bluuebunny/crossref_metadata_2025 huggingface dataset:
Physicochemical Characteristic of Sago Hampas and Sago Wastewater in Luwu Regency
Authors: Nururrahmah Hammado , Budiyono  , Sudarno Utomo
Published: December 2018

A study was carried out to determine the physicochemical characteristics of sago hampas and sago wastewater from sago processing mill in Luwu Regency. The sago hampas was used is the residue of sago starch filtration of unrefined raw fiber. The sago wastewater was taken from processing mill are discharged into river. The points of sago wastewater sampling were undertaken in three different points, namely first wastewater (A1), the last wastewater (A2), and water that has been discharged into the river (A3). The sago hampas and sago wastewater processing mill was obtained by Spectrofotometric, Atomic Adsorption Spectroscopy, and analytical methods. The sago hampas content was found at C-Organic 33.01%; N-total 1.66%; C/N ratio 20; P2O5 0.04%, and minerals which are Calsium 27716 ppm, Magnesium 4247 ppm, and Sulfur 743 ppm. COD concentration sago from wastewater was found at A3 point which is 177.3985 mg/l; N-total 0.1%; Phospor 0.01 ppm; Kalium 10.46 ppm; Magnesium 5.84 ppm; and Calsium 0.62 ppm. The high content of organic materials and minerals in sago hampas and sago wastewater needs to be processed before discharging it into the river. The results of this study indicate that sago waste can be used as a feedstock biogas production.
Developing Indicators to Implementing Green Material Management in Construction Industry: A Literature Review
Authors: Nur Farida , Handayani Naniek U. , Wibowo Mochamad A.
Published: December 2018

Material waste is one of waste that has been identified as a significant problem of the construction industry and also has a negative impact on the environment. Therefore, it is necessary to find the way to increase the efficiency of material used and minimize environmental impact. Green material management is one of the concepts that are a part of green supply chain management. This concept is commonly used in manufacture industry. The purpose of this study is to adopt the concept of green material management in manufacture industry to apply for the construction industry. A literature review was conducted to learn from previous research about the implementation of green material management in manufacture and construction industry. Some previous research has been figured out the framework of green material management in the construction industry, but the result are still limited to identify the concepts, dimensions, and elements. Indicators are needed so the concept can be applied appropriately and clearly. The result of this study is a framework of green material management concept in the construction industry that consists of five dimensions, 16 elements, and 20 indicators.
Does CSR Disclosure Solve Social Conflicts Between Companies and Community? An Empirical Evidence
Authors: Anis Chariri
Published: December 2018

This study aimed to investigate whether CSR programs can be used by companies to solve social conflicts between companies and communities. We conducted empirical tests using data gathered from the society living in the areas closed to mining companies (Cilegon and Cilacap, Indonesia) and company managers-who responded to our survey. The findings showed that CSR disclosures have not been able to solve social conflicts between companies and the society. This study indicated that there are differences in the views of companies and communities on the importance of CSR programs. Indeed, CSR programs which are seen as important by the community are not considered as essential by the companies. This implies that the community is not seen by the companies as an important and powerful stakeholder. Consequently, social conflicts will continue to occur as long as the companies do not pay attention to the public interests.
Agropolitan Development in Merapi Disaster Affected Areas
Authors: Sartono  , Iwan Hermawan , Alfi Maghfuriyah
Published: December 2018

Magelang Regency is a strategic city in Central Java. The regency has famous tourist destination objects such as Borobudur Temple, besides the fertile climate and soil conditions are an invaluable asset to support agribusiness development. The position of the boundary line between the city area roomates becomes the product market and the village that the production buffer zone may be developed into a competitive Agropolitan region. The obstacles that arise are Magelang Regency is the affected area of Mount Merapi activity, in addition to causing fertility in agricultural land, and the tectonic earthquake eruption become obstacles to the development of potential areas of Merapi disaster, due to the high of physical hazards such as infrastructure damage. The direction of this paper is to look for potential Agropolitan location references with the guarantee of infrastructure service support, the disaster zone equality into a node that connects the area of agribusiness-producing regions in all regency in Magelang regency. The LQ and KS methods are used to bridge the analysis studies in this paper.
Design of Family and Child Welfare Policy in Indonesia
Authors: hammad Adnan
Published: December 2018

Family is the basis of public welfare. Family welfare determine the children development. Indonesia government ensure family and child welfare of their citizen by applying Child Rights Convention and strengthen some policies. Indonesia government, through Ministry of Social, also arranged PKSA/ Children Welfare Program. This program classify vulnerable child into five cluster, and reach them by three ways: integrated cash aid, social workers, and access to social services. This program targeted no less than 4.3 million children in all region. Though this program were succesfully implemented, but still needed some improvement, such as involvement of local government, recruitment of social workers, and more establishment of LKSA with good facilities and services. PKSA should also be financially sustainable that can reach more children from many families with its whole services.
The Border Area Conflict Impact on Government Responsiveness Relating on Public Service
Authors: Eny Boedi Orbawati , Sri Suwitri , Yuwanto
Published: December 2018

Responsiveness or response are the desire and the will of the bureaucracy in the expectations, desires and aspirations and demands of the community services provided quickly and responsively. The responsiveness of government bureaucracy needs to be done across Government jurisdictions begin from the Central Government to the border region. However, the occurrence of conflict affirmation borders of Magelang regencies and cities affected the responsiveness of regional pemerinrah in the service of public administration services in particular resistance. This research aims to describe and determine the factors affecting the responsiveness of local governments in implementing public service in conflict areas and County boundary affirmation in Magelang city . The methods used in this research is a mix of qualitative and quantitative approaches are converging. Data collection is done by survey, interview and documentation. Qualitative data analysis done through interactive model with the validity methodology of the analysis focuses on the triangulation, with rolling according to needs also use techniques of the other validity. The research's results show that the local government County and Magelang city has not been responsive in public services on the territory of the conflict area limits the visible affirmations of public service obstrction of the administration of land in the region. Yet the responsiveness of the local government in the public service is affected by the problem complexity, Government regulatory authorities and the County and Magelang City, leadership of public officials who are not able to listen to the grievances of the public and the haven't priority of the broader public interest in making the corresponding decisions of public service in the area of the disputed boundary area.
Evaluation Study of Human Development Index (Policy Learned from Salatiga City and Semarang City)
Authors: Ahmad Taufiq , Edi Santoso
Published: December 2018

The objective of the research is to analyze the success story of the Salatiga City and Semarang City in the best three achievements and position in Human Development Index in the Central Java Province 2013-2015, what kinds of policy learned can be taken. The research uses qualitative model with several informants as sources of primary data. The data is taken by interviewing with some informants, such as: Local Government Health Service of Salatiga City and Semarang City, Local Government Educational Service of Salatiga City and Semarang City, Regional body for planning and development (Bappeda) of Salatiga City and Semarang City. Triangulation method is the best way to eliminate the fact contruction differences in the context of a certain study when collecting the data about the events and relationships of the various views. Through this technique the researchers also compared the findings with a variety of sources. The study found, firstly, in the health sector, Salatiga City have mainly program, that is improve and practice OSOC (One Student One Client) program, the program focuses in pregnant women with highly risk, OSOC program involve the local government, the obsgins doctor and student of university (especially health academy student), after recoding the pregnant women with highly risk and then become the student client. Meanwhile Semarang City improves and practice EMAS (Emerging Maternal and Neonatal Survival) program based on cooperation with USAID. As we know that the maternal and neonatal mortality is important aspect of Human Development Index. Secondly: in education sector, Salatiga City and Semarang City improve and practice Local Student Operational Aid (BOSDA) and Poor Student Aid for basic and junior school student, that program can increase the educational partisipation rate.
Green Banking and Infrastructure Project Financing for Sustainable Development
Authors: Arinal Fashli , Herdis Herdiansyah , Putri A Saragi
Published: December 2018

Indonesia already has policies that pay attention to environmental aspects so that the development can keep running by maintaining the natural conditions. One of the policies that have been made is green banking. The green banking policy requires the support of stakeholders who have a role as an enforcer. This study uses a quantitative approach to measure the implementation of funds used by banks in the financing of industrial projects. The database is based on the Sustainable Equity and Responsible Investment (SRI) index -KEHATI, one of the indices that the indicator of stock price movement in Indonesia Stock Exchange (BEI), but focus on banking data practicing green banking system. The result of this study shows that the bank has a responsibility to the environmental risks of the project to be run by the company where the investment funds or lending of the bank. The green banking policy requires the support of stakeholders who have a role as an enforcer. Stakeholders in green banking are groups of people or individuals who have an essential part to achieve goals, and Sustainable development can be realized well if this policy is implemented, not just a formal requirement in following the current international trend.
Income Inequality in Indonesia: Panel Data of 34 Provinces 2014-2016
Authors: Mohammad Rofiuddin , Firmansyah
Published: December 2018

Income inequality is the difference in the ability of people to have goods or services, and more broadly, it is the problem of community welfare. Income inequality can be measured at regional, national and global level. Income inequality in Indonesia,, which representing by Gini index, is still relatively high, even though the number tends to decline. The high level of income inequality is influenced by various factors. This study aims to analyze the influence of economic growth, population and provincial minimum wage toward income inequality in Indonesia. By applying a fixed-effect of panel data regression model of the 34 provinces along 2014-2016, the study finds that economic growth and population do not affect the income inequality, while provincial minimum wage has the negative effect.
Globalization and Expectation of The Country's Prosperity
Authors: Hikmah Nuraini
Published: December 2018

Globalization is technological advancement and openness of information presented, and offered to be followed by other Nations as an agreement and shared guidelines for Nations around the world. The process of globalization can be characterized by the role of the market is so big and the acquisition of investment and production by transnational corporations. Globalization impact on injustice and inequality for the developing countries. The approach in the village development in the global era is that the village became prosperous can be initiated through refining global element into the values of the local countryside. This research aim to observe strengthening strategy of village development as economy, social, and cultural pillars in the globalization era. This method applies qualitative with secondary data and conceptual analysis. This finding is the villahe become the arising and development places of the local wisdom, in order those are needed managerial strengthening strategy through guidelines of village management. The village isn't passive object should be following globalization way but it should fulfill globaliztaion chance by wisdom value owned in order it will be not only a globalization but also how the village determined unit entity into applying globalization without eliminating local wisdom as a supporting factor.
The Craft of Relief Carving Art and Its Impact on The 21st Century Jepara Craftsmen's Economic Life
Authors: Alamsyah  , Arido Laksono
Published: December 2018

The article on “The Craft of Relief Carving Relief Art and Its Impact on the 21st Century Jepara Craftsmen's Economic Life” describes the craft of relief carving which has an impact on the economic life of the Jepara craftsmen. The existence of Jepara relief art had been proven historiographical. Relief art has existed since the time of Queen Kalinyamat in the 16th century. The artifacts of relief carving art in Queen Kalinyamat's period are found in Mantingan Mosque in Jepara. The relief of carving craft gets its influences from various fields, including the influence of religion, local culture, Chinese culture, and others. In the 1990s to the beginning of the 21st century, relief craft increasingly innovated by enriching motifs and decorative reliefs in the form of flora, fauna and other motifs. Through various motives in the relief craft, the craftsmen get economic impact in the form of job sustainability.
Relationship between Company Financial Performance, Characteristic and Environmental Disclosure of ASX Listed Companies
Authors: Indah Fajarini Sri Wahyuningrum , Mochamad Arief Budihardjo
Published: December 2018

The study expects to find positive relations between company financial performance, company characteristics, auditing firm, and the extent of company environmental disclosure. The sample data used in this study is 200 largest Australian listed companies (ASX) in 2014. In order to explain the corporate social responsibility practices in Australian companies, this study used stakeholder and legitimacy theories. The measurement of company environmental disclosure in this study involves nine indicators of environmental disclosure index based on Environmental Social and Governance (ESG). More specifically, the statistical analysis indicates that earnings per share, return on equity, type of company, size of company, age of company, and auditing firm positively influence the company environmental disclosure. On the other hand, the results showed that return on assets has no relationship with company environmental disclosure. Overall, this study has added some information about corporate social disclosure studies focused on environmental disclosure of largest Australian companies.
Social Construction of “Fisherman”: Fisherman is Always Man, Women Loss Their Privileges
Authors: Sigit Andrianto
Published: December 2018

Several areas in Indonesia, including in Purworejo villages, Demak regency of Central Java, women went to sea to catch fish. Unfortunately, there are no guarantee of safety for women. They do not get any insurance from the government, because they dont have “Kartu Nelayan” (card for fishers). Although the government already has a protection program for fishers, women are always left out from this program. This study uses Phenomenology to describe how ideology is maintained in the society. This study found that the discourse of fisherman continues to be maintained, even unconsciously, by women themselves in their struggle. The social construction or the ideology about fisherman, that fisherman always a man, put women on the second class. Even though they go to sea, with the same workload and risk, they are only considered just to “help” their husband’s economy. This study argues, to change this situation, it is required to change the social order fundamentally.
The influence of technology determinism in forming criminal act of legislation
Authors: Raharjo Agus , Saefudin Yusuf , Fidiyani Rini
Published: December 2018

Technology has entered the human physical and spiritual existence. Technology is the reflection of the human soul in nature, it is the materialization of ideas in the human brain itself. Humans are increasingly fragmented and machines are increasingly dominant in human life, which causes problems in various fields, one of the fields is a law on the formulation of criminal acts in various legislation. To clarify this problem, normative research methods are used with a focus on comparative legislation. Laws of increasingly technological and technological nature adopt legal features in the work of science and technology. Lawmakers make rules that reflect technological determinism as well as against it. They glorify technology as well as make technology as one of the factors of criminal liability. This seems in the comparison between general criminal law legislation that originates from the Criminal Code with other laws and regulations that contain technological elements. Technology-based criminal penalties in general criminal law are unknown, and this only arises after the technology is used to commit criminal acts, such as in criminal acts of decency, humiliation, defamation, and crime dimension technology. This rationale needs to be deciphered considering the lawmakers is poor to give an explanation.
The Contact Simulation Comparison of UHMWPE to the Crosslink Intensity Effect
Authors: Al Hakim Reza Azizul Nasa , Arrohman Sigit , Saputra Eko , Anwar Iwan Budi , Jamari J , Ismail Rifky , Bayuseno Athanasius P. , Tauviqirrahman Mohammad
Published: December 2018

Ultra High Molecular Weight Polyethylene called UHMWPE is a unique polymer material that has excellent physical and mechanical properties. UHMWPE material is frequently used in prosthesis. One example of UHMWPE uses in prosthesis is acetabular liner which is one component for Total Hip Joint Replacement (THR) and can also be found for bearing surfaces on the knee, ankle, shoulder, and connective tissue of the joint. UHMWPE material is made by compression molding process. However, UHMWPE wear often causes the failure of artificial hip joints. Therefore, a treatment to reduce the crosslink method is performed. The purpose of this study was to determine the crosslink effect in UHMWPE material. The method used for this analysis is ABAQUS 6-13 software. On bipolar model, the 3000 N load is applied in the FEM model. The crosslink dose used in this analysis was 50kgy, 75kgy, and 100kgy. The results obtained are that UHMWPE that has received by gamma irradiation treatment can receive a smaller stress distribution. The results of the simulation for UHMWPE without irradiation produced 0.759 stress distributions; 50kgy crosslink dose has 0.666 stress distributions; 75kgy crosslink dose has 0.662 stress distributions; and 100kgy crosslink dose has 0.660 stress distributions. This result proved that UHMWPE which has received crosslink can receive a better stress distribution. For the result crosslink with 100kgy dose received the best number of stress distributionss.
The dynamics change of fishpond land into settlement the east coast of Surabaya 2004-2017
Authors: Chairani Chahya , Saraswati Ratna , Ash Shidiq Iqbal Putut
Published: December 2018

Surabaya rapidly developed to the east region which grew the formal/non-formal settlement in Pamurbaya. This area is dominated by fishpond that is converted into settlement area. This research aims to observe the dynamic change of fishpond which is already converted into settlement area in the east coast of Surabaya, during 2004-2017. This research applies landsat image 7 ETM+ and landsat 8 OLI with overlay method which is analyzed descriptively. During 2004-2017, the settlement area had been developing for 218,296 Ha or 88% and during the same years, the fishpond had been reducing for 531,639 Ha or 24%, this reduction can change into mangrove or settlement area. During 13 years, the change of fishpond into settlement area is 15%. The research area which experienced the change is the fishpond of Kejawan Putih (24%), Medokan Ayu area (17%), and Keputih area (16%).
Android Based Self-Control Management System for Diabetes Mellitus
Authors: Nawangnugraeni Devi Astri , Isnanto R. Rizal , Nurhayati Oky Dwi
Published: December 2018

One of the biggest cause of death is Diabetes Mellitus caused by a lack of public understanding of the symptoms of the disease, so that the diagnosis of the disease is not done as early as possible. This paper presents the research and the development of an Android based self-control management expert system for Diabetes Mellitus patients. This expert system purposed to diagnose Diabetes Mellitus disease based on symptoms experienced and to manage the dietary pattern in patients. The method used to develop expert system is forward chaining method. Implementation of the forward chaining method begins with gathering information then applying reasoning as a determinant of diagnosis conclusions using rule based If-Then. The development result is an expert system that can be used to diagnose Diabetes Mellitus and can be used to determine the dietary pattern in patients who are implemented on Android based mobile devices. This system shows more specific results in determining the diagnosis of the disease based on 4 types of Diabetes Mellitus. In addition, more specific in determining dietary pattern such as showing the number of calories, food levels and variations of food that can be consumed by patients.
The Development of IT- Based Human Resources in Universitas Diponegoro
Authors: Dwimawanti Ida Hayu , Setianingsih Endang Larasati
Published: December 2018

Universitas Diponegoro (Undip) is a legal entity State University. Therefore, Undip is required to improve the quality of service. Human resources are the important aspect in improving services in Undip. The development of human resources in Undip is necessary; in the form of learning task, research and dedication, training, comparative study, professorships program, awards, coaching and career development. In this modern world, one aspect that needs to be considered is the ability of human resources in using IT. For example, Undip has to make sure that lecturers are required and able to write published scientific journals online. This research concluded that the success of human resource development in Undip depends on th Rector, employee commitment in the field of human resources of Undip, and the role of the Institute for Research and Community Service (LPPM) in encouraging and monitoring the implementation of research, dedication, and training.
Language Choice and Attitude of Maternal Communities in Semarang
Authors: Suharyo Suharyo , Subiantoro Subiantoro
Published: December 2018

This research focuses to describe the language choice and attitude of maternal communities in Semarang. To prove it, this research used 40 samples which are selected randomly. The data is collected through questionnaire, observation, and interview. The result showed that (a) the language choice and attitude of maternal communities is 5% of them use Indonesian when speak to their husband, 45% use Javanese and 50% use mixed language; (b) when they communicate with their children, 12,50% of them use Indonesian and Javanese and the 75% use mixed language; (c) they still expect Javanese subject to be well-taught at schools and homes (87,50%) and at home only (12,50%); (d) the Javanese language skill of the respondents is 12,50% very good, 67,50% good, and 20% less than good; and (e) the language attitude of the community reflects positive attitude 80% and negative attitude 20%.
Imagerie photoacoustique biomédicale
Authors: Vilov Sergey , Chaigne Thomas , Arnal Bastien , Bossy Emmanuel
Published: December 2018

Depuis le début des années 2000, l’imagerie photoacoustique connait un formidable essor en tant que technique d’imagerie optique biomédicale. Cet essor, qui se traduit à la fois par les nombreuses recherches menées par un nombre d’équipes de plus en plus important dans le monde et par les multiples applications qui en découlent, est lié aux performances uniques de cette modalité d’imagerie optique en termes de résolution et de contraste.
Schweigepflicht: Worauf Heilpraktiker achten sollten
Authors: Gosemann Laura
Published: December 2018

Heilpraktiker und Ärzte unterliegen der Schweigepflicht, jedoch auf Grundlage unterschiedlicher Gesetze: der Heilpraktiker gemäβ BGB und der Arzt gemäβ dem StGB. Das Patientengeheimnis gilt auch gegenüber dem Finanzamt. Im Gegensatz zum Arzt hat der Heilpraktiker kein Zeugnisverweigerungsrecht.
Ich sehe… was?
Authors: Herzog Michael , Sengebusch Jürgen
Published: December 2018

Diese Hautreaktionen treten meist schnell und heftig auf, und zwar aufgrund der verschiedensten Ursachen. Sie können sehr unterschiedlich und teilweise bedrohlich verlaufen. Es ist wichtig, den Hergang einschätzen zu können, um angemessen zu handeln.
PRÜFUNGSTHEMA: Erkrankungen im Mundraum
Authors: Schmid Eva C.
Published: December 2018

In dieser Ausgabe beschäftigen sich alle Prüfungsfragen mit Erkrankungen des Mundraums.
„Beip die Zähne zusammen!”
Authors: Casagrande Christina
Published: December 2018

Wie das Gebiss – vor allem von Kindern – beeinflusst wird und wie das in der Behandlung berücksichtigt werden kann. Die DHZ-Kolumne von Christina Casagrande.
Arzneimittelzulassung von Radiopharmaka im klinischen Rahmen
Authors: Schildan Andreas , Hirschfeld Jürgen , Patt Marianne , Sabri Osama
Published: December 2018

Grundlage für das Inverkehrbringen von Radiopharmaka ist die arzneimittelrechtliche Zulassung des betreffenden Arzneimittels. Bei der Arzneimittelmittelzulassung handelt es sich um eine behördliche Genehmigung, deren Zweck die Gefahrenabwehr durch unsichere oder unwirksame Arzneimittel ist und die nur für genau bezeichnete Indikationen gilt, bei denen das positive Nutzen-Risiko-Verhältnis des Arzneimittels erwiesen ist.

Neben rein nationalen Zulassungsverfahren existieren auch verschiedene Zulassungsverfahren auf europäischer Ebene, die zur Verkehrsfähigkeit der Arzneimittel in einem, mehreren oder allen Mitgliedstaaten der EU bzw. des EWR führen. Die erteilten Zulassungen gelten nicht unbegrenzt, sondern unterliegen z. B. der Pflicht zur Verlängerung durch den Genehmigungsinhaber. Änderungen in Qualität, Wirksamkeit und Unbedenklichkeit des Arzneimittels bedingen eine fortwährende Pflege der Antragsunterlagen im Rahmen von Änderungsanzeigen, die bestimmten formalen und inhaltlichen Voraussetzungen genügen müssen. Sind diese und andere Voraussetzungen nicht erfüllt oder treten Fristversäumnisse auf, kann eine Zulassung auch erlöschen.
Alles im Lot?
Authors: Strzemsky Simon
Published: December 2018

Das CMS umfasst den Kopf, Unterkiefer und alle Strukturen, die auf diesen Komplex einwirken. Treten in auf- oder absteigenden Verkettungen myofunktionelle Störungen auf, kann es zur CMD mit Symptomen im ganzen Organismus kommen. Mithilfe verschiedener Tests lässt sich ermitteln, welche Strukturen des CMS ursächlich beteiligt sind.
Prevalence of Sonographic Markers of Placenta Accreta Spectrum in Low-Risk Pregnancies
Authors: Philips Jennifer , Gurganus Margot , DeShields Sarah , Cunningham Tina , Sinkovskaya Elena , Kanaan Camille , Porche Lea , Abuhamad Alfred
Published: December 2018

Objective This study was aimed to evaluate the prevalence of sonographic markers for placenta accreta spectrum (PAS) in pregnancies at low-risk for PAS.

Study Design Pregnant women at low-risk for PAS presenting for routine second trimester ultrasound who enrolled in the study were evaluated prospectively for sonographic markers of PAS during two ultrasounds at 18 to 24 and 28 to 34 weeks. Frequencies of PAS markers were compared between the second and third trimester and between those with and without prior cesarean deliveries (CD).

Results Overall, 174 women were included. Several markers were seen frequently in the second trimester: vascular cervical invasion (57%), lacunae (46%), subplacental hypervascularity (37%), and irregularity of the posterior bladder wall (37%). Other markers were seen infrequently or not at all: loss of the retroplacental clear zone, uterovesical interface < 1 mm, bridging vessels, placental bulge or focal exophytic mass. Frequencies of markers did not differ between women with and without prior CD. Lacunae were larger and more numerous in the third trimester. Two or more PAS markers were observed in 98% of second trimester ultrasounds.

Conclusion Several PAS sonographic markers occur commonly in low-risk pregnancies. In the absence of risk factors, the independent predictive value of these markers is questionable.
Muscle-Specific Kinase Autoimmune Myasthenia Gravis: Report of a Pediatric Case and Literature Review
Authors: Benrhouma Hanene , Klaa Hedia , Ben Aoun Rania , Rouissi Aida , Ben Ahmed Melika , Kraoua Ichraf , Ben Youssef-Turki Ilhem , Ben Younes Thouraya
Published: December 2018

Myasthenia gravis (MG) with antibodies to the muscle-specific tyrosine kinase (MuSK-MG) receptor is a rare entity. It represents 5 to 8% of all MG patients. Few pediatric cases were reported. Clinical presentation is often atypical. It is characterized by predominant involvement of cranial, bulbar, and axial muscles and early respiratory crises. Myokymia and fasciculation are suggestive of MuSK-MG. The clinical course of patients with MuSK-MG is worse than other types of MG. Responses to standard therapies are variable. We report clinical, neurophysiological, serological, and outcome profile of a Tunisian child with MuSK-MG.
Health Care Professionals' Perceptions about Sensory-Based Interventions in the NICU
Authors: Pineda Roberta , Roussin Jessica , Heiny Elizabeth , Smith Joan
Published: December 2018

Objective The main objective of this article is to define perceptions of health care professionals regarding current use of sensory-based interventions in the neonatal intensive care unit (NICU).

Study Design A multidisciplinary group of NICU health care professionals (n = 108) defined the types of sensory-based interventions used in their NICU, the postmenstrual age (PMA) sensory-based interventions are administered, conditions under which sensory-based interventions are used, and personnel who administer sensory-based interventions.

Results The most commonly reported tactile intervention was infant holding (88% of respondents), the most common auditory intervention was recorded music/singing (69% of respondents), the most common kinesthetic intervention was occupational and physical therapy (85% of respondents), and the most common vestibular intervention was infant swings (86% of respondents). Tactile interventions were initiated most often at 24 to 26 weeks PMA (74% of respondents), auditory interventions at 30 to 32 weeks (60% of respondents), kinesthetic interventions at 30 to 32 weeks (76% of respondents), vestibular interventions at 33 to 34 weeks (86% of respondents), and visual interventions at 32 to 36 weeks (72% of respondents). Conditions under which sensory-based interventions were administered, and personnel who provided them, varied across settings.

Conclusion Varied use of sensory-based interventions in the NICU were reported. While this study was limited by biased sampling and the identification of health care professionals' perceptions but not real-world practice, this information can be used to build a comprehensive approach to positive sensory exposures in the NICU.
Variation in Gastrostomy Tube Placement in Premature Infants in the United States
Authors: Greene Nathaniel H. , Greenberg Rachel G. , O'Brien Sean M. , Kemper Alex R. , Miranda Marie Lynn , Clark Reese H. , Smith P. Brian
Published: December 2018

Objective To describe the variation in surgical gastrostomy tube (SGT) placement in premature infants among neonatal intensive care units (NICUs) in the United States.

Study Design We identified 8,781 premature infants discharged from 114 NICUs in the Pediatrix Medical Group from 2010 to 2012. The outcome of interest was SGT placement prior to discharge home from an NICU. Unadjusted proportions and adjusted risk estimates were calculated to quantify variation observed among individual NICUs.

Results SGT placement occurred in 360 of 8,781 (4.1%) of infants. Across NICUs, any gastrostomy tube placement ranged from none in 45 NICUs up to 19.6%. Adjusted risk estimates for factors associated with SGT placement included gestational age at birth (odds ratio [OR]: 0.7/week, 95% confidence interval[CI]: [0.65, 0.75]), small for gestational age status (OR: 2.78 [2.09, 3.71]), administration of antenatal steroids (OR: 0.69 [0.52, 0.92]), Hispanic ethnicity (OR: 0.54 [0.37, 0.78]), and higher 5-minute Apgar scores (7–10, OR: 0.54 [0.37, 0.79]).

Conclusion Individual NICU center has a strong clinical effect on the probability of SGT placement relative to other medical factors. Future work is needed to understand the cause of this variation and the degree to which it represents over or under use of gastrostomy tubes.
Histological and morphological studies of cardiac cells in response to aerobic exercise and rosemary extract in rat model of aging
Authors: Ababzadeh Shima , Iravani Amir , Fallahian Faranak , Aghamiri Seyed
Published: December 2018

Objective The average age of the world population is growing increasingly. Since aging is the biggest risk factor for cardiac diseases, the incidence of these types of disease will increase significantly in the near future. However, their occurrence may be prevented by some factors, such as the practice of aerobic exercise and the use of herbal medicine.

Materials and methods Thirty male Wistar rats, at 18 months old each, were divided into 5 groups (n = 6): control (NO), gavage (GO), exercised (EO), extract-fed (EXO), and exercised and extract-fed (EEO). The animals of the GO group received distilled water and were put on a silent electric running machine. The animals of the EO and EEO groups were assigned to a treadmill training protocol at low and moderate intensities for 1 hour/day, 5 days/week for 12 weeks. The animals of the EXO and EEO groups were treated with rosemary (Rosmarinus officinalis) extract for 12 weeks. At the end of the experiment, the hearts of the rats were collected and submitted to hematoxylin and eosin and Mallory trichrome staining. Images of these stained samples were captured, and a morphometric analysis of the cardiac tissue was performed.

Results The rats in the EO, EXO and EEO groups showed a reduction in the intercellular space when compared with those of the NO and GO groups. The rats in the EO and EEO groups showed an increase in the clarification of the intercalated discs and in the width of the cardiomyocytes, when compared with those in the other groups. The nuclei of the heart cells of the animals in the EXO group were seen as more euchromatic than others.

Conclusion Aerobic exercise causes changes in the cardiac muscles of rats and confirms the capacity of the fibers to adapt to the requirements of the proposed aerobic exercise. The antioxidants found in rosemary extract improve cell activity to achieve a better performance. However, applying these two factors simultaneously indicates the reduction of their positive influences.
Dravet Syndrome and Psychiatric Comorbidity
Authors: van Gemert Lisette , Gunning W.
Published: December 2018

This is a review of the prevalence of psychiatric comorbidity in patients with Dravet syndrome (DS) and the predictors of psychiatric comorbidity. Symptoms of attention-deficit hyperactivity disorder are most frequently reported in children with DS. Autistic features and “other behavior problems” are also found in a considerable proportion of children. No consistent relationship has been found with intellectual disability level, age of onset of seizures, delay in diagnosis, and seizure frequency. A major limitation of the literature is that formal psychiatric assessment has rarely been applied.
Perturbative measurement of magnetoresistance
Authors: Oliveira A. B. , de Melo A. C. C. , da Costa R. B. , Costa N. P. , Azevedo A. , Chesman C.
Published: December 2018

In this paper, we report the development of a novel technique in which the magnetoresistance of nanostructures is perturbatively measured by transversally modulating the DC magnetic field. It measures the electrical transport counterpart of the transverse magnetic AC-susceptibility. The technique was developed in a conventional four-probe configuration in which a small DC current flows through the sample and a small transverse AC-field perturbates the equilibrium position of the sample magnetization. Lock-in detection, in-phase with the AC-perturbation, is used to measure the voltage signal between the two inner electrodes of the four-probe station. We successfully demonstrated that this signal is proportional to the product of the first derivative of sample resistance with respect to the equilibrium position of the magnetization times the second derivative of the energy with respect to the equilibrium position of the magnetization. These dependences add new features to the technique investigated here that were not captured by the investigations previously reported on the same subject. To show the effective use of the technique, we discuss its application in measuring magnetic properties of thin magnetic films in the non-saturated regime.
Contributed Review: A review of compact interferometers
Authors: Watchi Jennifer , Cooper Sam , Ding Binlei , Mow-Lowry Conor M. , Collette Christophe
Published: December 2018

Compact interferometers, called phasemeters, make it possible to operate over a large range while ensuring a high resolution. Such performance is required for the stabilization of large instruments dedicated to experimental physics such as gravitational wave detectors. This paper aims at presenting the working principle of the different types of phasemeters developed in the literature. These devices can be classified into two categories: homodyne and heterodyne interferometers. Improvement of resolution and accuracy has been studied for both devices. Resolution is related to the noise sources that are added to the signal. Accuracy corresponds to distortion of the phase measured with respect to the real phase, called non-linearity. The solutions proposed to improve the device resolution and accuracy are discussed based on a comparison of the reached resolutions and of the residual non-linearities.
Tutorial: The systematics of ion beam sputtering for deposition of thin films with tailored properties
Authors: Bundesmann Carsten , Neumann Horst
Published: December 2018

There is an increasing demand for thin films with tailored properties, which requires the use and control of adequate deposition techniques. Ion beam sputter deposition (IBSD) is a physical vapor deposition (PVD) technique that is capable of fulfilling the technological challenges. In contrast to other PVD techniques, IBSD offers a unique opportunity to tailor the properties of the film-forming particles (sputtered target and scattered primary particles) and, hence, thin film properties. This is related to the fact that the generation and acceleration of the primary particles from the ion beam source, the generation of film-forming particles at the target, and thin film growth on the substrate are spatially separated. Thus, by changing ion beam parameters (ion species and ion energy) and geometrical parameters (ion incidence angle and emission angle), the energy distributions of the film-forming particles are modified. Even though in use for several decades, IBSD was not investigated systematically until lately. Utilizing the full potential of IBSD requires a comprehensive understanding of the physical processes. This tutorial describes the systematics of IBSD: The correlation between process parameters, properties of the film-forming particles, and thin film properties. The most important process parameters are the scattering geometry and the primary particle species. Depending on the material, different film properties can be influenced. Examples are adhesion, structural properties, composition, surface roughness, mass density, optical properties, stress, and electrical resistivity. In addition to the experimental results, fundamental physical aspects, experimental setups, and techniques for thin film deposition and particle characterization are described.
Construction and validation of a statistical model for the nonlinear Kelvin-Helmholtz instability under compressible, multimode conditions
Authors: Shimony A. , Wan W. C. , Klein S. R. , Kuranz C. C. , Drake R. P. , Shvarts D. , Malamud G.
Published: December 2018

A new model for the evolution of compressible, multimode Kelvin-Helmholtz (KH) instability is presented. The model is built upon compressible single vortex evolution and two-vortex interaction, resulting in a statistical description of the compressible KH mixing zone evolution. These two building blocks, which, due to complicated compressibility effects and the presence of shock waves, cannot be derived using simple flow models, are validated by novel supersonic high-energy-density physics experiments. The model was validated against numerical simulations, experimental results, and previous phenomenological models, confirming the compressible KH scaling law in the self-similar regime in good agreement with simulations and a compilation of experimental data. Moreover, the model extends and confirms the logical validity of previous work, done in the incompressible regime. Therefore, it sheds new light on the evolution of compressible shear layers up to the self-similar regime.
Stability of latent pathogen infection model with CTL immune response and saturated cellular infection
Authors: Elaiw A. M. , Almatrafi A. A. , Hobiny A. D. , Abbas I. A.
Published: December 2018

We propose a pathogen dynamics model with CTL immune response and both pathogenic and cellular infections. Both actively infected cells and latently infected cells are incorporated into the model. The infected-susceptible and pathogen-susceptible infection rates are given by saturated incidence. Three distributed time delays are considered. The existence and global stability of the equilibria are determined by two threshold parameters, the basic reproduction number and the CTL response activation number. The global stability of the three equilibria are proven using Lyapunov method. We solve the system of delay differential equations numerically to support the theoretical results.
Asymmetric oxidation of 1,3-propanediols to chiral hydroxyalkanoic acids by Rhodococcus sp. 2N
Authors: Kikukawa Hiroshi , Koyasu Rena , Yasohara Yoshihiko , Ito Noriyuki , Mitsukura Koichi , Yoshida Toyokazu
Published: December 2018

Rhodococcus sp. 2N was found as a 1,3-propanediols-oxidizing strain from soil samples through enrichment culture using 2,2-diethyl-1,3-propanediol (DEPD) as the sole carbon source. The culture condition of the strain 2N was optimized, and the highest activity was observed when 0.3% (w/v) DEPD was added in the culture medium as an inducer. Chiral HPLC analysis of the hydroxyalkanoic acid converted from 2-ethyl-2-methyl-1,3-propanediol (EMPD) revealed that the strain 2N catalyzed the (R)-selective oxidation of EMPD. The reaction products and intermediates from DEPD and EMPD were identified by nuclear magnetic resonance analyses, and the results suggested that only one hydroxymethyl group of the propanediols was converted to carboxy group via two oxidation steps. Under optimized conditions and after a 72-h reaction time, the strain 2N produced 28 mM (4.1 g/L) of 2-(hydroxymethyl)-2-methylbutanoic acid from EMPD with a molar conversion yield of 47% and 65% ee (R).
Rab5 GTPases are required for optimal TORC2 function
Authors: Locke Melissa N. , Thorner Jeremy
Published: December 2018

Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis. In budding yeast (Saccharomyces cerevisiae), the essential downstream effector of TORC2 is protein kinase Ypk1 and its paralog Ypk2. Muk1, a Rab5-specific guanine nucleotide exchange factor (GEF), was identified in our prior global screen for candidate Ypk1 targets. We confirm here that Muk1 is a substrate of Ypk1 and demonstrate that Ypk1-mediated phosphorylation stimulates Muk1 function in vivo. Strikingly, yeast lacking its two Rab5 GEFs (Muk1 and Vps9) or its three Rab5 paralogs (Vps21/Ypt51, Ypt52, and Ypt53) or overexpressing Msb3, a Rab5-directed GTPase-activating protein, all exhibit pronounced reduction in TORC2-mediated phosphorylation and activation of Ypk1. Vps21 coimmunoprecipitates with TORC2, and immuno-enriched TORC2 is less active in vitro in the absence of Rab5 GTPases. Thus, TORC2-dependent and Ypk1-mediated activation of Muk1 provides a control circuit for positive (self-reinforcing) up-regulation to sustain TORC2-Ypk1 signaling.
IL-17R–EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells
Authors: Chen Xing , Cai Gang , Liu Caini , Zhao Junjie , Gu Chunfang , Wu Ling , Hamilton Thomas A. , Zhang Cun-jin , Ko Jennifer , Zhu Liang , Qin Jun , Vidimos Allison , Koyfman Shlomo , Gastman Brian R. , Jensen Kim B. , Li Xiaoxia
Published: December 2018

Lrig1 marks a distinct population of stem cells restricted to the upper pilosebaceous unit in normal epidermis. Here we report that IL-17A–mediated activation of EGFR plays a critical role in the expansion and migration of Lrig1+ stem cells and their progenies in response to wounding, thereby promoting wound healing and skin tumorigenesis. Lrig1-specific deletion of the IL-17R adaptor Act1 or EGFR in mice impairs wound healing and reduces tumor formation. Mechanistically, IL-17R recruits EGFR for IL-17A–mediated signaling in Lrig1+ stem cells. While TRAF4, enriched in Lrig1+ stem cells, tethers IL-17RA and EGFR, Act1 recruits c-Src for IL-17A–induced EGFR transactivation and downstream activation of ERK5, which promotes the expansion and migration of Lrig1+ stem cells. This study demonstrates that IL-17A activates the IL-17R–EGFR axis in Lrig1+ stem cells linking wound healing to tumorigenesis.