bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of Sensory Analysis with Physical Textural Data from a Computerized Penetrometer in the Washington State University Apple Breeding Program
Authors: Evans Kate , Brutcher Lisa , Konishi Bonnie , Barritt Bruce
Published: December 2018

Selecting for crispness instrumentally in fruit from apple (Malus ×domestica) breeding programs is notoriously difficult. Most breeders rely on sensory assessment for this important characteristic. Following the 2009 harvest, we used a computerized penetrometer to assess firmness and texture of apple selections from the Washington State University's apple breeding program and 16 standard reference varieties. Data were compared with sensory data from the apple breeding team. In addition to the expected high correlations between the various firmness measures of the computerized penetrometer and the sensory firmness values, our data also show a significant correlation between the computerized penetrometer crispness value and the sensory crispness value, thus demonstrating the benefit from using this equipment rather than the industry standard Magness–Taylor penetrometer.
Effect of Mulching on Plant and Weed Growth, Substrate Water Content, and Temperature in Container-grown Giant Arborvitae
Authors: Amoroso Gabriele , Frangi Piero , Piatti Riccardo , Fini Alessio , Ferrini Francesco
Published: December 2018

This research evaluated the effectiveness of biodegradable mulches for weed control in container-grown ‘Martin’ giant arborvitae (Thuja plicata) and measured the effects of these mulches on evaporation and substrate temperature. The experiment was carried out in the 2008 and 2009 growing seasons. Four biodegradable mulching materials were tested and compared with a chemical control (oxadiazon) and a non-mulched/non-treated control. Two levels of overhead irrigation were evaluated: 1) daily irrigation to container capacity (well watered) and 2) daily irrigation to 30% of container capacity (water stressed). Two weed management regimes were used: 1) hand weeding three times during the growing season and 2) no weeding until the end of the growing season. Plants were potted in 3-L containers and arranged in a split–split plot design in an experimental nursery. Ornamental shoot dry weight was measured at the end of the growing season. Weed shoot dry weight per container was recorded after each hand weeding. Water content per pot (as a percentage of water-holding capacity) was measured by weighing containers every 2 hours during the day. Substrate temperature was measured in the warmest period of the day. Mulches limited weed growth to the same extent as the chemical control. In 2008, mulched plants resulted in a higher shoot dry weight than non-treated and non-mulched plants, while in the second year, no differences were observed. The black color of the 3-L containers was probably the main factor driving substrate temperature increase, indicating mulching materials did not affect substrate temperatures. In both experiments, container water content was unaffected by mulching materials. Results seem to demonstrate that transpiration is the main component of water loss from container-grown giant arborvitae plants.
Crizotinib Versus Chemotherapy on ALK-positive NSCLC: A Systematic Review of Efficacy and Safety
Authors: Wang Mingxia , Wang Guanqi , Ma Haiyan , Shan Baoen
Published: December 2018

Introduction: Crizotinib was approved to treat anaplastic lymphoma kinase (ALK)-
positive non-small cell lung cancer (NSCLC) by the Food and Drug Administration in 2011.We
conducted a systematic review of clinical trials and retrospective studies to compare the efficacy and
safety of crizotinib with chemotherapy.

Methods: We searched electronic databases from inception to Dec. 2016. Clinical trials and retrospective
studies regarding crizotinib and crizotinib versus chemotherapy in treatment of NSCLC
were eligible. The primary outcomes were the objective response rate (ORR) and disease control rate
(DCR).

Results:

Nine studies (five clinical trials and four retrospective studies) including 729 patients met
the inclusion criteria. Crizotinib treatment revealed 1-year OS of 77.1% and PFS of 9.17 months.
And crizotinib had a better performance than chemotherapy in ORR (OR: 4.97, 95%CI: 3.16 to 7.83,
P<0.00001, I2=35%). DCR revealed superiority with crizotinib than chemotherapy (OR: 3.42, 95%
CI: 2.33 to 5.01, P<0.00001, I2=0%). PR (partial response) were significant superior to that of chemotherapy
through direct systematic review. No statistically significant difference in CR (complete
response) was found between crizotinib-treated group and chemotherapy-treated group. Regarding
SD (stable disease), chemotherapy-treated group had a better performance than crizotinib-treated
group. Common adverse events associated with crizotinib were visual disorder, gastrointestinal side
effects, and elevated liver aminotransferase levels, whereas common adverse events with chemotherapy
were fatigue, nausea, and hematologic toxicity.

This systematic review revealed improved objective response rate and increased disease
control rate in crizotinib group comparing with chemotherapy group. Crizotinib treatment
would be a favorable treatment option for patients with ALK-positive NSCLC. ALK inhibitors may
have future potential applications in other cancers driven by ALK or c-MET gene mutations.
Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids
Authors: de Carvalho Priscila Goes Camargo , Ribeiro Jhonatan Macedo , Garbin Renata Perugini Biasi , Nakazato Gerson , Yamada Ogatta Sueli Fumie , de Fátima Ângelo , de Lima Ferreira Bispo Marcelle , Macedo Fernando
Published: December 2018

Background:

Thiohydantoins are an important class of heterocyclic compounds in drug discovery since they are related to a wide range of biological properties including antimicrobial activity.

Objective:

The objective of this study was to synthesize a series of thiohydantoins derived from Laminoacids and to evaluated their inhibitory effect on the growth of Gram-negative and Grampositive bacteria.

Methods:

All title compounds were synthetized by reaction of L-amino acids with thiourea or ammonium thiocyanate. Their antimicrobial activities were evaluated against bacterial strains by broth microdilution assays. The time-kill kinetics, the antibiofilm activity and the cytotoxicity to mammalian cells were determined for the compound that exhibited the best antimicrobial profile (1b).

Results:

Eleven thiohydantoins were readily obtained in good yields (52-95%). In general, thiohydantoins were more effective against Gram-positive bacteria. Compound 1b (derived from Lalanine) showed the best antibacterial activity against Staphylococcus epidermis ATCC 12228 and S. aureus BEC 9393 with MIC values of 940 and 1921 µM, respectively. The time-kill kinetics demonstrated time-dependent bactericidal effect in both strains for this derivative. Besides, 1b also exhibited antibacterial activity against biofilms of S. epidermidis ATCC 12228, leading to a 40% reduction in their metabolic activity compared to the untreated control. No cytotoxicity of 1b to mammalian cells was observed at MIC values.

Conclusion:

The data reported herein indicate relevant antimicrobial activity of thiohydantoins derived from L-aminoacid, mainly 1b, as potential pharmacophore to guide further chemical modification aiming at the search for new and improved antimicrobial agents.
Major Depressive Disorder in Neuroimaging: What is Beyond Fronto-limbic Model?
Authors: Lai Chien-Han
Published: December 2018

Background:

The major depressive disorder (MDD) is a chronic illness with major manifestations in cognitive, social and occupational functions. The pathophysiological model is an intrigue issue for scientists to understand the origin of MDD.

Objective:

In the beginning, the cortico-limbic-striato-pallidal-thalamic model has been proposed to link the clinical symptoms with the abnormalities in brain structure and function. However, the model is still evolving due to recent advances in the neuroimaging techniques, especially for functional magnetic resonance imaging (fMRI). The recent findings in the fMRI studies in MDD showed the importance of fronto-limbic model for the modulations between cognitive function and primitive and negative emotions.

Method:

This review will focus on the literature of fMRI studies in MDD with findings not in the fronto-limbic structures.

Results:

Additional regions beyond the fronto-limbic model have been observed in some literature of MDD. Some regions in the parietal, temporal and occipital lobes have been shown with the alterations in gray matter, white matter and brain function. The importance of sensory detection, visuospatial function, language reception, motor response and emotional memories in these regions might provide the clues to understand the cognitive misinterpretations related to altered reception of outside information, behavioral responses related to biased cognition and emotional memories and clinical symptoms related to the significant alterations of interactions between different brain regions.

Conclusion:

Future studies to establish a more comprehensive model for MDD will be warranted, especially for the model beyond the fronto-limbic structures.
A Scoping Review of Joint Protection Programs for People with Hand Arthritis
Authors: Bobos Pavlos , Nazari Goris , Lalone Emily A , Ferreira Louis , Grewal Ruby , MacDermid Joy C
Published: December 2018

Background:

Joint Protection (JP) can be enhanced by incorporating recent evidence and innovations in collaboration with people with hand arthritis to be salient, useful and effectively implemented.

Objective:

The purpose of this study is to map the current research on JP principles and guide future research on JP programs for the management of hand arthritis.

Methods:

A search was performed in 4 databases (PubMed, EMBASE, Google SCHOLAR, CINHAL) from January 1990 to February 2017. A Grey literature was also conducted through the Google web search engine. A combination of search terms was used such as hand osteoarthritis, rheumatoid arthritis, joint protection and/or self-management strategies.

Results:

Our search found 8,788 citations in which 231 articles were deemed relevant and after duplication 111 articles were retrieved for a full-text review. In total, 40 articles were eligible for data extraction. The majority of the articles were randomized controlled trials (RCTs), systematic reviews and overviews of reviews that investigated joint protection for hand arthritis. Joint protection was tested mostly in rheumatoid arthritis (RA) population and to a lesser extent on hand osteoarthritis and was provided mainly by an occupational therapist.

Conclusion:

This review synthesized and critically examined the scope of JP for the management of hand arthritis and found that RCTs, systematic reviews and overviews of reviews constituted two-thirds of the current body of literature. Furthermore, it identified a lack of clarity regarding the specific elements of joint protection programs used in clinical studies.
Role of Biplane Double Supported Screw Fixation For Fracture Neck Femur In Elderly Population: A Prospective Study
Authors: Kalia Anoop , Singh Jagdeep , Ali Nasir
Published: December 2018

Introduction:

The treatment of fracture neck femur varies according to the age of patient, the displacement of fracture fragments and the duration of the fracture. Various treatment options available for elderly are screw fixation, hemiarthroplasty and total hip arthroplasty.

Materials and Methods:

This is a prospective study done at authors institutes between January 2014- December 2016. 30 patients aged more than 50 years who sustained fracture neck femur were included in the study. 3 patients were lost to follow up and 2 patients died due to medical comorbidities. Out of the 25 remaining patients, 17 were males and 8 were females and they were operated by the biplane double supported screw fixation method (BDSF TECHNIQUE) and were followed up for a period of two years. The final Harris Hip Score at the last follow up was calculated.

Results:

Out of the 25 patients, the union was achieved in all the patients. The mean duration of union was 10 weeks. 1 patient had progressive femoral head resorption due to chondrolysis resulting in antalgic gait and unbearable pain and underwent total hip arthroplasty. The mean harris hip score was 81.2

Conclusion:

In elderly patients with osteoporosis and in those patients who can not afford arthroplasty or in those patients where arthroplasty is contraindicated, BDSF method is an alternate method for fixing fracture neck femur.
A Case Report: Custom Made Porous Titanium Implants in Revision: A New Option for Complex Issues
Authors: Burastero Giorgio , Cavagnaro Luca , Chiarlone Francesco , Innocenti Bernardo , Felli Lamberto
Published: December 2018

Background:

Bone loss management is considered one of the most difficult challenges for orthopaedic surgeon. In massive bone defects, few surgical options are available and they do not offer a reliable or optimal solution for knee reconstruction.

Objective:

The aim of this paper is to present and justify a new custom-made approach for complex metadiaphyseal bone defects management in knee revision surgery.

Methods:

We report a case of a 66-year-old woman who underwent a staged left total knee arthroplasty revision for infection with Anderson Orthopaedic Research Institute classification III uncontained femoral and tibial metadiaphyseal bone defects following five prior surgeries. Along with a case discussion, we describe clinical and radiological outcomes of 3 similar patients treated with this new custom-made device.

Results:

To manage these problems, we developed new, custom porous titanium devices for both femoral and tibial reconstruction tailored to a patient’s specific bone loss. Since, 2014, we treated four cases using custom-made porous titanium cones and we had optimal clinical and radiological results, with no instances of loosening, component migration, or mismatches between preoperative planning and intraoperative findings.

Conclusion:

In extremely selected cases, this new device can be considered a possible and viable surgical step between “off the shelf” reconstruction implants and knee substitution with a tumor megaprosthesis.
Digital Competencies and Attitudes Toward Digital Adherence Solutions Among Elderly Patients Treated With Novel Anticoagulants: Qualitative Study (Preprint)
Authors: Herrmann Maximilian , Boehme Philip , Hansen Arne , Jansson Katharina , Rebacz Patrick , Ehlers Jan P , Mondritzki Thomas , Truebel Hubert
Published: December 2018

BACKGROUND

Nonadherence to medication is a driver of morbidity and mortality, and complex medication regimens in patients with chronic diseases foster the problem. Digital technology might help, but despite numerous solutions being developed, none are currently widely used, and acceptance rates remain low, especially among the elderly.

OBJECTIVE

This study aimed to better understand and operationalize how new digital solutions can be evaluated. Particularly, the goal was to identify factors that help digital approaches targeting adherence to become more widely accepted.

METHODS

A qualitative study using a conceptual grounded theory approach was conducted. We included patients aged 65 years and older who routinely took new oral anticoagulants. To generate theses about the digital competencies of the target group with daily medication intake, face-to-face interviews were conducted, recorded, and anonymized. After coding the interviews, categories were generated, discussed, and combined with several theses until saturation of the statements was reached.

RESULTS

The methodological approach led to the finding that after interviews in 20 of 77 potentially available patients, a saturation of statements was reached. The average patient’s age was 75 years, and 50% (10/20) of the subjects were female. The data identified five main coding categories—Diseases and medicine, Technology, Autonomy, Patient narrative, and Attitude toward technologies—each including positive and negative subcategories. Main categories and subcategories were summarized as Adherence Radar, which can be considered as a framework to assess the potential of adherence solutions in the process of prototyping and can be applied to all adherence tools in a holistic manner.

CONCLUSIONS

The Adherence Radar can be used to increase the acceptance rate of digital solutions targeting adherence. For a patient-centric design, an app should be adapted to the individual patient’s needs. According to our results, this application should be based on gender and educational background as well as the individual physician-patient relationship. If used in a proper, individualized manner, digital adherence solutions could become a new cornerstone for the treatment of chronically ill individuals.
Impact of an integral assistance model between primary care and cardiology on the management of patients with ischemic heart disease or atrial fibrillation
Authors: Freixa-Pamias Román , Gràcia Pedro Blanch , Rodríguez Latre Maria Lluïsa , Basile Luca , Chamero Pilar Sanchez , Martínez-Rubio Antoni , Lupón Josep , trabajo de Atención Integrada Cardiología-Atención Primaria Grupo de
Published: December 2018

Aim:
To analyze the impact of implementing a program integrating cardiology and primary care in clinical practice.
Methods:
In the integrated care model, every cardiologist was assigned to each primary care center.
Results & conclusion:
The implementation of the new care model was associated with a significant reduction of 31.2% in requests of first visits. In addition, the delay to the cardiologist consultation significantly decreased by 54.5% for the first visits, and by 57.1% for the follow-up visits. The proportion of patients that achieved recommended low density lipoprotein-cholesterol goals significantly increased from 20.8 to 29.6%. The proportion of patients submitted to anticoagulant therapy significantly increased from 69.3 to 74.2%, as well as the proportion of patients taking direct oral anticoagulants (from 7.9 to 28.4%).
The influence of rs53576 and rs2254298 oxytocin receptor gene polymorphisms on plasma oxytocin levels and measures of empathy
Authors: Basic Jelena , Milosevic Vuk , Stankovic Milos , Jevtovic-Stoimenov Tatjana , Cvetkovic Tatjana , Despotovic Milena , Pavlovic Dusica
Published: December 2018

Oxytocin achieves its effects after binding the oxytocin receptor (OXTR). Oxytocin plays an important role in empathy. The aim of this study was to examine the influence of two single nucleotide polymorphisms (SNPs) of the OXTR gene (rs53576 and rs2254298) on empathy measures and plasma oxytocin levels. Seventy-four university students were screened for the OXTR rs53576 and rs2254298 SNPs using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The level of oxytocin in the plasma was measured by the enzyme linked immunosorbent assay (ELISA). All subjects were assessed with the empathy quotient (EQ) questionnaire and Reading the Mind in the Eyes Test (RMET). Subjects carrying the rs53576 GG genotype had a higher EQ score, compared to GA/AA genotype carriers. By gender analysis, significance was reached only in females. Considering the influence of both examined polymorphisms on empathy, participants with the GGGG diplotype had a higher EQ in comparison with GAGG/AAGG carriers. These hormone effects were not correlated with plasma oxytocin levels. This is the first study implying that higher empathy in rs53576 GG genotype carriers may not depend on plasma oxytocin levels, but possibly on the number and function of OXTRs in the brain.
Hybrid treatment of thoracoabdominal aortic aneurysm: Case series and review of the literature
Authors: Zlatanovic Petar , Koncar Igor , Markovic Miroslav , Trailovic Ranko , Cvetic Vladimir , Davidovic Lazar
Published: December 2018

Background/Aim. Open thoracoabdominal aortic aneurysm (ThAAAs) repair is a challenging mission. Total endovascular approach is performed at selected institutions in developing countries, however these are not generalizable. Hybrid procedures offer an alternative approach. The aim of this study was to present our results of the ThAAA hybrid treatment and a literature review. Methods. This is a retrospective study of all patients that underwent the hybrid ThAAA repair at our institution between January 2011 and January 2018. Hybrid ThAAA repair was done as a twostaged procedure ? open visceral debranching followed by stent-graft placement (TEVAR). The following data from eligible studies were extracted and analyzed: first author, publication year, patient sample, 30-day/in-hospital mortality, permanent paraplegia rate, presence of endoleaks and graft patency after the follow-up period, overall survival and mean follow-up period. Results. Seven patients underwent the hybrid ThAAA repair at our institution. Neither intraoperative death nor technical failure due to TEVAR was observed. Mean follow-up rate after discharge was 51.71 months [95% confidence interval (CI): 14.67?88.74 months]. At the time of the follow-up, all bypasses were patent and no prosthesis migration was documented. After one year, a case of type Ib endoleak was identified and treated successfully. Twenty-five studies were eligible for the literature review. Primary technical success was 91.69% (95% CI: 85.34?97.24%). Mean percentage of permanent paraplegia was 5.27% (95% CI: 3.55?7.01%). Visceral graft patency during the mean follow-up of 27.54 months (95% CI: 17.41?37.66 months) was 94.5% (95% CI: 92.5?96.5%). Mean pooled percentage rate of overall endoleaks during the follow-up period was 16.72% (95% CI: 11.15?22.29%). Analysis revealed 15.32% (95% CI: 11.04?19.61%) of 30- day/in-hospital mortality and 65.98% (95% CI: 58.15? 73.81%) of overall survival after the follow-up period. Conclusion. Although thought as less invasive, the hybrid ThAAA repair is still associated with a considerable morbidity and mortality.
Studi Adsorpsi Ion Ni(II) Menggunakan Crosslink Kitosan Tripolifosfat
Authors: Kurniasih Mardiyah , Riyani Kapti , Setyaningtyas Tien , Sufyana Ira
Published: December 2018

Kitosan adalah polisakarida alami. Kitosan memiliki gugus amino dan hidroksi sehingga memungkinkan untuk memodifikasi kitosan secara kimia untuk memperluas aplikasi. Modifikasi kitosan dengan agen crosslinker dapat meningkatkan kapasitas adsorpsinya. Tripolifosfat merupakan agen crosslinker yang non toksik. Kitosan bersifat polikationik dan tripolifosfat bersifat polianionik sehingga dapat berinteraksi membentuk crosslink kitosan tripolifosfat. Tujuan dari penelitian ini yaitu mensintesis crosslink kitosan tripolifosfat dan studi adsorpsi ion Ni(II). Kitosan diperoleh dari deasetilasi kitin. Crosslink kitosan tripolifosfat disintesis dengan mereaksikan larutan kitosan dan larutan sodium tripolifosfat pH 3. Studi adsorpsi ion Ni(II) menggunakan crosslink kitosan tripolifosfat dilakukan pada variasi pH, waktu kontak dan perbandingan adsorben dan adsorbat. Variasi perbandingan adsorben dan adsorbat pada larutan Ni(II) digunakan untuk kajian adsorpsi isotermal. Hasil analisis menggunakan FTIR menunjukkan serapan pada daerah bilangan gelombang 1535,34 cm-1 yang menandakan adanya interaksi ion ammonium dan ion fosfat. Crosslink kitosan tripolifosfat dapat menurunkan ion Ni(II) sebanyak 50,536 % dengan kapasitas adsorpsi 8,205 mg/g dan mengikuti pola adsorpsi isotermal Freundlich.
Use of TiO2 Powder and Activated Carbon as Catalytic Ceramic Filling Material to Reduce Hazardous Pollutants on Gasoline Engine
Authors: Setiyono Dwi Rahmad , Widjanarko Dwi
Published: December 2018

The purpose of this study was, 1) to examine the effect of the mixture composition between ceramics, TiO2, and activated carbon on catalytic converters on vehicle exhaust emissions, 2) test the composition of the mixture between ceramic, TiO2, and activated carbon in catalytic converters that produce the most exhaust emissions low. This study uses an experimental method with descriptive statistics. The independent variable is catalytic converter with a variety of ceramic material composition with a mixture of TiO2 and activated carbon. Control variables are the composition of the mixture, catalytic converter porosity control, standard exhaust without catalytic converter, engine speed used at stationary speed, and duration of testing time. Dependent variables are vehicle exhaust emissions CO and HC. The results of this study are, 1) The use of ceramic materials mixed with TiO2 and activated carbon in catalytic converters can reduce CO and HC content in gasoline-powered vehicles. 2) The best reduction is in the composition of 50% ceramic material, 25% TiO2, and 25% activated carbon, which is able to reduce CO content from 4.19% to 1.44% and HC gas. Suggestions from this study are, gasoline-powered vehicles can use catalytic converters made from Ceramic with a mixture of TiO2, and activated carbon with a composition of 50% ceramic material, 25% TiO2, and 25% activated carbon.
Adsorpsi Methyl Violet oleh Karbon Aktif dari Limbah Tempurung Kelapa dengan Aktivator ZnCl2 Menggunakan Pemanasan Gelombang Mikro
Authors: Astuti Widi , Dwi Handayani Anggelita , Wulandari Diah Ayu
Published: December 2018

Synthesis of activated carbon from coconut shell waste with ZnCl2 activation using microwave heating have been carried out. Coconut shell consists of 36.51% lignin, 33.61% cellulose and 19.27% hemicellulose which causes it can be used as a precursor in the synthesis of activated carbon. The activated carbon was further characterized using Scanning Electron Microscope (SEM), Fourier Transform Infrared Spectrophotometer (FTIR) and NOVA Gas Sorption Analyzer-Quantachrome and used for the adsorption of methyl violet in aqueous solution with variation of pH, contact time and concentration of solution. The result showed that the pore of activated carbon was larger than that of the char. The optimum adsorption occurred at pH 3 and the equilibrium time was reached after 180 minutes. The Langmuir equilibrium model was more appropriate than the Freundlich equilibrium model. While the kinetics model analyzed using pseudo first order, pseudo second order, internal diffusion and external diffusion indicated that the pseudo second order was most suitable for the adsorption of methyl violet by coconut shell activated carbon.
Perengkahan n-Butana Menggunakan Katalis Nanopartikel Zeolit Alam Klaten
Authors: Kurniawan Teguh , Muraza Oki
Published: December 2018

Increasing demand on olefins, high energy consumption of thermal cracking and oil depletion are the driving force to find new process to produce olefins. Catalytic cracking of n-butane is promising route to produce olefins. In this paper, we synthesized nanoparticle from natural zeolites by ball milling-recrystallization method and studied the effect of acid dealumination over the nanozeolites on the catalytic properties. Particle size was evaluated visually by using scanning electron microscope.  X-Ray Diffraction analysis was performed to study zeolites phase and its crystallinity. Acid dealumination effect over nanosized mordenite on the acidity were evaluated by ammonia TPD and pyridine FTIR. Textural properties of zeolites were characterized by nitrogen physisorption at -196 oC. The catalysts were tested in a fixed bed reactor for n-butane cracking to olefins product. Various temperature conditions were applied ranging from 350 oC to 650 oC for n-butane cracking in a fixed bed reactor. Conversions of n-butane were 15% and 90% at 350 oC and 650 oC, respectively. Selectivity to olefins was increase from 1% at 350 oC to 47% at 650 oC.
El perfil pluridireccional del receptor de la denominada literatura infantil y juvenil: hacia una delimitación conceptual en el ámbito de su traducción
Authors: Mendoza García Inma
Published: December 2018

Desde una perspectiva multidisciplinar, en este trabajo se realiza una revisión crítica del mapa conceptual precedente en torno al receptor de lo que tradicionalmente se conoce como literatura infantil y juvenil (LIJ) y se reflexiona sobre el impacto que sus diferentes perfiles pueden ejercer en su traducción. A partir de estas consideraciones previas, se propone un nuevo modelo de clasificación de LIJ que, aplicado al ámbito de la Traductología, permitirá obtener información más precisa sobre los verdaderos intereses y expectativas de sus receptores en torno a la dicotomía domesticación y extranjerización, así como sobre el comportamiento traductor y la tendencia editorial a este respecto.
Electro-gene therapy followed by intratumoral injection of pcDNA3.1-p27Kip1 wild type in human tongue base cancer cells SP-C3 xenograft
Authors: Supriatno S. , Sasmita Inne Suherna
Published: December 2018

Human tongue base cancers are characterized by a high degree of local invasion and metastasis to the regional lymph nodes and included a disease with difficult treatment. A novel method for high-efficiency and region-controlled in vivo gene transfer was developed by combining electro-gene therapy and plasmid (pcDNA). The aims of the study were to examine the efficiency of transfection of p27Kip1 gene by electro-gene therapy and to evaluate p27Kip1 gene therapy in Supri’s clone-3 (SP-C3) xenografts using pcDNA3.1-p27Kip1 wild-type (wt) and pcDNA3.1 empty vector (neo) with electro-gene therapy. To investigate gene transfer method, the enhanced green fluorescence protein (EGFP) gene was transfected into xenografts by electro-gene therapy. The efficiency of p27Kip1 gene transfection at protein level was confirmed by Western blotting. To estimate the reduction in tumour size in Wistar Balb/c mice after electro-gene therapy with p27Kip1 wt gene was examined by tumorigenesis assay. To evaluate the induction of apoptosis was carried out by colourimetric assay. The result, the growth of tumours was markedly suppressed by p27Kip1 wt gene transfection. Up-regulation of p27Kip1 protein was detected in pcDNA3.1-p27Kip1 wt. Apoptosis induction through the activity of caspase -3 and -9 was significantly increased in p27Kip1 wt-transfected tumours. These results suggest that it is possible to transfer p27Kip1 wt into tongue base cancer cell xenografts using electro-gene therapy. p27Kip1 wt had a high-potential to suppress the growth of tumours. Conclusion, electro-gene therapy followed by intratumoral injection of pcDNA3.1-p27Kip1 wt had a high-potential to suppress the growth of a human tongue base cancer cell xenograft.
The effect of giving NaOCL 2.5% and H2O2% solution on the initial setting Mineral Trioxide Aggregate (MTA)
Authors: Wardhani Saraswati Dian , Usman Munyati , Kamizar K.
Published: December 2018

Today, Mineral Trioxide Aggregate (MTA) is one of the most commonly-used materials to overcome problems in dental pulp as well as periodontal tissue. This substance received its permission from the American Food and Drug Administration (FDA) in 1998 and has been patented as a Portland type I.ASTM C150 cement-base material. However, MTA still has its flaws, such as: its granule form, requirement for moist condition, mass losing during hydration (high solubility), and particularly its time-consuming setting duration (45’-165’). Some researches attempt the usage of regular accelerator together with Portland cement, yet there’s still no certainty of the best concentration that can be used to gain optimal result. This research conducted a time test of the initial setting of MTA that was mixed with the strong-oxidation antimicrobial solutions, they are NaOCl 2.5% dan H2O2 3%. The instrument used was the Gillmore needle. Data analysis used one-way ANOVA and Mann Whitney significance test (p<0,05). The result of the research showed that the mixing of NaOCl 2.5% with MTA the initial setting was ± 11 minutes and the mixing of NaOCl 2.5% with MTA the initial setting was ± 5 minute, it compared with the initial setting of original MTA which was the initial setting ± 50 minutes.
Comparison of bond strength between self-adhered and conventional composites
Authors: Putra Adria Permana , Karlina Elin , Febrida Renny
Published: December 2018

Bond strength towards dentine is a critical factor for composite restoration success. The purpose of this research was to obtain data on self-adhered composite bond strength to tooth dentine. This research was an experimental laboratory research that used 10 third molar teeth as samples. The teeth were prepared by thinning its mesial part until it reaches dentine layer. The sample was divided into two groups, each consisting of 5 teeth. In group I was applied self-adhered composite with Fusio® Liquid Dentine brand, whereas group II was applied conventional composite with Ivoclar Te-Econom Flow®. The applied composite had a cylindrical shape with 6 mm diameter. The sample was then placed on the test arm. The shear bond strength test method then conducted on Universal Testing Machine (UTM). Obtained data was tested using Two-tails Independent t-Test (α = 0,05). The results showed the average of self-adhered composite bond strength to dentine is 1,8878 ± 0,2859 MPa and conventional composite for 4,43552 ± 0,49472 MPa. The data showed that the self-adhered composite bond strength to dentine is smaller than conventional composite. From this research can be concluded that there was bond strength difference between the self-adhered composite with conventional composites towards the tooth dentine.
Réplica
Authors: Ibarra Antonio
Published: December 2018

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Assessment of Factors Affecting the Foreign Investment Attraction in Iran
Authors: Mohammadi Fereshteh Molla
Published: December 2018

Foreign investment is a critical development strategy. The aim of the study was to investigate the factors affecting the attraction of foreign investment in Iran. The statistical population included foreign investment companies covered by the Foreign Investment Promotion and Protection Act and some experts from investment licensing executive agencies in Tehran province. A total of 400 subjects were enrolled in 2014-2017. The data analysis was performed using Kolmogorov-Smirnov test. All foreign investment companies covered by the investment promotion and protection law were studied by sampling. In addition, a non-random sampling method was used at the experts’ level in the operating systems and executive organisations. In the present research, the Cochran formula was used to determine the sample size being 400 subjects. As a result, 550 questionnaires were distributed and completed; finally, 400 questionnaires were received and analysed in a correct and complete manner. Within the framework of the research, the parametric test (t-test) and linear regression were used for data analysis and the hypotheses due to normal distribution. After analysing the data collected from results of the respondents’ responses and based on mathematical and statistical models, the most important factors affecting foreign investment attraction were the economic factor (p<0.001) followed by the social factor (p=0.002), the administrative bureaucracy (p=0.003), cultural factor (p=0.021) and the agent of the state (p=0.031), all of which exhibited a significant relationship. Based on the results, the economic and cultural factors were the most effective parameters affecting foreign investment.
Forecast of Carbon Dioxide Emissions from Energy Consumption in Industry Sectors in Thailand
Authors: Sutthichaimethee Pruethsan , Ariyasajjakorn Danupon
Published: December 2018

The aim of this research is to forecast CO2emissions from consumption of energy in Industry sectors in Thailand. To study, input-output tables based on Thailand for the years 2000 to 2015 are deployed to estimate CO2emissions, population growth and GDP growth. Moreover, those are also used to anticipate the energy consumption for fifteen years and thirty years ahead. The ARIMAX Model is applied to two sub-models, and the result indicates that Thailand will have 14.3541 % on average higher in CO2emissions in a fifteen-year period (2016-2030), and 31.1536 % in a thirty-year period (2016-2045). This study hopes to be useful in shaping future national policies and more effective planning. The researcher uses a statistical model called the ARIMAX Model, which is a stationary data model, and is a model that eliminates the problems of autocorrelations, heteroskedasticity, and multicollinearity. Thus, the forecasts will be made with minor error.
Determination of Tungsten Inert Gas Welding Input Parameters to Attain Maximum Tensile Strength of 316L Austenitic Stainless Steel
Authors: Moi Subhas Chandra , Pal Pradip Kumar , Bandyopadhyay Asish , Rudrapati Ramesh
Published: December 2018

Weld quality mainly depends on the weld bead geometry and mechanical-metallurgical characteristics of the welded joint which has a direct relationship with the type of welding process being used and its input process parameters i.e. welding current, arc voltage, travel speed etc. In the present study, determination of tungsten inert gas (TIG) welding input parameters for achieving maximum tensile strength of 316L austenitic stainless steel is investigated. Box-Behnken design of response surface methodology has been employed to formulate the experimental plan to identify the effect of process parameters on tensile strength. Square butt joint configuration has been made using three factors - three levels of welding input parameters. Joint strength has been evaluated by notch tensile strength (NTS) and Unnotch tensile strength (UTS) method and correlated with microstructure and micro hardness of the weld. The results indicate that gas flow rate has greater influence on both NTS and UTS followed by welding current.
â€œCherchons la femme!â€: The Dynamics of Gender Relations and Emergent Complexity in Neolithic Ã‡atalhÃ¶yÃ¼k
Authors: Dederen Jean-Marie , Mokakabye Jennifer
Published: December 2018

Ever since the first artefacts and structures of Ã‡atalhÃ¶yÃ¼k were excavated by James Mellaart in the 1960s, researchers have debated why sedentary farmers, whose diet included domesticated plants, sheep and goat, displayed a myriad of aurochs bull and other hunting trophies inside some of their houses. Equally puzzling have been two parallel developments in the later habitation levels. On the one hand the excavators noted how the wild animal trophies gradually decreased in number and eventually faded away towards the final Neolithic occupation. On the other hand they established that the material and symbolic presence of women in this prehistoric town was growing stronger. It is proposed that these two processes were connected and that they can be elucidated in terms of the femaleâ€“male dialectic which may have generated them.
Hydration Structure of Sodium and Potassium Ions with DFT-MD
Authors: Duignan Timothy , Schenter Gregory K. , Galib Mirza , Baer Marcel D. , Wilhelm Jan , Hutter Jürg , Ben Mauro Del , Zhao Xiu Song , Mundy Christopher J.
Published: December 2018

The ability to reproduce the structure of water around the sodium and potassium ions as determined by experiment is a key test of the quality of interaction potentials due to the central importance of these ions in a wide range of important phenomena. Here, we simulate the Na+ and K+ ions in bulk water using the recently developed strongly constrained and appropriately normed (SCAN) functional and compare with experimental X-ray diffraction (XRD) and X-ray adsorption fine structure (EXAFS) measurements to demonstrate that it accurately reproduces important structural details of the hydration structure of the sodium and potassium cations. We demonstrate that it performs substantially better than the generalized gradient approximation (GGA) based dispersion corrected revised Perdew, Burke, and Ernzerhof functional (revPBE-D3) and is even better than the random phase approximation level for potassium. Both of these functionals have been demonstrated to accurately reproduce the structure of bulk water. This improved performance compared with revPBE-D3 is attributed to smaller fluctuations of the mean error of ion-water cluster binding energies utilizing a novel benchmark for testing functionals.
Dinâmica do uso e cobertura da terra no município de Miranda-MS, Pantanal Sul (Analysis of the Natural Vulnerability of the Banabuiú River Basin, with Support of Geotechnology)
Authors: Leite Vanessa Aline Wagner , Rodrigues Lidiane Perbelin , Leite Emerson Figueiredo
Published: December 2018

O município de Miranda ocupa uma extensão territorial de 5.478,82km localizados entre os paralelos 20° 29’ e 19° 39’ Sul, e meridianos 57° 01’ e 56° 11’ Oeste. Este munícipio foi escolhido como objeto de estudo desta pesquisa por contemplar áreas dos domínios Cerrado e Pantanal, além de remanescentes da Mata Atlântica, estando situado no contexto da bacia do Alto Paraguai. O objetivo deste trabalho foi analisar a dinâmica de uso e cobertura da terra do município Miranda-MS nos anos de 2006, 2011 e 2017 usando o software Spring/Inpe. Durante a pesquisa foram utilizadas imagens dos satélites Landsat 5-TM e 8-OLI, cena 226/74, que foram processadas no Spring 4.3.3. Para atenuar as diferenças existentes entre as imagens de diferentes sensores imageadores foi realizada a correção atmosférica das imagens e para ressaltar os remanescentes florestais do Pantanal, Cerrado e mata Atlântica foi aplicado o Normalized Difference Vegetation Índex (NDVI). Para classificação das imagens foi utilizado o Método híbrido de Moreira (2012) e o classificador empregado foi o Isoseg. As classes adotadas no mapeamento foram adaptadas do IBGE (2013): Cicatriz de Queimada, Remanescentes Florestais, Campo/Pasto, Corpos D’água, Área Urbana – Miranda, Agricultura Irrigada. Os resultados obtidos permitiram aferir a grande influência hidroclimática e do relevo nas mudanças no uso e cobertura da terra observadas, uma vez que anos de seca são favoráveis ao avanço da antropização de áreas naturais e sua consequente fragmentação.   A B S T R A C TThe watershed of the Banabuiú River presents a high degree of environmental degradation, caused by poor land use, low social and economic development and excel of the plan and inefficient management of its resources. As a result, the present work aimed to define the support of geotechnologies, a natural fragility and vulnerability of the basin of the Banabuiú river, through the natural susceptibility of the lands to erosive processes in order to contribute to the sustainable development of the basin. The methods used in the research development will follow the adaptation of the methodologies proposed by Crepani (1996 and 2001), who propose an evaluation of the lands according to an integrated analysis of the environment. For that, maps of geology, geomorphology, pedology, vegetation and climate were elaborated. The overlapping of rights in GIS paper generated the basin's natural vulnerability map. It was observed that 34.638% of the basin area is characterized as the average or vulnerable and in 63.38% as moderately stable. It is also possible to observe the high values of the reserve of the perennial rivers and in the margins of the main reservoirs, which represent risks to the river basin.Keywords: susceptibility, water resources, planning and management.
Buchbesprechungen
Authors: Orth Ernst Wolfgang , Witte Egbert , Hand Annika , Cusinato Guido , Balle Johannes , Keiling Tobias
Published: December 2018

"Ernst Cassirer: Ausgewählter wissenschaftlicher Briefwechsel; Martin Heidegger: Seminare (Übungen) 1937/38 und 1941/42; Gottfried Boehm, Horst Bredekamp (Hg.): Ikonologie der
Gegenwart / Antje Kapust, Bernhard Waldenfels (Hg.): Kunst. Bild.
Wahrnehmung. Blick. Merleau-Ponty zum Hundertsten; Joachim Fischer: Philosophische Anthropologie. Eine Denkrichtung des 20. Jahrhunderts; Matthias Schloßberger: Die Erfahrung des Anderen. Gefühle im menschlichen Miteinander; Andrea Sebastiano Staiti: Geistigkeit, Leben und geschichtliche Welt in der Transzendentalphänomenologie Husserls"
Post Tsunami: Marine Protected Areas (MPA) Zonation Structure of Pulo Aceh, Indonesia
Authors: Rusdi Muhammad , Khalil Munawar , Zulfikar Zulfikar
Published: December 2018

Penelitian ini bertujuan untuk menganalisis pembentukan kawasan perlindungan laut (Marine Protected Areas/MPA) di Pulo Aceh, Indonesia, dengan menggunakan input dari analisis Sistem Informasi Geografis. Langkah-langkah pengelolaan adalah diperlukan untuk memastikan bahwa sumber daya laut dapat hidup dan ekosistem dapat dilestarikan. Fokus penelitian ini adalah untuk menunjuk daerah-daerah tertentu sebagai daerah perlindungan laut (DPL). Pulo Aceh meliputi 24,961.9 hektar yang terdiri dari habitat daratan dan habitat lautan yang terpilih sebagai kawasan MPA. Zonasi di kawasan konservasi laut didasarkan pada data ekologi dan data ekologi konservasi, sosial ekonomi dan budaya masyarakat setempat. Zona utama yang telah ditetapkan dan dipetakan dalam kawasan konservasi, yaitu zona inti (94,14 ha atau 0,38 %), zona pemanfaatan (15,144.86 ha atau 60,67 %) dan zona penyangga (1,038.77 ha atau 4,16 %). Zona inti sangat dilarang dari kegiatan pengambilan hasil laut, pariwisata dan ekonomi, sementara kegiatan penelitian dan konservasi dapat diperbolehkan. Zona pemanfaatan dibagi menjadi area untuk pariwisata, penggunaan tradisional, penggunaan pelagis, penelitian dan pelatihan. Akomodasi permanen untuk kegiatan pariwisata atau pengambilan sumber daya alam diperbolehkan melalui pelaksanaan proses penilaian dampak lingkungan terlebih dahulu. Kegiatan di zona penyangga adalah sangat terbatas dan dikendalikan sepenuhnya hanya untuk kegiatan pengambilan hasil laut.
Karakter Agronomi Beberapa Varietas Sorgum pada Lahan Marginal di Aceh Utara
Authors: D Elvira S , Yusuf Muhamad , Maiyuslina Maiyuslina
Published: December 2018

Penelitian dilaksanakan di Kebun Percobaan Fakultas Pertanian Universitas Malikussaleh dengan ketinggian tempat 18 m dpl dari bulan Nopember 2013 sampai Pebruari 2014. Penelitian menggunakan rancangan acak kelompok non faktorial dengan 3 ulangan. Data menunjukkan bahwa tinggi tanaman dan diameter batang setiap varietas sorgum tidak berbeda nyata pada 30 HST. Hasil yang lebih variatif didapati untuk tinggi tanaman dan diameter batang pada 60 dan 90 HST. Tinggi tanaman pada 60 HST lebih didominasi oleh varietas Numbu yang tidak berbeda nyata dengan varietas UPCA dan CTY-33.Selanjutnya diikuti oleh varietas Kawali yang tidak berbeda nyata dengan varietas. Berat 1000 biji sorgum tertinggi didapati pada varietas CTY-33 yang tidak berbeda nyata dengen varietas Numbu dan UPCA. Selanjutnya diikuti oleh varietas Mandau dan Kawali. Sedangkan untuk berat berangkasan basah juga didominasi oleh varietas CTY-33 yang tidak berbeda nyata dengan varietas UPCA. Diikuti oleh varietas Numbu, Kawali dan Mandau.  Berat berangkasan kering tertinggi diperoleh dari varietas CTY-33 dan diikuti oleh varietas UPCA, Kawali, Numbu dan Mandau. Secara umum, varietas CTY-33 unggul dari semua parameter pengamatan.
Treatment Limbah Industri Pulp dengan Metode Filtrasi untuk Menjaga Kualitas Air DAS Ciujung
Authors: Ruhiat Yayat , Akbar Halim
Published: December 2018

Minimalisasi limbah merupakan implementasi untuk mengurangi jumlah dan tingkat cemaran limbah yang dihasilkan dari suatu proses produksi dengan cara pengurangan, pemanfaatan dan pengolahan limbah. Pada penelitian ini, treatment terhadap limbah pulp dilakukan dengan metode filtrasi. Dalam memberikan perlakuan terhadap limbah pulp melalui metode filtrasi dilakukan dalam dua tahapan. Pertama, mengkaji dan mengoptimalkan sisa hasil produksi. Kedua, mendesain filter yang berfungsi untuk meminimalisasi kadar limbah sebelum dibuang ke sungai, sehingga kualitas air sungai tetap terjaga. Hasil pengukuran konsentrasi pencemar setelah dilakukan filtrasi, terjadi pula penurunan konsentrasi di beberapa titik sampling. Konsentrasi pencemar dipengaruhi oleh debit limbah yang dibuang dari industri ke sungai. Dalam menganalisis konsentrasi pencemar di Daerah Aliran Sungai (DAS) Ciujung menggunakan nilai kondisi awal (initial conditions) dan nilai kondisi batas (boundary conditions) sebagai input model.