bluuebunny/crossref_metadata_2025 huggingface dataset:
NARRATIVA VISUAL E HISTÓRIA EM QUADRINHOS: EXPERIÊNCIA DE ESTÁGIO
Authors:   Universidade do Estado de Santa Catarina, Silva Tharciana Goulart da
Published: November 2018

As reflexões deste texto giram em torno de um relato de experiência da disciplina de Estágio Supervisionado III, ministrada pela professora XXXXXXX no segundo semestre de 2013 na Universidade XXXXXXXX. Nesta disciplina atuei como professora de Artes Visuais no Ensino Fundamental, na Escola de Educação Básica Municipal XXXXXXX, localizada na XXXXXXXX. O projeto “Narrativa Visual – História em Quadrinhos” abordou conteúdos que permeiam a História em Quadrinhos como uma narrativa e seus diferentes desdobramentos através de dispositivo artístico, na ação metodológica das aulas o foco pretendido foi possibilitar a reflexão de práticas do ensino da arte como o desenho, pintura e colagem.
Vivências de apreciação, improvisação e composição em sala de aula
Authors: Bichels Roveli , Natera Gislene
Published: November 2018

O presente artigo consiste em um relato das atividades de apreciação, improvisação e composição desenvolvidas no estágio curricular do curso de Licenciatura em Música, com turmas de quarto e quinto anos em uma escola da Rede Municipal de ensino de Florianópolis (SC). As atividades foram elaboradas segundo o estabelecido no planejamento anual do professor supervisor e na matriz curricular da Rede Municipal. Neste contexto, as atividades musicais foram planejadas para proporcionar aos estudantes a vivência com a canção africana, a improvisação e a composição, com o objetivo de fomentar a criatividade, a identidade e o fazer musical coletivo. Conclui-se que é importante que o professor liberte-se das amarras de um ensino musical dito tradicional e que os estudantes precisam passar por múltiplas vivências para que consigam analisar, repensar e redefinir conceitos relacionados ao fazer artístico, além de desenvolver sua percepção e capacidade de apreciação musical.
Caminhos de um programa de iniciação à docência em Artes Cênicas no Mato Grosso do Sul
Authors:   Universidade do Estado de Santa Catarina/UDESC, Fernandes Matheus Vinícius de Souza
Published: November 2018

Neste trabalho relato algumas das minhas experiências advindas do subprojeto “Formação Humanística” do Programa Institucio- nal de Bolsas de Iniciação a Docência (PIBID/UFGD) do curso de Licenciatura em Artes Cênicas, no período de 2011 a 2013, relacionando-a com minha vida discente na rede pública e parti- cular no estado do Mato Grosso do Sul. O subprojeto das Artes Cênicas, financiado pela CAPES, tem por objetivo fomentar uma prática docente na área teatral como incentivo à formação do curso de licenciatura acima citado. O projeto não somente cumpriu sua função em minha formação como artista-docente e de muitos ou- tros artistas-educadores participantes, como promoveu a prática e fruição teatral, vertente da arte que, até então, era distanciada de muitos educandos das escolas parceiras do programa.
Reflexões sobre Arte Educação: encontro com a docência e percepções sobre a estrutura escolar
Authors:   Artes Visuais Licenciatura - DAV/CEART/UDESC, Spada Ana Carolina Castello Branco
Published: November 2018

Este trabalho expõe reflexões que percorrem desde as observações até a prática docente realizada em uma escola da rede pública de ensino em Florianópolis. Os dados apresentados e a consolidação do projeto resultam de pesquisa e experiência pedagógica em Artes Visuais pela participação no Programa Institucional de Bolsa de Iniciação à Docência – PIBID (CAPES) – Artes Visuais, inicia- do em 2012, sob a coordenação da Profa. Dra. Jociele Lampert, da Universidade do Estado de Santa Catarina. É de extrema relevân- cia investigar a estrutura em que se desenvolve o ensino de Artes Visuais e as formas de combater o ensino conservador que, há mui- to tempo, não produz resultados eficazes, tampouco propicia uma transformação social a partir do sujeito crítico e criativo.
Os grupos de artistas plásticos de Florianópolis nos anos 1980
Authors:   Universidade do Estado de Santa Catarina, Makowiecky Sandra , Henicka Marli Salete
Published: November 2018

Este artigo apresenta a história e os propósitos de três grupos de artistas que movimentaram a cena cultural de Florianópolis na década de 1980. O Grupo Nha-ú, criado em 1980, liderado pelo ceramista e professor Luiz Carlos Canabarro; o Grupo Artmosfera, surgido em 1983; o Grupo Guará, criado em 1986. Formados por estudantes do Centro de Artes da Universidade do Estado de Santa Catarina, esses grupos atuaram em Florianópolis em exposições, performances e ações coletivas – também em outros estados, como a performance “não autorizada” em1987 na Bienal Internacional de São Paulo. Quais eram as propostas artísticas desses grupos? O que os uniu? Quais foram os principais acontecimentos das artes visuais no Estado e no País nessa época e quais influências tiveram sobre esses grupos? O objetivo deste artigo é aproximar o olhar do pesquisador da produção artística local, registrando a história recente das artes visuais em Santa Catarina.
Do Desenho ao Design: a experiência do professor Célio no centro de artes
Authors:   Universidade do Estado de Santa Catarina, Madeira Ana Ester Correia
Published: November 2018

O professor Célio Teodorico dos Santos, Mestre em Engenharia de Produção (UFSC) e Doutor em Engenharia Mecânica (UFSC), é um dos docentes mais antigos do Centro de Artes (CEART), pois atua neste espaço há 19 anos, sendo que o centro existe há 30 anos. Sua atuação iniciou na montagem do primeiro Laboratório Brasileiro de Design (LBDI) em 1984, projeto do qual participou ativamente até 1996, quando ingressou no corpo docente da UDESC, como professor do primeiro Curso de Design de Santa Catarina. Sua trajetória foi marcada por atuações na sala de aula ministrando diversas disciplinas na área, pesquisando sobre o seu objeto de estudo e atuando na administração do departamento de Design. Este relato é parte do projeto “Dossiê: CEART 30 anos” que tem como tema a história da docência neste espaço. Através da metodologia da história oral, pretende-se dar vida à experiência deste profissional, destacando fatos e reflexões relatados por ele dentro do Centro de Artes
Fragmentos de uma poética que não cala: Osmar Pisani
Authors: Makowiecky Sandra , Oliveira Sandra Regina Ramalho
Published: November 2018

Homenagem.
Desenvolvimento de habilidades musicais em crianças autistas
Authors:   Universidade Federal do Estado do Rio de Janeiro - UNIRIO, Santos Claudia Eboli
Published: December 2018

Este trabalho apresenta o projeto de extensão “Desenvolvimento de Habilidades Musicais em Crianças Autistas”, parte da pesquisa de Doutorado em desenvolvimento no Programa de Pós-Graduação em Música (PPGM) da Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Participam do projeto 20 crianças com transtornos do espectro do autismo (TEA) na faixa de 6 a 14 anos, três estagiários das áreas de musicoterapia, psicologia e educação musical além da pesquisadora. Os atendimentos são gratuitos e acontecem uma vez por semana. Com o projeto pretende-se identificar as habilidades musicais desses indivíduos, tomando esta identificação como ação fundamental para a elaboração de estratégias que contribuirão com o seu desenvolvimento musical global. Para a identificação das habilidades musicais dos sujeitos da pesquisa, e posterior avaliação do desenvolvimento dessas habilidades, foi criado um instrumento cujos critérios dizem respeito ao comportamento musical dos indivíduos. Além dos objetivos direcionados ao desenvolvimento musical dos sujeitos, o projeto se propõe, também, a alcançar objetivos relativos à melhora da interação social e da comunicação dos mesmos.
Cuando la identidad está en riesgo: Musicoterapia, Cultura y Migración en el Hospital Público Pediátrico
Authors:   UBA, Biegun Karin , Alperovich Natalia ,   UBA
Published: December 2018

Dentro de la Escuela Hospitalaria, institución que funciona en el contexto del Hospital Público Pediátrico de Buenos Aires, encontramos numerosos pacientes internados que proceden de otras provincias o países limítrofes. El desconocimiento de la cultura del “otro” por parte de médicos, enfermeros y docentes, redunda frecuentemente en una situación de marginación y aculturación para el paciente. A través de la música, se trabajará en el proceso de reconstrucción dinámica de la identidad del niño, que se ve amenazada por la doble situación de desarraigo inherente a la migración y a la hospitalización.
Mapeamento dos Taquareiros nos assentamentos e arredores do município de Lebon Régis - SC
Authors:   Universidade do Estado de Santa Catarina (UDESC), Prado Eliane do , Kinceler José Luiz  (in memoriam) , Franzoni Tereza Mara ,   Universidade do Estado de Santa Catarina (UDESC)
Published: December 2018

Este trabalho apresenta parte de uma pesquisa realizada como requisito do Curso de Especialização em Arte no Campo oferecido pela UDESC- Universidade do Estado de Santa Catarina numa parceria com o Movimento dos Trabalhadores Rurais Sem Terra (MST) e com o apoio do Instituto Nacional de Colonização e Reforma Agrária. O mesmo é relacionado aos taquareiros, artesãos que fazem artesanato de taquara, uma espécie de bambu mais fino e maleável. De suas fibras é possível tecer balaios, peneiras, cestos entre outros. Essas pessoas, artesãs, que ainda existem nos assentamentos e arredores do município de Lebon Régis, Timbó Grande e Santa Cecília, chamam a atenção e simultaneamente, causam preocupação por estarem deixando de fazer sua Arte. Neste sentido, aprouve registrar seus saberes no intuito de valorizar e divulgar o trabalho/arte por eles desenvolvido.
Corpos grandes e pequenos na dança do inesperado: Considerações sobre a prática da dança entre adultos e bebês.
Authors:   UDESC, Gois Amanda
Published: December 2018

Este artigo propõe uma leitura sobre a dança entre adultos e bebês. A partir da filosofia especulativa e através de referencias de um ensaio entitulado O Ovo, de Clarice Lispector, sugere-se uma pedagogia para o movimento que situa a dança como arte relacional. A partir da observação das sessões de Dança para Corpos Grandes e Pequenos, entremeia-se essas práticas com os pensamentos de Félix Guatarri, Hanna Arendt e do movimento da dança pós-moderna, para questionar o corpo em experiências pedagógicas e práticas do movimento.
Território e poder em Michel Foucault: propondo um dialogo com a Geografia/Territory and power in Michel Foucault: Proposed a dialogue with geography
Authors: Fuini Lucas Labigalini
Published: December 2018

Este artigo pretende estabelecer um diálogo com a obra de Michel Foucault no sentido de se buscar esclarecer o sentido dado pelo autor ao conceito de Território - relacionado diretamente à construção de relações de poder- compreendendo algumas das influências de seus escritos na produção geográfica, em especial a brasileira. Pautado na arqueologia do saber e na genealogia do poder, o autor analisa a construções históricas das estruturas de poder e de controle/vigilância nas sociedades modernas, dando especial destaque à dimensão espacial dos processos sociais, deixando um legado importante, que perpassa a obra de geógrafos brasileiros e estrangeiros.Palavras-chave: Foucault; Geografia; poder; território. ABSTRACTThis article intends to establish a dialogue with the work of Michel Foucault in order to clarify the meaning given by the author to the concept of Territory - directly related to the construction of relations of power - including some of the influences of his writings on the geographical production, in particular the Brazilian. Based on the archeology of knowledge and the genealogy of power, the author analyzes the historical constructions of power and control / surveillance structures in modern societies, with a special emphasis on the spatial dimension of social processes, leaving an important legacy that permeates the work Brazilian and foreigners geographers.Keywords: Foucault; Geography; power; territory.
Feminisme neoliberal: un oxímoron?
Authors: Medina-Vicent Maria
Published: November 2018

Neoliberal Feminism: An Oxymoron?
 
 
Resum: En el present escrit tractem d’aproximar-nos al concepte de “feminisme neoliberal” per tal d’identificar-ne les principals característiques i contradiccions. Així doncs, l’objectiu principal que ens plantegem tracta de discernir si és possible, atenent al context actual de desenvolupament del moviment feminista en un marc neoliberal, parlar de “feminisme neoliberal”, o si pel contrari, es tracta d’un concepte que és en sí mateix un oxímoron. Partint del sentit de transformació social cap a la justícia intrínsec al moviment feminista, tractarem de veure com la lògica neoliberal ha condicionat o influenciat en aquest moviment en l’actualitat. Alhora establirem una hipòtesis que es formula com segueix: l’existència d’una identitat feminista neoliberal conviu amb un ressorgiment de l’arrel política del feminisme, cosa que converteix l’escenari actual en un context ple de reptes i dilemes per a aquest moviment. Concloem que en aquests temps el compromís crític del feminisme s’ha de mostrar més fort que mai front a les immanències del sistema neoliberal.

Paraules clau: feminisme neoliberal, postfeminisme, neoliberalisme, governabilitat.

Abstract: In this paper we approach the concept “Neoliberal Feminism” in order to identify their main characteristics and contradictions. The main objective of this paper is to discern whether it is possible to talk about “Neoliberal Feminism” in response to the development of feminism in a neoliberal framework, or on the contrary, whether this concept is just an oxymoron. Departing from the sense of social transformation towards justice intrinsic to the feminist movement, we address how the neoliberal logic has conditioned or influenced this movement at present. At the same time, we establish a hypothesis that is formulated as follows: the existence of a neoliberal feminist identity coexists with a resurgence of the political roots of feminism. This reality turns the current scenario into a context full of challenges and dilemmas for the feminist struggle. We conclude that nowadays the critical commitment of feminism must be stronger than ever in front of the immanence of the neoliberal system.
 
Keywords: Neoliberal Feminism, Postfeminism, Neoliberalism, Governability.
Quaderns de filosofia V, 2
Authors: Fia Quad
Published: November 2018

Número complet / Número completo / Full Issue
Descartes y los frutos de la mecánica: la conquista de la buena vida terrenal
Authors: García Rodríguez Sergio
Published: November 2018

Descartes and the fruits of mechanics: the conquest of the earthly good life
 
 
Resumen: El proyecto de Descartes profesa un notable interés encaminado al dominio de la naturaleza que, en última instancia, debe conducir al sujeto a vivir la mejor vida posible. A este propósito se dirigen los distintos frutos, resultado de la ciencia cartesiana: Medicina, Moral y Mecánica. El presente artículo analiza los frutos de la mecánica a fin de determinar su papel respecto a la consecución de una buena vida. Para ello se analizará el tipo de bien de que nos provee la mecánica, así como los distintos instrumentos que permiten su consecución.
 
Palabras clave: artefactos, artesanos, bienes terrenales, buena vida, comodidad, Descartes, frutos de la mecánica.
 
 
Abstract: The Cartesian project professes a remarkable interest in the mastery of nature which, ultimately, leads the subject to live the best possible life. The various fruits of the philosophical tree which result from the Cartesian science —Medicine, Moral and Mechanics— are directed to this purpose. This paper analyzes the fruits of mechanics in order to determine its role in the achievement of a good life. For this purpose, it will be analyzed the kind of good which mechanics provides us and the various instruments necessary to achieve it.
 
Keywords: artifacts, craftsman, Descartes, comfort, earthly goods, fruits of mechanics, good life.
Entre la sintaxis y el discurso: el caso de 'a lo mejor' y 'al menos' en la conversación coloquial
Authors: Pardo-Llibrer Adrià
Published: December 2018

This paper studies the Spanish forms a lo mejor (maybe) and al menos (at least) from a modular perspective, revisiting the categorization of a lo major and al menos according to the involved linguistic level and analyzing the relations between the adverbial uses of these forms and the discursive ones. Such relations show that the forms a lo mejor and al menos can be considered bicategorial lexical items, what is implemented by a corpus study based on data from spoken language.
Reseña de Muñoz-Basols, Moreno, Taboada & Lacorte, 'Introducción a la lingüística hispánica actual: teoría y práctica'
Authors: Fábregas Antonio
Published: December 2018

Esta reseña discute la contribución del volumen con respecto a tres parámetros centrales dentro de la integración entre lingüística y práctica docente: la reflexión lingüística, la variación y la forma de presentar los contenidos de lingüística teórica.
A single Spanish version of maternal and paternal postnatal attachment scales: validation and conceptual analysis
Authors: Riera-Martín Anna , Oliver-Roig Antonio , Martínez-Pampliega Ana , Cormenzana-Redondo Susana , Clement-Carbonell Violeta , Richart-Martínez Miguel
Published: November 2018

Background

Postnatal bonding constitutes a major process during the postpartum period, and there is evidence that bonding difficulties have negative consequences for parents’ mental health and the child’s development. However, the conceptualization of postnatal bonding presents inconsistencies, as well as problems in having instruments that encompasses the father figure. The objective was to adapt the maternal postnatal attachment scale (MPAS) and the paternal postnatal attachment scale (PPAS) to Spanish, to evaluate its validity and reliability and to analyze the construct dimensionality of both questionnaires from a gender perspective.

Methods

Instrumental design. In 2016–2017, a sample of 571 mothers and 376 fathers, with children between 6 and 11 months of age, responded to the Spanish version of MPAS and PPAS, respectively. After a process of translation-back-translation of the instrument, we empirically analyzed the internal consistency (Cronbach alpha, composite reliability (CR)) construct and concurrent validity (with regard to postpartum depression and dyadic adjustment). Additionally, we studied the instrument’s content validity, using the Delphi methodology; and the differential analysis in both samples (mothers and fathers), examining the invariance.

Results

A short version of 15 items was obtained, common for mothers and fathers. The results of the Delphi methodology showed a 100% inter-judge agreement, highlighting the absence of differences in the adequacy of the items as a function of the parents’ gender. Confirmatory factor analysis showed a good fit of three original factors proposed by the authors. The global Cronbach alpha coefficients in the total sample were adequate (mothers, 0.70; fathers, 0.78); and Cronbach alpha of each dimension in the case of mothers was 0.50 (Quality of bonding), 0.55 (Absence of hostility), and 0.60 (Pleasure in interaction); in the case of fathers, it was respectively 0.54, 0.64, and 0.72. CR of each dimension were: quality of bonding, 0.74 in mothers and 0.80 in fathers; absence of hostility, 0.93 in mothers and 0.94 in fathers; pleasure in interaction, 0.83 in mothers and 0.90 in fathers. With regard to the analysis of group invariance, the results revealed empirical evidence of configural and metric invariance. Concurrent validity showed moderate negative correlations for postnatal depression (mothers, r = −0.41, p < 0.001; fathers, r = −0.38, p < 0.001), and positive correlations for dyadic adjustment (mothers, r = 0.39, p < 0.001; fathers, r = 0.44, p < 0.001).

Discussion

A new version of the instrument was generated, with good psychometric properties, adequate for use both with mothers and with fathers. This scale helps evaluate postnatal maternal and paternal bonding, allowing to study it from within the family system, a necessary step forward to advance perinatal mental health.
When and where to hatch? Red-eyed treefrog embryos use light cues in two contexts
Authors: Güell Brandon A. , Warkentin Karen M.
Published: December 2018

Hatching timing is under strong selection and environmentally cued in many species. Embryos use multiple sensory modalities to inform hatching timing and many have spontaneous hatching patterns adaptively synchronized to natural cycles. Embryos can also adaptively shift their hatching timing in response to environmental cues indicating immediate threats or opportunities. Such cued shifts in hatching are widespread among amphibians; however, we know little about what, if anything, regulates their spontaneous hatching. Moreover, in addition to selection on hatching timing, embryos may experience benefits or suffer costs due to the spatial orientation of hatching. Amphibian eggs generally lack internal constraints on hatching direction but embryos might, nonetheless, use external cues to inform hatching orientation. The terrestrial embryos of red-eyed treefrogs, Agalychnis callidryas, hatch rapidly and prematurely in response to vibrational cues in egg-predator attacks and hypoxia if flooded. Here we examined A. callidryas’ use of light cues in hatching timing and orientation. To assess patterns of spontaneous hatching and the role of light cues in their diel timing, we recorded hatching times for siblings distributed across three light environments: continuous light, continuous dark, and a 12L:12D photoperiod. Under a natural photoperiod, embryos showed a clear diel pattern of synchronous hatching shortly after nightfall. Hatching was desynchronized in both continuous light and continuous darkness. It was also delayed by continuous light, but not accelerated by continuous dark, suggesting the onset of dark serves as a hatching cue. We examined hatching orientation and light as a potential directional cue for flooded embryos. Embryos flooded in their clutches almost always hatched toward open water, whereas individual eggs flooded in glass cups often failed to do so, suggesting the natural context provides a directional cue. To test if flooded embryos orient hatching toward light, we placed individual eggs in tubes with one end illuminated and the other dark, then flooded them and recorded hatching direction. Most embryos hatched toward the light, suggesting they use light as a directional cue. Our results support that A. callidryas embryos use light cues to inform both when and where to hatch. Both the spatial orientation of hatching and the timing of spontaneous hatching may affect fitness and be informed by cues in a broader range of species than is currently appreciated.
The proportion of core species in a community varies with spatial scale and environmental heterogeneity
Authors: Jenkins Molly F. , White Ethan P. , Hurlbert Allen H.
Published: November 2018

Ecological communities are composed of a combination of core species that maintain local viable populations and transient species that occur infrequently due to dispersal from surrounding regions. Preliminary work indicates that while core and transient species are both commonly observed in community surveys of a wide range of taxonomic groups, their relative prevalence varies substantially from one community to another depending upon the spatial scale at which the community was characterized and its environmental context. We used a geographically extensive dataset of 968 bird community time series to quantitatively describe how the proportion of core species in a community varies with spatial scale and environmental heterogeneity. We found that the proportion of core species in an assemblage increased with spatial scale in a positive decelerating fashion with a concomitant decrease in the proportion of transient species. Variation in the shape of this scaling relationship between sites was related to regional environmental heterogeneity, with lower proportions of core species at a given scale associated with high environmental heterogeneity. Understanding this influence of scale and environmental heterogeneity on the proportion of core species may help resolve discrepancies between studies of biotic interactions, resource availability, and mass effects conducted at different scales, because the importance of these and other ecological processes are expected to differ substantially between core and transient species.
¿Turismo juvenil? Los viajes en las biografías de jóvenes de barrios populares de Buenos Aires
Authors: Tapia Silvia Alejandra
Published: December 2018

En este artículo presento resultados de mi tesis doctoral cuyo objetivo general es analizar las experiencias de jóvenes de barrios populares de Buenos Aires, indagando articulaciones entre movilidades y corporalidades en sus procesos de individuación. Se propuso un abordaje cualitativo, siguiendo los lineamientos de la teoría fundamentada. Se realizaron entrevistas semi-estructuradas, relatos biográficos y observación participante en una organización social que ofrece talleres circenses gratuitos a jóvenes de barrios populares. Investigaciones comienzan a advertir el turismo juvenil, destacando el aumento de jóvenes viajeros y los núcleos turísticos creados en torno a éstos. Ahora bien, las posibilidades de viajar y vacacionar difiere entre distintos grupos sociales, por lo que su abordaje se vuelve una forma de reconocer desigualdades. En este trabajo se identifican las características de los viajes presentes en las biografías de jóvenes entrevistados, el modo en que son percibidos, los sentidos en torno éstos, así como los facilitadores y las limitaciones para llevarlos a cabo. De los emergentes en sus relatos se distinguen tres tipos de viajes: posibilitados y motivados por vínculos familiares, propuestos por agrupaciones religiosas asentadas en barrios populares de la ciudad para supervivencia en la naturaleza y proyectados a futuro, como deseo de movilidad potencial.
СИНТЕЗ И РЕАКЦИОННАЯ СПОСОБНОСТЬ ПРОДУКТА АННЕЛИРОВАНИЯ МЕТИЛТИАЗОЛЬНОГО ФРАГМЕНТА К 2-(ФУРАН-2-ИЛ)БЕНЗИМИДАЗОЛУ, "Журнал органической химии"
Authors: Ельчанинов М. М. , Александров А.А.
Published: November 2018

По реакции 1,2-диамино-4-нитробензола с фуран-2-карбальдегидом в присутствии сульфата меди синтезирован 2-(фуран-2-ил)-5(6)-нитро-1Н-бензимидазол. При его N-метилировании образуются 1- метил-5(6)-нитроизомеры. При восстановлении изомеров оловом в конц. HCl выделен чистый
НИТРОВАНИЕ 3-МЕТИЛАЦЕПЕРИДАЗИНОВ БОЛЬШИМ ИЗБЫТКОМ ДЫМЯЩЕЙ АЗОТНОЙ КИСЛОТЫ, "Журнал органической химии"
Authors: Омеличкин Н.И. , Миняева Л.Г. , Милов А.А. , Кузьмина Л.Г. , Межерицкий В.В.
Published: November 2018

Нитрование N-ацетил-З-метилацеперидазина 2-3-кратным избытком азотной кислоты (d 1.36, 1.48) в ледяной уксусной кислоте приводит к образованию исключительно моно- и динитропроизводных. Нитрование 3-метилацеперидазина и его N-алкил- и N-ацетилзамещённых производных 6-9-кратным избытком дымящей азотной кислоты (d 1.54) в тех же условиях приводит к образованию не только ожидаемых продуктов моно- и динитрования, но и к продукту электрофильного присоединения азотной кислоты по двойной связи аценафтенового остова молекулы (продукту тринитрования).
НОВЫЕ РЕАКЦИИ (2-АМИНОФЕНИЛ)ДИФЕНИЛМЕТАНОЛА С КАРБОНИЛЬНЫМИ СОЕДИНЕНИЯМИ, "Журнал органической химии"
Authors: Громачевская Е.В. , Пушкарева К.С. , Беспалов А.В. , Стрелков В.Д.
Published: November 2018

Взаимодействие (2-аминофенил)дифенилметанола с кетонами (димедоном, камфорой и 3-бром- камфорой) в уксусной кислоте приводит к образованию арилиминов камфоры и 3-бромкамфоры, замещенному тетрагидроакридин-1(2Н)-ону и 2-метил-4,4-дифенилбензоксазину.
О МЕТОДЕ ЗЕРКАЛЬНЫХ ТОЧЕК, "Фундаментальная и прикладная гидрофизика"
Authors: Гардашов Р. Г.
Published: November 2018

Для расчёта характеристик света, отражённого от взволнованной морской поверхности, применяются два подхода. Первый есть так называемый «Метод стохастических распределённых площадок», который позволяет рассчитывать только средние характеристики отражённого света. Второй - так называемый «Метод зеркальных точек», который для средних характеристик даёт тот же самый результат, что и метод стохастических распределённых площадок, однако метод зеркальных точек может быть применён для расчёта флуктуаций характеристик отражённого света. Кроме того, метод зеркальных точек имеет дело такими визуально воспринимаемыми геометрическими параметрами морской поверхности, какими являются расположение и число зеркальных точек, кривизны в зеркальных точках, которые пропорциональны размерам бликов. Эти параметры могут быть определены из снимки бликов и могут служить для определения состояния волнения посредством решения прямой и обратной задачи, которая сформулирована в виде интегрального уравнения Фредгольма 1-го рода. Из этих параметров может быть определён также мгновенный рельеф морской поверхности, что открывает путь к постановке и решению новых задач. Корректность полученных теоретических выражений проверяется численным моделированием.
Long noncoding RNAs as regulators of cancer immunity
Authors: Denaro Nerina , Merlano Marco Carlo , Lo Nigro Cristiana
Published: November 2018

Long noncoding RNAs (lncRNAs) are increasingly known to be important in cancer as they directly interact with the cell cycle, proliferation pathways and microbiome balance. Moreover, lncRNAs regulate the immune system: they do not directly encode proteins of innate or adaptive immunity, but regulate immune cell differentiation and function, such as dendritic cell activity, T cell ratio and metabolism. The result of this complex interaction is that lncRNAs regulate cancer processes through a complex multimodal system involving immunity, metabolism and infection. The possible functions of lncRNAs and their roles in the regulation of cancer immunity will be reported and discussed in the present review. Recent studies showed their function as regulators in the tumour microenvironment (TME), epithelial–mesenchymal transition, microbiota, metabolism and immune cell differentiation. However, there is not much knowledge regarding their roles in cancer immunity regulation. Thus, the main aim of this review is to describe lncRNAs that have specifically been associated with immunity, the immune cycle and the TME.
New biomarkers of Kawasaki disease identified by urine proteomic analysis
Authors: Hu Hui‐Min , Du Hong‐Wu , Cui Jia‐Wen , Feng De‐Qin , Du Zhong‐Dong
Published: November 2018

Kawasaki disease (KD) is an acute systemic vasculitis that mainly afflicts infants and young children. The symptoms of KD are similar to those of various febrile diseases. Here, we attempted to develop accurate diagnostic biomarkers of KD by performing urine proteomic analysis of samples from healthy controls, patients with KD, and patients with another febrile disease, pneumonia (two patients). We identified differentially expressed proteins (DEPs) in KD as compared to normal controls. We also constructed functional annotation and protein–protein interaction (PPI) networks of DEPs in KD and pneumonia. DEPs common to both KD and pneumonia were identified, as well as DEPs specific to KD. Compared to normal control, 43 and 62 DEPs were identified in KD and pneumonia, respectively. Serine hydroxymethyltransferase 1 is a hub protein of the KD‐specific PPI network. Thirteen DEPs common to both KD and pneumonia and 30 DEPs specific to KD were identified. Of these, the expression of eight DEPs could cluster normal and pneumonia samples into one group and cluster KD samples into another group based on hierarchical clustering. Our study identified several DEPs that may play a role in KD and that may serve as diagnostic biomarkers to distinguish patients with KD from both normal control and other febrile diseases.
Significant Enhancement in Cryogenic Mechanical Properties of Cu–Al Alloy via Minor Recrystallization
Authors: Lin H. R. , Tian Y. Z. , Sun S. J. , Yang H. J. , Zhang Z. F.
Published: November 2018

The mechanical properties of cold‐rolled (CR) and partially recrystallized (PRX) Cu–Al alloy are investigated by tensile tests at 77 and 293 K. While the uniform elongation is limited for the CR specimens at both temperatures, uniform elongation is enhanced unprecedentedly from 2.4% at 293 K to 16.5% at 77 K for the PRX specimens. In contrast to the sole contribution of recrystallized grains via wavy slip at 293 K, the prominent uniform elongation at 77 K is attributed to the multiple deformation mechanisms within recrystallized grains and the harmonization of plastic deformation between recrystallized grains and matrix.
Manipulating Polysulfide Conversion with Strongly Coupled Fe3O4 and Nitrogen Doped Carbon for Stable and High Capacity Lithium–Sulfur Batteries
Authors: Lu Ke , Zhang Hong , Gao Siyuan , Ma Houyi , Chen Junzheng , Cheng Yingwen
Published: November 2018

Li–S batteries are among the most promising energy storage technologies but their commercialization faces substantial challenges, largely due to difficulties in controlling their reaction pathways under practical conditions. Here, the synthesis of strongly coupled Fe3O4 and N‐doped carbon directly in flexible carbon cloth is demonstrated, as well as their novel use for hosting sulfur with outstanding performance for Li–S batteries. It is discovered that the synergistic effects of Fe3O4 and N‐carbon bring strong adsorption toward lithium polysulfide, and ensure nearly complete conversion of short‐chain polysulfide to Li2S during discharge. The Li2S solids generated on these novel hosts are extremely reactive and can be readily charged back to S without a noticeable overpotential. The critical roles of Fe3O4 and N‐doped carbon are studied and direct correlations are established between their surface concentration/crystallinity and the Li2S4 to Li2S conversion capacity. This novel manipulation of polysulfide conversion allows to fabricate freestanding and flexible sulfur cathodes that deliver a specific capacity of 1316 mAh g−1 at 0.1C and stable cycling for 1000 cycles at 0.2C under a high sulfur loading of ≈4.7 mg cm−2.
C1‐symmetric β‐Diketiminatoiron(II) Complexes for Hydroamination of Primary Alkenylamines
Authors: Lepori Clément , Guillot Régis , Hannedouche Jérôme
Published: November 2018

The synthesis and solid‐state characterization of an array of well‐defined low‐coordinate C1‐symmetric β‐diketiminatoiron(II) alkyl complexes B3–B6 featuring steric and electronic variations on one of the N‐aryl substituents of the β‐diketiminate ligand scaffold are reported. All complexes display unique catalytic abilities of promoting the selective exo‐cyclohydroamination of unprotected 2,2‐diphenylpent‐4‐en‐1‐amine (1 a) under mild reactions conditions. The incorporation of a potentially coordinative ortho‐methoxy substituent on one of the N‐aryl rings of the β‐diketiminate skeleton, in conjunction with a more crowded 2,6‐diisopropylphenyl group on the other, affords a far more active catalyst (B3) than our previously reported C2‐symmetric β‐diketiminatoiron(II) alkyl complex B (Ar1=Ar2=2,4,6‐(Me)3C6H2)/cyclopentylamine system. Comparative studies let us postulate that this superior activity of B3, when compared with B4‐B6, is likely arising from steric effects and/or the coordinating ability of the ortho‐methoxy substituent. The scope and limitations of this novel C1‐symmetric β‐diketiminatoiron(II) alkyl complex B3 are also presented.

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Chitosan/graphene oxide‐based multifunctional pH‐responsive hydrogel with significant mechanical strength, self‐healing property, and shape memory effect
Authors: Nath Jayashree , Chowdhury Anupam , Dolui Swapan Kumar
Published: November 2018

Synthesis of hydrogel with multifunctional properties still remains a challenge within the scientific community. Hydrogels having stimulus‐responsive properties are a few of the desired properties for real‐life applications. This work highlights the synthesis of multifunctional pH‐sensitive hydrogels, based on chitosan (CS) and graphene oxide (GO), via physical cross‐linking. The properties of hydrogels were optimized using various characterization techniques. Successful GO incorporation into the CS matrix was clearly confirmed by Fourier transform infrared analysis. Scanning electron microscope and TEM micrographs portray rough and porous surface morphology of the composite hydrogels. The prepared hydrogels have demonstrated enhanced thermal properties due to the incorporation of GO. To investigate the pH‐responsive behavior, the pH‐dependent study for the hydrogels was carried out in acidic and basic media. Increasing the amount of GO content inside the gel imparted enhanced mechanical properties to the hydrogel. There was a sharp increase in tensile strength from 4.37 to 20.96 MPa accompanied by an increase in Young's modulus from 0.122 to 0.364 MPa. DMA confirmed better elastic behavior of the composite hydrogel. The hydrogel exhibited fast self‐healing property when cleaved under ambient conditions. In addition, the hydrogel also exhibited a shape memory effect both in the alcoholic solution and in the solution of metal cation.
Effect of an opioid management program for Colorado workers’ compensation providers on adherence to treatment guidelines for chronic pain
Authors: Tenney Liliana , McKenzie Lisa M. , Matus Brenden , Mueller Kathryn , Newman Lee S.
Published: November 2018

Objective

The aim of this study was to examine adherence of state guidelines for Colorado workers’ compensation physicians/providers treating individuals as injured workers with chronic pain after initiation of an opioid management program and provider incentives.

Methods

A retrospective cohort of chronic, non‐cancer pain claims was constructed from the Colorado's workers’ compensation database. Adherence to treatment guidelines and opioid prescribing practices were evaluated during implementation of a new billing code to incentivize adherence.

Results

Overall, less than 33% of claims showed evidence of opioid management. Comprehensive opioid management was observed in only 4.4% of claims. In 2010, after implementing the new billing code, the ratio of long acting opioids to short acting opioids decreased from 0.2 to 0.13; returning to 0.2 in one year. Similarly, morphine equivalent doses declined for a short period.

Conclusions

Incentivizing physicians to adhere to chronic pain management guidelines only temporarily improves prescribing practices.
Optische Chiralitätssensorik mit ligandenfreien, weit verbreiteten Cobaltsalzen
Authors: De los Santos Zeus A. , Lynch Ciarán C. , Wolf Christian
Published: November 2018

Die Einführung breit anwendbarer chiroptischer Enantiomerenanalytik ist eine anspruchsvolle Aufgabe und erfordert in der Regel sorgfältig entwickelte molekulare Rezeptoren oder supramolekulare Verbindungen. Hier beschreiben wir die enantioselektive Sondierung von 35 Aminosäuren, Phosphonsäuren, Hydroxysäuren, Aminoalkoholen und Diaminen mit ligandenfreien Cobaltsalzen. Die chiroptische Analyse der Enantiomerenzusammensetzung und Konzentration kleinster Probemengen erfolgt mit hoher Genauigkeit mittels weit verbreiteter Cobaltsalze und Wasserstoffperoxid als Oxidationsmittel. Trotz des Fehlens eines zusätzlichen Liganden kann diese auf einfachen Cobaltsalzen basierende Analyse auf aromatische und aliphatische Verbindungen angewendet werden und ergibt intensive CD‐Signale bei hohen Wellenlängen. Diese Methode beseitigt die allgemeine Notwendigkeit von chromophoren Liganden oder der Analyt‐Liganden‐Chiralitätsinduktion, um chiroptische Signale durch Exciton‐gekoppelten Circulardichroismus zu erzeugen, und sie besticht durch operative Einfachheit, Kosteneffizienz, Abfallreduzierung und Geschwindigkeit.
Erforschung der fundamentalen Strukturen des Lebens: Nicht zielgerichtete chemische Analyse von Einzelzellen und subzellulären Strukturen
Authors: Neumann Elizabeth K. , Do Thanh D. , Comi Troy J. , Sweedler Jonathan V.
Published: November 2018

Zellen sind die grundlegende Funktions‐ und Struktureinheit lebender Organismen. Einzellige Gemeinschaften wie auch mehrzellige Spezies produzieren eine erstaunliche chemische Diversität, die eine große Bandbreite an unterschiedlichen Funktionen ermöglicht, dennoch hat jede Zelle zahlreiche Merkmale, die allen lebenden Organismen gemeinsam sind. Während es viele Ansätze zur Erforschung dieser chemischen Diversität gibt, sind nur wenige nicht zielgerichtet und in der Lage, die Analyse von Hunderten von verschiedenen Substanzen mit zellulärer Auflösung zu bewerkstelligen. In diesem Aufsatz diskutieren wir solche nicht zielgerichteten Ansätze, die verwendet werden, um umfassende chemische Analysen durchzuführen, Informationen für die chemische Bildgebung bereitzustellen oder Hochdurchsatz‐Profilingdaten über einzelne Zellen zu erhalten. Die Fähigkeiten der Einzelzellmessung entwickeln sich rasant bezüglich Durchsatz, Nachweisgrenzen und der Vollständigkeit der chemischen Analysen; diese Verbesserungen ermöglichen es, immer komplexere physiologische Phänomene, wie z. B. Lernen, Gedächtnis und Verhalten zu verstehen.
Catalyst‐Sidearm‐Induced Stereoselectivity Switching in Polymerization of a Racemic Lactone for Stereocomplexed Crystalline Polymer with a Circular Life Cycle
Authors: Zhu Jian‐Bo , Chen Eugene Y.‐X.
Published: November 2018

Construction of robust, stereocomplexed (sc) crystalline material, based on a recently discovered infinitely recyclable polymer system, requires blending of enantiomeric polymer chains produced from respective enantiopure, fused six‐five bicyclic lactones. Herein, the stereoselective polymerization of the racemic monomer by yttrium catalysts bearing tetradentate ligands is reported, where the tethered donor sidearm switches the heteroselectivity of the catalyst to isoselectivity when it is changed from the β‐OMe to β‐NMe2 sidearm. The latter catalyst produces an isotactic stereoblock polymer (Pm up to 0.95) that forms the crystalline sc‐material with a Tm of up to 171 °C. This sc‐material can be fully depolymerized back to rac‐monomer in a quantitative yield and purity, thus establishing its circular life cycle.
(Dynamic) Kinetic Resolution of Enamines/Imines: Enantioselective N‐Heterocyclic Carbene Catalyzed [3+3] Annulation of Bromoenals and Enamines/Imines
Authors: Chen Kun‐Quan , Gao Zhong‐Hua , Ye Song
Published: November 2018

The enantioselective N‐heterocyclic carbene catalyzed [3+3] annulation of α‐bromoenals by dynamic kinetic resolution (DKR) of enamines and normal resolution of α,α‐disubstituted imines were developed. The corresponding substituted dihydropyridones were isolated in good yields with excellent diastereo‐ and enantioselectivities, and a high selective factor (up to 83) was realized for the resolution of α,α‐disubstituted imines.
Pursuing the question of reflexivity in psychotherapy and qualitative methods: The contributions of David L. Rennie
Authors: Levitt Heidi M. , Lu Ethan C. , Pomerville Andrew , Surace Francisco I.
Published: November 2018

Background

This article documents the intellectual contributions of the psychologist David Rennie to the fields of psychotherapy research, qualitative methods and humanistic psychology by tracing the central position of reflexivity across these bodies of work. This work had a profound influence on his field and led to his viewing the fostering of clients’ reflexivity as the central task of psychotherapy.

Aims

It follows his path as a researcher, beginning with his advancement of grounded theory methods and their application within psychotherapy research. His development of a humanistic experiential person‐centred approach to psychotherapy is described as an extension of this valuing of reflexivity and the recognition of the role of clients’ agency within sessions. In addition, the paper reviews the innovative methodological research that led him to propose a model of inferential processes that underlies qualitative research methods and that is rooted in the process of embodied reflexivity. His contextualising qualitative methods within a form of methodical hermeneutics permitted a unifying framework for understanding the logic of qualitative methods.
Long non‐coding RNA RUNX1‐IT1 plays a tumour‐suppressive role in colorectal cancer by inhibiting cell proliferation and migration
Authors: Shi Jinxin , Zhong Xi , Song Yongxi , Wu Zhonghua , Gao Peng , Zhao Junhua , Sun Jingxu , Wang Jiajun , Liu Jingjing , Wang Zhenning
Published: November 2018

Long non‐coding RNAs (lncRNAs) have been demonstrated to be involved in the progression of various cancers. In this study, we aim to investigate the role of lncRNA RUNX1‐IT1 in the development of colorectal cancer (CRC). The expression levels of lncRNA RUNX1‐IT1 were measured using quantitative real‐time Polymerase Chain Reaction(qRT‐PCR). CCK8 proliferation assay, transwell assay, and flow cytometry were performed to evaluate the effect of lncRNA RUNX1‐IT1 on CRC cell proliferation, migration, and apoptosis. The proliferation markers (PCNA, Ki67), apoptosis markers (cleaved‐PARP, cleaved‐caspase3), and MMP9 are detected by western blotting. Significant down regulation of lncRNA RUNX1‐IT1 was measured in CRC tissues and three CRC cell lines (HCT116, HT29, and RKO) compared with paired nontumorous adjacent tissues (P < 0.01) or the normal colonic epithelial cell line FHC (P < 0.05), respectively. Moreover, the proliferative and migration potential of CRC cells were inhibited by overexpressing lncRNA RUNX1‐IT1, which could be obviously improved by knocking down lncRNA RUNX1‐IT1. The protein levels of PCNA, Ki67, and MMP9 were upregulated by overexpressing lncRNA RUNX1‐IT1 and down regulated in si‐RUNX1‐IT1 cells. Besides, lncRNA RUNX1‐IT1 could also promote the apoptosis of CRC cells. In conclusion, lncRNA RUNX1‐IT1 is downregulated in CRC and plays a tumour‐suppressive role due to the regulatory of cell proliferation, migration, and apoptosis.

Significance of the study

We demonstrated that lncRNA RUNX1‐IT1 was down regulated both in CRC tissues and cell lines. Besides, lncRNA RUNX1‐IT1 could serve as a potential diagnostic biomarker and play a tumour‐suppressive role owing to its good diagnostic efficacy and inhibition of CRC cell proliferation and migration.
Novel Dextran‐Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate–Protein Interactions of Gal‐3
Authors: Rahkila Jani , Ekholm Filip S. , Ardá Ana , Delgado Sandra , Savolainen Johannes , Jiménez‐Barbero Jesús , Leino Reko
Published: November 2018

The quest for novel natural‐like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates by proteins modulates a number of important biological processes. These molecular recognition events are, however, difficult to study by the use of naturally occurring oligosaccharides and polysaccharides owing to their intrinsic structural heterogeneity and to the many technical difficulties encountered during the isolation of sufficient quantities of pure material for detailed structural and biological studies. Therefore, the construction of homogenous biomolecular probes that can mimic both the biophysical properties of polysaccharide backbones and the properties of bioactive oligosaccharide fragments are highly sought after. Herein, synthetic methodology for the construction of well‐defined bioconjugates consisting of biologically relevant disaccharide fragments grafted onto a dextran backbone is presented, and a preliminary NMR spectroscopy study of their interactions with galectin‐3 as a model lectin is conducted.