bluuebunny/crossref_metadata_2025 huggingface dataset:
Matrix Metalloproteinase-7 and Premalignant Host Responses in Helicobacter pylori–Infected Mice
Authors: Ogden Seth R. , Noto Jennifer M. , Allen Shannon S. , Patel Dilan A. , Romero-Gallo Judith , Washington M. Kay , Fingleton Barbara , Israel Dawn A. , Lewis Nuruddeen D. , Wilson Keith T. , Chaturvedi Rupesh , Zhao Zhiguo , Shyr Yu , Peek Richard M.
Published: January 2010

Helicobacter pylori–induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro. Utilizing a transgenic murine model of H. pylori–mediated injury, our experiments now show that gastric inflammation is increased within the context of MMP-7 deficiency, which involves both Th1- and Th17-mediated pathways. Enhanced gastritis in H. pylori–infected mmp-7−/− mice is strongly linked to accelerated epithelial cellular turnover. However, more severe inflammation and heightened proliferation and apoptosis are not dependent on MMP-7–mediated bacterial eradication. Collectively, these studies indicate that H. pylori–mediated induction of MMP-7 may serve to protect the gastric mucosa from pathophysiologic processes that promote carcinogenesis. Cancer Res; 70(1); 30–5
ErbB3 Binding Protein 1 Represses Metastasis-Promoting Gene Anterior Gradient Protein 2 in Prostate Cancer
Authors: Zhang Yuexing , Ali Tehmina Z. , Zhou Hua , D'Souza David R. , Lu Yan , Jaffe Jonathan , Liu Zhenqiu , Passaniti Antonino , Hamburger Anne W.
Published: January 2010

Dysregulation of the developmental gene anterior gradient protein 2 (AGR2) has been associated with a metastatic phenotype, but its mechanism of action and control in prostate cancers is unknown. In this study, we show that overexpression of AGR2 promotes the motility and invasiveness of nonmetastatic LNCaP tumor cells, whereas silencing of AGR2 in the metastatic derivative C4-2B blocks invasive behavior. ErbB3 binding protein 1 (EBP1), a putative repressor of AGR2, is attenuated in prostate cancer. We show that the anti-invasive effect of EBP1 occurs, at least in part, through its ability to inhibit AGR2 expression. Mechanistic investigations indicate that EBP1 downregulates Foxa1- and Foxa2-stimulated AGR2 transcription and decreases metastatic behavior. In contrast, EBP1 ablation upregulates AGR2 via Foxa1- and Foxa2-stimulated AGR2 promoter activity and increases metastatic behavior. In both prostate cell lines and primary tumors, we documented an inverse correlation between EBP1 and AGR2 levels. Collectively, our results reveal an EBP1-Foxa-AGR2 signaling circuit with functional significance in metastatic prostate cancer. Cancer Res; 70(1); 240–8
Functional Genetic Polymorphisms in the Aromatase GeneCYP19Vary the Response of Breast Cancer Patients to Neoadjuvant Therapy with Aromatase Inhibitors
Authors: Wang Liewei , Ellsworth Katarzyna A. , Moon Irene , Pelleymounter Linda L. , Eckloff Bruce W. , Martin Yvette N. , Fridley Brooke L. , Jenkins Gregory D. , Batzler Anthony , Suman Vera J. , Ravi Saranya , Dixon J. Michael , Miller William R. , Wieben Eric D. , Buzdar Aman , Weinshilboum Richard M. , Ingle James N.
Published: January 2010

Aromatase (CYP19) is a critical enzyme in estrogen biosynthesis and aromatase inhibitors (AI) are employed widely for endocrine therapy in postmenopausal women with breast cancer. We hypothesized that single nucleotide polymorphisms (SNPs) in the CYP19 gene may alter the effectiveness of AI therapy in the neoadjuvant setting. Genomic DNA was obtained for sequencing from 52 women pre-AI and post-AI treatment in this setting. Additionally, genomic DNA obtained from 82 samples of breast cancer and 19 samples of normal breast tissue was subjected to resequencing. No differences in CYP19 sequence were observed between tumor and germ-line DNA in the same patient. A total of 48 SNPs were identified including 4 novel SNPs when compared with previous resequencing data. For genotype-phenotype association studies, we determined the levels of aromatase activity, estrone, estradiol, and tumor size in patients pre-AI and post-AI treatment. We defined two tightly linked SNPs (rs6493497 and rs7176005 in the 5'-flanking region of CYP19 exon 1.1) that were significantly associated with a greater change in aromatase activity after AI treatment. In a follow-up study of 200 women with early-stage breast cancer who were treated with adjuvant anastrozole, these same two SNPs were also associated with higher plasma estradiol levels in patients pre-AI and post-AI treatment. Electrophoretic mobility shift and reporter gene assays confirmed likely functional effects of these two SNPs on transcription of CYP19. Our findings indicate that two common genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to aromatase inhibitors. Cancer Res; 70(1); 319–28
VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism
Authors: Carrier Marc , Righini Marc , Djurabi Reza Karami , Huisman Menno , Perrier Arnaud , Wells Philip , Rodger Marc , Wuillemin Walter , Gal Grégoire Le
Published: January 2010

Clinical outcome studies have shown that it is safe to withhold anticoagulant therapy in patients with suspected pulmonary embolism (PE) who have a negative D-dimer result and a low pre-test probability (PTP) either using a PTP model or clinical gestalt. It was the objective of the present study to assess the safety of the combination of a negative VIDAS© D-dimer result in combination with a non-high PTP using the Wells or Geneva models to exclude PE. A systematic literature search strategy was conducted using MEDLINE, EMBASE, the Cochrane Register of Controlled Trials and all EBM Reviews. Seven studies (6 prospective management studies and 1 randomised controlled trial) reporting failure rates at three months were included in the analysis. Non-high PTP was defined as “unlikely” using the Wells’ model, or “low/intermediate” PTP using either the Geneva score, the Revised Geneva Score, or clinical gestalt. Two reviewers independently extracted data onto standardised forms. A total of 5,622 patients with low/intermediate or unlikely PTP were assessed using the VIDAS D-dimer. PE was ruled out by a negative D-dimer test in 2,248 (40%, 95% confidence intervals [CI] 38.7 to 41.3%) of them. The three-month thromboembolic risk in patients left untreated on the basis of a low/intermediate or unlikely PTP and a negative D-dimer test was 3/2,166 (0.14%, 95% CI 0.05 to 0.41%). In conclusion, the combination of a negative VIDAS D-dimer result and a non-high PTP effectively and safely excludes PE in an important proportion of outpatients with suspected PE.
Isn't It Ironic? An Electrophysiological Exploration of Figurative Language Processing
Authors: Regel Stefanie , Gunter Thomas C. , Friederici Angela D.
Published: January 2010

Although the neurocognitive processes underlying the comprehension of figurative language, especially metaphors and idioms, have been studied extensively, less is known about the processing of irony. In two experiments using event-related brain potentials (ERPs), we examined the types of cognitive processes involved in the comprehension of ironic and literal sentences and their relative time course. The experiments varied in modality (auditory, visual), task demands (comprehension task vs. passive reading), and probability of stimulus occurrence. ERPs consistently revealed a large late positivity (i.e., P600 component) in the absence of an N400 component for irony compared to equivalent literal sentences independent of modality. This P600 was shown to be unaffected by the factors task demands and probability of occurrence. Taken together, the findings suggest that the observed P600 is related to irony processing, and might be a reflection of pragmatic interpretation processes. During the comprehension of irony, no semantic integration difficulty arises (absence of N400), but late inferential processes appear to be necessary for understanding ironic meanings (presence of P600). This finding calls for a revision of current models of figurative language processing.
Neural Correlates of Abstract Verb Processing
Authors: Rodríguez-Ferreiro Javier , Gennari Silvia P. , Davies Robert , Cuetos Fernando
Published: January 2010

The present study investigated the neural correlates of the processing of abstract (low imageability) verbs. An extensive body of literature has investigated concrete versus abstract nouns but little is known about how abstract verbs are processed. Spanish abstract verbs including emotion verbs (e.g., amar, “to love”; molestar, “to annoy”) were compared to concrete verbs (e.g., llevar, “to carry”; arrastrar, “to drag”). Results indicated that abstract verbs elicited stronger activity in regions previously associated with semantic retrieval such as inferior frontal, anterior temporal, and posterior temporal regions, and that concrete and abstract activation networks (compared to that of pseudoverbs) were partially distinct, with concrete verbs eliciting more posterior activity in these regions. In contrast to previous studies investigating nouns, verbs strongly engage both left and right inferior frontal gyri, suggesting, as previously found, that right prefrontal cortex aids difficult semantic retrieval. Together with previous evidence demonstrating nonverbal conceptual roles for the active regions as well as experiential content for abstract word meanings, our results suggest that abstract verbs impose greater demands on semantic retrieval or property integration, and are less consistent with the view that abstract words recruit left-lateralized regions because they activate verbal codes or context, as claimed by proponents of the dual-code theory. Moreover, our results are consistent with distributed accounts of semantic memory because distributed networks may coexist with varying retrieval demands.
Learning Shapes the Representation of Visual Categories in the Aging Human Brain
Authors: Mayhew Stephen D. , Li Sheng , Storrar Joshua K. , Tsvetanov Kamen A. , Kourtzi Zoe
Published: January 2010

The ability to make categorical decisions and interpret sensory experiences is critical for survival and interactions across the lifespan. However, little is known about the human brain mechanisms that mediate the learning and representation of visual categories in aging. Here we combine behavioral measurements and fMRI measurements to investigate the neural processes that mediate flexible category learning in the aging human brain. Our findings show that training changes the decision criterion (i.e., categorical boundary) that young and older observers use for making categorical judgments. Comparing the behavioral choices of human observers with those of a pattern classifier based upon multivoxel fMRI signals, we demonstrate learning-dependent changes in similar cortical areas for young and older adults. In particular, we show that neural signals in occipito-temporal and posterior parietal regions change through learning to reflect the perceived visual categories. Information in these areas about the perceived visual categories is preserved in aging, whereas information content is compromised in more anterior parietal and frontal circuits. Thus, these findings provide novel evidence for flexible category learning in aging that shapes the neural representations of visual categories to reflect the observers' behavioral judgments.
The Functional and Neural Mechanism of Action Preparation: Roles of EBA and FFA in Voluntary Action Control
Authors: Kühn Simone , Keizer André W. , Rombouts Serge A. R. B. , Hommel Bernhard
Published: January 2010

Ideomotor theory claims that actions are cognitively represented and accessed via representations of the sensory effects they evoke. Previous studies provide support for this claim by showing that the presentation of action effects primes activation in corresponding motor structures. However, whether people actually use action-effect representations to control their motor behavior is not yet clear. In our fMRI study, we had participants prepare for manual or facial actions on a trial-by-trial basis, and hypothesized that preparation would be mediated by the cortical areas that code for the perceptual effects of these actions. Preparing for manual action induced higher activation of hand-related areas of motor cortex (demonstrating actual preparation) and of the extrastriate body area, which is known to mediate the perception of body parts. In contrast, preparing for facial action induced higher activation of face-related motor areas and of the fusiform face area, known to mediate face perception. These observations provide further support for the ideomotor theory and suggest that visual imagery might play a role in voluntary action control.
A Neurocomputational Model of Dopamine and Prefrontal–Striatal Interactions during Multicue Category Learning by Parkinson Patients
Authors: Moustafa Ahmed A. , Gluck Mark A.
Published: January 2010

Most existing models of dopamine and learning in Parkinson disease (PD) focus on simulating the role of basal ganglia dopamine in reinforcement learning. Much data argue, however, for a critical role for prefrontal cortex (PFC) dopamine in stimulus selection in attentional learning. Here, we present a new computational model that simulates performance in multicue category learning, such as the “weather prediction” task. The model addresses how PD and dopamine medications affect stimulus selection processes, which mediate reinforcement learning. In this model, PFC dopamine is key for attentional learning, whereas basal ganglia dopamine, consistent with other models, is key for reinforcement and motor learning. The model assumes that competitive dynamics among PFC neurons is the neural mechanism underlying stimulus selection with limited attentional resources, whereas competitive dynamics among striatal neurons is the neural mechanism underlying action selection. According to our model, PD is associated with decreased phasic and tonic dopamine levels in both PFC and basal ganglia. We assume that dopamine medications increase dopamine levels in both the basal ganglia and PFC, which, in turn, increase tonic dopamine levels but decrease the magnitude of phasic dopamine signaling in these brain structures. Increase of tonic dopamine levels in the simulated PFC enhances attentional shifting performance. The model provides a mechanistic account for several phenomena, including (a) medicated PD patients are more impaired at multicue probabilistic category learning than unmedicated patients and (b) medicated PD patients opt out of reversal when there are alternative and redundant cue dimensions.
Cross-modal Interactions during Perception of Audiovisual Speech and Nonspeech Signals: An fMRI Study
Authors: Hertrich Ingo , Dietrich Susanne , Ackermann Hermann
Published: January 2010

During speech communication, visual information may interact with the auditory system at various processing stages. Most noteworthy, recent magnetoencephalography (MEG) data provided first evidence for early and preattentive phonetic/phonological encoding of the visual data stream—prior to its fusion with auditory phonological features [Hertrich, I., Mathiak, K., Lutzenberger, W., & Ackermann, H. Time course of early audiovisual interactions during speech and non-speech central-auditory processing: An MEG study. Journal of Cognitive Neuroscience, 21, 259–274, 2009]. Using functional magnetic resonance imaging, the present follow-up study aims to further elucidate the topographic distribution of visual–phonological operations and audiovisual (AV) interactions during speech perception. Ambiguous acoustic syllables—disambiguated to /pa/ or /ta/ by the visual channel (speaking face)—served as test materials, concomitant with various control conditions (nonspeech AV signals, visual-only and acoustic-only speech, and nonspeech stimuli). (i) Visual speech yielded an AV-subadditive activation of primary auditory cortex and the anterior superior temporal gyrus (STG), whereas the posterior STG responded both to speech and nonspeech motion. (ii) The inferior frontal and the fusiform gyrus of the right hemisphere showed a strong phonetic/phonological impact (differential effects of visual /pa/ vs. /ta/) upon hemodynamic activation during presentation of speaking faces. Taken together with the previous MEG data, these results point at a dual-pathway model of visual speech information processing: On the one hand, access to the auditory system via the anterior supratemporal “what” path may give rise to direct activation of “auditory objects.” On the other hand, visual speech information seems to be represented in a right-hemisphere visual working memory, providing a potential basis for later interactions with auditory information such as the McGurk effect.
Perceptual Basis of Redundancy Gains in Visual Pop-out Search
Authors: Töllner Thomas , Zehetleitner Michael , Krummenacher Joseph , Müller Hermann J.
Published: January 2010

The redundant-signals effect (RSE) refers to a speed-up of RT when the response is triggered by two, rather than just one, response-relevant target elements. Although there is agreement that in the visual modality RSEs observed with dimensionally redundant signals originating from the same location are generated by coactive processing architectures, there has been a debate as to the exact stage(s)—preattentive versus postselective—of processing at which coactivation arises. To determine the origin(s) of redundancy gains in visual pop-out search, the present study combined mental chronometry with electrophysiological markers that reflect purely preattentive perceptual (posterior-contralateral negativity [PCN]), preattentive and postselective perceptual plus response selection-related (stimulus-locked lateralized readiness potential [LRP]), or purely response production-related processes (response-locked LRP). As expected, there was an RSE on target detection RTs, with evidence for coactivation. At the electrophysiological level, this pattern was mirrored by an RSE in PCN latencies, whereas stimulus-locked LRP latencies showed no RSE over and above the PCN effect. Also, there was no RSE on the response-locked LRPs. This pattern demonstrates a major contribution of preattentive perceptual processing stages to the RSE in visual pop-out search, consistent with parallel-coactive coding of target signals in multiple visual dimensions [Müller, H. J., Heller, D., & Ziegler, J. Visual search for singleton feature targets within and across feature dimensions. Perception & Psychophysics, 57, 1–17, 1995].
The Neural Substrates and Timing of Top–Down Processes during Coarse-to-Fine Categorization of Visual Scenes: A Combined fMRI and ERP Study
Authors: Peyrin Carole , Michel Christoph M. , Schwartz Sophie , Thut Gregor , Seghier Mohamed , Landis Theodor , Marendaz Christian , Vuilleumier Patrik
Published: January 2010

Spatial frequencies in an image influence visual analysis across a distributed, hierarchically organized brain network. Low spatial frequency (LSF) information may rapidly reach high-order areas to allow an initial coarse parsing of the visual scene, which could then be “retroinjected” through feedback into lower level visual areas to guide finer analysis on the basis of high spatial frequency (HSF). To test this “coarse-to-fine” processing scheme and to identify its neural substrates in the human brain, we presented sequences of two spatial-frequency-filtered scenes in rapid succession (LSF followed by HSF or vice versa) during fMRI and ERPs in the same participants. We show that for low-to-high sequences (but not for high-to-low sequences), LSF produces a first increase of activity in prefrontal and temporo-parietal areas, followed by enhanced responses to HSF in primary visual cortex. This pattern is consistent with retroactive influences on low-level areas that process HSF after initial activation of higher order areas by LSF.
Frank disputations
Authors: Alam Muzaffar , Subrahmanyam Sanjay
Published: January 2010

The essay sets out to re-examine the relations between Catholics and Muslims in the Mughal court in the early seventeenth century, during the reign of Emperor Jahangir (r. 1605–27). It does so by confronting two sets of source–materials, namely the letters of the Jesuit Jerónimo Xavier and Persian–language texts from the Mughal court. In particular it focuses on the important and neglected figure of Maulana ‘Abdus Sattar ibn Qasim Lahauri, an intellectual who worked with and also studied the Europeans. The recent publication of a hitherto unknown text by him, under the title of Majālis-i Jahāngīrī, is in part the occasion for us to return to this classic theme in the historiography of cross-cultural encounters.
Did globalisation aid industrial development in colonial India? A study of knowledge transfer in the iron industry
Authors: Roy Tirthankar
Published: January 2010

The article explores the link between international economic integration and technological capability in colonial India. The example of the iron industry shows that many new ideas and skills flowed into India from Europe, but not all met with commercial success. The essay suggests a reason why. In those fields in which the costs of complementary factors were relatively low, the chance of success was higher. This condition was present in the craft of the blacksmith, in which the main complementary input was abundant craftsmanship. The condition was slow to develop in iron-smelting, where the costs of fuel, labour, capital and carriage of ore were initially high.
Predictive Validity of the MMPI-2 PSY-5 Scales and Facets for Law Enforcement Officer Employment Outcomes
Authors: Caillouet Beth A. , Boccaccini Marcus T. , Varela Jorge G. , Davis Robert D. , Rostow Cary D.
Published: January 2010

Several Minnesota Multiphasic Personality Inventory—2 Personality Psychopathology Five (PSY-5) scales and facets showed small to medium levels of predictive validity in identifying law enforcement officer applicants who would later be forced to leave their agencies ( n = 436 still employed, n = 164 forced to leave agency). The PSY-5 measures were moderately to strongly associated with measures of positive impression management (L and K scales), although the direction of these associations sometimes varied for facets of the same PSY-5 scale (e.g., Disconstraint, Introversion/Low Positive Emotionality). The predictive effects of the PSY-5 were often observed only in officers without significant levels of impression management (L ≤ 55T, K ≤ 65T). The PSY-5 scales and facets were not especially useful for predicting on-the-job misconduct.
The Contribution of Psychiatric Disorder to Juvenile Recidivism
Authors: McReynolds Larkin S. , Schwalbe Craig S. , Wasserman Gail A.
Published: January 2010

Youths formally referred to probation authorities in Texas (791 male, 200 female) self-administered a structured diagnostic interview at intake. Data on demographics, offense characteristics, and reoffending (within 12 months of baseline) were extracted from official justice records. Logistic regression analyses were used to evaluate the contribution of diagnosis to recidivism, adjusting for demographic and offense characteristics. Baseline externalizing disorders were associated with increased recidivism risk for both genders, whereas youths’ recidivism risk was not influenced by anxiety disorder. Girls with comorbid substance use and affective disorder were nearly four times more likely to reoffend than girls with no disorder. In contrast, among males, this disorder profile was associated with only approximately half the level of recidivism risk. Results substantiate practice guidelines that recommend comprehensive mental health assessment in juvenile justice settings and identify youths with certain mental health needs who might be well served by diversion programs.
E-Learning in Small and Medium-sized Enterprises across Europe
Authors: Admiraal Wilfried , Lockhorst Ditte
Published: January 2010

There is little doubt that e-learning has had a major impact in large companies, both in allowing the extension of training provision and in facilitating professional development activities. However, the picture is far less clear when it comes to Small and Medium Enterprises (SMEs). Technology and attitudes of managers and employees seem to form potential drawbacks to e-learning initiatives in SMEs. Questionnaire data have been gathered from more than 400 owner-managers of SMEs in 7 European countries. Furthermore, 105 owner-managers and 5 employees from 105 of these firms have been interviewed on aspects of e-learning in their company. The overall picture of e-learning in small firms across seven European countries was fairly negative: owner-managers generally did not show positive attitudes towards technology, learning and training in companies. These attitudes are strongly related to technology infrastructure in the company and vary among companies of different size and from different economic sectors.
The Nature of Reciprocity in Family Firm Succession
Authors: Janjuha-Jivraj Shaheena , Spence Laura J.
Published: January 2010

Reciprocity is a theoretical framework that has a substantial pedigree, being a recurring concept in many religions and philosophical approaches. It is also an important aspect of organizational life. Inter-generational succession in family enterprises is the most critical determinant of their long-term survival (Morris et al., 1997). Reciprocal behaviour is inherent in family relationships and thereby an important influence on relationships within family firms. By applying reciprocity theory to family firm succession, we adopt an integrated view of family firms incorporating their kinship and community contexts, as a means of understanding the dynamics between family members and hence issues affecting survival. Existing theories of reciprocity, such as moral reciprocity, mutual reciprocity, univocal reciprocity and intergenerational reciprocity, are inadequate in helping us to understand the dynamics of family firm succession. A new development of reciprocity theory is proposed resulting in a conceptual framework for family firm succession called Bounded Intergenerational Reciprocity.
Does the Relationship Between Neighborhood Socioeconomic Status and Health Outcomes Persist Into Very Old Age? A Population-Based Study
Authors: Menec Verena H. , Shooshtari Shahin , Nowicki Scott , Fournier Shari
Published: January 2010

Objective: The purpose of this article is (a) to extend previous research on the relationship between neighborhood socioeconomic status (SES) and health by considering a wide range of health-related measures derived from administrative health care records and (b) to explore whether this relationship persists into old age. Method: The study involved a complete cohort of community-dwelling residents in Winnipeg, Canada, who were 65 years or older in 2004/2005 ( N = 77,930). Health measures were derived from administrative claims data. Census data were used to derive neighborhood-level SES. Results: Multilevel logistic regressions indicated that, relative to individuals living in the most affluent areas, those in the poorest areas had significantly higher odds of having arthritis, diabetes, hypertension, congestive heart failure, ischemic heart disease, chronic obstructive pulmonary disease, depression, and stroke. Significant neighborhood income effects tended to be evident among individuals age 65 to 75 as well as those age 75+. Discussion: A wide range of health conditions among older adults are disproportionately clustered into the poorest areas. Programs and services should be designed to meet the needs of older adults of any age in such neighborhoods.
The BARI 2D study: A randomised trial of therapies for type 2 diabetes and coronary artery disease
Authors: Rutter Martin K , Nesto Richard W
Published: January 2010

The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial randomized 2368 patients with type 2 diabetes (T2DM) and coronary artery disease to either prompt revascularization or intensive medical therapy alone; and to either insulin-sensitization or insulin-provision diabetes therapy. Randomization was stratified by proposed revascularization method. Five-year survival and major cardiovascular events (MACE) were similar in study subgroups except in the coronary bypass surgery (CABG) stratum where there were fewer MACE after revascularization. There was less hypoglycaemia and weight gain, and greater apparent benefit from CABG in the insulin sensitization group. BARI 2D has provided important data for clinicians.
What Makes for a Critical Press? A Case Study of French and U.S. Immigration News Coverage
Authors: Benson Rodney
Published: January 2010

This article measures and explains criticism in U.S. and French national newspapers during the 1990s and 2000s. Criticism is operationalized in terms of discrete critical statements directed at governmental, political party, business, civil society, and foreign/ international organizations or officials; such critical statements, which take various forms—administrative, character, truth, ideology, policy, and strategy—offer a more comprehensive measure of criticism on a day-to-day basis than the occasional in-depth investigative report.While state intervention is often argued to have a censoring effect, this study finds that the more “statist” French press presents a greater density of criticisms than the U.S. press. French newspapers that receive the highest direct subsidies are not less critical of the government or dominant party than other French (or U.S.) newspapers. French newspapers exhibit a slightly higher degree of political parallelism, but in both countries newspapers tend to aim the greatest amount of criticism toward the party in power, whether Left or Right. Relatively higher French criticism is also facilitated by a distinctive French journalistic cultural form, the “debate ensemble,” that, in contrast to U.S. “dramatic narrative,” organizes the news as a clash of critical opposing viewpoints.
The Paradox of Respectability: The Limits of Indexing and Harrison Salisbury’s Coverage of the Vietnam War
Authors: Hamilton John Maxwell , Lawrence Regina G. , Cozma Raluca
Published: January 2010

In December 1966 through January 1967, Harrison Salisbury of the New York Times wrote dispatches based on a visit to Hanoi that disputed the administration’s claims that its highly accurate bombing did not hit civilian targets in North Vietnam. Administration officials, other journalists, and even his own paper challenged his reporting. Deemed unpatriotic, Salisbury was denied a Pulitzer Prize. This case study employs documents from the files of the New York Times , the CIA, and the Harrison Salisbury Papers at Columbia University, as well as content analysis of his coverage of Vietnam compared with other reporting by him that won a Pulitzer. The study shows how editorial standards of news sourcing become higher when correspondents challenge the official line. While illustrating factors that lead newspapers and reporters to index foreign news to the prevailing political consensus, it also demonstrates the limits of indexing and the conditions under which journalists may effectively challenge the official line.
Editorial: Macrophage functional phenotypes: no alternatives in dermal wound healing?
Authors: Stout Robert D
Published: January 2010

Macrophages accumulate at sites of tissue remodeling but their role and IL-4/13 dependency is unresolved.
Editorial: Acute inflammation in obesity: IL-17A in the middle of the battle
Authors: Galgani Mario , Matarese Giuseppe
Published: January 2010

Immunity and adipose cells participate in a complex network in which, during obesity, the chronic-low degree inflammatory state is also able to affect acute inflammation.
Response to letter by Bakker et al.
Authors: Warren H Shaw , Lin Tian
Published: January 2010

Reply to the letter of Drs. Bakker, Melgert, and Faas regarding our parent article.
Cognitive–behavioural therapy with children, young people and families: from individual to systemic therapy
Authors: Dummett Nicky
Published: January 2010

In recent decades there has been much interest in using cognitive–behavioural therapy (CBT) with children, young people and families. CBT is a collaborative approach, based on shared building of a hypothesis (the formulation) about causative and maintaining factors. When working with children, young people, their families and wider systems (e.g. a support network), therapy should incorporate interpersonal, family and systemic factors, together with developmental and attachment issues and phenomena more commonly expressed through other psychotherapeutic modalities. There is growing clinical experience that systemic cognitive–behavioural formulation can lead to systemic-process working on an individual, parent–child, family or wider-system basis. Formal evaluation of this approach is needed to consider where it fits among established psychotherapies in mental health work with young people and their families.
Discrimination against people with mental illness: what can psychiatrists do?
Authors: Thornicroft Graham , Rose Diana , Mehta Nisha
Published: January 2010

This article discusses the evidence that experiences of stigmatisation and discrimination among people with mental illnesses are common and may be severe. Furthermore, there are growing concerns that people with mental illness receive second-class physical healthcare. Beyond this, some aspects of psychiatric practice are reported as being insensitive, disrespectful or even disabling. We consider whether such claims are justified and what psychiatrists can do, directly and indirectly, to reduce stigma and discrimination and improve our practice.
Asperger syndrome and criminal behaviour
Authors: Dein Kalpana , Woodbury-Smith Marc
Published: January 2010

The importance of considering antisocial behaviour among people with autism-spectrum disorders is apparent from the significant number of case reports and case series describing criminal behaviour of people with a diagnosis of Asperger syndrome. The evidence so far does not support a specific association between the syndrome and criminal offending. However, a small yet significant number of offenders with autism who engage in illegal behaviour find themselves socially excluded or detained in secure provisions for prolonged periods. This article gives an overview of the scant empirical evidence relating to criminality within the context of Asperger syndrome, and offers suggestions for managing the syndrome in mentally disordered offenders.
Robust empirical data and clinical utility: the only drivers of change
Authors: Craddock Nick
Published: January 2010

We have arrived at our current descriptive classifications, with their many and varied array of categories, through the committee processes of DSM and ICD. To date, expert opinion, rather than solid science, has been the driver for change and this helps to explain the bewildering number of diagnostic categories and the fact that many patients meet criteria for several categories. Over the coming years, advances in neuroscience will offer the opportunity to base classification on robust evidence with diagnostic entities mapping more closely onto the workings of the brain. There are major shortcomings to the current classifications but all changes come at a cost to their users. We should be fully aware of the shortcomings and be thinking about the future. However, major changes to classification should await the emergence of robust empirical data and proven clinical utility. This will be the best way to benefit patients.
High- v. low-dose quetiapine in schizophrenia: meta-analysis
Authors: Painuly Nitesh
Published: January 2010

Aims and method

To study the difference between high- and low-dose quetiapine in acute treatment of schizophrenia. Data available from published double-blind fixed-dose trials were combined and analysed.

Results

There was no statistically significant difference between high- (750–800 mg/day) and low-dose (300–400 mg/day) quetiapine in terms of the response rate, change in positive symptoms score and the discontinuation rates either as a result of lack of response or adverse effects.

Clinical implications

Combined evidence from fixed-dose trials does not support the prevalent practice of targeting the higher dose of quetiapine for optimal treatment response in schizophrenia.
Failure Analysis Using Optical Evaluation Technique (OBIC) of LDs for Fiber Optical Communication
Authors: Takeshita Tatsuya , Oohashi Hiromi
Published: January 2010

The introduction of high-speed services for fiber-optic access subscribers has led to a huge growth in data traffic. The rapid diversification of services means that next generation networks must be built quickly, economically and reliably.

A high temperature laser allows us to eliminate the thermo-electric cooler conventionally needed in a transmitter module, which results in reductions in cost, power consumption and size. Moreover, a high-power laser provides a wide tolerance when coupling optical fibers. In addition, a high-power pump laser is needed to realize a wide-band and high-power erbium-doped fiber amplifier. This makes high-performance laser chips one of the keys to achieving highly reliable and cost-effective systems.

In terms of laser reliability, we must clarify the degradation mechanism and postpone or suppress degradation if we are to achieve a reliable high-performance laser. We have analyzed degraded lasers using the optical beam induced current (OBIC) technique. When there are nonradiative recombination centers in the degraded region, the OBIC intensity decreases with increases in recombination density. This technique has the advantages of being non-destructive and highly sensitive. In addition, it provides high space resolution in degradation analyses.

The OBIC is measured through the window of a transistor outline (TO) can before and after aging. Then, by using the same LDs we can detect an OBIC change for several aging times. We can both detect the degraded region and layer, and estimate the degree of laser degradation by employing the relative OBIC intensity prior to aging. This OBIC technique is useful for analyzing the degree of laser degradation.

Moreover, the incident wavelength can be changed by changing the optical source in the OBIC measurement setup, which in turn changes the absorption layer and the penetration distance. Some degraded laser layers are reveled by using these several wavelengths absorbed in different layers. In addition, degradation in the waveguide interior is detected by using an incident wavelength with long penetration. Thus, by monitoring the OBIC intensity at several wavelengths as well as before and after aging, we are able to discuss sudden and wear-out laser failures. In our presentation, we will introduce examples using the OBIC technique that contributed to the improvement of laser reliability.
Observation of Dopant Profile of Transistors Using Scanning Nonlinear Dielectric Microscopy
Authors: Honda Koichiro , Cho Yasuo
Published: January 2010

We have demonstrated that scanning nonlinear dielectric microscopy (SNDM) exhibited high performance and high resolution in observing the dopant concentration profile of transistors. In this study, good quantitative agreement between the SNDM signals and dopant density values obtained by SIMS in standard Si samples, which dopant concentrations have been calibrated. We succeeded in visualizing high-resolution dopant profiles in n- and p-type MOSFET with 40 nm gate channels. It is considered that SNDM would be an effective method in measuring the quantitative two-dimensional dopant profiles of transistors. Finally, we have succeeded in detecting the dopant profiles of SRAM memory cell transistors.
Electrical and Optical Properties of CVT-grown ZnO Crystals
Authors: Abe Koji , Oiwa Masanori
Published: January 2010

Effects of H2O partial pressure on ZnO crystal growth by chemical vapor transport (CVT) have been investigated. The use of H2O causes the increase in growth rate of ZnO, indicating that H2O acts as a dominant oxygen source in ZnO growth by CVT. The use of H2O also improves structural, electrical, and optical properties of the CVT-grown ZnO crystals. A sharp X-ray rocking curve for the ZnO (0002) reflection was obtained, and the full width at half maximum value was 38 arcsec. Strong near band edge emission was observed in photoluminescence spectra at room temperature. Both carrier concentration and Hall mobility increased with partial pressure of H2O. The dependence of the carrier concentration on temperature indicates that there exist two donors in the CVT-grown ZnO crystals. The estimated ionization energy for the shallow donor was 35±5 meV and that for the deep donor was 115±5 meV.
Traps and Defects in AlGaN-GaN High Electron Mobility Transistors on Semi-Insulating SiC Substrates
Authors: Sin Yongkun , Deionno Erica , Foran Brendan , Presser Nathan
Published: January 2010

High electron mobility transistors (HEMTs) based on AlGaN-GaN hetero-structures are promising for high power, high speed, and high temperature operation. Especially, AlGaN-GaN HEMTs grown on semi-insulating (SI) SiC substrates are the most promising for both military and commercial applications. High performance characteristics from these devices are possible in part due to the presence of high two-dimensional electron gas charge sheet density maintaining a high Hall mobility at the AlGaN barrier-GaN buffer hetero-interface and in part due to high thermal conductivity of the SiC substrates. However, long-term reliability of these devices still remains a major concern because of the large number of traps and defects present both in the bulk as well as at the surface leading to undesirable characteristics including current collapse. We report on the study of traps and defects in two MOCVD-grown structures: Al0.27Ga0.73N HEMTs on SI SiC substrates and Al0.27Ga0.73N Schottky diodes on conducting SiC substrates. Our HEMT structures consisting of undoped AlGaN barrier and GaN buffer layers grown on an AlN nucleation layer show a charge sheet density of ∼1013/cm2 and a Hall mobility of ∼1500cm2/V·sec. Deep level transient spectroscopy (DLTS) was employed to study traps in AlGaN Schottky diodes and HEMTs fabricated with different Schottky contacts consisting of Pt/Au and Ni/Au. Focused ion beam was employed to prepare both cross-sectional and plan view TEM samples for defect analysis using a high resolution TEM.
Size Reduction and Rare Earth Doping of GaN Powders through Ball Milling
Authors: Guo Xiaomei , Thomas Tiju , Li Kewen Kevin , Qi Jifa , Wang Yangyun , Chen Xuesheng , Zhang Jingwen , Spencer Michael G. , Zhao Hua , Zou Yingyin Kevin , Jiang Hua , Di Bartolo Baldassare
Published: January 2010

Ball milling of ammonothermally synthesized GaN powders was performed in an ethanol solution for a variety of durations, resulting in average particle sizes of nanometer. The ball milled powders showed an obviously brightened color and improved dispersability, indicating reduced levels of aggregation. X-ray diffraction (XRD) peaks of the ball milled GaN powders were significantly broadened compared to those of the as-synthesized powders. The broadening of the XRD peaks was partially attributed to the reduction in the average particle size, which was confirmed through SEM analyses. On the other hand, rare earth doping of commercial GaN powders was also achieved through a ball mill assisted solid state reaction process. Rare earth salts were mixed with GaN powder by ball milling. The as-milled powders were heat treated under different conditions to facilitate the dopant diffusion. Luminescence properties of the rare earth doped GaN powders at near infrared range were investigated and the results were discussed.
Short period p-type AlN/AlGaN superlattices for deep UV light emitters
Authors: Nikishin Sergey A. , Borisov Boris , Mansurov Vladimir , Pandikunta Mahesh , Chary Indra , Rajanna Gautam , Bernussi Ayrton , Kudriavtsev Yuriy , Asomoza Rene , Bulashevich Kirill , Karpov Sergey Yu. , Sohal Sandeep , Holtz Mark
Published: January 2010

The Mg doped AlN/AlxGa1-xN (0.03 ≤ x ≤ 0.05) short period superlattices (SPSLs) were grown by gas source molecular beam epitaxy on (0001) sapphire substrates. The average AlN mole fraction is ∼ 0.7 and the hole concentration is ∼ 7×1017 cm-3. Contacts formed to the SPSLs using Ni/Au bilayer are found to have specific contact resistance ∼ 5×10-5 Ωcm2 near room temperature and to show weak temperature dependence attributed to activation of Mg acceptors in the AlN barriers of SPSLs. These p-SPSLs are attractive for fabrication of transparent low resistive ohmic contacts for deep UV LEDs.
THz Emission from InN
Authors: Ahn Hyeyoung , Yeh Yi-Jou , Hong Yu-Liang , Gwo Shangjr
Published: January 2010

We report the terahertz (THz) emission from the wurzite indium nitride (InN) films grown by molecular beam epitaxy (MBE). More than two orders of magnitude of THz power enhancement has been achieved from the InN film grown along the a-axis and magnesium (Mg) doped InN with a critical carrier concentration. The primary radiation mechanism of the a-plane InN film is found to be due to the acceleration of photoexcited carriers under the polarization-induced in-plane electric field perpendicular to the a-axis. Apparent azimuthal angle dependences of THz wave amplitude and the second harmonic generation are observed from a-plane InN. In the Mg-doped films, Mg as the acceptors compensate the native donors in the InN films and large band bending over a wider space-charge region causes the enhancement of THz emission power compared to the undoped InN.
Molecular dynamics of carbon nanobearings
Authors: Shintani K. , Arai N. , Shintani K.
Published: January 2010

A concept of nanoscale bearing structures utilizing nanocarbon materials is presented based on the prediction via molecular dynamics simulations. The proposed mechanism consists of a graphene layer, intercalated single walled carbon nanotubes (SWNTs), and substrate graphenes. It is found that the friction against the movement of the uppermost graphene is smallest for the 1 SWNT model.
Suppression of Inelastic Deformation in Multilayer Microcantilevers with Nanoscale Coating
Authors: Lin I-Kuan , Zhang Xin , Zhang Yanhang
Published: January 2010

Multilayer microcantilevers present in micro-/nano- electromechanical system (MEMS/NEMS) applications serving passive and active structural roles. The application and commercialization of MEMS devices suffer from reliability problems. Appropriate nanocoatings, such as atomic layer deposition (ALD), have been demonstrated to be promising solutions for these reliability problems in MEMS devices. However, the micro/nano- mechanics within and/or between the microcantilevers and nanocoatings are not fully understood, especially when temperature, time, microstructural evolution and material nonlinearities play significant roles in thermomechanical response. The overall goal of this work is to suppress and understand the inelastic deformation and microstructural evolution in multilayer microcantilevers with nanocoatings. Moreover, to better understand the stress relief and Al2O3 suppression mechanism, scanning electron microscopy (SEM) was employed to explore the microstructural evolution.