bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPERT OPINION ON THE CLINICAL USE OF ANGIOTENSIN RECEPTOR-NEPRILYSIN INHIBITORS IN THE MANAGEMENT OF HEART FAILURE IN REAL-WORLD INDIAN SETTINGS
Authors: S Manjula , Kumar M Krishna
Published: September 2024

Background: Though there are several studies shown the efcacy of sacubitril/valsartan in patients with HFrEF, there is
a dearth of studies among clinicians. To gather expert opinion on the use of angiotensin receptor-n Objective: eprilysin
inhibitor (ARNI) therapy in managing heart failure (HF) patients in real-world Indian settings. Methodology: The cross-sectional study utilized
an 18-item, multiple-response questionnaire to gather expert opinion from cardiologists in managing HF. The survey encompassed questions
about current prescription practices, clinical observations, preferences, and experiences related to the use of ARNI in routine settings for HF
management. The data were analyzed using descriptive statistics. Results: More than half (66.67%) of the clinicians expressed a preference for
the ARNI (sacubitril/valsartan) drug class for managing HF. Nearly 66% of the respondents noted that the dual action of ARNI on the reninangiotensin-aldosterone system and natriuretic peptides (RAAS & NPs) pathway results in better outcomes with reduced mortality rates.
Approximately 34% of clinicians highlighted cardiac remodeling as a distinct advantage of ARNI over other available drugs, while another 33%
emphasized additional benets such as biomarker improvement, reduced hospitalization, and disease progression. Majority (84.78%) of the
clinicians concurred with the ndings of the PIONEER-HF study, indicating that early initiation of ARNI in acute HF leads to early improvement
in post-discharge outcomes. Additionally, most clinicians (89.13%) reported that sacubitril/valsartan 100 mg (49/51 mg) was commonly used for
HF management. he study revealed a strong preference among clinicians for ARNI in HF management, and Conclusion: T the widespread use of
sacubitril/valsartan 100 mg (49/51 mg). It highlighted the dual action of ARNI on the RAAS and NPs pathway, leading to improved outcomes as
well as the importance of early ARNI initiation in acute HF.
CASE REPORT OF EMPTY SELLA SYNDROME
Authors: Hareshkumar Varde Jagatkumar , Kanodia Nishant , Verma Durga Prasad , Sk Mahamad Sk Nadim , Noor Sabeeha , Rohith B.
Published: September 2024

Introduction: Empty Sella syndrome (ESS) is a symptom complex characterized by headache, giddiness, vomiting,
visual eld defects and endocrine abnormalities along with the radiographic appearance of an enlarged Sella turcica.
Case: We are reporting a case of 42 years old multiparous woman presented with features of hypothyroidism with low mood diagnosed with empty
Sella syndrome based on clinical symptoms and hormonal studies with radiological investigations. pa Discussion – tient presented with classical
hypothyroidism features for long time and repeated hospitalization in past should be evaluate with hormonal studies to rule out causes of
hypopituitarism specially in multiparous woman
COMPARATIVE ANALYSIS OF CLASSICAL AND AGGRESSIVE RETINOPATHY OF PREMATURITY: A ONE-YEAR PROSPECTIVE STUDY AT A TERTIARY OPHTHALMIC CENTRE IN NORTH INDIA
Authors: Mishra Priyanka , Bala Saroj , Singh Karamjit , Kumar Ashwani , Bhatti Anubha , Yadav Jyoti
Published: September 2024

This one-year prospective cross-sectional study aimed to analyse and compare the demographic characteristics, incidence,
and risk factors associated with classical retinopathy of prematurity (ROP) and aggressive ROP (AROP) in neonates.
Conducted at a tertiary ophthalmic centre in North India, the study included 343 neonates with birth weights ≤ 2000 grams and gestational ages ≤ 35
weeks. The neonates diagnosed with ROP were divided into two groups: classical ROP (Group A) and AROP (Group B). Of the 343 neonates
screened, 165 developed ROP, resulting in an overall incidence of 48.10%. Classical ROP accounted for 44.02% (151 cases) and AROP for 4.08% (14
cases). Pre-plus and plus disease incidence among eyes with ROP were 10% and 5.15%, respectively. Zone 2 disease was observed in 98.78% of eyes,
and Zone 1 in 1.21% of eyes. There were 203 eyes with stage I, 100 with stage II, and 25 with stage III disease. Early gestational age (p=0.045) and low
birth weight (p=0.00) were signicantly associated with disease severity. Signicant maternal and neonatal risk factors included gestational diabetes
(p=0.0005), placental bleeding (p=0.0026), respiratory distress syndrome (p=0.0009), and surfactant administration (p=0.00). The duration of oxygen
supplementation was an independent risk factor (p=0.00). Increasing awareness about ROP, regulated oxygen administration, timely screening, and
early treatment of high-risk infants can lead to favourable structural and functional outcomes.
A RARE CASE SERIES OF GUILLAIN BARRE SYNDROME IN ANTENATAL WOMEN
Authors: Namratha Ambarkar , Preethika Preethika
Published: September 2024

Guillain Barre syndrome (GBS) in pregnancy can cause maternal mortality due to respiratory failure. During pregnancy,
its incidence is estimated to be between 1.2 to 1.9 cases per 100,000 pregnancies. It can occur at any trimester, with a
higher risk observed in the third trimester and early postpartum period. There is no risk of preterm birth or fetal malformations . Here we presenting
a case series of pregnant women with the complaints, suspecting GB syndrome and with pregnancy outcome of mother and the baby.
CORRELATION BETWEEN GASTRIC ASPIRATE POLYMORPHS AND NEONATAL SEPSIS.: A CROSS-SECTIONAL STUDY
Authors: Vaidya Sanket , Reddy Hemangi , Aggarwal Nischay
Published: September 2024

Background: Neonatal septicaemia remains a signicant cause of morbidity and mortality in newborn infants. Neonatal
sepsis is difcult for diagnosing clinically because the symptoms and signs are not always readily apparent. Recently,
microscopic appearances of uid from gastric aspirate (GA) have been used as evidence of bacterial sepsis acquired in utero. Therefore, the
present study was conducted to study the correlation between gastric aspirate polymorphs and neonatal sepsis. The Material and Methods:
present study was observational cross-sectional study carried out at Department of Paediatrics of tertiary care centre during July 2023 to June
2024. A total of 102 neonates who had the clinical symptoms and signs of suspected neonatal sepsis admitted in hospital was included in the study
population. Each patient was subjected to a detailed physical examination and history. Blood samples were taken at admission and subjected to
TLC and CRP. Simultaneously, the blood sample for sensitivity and blood culture was taken. Simple, sterilized tubes containing the gastric
aspiration were sent for cytology. The statistical software namely SPSS 22.0 used for the analysis of the data. A total of 102 neonates Results:
were screened for neonatal sepsis among which majority of the patients were males 54 (52.94%). Among them 43 (42.16%) were term and 59
(57.84%) were preterm. The majority of neonates positive for CRP (70.58%) followed by GA polymorphs (65.68%), blood culture (54.91%) and
TLC. (25.49%) GA polymorphs was found to be highly sensitive parameter. (96.43%) Gastric aspirate po Conclusion: lymorphs as a screening
tool for neonatal sepsis with good sensitivity and specicity serves as good tool for neonatal screening
UNVEILING NAIL PATELLA SYNDROME: A MULTIFACETED GENETIC TALE OF CLINICAL CHALLENGES AND MANAGEMENT STRATEGIES TO PREVENT COMPLICATIONS
Authors: Radhakrishnan Arvind , Maria Xavier Asha , Vigneshwaran J
Published: September 2024

Nail Patella Syndrome (NPS), a rare autosomal dominant genetic disorder occurring in approximately 1 in 50,000 live
births, underscores the importance of early identication and intervention in outpatient settings due to its potential
systemic complications, including glaucoma and glomerulonephritis. A 35-year-old female presented to the GM OPD with complaints of
fatigue. On examination, she exhibited several clinical ndings suggestive of NPS: xed exion deformity of the elbow, nail pterygium, and
absent distal interphalangeal (DIP) joint creases in both upper and lower limbs. Fundoscopy revealed cupping in the right eye without visual
defects. Urine routine examination showed no proteinuria. Radiological investigations further supported the suspicion of NPS: X-ray of the
elbows revealed bilateral radial subluxation, while X-ray of the knees showed hypoplastic and inferiorly displaced patellae bilaterally.
Additional imaging included X-ray of the pelvis, revealing bilateral iliac horns, and X-ray of the thorax, indicating a hypoplastic right scapula
and thoracic vertebral scoliosis. Tonometry revealed elevated intraocular pressure, with readings of 27mmHg in the right eye and 25mmHg in the
left eye. These ndings collectively suggest a diagnosis of NPS. The clinical spectrum of NPS includes nail pterygium, triangular lunula, nail
dysplasia, loss of DIP crease, xed exion deformity in the elbow, hypoplastic and inferiorly dislocated patella, kyphosis, scoliosis, hypoplastic
scapula, glaucoma, and glomerulonephritis. In this patient, the diagnostic tetrad for NPS was observed: ngernail dysplasia, absent or
hypoplastic patella, posterior iliac horns, and subluxation of radial heads on X-ray, associated with the LMX1B gene on chromosome 9q33.3.
Systemic complications arise from abnormal collagen IV regulation, leading to glaucoma and glomerulonephritis. Management included
antiglaucoma medication and yearly urine examination and tonometry. Early detection of genetic disorders like NPS allows for comprehensive
counseling and proactive management to mitigate long-term consequences such as vision loss and chronic kidney disease.
Review Artikel: Daun Jati Belanda dengan Potensi Penurunan Kadar Lipid dalam Darah
Authors: Wulandari Prihastini Setyo
Published: September 2024

Penelitian ini mengevaluasi efektivitas daun jati belanda (Guazuma ulmifolia Lamk.) dalam menurunkan kadar lipid darah, termasuk kolesterol dan trigliserida. Berdasarkan telaah data dari berbagai sumber, penggunaan daun jati belanda pada dosis antara 25 mg/kgBB hingga 800 mg/kgBB pada tikus dan 1000 mg/kgBB pada ayam broiler menunjukkan penurunan kadar lipid yang signifikan. Senyawa aktif dalam daun jati belanda, seperti beta-sitosterol, alkaloid, flavonoid, saponin, tanin, antosianin, steroid, dan triterpenoid, berkontribusi pada penurunan kadar lipid dengan mekanisme yang meliputi penghambatan enzim lipase pankreas dan pengurangan penyerapan lemak di usus. Penelitian menunjukkan bahwa ekstrak etanol daun jati belanda efektif dalam menurunkan kadar LDL, meskipun tidak berpengaruh signifikan terhadap peningkatan HDL. Penambahan tepung daun jati belanda ke dalam pakan broiler juga terbukti menurunkan kadar trigliserida dan lemak abdominal. Meskipun data dari penelitian hewan mendukung efektivitas daun jati belanda, diperlukan penelitian lebih lanjut pada manusia untuk memastikan efektivitas dan keamanan klinisnya, serta untuk menentukan dosis optimal dan potensi efek samping atau interaksi dengan obat lain
Effect of Manganese Chloride and Zinc Chloride on Physiological Characteristics of Myriophyllum verticillatum and Schoenoplectus litoralis
Authors: AL-Janabi Qassim Ammar Ahmood , Tarrad Mohammed Raheem , Albieg Hasan Ahmed Ali
Published: September 2024

The purpose of the study was to evaluate the effects of varying concentrations of manganese and zinc chloride (10, 20, and 30 mg/L) on the physiological traits of Schoenoplectus litoralis and Myriophyllum verticillatum, as well as to measure the levels of total chlorophyll and protein content. The study was conducted for one month. The research results demonstrated that the water plants used for the investigation had higher component concentrations at the conclusion of the investigation when compared to the control sample. Additionally, the water plants exposed to the effects of heavy metals had lower levels of protein and chlorophyll.
The Effect of Pre-Cooling on the Pain of Local Anesthesia Injections in Children
Authors: Almaeeni Mais Mahdi
Published: September 2024

Background: Fear from dental injection among children is considered the main obstacle to the dentist while delivering local anesthesia. So, this study used a pre-cooling technique at injection site and compared it to conventional methods. The study aimed to assess external cooling efficiency on the injections’ pain of at the site of local anesthesia in children had dental treatment. Materials and Methods: The study subjects were 60 children with dental treatment in mandibular region. The study group were anesthetized after cold application of the injection site for 2 minutes, while the control group were administered local mandibular anesthesia after topical anesthesia application. Independent student t-test was used for means comparison. Results: The pain scores were lower in the study group with no significant difference between groups (P <0.5). Conclusions: There was no significant difference between the study and control groups on the injection pain, but it was more tolerable by children and easier to apply than conventional topical anesthesia.
Pharmacological Effect of Eugenol on Freund's Adjuvants -Induced Arthritis in Experimental Rats
Authors: Hashim Mays U.
Published: September 2024

The objective of this experimental investigation was to examine the efficacy of eugenol. Against arthritis induced by complete Freund's Adjuvants (CFA) injected subcutaneously into the hind paw of the experimental rat model. Macroscopic clinical indication of Polyarthritis shows first erythema and edema in the hind paws of rat. Groups of this experiment were divided as follows, first groups was positive control while second and third groups received daily treatment with eugenol and dexamethasone orally via intragastric tube at doses (10 mg/ and 1mg/ Kg) respectively for 7 days. The initiation of treatment occurred on the day 7 from the day of induction of arthritis and continued up to day 14, at which point the rats were each sacrificed. The left and right paw volume variations were all measured on different days up to 14 days and after14 days, Tumor necrosis factor-α, Interleukin -10, and histopathological change were measured. Significant reduction (P≤0.05) in the development of edema in the hind paw was observed in the group treated with eugenol compared to dexamethasone and positive control groups. The histological examination revealed that the groups treated with eugenol had a normal articular cartilage and joint cavity, in contrast to the other group. Furthermore, eugenol maintained normal levels of the cytokine markers as inflammatory indicators, with significant difference from control groups. consequently, the results of the current investigation indicate that eugenol can be used as anti-inflammatory treatments and can be used as a beneficial adjuvant in the treatment of human arthritis.
Laryngeal Carcinoma: Topographical Distribution
Authors: Rahman Dr. Md. Atikur , Haque Dr. Md. Mahbobul , Mridha Dr. Md. Mohsin , Hasan Dr. Md. Mehedi , Zamil Dr. Mohammad Safayet , Jamil Dr. Abu Naser Md , Rumi Prof. Dr. SK Nurul Fattah
Published: September 2024

Background: Head and neck cancer is the eighth most common cancer (1-2%) as estimated from worldwide data. Laryngeal malignancy is the second most common malignancy in head neck region worldwide. There are variety of malignant tumour arising in larynx. Carcinoma of the larynx interferes with most vital functions in the sufferers like voice, respiration and swallowing by virtue of its anatomical location, local infiltration and direct extension. Objectives: The aim of the study was to evaluate the laryngeal carcinoma: topographical distribution. Methods: This cross-sectional observational study was carried out in the Department of Otolaryngology & Head-Neck Surgery, Dhaka Medical College Hospital during January 2019 to July 2020. Purposive consecutive sampling method was used to collect data. After taking detailed history, clinical examination including indirect laryngoscopy, fiber optic layngoscopy CT scan of neck & direct laryngoscopic evaluation under general aneasthesia was done. Statistical analyses of the results were be obtained by using window-based Microsoft Excel and Statistical Packages for Social Sciences (SPSS-24). Results: Total 93 patients of different age, sex, socioeconomic status was taken. Hoarseness of voice (87.1%), dysphagia (58.1%), difficulties in breathing (57%) and neck lump (50.5%) were the common presenting complaints. 87.1% patients were smoker. Most of patients were attended with stage-III disease. Supraglottis (63.4%) was the most common site of laryngeal cancer followed by glottic (34.4%) and subglottic (2.2%). Aryepiglottic fold (23.73%) and epiglottis (20.74%) are commonly involved in supraglottic carcinoma. Single vocal cord commonly involved in glottic carcinoma. Most supraglottic carcinoma involved more than one sub site (52.34%). Supraglottic carcinoma is the most common site of laryngeal carcinoma. Combined sub site is more involved in supraglottic carcinoma. Conclusion: The topographical distribution of laryngeal carcinoma play
The Influence of Implementation of Risk-Based Audit and Utilization of Information Technology on Tax Audit Quality
Authors: Maulana Fajar , Devano Sony , Harahap Devianti Yunita
Published: September 2024

The low quality of tax audits is one of the sources of tax disputes. Therefore, tax audit actions should be carried out optimally, effectively, efficiently, and with high quality. The purpose of this research is to determine the influence of the implementation of risk-based audit and the utilization of information technology on the quality of tax audits. The research method used in this study is a quantitative approach with a descriptive method through a survey conducted by distributing questionnaires to the respondents, the Heads of Tax Offices (KPP), in Jakarta and West Java regions, as well as the Middle Taxpayers Offices (KPP Madya) throughout Indonesia. The research obtained a sample of 44 respondents. The data analysis technique used is Multiple Linear Regression analysis with the assistance of SPSS Version 23 software. The results of this study indicate that the implementation of risk-based audit has a positive effect on the quality of tax audits. The utilization of information technology also has a positive effect on the quality of tax audits. Simultaneously, the implementation of risk-based audit and the utilization of information technology affect the quality of tax audits.
Maximizing Retail Accounting Performance: A Synergy of Technology Assets and User Capability
Authors: Michael Michael , Widjaja William
Published: September 2024

The widespread adoption of Accounting Information Systems (AIS) in Indonesian retail stores underscores its significance in enhancing operational efficiency and effectiveness, as consumer surveys indicate increased shopping ease and efficiency. This study, conducted with a sample of 150 employees from mini-market retail stores in Jakarta, employs a quantitative survey approach with SEM-PLS to examine the impact of technology assets and user capabilities on AIS performance. Results reveal significant effects of technology assets on AIS performance. Proficient user capabilities further enhance AIS performance, moderating the effect of technology assets. Theoretical implications highlight integrating technological knowledge and user skills in AIS design. In contrast, practical implications suggest investing in advanced technology and employee training to optimize AIS benefits, ultimately improving retail operations' efficiency, accuracy, and customer satisfaction. This research offers valuable insights for stakeholders to make informed decisions and address the challenges of intense competition in the retail industry.
Impact of Fluctuating BI 7-Day Reverse Repo Rate Movement on Jakarta Composite Index Value: Date-Regular Frequency Data
Authors: Yandes Jufri , Destiana Destiana
Published: September 2024

A study was conducted to explore the impact of fluctuating BI 7-Day Reverse Repo Rate (BI7DRR) movements on the value of Jakarta Composite Index (JCI) in the Indonesian capital market using statistical techniques, focusing on understanding existing knowledge gaps. Through experiments using Date-Regular Frequency data type in linear regression analysis for the period of January 2023 (2023M01) to December 2023 (2023M12). The data has passed the normality, heteroscedasticity, and autocorrelation tests, this study showed that there's a pretty big impact of BI7DRR on JCI, especially when it comes to the fluctuating movement. The results of the analysis show that the volatile movement of BI7DRR has a measurable impact on the value of JCI, reinforced and supported by the results of previous studies whose results can strengthen the findings with a positive constant regression coefficient and supportive hypothesis test results. The results obtained are expected to provide valuable insights for investors, market analysts, and especially policy makers on how the fluctuating movement of BI7DRR can affect the dynamics of the stock market in Indonesia, especially the value of JCI in order to maintain a sustainable economy.
The Influence of Profitability and Leverage on Tax Avoidance with Transfer Pricing as a Moderating Variable (Mining Sector Companies Listed on IDX 2019-2023)
Authors: Puspitasari Dana , Munari Munari
Published: September 2024

The study aims to examine and analyze the influence of profitability and leverage on tax avoidance with transfer pricing as a moderating variable. The research uses a quantitative approach. The population in this study includes all mining sector companies listed on the Indonesia Stock Exchange (IDX) for the years 2019-2023. The sample was selected using purposive sampling method, and based on predetermined criteria, a sample of 20 companies was obtained. The data used is secondary data obtained from the financial statements of the sampled companies. Data was analyzed using the Partial Least Square (PLS) technique. The results of this study indicate that profitability has a significant positive effect on tax avoidance, leverage has a negative and insignificant effect on tax avoidance, transfer pricing is unable to moderate the effect of profitability on tax avoidance, whereas transfer pricing can strengthen the negative effect of leverage on tax avoidance.
The Impact of Financial Performance and Audit Opinion on the Stock Price of Technology Companies
Authors: Wibowo Andrea Safina , Andayani Sari
Published: September 2024

The technology company's commitment to growth and sustainability has placed it in a favorable position for potential development on the stock exchange. This research examined how return on equity, net profit margin, debt-equity ratio, price-earnings ratio, and audit opinion influence stock prices. The study used quantitative methods and focused on companies in the technology sector listed on the Indonesian Stock Exchange (IDX) from 2020 to 2023. The analysis involved double linear regression using SPSS version 25 software. Using purposive sampling, the study selected 18 technology sector companies based on specific criteria, resulting in 72 samples for analysis. The study revealed that return on equity (ROE), price-earnings ratio (PER), and audit opinions have a significant impact on stock prices. In contrast, net profit margin (NPM) and debt-equity ratio (DER) does not impact the stock prices.
ANÁLISE DO PERFIL EPIDEMIOLÓGICO DOS CASOS NOTIFICADOS DE HANSENÍASE NO BRASIL NO PERÍODO DE 2012 A 2022
Authors: Campos Israel , Monique Melo Ferreira Gabrielly , Estevaz Barbalho Macêdo Iago , Alves da Cunha Lanna Karem
Published: September 2024

INTRODUÇÃO: A hanseníase é uma doença infectocontagiosa, de evolução crônica,causada pela bactéria Mycobacterium leprae (também conhecida como bacilo de Hansen),que acomete os nervos e a pele (1). De acordo com o Ministério da Saúde, o Brasil ocupa asegunda posição mundial entre países que registram casos novos de hanseníase.OBJETIVO: Este artigo tem como objetivo analisar o perfil epidemiológico dos casosnotificados de hanseníase no Brasil entre 2012 e 2022. METODOLOGIA: A pesquisaapresenta-se como um estudo ecológico, quantitativo, utilizando dados do Sistema deInformação de Agravos de Notificação (SINAN), disponibilizados pelo Departamento deInformática do Sistema Único de Saúde (DATASUS/TABNET), referente aos casosnotificados de hanseníase no Brasil entre os anos de 2012 a 2022. RESULTADOS: Entre2012 e 2022, o Brasil registrou 369.254 casos de hanseníase. A maior prevalência foiobservada na região Nordeste, com 157.601 casos (42,68%), seguida pela região Centro-Oeste com 74.930 casos (20,29%). As regiões Norte, Sudeste e Sul registraram,respectivamente, 70.603 (19,12%), 53.562 (14,51%) e 12.558 casos (3,40%). O ano de2012 teve o maior número de notificações, com 40.896 casos (11,08%), enquanto 2021apresentou o menor, com 24.858 casos (6,73%). DISCUSSÃO: O ano de 2012 obtevemaior ascensão do número de casos de hanseníase, no entanto, houve uma reduçãosignificativa a partir de 2020, o que pressupõe a subnotificação dos registros dos casos emdecorrência de pandemia do vírus da Sars-cov-2. CONSIDERAÇÕES FINAIS: Conclui-seque a infecção pela bactéria Mycobacterium leprae no Brasil é um problema de saúdepública. Ademais, é imprescindível realizar mais pesquisas acerca da doença para que apartir dessa análise de dados como realizado nesse projeto, os responsáveis por assegurara saúde do corpo social possam montar estratégias para o combate da patologia.
Epidemiologia das hospitalizações por Insuficiência Cardíaca: Retrato brasileiro entre 2020 e 2023
Authors: Brito Lara Romêo Gustavo , Vasconcelos Rodrigues de Oliveira Tonello Laura , Coelho Oswaldo Ana Aline , Schiffl Farina Vinícius , Paixão Pereira Getulio , Barbosa de Souza Albodelli Mariana , Aparecido Souza Ryan Victor , Montes Corrêa Ríllary , Sabino Kauana , Rodrigues Flamengo Pedro Henrique
Published: September 2024

A insuficiência cardíaca (IC) é uma condição clínica grave que impacta significativamente os sistemas de saúde, especialmente devido à sua alta morbidade e mortalidade. Com o aumento da prevalência global, impulsionado pelo envelhecimento da população e prevalência de condições crônicas como hipertensão e diabetes, o Brasil observou um crescimento nas hospitalizações por IC entre 2020 e 2023. Adotou-se uma análise epidemiológica quantitativa e retrospectiva baseada em dados do Sistema de Informações Hospitalares do SUS (SIH/SUS). Foram coletados e analisados dados sobre internações por IC, incluindo variáveis demográficas e clínicas dos pacientes, utilizando o software Microsoft Excel 2019 para análise estatística e construção de tabelas descritivas. Os resultados indicaram um aumento nas taxas de incidência e mortalidade de IC no período, com variações significativas entre as regiões brasileiras. A maior concentração de casos e letalidade foi observada no Sudeste. Além disso, a prevalência foi maior em indivíduos mais velhos e do sexo masculino. As comorbidades frequentes como doença renal crônica e diabetes foram prevalentes entre os pacientes hospitalizados. A pandemia de COVID-19 exacerbou as dificuldades no manejo da IC, com uma sobrecarga nos sistemas de saúde e aumento das taxas de letalidade, especialmente durante o ano de 2021. Foi destacada a necessidade de políticas de saúde pública mais eficazes e intervenções precoce, especialmente nas regiões com alta mortalidade e letalidade, para melhorar o acesso e qualidade dos cuidados de saúde. Este estudo revelou desigualdades significativas no acesso e na qualidade do tratamento da IC no Brasil, com destaque para a necessidade de intervenções e políticas direcionadas a melhorar a equidade no tratamento da condição. A implementação de programas de prevenção e campanhas de conscientização focadas nas comunidades mais vulneráveis é crucial para reduzir a incidência e melhorar os desfechos clínicos de forma mais equitativa.
Descrição dos indicadores de morbidade por neoplasia maligna do cólon na região Nordeste em 2023
Authors: Sampaio Machado Dias Carvalho Maria Eduarda , Duarte Araújo Beatriz , Góes Medeiros Bruna , Barros Canto Ana Clara , Andrade Coêlho Mateus , Hermínio de Almeida Filho Kildare , de Moura Lima Anna Clara , Mattos de Moraes Marco Antônio , Carvalho de Almeida Camilla , de Castro Nagata Maiana Larissa
Published: September 2024

A neoplasia maligna do cólon é uma das formas mais prevalentes e letais de câncer no mundo, caracterizando-se pelo crescimento anormal de células que podem invadir e se espalhar para outras partes do corpo. Este estudo foca na região Nordeste em 2023, buscando explorar as particularidades regionais que influenciam a incidência e o manejo da doença, incluindo fatores de risco como idade avançada, histórico familiar, dietas inadequadas, sedentarismo, obesidade e o impacto de comorbidades como diabetes e doenças cardíacas. O estudo retrospectivo analisou dados de internações hospitalares especificamente atribuídas à neoplasia maligna do cólon, selecionando estudos publicados em português ou inglês e disponíveis nas bases de dados mencionadas. As variáveis foram analisadas para proporcionar uma visão detalhada da distribuição e impacto das internações. Os dados mostram alta prevalência de câncer de cólon entre indivíduos de 60 a 69 anos, com predominância de internações entre mulheres e indivíduos de cor parda, refletindo possíveis desigualdades no acesso aos cuidados de saúde e influência de determinantes sociais. A análise também destacou a importância de fatores de risco como hábitos alimentares e comorbidades como diabetes e doenças cardíacas no manejo da doença. Ressalta-se a complexidade da fisiopatologia do câncer de cólon, influenciada por alterações genéticas e epigenéticas, e a importância de um diagnóstico precoce e tratamento adequado. As disparidades regionais e socioeconômicas exigem uma abordagem diferenciada e focada nas particularidades da região Nordeste. Observa-se a necessidade de políticas de saúde que melhorem o acesso a diagnóstico e tratamento, considerando as particularidades demográficas e socioeconômicas. A implementação de estratégias de saúde pública eficazes pode melhorar significativamente os desfechos para pacientes com neoplasia maligna do cólon na região Nordeste.
Analgesia peridural contínua: análise da eficácia, efeitos adversos e fatores de risco
Authors: Pedro Vergílio Lugão de Azevedo  , Samuel Ribeiro Martins  , Rafael Pinheiro Cohen  , Juliana Louvise Carvalho  , Luís Eduardo Arcoverde Nogueira Brayner  , Laila Fernanda Santana Barra  , Mariana Coelho Carlette  , Renato de Souza Susanna Machado  , Afonso Luis de Filippi Leal  , Ana Paula de Souza Guedes  , Lorena da Silva Pereira  , Anderson Souza Correia  , Julyana Krüger Pilon  , Thayná Vattimo Carbalheda da Silva  , Lisia Raquel Fernandes Paz  , Andrezza Fagundes Soares  , Rayza Pereira Barbosa  , Beatryz Rodrigues Alves Batista  , João Rafael Queiroz Soares  , Gustavo Sousa Andrade  , Flávia Nayra Araújo Rodrigues  , Mayra Luana Fernandes Sousa  , Janiele Domiciano Dantas de Sousa  , Eloisa Meneses de Morais Fontana  , Nayara Fernanda Nazareno Rodrigues Tasca  , Eloá Perciano Madeira da Silva  , Nathan dos Santos Rodrigues  , Guilherme Dias Miranda Salgado Ribeiro
Published: September 2024

A analgesia peridural contínua é eficaz no controle da dor, oferecendo alívio prolongado e melhorando a qualidade de vida dos pacientes. No entanto, é crucial monitorar os efeitos adversos, como hipotensão e retenção urinária, bem como os fatores de risco associados, como complicações relacionadas ao cateter e técnica inadequada. A gestão cuidadosa desses aspectos é essencial para equilibrar os benefícios da analgesia peridural contínua com a segurança e o conforto dos pacientes. O objetivo desta revisão sistemática consiste em analisar a eficácia da analgesia peridural contínua, identificar seus efeitos adversos e avaliar os fatores de risco associados a essa técnica para aprimorar a prática clínica e a gestão da dor. Scopus e PubMed foram utilizados como bases de dados científicos para a seleção dos artigos, com o uso dos unitermos em língua inglesa: “Continuous epidural analgesia, Efficacy, Adverse effects, Risk factors”. Conclui-se que a analgesia peridural contínua é amplamente reconhecida por sua eficácia no controle da dor, sendo especialmente valiosa em contextos de dor crônica e aguda. Os estudos revelam que essa técnica proporciona alívio prolongado e melhora a qualidade de vida dos pacientes. No entanto, a sua aplicação não está isenta de riscos. Efeitos adversos como hipotensão e retenção urinária, além de complicações relacionadas ao cateter e técnica inadequada, são preocupações relevantes. A gestão eficaz desses riscos é crucial para garantir os benefícios da analgesia peridural contínua. Embora a analgesia peridural contínua seja uma ferramenta potente no manejo da dor, é fundamental equilibrar seus benefícios com uma vigilância rigorosa sobre os possíveis efeitos adversos e fatores de risco para otimizar a experiência do paciente.
Urbanization and Economic Sustainability: Balancing Growth and Environmental Responsibility
Authors: Joshi Karthik
Published: September 2024

The connection between increasing urbanisation and economic expansion has been a source of much concern. If the change of human civilization that has taken place since the beginning of the Industrial Revolution were to be summed up in no more than three words, there are few possibilities that are more appropriate than urbanisation, industrialization, and globalisation. These three aspects are intertwined and interdependent on one another. Industrialization results in the direct output of economic growth, which, in turn, provides additional impetus to a vigorous process of urbanisation in both developed countries and newly industrialised ones. This is accomplished primarily through the specialisation of labour and the unprecedented development of non-agricultural sectors. The historical evidence and statistical data unequivocally demonstrate that the vast majority of industrialised nations have both a greater degree of urbanisation and a higher level of GDP per capita than less developed nations do.
Azərbaycanda fortepiano ifaçılığının yaranma tarixi
Authors:   AEM ( Azerbaijan Science Center ), Babayeva Zemfira
Published: September 2024

Xülasə Müəllif məqalədə Naxçıvan Muxtar Respublikasında bəstəkarlığın yaranma tarixindən, eyni za­man­da onun inkişafından bəhs edir. İlk musiqi məktəbinin açılmasında və bəstəkarlığın inkişa­fında bu məktəbin rolundan söhbət açır. Məqalədə eyni zamanda aşıq yaradıcılığından danışılır. Bundan başqa, Ərtoğrul Cavidin yadigar qalmış kamançası haqqında məlumat verilir, burada yaşamış musiqiçilərdən söhbət açılır.
Ethical Implications of AI in Data Collection: Balancing Innovation with Privacy
Authors:   AEM ( Azerbaijan Science Center ), Mirishli Shahmar
Published: September 2024

Abstract This article examines the ethical and legal implications of artificial intelligence (AI) driven data collection, focusing on developments from 2023 to 2024. It analyzes recent advancements in AI technologies and their impact on data collection practices across various sectors. The study compares regulatory approaches in the European Union, the United States, and China, highlighting the challenges in creating a globally harmonized framework for AI governance. Key ethical issues, including informed consent, algorithmic bias, and privacy protection, are critically assessed in the context of increasingly sophisticated AI systems. The research explores case studies in healthcare, finance, and smart cities to illustrate the practical challenges of AI implementation. It evaluates the effectiveness of current legal frameworks and proposes solutions encompassing legal and policy recommendations, technical safeguards, and ethical frameworks. The article emphasizes the need for adaptive governance and international cooperation to address the global nature of AI development while balancing innovation with the protection of individual rights and societal values.
Qərbi Azərbaycana qayıdış
Authors:   AEM ( Azerbaijan Science Center ), Qədimova Nərminə
Published: September 2024

Xülasə Qərbi Azərbaycan torpaqlarında hər daş, hər qaya sanki: “Mən qədim oğuz eli, türk yurduyam”- deyir. Yerin altından da, yerin üstündən də türk izləri çıxır. Yerin üstündəkiləri saxtalaşdıran ermənilər yerin altından da bu izləri yox etməyə çalışırlar. Tarixin qənimi ermənilər İrəvan şəhərinin köhnə simasını tam dağıdıb, torpaq altında gizlədiblər. Azərbaycan şəhəri İrəvanın Qantar bazarını söküb, yerində uşaq parkı saldılar. İndi qazıntı zamanı buradan tapılan İrəvan xanına aid şəxsi əşyalar, eləcə də Azərbaycan irsinə aid maddi və mənəvi sübutlar erməni yalanı müəlliflərini çətinə salıb deyə, min cür yalanla nağıllar uydurub, gerçəyi yenidən torpaq altına gömürlər. Ermənilər məhz maliyyəni bəhanə edib tarixi həqiqəti - İrəvan şəhərində Azərbaycan tarixini və mədəniyyətini torpaq altında məhv edirlər. Bu vandallar azərbaycanlıların tarixi-etnik torpaqlarındakı izlərini silməklə yanaşı, onlara məxsus toponimlərə qarşı da soyqırım həyata keçirmişlər. Əvvəllər azərbaycanlıların yaşadıqları 703 yaşayış məntəqəsinin adlarını dəyişdirərək erməniləşdirmişlər. Özlərini dünyaya “qədim xalq”, “mədəni xalq”, kimi təqdim edən ermənilər, həqiqətdə azərbaycanlıların mədəni irsinə qarşı əsl barbarlıq və vandallıq “nümunəsi” göstərirlər və xristian ölkələrinin onları dəstəkləmələri üçün “ilk xristianlığı qəbul edən millət” kimi özlərini təqdim edirlər. Qəribə burasındadır ki, dəyişdirdikləri yer adları yenə də türk sözlərindən ibarətdir.
Trichoderma cinsinə aid göbələk növlərinin antoqonist xüsusiyyətlərinin qiymətləndirilməsi
Authors:   AEM ( Azerbaijan Science Center ), Balaxanova Qumru
Published: September 2024

Xülasə Aparılan tədqiqatlardan aydın olmuşdur ki, Trichoderma cinsinə aid göbələklərin bioloji aktivliyi torpaq tipindən, hidrotermiki rejimdən və həmin biotopa xas olan mikobiotanın tərkibindən asılıdır və konkret şəraitdə həmin yerdən ayrılan ştammın istifadəsi daha effektli olur. Bunu nəzərə alaraq tədqiqatların gedişində Trichoderma cinsinə aid göbələk növlərinin antoqonist xüsusiyyətlərinin qiymətləndirilməsi məqsədəuyğun hesab edilmişdir. Tədqiqatların sonrakı mərhələsində Trichoderma cinsinə aid olan göbələklərin boy maddəsi sintez edib etməməsi ilə bağlı olmuşdur. Tədqiqatlar nəticəsində sübut olunmuşdur ki, bu göbələklər təbii parçalanma və bioremediasiya agentidir. Son işlərin nəticəsində Trichodermanın pestisidləri və herbisidləri təhlükəsizləşdirən qabiliyyəti aşkar edilmişdir. Bu xüsusi qabiliyyət kənd təsərrüfatı sənayesinə çirklənmə ilə bağlı məsələlərin öhdəsindən gəlmək üçün üstünlük verir. Bütün bunlar göstərir ki, Trichoderma bitki böyüməsini stimullaşdıran, bitki xəstəliklərinin bioloji nəzarət, təbii parçalanma agentidir. Tədqiqatlar nəticəsində müəyyən edilmişdir ki, Trichoderma cinsinə aid olan göbələklərin yüksək antoqonistlik aktivliyə malik olan növləri eyni zamanda antibiotik aktivliyə malik birləşmələrdə sintez edə bilir ki, onlardan da T.asperellum və T.harzianum kimi növünə aid ştamların sintez etdikləri güclü antimikrob aktivliyə malikdir.
Hormonal assessment and body composition in young males with metabolic syndrome
Authors: Cherska Maria S. , Maidaniuk Olena V. , Vdovenko Nataliia V. , Kukharchuk Khrystyna M.
Published: September 2024

Aim: To determine the relationship between body composition and hormonal levels in young men with metabolic syndrome.
Materials and Methods: 123 males with a mean age of 24.1 ± 4.3 years (33 with metabolic syndrome (MS group) and 90 healthy physically active men (control group) were recruited at the study of body composition and hormone status. The total testosterone, cortisol, and insulin in blood serum by ELISA, the body weight (kg), lean body mass (kg) and fat mass (kg, %) by bioimpedance analysis method were investigated.
Results: It was establish the significand difference the mean value of body composition (body weight, lean body weight, fat body mass (kg, %), testosterone, cortisol insulin, and glucose concentration between MS group and control group.
Conclusions: A present study established the significant correlation of testosterone, insulin, and glucose concentration with fat body mass in all participants (MS and control groups). The negativee effect of overweight (BMI > 25; FBM > 18 %) and obesity (BMI > 30; FBM > 25 %) for testosterone concentration was determined due to an increase of FBM > 20 % and insulin increasing > 9,0 μlU/l.
THE ROLE OF BAITUL MAAL WA TAMWIL TUNAS HARAPAN SYANTARA IN THE MANAGEMENT OF CLEAN WATER FACILITIES IN PESANGGRAHAN VILLAGE, EAST LOMBOK
Authors: Sarni Sarni , Rachmad Dedy , Nurrachmi Rininta
Published: September 2024

This research departs from the problem of managing clean water sources in Pesanggrahan Village, East Lombok which was carried out by Baitul Maal wa Tamwil Tunas Harapan Syantara. In conducting research, the study used qualitative research based on interviews, documentation and questionnaires as primary data in this research. In the next stage, the study analyzes the data using management theory and SWOT to look at planning, organizing, implementing, controlling models and the problems faced. After going through a long academic research process, the result indicates that the value of strengths-weakness (2.53-0.58): 2 = 0.98, while opportunities (1.50) – Threats (1.14): 2 = 0.18. The finding also indicates that the SWOT analysis quadrant graphic, the position of clean water source management is in quadrant I, which means it is good for the continuation of clean water management in Pesanggrahan Village. The next strategy that must be carried out is promotion, using advertising, sales promotion, personal selling, direct marketing and public relations.
Exploring Factors Influencing Information Communication Technology in Vocational College Students
Authors: Cui Suxia , Wang Hsuan-Po
Published: September 2024

Information Communication Technology (ICT) has expanded developmental opportunities for contemporary college students and has enhanced their access to diverse learning resources. This study investigates the influence of Perceived Teachers' Informatization Teaching Leadership on Information Communication Technology from the students' perspective, examining the mediating roles of Computer Self-Efficacy (CSE) and Perceived Social Support (PSS). Utilizing a quantitative research approach, the study surveyed vocational college students in China who had experience in skills competitions, with data analysis performed using SPSS software. The results reveal that both Computer Self-Efficacy and Perceived Social Support effectively mediate the impact of Perceived Teachers' Informatization Teaching Leadership from the students' perspective on Information Communication Technology utilization, with significant variations in the strength of their mediation effects. These findings provide new insights into strategies for enhancing Information Communication Technology capabilities among vocational college students in China, thereby advancing their information literacy and potentially informing educational policies and stakeholder decisions.
 
Received: 14 July 2024 / Accepted: 28 August 2024 / Published: 05 September 2024
Teacher Perspectives on Life and Earth Sciences Textbook Evaluation in Moroccan Middle and High Schools
Authors: Saayoun Salaheddine , El Fathi Tarik , Ghizlane Chemsi , Abidi Omar , Lamri Driss , Al Ibrahmi El Mehdi
Published: September 2024

This study provides insights into Moroccan Life and Earth Science teachers' perspectives on the evaluation of textbooks in middle and high schools. The study aims to explore teachers' views on the evaluation of Life and Earth Science textbooks based on content, skills, culture, and textbook functions. Data were collected from 223 Life and Earth Science teachers using a survey instrument with 37 Likert-scale items. The findings indicate that while teachers generally held positive views on the evaluation of textbooks with content and skills-based curricula, there is room for improvement in the cultural aspect. Furthermore, the results highlighted the significant influence of the language of instruction on teachers' perspectives on textbook functions and skills, emphasizing the importance of considering the specific needs and contexts of different school levels. To improve the quality and effectiveness of Life and Earth Science education, the study emphasizes the importance of considering the evaluation of textbooks, as well as school level and language of instruction, in their development and utilization. Overall, this research provides valuable insights into the evaluation of Life and Earth Science textbooks in Moroccan middle and high schools. These findings can help publishers, curriculum developers, and teachers improve the effectiveness and relevance of Life and Earth Science education for Moroccan learners.
 
Received: 16 June 2024 / Accepted: 27 August 2024 / Published: 05 September 2024
Self-Directed Learning Readiness Among Undergraduate Students
Authors: Thanh Thuy Dang Thi , Hung Le Thai , Lien Vu Phuong
Published: September 2024

This study assessed undergraduate students' self-directed learning readiness (SDLR) levels with a case study in Vietnam. The study employed a quantitative method, using an SDLR survey questionnaire. The questionnaires were administered to 1222 undergraduate students at six higher education institutions. The data was analyzed using SPSS 26.0 with descriptive statistics, a T-test, and ANOVA to determine the SDLR level and the difference in gender, primary, and academic year. The research results showed that students reported an SDLR score of 157.15. The findings also revealed that there was no difference by gender and training major in terms of SDLR level. It showed that different years of education possessed different degrees of SDLR (attitude to learning, control in knowledge, confidence and independence in learning, and self-concept in learning). The research would provide suggestions for students, educators, and curriculum designers in Vietnam's curriculum development, teaching, and learning.
 
Received: 12 July 2024 / Accepted: 30 August 2024 / Published: 05 September 2024
The Integration of Environmental Costs into Financial Statements: A Literature Review
Authors: Fernández Salazar Jessica Karina , León Pedro Manuel Silva , Reyes Reyes Carla Angelica , Chuquitucto Cotrina Lisseth Katherine , Arbulú Ballesteros Marco Agustín , Ángeles Guzmán Valle María De los , Arévalo Altamirano Jheimmy Grace , Zevallos Aquino Rocío Liliana
Published: September 2024

The growing concern for sustainability and environmental responsibility has driven companies to integrate environmental costs into their financial statements. However, this process faces challenges and limitations. This systematic review aims to synthesize existing research on the integration of environmental costs into financial statements, identifying the main approaches, methodologies, challenges, and opportunities involved. An exhaustive search was conducted in relevant databases, applying predefined inclusion and exclusion criteria. The selected studies were analyzed using narrative and bibliometric techniques. The results reveal a growing amount of academic attention to this topic, with notable approaches such as environmental management accounting and sustainability accounting. The key challenges identified include difficulty in measuring and quantifying environmental costs, lack of clear regulations, and resistance to organizational change. On the other hand, opportunities include improved decision-making, resource use efficiency, and strengthened corporate reputation. The conclusion emphasizes the need to develop standardized methodologies, establish clear regulatory frameworks, and promote awareness and training in environmental accounting to advance the effective integration of environmental costs into financial statements.
 
Received: 11 June 2024 / Accepted: 29 August 2024 / Published: 05 September 2024