bluuebunny/crossref_metadata_2025 huggingface dataset:
Physics of Nanostructure Design for Infrared Detectors
Authors: Kumar Dhar Nibir , Ganguly Samiran , Krishnamurthy Srini
Published: December 2021

Infrared detectors and focal plane array technologies are becoming ubiquitous in military, but are limited in the commercial sectors. The widespread commercial use of this technology is lacking because of the high cost and large size, weight and power. Most of these detectors require cryogenic cooling to minimize thermally generated dark currents, causing the size, weight, power and cost to increase significantly. Approaches using very thin detector design can minimize thermally generated dark current, but at a cost of lower absorption efficiency. There are emerging technologies in nanostructured material designs such as metasurfaces that can allow for increased photon absorption in a thin detector architecture. Ultra-thin and low-dimensional absorber materials may also provide unique engineering opportunities in detector design. This chapter discusses the physics and opportunities to increase the operating temperature using such techniques.
Biosimilar Monoclonal Antibodies in Latin America
Authors: Karp Paola , Gatto Matías , Victoria Batto María , Ferrero Sol , Helguera Gustavo
Published: December 2021

In the last decade, the expiration of patents protecting therapeutic monoclonal antibodies opened an opportunity for the development and approval of biosimilar versions of these drugs. The complexity of these biologic molecules required the imposition of strict regulations to establish robust comparability with the antibody of reference in physicochemical, analytical, biological and, when deemed necessary, clinical data. Accordingly, this period coincides with the updating of the requirements and guidelines for the manufacture and approval of biologics in Latin American countries by their respective regulatory agencies. Although the term “biosimilar” does not appear in the official regulatory provisions in most of the countries, it is of general use in Latin America, and several biosimilars of therapeutic monoclonal antibodies were approved based on comparative quality, nonclinical and clinical data that demonstrate similarity to a licensed biological reference registered before in a Regulatory Health Authority of reference. Here, we provide an overview of how the complexities of therapeutic monoclonal antibodies shaped the regulatory landscape of similar biologics, the current status of biosimilar monoclonal antibodies in Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, México, Paraguay, Perú and Uruguay and their potential to reduce the cost of antibody therapies in this region.
A Review of Progesterone Effects on Human Melanoma Cell Growth In-Vitro
Authors: Ramaraj Pandurangan
Published: December 2021

Progesterone, a female sex hormone not only has a role in reproduction, but also in protecting females in melanoma. A survey of steroid hormones actions steroid hormones actions survey on melanoma cells and literature survey showed that progesterone inhibited mouse and human melanoma cell growth significantly in-vitro. Progesterone not only inhibited cell growth, but also affected adhesion and migration functions (essential for metastasis) in-vitro. This observation correlated with the clinical studies where they had shown showed an increased survival and delayed metastasis in menstruating females in melanoma. Further, progesterone level in menstruating females (1000–1500 ng/dL) compared to post-menopausal females (20–100 ng/dL) also correlated with previous clinical studies. Progesterone action on melanoma cells, as reported by other researchers also supported the findings from this lab. Hence, progesterone could be the steroid hormone protecting menstruating females in melanoma. Moreover, our recent studies showed that progesterone suppressed pro-inflammatory cytokine IL-8 secretion by the melanoma cells, which decreased melanoma cell growth in-vitro. Hence, progesterone apart from reproductive function may also be involved in protecting menstruating females in melanoma.
Immunotherapy against Gliomas
Authors: Sebastian Mathew , DiVita Dean Bayli , T. Flores Catherine
Published: December 2021

Immunotherapy has been demonstrably effective against various cancers, particularly those in the hematopoietic system and those with a high tumor-specific antigenic burden. Unfortunately, the development of immunotherapeutic strategies has proven more challenging against central nervous system (CNS) malignancies due to several unique characteristics of brain tumors that pose extraordinary barriers. To date, there is a lack of phase III trials demonstrating improved progression-free survival (PFS) and/or overall survival (OS) using immunotherapies in brain cancers. However, a better mechanistic understanding of current resistance to immunotherapies along with data from novel innovative techniques to overcome these barriers has been encouraging. This chapter gives an overview of current immunotherapies in the development of brain cancers. We will evaluate the present studies available in the clinical setting and any of their potential findings. The chapter will also discuss pertinent preclinical strategies whose translation for human use would potentially prove efficacious or provide invaluable scientific discovery.
Aflatoxin and Disruption of Energy Metabolism
Authors: Segun James Adewale , Ifeanyichukwu Ugwor Emmanuel , Ayomide Adebiyi Victoria , Obinna Ezenandu Emmanuel , Chukwudalu Ugbaja Victory
Published: December 2021

Aflatoxins constitute a cluster of mycotoxins that are derived from fungal metabolites and are produced from diverse fungi species, especially Aspergillus. They are a collection of closely linked heterocyclic compounds produced predominantly by two filamentous fungi, Aspergillus flavus and Aspergillus parasiticus. They are also known to cause severe health threats to humans and animals, thereby resulting to several complications like immunotoxicity, teratogenicity hepatotoxicity. Aflatoxins interfere with normal metabolic processes. This interference encompasses the regulatory processes that occur throughout the progression of energy metabolism. Thus, the effects of aflatoxins are seen in the inhibition of ATP generation, carbohydrate and lipid metabolism, mitochondrial structure and proteins synthesis. This chapter will focus on the mechanisms of aflatoxin-induced disruption of lipids, carbohydrates, and proteins metabolism, and how they affect the bioenergetic systems.
Control of Clinical Laboratory Errors by FMEA Model
Authors: Sabati Hoda , Mohsenzadeh Amin , Khelghati Nooshin
Published: December 2021

Patient safety is an aim for clinical applications and is a fundamental principle of healthcare and quality management. The main global health organizations have incorporated patient safety in their review of work practices. The data provided by the medical laboratories have a direct impact on patient safety and a fault in any of processes such as strategic, operational and support, could affect it. To provide appreciate and reliable data to the physicians, it is important to emphasize the need to design risk management plan in the laboratory. Failure Mode and Effect Analysis (FMEA) is an efficient technique for error detection and reduction. Technical Committee of the International Organization for Standardization (ISO) licensed a technical specification for medical laboratories suggesting FMEA as a method for prospective risk analysis of high-risk processes. FMEA model helps to identify quality failures, their effects and risks with their reduction/elimination, which depends on severity, probability and detection. Applying FMEA in clinical approaches can lead to a significant reduction of the risk priority number (RPN).
Goat’s Milk (GM), a Booster to Human Immune System against Diseases
Authors: Panta Rajendra , Kumar Paswan Vinod , Kumar Gupta Pankaj , Narayan Kohar Dhruba
Published: December 2021

Milk is clean lacteal secretion from mammalians shortly after parturition. GM is taken as a complete meal in human diet. GM is the only milk from milching species that possess possibility of substituting human milk. Availability of A2 casein in GM make it comparable to human milk in terms of protein. The most vulnerable ones are infants, aged people and pregnant women as their immune system could answer at any time if extra supplement is not administered. In this case, GM is only option that is highly compatible and nutritious nourishing food naturally. It has been used in curing respiratory problems, diarrhoea, colic, gastrointestinal disturbances etc. Feeding GM enhances production of immunoglobulin, beneficial gut microbiota, phagocytosis activities. Presence of inherent antibodies suits GM for using it in curing Tuberculosis. It contains every needed nutrient in higher amount as compared to milk from other animals. Per servings it has 13% more Calcium, 47% more vitamin A than Cow’s milk. It is filled with most of the trace minerals. Selenium, an immune system enhancer provides anti-oxidative and anti-inflammatory protection via inhibition of bacterial growth. Chlorine and Fluorine acts as natural germicides. GM contain good source of Potassium which is crucial for maintainance of blood pressure and functioning of heart, it protects against arteriosclerosis. GM not only reduces the level of total cholesterol due to presence of Medium Chain Triglycerides but also improve mineralisation of skeleton and haemoglobin level. GM consists huge source of biorganic sodium, the absence of which results in arthritis. People who are lactose intolerant even can consume GM as it has low lactose content and for those who finds its smell and taste unusual, there is option of fortification. Because of easily digestible and readily bioavailable nature its consumption has been increased.
Effect of Biotic and Abiotic Stresses on Plant Metabolic Pathways
Authors: Banothu Venkanna , Uma Addepally
Published: December 2021

Plants are prone to encounter some environmental stresses that include both biotic and abiotic. Plants in response to these stress conditions alter their metabolism at the genetic level with consequential effects at the metabolite production. Phenolic compounds, which are secondary metabolites are one such chemical entity which plays a significant role in various physiological processes of the plant. They are mainly formed by three different types of metabolic pathways that produce phenyl propanoid derivatives, flavonoids, terpenoids based on the needs of the plant and the rate of their production is solely dictated by the type of stress condition. A number of phenolic compounds like phytoalexins, phytoanticipins and nematicides exhibit negative response to biotic stress against several soil borne pathogens and nematodes. But some of the phenolic compounds like acetosyringone, umbelliferone, vanillyl alcohol, p-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, apigenin and luteolin are found to exhibit beneficial effects to plants by encouraging rhizosphere formation particularly in Leguminosae family. Some of the ROS produced in various stress conditions are effectively dealt by various phenolics with antioxidant activity like hydroxyl benzoic acids and hydroxyl cinnamic acids. As the in vivo production of phenolics in plants is influenced by external factors it can certainly provide information for the adoption of agronomic practices to yield the full befits of commercial exploitation. As the in vivo production of phenolics in plants is influenced by external factors it can certainly provide information for the adoption of agronomic practices to yield the full befits of commercial exploitation.
Relationship Between Platelet to White Blood Cell Ratio and 30-Day Prognosis of Patients with Acute-on-Chronic Liver Failure
Authors: Xu Xiang , Li Chen , Chen Jing , Liu Xiaoyan , Su Haibin , Tong Jingjing , Hu Jinhua
Published: December 2021

Background: Acute-on-chronic liver failure (ACLF) is always associated with thrombocytopenia or leukocytosis. Therefor the platelet to white blood cell ratio (PWR) in ACLF patients is always reduced. Objectives: Here, we assessed the relationship between PWR and prognosis in ACLF patients. Methods: A retrospective cohort of 415 patients, including 100 patients that were diagnosed of chronic hepatitis B, 104 patients suffered of HBV-related liver cirrhosis and 211 patients suffered of HBV-related ACLF, was investigated. Univariate and multivariate COX models were used to investigate the relationship between PWR and 30-day survival in patients with ACLF. Factors affecting PWR in ACLF patients were also analysed using logistic regression analysis. Results: At baseline, the platelet count in patients with HBV-related ACLF was significantly lower than that in patients with CHB and patients suffered of HBV-related cirrhosis. The PWR value was much higher in the survivors of ACLF than in ACLF patients who died. PWR, age, total bilirubine, prothrombin activity, and aspartate transaminase were independent predictors of the 30-day survival rate of ACLF patients. We also found that ascites and infection were independent factors related to the decrease of PWR in ACLF patients. Conclusions: The PWR value was significant declined in ACLF patients. And it was independent risk factors for the survival rate of those patients.
Predicting High-risk Behaviors Based on Time Perspective in Iranian Adolescents by Emphasizing the Mediating Role of Decision Making and Inhibitory Response: Path Analysis
Authors: Bagherian Fatemeh , Mozafari Nazir , Zadeh Mohammadi Ali , Heidari Mahmood
Published: December 2021

Background: Adolescence is defined as a period with multiple and intertwined physical, psychological, and social developments during which risky behaviors increases. Various factors affect the tendency and occurrence of risky behaviors. Time perspective (TP) is defined as the role of time and attitude toward time in affairs and behaviors. Executive functioning skills allow an individual to perceive stimuli from his or her environment, respond adaptively, flexibly change direction, anticipate future goals, consider consequences, and respond in an integrated or commonsense way. Objectives: This study aimed to predict risky behaviors based on TP in Iranian adolescents by emphasizing the mediating role of decision making and inhibitory response. Materials and Methods: Path analysis was used to evaluate the relationship between components of TP and risky behaviors with mediator variables, decision making, and inhibitory response among 804 high school adolescent students (including 470 males and 334 females) in Sanandaj, Iran. All participants were asked to complete the Iranian Adolescent Risk Scale and Time Perspective Scale and perform 2 computer tasks [i.e., Go/No-Go and Balloon Analogue Risk Task (BART)]. Statistical methods were descriptive statistics, correlation test, as well as path analysis. Also, the bootstrapping procedure was used. The output provided a 95% CI of the indirect effects. SPSS version 26 and AMOS version 24 were used to analyze direct and indirect relationships. Results: There was a significant relationship between the components of TP and the tendency to risky behaviors. Risky decision-making and inhibitory response had a significant effect on 3 aspects of TP in predicting adolescents’ risky behaviors. These effects were both direct and indirect, of which the former effect was created by mediating the decision-making and inhibitory response. Conclusions: The components of TP, decision-making, and inhibitory response predict risky behaviors in adolescents.
Utilization of Preventive Care Services at a University Hospital in Saudi Arabia
Authors: Al-Ghamdi Mohammed Ali , Al-Raddadi Rajaa M , Althomali Omar W , Bazaid Abdulrahman S
Published: December 2021

Background: Chronic diseases have significant impacts on health systems worldwide and are a leading cause of death. Early diagnosis and treatment of chronic diseases are the best ways to reduce mortality and morbidity. Objectives: The aim of this study was to evaluate public access to preventive services for chronic diseases in Jeddah, Saudi Arabia. Methods: A survey of university hospital visitors was conducted in 2019. Participants were randomly selected and asked to fill a 16-question survey, including demographics, health care utilization, and type of preventive services. The chi-square test (SPSS) was used to identify any significant association between age and gender using the variable of preventive screening or counseling. Results: The majority of individuals who completed the survey (250 participants) were young, married, and male bachelor’s degree holders. About 71% of the participants received counseling services for either smoking, physical activity, weight, diet, or sleeping. More than half (58%) had undergone screening services, including breast cancer, colon cancer, diabetes, hypertension, or weight management. Chi-square analysis showed that females had a significant (P < 0.01) positive statistical relationship with the utilization of diabetes and breast cancer screening services, while males were more associated (P < 0.01) with smoking and weight-related counseling than females. Conclusions: The study demonstrated an insufficient use of preventive services and that sociodemographic differences (such as age and gender) could influence the utilization of various preventive services. Females were significantly positively associated with breast cancer and diabetes-related preventive services as these diseases are highly prevalent among females. Public education and awareness campaigns are needed to broadcast the importance of preventive services and promote better understanding and management of chronic diseases.
Philosophical Peace and Methodological Nonviolence
Authors: Fiala Andrew ,   Eastern Illinois University
Published: December 2021

This article considers the nonviolent commitment of philosophy, arguing that “methodological nonviolence” is a normative ideal guiding philosophical practice and that rational dialogue is connected with nonviolence. The paper presents a transcendental argument about the form of nonviolent communication. Even when philosophers argue in favor of justified violence, they make such arguments within a nonviolent practice. The argument is grounded in historical references to ways that philosophers have clarified the philosophical commitment to methodological nonviolence, the ideal unity of means and ends, and the ideal community of inquiry, which is a model of positive peace. While Socrates is treated as a paradigmatic example of methodological nonviolence, Tolstoy’s work is presented as a crucial historical turning point from implicit methodological nonviolence to the more explicit forms that may be found in the works of Jane Addams, Mohandas K. Gandhi, and Martin Luther King, Jr.
Heterotopias teatrais e a concepção de energia – Suzuki e a cena contemporânea japonesa
Authors: Raquel Fernanda , Greiner Christine
Published: December 2021

Quando foi criada a SITI Company (1992) por Anne Bogart e Tadashi Suzuki, tornou-se comum falar no método Suzuki-Viewpoints. Porém, alguns artistas mais jovens desconhecem a produção destes grandes pesquisadores, antes da parceria. O objetivo deste artigo é apresentar algumas características dos primórdios do que foi considerado o treinamento Suzuki em 1965, quando criou o Waseda Shogekijo (Pequeno Teatro de Waseda), até a chegada de sua companhia em Toga. A proposta não é reconstituir a sua biografia, mas investigar o que segue em movimento do pensamento/ação de Suzuki, como a invenção de heterotopias teatrais que afetam, de modos diferentes, a cena contemporânea japonesa, e a sua noção singular de energia como tecnologia de comunicação.
Contagiar sonhos e resistências: A casa, a tela e o entre
Authors: Reis Bruna Martins , Rabelo Flavio , Silva Dora de Andrade , Rezende Carlos Roberto Cavalcante de
Published: December 2021

Este artigo aborda alguns aspectos criativos e pedagógicos da experiência da oficina "Só os sonhos não temem o contágio", realizada pelo Núcleo Fuga! de forma online no contexto da pandemia COVID 19. No que se refere ao estudo da presença neste modo remoto, exploramos algumas propostas acionadas pelas ideias de contágio e pertencimento, em uma prática apoiada na Técnica Klauss Vianna de dança e educação somática e em programas performativos, articulados à práticas cartográficas. No estudo criativo das composições com o ambiente da casa, as proposições visavam escavar possibilidades performativas ao se visitar as imagens-enigmas dos sonhos, como tensionamento para provocar a relação entre arte, inconsciente e resistência.
A primeira Caixa Econômica da Bahia: Gênese e atividades iniciais (1834-1850)
Authors: Fagundes da Silva dos Santos Augusto
Published: December 2021

Este artículo tiene como objetivo principal presentar el contexto de creación y las características operativas de la Primera Caja de Ahorros da Bahía, entre los años 1834 y 1850. El texto está organizado en tres partes, además de la introducción y las consideraciones finales. En la primera parte del artículo, revisamos los principales trabajos sobre las Cajas de Ahorros brasileñas en el siglo XIX. En la segunda parte, abordamos las características operativas de la institución y los principales tipos de inversión. Y en la tercera y última parte, mostramos la evolución del capital y el número de accionistas de la Caja Privada da Bahía, destacando el alto grado de concentración de las pólizas de unas pocas personas.

This article has as main objective to present the creation context and the operating characteristics of the First Savings Banks of Bahia, between the years 1834 and 1850. The text is organized in three parts, in addition to the introduction and the final considerations. In the first part of the article, we survey the main works on the Brazilian Savings Banks in the 19th century. In the second part, we address the institution’s operating characteristics and main types of investment. And in the third and last part, we show the evolution of capital and the number of shareholders Savings Banks of Bahia, highlighting the high degree of concentration of policies held by a few individuals.
EL CONCEPTO DE SMART DESTINATION EN LA INVESTIGACIÓN TURÍSTICA. REVISIÓN SISTEMÁTICA DE LA LITERATURA PARA SU DEFINICIÓN Y NORMALIZACIÓN
Authors: Carballido Ainhoa , Guevara Plaza Antonio
Published: December 2021

Con el auge del uso de las Tecnologías de la Información y la Comunicación (TIC) y un nuevo escenario en el que las zonas urbanas se superponen a las áreas rurales en términos de volumen poblacional, nuevas necesidades emergen, y con ellas nuevos modelos urbanos y económicos como lo son las Smart Cities, las Smart Destinations, o el Smart Tourism. Este artículo trata de establecer una definición holística de estos términos, profundizando en el modelo de inteligencia aplicado al destino turístico, a través de una revisión literaria que permitirá esclarecer los inicios, la evolución y la situación actual de estos conceptos.

With the use of the Information and Communication Technologies (ICT) boom and a new scenario in which urban areas are beyond rural ones in terms of demographic size, new needs emerged, and with them new urban and economic models, such as Smart Cities, Smart Destinations, or Smart Tourism. This paper aims to establish a holistic definition of those concepts, deepening in the smartness model applied to a tourism destination, through a literature review that allows clarifying the beginning, the evolution, and the current situation of those concepts.
ESPACIOS NATURALES PROTEGIDOS, RETO DEMOGRÁFICO Y TURISMO.EL EJEMPLO DE LA RESERVA DE LA BIOSFERA Y PARQUE NACIONAL DE MONFRAGÜE (EXTREMADURA, ESPAÑA)
Authors: Leco Berrocal Felipe , Mateos Rodríguez Ana Beatriz
Published: December 2021

Los espacios naturales protegidos son uno de los recursos más demandados desde el punto de vista turístico. Esta investigación analiza las relaciones causa-efecto que ha tenido la declaración de Monfragüe como Reserva de la Biosfera y Parque Nacional en el comportamiento demográfico, económico y turístico del territorio que comprende. Desde una metodología cualitativa, apoyado en el análisis de fuentes estadísticas, se concluye que las expectativas depositadas en el turismo no han conseguido frenar la despoblación ni potenciar la diversificación económica.

Protected natural areas are one of the most demanded resources from the tourist point of view. This research analyses the cause-effect relationships that the declaration of Monfragüe as a Biosphere Reserve and National Park has had on the demographic, economic and tourist behaviour of the territory it encompasses. From a qualitative methodology, supported by the analysis of statistical sources, it is concluded that the expectations placed in tourism have not managed to halt depopulation or promote economic diversification.
La actuación de los ayuntamientos frente a la elaboración de materiales didácticos
Authors: Álvarez-Seoane Denébola , Rodríguez Rodríguez Jesús , Muñoz Moreno José Luis
Published: December 2021

La elaboración de materiales didácticos por parte de los Ayuntamientos representa una concreción relevante en la perspectiva de la implicación y la participación de los municipios en la educación. El estudio que aquí se desarrolla ha tenido el objetivo de analizar las características de los materiales didácticos y sus procesos de elaboración por parte de los Ayuntamientos de la provincia de A Coruña (Galicia - España) y, particularmente, indaga en las buenas prácticas de los municipios de A Coruña, Cabana de Bergantiños y Santiago de Compostela. La metodología seguida ha considerado la revisión documental, la evaluación y catalogación de materiales didácticos y la visión de los responsables municipales. Los principales resultados obtenidos profundizan en las dimensiones de la caracterización de los materiales didácticos, así como de su planificación, diseño, publicación y difusión. Entre las conclusiones alcanzadas se destaca que el diseño y desarrollo de materiales didácticos por parte de los Ayuntamientos tiene múltiples posibilidades y responde a necesidades bien distintas en una realidad municipal diversa.
Quels impacts de l’aide financière sur la performance des établissements manufacturiers en région non-métropolitaines ? Une réponse par méthode d’appariement spatial
Authors: Belleau-Arsenault Catherine , Dubé Jean
Published: December 2021

L’allocation d’aides financières gouvernementales soulève toujours un certain débat. Est-ce que les aides financières ont un réel impact sur la performance des entreprises ? Cet article s’intéresse aux impacts de l’aide financière sur la performance des entreprises manufacturières en région non-métropolitaine (Bas-St-Laurent, Québec, Canada). La performance est mesurée sous deux angles distincts, mais complémentaires : i) la survie des établissements et ii) la croissance de l’emploi. Une analyse par méthode d’appariement (matching), basée sur les caractéristiques individuelles et les caractéristiques du voisinage, permet d’isoler l’effet des aides à partir d’une riche base de micro-données portant sur l’ensemble des établissements actifs sur le territoire du Bas-Saint-Laurent entre 2006 et 2015. Les résultats montrent que les aides financières gouvernementales ont un effet positif sur la croissance de l’emploi des établissements ainsi que sur la survie des établissements.
La citoyenneté démocratique des enfants à l’école primaire
Authors: Boyer Stéphanie , Gaudet Stéphanie
Published: December 2021

Cet article analyse les représentations sociales de la citoyenneté des enfants qu’ont des enseignant⋅e⋅s québécois⋅es du primaire engagé⋅e⋅s dans l’éducation à la citoyenneté démocratique des jeunes. À partir de leurs récits de pratique, nous analysons comment elles⋅ils construisent une représentation sociale de la citoyenneté des enfants différenciée de celle des adultes. À partir des thèmes émergeant des entrevues, nous avons identifié les dimensions à partir desquelles elles⋅ils se représentent la citoyenneté des enfants. Les dimensions du rôle de l’école, de l’autorité des adultes, de la socialisation par les pair⋅e⋅s, de l’agentivité politique des enfants et du changement social ont émergé des entretiens et donnent sens à la représentation qu’elles⋅ils se font de l’enfant et de sa place dans la société démocratique. Cet article contribue aux connaissances en sociologie de l’enfance et à ses applications en éducation à la citoyenneté démocratique.
Réflexion sur la criminalisation de l’inceste et ses justifications : au-delà du tabou universel
Authors: Robert Marie-Pierre
Published: December 2021

Le présent texte analyse le crime d’inceste en droit canadien à deux niveaux. Tout d’abord, en s’appuyant sur la législation et la jurisprudence, l’auteure en étudie la définition et les éléments constitutifs afin de bien le saisir. Ensuite, elle s’intéresse aux théories de la criminalisation en considérant les justifications avancées pour soutenir la criminalisation de l’inceste. Pourquoi le criminalise-t-on, notamment entre adultes consentants ? L’acceptabilité de ces justifications, dans le contexte social actuel et compte tenu des droits et libertés, est examinée, de même que l’inadéquation entre le cadre normatif, d’une part, et les justifications avancées pour le soutenir, d’autre part. En particulier, le dégoût comme fondement de la criminalisation et les dangers que cela comporte sont traités. Bref, l’auteure remet en question les contours de l’infraction d’inceste, plus précisément dans son application aux adultes consentants.
An Evaluation Model for Foreign Direct Investment Performance of Free Trade Port Zones
Authors: Hsu Wen-Kai K. , Huang Show-Hui S. , Huynh Nguyen Tan
Published: December 2021

With the tendency of internationalisation and globalisation, signing regional economic agreements among multiple countries has become a trend. Under such an integration environment, some free economic zones with port transportation functions have become crucial for FDI (foreign direct investment) investors in selecting investment locations. The free trade port zone (FTPZ) is argued to be one of the most well-known. This paper aims to assess the FDI performance of FTPZs. On the basis of the FTPZ's features and relevant literature, assessment criteria (ACs) are initially identified. An evaluation model based on the fuzzy AHP (Analytic Hierarchy Process) approach is then introduced to evaluate the FTPZs' FDI performance from foreign investors' viewpoints. Finally, the FTPZ of the Kaohsiung port in Taiwan was empirically investigated to verify the assessment model. Results point out that for the FTPZ of Kaohsiung port, ACs with higher priorities needing improvement are raw material acquired, local government efficiency, and political stability and social security. Theoretical and practical recommendations for the FTPZ managers are discussed based on the results.
Major Barriers in Adoption of Electric Trucks in Logistics System
Authors: Qasim Muhammad , Csiszar Csaba
Published: December 2021

The article analyses the issues concerning the reluctance of logistics professionals to adopt medium-sized electric trucks (ET) in the logistics system. Logistics trucks are oversized polluters, considered to be one of the hardest to be addressed for the reduction of CO2 emissions. It aims to identify the major barriers hindering the spread of ETs in logistics. The total cost of ownership (TCO) comparison between a traditional and electric truck has revealed the price gap at the end of a useful lifecycle is marginal. Incentivisation can bridge the gap. This research was based on a survey conducted among professionals from the logistics field in Budapest. Responses recorded were analysed by descriptive statistics to identify highly-rated barriers and their priorities. Based on the results, recommendations were suggested to facilitate the adoption of ETs.
Kajian Terhadap Naskah Kuna Nusantara Koleksi Fakultas Ilmu Pengetahuan Budaya Universitas Indonesia: Penyakit dan Pengobatan Ramuan Tradisional
Authors: Nawangningrum Dina , Widodo Supriyanto , Suparta I Made , Holil Munawar
Published: December 2021

From the manuscript, we can take the information about deseases and the medical treatment. The study of nusantara’s manuscripts which keep on the library Faculty of Humanities University of Indonesia (before Faculty of Letters-UI), especially medical text Javanese, Balinese, Melanese, and Sundanese show the information about the deseases, varieties of herba medical, processing, and therapies.
Seni Gerak dalam Pertunjukan Wayang Tinjauan Estetika
Authors: Darmoko Darmoko
Published: December 2021

Movement art in the puppet performances is often mentioned as sabetan. Puppet movement art, that contains rules, norms, guidance (orientation) is convention that is observed and referred to guidance the dalang artists when they move the puppets. One of the convention of movement in the puppet performance is udanagara. Udanegara, that contains ethics and aesthetic, is the rules of speaking, attitude, and action for actors in the puppet performance. Puppet movement include among others paying homage, walking, running, dancing, flying and fighting. That puppet movement is based on social class of puppet, age of puppet, class of puppet, and mood of expression of puppet. Therefore, the movement art of the puppet adopts basic wiraga (true or false action in the puppet movement), wirasa (true or false feeling of puppet movement), and wirama (true or false rhythm in the puppet movement). Method in this research will be conducted step by step: collection data (to watch of puppet performance on television, live performance, dialogue with dalang artist), analysis of data, literary research, conclusion and reporting of the research. This research concludes: puppet movement has of two meanings, large (totality of puppet movement) and narrow (fighting); puppet movement refers to the conventions (norms), oriented by dalang artists (udanegara); basic of puppet movement refers to social class of puppet, age of puppet, class of puppet, and mood of expression of puppet; now, puppet movement becomes more and more creative and dynamic. The development of puppet movement in line with the way of thinking of society that is more improved, critical, and dynamic.
Respiration aligns perception with neural excitability
Authors: Kluger Daniel S , Balestrieri Elio , Busch Niko A , Gross Joachim
Published: December 2021

Recent studies from the field of interoception have highlighted the link between bodily and neural rhythms during action, perception, and cognition. The mechanisms underlying functional body-brain coupling, however, are poorly understood, as are the ways in which they modulate behavior. We acquired respiration and human magnetoencephalography data from a near-threshold spatial detection task to investigate the trivariate relationship between respiration, neural excitability, and performance. Respiration was found to significantly modulate perceptual sensitivity as well as posterior alpha power (8–13 Hz), a well-established proxy of cortical excitability. In turn, alpha suppression prior to detected versus undetected targets underscored the behavioral benefits of heightened excitability. Notably, respiration-locked excitability changes were maximized at a respiration phase lag of around –30° and thus temporally preceded performance changes. In line with interoceptive inference accounts, these results suggest that respiration actively aligns sampling of sensory information with transient cycles of heightened excitability to facilitate performance.
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission
Authors: Yamazaki Yasuo , Eura Yuka , Kokame Koichi
Published: December 2021

Membrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear. The hemostatic protein von Willebrand factor is produced in vascular endothelial cells and packaged into specialized secretory granules, Weibel–Palade bodies (WPBs) at the trans-Golgi network (TGN). Here, we reported that V0a1, a V-ATPase component, is required for the membrane fission of WPBs. We identified two V0a isoforms in distinct populations of WPBs in cultured endothelial cells, V0a1 and V0a2, on mature and nascent WPBs, respectively. Although WPB buds were formed, WPBs could not separate from the TGN in the absence of V0a1. Screening using dominant–negative forms of known membrane fission regulators revealed protein kinase D (PKD) as an essential factor in biogenesis of WPBs. Further, we showed that the induction of wild-type PKDs in V0a1-depleted cells does not support the segregation of WPBs from the TGN; suggesting a primary role of V0a1 in the membrane fission of WPBs. The identification of V0a1 as a new membrane fission regulator should facilitate the understanding of molecular events that enable membrane fission.
Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ
Authors: Mensa Bruk , Polizzi Nicholas F , Molnar Kathleen S , Natale Andrew M , Lemmin Thomas , DeGrado William F
Published: December 2021

Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg2+ to the sensor domain of an E. coli two component histidine kinase (HK), PhoQ, modulates its cytoplasmic kinase domain. We use cysteine-crosslinking and reporter-gene assays to simultaneously and independently probe the signaling state of PhoQ’s sensor and autokinase domains in a set of over 30 mutants. Strikingly, conservative single-site mutations distant from the sensor or catalytic site strongly influence PhoQ’s ligand-sensitivity as well as the magnitude and direction of the signal. Data from 35 mutants are explained by a semi-empirical three-domain model in which the sensor, intervening HAMP, and catalytic domains can adopt kinase-promoting or inhibiting conformations that are in allosteric communication. The catalytic and sensor domains intrinsically favor a constitutively ‘kinase-on’ conformation, while the HAMP domain favors the ‘off’ state; when coupled, they create a bistable system responsive to physiological concentrations of Mg2+. Mutations alter signaling by locally modulating domain intrinsic equilibrium constants and interdomain couplings. Our model suggests signals transmit via interdomain allostery rather than propagation of a single concerted conformational change, explaining the diversity of signaling structural transitions observed in individual HK domains.
Performance Analysis of Indie Gaming Projects on Crowdfunding Platforms: Evidence from Kickstarter.com
Authors: Stojiljković Dana R. , Mihić Marko , Bjelica Dragan
Published: December 2021

Research question: The aim of this paper is to examine the financial success of projects in game development industry in comparison with to projects in other industries hosted on crowdfunding platform Kickstarter.com. Motivation: We live in the world of technology where companies arise and disappear on daily basis. The traditional way of financing was expanded with alternative online platforms. Our goal was to conduct an empirical analysis of one crowdfunding platform (Kickstarter.com) in order to understand if technology projects are doing better than other projects. If they do, what are the key factors for their success? Idea: Our goal was to better understand how crowdfunding model supports small indie development projects and projects in other industries. Data: We used the data of 148.510 companies applied for crowdfunding financing between 2015 and 2020, published on the web crawler platform Web Robots. Tools: All statistical analyses were performed using statistical software IBM® SPSS® Statistics v.21. The data were presented using standard methods of non-parametric descriptive statistics (absolute and relative frequencies for medians and interquartile ranges for numeric outcomes). For testing of statistical significance of difference between two groups we used the Pearson´s Chi-Quadrat test and Mann-Whitney test, where appropriate. The effect size for the 2x2 analyses was estimated using Odds ratios. Findings: The paper analyses the financial success of gaming and not gaming projects and tries to identify key factors for successful funding. We found a statistically significant higher prevalence of successful financing in game development projects, with 2.3 times higher odds of successful funding compared to not-gaming industry. Our analysis of quantitative indicators such as the number of backers, goal amount, pledged amount, pledged amount per backer and pledged to goal ratio also showed that projects in game development statistically outperformed projects in other categories. Promising game projects were supported by three times more backers on average and attained almost as double funds as other projects, while still sporting more modest pledged amounts per backer. These findings support the notion of crowdfunding being a viable modality of financing independent game development in emerging economies. Contribution: This paper expands the existing research related to the crowdfunding platforms and indie development companies and formulates key factors for successful financing for technology startup firms.
Public Health Communication: Skin Cancer Prevention Implications
Authors: Krstić Jelena , Ćorić Nino
Published: December 2021

Research question: What are the characteristics of the target population which public health messages should be tailored to, in order to contribute to skin cancer prevention and early detection? Motivation: The implementation of preventive behaviour is of key importance taking into account the global increase in the incidence of skin cancer over the past decades. Communication campaigns represent an effective tool in creating awareness and education of population on harmful effects of exposure to UVR and a necessity of conducting preventive measures. The basis for creating such campaigns is to examine the knowledge, behaviour and information habits of target population. Idea: To examine the knowledge and attitudes regarding harmful effects of exposure to UVR, as well as preventive practices of adult urban population and determine the main sources of information on this topic. Data: The research took place in the period March-May 2018 in Belgrade and was based on surveing of 237 adult respondents from Belgrade. The sample was acquired by using the method of convenience sampling. Tools: The questionnaire consited of close-type questions with multiple choices of answers regarding socio-demographic characteristics, knowledge about risks of UVR exposure, preventive behaviour and preferred information sources. It was distributed in paper to patients while waiting for their appointments. Obtained data were manually coded and analysed by using SPSS. Results: A majority of both women (45.6%) and men (42.9%) report that they use sunscreens regularly, but a larger percentage of men (25% vs. 11.9%), as well as older respondents did not use sunscreens at all. Women reported to spend longer hours sunbathing (41.9% vs. 33%) and using indoor tanning than men (17.6% vs. 5.2%). Youngest respondents (age 20-30) also claim to practice excessive sunbathing (52.6%) and use indoor tanning (23.2%). Older respondents consider them being at higher risk of skin cancer (68.2% of those older than 60). There is a higher level of awareness of female in comparison with male respondents regarding the importance of skin cancer screening (62.3% vs. 44.7%), as well as of university educated respondents. Television has been noted to be the most significant source of information (57.8%), followed by internet sources (43.5%) and printed media (40.5%). Contribution: Knowledge, attitudes and behaviour, as well as preferred sources of information differ by gender, age and education of respondents so targeted public health campaigns should be tailored to specific characteristics of target groups.
The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
Authors: Zainal Baharin Nurul Hana , Khairil Mokhtar Nur Fadhilah , Mohd Desa Mohd Nasir , Gopalsamy Banulata , Mohd Zaki Nor Nadiha , Yuswan Mohd Hafis , Muthanna AbdulRahman , Dzaraly Nurul Diana , Abbasiliasi Sahar , Mohd Hashim Amalia , Abdullah Sani Muhamad Shirwan , Mustafa Shuhaimi
Published: December 2021

The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens.
Identification of quantitative trait loci underlying five major agronomic traits of soybean in three biparental populations by specific length amplified fragment sequencing (SLAF-seq)
Authors: Hu Bo , Li Yuqiu , Wu Hongyan , Zhai Hong , Xu Kun , Gao Yi , Zhu Jinlong , Li Yuzhuo , Xia Zhengjun
Published: December 2021

Flowering time, plant height, branch number, node numbers of main stem and pods per plant are important agronomic traits related to photoperiodic sensitivity, plant type and yield of soybean, which are controlled by multiple genes or quantitative trait loci (QTL). The main purpose of this study is to identify new QTL for five major agronomic traits, especially for flowering time. Three biparental populations were developed by crossing cultivars from northern and central China. Specific loci amplified fragment sequencing (SLAF-seq) was used to construct linkage map and QTL mapping was carried out. A total of 10 QTL for flowering time were identified in three populations, some of which were related to E1 and E2 genes or the other reported QTL listed in Soybase. In the Y159 population (Xudou No.9 × Kenfeng No.16), QTL for flowering time on chromosome 4, qFT4_1 and qFT4_2 were new. Compared with the QTL reported in Soybase, 1 QTL for plant height (PH), 3 QTL for branch number (BR), 5 QTL for node numbers of main stem, and 3 QTL for pods per plant were new QTL. Major E genes were frequently detected in different populations indicating that major the E loci had a great effect on flowering time and adaptation of soybean. Therefore, in order to further clone minor genes or QTL, it may be of great significance to carefully select the genotypes of known loci. These results may lay a foundation for fine mapping and clone of QTL/genes related to plant-type, provided a basis for high yield breeding of soybean.