bluuebunny/crossref_metadata_2025 huggingface dataset:
A Complex Phenotype of a Patient with Spastic Paraplegia Type 4 Caused by a Novel Pathogenic Variant in the SPAST Gene
Authors: Akaba Yuichi , Takeguchi Ryo , Tanaka Ryosuke , Takahashi Satoru
Published: December 2021

Hereditary spastic paraplegias (HSPs) are rare neurological disorders caused by degeneration of the corticospinal tract. Among the 79 causative genes involved in HSPs, variants in SPAST on chromosome 2p22, which encodes the microtubule-severing protein spastin, are responsible for spastic paraplegia type 4 (SPG4), the most common form of HSPs. SPG4 is characterized by a clinically pure phenotype that is associated with restricted involvement of the corticospinal tract; however, it is often accompanied by additional neurological symptoms such as epilepsy and cognitive impairment. There are few reports regarding the clinical course and treatment of epilepsy associated with SPG4. We describe a 21-year-old male patient with progressive weakness and spasticity of the lower limbs since infancy, which was complicated by epilepsy and cognitive impairment. Magnetic resonance imaging of the brain showed right hippocampal atrophy before the onset of epilepsy. Genetic analysis revealed a novel missense variant (NM_014946.4:c.1330G>C, p.Asp444His) in the SPAST gene. At the age of 13, the patient developed focal epilepsy, characterized by focal onset seizures that were preceded by a sensation of chest tightness. Carbamazepine, levetiracetam, and zonisamide were ineffective in controlling the seizures; however, the use of lacosamide in combination with lamotrigine and valproate was highly effective in improving the seizure symptoms and led to the patient being seizure free for at least 2 years. In conclusion, the missense variant in SPAST may cause a complex SPG4 phenotype accompanied by epilepsy and cognitive impairment, suggesting that the clinical manifestations of this condition do not confine to the motor system.
Being a Cancer Patient during the Time of COVID-19: Impact of the Pandemic on the Anxiety and the Sleeping Quality of Oncology Patients
Authors: Güç Zeynep Gülsüm , Alacacıoğlu Ahmet , Yazır Merve Güleç , Kalender Mehmet Eren , Ünal Sinan , Oflazoğlu Utku , Yıldız Yaşar , Salman Tarık , Küçükzeybek Yüksel , Ellidokuz Hülya , Tarhan Mustafa Oktay
Published: December 2021

Objective: In this study, we aimed to assess anxiety and sleep quality in cancer patients treated or followed up at our clinic at the time of the outbreak of the COVID-19 pandemic. Methods: Seven hundred and sixty-one patients who were either treated or followed up at our oncology clinic between April 2020 and May 2020 were included. Patients were assessed with the State-Trait Anxiety Inventory (STAI) and the Pittsburgh Sleep Quality Index (PSQI). Results: Mean scores of the 761 participants were STAI, 43.45 ± 9.34 (range, 23–75), and PSQI, 5.67 ± 4.24 (range, 0–19). Quality of sleep was found bad in 447 (58.7%) (global score ≥5). Univariate analyses demonstrated statistical differences by stage of cancer, status of treatment, subgroup of treatment, monthly income, and levels of education in anxiety and sleep quality levels. Multivariate analyses showed active treatment (OR: 21.4; 95% CI: 9.08–50.4; p < 0.001) as the major independent variable that affected sleep quality; the major independent variable associated with anxiety was low income (OR: 4.43; 95% CI: 1.69–11.5; p = 0.002). Conclusion: Anxiety and sleep quality levels were found comparable to pre-pandemic reports, and the pandemic was not observed to have additional negative impact on cancer patients. Also, universal basal anxiety and sleep disorder that accompany cancer or active treatment were observed in our study. The accurate effects of the pandemic can be analyzed in further studies using repeated data obtained from the same patient group.
Newly Developed Psoriasis in a Patient with Telangiectasia Macularis Eruptiva Perstans and Systemic Mastocytosis Treated with Interferon
Authors: Péčová Tatiana , Burjanivová Tatiana , Malicherová Bibiana , Péč Martin Jozef , Rohoň Igor , Madleňák Matúš , Adamicová Katarína , Péč Juraj
Published: December 2021

The authors present a rare case of a patient with telangiectasia macular eruptiva perstans, with confirmed D816V mutation which later progressed to systemic mastocytosis confirmed by trepanobiopsy. First-line treatment – phototherapy – had to be stopped, and systemic treatment with interferon alpha-2a was initiated. The treatment was successful with regression of skin lesions as well as mast cell infiltrates in the bone marrow. However, the treatment was complicated by the onset of psoriasis lesions.
Severe Acute Respiratory Syndrome Corona Virus-2 Infection in a Pediatric Kidney Transplant Recipient: A Case Report from India
Authors: Tatapudi Ravi Raju , Kopparti Venkateswara Rao , Poosapati Anusha , Metta Srinivas , Palli Vedita , Vedulla Balakrishna
Published: December 2021

COVID-19 pandemic affected millions of people across India. COVID-19 cases are fewer in children with less severity and better outcomes than in adults. However, a small proportion develop severe illness and succumb to the disease. Clinical manifestations and optimal management of COVID-19 in immunocompromised children are not clearly known. Remdesivir was shown to be efficient in reducing the recovery time in COVID-19 patients requiring supplemental oxygen. Remdesivir is approved for use in children with severe COVID-19, but there are no guidelines in patients with risk factors like recent solid organ transplantation. We report a case of a 10-year-old kidney transplant recipient (KTR) infected with severe acute respiratory syndrome corona virus-2, 2.5 months after the transplantation. Unlike most children, he presented with high fever, cough, and vomiting. His inflammatory markers were elevated. In this case report, we discussed management and clinical outcomes of this patient. In view of recent kidney transplantation and the severity of infection with emergent oxygen requirement, we gave him remdesivir. We continued prednisolone and tacrolimus and stopped mycophenolate. He recovered completely in 7 days. We feel that severely immunosuppressed KTR children with COVID-19 will benefit with remdesivir administration. Monitoring tacrolimus trough levels is essential for maintaining adequate immunosuppression.
Prevention of Incisional Hernia after Open Hepato-Pancreato-Biliary Surgery: A Systematic Review
Authors: Memba Robert , Morató Olga , Estalella Laia , Pavel Mihai C. , Llàcer-Millán Erik , Achalandabaso Mar , Julià Elisabet , Padilla Erlinda , Olona Carles , O’Connor Donal , Jorba Rosa
Published: December 2021

Introduction: Most hepato-pancreato-biliary (HPB) procedures are still performed through open approach. Incisional hernia (IH) is one of the most common complications after open surgery. To date, published data on IH after HPB surgery are scarce; therefore, the aim of this study was to assess the current evidence regarding incidence, risk factors, and prevention. Methods: Medline/PubMed (1946–2020), EMBASE (1947–2020), and the Cochrane library (1995–2020) were searched for studies on IH in open HPB surgery. Animal studies, editorials, letters, reviews, comments, short case series and liver transplant, laparoscopic, or robotic procedures were excluded. The protocol was registered with PROSPERO (CRD42020163296). Results: A total of 5,079 articles were retrieved. Eight studies were finally included for the analysis. The incidence of IH after HPB surgery ranges from 7.7% to 38.8%. The identified risk factors were body mass index, surgical site infection, ascites, Mercedes or reversed T incisions, and previous IH. Prophylactic mesh might be safe and effective. Conclusions: IH after open HPB surgery is still an important matter. Some of the risk factors are specific for the HPB operations and the incision type should be carefully considered. Randomized controlled trials are required to confirm the role of prophylactic mesh after HPB operations.
Post-Progression Treatments after Palbociclib plus Endocrine Therapy in HR+/HER2– Metastatic Breast Cancer Patients: What Is the Better Choice?
Authors: Fabi Alessandra , Ciccarese Mariangela , Scagnoli Sinome , Russillo Michelangelo , Schettini Francesco , Buono Giuseppe , Lorusso Vito , Cannita Katia , Arpino Grazia , Stani Simonetta , Palleschi Michela , Rossello Rosalba , Sarobba Giuseppina , Fabbri Agnese , Giampaglia Marianna , Pellegrini Patrizia , Adamo Vincenzo , Morelli Francesca , Barberi Vittoria , Ferretti Gianluigi , Catania Giovanna , Pisegna Simona , Cognetti Francesco , Giannarelli Diana
Published: December 2021

Background: To date, a consensus has not yet been reached about the therapy sequence after disease progression (PD) on CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer (MBC).
Objectives: The present study assesses, in a real-world setting, the activity of different subsequent therapies in patients who experienced a PD on palbociclib (P) + endocrine therapy (ET), to evaluate the best therapy sequence.
Methods: This is a multicenter retrospective observational study. Records of consecutive HR+/HER2- MBC patients from January 2017 to May 2019 were reviewed. The primary endpoint was the evaluation of progression-free survival (PFS) according to subsequent treatment lines after progression on P+ET. Toxicity data were also collected.
Results: The outcomes were analyzed in 89 MBC patients that had progressed on previous P+ET: 17 patients were on hormone therapy (HT) and 31 patients on chemotherapy (CT) as second-line treatments; seven patients were on HT and 34 on CT as third-line therapies. PFS of patients treated with HT as second-line therapy is significantly improved when compared with patients treated with CT (p=0.01). Considering third-line settings, the difference in PFS was not statistically different between HT and CT. A better outcome in terms of toxicity is observed among HT patients for both second- and third-line therapies.
Conclusions: patients who were progressive on P+ET could still benefit from a subsequent ET. In patients who experienced a good efficacy from prior ET, without visceral metastatic sites, HT seems the most suitable option, when compared to CT, also in terms of safety.
NPPA Promoter Hypomethylation Predicts Central Obesity Development: A Prospective Longitudinal Study in Chinese Adults
Authors: Li Jing , Zhu Jinhua , Zhang Qiu , Chen Linan , Ma Shengqi , Lu Ying , Shen Bin , Zhang Rongyan , Zhang Mingzhi , He Yan , Wu Lei , Peng Hao
Published: December 2021

Introduction: Atrial natriuretic peptide plays a potential role in obesity with unclear molecular mechanisms. The objective of this study was to examine the association between its coding gene (natriuretic peptide A [NPPA]) methylation and obesity. Methods: Peripheral blood DNA methylation of NPPA promoter was quantified at baseline by targeted bisulfite sequencing for 2,497 community members (mean aged 53 years, 38% men) in the Gusu cohort. Obesity was repeatedly assessed by body mass index (BMI) and waist circumference (WC) at baseline and follow-up examinations. The cross-sectional, longitudinal, and prospective associations between NPPA promoter methylation and obesity were examined. Results: Of the 9 CpG loci assayed, DNA methylation levels at 6 CpGs were significantly lower in participants with central obesity than those without (all p < 0.05 for permutation test). These CpG methylation levels at baseline were also inversely associated with dynamic changes in BMI or WC during follow-up (all p < 0.05 for permutation test). After an average 4 years of follow-up, hypermethylation at the 6 CpGs (CpG2 located at Chr1:11908348, CpG3 located at Chr1:11908299, CpG4 located at Chr1:11908200, CpG5 located at Chr1:11908182, CpG6 located at Chr1:11908178, and CpG8 located at Chr1:11908165) was significantly associated with a lower risk of incident central obesity (all p < 0.05 for permutation test). Conclusions: Hypomethylation at NPPA promoter was associated with increased future risk of central obesity in Chinese adults. Aberrant DNA methylation of the NPPA gene may participate in the mechanisms of central obesity.
Famine and Trajectories of Body Mass Index, Waist Circumference, and Blood Pressure in Two Generations: Results From the CHNS From 1993–2015
Authors: Li Jie , Yang Qingling , An Ran , Sesso Howard D. , Zhong Victor W. , Chan Kei Hang Katie , Madsen Tracy E. , Papandonatos George D. , Zheng Tongzhang , Wu Wen-Chih , Song Yan , Yu Xueqing , Liu Simin
Published: December 2021

Background:

Early-life exposures play key roles in the development of metabolic diseases. Whether such effects exist beyond one generation remains unclear. This study aimed to determine the transgenerational association of early-life exposure to the Chinese famine of 1959 to 1962 with the trajectories of body mass index (BMI), waist circumference (WC), and blood pressure (BP) in 2 consecutive generations.

Methods:

We included 21 106 F1 observations born between 1954 and 1967 (median age: 45 years) and 1926 F2 observations (median age: 23 years) from the longitudinal household-based China Health and Nutrition Survey from 1993 to 2015. Trajectories of BMI, WC, systolic BP, and diastolic BP were fitted and compared between groups using linear mixed effect models.

Results:

Early-life exposure to famine was associated with increased BMI, WC, and BP in 2 consecutive generations with sex and age disparities. In F1, famine was associated with increased BMI, WC, systolic BP, and diastolic BP, especially in men or those aged older than 50 years (
P
ranged from <0.001 to 0.02). In F2 men but not women, the parental exposure to famine was associated with 0.59 kg/m
2
([95% CI, 0.10–1.08],
P
=0.02) increase in BMI. In F2 aged ≥25 years but not those younger ones, the parental exposure to famine was associated with increased BMI (0.83 kg/m
2
[0.14–1.51],
P
=0.03), systolic BP (2.04 mm Hg [0.20–3.88],
P
=0.03), and diastolic BP (1.73 mm Hg [0.28–3.18],
P
=0.02).

Conclusions:

The effects of an adverse developmental environment through famine in early life on BMI and BP later in life may persist beyond one generation.
Abuse in Childhood and Cardiometabolic Health in Early Adulthood: Evidence From the Avon Longitudinal Study of Parents and Children
Authors: Goncalves Soares Ana , Zimmerman Annie , Zammit Stan , Karl Anke , Halligan Sarah L. , Fraser Abigail
Published: December 2021

Background

Although childhood abuse has been consistently associated with cardiovascular disease in later adulthood, its associations with cardiometabolic health in younger adults are poorly understood. We assessed associations between childhood physical, sexual, and psychological abuse and cardiometabolic outcomes at 18 and 25 years.

Methods and Results

We used data on 3223 participants of the ALSPAC (Avon Longitudinal Study of Parents and Children). Exposure to childhood abuse was self‐reported retrospectively at 22 years. We used linear regression to assess the associations between childhood abuse and cardiometabolic outcomes at 18 and 25 years. At 18 years, physical (β 1.35 kg/m
2
; 95% CI, 0.66–2.05), sexual (β 0.57 kg/m
2
; 95% CI 0.04–1.11), and psychological (β 0.47 kg/m
2
; 95% CI 0.01–0.92) abuse were associated with higher body mass index. Physical abuse was also associated with lower high‐density lipoprotein cholesterol (β −0.07 mmol/L; 95% CI, −0.13 to −0.01) and higher C‐reactive protein (31%; 95% CI, 1%–69%), and sexual abuse was associated with higher heart rate (β 1.92 bpm; 95% CI 0.26–3.58). At age 25, all 3 types of abuse were additionally associated with higher insulin, and sexual abuse was associated with lower cholesterol (−0.14 mmol/L; 95% CI, −0.26 to −0.01). The age at which abuse occurred (<11or 11–17 years) had little influence on the associations, and when sex differences were evident, associations were stronger in men.

Conclusions

Childhood abuse is associated with negative cardiometabolic outcomes even by young adulthood. Further follow‐up will determine whether associations strengthen across the life course and whether sex differences persist, which is essential for targeting effective screening programs and early interventions in those who suffered abuse in childhood.
Noninvasive Scale Measurement of Stroke Volume and Cardiac Output Compared With the Direct Fick Method: A Feasibility Study
Authors: Yazdi Daniel , Sridaran Suriya , Smith Sarah , Centen Corey , Patel Sarin , Wilson Evan , Gillon Leah , Kapur Sunil , Tracy Julie A. , Lewine Katherine , Systrom David M. , MacRae Calum A.
Published: December 2021

Background

Objective markers of cardiac function are limited in the outpatient setting and may be beneficial for monitoring patients with chronic cardiac conditions. We assess the accuracy of a scale, with the ability to capture ballistocardiography, electrocardiography, and impedance plethysmography signals from a patient’s feet while standing on the scale, in measuring stroke volume and cardiac output compared with the gold‐standard direct Fick method.

Methods and Results

Thirty‐two patients with unexplained dyspnea undergoing level 3 invasive cardiopulmonary exercise test at a tertiary medical center were included in the final analysis. We obtained scale and direct Fick measurements of stroke volume and cardiac output before and immediately after invasive cardiopulmonary exercise test. Stroke volume and cardiac output from a cardiac scale and the direct Fick method correlated with
r
=0.81 and
r
=0.85, respectively (
P
<0.001 each). The mean absolute error of the scale estimated stroke volume was −1.58 mL, with a 95% limits of agreement of −21.97 to 18.81 mL. The mean error for the scale estimated cardiac output was −0.31 L/min, with a 95% limits of agreement of −2.62 to 2.00 L/min. The changes in stroke volume and cardiac output before and after exercise were 78.9% and 96.7% concordant, respectively, between the 2 measuring methods.

Conclusions

In a proof‐of‐concept study, this novel scale with cardiac monitoring abilities may allow for noninvasive, longitudinal measures of cardiac function. Using the widely accepted form factor of a bathroom scale, this method of monitoring can be easily integrated into a patient’s lifestyle.
Coronary Artery Disease Events and Carotid Intima‐Media Thickness in Type 1 Diabetes in the DCCT/EDIC Cohort
Authors: Polak Joseph F. , Backlund Jye‐Yu C. , Budoff Matt , Raskin Philip , Bebu Ionut , Lachin John M. ,   DCCT/EDIC Research Group
Published: December 2021

Background

Carotid artery intima‐media thickness (IMT) is associated with the risk of subsequent cardiovascular events in the general population. This association has not been established in type 1 diabetes.

Methods and Results

We studied if carotid IMT is associated with the risk of a first coronary artery disease event in participants with type 1 diabetes in the EDIC (Epidemiology of Diabetes Interventions and Complications) study, the long‐term observational follow‐up of the DCCT (Diabetes Control and Complications Trial). Between 1994 and 1996, common carotid artery and internal carotid artery IMT were measured with high‐resolution ultrasound in 1309 study participants with a mean age of 35 years and diabetes duration of 13.8 years; 52% were men. Cox proportional hazards models evaluated the association of standardized common carotid artery IMT and internal carotid artery IMT with subsequent cardiovascular events over the next 17 years. Models were adjusted for age, sex, mean hemoglobin A1c levels, and traditional cardiovascular risk factors. Associations of common carotid artery IMT with subsequent CAD were significant after adjustment for imaging device, sex, and age (hazard ratio [HR], 1.23 per 0.09 mm [95% CI, [1.04–1.45];
P
=0.0141), but did not remain significant after further adjustment for traditional risk factors and hemoglobin A1c (HR, 1.14 per 0.09 mm [95% CI, 0.97–1.33];
P
=0.1206). No significant associations with subsequent coronary artery disease events were seen for internal carotid artery IMT.

Conclusions

In the DCCT/EDIC cohort with type 1 diabetes, common carotid artery IMT, but not internal carotid artery IMT, is weakly associated with subsequent coronary artery events, an association eliminated after adjusting for coexistent traditional cardiovascular risk factors.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifiers: NCT00360815 and NCT00360893.
Pulmonary Hypertension Is Associated With Systemic Arterial Hypertension Among Patients With Normal Left Ventricular Diastolic Function
Authors: Itelman Edward , Segel Michael J. , Kuperstein Rafael , Feinberg Micha , Segev Amit , Segal Gad , Maor Elad , Grossman Ehud
Published: December 2021

Background

The association of pulmonary and systemic arterial hypertension is believed to be mediated through hypertensive left heart disease. The purpose of the current study was to investigate whether pulmonary hypertension (PHT) is associated with systemic arterial hypertension among patients with apparently normal left ventricular diastolic function.

Methods and Results

Consecutive patients who had echocardiographic evaluation between 2007 and 2019 were enrolled. Patients with disease states that are known to be associated with PHT, including diastolic dysfunction, were excluded from the analysis. Estimated right ventricular systolic pressure was extracted for all patients from the echocardiographic reports. PHT was defined as estimated right ventricular systolic pressure >40 mm Hg. Multivariate logistic regression models were applied. Final study population included 25 916 patients with a median age of 59 (interquartile range, 44–69) years, of whom 12 501 (48%) were men and 13 265 (51%) had systemic arterial hypertension. Compared with normotensive patients, hypertensive patients were 3.2 times more likely to have PHT (95% CI, 2.91–3.53;
P
<0.001). A multivariate model adjusted for clinical and echocardiographic parameters that are known to be associated with PHT demonstrated that hypertensive patients are almost 3 times more likely to have PHT (95% CI, 2.45–3.15;
P
<0.001). The association was significant in multiple subgroups but was more significant among women compared with men (odds ratio, 3.1 versus 2.4;
P
for interaction <0.001).

Conclusions

PHT is associated with systemic arterial hypertension irrespective of left heart disease. The association is more pronounced among women.
TÜRKİYE’DE TURİZM TEŞVİKLERİNİN VE JEOPOLİTİK RİSKİN EKONOMİK BÜYÜME ÜZERİNDEKİ ETKİLERİ
Authors: BULUŞ Canberk , BAKIRTAŞ İbrahim , KOÇ Süleyman
Published: December 2021

Bu çalışmanın amacı, Türkiye’de turizm gelirlerinin, jeopolitik riskin, gayrisafi sabit sermaye yatırımlarının ve turizm teşviklerinin ekonomik büyüme üzerindeki etkilerini tespit etmektir. Bu amaç doğrultusunda 1985-2019 dönemi verileri için ARDL sınır testi ile eşbütünleşme analizi gerçekleştirilmiştir. Ampirik bulgulara göre, değişkenler arasında uzun dönemli bir denge ilişkisi tespit edilmiştir. Turizm gelirleri ve sermaye yatırımları ekonomik büyümeyi pozitif etkilerken, jeopolitik riskin negatif etkilediği bulgusuna ulaşılmıştır. Turizm teşviklerinin ekonomik büyüme üzerinde istatistiki anlamlılığa sahip herhangi bir etkisi tespit edilememiştir. Bu bulgulara göre, Türkiye’nin turizm teşviklerinin yasal kapsamı genişletilip sadeleştirilmesinin yararlı olacağı düşünülmektedir. Ayrıca, jeopolitik risklerin azaltılmasına yönelik politikaların ekonomik büyümeyi destekleyeceği ifade edilebilir.
VERASET VE İNTİKAL VERGİSİNE YÖNELİK YENİ YAKLAŞIM VE MODEL ÖNERİSİ
Authors: AYDIN Fazıl
Published: December 2021

Veraset ve intikal vergisi mükellefiyeti süreksiz vergi mükellefiyeti özelliği taşımaktadır. Veraset ve hibe yolu ile karşılıksız (İvazsız) intikaller veraset ve intikal vergisi konusunu oluşturmaktadır. Ölüm sonucunda veraset yolu ile gerçekleşen intikallerde servet değerlemesi büyük bir öneme sahip bulunmaktadır. Covid 19 salgını sonucunda Mart/2020 döneminden itibaren ölüm vakalarının artışı veraset ve intikal vergisinin gerek mükellef sayısını ve gerekse incelemelerinde de artışa neden olmuştur. Bu çerçevede makalede veraset ve intikal vergisine ilişkin önerilere yer verilmiştir.
FAİZSİZ FİNANSAL ÜRÜNLERİ SATIN ALMA DAVRANIŞININ ÖNCÜLLERİ: GEREKÇELİ EYLEM KURAMINA DAYALI UYGULAMALI BİR ÇALIŞMA
Authors: AHMETOĞULLARI Kayhan
Published: December 2021

Dünya genelinde mevcut finansal sistemin sorunları yeni finansal modellere yöneltmektedir. Alternatif modeller içinde hızlı gelişen ve oldukça güvenilir görülen faizsiz finansal sistem ve araçlarıdır. Bu çalışmanın amacı faizsiz finansal ürünlerin satın alınmasında en önemli etkenlerden olan dinsel motif ve faydacı algıların etkisini ölçmektir. Ayrıca Dindarlığın satın alma davranışı üzerinde etkisinde faydacılığın aracı rolüne odaklanılmaktadır. Buna ek olarak katılım banka müşterilerinin dindarlık ve faydacılık anlayışları arasındaki etkileşim incelenmektedir. Araştırma sonuçlarına göre, katılım banka tüketicilerinin satın alma davranışı üzerinde faydacılık algılarının önemli etkisi görülürken, dindarlığın tek başına etkisi saptanmamıştır. Ayrıca, dindarlığın faydacılık algıları üzerinde önemli etkisi gözlenmektedir. En nihayetinde, satın alma davranışları üzerinde dindarlığın etkisini anlamlı kılan ve tam aracılık rolü üstlenen algılanan faydacılık olduğu gözlenmektedir.
OSMANLI BASIN TARİHİNDE BİR İLGİNÇ REKABET: HANIMLAR ÂLEMİ VE KADINLAR ÂLEMİ GAZETELERİ
Authors: KUTKAN Özlem
Published: December 2021

1914 yılında İstanbul’da kısa aralıklarla yayın hayatına başlayan Hanımlar Âlemi (27 Mart 1330 – 24 Temmuz 1330) ve Kadınlar Âlemi (22 Mayıs 1330 -7 Temmuz 1330) gazeteleri isim ve konu /içerik benzerlikleri ile okuyucularına hitap eden iki rakip gazetedir. Nitekim, reklam gelirleri ve satışlarının gazetelerin ayakta kalmaları içinde önemli oluşu ve benzer okuyucu kitlelerine hitap etmeleri kısa sürede iki gazeteyi karşı karşıya getirecek ve ortaya ilginç bir tartışma/ mücadele tablosu ortaya çıkacaktır. Bu makale, gazetelerin kısa tanıtımının ardından dönemin basın kültürü ve edebi akımı üzerinden ilgili süreci somutlaştırmaya çalışmıştır. Böylelikle I. Dünya Savaşı öncesi Osmanlı basın ve kültür dünyasına ilişkin bir boyutun görünür kılınmasına katkıda bulunulması hedeflenmiştir.
AÇIK İNOVASYON VE FİRMA PERFORMANSI İLİŞKİSİ: AÇIK İNOVASYONUN BELİRLEYİCİLERİ OLARAK REKABETÇİ KÜLTÜR VE BİLGİ PAYLAŞIMI
Authors: İMAMOĞLU Salih Zeki , TÜRKCAN Hülya , KILIÇ Ali Hasan
Published: December 2021

Bu çalışmanın amacı, rekabetçi kültür ile bilgi paylaşımının açık inovasyon üzerindeki etkisini incelemek ve açık inovasyonun firma performansı ile ilişkini araştırmaktadır. Araştırma kapsamında, İstanbul ve Kocaeli’nde faaliyet gösteren firmalarda çalışan 274 orta ve üst düzey yöneticiden anket yoluyla veri toplanmıştır. Araştırma sonuçlarına göre, rekabetçi kültür ile açık inovasyonun negatif ilişkili olduğu, bilgi paylaşımı ile açık inovasyonun ise pozitif ilişkili olduğu saptanmıştır. Ayrıca açık inovasyon ile firma performansının pozitif ilişkili olduğu bulunmuştur. Bu bulgular tartışılmış, araştırmacılara ve yöneticilere öneriler sunulmuştur. Böylece araştırma sonuçlarının hem teorik hem de pratik katkılar sunması hedeflenmiştir.
LİNKEDIN SOSYAL İŞ AĞININ KULLANICI ALGISI
Authors: BAKIRTAŞ Hülya , SEKENDÜR Gönül
Published: December 2021

Bu çalışmanın amacı, bireylerin sosyal bir iş ağı olan LinkedIn algısını incelemektir. Araştırma, Mayıs 2018-Ocak 2019 tarihleri arasında gerçekleştirilmiştir. Web tabanlı anket uygulanmıştır. LinkedIn iş ağını kullanan 456 mevcut ve potansiyel işgören üzerinden araştırmanın verileri toplanmıştır. Araştırma bulgularına göre; katılımcıların LinkedIn algılama düzeyleri ile yaşları arasında anlamlı ilişki vardır. LinkedIn fonksiyonellik algısı ile içerik ve etkileşim algısının yanı sıra zaman algısı arasında anlamlı ilişki olduğu görülmektedir. Katılımcıların, LinkedIn fonksiyonellik algısı ile kullanım sıklığı ve profil güncelleme sıklığı arasında istatistiksel olarak anlamlı bir ilişki vardır. Zaman algısı açısından değerlendirildiğinde ise kullanım sıklığı, profil güncelleme sıklığı ve hesabındaki kişi sayısı arasında istatistiksel olarak anlamlı ilişki olduğu bulgusuna ulaşılmıştır. Araştırma hem sosyal ağ hem de insan kaynakları literatürünün genişletilmesi açısından katkı sağlamaktadır.
MEVSİMLİK TARIM İŞÇİLERİNDE GIDA GÜVENCESİZLİĞİ
Authors: EŞTÜRK Özlem , MERT Nilcan
Published: December 2021

Bu çalışmada mevsimlik tarım işçilerinin gıda güvencesizliği durumlarının tespit edilerek, sosyo demografik değişkenlerin gıda güvencesizliği üzerine etkisinin belirlenmesi amaçlanmıştır.Giresun ilinde mevsimlik tarım işinde çalışan 65 hane ile görüşülerek, gıda güvencesi düzeyleri, ABD hanehalkı gıda güvencesi anket modeli (HFSSM) ile belirlenmiştir. Hanelerin gıda güvence düzeyleri belirlenerek, sosyo demografik özellikleri ve gıda tüketim davranışları sıralı lojistik regresyon orantısal odds modeli ile analiz edilmiştir. Çalışmada elde edilen bulgulara göre çocuklu ve çocuksuz hanelerde gıda güvencesine sahip aileye rastlanılamamış, çocuklu hanelerin %28.5’inde ciddi düzeyde açlığın olduğu gıda güvencesizliği seviyesi görülmüştür.Mevsimlik tarım işçisi hanelerinde, çocuklu ve düşük gelirli hanelerin gıda güvencesizliği riskinin arttığı ve bu durumun kaygı verici boyutta olduğu görülmüştür. Mevsimlik tarım işinde çalışan hanelere yönelik sosyal ve ekonomik yönden desteğe ve özel programlara ihtiyaç duyulmaktadır.
FİNANSAL PAZARLAMA KAPSAMINDA KRİPTO PARA PAZARLAMASI VE KRİPTO PARA BİRİMLERİNİN BİLİNİRLİĞİ VE FARKINDALIĞI
Authors: İRİ Ruhan
Published: December 2021

Araştırma, finansal bir ürün olan kripto para birimlerinin tanıtım ve pazarlamasında tüketici (yatırımcı) algılama ve düşünce düzeylerini ölçmek amacıyla hazırlanmıştır. Araştırma örneklemini, Türkiye genelinde kripto para birimleriyle ilgilenen veya yatırım yapan toplam 355 tüketici oluşturmaktadır. Araştırma sonucunda, katılımcıların kripto para birimleriyle ilgili algılama ve düşünceleri ile ilgili 8 ifadeye faktör analizi uygulanmış, analiz sonucunda özdeğerleri birden büyük tek faktör bulunmuştur ve faktöre “Kripto Para Birimi Pazarlama ve Tanıtım Boyutu” ismi verilmiştir. Faktöre ait güvenirlik katsayıları (Cronbach Alpha) değeri ,811 olup, faktörleri oluşturan boyutun güvenilir olduğu söylenebilir. KMO analizi sonucu 0,860 ve Barlett’s Test of Sphericity analizi sonucu 875,901 olduğu belirlenmiş ve her iki test sonucu da P=0,000 önem düzeyinde anlamlı bulunmuştur.
VERGİ CEZA HUKUKUNDA VERGİ SUÇLARI KAPSAMINDA CEZAYI ETKİLEYEN HUSUSLAR
Authors: ERCAN Taner
Published: December 2021

Hukuk devleti prensipleri gereği kanunsuz vergi olmadığı, her türlü verginin yasalarda yer aldığı şekil ve usullerde toplanacağı kabul edilmektedir. Söz konusu durumda vergileme alanında hayatın olağan akışına yönelik olarak birtakım uyuşmazlıklar ortaya çıkabilmektedir. Vergisel alanda kabahat ve vergi suçu bağlamında zuhur eden olası uyuşmazlıklar, idari yargı ve vergi ceza yargısı çerçevesinde çözümlenmektedir. Vergi suçlarında korunan hukuki yarar kamu düzeni ve hazine yararı olmasından dolayı vergi suçu vergi ceza hukuku kapsamında değerlendirilmektedir. Söz konusu süreçte vergi suçuna yönelik durum muhtelif şekillerde devam ettiği gibi farklı biçimlerde de sona ermekte ve ceza sürecinden etkilenebilmektedir. Bu minvalde çalışmadaki amaç ceza hukuku bağlamında vergi ceza hukukunun yeri ve önemini tespit etmek ayrıca vergi ceza hukuku kapsamında ortaya çıkan vergi suçlarını yasalar çerçevesinde kanunlarda belirtilen yönde etkileyen, sona erdiren unsurları ortaya koymaktır.
TRABZON’UN YÖRESEL BİR LEZZETİ: SİMİRA
Authors: KURT Elif , BADEM Abdullah
Published: December 2021

Trabzon, coğrafi ve iklim özellikleri, tarihi geçmişi ve zengin mutfak kültürü ile önemli kültürel değerlere sahip bir kenttir. Zengin mutfak kültürünün oluşmasında bitki örtüsündeki çeşitlilik ve yöreye özgü lezzetlerin rolü büyüktür. Nitel bir araştırma olan bu çalışmada, yöresel yemeklerin korunması ve devamlılığının sağlanması için Trabzon’a özgü bir yemek olan simiranın tanıtılması ve alana kazandırılması amaçlanmıştır. Çalışmada, laz kökenli, 41-73 yaş aralığındaki, 11 kadın ile yüz yüze görüşme sağlanmış, yarı yapılandırılmış soru formu kullanılmış ve elde edilen bulgular kayıt altına alınmıştır. Simiranın yapımında kullanılan yenilebilir otlardan bazıları darı mancarı, ısırgan, pazı, küllü ot (sirken), petek otu ve zolayda olduğu belirlenmiştir. Bu otlar ve diğer yenilebilir otların sağlığa katkıları hakkında bilgi verilmiş olup, bu durum da göz önünde bulundurulduğunda simiranın gastronomik unsur olarak kullanılmasının hem turizme hem de insan sağlığına katkı sağlayacağı belirtilebilir.
OTEL ÇALIŞANLARININ SOSYO-DEMOGRAFİK ÖZELLİKLERİNE GÖRE İŞE GÖMÜLMÜŞLÜK DÜZEYLERİ
Authors: DOĞANTEKİN Ali , SEÇİLMİŞ Cihan
Published: December 2021

Bu araştırmanın amacı; dört ve beş yıldızlı otel çalışanlarının işe gömülmüşlük düzeylerinin demografik özelliklerine göre farklılaşıp farklılaşmadığını ortaya koymaktır. Araştırma verileri, İstanbul’daki dört ve beş yıldızlı otel çalışanlarından toplanmıştır. Uygulama aşamasında kullanılabilir 492 anket toplanmış ve analizlerde SPSS ve AMOS paket programları kullanılmıştır. Dört ve beş yıldızlı otel çalışanlarının işe gömülmüşlük düzeylerinin demografik özelliklerine göre farklılaşıp farklılaşmadığını ortaya koymak için t-testi ve tek yönlü ANOVA analizleri tercih edilmiştir. Bulgular; otel çalışanlarının, işe gömülmüşlük düzeylerinin cinsiyet ve yaşa göre farklılık göstermediğini ortaya koymaktadır. Ancak evli ve beş yıldızlı otel çalışanlarının işe gömülmüşlük düzeyleri daha yüksektir. Otel çalışanlarının eğitim düzeyleri, aylık gelirleri ve aynı işletmedeki deneyim süreleri arttıkça işe gömülmüşlük düzeyleri artmaktadır. Son olarak otel işletmelerinde arka planda görev alan bölümler olan muhasebe, satış-pazarlama, mutfak bölümleri çalışanlarının işe gömülmüşlük düzeyleri daha yüksektir.
TAŞ SACI KULLANIMININ BARTIN İLİ MUTFAK KÜLTÜRÜNDEKİ BİLİNİRLİLİĞİNİN İNCELENMESİ
Authors: CÖMERT Menekşe , KIRMIZIKUŞAK Duygu
Published: December 2021

Mutfak kültürüne yönelik geleneksel bilgiler kuşaklar boyunca aktarılarak bugüne kadar gelmiştir. Ancak zamana yenilen ve önemi azalan mutfak gelenekleri de mevcuttur. Taş sacı Bartın, Zonguldak ve Kastamonu illeri tarafından benimsenen 200 yıllık geçmişe sahip geleneksel bir mutfak ekipmanıdır. Bu ekipman geçmişten bugüne kadar Bartın ekmeği, börek ve kuru yufka yapımında kullanılmaktadır. Bu çalışmada amaç, Bartın ili mutfak kültürüne ait bir ekipman olarak kabul edilen taş sacının sürdürülebilirliğini sağlamaktır. Araştırmada veriler 28.05.2021 tarihinde Bartın'da galla pazarı olarak bilinen kadınlar pazarında gönüllü olarak katılan 11 kişi ile görüşülerek toplanmıştır. Veriler, MAXQDA programı ile analiz edilmiştir. Araştırmanın sonuçları, Bartın'da şehirleşmenin etkisi ile taş sacına olan talebin azaldığını göstermektedir. Ayrıca bu geleneğe verilen önemin de azaldığı görülmektedir. Çalışmanın mutfak kültüründe yok olmaya yüz tutmuş geleneklerin unutulmaması ve bu geleneklerin sürdürülebilirliği açısından da katkı sağlayacağı planlanmaktadır.
ARK ROYAL ‘‘İNGİLİZ DENİZ HAKİMİYETİNİ SİMGELEYEN İSİM’’
Authors: ARSLAN Mehmet
Published: December 2021

16.yüzyılda açık denizler için Avrupa ülkeleri arasında üstünlük kurma mücadelesi vardır. Bu üstünlük kurma mücadelesinde İspanya öndedir. 1588 yılında bu mücadele çerçevesinde İngiltere Ark Royal Savaş gemisi öncülüğünde İspanya’yı mağlup etmiş ve açık denizlerde üstünlüğü ele geçirmiştir. 1636 yılına gelindiğinde Ark Royal İngiltere’nin Medway Nehri’nde batmıştır. Bu batıştan 278 yıl sonra 1914 yılında dünya tarihinin bilinen ilk uçak gemisine Ark Royal ismini vererek, Ark Royal’in tarih sahnesine geri dönmesini sağlamıştır. Ark Royal’in geri dönüşüyle beraber ilk görevlendirilme yeri, şubat ayı itibariyle, Çanakkale olmuştur. Mayıs ayından itibaren ise Ark Royal Çanakkale bölgesinden çekilmeye başlamıştır. Görev alanı sadece Çanakkale ile sınırlı kalmayan Ark Royal uçak gemisi, 1923 yılına kadar İngiltere’ye hizmet etmiştir Bu tarihten sonra uçak gemilerinin en üst modellerine İngiltere bu ismi vererek, Ark Royal ismini yaşatmaya çalışmıştır.
THE IMPACT OF AZERBAIJAN-TURKMENISTAN ENERGY COOPERATION ON THE CASPIAN ENERGY SECURITY
Authors: KASIM Kamer
Published: December 2021

With the end of the Cold War, a global competition began for the exploration, extraction and transportation of the Caspian energy resources. It is suggested that the cooperation of the two energ-rich countries, Azerbaijan and Turkmenistan, will not only increase the influence of these countries in the international arena, but also contribute to the energy security. Turkmenistan’s active foreign policy with Berdimuhamedov increased the impact of Turkmenistan on the energy projects. Azerbaijan, on the other hand, will be able to focus more on energy projects after it liberated its territories from the Armenian occupation in the Nagorno-Karabakh conflict with a successful military operation. In this article, the cooperation of Azerbaijan and Turkmenistan is analyzed within the framework of the developments in foreign policies of these countries and regional security.
Genome wide identification of mungbean (Vigna radiata [L.] R. Wilczek) Late Embryogenesis Abundant (LEA) protein gene family
Authors: Likhith Rampura K. , Alagarasan Ganesh , Muthurajan Raveendran , Parasuraman Boominathan , Subramanian Rajesh
Published: December 2021

Mungbean (Vigna radiata L. Wilczek) an important legume crop with valuable nutritional and health benefits is severely affected by drought conditions. Desiccation tolerance is a capacity of seeds to survive and maintain physiological activities during storage and stress conditions. LEA proteins are group of stress associated proteins that help the plants survive water deficit stress. Here we have performed genome-wide analysis of mungbean LEA (VrLEA) genes, and also insilico physical/functional characterization. Gene-positioning showed that 307 VrLEAs are present in all the eleven chromosomes, but are unevenly distributed. Upstream promoter sequence analysis of LEA genes revealed the occurrence of MYB transcription factor (TF)in higher number compared to other TFs i.e., bZIP, AP2, WRKY, NAC and bHLH.Further, we downstreamed our analysis to fewer VrLEAs, based on drought responsive data. The VrLEAs obtained from the earlier experimental data were examined for its organelle localization and found that they are intracellular functional proteins.
The Spatial History of Revelation in Carl Ritter’s Erdkunde (1817–59)
Authors: Benes Tuska
Published: December 2021

Traditional theological concepts, including revelation, shaped academic disciplines as they emerged in nineteenth-century Germany. The first university professor of geography, Carl Ritter, crafted an intriguing spatial history of revelation in his masterful Earth Science in Relation to Nature and the History of Man (1817–1859). The teleological bent of Ritter’s geography and his commitment to intelligent design have encouraged most commentators to regard Ritter as a late manifestation of physicotheology. However, this long-standing explanation of a crucial geographer’s religious platform misconstrues the field’s theological commitments. Physicotheology suffered irreversible losses in the German states in the late eighteenth century. Ritter’s adherence to primordial revelation and biblical literalism typify the religious awakening of the Napoleonic period more than enlightened rationalism. He is best understood as a geographer of religion, dedicated to evangelical missions and intrigued by how the Earth’s features shaped the spread and transformation of religious ideas and practices, including Buddhism.
‘Babe… you're a bit of a know it all’:
Authors: Dennie Danielle , Breier Susie
Published: December 2021

This study employed a novel user experience method, the love/breakup letter, to evaluate the usefulness of an online information literacy (IL) tutorial for students writing assignments with research requirements. Thematic coding of the letters showed that this method elicited revealing responses from students about their confidence in doing library research, preferred learning styles, and intentions to use such a tool again. In contrast with highly-favourable prelaunch user testing results, the majority of students wrote breakup letters to the tutorial and several bypassed it altogether despite their explicit assignment instructions. The findings have implications for librarians exploring new research methods and investigating practical applications of online IL teaching tools designed for self-directed learning.
Capturing the big picture
Authors: Gill Navroop , Springall Elena
Published: December 2021

This project report describes an internal scan of library staff involved in instruction in a large academic library system. 64 semi-structured interviews were conducted and qualitatively analysed in order to produce a summary of instruction across the library system, and both the challenges faced and supports desired by these instructors. The most often mentioned challenges included the wide variety of students and class characteristics encountered, limitations around time, and navigating faculty expectations. The supports described with greatest frequency were professional development opportunities to support instruction practice, a greater sense of community among those doing instruction, and increased awareness of instruction practices both across the library system and in the institution at large. These finding allowed the authors to form recommendations for the library system to help advance instruction in support of teaching and research in the institution.
An Algorithm for Detecting the Chesapeake Bay Breeze from Mesoscale NWP Model Output
Authors: Hawbecker Patrick , Knievel Jason C.
Published: December 2021

A novel algorithm is developed for detecting and classifying the Chesapeake Bay breeze and similar water-body breezes in output from mesoscale numerical weather prediction (NWP) models. To assess the generality of the new model-based detection algorithm (MBDA), it is tested on simulations from the Weather Research and Forecasting (WRF) Model and on analyses and forecasts from the High-Resolution Rapid Refresh (HRRR) model. The MBDA outperforms three observation-based detection algorithms (OBDAs) when applied to the same model output. In addition, by defining the onshore wind directions on the basis of model land-use data and not on the actual geography of the region of interest, performance of the OBDAs with model output can be improved. Although simulations by the WRF Model were used to develop the new MBDA, it performed best when applied to HRRR analyses. The generality of the MBDA is promising, and additional tuning of its parameters might improve it further.
Impact of Adenotonsillectomy on Homework Performance in Children With Obstructive Sleep-Disordered Breathing
Authors: Wu Derek , Au Vivienne H. , Yang Billy , Horne Sylvia J. , Weedon Jeremy , Bernstein Michelle J. , Goldstein Nira A.
Published: December 2021

Objective:

As a first line treatment for pediatric obstructive sleep-disordered breathing (SDB), adenotonsillectomy (AT) has been shown to confer physiologic and neurocognitive benefits to a child. However, there is a scarcity of data on how homework performance is affected postoperatively. Our objective was to evaluate the impact of AT on homework performance in children with SDB.

Methods:

Children in grades 1 to 8 undergoing AT for SDB based on clinical criteria with or without preoperative polysomnography along with a control group of children undergoing surgery unrelated to the treatment of SDB were recruited. The primary outcome of interest was the differential change in homework performance between the study group and control at follow-up as measured by the validated Homework Performance Questionnaire (HPQ-P). Adjustments were made for demographics and Pediatric Sleep Questionnaire (PSQ) scores.

Results:

116 AT and 47 control subjects were recruited, and follow-up data was obtained in 99 AT and 35 control subjects. There were no significant differences between the general (total) HPQ-P scores and subscale scores between the AT and control subjects at entry and there were no significant differences in the change scores (follow-up minus initial scores) between the groups. Regression modeling also demonstrated that there were no group (AT vs control) by time interactions that predicted differential improvements in the HPQ-P ( P > .10 for each model) although initial PSQ score was a significant predictor of lower HPQ-P scores for all models.

Conclusions:

Children with SDB experienced improvement in HPQ-P scores postoperatively, but the degree of change was not significant when compared to controls. Further studies incorporating additional educational metrics are encouraged to assess the true scholastic impact of AT in children with SDB.
Categorisation in Forest Areas: A Study of the ‘OTFDs’ in the Forest Rights Act
Authors: Choubey Kamal Nayan
Published: December 2021

There are certain demarcated tribal areas in our country where the Scheduled Tribes (STs) have special community rights to live their lives according to their customs and maintain control over local natural resource management. The Sixth Schedule and Fifth Schedule are examples of such areas, and after the enactment of the Forest Rights Act, (FRA), 2006, there are crucial preferential provisions for the STs in forest areas of the whole country too. This article probes the historical development of categorisations in India, particularly in the context of forest-dwelling communities, and attempts to examine constitutional provisions and the provisions of different laws passed by the Parliament to evaluate the situation of other minority communities, particularly dalits, living in ‘forest areas’. In this context, the article primarily focuses on the genesis and practice of the Other Traditional Forest Dwellers (OTFDs) category. Based on the field study of the Taungya village, the article shows the problem of categorisation in forest areas and marginalisation of dalits due to this process and emphasises the need for a more dialogical and democratic process of categorisation in India.
The CM Window in Haryana: A Landmark Initiative for Grievance Redressal
Authors: Dayal Bhupeshwar , Dhaka Rajvir
Published: December 2021

Grievance redressal is often a general administrative exercise which is adopted by various state governments and agencies with varying degrees of commitment and efficacy. An ideal redressal mechanism aims at safeguarding degrees against official apathy, corruption and systemic aberrations. It also implicitly acts as a deterrent to erring agencies and functionaries as well as sets a benchmark for a higher executive’s oversight to peoples’ complaints. A revisit to the course and manner of this hitherto routine exercise reveals that the functional and effectual system for addressing people’s grievances has to include a mechanism which is specific as well as achievable and includes a procedure for measurable performance. The CM Window initiative of the Government of Haryana has set its sight at unrestricted grievance redressal across departments and geographical spreads of the state through a process of decentralised complaint recording, prompt solutions and centralised monitoring at the highest level. This article offers a closer insight into the focus, working, effectiveness and limitations of the ambitious exercise to ameliorate citizens’ hardships.