bluuebunny/crossref_metadata_2025 huggingface dataset:
GBA ADVERTISMENT : PENDEKATAN BERBASIS GENRE DALAM PEMBUATAN IKLAN PARIWISATA MAHASISWA VOKASI
Authors: Listriyawati Nyoman Ardiana
Published: October 2021

This study tried to applied the Application of Genre Based Approach to students to write advertisements in English class at Universitas Airlangga. This research was classified as qualitative by trying to find information related to lecturers who applied the Genre Based Approach for third-semester students, modifications made by lecturers in the application of the Genre Based Approach, and the results of student work in responding to the implementation of the Genre Based Approach. This research included describe, recorded, and categorized with observation and interview techniques, where the description of data analysis is presented textually. The results showed that the lecturers have implemented all stages in the Genre-Based Approach with some modifications that are tailored to the needs of students, then all student works have fulfilled the purpose of an advertisement, namely to promote tourist attractions and attract readers to come and visit these places.
Barreiras enfrentadas por mulheres vivendo com o HIV no relacionamento afetivo-sexual: revisão integrativa
Authors: Barros Alice Nunes de , Barros Júlia Rodrigues Guimarães , Alves Regina de Souza , Santos Priscilla Souza dos , Lima Flávia dos Santos , Calixto Débora Mical de Almeida , Melo Beatriz Raquel Fonseca dos Santos , Reis Renata Karina
Published: October 2021

O presente trabalho tem como objetivo buscar evidências na literatura sobre as barreiras enfrentadas por mulheres vivendo com o HIV no relacionamento afetivo-sexual. Trata-se de uma revisão integrativa de literatura, feita por levantamento bibliográfico nas bases de dados Scientific Eletronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Banco de Dados em Enfermagem (BDENF) e US National Library of Medicine National Institutes of health (PubMed) durante o mês de setembro de 2020. Os critérios de inclusão foram estudos publicados na íntegra no período de 2015 a 2020, no idioma português e inglês que estivessem disponíveis gratuitamente online. Foram descartados os artigos duplicados, monografia, dissertação, tese, revisões e os que não corresponderam ao objetivo da pesquisa. Foram identificados 2.090 artigos, mas somente 7 artigos atenderam aos critérios de inclusão e exclusão. Sendo quatro (57,2%) encontrados na SciELO, dois (28,6%) na BDENF e um (14,2%) no LILACS.  O presente estudo permitiu perceber que os principais obstáculos enfrentados por mulheres vivendo com o HIV no aspecto afetivo-sexual são de cunho emocional, psicológico e social, tornando-se notáveis os diversos impactos que o diagnóstico do HIV causa na vida das mulheres.
LANDMARK-BASED VISUAL PLACE RECOGNITION
Authors: Gavali Swapnali , Momin Dr. Bashirahamad
Published: October 2021

— Landmark recognition is one type of problem of
object recognition that has not been well solved. The
classical techniques used for object recognition can not be
applied directly due to a large number of landmarks and a
highly imbalanced dataset. This paper presents the
application of a triplet network for large scale landmarkbased visual place recognition. By fine-tuning pre-trained
convolutional neural network (CNN) and minimizing
triplet loss, the triplet network can learn appropriate
metrics so that most similar images can be retrieved
through algorithms for the k-nearest neighbor (KNN). The
performance of the proposed method is evaluated on a
data set for the recognition of real-world landmarks.
IMPLEMENTATION OF IOT ON VEHICLE PAYLOAD MONITORING
Authors: C Jeeva , K S Ganesh , A Gowtham , D Barathwaaj
Published: October 2021

The continuous development and evolution of
electric vehicle causes the electric car manufacturers to face
new challenges. Now, the lithium-ion batteries are widely
used in electric vehicles which has high current discharge
rate. During overloading, electric motor draws large
amount of current which leads to degradation in battery life
and overheating. Most of the time, the user is unaware of
vehicle loading. This paper discusses the method to
overcome this issue by estimating vehicle load on real time
and alerting the use of vehicle. Using load cell to measure
the data and send the data to the cloud by means of Amazon
Web Services (AWS). When the vehicle is overloaded, a
notification sent to the user. Realtime loading data is shown
on dashboard. Using evolving Technologies like IoT makes
easy to storing the data on cloud. This enables service
engineers to evaluate and improve vehicle, based on
working conditions for future needs. This can also be used
for future needs like reliable range prediction of electric
vehicle and autonomous vehicle driving system.
DESIGN AND FABRICATION OF BLACKBOARD CLEANER
Authors: A Vimal , N Abinesh , J Abiram , C Abishack , Kumar V Akash
Published: October 2021

One of the traditional ways of teaching
learning process is carried out by using blackboards in
classrooms. Blackboards and chalk are inseperable from
classrooms. Thus the dusts from chalk can cause some
health hazards when the human inhaled it over a long
period of time. Hence an attempt has been made by
introducing black board cleaner which is operated by six
bar mechanism. Its working is similar to the wipers in
automobiles. It reduces the potential work of the person
who erase the board and reduces the time consumption in
cleaning the blackboard. It also prevent the exposure of
chalk dust to atmospheric air and helps to create a dust
free classrooms.
A COMPREHENSIVE SURVEY OF VARIOUS CLUSTERING PARADIGMS
Authors: Kangane Pranav , Joshi Vivek , Kacker Astha , Jain Manan
Published: October 2021

Clustering is one of the most significant tasks in
data mining. It is highly significant in the entire procedure
of knowledge discovery. Clustering is an unsupervised
learning task that is utilized to discover hidden patterns in
the dataset that can't be classified appropriately and
plainly. It groups the dataset in the form of clusters having
similar characteristics. There are various clustering
paradigms which are applied on the dataset depending on
expected cluster characteristics. These algorithms are
applied based on the data type of attributes, the
algorithm’s complexity, and aptness for a specific
grouping. Clustering is performed for various purposes.
This paper attempts to study different clustering
algorithms that are categorized into various clustering
paradigms. The algorithms are reviewed and analyzed on
various parameters. It also presents a comparison table
based on efficiency to handle high dimensional data,
handle outliers and noise, scalability, sensitiveness to the
input sequence, space and time complexities.
SMART DAM SYSTEM
Authors: Wankhade Vishal , Thakker Aniket , Vakte Dishant , Motekar Harish
Published: October 2021

With increase in global warming and ever
changing temperature the rate of water in dam and
temperature affects millions of people and damages the
economy if any incident were supposed to happen due to
human error so with the help of our automated dam
system we have very efficiently solved it with the help of
temperature sensor and advanced Ultrasonic sensor we
have automated the dam gate opening process so that the
gate of dam is automatically opened when there are
chances of dam being overflowed or damaged. Using
ultrasonic sensor and a temperature system to
simultaneously support the decision of dam door
functionality helped in overcoming accidental and falsetriggered data. Using these two in co-relation makes
system less prone to error and increases the efficiency by
multiple times.
Synthesis and structure of macrocyclic dinickel(II) complex with 5-(4-pyridyl)tetrazolate as coligand
Authors: Voitekhovich Sergei V. , Kersting Berthold , Ivashkevich Oleg A.
Published: October 2021

The dinuclear nickel(II) complex [Ni2LmClO4] + , where Lm represents a 24-membered macrocyclic hexaaza-dithiophenolate ligand, reacts with 5-(4-pyridyl)tetrazole (PyrCN4H) to give the dinuclear complex [Ni2Lm(PyrCN4)]+ . The new complex was both isolated as perchlorate or tetraphenylborate salts and characterised by elemental analysis and IR spectroscopy. The structure of [Ni2Lm(PyrCN4)]BPh4 ⋅ MeCN was determined by single crystal X-ray diffraction, showing that tetrazolate units are in a N2,N3-bridging mode to generate dioctahedral N3Ni(µ-S)2(µ-N4CPyr)NiN3 core.
Complexes of clay minerals of quaternary sediments in canyon-cone system of the river Shahe (Black Sea)
Authors: Yuanqiu Ye. , Luksha V. L.
Published: October 2021

A distribution of clay minerals in Quaternary sediments are revealed in the sedimentary system canyon — deep-water cone of the Shahe river in the Black sea. It is established that the ratio of illite, chlorite, smectite and kaolinite sustained by area and section is determined by the transfer of sedimentary material by turbidity flows through the canyon with the formation of a unified mineralogical province.
Technogenic transformation of the ecological functions of abiothic spheres of the earth under the influence of military activities
Authors: Trofimov V. T. , Kharkina M. A. , Zhigalin A. D. , Baraboshkina T. A.
Published: October 2021

Military activities lead to the transformation of all the ecological functions of the abiotic spheres of the Earth both in peace and wartime. The typification of the consequences of ecological situation changes caused by the development of the ecological functions of the abiotic spheres of the Earth under testing of weapons, rocket and space techniques and during conduction of hostilities are presented.
Thermodynamic model of chemical re-magnetization on the example of Girvas paleovolcano of the Onega structure of Karelian craton
Authors: Bychkov A. Yu. , Popova Yu. A. , Kikvadze O. E. , Lubnina N. V.
Published: October 2021

Volcano Girvas is a complexly constructed volcano complex of the Yatuli age. Apparently, it is a shield lava volcano, which was probably one of the supply channels of the vast lava field of the western Prionezhie region within the Girvas volcanic zone. Despite the fact that the Girvassky volcano is bare only fragmentary, the structure of the current is perfectly preserved in the rocks, allowing to reconstruct the direction of flow. Among these rocks, there is a zone of postvolcanic hydrothermal changes in the rocks, consisting mainly of nesting and veined tourmalization and silicification, as well as subsequent epidotization, sulfidization, chloritization and albitization. The zones of secondary changes are confined to faults, while their spatial-temporal correlation remains unclear. Reconstruction of the geological structure showed that there were two main processes at the Girvasa volcano: 1) pneumatolysis of type due to magmatic gases separated from gabbro-dolerite sills, 2) heating and circulation of exogenous waters with formation of near propylites. Based on the proposed scheme, thermodynamic modeling was performed.
Maastrichtian-Danian boundary deposits of the Central Crimea: new data on calcareous nanoplankton
Authors: Lygina E. A. , Ustinova M. A. , Gabdullin R. R. , Reentovich A. V.
Published: October 2021

Information on the structure features as well as new data on the distribution of calcareous nanoplankton (NP) from the Cretaceous-Paleogene boundary deposits of the Central Crimea is given. There is a rich complex of Cretaceous NP in both Maastrichtian and Danian rocks. Danian NP is sparse, poor preserved or absent. Lower Maastrichtian species Tranolithus orionatus (=Tranolithus phacelosus Stover) unknown in the Upper Maastricht of European sections and described only from the Upper Maastricht of the South-West of Tunisia is noted in Upper Maastrichtian rocks of studied area. Zones NP2–NP4 were determined in Danian rocks. The question of paleogeography is also concerned.
Faults in the quarterly deposits in Northern Ladoga region as indicator of seismotectonic processes related to neotectonic activation of Precambrian structural plan
Authors: Agibalov A. O.
Published: October 2021

Faults in the quarterly deposits established during field investigations indicate that seismic events with magnitude of no less than 5 occurred in the Northern Ladoga region during neotectonic time. Computer modeling has shown that the modern seismicity of this territory is associated with the neotectonic activation of Precambrian disjunctive structures in conditions of NW compression. Relief analysis allows us to distinguish faults limiting the basin of the Ladoga Lake, which belongs to active neotectonic structures.
Educational standards of the geological faculty of Moscow State University: The search for answers to the challenges of our time
Authors: Pushcharovsky D. Y. , Stepanov P. Y. , Nikolaeva S. K. , Krylov O. V.
Published: October 2021

Outlines the history of the formation of layered geological formations at MSU. The features of independently established educational standards and curricula at the geological faculty of Moscow state University are considered. The difficulties encountered in the formation of the structure of educational standards, curriculum development and transition to the system of credits are analyzed. Questions of formation of structure of educational process in a magistracy on the basis of master's programs, instead of on profiles of preparation, as in a bachelor's degree are brought up.
Potencial of rock-magnetic methods in paleoecological reconstructions: case study of Mikhailovtsement reference section (Ryazan region)
Authors: Stepanov I. A. , Kazansky A. Yu. , Kiselev D. N. , Kosareva L. R. , Rogov M. A. , Tesakova E. M. , Shchepetova E. V. , Shurupova Ya. A.
Published: October 2021

On the basis of detailed, combined rock-magnetic, lithological, and micropaleontological study of the Mikhailovtsement section of the Moscow syneclise (Ryazan region), the fluctuations in Central Russian Sea level in Callovian–Early Oxfordian were reconstructed. According to the variations of rock-magnetic parameters over the section, seven rock-magnetic intervals were established which correspond to different stages of basin evolution. These stages are compared with sea level fluctuations established on the basis of changes in the lithology of rocks and the ostracod complexes. In general, the nature of sea level change in Callovian–Oxfordian, revealed by combination of the methods during the study of Mikhailovtsement section coincides with global trend.
Comparative analysis of the structure of the tectonosphere of the Conrad and Afanasy Nikitin Rises by geophysical data (the Indian Ocean)
Authors: Shaikhullina A. A. , Dubinin E. P. , Bulychev A. A. , Gilod D. A.
Published: October 2021

A two-dimensional density modeling is performed for profiles crossing the seamounts of the Conrad Rise (Lena, Ob and Marion Dufresne), which are located in the southwestern part of the Indian Ocean and the Afanasy Nikitin Rise, which is located in the central part of the Indian Ocean. According to the assumptions of a number of researchers, the seamount Marion Dufresne and the Afanasy Nikitin Rise were formed as a result of the hotspot 83–73 million years ago. The results of two-dimensional density modeling showed a similar structure of the crust and lithosphere, which confirms the probability of their formation 83–73 million years ago as a result of the action of a single hotspot. Also on the basis of the obtained results, the assumption is confirmed that the seamounts Lena and Ob of the Conrad Rise were formed afterwards due to the continuation of the action of the hotspot under the Antarctic Plate.
Variations of Ta and Nb contents in peraluminous granite high-fluorine melt in connection with association of liquidus phases
Authors: Alferyeva Ya. O. , Gramenitskiy E. N. , Shchekina T. I. , Zinovyeva N. G.
Published: October 2021

At a temperature of 700 ᵒC, a pressure of 100 МPa, a water content of 10 wt.% аnd the addition of 1 wt.% Ta and Nb, a series of experiments were carried out in the peraluminous part of the haplogranite high fluorine system SiO2-Al2O3-Na2O-Li2O-F. Two types of equilibrium phase associations were obtained: 1) an aluminosilicate melt — topaz — quartz — an ore Ta-Nb mineral, 2) an aluminosilicate melt — a salt alumina fluorine melt–cryolite. The maximum content of Ta and Nb in the silicate melt of the first type is about 0,29 and 0,35 wt.%, respectively. In the silicate melt of the second type, the content of these metals increases almost fourfold (1,27 and 1,21, respectively), without reaching the saturation of the Ta-Nb ore phase. A similar change in the total amount of Ta and Nb in genetically related highly evolved rocks is observed for topaz and cryolite granite massifs in the province of Piting (Brazil).
Global factors of lead-zinc ore formation
Authors: Dergachev A. L.
Published: October 2021

Tectonic evolution of the Earth is a principle global factor responsible for uneven distribution of lead and zinc reserves in geological time. Cyclic changes in productivity of lead-zinc ore-formation processes resulted from periodical amalgamation of most blocks of continental crust, formation, stabilization and final break-up of supercontinents. Many features of age spectrums of lead and zinc reserves are caused by gradual increase of volume of continental crust resulting from accretion of island arcs to ancient cratons, widening of distribution of ensialic environments of ore-formation and increasing role of continental crust in magmatic processes.
Isotopic composition and geochemical features of ores of Dzhusa pyrite-polymetallic deposit (South Urals)
Authors: Yartsev E. I. , Vikentyev I. V. , Eremin N. I.
Published: October 2021

The sulfur isotopic composition was studied for the main morphological types and generation of sulfides composing the ore of the Dzhusinsky deposit, and the content of trace elements was analyzed using the highly sensitive method of mass spectrometry with inductively coupled plasma and laser sampling (LA-ICP-MS). Both types of studies were performed for ore deposits for the first time. According to the geochemistry of sulfur isotopes, its deep magmatic source was reconstructed, which made a predominant contribution to the ore-forming fluid. Using the modules of the STATISTICA, correlations were calculated and the patterns of distribution of micro impurities in sulfide minerals were revealed.
Separation of frequency-dependent scattering and inelastic absorption by waveform inversion of VSP data constrained by well logs
Authors: Pirogova A. S.
Published: October 2021

The paper presents an approach to estimation of frequency-dependent attenuation of seismic waves propagating in the earth subsurface. The approach is based on the waveform inversion of vertical seismic profiling data acquired in a borehole. Incorporation of well log data (in particular, sonic and density logs) in the forward modelling routine allows for separation of two factors that cause frequency-dependent seismic attenuation. In particular, the inversion facilitates separation of 1D scattering versus inelastic absorption in the horizontally layered subsurface.
New sedimentological, bio-magnetostratigraphic and palynologic data on the Upper Cretaceous of “Alan-Kyr” (Central Crimea)
Authors: Guzhikov A. Yu. , Aleksandrova G. N. , Baraboshkin E. Yu.
Published: October 2021

In this article there are the results of sedimentological, palynological and paleomagnetic studies of upper Cretaceous in Alan-Kyr section (Central Crimea). The nomenclature of rocks was specified, and their deep-water genesis was justified. According to palynologic data, the age of sediments is estimated as late Campanian, in the lower part of the section palynomorphs were not found. In the lower part of the section there was established a reverse polarity magnetozone — probable analogue of C33r magnetic chron, which base should be desirable to use as a primary attribute to determine the lower border of Campanian stage in the section according to Wolfring’s recommendation [Wolfgring et al., 2018]. The received data found a significant divergence microfaunistic dating of the section, conducted before [Bragina et al., 2016].
Features of the microcomponent composition of pore solutions of rocks of the Bazhenov Formation in Western Siberia
Authors: Kireeva T. A. , Bychkov A. Yu. , Zubkov M. Yu.
Published: October 2021

The results of experimental studies of the macro- and microcomponent composition of pore solutions of bituminous clay-siliceous rocks of the Bazhenov Formation (BS) of Western Siberia, containing up to 12.63% Corg (“normal rocks”), as well as silt-sandstones from the “anomalous” section are presented. BS with a Corg content of up to 0.63% (“abnormal” rocks) obtained on the basis of a study of aqueous extracts from core samples. It has been established that pore solutions of “normal” BS rocks have a sulfate-bicarbonate-sodium composition, and “abnormal” ones have a hydrocarbonate-sodium chloride composition. In pore solutions of both “normal and“ abnormal ”rocks relative to ocean water, the following were noted: a) concentration of Mn, Co, Ni, Cu, Zn, Mo, Sb, Cd, Ba, V, Cr of various degrees of intensity; b) increased content of Cs, Pb, Ti only in pore solutions of “abnormal” rocks; c) reduced content of Li, B, Rb, Sr. A direct relationship was found between the contents of Li, B, Ba, Sr, U, Mo, Cd, Sb, and Ni with the content in the Corg rock. For V, Cs, Sb, Rb, Ti, Mn in pore waters, the relationship with the amount of Corg in the rocks is close to the inverse relationship. In the pore solutions of “normal” BS rocks, the Ba content is equal to or higher than the Sr content, which is anomalous with respect to the stratal waters of most oil fields and ocean water and, apparently, is associated with the peculiarities of the accumulation of organic clay deposits, since in “anomalous” rocks The BS content of Sr is two times higher than the Ba content, which is closer to the usual for most natural waters.
Geology, formation conditions, and ore content of the Turgoyak granite massif and carbonaceous deposits of its western framing (South Ural)
Authors: Snachev A. V. , Snachev V. I. , Romanovskaya M. A.
Published: October 2021

The article describes the geological structure of the Turgoyak granitoid massif (γϬС1–2ts), Urenga (RF2ur) and Uytash (RF3uš) suites. In the Late Vendian time the rocks first experienced regional metamorphism under the conditions of the cummingtonite-amphibolite facies at a temperature of 550–595 °C and a pressure of 250400 МПа, and then in local areas — diaftoresis (T=520530 °C and P=130170 МПа). During the formation of the Turgoyak massif (T=770810 °C and P=210250 МПа), the rocks of the Urengin and Uytash suites were subjected to contact metamorphism. This metamorphic processes made the black shale gold to remove from the black shale zone of the amphibole-hornfels facies and caused its redeposition within the albite-epidote-hornfly zone.
Mineralogical and geochemical features of mantle xenoliths from diamond bearing kimberlites of China and Yakutia
Authors: Vorobei S. S. , Garanin V. K. , Minervina E. A. , Posukhova T. V. , Sheng Xia Wei
Published: October 2021

Xenoliths from the Mir pipe and from Shandong and Liaoning provinces were studied according to electron microbeam analysis and ICP-MS. Their mineralogical, geochemical and genetic features are revealed. Minerals of diamondiferous paragenesis were established in xenoliths of the Mir pipe, but not in xenoliths of China. All xenoliths have secondary changes. They are stronger in the xenoliths of China. The distribution of REE shows the involvement of subduction processes in the formation of xenoliths from the Mir pipe. They are not found in xenoliths from China; the influence of metasomatism is clearly manifested in them. РТparameters were calculated: Т=600700 °С, Р=22,5 GPa. They do not correspond to mantle settings and reflect the conditions of metasomatic processes.
Geophysical methods for determining the reservoir properties of complexly constructed Lower and Middle Jurassic deposits within the oil-gas fields of the Ob River Region
Authors: Shelepov V. V. , Tyukavkina O. V.
Published: October 2021

This paper discusses the use of geophysical well logging for the interpretation of complex structure oil-saturated intervals of the Lower and Middle Jurassic horizons with high average number of permeable intervals, the content of minerals — semiconductors (pyrite, siderite, glauconite, et al.) for structuring a complex of geological and geophysical information and developing a researching methodology of areas with hard to recover reserves on example of deposits which was in operation for an extended period of time.
Reservoir quality assessing and petroleum potential of Nepa horizon in Lena-Tunguska basin
Authors: Sivkova E. D. , Sautkin R. S.
Published: October 2021

Reservoir layers were located within the Nepa horizon according to the log data interpretation of 26 wells. Porosity and gas saturation were calculated within these layers. The research provides an opportunity to determine reservoir potential of sediments and to identify further research lines.
Distribution of elements in the vertical cut of bottom sediments of the Black sea
Authors: Nemchenko E. I. , Lipatnikova O. A. , Demina L. L. , Kravchishina M. D. , Lubkova T. N.
Published: October 2021

The trace element composition of the vertical section of the Black Sea bottom sediments was studied. Based on the calculated enrichment factors relative to the average composition of the earth’s crust, it was shown that a lithogenic source is predominant for most trace elements. Significant enrichment was obtained for Ca and Sr (due to bioaccumulation) and for S, As and Mo (as a result of hydrogen sulfide contamination processes and the influence of mud volcanoes). A specific conditions of sedimentation were estimated based on the elements’ ratios which indicate: a presence of exhalation components in the deposits (Fe+Mn/Ti), a range of transport of terrigenous material (Ti/Zr) were estimated; paleoreconstruction of salinity (Corg/S), as well as redox conditions in the bottom water layer (Mn/Fe, Mo/Mn, V/(V+Ni), V/Mn).
The dynamic of parameters for active layer
Authors: Uvarova A. V. , Komarov I. A. , Isaev V. S. , Tyurin A. I. , Bolotuk M. M.
Published: October 2021

The paper presents methods and results of experimental studies of the dynamic of the temperature regime, the thickness of active layer and rock heave deformation over a five-year field observations period, as well as the results of predictive modeling of these processes on the Moscow State University Zvenigorod Biological station. The results of comparison of field data with the calculated characteristics based on numerical modelling of heave process are presents.
Applying of dynamic acoustic signal attributes for evaluation of the contact between pile and soils
Authors: Kapustin V. V. , Churkin A. A.
Published: October 2021

The low-strain impact method is one of the most commonly used non-destructive geophysical methods in pile integrity testing. Data analysis of the low-strain method in the frequency domain allows the researcher to get additional information about the studied foundation. The authors of the article propose a methodology for assessing the contact of piles with soils based on an analysis of the dynamic attributes of the frequency response. Conclusions drawn from using the above-described method can be used by engineers to study piles quality and to plan direct static load tests to determine the bearing capacity of piles.
Neotectonic vertical movements of the South Sikhote-Alin and characteristics of self-similarity of the stream network
Authors: Simonov D. A. , Zakharov V. S. , Gilmanova G. Z. , Didenko A. N.
Published: October 2021

Morphostructural analysis of the relief and fractal analysis of the stream network of the South of the Sikhote-Alin orogenic belt were carried out. The formation of the relief at the neotectonic stage occurred in several stages, which was reflected in the stream network pattern: 1) during pre-Oligocene time there was a general uplift of Sikhote-Alin; 2) in the Pliocene there was an activation of vertical neotectonic movements, most intense to the East of the Central Sikhote-Alin fault and synchronous whith basalt volcanism; 3) in the Pleistocene vertical movements of significant amplitude did not occur, at this time the modern erosion-denudation relief of the region was formed; 4) at the end of the Pleistocene and in Holocene there was a slight activation of vertical movements to the East of the Central Sikhote-Alin fault, which was reflected in the peculiarities of residual relief. Comparison of morphological and fractal analysis results showed, that the maximum of complex parameter of self-similarity PRNS coincide with the areas of greatest increments in elevation and the minima is the smallest increment of relief or whith the areas whith most significant erosion. In regions with the stage character of neotectonic development during fractal analysis of stream network it is necessary to consider additional factors due to the peculiarities of development of the stream network at each stage of development, and conservative of its pattern, reflecting features of the development of the relief in different stages.
Early Permian organogenic buildups within the Northern part of Timan-Pechora basin
Authors: Evdokimov N. V. , Zhemchugova V. A.
Published: October 2021

Lower Permian organogenic buildups within the Northern part of Timan-Pechora basin are mounds-type structures. They are characterized by an extremely irregular distribution of reservoirs which are linked to facial zones and genetic features of the deposits. Two types of buildups were distinguished qualified as microbial and skeletal mounds formed by different paleo-communities of benthic organisms. The composition and textural-structural features of prevailing limestones within these buildups there is a key to understand the distribution of reservoirs within the area of study.
Hydrogeochemical features of the groundwater in the Bodrak river basin (Kachinskoe Uplift Mountain Crimea)
Authors: Kayukova E. P. , Baraboshkina T. A. , Filimonova E. A.
Published: October 2021

The hydrogeochemical composition of groundwater in the Bodrak River basin (area of the geological practical studies and field works for students of SPbU, Lomonosov MSU, Dubna and Voronezh Universities) was investigated. The study determined role of lithology in the hydrochemical composition of groundwater and surface waters of the region. Three hydrochemical generations of groundwater have been identified by statistical analysis, geochemical features of groundwater in the region have been revealed, stable natural association of chemical elements in the groundwater of the Bodrak River has been obtained: Ba(2,0–58,2)–B(1,1–10,3)–Ag(3,2–8,6)–Sr(1,6–8,4)–Sn(3,4–4,9). The study analyzed the intensity of water migration of chemical elements in the groundwater and river waters of the Bodrak River, and the variability of the water migration coefficient was obtained along the river.
Regularities of fluorine leaching from the rocks by organic acids
Authors: Savenko A. V. , Savenko V. S.
Published: October 2021

Experiments on fluorine leaching from the rocks (alkaline agpaitic granite, dacite, and feldspathic-quartzy aleurite) by 0.005 M solutions of acetic, tartaric, citric, and oxalic acids were carried out. The previously revealed fact of decrease in the fluorine leaching by organic acids as compared with that by distilled water with an increase in acidity of solutions in the pH range from 6.3 to 3.5 is confirmed. According to the leaching ability in relation to distilled water, organic acids are formed a number: oxalic > citric > acetic ≈ tartaric. It is assumed that decrease in pH leads to sorption of fluorides as a result of the replacement of adsorbed hydroxyl ions. From this point of view, less intensive (compared with distilled water) fluorine leaching in acidic medium can be associated with sorption immobilization of fluoride ions in the solid phase. A positive correlation between amounts of leached fluorine and magnesium indicates the existence of a certain common, as well as not established mechanism for transition of these elements from minerals to aqueous solution.
The Twenty-five-year activity results of the Interdisciplinary scientific workshop-conference “Earth Planet System” at the geological faculty of the Lomonosov Moscow State University
Authors: Syvorotkin V. L.
Published: October 2021

At the current level of differentiation of sciences, we could compare achievements of each of them with a quote taken out of context. We know such a procedure holds a high risk, since it could change scientific ideas and meanings fundamentally. In the framework of epistemology, context is the totality of the results of all sciences, i.e. all modern knowledge about the object of study. In the framework of epistemology, context is the totality of the results of all sciences, i.e. all modern knowledge about the object of study; in our case we're talking about knowledge of planet Earth. To some extent mitigate the inevitability of modern sciences separation from this context, the Interdisciplinary Workshop (conference) “Earth Planet System” has been held for 25 years at the Geological Faculty of Lomonosov Moscow State University. In the framework of this Workshop, representatives of numerous sciences and humanities discuss a wide range of problems of life on our planet.
Sheet Turning System Design and Prototype Manufacturing Suitable for Line Systems
Authors: Aydemir Fatih , Ulu Ali
Published: October 2021

In the sectors where sheet metal processing machines are used, especially in line systems where punch, shears and panel bender machines are used together, sometimes it is necessary to rotate the sheet materials coming out of the punch machine before bending when they are automatically fed into the panel bender machine. In fully automatic bending lines, an automatic sheet turning system was needed in order to perform the rotation process independently of the operator. With the turning system, which is the subject of the project, it is activated in cases where materials such as stainless steel with a film coated on one side need to be rotated after cutting, and the sheet material is safely transmitted to the bending area. The system, whose prototype production has been completed, is also used together with punch, laser and shear combinations of panel bending machines, which are used in sectors such as elevator manufacturing, steel door manufacturing, panel manufacturing, kiosk and control panel manufacturing, cabinet and case manufacturing, industrial cooling systems, industrial kitchen manufacturing.
Peyzaj Alanlarında Bulaşıcı Hastalıklar Yönünden Oluşabilecek Risk Faktörlerini En Aza İndirmeye Yönelik Fonksiyonel Donatı Elemanları Tasarlanması
Authors: Ekiz Nazlı , Sağlık Alper
Published: October 2021

Dünya üzerinde birçok canlı birbiriyle etkileşim içinde bulunmaktadır. Bu etkileşim canlılar arasında zaman zaman fayda sağlarken bazı durumlarda zarar oluşturabilir. Bu zararlardan biri de bulaşıcı hastalıklardır. Bulaşıcı hastalıklar çok eski zamanlarda savaşlar ve kıtlıklar ile yayılmaya başlamıştır. Yaşandığı dönemden günümüze kadar büyük tahribatlarla süregelmiştir. Bulaşıcı hastalıklar için gerekli önlemlerin alınmaması sonucunda bu durum salgın haline dönüşebilir. Günümüzde yaşanan salgın, şehir düzenlemeleri ile ilgili bazı şeylerin daha çok farkına varmamıza neden olmuştur. Yaşanan salgın nedeniyle tüm dünyanın karantinaya alınması sonucu insanlar birçok yönden olumsuz etkilenmiştir. Bu nedenle en önemli konulardan biri, dış mekanlar tasarlanırken insanları tamamen kısıtlamadan daha güvenli alanlar oluşturmaktır. Peyzaj alanları ve donatı elemanlarının bu duruma uygun tasarlanması ile ihmal durumları da dahil bütün riskler en aza indirgenmektedir. Bu çalışma ile bulaşıcı hastalıklar yönünden oluşabilecek risk faktörlerini en aza indirerek daha güvenli alanlar oluşturmak amacıyla yeni donatı elemanları tasarlanmıştır.
GEDpm-cg: Genome Editing Automated Design Platform for Point Mutation Construction in Corynebacterium glutamicum
Authors: Yang Yi , Mao Yufeng , Liu Ye , Wang Ruoyu , Lu Hui , Li Haoran , Luo Jiahao , Wang Meng , Liao Xiaoping , Ma Hongwu
Published: October 2021

Advances in robotic system-assisted genome editing techniques and computer-aided design tools have significantly facilitated the development of microbial cell factories. Although multiple separate software solutions are available for vector DNA assembly, genome editing, and verification, by far there is still a lack of complete tool which can provide a one-stop service for the entire genome modification process. This makes the design of numerous genetic modifications, especially the construction of mutations that require strictly precise genetic manipulation, a laborious, time-consuming and error-prone process. Here, we developed a free online tool called GEDpm-cg for the design of genomic point mutations in C. glutamicum. The suicide plasmid-mediated counter-selection point mutation editing method and the overlap-based DNA assembly method were selected to ensure the editability of any single nucleotide at any locus in the C. glutamicum chromosome. Primers required for both DNA assembly of the vector for genetic modification and sequencing verification were provided as design results to meet all the experimental needs. An in-silico design task of over 10,000 single point mutations can be completed in 5 min. Finally, three independent point mutations were successfully constructed in C. glutamicum guided by GEDpm-cg, which confirms that the in-silico design results could accurately and seamlessly be bridged with in vivo or in vitro experiments. We believe this platform will provide a user-friendly, powerful and flexible tool for large-scale mutation analysis in the industrial workhorse C. glutamicum via robotic/software-assisted systems.
Diagnostic Role of Extracellular Vesicles in Cancer: A Comprehensive Systematic Review and Meta-Analysis
Authors: Liu Shu-ya , Liao Yin , Hosseinifard Hossein , Imani Saber , Wen Qing-lian
Published: October 2021

Background: Cancer-derived extracellular vesicles (EVs) are regarded to have significant function in most steps during cancer progression. This meta-analysis aims to investigate the accuracy of EVs as a biomarker in cancer diagnosis.

Methods: The diagnostic efficacy of EVs for different cancers was assessed using pooled sensitivity and specificity, diagnostic odds ratio (DOR), and overall area under the curve (AUC) of the summary receiver operating characteristic (SROC). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were verified to estimate the diagnostic efficacy of EV at a clinical level.

Results: In all, 6,183 cancer patients and 2,437 healthy controls from 75 eligible studies reported in 42 publications were included in the study. The overall pooled sensitivity, specificity, PLR, NLR, and DOR were 0.62 (95% CI: 0.60–0.63), 0.76 (95% CI: 0.75–0.78), 3.07 (95% CI: 2.52–3.75), 0.34 (95% CI: 0.28–0.41), and 10.98 (95% CI: 7.53–16.00), respectively. Similarly, the AUC of the SROC was 0.88, indicating a high conservation of EVs as an early diagnostic marker. Furthermore, subgroup analysis suggested that the use of small EVs as a biomarker was more accurate in serum-based samples of nervous system cancer (p < 0.001). As a result, ultracentrifugation and quantification and size determination methods, such as Western blotting and ELISA were the most reliable identification methods for EV detection. We also indicated that increased secretion of EVs made them a capable biomarker for diagnosing cancer in elderly European individuals.

Conclusions: Our study provides evidence that EVs are a promising non-invasive biomarker for cancer diagnosis. Well-designed cohort studies should be conducted to warrant the clinical diagnostic value of EVs.
Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway
Authors: Li Balun , Cheng Xuedi , Aierken Aili , Du Jiaxin , He Wenlai , Zhang Mengfei , Tan Ning , Kou Zheng , Peng Sha , Jia Wenwen , Tang Haiyang , Hua Jinlian
Published: October 2021

Abundant evidence proves the therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) in the treatment of diabetes mellitus. However, the problems have not been solved that viability of ADMSCs were inconsistent and the cells quickly undergo senescence after in vitro cell culture. In addition, the therapeutic effect of ADMSCs is still not satisfactory. In this study, melatonin (MLT) was added to canine ADMSC culture medium, and the treated cells were used to treat type 2 diabetes mellitus (T2DM). Our research reveals that adding MLT to ADMSC culture medium can promote the viability of ADMSCs. This effect depends on the binding of MLT and MLT receptors, which activates the transforming growth factor β (TGF-β) pathway and then changes the cell cycle of ADMSCs and improves the viability of ADMSCs. Since ADMSCs were found to be used to treat T2DM by anti-inflammatory and anti-endoplasmic reticulum (ER) stress capabilities, our data demonstrate that MLT augment several effects of ADMSCs in remission hyperglycemia, insulin resistance, and liver glycogen metabolism in T2DM patients. This suggest that ADMSCs and MLT-ADMSCs is safe and vabulable for pet clinic.
Genes and miRNAs as Hurdles and Promoters of Corticospinal Tract Regeneration in Spinal Cord Injury
Authors: Boido Marina , Vercelli Alessandro
Published: October 2021

Spinal cord injury (SCI) is a devastating lesion to the spinal cord, which determines the interruption of ascending/descending axonal tracts, the loss of supraspinal control of sensory-motor functions below the injured site, and severe autonomic dysfunctions, dramatically impacting the quality of life of the patients. After the acute inflammatory phase, the progressive formation of the astrocytic glial scar characterizes the acute-chronic phase: such scar represents one of the main obstacles to the axonal regeneration that, as known, is very limited in the central nervous system (CNS). Unfortunately, a cure for SCI is still lacking: the current clinical approaches are mainly based on early vertebral column stabilization, anti-inflammatory drug administration, and rehabilitation programs. However, new experimental therapeutic strategies are under investigation, one of which is to stimulate axonal regrowth and bypass the glial scar. One major issue in axonal regrowth consists of the different genetic programs, which characterize axonal development and maturation. Here, we will review the main hurdles that in adulthood limit axonal regeneration after SCI, describing the key genes, transcription factors, and miRNAs involved in these processes (seen their reciprocal influencing action), with particular attention to corticospinal motor neurons located in the sensory-motor cortex and subjected to axotomy in case of SCI. We will highlight the functional complexity of the neural regeneration programs. We will also discuss if specific axon growth programs, that undergo a physiological downregulation during CNS development, could be reactivated after a spinal cord trauma to sustain regrowth, representing a new potential therapeutic approach.
The APC/CFZY–1/Cdc20 Complex Coordinates With OMA-1 to Regulate the Oocyte-to-Embryo Transition in Caenorhabditis elegans
Authors: Hu Yabing , Hu Xuewen , Li Dongchen , Du Zhenzhen , Shi Kun , He Chenxia , Zhang Ying , Zhang Donglei
Published: October 2021

During oocyte maturation and the oocyte-to-embryo transition, key developmental regulators such as RNA-binding proteins coordinate translation of particular messenger RNA (mRNAs) and related developmental processes by binding to their cognate maternal mRNAs. In the nematode Caenorhabditis elegans, these processes are regulated by a set of CCCH zinc finger proteins. Oocyte maturation defective-1 (OMA-1) and OMA-2 are two functionally redundant CCCH zinc finger proteins that turnover rapidly during the first embryonic cell division. These turnovers are required for proper transition from oogenesis to embryogenesis. A gain-of-function mutant of OMA-1, oma-1(zu405), stabilizes and delays degradation of OMA-1, resulting in delayed turnover and mis-segregation of other cell fate determinants, which eventually causes embryonic lethality. We performed a large-scale forward genetic screen to identify suppressors of the oma-1(zu405) mutant. We show here that multiple alleles affecting functions of various anaphase promoting complex/cyclosome (APC/C) subunits, including MAT-1, MAT-2, MAT-3, EMB-30, and FZY-1, suppress the gain-of-function mutant of OMA-1. Transcriptome analysis suggested that overall transcription in early embryos occurred after introducing mutations in APC/C genes into the oma-1(zu405) mutant. Mutations in APC/C genes prevent OMA-1 enrichment in P granules and correct delayed degradation of downstream cell fate determinants including pharynx and intestine in excess-1 (PIE-1), posterior segregation-1 (POS-1), muscle excess-3 (MEX-3), and maternal effect germ-cell defective-1 (MEG-1). We demonstrated that only the activator FZY-1, but not FZR-1, is incorporated in the APC/C complex to regulate the oocyte-to-embryo transition. Our findings suggested a genetic relationship linking the APC/C complex and OMA-1, and support a model in which the APC/C complex promotes P granule accumulation and modifies RNA binding of OMA-1 to regulate the oocyte-to-embryo transition process.
Neutrophils and Lymphocytes Can Help Distinguish Asymptomatic COVID-19 From Moderate COVID-19
Authors: Gu Xuefeng , Sha Ling , Zhang Shaofeng , Shen Duo , Zhao Wei , Yi Yongxiang
Published: October 2021

Introduction

Asymptomatic coronavirus disease 2019 (COVID-19) and moderate COVID-19 may be the most common COVID-19 cases. This study was designed to develop a diagnostic model for patients with asymptomatic and moderate COVID-19 based on demographic, clinical, and laboratory variables.

Methods

This retrospective study divided the subjects into 2 groups: asymptomatic COVID-19 (without symptoms, n = 15) and moderate COVID-19 (with symptoms, n = 57). Demographic characteristics, clinical data, routine blood tests, other laboratory tests, and inpatient data were collected and analyzed to compare patients with asymptomatic COVID-19 and moderate COVID-19.

Results

Comparison of the asymptomatic COVID-19 group with the moderate COVID-19 group yielded the following results: the patients were younger (P = 0.045); the cluster of differentiation (CD)8+ (cytotoxic) T cell level was higher (P = 0.017); the C-reactive protein (CRP) level was lower (P = 0.001); the white blood cell (WBC, P < 0.001), neutrophil (NEU, P = 0.036), lymphocyte (LYM, P = 0.009), and eosinophil (EOS, P = 0.036) counts were higher; and the serum iron level (P = 0.049) was higher in the asymptomatic COVID-19 group. The multivariate analysis showed that the NEU count (odds ratio [OR] = 2.007, 95% confidence interval (CI): 1.162 - 3.715, P = 0.014) and LYM count (OR = 9.380, 95% CI: 2.382 - 36.934, P = 0.001) were independent factors for the presence of clinical symptoms after COVID-19 infection. The NEU count and LYM count were diagnostic predictors of asymptomatic COVID-19. This diagnostic prediction model showed high discriminatory power, consistency, and net clinical benefits.

Conclusions

The proposed model can distinguish asymptomatic COVID-19 from moderate COVID-19, thereby helping clinicians identify and distinguish patients with potential asymptomatic COVID-19 from those with moderate COVID-19.