bluuebunny/crossref_metadata_2025 huggingface dataset:
The negotiation of authorial persona in dissertations literature review and discussion sections
Authors: Fendri Emna , Triki Mounir
Published: April 2022

Writing at a postgraduate level is not only meant to obtain a degree in a specific field but also, and more importantly, to secure that ones research is published nationally as well as internationally. In other words, conducting research is first and foremost about making ones distinctive voice heard. Using Martin and Whites (2005) appraisal framework, the present study examines the way Tunisian MA and PhD EFL researchers in applied linguistics establish a dialogue with the reader as a persuasive tool in their texts. The comparison is meant to unveil cross-generic differences in authorial voice manifestation that distinguish postgraduate writers at different degrees. A corpus of 20 Literature Review and 20 Discussion sections taken from 10 MA and 10 PhD dissertations written in English by Tunisian EFL writers is qualitatively and quantitatively explored. Linguistic markers denoting the writers stance are identified in the corpus and are qualitatively studied using the engagement subsystem to qualify the utterance as dialogically contractive or expansive. A quantitative analysis then compares how dialogicality is manifested across the degrees and sections using SPSS. The results show that the negotiation of voice seems to be more problematic for MA researchers in both sections in comparison to PhD writers. Dialogic contraction in the MA subcorpus conveys a limited authorial positioning in the Literature Review section and a failure to stress personal contribution in the Discussion section. PhD researchers frequent reliance on expansion in both sections displays their academic maturity. The critical evaluation of previous works in the Literature Review and the claim for authorial ownership in the Discussion section distinguish them from MA writers. The comparison not only stresses the strengths that distinguish PhD writers but also points out problematic instances in establishing a dialogue with the audience in postgraduate writings. The study findings can be used to consider EFL researchers production in pedagogical contexts in terms of identity manifestation and stance-taking strategies across the different sections of the dissertation.
Keunikan Al-Qur’an Al-Karim dan Terjemahan Bebas Bersajak dalam Bahasa Aceh Karya Teungku Mahjiddin Yusuf
Authors: Muthalib Salman Abdul , Nurlaila Nurlaila , Safriani Safriani
Published: April 2022

In general, the translation of the Koran is done in the national language so that it can be understood by the general public, but one of the Acehnese clerics, Tgk. H. Mahjiddin Jusuf in his work Al-Karim Qur'an and Free Translation of Rhyme in Acehnese translates the Qur'an in Acehnese and in the form of nazam. Based on this phenomenon, it is necessary to conduct a study to see the uniqueness and characteristics, advantages and disadvantages of the work. This research is a literature study with the data sources being the Qur'an and the Free Translation of Rhyme in Acehnese which was analyzed descriptively. The results showed that the interpretation made by Mahjiddin Jusuf was lughawi (language), because he translated the Koran by expressing words poetically. In terms of method, this work is included in the ijmali interpretation method, because it explains the meaning of the Qur'an globally. The translation of the Koran also has regional and literary characteristics, because it expresses the meaning of the Koran in the regional language (Aceh) in the form of a-b-a-b rhymes with an Acehnese cultural approach. Pada umumnya penerjemahan Alquran dilakukan dalam bahasa nasional sehingga dapat dipahami khalayak ramai, namun salah seorang ulama Aceh Tgk. H. Mahjiddin Jusuf dalam karyanya Alquran al-Karim dan Terjemahan Bebas Bersajak dalam Bahasa Aceh menerjemahkan Alquran dalam bahasa Aceh dan dalam bentuk nazam. Berdasarkan fenomena ini, maka perlu dilakukan kajian untuk melihat keunikan dan karakteristiknya, kelebihan dan kekurangan karya tersebut. Penelitian ini merupakan studi kepustakaan dengan sumber datanya Alquran dan Terjemahan Bebas Bersajak dalam Bahasa Aceh yang dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa penafsiran yang dilakukan Mahjiddin Jusuf bercorak lughawi (bahasa), karena menerjemahkan Alquran dengan mengungkapkan kata-kata secara puitis. Dari segi metode, karya tersebut termasuk dalam metode tafsir ijmali, karena menjelaskan makna Alquran secara global. Terjemahan Alquran tersebut juga berkarakteristik kedaerahan dan sastra, karena mengungkapkan makna Alquran dengan bahasa daerah (Aceh) dengan bentuk sajak a-b-a-b dengan pendekatan kultur masyarakat Aceh.
Penafsiran Ibnu Katsir terhadap Ayat-Ayat Isra’ Mikraj
Authors: Mohd Asri Ahmad Asyraf Bin , Zainuddin Zainuddin
Published: April 2022

Faith means belief in the heart, words in the mouth and practice with the limbs. Every believer must believe in Allah, His angels, His books, His Messengers, the Last Day, and belief in both good and bad destiny. Believing in the miracles of the apostles includes believing in the apostles. Among the miracles of the Prophet SAW is the Isra 'Mikraj event. This event is clearly mentioned in QS. al-Isrā' (17): 1 and QS. al-Najm (53): 5-18. This incident is also found in the hadiths of various narrations. The commentators have described in depth this great event, among them is Ibn Kathir. In the theory of creed, the arguments and proofs related to the issue of faith must be with definite arguments (qath'i), and cannot use conjectures (dzan). However, Ibn Kathir uses the dha'īf hadith and the āhād hadith in his interpretation of Isra' Mikraj. The research method used by the author is library research, including secondary data collection and processing of the data that has been obtained using descriptive-analytical methods. The author collects data according to the findings, then analyzes the data and understands Ibn Kathir's thoughts on the verses related to Isra and Mikraj. Iman berarti keyakinan dalam hati, perkataan di lisan dan amalan dengan anggota badan. Setiap mukmin wajib beriman kepada Allah Swt, malaikat-malaikat-Nya, kitab-kitab-Nya, Rasul-Rasul-Nya, hari akhir, dan beriman kepada takdir baik maupun yang buruk. Mempercayai mukjizat-mukjizat para rasul termasuk beriman kepada rasul. Di antara mukjizat Nabi Saw adalah peristiwa Isra’ Mikraj. Peristiwa tersebut disebut secara jelas dalam QS. al-Isrā’ (17): 1 dan QS. al-Najm (53): 5-18. Peristiwa ini juga terdapat dalam hadis dari pelbagai riwayat. Para mufasir telah menguraikan dengan mendalam peristiwa besar ini, di antaranya adalah Ibnu Katsir. Dalam teori akidah, dalil dan hujjah yang berkaitan dengan masalah akidah haruslah dengan dalil yang pasti (qath‘i), tidak bisa menggunakan dugaan (dzan). Namun, Ibnu Katsir menggunakan hadis dha‘īf dan hadis āhād dalam penafsirannya tentang Isra’ Mikraj. Metode penelitian yang digunakan penulis adalah library research (penelitian kepustakaan), meliputi pengumpulan data sekunder dan mengolah data-data yang telah didapatkan dengan menggunakan metode deskriptif-analitis. Penulis menghimpun data sesuai hasil temuan, lalu melakukan analisis data tersebut dan memahami pemikiran Ibnu Katsir terhadap ayat-ayat yang berkaitan dengan Isra’ dan Mikraj.
Design and Evaluation of Mebeverine Hydrochloride Microspheres with Novel Timed Release Polymers
Authors: Kumar M Pradeep , Murthy G Suryanarayana , Sreekanth A , Ramana BV , Kiran. Badithala Siva Sai
Published: April 2022

Drugs having the shorter half life are needed to be administered frequently in order to maintain the required therapeutic concentrations. One of the strategies to overcome the frequent administration is by developing the controlled release formulations. Microspheres including the micro particles and microcapsules (having a core of the drug) of 1-1000 μm in diameter are one of the emerging controlled drug delivery systems that can eliminate the frequent drug administration. Hence, in the present study an effort was made to formulate microsphere of Mebeverine HCl by using different delayed-released polymers at different concentrations. Different formulations were prepared using guar gum and glutaraldehyde as delayed release polymers and evaluated for the properties like the effect of polymer concentrations on the microsphere formation, particle size, muco-adhesion etc. Also, the prepared microspheres were evaluated for flow properties along with the drug release rates. From the results, it was observed that higher concentrations of polymer resulted in better microsphere formation compared to low concentrations. Projection Microscopic images of optimized formulation showed that the microspheres have rough surface. In vitro drug release studies showed that the optimized formulation showed 96.26 percent Mebeverine HCl release at the end of 13 hours. Overall, it can be concluded that the preparation of Mebeverine HCl microspheres can eliminate the need for frequent administration thereby providing the better therapeutic compliance compared to the conventional dosage forms.
IMPROVEMENT OF THE MECHANISM OF EDUCATION EXPORT DEVELOPMENT IN THE RUSSIAN FEDERATION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Елена Юрьевна Золочевская , Яна Евгеньевна Сивакова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: April 2022

This article analyzes the current practice of exporting education in the Russian Federation, shows the characteristics of integration processes in higher educational institutions in the vector of export of educational services, developed a model for improving the mechanism for overcoming barriers in attracting foreign citizens to study in educational institutions of the Russian Federation, analyzed the economic, social - political and demographic approaches, the factors of negative phenomena in the processes of export of educational services are determined
TYPOLOGY OF ORGANIZATIONAL CULTURE IN THE CONTEXT OF ITS VALUE ORIENTATIONS
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Александр Васильевич Попов , Александр Васильевич Попов ,   Ростовский государственный экономический университет, Ростов-на-Дону, Анна Григорьевна Лугинина ,   Кубанский государственный аграрный университет имени И. Т. Трубилина, Краснодар, Россия
Published: April 2022

Within the framework of this article, the issue of management is considered, concerning the identification of types of organizational culture, which are based on the value orientations of the organization that regulate organizational rules, traditions and norms of behavior of personnel. Two levels of organizational culture are differentiated on the basis of the dichotomy "general – particular": the culture of the organization as a kind of general systemic whole, "superquality", consolidating the particular – the individual culture of the staff. The article analyzes well-known Western typologies of "organizational ideologies" (C. Handy), the framework of competing values (K. Cameron, R. Quinn), as well as the AGIL typology (T. Parsons). It is concluded that the value-content aspects of organizational culture are the priority object of management.
Spiking based Raman Model Calibration for Perfusion Cell Culture using a Harvest Library
Authors: Romann Patrick , Kolar Jakub , Tobler Daniela , Herwig Christoph , Bielser Jean-Marc , Villiger Thomas
Published: April 2022

Raman spectroscopy has gained popularity to monitor multiple process
indicators simultaneously in biopharmaceutical processes. However,
robust and specific model calibration remains a challenge due to
insufficient analyte variability to train the models and high
cross-correlation of various media components and artefacts throughout
the process. Therefore, a systematic Raman calibration workflow for
perfusion processes enabling highly specific and fast model calibration
was developed. A harvest library consisting of frozen harvest samples
from multiple CHO cell culture bioreactors collected at different
process times was established, capturing process variability as widely
as possible. Model calibration was subsequently performed in an offline
setup using a flow cell by spiking process harvest with various sugars
known to modulate glycosylation patterns of monoclonal antibodies. In a
screening phase, Raman spectroscopy was proven capable not only to
distinguish glucose, raffinose, galactose, mannose, and fructose in
perfusion harvest, but also to quantify them independently in process
relevant concentrations. In a second phase, a robust and highly specific
calibration model for simultaneous glucose (RMSEP = 0.32 g/L) and
raffinose (RMSEP = 0.17 g/L) real-time monitoring was generated and
verified in a third phase during a perfusion process. The proposed
offline calibration workflow allowed proper Raman peak decoupling,
reduced calibration time from months down to days and can potentially be
applied to other analytes of interest including lactate, ammonia, amino
acids, or product titer.
Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain
Authors: Tosif Shidan , Haycroft Ebene R. , Sarkar Sohinee , Toh Zheng Quan , Anh-ha Do Lien , Donato Celeste M. , Selva Kevin J. , Hoq Monsurul , Overmars Isabella , Nguyen Jill , Lee Lai-Yang , Clifford Vanessa , Daley Andrew , Mordant Francesa L. , McVernon Jodie , Mulholland Kim , Marcato Adrian , Smith Miranda , Curtis Nigel , McNab Sarah , Saffery Richard , Kedzierska Katherine , Subarrao Kanta , Burgner David , Steer Andrew , Bines Julie E. , Sutton Philip , Licciardi Paul , Chung Amy W. , Neeland Melanie , Crawford Nigel W.
Published: April 2022

Background Household studies are crucial for understanding the
transmission of SARS-CoV-2 infection, which may be underestimated from
PCR testing of respiratory samples alone. We aim to combine assessment
of household mitigation measures; nasopharyngeal, saliva and stool PCR
testing; along with mucosal and systemic SARS-CoV-2 specific antibodies,
to comprehensively characterise SARS-CoV-2 infection and transmission in
households. Methods Between March and September 2020, we
obtained samples from 92 participants in 26 households in Melbourne,
Australia, in a 4-week period following onset of infection with
ancestral SARS-CoV-2 variants. Results The secondary attack
rate was 36% (24/66) when using nasopharyngeal swab (NPS) PCR
positivity alone. However, when respiratory and non-respiratory samples
were combined with antibody responses in blood and saliva, the secondary
attack rate was 76% (50/66). SARS-CoV-2 viral load of the index case
and household isolation measures were key factors that determine
secondary transmission. In 27% (7/26) of households, all family members
tested positive by NPS for SARS-CoV-2 and were characterised by lower
respiratory Ct-values than low transmission families (Median 22.62 vs
32.91; IQR 17.06 to 28.67 vs 30.37 to 34.24). High transmission families
were associated with enhanced plasma antibody responses to multiple
SARS-CoV-2 antigens and the presence of neutralising antibodies. Three
distinguishing saliva SARS-CoV-2 antibody features were identified
according to age (IgA1 to Spike 1, IgA1 to nucleocapsid protein (NP),
suggesting that adults and children generate distinct mucosal antibody
responses during the acute phase of infection. Conclusion
Utilising respiratory and non-respiratory PCR testing, along with
measurement of SARS-CoV-2 specific local and systemic antibodies,
provides a more accurate assessment of infection within households and
highlights some of the immunological differences in response between
children and adults.
SPINAL MYOCLONUS DUE TO CERVICAL DISC HERNIATION: A CASE REPORT
Authors: Sidow Nor Osman , HASSAN MOHAMED SHEIKH
Published: April 2022

We present here a case of 35 year old male with spastic paraparesis for
two months associated with involuntary spontaneous abdominal
contractions, accompanied by involuntary jerks of his legs. MRI findings
pointed C3-C4 of disc herniation.
DERMATOFIBROSARCOMAPROTUBERANS (DFSP): A CASE REPORT OF A COMPLETE CURE
Authors: Pudasaini Prajwal , Paudel Sushil , Adhikari Sadiksha , Kafle Monique
Published: April 2022

DERMATOFIBROSARCOMAPROTUBERANS (DFSP) is a rare recurrent
fibrohistiocytic tumor. Given the limitation of available diagnostic
modalities in a resource poor setting, diagnosis can be confusing. As
most of the tumors recur with time, our case of complete cure was
interesting phenomenon observed in our case
Co-radiation of Leptospira and Tenrecidae (Afrotheria) on Madagascar
Authors: Gomard Yann , Goodman Steven M. , Soarimalala Voahangy , Turpin Magali , Lenclume Guenaëlle , Ah-Vane Marion , Golden Christopher D. , Tortosa Pablo
Published: April 2022

Leptospirosis is a bacterial zoonosis caused by pathogenic
Leptospira that are maintained in the kidney lumen of infected
animals acting as reservoirs and contaminating the environment via
infected urine. The investigation of leptospirosis through a One
Health framework has been stimulated by notable genetic diversity of
pathogenic Leptospira together with a high infection prevalence
in certain animal reservoirs. Studies of Madagascar’s native mammal
fauna have revealed a diversity of Leptospira with high levels of
host-specificity. Native rodents, tenrecids, and bats shelter several
distinct lineages and species of Leptospira, some of which have
also been detected in acute human cases. Specifically, Leptospira
mayottensis, first discovered in humans on Mayotte, an island
neighboring Madagascar, was subsequently identified in a few species of
Malagasy tenrecids, an endemic family of small mammals. Distinct
L. mayottensis lineages were identified in shrew tenrecs (
Microgale cowani and Nesogale dobsoni) on Madagascar, and
later in spiny tenrecs ( Tenrec ecaudatus) on Mayotte. These
findings suggest that L. mayottensis (i) has co-radiated with
tenrecids on Madagascar, and (ii) has recently emerged in human
populations on Mayotte following the introduction of T. ecaudatus
from Madagascar. Hitherto, L. mayottensis has not been detected
in spiny tenrecs on Madagascar. In the present study, we broaden the
investigation of Malagasy tenrecids and describe the presence of
L. mayottensis in Malagasy T. ecaudatus and M.
thomasi. These results confirm the hypothesis that L.
mayottensis was introduced to Mayotte, presumably via T.
ecaudatus, and provide additional data on the co-radiation of
Leptospira and Tenrecidae.
Computation of multiple binomial Series based on geometric series
Authors: Annamalai Chinnaraji
Published: April 2022

This paper presents addition of multiple binomial series based on
geometric series. In general, a finite multiple summations of a
geometric series are called binomial series. Addition of multiple
binomial series is a sum and summation of multiple binomial series.
Nutritional evolution and identification of factors associated with nutritional depletion in children and adolescents with malignant neoplasms submitted to radiotherapy
Authors: Guedes Karen Jaloretto Teixeira , Ferretti Roberta de Lucena , Petrilli Antonio Sérgio
Published: April 2022

Objective: To verify the evolution of the nutritional status (NS) of
children and adolescents with cancer during radiotherapy (RT) treatment
and to investigate which factors are associated with nutritional
depletion at the end of the treatment. Procedures: Historical cohort
with patients between 1 and 19 years, who underwent RT and received
nutritional monitoring throughout the treatment. Patients were evaluated
at T1 (up to 1 month before RT), T2 (2/3 months after starting RT) and
T3 (up to 1 month after RT completion). The evolution of weight,
mid-upper arm circumference [MUAC], triceps skinfold thickness
[TST], body mass index for age [BMI/A] and weight loss [WL]
were verified and considered severe when >5%. Results: A
reduction in BMI/A (p<0.001), weight (p 0.001), MUAC (p 0.001)
and TST (p 0.005), and an increase in the incidence of thinness (BMI/A
<-2) T1: 13.8% and T3: 19% and nutritional risk (BMI/A
between <-1 and >-2) - T1: 20.7% and T3: 27.6%
was observed in the general sample (n=116). Severe WL occurred in 40.7%
of the sample. Irradiation site (p<0.001), chemotherapy
[CT] (p 0.001) and CT and sedation (p 0.024) were associated with NS
of thinness at T3. However, irradiation site (p 0.006), CT (p 0.002) and
previous thinness (p 0.036) where observed for WL>5% (T1
and T3). Conclusions: The malnutrition process occurred in an expressive
and significant way, even in the presence of nutritional monitoring. The
irradiation site and concomitant chemotherapy were associated with
severe WL and thinness at the end of the treatment.
Baudrillard`s The Agony of Power
Authors: Ajvazi Irfan
Published: April 2022

For Baudrillard, absolute Evil today comes from an excess of Good, of
technologcial development, of totalitarian morality, of the desire to do
Good without opposition. The attempt to force the world into a
globalized and integrated society merely has the opposite effect of
generating an ideological “Axis of Evil” in the form of terrorism. But
there can be no axis of Evil, Baudrillard insists, because evil does not
have a direction; only Good–i.e. the global dominance of the free
market, etc.–can have a forward, linear direction.

Evil is more of a parallax, or a deviance, so it cannot even be opposed
to the Good. Only Good can have an axis, a direction, so the “axis of
evil” is something that is projected upon the Evil in order to justify
the Good as ideology. When you fight Evil militarily with a frontal
attack, you can only miss it.
Office Technology and Change Management amid Covid-19 Pandemic Study of Ikorodu Local Government, Lagos State, Nigeria
Authors:   1Department of Banking and Finance Department, 2,3Department of Office Technology &  Management Lagos State University of Science & Technology Ikorodu, Lagos, Nigeria, Abiola Lawal , Damisola Omolara Adewumi , Idiake Christiana O.
Published: April 2022

Office technology has not only improved the efficiency of office work but changes the nature of office work in general. Office Technology is the use of electronic devices to increase performance in workplace, the development of office systems raises several issues for the organization. Invention of modern Office systems have the potential to bring about profound changes in organization, this changes, if not well managed will affect the aims and objectives of the organization. This paper detailed and focused on The challenges in advancement in Office Technology and the changes involved in organization, how changes in technology are managed for efficiency in an organization, especially during the Covid-19 pandemic in Nigeria, using Ikorodu Local Government as a case study. The study used descriptive statistics which include tables, percentages, and graph. Questionnaires were used as the major research instruments. Three hundred (300 ) questionnaires were distributed among workers in Ikorodu Local Government and Two Hundred (200) were returned, hence, the study population. Two main research questions were formulated to guide the study, relevant Technology and change Management theories were used in this study. Data collected were presented in frequency tables and percentages, graphical representation were made to analyze. Discussions were made to each table and figure. It was deduced from this study that the pandemic era has led to advancement in technology in office system, hence, change is inevitable in office scenario. Based on the findings, this study recommended among other things that, Change in organization should be gradual and there should be training and retraining of office workers that involves in the use of sophisticated office equipment to be able to cope with changes technology bring in the workplace Keyword: Automation, Organization, Change, Management, Worker Journal Reference Format: Lawal, A., Damisola, O. Adewumi & Idiake, C.O. (2022): Office Technology and Change Management amid Covid-19 Pandemic Study of Ikorodu Local Government, Lagos State, Nigeria. Social Informatics, Business, Politics, L:aw, Environmental Sciences & Technology Journal. Vol. 8, No. 1 Pp 9-18 Article DOI No - dx.doi.org/10.22624/AIMS/SIJ/V8N1P2. www.isteams/socialinformaticsjournal
Implementation of the Carpathian convention in Serbia-the analysis of sustainability aspects
Authors: Pantic Marijana , Maricic Tamara , Milijic Sasa
Published: April 2022

One of the biggest and most important mountain ranges in Europe, the
Carpathians, is being threatened by different human activities. The
Framework Convention on the Protection and Sustainable Development of the
Carpathians (the Carpathian Convention) represents one of the international
efforts to protect the biodiversity of this area through multilateral
cooperation. Serbia is one of the signatory parties, where the area
protected by the Convention currently coincides with the Djerdap National
Park (DjNP) boundaries. Serbia mainly lags in protocol and amendment
ratifications, which is suspected to hinder the potential benefits regarding
the sustainable development of this region. By analyzing the selected
sustainability indicators for the years 2003, 2011, and 2019 we tried to
enlighten if developments were sustainable. The data were also presented by
the spider evaluation method. Despite certain limitations in data
availability, research showed that there are positive economic and
environmental changes, despite depopulation and aging of local inhabitants.
However, major efforts are still to be undertaken, especially regarding
environmental sustainability and implementation of national and
international regulation.
Self and Shame: A Gestalt Approach
Authors: WHEELER GORDON
Published: April 2022

Shame, both a universal human feeling and also one of the most potentially disorganizing of all affect experiences, has been relatively neglected in clinical writing until recent years and even today remains in unclear focus in much of our dominant clinical tradition and thinking about selfmodels. Both this neglect and this lack of focus are much clarified by a Gestalt model of self-experience and self-process—a perspective which raises paradigmatic questions for our thinking about human nature and relational process. Drawing on the tradition of affect theory and Goodman's radical revision of traditional self-theory, this article examines the terms of the underlying assumptions about self and relationship that have informed our traditional clinical models and offers a new model of shame, support, and their dynamic interplay in self-process and self-integration. Shame then emerges as a key signal affect in a field model of self, much as anxiety stood in this role in an older, individualist model. Implications for clinical practice are then considered, with an examination of five thematic clusters of possible therapeutic interventions, aimed at bringing shame issues to light in the therapeutic relationship itself, and offering the promise of transforming self-inhibition and disorganization into new self-development and growth.
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study
Authors: Liu Junxi , Richmond Rebecca C , Bowden Jack , Barry Ciarrah , Dashti Hassan S , Daghlas Iyas , Lane Jacqueline M , Jones Samuel E , Wood Andrew R , Frayling Timothy M , Wright Alison K , Carr Matthew J , Anderson Simon G , Emsley Richard , Ray David , Weedon Michael N , Saxena Richa , Lawlor Deborah A , Rutter Martin K
Published: April 2022

Objective: To examine the effects of sleep traits on glycated
haemoglobin (HbA1c).

Research Design and Methods: This study triangulated evidence across
multivariable regression (MVR), one-sample and two-sample Mendelian
randomization (1SMR and 2SMR) including sensitivity analyses on the effects of
5 self-reported sleep traits (i.e., insomnia symptoms (difficulty initiating or
maintaining sleep), sleep duration, daytime sleepiness, napping, chronotype) on
HbA1c (in standard deviation (SD) units) in adults of European ancestry from the
UK Biobank (for MVR and 1SMR analyses; n=336,999; mean (SD) age 57 (8) years, 54% female) and in the genome-wide association studies from
the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) (for
2SMR analysis;
n=46,368; 53 (11) years; 52% female).

Results: Across MV, 1SMR, 2SMR, and
their sensitivity analyses we
found a higher frequency of insomnia symptoms (usually vs sometimes or
rarely/never) was associated with higher HbA1c (MVR: 0.05 SD units, 95%
confidence interval (0.04 to 0.06), 1SMR: 0.52, (0.42 to 0.63), 2SMR: 0.24, (0.11
to 0.36)). Associations remained but point estimates were somewhat attenuated after
excluding participants with diabetes. For other sleep traits, there was less
consistency across, with some but not all, providing evidence of an effect.

Conclusions: Our results suggest that frequent
insomnia symptoms causes higher HbA1c levels and by implication, that insomnia
has a causal role in type 2 diabetes. These findings could have important
implications for developing and evaluating strategies that improve sleep habits
to reduce hyperglycaemia and prevent diabetes.
Acute Necrotizing Encephalitis - A Rare Entity
Authors: F Arshad
Published: April 2022

Acute necrotizing encephalitis is a disease characterized fever and infection associated with with rapid alteration of consciousness. Exact etiology remains unknown. Though the disease is nearly exclusively seen in East Asian countries but sporadic cases h ave been reported from all around the world. Neuroimaging shows symmetric lesions involving the thalami, brainstem, cerebellum, and white matter. Management is only supportive. This condition accompanies a poor prognosis with high morbidity and mortality rates. We report a case of 20 year old female who presented with presented with acute necrotising encephalitis.
Neuroprotective Effects of N - Acetyl - Methoxytryptamine in a Neurotoxic Mice Model of Huntington’s Disease Induced by Quinolinic Acid
Authors: RX Avilés - Reyes
Published: April 2022

Huntington’s Disease (HD) is an autosomal dominant neuropathology associated with severe degeneration in neurons of the basal ganglia. It is characterized by progressive motors symptoms, cognitive deficits and dementia. The genetic mutation induces trinucl eotide repeat expansion (TNR) of cytosine, adenine and guanine (CAG). The CAG - repeat is translated into a poly glutamine (polyQ) stretch caused by molding of DNA “loop out” structures and DNA slippage during the replication. This expanded sequence encodes a mutant huntingtin (mHtt), which is associated to neuronal dysfunction, cellular death, ubiquitous molecular and cellular anomalies. Furthermore, there are progressive impairments in motor control, cognitive function and mood. Quinolinic acid (QA) is an e xcitotoxic compound in humans and animals that has been linked to HD. N - acetyl - methoxytryptamine (MLT) is a hormone that produce anti - oxidant and anti - inflammatory effects on cell damage. The principal aim of this study is to know if QA induces damage in s triatal astrocytes and neurons and to evidence how MLT can participate as a neuroprotectant agent against the neurotoxic injury. We inoculate QA intrastriatal in 8 weeks old wild type (WT) female mice as endogenous neurotoxic model of HD. Here, we worked w ith three different groups of mice, and the striatal injection was administrated in all animals. PBS were inoculated in control mice; the second group was injected only QA; and the last group was pre - treated with MLT 30 min before the QA injection. Immunob lots, oxidative stress biomarkers, histological assay of astrocytes and neurons were evaluated as well as rotarod and open field tests. There was a reduction in proteins levels of BDNF and NeuN in QA mice. Contrary effects in lysates showed NF - κB, IκB α , HT T, GFAP and NRs. The analysis of CAT, SOD, Gpx and GSH showed decreased activity, while MDA displayed increased activation in QA mice. The animals pre - treated with MLT revers the tendency of proteins and antioxidant biomarkers; the HTT perinuclear staining in neurons was reduced. NeuN histochemistry showed a greater number of NeuN + cells; the astrogliosis was attenuated; and locomotor activities improved. Analysis of RT - PCR do no show significant diferences between teatments. This study suggests that MLT c an induce a compensatory response to neurotoxic stress againts neuro - glial injury. Thus, increasing MLT levels may be a promising treatment for HD disorder.
Short Term Hospital Outcome of Ischemic Stroke Patient Presenting with Hyponatremia
Authors: Saha Goutam
Published: April 2022

This observational prospective study was performed in the Department of Neurology and Medicine wards at Mymensingh Medical College Hospital, Bangladesh over the period of one year to assess the short term hospital outcome of ischemic stroke patients presenting with hyponatremia. Patients diagnosed as ischaemic stroke were primarily enrolled as study population in this study. Of them 50 patients were selected whose serum sodium was less than 135 meq/L as hyponatremic and another fifty patients were selected whose serum sodium was normal level (135-145) meq/L as normonatremic. The patients were followed up at admission and at the time of discharge. Disability was assessed by the mRS score. Mean age of hyponatremia patients and normonatremia patients were 64.8 ± 12.3 years and 60.9 ± 13.1 years respectively. Male were predominant in both groups. Mean Na+ level in hyponatremia patients was significantly lower than normonatremia patients (127.6 ± 5.7 mg/dl vs 139.3 ± 3.5 mg/dl). Even mortality rate was higher in hyponatremia group (12.0%) than that of normonatremia group (4.0%) the difference was not statistically significant (p>0.05). No significant difference was observed in disability rate between hyponatremia group and normonatremia group (81.8% vs 72.9%). The mean mRS scores at the time of admission (4.16 ± 1.03 vs 3.74 ± 0.75) and at the time of discharge (3.56 ± 1.21 vs 3.04 ± 0.98) were significantly higher in hyponatremia than normonatremia patients. This study result shows that mRS score is higher in hyponatremic stroke patients than that of normonatrimic stroke patients.
RELASI SOSIAL DALAM AL-QUR'AN
Authors: Amin Muhammad
Published: April 2022

Tulisan ini bertujuan menjelaskan tentang konsep al-Qur'an tentang relasi sosial. Relasi atau hubungan sosial merupakan salah satu tema yang sangat penting dalam al-Qur'an. Seorang muslim yang baik adalah yang mampu menjaga hubungan baik dengan sesama manusia (hablu min an-nas) dan hubungan baik dengan Tuhannya (hablu min Allah). Orang yang mampu berinteraksi dan menjaga hubungan baik dengan masyarakat adalah indikator dari hubungan baiknya dengan Tuhan. Sebaliknya orang yang bermasalah dalam hubungan sosial, menjadi indikator dari tidak baiknnya hubungan dengan Tuhan. Al-Qur'an memberikan sinyal yang jelas bahwa kesuksesan hidup manusia sangat tergantung kepada kemampuan dalam membina dua hubungan tersebut. Tulisan ini menggunakan metode tafsir tematik (maudu'i). Dalam menjelaskan ayat-ayat tentang relasi sosial, penulis merujuk kepada penafsiran para ulama dalam berbagai karya tafsir mereka. Ada beberapa prinsip utama relasi sosial dalam al-Qur'an, antara lain: menyambung tali silaturrahmi dan memperkuat persaudaraan (ukhuwah), saling tolong menolong (ta'awun), berani menegakkan kebenaran dan mencegah kejahatan (amar ma'ruf dan nahi munkar), bersikap klarifikatif (tabbayyun), berpikir positif (positive thinking) dan tidak mencari-cari kesalahan (tajassus), peduli kepada kaum yang lemah (du'afa), bermusyawarah (syura), memahami perbedaan (ta'uruf), dan toleransi (tasumuh) kepada nonmuslim.
Human Histology of a New Bulking Agent Containing PMMA-Microspheres for Gastric Reflux and Urinary or Fecal Incontinence
Authors: Lemperle, MD, PhD Gottfried
Published: April 2022

Background and study design: Bulking agents are currently not available for the treatment of gastroesophageal reflux disease (GERD) and only play a secondary role in the treatment of stress urinary incontinence (SUI) and fecal incontinence (FI). The main reasons for their reluctant use are a relatively high rate of reported adverse events with currently approved materials and competitive technologies. Microspheres made from polymethyl-methacrylate (PMMA) have been successfully injected as dermal fillers for 30 years. They produce a soft and pliable "living implant", do not dislocate, and meet all characteristics of an ‘ideal’ injectable bulking agent. Methods: To examine the histological responses to 125µm PMMA microspheres, 26 different blebs were injected subcutaneously into a human forearm and excised after 1 week, and 1, 6, and 12 months. Results: At 1 month, all spheres were engulfed by a large number of macrophages, which later merged into one giant cell embracing each individual microsphere. At 1 year, most macrophages and fibroblasts had left the implant, whose wide interspaces were filled with capillaries and collagen fibers. Monophasic highly cross-linked hyaluronic acid (HA) generates about 65% tissue. In comparison, biphasic HA, which does not keep the heavier PMMA microspheres in suspension, generates around 50% tissue, similar to the carrier material atelo-collagen (AC). Conclusions: PMMA microspheres produce a soft, fully vascularized “living implant”, which is resistant to erosion, migration, and dislocation. The most effective available carrier appears to be monophasic HA-gel, which keeps the beads apart and allows tissue in-growth at about 65% of the total implant volume.
PROGRAMMED LEARNING AS SOLUTION FOR SCHOOLS WITH COMBINED CURRICULUM TO WIN ENGLISH ONLINE NATIONAL EXAMINATION
Authors: Wibakti Ludwina Lucky
Published: April 2022

Programmed learning which consists of specially designed syllabus and CALL (Computer-Assisted Language Learning) was designed to win English Online National Examination at John Pauls School. It emerged as an answer to the employment of combined curriculum at Satuan Pendidikan Kerjasama School like John Pauls School where Cambridge curriculum is applied to prepare the students to take Cambridge International Examination as added value of the school and national curriculum which is provided at the final grade of each level, grade 9 and grade 12. The application of Online National Examination triggers the empowerment of information technology in formulating, designing, applying, evaluating and improving the Programmed Learning to its effectivity and efficiency. The success of the Programmed Learning application at John Pauls School may inspire other schools with combined curriculum to do similar things.DOI:https://doi.org/10.24071/ijiet.2018.020109
The influence of migration factor on the establishment of menstrual function in girls
Authors: Milushkina OYu , Popov VI , Skoblina NA , Bokareva NA , Astashkevich EV , Zakharova AA , Skoblina EV
Published: April 2022

The problems of migration are becoming increasingly important and have primary impact on women’s and children’s health. The aim of the study was to evaluate the influence of migration factor on the establishment of menstrual function in girls. The study enrolled 1,222 female undergraduate students of Moscow universities, born in 1995–2000, of diverse ethnicity. The data were collected in 2015–2020 by questionnaire method. The main group included 322 students classified as migrants and the comparison group included 900 students of local origin (Muscovites). Statistical processing of the data was carried out using Statistica 10.0 package (StatSoft; USA). Mean age at menarche constituted 151.35 ± 1.20 months in migrants and 150.88 ± 1.06 months in Muscovites (p > 0.05). For all participants, menarcheal age fell within the range of 11–15 years (normal). Other parameters of menstrual function were also similar between the groups and comparable to corresponding data collected in other countries.
Repenser un rythme favorable à la santé à l’ère de la pandémie de COVID-19
Authors: Moore Sarah A. , Vanderloo Leigh M. , Birken Catherine S. , Rehman Laurene A.
Published: April 2022

Est-ce que l’horaire auquel les enfants, les adolescents et les adultes sont actifs, demeurent sédentaires (par exemple devant un écran) et dorment ont une influence sur leur état de santé général? Ce numéro spécial de Promotion de la santé et prévention des maladies chroniques au Canada rassemble quatre articles qui présentent des données probantes et des recommandations concernant l’horaire des comportements en matière de mouvement : trois revues systématiques portant sur les associations entre les indicateurs de l’état de santé et les horaires d’activité physique, de sédentarité et de sommeil et un commentaire sur l’importance de ces données probantes pour les pratiques, les politiques et la recherche.
Cet éditorial prépare le terrain pour ce numéro spécial en décrivant les effets des restrictions de santé publique liées à la COVID-19 sur un rythme favorable à la santé. Maintenant semble un moment idéal pour réévaluer de quelle manière et selon quel horaire nous devrions être physiquement actifs, demeurer sédentaires et dormir pour favoriser notre santé.
Revue systématique des liens entre, d’une part, l’horaire des comportements sédentaires et l’accès à des activités sédentaires dans la chambre et, d’autre part, la qualité et la durée du sommeil chez les enfants et les adolescents
Authors: Saunders Travis J. , McIsaac Travis , Campbell Jenny , Douillette Kevin , Janssen Ian , Tomasone Jennifer R. , Ross-White Amanda , Prince Stephanie A. , Chaput Jean-Philippe
Published: April 2022

Introduction

L’objectif de cette étude était d’effectuer une revue systématique des relations entre, d’une part, l’horaire des comportements sédentaires et l’accès à des activités sédentaires dans la chambre et, d’autre part, la durée et la qualité du sommeil chez les enfants et les adolescents. Un objectif secondaire consistait à vérifier si ces relations étaient différentes selon le type d’activité sédentaire, c’est-à-dire selon si l’activité était liée à l’utilisation des écrans ou non.

Méthodologie

Nous avons cherché dans quatre bases de données les études ayant fait l’objet d’une évaluation par les pairs publiées entre le 1er janvier 2010 et le 19 janvier 2021. Le risque de biais pour chaque étude et le degré de certitude des données probantes ont été évalués en recourant à l’approche GRADE (Grading of Recommendations Assessment, Development and Evaluation).

Résultats

Nous avons trouvé 44 articles correspondant à nos critères de recherche, qui portaient sur des données issues de 42 bases de données et 239 267 participants. L’adoption de comportements sédentaires liés à l’utilisation des écrans le soir et l’accès à des écrans dans la chambre ont été associés à une baisse de la durée et de la qualité du sommeil. L’utilisation des écrans pendant la journée a aussi été associée à une baisse de la durée du sommeil, ce paramètre n’ayant cependant été pris en compte que dans relativement peu d’études. Qu’ils soient diurnes ou nocturnes, les comportements sédentaires non liés à l’utilisation des écrans n’ont pas été associables systématiquement à la durée ou à la qualité du sommeil. La qualité des données probantes a été évaluée comme étant faible à très faible pour tous les résultats.

Conclusion

Pour que la durée et la qualité du sommeil soient optimales, il faudrait nciter les enfants et les adolescents à réduire au minimum le temps passé devant les écrans le soir et bannir les écrans de leur chambre. (no d'enregistrement dans PROSPERO : CRD42020189082)
VISUEL - A Web Dynamic Dashboard for DataVisualization
Authors: Antonini Antonella Soledad , Ganuza María Luján , Castro Silvia Mabel
Published: April 2022

Data visualization aims to explore and analyze data quickly, interactively, and intuitively using visual representations. Faced with the constant growth of data in terms of volume and diversity, visualization techniques must confront the challenge of dealing with increasingly large datasets in terms of representation, interaction, and performance. Therefore, these techniques must be able to effectively convey the characteristics of the information space and inspire discovery.In this article, we present VISUEL, a web dynamic dashboard for data visualization. VISUEL supports multiple coordinated views, integrating visualization techniques such as scatter plots, parallel coordinates, and box plots, and interactive schematic maps to represent information enriched with spatial references.VISUEL is fully interactive, supporting traditional interactions like filtering, selection, brushing and linking, and zooming, among others. It also allows the user to configure the visual representation of their data, by selecting the color and shape of the representations.We illustrate the usefulness of this tool using real-life data related to the wine industry in Argentina. Important aspects of our case study are discovered through the construction and analysis of multiple views.
Introducción al dossier: Alfabetización en información: tendencias, conocimientos y experiencias innovadoras en bibliotecas y otros espacios educativos y culturales
Authors: Valenzuela Urra Cristian , Oliveros Castro Sergio , Valdenegro Egozcue Boris
Published: April 2022

Introducción al dossier: Alfabetización en información: tendencias, conocimientos y experiencias innovadoras en bibliotecas y otros espacios educativos y culturales
Competência Crítica em Informação e Educomunicação: proposta interdominial no combate à desinformação
Authors: Alencar Ana Paula , Ferreira Marques Juliana , Schneider Marco , Carvalho Alves Edvaldo
Published: April 2022

Hiperinformação, teoria da conspiração, algoritmos, notícias falsas, ciência falsa, falso profundo , pós-verdadeiro, cultura odium, sabemos que faz parte de um centro de informação atualizado que não diz respeito à desinformação, sem contexto e processo mediador da contemporaneidade . Em conjunto, várias esferas da sociedade são desafiadas a conduzir relações e processos contrários a essa realidade. Destacam-se, nessa missão, escolas, universidades e outros centros educativos, que têm um papel preponderante para o desenvolvimento do sentido crítico que norteia uma opinião pública marcada pelo compromisso comum com a ética, com liberdade de racionalidade, capaz de enfrentar a desinformação.Nesse sentido, são apresentados a uma realidade de desvalorização profissional, baixos salários e perda de abastecimento de embarcações, os professores cumprem um importante papel de mediadores ou de conhecimento das pessoas, capacitando ou fortalecendo a cidadania. A partir dessa realidade, diferentes áreas do conhecimento têm trazido contribuições que não fazem sentido para compreender esse potencial de enfrentar uma combinação de desinformação no ambiente escolar e acadêmico com a participação ativa de dois professores. Embora parecia discutir este fenômeno sob diferentes perspectivas, alguns domínios teóricos capazes de abordagens conceituais e epistemológicas complementares.Assim, é nosso objetivo com este estudo, e discutir as possibilidades de utilização de um construto interdominial entre Competição Crítica em Informação (CCI) e Educomunicação de ambito não educacional; Oferece uma sequência de atividades educacionais e de comunicação para a formação de professores.
El resto de las cosas
Authors: Lucentini Verónica
Published: April 2022

Este artículo propone analizar la instalación El dominio del mundo (2017), de la artista argentina Eugenia Calvo, en la cual se reconocen una serie de estrategias que operan transfigurando un universo cotidiano aparentemente estable. A través de la estructuración del espacio de la Sala de Exposiciones de la Universidad Torcuato Di Tella y la disposición negada de los objetos de uso doméstico que obstruye su función original, la autora interpela el vínculo que habitualmente mantenemos con las cosas y los espacios, en pos de la construcción de relatos ficcionales.