bluuebunny/crossref_metadata_2025 huggingface dataset:
LINC01132 and LINC02542 modulate the PIK3/ACT signaling pathway in breast cancer patients through regulation of IGF2: a systems biology-based biomarker discovery
Authors: Jalalimanesh Fatemeh , Azadeh Mansoureh , Sasan Hosein Ali , Rezaei Mohammad
Published: April 2024

Background
There is ample evidence to suggest that colorectal cancer has unique originations and genetic changes and immune profiles indicating that colorectal cancer is a diverse disease.
Long non-coding RNAs (lncRNAs) perform different duties in controlling gene transcription, post-transcriptional mechanisms, translation, and epigenetic changes. dysregulated expression of lncRNAs is closely associated with a variety of medical conditions.
Method
A comprehensive bioinformatics analysis was conducted to make an informed prediction about the potential biomarkers. The selection of RNAs for this investigation was based on Microarray data analysis, enrichment analyses (pathway, GO), and direct/indirect interaction. Various statistical methods were used to assess differences in expression in the CRC samples, RNA correlations, and the potential for consideration as prognostic or diagnostic biomarkers (ROC and clinicopathological analysis).
Result
The bioinformatics analysis revealed that LINC01132 (logFC: 2.361870571, adj. P. Val < 0.05) and LINC02542 (logFC: 2.456774839, adj. P. Val < 0.05) are significantly up-regulated in CRC and have the potential to be diagnostic biomarkers for the disease, as indicated by their high area under the curve (AUC) values (LINC01132, AUC:0/9475, P. Value <0.0001 and LINC02542, AUC: 0/9075, P. Value <0.0001). Additionally, LINC02542 was found to have a positive correlation with the survival rate of CRC cases (HR: 1.8, log-rank p: 0.02). Both LINC01132 and LINC02542 were found to interact with IGF2(sum of local base-pairing energy of LINC02542: -354.52 kcal/mol, and energy of LINC01132: -69.82 kcal/mol).
Conclusion
LINC01132 and LINC02542 are novel lncRNAs in CRC, and Let-7e-5p miRNA may modulate the PI3K-AKT signaling pathway in CRC through indirect effects on IGF2.
Aerobic Bacteria Isolates and Antibiotic Susceptibility Patterns in Suspected Wound Infection Patients at Dil-Chora Referral Hospital, Dire Dawa, Eastern Ethiopia
Authors: Ibrahim Adil , Egata Gudina , Eba Wondimagegn W. , Teklemariam Zelalem , Awaju Tadesse S.
Published: April 2024

Background: Bacterial wound infections are a common and serious health problem that can disrupt wound healing, resulting in morbidity and death in patients, particularly due to drug-resistant pathogens. Limited research exists on this topic in eastern Ethiopia.
Objective: This study aims to assess aerobic bacteria isolate, their drug susceptibility patterns and associated factors among suspected patients admitted for wound infection at Dil-Chora Referral Hospital, Dire Dawa, eastern Ethiopia.
Methods: A hospital-based cross-sectional study was conducted among 188 patients with wounds from March to June 2020. Data were collected using a pretested, structured questionnaire. Wound swabs and pus discharges from 188 patients were collected using convenient sampling techniques. Gram staining, biochemical testing, and culture were used to isolate and identify etiologic agents. Antibacterial susceptibility test was performed on Muller Hinton agar using the Kirby-Bauer disc diffusion method.
Results: In this study, 89.4% of wound infections yielded bacteria, predominantly Gram-negative (54%) and Gram-positive (46%). S. aureus (32.9%) and Proteus species (28.6%) were predominant. Gender [AOR=7.5; 95% CI (5.6–13.2)], type of specimen [AOR=16.8; 95% CI (12.7–18.3)], and type of ward [AOR=12.3; 95% CI (8.3–16.5)] were significantly associated with bacterial wound infection. All isolated Gram-positive bacteria resisted Beta-lactams but responded to amikacin and vancomycin. Gram-negative bacteria showed high resistance to ampicillin, chloramphenicol, cotrimoxazole, ceftriaxone, and doxycycline, but they were susceptible to amikacin. Overall, multi-drug resistance was high at 85%.
Conclusions: Our study detected a high prevalence of bacterial wound infections with notable drug resistance. Gender (female), types of specimen (pus discharge), and types of ward (orthopedic ward) had a significant effect on the outcome variable (P< 0.05). Amikacin, gentamicin, and vancomycin emerged as preferred antibiotics at Dil-Chora hospital. Clinical diagnosis of wound infection should consider microbiological culture and susceptibility patterns for effective treatment.
Schulleitungen als Promotoren
Authors: Gerick Julia , Kieseler Janine , Herrmann Daniel , Eickelmann Birgit
Published: April 2024

Die digitalisierungsbezogene Schulentwicklung gewinnt im Zuge der zunehmenden Digitalisierung aller Lebensbereiche an Bedeutung, wobei Schulleitungen innerhalb dieser Innovationsprozesse eine besondere Rolle einnehmen. Personen, die Innovationsprozesse aktiv fördern und damit voranbringen, werden Promotoren genannt. Dieser Beitrag untersucht die (wahrgenommenen) Promotionsaktivitäten von Schulleitungen in den Bereichen Macht-, Prozess- und Fachpromotion. Mit Daten der ICILS-Studie 2018 wird untersucht, wie Schulleitungen selbst und ihre Lehrpersonen diese Schulleitungsaktivitäten wahrnehmen, inwiefern sich die beiden Akteursgruppen in ihrer Wahrnehmung unterscheiden und wie diese mit Promotionserfolg zusammenhängt. Es zeigt sich, dass Schulleitungen in unterschiedlichem Ausmass Promotionsaktivitäten zeigen, sich Schulleitungen und Lehrpersonen jedoch deutlich in ihrer Wahrnehmung voneinander unterscheiden. Lehrpersonen nehmen bei ihren Schulleitungen zu deutlich geringeren Anteilen Promotionsaktivitäten wahr als es diese selbst einschätzen. Multivariate Analysen zeigen weiterhin, dass Promotionsaktivitäten durch die Schulleitungen zwar signifikant mit den untersuchten Indikatoren des Promotionserfolgs zusammenhängen, der Grad dieser Zusammenhänge jedoch eher gering ist. Nichtsdestotrotz nehmen Schulleitungen als Promotoren eine bedeutende Rolle in digitalisierungsbezogenen Schulentwicklungsprozessen ein und sollten folglich hinsichtlich ihrer Gestaltungsmöglichkeiten im Sinne der Promotion und ebenso hinsichtlich der Bedeutung der Wahrnehmung ihres Führungshandelns sensibilisiert werden, um digitalisierungsbezogene Schulentwicklungsprozesse zu unterstützen.
Soll das bloße Anlegen von Feindeslisten strafbar sein? : § 126a StGB auf dem Prüfstand
Authors: Grosser Marcel
Published: April 2024

Mit dem am 22. September 2021 neu in Kraft getretenen § 126a StGB, der nun explizit das Anlegen von Feindeslisten unter Strafe stellt, sollen Menschen (noch) besser gegen Hass und Hetze im Internet geschützt werden. So legitim diese Intention auch ist, drängt sich gleichsam die Frage auf, ob diesem Phänomen wirkungsvoll mit dem Strafrecht entgegnet werden kann und aus rechtsstaatlicher Perspektive überhaupt werden darf. Unter dieser Prämisse wird kritisch eruiert, ob und inwiefern sich § 126a StGB in das dogmatische Gerüst des Strafrechts einordnen lässt. Dabei ist § 126a StGB dem modernen Präventionsstrafrecht zuzuordnen. Dieses verfolgt den Ansatz, durch eine Vorverlagerung der Strafbarkeit das Strafrecht als funktionales Mittel zur Erhöhung des Sicherheitsgefühls zu instrumentalisieren. Nach der Bewertung der tatsächlichen Bedrohungslage wird der Handlungsunwert der Verbreitung von Feindeslisten analysiert. Daneben werden weitere Grenzen der strafrechtlichen Vorverlagerung beleuchtet, namentlich die fundamentalen Prinzipien des Tatstrafrechts, des Bestimmtheitsgebots und des Ultima-Ratio-Grundsatzes, an denen sich § 126a StGB messen lassen muss.
Moulting Performances Evaluation of Female Orange Mud Crab, Scylla olivacea (Herbst, 1796) In-Captivity: Effects of Water Salinity and Limb Autotomy
Authors: Adnan Amin-Safwan  , Lawrencia Casey Gamburud  , Mohd Affendi Izzah-Syafiah  , Mohd Pauzi Mardhiyyah  , Hairul Hafiz Mahsol  , Muhammad Taufik  , Hidayah Manan  , Muhammad Naimullah  , Che Ismail Che-Zulkifli  , Harman Muhd-Farouk  , Muhammad Nur Syafaat  , Nadirah Musa  , Hongyu Ma  , Mhd Ikhwanuddin
Published: April 2024

Female Scylla olivacea has become more popular in Malaysia as emerging species mainly for soft-shell crabs and crab fattening (to increase weight, size and ovary maturation so that they can be sold at a higher price). To harvest crabs in soft-shell conditions and fattening, both conditions depend mostly on moulting events. To accelerate the moulting process, the manipulation of water parameter (salinity) and autotomy of the limb is commonly used. In this study, the evaluation of the moulting performances of full limb autotomy (the removal of all the appendages except for the swimming legs) and non-ablated (control) using immature S. olivacea cultured in three different salinity treatments (10 ppt, 20 ppt and 30 ppt) were performed. Results indicate there were significant differences between mud crab’s culture duration, BW increments, growth performances and feeding efficiency with salinity. However, CW increments and survival indicate no significant effect with salinity. Meanwhile, limb autotomy proved to affect the culture duration, BW increments, survival and feeding efficiency of S. olivacea. The study concludes that both salinity and limb autotomy play significant roles in moulting performances of S. olivacea, with 20 ppt being the best salinity to stimulate S. olivacea moulting and development compared with the other two treatments (10 ppt and 30 ppt). Limb autotomy also indicates promising results as this technique proved to accelerate the moulting duration of S. olivacea with a 100% moulting percentage within 30 days. Therefore, the outcome would certainly benefit in the aquaculture production of this species of commercial importance mainly on soft-shell crabs production and also emerge as crabs fattening technique.
Species Identification of Rehabilitated Critically Endangered Orangutans Through DNA Forensic: Implication for Conservation
Authors: Christy Lavenia  , Dwi Sendi Priyono  , Donan Satria Yudha  , Tuty Arisuryanti
Published: April 2024

Rehabilitating and releasing orangutans back into the wild is one of the conservation strategies being pursued to conserve orangutans. However, the species determination between Sumatran, Tapanuli, and Bornean orangutans is essential for reintroduction to avoid outbreeding depression, which could lead to DNA hybridisation and increase the probability of recessive characters. Here, we reported on an investigation of three orangutans in which DNA forensic techniques were used to identify the species before release and reintroduction to their habitat. By applying DNA forensic, the orangutan was successfully confirmed with high probabilities (100%) by identifying two orangutan species, Pongo abelii and Pongo pygmaeus wurmbii. Based on ambiguous morphology, we found the possibility of orangutan species being misidentified in rehabilitation. This case report demonstrates the importance of molecular diagnostics to identify the orangutan species. We also provide workflow recommendations from genetic aspect for rehabilitated orangutans. These recommendations will enable decision-makers to consider genetics when assessing future management decisions, which will help ensure that the orangutan species is effectively conserved.
Måleegenskaper ved den norske versjonen av Youth Level of Service/CaseManagement Inventory (YLS/CMI)
Authors: Jakobsen Reidar , Kornør Hege
Published: April 2024

Beskrivelse: Youth Level of Service/Case Management Inventory (YLS/CMI) er utviklet i Canada av Andrews og Hoge på 1990-tallet, til hjelp i utvikling og oppfølging av tiltaksplaner for unge lovbrytere (12-17 år). YLS/CMI kartlegger ungdommens styrker og behov, utfordringer og motivasjonsfaktorer, herunder ungdommens motivasjon og tilgjengelighet for ulike tiltak. I Norge er YLS/CMI implementert som en del av Bufetats monitorering av ungdom som plasseres i institusjon pga. rus- eller atferdsvansker.. YLS/CMI består av 42 ledd som grupperes i åtte subskalaer og en total risiko- og behovsskåre. Instrumentet forutsetter at den som er ansvarlig for administreringen og tolkningen har høyere utdanning når det gjelder psykologiske tester eller tilsvarende. YLS/CMI gjennomføres som et semistrukturert intervju (30-40 minutter). Rettighetene til testen holdes av Multi Health Systems Inc, North Tonawanda, NY, US.
Litteratursøk: Vårt systematiske litteratursøk etter dokumentasjon for måleegenskapene ved de skandinaviske versjonene av YLS/CMI identifiserte ingen relevante publikasjoner. Vi fant og inkluderte én norsk studie som rapporterte gjennomsnittsskårer i tre barnevernsutvalg.
Konklusjon: Det foreligger ingen dokumentasjon for måleegenskapene ved den norske versjonen av YLS/CMI. Det er derfor nødvendig med studier som undersøker måleegenskaper.
Måleegenskaper ved den norske versjonen av Kartlegging av traumeerfaringer og symptomer (KATES Barn)
Authors: Borren Ingrid , Kaiser Sabine
Published: April 2024

Beskrivelse: Kartlegging av traumeerfaringer og symptomer (KATES Barn) er et screeninginstrument for barn i alderen 7–17 år som gir foreløpig informasjon om mulig posttraumatisk stress. KATES Barn kommer i to deler; del 1 fanger opp traumatiske hendelser, og del 2 måler symptomer på posttraumatisk stress. Del 2 er delt opp i fire symptomkategorier tilpasset de diagnostiske endringene av traumediagnosen i DSM-5. KATES Barn er utviklet og validert av Sachser et al. (2017). Nasjonalt Kunnskapssenter om Vold og Traumatisk Stress var involvert i utviklingen av skalaen og ansvarlig for den norske oversettelsen.
Litteratursøk: Litteratursøket resulterte i en norsk artikkel og en svensk hovedoppgave som inneholdt relevant psykometrisk informasjon og ga grunnlag for vurderingen.
Psykometri: Resultatene tyder på tilstrekkelig/god indre konsistens for de fire skalaene. I det svenske utvalget fant man også tilstrekkelig test-retest-reliabilitet for totalskåren. Konfirmerende faktoranalyse på et blandet utvalg med barn fra Norge, USA og Tyskland viste at faktorstrukturen var i henhold til DSM-5s firefaktorteori for posttraumatisk stresslidelse (PTSD). Det ble også funnet støtte for konvergent validitet, og for konstruktvaliditet. De svenske normene gir begrenset informasjon om alder og geografi, og norske normer for testen mangler.
Konklusjon: Dokumentasjonsgrunnlaget er ikke tilstrekkelig til å konkludere sikkert om de psykometriske egenskapene til KATES Barn. Det trengs flere studier på skandinaviske utvalg, ikke minst normdata. Testen må derfor brukes med forsiktighet i Norge.
Måleegenskaper ved den norske versjonen av Social Communication Questionnaire (SCQ)
Authors: Kaasbøll Jannike , Jozefiak Thomas , Aanondsen Chris Margaret
Published: April 2024

Beskrivelse. Social Communication Questionnaire (SCQ) er et kartleggingsinstrument for bedømming av kommunikasjonsmåter og sosial funksjon hos barn ved mistanke om autismespekterforstyrrelse. Den norske oversettelsen av Synnøve Schjølberg og Kristian Tambs er basert på den britiske originalen av SCQ som ble utviklet av Rutter, Bailey, og Lord i 2003. Spørreskjemaet består av 40 testledd for både en nåtids- og livsløpsvurdering med en to-delt- skala (ja eller nei). Skjemaet kan fylles ut av både foreldre og nære omsorgspersoner. Spørreskjemaet tar ti minutter å fylle ut. Brukergrupper er psykolog, lege, sosionom, sykepleier, logoped, arbeidsterapeut, fysioterapeut, eller spesialpedagog. Den norske utgaven av SCQ er tilgjengelig fra Hogrefe Psykologiförlaget AB.
Litteratursøk: Vårt systematiske litteratursøk resulterte i 301 treff, hvorav 13 publikasjoner fra skandinaviske land ble inkludert. Fire av disse 13 artiklene omhandlet til dels små utvalg med spesifikke syndromer.
Psykometri: Gjennomsnittsverdier og standardavvik ble oppgitt i de fleste inkluderte artiklene. Ingen norske eller skandinaviske normer, analyser av faktorstruktur eller kriterievaliditet ble rapportert. Kun en av studiene rapporterte intern konsistens.
Konklusjon: Samlet sett vurderes dokumentasjonsgrunnlaget for de psykometriske egenskapene ved den norske utgaven av SCQ som noe begrenset.
Måleegenskaper ved den norske versjonen av Marschak Interaction Method (MIM)
Authors: Rye Marte , Drozd Filip
Published: April 2024

Beskrivelse: Marschak Interaction Method (MIM) er en observasjonsmetode utviklet for å undersøke og vurdere samspillet mellom barn og omsorgsgiver. MIM ble utviklet av Marianne Marschak (1960) og senere tilpasset til bruk sammen med intervensjonen Theraplay. Rettighetshaver for MIM er the Theraplay Institute. MIM består av ulike oppgaver som omsorgsgiver og barnet utfører sammen. Oppgavene er utformet for å gi informasjon om de fire Theraplay-dimensjonene Struktur (Structure), Engasjement (Engagement), Omsorg (Nurture) og Utfordring (Challenge). Det er utviklet ulike systemer for å skåre MIM, for eksempel the Marschak Interaction Method Rating System (MIMRS), Dyadic Emotional Interaction Style (D-EIS) og MIM-Psychometrics (MIM-P).
Litteratursøk: Litteratursøket resulterte i to inkluderte studier som benyttet to ulike skåringssystemer for MIM. Begge studiene er tverrsnittsundersøkelser gjennomført i Danmark med et beskjedent antall deltakere. Den ene artikkelen involverer flyktningfamilier med barn under 18 år (n = 21) henvist for behandling som følge av familievold, mens den andre involverer foreldre med barn i alderen 4 – 12 år (n = 36) henvist som følge av familierelaterte vansker.
Psykometri: Begge artikler rapporterer interraterreliabilitet og det er gjort undersøkelser vedrørende konstruktvaliditet. Ingen av artiklene rapporterer indre konsistens og det foreligger heller ikke undersøkelser av andre former for validitet.
Konklusjon: Det foreligger ingen kartlegging av observasjonsmetoden MIMs psykometriske egenskaper i Skandinavia. Tilstedeværelsen av ulike skåringssystem kompliserer en helhetlig vurdering av reliabilitet og validitet av MIM. For alle skåringssystem fremkommer det behov for ytterligere utforsking av deres psykometriske egenskaper i utvalg med tilstrekkelig antall deltagere.
Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier
in Cancer Therapy
Authors: Singh Dilpreet , Muhammad Irham Lalu , Singh Amrinder , Kurmi Balak Das
Published: April 2024

The landscape of cancer therapy has witnessed a paradigm shift with the emergence of
innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard
in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility,
these dendrimers offer a promising avenue for the targeted delivery of therapeutic
cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium-
based Peptide Dendrimers, unraveling their structural intricacies, mechanisms of action, and
advancements that have propelled them from laboratory curiosities to potential clinical champions.
Exploiting the potent properties of guanidinium, these dendrimers exhibit unparalleled precision
in encapsulating and transporting diverse cargo molecules, ranging from conventional chemotherapeutics
to cutting-edge nucleic acids. The review navigates the depths of their design principles,
investigating their prowess in traversing the complex terrain of cellular barriers for optimal
cargo delivery. Moreover, it delves into emerging trends, such as personalized therapeutic approaches,
multimodal imaging, and bioinformatics-driven design, highlighting their potential to redefine
the future of cancer therapy. Crucially, the review addresses the pivotal concerns of biocompatibility
and safety, examining cytotoxicity profiles, immune responses, and in vivo studies. It underscores
the importance of aligning scientific marvels with the stringent demands of clinical applications.
Through each section, the narrative underscores the promises and possibilities that
Guanidinium-based Peptide Dendrimers hold and how they can potentially reshape the landscape
of precision cancer therapy.
Recent Progress in the Synthesis and Biological Assessment of Benzimidazole-1,2,3-
Triazole Hybrids
Authors: Singh Dileep Kumar , Iqbal Haider , Ansari Mohd. Ayub
Published: April 2024

In recent times, many research groups have focused their attention on nitrogencontaining
heterocyclic compounds with the aim of gaining a deeper understanding of their
biological characteristics. Among them, molecules based on 1,2,3-triazole and benzimidazole
have exhibited diverse biological applications and are present in many drug molecules.
The purpose of this review is to describe various benzimidazole-1,2,3-triazole hybrids and
to provide a comprehensive evaluation of their biological properties. The compounds discussed
in this study have been synthesized through a Cu(I)-catalyzed 1,3-dipolar cycloaddition
reaction between diverse azides and alkynes, utilizing a 1,2,3-triazole scaffold as a
linkage between two connecting groups. The synthesis of several benzimidazole-1,2,3-
triazole hybrids is covered in this review, along with a biological assessment of their anticancer, antiproliferative,
antitubercular, antibacterial, antidepressant, and other activities. Moreover, in our opinion, this review may
be useful for the development of various medicinally significant molecules.
Detection and Quantification of 5moU RNA Modification from Direct
RNA Sequencing Data
Authors: Li Jiayi , Sun Feiyang , He Kunyang , Zhang Lin , Meng Jia , Huang Daiyun , Zhang Yuxin
Published: April 2024

Background:

Chemically modified therapeutic mRNAs have gained momentum recently.
In addition to commonly used modifications (e.g., pseudouridine), 5moU is considered a promising
substitution for uridine in therapeutic mRNAs. Accurate identification of 5-methoxyuridine
(5moU) would be crucial for the study and quality control of relevant in vitro-transcribed (IVT)
mRNAs. However, current methods exhibit deficiencies in providing quantitative methodologies
for detecting such modification. Utilizing the capabilities of Oxford nanopore direct RNA sequencing,
in this study, we present NanoML-5moU, a machine-learning framework designed specifically
for the read-level detection and quantification of 5moU modification for IVT data.

Materials and Methods:

Nanopore direct RNA sequencing data from both 5moU-modified and
unmodified control samples were collected. Subsequently, a comprehensive analysis and modeling
of signal event characteristics (mean, median current intensities, standard deviations, and dwell
times) were performed. Furthermore, classical machine learning algorithms, notably the Support
Vector Machine (SVM), Random Forest (RF), and XGBoost were employed to discern 5moU modifications
within NNUNN (where N represents A, C, U, or G) 5-mers.

Result:

Notably, the signal event attributes pertaining to each constituent base of the NNUNN 5-
mers, in conjunction with the utilization of the XGBoost algorithm, exhibited remarkable performance
levels (with a maximum AUROC of 0.9567 in the "AGTTC" reference 5-mer dataset and a minimum
AUROC of 0.8113 in the "TGTGC" reference 5-mer dataset). This accomplishment markedly exceeded
the efficacy of the prevailing background error comparison model (ELIGOs AUC 0.751 for sitelevel
prediction). The model's performance was further validated through a series of curated datasets,
which featured customized modification ratios designed to emulate broader data patterns, demonstrating
its general applicability in quality control of IVT mRNA vaccines. The NanoML-5moU framework
is publicly available on GitHub (https://github.com/JiayiLi21/NanoML-5moU).

Conclusion:

NanoML-5moU enables accurate read-level profiling of 5moU modification with nanopore
direct RNA-sequencing, which is a powerful tool specialized in unveiling signal patterns in
in vitro-transcribed (IVT) mRNAs.
Electroacupuncture Inhibits Neural Ferroptosis in Rat Model of Traumatic
Brain Injury via Activating System Xc−/GSH/GPX4 Axis
Authors: Li Na , Wang Ruihui , Ai Xia , Guo Jie , Bai Yuwang , Guo Xinrong , Zhang Rongchao , Du Xu , Chen Jingxuan , Li Hua
Published: April 2024

Background:

Ferroptosis is an iron-dependent regulating programmed cell death discovered
recently that has been receiving much attention in traumatic brain injury (TBI). xCT, a
major functional subunit of Cystine/glutamic acid reverse transporter (System Xc-), promotes
cystine intake and glutathione biosynthesis, thereby protecting against oxidative stress and ferroptosis.

Objective:

The intention of this research was to verify the hypothesis that electroacupuncture
(EA) exerted an anti-ferroptosis effect via an increase in the expression of xCT and activation of
the System Xc−/GSH/GPX4 axis in cortical neurons of TBI rats.

Methods:

After the TBI rat model was prepared, animals received EA treatment at GV20,
GV26, ST36 and PC6, for 15 min. The xCT inhibitor Sulfasalazine (SSZ) was administered 2h
prior to model being prepared. The degree of neurological impairment was evaluated by means
of TUNEL staining and the modified neurological severity score (mNSS). Specific indicators of
ferroptosis (Ultrastructure of mitochondria, Iron and ROS) were detected by transmission electron
microscopy (TEM), Prussian blue staining (Perls stain) and flow cytometry (FCM), respectively.
GSH synthesis and metabolism-related factors in the content of the cerebral cortex were
detected by an assay kit. Real-time quantitative PCR (RT-QPCR), Western blot (WB), and immunofluorescence
(IF) were used for detecting the expression of System Xc−/GSH/GPX4 axisrelated
proteins in injured cerebral cortex tissues.

Results:

EA successfully relieved nerve damage within 7 days after TBI, significantly inhibited
neuronal ferroptosis, upregulated the expression of xCT and System Xc-/GSH/GPX4 axis forward
protein and promoted glutathione (GSH) synthesis and metabolism in the injured area of
the cerebral cortex. However, aggravation of nerve damage and increased ferroptosis effect were
found in TBI rats injected with xCT inhibitors.

Conclusions:

EA inhibits neuronal ferroptosis by up-regulated xCT expression and by activating
System Xc−/GSH/GPX4 axis after TBI, confirming the relevant theories regarding the EA effect
in treating TBI and providing theoretical support for clinical practice.
Iodine-Mediated Aromatization of Himachalenes: Synthesis of Dehydro-7,8-arylhimachalene
Authors: Louchachha Isam , Edder Youssef , Faris Abdelmajid , Boualy Brahim , Ali Mustapha Ait , Karim Abdallah
Published: April 2024

:

Dehydro-7,8-aryl-himachalene is a desired natural benzocycloheptene sesquiterpene
found in the essential oil of Atlas cedar (Cedrus atlantica) in minor quantities. Herein, we report a
simple and environmentally benign synthesis of this molecule via the aromatization of himachalene
mixture (the major constituent of the same oil).

:

The synthesis of the desired compound has been achieved by iodine/DMSO-mediated aromatization.
The synthesized product has been characterized using MS spectrometry and NMR spectroscopy data.

:

The treatment of the himachalene mixture with iodine led to the formation of dehydro-7,8-arylhimachalene,
along with other rearrangement products catalyzed by the hydroiodic acid formed in
situ. The use of DMSO as a co-solvent enabled the elimination of the acid formed and the regeneration
of iodine. The optimization of the reaction conditions led to the formation of the desired product
with a good yield.

:

The present study highlights the development of a simple and environmentally benign method for the
synthesis of a natural benzocycloheptene-based sesquiterpenoid in large quantities in order to explore
its biological and chemical properties.
Synthesis, Characterization, Docking Studies, and In-vitro Cytotoxic Activity of Some Novel 2, 3 Disubstituted Naphthalene 1,4 Dione Derivatives
Authors: Selavaraj Dilipkumar , Vishwanathan Karthik , Byran Gowramma , Mohan Magesh , Lakshmanan Kaviarasan
Published: April 2024

Introduction:

Many quinone derivatives as of now utilized for anticancer medications.
Especially, 1,4-naphthoquinones are dynamic derivatives, and it was broadly utilized in unrefined
substances in the drugs and agrochemicals industry.

Materials and Methods:

In this work, we planned and combined five different moieties into 2, 3
disubstituted naphthalene-1,4-dione molecules. Various spectral studies distinguished the synthetic
designs of the produced compounds. The naphthoquinone derivatives were exposed to the primary
molecular descriptor by Molinspiration programming, and all the descriptor values are within
the specified value.

Results and Discussion:

Each of the five naphthoquinone derivatives was docked against the
Topoisomerase II utilizing Auto Dock program 4.2.5. (PDB: 3L4K). The docking tells us that the
studied compounds possess significant to moderate inhibition toward the targeted enzymes.
Among the studied compounds, compound L3 showed the most elevated binding score (-10.66
kcal/mol with one H-bond) than the adriamycin (-9.58 kcal/mol with two H-bonds) and compound
L2 (- 9.86 kcal/mol with two H-bonds). The derivatives were tried for in-vitro cytotoxicity
studies against MCF - 7 by the SRB method. Among them, compounds L2 (28.42±3.1 μg/mL)
and L3 (29.38±3.2 μg/mL) were the most significant ones when contrasted with the control Adriamycin
(15.28±3.4 μg/mL).

Conclusion:

The current research indicates that the tested compounds show anticancer action
against the MCF-7 breast cancer cell line. Thus, the study is an attempt to advance toward the
identification of innovative anticancer drugs.
Revealing the Potential of Mucoadhesive Ocular Nanoparticles for Enhanced Drug Delivery
Authors: Maheshwari Shubhrat , Singh Aditya , Wasim Rufaida , Prajapati Bhupendra G. , Malviya Rishabha , Shazly Gamal A.
Published: April 2024

An ocular drug delivery system, or ODDS, is the method for executing a prescription to
the peeper in order to treat or manage conditions related to the eyes. The range of ODDS modalities
is broad and includes simple aseptic eye drops for the optic surface as well as complex implants
for intraocular tissue. The use of ODDS is often necessary for states such as cataracts, progressive
retinal illness, inflammation, dry eye syndrome, diabetic retinopathy (DR), and other related
diseases or disorders. To sustain the intended drug concentrations at the prescribed place,
new drug delivery technologies have been developed, incorporating fibrin-sealing materials and
sticky gels. The advancement of long-lasting drug delivery systems that are non-invasive and applied
externally to the back portion of the eye possesses the potential to improve drug administration
significantly. The progress made in the field of ophthalmic drug delivery has resulted in
promising advancements in the treatment of diseases affecting both the front and back portions of
the eye. These groundbreaking strategies for administering medication hold immense potential for
enhancing drug delivery in the future. Furthermore, these inventive devices and/or formulations
are easy to develop, causing minimal or negligible irritation, boasting a prolonged period residing
in front of the cornea, sustaining the release of drugs, and increasing the therapeutic availability of
medications within the eye. To remain up to date with the current advancements in the field of ocular
drug delivery, it is essential to acquire the latest information. This helps drug delivery scientists
improve their thought processes and also makes it possible to create fresh, trustworthy drug
delivery methods. The objective of this investigation is to provide a thorough investigation while
also tracking their advancement. Next, we shall examine the latest breakthroughs in formulation innovations
based on nanotechnology. We will also discuss the most recent developments in additional
ocular medication administration methods, including in-situ gels, implants, contact lenses, and
microneedles.
A Cost-Minimized Task Migration Assignment Mechanism in Blockchain Based Edge Computing System
Authors: Xu Binghua , Jin Yan , Yu Lei
Published: April 2024

Background:

Cloud computing is usually introduced to execute computing intensive
tasks for data processing and data mining. As a supplement to cloud computing, edge
computing is provided as a new paradigm to effectively reduce processing latency, energy consumption
cost and bandwidth consumption for time-sensitive tasks or resource-sensitive tasks.
To better meet such requirements during task assignment in edge computing systems, an intelligent
task migration assignment mechanism based on blockchain is proposed, which jointly
considers the factors of resource allocation, resource control and credit degree.

Methods:

In this paper, an optimization problem is firstly constructed to minimize the total
cost of completing all tasks under constraints of delay, energy consumption, communication,
and credit degree. Here, the terminal node mines computing resources from edge nodes to
complete task migration. An incentive method based on blockchain is provided to mobilize the
activity of terminal nodes and edge nodes, and to ensure the security of the transaction during
migration. The designed allocation rules ensure the fairness of rewards for successfully mining
resource. To solve the optimization problem, an intelligent migration algorithm that utilizes a
dual “actor-reviewer” neural network on inverse gradient update is proposed which makes the
training process more stable and easier to converge.

Results:

Compared to the existing two benchmark mechanisms, the extensive simulation results
indicate that the proposed mechanism based on neural network can converge at a faster
speed and achieve the minimal total cost.

Conclusion:

To satisfy the requirements of delay and energy consumption for computing intensive
tasks in edge computing scenarios, an intelligent, blockchain based task migration assignment
mechanism with joint resource allocation and control is proposed. To realize this
mechanism effectively, a dual “actor-reviewer” neural network algorithm is designed and executed.
Establishment and Poetic imagery of Yukyuk-dong, a scenic spot in Pyeongan-do in the Late Joseon Dynasty
Authors:   The Association of DaeDong-Hanmun, Yim Young-gil
Published: April 2024

This article introduces Yukyuk-dong (or thirty six Dongcheon) in Samdeung-hyeon, which was highlighted in the 19th century as one of the famous scenic spots in Pyeongan-do, and explains the origins of the names of the 36 Dongcheon and the characteristics of the Chinese poem ‘Yukyuk- dong’ created based on each Dongcheon. The extant Chinese poems based on Yukyuk-dong were mostly written in the 19th century, and the tendency of some writers to form a series of 36 poems is captured. Eom Gi (1760~1820), who first gave names to the 36 Dongcheon in Yukyuk-dong at the end of the 18th century, revealed the origins of each Dongcheon and reproduced the actual scenery into 36 poems composed in seven-word verse. While projecting legends related to immortals, he paid attention to topographical characteristics such as strangely shaped rocks, cliffs, waterfalls, and the unique flow of rivers, and expressed each Dongcheon by reflecting the natural phenomena or human activities he captured. Eom Gi's poem had a profound influence on the creation of a series of poems by the group of Shin Heon, Jo Yeon-myeong, Kim Hyeon-eung, and Lee Heon-myeong while touring Yukyuk-dong in 1837. Each of these four people's exchanging poems is compiled together with Eom Gi's poem under the title Yukyuk Yeonhwa, and generally uses materials similar to Eom Gi's to establish the image of Yukyuk-dong. Meanwhile, in the early 19th century, Shin Wi (1769~1845), Jo Deuk- young (1762~1824), and Jeong Won-yong (1783~1873), each wrote 36 poems composed in five-word verse to describe Yukyuk-dong. They connected the history of immortals and Buddhist legends, Chinese writers, and place names etc with the poems but embodied in different content from Eom Gi's poem. The series of ‘Yukyuk-dong’ poems created by 19th century writers not only contributed to securing the status of Yukyuk-dong as a scenic spot, but are also significant in that they show an aspect of the cultural phenomenon of discovery and enjoyment of scenic spots.
Translation and Annotation of Chunhyangjeon writtenby Yeo Gyu-hyeong
Authors:   The Association of DaeDong-Hanmun, Kim Soo-young , Song Jeongwoo , Ham Juhee , Qui Ruiqing
Published: April 2024

In the early 20th century, Yeo Gyu-hyeong was commissioned by the Wongaksa(圓覺社) to create the drama Chunhyangjeon written in Classical Chinese. Yeo Gyu-hyeong's Chunhyangjeon is a unique text that shows the contemporary changes in pansori literature and has points worthy of further discussion in several adjacent academic fields. Nonetheless, a complete translation of this work has not yet been done. Therefore this paper preliminarily examined the bibliographic characteristics and genre of Yeo Gyu-hyeong's Chunhyangjeon and performed punctuation, translation, and commentary on the entire text.
Nurturing Creativity and Talent in After-School Musical Societies under the 'Double Reduction' Policy in China
Authors: Zhu Yanting , Jamaludin Juriani
Published: April 2024

In 2021, China issued the "Opinions on Further Reducing the Homework and Off Campus Training Burden of Students in Compulsory Education". This title highlights the element of innovation within after-school musical societies in Nanjing's primary schools, showcasing their ability to adapt and find creative solutions within the constraints of the 'Double Reduction' policy. This paper examines the after-school musical societies in three primary schools in Nanjing within the context of the 'double reduction' policy. Through questionnaire survey and interviews, it aims to explore the current state of these societies and identify the challenges they face in their establishment.
Learning Writing Online and Online Collaborative Writing
Authors: Noorezam Maisarah , Sa’adan Nadzrah , Ibrahim Nursuhaila , Zakaria Nursyuhada , Rahmat Noor Hanim
Published: April 2024

Online collaborative writing views and factors have yet to be discussed despite its ease and popularity in this era. This study examines online collaborative writing and its motivation and demotivation aspects. It also looks into the relationship between learning writing online and online collaborative writing. This quantitative study obtained responses from 123 language learners. The questionnaire consists of 6 sections with 63 items in total. Findings show positive perception and relation towards learning writing online and online collaborative writing. This study shed light on the benefits and limitations of online writing, especially on the teaching and learning aspects.
Assessing Malaysian Health Care Reform
Authors: Che Soh Mazlan , A. Samad Suhaimi , Yusof Radduan , Kamarunzaman Nur Zafifa
Published: April 2024

This study assesses the healthcare reform in Malaysia since its independence. Previous studies and official reports on healthcare reform were analyzed through content analysis. The discussion starts with geographical and socioeconomic factors, then moves to the inception of the Malaysian Health Care System, focusing on the development of primary health system reform initiatives in the country. This paper illustrates the rigorous journey of system reform, emphasizing that political commitment and backing from stakeholders and citizens are vital for its success
Two Side of the Same Coin: Accessibility and affordability for healthcare in Sabah
Authors: Abd Samad Suhaimi , Ahmad Jasmine , Mohd Tahir Nor Suziwana , Abdullah Nuraisyah Chua
Published: April 2024

This article is to identify the level of accessibility and affordability of people in Sabah for quality healthcare. In-depth interviews were conducted with eight informants through qualitative research, and it is found that accessibility issue is very crucial which is due to more cost for travelling and ultimately related to affordability. Various initiatives require commitment from the government and community yet to be effective due to budget constraint, lack of awareness and community ability. All parties concern in healthcare needs to work as a team in ensuring that no one is left out from quality healthcare to achieve sustainable development goal of 2030.
An Uphill Battle: A systematic literature review on the challenges of addressing Child Sexual Abuse (CSA) in the developing countries
Authors: Adam Ameena , Ahmad Yarina , Kassim Asiyah
Published: April 2024

Despite worldwide concern over child sexual abuse (CSA), studies on barriers of combating it are still limited. Most studies focusing on the contributing factors particularly from the societal perspectives. Hence this article presents a systematic literature review on challenges in addressing CSA in the context of developing countries in Asia. Using PRISMA protocol, 17 articles from 2017 till present were selected. Several themes emerged leading to the conceptualization of the challenges in dealing with CSA which include taboo and social stigma, poverty and economic vulnerability, witnesses of the legal system, lack of knowledge and institutional and structural challenges.
Developing Enterprise Risk Management Disclosure Index using Factor Analysis
Authors: Syed Mohd Fuzi Sharifah Faatihah , Hassan Mohamat Sabri , Othman Sarina , Moulton Noorie Haryaniee
Published: April 2024

This study aims to explore the Enterprise Risk Management (ERM) disclosure by publicly listed firms in Malaysia. This study analyses a sample of 832 non-financial publicly listed firms in Malaysia between 2016-2019. This study used a more comprehensive index by embedding COSO-integrated ERM framework 2017 and ISO 31000. The data is analyzed using factor analysis to develop the ERM disclosure index. The results show that ERM disclosure consists of 4 main components: governance and culture, performance, objective setting, and reporting approach. Meanwhile, the level of ERM disclosure is still at a moderate level.
Malaysia Madani Policy Concept in Kelantan State
Authors: Wan Sulaiman Wan Salwana , Tan Abdullah Iskandar Hasan , Wan Mohamad Wan Mohd Firdaus , Ahmad Mohd Miqdad Aswad , Raja Karim Raja Symsul Haq , Iskandah Mohd Faiz , Hussin Siti Nor Adawiah , Ahmad Afip Nadhira
Published: April 2024

PAS’s ruling from 1990 until now has caused the existence of two different Islamic government systems with the Federal Government in this country's democratic system. Objectively is to look at the fate of indigenous people in Malaysia Madani in terms of poverty, cost of living, affordable housing, soft prosperity, and the future of the young generation in Kelantan. The methodology of this study is to evaluate, observe and analyze every situation through qualitative approach. The result will impact on understanding and reform that needs to be done in improving the socio-life of the people of Kelantan in today's Malaysia Madani.
Role of Social Demography Factors in Economic Growth and Sustainability Models: Evidence from selected emerging economies
Authors: Pardi Faridah , Yasin Mohammad Yuzaimi , Zainal Abedin Nur Fadhlina , Junos Sutina
Published: April 2024

A country’s social demography characteristics are described by population dynamics and technology-based lifestyle changes. Such unique elements may correlate with economic growth and sustainability. In this study, a static panel data model analysis for economic growth and sustainable development of ten emerging economies was presented. Estimation results revealed that social demography factors exhibited a negative significant impact in both economic models, relative to the technological influence. Therefore, effective macroeconomic policies should be meticulously designed against changing demographic trends. Conclusively, by delivering focused public services to the urban area, more liveable cities will emerge to empower human capital development.
Exploring the Business Survival and Resilient Strategies for Hotel Owners during Covid-19 Pandemic: A systematic and critical review
Authors: Abdul Rahim Memiyanty , Mahamad Aziz Farhatul Mustamirrah , Razali Hazariah Yais , Hardinigsih Sri
Published: April 2024

The Covid-19 pandemic has had critical impacts on the hotel and tourism industry. There are unclear insights on the business survival strategies in the hotel industry during the crisis. This paper aims to scrutinize the implications of the Covid-19 Movement Control Order (MCO) on the hotel industry and identify survival strategies based on reviewing several publications from 2019 till now. This study could assist the regulators in governing the policy for business owners to face any crises in the future with the right strategies.
Evaluating the Prevalence of Burnout Among Health Care Professionals Related to Electronic Health Record Use: Systematic Review and Meta-Analysis
Authors: Wu Yuxuan , Wu Mingyue , Wang Changyu , Lin Jie , Liu Jialin , Liu Siru
Published: April 2024

Background

Burnout among health care professionals is a significant concern, with detrimental effects on health care service quality and patient outcomes. The use of the electronic health record (EHR) system has been identified as a significant contributor to burnout among health care professionals.

Objective

This systematic review and meta-analysis aims to assess the prevalence of burnout among health care professionals associated with the use of the EHR system, thereby providing evidence to improve health information systems and develop strategies to measure and mitigate burnout.

Methods

We conducted a comprehensive search of the PubMed, Embase, and Web of Science databases for English-language peer-reviewed articles published between January 1, 2009, and December 31, 2022. Two independent reviewers applied inclusion and exclusion criteria, and study quality was assessed using the Joanna Briggs Institute checklist and the Newcastle-Ottawa Scale. Meta-analyses were performed using R (version 4.1.3; R Foundation for Statistical Computing), with EndNote X7 (Clarivate) for reference management.

Results

The review included 32 cross-sectional studies and 5 case-control studies with a total of 66,556 participants, mainly physicians and registered nurses. The pooled prevalence of burnout among health care professionals in cross-sectional studies was 40.4% (95% CI 37.5%-43.2%). Case-control studies indicated a higher likelihood of burnout among health care professionals who spent more time on EHR-related tasks outside work (odds ratio 2.43, 95% CI 2.31-2.57).

Conclusions

The findings highlight the association between the increased use of the EHR system and burnout among health care professionals. Potential solutions include optimizing EHR systems, implementing automated dictation or note-taking, employing scribes to reduce documentation burden, and leveraging artificial intelligence to enhance EHR system efficiency and reduce the risk of burnout.

Trial Registration

PROSPERO International Prospective Register of Systematic Reviews CRD42021281173; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021281173
Research on Mode of Sharing Economy in Tourism
Authors: Zhang Ying
Published: April 2024

With the rapid development of Internet technology, the sharing economy model has gradually penetrated into all walks of life. As an important field, tourism has also been deeply affected by the sharing economy model. Based on the in-depth study of the model of sharing economy in tourism, this paper analyzes the specific application, advantages and challenges of sharing economy in tourism, and discusses its future development trend, aiming to provide new ideas and methods for the sustainable development of tourism.