bluuebunny/crossref_metadata_2025 huggingface dataset:
46,XX Testicular Disorder of Sex Development (DSD): A Case Report and Systematic Review
Authors: Terribile Marco , Stizzo Marco , Manfredi Celeste , Quattrone Carmelo , Bottone Francesco , Giordano Dario Ranieri , Bellastella Giuseppe , Arcaniolo Davide , De Sio Marco
Published: July 2019

Background and objectives: XX male syndrome is part of the disorders of sex development (DSD). The patients generally have normal external genitalia and discover their pathology in adulthood because of infertility. There are no guidelines regarding XX male syndrome, so the aim of our study was to evaluate the literature evidence in order to guide the physicians in the management of these type of patients. Materials and Methods: We performed a systematic review of the available literature in September 2018, using MEDLINE, Web of Science, Embase and Google Scholar database to search for all published studies regarding XX male syndrome according to PRISMA guidelines. The following search terms were used: “46 XX male”, “DSD”, “infertility”, “hypogonadism”. Results: After appropriate screening we selected 37 papers. Mean (SD) age was 33.14 (11.4) years. Hair distribution was normal in 29/39 patients (74.3%), gynecomastia was absent in 22/39 cases (56.4%), normal testes volume was reported in 0/14, penis size was normal in 26/32 cases (81.2%), pubic hair had a normal development in 6/7 patients (85.7%), normal erectile function was present in 27/30 cases (90%) and libido was preserved in 20/20 patients (100%). The data revealed the common presence of hypergonadotropic hypogonadism. All patients had a 46,XX karyotype. The sex-determining region Y (SRY) gene was detected in 51/57 cases. The position of the SRY was on the Xp in the 97% of the cases. Conclusions: An appropriate physical examination should include the evaluation of genitalia to detect cryptorchidism, hypospadias, penis size, and gynecomastia; it is important to use a validated questionnaire to evaluate erectile dysfunction, such as the International Index of Erectile Function (IIEF). Semen analysis is mandatory and so is the karyotype test. Abdominal ultrasound is useful in order to exclude residual Müllerian structures. Genetic and endocrine consultations are necessary to assess a possible hypergonadotropic hypogonadism. Testicular sperm extraction is not recommended, and adoption or in vitro fertilization with a sperm donor are fertility options.
Effect of Substrate Roughness on Oxidation Resistance of an Aluminized Ni-Base Superalloy
Authors: Nowak Wojciech J. , Ochał Kamil , Wierzba Patrycja , Gancarczyk Kamil , Wierzba Bartek
Published: July 2019

In the present work, it is shown that the surface preparation method used on two Ni-based superalloys prior to aluminizing chemical vapor deposition (CVD) is one of the most important factors determining the oxidation resistance of aluminized Ni-based superalloys. It was found that grit-blasting the substrate surface negatively affects the oxidation resistance of the aluminized coatings. For grit-blasted and aluminized IN 625, a thicker outer NiAl coating was formed compared to that of IN 738. In contrast, no effect on NiAl coating thickness was found for grit-blasted and aluminized IN 738. However, a thicker interdiffusion zone (IDZ) was observed. It was shown that the systems with grit-blasted surfaces reveal worse oxidation resistance during thermal shock tests—namely, a higher mass loss was observed for both grit-blasted and aluminized alloys, as compared to ground and aluminized alloys. A possible reason for this effect of remaining alumina particles originating from surface grit-blasting on the diffusion processes and stress distribution at the coating/substrate is proposed.
1H-NMR Metabolomics Identifies Significant Changes in Metabolism over Time in a Porcine Model of Severe Burn and Smoke Inhalation
Authors: Hendrickson Cole , Linden Katharina , Kreyer Stefan , Beilman Gregory , Scaravilli Vittorio , Wendorff Daniel , Necsoiu Corina , Batchinsky Andriy I. , Cancio Leopoldo C. , Chung Kevin K. , Lusczek Elizabeth R.
Published: July 2019

Burn injury initiates a hypermetabolic response leading to muscle catabolism and organ dysfunction but has not been well-characterized by high-throughput metabolomics. We examined changes in metabolism over the first 72 h post-burn using proton nuclear magnetic resonance (1H-NMR) spectroscopy and serum from a porcine model of severe burn injury. We sought to quantify the changes in metabolism that occur over time in response to severe burn and smoke inhalation in this preliminary study. Fifteen pigs received 40% total body surface area (TBSA) burns with additional pine bark smoke inhalation. Arterial blood was drawn at baseline (pre-burn) and every 24 h until 72 h post-injury or death. The aqueous portion of each serum sample was analyzed using 1H-NMR spectroscopy and metabolite concentrations were used for principal component analysis (PCA). Thirty-eight metabolites were quantified in 39 samples. Of these, 31 showed significant concentration changes over time (p < 0.05). PCA revealed clustering of samples by time point on a 2D scores plot. The first 48 h post-burn were characterized by high concentrations of histamine, alanine, phenylalanine, and tyrosine. Later timepoints were characterized by rising concentrations of 2-hydroxybutyrate, 3-hydroxybutyrate, acetoacetate, and isovalerate. No significant differences in metabolism related to mortality were observed. Our work highlights the accumulation of organic acids resulting from fatty acid catabolism and oxidative stress. Further studies will be required to relate accumulation of the four organic carboxylates identified in this analysis to outcomes from burn injury.
NMR Based Metabolomics Comparison of Different Blood Sampling Techniques in Awake and Anesthetized Rats
Authors: Du Hongying , Li Shuang , Zhang Yingfeng , Guo Huiling , Wu Liang , Liu Huili , Manyande Anne , Xu Fuqiang , Wang Jie
Published: July 2019

The composition of body fluids has become one of the most commonly used methods for diagnosing various diseases or monitoring the drug responses, especially in serum/plasma. It is therefore vital for investigators to find an appropriate way to collect blood samples from laboratory animals. This study compared blood samples collected from different sites using the NMR based metabolomics approach. Blood samples were collected from the saphenous vein (awake state), tail vein (awake and anesthetized states after administration of sevoflurane or pentobarbital) and the inferior thoracic vena cava (ITVC, anesthetized state). These approaches from the saphenous and tail veins have the potential to enable the collection of multiple samples, and the approach from ITVC is the best method for the collection of blood for the terminate state. The compositions of small molecules in the serum were determined using the 1H-NMR method, and the data were analyzed with traditional correlation analysis, principle component analysis (PCA) and OPLS-DA methods. The results showed that acute anesthesia significantly influenced the composition of serum in a very short period, such as the significant increase in glucose, and decrease in lactate. This indicates that it is better to obtain blood samples under the awake state. From the perspective of animal welfare and multiple sampling, the current study shows that the saphenous vein and tail vein are the best locations to collect multiple blood samples for a reduced risk of injury in the awake state. Furthermore, it is also suitable for investigating pharmacokinetics and the effects of drug intervention on animals.
Modelling of Mechanical Behavior of Biopolymer Alginate Aerogels Using the Bonded-Particle Model
Authors: Dosta Maksym , Jarolin Kolja , Gurikov Pavel
Published: July 2019

A novel mesoscale modelling approach for the investigation of mechanical properties of alginate aerogels is proposed. This method is based on the discrete element method and bonded-particle model. The nanostructure of aerogel is not directly considered, instead the highly porous structure of aerogels is represented on the mesoscale as a set of solid particles connected by solid bonds. To describe the rheological material behavior, a new elastic-plastic functional model for the solids bonds has been developed. This model has been derived based on the self-similarity principle for the material behavior on the macro and mesoscales. To analyze the effectiveness of the proposed method, the behavior of alginate aerogels with different crosslinking degrees (calcium content) was analyzed. The comparison between experimental and numerical results has shown that the proposed approach can be effectively used to predict the mechanical behavior of aerogels on the macroscale.
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism
Authors: Hong Fan , Pan Shijia , Guo Yuan , Xu Pengfei , Zhai Yonggong
Published: July 2019

It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs) were first recognized as enhancers of peroxisome proliferation. Consequently, many studies in different fields have illustrated that PPARs are nuclear receptors that participate in nutrient and energy metabolism and regulate cellular and whole-body energy homeostasis during lipid and carbohydrate metabolism, cell growth, cancer development, and so on. With increasing challenges to human health, PPARs have attracted much attention for their ability to ameliorate metabolic syndromes. In our previous studies, we found that the complex functions of PPARs may be used as future targets in obesity and atherosclerosis treatments. Here, we review three types of PPARs that play overlapping but distinct roles in nutrient and energy metabolism during different metabolic states and in different organs. Furthermore, research has emerged showing that PPARs also play many other roles in inflammation, central nervous system-related diseases, and cancer. Increasingly, drug development has been based on the use of several selective PPARs as modulators to diminish the adverse effects of the PPAR agonists previously used in clinical practice. In conclusion, the complex roles of PPARs in metabolic networks keep these factors in the forefront of research because it is hoped that they will have potential therapeutic effects in future applications.
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
Authors: CHATTERJEE Sudipta , Chi-leung HUI Patrick
Published: July 2019

This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and these features of the biopolymers impart sensitivity to act differently under different temperatures and pH conditions. The stimuli-responsive characters of these natural polymers have been discussed in the review, and their respective applications in drug delivery and textile especially for textile-based transdermal therapy have been emphasized. Some practically important thermo-responsive polymers such as pluronic F127 (PF127) and poly(N-isopropylacrylamide) (pNIPAAm) of synthetic origin have been discussed in the review and they are of great importance commercially because of their in situ gel formation capacity. Some pH-responsive synthetic polymers have been discussed depending on their surface charge, and their drug delivery and textile applications have been discussed in this review. The selected stimuli-responsive polymers of synthetic origin are commercially available. Above all, the applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications. A special insight has been given for stimuli-responsive hydrogel drug delivery systems for textile-based transdermal therapy, which is critical for the treatment of skin disease atopic dermatitis.
Dihydrogen Bond in the Aminoborane Complex of a Nicergoline Intermediate
Authors: Čejka Jan , Cvak Ladislav , Žižková Simona , Kratochvíl Bohumil , Jegorov Alexandr
Published: July 2019

An aminoborane side product from the nicergoline manufacture process was identified by single-crystal X-ray diffraction. As boranes of pharmaceutical molecules are quite rare, the binding potential of the BH3 group was investigated and compared with similar compounds using Cambridge Structural Database (CSD). Surprisingly, the packing was stabilized by a dihydrogen bond, which triggered a false alert for too-short contact of hydrogen atoms in IUCR checkCIF. As the dihydrogen bond concept is not widely known, such an alert might mislead crystallographers to force –CH3 optimal geometry to –BH3 groups. The B–H distances equal to or less than 1.0 Å (17% of the CSD structures) are substantially biased when analyzing the structures of aminoborane complexes in CSD. To conduct proper searching, B–H bond length normalization should be applied in the CSD search.
Asymmetric Whole-Cell Bio-Reductions of (R)-Carvone Using Optimized Ene Reductases
Authors: Mähler Christoph , Burger Christian , Kratzl Franziska , Weuster-Botz Dirk , Castiglione Kathrin
Published: July 2019

(2R,5R)-dihydrocarvone is an industrially applied building block that can be synthesized by site-selective and stereo-selective C=C bond bio-reduction of (R)-carvone. Escherichia coli (E. coli) cells overexpressing an ene reductase from Nostoc sp. PCC7120 (NostocER1) in combination with a cosubstrate regeneration system proved to be very effective biocatalysts for this reaction. However, the industrial applicability of biocatalysts is strongly linked to the catalysts’ activity. Since the cell-internal NADH concentrations are around 20-fold higher than the NADPH concentrations, we produced E. coli cells where the NADPH-preferring NostocER1 was exchanged with three different NADH-accepting NostocER1 mutants. These E. coli whole-cell biocatalysts were used in batch operated stirred-tank reactors on a 0.7 l-scale for the reduction of 300 mM (R)-carvone. 287 mM (2R,5R)-dihydrocarvone were formed within 5 h with a diasteromeric excess of 95.4% and a yield of 95.6%. Thus, the whole-cell biocatalysts were strongly improved by using NADH-accepting enzymes, resulting in an up to 2.1-fold increased initial product formation rate leading to a 1.8-fold increased space-time yield when compared to literature.
Operationalizing the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Cancer Prevention Recommendations: A Standardized Scoring System
Authors: Shams-White Marissa M. , Brockton Nigel T. , Mitrou Panagiota , Romaguera Dora , Brown Susannah , Bender Alice , Kahle Lisa L. , Reedy Jill
Published: July 2019

Background: Following the publication of the 2018 World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) Third Expert Report, a collaborative group was formed to develop a standardized scoring system and provide guidance for research applications. Methods: The 2018 WCRF/AICR Cancer Prevention Recommendations, goals, and statements of advice were examined to define components of the new Score. Cut-points for scoring were based on quantitative guidance in the 2018 Recommendations and other guidelines, past research that operationalized 2007 WCRF/AICR Recommendations, and advice from the Continuous Update Project Expert Panel. Results: Eight of the ten 2018 WCRF/AICR Recommendations concerning weight, physical activity, diet, and breastfeeding (optional), were selected for inclusion. Each component is worth one point: 1, 0.5, and 0 points for fully, partially, and not meeting each recommendation, respectively (Score: 0 to 7–8 points). Two recommendations on dietary supplement use and for cancer survivors are not included due to operational redundancy. Additional guidance stresses the importance of accounting for other risk factors (e.g., smoking) in relevant models. Conclusions: The proposed 2018 WCRF/AICR Score is a practical tool for researchers to examine how adherence to the 2018 WCRF/AICR Recommendations relates to cancer risk and mortality in various adult populations.
Dietary Care for ADPKD Patients: Current Status and Future Directions
Authors: Carriazo Sol , Perez-Gomez Maria Vanessa , Cordido Adrian , García-González Miguel Angel , Sanz Ana Belen , Ortiz Alberto , Sanchez-Niño Maria Dolores
Published: July 2019

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, and tolvaptan is the only therapy available. However, tolvaptan slows but does not stop disease progression, is marred by polyuria, and most patients worldwide lack access. This and recent preclinical research findings on the glucose-dependency of cyst-lining cells have renewed interest in the dietary management of ADPKD. We now review the current dietary recommendations for ADPKD patients according to clinical guidelines, the evidence base for those, and the potential impact of preclinical studies addressing the impact of diet on ADPKD progression. The clinical efficacy of tolvaptan has put the focus on water intake and solute ingestion as modifiable factors that may impact tolvaptan tolerance and ADPKD progression. By contrast, dietary modifications suggested to ADPKD patients, such as avoiding caffeine, are not well supported and their impact is unknown. Recent studies have identified a chronic shift in energy production from mitochondrial oxidative phosphorylation to aerobic glycolysis (Warburg effect) as a contributor to cyst growth, rendering cyst cells exquisitely sensitive to glucose availability. Therefore, low calorie or ketogenic diets have delayed preclinical ADPKD progression. Additional preclinical data warn of potential negative impact of excess dietary phosphate or oxalate in ADPKD progression.
Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy
Authors: Melino Sonia , Leo Sara , Toska Papajani Vilma
Published: July 2019

Type 2 diabetes mellitus (DM) is a socially relevant chronic disease with high prevalence worldwide. DM may lead to several vascular, macrovascular, and microvascular complications (cerebrovascular, coronary artery, and peripheral arterial diseases, retinopathy, neuropathy, and nephropathy), often accelerating the progression of atherosclerosis. Dietary therapy is generally considered to be the first step in the treatment of diabetic patients. Among the current therapeutic options, such as insulin therapy and hypoglycemic drugs, in recent years, attention has been shifting to the effects and properties—that are still not completely known—of medicinal plants as valid and inexpensive therapeutic supports with limited side effects. In this review, we report the relevant effects of medicinal plants and nutraceuticals in diabetes. In particular, we paid attention to the organosulfur compounds (OSCs) present in plant extracts that due to their antioxidant, hypoglycemic, anti-inflammatory, and immunomodulatory effects, can contribute as cardioprotective agents in type 2 DM. OSCs derived from garlic (Allium sp.), due to their properties, can represent a valuable support to the diet in type 2 DM, as outlined in this manuscript based on both in vitro and in vivo studies. Moreover, a relevant characteristic of garlic OSCs is their ability to produce the gasotransmitter H2S, and many of their effects can be explained by this property. Indeed, in recent years, several studies have demonstrated the relevant effects of endogenous and exogenous H2S in human DM, including by in vitro and in vivo experiments and clinical trials; therefore, here, we summarize the effects and the underlying molecular mechanisms of H2S and natural H2S donors.
Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
Authors: Inada Natalia Mayumi , Buzzá Hilde Harb , Leite Marieli Fernanda Martins , Kurachi Cristina , Trujillo Jose Roberto , de Castro Cynthia Aparecida , Carbinatto Fernanda Mansano , Lombardi Welington , Bagnato Vanderlei Salvador
Published: July 2019

(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix.
The Geology of the Middle Cam Valley, Cambridgeshire, UK
Authors: Boreham Steve , Leszczynska Karolina
Published: July 2019

This study offers a new understanding of the stratigraphy and context of the Pleistocene (including Elsterian and Weichselian) and Holocene deposits of the Middle Cam valley, Cambridgeshire, United Kingdom, and provides a unique and detailed view of the sediment architecture of these valley-fill and interfluve sediments. The new insights into the geology of the area, including dating, pollen analyses, and sediment architecture, are presented with reference to a series of nine cross-sections through Holocene and Pleistocene deposits, as well as Cretaceous bedrock across the region. The structural geology of the bedrock and the stratigraphic arrangement of younger deposits are used to explain the landscape evolution of the area.
Analytical Approximation Model for Quadratic Phase Error Introduced by Orbit Determination Errors in Real-Time Spaceborne SAR Imaging
Authors: Yan Xiaoyu , Chen Jie , Nies Holger , Loffeld Otmar
Published: July 2019

Research on real-time spaceborne synthetic aperture radar (SAR) imaging has emerged as satellite computation capability has increased and applications of SAR imaging products have expanded. The orbit determination data of a spaceborne SAR platform are essential for the SAR imaging procedure. In real-time SAR imaging, onboard orbit determination data cannot achieve a level of accuracy that is equivalent to the orbit ephemeris in ground-based SAR processing, which requires a long processing time using common ground-based SAR imaging procedures. It is important to study the influence of errors in onboard real-time orbit determination data on SAR image quality. Instead of the widely used numerical simulation method, an analytical approximation model of the quadratic phase error (QPE) introduced by orbit determination errors is proposed. The proposed model can provide approximation results at two granularities: approximations with a satellite’s true anomaly as the independent variable and approximations for all positions in the satellite’s entire orbit. The proposed analytical approximation model reduces simulation complexity, extent of calculations, and the processing time. In addition, the model reveals the core of the process by which errors are transferred to QPE calculations. A detailed comparison between the proposed method and a numerical simulation method proves the correctness and reliability of the analytical approximation model. With the help of this analytical approximation model, the technical parameter iteration procedure during the early-stage development of an onboard real-time SAR imaging mission will likely be accelerated.
Evaluation and Comparison of Random Forest and A-LSTM Networks for Large-scale Winter Wheat Identification
Authors: He Tianle , Xie Chuanjie , Liu Qingsheng , Guan Shiying , Liu Gaohuan
Published: July 2019

Machine learning comprises a group of powerful state-of-the-art techniques for land cover classification and cropland identification. In this paper, we proposed and evaluated two models based on random forest (RF) and attention-based long short-term memory (A-LSTM) networks that can learn directly from the raw surface reflectance of remote sensing (RS) images for large-scale winter wheat identification in Huanghuaihai Region (North-Central China). We used a time series of Moderate Resolution Imaging Spectroradiometer (MODIS) images over one growing season and the corresponding winter wheat distribution map for the experiments. Each training sample was derived from the raw surface reflectance of MODIS time-series images. Both models achieved state-of-the-art performance in identifying winter wheat, and the F1 scores of RF and A-LSTM were 0.72 and 0.71, respectively. We also analyzed the impact of the pixel-mixing effect. Training with pure-mixed-pixel samples (the training set consists of pure and mixed cells and thus retains the original distribution of data) was more precise than training with only pure-pixel samples (the entire pixel area belongs to one class). We also analyzed the variable importance along the temporal series, and the data acquired in March or April contributed more than the data acquired at other times. Both models could predict winter wheat coverage in past years or in other regions with similar winter wheat growing seasons. The experiments in this paper showed the effectiveness and significance of our methods.
Energy Evaluation of Deep-Lane Autonomous Vehicle Storage and Retrieval System
Authors: Guerrazzi Emanuele , Mininno Valeria , Aloini Davide , Dulmin Riccardo , Scarpelli Claudio , Sabatini Marco
Published: July 2019

With the rise of a consciousness in warehousing sustainability, an increasing number of autonomous vehicle storage and retrieval systems (AVS/RS) is diffusing among automated warehouses. Moreover, manufacturers are offering the option of equipping machines with energy recovery systems. This study analyzed a deep-lane AVS/RS provided with an energy recovery system in order to make an energy evaluation for such a system. A simulator able to emulate the operation of the warehouse has been developed, including a travel-time and an energy model to consider the real operating characteristics of lifts, shuttles and satellites. Referring to a single command cycle with a basic storing and picking algorithm for multiple-depth channels, energy balance and recovery measurements have been presented and compared to those of a traditional crane-based system. Results show significant savings in energy consumption with the use of a deep-lane AVS/RS.
Reporting within the Corridor of Conformance: Managerial Perspectives on Work Environment Disclosures in Corporate Social Responsibility Reporting
Authors: Dixon Shane M. , Searcy Cory , Neumann W. Patrick
Published: July 2019

This paper examines managerial perspectives on work environment (WE) disclosures in corporate social responsibility (CSR) reports. WE encompasses all aspects of the design and management of the work system that affect the employees’ interactions with the workplace. The data are drawn from interviews with 20 CSR managers in large companies that are recognized as high performers in CSR. Managers reported that WE disclosures were an important part of CSR reporting and had several benefits—for example, it helped to maintain companies’ reputations as good places to work, which were of interest to both investors and potential employees. However, WE reporting was at a low level, focusing predominantly on occupational health and safety performance indicators, such as the number of employee injuries per year. We suggest that organizations derive legitimacy by reporting WE disclosures within a corridor of conformance that permits a low level of reporting and a great deal of latitude regarding what topics and how topics are disclosed, provided organizations meet institutional expectations. The corridor is maintained by an institutional environment in which, from participants’ perspectives, few external stakeholders were interested in WE disclosures representing employee well-being (e.g., psychological health) and the prevailing CSR reporting standards and guidelines provide scant information about employee health.
Efficiency Evaluation of Urban Road Transport and Land Use in Hunan Province of China Based on Hybrid Data Envelopment Analysis (DEA) Models
Authors: Yang Tingting , Guan Xuefeng , Qian Yuehui , Xing Weiran , Wu Huayi
Published: July 2019

Urban road transport and land use (RTLU) jointly promote economic development by concentrating labor, material, and capital. This paper presents an integrated RTLU efficiency analysis that explores the degree of coordination between these two systems to provide guidance for future adaptations necessary for sustainable urban development. Both a super efficiency Data Envelopment Analysis model and window analysis were used to spatiotemporally evaluate RTLU efficiency from 2012 to 2016 in 14 cities of Hunan province, central China. The Malmquist index was decomposed into technical efficiency and technology change to reveal reasons for changes in RTLU efficiency. These evaluation results show regional disparities in efficiency across Hunan province, with western cities being the least efficient. Eight cities showed an increasing trend in RTLU efficiency while Yueyang exhibited a decreasing trend. In 13 of 14 regions, productivity improved every year. At the same time, five regions had a decline in technical efficiency even though technical progress increased in all regions. Our analysis shows that greater investment in road transport and urban construction are not enough to ensure sustainable urban growth. Policy must instead promote the full use of current resources according to local conditions to meet local, regional, and national development goals.
Extension of the Lean 5S Methodology to 6S with An Additional Layer to Ensure Occupational Safety and Health Levels
Authors: Jiménez Mariano , Romero Luis , Fernández Jon , Espinosa María del Mar , Domínguez Manuel
Published: July 2019

This paper proposes an expansion of the Lean 5S methodology, which includes the concept of Safety–Security as 6S. Implementation was done by a standardized process tested in a pilot area that is part of the Integrated Industrial Manufacturing System Laboratory at the Higher Technical School of Engineering (ICAI). The additional 6S phase (Safety-Security) thoroughly reviews all areas of an industrial plant by analyzing the risks at each workstation, which let employees be fitted out with protection resources depending on each of their personal characteristics and to guarantee the safety of the workstation by strictly complying with occupational safety and health and machinery use standards, which must hold a CE certificate of compliance. The main objective was to increase the scope of 5S methodology to respond to the occupational safety and health needs for machines required in optimizing production processes. It is important to remember that companies must guarantee that their employees use personal protection equipment (PPE) at their work posts or stations that protect them properly from risks to their health and safety and that cannot be prevented or sufficiently limited by using collective means of protection or by adopting work organization measures. The industrial resources employed in the pilot area chosen for 6S implementation were a sheet metal deformation and cutting line comprised of a punch press, feeder, and winder, as well as a conventional machine tool with minimum safety specifications and without CE certification. Until now, there had been no plans to implement a 6S tool in this laboratory. However, given that the existing safety risk to operators is high, the implementation has led to obtaining optimal results, which justify the success of the 6S methodology proposal. In short, it lets us advance towards the zero accident target.
Development of a Model for Predicting Probabilistic Life-Cycle Cost for the Early Stage of Public-Office Construction
Authors: Jin Zhengxun , Kim Jonghyeob , Hyun Chang-taek , Han Sangwon
Published: July 2019

Decisions made in the early stages of construction projects significantly influence the costs incurred in subsequent stages. Therefore, such decisions must be based on the life-cycle cost (LCC), which includes the maintenance, repair, and replacement (MRR) costs in addition to construction costs. Furthermore, as uncertainty is inherent during the early stages, it must be considered in making predictions of the LCC more probabilistic. This study proposes a probabilistic LCC prediction model developed by applying the Monte Carlo simulation (MCS) to an LCC prediction model based on case-based reasoning (CBR) to support the decision-making process in the early stages of construction projects. The model was developed in two phases: first, two LCC prediction models were constructed using CBR and multiple-regression analysis. Through k-fold validation, one model with superior prediction performance was selected; second, a probabilistic LCC model was developed by applying the MCS to the selected model. The probabilistic LCC prediction model proposed in this study can generate probabilistic prediction results that consider the uncertainty of information available at the early stages of a project. Thus, it can enhance reliability in actual situations and be more useful for clients who support both construction and MRR costs, such as those in the public sector.
New Symmetric Differential and Integral Operators Defined in the Complex Domain
Authors: Ibrahim Rabha W. , Darus Maslina
Published: July 2019

The symmetric differential operator is a generalization operating of the well-known ordinary derivative. These operators have advantages in boundary value problems, statistical studies and spectral theory. In this effort, we introduce a new symmetric differential operator (SDO) and its integral in the open unit disk. This operator is a generalization of the Sàlàgean differential operator. Our study is based on geometric function theory and its applications in the open unit disk. We formulate new classes of analytic functions using SDO depending on the symmetry properties. Moreover, we define a linear combination operator containing SDO and the Ruscheweyh derivative. We illustrate some inclusion properties and other inequalities involving SDO and its integral.
Performance Analysis and Optimum Design of a Redundant Planar Parallel Manipulator
Authors: Wu Xiaoyong
Published: July 2019

This work presents a comprehensive performance evaluation and optimum design of a novel symmetrical 4-PPR (P indicates the prismatic joint, R denotes the revolute joint, and the letter with underline represents an active joint) redundant planar parallel manipulator. The kinematic model is established, upon which the inverse position and singularity are analyzed. Based on the evaluation of dexterity, velocity, and stiffness performance, the optimum region is achieved. With the optical design parameters, a case study for the analysis of dynamic behavior is conducted. Performance comparison between the redundant manipulator and another two non-redundant 3-PPR planar parallel manipulators, one with a Δ-shape symmetrical structure and the other with U-shape symmetrical structure, is presented. Simulation results reveal that the U-shape manipulator has the greatest velocity performance. Moreover, the redundant manipulator possesses the best dexterity, stiffness, and dynamic performance.
αD-Conotoxins in Species of the Eastern Pacific: The Case of Conus princeps from Mexico
Authors: Hernández-Sámano Arisaí C. , Falcón Andrés , Zamudio Fernando , Batista César V.F. , Michel-Morfín Jesús Emilio , Landa-Jaime Víctor , López-Vera Estuardo , Jeziorski Michael C. , Aguilar Manuel B.
Published: July 2019

Conus snails produce venoms containing numerous peptides such as the α-conotoxins (α-CTXs), which are well-known nicotinic acetylcholine receptor (nAChR) antagonists. Thirty-eight chromatographic fractions from Conus princeps venom extract were isolated by RP-HPLC. The biological activities of 37 fractions (0.07 µg/µL) were assayed by two-electrode voltage clamp on human α7 nAChRs expressed in Xenopus laevis oocytes. Fractions F7 and F16 notably inhibited the response elicited by acetylcholine by 52.7 ± 15.2% and 59.6 ± 2.5%, respectively. Fraction F7 was purified, and an active peptide (F7-3) was isolated. Using a combination of Edman degradation, mass spectrometry, and RNASeq, we determined the sequence of peptide F7-3: AVKKTCIRSTOGSNWGRCCLTKMCHTLCCARSDCTCVYRSGKGHGCSCTS, with one hydroxyproline (O) and a free C-terminus. The average mass of this peptide, 10,735.54 Da, indicates that it is a homodimer of identical subunits, with 10 disulfide bonds in total. This peptide is clearly similar to αD-CTXs from species of the Indo-Pacific. Therefore, we called it αD-PiXXA. This toxin slowly and reversibly inhibited the ACh-induced response of the hα7 nAChR subtype, with an IC50 of 6.2 μM, and it does not affect the hα3β2 subtype at 6.5 μM.
Co-Circulation of West Nile and Usutu Flaviviruses in Mosquitoes in Slovakia, 2018
Authors: Čabanová Viktória , Šikutová Silvie , Straková Petra , Šebesta Oldřich , Vichová Bronislava , Zubríková Dana , Miterpáková Martina , Mendel Jan , Hurníková Zuzana , Hubálek Zdeněk , Rudolf Ivo
Published: July 2019

Monitoring West Nile virus (WNV) and Usutu virus (USUV) activity now has the highest priority among mosquito-borne pathogenic viruses circulating in the European Union. This study documents a first time detection and the co-circulation of WNV lineage-2 (with the minimal prevalence of 0.46%) and USUV clade Europe 2 (with the minimal prevalence of 0.25%) in mosquitoes from the same habitat of south-western Slovakia and underlines necessity to perform rigorous surveillance in birds, mosquitoes, horses and humans in that country.
Current Situation and Perspectives on Hantaviruses in Mexico
Authors: Vigueras-Galván Ana L. , López-Pérez Andrés M. , García-Peña Gabriel E. , Rico-Chávez Oscar , Sarmiento-Silva Rosa E. , Suzán Gerardo
Published: July 2019

Hantaviruses are transmitted by rodents producing the hantavirus pulmonary syndrome (HPS) in the Americas. Today, no human cases of HPS have been reported in Mexico in spite of similar environmental conditions with Central America and the USA where several cases have occurred. To understand the current situation of hantaviruses in Mexico and the public health risk, a systematic review of studies was conducted reporting hantaviruses in rodents to known state seroprevalence and hantavirus genotypes. Simultaneously, this study identified the potential hantaviruses based on the phylogenetic diversity (PD) of hantaviruses reported in the Americas in hosts with the distribution in Mexico. A total 3862 rodents belonging to 82 species have been tested since 1999 to 2017. Overall, 392 individuals representing 43 rodent species were seropositive, and the seroprevalence ranged from 0 to 69.22%. Seven hantaviruses genotypes have been described in Mexico and three are zoonotic. Four host species of rodents are widely distributed in Mexico harboring the highest PD of viruses. According to the hosts distribution, 16 genotypes could be circulating in Mexico and some of these represent a potential risk for public health. This study proposed multidisciplinary and interinstitutional collaborations to implement systematic surveillance in rodents.
Design Optimization of Torsional Vibration Absorbers for Heavy-Duty Truck Drivetrain Systems
Authors: Berbyuk Viktor
Published: July 2019

In this paper, the feasibility of the application of a dual mass flywheel (DMF) for heavy-duty truck drivetrain systems was studied. The third engine order vibration harmonic was in the focus of analysis as one of the most significant contributions to the oscillatory response in the drivetrain systems of heavy-duty trucks. Global sensitivity analysis (GSA) and Pareto optimization were used for designing torsional vibration absorbers in an operating engine speed range of 600–2000 rpm. The optimization method attempted both to minimize the oscillations of the torque at the transmission input shaft and to maximize the energy efficiency of the vibration absorber. The GSA enabled the appropriate scanning of the domain of design parameters by varying all the parameters at the same time. It provided deep insight into the design process and increased the computational efficiency of the optimization. The results obtained show the following: the solution of the bi-objective optimization problem for torsional vibration absorbers does exist; Pareto fronts were obtained and analyzed for the DMF, presenting a trade-off between the measure of the attenuation of the oscillations of the torque at the transmission input shaft and the measure of the energy efficiency of the absorber; the optimized mass inertia, stiffness and damping parameters of a DMF do exist, providing the best attenuation of the torque oscillations; the performance of a DMF was further enhanced by incorporating a torsional tuned mass damper with appropriate optimized parameters. Finally, the results show evidence of the feasibility of the application of dual mass flywheels in heavy-duty truck drivetrain systems.
Trophic Patterns of Bighead Carp and Silver Carp Follow the Seasonality of Resource Availability
Authors: Yu Jia , Chen Jun , Deng Xuwei , Wu Zhixu , Yu Zuoming , Xu Jun , Su Haojie , Liu Jiarui , Wang Li , Wu Yao , Xie Ping
Published: July 2019

The influence of seasonality of the aquatic environment on food web has been notoriously understudied in empirical ecology. In this study, we focus on seasonal changes in one key attribute of a food web, the trophic level. We determine whether seasonal variations of fish trophic levels could be indicated by the change in food resources. Silver carp (Hypophthalmichthys molitrix) and bighead carp (H. nobilis) were used to explore the responses of trophic levels of the filter-feeding fish to seasonal variations of food resources. Combined stable isotopic analysis and dietary analysis revealed that filter-feeding fish tended to have a higher trophic level in spring (May) and autumn (September and October). This may result from the abundant density of food resources (zooplankton and phytoplankton) and fish flexible foraging strategy, as we predicted that the trophic level follows the seasonality of food availability. Pearson’ correlation analysis and a structural equation model showed that seasonal variation of total phosphorus and water temperature could indirectly affect trophic levels of silver carp and bighead carp by mediating the abundance of phytoplankton and zooplankton directly and indirectly along the food chain. According to these findings, the seasonal variation of food resources could be an important indicator of the temporal dynamics of the food web trophic pattern in freshwater ecosystems.
Estimating Pollutant Residence Time and NO3 Concentrations in the Yucatan Karst Aquifer; Considerations for an Integrated Karst Aquifer Vulnerability Methodology
Authors: Martínez-Salvador Carolina , Moreno-Gómez Miguel , Liedl Rudolf
Published: July 2019

Karst aquifers are a major source of drinking water with intrinsic features that increase the pollution risk from anthropogenic and natural impacts. In Yucatan, Mexico, groundwater is the sole source of drinking water, also acting as receptor of untreated wastewater due to the low regional coverage of sewer systems. To protect karst groundwater, vulnerability methodologies are widely used. Worldwide, multiple karst vulnerability schemes have been developed and tested; however, none of these consider pollutant residence time or pollutant concentration as core parameters to estimate vulnerability. This work aims to define important considerations regarding the behavior of nitrates (NO3) in a real scenario, to be included in a new integrated vulnerability method. This work has two main objectives: to set up a groundwater model to depict as close as possible the groundwater behavior of the Yucatan karst system, and to introduce a transport model to estimate the behavior of a pollution plume. Model outcomes suggest that pollutants have a short residence time, reaching the coast in the north after 3 years. Well fields are also affected by pollution at variable NO3 concentrations. Results can be further discretized to establish a base and to include these parameters as part of a new integrated groundwater vulnerability approach.
Pretreatment Techniques for Produced Water with Subsequent Forward Osmosis Remediation
Authors: Liden Tiffany , Hildenbrand Zacariah L. , Schug Kevin A.
Published: July 2019

Unconventional oil and gas extraction is on the rise across the United States and comprises an integral component in meeting the nation’s energy needs. The primary by-product of this industrious process is produced water, which is a challenging matrix to remediate because of its complex physical and chemical composition. Forward osmosis is a viable option to treat high-salinity produced water; however, fouling has been an issue. This study aimed to treat produced water before using forward osmosis as a remediation option. Trials consisted of a series of five experiments in order to evaluate the performance of the membrane. Samples were treated by centrifugation, activated carbon, filtration, ferric chloride, as well as coagulants and a polymer. It can be concluded that forward osmosis can be used to extract water from high-salinity oil field brines and produced water, and that pretreating the produced water decreased the tendency for fouling. The pretreatment with the overall best performance was activated carbon, which also yielded the lowest total organic carbon concentrations of 1.9 mg/L. During remediation trials using produced water pretreated with activated carbon as the feed solution, there was a 14% decrease in flux over the course of the 7 h trials. The membrane performance was restored after washing.