bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultural Characteristics of Rhizoctonia solani Causing Sheath Blight of Rice
Authors: Sharma Sonu , Tripathi S. K. , Kashyap Vijay Kumar , Rajput Bharti , Kumar Bahrat
Published: November 2023

Sheath blight of rice caused by Rhizoctonia solani Kuhn is emerging as a very destructive disease causing heavy yield losses. The present study was conducted at Department of Plant pathology, JNKVV, College of Agriculture, Rewa, (M.P.) with eight culture media  viz., Potato Dextrose Agar (PDA), Czapek’s Dox Agar (CDA),Richards medium (RMA), Corn Meal Agar (CMA), Oat meal agar (OMA), Rice leaf extract agar (30%),Rice seed extract agar (10%) and Rice seed extract (10%)+ (2%) sucrose were evaluated against R. solani. It can be concluded that Potato dextrose agar (88.0 mm) and Czapek’s dox agar (87.7 mm) medium supported maximum mycelial growth of R. solani isolated from rice. Whereas, least mycelial growth (75.8 mm) was observed in Rice seed extract agar and Richards agar medium. Mycelial growth was excellent fast, abundant and off white on Potato dextrose agar. Whereas it was fast, abundant and on Czapek’s dox agar. Sclerotia of the fungus initiated within 3 - 4 days in different culture media. Maximum number of sclerotia was produced in Oat meal agar (54.0) closely followed by Potato dextrose agar (51.2) and Czapek’s dox agar (44.6). Maximum weight of 10 sclerotia was recorded in potato dextrose agar (1030.6 mg) followed by Czapek’s dox agar (920.3 mg) and Oat meal agar (884.7 mg). Maximum size of sclerotia were formed in Potato dextrose agar followed by Rice seed extract agar and Corn meal agar.
Effect of Liquid Organic Manures on the Performance of Sweet Corn (Zea mays L. saccharata)
Authors: Sushmitha M. , Kumar B. Rajendra , Jyothi P. Amara , Gurumurthy P.
Published: November 2023

A field experiment was conducted during rabi 2022 at Block D of the College Farm, Agriculture College, Naira. The experiment was laid out in Split-plot design with three main plots.M1:100% RDF (180-60-60 NPK Kg ha-1) + FYM @10 t ha-1, M2:75% RDF (135-45-45 NPK Kg ha-1) + FYM @10 t ha-1. M3:0% RDF- Control and four sub-plotsS1: Liquid azospirllum+PSB+KRB+ZnSB+@1.25 L ha-1 each at knee high stage, S2: Vermiwash spraying twice @5% at knee high and tasseling to silking stages, S3: Panchagavya spraying twice @3% at knee high and tasseling to silking stages andS4: Drava Jeevamrutham spraying twice @10% at knee high and tasseling to silking stages Results revealed that 100% RDF (180-60-60 NPK Kg ha-1) + FYM @10 t ha-1 (M1) recorded maximum fresh cob yield (16409 kg ha-1) and stover yield (17481 kg ha-1). Among the subplots: Liquid azospirllum+ PSB+ KRB+ ZnSB+@1.25 L ha-1 (S1) recorded maximum fresh cob yield (14091 kg ha-1) and stover yield (15623 kg ha-1). The interaction effect of different doses of RDF and liquid biofertilizers on fresh cob yield, stover yield and HI was found to be nonsignificant. Hence, it can be concluded that different doses of RDF and liquid biofertilizers are advantageous for weet corn cultivation on sandy loam soils of North costal region.
Effect of Pearl Millet (Pennisetum glaucum L.) to Split Application of Nitrogen at Different Stages under Irrigated Conditions
Authors: Yadav Sapna , Sharma P. K. , Kumar Amit
Published: November 2023

A field experimentation was conducted at carried out during kharif 2022 at research farm, Vivekananda Global University, Jaipur. The objectives were to study the effect of nitrogen and split application of nitrogen on growth and productivity of pearl millet. The experiment consisted of 9 treatment combinations comprising three levels of nitrogen (100% RDN (60 kg N/ha), 125% RDN (75 kg N/ha) and 150% RDN (90 kg N/ha) with three levels of split application of nitrogen (Full dose of N at sowing, ½ N at sowing + ½ N at tillering (20-25 DAS) and 1/3 N at sowing + 1/3 N at tillering (20-25 DAS) + 1/3 N at boot stage (35-40 DAS)). The experiment was laid out in split plot design and replicated thrice. The result revealed that levels of nitrogen significantly influenced highest plant height (cm), dry matter accumulation at different stages, chlorophyll content in leaf at 60 DAS, number of effective tillers per plant, length of ear, test weight, grain, stover, biological yields, NPK content and their uptake and protein content with the application of 125% RDN (75 kg N/ha) over 100% RDN (60 kg N/ha). Significantly higher net return (Rs 56315/ha) and highest B:C ratio (2.03) were also obtained with 125% RDN (75 kg N/ha). Further, the split application of nitrogen significantly influenced plant height (cm), dry matter accumulation, chlorophyll content in leaf at 60 DAS, number of effective tillers per plant, length of ear, test weight, grain, stover, biological yields, NPK content and their and protein content with the application of 1/3 N at sowing + 1/3 N at tillering (20-25 DAS) + 1/3 N at boot stage (35-40 DAS) over full dose of N at sowing and ½ N at sowing + ½ N at tillering (20-25 DAS). This treatment also increased significantly net return (Rs 67552/ha) and B:C ratio (2.45) rest of the treatments
PENERAPAN MULTI-CRITERIA DECISION MAKING DALAM PENGAMBILAN KEPUTUSAN SISTEM PERAWATAN
Authors: Rahardjo Jani , Yustina Rosa , E. Stok Ronald
Published: November 2023

The selecting of the right maintenance system strategy can give an optimum result in achieving productivity of a production process. The right method is needed in choosing this strategy, so that the decision-maker can make the right decision.

Methods used in the selecting of the maintenance system strategy is Multi Criteria Decision-Making, especially Analytical Hierarchy Process (AHP), and Heuristic Method. Heuristic method is used to decide the most critical criteria in the choosing of processing system strategy.

Abstract in Bahasa Indonesia :

Pemilihan strategi sistem perawatan yang tepat dapat memberikan hasil yang optimum dalam pencapaian produktivitas suatu proses produksi. Didalam pemilihan strategi ini diperlukan suatu metode yang tepat agar decision maker dapat membuat keputusan yang tepat.

Metode yang digunakan dalam pemilihan strategi sistem perawatan adalah Multi-Criteria Decision Making, khususnya Analytical Hierarchy Process( AHP) dan Metode Heuristic.Metode Heuristic digunakan untuk menetukan kriteria yang paling kritis dalam pemilihan strategi sistem perawatan.

Kata kunci: analytical hierarchy process, perawatan
STUDI TENTANG PETA KENDALI p YANG DISTANDARISASI UNTUK PROSES PENDEK KUALITAS
Authors: Octavia Tanti , Prabudy Lia Magdalena , Prajogo Daniel Indarto
Published: November 2023

Attribute control charts especially p charts have been used widely for statistical process of attribute characteristics. In many applications, however it is neither possible nor practical to obtain sufficient subgroups to estimate accurately the control limits for the conventional p chart. This may occur when the production process is characterized as being a short run. One short run situation is a production run which produces items in a short period of time.

In this article we describe the standardized p chart that the beyond control limit probabilities of proposed chart are closer to 0.135%

Abstract in Bahasa Indonesia :

Peta kendali atribut khususnya peta kendali p banyak digunakan untuk mengendalikan proses yang berkarakteristik atribut. Pada penerapannya proses produksi yang membutuhkan waktu relatif pendek mengakibatkan subgrup yang diperoleh terbatas jumlahnya, sehingga peta kendali p yang terbentuk tak memungkinkan untuk dianalisa.

Dalam artikel ini akan diulas sebuah standarisasi peta kendali p yang diusulkan dengan mempertimbangkan probabilitas data yang keluar dari batas kendali.

Kata kunci: ARL0 , ARL1, koreksi kontinuitas
PENGEPAKAN PIPA BERAGAM DIAMETER KE DALAM SATU KONTAINER DENGAN MENGGUNAKAN SOLUSI HEURISTIK ALGORITMA GENETIKA
Authors: L. Singgih Moses , Untung Sundoro
Published: November 2023

Literature on packing problems in general is extensive and too broad to be covered here. One of the packing problems is packing for cylindrical material, that is packing for pipe. To pack the pipes, a mathematical model non linier mixed integer programming will be applied to explain packing problem mathematically. A combined genetic algorithm and tabu list is suggested to solve the mathematical problem to obtain satisfactory solution in terms of packing configuration and computational time. The algorithm gives a good result in terms of space utilization and computational time.

Abstract in Bahasa Indonesia :

Literatur mengenai permasalahan pengepakan (packing problem) secara umum telah dipelajari secara intensif dan sangat luas pengembangannya. Salah satu masalah pengepakan yang ada adalah masalah pengepakan silinder. Pada tulisan ini diteliti mengenai masalah yang merupakan bagian dari pengepakan silinder yaitu pengepakan pipa. Dalam pengepakan pipa digunakan model matematis non linier mixed integer programming untuk menerangkan permasalahan pengepakan secara matematis dan menyarankan menggunakan metode heuristik algoritma genetika (genetic algorithm) dipadukan dengan penggunaan daftar iterasi tabu untuk menyelesaikan model matematis yang dihadapi sehingga solusi yang dihasilkan dapat memuaskan ditinjau dari sisi konfigurasi pengepakan dan juga efisien ditinjau dari waktu komputasi. Algoritma yang diusulkan pada tulisan ini mampu memberikan konfigurasi pengepakan pipa yang memuaskan bila ditinjau dari pemanfaatan ruangan dan waktu komputasi yang cepat.

Kata kunci: pengepakan pipa, model matematis, Algotirma Genetika.
PERBANDINGAN METODE 2K-P FRACTIONAL FACTORIAL DENGAN METODE TAGUCHI PADA PROSES PEMBUATAN FIBER GLASS
Authors: Rahardjo Jani , Rahardja Suryanata
Published: November 2023

Fiber glass products are widely used in the industry. High quality fiberglass product requires a composition and to obtain the optimal composition, an experiment needs to be done. In this project, experimental designs in 2k-p fractional factorial design and Taguchi method were carried out to obtain the optimal composition.

According to the impact test results based on the model by the JIS (Japanese Industrial Standard) for fiber glass, it was found that the 2k-p fractional factorial design method and Taguchi methods are the same.

Abstract in Bahasa Indonesia :

Produk fiber glass banyak digunakan di dunia industri saat ini. Produk fiber glass berkualitas tinggi dibutuhkan suatu komposisi, dimana untuk komposisi yang tepat diperlukan eksperimen. Desain eksperimen 2k-p fractional factorial design dengan metode Taguchi telah digunakan untuk mendapatkan komposisi yang optimal.

Hasil pengujian kekuatan impak dengan bentuk dan pengujian sesuai JIS (Japanese Industrial Standard) pada fiber glass didapatkan bahwa metode 2k-p fractional factorial design dengan metode Taguchi tidak berbeda.

Kata kunci : 2k-p fractional factorial design, Taguchi, JIS
COMPARISON BETWEEN MIXED INTEGER PROGRAMMING WITH HEURISTIC METHOD FOR JOB SHOP SCHEDULING WITH SEPARABLE SEQUENCE-DEPENDENT SETUPS
Authors: Widyadana I Gede Agus
Published: November 2023

The decisions to choose appropriate tools for solving industrial problems are not just tools that achieve optimal solution only but it should consider computation time too. One of industrial problems that still difficult to achieve both criteria is scheduling problem. This paper discuss comparison between mixed integer programming which result optimal solution and heuristic method to solve job shop scheduling problem with separable sequence-dependent setup. The problems are generated and the result shows that the heuristic methods still cannot satisfy optimal solution.
PENGUKURAN DAN ANALISA KINERJA DENGAN METODE BALANCED SCORECARD DI PT. "X"
Authors: L. Singgih Moses , Octavia Renny , Damayanti Kristiana Asih
Published: November 2023

This research is done to measure and analyse of "X" Corporatio's performance used Balanced Scorecard method. This research is done because the measurement system that used for this time is just measure the performance of financial perpective

Abstract in Bahasa Indonesia :

Penelitian ini dilakukan untuk mengukur dan menganalisa kinerja di PT."X" dengan menggunakan metode Balanced Scorecard. Penelitian ini dilakukan karena sistem pengukuran yang dipakai selama ini hanya mengukur kinerja dari financial perspective.

Kata kunci: Pengukuran dan analisa kinerja, Balanced Scorecard.
SISTEM INFORMASI MANUFAKTUR DALAM KERANGKA KERJA SISTEM INFORMASI MANAJEMEN
Authors: Yahya Bernardo Nugroho
Published: November 2023

The value of an information is more valuable than the value of an investment. To make in information needs a system that can produce an accurate & priceless information. Management Information System needs to be defined more details to get a specific information, especially for production activity (manufacturing). Manufacture Information System can support the whole manufacture activity to make a good product in means of time, cost and also quality.

Abstract in Bahasa Indonesia :

Nilai sebuah informasi lebih berharga daripada nilai investasi. Oleh karena itu, dalam membuat sebuah informasi diperlukan sebuah sistem yang dapat membuat sebuah informasi yang tepat dan akurat. Sistem Informasi Manajemen perlu didefinisikan lebih detail untuk mendapatkan informasi yang lebih spesifik, khususnya untuk kegiatan produksi (manufaktur). Sistem Informasi Manufaktur dapat mendukung kegiatan manufaktur secara keseluruhan untuk menghasilkan produk yang baik dari segi waktu, biaya dan kualitas.

Kata kunci: Sistem Informasi Manajemen, Sistem Informasi Manufaktur.
DESIGN OF INFORMATION SYSTEM FOR QUALITY MANAGEMENT
Authors: Halim Yulius
Published: November 2023

A quality management recently has been the concepts that using a great mass of information flow. The unique function of information in quality management has become the driver of this study. There is a need of building the model for quality management information system before designing the information system. This paper will show two points that important for the information system. The points, database model and expert system, will be explained as the part of the information system for quality management.
DYNAMIC ABC STORAGE POLICY IN ERRATIC DEMAND ENVIRONMENTS
Authors: Pierre Benjamin , Vannieuwenhuyse Bart , Dominanta Denis , Dessel Hendrik Van
Published: November 2023

The paper describes a dynamic variant of the traditional ABC storage policy. The variant is to be used in manual order picking warehouses where SKUs experience a rather unstable demand. Its objective is to reduce the order picking time. It mainly consists in shifting items between the storage areas A, B and C according to the way their daily number of order lines changes. A few case studies based on computer simulations have shown that this variant can yield interesting time savings if its parameters are chosen with care. One of those case studies is presented in this paper. Because of the pioneering nature of this variant, some ideas for further research are also sketched.
PENINGKATAN EFEKTIFITAS DAN EFISIENSI BIAYA KUALITAS MELALUI PENEDEKATAN SIMULASI (Studi Kasus di CV. SINAR BAJA ELEKTRIC)
Authors: Widyadana I Gede Agus , Elsie Elsie
Published: November 2023

The paper discusses about how to increase product quality and still concern with quality cost. We add factor of time to count quality cost and the effect to quality product. Time has important function in this research, so simulation is used to analyze quality control system. The simulation on CV. Sinar Baja Elektrik shows that the propose method can decrease product reject about 8% and quality cost until 16,89% from total sales.

Abstract in Bahasa Indonesia :

Makalah ini membahas mengenai upaya untuk meningkatkan kualitas produk dengan memperhatikan biaya kualitas. Penelitian ini memasukan tambahan faktor waktu dalam memperhitungkan biaya kualitas serta dampaknya pada kualitas produk. Oleh karena faktor waktu memegang peranan yang penting, maka analisa sistem pengendalian kualitas pada penelitian ini menggunakan metode simulasi. Hasil simulasi di CV. Sinar Baja Elektrik menunjukan metode yang diusulkan dapat menurunkan hasil rata-rata tingkat kelolosan produk cacat untuk tiap tipe speaker hingga berkisar 8%, dan total biaya kualitas secara keseluruhan dapat diturunkan hingga sebesar 16.89% dari total penjualan.

Kata kunci: biaya kualitas, efisiensi, efektivitas, simulasi.
SOLVING THE DEGREE CONSTRAINED MINIMUM SPANNING TREE PROBLEM USING TABU AND MODIFIED PENALTY SEARCH METHODS
Authors: Wamiliana Wamiliana
Published: November 2023

In this paper we consider the Degree Constrained Minimum Spanning Tree Problem. This problem is concerned with finding, in a given edge weighted graph G (all weights are non-negative), the minimum weight spanning tree T satisfying specified degree restrictions on the vertices. This problem arises naturally in communication networks where the degree of a vertex represents the number of line interfaces available at a center. Because of its NP-completeness, a number of heuristics have been proposed. In this paper we propose two new search methods: one based on the method of Tabu search and the other based on a penalty function approach. For comparative analysis, we test our methods on some benchmark problems. The computational results support our methods.
PENENTUAN KOMPOSISI BAHAN BAKU OPTIMAL PRODUK KECAP X DENGAN METODE TAGUCHI
Authors: Julianingsih Julianingsih , Aysia Debora Anne Yang , Soegianto Donny
Published: November 2023

The research aimed at getting ingredient composition of soy sauces that preferred by consumers, by means of Taguchi method. The first organoleptik test was carried out to find out consumers' responses to tastes, colors, and thickness of X soy sauces relative to other soy sauces. The results were applied as a reference in pre-experiment. Experiment results indicated that soy sauce whose composition was 23332233 was the most preferable soy sauce by consumers. The proposed' soy sauce was subject to final organoleptik test to find out consumer preference and position of the proposed' soy sauces. The results indicated that 65.4% of respondents liked the proposed' soy sauces. Tastes and thickness of the proposed' soy sauces have been more preferable by consumers relative to other soy sauces.

Abstract in Bahasa Indonesia :

Penelitian ini bertujuan untuk mendapatkan komposisi bahan baku kecap yang disukai konsumen, dengan menggunakan metode Taguchi. Uji organoleptik pertama dilakukan untuk mengetahui respon konsumen terhadap rasa, warna dan kekentalan kecap X terhadap kecap pesaing. Hasilnya digunakan sebagai acuan pre eksperimen. Hasil eksperimen menunjukkan bahwa kecap dengan komposisi 23332233, paling disukai konsumen. Kecap usulan diuji organoleptik akhir untuk mengetahui kesukaan konsumen dan posisi kecap usulan terhadap kecap pesaing. Hasilnya, 65,4% responden menyukai kecap usulan. Untuk rasa dan kekentalan, kecap usulan lebih disukai daripada kecap pesaing.

Kata kunci: Taguchi, Rasa, Warna, Kekentalan, Organoleptik
Nosocomial SARS-CoV-2 Infections and Mortality During Unique COVID-19 Epidemic Waves
Authors: Dave Nishi , Sjöholm Daniel , Hedberg Pontus , Ternhag Anders , Granath Fredrik , Verberk Janneke D. M. , Johansson Anders F. , van der Werff Suzanne D. , Nauclér Pontus
Published: November 2023

Importance

Quantifying the burden of nosocomial SARS-CoV-2 infections and associated mortality is necessary to assess the need for infection prevention and control measures.

Objective

To investigate the occurrence of nosocomial SARS-CoV-2 infections and associated 30-day mortality among patients admitted to hospitals in Region Stockholm, Sweden.

Design, Setting, and Participants

A retrospective, matched cohort study divided the period from March 1, 2020, until September 15, 2022, into a prevaccination period, early vaccination and pre-Omicron (period 1), and late vaccination and Omicron (period 2). From among 303 898 patients 18 years or older living in Region Stockholm, 538 951 hospital admissions across all hospitals were included. Hospitalized admissions with nosocomial SARS-CoV-2 infections were matched to as many as 5 hospitalized admissions without nosocomial SARS-CoV-2 by age, sex, length of stay, admission time, and hospital unit.

Exposure

Nosocomial SARS-CoV-2 infection defined as the first positive polymerase chain reaction test result at least 8 days after hospital admission or within 2 days after discharge.

Main Outcomes and Measures

Primary outcome of 30-day mortality was analyzed using time-to-event analyses with a Cox proportional hazards regression model adjusted for age, sex, educational level, and comorbidities.

Results

Among 2193 patients with SARS-CoV-2 infections or reinfections (1107 women [50.5%]; median age, 80 [IQR, 71-87] years), 2203 nosocomial SARS-CoV-2 infections were identified. The incidence rate of nosocomial SARS-CoV-2 infections was 1.57 (95% CI, 1.51-1.64) per 1000 patient-days. In the matched cohort, 1487 hospital admissions with nosocomial SARS-CoV-2 infections were matched to 5044 hospital admissions without nosocomial SARS-CoV-2 infections. Thirty-day mortality was higher in the prevaccination period (adjusted hazard ratio [AHR], 2.97 [95% CI, 2.50-3.53]) compared with period 1 (AHR, 2.08 [95% CI, 1.50-2.88]) or period 2 (AHR, 1.22 [95% CI, 0.92-1.60]). Among patients with nosocomial SARS-CoV-2 infections, 30-day AHR comparing those with 2 or more doses of SARS-CoV-2 vaccination and those with less than 2 doses was 0.64 (95% CI, 0.46-0.88).

Conclusions and Relevance

In this matched cohort study, nosocomial SARS-CoV-2 infections were associated with higher 30-day mortality during the early phases of the pandemic and lower mortality during the Omicron variant wave and after the introduction of vaccinations. Mitigation of excess mortality risk from nosocomial transmission should be a strong focus when population immunity is low through implementation of adequate infection prevention and control measures.
Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation
Authors: Farhadian Shelli F. , Reisert Hailey D. , McAlpine Lindsay , Chiarella Jennifer , Kosana Priya , Yoon Jennifer , Spudich Serena
Published: November 2023

This case-control study assesses cerebrospinal fluid markers of neuroinflammation and blood-brain barrier disruption in individuals with post–COVID-19 condition who reported neuropsychiatric symptoms.
Perceived Interpersonal Racism and Incident Stroke Among US Black Women
Authors: Sheehy Shanshan , Aparicio Hugo J. , Palmer Julie R. , Cozier Yvette , Lioutas Vasileios-Arsenios , Shulman Julie G. , Rosenberg Lynn
Published: November 2023

Importance

Black individuals in the US experience stroke and stroke-related mortality at younger ages and more frequently than other racial groups. Studies examining the prospective association of interpersonal racism with stroke are lacking.

Objective

To examine the association of perceived interpersonal racism with incident stroke among US Black women.

Design, Setting, and Participants

The Black Women’s Health Study, a prospective cohort study of 59 000 Black women from across the US, assessed the longitudinal association between perceived interpersonal racism and stroke incidence. Stroke-free participants were followed up from 1997 until onset of stroke, death, loss to follow-up, or the end of the study period (December 31, 2019). Cox models were used to estimate hazard ratios (HRs) and 95% CIs, adjusting for major confounders, including education, neighborhood socioeconomic environment, and cardiometabolic factors. Data analysis was performed from March 2021 until December 2022.

Exposure

On a questionnaire completed in 1997, participants reported experiences of racism in everyday life and when dealing with situations that involved employment, housing, and interactions with police.

Main Outcomes and Measures

Strokes were identified through self-report on biennial questionnaires, medical records adjudication, and linkage with the National Death Index.

Results

In 1997, 48 375 Black women (mean [SD] age, 41 [10] years) provided information on perceived interpersonal racism and were free of cardiovascular disease and cancer. During the 22 years of follow-up, 1664 incident stroke cases were identified; among them, 550 were definite cases confirmed by neurologist review and/or National Death Index linkage. Multivariable HRs for reported experiences of racism in all 3 domains of employment, housing, and interactions with police vs no such experiences were 1.38 (95% CI, 1.14-1.67), a 38% increase, for all incident cases and 1.37 (95% CI, 1.00-1.88) for definite cases. For comparisons of women in the highest quartile of everyday interpersonal racism score vs women in the lowest quartile, multivariable HRs were 1.14 (95% CI, 0.97-1.35) for analyses that included all incident stroke and 1.09 (95% CI, 0.83-1.45) for analyses that included definite cases only.

Conclusions and Relevance

In this study, Black women who reported experiences of interpersonal racism in situations involving employment, housing, and interactions with police appeared to have an increased risk of stroke, even after accounting for demographic and vascular risk factors, suggesting that the high burden of racism experienced by Black US women may contribute to racial disparities in stroke incidence.
Study will use OTP to look at methadone reform
Authors: Knopf Alison
Published: November 2023

A new study funded by the National Institute on Drug Abuse (NIDA) and headed by researchers interested in changing the way methadone for opioid use disorder is utilized will use Community Medical Services treatment staff and patients as research subjects. Community Medical Services operates more than 60 opioid treatment programs in 11 states, and is the first OTP, or methadone clinic, to be open around the clock in some areas, with head Nicholas Stavros incorporating novel ways to reach out to patients. The MPACT (Methadone Patient Access to Collaborative Treatment) study will develop and test a medical intervention using a $1 million NIDA grant. Researchers at the University of Arizona Health Sciences, under the direction of Beth Meyerson, Ph.D., will test a “patient‐empowered, trauma‐informed” treatment using methadone in Arizona. Meyerson is a professor, and director of the Harm Reduction Research Lab in the University of Arizona College of Medicine at Tucson. The study will take two years. “Improving methadone treatment is critical because one person dies from an opioid overdose every five minutes in this country,” said Meyerson, who is also director of policy for the University of Arizona Health Sciences Comprehensive Pain and Addiction Center. “Access to methadone has been found to reduce opioid overdoses by 80%, but it is currently being delivered in ways that can create suboptimal patient outcomes, where only 30% of patients complete treatment and over 30% experience significant treatment interruptions.” The protocol will be used to focus on how to make treatment more acceptable to patients and includes a staff‐focused intervention to reduce trauma related to actually working in the OTP. “Vicarious trauma has been found to impact both patient care and staff recognition of the need to adopt treatment and practice innovations,” Meyerson said, adding, “This study is the crucial first step in assessing MPACT's feasibility, acceptability and preliminary effects on patient and staff outcomes. Once our established milestones are reached from the pilot program, the second phase of funding will enable us to expand the study of MPACT among 30 clinics with 600 patients and 450 staff members across the U.S.” Kristen Rundell, M.D., professor and chair of the Department of Family and Community Medicine at the University of Arizona, where Meyerson's harm reduction lab is based, said the study “is a prime example of our department's emphasis of social justice through medicine.”
Co‐occurring BD and AUD associated with increased craving
Authors: Knopf Alison
Published: November 2023

Researchers studied reward circuitry dysfunction, which may be a mechanism of co‐occurring bipolar disorder (BD) and alcohol use disorder (AUD), using functional magnetic resonance imaging (fMRI). The objective was to find out how alcohol cue processing differs in people with co‐occurring BD and AUD compared with people who have either one of the disorders. They used a visual alcohol cue reactivity paradigm following one week or more of abstinence from alcohol and other drugs. They rated past‐week mood symptoms for depression and mania, as well as obsessive‐compulsive drinking and impulsiveness. Function MRI was analyzed focusing on the ventral striatum, dorsal striatum, and ventromedial prefrontal cortex. The researchers analyzed associations between cue reactivity and select behavioral correlates, namely, alcohol craving, impulsivity, maximum number of alcohol drinks on a single occasion and days since last alcohol drink). Of the 112 participants, 28 (25.0%) had BD and AUD, 26 (23.2%) had AUD alone, 31 (27.7%) had BD alone, and 27 (24.1%) were healthy controls. The mean age was 38.7 years, 50 (45.5%) were female, 33 (30%) were smokers, and 37 (34.9%) reported recent alcohol consumption. Individuals with BD and AUD exhibited reduced activation compared with all other groups. Other groups did not significantly differ from one another. The hypo‐activations were associated with increased impulsivity and obsessive‐compulsive alcohol craving exclusively among individuals with BD and AUD. The researchers concluded that the potential interaction between BD and AUD blunted the response to rewards and decreased inhibitory control. They added that reduced right inferior frontal gyrus and insula alcohol cue reactivity is a novel biomarker of comorbid BD and AUD that may respond to pharmacological interventions targeting impulsivity‐related neural mechanisms for improved executive control. The study, “Alcohol Cue Processing in Co‐Occurring Bipolar Disorder and Alcohol Use Disorder, is by William H. Mellick, Ph.D., and colleagues, and was conducted at the Medical University of South Carolina, Addiction Sciences Division and published Nov. 1 in JAMA Psychiatry.
4D Printed Poly(l‐lactide)/(FeCl3–TA/MgO) Composite Scaffolds with Near‐Infrared Light‐Induced Shape‐Memory Effect and Antibacterial Properties
Authors: Guo Wenqiang , Zhou Beibei , Zou Yulong , Lu Xili
Published: November 2023

Near‐infrared (NIR) light‐responsive shape‐memory polymers have drawn increasing attention because NIR light is safe and easy to perform in biological applications. Herein, a novel NIR light‐responsive shape‐memory polymer composite is developed, which comprises poly(l‐lactide) (PLLA) matrix and surface‐modified magnesium oxide (MgO) nanoparticles by ferric chloride (FeCl3) and tannic acid (TA) (FeCl3–TA/MgO). This design can fully combine the printability and shape‐memory effect of PLLA, the excellent bioactivity, and the outstanding photothermal effect of MgO nanoparticles modified by FeCl3–TA. The PLLA/(FeCl3–TA/MgO) composite scaffolds with a homogeneously porous structure are further fabricated by 4D printing. The synergetic presence of components and fabrication process can endow the prepared composite scaffolds with enhanced mechanical properties and stable NIR light‐induced shape‐memory effect, as well as antibacterial and antioxidant properties. With 5 wt% FeCl3–TA/MgO particles, the scaffold not only has a compress modulus of 0.93 MPa, which is 4 times that of a pristine PLLA scaffold, but also achieves a shape fixation ratio of 95.7% and a shape recovery ratio of 80.9% under NIR light irradiation at 2 w cm−2. The PLLA/(FeCl3–TA/MgO) composites have great potential for application in the field of bone tissue engineering scaffolds.
Nano‐confined Supramolecular Assembly of Ultrathin Crystalline Polymer Membranes for High‐Performance Nanofiltration
Authors: Lu Gang , Lu Shuang , Sun Jiawei , Boey Min Wei , Shang Wentao , Wu Jun , An Alicia Kyoungjin
Published: November 2023

Polymer membranes with high permeability, high salt rejection, and mechanical integrity are desirable in water treatment and purification. However, it remains a daunting challenge to achieve ultrathin yet robust polymer membranes harvesting all the above features for nanofiltration. Here, a new approach of nano‐confined supramolecular assembly to fabricate ultrathin crystalline polymer membranes with a modulus of 1 GPa and a thickness of 6.5 nm is reported. The microdroplet carrying amphiphilic tetra‐oligomers can quickly spread at the air–‐water interface, where the hydrophilic motifs such as carbonyl and hydroxyl groups can reconfigurably anchor down to water molecules via abundant hydrogen bonding interactions, significantly promoting the alignment and orientation of hydrophobic alkyl chains within the nano‐confined space. The resultant nano‐films exhibit mechanical robustness as well as excellent ion sieving with improved NaCl rejection of 81.3% and unprecedented Na2SO4 rejection of 99.9% without compromising water permeation, outperforming the reported and commercial state‐of‐the‐art polymer membranes. This work enables the rapid production of over 100 cm2 ultrathin crystalline polymer membranes with great nanofiltration potential and highlights the critical role of supramolecular assembly in the chemical and structural configurations in a nano‐confined space.
Electroconductive and Immunomodulatory Natural Polymer‐Based Hydrogel Bandages Designed for Peripheral Nerve Regeneration
Authors: Wang Shuting , Lu Haotian , Kang Xinchang , Wang Zhenqing , Yan Shengtao , Zhang Xuehui , Shi Xuetao
Published: November 2023

Successful regeneration of the peripheral nerve relies on the collaborative efforts of neural cells and immune cells. Conductive hydrogels have yielded promising results in supporting axonal growth; however, their inability to regulate the immune response and their poor biological integration with tissues hinder the repair of injured peripheral nerves. Herein, an adhesive conductive immunomodulatory nerve hydrogel bandage is developed for nerve regeneration. The nerve bandage hydrogel is prepared from the bioactive material extracellular matrix (ECM), oxidized polysaccharides, and poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS) by self‐assembly and dynamic Schiff base cross‐linking. The drug indole‐3‐propionic acid (IPA) is loaded into nerve bandages and contributes to the rapid chemotaxis of neutrophils in the dorsal root ganglia and modulation of the immune system. In addition, the conductive hydrogel bandage exhibits close conformal contact with the injured nerve, forming a stable and tightly coupled electrical bridge with the electroresponsive neural tissue. In summary, the nerve bandage effectively promote nerve regeneration and enable both anatomical and functional recovery of neural tissue while preventing muscle atrophy. This work provides a new strategy for peripheral nerve regeneration and may have critical clinical applications in the future.
Real‐Time Spatiotemporal Measurement of Extracellular Signaling Molecules Using an Aptamer Switch‐Conjugated Hydrogel Matrix
Authors: Park Chan Ho , Thompson Ian A. P. , Newman Sharon S. , Hein Linus A. , Lian Xizhen , Fu Kaiyu X. , Pan Jing , Eisenstein Michael , Soh H. Tom
Published: November 2023

Cells rely on secreted signaling molecules to coordinate essential biological functions including development, metabolism, and immunity. Unfortunately, such signaling processes remain difficult to measure with sufficient chemical specificity and temporal resolution. To address this need, an aptamer‐conjugated hydrogel matrix that enables continuous fluorescent measurement of specific secreted analytes – in two dimensions, in real‐time is developed. As a proof of concept, real‐time imaging of inter‐cellular cyclic adenosine 3',5'‐monophosphate (cAMP) signals in Dictyostelium discoideum amoeba cells is performed. A set of aptamer switches that generate a rapid and reversible change in fluorescence in response to cAMP signals is engineered. By combining multiple switches with different dynamic ranges, measure cAMP concentrations spanning three orders of magnitude in a single experiment can be measured. These sensors are embedded within a biocompatible hydrogel on which cells are cultured and their cAMP secretions can be imaged using fluorescent microscopy. Using this aptamer‐hydrogel material system, the first direct measurements of oscillatory cAMP signaling that correlate closely with previous indirect measurements are achieved. Using different aptamer switches, this approach can be generalized for measuring other secreted molecules to directly visualize diverse extracellular signaling processes and the biological effects that they trigger in recipient cells.
Designing Chemically Replaced Interfacial Layer via Unveiling the Influence of Zn Crystal Facets for Practical Zn‐Metal Anodes
Authors: Park Jung Been , Choi Changhoon , Jung Sang Won , Min Byeong Chan , Park Jong Hyun , Kim Dong‐Wan
Published: November 2023

Zn metal anodes (ZMAs) undergo irregular deposition and unfavorable side reactions, which hinders the practical application of aqueous rechargeable Zn metal batteries (ARZMBs). Chemical replacement reaction (CRR) strategies can achieve stable ZMAs, but the effect of the crystal facets of metallic Zn as reductants remains poorly understood. In this study, based on the observation that preferentially exposed Zn crystal facets affect the surface characteristics of chemically replaced layers in Sn‐based CRR, a multifunctional Sn‐based interfacial layer (ZnTCF@Sn) is designed on the Zn with textured crystal facets using a novel two‐step CRR process. ZnTCF@Sn simultaneously provides abundant zincophilic sites and high surface energy and homogenizes the distribution of current/Zn2+ flux, resulting in fast electrochemical kinetics and dendrite‐free deposition. Furthermore, the uniform Sn coverage on the ZnTCF@Sn surface inhibits side reactions and enhances reversibility during Zn deposition/dissolution. Thus, the ZnTCF@Sn achieves exceptional cyclability over 1200 h even under harsh operating conditions with a cumulative capacity of 24 Ah cm−2. This study contributes to the development of practical ARZMBs by providing new insights into the effect of the Zn crystal facets on the surface modification of ZMAs through various CRRs.
Modeling the Osteogenic Potential of Decellularized Human Bone Particles by Tuning their Size Distribution Through a Sonic Microfragmentation Approach
Authors: Bucciarelli Alessio , Pedranz Alessandro , Gambari Laura , Petretta Mauro , Vivarelli Leonardo , Dallari Dante , Grigolo Brunella , Maniglio Devid , Grassi Francesco
Published: November 2023

Human decellularized bone fragments are commonly used in clinics to perform allograft surgeries. To reduce the immunological response in the recipient and ensure their safety, these fragments underwent decellularization, a procedure that greatly reduces their osteogenicity (the ability to induce differentiation into osteoblast). In this work, by the introduction of an ultrasonication step to fragment the human bone, the size distribution of the resulting demineralize bone particles can be controlled, tuning their osteogenic potential. The sonication protocol is optimized by a response surface method, using 12 different sonication protocols, allowing to model the relationship between the sonication parameters and the outcoming particles properties in terms of dimensions, physical/chemical properties, and biological activity. The size distribution is extrapolated by a deep learning image segmentation while the structure is characterized by infrared and thermal analysis. The particles are combined with methacrylated silk gel to test in vitro their biological response on adipose‐derived stromal cells. The ultrasonication fragmented the bone particles, revealing their internal organic matrix as proved by secondary electron microscopy and confocal microscopy. An inverse linear correlation is found between the particles’ sizes and their osteogenic activity, thus proving the efficacy of the proposed ultrasonication treatment in tuning the biological response.
Packaged Elastomeric Optical Fiber Sensors for Healthcare Monitoring and Human‐Machine Interaction
Authors: Zhang Zhenhua , Zhang Lei
Published: November 2023

Elastomeric polymer optical fiber (EPOF) enabled flexible optical sensors have been attracting intensive research interest due to their excellent stretchability, sensing performance, and anti‐electromagnetic interference. However, a soft EPOF without effective protection tends to be damaged, which may undermine its long‐term stability, and thus, limit its practical applications. In this work, a strategy for packaging a section of EPOF is proposed, a light‐emitting diode (LED), and a photodiode (PD) into a stretchable and flexible silicone patch for both healthcare and human‐machine interaction applications. The silicone package not only protects the EPOF from environmental disturbance, providing a compact sensing approach for conformal attachment on flexible or curved surfaces but also offers an effective manner to adjust the sensitivity and working range of the EPOF sensors. Typically, an EPOF sensor is sensitive to pressure, strain, or bending. As a proof‐of‐concept demonstration, a laryngoscope equipped with a packaged EPOF sensor that can bear a pressure of 60 MPa is developed. It can effectively avoid teeth damage by real‐time monitoring the contact force during the operation. Furthermore, a data glove with five packaged EPOF sensors for hand gesture recognition and remote control of a micro‐vehicle is fabricated.
Cobalt Polyoxometalates Anchored on Nife‐LDH Nanoplates as Highly Active and Stable Bifunctional Catalysts for Overall Water Splitting
Authors: Wang Wei , Cai Mingxin , Wang Tian , Hou Shuang , Huang Xinjie , Wang Ziru , Lu Zhiyi , He Peilei
Published: November 2023

Designing efficient and bifunctional electrocatalysts for water splitting conforms to the concept of energy conservation and emission reduction but remains challenging now. Herein, the fabrication of a heterostructure by anchoring cobalt‐polyoxometalates (Co‐POM) on NiFe layered double hydroxide (NiFe‐LDH) nanoplates in situ on nickel foam (NF) is first reported (Co‐POM@LDH/NF). The surface area, electron transfer ability, and stability of the heterostructure are increased due to the synergistic effect between Co‐POM and NiFe‐LDH. Particularly, Co‐POM@LDH/NF can deliver a current density of 100 mA cm−2 with an overpotential of only 220 mV for hydrogen evolution reaction (HER) and 226 mV for oxygen evolution reaction (OER) in 1.0 m KOH electrolytes. Impressively, the outstanding stability of Co‐POMs in heterostructures is verified by the experimental observations after electrolysis, indicating the successful construction of stable POMs‐based heterogeneous electrocatalysts. More attractively, the electrolyzer composed by Co‐POM@LDH/NF as anode and cathode shows a much lower operating voltage of 1.51 V at the current density of 10 mA cm−2 for overall water splitting. This study provides a feasible and extensible idea for the design of the POM‐based heterostructures.
Single Atom Silver‐Phosphors in Titanosilicate Matrix for Enhanced LED Applications
Authors: Romolini Giacomo , Sun Li , Fron Eduard , Acapito Francesco d’ , Grandjean Didier , Roeffaers Maarten B.J. , Martìn Cristina , Hofkens Johan
Published: November 2023

Small metal oligomers have gained significant attention due to their exceptional optoelectronic properties and versatile applications, ranging from sensors to imaging and catalysis. However, the need for matrices (silica, zeolites, or metal‐organic frameworks) to prevent aggregation into larger metallic particles reduces their potential applicability in light‐emitting devices (LEDs) due to their poor electrical properties. To address this issue, a novel semiconductor stabilizer, titanosilicate, is proposed as an innovative solution for Ag‐based luminescent materials. These results show that titanosilicate, characterized by high thermochemical stability and well‐defined semiconducting properties, is an ideal scaffold for Ag‐luminescent species. Optical spectroscopic techniques reveal that Ag‐titanosilicates feature an orange fluorescence with a photoluminescence quantum yield reaching 20%. In contrast, a combination of X‐ray diffraction, TEM, and XEOL‐X‐ray absorption spectroscopic techniques show that, unlike zeolites, the luminescent species consist of single Ag atoms. The electroluminescent properties of the proposed Ag‐titanosilicate are further investigated within a conventional LED architecture by using the new material as an emissive layer. The developed proof‐of‐concept LED exhibits a significant improvement of the ZEOLEDs, where a smaller low turn‐on voltage of 2 V (enabling energy‐efficient operation) and high color rendering index of 80 introduces exciting prospects for developing advanced Ag‐LED phosphors.
Temperature Correction of Printed Na+, K+, and pH Sensors with PEDOT:PSS‐Based Thermistors toward Wearable Sweat Sensing
Authors: Shiwaku Rei , Matsui Hiroyuki , Nagamine Kuniaki , Tokito Shizuo
Published: November 2023

Temperature correction for sensors is a critical aspect of ensuring accurate measurements in wearable devices, because skin and sweat temperatures vary between 20 and 40 °C depending on individual and time. Here, this study reports on the temperature dependence and correction techniques of printed Na+, K+, and pH sensors toward wearable applications. The ion sensor array is fabricated using a cost‐effective printing method. To enable temperature correction, a printed thermistor of crosslinked poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is monolithically integrated with the ion sensor array on a flexible plastic substrate. Temperature dependence of the potential response of the printed ion sensors exhibits a linear behavior with a slope of 1–2 mV °C−1 in the physiological skin temperature range of 20–40 °C. Applying temperature correction to the ion sensors, the maximum relative errors are reduced from 60% to 7.8% for the Na+ sensors and from 76% to 14.6% for the K+ sensors, while the maximum absolute error is reduced from 0.88 to 0.19 for the pH sensors, indicating the critical importance of temperature correction as a technology for wearable printed ion sensors.
Copper Coordination‐Based Nanomedicine for Tumor Theranostics
Authors: Han Yuanfeng , Xie Nuli , Zhou Wenhu
Published: November 2023

Copper (Cu) is an essential micronutrient for a variety of basic biological processes, including cell metabolism, proliferation, and angiogenesis. Recently, the concept of cuproptosis has been found to be related to the direct binding of Cu to the lipoylated components of the tricarboxylic acid cycle. This further demonstrates the important role of Cu and promotes Cu‐involved biomedical research. Currently, Cu‐related nanomedicines is mainly based on Cu coordination chemistry, and targeting Cu become a research hotspot for cancer therapy. On one hand, chelating excess Cu in vivo to inhibit angiogenesis, on the other hand, supplementing Cu and Cu‐coordinated complexes to produce oxidative stress and proteasome inhibition. In this review, the principles of Cu‐coordination chemistry and the biochemical functions of Cu ions are described, and a comprehensive review of Cu‐coordinated nanomedicine, including Cu chelation and Cu supplementation, delivery of Cu‐coordinated nanodrugs, and Cu‐coordinated nanocarriers is provided. Finally, the limitations are analyzed to point out the directions for improvement in future research. It is believed that the development of Cu‐coordinated nanomedicine will enter the fast track and show great promise in cancer theranostics.