bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Media Browsing and Adolescent Well-Being: Challenging the “Passive Social Media Use Hypothesis”
Authors: Valkenburg Patti M , Beyens Ine , Pouwels J Loes , van Driel Irene I , Keijsers Loes
Published: August 2021

A recurring hypothesis in the literature is that “passive” social media use (browsing) leads to negative effects on well-being. This preregistered study investigated a rival hypothesis, which states that the effects of browsing on well-being depend on person-specific susceptibilities to envy, inspiration, and enjoyment. We conducted a three-week experience sampling study among 353 adolescents (13–15 years, 126 assessments per adolescent). Using an advanced N = 1 method of analysis, we found sizeable heterogeneity in the associations of browsing with envy, inspiration, and enjoyment (e.g., for envy ranging from β = −.44 to β = +.71). The Passive Social Media Use Hypothesis was confirmed for 20% of adolescents and rejected for 80%. More adolescents with browsing-induced envy experienced negative effects on affective well-being (25%) than adolescents with no browsing-induced envy (13%). Conversely, more adolescents with browsing-induced enjoyment experienced positive effects on affective well-being (47%) than adolescents with no browsing-induced enjoyment (9%).
Differential semblance optimisation based on the adaptive quadratic Wasserstein distance
Authors: Yu Zhennan , Liu Yang
Published: August 2021

As the robustness for the wave equation-based inversion methods, wave equation migration velocity analysis (WEMVA) is stable for overcoming the multipathing problem and has become popular in recent years. As a rapidly developed method, differential semblance optimisation (DSO) is convenient to implement and can automatically detect the moveout existing in common image gathers (CIGs). However, by implementing in the image domain with the target of minimising moveouts and improving coherence of the CIGs, the DSO method often suffers from imaging artefacts caused by uneven illumination and irregular observation geometry, which may produce poor velocity updates with artefact contamination. To deal with this issue, in this paper, by introducing Wiener-like filters, we modify the conventional image matching-based objective function to a new one by introducing the quadratic Wasserstein metric technique. The new misfit function measures the distance of two distributions obtained by the convolutional filters and target functions. With the new misfit function, the adjoint sources and the corresponding gradients are improved. We apply the new method to two numerical examples and one field dataset. The corresponding results indicate that the new method is robust to compensate low frequency components of velocity models.
Challenges in the production and use of probiotics as therapeuticals in cancer treatment or prevention
Authors: Mejía-Caballero Alejandra , Salas-Villagrán Vianey Anahi , Jiménez-Serna Alaide , Farrés Amelia
Published: August 2021

Probiotics were defined as microbial strains that confer health benefits to their consumers. The concept has evolved during the last 20 years, and today metabolites produced by the strains, known as postbiotics, and even dead cells, known as paraprobiotics, are closely associated to them. The isolation of commensal strains from human microbiome has led to the development of next generation probiotics. This review aims to present an overview of the developments in the area of cancer prevention and treatment, intimately related to advances in the knowledge of the microbiome role in its genesis and therapy. Strain identification and characterization, production processes, delivery strategies, and clinical evaluation are crucial to translate results into the market with solid scientific support. Examples of recent tools in isolation, strain typification, quality control, and development of new probiotic strains are described. Probiotics market and regulation were originally developed in the food sector, but these new strategies will impact the pharmaceutical and health sectors, requiring new considerations in regulatory frameworks.
The effects of formalin fixation and fluid storage on stable isotopes in rodent hair
Authors: Taylor David , deJesus Elia J , Novak Mark , Terry Rebecca C
Published: August 2021

Stable isotopes are increasingly being used to unlock the wealth of information contained in specimens preserved in museum collections. However, preservation methods that employ formalin may confound ecological interpretations. To quantify the effects of formalin fixation and subsequent fluid storage in ethanol on the isotopic signatures of small mammal hair, we analyzed δ 13C and δ 15N values from specimens of seven rodent species that were sampled repeatedly both before and after varying lengths of formalin fixation (1–11 days) and ethanol storage (1–6 years). We supplemented these data with a 2-week fixation experiment using deer mice (Peromyscus maniculatus) in which no ethanol storage was employed. As expected, preservation in formalin and ethanol had no discernable effect on δ 15N values. In contrast, specimen δ 13C values decreased in a saturating fashion during formalin fixation and over subsequent years of fluid storage in ethanol. On the basis of models that we fit to these time series, we estimate the long-term effect of fixation and storage on δ 13C values to be −0.92‰ after 4 years. This biologically relevant shift in δ 13C values should be accounted for when inferring the diets of species from fluid-stored museum collections and when comparing across specimens with different preservation histories.
Data-driven electron microscopy: electron diffraction imaging of materials structural properties
Authors: Zuo Jian-Min , Yuan Renliang , Shao Yu-Tsun , Hsiao Haw-Wen , Pidaparthy Saran , Hu Yang , Yang Qun , Zhang Jiong
Published: August 2021

Transmission electron diffraction is a powerful and versatile structural probe for the characterization of a broad range of materials, from nanocrystalline thin films to single crystals. With recent developments in fast electron detectors and efficient computer algorithms, it now becomes possible to collect unprecedently large datasets of diffraction patterns (DPs) and process DPs to extract crystallographic information to form images or tomograms based on crystal structural properties, giving rise to data-driven electron microscopy. Critical to this kind of imaging is the type of crystallographic information being collected, which can be achieved with a judicious choice of electron diffraction techniques, and the efficiency and accuracy of DP processing, which requires the development of new algorithms. Here, we review recent progress made in data collection, new algorithms, and automated electron DP analysis. These progresses will be highlighted using application examples in materials research. Future opportunities based on smart sampling and machine learning are also discussed.
Management of SARS-CoV-2 in the Military and Lessons for Future Pandemics
Authors: Yi-Song Liew Terence , Zhi Qiang Seah Benjamin , Chua Choon Guan , Boon Chuan Tan Benjamin
Published: August 2021

Introduction

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in devastating consequences, with high death tolls and significant impact on global health, geopolitics, and socioeconomic aspects of society among others. Militaries around the world have been affected in many ways, in terms of force attrition and disruption to operations.

Materials and Methods

The Republic of Singapore Air Force (RSAF) had formulated multiple strategies and executed several contingency plans to respond swiftly and effectively to the pandemic. Measures taken by the RSAF included leveraging pandemic drawer plans, continuous medical intelligence gathering on SARS-CoV-2 characteristics, conducting rapid disease testing and contact tracing, formulating a risk assessment matrix for personnel based overseas, enforcing safe management measures and mask-wearing, and ensuring that critical medical functions were sustained.

Results

This article summarizes important lessons learnt that may be applied to future pandemics, including the importance of threat assessment, pandemic preparedness, adopting a tiered defense strategy, widespread testing, expeditious contact tracing and isolation, effective communication, and re-defining the new norms for post-pandemic recovery.

Conclusion

The military remains essential to every country’s defense and security. However, its unique construct and nature of operations may render it susceptible to uncontained viral transmission. To minimize manpower attrition and maximize force health in the face of a devastating pandemic, well-thought and tailored management measures must be implemented.
Core formation in high-z massive haloes: heating by post-compaction satellites and response to AGN outflows
Authors: Dekel Avishai , Freundlich Jonathan , Jiang Fangzhou , Lapiner Sharon , Burkert Andreas , Ceverino Daniel , Du Xiaolong , Genzel Reinhard , Primack Joel
Published: August 2021

Observed rotation curves in star-forming galaxies indicate a puzzling dearth of dark matter in extended flat cores within haloes of mass ≥1012M⊙ at z ∼ 2. This is not reproduced by current cosmological simulations, and supernova-driven outflows are not effective in such massive haloes. We address a hybrid scenario where post-compaction merging satellites heat up the dark-matter cusps by dynamical friction, allowing active galactic nucleus (AGN)-driven outflows to generate cores. Using analytic and semi-analytic models (SatGen), we estimate the dynamical friction heating as a function of satellite compactness for a cosmological sequence of mergers. Cosmological simulations (VELA) demonstrate that satellites of initial virial masses >1011.3M⊙, which undergo wet compactions, become sufficiently compact for significant heating. Constituting a major fraction of the accretion on to haloes ≥1012M⊙, these satellites heat up the cusps in half a virial time at z ∼ 2. Using a model for outflow-driven core formation (CuspCore), we demonstrate that the heated dark-matter cusps develop extended cores in response to removal of half the gas mass, while the more compact stellar systems remain intact. The mergers keep the dark matter hot, while the gas supply, fresh and recycled, is sufficient for the AGN outflows. AGNs indeed become effective in haloes ≥1012M⊙, where the black hole growth is no longer suppressed by supernovae and its compaction-driven rapid growth is maintained by a hot circumgalactic medium. For simulations to reproduce the dynamical friction effects, they should resolve the compaction of the massive satellites and avoid artificial tidal disruption. AGN feedback could be boosted by clumpy black hole accretion and clumpy response to AGN.
Resourcing Popular Music for Relevant Themes in Music Therapy with Perinatal Loss
Authors: Mondanaro John
Published: August 2021

Perinatal loss poses unique challenges to grief work because of the complexity of dynamics it carries. Historically shrouded in socially and culturally based belief systems often impeding normal grief responses, the barriers to healthy processing have been surmounted in recent decades. The emergence of music therapy in partnership with social work is one such approach to addressing both anticipatory grief and bereavement of parents enduring the death of their infant prenatally. This retrospective article highlights the resourcing of popular music within a clinical music therapy approach to the curation of a perinatal bereavement event within a large hospital system in a metropolitan area. Popular music as a ubiquitous art form lends tangibility and relevance to the complicated themes of perinatal loss in a manner that invites bereft parents into a forum of acceptance and acknowledgment of a loss that for too long has remained in the shadows.
The CRY2–COP1–HY5–BBX7/8 module regulates blue light-dependent cold acclimation in Arabidopsis
Authors: Li Youping , Shi Yiting , Li Minze , Fu Diyi , Wu Shifeng , Li Jigang , Gong Zhizhong , Liu Hongtao , Yang Shuhua
Published: August 2021

Light and temperature are two key environmental factors that coordinately regulate plant growth and development. Although the mechanisms that integrate signaling mediated by cold and red light have been unraveled, the roles of the blue light photoreceptors cryptochromes in plant responses to cold remain unclear. In this study, we demonstrate that the CRYPTOCHROME2 (CRY2)-COP1-HY5-BBX7/8 module regulates blue light-dependent cold acclimation in Arabidopsis thaliana. We show that phosphorylated forms of CRY2 induced by blue light are stabilized by cold stress and that cold-stabilized CRY2 competes with the transcription factor HY5 to attenuate the HY5–COP1 interaction, thereby allowing HY5 to accumulate at cold temperatures. Furthermore, our data demonstrate that B-BOX DOMAIN PROTEIN7 (BBX7) and BBX8 function as direct HY5 targets that positively regulate freezing tolerance by modulating the expression of a set of cold-responsive genes, which mainly occurs independently of the C-repeat-binding factor pathway. Our study uncovers a mechanistic framework by which CRY2-mediated blue-light signaling enhances freezing tolerance, shedding light on the molecular mechanisms underlying the crosstalk between cold and light signaling pathways in plants.
Reporting of Adverse Events in Randomized Controlled Trials of Therapeutic Exercise for Hip Osteoarthritis: A Systematic Review
Authors: James Khara A , von Heideken Johan , Iversen Maura D
Published: August 2021

Objective

The purpose of this study was to describe adverse events (AEs) and dropouts (DOs) in randomized controlled trials of therapeutic exercise for hip osteoarthritis (HOA) and to identify whether Consolidated Standards of Reporting Trials (CONSORT) guidelines were followed.

Methods

The Cochrane Library, Embase, PubMed, and CINAHL databases were searched. Randomized controlled trials of therapeutic exercise for HOA published in English from January 1, 1980 to August 1, 2020 were included. Studies were excluded if other interventions were provided, if participants had previous hip arthroplasty, or if AEs and DOs for HOA participants were not reported separately. The internal validity of each study (Physiotherapy Evidence Database [PEDro] scoring) was assessed, participant and intervention characteristics were extracted, and the existence of a clear statement and reasons for AEs and DOs was reported. Descriptive statistics characterized results. Data heterogeneity prohibited the use of meta-analysis.

Results

Fourteen studies (mean PEDro score = 7.4; range = 6-10) from 10 countries were included, with 707 participants exercising. Exercise intensity was unspecified in 72.2% of exercise arms. Six studies (42.9%) included a statement of AEs, and 32 AEs were reported. All studies had a DO statement, but 29.0% of DOs occurred for unknown reasons. Six studies (42.9%) gave reasons for DOs that could be classified as AEs in 9 participants; 41 participants (5.8%) experienced exercise-related AEs.

Conclusion

Reports of AEs were inconsistent, some DOs were potentially misclassified, and primary components of exercise interventions were frequently unreported. Despite these limitations, the overall low number of nonserious AEs suggests that the exercise-related risk of harm is minimal for individuals with HOA.

Impact

Understanding the risk of harm associated with exercise for HOA can better inform safe dosing of exercise, clinical implementation, and replicability. Informative, consistent reporting of AEs, DOs, and exercise is needed. Greater use of the CONSORT harms-reporting checklist is warranted.
Effectiveness of a Multicomponent Treatment Based on Pain Neuroscience Education, Therapeutic Exercise, Cognitive Behavioral Therapy, and Mindfulness in Patients With Fibromyalgia (FIBROWALK Study): A Randomized Controlled Trial
Authors: Serrat Mayte , Sanabria-Mazo Juan P , Almirall Míriam , Musté Marta , Feliu-Soler Albert , Méndez-Ulrich Jorge L , Sanz Antoni , Luciano Juan V
Published: August 2021

Objective

The purpose of this study was to evaluate the effectiveness of a 12-week multicomponent treatment based on pain neuroscience education, therapeutic exercise, cognitive behavioral therapy, and mindfulness—in addition to treatment as usual—compared with treatment as usual only in patients with fibromyalgia.

Methods

This randomized controlled trial involved a total of 272 patients who were randomly assigned to either multicomponent treatment (n = 135) or treatment as usual (n = 137). The multicomponent treatment (2-hour weekly sessions) was delivered in groups of 20 participants. Treatment as usual was mainly based on pharmacological treatment according to the predominant symptoms. Data on functional impairment using the Revised Fibromyalgia Impact Questionnaire as the primary outcome were collected as were data for pain, fatigue, kinesiophobia, physical function, anxiety, and depressive symptoms (secondary outcomes) at baseline, 12 weeks, and, for the multicomponent group only, 6 and 9 months. An intention-to-treat approach was used to analyze between-group differences. Baseline differences between responders (>20% Revised Fibromyalgia Impact Questionnaire reduction) and nonresponders also were analyzed, and the number needed to treat was computed.

Results

At posttreatment, significant between-group differences with a large effect size (Cohen d > 0.80) in favor of the multicomponent treatment were found in functional impairment, pain, kinesiophobia, and physical function, whereas differences with a moderate size effect (Cohen d > 0.50 and <0.80) were found in fatigue, anxiety, and depressive symptoms. Nonresponders scored higher on depressive symptoms than responders at baseline. The number needed to treat was 2 (95% CI = 1.7–2.3).

Conclusion

Compared with usual care, there was evidence of short-term (up to 3 months) positive effects of the multicomponent treatment for fibromyalgia. Some methodological shortcomings (eg, absence of follow-up in the control group and monitoring of treatment adherence, potential research allegiance) preclude robust conclusions regarding the proposed multicomponent program.

Impact

Despite some methodological shortcomings in the design of this study, the multicomponent therapy FIBROWALK can be considered a novel and effective treatment for patients with fibromyalgia. Physical therapists should detect patients with clinically relevant depression levels prior to treatment because depression can buffer treatment effects.

Lay Summary

Fibromyalgia is prevalent and can be expensive to treat. This multicomponent treatment could significantly improve the core symptoms of fibromyalgia compared with usual treatment.
Effects of Photobiomodulation Therapy Combined With Exercise in Patients Who Have Chronic Low Back Pain: Protocol for a Randomized Controlled Trial
Authors: dos Santos Flávia Franciele , Braga Morgana Lopes , Barroso Micaelen Mara Ferreira , Oliveira Vinícius Cunha , Oliveira Murilo Xavier
Published: August 2021

Objective

Although commonly prescribed, exercise therapy alone is insufficient for the treatment of low back pain (LBP). Thus, studies recommend a combination of interventions. Photobiomodulation therapy (PBMT) involving low-level laser is an effective intervention for relieving LBP; however, scientific evidence on the effects of laser therapy combined with exercise therapy is scarce and contradictory. The aim of this clinical trial is to evaluate the short-term and long-term effects of the combination of PBMT and an exercise protocol in individuals with persistent nonspecificLBP.

Methods

This 2-armed, randomized, placebo-controlled trial with blinded participants, assessors, and therapists will be conducted in the outpatient physical therapy clinic of a university in Diamantina, Brazil. Participants are 90 individuals between 18 and 65 years of age with self-reported LBP. The participants will be randomly allocated to (1) a 6-week exercise program combined with active PBMT at a frequency of twice per week, totaling 12 sessions (n = 45), or (2) a 6-week exercise program combined with placebo PBMT (n = 45). Clinical outcomes will be measured at baseline as well as at 8 and 20 weeks and 12 months after randomization. The primary outcomes will be pain intensity and disability. The secondary outcomes will be mental health, mobility, disability, and strength of the trunk extensor muscles.

Impact

The findings will help determine whether adding PBMT to a physical therapist–supervised exercise protocol is more effective than the exercise protocol alone for persistent LBP. This study has the potential to guide clinical practice toward innovative ways of providing health care.
“Addiction Doesn’t Discriminate”: Colorblind Racism in American Rehab
Authors: Whetstone Sarah
Published: August 2021

Drawing on ethnography and interviews with recovering men in the Twin Cities, Minnesota, this study explores how two dominant models of American rehab are racialized — coerced treatment theorizing addiction as criminal personality—and a more medicalized, voluntaristic model rooted in the brain disease paradigm. At the “carceral rehab” of “Arcadia House,” staff assumed its majority court-mandated, poor men of color would arrive resistant to reforming their “lifestyle addictions,” justifying treatment backed by (re)incarceration. In contrast, “Healing Bridges” offered its gentler, “medical-restorative rehab” to mostly white, middle-class patients who escaped incarceration despite substantial participation in drug-related crime. While both programs mobilized the colorblind logic that “addiction doesn’t discriminate,” local disparities routed recovering men into vastly different treatments, disproportionately criminalizing the addictions of the Black poor. In a racialized binary operating across the field, Arcadia’s clients of color were viewed as sicker and more out of control than Bridges’ white patients. While Arcadia’s clients required coercive state management, Bridges’ patients were understood as already possessing the capacity for self-management—reinforcing staff’s mission to empower the non-addict within. Distinctions between coerced and voluntary treatment were naturalized and mapped onto recovering men, reproducing race at the most intimate levels of self-making.
Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation
Authors: Ogata Keiko , Liu Yang , Ohara Ayako , Kawamoto Kensuke , Kondo Miwa , Kobayashi Kumiko , Fukuda Takako , Asano Hiroyuki , Kitamoto Sachiko , Lake Brian G , Cohen Samuel M , Yamada Tomoya
Published: August 2021

Permethrin has been shown to increase lung adenomas in female CD-1 mice, but not in male mice or Wistar rats. The proposed mode of action (MOA) for permethrin-induced female mouse lung tumor formation involves morphological changes in Club cells; increased Club cell proliferation; increased Club cell hyperplasia, and lung tumor formation. In this study, the treatment of female CD-1 mice with tumorigenic doses (2500 and 5000 ppm) of permethrin, but not with a nontumorigenic dose (20 ppm), for 14 and/or 28 days increased Club cell replicative DNA synthesis. Global gene expression analysis of female mouse lung samples demonstrated that permethrin treatment up-regulated 3 genes associated with cell proliferation, namely aldehyde dehydrogenase 3a1 (Aldh3a1), oxidative stress-induced growth inhibitor 1, and thioredoxin reductase 1. Treatment with 2500 and 5000 ppm, but not 20 ppm, permethrin for 7 days produced significant increases in mRNA levels of these 3 genes. Immunohistochemical analysis demonstrated that Club cell secretory protein, CYP2F2, and ALDH3A1 colocalized in Club cells; confirmed by flow cytometry analysis of lung cells employing KI67 as a cell proliferation marker. Overall, the present data extend the proposed MOA by demonstrating that Club cells are the primary initial target of permethrin administration in female mouse lungs. As humans are quantitatively much less sensitive to agents that increase Club cell proliferation and lung tumor formation in mice, it is most likely that permethrin could not produce lung tumors in humans. This conclusion is supported by available negative epidemiological data from several studies.
SMRT and Illumina RNA sequencing reveal the complexity of terpenoid biosynthesis in Zanthoxylum armatum
Authors: Liu Xiaomeng , Tang Ning , Xu Feng , Chen Zexiong , Zhang Xian , Ye Jiabao , Liao Yongling , Zhang Weiwei , Kim Soo-Un , Wu Peiyin , Cao Zhengyan
Published: August 2021

Sichuan pepper (Zanthoxylum armatum DC) is a popular spice and is often prescribed in traditional Chinese medicine to treat vomiting, diarrhea, ascariasis and eczema, among other conditions. Volatile oils from Z. armatum leaves contain active ingredients, with terpenoids being one of the main components. In the present study, the combination of sequencing data of Z. armatum from PacBio single molecule real time (SMRT) and Illumina RNA sequencing (RNA-Seq) platforms facilitated an understanding of the gene regulatory network of terpenoid biosynthesis in pepper leaves. The leaves of three developmental stages from two Z. armatum cultivars, ‘Rongchangwuci’ (WC) and ‘Zhuye’ (ZY), were selected as test materials to construct sequencing libraries. A total of 143,122 predictions of unique coding sequences, 105,465 simple sequence repeats, 20,145 transcription factors and 4719 long non-coding RNAs (lncRNAs) were identified, and 142,829 transcripts were successfully annotated. The occurrence of alternative splicing events was verified by reverse transcription PCR, and quantitative real-time PCR was used to confirm the expression pattern of six randomly selected lncRNAs. A total of 96,931 differentially expressed genes were filtered from different samples. According to functional annotation, a total of 560 candidate genes were involved in terpenoid synthesis, of which 526 were differentially expressed genes (DEGs). To identify the key genes involved in terpenoid biosynthesis, the module genes in different samples, including structural and transcription factors genes, were analyzed using the weighted gene co-expression network method, and the co-expression network of genes was constructed. Thirty-one terpenoids were identified by gas chromatography–mass spectrometry. The correlation between 18 compounds with significantly different contents and genes with high connectivity in the module was jointly analyzed in both cultivars, yielding 12 candidate DEGs presumably involved in the regulation of terpenoid biosynthesis. Our findings showed that full-length transcriptome SMRT and Illumina RNA-Seq can play an important role in studying organisms without reference genomes and elucidating the gene regulation of a biosynthetic pathway.
XVIII Bibliography, Textual Criticism, and Reference Works
Authors: Baker William
Published: August 2021

Owing to Covid-19 and its impact on the supplies of review copies to reviewers, this chapter covering 2019 publications is longer than usual. Thanks are due to Professor Brent E. Kinser, James May, Albert Pionke, Patrick Scott, Shef Rogers, and to our Associate Editors for letting me know what their contributors have been unable to include. It is divided into five sections, and contents may overlap: 1. Periodicals; 2. Editions; 3. Bibliography and Associated Books and Articles; 4. History and Companions; 5. Shakespeare, History of Libraries, Collections, and Miscellaneous including Reference Materials
Macrophage migration inhibitory factor of Thelazia callipaeda induces M2‐like macrophage polarization through TLR4‐mediated activation of the PI3K‐Akt pathway
Authors: Cai Juan , Huang Lin , Tang Hongri , Xu Hongling , Wang Lingjun , Zheng Minghui , Yu Hongsong , Liu Hui
Published: August 2021

Macrophage migration inhibitory factor (MIF), an immunoregulatory cytokine plays an important role in inflammation and the immune response, and has been described as having a potential role in immune evasion by parasites. Thelazia callipaeda, a vector‐borne zoonotic eye worm with a broad host range, has been documented as an agent of ocular infection of thelaziosis. The ability of T. callipaeda to persist in an immunologically competent host has led to the suggestion that it has evolved specific measures to counter immune defenses. To date, whether the immune evasion of T. callipaeda is related to MIF and the possible related signaling pathway and molecular mechanism have remained unclear. In the present study, we examined the effect of T. callipaeda MIF (T. cp‐MIF) on macrophages. We analyzed the antigenic epitopes of the candidate T. cp‐MIF and found that it exhibited an ideal antigenic index. Morphology, Flow cytometry, and cytokine analysis showed that T. cp‐MIF induced the dynamic polarization of THP‐1 macrophages from the M1‐like phenotype to the M2‐like phenotype. The chemotaxis assay revealed an inhibitory effect of T. cp‐MIF on THP‐1 macrophages. Western blotting suggested that, compared to the control, THP‐1 macrophages exposed to T. cp‐MIF had higher TLR4 protein expression and the phosphatidylinositol 3′‐kinase (PI3K) ‐Akt pathway activation. In conclusion, T. cp‐MIF induces M2‐like macrophage polarization through TLR4‐mediated activation of the PI3K‐Akt pathway, which might provide a basis for future research on how it affects the immune system of the host.
Effectiveness of Semiocclusive Sodium Carboxymethyl Cellulose Fibers and Hydrocolloid Dressings for Irritant Peristomal Dermatitis: A Case Series
Authors: Collado-Boira Eladio , Boldo-Roda Pilar , Bernat-Adell María Desamparados , Morar Kavita Gandhi , Ayora Ana Folch , Medina Pablo Salas
Published: August 2021

The most common complication in individuals with ostomies is irritant contact dermatitis from the acidic stoma effluent coming into contact with the peristomal skin. Although protective powders are widely used for the treatment of peristomal skin, there is little scientific evidence to justify their use. The combined use of sodium carboxymethylcellulose cellulose fibers (SCCFs) together with a hydrocolloid dressing for fixation is an effective alternative in the management of these wounds. Here, the authors report a case series of three patients presenting at a stoma therapy clinic with peristomal skin lesions because of severe irritant contact dermatitis. Patients were men aged between 70 and 81 years, had been diagnosed with colon cancer (n = 2) or bladder cancer (n = 1), and had undergone a colostomy (n = 1), ileostomy (n = 1), or Bricker-type ureteroileostomy (n = 1). A semiocclusive care protocol was applied in a moist environment using SCCF and an extrathin hydrocolloid adhesive dressing, and the collection device was secured using adhesive resin and an ostomy belt. The combined use of SCCF and hydrocolloid dressings provided beneficial results to treat the dermatitis, with reduced discomfort after 7 days and lesions healing within 4 weeks.
Protective Dressings, Injury, and Device Failure in Preterm Infants Receiving Nasal Continuous Positive Airway Pressure: A Randomized Controlled Trial
Authors: Rezaei Parvane , Jafari-Mianaei Soheila , Sadeghnia Alireza , Heidari Zahra
Published: August 2021

OBJECTIVE

To investigate the protective effect of a hydrocolloid nasal dressing on the incidence and severity of nasal injury and continuous positive airway pressure (CPAP) failure in preterm infants receiving nasal CPAP (N-CPAP).

METHODS

A randomized controlled trial was conducted over 4 months in 2019 at level 3 neonatal ICUs in two hospitals affiliated with Isfahan University of Medical Sciences, Iran. Eighty eligible infants were born at 32 weeks of gestation or younger and/or with a birth weight of 1,500 g or less and had received between 4 and 72 hours of CPAP. Infants were randomly assigned to two groups; the intervention group used a protective dressing, and the control group received routine care. Data collection tools included a demographic questionnaire and nasal injury assessment score chart.

MAIN OUTCOME MEASURES

The incidence and severity of nasal injury in preterm infants undergoing N-CPAP.

RESULTS

Infants in the intervention group had a significantly lower incidence and severity of nasal injury compared with the control group: 15 of 40 (37.5%) versus 37 of 40 (92.5%; P < .001). Overall, the injuries identified in this study were mostly mild and moderate, with only three severe injuries in the intervention group and five in the control group. No significant differences were detected in CPAP failure (P > .05).

CONCLUSIONS

The studied nasal barrier dressing is a safe and convenient solution to reduce nasal injury in preterm infants receiving N-CPAP.
Vacuum-Assisted Therapy for Combined Volar-Dorsal Soft-Tissue Defects of the Hand: A Case Report
Authors: Klein David S. , Yingling John M. , Patel Priya , Capo John T.
Published: August 2021

Application of negative-pressure wound therapy dressings to the web spaces and small, often moist, areas of the hand can be technically demanding and time consuming. The researchers present a case report and technique for managing a devastating hand infection and soft-tissue defects by creating a self-fabricated sponge glove that is easily reproducible. Vacuum-assisted therapy for combined volar dorsal soft-tissue defects of the hand, or “Hand Vac,” is a novel approach for treating extensive hand wounds. This technique was used in a patient with diabetes with a deep space infection of the hand following serial debridements and antibiotic bead therapy. A single, medium-size sponge was cut using a knife and scissors to create an easily applied glove that was then sealed with adhesive dressing and a single suction port. The patient avoided complete amputation of the hand and deep infection was eradicated. The wounds had progressive granulation and healing and were eventually covered with split-thickness skin grafts. The authors conclude that severe soft-tissue defects involving both the volar and dorsal aspects of the hand can be effectively managed with a single glove-like sponge and suction port.
Evolution in the Acute Management of Open Fracture Treatment? Part 1
Authors: Sagi Henry C. , Patzakis Michael J.
Published: August 2021

Introduction:

Despite decades of advancement in wound debridement, prophylactic antibiotic therapy, fracture stabilization, and soft tissue reconstruction, infection remains a serious complication after open fracture. Inconclusive historical data and new challenges with resistant organisms and antimicrobial stewardship having created a difficult environment within which to develop sound, evidence-based treatment protocols that can be applied universally. The first part of this 2-part series will synthesize the historical perspective along with the current concepts surrounding bacteriology and antibiotic use/stewardship. Part 2 will analyze and summarize the current literature regarding the management of open fracture and prevention of subsequent infection.

Numerous authors from Hippocrates to Larrey noted that superior results were obtained with an early aggressive debridement of necrotic tissue after wounding.
1–7
Historically, the usual outcome after open fracture was infection, sepsis, amputation, and death before the introduction of antibiotics.
8–11
As recently as the first half of the 20th century, surgeons argued that if an appropriate debridement was performed, antibiotics were not necessary and advocated against their routine use over concern for resistant organisms.

The current period of open fracture treatment (starting in the 1970s) heralded a more scientific era with critical evaluation of antibiotics, surgical debridement, and the development of standardized evidence-based protocols. This era began with 3 classic articles by Patzakis and Gustilo that, to this day, remain central to the discussion of infection prevention after open fractures.
12–14

Level of Evidence:

Therapeutic Level V. See Instructions for Authors for a Complete description of levels of evidence.
Radiography of the Distal Radius
Authors: Gray Robert R. L. , Foremny Gregory , Lee Susan , Greditzer Tate
Published: August 2021

Imaging of the distal radius is of paramount importance in diagnosing injuries, indicating patients for operative or nonoperative treatment, and appropriately following patients for associated injuries and complications. Plain radiographs and fluoroscopy are the dominant imaging modalities in all settings because they are readily available and provide valuable information about the osseous structures and any instrumentation. Computed tomography can offer more information about implant placement and the level of comminution of the articular surfaces but is more expensive and exposes patients to higher doses of radiation. Magnetic resonance imaging is less commonly used but is useful for occult fractures and other associated injuries. Ultrasonography is gaining popularity in evaluating implant placement, especially regarding tendon impingement and subsequent tendon injury.
Improving Timeliness of Antibiotic Administration Using a Provider and Pharmacist Facing Sepsis Early Warning System in the Emergency Department Setting: A Randomized Controlled Quality Improvement Initiative*
Authors: Tarabichi Yasir , Cheng Aurelia , Bar-Shain David , McCrate Brian M. , Reese Lewis H. , Emerman Charles , Siff Jonathan , Wang Christine , Kaelber David C. , Watts Brook , Hecker Michelle T.
Published: August 2021

OBJECTIVES:

Results of pre-post intervention studies of sepsis early warning systems have been mixed, and randomized clinical trials showing efficacy in the emergency department setting are lacking. Additionally, early warning systems can be resource-intensive and may cause unintended consequences such as antibiotic or IV fluid overuse. We assessed the impact of a pharmacist and provider facing sepsis early warning systems on timeliness of antibiotic administration and sepsis-related clinical outcomes in our setting.

DESIGN:

A randomized, controlled quality improvement initiative.

SETTING:

The main emergency department of an academic, safety-net healthcare system from August to December 2019.

PATIENTS:

Adults presenting to the emergency department.

INTERVENTION:

Patients were randomized to standard sepsis care or standard care augmented by the display of a sepsis early warning system–triggered flag in the electronic health record combined with electronic health record–based emergency department pharmacist notification.

MEASUREMENTS AND MAIN RESULTS:

The primary process measure was time to antibiotic administration from arrival. A total of 598 patients were included in the study over a 5-month period (285 in the intervention group and 313 in the standard care group). Time to antibiotic administration from emergency department arrival was shorter in the augmented care group than that in the standard care group (median, 2.3 hr [interquartile range, 1.4–4.7 hr] vs 3.0 hr [interquartile range, 1.6–5.5 hr]; p = 0.039). The hierarchical composite clinical outcome measure of days alive and out of hospital at 28 days was greater in the augmented care group than that in the standard care group (median, 24.1 vs 22.5 d; p = 0.011). Rates of fluid resuscitation and antibiotic utilization did not differ.

CONCLUSIONS:

In this single-center randomized quality improvement initiative, the display of an electronic health record–based sepsis early warning system–triggered flag combined with electronic health record–based pharmacist notification was associated with shorter time to antibiotic administration without an increase in undesirable or potentially harmful clinical interventions.
Antidepressant Discontinuation
Authors: Vinkers Christiaan H. , Ruhé Henricus G. , Penninx Brenda W.
Published: August 2021

Background

The topic of patients’ discontinuing use of antidepressants has received increasing attention. Patients and physicians can encounter challenges regarding the three major questions in the field of antidepressant discontinuation: who can discontinue, what is the best time to discontinue; and what is the best method to discontinue.

Methods

This commentary summarizes the current state of the evidence related to antidepressant discontinuation.

Results

There is limited evidence underlying the extremely relevant clinical topic of antidepressant discontinuation. It is poorly understood which patients, after response to antidepressants, benefit (most) from discontinuation. Moreover, established and validated markers of an individual’s risk of relapse after antidepressant cessation are lacking, and non-sponsored discontinuation studies are rare. Many discontinuation studies do not distinguish between relapse and antidepressant discontinuation symptoms, and very few studies compared different discontinuation strategies, with none of the compared strategies exceeding 2 weeks of tapering. Finally, blinding of discontinuation strategies is often insufficient to properly address placebo and nocebo aspects, whereas the pharmacological characteristics of different antidepressants in relation to discontinuation have hardly been studied.

Conclusions

Antidepressant discontinuation is a clinically relevant topic. There is a strong need for more robust evidence to indicate who can discontinue antidepressants, when and in which manner (how). Blinded randomized controlled trials are pivotal to optimally advise physicians, patients and policy-makers. This scientific knowledge can guide evidence-based decision making in clinical practice.
Cancer Incidence and Mortality Among Fighter Aviators in the United States Air Force
Authors: Webber Bryant J. , Tacke Crystal D. , Wolff Gregory G. , Rutherford Ashley E. , Erwin William J. , Escobar James D. , Simon Alisa A. , Reed Brian H. , Whitaker Justin G. , Gambino-Shirley Kelly J. , Stuever David M.
Published: August 2021

Objective:

This study sought to clarify cancer risk in fighter aviators.

Methods:

US Air Force officers who served between 1970 and 2004 were followed through 2018 for incidence and mortality of 10 cancers: colon and rectum; pancreas; melanoma skin; prostate; testis; urinary bladder; kidney and renal pelvis; brain and other nervous system; thyroid; and non-Hodgkin lymphoma. Fighter aviators were compared with other officers and the general US population.

Results:

Compared with other officers, male fighter aviators had greater adjusted odds of developing testis, melanoma skin, and prostate cancers; mortality odds were similar for all cancers. When compared with the US population, male fighter aviators were more likely to develop and die from melanoma skin cancer, prostate cancer, and non-Hodgkin lymphoma.

Conclusions:

Military fighter aviation may be associated with slightly increased risk of certain cancers.
Impact of Medication Adherence on Healthcare Resource Utilization, Work Loss, and Associated Costs in a Privately Insured Employed Population Treated With Adalimumab in the United States
Authors: Mittal Manish , Yang Min , Shah Manan , Gao Wei , Carley Christopher , Sherman Bruce W.
Published: August 2021

Objective:

The aim of this study was to evaluate the impact of adherence to adalimumab on all-cause work loss, healthcare resource utilization (HRU), and direct medical and indirect costs over 2 years using real-world data.

Methods:

This was a retrospective cohort study using a large, United States administrative claims database. Adult patients treated with adalimumab were grouped into adherent and non-adherent cohorts and followed for up to 2 years. Outcomes were compared between cohorts.

Results:

Over 2 years, adherent patients had $10,214 lower per patient medical and indirect costs compared to non-adherent patients, resulting from lower HRU, fewer days of absenteeism, and lower rates of work loss events.

Conclusion:

Patient and societal benefits of adherence to adalimumab are significant over 2 years. These findings highlight the importance of policies aimed at improving adherence to self-administrated medications.
Retrospective Longitudinal Evaluation of Male Firefighter's Body Composition and Cardiovascular Health
Authors: Bond Colin W. , Waletzko Stephanie P. , Reed Valerie , Glasner Ellie , Noonan Benjamin C.
Published: August 2021

Objective:

Describe firefighter body composition and cardiovascular health as a function of age.

Methods:

217 male firefighters with 1922 distinct evaluations over 23-years were included in this retrospective analysis. The firefighters had their height, mass, six-site skin-fold, blood pressure, and resting heart rate measured annually. Linear mixed models were used to analyze the effect of age. Significance was set to P < 0.05.

Results:

With each 1-year increase in age, mass (0.42 kg, P < 0.001), body mass index (0.13 kg m−2, P < 0.001), body fat percentage (0.18%, P < 0.001), fat mass (0.25 kg, P < 0.001), and fat free mass (0.15 kg, P < 0.001) increased. Systolic blood pressure (−0.09 mm Hg, P = 0.263), diastolic blood pressure (0.05 mm Hg, P = 0.308), and resting heart rate (0.07 beats min−1, P = 0.291) did not change.

Conclusions:

Interventions to maintain healthy body composition are critical to reduce sudden cardiovascular related death risk.
Expression of ANCR in nasopharyngeal carcinoma patients and its clinical significance
Authors: Guo Chengbing , Ma Xingkai , He Hailin , Li Yanhua , Zhou Jieyu
Published: August 2021

Anti-differentiation non-coding RNA (ANCR), a long non-coding RNA, is involved in the development, progression and metastasis of various human cancers. However, its clinical significance in nasopharyngeal carcinoma (NPC) still remains unknown. This study aimed to investigate ANCR expression and its clinical significance in NPC.

Totally, 96 NPC tissues and 24 non-cancerous nasopharyngeal mucosa tissues were used. The levels of ANCR were determined by qRT-PCR. Relationship of ANCR with patient clinical characteristics, disease-free survival and overall survival (OS) was evaluated.

ANCR expression was increased in NPC tissues compared to non-cancerous nasopharyngeal mucosae. ANCR expression was significantly related to lymph node metastasis, clinical stage, and tumor differentiation (P < .05). Kaplan-Meier survival analysis revealed that high level of ANCR expression was significantly associated with poor disease-free survival but not with OS in NPC patients. Univariate analysis showed a significant association between increased ANCR expression and adverse OS (P < .05), but multivariate analysis suggested that ANCR could not be used as an independent prognostic factor for NPC patients.

ANCR is involved in the development and progression of NPC, but whether it can be used as an effective therapeutic target for NPC needs further study.