bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Cybervictimization on the Self-Management of Chronic Conditions: Lived Experiences
Authors: Alhaboby Zhraa A , Evans Hala , Barnes James , Short Emma
Published: July 2023

Background

Cybervictimization of people with long-term conditions is a disturbing phenomenon with a documented impact on health and well-being. These experiences are primarily examined using quantitative methods, focusing on children and young people. However, research centered on the cybervictimization of adults with chronic conditions is scarce, with limited qualitative input from the victims as experts in their own experiences.

Objective

This study aims to understand the impact of cybervictimization on the self-management of long-term conditions among adults with chronic conditions and disabilities in the United Kingdom.

Methods

This paper reports the findings from the qualitative phase of a phenomenologically informed mixed methods study. The biographical disruption concept was used to conceptualize the study. In-depth semistructured interviews were conducted with 13 participants with chronic conditions who experienced cybervictimization. A codebook was developed, and a zigzag approach to thematic analysis was used to define and refine themes. Ethical considerations and risk assessment were ongoing during the research process because of the sensitivity of the topic and cases of harassment.

Results

Cybervictimization has direct and indirect impacts on the self-management of chronic conditions. This impact was verified across 6 overarching themes that emerged from this study. First, biomedical events included overall health deterioration because of existing conditions, new diagnoses, and subjective physical complaints. Second, the impact on mental health was perceived through psychological consequences and psychiatric disorders that developed after or during this traumatic experience. Third, the multilevel impact theme focused on disrupting the strategies for coping with health conditions and involved unplanned changes to victims’ health management priorities. Fourth, the impact of complexity reflected the perceived uniqueness in each case, intersectionality, struggle to obtain formal support, and subsequent health complications. Fifth, social network involvement comprised the effects of social isolation, victim blaming, and deception. Finally, the disability discrimination theme focused on prejudice, issues on inclusion, and hostility in society, with subsequent effects on well-being.

Conclusions

People with long-term conditions experienced different forms of cybervictimization, all disruptive with various effects on health. Disability discrimination was a prominent finding to be further investigated. This paper reports the impact as themes to guide further research and practice, with the recognition that long-term conditions and impairments are not a homogeneous group. Despite the devastating consequences, there are positive points that strengthen potential interventions. Awareness-raising campaigns, training of support channels, and multidisciplinary research are recommended to tackle this issue and initiate change.
Data Quality in Health Research: Integrative Literature Review
Authors: Bernardi Filipe Andrade , Alves Domingos , Crepaldi Nathalia , Yamada Diego Bettiol , Lima Vinícius Costa , Rijo Rui
Published: July 2023

Background

Decision-making and strategies to improve service delivery must be supported by reliable health data to generate consistent evidence on health status. The data quality management process must ensure the reliability of collected data. Consequently, various methodologies to improve the quality of services are applied in the health field. At the same time, scientific research is constantly evolving to improve data quality through better reproducibility and empowerment of researchers and offers patient groups tools for secured data sharing and privacy compliance.

Objective

Through an integrative literature review, the aim of this work was to identify and evaluate digital health technology interventions designed to support the conducting of health research based on data quality.

Methods

A search was conducted in 6 electronic scientific databases in January 2022: PubMed, SCOPUS, Web of Science, Institute of Electrical and Electronics Engineers Digital Library, Cumulative Index of Nursing and Allied Health Literature, and Latin American and Caribbean Health Sciences Literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and flowchart were used to visualize the search strategy results in the databases.

Results

After analyzing and extracting the outcomes of interest, 33 papers were included in the review. The studies covered the period of 2017-2021 and were conducted in 22 countries. Key findings revealed variability and a lack of consensus in assessing data quality domains and metrics. Data quality factors included the research environment, application time, and development steps. Strategies for improving data quality involved using business intelligence models, statistical analyses, data mining techniques, and qualitative approaches.

Conclusions

The main barriers to health data quality are technical, motivational, economical, political, legal, ethical, organizational, human resources, and methodological. The data quality process and techniques, from precollection to gathering, postcollection, and analysis, are critical for the final result of a study or the quality of processes and decision-making in a health care organization. The findings highlight the need for standardized practices and collaborative efforts to enhance data quality in health research. Finally, context guides decisions regarding data quality strategies and techniques.

International Registered Report Identifier (IRRID)

RR2-10.1101/2022.05.31.22275804
Exploring Telewellness: A Mixed-Method Approach to Health Perceptions and Practices of a Livestream Virtual Fitness Class (Preprint)
Authors: Ahumada Veronica , Wood Taffeta Star , Satake Noriko , Marcin James
Published: July 2023

BACKGROUND

During early COVID-19, employees, and community members lacked access to fitness classes due to the elevated risk of infection and access to exercise facilities. An online, synchronous, physical fitness class was delivered via videoconferencing to create a sense of community and promote physical and mental wellness among healthcare workers and community members. Participants were recruited via faculty/staff listservs and instructor email list. Classes were taught by a faculty member at an academic medical center.

OBJECTIVE

This study examines the perceived mental and physical health benefits of attending an online, synchronous, physical fitness class for healthcare workers and community members. We also assess the feasibility and functionality of related technologies necessary for delivering and attending livestream fitness classes.

METHODS

Descriptive data were collected using an online participant survey that included quantitative and qualitative analyses to evaluate the ongoing, online exercise class. These data were collected via one survey during November and December of 2022.

RESULTS

51 participants were recruited and 100% completed the participant questionnaire. Survey participants consisted of 28 employees (55%), 17 non-employees (33%), and 6 declined to state (12%). High overall exercise class satisfaction was observed in the survey responses (mean 4.0 out of 5, SD=1). Survey analyses revealed significant perceived value of mental and physical health benefits as motivating factors for taking livestreamed physical fitness class.

CONCLUSIONS

Results provide preliminary support for the use of online videoconferencing platforms to facilitate synchronous fitness classes for employees and associated community members. Future studies should continue to explore perceived benefits, including mental and physical wellness.
Sensitivity and specificity of the method of acoustic diagnosis of pneumonia using the acoustic monitoring device Trembita-Corona
Authors: Marushko Yu.V. , Khomych O.V.
Published: July 2023

Background. Diagnosis of pneumonia is difficult and requires a comprehensive examination. Respiratory acoustics is currently a promising diagnostic method. The purpose was to evaluate the possibility of pneumonia detection by the average signal power, frequency and amplitude of the acoustic signal using the Trembita-Corona acoustic monitoring device. Materials and methods. Onу hundred and ninety-three children aged from 1 month to 18 years were examined. The children were divided into two groups: group I — 98 patients with community-acquired pneumonia, group II — 95 healthy children. All children were examined using the Trembita-Corona acoustic monitoring device. Results. The sensitivity of the method for detecting pneumonia using the acoustic monitoring device Trembita-Corona according to the average signal power in the 4th, 5th and 6th octaves is from 90.8 to 99 %, and the specificity is from 87.4 to 100 %. The sensitivity of the method for detecting pneumonia using the acoustic monitoring device Trembita-Corona according to the frequency of the acoustic signal in the 3rd and 5th octaves is more than 60 %, and the specificity is more than 63 % in the 3rd octave and 100 % in the 5th octave, respectively. The sensitivity of the method for detecting pneumonia using the acoustic monitoring device Trembita-Corona according to the amplitude of the acoustic signal in the 4th, 5th and 6th octaves is 88.9, 99.9 and 86.9 %, respectively, and the specificity is 100 % in the 4th and 5th octaves and 87.4 % in the 6th octave. Conclusions. The acoustic monitoring device Trembita-Corona demonstrates high specificity, sensitivity and positive predictive value and negative predictive value at given prevalence.
Comorbidity in children with rheumatic diseases: literature review and 10-year experience of own research
Authors: Bogmat L.F. , Shevchenko N.S. , Holovko T.O. , Nikonova V.V. , Bessonova I.M. , Akhnazariants E.L. , Fadieieva A.О.
Published: July 2023

Background. A decrease in the age of onset of rheumatic diseases in children, an increase in the total duration of the disease, the development of persistent functional and organic di­sorders of organs and systems determine the need to study comorbid conditions already in childhood in order to optimize their diagnosis and comprehensive therapy. The purpose was to study the frequency and main patterns for the formation and further progression of comorbidities in children with rheumatic diseases (juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE)). Materials and methods. An analytical review of the literature on the prevalence and diagnosis of comorbid lesions in adult patients with rheumatic diseases and in children was carried out; 250 children aged 3–18 years with JIA and 67 children with SLE with a juvenile onset were dynamically monitored for the presence of comorbid conditions of the cardiovascular system, kidneys, lungs, eyes, bone tissue, blood lipid disorders. Results. The frequency and nature of comorbidity in children with JIA and SLE have been determined. Preservation of the process activity is the main factor in the progression of comorbid pathology and the formation of irreversible damage to organs and systems with the development of their failure and violations of the quality of life of patients. Conclusions. Based on the presented materials, it is possible to develop programs to prevent the formation and progression of irreversible damage to systems and organs that occur under comorbid conditions in children with rheumatic diseases and to effectively socialize these children.
CLINICAL AND ETIOLOGICAL PROFILE OF ACUTE FLACCID PARALYSIS IN CHILDREN
Authors: AGARWAL VIJAY , JAIN PANKAJ KUMAR , JAIN BALKISHAN
Published: July 2023

Objective: This study was conducted to determine the clinical characteristics and differential diagnosis of individual cases of acute flaccid paralysis (AFP) reporting to tertiary care teaching hospital of Jaipur.
Methods: This prospective observational study was conducted among patients attending outdoor, indoor, and neurology clinics with provisional diagnosis of AFP. The diagnosis was based on the available clinical data, vaccination status, and laboratory results (stool examination, arterial blood gas analysis, thyroid profile, serum electrolytes, electrophysiological studies, cerebrospinal fluid analysis, urinary pH, and imaging).
Results: A total of 60 patients were evaluated over a study duration of 1 year. About 81.7% were male. Most common presenting complaint was lower-limb weakness (100%). None of the cases were identified as acute poliomyelitis or polio-compatible. Guillain–Barré syndrome (GBS) was the most common cause of non-poliovirus AFP (75%). Most common nerve conduction velocity findings in our study were bilateral motor axonal affection of common peroneal nerve (55%).
Conclusion: The most common cause of AFP was GBS in all age groups. No case was diagnosed as poliomyelitis. All of the patients of GBS had progressive muscle weakness in a roughly symmetrical distribution, with areflexia of lower limbs.
COMPARITIVE STUDY OF DENDRITIC CELL VACCINE PREPARATION WITH PRESENCE AND ABSENCE OF MALPIGHIA EMARGINATA FRUIT EXTRACT USING TUMOR RNA TRANSFECTION METHOD: A PROMISING APPROACH FOR PROSTATE CANCER
Authors: K KOTEESWARAN , P NATARAJAN
Published: July 2023

Acerola (Malpighia emarginata DC) is the richest natural source of ascorbic acid and also contains a plethora of phytonutrients such as flavonoids, anthocyanins, carotenoids, and phenolics. By using the fruits of Malpighia emarginata, are used for the treatment of cancer by inducing effective anti-tumor immunity through dendritic cells. Dendritic cells (DC) are the heterogeneous population of antigen-presenting cells that invade tumors. They play an important role in the priming and maintenance of local immunity, and their major function is diminished by some factors encountered in the local environment. For the success of cancer immunotherapy, adequate tumor-specific antigens play a very important role in inducing a tumor-specific immune response by effective delivery of these antigens. In this proposal, by using these strategies, mature and immature dendritic cells were obtained in-vitro by adding specific cytokines to monocyte cell culture containing Malpighia emarginata fruit extract in the presence of prostate-specific antigen (PSA), and their results were compared to those obtained without the presence of Malpighia emarginata fruit extract. In the prostate tumor lineage, the RNA is extracted into the cell by electroporation, and the transfection success was measured by immunocytochemistry of the PSA expression level in dendritic cells. For the comparative study of in-vitro RNA transcription, this method allows small tumors to be used for dendritic cell vaccine preparation through the activation of DC by in the presence and absence of Malpighia emarginata fruit extract and it is a promising approach for the treatment of metastatic prostate cancer.
EVALUATION OF THE ACUTE AND CHRONIC TOXICITY OF THE ETHANOLIC EXTRACT OF ABELMOSCHUS ESCULENTUS INSWISS ALBINO MICE
Authors: CHENOLY SHABINA KOMATH , C SHANKARAPPA , PINNELLI VENKATA BHARATKUMAR
Published: July 2023

Objectives: This work aimed to evaluate the acute and chronic toxicity of the ethanolic extract of Abelmoschus esculentus, administered orally to Swiss albino mice.
Methods: An dosage of 2000 mg/kg was administrated and toxicity studies were conducted following organization for economic cooperation and development guidelines of 425 and 407 respectively in Swiss albino mice. During the study, general signs of toxicity were monitored. The mice which are used in the toxicology study were sacrificed, and histological, hematological, and biochemical analyses were done.
Results: No behavioral changes were observed in all mice subjected to the study. The extract did not bring about any deaths after 14 days for the acute toxicity study in all the doses and also 90 days at a very high dosage chronic toxicity study days. Although a significant variation was observed in hematocrit, granulocyte, lymphocyte, Alanine transaminase, total cholesterol levels, and blood glucose levels, the extract did not have any significant effect (p<0.05) on the other biochemical and hematological parameters evaluated during the study.
Conclusion: The result indicates that the oral administration of ethanolic extract of A. esculentus did not produce any significant toxic effect in the mice. Hence, the extract can be utilized safely for therapeutic use in pharmaceutical formulations.
A CLINICAL PROSPECTIVE STUDY OF CHRONIC PANCREATITIS
Authors: G Purushotham , P Himabindhu , P Gowthami , M Jahnavi
Published: July 2023

Introduction: Chronic pancreatitis (CP) is a relentlessly progressive fibroinflammatory process, resulting in the destruction of endocrine and exocrine elements, which may eventually lead to pancreatic insufficiency. Although previous reports on the treatment of CP have yielded considerable data, our study hopes to give validation on managing CP patients conservatively with confidence.
Aim: A prospective study of CP.
Methods: This study was conducted in the Department of General Surgery, SVRRGGH, affiliated with Sri Venkateswara Medical College Tirupati. The materials for the study were collected from patients presenting to the surgery outpatient department and emergency room with the features of CP during the period of March 2020–April 2021 were included in the study.
Results: The incidence is high in patients of age group 44.46±9.16, of which 63.3% were males and 36.7% were females. The most common presenting symptom was pain abdomen. All the data were statistically analyzed using software, namely SPSS 21.0 and Instat. Microsoft Word and Excel have been used to generate tables and graphs. Results on continuous measurements are presented on Mean±SD, and results on categorical measurements are presented in number (%).
Conclusion: Conservative management shows 100% pain relief, 33.3% had steatorrhea, while surgical management shows 80% pain relief and 80% steatorrhea. Hence patients with CP can be treated effectively with conservative management.
TO COMPARE INTRAVENOUS FERRIC CARBOXYMALTOSE VERSUS INTRAVENOUS IRON SUCROSE IN POST-PARTUM WOMEN WITH IRON-DEFICIENCY ANEMIA
Authors: Karwasara Vishakha , Prakash Parul , Datika Sandeep , Goyal Priya
Published: July 2023

Objectives: The objective of this study was to compare intravenous ferric carboxymaltose (FCM) versus intravenous iron sucrose in post-partum women with iron-deficiency anemia (IDA).
Methods: This was a hospital-based prospective randomized controlled study, comprising 100 post-natal women with IDA with hemoglobin level <11 g/dL admitted in post-natal ward of the Obstetrics and Gynecology Department in SP Medical College, Bikaner, from June 2021 to May 2022.
Results: In age, residence, socioeconomic status, the incidence of IDA in both the groups were comparable and is more among rural areas, low socioeconomic status. Improvement in hemoglobin, serum ferritin, and blood indices in both the iron sucrose and FCM groups, but it was faster and greater with ferric carboxymaltose when compared with iron sucrose. Other advantages are large dose administration at 1 time, therefore, lesser total number of doses required in the FCM group as compared to the IS group.
Conclusion: FCM is well tolerated, safer, and effective than iron sucrose in treatment of post-natal IDA.
Medicinal Plants and Their Active Compounds: Potential Candidates for the Management of COVID-19
Authors:   College of Agriculture, Jawaharlal Nehru Krishi Vishwavidyalaya, Ganj Basoda, Vidisha, (M.P.) 464221, Kumari Aradhna , Singh Santosh Kumar ,   Department of Soil Science, Dr Rajendra Prasad Central Agriculture University, Pusa, Samastipur,, Mishra Rashmi ,   SAM Girls College, Ashoka Garden, Raisen Road, Bhopal, (M.P.) 462043, Kulshrestha Mohita , Chaurasia Abhilasha , Raghuvanshi Swati
Published: July 2023

This book chapter discusses the potential of medicinal plants in combating COVID-19. The chapter highlights several medicinal plants' anti-inflammatory, antimicrobial, and immune-boosting properties such as ginger, turmeric, garlic, echinacea, licorice root, and elderberry. The chapter also emphasizes the need for more research to determine these medicinal plants' effectiveness and proper dosage in treating COVID-19. We conclude that medicinal plants may have potential as candidates for managing COVID-19, and it is crucial to consult healthcare professionals before using them as a treatment for COVID-19 or any other health condition.
The Effects of COVID 19 Pandemic to the Public Health Sector: Case Study-Canada
Authors: Ojong Yvonne Bessem
Published: July 2023

The COVID-19 pandemic has impacted every aspect of our lives, including the public health sector. In Canada, this crisis has challenged the healthcare industry in unprecedented ways, from managing surging cases to ensuring access to essential medical supplies. As we continue navigating through these uncertain times, it’s important to take a closer look at how the Canadian public health sector is responding and adapting to these new challenges. Join us as we dive into a case study on the effects of COVID-19 on Canada's public health system and explore lessons learned along the way.
Coronavirus (COVID-19) Origin: How it Spreads, Their Challenges, and the Way People Deal with Pandemic around the World
Authors: Singh Nidhi , Bashir Shazia , Singh Pooja
Published: July 2023

The 2019–2020 coronavirus pandemic is upending life on a global level as we know it. The highly infectious coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first seen in Wuhan, Hubei, China, where its outbreak was first identified in December 2019. After almost three months, on March 11, 2020, the World Health Organization (WHO) recognized it as a pandemic considering its significant ongoing spread in multiple countries across the world. COVID-19 is characterized by a variety of symptoms, including fever, cough, congestion, fatigue, shortness of breath, headache, sore throat, nausea or vomiting, loss of smell or taste, and body aches. COVID-19 may progress to severe respiratory illness, with symptoms of chest pain and extreme difficulty in breathing, requiring hospitalization. The coronavirus disease 2019 is profoundly affecting lives around the globe. There are numerous mental health threats associated with the current pandemic and subsequent restrictions. Besides worries and anxieties related to COVID-19, the economic situation has worsened with high and rising levels of unemployment in all affected countries. In response to the global pandemic, under- Innovare Academic Sciences Pvt Ltd COVID-19 Pandemic Challenges and Innovations 77-94 resourced doctors are also facing unprecedented challenges. Research and case studies have shown that lockdowns were generally effective at decreasing the spread of COVID-19.
Central Bank Responses to Coronavirus Pandemic in Europe
Authors: Bace E.
Published: July 2023

Beginning in January 2020, the spread of the coronavirus in Europe picked up quickly, forcing several European governments, like most other affected countries, to enact “lockdown” measures. This led many businesses to close, at least temporarily, especially those in the restaurant, leisure, travel, and retail industries. Due to the lengthy lockdown period—which lasted for months—many enterprises failed and others suffered large losses, resulting in a sharp decline in GDP over the following few years. Consumer spending and investment also fell sharply, and despite government efforts to help, the problem’s size and limited resources have made a recovery time-consuming. This study aims to discuss and evaluate the numerous activities supported by financial regulators and central banks in Europe and the US to raise financial institutions’ understanding of the tools and resources at their disposal during the challenging pandemic conditions. We assemble a list of these programs that the Bank provides for International Settlements (BIS), the European Central Bank (ECB), the Bank of England (BOE), and the Federal Reserve (Fed) in the United States. After outlining these categories, we provide some conclusions and suggestions for best practises among treasury departments in financial institutions that must comply with this rule.
Impact of Lockdown on Wildlife Habits and Habitats
Authors: Saini Yashika , Singh Sonalika
Published: July 2023

The COVID-19 pandemic triggered extensive lockdown measures worldwide, resulting in an unforeseen halt to human activities. This chapter highlights the positive impact of the COVID-19 lockdown on wildlife habits and habitats, showcasing the ecological benefits observed during this period. During the lockdown, reducing human-induced disturbances, such as noise pollution, habitat destruction, and air pollution, created an environment conducive to wildlife well-being. With limited human presence and reduced vehicular traffic, several wildlife species experienced reduced stress levels and increased opportunities for natural behavior. Wildlife populations near urban areas benefited from decreased noise pollution, allowing for improved communication, breeding success, and foraging efficiency. Additionally, diminished air pollution levels contributed to enhanced visibility, enabling better navigation and foraging for species reliant on visual cues. The reduced human presence in ecologically sensitive areas allowed certain wildlife species to explore and reclaim territories previously dominated by human activities. Animals with larger home ranges, such as large mammals and birds, ventured into urban environments, which provided them with novel resources and expanded their distribution. This shift in behavior provided valuable insights into the adaptability and resilience of wildlife. Furthermore, the temporary closure of nature reserves and protected areas due to lockdown restrictions provided a reprieve for wildlife populations. With limited disturbance from tourism and recreational activities, vulnerable species had an opportunity to breed, forage, and rest without human interference. This respite allowed for the recovery of stressed populations and the restoration of natural ecological Innovare Academic Sciences Pvt Ltd COVID-19 Pandemic Challenges and Innovations 130-141 processes. Although the positive impacts of the COVID-19 lockdown on wildlife habits and habitats were notable, it is essential to recognize that these benefits were temporary and contingent upon the duration and severity of lockdown measures. As societies gradually return to normalcy, it is crucial to implement sustainable practices that minimize the negative impacts of human activities on wildlife and their habitats. Understanding the positive ecological outcomes of the COVID-19 lockdown on wildlife provides valuable lessons for conservation strategies and emphasizes the need to balance human development and environmental protection. Incorporating these lessons into future planning and decision-making can help mitigate the human footprint on ecosystems and contribute to the long-term well-being of wildlife and their habitats.
The Inimitable Sociologist: Revisiting Georg Simmel's Seminal Texts
Authors: George Kevin
Published: July 2023

In 1858, Georg Simmel was born in Berlin. The conflicts of Germany's unique road to modernity were best exemplified by that metropolis. Financial speculation and rapid urbanisation fueled Berlin's ascent to global prominence. While a young proletariat (Georg Simmel) fought the government and the bourgeoisie for political and economic rights, an avant-garde cultural elite coexisted uncomfortably with the central European aristocracy. The landed Prussian Junker aristocracy, the cornerstone of Bismarck's unified German Reich, was eroded because of the proliferation of modern technologies that created power and riches. The Hohenzollern dynasty, one of the oldest in Europe, ruled over a tumultuous realm while being enamoured with the most contemporary concepts.
Cryptographic Method to Enhance the Data Security using ElGamal Algorithm and Sumudu Transform
Authors: Thakkar Akash , Gor Ravi
Published: July 2023

Abstract: Cryptography is the science of using mathematics to encrypt and decrypt data. Cryptography includes two phases: Encryption and Decryption. Encryption is the process of transforming plaintext to ciphertext, whereas decryption is the reverse procedure. Encryption and decryption schemes based on Sumudu Transform are unable to give more security while communicating the information. ElGamal is a public key algorithm that is based on the discrete logarithm problem. The purpose of this study is to introduce a cryptographic method that uses the ElGamal algorithm and Sumudu Transform to improve communication security.
A Study of Performance Measures and Throughput of Raft Consensus Algorithm
Authors: Vora Stuti , Thakkar Nidhi , Gor Ravi
Published: July 2023

Abstract: Due to its decentralised structure, blockchain technology has acquired great traction in fields such as banking, business, healthcare, and e-voting due to its decentralised nature. Because of the difficulty of lesser throughput, many blockchain systems have sought efficiency enhancements. Mathematical models such as Markov processes, queuing theory, and game theory are employed to analyze various aspects of blockchain systems, including mining processes, consensus mechanisms, and overall performance. This paper focuses on using M/M/1 queuing theory to analyze blockchain mining processes, utilizing the Raft algorithm for consensus. A simulation done by using python is also provided
Navigating Hole Cleaning and Drilling Challenges in High-Angled Wells with D-Max Enhanced Water-Based Mud System: A Comparative Experimental Analysis
Authors: Joseph Victor Chukwudi , Nwosu Awa
Published: July 2023

Abstract: Effective hole cleaning is one of the biggest challenges faced in drilling operations all over the world, if a wellbore is not properly cleaned, it could lead to lots of hole problems, hole collapse, stuck pipe, mud losses, low ROP, casing issues, poor cementing etc. The impact of poor hole cleaning could lead to a ballooned well cost, in some cases, loss of the well and operator investment. Therefore, it is very imperative to carefully select drilling fluids system that will enable efficient hole cleaning for drilling activities. Selecting the appropriate fluid system that will guarantee effective hole cleaning requires a high level of engineering fluid designs and formulations.
The Effect of Transformational Leadership on Job Satisfaction Mediated by Organizational Citizenship Behavior (OCB)
Authors: Ningsih Tran Sida Yulia , Irawati Sandra , Fuadiputra Iqbal ramadhani
Published: July 2023

This study aims to determine how transformational leadership influences employee performance, and whether OCB variables can mediate the relationship between transformational leadership style and employee performance. This research was conducted on employees of the General Sector of the Probolinggo Regency Food Security and Agriculture Service with a total of 30 respondents. The sampling technique in this study used saturated sampling where all populations were sampled. Data collection in this study used a questionnaire which was analyzed with a scale range and Partial Least Square (PLS) 4.0. The results of calculating this scale range show that transformational leadership is at a high level, employee performance is in the high category, and Organizational Citizenship Behavior is in the strong category. The results of this study indicate that transformational leadership has a positive and significant effect on employee performance. Transformational leadership has a positive and significant effect OCB. Organizational citizenship behavior (OCB) has a positive and significant effect on employee performance and is able to mediate the effect of the relationship between transformational leadership on employee performance.
The Effect of Training and Work Environment on Employee Performance with Job Satisfaction as Moderating Variable at PT Karsa Mulia Sejahtera Balikpapan
Authors: Fadilah Muhammad Fernanda , Asfiah Nurul , Roz Kenny
Published: July 2023

The aim of this study is to determine if training and workplace environment have an impact on employee performance with job satisfaction acting as a moderating variable. This type of study employs a quantified approach and a 40-person sample size. Information was gathered by handing out surveys (primary data). The statistics in this research are examined using path analysis. According to research findings, training has a positive but not statistically significant effect on employee performance, job satisfaction has a positive and statistically significant effect on employee performance, and work environment has a positive and statistically significant effect on employee performance. However, job satisfaction is unable to moderate either of these effects on employee performance.
A CO-CREATED PROJECT OF LEGAL DESIGN AND VISUAL LAW APPLIED TO INTERNATIONAL ENVIRONMENTAL LAW: TRANSFORMATION OF THE ESCAZÚ AGREEMENT AND ENVIRONMENTAL ACCESS RIGHTS INTO VISUAL MATERIALS FOR AND WITH THE CHIQUITANO PEOPLE
Authors: Parola Giulia , Chue Muquissai Silvano , Paola Poto Margherita
Published: July 2023

Legal Design (LD) and Visual Law (VL) are two instruments that can be used in favor of elaborating on clearer and more transparent, and adequate legal solutions for the law recipients, the legal entities, and society at large. This article will explain the project “Legal Design and Visual Law in International Environmental Law: Conversion of the Escazú Agreement into Visual Materials for and with the Chiquitano People”. The objective of the project was to teach students, in practice, an efficient method to create understanding and engagement in Environmental Law. Simultaneously, the project aimed to support the coproduction of didactic materials for and with the Chiquitano people, which could act as a tool for strengthening environmental participation. This paper also aims to outline the different steps of the project by clarifying the methods and methodology of co-creation used. The article is divided into 3 sections: an overview of the concepts of LD and VL (section 1), the requisite steps LD and VL (section 2) and lastly, the paper demonstrates how these steps have been applied to the co-creation of the comic book (section 3).
IMPACTO DO PROGRAMA BOLSA FAMÍLIA NA EXTREMA POBREZA E POBREZA NO MEIO RURAL E URBANO DAS GRANDES REGIÕES BRASILEIRAS DE ACORDO COM A PNAD CONTÍNUA DE 2019
Authors: Hespanhol de Souza Luana , Gomes Ney Marlon
Published: July 2023

O Programa Bolsa Família (PBF) foi criado em 2003 e se tornou a principal política nacional de combate à pobreza até sua substituição, em 2021, pelo Auxílio Brasil. Pensando nas contribuições do PBF nos últimos anos, o artigo tem como objetivo central compreender o papel do programa na redução da extrema pobreza e pobreza através dos dados da Pesquisa Nacional por Amostra de Domicílios Contínua (PNADC) do IBGE, de 2019. Os resultados mostram que o benefício do PBF é muito importante para aqueles que se encontram na extrema pobreza, mas em algumas situações o valor recebido eleva as famílias da linha de extrema pobreza para a linha de pobreza. Não se pode negar as contribuições positivas que o programa alcançou, contudo é necessário pensar em estratégias que possibilitem a permanência dos beneficiários acima das linhas de pobreza e extrema pobreza.
A novel semi-resolved CFD-DEM method with two-grid mapping:methodology and validation
Authors: Che Hanqiao , Windows-Yule Christopher , O'Sullivan Catherine , Seville Jonathan
Published: July 2023

The semi-resolved CFD-DEM method has emerged as a prominent tool for
modelling particle-fluid interactions in granular materials with high
particle size ratios. However, challenges arise from conflicting
requirements regarding the CFD grid size, which must adequately resolve
fluid flow in the pore space while maintaining a physically meaningful
porosity field. This study addresses these challenges by introducing a
two-grid mapping approach. Initially, the porosity field associated with
fine particles is estimated using a coarse CFD grid, which is then
mapped to a dynamically refined grid. To ensure conservation of total
solid volume, a volume compensation procedure is implemented. The
proposed method has been rigorously validated using benchmark cases,
showing its high computational efficiency and accurate handling of
complex porosity calculations near the surface of coarse particles.
Moreover, the previously unreported impact of the empirical drag
correlation on fluid-particle force calculations for both coarse and
fine particles has been revealed.
EXPERIMENTAL INVESTIGATION ON SHAPE SEGREGATION OF 3D PRINTED PARTICLES USING A FT4 FREEMAN RHEOMETER
Authors: Shekhar Shishir , Tuohey Joshua , Pereira Gerald , Hapgood Karen , Morton David , Cleary Paul
Published: July 2023

This study examines how granular mixtures of differently shaped
particles segregate in a Freeman (FT4) rheometer. The mixtures contained
two sets of particles with varying shapes and relative sizes. While our
main focus was on the effect of particle shape on segregation, we
recognized that even slight differences in size could lead to
segregation. We specifically investigated when particles of different
shapes have the same effective size, exploring three cases: 1) the
largest sphere within a cubic particle (inscribed sphere), 2) the
smallest sphere enclosing a cubic particle (circumscribed sphere), and
3) a sphere and cube with equal volume. Our findings reveal that binary
mixtures of cubical and spherical particles can significantly segregate
radially in the bed. We propose that the primary mechanism for this
radial segregation is percolation caused by radial centrifugal forces
pushing the particles outward.
Localized expression of the olfactory receptor genes in the olfactory organ of common minke whales
Authors: Hirose Ayumi , Nikaido Masato , Nakamura Gen , Fujise Yoshihiro , Kato Hidehiro , Kishida Takushi
Published: July 2023

Baleen whales (Mysticeti) possess the necessary anatomical structures
and genetic elements for olfaction. Nevertheless, the olfactory receptor
gene (OR) repertoire has undergone substantial degeneration in the
cetacean lineage following the divergence of Artiodactyla and Cetacea.
The functionality of the highly degenerated mysticete ORs within their
olfactory epithelium remains unknown. In this study, we extracted total
RNA from the nasal mucosa of common minke whales (Balaenoptera
acutorostrata) to investigate the localized expression of ORs. All
three sections of the mucosae examined in the nasal chamber displayed
comparable histological structure, whereas the posterior portion of the
frontoturbinal region exhibit notably high expression of ORs and another
gene specific to the olfactory mucosa. Neither the olfactory bulb nor
the external skin exhibited expression of these genes. Although this
species possesses four intact class-1 ORs, all the ORs expressed in the
nasal mucosa belong to class-2, implying the loss of aversion to
specific odorants. These anatomical and genomic analyses suggest that
ORs are still responsible for olfaction within the nasal region of
baleen whales, enabling them to detect desirable scents such as prey and
potential mating partners.
Resilient dual-mode model predictive control for constrained linear networked control systems with random DoS attacks
Authors: Wu Zongze , Qiu Li , Lin Shaolie , Chen Runjie , Teng Jie , Najariya Marzieh
Published: July 2023

This paper proposes a resilient dual-mode model predictive control (MPC)
framework that simultaneously considers system constraints and
Denial-of-Service (DoS) attacks for linear time-invariant networked
control systems (NCS). The DoS attacks is random and occurs at the both
sensor-to-controller ( S - C ) communication channel and
controller-to-actuator ( C - A ) communication channel. The MPC can well
compensate the effect of the DoS attacks on the constrained system. At
the same time, to address the problem of repeated oscillations caused by
the inaccurate model near the equilibrium point of the MPC, and to
reduce the computational effort, the resilient two-mode MPC is used. To
guarantee the stability of NCS, a resilient terminal invariant set based
on LMI is designed to ensure that the constrained system remains stable
under M consecutive attacks. Finally, numerical simulations are
conducted to validate the proposed MPC framework, showing its
effectiveness in practical applications.
Perspective and Opportunity for forensic integrative genomics in the Human Pangenome Reference sequence era
Authors: He Guanglin , Huang Yuguo , Chen Jing , Wang Zhiyong , Li Xiangping , Duan Shuhan , Sun Qiuxia , Yan Jiangwei , Liu Chao , Wang Mengge
Published: July 2023

Human Pangenome Reference Consortium (HPRC) and Chinese Pangenome
Consortium (CPC) have pronounced the finish of the pilot work of the
Human Pangenome Project, which aimed to build worldwide
population-representative high-quality haplotype-resolved reference
graph genomes. Graph-based gapless pangenome reference genomes with
enriched genomic diversity and higher completeness and contiguity
possessed the potential for a new beginning for third-generation
sequencing (TGS)-based genomic research and high-performance mapping
rate and variant genotyping for traditional short-read sequencing
platforms. With the new pangenome reference coordinates and
corresponding computation algorithms and methods, forensic integrative
genomics fields will benefit in new-marker identification,
highly-accurate marker genotyping, high-resolution panel development and
corresponding statistical algorithm updates. Here, we discussed the past
advances and new challenges of pangenome-based genomic research and
their integrative genomics applications for variant identification and
new forensic genomic, epigenetic, transcriptomic, and microbiome
practices. We highlighted the necessity and importance of including the
forensic TGS-based platforms, pangenome-based entire landscape of
genomic diversity, pangenome-based study design and graph-based
pangenome reference in short-read NGS mapping and TGS-based innovations
to achieve forensic precision medicine.
Origins of lineage-specific elements via gene duplication, relocation, and regional rearrangement in Neurospora crassa
Authors: Wang Zheng , Wang Yen-Wen , Kasuga Takao , Hassler Hayley , Lopez-Giraldez Francesc , Dong Caihong , Yarden Oded , Townsend Jeffrey
Published: July 2023

The origin of new genes has long been a central interest of evolutionary
biologists. However, their novelty evades reconstruction by the
classical tools of evolutionary modeling. This evasion of insight from
deep ancestral investigation necessitates intensive study of model
species within well-sampled, recently diversified, clades. One such
clade is the model genus Neurospora, members of which lack recent
gene duplications, yet harbor clusters of lineage-specific genes (LSGs)
adjacent to the telomeres. Several Neurospora species are
comprehensively characterized organisms apt for studying the evolution
of LSGs. Using gene synteny, we documented that 78% of
Neurospora LSGs clusters are located in chromosomal regions
featuring extensive tracts of non-coding DNA and duplicated genes. Here
we report several instances of LSGs that are likely from regional
rearrangements and potentially from gene rebirth. To broadly investigate
functions of LSGs, we assembled transcriptomics data from 68
experimental data points and identified co-regulatory modules using
Weighted Gene Correlation Network Analysis, revealing that LSGs are
widely but peripherally involved in known regulatory machinery for
diverse functions. The ancestral status of mas-1 and its
neighbors was investigated in detail, suggesting that it arose from an
ancient lysophospholipase precursor that is ubiquitous in lineages of
the Sordariomycetes; mas-1 plays a role in cell-wall integrity
and cellular sensitivity to antifungal toxins. Our discoveries
illuminate a “rummage region” in the N. crassa genome that
enables formation of new genes and functions to arise via gene
duplication and relocation, followed by fast mutation and recombination
facilitated by tandem repeats and deconstrained non-coding sequences.
A Hybrid Approach Using Survey and ISM Analysis for Security Coding Risks and Best Practices for GSD Enterprises
Authors: Khan Rafiq , Akbar Azeem , Alwageed Hathal Salamah , Alzahrani Abdulrahman , Alzahrani Musaad
Published: July 2023

Global software development (GSD) offers quality results,
cost-effectiveness, and uninterrupted project delivery. However,
integrating security into GSD remains a challenge. This study aims to
enhance security in GSD projects by developing a hybrid approach using
an empirical survey and Interpretive Structural Model (ISM). Initially,
we identified 13 major security-coding risks and 82 practices to
mitigate these by conducting a systematic literature review and
questionnaire survey with 50 GSD security experts. Moreover, 13 experts
were invited to analyze the interrelationships among the practices using
ISM. The ISM analysis revealed that out of the identified
security-coding practices, “never submit security measures to
illegitimate authority”, “avoiding buffer overflow and format string
vulnerabilities”, “control the brute force attack”, and “identify a
middleman attack” were considered fully dependent. While “avoid
revealing information to achieve a secure design” is entirely
independent within the GSD security context. The study aids GSD
professionals in assessing readiness in establishing contractual trust,
understanding the current process pros and cons, and addressing urgent
issues in secure software development processes.
Registry-based observational study of patients with rheumatoid arthritis treated with baricitinib or tofacitinib in a tertiary hospital
Authors: Benítez Elena Guillén , Sabaté Mònica , Ballarín Elena , Espartal Esther , López María , Bosch Montserrat , Boixareu Núria , Diogène Eduard , Danés Immaculada
Published: July 2023

The aim of the study was to describe the use of two Janus kinase
inhibitors (JAKi) in patients with rheumatoid arthritis (RA) recorded at
Vall d’Hebron University Hospital (VHUH) between September 2017-November
2019. The data was extracted from the register of Patients and
Treatments and medical records. Out of the thirty-nine patients included
90.0% were women, median age 56 years (IQR 29-72) and disease duration
15 years (IQR 8-20). Tofacitinib was the most used (28 patients). All
patients had been previously treated with conventional synthetic disease
modifying antirheumatic drugs (csDMARDs), and 79.5% with at least one
biological DMARD (bDMARD). In 16 patients (41.0%) disease activity
category improved. Treatment was withdrawn in 9 patients, mainly due to
lack of efficacy (5). Five patients treated with tofacitinib reported
gastrointestinal and/or skin disorders. This study shows the usefulness
of registries of treated patients to study the use of the new and
expensive drugs.