bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying Potential Mitochondrial Proteome Signatures Associated with the Pathogenesis of Pulmonary Arterial Hypertension in the Rat Model
Authors: Wang Jie , Uddin Md. Nazim , Li Qian , Aierken Alidan , Li Ming-Yuan , Wang Rui , Yan Qian-zhi , Adi Dilare , Gai Ming-Tao , Wu Yun
Published: February 2022

Pulmonary arterial hypertension (PAH) is a severe and progressive disease that affects the heart and lungs and a global health concern that impacts individuals and society. Studies have reported that some proteins related to mitochondrial metabolic functions could play an essential role in the pathogenesis of PAH, and their specific expression and biological function are still unclear. We successfully constructed a monocrotaline- (MCT-) induced PAH rat model in the present research. Then, the label-free quantification proteomic technique was used to determine mitochondrial proteins between the PAH group (

n
=
6

) and the normal group (

n
=
6

). Besides, we identified 1346 mitochondrial differentially expressed proteins (DEPs) between these two groups. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the mainly mitochondrial DEPs’ biological functions and the signal pathways. Based on the protein-protein interaction (PPI) network construction and functional enrichment, we screened 19 upregulated mitochondrial genes (Psmd1, Psmc4, Psmd13, Psmc2, etc.) and 123 downregulated mitochondrial genes (Uqcrfs1, Uqcrc1, Atp5c1, Atp5a1, Uqcrc2, etc.) in rats with PAH. Furthermore, in an independent cohort dataset and experiments with rat lung tissue using qPCR, validation results consistently showed that 6 upregulated mitochondrial genes (Psmd2, Psmc4, Psmc3, Psmc5, Psmd13, and Psmc2) and 3 downregulated mitochondrial genes (Lipe, Cat, and Prkce) were significantly differentially expressed in the lung tissue of PAH rats. Using the RNAInter database, we predict potential miRNA target hub mitochondrial genes at the transcriptome level. We also identified bortezomib and carfilzomib as the potential drugs for treatment in PAH. Finally, this study provides us with a new perspective on critical biomarkers and treatment strategies in PAH.
Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome
Authors: Torres-Jacome Julian , Ortiz-Fuentes Brian Sabino , Bernabe-Sanchez Daniela , Lopez-Silva Benjamin , Velasco Myrian , Ita-Amador Martha Lucia , Albarado-Ibañez Alondra
Published: February 2022

Obesity and dyslipidemias are both signs of metabolic syndrome, usually associated with ventricular arrhythmias. Here, we tried to identify cardiac electrical alteration and biomarkers in nonobese rats with metabolic syndrome (MetS), and these findings might lead to more lethal arrhythmias than obese animals. The MetS model was developed in Wistar rats with high-sucrose diet (20%), and after twenty-eight weeks were obtained two subgroups: obese (OMetS) and nonobese (NOMetS). The electrocardiogram was used to measure the ventricular arrhythmias and changes in the heart rate variability. Also, we measured ventricular hypertrophy and its relationship with electrical activity alterations of both ventricles, using micro-electrode and voltage clamp techniques. Also, we observed alterations in the contraction force of ventricles where a transducer was used to record mechanical and electrical papillary muscle, simultaneously. Despite both subgroups presenting long QT syndrome (

0.66
±
0.05

and

0.66
±
0.07

 ms with respect to the

control
 
0.55
±
0.1

 ms), the changes in the heart rate variability were present only in OMetS, while the NOMetS subgroup presented changes in QT interval variability (NOMetS

SD
=
1.8

,

SD
2
=
2.8

;

SD
1
/
SD
2
=
0.75

). Also, the NOMetS revealed tachycardia (10%;

p
<
0.05

) with changes in action potential duration (63% in the right papillary and 50% in the left papillary) in the ventricular papillary which are correlated with certain alterations in the potassium currents and the force of contraction. The OMetS showed an increase in action potential duration and the force of contraction in both ventricles, which are explained as bradycardia. Our results revealed lethal arrhythmias in both MetS subgroups, irrespectively of the presence of obesity. Consequently, the NOMetS showed mechanical-electrical alterations regarding ventricle hypertrophy that should be at the NOMetS, leading to an increase of CV mortality.
Operational Scheduling of Behind-the-Meter Storage Systems Based on Multiple Nonstationary Decomposition and Deep Convolutional Neural Network for Price Forecasting
Authors: Deng Zhuofu , Qi Xianglong , Xu Tengteng , Zheng Yingnan
Published: February 2022

In the competitive electricity market, electricity price reflects the relationship between power supply and demand and plays an important role in the strategic behavior of market players. With the development of energy storage systems after watt-hour meter, accurate price prediction becomes more and more crucial in the energy management and control of energy storage systems. Due to the great uncertainty of electricity price, the performance of the general electricity price forecasting models is not satisfactory to be adopted in practice. Therefore, in this paper, we propose a novel electricity price forecasting strategy applied in optimization for the scheduling of battery energy storage systems. At first, multiple nonstationary decompositions are presented to extract the most significant components in price series, which express remarkably discriminative features in price fluctuation for regression prediction. In addition, all extracted components are delivered to a devised deep convolution neural network with multiscale dilated kernels for multistep price forecasting. At last, more advanced price fluctuation detection serves the optimized operation of the battery energy storage system within Ontario grid-connected microgrids. Sufficient ablation studies showed that our proposed price forecasting strategy provides predominant performances compared with the state-of-the-art methods and implies a promising prospect in economic benefits of battery energy storage systems.
Design and Research of Physical Education Platform Based on Artificial Intelligence
Authors: Ba Yufeng , Liu Zhenfeng
Published: February 2022

With the continuous development of information technology, conventional physical education teaching methods are no longer applicable. In order to ensure the objectivity of college physical education evaluation, this paper designs a set of college physical education management information system based on artificial intelligence technology. The weighting algorithm in the student performance evaluation module and teacher performance evaluation module in the system adopts the intelligent algorithm based on FNN neural network. Experimental verification shows that the intelligent algorithm based on the FNN neural network can effectively predict the students’ score in the national college physical education examination, which can provide a more objective basis for teacher performance evaluation.
The Influence of Repeated Drop Jump Training on Countermovement Jump Performance
Authors: He Lin , Li Yu-Ge , Wu Chou , Yao Shun , Su Yu , Ma Guo-Dong , Wang I-Lin
Published: February 2022

Countermovement jump (CMJ) is used to assess athletic performance of the lower limbs. Drop jump (DJ) is an effect training method that can improve athlete’s jumping performance. The main purpose of this study is to explore the effects of different drop jump heights (DJH)30, DJH40, and DJH50 cm for 250 drop jumps (DJs250) on CMJ. Eighteen male athletes were selected as subjects. After the 50th, 100th, 150th, 200th, and 250th DJs, perform 5 groups of CMJ (the average of 3 times for each group) and record them as the 50th, 100th, 150th, 200th, and 250th CMJ jumps (CMJs50, CMJs100, CMJs150, CMJs200, and CMJs250). The BTS motion capture system and two force plates are used to record data. The MATLAB software was used to analyze data through one-way ANOVA repeated measures. If there is a significant difference, the LSD method is used for post hoc comparison. Jump height (JH), contact time (CT), reaction intensity index (RSI), average rate of force development (ARFD), left average rate of force development (LARFD), and right average rate of force development (RARFD) of CMJs50, CMJs100, CMJs150, and CMJs200 at DJH50 were greater than those at DJH40 and DJH30 (all

p
<
0.05

). DJH50 height and DJs200 training times can improve SSC mechanism and improve athlete CMJ performance.
Genetic Landscape of SCN1A Variants in a Turkish Cohort with GEFS+ Spectrum and Dravet Syndrome
Authors: Türkyılmaz Ayberk , Tekin Emine , Yaralı Oğuzhan , Çebi Alper Han
Published: February 2022

Introduction: The α subunit of voltage-gated sodium channels in mammals is encoded by 9 different genes, and variations in the SCN1A, SCN2A, SCN3A, and SCN8A genes highly expressed in the CNS have been associated with epilepsy phenotypes. This study aimed at investigating the frequency of SCN1A gene variations in Dravet syndrome (DS) and GEFS+ spectrum phenotype cases and discussing the molecular results in the context of genotype-phenotype correlation. Methods: Fifteen patients diagnosed with DS and 54 patients meeting the GEFS+ spectrum criteria were included in this study. All patients were evaluated by next-generation sequencing and multiplex ligation-dependent probe amplification using an SCN1A gene commercial kit. Results: A total of 17 different variants were detected in 18 index cases (26%), of which 7 were novel variations (p.M1R, p.M147T, p.I767L, p.N1391Ifs*5, p.R1886G, p.E1915G, p.R1933Q). Of the 18 cases with variation in the SCN1A gene, 12 had DS and 6 had GEFS+ phenotype. The variations were de novo in all DS cases and in 1 case with a GEFS+ phenotype; in 5 GEFS+ cases, the variant was inherited from the affected parent. Discussion: This study contributes to the variation spectrum in cases with DS and GEFS+ phenotype with the novel variants detected. SCN1A genetic analysis can help in determining whether antiseizure medication should be selected or avoided in cases with variations. The elucidation of the molecular etiology makes it possible to provide the family with effective genetic counseling for future pregnancies.
Older Adults’ Likelihood of Participating in Home-Based Cognitive Assessment
Authors: Splonskowski Moriah , Jacova Claudia
Published: February 2022

Introduction: Timely detection of cognitive impairment among older adults has shown to lead to better health and financial outcomes but is hampered by psychological, financial, and physical barriers to participation in cognitive assessment. Home-based cognitive assessment (HBCA) could help overcome some of these barriers. This study aimed to examine older adults’ likelihood of participation in HBCA and identify factors predicting this likelihood. Materials and Methods: A cross-sectional online survey distributed through Amazon Mechanical Turk, was used to collect data from adults aged 50 years or older residing in the USA The survey was designed to gauge attitudes toward technology and cognitive assessment and to measure psychological variables including subjective cognitive decline (SCD), depression, and anxiety. Information on income and geographic location (rural vs. suburban and urban) was also collected. Univariate and hierarchical regression analyses were conducted to examine the contributions of these variables to a composite measure of likelihood of participation in HBCA. Results: Complete data were obtained on n = 483 (age 50–79). Approximately, two-thirds of respondents described themselves as likely or very likely to participate in HBCA. In univariate analyses, younger age, higher income, higher technology assessment acceptance scores, and higher SCD burden were associated with higher likelihood of participation. Hierarchical regression revealed significant stepwise increments in explained variance: demographic variables 4.1%, technology acceptance 25.2%, assessment acceptance 15.4%, and SCD burden 1.6%. The contribution of SCD was moderated by sex and found for women but not for men. Discussion/Conclusion: A large proportion of adults aged 50 and above described themselves likely to participate in HBCA. Middle-aged, technology-savvy, higher income adults expressed the most positive attitudes toward this type of service. Of interest is that HBCA may be particularly acceptable among older women with SCD, a group known to be at risk of cognitive decline. Our findings support the expansion of cognitive assessment services to the home setting.
Time‐Dependent Impact of Sex on the Long‐Term Outcomes After Left Main Revascularization
Authors: Yoon Yong‐Hoon , Ahn Jung‐Min , Lee Jung Bok , Kang Do‐Yoon , Park Hanbit , Jeong Yeong Jin , Lee Junghoon , Kim Ju Hyeon , Yang Yujin , Hyun Junho , Lee Pil Hyung , Park Duk‐Woo , Park Seung‐Jung
Published: February 2022

Background

There are still limited data about the differential effect of sex on long‐term outcomes after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for left main coronary artery disease. This extended follow‐up study of the MAIN‐COMPARE (Ten‐Year Outcomes of Stents Versus Coronary‐Artery Bypass Grafting for Left Main Coronary Artery Disease) registry evaluated clinical outcomes beyond 10 years.

Methods and Results

Of 2240 patients with unprotected left main coronary artery disease (PCI=1102 and CABG=1138), all‐cause mortality, the composite of death, Q‐wave myocardial infarction, or stroke, and target vessel revascularization were separately evaluated in both sexes. Of 2240 patients, 631 (28.2%) were women and 1609 (71.8%) were men. Women had lower 10‐year incidences of death and serious composite outcomes than men. The adjusted 10‐year risks of adverse outcomes were similar in men. However, the adjusted 10‐year risks were different according to a prespecified period in women. In the short‐term (0–1 year) period, PCI had a significantly lower risk for serious composite outcomes (adjusted hazard ratio [HR], 0.41; 95% CI, 0.19–0.91;
P
=0.03) compared with CABG. The adjusted risks for death and serious composite outcomes were significantly higher after PCI than after CABG, during the midterm (1–5 years) period (death; adjusted HR, 3.99; 95% CI, 2.01–7.92;
P
<0.001 and composite outcome; adjusted HR, 2.93; 95% CI, 1.59–5.39;
P
=0.001). Beyond 5 years, adjusted risks were similar after PCI and CABG in women.

Conclusions

In this 10‐year extended follow‐up study of patients undergoing left main coronary artery revascularization, we observed a time‐dependent impact of sex on the long‐term outcomes after PCI and CABG, especially in women, with significant interactions. However, these results warrant confirmation on larger series of studies.

Registration

URl:
https://www.clinicaltrials.gov
; Unique identifier: NCT02791412.
Gender Differences in International Cardiology Guideline Authorship: A Comparison of the US, Canadian, and European Cardiology Guidelines From 2006 to 2020
Authors: Rai Devesh , Kumar Ashish , Waheed Syed Hamza , Pandey Ritambhara , Guerriero Miranda , Kapoor Ankita , Tahir Muhammad Waqas , Zahid Salman , Hajra Adrija , Balmer‐Swain Mallory , Castelletti Silvia , Maas Angela H. E. M. , Grapsa Julia , Mulvagh Sharon , Zieroth Shelley , Kalra Ankur , Michos Erin D. , Gulati Martha
Published: February 2022

Background

Women continue to be underrepresented in cardiology and even more so in leadership positions. We evaluated the trends and gender differences in the guideline writing groups of the American College of Cardiology/American Heart Association (ACC/AHA), Canadian Cardiovascular Society (CCS), and European Society of Cardiology (ESC) guidelines from 2006 to 2020.

Methods and Results

We extracted all guidelines authors from 2006 to 2020, assessed their gender from publicly available profiles, and compared differences based on subspecialties and specific societies. Stratified and trend analyses were performed using χ
2
and average annual percentage change/average 5 year percentage change. A total of 80 ACC/AHA (1288 authors [28% women]), 64 CCS (988 authors [26% women]), and 59 ESC (1157 authors [16% women]) guidelines were analyzed. A significant increase in inclusion of women was seen in ACC/AHA (12.6% [2006] to 42.6% [2020]; average annual percentage change, 6.6% [2.3% to 11.1%];
P
=0.005) and ESC (7.1% [2006] to 25.8% [2020]; average annual percentage change, 6.6% [0.2% to 13.5%];
P
=0.04), but the trend remained similar in CCS (20.6% [2006] to 36.3% [2020]; average annual percentage change, −0.1% (−3.7% to 3.5%);
P
=0.94), guideline authors. More women were coauthors in the ACC/AHA and ESC guidelines when women were chairs of guidelines. There was a persistent disparity of women among guideline authors for general cardiology and all subspecialties, except for pediatric cardiology and heart failure guidelines. The appointment of women authors as a chair was significantly low in all societies (22.4% [ACC/AHA], 16.9% [CCS], and 7.2% [ESC];
P
=0.008).

Conclusions

There is a significant disparity in the inclusion of women on all national guideline committees, in addition to serving as a chair of cardiology guidelines. Further advocacy is required to promote equity, diversity, and inclusion in our cardiology guidelines globally.
The Diverse Roles of Bangladesh’s Diaspora Communities in Jihadism
Authors: Mostofa Shafi Md
Published: February 2022

Diaspora radicalisation has increasingly become a source of major concern for home and host countries, especially with technology facilitating easier communication with the global village. The popular perception used to be that expatriates were less vulnerable to radicalisation, but this paper argues that in reality the scenario is completely different. Using a desk-based literature review and interviews in Dhaka, and focusing on the Bangladeshi diaspora, the findings of the study show that members of the diaspora communities have increasingly been targeted, or indeed target other members, for radicalisation. Radical expatriates have not only recruited new members online and raised funds to support terrorism, they have also provided charismatic leadership, thereby directing extremist groups from the front.
Supplement to the Burmese (Myanmar) amber checklist and bibliography, 2021
Authors: ROSS ANDREW J.
Published: February 2022

This is a supplement to the Burmese (Myanmar) amber checklist and bibliography covering taxa described or recorded during 2021, plus a few earlier records that were missed previously. Up to the end of 2021, 2,198 species were recorded from Kachin amber of which 337 were named in 2021. Five species were named or recorded from older Hkamti amber.
A hangingfly (Mecoptera, Bittacidae) from the late Oligocene Fossillagerstätte Enspel, Westerwald (SW Germany)
Authors: POSCHMANN MARKUS J. , NEL ANDRÉ
Published: February 2022

A hangingfly (Mecoptera, Bittacidae) is described from bituminous shales of the late Oligocene crater-lake of Enspel, Germany. It is attributed to a new species, Eremobittacus opeth sp. nov., and constitutes the first post-Eocene record of fossil hangingflies from Germany. The genus Eremobittacus was hitherto exclusively known from Mexico. Its presence in the Oligocene of Germany is a further case of insect dispersion between North America and Europe, via the Beringian, the Thulean, or the De Geer routes during the Paleogene.
Chronic Obstructive Sialadenitis due to an Abnormal Wharton’s Duct Draining to the Tonsillar Fossa
Authors: Sánchez Barrueco Alvaro , Guerra Gutiérrez, MD Félix , Díaz Tapia Gonzalo , Cenjor Español Carlos
Published: February 2022

Introduction:

Chronic obstructive sialadenitis (COS) is an entity that causes a marked loss in patient quality of life, including changes in eating habits and a progressive loss of gland function. It is characterized by repeated episodes of painful glandular swelling often requiring emergency care. There are multiple causes of COS, including lithiasis, strictures, anatomical variants, and others. The development of specific imaging tests such as magnetic resonance (MR) sialography or sialendoscopy have increased knowledge of these obstructions and how to specifically treat them.

Case Summary:

We present an unusual case of a woman with a years-long history of chronic obstructive sialadenitis in which an abnormal path of Wharton’s duct was in evidence. This duct, which was atrophic and smaller in diameter, opened in the tonsillar fossa rather than lateral to the lingual frenulum. This case, the first in vivo description of its kind, was confirmed by MR sialography and sialendoscopy.

Discussion:

Congenital anomalies of the submandibular duct are a rare finding, but may cause COS. Therefore, COS requires a detailed diagnostic study, usually by ultrasound, MR sialography and sialendoscopy, to rule out complex anatomical variants.
Political Settlements and the Management of Cocoa Value Chain in Ghana
Authors: Teye Joseph Kofi , Nikoi Ebenezer
Published: February 2022

This paper relies on literature review and primary data collected through in-depth interviews with 21 respondents to examine the political economy dynamics of the cocoa value chain in Ghana. The historical analysis, which was based on the political settlements framework, has shown that the policies implemented in the cocoa sector went through four periods. The colonial era was characterised by a fairly corporate governance system and struggle between European traders and farmer cooperatives for monopoly over internal marketing of cocoa. This was followed by the early post-independence era (1957–1980), which was characterised by neopatrimonialism and over-taxation of cocoa farmers. The third phase (1980–2000) witnessed economic reforms and liberalisation. The fourth phase (2000 to present) saw increased public–private partnerships aimed at empowering women and promoting environmentally friendly farming activities. The paper concludes that the policies in the cocoa sector have, historically, created more benefits (rents) to political elite and their crony capitalists. Given that rent-seeking behaviour is a threat to the sustainability of the cocoa sector, the paper urges international development partners and civil society groups to demand greater accountability and transparency from the political elite and state institutions in the cocoa sector.
Recidivism in Context: A Meta-Analysis of Neighborhood Concentrated Disadvantage and Repeat Offending
Authors: Jacobs Leah A. , Ashcraft Laura Ellen , Sewall Craig J. R. , Wallace Danielle , Folb Barbara L.
Published: February 2022

This study meta-analytically examined the effect of macro-level concentrated disadvantage on individual-level recidivism. Search results indicated research to date is designed to assess the incremental effect of concentrated disadvantage on recidivism above other risk factors. Using a multilevel random effects model, we found the estimated incremental effect of concentrated disadvantage was nonsignificant (log odds ratio = 0.03, p = .15, k = 48). However, effects varied by recidivism and offense type. Concentrated disadvantage does not add incremental utility when predicting general recidivism, but it does add incremental utility when assessing arrests (especially drug arrests) and violent reconvictions. Although individual-level risk factors and markers seem to explain most of the relationship between concentrated disadvantage and reoffending, concentrated disadvantage should not be summarily dismissed as irrelevant to recidivism. The overrepresentation of disadvantaged neighborhoods among the justice-involved—and the overrepresentation of the justice-involved in disadvantaged neighborhoods—requires further research on the disadvantage–recidivism relationship.
When and Why People Prefer Higher Educated Politicians: Ingroup Bias, Deference, and Resistance
Authors: van Noord Jochem , Kuppens Toon , Spruyt Bram , Spears Russell
Published: February 2022

When choosing between political candidates of different educational levels, do voters show ingroup bias or base their vote choice on candidates’ perceived competence? We aim to investigate how (fictional) political candidates of different educational levels are evaluated and voted for, how this is affected by voters’ educational level, and the role of perceived (Study 1) and manipulated competence (Study 2). Higher educated participants preferred higher to less educated candidates over and above their level of competence, particularly when they identified strongly with their educational level. This reflects ingroup bias among the higher educated. Less educated participants preferred higher educated candidates in Study 1, but did not prefer higher educated candidates when competence was manipulated independently from education in Study 2. The less educated, unlike the higher educated, therefore, seem to show deference to the assumed competence of the higher educated, because it disappears when more reliable competence information is available.
Success of Implantable Doppler Probes for Monitoring Buried Free Flaps
Authors: Dunklebarger Mitchell Frye , McCrary Hilary , King Brody , Carpenter Patrick , Buchmann Luke , Hunt Jason , Cannon Richard
Published: February 2022

Objective

The objective of this study is to describe the operative success of completely buried free flaps and to determine the safety/reliability of using implantable dopplers for postoperative monitoring in completely buried free flaps.

Study Design

A retrospective chart review was conducted from 2014 to 2020. Patients were included who had implantable dopplers placed for monitoring a completely buried free flap without a visible skin paddle.

Setting

Single academic cancer hospital.

Methods

Patient charts were reviewed to determine flap viability after surgery, need for reoperation, and ability of implanted doppler probes to detected change in free flap status.

Results

A total of 65 patients were included. Locations of flaps were as follows: pharynx, 76.9%; skull base, 7.7%; trachea, 6.2%; esophagus, 4.6%; and facial reanimation, 4.6%. Types of free flaps performed included radial forearm (50.8%), anterolateral thigh (44.6%), and gracilis (4.6%). One patient (1.5%) returned to the operating room for vascular compromise, which was accurately detected by the implantable doppler and salvaged. All free flaps were viable upon hospital discharge based on clinical examination and implantable doppler signals. There were no complications related to implantable doppler use.

Conclusions

Implantable dopplers are an effective method for evaluating postoperative success of completely buried free flaps. In our series utilizing implantable dopplers, buried free flap survival was higher than traditionally thought. The use of implanted dopplers for monitoring buried free flaps allows for an effective, cosmetically appealing, and simplified reconstructive technique.
Denials ‘From Seabed to Space’: Assemblages of (In)Security and Denial in the Politics of Security
Authors: Mnatsakanyan Tatevik
Published: February 2022

Despite critiques of denials broadly underlying Critical International Relations deconstructions of state, security and subjectivity, there is little explicit exploration of the ontological status of denial, and how denials operate in the politics of (in)security. Animated by the question, why and how web of actors and interests traversing the public and private spheres involved in the provision of security endure despite long-running critique, this article problematises = denials. An explicit theorisation of denial needs to be put centre stage in the study of security. Drawing on Dillon’s theorisation of the unstable duality of (in)security and synthesising it with a Deleuze and Guattarian assemblage approach, it theorises denial in two forms – denial of complicity and denial of the impossibility of security – as ontologically necessary for the politics of (in)security; then proposes that we scrutinise and expose assemblages of (in)security. These assemblages form, endure and expand, by thriving on denials of the impossibility of security and its attendant complicities; forming symbioses of denial traversing the public-private realms. Assemblages of (in)security adapt, expand, and propagate new technologies of (in)security, often ironically by responding to demands from critique. Without an assemblage-based thinking, we are methodologically ill-equipped to trace, expose and critique the politics of (in)security, without unwittingly partaking in denials sustaining it.

Des dénis « du fond des océans jusqu’à l’espace » : agencements d’(in)sécurité et déni dans la politique de sécurité
Opioid use disorder in anaesthesia and intensive care: Prevention, diagnosis and management
Authors: Murnion Bridin P , Demirkol Apo
Published: February 2022

Opioid misuse is common, as is opioid agonist treatment of opioid dependence. Almost 3% of Australians and over 3.5% of those living in New Zealand report misuse of analgesics. Over 50,000 Australians receive opioid agonist treatment with methadone or buprenorphine for management of severe opioid use disorder.

The perioperative period is an opportunity to identify pre-existing opioid misuse, and to introduce interventions to reduce the risk of development of opioid use disorder. Challenges of acute perioperative pain management or intensive care management of patients receiving opioid agonist treatment include opioid tolerance and ongoing prescribing of methadone or buprenorphine. There has been some ambiguity about the optimal perioperative management of buprenorphine, a partial agonist at the mu receptor.

In this article, a framework to identify emerging opioid misuse problems, identify risk of overdose and to manage the opioid-dependent patient on opioid agonist treatment perioperatively or in the intensive care unit is provided. Diagnostic criteria and risk stratification criteria are presented. Management strategies include trauma-informed care, care planning and care coordination with community practitioners and opioid agonist treatment providers. Continuing methadone or buprenorphine perioperatively with additional opioid and non-opioid analgesia is generally recommended. Increased opioid agonist treatment doses may be required on discharge. An algorithm for decisions about opioid agonist treatment management in the intensive care unit based on the risks of opioid withdrawal and toxicity is considered. Strategies for managing the opioid-dependent patient who is not in treatment are also discussed.
Violence, co-optation, and postwar voting in Guatemala
Authors: Villamil Francisco
Published: February 2022

Wartime civilian victimization produces a counter-reaction against the perpetrator. However, this effect hinges on the creation of collective memories of wartime events. In many countries, former fighting actors and political elites try to redirect memories of wartime events through denial, propaganda, and co-optation. Previous works have ignored these aspects. I argue that the effect of violence is conditional on the capacity of local communities to build collective memories and bypass those efforts. I test this argument using local-level data from Guatemala. The results show that the effects of state violence on postwar voting depend on prewar exposure to political mobilization.
From One Generation to the Next: Hmong American Adolescents’ Views of Maternal Racial Socialization
Authors: Lamborn Susie D. , Paasch-Anderson Julie
Published: February 2022

This study investigated Hmong American adolescents’ perceptions of their mother as helping them understand race as Asian American youths in an urban context. Twenty-four Hmong American adolescents ages 14 to 18 ( M = 15.8; 67% female; 54% U.S. born, 46% born in Southeast Asia) participated in semi-structured interviews, following approval of the Institutional Review Board. Directed content analysis revealed three themes of racial, ethnic, and neutral socialization practices. Frequently, responses reflected the categories of racism awareness, racial group identification, and diversity awareness, as well as no discussion of race (racial socialization theme). Although the study asked specifically about racial socialization, some responses indicated that mothers engaged in cultural practices that included cultural markers and ethnic group identification (ethnic socialization theme). A few responses also represented neutral socialization that emphasized good behavior. Emergent categories included intra-racial discrimination and bicultural socialization. More frequently than girls, boys reported having discrimination experiences without discussing race with mothers. Girls reported more intra-racial discrimination messages, as well as bicultural and neutral messages than boys. These findings can help Hmong American adolescents and their families continue to build successful strategies for dealing with racism and discrimination, and support understanding how Asian Americans address racialized experiences in the U.S.
Stimulation of Lactation Using Acupuncture: A Case Study
Authors: Pierdant Guillermo , Westphal Kristin , Lange Anja , Usichenko Taras I.
Published: February 2022

Introduction:

Breastfeeding is a recognized preferred method of infant feeding; however, for many women, difficulties in breastfeeding result in termination before the recommended period of time. Acupuncture is suggested to be a promising option to treat lactation insufficiency and enhance the production of maternal milk.

Main Issue:

We have reported the case of a woman with lactation insufficiency due to Caesarean section and congenital unilateral invaginated nipple. Milk production started on the 3rd day following delivery. The newborn was not provided with any food or fluids other than mother’s milk. At 5 days of life, the newborn required long feeding periods and lost 4% of his birth weight, with the participant reporting lactation insufficiency described by the perception of inadequate milk production.

Management:

Despite the implementation of conventional measures to improve lactation, the difficulties in breastfeeding persisted. Acupuncture was tried on Day 6 of life, and enhanced milk production was observed, which could be measured as the volume of residual milk extracted using the breast pump each time after the newborn achieved satiety. After acupuncture treatment there was an augmentation of maternal milk production from both breasts and successful lactation.

Conclusion:

This case study provides information that might be useful for prospective investigation of acupuncture’s efficacy in women with lactation insufficiency.
Acting Like a Baby Boomer? Birth-Cohort Differences in Adults’ Personality Trajectories During the Last Half a Century
Authors: Brandt Naemi D. , Drewelies Johanna , Willis Sherry L. , Schaie K. Warner , Ram Nilam , Gerstorf Denis , Wagner Jenny
Published: February 2022

Society and developmental theory generally assume that there are wide generational differences in personality. Yet evidence showing historical change in the levels of adult Big Five traits is scarce and particularly so for developmental change. We tracked adult trajectories of personality in 4,732 participants (age: M = 52.93 years, SD = 16.69; 53% female) from the Seattle Longitudinal Study (born 1883–1976) across 50 years. Multilevel models revealed evidence for historical change in personality: At age 56, later-born cohorts exhibited lower levels of maturity-related traits (agreeableness and neuroticism) and higher levels of agency-related traits (extraversion and openness) than earlier-born cohorts. Historical changes in agreeableness and neuroticism were more pronounced among young adults, but changes in openness were less pronounced. Cohort differences in change were rare and were observed only for agreeableness; within-person increases were more pronounced among later-born cohorts. Our results yield the first evidence for historical change in the Big Five across adulthood and point to the roles of delayed social-investment and maturity effects.
A Bayesian phase I/II biomarker-based design for identifying subgroup-specific optimal dose for immunotherapy
Authors: Guo Beibei , Zang Yong
Published: February 2022

Immunotherapy is an innovative treatment that enlists the patient’s immune system to battle tumors. The optimal dose for treating patients with an immunotherapeutic agent may differ according to their biomarker status. In this article, we propose a biomarker-based phase I/II dose-finding design for identifying subgroup-specific optimal dose for immunotherapy (BSOI) that jointly models the immune response, toxicity, and efficacy outcomes. We propose parsimonious yet flexible models to borrow information across different types of outcomes and subgroups. We quantify the desirability of the dose using a utility function and adopt a two-stage dose-finding algorithm to find the optimal dose for each subgroup. Simulation studies show that the BSOI design has desirable operating characteristics in selecting the subgroup-specific optimal doses and allocating patients to those optimal doses, and outperforms conventional designs.
Dignity of Nursing Students in Clinical Learning Environments
Authors: Tehranineshat Banafsheh , Torabizadeh Camellia
Published: February 2022

As an important professional value, dignity has always been an ethical concern in nursing education and practice. However, the dignity of nursing students in clinical environments has remained a little-discussed topic. This study aims to explore and describe nursing students’ dignity in clinical learning environments. This study is a qualitative descriptive work in which data were collected via semi-structured, in-depth, individual interviews and subsequently analyzed according to conventional content analysis. Based on the inclusion criteria of the study, nursing students were selected from different departments of university hospitals in the south of Iran from October 2019 to December 2020 (n = 21). Sampling continued to the point of data saturation. This study has been approved by the institutional review board of the university. Two themes emerged from the data collected in the interviews: trust-based relationships and formation of professional identity. The findings of the study show that nursing students need to be supported by their instructors and perceive that the personnel and patients believe in their ability. In an effectively supportive, trust-based atmosphere, these factors can contribute to maintaining nursing students dignity. Also, showing respect for their personal identity, projecting a positive image of nursing, and giving them authority to perform executive and clinical tasks in hospital departments play a major role in the formation of nursing students’ professional identity and development of their dignity. Accordingly, it is recommended that in cultural contexts and clinical learning environments, more attention should be given to nursing students’ dignity.
Nurses’ Working Experiences of Their Provision of Cross-Cultural Services to Tibetan Patients With Kashin–Beck Disease: A Qualitative Study
Authors: Tan Rong , Zhou Wenjuan , Ye Shunan , Teng Fen , Zhang Jingshuo
Published: February 2022

Introduction:

Limited qualitative studies exist on nurses’ experience in terms of communicating with and caring for patients with endemic diseases. The purpose of this study was to describe the working experiences of nurses caring for Tibetan patients with Kashin–Beck disease in China.

Method:

A qualitative design was used in this study. Sixteen nurses who worked in the orthopedics department of a large tertiary general hospital in Wuhan, China, constituting a purposive sample, were interviewed face-to-face using semi-structured guided questions.

Results:

Three major themes and nine subthemes were identified. Major themes included the challenge in cross-cultural nursing, stress adjustment in cross-cultural nursing, and reshaping competencies in cross-cultural nursing.

Discussion:

This study revealed that nurses encountered multifaceted challenges when caring for Tibetan patients with Kashin–Beck disease. In a multiethnic society, communication and language skills, cultural competency and cultural sensitivity, and diverse training methods to improve cross-cultural knowledge could increase ethnic minority patient satisfaction with cross-cultural care.
Conceptualizing the dark ride experience through the Dark Ride Cube: Evidence from the EMEA region
Authors: Cornelis Pieter C. M. , Strijbosch Wim , Corsius Philip
Published: February 2022

Dark rides are archetypal theme park attractions that provide compelling experiences through carefully structured experience designs. In a literature review, we follow and slightly modify Langhof and Güldenberg’s conceptualization of the dark ride experience (DRE) and suggest that the DRE mostly consists of narrative transportation, presence, flow, and emotions. However, to what extent these conceptualizations match actual dark ride supply remains unexamined. Therefore, we evaluate 238 dark rides in the EMEA region on product determinants of the DRE and compare literature-based conceptualizations of the DRE against actual dark ride supply. Findings indicate that dark rides highly vary in terms of storytelling, theming, and pervasive interactivity, thus questioning whether all components of the DRE always apply to the full dark ride spectrum. Proposing the Dark Ride Cube as a dark ride typology, Langhof and Güldenberg’s conceptualization of the DRE is largely confirmed, as well as the currently suggested modifications.
Choriocapillaris alteration in patients with paracentral acute middle maculopathy
Authors: Maltsev Dmitrii S. , Kulikov Alexei N. , Burnasheva Maria A.
Published: February 2022

Purpose

To evaluate with optical coherence tomography angiography the status of the choriocapillaris in the eyes of patients with resolved paracentral acute middle maculopathy (PAMM).

Methods

Nine patients with unilateral resolved PAMM, 14 age-matched healthy individuals, and 16 age-matched patients with unilateral retinal vein occlusion (RVO) were included. The choriocapillaris flow area, and the number of choriocapillaris flow voids was compared between the eyes of healthy individuals, both eyes of the PAMM patients, and the fellow eyes of unilateral RVO patients.

Results

The number of choriocapillaris flow voids in the unaffected eyes of PAMM patients was statistically significantly higher than in the eyes of healthy individuals (p < 0.001) and in the fellow eyes of unilateral RVO patients (p = 0.022). The choriocapillaris flow area in the unaffected eyes of PAMM patients was statistically significantly lower than in the eyes of healthy individuals (p < 0.001) and in the fellow eyes of unilateral RVO patients (p = 0.019). There was no difference in the status of the choriocapillaris between two eyes of PAMM patients.

Conclusion

Eyes of patients with resolved PAMM have a substantial decrease of choriocapillaris perfusion.
Comparison of Fluorescein Angiography Findings in Stage 3 Retinopathy of Prematurity in Zone II Treated With or Without Anti-VEGF
Authors: Vural Aslı , Demirayak Bengi , Ozbas Mehmet , Onur I. Umut , Celik Gökhan
Published: February 2022

Purpose

To define late-stage fluorescein angiography (FA) findings in patients who received anti-vascular endothelial growth factor (VEGF) agents (intravitreal bevacizumab or aflibercept) as a treatment for stage 3 retinopathy of prematurity (ROP) in zone II. We also compared the findings of untreated eyes.

Method

Infants with a history of ROP who underwent fluorescein angiography were evaluated retrospectively. The patients were divided into 2 groups: those who received anti-VEGF treatment and those who regressed spontaneously without treatment. Vascular abnormalities, such as vascular leakage, shunts at the vascular-avascular junction, periarteriolar areas with hypoperfusion, fine branching and blunt termination of the vessels and, were recorded.

Results

Angiography evaluations revealed leakage in the eyes of 27.69% of the infants in the anti-VEGF–treated group and in 21.7% of the untreated group ( p = .638). Among the abnormal vascular findings in the peripheral retina, the ratios of fine branching and blunt termination, numbers of shunts along the vascular-avascular junction, and sizes of periarteriolar areas of hypoperfusion were significantly larger in the untreated group than in the treated group ( p < .05; p < .01). The gestational ages and birth weights were significantly lower ( p ≤ .05) in infants with vascular findings in both groups.

Conclusion

Vascular abnormalities in the peripheral retina are likely due to the ROP itself. Although these abnormalities were detected by FA imaging in both treated and untreated infants with ROP, they were significantly less frequent in patients treated with anti-VEGF, indicating that anti-VEGF treatments have a partially positive effect on the retinal vascularization process.
Study on nonlinear vibration of flexible electronic membrane engendered by high-precision imprinting system
Authors: Feng Yao , Wu Jimei , Wang Yan , Shao Mingyue
Published: February 2022

In the process of guide roller transmission, the geometric nonlinearity caused by the lateral vibration of the flexible electronic membrane will result in the divergence and instability of the membrane velocity, thus affecting the printing accuracy. In this paper, in order to engineer the exact condition that affecting the printing accurancy, the Elliptic integral method, whose effectiveness has been verified for its soluted result, is consistent with the one concluded from L-P method and He's Frequency formula while soluting the nonlinear vibration equation, respectively, on basis of Von Karman’s large deflection theory and Hamilton’s principle, is mainly applied, and thus provide a theoretical support for the design and manufacture of high-precision flexible electronic printing press.
Boston Carpal Tunnel Questionnaire Scores Alone Do Not Predict Surgical Intervention for Patients With Carpal Tunnel Syndrome
Authors: Chen Frank R. , Kerluku Jona , Manzi Joseph E. , Chen Aaron Z. , Nguyen Joseph T. , Wessel Lauren E. , Osei Daniel A. , Fufa Duretti T.
Published: February 2022

Background:

With the expanded indications for telemedicine, there is increased utility for screening methods to determine which patients are likely to progress to surgical intervention, requiring in-person visits. Patient-rated tools such as the Boston Carpal Tunnel Questionnaire (BCTQ) may be one such tool for screening patients with carpal tunnel syndrome (CTS). The aim of the study was to evaluate whether BCTQ scores were predictive of offering conservative treatment or surgical intervention for CTS.

Methods:

Patients diagnosed with CTS from January 2017 to February 2020 completed BCTQ questionnaires prior to in-person office visits. Demographics, comorbidities, and highest level of intervention recommended were recorded for each patient as conservative, injection, or surgery. Pearson χ2 and independent-samples t tests were conducted to determine whether BCTQ symptom severity and functional scores were associated with intervention type.

Results:

A total of 200 patients with CTS were included. Of these, 103 were recommended conservative or injection treatment and 97 were recommended surgery. There were no differences in comorbidities between groups, including other upper extremity pathology ( P = .57), previous upper extremity surgery ( P = .32), hypertension ( P = .17), hypothyroidism ( P = .15), rheumatoid arthritis ( P = .34), and diabetes ( P = .30). Between these groups, there were no differences in BCTQ symptom severity score (symptom severity scale [SSS]; P = .16) or BCTQ functional severity score (functional severity scale [FSS]; P = .96).

Conclusions:

There is no correlation between comorbidities and BCTQ SSS or FSS score, and offering surgery for CTS. In an era of minimizing non-essential health care visits, the BCTQ is insufficient in screening patients as potential surgical candidates.