bluuebunny/crossref_metadata_2025 huggingface dataset:
​Effects of Time Specific Supplementation of Insulin Like Growth Factor-I (IGF-I) on in vitro Development of Sheep Preantral Follicles
Authors: Pathipati Deepa , Chigurupati Srinivasa Prasad , Kumar A.V.N. Siva , Kumari B. Punya , Kumar R.V. Suresh
Published: July 2021

Background: In in vitro culture systems IGF-I was known to promote follicular maturation, granulosa cell proliferation and increase overall cellular function. The expression patterns of developmentally important markers for IGF-I are expressed differentially during the transition of preantral follicles to the ovulatory stage. Therefore, we aimed to investigate the influence of time specific addition of Insulin like growth factor-I (IGF-I) on in vitro development of sheep preantral follicles (PFs’). Methods: Mechanically isolated sheep preantral follicles were cultured for six days either in TCM 199B or standard medium supplemented with IGF-I at different points during the culture period and were subsequently subjected to in vitro maturation (IVM) for additional 24hrs to evaluate different follicular development parameters. Conclusion: Based on the results, it is concluded that: 1) IGF-I supplementation was needed during early rather than later stages of culture period, therefore, role of IGF-I in time/stage specific manner in cultured preantral follicles is confirmed. 2) Supplementation of TCM 199B with IGF-I simultaneously for the first two days followed by TCM 199B alone without any growth factor (s) in later days (Treatment 1) supported better development of PFs’ in vitro.
Laporan Kasus: Gestational Diabetes Mellitus pada Anjing Pug Betina Pascamelahirkan yang Ketiga
Authors: Swandewi Ni Kadek Meita , Soma I Gede , Suartha I Nyoman
Published: July 2021

Seekor anjing betina ras Pug berumur empat tahun dengan bobot badan 4,5 kg menunjukkan tanda klinis berupa poliuria, polidipsia, polipagia, dan penurunan bobot badan yang sangat signifikan dalam waktu tiga bulan setelah melahirkan. Pemeriksaan biokimia darah menunjukkan adanya peningkatan kadar glukosa dalam darah hingga 669 mg/dL dan pengujian dipstick urin menunjukkan adanya glukosa di dalam urin dengan hasil ? 2000 mg/dL. Anjing didiagnosis mengalami diabetes mellitus. Hewan kasus diberikan terapi berupa penggantian pakan menggunakan pakan khusus diabetik (Royal Canin Diabetic food ®) dan injeksi insulin glargine dengan dosis 0, 44 IU/kg BB dua kali sehari sebelum makan. Setelah dua minggu terapi, anjing kasus menunjukkan perkembangan yang baik yang ditunjukkan dengan menurunnya kadar glukosa darah menjadi 163 mg/dL dan menurunnya gejala klinis berupa poliuria, polidipsia, dan polipagia, walaupun bobot badan belum berhasil dipulihkan sepenuhnya.
Laporan Kasus: Keberhasilan Memulihkan Demodekosis General pada Anjing Pomeranian Betina dalam Tempo Satu Bulan
Authors: Hasanah Putri Nur , Soma I Gede , Erawan I Gusti Made Krisna
Published: July 2021

Anjing berumur ±3 tahun, ras Pomeranian berjenis kelamin betina dengan gejala klinis eritema pada bagian wajah, ekor, dan bagian kaki, multifokal alopesia, crusta, hiperkeratosis pada bagian wajah dan ekor, dan hiperpigmentasi pada seluruh bagian kulit sehingga kulit terlihat menghitam. Anjing tidak terlalu sering menggaruk dan tercium bau tengik. Pada pemeriksaan deep skin scraping, trichogram dan skin tape ditemukan tungau Demodex sp. Isolasi dan identifikasi jamur dilakukan dengan hasil negatif. Hasil pemeriksaan hematologi rutin menunjukkan anjing kasus mengalami anemia mikrositik hiperkromik dan neutrofilia. Berdasarkan anamnesis, pemeriksaan fisik, dan penunjang, anjing kasus didiagnosis menderita demodekosis general. Pengobatan dilakukan dengan pemberian amitraz, ivermectin, dipenhydramin HCl, fish oil, dan Vi-sorbits selama empat minggu. Pada minggu keempat setelah pengobatan menunjukkan adanya perbaikan dengan sudah tidak ditemukannya lesi pada kulit dan rambut tumbuh dengan baik sehingga rambut tampak sehat dan bertambah lebat.
Laporan Kasus: Cystolithiasis Disertai Hematuria pada Kucing Kampung Jantan
Authors: Nirhayu Nirhayu , Sibang I Nengah Anom Adi Nugraha , Erawan I Gusti Made Krisna , Widyastuti Sri Kayati
Published: July 2021

Cystolithiasis merupakan keadaan ditemukan urolith/kalkuli di dalam vesika urinaria. Masalah tersebut umum dan sering terjadi pada kucing. Seekor kucing lokal jantan berumur satu tahun dengan bobot badan 4,6 kg diperiksa di Rumah Sakit Hewan Pendidikan, Fakultas Kedokteran Hewan, Universitas Udayana dengan keluhan disuria dan hematuria. Pemeriksaan ultrasonografi ditemukan adanya bentukan pasir pada vesika urinaria. Pemeriksaan sedimentasi urin menunjukkan adanya kristal struvit. Kucing didiagnosis menderita cystolithiasis akibat struvit. Hewan kasus ditangani dengan cara pemberian kombinasi cefotaxim (20 mg/kg BB, q12h, selama tujuh hari), dexametasone (0,1 mg/kg BB, q12h, selama tujuh hari), dan kapsul kejibeling dengan kandungan sericocalycis folium 100 mg, sonchi folium 125 mg, orthosiphonis folium 125 mg (satu kapsul, q24h, selama tujuh hari). Setelah pengobatan selama tujuh hari, urinasi menjadi lancar, tidak adanya indikasi rasa sakit saat urinasi dan tidak adanya hematuria.
О ПРОБЛЕМСКИМ И ДИСКУРСНИМ АСПЕКТИМА ДНЕВНИКА ПЕНЕ МИОДРАГА ПАВЛОВИЋА
Authors: Dеspić Đоrđе М.
Published: July 2021

Текст тежи да истакне проблемске и дискурсне специфичности Дневника пене Миодрага Павловића. У контексту рецепције Павловићевог есејистичког опуса ова есејистичка књига није привукла пуно пажње, иако садржи важна и луцидна промишљања битних књижевних феномена који одликују добар део његовог укупног стваралаштва, попут песничке имагинације, мита, модерности, еротског, антислике. Такође, рад ће настојати да аналитички укаже на Дневник пене као на дискурсно слојевиту књигу, коју карактеришу  жанровска хетерогеност и фрагментарност у поступку.
OSNOVNE CRTE PREDFILOZOFSKOG ISKUSTVA TEORIJE
Authors: Tatalović Nikola
Published: July 2021

Ovaj rad posvećen je ispitivanju osnovnih momenata predfilozofskog iskustva teorije. Rad pokazuje da je izvorni smisao teorije nerazdvojan je od njegovog religiozno-političkog konteksta. Unutar datog konteksta izvorno iskustvo teorije se pokazuje u svojoj trostrukoj strukturi: napuštanje poznatog, putovanje i posmatranje božanskog, te povratak u poznato. Analiza pokazuje da iskustvo teorije kao specifično putovanje u strano podrazumeva određeno držanje posmatrača, a da samo posmatranje zapravo znači boravljenje unutar regije pojavljivanja božanskog koje preobražava posmatrača.
EVENT-CANCELLING SEMANTICS OF THE ENGLISH ASPECTUALIZER START AND ITS SERBIAN EQUIVALENT KRENUTI
Authors: Milivojević Nataša
Published: July 2021

The paper revisits the issue of semantic equivalency of two aspectual verbs, start and krenuti, which is proposed by xxx (2021a, 2021b). The present analysis focuses on the causative and dynamic semantic features of start and krenuti, with the aim of a contrastive analysis of the aspectual constructions headed by these two verbs. It is shown that both start and krenuti, provided that the necessary linguistic conditions are met, have the ability to “cancel” the event initiated via constructional phase modification. The conditions for such event-cancelling result from the lexical semantics of start and krenuti, as well as from the semantic co-composition on the level of the aspectual construction as a whole. The theoretical frame of the analysis is the presupposition and consequence account by A. Freed (1979). The contrastive analysis and presented theoretical conclusions are backed by a parallel corpus of 200 English and Serbian sentences compiled from the Corpus of Global Web-Based English (GlowBE 2013) and the Corpus of Contemporary Serbian Language (SrpKor 2013).

Key words: aspectualizers, aspectual constructions, aspectual event, temporal structure, presupposition and consequence, event-cancelling
MANAJEMEN STRATEGIK PEMASARAN PENDIDIKAN BERBASIS MEDIA SOSIAL DI MADRASAH ALIYAH YAYASAN PONDOK PESANTREN BABAKAN JAMANIS PARIGI PANGANDARAN
Authors: Nurmalasari Neneng , Masitoh Imas
Published: July 2021

This study describes an overview of the use of social media as a management marketing strategy at Madrasah Aliyah Yayasan Pondok Pesantren Babakan Jamanis. The benefits of social media as a marketing tool in the world of education in the era of the 4.0 industrial revolution are the right choice because it is increasingly accessible to various groups. This research is qualitative research with data collection methods through observation, in-depth interviews, and documentation. The results show that the social media-based educational marketing strategy management is used, namely: Facebook, Instagram, and Youtube by first identifying in the community which then becomes an educational marketing strategy by highlighting the achievements of these institutions. The management of private education, supported by stakeholders and adequate facilities has provided a distinctive feature and strength in the management of educational marketing strategies at Madrasah Aliyah Yayasan Pondok Pesantren Babakan Jamanis.
MANAGEMENT OF EARLY CHILD’S CHARACTER DEVELOPMENT THROUGH HABITUATION AND EXEMPLARY IN KINDERGARTEN
Authors: Utami Sofiana , Wafi Abdul
Published: July 2021

The four problems that become the main study in this study. First, how to plan early child’s character development through habituation and exemplary in the Kindergarten of Al-Quran Matsaratul Huda Panempan Pamekasan. Second, how to organize the development of early child’s character through habituation and exemplary in the kindergarten of Al-Quran Matsaratul Huda Panempan Pamekasan. Third, how the implementation of early child’s character development through habituation and exemplary in the kindergarten of Al-Quran Matsaratul Huda Panempan Pamekasan. Fourth, how to evaluate the character development of the early child through habituation and examplary in the kindergarten of Al-Quran Matsaratul Huda Panempan Pamekasan. It is a qualitative descriptive study where the data collected through field observation, interviews, and documentation. The results showed that developing an early child’s character should be well managed. Instilling good habituation for the children and becoming an excellent example of the teachers proved successful in early child’s character development.
PERAN KOMITE MADRASAH DALAM MEMBANTU MENGEMBANGKAN SARANA PRASARANA DI MADRASAH ALIYAH NEGERI 2 PAMEKASAN
Authors: Mutohharoh Laily
Published: July 2021

In educational units such as madrasas, the existence of madrasa committees is very important. Whether its role has a big impact or not, this independent institution plays a very important role in improving the quality of services by providing consideration, direction, and support for personnel, facilities, and infrastructure as well as supervision at the level of the education unit. This study aims to describe the role of the madrasah committee in helping to develop infrastructure at MAN 2 Pamekasan, with sub-focuses including (1) the concept of infrastructure development, (2) the implementation of infrastructure development, (3) the implications of infrastructure development, carried out at Madrasah Aliyah Negeri 2 Pamekasan. This research uses a qualitative approach with the type of case study. The results of this study indicate that: 1) the concept of infrastructure development is carried out by setting goals in advance and making a madrasa committee work program, 2) the implementation of infrastructure development is carried out with the madrasa committee acting as a giver of consideration, as a supporter, as a controller and as a mediator, 3) The perceived implication of the development of infrastructure facilities is the increasing number of infrastructure facilities owned by madrasas which are now by the standardization of infrastructure facilities that have been determined.
MANAJEMEN SISTEM INFORMASI DALAM KEGIATAN PENERIMAAN SANTRI BARU DI PONDOK PESANTREN PUTERI KHADIJAH PAMEKASAN
Authors: Herliana Ika , Qosim Mubah Hilmi , Ahmadi Ahmadi
Published: July 2021

This study aims to determine the management of information systems, supporting and inhibiting factors in the acceptance of new students at the Puteri Khadijah Islamic Boarding School Pamekasan. This study uses a qualitative approach with a descriptive type of research. Data obtained from observation, interviews, and documentation. The results showed that first, in managing the information system for admitting new students at the Islamic boarding school, they planned by forming a committee, determining the opening and closing dates, the conditions that must be met, providing website-based forms, and file deposits and evaluating each process carried out. This has been done directly or in writing, after the entire program has been carried out with the evaluation, of course, to find out what is still lacking from the performance to the new student admissions committee then corrected in the future. Second, the supporting factors are the guidance from the caregivers, the direction from the coaches, and also the cooperation of the New Santri Admission committee, completeness of facilities, and infrastructure. The inhibiting factor is the lack of communication between fellow New Santri Admission committees
Local Epistemological Perceptions that Underlie EFL Literature and Teaching Practices in Colombia
Authors: Bonilla-Mora Martha Isabel , López-Urbina Johanna Patricia
Published: July 2021

This study aims to understand the local and updated epistemological perceptions of the teaching and learning of English as a foreign language (EFL) in Colombia from the voices of English language university teachers. This qualitative research emerges as part of a hermeneutical perspective which allowed the authors to analyze experiences, perceptions, and understandings of teachers in the foreign language-teaching field. Data collection instruments included a literature review using framework matrices and semi-structured interviews. After data analysis, three categories emerged: Pertinence and Relevance of Teaching and Learning of EFL, Teaching and Learning of EFL, and The State of Bilingualism. The study concludes with the recommendation of promoting the teaching and learning of foreign languages based on contextualized necessities of Colombia. We draw attention to the cultural and linguistic diversity in our country. In addition, we raise awareness among preservice teachers towards an epistemological reconstruction that involves the ecology of knowledge, engaging them in critical knowledge and practices from outside the Eurocentric vision.
Dyslexic Individuals’ Narratives on their Process of Becoming English Language Teachers
Authors: Cuervo-Rodríguez Karen Andrea , Castañeda-Trujillo Jairo Enrique
Published: July 2021

This paper reports the findings of a narrative study with two pre-service English language teachers (PELTs) who have dyslexia. The main objective of the study was to understand how this condition of having dyslexia was present in becoming an English language teacher. The two PELTs participated in a life history interview as part of the data collection. By considering the main objective of the study, the researchers used the information collected to write the narratives and subsequently proceeded to interpret and analyze them. The findings show that dyslexia is as serious as any other disability, and it does generate rejection and lack of understanding on the part of teachers and other PELTs. Furthermore, negative feelings linked to the learning or teaching process are generated in PELTs with dyslexia, which leads them to hide their condition to avoid discrimination most of the time. However, findings also show that once negative feelings were overcome, PELTs turn their problem into an advantage, discovering themselves as more empathetic to those with special needs and making them more resourceful teachers. We conclude that although PELTs can turn their weaknesses into strengths, the role of teacher educators is also fundamental in the processes of identity construction; teacher educators might provide spaces and strategies to minimize the conditions that affect the performance of PELTs, both as language students and as language teachers.
Regenerative endodontics model in immature infected rat molars using two step protocol
Authors: Sierra Liliana , Castrillo Ángeles , Ritacco Elizabeth , Miño Cornell Haydeé , Canzobre Mariela C
Published: July 2021

Aim: to develop a model for regenerative endodontics using newly-weaned Wistar rats immature molars with pulp necrosis to histologically describe the evolution of apical tissues following treatment with a bi-antibiotic paste, induced bloodclot formation and MTA. Methods: Ten 25-day-old female Wistar rats were divided into an initial control group (Ci) and two experimental groups in which pulp necrosis was experimentally induced on the left mandibular first molar by exposing the pulp chamber and leaving it open to the oral environment. One of the experimental groups was left untreated (E1) while the other was submitted to a protocol of regenerative endodontics 10 days thereafter (E2). Fifteen days after placement of a bi-antibiotic paste, bleeding was induced into the root canal space and MTA was placed upon. Animals were euthanized 30 days later. Right mandibular first molars served as an 80-day-old final control group (Cf). Each hemimandible was histologically processed to analyse parameters associated with root development. Statistical analysis was carried by means of ANOVA; p values below 0.05 were considered statistically significant. Results: baseline (i.e. 25-days old) mean root length and apical diameter of the distal root canal were 1.84±0.25 and 0.38±0.02mm respectively. Following the regenerative endodontic protocol, cells lining the walls of the root canal and significant increase to both length (2.37±0.22mm) and diameter (0.32±0.03 mm) were observed. Conclusions: newly-weaned Wistar rats serve as a suitable model to evaluate regenerative endodontic protocols. However, further research is needed in order to disclose the nature of the cells and/or cell mediators involved.
Os descendentes de imigrantes italianos rumo a terra dos seus antepassados
Authors: Nicoli Sandra , Santos Mauro Augusto dos , Siqueira Sueli
Published: July 2021

No Brasil, o projeto imigrantista a partir da segunda metade do século XIX, era baseado na pequena propriedade familiar. Minas Gerais foi destino secundário das famílias de imigrantes italianos. Nesse contexto, Itueta e Santa Rita do Itueto receberam, no início do século XX, famílias de imigrantes italianos oriundas do Norte da Itália, principalmente da região do Vêneto. Essas famílias promoveram uma nova configuração a esse território, inserindo novas técnicas de manejo da terra e novos costumes. A partir do final do século XX, outro movimento migratório é realizado pelos descendentes das gerações mais novas, desta vez em direção à terra de seus avós, a Itália. Através de entrevistas em profundidade realizadas com os descendentes que emigraram para a Itália e retornaram ao Brasil, buscou-se compreender suas razões para emigrar, o cotidiano no destino e como perceberam sua italianidade na terra dos seus antepassados e, no retorno, qual a percepção de sua brasilidade. Em terras italianas, como lidaram com a situação de serem estrangeiros brasileiros e, ao mesmo tempo, descendentes de italianos. Os dados demonstram que se antes de emigrar consideravam-se descendentes, no retorno reafirmam sua identidade de brasileiros, pois no destino entendem que toda sua italianidade não é reflexiva.
Critical Overview of Probiotics Efficacy on Health and its Safety
Authors: Bhargab Deka  , Biswajit Dash  , Bhanita Saud  , Bedanta Bhattacharjee  , Abu Md Ashif Ikbal
Published: July 2021

The review is to analyse the therapeutic benefits of probiotics in various chronic disorders. All the data were identified using PUBMED (2000-2020) and bibliographic reviews of recent and old articles from an English literature search. After independent analysis by co-authors of the identified articles, data were analysed and extracted for the stated purpose.The most-studied species include Lactobacillus, Bifidobacterium, and Saccharomyces. Probiotics have an essential role in maintaining immunologic equilibrium in the gastrointestinal tract through direct interaction with immune cells. There is high-quality evidence that probiotics are effective for acute infectious diarrhoea, antibiotic-associated diarrhea, Clostridium difficile associated diarrhoea, hepatic encephalopathy, ulcerative colitis, irritable bowel syndrome, and necrotizing enterocolitis. Probiotics are safe for infants, children, adults, and older patients.Therapeutic applications of probiotics have been widely studied to treat and improve the gut's health; however, choosing a probiotic for a specific condition is a challenging task that requires parsing of the data for strain-specific efficacy and evaluation of product quality. It appears likely that more national organizations will be conducting evidence-based research, and the pharmacist and clinicians should pay attention to this ever-changing field.
Severe Acute Malnutrition: Impact and Prevention
Authors: Bharti Vishwakarma  , Anjana Fellows
Published: July 2021

The severe acute Malnutrition has been related with deficiency, poor diet and inadequate access to health care, and it remains as universal health issue that contributes to ill-health with 50% of childhood deaths due to underlying malnutrition. Bio fortification, probiotic foods and food process methods have shown the potential to beat the deficiency disease. A recently developed home primarily based treatment for severe acute deficiency disease is convalescent the lives of many thousands of kids a year. Ready-touse Therapeutic Food has modified radically the treatment of severe deficiency disease – providing foods that are safe to use reception and guarantee fast weight gain in severely malnourished youngsters. It has been observed that the household size, household food access, and the child’s age were the major predictors of severe acute malnutrition. Engaging poor families in kitchen gardening to ensure household food access and nutritious diet to the children, along with health education and promotion to the mothers of young children are therefore recommended to reduce child undernutrition.
The jubilee of Academician Leonid Barbarash
Authors: Editorial Article
Published: July 2021

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Targeting BRF2 in Cancer Using Repurposed Drugs
Authors: Rashidieh Behnam , Molakarimi Maryam , Mohseni Ammar , Tria Simon , Srihari Sriganesh , Adams Rachael C. , Duijf Pascal H.G. , Jones Mathew , Khanna Kum Kum
Published: July 2021

Overexpression of BRF2, a selective subunit of RNA polymerase III, has been shown to be crucial in the development of several types of cancers, including breast cancer and lung squamous cell carcinoma . Predominately, BRF2 acts as a central redox-sensing transcription factor (TF) and is involved in rescuing oxidative stress (OS) -induced apoptosis. Here, we showed a novel link between BRF2 and DNA damage response. Due to the lack of BRF2 specific inhibitors, through virtual and molecular dynamics screening, we identified potential drug candidates that interfere with BRF2-TATA-binding Protein (TBP)-DNA complex interactions based on binding energy, intermolecular, and torsional energy parameters. We experimentally tested Bexarotene as a potential BRF2 inhibitor. We found that Bexarotene (Bex) treatment resulted in a dramatic decline in oxidative stress (Tert-butylhydroquinone (tBHQ))-induced levels of BRF2 and consequently, lead to a decrease in cellular proliferation of cancer cells which may in part be due to drug pretreatment induced reduction of ROS generated by the oxidizing agent. Our data thus, provide the first experimental evidence that BRF2 is a novel player in DNA damage response pathway and Bexarotene can be used as a potential inhibitor to treat cancers with the specific elevation of oxidative stress.
One-step nucleic acid amplification (OSNA) of Sentinel Lymph Node in Early Stage Endometrial Cancer: Spanish Multicenter Study (ENDO-OSNA).
Authors: Diestro M. D. , Berjón A. , Zapardiel I. , Yébenes L. , Ruiz I. , Lekuona A. , Rezola M. , Jaunarena I. , Siegrist J. , Sánchez-Pastor M. , Cuadra M. , Sagasta A. , Guerra I. , Lete L. I. , Roldán F. , Marta C.-B. , Boillos M. J. , Cardiel M. J. , López-de la Manzanara C. , Relea F. , Coronado P. J. , Pascual A. , Román M. J. , Peiró G. , Matute L. J. , Montero B. , Muruzábal J. C. , Guarch R. , Zorrero C. , Calatrava A. , Ribot L. , Costa I. , Hernández A. , Hardisson D.
Published: July 2021

The objective of this study was to evaluate the efficacy of one-step nucleic acid amplification (OSNA) for the detection of sentinel lymph node (SLN) metastasis compared to standard pathological ultrastaging in patients with early-stage endometrial cancer (EC). A total of 526 SLNs from 191 patients with EC were included in the study. 379 SLNs (147 patients) were evaluated by both methods, OSNA and standard pathological ultrastaging. The central 1-mm portion of each lymph node was subjected to semi-serial sectioning at 200-μm intervals and examined by hematoxylin-eosin and immunohistochemistry with CK19; the remaining tissue was analysed by OSNA for CK19 mRNA. The OSNA assay detected metastases in 19.7% of patients (14.9% micrometastasis and 4.8% macrometastasis), whereas pathological ultrastaging detected metastasis in 8.8% of patients (3.4% micrometastasis and 5.4% macrometastasis). Using the established cut-off value for detecting SLN metastasis by OSNA in EC (250 copies/μl), the sensitivity of the OSNA assay was 92%; specificity was 82%; diagnostic accuracy was 83%, and the negative predictive value was 99%. Discordant results between both methods were recorded in 20 patients (13.6%). OSNA resulted in an upstaging in 12 patients (8.2%). OSNA could aid in the identification of patients requiring adjuvant treatment at the time of diagnosis.
The Metabolic Flux Probe (MFP) - Secreted Protein as a Non-Disruptive Information Carrier for 13C-Based Metabolic Flux Analysis
Authors: Dusny Christian , Schmid Andreas
Published: July 2021

Novel cultivation technologies demand the adaptation of existing analytical concepts. Metabolic flux analysis (MFA) requires stable-isotope labeling of biomass-bound protein as the primary information source. Obtaining the required protein in cultivation set-ups where biomass is scarce or inaccessible due to low cell densities and cell immobilization is difficult to date. We developed a non-disruptive analytical concept for 13C-based metabolic flux analysis based on secreted protein as an information carrier for isotope mapping in the protein-bound amino acids. This "metabolic flux probe" (MFP) concept was investigated in different cultivation set-ups with a recombinant, protein-secreting yeast strain. The obtained results grant insight into intracellular protein turnover dynamics. Experiments under metabolic but isotopically nonstationary conditions in continuous glucose-limited chemostats at high dilution rates demonstrated faster incorporation of isotope information from labeled glucose into the recombinant reporter protein than in biomass-bound protein. Our results suggest that the reporter protein was polymerized from intracellular amino acid pools with higher turnover rates than biomass-bound protein. The latter aspect might be vital for 13C-flux analyses under isotopically nonstationary conditions for analyzing fast metabolic dynamics.
Multi-Criteria Analysis of Green Bonds: A Hybrid Ahp–Copras Application
Authors: Lombardi Netto Antonio , Salomon Valerio Antonio Pamplona , Ortiz-Barrios Miguel
Published: July 2021

There is an increasing pressure by community and customers forcing companies to insert environmental concerns in their practices. To help companies initiatives, the green bonds market was incepted. Our research question is how to select bonds in a growing billion-dollar market. This paper presents a multi-criteria decision analysis (MCDA) model to enable investors identify opportunities based not only in opinions, but grounded on objective facts. Analytic Hierarchy Process (AHP) and Complex Proportional Assessment (COPRAS) are two MCDA methods applied in this paper. Top-fifteen green bonds ranked by specialized media were assessed with the proposed MCDA model. Criteria included the Environmental Performance Index (EPI) proposed by Yale University, and common financial indicators as assets, risks (β), and dividends. The new AHP–COPRAS rank is compared with another published by specialized media.
Goal-Driven Visual Question Generation from Radiology Images
Authors: Sarrouti Mourad , Abacha Asma Ben , Demner-Fushman Dina
Published: July 2021

Visual Question Generation (VQG) from images is a rising research topic in both fields of natural language processing and computer vision. Although there are some recent efforts towards generating questions from images in the open domain, the VQG task in the medical domain has not been well-studied so far due to the lack of labeled data. In this paper, we introduce a goal-driven VQG approach for radiology images called VQGRaD that generates questions targeting specific image aspects such as modality and abnormality. In particular, we study generating natural language questions based on the visual content of the image and on additional information such as the image caption and the question category. VQGRaD encodes the dense vectors of different inputs into two latent spaces, which allows generating, for a specific question category, relevant questions about the images, with or without their captions. We also explore the impact of domain knowledge incorporation (e.g., medical entities and semantic types) and data augmentation techniques on visual question generation in the medical domain. Experiments performed on the VQA-RAD dataset of clinical visual questions showed that VQGRaD achieves 61.86% BLEU score and outperforms strong baselines. We also performed a blinded human evaluation of the grammaticality, fluency, and relevance of the generated questions. The human evaluation demonstrated the better quality of VQGRaD outputs and showed that incorporating medical entities improves the quality of the generated questions. Using the test data and evaluation process of the ImageCLEF 2020 VQA-Med challenge, we found that relying on the proposed data augmentation technique to generate new training samples by applying different kinds of transformations, can mitigate the lack of data, avoid overfitting, and bring a substantial improvement in medical VQG.
Review on the Integration of Microelectronics for E-textile
Authors: Simegnaw Abdella Ahmmed , Malengier Benny , Rotich Gideon K. , Tadesse Melkie Getnet , Van Langenhove Lieva
Published: July 2021

Modern electronic textiles are moving towards flexible wearable textiles, so-called e-textiles that have micro-electronic elements embedded onto the textile fabric that can be used for varied classes of functionalities. There are different methods of integrating rigid microelectronic components into/onto textiles for the development of smart textiles, which include, but are not limited to, physical, mechanical and chemical approaches. The integration systems must satisfy being flexible, lightweight, stretchable and washable to offer a superior usability, comfortability and non-intrusiveness. Furthermore, the resulting wearable garment needs to be breathable. In this review work, three levels of integration of the microelectronics into/onto the textile structures are discussed, the textile-adapted, the textile-integrated, and the textile-based integration. The textile-integrated and the textile- adapted e-textiles have failed to efficiently meet being flexible and washable. To overcome the above problems, researchers studied the integration of microelectronics into/onto textile at fiber or yarn level applying various mechanisms. Hence, a new method of integration, textile-based, has risen to the challenge due to the flexibility and washability advantages of the ultimate product. In general, the aim of this review is to provide a complete overview of the different interconnection methods of electronic components into/onto textile substrate.
Dietary Sodium and Potassium Intake: Data from the Mexican National Health and Nutrition Survey 2016
Authors: Vargas-Meza Jorge , Cervantes-Armenta Manuel A. , Campos-Nonato Ismael , Nieto Claudia , Marrón-Ponce Joaquín Alejandro , Barquera Simón , Flores-Aldana Mario , Rodríguez-Ramírez Sonia
Published: July 2021

Population studies have demonstrated an association between sodium (Na) and po-tassium (K) intake and levels of blood pressure (BP) and cholesterol. The aim of this study was to describe the dietary intake and distribution of Na and K in Mexicans, and their as-sociation with metabolic risk outcomes. We analyzed a national survey that included 4,219 participants. Dietary information was obtained through a 24-hour recall. Foods and beverages were classified based on the degree of processing. BP and biomarkers in blood and urine were measured. The mean intake (mg/d) of Na was 1512 in pre-schoolchildren, 2844 in schoolchildren, 3743 in adolescents, and 3132 in adults. The mean intake of K was 1616 in pre-schoolchildren, 2256 in schoolchildren, 2967 in adolescents, and 3401 in adults. Processed and ultra-processed foods (UPF) contribute to sodium intake: 49% in preschool and schoolchildren, 47% in adolescents, and 39% in adults. Adults in the fourth quartile of sodium intake had lower serum concentrations of cholesterol (181.4 mg/dL) and HDL-c (35.5 mg/dL). The Mexican population has high Na and low K intakes. There is a relationship between Na sodium consumption and cholesterol, and LDL levels. UPF contributes to almost 40% of the sodium consumed by Mexicans.
The Metaphysics and Theology of Music
Authors: Chira Vasile
Published: July 2021

This article aims to analyze music from a philosophical and theological perspective, using the principles of multi- and transdisciplinary methodology. After a brief introduction, which presents the main moments in the history of the musical phenomenon, a first chapter addresses the metaphysical dimension of music in classical composers. The second chapter shows the position of philosophers towards music, starting with Pythagoras and ending with Schopenhauer. The third chapter focuses on music theology in general, but also on the theology and metaphysics of music to the French philosopher of Romanian origin, Emil Cioran, who, after Augustin and Schopenhauer, wrote probably the deepest pages on the ontology of music. The last chapter refers to to the archetypal character of music.
Can Leader Humility Enhance Project Management Effectiveness? Interactive Effect of Top Management Support
Authors: Ali Mudassar , Li Zhang , Zhenduo Zhang , Zada Muhammad , Begum Abida , Han Heesup , Montes Antonio Ariza , Muñoz Alejandro Vega
Published: July 2021

This paper aims to explore the effect of humble leadership on project success by integrating the mediating role of employee creativity. Top management support moderates the direct relationship (humble leadership and project management effectiveness) and indirect relationships through employee creativity. Time-lagged data were obtained from 332 persons working in the matrix organization across the information technology. The results showed that humble leadership enhance project management effectiveness by mediating and moderating processes. This study provides a solution to an underlying research question that has gone unanswered in prior studies. What are the strategies proposed for humble leadership in fostering the effectiveness of the project?
Melatonin/Nanoclay Hybrids for Skin Delivery
Authors: Borrego-Sánchez Ana , Muñoz-Santiburcio Daniel , Viseras César , Hérnandez-Laguna Alfonso , Sainz-Díaz C. Ignacio
Published: July 2021

Melatonin is a hormone used for treating several disorders. However, its oral administration is problematic due to the variable absorption and extensive first-pass metabolism. The topical application of this drug does not present these disadvantages and can be used for therapeutic and skin protection purposes. The adsorption and release of melatonin in the montmorillonite clay was investigated experimentally and theoretically. The drug-clay interaction products were prepared and characterized, showing a modified and improved diffusion and release of melatonin. The crystal structure and spectroscopic properties of melatonin and melatonin-water-mineral materials were studied by molecular modeling, finding that the adsorption of this drug is energetically favourable, and the results were consistent with the experimental data. Ab initio molecular dynamics simulations with the metadynamics methodology showed the release of melatonin from the confined interlayer nanospace of montmorillonite to the liquid bulk water with a 20 kcal/mol free energy barrier.
Sustainable Infrastructure 4.0 - Value Chain Integration through Federated Digital Platforms
Authors: Nübel Konrad , Bühler Michael , Jelinek Thorsten
Published: July 2021

Twenty-first century infrastructure needs to respond to changing demographics, becoming climate neutral, resilient, and economically affordable, while remaining a driver for development and shared prosperity. However, the infrastructure sector remains one of the least innovative and digitalized, plagued by delays, cost overruns, and benefit shortfalls [1-4]. The root cause is the prevailing fragmentation of the infrastructure value chain [5]. To support overcoming the shortcomings, an integration of the value chain is needed. This could be achieved through a use-cased-based creation of federated digital platforms applied to infrastructure projects. Such digital platforms enable full-lifecycle participation and responsible governance guided by a shared infrastructure vision.
Implemented New Technologies within the Complexity of Medical Rehabilitations: Improvement of Mental Health and Synergetic Outcomes with Healthcare Service Effects
Authors: Keller Franziska Maria , Dahmen Alina , Derksen Christina , Kötting Lukas , Lippke Sonia
Published: July 2021

The need for new technologies into healthcare services has been stressed. However, little is known about the effectiveness of digital interventions integrated in psychosomatic rehabilitation processes. Data from 724 patients from psychosomatic rehabilitation clinics were analyzed for effectiveness of digital trainings examined by a change in symptoms related to depression, anxiety, stress and loneliness from pre- to post-rehabilitation. Rehabilitation satisfaction was examined in association with reaching rehabilitation goals and satisfaction with communication. Mixed repeated measures analysis of covariances, analysis of covariances, and hierarchical stepwise regression analyses were performed. Results indicated a superior effectiveness for the intervention group receiving all offered digital treatments in addition to the regular face-to-face rehabilitation program with regard to symptoms of depression, F(2,674)=3.93, p<.05, ηp2=.01), and anxiety, F(2,678)=3.68, p<.05, ηp2=.01), post-rehabilitation with large effect sizes for both depression (d=1.28) and anxiety (d=1.08). In addition, rehabilitation satisfaction was positively associated with reaching rehabilitation goals and perceived communication with healthcare workers. Digital interventions appeared effective in supporting mental health of psychosomatic rehabilitation patients post-rehabilitation. This finding supports the inclusion of multidisciplinary and interdisciplinary digital and face-to-face treatment programs and call for more implementations of new technologies in a context of complexity to improve health and healthcare service.
A pulse of mercury and major ions in snowmelt runoff from a small Arctic Alaska watershed
Authors: Douglas Thomas , Sturm Matthew , Blum Joel , Polashenski Christopher , Stuefer Svetlana , Hiemstra Christopher , Steffen Alexandra , Filhol Simon , Prevost Romain
Published: July 2021

Atmospheric mercury (Hg) is deposited to Polar Regions during springtime atmospheric mercury depletion events (AMDEs) that require halogens and snow or ice surfaces. The fate of this Hg during and following snowmelt is largely unknown. We measured Hg, major ions, and stable water isotopes from the snowpack through the entire spring melt runoff period for two years. Our small (2.5 ha) watershed is near Barrow (now Utqiaġvik), Alaska. We measured discharge, made 10 000 snow depths, and collected over 100 samples of snow and meltwater for chemical analysis in 2008 and 2009 from the watershed snowpack and ephemeral stream channel. Our results suggest AMDE Hg complexed with Cl⁻ or Br⁻ may be less likely to be photochemically reduced and re-emitted to the atmosphere prior to snowmelt, and we estimate that roughly 25% of the Hg in snowmelt is attributable to AMDEs. Projected Arctic warming, with more open sea ice leads providing halogen sources that promote AMDEs, may provide enhanced Hg deposition, reduced Hg emission and, ultimately, an increase in snowpack and snowmelt runoff Hg concentrations.
Cost-Utility Analysis of Expanding Hepatitis B Vaccination Among Healthcare Workforce in Ethiopia
Authors: Tewihubo Dinksew , Gebrehans Micheale , Asmamaw Getahun
Published: July 2021

Objective Ethiopia is one of the countries with high endemicity of hepatitis B infection. In Ethiopia, the current vaccine coverage among health care workers accounts for around 14%. Most health workforce (241,250) of Ethiopia was first considered as susceptible with a probability of getting Hepatitis B Virus acutely and 5–10% chance of progressing to chronic Hepatitis B. Hence, examining cost-utility analysis of hepatitis B vaccination coverage among healthcare workers in Ethiopia was found the most essential work.Method Markov model for expanding vaccination coverage (3 doses of hepatitis B vaccine) was simulated based on the data obtained both primary and secondary data. A secondary data particularly cost and effectiveness data were obtained from published articles, World Health Organization (WHO) guidelines and Ethiopian Federal Ministry of Health (FMOH) documents. Moreover, cost related data for vaccination and chronic hepatitis B treatment were also gathered by interviewing expertise from Tikur Anbesa Specialized Hospital (TASH). This study was conducted from a healthcare payer perspective, with 3% discount rate of cost and health outcome as WHO recommendation. Primarily health outcome was measured by Quality Adjusted Life Year (QALY) gain and Incremental Cost-Effectiveness Ratio (ICER). Deterministic analysis and tornado diagrams were employed to manage parameter uncertainty and show a plausible range of cost and effectiveness of variables.Result Current vaccination program is more expensive (USD 29.99) with a positive incremental cost of USD 1.32 and less effective that have negative incremental effectiveness of -0.08 and total life year gains of 28.54 than Expanded Hepatitis B vaccination strategy which costs USD 28.67 and gives relatively high total life-year gain of 28.62. The resulting ICER was USD 16.23 per QALY gained. However, the ICER was a negative for the current vaccination strategy that could show, it was dominated by the Expanded Hepatitis B vaccination strategy. One-way sensitivity analysis also provided that the current vaccine coverage was dominated for an increase in the risk of infection among unvaccinated individuals.Conclusion Increasing current vaccine coverage from 14% to no less than 80% across Ethiopian healthcare workforces would be the most cost-effective strategy.
Random forest and extreme gradient boosting algorithms for streamflow modeling using vessel features, and tree-rings
Authors: Sahour Hossein , Gholami Vahid , Torkman Javad , Vazifedan Mehdi , Saeedi Sirwe
Published: July 2021

Monitoring temporal variation of streamflow is necessary for many water resources management plans, yet, such practices are constrained by the absence or paucity of data in many rivers around the world. Using a permanent river in the north of Iran as a test site, a machine learning framework was proposed to model the streamflow data in the three periods of growing seasons based on tree-rings and vessel features of the Zelkova carpinifolia species. First, full-disc samples were taken from 30 trees near the river, and the samples went through preprocessing, cross-dating, standardization, and time series analysis. Two machine learning algorithms, namely random forest (RF) and extreme gradient boosting (XGB), were used to model the relationships between dendrochronology variables (tree-rings and vessel features in the three periods of growing seasons) and the corresponding streamflow rates. The performance of each model was evaluated using statistical coefficients (coefficient of determination (R-squared), Nash-Sutcliffe efficiency (NSE), and root-mean-square error (NRMSE)). Findings demonstrate that consideration should be given to the XGB model in streamflow modeling given its apparent enhanced performance (R-squared: 0.87; NSE: 0.81; and NRMSE: 0.43) over the RF model (R-squared: 0.82; NSE: 0.71; and NRMSE: 0.52). Further, the results showed that the models perform better in modeling the normal and low flows compared to extremely high flows. Finally, the tested models were used to reconstruct the temporal streamflow during the past decades (1970–1981).
Annealing Accelerator for Ising Spin Systems based on In-memory Complementary 2D FETs
Authors: Sebastian Amritanand , Das Sarbashis , Das Saptarshi
Published: July 2021

Metaheuristic algorithms such as simulated annealing (SA) has been implemented for optimization in combinatorial problems, especially for discreet problems. SA employs a stochastic search, where high-energy transitions (“hill-climbing”) are allowed with a temperature-dependent probability to escape local optima. Ising spin glass systems have properties such as spin disorder and “frustration” and provide a discreet combinatorial problem with high number of metastable states and ground-state degeneracy. In this work, we exploit subthreshold Boltzmann transport in complementary two-dimensional (2D) field effect transistors (p-type WSe2 and n-type MoS2) integrated with analog, non-volatile, and programmable floating-gate memory stack to develop in-memory computing primitives necessary for energy and area efficient hardware acceleration of SA for the Ising spin systems. We experimentally demonstrate > 800X search acceleration for 4×4 ferromagnetic, antiferromagnetic, and a spin glass system using SA compared to an exhaustive search using brute force trial at miniscule total energy expenditure of ~120 nJ. Our hardware realistic numerical simulations further highlight the astounding benefits of SA in accelerating the search for larger spin lattices.