bluuebunny/crossref_metadata_2025 huggingface dataset:
Pretreament neutrophil-lymphocyte ratio (NLR): A felicitous prognostic marker in carcinoma lung
Authors: Sehgal Shailley A. , Malik Garima , Sachdeva Aman , Chauhan Ashok K. , Kaushal Vivek , Kaur Paramjeet , Atri Rajeev
Published: February 2024

ABSTRACTS

Background:

Mechanics of inflammation and oncogenesis are intertwined with each other. Thus, the role of inflammatory markers like neutrophil-lymphocyte ratio (NLR) as a foreteller of lung carcinoma is retrospectively appraised in this study.

Material and Methods:

Retrospective assessment of hospital records of carcinoma lung patients was done between January 2018 and January 2020 and pretreatment NLR was calculated. Median NLR was taken as cut off and thereafter correlation was studied between pretreatment NLR and overall survival, using Kaplan-Meier survival analysis. Cox regression analysis was applied to identify factors affecting survival.

Results:

Study population included 135 eligible patients with median age of 60 years and male to female ratio of 8.6:1. 47.41% patients were of stage III and 52.59% patients belonged to stage IV. The duration of follow-up ranged between 0.5 and 22 months. Median NLR was 3.1 (range, 0.90–11.25) and median overall survival in patients with NLR <3.1 and ≥3.1 was 6 months versus 3 months, respectively (P-value = 0.001). NLR value in nonsmall cell and small cell lung cancer was analyzed separately and showed significant variation in median survival in nonsmall cell lung cancer patients only (P-value = 0.001).

Conclusions:

Study results summarized that pretreatment NLR can be taken as a cheap and easily available predictor of prognosis in carcinoma lung cases and more so in nonsmall cell lung carcinoma cases. Large prospective trials are warranted to further potentiate this fact.
Global and promoter specific hypermethylation of tumor suppressor genes P16, SOCS1, and SHP1 in oral squamous cell carcinoma and oral submucous fibrosis
Authors: Ukey Shweta , Jain Ankit , Dwivedi Shailendra , Vishnoi Jeewan Ram , Chugh Ankita , Purohit Purvi , Pareek Puneet , Elhence Poonam , Misra Sanjeev , Sharma Praveen
Published: February 2024

ABSTRACTS

Aberrant methylation pattern leads to altered gene expression, that is, involved in the transformation of various cancers, including oral squamous cell carcinoma (OSCC). In the present study, an attempt has been made to examine the association of global and promoter-specific methylation of tumor suppressor genes in patients with OSCC and oral submucous fibrosis (OSMF). Promoter-specific methylation of tumor suppressor genes P16, SOCS1, and SHP1 had been studied earlier for their aberrant methylation patterns in other cancers; however, these studies were mainly conducted in-vitro or in animal models, and as such, only a few studies are available on human samples. In the present study evaluation of promoter-specific methylation of genes P16, SOCS1, and SHP1 in 76 patients’ blood and tissue samples was done and compared with methylation of 35 healthy control samples using qPCR. Further, these samples were analyzed for global methylation patterns using ELISA. The results have shown a significant decreasing trend of promoter methylation (OSCC > OSMF > Controls); the methylation indices (MI) were significantly higher in OSCC than in the controls. The median MI of three genes for OSCC were P16MI (0.96), SHP1MI (0.79), and SOCS1 (0.80). Similarly, median MIs for OSMF were P16MI (0.18), SHP1 MI (0.19), and SOCS1 MI (0.5) against controls with MI (0) for each of the three genes. The global methylation %mC values were 1.9, 0.5, and 0.1, respectively. The values of MI and %mC were found to correlate with various risk factors such as tobacco, smoking, and alcohol consumption, which are positively involved in OSMF pathogenesis followed by oral cancer progression. Further, the methylation trend in tissue was reflected in blood samples, proving a window for methylation load to be used as a lesser invasive biomarker. The sensitivity and specificity of methylation load were also found reasonable. Therefore, the current study suggests that there may be a role of global and promoter-specific methylation load in the transition of OSMF to OSCC.
The effectiveness of simulation training in obstetric emergencies
Authors: Tarrahi Mohammad Javad , Kianpour Maryam , Ghasemi Marzeieh , Mohamadirizi Soheila
Published: February 2024

Role of clinical skill training in the formation of skills and professional competencies of midwifery students is important. Hence, the use of “training new methods are essential in clinical settings.” This study aimed at determining the effectiveness of simulation training in obstetric emergencies. In this meta-analysis study, international databases of Web of Science, Scopous, Proquest, and PubMed and Iranian databases such as Irandoc, Magiran, and SID were searched for studies published between 2000 and 2020 using related keywords. Based on the consortium checklist, the full text of the selected articles was reviewed and in case of a specific score, the article was analyzed. The results show that, out of 420 studies after applying the inclusion and exclusion criteria, only nine clinical trial articles were reviewed. Studies were conducted in Iran, the United States, France, China, and Chicago. The results of meta-analysis showed that the simulation training method can be effective in managing midwifery emergencies. Hence, the use of simulation training method can be effective in various areas of learning related to obstetric emergencies.
Factors associated with knowledge of health care workers toward COVID-19 in health facilities West Guji zone, Southern Ethiopia, 2020
Authors: Wayessa Zelalem Jabessa , Wako Wako Golicha
Published: February 2024

BACKGROUND:

Coronavirus pandemic puts healthcare workers (HCWs) at high risk and challenges the abilities of healthcare systems to respond to the crisis. This study aimed to assess the level of knowledge of HCWs and associated factors in West Guji zone public health facilities in southern Ethiopia.

MATERIALS AND METHODS:

A health facility-based quantitative cross-sectional study was undertaken from June 10 to July 10, 2020. Two hundred and eighty-three HCWs were involved in the study using a systematic sampling method. The instrument was pretested on 5% of the sample in Yabello Hospital. Data were analyzed using bivariate and multivariate logistic regression.

RESULTS:

The HCW who had good knowledge was 84.7%. HCWs who had degree holders, masters and above holders, work experience of 2–4 years, and >4 years of experiences, had training on Coronavirus, and medical diseases were significantly associated with good knowledge of Coronavirus.

CONCLUSIONS:

This study indicated that HCWs’ knowledge about the Coronavirus was good. Improving the educational status of HCWs and giving updated training on the Coronavirus will improve HCW's knowledge of the Coronavirus.
Smartphone usage and addiction among undergraduate dental students in Malaysia
Authors: Arora Ankita , Wong Wan Wen , Yee Ng See , Lee Rui Yin , Soe Htoo Htoo Kyaw
Published: February 2024

BACKGROUND:

Behavioral addiction to smartphones is a common phenomenon in the present digital age, wherein indulgence in these devices is compulsive and impacts physical, social, and psychological health of the population. The smartphones effect on a dental student's life is detrimental to their academics, health, and efficiency in providing clinical patient care. To assess use and addiction of smartphones among dental students under six major domains and to compare this based on their gender, ethnicity, and year of study.

MATERIALS AND METHODS:

A cross-sectional study using a validated questionnaire, Smartphone addiction scale was conducted among 349 undergraduate students (N = 349) at a private dental school in Malaysia.

RESULTS:

Overall results are presented as mean scores under six domains with total score as 142.40 (33.65). The total scores compared between two genders did not show statistical difference, however on comparing individual domains, females (25.25) had higher mean score for daily life disturbance (P = 0.013) and males (30.17) for cyberspace-oriented relationship (P = 0.001). Chinese students had higher scores with respect to withdrawal (32.45) and cyberspace-oriented relationship (29.48) as compared to other ethnicities. Year 4 students show higher scores than other years in daily life disturbance (27.44), tolerance (16.81), and overuse (16.51).

CONCLUSION:

Our research presents the extent and pattern of smartphone of usage and addiction among the undergraduate students at a dental school in Malaysia. The indicators of addiction highlighted in the study are pivotal in spreading awareness regarding this overuse and addiction as well as planning further research in this area.
Stability for the complete intersection theorem, and the forbidden intersection problem of Erdős and Sós
Authors: Ellis David , Keller Nathan , Lifshitz Noam
Published: February 2024

A family

\mathcal{F}

of sets is said to be
t-intersecting
if

|A \cap B| \geq t

for any

A,B \in \mathcal{F}

. The seminal Complete Intersection Theorem of Ahlswede and Khachatrian (1997) gives the maximal size

f(n,k,t)

of a

t

-intersecting family of

k

-element subsets of

[n]=\{1,\ldots,n\}

, together with a characterisation of the extremal families, solving a longstanding problem of Frankl.
The
forbidden intersection problem
, posed by Erdős and Sós in 1971, asks for a determination of the maximal size

g(n,k,t)

of a family

\mathcal{F}

of

k

-element subsets of

[n]

such that

|A \cap B| \neq t-1

for any

A,B \in \mathcal{F}

.
In this paper, we show that for any fixed

t \in \mathbb{N}

, if

o(n) \leq k \leq n/2-o(n)

, then

g(n,k,t)=f(n,k,t)

. In combination with prior results, this solves the problem of Erdős and Sós for any constant

t

, except for the ranges

n/2-o(n) < k < n/2+t/2

and

k < 2t

.
One key ingredient of the proof is the following sharp ‘stability’ result for the Complete Intersection Theorem: if

k/n

is bounded away from

0

and

1/2

, and

\mathcal{F}

is a

t

-intersecting family of

k

-element subsets of

[n]

such that

|\mathcal{F}| \geq f(n,k,t) - O(\binom{n-d}{k})

, then there exists a family

\mathcal{G}

such that

\mathcal{G}

is extremal for the Complete Intersection Theorem, and

|\mathcal{F} \setminus \mathcal{G}| = O(\binom{n-d}{k-d})

. This proves a conjecture of Friedgut (2008). We prove the result by combining classical ‘shifting’ arguments with a ‘bootstrapping’ method based upon an isoperimetric inequality.
Another key ingredient is a ‘weak regularity lemma’ for families of

k

-element subsets of

[n]

, where

k/n

is bounded away from 0 and 1. This states that any such family

\mathcal{F}

is approximately contained within a ‘junta’ such that the restriction of

\mathcal{F}

to each subcube determined by the junta is ‘pseudorandom’ in a certain sense.
A construction of the Shephard–Todd group $G_{32}$ through the Weyl group of type $\mathrm{E_6}$
Authors: Bonnafé Cédric
Published: February 2024

It is well known that the quotient of the derived subgroup of the Shephard–Todd complex reflection group

G_{32}

(which has rank

4

) by its center is isomorphic to the derived subgroup of the Weyl group of type

\mathrm{E}_{6}

. We show that this isomorphism can be realized through the second exterior power, and take the opportunity to propose an alternative construction of the group

G_{32}

.
Facial Expression Recognition Based on Well-Known ConvNet Architectures
Authors: Alrimy Taima , Alloqmani Ahad , Alotaibi Abrar , Aljohani Nada , Kammoun Salma
Published: February 2024

The Convolution Neural Network (CNN) is the most widely used deep learning architecture as it has broken most world records for recognition tasks. Facial Expression Recognition (FER) systems that use classical feature-based techniques, especially CNN’s, is best for classifying images. This paper used three CNN-based methods, which are VGG-16, Inception-v3, and Resnet50-V2 network architectures, to classify facial expressions into seven classes of emotions: happy, angry, neutral, sad, disgust, fear, and surprise. The face expression dataset from Kaggle and JAFFE dataset were used to compare the accuracy between the three architectures to find the pretrained network that best classifies models. The results showed that VGG-16 network architecture produced a higher accuracy (93% in JAFFE and 54% in Kaggle) than the other architectures.
Effect of Commercial Probiotics on Growth Performance of Sabaki tilapia, Oreochromis spilurus
Authors: Chithambaran Sambhu , Al Harbi Mamdouh , Ali Ghurab Afnan
Published: February 2024

The use of beneficial bacteria to improve fish health and growth is an innovative method in aquaculture practice.  A study was conducted to test the efficiency of two commercial probiotics, such as Sanolife Pro-W and Protexin Balance on the microbial load in culture water and growth performance of Sabaki tilapia, Oreochromis spilurus in fiber glass tanks (400 liters) for a period of 75 days. Sanolife was supplied at 3ppm in the rearing water daily, and designated as Treatment 1. Protexin was incorporated at the rate of 1ppm in a supplementary feed, containing 35% protein in diet and considered as treatment 2. A control was also maintained without treating with probiotics in culture water or feed. Healthy and uniform size fish (3.1 ± 0.5g) were stocked at the rate of 25peaces/tank and both treatments and control tanks were set on a randomized design and triplicated. Water quality parameters (physical and chemical), microbial load in water, growth performance and body composition (nutrients) of fish were assessed during the culture period. Significant difference (p<0.01) on growth was observed between control and treatments, the highest growth was recorded in Protexin treated fish. Water quality parameters did not show significant variations. Carcass protein and lipid content showed significant difference between control and treatments. Considerable reduction in bacterial population and improved growth were observed in Sanolife Pro W treated water, when compared to Control. The result shows that Sanolife significantly reduce the bacterial population in culture water and Protexin improves the growth of fish. The outcome of the study has great application in the field of tilapia aquaculture sector in the Kingdom.
Bioremediation of Contaminated Soil with Crude Oil Using New Genus and Species of Bacteria
Authors: Mohamed Taher Ahmed
Published: February 2024

In this study, the ability of bacteria presents in soils contaminated with crude oil to degrade petroleum hydrocarbons at the study sites (Al-Fatha and AL-Qayyarah) is investigated. Ten bacterial isolates are isolated from the soils of the study area, collected from different areas of Al-Fatha near the North Refineries in Salah-Din Governorate and AL-Qayyarah Refinery in Nineveh Governorate. These bacterial isolates show uneven growth in the mineral medium prepared with crude oil. Three new bacterial genera and two species are obtained, one of which belongs to the genus Bacillus and the other to the genus Exiguobacterium. The new bacterial isolates are recorded in the National Center for Biotechnology Information (NCBI) for the first time with the following numbers:(LC596402, LC596403& LC596406) for the genus (AM-I-1, AM-I- 2, and AM-I-5), respectively and (LC596404, LC596405) for the species (AM-I-3 and AM-I-4), respectively. The results show the ability of the isolates (AM-I-1, AM-I-2, AM-I-3, AM-I-4, and AM-I-5) to consume Polyaromatic Hydrocarbons (PAHs) compounds in the mineral medium prepared with crude oil with different concentrations and degrees, temperatures and pH conditions. The optimum conditions are pH 7, temperature 40°C and 2% crude oil concentration with a period of 12 days. The bacteria (AM-I-3) has outperformed the rest of the bacterial isolates with a consumption of (PAHs) compounds of 86.5%, followed by bacterial isolates and their mixture with a consumption rate of (84.42%, 78.19%, and 75.20%) (AM-I-1, AM-I-4, & mix of isolates), respectively.
Morphological Description of Ocean-Collected Portunus sp. First Crab (Crustacea: Brachyura: Portunidae) from the Obhur Creek, Red Sea, Saudi Arabia
Authors: Austin Anand , N.M. Naqoor Nada
Published: February 2024

Twenty-one specimens of Portunus sp. first crab were obtained from plankton samples collected from the Obhur Creek, Central Red Sea, Saudi Arabia. These specimens have been morphologically described herein. The setal patterns of the first crabs of the present specimens were compared with those of the first crabs of P. sanguinolentus. Presence of two to three rows of setae on the coxa of maxillule and coxa and basial of the first maxilliped are found in both the species of Portunus first crabs compared herein. These features seem to be taxonomically significant as these features are found in one of the other genera of Portunidae – Thalamita.
Fight and Contemplation. The Towianists amid the European Revolutions of 1848
Authors: Dalla Grana Giulio
Published: February 2024

The aim of the article is to show the European diffusion of an esoteric doctrine that originated in Lithuania in the nineteenth century and its circulation during the European uprisings of 1848. The article focuses on a case study of heterodox Catholic thought promoted by Andrzej Towiański. Towianism was diffused in Central and Eastern Europe and consolidated its presence in Western and Southern Europe. The Towianists acted to influence politics and participated in several key historical events of the nineteenth century. Using archival sources, the article investigates the relationship between Romantic nationalism and esotericism, its transnational nature, and its contribution to a turning point in European history.
Spiritual Art in the Context of Transdisciplinarity and Transculturalism
Authors: Elezović Nadežda
Published: February 2024

This paper deals with the emergence and meaning of the term spiritual in modern, postmodern, and contemporary art with a particular focus on its transdisciplinary and transcultural aspects. The problem develops because of the hitherto neglected involvement of the spiritual in the development and expansion of the modernity program in recent European art history, with a particular focus on recent research redirected from traditional positions of national context to the transformation of visual language and transcultural character of some movements in modern art. This work covers the meaning and development of transdisciplinary spiritual art, the non-national character of its production, and the internationalization of its practice, focusing on the link with the reduction, abstraction, and tendencies of media dematerialization. It concludes with a review of innovative aspects of spiritual art and its apolitical character in times of intense social change.
Marian Grużewski and the “Homocratic Movement” in the Archives of the Polish Communist Department of Security
Authors: Krok Tomasz
Published: February 2024

This paper concerns Marian Grużewski (1885–1963), a spiritist painter, psychic medium and occultist associated with the Polish Metapsychic Society, who created homocracy, a socio-political movement based on occult and esoteric foundations, after the Second World War. The article discusses and analyses the most important features and standpoints of homocracy through materials (internal statutes and personal notes) confiscated by the Polish communist Security Service. The paper also describes a secret investigation against Grużewski and his supporters, which resulted in their arrest and conviction on charges of attempting to overthrow the People’s Republic of Poland.
Selective antibody deficiency syndrome, response to vaccines, diagnosis, and treatment
Authors: Daniel Alonso-Bello César , Leticia Hernández-Nieto , Vivian Moncayo-Coello Carol , Hernández-Silva Graciela , Gloria Castillo-Narváez , Jaime Mellado-Ábrego , Diego Ballesteros-González , Berenice Ríos-Núñez Elida , David Rico-Rojas , Isabel Rojo-Gutiérrez María
Published: February 2024

Selective antibody deficiency syndrome (SAD), is a primary immunodeficiency in which immunoglobulin levels remain normal, but there is a reduced response to polysaccharide antigens after vaccination. SAD is recognized by the International Union of Immunology Societies as a primary immunodeficiency of unknown genetic cause. Patients with SAD are highly susceptible to severe respiratory tract infections with encapsulated bacteria. The infections found in SAD are similar to other antibody deficiencies; patients often present with recurrent upper and lower respiratory tract infections, otitis media, and sinusitis. The treatment of this pathology is based on preventing recurrent infections by known microorganisms, and in the case of serious infections, the use of intravenous or subcutaneous immunoglobulin.
COVID-19 in the post-vaccination era: Who is at risk of severe disease?
Authors: Daniel Alonso-Bello Cesar , Edgar Pérez-Barragán , Vivian Moncayo-Coello Carol , Isabel Rojo-Gutiérrez María
Published: February 2024

Vaccination against SARS-CoV-2 began in December 2020 and with this strategy, the course of the pandemic would be modified. BNT162b2 (Pfizer–BioNTech), mRNA-1273 (Moderna), and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) were the main vaccines that demonstrated a reduction in hospitalization and death from SARS-CoV-2 in clinical trials. Post-vaccination infection by COVID-19 is called breakthrough infection. Breakthrough infection is more frequent in health workers, and smokers, and critical illness is more frequent in patients with advanced age, and cardiovascular disease. Following vaccination efforts around the world, the incidence of severe COVID-19 infection has decreased, declaring the end of the pandemic by the World Health Organization. However, efforts to keep vaccination active, especially in at-risk populations, must continue.
Selectively depleting the energy of cancer cells: A new therapeutic paradigm
Authors: Warenius Hilmar M
Published: February 2024

Over the past fifty years the somatic mutation theory of cancer has emerged as the most successful explanation of the molecular phenotype of human cancer cells. Normal non-mutated genes may, however, also play a role in carcinogenesis. In particular these may contribute to aerobic glycolysis and the potential interaction of PKM2 and Cdk4 in helping the nascent cancer cell avoid apoptosis by the interaction of their respective amino acid sequences: anionic SDPTEA and cationic PRGPRP. It is proposed that cancer first occurs in normal tissues cells which, as part of the premalignant phenotype have switched from PKM1 to PKM2 expression, and this phenotype persists as cancers age and further molecular biological mechanisms to avoid apoptosis and encourage aerobic glycolysis emerge. PRGPRP and several congeners have been shown to kill a wide range of in vitro cancers by necrosis by producing a fall in ATP without harming normal diploid cells. The ATP depletion is suggested to result from inhibition of aerobic glycolysis and has resulted in the first therapeutic agent that globally selectively kills cancer cells by depriving them of energy.
Stem cell secretome-mediated alleviation of scalp psoriasis: A case report
Authors: Mahmood Anjum , Somani Naman , Patel Divyang , Mishra Rangnath , Srivastsva Anand
Published: February 2024

Scalp psoriasis, a skin condition characterized by red, thickened (erythematous), well-demarcated patches or plaques with overlying silvery-white scales, affecting part or all of the scalp, is an autoimmune disease accompanied by itchy skin. The disease is associated with faulty functioning of adaptive and innate components of immune systems. The key proinflammatory cytokines mediating immunopathology of psoriasis are IL-17 and IL-23 which promote proliferation of Th 17 cells which in turn induce proliferation of keratinocytes leading to the disease. Standard management of psoriasis primarily targets the disease by suppression of inflammation using steroid based drugs. However, these are not enough to cure the disease. In recent years researchers have demonstrated the use of mesenchymal stem cells (MSCs) in treating autoimmune disorders and skin disorders. MSCs mediate skin regeneration by a plethora of mechanisms including immune modulation, angiogenesis, proliferation of mediator cells like fibroblasts, and by inhibition of proinflammatory pathways. The paracrine factors secreted by MSCs in surrounding environment like growth factors, cytokines, chemokines, and other signaling and regulatory molecules, act as key molecules in mediating anti-inflammatory responses. Here we describe a case report following the treatment of a patient suffering from scalp psoriasis using MSC- secreted molecules in the conditioned media. Both silvery scales and plaques on the scalp were significantly reduced within 4 weeks of topical application of the conditioned media. The patient remained disease free for 3 years of follow up. Our current results are in good agreement with those of our previous report where we reported complete amelioration of scalp psoriasis following the topical application of the conditioned media.
Citizen science data on urban forageable plants: a case study in Brazil
Authors: Soares Filipi Miranda , Ferreira Pires Luís , Garcia Maria Carolina , Coradin Lidio , Ghilardi-Lopes Natalia Pirani , Silva Rubens Rangel , de Carvalho Aline Martins , Gavai Anand , Bouzembrak Yamine , Maculan Benildes Coura Moreira dos Santos , Koffler Sheina , Montedo Uiara Bandineli , Drucker Debora Pignatari , Santiago Raquel , de Carvalho Maria Clara Peres , Lima Ana Carolina da Silva , Gabriel Hillary Dandara Elias , de França Stephanie Gabriele Mendonça , de Almeida Karoline Reis , dos Santos Bárbara Junqueira , Saraiva Antonio Mauro
Published: February 2024

This paper presents two key data sets derived from the Pomar Urbano project. The first data set is a comprehensive catalog of edible fruit-bearing plant species, native or introduced to Brazil. The second data set, sourced from the iNaturalist platform, tracks the distribution and monitoring of these plants within urban landscapes across Brazil. The study includes data from the capitals of all 27 federative units of Brazil, focusing on the ten cities that contributed the most observations as of August 2023. The research emphasizes the significance of citizen science in urban biodiversity monitoring and its potential to contribute to various fields, including food and nutrition, creative industry, study of plant phenology, and machine learning applications. We expect the data sets presented in this paper to serve as resources for further studies in urban foraging, food security, cultural ecosystem services, and environmental sustainability.
Climate Resilient Cities Assessing Differential Vulnerability to Climate Hazards in Urban India
Authors: Rangwala Lubaina , Chatterjee Sudeshna , Agarwal Avni , Khanna Bhanu , Shetty Bina , Palanichamy Raj Bhagat , Uri Ike , Ramesh Ananya
Published: February 2024

This report introduces the Climate Hazard and Vulnerability Assessment (CHVA) framework, which is developed as an accessible tool to focus on the hazards and social factors that create differential vulnerability to climate change in cities. To analyse differential vulnerability, CHVA is divided into three parts: Hazard Identification and Assessment, Exposure Analysis, and Vulnerability Assessment. Using official city-level data that can in some cases be supplemented with alternative local data sources, the CHVA assesses both hazards and the vulnerability of people and critical infrastructure to give a robust and in-depth understanding of urban vulnerability.
Outras vasculites: vasculite associada ao ANCA por droga, Cogan, Susac e primária do sistema nervoso central
Authors: Teixeira Carlos Eduardo Garcez , Del Rio Ana Paula Toledo , Sachetto Zoraida
Published: February 2024

As vasculites sistêmicas compreendem um grupo de doenças inflamatórias que afetam os vasos sanguíneos com consequências graves, incluindo isquemia tecidual, anomalias estruturais, como aneurismas e dissecções e lesões orgânicas. As diferentes formas são normalmente classificadas de acordo com o tamanho do vaso. Nesta revisão são discutidas outras formas de vasculites sistêmicas, raras, como as vasculites associadas ao ANCA por droga, Cogan, Susac e primária do sistema nervoso central.

Unitermos: vasculite associada ao ANCA por droga; Cogan; Susac; vasculite primária do SNC.
Mimetizadores da esclerose sistêmica
Authors: Santos Marília Paula de Souza , Teixeira Carlos Eduardo Garcez , Del Rio Ana Paula Toledo
Published: February 2024

A esclerose sistêmica (ES) é uma doença heterogênea, mas que tem o espessamento cutâneo como característica mais marcante. Diversas afecções autoimunes, inflamatórias, metabólicas entre outras podem evoluir com espessamento cutâneo, o que torna necessário o diagnóstico diferencial. Essas doenças são consideradas mimetizadores da ES e, dentre elas, destacamos a esclerodermia localizada, a fasciíte eosinofílica, o escleromixedema, a fibrose sistêmica nefrogênica, o escleredema de Buschke e a síndrome POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes). A diferenciação pode ser uma tarefa complexa, mas reconhecer o padrão de envolvimento cutâneo, manifestações associadas e fatores de risco permite direcionar e melhorar a abordagem do paciente com espessamento de pele. Nesse contexto, a ausência de fenômeno de Raynaud, de anticorpos específicos ou de alterações na capilaroscopia são grandes pistas diagnósticas. Em nossa revisão, abordaremos algumas doenças que têm o espessamento de pele como sinal clínico relevante e suas principais características que permitem estabelecer de forma mais apropriada o diagnóstico correto e, consequentemente, o tratamento e prognóstico.

Unitermos: esclerose sistêmica; esclerodermia; escleromixedema; fasciíte eosinofílica; escleredema de Buschke.
Certolizumab pegol en artritis reumatoidea severa. Evidencia de la vida real en una cohorte argentina: Logro de objetivos (T2T) a 3 meses y factores predictivos.
Authors: Garcia Salinas Rodrigo , Magri Sebastian , Ruta Alvaro
Published: February 2024

Introducción: Certolizumab pegol (CTZ) es un agente biológico inhibidor de TNF-alfa, ha demostrado eficacia en el control de la AR. La identificación de factores predictivos para el éxito del tratamiento y la evaluación de su eficacia en un entorno de práctica clínica real son cruciales para la toma de decisiones. Objetivo: Evaluar la respuesta CTZ en pacientes con AR en una cohorte de vida real, midiendo la reducción en DAS 28, HAQ, frecuencia de remisión y LDA a los tres meses, identificar factores predictivos y evaluar la reducción en el uso de corticoides. Métodos: Estudio observacional prospectivo incluyó pacientes mayores de 18 años con AR, que comenzaron CTZ y tuvieron seguimiento a los tres meses. Se registraron datos demográficos, clínicos, comorbilidades, tratamientos y actividad de la enfermedad. Resultados: De 2092 pacientes con AR tratados con CTZ entre 2016 y 2021, el 90% tenía mal pronóstico y el 60% alta actividad. De 1673 pacientes seguidos a tres meses, se observó una reducción en DAS 28 (-1.9) y HAQ (-0.63). A los tres meses, el 10.5% alcanzó remisión y el 40% LDA. Factores predictivos para remisión incluyeron edad (OR: 0.97) y DAS 28 (OR: 0.58); para LDA, edad (OR: 0.97), DAS 28 (OR: 0.61), CTZ de primera línea (OR: 1.6) y HAQ (OR: 0.61). Además, hubo una reducción en el uso de glucocorticoides (-3.1 mg prednisona). Conclusiones: CTZ es efectivo en AR, destacando la selección de pacientes y un enfoque temprano en el tratamiento. Este estudio respalda la eficacia de CTZ.
PENYULUHAN TUBERKULOSIS PARU KEPADA MASYARAKAT LINGKUNGAN HAMPARAN PERAK KECAMATAN DELI SERDANG
Authors:   Universitas Methodist Indonesia, Situmeang Ivonne Ruth Vitamaya Oishi , Simanjuntak Maestro B. U. , L. Tobing Paul S. M. , Sinurat Suryati , Harefa Alowadodo , Simanullang Okkasa Obadiah
Published: February 2024

The aim of community service activities is to implement community service in implementing the Tri Dharma of higher education as well as contributing ideas and transferring knowledge to mothers, fathers, children and youth. This service activity was carried out on March 24 2022, with the material Lung Tuberculosis. This topic is really needed in order to provide information and knowledge about Pulmonary Tuberculosis, starting from how to prevent and treat Pulmonary TB patients. This topic was deliberately chosen considering that currently TB is still the biggest health problem in the world, apart from that, our country, Indonesia, has the second highest rate of TB. Therefore, the role of medical personnel is very important in providing education to the public to behave in a clean manner at home and around the home environment, where this activity aims to reduce the risk of transmission and infection of Pulmonary Tuberculosis.
PELATIHAN PERENCANAAN BERBASIS DATA PADA PENGAWAS SEKOLAH, KEPALA SEKOLAH DAN GURU MENGGUNAKAN METODE INDENTIFIKASI, REFLEKSI DAN BENAHI (IRB) SECARA DARING
Authors:   STMIK Kaputama, Fauzi Achmad , Rahayu Rizka Putri ,   Universitas Kholisatur Rahmi, Khair Husnul ,   STMIK Kaputama, Maulita Yani ,   STMIK Kaputama
Published: February 2024

Data-based planning training is carried out online based on various sources which can be used to carry out or prepare an agenda for future activities and budgets. The data-based planning training activity was carried out online for two days. This implementation started with the experience of the school principal sharing his experience with the education unit in planning and compiling activities and making budgets at the school, then the facilitator provided reinforcement for data mining from the independent teaching platform (PMM ), Education Report Card Platform as well as through data sourced from the North Sumatra Education Quality Assurance Center (LPMP). Then the facilitator reflects on the training on the material that has been explained. On the second day of implementation, each educational unit grouped to discuss and fill in the evaluation sheet, then carried out identification, reflection and improvement in planning activity plans and preparing budgets for the unit, then apart from that, the educational units held discussions to make follow-up plans starting from the date, unit involved and the media used. Next, reflect on your experience at school, then work on an evaluation worksheet that is synchronized with the Identification worksheet, then a reflection worksheet and a fix worksheet, then the education unit finishes working on an activity plan that comes from several data and can prepare a budget that is planned for the long term.
PENYULUHAN DEMAM BERDARAH DANGUE (DBD) KEPADA REMAJA GMI MANNA MARTURIA TANJUNG SARI
Authors:   Universitas Methodist Indonesia, Damanik Irene R. Tua , Simanjuntak Harry C. , Panjaitan Budi J. , Veronika Agustina , Pakpahan Edwin A. , Sihombing Ferry G. , Yosephine Kathleen I. , Sitepu Elvindo W. A. , Siagian Fevi Yolanda , Br Nainggolan Nova A. , Nainggolan Hotlin C. , Br Aruan Sella A. , Tarigan Billy C. , Zandroto Sofi A. , Joris Letisya Feronika
Published: February 2024

Community Service is a form of student activity which is a way of student interaction with the community and the surrounding environment. The topic taken was Dangue Hemorrhagic Fever (DHF), this topic was deliberately chosen considering that currently it is the rainy season where rainfall is very high. Education about Dengue Hemorrhagic Fever (DHF) is important to increase public awareness about the prevention and management of this disease. The aim of FK-UMI Community Service is to provide counseling and provide education to the public regarding dengue fever. The method used is to convey public education information using projectors and interactive media. Conclusions obtained. With this health education, teenagers will understand how to improve their quality of life and maintain a clean environment to avoid dengue fever.
Osteosarcoma metastasis in bone of a mixed breed dog – case report
Authors: Rozolen Juliana Moreira , Teixeira Tarso Felipe
Published: February 2024

Osteosarcoma (OSA) is one of the main types of bone cancer in dogs, with an increased prevalence. Its aggressive behavior is attributed to the high incidence of metastasis and rapid evolution. The aim of this study was to report the case of an eight-year-old mongrel male dog admitted to the veterinary clinic with signs of pain and lameness. A tumor was found in the left radioulnar region, which was confirmed by the radiographic finding of bone lysis. There were no metastases in the lung and other organs. After resection, the tumor was diagnosed as osteoblastic productive OSA. Three months later, the patient developed the same symptoms in right hindlimb. A radiograph of the femur showed bone lysis with loss of trabecular pattern, suggestive of bone tumor, and there were radiopaque nodules in the lung. The animal died after twenty days; affected tissue fragments were collected at necropsy. Histopathological analysis confirmed that it was an osteoblastic OSA. It is known that metastasis of osteosarcoma in bone tissue is rare.
Epidural anesthesia in Chinchilla lanigera – case report
Authors: de Santana Marques Jenifer , Menezes Renata Cristina , Corrêa Devito Fernanda , Quirico Igor Alexandre
Published: February 2024

Chinchillas are small mammals of the order Rodentia and family Chinchillidae. The species Chinchilla lanigera is the most commonly bred; individuals of this species are often used as pets. Orthopedic trauma in small rodents often results from domestic accidents such as falling objects, slamming doors and trampling by other animals. First aid consists in controlling the state of collapse, respiratory changes, abdominal disorders and bleeding. This study reports the anesthetic protocol developed for a Chinchilla lanigera undergoing an amputation surgery of the pelvic member due to an exposed fracture of the femur. The protocol used epidural anesthesia and proved to be safe, as it allowed stabilization of the physiological parameters, rapid recovery and absence of pain trans- and postoperatively.
Myxomatosis in rabbit – a literature review
Authors: Bruno Sávio Freire , Marques Paulo Roberto de Souza , Tortelly Rogério
Published: February 2024

Mixomatosis is an infectious-contagious disease of compulsory notification that affects rabbits and is caused by a virus from the Poxviridae family (Myxoma virus), trasmitted directly or indirectly through vectors. It is very important globally because of its endemicity and high mortality rate. Symptoms are bilateral blepharoconjunctivitis, noduli and generalized edema over the whole body, especially on the face, nose and ears, which makes the head of the animal resemble that of a lion. Diagnosis is mainly based on the clinical signs, aided by anatomopathological findings. Confirmation can be achieved through electron microscopy, ELISA, complement fixation test (CF), polymerase chain reaction (PCR) and viral isolation. There is no treatment after the infection and most animals die. The most important prophylactic measure is vaccination.
Tetanus in dogs and cats – a review
Authors: Azevedo Voorwald Fabiana , Tiosso Caio de Faria , Cardilli Diogo José , Ribeiro Cardoso dos Santos Izabella , Toniollo Gilson Hélio
Published: February 2024

Tetanus is a disorder caused by the action of the painfully and potentially fatal neurotoxin tetanospasmin, which is produced under anaerobic conditions during the vegetative growth phase of Clostridium tetani. Dogs and cats have natural resistance due to the relative inability of the toxin to penetrate and bind to nervous tissue. Active immunoprophylaxis is not recommended to these species due to the high cost of vaccine production compared to the low prevalence of affected animals. The sporadic occurrence of tetanus in small animals leads to lack of practical and theoretical knowledge to allow immediate presumptive diagnosis, which in turn retards the correct lifesaving clinical measures necessary to patient survival. This article aims to review, update and discuss the physiopathology, clinical signs, methods of diagnosis, possible complications and tetanus prognosis in dogs and cats.
Adrenalectomy in dog with hyperadrenocorticism unresponsive to treatment with trilostane – case report
Authors: de Magalhães e Corrêa Sílvia Verônica , Nishiya Adriana Tomoko , Machado Fabrício Lorenzini Aranha
Published: February 2024

Hyperadrenocorticism (HAC) is an endocrine condition resulting from elevated serum glucocorticoid levels. When endogenous, it may be pituitary-dependent or adrenal-dependent. Literature reports suggest that cases of adrenal-dependent unilateral HAC without metastases be treated surgically, but this conduct is not routine in Brazil yet. A review of studies published in the last decades shows, however, significant reduction in the perioperative mortality rate of such patients. The current study reports the case of a crossbreed 10-year-old female dog with adrenal-dependent HAC that was unresponsive to medical treatment and was submitted to adrenalectomy. We emphasize both preoperative and post-operative care measures that contributed to the success of the surgery.
Radiographic and tomographic features of elbow dysplasia – a literature review
Authors: Sendyk-Grunkraut Alessandra , Villamizar-Martinez Lenin Arturo , Outi Baroni Carina , Maciel Zardo Karen , Matsunaga Martin Claudia , Brandão de Campos Fonseca Pinto Ana Carolina
Published: February 2024

Elbow dysplasia (ED) is a frequent condition in young and young adult dogs and one of the most frequent causes of thoracic limb lameness. The main causes of ED are: ununited anconeal process (UAP), fragmented medial coronoid process of the ulna (FMCP), osteochondrosis/osteochondritis dissecans of the distomedial aspect of the humeral trochlea (OH) and articular incongruity (AI). Radiographic diagnosis of ED poses many challenges to the clinician. OA and AI can be easily detected in radiographic exams, but OH and FMCP may demand further analysis with other imaging modalities for the final diagnosis to be established, such as computed tomography and magnetic resonance imaging. The aim of this review is to discuss the radiographic and tomographic features of ED, as well as the advantages of computed tomographic images in relation to the radiographic exam.
Use of the diuretic torsemide in the treatment of dogs with congestive heart failure – a three-case report
Authors: Gabriel Filho Samuel José
Published: February 2024

Congestive heart failure is a common complication due to the progression of chronic atrioventricular valve disease. The treatment aims to ameliorate the clinical signs, improve quality of life and lifespan, and includes inhibitors of the angiotensin converter enzyme, vasodilators and positive inotropes, in addition to diuretics. The latter have been considered the cornerstone in the treatment of congestive signs. Furosemide is the most frequently prescribed loop diuretic. Chronic incorrect usage or high doses of the drug may promote the loss of diuretic function, known as diuretic resistance. Torsemide is a loop diuretic that has shown satisfactory results and superiority in comparison to furosemide. This paper reports three cases of dogs diagnosed with refractory congestive heart failure, in which furosemide was replaced by torsemide.
Bronchomalacia in dogs – a report of two cases
Authors: Ferian Paulo Eduardo , Carneiro Rubens Antônio
Published: February 2024

Primary bronchomalacia is a respiratory condition characterized by weakness of the structural components of the bronchi, with consequent collapse of these airways. The morphologic abnormality results in respiratory disease characterized by chronic cough and, in certain cases, respiratory distress. Although the disease was recognized long ago in human beings as a primary respiratory disorder, the condition has only recently been reported to cause respiratory disease in dogs. For this reason, epidemiological aspects, clinical and complementary diagnoses and therapeutic methods are still widely unknown. This paper aims to describe two cases of primary bronchomalacia in dogs, with clinical features, complementary diagnosis and treatment of one of these patients. This is the first report of the disease in Brazil.
Malignant intraocular teratoid medulloepithelioma in a dog – a case report
Authors: Zagato Urbani Paula , Perlmann Eduardo , Padovani De Biaggi Christianni , Intelizano Tatiane Regina , Souza Sergio dos Santos
Published: February 2024

Although there are several intraocular tumors reported in animals, the malignant teratoid medulloepithelioma is an intraocular tumor which originates from the primitive medullary epithelium and it is rare both in animals and humans. This tumor usually occurs during childhood; nonetheless, some reports have shown its occurrence in the elderly. This tumor development is slow and it is locally aggressive, but its metastatic character is low. This article describes the case of a malignant intraocular medulloepithelioma in a twelve-year-old male stray dog with a history of buphthalmic glaucoma, which had been treated medically five years before, and returned with an intraocular mass. After enucleation, the material was sent to histopatological examination and subsequent immunohistochemistry to confirm the diagnosis. A year after the procedure the animal is healthy and there are no metastases.
KEPEMIMPINAN, LINGKUNGAN KERJA TERHADAP STRES DAN PERFORMANSI KARYAWAN RESTORAN MENGGUNAKAN PLS
Authors: Abnur Asman , Wibowo Agung Edy , A.Nasution M.Nur
Published: February 2024

ABSTRAKSI 

Berlalunya wabah Covid-19 telah memberi ruang dan waktu bagi industri pariwisata untuk bangkit dan berkembang kembali. Dewasa ini pariwisata telah menjadi bagian dari sekian aspek yang diprioritaskan oleh beberapa negara dalam meningkatkan pendapatan sebuah negara. Pariwisata dapat diberikan pengertian sebagai aktivitas seseorang dari suatu tempat ke tempat yang berbeda dengan tujuan untuk berkunjung, singgah sementara waktu yang tidak terlalu lama dengan motif untuk menikmati lokasi kunjungan dalam wilayah tersebut. Bertumbuhnya kegiatan industry pariwisata tentu saja akan memberikan dampak bagi pertambahan laju atau peningkatan pendapatan suatu negara. Pada kenyataanya banyak negara membuktikan bahwa .sektor pariwisata mampu mendorong dan memberi efek penambahan perkapita sebuah negara dan memberikan daya dorong bagi ekonomi dan industri turunan pariwisata seperti munculnya industri kerajinan, industri dan produk cinderamata, Munculnya ragam dan bentuk model penginapan seperti homestay, guest  house, dan unit unit usaha kecil menengah yang berhubungan dengan pariwisata seperti kuliner lokal, dan jajanan makanan khas daerah..

Tujuan dari studi ini adalah untuk mengetahui dan menganalisis  kepemimpinan, lingkungan kerja terhadap stress kerja, dan pengaruh masing masing variabel tersebut terhadap performasi karyawan. restoran Sederhana dan Nasi Kapau yang terdapat di Kota Batam. Responden yang digunakan untuk mendukung studi ini sebanyak 117 partisipan. Hasil  penelitian menunjukan bahwa  kepemimpinan berpengaruh signifikan terhadap stres, lingkungan kerja  berpengaruh signifikan terhadap performansi, lingkungan kerja berpengaruh signifikan terhadap stres dan stres berpengaruh signifikan terhadap performansi