bluuebunny/crossref_metadata_2025 huggingface dataset:
Patients' and Physicians' Perceptions of Audio-Only Gynecology Virtual Clinics: The Experience of a Tertiary Hospital in Jeddah, Saudi Arabia
Authors: Khalil Asma , Alharazi Shahad S. , Bakhamees Farah H.
Published: November 2024

Background/Objectives: Since the outbreak of Coronavirus Disease 2019, virtual clinics served as the cornerstone modality of telehealth in many health institutions. This study aimed to examine patients’ and physicians’ perceptions of audio-only gynecology virtual clinics’ integration. Methods: A cross-sectional study was conducted in a tertiary hospital in Jeddah, Saudi Arabia. A convenient sampling technique was followed for physicians and patients. The questionnaires utilized were validated. Results: During March 2021-March 2022, a total of 220 subjects participated in the study. Physicians accounted for 24.5% (n=54), while patients accounted for 75.5% (n=166). Overall, only 55.5% of the physicians agreed virtual clinics should continue after the pandemic, while 84.6% and 76.0% of the patients reported satisfaction and the wish to use virtual clinics again, respectively. Physicians who seldom found physical examination to be indicated, seldom requested patients to attend physically to the clinic, and who had a positive outlook on virtual clinics were more likely to desire continuing virtual clinics after the pandemic, p<0.001. Patients who had positive outlooks regarding virtual clinics were shown to be more satisfied with virtual clinics, p<0.001. Conclusions: Audio-only gynecology virtual clinics are accepted by both physicians and patients with higher satisfaction among patients. Physicians’ positive outlook yet reluctance to continue virtual clinics suggests the need to modify the conduction of virtual clinics and necessitates larger-scaled prospective studies in this topic.
Time-Course and Fraction Analysis in Western Blot Reveals Improved Approaches for Evaluating Neutrophil Extracellular Trap-Associated Proteins
Authors: Negreros Miguel , Hernández Fernando , Mendoza-Milla Criselda , Cisneros José , Morales-Hurtado Fernando , Flores-Suárez Luis Felipe
Published: November 2024

Neutrophil extracellular traps (NETs) dysregulation is implicated in various diseases, highlighting the need for accurate quantification methods. These methods must account for the unique nature of NETs, where nuclear DNA and intracellular proteins translocate to the extracellular space. This study addresses technical approaches in the Western blot quantification of NETs-associated proteins (NAPs). Neutrophils were isolated from healthy donors, stimulated with phorbol-myristate acetate (PMA), and the expression of cathelicidin antimicrobial protein LL-37 (LL-37/hCAP18), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and β-actin was analyzed over time. LL-37/hCAP18 exhibited temporal and fraction-specific distribution patterns, while the evaluation of GAPDH and β-actin as loading controls emphasized the need for more precise tailoring when studying NETs. This work aims to improve understanding of the techniques used to measure them to make more accurate comparisons in the area of NETs research. Western blot emerges as a robust and accessible tool, shedding light on the dynamics of NAPs.
Liposomal and Nanostructured Lipid Nano Formulations of a Pentacyclic Triterpenoid Birch Bark Extract: Structural Characterization and In Vitro Effects on Melanoma B16F10 and Walker 256 Tumor Cells Apoptosis
Authors: Dumitriţa Rugină , Adrian Socaciu Mihai , Mădălina Nistor , Zoriţa Diaconeasa , Mihai Cenariu , Tăbăran Flaviu , Carmen Socaciu
Published: November 2024

Background/Objectives: Pentacyclic Triterpenoids are increasingly studied as anti-cancer agents with many advantages comparative to synthetic chemotherapeutics. The aim of this study was to prepare liposomal and nanostructured lipid formulations including a standardized extract of silver birch (Betula pendula) outer bark (TTs) and to evaluate their potential as anti-cancer agents in vitro, using Melanoma B16-F10 and Walker carcinoma cells. Methods: Appropriate solvents were selected for an efficient TTs extraction, and original recipes were used to obtain Pegylated liposomes and nanolipid complexes with entrapped TTs, comparative to pure standards (betulinic acid and doxorubicin) in similar conditions. The composition, morphology and sizes of all nanoformulations were checked by High Performance Liquid Chromatography/Mass spectrometry, Transmission Electronic Microscopy and Diffraction Light Scattering. The entrapment efficiency and their impact on cell viability, cell cycle arrest and apoptosis by Flow Cytometry was also measured on both cancer cell lines. Conclusions: The standardized TTs showed good stability, synergistic effects of main components and superior comparative to pure betulinic acid. According to experimental data, TTs showed good entrapment in liposomal and NLC nanoformulations, both delivery systems including natural, biodegradable ingredients and enhanced bioavailability. The apoptosis and necrosis effects were more pronounced for TTs liposomal formulations in both types of cancer cells, with lower cytotoxicity comparative to Doxorubicin, and can be correlated with their increased bioavailability.
Fuzzy Uniform Topology on a PUP-Algebra
Authors: Mechderso Alachew Amaneh , Alaba Berhanu Assaye , Munie Tilahun Mekonnen
Published: November 2024

This paper introduces the concept of extreme fuzzy PUP ideals within the framework of a
PUP algebra. Building on this concept, we investigate a fuzzy uniform structure applicable
to PUP-algebras. We then delve into the idea of a fuzzy uniform topological PUP algebra,
which is a PUP algebra equipped with a distinctive fuzzy topology that ensures the continuity
of both binary operations in a fuzzy topological sense. This approach broadens the scope of
fuzzy uniform topological PUP-algebra, leading to the derivation of numerous properties of
fuzzy topological PUP algebras.
Study of Indian Buddhist Cultural Heritage and Digital Heritage
Authors: Tribhuvan Amrapali
Published: November 2024

Each civilization and each country are influenced by its own culture, traditions, and wisdom. India is world famous for its diverse cultural heritage which is its building blocks. Buddhism emerged in the 6th century BC. This phrase shaped not only India's spiritual history but also its intellectual culture. From India, Buddhism spread throughout Asia. India has many important Buddhist sites. We have selected 15 Buddhist Indian heritage sites for our study. UNESCO defines "digital heritage" as unique resources of human knowledge and expression "created digitally or transformed from existing analogue resources into digital form". With the development of new technologies and the availability of cultural heritage in digital form. In this research work, all selected fifteen Indian Buddhist historical sites nearly two thousand years old. Due to thousands of years of any natural or human-generated disasters, as well as the overloaded tourists’ damages to the heritage sites. The purpose of digital heritage preservation is to ensure that it remain s accessible to the public and to prevent it from disappearing. In this paper we have study digital heritage and this proposed research work present the process for digitally preservation of selected cultural heritage sites.
Effects of Different Intensities Post-Activation Performance Enhancement Protocols on Repeated Sprint Ability in Male Soccer Players: A Randomised Crossover Trial
Authors: Akgül Mustafa Şakir , Tohănean Dragoș Ioan , Akçay Neslihan , Păun Laurian Ioan , Çetin Tuğba , Uysal Hüseyin Şahin , Alexe Cristina Ioana
Published: November 2024

(1) Background: Post-activation performance enhancement (PAPE) protocols using heavy resistance preloading may improve RSA, yet optimal preloading intensity for amateur players is still unknown. This study investigated the effects of two PAPE protocols using different preloading intensities (85% and 90% of 1RM back squat) on RSA. (2) Methods: A double-blind, randomized, two-period crossover design was used, and 18 amateur male players were included in the study. RSA was assessed using a 6 x 35m sprint protocol with 10-second rest intervals (RAST). (3) Results: While the main effect of time significantly (p=0.01, η²=0.71) influenced performance decline across all groups, there was no significant (p=0.65, η²=0.01) interaction between time and condition. Individual responses to PAPE varied, highlighting the importance of individual differences. Interestingly, the BS85% group exhibited a less pronounced decline in performance compared to the control group, while the BS90% group only showed significant differences in three sprint levels. (4) Conclusions: Our findings suggest that a lower preload of 85% of 1RM may be as adequate as a higher preload of 90% of 1RM in enhancing RSA in amateur soccer players. These results may indicate a potential fatigue-delaying effect of PAPE protocols and emphasize the importance of individualized approaches for optimizing PAPE strategies.
Effects and Impact of Selenium on Human Health, A Review
Authors: Bai Song , Zhang Miaohe , Tang Shouying , Li Miao , Wu Rong , Wan Suran , Chen Lijun , Wei Xian , Feng Shuang
Published: November 2024

Selenium (Se) is an essential trace element that is crucial for human health. As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. Currently, over 30 types of selenoproteins have been identified, with more than 20 of them containing selenocysteine residues. Among these, glutathione peroxidases (GPXs), thioredoxin reductases (TrxRs), and iodothyronine deiodinases (DIOs) have been widely studied. Selenium boasts numerous biological functions, including antioxidant properties, immune system enhancement, thyroid function regulation, anti-cancer effects, cardiovascular protection, reproductive capability improvement, and anti-inflammatory activity. Despite its critical importance to human health, the range between selenium's nutritional and toxic doses is very narrow. Insufficient daily selenium intake can lead to selenium deficiency, while excessive intake carries the risk of selenium toxicity. Therefore, selenium intake must be controlled within a relatively precise range. This article reviews the distribution and intake of selenium, as well as its absorption and metabolism mechanisms in the human body. It also explores the multiple biological functions and mechanisms of selenium in maintaining human health. The aim is to provide new insights and evidence for further elucidating the role of selenium and selenoproteins in health maintenance, as well as for future nutritional guidelines and public health policies.
Availability of the Great Saphenous Veins as Conduits for Arterial Bypass Surgery in Patients with Varicose Veins
Authors: Golovina Veronika , Panfilov Vladislav , Seliverstov Evgenii , Erechkanova Darina , Zolotukhin Igor
Published: November 2024

Background
The great saphenous vein (GSV) has long been recognized as a best conduit for vascular bypass procedures. Concomitant varicose veins disease may be a reason for GSV unavailability either due to dilatation and tortuosity of the vein or due to its destruction during invasive venous treatment.
Aim - to assess the rate of varicose vein patients with concomitant lower extremity arterial disease (LEAD) who have previously lost their GSV due to venous ablation.
Material and methods
285 patients (76 F, 209 M) with LEAD were consecutively enrolled. Demographic data and medical history were taken. Physical examination and duplex ultrasound were performed. We registered presence of varicose veins (VVs), type of previous invasive procedure and availability of saphenous veins as possible grafts.
Results
Mean age of screened LEAD patients was 70.5±9.1. 62 (21.75%) patients had varicose veins or were operated on before due to varicose veins. 42 patients with varicose veins had C2 disease, 10 had C3, nine had C4 and one had C6 according to CEAP classification. Duplex ultrasound examination of the veins of the lower extremities was performed on 111 patients (222 lower extremities). The total number of lower extremities without ipsilateral GSV was 76 (34.2%) due to varicosity, small size, previous ablation or postthrombotic intraluminal changes. 53 limbs in 32 patients had VVs. Despite the presence of varicose tributaries, the GSV was suitable for bypass in 9 lower extremities. GSV was not available as a conduit in 34 (20.1%) ipsilateral lower extremities in the LEAD group and in 42 (79.3%) ipsilateral lower extremities in the LEAD with VVs group (p= 0.0001). Varicose vein disease was associated with a higher frequency of the GSV unavailability odds ratio 18.8 (95% confidence interval 8.35 – 42.35). On the 11 ipsilateral limbs (5%) GSV was unavailable due to previous venous interventions.
Conclusions
Almost 20% of patients may have both LEAD and VVs. Among those with VVs, most have the ipsilateral GSV unavailable as a potential conduit. Additionally, one fifth of limbs with VVs had GSVs destroyed previously due to saphenous ablative procedures.
Integral Ecology of Innovation: Bridging Spirituality, Sustainability, and Systems Thinking
Authors: Moleka Pitshou
Published: November 2024

This article forges an unprecedented synthesis between the realms of spirituality, sustainability, and systems thinking, unveiling a transformative framework for an "integral ecology of innovation." By bridging insights from world wisdom traditions, ecological sciences, and complexity theory, the author presents a radically integrative understanding of the interconnected, sacred nature of human and natural systems. Transcending the fragmented, mechanistic worldviews that have long dominated innovation paradigms, this groundbreaking work illuminates innovative design principles, technological solutions, and collaborative processes that embody reverence for the sacredness of life and the regenerative patterns of the biosphere. The visionary ideas explored here represent a watershed moment in redefining the purpose and practice of innovation to align with humanity's highest spiritual and ecological aspirations.
The Impact of Medicaid Expansion on Stage at Diagnosis of Melanoma Patients: A Retrospective Study
Authors: Muddasani Ramya , Wu Helena Tan , Win Shwe , Amini Arya , Modi Badri , Salgia Ravi , Trisal Vijay , Wang Edward Wenge , Villalona-Calero Miguel Angel , Chan Aaron , Xing Yan
Published: November 2024

Purpose: This study evaluates the impact of Medicaid expansion under the Affordable Care Act (ACA) on melanoma staging at diagnosis, treatment utilization, and 3-year mortality outcomes. The objective is to determine whether Medicaid expansion led to earlier melanoma diagnosis and improved survival rates among non-elderly adults (ages 40-64) by analyzing data from the National Cancer Database (NCDB). Methods: A total of 12,667 patients, aged 40-64, diagnosed with melanoma from 2010 to 2020 were identified using the NCDB. Difference-in-difference (DID) analysis was performed to analyze tumor staging at presentation between Medicaid expansion states and non-Medicaid expansion states both prior to the expansion and after the expansion. Results: Of the total patients 2,307 were from the pre-expansion time period residing in Medicaid Expansion states (MES) and 1,804 in non-Medicaid expansion states. In the post-expansion time period there were 5,571 residing in the MES and 2,985 in the non-MES. DID analysis revealed a decrease in stage IV melanoma at diagnosis (DID -0.222, p <0.001) between MES and non-MES before and after Medicaid expansion. After expansion, in stage IV, the occurrence of primary surgery was 0.42 in non-MES and 0.44 (difference 0.02), DID analysis was not statistically significant. The use of immunotherapy in MES was significantly higher than non-MES after expansion (p<0.001), although DID analysis did not reveal a statistically significant difference. DID analysis showed a statistically significant decrease in 3-year mortality (DID -0.05, p=0.001) between MES and non-MES before and after Medicaid expansion. Conclusions: This study revealed the positive impact of the ACA’s Medicaid expansion on melanoma stage at presentation showing improved access to healthcare services can facilitate the diagnosis of early-stage melanoma and decrease mortality rate.
The Influence of the Sowing Rate and Foliar Fertilization on the Yield of Some Tritical Varieties in the Context of Climate Change in Northwest Romania
Authors: Andras Beniamin Emanuel , Fițiu Avram , Acs Balazs Peter , Horga Vasile Adrian , Racz Ionut , Duda Marcel Matei
Published: November 2024

Triticale is recognized worldwide due to its high protein and lysine content, high production capacity and adaptability to biotic and abiotic stress conditions, these qualities being taken over from wheat and rye. Triticale is widely used in various fields such as animal feed in various forms, in medicine, the bakery, beer, alcohol, cellulose, bioethanol industry and many others. Thus, the demand for triticale grains is increasing, and this has led to the research and improvement of culture technology to obtain superior products, both quantitatively and qualitatively. The purpose of this study was to identify the best varieties of triticale cultivated in the north-west of Romania, sown in different plots and fertilized on the ground or additionally, the study being carried out over a period of two years at the Livada Agricultural Research and Development Station, Satu Mare county. The study was located on an acidic soil with a pH between 5.19 and 6.65 and a humus content of 2.82%. The climatic conditions in the reference period were extremely variable, in the first year a deficit of more than 90 mm/m2 of precipitation was registered, and in the second year of the study, an increase of more than 34 mm/m2. The effects of additional fertilization were influenced by the level of precipitation, so in the experimental variants additionally fertilized, lower productions were obtained compared to the variants fertilized only on the soil. Compared to the Negoiu control, the Utrifun variety proved to be the most productive, but this will be proven in the following years of study, under different climatic conditions.
Mechanistic Relevance of Ventricular Arrhythmias in Heart Failure with Preserved Ejection Fraction
Authors: Pegah Bahrami Pegah , Aromolaran Kelly , Aromolaran Ademuyiwa
Published: November 2024

Heart failure with preserved ejection fraction (HFpEF) is increasing at an alarming rate worldwide, with limited effective therapeutic interventions in patients. Sudden cardiac death (SCD) and ventricular arrhythmias present substantial risks for the prognosis of these patients. Obesity is a risk factor for HFpEF and life-threatening arrhythmias. Obesity and its associated metabolic dysregulation, leading to metabolic syndrome, are an epidemic that poses a significant public health problem. More than one-third of the world population is overweight or obese, leading to an enhanced risk of incidence and mortality due to cardiovascular disease (CVD). Obesity predisposes patients to atrial fibrillation and ventricular and supraventricular arrhythmias—conditions that are caused by dysfunction in the electrical activity of the heart. To date, current therapeutic options for cardiomyopathy of obesity are limited, suggesting that there is considerable room for the development of therapeutic interventions with novel mechanisms of action that will help normalize sinus rhythms in obese patients. Emerging candidates for modulation by obesity are cardiac ion channels and Ca-handling proteins. However, the underlying molecular mechanisms of the impact of obesity on these channels/Ca-handling proteins remain incompletely understood. Obesity is marked by the accumulation of adipose tissue, which is associated with a variety of adverse adaptations, including dyslipidemia (or abnormal systemic levels of free fatty acids), increased secretion of pro-inflammatory cytokines, fibrosis, hyperglycemia, and insulin resistance, which cause electrical remodeling and, thus, predispose patients to arrhythmias. Furthermore, adipose tissue is also associated with the accumulation of subcutaneous and visceral fat, which is marked by distinct signaling mechanisms. Thus, there may also be functional differences in the outcome of regional distribution of fat deposits on ion channel/Ca-handling protein expression. Evaluating alterations in their functional expression in obesity will lead to progress in the knowledge about the mechanisms responsible for obesity-related arrhythmias. These advances are likely to reveal new targets for pharmacological modulation. The objective of this study is to review cardiac ion channel/Ca-handling protein remodeling in the predisposition to metabolic HFpEF and arrhythmias. Understanding how obesity and related mechanisms lead to cardiac electrical remodeling is likely to have a significant medical and economic impact.
Opinions of Gynaecologists about Indication and Technique of Perineoplasty
Authors: Swieten Esther CAM van , Stralen Karlijn J van , Vollebregt Astrid , Roovers Jan-Paul WR
Published: November 2024

Conclusions. Perineoplasty is a frequently performed procedure. There is a wide variation on indications for- and surgical technique of- perineoplasty. Therefore research is needed to identify which patients will benefit of perineoplasty and how to optimally perform this surgery.
Ultraviolet and Microwave Irradiation Could Easily Serve a Double Purpose for the Raw Food Nutrition
Authors: Nakashima Moeka , Fukumoto Akari , Matsuda Satoru
Published: November 2024

Agricultural food supplies, in particular raw vegetables for example with a preference of raw foods, are susceptible to contamination by several microorganisms, which may threaten human health. The regulation of the pathogenic load on foodstuffs has been a key element in food safety. Equipment such as ultraviolet radiation or microwave irradiation could effectively, easily, but partially resolve the problem of these contamination that cannot be achieved by traditional methods such as water washing at the consumer level. Ensuring the safety and quality of food through preservation is of extreme importance. However, the incomplete pasteurization might nonetheless contribute to the development of human health with a concept of hermetic effects. Here, an innovative and alternative approach for food sanitation would theoretically be introduced for the original evaluation of risks/benefits of microbiological cause related with food consumption.
Machine Learning in Occupational Health and Safety: A Review of Knowledge Gaps
Authors: Nadler David
Published: November 2024

Machine learning is revolutionizing the way we work and the field of occupational health and safety (OHS) has significant knowledge gaps for its implementation. This review synthesizes current applications across hazard identification, risk assessment, ergonomics, PPE compliance monitoring, and environmental surveillance, while identifying critical areas for future research. Even with promising advances, challenges persist in developing machine learning models that work effectively across industries, integrate multi-modal data streams, and adapt to dynamic work environments. Key limitations include the need for more robust assessment tools, personalization capabilities, and solutions to data quality and privacy concerns. The field particularly lacks standardized frameworks for data collection and sharing, as well as clear ethical guidelines for implementing machine learning in workplace safety contexts. This analysis reveals promising research directions, including the development of explainable AI systems to support OHS decision-making, learning applications to address data scarcity, and privacy-preserving learning approaches. The integration of machine learning with internet-of-things (IoT) and extended reality technologies offers additional avenues for innovation. Advancing these opportunities requires interdisciplinary collaboration between OHS professionals, computer scientists, lawyers, and subject matter experts. This review concludes that realizing the full potential of machine learning in OHS depends on addressing both technical and organizational challenges. A focus on these identified research priorities in this field can make significant advances toward creating more effective, data-driven tactics to workplace safety and health management.
Dikiş Diken Kadınlarda Boyun Ağrısının ve Postüral Özelliklerin İncelenmesi
Authors: Derdiyok Fatma Betül , Atalay Emre Serdar
Published: November 2024

Amaç: Araştırmanın amacı, dikiş dikme aktivitesinin 20-60 yaş aralığındaki kadınların postürü ve servikal bölge ağrısı üzerine etkisini incelemektir. Gereç ve Yöntem: Araştırma 20- 60 yaş aralığında son 6 aydır haftada en az 3 saat dikiş diken toplam 62 kadın ile yapılmıştır. Kadınların meslekleri, Boyun Özür İndeksi (BÖİ) ve Fiziksel aktivite [FIT skoru (Frequency- Intense- Time)] İndeksi verileri online anketler ile alınmıştır. Kadınların anterior ve lateral postürü online görüntülü ve yüz yüze yapılan görüşmelerde değerlendirilmiş ve New York Postür Değerlendirme Yöntemi (NYPDY) üzerinde puanlandırılmıştır. Bulgular: Değerlendirmeye alınan kadınların yaş ortalaması 43,08 ± 10,18 yıldı. Çalışmaya 26 haftanın en az 5 günü mesleki amaçlı, 36 haftanın en az 1 günü hobi amaçlı dikim yapan kadın katıldı. Katılımcıların Boyun Özürlülük Sorgulama İndeksi skor ortalaması 9,90 ± 6,52, FIT skor ortalaması 17,56 ± 17,94 ve New York Postür Değerlendirme Testi skor ortalaması 54,04 ± 6,26 bulundu. Ayrıca postür değerlendirme sonuçlarına göre %58,1 oranına omuzlarda eşitsizlik ve %62,9 oranda hafif omuz protraksiyonu; boyun postürlerinde %80,6 oranında baş anterior tilti olduğu görülmüştür. Kadınların postürleri ve boyun özürlülük derecesi arasında 0,385 (p=0,01) değerinde negatif korelasyon olduğu görülmüştür.Sonuç: Katılımcıların boyun özürlülük derecesi “hafif özürlülük”, fiziksel aktivite düzeyleri “sedanter”, postürleri “çok iyi” olarak bulunmuştur. Katılımcıların postürü ile boyun özürlülük derecesi arasında negatif bir ilişki olduğu görülmüştür. Katılımcıların çoğunda omuz ve servikal bölge postürlerinde olumsuz etkilenim olduğu saptanmıştır. Bu nedenle dikiş diken kadınlarda boyun ve omuz postürlerini düzeltici yaklaşımlar üzerinde yoğunlaşılabileceğini düşünmekteyiz. Dikiş diken kadınların postürleri ve boyun ağrılarını inceleyen ve daha fazla katılımcı dahil edilerek yapılacak çalışmalara ihtiyaç vardır.
Sağlık Personeli- Hasta- İlişki Anketi (Shia)’nin Türkçe Formunun Geçerlik Güvenirlik Çalışması
Authors: Kovancı Mustafa Sabri , Atlı Özbaş Azize , Kalkan Eren Can
Published: November 2024

Amaç: Bu çalışmada, Sağlık Personeli- Hasta- İlişki Anketi’nin Türk kültürü uyarlanması, geçerlik ve güvenirliğinin test edilmesi amaçlanmıştır. Gereç ve Yöntem: Metodolojik tipte tasarlanan çalışma, 01.09.2020-01.03.2021 tarihleri arasında, 320 hemşire ile online formatta gerçekleştirilmiştir. Verilerin toplanmasında “Sosyodemografik Bilgi Formu” ve “Sağlık Personeli- Hasta- İlişki Anketi” Türkçe formu kullanılmıştır. Dil ve kapsam geçerliği yapılan ölçeğin yapı geçerliği, doğrulayıcı faktör analizi ve açıklayıcı faktör analizi ile belirlenmiştir. Ölçeğin güvenirliği ise tüm madde ve alt boyutlar için Cronbach’s Alpha kat sayısı, eş değer yarılar (split halt) yöntemi ve madde bütün korelesyonu kullanılarak değerlendirilmiştir. Bulgular: Ölçeğin, kapsam geçerlik indeks değeri 0,92 olarak bulunmuştur. Yapılan doğrulayıcı faktör analizi sonucunda değerlerin kabul edilebilir sınırların altında olduğunu tespit edilmiş ve açıklayıcı faktör analizi yapılmıştır. Analiz sonucunda, Türk dili ve kültüründe tek faktörlü yapının geçerli olduğu bulunmuştur. Ölçeğin Cronbach Alfa katsayısı toplam ölçek için 0.92’dir.Sonuç: Sağlık Personeli- Hasta- İlişki Anketi’nin, 16 madde ve tek alt boyutlu yapısının Türk dili ve kültüründe sağlık çalışanlarının iletişim becerilerini öz değerlendirilmesinde kullanılabilecek geçerli ve güvenilir bir ölçüm aracı olduğu belirlenmiştir.
Kırsal Kesimde Yaşayan Kadınların Beslenme Okuryazarlığının Değerlendirilmesi
Authors: Topçu Sevcan , Torpil Hilal
Published: November 2024

Amaç: Bu çalışmanın amacı kırsal bölgede yaşayan kadınların beslenme okuryazarlığının ve etkileyen faktörlerin belirlenmesidir. Gereç ve Yöntem: Bu tanımlayıcı çalışmanın örneklemini kırsal kesimde yaşayan 327 kadın oluşturmuştur. Veriler Tanıtıcı Bilgi Formu ve Yetişkinlerde Beslenme Okuryazarlığı Değerlendirme Aracı ile toplanmıştır. Verilerin analizinde tanımlayıcı istatistikler ve regresyon analizi kullanılmıştır. Bulgular: Araştırmada yer alan kadınların yaş ortalaması 36,97±11,25’dir. Kadınların %70’i evli, %68,8’i çocuk sahibi ve %40,1’i ortaokul mezunudur. Kadınların Yetişkinlerde Beslenme Okuryazarlığı Değerlendirme Aracı puan ortalaması 23,66±4,54’dür. Regresyon analizi sonucunda medeni durum (p<0,05), eğitim durumu (p<0,05) ve tanı konulmuş hastalık sahibi olma (p<0,05) değişkenlerinin pozitif yönde, yaş (p<0,05) ve sigara kullanma durumunun (p<0,05) ise negatif yönde kadınların beslenme okuryazarlığını istatistiksel olarak anlamlı düzeyde etkilediği bulunmuştur. Sonuç: Kırsal kesimde yaşayan kadınların beslenme okuryazarlığı, genel beslenme bilgisi, okuduğunu anlama ve yorumlama, besin grupları bölümlerinde sınırda, porsiyon miktarları, gıda etiketi ve sayısal okuryazarlık bölümlerinde yetersiz düzeyde beslenme okuryazarlığı bilgisine sahip oldukları bulunmuştur.
Yüksek veya Önerilen Miktarda Proteinli Diyet ile Birlikte Yapılan Kuvvet Egzersizlerinin Vücut Bileşimi ve Performansa Etkisi
Authors: Karatoprak Abdulhakim , Ersoy Nesli , Ersoy Gülgün
Published: November 2024

Amaç: Bu çalışmada, vücut geliştirme amacıyla kuvvet egzersizi yapan genç erkek bireylere verilen yüksek ve önerilen miktarda proteinli diyetin, vücut bileşimi ve performans üzerindeki etkisini değerlendirmek amaçlanmıştır. Gereç ve Yöntem: Sekiz hafta boyunca kuvvet egzersizleri yapan, 18-35 yaş arası, Beden Kütle İndeksi (BKİ) 30 kg/m²’den az olan, 26 gönüllü erkek birey çalışmaya alınmış ve katılımcıların 11’i önerilen miktarda proteinli diyet, 15’i yüksek proteinli diyet tüketmiştir.Bulgular: Önerilen miktarda protein içeren diyet grubu 1. hafta 1,97 g/kg/gün, 8. hafta 1,98 g/kg/gün, yüksek proteinli diyet grubu ise 1. hafta 2,63 g/kg/gün, 8. hafta 2,58 g/kg/gün protein tüketmiştir. Çalışmada katılımcılardan performanslarının değerlendirilmesi için; 900 Çömelme, mekik (sit-ups), şınav (push-ups), barfiks (pull-ups) ve bench press testini (1-RM) çalışmanın başında ve sonunda tekrarlaması istenmiştir. Bireylerin protein alımlarına bağlı olarak kas kütlelerindeki, çalışma başlangıç ve sonundaki farklar önerilen miktarda proteinli diyet ve yüksek proteinli diyet grubunda sırayla; 1,08±0,71 kg ve 1,35±0,60 kg, yağ kütlelerindeki farklar; -1,26±1,92 kg ve -2,66±1,75 kg, vücut yağ yüzdelerindeki farklar -1,07±1,78 ve -3,01±1,90’dir. Yüksek proteinli diyet grubunda vücut yağ yüzdesi düşüşü istatistiksel olarak önemli (p=0,006; p<0,05), kas kütlesinde artış olmasına karşın bu artış istatistiksel olarak önemsiz, 900 çömelme testi (p=0,032; p<0,05) ile şınav (push up) (p=0,024; p<0,05) testlerinde görülen fark ise istatistiksel olarak önemli bulunmuştur. Sonuç: Kuvvet egzersizi ile birlikte diyete kaliteli protein kaynaklarının eklenmesi ile vücut kas kütlesinin korunduğu ve yağ kütlesinin azalmasına yardımcı olduğu belirlenmiştir.
Fizyoterapi ve Rehabilitasyon Bölümü Öğrencilerinin Öğrenme Stilleri, Yaşam Boyu Öğrenme Yeterlikleri ve Harmanlanmış Öğrenmeye Yönelik Tutumlarının İncelenmesi: Hacettepe Üniversitesi Örneği
Authors: Doğan Mert , Kılınç Muhammed , Aksu Yıldırım Sibel
Published: November 2024

Amaç: Gelişen teknoloji ve toplumsal gelişmeler üniversitelerde öğretim modelleri ve öğrenci-öğretici etkileşiminde birtakım yeniliklere olan ihtiyacı göz önüne sermektedir. Bu doğrultuda araştırmanın amacı Hacettepe Üniversitesi fizyoterapi ve rehabilitasyon (FTR) bölümü öğrencilerinin; öğrenim stillerini, yaşam boyu öğrenme yeterliklerini ve harmanlanmış öğrenmeye yönelik tutumlarını tanımlamak ve aralarındaki ilişkiyi 31 Aralık, 2022incelemektir.Gereç ve Yöntem: Araştırmaya katılmayı gönüllü olarak kabul eden öğrencilerin demografik bilgileri, sınıfları, genel not ortalamaları “genel değerlendirme formu” ile, öğrenme stilleri “Kolb Öğrenme Stilleri Envanteri (KÖSE-III)” ile, yaşam boyu öğrenme becerilerine özgü yeterlikleri “Yaşam Boyu Öğrenme Yeterlikler Ölçeği (YBÖYÖ)” ve çevrimiçi, yüz yüze ve harmanlanmış eğitime yönelik tutumları ise “Harmanlanmış Öğrenme Ortamlarının Etkililiği Ölçeği (HÖOEÖ)” ile “Google Forms” üzerinden kaydedildi. Bulgular: Araştırma, 229 öğrencinin katılımı ile tamamlandı. Öğrencilerin %79,4’si kadın ve %20,6’i erkekti. Öğrencilerin öğrenme stilleri; %58,1 değiştiren, %14,4 özümseyen, %7,9 ayrıştıran ve %19,7 yerleştiren tip olarak saptandı. Öğrenme stillerinin, YBÖYÖ ve HÖOEO puanları ile bir ilişkisi saptanamadı (p<0,05). Öğrenirken soyut kavramayı kullanan öğrencilerin, akademik olarak daha az başarılı olduğu gözlendi. Öğrencilerin YBÖY düzeyleri ve HÖOEO tutumları arasında istatistiksel olarak anlamlı ve orta düzeyde kuvvete sahip bir ilişki bulundu (p<0,05).Sonuç: Yaşam boyu öğrenme becerileri bakımından öğrencilerin, orta-yüksek düzeyde yeterliğe sahip olduğu görüldü. Ayrıca, öğrencilerin yüz yüze, çevrimiçi ve harmanlanmış öğrenme ortamlarına yönelik olumlu tutumlarının olduğu tespit edildi. Araştırmamızdan elde edilen veriler, FTR öğrencilerinin; öğrenme ortamı fark etmeksizin problem çözme yaklaşımı, vaka senaryoları ve/veya simülasyonlarını barındıran ders içerikleriyle daha kolay, etkili ve verimli bir şekilde öğrenebileceğini dolaylı yoldan göstermektedir.
Keyfi Adında Olan İçecek: Kefirin Diş Hekimliğindeki Yeri ve Periodontolojideki Geleceği
Authors: Şahin Tuğba , Özmeriç Nurdan
Published: November 2024

İnsanda ağız içerisinde yaklaşık 700 çeşit mikroorganizma bulunmaktadır ve bu mikroorganizmalar insan ağız mikrobiyotasını oluşturur. Ağız mikrobiyotası, insan vücudundaki en karmaşık mikrobiyal topluluklardan biridir. Ağız mikrobiyatasının bir çok sistemik hastalıkla ilişkisi olduğu tespit edilmiştir. Ayrıca ağız mikrobiyatasındaki patojen mikroorganizmalar oral hastalıklar olan çürük, periodontal hastalık ve oral kansere yol açmaktadır. Periodontal hastalıklar ve diş çürüğü mikrobiyal dental plak içerisindeki spesifik bakterilerin neden olduğu hastalıklardır. Ağız içerisinde hastalığa sebep olan mikroorganizmaların sayısının azaltılması, patojenitelerinin inhibe edilmesi ya da patojen olmayan bakterilerle ağız ortamının regüle edilmesi bu hastalıkların oluşmasını engellemektedir. Günümüzde içeriğinden dolayı bu regülasyon için kullanılan süt ürünleri ve probiyotikler mevcuttur. Kefir; laktik asit bakterileri, asetik asit bakteri ve torula mayalarını içeren kefir danelerinin sütü fermente etmesi ile elde edilen içilebilir kıvamdaki süt ürünüdür. Antibakteriyel, hipokolesterolemik, antihipertansif, antienflamatuar, antioksidan, antikarsinojenik, antialerjenik aktivite, plazma glikoz kontrolü ve yara iyileştirici etkilere sahiptir. Bu etkilerden özellikle kefirin, organik asitlerin (hidrojen peroksit, asetaldehit, karbondioksit) ve bakteriyosinlerin oluşumu nedeniyle birçok patojenik organizmaya karşı antibakteriyel etkisi dikkat çekmektedir. Bunların yanında gastrointestinal rahatsızlıkların tedavilerinde kullanılmaktadır. Kefirin çürük etkeni olan bakterilerin azaltılmasında etkili olduğu ve probiyotik bakteri içeriği de göz önünde bulundurulduğunda periodontal bakterilerin azaltılmasında etkili olabileceği düşünülmektedir. Bu bilgiler ışığında, periodontal hastalık önlemedeki etkisinin daha iyi anlaşılabilmesi için daha fazla sayıda uzun dönem randomize kontrollü klinik çalışma yapılması gerektiği düşünülmektedir.
Enfermedad renal en pacientes mexicanos con diabetes mellitus tipo 2 y sus características sociodemográficas
Authors: Gutiérrez-Alba Gaudencio , Montero-Mora Judith Guadalupe , Gutiérrez-Polo Romana , Ramírez-Cabrera José Bernabé , Castro-Miranda Benjamín
Published: November 2024

Objetivo. Determinar en pacientes sin seguridad social con diabetes mellitus tipo 2, la prevalencia de enfermedad renal (ER), sus características clínicas y sociodemográficas. Material y métodos. Estudio transversal y analítico, participaron 980 pacientes sin diagnóstico de ER de 86 centros de salud. Para la asociación de ER con otras variables se utilizó el test de Fisher y la prueba χ2 de Pearson; también, se ajustó un modelo de regresión logística ordinal múltiple. Resultados. La prevalencia de ER fue de 53%, el estadio 2 con 33.98% y 2.76% para los estadios 4-5. Además, 75% de los pacientes con hemoglobina glucosilada ≥6.5 y múltiples comorbilidades. Los factores asociados con ER fueron la edad, proteinuria y consumo de antinflamatorios no esteroideos. Conclusiones. El reto del sistema de salud es mejorar las competencias del personal de salud para controlar las enfermedades no transmisibles, realizar diagnóstico precoz y brindar atención por estadio de ER.
65 años de Salud Pública de México: identidad, compromiso, pasión y movilización de ideas sobre su propia experiencia
Authors: Lazcano-Ponce Eduardo
Published: November 2024

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Linear Regression with Fibonacci-Derived Polynomials for Temperature Prediction Model
Authors: Ameen Ahmed O. , Fashanu Johnson O.
Published: November 2024

This research work explores the integration of Fibonacci-derived polynomial and linear equations from Fibonacci numbers into a machine learning framework for predictive modeling of environmental datasets, such as wind speed, temperature, and humidity. The research aims to evaluate the effectiveness of combining deterministic mathematical equations with traditional machine learning techniques to improve prediction accuracy and uncover hidden patterns in natural datasets. This novel approach was implemented on a number of models which showed a good result for further research. The linear and Fibonacci-derived polynomial equations showed features of machine learning and since the Fibonacci pattern have been adopted in natural science, this technique of using the deterministic mathematical equation for feature engineering became fitting for natural dataset, the option of working with time series and environmental dataset have shown encouraging result and an above average accuracy.
Socioeconomic Inequalities in Ideal Cardiovascular Health in Kenya: A Decomposition Analysis
Authors: Oguta James , Breeze Penny , Akoth Catherine , Wambiya Elvis , Mbuthia Grace , Otieno Peter , Gathecha Gladwell , Onyango Elizabeth , Kisaka Yvette , Dodd Pete
Published: November 2024

Understanding the magnitude and determinants of socioeconomic inequalities in ideal cardiovascular health (iCVH) is critical for informing targeted cardiovascular disease (CVD) prevention interventions in Kenya. This study assessed the socioeconomic inequality in iCVH, as defined by the American Heart Association 2010 guideline, in Kenya using data from the 2015 World Health Organization (WHO) STEPwise survey on non-communicable disease (NCD) risk factors. The concentration index (C) and curves were used to assess the magnitude of the inequalities and Wagstaff-type decomposition analysis performed to examine the drivers. Pro-rich inequalities were observed in iCVH (C = 0.08; p = 0.006) and were more pronounced in females than males. Wealth (30.7%), urban residence (31.4%), region (16.5%), and education (8.5%) were the highest contributors to the observed pro-rich inequality in iCVH. This study highlights the need for the design and scale up of equity and gender-focused interventions targeting the poorer and less-educated individuals especially in urban areas.
Regional differences are at the heart of a global protein transition
Authors: Simon Wolfram , Gerwien Laura , Hijbeek Renske , Zanten Hannah Van
Published: November 2024

Redesigning a food system based on the protein transition is seen as a key strategy to enhance sustainability. Our results showed that the protein transition indeed largely reduces land use by up to 91% or greenhouse gas emissions by up to 92% while producing healthy diets around the world. This environmental improvement was achieved by reallocating resources within the food system and dietary changes. On a global average, the consumption of protein, especially proteins from animals, was reduced. However, certain regions like Sub-Saharan Africa showed an increase in proteins from animals. Overall, not only protein but also energy, total fat, vitamin B12, and calcium are the limiting nutrients in diets. Our findings highlight that average protein metrics on a global scale will not give direction to the regional production and consumption changes needed. A region- and context-specific approach is required to account for the complexity of the protein transition.
Amplified Fluorescence detection of SARS-CoV-2 Nucleocapsid Protein based on Enzyme-Powered Gold Nanoparticle Sensor
Authors: Ma Lisa , Hu Min , Lin Yingzi , Nie Zhun , Li Yanna , Dong Lijian , Chen Shouang , Wang Yongxia , Xia Qianfeng
Published: November 2024

The spread of COVID-19 has affected countless numbers of people across the globe since the outbreak of the pandemic in 2019. Rapid and accurate diagnosis plays a crucial role in the epidemic disease prevention and control. Nucleocapsid protein (N protein) is the most abundant and high conserved protein in SARS-CoV-2, making it an ideal marker for the early diagnosis of SARS-CoV-2 infection. However, detection of clinical specimens for N protein remains a challenge due to false-positive results because of antibody cross-reaction with antigen in host antibody-based testing. In this work, we fabricated an enzyme-powered gold nanoparticle based fluorescent signal amplification platform for sensitive detection of N protein with the help of DNA aptamer. Briefly, three DNA strands, designated as S1, S2, and S3, were pre-hybridized to create a DNA triplex and the report probe F/S4 strand was preassembled onto AuNPs. In this platform, aptamer was left to keep their original structure until meet target, thus making them easier to recognize the protein. According to our design, in absence of target, aptamer could bind to S2 strand, resulting in the release of the S2 from the S1/S2/S3 triplex. The remaining partial S1/S3 DNA duplex resisted the lysis of Exo III to S1 strand, due to the absence of a blunt or concave end at 3′ terminus in S1, and the S3 based fluorescent signal amplification process could not trigger. No fluorescence signal was observed due to the quenching effect between AuNP and FAM. However, in the presence of target, the enzymatic cycling signal amplification process could be triggered by the S1/S2/S3 triplex to pursue highly sensitive detection for N protein. A linear range of 0.1 ng/mL -1µg/mL is achieved with a detection limit of 0.08ng/mL for N protein.
Amorphous-like TiN films as barrier layers for copper
Authors: Han Shicheng , Yang Shicheng , Zeng Xiaohong , Liu Tong , Wang Hu , Wu Ying , Ding Sunan
Published: November 2024

The titanium nitride (TiN) columnar structure results in a rapid diffusion of copper atoms into the substrate along a vertical path. In this paper the TiN columnar growth process was modified, which resulted in the deposition of amorphous-like films. The amorphous-like TiN layer demonstrated a low resistivity of 75.3 \(\:\mu\:\varOmega\:\cdot\:cm\). For the test structure of Cu/TiN/SiO2, the Cu diffusion depth in the 3nm TiN middle layer was only approximately 1 nm after annealing at 750°C for 30 min. Excellent copper diffusion barrier due to high density and complex diffusion pathways. The results of this study suggest that conventional barrier materials can still be used in ultra-narrow copper interconnects.
Hybrid model development emulating linear polarization resistance method towards optimizing dosages of corrosion inhibitors
Authors: Jayaweera Chamanthi Denisha , Hitsov Ivaylo , Pozo David Fernandes , Ketelaere Elias , Depover Tom , Müller Sarah Isabell , Diekow Thomas , Verliefde Arne , Nopens Ingmar
Published: November 2024

Models that have been developed for optimizing dosages of a corrosion inhibitor are based on corrosion inhibition efficiencies quantified using costly and time-consuming measurements. The current study proposes a methodology for using corrosion data regularly generated from cooling water circuits of large-scale chemical plants to analyse corrosion mechanisms, predict the corrosion rate, and to potentially optimise dosages of multiple corrosion inhibitors. The hybrid model was developed based on an adaptation of the Butler-Volmer equation. Butler-Volmer parameters such as the anodic charge transfer coefficient were modeled as nonlinear functions of a single component of partial least squares (PLS), containing inhibitor concentrations. A suitable indicator of corrosion inhibition efficiency was identified from the model. Adequately capturing the relationship between inhibitors and the corrosion rate facilitates optimizing dosages of corrosion inhibitors using daily recorded data, without heavily relying on case-specific models and experiments.
Long enough but not too long: a posteriori determination of the dwell time margins from high-resolution passenger flow data.
Authors: Baali Mehdi , Kuipers Ruben , Coulaud Rémi , Buisson Christine , Palmqvist Carl-William
Published: November 2024

Dwell time is crucial for railway operations corresponding to 20 % of the total travel time in a mass transit context. With this, it is also a source of delays due to its stochastic nature. One way to ensure the robustness of a timetable is to add margins and much work has been done on run time margins. On the other hand, dwell time margins received little attention, except for a few heuristics. This paper aims to provide a novel method to define dwell time margins. To do so, we introduce the notion of tight dwell time (dwell without margins) in this work and compute it from high-resolution passenger flow data. Then, we propose two novel methods (the cluster method and the quantile method) to estimate it. Given the access to this data, the method enables the estimation of the tight dwell time for all the stops while existing heuristics are limited to late trains and/or few passengers. Our developed method highlights the propensity of existing heuristics to overestimate what they measure. The estimation, a posteriori, of dwell time margins thanks to the computed tight dwell time would help design future timetables.