bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensitive and Rapid determination of Trientine and N1-Acetyl Trientine in Human Plasma by LC-MS/MS for bioequivalence study
Authors: Nair Sheeba , Dasandi Bhavesh , Parmar Dharmesh , Shivprakash , , Karia Denish
Published: September 2024

A simple and robust method for simultaneous determination of Trientine and N1-Acetyl Trientine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated. The analyte and internal standard were extracted from 200 μL plasma by liquid phase extraction. Chromatographic analysis was carried out on column Xtimate, C18 (4.6 x 50 mm) 5 μm with a flow rate of 1 mL/min, at 40˚C temperature. An isocratic elution method was applied using (A) Acetonitrile - 80% and (B) 10mM Ammonium Acetate in water - 20%.  Detection and quantitation was done by multiple reactions monitoring in positive ionization with Q3 LCMS-8050, Shimadzu. Mass parameters 1035.45/1030.55 m/z and 855.15/859.50 m/z on a triple quadrupole mass spectrometer were chosen for analysis of Trientine and N1-Acetyl Trientine. Linearity was established in human plasma covering the concentration range 10.009 ng/mL to 1000.571 ng/mL for Trientine and 10.009 ng/mL to 1000.628 ng/mL for N1-Acetyl Trientine. Correlation coefficient was consistently greater than 0.99 for Trientine and N1-Acetyl Trientine using Trientine-D4 and N1-Acetyl Trientine Trihydrochloride D4 as internal standards. Different parameters such as linearity, range, precision, accuracy, ruggedness and robustness, limit of detection (LOD) and limit of quantification (LOQ) were used for a full validation of this method. The results were found to be acceptable as per the guidelines of International Conference on Harmonization (ICH), CDER, EMA1,2,3,4,5. The developed and validated method was successfully applied to estimate Trientine and N1-Acetyl Trientine in a bioequivalence study in healthy human volunteers. Assay reproducibility was checked by reanalysis of samples near the Cmax and the elimination phase in the pharmacokinetic profile of the drug.
Keywords: Trientine and N1-Acetyl Trientine, LC-MS/MS, Validation, ICH.
Quantitative Structure Activity Relationships in Computer Aided Drug Design: A Review
Authors: Niranjan Divya , Gill Simran , Shrivastava Deepali , Jain Aakash , Agrawal Om Prakash
Published: September 2024

The process of processing a drug and reaching to the market consists of various steps. In the early times of Drug Discovery, researchers faced with little or no Structure Activity Relationships information regarding any chemical moiety. Computer Aided Drug Designing (CADD) is a discipline allowing various aspects of research to merge together and stimulate each other. CADD acts as a tunnel in Drug Discovery and accelerates finding new lead compounds. The theoretical basis of CADD involves quantum mechanics and molecular modelling studies like Structure-based design, Ligand-based design, database searching and binding affinity. QSAR is structural descriptors of chemical compound to its biological activity. It is very important to find out relationships between molecular structure and useful properties and so Drug Discovery and Development get more complex. But automation of chemical synthesis and pharmacological screening provides a vast amount of experimental data.
Keywords: QSAR, Drug Design, CADD, Descriptor.
Aeromycological approach of some fungal diseases on Tomato Crop (Lycopersicon esculentum Mill.) at Nashik, India 422007
Authors: Kapadi M.R. , Patel S.I.
Published: September 2024

Tomato (Lycopersicon esculentum Mill.) family Solanaceae is the most popular and widely grown vegetable crop in India and throughout the world and having highly nutritious and medicinal value. Tomato crop and yield suffers from number of fungal diseases and shows correlation ship with airborne fungal spores and meteorological parameters; like mean temperature, relative humidity and average rainfall. The present investigation is done over Tomato field by using Rotorod air sampler (Tilak 1987) during Kharif season in Nashik, India. Weather conditions play an important role in seasonal development of many plant diseases. The present studies reveals the high concentration of air born pathogenic fungal spores were responsible in diseases incidence in Tomato crop. Some of them are Early blight (Alternaria solani), Late blight (Phytophthora species), Fusarium stem rot (Fusarium species) and showed more or less severity during the entire period of investigations.
Keywords: Tomato, Rotorod sampler, Kharif season, Nashik.
Chemotherapeutic drugs, modes of delivery and efficacy
Authors: Xu Shu
Published: September 2024

See PDF
Antioxidant Activities and GCMS Analysis of Anacardium occidentale L. Fruits
Authors: Baskar M , Kiranmathyi B , Sivaraj C , Saraswathi K , Arumugam P
Published: September 2024

Anacardium occidentale belongs to the family Anacardiaceae is a tropical evergreen tree with spreading branches which are supported by aerial roots that go down into the soil to form the 'props'. The milky latex is applied externally for treating pains in rheumatism and in lumbago. The infusion of the bark is used against dysentery, diarrhoea and diabetes. The study aims to evaluate the antioxidant activities and GC-MS analysis of ethanol and aqueous fruit extracts of Anacardium occidentale. The antioxidant assays such as DPPH˙ radical, Superoxide (O2.‑) radical, ABTS●+ radical cation scavenging activities, phoshomolybdenum reduction and Fe3+ reduction activities were carried out for ethanol and aqueous fruit extracts. The maximum DPPH˙ radical scavenging activity for ethanol extract was 93.33±0.23 at 120 µg/mL concentration and the IC50 was 38.29 μg/mL concentration. The maximum superoxide (O2.‑) radical scavenging activity was 75±0.25 at 120 µg/mL concentration and the IC50 was 38.52 μg/mL concentration for ethanol extract. The maximum ABTS●+ radical cation scavenging activity for ethanol extract was 82.57±0.37 at 30 µg/mL concentration and the IC50 was 11.13 μg/mL concentration. The maximum phosphomolybdenum reduction was 92.94±0.19 at 120 µg/mL concentration and the RC50 was 17.75 μg/mL concentration for ethanol extract. The maximum Fe3+ reduction for ethanol extract was 75.99±0.31 at 120 µg/mL concentration and the RC50 was 40.48 μg/mL concentration. GC-MS analysis showed different ester derivative compounds present in the ethanol fruit extract of Anacardium occidentale exhibiting antioxidant, anti-inflammatory, antimicrobial activities.
Keywords: Anacardium occidentale, DPPH˙ radical, Superoxide (O2.‑) radical, ABTS●+ radical cation GC-MS analysis.
Osteoarthritis: pathophysiology and current treatment modalities
Authors: Bhagat Roshan , Saudagar Ravindranath
Published: September 2024

Osteoarthritis (OA) is accepted as a major public health problem. It is one of the major causes of impaired function that reduces quality of life (QOL) worldwide. OA is a very common disorder affecting the joint cartilage. As there is no cure for OA, treatments currently focus on management of symptoms. Pain relief, improved joint function, and joint stability are the main goals of therapy. The muscle weakness and muscle atrophy contribute to the disease process. So, rehabilitation and physiotherapy were often prescribed with the intention to alleviate pain and increase mobility. However, as exercise has to be performed on a regular basis in order to counteract muscle atrophy, continuous exercise programs is recommended in people with degenerative joint disease. Therapeutic exercise regimes either focus on muscle strengthening and stretching exercises or on aerobic activity which can be land or water based. This article presents on overview of the current knowledge on OA and focuses on biomechanics, etiology, diagnosis and treatment strategies, conservative treatment including the physical therapy management are discussed. This information should assist health care practioners who treat patients with this disorder.
Keywords: OA; Strengthening exercises; Stretching exercises; Pain severity; Hamstrings / quadriceps ratio, knee osteoarthritis, cartilage degeneration, non-inflammatory arthritis, intra-articularinjections, corticosteroids
An integrative review of Cisplatin: the first metal Anti-Tumor drug.
Authors: Jadon Arvind Singh , Bhadauriya Poonam , Sharma Manoj
Published: September 2024

Cisplatin and other platinum derivatives like carboplatin and oxaliplatin are widely used chemotherapeutic agents used in the treatment of solid tumors including head and neck, ovarian and testicular germ cell tumors. Cisplatin is also used successfully in the treatment of paediatric malignancies, such as medulloblastoma and osteogenic sarcoma. In most recent treatment schedules, the drug is used in combination with other cytotoxic agents such as otoposide, doxorubicine, paclitaxel, 5-fluorouracil, gemcitabine, vinblastine, bleomycin and others. It is one of on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in health system. This comprehensive review highlights the physicochemical properties of cisplatin and related platinum based drugs, uses of platinum, either alone or in combination with other drugs for the treatment of various human cancers and also discuss about various Potential protective strategies against cisplatin-induced cytotoxicities. A special attention is given to it’s molecular mechanisms of action, historical background, undesirable side effects & future prospective.
Keywords: Cisplatin, cytotoxicity, cis-diamminedichloroplatinum.
Phenotypic characterization and identification of bacterial isolates from smoked fish
Authors: Reyes Alvin T , Reyes Alfred T , Bermudez Jay L , Atayde Jimbo D , Aguilar John Paul T , Estes Jojie G , Baltazar Luigi S , Calapardo Michael E , Vallada Roval L
Published: September 2024

This study aimed to phenotypically characterize and identify bacterial isolates from smoked fish. From the seven morphologically different bacterial colonies, four of them were identified using selective/differential media. The two isolates belong to genus Pseudomonas while the remaining two were confirmed under genus Staphylococcus. Results of gram-staining, motility and selected biochemical and physiological tests supported the identity of the four isolates. Pseudomonas isolates were found resistant to 30 µg tetracycline while Staphylococcus isolates were intermediate to susceptible on the said antibiotics. Unhygienic preparation of the smoked fish could be the possible reason for the product contamination.
Keywords: Smoked fish, phenotypic characterization, biochemical test, physiological test, antibiotic susceptibility
Two-tailed fancy goldfish challenged with Bacteroides spp. isolated from shubunkin goldfish
Authors: Reyes Alvin T
Published: September 2024

This study aimed to isolate, morpho-biochemically characterize and identify the most common bacterium in diseased shubunkin goldfish, and challenge the two-tailed fancy goldfish using the identified bacterium.  With the aid of Bergey’s Manual of Determinative Bacteriology, the bacterium was identified as Bacteroides spp. The bacterium was characterized as follows: Gram-negative, coccobacillus, facultative anaerobe, hemolytic, glucose and sucrose fermentative but not lactose and xylose, negative to catalase, Methyl red, Voges-Proskauer and hydrogen sulphide production tests, and positive to Simmon’s citrate utilization, liquefaction of gelatin, nitrate reduction, urea hydrolysis and indole production.  Two-tailed goldfish challenged with Bacteroides spp. showed clinical signs such as gasping for air, irritability, sloughing of scale, lesion and watery internal organs.
Keywords: Shubunkin goldfish, two-tailed goldfish, biochemical tests, Bacteroides
Histopathological changes in the rat liver and kidney with references to nicotine toxicity
Authors: Singh Romsha , Singh Kalpana
Published: September 2024

Nicotine, the principal alkaloid in tobacco, induces a cellular damage on heart and cardiomyocyte culture. The present study was undertaken to investigate the effects of green tea and guduchi extracts on nicotine-induced alterations in some organs of adult male mice (liver and kidney) by using histopathological studies. A total of 36 mice were divided into six groups For histopathological studies. Liver and kidney were excised from both control and experimental mice sacrificed on 60th day. Statistical analysis was performed for comparison between the groups by using Dunnett’s test. There was decreased inflammatory infiltration and intracellular edema in histology of renal tissue from green tea and guduchi extracts treated mice reflected a reduction in nicotine-induced renal damage. The histopathological examination of liver clearly revealed that the Hepatic Cells, Intact nucleus, and Central Vein, portal triad were almost normal in other groups in contrast to group which received inducer but with mild Kupffer cell hyperplasia.The results of present work suggested that green tea and guduchi extracts has a promising prophylactic effect against nicotine-induced oxidative damage of liver and kidney.
Keywords: Green tea, Guduchi extracts, Histopathology, Liver, Kidney, Toxicity, Mice.
Colorimetric method for determination of corticosteroids by UV Visible Spectroscopy and its application to Ayurvedic formulations
Authors: Salomi P. , Sucharitha B. , Swathi T. , Hemalatha P. , Ravivarma K. , Venkata Ramana A. , Ravindra Reddy K.
Published: September 2024

Usage of herbomineral preparations increased drastically these days. Some of the Ayurvedic formulations are been adulterated with steroids. Usage of such formulations can be injurious to health. Hence an attempt has been made to identify and determine steroids in both Ayurvedic and pharmaceutical formulations. In the present study a simple, sensitive and economical visible spectroscopic method has been used which involves the oxidation of corticosteroids by iron(III) and subsequent complexation of iron(II) with potassium  hexacyanoferrate (III), forming bluish green colored complex having the maximum absorbance at 780 nm. The method has been applied for the determination of corticosteroids in Ayurvedic formulations. The method has been statistically validated in which the  Standard deviation ranging  from  0.0008 to 0.0135,Relative standard deviation from 0.08% to 1.35% and Standard error was varying from 0.0018 to 0.0060 for selected Ayurvedic formulations. The studies have shown that the method is fast, reproducible and accurate and can be used in the analysis of marketed formulations. The processed samples were stable up to 2 hours minimizing the error in terms of fluctuating absorbance values.
Role of naturally isolated pear starch on the bioavailability of famotidine
Authors: Kushwaha Anjali , Singh Pratap Manjul
Published: September 2024

Purpose- The bioavailability of any drug in the formulation is affected by various excipients presents in it.  In case of tablets the role of binders is very important for dissolution of dosage form as well as bioavailability of drug. Thus in following study an attempt is made to improve the dissolution of drug by using pear starch as binding agents. The starch was extracted from the Pear fruits and used as a binder in different concentrations, in famotidine tablets and then evaluate them.
 Methods-The tablets were formulated by wet granulation method by using 2% w/v, 4% w/v, 6% w/v and 8% w/v of pear starch as binding agent. Then formulated famotidine tablets were further evaluated for various parameters i.e. weight variation, hardness, friability, disintegration time and in-vitro drug release and in vivo study.
Results-The hardness and disintegration time of the tablets was found to be increased with increase in starch concentration. Tablets with highest binder concentration showed maximum hardness 6.5 kg) and disintegration time (10 min) and minimum friability (0.48%). After one hour tablets with 4% w/v starch showed maximum drug release (80.69%). The optimized formulation then go for in vivo study, shows better bioavailability as compares to marketed one. Hence isolated starch shows increase in the dissolution and bioavailability, when used as binder in tablet formulations.
Conclusions- The results from various evaluations show that pear starch has significant binding characteristics. Hence it can be used as tablet binder in pharmaceutical formulations for future aspects.
Keywords: Starch, binder, tablets, in-vitro dissolution, famotidine
OVERCOMING PAIN: AN EXPLORATION OF ANALGESIA IN IBN SINA’S AL-QANOON FIL TIBB
Authors: Nikhat Sadia , Shamsi Yasmeen , Fazil Mohd.
Published: September 2024

Ibn Sina (980-1037 AD), latinized as Avicenna was a Persian scholar, physician, scientist and medical writer whose works had a lasting influence on medical education for more than seven centuries. He is known to have authored more than 400 books, of which many could not be preserved. His most famous treatise is Al-Qanoon Fil Tibb (The Law in Medicine) which is a medical encyclopedia in five volumes. Pain is described in the first volume, alongwith its clinical features, causes and management. Pain is mentioned by the name of waja‘ (hurt) and described as a feeling contrary to the body. He described fifteen types of pain based on their causative factors and differentiated them on their clinical presentation, for instance, waja‘-i-Mukassir (breaking pain), waja‘-i-I‘iyāiī (fatigue pain), waja‘-i-Ḍarabānī (throbbing pain) etc. For their management, he has prescribed different classes of drugs which act through diverse routes. Mukhaddir (narcotic or anaesthetic) are used for symptom relief, murkhī (relaxant) are advised when there is pent-up matter to help in its resolution, muḥallil-i-waram (anti-inflammatory) drugs are prescribed for inflammatory pains and mus’hil (purgative) drugs are prescribed if the morbid matter has to be excreted through intestines. In addition, an account of other effective regiems such as cupping, massage, music therapy and use of exhilarants is also described in Al-Qanoon.
ROLE OF METALS IN PREPARATION OF NANOFLUIDS
Authors: Chaudhari Pallavi M , Nagare Ashwini S.
Published: September 2024

Nanofluids are dispersion of nanoparticles in base fluids, it’s a new challenge for thermal sciences given by nanotechnology Due to their excellent features, nanofluids find wide applications in enhancing heat transfer.These shows large increase of thermal conductivity in comparison with their base fluids.The particles used are generallymetal or metal oxide which increases thermal conductivity & convection coefficient. Metallic nanofluids are prepared by dispersing nanoparticle made from metals such as aluminum, silicon ,iron, silver, gold, , titanium , copper, nickel etc. and nonmetallic nanofluids are prepare by dispersing nanoparticles of nonmetals i.e. metal oxides, various allotropes of carbon for example; Graphene, CNTetc. Synthesis and stability of nanofluids are the two very primary parameters to study nanofluids
A review on efficacy and tolerability of tea tree oil for acne
Authors: Ahmad Shamshad , Afsana , , Popli Harvinder
Published: September 2024

Acne is common problem acquired generally after puberty. It ranges from mild to moderate: papules, pustules, nodules to severe cyst. Various natural therapy can be employed for treatment of acne including Tea tree oil (TTO). Tea tree oil has wide spectrum anti-microbial agent showing in treatment of acne. Usually it is utilized in various topical preparations. It contains more than 80-90% monoterpenes namely terpinen-4-ol, -cymene, α-terpinene, limonene 1,8-cineol, α-terpineol, terpinolene,  1,8-cineol, sabinene and  α-pinene,  The European cosmetic Association recommended not more than 1% use of tea tree oil in cosmetic preparations. In this review, we listed various efficacy and tolerability studies along with challenges in application of tea tree oil in cosmetics and dermatological preparations. TTO is a moderate sensitizer and upon oxidation it increases in its allergenic potency. This is a comprehensive review of using Tea tree oil against various microbial species. Various studies revealed the use of TTO as anti-bacterial, anti-fungal, anti- oxidant agent. TTO is effective treatment option that can further be utilized in preparation of novel formulations like liposomes, ethosomes along with combination with other anti-microbial and anti-oxidant agents.
Keywords: Acne, Tea-tree oil, Application, Antioxidant, Nano particles.
Safety Study of a Non-pharmacopial compound Unani formulation
Authors: Ali Mokarram , Khan Naeem A. , Ahmad Ghufran
Published: September 2024

Herbal drugs are in use since antiquity with an assumption that they are almost devoid of side effects. But many reports published in recent years suggest that they are liable to produce a number of side effects. Keeping it in view WHO has proposed a guideline of safety study herbal drugs and food products. It includes the determination of Aflatoxin, heavy metals, pesticide residue and Microbial load. A non pharmacopoeal Unani formulation containing Tukhm-e-konch, (Mucuna pruriens), Khulanjan, (Alpinia galangal), Salabmishri, (Orchis latifolia), is commonly used for sex improving effect. This combination has also been proved effective in experimental studies but the safety study as per WHO guidelines has not been conducted. Therefore the present study was carried out to determine the presence or absence of the toxic components in the test drug.The protocol suggested by WHO was used during the study. The combination was found to be safe as all the component was found within the permissible limits.
Amyotrophic Lateral Sclerosis: An Overview
Authors: Saudagar Ravindranath , Garge Lajri
Published: September 2024

Amyotrophic Lateral Sclerosis is an adult-onset neurodegenerative disease that causes paralysis. Presently it is incurable and rapidly progressive with a survival of 4-5 years from onset. It is degeneration of upper and lower motor neurons which results in weakness and wasting of muscles in arms, legs, trunk and bulbar region. There are two types sporadic and familial amyotrophic lateral sclerosis. The age of onset of people with familial is widely reported as being about 10 years younger than for those with apparently sporadic amyotrophic lateral sclerosis. Epidemiological studies show a worldwide incidence of 2-3 per year per 100-000 population over age of 15 years. About 10% of individuals have a family history of amyotrophic lateral sclerosis. The cause is unknown. Genes linked to diseases have been identified including one (C9ORF72) that seems to be particulary important. Researchers are studying several causes of ALS like gene mutation, chemical imbalance, disorganized immune response and protein mishandling. Riluzole and Radicava were approved for the treatment by the Food and Drug administration. The diagnosis of ALS is devastating for patient and family members. People with ALS should be delivered with multidisciplinary team. The current hope is that stem cells of neural or extraneural origin might be modified in vitro to neurons that may migrate to the sites of motor neuron loss. The quality of life is important not just the duration of survival.
Keywords: Amyotrophic Lateral Sclerosis, Motor neuron diseases, Sporadic, Familial, Pathogenesis.
Investigation of anti-inflammatory activity of ethanolic extract of Aconitum Napellus Linn against carrageenan induced paw edema in rats
Authors: Gupta Ruchi , Saxena Rajiv , Malviya Neelesh
Published: September 2024

The Indian herbal medicine is evaluated by comprehensive activity of research on herbal plant species and their therapeutic principles in the whole world. In traditional and modern medicine, the medicinal plants are used which have shown their potential in possessing potent bioactive compound. A large number of populations suffer due to various reasons from rheumatoid arthritis of unknown inflammation. The present work is to investigation of anti-inflammatory activity of herbal extracts of Aconitum Napellus Linn against carrageenan induced paw edema in rats. Aconitum Napellus Linn plant extracts used in traditional medicine was investigated for their anti-inflammatory potential against adjuvant carrageenan induced inflammation. Maceration method was used for preparing ethanolic extract. In adjuvant carrageenan induced inflammation, orally administered extracts (100 mg/kg), inhibited the acute as well as chronic inflammation. The ethanolic herbal extract of plant under investigation showed potent anti-inflammatory activity. The anti-inflammatory activity of the extracts was compared to reference drug, diclofenac (10 mg/kg).
Keywords: Anti-inflammatory, Paw edema, Aconitum napelluslinn, Maceration.
Microspheres for local drug delivery in bone joints
Authors: Poudyal Adarsh Pratik , Soundrapandian Chidambaram
Published: September 2024

Bone joints are the junctions between bones in the body which link the skeletal system into a functional whole. A joint may be the connecting point between two or more bones. Overtime, as people age or due to lifestyle or genetic factors, they may experience diseases and pains in the joints. Conventional treatment options for bone and joint diseases, pain and inflammation have a number of drawbacks that obstruct optimal treatment of the disease. Various other treatment methods and formulations have been investigated to remove these drawbacks. Microspheres are one of the most interesting and attractive approaches to eliminate these limitations. In recent years, prolonged release microspheres have been developed and explored as a viable method for delivery of drugs to the bones and joints. Local delivery of drugs to the affected bone or joint offers many advantages over traditional treatment methods including- better therapeutic response, lesser required dose of drug, lesser chances of wastage of drug, better absorption of drug in the diseased site, lesser chances of side effects etc. The objective of this review is to explore the field of drug delivery to bone joints, various methods of development of drug-loaded microspheres, factors that influence the release of drug from the microspheres as well as the types of hurdles faced in their preparation.
Keywords: bone and joint diseases, drug delivery, microspheres, local drug delivery,
Anti-inflammatory Natural Compounds from Herbal and Marine Origin
Authors: Saudagar Ravindranath B. , Saokar Shivani
Published: September 2024

Inflammation is pathologic condition that includes variety of diseases throughout the world. Natural products have shown their effectiveness consistently in medicinal and cosmetic field. According to World Health Organization (WHO) still about 80% of the world population rely mainly on plant-based drugs. In Ayurveda, Siddha, and Unani, utilizing a large number of medicinal plants were used for the treatment of human diseases. Herbal natural sources have ability to synthesize a wide range of phytochemical compounds which shows anti-inflammatory activity. Secondary metabolites such as alkaloids, flavonoids, saponins, coumarins, terpenoids and essential oils have clinically and experimentally shown anti-inflammory properties over the years. With the emerging developments in natural products, the marine environment has been shown to be the source of a great diversity of chemical structures with promising biological activities. Marine organisms and microorganisms have provided a large proportion of the natural anti-inflammatory products over the years. Marine sources includes bioactive compounds from micro-organisms, such as algae, bacteria, cyanobacteria, fungi and small invertebrates, such as sponges, mollusks, tunicates, echinoderms and phytoplankton’s. Algal anti-inflammatory phytochemicals have the potential to be used as therapeutics or in the synthesis of structural analogs with profound anti-inflammatory activity with reduced side effects. This review describes anti-inflammatory activity of some secondary metabolites discovered from herbal and marine sources.
Key words: Anti-inflammatory, Phytochemical, secondary metabolites, Herbal, Marine
Pensar el cuidado desde la continuidad espacial. Aportes de la geografía y el urbanismo feminista
Authors: Guzmán Rodríguez Paola Berenice
Published: September 2024

El presente artículo toma como ejes rectores algunos de los aportes realizados desde la geografía y el urbanismo feminista para explorar cómo en la vida cotidiana el trabajo de cuidado desafía la dicotomía espacial público-privado. Mediante la recopilación de datos estadísticos se muestra que la realización del trabajo de cuidados impacta de manera significativa la forma en la que las personas hacen uso del tiempo y del espacio. A modo de reflexión se señala la urgencia por subvertir el orden establecido y dar lugar a otras configuraciones espaciotemporales que permitan el sostenimiento de la vida desde la dignidad, la diversidad, la justicia y la igualdad de derechos.
Las huellas del camino
Authors: D’Alton Kilby Cristina
Published: September 2024

Antes de que se disipen nuestras huellas en el mar, podemos rescatar algunos retazos del sentido que las imprimió allí, en busca de un camino hacia el futuro. No podemos volver sobre ellas; sí podemos aprender de ellas para colocar nuestras huellas en lo que para nosotros ahora es el futuro. El aprendizaje es un viaje; la vida es aprendizaje.
Propensión marginal al consumo y ahorro desde una perspectiva microeconómica
Authors: Muñoz - Medrano Janira Francisca , Brenes González Humberto Antonio
Published: September 2024

El presente artículo denominado “Propensión marginal al consumo y ahorro desde una perspectiva microeconómica”, tuvo como objetivo estimar la propensión marginal al consumo y al ahorro, por parte de los trabajadores de la empresa JMC, durante el período comprendido de 2021 – 2022, a partir del ingreso y el consumo de los mismos.
La investigación tuvo un enfoque cuantitativo, de tipo no experimental, correlacional y de corte transversal. La metodología utilizada para estimar la propensión marginal al consumo fue bajo un modelo de regresión lineal, siendo el Consumo (C) la variable dependiente y el Ingreso (I) la variable independiente.
Los coeficientes de la constante y de la pendiente (la cual representa la propensión marginal al consumo) fueron estimados de forma manual mediante el uso del método de los determinantes de Cramer. A su vez, se procedió a realizar las estimaciones de los coeficientes mencionados, mediante el lenguaje de programación con enfoque estadístico R-Studio y el programa de Office Microsoft Excel. La propensión marginal al ahorro, se obtuvo mediante la diferencia de uno menos el coeficiente estimado de la propensión marginal al consumo.
Los resultados mostraron una fuerte correlación entre las variables en estudio (97.32%), así como también, un alto grado de explicación que tienen los ingresos sobre el nivel de consumo (94.71%), además, se estimó que la propensión marginal al consumo de los trabajadores de la empresa JMC que, fue de (0.8427), siendo la del ahorro de (0.1573).
Foreign trade of the Slovak Republic with selected agrarian commodities of animal origin
Authors: Šimo Dušan
Published: September 2024

Paper points at research of import and export of beef, pork, poultry, cows milk, cheese curds and chicken eggs. Agriculture on the market of the Slovak Republic overcomes imbalanced due to extra labor deployment of enterprise-level management and other staff. Agrarian market was significantly affected by the world financial crisis, which was reflected in our conditions by the growth of gross domestic product, increased unemployment, reduced consumer purchasing power and declined demand for the key agri-food commoditiess. Similar imbalances are also in the agrarian markets of the other EU accession countries and third countries. Beside these factors in a significant proportion of the agrarian market volatility can be attributed to the impact of weather conditions in Europe and the world, mainly due to floods, fires, but also fluctuations in oil and other energy sources. Those and other negative factors affect the results of the agri-business management subjects. Increasing costs of production critical industries plant and animal production enterprises are the result of low competitiveness of domestic producers in comparison with the developed EU agrarian countries
Possibilities of using of the venture capital as an innovative instrument in conditions of the Slovak republic in the competence of the National Agency for Development Small and Medium Enterprises
Authors: Szabóová Mária
Published: September 2024

The contribution describes the venture capital as an innovative instrument used in the Slovak republic. Basic characteristic of venture capital presents its advantages and disadvantages, as well as describes the existing venture capital funds in the Slovak republic and the venture capital programmes are given in the first part. Hereby, the contribution describes monitoring of development of venture capital investments in the Slovak republic in the competence of the National Agency for Development Small and Medium Enterprises. Finally, the paper presents possibilities as we can improve availability of the venture capital in our conditions
Budżet zadaniowy na przykładzie Regionalnej Dyrekcji Ochrony Środowiska w Szczecinie
Authors: Kiełsznia Michał , Łagodzki Przemysław
Published: September 2024

Wdrożenie budżetu zadaniowego ma przełomowe znaczenie dla sektora finansów publicznych. Stanowi on efektywne narzędzie zarządzania ukierunkowane na osiąganie zaplanowanych celów. Idea wprowadzenia i realizowania zasadniczych celów w układzie budżetu zadaniowego pozwala w sposób kompleksowy dokonywać. monitoringu prowadzonych działań. Tak pod względem ich celowości, przejrzystości, gospodarności, jak i efektywności. Ponadto umożliwia ona dokonywanie porównań oraz analiz odchyleń stanów oczekiwanych, w zakresie realizowanych zadań, od przyjętych założeń. Wszystkie realizowane w ramach budżetu zadaniowego zadania i programy mogą. być także poddawane permanentnej ocenie – tak w trakcie ich trwania, jak i po ich zakończeniu.
Zadłużenie gospodarstw domowych w UE-15 i nowych państwach członkowskich UE w latach 2001-2010
Authors: Kozak Sylwester
Published: September 2024

Okres pierwszej dekady lat 2000. w krajach Unii Europejskiej charakteryzował się silnym wzrostem zadłużenia gospodarstw domowych. Na koniec dekady zadłużenie gospodarstw domowych w krajach UE-15 osiągnąło poziom 60% PKB. W nowych państwach członkowskich UE (NMS) poziom ten był początkowo znacznie niższy, ale w przyspieszonym tempie zbliżał się do średniej w UE. Celem artykułu jest analiza zmian wielkości i struktury zadłużenia gospodarstw domowych w krajach UE-15 i NMS w latach 2001-2010. W badaniach wykorzystano dane z Eurostatu, EBC i OECD. Wyniki analizy wskazują, że w pierwszych latach dekady najsilniej zadłużone były gospodarstwa domowe w krajach UE-15, jednak po rozszerzeniu UE w krajach NMS zanotowano większe roczne tempo wzrostu zadłużenia. światowy kryzys finansowy przyczynią się do okresowego ograniczenia tempa wzrostu zadłużania się gospodarstw domowych w obu obszarach UE, ale zmiana ta była tylko okresowa. W 2010 r. proces zadłużania się gospodarstw domowych powrócić do trendu wzrostowego w całej UE. W kilku krajów UE-15 zadłużenie gospodarstw domowych znacznie przekroczyło wartość ich dochodów do dyspozycji. Kredyty mieszkaniowe dominowały w strukturze zadłużenia gospodarstw domowych w całej UE
Agencja Nieruchomości Rolnych planowanie finansowe dziś i wyzwania na przyszłość
Authors: Postuła Marta
Published: September 2024

Rolnictwo od początku okresu osadnictwa odgrywało ważną rolę w życiu ludzi. Państwo finansuje związane z prowadzona polityka rolną z środków budżetu państwa i źródeł zasilających bezpośrednio realizujące je inne jednostki sektora finansów publicznych. Redystrybucja bowiem odbywa się w znacznej mierze za pośrednictwem utworzonych specjalnie w tym celu jednostek sektora finansów publicznych takich jak: Agencja Restrukturyzacji i Modernizacji Rolnictwa, Agencja Rynku Rolnego, Agencja Nieruchomości Rolnych. W związku z powyższym polityka rolna oraz rybacka jest również jedna ze zdefiniowanych 22 odrębnych funkcji państwa wydzielonych w ramach metodyki budżetu zadaniowego i planowania wieloletniego. nad bezpieczeństwem rynku zywnościowego. Referat poświecony jest omówieniu zagadnień zwiazanym z Agencja Nieruchomości Rolnych pod kontem zalet jakie dla jej gospodarki finansowej mogą wypływać z wprowadzenia przygotowania i realizacji jej planu finansowego w układzie zadaniowym oraz dotychczasowych doświadczeń w tym zakresie. W przedkładany referacie zaprezentowane zostały dotychczasowe doswiadczenia Agencji Nieruchomości Rolnych w planowaniu zadaniowym, ze szczególnym zwróceniem uwagi na sformułowane cele oraz mierniki wskazujące na stopień ich realizacji
Uwarunkowania prawne i organizacyjne dotyczące wdrażania budżetu zadaniowego w sektorze finansów publicznych
Authors: Walenia Alina
Published: September 2024

Stosownie do przepisów ustawy o finansach publicznych kontrolę zarządczą w jednostkach sektora finansów publicznych stanowi ogół działań podejmowanych w jednostce dla zapewnienia realizacji celów i zadań w sposób zgodny z prawem, efektywny, oszczędny i terminowy. Standardy kontroli zarzadczej dla sektora finansów publicznych, zgodne z międzynarodowymi standardami (INTOSAI) określone zostały w formie komunikatu i ogłoszone w Dzienniku Urzędowym przez Ministra Finansów. Zapewnienie funkcjonowania adekwatnej, skutecznej i efektywnej kontroli zarządczej należy do obowiązków ministra w kierowanych przez niego działach administracji rządowej, wójta (burmistrza, prezydenta miasta, przewodniczącego zarządu jednostki samorządu terytorialnego) oraz kierownika jednostki sektora finansów publicznych. Niewypełnienie lub niewłaściwa realizacja obowiązków w zakresie kontroli zarządczej objęta jest odpowiedzialnością za naruszenie dyscypliny finansów publicznych na podstawie znowelizowanej ustawy z dnia 17 grudnia 2004 r. o odpowiedzialności za naruszenie dyscypliny finansów publicznych.
On class of fractional impulsive hybrid integro-differential equation
Authors: Hannabou Mohamed , Bouaouid Mohamed , Hilal Khalid
Published: September 2024

In this work, a class of a impulsive hybrid fractional integro-differential
equation with hybrid boundary conditions is studied by the generalization of
Dhage?s fixed point theorem by three operators. This study ends with on
example illustrating the theoretical findings.
Initialization of the difference of convex functions optimization algorithm for nonconvex quadratic problems
Authors: Achour Saadi , Rahmoune Abdelaziz , Ouchenane Djamel , Alharbi Asma , Boulaaras Salah
Published: September 2024

The Difference of Convex functions Algorithm (DCA) is used to solve nonconvex
optimization problems over a certain convex set, specifically quadratic
programming ones, generally by finding approximate solutions. DCA efficiency
depends on two basic parameters that directly affect the speed of its
convergence towards the optimal solution. The first parameter is the
selected decomposition and the second is the assigned initial point. The aim
of this study was to create a new algorithm that allows overcoming the need
for a pre-selected initial estimate of the DCA. To achieve this aim, we
performed an experimental study with 107 test problems using an
implementation framework with MATLAB. Assessment was based on key
performance indicators: (a) the time required to reach the initial point and
solution and (b) the number of iterations. We selected three initial points,
the first (xlin 0) is the minimum of the linear part of the nonconvex
quadratic problem (NCQP), the second (xcvx 0) is the approximate global
minimum of the convex part, and the third (xcve 0) is the approximate
global minimum of the concave part. We compared between the minimuma
computed by DCA for each of the three initial estimates. The results
demonstrated clear advantage of the DCA algorithm with (xlin 0). Based on
this outcome, we constructed a novel algorithm called Initialized DCA (IDCA)
that allows implementation of the DCA with the best initial estimate without
the requirement for a pre-determined initial point.
An inverse result for Wang’s theorem on extremal trees
Authors: Damnjanovic Ivan , Randjelovic Zarko
Published: September 2024

It was recently noted by Damnjanovi?c et al. [MATCH Commun. Math. Comput.
Chem. 90 (2023), 197?202] that the problem of finding a tree which minimises
or maximises the Sombor index among all the trees with a given degree
sequence fits within the framework of results by Hua Wang from [Cent. Eur.
J. Math. 12 (2014), 1656?1663]. Here, we extend these results by providing
an inverse for the aforementioned theorem by Wang. In other words, for any
fixed symmetric function f satisfying a monotonicity condition that f (x, a)
+ f (y, b) > f (y, a) + f (x, b) for any x > y and a > b, we characterise
precisely the set of all the trees minimising or maximising the sum f (deg
x, deg y) over all the adjacent pairs of vertices x and y, among the trees
with a given degree sequence.
A bivariate probability generator for the odd generalized exponential model: Mathematical structure and data fitting
Authors: El-Morshedy Mahmoud , Eliwa Mohamed
Published: September 2024

The generalized exponential (GE) distribution is the well-established
generalization of the exponential distribution in statistical literature.
Tahir et al. (2015) proposed a flexible probability generator called the odd
generalized exponential-G (OGE-G) family of distributions. In this article,
we propose a bivariate extension of the OGE-G class, in the so-called the
bivariate odd generalized exponential-G (BOGE-G) family of distributions,
whose marginal distributions are OGE-G families. Important mathematical and
statistical properties of the BOGE-G family including joint density function
with its marginals, Marshall-Olkin copula, product moments, covariance,
conditional densities, median correlation coefficient, joint reliability
function, joint hazard rate function with its marginal functions, marginal
asymptotic, and distributions for both max(X1,X2) and min(X1,X2), are
derived. After the general class is introduced, a sub-model is discussed in
detail. The maximum likelihood approach is utilized for estimating the
bivariate family parameters. A simulation study is carried out to assess the
performance of the sub-model parameters. A real-life data set is analyzed to
illustrate the flexibility of the proposed bivariate class.
Further results on I−deferred statistical convergence
Authors: Choudhury Chiranjib , Debnath Shyamal , Esi Ayhan
Published: September 2024

For a non-empty set X, an ideal I represents a family of subsets of X that
is closed under taking finite unions and subsets of its elements.
Considering X = N, in the present study, we set forth with the new notion of
I?deferred statistical limit point, I?deferred statistical cluster point and
study various properties of the newly introduced notion. For a real valued
sequence x = (xn), we prove that every I?deferred statistical limit point is
an I?deferred statistical cluster point. Moreover, the collection of all
I?deferred statistical cluster points of x is a closed subset of R. We also
introduce the notion of I?deferred statistical limit superior and inferior
for real valued sequences and prove several interesting properties. In the
end, we establish a necessary and sufficient condition under which a
I?deferred statistically bounded real valued sequence is I?deferred
statistically convergent.
Greville type {1,2,3}-generalized inverses for rectangular matrices
Authors: Wu Cang , Chen Jianlong
Published: September 2024

For any complex matrices A and W, m? n and n ?m, respectively, it is proved
that there exists a complex matrix X such that AXA = A, XAX = X, (AX)* = AX
and XA(WA)k = (WA)k, where k is the index of WA. When A is square andW is
the identity matrix, such an X reduces to Greville?s spectral {1, 2,
3}-inverse of A. Various expressions of such generalized inverses are
established.
Pseudo-Ricci-Yamabe solitons on real hypersurfaces in the complex projective space
Authors: Suh Young , Woo Changhwa
Published: September 2024

In this paper, we give a complete classification of Hopf pseudo-Ricci-Yamabe
solitons on real hypersurfaces in the complex projective spaceCPn. As its
applications, first we give a complete classification of gradient
pseudo-Ricci-Yamabe solitons on real hypersurfaces with isometric Reeb flow
in the complex projective space CPn. Next we prove that a contact real
hypersurface in CPn which admits the gradient pseudo-Ricci-Yamabe soliton is
pseudo-Einstein.
Almost automorphic colombeau generalized ultradistributions and linear ordinary differential systems
Authors: Ouikene Fethia
Published: September 2024

The aim of this work is to introduce and to study the concept of almost
automorphy in the setting of generalized ultradistributions. Such
generalized ultradistributions contain their analogue of almost automorphic
ultraditributions and generalized functions. A result on the existence of
almost automorphic ultradistributional solutions of a linear ordinary
differential systems is given.
Lie higher derivations on triangular algebras without assuming unity
Authors: Liang Xinfeng , Ren Dandan
Published: September 2024

In this paper, we focus on the structure of Lie higher derivations on
triangular algebras T without assuming unity. We prove that Lie higher
derivation on every triangular algebra can be decomposed into a sum of a
higher derivation, an extreme Lie higher derivation, and a central mapping
vanishing on commutators [x, y]. As by-products, we use it on some typical
algebras: upper triangular matrix algebras over faithful algebras and
semiprime algebras, respectively.
The MPWG inverse of third-order F-square tensors based on the T-product
Authors: He Mengyu , Liu Xiaoji , Jin Hongwei
Published: September 2024

We define the T-MPWG inverse of third-order F-square tensors by using the
T-core EP decomposition of tensors via the T-product. Then, we present some
characterizations and properties of the T-MPWG inverse. Moreover, the
Cayley-Hamilton theorem of the third-order tensors is extended to T-MPWG
inverses. Examples are also given to illustrate these results.
Chronic diseases and self-assessment of health as predictors of unmet health needs of the elderly population in the Republic of Serbia: National health survey
Authors: Savic Nikola , Sovilj Sasa , Grbic Gordana , Arnaut Aleksandra , Jovanovic Verica , Kocic Sanja
Published: September 2024

Introduction/Aim. Unmet health needs are the difference between the health services considered necessary to solve a particular health problem and the health services that were actually received. Unmet health needs in the elderly population with chronic diseases can lead to deterioration of the health condition and complications. The aim of the study was to analyze the connection between the presence of chronic diseases and self-assessment of health with the unmet health needs of the elderly population. Methods. The study was part of the latest National Population Health Survey of the Republic of Serbia, conducted as a cross-sectional study on a representative stratified two-stage sample. Data from 3,450 respondents aged 65 and above were used for the purposes of the research. The research was conducted according to the European population health research methodology. Univariate and multi-variate logistic regression were used to assess predictors of unmet health needs. Results. Every third respondent with a chronic disease did not receive the necessary form of health care (36.3%). Dominant predictors of unmet health needs were self-assessment of health [odds ratio (OR) = 0.63; 95% confidence interval (CI) = 0.58?0.68] along with chronic diseases (OR = 2.29; 95% CI = 1.87? 2.81) and depression (OR = 2.12; 95% CI = 1.71?2.64). Respondents with a chronic health disorder were 2.2 times more likely to fail in the realization of the necessary health service compared to respondents who did not have long-term illnesses. Respondents who assess their own health as poor/very poor report unfulfilled health needs two times more often than respondents in good health. Conclusion. Unmet health needs in the elderly population are associated with self-reported health and the presence of chronic diseases. The results of such research can be the basis for a better organization of health care and the creation of health policies in order to improve the health of this population group.