bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Environmental Factors on Rhinosinusal Tumours
Authors: Hainarosie Razvan , Domuta Eugenia Maria , Tusaliu Mihail , Dabija Marius Gabriel , Anghelina Florin , Radeanu Doinel , Palade Octavian Dragos
Published: January 2020

Cancer of the nasal cavity and paranasal sinuses is a rare malignancy. The tumours of the nasal cavity are thus associated with the maxillary and ethmoidal sinuses. Those that start from the nasal vestibule and nasal septum raise particular problems and, although rare, form a particular group of cases among the rhinosinusal tumours. Radiation exposure, viral infections and constitutional factors were associated with the occurrence of rhinosinusal neoplasia also, but the evidence is inconclusive and indicates that only a small proportion of all squamous carcinomas can be attributed. The purpose of this study is the complex retrospective analysis of the cases of rhinosinusal malignancies diagnosed and treated in the Otolaryngology Clinic of the St. Spiridon Emergency Clinical Hospital in Iasi. We evaluated the characteristics of the patient group using a statistically significant analysis of the age, gender, background, and factors of affiliation. Specific tests and indicators have been used. It is not to be neglected the effects of the poor economic conditions andthe lack of education of the population, by postponing the moment of presentation tophysician, influencing the therapeutic decision, postoperative evolution. Thesepatients often present different degrees of malnutrition,immunodepression, etc. Statistical processing showed that thesepatients have a twofold risk of developing rhinosinusal tumours.
Possible Retard in the Language Development to the Children Born through IVF (In Vitro Fertilisation)
Authors: Nedelcuta Ramona , Baleanu Vlad Dumitru , Ciora Cosmin , Calin Gigi , Stanescu Mihail-Relu , Davitoiu Dragos Virgil , Tenea-Cojan Tiberiu Stefanita , Socea Bogdan , Voiculescu Daniel-Iulian , Alexandru Dragos Ovidiu , Stanescu Radu
Published: January 2020

Research in recent years on a possible and evident pathology, appeared in children s case from pregnancies obtained through in vitro fertilization (IVF), did not show significant differences than the children born from pregnancies obtained naturally. Having a good start in life, the consignments studied were feed exclusively in a natural way in the first 6 months, knowing the complex role of breast milk, including nerve growth. The delay in language development has shown significant differences between the IVF consignment and the control group and the pathology exam a possible involvement in cerebral embryogenesis, especially the Broca s area, of some disturbing factors, with a maximum of action before the 23rd week.
Absorption of Sulfur Dioxide in Water with High Salinity
Authors: Pincovschi Irina , Modrogan Cristina
Published: January 2020

Understanding the absorption behaviour of sulphur dioxide in aqueous electrolyte solutions is of major interest for the design of flue gas desulphurization processes, as for example wet flue gas desulphurization of coal fired power plants or municipal solid waste incineration plants. In the present paper the influence of the water salinity on SO2 absorption is studied. The SO2 absortion was performed in equilibrium condition. The variation of marine solubility from 10 g/L to 40 g/L determines the variation of SO2 concentration in water from 2.6 mol/L to about 3.2 mol/L. In consequence, the variation of water salinity in these limits can detemine a quite big difference of water pollution.
On Thermodynamic Possibility of Retort Steel Components Interaction with Titanium Chlorides and Oxygen During Kroll Process
Authors: Chervonyj Ivan , Listopad Dmytro , Gab Angelina , Malyshev Victor , Neacsu Elena Ionela , Donath Cristina , Cosntantin Virgil , Popescu Ana-Maria
Published: January 2020

Thermodynamic analysis was carried out of the possible effects of interaction reactions of the main components of the metallic retort (Fe, Ni, Cr, Mn) with titanium chlorides and with oxygen, during magnesium thermal method of titanium obtaining. The temperature dependences of DG for the conversion of metals into their chlorides and oxides allowed to establishe the temperature ranges in which the above reactions take place.
Analysis of Stress and Prediction of the Defects of an Ankle Prosthesis Using the Autodesk Inventor Software
Authors: Popescu Stefan-Catalin
Published: January 2020

The paper presents stress analysis of an ankle prosthesis and the prediction of the cracks appearance that may occur using the finite element method. The first test was performed using as material for the ankle prosthesis simulation, aluminium alloy 6061, and in the second test were use titanium as the simulation material. Von Mises�s basic concept, failure theory, is also analysed, using Autodesk Inventor simulation software, in an attempt to give a perspective on the material from which the ankle prosthesis must be made. In conclusions were presented results for stress, endurance, and safety factors for simulated prosthesis.
Advanced Micro-chemical Investigation of Golden Threads from Romanian Byzantine Embroideries by Micro-Particle Induced X-ray Emission (micro-PIXE)
Authors: Balta Zizi Ileana , Demetrescu Ioana , Petroviciu Irina , Lupu Mihai
Published: January 2020

In the present study, golden threads from two, apparently identical, medieval epitrachelions considered masterpieces of the Romanian Byzantine embroidery art, were investigated by using Micro-Particle Induced X-ray Emission (micro-PIXE) and optical microscopy. PIXE measurements allowed to accurate identify the elemental composition, distribution of the trace elements, the layered structures (depth profiling) and thicknesses of the gold layer. Useful information for the characterization of the gilded silver threads due to elemental maps concerning the constituent elements spatial distribution in the sample was also obtained.
New Various Histopathological Findings of the Placenta in Preeclampsia
Authors: Luchian Ioan-Bogdan , Nada Elena-Silvia , Dumitru Vasile-Adrian , Albu Dinu-Florin , Patrascu Anca , Goganau Alexandru Marian , Albu Stefan-Dimitrie , Albu Cristina-Crenguta
Published: January 2020

Preeclampsia represents a pregnancy-related disease which affects both the mother and the fetus. It�s an important cause of materno-fetal morbidity and mortality. The placenta seems to be the main cause because after placental removal preeclampsia is no longer present. Placental examination is crucial and can reveal important information about this disease. After careful examination, besides the classic findings, new and uncommon histopathological aspects of the placenta in preeclampsia were described. A short observational study was performed which included placentas from preeclampsia complicated pregnancies. The various histopathological findings of the placenta in preeclampsia were evaluated according to gestational age.
Synthesis and Antimicrobial Assessment of Some New 2-(Thiazol-5-yl)-1,3,4-oxadiazoles
Authors: Araniciu Catalin , Oniga Smaranda Dafina , Stoica Cristina Ioana , Chifiriuc Mariana Carmen , Popa Marcela , Vlase Laurian , Palage Mariana , Oniga Ovidiu
Published: January 2020

Considering the promising antimicrobial activity of compounds bearing the thiazole or the oxadiazole rings in their structures, we set out to obtain new antimicrobial molecules bearing the 2-(thiazol-5-yl)-1,3,4-oxadiazole schaffold. The structures of the 8 new compounds obtained was confirmed by physicochemical characterization including: 1H-NMR, MS and elemental analysis. Antimicrobial activity was investigated against 5 Gram-positive bacterial strains, 2 Gram-negative bacterial strains and 2 fungal strains. The newly synthesized compounds showed modest antimicrobial activity.
Structural and Magnetic Properties of La0.9Sr0.1MnO3 Nanoparticles Prepared via Sol-gel Process
Authors: Marincas Alexandru-Horatiu , Goga Firuta , Dudric Roxana , Suciu Crina , Avram Alexandra , Dorneanu Sorin Aurel , Ilea Petru
Published: January 2020

In the present paper, nanosized La0.9Sr0.1MnO3 particles were synthesized via a facile modified sol-gel route using two cheap and environmentally friendly organic chemicals, namely sucrose and pectin. The obtained powders were characterized by thermo gravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), and magnetic measurements. The optimal temperature for obtaining nanosized particles was determined as 1000�C and 1h dwell time was enough to obtain crystalline nanoparticles. Magnetic properties of samples calcined with different calcination period were analyzed and both samples shown a transition temperature around 274 K.
Renewable Energy Production Potential by using from Wastes Generated in a Pigs Farm and Slaughterhouse
Authors: Fregue Rufis Tagne Tiegam , Wachter Adriana Raluca , Ionel Ioana , Vintila Teodor , Julean Calin , Moisa Sebastian , Ungureanu Claudiu Ion , Mihaiuti Alin Cristian
Published: January 2020

Biogas produced from wastes is regarded as advanced biofuel and is under current EU regulation, promoting the growth of advanced biofuels. In this study, the authors focused the research on the potential of a pig farm and an adjacent slaughterhouse and meat processing enterprise to produce not only meat, but energy as well, through anaerobic digestion of wastes produced during current activities to produce biogas as energy carrier. One had assessed the potential of a pig�s farm and an adjacent slaughterhouse and meat processing enterprise to produce biogas as energy carrier, using anaerobic digestion of wastes generated in production activity. All experiments were carried out on a performing lab device. The results indicate solid sludge and fats resulted from slaughterhouse are capable to produce high yields of methane, reported to dry organic matter. Although organic wastes resulted from slaughterhouse can generate high quantities of methane by anaerobic digestion, large quantities of organic wastes are generated in the assessed pig�s farm and the potential for energy production is much higher in the case considering as source the pig�s farm than slaughterhouse. Finally, one demonstrated that by combining organic wastes generated in the pig�s farm with the organic wastes resulted from slaughterhouse, or organic wastes generated in the pig�s farm with the biomass produced on 200 hectares of triticale as short rotation crop, one can supply the energy source, necessary to operate an one-megawatt installed power biogas plant.
Cadmium Content and Accumulation in Lettuce Grown on Different Types of Soil
Authors: Boskovic-Rakocevic Ljiljana , Pavlovic Rados , Duric Milena , Pavlovic Milan
Published: January 2020

This study was conducted on a pseudogley (pH 5.0) and a vertisol (pH 6.9) to analyze their total and available Cd levels and Cd accumulation by lettuce for risk assessment of potential human health impacts. Total Cd levels in both soil types were below maximum allowable concentrations, and showed a high dependence on soil pH (R=-0.974). Monoammonium phosphate (MAP) fertilizers containing various amounts of cadmium led to an increase in cadmium uptake, with higher concentrations accumulated in lettuce roots than in leaves. The transfer factor showed that Cd uptake from the pseudogley was much higher than from the vertisol, and its values indicated that lettuce is a cadmium hyperaccumulator. Lettuce head weight decreased with increasing cadmium rates and was highly negatively correlated with Cd concentration in the leaves (R=-0.818).
Severity of Psoriasis Associated with Metabolic Syndrome
Authors: Stanescu Ana Maria Alexandra , Stefani Constantin , Grajdeanu Ioana Veronica , Serban Bogdan , Ciobanu Gheorghe , Diaconu Camelia Cristina
Published: January 2020

Although extensively studied, psoriasis still has negative consequences and is associated with multiple comorbidities, including metabolic syndrome. The severity of psoriasis seems to influence the occurrence of diagnostic criteria for metabolic syndrome. 208 patients diagnosed with psoriasis were identified, who were divided into lots depending on the severity of psoriasis, but also to the presence or absence of metabolic syndrome. Interpretation of statistical data was done with SPSS V21 (Statistical Package for Social Science) and MEDCALC (Statistical Software). The coexistence of severe psoriasis with metabolic syndrome increases the risk of developing cardiovascular diseases by 2.97 or greater, with a confidence interval of [1.60, 5.51], than that of patients with severe psoriasis who have no metabolic syndrome. The hypothesis was statistically confirmed by p = 0.003. Analyzing the total group with psoriasis by severity, we found the following distribution: from the total number of 208 patients, 39 (18.8%) had severe psoriasis, 83 (39.9%) moderate psoriasis and 86 (41.3%) mild psoriasis. The higher incidence of metabolic syndrome in patients with psoriasis is evidenced by the Pearson Chi-Square test, where p [0.001. The association of metabolic syndrome in patients with psoriasis is evident. The more severe the psoriasis, the more likely it is to develop metabolic syndrome.
Metabolic Syndrome Among Patients with Rheumatoid Arthritis and the Correlation with Disease Activity
Authors: Ene Cristina Gabriela , Mitroi Mihaela , Vladu Ionela Mihaela , Radu Lucretiu , Tenea Cojan Tiberiu Stefanita , Predescu Anca Mihaela , Bunescu Marius Gabriel
Published: January 2020

Rheumatoid arthritis is a systemic inflamatory disease that affects primarily the synovial joints and it is associated with a progressive disability and a important socio-economic burden. [1] Although the main characteristic is the joint involvement, it is important to remember that RA is a disorder with systemic involvement mainly due to it�s chronic inflamation. Patients with RA have a higher risk of cardio-vascular mortality that in general population. There are numerous studies that sugest that inflamation plays a key�role in the develompent of aterosclerosis and heart disease, therefore a better understanding of the inflamatory response in RA may lead to better outcomes for patients with RA. Metabolic Syndrome is described as a congregate of major risk factors for cardiovascular diseases (CVD): Diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood presure[2]. The clustering of CVD risk factors that typifies the metabolic syndrome is now considered to be the driving force for a new CVD epidemic [3]. The conducted study aims to assess and evaluate the presence of metabolic syndrome (MetS) in RA patients. 120 patients with RA (89 women and 31 men) and 120 (85 women and 35 men) patients without RA were included in the study. The prevalence of MetS in RA patients was 39.16% and 22.5% for the control group. RA patients with MetS had significantly higher disease activity score of 28 joints index (DAS28-ESR) than patients without MetS ( 3.70 � 0.644 vs. 3.35 �0.725; p=0.006).
Influence of Fine Bubble Generator Architecture on Time Variation of Dissolved Oxygen Concentration in Water
Authors: Baran Nicolae , Constantin Mihaela , Tanase Beatrice , Moraru Edgar , Moga Corina Ioana
Published: January 2020

The paper presents two constructive solutions in the field of fine bubble generators that serve to aerate the water. Two installations for experimental researches have been designed and built in connection with the two constructive solutions. The dissolved oxygen concentration was experimentally determined. The theoretical and experimental results for the two constructive solutions are compared showing a good coincidence in relation to the results reported in the literature.
Evaluation of Phenolic Compounds Content and Antioxidant Capacity of Some Medicinal Plants, Potentially Used for Their Preventive Role Against Various Oral Diseases
Authors: Ciavoi Gabriela , Jurca Tunde , Pasca Bianca , Bechir Edwin Sever , Mraz Camelia , Jurca Claudia , Kiss Rita , Marc Felicia , Pallag Annamaria
Published: January 2020

The oral cavity diseases represent a public health issue. Antioxidants have an important role in the prevention of these diseases. In this study we tested different types of plants in order to evaluate the compounds with antioxidant capacity and in order to create a topical product which prevents oral cavity diseases. Phenolic compounds and flavonoids were analyzed in four different species of medicinal plants from spontaneous flora of Bihor County. The antioxidant capacity of the extracts was evaluated by: CUPRAC assay, ABTS method and FRAP method. Our results show that the studied medicinal plants represent rich sources of compounds with antioxidant capacity, especially Polygonum aviculare and Fumaria officinalis.
Nicotine Addiction : Objective in Educational Programs for Smoking Prevention in Young People
Authors: Budin Corina Eugenia , Alexescu Teodora Gabriela , Bordea Ioana Roxana , Gherginescu Mircea Constantin , Aluas Maria , Grigorescu Bianca Liana , Biro Levente , Buzoianu Anca Dana , Nemes Roxana Maria , Tantu Monica Marilena , Todea Doina Adina
Published: January 2020

In those countries where education and smoking prevention campaigns are carried out at school level, there has been a decline in the prevalence of smoking among pupils. Nicotine addiction represents a sum of pharmacological, electrophysiological and molecular genetic mechanisms and behavior patterns. The study was conducted from December 2016, to July 2017 and it consisted in an online survey posted on a website. The participants accessed the survey through an e mail link. The study population consisted of 1144 teachers (from primary school, gymnasium and college). The declared percentage of daily smokers was 14%, below the European average, while 20.5% were declared ex-smokers, 11.2% were occasional smokers and 54.4% never smoked. The theme of smoking was approached by 79.2% of teachers during conducting classes and 81.6% of them advised smokers to stop smoking. Teachers can influence the pupils� behavior by personal example and by teaching, inside and outside the school, thus preventing nicotine addiction. Decreasing the prevalence of smoking among teachers will inevitably lead in the future to a decrease of adolescent smokers� incidence. Our study was a pilot project that can draw important directions in educational and preventive campaigns in schools.
Portal Vein Thrombosis and Gut Microbiota: Understanding the Burden
Authors: Georgescu Doina , Iurciuc Mircea , Ionita Ioana , Georgescu Liviu-Andrei , Muntean Mihaela , Lascu Ana , Ionita Mihai , Lighezan Daniel
Published: January 2020

Portal vein thrombosis (PVT) continues to be challenging, due to its versatile features and associated clinical pitfalls. This study aimed to explore whether gut microbiota imbalance (GMI) could alter clinical presentation and short term outcome in cirrhotic patients with PVT. We conducted a cross-sectional exploratory study, concerning 50 consecutive cirrhotic patients with PVT recruited during hospitalization. Consecutive to stool microbiological exams, they were assigned into two groups: 25 GMI positive as study group and 25 GMI negative as comparison group. Clinical examination, laboratory work�ups, upper and lower digestive endoscopy, abdominal Duplex ultrasound and CT/MRI were performed Results: Study group displayed significant differences concerning age, interleukin-10 and albumin levels, digestive bleeding, abdominal pain severity and longer hospitalization. In conclusion, dysbiotic patients displayed clinical particularities characterized by older age, higher inflammatory status, hypoalbuminemia, more severe PVT, abdominal pain and digestive bleeding, as well as longer hospitalization duration.
Immunohistochemical Study of Cell Proliferation in Hepatocellular Carcinoma
Authors: Goldis Adrian , Goldis Ramona , Cornianu Marioara , Basa Norina , Lazar Daniela , Dobrescu Amadeus , Lazar Fulger
Published: January 2020

Hepatocellular carcinoma (HCC), the most common primary liver cancer, with a poor prognosis, is the fifth most common cancer in men and the seventh in women. The study was made on 32 surgically removed liver carcinomas. In order to compare results, we included a group of non-tumor lesions obtained by liver biopsy. Assessment of the proliferative activity of the studied liver lesions was made using immunohistochemical stains with the monoclonal Ki-67 antibody, clone MIB-1 ready-to-use (DAKO Cytomation CA, USA), in the LSAB-HRP work system. To appreciate the proliferation index of Ki-67 (PI Ki-67), we used the semi-automated method of counting the nuclei on digital images. The statistical analysis was performed using SPSS software, Version 20.0 (IBM SPSS Statistics) and Microsoft Office Excel 2007. Mean value of Ki-67 index was 0.4 � 0.2 in normal liver, 3.52 � 0.2 in non-tumor liver lesions and 13.4�7.7 in HCC (p [ 0.001). In chronic hepatitis, PI Ki-67 varied between 2.5 and 5.8 %, with a mean value of 5.2% in portal chronic hepatitis and 5.5% in active chronic hepatitis with cirrhotic evolution. In HCC, the values of Ki-67 index were between 0.7% and 52%, with a mean of PI Ki-67 of 13.43�7.7. 66.6% of HCC associated with hepatitis B virus infection and those developped from a cirrhotic lesion had a high Ki-67 score (p = 0.1). The results we obtained showed: a low Ki-67 score in patients with well-differentiated HCC (G1) (p[0.001), with or without capsule infiltration (p = 0.003); high PI Ki-67 in 33.33% of HCC detected in the right hepatic lobe and those extended bilaterally at the moment of diagnosis (p = 0.142) and a significant relationship between high Ki-67 score and vascular invasion (p [ 0.001), the presence of intrahepatic metastasis being correlated with a high proliferative rate (p [ 0.001). Differences between the proliferation rate of HCC and non-tumor liver lesions (p [ 0.001) show that the uncontrolled division of tumor cells can play an important role in the developpment of HCC.
Preliminary Study on the Correlations Between Oxytocin Levels and Irritable Bowel Syndrome in Patients with Depression
Authors: Gavril Raluca , Hritcu Luminita , Padurariu Manuela , Ciobica Alin , Horhogea Cristina , Stefanescu Gabriela , Spataru Mihaela Claudia , Straulea Crina , Stefanescu Cristinel
Published: January 2020

Lately there are increased evidences that oxytocin may be an important mediator in several psychiatric disorders including depression and anxiety. Oxytocin system seems to be linked with several neurotransmitters important in psychiatric disorder, but also with the hypothalamic�pituitary�adrenal (HPA) axis and is also a key factor in stress regulation mechanisms. Considering the oxytocin receptor pattern of distribution both central and peripherally and the growing data concerning the disbalance of oxytocin in psychiatric disorders we may speculate that oxytocin system may be at the core of psychosomatic disturbances. Also, recent data brought to attention that oxytocin receptor is distributed throughout gastrointestinal tract. Our hypothesis of the present study was that oxytocin system is disbalanced in irritable bowel syndrome considering also the psychological component of this digestive disorder. We preliminary report here a significant decrease of serum oxytocin levels in patients with major depression disorder and irritable bowel syndrome, as compared with those with major depression disorder alone.
Undesirable Effects of Some Topical Antiseptics Chemical, pharmacological and dermatological aspects
Authors: Tatu Alin L. , Ardeleanu Valeriu , Elisei Alina M. , Dumitriu Buzia Olimpia , Miulescu Magdalena , Nwabudike Lawrence C.
Published: January 2020

Topical antiseptics are a diverse group of agents that are widely used in medicine for the antimicrobial properties. Despite their long history and broad application, caution must be exercised in their use, especially in the pediatric age group, as various cutaneous reactions ranging from hypersensitivity to urticarial to skin necrosis have been reported. The use of topical antiseptics in pediatrics has also been associated with systemic reactions, which depend on the antiseptic in question. Antiseptics such as chlorhexidine, povidon iodine, methylene blue, gentian violet, silver nitrate, boric acid, Castellani solution, alcohol and chloramines have been reviewed. It is essential that physicians bear in mind the possible adverse effects that may follow topical antiseptic use, as this facilitates prevention and also timely intervention if, and when, they occur.
Comparative Study on Minerals in Peel and Pulp of Peach (Prunus persica L.) Fruit
Authors: Mitic Snezana , Stojanovic Branka , Tosic Snezana , Pavlovic Aleksandra , Kostic Danijela , Mitic Milan
Published: January 2020

In this study, variations of minerals contents between peel and pulp parts of six different peach varieties originated from Serbia were investigated by using inductively coupled plasma optical emission spectrophotometry and one-way analysis of variance (ANOVA) with Tukey�s post-hoc test. The content of fifteen elements was determined and content of K was highest among macroelements and Fe among microelements in both parts of the peach fruit. Also, peach peel had higher levels of all minerals with the exception of K. Greater differences between the peel and the pulp and the same parts of different types of peaches are observed in the case of macroelements than the microelements. Hg and Cd are not detected while the contents of Pb and As are below prescribed values.
Attempts to Upcycle PET Wastes into Bio-based Long-lasting Insulating Materials
Authors: Duldner Monica-Mirela , Bartha Emeric , Capitanu Stanca , Nica Simona , Coman Alina Elena , Tincu Robert , Sarbu Andrei , Filip Petru Ivan , Apostol Steluta , Gare Sorina
Published: January 2020

Following the green chemistry principles, three series of polyols with tailored chemical structures were obtained from PET wastes degradation via glycolysis and/or aminolysis and subsequent esterification-transesterification and/or amidation reactions, using an organic catalyst. As cleaving agents there were used various mixtures of renewable or potentially renewable reagents, selected from those that can be obtained from biomass by already applied or investigated and eventually patented biochemical and/or chemical processes. The polyols were characterized by physical-chemical methods, 1H-NMR, 13C-NMR and FT-IR Spectroscopy, and tested in the synthesis of rigid polyurethane foams, showing appropriate properties for spray foams formation and leading to materials with properties similar to conventional spray foams.
As(III) Removal by Dynamic Adsorption onto Amberlite XAD7 Functionalized with Crown Ether and Doped with Fe(III) Ions
Authors: Ciopec Mihaela , Negrea Adina , Duteanu Narcis , Davidescu Corneliu Mircea , Hulka Iosif , Motoc Marilena , Negrea Petru , Grad Oana , Vaduva Delia Berceanu
Published: January 2020

Arsenic content in groundwater�s present a wide range of concentration, ranging from hundreds of micrograms to thousands of micrograms of arsenic per litter, while the maximum permitted arsenic concentration established by World Health Organization (WHO) is 10 mg L-1. According to the WHO all people, regardless of their stage of development and their social economic condition, have the right to have access to adequate drinking water. The most efficient and economic technique used for arsenic removal is represented by adsorption. In order to make this remediation technique more affordable and environmentally friendly is important to new materials with advance adsorbent properties. Novelty of present paper is represented by the usage of a new adsorbent material obtained by physical - chemical modification of Amberlite XAD polymers using crown ethers followed by iron doping, due to well-known affinity of arsenic for iron ions. Present paper aims to test the obtained modified Amberlite polymer for arsenic removal from real groundwater by using adsorption in a fixed bed column, establishing in this way a mechanism for the adsorption process. During experimental work was studied the influence of competing ions from real water into the arsenic adsorption process.
New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity
Authors: Araniciu Catalin , Oniga Smaranda Dafina , Benedec Daniela , Crisan Ovidiu , Vlase Laurian , Palage Mariana , Oniga Ovidiu
Published: January 2020

In an effort to obtain new NSAIDs, that act as COX-2 selective inhibitors with simultaneous iNOS inhibition properties and direct antioxidant activity, we designed a series of 8 new compounds bearing the 5-thiazolyl-carbohydrazon-N-allyl-thiazoline scaffold. The synthesized compounds were physicochemically characterized by: 1H-NMR, MS and elemental analysis. An initial, in vitro, free radical scavenging assay (DPPH bleaching) test showed that most compounds are superior to standard antioxidants Trolox and BHT.
Evaluation of Effectiveness and Tolerability of Boric Acid in the Treatment of Vaginal Infection with Candida Species
Authors: Mehedintu Claudia , Bratila Elvira , Cirstoiu Monica , Petca Aida , Brinduse Lacramioara Aurelia , Berceanu Costin , Barac Ramona Ileana , Andreescu Cristina Veronica , Petca Razvan Cosmin , Sandru Florica , Ionescu Oana Maria
Published: January 2020

Vulvovaginal candidiasis is the most prevalent vaginal infection worldwide. Considering the violence of the symptoms that some patients report, the tendency to relapse or of resistance to the azole therapy, and the success reported by some studies in the treatment with boric acid of the vaginal infection with various pathogens, we conducted a prospective study in which we used vaginal boric acid for Candida species infection. The aim of our study was to evaluate the effectiveness and tolerability of boric acid in the treatment of vaginal infection with Candida species. Analysing the data from the satisfaction questionnaire completed by the patients who reached the end of the study showed that our investigational product has a good and very good effectiveness in sterilizing the infection (71%), being considered by patients to be easily administered (67.7%), the safety of the product being perceived as good and very good by 93.6% of them.
Serum Interleukin 4 and 6 Levels Measured Using the ELISA Method in Patients with Acquired Bronchiectasis Compared to Healthy Subjects. An anti-inflammatory and pro-inflammatory relation
Authors: Lesan Andrei , Man Milena Adina , Nemes Roxana Maria , Harsovescu Tudor , Tudorache Ioan Sorin , Boca Beatrice Mahler , Pop Carmen Monica
Published: January 2020

Evaluation of the inflammatory response based on the Interleukin 4 and Interleukin 6 levels in patients with acquired bronchiectasis (non-cystic fibrosis) and healthy controls. The study was conducted on a group of 77 subjects, divided into 2 lots: the first lot consisting of 57 patients with acquired bronchiectasis objectified by Computed Tomography and 20 healthy individuals. The serum Interleukins 4 and 6 levels were measured using the ELISA biochemical spectrophotometry test. The results are significant from a statistical point of view, especially when it comes to the mean value of Interleukin 4 that was much higher in the control lot. Interleukin 4 is a proinflammatory cytokine and therefore we can draw the conclusion that to some extent bronchiectasis can be associated with an immunodeficiency disorder prior to the pathology itself or it can be caused by the pathology. Future research is open in this field for the analysis of interleukin levels in bronchioloalveolar lavage compared to serum levels.
The Relationship between the Acute Confusing State and the Comorbidities of the Elderly Patient
Authors: Albu Valeria Carmen , Sandu Raluca Elena , Barbulescu Andreea Lili , Tartea Elena-Anca , Burada Emilia , Taisescu Oana , Vreju Florentin Ananu , Boldeanu Mihai Virgil , Boldeanu Lidia , Enescu Aurelia , Pascoveanu Denisa , Stoian Andreea Cristina , Catalin Bogdan , Musatescu Anca Emanuela
Published: January 2020

The aim of the study was to assess the correlations between the acute confusing syndrome and different comorbidities found in a group of 126 elderly patients with this diagnosis, who were admitted to the Neurology Clinic of the Neuropsychiatry Hospital of Craiova. The main syndromes highlighted at the neurological examination were confusing, pyramidal and vestibular syndromes. The acute confusing syndrome has a multifactorial etiology, due to the wide range of comorbidities encountered in elderly patients. In our study the most frequent comorbidities were cardiovascular pathology, diabetes mellitus, dyslipidemia, cerebrovascular renal, hepatic pathology.
Magnetic Nanoparticles (MNPs) Influence on SK-BR3 Breast Cancer Cell Line - in vitro Study
Authors: Iman Vlad , Taculescu Alina , Dehelean Cristina , Paunescu Virgil
Published: January 2020

Nanotechnologies involving the use of magnetic nanoparticles made of nickel, iron or cobalt are nowadays developing in anti-tumor therapy and diagnostic. The most important potential of MNPs is for drug delivery, meaning they are functionalized by binding to chemotherapeutic agents, nucleic acids, antibodies, etc. The present study is questioning the possibility of oleic acid-coated iron MNPs to induce cell death per se, selectively in tumor cells (breast cancer adenocarcinoma SK-BR3 cell line) without previous coupling with effector substances.
Multiple Fatal Intoxications Caused by Improper Consumption of an Alcoholic Para-Pharmaceutical Product
Authors: Buhas Camelia Liana , Buhas Bogdan Adrian , Daina Lucia Georgeta , Hanganu Bianca , Manoilescu Irina Smaranda , Judea Pusta Claudia Teodora , Hlescu Andreea Alexandra , Mircea Cornelia , Somlea Mihaela Cristina , Marian Paula , Ioan Beatrice Gabriela
Published: January 2020

Ingestion of cheap para-pharmaceuticals (such as disinfectants, deodorizing solutions, etc.) which are designed only for external use is an unfortunate habit encountered in the recent decades in the economically disadvantaged areas of Romania inhabited by poor, uninformed, and sanitary uneducated population. These para-pharmaceutical products are based on different concentrations of ethanol. Occasionally, the manufacturer modifies the product formula, or worse omits on the label that the ethanol was replaced with methanol, resulting in mass poisoning with a large number of casualties. The authors present a case of mass poisoning by methanol that occurred during one month and resulted in 40 cases of methanol intoxication. Only 5 out of the 40 victims survived the intoxication. All the dead victims underwent medico-legal autopsy which revealed only general features, liable to poisoning. The toxicological examination result was positive for methanol in all the cases. All the intoxicated victims were homeless; they were heavy ethanol consumers, especially of the product rubbing alcohol. The male: female ratio was 31:4 and the age range was between 25 and 70 years old, with an average of 50 years. All the victims were hospitalized in deep coma, showing obvious pathological changes specific to chronic ethanol consumption. Conclusions: some alcoholic para-pharmaceutical products manufactured for external use are ingested by chronic ethanol drinkers. When these products contain methanol, they can cause severe intoxication followed by an impressively large number of deaths.
Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease
Authors: Cristache Corina Marilena , Totu Eugenia Eftimie , Tanase Gabriela , Nechifor Aurelia Cristina , Petre Daniel , Burlibasa Mihai
Published: January 2020

A complex formulation for topical treatment, consisting of melatonin, hyaluronic acid, tetracycline, and metronidazole mixture is proposed as periodontal disease adjunctive treatment. In order to follow the structural aspects of the active mixture, spectrophotometric methods: UV-Vis and fluorescence, have been applied. The results obtained complete our previous studies. By adding metronidazole to the mixture composed of: melatonin, hyaluronic acid, and tetracycline, the conjugated effect of the active compounds, combining antimicrobial action with anti-inflammatory and immunomodulatory effect, is expected to significaly improve supportive therapy in moderate forms of periodontitis.
Corrosion Resistance Evaluation of Some Stainless Steels Used in Manufacture of Hydraulic Turbine Runner Blades
Authors: Predescu Cristian , Berbecaru Andrei Constantin , Coman George , Sohaciu Mirela Gabriela , Predescu Andra Mihaela , Matei Ecaterina , Dumitrescu Ruxandra Elena , Ciuca Sorin , Gherghescu Ioana Arina
Published: January 2020

The paper presents corrosion resistance testing results of three stainless steels that may be used in hydropower turbine blades manufacture. Two of these have a chemical composition close to that of some other stainless steels previously employed in producing these parts, being updated steel grades of the former ones. The third one is of a new conception, having a chemical composition close to that of a maraging steel. The three materials were produced in an induction furnace with cold copper crucible under vacuum and argon atmosphere in order to obtain improved mechanical and corrosion resistance characteristics as well as an inclusion � free structure. Quenching and tempering heat treatments were subsequently applied. Tests were carried out at room temperature in normally aerated 1N Na2SO4 and 3% NaCl solutions. Corrosion rates were calculated using the Tafel slope method. All steels have a passivation tendency in a chlorine-free aqueous medium. The newly conceived steel has a more pronounced anodic field as a result of a chromium content below 12%. However, the general corrosion behavior of this material is rebalanced by the content of about 10% Ni which leads to a mainly martensitic structure in quenched state. The corrosion rate values obtained for all samples enframe the three materials in highly and very highly corrosion resistant steels. Nevertheless it must be specified that in chlorine environments the overall corrosion rate is not a sensitive indicator of corrosion resistance performance due to the local depassivation process followed by corrosion pits.
Researches on Blood Biochemical Variations During Pregnancy in Rabbits
Authors: Lazar Roxana , Vintu Catalin Razvan , Boisteanu Paul Corneliu , Simeanu Daniel , Antohe Radu
Published: January 2020

The organism as a biological system, for the normal performance of its functions, needs a wide variety of substances that it needs to obtain from the environment. Their assurance must be rhythmic and balanced in qualitative and quantitative terms. By its chemical composition, the blood plasma transports the energetic and plastic substances from the forming organs to the cells and tissues, but also the products resulting from the cellular and tissue catabolism of the excretory organs. The research was carried out on the Meuse Rabbit by the Belgian Giant, divided into three experimental NP groups (adult, non-pregnant females), P1 (females at 15 days of gestation) and P2 (females at the end of gestation, 30 days). The collection of blood samples was performed with the vacuum system before meals. Subsequently, they were centrifuged at 3000 rpm for 5 minutes to obtain the plasma required for the biochemical examination. Biochemical parameters were determined by spectophotometry using the ACCENT 200. As a result, we observed that gestation is a diabetogenic stress, the fetus uses glucose almost exclusively as an energy source and increases protein needs due to the permanent transfer of amino acids to the fetus. Lipid metabolism is diverted with priority to lipid consumption, about 20% of free circulating fatty acids are transferred to the fetus.
Evaluation of the Effect of Red Onion Extract Consumption in Mice (Mus musculus)
Authors: Spataru Mihaela Claudia , Spataru Constantin , Trofin Alina Elena , Hritcu Luminita Diana , Zamfir Carmen Lacramioara , Enache Georgiana Andreea , Solcan Carmen
Published: January 2020

Red onion (Allium cepa) is commonly used in human diet, representing an important source of flavonoids, with argued therapeutic values in humans. In animals, the tolerance to onion varies according to species and the quantity intake, carnivores being the most sensitive. The experiment aims to identify the negative potential effects in mice after the aqueous red onion extract consumption over 56 days. Similar to some long-term studies performed on other species using aqueous or alcoholic red onion extracts, for the mice of the experimental batch were registered the hepatic and renal disturbances, paraclinically and microscopically registered, which might limit the testing of the effects of the extracts from red onion on mice.
Use of Ethoxylated Surfactants to Improve Digestate Stability
Authors: Oprescu Elena Emilia , Bombos Mihaela , Vasilievici Gabriel , Velea Sanda
Published: January 2020

Thermal or thermocatalytic treatment of sludge resulting from anaerobic digestion in continuous flow installations involves conditioning it in order to homogenise it and stabilize of these suspensions. In this study the digestate resulting in the processing of the algal biomass was conditioned in the presence of potato processing waste. The conditioning was done in several stages. In the first stage, the water content was reduced by controlled evaporation. The partially dried digestate was then ground, and the particle size distribution was determined bydynamic light scattering (DLS) using Nano ZS (Red badge). The digestate suspension was stabilized by adding ethoxylated surfactants and a lipid fraction. The stability of the digestate suspension was determined using a Turbiscan Lab. The stability of the digestate slurry was improved by the addition of lipid fraction and by addition of ethoxylated castor oil.
Multianalytical Study for Establishing the Historical Contexts of the Church of the Holy Archangels from Cicau, Alba County, Romania, for its Promotion as a World Heritage Good I. Assessing the preservation-restoration works from the 18th century
Authors: Sandu Ion , Iurcovschi Cosmin Tudor , Sandu Ioan Gabriel , Vasilache Viorica , Negru Ioan Cristinel , Brebu Mihai , Spiridon Ursu Petronela , Pelin Vasile
Published: January 2020

The present paper is the first instalment of a series focused on establishing some archaeometric characteristics of the modern finishings (mortars, fresco and layers of whitewash) of the Church of the Holy Archangels from Cic�u, Alba County, Romania, in order to assess the shape, with the structural-functional integrity and architectural and artistic aspect of the monument for the last historical context, between 1710 and 1790. This period is the most extensive and less known of the church�s stages of transformation: 11th�12th century (unknown), 15th century (known) and 18th century (partially known), which was very tumultuous from the socio-economic and political point of view. Thus, in the following pages we present the resulting archaeometric characteristics of optical microscopy (OM), scanning electron microscopes in combination with energy-dispersive X-Ray spectrometry (SEM-EDX) and thermal derivatography (TG/DTA/DTG) analyses of two pigments from the exonarthex fresco (made in 1781) and the later eight layers of whitewash applied over it, which allowed assessing the periods with marked changes in the architecture and polychrome finishings.
Two Adhesive Systems-effect on Adhesion to Tooth Structure
Authors: Deac Larisa Simona , Earar Kamel , Colceriu Burtea Adela Loredana , Berghe Alexandra Stefania , Antoniac Aurora , Delean Ada Gabriela , Saceleanu Vicentiu , Raiciu Anca Daniela , Hodisan Ioana Maria
Published: January 2020

This study evaluates and compares by dye penetration method and SEM photomicrographs the sealing obtained using two different classes of adhesive systems (etch-and-rinse and self-etch with selective etching) with SDR (Dentsply) bulk fill composite. 84 class V cavities were prepared on oral and vestibular face of 42 intact, freshly extracted wisdom teeth. The cavities were randomly divided in two groups and restored: Group 1 with prime &bond one select (Dentsply) and SDR (Dentsply) and Group 2 with prime&bond one Etch&Rinse (Dentsply) and SDR (Dentsply). Prime&bond one Select (Dentsply) is a single component adhesive and can be used in self etch mode, in selective enamel etch mode, or in etch-and-rinse mode. We chosen for this study the selective etch of the enamel mode. Prime&bond one Etch Rinse (Dentsply) is a universal etch-and-rinse one-bottle dental adhesive, designed to be used in two steps. The bulk fill composites are commonly used in modern dentistry due to their properties of low polymerization shrinkage and curing in layer of 4 mm depth, offering the practitioner a fast clinical procedure with good results. The results showed a good sealing at enamel and dentin margins with no statistically significant difference between adhesives, even though the mean of enamel infiltration was smaller for Group1. Furthermore the results show that there were differences between the two groups, for the infiltrations at the enamel, the values of microleakage being arithmetically higher for Group 1, but with no statistically difference between the two groups.SEM images showed for both groups a good adhesion surface with the tooth, but the hybrid layer of the total-etch adhesives is different from the hybrid layer formed by self etch adhesives, in terms of thickness, uniformity. In conclusion both adhesive systems have equivalent sealing qualities and can be successfully used with SDR.
Pharmaceutical Applications of Chitosan Extracted from Local Marine Sources
Authors: Apetroaei Manuela R. , Rau Ileana , Paduretu Carla Cezarina , Lilios Gabriela , Schroder Verginica
Published: January 2020

Identification of chitosan from new local marine sources could be a great challenge for research in terms of using this biopolymer in various pharmaceutical, environmental or food applications. In the present study, two chitosan powder samples extracted from processed shrimps waste and Rapana venosa eggs capsules were compared with a food supplement sample based on chitosan, from the point of view of spectral analyses (FTIR spectroscopy), of their solubility in dilute acetic acid solutions (1 %), insoluble substances content, and fats binding capacity. In order to determine the fat binding capacity of the tested chitosan samples, different types of cold pressed vegetables oils (olive oil, sunflower oil, soybean oil, argan oil and coconut oil) and animal fats (butter and pork lard) were used. The present study highlighted that the chitosan samples, chemically extracted with low financial efforts by waste recovery of crustaceans and mollusks from Romanian Black Sea coast, could be an important source with high potential. The obtained results showed a good fat binding capacity, especially for chitosan samples extracted from shrimps waste compared to the chitosan sample chosen as reference. These compounds may be successfully used in pharmaceutical applications, in various formulations as dietary supplement, or as useful therapeutic component in the hypocholesterolemia treatment or in prevention of cardiovascular risk, due to their good solubility in dilute acidic solutions and lower values of insoluble content.