bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of Past and Future Mass Balance of Glaciers of Sikkim Himalaya using Energy Balance Modelling Approach and Regional Climatic Projections
Authors: Aggarwal Anubha , Mandal Anubha
Published: September 2021

In this study, the mass balance of Sikkim Himalayan glaciers is computed by the energy balance modeling approach using REMO and APHRODITE data. According to the present work, the glaciers show a mass balance of ~0, +0.31 and –0.32 m w. e. yr–1 for time periods 1981-1990, 1991-2000 and 2001-2005. To investigate the possible changes in the near future (2006-2049) and far future (2070-2099), REMO data under different representation concentration pathway scenarios 2.6, 4.5 and 8.5 are also analysed. For the time period 2006–2100, RCP2.6, RCP4.5 and RCP8.5 give an average mass balance of -0.75 m w. e. yr–1, -1.04 m w. e. yr–1 and -1.4 m w. e. yr–1, respectively. The results are comparable to other studies. This study is one of the few studies carried out to estimate the mass balance of glaciers using only climate model data.
Hydro-meteorological Correlations of Himalayan Glaciers: A Review
Authors: Singh Virendra Bahadur , Ramanathan AL. , Kumar Pramod
Published: September 2021

This review manuscript addresses hydro-meteorological correlations of various glaciers situated in the Himalayan region. Meteorological parameters influence the discharge pattern of the glacier. A strong correlation has been observed between discharge and air temperature of the studied Himalayan glaciers. Whereas, other meteorological parameters such as wind speed and wind direction etc. were not significantly correlated with the meltwater runoff of different glaciers in this region. In general, variability (Cv) in discharge from the various Himalayan glaciers such as Chhota Shigri and Gangotri glaciers follow the variability (Cv) in the temperature of these glaciers. Maximum variability (Cv) in meltwater runoff from the Chhota Shigri glacier has been reported in the month of September, which might be due to the fast decline in stream runoff and air temperature of the study area during the month of September. A strong relationship has been observed between suspended sediment concentration and temperature of the majority of studied Himalayan glaciers. Such type of result shows that the suspended sediment concentration in the glacial meltwater has increased with rising air temperature in this region.
Using an iPad job coaching intervention to enhance food preparation skills for individuals with developmental disabilities
Authors: Morse Kerri P. , Dukes Charles , Brady Michael P. , Frain Michael , Duffy Mary Lou
Published: September 2021

BACKGROUND: Technology is portable, affordable, and accessible, making it a viable support option for people with disabilities in the workplace. In the past, many supported employment programs relied on natural and paid job coaching supports with little to no use of technology. OBJECTIVE: The purpose of this two-experiment study was to investigate the use of a portable multimedia device to teach seven young adults with developmental disabilities to increase independence and decrease dependence on coaching prompts while performing a food preparation task. METHODS: Participants adhered to an industry specific protocol while using an application on an iPad that provided audio and video prompts. A multiple baseline across participants was used to show effects of the intervention on task performance and reliance on prompts. RESULTS: All participants were able to follow directions delivered to complete tasks accurately, while reducing the need for simultaneous coaching prompts. Maintenance probes were added to Study 2, and for two of three participants, newly acquired skills were maintained for eight weeks. CONCLUSIONS: Results from both studies indicated that using the iPad application to video model tasks was effective in improving and maintaining accurate skill performance, while reducing the need for prompts.
Proses Pembuatan Komposit Matriks Logam Al5Cu4Mg/Al2O3(p) dengan Metode Pengadukan dan Tempa
Authors: Romijarso Toni Bambang , Subagja Rudi , Priadi Dedi
Published: September 2021

AbstrakKomposit Matriks Logam (KML) merupakan salah satu material yang banyak digunakan di industri manufaktur  terutama yang berbasis alumunium,  karena logam ini mempunyai berat jenis yang rendah. Pada saat ini pembuatan KML bermatriks alumunium dengan penguat Al2O3 sudah banyak dibuat dan digunakan di industri. Proses pembuatan KML di Indonesia merupakan hal yang baru-baru ini ramai diminati, meskipun penelitian awal sudah dilakukan jauh sebelumnya. Faktor penting pada pembuatan KML adalah menghidari adanya keropos atau adanya porositas pada hasil produk. Oleh karena itu, pada percobaan ini setelah dilakukan proses pengadukan dilanjutkan dengan proses tempa untuk mengurangi adanya porositas tersebut. Bahan yang digunakan sebagai matriks adalah Al-5%Cu-4%Mg dimana Mg sebagai wetting agent, sedangkan penguat yang digunakan adalah 5 dan 10% Vf Al2O3. Pengujian mekanik yang dilakukan antara lain uji tarik, kekerasan dan keausan, sedangkan pengujian fisik, yaitu: metalografi, berat jenis, porositas, SEM/EDS dan XRD, untuk melihat fasa dan senyawa baru. Hasil pengujian menunjukkan dengan adanya penguat Al2O3 terjadi kenaikkan sifat mekanik antara lain dengan naiknya angka kekerasan dan naiknya nilai ketahanan aus. AbstractThe Metal Matrix Composite (MMCs) is one of the widely used materials  in the manufacturing industry, especially those based on aluminum, because this metal has low specific gravity. At this time, aluminum matrix KML with Al2O3 reinforcement has been widely made and used in industry. The process of making MMCs in Indonesia have just developed recently, even tough the previous research have been conducted for a long time. The important factor in making MMCs in to prevent the porosity at it’s product. This is the reason why we conduct a forging process after the agitation process. The materials used as matrix is Al-5%Cu-4%Mg where Mg is the wetting agent, while the reinforcement used is 5 and 10% Vf Al2O3. Mechanical tests include: tensile, hardness and wear tests, while physical tests: metallography, specific gravity, porosity, SEM/EDS and XRD, to see new phases and compounds. With the addition of Al2O3 reinforcement there is an increase in mechanical properties, among others, by increasing the number of hardness and increasing wear resistance.
Educación continua: indicaciones para el aprendizaje a distancia de las ciencias biológicas en la educación primaria y secundaria
Authors: Dendasck Carla Viana , Oliveira Euzébio de , Fecury Amanda Alves , Dias Claudio Alberto Gellis de Mattos
Published: September 2021

Aunque las discusiones sobre la posibilidad de la educación en línea en la escuela primaria y secundaria en Brasil han entrado en la estela del debate teórico, todavía hay una gran resistencia. Sin embargo, el contexto de pandemia no trajo alternativas, llevando a miles de estudiantes al aislamiento social durante más de un año. Este contexto provocó que los maestros de primaria y secundaria se adaptaran a las nuevas tecnologías, demostrando así la necesidad de prepararse para trabajar en la enseñanza de aprendizaje remoto. La pregunta guía de este material fue: ¿Cómo pueden prepararse los maestros de ciencias de la vida y qué herramientas básicas deben conocer para preparar sus clases en línea? Así, el objetivo general era llevar a cabo indicaciones que los profesores deberían conocer para preparar sus clases online. La metodología adoptada fue exploratoria a través de la revisión de la literatura. Los principales indicios fueron que los docentes necesitan buscar contenidos diversificados en la preparación de las clases para adoptar estrategias de motivación con sus alumnos, adoptando cuidados con el tema del lenguaje, el audio y la luz en la producción de las clases. Finalmente, le dependerá al docente reconocer las diversas herramientas y recursos como: Youtube, Instagram, Películas, Juegos, y otras subvenciones, para que haya una aproximación entre la enseñanza de la biología y la realidad del alumno.
Число случаев гепатита, приобретенного в результате несчастных случаев на производстве в Бразилии в период с 2009 по 2018 год
Authors: Almeida Naara Perdigão Cota de , Lima Júnior Idelbrando Araújo , Azevedo Lucas do Rêgo Góes , Martins Romulo Maia , Magalhães Gustavo Aurélio Linhares , Dias Claudio Alberto Gellis de Mattos , Araújo Maria Helena Mendonça de , Oliveira Euzébio de , Dendasck Carla Viana , Fecury Amanda Alves
Published: September 2021

Вирусный гепатит является серьезной проблемой общественного здравоохранения в мире и в Бразилии. Это заболевания, подлежащие обязательному уведомлению, учрежденные Министерством здравоохранения Бразилии (MS). Записи о пострадавших лицах должны вестись в Информационной системе по подлежащим уведомлению болезнях (SINAN), которая должна уведомлять обо всех вероятных случаях, подтвержденных и вспышках. Целью этой работы является количественная оценка числа случаев гепатита, приобретенного в результате несчастных случаев на производстве в Бразилии в период с 2009 по 2018 год. Именно исследование представляет собой ретроспективный наблюдательный количественный анализ исследуемых эпидемиологических данных. В этом смысле исследования проводились в базах данных национального портала DATASUS (https://datasus.saude.gov.br/). Существует эффективный вклад несчастных случаев на производстве в нынешние показатели заболеваемости вирусным гепатитом в Бразилии, а также в снижение качества жизни работников, особенно в области здравоохранения. Несоответствия между эпидемиологическими данными, зафиксированными в SINAN, и исследованиями в литературе могут свидетельствовать о наличии занижения отчетности. Из-за относительной скудности и противоречия исследований не существует устоявшегося профиля загрязнения в службах здравоохранения, и существует необходимость в дальнейших исследованиях по этому вопросу.
Непрерывное образование: показания к дистанционному изучению биологических наук в начальном и среднем образовании
Authors: Dendasck Carla Viana , Oliveira Euzébio de , Fecury Amanda Alves , Dias Claudio Alberto Gellis de Mattos
Published: September 2021

Хотя дискуссии о возможности онлайн-образования в начальной и старшей школе в Бразилии вступили в волну теоретических дебатов, все еще существует большое сопротивление. Однако пандемический контекст не принес альтернатив, что привело тысячи студентов к социальной изоляции более чем на год. Этот контекст заставил учителей начальных и средних школ адаптироваться к новым технологиям, тем самым продемонстрировав необходимость подготовки к работе в дистанционном обучении. Вопрос руководства этого материала заключался в том, как могут подготовиться учителя наук о жизни и какие основные инструменты они должны знать, чтобы подготовить свои онлайн-классы? Таким образом, общая цель состояла в том, чтобы выполнить указания, которые учителя должны знать для подготовки своих онлайн-классов. Принятая методология была исследовательской путем обзора литературы. Основные признаки заключались в том, что учителям необходимо искать разнообразное содержание при подготовке классов, чтобы принять стратегии мотивации со своими учениками, проявляя осторожность в вопросе языка, звука и света при производстве классов. Наконец, учитель должен будет распознать различные инструменты и ресурсы, такие как: Youtube, Instagram, Фильмы, Игры и другие субсидии, чтобы было приближение между преподаванием биологии и реальностью ученика.
КОМПАНІЇ-ЄДИНОРОГИ В МІЖНАРОДНОМУ БІЗНЕСІ: РЕГІОНАЛЬНО-ГАЛУЗЕВИЙ АСПЕКТ
Authors: Галахова Тетяна , Євдоченко Олена , Кислицина Ольга
Published: September 2021

Стаття присвячена дослідженню сутності та ключових особливостей компаній-єдинорогів - інноваційних стартапів, вартість яких складає 1 млрд. дол. США і більше. В статті підкреслено, що компанії - єдинороги - це компанії, які не тільки відповідають кількісній оцінці в 1 мільярд доларів, але й мають такі характеристики як трансформаційний галузевий корпоративний вплив, значний інноваційно-креативний та соціокультурний вклад у глобальний бізнес-розвиток у довгостроковій перспективі. Зважаючи на зміни глобального бізнес-середовища, авторами виділено основні характеристики компаній-єдинорогів сьогодні: підривні інновації, орієнтація на кінцевого споживача (В2С), суттєва зміна технологічної парадигми, заснована на комісії модель заробітку, найпопулярніший ринок – ритейл та електронна комерція. За результатами регіонально-секторального аналізу визначено, що більшість єдинорогів походить з США та Китаю та базується у високо інтегрованих містах категорії Alpha та Beta; суттєво превалює сектор фінтех, програмного забезпечення та ІТ-послуг, електронної комерції. В статті також узагальнено ключові трансформаційні виклики для розвитку компаній-єдинорогів у часи пандемії Covid-19: споживання з дому, роботу з дому та навчання з дому.
ДОХОДИ І ЯКІСТЬ ЖИТТЯ НАСЕЛЕННЯ УКРАЇНИ: СУЧАСНИЙ СТАН
Authors: Андрейцева Ірина
Published: September 2021

У статті узагальнено поняття «якість життя населення». Досліджено сучасний стан якості життя населення України. Проведено структурно-динамічний аналіз впливу доходів населення на якість життя. Виявлено переважання в структурі доходів населення двох джерел: соціальної допомоги і заробітної плати. Найвищі заробітки спостерігаються серед працівників фінансової сфери, промисловості, державного управління, інформації та телекомунікації. Встановлено значні диспропорції величини заробітків, зумовлені територіальними особливостями ринків праці. Виявлено існування гендерної нерівності щодо заробітних плат в країні. Серед населення країни виявлено значний відсоток жителів з середньодушовим доходом, нижчим прожиткового мінімуму. В сукупних витратах домогосподарств країни переважають витрати на харчування, оплату житла, комунальних послуг. Зроблено висновок про взаємозалежність якості трудового потенціалу і якості життя населення України.
Evaluation of Anti-Retroviral Drugs Effects on Liver Function Tests of HIV Infected Individuals
Authors: Olayonwa Damilare , Oyedeji Samuel
Published: September 2021

The Human Immunodeficiency Virus (HIV) continues to be a major global public health issue, having claimed more than 35 million lives so far. Antiretroviral therapy, the drug used to treat HIV patients, had been reported to have an adverse effect on patients’ livers. Therefore, this research aims to assess the parameters for measuring liver injury of HIV patients undergoing antiretroviral therapy in Owo and to determine the patients' vulnerability to liver injury. The study sample was divided into five groups comprising Control groups and groups with 6 months, 1 year, 3 years and 5 years’ periods of administration of an antiretroviral drug. Serum was separated from their blood and values of ALT, ALP and BILT were determined. The results of profiling the patients based on values ALT, ALP and BILT indicated that 73%, 71% and 59% of the patients are within the reference range of the parameters, respectively. Further analysis of the percentage of patients likely to have liver diseases indicated that only 3.2% are prone to liver injury. The results of the One-way Analysis of Variance of the mean values of the groups on ALT, ALP and BILT indicated differences in mean values of the groups.  It is suggested that a longitudinal study should be carried out to determine the effect of seasonal variation in the value of the studied parameters. It is also suggested that a wider interval of the period for the groups should be used in the future to determine whether there will be a relationship between the period of administration of the drug and the parameters.
Restaging Bronislava Nijinska’s Les Noces: Multimodal Interdisciplinary Curriculum in the Performing Arts
Authors: Katz Rizzo Laura
Published: September 2021

In this article I will discuss "Performance-As-Research," as a method of pedagogy, an approach to learning and problem solving, as a practice of inquiry and of making meaning in the performing arts, and as a conduit for students to develop physical, cognitive and affective proficiencies; in the context of a first year undergraduate dance repertory course. Over the past academic year, I have begun to collaborate with entering Bachelor of Fine Arts Dance majors at Temple University (where I am an assistant professor) to restage and perform Les Noces, (French; English: The Wedding; Russian: Свадебка, Svadebka), a ballet and orchestral concert work composed by Igor Stravinsky for percussion, pianists, chorus, and vocal soloists. Stravinsky subtitled the work "Choreographed Scenes with Music and Voices." The ballet, commissioned by Serge Diaghilev for the Ballets Russes, was choreographed by Bronislava Nijinska and premiered in Paris in 1923. In my Repertory I course, the students and I have worked together to collaboratively craft a creative reimagining of the original work. This article will describe that process, and demonstrate the multiple avenues for teaching and learning that Performance-As-Research opens up in the pedagogical context of the higher education performing arts curriculum.
Interactive Performance and Simulation Learning
Authors: Percival Kevin , Jimenez Olivia
Published: September 2021

Over the course of 2018 - 2019, interactive experience design company, (ix)plore Lab, created three simulation-based learning programs for the Travis County Reentry Employment Services (RES) training in Austin, Texas. Participants, most of whom were from organizations that assist formerly incarcerated individuals during the reentry process, attended workshops focused on client-based practices. Specifically, they learned techniques for better conducting informal assessments and motivational interviewing methods they could utilize in their work. Each workshop culminated in an interview with a fictional client, played by an actor. The team wished to improve upon existing live simulation models in several ways. First, by creating a method to provide immediate feedback to learners. Second, by increasing the simulations adaptability so it could adjust to each individual learner. Lastly, the simulation needed to have a high degree of emotional fidelity. To achieve these, (ix)plore Lab designed the programs by integrating techniques from interactive theater performance with existing simulation practices to effectively target specific skills for development. This article provides an overview of the techniques involved and adjustments made to focus on soft skill development, and documents three simulation-based learning programs that took place over the course of 2018 - 2019, highlighting developments made with each iteration. The training program documented in this paper was created without monetary compensation. In lieu of payment, the organizers of RES allowed (ix)plore Lab to collect feedback from learners and to use the training as a laboratory for workshopping this simulation-based learning model.
‘Beware The Word'
Authors: Shannon Jacquelyn
Published: September 2021

This paper considers the potential of utilizing ethnotheatre methods to investigate the experiences of butoh artists and practitioners as they struggle to verbalize the dance of the ineffable. While an unlikely approach, ethnotheatre-based research may offer an alternative methodology for grappling with the ineffable and the inarticulate in performance as an intermediary research process capable of not only attending to but foregrounding both language and the places where language fails through and of the body, utilizing language to foreground its limits. Through the labor of creating a script for performance, it offers a method of textual engagement within movement practice, one that gives data a body through which to ‘speak’ or express meaning. For the purposes of butoh research, its formal processes allow us to bring the silences and struggles with language into greater relief, spotlighting them, in a performance context. As an arts-based research methodological thought experiment, this paper seeks to demonstrate how taking an ethnotheatre approach to butoh research may provide captivating insight into the art of butoh, as well as yield a different kind of evidence of or living testimony to the operative force of language and the creative possibilities of failure.
Book Review: Theatre and Performance in the Neoliberal University edited by Kim Solga
Authors: Shionalyn Keenan
Published: September 2021

Theatre and Performance in the Neoliberal University: Responses to an Academy in Crisis practically examines the utilization of performance methodology within the university setting. This edited collection combines diverse expertise to demonstrate effective strategies for navigating our art, scholarship, and teaching while working at a neoliberal university. Intending to operate alongside, rather than within, Kim Solga presents research and case studies utilizing performance as both a methodology for research and a tool to improve pedagogy and community relationships. Providing hope to scholar-artists working in theatre and performance studies, Solga’s work inspires creativity and provides a form of collaboration to strengthen our field and ensure its continuance.
“Not Writing New Rules, Merely Rat-ifying”: Musical Theatre Goes Digital in Ratatouille: The Musical
Authors: Lusie Cuskey
Published: September 2021

On TikTok, #RatatouilleTheMusical was the pandemic daydream and collaborative creation of dozens of amateur and out-of-work theatre artists. The January 1 benefit performance of Ratatouille: The Musical ratified the work of its creators by bringing it to a broader audience, but did not always honor its tone and intent. Regardless of the product itself, however, Ratatouille: The Musical offers hope for the resilience and adaptibility of the rising generation of musical theatremakers.
Description and Pilot Evaluation of a Dreamer Ally Training for Higher Education Staff and Faculty
Authors: McWhirter Ellen Hawley , Yarris Kristin , Rojas-Araúz Bryan Ovidio
Published: September 2021

We describe a Dreamer Ally training provided to staff and faculty on a university campus and present results of a pilot evaluation of this training. The Dreamer Ally training was designed to (a) increase university faculty and staff awareness, understanding, and self-efficacy for working with Dreamer students and (b) stimulate action to make the campus more responsive to the challenges and contributions of Dreamer students. For the purpose of this study we define Dreamer students as inclusive of undocumented students, students with the temporary protection of DACA (Deferred Action for Childhood Arrivals), students who qualify for the state’s tuition equity program, and students from mixed legal status families. Study goals were to describe the training, gather pilot data on participant learning goals, post-training satisfaction and self-efficacy for supporting Dreamer students, and generate participant feedback about utility of training components and their plans for subsequent action. Participants completed questionnaires before and after the training. Responses to open-ended questions indicated that most participants attended in order to learn how to better support Dreamer students. Paired samples (pre and post) t-tests indicated significantly higher self-efficacy for supporting Dreamer students at posttest. Participant satisfaction with the training was high and found the information session content and working through different Dreamer student scenarios most useful. Action plans included changing program or unit websites to be more inclusive of Dreamers. Limitations include the absence of a control group. Findings can inform institutional efforts to raise faculty and staff awareness of and responsiveness to the challenges facing Dreamer students.
Fatigue and conformist traits in the performance of young swimmers
Authors: Núñez-Espinosa Cristian , Herrera-Valenzuela Tomas , Valdés-Badilla Pablo , Estrada-Goic Claudia
Published: September 2021

Objective: This study determines the relationship between the fatigue of adolescent swimmers in high-level competitions during two continuous periods of maximum performance and the degree that swimmers conform to norms during these periods.

Methods: We evaluated the conformist trait and three areas of fatigue in two consecutive competitive periods, in 25 young elite swimmers. The measures were evaluated before (_B) and after (_A) of pre (t1; t3) and pos (t2; t4) competition in each period. Millon Adolescent Clinical Inventory was applied for identifies the more adherens (AD; n=12) or detached from the norm (DN; n=13) conformist traits. Wingate test, Heart rate variability (RMSSD; SDNN), WISC-V, and Stroop test were evaluated.

Results: DN group present lower fatigue in t1 but an increase in t2, t3, and t4. AN present higher RMSSD_B and SDNN_B in t1. In t3, the mental fatigue of DN was correlated negatively with RMSSD_B; SDNN_B. Both groups had more SDNN_B than SDNN_A in t4.

Conclusions: Physical fatigue was important conditioning in both groups, however, the DN group may be more sensitive to physiological and mental fatigue directly affecting the performance.
CONTRIBUTION OF PRIMARY TEACHER EDUCATION CURRICULUM TO QUALITY PRIMARY EDUCATION IN UGANDA
Authors: Kagoda Alice Merab , Akullu Ezati Betty
Published: September 2021

With the frequent changes in education environment caused by dynamic economy, politics, and global trends among others, primary teacher education should keep abreast with these trends. However, in Uganda this has not been the case. While government designs new curriculum for primary schools, the changes in teacher education curriculum seem to be slower. Teacher educators are not familiar with the new trends in education such as ICT in teaching and learning, gender, learner centered education etc. The teaching materials are not easily available in the teacher training colleges because of shortages of funds. The study sought to: analyse the curriculum of Primary Teacher Education (PTE) since 1990, assess the challenges Primary Teacher Colleges (PTC) experience in the preparation of quality teachers and analyse the extent to which PTE curriculum is responding to the new trends in primary education. Using mainly interviews and focus group discussion, this paper explored the relationship between teacher preparation and quality of teachers produced. Findings showed that the curriculum of the teacher training colleges is not tailored to the requirements of the primary curriculum. In addition PTE faces many challenges that affect the preparation of teachers.
Key words: primary teacher education, primary school curriculum, quality education.
RECONCILING ADULT EDUCATION NEEDS FOR SUSTAINABLE DEVELOPMENT: THE CASE OF TRINIDAD AND TOBAGO SMALL SCALE FISHERIES
Authors: Mallalieu Kim I. , Sankarsingh Candice V.
Published: September 2021

The critical role of fisheries to food security and coastal livelihoods, as well as its impact on dwindling marine resources, motivate an examination of the degree to which education and training needs in the fisheries sector are met. This paper investigates the specific case of Trinidad and Tobago small scale fishers, a particularly vulnerable population whose livelihoods are bidirectionally linked to sustainable development.
The challenges of declining fish stocks, increasing market prices and the fierce competition presented by technology-based fishing techniques, present a persuasive case for context-appropriate education and training for Trinidad and Tobago small scale fisherfolk. Research was conducted to examine the training needs of these fisherfolk, as articulated by key industry stakeholders, including the fishers themselves; and to set these needs off against available training provisions. A reconciliation strategy for education and training was developed to respond to the needs of the industry as well as to the Caribbean priorities of sustainable development and fisheries management.
Key words: small scale fisheries, sustainable development, training needs specification.
HARDSHIPS IN HUNGARIAN TERTIARY EDUCATION: THE ECONOMIC ROLE OF PRIVATE INTERNAL RATE OF RETURN IN ONLINE EDUCATION
Authors: Mucsics Laszlo F.
Published: September 2021

The effects of global crises and the unique Hungarian economic difficulties render more and more hardships for non-full time students of higher education. The aim of this study twofold. It gives insight into how the ICTs are spread among the students of Karoly Robert College between 2006 and 2012 and examines the economic effect of private internal rate of return (IRR) by launching a form of online education in the changing environment of Hungarian tertiary education. In general, the study found that the student population is equipped with the proper up-to-date technology that enables using online education. In addition, with launching online education the students’ private IRR may also be increased significantly by reducing the cost of indirect cost. With the technological inventions and applications of the 21st century the Karoly Robert College designs and introduces a new learning environment for non-full time students since 2013.
Key words: e-education, structural reform, info-communication tools, private IRR to education.
Brentuximab vedotin in adult patients with HL CD30+ at high risk of relapse or progression following ASCT: a cost-analysis in Italy
Authors: Breschi Gian Luca , Demma Federica , Morelli Paolo , De Francesco Maria
Published: September 2021

Abstract

Introduction: In Hodgkin Lymphoma (HL), the early administration of brentuximab vedotin (BV) represents a highly effective treatment to consolidate patients after autologous stem cell transplantation (ASCT). For this indication, the Summary of Product Characteristics (SPC) reports a lower medical resource utilization in BV vs. placebo. This study aimed at assessing costs accrued by using BV in consolidation after ASCT and compare them with the resource consumption associated with the main options today used in Italy for HL.

Methods and results: A cost-analysis based on patients at high risk of relapse (HL CD30+-HR) after ASCT was developed by collecting data about health care consumption (drugs and monitoring). The model is described by two arms, "A," where BV is used as consolidation therapy after ASCT, and "B", where patients are treated only at the time of relapse. A 3-year time horizon and the Italian National Health System perspective were adopted. All data inputs for the analysis were sourced from the available literature and official list prices. The simulation was integrated by sensitivity analysis. The introduction of BV as consolidation therapy would allow savings in terms of drug acquisition and resource consumption. Over a 3-year time frame, the Consolidation arm’s overall expenditure was 137,059€ vs. 225,418€ in the Non-consolidation arm. Early after the ASCT, BV administration guarantees a long period free from relapses (5-year PFS is not reached), thus reducing the clinical and economic burden of the subsequent therapies needed to treat further relapses.

Conclusions: The present pharmacoeconomic analysis shows that the introduction of BV as consolidation therapy after ASCT represents a sustainable expenditure for the National Healthcare System (NHS) and a cost-saving paradigm when compared with the drug mainly used for treating the relapses.
Optimización de plataforma con movimiento rotacional horizontal controlable para un sistema de medición de funciones de transferencia de cabeza
Authors: Mendez Martín , Tommasini Fabián C. , Ferreyra Sebastián P. , Guido R. Martín , Bordón Juan Cruz , Scaliti Fermín
Published: September 2021

Para simular computacionalmente fuentes sonoras distribuidas espacialmente y lograr sonido tridimensional, se utilizan las funciones de transferencia de cabeza (HRTFs) como filtros. Para completar una esfera densa de puntos con estas funciones alrededor de un sujeto, es necesario posicionar una fuente sonora en diferentes ángulos y capturar las respuestas impulsivas mediante micrófonos ubicados en las orejas. Actualmente, estamos desarrollando un sistema de medición de HRTFs que cuenta con un arco soporte semicircular vertical para altavoces y una plataforma rotativa horizontal controlable donde se ubica el sujeto. Contamos con una plataforma diseñada originalmente para otro propósito y que soporta hasta 400 N de peso. En este trabajo se propone rediseñarla y optimizarla para permitir el movimiento de una persona sentada, tolerando hasta ~2200 N. En base a ensayos realizados sobre la plataforma actual, se detectaron situaciones físicas no deseadas y se propusieron soluciones validadas mediante modelos teóricos y simulaciones numéricas del comportamiento estático.
The future has arrived. Review of world innovative technologies in obstetrics and gynecology
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Kanayeva N. V. , Chishova G.V. ,   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai
Published: September 2021

Medical science does not stand still. Obstetrics and gynecology are dynamically developing disciplines, constantly updated with the latest achievements of medical science and practice. The article provides an overview of modern innovative technologies in obstetrics, gynecology, perinatology, reproductive medicine and medical genetics in Russia and in the world.
Vitamins and their role in children's health
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Kolesnikova S.M. , Filippova V. V. ,   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai
Published: September 2021

The role of vitamins in human health has been proven and undeniable. Childhood, with its intense and accelerated metabolic processes, is most sensitive to a lack of vitamins. Timely prevention of vitamin deficiency is the most optimal strategy in pediatric practice
Gendering Oil through the Lens of Advertising: Gender roles in oil company advertisements as a mirror of culture and of social change
Authors:   Department of Management and Engineering, Division of Languages for Specific Purposes, Linköping University, Linköping, Sweden, Vang Pamela
Published: September 2021

This electronic book is a longitudinal investigation into the ways in which oil companies have adapted their advertising to both influence and appeal to their contemporary publics. Taking a dramaturgical approach, it examines the roles and attitudes attributed to the characters that populate the advertisements and with whom the intended audiences should identify. The analysis shows that despite the fact that society is striving towards increased gender equality, the general narrative of oil companies remains unchanged. The casting of the advertisements shows that oil and its derivatives are provided and developed by strong, heroic and competent men to ease and facilitate the lives of the weaker, dependent female population.
Protein Complex Organization Imposes Constraints on Proteome Dysregulation in Cancer
Authors: Senger Gökçe , Schaefer Martin H.
Published: September 2021

Protein assembly is a highly dynamic process and proteins can interact in different ways and stoichiometries within a complex. The importance of maintaining protein stoichiometry for complex function and avoiding aggregation of orphan subunits has been demonstrated. However, how exactly the organization of proteins into complexes constrains differential protein abundance in extreme cellular conditions like cancer, where a lot of protein abundance changes occur, has not been systematically investigated. To study this, we collected proteomic data made available by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) to quantify proteomic changes during carcinogenesis and systematically tested five interaction types in complexes to investigate which of these features impact on protein abundance correlation patterns in cancer. We found that higher than expected fraction of protein complex subunits does not show changes in their abundances compared to those in the normal samples. Furthermore, we found that the way proteins interact in complexes indeed constrains their co-abundance patterns. Our results highlight the role of the interactions between the proteins and the need of cancer cells to deal with aberrant changes in protein abundance.
Biomechanical Evaluation of Different Surgical Approaches for the Treatment of Adjacent Segment Diseases After Primary Anterior Cervical Discectomy and Fusion: A Finite Element Analysis
Authors: Ke Wencan , Chen Chao , Wang Bingjin , Hua Wenbin , Lu Saideng , Song Yu , Luo Rongjin , Liao Zhiwei , Li Gaocai , Ma Liang , Shi Yunsong , Wang Kun , Li Shuai , Wu Xinghuo , Zhang Yukun , Yang Cao
Published: September 2021

Symptomatic adjacent segment disease (ASD) is a common challenge after anterior cervical discectomy and fusion (ACDF). The objective of this study was to compare the biomechanical effects of a second ACDF and laminoplasty for the treatment of ASD after primary ACDF. We developed a finite element (FE) model of the C2-T1 based on computed tomography images. The FE models of revision surgeries of ACDF and laminoplasty were simulated to treat one-level and two-level ASD after primary ACDF. The range of motion (ROM) and intradiscal pressure (IDP) of the adjacent segments, and stress in the cord were analyzed to investigate the biomechanical effects of the second ACDF and laminoplasty. The results indicated that revision surgery of one-level ACDF increased the ROM and IDP at the C2–C3 segment, whereas two-level ACDF significantly increased the ROM and IDP at the C2–C3 and C7-T1 segments. Furthermore, no significant changes in the ROM and IDP of the laminoplasty models were observed. The stress in the cord of the re-laminoplasty model decreased to some extent, which was higher than that of the re-ACDF model. In conclusion, both ACDF and laminoplasty can relieve the high level of stress in the spinal cord caused by ASD after primary ACDF, whereas ACDF can achieve better decompression effect. Revision surgery of the superior ACDF or the superior and inferior ACDF after the primary ACDF increased the ROM and IDP at the adjacent segments, which may be the reason for the high incidence of recurrent ASD after second ACDF.
Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche
Authors: Shi Xueke , Luo Jingjing , Weigel Kelsey J. , Hall Spencer C. , Du Danfeng , Wu Fanglong , Rudolph Michael C. , Zhou Hongmei , Young Christian D. , Wang Xiao-Jing
Published: September 2021

Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We generated CAFs from K15.KrasG12D.Smad4–/– mouse SCCs. RNA expression analyses demonstrated that CAFs had enriched transforming growth factor-beta (TGFβ) signaling compared to normal tissue-associated fibroblasts (NAFs), therefore we assessed how TGFβ-enriched CAFs impact SCC metastasis. We co-injected SCC cells with CAFs to the skin, tail vein, or the lung to mimic sequential steps of lung metastasis. CAFs increased SCC volume only in lung co-transplantations, characterized with increased proliferation and angiogenesis and decreased apoptosis compared to NAF co-transplanted SCCs. These CAF effects were attenuated by a clinically relevant TGFβ receptor inhibitor, suggesting that CAFs facilitated TGFβ-dependent SCC cell seeding and survival in the lung. CAFs also increased tumor volume when co-transplanted to the lung with limiting numbers of SCC cancer stem cells (CSCs). In vitro, CSC sphere formation and invasion were increased either with co-cultured CAFs or with CAF conditioned media (which contains the highest TGFβ1 concentration) and these CAF effects were blocked by TGFβ inhibition. Further, TGFβ activation was higher in primary human oral SCCs with lung metastasis than SCCs without lung metastasis. Similarly, TGFβ activation was detected in the lungs of mice with micrometastasis. Our data suggest that TGFβ-enriched CAFs play a causal role in CSC seeding and expansion in the lung during SCC metastasis, providing a prognostic marker and therapeutic target for SCC lung metastasis.
Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach
Authors: Marracino Luisa , Fortini Francesca , Bouhamida Esmaa , Camponogara Francesca , Severi Paolo , Mazzoni Elisa , Patergnani Simone , D’Aniello Emanuele , Campana Roberta , Pinton Paolo , Martini Fernanda , Tognon Mauro , Campo Gianluca , Ferrari Roberto , Vieceli Dalla Sega Francesco , Rizzo Paola
Published: September 2021

Dysregulation of the Notch pathway is implicated in the pathophysiology of cardiovascular diseases (CVDs), but, as of today, therapies based on the re-establishing the physiological levels of Notch in the heart and vessels are not available. A possible reason is the context-dependent role of Notch in the cardiovascular system, which would require a finely tuned, cell-specific approach. MicroRNAs (miRNAs) are short functional endogenous, non-coding RNA sequences able to regulate gene expression at post-transcriptional levels influencing most, if not all, biological processes. Dysregulation of miRNAs expression is implicated in the molecular mechanisms underlying many CVDs. Notch is regulated and regulates a large number of miRNAs expressed in the cardiovascular system and, thus, targeting these miRNAs could represent an avenue to be explored to target Notch for CVDs. In this Review, we provide an overview of both established and potential, based on evidence in other pathologies, crosstalks between miRNAs and Notch in cellular processes underlying atherosclerosis, myocardial ischemia, heart failure, calcification of aortic valve, and arrhythmias. We also discuss the potential advantages, as well as the challenges, of using miRNAs for a Notch-based approach for the diagnosis and treatment of the most common CVDs.
HCG18 Participates in Vascular Invasion of Hepatocellular Carcinoma by Regulating Macrophages and Tumor Stem Cells
Authors: Zhang Liwei , Wang Zhiwei , Li Mingxing , Sun Peng , Bai Tao , Wang Wang , Bai Hualong , Gou Jianjun , Wang Zhiju
Published: September 2021

Objectives

To identify key genes involved in vascular invasion in hepatocellular carcinoma (HCC), to describe their regulatory mechanisms, and to explore the immune microenvironment of HCC.

Methodology

In this study, the genome, transcriptome, and immune microenvironment of HCC were assessed by using multi-platform data from The Cancer Genome Atlas (n= 373) and GEO data (GSE149614). The key regulatory networks, transcription factors and core genes related to vascular invasion and prognosis were explored based on the CE mechanism. Survival analysis and gene set enrichment were used to explore pathways related to vascular invasion. Combined with single-cell transcriptome data, the distribution of core gene expression in various cells was observed. Cellular communication analysis was used to identify key cells associated with vascular invasion. Pseudo-temporal locus analysis was used to explore the regulation of core genes in key cell phenotypes. The influence of core genes on current immune checkpoint therapy was evaluated and correlations with tumor stem cell scores were explored.

Results

We obtained a network containing 1,249 pairs of CE regulatory relationships, including 579 differential proteins, 28 non-coding RNAs, and 37 miRNAs. Three key transcription factors, ILF2, YBX1, and HMGA1, were identified, all regulated by HCG18 lncRNA. ScRNAseq showed that HCG18 co-localized with macrophages and stem cells. CIBERSORTx assessed 22 types of immune cells in HCC and found that HCG18 was positively correlated with M0 macrophages, while being negatively correlated with M1 and M2 macrophages, monocytes, and dendritic cells. Cluster analysis based on patient prognosis suggested that regulating phenotypic transformation of macrophages could be an effective intervention for treating HCC. At the same time, higher expression of HCG18, HMGA1, ILF2, and YBX1 was associated with a higher stem cell score and less tumor differentiation. Pan cancer analysis indicated that high expression of HCG18 implies high sensitivity to immune checkpoint therapy.

Conclusion

HCG18 participates in vascular invasion of HCC by regulating macrophages and tumor stem cells through three key transcription factors, YBX1, ILF2, and HMGA1.
Protein Arginine Methyltransferase 5 Functions via Interacting Proteins
Authors: Liang Zhenzhen , Wen Chaowei , Jiang Heya , Ma Shumei , Liu Xiaodong
Published: September 2021

The protein arginine methyltransferases (PRMTs) are involved in such biological processes as transcription regulation, DNA repair, RNA splicing, and signal transduction, etc. In this study, we mainly focused on PRMT5, a member of the type II PRMTs, which functions mainly alongside other interacting proteins. PRMT5 has been shown to be overexpressed in a wide variety of cancers and other diseases, and is involved in the regulation of Epstein-Barr virus infection, viral carcinogenesis, spliceosome, hepatitis B, cell cycles, and various signaling pathways. We analyzed the regulatory roles of PRMT5 and interacting proteins in various biological processes above-mentioned, to elucidate for the first time the interaction between PRMT5 and its interacting proteins. This systemic analysis will enrich the biological theory and contribute to the development of novel therapies.
iPS Cell-Based Model for MAPT Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression
Authors: Strauß Tabea , Marvian-Tayaranian Amir , Sadikoglou Eldem , Dhingra Ashutosh , Wegner Florian , Trümbach Dietrich , Wurst Wolfgang , Heutink Peter , Schwarz Sigrid C. , Höglinger Günter U.
Published: September 2021

The H1 haplotype of the microtubule-associated protein tau (MAPT) gene is a common genetic risk factor for some neurodegenerative diseases such as progressive supranuclear palsy, corticobasal degeneration, and Parkinson’s disease. The molecular mechanism causing the increased risk for the named diseases, however, remains unclear. In this paper, we present a valuable tool of eight small molecule neural precursor cell lines (smNPC) homozygous for the MAPT haplotypes (four H1/H1 and four H2/H2 cell lines), which can be used to identify MAPT-dependent phenotypes. The employed differentiation protocol is fast due to overexpression of NEUROGENIN-2 and therefore suitable for high-throughput approaches. A basic characterization of all human cell lines was performed, and their TAU and α-SYNUCLEIN profiles were compared during a differentiation time of 30 days. We could identify higher levels of conformationally altered TAU in cell lines carrying the H2 haplotype. Additionally, we found increased expression levels of α-SYNUCLEIN in H1/H1 cells. With this resource, we aim to fill a gap in neurodegenerative disease modeling with induced pluripotent stem cells (iPSC) for sporadic tauopathies.