bluuebunny/crossref_metadata_2025 huggingface dataset:
(182) THE EFFECT OF THE NEW 75 MG ORODISPERSIBLE FILM OF SILDENAFIL ON ERECTION AND SEXUAL QUALITY OF LIFE: INSIGHTS FROM AN OBSERVATIONAL STUDY.
Authors: Dr. Andrea Sansone , Dr. Valeria Frangione , Dr. Arturo Lanzarotti , Dr. Andrea Cocci , Dr. Carlo Ceruti , Prof. Marco De Sio , Prof. Ciro Imbimbo , Prof. Vincenzo Mirone , Prof. Luigi Schips , Prof. Carlo Terrone , Prof. Emmanuele A Jannini
Published: July 2023

Objectives

We investigated the effects of the sildenafil orodispersible film (ODF) 75 mg dose on both sexual quality of life and erectile function based on the results from an observational study in daily practice in Italy.

Methods

This was a post-hoc analysis of results from an observational, real-life study carried out in six centers in Italy on ED patients. All subjects were asked to take the prescribed dosage of Sildenafil ODF at inclusion (Visit 1) and to return for a control visit (Visit 2) to confirm or adapt the prescribed dose after a minimum of 4 weeks. An End of study Control visit (Visit 3) was performed after additional 4 weeks. Erectile function was assessed by the International Index of Erectile Function – Erectile Function Domain (IIEF-EF); sexual quality of life was measured using the sexual QoL instrument for men (SQoL-M).

Results

Among the 36 subjects initially recruited for the 75 mg dose, five patients dropped out of the study (2 at visit 2 and 3 at visit 3), none of which due to treatment inefficacy or serious adverse events. At visit 2, the mean IIEF-EF scores significantly increased (∆ = 7.97±4.71, p <0.0001) as SQoL-M scores also did (∆ = 10.76±10.46, p <0.0001). At visit 3, IIEF-EF and SQoL-M scores were still significantly improved compared to baseline (∆ = 10.64±7.01, p <0.0001 and ∆ = 18.15±12.32, p <0.0001, respectively). By ANCOVA, we found no significant effect for age, BMI, previous use of PDE5i, presence of metabolic comorbidities, and smoking habits on study outcomes at both visits 2 and 3.

Conclusions

The use of the ODF formulation for sildenafil represents an effective and safe novel opportunity to take care of ED patients, significantly improving both erectile function and sexual quality of life in patients undergoing treatment.

Conflicts of Interest

AS has been a consultant for Menarini. EAJ is/has been a consultant and/or paid speaker for Bayer, IBSA, Menarini, Merck-Serono, Otsuka, Pfizer Inc, Shionogi, and Viatris. VF and AL are full-time employees of IBSA. AC has no conflicts of interest. CC has been a consultant and/or paid speaker for Dompè Primary, Menarini, Takeda, Alphremev, SOFAR. MDS is/has been paid speaker for Janssen, Astellas, Leonardo Medica. CI has no conflicts of interest. VM has been a consultant and/or paid speaker for SR, Recordati, Janssen. LS has no conflicts of interest. CT has no conflicts of interest.
(312) PLATELET-RICH PLASMA (PRP) TREATMENT AND PENILE REJUVENATION IN PATIENTS WITH ERECTILE DYSFUNCTION: THE ROLE OF MEAN PLATELET VOLUME
Authors: Dr. Davide Francomano , Prof. Federico Dehò , Prof. Paolo Capogrosso , Prof. Sandro La Vignera , Prof. Gabriele Antonini , Prof. Antonio Aversa
Published: July 2023

Objectives

Erectile dysfunction (ED) is one a common disorder in adult males and current therapies are symptomatic and do not influence disease progression. By contrast, regenerative medicine may potentially reverse or stop the progression of ED and restore erectile capacity. We aimed to evaluate the clinical correlates of platelet function before platelet-rich plasma (PRP) injection and its potential efficacy in men with vascular ED poorly respondent to PDE5i.

Methods

To this purpose, 150 patients (Age: 51±16.7; mean IIEF5: 12±2.6; mean PSV: 32±5.5; Mean MPV=9.3±1.1) were submitted to a single-shot treatment of PRP. All patients were evaluated at baseline for mean platelet volume (MPV), and at baseline and 1 month after treatment for IIEF5 and dynamic penile duplex ultrasound (d-PDU) according to Aversa et al (Andrology, 2021; 9:1457-1466).

Results

All patients had a significant improvement in ED symptoms (IIEF5: 12±2.6 vs 19±3.0; p<0.0001) and a significant improvement at d-PDU (PSV: 32±5.5 vs 42±7.6; p<0.0001). The ROC analysis showed a significant accuracy (72.1%, C.I.64.0 - 80.2, p <0.0001) for MPV in identifying men clinically responding to PRP with favourable outcomes (+4 points in IIEF5 score). In particular, an MPV<8.95 was recognized as the best threshold with a sensitivity of 90% and specificity of 54.1%.

Conclusions

This study provides the first evidence that PRP outcomes correlate with baseline MPV in patients with ED and poorly responding to PDE5i. MPV below 8.95 identify patients with lower response to treatment that might benefit of re-treatment.

Conflicts of Interest

None
(200) PEYRONIE'S DISEASE SURGERY GRAFTING AREA REDUCTION: A COMPARATIVE ASSESSMENT BETWEEN IGRAFTER APP VS DOUBLE Y USING VALIDATED LOW-COST 3D-PRINTED PENILE MODELS
Authors: Prof. Bruno Machado , Alexandre Miranda , Eduardo Miranda , Prof. Bruno Nascimento
Published: July 2023

Objectives

Compare 2 PIG techniques, the iGrafter and Double-Y in 3 main aspects: I) Total grafting area; II) The variation in calculating the grafting to be used; III) time to perform the PIG.

Methods

Six urologists with expertise in sexual medicine performed both techniques twice using four 3-D vali-dated training models for PD with a standard 60° uniplanar dorsal curvature.

Results

For all surgeons, the use of iGrafter resulted in 2 grafts, for the Double Y technique in 1 graft. The Total Time of surgery was significantly longer for the iGrafter than for DY technique: 49 min +/- 11 min vs 40.7 min +/-5.7 min, respectively (P = 0.02). The iGrafter grafting area was significantly smaller to the Double Y technique (11.6 cm2 +/- 1.2 cm2 vs 23.3 cm2 +/- 5.4 cm2, respectively (P = 0.01), representing a 50.2% grafting area reduction for the iGrafter when compared to the DY. The variation of graft area, using the iGrafter also yielded a more consistent graft across all surgeons when compared to the DY technique (CV = 10.56% for the iGrafter vs 23.28% for the DY).

Conclusions

Using the iGrafter software for PIG surgery has shown to be a promising technique for severe Peyronie's Disease management resulting in smaller graft size (about 50% smaller when compared to the DY) which can potentially mean less erectile dysfunction for the patients operated by this technique.

Conflicts of Interest

The Authors have no conflict of interest.
(235) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM FOR THE TREATMENT OF PEYRONIE'S DISEASE – A SINGLE CENTRE EXPERIENCE
Authors: Dr. Dejan Bratus , Uros Bele , Tina Bratus
Published: July 2023

Objectives

Several conservative treatments have been tried for the treatment of Peyronie's disease in the last decades. All of them have failed to show significant efficacy in placebo controlled trials. Intralesional application of collagenase Clostridium histolyticum (Xiapex®) is one of the newer treatment possibilities and was introduced with a hope that it would reduce the number of men requiring surgery for this condition. Xiapex® consists of a mixture of purified class I and class II collagenases which cause enzymatic disruption of the fibrotic plaque by synergistically hydrolyzing the triple helical conformation of types I and III collagen. It also down regulates many of the growth factors, genes and cytokines that are involved in the pathogenesis of Peyronie's disease.

Methods

22 patients with diagnosed Peyronie’s disease were treated and the applications of collagenase Clostridium histolyticum were performed by two urologists. The inclusion criteria were diagnosed Peyronie’s disease with a fibrotic plaque causing the penile curvature between 30° and 60°. All patients were treated with two cycles of collagenase Clostridium histolyticum injections. The injections were applied a week apart in a single cycle and the cycles were 6 to 8 weeks apart. Patients were instructed to perform penile modelling (stretching and straightening) at home in between the cycles.

Results

The efficacy and side effects were evaluated at each visit and also 3 months after the last application. The satisfaction rate of treated men was extremely high and only two men reported no significant improvement and were scheduled for a surgical repair of penile curvature. There were no serious side effects reported, only some minor local changes in form of swelling and bruising of the penis.

Conclusions

Application of collagenase Clostridium histolyticum proved to be an effective and safe procedure for the treatment of Peyronie’s disease.

Conflicts of Interest

All authors declare no conflict of interest.
(131) CAN DELAYED EJACULATION HAVE AN IMPACT ON PSYCHOLOGICAL HEALTH? FINDINGS FROM A CROSS SECTIONAL STUDY
Authors: Christian Corsini , Federico Belladelli , Edoardo Pozzi , Fallara Giuseppe , Simone Cilio , Massimiliano Raffo , Fausto Negri , Ludovica Cella , Margherita Fantin , Alessandro Bertini , Francesco Lanzaro , Luigi Candela , Luca Boeri , Paolo Capogrosso , Alessia D'Arma , Francesco Montorsi , Andrea Salonia
Published: July 2023

Objectives

Delayed Ejaculation (DE) is among the most challenging male sexual dysfunctions. We aimed to explore and compare the sociodemographic and clinical characteristics of men with DE with those complaining of primary premature ejaculation (PE).

Methods

Data from 555 consecutive men seeking first medical help for DE and/or primary PE between 2005 and 2022 at a single tertiary-referral center were retrospectively analyzed. Complete socio-demographic, clinical and laboratory data were collected. All patients completed the International Index of Erectile Function (IIEF) and the Beck Depression Inventory (BDI) at baseline. We excluded men with known or potential causes responsible for ejaculatory disorders (n= 52). Descriptive statistics was used to detail and compare clinical and sociodemographic characteristics between the two groups (DE vs. PE). Linear regression models tested the association between depressive symptoms (BDI) and baseline IIEF domains scores among men with DE.

Results

Of 555 patients, 479 (86.3%) and 76 (13.7%) primary PE and DE, respectively. Men with DE were significantly older (44 vs. 47, p=0.01) than patients with PE. Conversely, the two groups did not differ in terms of educational/relational status, BMI, comorbidities, and hormonal milieu. At psychosexual interview, men with DE report more frequently symptoms referable to anxiety and depression (9.4% and 12,7%) along with higher median baseline BDI scores (8 vs. 6), all p<0.01. DE patients reported lower median IIEF-OF, -SD domains (6 vs. 9) and (7 vs. 8) than patients with PE only, all p<0.05. At linear regression analysis, among DE patients, a higher BDI score was associated with lower IIEF -OS (coeff.-1.57, CI[-2.60,-0.53], p<0.004), and IS (coeff.-0.72, CI[-1.29,-0.16], p=0.01) domains (Figure 1). No association between BDI and IIEF-OF, -EF, -SD domains was found

Conclusions

Among men with complaining of ejaculatory disorders, one out of ten reports DE. These patients have higher chances to report clinically significant depression significantly impacting on their overall satisfactory sexual life.

Conflicts of Interest

None
(221) ON-DEMAND PAROXETINE FOR PREMATURE EJACULATION - SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Dr. Faisal Nawaz , Dr. Simon Williams
Published: July 2023

Objectives

This review aims to compare the efficacy of On-demand Paroxetine to on-demand Dapoxetine and Placebo for the treatment of Premature Ejaculation.

Review question

In patients with premature ejaculation, does on-demand Paroxetine increase the Intravaginal ejaculatory latency time compared to on-demand Dapoxetine therapy?

Methods

Electronic databases were systematically searched to identify the eligible Randomized Controlled Trials, comparing on-demand Paroxetine to Dapoxetine or placebo, following the Cochrane Collaboration methodology. Non-randomized trials were excluded.

The Protocol for this systematic review was prospectively registered on PROSPERO - International Prospective Register of Systematic Reviews with the reference number CRD42022316352.

Results

Highly sensitive search strategies were designed following the PRISMA-S guidelines to search the MEDLINE, Cochrane CENTRAL, EMBASE, PsycINFO, and other bibliographic databases. Subject terms (MeSH) "Premature Ejaculation", "Paroxetine", "Dapoxetine", and "on-demand" were adapted to each database for a comprehensive literature search. Results are reported in line with PRISMA guidelines. 1171 abstracts were identified for screening by two independent reviewers using the Covidence software. Full-text screening of the 30 records was performed. The meta-analysis included nine eligible randomized controlled trials, recruiting a total of 721 participants. Meta-analysis was performed using the Cochrane Collaboration's Review manager software.

Conclusions

Meta-analysis of the included studies favored on-demand Paroxetine over Dapoxetine; however, the IELT improvement was not statistically significant with the on-demand Paroxetine. There was a high degree of heterogeneity among the included trials. On-demand Paroxetine does not significantly prolong the IELT compared to the on-demand Dapoxetine and Placebo. Significant heterogeneity and inconsistencies were found among the included studies. The certainty of the evidence of study outcomes was affected mainly by the study limitations, imprecision, and small sample size. A well-designed, large RCT is required to provide further evidence to support this hypothesis.

Conflicts of Interest

Nothing to declare.
(281) TESTOSTERONE DEFICIENCY AND RISK OF COGNITIVE DISORDERS IN AGING MALES:RESULTS FROM A META-ANALYSIS STUDY
Authors: Dr. Walter Vena , Dr. Nicola Bianchi , Dr. Francesca Frizza , Prof. Giulia Rastrelli , Dr. Alessandra Sforza , Dr. Alessandro Brunetti , Dr. Alessandro Pizzocaro , Prof. Mario Maggi , Dr. Giovanni Corona
Published: July 2023

Objectives

The aim of the present study is to systematically meta-analyze and discuss all the available evidence regarding the possible role of Testosterone replacement therapy (TRT) in age-depended male cognition impairment and dementia.

Methods

A comprehensive Medline, Embase and Cochrane search was performed including the following words: [“testosterone”[MeSH Terms] OR “testosterone”[All Fields]] AND [“cognition”[MeSH Terms] OR “cognition”[All Fields]]. All placebo-controlled trials evaluating the effect of TRT on several cognition outcomes without any restriction were included. Since the classification of tests into cognitive domains differed among the included studies, the available neuropsychological tests were divided into seven cognitive domains, based on an established neuropsychological reference text as previously reported. In order to obtain more comparable results, only trials with homogenous cognitive tests were analyzed.

Results

Overall, 17 studies were available including 1438 patients with a mean age of 70.4 years and a mean follow-up of 45.6 weeks. These trials differ in basal TT levels and type of T preparation used. In addition, nine were performed in aging men without memory problems, five in subjects with mild to moderate cognitive impairment and two in patients with Alzheimer’s disease. When TRT was compared to placebo, no difference in all the cognitive domains analyzed was observed. In addition, no differences were also observed when depressive symptoms or score derived from Mini-Mental State Examination test were considered or when only patients with cognitive impairment were considered.

Conclusions

Present data did not support the use of TRT for the improvement of several cognitive domains analyzed including attention/working memory, executive function, language, verbal memory, visual memory, visuomotor ability, and visuospatial ability. However, it is important to recognize that the vast majority of available RCTs included mixed populations of subjects with eugonadism and hypogonadism preventing any final conclusions

Conflicts of Interest

No conflict of interest to declare.
(218) ONCO-MICROTESE IN PATIENTS SUFFERING FROM CONCOMITANT TESTICULAR CANCER AND AZOOSPERMIA: A SINGLE-CENTER EXPERIENCE
Authors: Dr. Alessandro Giordano , Dr. Angelo di Giovanni , Dr. Carlo D'alterio , Dr. Claudio Marino , Dr. Lorenzo Cirigliano , Dr. Luigi Napolitano , Dr. Federica Cariati , Dr. Roberto La Rocca , Prof. Alessandro Palmieri , Dr. Marco Capece
Published: July 2023

Objectives

Testicular cancer (TC) accounts for 1% of all tumors and 6-24% of these patients are azoospermic at diagnosis. Moreover in most of these patients, adjuvant chemotherapy results in a decreased spermatogenesis function. The aim of the present study is to report the outcomes of onco-microTESE in our center case series.

Methods

From January 2019 to September 2022 we enrolled eleven patients aged from twenty-four to thirty-nine affected by testicular cancer and azoospermia. The diagnosis of TC was made by physical examination, scrotal ultrasound and tumor markers (αFP, βHCG, LDH). Two semen analysis and evaluation of testosterone, FSH, LH, estradiol, prolactin were performed before treatment. After surgery, tumor volume (TuV) and testicular volume (TeV) were measured and the ratio between them was evaluated (TuV/TeV).

All patients underwent onco-microTESE with the help of an operator microscope and with the aid of a biologist in the surgery room.

Statistical analyses were performed to correlate FSH, TuV and TeV.

Results

Six out of eleven patients had high FSH level while the LH was normal in all patients. In five out of eleven patients testicular volume was <12ml. Spermatozoa were successfully retrieved and frozen from 4/11 testes (36.36%). In all these cases TuV/TeV were <0,1 and in three out of four patients FSH was normal

Conclusions

In conclusion onco-microTESE should be considered the gold standard for patients with concomitant azoospermia and TC. Despite the low number of patients enrolled due to the rarity of such a condition, we observed a positive correlation between normal FSH and TuV/TeV<0,1 with surgical sperm retrieval (SSR). Further studies are required to evaluate the effective use of these parameters in preoperative evaluation of azoospermic patients with testicular tumors.

Conflicts of Interest

The Authors declair no conflict of interest.
(232) HIGH INTENSITY LASER THERAPY IMPROVES ERECTILE FUNCTION IN SHORT TERM: A PILOT STUDY
Authors: Dr. Chirag Bhandari
Published: July 2023

Objectives

This study aimed to assess the effectiveness of high-intensity laser therapy (HiLT) in patients suffering from mild-to-severe ED.

Methods

This prospective study included 25 patients 20–57 years of age with a confirmed diagnosis of ED with the five-item version of the International Index of Erectile Function (IIEF-5). After a washout period of oral medicines, patients were treated with HiLT and pelvic floor muscle exercises. All patients received 15 sessions of treatment with a high-powered diode laser (Chattanooga HPL-7W, USA) at a frequency of twice per week. In a supine position, laser irradiation was administered to the penis's shaft and crura. The shaft of the penis was irradiated with 1000 joules at 3 watts in continuous mode for xxx minutes, while the crura and perineum were treated with 1500 joules at 5 watts in continuous mode for xxx minutes. The assessment was done before and one month after the treatment by IIEF-5 and erection hardness score (EHS).

Results

Significant differences were found between the baseline (14.76 ± 4.82) and 1-month follow-up (23.48± 1.69, p<0.0001) mean IIEF-5 questionnaire scores. Similarly, the mean EHS following therapy was significantly higher than at baseline (2.84±0.69 vs 3.96±0.04, p<0.0001). The percentage of patients with EHS>2 at baseline increased from 32% (8/25) to 100% (25/25) at the one-month follow-up. All reported side effects were mild and vanished in one week.

Conclusions

HILT seems to be effective in improving erectile function in patients suffering from mild-to-severe ED. Further studies are required to elaborate the role of HILT in the treatment of ED.

Conflicts of Interest

None
(258) LACK OF PATIENT COMPLIANCE COMPROMISES SAFETY OF VASECTOMY
Authors: Dr. Jana Wurzacher , Dr. Yannic Kunz , Dr. Tatjana Heisinger , Prof. Andreas Jungwirth , Prof. Germar-M Pinggera ,   On behalf of the Austrian Andrologic Workung Group of the Austrian Urologic Society
Published: July 2023

Objectives

Vasectomy is worldwide considered a cost-effective, definitive and safe method for male contraception and therefore one of the most frequently performed outpatient surgeries. However, repeated spermiogram controls to ascertain azoospermia are generally recommended to guarantee successful operation. This legal necessity, with all its implications, is noted in all signed informed consents basically to avert unjustified medical liability issues.

Methods

Members of the Austrian Andrological Working Group participate to this nationwide, retrospective data analysis for vasectomy in 2020. The primary aim was to investigate patients adherence/consultations according to the preoperative provided instructions. An anonymous dataset over 610 patients was analyzed.

Results

The mean patient age of was 41.60 years (SD 6.69), with the youngest male being 25 years old and the oldest male being 68 years old. A documented follow-up appointment for first spermiogram-analysis was scheduled for these patients in 96.89% (n=591), but, only 90.19% (n=533) attended to these appointments by achieving azoospermia in 86.00% (n=436). In 71 cases vital sperm could still be detected in the ejaculate (unknown in 26 cases). A second spermiogram control was scheduled for 87.24% (n=465 patients; unknown in 24 cases) and was attended by 392 patients (84.30% of patients), hereby azoospermia was achieved in 91.33% (n=358; unknown in 2 cases).

Complications such as hematoma, edema, or infection were reported in only 25 patients (4.10%). Failure to achieve sperm clearance was age-independent.

Conclusions

Although being a safe procedure with a low complication rate, post-vasectomy follow-up lacks extensive adherence. Roughly 10% of patients missed the required post-vasectomy controls and this regardless of the informed consent signed by the patient. Due to persisting oligozoospermia in 14% of patients after the first and 9% after the second follow-up visit, patients must be encouraged to attend the previously scheduled follow-up appointments. To guarantee a successful operation and safe contraception follow-up visits are crucial.

Conflicts of Interest

None
(48) SEXUAL HEALTH OF WOMEN IN UKRAINE IN THE TIME OF WAR
Authors: Prof. Viacheslav Grygorenko , Prof. Oksana Romashchenko , Dr. Valentyna Biloholovska , Prof. Sergii Melnykov , Dr. Liudmyla Yakovenko
Published: July 2023

Objectives

The study of the female sexual dysfunctions (FSD) frequency in women from unoccupied and occupied territories of Ukraine.

Methods

The sexological, gynecological and psychological studies have been carried out on 328 patients aged from 18 to 44. 242 women from unoccupied and 86 from occupied territories of the country were examined.

Results

The frequency of FSD among patients from 18 to 25 years old from unoccupied territories was 21 (8.7%) and among women from occupied territories – 25 (29.1%). Among women aged 26 to 35 from unoccupied territories the frequency of FSD amounted to 78 (32.2%) and among women of the same age from occupied territories – 39 (45.3%). When examining patients aged 36 and older from unoccupied territories the frequency of FSD constituted 29 (11.9%) and among women of the same age from the occupied territories – 16 (18.6%).

The frequency of FSD correlated with factor of stress amid military aggression, especially in the zone of hostilities and occupation, loss of relatives, violence, destruction, economic instability. Among FSD in both groups, sexual desire disorders prevailed: in 128 (52.9%) women from unoccupied and in 80 (93.1%) women from occupied territories. Moreover, the loss of sexual desire was found in 38 (15.7%) of those examined from unoccupied territories and 53 (61.6%) from occupied territories. Sexual disgust was noted by 6 (6.9%) of the examinees who experienced sexual violence in the occupied territory.

Conclusions

In Ukrainian women during the war in the spectrum of FSD, sexual desire disorders prevailed with the formation of sexual disgust in 6 (6.9%) examinees from occupied territories who were subjected to sexual violence. The frequency of FSD correlated with the stress factor arising from the experienced military occupation, loss of relatives, violence, destruction, economic instability.

Conflicts of Interest

No conflict of interest.
(263) SEXUAL COMPLAINTS IN PATIENTS FOLLOWED FOR ENDOMETRIOSIS
Authors: Ons Kaabia , Rim Bouchahda , Ryadh Ncibi , Khouloud Ikridih , Raouf Ben Abdesslem , Hedi Khairi
Published: July 2023

Objectives

Endometriosis is a disease specific to women which is largely under-diagnosed because it is often unrecognized in relation to painful symptomatology that is not very objective. It is characterized by cyclical pelvic pain concomitant with menstruation, but in some cases may present with complaints of a sexual nature. This work aims to report sexual complaints in patients with endometriosis and value them as elements of early diagnosis of this disease.

Methods

This is a cross-sectional descriptive study carried out on a series of young volunteer patients followed at the outpatient clinic of our unit for endometriosis confirmed either by imaging or by the anatomopathological study of biopsies carried out during laparoscopies. Participants answered a self-administered questionnaire.

Results

The study included 144 participants. The average age of the participants was 21.76 years with extremes ranging from 17 to 30 years. The average age of menarche was 12.25 with extremes ranging from 9 to 17 years. Sexual complaints were reported in 11 participants, i.e. in 7.64% of cases. Deep dyspareunia during intercourse accounted for 90.9% of sexual complaints. The pain was felt in certain positions and sexual practices, namely patient on the back or in the Andromaque position. Pain disturbed, prevented, or interrupted intercourse in 72.72% of cases with a decrease in desire and a disorder of secondary arousal and orgasm in respectively 27.27% and 36.36%.

Conclusions

Sexual complaints in patients with endometriosis remain infrequent under our skies but if they are present they are mainly of the type of deep dyspareunia altering the quality of sexual intercourse and may be responsible for secondary sexual dysfunctions.

Conflicts of Interest

Nothing to declare.
(255) REFUSAL OF MEDICAL CONTRACEPTION: FALSE HORMONOPHOBIA, TRUE LACK OF PLEASURE, THE DOUBT OF DIGITAL CONTRACEPTION
Authors: Dr. Danielle Choucroun
Published: July 2023

Objectives

We will highlight how the obligation of medical prescription to obtain oral contraception build a negativ representation of the pill by cognitive distorsion: hormonophobia is often cited to explain oral contraception refusal, but 2,2 millions of morning after pills (over-the-counter) are sold each year in France.(HRA-Pharma 07/2022) We want to expose that behind medical contraceptive refusal, we have to search sexual disorders such a lack of pleasure, couple's difficulties, sexual dysfunctions, even look for other antecedent.

Methods

Literature review on PubMed: keywords contraception-over-the counter; sexual desire and hormonal contraception General literature: Moles A. 1973 Théorie de l'information et perception esthétique. Younes C. PaquotT 2012 Espace et lieu dans la pensée occidentale Ed La Découverte General literature about media reports that in the ATAWAD era, anytime-anywhere-any device, the non accessibility to an object confers a representation and an imaginary of a dangerous product. We observe that many patients use App to control their fertility, and some of them had receive FDA clearance, but no independant scientific survey yet about them.

Results

Although decreased sexual desire is sometimes report with hormonal contraception, the causal link has not actually etablished. One study Novick AM & coll. Eur J Contracept Reprod Health Care 2022/06 questions the link between mood's side-effects of oral contraception and adverse childhood experiences.

Conclusions

We note that there is a common point between contraceptive refusal and the use of digital contraception: the limitation of sexual practices by the unwanted pregnancy risk. The action's means are: facilitate access to medical contraception, ask about history and sexual pleasure.

Conflicts of Interest

None
(325) WHEN PINK CLOUDS ARE ABSENT: LONG-TERM MATERNAL PSYCHOSOCIAL STRESS AFTER CARRYING AN UNINTENDED PREGNANCY TO TERM. FINDINGS FROM THE DUTCH PROSPECTIVE ABCD STUDY
Authors: Wieke Beumer , Prof. Tessa Roseboom , Dr. Marjette Koot , Dr. Tanja Vrijkotte , Dr. Jenneke van Ditzhuijzen
Published: July 2023

Objectives

Research into associations between unintended pregnancies carried to term and psychosocial stress (PS) postpartum is mixed, and especially evidence on long-term associations is scarce. In the current study, it is investigated whether carrying a unintended pregnancy to term is associated with maternal PS later in life, up to 12 years postpartum.

Methods

This study is based on the ongoing population-based birth cohort study ‘Amsterdam Born Children and their Development’ (ABCD-study) (n = 4,962). Unintended pregnancy was measured as a multidimensional construct, based on self-reported data on pregnancy mistiming, unwantedness, and unhappiness. Maternal PS was assessed using the STAI, CES-D and the DASS-21 around three months, five years and 11 years postpartum. Multiple SEM models were performed, examining the associations between dimensions of unintended pregnancy and maternal PS per time-point, while controlling for background variables and antepartum PS.

Results

Pregnancy mistiming and happiness were significant predictors of more maternal PS 3 months postpartum. Around 5 years postpartum, only pregnancy mistiming was positively associated to maternal PS. Dimensions of unintended pregnancy were no longer associated to maternal PS around 12 years postpartum.

Conclusions

Results reflect the multidimensionality of unintended pregnancy, suggesting long-term effects of dimensions of unintended pregnancy on maternal psychosocial stress, up to 5 years postpartum. People carrying a less intended pregnancy to term may benefit from extra support in the period after birth.

Conflicts of Interest

None.
(85) THE INFLUENCE OF SEXUAL AROUSAL & DISGUST ON PAIN
Authors: Lara Lakhsassi , Dr. Charmaine Borg , Prof. Peter J de Jong
Published: July 2023

Objectives

It have previously been demonstrated that inducing sexual arousal in the laboratory can modulate pain in men; but this effect has yet to be demonstrated in women. One explanation could be that for women, the erotic slides used to induce sexual arousal (SA) were not potent enough to elicit a lasting primed state of SA by the time pain was induced. Another explanation could be that disgust was inadvertently induced in women who viewed the erotic film. The current two studies will shed light on these questions.

Methods

Healthy female participants were randomly distributed across conditions and asked to view their respective film while using a cold pressor test (CPT). Visual analogue scales were used to measure pain intensity, and the time participants kept their hand in the cold water was used to measure pain tolerance.

CONDITIONS:

Study 1 (N = 151): SA (pornographic film), generalized arousal (parkour film), distraction (neutral film with counting task), control (neutral film without counting).

Study 2 (N = 174): SA (pornographic film), disgust (vomiting film), and control (neutral film). In Study 2, we also assessed whether the pornographic film may have inadvertently elicited disgust, potentially countering the pain modulatory effects that viewing the pornographic film might otherwise have had.

Results

Study 1: SA did not reduce subjective pain. Generalized arousal and distraction did not result in stronger analgesic effects than the neutral (baseline) condition.

Study 2: SA did not reduce subjective pain, but participants found the erotic stimulus, on average, nearly as disgusting as it was sexually arousing.

Conclusions

The findings do not support the hypothesis that SA modulates subjective pain in women as yet, but this may be due to the erotic stimulus eliciting disgust, which, in turn, may counter the pain modulatory effects that sexual arousal might otherwise have. A follow-up study will clarify this question.

Conflicts of Interest

None.
(208) TEMPERAMENT AND THE QUALITY OF SEXUAL LIFE OF POLISH WOMEN
Authors: Daria Jorg , Katarzyna Zborowska , Bożena Chrapkiewicz , Prof. Violetta Skrzypulec-Plinta
Published: July 2023

Objectives

The aim of the study was to characterize the sexual activity of women in early adulthood, based on the general quality of life and satisfaction with relationships, and to study the relationship between sexual functioning and satisfaction with it and temperamental variables.

Methods

The study involved 200 women aged 20 to 35 years. Data for the study were obtained using three standardized questionnaires: the Satisfaction With Life Scale (SWLS), the Sexual Satisfaction Questionnaire (KSS) and the Formal Characteristics of Behavior - Temperament Questionnaire in its revised version (FCZ-KT (R)) as well as the authorial tool: Short Characteristics of Sexual Activity (KCAS-J). The main part of the analysis covered relationships of temperament with sexual satisfaction, satisfaction with relationships and the overall quality of life in terms of the intensity of individual temperament features, the four basic temperament structures and the temperamental profiles occurring in the studied group.

Results

The highest levels of sexual satisfaction, relationship satisfaction and overall life satisfaction are achieved by people with a higher intensity of alertness, endurance and activity as well as the average level of intensity of perseverance and emotional reactivity. The lowest indicators of the level of sexual satisfaction, relationship satisfaction and overall life satisfaction are presented by people with the opposite temperamental characteristics: high rates of perseverance and emotional reactivity and, at the same time, lower than average levels of alertness, endurance and activity.

Conclusions

The conducted research allowed to notice significant relationships between the overall quality of life, the satisfaction with relationships, sexual satisfaction and temperamental variables in a group of women aged 20 to 35 years.

Conflicts of Interest

No Conflicts of Interest.
(66) SOCIO-SEXUAL BEHAVIORS AS A MODERN HUMAN PHENOMENON
Authors: Prof. Hajrullah Fejza , Prof. Ejona Icka , Prof. Xhevat Ukaj
Published: July 2023

Objectives

To measure the public opinion of different ages and sexes regarding their socio-sexual behaviors.

Methods

A qualitative descriptive research carried out through the survey of the Albanian population living in Kosovo and Albania. The data were collected in September 2002 through “The revised Sociosexual Orientation Inventory”, (Lars Penke). 712 people participated in the research (64.9% women and 34.1% men), of which 75.8% were aged 20-40. They were previously informed about the purpose of the research and the possibility of withdrawal.

Results

The obtained results showed that 52.5% had sex with only one partner, 14.6% had sex with two partners. 38.5% did not have sexual relations without interest in a long-term committed relationship with that person, with one partner 20.8% and with two such partners 12.1%. Sex without love is OK thought 40.2% which agreed or fully agreed, while 43% of them disagreed. When they were asked for the possibility to imagine themself comfortable and enjoy "casual" sex with different partners, 54.7% disagreed, 30.1% agreed, while 18.3% are undecided. When asked about the fantasy of having sex with someone with whom they are not in a committed romantic relationship, 22.5% stated never and 37.1% rarely. In the question, how often do you spontaneously fantasize about having sex with someone you just met, 34.8% stated never, while 34.3% said rarely, while only 9.8% said a few times a week

Conclusions

Based on these findings, we can conclude that even among Albanians there is a pronounced socio-sexual diversity.

Conflicts of Interest

Authors declared no conflict of interest
(95) GAY SEX AND THE GENDERED BRAIN. ARE BOTTOMS MORE FEM-BRAINED THAN TOPS? THE TBORNOTTB SURVEY OF 8,755 MEN
Authors: Herrero Rafael J , Aurélie Bourmaud , Priscilla Boizeau , Dr. Michel Ohayon
Published: July 2023

Objectives

The TBornotTB Survey set out to study the construction of the sexual anal positions (often termed “bottom”, “top”, and “versatile”) in men who have sex with men (MSM). This part of our study was to observe if personality traits traditionally considered gender-typical varied according to anal sexual identity (ASI) amongst MSM.

Methods

An on-line anonymous questionnaire (The TBornotTB Survey) was made available in the French language to all cisgender MSM of at least 18 years of age between June 25 and October 26 2020, including questions on personality traits traditionally associated with femininity or masculinity. Descriptive and analytical analyses were performed according to a statistical analysis plan drafted prior to the implementation of the study. Parametric or non-parametric tests were performed according to variable distribution. Statistical significance was set at 0.05.

Results

8,755 respondents met all the inclusion criteria for statistical analysis. 5,654 individuals responded to the questions concerning male-typical psychology (risk-taking, violence, sharing of feelings, spatial orientation and utilitarianism) and 5,651 responded to the questions concerning female-typical psychology (caring for others, consoling others, empathy, intuition and verbal capacity). In all the five categories associated with “female-typical” psychology, “bottoms” scored the lowest and “versatiles” scored the highest (e.g.- “Caring Category”: 78.3% “bottoms” agree vs 83.8% “versatiles”). In the five categories associated with “male-typical” psychology, “tops” scored the highest in all except in the category of risk-taking, where “bottoms” outscored the other two groups [“bottoms” like risk-taking (27.6%) vs. “tops” (22.7%] (p<0.01).

Conclusions

Our study is the largest study on this subject to date. The TBornotTB data suggest that there are psychological traits traditionally considered gender-typical that differ according to ASI. Nonetheless, our data counter the social assumption that “bottoms” hold a psychological make-up that is traditionally associated with femininity and give a scientific basis to oppose commonly held clichés.

Conflicts of Interest

No confict of interest to be declared.
(299) SHOW CASE OF EDUCATIONAL TOOLS FOR ADOLESCENT SEXUALITY - A WORK IN PROGRESS AT GENEVA UNIVERSITY AND HOSPITALS
Authors: Céline Brockmann , Priv-Doz. Jasmine Abdulcadir , Priv-Doz. Arnaud Merglen , Caroline Jacots-Decombes , Gabrielle Richard , Patricia Silveira , Maéva Badré , Nasteha Salah , Julien Da Costa , Romain Dewaele , Priv-Doz. Leen Aerts , Priv-Doz. Michal Yaron
Published: July 2023

Objectives

There are many misconceptions and taboos around sex, gender and sexuality that have a negative impact on sexual health. The Geneva University, Hospitals and Swiss Sexual Health, with the ministry of education have launched since 2017 an educational project, Science, Sex, Identity aiming at reducing sexual illiteracy. Using interdisciplinary, inclusive, sex-positive and evidence-based information, we have developed and shared trainings and pedagogical tools with teachers, health professionals, teenagers and their parents.

Methods

We have developed all our tools as an interdisciplinary scientific team with the contributions of our target audience: adolescents, young adults and adults, cisgender men and women, trans*and gender diverse individuals, intersex and dyadic people and women concerned with FGM/C.

Results

All our tools are available freely on our dedicated website: https://www.unige.ch/ssi

Conclusions

We have touched, with our multi-language tools, so far more than 200K people directly. We believe that dissemination of evidence-based sex-positive and inclusive knowledge at a young age can prevent sexual illiteracy. Thanks to online access, free to all, dedicated courses and tools can help mitigate sexual risk behavior and empower young people to live their sexuality to the fullest and improve their general well-being.

Conflicts of Interest

We have no conflict of interest.
(338) YOUNG PEOPLE'S PROPOSALS FOR A WEB-BASED INTERVENTION FOR SEXUAL HEALTH PROMOTION: A FRENCH QUALITATIVE STUDY
Authors: Philippe Martin , Prof. Corinne Alberti , Serge Gottot , Aurélie Bourmaud , Elise de La Rochebrochard
Published: July 2023

Objectives

Promoting sexual health is key to improving the supportive behaviors and well-being of young people. With the advent of the Internet, web-based features for sexual health promotion may be attractive to a diverse range of young people. This study aims to assess young people's proposals regarding a web-based intervention for sexual health promotion.

Methods

Nineteen French young people aged 15-24 years participated to the study. In a semi-structured interview, they presented their views on a web-based intervention for sexual promotion. Data were coded with N’Vivo and subjected to qualitative thematic analysis to explore their proposals.

Results

The majority of participants (n=18) thought that a web-based intervention for sexual health promotion would be attractive. Young people interviewed made 31 concrete proposals for sexual health promotion on the Internet. Participatory and interactive dimensions on the internet appeared essential, with the need for stimulating activities and interaction with peers, but also with competent professionals and moderation. Face to the risks of the internet, they expressed the need of a secure and confidential space, to generate trust and participation in intervention. For participants, sexual health should be addressed in all its dimensions, taking into account the relational, sexual, and gender dimensions, and by incrementing on the internet valid, credible and personalized content.

Conclusions

In sexual health promotion, young people are indispensable stakeholders who can make concrete proposals and can also participate in content creation and research. More broadly, in health promotion, involving target audiences in decisions represents a promising perspective.

Conflicts of Interest

No conflict of interest.
(259) SEXUAL DIFFICULTIES AMONG MEN WITH VIOLENT SEXUAL INTERESTS
Authors: Dr. Ellen Zakreski , Dr. Jim Pfaus , Dr. Klara Bartova , Dr. Lucie Krejcova , Dr. Renata Androvicova , Dr. Katerina Klapilova
Published: July 2023

Objectives

Individuals with paraphilic interests such as sexual interests in rape, masochism or violent restraint, may have difficulties establishing healthy, consensual intimate relationships. We aimed to examine whether adults with violent sexual interest have difficulties synchronizing with their partner or achieving orgasm during sexual intercourse.

Methods

A nationally representative sample of 1193 Czech adults completed an online survey examining paraphilic interest and sexual functioning. Participants were asked about their experience of sexual synchrony (harmonizing rhythm during intercourse, eye contact, noticing partner’s vocalization, etc.). For a variety of sexual positions, participants were asked how frequently they engaged in that position, how appealing they found that position, and the percentage of time they experienced orgasm in that position. Participants also reported the percentage of time they acheived orgasm via masturbation. Structural equation modeling with confirmatory factor analysis was then used to test associations between violent paraphilic interest, the probability of orgasm, frequency, and appeal across sexual positions, as well as sexual synchrony while controlling for age.

Results

In both men and women, greater sexual synchrony was associated with a greater probability of orgasm across a range of sexual positions, controlling for the appeal of a particular position and its frequency. In women, violent paraphilic interest was not significantly associated with orgasm probability or sexual synchrony. However, men with greater violent paraphilic interest experienced fewer orgasms across a range of positions, and this effect was mediated by reduced sexual synchrony. Violent paraphilic interest was not associated with the probability of orgasm via masturbation.

Conclusions

These results suggest that men with greater violent sexual interest may have difficulty experiencing pleasure in dyadic sexual activities. Difficulties experiencing orgasm or synchronizing with their partner during intercourse could lead individuals to develop more extreme sexual fantasies. Psychotherapy for individuals with violent paraphilic interests should take into consideration potential sexual problems.

Conflicts of Interest

None to declare.
Seroconversion following empiric praziquantel treatment as confirmatory diagnostic tool for chronic schistosomiasis
Authors: Marangoni Davide , Manciulli Tommaso , Barbiero Anna , Mantella Antonia , Spinicci Michele , Bartoloni Alessandro , Zammarchi Lorenzo
Published: July 2023

Highlight

We report on six patients with suspected chronic schistosomiasis and negative microbiological findings at baseline. All patients were treated empirically with praziquantel and all seroconverted 20 days to two months after treatment. We suggest that seroconversion after praziquantel treatment may be used as a confirmatory diagnostic tool for chronic schistosomiasis.
A novel high-resolution melting analysis strategy for detecting cystic fibrosis–causing variants
Authors: Díez Rodríguez Gerardo Raúl , Figueredo Lago Juan Emilio , Armas Cayarga Anny , González González Yaimé Josefina , García de la Rosa Iria , Collazo Mesa Teresa , López Reyes Ixchel , Batista Lozada Yulaimy , Rodríguez Calá Fidel Ramón , García Sánchez Juan Bautista
Published: July 2023

Cystic fibrosis (CF), an autosomal recessive disease, is caused by variants in both alleles of the CF transmembrane conductance regulator (CFTR) gene. A new assay based on allele-specific polymerase chain reaction and high-resolution melting analysis was developed for the detection of 18 CF-causing CFTR variants previously identified in Cuba and Latin America. The assay is also useful for zygosity determination of mutated alleles and includes internal controls. The reaction mixtures were normalized and evaluated using blood samples collected on filter paper. The evaluation of analytical parameters demonstrated the specificity and sensitivity of the method to detect the included CFTR variants. Internal and external validations yielded a 100% agreement between the new assay and the used reference tests. This assay can complement CF newborn screening not only in Cuba but also in Latin America.
Healthcare Services for Asylum-Seekers: Untangling the European Social Charter
Authors: Litins’ka Yana
Published: July 2023

Asylum-seekers, like any population, need healthcare services, yet national laws sometimes restrict access to such services. The European Social Charter (revised) protects the right to health and medical services. However, the Charter has a complex application, and its scope is limited concerning foreigners. This article analyses to what extent the provisions of the Charter on the right to health and medical assistance apply to adult asylum-seekers. It shows that the Charter may apply to various degrees to asylum-seekers depending on several circumstances, such as the national definition of residence or regular work, grounds for seeking asylum, citizenship or lack thereof. Depending on these factors, some asylum-seekers may receive full healthcare services, whereas others may have only limited rights. The article shows that the migrant statuses created by national and EU law do not fit in the system of statuses in the Charter, which might produce legal hindrances to accessing health-related rights for asylum-seekers. The article also discusses the possible ways for the European Committee of Social Rights to further expand the scope of the Charter’s application.