bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional outcome of the elbow in toddlers with transphyseal fracture of the distal humerus treated surgically
Authors: Zhou W. , Canavese F. , Zhang L. , Li L.
Published: January 2019

Purpose To quantitatively evaluate the upper extremity and elbow function with the Mayo Elbow Performance Score (MEPS) in children with transphyseal fracture of the distal humerus (TFDH) treated surgically. Methods During the period between 2005 and 2015, a total of 16 patients (ten male, six female) met the inclusion criteria. Mean age at the time of injury was 18 months (11 to 37) and mean follow-up was 42.3 months (6 to 98). Based on a modified version of Delee's classification (Group A to C), the clinical and radiographic outcome of TFDH in toddlers treated surgically were retrospectively evaluated. Results Mean humeral-ulnar (HU) angle of the injured and non-injured side was 1.2° (-18° to 14°) and 8.8° (2° to 19°), respectively (p = 0.001). Closed and open reduction showed similar HU angle values (p = 0.682). Mean MEPS score of the injured and non-injured side was 85.5 points (70 to 95) and 95 points (90 to 100), respectively (p = 0.002). No significant association was identified between MEPS score and gender, side, age at trauma, direction of displacement, time from trauma to surgery, presence of ossified capitellum, type of surgery and type of fracture. Conclusion Functional outcome was generally good regardless of surgical procedure performed, closed or open and type of fracture according to modified Delee's classification. However, a residual cubitus varus was commonly observed among toddlers with transphyseal fractures of the distal humerus. Level of evidence Level IV – Therapeutic study
Effect of Extraction Methods on Flavoring Compounds and Antioxidant Activity of Extracts from Cinnamon (Cinnamomum cassia Blume)
Authors: Cha Jaeyoon , Kim Chong-Tai , Cho Yong-Jin
Published: January 2019

The interest in and development of healthy foods and nutraceuticals have increased because of the trend for a health-oriented society. Cinnamon is used as a food ingredient as well as a herbal medicine because of its functional properties. In this study, flavoring compounds and antioxidative activities of cinnamon extracts were investigated with different extraction solvents and extraction methods. The contents of flavoring compounds such as coumarin, cinnamic acid, cinnamaldehyde, and cinnamyl alcohol were investigated. The contents of courmarin, cinnamic acid, and cinnamylaldehyde in 70% ethanol extract were higher than those in hot water and subcritical water extracts. The contents of courmarin, cinnamic acid, and cinnamaldehyde in subcritical water extract were higher than those in hot water extract, whereas the content of cinnamyl alcohol was lower. DPPH scavenging activity increased with increasing concentration of the extracts, and the 70% ethanol extract showed the highest antioxidant activity. The ascorbic acid content of the 70% ethanol extract was largest in the antioxidative activity measurement by FRAP analysis. The ascorbic acid contents of the hot water and subcritical water extracts were similar.
Prevalence of gastrointestinal parasites in cattle and sheep in three municipalities in the Colombian Northeastern Mountain
Authors: Pinilla Leon Juan Carlos , Delgado Nelson Uribe , Florez Angel Alberto
Published: January 2019

Aim: The study was conducted to determine the prevalence of gastrointestinal (GI) parasites in cattle and sheep from three municipalities in the Colombian Northeastern Mountain.

Materials and Methods: Overall, 200 fecal samples were collected directly from the rectum in cattle and sheep. The presence of helminths eggs and coccidial oocysts in fecal samples was detected using McMaster and Dennis techniques. Identification of eggs or oocysts was done on the basis of morphology and size of the eggs or oocysts.

Results: The global prevalence of GI parasites was 56.3%. Regarding the prevalence by municipalities, there was no statistical association (p>0.05), indicating that the prevalence was similar in the three municipalities. The prevalence of parasitic infection was higher in sheep (63%) as compared to that of cattle (50.5%), but the difference was nonsignificant (p>0.05). The most prevalent parasites were Eimeria spp., Fasciola hepatica, and Strongylida order. Regarding the results for Eimeria spp., different degrees of positivity were observed, but there was no statistical association (p>0.05) with respect to the age group. Likewise, there was no statistical association (p>0.05) between the prevalence for Strongylida order and F. hepatica with respect to the age group.

Conclusion: Cattle and sheep in Colombian Northeastern Mountain were infected with helminths and coccidia. The prevalence values of GI parasites were moderate in both species warranting treatment. The presence of F. hepatica represents a risk factor to health public. Future studies are required to evaluate the parasitic dynamics throughout the year and the impact on animal production.
SEDIMENTARY FACIES AND HYDROCARBON RESERVOIR POTENTIAL OF SAND FLAT IN THE UPPER PART OF TAPAK FORMATION IN BANYUMAS AREA, CENTRAL JAVA
Authors: Rizal Yan , Santoso Wahyu Dwijo , Rudyawan Alfend , Tampubolon Ricky Adrian , Nurfarhan Affan Arif
Published: January 2019

The upper part of Tapak Formation in Kali Cimande consists of alternating sandstones, siltstone and mudstone. The alternating sequence showed a fining and thinning upward bedding pattern. The facies association of the alternation built up by sand flat facies, which characterized by medium sandstone, moderate sorted, with cross-lamination sedimentary structures and mostly on the top of sandstone layer found a bioturbation trace fossils (Skolithos). Mixed flat facies, which is characterized by an alternation of thin layered sandstones with mudstone and siltstone, with lenticular, wavy, and flaser sedimentary structures, contained many forms of bioturbation, such Planolites, Thallasinoides, Lockeia, and Ophiomorpha. Mud flat facies association, is characterized by a repeated of claystone with thin sandstone intercalation, where the ratio of clay content more than 95 % of the total layers, contained abundantly with trace fossil Lockeia. Upper Tapak Formation plays as moderate reservoir potential. The thick sandstone in sand flat facies with moderate to poorly sorted and moderate porosity is required to provide hydrocarbon flows in Banyumas Basin.Bagian atas Formasi Tapak di Kali Cimande terdiri dari perselingan batupasir-batulanau dan mudstone. Sekuen perselingan menunjukkan pola perlapisan menghalus dan menipis ke atas. Asosiasi fasies tersebut terdiri dari fasies sand flat, yang dicirikan oleh batu pasir sedang, pemilahan sedang, struktur sedimen silang-siur serta fosil jejak bioturbasi (Skolithos) pada bagian puncak kebanyakan lapisan batu pasir. Fasies mixed flat, dicirikan oleh perselingan batupasir berlapis tipis dengan mudstone dan batulanau, serta struktur sedimen lentikular, perlapisan bergelombang, dan flaser, mengandung banyak bioturbasi, seperti Planolites, Thallasinoides, Lockeia, serta Ophiomorpha. Asosiasi Fasies sand flat, dicirikan oleh perulangan batulempung dengan sisipan batupasir tipis, dengan kandungan lempung lebih dari 95% total lapisan, serta fosil jejak Lockeia yang melimpah. Formasi Tapak Atas berperan sebagai reservoir potensial sedang. Bagian batupasir tebal di fasies sand flat dengan pemilahan sedang hingga buruk dan porositas sedang diperlukan untuk menyediakan aliran hidrokarbon di Cekungan Banyumas.
Malassezia species: the underrated resident of human skin
Authors: Albanova V.
Published: January 2019

Malassezia spp. are lipophilic and lipidodependent fungi that are part of the microbiota of the normal human skin. Malassezia spp. exists in two forms – micelial and yeast. Remarkable progress has been made in our knowledge of this genus in skin diseases recently. Under favorable conditions (high sebum and sweat excretion, impaired skin barrier), Malassezia spp. can proliferate, turn from yeast to micelial form, invade epidermis and induce or aggravate skin diseases, such as pityriasis versicolor, seborrheic dermatitis, Malassezia folliculitis, atopic dermatitis, psoriasis, acne, rosacea and others.   Revealing of yeasts and positive related specific tests (IgE antibodies and positive skin tests in atopic dermatitis) helps to cope with exacerbation using antifungal therapy.
Polska Kronika Filmowa as a source for research on contemporary Polish architecture
Authors: Marciniak Piotr
Published: January 2019

The materials used by architectural historians to research the post-war period are very limited, and the available archive resources are incomplete and dispersed. In this context, of special significance are other forms of visual materials that documented the spatial reality of the communist period. Documentary films, and in particular the Polska Kronika Filmowa [Polish Film Chronicle] newsreel, can make an an important contribution to and a resource for historical research on contemporary Polish architecture. This text contains methodological reflections on the role of film studying the history of contemporary architecture. It describes the new research options, including the ability to recreate original spatial phenomena, and also the contemporary techniques and technology as well as the educational dimension of the Polish Film Chronicle. In this context, it is especially interesting to compare the documentary material from the Chronicle with other archival material, e.g. drawings, plans and photographs. This method provides an additional opportunity for a fuller and more objective recreation of space in 3D. This “reverse modelling” can be used to restore or preserve the original condition of structures, or even to rebuild ones no longer existing.
Cozy Homes? Rooms and apartments of the intelligentsia in Polish drama films, 1956–1970
Authors: Gierszewska Barbara Lena
Published: January 2019

The article presents the problems of private life of intellectuals in Poland “after Yalta” through the prism of the cinema. The biggest problem of people in the 1950s and 1960s was the lack of a satisfying home. The homes of young intellectuals shown in Polish films are the spectrum of dreams, most often impossible to achieve in real life. Apartments located in multi-family housing estates that immortalized in the Polish feature films between the years 1956–1970 are confirmation of the highest quality of Polish industrial design. Real people’s apartments were cramped, ugly, and primitive.
Film (de)construction of national identity. The case of Serbian films from the 1990s
Authors: Zvijer Nemanja
Published: January 2019

The article deals with the relation between films and the concept of the national identity. These issues are discussed on the example of Serbian cinema in the 1990s. Using Anthony Smith’s approach to the visual representation of national identity, the ways in which films in Serbia construct national identity is discussed. After that, several films are analyzed that critically question the concept of nationalism. This analysis demonstrates how ideology, in this particular case, nationalistic ideology, at the semantic level can be related to films, one of the most influential segments of popular culture.
Deviating memories: Armando Lulaj’s seriously playful excursions into Albania’s history
Authors: Grgic Ana
Published: January 2019

This paper examines how certain contemporary audio-visual works from post-socialist countries in the Balkan region, employ archival footage from the communist period, to address and problematize the notion of remembering and suppressing national history through collective memory. I specifically focus on the work of the Albanian artist, Armando Lulaj and his videos Albanian Trilogy: A Series of Devious Stratagems (2011, 2012 and 2015) exhibited at the 56th Venice Biennale. By re-using images and narratives produced during Enver Hoxha’s regime, and still ingrained in Albanian visual memory, these films provide alternative readings of Albanian history from the Cold War to the present day. What is more, some of this archival material is made public for the first time, while the rest has been dormant and purposely forgotten in archival vaults. Lulaj’s playful excursions, create connections between a problematic and suppressed past and the difficult and selective present, by juxtaposing evocative and politically charged visual records and contemporary footage of artist’s commissioned performances.
Film and finance. An attempt at a statistical comparison of the attendance results and ratings of Polish films in the years 2012–2015
Authors: Adamczak Marcin , Orankiewicz Agnieszka
Published: January 2019

The article is an attempt to use essential statistical tools for analysis of market performance of films and its aes- thetical judgements made by film critics and fans. The authors describe differences between evaluations of films by professional and non-professional viewers, correlations between market performance and artistic merit and impact of level of public support for success and quality of movies. The material for analysis are Polish films in cinema distribution between 2012 and 2015.
Kolegium Filmowe 2014–2015: TVP w służbie kinematografii
Authors: Majer Artur
Published: January 2019

The article discusses the functioning of the Film Council during its activity in Telewizja Polska in 2014–2015. In less than two years the Council consisting of over a dozen members from several TVP’s departments recommended almost forty coproductions for feature films, regulated procedures for the endorsement of coproduction agreements and aimed to develop TVP’s influence in the process of film promotion and distribution. According to Polish film law, the Council’s job was to stimulate the development of the Polish cinema.
Market Knowledge Dimensions and Cross-Functional Collaboration: Examining the Different Routes to Product Innovation Performance
Authors: De Luca Luigi M. , Atuahene-Gima Kwaku
Published: January 2019

There is consensus in the marketing literature that market knowledge and cross-functional collaboration are two fundamental resources for successful product innovation. However, few studies examine the dimensions or characteristics of market knowledge and how and why these resources influence product innovation performance. Drawing on contingency theory and the knowledge-based view of the firm, the authors argue that knowledge integration mechanisms may account for the effects of market knowledge dimensions (i.e., breadth, depth, tacitness, and specificity) and cross-functional collaboration on product innovation performance. They find that market knowledge specificity and cross-functional collaboration affect product innovation performance through knowledge integration mechanisms. In contrast, whereas the effect of market knowledge depth is partially mediated, market knowledge breadth has a direct, unmediated effect on product innovation performance. A test of an alternative moderating perspective shows that the effects of market knowledge depth and cross-functional collaboration on product innovation are negatively moderated by knowledge integration mechanisms. By showing the differential effects of market knowledge dimensions on product innovation performance, the authors provide a more refined understanding of the interplay among market knowledge, its integration, and the firm's performance in product innovation. The authors also conclude that by overlooking the role of knowledge integration mechanisms, previous research may have provided an overly optimistic view of the value of cross-functional collaboration in product innovation.
ParSec: Ein innovatives Funksystem für die Fertigungsautomation
Authors: Underberg Lisa , Kraemer Rolf , von Hoyningen-Huene Johannes , Kays Rüdiger
Published: January 2019

Im Kontext von Industrie 4.0 werden verstärkt drahtlose Kommunikationssysteme in industrielle Anwendungen integriert. Die Anforderungen der Fertigungsautomation, welche besonders streng hinsichtlich Zuverlässigkeit und Latenz sind, werden bisher nur teilweise durch spezifische kabellose Systeme wie WirelessHART oder WSAN erfüllt.

Damit Funksysteme auch in kritischen Anwendungen der Fertigungsautomation eingesetzt werden können, verfolgt das ParSec-Projekt den vielversprechenden Parallel Sequence Spread Spectrum (PSSS)-Ansatz. Dieser Artikel stellt das ParSec-System basierend auf PSSS vor. Das Funktionsprinzip des PSSS-Ansatzes wird erläutert und die Vorteile hinsichtlich eines flexiblen Kommunikationsprotokolls werden beschrieben. Die Integration des ParSec-Funksystems in ein bestehendes Industrial Ethernet-System wird diskutiert.
Quality-of-Service monitoring of hybrid industrial communication networks
Authors: Ehrlich Marco , Neumann Arne , Biendarra Alexander , Jasperneite Jürgen
Published: January 2019

Today many hybrid (wired & wireless) industrial communication networks with a huge variety of heterogeneous technologies and protocols are present in the manufacturing and automation domain. The increasing requirements regarding e. g., latency, reliability, or determinism create the need for a holistic network management concept in order to assure a network-wide Quality-of-Service (QoS) resource provisioning and the assurance of the admissioned resources. Consequently, a monitoring of the whole network is required to feed the network management system with the needed information about the underlying network processes. Various technical approaches using different methods of extracting the information from network traffic are available for the purpose of QoS parameter observance and measurement at the moment. Therefore, this paper provides a state of the art research about network management and QoS provisioning respectively QoS assurance concepts. In addition, the passive network monitoring approach using the flow export technique based on the Internet Protocol Flow Information Export (IPFIX) is investigated for a utilisation in the nowadays industry domain based on a conceptual case study with a wireless protocol. As a conclusion, an evaluation is performed in order to clarify the limits and the overall usability of IPFIX for the monitoring of industrial networks in order to support future network management systems.
Benchmarking the reliability of industrial wireless systems in a virtual factory
Authors: Karunakaran Prasanth , Burkhardt Frank , Schulze Darina
Published: January 2019

Reliability of wireless communication is the key to the next stages of the imminent industrial evolution known as Industry 4.0. Removing the bonds of cabling and wires will provide the ability of free movement and the possibility of deployment in previously unreachable locations. To build confidence in the reliability of wireless transmission systems, a method for measuring said reliability is required. This article describes such a method which forms the basis of two interlinked testbeds being developed within the scope of the Celtic Plus project ReICOvAir.
Mapping the Future.
Authors: Lenel Laetitia
Published: January 2019

The recognition of the key importance of economic stability after World War I sparked interest in business forecasting on both sides of the Atlantic. This article explores the creation and the rapid international and domestic dissemination of the Harvard Index of General Business Conditions in the early 1920s, which contemporaries celebrated as the first “scientific” approach to business forecasting. Drawing on multi-site archival research, the paper analyses the extension of the index by an information-exchange-based method in the 1920s and traces its influence on the survey-based forecasting approach employed by American companies in the 1930s. Engaging with the current debate on the temporal order of capitalism, the article argues that business forecasting was not only a means of stabilizing capitalism, but a factor and an indicator of a change in the dynamics of capitalism in the interwar period.
Does Multiculturalism Inhibit Intercultural Dialogue? Evidence from the Antipodes
Authors: Levey Geoffrey Brahm
Published: January 2019

In recent years, an international debate has erupted over whether and how interculturalism differs from multiculturalism as a response to cultural diversity. An influential argument in this debate is that multiculturalism itself militates against intercultural dialogue. This article scrutinises this argument and challenge its applicability in the Australian context. I examine two case studies of fraught intercultural dialogue: the 2006 clash between the Howard government and the Ethnic Communities’ Council of Victoria over the proposed introduction of a citizenship test; and the Abbott government’s proposed reform of the anti-vilification provisions of the Racial Discrimination Act 1975 (Cth) during 2013–14. The cases suggest that far from undermining intercultural dialogue, respecting the terms of Australian multiculturalism would help to make it possible. Moreover, the cases suggest that if pursued genuinely, intercultural dialogue could contribute improved policy outcomes.
From Habits to Rituals: Rituals as Social Habits
Authors: Giovagnoli Raffaela
Published: January 2019

The present contribution aims at investigating the relationship between habits and rituals; they are based on the same processes even though they have different functions depending on the context (personal or social). Our discussion will mostly focus on the nature and function of rituals, as necessary practices in human and other animals’ social lives. After a brief introduction of the notion of “habit” by reference to relevant studies that cross philosophy and neurobiology, we propose an interpretation of rituals as collective activity, which is based on the same mechanisms of habits formation, but it is expressed in a “We-form”, from which it is created and institutionalized
Vibration Simulation of Multilayer Stacking Packages through Symbol-Numerical Method
Authors: Zhong Chen , Wang Lili , Zhao Dongjing , Zhu Li
Published: January 2019

Distribution packages are commonly stacked as unit loads, and vibration is the main hazard that causes product damage in the logistics stage. A simulation method that considers the vibration of multilayer stacking distribution packages is proposed in this study. First, a dynamic model of a single-layer package is investigated to clarify the vibration mechanism. Second, a simulation model is built to clarify the vibration of a single-layer package. Third, a multilayer vibration model is proposed on the basis of the single-layer model, and the calculation method of the simulation parameters is analyzed using a mathematical model. Verification experiments are also performed in a self-designed typical box. Furthermore, a correction method is investigated for the simulation errors. The correcting effect is clarified by comparing the power spectral density between experimental and simulation results. The relationship between the spring constants of a multi- and a single layer and the stacking layer number is also analyzed. Finally, two types of equations are proposed for the multilayer stacking model of distribution packages.
Perceived Conflict and Support Among Women with Bulimia Nervosa Compared to Women with Depression and Healthy Controls: An Experimental Manipulation
Authors: Serier Kelsey N. , Smith Jamie M. , Finstad Erica M. , Laframboise Denise , Erickson Brenda , Moreshead Margaret , Smith Jane Ellen
Published: January 2019

Objective: Women with bulimia nervosa (BN) often present with interpersonal difficulties. It is unknown whether these difficulties primarily are based on distorted social perceptions, and whether they are unique to BN. The current study used a repeated-measures design to compare perceptions of interpersonal interactions for participants with BN, depression (DEP), and healthy controls (HCs). We hypothesized that women with BN would perceive more conflict and less support than HCs. Analyses comparing BN and DEP were exploratory.

Method: Participants with BN (n = 27) or DEP (n = 26) and HCs (n = 27) rated perceived conflict and support for 24 vignettes depicting social interactions that varied in levels of these two constructs. Participants also completed relationship quality/satisfaction questionnaires.

Results: Multilevel model analyses revealed that the BN group perceived greater conflict relative to HCs. There also were significant interactions, with BN participants more greatly impacted by high support. There were no differences between DEP and BN groups.

Discussion: Overall, BN participants perceived more conflict than HCs, but differences were attenuated when level of social support was high. Helping women with BN tolerate discomfort associated with any amount of perceived conflict and/or low support may be an important treatment target.
Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development
Authors: Xu Xiaxia , Chini Mattia , Bitzenhofer Sebastian H. , Hanganu-Opatz Ileana L.
Published: January 2019

Compromised brain development has been hypothesized to account for mental illness. This concept was underpinned by the function of the molecule disrupted-in-schizophrenia 1 (DISC1), which represents an intracellular hub of developmental processes and has been related to cognitive dysfunction in psychiatric disorders. Mice with whole-brain DISC1 knock-down show impaired prefrontal–hippocampal function and cognitive abilities throughout development and at adulthood, especially when combined with early environmental stressors, such as maternal immune activation (MIA). However, the contribution of abnormal DISC1-driven maturation of either prefrontal cortex (PFC) or hippocampus (HP) to these deficits is still unknown. Here, we usein uteroelectroporation to restrict the DISC1 knock-down to prefrontal layer II/III pyramidal neurons during perinatal development and expose these mice to MIA as an environmental stressor (dual-hit GPFCE mice, both sexes). Combiningin vivoelectrophysiology and neuroanatomy with behavioral testing, we show that GPFCE mice at neonatal age have abnormal patterns of oscillatory activity and firing in PFC, but not HP. Abnormal firing rates in PFC of GPFCE mice relate to sparser dendritic arborization and lower spine density. Moreover, the long-range coupling within prefrontal–hippocampal networks is decreased at this age. The transient prefrontal DISC1 knock-down was sufficient to permanently perturb the prefrontal–hippocampal communication and caused poorer recognition memory performance at pre-juvenile age. Thus, developmental dysfunction of prefrontal circuitry causes long-lasting disturbances related to mental illness.

SIGNIFICANCE STATEMENTHypofrontality is considered a main cause of cognitive deficits in mental disorders, yet the underlying mechanisms are still largely unknown. During development, long before the emergence of disease symptoms, the functional coupling within the prefrontal–hippocampal network, which is the core brain circuit involved in cognitive processing, is reduced. To assess to which extent impaired prefrontal development contributes to the early dysfunction, immune-challenged mice with transient DISC1 knock-down confined to PFC were investigated in their prefrontal–hippocampal communication throughout development byin vivoelectrophysiology and behavioral testing. We show that perturbing developmental processes of prefrontal layer II/III pyramidal neurons is sufficient to diminish prefrontal–hippocampal coupling and decrease the cognitive performance throughout development.
Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking
Authors: Pardo-Garcia Thibaut R. , Garcia-Keller Constanza , Penaloza Tiffany , Richie Christopher T. , Pickel James , Hope Bruce T. , Harvey Brandon K. , Kalivas Peter W. , Heinsbroek Jasper A.
Published: January 2019

Outputs from the nucleus accumbens (NAc) include projections to the ventral pallidum and the ventral tegmental area and subtantia nigra in the ventral mesencephalon. The medium spiny neurons (MSN) that give rise to these pathways are GABAergic and consist of two populations of equal number that are segregated by differentially expressed proteins, including D1- and D2-dopamine receptors. Afferents to the ventral pallidum arise from both D1- and D2-MSNs, whereas the ventral mesencephalon is selectively innervated by D1-MSN. To determine the extent of collateralization of D1-MSN to these axon terminal fields we used retrograde labeling in transgenic mice expressing tdTomato selectively in D1-MSN, and found that a large majority of D1-MSN in either the shell or core subcompartments of the accumbens collateralized to both output structures. Approximately 70% of D1-MSNs projecting to the ventral pallidum collateralized to the ventral mesencephalon, whereas >90% of mesencephalic D1-MSN afferents collateralized to the ventral pallidum. In contrast, <10% of dorsal striatal D1-MSNs collateralized to both the globus pallidus and ventral mesencephalon. D1-MSN activation is required for conditioned cues to induce cocaine seeking. To determine which D1-MSN projection mediates cued cocaine seeking, we selectively transfected D1-MSNs in transgenic rats with an inhibitory Gi-coupled DREADD. Activation of the transfected Gi-DREADD with clozapine-N-oxide administered into the ventral pallidum, but not into the ventral mesencephalon, blocked cue-induced cocaine seeking. These data show that, although accumbens D1-MSNs largely collateralize to both the ventral pallidum and ventral mesencephalon, only D1-MSN innervation of the ventral pallidum is necessary for cue-induced cocaine seeking.

SIGNIFICANCE STATEMENTActivity in D1 dopamine receptor-expressing neurons in the NAc is required for rodents to respond to cocaine-conditioned cues and relapse to drug seeking behaviors. The D1-expressing neurons project to both the ventral pallidum and ventral mesencephalon, and we found that a majority of the neurons that innervate the ventral pallidum also collateralize to the ventral mesencephalon. However, despite innervating both structures, only D1 innervation of the ventral pallidum mediates cue-induced cocaine seeking.
Divided Attention Selectively Impairs Value-Directed Encoding
Authors: Elliott Blake L. , Brewer Gene A.
Published: January 2019

In the present study, we examined the effect of value-directed encoding on recognition memory and how various divided attention tasks at encoding alter value-directed remembering. In the first experiment, participants encoded words that were assigned either high or low point values in multiple study-test phases. The points corresponded to the value the participants could earn by successfully recognizing the words in an upcoming recognition memory task. Importantly, participants were instructed that their goal was to maximize their score in this memory task. The second experiment was modified such that while studying the words participants simultaneously completed a divided attention task (either articulatory suppression or random number generation). The third experiment used a non-verbal tone detection divided attention task (easy or difficult versions). Subjective states of recollection (i.e., “Remember”) and familiarity (i.e., “Know”) were assessed at retrieval in all experiments. In Experiment 1, high value words were recognized more effectively than low value words, and this difference was primarily driven by increases in “Remember” responses with no difference in “Know” responses. In Experiment 2, the pattern of subjective judgment results from the articulatory suppression condition replicated Experiment 1. However, in the random number generation condition, the effect of value on recognition memory was lost. This same pattern of results was found in Experiment 3 which implemented a different variant of the divided attention task. Overall, these data suggest that executive processes are used when encoding valuable information and that value-directed improvements to memory are not merely the result of differential rehearsal.
Forever Her Chinatown
Authors: Seid Danielle
Published: January 2019

This essay adopts and adapts memory work, as developed by Annette Kuhn, as a method to search for the author's grandmother in Chinese American feminist film history. Foregrounding a trans-feminist perspective that moves across and between nations and film cultures, it introduces readers to a relatively unknown “orphan” documentary film, Forever Chinatown (1960). For the author and her family, the film carries with it a history of trauma that shapes what is remembered about it. Drawing on work in feminist film studies, particularly the notion of an archive of feelings, the essay blends life writing, theory, and visual-textual analysis to both allow the author to write her way into the film and trace her grandmother's presence in and labor on the film.
CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy
Authors: Sun Jia , Zhu Haiping , Wang Xiaorong , Gao Qiuqi , Li Zhuoying , Huang Huiya
Published: January 2019

The molecular signaling mechanisms of Coenzyme Q10 (CoQ10) in diabetic nephropathy (DN) remain poorly understood. We verified that mitochondrial abnormalities, like defective mitophagy, the generation of mitochondrial reactive oxygen species (mtROS) and the reduction of mitochondrial membrane potential, occurred in the glomerulus of db/db mice, accompanied by reduced PINK and parkin expression and increased apoptosis. These changes were partially reversed following oral administration of CoQ10. In inner fenestrated murine glomerular endothelial cells (mGECs), high glucose (HG) also resulted in deficient mitophagy, mitochondrial dysfunction and apoptosis, which were reversed by CoQ10. Mitophagy suppression mediated by Mdivi-1 or siPINK abrogated the renoprotective effects exerted by CoQ10, suggesting a beneficial role for CoQ10-restored mitophagy in DN. Mechanistically, CoQ10 restored the expression, activity and nuclear translocation of Nrf2 in HG-cultured mGECs. In addition, the reduced PINK and parkin expression observed in HG-cultured mGECs were partially elevated by CoQ10. CoQ10-mediated renoprotective effects were abrogated by the Nrf2 inhibitor ML385. When ML385 abolished mitophagy and the renoprotective effects exerted by CoQ10, mGECs could be rescued by treatment with mitoTEMPO, which is a mtROS-targeted antioxidant. These results suggest that CoQ10, as an effective antioxidant in mitochondria, exerts beneficial effects in DN via mitophagy by restoring Nrf2/ARE signaling. In summary, CoQ10-mediated mitophagy activation positively regulates DN through a mechanism involving mtROS, which influences the activation of the Nrf2/ARE pathway.
High Level of Conservation of Mitochondrial RNA Editing Sites Among Four Populus Species
Authors: Brenner Wolfram Georg , Mader Malte , Müller Niels Andreas , Hoenicka Hans , Schroeder Hilke , Zorn Ingo , Fladung Matthias , Kersten Birgit
Published: January 2019

RNA editing occurs in the endosymbiont organelles of higher plants as C-to-U conversions of defined nucleotides. The availability of large quantities of RNA sequencing data makes it possible to identify RNA editing sites and to quantify their editing extent. We have investigated RNA editing in 34 protein-coding mitochondrial transcripts of four Populus species, a genus noteworthy for its remarkably small number of RNA editing sites compared to other angiosperms. 27 of these transcripts were subject to RNA editing in at least one species. In total, 355 RNA editing sites were identified with high confidence, their editing extents ranging from 10 to 100%. The most heavily edited transcripts were ccmB with the highest density of RNA editing sites (53.7 sites / kb) and ccmFn with the highest number of sites (39 sites). Most of the editing events are at position 1 or 2 of the codons, usually altering the encoded amino acid, and are highly conserved among the species, also with regard to their editing extent. However, one SNP was found in the newly sequenced and annotated mitochondrial genome of P. alba resulting in the loss of an RNA editing site compared to P. tremula and P. davidiana. This SNP causes a C-to-T transition and an amino acid exchange from Ser to Phe, highlighting the widely discussed role of RNA editing in compensating mutations.
Coexistência de diabetes não influencia a hipotensão pós-exercício em indivíduos com hipertensão
Authors: Heubel Alessandro Domingues , Gonçalves Ingrid Rita , Iwamoto Helen Cristina Tiemi , Gimenes Camila , Pessoa Bruna Varanda , Martinelli Bruno , Arca Eduardo Aguilar , Barrile Silvia Regina
Published: January 2019

Introdução: A hipertensão arterial sistêmica (HAS) e a diabetes mellitus tipo 2 (DM2) são patologias que frequentemente coexistem. A hipotensão pós-exercício (HPE) é bem documentada em indivíduos com HAS, porém não é certo se ocorre na coexistência de DM2.Objetivos: Investigar se a coexistência de DM2 influencia no efeito hipotensor pós-exercício aeróbio em indivíduos com HAS.Materiais e Métodos: Foram incluídos 33 indivíduos, distribuídos em dois grupos: Grupo HAS (n=17) e Grupo HAS+DM2 (n=16). Ambos submetidos às sessões exercício e controle. O protocolo de exercício consistiu em 10 minutos de aquecimento, 40 minutos de exercício aeróbio moderado em cicloergômetro e 10 minutos de alongamentos. No pré e pós-exercício (sete horas subsequentes), foram avaliados quanto à pressão arterial (PA), frequência cardíaca (FC) e duplo produto (DP). A análise estatística foi realizada pelo teste t independente e ANOVA de medidas repetidas, seguido do post hoc de Tukey.Resultados: Ambos os grupos apresentaram redução (p<0,05) dos parâmetros hemodinâmicos após o exercício, com duração de até quatro horas. No Grupo HAS, observamos diminuição dos valores de PA sistólica (até -11 mmHg), PA diastólica (até -7 mmHg), FC (até -5 bpm) e DP (até -1240 bpm.mmHg). No Grupo HAS+DM2, verificamos redução da PA sistólica (até -9 mmHg), FC (até -5 bpm) e DP (até -1206 bpm.mmHg).Conclusão: O exercício aeróbio moderado promoveu redução de parâmetros hemodinâmicos em indivíduos com HAS isolada e na coexistência de DM2. No entanto, verificamos que a magnitude da HPE não foi alterada na coexistência de DM2.
A responsabilização civil dos genitores por abandono afetivo de filhos homossexuais
Authors: Boff Rogers Alexander , Barbosa Valéria Koch
Published: January 2019

Com base em uma pesquisa amparada na legislação, na doutrina e na jurisprudência, este estudo aborda não apenas as discussões acerca da possibilidade de responsabilização civil dos pais por abandono afetivo, como trata da punição para aqueles que deixam de cumprir os seus deveres motivados pelo preconceito quanto à orientação sexual de seus filhos. Conforme a Constituição Federal do Brasil, compete aos genitores proporcionar todos os cuidados necessários ao desenvolvimento de seus filhos, o que inclui não apenas a subsistência, mas também amparo, amor e afeto. Assim, os resultados deste estudo apontam que é dever dos pais prestar ampla proteção à sua prole, independentemente de orientação sexual, podendo ser responsabilizados civilmente de forma mais gravosa se o abandono afetivo de seus filhos for advindo de preconceito, uma vez que tal conduta afronta um dos princípios basilares da Carta Constitucional pátria.
A reparação civil no abandono afetivo
Authors: Bagetti Kedi Leticia
Published: January 2019

A concepção atual de família não respeita um modelo definido. A família contemporânea tem como pilar o afeto, pois é a partir daí que se formam seres humanos. As obrigações dos genitores pelo cuidado dos filhos e o direito/dever de convivência familiar decorrem do princípio da afetividade. A privação do filho, na condição de ser em desenvolvimento, da convivência com qualquer dos genitores pode ser capaz de gerar danos que nem o tempo é capaz de apagar, e o próprio direito garante que aquele que sofre um dano o por ato comissivo ou omisso de outrem, tem direito à reparação. É nesse contexto que surge a ideia da responsabilidade civil pelo abandono afetivo, matéria polêmica e que já vem sendo enfrentada pelos tribunais do país. Partindo do princípio da afetividade e pressupostos da responsabilidade civil, este artigo busca analisar a questão sob o aspecto teórico e prático, abordando os posicionamentos jurisprudenciais que envolvem o tema, que é de suma importância, objetivando traçar um caminho para que a situação não passe despercebida pelo Poder Judiciário e tampouco seja banalizada pelos operadores do direito.
Da possibilidade de apadrinhamento de crianças e adolescentes no Brasil
Authors: Paiano Daniela Braga , Rocha Maurem Silva
Published: January 2019

O Estatuto da criança e do adolescente prevê o direito a convivência familiar e comunitária em um ambiente que garanta seu desenvolvimento integral. A família natural é a prioridade, devendo ser empreendidos esforços para sua manutenção. Não sendo isto possível, a família extensa é o caminho menos agressivo. Não sendo possível, o acolhimento e posteriormente a colocação em família substituta são medidas excepcionais. Porém, não estando no perfil pretendido pelos habilitados à adoção, estão estas crianças/adolescentes fadadas ao acolhimento institucional. O apadrinhamento afetivo surge como uma possibilidade de convivência e afeto para estas crianças/adolescentes que tenham poucas chances de adoção. No Brasil, existem poucos exemplos de Tribunais que normatizaram o tema. Importante trazer a legislação de Portugal, que regulamentou o instituto. Por fim, a proposta de uma legislação brasileira que regulamentasse a questão, trazendo regras claras e uniformes proporcionaria segurança jurídica àqueles que aderem ao programa e possibilidades aos que aguardam uma relação de afeto e cuidado.
TATA KELOLA PEMUKIMAN NELAYAN DI WILAYAH PERKOTAAN PESISIR UTARA JAKARTA
Authors: Maharani Hertria , Nurlaili Nurlaili
Published: January 2019

Pemukiman nelayan di kawasan perkotaan belum banyak diperhatikan oleh pemerintah. Seharusnya sebagai bagian dari perencanaan kota, pemukiman nelayan mempunyaI urgensi yang sama untuk diatur sehingga dapat dikelola dengan baik. Makalah ini mempunyai tiga tujuan utama, yaitu: 1) Mengidentifikasi kondisi eksisting kawasan pemukiman nelayan; 2) Mengidentifikasi hambatan perencanaan pemukiman nelayan di perkotaan; dan 3) menganalisis peran perencanaan kota pada tatakelola pemukiman nelayan. Observasi hanya dilakukan di pantai utara Teluk Jakarta (Kamal Muara) terkait kondisi eksisting dan hambatan perencanaan pemukiman nelayan. Data primer diperoleh dari hasil wawancara informan kunci dengan menggunakan bantuan topik data. Hasil penelitian menunjukkan bahwa kondisi pemukiman nelayan masih jauh dari kondisi ideal, yang mulai dari sanitasi, desain pemukiman, drainase dan sebagainya. Sedangkan terdapat 3 stakeholder yang  bertanggungjawab atas kesulitan pengaturan pemukiman nelayan yaitu masyarakat nelayan, pemerintah dan instansi swasta termasuk  pengembang dan perbankan. Ketiga elemen stakeholder tersebut harus bersamasama melakukan upaya untuk perbaikan tata kelola pemukiman nelayan dengan tanpa melupakan pemahaman bahwa nelayan tidak dapat dipisahkan dari laut dan tepi pantai sebagai tempat  bekerja, komunitas dan budaya.Title: Fisherman Settlement Management in Urban Region of Northern-Coast of Jakarta Fisherman settlements in urban areas have received less attention by the government. As a part of urban planning, fisherman settlements should have the same urgency to be well governed. This paper has three main objectives: 1) to identify existing conditions of fishermen residential areas; 2) to identify barriers on planning of fisherman settlements in urban area; and 3) to analyze the role of urban planning on fisherman settlements governance. Observation toward existing conditions and the barriers on fisherman settlements planning were only completed in Kamal Muara, the northern coast of Jakarta Bay. Primary data were obtained from key informant interviews using data topic tool. The results show that the conditions of the fisherman settlement is still under ideal level, including its sanitation, settlement design, drainage, etc. There are 3 stakeholders who are responsible for the difficulties in regulating fisherman settlements, they are fishing communities, government and private institutions including developers and commercial banks. These three elements must jointly improve the governance of fisherman settlements under the same perception that fishermen cannot be  separated from the sea and coast area as a work place, community and culture.
KAJIAN INDEKS VARIABILITAS TINGGI GELOMBANG SIGNIFIKAN DI INDONESIA
Authors: Habibie Muhammad Najib , Fitria Welly
Published: January 2019

Informasi karakteristik gelombang merupakan hal yang sangat penting dalam berbagai bidang seperti pelayaran, industri, pariwisata dan keamanan struktur lepas pantai. Penelitian mengenai karakteristik gelombang telah dilakukan oleh banyak peneliti baik dalam skala global maupun regional. Metode yang digunakan umumnya adalah perata-rataan yang menghilangkan variasi selama data tersebut diproduksi. Variasi data tersebut ada kalanya dibutuhkan untuk melihat tingkat kestabilan data selama kurun waktu tertentu. Tujuan penelitian ini adalah untuk mengetahui distribusi spasial dan temporal tinggi gelombang signifikan di wilayah Indonesia serta mengetahui tingkat kestabilannya. Pada penelitian ini dilakukan analisa kestabilan tinggi gelombang melalui perhitungan koefisien variasi, indeks variabilitas bulanan dan indeks variabilitas musiman. Data yang digunakan adalah luaran model WAVEWATCH-III pada jangka waktu tahun 1991-2015 dengan time step 3 jam. Hasil penelitian menunjukkan bahwa gelombang signifikan memiliki pola variabilitas berdasarkan siklus monsunal. Gelombang signifikan di Indonesia mencapai puncaknya bersamaan dengan aktifnya monsun Asia dan Australia di bulan DJF dan JJA. Tingkat kestabilan yang direpresentasikan oleh koefisien variasi mencapai nilai terendah juga pada musim ini. Hal ini berarti pada saat monsun aktif, gelombang signifikan cenderung stabil dibandingkan dengan musim peralihan. Distribusi spasial menunjukkan bahwa daerah laut lepas lebih tinggi gelombangnya dibanding di laut tertutup. Koefisien variasi dan indeks variabilitas musiman dan bulanan menunjukkan daerah laut lepas memiliki tingkat kestabilan yang lebih tinggi. Daerah yang paling stabil yaitu S. Hindia diikuti S. Pasifik dan Laut Cina Selatan. Sedangkan perairan yang tidak stabil meliputi Teluk Tomini, Laut Flores dan Selat Malaka.
Spirituality and psycho-organic regulation
Authors: Cvetek Robert , Gostečnik Christian , Pate Tanja , Simonič Barbara , Valenta Tanja , Repič Slavič Tanja
Published: January 2019

Traumatic experiences are very important for the psycho-organic regulation of an individual. These experiences can very profoundly mark an individual, especially if they happened in childhood. They can be very disruptive and they scream for healing. In this process of healing spirituality plays a crucial role. Religiousness and sacramental life can be an essential regulatory system in the establishment of a functional psycho–organic response and spiritual life.
Luigi Giussani and Catholic Historiography
Authors: Klumpenhouwer Samuel
Published: January 2019

This essay explores the difficulties of conducting historiographical research from a Catholic view point. It through the life and writings of Luigi Giussani, founder of the movement Communion and Liberation. Three main approaches to history will be explored: the rationalist approach, the Protestant approach, and finally the Orthodox-Catholic approach. The essay argues that only the third approach is sufficient to examine the historical claims about Jesus.