bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic breakpoint-specific monitoring of measurable residual disease in pediatric non-standard-risk acute myeloid leukemia
Authors: Maurer-Granofszky Margarita , Kohrer Stefan , Fischer Susanna , Schumich Angela , Nebral Karin , Larghero Patrizia , Meyer Claus , Mecklenbrauker Astrid , Muhlegger Nora , Marschalek Rolf , Haas Oskar A. , Panzer-Grumayer Renate , Dworzak Michael N.
Published: June 2023

Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease making standardized measurable residual disease (MRD) assessment challenging. Currently, patient-specific DNA-based assays are only rarely applied for MRD assessment in pediatric AML. We tested whether quantification of genomic breakpoint-specific sequences via quantitative polymerase chain reaction (gDNA-PCR) provides a reliable means of MRD quantification in children with non-standardrisk AML and compared its results to those obtained with state-of-the-art ten-color flow cytometry (FCM). Breakpointspecific gDNA-PCR assays were established according to Euro-MRD consortium guidelines. FCM-MRD assessment was performed according to the European Leukemia Network guidelines with adaptations for pediatric AML. Of 77 consecutively recruited non-standard-risk pediatric AML cases, 49 (64%) carried a chromosomal translocation potentially suitable for MRD quantification. Genomic breakpoint analysis returned a specific DNA sequence in 100% (41/41) of the cases submitted for investigation. MRD levels were evaluated using gDNA-PCR in 243 follow-up samples from 36 patients, achieving a quantitative range of at least 10-4 in 231/243 (95%) of samples. Comparing gDNA-PCR with FCM-MRD data for 183 bone marrow follow-up samples at various therapy timepoints showed a high concordance of 90.2%, considering a cut-off of ≥0.1%. Both methodologies outperformed morphological assessment. We conclude that MRD monitoring by gDNA-PCR is feasible in pediatric AML with traceable genetic rearrangements and correlates well with FCM-MRD in the currently applied clinically relevant range, while being more sensitive below that. The methodology should be evaluated in larger cohorts to pave the way for clinical application.
Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia
Authors: Pagano Giulia , Botana Iria Fernandez , Wierz Marina , Roessner Philipp M. , Ioannou Nikolaos , Zhou Xiangda , Al-Hity Gheed , Borne Coralie , Gargiulo Ernesto , Gonder Susanne , Qu Bin , Stamatopoulos Basile , Ramsay Alan G. , Seiffert Martina , Largeot Anne , Moussay Etienne , Paggetti Jerome
Published: June 2023

Chronic lymphocytic leukemia (CLL) cells are highly dependent on interactions with the immunosuppressive tumor microenvironment (TME) for survival and proliferation. In the search for novel treatments, pro-inflammatory cytokines have emerged as candidates to reactivate the immune system. Among those, interleukin 27 (IL-27) has recently gained attention, but its effects differ among malignancies. Here, we utilized the Eμ-TCL1 and EBI3 knock-out mouse models as well as clinical samples from patients to investigate the role of IL-27 in CLL. Characterization of murine leukemic spleens revealed that the absence of IL-27 leads to enhanced CLL development and a more immunosuppressive TME in transgenic mice. Gene-profiling of T-cell subsets from EBI3 knock-out highlighted transcriptional changes in the CD8+ T-cell population associated with T-cell activation, proliferation, and cytotoxicity. We also observed an increased anti-tumor activity of CD8+ T cells in the presence of IL-27 ex vivo with murine and clinical samples. Notably, IL-27 treatment led to the reactivation of autologous T cells from CLL patients. Finally, we detected a decrease in IL-27 serum levels during CLL development in both pre-clinical and patient samples. Altogether, we demonstrated that IL-27 has a strong anti-tumorigenic role in CLL and postulate this cytokine as a promising treatment or adjuvant for this malignancy.
Inhibition of GPIb-α-mediated apoptosis signaling enables cold storage of platelets
Authors: Marini Irene , Pelzl Lisann , Tamamushi Yoko , Maettler Chiara-Tanita , Witzemann Andreas , Althaus Karina , Nowak-Harnau Stefanie , Seifried Erhard , Bakchoul Tamam
Published: June 2023

Cold storage of platelets has been suggested as an alternative approach to reduce the risk of bacterial contamination and to improve the cell quality as well as functionality compared to room temperature storage. However, cold-stored platelets (CSP) are rapidly cleared from the circulation. Among several possible mechanisms, apoptosis has been recently proposed to be responsible for the short half-life of refrigerated platelets. In the present study, we investigated the impact of apoptosis inhibition on the hemostatic functions and survival of CSP. We found that blocking the transduction of the apoptotic signal induced by glycoprotein Ib (GPIb)-α clustering or the activation of caspase 9 does not impair CSP functionality. In fact, the inhibition of GPIb-α clustering mediated-apoptotic signal by a RhoA inhibitor better conserved δ granule release, platelet aggregation, adhesion and the ability to form stable clots, compared to untreated CSP. In contrast, upregulation of the protein kinase A caused a drastic impairment of platelet functions and whole blood clot stability. More importantly, we observed a significant improvement of the half-life of CSP upon inhibition of the intracellular signal induced by GPIb-α clustering. In conclusion, our study provides novel insights on the in vitro hemostatic functions and half-life of CSP upon inhibition of the intracellular cold-induced apoptotic pathway. Our data suggest that the combination of cold storage and apoptosis inhibition might be a promising strategy to prolong the storage time without impairing hemostatic functions or survival of refrigerated platelets.
Pollen morphology of twenty three species of Allium L. (Amaryllidaceae) species from Turkey
Authors: Yildiz Ümmügülsün
Published: June 2023

The pollen morphology of 23 Allium L. species, grown in Turkey, belonging to the sections; Rhizirideum, Schoenoprasum, Cepa, Molium, Brevispatha, Scorodon, Acanthoprason and Melanocrommyum, were investigated by LM (light microscopy), TEM (transmission electron microscope), and SEM (scanning electron microscopy). This paper presents detailed pollen morphological features are given for these taxa. Common characteristics of pollen of Allium species investigated are ellipsoidal and heteropolar, bilateral symmetry; pollen grains are shed as monads. They are monosulcate (extended sulcate types) and monosulcate-operculate. The sculpturing of the exine, pollen membrane ornamentation, lumina shape, and sulcus membrane with a fragmented operculum are found to be characteristic features for separating species. Based on these properties three main pollen types were determined with three different exine sculpturing. The characteristic structures of pollen ornamentation, observed in SEM micrographs, are striate­perforate, striate­regulate-perforate and regulate-perforate. Sulcus membrane ornamentations are psilate, psilate-perforate, rugulate and regulate-perforate. The exine is semitectate and the tectum perforate. Columellae were found to be simplicolumellate.
Bangladesh J. Plant Taxon. 30(1): 1-19, 2023 (June)
New records of Chaetoceros Ehrenberg from wetlands of Cox’s Bazar, Bangladesh
Authors: Jolly Jesmin Akhter , Alfasane Md Almujaddade , Khondker Moniruzzaman , Khan Md Sabbir Mustafa
Published: June 2023

Eleven species of marine Chaetoceros Ehrenberg newly recorded from Bangladesh have been illustrated and described in the present paper. The species are: Chaetoceros aequatorialis Cleve, C. constrictus Gran, C. decipiens Cleve, C. denicus Cleve,  C. didymus Ehrenberg, C. diversus Cleve, C. pelagicus Cleve, C. pendulus Karsten, C. pseudobrevis Pavillard, C. seychellarus G.H.H. Karsten and  C. tetrastichon Cleve. All of these species have been described here with citation of relevant references and collections examined.
Bangladesh J. Plant Taxon. 30(1): 37-41, 2023 (June)
A new species in genus Abutilon (Malvaceae) from Pakistan
Authors: Naseer Fouzia , Noor Ali , Rahman Afshan
Published: June 2023

In this research paper, a newly identified plant species of the genus Abutilon Mill., namely Abutilon jafrii F. Naseer, A. Noor & A. Rahman, is described and illustrated for the first time in the province of Sindh, Detailed morphological descriptions of the species along with the micro-morphological examinations of scanning electron microscopy (SEM) for the mericarps, seeds and pollens are presented. Additionally, Macro morphological characteristics including photographs of the plant habit with flowers, fruits, seeds and mericarps are provided. Through gross macro-morphological and micro-morphological investigations such as plant height, leaves texture and colour, pedicel of fruits and flowers, flowers diameter, sepal’s size in flowers and fruits, number of seeds per mericarp, pollen tectum exhibit significant differences in characters, which indicate that, it is a distinct species.
Bangladesh J. Plant Taxon. 30(1): 43-51, 2023 (June)
Consensus in the use of ethnomedicinal plants during COVID-19 pandemic in and around Dhaka city
Authors: Uddin Mohammad Zashim , Mazid Md Abdul , Hasan Md Siddiq , Shomrat Abulais , Suzana Noushin Sharmili , Saad Marzuk Ahmad
Published: June 2023

The present article deals with recording ethnomedicinal plants used by the people living in and around Dhaka city and also focuses on the plant species used during the pandemic to get relief from COVID-19. The information was gathered using open-ended and semi-structured questionnaires from 348 informants belonging to different classes of life. The survey has resulted in the recording of a total of 160 medicinal plant species belonging to 62 families and used for 157 ailments through 250 different formularies. Azadirachta indica A. Juss. was the most cited species in the study area. The highest factor informant consensus (FIC) was found in the Cuts and Wounds category, and Cynodon dactylon (L.) Pers. is the most cited species for this category. Acmella calva (DC.) R.K. Jansen was the culturally bound species attaining 100% Fidelity Level (FL) value. Among the ethnomedicinal plants, 40 species were found in the survey that were used by people to get relief from COVID-19. This interesting ethnomedicinal use is a new record for these 40 species. Most notable species are (Ocimum tenuiflorum L., Justicia adhatoda L., Centella asiatica (L.) Urban, Citrus aurantifolia (Christm. & Panzer) Swingle, Syzygium aromaticum (L.) Merr. & L.M. Perry, Mentha arvensis L., Zingiber officinale Rosc., Camellia sinensis (L.) O. Kuntze, and Nigella sativaL.Since ancient times, these species have been very popular and used to treat several ailments. The use of these species during the pandemic is a new hope to get relief from COVID-19 but this is very preliminary report. Further long-term study is needed to confirm the claim of these plants’ use against COVID-19. Due to excessive use during COVID-19, these species are very rare in the habitats in and around Dhaka city. Conservation measures should be applied to save these species from extinction.
Bangladesh J. Plant Taxon. 30(1): 123-151, 2023 (June)
Seaweed flora of the St. Martin’s Reef, Bangladesh
Authors: Aziz Abdul , Kabir Shahriar , Alfasane Md Almujaddade
Published: June 2023

St. Martin’s Reef (SMR) about 14 km west of the St. Martin’s Island, Teknaf, Cox’s Bazar, Bangladesh was not known during last over 50 years of seaweed researches. Recent six collections made with the assistance of Bangladesh Navy revealed 8 seaweeds species which are Pterocladiella maribagoensis Boo and Geraldo, Hypnea spinella (C. Agardh) Kützing, Peyssonnelia polymorpha (Zonars.) Schmitz, Jania pumila Lamx.,  Jania ungulata f. brevior (Yendo) Dawson (Rhodophyta); Caulerpa racemosa var. clavifera (Turner) Bosse, Bryopsis plumosa (Huds.) C. Ag. and Halimeda tuna (Lin.) Lamx. (Chlorophyta). Of these six seaweeds such as Pterocladiella maribagoensis Boo et Geraldino, Hypnea spinella (C. Agardh) Kützing,  Jania pumila Lamx., Jania ungulata f. brevior (Yendo) Dawson,  Bryopsis plumosa (Huds.) C. Ag. and Halimeda tuna (Lin.) Lamx have been newly recorded and described from the SMR in Bay of Bengal (Bangladesh territory). Presence of Peyssonnelia polymorpha and Bryopsis plumosa in the collections and physical and chemical water environments recorded indicated it as a true newly forming reef. The present illustrated account is however may be considered as base-line information on seaweed flora of the new SMR in the North-east Bangladesh coast. A total of six seaweeds have been newly recorded making the total seaweeds to 215 mostly from the SMI and nearby SMR.
Bangladesh J. Plant Taxon. 30(1): 153-163, 2023 (June)
Optimizing Micropropagation Protocol of Rose (Rosa hybrida L.) cv. ‘Double Delight’
Authors: Rahman Kazi Tanbir , Sarker Snigdha , Raju Md Raihan Iqbal , Hossain Mohd Talim
Published: June 2023

An experiment was conducted to develop a suitable in vitro plant regeneration technique for Rosa hybrida L. cv. ‘Double Delight’ using nodal segments and leaf tissues as explants through direct and indirect organogenesis. Aseptic explants were inoculated onto gelled MS medium contained various strengths of plant growth regulators alone and in combinations for callus and direct shoot induction. MS medium containing 2.0 mg/l BAP was found to be the most effective for direct shoot induction from nodal explants (87.5%) as it produced the maximum number of shoots per explant. The highest callus induction frequency was found to be 80% in leaf tissue, 72% in nodal segments and 96% in leaf and intermodal segments of in vitro raised plantlets in MS medium containing 2.5 mg/l 2, 4-D. The best percentage of indirect shoot organogenesis (93.33%) with maximum number and length of shoot were found when the different explant-derived callus was transferred in 3.0 mg/l BAP supplemented medium. The direct and indirectly induced shoots were multiplied on MS medium containing 3.0 mg/l BAP, where the average number and length of shoots per culture were 7.20 ± 0.80 and 5.22 ± 0.47 cm, respectively. Maximum rooting (80%) was observed in ½-strength of gelled MS medium containing 15.0 g/l sucrose with 1.0 mg/l IBA. Plantlets with the proper root system were then placed in a polybag with a 1:1:1 ratio of sand, garden soil, and compost, and they had a survival rate of about 76%.
Plant Tissue Cult. & Biotech. 33(1): 25-36, 2023 (June)
Phylogenetic Relationship among Grasses, Wheat and Pearl Millet using matK and rbcR Genes
Authors: Molla M M H , Saha M C , Serba D , Talukdar S K , Salam M A , Ahmed M Shahabuddin , Islam M S
Published: June 2023

Fourteen genotypes of tall fescue, Brachypodium, wheat and pearl millet were used to find out phylogenetic relationships at their different ploidy level. Isolated chloroplast DNA of the 14 genotypes was sequenced using some selected matK and rbcR genetic markers. The matK and rbcR chloroplast gene sequences length were 1539bp and 1431bp, respectively. The consensus sequence length of matK gene was 1265bp in Brachypodium and wheat, 1266bp in both tall fescue Continental and Mditerranean species, 1269bp in pearl millet and for rbcR gene was only 1156bp in all studied four species. Except in Brachypodium, the variations of SNP for both matK and rbcR genes were observed in different ploidy levels of pearl millet and between the tall fescue Continental and Mediterranean species. Wheat with their different ploidy level gave the SNP variations only for matK gene. In respect of all ploidy levels, pearl millet had the highest number of SNP for both matK (247) and rbcR (130) genes. The tall fescue Continental (129) and Mediterranean (123) were in second position to show their genetic variation for matK gene. The rbcR gene had higher SNP at 5¢ regions of all four species, but matK gene only in wheat and tall fescue and 3¢ in millet and Brachypodium species. There was no in-del for rbcR gene, but the insertion of nucleotide for the matK gene was found highest in diploid wheat (11) and the deletion was in pearl millet (6). The phylogenetic analysis stated that their relationships were tall fescue Continental and tall fescue Mediterranean was much more related to wheat than pearl millet and Brachypodium.
Plant Tissue Cult. & Biotech. 33(1): 57-70, 2023 (June)
Operation and Performance of Sufi-Led Political Parties in Contemporary Bangladesh
Authors: Mostofa Mamun Al
Published: June 2023

Although Sufi-led political parties have been active in Bangladesh for almost four decades, they have received little scholarly attention. Therefore, this article discusses the historical context within which post-independence Sufi/Pir-centred political parties emerged, their interaction with other parties, and their electoral performance. It also touches upon some basic issues relating to Pir-cum political leaders: once a Pir becomes a politician, does his previous relationship with his murids (disciple) remain intact? This paper concludes that instead of posing any meaningful challenge to the political regimes, Pir-led parties have developed a tendency to maximise their political opportunities by reaching various kinds of agreements with dominant political parties.
Social Science Review, Vol. 39(2), June 2022 [Special Issue] Page 59-78
(Re)Visiting Private Television Research in Bangladesh: Call for New Research Agenda in News Media Study
Authors: Rahman Atiqur , Rahman Habiba
Published: June 2023

Private television is the most popular mass media in Bangladesh with a vast audience of both news and programs. However, research on private television and its news media has not advanced sufficiently. Analysing available research on different databases this study identifies general trends in Bangladesh’s private television and its news media research which shows that in addition to low volume of research, most of the study focused on some common aspects resulting in many significant areas unexamined. Finally, this article suggests new agendas in news media research with particular focus on the role of the state, ownership and news labour—three key stakeholders of the private television news media. This investigation will contribute to the scholars and industry insiders to identify the gap in private television research, especially in relation to the news media, and take necessary initiatives.
Social Science Review, Vol. 39(2), June 2022 [Special Issue] Page 79-98
UNA TEORÍA DE LA SIGNIFICACIÓN PARA EL DISEÑO DE LOS SIGNIFICADOS ESTIMULADOS POR LAS FORMAS Y ESPACIALIDADES ARQUITECTÓNICAS
Authors: Pokropek Jorge
Published: June 2023

El presente escrito pretende explicar de un modo resumido un conjunto de conceptos y estrategias que favorezcan el diseño eficaz de los diversos mensajes que, tanto las formas en general, como las espacialidades habitables en particular, tienden a vehiculizar merced a su condición de sistemas de signos, estimulando en los fruidores o habitantes, emociones y conductas coherentes o contradictorias con las prácticas sociales que demandaron la generación de dichas formas y espacialidades. Estos conceptos y estrategias configuran una Teoría de la Significación que opera dialécticamente con una Teoría Estética del modo poético de regular el estar de las formas, y con una Teoría de la Espacialidad Arquitectónica. Juntas configuran una Teoría del Proyecto Poético que actúa dialécticamente en la determinación de una Teoría de la Arquitectura, que pretende renovar y mejorar la práctica y la enseñanza del proyecto. Esta teoría del Proyecto Poético constituye nuestra tesis doctoral que ha sido resumida en otros escritos.

Palabras clave: Arquitectura, espacio, poética, proyecto, retórica.

AbstractThis paper aims to explain in a summarized way a set of concepts and strategies that favor the effective design of the various messages that, both shapes in general and inhabitable spatialities in particular, tend to convey thanks to their condition as sign systems. , stimulating in the users or inhabitants, emotions and behaviours that are coherent or contradictory with the social practices that demanded the generation of said forms and spatialities.These concepts and strategies configure a Theory of Signification that operates dialectically with an Aesthetic Theory of the poetic way of regulating the being of forms, and with a Theory of Architectural Spatiality. Together they configure a Theory of the Poetic Project that acts dialectically in the determination of a Theory of Architecture, which aims to renew and improve the practice and teaching of the project. This theory of the Poetic Project constitutes our doctoral thesis that has been summarized in other writings.Keywords: Architecture, space, poetics, project, rhetoric.
Mainiossa kirjassa koulutuksen käsittely jää sivurooliin
Authors: Rantala Jukka
Published: June 2023

Arvosteltu teos: Immonen, Perttu 2023. Suomalainen historia. Kolmen suvun elämää keisariajalta 2000-luvulle. Jyväskylä: Atena. 646 s.
Kriittisen ajattelun kasvatustavoitteen rajat ja mahdollisuudet
Authors: Pettersson Henri
Published: June 2023

Lectio praecursoria kasvatustieteen väitöskirjaan Reason to believe: The prospects and limitations of critical thinking as an educational ideal, Oulun yliopistossa 23.3.2023.
Aspek Internal dan Eksternal Keberdayaan Kelompok Pembudidaya Ikan di Kota Tasikmalaya
Authors: Hanan Abdul , Eliyani Yuke , Sumartini Decu , Heryadi Dedi , Mawi Fauzia Rahman
Published: June 2023

Kota Tasikmalaya merupakan salah satu sentra budidaya ikan di Provinsi Jawa Barat. Pembudidaya di Kota Tasikmalaya tergabung dalam kelompok pembudidaya yang setiap kelompok biasanya terdiri atas 15 orang anggota. Dengan adanya pandemi Covid-19, pembudidaya ikan sebagian tidak melanjutkan usaha budidaya. Penelitian ini bertujuan untuk menguraikan secara detail derajat keberdayaan pembudidaya ikan di Kota Tasikmalaya yang ditinjau dari aspek internal dan eksternal pembudidaya. Penelitian ini dilakukan di Kota Tasikmalaya pada Oktober-Desember 2021. Desain penelitian berupa survei dengan kuesioner terstruktur dengan skala pengukuran ordinal. Keseluruhan responden adalah 81 orang pembudidaya yang masing-masing mewakili 1 kelompok perikanan. Terdapat empat derajat keberdayaan yang diukur, yakni tingkat kesadaran dan keinginan berubah, kemampuan meningkatkan kapasitas untuk memperoleh akses, kemampuan menghadapi hambatan, kemampuan kerja sama dan solidaritas. Data yang diperoleh dianalisis secara deskriptif. Hasil penelitian memperlihatkan bahwa pembudidaya ikan memiliki derajat keberdayaan yang tinggi pada tingkat kesadaran dan keinginan berubah (power to) dan kemampuan kerja sama dan solidaritas (power with), kemudian memiliki kemampuan yang sedang dalam menghadapi hambatan (power over), namun memiliki kemampuan yang rendah dalam memperoleh akses usaha (power within) tergolong rendah.
Haematological and Biochemical Anomalies in Catfish, Clarias batrachus due to
Cutaneous Ulcerations
Authors: Ali Haidar , Ansari Samreen
Published: June 2023

The present study was carried out to investigate the haematological and biochemical parameters in healthy and ulcerated Catfish, Clarias batrachus. The haemorrhagic necrotic skin lesions in ulcerated fishes showed significant reduction (P<0.01) in RBC, haemoglobin, haematocrit (PCV) eosinophils and lymphocytes. The derived erythrocyte indices, namely, the MCV, MCH and MCHC of ulcerated fishes were also significantly decreased (P < 0.05) from those of normal fishes. Whereas, the total leucocyte count (TLC), neutrophils, monocytes and ESR were significantly increased (P<0.01 and P<0.05) in infected fishes. The biochemical analysis showed a significant reduction (P<0.01) in bilirubin content, whereas the blood glucose, SGOT and SGPT were significantly increased (P<0.01).
Pertanggungjawaban Pidana Korporasi Dalam Pengadaan Barang/Jasa Menggunakan Metode Penunjukan Langsung
Authors: Pratama Wahyudia , Ucuk Soyono Yoyok
Published: June 2023

Tulisan ini bertujuan untuk mengkaji tindak pidana dalam pengadaan barang/ jasa Badan Usaha Milik Negara dengan penujukan langsung serta bentuk pertanggungjawaban korporasi atas tindak pidana tersebut. Penelitian ini menggunakan metode yuridis normatif dengan pendekatan konseptual, perundang-undangan, dan kasus. Masalah yang sering terjadi dalam pengadaan barang/ jasa dengan penunjukan langsung adalah adanya persekongkolan dan/atau suap antara calon penyedia jasa dengan pengguna anggaran atau antara panitia pengadaan yang bertujuan demi keuntungan pribadi maupun kelompok tertentu. Pertanggungjawaban pidana dalam suatu kejahatan korporasi dalam pengadaan barang/ jasa dengan penunjukan langsung seperti kejahatan terkait dengan tindak pidana korupsi dan persaingan usaha tidak sehat adalah dijatuhi pidana pokok berupa pidana denda, perampasan barang, penutupan sementara korporasi, penutupan perusahaan dan pencabutan hak-hak tertentu atau penghapusan seluruh atau sebagian keuntungan.
Perlindungan Hukum Terhadap Direksi Atas Keputusan Bisnisnya Sesuai Prinsip Business Judgement Rule
Authors: Damara Eko Prasetyo Doni , Badrus Salam Robieth As Syadili Muhammad , Yulianingsih Yulianingsih
Published: June 2023

Tujuan penelitian ini ialah untuk mengetahui eksistensi business judgement rule di Indonesia sehingga dapat dijadikan acuan dalam melindungi direksi atas keputusan bisnis yang dibuat. Jenis penelitian ini ialah yuridis normative dengan pendekatan perundang-undangan, kasus, dan konseptual. Hasil dari penelitian ini ialah prinsip business judgement rule memberikan perlindungan terhadap direksi. Prinsip ini diatur dalam Pasal 97 Ayat (5) Undang-Undang Nomor 40 Tahun 2007 tentang Perseroan Terbatas, sehingga berdasarkan pasal tersebut jika terpenuhi secara kumulatif oleh direksi maka direksi dapat dibebaskan dari segala pertanggung jawaban dan mendapatkan perlindungan hukum dari prinsip business judgement rule yang diberikan kepada dirinya atas keputusan bisnis yang dilakukan.
Identification and utilization of medicinal plants in the village of the Kesatuan Pemangkuan Hutan (KPH) Saradan, Madiun
Authors: Prameswari Yuanita , Dewi Nurul Kusuma , Yuhanna Wachidatul Linda
Published: June 2023

The diversity of plants in Indonesia means that many plants have the potential to be used as medicine by the community. Because of its potential as a medicine, many people do not know about it, so it is important to study it. The use of medicinal plants by the community has been passed down from generation to generation, so there is still a lack of documentation regarding the use of medicinal plants. This study aims to identify medicinal plants in the Saradan Kesatuan Pemangkuan Hutan (KPH) area as well as the utilization of plants that are often used as medicine by the community in the Saradan KPH area. The research was conducted in March 2022. Ethnobotanical data were collected using the roaming method and the structured interview method using ethnobotanical interview sheets. Identification of medicinal plants using the help of books on medicinal plants by Widyaningrum. The selection of respondents was carried out randomly, according to the study, which documented 32 species of medicinal plants from 18 families. The most commonly found families of medicinal plants are the Zingiberaceae and Euphorbiaceae families. The leaves are the most useful part of the plant. and the method of treatment with medicinal plants is mostly done by boiling and pounding. The medicinal plant diversity documented in KPH Saradan village is 32 species. Ocimum basilicum L., Alpinia Galanga L. Willd., Zingiber officinale Rosc., and Curcuma domestica Val. medicinal plants that are most widely used by the community around KPH Saradan.
THE EFFECTIVENESS OF USING SMARTPHONE IN LEARNING ENGLISH AT SMA NEGERI 3 BUKITTINGGI
Authors: Lestari Fadiah , Eliza  , Darmawati
Published: June 2023

This article aims to reveal the effectiveness of using Smartphones in learning English. The problem of the research was  students werelessed motivated by the old learning media, students felt bored and lessed interested in learning through lecturedAnd lastly, studentswere sometimes embarrassed to asked directly to the teacher and prefer smartphones. Therefore, researcher was conducted a research at SMAN 3 Bukittinggi to found out whether the uses of smartphones was effective or not for learning English. This research was quantitative. The researcher used simple random sampling to determine the sample because it uses one way to pull out the lottery. The researcher was chose one of the five classes as the sample. The sample in this research were 36 students of class X E4. The data collection technique in this research  was documentation in the form of student scores. The results showed that the use of smartphones was effective in learning English. The percentage of students was  between 61 – 80% with the mean score calculated as 78,89with an effective assessment quality. This means that the data proves that the use of smartphones is effective in learning English in class X E4 SMAN 3 Bukittinggi.
PENGARUH MEDIA NYATA TERHADAP HASIL BELAJAR IPA MATERI AKAR DAN BATANG KELAS IV DI SDN GEMPOL I
Authors: Rachmawati Dwi Sari , Setiyawati Enik
Published: June 2023

Media pembelajaran merupakan alat yang digunakan guru dalam memberikan materi belajar di dalam kelas. Penelitian ini akan menunjukkan pengaruh media nyata terhadap hasl pembelajaran materi IPA akar dan batang pada kelas IV SDN Gempol 1. Penelitian ini menggunaka jenis penelitian kuantitatif pra eksperimen. Pengumpulan data menggunakan soal tes dengan uji validitas dan reliabilitas instrumen. Teknik analisis data menggunakan N-Gain dengan perhitungan selisih antara pre tes dan post tes. Hasil dari penelitian ini menunjukan media pembelajaran nyata berpengaruh terhadap hasil belajar kognitif siswa yang ditunjukan dengan adanya peningkatan hasil nilai siswa. Dapat dibuktikan pada Uji Independent Sample T-Test menunjukkan hasil nilai rata-rata pre test adalah 35.57 dan hasil nilai rata-rata post test adalah 78.57, maka dari hasil rata-rata menunjukkan peningkatan pada nilai kognitif. Serta dapat dibuktikan dalam uji N-Gain menunjukkan hasil pre test dan post test pada 19 siswa berkategori tinggi dan efektif, 15 siswa berkategori sedang dan cukup efektif dan 1 siswa berkategori rendah dan tidak efektif. Dari data diatas siswa yang berkategori sedang ke atas adalah 34 siswa maka 97% menunjukkan adanya peningkatan nilai siswa setelah menggunakan media nyata oleh karena itu ada pengaruh yang besar dalam Pengaruh media nyata terhadap hasil belajar materi IPA akar dan batang pada kelas IV di SDN Gempol I.
PENDIDIKAN LITERASI DALAM PROGRAM DESA BAHASA BOROBUDUR
Authors: Fadilla Annisa Rizky , Wulandari Putri Ayu
Published: June 2023

Penelitian ini bertujuan untuk mendeskripsikan: (1) mendeskripsikan wujud program dalam menumbuhkembangkan budaya literasi di Desa Bahasa Borobudur, dan (2) mendeskripsikan pengaruh program penumbuhkembangan budaya literasi terhadap tingkat literasi masyarakat di Desa Bahasa Borobudur. Penelitian ini menggunakan penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data penelitian ini dilakukan dengan cara: (1) observasi partisipan, dan (2) wawancara mendalam. Instrumen penelitian pengembangan ini berupa peneliti, buku catatan, tape recoder (audio/video), kamera, lembar panduan wawancara, lembar panduan observasi, transkrip hasil wawancara, dan lembar analisis dokumen. Subjek penelitian pengembangan ini adalah pengelola, peserta, dan masyarakat sekitar Desa Bahasa Borobudur. Subjek penelitian adalah pengelola dengan jumlah tiga orang (satu perintis dan dua staf), peserta dengan jumlah dua orang, dan satu orang kepala dusun. Teknik analisis data menggunakan teknik kualitatif. Keabsahan data menggunakan triangulasi. Hasil penelitian menunjukkan bahwa wujud program pendidikan literasi di Desa Bahasa Borobudur berupa wujud nonfisik (program pengajaran lima bahasa) yaitu program utama Desa Bahasa Borobudur, SPEC, Pesantren Bahasa, dan Kedai 3 Bahasa. Wujud fisik berupa pengadaan fasilitas utama dan fasilitas pendukung pendidikan literasi. Wujud program literasi di Desa Bahasa Borobudur telah memenuhi prinsip pendidikan literasi dan prinsip program Gerakan Literasi Nasional (GLN). Selain itu, hasil penelitian juga menunjukkan bahwa Desa Bahasa Borobudur cukup berpengaruh dalam upaya penumbuhkembangan budaya literasi dan tingkat literasi masyarakat, baik dalam bidang kecakapan berbahasa maupun bidang kehidupan masyarakat yang lain. Hasil penelitian dapat membantu masyarakat, pemerintah, dan peneliti untuk memahami pentingnya pendidikan literasi bagi kehidupan
PENGARUH PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN TERHADAP PEMBENTUKAN KARAKTER DISIPLIN SISWA DI SMA NEGERI 2 PANGKALAN KERINCI KABUPATEN PELALAWAN
Authors: Inzaghi Filippo Pippo , Edison Ahmad , Arianto Jumili
Published: June 2023

Tujuan penelitian adalah untuk mengetahui pengaruh Pendidikan Pancasila dan Kewarganegaraan terhadap pembentukan karakter disiplin siswa di SMA Negeri 2 Pangkalan Kerinci Kabupaten Pelalawan. Populasi penelitian berjumlah 750 orang dengan menggunakan teknik pengambilan sampel yaitu teknik proposional random sampling. Metode pengumpulan data yang digunakan yaitu wawancara, observasi, angket dan dokumentasi, penelitian ini menggunakan analisis regresi linier sederhana bertujuan mengetahui pengaruh variabel (X) terhadap variabel (Y).Hasil menunjukan bahwa ada pengaruh Pendidikan Pancasila dan Kewarganegaraan terhadap Pembentukan Karakter Disiplin Siswa di SMA Negeri 2 Pangkalan Kerinci Kabupaten Pelalawan sebesar 51,4%.
Железобетонные здания с сейсмоизолирующим скользящим поясом в уровне фундамента
Authors: МКРТЫЧЕВ Олег Вартанович , МИНГАЗОВА Салима Рафиловна
Published: June 2023

Проведен сравнительный анализ работы одномассового осциллятора и монолитного железобетонного здания с сейсмоизоляцией в виде скользящего пояса в уровне фундамента, резинометаллических и маятниковых скользящих опор при сейсмическом воздействии. При проведении исследования использовался прямой динамический метод, основанный на явной схеме интегрирования уравнения движения (метод центральных разностей). Получены графики относительных сдвиговых перемещений нижнего, среднего и верхнего яруса пяти- и шестнадцатиэтажного здания с резинометаллическими и маятниковыми скользящими опорами, скользящим поясом в уровне фундамента, а также картины с изополями интенсивности напряжений для всего здания и наиболее нагруженного этажа. Анализ полученных результатов показал, что для рассматриваемых ситуаций, эффективность применения сейсмоизолирующего скользящего пояса уступает эффективности резинометаллических и маятниковых скользящих опор. Однако, принимая во внимание относительную простоту конструкции, устройства, обслуживания и сметную стоимость скользящего пояса, данный вид сейсмоизоляции может конкурировать с резинометаллическими и маятниковыми скользящими опорами.
Опыт замены нижнего пояса находящейся под нагрузкой подкраново-подстропильной фермы
Authors: ТУСНИНА Ольга Александровна , ТАККИ Владимир Федорович , ЕГОРОВ Игорь Федорович
Published: June 2023

Большое количество ныне действующих цехов металлургической промышленности было построено пятьдесят лет назад и эксплуатируется в условиях тяжелого непрерывного режима работы кранов, в ряде случаев при повышенных температурах. При таких условиях работы наиболее повреждаются подкрановые конструкции, которые исчерпывают эксплуатационный ресурс намного раньше прогнозируемого. Характер и количество дефектов зачастую не позволяют ограничиться ремонтом и требуют полной замены поврежденной подкрановой конструкции. Традиционная замена исчерпавших ресурс конструкций эксплуатируемого здания новыми и более совершенными элементами не всегда возможна без демонтажа примыкающих конструкций, нарушения или остановки технологического процесса, что категорически неприемлемо для непрерывно действующих производств. В статье рассмотрено восстановление выработавшей эксплуатационный ресурс подкраново-подстропильной фермы в конвертерном цехе металлургического комбината. За период эксплуатации основные конструкции подкраново-подстропильной фермы претерпели большой износ и получили повреждения, а нижний коробчатый пояс практически утратил несущую способность. Реконструкция была успешно реализована в полном объеме. Благодаря тщательно проведенному проектному и расчетному сопровождению монтаж усиления был выполнен в крайне короткие сроки.
Геотехнический мониторинг морозного пучения грунтов
Authors: АЛЕКСЕЕВ Андрей Григорьевич
Published: June 2023

Наблюдения за напряженно-деформированным состоянием и температурным режимом грунтов основания - важная научно-практическая задача. Промерзание грунта приводит к деформированию поверхности грунта, фундаментов и сооружений, расположенных на пучинистых грунтах. Статья содержит регламент проведения геотехнического мониторинга морозного пучения грунтов. Представлены контролируемые параметры при морозном пучении, средства контроля, места расположения и периодичность проведения замеров. К основным контролируемым параметрам относятся: температура грунта, глубина его промерзания, деформации поверхности грунта и фундаментов (сооружений), а также уровень подземных вод. При расположении малонагруженных сооружений в сильнопучинистых грунтах требуется определение напряжений пучения - нормального давления и касательных сил морозного пучения грунта. Наблюдения выполняются в течение нескольких зимних периодов или в период эксплуатации ответственных сооружений.
Как быть с нормированием сейсмостойкого строительства
Authors: ИЛЬИЧЕВ Вячеслав Александрович , УЗДИН Александр Моисеевич , БЕЛАШ Татьяна Александровна , ТЯПИН Александр Георгиевич
Published: June 2023

В статье отмечается, что старые нормы сейсмостойкого строительства были одними из лучших в мире, но в последние четыре десятилетия они не менялись и не развивались. Сейсмостойкое строительство ушло на десятилетия вперед, и настало время создания современных норм нового поколения. Авторы изложили свою позицию по созданию таких норм. Эта позиция включает в себя восемь принципов: повышение ответственности и надежности проектирования; переход на многоуровневое проектирование; замену карт общего сейсмического районирования простой связью балла с повторяемостью воздействий; отказ от целочисленных баллов; использование новой шкалы балльности; применение современных пространственных моделей сооружений; энергетические критерии возникновения предельных состояний; регламентацию специальных методов сейсмозащиты; обеспечение страхования последствий землетрясений. Выполнено детальное исследование каждого принципа и сделаны выводы по итогам работы.
Инжиниринг пусконаладочных работ при строительстве объектов использования атомной энергии
Authors: САВЕНКОВ Андрей Николаевич , МАКАРОВ Александр Николаевич
Published: June 2023

Рассмотрены основные направления инвестиций в атомной отрасли. Изучены инжиниринговые схемы управления строительством объектов использования атомной энергии, проанализированы организационно-технологические решения и организационные схемы, в том числе на предмет их оптимизации. Показано, что важным направлением развития инжиниринга, включая и пусконаладочные работы, становится цифровизация. Отмечено, что главный результат инжиниринговой деятельности по вводу в эксплуатацию энергоблоков атомных электростанций - получение и использование в дальнейшей деятельности фактической информации в виде баз данных. При этом развитием может стать расширение практики разработки и утверждения типовых как технологических карт процессов, так и программ проведения пусконаладочных работ. Предложены решения задач по повышению производительности труда и установлению объективных норм труда. Указанные мероприятия позволят сформировать корпоративную нормативную базу по труду, которая станет основной для разработки необходимых отрасли нормативов. Кроме того, появится возможность изучать организационно-технологические схемы выполнения работ в целях подготовки предложений по их оптимизации и разработки типовых корпоративных документов и стандартов. Предлагаемые новации позволят заложить основу для эффективного решения сложившихся в настоящее время проблем в инвестиционно-строительной деятельности атомной отрасли и использовать положительный опыт для урегулирования аналогичных вопросов в других сферах и секторах национальной экономики.
Основы разработки технологических карт строительных процессов по аддитивным технологиям
Authors: МУХАМЕТЗЯНОВ Зинур Ришатович , КАМЕНСКАЯ Алина Вячеславовна
Published: June 2023

Отличительная особенность строительного производства - высокие трудозатраты и низкий уровень механизации и автоматизации производства работ. При этом обновление технологий здесь происходит не так часто, как в других отраслях промышленности. Показано, что использование аддитивных технологий может существенно повысить производительность работ в строительной отрасли. Несмотря на некоторые недостатки, трехмерная печать помогает увеличить объемы производства, уменьшить затраты, а также снизить количество отходов. Однако для широкого внедрения этого метода серьезным препятствием является отсутствие полноценной нормативно-технической базы, обеспечивающей качественное функционирование данной технологии. Для решения этой проблемы предлагается создание технологических карт, используемых при строительной 3D-печати, которые играют ключевую роль при формировании нормативной документации. Выявлены важные особенности технологических процессов, напрямую влияющих на производительность, течение работы и результат производства. Приводятся пути решения проблемы недостаточности нормативно-технической базы при использовании аддитивных технологий.
«Зеленые» решения жилищного строительства на этапах жизненного цикла объекта
Authors: ВЛАДИМИРОВА Ирина Львовна , ДМИТРИЕВ Александр Николаевич , КАЛЛАУР Галина Юрьевна , ЦЫГАНКОВА Анна Аристокесовна
Published: June 2023

Статья посвящена проблемам развития "зеленого" жилищного строительства в связи с утверждением ГОСТ Р 70346-2022 "Зеленые" стандарты. Здания многоквартирные жилые "зеленые". Методика оценки и критерии проектирования, строительства и эксплуатации". Приведены требования к объектам сертификации по разным категориям стандарта и предложены методы управления соответствующими разделами проекта на разных стадиях жизненного цикла многоквартирных домов. Проанализирован практический опыт сертификации объекта жилищного строительства в Москве по "зеленому" стандарту на оценку "хорошо". Представлен анализ возможностей управления энергосберегающими технологическими решениями по категории "Энергоэффективность и атмосфера" рассматриваемого стандарта, включая международную практику комишенинга. Приведен технико-экономический анализ применения в отечественной практике гибридных теплонасосных систем для тепло- и холодоснабжения объектов капитального строительства. Даны предложения по созданию соответствующих баз данных по "зеленым" энергосберегающим технологическим решениям на основе практического пособия по повышению энергоэффективности многоквартирных домов и решений Московского территориального строительного каталога.
Комплексная диагностика подтопления берегов водохранилища Витебской гидроэлектростанции
Authors: ЛЕВКЕВИЧ Виктор Евгеньевич , ЕРЕСЬКО Марина Анатольевна
Published: June 2023

Приведены некоторые результаты комплексных исследований по оценке масштабов и ширины зоны подтопления прибрежных территорий водохранилища Витебской гидроэлектростанции (Республика Беларусь), проведенных с помощью наземных и дистанционных съемок беспилотных летательных аппаратов. В статье показана возможность интеграции и совместимости прогнозных характеристик береговой фильтрации и подпора подземных вод, получаемых на основе использования как аналитических зависимостей и материалов натурных измерений, так и информации, собираемой средствами дистанционного зондирования земной поверхности. Комплексные исследования показали эффективность и перспективу совместного использования классических методов, включающих в себя расчетные и полевые в сочетании с современными средствами оперативной оценки изучаемого объекта.
Памятники архитектуры в период Великой Отечественной войны: урок истории
Authors: ПРЯДКО Игорь Петрович
Published: June 2023

Цель данной работы состоит в том, чтобы пролить свет на состояние архитектурных памятников в период Великой Отечественной войны. Утрата объектов культурного наследия, музейных экспонатов, разрушение исторических зданий, архитектурных ансамблей в пригородной зоне в период гитлеровской оккупации рассматриваются в ряду целенаправленного уничтожения городов и их пригородов в Европейской части СССР, которое современными историками архитектуры определяется как урбицид. В статье затронут вопрос использования исторических зданий и сооружений в период Великой Отечественной войны. Подвиг реставраторов и музейных работников советского времени противопоставляется событиям конца XX-начала XXI вв., когда большое число памятников истории и архитектуры оказались утрачены. В работе осуществлен ретроспективный анализ источников, сопоставляются архивные данные, документы периода Великой Отечественной войны, факты, приводимые авторитетными учеными - музееведами и реставраторами. Исследование имеет практическое значение, так как позволяет взять на вооружение применявшиеся послевоенными реставраторами приемы восстановления архитектурных сооружений.
PENGEMBANGAN KOMPETENSI SUMBER DAYA APARATUR MELALUI DIKLAT TEKNIS PADA BADAN KEPEGAWAIAN PENDIDIKAN DAN PELATIHAN DAERAH KABUPATEN MAGELANG PROVINSI JAWA TENGAH
Authors: Hidayat Fahmi , Saputra Romi , Nurrahman Agung
Published: June 2023

Fokus penulis dalam penelitian ini ada pada pengembangan kompetensi melalui Diklat teknis di Badan Kepegawaian Pendidikan dan Pelatihan Daerah Kabupaten Magelang Provinsi Jawa Tengah. Tujuan penelitian ini adalah untuk untuk mengetahui dan menganalisis mengenai pengembangan kompetensi sumber daya aparatur melalui Diklat teknis di Kantor Badan Kepegawaian Pendidikan dan Pelatihan Daerah Kabupaten Magelang. Penelitian ini merupakan penelitian kualitatif dengan metode deskriptif. Hasil penelitian menunjukkan bahwa pelaksanaan pengembangan kompetensi sumber daya aparatur di Badan Kepegawaian Pendidikan dan Pelatihan Daerah Kabupaten Magelang sudah baik, hal ini dapat terlihat dari kinerja pegawai di Kabupaten Magelang pada umumnya sudah berkompeten. Namun masih ada beberapa kendala dalam penyelenggaraan Diklat teknis tersebut yang menyebabkan hasil pelaksanaan Diklat kurang optimal.

 

Kata Kunci : Pengembangan, Kompetensi, Diklat teknis
STUDI FENOMENOLOGI PERILAKU CYBERLOAFING PNS DI BADAN KEPEGAWAIAN DAN PENGEMBANGAN SUMBER DAYA MANUSIA KABUPATEN KARANGASEM PROVINSI BALI
Authors: Tefa Gradiana , Mahendra Made Agus
Published: June 2023

Katalisasi aktivitas layanan internet broadband berkoherensi terhadap organisasi guna menunjang produktivitas. Hal ini memunculkan suatu fenomena cyberloafing. Aktivitas cyberloafing membawa banyak kerugian bagi instansi, baik produktivitas, beban biaya internet yang tinggi bahkan mengganggu hubungan interpersonal akibat adiksi internet. Tujuan dari penelitian ini ialah untuk mengetahui penyebab kausal dalam perilaku cyberloafing PNS di BKPSDM Kabupaten Karangasem serta bagaimana upaya untuk mengatasinya melalui kajian teori Atribusi Kausal. Pendekatan dalam penelitian ini ialah studi fenomenologi dengan metode penelitian kualitatif. Hasil penelitian menunjukkan bahwa atribusi kausal perilaku PNS di BKPSDM Kabupaten Karangasem disebabkan oleh faktor situasional atau eksternal yang berasal dari lingkungan dan budaya organisasi. Atribusi situasional yang terjadi merupakan intepretasi dari karakteristik organisasi atau lingkungan sehingga upaya yang dilakukan berupa rekontroksi terkait : (1) Hierarki kerja; (2) Tugas-wewenang; (3) Tanggung jawab; (4) Sistem reward; (5) Sistem kontrol/pengawasan.