bluuebunny/crossref_metadata_2025 huggingface dataset:
Initial report of a clinical trial evaluating the safety and efficiency of neoadjuvant camrelizumab and apatinib in patients with recurrent high-grade gliomas
Authors: Lin Fuhua , Guo Chengcheng , Yang Qunying , Chen Yinsheng , Ke Chao , Sai Ke , Zhang Ji , Jiang Xiaobing , Hu Wanming , Xi Shaoyan , Zhou Jian , Li Depei , Zhou Zhihuan , Zhao Qinqin , Cao Xi , Chen Zhong-ping
Published: March 2022

Background

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and

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Aim:

High-grade glioma is the most common malignant primary brain tumor in the central nervous system. Multiple strategies such as surgery, radiotherapy, and chemotherapy have been used, but the prognosis of patients with high-grade glioma remains poor. No standard treatment exists for recurrent gliomas; however, combination therapies of programmed cell death protein 1 blockades with antiangiogenic agents have demonstrated promising effects in different solid tumors. Therefore, since the end of 2020, a clinical trial designed to evaluate the safety and efficiency of neoadjuvant therapy using camrelizumab and apatinib in patients with recurrent high-grade gliomas has been carried out in our institution.

Methods/Design:

In this prospective, Phase II, single-arm study, patients with recurrent high-grade gliomas will receive single-dose intravenous injection of camrelizumab (200 mg) and daily oral administration of apatinib (250 mg/day for 7 days) 14 days before reoperation for tumor resection. Sequential therapy will begin 2 weeks after surgery with the biweekly injection of camrelizumab and 4 weeks after surgery with the daily administration of apatinib. Treatment of camrelizumab and apatinib will be continued until disease progression or unacceptable toxicity or death. The primary outcome measure will be the median overall survival rate. Secondary outcome measures will include progression-free survival rate at 6 months and at 12 months and other measures. The trial is planned to enroll 30 patients. This study was approved by the Ethics Committee of Sun Yat-sen University Cancer Center (Guangzhou, China; approval No. SL-B2020-149-01) on July 27, 2020.

Results

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and

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Conclusions:

Although an evaluation is still impossible to be conducted yet, 11 patients had been enrolled by the end of January 2022. Some patients have shown a promising outcome. These preliminary data suggest that this study would be worthwhile. We hope that this study will provide scientific evidence to better care of patients with recurrent high-grade glioma.

Trial

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registration:

This study was registered with ClinicalTrials.gov under identifier NCT04588987 on October 19, 2020.
Improvement of the Nurses' Awareness toward Ventilator-Associated Pneumonia Based on Evidence Guidelines
Authors: ALaswad Zainab Mohamed , Bayoumi Magda
Published: March 2022

Background:

Ventilator Associated Pneumonia (VAP) is a common hospital acquired infection that occurs as complication in patients who are connected to Mechanical Ventilation (MV). Nurses in intensive care unit (ICU) should be updated with the latest evidence-based practice to prevent such complication. This study aimed to assess improvement of the nurses' awareness toward ventilator-associated pneumonia based on latest evidence guidelines.

Methods:

A quantitative pretest-posttest design has been conducted. Using a convenience sample of 58 nurses who are working in the ICU were recruited. Tools: A self-administrative questionnaire was adapted to assess the nurse's knowledge about VAP and VAP prevention bundle.

Results:

The results highlighted that all ICU nurses had improvement of knowledge level pre-post regarding VAP (p <0.001), VAP prevention (p <0.001), and the overall knowledge score improvement revealed significantly higher after the educational program (p <0.001).

Conclusion:

Periodic refreshing on-services education program should be provided to nurses in ICU to improve their knowledge and to maintain high level of information, moreover hospital policies should include updated guidelines for VAP prevention bundle and protocol from international evidence.
Lipid Accumulation Product Better Predicts Metabolic Status in Lean Polycystic Ovary Syndrome than that by Visceral Adiposity Index
Authors: Banu Hurjahan , Morshed Md. Shahed , Sultana Tania , Shah Sukanti , Afrine Shazia , Hasanat M. A.
Published: March 2022

Background:

Both visceral adiposity index (VAI) and lipid accumulation product (LAP) can be used to assess insulin resistance (IR) and metabolic syndrome (MetS) which are required for management of even lean polycystic ovary syndrome (PCOS) (body mass index [BMI] <23 kg/m2).

Aim:

This study was aimed to see the magnitude of associations of VAI and LAP with cardiometabolic risk factors including IR and MetS in lean PCOS.

Study Setting and Design:

This cross-sectional study was done amongst 62 newly detected lean PCOS patients and 58 age- and BMI-matched healthy controls.

Materials and Methods:

PCOS was diagnosed according to the Revised 2003 Rotterdam Consensus criteria. Along with relevant clinical data, fasting blood was taken to measure glucose, insulin and lipid profile by glucose oxidase, chemiluminescent microparticle immunoassay and by glycerol phosphate dehydrogenase-peroxidase method, respectively. IR was calculated by homeostasis model of IR (HOMA-IR). VAI and LAP were calculated from BMI, waist circumference, triglyceride and high-density lipoprotein cholesterol by using sex-specific formulae.

Statistical Analysis Used:

Linear and binary regression analyses and receiver operating characteristics curve (ROC) analyses were done as appropriate.

Results:

Only LAP had predictive associations with age, systolic and diastolic blood pressure and total and low-density lipoprotein cholesterol. Both VAI and LAP had predictive associations with history of subfertility and MetS. LAP had moderate discriminating index for IR with cut-off of HOMA-IR of 2.3. Both VAI and LAP had excellent discriminating index for MetS in lean PCOS patients.

Conclusions:

LAP had more associations with cardiometabolic risks than VAI and was a moderate discriminator of IR in lean PCOS.
Prevalence of Polycystic Ovarian Syndrome, Phenotypes and their Ovulation Response to Sequential Letrozole Dose Escalation among Infertile Women at a Tertiary Care Centre in Southern India
Authors: Khurana Abha , Swamy M. V. , Mitra Sujoy , Srinivas Sangisapu , Nagaraja N.
Published: March 2022

Background:

Women with polycystic ovarian syndrome (PCOS) often have anovulatory infertility requiring ovulation induction with letrozole.

Aims:

This study aimed to determine the prevalence and phenotypic categorisation of infertile PCOS women and to assess ovulatory response and pregnancy rates of PCOS phenotypes with sequential letrozole dose escalation.

Study Setting and Design:

This was a prospective observational study.

Materials and Methods:

One hundred seventy-five infertile PCOS women were enrolled. One hundred fifty-six women received ovulation induction as per the protocol with sequential letrozole dose escalation in each subsequent cycle (2.5 mg, 5 mg and 7.5 mg). Responses were assessed by ovulation and/or pregnancy.

Statistical Analysis Used:

Descriptive statistics were elaborated by means, medians, frequencies and percentages. Group comparisons and linear correlation between two continuous variables were done using appropriate statistical tests.

Results:

Eighty-seven (49.7%) women were Phenotype A; 11 (6.3%) were Phenotype B; 20 (11.4%) were Phenotype C and 57 (32.6%) were Phenotype D in our study. After excluding the lost to follow up participants in each induction cycle, 33.3% (2.5 mg dose); 62.8% (5 mg dose) and 78.9% (7.5 mg dose) women responded to letrozole. A significant increase in ovulation to escalating letrozole doses was noted (Phenotype A: 35.1% to 2.5 mg, 53.7% to 5 mg and 72.7% to 7.5 mg; Phenotype B: 30% to 2.5 mg and 80% to 5 mg; Phenotype C: 35.3% to 2.5 mg and 87.5% to 5 mg and Phenotype D: 30.8% to 2.5 mg, 65.6% to 5 mg and 87.5% to 7.5 mg). Fifty-six of 156 (35.9%) infertile PCOS women achieved pregnancy; increase in pregnancy rates with escalated doses of letrozole was noted.

Conclusion:

All PCOS phenotypes show a similar response to escalating doses of letrozole. The role of phenotypic sub-categorisation for variable response to letrozole as an ovulation-inducing agent is uncertain.
Role of Female Age in Regulating the Effect of Sperm DNA Fragmentation on the Live Birth Rates in Intracytoplasmic Sperm Injection Cycles with Own and Donor Oocytes
Authors: Repalle Deepthi , Saritha K. V. , Bhandari Shilpa , Chittora Megha , Choudhary Jitendra
Published: March 2022

Background:

Sperm DNA integrity assessment has been progressively used as an unfettered measure of sperm as it proffers more prognostic and diagnostic information than routine semen analysis. The contentious effect of sperm DNA fragmentation (SDF) on clinical outcomes can be attributed to female factors such as age, oocyte quality and ovarian reserve.

Aims:

The study is mainly aimed to know the influence of SDF on the live birth rates in intracytoplasmic sperm injection (ICSI) cycles with own and donor oocytes. Second, to know the role of female age in regulating the effect of SDF on the live birth rates in ICSI cycles with own and donor oocytes.

Setting and Design:

A prospective cohort study was done at our tertiary care centre attached to the reproductive medicine unit in medical college.

Materials and Methods:

The study included 356 patients who underwent first ICSI cycles either with own or donor-oocytes along with day 5 fresh embryo transfers only. The main outcome measures were live birth rates and miscarriage rates.

Statistical Analysis Used:

Chi-squared test was used to compare the categorical variables between the groups. The receiver operating characteristic curve was developed to correlate the female age with the live birth rate.

Results:

A significant decrease in the live birth rates (42.85% vs. 26.15%, P = 0.023) and an increase in the miscarriage rates (12.30% vs. 34.61%, P = 0.013) were observed in the high-SDF group ICSI cycles of own-oocyte patients. However, there was no significant difference in the live birth rates and miscarriage rates in the low- and high-SDF groups of donor oocyte ICSI cycle patients (P > 0.05). The own-oocyte ICSI cycle patients were further stratified based on the female age. In the female age group ≤30 years there was no significant difference in the live birth and miscarriage rates (P > 0.05) similar to donor oocyte ICSI cycles. Whereas, there was a significant difference in the live birth rates in the females of age >30 years (13.79% vs. 34.37%, P = 0.040).

Conclusion:

In conclusion, high-SDF has a negative influence on the live birth rates and a positive influence on the miscarriage rates in patients with own-oocyte ICSI cycles. A similar influence was not observed in patients with donor-oocyte ICSI cycles and in young female patients (age ≤30 years) with own-oocyte ICSI cycles.
The İmpact of Gonadotropin Type on Controlled Ovarian Stimulation and İntrauterine İnsemination Cycle Outcomes
Authors: Cicek Ozge Senem Yucel , Demir Merve
Published: March 2022

Background:

Intrauterine insemination (IUI) combined with controlled ovarian stimulation (COS) results in higher pregnancy rates. However, there is still no consensus on the optimal COS protocol.

Aims:

In the present study, we aimed to analyse the effects of COS protocols with different gonadotropin types on IUI outcomes.

Study Setting and Design:

This was a retrospective cohort study conducted at the infertility clinic of a University hospital, including 237 COS + IUI cycles.

Materials and Methods:

Eligible cycles were divided into three groups according to the type of gonadotropin used for COS; cycles with recombinant follicle-stimulating hormone (rFSH) (group 1, n = 36), highly purified FSH (HP-FSH) (group 2, n = 178) and highly purified menotropin (HP-hMG) (group 3, n = 23). Clinical pregnancy rate (CPR) and live birth rate (LBR) per cycle were compared between groups.

Statistical Analysis Used:

The Mann–Whitney U test and Kruskal–Wallis test were used to compare numerical variables. Dunn test was used for multiple comparisons.

Results:

The duration of stimulation and total gonadotropin dose were similar between the three groups (P > 0.05). The CPR was 16.7% in rFSH group, 9.6% in HP-FSH group and 13.0% in HP-hMG group. The LBR was 16.7% in rFSH group, 8.4% in HP-FSH group and 13.0% in HP-hMG group. Both CPR and LBR were comparable in all three groups (P > 0.05).

Conclusions:

Ovarian stimulation with rFSH, HP-FSH and HP-hMG show similar COS characteristics. Furthermore, these three gonadotropin protocols for COS + IUI yielded comparable CPR and LBR. These findings suggest that all three gonadotropin types (rFSH, HP-FSH, HP-hMG) are similarly effective in COS + IUI cycles.
Transvaginal Ultrasound-Guided Methotrexate Instillation for Failed Medical Management of Ectopic Pregnancies in Subfertile Women
Authors: Naredi Nikita , Tripathy Sumeet Ranjan , Sharma Rajesh
Published: March 2022

Background:

Ectopic pregnancy (EP) defined as extrauterine implantation of the embryo can be managed medically or surgically. Medical management entails systemic administration of the antineoplastic drug methotrexate (MTX) which, if not successful, surgical management is resorted to. However, we carried out this study wherein the failed medical management cases were given intra-gestational sac MTX instead of surgery.

Aim:

The aim of this study was to assess the efficacy of intra-gestational MTX administration as a treatment modality for failed medical management of ectopic pregnancies.

Study Setting and Design:

It was a prospective interventional study carried out at the Reproductive Medicine Centre of a tertiary care hospital.

Materials and Methods:

It was a prospective interventional study wherein 12 patients of EP with failed medical management (as per established criteria) were administered intra-gestational MTX with follicle aspiration needle under transvaginal sonography guidance.

Statistical Analysis Used:

Data were collected in Microsoft Excel. Numerical continuous variables were expressed as mean ± standard deviation. Categorical variables were expressed as count/percentage.

Results:

All the patients responded to the local administration of MTX, with none requiring rescue surgery. In addition, no one had any complication of the local instillation. However, one patient required an additional dose of MTX.

Conclusion:

Intra-gestational MTX administration is a viable non-surgical modality for treatment of ectopic pregnancies even in cases of failed medical management with an added benefit of tubal preservation.
COVID-19 pneumonia in children admitted in a tertiary care hospital of West Bengal
Authors: Singh Rajesh Kumar , Simalti Ashish Kumar , Bera Parichaya , Saha Manali
Published: March 2022

Severe acute respiratory syndrome coronavirus 2 created a pandemic across the world leading to several affected cases and deaths. The current case series focuses on clinical characteristics of COVID pneumonia in eight children during the second wave. Cases with respiratory symptoms and high-resolution computed tomography findings suggestive of COVID pneumonia were included. Five had moderate-to-severe symptoms and three had mild symptoms. All the severe/moderately severe cases were obese. Two cases with moderate-to-severe disease and two cases with mild disease had comorbidities. All the children recovered and were discharged. C-reactive protein (CRP) levels were higher in accordance with severity of disease. Some cases had fatigue, weakness, acne, hypertension, intermittent fever in postdischarge period. We conclude that pediatric COVID pneumonia mostly affected obese teenagers and responded well to treatment; however, regular follow-up is essential for post-COVID complications.
Complete traumatic transection of thoracic spinal cord in a pediatric patient
Authors: Garg Rachit , Sarangi Bhakti U , Shankar Guruprasad Hassan , Walimbe Ajay
Published: March 2022

With pediatric spinal cord injuries themselves being an infrequent event worldwide, complete transection of the spinal cord forms an extremely small subset of the same. Moreover, complete transection of spinal cord without the concurrent presence of vertebral compression fractures has rarely been reported in the pediatric age group. We hereby present a pediatric case with traumatic brain injury as well as complete thoracic spinal cord transection and probe the possible mechanisms that contribute to these injuries in the pediatric age group. We also discuss the challenges faced in the diagnostic evaluation as well as the therapeutic dilemmas in the given scenario due to the multiple ongoing issues.
Holonomy invariants of links and nonabelian Reidemeister torsion
Authors: McPhail-Snyder Calvin
Published: March 2022

We show that the reduced

\operatorname{SL}_2(\mathbb{C})

-twisted Burau representation can be obtained from the quantum group

\mathcal{U}_q(\mathfrak{sl}_2)

for

q = i

a fourth root of unity and that representations of

\mathcal{U}_q(\mathfrak{sl}_2)

satisfy a type of Schur–Weyl duality with the Burau representation. As a consequence, the

\operatorname{SL}_2(\mathbb{C})

-twisted Reidemeister torsion of links can be obtained as a quantum invariant. Our construction is closely related to the quantum holonomy invariant of Blanchet–Geer–Patureau-Mirand–Reshetikhin, and we interpret their invariant as a twisted Conway potential.
EVs on Road Ground-Impact Energy Evaluation Methodology: Dynamic of a Finite Element (FE)-Based Battery Pack Integrated into Full Vehicle Multi-Body Model on Abaqus
Authors: Zito Massimiliano , Puleo Vincenzo , Signorini Alberto , DUNI Efthimio
Published: March 2022

The present paper documents a comprehensive study on the ground-impact of battery packs in Electric Vehicles (EVs), a paramount concern for vehicle manufacturers. During an accidental crash, battery packs are usually exposed dangerously to possible intrusion of foreign objects (e.g., road debris). With the purpose of developing a generic methodology to evaluate the released energy content and due to high nonlinearities involved during the ground-impact maneuvers, a hybrid full vehicle model is needed. Hence, both FE-based battery case and virtual energy sensors have been integrated into the current Abaqus multi-body (MB) full vehicle model (suspensions, steering system, engine and a trimmed body). Energy peaks are estimated simulating a vehicle going over obstacles that a typical customer can encounter in daily-life (no off-normal situations) performed at different approaching speeds and obstacle sizes.

To evaluate the energy, the battery plate is divided as if it were a spaced grid of identical square-sized modules. Plate surface modularization is useful to install properly a certain amount of virtual sensors that store and measure the energy released during the impact. In addition, this strategic layout promotes the accuracy of the contact conditions between obstacles and the battery case.

The concept underlying the proposed multidisciplinary sequential procedure, based on three different phases (on road-impact energy evaluation, load cases definition and battery case/mechanical structure strength), ensures both to define specification for subsequent analyses (making iterations on the structure faster) and to possibly complete an effective design validation of the specific vehicle project under test. This methodology has been successfully applied transversally to several vehicle architectures (e.g., light commercial vehicles, sport/compact utility vehicles, supercars) and it shows the benefits of choosing the integration strategy over a typical co-simulation approach.
ON THE PROPAGATION OF EQUATORIAL WAVES INTERACTING WITH A NON-UNIFORM CURRENT
Authors: Novruzov Emil
Published: March 2022

We consider the propagation of equatorial waves of small amplitude, in a flow with an underlying non-uniform current. Without making the too restrictive rigid-lid approximation, by exploiting the available Hamiltonian structure of the problem, we derive the dispersion relation for the propagation of coupled long-waves: a surface wave and an internal wave. Also, we investigate the above-mentioned model of wave-current interactions in the general case with arbitrary vorticities.
Pandemi Döneminde Üniversite Öğrencilerinde Fiziksel Aktivite Düzeyi Değişiminin İncelenmesi: Kesitsel Bir Çalışma
Authors: YILDIZ KIZKIN Zeynep , AMIR RASHEDI BONAB Masoud , ÜSTÜN Kağan , ARMAĞAN Mehmet , HASIRCI Yusuf , KURU ÇOLAK Tuğba
Published: March 2022

Amaç: Sağlıklı üniversite öğrencilerinde fiziksel aktivite düzeyinin demografik özellikler ile ilişkisini incelemek ve pandemi öncesi ve sonrası değerleri karşılaştırmaktır.
Gereç ve Yöntem: Kesitsel tipte tasarlanan çalışmaya kronik hastalığı ve travmatik kas iskelet sistemi problemi bulunmayan 226 üniversite öğrencisi dahil edilmiştir. Katılımcıların demografik özellikleri ve fiziksel aktivite düzeyleri çevrimiçi oluşturulan bir anket yoluyla değerlendirilmiştir. Fiziksel aktivite düzeyi pandemi süreci ve öncesi göz önünde bulundurularak Uluslararası Fiziksel Aktivite Anketi Kısa Formu ile iki kez değerlendirilmiştir. Verilerin değerlendirilmesinde SPSS v24, Jamovi v1.8.2 ve örneklem büyüklüğünün belirlenmesinde G*power v3.1.9.6 programları kullanılmıştır. Veri analizleri bağımsız örneklem t-testi, Mann Whitney U testi, Wilcoxon sıralı işaretler testi ve Kruskal-Wallis testi analizlerinden ve mediasyon modellemesi kullanılarak gerçekleştirilmiştir.
Bulgular: Çalışmaya katılan öğrencilerin %5.8’i inaktif; %81.9’u orta düzeyde aktif; %12.4’ü ise aktifti. Pandemi döneminde şiddetli ve orta fiziksel aktivite, yürüme aktivite değerleri pandemi öncesine göre düşüş, oturma aktivitesi değerleri ise yükseliş gösterdi (p=0.037; p=0.033; p<0.001; p<0.001). Fiziksel aktivite değişimi değerleri cinsiyet ve yaşam çevresi gruplarına göre kıyaslandığında, gruplar benzerdi (p=0.086; p=0.157).
Sonuç: Pandemi döneminde fiziksel aktivite düzeylerinde düşüş gözlenmiştir. Özellikle online eğitim nedeniyle uzun süreler hareketsiz kalan genç bireylerde aktivite kısıtlılığı sonucu ortaya çıkabilecek sorunları önlemek için fiziksel aktivite teşvik edilmelidir.
Yükselen Piyasa Ekonomilerinde Finansal Gelişme ve Gelir Eşitsizliği İlişkisi: Yatay Kesit Bağımlılığı Altında Kurumların Moderatör Etkisi Üzerine Heterojen Panel Veri Analizi
Authors: ÜNLÜ Fatma
Published: March 2022

Bu çalışma, yükselen piyasa ekonomileri için finansal gelişme ve gelir eşitsizliği arasındaki ilişkide kurumların moderatör etkisini araştırmayı amaçlamaktadır. Söz konusu ülkelerin 2002-2018 dönemine ait verileri kullanılarak yatay kesit bağımlılığı altında heterojen panel veri analizine ilişkin prosedür takip edilmiştir. CCEMG tahmincisi kullanılarak yapılan analizlerden elde edilen bulgulara göre, uzun dönemde kaliteli kurumların gelir eşitsizliği üzerindeki etkisi pozitif iken, moderatör değişkenin etkisi ise negatiftir. Diğer taraftan, finansal gelişmenin gelir eşitsizliği üzerinde anlamlı bir etkisi bulunmamaktadır. Bu bulgular, finansal gelişmenin sadece kaliteli kurumların varlığı altında gelir eşitsizliğini azaltıcı etkilere sahip olduğunu göstermektedir. Bununla birlikte, Dumitrescu-Hurlin panel nedensellik test sonuçları da analize dahil edilen tüm değişkenler (finansal gelişme, gelir eşitsizliği, yolsuzluk ve moderatör değişken) arasındaki çift yönlü nedensellik ilişkilerini doğrulamaktadır.
Flourishing Ecommerce in India and around the Globe
Authors: Shelke Priya , Mirajkar Riddhi , Dedgaonkar Suruchi
Published: March 2022

In today's business, e-commerce is exploding. The term "e-commerce" refers to online transactions. Electronic commerce (e-commerce) is the buying and selling of products and services over the Internet, as well as the transmission of transactions and analytics. E-commerce is a paradigm change that affects marketers as well as customers. On the other hand, e-commerce is more than a new way to expand current business operations. It's heralding a sea change in business practises. This enormous shift in business paradigms is driving tremendous growth across the globe, especially in India. E-commerce has grown in popularity as a result of widespread internet use, and start-ups, especially, are progressively leveraging it as a distinctive business strategy. A big environmental impact can be observed because of Ecommerce. Despite the fact that the concept is frequently employed in current business contexts, it has yet to be fully investigated. The purpose of this study is to describe the current state of E-Commerce. The article covers a global perspective on E commerce and shows the top countries in terms of retail E commerce revenue growth in 2022. COVID-19 has a significant impact on global ecommerce trends. In this article, the top seven trends are summarized. The study goes on to look at the key variables that are essential for the achievement of E-commerce business prototypes. The challenges and opportunities related to E-commerce are also discussed.
An Economic Analysis of Soil Conservation in Meghalaya
Authors: Tyngkan Hehlangki
Published: March 2022

Soil is the most essential input in agriculture, while eroded land suffers from depletion of nutrients such as nitrogen, phosphorus and potassium, organic and moisture content of the soil, and reduction in cultivable soil depth. This study assesses the economics of erosion control technologies. The study was conducted in Meghalaya, based on a survey of 120 adopters and 120 non-adopters’ farmers from East Khasi hills and Ri-Bhoi districts. The common soil conservation technologies adopted by the farmers were bench terracing, contour bunding, peripheral bunding, loose boulder bunding and check dam. Among the conservation techniques, bench terracing was adopted in majority (34.17 per cent). For estimating the economics of these conservation techniques, four principal measures viz.,
Sistema Integral de pacientes con enfermedades transmitidas por vector
Authors: León Sosa Sandra Elizabeth , Báez Irma Yazmín Hernández , Ruiz Jaimes Miguel Ángel , Nieto Yañez Alma Delia , López Díaz Roberto Enrique
Published: March 2022

Las enfermedades transmitidas por vector, como el paludismo, el dengue, zika, chikungunya y chagas por mencionar algunas, representan más del 17% de todas las enfermedades infecciosas provocando defunciones. Las tecnologías de la información y las comunicaciones se han convertido en una herramienta de apoyo en el sistema del sector salud, brindando el soporte para enfrentarse a nuevos entornos de sistemas para el personal médico. Por lo tanto, el presente artículo hace mención al sistema integral para el proceso de registro de pacientes con enfermedades transmitidas por vector, permitiendo almacenar datos personales del paciente, información utilizada para enviar a realizar análisis mediante una orden de laboratorio, al tener el resultado el médico pueda dictaminar el diagnóstico, y proceder a registrar los resultados en el sistema integral, en caso de existir la necesidad de citar al paciente antes de la fecha para la cita, se envía el diagnóstico por correo electrónico notificando que debe presentarse a la brevedad posible. El sistema integral tiene como finalidad servir como una herramienta tecnológica para el personal médico permitiendo que la información quede registrada en el historial clínico del paciente.
Organochlorine Pesticide Quantification of Otogor Wetland Ughelli Delta for Secondary Schools Cage Aquaculture for Hunger Eradication in Nigeria
Authors:   Department of Vocational Education Agriculture Unit, Delta State University Abraka, Nigeria, C., Ph.D Ogwu
Published: March 2022

United Nations Sustainable Development Goal 2 requires all member Nations to achieve zero hunger by 2030. Agriculture especially aquaculture adopting cage technique has been recognised as a very viable option in achieving this set goal. Aquaculture requires water devoid of pollutants and that underscores the study. This is an ex-post facto research that answered 3 research questions and tested a hypothesis and its focus is on the determination of the organochlorine pesticides content of Otogor wetland for cage aquaculture in secondary schools for zero hunger. To achieve this, Otogor wetland was mapped out into research cells A, B, C, D, E. From each of the cells, water was sampled with clean sampling bottle tied to a graduated string from 5 spots at 10 cm depth. The water samples from each cell were then bulked, a composite drawn, fixed with HNO3 and stored in ice cooled box for analysis. The analytical standards adopted were USEPA 3570, APHA, Steindwandter and Shufter 1978. The analytical instrument deployed for determination is Agilent 6100 series single quadrupole LC/MS. The mean results of the organochlorine pesticides investigated in Otogor wetland were DDT 1.27±0.21μg/l, heptachlor 3.01±0.45μg/l, a-lindane 0.33±0.09μg/l, adrin 3.52±1.00 μg/l and endrin 0.32±0.11μg/l. The results of the organochlorine pesticides investigated were subjected to test of significance with ANOVA with numerator 4 and denominator 20. The F ratio calculated value is 5.59 while F ratio critical value is 2.87, thus rejecting Ho and accepting Ha. The study thus recommend that cage aquaculture should not be deployed in Otogor wetland with the present pollution status. The pollutants source point should be identified and discontinued and remediation should be commissioned in Otogor wetland to return the wetland to its healthy state to allow for the deployment of cage aquaculture for youths empowerment for zero hunger in Nigeria.
A Cross Sectional Study on Choice of Psychology as a Profession amongst Medical and Dental Graduates
Authors:   Latin American School of Medicine, Havana, Cuba, Ali Shazam
Published: March 2022

Introduction: Mental health is an ignored subject in the field of medicine and in the area of public health, and less 1% health budget is spent on mental health problems in developing countries. Aims and objectives: The basic aim of the study is to analyse the choice of psychiatry as a profession amongst medical graduates in Pakistan. Material and methods: This cross sectional study was conducted in Sharif Medical and Dental College, Lahore during 2019 to 2020. The data was collected through systematically designed questionnaire which include all the demographic data and history of selected participants. We also included additional scales to measure personality and stigma towards mental illnesses. The data was collected from 3rd year, 4th year, final year medical students and from house officers. Results: The data was collected from 700 students and house officers. There were 450 males and 250 female participants. However a significantly higher proportion of participants (22%, n=197) were reporting their interest in the field of Psychiatry who had done more than a month long psychiatry ward rotation as compare to those participants (14%, n=54) with less than a month rotations (P-value=0.01). Conclusion: It is concluded that current age of understudies have a more noteworthy attention to the potential for recuperation from serious mental sickness, so the animating openness to intense work is more compelling.
Mathematical Modeling and Optimal Control Strategies for Reducing the Spread of the Tuberculosis Infection
Authors:   Departementof  Mathematics,  Faculty  of  Science  and  Mathematics,  Diponegoro  University,  Jl.  Prof.  Soedarto  SH, Semarang 50275, Central Java, Indonesia, Qomariyah Nur
Published: March 2022

Tuberculosis is an infectious disease with transmission through the air and droplets of infected people. The problem of spreading and treating tuberculosis needs some development. The model used in this study is a model of development, in which infected individuals are divided into two subpopulations, namely the active infection subpopulation stage one and second stage infection is MDR (multi drug resistant). Four optimal control strategies are implemented with the aim of reducing the rate of spread of tuberculosis TB infection, prevention by increasing a clean and healthy lifestyle, and using masks when interacting between infected and susceptible, vaccination for family and close friends of infected individuals, implementing the DOTS strategy (Directly Observed Treatment Shortcourse) for infected individuals, and Intensive care in hospital. Then the optimal control of the model was analyzed using Pontriagin's Maximum Principle while for global stability using Lyapunov. The numerical results are obtained that the optimal control strategy given can accelerate in reducing the rate of spread of tuberculosis in Indonesia. this is evidenced by the graph of the population infected with tuberculosis every year after the control has decreased the number of infected, and the graph is heading to the equilibrium point.
Consenso de inmunizaciones en adultos con enfermedades reumáticas inflamatorias crónicas autoinmunes
Authors: Bonvehí Pablo , Cosentino Vanesa , Jordán Rosana , Larroude María Silvia , Nacinovich Francisco , Roccia Rossi Inés , Schneeberger Emilce , Stecher Daniel , Valledor Alejandra , Vázquez Hebe , Zamora Natalia , Carlevaris Leandro , Felquer María Laura , Scarafia Santiago , Vergara Facundo , Citera Gustavo , De la Vega María Celina , García Lucila , García Salinas Rodrigo , Gómez Jimena , Lázaro María Alicia , Morales Serrano Rosa
Published: March 2022

Aumento del riesgo de infecciones prevenibles y sus complicaciones en pacientes con enfermedades reumáticas inflamatorias crónicas (ERICA), con y sin tratamiento con inmunosupresores (IS), y beneficios de la vacunación.
Consenso de recomendaciones de vacunas en adultos con enfermedades reumáticas inflamatorias crónicas autoinmunes. Suplemento 2
Authors: De Reumatología Sociedad Argentina , De Infectología Sociedad Argentina
Published: March 2022

Suplemento 2. Tablas de evidencia
Giant Cell Tumor of the Middle Phalanx of Ring Finger Treated with Wide Excision and Reconstruction using Non-vascularized Fibular Graft: A Rare Case Report and Review of Literature
Authors: Rahyussalim Ahmad Jabir , Fladimir Makabori Januar Chrisant , Labib Zufar Muhammad Luqman , Kurniawati Tri
Published: March 2022

Giant cell tumor (GCT) involving the hand, specifically the phalangeal bones, is very rare, accounting for only 2% of cases of the bone. This type of GCT is associated with more aggressive behaviour and higher recurrence and metastasis rate. We present a rare case of large GCT of the middle phalanx of ring finger in a 33 year old female. The patient was treated with wide excision and reconstruction using non-vascularized fibular graft. At her most recent follow-up time, 1 year post-surgery, the patient showed no symptoms with neither complication nor recurrence reported.
Management of Shunt complication in a Paediatric COVID 19 Case in Bangladesh Medical College Hospital
Authors: Huda N  , Gomes VC  , Chowdhury M  , Hamid R
Published: March 2022

V-P shunt is the most common surgery done in paediatric hydrocephalus. Though the surgery remains as ‘minor’ in the arena of Neurosurgery, its complication surpass any boundary. Here we discuss a case of shunt complication which had malfunctioning shunt with both end malposition, cranial end occluded by septum and cortex and peritoneal end invading bowel. Surgery was taking a new course for dramatic appearance of COVID 19.
The Role of 3D Printing in the Positioning of the Glenoidal Component in Total Shoulder Arthroplasty. An Experimental Study
Authors: NA Netto , JC Belloti , F Faloppa , FT Matsunaga , E Vásquez-Alvarez , MJS Tamaoki
Published: March 2022

The total shoulder arthroplasty is the surgical treatment when the non-surgical treatment fails. The key point of this procedure is the correct implantation of the glenoidal component to avoid the loosening and to promote long term survival of the implant. Despite of the use of medical images resources in pre-operative planning, this procedure continues to be challenging due to difficulties in the correct spatial positioning of the components. The 3D print brought the possibility to reproduce the anatomy of the patient being helpful in the pre-operative planning, due to the real tridimensional characteristics. The objective of this study is to evaluate the positioning of the glenoidal component in total shoulder arthroplasty comparing the use of TC scans and anatomic 3D print models, from patients with shoulder osteoarthritis, in the pre-implantation planning. From nine consecutive patients submitted to a total shoulder arthroplasty were generated 54 3D print scapula models, used for implant polyethylene glenoid component, hiding the anatomic parameters like in a real surgery, done by three intervenors in a randomized way, using in the pre-operative planning the correspondent CT scans or the anatomic 3D printing scapula. The angular positioning in anteroposterior view and axillary view related to the scapula body, was evaluated with X-Ray, and measured by tree independent evaluators. It was no significant difference when comparing the measures of angulation of the implantation of glenoidal components in osteoarthritis scapula models, when comparing the use of the TC scans or the 3D print scapula models in pre-implantation planning, with exception founded in one intervenor, in anteroposterior view, in favor of 3D printing model. When comparing the use of 3D printed scapula and TC scans for planning the implantation of glenoidal component in total shoulder arthroplasty, both methods proved to be equivalent.
Anesthetic Management for Patients With Pheochromocytoma : Series of Three Cases
Authors: LE Imbelloni , Neto SV Lemos , ALC Rivoli , AR Rosário , LV Salomão , TG Borges
Published: March 2022

1.1. Background. This study describes a case series that addresses the complex anesthetic management of adrenalectomy for patients with pheochromocytoma. It is a rare tumor, originating in the chromaffin cells of the adrenal medulla and a catecholamine-secreting agent, whose most common triad of symptoms is headache, sweating and tachycardia. 1.2. Cases: The first case corresponds to a 47-year-old woman with a history of three acute myocardial infarctions with a lesion located unilaterally in the left adrenal gland. After adrenal removal and due to persistence of hypertension, it was necessary to perform a left nephrectomy. The second case describes the conduction of a multimodal and opioid-free anesthesia of a 26-year-old female patient with dilated cardiomyopathy who underwent video laparoscopic right adrenalectomy The first report involves the case of a 14-year-old male patient with von Hippel-Lindau Syndrome, who underwent bilateral open adrenalectomy. All three cases were successfully preoperatively prepared and operated on and were discharged home between the 5th and 6th day compensated and without physiological changes. No genetic study of the three patients was performed. Continuous epidural anesthesia was performed in two patients, without hypotension and need for vasopressor. 1.3. Conclusion: In this pathology, it is essential to emphasize the extreme importance of the multidisciplinary approaches carried out in the three cases. We can affirm affirm that the favorable outcomes were only possible thanks to a great joint effort and judicious for monitoring the Endocrinology and Pediatrics services and for the coordinated relationship between the anesthetic and surgical teams, which were essential for obtaining hospital discharge in the first six days after surgery
Deep Neural Network with Adaptive Parametric Rectified Linear Units and its Fast Learning
Authors: Bodyanskiy Yevgeniy , Deineko Anastasiia , Skorik Viktoria , Brodetskyi Filip
Published: March 2022

The adaptive parametric rectified linear unit (AdPReLU) as an activation function of the deep neural network is proposed in the article. The main benefit of the proposed system is adjusted activation function whose parameters are tuning parallel with synaptic weights in online mode. The algorithm of the simultaneous learning of all neurons parameters with AdPReLU and the modified backpropagation procedure based on this algorithm is introduced. The approach under consideration permits to reduce volume of the training data set and increase tuning speed of the DNN with AdPReLU. The proposed approach could be applied in the deep convolutional neural networks (CNN) in conditions of the small value of training data sets and additional requirements for system performance. The main feature of DNN under consideration is possibility to tune not only synaptic weights but the parameters of activation function too. The effectiveness of this approach is proved by experimental modeling.
Cervical Cancer Diagnosis System using Convolutional Neural Network ResidualNet
Authors: Novitasari Dian C. Rini , Wulandari Putri , Haq Dina Zatusiva
Published: March 2022

Cervical cancer is a deadly disease attacking women. It represents 6.6% of all female cancers. The stadium of cervical cancer is determined based on the presence of carcinoma. The cervical cancer classification system can be used to help medical workers to analyze the stadium of cervical cancer. In this study, cervical cancer stages were divided into five classes, namely, normal cervix, stadium I, stadium II, stadium III, and stadium IV based on colposcopy images. The proposed method is one of deep learning methods, that is convolutional neural network (CNN) using deep residual network (ResidualNet) architecture. This study compared ResidualNet-18, ResidualNet-50, and ResidualNet-101 models and some conventional methods. The comparison results show that ResidualNet is more accurate than conventional methods. From the experiment, based on the accuracy value and elapsed time, ResidualNet-50 is worth using for cervical cancer classification. The result of this evaluation is higher than the maximum achievement of the ResidualNet-18 architecture. In addition, the elapsed time of the classification process using the ResidualNet-50 architecture with the accuracy, sensitivity, and specificity values reaching 100% is shorter than ResidualNet-101, which is 4397 s.
A Real-Value Parameter Function Optimization Algorithm using Repeated Adaptive Local Search
Authors: Auwatanamongkol Surapong
Published: March 2022

A simple and easy to implement but very effective algorithm for solving real-value parameter optimization problems is introduced in this paper. The main idea of the algorithm is to perform a local search repeatedly on a prospective subregion where the optimal solution may be located. The local search randomly samples a number of solutions in a given subregion. If a new best-so- far solution has been found, the center of the search subregion is moved based on the new best-so-far solution and the size of the search subregion is gradually reduced by a predefined shrinking rate. Otherwise, the center of the search is not moved and the size of the search subregion is reduced using a predefined shrinking rate. This process is repeated for a number of instances so that the search is focused on a gradually smaller and smaller prospective subregion. To enhance the likelihood of achieving an optimal solution, many rounds of this repeated local search are performed. Each round starts with a smaller and smaller initial search space. According to the experiment results, the proposed algorithm, though very simple, can outperform some well-known optimization algorithms on some testing functions.
Klasifikasi Jenis Alat Musik Tradisional Papua menggunakan Metode Transfer Learning dan Data Augmentasi
Authors: Solihin Amat , Mulyana Dadang Iskandar , Yel Mesra Betty
Published: March 2022

Papua merupakan sebuah pulau yang terletak di sebelah utara Australia dan merupakan bagian dari wilayah timur Indonesia yang sebagian besar daratannya masih berupa hutan belantara dan merupakan pulau terbesar kedua di dunia setelah Greenland. Papua terkenal akan aneka budayanya, termasuk kekayaan alat musik. Ada berbagai jenis alat musik tradisional Papua yang menawan dan memiliki sejarah musik tradisional mendalam dibaliknya. Alat musik ini biasa digunakan untuk mengiringi acara adat maupun pesta. Perkembangan teknologi saat ini dan di tengah perkembangan musik kontemporer di Papua, ada kegelisahaan akan hilangnya musik-musik tradisi yang sangat kaya beragam sesuai kebudayaan masing-masing wilayah di Papua. Oleh karena itu, peneliti membuat program pengenalan citra alat musik tradisional Papua menggunakan metode Transfer Learning, yang merupakan metode dari Convolutional Neural Network yang merupakan operasi konvolusi dengan melatih terlebih dahulu pada model sebelumnya yang kemudian menggabungkan beberapa lapisan pemrosesan, menggunakan beberapa elemen yang bergerak secara paralel dan terinspirasi oleh sistem saraf biologis. Citra alat musik Papua yang digunakan adalah Fue, Pikon, Triton, Yi dan Tifa. Implementasi pengenalan citra ini dilakukan dengan memanfaatkan Pre-Trained model dari DenseNet201 yang berjalan pada aplikasi Google Collaboratory dan Tensorflow. Dataset yang digunakan dalam pengujian sebanyak 979 data training dan 143 data testing yang mengahasilkan nilai evaluasi dengan nilai precision 98%, recall 98%, f1-score 98%, accuracy 98,46% dan loss 0.051.
Para que «não se demore o resgate desta alma nos cárceres do Purgatório»: a Ordem Terceira de São Francisco do Recife e o cumprimento dos testamentos dos irmãos falecidos (Pernambuco, Brasil, 1701-1795)
Authors: de Souza Martins William
Published: March 2022

O artigo analisa a atividade de satisfação das últimas vontades dos irmãos que haviam escolhido a Ordem Terceira de São Francisco do Recife como testamenteira ou herdeira dos seus bens. Para tanto, foram selecionados dois casos, dentre os fiéis que deixaram heranças mais importantes à administração da Ordem: os irmãos Antônio Fernandes de Matos (c. 1646-1701) e Luís Cardoso (c. 1655-1721). A partir da documentação da Capitania de Pernambuco do Arquivo Histórico Ultramarino de Lisboa, disponível on line, o texto busca discutir as demandas judiciais em que esteve envolvida a Ordem Terceira de São Francisco durante a administração dos legados testamentários desses irmãos. A dispersão das heranças acumuladas e as disputas com as autoridades da Coroa e com os herdeiros prolongaram durante décadas a administração das heranças outorgadas pelos irmãos em questão. O estudo pretende mostrar tanto as dificuldades como a importância das atividades da Ordem como testamenteira de ricos irmãos falecidos, tema pouco analisado pela historiografia dedicada às associações de irmãos terceiros.
Development of Ozonated Water Technology to Inhibit Enzymatic Browning of “Mang-Koot-Cut”
Authors: Chankuson Pitchasak , Nisoa Mudtorlep , Srinum Thammanoon
Published: March 2022

This work aim to produce high-concentration ozonated water using a dielectric barrier discharge for inhibiting the enzymatic browning of Mang-Koot-Cut. The ozonizer was composed of radio frequency (RF) powered mesh electrode and grounded water electrode that sandwiched a Pyrex glass tube as the dielectric material. The discharge of air flowing through the ozonizer generated ozone gas. The optimal flow rate was 2 L/min. A venturi injector caused an effective mixing between ozone gas and water to obtain ozonated water. The RF power, discharge time and airflow rate controlled the dissolved ozone concentration. Ozonated water with dissolved ozone concentrations greater than 0.2 ppm could reduce the browning reaction of Mang-Koot-Cut. Measurement of the color values L*, a* and b* showed that ozonated water could delay the browning of Mang-Koot-Cut. The results exhibited the possibility of using ozonated water to reduce the browning activity in Mang-Koot-Cut as a substitute for chemicals that are harmful to health. Ozonated water is green chemistry with no toxic residues.

HIGHLIGHTS

The developed ozonated water production system can generate a concentration of about 0.3 ppm

Ozonated water can inhibit the enzymatic browning reaction caused by the PPO enzyme and phenol compounds

GRAPHICAL ABSTRACT