bluuebunny/crossref_metadata_2025 huggingface dataset:
Toward a Compassionate Intersectional Neuroscience: Increasing Diversity and Equity in Contemplative Neuroscience
Authors: Weng Helen Y. , Ikeda Mushim P. , Lewis-Peacock Jarrod A. , Chao Maria T. , Fullwiley Duana , Goldman Vierka , Skinner Sasha , Duncan Larissa G. , Gazzaley Adam , Hecht Frederick M.
Published: November 2020

Mindfulness and compassion meditation are thought to cultivate prosocial behavior. However, the lack of diverse representation within both scientific and participant populations in contemplative neuroscience may limit generalizability and translation of prior findings. To address these issues, we propose a research framework calledIntersectional Neurosciencewhich adapts research procedures to be more inclusive of under-represented groups. Intersectional Neuroscience builds inclusive processes into research design using two main approaches: 1) community engagement with diverse participants, and 2) individualized multivariate neuroscience methods to accommodate neural diversity. We tested the feasibility of this framework in partnership with a diverse U.S. meditation center (East Bay Meditation Center, Oakland, CA). Using focus group and community feedback, we adapted functional magnetic resonance imaging (fMRI) screening and recruitment procedures to be inclusive of participants from various under-represented groups, including racial and ethnic minorities, gender and sexual minorities, people with disabilities, neuropsychiatric disorders, and/or lower income. Using person-centered screening and study materials, we recruited and scanned 15 diverse meditators (80% racial/ethnic minorities, 53% gender and sexual minorities). The participants completed the EMBODY task – which applies individualized machine learning algorithms to fMRI data – to identify mental states during breath-focused meditation, a basic skill that stabilizes attention to support interoception and compassion. All 15 meditators’ unique brain patterns were recognized by machine learning algorithms significantly above chance levels. These individualized brain patterns were used to decode the internal focus of attention throughout a 10-min breath-focused meditation period, specific to each meditator. These data were used to compile individual-level attention profiles during meditation, such as the percentage time attending to the breath, mind wandering, or engaging in self-referential processing. This study provides feasibility of employing an intersectional neuroscience approach to include diverse participants and develop individualized neural metrics of meditation practice. Through inclusion of more under-represented groups while developing reciprocal partnerships, intersectional neuroscience turns the research process into an embodied form of social action.
Developmental Effects of Davydov’s Mathematics Curriculum in Relation to School Readiness Level and Teacher Experience
Authors: Sidneva Anastasia
Published: November 2020

Davydov’s mathematics curriculum was designed according to the principles of the Cultural Historical Activity Theory (CHAT). In this study, we analyzed some developmental effects of its realization in Grade 1 (N = 46, two classes), in relation to the children’s school readiness level (specifically, their motivation, voluntary regulation, and intellectual development), and their teacher’s experience (a very experienced teacher in one class, and a less experienced one in the other). We assessed two groups of developmental effects: (1) some general math abilities (comparison of objects, measurement and ability to solve simple problems of addition and subtraction); and (2) some abilities, which are very specific to Davydov’s mathematics curriculum (i.e., the ability to put numbers on a number line and to measure quantity using different measures). At the beginning of the Grade 1, we divided all participants into three groups according to their level of motivation (low, medium, or high), voluntary regulation (low, medium, or high), and logical preservation (low, medium, or high) in terms of J. Piaget. After 1 year (at the beginning of Grade 2) we measured general effects again and also measured specific effects. The results showed that all the children became significantly better in all general math abilities. It was also found that progress in math abilities does not depend on the initial level of school readiness of children. Children with different levels of voluntary regulation, motivational readiness, and the level of logical preservation show improvements in general math abilities. As for the mathematical skills specific to the Davydov’ program, the achieved level of their development (both according to the test results and the results of the expert assessment by the teacher) is also not related to the initial parameters of readiness for school. Also, there were no differences in improvements in general effects and in specific effects between the classes with experienced and not-so-experienced teacher. So, there are some reasons to believe that the level of the child’s actual development does not play a fundamental role for education, which built in accordance with the principles of CHAT.
A Mission Concept to Determine the Magnetospheric Causes of Aurora
Authors: Borovsky Joseph E. , Delzanno Gian Luca , Henderson Michael G.
Published: November 2020

Insufficiently accurate magnetic-field-line mapping between the aurora and the equatorial magnetosphere prevents us from determining the cause of many types of aurora. An important example is the longstanding question of how the magnetosphere drives low-latitude (growth-phase) auroral arcs: a large number of diverse generator mechanisms have been hypothesized but equatorial magnetospheric measurements cannot be unambiguously connected to arcs in the ionosphere, preventing the community from identifying the correct generator mechanisms. Here a mission concept is described to solve the magnetic-connection problem. From an equatorial instrumented spacecraft, a powerful energetic-electron beam is fired into the atmospheric loss cone resulting in an optical beam spot in the upper atmosphere that can be optically imaged from the ground, putting the magnetic connection of the equatorial spacecraft’s measurements into the context of the aurora. Multiple technical challenges that must be overcome for this mission concept are discussed: these include spacecraft charging, beam dynamics, beam stability, detection of the beam spot in the presence of aurora, and the safety of nearby spacecraft.
Biofortification of Common Bean for Higher Iron Concentration
Authors: Beebe Stephen
Published: November 2020

Common bean (Phaseolus vulgaris L.) is a staple food of smallholder farmers and poor urban consumers in Latin America and eastern-southern Africa among whom iron deficiency is frequent. Bean was domesticated in Mexico and the southern Andes, creating two distinct gene pools. Evaluation of a core collection of 1,441 entries revealed average concentrations of 55 mg kg−1 iron. A breeding target was set at 44 mg kg−1 iron above the level in a local check variety, while 50% of goal or a 22 mg kg−1 advantage was accepted as “biofortified.” In a bioefficacy trial among college-age women in Rwanda, high iron beans improved iron status and enhanced cognitive ability, brain function, and work efficiency. However, breeding progress has been slow, likely due in part to homeostatic mechanisms whereby organisms moderate iron and zinc uptake. This phenomenon may represent resistance to increasing concentration of these elements. Crosses between gene pools may “jumble” genes for homeostasis and permit high levels. A second breeding strategy is the use of sister species that evolved in iron-poor environments and that could be more receptive to iron uptake. Future breeding may also increase attention on improving bioavailability through mechanisms such as non-or-slow darkening grain or low phytate mutants. Changing dietary patterns in developed countries could increase iron deficiency and create demand for iron biofortified beans.
Testing Different Deterrents as Candidates for Short-Term Reduction in Wild Boar Contacts—A Pilot Study
Authors: Denzin Nicolai , Helmstädt Frithjof , Probst Carolina , Conraths Franz J.
Published: November 2020

African swine fever (ASF) is a viral infection of pigs and represents a major threat to animal health and trade. Due to the high tenacity of the causative virus in carcasses of wild boar, contacts of wild boar with infectious carcasses are regarded an important driver of the so-called habitat cycle. The latter is believed to play a major role in maintaining the present ASF situation in wild boar in Europe. Therefore, search campaigns and timely removal and disposal of carcasses are considered important disease control approaches. If timely disposal is not feasible due to logistic reasons, deterrence of wild boar may be a provisionary option. The performance of seven deterrents (physical and chemical) was tested in a forest near Greifswald, Germany. Carcasses as entities of attraction for wild boar were substituted by luring sites. It could be demonstrated in this pilot study that certain physical (LED blinkers, aluminum strips) and chemical (HAGOPUR Wildschwein-Stopp™, Hukinol™) deterrents are capable of reducing the odds of wild boar contacts to one third, but in depth testing of the aforementioned promising deterrent candidates is recommended. A choice of those deterrents identified as suitable, reasonable, and easy to apply should be carried out, when carcass search campaigns are launched in the case of an outbreak of ASF in wild boar.
Phage Therapy: Towards a Successful Clinical Trial
Authors: Górski Andrzej , Borysowski Jan , Międzybrodzki Ryszard
Published: November 2020

While phage therapy carried out as compassionate use (experimental therapy) has recently flourished, providing numerous case reports of supposedly healed patients, clinical trials aiming to formally prove their value in accord with current regulatory requirements have failed. In light of the current issue of increasing antibiotic resistance, the need for a final say regarding the place of phage therapy in modern medicine is evident. We analyze the possible factors that may favor success or lead to the failure of phage therapy: quality of phage preparations, their titer and dosage, as well as external factors that could also contribute to the outcome of phage therapy. Hopefully, better control of these factors may eventually bring about long-awaited positive results.
Mutual Interference of Local Gravity Wave Forcings in the Stratosphere
Authors: Samtleben Nadja , Kuchař Aleš , Šácha Petr , Pišoft Petr , Jacobi Christoph
Published: November 2020

Gravity wave (GW) breaking and associated GW drag is not uniformly distributed among latitudes and longitudes. In particular, regions of enhanced GW breaking, so-called GW hotspots, have been identified, major Northern Hemisphere examples being located above the Rocky Mountains, the Himalayas and the East Asian region. These hotspots influence the middle atmosphere circulation both individually and in combination. Their interference is here examined by performing simulations including (i) the respective single GW hotspots, (ii) two GW hotspots, and (iii) all three GW hotspots with a simplified global circulation model. The combined GW hotspots lead to a modification of the polar vortex in connection with a zonal mean flow decrease and an increase of the temperature at higher latitudes. The different combinations of GW hotspots mainly prevent the stationary planetary wave (SPW) 1 from propagating upward at midlatitudes leading to a decrease in energy and momentum transfer in the middle atmosphere caused by breaking SPW 1, and in turn to an acceleration of the zonal mean flow at lower latitudes. In contrast, the GW hotspot above the Rocky Mountains alone causes an increase in SPW 1 amplitude and Eliassen–Palm flux (EP flux), inducing enhanced negative EP divergence, decelerating the zonal mean flow at higher latitudes. Consequently, none of the combinations of different GW hotspots is comparable to the impact of the Rocky Mountains GW hotspot alone. The reason is that the GW hotspots mostly interfere nonlinearly. Depending on the longitudinal distance between two GW hotspots, the interference between the combined Rocky Mountains and East Asian GW hotspots is more additive than the interference between the combined Rocky Mountains and Himalaya GW hotspots. While the Rocky Mountains and the East Asian GW hotspots are longitudinally displaced by 105°, the Rocky Mountains are shifted by 170° to the Himalayas. Moreover, while the East Asian and the Himalayas are located side by side, the interference between these GW hotspots is the most nonlinear because they are latitudinally displaced by 20°. In general, the SPW activity, e.g., represented in SPW amplitudes, EP flux or Plumb flux, is strongly reduced, when the GW hotspots are interacting with each other. Thus, the interfering GW hotspots mostly have a destructive effect on SPW propagation and generation.
Antimicrobial Potential of Beverages Preparation Based on Fermented Milk Permeate and Berries/Vegetables
Authors: Zokaityte Egle , Lele Vita , Starkute Vytaute , Zavistanaviciute Paulina , Ruzauskas Modestas , Mozuriene Erika , Cepiene Marina , Ceplinskas Vidas , Kairaityte Gintare , Lingyte Rasa , Marciulionis Laurynas , Monstaviciute Ema , Pikunaite Meda , Smigelskyte Migle , Vyzaite Enrika , Zilinskaite Laima , Ruibys Romas , Bartkiene Elena
Published: November 2020

Nowadays, taking into consideration the current dynamics of drug resistance development, many researchers are working to develop new antimicrobial compound combinations for the food and beverage industry, which can overcome this problem. The aim of this study was to evaluate the antimicrobial properties of milk permeate fermented with Lactobacillus plantarum LUHS135, Lactobacillus plantarum LUHS122, and Lactobacillus faraginis LUHS206 strains in combination with berry/vegetable (B/V) pomace (gooseberries, chokeberries, cranberries, sea buckthorn, rhubarb) against a variety of pathogenic strains (methicillin-resistant Staphylococcus aureus, Citrobacter freundii, Klebsiella pneumoniae, Salmonella enterica, Bacillus cereus, Pseudomonas aeruginosa, Acinetobacter baumanni, Proteus mirabilis, Enterococcus faecalis, Enterococcus faecium, Streptococcus mutans, Streptococcus epidermis, Staphylococcus haemolyticus, Pasteurella multocida, and Enterobacter cloacae) as a potential antimicrobial combination for beverage preparation. The highest number of the tested pathogenic strains was inhibited by gooseberries, sea buckthorn, and rhubarb combinations with strain LUHS122 fermented beverages (13 pathogens out of 15 tested). Twelve out of 15 tested pathogens were inhibited by gooseberry combinations with LUHS135 and LUHS206 fermented milk permeate. Selected B/V in combination with fermented milk permeate are promising antimicrobial ingredients for beverage preparation, possessing antimicrobial activity almost against all the tested pathogenic strains.
Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients
Authors: Matsuki Takashi , Okamoto Isaku , Fushimi Chihiro , Takahashi Hideaki , Okada Takuro , Kondo Takahito , Sato Hiroki , Ito Tatsuya , Tokashiki Kunihiko , Tsukahara Kiyoaki , Hanyu Kenji , Masubuchi Tatsuo , Tada Yuichiro , Miura Kouki , Omura Go , Sawabe Michi , Kawakita Daisuke , Yamashita Taku
Published: November 2020

No real-world, long-term outcomes of immunotherapy with nivolumab for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) have yet been reported. Furthermore, the prognostic impact of the best overall response (BOR) of this therapy remains unclear. We conducted a multi-institutional cohort study of the long-term efficacy and safety of this therapy and investigated prognostic factors associated with survival. Further, we evaluated the relationship between BOR and survival. Median follow-up time was 25.9 months. Median overall survival (OS) was 9.6 months, and two-year survival rate was 25.0%. Median progression-free survival (PFS) was 3.7 months, and two-year PFS rate was 19.6%. BOR was assessed as complete response (CR) in 6%, partial response (PR) in 13%, stable disease (SD) in 30%, and progressive disease (PD) in 52% of the patients. Overall response rate was 18%, and disease control rate was 48%. For immune-related adverse events (irAEs), 38 irAEs were detected in 29 patients. On multivariate analysis, the development of irAEs was significantly associated with better OS and PFS. Better BOR was significantly associated with longer OS and PFS. These findings demonstrate the long-term efficacy and safety of nivolumab therapy for R/M SCCHN in a real-world setting. The magnitude of BOR and the development of irAEs might be useful surrogate markers of survival.
Carcinoma-Associated Fibroblasts Promote Growth of Sox2-Expressing Breast Cancer Cells
Authors: Dittmer Angela , Dittmer Jürgen
Published: November 2020

CAFs (Carcinoma-associated fibroblasts) play an important role in cancer progression. For instance, they promote resistance to anti-estrogens, such as fulvestrant. Here, we show that, in ERα-positive breast cancer cell lines, the cocktail of factors secreted by CAFs (CAF-CM) induce the expression of the embryonal stem cell transcription factor Sox2 (sex determining region Y (SRY)-box 2). Long-term exposure to CAF-CM was able to give rise to very high Sox2 levels both in the absence and presence of fulvestrant. IL-6 (interleukin-6), a major component of CAF-CM, failed to raise Sox2 expression. In MCF-7 sublines established in the presence of CAF-CM, almost all cells showed Sox2 expression, whereas long-term treatment of T47D cells with CAF-CM resulted in a ~60-fold increase in the proportions of two distinct populations of Sox2 high and low expresser cells. Exposure of BT474 cells to CAF-CM raised the fraction of Sox2 high expresser cells by ~3-fold. Cell sorting based on CD44 and CD24 expression or ALDH (aldehyde dehydrogenase) activity revealed that most Sox2 high expresser cells were not CD44hi/CD24lo- or ALDH-positive cells suggesting that they were not CSCs (cancer stem cells), though CD44 played a role in Sox2 expression. Functionally, Sox2 was found to protect CAF-CM-treated cells against apoptosis and to allow higher growth activity in the presence of fulvestrant. Mechanistically, the key drivers of Sox2 expression was found to be STAT3 (Signal transducer and activator of transcription 3), Bcl-3 (B-cell lymphoma 3) and the PI3K (Phosphoinositide 3-kinase)/AKT pathway, whose activities/expression can all be upregulated by CAF-CM. These data suggest that CAF-CM induces Sox2 expression in non-CSCs by activating proteins involved in growth control and drug resistance, leading to higher protection against apoptosis.
Small Bowel Adenocarcinomas Featuring Special AT-Rich Sequence-Binding Protein 2 (SATB2) Expression and a Colorectal Cancer-Like Immunophenotype: A Potential Diagnostic Pitfall
Authors: Neri Giuseppe , Arpa Giovanni , Guerini Camilla , Grillo Federica , Lenti Marco Vincenzo , Giuffrida Paolo , Furlan Daniela , Sessa Fausto , Quaquarini Erica , Viglio Alessandra , Ubezio Cristina , Pasini Alessandra , Ferrero Stefano , Sampietro Gianluca , Ardizzone Sandro , Latella Giovanni , Mescoli Claudia , Rugge Massimo , Zingone Fabiana , Barresi Valeria , Ciccocioppo Rachele , Pedrazzoli Paolo , Corazza Gino Roberto , Luinetti Ombretta , Solcia Enrico , Paulli Marco , Di Sabatino Antonio , Vanoli Alessandro
Published: November 2020

Special AT-rich sequence-binding protein 2 (SATB2) is a transcription factor expressed by colonic cryptic epithelium and epithelial neoplasms of the lower gastrointestinal (GI) tract, as well as by small bowel adenocarcinomas (SBAs), though at a lower rate. Nevertheless, up to now, only small SBA series, often including a very limited number of Crohn’s disease-associated SBAs (CrD-SBAs) and celiac disease-associated SBAs (CD-SBA), have been investigated for SATB2 expression. We evaluated the expression of SATB2 and other GI phenotypic markers (cytokeratin (CK) 7 and CK20, caudal type homeobox 2 (CDX2) and alpha-methylacyl-CoA racemase (AMACR)), as well as mismatch repair (MMR) proteins, in 100 SBAs, encompassing 34 CrD-SBAs, 28 CD-SBAs and 38 sporadic cases (Spo-SBAs). Any mutual association and correlation with other clinico-pathologic features, including patient prognosis, were searched. Twenty (20%) SATB2-positive SBAs (4 CrD-SBAs, 7 CD-SBAs and 9 Spo-SBAs) were identified. The prevalence of SATB2 positivity was lower in CrD-SBA (12%) in comparison with both CD-SBAs (25%) and Spo-SBAs (24%). Interestingly, six SBAs (two CD-SBAs and four Spo-SBAs) displayed a full colorectal carcinoma (CRC)-like immunoprofile (CK7−/CK20+/CDX2+/AMACR+/SATB2+); none of them was a CrD-SBA. No association between SATB2 expression and MMR status was observed. Although SATB2-positive SBA patients showed a more favorable outcome in comparison with SATB2-negative ones, the difference did not reach statistical significance. When cancers were stratified according to CK7/CK20 expression patterns, we found that CK7−/CK20- SBAs were enriched with MMR-deficient cases (71%) and patients with CK7−/CK20− or CK7−/CK20+ SBAs had a significantly better survival rate compared to those with CK7+/CK20− or CK7+/CK20+ cancers (p = 0.002). To conclude, we identified a small (6%) subset of SBAs featuring a full CRC-like immunoprofile, representing a potential diagnostic pitfall in attempts to identify the site of origin of neoplasms of unknown primary site. In contrast with data on colorectal carcinoma, SATB2 expression is not associated with MMR status in SBAs. CK patterns influence patient survival, as CK7−/CK20− cancers show better prognosis, a behavior possibly due to the high rate of MMR-deficient SBAs within this subgroup.
Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia
Authors: Mostazo Miriam G. Contreras , Kurrle Nina , Casado Marta , Fuhrmann Dominik , Alshamleh Islam , Häupl Björn , Martín-Sanz Paloma , Brüne Bernhard , Serve Hubert , Schwalbe Harald , Schnütgen Frank , Marin Silvia , Cascante Marta
Published: November 2020

Tyrosine kinase inhibitors (TKIs) are currently the standard chemotherapeutic agents for the treatment of chronic myeloid leukemia (CML). However, due to TKI resistance acquisition in CML patients, identification of new vulnerabilities is urgently required for a sustained response to therapy. In this study, we have investigated metabolic reprogramming induced by TKIs independent of BCR-ABL1 alterations. Proteomics and metabolomics profiling of imatinib-resistant CML cells (ImaR) was performed. KU812 ImaR cells enhanced pentose phosphate pathway, glycogen synthesis, serine-glycine-one-carbon metabolism, proline synthesis and mitochondrial respiration compared with their respective syngeneic parental counterparts. Moreover, the fact that only 36% of the main carbon sources were utilized for mitochondrial respiration pointed to glycerol-phosphate shuttle as mainly contributors to mitochondrial respiration. In conclusion, CML cells that acquire TKIs resistance present a severe metabolic reprogramming associated with an increase in metabolic plasticity needed to overcome TKI-induced cell death. Moreover, this study unveils that KU812 Parental and ImaR cells viability can be targeted with metabolic inhibitors paving the way to propose novel and promising therapeutic opportunities to overcome TKI resistance in CML.
Multidisciplinary Clinical Approach to Cancer Patients with Immune-Related Adverse Events Induced by Checkpoint Inhibitors
Authors: Londoño Maria-Carlota , Reig Maria ,   on behalf of the RETOINMUNO Multidisciplinary Group
Published: November 2020

Immune-oncology is a major breakthrough in cancer treatment and has become the standard of care for a wide variety of solid organ malignancies. Unfortunately, manipulation of the immune system with checkpoint inhibitors may result in an immune-based attack of normal tissues which can lead to treatment discontinuation. These immune-related adverse events (irAEs) are diverse and affect several organs, constituting a new clinical challenge in the management of cancer patients. The complexity of this scenario requires a multidisciplinary approach that allows the early identification, diagnosis and treatment of specific irAE, ruling out other non-related adverse events. Hospital Clinic has a multidisciplinary team seeking to develop a coordinated strategy to facilitate the access of patients with suspected irAEs to specialised care resulting in harmonised management that guarantees the best patient care. The aim of the manuscript was to describe the current evidence on the management of irAEs reflecting a coordinated multidisciplinary approach to face this clinical challenge regardless of the immunotherapy indication.
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells
Authors: Ristori Emma , Cicaloni Vittoria , Salvini Laura , Tinti Laura , Tinti Cristina , Simons Michael , Corti Federico , Donnini Sandra , Ziche Marina
Published: November 2020

The amyloid-β precursor protein (APP) is a ubiquitous membrane protein often associated with Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA). Despite its role in the development of the pathogenesis, APP exerts several physiological roles that have been mainly investigated in neuronal tissue. To date, the role of APP in vasculature and endothelial cells has not been fully elucidated. In this study, we used molecular and proteomic approaches to identify and investigate major cellular targets of APP down-regulation in endothelial cells. We found that APP is necessary for endothelial cells proliferation, migration and adhesion. The loss of APP alters focal adhesion stability and cell–cell junctions’ expression. Moreover, APP is necessary to mediate endothelial response to the VEGF-A growth factor. Finally, we document that APP propagates exogenous stimuli and mediates cellular response in endothelial cells by modulating the Scr/FAK signaling pathway. Thus, the intact expression and processing of APP is required for normal endothelial function. The identification of molecular mechanisms responsible for vasoprotective properties of endothelial APP may have an impact on clinical efforts to preserve and protect healthy vasculature in patients at risk of the development of cerebrovascular disease and dementia including AD and CAA.
Influence of Al and N Content and Cooling Rate on the Characteristics of Complex MnS Inclusions in AHSS
Authors: Nabeel Muhammad , Alba Michelia , Dogan Neslihan
Published: November 2020

This study focused on the characteristics of complex MnS inclusions in advanced high strength steels. The effect of metal chemistry (Al and N) and the cooling rate of steel were evaluated by analyzing the inclusions present in five laboratory produced steels. The observed complex MnS inclusions contained Al2O3-MnS, AlN-MnS, and AlON-MnS. An increase in Al content from 0.5% to 6% increased the number of complex MnS inclusions by ~4 times. In comparison, a decrease of ~80% was observed due to the increased N content of steel from <10 ppm to ~50 ppm. MnS precipitation ratio was used to determine the potency of different inclusions forming complex MnS inclusions due to heterogeneous nucleation. It was found that the MnS precipitation ratio of the observed inclusions was related to their misfit with MnS, and it decreased in the order of AlN > AlON > Al2O3. Moreover, it was determined that AlN particles could be easily engulfed at the solidification front relative to Al2O3, which resulted in a higher MnS precipitation ratio for Al2O3 under slow cooling conditions.
Molecular Dynamics Simulation of CO2 Diffusion in a Carbonated Water–Decane System
Authors: Yuan Lei , Zhao Changzhong , Xu Yongsheng , Zhang Yi
Published: November 2020

Carbonated water injection (CWI) is a technology with significant sweep efficiency advantages in enhanced oil recovery (EOR), but the mechanism of the microscopic diffusion of CO2 is still unclear. In this study, the diffusion mechanism of CO2 from the aqueous phase to the oleic phase in a carbonated water (CW)–decane system was investigated by the molecular dynamics simulation method. This investigation also explored the diffusion capacity and interface properties of the CW–decane system. We found that the movement of CO2 from the aqueous phase to the oleic phase can be divided into two processes: the accumulation behavior of CO2 moving from the aqueous phase to the interface, and the dissolution behavior of CO2 moving from the interface to the decane phase. The increase in the temperature and CO2 concentration in carbonated water can improve the decane phase’s diffusion ability and reduce the water–decane interfacial tension. The difference in the interactions between water–CO2 and decane–CO2 provides a driving force for the diffusion of CO2 between aqueous and oleic phase. The temperature increase intensifies the degree of diffusion and improves the diffusion rate of CO2 from the aqueous phase to the oleic phase. The diffusion coefficient results show that CO2 significantly enhances the oleic phase’s diffusion properties. In addition, the affinity of water for CO2 is increased by the hydrogen bond, and it provides a mechanism for the accumulation behavior of CO2. Further, the temperature significantly improves the CO2 diffusion ability at the interface, which promotes CO2 leaving the interface and weakens the accumulation behavior. This work provides useful information for guiding carbonated water injection to improve the recovery mechanism of enhanced oil.
A One-Month Monitoring of Exposure to Solar UV Radiation of a Group of Construction Workers in Tuscany
Authors: Modenese Alberto , Gobba Fabriziomaria , Paolucci Valentina , John Swen Malte , Sartorelli Pietro , Wittlich Marc
Published: November 2020

Solar radiation exposure at work is a relevant heath risk in the construction sector. Our objective was to monitor for a full month the individual solar ultraviolet radiation (UVR) exposure of a group of three construction workers active in Siena (latitude = 43°19′ N), a town in Tuscany (Italy). We used personal electronic dosimeters “X-2012-10” (Gigahertz, Turkenfeld, Germany) to register the UV irradiance in the UVA and UVB/C regions separately and we consulted a specific database to retrieve the corresponding ambient erythemal UVR dose (cloud-free conditions). In spring, construction workers from central Italy received a quite variable UVR dose, between 0.9 standard erythemal doses (SED) and 15.6 SED/day, 5.7 on average. Considering the proportion with respect to the potential environmental exposure, personal exposure resulted between 2.7% and 31.2% of the ambient erythemal dose, with a mean value of 12.5%. Cumulatively, the three construction workers received in one working month a UVR dose of more than 120 SED. In a year, we estimated that a construction worker from Tuscany region is exposed to about 750 SED. This data demonstrates that construction workers in Italy are exposed to extremely high levels of solar UVR, with a relevant risk of developing adverse health effects related to the potential accumulation of UVR-induced damage in susceptible biological tissues, such as the skin and the eyes.
On Reduced Consumption of Fossil Fuels in 2020 and Its Consequences in Global Environment and Exergy Demand
Authors: Rashedi A. , Khanam Taslima , Jonkman Mirjam
Published: November 2020

As the world grapples with the COVID-19 pandemic, there has been a sudden and abrupt change in global energy landscape. Traditional fossil fuels that serve as the linchpin of modern civilization have found their consumption has rapidly fallen across most categories due to strict lockdown and stringent measures that have been adopted to suppress the disease. These changes consequently steered various environmental benefits across the world in recent time. The present article is an attempt to investigate these environmental benefits and reversals that have been materialized in this unfolding situation due to reduced consumption of fossil fuels. The life cycle assessment tool was used hereby to evaluate nine environmental impacts and one energy based impact. These impacts include ozone formation (terrestrial ecosystems), terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial ecotoxicity, freshwater ecotoxicity, marine ecotoxicity, land use, mineral resources scarcity, and cumulative exergy demand. Outcomes from the study demonstrate that COVID-19 has delivered impressive changes in global environment and life cycle exergy demand, with about 11–25% curtailment in all the above-mentioned impacts in 2020 in comparison to their corresponding readings in 2019.
Implementation of the Indoor Environmental Quality (IEQ) Model for the Assessment of a Retrofitted Historical Masonry Building
Authors: Piasecki Michał , Radziszewska-Zielina Elżbieta , Czerski Piotr , Fedorczak-Cisak Małgorzata , Zielina Michał , Krzyściak Paweł , Kwaśniewska-Sip Patrycja , Grześkowiak Wojciech
Published: November 2020

Achieving a satisfactory level for indoor environments of historical buildings is an ongoing problem that needs to be solved due to a large demand for deep retrofits in the whole of Europe. The implementation of the indoor environmental quality index (IEQ) to predict an occupant’s satisfaction in thermo-modernized historical buildings is a new concept which is a response to existing needs. In this article, a relevant study is provided with the intention to evaluate the indoor environmental performance of retrofitting effects in historical buildings dating back to the years 1873–1878. Considering the historical character of the buildings, some of the cellar spaces were fitted out with an innovative internal insulation system of mineral sheets based on calcium silicate to prevent water vapor condensation and effectively limit mold growth. The IEQ methodology was applied for retrofitted and non-retrofitted spaces as a comparison. Four essential components of indoor quality are investigated: thermal comfort, indoor air quality, acoustic comfort, and visual quality. The results of sub-component indexes are calculated based on the measured indoor parameters and the specific sensory functions. This paper discusses the results of an indoor environmental analysis including a mycological air quality assessment with the newly developed IAQindex (fungal air contamination index), total volatile organic compound concentration (TVOC), CO2, and formaldehyde (HCHO) assessment, the evaluation energy-related thermal comfort, acoustic, and visual quality, of modernized spaces. A questionnaire survey study was additionally carried out among a building’s users intentioned to compare the accounts of satisfaction before and after the retrofitting process and also to compare “subjective” results with the one’s based on in situ tests. The retrofitting approach was proven to be effective in limiting the presence of molds and a significant difference in indoor environmental quality between thermally insulated and uninsulated spaces was observed and discussed.
The Enhancement of Energy Efficiency in a Wastewater Treatment Plant through Sustainable Biogas Use: Case Study from Poland
Authors: Masłoń Adam , Czarnota Joanna , Szaja Aleksandra , Szulżyk-Cieplak Joanna , Łagód Grzegorz
Published: November 2020

The improvement of energy efficiency ensuring high nutrients removal is a great concern for many wastewater treatment plants (WWTPs). The energy balance of a WWTP can be improved through the application of highly efficient digestion or its intensification, e.g., through the introduction of the co-substrates with relatively high energy potential to the sewage sludge (SS). In the present study, the overview of the energetic aspect of the Polish WWTPs was presented. The evaluation of energy consumption at individual stages of wastewater treatment along with the possibilities of its increasing was performed. Additionally, the influence of co-digestion process implementation on the energy efficiency of a selected WWTP in Poland was investigated. The evaluation was carried out for a WWTP located in Iława. Both energetic and treatment efficiency were analyzed. The energy balance evaluation of this WWTP was also performed. The obtained results indicated that the WWTP in Iława produced on average 2.54 GWh per year (7.63 GWh of electricity in total) as a result of the co-digestion of sewage sludge with poultry processing waste. A single cubic meter of co-substrates fed to the digesters yielded an average of 25.6 ± 4.3 Nm3 of biogas (between 18.3 and 32.2 Nm3/m3). This enabled covering the energy demand of the plant to a very high degree, ranging from 93.0% to 99.8% (98.2% on average). Importantly, in the presence of the co-substrate, the removal efficiency of organic compounds was enhanced from 64% (mono-digestion) to 69–70%.
Suppression of Supply Current Harmonics of 18-Pulse Diode Rectifier by Series Active Power Filter with LC Coupling
Authors: Sleszynski Wojciech , Cichowski Artur , Mysiak Piotr
Published: November 2020

The reported research aims at improving the quality of three-phase rectifier supply currents. An effective method consists of adding properly formed booster voltages to the fundamental supply voltages using a series active filter. In the proposed solution, the booster voltages are generated by three single-phase systems consisting of inverters, LC filters, and single-phase transformers. The application of LC couplings ensures low emission of disturbances, but may provoke compensator stability problems. The article presents the current control system for a series active filter designed to suppress the dominant harmonics in the supply currents of an 18-pulse rectifier, without interference into fundamental current components. A proportional control is proposed in combination with integral terms implemented in the orthogonal coordinate systems, which synchronically rotate with frequencies equal to those of the harmonic components to be eliminated. The use of complex gains in integral terms allows a simple phase correction of the output signals. A description is given of the method to determine controller parameters based on the mathematical model of the control object. Sample results of experimental tests performed in steady-state and transient conditions are included to illustrate the quality of performance of the series active filter as compared to the results recorded for the rectifier alone, and for the rectifier with additional line reactor. The applied control method of active filter significantly reduces harmonic distortion of the grid current, which is particularly advantageous at nonideal supply voltage and low loads.
A Stacked Denoising Sparse Autoencoder Based Fault Early Warning Method for Feedwater Heater Performance Degradation
Authors: Li Xingshuo , Liu Jinfu , Li Jiajia , Li Xianling , Yan Peigang , Yu Daren
Published: November 2020

Power grid operation faces severe challenges with the increasing integration of intermittent renewable energies. Hence the steam turbine, which mainly undertakes the task of frequency regulation and peak shaving, always operates under off-design conditions to meet the accommodation demand. This would affect the operation economy and exacerbate the ullage of equipment. The feedwater heater (FWH) plays an important role in unit, whose timely fault early warning is significant in improving the operational reliability of unit. Therefore, this paper proposes a stacked denoising sparse autoencoder (SDSAE) based fault early warning method for FWH. Firstly, the concept of a frequent pattern model is proposed as an indicator of FWH performance evaluation. Then, an SDSAE- back-propagation (BP) based method is introduced to achieve self-adaptive feature reduction and depict nonlinear properties of frequent pattern modeling. By experimenting with actual data, the feasibility and validity of the proposed method are verified. Its detection accuracy reaches 99.58% and 100% for normal and fault data, respectively. Finally, competitive experiments prove the necessity of feature reduction and the superiority of SDSAE based feature reduction compared with traditional methods. This paper puts forward a precise and effective method to serve for FWH fault early warning and refines the key issues to inspire later researchers.
Sustainable Business Models: A Bibliometric Performance Analysis
Authors: Marczewska Magdalena , Kostrzewski Mariusz
Published: November 2020

Sustainable business models have become a phenomenon of global interest. Since the beginning of the 21st century, companies have sought to shift from traditional business models towards sustainable ones in order to leverage their sustainable performance and increase their competitive advantage. The aim of this paper is to provide an extensive overview of the academic research on sustainable business models with the focus on inquiry of main trends related to business and economics studies and identification of future research directions. This paper reviews existing literature on sustainable business models in order to map this research stream and identify the most substantial contributors to the advances of research in this field. It contributes to the existing body of knowledge on sustainable business models by: (1) describing the most influential and high-impact researchers/authors, journals, and papers; (2) highlighting main and most important research trends related to sustainable business models in studies on business and economics; and (3) identifying future research agendas in investigating sustainable business models from business and economics perspectives.
Study on the Law of Fracture Evolution under Repeated Mining of Close-Distance Coal Seams
Authors: Cui Feng , Jia Chong , Lai Xingping , Yang Yanbing , Dong Shuai
Published: November 2020

The western region of China is rich in mineral resources. The vigorous development of mineral resources has exacerbated the environmental and safety problems in the region. One of the important links to solve this problem is to control the development laws and distribution characteristics of the overburdened cracks in the mining of this area. In this paper, the Xiashijie coal mine 3-2 coal seam and 4-2 coal seam are examples of repeated mining, and are examined as the background, through theoretical analysis to optimize the size of the coal pillars in the lower section, using the 3DEC numerical simulation experiment method and the rise of the cracks in the short-distance coal seam. Repeated mining monitoring and analysis of the development law are used to ascertain distribution characteristics of overburdened cracks caused by the repeated mining process of the working face. The results show that: (1) By establishing a mechanical model of the overlying strata structure under short-distance coal seam group mining, and carrying out the force analysis of the double section coal pillar under repeated mining, the reasonable size of a lower section coal pillar was determined to be 70 m. (2) As the development height of a fracture progresses with the working face, its expansion rate undergoes four obvious changes: fluctuations within a certain range, the expansion rate reaches the peak after the rock formation is concentrated and broken, the cyclical change gradually decreases, and the expansion rate is zero after complete mining. (3) The fracture zone height of 222 and 224 face under repeated mining in the 4-2 coal seam was 19.56–22.31 times and 22.38–24.54 times larger, respectively, and the post-mining fracture extension of the face with larger width and deeper burial under repeated mining was higher than that of the adjacent face. This study provides scientific guidance for the rational division of coal pillars and the solution of the problem of water conservation mining under repeated mining in the adjacent face of a short-distance coal seam.
Computer Simulation of Passive Cooling of Wooden House Covered by Phase Change Material
Authors: Charvátová Hana , Procházka Aleš , Zálešák Martin
Published: November 2020

The paper is devoted to computer simulations of the distribution and time evolution of the temperature in a wooden house in summer. The goal of simulations was to assess the effect of covering walls inside the house with a PCM (phase change material) on its passive cooling, which prevents the undesired overheating of the house and provides the required thermal comfort for the occupants under warm summer days. Computer simulations were performed by the COMSOL Multiphysics software (COMSOL Inc., Stockholm, Sweden). A model of a house without the PCM coverage was compared with models of houses in which the PCM was located on all walls, except a floor, and on a wall opposite the window. Results of simulations proved that the wood wall thickness and PCMs location influence overheating the wooden house. Under studied conditions, the coverage of a wall opposite the window best eliminated extremes of the air temperature inside the house. The maximum temperature decrease was 3.9 °C (i.e., drop of 31.1%) comparing the house which wall opposite the window was covered by the PCM and the house without the PCM coverage.
Heuristic Optimization of Overloading Due to Electric Vehicles in a Low Voltage Grid
Authors: Haider Sajjad , Schegner Peter
Published: November 2020

It is important to understand the effect of increasing electric vehicles (EV) penetrations on the existing electricity transmission infrastructure and to find ways to mitigate it. While, the easiest solution is to opt for equipment upgrades, the potential for reducing overloading, in terms of voltage drops, and line loading by way of optimization of the locations at which EVs can charge, is significant. To investigate this, a heuristic optimization approach is proposed to optimize EV charging locations within one feeder, while minimizing nodal voltage drops, cable loading and overall cable losses. The optimization approach is compared to typical unoptimized results of a monte-carlo analysis. The results show a reduction in peak line loading in a typical benchmark 0.4 kV by up to 10%. Further results show an increase in voltage available at different nodes by up to 7 V in the worst case and 1.5 V on average. Optimization for a reduction in transmission losses shows insignificant savings for subsequent simulation. These optimization methods may allow for the introduction of spatial pricing across multiple nodes within a low voltage network, to allow for an electricity price for EVs independent of temporal pricing models already in place, to reflect the individual impact of EVs charging at different nodes across the network.