bluuebunny/crossref_metadata_2025 huggingface dataset:
Two Cases of 18F-FDG-PET/CT Positive Schloffer Tumor Requiring Differentiation from Local Recurrence of Colon Cancer
Authors: UEHARA HIROKI , Hamada Madoka , HATTA MASAHIKO , SEKIMOTO MITSUGU , NODA YURI , MINAMI KOTARO , KONO YUMIKO , KUROKAWA HIROAKI
Published: September 2022

We report two cases of Schloffer tumor that required resection after
radical colon cancer surgery because of suspected lymph node recurrence
on contrast-enhanced (CE) CT and 18F-FDG-PET/CT.Case1 is 69-year-old man
with sigmoid colon cancer pStage IIA and case 2 is a 67-year-old male
with descending colon cancer pStage IIIB.
Epigallocatechin-3-gallate enhances sterilization of irradiated whole bovine casein and protects alpha and beta caseins from gamma radiation: depending on polyphenol/protein ratio
Authors: Sahbani Saloua Kouass , Trifi Beyram , Kouas Salah
Published: September 2022

The increasing use of milk proteins in medicine requires the development
of effective processes for sterilization of milk formulations. We found
that epigallocatechin-3-gallate (EGCG) was able to reduce bacterial
flora in total casein, depending on the concentration of EGCG.
Furthermore, the combination of EGCG and gamma radiation reduced the
dose D10 to 0.88 kGy and 0.63 kGy with 250 and 500 µM EGCG,
respectively, instead 2.01 kGy without EGCG. We also examined the effect
of gamma radiation on alpha- and beta-casein in the absence and presence
of epigallocatechin-3-gallate (EGCG). Milk proteins in solution were
exposed to different doses of gamma radiation with and without EGCG.
Unirradiated and irradiated samples were analyzed by SDS-PAGE and
matrix-assisted laser desorption ionization time-of-flight mass
spectrometry (MALDI-MS). Our results suggest that EGCG (10 µM) protects
α- and β-casein from degradation and subsequent polymerization, possibly
by scavenging oxygen and protein free radicals generated during
irradiation. Although we used a ratio of polyphenols to protein that was
higher for alpha-casein (1/5) than beta-casein (1/10), beta-casein was
better protected with EGCG. According to previous studies, this result
could be explained by differences in protein primary structure and its
interaction with EGCG. The interaction of EGCG with casein is
hydrophobic rather than hydrophilic, so the interaction with β-casein is
stronger than with α-casein. In conclusion, we found that low EGCG
concentrations enhances the sterilization of total casein by gamma
radiation and it provided an excellent radioprotection of α- and
β-casein, especially β-casein, against degradation and aggregation.
Rituximab successful in COVID-19 vaccine-induced refractory pemphigus vulgaris
Authors: HUI Hai-Zhen , WANG Ying-Jun , CHENG Jia-Rong , MAO Han , GUO Hong-Xing , SHI Bingjun
Published: September 2022

Coronavirus disease 2019 (COVID-19) is the most prevalent disease in
society today, and vaccination is a powerful weapon against COVID-19.
However, there have been many recent reports of vaccine-induced skin
side effects. Autoimmune bullous reactions caused by the COVID-19
vaccine are rare. We identified a case of refractory PV associated with
COVID-19 vaccination that improved after 2 RTX injections.
Requirement Engineering in Learning Analytics (Machine Learning) in an Indigenously Designed Learning Platform: A Case Study
Authors: Adewusi Michael Adelani , Odekeye Tokunbo , Eniola Silas Egbowon , Rahman Alade , Akindoju Olugbenga Gabriel
Published: September 2022

Examination of data from a variety of sources could be a very effective tool for needs elicitation and management (Franch, 2020) and an indigenously developed platform for learning purposes should not be excluded or ignored (Adewusi, Egbowon & Akindoju, 2021). With the use of natural language processing or machine learning in analysing, data are tough to grasp since they necessitate high-quality data and specialised knowledge from several domains, and more importantly, their generalisation remains a difficult task (Franch, 2020). Although data-driven approaches are becoming more prevalent in practically every aspect of software development and or engineering, the issue of requirement engineering is still not being addressed to ensure that designed software, particularly indigenous applications, is appropriate to the end-users such as parents, government and stakeholders in all educational sector all over the world. However many countries shut down their schools in a bid to avoid the spread of COVID-19. This Chapter examines Requirement Engineering in Learning Analytics (Machine Learning) in an Indigenously Designed Learning Platform using a Case Study Keywords: Requirement Engineering, Learning Analytics, Machine Learning
Where Do I Start? A Pathway for Personal Growth for Faculty Committed to Creating Inclusive Classrooms
Authors: Bishop-Monroe Robbie , Garcia Joanna L.
Published: September 2022

This commentary offers insights into how accounting faculty can begin to create more inclusive, equitable experiences for students. Many faculty are well intentioned and desire to improve the student experience but may not know where to start. We introduce a pathway of reflection, education, and action that we believe can help faculty get started on this process. Reflection is the process of assessing one’s own identity, influences, biases, and personal experiences with diversity and privilege. Education involves seeking out information and experiences that can enhance cultural competence, particularly around gaps identified through reflection. Action refers to practical steps taken to make classrooms more inclusive, including classroom management and curricular changes. We draw upon professional experiences in academia and personal knowledge as authors with diverse racial and ethnic backgrounds to guide faculty interested in beginning to develop more inclusive classrooms.
The Future of Continuous Glucose Monitoring
Authors: Battelino Tadej
Published: September 2022

The historical vision for continuous glucose monitoring (CGM) is becoming reality in day-to-day diabetes management, with the prospect of rapid growth in the foreseeable future. The latest U.S. Food and Drug Administration (FDA) approval of the first factorycalibrated CGM sensor will strengthen the path toward total elimination of cumbersome manual CGM calibrations.
Herpes Zoster Incidence and Burden in Adults With Type 2 Diabetes in the U.S.: A Retrospective Database Analysis
Authors: Poirrier Jean-Etienne , Meyers Juliana L. , Nagar Saurabh P. , Patterson Brandon J. , Glasser Lisa I. , Jabbour Serge A.
Published: September 2022

OBJECTIVE

Data on the real-world burden of herpes zoster (HZ) in adults with type 2 diabetes (T2D) in the U.S. are limited. We assessed HZ in patients with and without T2D and measured the impact of HZ on health care resource use (HCRU) and costs.

RESEARCH DESIGN AND METHODS

This retrospective cohort analysis used U.S. commercial claims data (sourced from claims incurred between 1 January 2012 and 31 July 2018). HZ incidence rates/1,000 person-years (PYs) were calculated in patients with and without T2D. HZ risk was evaluated using Poisson regression to generate adjusted incidence rate ratios (aIRRs). Patients with T2D with HZ were propensity score matched to patients with T2D only and to patients with HZ without T2D. HCRU and costs were compared across cohorts during a 1-year follow-up period. Cox proportional hazards analyses evaluated factors associated with HZ-related complications.

RESULTS

Crude HZ incidence rates in patients with and without T2D were 9.8/1,000 PY and 2.6/1,000 PY, respectively. T2D patients were almost twice as likely to be diagnosed with HZ (aIRR 1.84; 95% CI 1.82–1.85). HZ was associated with increased HCRU and health care costs. At 12 months, unadjusted incremental all-cause health care costs for patients with T2D with HZ versus patients with T2D without HZ were $5,216. The unadjusted incremental HZ-related health care costs for patients with T2D with HZ versus patients with HZ without T2D were $2,726. Age was the most important predictor for HZ-related complications.

CONCLUSIONS

Given the increased risk of HZ and HCRU and cost burden in patients with T2D, HZ prevention in patients with T2D may be beneficial.
Systematic review and network meta-analysis of neurostimulation for painful diabetic neuropathy
Authors: Duarte Rui V. , Nevitt Sarah , Copley Sue , Maden Michelle , Vos Cecile C de , Taylor Rod S , Eldabe Sam
Published: September 2022

  

Background: Different waveforms of spinal cord stimulation (SCS) have now been evaluated for the management of painful diabetic neuropathy (PDN). However, no direct or indirect comparison between SCS waveforms has been performed to date.

Purpose: To conduct a systematic review and network meta-analysis (NMA) to evaluate the effectiveness of SCS for PDN.

Data sources: MEDLINE, CENTRAL, Embase and WikiStim were searched from inception until December 2021.

Study selection: Randomised controlled trials (RCTs) of SCS for PDN were included.

Data extraction: Pain intensity, proportion of patients achieving at least a 50% reduction in pain intensity and health-related quality-of-life (HRQoL) data were extracted.

Data synthesis: Significant reductions in pain intensity were observed for low-frequency SCS (LF-SCS) (mean difference [MD] -3.13, 95% confidence interval [CI] -4.19 to -2.08, moderate certainty) and high-frequency SCS (HF-SCS) (MD -5.20, 95% CI -5.77 to -4.63, moderate certainty) compared to conventional medical management (CMM) alone. There was a significantly greater reduction in pain intensity on HF-SCS compared to LF-SCS (MD -2.07, 95% CI -3.26 to -0.87, moderate certainty). Significant differences were observed for LF-SCS and HF-SCS compared to CMM for the outcomes proportion of patients with at least 50% pain reduction and HRQoL (very low to moderate certainty). No significant differences were observed between LF-SCS and HF-SCS (very low to moderate certainty).

Limitations: Limited number of RCTs and no head-to-head RCTs conducted.

Conclusions: Our findings confirm the pain relief and HRQoL benefits of the addition of SCS to CMM for patients with PDN. However, in the absence of head-to-head RCT evidence the relative benefits of HF-SCS compared to LF-SCS for patients with PDN remains uncertain.
Risk of reoperation due to surgical site infection in 74,771 hip fracture patients: a Danish nationwide cohort study
Authors: Kristensen Nicolai K , Lange Jeppe , Frøslev Trine , Pedersen Alma B
Published: September 2022

Background and purpose: Surgical site infection (SSI) after hip fracture surgery is a feared condition. We examined the trend in incidence of reoperation due to SSI up to 1 year following hip fracture surgery from 2005 to 2016 and risk factors of SSI by age, sex, comorbidity, type of fracture, and surgery.Patients and methods: We conducted a population-based, nationwide cohort study using data from the Danish Multidisciplinary Hip Fracture Register (DMHFR). We included 74,771 patients aged 65 and up who underwent surgery from 2005 to 2016 for all types of hip fracture. We calculated net risk of reoperation using Kaplan–Meier method, and, with Cox regression, adjusted hazard ratios (HRs) with a 95% confidence interval (CI) for reoperation due to SSI.Results: Overall, the 1-year net risk of reoperation due to SSI was 1.6%. The HR was higher for patients undergoing total/hemiarthroplasty surgery versus internal fixation (HR = 1.5; 95%CI 1.3–1.8) and lower for patients with per-/subtrochanteric fracture versus femoral neck fracture (HR = 0.6; CI 0.6–0.7). The risk of reoperation due to SSI decreased over time; HR was 0.7 (CI 0.5–0.8) for 2015–2016 compared with 2005–2006. Risk of reoperation decreased with increasing age; the HR was 0.8 (CI 0.7–1.0) in the more than 85-year-olds compared with 65–74-year-old patients. Charlson Comorbidity Index of ≥ 3 was associated with a higher risk of reoperation due to SSI, HR was 1.3 (CI 1.1–1.6).Interpretation: The net risk of reoperations due to SSI in our study was lower than previously assumed. We identified several risk factors for increased risk of reoperation due to SSI, most noticeably treatment with arthroplasty vs. internal fixation, as well as younger age, high comorbidity burden, and femoral neck fracture diagnosis.
This is version 2 of this manuscript with all corrections included, see Corrigendum, doi: 10.2340/17453674.2022.5357
Relações entre matemática e filosofia na emergência da matemática pura: a matemática como fundamento da pensabilidade
Authors: Linder Vinicius , Schubring Gert
Published: September 2022

Neste artigo, investigamos as tensões e ingerências entre filosofia e matemática no contexto da emergência da matemática pura na Prússia, no século XIX. É bem conhecida, na historiografia, a ocorrência de uma virada epistemológica na matemática nesse século, que viria a reestruturar as concepções internas de seus objetos, em detrimento de uma noção quantitativa e a partir de uma concepção relacional. Argumentamos aqui que essa mudança perpassa, justamente, o entendimento kantiano de que, ao lidar com juízos sintéticos a priori, a matemática se conceberia como fundamento da pensabilidade. Nosso percurso então se faz por meio da investigação de manifestações dessas noções nos trabalhos de dois autores: Jakob Fries, filósofo da ciência e da matemática do início do século, e Hermann Grassmann, matemático, cuja obra viria a influenciar novas concepções na segunda metade do século. Nossa pesquisa identifica, nas perspectivas e práticas de Fries e Grassmann, uma unidade conceitual, em torno da reflexão fundacional da matemática a partir de estruturas abstratas do pensar. Essa constatação revela, por outro lado, a intervenção de práticas e referências filosóficas no interior da prática matemática, produzindo tensões e abarcando um relevante papel na mudança epistemológica em questão.
Programa Teoria da Educação Matemática (TEM) de Hans-Georg Steiner: aspectos filosóficos e epistemológicos
Authors: Santos Marluce Alves dos , Ag Almouloud Saddo
Published: September 2022

Discute-se sobre o Programa Teoria da Educação Matemática (TEM), criado por Hans-Georg Steiner, em seus aspectos filosóficos e epistemológicos, e nove ideias e seis teses que nasceram da preocupação em sistematizar teorias e metodologias para a pesquisa em Educação Matemática, e o seu estabelecimento como disciplina científica. O percurso metodológico realizado foi a revisão bibliográfica nos textos escritos pelo autor. Conclui-se que nos últimos 10 anos não parece ter havido muito progresso sobre o pensamento expresso nas pesquisas delineadas por Hans-Georg Steiner para o Programa Teoria da Educação Matemática. Entretanto, destaca-se que há breve discussão sobre a construção de quadro comparativo das visões da Educação Matemática como disciplina científica e como seria este desenvolvimento diante da possibilidade de casos produzidos por meta pesquisas.
Celestial Aspirations
Authors: Hardie Philip
Published: September 2022

Between the late sixteenth century and early nineteenth century, the British imagination—poetic, political, intellectual, spiritual and religious—displayed a pronounced fascination with images of ascent and flight to the heavens. This book explores how British literature and art during that period exploited classical representations of these soaring themes—through philosophical, scientific and poetic flights of the mind; the ascension of the disembodied soul; and the celestial glorification of the ruler. From textual reachings for the heavens in Spenser, Marlowe, Shakespeare, Donne and Cowley, to the ceiling paintings of Rubens, Verrio and Thornhill, the book focuses on the ways that the history, ideologies and aesthetics of the postclassical world received and transformed the ideas of antiquity. In England, narratives of ascent appear on the grandest scale in Milton's Paradise Lost, an epic built around a Christian plot of falling and rising, and one of the most intensely classicizing works of English poetry. Examining the reception of flight up to the Romanticism of Wordsworth and Tennyson, the book considers the Whig sublime, as well as the works of Alexander Pope and Edward Young. Throughout, the book looks at motivations both public and private for aspiring to the heavens—as a reward for political and military achievement on the one hand, and as a goal of individual intellectual and spiritual exertion on the other.
Nationalisms in International Politics
Authors: Powers Kathleen E.
Published: September 2022

With nationalism on the rise around the world, many worry that nationalistic attitudes could lead to a surge in deadly conflict. To combat this trend, federations like the European Union have tried to build inclusive regional identities to overcome nationalist distrust and inspire international cooperation. Yet not all nationalisms are alike. This book draws on insights from psychology to explore when nationalist commitments promote conflict—and when they foster cooperation. Challenging the received wisdom about nationalism and military aggression, the book differentiates nationalisms built on unity from those built on equality, and explains how each of these norms give rise to distinct foreign policy attitudes. Combining innovative US experiments with fresh analyses of European mass and elite survey data, the book argues that unity encourages support for external conflict and undermines regional trust and cooperation, whereas equality mitigates militarism and facilitates support for security cooperation. The book provides a rigorous and compelling look at how different forms of nationalism shape foreign policy attitudes and raises important questions about whether transnational identities increase support for cooperation or undermine it.
Partisipasi Masyarakat Dalam Pembangunan Infrastruktur Jalan Di Desa Kaligintung Kecamatan Temon Kabupaten Kulon Progo 2019
Authors: Ismatullah Ismatullah , Mahendra Gerry Katon
Published: September 2022

Undang-undang No 23 tahun 2014 pasal 1 ayat 41 menjelaskan bahwa partisipasi masyarakat adalah sebuah peran serta masyarakat dalam menyalurkan aspirasi, pemikiran dan kepentingan dalam penyelenggaraan pemerintah daerah. Partisipasi masyarakat dalam subjek pembangunan merupakan upaya untuk mewujudkan tujuan pembangunan nasional.. Dalam hal ini, penelitian ini akan membahas tentang partisipasi masyarakat dalam pembangunan infrastruktur jalan di Desa Kaligintung Kecamatan Temon Kabupaten Kulon Progo 2019. Terdapat empat jenis partisipasi di Desa Kaligintung yaitu (1) partisipasi dalam pengambilan keputusan, (2) partisipasi dalam pelaksanaan, (3) partisipasi dalam pengambilan manfaat dan (4) partisipasi dalam evaluasi. Selanjutnya faktor partisipasi masayarakat dalam pembangunan infrastruktur di Desa Kaligintung dipengaruhi oleh beberapa faktor pendukung dan terdapat pula faktor penghambat. Pada faktor pendukung terdapat tiga faktor yaitu faktor ekonomi, faktor kesadaran, faktor pendidikan. Sedangkan faktor penghambatnya adalah menggunakan bahu jalan desa untuk kepentingan pribadi, namun faktor ini tidak menjadikan tertundanya pembangunan infrastruktur jalan Desa Kaligintung.
Dampak Media Sosial Bagi Perubahan Perilaku Generasi Muda di Masa Pandemi Covid-19
Authors: Arianto Bambang
Published: September 2022

Artikel ini bertujuan mengelaborasi dampak media sosial terhadap perubahan perilaku generasi muda dalam aktivitas keseharian di masa pandemi Covid-19. Hal itu disebabkan generasi muda memiliki ketergantungan yang tinggi terhadap media sosial sebagai saluran komunikasi digital dan sarana mencari informasi terkini. Ketergantungan ini telah menciptakan dampak positif dan negatif bagi perubahan perilaku generasi muda. Dampak positif tampak dari perilaku generasi muda yang tampil lebih kreatif dan partisipatif dalam setiap aktivitas. Sedangkan dampak negatif yang diciptakan justru dapat membuat terlembaganya aksi perundungan (bullying) dan terjadinya depresi akibat tidak mampu meniru segala aktivitas yang lagi populer di media sosial. Penelitian ini menggunakan pendekatan studi kepustakaan (literatur review) dalam mengelaborasi topik penelitian. Penelitian ini menyatakan ketergantungan terhadap media sosial bagi generasi muda telah mendorong perubahan perilaku yang positif dan negatif. Penelitian ini juga menyatakan bahwa diperlukan upaya pencegahan dari adanya dampak negatif media sosial melalui penguatan literasi digital.
Manajemen Bencana Dalam Penanganan Pasca Bencana BPBD Kabupaten Aceh Barat
Authors: Rahmah Selvia , Ikhsan Ikhsan
Published: September 2022

This study aims to see how the post-disaster management carried out by the BPBD of West Aceh Regency in post-disaster handling. This study uses a qualitative method with a case study approach. The theory used about disaster management, there are 3 stages with indicators of post-disaster rehabilitation and reconstruction coverage, namely (1) Pre-Disaster, (2) During the Event, and (3) Post-Disaster. The results indicate that the Disaster Management of West Aceh District BPBD in Post-Disaster Handling has generally been carried out well. This rehabilitation and reconstruction process was carried out according to data sources from informants who worked at the BPBD of West Aceh Regency from 2017 to 2021. In 2022, the rehabilitation and reconstruction process is not carried out because considering the disaster that occurred in this year there is no need for a rehabilitation process and also budget problems which are obstacles in carrying out the post-disaster management process.
Identificación de clústeres en la Zona Metropolitana de Guadalajara: restaurantes
Authors: Luquín-García Dolores , Fong Reynoso Carlos
Published: September 2022

El objetivo de este artículo es identificar la metodología de clusterización más apropiada para aplicarse en el sector restaurantero de la Zona Metropolitana de Guadalajara (ZMG). Se llevó a cabo un recuento de las distintas técnicas de clusterización espacial, para después identificar que la más conveniente es la técnica de Kulldorff, la cual fue utilizada para mapear los clústeres de los restaurantes existentes en la metrópoli. Los resultados muestran diez clústeres de restaurantes en la ZMG, siete de ellos con alta concentración de unidades económicas. El presente estudio es innovador respecto a la detección de clústeres en la industria restaurantera de la ZMG.
Celebración a la trayectoria de Manuel Ángel Castillo
Authors: Garza Gustavo , Rojas Martha , Nájera Jéssica , Argüelles Leticia , Giorguli Silvia , Sánchez Landy , Castillo Manuel Ángel , Molina María Isabel
Published: September 2022

El Colegio de México, a través del Centro de Estudios Demográficos, Urbanos y Ambientales (CEDUA), organizó una Celebración a la Trayectoria de Manuel Ángel Castillo. El homenaje se llevó a cabo en la Sala Alfonso Reyes de la institución, el 5 de abril de 2022. Participaron Gustavo Garza (Programa de Estudios Interdisciplinarios, Colmex), Martha Rojas (El Colegio de la Frontera Sur), Jéssica Nájera (CEDUA, Colmex), Leticia Argüelles (editora de Estudios Demográficos y Urbanos, CEDUA, Colmex), Silvia Giorguli (presidenta de El Colegio de México), María Isabel Molina (esposa del homenajeado) y, por último, Manuel Ángel Castillo, quien pronunció unas palabras de agradecimiento. El acto fue organizado y moderado por Landy Sánchez (directora del CEDUA). A continuación, incluimos las participaciones de los expositores, en el orden de su presentación.
Tipos de processamento no consumo alimentar de alunos universitários
Authors: Gomes Heitor Moreira , Guimarães Laurieny Kethelen , Conceição Rodrigo Barboza , Nogueira Carla Ribeiro
Published: September 2022

ObjetivoAvaliar universitários através de questionário de frequência alimentar (quantitativo e qualitativo) e classificar a ingestão de alimentos de acordo com o tipo de processamento.MétodosTrata-se de um estudo transversal observacional, em que foi enviado um questionário para os alunos dos cursos de Nutrição, Educação Física, Enfermagem, Administração, Farmácia, Psicologia, Engenharia Civil e Fisioterapia da Instituição de Ensino Superior Universidade Salgado de Oliveira, Rio de Janeiro. Foram coletadas as seguintes informações: curso, sexo e o consumo alimentar nas refeições diárias, separadas por porções: desjejum, colação, almoço, lanche da tarde, jantar e ceia. Em seguida, os alimentos que os estudantes relataram consumir foram separados em quatro categorias: in natura; minimamente processado; processado e ultraprocessado, baseando-se nas nomenclaturas do Guia Alimentar Brasileiro.ResultadosForam coletados dados de 201 alunos, o equivalentes a 5% dos alunos matriculados nos cursos de Nutrição, Educação Física, Enfermagem, Administração, Farmácia, Psicologia, Engenharia Civil e Fisioterapia da Universidade Salgado de Oliveira. Observou-se um alto consumo de alimentos processados na amostra como um todo, porém de forma mais expressiva pelos alunos do curso de Engenharia Civil. Em contrapartida, o maior consumo de alimentos in natura e minimamente processados foi declarado pelos alunos do curso de Educação Física.ConclusãoAs análises mostraram que o consumo alimentar dos alunos do curso de Educação Física era mais saudável em termos de processamento, possivelmente devido ao cuidado maior desses alunos com a saúde física. Já os alunos do curso de Engenharia Civil consumiam mais alimentos ultraprocessados. O consumo prolongado de alimentos ultraprocessados e processados aumenta o risco de desenvolvimento de doenças crônicas não transmissíveis, levando a um maior risco de mortalidade em longo prazo.
Comparison of Survival Outcomes between Early Breast Cancer Patients who Underwent Mastectomy and Patients Treated by Breast Conserving Therapy: A Meta Analysis
Authors: Manirakiza Astère , Irakoze Laurent , Manirakiza Sébastien
Published: September 2022

Background: Early stage of breast cancer requires mastectomy or breast conserving therapy. However, there are disagreements regarding the outcome of these two types of therapies in term of overall survivals. Objectives: The first aim of this meta-analysis was to assess the overall survival between patients who underwent mastectomy and those treated by breast conserving therapy. The second was to evaluate the influence of the follow up period on overall survival between the patients who benefited mastectomy and those who under went breast conservative therapy. Methods: We systematically searched on PubMed and Cochrane library all published randomized trials comparing mastectomy with breast conserving therapy and assessing overall survival. Results: Using dichotomous data, there was no significant difference between mastectomy and BCT(OR:0.99; 95% CI:0.93-1.06; P:0.86). This was the same in subgroup analysis based on period of follow up. Their ORs and CI were (OR:0.97; 95% CI:0.81-1.18; P:0.79), (OR:1.01; 95% CI:0.90-1.13; P:0.87) and (OR:1.04; 95% CI:0.93-1.16; P:0.46) respectively for up to 5 years or less, between 5 and 10 years and more than 10 years of follow up. Using generic inverse variance, there was no significant difference between mastectomy and BCT, (HR:1.01; 95% CI:0.98-1.04; P:0.71). In subgroup analysis based on period of follow up, there was no significant difference between mastectomy and BCT. Their HRs, CI and P-value were (HR:1.01; 95% CI:0.951-1.07; P:0.79), (HR:0.98; 95% CI:0.92-1.04; P:0.51) and (HR:1.02; 95% CI:0.97-1.07; P:0.40) respectively for up to 5 years or less, between 5 and 10 years and more than 10 years of follow up. Conclusion: This meta-analysis demonstrated that there was no significant difference between patients with early stage breast cancer when they are treated by mastectomy or breast consevative therapy in term of overall survival. Additionnally, the follow up period had no any influence on the both types of surgery in term of overall survival. Therefore, we suggest that breast conservative therapy or mastectomy should be discussed between the care team and the patient, taking into account the financial means available to the patient, especially in low-income countries, the benefits of the surgery and the patient’s choices.
Challenges in Diagnosis and Management of Second Trimester Omental Pregnancy in Limited Resource Settings: Case Report
Authors: Mushema Beata Nyangoma , Nkwama Beno Steven , Rweyemamu George Alcard RweyemamuGeorge Alcard , Makanda Isaac Hamis , Chiduo Monica
Published: September 2022

Background: Abdominal pregnancies are a rare occurrence and are associated with high maternal and perinatal mortality rates compared to intra-uterine and other ectopic pregnancies. Localization of sites of abdominal pregnancies and determining the gestational age at the time of diagnosis play a fundamental role in guiding the treatment approach and minimizing potential complications. However, the vague presentation coupled with low accuracy of ultrasound detection often leads to misdiagnosis of abdominal pregnancy, and hence delaying initiation of appropriate management. We present a case of a second trimester abdominal pregnancy detected following failure of induction for an initial diagnosis of missed abortion, and the ensuing outcome, rarely reported in limited-resource settings. Case presentation: A 19 year old unbooked woman, gravida 2 para 1 at 17thweek gestation age by ultrasound presented with loss of foetal movement for one week. Based on clinical assessment and referral ultrasound findings, she was initially diagnosed with missed abortion and planned for induction. Failure of induction prompted a repeat ultrasound which revealed a non-viable abdominal pregnancy. Laparotomy was done, localisation of the pregnancy at the omentum was observed and a dead foetus was extracted with the placenta left in-situ. A complication of surgical wound dehiscence with infection developed post-operatively and was managed with secondary sutures. The patient recovered and was discharged in a stable condition. Conclusion: This case demonstrates that the diagnosis of abdominal pregnancy remains a challenge especially in settings where skilled human resources for health are few and equipment and supplies for effective and timely treatment are limited. The case sheds some light on the broader challenges in maternal and perinatal health in developing countries. Accurate pre-operative diagnosis requires a high index of suspicion, especially due to the variability of its presentation. This case emphasises the important of quality antenatal care and the need for clinicians to conduct comprehensive assessments of patients and receive training on obstetric ultrasound skills.
Inhaler Non-Adherence, Associated Factors and Asthma Control among Asthma Patients in a Tertiary Level Hospital in Tanzania
Authors: Shayo Grace A. , Omary Amina , Mugusi Ferdinand
Published: September 2022

Background: Inhaled medications including corticosteroids are the most effective long-term controller medicines for asthma-related chronic airway inflammation. Despite this fact, 30% to 70% of the uncontrolled asthma patients report non-adherence to their inhalers. The study investigated factors affecting inhaler non-adherence among outpatient asthma patients in Muhimbili National Hospital, Dar es Salaam Tanzania and related the level of inhaler adherence to the extent of asthma control. Methods: A cross-sectional hospital-based study was conducted among patients with bronchial asthma in the pulmonology clinic of Muhimbili National Hospital in Dar-es-salaam, Tanzania. Patients’ demographic, clinical and socio-economic factors were collected using a structured questionnaire. Medication adherence was self-reported using a 10-item Test of Adherence to Inhalers (TAI) questionnaire. Adherence was gauged as good when the score was 50, intermediate (score 46-49) or poor (score ≤ 45). Asthma control was assessed using a 5-question Asthma Control Test (ACT). A score of ≥20 meant well controlled asthma while a score of ≤19 meant poorly controlled asthma. Patients’ inhaler use technique was assessed using a 12-step checklist. Patient’s technique was regarded correct when all the steps were performed correctly. Categorical data were summarised as proportions. Binary logistic regression was performed to identify factors associated with inhaler non-adherence. Significance level was set at p-value less than .05. Results: A total of 385 asthma patients were enrolled in the study. Females were 206 (53.5%), 232(60.3%) were nonadherent to medications and 283(73.5%) had poorly controlled asthma. Lack of health insurance, fear of medication side effects, being too busy, having alternative medication for asthma and incorrect inhaler technique were significantly associated with non-adherence to inhalers, all p-values <.05. Conclusion: The magnitude of inhaler non-adherence and poorly controlled asthma were very high. Promoting adherence through patients’ education on asthma and its management, emphasis on patients’ insurance coverage and setting aside time to care for ones’ self are fundamental in optimising asthma care and treatment.
Consumer Enforcement Opportunities – New Approaches and Trends in Hungarian Procedural Laws
Authors: Gombos Katalin , Pomeisl András J.
Published: September 2022

The European Union has put in place EU rules on consumer contracts and enforcement of consumer rights. These tendencies have also had a significant impact on the Hungarian legislation of recent years. We would describe some provisions of the new Hungarian Code of Civil Procedure concerning consumer enforcement and the Hungarian experience of Directive 93/13/EEC so far. The new Hungarian Code of Civil Procedure has reformed domestic rules on jurisdiction in the field of a consumer’s claim arising from a contractual relationship. The article also covers the following areas of law: Hungarian experience with foreign currency-based loan agreements, reforms to the preliminary ruling procedure in the new Hungarian Code of Civil Procedure.
Resolution of Cases for Consumer Protection under Civil Procedure in Poland. Selected Issues
Authors: Drozdowicz Krzysztof
Published: September 2022

The article addresses selected issues related to the resolution of cases for consumer protection under civil procedure in Poland. Although consumer law is mainly the domain of substantive civil law, in civil procedural law there are also normative solutions concerning this issue and they will be discussed in the article. The author will present new legal instruments aimed at increasing the effectiveness of consumer protection in civil proceedings, as well as the proposed changes that should be under debate.
Crosstalk between adipose tissue and the heart: An update
Authors: Li Chao , Sun Xue-Nan , Zhao Shangang , Scherer Philipp E.
Published: September 2022

It is important to understand how different human organs coordinate and interact with each other. Since obesity and cardiac disease frequently coincide, the crosstalk between adipose tissues and heart has drawn attention. We appreciate that specific peptides/proteins, lipids, nucleic acids, and even organelles shuttle between the adipose tissues and heart. These bioactive components can profoundly affect the metabolism of cells in distal organs, including heart. Importantly, this process can be dysregulated under pathophysiological conditions. This also opens the door to efforts targeting these mediators as potential therapeutic strategies to treat patients who manifest diabetes and cardiovascular disease. Here, we summarize the recent progress toward a better understanding of how the adipose tissues and heart interact with each other.
Handledning: en mångfacetterad arbetsallians
Authors: Anderlini Michel Vincent
Published: September 2022

Syfte med denna artikel är, utifrån mina erfarenheter som handledare i två olika kandidatprogram vid Malmö Universitet och dess policydokument, diskutera handledning som en mångfacetterad arbetsallians mellan handledare och handledda. Artikeln utforskar fem olika teman som är relevanta för handledning på grund- och avancerad nivå: olika handledarroller, emotionella band mellan handledare och den handledda, maktförhållanden i handledningsrelationer, gruppseminarier samt feedback. Artikeln visar att handledning innefattar en mängd olika roller och stilar som handledaren kan inneha, roller och stilar som behövas anpassas till varje student och över tid. Handledaren och den handledda behöver, av den anledningen, kontinuerligt reflektera över de olika aspekter av deras arbetsallians för att denna ska nå sin fulla potential.
Möjligheter, utmaningar och hinder
Authors: Larneby Marie
Published: September 2022

Syftet med föreliggande erfarenhetsbaserade reflektion är att diskutera i handledningsprocessen för uppsatser och självständiga arbeten på grund och avancerad nivå. I fokus står möjligheter, utmaningar och hinder i handledningsprocessen. Texten baseras främst på mina erfarenheter av handledning inom institutionen för idrottsvetenskap men tar även stöd i forskning och styrdokument. Institutionen för idrottsvetenskap är flervetenskaplig vilket bidrar till att flera olika vetenskapsteoretiska traditioner samsas på institutionen vilket leder till diskussioner när handledare har olika uppfattningar om och erfarenheter av forskningsprocessen. Detta kan förstås både som utmaningar, hinder och som möjligheter. Det är emellertid viktigare att vara expert på hantverket att strukturera en uppsats än att vara expert i ett ämne. En central del i handledningsprocessen är relationen mellan handledare och student, där olika aspekter av relationer och pedagogiskt ledarskap beaktas. Vidare diskuteras grupphandledning och enskild handledning.
Positive Predictive Value of Primary Subarachnoid Hemorrhage Diagnoses on Death Certificates
Authors: English Shane , Van Walraven Carl van Walraven
Published: September 2022

Purpose: Epidemiological studies of primary subarachnoid hemorrhage (pSAH) frequently include population-based death registries for case finding. The positive predictive value of pSAH diagnoses in death registries is unknown.Methods: This cross-sectional study identified all people in Ontario, Canada with pSAH listed as a cause of death between 2013 and 2017. pSAH was classified as “very likely” if diagnosis of pSAH was confirmed by autopsy, there was a previous hospitalization where pSAH probability exceeded 85% or death was preceded within a week by an emergency room visit where pSAH probability exceeded 25%. pSAH was classified as “very unlikely” if previous cerebrovascular imaging had never been done. Remaining cases were classified as “pSAH status unknown”.Results: 1,613 deaths attributed to pSAH were identified (mean 322/year). pSAH classification frequencies were as follows: very likely 528 (32.7%); very unlikely 433 (26.8%); and status unknown 652 (40.4%).Conclusion: We found that a quarter of pSAH cases in our province’s death registry were very unlikely to be true pSAH while 40% had unknown veracity. These data should be considered when using death registries for pSAH case finding.
Innovation input incentive policy and financialisation of entity enterprises: Evidence from the policy of additional deduction for R&D expenses
Authors:   School of Economics and Statistics, Guangzhou University, Guangzhou 510006, China, Sun Hui , Long Youyu ,   School of Business, Shaoguan University, Shaoguan 512005, China, Fu Yuanhai ,   School of Economics and Statistics, Guangzhou University, Guangzhou 510006, China, Peng Xiaozhun ,   Bank of Communications Dongguan Branch, Dongguan 523000, China
Published: September 2022

In the structure of business investment, the tendency of entity enterprises to financialise profoundly affects their incentive to invest in innovation. The question of whether and how innovation investment incentive policies can facilitate firms to adjust their investment capital structure more in favour of R&D innovation deserves attention. This paper empirically examines the impact and mechanism of innovation investment incentive policies on the investment structure of enterprises based on micro-operating data of listed A-share enterprises from 2009 to 2020, taking the R&D expense-plus deduction policy as an example. The study finds that: firstly, the R&D expense-plus-deduction policy significantly promotes firms' investment structure demand for engaging in R&D investment; secondly, its main mechanism comes from the reduced financialisation of entity enterprises, which further increases R&D investment under the incentive of strengthening firms' market capitalisation management capital and the level of risk-taking of firms; thirdly, the policy effect is subject to the effects of firm size, gearing, return on total assets, the nature of firm ownership, management shareholding shares, and firm age. The findings suggest that the innovation investment incentive policy promotes a more biased investment structure of firms towards R&D innovation and achieves the desired objectives of the policy.
Síndrome da dor patelofemoral: um estudo sob ampla perspectiva
Authors: Leão Lucas da Costa , Will Renata Cristine Chemim , Barini Bruno Finoti , Melo Lucas Borges de
Published: September 2022

Objetivo: Compilar os dados colhidos acerca da Síndrome da Dor Patelofemoral (SDPF) de forma a facilitar a busca de informações sobre o assunto. Revisão bibliográfica: A SDPF é uma queixa muito comum no consultório médico, caracterizada por uma dor na região anterior do joelho, desencadeada ou exacerbada por sobrecarga. Pode cronificar e dificultar a realização de atividades básicas do paciente e a prática de atividade física, mais incidente entre os adolescentes e indivíduos de meia idade e mais prevalente em mulheres, possui demora no diagnóstico. A melhor forma de prevenir a síndrome é identificar os fatores de risco modificáveis e intervir precocemente por meio de fortalecimento muscular de membros inferiores. Considerações finais: O tratamento deve ser individualizado e mantido por longos períodos em razão dos altos índices de recorrência e cronicidade, de forma a melhorar a qualidade de vida do paciente devido o impacto nas atividades rotineiras ocasionado pela patologia.
Using artificial intelligence in diabetic retinopathy
Authors: Mohan Sashwanthi , Gaur Ritika , Raman Rajiv
Published: September 2022

Diabetic retinopathy (DR), a microvascular complication of diabetes, is a leading cause of blindness in India. Regular and timely screening for DR is recommended for the early diagnosis and appropriate treatment. However, mass screening for DR poses a significant challenge. Artificial intelligence (AI) is an important tool which has been used for diagnosing and grading diabetic retinopathy and aids in mass DR screening thus helping in faster and earlier screening of DR. This article aims to describe how AI is used in DR, software that are available for screening and the limitations and challenges in implementation of AI in health-care settings.
Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis
Authors: Trai Nguyen Ngoc , Van Em Dang , Van Bui Thi , My Le Huyen , Van Tro Chau , Hao Nguyen Trong , Vu Hoang Anh , Tram Duong Bich , Van Thuong Nguyen , Doanh Le Huu
Published: September 2022

Background

Generalized pustular psoriasis (GPP) is a chronic disease associated with genetic factors related to mutations of the interleukin 36 receptor antagonist gene (IL36RN) and the caspase recruitment domain 14 gene (CARD14). However, the relevance of these mutations to the clinical features and severity of GPP remains unclear.

Aims

Our objective was to correlate the presence of IL36RN and CARD14 mutations with the clinical and laboratory findings in patients with GPP.

Methods

This cross-sectional descriptive study was conducted in 64 subjects with GPP. Clinical manifestations were recorded and the severity was graded as mild, moderate, or severe. Routine laboratory tests were performed and blood samples were collected for Sanger sequencing. The clinical data of patients were compared among the different mutation groups.

Results

The two main variants of IL36RN were c.115+6T > C (p.Arg10ArgfsX1) and c.227C > T (p.Pro76Leu). The major CARD14 mutations were c.2458C > T (p.Arg820Trp), c.1641C > T (p.Arg547Ser), and c.1753G > A transitions.

Provocative factors were uncommon in the group with both IL36RN and CARD14 mutations. Drugs (unspecified), especially herbals, were the most common triggers. A history of psoriasis was frequent in patients with only CARD14 mutations, but fever was uncommon. The c.1641C > T mutation was associated with leukocytosis > 15000/mm3 and the c.1753G > A mutation was associated with hypoalbuminemia <3.8g/dL.

Both the c.115+6T > C and c.227C > T variants of IL36RN were associated with fever ≥38.5°C while the c.115+6T > C variant was also associated with geographic tongue.

No gene mutations were associated with the total severity and severity grades.

Limitations

Four patients without the two major IL36RN mutations were excluded from the study.

Conclusion

The presence of IL36RN and CARD14 mutations were associated with a history of psoriasis, various provocative factors, fever, leukocytosis, hypoalbuminemia, and geographic tongue. Further studies to explore the role of these mutations in therapeutic efficacy and disease outcomes are necessary.
The crux of helix curvature: A potential surface landmark for the anterior border of the sigmoid sinus in minimally invasive presigmoid approaches
Authors: Hoz Samer S. , Palmisciano Paolo , Algburi Hagar A. , Sharma Mayur , Ismail Mustafa , Andaluz Norberto
Published: September 2022

Background:

Surgical landmarks are widely used across all surgical specialties to assist surgeons in accurately estimating the deep anatomical structures. We describe the crus of helix curvature as a potential indicator for the anterior border of the sigmoid sinus (SS) in the setting of minimally invasive presigmoid approaches.

Methods:

Anatomy investigations were performed on injected cadaveric heads to identify consistent surface surgical landmarks estimating the curse of the SS.

Results:

Presigmoid mastoid was noted in the center of the skin incision in 100% of the specimens. The crus of helix curvature was superimposed on the anterior border of the SS on 6 sides (60%). On the other four sides, the curvature lays within 5 mm of the anterior SS border (40%).

Conclusion:

For the minimally invasive presigmoid approaches, the “crus of helix curvature” can be used as a landmark for the anterior border of the SS, which can aid in the speed and safety of the procedure. The ease of use of this landmark makes it particularly convenient for physicians early in training.
Spatial Distribution of the Energy Resource by Thermal Gradient in the Mexican Seas
Authors: Alatorre Mendieta Miguel Ángel , n Hernández Contreras Ricardo Efraín , Pérez Pérez Armando Alonso , Mondragón Sánchez Leonora Fernanda
Published: September 2022

This work shows the first version of the Spatial Distribution of the Energy Resource by Ocean Thermal Gradient, where its availability is presented at 500, 750 and 1000 m depth within the exclusive economic zone. from Mexico. This work includes maps of surface temperature, subsurface temperature, temperature difference and net electric power at three different moments: the minimum, the maximum and the historical average. In addition, hypsometry and bathymetry maps are included, as it is one of the main criteria for installing an OTEC plant.
Dissociation Rate Calculation via Constant Force Molecular Simulation
Authors: Iida Shinji , Kameda Tomoshi
Published: September 2022

Steered molecular dynamics (SMD) simulation has been applied to molecular dissociation events by adding harmonic forces to molecules, and within most SMDs, molecules are pulled at a constant velocity. Instead of the constant-velocity pulling, a constant force can also be utilized in SMD, which we call constant-force SMD (CF-SMD) simulation. CF-SMD employs a constant force that reduces activation barriers, enhancing a dissociation event. Here, we present the capability of CF- SMD simulation to estimate a dissociation rate in equilibrium. We performed all-atom CF-SMD simulations for an NaCl system and protein-ligand systems, producing dissociation rates under various forces. We extrapolated them to the dissociation rate in the absence of a constant force, using Dudko-Hummer-Szabo model. We demonstrated that CF-SMD simulations combined with the model predicted a dissociation rate in equilibrium. CF-SMD simulation would be a powerful tool to estimate dissociation rate in a direct and computationally efficient manner.