bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic analysis of blood serum – a new approach to the search for diagnostic markers of bronchial asthma in
children
Authors: Lebedenko A. A. , Afonin A. A. , Semernik Olga E. , Loginova I. G. , Gunko V. O. , Larichkin A. V. , Alliluyev I. A. , Galkina G. A. , Panova I. V.
Published: February 2022

Currently, bronchial asthma (BA) is one of the most pressing medical and social problems, the molecular aspects of the formation and development of BA are insufficiently studied and the diagnosis is not perfect. Carrying out proteomic analysis of BA will not only reveal new biomarkers specific to this disease, but also bring us closer to understanding its pathogenetic mechanisms. The purpose of the study: to study the proteomic profile of blood serum of children with BA to identify proteins associated with this disease A comprehensive clinical and laboratory examination of children suffering from BA and control group patients was performed. Proteomic analysis of depleted blood serum included high-resolution two-dimensional electrophoresis (1 direction: immobiline strips 17cm, pH 3-10, 2 direction: denaturing electrophoresis in 12.5% polyacrylamide gel), protein staining on gels with fluorescent dye Flamingo, protein identification by MALDI-TOF mass spectrometry using the search algorithm Mascot and the Swiss-Prot database. Comparison of the proteomic profile of BA serum and the control group patients serum allowed us to establish that the production of a number of proteins is reduced in this pathology. Among them, proteins in the molecular weight range of 16-33 kDa (p<0.05) were identified: glutathione peroxidase 3, transtyretin, complement components C4b and C3. Research shows that changes in the children’s serum proteome occur in BA, affecting proteins that play an important role in immune responses, ligand transport, and antioxidant protection. Special attention should be paid to the differences identified in the course of this work (glutathione peroxidase, transtyretin, C3 and C4 fragments of the complement system) or their combinations. Studying the features of their expression will expand our understanding of the molecular mechanisms underlying chronic inflammation of this disease.
About quantitative determination of the D-dimer in the blood by immunochromatographic method
Authors: Akinshina Yulia Aleksandrovna , Mardanly S. G. , Rotanov S. V. , Pomazanov V. V. , Kiseleva V. A.
Published: February 2022

The paper presents the results of the development of a technology for the quantitative determination of D-dimer in blood with an immunochromatographic (LFIA) kit of reagents «LFIA-D-dimer» and instrument accounting of the results. Registration and processing of the digitized indicator of the intensity of staining of the LFIA-test strip using the LFIA-analyzer software allows quantifying the D-dimer content in the sample (in ng DDU/ml). The effectiveness of the proposed approach was evaluated on 258 clinical samples examined in the LFIA with visual and instrument accounting of the results, in comparison with the indicators of D-dimer determination in ELISA. The high reproducibility of the digitized LFIA results was shown - the coefficient of variation (CV) for samples in the range of 100-300 ng DDU/ml (near-threshold in relation to pathological values) was 2.5-5.1%; a tendency to increase CV with a further increase in the concentration of D-dimer was traced. A high correlation of the digitized LFIA result with the research data in the ELISA has been established, which makes it possible to recommend the technology for widespread use in urgent medicine.
PENGGUNAAN MADU UNTUK PENYEMBUHAN LUKA PADA PASIEN DIABETIC FOOT ULCER (DFU): LITERATURE REVIEW
Authors: Prima Ashar , Putra Qiantara , Yusrini Yusrini
Published: February 2022

Abstrak

Tujuan: Tujuan penelitian ini adalah mengetahui efektifitas penggunaan madu sebagai dressing dalam penyembuhan luka pada pasien DFU berdasarkan literatur. Metode:  Karya tulis ilmiah ini merupakan studi literatur pencarian menggunakan database elektronik google Schoolar, semantik Schoolar, dan PubMed. Kata kunci yang digunakan dalam pencarian adalah Diabetic Foot Ulcer atau Ulkus Kaki Diabetik, Honey atau Madu, Wound Healing atau Penyembuhan Luka. Kriteria inklusi yang digunakan dalam artikel dapat diakses, naskah full text, dalam bahasa Inggris dan bahasa Indonesia, gratis, tahun jurnal yang digunakan dibatasi 10 tahun terakhir. Hasil: ditemukan masing-masing 1 Pubmed, 2 google Schoolar, dari 3 artikel membahas penggunaan madu untuk penyembuhan luka pada pasien ulkus kaki diabetik. Hasil: Hasil studi literatur menunjukkan bahwa 3 artikel melaporkan bahwa madu dapat mempercepat penyembuhan luka pada pasien ulkus kaki diabetik karena madu dapat merangsang pertumbuhan granulasi, bersifat antibakteri, dan melembabkan luka. Kesimpulan: Berdasarkan hasil studi literatur, dapat disimpulkan bahwa dari 3 artikel yang menyatakan bahwa pemberian madu memiliki efektifitas terhadap penyembuhan luka pada pasien ulkus kaki diabetik.

Kata Kunci: Kaki Diabetik, Madu Penyembuhan Luka

 

Abstract

Objective: The purpose of this study was to determine the effectiveness of the use of honey for wound healing in diabetic foot ulcer patients based on a literature search Methods: This scientific paper was a search literature study using an electronic database google scholar, semantic scholar, and PubMed. The keywords used in the search were Diabetic Foot Ulcer or Diabetik Ulkus Pada Kaki, Honey or Madu, Wound healing or Penyembuhan Luka. The inclusion criteria used in the article are accessible, full-text manuscript, in English and Indonesian, free of charge, the journal year used is limited to the last 10 years, the results are found each 1 PubMed, 2 google scholar, from 3 articles discussing the use of honey for wound healing in diabetic foot ulcer patients. Results:   The results of the literature study showed that the 3 articles reported that honey can accelerate wound healing in diabetic foot ulcer patients because honey can stimulate granulation growth, be antibacterial, and moisturize wounds.Conclusion:   Based on the results of the literature study, it can be concluded that 3 articles stated that the administration of honey has an effect on wound healing in diabetic foot ulcer patients.

Keywords:  Diabetic Foot Ulcer, Honey, Wound Healing
MENINGKATKAN PENGETAHUAN MASYARAKAT MELALUI PROGRAM PENYULUHAN SOKRATIK-DEMONSTRASI
Authors: Erika Erika , Asni Arti Nur , Fridayana Fitri Rahma
Published: February 2022

Pandemi Covid-19 telah memicu terjadinya anxiety (gangguan kecemasan), yang diakibatkan oleh munculnya rasa takut akan tertular Covid-19, sehingga mempengaruhi berbagai aspek kehidupan masyarakat. Indonesia merupakan salah satu negara dengan tingkat infeksi COVID-19 yang tinggi dikarenakan adanya berbagai masalah. Masalah-masalah ini sangat umum di kalangan penduduk. Salah satunya berkaitan dengan kesadaran masyarakat, kecemasan dan kurangnya pengetahuan masyarakat tentang ancaman pandemi Covid-19. Hal ini terlihat dari kurangnya kesadaran masyarakat akan isu menjaga kebersihan dan perlindungan terhadap Covid19. Meski sudah diimbau oleh kepala desa dan staf untuk mengikuti protokol kesehatan, masyarakat yang  keluar rumah tanpa menggunakan masker masih banyak ditemui di tempat-tempat umum. Ini adalah tugas penting  untuk menekan penyebaran kasus positif COVID-19. Dalam situasi ini, perlu untuk meningkatkan kesadaran masyarakat untuk mencegah infeksi COVID-19. Tujuan dari penulisan artikel ini adalah untuk menilai efektivitas metode konseling empiris Socrates. Metode penyuluhan dilakukan pada 30 orang di desa Lestaridadi untuk dipublikasikan di jurnal.
PENGUATAN KINERJA MELALUI PELATIHAN PRE DAN POST CONFERENCE PADA PERAWAT DI RSU FULL BETHESDA
Authors: Kartika Hasibuan Eva , Amila Amila , Sembiring Evarina
Published: February 2022

Pre conference merupakan diskusi tentang aspek klinik sebelum melaksanakan asuhan keperawatan pada pasien dan post conference yaitu diskusi tentang aspek klinik sesudah melaksanakan asuhan keperawatan pada pasien. Berdasarkan observasi dan wawancara penulis dengan perawat ruangan di RSU Full Bethesda, pelaksanaan pre dan post conference belum dilakukan secara optimal, jika hal ini dilakukan secara continue, maka akan berpengaruh pada asuhan keperawatan yang diberikan perawat dan akhirnya berdampak pada mutu pelayanan Rumah Sakit. Kegiatan ini bertujuan untuk menambah pengetahuan dan skill perawat dalam menerapkan pre dan post conference. Pelaksanaan metode kegiatan pertama sekali dengan penyampaian materi terkait bahan kajian yang perlu disampaikan setelah itu melaksanakan roleplay pre dan post conference yang dilaksankan selama 3 hari. Hasil yang didapatkan setelah dilakukan sosialisasi dan praktek menunjukkan 90 % perawat paham terkait penjelasan materi dan 95% perawat dapat mempraktekkan pre dan post conference
FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN MUTU PELAYANAN KESEHATAN DI RUMAH SAKIT STELLA MARIS BINTANG LAUT KECAMATAN TELUK DALAM KABUPATEN NIAS SELATAN
Authors: Dakhi Tiwanto , Nyorong Mappeaty , Harahap Juliandi
Published: February 2022

Rumah sakit memiliki peran yang sangat strategis dalam upaya mempercepat peningkatan derajat kesehatan masyarakat. Paradigma baru pelayanan kesehatan mensyaratkan rumah sakit memberikan pelayanan berkualitas sesuai kebutuhan dan keinginan pasien dengan tetap mengacu pada kode etik profesi dan medis. Tujuan penelitian untuk mengetahui hubungan reliability, assurance, tangibles, emphaty, responsiveness dengan mutu pelayanan kesehatan di Rumah Sakit Stella Maris Bintang Laut Kecamatan Teluk Dalam Kabupaten Nias Selatan. Desain penelitian menggunakan metode kuantitatif yang dilakukan survei analitik dengan pendekatan cross sectional study. Populasi dalam penelitian ini adalah pasien yang datang berobat yaitu 512 responden. Sampel menggunakan sistem accidental sampling sebanyak 83 pasien. Analisis data menggunakan analisis univariat, bivariat dan multivariat. Hasil penelitian menunjukkan variabel reliability p = 0,010, assurance p = 0,027, tangibles p = 0,000, empathy p = 0,027, responsiveness p = 0,000. Sedangkan faktor yang dominan yang berhubungan dengan mutu pelayanan adalah responsiveness p = 0,000, 95% CI = 6,092-154,611 dengan OR 30,691. Kesimpulan dari penelitian ini adalah ada hubungan reliability, assurance, tangible, emphaty, responsiveness dengan pelayanan di Rumah Sakit Stella Maris Bintang Laut Kecamatan Teluk Dalam Kabupaten Nias Selatan. Disarankan kepada Rumah Sakit Stella Maris Bintang Laut Kecamatan Teluk Dalam Kabupaten Nias Selatan agar meningkatakan mutu pelayanan pada dimensi responsiveness, yang dirasa kurang baik dari pemberi pelayanan (petugas kesehatan) kepada pasien rawat jalan dalam hal ini dapat memberikan pelatihan kepada petugas kesehatan agar lebih memaksimalkan dan mempertahankan kualitas yang sudah baik agar kepuasan pelayanan kesehatan pasien dapat tercapai secara maksimal.
FAKTOR-FAKTOR YANG MEMENGARUHI HYGIENE GENITALIA PADA REMAJA PUTRI SAAT MENSTRUASI DI PONDOK PESANTREN DAIRI SIDIKALANG TAHUN 2021
Authors: Berampu Lusiana , Lumbanraja Sarma , Asriwati Asriwati
Published: February 2022

WHO melaporkan bahwa kanker serviks adalah kanker yang paling umum keempat dikalangan wanita dengan kasus tahun 2018 sebesar 570.000. Strategi global untuk menghilangkan kanker serviks oleh WHA dengan merekomendasikan pendekatan komprehensif melalui strategi preventif primer pada anak laki-laki dan perempuan mencakup pendidikan seks disesuaikan dengan usai dan budaya. Tujuan penelitian untuk menganalisis pengaruh pengetahuan, sikap, sumber informasi, dukungan guru/ustadzah, dukungan keluarga dan faktor yang paling berpengaruh terhadap Hygiene Genitalia pada remaja putri saat menstruasi di Pondok Pesantren Dairi Sidikalang Tahun 2021.
Metode penelitian menggunakan survey analitik dengan pendekatan cross sectional. Populasi sebanyak 101 remaja putri dengan teknik pengambilan sampel menggunakan total populasi. Data dikumpulkan menggunakan kuesioner dan analisa data adalah univariat, bivariat dan multivariat.
Hasil penelitian menggunakan uji regresi linier berganda menunjukkan nilai sig pengatahuan 0,008 OR=22,920 CI 2,231-235,477, sikap 0,005 OR=4,471 CI 1,573-12,707, sumber informasi 0,008 OR=4,428 CI 1,474-13,306, dukungan guru/ustadzah 0,013 OR=3,645 CI 1,316-10.099, dan dukungan keluarga 0,971 OR=0,981 CI 0,336-2,858.
Kesimpulan ada pengaruh pengetahuan, sikap sumber infromasi, dukungan guru/ustadzah dan tidak ada pengaruh dukungan keluarga terhadap hygiene genitalia pada remaja putri saat menstruasi. Variabel paling berpengaruh adalah pengetahuan. Diharapkan kepada dinas pendidikan/Depag membuat sebuah kebijakan tentang kurikulum kesehatan reproduksi kepada remaja untuk mendukung pengetahuan, sikap dan tindakan anak remaja berkaitan dengan kesehatan terutama reproduksinya dan berkomitmen dengan dinas kesehatan untuk menyediakan tenaga kesehatan dan tenaga pendidik basic kespro untuk berkordinasi dalam memberikan KIE kepada remaja.
CARDIAC RESYNCHRONIZATION THERAPY IN CHRONIC HEART FAILURE WITH ATRIAL FIBRILLATION: ANALYSIS AND RESULT PREDICTION
Authors:   Republican Scientific and Practical Centre of Cardiology, A. Kurlianskaya
Published: February 2022

Aim. To develop a multifactor response prediction model to CRT in patients with CHF complicated by AF taking into consideration myocardium dyssinchrony parameters, clinical, functional, and laboratory predictors of a positive response to interventional treatment. Methods. The article is devoted to the evaluation of cardiac resynchroniza- tion therapy (CRT) clinical results in patients with chronic heart failure (CHF) and persistent atrial fibrillation (AF) within 12 months after interventional treatment. The paper presents multifactor CRT response prediction models taking into consideration electrical and mechanical myocardium dyssinchrony parameters, as well as clinical, functional, and laboratory positive response predictors. Results. CRT results in patients with CHF complicated by AF showed variable patterns dependent on time and persistence of the treatment outcome: long-term outcome retention in a three-month period (39%); “escape” from CRT early outcome (9%); delayed echocardiographic response to CRT (in 12 months); no response to CRT (21%). Early response to CRT predictor complex (during the first 3 months) in patients with CHF and AF mainly includes myocardial dyssinchrony parameters (QR complex width, presystolic aortic valve delay, pulmonary artery valve delay, interventricular delay, dyssinchrony index), as well as CHF severity criteria (CHF FC, NT-proBNP concentration) and myocardial deformity in the apical projection. The most significant contribution to the prediction of the long-term effectiveness of CRT in patients with CHF and AF is made by parameters reflecting the severity of interventricular and intraventricular cardiac dyssinchrony: presystolic delay on the aortic valve and dispersion of intraventricular contraction. Additional prognostic criteria for the CRT response are lower values of myocardial deformity in the apical projection and GFR. Conclusion. The linear model developed to assess the dynamics of LV ESV allows individualizing the patient selection for interventional treatment in case of predicting an unstable early response to CRT.
ECHOGRAPHIC SIGNS OF PULMONARY OUTCOMES IN PATIENTS AFTER CORONAVIRUS INFECTION (SARS-CoV2) AND DIFFICULTIES OF THEIR INTERPRETATION
Authors:   Belarusian Medical Academy of Post-Graduate Education, N.V. Klimovich , L.V. Sivachenco ,   Minsk City Clinical Hospital of Infectious Diseases, O.M. Zherco ,   Belarusian Medical Academy of Post-Graduate Education, Y.L. Gorbich ,   Belarusian Medical Academy of Post-Graduate Education, O.Ch. Glaz ,   Minsk City Clinical Hospital of Infectious Diseases
Published: February 2022

A numberof respiratory infections can result in pulmonary fibrosis as anoutcome. SARS-CoV2, along with other coronaviruses, is no exception. The factors contributing to the formation of fibrosis are insufficiently studied. Nor are the methods for determining the activity of the process and the degree of fibrosis in the lung are well developed. Among the instrumental methods, along with computed tomography of the chest, an alternative option for dynamic monitoring can be the method of ultrasound examination of the lungs. Among laboratory parameters, C-reactive protein and fibrinogen are of interest.
CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression
Authors: Zhao Junyin , Shen Jincheng , Wang Zeying , Bai Man , Fan Yixing , Zhu Yubo , Bai Wenlin
Published: February 2022

Abstract. Circular RNAs (circRNAs) have stable structures,
being a covalently closed loop without 5′ and 3′ free ends.
They can function as “miRNA sponges” in regulating the expression of their
target genes. It was thought that circRNAs are involved in the development
of the secondary hair follicle (SHF) in cashmere goats. In our previous
investigation, a new circRNA named circRNA-0100 was identified from the
SHF of cashmere goats, but its function is unknown. In this work, we found
that circRNA-0100 exhibited significantly higher expression at anagen SHF
bulge than its counterpart at telogen in cashmere goats. Based on the use of
both overexpression and siRNA interference assays, our data indicated that
circRNA-0100 promoted the differentiation of cashmere goat SHF stem cells
(SHF-SCs) into hair follicle lineage, which was evaluated by analyzing the
transcriptional level changes of six indicator genes in SHF-SCs of cashmere
goats. Using the RNA pull-down technique, we showed that
circRNA-0100 served as “molecular sponges” of miR-153-3p in SHF-SCs.
Through the use of dual-luciferase reporter assays, our data indicated that
circRNA-0100 positively regulated the transcriptional expression of the KLF5
gene via the miR-153-3p-mediated pathway. Ultimately, we showed that
circRNA-0100 promoted the differentiation of SHF-SCs into hair lineage, which
might be achieved via sequestering miR-153-3p to heighten the KLF5
expression in SHF-SCs of cashmere goats. Our results provide novel
scientific evidence for revealing the potential molecular regulatory
mechanisms on the differentiation of SHF-SCs into hair lineage in cashmere
goats.
Digestibility and palatability of Virginia fanpetals (Sida hermaphrodita R.) silage in sheep
Authors: Purwin Cezary , Borsuk-Stanulewicz Marta , Nogalski Zenon , Baranowska Maja , Zygmuntowicz Aleksandra , Michalski Jacek P.
Published: February 2022

Abstract. The aim of the current study is to evaluate Virginia
fanpetals silage based on an apparent digestibility and palatability test performed on six adult rams. Alfalfa silage was used as standard
forage for comparison. Virginia fanpetals samples were harvested in the bud-formation
stage and alfalfa samples were harvested in the late bud stage. Virginia fanpetals
silage had a crude protein (CP) content of 176 g kg−1 dry matter (DM), a neutral
detergent fiber (NDF) content of 378 g kg−1 DM, and a lignin content of 42.8 g kg−1 DM. Virginia fanpetals silage had higher acidity (pH of 4.30) and was
characterized by intense lactic acid fermentation compared with alfalfa
silage (80 % vs. 51 % of the total acids). The digestibility coefficient
of Virginia fanpetals silage was as follows: for DM it was 0.707, for organic matter (OM)
it was 0.724, for CP it was 0.861, and for NDF it was 0.609. In comparison with alfalfa silage,
Virginia fanpetals silage was characterized by higher apparent digestibility
of nutrients, but a significant difference was noted only for CP. The
voluntary intake of Virginia fanpetals silage was significantly higher than
that of alfalfa silage (1427.4 vs. 954 g DM). The greatest differences in
voluntary intake were observed 0–2 and 8–12 h after feeding. Virginia
fanpetals silage had a chemical composition similar to that of alfalfa, but
it was characterized by a more desirable fermentation pattern and higher
digestibility, and it was more willingly consumed by rams. The present
findings indicate that Virginia fanpetals silage can be fed to sheep.
Cloud microphysical measurements at a mountain observatory: comparison between shadowgraph imaging and phase Doppler interferometry
Authors: Mohammadi Moein , Nowak Jakub L. , Bertens Guus , Moláček Jan , Kumala Wojciech , Malinowski Szymon P.
Published: February 2022

Abstract. The microphysical properties of cloud droplets, such as droplet size distribution and droplet number concentration, were studied. A series of field
experiments was performed in the summer of 2019 at the Umweltforschungsstation Schneefernerhaus (UFS), an environmental research station located
just below the peak of the Zugspitze mountain in the German Alps. A VisiSize D30 manufactured by Oxford Laser Ltd., which is a shadowgraph imaging
instrument, was utilized for the first time to measure the size and velocity of cloud droplets during this campaign. Furthermore, a phase Doppler
interferometer (PDI) device, manufactured by Artium Tech. Inc., was simultaneously measuring cloud droplets. After applying modifications to the
built-in software algorithms, the results from the two instruments show reasonable agreement regarding droplet sizing and velocimetry for droplet
diameters larger than 13 µm. Moreover, discrepancies were observed concerning the droplet number concentration results, especially with
smaller droplet sizes. Further investigation by applying appropriate filters to the data allowed the attribution of the discrepancies to two
phenomena: the different optical performance of the sensors with regard to small droplets and high turbulent velocity fluctuations relative to the
mean flow that result in an uncertain estimate of the volume of air passing through the PDI probe volume.
Comparison of GRUAN Data Products for Meisei iMS-100 and Vaisala RS92 Radiosondes at Tateno, Japan
Authors: Hoshino Shunsuke , Sugidachi Takuji , Shimizu Kensaku , Kobayashi Eriko , Fujiwara Masatomo , Iwabuchi Masami
Published: February 2022

Abstract. A total of 99 dual soundings with Meisei iMS-100 radiosonde and Vaisala RS92 radiosondes were carried out at Aerological Observatory of the Japan Meteorological Agency, known as Tateno (36.06° N, 140.13° E, 25.2 m; WMO station number 47646), from September 2017 to January 2020. Global Climate Observing System (GCOS) Reference Upper-Air Network (GRUAN) data products (GDP) from both sets of radiosonde data for 57 flights were subsequently created using a documented processing program along with the provision of optimal estimates for measurement uncertainty. Differences in radiosonde performance were then quantified using these GDPs. For daytime observations, the iMS-100 temperature is around 0.5 K lower than RS92-GDP in the stratosphere with significant differences in the upper troposphere and lower stratosphere with RS92-GDP in consideration of combined uncertainties. For nighttime observations, the difference is around −0.1 K and data are mostly in agreement. For relative humidity (RH), iMS-100 is around 1–2 %RH higher in the troposphere and 1 %RH smaller in the stratosphere than RS92, but both GDPs are in agreement for most of the profile. The mean pressure difference is ≤ 0.1 hPa, the wind speed difference is from 0.15 m s−1 to 0.01 m s−1, the wind direction difference ≤ 5°, and the root mean square of vector difference (RMSVD) for wind is ≤ 0.72 m s−1.
Benthic Silicon Cycling in the Arctic Barents Sea: a Reaction-Transport Model Study
Authors: Ward James P. J. , Hendry Katherine R. , Arndt Sandra , Faust Johan C. , Freitas Felipe S. , Henley Sian F. , Krause Jeffrey W. , März Christian , Tessin Allyson C. , Airs Ruth L.
Published: February 2022

Abstract. Over recent decades the highest rates of water column warming and sea ice loss across the Arctic Ocean have been observed in the Barents Sea. These physical changes have resulted in rapid ecosystem adjustments, manifesting as a northward migration of temperate phytoplankton species at the expense of silica-based diatoms. These changes will potentially alter the composition of phytodetritus deposited at the seafloor, which acts as a biogeochemical reactor, pivotal in the recycling of key nutrients, such as silicon (Si). To appreciate the sensitivity of the Barents Sea benthic system to the observed changes in surface primary production, there is a need to better understand this benthic-pelagic coupling. Stable Si isotopic compositions of sediment pore waters and the solid phase from three stations in the Barents Sea reveal a coupling of the iron (Fe) and Si cycles, the contemporaneous dissolution of lithogenic silicate minerals (LSi) alongside biogenic silica (BSi) and the potential for the reprecipitation of dissolved silicic acid (DSi) as authigenic clay minerals (AuSi). However, as reaction rates cannot be quantified from observational data alone, a mechanistic understanding of which factors control these processes is missing. Here, we employ reaction-transport modelling together with observational data to disentangle the reaction pathways controlling the cycling of Si within the seafloor. Processes such as the dissolution of BSi are active on multiple timescales, ranging from weeks to hundreds of years, which we are able to examine through steady state and transient model runs. Steady state simulations show that 60 to 98 % of the sediment pore water DSi pool may be sourced from the dissolution of LSi, while the isotopic composition is also strongly influenced by the desorption of Si from metal oxides, most likely Fe (oxyhydr)oxides (FeSi), as they reductively dissolve. Further, our model simulations indicate that between 2.9 and 37 % of the DSi released into sediment pore waters is taken up with a fractionation factor of approximately −2 ‰, most likely representing reprecipitation as AuSi. These observations are significant, as the dissolution of LSi represents a source of new Si to the ocean DSi pool and precipitation of AuSi an additional sink, which could address imbalances in the current regional ocean Si budget. Lastly, transient modelling suggests that at least one-third of the total annual benthic DSi flux could be sourced from the dissolution of more reactive, diatom-derived BSi deposited after the surface water bloom at the marginal ice zone. This benthic-pelagic coupling will be subject to change with the continued northward migration of Atlantic phytoplankton species, northward retreat of the marginal ice zone and the observed decline in DSi inventory of the subpolar North Atlantic Ocean over the last three decades.
Deep-learning spatial principles from deterministic chemical transport models for chemical reanalysis: an application in China for PM2.5
Authors: Lyu Baolei , Huang Ran , Wang Xinlu , Wang Weiguo , Hu Yongtao
Published: February 2022

Abstract. Well-estimated air pollutant concentration fields are
critically important to compensate for observations that are only sparsely
available, especially over non-urban areas. Previous data fusion methods
generally used statistical models to relate observations of target variables
to proxy data and supporting variables at known stations. In this study,
we developed a new data fusion paradigm by designing a deep-learning model
framework and workflow to learn multivariable spatial correlations from
chemical transport model (CTM) simulations, before using it to estimate
PM2.5 reanalysis fields from station observations. The model was
composed of two modules as an explainable PointConv operation to pre-process
isolated observations and a regression grid-to-grid network to build
correlations among multiple variables. The model was trained with only CTM
simulations and supporting geographical covariates. The trained model was
evaluated in two aspects of (1) reproducing raw PM2.5 CTM simulations
and (2) generating reanalysis and fused PM2.5 fields. First, the model was
able to reproduce the CTM simulations well on a full domain from sampled CTM
data items at sparse locations with an average R2=0.94 and
RMSE = 4.85 µg m−3. Second, the fused PM2.5 fields estimated
from observations achieved a good performance with R2=0.77
(RMSE = 14.29 µg m−3) and R2=0.84 (RMSE = 12.96 µg m−3) respectively evaluated at the stringent city level and
station level. The generated reanalysis PM2.5 fields have complete
spatial coverage within the modeling domain. One significant benefit of the
fusion framework is that the model training does not rely on observations,
which can be used to predict PM2.5 fields in newly set up observation
networks such as those using portable sensors. Meanwhile, in the prediction
procedure, only station observations are used along with supporting
covariates. The fusion model has high computing efficiency (< 1 s d−1) due to acceleration using a graphical processing unit (GPU). As an alternative to generate
chemical reanalysis fields, the method can be readily implemented in near-real time and be universally applied for other simulated variables with
measurements available.
Localising nuclear spins by pseudocontact shifts from a single tagging site
Authors: Orton Henry W. , Abdelkader Elwy H. , Topping Lydia , Butler Stephen J. , Otting Gottfried
Published: February 2022

Abstract. Ligating a protein at a specific site with a tag molecule containing a paramagnetic metal ion provides a versatile way of generating pseudocontact shifts (PCS) in nuclear magnetic resonance (NMR) spectra. PCSs can be observed for nuclear spins far from the tagging site and PCSs generated from multiple tagging sites have been shown to enable highly accurate structure determinations. The present work investigates the situation, where only the local structure of a protein region or bound ligand is to be determined rather than the structure of the entire molecular system. In this case, the need for gathering structural information from tags deployed at multiple sites may be queried. Our study presents a computational simulation of the structural information available from samples produced with single tags attached at up to six different sites, up to six different tags attached to a single site, as well as scenarios in-between. The results indicate that the number of tags is much more important than the number of tagging sites. This has important practical implications, as it is much easier to identify a single site that is suitable for tagging than multiple ones. In an initial experimental demonstration with the ubiquitin mutant S57C, PCSs generated with four different tags at a single site are shown to accurately pinpoint the location of amide protons in different segments of the protein.
Microstructure, micro-inclusions, and mineralogy along the EGRIP (East Greenland Ice Core Project) ice core – Part 2: Implications for palaeo-mineralogy
Authors: Stoll Nicolas , Hörhold Maria , Erhardt Tobias , Eichler Jan , Jensen Camilla , Weikusat Ilka
Published: February 2022

Abstract. Impurities in polar ice do not only allow the reconstruction of past atmospheric aerosol concentrations but also influence the physical properties of the ice. However, the localisation of impurities inside the microstructure is still under debate and little is known about the mineralogy of solid inclusions. In particular, the general mineralogical diversity throughout an ice core and the specific distribution inside the microstructure is poorly investigated; the impact of the mineralogy on the localisation of inclusions and other processes is thus hardly known. We use dust particle concentration, optical microscopy, and cryo-Raman spectroscopy to systematically locate and analyse the mineralogy of micro-inclusions in situ inside 11 solid ice samples from the upper 1340 m of the East Greenland Ice Core Project ice core. Micro-inclusions are more variable in mineralogy than previously observed and are mainly composed of mineral dust (quartz, mica, and feldspar) and sulfates (mainly gypsum). Inclusions of the same composition tend to cluster, but clustering frequency and mineralogy changes with depth. A variety of sulfates dominate the upper 900 m, while gypsum is the only sulfate in deeper samples, which however contain more mineral dust, nitrates, and dolomite. The analysed part of the core can thus be divided into two depth regimes of different mineralogy, and to a lesser degree of spatial distribution, which could originate from different chemical reactions in the ice or large-scale changes in ice cover in northeast Greenland during the mid-Holocene. The complexity of impurity mineralogy on the metre scale and centimetre scale in polar ice is still underestimated, and new methodological approaches are necessary to establish a comprehensive understanding of the role of impurities. Our results show that applying new methods to the mineralogy in ice cores and recognising its complexity, as well as the importance for localisation studies, open new avenues for understanding the role of impurities in ice cores.
Peace Sociolinguistics: A Constructivist Grounded Theory of Pakistani English Newspapers
Authors: Zaidii Shehr Bano
Published: February 2022

This paper is a qualitative sociolinguistic study that theorizes the place of English as an official/second language in Pakistan. The data are taken from six Pakistani English newspapers covering the Pak-EU discourse from 2002 to 2018. This investigation uses constructivist grounded theory methodology (an off-shoot of grounded theory methodology) to generate a theory that shedslight on the peace potential of English language as used in the selected data. It is subsumed under the parameters of peace sociolinguistics, a relatively new field within the broader discipline of sociolinguistics. Peace sociolinguistics acknowledges all languages to be carriers of human values and capable of bringing different peoples together. In the classic style of grounded theorymethodology, primacy is given to language and codes are developed in order to show how English language is used to portray a common reality between two world entities, Pakistan and the EU. This sociolinguistic constructivist grounded theory study is underpinned by social constructionism which takes the view that language does not just describe the world but actively constructsit, having real consequences. The socially constructed reality presented here is shared and contextual and takes the form of a rigorous theory called “a theory of peace sociolinguistics of the EU-Pak discourse in selected Pakistani English newspapers.'' This theoretical rendering demonstrates the viability of English to be used for peaceful purposes while challenging the current dual status ofEnglish as a colonial legacy and a necessary agent of globalization.
A Corpus-based Study of Interdisciplinary Variation of Metadiscourse in Pakistani Research Papers of Soft Sciences
Authors: Abbas Akhtar , Shehzad Waseema
Published: February 2022

Metadiscourse is a recent enterprise of applied linguists through which the text-internalnature of discourse is explored with reference to persuasion, negotiation, and engagement of the writers with their own discourses and the readers too (Hyland, 2005). Metadiscourse, with respect to genre, register, and cultural situatedness,has been the major foci of inquiries till now. However, patterns of interaction situatedamong differentdiscourse communities of academics through metadiscourse need more attention in general and, in Pakistani context, in particular. Therefore, the current study intends to investigate interactiveand interactional metadiscourse in Pakistani research discourses of English, Education, and History. For this purpose, we collected 52 research articles comprising corpus of 231529words published in research journals recognized by Higher Education Commission, Pakistan. We applied Hyland’s framework of metadiscoursefor mapping expressions as metadiscursive. For identification of 300 metadiscursive markers proposed by Hyland, a recent corpus tool named MetaPak (Abbas et al. 201b) was used successfully. The study revealed noticeable variation in occurrenceand prototypicalityof metadiscourse employment in Pakistani research discourses while comparing with other international studies. This variation, consequently, may be considered one of the important factors causing dialogic closurein order to achieve persuasion, negotiation, and engagement of the international gate keepers, reviewers, and readers.
Cantinflear para politizar. Chiste, orden médico y propaganda política en 'El señor doctor' de Cantinfas
Authors: Zamora Echegollen Mayleth Alejandra , Juárez-Salazar Edgar Miguel
Published: February 2022

El presente artículo busca problamtizar la película El señor doctor protagonizada por el cómico mexicano Mario Moreno “Cantinflas”. A partir de una lectura desde la llamada Escuela Eslovena, proponemos una revisión de las condiciones políticas, sociales y médicas que se ven reflejadas en la película. Asi, nuestro recorrido busca clarificar algunas aproximaciones a la relación política de Cantinflas con la clase política de los años sesenta en México y el uso de sus películas, como elemento más allá de la propaganda para poder, establecer dinámicas de apoyo y validación del régimen del Partido Revolucionario Institucional (PRI) en México. Paralelamente hacemos un análisis de las estructuras discursivas, médico-políticas, en las cuales buscamos fundamentar la influencia de los discursos de Cantinflas que validaban la dinámica institucional del PRI en la propuesta del Estado.
Estrategias de comunicación, educativas y vitales: ¿resistencia numantina?
Authors: Revuelta Bayod María José
Published: February 2022

La profesión académica, docente e investigadora, está repleta de interacciones con profesionales que adoptas como ejemplo en circunstancias que casi pasan desapercibidas en el momento. Pasado el tiempo, haciendo una retrospectiva, visualizas los acontecimientos que te marcaron, como una interacción recíproca entre el sustento racional que requiere esta profesión y las inevitables y a veces enigmáticas emociones. Porque el camino de la ciencia nunca estuvo exento de ellas.
El impacto del uso de herramientas automáticas de ayuda a la redacción en el proceso de escritura de estudiantes universitarios
Authors: Nuñez Cortés Juan Antonio , Da Cunha Fanego Iria
Published: February 2022

Las iniciativas de alfabetización académica se centran en la didáctica de los géneros discursivos académicos y de las fases del proceso de escritura. En este contexto, el objetivo del trabajo es determinar el impacto de las recomendaciones ofrecidas por un sistema automático de ayuda a la redacción, arText, en la revisión de los textos por parte de estudiantes universitarios. Para ello, se analizan cualitativa y cuantitativamente las recomendaciones propuestas y las aplicadas por los estudiantes en 117 textos, así como sus valoraciones a las recomendaciones. Los resultados indican que se aplican más de la mitad de las recomendaciones, siendo las más frecuentes las relacionadas con la longitud oracional y los conectores discursivos, mientras que las menos productivas son las relativas a formas verbales y marcas de subjetividad. La principal conclusión del estudio es que las herramientas tecnológicas de ayuda a la redacción constituyen un apoyo para el desarrollo de la expresión escrita en la universidad.
Pensar la persona a través del tejido: una propuesta de interpretación a partir del ejemplo de los tejidos jalq’a (Bolivia)
Authors: Raas Kimberley
Published: February 2022

Este texto tiene como objetivo presentar una propuesta para explorar de qué maneras se puede considerar que se identifica, presenta y constituye la persona, en términos sociales y ontológicos, a través del tejido en los Andes. Partiendo de la vestimenta tradicional jalq’a (Andes bolivianos) y su particular estilo de decoración tejida como ejemplo, propongo tres enfoques para contribuir a esta reflexión: presentando la vestimenta tradicional como distintivo étnico, prestando atención a las relaciones que se generan en torno a la elaboración del tejido, y considerando el uso de los tejidos como ropas que envuelven el cuerpo para formar a la persona como runa.
Mujtahid Scholars in Islamic Law
Authors: Demir Abdullah , Adamu Mohammed Hilal
Published: February 2022

The mujtahid scholars period is about two centuries from the early days of the Abbasids until the time of the Karahanlılar. One of the features of this period is the codification of Islamic law and the establishment of sects. Major jurists who perform the codification activity are: Sufyan b. Uyeyne (Mecca), Malik b. Enes (Medina), Hasan Basri (Basra), Abu Hanifa, Sufyan-iSevri (Kufe), Evzai (Sham), Shafii, Leys b. Sa’d (Egypt), Isaac b. Rahuveyh (Nisabur), Ahmed b. Hanbal, Davud-u Zahiri and Ibn Cerir (Baghdad). Some of these sects still exist today. Since some of them are not members of the group, theoretically their views are found in the books. Keywords: mujtahid scholars, Islamic law, Sufyan b. Uyeyne, Malik b. Enes, Hasan Basri, Abu Hanifa, Sufyan-iSevri, Evzai, Shafii, Leys b. Sa’d, Isaac b. Rahuveyh, Ahmed b. Hanbal, Davud-u Zahiri and Ibn Cerir
Perakendeci Bakış Açısı ile Omnichannel Yaklaşımı ve Tüketici: Bir Mobil Cihazlar Firması Örneği
Authors: ÖZKAYA Berkay , VENTURA Keti
Published: February 2022

The present study aims to explore the perspectives and adaptation levels of mobile device retailers towards omnichannel and to determine the benefits offered by the approach for the customers. The study adopts a explorative method, using qualitative research methods and semi-structured interview technique. This method has been used to unravel the benefits for the customer in mobile device market in a explorative approach. In this respect, we aimed to interview representatives with a certain degree of awareness about omnichannel and mobile devices from a smart phone manufacturer based in Turkey using purposive sampling method. As a result, interviews have been made with 4 people from the department of Smart Phone, Mobile and IOT Devices Marketing and Product Manager, E-Commerce Specialist and Retail Marketing and Customer Experience Development. The fact that the interviews have been made with people selected by purposive sampling method, included only one firm and thus has excluded a significant portion of the sampling, are the limitations of the study. Results reveal that the primary benefit of mobile devices is increasing the interaction between the customers of all other markets in terms of omnichannel integration. Furthermore, various factors such as customer-oriented behavior of firms, time, space and decreasing risk offer benefits for the customers. On the other hand, the fact that omnichannel infrastructure is not still well established causes a problem: the customers cannot be perceived as a single customer in each channel. It has been observed that omnichannel infrastructure has to be improved to maximize the benefits for the customers and firms, which will in turn, provide a win-win situation. Jel Codes: L81, M31, M10 Keywords: Omnichannel, retail, mobile devices, e-commerce, consumer
IBADAH SEBAGAI GAYA HIDUP MENURUT ROMA 12:1 DAN IMPLIKASINYA BAGI IBADAH MASA KINI
Authors: Takaliuang Jammes Juneidy
Published: February 2022

Ibadah yang sejati bukan hanya didasarkan pada pengalaman tetapi didasarkan pada sebuah pemahaman teologis yang mendasar. Artinya ibadah harus di dasarkan pada Alkitab yang adalah Firman Allah. Maka kebenaran dari ibadah bersifat mutlak dan harus dilakukan. Jika ibadah didasarkan kepada pengalaman pribadi, maka kebenaran dari ibadah tersebut tergantung apa kata pribadi sehingga nilai kebenarannya adalah relatif, manusia sebagai penentu kebenaran. Jika kebenaran ibadah adalah relatif, maka ibadah dapat ditolak yang berarti perlawanan terhadap Allah. Ibadah yang didasarkan pada pengalaman semakin jelas tujuannya yaitu ibadah antropocentris. Karena itu, ibadah harus dikaji secara teologis dengan melihat beberapa aspek penting yang saling berkaitan satu dengan yang lain dan berfondasi pada Alkitab. Jika hal ini dilakukan, maka dipastikan bahwa ibadah tersebut adalah ibadah yang sehat karena memberi gizi yang tepat bagi orang-orang yang melaksanakan ibadah.
JATI DIRI PEREMPUAN MENURUT KEJADIAN 1-2 DAN RELEVANSINYA BAGI SIKAP KRISTIANI TERHADAP PENGARUH GERAKAN FEMINISME DI INDONESIA
Authors: Endojowatiningsih Maria Hanie
Published: February 2022

Gerakan Feminisme lahir dari kerinduan para perempuan ingin keluar dari kungkungan atau tekanan budaya patriarkhat yang cenderung merendahkan dan merugikan kaum perempuan. Dan gerakan Feminisme ini juga berpengaruh dalam Theologia, sehingga melahirkan Theologia Feminisme, yang melahirkan juga pola-pola penafsiran Alkitab, yang menguntungkan kaum perempuan. Gerakan Feminisme di Indonesia bisa memotivasi kaum perempuan untuk mendapatkan hak-haknya. Namun gerakan ini tidak mampu secara tuntas meniadakan budaya patriarkhat yang sudah mendarah-daging di masyarakat Indonesia. Untuk itu, kaum perempuan, terma suk perempuan Kristen tidak bisa memaksakan haknya. Di kalangan Gereja, tentunya bukan karena adanya Gerakan Feminisme barulah orang Kristen memberi penghargaan kepada kaum perempuan secara proporsional, melainkan berdasarkan Firman Tuhan sendiri, khususnya dalam Kitab Kejadian pasal 1-2, di mana perempuan diciptakan Tuhan sejajar dengan laki-laki, yakni menurut gambar atau rupa Allah sendiri, dengan tugas yang sama dalam melaksanakan Amanat Budaya, meskipun peran konkritnya berbeda. Dalam relasinya dengan laki-laki/suami, perempuan bertugas sebagai penolong/ pendukung. Ini satu tugas yang istimewa. Dan bahwa perempuan diciptakan untuk dikasihi dan dilindungi, karena dari satu tulang rusuk yang berasal dari laki-laki.
USIA EMAS (‘GOLDEN-AGE’): MENYOAL KEPEDULIAN ORANGTUA TERHADAP PAUD (Menyambut ‘Kehadiran’ FKIP Prodi: PAUD di I-3, Batu, Jawa Timur)
Authors: Adipati Yustus
Published: February 2022

Berdasarkan berbagai penjelasan berkenan dengan kepedulian orangtua terhadap  PAUD, maka beberapa faktor disebutkan sebagai berikut: Fakfor ‘Skill Anak’: Memberikan perhatian seperti sarana penunjang bagi kesehatan fisik anak; pemenuhan kebutuhan gizi anak melalui makan dan minuman yang sehat, serta kebutuhan vitamin, sampai kepada pemenuhan kebutuhan asupan-asupan penunjang lainnya; Faktor Pola Belajar Anak: Memberikan perhatian berupa kebutuhan fasilitas sarana prasarana belajar, seperti alat bermain anak untuk membangun antusiasme serta rasa keingin-tahuan anak, dengan berkesinambungan, konsistensi, keteraturan agar pembiasaan belajar itu menjadi ‘Daily Habit’; Faktor Respon Anak dalam Mengatasi Konflik: Memberikan pengalaman mencurahkan isi hati anak kepada orangtua; menempatkan diri di tengah persaingan, serta mempelajari pelbagai aturan atau norma yang berlaku. Melalui penjelasan di atas, dapat dirangkum beberapa indikator mengenai Kepedulian orangtua terhadap PAUD, sebagai berikut: (1) Faktor ‘Skill Anak’, dengan indikator-indikatornya, meliputi: a) Kesehatan Fisik, b) Kebutuhan Gizi; (2) Faktor Pola Belajar Anak, dengan indikator-indikatornya, meliputi: a) Fasilitas Belajar, b)  Fasilitas bermain, c)  Kebiasaan belajar; (3) Faktor Respon Anak dalam Mengatasi Konflik, dengan indikator-indikatornya, meliputi: a) Pencurahan hati, b) Persainan, c) aturan.