bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling of Durum Wheat Yield Based on Sentinel-2 Imagery
Authors: Cavalaris Chris , Megoudi Sofia , Maxouri Maria , Anatolitis Konstantinos , Sifakis Marios , Levizou Efi , Kyparissis Aris
Published: July 2021

In this study, a modelling approach for the estimation/prediction of wheat yield based on Sentinel-2 data is presented. Model development was accomplished through a two-step process: firstly, the capacity of Sentinel-2 vegetation indices (VIs) to follow plant ecophysiological parameters was established through measurements in a pilot field and secondly, the results of the first step were extended/evaluated in 31 fields, during two growing periods, to increase the applicability range and robustness of the models. Modelling results were examined against yield data collected by a combine harvester equipped with a yield-monitoring system. Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI) were examined as plant signals and combined with Normalized Difference Water Index (NDWI) and/or Normalized Multiband Drought Index (NMDI) during the growth period or before sowing, as water and soil signals, respectively. The best performing model involved the EVI integral for the 20 April–31 May period as a plant signal and NMDI on 29 April and before sowing as water and soil signals, respectively (R2 = 0.629, RMSE = 538). However, model versions with a single date and maximum seasonal VIs values as a plant signal, performed almost equally well. Since the maximum seasonal VIs values occurred during the last ten days of April, these model versions are suitable for yield prediction.
How Phosphorus Fertilization Alleviates the Effect of Salinity on Sugar Beet (Beta vulgaris L.) Productivity and Quality
Authors: Bouras Hamza , Bouaziz Ahmed , Bouazzama Bassou , Hirich Abdelaziz , Choukr-Allah Redouane
Published: July 2021

Salinity is a major problem affecting agriculture in many regions of the world, including Morocco. The best agronomic practices such as fertilization are used to cope with salinity stress and improve productivity under saline conditions. The objective of this study is to evaluate the interactive effect of phosphorus and salinity on sugar beet (Beta vulgaris L.) cv. “Sporta” productivity and quality. A field experiment was carried out, testing three levels of irrigation water salinity (ECw = 0.7; 4, 8, and 12 dS·m−1) and three levels of phosphorus (100, 120, and 140 kg P2O5·ha−1) organized in a split-plot design with three replicates. This research was conducted in the Tadla region (center of Morocco) during two seasons in 2019 and 2020. The obtained results show that irrigation water salinity had a negative effect on most growth and productivity parameters. For instance, sugar beet yield reduced by 21% and by 26% under saline irrigation, with an EC value equal to 4 and 8 dS·m−1, respectively, compared to the control during the 2018–2019 season, and by 1%, 19%, and 27% under saline irrigation, with an EC value equal to 4 and 8 and 12 dS·m−1, respectively compared to the control (0.7 dS·m−1) during the 2019–2020 season. Total sugar content was significantly increased by 5% and 7%, respectively, under saline irrigation, with an EC value of 4 and 8 dS·m−1, respectively, as compared with the control in the first growing season in 2018–2019. However, in the second growing season (2019–2020), only the highest level of saline water (EC = 12 dS·m−1) significantly increased in sugar content by 15% compared to the control. Regarding the P fertilization effect, it was found that a P rate of 120 kg P2O5·ha−1 was enough to improve the yield and sugar content of sugar beet under the tested salinity levels. Thus, P fertilization could be one of the best practices to enhance sugar beets’ tolerance of salinity. To obtain a maximum root and sugar yield under saline water, it is recommended to apply a phosphorus dose of 120 kg P2O5·ha−1.
Interactions between Plants and Plant-Soil in Functionally Complex Mixtures including Grass Pea, Faba Bean and Niger, Intercropped with Oilseed Rape
Authors: Bousselin Xavier , Cassagne Nathalie , Baux Alice , Valantin-Morison Muriel , Herrera Juan Manuel , Lorin Mathieu , Hédan Marie , Fustec Joëlle
Published: July 2021

Winter oilseed rape (OSR) can be grown intercropped with frost-sensitive service plant mixtures. This practice may reduce weed pressure and contribute to providing N for OSR after service plant freezing. However, there is little knowledge of how plants interact together and with the soil in diverse annual crop mixtures. To assess these interactions, two contrasting legume service plants were selected: faba bean and grass pea, as well as a non-legume, the niger plant. OSR and the legumes were then grown in mesocosms alone or intercropped in mixtures of two to four species. The biomass, N contents, N2 fixation, and soil substrate-induced respiration were measured. A single species mostly drove the total dry biomass and the amount of N accumulated by the cover, OSR and faba bean for dry weight and N contents, respectively. Grass pea was highly sensitive to competition with OSR, and its N2 fixation was lower than that of faba bean. The addition of niger did not lead to additional N2 fixation of legumes or total N accumulation and contributed to reducing OSR biomass. The specific composition of the plant mixture did not explain the soil microorganism activity.
Cationic Peptidomimetic Amphiphiles Having a N-Aryl- or N-Naphthyl-1,2,3-Triazole Core Structure Targeting Clostridioides (Clostridium) difficile: Synthesis, Antibacterial Evaluation, and an In Vivo C. difficile Infection Model
Authors: Mahadari Muni Kumar , Jennepalli Sreenu , Tague Andrew J. , Putsathit Papanin , Hutton Melanie L. , Hammer Katherine A. , Knight Daniel R. , Riley Thomas V. , Lyras Dena , Keller Paul A. , Pyne Stephen G.
Published: July 2021

Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and limited, and thus inexpensive drug treatments for C. difficile infection (CDI) with improved efficacy and specificity are urgently needed. To improve the solubility of our cationic amphiphilic 1,1′-binaphthylpeptidomimetics developed earlier that showed promise in an in vivo murine CDI model we have synthesized related compounds with an N-arytriazole or N-naphthyltriazole moiety instead of the 1,1′-biphenyl or 1,1′-binaphthyl moiety. This modification was made to increase the polarity and thus water solubility of the overall peptidomimetics, while maintaining the aromatic character. The dicationic N-naphthyltriazole derivative 40 was identified as a C. difficile-selective antibacterial with MIC values of 8 µg/mL against C. difficile strains ATCC 700057 and 132 (both ribotype 027). This compound displayed increased water solubility and reduced hemolytic activity (32 µg/mL) in an in vitro hemolysis assay and reduced cytotoxicity (CC50 32 µg/mL against HEK293 cells) relative to lead compound 2. Compound 40 exhibited mild efficacy (with 80% survival observed after 24 h compared to the DMSO control of 40%) in an in vivo murine model of C. difficile infection by reducing the severity and slowing the onset of disease.
Healthberry 865® and Its Related, Specific, Single Anthocyanins Exert a Direct Vascular Action, Modulating Both Endothelial Function and Oxidative Stress
Authors: Carrizzo Albino , Lizio Rosario , Di Pietro Paola , Ciccarelli Michele , Damato Antonio , Venturini Eleonora , Iannece Patrizia , Sommella Eduardo , Campiglia Pietro , Ockermann Philipp , Vecchione Carmine
Published: July 2021

In recent years, epidemiological studies have identified a relationship between diet and cerebro–cardiovascular disease (CVD). In this regard, there is a promising dietary group for cardiovascular protection are polyphenols, especially anthocyanins. Vascular reactivity studies were performed using Healthberry 865® and constituent single anthocyanins to characterize vasomotor responses; immunofluorescence analysis with dichlorofluorescein diacetate and dihydroethidium were used to evaluate nitric oxide and oxidative stress; lucigenin assay was used to measure NADPH oxidase activity; and gel electrophoresis and immunoblotting were used to dissect the molecular mechanisms involved. We demonstrated that Healthberry 865® exerts an important vasorelaxant effect of resistance artery functions in mice. Its action is mediated by nitric oxide release through the intracellular signaling PI3K/Akt. Moreover, behind its capability of modulating vascular tone, it also exerts an important antioxidant effect though the modulation of the NADPH oxidase enzyme. Interestingly, its cardiovascular properties are mediated by the selective action of different anthocyanins. Finally, the exposure of human dysfunctional vessels to Healthberry 865® significantly reduces oxidative stress and improves NO bioavailability. Although further investigations are needed, our data demonstrate the direct role of Healthberry 865® on the modulation of vasculature, both on the vasorelaxation and on oxidative stress; thus, supporting the concept that a pure mixture of anthocyanins could be helpful in preventing the onset of vascular dysfunction associated with the development of CVD.
Associations of Human Colorectal Adenoma with Serum Biomarkers of Body Iron Stores, Inflammation and Antioxidant Protein Thiols
Authors: Schöttker Ben , Gào Xīn , Jansen Eugène HJM , Brenner Hermann
Published: July 2021

Red and processed meat consumption and obesity are established risk factors for colorectal adenoma (CRA). Adverse changes in biomarkers of body iron stores (total serum iron, ferritin, transferrin and transferrin saturation), inflammation (high-sensitivity C-reactive protein [hs-CRP]) and anti-oxidative capacity (total of thiol groups (-S-H) of proteins [SHP]) might reflect underlying mechanisms that could explain the association of red/processed meat consumption and obesity with CRA. Overall, 100 CRA cases (including 71 advanced cases) and 100 CRA-free controls were frequency-matched on age and sex and were selected from a colonoscopy screening cohort. Odds ratios (OR) and 95% confidence intervals (95%CI) for comparisons of top and bottom biomarker tertiles were derived from multivariable logistic regression models. Ferritin levels were significantly positively associated with red/processed meat consumption and hs-CRP levels with obesity. SHP levels were significantly inversely associated with obesity. Transferrin saturation was strongly positively associated with overall and advanced CRA (ORs [95%CIs]: 3.05 [1.30–7.19] and 2.71 [1.03–7.13], respectively). Due to the high correlation with transferrin saturation, results for total serum iron concentration were similar (but not statistically significant). Furthermore, SHP concentration was significantly inversely associated with advanced CRA (OR [95%CI]: 0.29 [0.10–0.84]) but not with overall CRA (OR [95%CI]: 0.65 [0.27–1.56]). Ferritin, transferrin, and hs-CRP levels were not associated with CRA. High transferrin saturation as a sign of iron overload and a low SHP concentration as a sign of redox imbalance in obese patients might reflect underlying mechanisms that could in part explain the associations of iron overload and obesity with CRA.
Identification of L-Cysteinamide as a Potent Inhibitor of Tyrosinase-Mediated Dopachrome Formation and Eumelanin Synthesis
Authors: Lee Hyun Kyung , Ha Jae Won , Hwang Yun Jeong , Boo Yong Chool
Published: July 2021

The purpose of this study is to identify amino acid derivatives with potent anti-eumelanogenic activity. First, we compared the effects of twenty different amidated amino acids on tyrosinase (TYR)-mediated dopachrome formation in vitro and melanin content in dark-pigmented human melanoma MNT-1 cells. The results showed that only L-cysteinamide inhibited TYR-mediated dopachrome formation in vitro and reduced the melanin content of cells. Next, the antimelanogenic effect of L-cysteinamide was compared to those of other thiol compounds (L-cysteine, N-acetyl L-cysteine, glutathione, L-cysteine ethyl ester, N-acetyl L-cysteinamide, and cysteamine) and positive controls with known antimelanogenic effects (kojic acid and β-arbutin). The results showed the unique properties of L-cysteinamide, which effectively reduces melanin content without causing cytotoxicity. L-Cysteinamide did not affect the mRNA and protein levels of TYR, tyrosinase-related protein 1, and dopachrome tautomerase in MNT-1 cells. L-Cysteinamide exhibited similar properties in normal human epidermal melanocytes (HEMs). Experiments using mushroom TYR suggest that L-cysteinamide at certain concentrations can inhibit eumelanin synthesis through a dual mechanism by inhibiting TYR-catalyzed dopaquinone synthesis and by diverting the synthesized dopaquinone to the formation of DOPA-cysteinamide conjugates rather than dopachrome. Finally, L-cysteinamide was shown to increase pheomelanin content while decreasing eumelanin and total melanin contents in MNT-1 cells. This study suggests that L-cysteinamide has an optimal structure that can effectively and safely inhibit eumelanin synthesis in MNT-1 cells and HEMs, and will be useful in controlling skin hyperpigmentation.
Tuning Bandgaps of Mixed Halide and Oxide Perovskites CsSnX3 (X=Cl, I), and SrBO3 (B=Rh, Ti)
Authors: Wen Hongzhe , Luo Xuan
Published: July 2021

Perovskites have recently attracted interest in the field of solar energy due to their excellent photovoltaic properties. We herein present a new approach to the composition of lead free perovskites via mixing of halide and oxide perovskites that share the cubic ABX3 structure. Using first-principles calculations through Density Functional Theory, we systematically investigated the atomic and electronic structures of mixed perovskite compounds composed of four cubic ABX3 perovskites. Our result shows that the B and X atoms play important roles in their band structure. On the other hand, their valence bands contributed by O-2p, Rh-4p, and Ti-3p orbitals, and their electronic properties were determined by Rh-O and Ti-O bonds. With new understandings of the electronic properties of cubic halide or oxide perovskites, we lastly combined the cubic perovskites in various configurations to improve stability and tune the bandgap to values desirable for photovoltaic cell applications. Our investigations suggest that the mixed perovskite compound Cs2Sn2Cl3I3Sr2TiRhO6 produced a bandgap of 1.2 eV, which falls into the ideal range of 1.0 to 1.7 eV, indicating high photo-conversion efficiency and showing promise towards solar energy applications.
Calculation Method for Electricity Price and Rebate Level in Demand Response Programs
Authors: Takano Hirotaka , Yoshida Naohiro , Asano Hiroshi , Hagishima Aya , Tuyen Nguyen Duc
Published: July 2021

Demand response programs (DRs) can be implemented with less investment costs than those in power plants or facilities and enable us to control power demand. Therefore, they are highly expected as an efficient option for power supply–demand-balancing operations. On the other hand, DRs bring new difficulties on how to evaluate the cooperation of consumers and to decide electricity prices or rebate levels with reflecting its results. This paper presents a theoretical approach that calculates electricity prices and rebate levels in DRs based on the framework of social welfare maximization. In the authors’ proposal, the DR-originated changes in the utility functions of power suppliers and consumers are used to set a guide for DR requests. Moreover, optimal electricity prices and rebate levels are defined from the standpoint of minimal burden in DRs. Through numerical simulations and discussion on their results, the validity of the authors’ proposal is verified.
Study on the Effects of Ultrasonic Agitation on CO2 Adsorption Efficiency Improvement of Cement Paste
Authors: Liu Lili , Ji Yongsheng , Ma Zhanguo , Gao Furong , Xu Zhishan
Published: July 2021

To realize high-efficiency CO2 absorption by fresh cement paste, ultrasonic vibration technology is introduced into the CO2 absorption test device used in this study. Influences of ultrasonic frequency on the CO2 absorption rate (CO2 AR) and the ultimate absorption amount of fresh cement paste are analyzed. Furthermore, the influencing laws of the CO2 absorption amount (CO2 AA) on the fluidity, pore distribution, and mechanical properties of cement paste under ultrasonic vibrating agitation are analyzed by measuring the variations of the CO2 AA of cement paste. Results demonstrate that ultrasonic vibrating agitation not only can increase the CO2 AR and ultimate absorption amount of fresh cement paste, but also can optimize the internal pore structure of materials and compressive strength of cement-based materials.
Ab Initio Study of Martensitic Transformation in NiTiPt High Temperature Shape Memory Alloys
Authors: Yang Xiaolan , Shang Jiaxiang
Published: July 2021

The crystal structures and martensitic transformation of Ti50Ni50−xPtx alloys (x = 0, 6.25, 8.33, 10.42, 12.5, 18.75, 25) were studied by means of density functional theory (DFT). The computational results indicate that the lattice parameters of Ti-Ni-Pt alloys continuously increase with increasing the Pt content. It is found that at ≤ 12.5 at.% Pt, the martensite structure is monoclinic B19′ phase, and the energy differences between parent and martensite phases (ΔE) decrease slightly with a minimum observed at 6.25 at.% Pt. However, when the Pt content is increased to around 15 at.%, the most stable martensite phase is the orthorhombic B19 structure, and the ΔE increases sharply with Pt concentration. It was found that the phase transition temperatures are closely related to the energy differences ΔE between parent and martensite phases. The electronic structures of martensite B19 and B19′ phases are also discussed.
Deterioration of Sandstone in the Historical and Contemporary Sea Walls upon the Impact of the Natural and Man-Made Hazards
Authors: Wasserman Rina (Irena)
Published: July 2021

The contemporary sea walls built in the pedestrian seashore zone in the City of Acre, Israel, were sided with porous calcarenite sandstone, so-called ‘kurkar’. Kurkar stone has been broadly used as a durable building material in Acre and Jaffa, the Eastern Mediterranean offshore cities, since ancient times. Therefore, the contemporary urban architectural plans obligate kurkar siding in the modern structures erected beside the Old City of Acre. However, a rapid deterioration of kurkar siding had occurred in the contemporary sea walls during only a few years. In contrast, the Historic walls built of kurkar dimensional stone have been still sound. The current study has evaluated the factors and causes of kurkar deterioration in the modern seawalls. It was revealed that the main reason for deterioration was adhering the kurkar siding with cement mortar and the next exposure of adhered siding to the humid and salt-enriched offshore environment with high air pollution.
Publisher’s Note: Have You Ever Looked at the Stars?
Authors: Lin Yu , Craciun Ioana
Published: July 2021

Have you ever looked at the stars [...]
Comparative Study of Equivalent Circuit Models Performance in Four Common Lithium-Ion Batteries: LFP, NMC, LMO, NCA
Authors: Tran Manh-Kien , DaCosta Andre , Mevawalla Anosh , Panchal Satyam , Fowler Michael
Published: July 2021

Lithium-ion (Li-ion) batteries are an important component of energy storage systems used in various applications such as electric vehicles and portable electronics. There are many chemistries of Li-ion battery, but LFP, NMC, LMO, and NCA are four commonly used types. In order for the battery applications to operate safely and effectively, battery modeling is very important. The equivalent circuit model (ECM) is a battery model often used in the battery management system (BMS) to monitor and control Li-ion batteries. In this study, experiments were performed to investigate the performance of three different ECMs (1RC, 2RC, and 1RC with hysteresis) on four Li-ion battery chemistries (LFP, NMC, LMO, and NCA). The results indicated that all three models are usable for the four types of Li-ion chemistries, with low errors. It was also found that the ECMs tend to perform better in dynamic current profiles compared to non-dynamic ones. Overall, the best-performed model for LFP and NCA was the 1RC with hysteresis ECM, while the most suited model for NMC and LMO was the 1RC ECM. The results from this study showed that different ECMs would be suited for different Li-ion battery chemistries, which should be an important factor to be considered in real-world battery and BMS applications.
Engineering and Monitoring 3D Cell Constructs with Time-Evolving Viscoelasticity for the Study of Liver Fibrosis In Vitro
Authors: Cacopardo Ludovica , Ahluwalia Arti
Published: July 2021

Liver fibrosis is generally associated with an over-production and crosslinking of extracellular matrix proteins, causing a progressive increase in both the elastic and viscous properties of the hepatic tissue. We describe a strategy for mimicking and monitoring the mechano-dynamics of the 3D microenvironment associated with liver fibrosis. Cell-laden gelatin hydrogels were crosslinked with microbial transglutaminase using a purpose-designed cytocompatible two-step protocol, which allows for the exposure of cells to a mechanically changing environment during culturing. A bioreactor was re-engineered to monitor the mechanical properties of cell constructs over time. The results showed a shift towards a more elastic (i.e., solid-like) behaviour, which is likely related to an increase in cell stress. The method effectively mimics the time-evolving mechanical microenvironment associated with liver fibrosis and could provide novel insights into pathophysiological processes in which both elastic and viscous properties of tissues change over time.
Role of White Matter Hyperintensities and Related Risk Factors in Vascular Cognitive Impairment: A Review
Authors: Chen Yiyi , Wang Xing , Guan Ling , Wang Yilong
Published: July 2021

White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging markers of cerebral small-vessel disease, which is prevalent in older individuals and closely associated with the occurrence and development of cognitive impairment. The heterogeneous nature of the imaging manifestations of WMHs creates difficulties for early detection and diagnosis of vascular cognitive impairment (VCI) associated with WMHs. Because the underlying pathological processes and biomarkers of WMHs and their development in cognitive impairment remain uncertain, progress in prevention and treatment is lagging. For this reason, this paper reviews the status of research on the features of WMHs related to VCI, as well as mediators associated with both WMHs and VCI, and summarizes potential treatment strategies for the prevention and intervention in WMHs associated with VCI.
Biostimulant Substances for Sustainable Agriculture: Origin, Operating Mechanisms and Effects on Cucurbits, Leafy Greens, and Nightshade Vegetables Species
Authors: Cristofano Francesco , El-Nakhel Christophe , Rouphael Youssef
Published: July 2021

Climate change is a pressing matter of anthropogenic nature to which agriculture contributes by abusing production inputs such as inorganic fertilizers and fertigation water, thus degrading land and water sources. Moreover, as the increase in the demand of food in 2050 is estimated to be 25 to 70% more than what is currently produced today, a sustainable intensification of agriculture is needed. Biostimulant substances are products that the EU states work by promoting growth, resistance to plant abiotic stress, and increasing produce quality, and may be a valid strategy to enhance sustainable agricultural practice. Presented in this review is a comprehensive look at the scientific literature regarding the widely used and EU-sanctioned biostimulant substances categories of silicon, seaweed extracts, protein hydrolysates, and humic substances. Starting from their origin, the modulation of plants’ hormonal networks, physiology, and stress defense systems, their in vivo effects are discussed on some of the most prominent vegetable species of the popular plant groupings of cucurbits, leafy greens, and nightshades. The review concludes by identifying several research areas relevant to biostimulant substances to exploit and enhance the biostimulant action of these substances and signaling molecules in horticulture.
Co-Players in Chronic Pain: Neuroinflammation and the Tryptophan-Kynurenine Metabolic Pathway
Authors: Tanaka Masaru , Török Nóra , Tóth Fanni , Szabó Ágnes , Vécsei László
Published: July 2021

Chronic pain is an unpleasant sensory and emotional experience that persists or recurs more than three months and may extend beyond the expected time of healing. Recently, nociplastic pain has been introduced as a descriptor of the mechanism of pain, which is due to the disturbance of neural processing without actual or potential tissue damage, appearing to replace a concept of psychogenic pain. An interdisciplinary task force of the International Association for the Study of Pain (IASP) compiled a systematic classification of clinical conditions associated with chronic pain, which was published in 2018 and will officially come into effect in 2022 in the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) by the World Health Organization. ICD-11 offers the option for recording the presence of psychological or social factors in chronic pain; however, cognitive, emotional, and social dimensions in the pathogenesis of chronic pain are missing. Earlier pain disorder was defined as a condition with chronic pain associated with psychological factors, but it was replaced with somatic symptom disorder with predominant pain in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) in 2013. Recently clinical nosology is trending toward highlighting neurological pathology of chronic pain, discounting psychological or social factors in the pathogenesis of pain. This review article discusses components of the pain pathway, the component-based mechanisms of pain, central and peripheral sensitization, roles of chronic inflammation, and the involvement of tryptophan-kynurenine pathway metabolites, exploring the participation of psychosocial and behavioral factors in central sensitization of diseases progressing into the development of chronic pain, comorbid diseases that commonly present a symptom of chronic pain, and psychiatric disorders that manifest chronic pain without obvious actual or potential tissue damage.
Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review
Authors: Artym Jolanta , Zimecki Michał , Kruzel Marian L.
Published: July 2021

Pregnancy is a physiological state that demands higher level of nutrients, including vitamins and minerals, for the growth and maintenance of the fetus. Iron deficiency is a part of most common diet deficiencies in pregnancy and has high clinical significance leading to the development of syderopenic anemia and its consequences for mother and child, such as higher risk of perinatal death, susceptibility to infection, intra-uteral growth inhibition, prematurity and low birth weight. Hence, iron supplementation is recommended for pregnant women; however dietary intake of iron from most commercially available formulas is often insufficient due to iron-poor bioavailability, or have undesired side-effects in the gastrointestinal tract, resulting in a discouraging and distrustful attitude to such treatment. The results of numerous studies indicate that diet supplementation with lactoferrin (LTF), an iron-binding protein, may be advantageous in prophylaxis and treatment of iron deficiency anemia. LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes. LTF also protects against infections and inflammatory complications, caused by diagnostic surgical interventions in pregnant women. Beneficial, multidirectional actions of LTF during pregnancy encompass, in addition, inhibition of oxidative stress, normalization of intestine and genital tract microbiota and carbohydrate-lipid metabolism, protection of intestine barrier function, promotion of wound healing, as well as hypotensive, analgesic and antistress actions. Bovine lactoferrin (BLTF) is readily available on the nutritional market and generally recognized as safe (GRAS) for use in human diet.
The Predictive Value of the aCL and Anti-β2GPI at the Time of Acute Deep Vein Thrombosis—A Two-Year Prospective Study
Authors: Perdan-Pirkmajer Katja , Žigon Polona , Boc Anja , Podovšovnik Eva , Čučnik Saša , Mavri Alenka , Rotar Žiga , Ambrožič Aleš
Published: July 2021

Antiphospholipid syndrome (APS) is an important cause of deep vein thrombosis (DVT). According to current APS classification criteria, APS cannot be confirmed until 24 weeks after DVT. This time frame results in frequent discontinuation of anticoagulant treatment before APS is diagnosed. Therefore, the aim of our study was to evaluate the potential predictive value of anticardiolipin (aCL) and anti-β2glycoprotein I (anti-β2GPI) before discontinuation of anticoagulation therapy. Patients with newly diagnosed DVT were included into a 24-month prospective study. All patients received anticoagulant therapy. aCL and anti-β2GPI were determined at inclusion and every four weeks for the first 24 weeks and then one and two years after inclusion. APS was confirmed in 24/221 (10.9%) patients. At the time of acute DVT 20/24 (83.3%), APS patients had positive aCL and/or anti-β2GPI. Two patients had low aCL levels and two were negative at the time of acute DVT but later met APS criteria due to lupus anticoagulant (LA). Our data indicate that negative aCL and/or anti-β2GPI at the time of acute DVT make further aPL testing unnecessary; however, LA should be determined after discontinuation of anticoagulant therapy. Positive aCL and/or anti-β2GPI at the time of acute DVT have a strong positive predictive value for APS and may support therapeutic decisions.
Impact of Propofol Bolus Administration on the Nociceptive Flexion Reflex Threshold and Bispectral Index in Children—A Case Series
Authors: Mauritz Maximilian David , Uhlenberg Felix , Vettorazzi Eik , Ebenebe Chinedu Ulrich , Singer Dominique , Deindl Philipp
Published: July 2021

We analyzed the impact of propofol administration during continuous sedation and analgesia on the nociceptive flexion reflex threshold (NFRT) and Bispectral Index (BIS) in ventilated children. We examined patients who received propofol before planned endotracheal suctioning. Patients were clinically assessed using the modified Face, Legs, Activity, Cry, Consolability (mFLACC) scale and COMFORT-B (Comfort Behavior) scale. We continuously recorded the NFRT and BIS. We recorded 23 propofol administrations in eight patients with an average age of 8.6 ± 3.5 years. The median (minimum-maximum) scores for the mFLACC scale and COMFORT-B scale were 0 (0–5) and 6 (6–17), respectively, before the bolus. The administration of a weight-adjusted propofol bolus of 1.03 ± 0.31 mg/kg resulted in an increase in NFRT and burst-suppression ratio; BIS and electromyogram values decreased. Changes from baseline (95% CI) after propofol bolus administration were BIS −23.9 (−30.8 to −17.1), EMG -10.5 dB (−13.3 to −7.7), SR 14.8 % (5.6 to 24.0) and NFRT 13.6 mA (5.5 to 21.7). Further studies are needed to determine whether sedated children may benefit from objective pain and sedation monitoring with BIS and NFRT.
Incidence of Acute and Chronic Post-Thoracotomy Pain in Pediatric Patients
Authors: Marchetti Giuliano , Vittori Alessandro , Ferrari Fabio , Francia Elisa , Mascilini Ilaria , Petrucci Emiliano , Piga Simone , Pardi Valerio , Cascella Marco , Contini Giorgia , Marinangeli Franco , Inserra Alessandro , Picardo Sergio Giuseppe
Published: July 2021

We studied acute and chronic pain in pediatric patients who underwent thoracotomy for benign disease with a follow-up of at least three months. A telephone interview investigated about the presence of pain and the analgesic therapy in progress. The results were compared with the anesthetic technique, postoperative pain and the adequacy of pain therapy, both during the first week after surgery and at the time of interview. Fifty-six families consented to the study. The mean age of the children at surgery was 2.9 ± 4.5 years, while at the time of the interview was 6.5 ± 4.4 years. We performed different anesthetic strategies: Group A: general anesthesia (36 pts); Group B: general anesthesia and thoracic epidural (10 pts); Group C: general anesthesia and intercostal nerve block (10 pts). During the immediate postoperative period, 21 patients (37.5%) had at least one painful episode. At the time of interview, 3 children (5.3%) had moderate chronic neuropathic (burning) pain on surgical scar. There was no statistically significant difference between the type of anesthesia and the incidence and severity of acute post-operative pain. Despite its limitations, this study confirms the low incidence of chronic post-thoracotomy pain syndrome in children.
Longitudinal Analysis (1994–2020) of Prevalence and Trends of Underweight in Polish Children
Authors: Lemanowicz-Kustra Aleksandra , Borkowska Anna , Brzeziński Michał , Wyszomirski Adam , Szlagatys-Sidorkiewicz Agnieszka
Published: July 2021

Nutritional status disorders are a worldwide problem. Approximately 5.9 million children under the age of five die each year, and 45% of these deaths are related to malnutrition. The aim of the study was to analyse the prevalence of underweight children aged between 6 and 7 years old, living in the Gdańsk, Poland, in the years 1994–2020. The anthropometric parameters of 67,842 children were analysed. BMI (Body Mass Index) value <5 percentile (pc) was defined as underweight. The BMI value was compared to the WHO (World Health Organization) centile charts and the OLAF (research project PL0080) national reference charts. The prevalence of underweight children in relation to the WHO charts was 1.9%; underweight status was found to be more significant in the group of boys (2.1%) than the group of girls (1.7%) (p < 0.001). According to the OLAF centile charts, the underweight figure among all of the study population was 2.1% and no statistical significance between boys (2.1%) and girls (2.0%) was found (p = 0.670). The occurrence of underweight indviduals in the studied group slightly increased in the years 1994–2020. We found a statistically significant increasing linear trend in the analysis of underweight children in our group (p < 0.001), in group of boys (p < 0.001), but not girls (WHO p = 0.603; OLAF p = 0.787). This points to the need to conduct regular screening systems for children and adolescents.
Effect of the COVID-19 Outbreak on Pediatric Patients’ Admissions to the Emergency Department in an Italian Orthopedic Trauma Hub
Authors: Verdoni Fabio , Ricci Martina , Di Grigoli Cristina , Rossi Nicolò , Lombardo Michele Davide Maria , Curci Domenico , Accetta Riccardo , Viganò Marco , Peretti Giuseppe Maria , Mangiavini Laura
Published: July 2021

Background: The rapid diffusion of Coronavirus disease (COVID-19) in Northern Italy led the Italian government to dictate a national lockdown from 12 March 2020 to 5 May 2020. The aim of this observational cohort study is to analyze the differences in the number of pediatric patients’ admission to the Emergency Room (ER) and in the type and causes of injury. Methods: The pediatric population during the pandemic was compared to a similar group of patients admitted to the ER in 2019. Sex, age, triage color-code at admission, cause of trauma and presence of symptoms related to COVID-19 infection, discharge diagnosis and discharge modes were investigated. Results: The lockdown period led to a reduction of 87.0% in ER admissions with a particular decrease in patients older than 12 years old. Moreover, a trend towards more severe codes and an increase in home-related injuries were observed during the pandemic, whereas the diagnosis of fracture was less frequent in the pre-pandemic group (p < 0.0001). Conclusions: A significant decrease in the ER attendances was reported during the lockdown. A shift in the cause and type of injury was observed; only the most serious traumas sought medical care with a higher percentage of severe triage codes and fractures.
Juvenile Idiopathic Arthritis Associated Uveitis
Authors: Carlsson Emil , Beresford Michael W. , Ramanan Athimalaipet V. , Dick Andrew D. , Hedrich Christian M.
Published: July 2021

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The development of associated uveitis represents a significant risk for serious complications, including permanent loss of vision. Initiation of early treatment is important for controlling JIA-uveitis, but the disease can appear asymptomatically, making frequent screening procedures necessary for patients at risk. As our understanding of pathogenic drivers is currently incomplete, it is difficult to assess which JIA patients are at risk of developing uveitis. Identification of specific risk factors for JIA-associated uveitis is an important field of research, and in this review, we highlight the genomic, transcriptomic, and proteomic factors identified as potential uveitis risk factors in JIA, and discuss therapeutic strategies.
Sustainability of Wetlands in the Eyes of the New Generation of Environmental Engineering Students
Authors: Amiraslani Farshad
Published: July 2021

This research paper investigates the general understanding and skills of young third-year environmental engineering students concerning the criteria for monitoring wetlands. Students were asked to describe approaches, data, and final solutions to identify and/or eliminate wetland odor. Over half of the students (55%) did not consider the “identification” strategy by which to determine the source of unexpected odors. The rest gave answers focused on “restoration” (24%) and “prevention” (15%) strategies, while 6% of the answers were unrelated. In fact, without knowing the causes and without thinking about the necessity/importance of visiting/surveying the site, students came up with a priori solutions. In their mind, the immediate cause of the odor could be a disturbed or unbalanced distribution/composition of ions, salts, or microbes in the water. Indeed, most data types (71%) were those related to “water”. As the final solution, 50% of responses considered “physical” followed by “legal and planning” solutions (32%). Each factor, including “Chemical” and “Biological”, constituted 9% of the answers. This research highlights engineering students’ communication skills, critical thinking and problem-solving abilities by contemplating class activities that simulate real-world situations. The research presumes that these engineering student cohorts represent typical student communities worldwide. Such findings contribute to policymaking in the engineering education system on a larger scale.
Integrative Taxonomy of New Zealand Stenopodidea (Crustacea: Decapoda) with New Species and Records for the Region
Authors: Schnabel Kareen E. , Kou Qi , Xu Peng
Published: July 2021

The New Zealand fauna of the crustacean infraorder Stenopodidea, the coral and sponge shrimps, is reviewed using both classical taxonomic and molecular tools. In addition to the three species so far recorded in the region, we report Spongicola goyi for the first time, and formally describe three new species of Spongicolidae. Following the morphological review and DNA sequencing of type specimens, we propose the synonymy of Spongiocaris yaldwyni with S. neocaledonensis and review a proposed broad Indo-West Pacific distribution range of Spongicoloides novaezelandiae. New records for the latter at nearly 54° South on the Macquarie Ridge provide the southernmost record for stenopodidean shrimp known to date.
Protecting Physical Layer Secret Key Generation from Active Attacks
Authors: Mitev Miroslav , Chorti Arsenia , Belmega E. Veronica , Poor H. Vincent
Published: July 2021

Lightweight session key agreement schemes are expected to play a central role in building Internet of things (IoT) security in sixth-generation (6G) networks. A well-established approach deriving from the physical layer is a secret key generation (SKG) from shared randomness (in the form of wireless fading coefficients). However, although practical, SKG schemes have been shown to be vulnerable to active attacks over the initial “advantage distillation” phase, throughout which estimates of the fading coefficients are obtained at the legitimate users. In fact, by injecting carefully designed signals during this phase, a man-in-the-middle (MiM) attack could manipulate and control part of the reconciled bits and thus render SKG vulnerable to brute force attacks. Alternatively, a denial of service attack can be mounted by a reactive jammer. In this paper, we investigate the impact of injection and jamming attacks during the advantage distillation in a multiple-input–multiple-output (MIMO) system. First, we show that a MiM attack can be mounted as long as the attacker has one extra antenna with respect to the legitimate users, and we propose a pilot randomization scheme that allows the legitimate users to successfully reduce the injection attack to a less harmful jamming attack. Secondly, by taking a game-theoretic approach we evaluate the optimal strategies available to the legitimate users in the presence of reactive jammers.
ABCDP: Approximate Bayesian Computation with Differential Privacy
Authors: Park Mijung , Vinaroz Margarita , Jitkrittum Wittawat
Published: July 2021

We developed a novel approximate Bayesian computation (ABC) framework, ABCDP, which produces differentially private (DP) and approximate posterior samples. Our framework takes advantage of the sparse vector technique (SVT), widely studied in the differential privacy literature. SVT incurs the privacy cost only when a condition (whether a quantity of interest is above/below a threshold) is met. If the condition is sparsely met during the repeated queries, SVT can drastically reduce the cumulative privacy loss, unlike the usual case where every query incurs the privacy loss. In ABC, the quantity of interest is the distance between observed and simulated data, and only when the distance is below a threshold can we take the corresponding prior sample as a posterior sample. Hence, applying SVT to ABC is an organic way to transform an ABC algorithm to a privacy-preserving variant with minimal modification, but yields the posterior samples with a high privacy level. We theoretically analyzed the interplay between the noise added for privacy and the accuracy of the posterior samples. We apply ABCDP to several data simulators and show the efficacy of the proposed framework.
Strong Coupling Optomechanics Mediated by a Qubit in the Dispersive Regime
Authors: Aporvari Ahmad Shafiei , Vitali David
Published: July 2021

Cavity optomechanics represents a flexible platform for the implementation of quantum technologies, useful in particular for the realization of quantum interfaces, quantum sensors and quantum information processing. However, the dispersive, radiation–pressure interaction between the mechanical and the electromagnetic modes is typically very weak, harnessing up to now the demonstration of interesting nonlinear dynamics and quantum control at the single photon level. It has already been shown both theoretically and experimentally that if the interaction is mediated by a Josephson circuit, one can have an effective dynamics corresponding to a huge enhancement of the single-photon optomechanical coupling. Here we analyze in detail this phenomenon in the general case when the cavity mode and the mechanical mode interact via an off-resonant qubit. Using a Schrieffer–Wolff approximation treatment, we determine the regime where this tripartite hybrid system behaves as an effective cavity optomechanical system in the strong coupling regime.
Robust Tracker of Hybrid Microgrids by the Invariant-Ellipsoid Set
Authors: Awad Hilmy , Bayoumi Ehab H. E. , Soliman Hisham M. , De Santis Michele
Published: July 2021

This paper introduces a new ellipsoidal-based tracker design to control a grid-connected hybrid direct current/alternating current (DC/AC) microgrid (MG). The proposed controller is robust against both parameters and load variations. The studied hybrid MG is modelled as a nonlinear dynamical system. A linearized model around an operating point is developed. The parameter changes are modelled as norm-bounded uncertainties. We apply the new extended version of the attractive (or invariant) ellipsoid for this tracking problem. Convex optimization is used to obtain the region’s minimal size where the tracking error between the state trajectories and the reference states converges. The sufficient conditions for stability are derived and solved based on linear matrix inequalities (LMIs). The proposed controller’s validity is shown via simulating the hybrid MG with various operational scenarios. In each scenario, the performance of the controller is compared with a recently proposed sliding mode controller. The comparison clearly illustrates the superiority of the developed controller in terms of transient and steady-state responses.
Power Flow Management by Active Nodes: A Case Study in Real Operating Conditions
Authors: Bifaretti Stefano , Bonaiuto Vincenzo , Pipolo Sabino , Terlizzi Cristina , Zanchetta Pericle , Gallinelli Francesco , Alessandroni Silvio
Published: July 2021

The role of distributor system operators is experiencing a gradual but relevant change to include enhanced ancillary and energy dispatch services needed to manage the increased power provided by intermittent distributed generations in medium voltage networks. In this context, the paper proposes the insertion, in strategic points of the network, of specific power electronic systems, denoted as active nodes, which permit the remote controllability of the active and reactive power flow. Such capabilities, as a further benefit, enable the distributor system operators to provide ancillary network services without requiring any procurement with distributed generation systems owners. In particular, the paper highlights the benefits of active nodes, demonstrating their capabilities in reducing the inverse power flow issues from medium to high voltage lines focusing on a network cluster including renewable energy resources. As a further novelty, this study has accounted for a real cluster operated by the Italian distributor system operator Areti. A specific simulation model of the electrical lines has been implemented in DigSilent PowerFactory (DIgSILENT GmbH–Germany) software using real operating data obtained during a 1-year measurement campaign. A detailed cost-benefit analysis has been provided, accounting for different load flow scenarios. The results have demonstrated that the inclusion of active nodes can significantly reduce the drawbacks related to the reverse power flow.
Identification of Similar Seismic Waves Using the Phase-Only Correlation Function and Wavelet Transform
Authors: Moriya Hirokazu
Published: July 2021

Accurately determined acoustic emission (AE) locations provide significant information on fracture systems, such as the orientation of fractures in a geothermal reservoir. To determine the relative source locations among a group of seismic events, similar AE waveforms must be detected and the relative arrival times of the P and S waves must be determined. In this paper, a method to identify similar AE waveforms is proposed, in which wavelet transform scalograms are used to determine the phase-only correlation function. The proposed method was applied to arbitrarily selected seismic waveforms, and its feasibility was evaluated by comparing the results with those obtained when the phase-only correlation function was obtained by using Fourier transform results.