bluuebunny/crossref_metadata_2025 huggingface dataset:
الإشارة في شعر المتنبي
Authors: الحمداني هادي
Published: March 2024

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الرواية الشعرية «لیلی و مجنون» في الادب الكردي
Authors: خزنه دار مروف
Published: March 2024

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نظرات في الأدب والاعلام قديما وحديثا
Authors: التكريتي منير بكر
Published: March 2024

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افنون التغلبي
Authors: البياتي عادل جاسم
Published: March 2024

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الألفاظ العربية المستعارة في لغة الهوسا
Authors: سلوم داود
Published: March 2024

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ظاهرة المفعول المطلق عند أبي تمام
Authors: حمودي هادي
Published: March 2024

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رمز المرأة في ادب ایام العرب
Authors: البياتي عادل جاسم
Published: March 2024

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المسكوكات المزيفة في العصر العباسي
Authors: حميد عبد العزيز
Published: March 2024

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تحول العقد بين الشريعة والقانون
Authors: العزاوي اجود علي
Published: March 2024

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لمحات من التاريخ السياسي للامبراطورية البارثية
Authors: الراوي احمد مالك
Published: March 2024

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مواضع المدن عند العرب في صدر الاسلام
Authors: العميد طاهر مظفر
Published: March 2024

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الستائر وانواعها في العصر العباسي
Authors: العلي زكية عمر
Published: March 2024

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المصدر الصريح والمؤول
Authors: السامرائي فاضل صالح
Published: March 2024

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معوقات مشاركة المراة في عملية التنمية
Authors: شكارة عادل عبد الحسين
Published: March 2024

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ابن الكوفي
Authors: محفوظ حسين علي
Published: March 2024

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المأساة عند اسكيلس
Authors: نادر كمال قاسم
Published: March 2024

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الامية والتخلف الاقتصادي
Authors: الراوي منصور
Published: March 2024

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تميم الداري
Authors: النجم وديعة طه
Published: March 2024

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How to Form the Human Brain
Authors: Grinde Bjørn
Published: March 2024

Modern societies are challenged by a range of problems; most, if not all, are aggravated by the way people behave. Our minds are shaped by the combined effect of genes and environment. The only practical option for modifying behavior is to adjust the impact of the environment. All communities try to mold their members; thus, the question is not _whether_ we should attempt to form the brains of future generations, but _how_ to optimize the outcome. In this review, I discuss desirable features, brain plasticity, and strategies for enhancing society by tweaking the mindset, and thus the behavioral propensities, of the population.
Optimization Of The Managemenr In Maluku Health Analysis Department
Authors: Natsir Ramdhani M
Published: March 2024

Introduction. Exam management is crucial in the implementation of evaluation in educational institutions. This is because the test implementation process is one of the determinants of the quality of an institution. This study aims to assess the optimization of examination management in the health analyst department of the Health Polytechnic of the Ministry of Health in Maluku. Methods. This study used a descriptive research design. This research was conducted in the health analyst department of the Maluku Health Polytechnic Ministry of Health in July - August 2019. The sample in this study were all employees and students in the Maluku Health Poltekkes Department of Health analyst with the sampling technique using total sampling. A Likert scale questionnaire was used as an instrument in the study. Results. There are respondents with more job distribution, namely 45 students (80.4%). Respondents who rated the application and website development category as very satisfied were 30 respondents (53.5%), and satisfied were 26 respondents (46.5%). Respondents who assessed the optimal management of the examination category were very satisfied with 38 respondents (67.8%), and satisfied with 18 respondents (32.2%). Conclusion. There is no relationship between the implementation of the SOP for exam management with optimal exam management, and there is a relationship between making applications and websites with optimal exam management.
Determinants of Micro, Small and Medium Enterprises (SMEs) Performance
Authors: Bakari Said Moh Agus B , Abdul Irawati , Dai Sri Indriyani S.
Published: March 2024

This study aims to analyze the influence of capital, human resources and technology on the performance of micro, small and medium enterprises (SMEs) in Gorontalo City.  The analysis method uses multiple linear regression with a crossection approach. The data used in this study was primary data sourced from 30 respondents. The results of this study show that: 1) capital has a negative insignificant effect on the performance of SMEs; 2) human resources have a positive insignificant effect on MSME performance and 3) technology has a significant positive effect on SMEs performance. This study provides practical implications for the government as a policy maker in an effort to improve the performance and empowerment of SMEs, especially in Gorontalo City.
Avaliação dos compostos bioativos polifenóis, carotenóides e glucosinolatos de hortaliças e sua importância nutricional para prevenção de doenças
Authors: Antunes Erica Ribeiro
Published: March 2024

As hortaliças, de um modo geral, possuem uma grande importância na prática de uma alimentação adequada e balanceada, o que está diretamente relacionado com os princípios básicos da segurança alimentar e nutricional, principalmente no que diz respeito ao fornecimento de vitaminas, sais minerais e fibras. Algumas hortaliças podem ser ainda, excelentes fontes de carboidratos e proteínas. Por esta razão, o presente trabalho realizará uma avaliação dos compostos bioativos polifenóis, carotenoides e glucosinolatos de hortaliças e sua importância nutricional para prevenção de doenças. Possuindo por objetivo geral, analisar os benefícios dos compostos bioativos polifenóis, carotenoides e glucosinolatos das hortaliças e sua importância nutricional para prevenção de doenças, e objetivos específicos apresentar a definição de hortaliças, sua classificação e composição nutricional; definir os compostos bioativos, apresentando os principais tipos e; apresentar a ação dos compostos bioativos na prevenção de determinadas doenças. Para atingir tais objetivos, utilizou-se por metodologia uma revisão integrativa da literatura. Com a realização da mesma, foi possível constatar que são acumuladas evidências sobre os efeitos terapêuticos dos compostos bioativos, elevando desta maneira a importância do entendimento da biodisponibilidade destes compostos in vivo.
ФОРСАЙТ ІНВЕСТИЦІЙНОЇ ПРИВАБЛИВОСТІ ЕКОНОМІКИ УКРАЇНИ: ОСНОВНІ ХАРАКТЕРИСТИКИ ТА КЛЮЧОВІ ВЕКТОРИ РОЗВИТКУ
Authors: Атамас О.П.
Published: March 2024

У статті проаналізовано концептуальні основи визначення основоположних характеристик дефініції «форсайт інвестиційної привабливості економіки держави» в контексті нівелювання рівня потенційних загроз становлення та забезпечення прогресивного розвитку економічної системи на макрорівні, розкрито сутнісну характеристику компаративного аналізу означеної дефініції, представлено інтерпретацію дефініції «форсайт інвестиційної привабливості економіки держави» як процесу економічних перетворень. Глобалізаційні зрушення в контексті трансформаційних економічних перетворень зумовлюють необхідність аналізу дефініції «форсайт» враховуючи багатоаспектність та взаємозалежність його ключових складових елементів не лише з метою залучення додаткового інвестиційного капіталу у реалізацію довгострокових інвестиційних проєктів макроекономічного рівня, а й з метою забезпечення високого рівня конкурентоспроможності держави на світовій арені, збереження її рейтингових позицій за оцінками різноманітних міжнародних агентств та асоціацій.
ПРИЧИНИ ТА НАСЛІДКИ КРИЗИ ЯК ВИКЛИК ДЛЯ СУЧАСНОЇ СИСТЕМИ ЕКОНОМІЧНОЇ БЕЗПЕКИ ПІДПРИЄМСТВА
Authors: Проць Р.Р.
Published: March 2024

Метою дослідження є характеристика особливостей причин та наслідків кризи як виклику для сучасної системи економічної безпеки підприємства. Доведено, що Криза на сучасному підприємстві — це значне і зазвичай раптове порушення нормальної діяльності або управління, яке є суттєвою загрозою його фінансовій стабільності, репутації або довгостроковому виживанню. Визначено, що антикризове управління відіграє ключову роль у підтримці фінансової стабільності, забезпечуючи наявність у підприємства необхідних ресурсів та процесів для подолання кризи. Це включає підтримку адекватних грошових резервів, диверсифікацію потоків доходів і впровадження надійних методів управління ризиками. Встановлено, що криза вимагає від підприємств не лише реагування на поточні виклики, але й проактивного підходу до зміцнення своєї системи економічної безпеки. Охарактеризовано ключові наслідки кризи для системи забезпечення економічної безпеки підприємства. Визначено, що цифрові технології суттєво вплинули на те, як підприємства переживають кризові ситуації та справляються з ними. Встановлено, що хоча цифрові технології привнесли нові вимірювання ризику, вони одночасно надали підприємствам передові інструменти для прогнозування криз, управління ними та відновлення. Виокремлено основні загрози економічній безпеці підприємства внаслідок відсутності ефективної системи антикризового управління. Доведено, що сучасна система управління економічною безпекою підприємства відіграє ключову роль у подоланні кризових ситуацій, забезпечуючи комплексний підхід до ідентифікації, аналізу та реагування на потенційні загрози. Визначено, що важливим є підтримання гнучкості та адаптивності системи, що дозволяє оперативно реагувати на зміни у зовнішньому середовищі та коригувати плани відповідно до поточної ситуації. Постійне оновлення та вдосконалення процесів, заснованих на зібраних даних та досвіді, є важливою частиною стратегії економічної безпеки.
ІНФОРМАЦІЙНЕ ЗАБЕЗПЕЧЕННЯ БЕЗПЕКОВОЇ ДІЯЛЬНОСТІ ТОРГОВЕЛЬНИХ ПІДПРИЄМСТВ: ТЕОРЕТИЧНІ ОСНОВИ
Authors: Мельник С.І. , Равлінко З.П. , Дуфенюк О.М.
Published: March 2024

Поточна складна ситуація для українських підприємств, зокрема і торговельних, обумовлена наслідками раніше домінуючого COVID-19 та актуальними сьогодні військовими діями. Швидка зміна середовища функціонування обумовлює важливість удосконалення безпекової діяльності в масштабах кожного підприємства. Результативність дій суб’єктів безпеки визначається здатністю зменшити рівень невизначеності, що потребує особливої уваги до питань організації інформаційного забезпечення. Раніше домінуюча політика, що полягала в аналізі в основному внутрішньої інформації для визначення поточного рівня безпеки та встановлення основних загроз із подальшим розроблення заходів стосовно їх ліквідації, виявилася недостатньо ефективною при вагомому випливі зовнішніх факторів. Наголошено, що особливо складна ситуація склалася для торговельних підприємств через різноспрямованість в поведінці споживачів та постачальників. На основі з’ясування змісту пов’язаних між собою понять «інформація» та «інформаційне забезпечення» розглянуто умови задоволення інформаційних потреб суб’єктів безпеки. Обґрунтовано засади приведення наповнення інформаційного середовища функціонування підприємства до потреб суб’єктів безпеки через встановлення фільтрів та відокремлення інформаційного шуму. Визначено сутнісні характеристики інформаційного забезпечення безпекової діяльності торговельного підприємства
Review of Biomechanical Studies and Finite Element Modeling of Sternal Closure Using Bio-Active Adhesives
Authors: Al-Abassi Amatulraheem , Papini Marcello , Towler Mark
Published: March 2024

The most common complication of median sternotomy surgery is sternum re-separation after sternal fixation, which leads to high rates of morbidity and mortality. The adhered sternal fixation technique comprises the wiring fixation technique and the use of bio-adhesives. Adhered sternal fixation techniques have not been extensively studied using finite element analysis, so mechanical testing studies and finite element analysis of sternal fixation will be presented in this review to find the optimum techniques for simulating sternal fixation with adhesives. The optimal wiring technique should enhance bone stability and limit sternal displacement. Bio-adhesives have been proposed to support sternal fixation, as wiring is prone to failure in cases of post-operative problems. The aim of this paper is to review and present the existing numerical and biomechanical sternal fixation studies by reviewing common sternal closure techniques, adhesives for sternal closure, biomechanical modeling of sternal fixation, and finite element modeling of sternal fixation systems. Investigating the physical behavior of 3D sternal fixation models by finite element analysis (FEA) will lower the expense of conducting clinical trials. This indicates that FEA studies of sternal fixation with adhesives are needed to analyze the efficiency of this sternal closure technique virtually.
A review of the latest insights into the mechanism of action of strontium in bone
Authors: Marx Daniella , Yazdi Alireza Rahimnejad , Papini Marcello , Towler Mark
Published: March 2024

Interest in strontium (Sr) has persisted over the last three decades due to its unique mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast function. While this mechanism of action is strongly supported by in vitro studies and small animal trials, recent large-scale clinical trials have demonstrated that orally administered strontium ranelate (SrRan) may have no anabolic effect on bone formation in humans. Yet, there is a strong correlation between Sr accumulation in bone and reduced fracture risk in post-menopausal women, suggesting Sr acts via a purely physiochemical mechanism to enhance bone strength. Conversely, the local administration of Sr with the use of modified biomaterials has been shown to enhance bone growth, osseointegration and bone healing at the bone-implant interface, to a greater degree than Sr-free materials. This review summarizes current knowledge of the main cellular and physiochemical mechanisms that underly Sr’s effect in bone, which center around Sr’s similarity to calcium (Ca). We will also summarize the main controversies in Sr research which cast doubt on the ‘dual-acting mechanism’. Lastly, we will explore the effects of Sr-modified bone-implant materials both in vitro and in vivo, examining whether Sr may act via an alternate mechanism when administered locally.

 
Deep Learning and Explainable AI Methods for Surgical Skills Assessment
Authors: Kasa Kevin
Published: March 2024

In this thesis we introduce and analyze a new annotated and multi-modal dataset of a surgical knot-tying task. We also design and develop three deep learning models, including a multi-modal model leveraging both image and time-series kinematic data that demonstrates performance comparable to expert human raters. Further, we try to open the ”black-box” of the AI models, and investigate the important features in the dataset the AI uses to make its predictions. Using a saliency-map based approach, we find that the image-based features are similar to the features used by human evaluators. As objective assessment of technical skill continues to be a growing, but resource-heavy, element of surgical education, this study is an important step towards automated surgical skill assessment, ultimately leading to reduced burden on training faculty and institutes.
Prediction Model Validation for Circular Flight Paths for CREATeV
Authors: Habib Lydia
Published: March 2024

This study focused on the analysis of flight test data collected during an 18-hour flight for CREATeV. CREATeV is an unmanned solar Clean Renewable Energy Aerial Test Vehicle that aims to achieve complete ultra-long endurance flight using 96 wing-mounted solar cells. Flight test data were extracted to understand the aircraft’s power collection and usage. A prediction model was validated by considering wind effects and position of the sun throughout a selected flight segment. The model was validated through methods discussed in this study. The validated prediction model can be applied to any circular flight to predict the power required for banking turn, solar power collected, battery charging power, aircraft bank angle and heading. A theoretical flight scenario was inputted into the validation model to demonstrate how the model may be used.
Analysis of the Dynamics and Control of a Morphing Quadrotor
Authors: Cristobal Jann Eldiemar
Published: March 2024

This paper will model a morphing quadrotor that is based on the works of Falanga etal [1]. It starts with the dynamics of a fixed geometry quadrotors. Getting a good understanding of the equations of motion for the system can help determine how each of the parameters can affect the system response. The use of multiple frames allows for simplification of the equation. This mixed frame approach and the use of rotation matrices significantly make the problem easier to solve. After learning about how each of the parameters affect the system, the inclusion of variable geometry means that the moment of inertia, the attitude controller gains, and the actuator controller methods require modifications. Using point masses to represent the major components of the quadrotor, estimation for the changing Moment of Inertia as a function of the morphing angle βk is calculated. Using Linear Quadratic Regulator, an adaptive attitude control allows for the changing gains to be possible mid-flight for better stability. Using the position vectors of the rotors with respect to the center of mass, the mapping for controller input, [T, Mφ, Mθ, Mψ]T, and rotor speed are determined. When comparing the simulation results with Falanga etal [1], the response follow a similar trend. Overall, the simulation response is adequate in showing the system behaviour when changing geometry mid-flight. Analysis in the variable thrust coefficient can get the simulation closer to the experimental results.
Empowering Multilingual Learners: A Translanguaging Approach to English Language Teaching at Kuwaiti Universities
Authors: Aljuwaisri Aishah
Published: March 2024

This study investigates the implementation of Translanguaging approaches in English language teaching at Kuwaiti universities to empower multilingual learners. Through qualitative research methods, including interviews and focus group discussions, the experiences, perceptions, and practices of English language educators regarding Translanguaging are explored. The findings reveal varying degrees of experience with Translanguaging practices among educators, with some utilizing Translanguaging regularly in their classrooms while others are less familiar with the concept. Educators express diverse perceptions of Translanguaging, with some viewing it as a valuable pedagogical approach for promoting linguistic diversity and inclusivity, while others express concerns about its potential impact on English language proficiency and standardization. The study highlights the need for targeted professional development initiatives to support educators in enhancing their understanding and implementation of Translanguaging practices. Furthermore, recommendations are provided for curriculum design, instructional strategies, and institutional support to integrate Translanguaging approaches into English language teaching at Kuwaiti universities effectively. By embracing Translanguaging as a pedagogical approach, educators can create inclusive learning environments that value students' linguistic diversity and empower multilingual learners to succeed in their English language learning journey.
Keanekaragaman Serangga pada Tanaman Kopi Liberika dengan Tiga Intensitas Naungan yang Berbeda
Authors: Khasanah Nurdiah , Windriyanti Wiwin , Yuliasmara Fitria
Published: March 2024

Budidaya kopi Liberika pada umumnya dibudidayakan di bawah naungan. Namun di beberapa daerah, budidaya kopi Liberika menggunakan sistem tanpa naungan. Perbedaan intensitas naungan akan berpengaruh terhadap iklim mikro dan keberagaman komponen organisme dan mikroorganisme termasuk keberagaman serangga. Tujuan penelitian ini adalah mengetahui perbedaan keanekaragaman serangga pada 3 intensitas naungan. Berdasarkan hasil penelitian yang dilakukan di Kebun Percobaan Wirolegi, Jember, Jawa Timur pada bulan September hingga Oktober 2022 didapatkan hasil bahwa indeks keragaman serangga pada intensitas naungan 2:1 tergolong sedang dengan nilai 1.9, sedangkan untuk intensitas naungan 1:1 dan perlakuan tanpa naungan tergolong rendah dengan nilai 1.4. Ordo serangga yang dapat dijumpai pada naungan 2:1 adalah Arachnida, Coleoptera, Diptera, Hymenoptera, dan Orthoptera dengan 10 famili serangga. Sedangkan ordo serangga yang banyak dijumpai pada naungan 1:1 dan tanpa naungan adalah Arachnida, Coleoptera, Diptera, Lepidoptera, dan Orthoptera dengan masing-masing 9 famili dan 7 famili serangga.
Kajian Teknis Dan Finansial Interkoneksi Pembangkit Listrik Tenaga Biogas Dari Palm Oil Mill Effluent (POME) Pada Sistem 20 KV Di Kabupaten Musi Rawas
Authors: Thamrin Nj. , Yusiana Venny
Published: March 2024

Using renewable energy is one way to reduce global warming. Minister of Energy and Mineral Resources Regulation No. 21 of 2016 concerning Purchase of Electricity and Biogas Power. The government has supported efforts to develop electrical energy from biogas. PT Evans Lestari is an oil palm plantation company operating in Mura with a plantation area of 9,220 ha and a mill of 60 tons/hour. In order to fulfill PLN's requirements to offer electricity supply, it is necessary to carry out a technical assessment of the connection and an economic analysis. The connection of the EBT PLT to PLN's 20 kV distribution system has been regulated in Directors' Decree No. 0357.K/DIR/2014. The benefits obtained from using DG include reducing power losses and improving the voltage profile of the distribution system. Among the types of DG that are commonly used, one of them is the Bio Gas Power Plant (PTBG) fueled by liquid palm oil waste.
Analisis Kepatuhan Koperasi Syariah Pada Implementasi Akad IMBT Ditinjauan dari Fatwa DSN MUI No. 27 Tahun 2002
Authors: Amrullah Muhammad Ilham , Sholahuddin Muhammad , Rizka Rizka
Published: March 2024

Essentially, the majority of people want to fulfill their needs for consumer or productive goods quickly and through a simple process, In this context, Islam is present as a solution for society to meet society's needs for assets through financing agreements contract al-Ijarah Muntahiyah Bi at-Tamlik (IMBT). Which aims to review the suitability of the implementation of the contract al-Ijarah Muntahiyah Bi at-Tamlik against DSN-MUI fatwa no. 27 of 2002 about IMBT. Field research is the form of research used, and the research method employed is a descriptive method with a qualitative research paradigm approach. Data was obtained through several data collection techniques, namely observation, interviews and documentation. The data analysis technique used is the Miles and Huberman analysis technique. The results of the research state that apart from the conformity of several IMBT contract implementations to the DSN-MUI Fatwa, The DSN-MUI Fatwa is not followed in a number of implementations, including the transfer of ownership at the start of the IMBT contract, the full tenant-borne maintenance costs for the rental items, and the initial intention of customers applying for IMBT contract financing, which was not to satisfy their needs for consumer or productive goods.
Hubungan Pengetahuan Ibu dengan Kejadian Stunting di Desa Sena Kecamatan Batang Kuis Kabupaten Deli Serdang
Authors: Asnawi Arifatul Aini , Putri Dea Utami , Gianing Dwene Nur , Pratiwi Dwi Amanda , Hafizah Rehana Qori , Rasyid Abdul
Published: March 2024

Stunting is a chronic nutritional problem that is recognized by having a body that is shorter than its age. Stunting occurs due to chronic lack of nutrition during the first 1000 days of life (HPK). The aim of this research is to determine the relationship between the level of maternal knowledge and the incidence of stunting in Sena Village, Batang Kuis District. This research is a quantitative research with a descriptive analytical design with a cross sectional approach. The results of this research prove that there is a relationship between maternal knowledge and the incidence of stunting in children under five in Sena Village.
PELATIHAN PENYUSUNAN PROGRAM PEMBELAJARAN MODEL PEMBELAJARAN ABAD 21 DI TK DHARMA WANITA PROVINSI BENGKULU
Authors: Nasirun M , Suprapti Anni , Indrawati Indrawati
Published: March 2024

Tujuan kegiatan pengabdian pada masyarakat ini adalah Meningkatkan kemampuan guru dalam penyusunan Rencana Pelaksanaan Pembelajaran (RPP) dalam Pembelajaran Abad 21 yang digunakan mengajar di TK. Pemecahan masalah dalam kegiatan pengabdian pada masyarakat ini dilakukan dengan melaksanakan kegiatan kegiatan pengabdian masyarakat melalui  pelatihan Model Pembelajaran Abad 21 yang diikuti para guru TK Dharma Wanita Propinsi Bengkulu. Khalayak sasaran dalam kegiatan pengabdian pada masyarakat ini adalah seluruh guru TK Dharma Wanita Provinsi Bengkulu berjumlah 13 orang guru. Metode kegiatan yang akan dilakukan dalam kegiatan pengabdian pada masyarakat ini adalah: Metode Ceramah; Metode Tanya-jawab, Penugasan (latihan) tentang penyusunan rencana pelaksanaan pembelajaran (RPP) dalam Pembelajaran Abad 21. Hasil kegiatan penyusunan rencana pembelajaran Abad 21 di TK Dharma Wanita Provinsi Bengkulu,  dan setelah dilakukan evaluasi dan penilaian serta balikan dari peserta disimpulkan kegiatan berjalan dengan baik  sesuai tujuan. Hasil penyusunan rencana pelaksanaan pembelajaran yang dibuat oleh guru berada pada kriteria baik  artinya seluruh komponen rencana pelaksanaan pembelajaran (RPP) dalam Pembelajaran Abad 21 sudah dilakukan dengan lengkap dan baik. Saran setelah kegiatan hendaknya perlu pelatihan untuk memberikan tentang komponen dan indikator atau kriteria-kriteria penyusunan rencana pelaksanaan pembelajaran Abad 21
PELATIHAN PENERAPAN KOMUNIKASI EFEKTIF ORANG TUA DAN ANAK UNTUK MENCEGAH KEKERASAN VERBAL
Authors: Fadillah Siti , Efastri Sean Marta , Filtri Heleni
Published: March 2024

Kekerasan verbal pada anak merupakan salah satu kekerasan psikis yang menyakiti perasaan atau kekerasan yang berasal dari komunikasi yang tidak baik dari orangtua. Kekerasan verbal bisa di hindari apabila orangtua bisa menerapkan komunikasi yang efektif. Komunikasi efektif yang diterapkan orang tua dengan anak sangat penting dan berpengaruh bagi perkembangan kepribadian anak. Peningkatan pengetahuan komunikasi efektif dapat dilakukan dengan pelatihan. Kegiatan peningkatan kemampuan komunikasi efektif untuk mencegah kejadian kekerasan verbal dilakukan dengan metode pelatihan yang di laksanakan pada mitra ibm yaitu para orang tua dan guru di lingkungan HIMPAUDI kecamatan Rumbai Pesisir. Para peserta pelatihan adalah orang tua  dan guru di lingkungan HIMPAUDI kecamatan rumbai pesisir yang memiliki anak usia pra sekolah sebanyak 40 orang. Pengukuran pengetahuan dilakukan dengan metode pre test dan post test. Pre test telah dilakukan sebelum kegiatan dimulai, telah post test dilakukan setelah kegiatan dimulai. Pre test pengetahuan komunikasi efektif mayoritas kurang (43,6 %), pengetahuan kekerasan verbal  yaitu (55,4 %). Hasil kegiatan post test yang dilaksanakan setelah pelatihan didapatkan hasil pengetahuan komunikasi efektif mayoritas baik yakni (92,9 %), pengetahuan kekerasan verbal mayoritas baik (95,3 %).
La educación afectiva para el desarrollo de la inteligencia emocional
Authors: Mejia-Flores Mariela , Sánchez-Manobanda Katty , Gómez-De la Torre María , Velastegui-Hernández Rommel
Published: March 2024

En este artículo de investigación se realizó mediante una búsqueda de literatura acorde al tema y sus variables. Esta revisión profundiza un marco conceptual esencial para diseñar prácticas educativas más inclusivas y centradas en el bienestar emocional de los estudiantes. La pedagogía afectiva se enfoca en el desarrollo de la inteligencia emocional, cultivando habilidades clave como la autoconciencia y la empatía. Los docentes desempeñan un papel fundamental al fomentar la comprensión de las emociones y promover relaciones interpersonales saludables. Además, se utiliza un enfoque descriptivo ya que es un proceso basado en la búsqueda, análisis y recopilación de información centrándose en la revisión de documentos, libros, artículos científicos, tesis y fuentes confiables, no implica la realización de experimentos. El enfoque sistemático nos facilitara para la recopilación y sintetizar de manera exhaustiva y rigurosa la evidencia científica existente sobre un tema específico. Por último, el desarrollo de la inteligencia emocional en los niños es esencial para que puedan lidiar con los desafíos de la vida y promover su bienestar emocional. Este tipo de investigación contribuye al desarrollo de prácticas pedagógicas más inclusivas y centradas en el bienestar emocional de los estudiantes.
Analyzing Women’s Views in a Democratic Environments (An Inquiry into Women’s Organizations in East Kalimantan)
Authors: Akhyar Ramadiva Muhammad , Hayati Afita Nur , Inayah Sitti Syahar , Wijaya Ida Suryani
Published: March 2024

Investigating women’s participation in politics might be beneficial for the improvements of communication studies, especially in political communication studies. This research’s objective is to analyze the involvement of a group of women in a religious Islamic movement in East Kalimantan, Indonesia. This research applied a descriptive qualitative research design by conducting semi- structured interviews to ten women from two political women groups in East Kalimantan. The results of the research suggest that the informants posit their acceptance to a particular male and female legislative candidates due to these candidates’ stances in religious beliefs and the candidates’ credibilities. The results suggest that these informants have a strong awareness to actively participate in politics, suggesting that women are aware of the importance of politics in their daily life.
Shielding Effectiveness of HV-HF Transformer for Accelerator Applications
Authors: Rajan Rehim N. , Dewangan S. , Das S. H. , Mitra A. , Sharma D. K. , Patel R. , Bakhtsingh R. I. , Saroj P. , Sharma A.
Published: March 2024

High-voltage high-frequency transformers are employed in DC accelerators. The high frequency produced by the inverter at lower voltage is stepped up to several tens of kilovolts using step-up transformers. These transformers are subjected to high-frequency transients from high-voltage multiplier columns. Electrostatic shielding is very effective in common mode noise reduction. However, in accelerator applications, shielding effectiveness obtained using conductive shields is found compromised in practice. This paper investigates the reasons behind this phenomenon and explores remedial measures.
Investigation of Planar Antenna Performances on Commercially Available Dielectric Materials
Authors: Subin S. , Goyal Vijay K. , Sanadhya Vivek
Published: March 2024

Planar RF antennas with their conformal geometry, good RF performances and ease of construction find a wide range of applications ranging from mobile phones to RADAR and wearable electronic gadgets to medical implant devices. The selection of a suitable dielectric material is by far the most crucial step in the antenna design process to achieve the desired RF characteristics. The directivity, efficiency and bandwidth of an antenna depend on the substrate dielectric constant, loss tangent and material thickness. This paper investigates the RF performances of two planar antennas designed using two commercially available dielectric materials namely RT Duroid and FR4 with a full wave 3D EM simulation tool. The results show the superior RF characteristics of the antenna designed using RT Duroid over FR4. The antenna designed with RT Duroid substrate is fabricated and the measurement results obtained are found to be in good agreement with the simulation results.
Optimal selection of specimens for metagenomic next-generation sequencing in diagnosing periprosthetic joint infections
Authors: Tan Jun , Wu Lingxiao , Zhan Lijuan , Sheng Minkui , Tang Zhongxin , Xu Jianzhong , Ma Haijun
Published: March 2024

Objective

This study aimed to assess the diagnostic value of metagenomic next-generation sequencing (mNGS) across synovial fluid, prosthetic sonicate fluid, and periprosthetic tissues among patients with periprosthetic joint infection (PJI), intending to optimize specimen selection for mNGS in these patients.

Methods

This prospective study involved 61 patients undergoing revision arthroplasty between September 2021 and September 2022 at the First Affiliated Hospital of Zhengzhou University. Among them, 43 cases were diagnosed as PJI, and 18 as aseptic loosening (AL) based on the American Musculoskeletal Infection Society (MSIS) criteria. Preoperative or intraoperative synovial fluid, periprosthetic tissues, and prosthetic sonicate fluid were collected, each divided into two portions for mNGS and culture. Comparative analyses were conducted between the microbiological results and diagnostic efficacy derived from mNGS and culture tests. Furthermore, the variability in mNGS diagnostic efficacy for PJI across different specimen types was assessed.

Results

The sensitivity and specificity of mNGS diagnosis was 93% and 94.4% for all types of PJI specimens; the sensitivity and specificity of culture diagnosis was 72.1% and 100%, respectively. The diagnostic sensitivity of mNGS was significantly higher than that of culture (X2 = 6.541, P=0.011), with no statistically significant difference in specificity (X2 = 1.029, P=0.310). The sensitivity of the synovial fluid was 83.7% and the specificity was 94.4%; the sensitivity of the prosthetic sonicate fluid was 90.7% and the specificity was 94.4%; and the sensitivity of the periprosthetic tissue was 81.4% and the specificity was 100%. Notably, the mNGS of prosthetic sonicate fluid displayed a superior pathogen detection rate compared to other specimen types.

Conclusion

mNGS can function as a precise diagnostic tool for identifying pathogens in PJI patients using three types of specimens. Due to its superior ability in pathogen identification, prosthetic sonicate fluid can replace synovial fluid and periprosthetic tissue as the optimal sample choice for mNGS.
A short review on CRP synthesis inhibition in cardiovascular disease
Authors: Zaczkiewicz Myron , Zimmermann Oliver , Torzewski Jan
Published: March 2024

C-reactive Protein (CRP) is synthesized in the liver. Synthesis is stimulated via the IL-1ß/IL6 pathway. CRP activates the complement system via C1q and macrophages via Fcγ receptors. Since elevated CRP plasma levels are associated with increased cardiovascular risk, CRP may play a causal role in cardiovascular disease. One approach to transfer these observations into standard medical care would be to generate hepatic CRP synthesis inhibitors and use them in controlled clinical trials. Despite huge pharmacological efforts, the search for CRP synthesis inhibitors proved to be difficult. First, the antisense oligonucleotide RNA technology, although a promising idea, has not yet led to results feasible for clinical practice. Secondly, high throughput screening assays in search for hepatic CRP inhibitors were limited by the fact that primary human hepatocytes do not adequately grow in vitro. Use of genetically engineered hepatoma cells led to the observation that cardiac glycosides are capable of inhibiting CRP synthesis. Because of patent law considerations, however, pharmaceutical companies had limited interest in further pursuing this possible path. Upstream inhibition of IL-1ß and IL-6 by antibodies has shown positive results in cardiovascular clinical trials, but because of side effects none of these antibodies has yet received FDA approval. In contrast, long-term colchicine treatment, though not being a CRP-specific approach, has recently been approved by the FDA. Taken together, there is no compelling evidence until today that hepatic CRP synthesis can specifically, effectively and safely be inhibited in vivo in human medicine. Currently, other avenues appear more promising. Here, we summarize contemporary approaches to inhibit CRP synthesis and potential goals for future clinical trials.
Establishment and verification of a nomogram that predicts the risk for coronary slow flow
Authors: Yu Jiang , Ran Yangshan , Yi Dan , Yang Chengyu , Zhou Xiang , Wang Sibin , Li Hao , Yu Wensi , Sun Zhijun , Zhang Zhengbo , Yan Muyang
Published: March 2024

Background

Coronary slow flow (CSF) has gained significance as a chronic coronary artery disease, but few studies have integrated both biological and anatomical factors for CSF assessment. This study aimed to develop and validate a simple-to-use nomogram for predicting CSF risk by combining biological and anatomical factors.

Methods

In this retrospective case-control study, 1042 patients (614 CSF cases and 428 controls) were randomly assigned to the development and validation cohorts at a 7:3 ratio. Potential predictive factors were identified using least absolute shrinkage and selection operator regression and subsequently utilized in multivariate logistic regression to construct the nomogram. Validation of the nomogram was assessed by discrimination and calibration.

Results

N-terminal pro brain natriuretic peptide, high density lipoprotein cholesterol, hemoglobin, left anterior descending artery diameter, left circumflex artery diameter, and right coronary artery diameter were independent predictors of CSF. The model displayed high discrimination in the development and validation cohorts (C-index 0.771, 95% CI: 0.737-0.805 and 0.805, 95% CI: 0.757-0.853, respectively). The calibration curves for both cohorts showed close alignment between predicted and actual risk estimates, demonstrating improved model calibration. Decision curve analysis suggested high clinical utility for the predictive nomogram.

Conclusion

The constructed nomogram accurately and individually predicts the risk of CSF for patients with suspected CSF and may be considered for use in clinical care.
Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea
Authors: Tao MengShi , Dong Xiaoqi , Tu Jinjing , Fang Qing , Shao Chuan
Published: March 2024

Background

Obstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with normal blood pressure have not been fully defined.

Methods

This study retrospectively analyzed OSA patients diagnosed for the first time in Lihuili Hospital Affiliated to Ningbo University from 2016 to 2020. Patients were divided into an OSA group with hypertension and an OSA group without hypertension. The sociodemographic information, clinical symptoms, comorbidities, and polysomnography results of the two groups were compared. The independent risk factors associated with hypertension in patients with OSA were explored.

Results

A total of 1108 patients with OSA initially diagnosed were included in the study, including 387 with hypertension and 721 without. Compared with OSA patients without hypertension, OSA patients with hypertension were older; had a higher body mass index (BMI) and Epworth sleepiness score (ESS); a higher incidence of nocturia; and a higher proportion of diabetes mellitus, coronary heart disease, and cerebrovascular disease. Multivariate analysis showed age (odds ratio [OR]:1.06, 95% confidence interval [CI]:1.04-1.08), BMI (OR:1.17, 95% CI:1.11-1.23), ESS score (OR:0.97, 95%CI: 0.94-1.00) and nocturia symptoms (OR:1.64, 95% CI:1.19-2.27) was independently associated with hypertension in OSA patients, and comorbid diabetes (OR: 3.86, 95% CI: 2.31-6.45), coronary heart disease (OR: 1.90, 95% CI:1.15-3.16), and ischemic stroke (OR: 3.69,95% CI:1.31-10.40) was independently associated with hypertension in OSA patients.

Conclusion

Compared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease.
Advances in targeted therapy and biomarker research in thyroid cancer
Authors: Guo Mei , Sun Yuqi , Wei Yuyao , Xu Jianxin , Zhang Chun
Published: March 2024

Driven by the intricacy of the illness and the need for individualized treatments, targeted therapy and biomarker research in thyroid cancer represent an important frontier in oncology. The variety of genetic changes associated with thyroid cancer demand more investigation to elucidate molecular details. This research is clinically significant since it can be used to develop customized treatment plans. A more focused approach is provided by targeted therapies, which target certain molecular targets such as mutant BRAF or RET proteins. This strategy minimizes collateral harm to healthy tissues and may also reduce adverse effects. Simultaneously, patient categorization based on molecular profiles is made possible by biomarker exploration, which allows for customized therapy regimens and maximizes therapeutic results. The benefits of targeted therapy and biomarker research go beyond their immediate clinical impact to encompass the whole cancer landscape. Comprehending the genetic underpinnings of thyroid cancer facilitates the creation of novel treatments that specifically target aberrant molecules. This advances the treatment of thyroid cancer and advances precision medicine, paving the way for the treatment of other cancers. Taken simply, more study on thyroid cancer is promising for better patient care. The concepts discovered during this investigation have the potential to completely transform the way that care is provided, bringing in a new era of personalized, precision medicine. This paradigm shift could improve the prognosis and quality of life for individuals with thyroid cancer and act as an inspiration for advances in other cancer types.
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation
Authors: Vos Winnie G. , van Os Bram W. , den Toom Myrthe , Beckers Linda , van Roomen Cindy P.A.A. , van Tiel Claudia M. , Mohapatra Bhopal C. , Band Hamid , Nitz Katrin , Weber Christian , Atzler Dorothee , de Winther Menno P.J. , Bosmans Laura A. , Lutgens Esther , Seijkens Tom T.P.
Published: March 2024

Introduction

Atherosclerosis is a lipid-driven inflammatory disease of the arterial wall, and the underlying cause of the majority of cardiovascular diseases. Recent advances in high-parametric immunophenotyping of immune cells indicate that T cells constitute the major leukocyte population in the atherosclerotic plaque. The E3 ubiquitin ligase Casitas B-lymphoma proto-oncogene-B (CBL-B) is a critical intracellular regulator that sets the threshold for T cell activation, making CBL-B a potential therapeutic target to modulate inflammation in atherosclerosis. We previously demonstrated that complete knock-out of CBL-B aggravated atherosclerosis in Apoe-/- mice, which was attributed to increased macrophage recruitment and increased CD8+ T cell activation in the plaque.

Methods

To further study the T cell specific role of CBL-B in atherosclerosis, Apoe-/- CD4creCblbfl/fl (Cbl-bcKO) mice and Apoe-/-CD4WTCblbfl/fl littermates (Cbl-bfl/fl) were fed a high cholesterol diet for ten weeks.

Results

Cbl-bcKO mice had smaller atherosclerotic lesions in the aortic arch and root compared to Cbl-bfl/fl, and a substantial increase in CD3+ T cells in the plaque. Collagen content in the plaque was decreased, while other plaque characteristics including plaque necrotic core, macrophage content, and smooth muscle cell content, remained unchanged. Mice lacking T cell CBL-B had a 1.4-fold increase in CD8+ T cells and a 1.8-fold increase in regulatory T cells in the spleen. Splenic CD4+ and CD8+ T cells had increased expression of C-X-C Motif Chemokine Receptor 3 (CXCR3) and interferon-γ (IFN-γ), indicating a T helper 1 (Th1)-like/effector CD8+ T cell-like phenotype.

Conclusion

In conclusion, Cbl-bcKO mice have reduced atherosclerosis but show increased T cell accumulation in the plaque accompanied by systemic T cell activation.
Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice
Authors: Preite Nycolas Willian , Borges Bruno Montanari , Kaminski Valéria de Lima , Ayupe Marina Caçador , Gonçalves Leonardo Mandu , dos Santos Bianca Vieira , Fonseca Dennyson Leandro M. , Filgueiras Igor Salerno , Salgado Caio Loureiro , Muxel Sandra Marcia , Cabral-Marques Otavio , da Fonseca Denise Morais , Loures Flávio Vieira , Calich Vera Lúcia Garcia
Published: March 2024

Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) are the central classical checkpoint inhibitory (CPI) molecules used for the control of neoplasms and some infectious diseases, including some fungal infections. As the immunosuppression of severe paracoccidioidomycosis (PCM), a chronic granulomatous fungal disease, was shown to be associated with the expression of coinhibitory molecules, we hypothesized that the inhibition of CTLA-4 and PD-1 could have a beneficial effect on pulmonary PCM. To this end, C57BL/6 mice were infected with Paracoccidioides brasiliensis yeasts and treated with monoclonal antibodies (mAbs) α-CTLA-4, α-PD-1, control IgG, or PBS. We verified that blockade of CTLA-4 and PD-1 reduced the fungal load in the lungs and fungal dissemination to the liver and spleen and decreased the size of pulmonary lesions, resulting in increased survival of mice. Compared with PBS-treated infected mice, significantly increased levels of many pro- and anti-inflammatory cytokines were observed in the lungs of α-CTLA-4-treated mice, but a drastic reduction in the liver was observed following PD-1 blockade. In the lungs of α-CPI and IgG-treated mice, there were no changes in the frequency of inflammatory leukocytes, but a significant reduction in the total number of these cells was observed. Compared with PBS-treated controls, α-CPI- and IgG-treated mice exhibited reduced pulmonary infiltration of several myeloid cell subpopulations and decreased expression of costimulatory molecules. In addition, a decreased number of CD4+ and CD8+ T cells but sustained numbers of Th1, Th2, and Th17 T cells were detected. An expressive reduction in several Treg subpopulations and their maturation and suppressive molecules, in addition to reduced numbers of Treg, TCD4+, and TCD8+ cells expressing costimulatory and coinhibitory molecules of immunity, were also detected. The novel cellular and humoral profiles established in the lungs of α-CTLA-4 and α-PD-1-treated mice but not in control IgG-treated mice were more efficient at controlling fungal growth and dissemination without causing increased tissue pathology due to excessive inflammation. This is the first study demonstrating the efficacy of CPI blockade in the treatment of pulmonary PCM, and further studies combining the use of immunotherapy with antifungal drugs are encouraged.