bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing the Legal Implications of the Open Proportional System in Indonesian Legislative Elections: A Focus on Political Liberalization and Corruption
Authors: Hannan Abd
Published: November 2023

The study focuses on discussing the problem of legal implementing an open proportional election system in legislative elections in Indonesia, its role and influence on the emergence of political anomalies within the parliament, in this case political liberalization and corruption. The study question is about the dynamics of implementing an open proportional system in the context of elections and how the legislative elections are correlated with the practice of political liberalization and corruption in Indonesia. This study is qualitative research conducted using a library approach. As a result, elections with an open proportional system contain several weaknesses and deficiencies that have the potential to give rise to corrupt practices within the board, both at the regional central level. The potential for the emergence of corrupt practices in open proportional system elections is caused by two things; First, open proportional electoral systems tend to be liberal and capitalist. Competition for leadership tends to focus on pragmatic areas that are centered on money and power relations, no longer in productive areas such as ideas, thoughts, ideas. Second, because of these liberalization and capitalization practices, political costs and expenses soared beyond rational and reasonable limits. In the end, uncontrolled political costs become a financial burden later that they must pay off and return.Studi fokus membahas problem implikasi hukum sistem proporsional terbuka dalam pemilu legislatif di Indonesia, peran dan pengaruhnya terhadap munculnya anomali politik di kalangan dewan, dalam hal ini adalah liberalisasi politik dan korupsi. Pertanyaan kajian adalah dinamika penerapan sistem proporsional terbuka dalam konteks Pemilu serta bagaimana korelasi dalam pemilu legislatif dengan praktik liberalisasi politik dan korupsi di Indonesia. Studi ini merupakan penelitian kualitatif yang dilakukan dengan pendekatan kepustakaan. Hasilnya, gelaran pemilu dengan sistem proporsional terbuka memuat sejumlah kelemahan dan kekurangan yang berpotensi besar menimbulkan praktik korupsi di kalangan dewan, baik di tingkat pusat daerah.  Potensi munculnya praktik korupsi dalam pemilu sistem proporsional terbuka disebabkan oleh dua hal; pertama, sistem pemilu proporsional terbuka cenderung liberal dan kapitalis. Kompetisi kepemimpinan cenderung berkutat di wilayah-wilayah prgamatis yang berpusat pada uang dan relasi kekuasaan, bukan lagi ada di wilayah-wilayah produktif semisal ide, pemikiran, gagasan. Kedua, akibat dari praktik liberalisasi dan kapitalisasi tersebut, ongkos dan biaya politik melambung tinggi melebihi batas rasional dan kewajaran. Pada akhirnya, biaya politik tidak terkontrol menjadi beban finansial di kemudian hari yang harus mereka lunasi dan kembalikan.
Thlaspi harungalipii (Brassicaceae), A New Species from Turkey
Authors: KARAİSMAİLOĞLU Cengiz
Published: November 2023

Thlaspi harungalipii sp. nova (Brassicaceae) is described and illustrated from Southern of Turkey. This taxon is similar to T. violascens, from which it clearly differs in flower and fruit characters. In this study, the seed micromorphological and anatomical characters, and phylogenetic relations within the genus based on the nuclear-encoded ribosomal internal transcribed spacer region of the new species are determined. Furthermore, the IUCN category of the new species is discussed, and its distribution is mapped.
Evaluation of Oxidative/Nitrosative Stress Parameters and Histopathological, Immunohistochemical Effects on Cisplatin-Induced Lung Toxicity in Rats
Authors: YILDIZ DALGINLI Kezban , ÖZTÜRKLER Melek , BEŞEREN Hatice , ADALI Yasemen , ATAKİSİ Onur
Published: November 2023

The main focus of this study is to investigate oxidative/nitrosative stress and antioxidant effects and immunohistochemical effects in cisplatin-induced lung toxicity. In the study, 12 male Sprague Dawley rats, 2 months old, were divided into two groups: control (n=6) and cisplatin (n=6). Isotonic solution was administered to control and cisplatin 10 mg/kg single dose intraperitoneal to cisplatin group. Reducte glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels were determined by spectrophotometricmethod in the lung tissues taken. Paraffin blocks were made from lung tissues and stained with hematoxylin-eosin (HE) staining. Immunohistochemically, p53, CD3, CD20, Bcl-2 ve Ki67 were evaluated. It was found that cisplatin administration alone had no effect on MDA and GSH values in the lung tissue of rats, and NO levels were significantly increased (P
The Effect of Nanofluids on Energy Efficiency in Thermal Systems: The Evaluation of the Experimental Data with Thermal and Hydrodynamic Performance Criteria
Authors: ÜNVERDİ Murat , KÜÇÜK Hasan , YILMAZ Mehmet Senan
Published: November 2023

The energy efficiency of heat exchangers has become crucial in industrial applications due to ever-increasing energy costs. Therefore, various methods have been developed to enhance heat transfer and accelerate the process (shortening the time), reduce the size of heat exchangers, and increase energy (fuel) efficiency. In recent years, researchers have recommended nanofluid suspensions in place of common heat transfer fluids to improve energy efficiency. Nanofluid suspensions are obtained by adding nanometer-sized particles (less than 100 nm in at least one dimension) to heat transfer fluids. This study focused on experimental data in the literature to investigate the effects of nanofluids on transferred thermal power and required pumping power in heat exchangers. The relationship between the transferred thermal power and the pumping power was defined by two different performance criteria (Performance Evaluation Criterion-PEC and Energy Efficiency Criterion-EEC), allowing us to scrutinize the effects of nanofluids in thermal systems on energy efficiency (energy consumption) from a more realistic perspective. The results show that nanofluids are more disadvantageous than conventional heat transfer fluids in terms of the energy budget in industrial applications. It is concluded that nanofluids can be used in special applications where those disadvantages are insignificant.
The integrity management toolbox in action: a study of 22 urban water service cases
Authors: Avello Pilar , Allakulov Umrbek , Barreto-Dillon Leonellha , Das Binayak , Hermann-Friede Janek , Hubendick Lotten , Feuerstein Lotte , Jiménez Fdez de Palencia Alejandro
Published: November 2023

Water integrity refers to the ethical, professional, and transparent use of power and resources to ensure the sustainable and equitable provision of water services. The Integrity Management (IM) Toolbox is a tool that has been adopted to initiate IM reforms within water utilities. This paper reviews the application of the IM Toolbox application in 22 urban utilities across 7 countries from 2013 to 2018, focusing on integrity risks, selected tools, and the success and challenges faced by these utilities. Common integrity risks were identified in Operations and Consumer Relations, and corresponding tools were employed in Human Resources and Consumer Relations. Within 1 year, over two-thirds of the utilities implemented 70% or more of their action plans, indicating positive progress. However, obstacles such as staff rotation and reliance on internal champions provide obstacles to continued implementation. Despite challenges, certain utilities demonstrated notable medium-term improvements. To further advance water integrity, integrating the IM Toolbox with other utility-level efficiency processes is recommended. Additionally, supporting sectoral regulatory measures can contribute to overall integrity enhancement. By effectively addressing integrity risks and adopting comprehensive approaches, water utilities can enhance their ability to provide safe and sustainable water services, while promoting transparency and equity.
A comprehensive review on the sequestration of dyes from aqueous media using maize-/corn-based adsorbents
Authors: Iwuozor Kingsley O. , Umeh Chisom T. , Emmanuel Stephen Sunday , Emenike Ebuka Chizitere , Egbemhenghe Abel U. , Ore Odunayo T. , Micheal Taiwo Temitayo , Omoarukhe Fredrick O. , Sagboye Patience A. , Ojukwu Victor E. , Adeniyi Adewale George
Published: November 2023

Corn or maize (Zea mays L.) is the most significant grain crop worldwide after wheat and rice. It is widely cultivated and consumed as food, feed, and industrial raw material, along with the emission of a large quantity of corn waste. Such abundant, renewable, and cheap wastes with unique chemical compositions can be efficiently converted into adsorbents for the elimination of dye-contaminated water. This article represents an extensive review of the use of corn/maize waste-derived adsorbents for the sequestration of dyes from aqueous media. This study addressed the utilization of corn residues, including cob, stalk, straw, husk, and silk, as precursors for adsorbents. The adsorption behaviour, mechanism, and regeneration of the studied corn adsorbent/dye systems were identified. It was observed that the most common forms of corn/maize-derived adsorbents that have been utilized for the sequestration of dyes include biosorbents, biochars, activated carbons, and composites. The highest adsorption capacity (1,682.7 mg/g) for dye (methylene blue) sequestration was obtained using a corn husk composite-based adsorbent. Important findings and future ideas are finally mentioned for the corn/maize-based materials and their application as adsorbents for dye removal.
QSAR Studies of Nitric Oxide Synthase Inhibitors
Authors: Tsopka Ioanna-Chrysoula , Hadjipavlou-Litina Dimitra
Published: November 2023

Background::

Nitric oxide is a free radical bioregulator controlling homeostasis, vasodilation,
and inhibition of platelet aggregation, significantly implicated in the nervous and immune
system functionality. In vivo it is produced by nitric oxide synthases (NOSs).

Objective::

Overproduction of nitric oxide is linked to several inflammatory, immunological, and
neurodegenerative diseases and for that, various compounds have been synthesized as inhibitors
of NOSs. In this review, the QSAR analyses were summarized in a variety of compounds as potent
inhibitors of NOSs, and the models derived through 1D, 2D and 3D QSAR analyses.

Conclusion::

Ten groups of various NOS inhibitors and 17 1D, 2D, and 3D QSAR models and
analyses were presented and discussed. A lack of hydrophobic terms was noticed in most of the
cases. Chemical substituents were selected considering the increase either of the hydrophilicity
and/or of hydrophobicity, bulkiness supported steric interactions, and point to potent inhibitors.
CMR (Calculated Molar Refractivity) a steric variable, with a negative sign, underlines the critical
effects participating on (in) an active site on the enzymes. Indicator variables imply the influence
of specific structural moieties. Electronic parameters were found to be significant.
Adaptive Autonomic and Neuroplastic Control in Diabetic Neuropathy:
A Narrative Review
Authors: Marsili Francesca , Potgieter Paul , Birkill Corlius Fourie
Published: November 2023

Background:

Type 2 diabetes mellitus (T2DM) is a worldwide socioeconomic burden,
and is accompanied by a variety of metabolic disorders, as well as nerve dysfunction referred
to as diabetic neuropathy (DN). Despite a tremendous body of research, the pathogenesis
of DN remains largely elusive. Currently, two schools of thought exist regarding the pathogenesis
of diabetic neuropathy: a) mitochondrial-induced toxicity, and b) microvascular damage.
Both mechanisms signify DN as an intractable disease and, as a consequence, therapeutic approaches
treat symptoms with limited efficacy and risk of side effects.

Objective:

Here, we propose that the human body exclusively employs mechanisms of adaptation
to protect itself during an adverse event. For this purpose, two control systems are defined,
namely the autonomic and the neural control systems. The autonomic control system responds
via inflammatory and immune responses, while the neural control system regulates neural signaling,
via plastic adaptation. Both systems are proposed to regulate a network of temporal and
causative connections which unravel the complex nature of diabetic complications.

Results:

A significant result of this approach infers that both systems make DN reversible, thus
opening the door to novel therapeutic applications.
Effectiveness of Probiotic Therapy in the Management of Periodontal
Disease in Diabetic Patients: A Scoping Review
Authors: de Brito Avelino Luanny , Rodrigues Katryne Targino , da Silva Cruz Natália Teixeira , Martins Agnes Andrade , de Aquino Martins Ana Rafaela Luz
Published: November 2023

Background:

Probiotics can compete with periodontal pathogens in the formation of
dental biofilm, and they are able to modulate local and systemic immune responses. Thus, its use
in diabetic patients with periodontal disease (PD) can overcome the limitations of conventional
periodontal treatment.

Objective:

This scoping review aimed to understand the extent and type of evidence in relation to
the effects of probiotic therapy on periodontal and glycaemic parameters of diabetic patients with
PD.

Methods:

An electronic search was performed in the following databases: Cochrane Library, EMBASE, Virtual Health Library (including LILACS and BBO), PubMed (including Medline), Scopus, Web of Science, and Google Scholar. The review included clinical trials on patients with type
2 diabetes, diagnosed with gingivitis or periodontitis, who received probiotic therapy as a single
therapy or adjuvant to scaling and root planning, and on whom the analyses of clinical periodontal,
immunological, microbiological, or glycaemic parameters were performed. Results: The electronic
search yielded a total of 1165 articles. After removing duplicate titles and performing systematic
screening, 6 studies were included in the qualitative summary. Probiotic administration improved
clinical periodontal parameters (bleeding on probing and probing depth), oxidative stress markers,
and inflammatory cytokines (IL-8, IL-10, and TNF-α) in relation to control groups. Experimental
groups were also more advantageous in reducing the frequency of periodontopathogenic bacteria.
However, the evidence of probiotics in decreasing glycated hemoglobin is still uncertain.

Conclusion:

Probiotics may provide safe additional benefits to periodontal parameters of patients
with type 2 diabetes and periodontal disease
Cardiovascular Risk Related to Glomerular Hyperfiltration in Nondiabetic
Individuals: Increasing Visibility is Crucial
Authors: Valtuille Rodolfo
Published: November 2023

Glomerular hyperfiltration (GHF), defined by different estimation formulas, has been widely studied as a predictor of proteinuria and progression to chronic kidney disease (CKD) in diabetic patients. GHF is also an important cardiovascular (CV) risk factor and is related to all-cause mortality in non-diabetic populations; however, the upper limit of glomerular filtration rate (GFR) above which it indicates the presence of GHF is weakly defined. This higher risk is as high as in the intermediate stages of CKD and is greater than the presence of diabetes or smok-ing and is still present in non-albuminuria patients. The original Chronic Kidney Disease Epide-miology Collaboration (CKD-EPI) estimation GFR formula showed lower error at higher glo-merular filtration (GF) values, was the most used in population studies, and behaved as a better risk predictor. In our review (including approximately 3.6 million individuals), higher GFR val-ues related to increased mortality risk varied from 106.6 to 113.7 ml/min, which are usually not considered risk values for standard guidelines in non-albuminuric patients. However, the lack of consensus on a GF cutoff value, as well as its variability due to sex and progressive reduction with age, affect the knowledge of this serious phenomenon in clinical practice. Although the el-derly population is not exempted from the effects of GHF, the search for this phenomenon should be intensified in middle-aged populations because of their lower disease burden, where this situation may be more evident, and the possibility of reversing the consequences is greater. A population group often considered healthy includes obese people, essential hypertensives, smokers, and carriers of fatty liver, where the GHF phenomenon is frequent and is associated with CV disease, kidney disease, and higher mortality. Increasing its visibility by the medical community is essential to reduce the effects of GHF, emphasizing more frequent controls and implementing general measures that include strict control of hypertension, Na restriction, rich in vegetables diets and increased physical activity. Initiatives to confirm the beneficial effects of sodium-glucose cotransporter-2 inhibitors to treat isolated GHF would be an important break-through in reducing the severe consequences of this phenomenon.
The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical
Cancer
Authors: Najafi Sajad , Ghaedrahmati Farhoodeh , Abouali Gale Dari Mahrokh , Farzaneh Maryam , Mohammad Jafari Razieh
Published: November 2023

Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the
fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease
influenced by various genetic, epigenetic, and environmental factors. While treatment options
such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains
poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the
role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs
(circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting
miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells,
making them a promising biomarker for diagnosis and treatment. This review provides an overview
of the functional roles of circRNAs in the context of cervical cancer.
Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases
Authors: Sun Xieyin , Lin Zhaoyi , Xu Nuo , Chen Yinqi , Bian Saiyan , Zheng Wenjie
Published: November 2023

:

Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various
diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased
attention due to their high activity and easy accessibility. Among them, dental pulp stem
cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative
capacities. Following their inspiring performance in animal models and clinical trials, DPSCs
show pharmacological potential in regenerative medicine. In this review, we have generalized the
sources, heterogeneity, and biological characteristics of DPSCs, as well as compared them with
other types of dental stem cells. In addition, we summarized the application of DPSCs in digestive
diseases (such as liver, esophageal, and intestinal diseases), highlighting their regenerative and
pharmacological potential based on the existing preclinical and clinical evidence. Specifically, DPSCs
can be home to injured or inflamed tissues and exert repair and regeneration functions by facilitating
immune regulation, anti-inflammation, and directional differentiation. Although DPSCs
have a rosy prospect, future studies should handle the underlying drawbacks and pave the way for
the identification of DPSCs as novel regenerative medicine.
Development of 7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives Using
QSARINS Tool as BTK Inhibitors for the Treatment of Rheumatoid
Arthritis
Authors: Patil Shital M. , Asgaonkar Kalyani. D. , Magdum Pradnya , Chinde Vaishnavi , Edake Aishwarya , Naik Akshata
Published: November 2023

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized
by inflammation of the joints, leading to pain, swelling, and joint deformity. Effective management
of RA involves the use of disease-modifying drugs that can slow down disease progression and
alleviate symptoms. Among the potential targets for RA treatment is Bruton's tyrosine kinase (BTK),
which plays a crucial role in B-cell signalling and contributes to the pathogenesis of RA.

Aim:

QSARINS (QSAR-INSUBRIA) is software used for the development and validation of Quantitative Structure-Activity Relationship (QSAR) analysis. In the present work, this software was explored for pharmacophore optimization of the pyrrolo-pyrimidine nucleus for anti-rheumatoid activity

Methods:

A series of pyrrolo-pyrimidine derivatives were used to build the QSAR models. These mod-els were generated to identify structural features that correlate significantly with the activity. We followed the assessment of statistical parameters to ensure thorough validation of all the QSAR models. The QSAR models demonstrating better statistical performance were selected, and descriptors of these models were analysed.

Results:

The results showed that the QSAR models were highly statistically robust and exhibited a
strong external predictive ability. Their structural features were also deduced.

Conclusion:

This QSAR study provided crucial information about the specific molecular features that can be used for the optimization of the pharmacophores. This research provides valuable insights into the structural features essential for BTK inhibition and paves the way for the design and development of novel anti-rheumatic agents targeting BTK in RA.
Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation
Authors: Monteiro Kadja Luana Chagas , de Aquino Thiago Mendonça , da Silva-Júnior Edeildo Ferreira
Published: November 2023

Neurodegenerative conditions like Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS) encompass disorders characterized by the degeneration of
neurons in specific circumstances. The quest for novel agents to influence these diseases, particularly
AD, has unearthed various natural compounds displaying multifaceted activities and diverse
pharmacological mechanisms. Given the ongoing extensive study of pathways associated with the
accumulation of neurofibrillary aggregates and amyloid plaques, this paper aims to comprehensively
review around 130 studies exploring natural products. These studies focus on inhibiting the formation
of amyloid plaques and tau protein tangles, with the objective of potentially alleviating or
delaying AD.
Development of Novel Spray-dried Microparticles to Treat Cystic Fibrosis:
A Tri-drug Approach
Authors: Kabra Vinayak D. , Lahoti Swaroop R. , Sugandhi Vrashabh V.
Published: November 2023

Background:

Cystic fibrosis is the predominant autosomal recessive disorder known to
reduce life expectancy. Research findings indicate that around 60 to 70% of adult individuals with
this condition carry infections of Pseudomonas aeruginosa.

Objective:

The ongoing research investigates the potential synergy of merging ivacaftor and ciprofloxacin
to address bacterial infections.

Methods:

The two drugs were spray-dried into microparticles, which were then coated with Lsalbutamol
and were to be delivered by a dry powder inhaler. Microparticles were generated by applying
the spray drying method, utilizing bovine serum albumin and L-leucine in their preparation.
Additionally, L-salbutamol was mixed and adsorbed onto the surface of the spray-dried microparticles,
and it acted as a bronchodilator.

Results:

The microparticles produced via spray drying exhibited a particle size measuring 1.6 ±
0.04 μm, along with a polydispersity ratio of 0.33. Their zeta potential measured -27.3 ± 1.1 mV,
while the mass median aerodynamic diameter of these microparticles was 3.74 ± 0.08 μm. SEM,
XRD, and FTIR studies confirmed the entrapment of ivacaftor and ciprofloxacin. The morphology
was observed by SEM and TEM scans. Antibacterial synergy was confirmed through the agar broth
and dilution method, and the formulation's safety was established based on the outcomes of the
MTT assay.

Conclusion:

Using spray-dried microparticles containing ciprofloxacin, ivacaftor, and L-salbutamol
presents a novel approach to the treatment of cystic fibrosis.
Diversidad de Orchidaceae en un área de la Sierra Madre Oriental en Tamaulipas, México
Authors: Baltazar Leal Samantha , Herrera Monsivais María Concepción , Solano Rodolfo
Published: November 2023

Antecedentes y Objetivos: La Sierra Madre Oriental alberga una alta diversidad florística, pero en su porción más septentrional ha sido pobremente explorada y carece de estudios que documenten la riqueza de la familia Orchidaceae en esta región. El objetivo de este trabajo fue contribuir al conocimiento de la diversidad de orquídeas en la porción septentrional de la Sierra Madre Oriental ubicada en Tamaulipas.
Métodos: Mediante trabajo de campo se realizó el inventario de orquídeas en las localidades Conrado Castillo, municipio Hidalgo, y Los San Pedros, municipio Güemez. A cada género registrado se le asignó su afinidad fitogeográfica. La riqueza orquideológica de Conrado Castillo y Los San Pedros fue comparada con otras 14 localidades del país ubicadas en la vertiente del Golfo de México y sureste de Texas, mediante el índice de Sørensen, para construir un dendrograma de áreas con el método UPGMA.
Resultados clave: En la zona de estudio se registraron 35 especies, 29 en Conrado Castillo y 18 en Los San Pedros; 12 taxones estuvieron presentes en ambas localidades. Bletia jucunda, Corallorhiza striata, Corallorhiza wisteriana, Deiregyne densiflora, Goodyera brachyceras, Goodyera oblongifolia, Malaxis abieticola, Malaxis brachyrrhyncha, Schiedeella transversalis, Sotoa confusa y Tamayorkis hintonii son nuevos registros para la flora de Tamaulipas. De las especies registradas, 86% son terrestres; el bosque de Pinus-Quercus registró la mayor riqueza de orquídeas (80%). La afinidad florística mejor representada fue la meridional (82% de los géneros), seguida por la asiática (14%) y boreal (4%). La orquideoflora de la zona estudiada es similar a la que se encuentra en localidades de Nuevo León y Texas.
Conclusiones: Aunque la zona de estudio se ubica en la región boreal de México, alberga una orquideoflora con afinidad tropical. Los 11 registros nuevos aquí reportados incrementan a 102 especies la riqueza de Orchidaceae para Tamaulipas.
Value of Electronic Health Records Measured Using Financial and Clinical Outcomes: Quantitative Study
Authors: Modi Shikha , Feldman Sue S , Berner Eta S , Schooley Benjamin , Johnston Allen
Published: November 2023

Background

The Health Information Technology for Economic and Clinical Health Act of 2009 was legislated to reduce health care costs, improve quality, and increase patient safety. Providers and organizations were incentivized to exhibit meaningful use of certified electronic health record (EHR) systems in order to achieve this objective. EHR adoption is an expensive investment, given the resources and capital that are invested. Due to the cost of the investment, a return on the EHR adoption investment is expected.

Objective

This study performed a value analysis of EHRs. The objective of this study was to investigate the relationship between EHR adoption levels and financial and clinical outcomes by combining both financial and clinical outcomes into one conceptual model.

Methods

We examined the multivariate relationships between different levels of EHR adoption and financial and clinical outcomes, along with the time variant control variables, using moderation analysis with a longitudinal fixed effects model. Since it is unknown as to when hospitals begin experiencing improvements in financial outcomes, additional analysis was conducted using a 1- or 2-year lag for profit margin ratios.

Results

A total of 5768 hospital-year observations were analyzed over the course of 4 years. According to the results of the moderation analysis, as the readmission rate increases by 1 unit, the effect of a 1-unit increase in EHR adoption level on the operating margin decreases by 5.38%. Hospitals with higher readmission payment adjustment factors have lower penalties.

Conclusions

This study fills the gap in the literature by evaluating individual relationships between EHR adoption levels and financial and clinical outcomes, in addition to evaluating the relationship between EHR adoption level and financial outcomes, with clinical outcomes as moderators. This study provided statistically significant evidence (P<.05), indicating that there is a relationship between EHR adoption level and operating margins when this relationship is moderated by readmission rates, meaning hospitals that have adopted EHRs could see a reduction in their readmission rates and an increase in operating margins. This finding could further be supported by evaluating more recent data to analyze whether hospitals increasing their level of EHR adoption would decrease readmission rates, resulting in an increase in operating margins. Hospitals would incur lower penalties as a result of improved readmission rates, which would contribute toward improved operating margins.
THE RELATIONSHIP ANALYSIS BETWEEN ENVIRONMENTAL PERFORMANCE AND ECONOMIC VALUE OF THE COMPANY
Authors: Petrović-Ranđelović Marija , Stevanović Tatjana , Kostić Zorana
Published: November 2023

The importance of environmental sustainability is becoming greater due to its contribution to greater value for customers and convergence of the circular economy and Industry 4.0, which can improve the efficiency of limited resource use. Based on the information from environmental accounting, managers can more effectively assess the economic impacts that corporate environmental performance generates on the company's operations. Environmental performance can be improved by developing new products and production processes in order to minimize the potential negative environmental impact. Many companies have introduced the practice of corporate self-regulation, which includes environmental management systems and reporting on the company's non-financial performance. The obtained results of the conducted empirical research could help managers  make optimal decisions at the right time, and perform effective monitoring and rank of environmental and economic business indicators during the time.
TRADITION AND CULTURE AS THE BASE FOR THE TOURISM PRODUCT: CASE OF UNESCO INTANGIBLE HERITAGE
Authors: Pantović Danijela , Cvijanović Drago , Cvijanović Gorica , Šobić Ljiljana
Published: November 2023

The traditional Serbian folk dance Kolo was included in the UNESCO Representative List of the Intangible Cultural Heritage of Humanity in 2017. Kolo is a communal folk dance that is performed at both public and private celebrations of the most significant occasions in people's lives and the lives of communities. Kolo is an important socially integrating component of Serbian cultural heritage. The paper investigates the potential of learning Serbian dance as part of the cultural tourism offer of different regions in Serbia. Data were obtained through a survey using the Likert scale and analysis using SmartPls software. The aim of this research is to examine the tradition of local tourism based on folklore culture with which tourists have cultural contact as well as the effect of culture and tradition on the intention and interest in folklore culture. The study reveals a high and statistically significant positive impact of motivation for travel, culture, tradition and interest in Serbian traditional dance - kolo.
Measured versus computed settlements of La Yesca Dam upon its construction
Authors: Romo Organista Miguel Pedro , Hermosillo Arteaga Armando Rafael , Márquez Quintos Erick , Magaña Del Toro Roberto , Sarmiento Solano Neftalí
Published: November 2023

The definition of rockfill-loading behaviour is one of the difficulties the dam engineer faces to properly model a rockfill dam’s behaviour upon their construction and hence reach confident results that lead to safe designs. Perhaps, the main reason why the stress-strain rockfill properties are difficult to obtain is the large size of the rockfill particles that usually exceed the capabilities of most existing geotechnical laboratories. Accordingly, field research was carried out to monitor the behaviour of several rockfill dams built in Mexico with several rosettes of pressure cells and of extensometers, placed at several elevations within the rockfill embankments as they were built. Therefore, it was possible to define the stress-strain characteristics of the rockfill when the monitoring results were coupled with giant odometer laboratory test results. On the basis of these results, a power law was found to be good enough to model the rockfill behaviour under increasing normal loading. To assess the confiability of the 3D finite differences-power law model, the stress-strain behaviour of La Yesca dam was calculated throughout its construction. This paper shows a comparison between the monitored settlements and those computed using the above mentioned power law included in a 3D finite differences model and clearly indicates that this analytical model reproduces quite well the measured settlements, which leads to the conclusion that the proposed modelling of La Yesca dam is adequate and, henceforth, this modelling can be applied confidently to design rockfill dams.
Adherence of Candida Species Isolated from Patients with Head and Neck Cancer Presented for Radiation Therapy and its Correlation with Hemogram
Authors: Babu Neethu , Saikumar Chitralekha , Raphael C. Jomon
Published: November 2023

The objective of the current study was to quantify the adherence property of Candida species causing infections in head and neck cancer patients on radiation therapy (RT) or chemoradiotherapy (CRT). Additionally, the study aimed to establish a correlation between adherence properties and patients’ hemograms. A prospective cohort study was done on head and neck cancer (HNC) patients with oropharyngeal candidiasis. All patients received radiation doses ranging from 60 to 70 Gy using Intensity Modulated Radiation Therapy. Inoperable patients received concurrent chemotherapy with cisplatin 40mg/m2 once weekly during the course of RT. Swabs were collected from patients with signs and symptoms of candidiasis and microbiological confirmation and speciation were done according to standard protocol. An in vitro adherence test was done. Hemogram of all the patients at the start of infection was compared with the adherence. Candidiasis was detected in 58(35.3%) out of a total of 164 patients (Age 36-85). Candida albicans was the most prevalent 39(67.2%) species isolated. C.albicans showed the highest adherence which was statistically significant. The hemogram at the start of treatment and with C. albicans infection showed a statistically significant decrease in the absolute lymphocyte count (p-value 0.0001), RBC count (p-value 0.004) and haemoglobin level (p-value 0.003). Less adherence was seen with non-albicans Candida infection when compared to C.albicans (Odds 0.894, 95% CI -0.818-0.977), significant at 5 % (0.013). C. albicans showed significant adherence, which indicates the severity of infection. The occurrence of oral candidiasis is strongly associated with low lymphocyte count and severity of mucositis. Absolute lymphocyte count needs to be monitored in HNC patients who are undergoing RT or CRT.
Comparison of Antimicrobial Effectiveness of Orange and Lime’s Extracts on Aeromonas sobria and Aeromonas hydrophila
Authors: Lubis Nenni Dwi Aprianti , Amelia Sri , Yusraini Era , Rahmi Zikrina , Balatif Ridwan
Published: November 2023

Aeromonas bacteria are often found in aquatic environments and can be isolated from various types of fish. Globally, the incidence of infection by Aeromonas reached 0.6–76 cases per 1 million people. Orange and lime are generally used as cooking spices to get rid of the fishy smell in fish, and also have antibacterial effects. The study compared the antibacterial effectiveness of lime and orange extracts on two Aeromonas species; A. sobria and A. hydrophila. Bacteria Aeromonas may emerge from fresh tuna bought in traditional markets. Lime and orange extracts were prepared using the maceration method using 96% methanol as solvent. The extract concentrations used were 6.25%, 12.5%, 25%, and 50%. Antimicrobial sensitivity test was carried out using the Kirby-Bauer method. The bacterial inhibition zone test revealed that the effectiveness of extracts on both oranges and limes was higher for the bacteria A. hydrophila compared to A. sobria. It is known from the average diameter of the inhibition zone, which is larger on A. hydrophila compared to A. sobria, except for the extract with a concentration of 6.25% orange and 50% lime. In a comparison between extracts, lime extract was found to be more effective as an antimicrobial than orange extract, except at a concentration of 6.5% in the bacterial test A. sobria and 50% concentration in the bacterial test A. hydrophila. In general, lime is more effective as an antimicrobial than orange.
Gut Microbial Profile Differences in Autoimmune Diseases
Authors: Alkhulaifi Manal M. , Selayem Shahad A. Bin , Alquwayzani Munirah A. , Alabdullatif Nujud A. , Menezes Godfred A.
Published: November 2023

The human gut microbiota has been widely studied due to the possibility of high-throughput sequencing. Humans are distinctly inhabited by normal flora and symbiotic microbial flora, with bacteria accounting for the vast bulk of the component microorganisms. These organisms can be found in a variety of locations throughout the body, including the oral cavity, vagina, skin and stomach. Microbe types and abundance vary in different organs of the same person, but they may also differ between persons. They are very important for human health and also affect the immune system by altering its metabolism and behavior. Conditions such as malnutrition, Crohn’s disease, inflammatory bowel disease and colon colitis, in addition to metabolic disorders including type II diabetes and obesity, have all been associated with the gut microbiota. Several studies in recent years have emphasized the relevance and involvement of commensal bacteria in the development of a variety of disorders, including autoimmune diseases. Autoimmune diseases, Such as Graves’ disease, systemic erythematosus lupus (SLE), and irritable bowel syndrome (IBS), are commonly known for their loss of self-tolerance, a hyperactive reaction against the body’s own tissue. Autoimmune diseases are triggered by the immune system targeting self-tissues, and their global frequency is estimated to be between 3 and 5%. This review reaffirms the links between autoimmune disorders and gut bacteria. The precise pathophysiology is unknown; however, environmental factors (such as lifestyle, diet, medications, and infections) and specific genetic conditions have been expected. The gut microbiota is important in autoimmunity because changes in microbial composition can trigger immunological tolerance loss.
Consumers’ attitude toward the source of biotechnology
Authors: Zhang Xumin , House Lisa , Karavolias Joanna , Gao Zhifeng , Briz Teresa , Haas Rainer
Published: November 2023

Existing research based on labels, risks and benefits, and cultural differences has focused on consumers’ preferences for genetically modified (GM) food products. Limited attention has been paid to the attitudes toward the source who developed the biotechnology. Because there may be trust issues associated with large multinational firms that are often involved in the development of biotechnology, it remains an unexplored question whether consumers consider who produces the technology when forming opinions about food produced with biotechnology. This study investigates consumers’ attitude toward the source of biotechnology using a choice experiment with GM oranges. The study involved participants from three major orange-consuming countries (United States, Germany, and Spain). Results reveal that participants from all three countries were less willing to pay for GM oranges when the technology originated from multinational agribusiness corporations, compared to public universities and small companies. Further examining the effect of consumers’ perceptions, we found consumers’ perception of corporate distrust and environmental concern negatively influence their attitude toward the source of biotechnology, but their technology acceptance positively affects the attitude. By understanding consumers’ attitudes about the source of biotechnology and factors that may improve the consumer reactions, communication and promotion of new biotechnology food products to improve acceptance from existing and potential consumers are discussed.
THE RELATIONSHIP BETWEEN SELF-CONTROL AND PREMARITAL SEXUAL BEHAVIOR AMONG BOARDING HOUSES AND NON-BOARDING HOUSES STUDENTS IN DKI JAKARTA
Authors: Damayanti Riblita , Irmayanti Eka Nia
Published: November 2023

This study aims to examine the relationship between self-control and premarital sexual behavior in boarding houses and non-boarding houses students in DKI Jakarta. The number of samples in this study were 260 students. This research sample uses a quantitative approach by using a self-control scale and a premarital sexual behavior scale. Data were analyzed using pearson correlation and comparing subjects based on residence using independent sample T-test. The results of the correlation between self-control and premarital sexual behavior show that there is a significant negative correlation between the two variables where if self-control is high then premarital sexual behavior is low, and vice versa if self-control is low then premarital sexual behavior will be high. Based on the comparative results of self-control and premarital sexual behavior in boarding houses and non-boarding houses students, it shows that non-boarding houses students have higher self-control than boarding houses students. While premarital sexual behavior in boarding houses students is higher than that of non-boarding houses students
The Making of the Liveable City: The Overlooked Aspects of Smart Cities Design
Authors: Hatem Faten Mostafa
Published: November 2023

This article examines the real potential of smart cities to offer a
better experience to residents as people with more than just basic
needs. This is done through a lens of design, urban encounters and
on-site sensations. The topic is presented and discussed in four main
themes; Facilitating the Making of Livable City and Quality Experience,
Mental Associations of the City, The Unique Intimacy of the Night
Experience, Emotional Responses: Safety, Stress and Discomfort, and the
Taste of the City: Character, Wayfinding and Monotony. This is done to
facilitate analysis and communication. Nevertheless, the topics
presented here should not be separated from one another. Various
qualitative methods were used in the analysis of the Milton Keynes case
study. This includes interviews, field observations and visual
comparisons with other cases, allowing for a deeper understanding of the
different capabilities of the different approaches. The results help to
further fill the knowledge gap in the literature on the overlooked
aspects of smart cities and provide better information for smart city
design.
Process development for laser powder bed fusion of GRCop-42 using a 515 nm laser source
Authors: Gruber Samira , Stepien Lukas , Gerdt Leonid , Lopez Elena , Kieser Jan , Brueckner Frank , Leyens Christoph , Bratt Craig
Published: November 2023

Copper is widely used in high heat flux and electrical applications because of its excellent electrical and thermal conductivity properties. Alloying elements such as chromium or nickel are added to strengthen the material, especially for higher temperatures. Cu4Cr2Nb, also known as GRCop-42, is a dispersion-strengthened copper-chromium-niobium alloy developed by NASA for high-temperature applications with high thermal and mechanical stresses such as rocket engines. Additive manufacturing (AM) enables applications with complex functionalized geometries and is particularly promising in the aerospace industry. In this contribution, a parametric study was performed for GRCop-42 and the AM process laser powder bed fusion (PBF-LB/M) using a green laser source for two-layer thicknesses of 30 and 60 μm. Density, electrical conductivity, hardness, microstructure, and static mechanical properties were analyzed. Various heat treatments ranging from 400 to 1000 °C and 30 min to 4 h were tested to increase the electrical conductivity and hardness. For both layer thicknesses, dense parameter sets could be obtained with resulting relative densities above 99.8%. Hardness and electrical conductivity could be tailored in the range of 103–219 HV2 and 24%–88% International Annealed Copper Standard (IACS) depending on the heat treatment. The highest ultimate tensile strength (UTS) obtained was 493 MPa. An aging temperature of 700 °C for 30 min showed the best combination of room temperature properties such as electrical conductivity of 83.76%IACS, UTS of 481 MPa, elongation at break (A) at 24%, and hardness of 125 HV2.
Fra verdidokumenter til verdier i praksis – en planlagt øvelse
Authors: Stakkeland Ragnhild , Tveter Kivle Benedicte
Published: November 2023

Innledning: I denne artikkelen vektlegger vi betydningen av planlagt øvelse i praktisering av vedtatte verdier på arbeidsplassen. Mange helsetjenester har vedtatte verdier som ideelt sett skal påvirke utøvelsen av tjenesten. Skal verdiene påvirke praksis, trengs en bevissthet omkring hvordan bevegelsen fra vedtatte verdier til verdipraksisen styres og ledes. En utbredt tilnærming til praktisering av verdier handler om refleksjon over praksis. Vi hevder i artikkelen at refleksjon over praksis ikke er tilstrekkelig, og vi utforsker potensialet som ligger i å ta i bruk etablerte arenaer på arbeidsplassen for felles øvelse i å praktisere bestemte vedtatte verdier.
Metode: En kvalitativ intervjustudie av fem ledere ved et norsk kompetansesenter der ledere og ansatte har gjennomgått en planlagt og vellykket verdiprosess.
Funn: En deltagende prosess for å etablere felles verdier er ikke i seg selv en garantist for at vedtatte verdier blir praktisert i yrkesutøvelsen. Vi fant heller at planlagte verdipraksiser kunne bidra til å forsterke ønskede verdier i praksis internt og eksternt i tjenesten. Betydningen av felles verdipraksiser ble tydelig illustrert da en kollektiv verdipraksis, et såkalt glødebarometer, ble innført og utviklet i kompetansesenteret som en intern praktisering av verdien anerkjennelse. Praksisen hadde innvirkning på ansattes og lederes bevissthet rundt hvordan anerkjennelse kom til uttrykk i praksis. Den kollektive øvelsen i å utøve anerkjennelse internt gav praktisk kompetanse i å utøve verdien også eksternt.
Konklusjon: Ved hjelp av institusjonell handlingsteori forstår vi planlagte, interne (ut)øvelser av verdier som en egnet fremgangsmåte for å påvirke praktiseringen av vedtatte verdier. Basert på erfaringer fra en verdiprosess av beste praksis i et norsk offentlig kompetansesenter i psykisk helse utleder vi en hypotese om at vedtatte verdier påvirker praksis gjennom interne felles verdipraksiser. Hypotesen må prøves videre i ulike kontekster.