bluuebunny/crossref_metadata_2025 huggingface dataset:
Public Relations Strategy of PDAM Tirtawening in Responding to Consumer Complaints through Social Media (Twitter)
Authors: Hasanah Anisa Nurul , Yuniarti Elsa , Hidayat Dasrun
Published: July 2021

The purpose of this study is to find out how PDAM Tirtawening's public relations strategy in responding to consumer complaints during the Covid-19 pandemic. After the Covid-19 pandemic, there were many changes ranging from social changes, community behavior actions, to changes in public services, especially in Pdam Tirtawening Bandung. This study uses descriptive studies with a skin-skinned approach. Data collection techniques in this study are observations, in-depth interviews with informants that have been determined by researchers consisting of 3 informants. Based on system theory by defining problems, planning and programming, communicating, evaluating this study found the fact that PDAM Tirtawening's Public Relations strategy during the Covid-19 pandemic is still receiving complaints, although the complaint is only submitted through social media twitter therefore PDAM Tirtawening strives as quickly as possible to respond to complaints and problems.
Optimization of Social Media as a Counter to Islamophobia in Australia
Authors: Maghfiroh Shinta Lailatul , Rohma Siti
Published: July 2021

Australia is a multicultural country, but Islamophobia is still developing, so it needs a way to stop that view. This study aims to prove that Islamophobia in the West can be minimized. This paper is a literature study with a political communication approach regarding the optimization of social media as a barrier to Islamophobia in Australia. Data collection comes from literature such as articles, journals, reports, policy briefs, news books, and other sources concerning social media and Islamophobia in Australia. Data analysis techniques were carried out with three stages namely data reduction, data presentation and verification. The object of study in this study is the optimization of social media to counter Islamophobia in Australia by Onepath Networks. The study results state that social media is quite optimal in order to minimize the development of Islamophobia issues. Onepath Network as one of the Islamic organizations in Australia, uses social media to preach. Da'wah is done with videos and documentaries that are shown on Youtube and even cinemas on Islamic dialogue. Since the Onepath Network was formed, Islamophobia in Australia began to diminish and is proven by Muslims who began to participate in various fields, including government, many mosques began to be built and many Islamic schools were established.
Performance of Coconut Hybrids Dwarf X Bido Tall
Authors: Novarianto Hengky , Tulalo Meity A.
Published: July 2021

The desirable future coconut variety characteristics should include (1) short trunk and low height increment, (2) early bearing, (3) high nut yield, and (4) high neera (coconut sugar sap). High yoelding but short coconut palm statures make it easy to harvest the nuts and tap the neera. The Dwarf coconut varieties are generally early bearing with a low height increment and plenty nuts per fruit bunch. The Bido tall coconut bears fruits as early as three years after planting and with high nut yield, a low height increment and a very short trunk. This study aims to evaluate early vegetative growth (2 – 3 years after planting) of eight coconut hybrids derived from combinations of Dwarfs x Bido tall hybridizations. The arrays of hybrid coconuts consisted of hybridization between three Dwarf coconut varieties by Bido tall generated in 2016, and those between five Dwarf coconut varieties by Bido tall generated in 2017. The KHINA-1 hybrid was used as the standard hybrid control. Results of the evaluation showed the evaluated Waingapu Red Dwarf x Bido tall hybrids have the largest stem girth and the highest plant heightOn the other hand, Aromatic Green Dwarf x Bido tall hybrids showed the highest leaf numbers. However, all hybrid combinations showed the same stem girth diameter at two years after planting. At two and three years after planting, the Raja Brown Dwarf x Bido tall hybrids were the tallest, while the Nias Yellow Dwarf x Bido tall coconut hybrids have the highest leaf number. All of the Dwarf x Bido tall coconut hybrids showed good vegetative performance at two and three years after planting. The differences in early vegetative performances among the evaluated Dwarf x Bido tall might indicate the differences in early bearing, high nut yield and high neera characters of the hybrids.
Effect of Surfactant Addition on The Physico-Chemical Properties and Stability of Virgin Coconut Oil Nanoemulsions
Authors: Trivana Linda , Suyatma Nugraha E. , Hunaefi Dase , Munarso S. Joni
Published: July 2021

Virgin coconut oil (VCO) is high quality coconut oil and categorized as the healthiest oil and functional foods. Based on these benefits, the development of a VCO in emulsion product might increase the human consumption of coconut oil because consumers dislike the only taste of pure VCO. The aim of this study was to develop the water compatible form of VCO through nano-emulsification. The effect of different types and amounts of surfactants (Tween 80 and Span 80) on the physio-chemical characteristic of emulsion containing VCO was investigated. VCO based emulsions were prepared with the aid of Ultra-Turrax homogenizer. Emulsions were developed by adding and mixing VCO with surfactants. The ratio of Tween 80 and Span 80 used were 0:10, 2.5:7.5, 5:5, 7.5:2.5, and 10:0. The droplet size of nanoemulsions consisting of Tween 80:Span 80 (0:10, 2.5:7.5, 5:5, 7.5:2.5, and 10:0) were 1.343, 0.606, 0.829, 1.439, and 2.506µm, respectively. Based on the TEM analysis and polydispersity index (PDI) >0.5 showed the oil droplets are in not uniform shape, indicating a unstable emulsion. VCO emulsion with ratio Tween 80:Span 80 (0:10) obtained a homogeneous emulsion (stable) compare than that of others and w/o type emulsion. The stability of emulsion is evaluated by turbidity measurement using UV-VIS spectrophotometer with wavelength 502 nm. A combination of  treatments (ambient condition, thermal treatmeant (40°C)), and centrifuge) of VCO emulsion has resulted on thermal treat, the turbidity measured from the emulsion was higher than the other emulsion, reflecting the presence of the smaller droplets in this emulsion.
Lists of Opportunities: My Experience as a School Librarian During the COVID-19 Pandemic
Authors: Morley Bonnie
Published: July 2021

In this paper I share my experiences, opinions and perspectives of running a school library during the COVID-19 pandemic. I discuss the difficulties and problems I have encountered, but also the opportunities for creativity that have presented themselves. From experiencing government cutbacks to layoffs and school closures, I discuss my feelings and frustrations about COVID-19 and how it prevented me from doing my job. I demonstrate how the pandemic heightened the feeling of isolation and loneliness in a job that can already make one feel disconnected; I highlight the importance and need for human connection. I also examine the new creative opportunities that working during a pandemic has given me, like asynchronous programming, collection development, professional development and a chance to experiment or renovate. This paper is meant to highlight the importance of school libraries and start a discussion of our role before and after the pandemic. Advocacy helps ensure that school libraries remain open. My goal is to give a glimpse of day-to-day library practice in a school library during the pandemic and share ideas and information with the library and information community. My views and opinions are my own, and the context will be different in every school.
Prevalencia mensual de trastorno de ansiedad generalizada durante la pandemia por Covid-19 en México
Authors: Gaitán-Rossi Pablo , Pérez-Hernández Víctor , Vilar-Compte Mireya , Teruel-Belismelis Graciela
Published: July 2021

Objetivo. Estimar la prevalencia de ansiedad generalizada (GAD, por sus siglas en inglés) entre abril y junio de 2020. Material y métodos. Diseño transversal repetido basado en la Encovid-19, una serie de encuestas telefónicas mensuales con muestras representativas de México (N= 833-1 674). El cuestionario incluye la escala GAD-2 y en julio se añadió la GAD-7; se examinó su validez interna con análisis facto­rial confirmatorio y su validez concurrente con variables sociodemográficas. Con la GAD-7 como criterio, se calculó la validez predictiva de la GAD-2. Se estimó la prevalencia mensual con la GAD-2. Resultados. La GAD-7 y la GAD- 2 son confiables y válidas. La GAD-2 tiene una sensibilidad de 0.87 y una especificidad de 0.90. La prevalencia mensual se mantuvo alta y estable, entre 30.7 y 32.6%. El GAD se concentró en mujeres, personas desocupadas y de bajo nivel socioeconómico. Conclusiones. El GAD es un problema de salud pública que se agravó con la pandemia por Covid-19.
Recomendaciones de la Sociedad Mexicana de Oncología para la vacunación contra Covid-19 en personas con cáncer en México
Authors: Soto-Pérez-de-Celis Enrique , Arrieta Oscar , Bargalló-Rocha Enrique , Campos-Gómez Saúl , Chávarri-Guerra Yanin , Chávez-Nogueda Jessica , González-Lara Fernanda , Pérez-Jacobo Fernando , Martínez-Said Héctor
Published: July 2021

No disponible
Inferencia causal en análisis basados en datos de vigilancia epidemiológica para Covid-19
Authors: Lajous Martín
Published: July 2021

No disponible.
OPTIMIZATION OF THE ACEH BEEF CATTLE PRODUCTION AND PROCESS USING SWOT ANALYSIS AND INDUSTRIAL SUPPLY CHAIN APPROACHES
Authors: Mizan Us Khairol , Yaman M. Aman , Fradinata Edy
Published: July 2021

The problem in management process and production of Aceh beef cattle farms in Aceh Besar  has not been explored. This study aimed to determine the basic system of supply chain for the Aceh beef cattle production in Central Aceh Besar developed a model for optimizing the supply chain management and sustainability to increase productivity and business efficiency. This research used SWOT analysis and industrial supply chain approaches. The results showed that the current supply chain system of the Aceh beef cattle industry in Aceh Besar which has been running so far, needs to be strengthened to increase production and population of Aceh beef cattle in the future.  There were 4 issues were identified: time, 29.6% faster than the current supply chain supply time;  method, 60% no longer needed a business intermediary; cost, 21.4% of the live weight price of cattle was cheaper than the live weight price of current supply chain cattle; and stages, 30.8% shorter than the ongoing supply chain stages. The result of the SWOT analysis matrix showed that the SO (strength-opportunities) strategy was the main strategy for business developing of Aceh beef cattle in Central Aceh. In conclusion, it is necessary to optimize the implementation of the supply chain of Aceh Cattle Industry at Central Aceh by utilizing its strengths and suppressing the existing weaknesses from the breeding production to marketing process.
Evidências Psicométricas das Dimensões da Qualidade de Serviços de um Bairro Urbanco
Authors: Pastana Sheila Trícia Guedes , Formiga Nilton Soares
Published: July 2021

Este estudo visa desenvolver e validar uma escala relacionada à qualidade dos serviços do bairro, a partir da perspectiva das pessoas que habitam as áreas sul e leste na cidade de Natal-RN. Com base no conceito e teoria da gestão urbana, marketing e satisfação residencial, o estudo apresenta escala para medir as dimensões da qualidade dos serviços no bairro como forma de contribuir para sua gestão urbana e, por conseguinte, das cidades, auxiliando no planejamento e tomada de decisão por parte dos gestores, promoção do bem-estar, qualidade de vida, serviços e ambientes urbanos acolhedores, para atrair investimentos públicos e privados. A metodologia utilizada foi do tipo quantitativo, descritivo e correlacional, através de levantamento. A coleta de dados foi feita por meio de um questionário estruturado, tendo alcançado 701 respondentes, distribuídos em quatro amostras. Para a análise dos dados adotou-se um estudo subdividido em três etapas, a saber: 1) estatística descritiva e representatividade de conteúdo, 2) análise exploratória e 3) análise confirmatória da estrutura fatorial. Os resultados revelaram que a escala Dimensões da Qualidade dos Serviços no Bairro (DQSB) é consistente em sua estrutura tetrafatorial, não havendo diferenças entre as zonas urbanas relativas à mensuração desse construto, comprovando-se assim o mesmo nível de qualidade dos serviços.
A metafluid with multistable density and internal energy states
Authors: Peretz Ofek , Abu Ezra Ben , Zigelman Anna , Givli Sefi , Gat Amir
Published: July 2021

The efficiency, operation range, and environmental safety of energy and refrigeration cycles are determined by the thermodynamic properties of available fluids. We here suggest combining gas, liquid and multistable elastic capsules to create an artificial fluid with a multitude of stable states. We study, theoretically and experimentally, the suspension’s internal energy, equilibrium pressure-density relations and their stability for both adiabatic and isothermal processes. We show that the elastic multistability of the capsules endows the fluid with multistable thermodynamic properties, including the ability of capturing and storing energy at standard atmospheric conditions, not found in naturally available fluids.
Utilization of galactomannan from spent coffee grounds as coagulant aid to treat synthetic Congo red wastewater
Authors: Kristianto Hans , Saraswati Sekar Astari , Prasetyo Susiana , Sugih Asaf K
Published: July 2021

Over the last few years, there is a significant growth in research exploring natural based coagulant due to its various benefits to decrease or even substitute the usage of inorganic chemical coagulants. Polysaccharide based coagulant and coagulant aid is a promising source for this purpose, due to its abundance. In this study, we reported utilization of galactomannan extracted from spent coffee grounds as natural coagulant aid in coagulation of Congo red synthetic wastewater. The coagulation was done at fixed dosage of FeCl3 (160 mg/L) and pH of 6. The effect of galactomannan as coagulant aid was observed by varying galactomannan dosage (0-140 mg/L) and Congo red concentration (20–70 mg/L). It was found that galactomannan as coagulant aid could increase the removal of Congo red, around 30–90% removal, depends on Congo red concentration, compared FeCl3 only (0–65%). The coagulation adsorption study was also investigated using Langmuir, Freundlich, and Brunauer – Emmet – Teller (BET) isotherm models. It was found that Congo red coagulation using FeCl3 only was following Langmuir isotherm, indicating monolayer – homogenous formation during the coagulation. On the other hand, with the presence of galactomannan the coagulation was best described by BET isotherm, indicating multilayer – heterogeneous adsorption, possibly due to interparticle bridging of galactomannan during colloid aggregation. The findings in this study suggest synergistic effect of galactomannan and FeCl3 in the coagulation process and proved potential of galactomannan from spent coffee grounds as natural coagulant aid.
NaYS2:Er3+ - a highly efficient NIR II response multi-photon up-conversion phosphor
Authors: Yin Xiumei , Xu Wen , Zhu Ge , Ji Yanan , Xiao Qi , Dong Xinyao , He Ming , Cao Baosheng , Zhou Na , Luo Xixian , Guo Lin , Dong Bin
Published: July 2021

The second near-infrared (NIR II) response photon up-conversion (UC) materials show great application prospects in the fields of biology and optical communication. However, it is still an enormous challenge to obtain efficient NIR II response materials. Herein, we developed a series of Er3+ doping ternary sulfides phosphors with highly efficient UC emissions under 1532 nm irradiation. Excitingly, β-NaYS2:Er3+ achieves a breakthrough visible UC efficiency as high as 6.13%, along with outstanding brightness, spectral stability of lights illumination and temperature. Such efficient UC dominates by excited state absorption process accompanied by the advantage of super long lifetimes of excited state levels of Er3+, instead of the well-recognized energy transfer UC between sensitizer and activator. NaYS2:Er3+ phosphors are further developed for high-performance underwater communication and a narrowband NIR photodetectors. Our findings breakthrough the traditional thinking of realizing efficient UC, and open up a novel frontier for developing NIR II response UC materials.
Application of Broccoli Residues to Soil can Suppress Verticillium Wilt of Cotton by Regulating the Bacterial Community Structure of the Rhizosphere
Authors: Zhao Weisong , Guo Qinggang , Li Shezeng , Lu Xiuyun , Wang Peipei , Dong Lihong , Zhang Xiaoyun , Su Zhenhe , Ma Ping
Published: July 2021

[Aims] Verticillium wilt (VW) of cotton was effectively controlled by application of broccoli residues (BR) to soil. Information regarding the variation in bacterial communities in rhizosphere of cotton cultivars with different VW resistance levels under BR treatment is still lacking and finally to provide guidance for screening effective biocontrol bacteria. [Methods] Real-time fluorescence quantitative PCR was used to determine the population of Verticillium dahliae, the effects of BR on the bacterial community structure in rhizosphere were determined by high-throughput sequencing technology. [Results] Results showed that control effects for susceptible cultivar (cv. EJ-1) and resistant cultivar (cv. J863) on VW after BR treatment were 51.76% and 86.15%, the population of V. dahliae decreased by 18.88% and 30.27%, respectively. High-throughput sequencing showed that ACE and Chao1 indices were increased by application of BR. Actinobacteria, Proteobacteria, Bacteroidetes, Gemmatimonadetes, Acidobacteria, and Firmicutes were the most dominant phyla, and relative abundances of these bacterial taxa significantly differed between cultivars. Additionally, Bacillus stably increased in rhizosphere following BR treatment. Redundancy analysis (RDA) showed that relative abundances of Bacillus, Lysobacter, Streptomyces, Rubrobacter, Gemmatimonas, Bryobacter and Nocardioides were correlated with occurrence of VW. Field experiments demonstrated that dressing cotton seeds with Bacillus subtilis NCD-2 could successfully reduce occurrence of VW, and control effects for EJ-1 and J863 were 35.26% and 31.02%, respectively. [Conclusions] The application of BR changed the bacterial community structure in cotton rhizosphere, decreased the population of V. dahliae in soil, and increased the abundance of beneficial microorganisms, thus significantly reducing the occurrence of VW.
Upregulated Serum Granulysin Levels in Women With Antiphospholipid Syndrome-Associated Recurrent Miscarriages Are Downregulated by Heparin Treatment
Authors: Ichikawa Tomoko , Negishi Yasuyuki , Kasano Sayuri , Yokote Ryoko , Yonezawa Mirei , Ouchi Nozomi , Kuwabara Yoshimitsu , Takeshita Toshiyuki
Published: July 2021

Background

Antiphospholipid antibody syndrome is the major cause of recurrent pregnancy loss (RPL) and associated with inflammation. Granulysin is a cytotoxic protein secreted by cytotoxic T cells, natural killer cells, and natural killer T cells that is present in abundance in the decidua. It activates innate and cellular immunity simultaneously, and also induces miscarriage. As a treatment, heparin is widely used for the patients with RPL, and exhibits the antithrombotic and anti-inflammatory activities, and angiogenesis.
Methods

We hypothesized that granulysin is an important factor in inducing miscarriage. Here, we evaluated the changes of serum granulysin level before and 1 week after the commencement of heparin treatment for the patients with RPL.
Results

The serum granulysin levels before heparin treatment were significantly higher in women who tested positive for one or more types of antiphospholipid antibody (2.75 ± 1.03 vs. 2.44 ± 0.69; P = 0.0341 by Welch’s t-test), particularly anti-phosphatidylethanolamine antibodies (IgG: 2.98 ± 1.09 vs. 2.51 ± 0.86; P = 0.0013, IgM: 2.85 ± 1.09 vs. 2.47 ± 0.77; P = 0.0024 by Welch’s t-test). After heparin treatment for 1 week, the serum granulysin levels were reduced significantly (P = 0.0017 by paired t-test). The miscarriage rate was significantly higher in women whose serum granulysin levels were not reduced by heparin treatment (P = 0.0086 by Fisher’s exact probability test).
Conclusions

These results suggest that heparin may reduce the incidence of miscarriages by suppressing the serum granulysin levels.
TopFuzz4SA: An Integrated Fuzzy Neural Network with Topic-aware Auto-encoding for Sentiment Analysis
Authors: Vo Tham
Published: July 2021

Recent advanced deep learning architectures, such as neural seq2seq, transformer, etc. have demonstrated remarkable improvements in multi-typed sentiment classification tasks. Even though recent transformer-based and seq2seq-based models have successfully enabled to capture rich-contextual information of texts, they are still lacking of attention on incorporating the global semantic information, such as topic, in order to sufficiently leverage the performance of downstream SA task. Moreover, emotional expressions of users are normally in forms of natural human-written textual data which might consist a lot of noise and ambiguity which impose great challenges on the processes of textual representation learning as well as sentiment polarity prediction. To meet these challenges, we propose a novel integrated fuzzy-neural architecture with a topic-driven textual representation learning approach for handling SA task, called as: TopFuzz4SA. Specifically, in the proposed TopFuzz4SA model, we first apply a topic-driven neural encoder-decoder architecture with the incorporation of latent topic embedding and attention mechanism to sufficiently learn both rich contextual and global semantic information of the given textual data. Then, the achieved rich semantic representations of texts are fed into a fused deep fuzzy neural network to effectively reduce the feature ambiguity and noise, forming the final textual representations for sentiment classification task. Extensive experiments in benchmark datasets demonstrate the effectiveness of our proposed TopFuzz4SA model in comparing with contemporary state-of-the-art baselines.
Oxidative Stress Is Involved In The Activation of NF-κB Signal Pathway And Immune Inflammatory Response In Grass Carp Gill Induced By Cypermethrin And/Or Sulfamethoxazole Exposure
Authors: Li Baoying , Wang Yu , Zhao Hongjing , Yin Kai , Liu Yachen , Wang Dongxu , Zong Hui , Xing Mingwei
Published: July 2021

At present, the concentration of environmental pollutants, such as pesticides and antibiotics exposed in environment, especially in aquatic environment is increasing. These contaminants are exposed through aquatic environment to fish and ultimately accumulate in humans. Research on environmental pollutants has exploded in the past two years. However, there are still few studies on the combined effects of pesticides and antibiotics on fish, especially on fish gills. A separate analysis of the toxic effects caused by an environmental pollutant cannot fully show the real situation. In this paper, cypermethrin (CMN) and sulfamethoxazole (SMZ) were analyzed and found that there was a strong correlation between the pathways affected by the first 30 genes regulated by CMN and SMZ respectively. Therefore, the toxic effects of CMN (0.651 μg/L) and/or SMZ (0.3 μg/L) on grass carp gill were studied in this paper. Histopathology, quantitative real-time PCR and other methods were used to detect the tissue morphology, oxidative stress level, inflammation and apoptosis-related indicators of the fish gills after exposure 42 days. It was found that compared with the single exposure (SMZ/CMN) group, the combined exposure (MIX) group had a more pronounced oxidative stress index imbalance. At the same time, nuclear factor-κB (NF-κB) signal pathway was activated and immuno-inflammatory reaction appeared in MIX group. This study reveals the harm of CMN and SMZ to fish, and provides a reference and basis for the rational use of pesticides and antibiotics.
Lamellar thickness in semicrystalline polymers as a result of the competition between crystal growth and intracrystalline chain dynamics
Authors: Schulz Martha , Schäfer Mareen , Saalwächter Kay , Thurn-Albrecht Thomas
Published: July 2021

The non-equilibrium thickness of lamellar crystals in semicrystalline polymers varies largely between different polymer systems and depends on the crystallization temperature Tc. There is currently no consensus on the mechanism of thickness selection. Previous work has highlighted the decisive role of intracrystalline chain dynamics (ICD) in special cases, but a systematic dependence of lamellar thickness on relevant timescales such as that of ICD and stem attachment has not yet been established. Studying the morphology by small-angle X-ray scattering and the two timescales by NMR methods and polarization microscopy, we here present data on poly(oxymethylene), a case with comparably slow ICD. It fills the gap between previously studied cases of absent and fast ICD, enabling us to establish for the first time a quantitative dependence of lamellar thickness on the competition between the noted timescales.
Ultrastructural Analysis of Apoptosis Induced By Zinc Oxide Nanosphere in Human Hepatoma Huh7 Through Mitochondria Dysfunction
Authors: Hassan Amr , Abuamara Tamer M.M. , Matar Emadeldin R. , Aboulthana Wael M. , baz Hatim A. El- , Zoair Mohammad A. , Mohamed Aly Fahmy , Maksoud Ahmed I. Abd El
Published: July 2021

The efficiently of hepatocellular carcinoma therapy predominantly depends on advancement of nanomedicine. Zinc oxide nanostructure is promising material in nanomdicine field due to their unique properties. Zinc oxide Nanosphere (ZnO Ns) was fabricated with a size 50 nm diameter by a developed Sol-gel approach, using non-toxic biotemplate yeast extract. The physicochemical properties of zinc oxide nanosphere were estimated by Fourier-transform infrared spectrum (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), and transmission electron microscope (TEM). Liberated zinc ions released from the zinc oxide nanosphere suspended medium was determined by ICP-AS. The viability was tested by using HuH7 and Vero cells.ZnO nanosphere was more effectively on cell line than released Zn ions. The cell cycle arrested at G1/S. Also, the apoptosis assay by using Annexin-V/PI showed that apoptosis of HuH7 by ZnO nanosphere is concentration and time-dependent. The mechanism of apoptosis was evaluated via using techniques such as RT-PCR and flow cytometry. The results revealed significance up-regulated of Bax, P53, and Cytochrome C, while a Bcl2 results displayed significance down-regulated.Caspase 3 assay results showed that the apoptosis mechanism was intrinsic and extrinsic pathways. Also, ZnO nanosphere and free Zn+2 ions induced oxidative stress via increasing reactive oxygen species (ROS) and lipid peroxidation. The ultrastructural analysis of HuH7 cell was occurred by TEM.Transmission electron microscope analysis of HuH7 after treated with ZnO nanosphere at different times revealed a chromatin condensation of the nuclear periphery fragmentation appearance. Interestingly, the apoptosis of HuH7 cells induced by Zinc oxide nanosphere, showed the canonical ultrastructure features of apoptotic nuclei, and fragmented by budding. Furthermore, There were many vacuoles that filled in the cytoplasm, majority lipid droplets, which resembling those observed in foamy cells, and vesicles with intact membranes, which were recognized as swollen mitochondria.
Accompanying the Prostate Cancer Patient Pathway: Evaluation of Novel Clinical Decision Support Software
Authors: Henkel Maurice , Horn Tobias , Leboutte Francois , Trotsenko Pawel , Dugas Sarah G. , Sutter Sarah Ursula , Ficht Georg , Engesser Christian , Matthias Marc , Stalder Aurelien F. , Ebbing Jan , Cornford Philip , Seifert Helge , Stieltjes Bram , Wetterauer Christian
Published: July 2021

Introduction Physicians spend more than half of their workday interacting with health information systems to care for their patients. Effective data management that provides physicians with comprehensive patient information from various information systems is required to ensure high quality clinical decision making.Objectives We evaluated the impact of a novel, CE-certified clinical decision support tool on physician’s effectiveness and satisfaction in the clinical decision-making process.Methods Using pre-therapeutic prostate cancer management cases, we compared physician’s expenditure of time, data quality, and user satisfaction in the decision-making process comparing the current standard with the software. Ten urologists from our department conducted the diagnostic work-up to the treatment decision for a total of 10 patients using both approaches.Results A significant reduction in the physician’s expenditure of time for the decision-making process by -59.9 % (p < 0,001) was found using the software. System usage showed a high positive effect on evaluated data quality parameters completeness (Cohen's d of 2.36), format (6.15), understandability (2.64), as well as user satisfaction (4.94).Conclusion The software demonstrated that effective data management can improve physician’s effectiveness and satisfaction in the clinical decision-making process. Further development is needed to map more complex patient pathways, such as the follow-up treatment of prostate cancer.
Alactic Base Excess, New Potential Marker Associated for Circulatory Stress Due to Hemodialysis, a Pilot Study
Authors: Aguilera Angelica Luevanos , Diaz Juan Lopez , Ramos Jose Sosa , Nobara Texar Pereyra
Published: July 2021

Indroduction: Circulatory stress increases mortality in patients with chronic kidney disease in renal replacement therapy by hemodialysis, the measurement of central venous saturation has been proposed as a useful tool for diagnosis but with limitations. We wanted to evaluate a new marker, the alactic base excess, to be applied in all types of hemodialysis patients to help diagnose this clinical condition.Methodology: An observational, analytical, prospective and longitudinal study was carried out in hemodialysis of the Instituto Mexicano del Seguro Social, in León, Guanajuato from May 2020 to June 2021 by determining the alactic base excess. The association of alactic base excess as a marker of circulatory stress in hemodialysis was proposed as a primary end point and mortality at 12 months was evaluated as a secondary end point.Results: An inverse association was found between the alactic base excess with the initial pH (r= -0.303, p= <0.05) and the final lactate (r= -0.297, p= <0.05), in addition to bicarbonate (r= 0.593, p= <0.05) and central venous saturation variability (r= 0.304, p= <0.05). In the analysis by subgroups, both lower tertiles had a higher risk of presenting the adverse event (HR= 0.817, [95% CI 0.21 to 3.05], p= 0.763). No association of mortality was found with the first (HR= 0.95, [95% CI= 0.73 to 1.2], p= 0.687) or final determination (HR= 1, [95% CI= 0.758 to 1.3], p= 0.99).Discussion: In this study we found that the alactic base excess proposed to diagnostic different types of acidosis is capable of identifying small changes related to circulatory stress, regardless of the chronicity of kidney failure, hemodynamic status or hemoglobin concentration, but not related to mortality.Conclusions: Alactic base excess is potentially useful to evaluate circulatory stress in conjunction with other tissue hypoperfusion markers, however it would be necessary to expand the sample size and introduce therapeutic variables to determine its clinical impact.
Investigation on the Anisotropy of Mechanical Properties and Brittleness Characteristics of Deep Laminated Sandstones
Authors: Zhai Mingyang , Wang Zenglin , Zhang Liaoyuan , Li Aishan , Zhang Zilin , Zheng Bintao , Huang Bo , Li Lianchong
Published: July 2021

Rock brittleness is a crucial mechanical property and essential for fracability evaluation and fracturing scheme design in unconventional reservoirs. However, the influence of inherent anisotropy on deep laminated sandstone’s mechanical properties and brittleness characteristics is rarely investigated. The energy transformation and damage evolution reflected by complete stress-strain curves are analyzed during the entire process of rock rupture under compressions. A new brittleness index is established based on energy evolution during sandstone failure. Its advantages involve comprehensively considering the energy transformation characteristics at both pre-peak and post-peak stages and the capability to characterize the effect of confining pressure and bedding plane (BP) geometry on sandstone brittleness. The triaxial compression tests on sandstones are conducted to validate the reliability and accuracy of the new brittleness index. Numerical simulations are then performed to further investigate the manner in which BP angle, BP density, and confining pressure control the brittleness anisotropy of deep laminated sandstones based on the finite element method. Then the acoustic emission (AE) characteristics of anisotropic sandstone and correlations between AE mode and brittleness index are discussed. The results indicated that the anisotropy of mechanical properties and brittleness of deep laminated sandstones were significantly affected by BP angle, BP density, and confining pressure. With the increase of BP angle, the brittleness index of deep laminated sandstone decreases first and then increases, showing a U-shape variation law, whose maximum and minimum values are obtained at φ =0° and φ =45°, respectively. The AE characteristics were closely related to rock brittleness, which was jointly controlled by BP geometry and confining pressure. The results provide a basis for the brittleness and fracability evaluation and optimum hydraulic fracturing design in deep laminated sandstones.
Predictors of Pathologic Complete Response in Patients With Residual Flat Mucosal Lesions After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Case Control Study
Authors: Li Chang-Long , Guan Zhen , Zhao Yi , Sun Ting-Ting , Li Zhong-Wu , Wang Wei-Hu , Wang Lin , Wu Ai-Wen
Published: July 2021

Background:

Accurate prediction of tumor response to neoadjuvant chemoradiotherapy (nCRT) remains challenging. There are few studies on pathologic complete response (ypCR) prediction in patients with residual flat mucosal lesions after treatment. This study aimed to identify variables for predicting the ypCR in patients with residual flat mucosal lesions after nCRT for locally advanced rectal cancer (LARC).
Methods:

Patients with residual flat mucosal lesions after nCRT who underwent radical resection between 2009 and 2015 were retrospectively collected through the LARC database at Peking University Cancer Hospital. Univariate and multivariate analyses of the association between clinicopathological factors and ypCR were performed, and a nomogram was constructed by incorporating the significant predictors.
Results:

Out of the 246 patients with residual flat mucosal lesions that were included in the final analysis, 56 (22.8%) had ypCR. Univariate and multivariate analyses showed that posttreatment serum carcinoembryonic antigen (post-nCRT CEA) ≤ 5 ng/ml, magnetic resonance-tumor regression grade (MR-TRG) 1 to 3, and residual mucosal lesion depth = 0 mm were significantly associated with a higher rate of ypCR. A nomogram was developed with a C-index of 0.735, and the calibration curve showed that the nomogram model had good predictive consistency.
Conclusion:

Post-nCRT CEA ≤ 5 ng/ml, MR-TRG 1 to 3, and residual mucosal lesion depth = 0 mm were predictive factors for ypCR in LARC patients with residual flat mucosal lesions after nCRT. We believe that mucosal re-evaluation before surgery is important as it may contribute to decision-making and facilitating non-operative management or organ preservation.
Exploring Long Non-coding RNA Potential Markers for Prognosis Risk based on Double Hormone Receptor Positive Breast Cancer CeRNA Network
Authors: Huang Qi , Peng Yao , Wu Jingjing , Li Na
Published: July 2021

Purpose: The aim of this study is to search for key long non-coding RNA (lncRNAs) able to influence the prognosis of double hormone receptor positive (ER+PR+) breast cancer by constructing a competing endogenous RNA (ceRNA) topology network of RNA-seq data and miRNA-seq data. Materials and methods: Based on The Cancer Genome Atlas (TCGA), we downloaded RNA-seq data and miRNA-seq data of ER+PR+ breast cancer and obtained lncRNA-miRNA relationship pairs by comparing with the data in moRcode database. MiRDB, miRTarBase and TargetScan databases were used to predict target genes, and thereby gaining miRNA-mRNA relationship pairs. The ceRNA network was constructed using Cytoscape, then functional enrichment analysis was performed. Cox survival analysis was carried out to explore the potential prognostic lncRNAs.Results: A ceRNA topology network was constructed and six lncRNAs, PSORS1C3, AC010536.2, IQCF5-AS1, AL021707.1, FGD5-AS1, and PART1, were found to be mostly associated with the survival of ER+PR+ breast cancer. Conclusion: Six lncRNAs with prognostic significance were identified in ER+PR+ breast cancer, providing new ideas for the diagnose and treatment of this subtype.
China’s Successful Recruitment of Healthcare Professionals to the Worst-hit City: A Lesson Learn
Authors: Zhu Pingting , Liu Xinyi , Wu Qiwei , Loke Jennifer , Lim Deborah , Xu Huiwen
Published: July 2021

Background The outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan has led Chinese health authorities to recruiting medical doctors and nurses from the least affected areas to provide care to the infected patients in Wuhan. The current study is part of a larger study where we took further steps to explain some plausible reasons for the experiences.Methods We used Interpretative Phenomenological Analysis (IPA) to understand the subjective experiences as well as the reasons for these experiences amongst the medical doctors and nurses who had travelled form the least affected part of China to render help during Wuhan’s outbreak. Using purposive and snowball sampling, healthcare professionals were recruited from three major hospitals in Jiangsu province. Basing on the participants’ choice of venue, semi-structured interviews were conducted from 1st September to 14th November 2020 in face-to-face contexts. ResultsTen nurses and four doctors provided their informed consent for the study. The primary superordinate theme recounted how the social identity and individual’s needs were challenged by the individual’s professional ethics.ConclusionsCOVID-19 not only presents significant risks to the health of healthcare professionals, it further challenges their emotional and psychosocial wellbeing. Care should be taken in allocating support and help, with careful deployment of professional values and beliefs, so that any human resources as precious as medical doctors and nurses can be protected.
Reporting of Patient And Public Involvement (PPI) In Clinical Trials Published In Three Leading Nursing Science Journals: A Scientiometric Study
Authors: Gray Richard , Brasier Catherine , Ng Ashley H
Published: July 2021

Background: Patient and Public Involvement (PPI) in identifying research questions, designing trials, and collecting, interpreting, and publishing results may positively affect the relevance, quality and impact of research. The extent of patient and public involvement in nursing clinical trials has not been previously studied. Methods: A Scientiometric study of PPI in clinical trials published in three leading nursing science journals. Randomised controlled clinical trials published in the International Journal of Nursing Studies, the Journal of Clinical Nursing, and the Journal of Advanced Nursing between January and April 2021 were identified by searching the SCOPUS database. Journal author guidelines were also review. Data were extracted against the five items of the Guidance for Reporting Involvement of Patients and the Public (GRIPP2) reporting checklist. Results: None of the journals required authors to include a patient and public involvement statement in submitted papers or to thank participants in the acknowledgement section of the paper. We included 23 randomised controlled clinical trials, of which half were conducted in Europe and 12 were supported by external grants. Authors thanked participants in the acknowledgement section often (43%) trials. There was no statement or evidence of patient and public involvement in any of the included trials.Conclusion: There was no evidence of PPI in trials published in nursing science journals. Researchers, funders, and journals need to collaborate to change cultural expectations to ensure that PPI is an emended part of clinical research.
Cytokine Profiles in the Detection of Severe Lung Involvement in Hospitalized Patients With COVID-19: the IL-8 – IL-32 axis
Authors: BERGANTINI LAURA , d’Alessandro Miriana , Cameli Paolo , Otranto Ambra , Luzzi Simona , Bianchi Francesco , Bargagli Elena
Published: July 2021

Coronavirus disease 2019 (COVID-19) is an infectious respiratory disorder caused by a new coronavirus called SARS-CoV-2. The pathophysiology of severe COVID-19 is associated with a “cytokine storm”, characterized by anomalous release of various pro-inflammatory cytokines which contribute to alveolar exudation and lung damage. Overproduction of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF-α and low of expression IFN-γ have been found in severe COVID-19 patients. The mechanism by which IL-32 exerts its signalling properties is unclear. IL-32 is a key modulator in the pathogenesis of various clinical conditions and is mostly induced by IL-8. IL-32 modulates important inflammatory pathways (including TNF-α, IL-6 and IL-1b), contributing to the pathogenesis of inflammatory diseases. A total of 64 COVID-19 patients, stratifying as mild moderate and severe patients and 27 healthy controls were consecutively enrolled in the study. Serum concentrations of biomarkers including IL-1β, IL-10, IFN-γ, TNF-α and IL-6 were quantified by bead-based multiplex analysis and Serum concentration of IL-8 and IL-32 were determined by enzyme-linked immunosorbent assay (ELISA) kits. Interestingly, among the blood parameters, neutrophil and lymphocyte counts were significantly lower in severe COVID-19 patients than in the other, on the contrary, CRP was significantly higher in severe patients than in other groups. The cytokines that best distinguished controls from COVID-19 patients were IL-8 and IL-32.The best model performance for severe group was obtained by the combination of IL-32, IL-6 and IFN-γ, and serum concentrations of CRP increased model performance, showing AUC=0.83. New insights into the cytokine storm in COVID-19 patients, highlighting specific cytokine signatures among patients with different severity of infection.
Exploiting Renewable Energy and UPS Systems to Reduce Power Consumption in Data Centers
Authors: Peng Xiaopu , Bhattacharya Tathagata , Cao Ting , Mao Jianzhou , Tekreeti Taha , Qin Xiao
Published: July 2021

To develop environmental friendly and energy-efficient data centers, it is prudent to leverage on-site renewable sources like solar and wind. Data centers deploy distributed UPS systems to improve efficiency, scalability, and reliability of UPS systems, thereby handling the intermittent nature of renewable energy. We propose a renewableenergy manager called REDUX to (1) offer a smart way of managing energy supply of data centers powered by grid and renewable energy and (2) maintain a desirable balance between energy cost and system performance. To achieve this overarching objective, REDUX judiciously orchestrates distribute UPS devices (i.e., recharge or discharge) to allocate energy resources when (1) grid price is at low or high states or (2) renewable energy generation is at a low or fluctuate level. REDUX not only guarantees the stable operation of daily workload conditions, but also cuts back the energy cost of data centers by improving power resource utilization. Compared with the existing strategies, REDUX demonstrates a prominent capability of mitigating average peak workload and boosting renewable-energy utilization.
Real-Time Quantitative Assessment of Transport Induced Greenhouse Gases Emissions Profile in Lagos, Nigeria.
Authors: Okafor Chinenye Lilian , Ahove Michael A , Odewumi Samuel G , MacCracken Michael , Odesanya Babatunde
Published: July 2021

Over the years, scientists have established that when fossil fuels are burnt, the resultant effect is pollution of the ambient air with pollutants such as carbon monoxide (CO), methane (CH4), oxides of nitrogen (NOX), oxides of sulfur (SOX), volatile organic hydrocarbons and particulate matter and atmospheric greenhouse gases such as carbon dioxide (CO2) and methane (CH4) and heat-warming or cooling aerosols such as black soot and sulfate aerosols, respectively. These pollutants become present in the atmosphere at a concentration that can affect human health, the environment, and even society as a whole. Since around 1750, human activities have increased the concentration of CO2 and other greenhouse gases in the atmosphere by many tens of percent over the last two centuries. The Federal Government of Nigeria, through the office of National Environmental Standards and Regulation Enforcement Agency (NESREA), established guidelines and standards (limits) for the abatement and control of all forms of pollution through the establishment of Nigerian Ambient Air Quality Standards (NAAQS). Different studies on the impacts of urban road transportation on ambient air quality carried out by scholars have suggested that most pollutant gases in the atmosphere are traffic-related as a result of the combustion of petroleum-based products like gasoline and diesel in internal combustion engines. This study deployed a quantitative technique to determine the emissions profile of transport nodes in Ikeja, Lagos through the use of AEROQUAL 500s portable air monitoring equipment. Results showed that CO, CO2 and CH4 emissions were highest during the AM peak and PM peak periods and lower during the inter-peak period, while NOx emissions were relatively stable throughout the time periods.