bluuebunny/crossref_metadata_2025 huggingface dataset:
A rare cause of primary adrenal insufficiency due to a homozygous Arg188Cys mutation in the STAR gene
Authors: Burget Lukas , Parera Laura Audí , Fernandez-Cancio Monica , Gräni Rolf , Henzen Christoph , Flück Christa E
Published: March 2018

Steroidogenic acute regulatory protein (STAR) is a key protein for the intracellular transport of cholesterol to the mitochondrium in endocrine organs (e.g. adrenal gland, ovaries, testes) and essential for the synthesis of all steroid hormones. Several mutations have been described and the clinical phenotype varies strongly and may be grouped into classic lipoid congenital adrenal hyperplasia (LCAH), in which all steroidogenesis is disrupted, and non-classic LCAH, which resembles familial glucocorticoid deficiency (FGD), which affects predominantly adrenal functions. Classic LCAH is characterized by early and potentially life-threatening manifestation of primary adrenal insufficiency (PAI) with electrolyte disturbances and 46,XY disorder of sex development (DSD) in males as well as lack of pubertal development in both sexes. Non-classic LCAH manifests usually later in life with PAI. Nevertheless, life-long follow-up of gonadal function is warranted. We describe a 26-year-old female patient who was diagnosed with PAI early in life without detailed diagnostic work-up. At the age of 14 months, she presented with hyperpigmentation, elevated ACTH and low cortisol levels. As her older brother was diagnosed with PAI two years earlier, she was put on hydrocortisone and fludrocortisone replacement therapy before an Addisonian crisis occurred. Upon review of her case in adulthood, consanguinity was noted in the family. Genetic analysis for PAI revealed a homozygous mutation in the STAR gene (c.562C>T, p.Arg188Cys) in both siblings. This mutation has been previously described in non-classic LCAH. This case illustrates that early onset, familial PAI is likely due to autosomal recessive genetic mutations in known genes causing PAI.

Learning points:

In childhood-onset PAI, a genetic cause is most likely, especially in families with consanguinity.

Adult patients with an etiologically unsolved PAI should be reviewed repeatedly and genetic work-up should be considered.

Knowing the exact genetic diagnosis in PAI is essential for genetic counselling and may allow disease-specific treatment.

Young men and women with NCLAH due to homozygous STAR Arg188Cys mutation should be investigated for their gonadal function as hypogonadism and infertility might occur during puberty or in early adulthood.
Comparison of the Relative Potential for Epigenetic and Genetic Variation To Contribute to Trait Stability
Authors: Aller Emma S T , Jagd Lea M , Kliebenstein Daniel J , Burow Meike
Published: March 2018

The theoretical ability of epigenetic variation to influence the heritable variation of complex traits is gaining traction in the study of adaptation. This theory posits that epigenetic marks can control adaptive phenotypes but the relative potential of epigenetic variation in comparison to genetic variation in these traits is not presently understood. To compare the potential of epigenetic and genetic variation in adaptive traits, we analyzed the influence of DNA methylation variation on the accumulation of chemical defense compounds glucosinolates from the order Brassicales. Several decades of work on glucosinolates has generated extensive knowledge about their synthesis, regulation, genetic variation and contribution to fitness establishing this pathway as a model pathway for complex adaptive traits. Using high-throughput phenotyping with a randomized block design of ddm1 derived Arabidopsis thaliana epigenetic Recombinant Inbred Lines, we measured the correlation between DNA methylation variation and mean glucosinolate variation and within line stochastic variation. Using this information, we identified epigenetic Quantitative Trait Loci that contained specific Differentially Methylated Regions associated with glucosinolate traits. This showed that variation in DNA methylation correlates both with levels and variance of glucosinolates and flowering time with trait-specific loci. By conducting a meta-analysis comparing the results to different genetically variable populations, we conclude that the influence of DNA methylation variation on these adaptive traits is much lower than the corresponding impact of standing genetic variation. As such, selective pressure on these traits should mainly affect standing genetic variation to lead to adaptation.
Assessing the Genetic Landscape of Animal Behavior
Authors: York Ryan A
Published: March 2018

Recent years have seen an increase in studies that associate genomic loci with behavioral variation both within and across animal species. Ryan York compiles and analyzes over 1,000 of these loci, finding that the genetic...

Although most animal behaviors are associated with some form of heritable genetic variation, we do not yet understand how genes sculpt behavior across evolution, either directly or indirectly. To address this, I here compile a data set comprised of over 1000 genomic loci representing a spectrum of behavioral variation across animal taxa. Comparative analyses reveal that courtship and feeding behaviors are associated with genomic regions of significantly greater effect than other traits, on average threefold greater than other behaviors. Investigations of whole-genome sequencing and phenotypic data for 87 behavioral traits from the Drosophila Genetics Reference Panel indicate that courtship and feeding behaviors have significantly greater genetic contributions and that, in general, behavioral traits overlap little in individual base pairs but increasingly interact at the levels of genes and traits. These results provide evidence that different types of behavior are associated with variable genetic bases and suggest that, across animal evolution, the genetic landscape of behavior is more rugged, yet predictable, than previously thought.
Neoliberalismo democrático y deuda externa. Lecciones del caso argentino
Authors: Castorina Emilia
Published: March 2018

El objetivo de este trabajo es aproximar una definición de neoliberalismo democrático que de cuenta del poder estructural que tienen los capitales concentrados en las democracias actuales: un terreno de disputa de poder que tiende a institucionalizar desigualdades políticas en la medida en que instaura sistemas de toma de decisiones por fuera del alcance y control de las mayorías. En las llamadas “nuevas democracias”, entre las cuales el caso argentino es paradigmático, el endeudamiento externo condiciona los procesos de democratización, por lo tanto un breve análisis de la deuda externa desde la dictadura militar hasta el reciente conflicto con los “fondos buitres“, intentará ilustrar el poder político del capital financiero, el cual se ha visto recientemente fortalecido por el ascenso al poder de un nuevo gobierno neoliberal.
Elementos para periodizar la violencia en Colombia: dimensiones causales e interpretaciones historiográficas
Authors: Villamizar Juan Carlos
Published: March 2018

Este artículo examina los elementos económicos y políticos que permiten periodizar la violencia en Colombia en los siglos XX y XXI, además de observar su construcción conceptual y las consecuencias que de tales interpretaciones se derivan. Para ello, la primera sección presenta datos sobre la magnitud e impacto de la violencia; la segunda discute sobre las dimensiones causales del conflicto; la tercera presenta las interpretaciones historiográficas más relevantes; la cuarta presenta conclusiones.
La Economía del carbono: Una adicción de difícil tratamiento
Authors: Sanabria Álvaro
Published: March 2018

El cuadragésimo quinto presidente de los Estados Unidos de Norteamérica, Donald Trump —magnate de la construcción y los casinos, y figura del insustancial mundo del espectáculo televisivo—, tuvo como lema de su campaña “hacer nuevamente grande a Estados Unidos” (Make America Great Again, fue la frase en inglés), sin que en ningún momento precisara su sentido. Sin embargo, en un período muy corto desde la asunción del mando, el eje central de la estrategia dejó emerger el mundo imaginado que escondía el eslogan. El nombramiento de Rex Tillerson, director ejecutivo de Exxon Mobil, como Secretario de Estado; de Scott Pruit —escéptico del cambio climático, defensor de la industria del petróleo y varias veces demandante de la Agencia de Protección del Medio Ambiente de EE.UU (conocida como EPA, por sus siglas en inglés)—, como director de la institución objeto de sus ataques; así como la derogación de la ley de regulaciones a la explotación del carbón, que tenía como objetivo proteger los cuerpos de agua de los desperdicios de la extracción del mineral; el retiro del Acuerdo de París sobre cambio climático y, más recientemente, la derogación del Plan de Energía Limpia (CPP, por sus siglas en inglés) son hechos más que suficientes, que permiten concluir que, más allá del proteccionismo, la reindustrialización o el regreso al bilateralismo en las relaciones internacionales, el principio fundante de la nueva política estadounidense tiene su base material y estratégica en situar, nuevamente, en el centrode la escena la producción y comercialización de los combustibles fósiles.
Prieto, S. (Coord.). (2017). Reflexiones sobre el género, el cuerpo y el poder. Cinco voces trans en diálogo con Judith Butler. Bogotá D. C.: Universidad Nacional de Colombia, Unidad de Investigaciones Jurídico-Sociales Gerardo Molina, Unijus. 204 pp
Authors: Barrera Andrea
Published: March 2018

Este conjunto de reflexiones que se presentan bajo la forma de un libro académico son el resultado de un esfuerzo colectivo por establecer un diálogo con una de las (quizás la) pensadoras más conocidas de las teorías queer con las experiencias vitales de cinco personas trans (cuatro mujeres trans y una persona que transita en el género). Dicho esfuerzo da cuenta del interés por superar una lectura y, sobre todo, una aplicación mecanicista de un conjunto de conceptos de una teoría cuyos potenciales explicativos son no solo valorados por las autoras del texto, sino que además buscan ser puestos en cuestión y complementados por medio de las experiencias de las personas que aceptaron ser entrevistadas en el marco de la investigación.
„Pleinair erfunden …” adalékok Csontváry plein air-tanulmányaihoz (1897–1903)
Authors: Kaszás Gábor
Published: March 2018

There is still much to be explored about the exact circumstances of the creation of Csontváry’s pictures and the painter’s working method. Research has either approached the oeuvre from the life path wrought with mythical elements, or wished to embed it in the context of 19th century painting tradition. From these angles, however, the consistently built visual logic of Csontváry’s pictures, their details governed by the inherent laws of the genre of painting are often overlooked.

The most adequate method of exploring Csontváry’s creative practice appears to be a thorough examination of the relation between the inspiring sight and the picture painted of it. I based this study on Csontváry’s landscapes painted between 1897 and 1905, first of all those painted in Trogir, Castellammare and Taormina. In the knowledge of these localities it can be established that the painter accurately followed the topographic sight and the conditions of light. At the same time, the comparison of the location and the painting has also revealed that the painter had pairs of pictures in mind in his intention to capture a sight systematically. Taking up a vantage point mostly in northsouth and one in east-west orientation, he created “panorama pictures” built of several elements. His paintings are similar to the 360° panoramas in photography. But while a rotating camera can take an infinite number of photos, the painter assembled the picture from two “shots”.

Conspicuously, the pairs of pictures depict different times of day: instead of momentary impressions and moods, Csontváry captured the path of the transmission of light and thereby the passing of time, an interval of time in the pairs of pictures. In his later compositions he was to apply these different light conditions in a single picture, framing as it were the daily path of the planet on the horizon. This practice is related to one of Csontváry’s key technical terms, the “Sun Path”.

By capturing the changing of light in one picture Csontváry wished to “perfect” the 19th century plein air technique. His “Sun Path” painting derives from a specific view of nature and the world, which was in polar opposition to the positivism of naturalism and the sensualism of impressionism. Proof of it is the pairs of pictures. They summarize all Csontváry’s observations of time and space, and their translation into the practice of painting.

The views conveyed by Csontváry’s paintings were often borrowed from contemporaneous picture postcards. Not only greeting cards but e.g. the rich moving picture and photo material of the programs of the Urania Hungarian Scientific Theatre inspired him. He treated the pictorial themes as visual tropes or conventions, but in the creative process he only used their fixed, symbolic form such as a typical cutting. When a theme was actually to be realized, he thought it indispensable to be on the site in person, to make sketches and paint on the spot. He did so to make the contents he found important in the symbol visible by his painting.
A „falak is szenvednek” – épület(sorsok) és kutató(sorsok) 1945–1963
Authors: Bardoly István
Published: March 2018

When the fighting was over in Budapest in 1945, the National Commission of Monuments (MOB) immediately began assessing the damage the historic monuments had suffered from military action and from the plunderingravaging population. The worst plight befell the stock of castles and mansions. The new situation also shed light on the contradictions and defects of the institution’s functioning. Many of the provisions of Act 39 of 1881 regulating the protection of historic monuments had become out-of-date. The local governments were unable to impose their will during the redistribution of land and the ensuing expropriation of property begun in March 1945 even in the few cases in which they were determined to protect the buildings.

After lengthy negotiations the representative of MOB was eventually co-opted by the Ministry of Agriculture’s committee in charge of nationalizing the castles and country houses and deciding on their new function, but this remained a purely administrative presence. Although a ministerial order of 1946 spelt out the responsibility of the owner or user in maintaining the monument, the spontaneous transformation of these buildings went on without the knowledge or guidance of institutionalized monument protection, and that resulted in the further deterioration of the already damaged buildings. Another problem was the lack of adequate information at MOB on the 19th century building stock; they only launched more thorough assessment of this area after 1922. Research literature elaborating this period began to appear as late as in 1936.

In late 1949 the tasks of MOB were taken over by the National Center of Museums and Monuments, also assuming professional control of museums. The small group of outstanding experts at monument protection fostered the best tradition of Hungarian monument management started in 1872, doing their utmost for the saving of the building stock. The appendix provides a selection of pertinent documents.
Kísérlet néhány magyarországi ötvösjegy feloldására XVI
Authors: Grotte András
Published: March 2018

Going on with a series of articles, I present again some so-far unknown maker’s marks and mark variants in private collections and the art trade, and try to identify them. When already published marks are at issue, Elemér Kőszeghy’s book of marks is referred to, and Ilona P. Brestyánszky’s work is mentioned with the mark’s serial number there when marks of Pest-Buda are discussed. I try to clarify the biography of goldsmiths active in Hungarian towns on the basis of archival research, first of all with parish register data. In the appendix I give a list of gold- and silversmiths named in the registers of the Israelite community of Óbuda between 1851 and 1895, and those in the census of 1850.
Binder János Fülöp metszetei a máriaradnai kegyképről a budai Landerer-nyomda kiadványaiban (1762–1771)
Authors: Bánfi Szilvia
Published: March 2018

The miraculous escape of the icon of Máriaradna representing Our Lady of the Carmel Mountain (originally a coloured woodcut sheet of Italian origin) had a longlasting effect on 18th century Hungarian popular religious literature. To our present knowledge the Landerer printing workshop issued it between 1756–1771/1773? in Latin, Hungarian and German languages, in altogether seven editions. The unknown author tells how the icon escaped and also the miraculous events effected by the icon. From 1762 on these editions were decorated with illustrations: an engraved frontispiece and a series of engraved images telling the history of the icon. Later beside the engraved series of images woodcut technique was also employed.

As a result of the systematic reconstruction of the typographical and decorative elements employed in the Landerer-press carried on by the author several new facts can be stated. First of all, the Landerer office employed three variants of the engraved frontispiece, of which the first was the one signed by Johann Philipp Binder in the 1762 Hungarian edition. The next was a variant, an after-cut of Binder’s, while the third is an image of quite different concept as compared to the previous two ones, although all the three represent Our Lady of Radna, with the child Jesus, and the church of Máriaradna, the place of worship. The two later ones were used from 1771 and were the products of the copper-plate engraving workshop in Buda founded by Binder. The practice of the workshop was to sign their works only shortly as „Binder”. The series of engraved illustrations telling the history of the shrine was also used from 1762 on, but some time between 1771 and 1773 the pictures were copied to woodcuts, probably also in the Binder workshop. Although the paper highlights on the 18th century Buda editions of the miracle book and its illustration, mention is also made on the survival and after-life of illustrations related to the Máriaradna icon.
Anyakönyvi adatok „pozsonyi Dorfmeister Istvány” (Stephan Anton Dorffmaister, Pozsony 1741 — Sopron 1797) származásához és pályakezdéséhez
Authors: Jávor Anna
Published: March 2018

The newly acquired register data reveal that the Viennese baroque painter, the younger brother of sculptor Johann Georg Dorfmeister (1736-1786) and cousin of the painter Johann Evangelist Dorfmeister (1742-1765) was born on 13 October 1741 in Pozsony. The signature of one of his pictures already divulged his age and he specified his place of birth for his marriage in Kremsier (Kroměříž) in 1762 correctly. The uncertainty prevailing so far was caused by a mistake in the death register in Sopron, as the deceased was registered as aged 68 in 1797, as well as by the fact that the populous Dorffmaister family – of shoemakers and embroiderers – living on Spittelberg did not have any son called Stephan registered at the St Ulrich parish of Vienna. His marriage data corroborates the so-far only presumed role of the Premonstratensians of Hradisch (Hradisko u Olomouce) in Dorffmaister’s career start in Hungary. While the decoration of the Premonstratensian church and monastery of Türje in west Hungary painted between 1761 and 1763 is being brought to light in its increasing richness as restoration progresses, there is no trace remaining of the painter’s work done for the Promonstratensians of Csorna, and moreover, the relevant sources are also uncertain. Research in the archives of the Premonstratensian abbey of Hradisch kept in Brno will hopefully bear further fruit.
Variációk egy témára. Oskar Kokoschka litográfia-sorozata a Hatvany Lajos Múzeum gyűjteményében
Authors: Pallag Márta
Published: March 2018

The paper is concerned with Oskar Kokoschka’s (1886–1980) set of ten lithographs entitled Variations on a theme preserved in the art collection of the Hatvany Lajos Museum in Hatvan. After detailing the genesis of the graphic sheets, the author concentrates on the provenance of the series. The large facsimile edition of the series was owned by the Hatvany family until World War II and it went to the public collection of the town of Hatvan via purchasing in 1974. The artistic connections of the Hatvan branch of the industrial magnates Deutsch family were widely ramifying. In the studied period the art patronage by painter and art collector Ferenc Hatvany (1881–1958) and patron of literature and public figure Lajos Hatvany (1880–1961) was daily practice. The series was probably not included in the excellent collection of Ferenc Hatvany, who was a resolute and conscious art collector interested first of all in the classic artists of French impressionist, post-impressionist and realist painting. Known so far only for his literary patronage, Lajos Hatvany’s explored connections with artists confirm that he was in direct contact with both Oskar Kokoschka and his art patron in Berlin, the aristocrat Paul Cassirer.
A magyar Királyi Pénzügyminisztérium egykori palotája a budai várban
Authors: Prakfalvi Endre
Published: March 2018

In the Austro-Hungarian Monarchy financial affairs remained the sovereign right of the Hungarian Kingdom. In the decades after the Compromise (1867) the finance ministry functioned at several separate venues in Buda Castle. Without calling a plan competition, finance minister László Lukács commissioned architect Sándor Fellner (1857-1944) to design a building complex that would house the entire ministry, and 4 million crowns were earmarked in article XXXIV of 1900 for the construction. The sketches submitted by Fellner, who started his studies in the forerunner of the Budapest Technical University and completed them in Vienna and Paris, were approved on the very last day of the 19th century. In terms of function, the design adopted the cell model, providing each official a room of his own. The rooms were separated and only accessible from lateral corridors. The most attractive appearance was given to the wing with the main staircase and state-room in Szentháromság square. The pair of towers flanking the projecting central section were crowned by roofs adopting the outline of the gothic tower cap of Maria am Gestade in Vienna. The brass knights on the pinnacles also reminded of the Rathausmann of the imperial city. The first section of the lateral wing in Hess András square contained the minister’s suite of rooms, the wing across from it in Országház street included the secretary of state’s offices and representative rooms. The ceremony of laying the foundation stone was held in spring 1901 and the capping celebration was on 19 September 1902, the centenary of Lajos Kossuth’s birth. (Female day-wage labourers got 2 crowns bonus, the chief master builder received 1500 crowns.) The palace, which caused controversy among contemporaries as well (Wasn’t it in conflict on account of its volume and forms with the architecture of the Matthias Church, the church of coronations, renovated by Frigyes Schulek?) could be occupied in late 1904. In terms of innovation and engineering, the archival wing was outstanding, a witness of early Hungarian concrete iron constructions documented by sources. Built with great craftsmanship and abounding in splendid details – equipped lavishly with materials and products from all over historical Hungary – the palace, which represented its status well, was badly damaged in the siege of Buda in 1944/45 (Festung Budapest). The architect, whose active career of sixty years was acknowledged by his admission to the Incorporated Architects & Surveyors (London) in 1937, did not live to see the crumbling of the walls. The monument he had designed in the Jewish cemetery in Kozma street only features his wife’s name who died young (1907). The new looks of his building resulted from the reconstruction led by Jenő Rados (1947-1950). A contemporary critic with the fresh outlook of the new era declared that the resulting simplified form, particularly of the main façade, turned the former Finance Ministry into a truly monumental building.
PEMETAAN GEOLOGI GUNUNG API BAWAH LAUT KAWIO BARAT PERAIRAN SANGIHE-TALAUD MENGGUNAKAN MULTIBEAM ECHOSOUNDER RESOLUSI TINGGI
Authors: Triarso Eko , Arief Troa Rainer
Published: March 2018

Indonesia terletak pada lingkaran cincin api Pasifik yang merupakan jalur gunung api. Gunung api ini tidak hanya terdapat di darat tetapi juga di laut. Potensi yang ada pada wilayah sekitar gunung api tidak hanya berupa potensi bencana tetapi juga terdapat mineral ekonomis. Penelitian gunung api bawah laut masih sangat jarang dilakukan. Ekspedisi laut dalam di kawasan perairan Sangihe-Talaud telah dilaksanakan atas kerjasama antara Badan Litbang KP, Kementerian Kelautan dan Perikanan dengan National Oceanic Atmospheric Administration (NOAA), USA. Ekspedisi ini dilakukan dari tanggal 24 Juni hingga 6 Agustus 2010 dengan nama INDEX-SATAL (Indonesia Expedition Sangihe-Talaud), dimana salah satu tujuan dari ekspedisi ini adalah pemetaan detil dasar laut menggunakan multibeam echosounder. Pengolahan ulang data batimetri menghasilkan kenampakan pola struktur maupun morfologi gunung api bawah laut yang tumbuh pada Lembah Sangihe. Gunung api bawah laut Kawio Barat memperlihatkan kenampakan berbentuk kerucut ideal yang timbul dari kedalaman 5400 meter di bawah permukaan laut dengan puncaknya mencapai kedalaman 1890 meter di bawah permukaan laut. Kenampakan morfologi gunung api bawah laut Kawio Barat ini memperlihatkan bagian barat laut dari gunung api ini memiliki tekstur yang lebih kasar dibandingkan pada bagian di sebelah tenggaranya yang bertekstur lebih halus. Hal tersebut mengindikasikan produk vulkanik di sebelah barat laut berumur lebih tua dibandingkan dengan di sisi tenggara. Perbedaan itu dibatasi oleh lembah yang memanjang dari utara ke barat daya.
ZONASI INTRUSI AIR ASIN DENGAN KUALITAS FISIK AIR TANAH DI KOTA SEMARANG
Authors: Gunawan Pryambodo Dino , Prihantono Joko , - Supriyadi
Published: March 2018

Air tanah sering digunakan sebagai sumberdaya air untuk keperluan air bersih dan air minum. Kebutuhan air tanah di kota-kota besar seperti kota Semarang terus meningkat seiring dengan bertambahnya jumlah penduduk. Meningkatnya jumlah penggunaan air tanah di wilayah pesisir Kota Semarang mengakibatkan terjadinya intrusi air asin yaitu masuknya air laut kedalam air tanah. Tujuan penelitian ini adalah untuk membuat peta zonasi penyebaran intrusi air asin di wilayah kota Semarang. Sebaran intrusi air asin dilakukan dengan menguji kualitas air tanah secara langsung (insitu) dengan alat multi-parameter water quality meters WQC 24 TOA DKK. Nilai yang diuji antara lain pH, salinitas dan dayahantar listrik (DHL). Hasil penelitian menunjukkan nilai pH didaerah penelitian sebagian besar berada diatas 7,5 dalam hal ini bersifat basa yang masuk dalam batasan air payau. Nilai Salinitasnya bernilai diatas 0,5 ‰ hal ini sudah masuk dalam katagori air payau. Nilai Daya Hantar Listrik (DHL) air tanahnya diatas 900 µmhos/cm yang mengakibatkan berubahnya fungsi air tanah menjadi air payau. Ketiga peta sebaran nilai kualitas air tanah (pH, Salinitas, DHL) tersebut disajikan dengan peta zonasi untuk mengetahui pola sebaran intrusi air asin di wilayah kota Semarang. Peta zonasi di buat menjadi tiga zona yaitu zona air tawar, zona air payau, zona air asin, sebagian besar wilayah kota semarang fungsi air tanahnya sudah berubah menjadi air payau, untuk zona air tawar terdapat di wilayah semarang selatan.
KONDISI KESEHATAN KARANG DI PULAU – PULAU KECIL TELUK JAKARTA
Authors: - Dedi , Arifin Taslim
Published: March 2018

Tingkat pencemaran perairan Teluk Jakarta yang terjadi diakibatkan aktivtas dari daratan memberikan dampak pada perairan di sekitarnya.Terumbu karang sangat dipengaruhi oleh kondisi lingkungan. Tujuan penelitian ini untuk mengetahui kondisi kesehatan karang melalui persen tutupan karang hidup, sebaran dan kelimpahan penyakit dan hubungan antara persen tutupan karang dengan kelimpahan penyakit karang.Pengamatan dilakukan dengan menggunakan metode transek sabuk 1 x 1 m dengan transek garis dengan panjang transek 50 m pada kedalaman 3 m, dilakukan pada 5 lokasi, 3 stasiun di Gugusan Pulau Pari dan 2 stasiun pada pulau yang berdekatan dengan Teluk Jakarta. Untuk mengetahui kondisi terumbu karang dilakukan analisis dengan menghitung persen tutupan karang hidup, prevalensi penyakit karang, kelimpahan koloni yang terserang penyakit karang. Hubungan antara tutupan karang hidup, prevalensi penyakit karang, dan kelimpahan penyakit karang dianalisis dengan metode regresi linier. Secara umum kondisi terumbu karang pada lokasi yang berdekatan dengan teluk Jakarta dikategorikan sangat buruk (0,56% - 5,05%) sedangkan pada gugusan Pulau Pari dikategorikan sedang (17,88% - 41,27%). Kelimpahan penyakit karang yang ditemukan 17 koloni White Syndrom, 65 koloni putih, 2 koloni Brown Band Disease, 1 koloni Skeletal Eroding Band sedangkan kategori gangguan kesehatan karang seperti Fish bite (4 koloni), Drupellla (2 koloni), Crown-Of-Thorns Starfish (COTS) (1 koloni), Pigmentation Respon (31 koloni), Invertebrate Galls (13 koloni), Spons Over (30 koloni), dan Sedimentation Demage (64 koloni). Prevalensi penyakit yang ditemukan seperti Skeletal Eroding Band 0,46%, Brown Band Disease 0,93%, White Syndrom 6,48%. Prevalensi gangguan kesehatan karang seperti kerusakan akibat sedimentasi (37,96%) dan Respon Pigmentasi (20,83%). Korelasi antaran tutupan karang hidup, prevalensi dan kelimpahan penyakit karang memiliki korelasi yang erat dengan nilai masing-masing 0,7794 (korelasi persen tutupan dan prevalensi), 0,9139 (kelimpahan dan tutupan karang) dan 0,8658 (prevalensi dan kelimpahan penyakit). Semakin tinggi persen karang hidup maka semakin tinggi penyakit dan gangguan kesehatan karang yang ditemukan.
Extracción optimizada y purificación parcial de invertasa aislada de S. Cerevisiae en puré de durazno
Authors: Ferreira Marcela Vega , Rossler Aline Farias , Toralles Ricardo Peraça , Ruiz Walter Augusto , Rombaldi Cesar Valmor
Published: March 2018

Resumen La extracción fue realizada a través de un proceso de autolisis, donde las enzimas degradan las estructuras celulares y liberan el contenido citoplasmático al medio extracelular. El proceso de autolisis fue realizado en shaker con diferentes velocidades de agitación (50 - 350 rpm) y concentraciones de bicarbonato de sodio (50 -350 mM NaHCO3) a 40 °C por 24 horas, usando un diseño experimental compuesto central adaptado para dos variables y cinco niveles, así como una metodología de superficie de respuest a (MSR) y análisis canónico para definir las condiciones óptimas de extracción de invertasa de S. cerevisiae aislada de puré de durazno (ISc). En la condición optima de extracción, se estudió el efecto de la liofilización y purificación en la actividad de la invertasa, usando el método colorimétrico del ácido 3,5-dinitrosalicílico (DNS) a 490 nm para acompañar su actividad expresada en unidades. Una unidad (U) es definida como 1 mg glucosa.min-1. El valor de proteínas fue cuantificado por el método Lowry y la invertasa de levadura comercial (ILC) como testigo. La influencia de la concentración de NaHCO3 y de la velocidad de agitación en la extracción de la enzima invertasa indicó efecto lineal, cuadrático e interactivo. El modelo de forma polinómica de segundo orden explicó el fenómeno de extracción de la invertasa con un R2 de 0,80, y con actividad significativamente dependiente de ambas variables. La máxima extracción fue observada en el punto central experimental (200 mM NaHCO3 y 200 rpm) con una actividad de 14,7 U.mg-1. El punto estacionario es un punto de máxima extracción, el cual difiere en menos de 10% del punto central experimental. De acuerdo a estas características, las óptimas condiciones para extracción de la invertasa de S. cerevisiae aislada de puré de durazno son 200 mM NaHCO3 como agente de autolisis, 200 rpm de agitación orbital a 40oC durante 24 horas y usando una biomasa de levaduras liofilizadas. El etanol es más efectivo que la acetona para la recuperación de la actividad específica.
FORMAÇÃO DOCENTE PARA EDUCAÇÃO INFANTIL NOS CURRÍCULOS DE PEDAGOGIA
Authors: Albuquerque Moema Helena Koche de , Rocha Eloisa Acires Candal , Buss-Simão Márcia
Published: March 2018

RESUMO: O presente artigo apresenta dados de uma pesquisa que objetivou analisar os currículos dos cursos de Pedagogia das Universidades Públicas Federais no Brasil considerando a promulgação das Diretrizes Curriculares Nacionais para os cursos de Pedagogia em 2005. A análise das configurações curriculares contemplou trinta e três universidades das quarenta e sete que ofereciam o curso de graduação em Pedagogia. A fim de analisar a configuração dos currículos de Pedagogia para a formação específica da docência para a educação infantil, foi preciso dar visibilidade ao lugar que as crianças e a infância ocupam no seu interior. A análise destes conteúdos buscou identificar ainda a existência de diálogos interdisciplinares para tratar da infância e suas consequências para a consolidação conceitual e a orientação das ações pedagógicas com as crianças na educação infantil.
Effects of sugarcane juice addition on the population dynamics of Escherichia coli and the presence of Shiga-toxigenic E. coli during the anaerobic codigestion of dairy cattle manure
Authors: Branco Paula Maria Pilotto , Fernandes Aline , Cangani Max Ternero , Souza-Pollo Andressa de , Lucas Júnior Jorge de , Amaral Luiz Augusto do
Published: March 2018

ABSTRACT: The objective of this study was to evaluate the effects of the addition of sugarcane juice on the population dynamics of Escherichia coli and the presence of Shiga-toxigenic E. coli (STEC) during the anaerobic codigestion of dairy cattle manure. For the overall analyses at the end of a hydraulic retention time of 90 days, ten two-liter batch-type biodigesters were divided into two treatment groups: biodigester containing manure and water (MW) and the biodigester containing manure, water and sugarcane juice (MSC). For monitoring the population dynamics and presence of microorganisms, pH, and volatile acidity, tests were carried out every ten days, on 36 smaller-scale batch biodigesters made of one-liter plastic bottles (18 for each treatment). The reductions in E. coli population over time were significant in the MW (60 days) and MSC (20 days) biodigesters. Inactivation of STEC occurred in a shorter period (40 days in MW and <10 days in MSC). Significant differences were obtained between the two treatments, with the pH values being lower, the concentrations of volatile acids (VA) being higher, and the inactivation of E. coli and STEC being faster in the biodigester with sugarcane juice added. The amount of sugarcane juice applied (7%) suggests its suitability for the sanitization of dairy cattle manure for use as a biofertilizer, given the high reduction in the E. coli population and inactivation of STEC.
JUDICIALIZAÇÃO DA SAÚDE: ACESSO AO TRATAMENTO DE USUÁRIOS COM DIABETES MELLITUS
Authors: Santos Ellen Cristina Barbosa dos , Teixeira Carla Regina de Souza , Zanetti Maria Lúcia , Istilli Plínio Tadeu , Pereira Lúcia Helena Terenciani Rodrigues , Torquato Maria Teresa da Costa Gonçalves
Published: March 2018

RESUMO Objetivo: analisar os elementos processuais e as ações judiciais individuais impetradas por usuários com diabetes mellitus para fornecimento de medicamentos, insumos ou materiais no tratamento da doença. Método: estudo quantitativo exploratório do tipo documental onde foram analisados 636 processos judiciais em uma região do interior paulista, de 2004 a 2013. Resultados: constatou-se que o número de processos é crescente de três em 2004 até 111 em 2012. Em 2013 medidas administrativas foram instituídas com o intuito de reduzir o número de ações. Em 457 (71,9%) processos as ações foram impetradas por meio de prescrição de consultórios médicos particulares. A maioria dos processos judiciais foram solicitações de medicamentos que não constavam nas listas de financiamento gratuito pelo Sistema Único de Saúde. Conclusão: a judicialização à saúde favorece a reflexão sobre os direitos em saúde e o acesso à informação na reestruturação dos serviços de saúde aos usuários com diabetes mellitus.
COMPARAÇÃO ENTRE GRAVIDADE DO PACIENTE E CARGA DE TRABALHO DE ENFERMAGEM ANTES E APÓS A OCORRÊNCIA DE EVENTOS ADVERSOS EM IDOSOS EM CUIDADOS CRÍTICOS
Authors: Toffoletto Maria Cecilia , Oliveira Elaine Machado de , Andolhe Rafaela , Barbosa Ricardo Luis , Padilha Katia Grillo
Published: March 2018

RESUMO Objetivo: comparar a gravidade do paciente e a carga de trabalho de enfermagem antes e após a ocorrência de evento adverso moderado e grave em idosos internados em unidades de terapia intensiva. Método: estudo comparativo, realizado em nove unidades de terapia intensiva de um Hospital Universitário de São Paulo. Os eventos foram coletados dos prontuários dos pacientes e classificados em moderados e graves segundo a Organização Mundial de Saúde. A análise da gravidade foi realizada segundo o Symplified Acute Phsiologic Score II e a carga de trabalho segundo o Nursing Activities Score, 24 horas antes e depois do evento moderado e grave. O teste t, com significância de 5%, foi utilizado para a comparação das médias da gravidade clínica e da carga de trabalho, antes e após o evento. Resultados: a amostra foi composta por 315 idosos, sendo que 94 (29,8%) sofreram eventos moderados e graves nas unidades. Dos 94 eventos, predominou o tipo processo clínico e procedimento (40,0%). A instalação e manutenção de artefatos terapêuticos e cateteres foram as intervenções prevalentes que resultaram em danos fisiopatológicos (66,0%), de grau moderado (76,5%). A média de pontuação da carga de trabalho (75,19%) diminuiu 24 horas após a ocorrência do evento (71,97%, p=0,008) e, a gravidade, representada pela probabilidade de morte, aumentou de 22,0% para 29,0% depois do evento (p=0,045). Conclusão: no contexto da segurança do paciente, a identificação das alterações nas condições clínicas e na carga de trabalho de enfermagem em idosos que sofrem eventos subsidiam a prevenção dessas ocorrências.
Thrips species (Insecta: Thysanoptera) associated with flowers in a restinga fragment in northeastern Brazil
Authors: Lima I. M. B. , Almeida-Filho M. A. , Lima M. G. A. , Bonilla O. H. , Lima E. F. B.
Published: March 2018

Abstract With the growing volume of research involving Thysanoptera in Brazil, studies were carried out to improve our understanding of the diversity of thrips in areas where the fauna has historically been neglected. Accordingly, we recorded the diversity of thrips (Insecta: Thysanoptera) associated with a restinga fragment located on the campus of the State University of Ceará (UECE), Fortaleza, Ceará state, and computed the estimated richness and diversity indices. Samples were collected from 2011 through 2013 from flowers of 86 plant species. The material was taken to the Laboratory of Insect-Plant Interaction, where thrips were screened under stereomicroscope. We collected 456 adults and 58 immatures, representing 14 species, in addition to one unidentified species of Treherniella. Microcephalothrips abdominalis was found on a large number of host plants, and Frankliniella insularis was the most common species. About two-thirds of the total richness of thrips species was associated with three plant families (Amaranthaceae, Caesalpiniaceae and Poaceae); six thrips species were each associated with only one plant species. The richness of the species collected was close to that estimated by Bootstrap and Jackknife 1 analysis. The Shannon-Wiener (H’) and Simpson (D) diversity indexes were 1,7607 and 0.7769, respectively. Although the species are common, 46 new associations between plant species and thrips were established, 13 of which are true host associations, which demonstrates the importance of coastal vegetation in maintaining populations of thrips.
Responses of antioxidant enzymes, photosynthetic pigments and carbohydrates in micropropagated Pitcairnia encholirioides L.B. Sm. (Bromeliaceae) under ex vitro water deficit and after rehydration
Authors: Resende C. F. , Pacheco V. S. , Dornellas F. F. , Oliveira A. M. S. , Freitas J. C. E. , Peixoto P. H. P.
Published: March 2018

Abstract In this study, the activities of antioxidant enzymes, photosynthetic pigments, proline and carbohydrate contents in Pitcairnia encholirioides under ex vitro conditions of water deficit were evaluated. Results show that plants under progressive water stress, previously in vitro cultured in media supplemented with 30 g L-1 sucrose and GA3, accumulated more proline and increased peroxidase (POD) activity and the contents of photosynthetic pigments and carbohydrates. For plants previously in vitro cultured with 15 g L-1 sucrose and NAA, no differences were found for proline content and there were reductions in activities of peroxidase (POD), catalase (CAT) and poliphenoloxidase (PPO), and in contents of carbohydrates, with progress of ex vitro water deficit. After rehydration, plants showed physiological recovery, with enzymatic activities and contents of metabolites similar to those found in the controls not submitted to dehydration, regardless of the previous in vitro culture conditions. These results show that micropropagated P. encholirioides has high tolerance to dehydration once in ex vitro conditions, which can ensure the survival of plants from tissue culture when transferred to its natural environment, emphasizing the importance of such biotechnology for the propagation of endangered species.
Using anonymous probe-vehicle data for a performance indicator of bridge service
Authors: Bechtel Andrew J , Brennan Thomas M , Gurski Kevin , Ansley Jessica
Published: March 2018

Anonymous probe-vehicle data are being used to evaluate travel time reliability and congestion conditions along roadways. These telematics data are collected from commercial and private cell phones, global positioning system devices and on-board vehicles computers. In the last few years, these data have been incorporated into reports of highway and arterial systems to measure congestion conditions. For this paper, anonymous probe-vehicle data were used to calculate a congestion metric, at bridge locations in New Jersey, USA, based on aggregated yearly congestion hours. The congestion metric was then compared to the functionally obsolete (FO) performance designation defined by the US National Bridge Inventory (NBI). These FO bridges represent structures that, according to the NBI, theoretically cause congestion. The comparison showed that the FO designation did not indicate high levels of congestion and vice versa. Consequently, when the congestion metric was implemented in a rudimentary management strategy, it provided a clearer decision-making process over the current traffic carrying metric in the NBI. The results of this study show that the aggregated congestion metric can serve as a useful performance indicator for bridge structures at a regional level, and it can provide value when incorporated into a bridge asset management programme.
Thermally stable antibacterial wool fabrics surface-decorated by TiON and TiON/Cu thin films
Authors: Sadeghi-Kiakhani Mousa , Khamseh Sara , Rafie Akbar , Tekieh Seyed Mohsen Fatemi , Zarrintaj Payam , Saeb Mohammad Reza
Published: March 2018

Owing to the enormous production and various applications of wool, its modification has attracted increased attention. Nowadays, antibacterial properties are essentially of premier importance; hence, there has been an increasing interest in antibacterial wool fabrics in recent years, but the inadequate thermal stability of wool fabrics has limited their use for high-quality applications. Meanwhile, surface treatment of wool fabrics has become a solution to thermal and antibacterial shortcomings. In the present work, wool fabrics sputter-deposited by titanium oxynitride (TiON) and titanium oxynitride/copper (Cu) thin films are discussed. The microstructure of thin films was characterized by scanning electron and atomic force microscopies, contact angle and antibacterial analyses. The contact angle and thermal stability of wool fabrics decorated by titanium oxynitride were limitedly enhanced, while the antibacterial activity was significantly improved, as shown by c. 90% deleterious effect against Escherichia coli, but copper addition to titanium oxynitride resulted in c. 100% bacteria obliteration. Moreover, the increase of the copper content in titanium oxynitride/copper coating decreased water contact angle, while the thermal stability and antibacterial activity were enhanced. It was found that it is possible to regulate the hydrophobicity, thermal stability and antibacterial activities of wool fabrics sputter-coated with titanium oxynitride/copper, paving the way for expanding wool fabric as an eco-friendly substance.
Superhydrophobic, superoleophobic and underwater superoleophobic conducting polymer films
Authors: Darmanin Thierry , Godeau Guilhem , Guittard Frédéric
Published: March 2018

From a bioinspired approach, this review reports most of the techniques used in the literature to prepare superhydrophobic, superoleophobic and underwater superoleophobic films using conducting polymers. These techniques include the formation of conducting polymer nanostructures by oxidative chemical polymerization, chemical vapor deposition, plasma deposition and electrodeposition (pre- and post-approaches). Template and templateless electrode positions are also reported. Compared to other materials, conducting polymers have unique optoelectronic properties making them sensitive to various stimuli and have, for example, very interesting applications in optical devices, sensors and oil/water separation membranes.
Indicadores de Sustentabilidade Ambiental na Universidade do Estado de Santa Catarina
Authors: De Almeida Gomes Gilmar , Karoline Cherobin Ana
Published: March 2018

A introdução de questões ambientais nas universidades, surgiu com elevada importância para o tema educação ambiental. A necessidade de formar pessoas, profissionais com uma visão e uma condução ambiental mais abrangente é um fator de extrema importância para o desenvolvimento de uma sociedade sustentável. Este trabalho buscou mostrar a inserção de indicadores de sustentabilidade na Universidade do Estado de Santa Catarina(UDESC). A pesquisa foi realizada no segundo semestre de 2016 e primeiro semestre de 2017, utilizou-se a base de dados da universidade, onde foram avaliadas as atividades de ensino, pesquisa e extensão realizadas na universidade, com esses resultados interpretou-se os valores para cada campus da UDESC. Para o campus III, notou-se uma maior presença de indicadores de sustentabilidade nas atividades realizadas na universidade. Já os outros campus apresentaram estes indicadores, mas em quantidades menores se comparado ao campus III. De um modo geral foi verificado uma quantidade de ações de sustentabilidade em ensino, pesquisa e extensão, distribuída em todos os campis

PALAVRAS-CHAVES: Indicadores de sustentabilidade. Meio Ambiente.
Avaliação do Impacto Ambiental Utilizando Ferramentas Físico-Químicas
Authors: Gomes Gilmar de Almeida , Franchini Carolina , Zambiasi Eliziane
Published: March 2018

Em vista dos problemas atuais relacionados a água própria para consumo humano, é necessário avaliar e preservar os recursos hídricos disponíveis. Este artigo apresenta os resultados de análises físico-químicas (cloreto, dureza, alcalinidade e pH) para os rios Lajeado Bonito e Limeira da cidade de Pinhalzinho, Oeste de Santa Catarina e também os cálculos de Energia de Gibbs para cada ponto avaliado. Também foram comparados os resultados obtidos com os anteriores de 2015. Notou-se uma piora em relação a maioria dos pontos para os dois rios, indicando uma maior ação antropogênica sobre eles. Houve aumento principalmente no teor de cloreto dos dois rios, indicando maior carga de esgotos domésticos lançados nestes pontos. Ocorreu variação na Energia de Gibbs para todos os pontos. Quanto menor a Energia de Gibbs, mais estável é o sistema, mas essa estabilidade do sistema vem à custa de uma vizinhança com maior energia para evitar o desequilíbrio ambiental.

PALAVRAS-CHAVE: Rio Lajeado Bonito. Rio Limeira.Íons.