bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of Individual Muscular Forces of the Lower Limb during Walking Using a Wearable Sensor System
Authors: Kim Suin , Ro Kyongkwan , Bae Joonbum
Published: May 2017

Although various kinds of methodologies have been suggested to estimate individual muscular forces, many of them require a costly measurement system accompanied by complex preprocessing and postprocessing procedures. In this research, a simple wearable sensor system was developed, combined with the inverse dynamics-based static optimization method. The suggested method can be set up easily and can immediately convert motion information into muscular forces. The proposed sensor system consisted of the four inertial measurement units (IMUs) and manually developed ground reaction force sensor to measure the joint angles and ground reaction forces, respectively. To verify performance, the measured data was compared with that of the camera-based motion capture system and a force plate. Based on the motion data, muscular efforts were estimated in the nine muscle groups in the lower extremity using the inverse dynamics-based static optimization. The estimated muscular forces were qualitatively analyzed in the perspective of gait functions and compared with the electromyography signal.
Numerical Feedback Stabilization with Applications to Networks
Authors: Göttlich Simone , Schillen Peter
Published: May 2017

The focus is on the numerical consideration of feedback boundary control problems for linear systems of conservation laws including source terms. We explain under which conditions the numerical discretization can be used to design feedback boundary values for network applications such as electric transmission lines or traffic flow systems. Several numerical examples illustrate the properties of the results for different types of networks.
Molecular Dynamics Study of the Factors Influencing the β-Cyclodextrin Inclusion Complex Formation of the Isomers of Linear Molecules
Authors: Alvira E.
Published: May 2017

The influence of the size, composition, and atomic distribution of linear guests on β-cyclodextrin inclusion complex formation is clarified by means of a molecular dynamics simulation at constant temperature. The intermolecular energy is modelled by a Lennard-Jones potential, where the molecular composition is represented by various parameters and by a continuum description of the guest and cavity walls. It is concluded that the parameters related to the atomic size require minimum values for the confinement of linear molecules inside the cavity. The isomer with optimal affinity for β-cyclodextrin as predicted by the free energy presents an asymmetrical molecular structure, and the position probability density shows that the isomer tends to insert the portion with largest atoms into the cavity, although the preferential binding site of the guest is not always located in regions of the host with maximum discriminatory power.
Deep Learning for Plant Identification in Natural Environment
Authors: Sun Yu , Liu Yuan , Wang Guan , Zhang Haiyan
Published: May 2017

Plant image identification has become an interdisciplinary focus in both botanical taxonomy and computer vision. The first plant image dataset collected by mobile phone in natural scene is presented, which contains 10,000 images of 100 ornamental plant species in Beijing Forestry University campus. A 26-layer deep learning model consisting of 8 residual building blocks is designed for large-scale plant classification in natural environment. The proposed model achieves a recognition rate of 91.78% on the BJFU100 dataset, demonstrating that deep learning is a promising technology for smart forestry.
A Survey of Routing Issues and Associated Protocols in Underwater Wireless Sensor Networks
Authors: Khalid Muhammad , Ullah Zahid , Ahmad Naveed , Arshad Muhammad , Jan Bilal , Cao Yue , Adnan Awais
Published: May 2017

Underwater wireless sensor networks are a newly emerging wireless technology in which small size sensors with limited energy and limited memory and bandwidth are deployed in deep sea water and various monitoring operations like tactical surveillance, environmental monitoring, and data collection are performed through these tiny sensors. Underwater wireless sensor networks are used for the exploration of underwater resources, oceanographic data collection, flood or disaster prevention, tactical surveillance systems, and unmanned underwater vehicles. Sensor nodes consist of a small memory, a central processing unit, and an antenna. Underwater networks are much different from terrestrial sensor networks as radio waves cannot be used in underwater wireless sensor networks. Acoustic channels are used for communication in deep sea water. Acoustic signals have many limitations, such as limited bandwidth, higher end-to-end delay, network path loss, higher propagation delay, and dynamic topology. Usually, these limitations result in higher energy consumption with a smaller number of packets delivered. The main aim nowadays is to operate sensor nodes having a smaller battery for a longer time in the network. This survey has discussed the state-of-the-art localization based and localization-free routing protocols. Routing associated issues in the area of underwater wireless sensor networks have also been discussed.
Acceleration of Image Segmentation Algorithm for (Breast) Mammogram Images Using High-Performance Reconfigurable Dataflow Computers
Authors: Milankovic Ivan L. , Mijailovic Nikola V. , Filipovic Nenad D. , Peulic Aleksandar S.
Published: May 2017

Image segmentation is one of the most common procedures in medical imaging applications. It is also a very important task in breast cancer detection. Breast cancer detection procedure based on mammography can be divided into several stages. The first stage is the extraction of the region of interest from a breast image, followed by the identification of suspicious mass regions, their classification, and comparison with the existing image database. It is often the case that already existing image databases have large sets of data whose processing requires a lot of time, and thus the acceleration of each of the processing stages in breast cancer detection is a very important issue. In this paper, the implementation of the already existing algorithm for region-of-interest based image segmentation for mammogram images on High-Performance Reconfigurable Dataflow Computers (HPRDCs) is proposed. As a dataflow engine (DFE) of such HPRDC, Maxeler’s acceleration card is used. The experiments for examining the acceleration of that algorithm on the Reconfigurable Dataflow Computers (RDCs) are performed with two types of mammogram images with different resolutions. There were, also, several DFE configurations and each of them gave a different acceleration value of algorithm execution. Those acceleration values are presented and experimental results showed good acceleration.
A Proinflammatory Effect of the β-Glucan from Pleurotus cornucopiae Mushroom on Macrophage Action
Authors: Minato Ken-ichiro , Ohara Akihiro , Mizuno Masashi
Published: May 2017

PCPS from P. citrinopileatus mushroom extract is a β-1,6-glucan possessing a proinflammatory effect on innate immune cells. The PCPS stimulated THP-1 macrophages to secrete significant levels of TNF. Moreover, the mRNA expressions of TNF and IL-1β were significantly enhanced by PCPS treatment. However, the PCPS did not induce to express both IL-12 and IL-10 mRNA in the macrophages. Next, the P. cornucopiae extract (containing mainly PCPS) treatment against mice showed significant increases in TNF and IL-1β mRNA expressions in the peritoneal macrophages of them. In this study, the expression levels of IFNγ mRNA in the spleen were almost the same between the extract- (PCPS-) treated group and control group. However, the expression of IL-4 mRNA showed a lower level in the extract-treated group than that in the control. Our results suggested that the PCPS could induce proinflammatory action in the immune response. In addition, the proinflammatory effect of the PCPS on THP-1 was enhanced by 5′-GMP-Na, while it was reduced by vitamin D2. These two compounds are majorly contained in the P. citrinopileatus mushroom. Therefore, these results suggested that the P. citrinopileatus mushroom might contain other immune regulative compounds, such as vitamin D2, as well as PCPS.
In Vitro Evaluation of Antimicrobial Activity of Alimentary Canal Extracts from the Red Palm Weevil,Rhynchophorus ferrugineusOlivier Larvae
Authors: Sewify Gamal H. , Hamada Hanan M. , Alhadrami Hani A.
Published: May 2017

The invasive red palm weevil,Rhynchophorus ferrugineusOlivier (Coleoptera: Curculionidae), is considered one of the world’s most devastating insect pests to palm trees. It was observed that larvae of this pest are able to inhibit microbial growth on the rearing media when they start feeding and this observation has led us to study the effect of red palm weevils on various microbial species. The antimicrobial effect of extracts from different parts of the alimentary canal on Gram positive bacteria (Enterococcus faecalisandStaphylococcus aureus), Gram negative bacteria (Escherichia coliandKlebsiellaspp.),Candida albicans,andPenicilliumsp. was tested using the agar well diffusion method. All extracts inhibited the tested microbial species. Foregut extracts had the greatest zones of growth inhibition.Enterococcus faecalis,Staphylococcus aureus,andPenicilliumsp. were significantly sensitive to the extracts and had the largest growth inhibition zones. It is concluded that the gut extracts contain potent antimicrobial activity and may provide a new source of antimicrobial peptides.
Effect of Gamma Rays onSophora davidiiand Detection of DNA Polymorphism through ISSR Marker
Authors: Wang Puchang , Zhang Yu , Zhao Lili , Mo Bentian , Luo Tianqiong
Published: May 2017

Sophora davidii(Franch.) Kom. ex Pavol is an important medicinal plant and a feeding scrub with ecological value. The effects of different gamma irradiation doses (20–140 Kr) on seed germination and seedling morphology were investigated inS. davidii, and intersimple sequence repeat (ISSR) markers were used to identify the DNA polymorphism among mutants. Significant variations were observed for seed germination, stem diameter, and number of branches per plant. The improved agronomic traits, such as stem diameter and number of branches per plant, were recorded at 80 Kr dose and 20 Kr dose for seed germination. ISSR analysis generated in total 183 scorable fragments, of which 94 (51.37%) were polymorphic. The percentage of polymorphism ranged from 14.29 to 93.33 with an average of 45.69%. Jaccard’s coefficients of dissimilarity varied from 0.6885 to 1.000, indicative of the level of genetic variation among the mutants. The constructed dendrogram grouped the entities into five clusters. Consequently, it was concluded that gamma rays irradiation of seeds generates a sufficient number of induced mutations and that ISSR analysis offered a useful molecular marker for the identification of mutants.
Physiotherapy in Parkinson’s Disease: Building ParkinsonNet in Czechia
Authors: Gal Ota , Srp Martin , Konvalinkova Romana , Hoskovcova Martina , Capek Vaclav , Roth Jan , Ruzicka Evzen
Published: May 2017

Objective. We conducted a questionnaire survey to investigate the availability and quality of physiotherapy (PT) for Parkinson’s disease (PD). Background. Despite evidence about the benefits of PT, there is no data regarding its use in Czechia. Methods. Questionnaires were sent to 368 PD patients seen in a single movement disorders centre within two years (inclusion criteria: idiopathic PD, Hoehn and Yahr stage <5, and residence in Prague) and to 211 physical therapists (PTs) registered in Prague. The patient questionnaire evaluated limitations in 6 core areas and in activities of daily living and inquired about experience with PT. The PTs questionnaire evaluated knowledge about PD, number of PD patients treated yearly, and details of therapy. Results. Questionnaires were returned by 248 patients and 157 PTs. PT was prescribed to 70/248 patients. The effects were satisfactory in 79% and lasted >3 months in 60/64. About half of the PTs have no experience with PD patients, 26% reported <3, and 5% see >10 yearly. The most widely used techniques were neurodevelopmental treatments. Conclusion. Present PD healthcare model in Czechia is suboptimal (low PT prescription, non-evidence-based PT). Implementation of European PT Guidelines for PD and the introduction of an efficient model of care are needed.
Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases
Authors: Żebrowska Agnieszka , Woźniacka Anna , Juczyńska Katarzyna , Ociepa Kamila , Waszczykowska Elżbieta , Szymczak Izabela , Pawliczak Rafał
Published: May 2017

Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. And the second aim of the study was the estimation of correlation between IL-36 and IL-17 and titers of specific antibodies in these diseases. Expression of IL-36 and IL-17 was detected in serum in all DH, BP, and PV samples. Serum levels of IL-36 and IL-17α were statistically higher in DH, BP, and PV groups as compared to the control group. IL-36α levels were statistically higher in DH patients, as compared to patients with PV and BP. Our results showed that IL-36 may be helpful in the diagnostic and monitoring of the activity of the disease. IL-36 may play a relevant role of enrolling eosinophils and neutrophils in DH, BP, and PV and finally provoke tissue injury.
A Study for Optimum Survey Method of Underwater Structure Using the Dual Sonar Sensor
Authors: Kim Youngseok , Lee Heungsu , Park Chul , Choi Sangsik
Published: May 2017

We have developed dual sonar equipment and an improved operating method for improving resolution in order to solve the problems of limitations of the optical equipment and the application method of SSS (side scan sonar) in the investigation of damage of underwater structures. We analyzed the influence factors of the resolution of sonar data through the comparison of resolution and data quality in indoor test. Also we confirmed the problems about the overlapping area of the dual sonar. Depth and distance were analyzed as major influencing factors for survey angle. Specimens were scanned while adjusting distance and towfish angle according to depth change in order to verify applicability of the developed dual sonar in the field experiment. Optimal resolution was found to be 3 cm in specimen spacing, and 20 sample data items were extracted. We developed the regression model based on the multiple regression analysis and developed the RealDualSONAR-DAQ tool, the dual sonar optimum operating method program based on proposed correlation equations. We can use the developed tools to get the value of the major influencing factors for dual sonar operation and obtain high quality sonar data to analyze damage of underwater structures.
Approximation of Functions on a Square by Interpolation Polynomials at Vertices and Few Fourier Coefficients
Authors: Zhang Zhihua
Published: May 2017

For a bivariate function on a square, in general, its Fourier coefficients decay slowly, so one cannot reconstruct it by few Fourier coefficients. In this paper we will develop a new approximation scheme to overcome the weakness of Fourier approximation. In detail, we will use Lagrange interpolation and linear interpolation on the boundary of the square to derive a new approximation scheme such that we can use the values of the target function at vertices of the square and few Fourier coefficients to reconstruct the target function with very small error.
Applying Environmental Isotope Theory to Groundwater Recharge in the Jiaozuo Mining Area, China
Authors: Huang Pinghua , Wang Xinyi
Published: May 2017

This study establishes the surface water evaporation line in theory and numerically simulates the δD and δ18O value distribution interval of the recharge source of deep groundwater in the Jiaozuo mining area. The recharge elevation is calculated based on hydrogen and oxygen isotope tracer theory. Theoretical calculation and experimental data indicate that the surface water evaporation line in the study area in theory is almost the same as the measured surface data-fitting line. A significant linear relationship is identified between δ18O and the elevation of spring outcrop. The topography increases per 100 m, and the δ18O value reduces by 0.23‰ on average. The δ18O value is converted into formula to calculate the groundwater recharge elevation, which is approximately from 400 to 800 m. The measured tritium values of karst groundwater are greater than 3 TU. The second factor score is a fraction distribution in shallow groundwater and negative fraction distribution in spring and deep groundwater, which indicates that the Northern Taihang Mountain is the main recharge area, where carbonate-exposed areas exist. The research conclusion holds a certain value for the flood evaluation of local coal mines.
An Alternative Approach to the Terminal Management of Ogilvie Syndrome
Authors: Galban Daniel , Baiel Joshua J.
Published: May 2017

Ogilvie syndrome is defined as colonic pseudo-obstruction due to nonmechanical causes. Mortality of nearly 50% is associated with perforation of the distended, pseudo-obstructed colon. While conservative medical therapy has proven to be beneficial in a majority of cases, >3% of patients have significant distention or perforation of the colon that warrants surgical resection. The case of a 48-year-old male with progressive abdominal discomfort and distention 12 days following knee replacement surgery is presented. He was subsequently diagnosed with colonic pseudo-obstruction and definitively treated with subtotal colectomy and colostomy. We propose that a more conservative approach to treatment of colonic pseudo-obstruction may prevent the need for colostomy, significantly improving quality of life.
Nilotinib-Induced Acute Pancreatitis in a Patient with Chronic Myeloid Leukemia
Authors: Patel Vihang , Pattisapu Anil , Attia Karim , Weiss John
Published: May 2017

Nilotinib, a second-generation tyrosine kinase inhibitor, is used for treatment of chronic myeloid leukemia (CML); it has been widely used especially for imatinib-resistant CML. Despite being a novel drug in this therapeutic class, it has the potential to be harmful. We present the case of an elderly woman who developed life-threatening acute pancreatitis as an adverse event after having started the drug. There is only one reported case in the literature of nilotinib-induced acute pancreatitis. The purpose of this case report is to educate physicians who prescribe this medication to be aware of potential life-threatening adverse events. As more and more therapies are available, physicians should be aware of potential effects of cancer treatment that could be life-threatening to patients.
Sweet’s Syndrome Successfully Treated with Granulocyte and Monocyte Adsorption Apheresis
Authors: Fujii Asami , Mizutani Yoko , Hattori Yuki , Takahashi Tomoko , Ohnishi Hidenori , Yoshida Shozo , Seishima Mariko
Published: May 2017

Sweet’s syndrome is a neutrophilic dermatosis characterized by an abrupt onset of painful erythematous lesions showing neutrophilic infiltrates in the dermis. Fever and an elevated neutrophil level are generally observed. Sweet’s syndrome may be idiopathic, malignancy-associated, or drug-induced (mainly involving granulocyte colony-stimulating factor (G-CSF) administration). Although systemic corticosteroids are usually effective, the symptoms of Sweet’s syndrome recur in some refractory cases. Herein, we report a case of a 55-year-old Japanese woman with recurrent symptoms of fever (>39°C) and painful erythematous lesions on her four extremities, trunk, and neck. Laboratory findings revealed leukocytosis and high levels of C-reactive protein (CRP) and G-CSF. She was diagnosed with a recurrence of Sweet’s syndrome, and was exclusively treated with granulocyte and monocyte adsorption apheresis (GMA) therapy once a week for 3 consecutive weeks. After the first session of GMA therapy, all symptoms including the erythematous lesions and fever were completely resolved, and serum G-CSF level was reduced. Leukocyte count, neutrophil count, serum amyloid A protein, and CRP levels were restored within normal ranges by 2 weeks. Thus, GMA therapy can successfully treat a patient with recurrent Sweet’s syndrome, potentially related to the restoration of elevated serum G-CSF levels.
A Symptomatic Coffee Bean: Acute Sigmoid Volvulus
Authors: Scharl Michael , Biedermann Luc
Published: May 2017

An acute sigmoid volvulus is due to the torsion of the sigmoid colon around its mesenteric axis. It mainly occurs in elderly patients and represents an abdominal emergency requiring urgent treatment. A 53-year-old male patient with severe craniocerebral injury and traumatic subarachnoidal bleeding 3 weeks prior presented on the ward with distended abdomen without abdominal pain, muscular defense, or resistances. He featured large volume diarrhea within the last few hours without signs of bleeding. A plain abdominal X-ray demonstrated a coffee bean sign indicating a sigmoid volvulus. A consequent CT scan of the abdomen revealed a deep outlet obstruction with massively dilated, elongated and twisted loop of the sigmoid colon and no signs of perforation. We performed emergency colonoscopy under the assumption of an acute sigmoid volvulus. After careful insertion of the endoscope completely refraining from insufflation of air or CO2, endoscopic reposition of the sigma could be achieved and a colonic drainage was placed over an inserted guide wire up to the proximal transverse colon. No relapse occurred and a diagnostic colonoscopy after 4 weeks revealed no tumor or polyps. Our report describes a classic case of acute sigmoid volvulus and undermines the potential of colonoscopy as conservative primary treatment of choice.
Epidemiology and Molecular Biology of Head and Neck Cancer
Authors: Jou Adriana , Hess Jochen
Published: May 2017

Head and neck cancer is a common and aggressive malignancy with a high morbidity and mortality profile. Although the large majority of cases resemble head and neck squamous cell carcinoma (HNSCC), the current classification based on anatomic site and tumor stage fails to capture the high level of biologic heterogeneity, and appropriate clinical management remains a major challenge. Hence, a better understanding of the molecular biology of HNSCC is urgently needed to support biomarker development and personalized care for patients. This review focuses on recent findings based on integrative genomics analysis and multi-scale modeling approaches and how they are beginning to provide more sophisticated clues as to the biological and clinical diversity of HNSCC.
Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography
Authors: Reichetzeder Christoph , Heunisch Fabian , Einem Gina von , Tsuprykov Oleg , Kellner Karl-Heinz , Dschietzig Thomas , Kretschmer Axel , Hocher Berthold
Published: May 2017

Background/Aims: Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application. Methods: In this prospective cohort study 245 patients undergoing coronary angiography were analyzed. Blood samples were obtained at baseline, 24h and 48h after contrast media (CM) application to diagnose CI-AKI. Patients were followed for 120 days for adverse clinical events including death, the need for dialysis, and a doubling of plasma creatinine. Occurrence of any of these events was summarized in the combined endpoint MAKE. Results: Preinterventional plasma kynurenine was not associated with CI-AKI. Patients who later developed MAKE displayed significantly increased preinterventional plasma kynurenine levels (p<0.0001). ROC analysis revealed that preinterventional kynurenine is highly predictive for MAKE (AUC=0.838; p<0.0001). The optimal cutoff was found at ≥3.5 µmol/L Using this cutoff, the Kaplan-Meier estimator demonstrated that concentrations of plasma kynurenine ≥3.5 µmol/L were significantly associated with a higher prevalence of MAKE until follow up (p<0.0001). This association remained significant in multivariate Cox regression models adjusted for relevant factors of long-term renal outcome. Conclusion: Preinterventional plasma kynurenine might serve as a highly predictive biomarker for MAKE up to 120 days after coronary angiography.
Towards the Manufacture of Megakaryocytes and Platelets for Clinical Application
Authors: Baigger Anja , Blasczyk Rainer , Figueiredo Constanca
Published: May 2017

Platelet transfusions are used in standard clinical practice to prevent hemorrhage in patients suffering from thrombocytopenia or platelet dysfunctions. Recently, a constant rise on the demand of platelets for transfusion has been registered. This may be associated with several factors including demographic changes, population aging as well as incidence and prevalence of hematological diseases. In addition, platelet-regenerative properties have been started to be exploited in different areas such as tissue remodeling and anti-cancer therapies. These new applications are also expected to increase the future demand on platelets. Thus, in vitro generated platelets may constitute a highly desirable alternative to meet the rising demand on platelets. Several factors have been considered in the road trip of producing in vitro megakaryocytes and platelets for clinical application. From selection of the cell source, differentiation protocols and culture conditions to the design of optimal bioreactors, several strategies have been proposed to maximize production yields while preserving functionality. This review summarizes new advances in megakaryocyte and platelet differentiation and their production upscaling.
Evaluation of Prostate Imaging Reporting and Data System Classification in the Prediction of Tumor Aggressiveness in Targeted Magnetic Resonance Imaging/Ultrasound-Fusion Biopsy
Authors: Borkowetz Angelika , Platzek Ivan , Toma Marieta , Renner Theresa , Herout Roman , Baunacke Martin , Laniado Michael , Baretton Gustavo B. , Froehner Michael , Zastrow Stefan , Wirth Manfred P.
Published: May 2017

Objectives: The study aimed to evaluate the prediction of Prostate Imaging Reporting and Data System (PI-RADS) with respect to the prostate cancer (PCa) detection rate and tumor aggressiveness in magnetic resonance imaging (MRI)/ultrasound-fusion-biopsy (fusPbx) and in systematic biopsy (sysPbx). Materials and Methods: Six hundred and twenty five patients undergoing multiparametric MRI were investigated. MRI findings were classified using PI-RADS v1 or v2. All patients underwent fusPbx combined with sysPbx (comPbx). The lesion with the highest PI-RADS was defined as maximum PI-RADS (maxPI-RADS). Gleason Score ≥7 (3 + 4) was defined as significant PCa. Results: The overall PCa detection rate was 51% (n = 321; 39% significant PCa). The detection rate was 43% in fusPbx (n = 267; 34% significant PCa) and 36% in sysPbx (n = 223; 27% significant PCa). Nine percentage of significant PCa were detected by sysPbx alone. A total of 1,162 lesions were investigated. The detection rate of significant PCa in lesions with PI-RADS 2, 3, 4, and 5 were 9% (18/206), 12% (56/450), 27% (98/358), and 61% (90/148) respectively. maxPI-RADS ≥4 was the strongest predictor for the detection of significant PCa in comPbx (OR 2.77; 95% CI 1.81-4.24; p < 0.005). Conclusions: maxPI-RADS is the strongest predictor for the detection of significant PCa in comPbx. Due to a high detection rate of additional significant PCa in sysPbx, fusPbx should still be combined with sysPbx.
Right TraC™ Post-Hospitalization Care Transitions Program to Reduce Readmissions for Hemodialysis Patients
Authors: Wingard Rebecca L. , McDougall Kathryn , Axley Billie , Howard Andrew , O''Keefe Cathleen , Armistead Nancy , Lynch Janet R. , Rosen Sophia , Usvyat Len , Maddux Franklin W.
Published: May 2017

Background: Hemodialysis (HD) patients have high hospitalization rates. This nonrandomized trial tested the effect of a bundle of renal-specific “Right TraC™” strategies on 30-day all-cause readmission rates and, secondarily, 90-day readmissions and overall admissions among HD patients. Methods: Twenty-six Fresenius clinics in West Virginia, Ohio, and Kentucky participated in the interventions. Eighteen matched clinics served as controls; intervention clinics also served as their own controls. We deployed the intervention in 3 incremental phases focused on patient information exchange, post-hospital follow-up, and telephonic case management. Thirty-day hospital readmissions per patient year (ppy) were calculated by dividing the total number of readmissions within 30 days of index admission by the total number of patient-years in baseline (2012) and remeasurement (2014) periods. We also compared readmission rates from 2010 to 2015. We used repeated measures Poisson regression to compare outcomes between groups and time periods. Results: From 2012 to 2014, 30-day all-cause readmissions ppy declined for Right TraC clinics (from 0.88 to 0.66 [p < 0.001]; for controls, from 0.73 to 0.61 [p = 0.16]). Difference in change between groups was nonsignificant (p = 0.26). Overall admissions ppy declined: for Right TraC clinics from 2.51 to 1.97 (p < 0.001); for controls from 2.14 to1.92 (p = 0.21); difference in change between groups was significant (p = 0.01). For 2010, 2011, and 2012, Right TraC clinic 30-day readmissions ppy were unchanged: 0.89, 1.00, 0.88 (p = 0.61 and p = 0.49); they declined to 0.66 (p < 0.001) in 2014 (intervention year); rose to 0.70 (p = 0.06) in 2015 (interventions discontinued). Conclusion: We conclude that Right TraC interventions may have been helpful in reducing hospital readmission rates.
Emergence of CD43-Expressing Hematopoietic Progenitors from Human Induced Pluripotent Stem Cells
Authors: Kessel Katharina U. , Bluemke Anika , Schöler Hans R. , Zaehres Holm , Schlenke Peter , Dorn Isabel
Published: May 2017

Background: The ex vivo generation of human hematopoietic stem cells (HSCs) with long-term repopulating capacity and multi-lineage differentiation potential represents the holy grail of hematopoiesis research. In principle, human induced pluripotent stem cells (hiPSCs) provide the tool for both studying molecular mechanisms of hematopoietic development and the ex vivo production of ‘true' HSCs for transplantation purposes and lineage-specific cells, e.g. red blood cells, for transfusion purposes. CD43-expressing cells have been reported as the first hematopoietic cells during development, but whether or not these possess multilineage differentiation and long-term engraftment potential is incompletely understood. Methods: We performed ex vivo generation of hematopoietic cells from hiPSCs using an embryoid body(EB)-based, xeno-product-free differentiation protocol. We investigated the multilineage differentiation potential of different FACS-sorted CD43-expressing cell subsets by colony-forming assays in semisolid media. Further, erythroid differentiation was investigated in more detail using established protocols. Results: By using CD43, we were able to measure hematopoietic induction efficiency during hiPSC-derived EB differentiation. Further, we determined CD43+ cells as the cell population of origin for in vitro erythropoiesis. Furthermore, colony formation demonstrates that the multipotent hematopoietic stem and progenitor cell fraction is particulary enriched in the CD43hi CD45+ population.
Arterial Stiffness is an Independent Risk Factor for Anemia After Percutaneous Native Kidney Biopsy
Authors: Tanaka Keiko , Kitagawa Masashi , Onishi Akifumi , Yamanari Toshio , Ogawa-Akiyama Ayu , Mise Koki , Inoue Tatsuyuki , Morinaga Hiroshi , Uchida Haruhito A. , Sugiyama Hitoshi , Wada Jun
Published: May 2017

Background/Aims: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. Method: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a ≥10% decrease in hemoglobin [Hb] after biopsy). The brachial-ankle pulse wave velocity (baPWV) was measured to evaluate arterial stiffness. Results: This study included 462 patients (male, n=244; female, n=218). Anemia (defined above) was observed in 54 patients (11.7%). The risk of anemia was higher in women, older patients, and patients with lower serum albumin, lower eGFR and lower diastolic blood pressure after biopsy. We then performed a further analysis of 187 patients whose baPWV data were available. Multivariate analysis revealed that a higher baPWV was an independent risk factor for anemia. ROC analysis for predicting anemia found that a baPWV value of 1839 cm/s had the best performance (AUC 0.689). Conclusion: An increased baPWV may be a more valuable predictor of bleeding than any of the other reported risk factors.
КЛІНІКО-ГЕНЕТИЧНІ ЗАКОНОМІРНОСТІ ФОРМУВАННЯ ТА ПЕРЕБІГУ БРОНХІАЛЬНОЇ АСТМИ В ДИТЯЧОМУ ВІЦІ
Authors: Voloshyn S. B.
Published: May 2017

Досліджено особливості перебігу бронхіальної астми серед пацієнтів з обтяженим алергологічним анамнезом із різними генотипами Arg16Gly гена β2-адренорецепторів. Проведено аналіз асоціації поліморфізму досліджених генів із особливостями алергоанамнезу, а також виявлено кореляційну залежність рівня IgE від супутніх алергічних патологій. У ході дослідження встановлено переважання гетерозиготного варіанта Arg/Gly (42,57 %) та гомозиготного варіанта Gly/Gly (43,56 %) гена ADRβ2-рецепторів, а також підтверджено вплив обтяженого алергоанамнезу на реалізацію бронхіальної астми у дітей.
МОДЕЛІ ОЦІНЮВАННЯ ТЕСТОВИХ ЗАВДАНЬ РІЗНИХ ТИПІВ ТА ВИЗНАЧЕННЯ ЇХ РІВНЯ СКЛАДНОСТІ
Authors: Martsenyuk V. P. , Handzyuk N. M.
Published: May 2017

The paper is devoted to the test items marking technology and distribution of different types items by the levels of complication. At distribution of test items on complication levels it is offered to use the integrated functional model which allows to apply different ways of the test items distribution included in the test.
ПОБУДОВА МАТЕМАТИЧНОЇ МОДЕЛІ СКЛАДНОГО РУХУ ФЛАКОНІВ НА ЛІНІЯХ РОЗЛИВУ ЛІКІВ ФАРМАЦЕВТИЧНОЇ ПРОМИСЛОВОСТІ
Authors: Kravets N. О.
Published: May 2017

The  mathematical model of the complex product motion along the lateral lines at the plate conveyers of the bottle lines is presented in the artcle. The experimental evaluation of the gained theoretical dependence is suggested.   The calculation results coordinate well with the modelling and experiment resuls.
ПІДХІД НА ОСНОВІ АКТУАРНИХ МАТЕМАТИЧНИХ МОДЕЛЕЙ ДО ЗАДАЧ СТРАХОВОЇ МЕДИЦИНИ
Authors: Martsenyuk V. P. , Klymuk N. Ya. , Andrushchak I. Ye.
Published: May 2017

In this work there is developed an approach based on actuarial mathematical models for the problems of health insurance. Models are presented in terms of Kolmogorov and Thiele equations.
КОНЦЕПТУАЛЬНА СХЕМА ПОБУДОВИ МОДЕЛІ ЗАГАЛЬНООБОВ’ЯЗКОВОГО ДЕРЖАВНОГО СОЦІАЛЬНОГО МЕДИЧНОГО СТРАХУВАННЯ В УКРАЇНІ
Authors: Нorshkov Ye. V.
Published: May 2017

In this article there has been presented the conceptual scheme of the model structure of compulsory for all state social medical insurance. There has been proposed the calculation model of insurance payment using risk extra charge and dispersion.
ОБГРУНТУВАННЯ ФАРМАКОКІНЕТИЧНИХ ПОКАЗНИКІВ ЛІКАРСЬКИХ ПЛІВОК ДЛЯ ЗАДАЧ МАТЕМАТИЧНОГО МОДЕЛЮВАННЯ
Authors: Tymchenko І. М. , Davtian L. L. , Vlasenko І. О. , Yeroshenko S. S. , Babintseva L. Yu.
Published: May 2017

The search of indices is conducted for creation of model at the pharmacokinetic study of medicinal means.By methods of in vivo with the use of a single-chamber model, pharmacokinetic research has been carried out of the medicinal films containing metronidazole. It has been established, that films have a local effect because at the moment the flow of extrication of the substances from the films is greater than a penetration flow through natural biological barriers of an organism.
ІНФОЛОГІЧНА МОДЕЛЬ РЕАБІЛІТАЦІЙНО-ВІДНОВЛЮВАНОГО ПРОЦЕСУ ХВОРИХ З ПАТОЛОГІЄЮ ОПОРНО-РУХОВОГО АПАРАТУ ТА ДІЮЧИМИ РИЗИКАМИ
Authors: Azarhov O. Yu.
Published: May 2017

In the article the modern conception of process of rehabilitation-restoration cure of patients with violations of locomotive system is represented as a five-level informative-logical model taking into account the endogenous and exogenous risks, that allows optimizing functional and social patients’ readaptation.
МОЖЛИВОСТІ АНАЛІЗУ ВАРІАБЕЛЬНОСТІ РИТМУ СЕРЦЯ В ДІАГНОСТИЦІ ЕМОЦІЙНОГО СТАНУ ЛЮДИНИ
Authors: Chaykovskyi І. , Kalnysh V. , Yena Т. , Yena А. , Vyrovyi Yu. , Ketko М. , Frolov Yu. , Budnyk V.
Published: May 2017

The is presented the development of method for evaluation of emotional state of man, what suitable for use at the workplace based on analysis of heart rate (HR) variability.28 healthy volunteers were examined. 3 audiovisual clips were consistently presented on the display of the personal computer for each of them. One clip contained information originating the positive emotions, the second one – negative emotions, the third one – neutral. All possible pairs of the emotional states were analysed with help of one- and multi-dimensional linear discriminant analysis based on HR variability.Showing the emotional video-clips (of both signs) causes reliable slowing of HR frequency and also some decreasing of HR variability. In addition, negative emotions cause regularizing and simplification of structural organization of heart rhythm. Accuracy of discrimination for pair “emotional – neutral” video clips was 98 %, for pair “rest – neutral” was 74 %, for pair “positive – negative” was 91 %.Analysis of HR variability enables to determine the emotional state of observed person at the workplace with high reliability.
ОСНОВНІ ВИМОГИ ДО СТРУКТУРИ ТИПОВИХ МЕДИЧНИХ ІНФОРМАЦІЙНИХ СИСТЕМ В УПРАВЛІННІ ОХОРОНОЮ ЗДОРОВ'Я
Authors: Mintser О. P. , Banchuk M. V. , Babintseva L. Yu. , Yarmenchuk І. А. , Diachenko S. O.
Published: May 2017

In modern development of health care for providing proper quality of medicare there is a necessity in accumulation and analysis of data during the long period, application of electronic and consulting models. The presented work determines basic principles of construction of the informative systems for optimization of management of health care establishments, first of all, at making decisions. Basic tasks and requirements to the informative systems on regional and local levels are considered. It is proven that typical structures of the medical informative systems must have possibilities of risks monitoring for patients and decisions as to danger identification for managers.
СТАТИСТИЧНИЙ АНАЛІЗ ЛАЗЕРНИХ ПОЛЯРИЗАЦІЙНИХ ЗОБРАЖЕНЬ ПЛАЗМИ КРОВІ В ДІАГНОСТИЦІ ПАТОЛОГІЇ МОЛОЧНИХ ЗАЛОЗ
Authors: Zabolotna N. I. , Oliinychenko B. P.
Published: May 2017

There are changes tendentious statistical moments of two-dimensional distribution of azimuth and ellipticity of polarization of a laser image of human blood plasma. Evaluation was carried out under the assumption that small and high level of birefringence  reflects the state plasma "healthy person" and «pathology of mammary glands».
ОГЛЯД ПОЛІГРАФІВ ТА МЕТОДІВ ОБРОБКИ ПСИХОФІЗІОЛОГІЧНОЇ ІНФОРМАЦІЇ
Authors: Sverstiuk А. S.
Published: May 2017

The paper contains a review of existing polygraph, psychophysiological methods of information, processing there are discussed the means of the modern polygraph software.
ПРО КОНЦЕПТУАЛЬНІ ПІДХОДИ ДО ОРГАНІЗАЦІЇ ДИСТАНЦІЙНОГО НАВЧАННЯ ЗА СПЕЦІАЛЬНІСТЮ "СЕСТРИНСЬКА СПРАВА"(БАКАЛАВР)
Authors: Martsenyuk V. P. , Usynska O. S. , Sverstyuk A. S.
Published: May 2017

The article reviews the main conceptual approaches to organization of distance learning in nursing (Rn-to-BSN program) at Ternopil State Medical University. Techniques for practicals and lectures in distance learning are described.
ІНФОРМАЦІЙНІ ТЕХНОЛОГІЇ В ЗАБЕЗПЕЧЕННІ ЕФЕКТИВНОСТІ ДОПОМІЖНОГО ЛАЗЕРНОГО ХЕТЧИНГУ
Authors: Denysenko S. V.
Published: May 2017

In the article the problems of effectiveness increasing of using of assisted laser hatching to enhance the quality of the IVF laboratory was analyzed.
СТРУКТУРНО-ЛІНГВІСТИЧНИЙ ПІДХІД ДО КЛАСИФІКАЦІЇ КАРДІОРИТМОГРАМ У СПОРТСМЕНІВ ВИСОКОЇ КВАЛІФІКАЦІЇ В ПОЧАТКОВУ ФАЗУ АДАПТАЦІЇ ДО УМОВ СЕРЕДНЬОГІР'Я
Authors: Ilyin V. M. , Cherkes L. I. , Myhaylovych М. , Portnichenko V. I. , Yahnytsia І. А.
Published: May 2017

We have implemented the structural and linguistic approach to study the cardiac rhythm variability of athletes competing in speed-power disciplines. The athletes were subjected to altitude-induced hypoxia. We have derived the formula that describes the adaptation reactions and the key characteristics of the cardiac rhythm spectrum, such as frequency and amplitudes of main spectral maxima.
ТЕХНОЛОГІЧНІ ОСНОВИ ПРОВЕДЕННЯ ТЕЛЕМЕДИЧНИХ КОНСУЛЬТАЦІЙ
Authors: Tahere H. , Yarmenchuk І. А.
Published: May 2017

The issues of the use of telemedical technologies for providing of curative and diagnostic consultations, decisions of administrative, educational and scientific measures in the sphere of public health are considered. Extreme importance of the use of national and international standards of obtained, processed and transmitted information is underlined.
ІНФОРМАЦІЙНЕ ЗАБЕЗПЕЧЕННЯ СТРАТЕГІЇ ВИЗНАЧЕННЯ ОПТИМАЛЬНОЇ ТАКТИКИ ХІРУРГІЧНОГО ЛІКУВАННЯ ХВОРИХ З ПРОЛІФЕРАТИВНОЮ ДІАБЕТИЧНОЮ РЕТИНОПАТІЄЮ
Authors: Ruban А. М.
Published: May 2017

The article describes the information model in detection of any factors that may predict visual outcome after vitrectomy for proliferative diabetic retinopathy.
ПОРІВНЯЛЬНИЙ АНАЛІЗ ПОКАЗНИКІВ ЦЕНТРАЛЬНОЇ ГЕМОДИНАМІКИ У СПОРТСМЕНІВ-ДЗЮДОЇСТІВ ВИСОКОЇ КВАЛІФІКАЦІЇ
Authors: Oleksenko І. М.
Published: May 2017

Research and analysis of indices of central hemodynamics are conducted in 101 sportsmen of high qualification, members of collapsible command of Ukraine on judo. The sizes of laboratory indices of integral reovathografy are set, characterized for the sportsmen-judoists divided on sexual distinction and gravimetric categories.
ПРО НЕОБХІДНІСТЬ ОЦІНЮВАННЯ РІВНЯ ЕМОЦІЙНОГО СТРЕСУ ПРИ ПРОГНОЗУВАННІ ВИНИКНЕННЯ ІНСУЛЬТУ
Authors: Azarkhov O. Yu. , Sierhieieva V. V. , Bielousova О. V. , Sheremeta N. O.
Published: May 2017

The article deals with various kinds of stress and emotional state and their influence on the prediction of apoplectic stroke. The subjective evaluation of the stress state of doctors and patients was investigated.
ІНФОРМАЦІЙНО-ТЕХНОЛОГІЧНІ ПРОБЛЕМИ ОРГАНІЗАЦІЇ ТЕЛЕМЕДИЧНИХ КОНСУЛЬТАЦІЙ
Authors: Mintser O. P. , Krasnov V. V. , Takhere H.
Published: May 2017

The ways of formalization of curatively-diagnostic process are considered for diminishing of amount of the possible errors, related to the insufficient inspection of the patient, curvatures of diagnostic information, erroneous interpretation of the received information.
ПРОГНОЗУВАННЯ ПЕРЕБІГУ ХІРУРГІЧНОГО ЛІКУВАННЯ ДИФУЗНОГО ПЕРИТОНІТУ З УРАХУВАННЯМ КІЛЬКІСНОЇ ОЦІНКИ ФАКТОРІВ РИЗИКУ
Authors: Churpiy І. К.
Published: May 2017

Explored the possibility of quantitative assessment of risk factors of complications in the treatment of diffuse peritonitis. Highlighted 53 groups of features that are important in predicting the course of diffuse peritonitis. The proposed scheme of defining the risk of clinical course of diffuse peritonitis can quantify the severity of the source of patients and in most cases correctly predict the results of treatment of disease.
ПЕРСПЕКТИВИ ЗАСТОСУВАННЯ ТЕЛЕМЕДИЦИНИ В ТРАВМАТОЛОГІЇ ТА ОРТОПЕДІЇ У ТЕРНОПІЛЬСЬКІЙ ОБЛАСТІ
Authors: Kovalchuk O. L. , Kulyanda I. S. , Smorshchok Yu. S. , Dumanets O. V. , Martsenyuk V. P.
Published: May 2017

On the basis of the analytical review of publications on the use of telemedicine in traumatology and orthopedics it is shown the clinical, economic and organizational effectiveness of different possibilities of telemedicine systems in all phases of orthopedic and trauma care.
САНОЦЕНТРИЧНА СТРАТЕГІЯ ОХОРОНИ ЗДОРОВ'Я: ПРЯМИЙ ШЛЯХ ДО ЗДОРОВ'Я НАСЕЛЕННЯ
Authors: Apanasenko G. L.
Published: May 2017

We discuss the fundamental position of the essence of life and health as a manifestation of the transformation of solar energy into other forms of energy (thermal, mechanical, electrical, etc.). It is alleged that the efficiency of intracellular energy production as an expression of mitochondrial function (the final stage of the transformation of solar energy) is a measure of the body's resistance to internal and external negative influences. There is a level of energy production above which neither endogenous risk factors, nor the disease are registered. It was given quantitative characteristic named «safe level of health». It is postulated (in addition to the «sickness industry» - the Ministry of Health institutions) the need to form the «health industry», based on the preservation and improvement of energy potential biosystems.
ОСОБЛИВОСТІ ЗАБЕЗПЕЧЕННЯ ЯКОСТІ ПІДГОТОВКИ РЕГУЛЬОВАНИХ ПРОФЕСІЙ У РАМКАХ ДЕРЖАВНО-ПРИВАТНОГО ПАРТНЕРСТВА В ОСВІТІ ТА Е-МЕДИЦИНІ
Authors: Sinyenko N. О. , Zagorii G. V. , Mokhnachov S. I.
Published: May 2017

The advent of e-medicine, the processes of state-private partnership and the associated rapid increase of non-formal education centers net, especially in solving problems to ensure the regulated professions, requires the creation of fundamentally new approaches to the design of the education system. The problems of the quality of training of specialists related to the class of «regulated professions» are examined. It is obtained the idea that in a period of rapid development of the subject areas the only mechanism that determines the need for additional education, as well as its scope and quality, is currently the use of ontological models and knowledge of the subject and associated areas.
ОНТОЛОГІЧНІ ІНТЕРАКТИВНІ СИСТЕМИ ЗНАНЬ -ПАРАДИГМА РОЗВИТКУ МОБІЛЬНОЇ МЕДИЦИНИ
Authors: Stryzhak O. Ye. , Mintser О. P. , Babintseva L. Yu.
Published: May 2017

It describes the approaches and tools of formation of the ontological systems of medical records. The conditions of their creation on the basis of the relevant provisions of partially ordered medical theories are defined. There are determined such tools as term field of medical document, taxonomy, reducer of multiple relations between the concepts of the theory, the provisions of which are reflected in a medical document. Documents ontologies are considered as network-centric interactive medical knowledge systems. Examples of dynamic presentation of the state of physicians and patients interaction with ontological medical document system are presented.
ПРОБЛЕМА ЗАХИСТУ ТЕЛЕМЕДИЧНОЇ ІНФОРМАЦІЇ: НОРМАТИВНО- ПРАВОВІ ТА ОРГАНІЗАЦІЙНІ АСПЕКТИ З ДОСВІДУ РЕСПУБЛІКИ ПОЛЬЩА
Authors: Martsenyuk V. P. , Klymuk N. Ya. , Gvozdetska I. S.
Published: May 2017

In the work the problem of telemedicine information security is studied. Classification of medical data from viewpoint of existing standards for information security in processes of both users authentication and security of processing medical information is fulfilled. Topics of information security in processes of both closed and open treatment are studied in details. There is presented existing legislative documents with respect to telemedicine information security of Republic of Poland.