bluuebunny/crossref_metadata_2025 huggingface dataset:
Life Management Strategies as Mediators Between Information Processing Style and Subjective Well-Being
Authors: Shirzadifard Maysam , Shahghasemi Ehsan , Hejazi Elaheh , Aminipour Shima
Published: October 2020

This study investigates the mediating role of life management strategies to see how information processing styles indirectly influence subjective well-being. Participants were 440 university students (female = 202, male = 238) ranging in age from 18 to 50 years from all levels and all majors from universities in Quchan, Iran. In a nonexperimental design and by using path analysis, we found that selection, optimization, and compensation fully mediated the relationship between information processing styles and subjective well-being. Our proposed model fitted well to the data and could account for a significant proportion of variance in satisfaction with life, positive affects, and negative affects’ scores (42%, 51%, and 35%, respectively). These results provide empirical evidence that rational information processing style is a defining factor for planning, and its impact on subjective indicators of well-being operates indirectly and through life management strategies. This model, with a more active approach, has implications for both theory and practice in psychotherapy.
Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes
Authors: Scholze Hanna , Stephenson Regan E. , Reynolds Raymond , Shah Shivem , Puri Rishi , Butler Scott D. , Trujillo-Alonso Vicenta , Teater Matthew R. , van Besien Herman , Gibbs-Curtis Destini , Ueno Hideki , Parvin Salma , Letai Anthony , Mathew Susan , Singh Ankur , Cesarman Ethel , Melnick Ari , Giulino-Roth Lisa
Published: October 2020

Molecular alterations in the histone methyltransferase EZH2 and the antiapoptotic protein Bcl-2 frequently co-occur in diffuse large B-cell lymphoma (DLBCL). Because DLBCL tumors with these characteristics are likely dependent on both oncogenes, dual targeting of EZH2 and Bcl-2 is a rational therapeutic approach. We hypothesized that EZH2 and Bcl-2 inhibition would be synergistic in DLBCL. To test this, we evaluated the EZH2 inhibitor tazemetostat and the Bcl-2 inhibitor venetoclax in DLBCL cells, 3-dimensional lymphoma organoids, and patient-derived xenografts (PDXs). We found that tazemetostat and venetoclax are synergistic in DLBCL cells and 3-dimensional lymphoma organoids that harbor an EZH2 mutation and an IGH/BCL2 translocation but not in wild-type cells. Tazemetostat treatment results in upregulation of proapoptotic Bcl-2 family members and priming of mitochondria to BH3-mediated apoptosis, which may sensitize cells to venetoclax. The combination of tazemetostat and venetoclax was also synergistic in vivo. In DLBCL PDXs, short-course combination therapy resulted in complete remissions that were durable over time and associated with superior overall survival compared with either drug alone.
Mixture toxicity analysis in zebrafish embryo: a time and concentration resolved study on mixture effect predictivity
Authors: Jakobs Gianina , Krüger Janet , Schüttler Andreas , Altenburger Rolf , Busch Wibke
Published: October 2020

Background

Humans and wildlife are continuously exposed to chemical mixtures. These mixtures vary in composition but typically contain hundreds of micropollutants at low concentrations. As it is not feasible to measure the toxicity of all possibly occurring mixtures, there is a need to predict mixture toxicity. Two models, Concentration Addition (CA) and Independent Action (IA), have been applied to estimate mixture toxicity. Here, we compared measured with predicted toxicity of nine mixtures designed from 15 environmentally relevant substances in zebrafish embryos to investigate the usability of these models for predicting phenotypic effects in a whole organism short term acute assay.

Results

In total, we compared 177 toxicity values derived from 31 exposure scenarios with their predicted counterparts. Our results show that mixture toxicity was either correctly estimated (86%) by the prediction window, the concentration-effect space that is spanned between both models, or was underestimated with both models (14%). The CA model correctly predicted the measured mixture toxicity in 100% of cases when a prediction deviation factor of 2.5 was allowed. However, prediction accuracy of mixture toxicity prediction was dependent on exposure duration and mixture potency. The CA model showed highest prediction quality for long-term exposure with highly potent mixtures, respectively, whereas IA proved to be more accurate for short-term exposure with less potent mixtures. Obtained mixture concentration–response curves were steep and indicated the occurrence of remarkable combined effects as mixture constituents were applied at concentrations below their respective individual effect threshold in 90% of all investigated cases.

Conclusions

Experimental factors, such as exposure duration or mixture potency, influence the prediction accuracy of both inspected models. The CA model showed highest prediction accuracy even for a set of diverse mixtures and various exposure conditions. However, the prediction window served as the most robust predicator to estimate mixture toxicity. Overall, our results demonstrate the importance of considering mixture toxicity in risk assessment schemes and give guidance for future experiment design regarding mixture toxicity investigations.
Literature mining for context-specific molecular relations using multimodal representations (COMMODAR)
Authors: Lee Jaehyun , Lee Doheon , Lee Kwang Hyung
Published: October 2020

Biological contextual information helps understand various phenomena occurring in the biological systems consisting of complex molecular relations. The construction of context-specific relational resources vastly relies on laborious manual extraction from unstructured literature. In this paper, we propose COMMODAR, a machine learning-based literature mining framework for context-specific molecular relations using multimodal representations. The main idea of COMMODAR is the feature augmentation by the cooperation of multimodal representations for relation extraction. We leveraged biomedical domain knowledge as well as canonical linguistic information for more comprehensive representations of textual sources. The models based on multiple modalities outperformed those solely based on the linguistic modality. We applied COMMODAR to the 14 million PubMed abstracts and extracted 9214 context-specific molecular relations. All corpora, extracted data, evaluation results, and the implementation code are downloadable athttps://github.com/jae-hyun-lee/commodar.

Ccs concepts

• Computing methodologies~Information extraction • Computing methodologies~Neural networks • Applied computing~Biological networks.
Effects of whole body vibration with exercise therapy versus exercise therapy alone on flexibility, vertical jump height, agility and pain in athletes with patellofemoral pain: a randomized clinical trial
Authors: Rasti Ebrahim , Rojhani-Shirazi Zahra , Ebrahimi Naghmeh , Sobhan Mohammad Reza
Published: October 2020

Background

Patellofemoral pain (PFP) is the most prevalent orthopedic problem in active young adults. Due to its multifactorial etiology, a variety of therapeutic measures have been adopted to treat PFP, including exercise therapy, electrotherapy, and manual therapy. It has also been suggested that whole body vibration (WBV) can improve neuromuscular function in persons with knee problems. The aim of the present study was to evaluate the effects of adding WBV to routine exercise programs on flexibility, vertical jump height, agility and pain in athletes with PFP.

Methods

Twenty-four male athletes with PFP were randomized into two groups of WBV + exercise (n = 12) or exercise only (n = 12). Participants received their interventions during 4 consecutive weeks (12 sessions). Pain intensity, flexibility and agility were assessed respectively as score on a numerical rating scale, the sit-and-reach test, and a modified T-test, and vertical jump height was measured to the nearest centimeter. The tests were done before and after the interventions, and the results were compared between the two groups. Independent t-tests and paired t-tests were used for between- and within-group comparisons, respectively.

Results

After the interventions, all variables for vertical jump height, flexibility, agility and pain intensity improved significantly in both groups (p < 0.05). The flexibility test showed significantly greater improvement in the WBV + exercise group (p<0.001), whereas for vertical jump height, agility and pain intensity, there were no statistically significant differences between groups (p>0.05).

Conclusions

The present findings showed that exercise therapy with and without WBV can significantly decrease pain and increase agility, vertical jump height and flexibility in athletes with PFP. Adding WBV to routine exercise therapy, however, can augment the effects of the latter on flexibility.

Trial registration

IRCT, IRCT20090831002391N39. Registered 7 February 2018,https://en.irct.ir/search/result?query=IRCT20090831002391N39.
Reaching out to stakeholders: The use of knowledge terminology on the websites of Australian public hospitals
Authors: Miklosik Andrej , Evans Nina
Published: October 2020

Background

The objective of the study described in this article was to examine whether, and to what extent, Australian public hospitals use knowledge terminology, i.e. a body of knowledge-related terms, on their websites. The paper also discusses the difference in the level of such communication between large and small hospitals, the factors affecting the use of the knowledge-related terms in the communication and the similarities/differences between the use of knowledge terms in Australian public hospitals and large/small companies in Australia.

Methods

151 Australian public hospitals were included in the research sample: 51 large and 100 small hospitals. Using the method of content analysis, websites mentioning knowledge creation, knowledge sharing, knowledge implementation, and knowledge retention were identified, along with the number of these mentions. Descriptive statistics and chi square test of independence were used to provide answers to four research questions.

Results

Of the 151 hospitals included in the sample, 30 had no website and 62 (50 small and 12 large) had a single page website. The study found that there are differences between Australian public hospitals regarding the level of their knowledge communication on their websites, both between small and large hospitals and between the individual hospitals within the large and small hospital groups.

Conclusions

A well-known saying goes “For the mouth speaks what the heart is full of”. Effective communication of knowledge-related terminologies to both internal and external stakeholders, i.e. the parties who access the websites, is therefore an indication of a knowledge focus in the public hospitals. Large hospitals are generally more active in communicating knowledge terms, although there are some exceptions. Some of the small hospitals can lead by example, but most of them do not include knowledge terminology in their communication on websites.
Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines
Authors: Briones Jamaica Roanne , Talungchit Pattarawalai , Thavorncharoensap Montarat , Chaikledkaew Usa
Published: October 2020

Background

The World Health Organization (WHO) recommends oxytocin as the drug of choice for postpartum hemorrhage (PPH) prevention. However, the WHO has also recently considered carbetocin for PPH prevention, but only if carbetocin were a cost-effective choice in the country. Consequently, we determined the cost-effectiveness and budgetary impact of carbetocin against oxytocin in the Philippines.

Methods

A cost-utility analysis using a decision tree was done to compare the costs and outcomes of carbetocin with oxytocin for PPH prophylaxis among women undergoing either vaginal delivery (VD) or cesarean section (CS) in a six-week time horizon using a societal perspective. One-way and probabilistic sensitivity analyses were applied to investigate parameter uncertainties. Additionally, budget impact analysis was conducted using a governmental perspective. Results were presented as incremental cost-effectiveness ratio (ICER) using a 2895 United States dollar (USD) per quality adjusted life year (QALY) gained as the ceiling threshold in the Philippines.

Results

Carbetocin was not cost-effective given the listed price of carbetocin at 18 USD. Given a societal perspective, the ICER values of 13,187 USD and over 40,000 USD per QALY gained were derived for CS and VD, respectively. Moreover, the ICER values were sensitive to the risk ratio of carbetocin versus oxytocin and carbetocin price. On budget impact, the five-year total budget impact of a drug mix of carbetocin and oxytocin was 25.54 million USD (4.23 million USD for CS and 21.31 million USD for VD) compared with ‘only oxytocin’ scenario.

Conclusion

Carbetocin is not a cost-effective choice in PPH prevention for both modes of delivery in the Philippines, unless price reduction is made. Our findings can be used for evidence-informed policies to guide coverage decisions on carbetocin not only in the Philippines but also in other low and middle-income countries.
How to adapt sexual and reproductive health services to the needs and circumstances of trans people— a qualitative study in Colombia
Authors: Calderón-Jaramillo Mariana , Mendoza Ángel , Acevedo Natalia , Forero-Martínez Luz Janeth , Sánchez Sandra Marcela , Rivillas-García Juan Carlos
Published: October 2020

Background

People living a trans-life require access to equitable healthcare services, policies and research that address their needs. However, trans people have experienced different forms of violence, discrimination, stigma, and unfair access barriers when dealing with healthcare providers. Therefore, adapting sexual and reproductive health services with the purpose of providing more equitable, inclusive and discrimination-free healthcare services is an urgent need. The article presents an example of how operative research can be used in order to adjust sexual and reproductive healthcare services to trans people’s needs, identities and circumstances.

Methods

This is a qualitative study written from a constructivist perspective, and it is based on the voices and experiences of trans people in four major cities in Colombia. The research used a combination of focus groups of discussion (n = 6) and in-depth interviews with trans people (n = 13) in Barranquilla, Bogota, Cali and Medellin. This research had two specific objectives: i) identifying the main sexual and reproductive health needs of people living a trans-life; and ii) generating new evidence in order to guide the adaptation of sexual and reproductive health services centered to trans people’s needs, identities, and circumstances. Qualitative data codification and analysis was using NVivo.

Results

Once access barriers to sexual and reproductive health services, unmet sexual and reproductive health needs were identified, the research helped define strategies to adapt sexual and reproductive health services to the needs, identities, and circumstances of people living a trans-life in Colombia. Amongst the main barriers found were healthcare costs, lack of insurance, stigmatization, discrimination and abuse by health care providers. Perhaps among the most notable sexual and reproductive health needs presented were trans-specific services such as sensitive assistance for the transition process, endocrinology appointments, and sex reaffirmation surgeries.

Conclusions

The evidence obtained from this research allowed Profamilia, a Colombian healthcare provider, to adapt the sexual and reproductive health services it provides to people living a trans-life in Colombia. Furthermore, it was possible for Profamilia to design and implement an inclusive sexual and reproductive health program that specifically addresses trans people’s needs, identities, and circumstances.
State-society nexus in Brazil and Venezuela and its effect on participatory governance efforts in health and other sectors
Authors: Mahmood Qamar , Muntaner Carles
Published: October 2020

Introduction

Participatory governance is about state and society jointly responsible for political decisions and services. The origins and trajectory of participatory governance initiatives are determined by the socio-political context and specifically the nature of state-society relations. Participation by communities in health interventions has been promoted globally as a strategy to involve citizens in health decision-making but with little success. Such participatory governance in health should be seen not as a strategy alone but as a political project in which organized communities challenge the status-quo in health.

Methods

This paper deals with the wider socio-political context of participatory governance initiatives. It uses comparative politics literature to analyze socio-political context in Brazil and Venezuela, historically spanning half century prior to 2015, to assess whether it was conducive to participatory governance. The focus of this paper’s analysis particularly is on the socio-political changes that were taking place in Brazil and Venezuela in the decades of the 1980s and 1990s. Those decades formed the bedrock on which the two countries experienced democratization and a socialist transformation that has lasted well into the first decade of the twenty-first century. The situation in the health sector is also described for the two countries showing a parallel trajectory to the wider political context and that reflected the political ideology. For this assessment, we use a contemporary framework called the ‘socialist compass’ which links dynamics of power relations in various ways among three domains of power, namely, state power, economic power, and social power. Socialist compass can be used to assess whether such reforms are moving towards or against social empowerment.

Conclusion

Our analysis reveals that both Brazil and Venezuela were moving in the direction of social empowerment until at least the year 2015, just before the political turmoil started engulfing the left-leaning regimes in both the countries.
Projected impact of diabetes on the Costa Rican healthcare system
Authors: Santamaría-Ulloa Carolina , Montero-López Melina
Published: October 2020

Introduction

Costa Rica, similar to many other Latin American countries is undergoing population aging at a fast pace. As a result of the epidemiological transition, the prevalence of diabetes has increased. This condition impacts not only individual lives, but also the healthcare system. The goal of this study is to examine the expected impact of diabetes, in terms of economic costs on the healthcare system and lives lost. We will also project how long it will take for the number of elderly individuals who are diabetic to double in Costa Rica.

Methods

CRELES (Costa Rican Longevity and Healthy Aging Study), a three-wave nationally representative longitudinal study, is the main source of data for this research (n = 2827). The projected impact of diabetes was estimated in three ways: length of time for the number of elderly individuals with diabetes to double; projected economic costs of diabetes-related hospitalizations and outpatient care; and years of life lost to diabetes at age 60. Data analyses and estimations used multiple regression models, longitudinal regression models, and Lee-Carter stochastic population projections.

Results

Doubling time of the diabetic elderly population is projected to occur in 13 calendar years. This will cause increases in hospitalization and outpatient consultation costs. The impact of diabetes on life expectancy at age 60 around the year 2035 is estimated to lead to a loss of about 7 months of life. The rapid pace at which the absolute number of elderly people with diabetes will double is projected to result in a negative economic impact on the healthcare system. Lives will also be lost due to diabetes.

Conclusion

Population aging will inevitably lead to an increasing number of elderly individuals, who are at greater risk for diabetes due to their lifelong exposure to risk factors. Actions to increase the quality of life of diabetic elderly are warranted. Decreasing the burden of diabetes on elderly populations and the Costa Rican healthcare system are necessary to impact the quantity and quality of life of incoming cohorts. Health promotion and prevention strategies that reduce diabetes risk factors are needed to improve the health of elderly populations.
CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc
Authors: Shen Shuying , Yao Teng , Xu Yining , Zhang Deguang , Fan Shunwu , Ma Jianjun
Published: October 2020

Background

Osteosarcoma (OS) is the most common malignant bone tumor and has a poor prognosis. The potential involvement of circular RNAs (circRNAs) in OS progression remains unexplored.

Here, we report that CircECE1, a circular RNA derived from human ECE1, plays a critical role in energy metabolism in OS.

Methods

The RIP chip sequence assay was performed to confirm CircECE1, through overexpression or knockdown of CircECE1 to verify its function in 143B and U2OS. RNA immunoprecipitation and immunoprecipitation were used to verify CircECE1’s regulation of protein c-Myc and co- immunoprecipitation was used to verified the competitive binding relationship between CircECE1 and SPOP. The influence of CircECE1 on energy metabolism was evaluated by seahorse experiment, western blot, and immunohistochemistry.

Results

We found that CircECE1 is highly expressed in OS tissues and cells and that CircECE1 knockdown suppresses tumor proliferation and metastasis both in vitro and in vivo. Further, CircECE1 significantly promotes glucose metabolism in OS cells in vitro and in vivo. Mechanistically, CircECE1 interacts with c-Myc to prevent speckle-type POZ-mediated c-Myc ubiquitination and degradation. C-Myc inhibits thioredoxin binding protein (TXNIP) transcription and subsequently activates the Warburg effect.

Conclusions

CircECE1 regulates the Warburg effect through the c-Myc/TXNIP axis. CircECE1 mediated signal transduction plays a important role in OS process and energy metabolism. These findings may identify novel targets for OS molecular therapy.
Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions
Authors: Navas-Pérez Enrique , Vicente-García Cristina , Mirra Serena , Burguera Demian , Fernàndez-Castillo Noèlia , Ferrán José Luis , López-Mayorga Macarena , Alaiz-Noya Marta , Suárez-Pereira Irene , Antón-Galindo Ester , Ulloa Fausto , Herrera-Úbeda Carlos , Cuscó Pol , Falcón-Moya Rafael , Rodríguez-Moreno Antonio , D’Aniello Salvatore , Cormand Bru , Marfany Gemma , Soriano Eduardo , Carrión Ángel M. , Carvajal Jaime J. , Garcia-Fernàndez Jordi
Published: October 2020

Background

One of the most unusual sources of phylogenetically restricted genes is the molecular domestication of transposable elements into a host genome as functional genes. Although these kinds of events are sometimes at the core of key macroevolutionary changes, their origin and organismal function are generally poorly understood.

Results

Here, we identify several previously unreported transposable element domestication events in the human and mouse genomes. Among them, we find a remarkable molecular domestication that gave rise to a multigenic family in placental mammals, the Bex/Tceal gene cluster. These genes, which act as hub proteins within diverse signaling pathways, have been associated with neurological features of human patients carrying genomic microdeletions in chromosome X. The Bex/Tceal genes display neural-enriched patterns and are differentially expressed in human neurological disorders, such as autism and schizophrenia. Two different murine alleles of the cluster member Bex3 display morphological and physiopathological brain modifications, such as reduced interneuron number and hippocampal electrophysiological imbalance, alterations that translate into distinct behavioral phenotypes.

Conclusions

We provide an in-depth understanding of the emergence of a gene cluster that originated by transposon domestication and gene duplication at the origin of placental mammals, an evolutionary process that transformed a non-functional transposon sequence into novel components of the eutherian genome. These genes were integrated into existing signaling pathways involved in the development, maintenance, and function of the CNS in eutherians. At least one of its members, Bex3, is relevant for higher brain functions in placental mammals and may be involved in human neurological disorders.
Parametric models analysed with linear maps
Authors: Matthies Hermann G. , Ohayon Roger
Published: October 2020

Parametric entities appear in many contexts, be it in optimisation, control, modelling of random quantities, or uncertainty quantification. These are all fields where reduced order models (ROMs) have a place to alleviate the computational burden. Assuming that the parametric entity takes values in a linear space, we show how is is associated to a linear map or operator. This provides a general point of view on how to consider and analyse different representations of such entities. Analysis of the associated linear map in turn connects such representations with reproducing kernel Hilbert spaces and affine-/linear-representations in terms of tensor products. A generalised correlation operator is defined through the associated linear map, and its spectral analysis helps to shed light on the approximation properties of ROMs. This point of view thus unifies many such representations under a functional analytic roof, leading to a deeper understanding and making them available for appropriate analysis.
Are weight status and weight perception associated with academic performance among youth?
Authors: Livermore Maram , Duncan Markus J. , Leatherdale Scott T. , Patte Karen A.
Published: October 2020

Background

Emerging evidence suggests perceptions of being overweight account for many of the psychosocial consequences commonly associated with obesity. Previous research suggests an obesity achievement gap, yet limited research has explored weight perception in association with academic performance. Moreover, underweight perceptions have typically been excluded from research. The current study examined how BMI classification and weight perception relate to academic performance in a large cohort of youth.

Methods

We used cross-sectional survey data from 61,866 grade 9–12 students attending the 122 Canadian schools that participated in Year 6 (2017/2018) of the COMPASS study. Mixed effect regression models were used to examine associations between students’ BMI classification and weight perceptions and their math and English/French course grades. All models were stratified by sex and adjusted for sociodemographic covariates and school clustering.

Results

For English/French grades, males and females with overweight or underweight perceptions were less likely to achieve higher grades than their peers with perceptions of being at “about the right weight”, controlling for BMI and covariates. For math grades, females with overweight perceptions, and all students with underweight perceptions, were less likely to achieve higher grades than their peers with “about the right weight” perceptions. All students with BMIs in the obesity range were less likely to report grades of 60% or higher than their peers with “normal-weight” BMIs, controlling for weight perception and covariates. Overweight BMIs were predictive of lower achievement in females for English/French grades, and in males for math grades, relative to “normal-weight” BMIs. Results for students that did not respond to the weight and weight perception items resembled those for obesity BMI and overweight/underweight perceptions, respectively.

Conclusions

Overall, this study demonstrates that an obesity achievement gap remains when controlling for students’ perceptions of their weight, and that both underweight and overweight perceptions predict lower academic performance, regardless of BMI classification. Results suggest barriers to academic success exist among youth with larger body sizes, and those with perceptions of deviating from “about the right weight”.
When clean eating isn’t as faultless: the dangerous obsession with healthy eating and the relationship between Orthorexia nervosa and eating disorders in Mexican University students
Authors: Parra Carriedo Alicia , Tena-Suck Antonio , Barajas-Márquez Miriam Wendolyn , Bilbao y Morcelle Gladys María , Díaz Gutiérrez Mary Carmen , Flores Galicia Isabel , Ruiz-Shuayre Alejandra
Published: October 2020

Introducción

La ortorexia nervosa es un trastorno de la conducta alimentaria que ha sido poco estudiado, tanto en sus características, causas y síntomas, como en sus consecuencias y en la relación con otros trastornos de la conducta alimentaria. El presente estudio tuvo como objetivo analizar dicha relación e indagar si es posible predecir la aparición de un trastorno de la conducta alimentaria a partir de la presencia de ortorexia nervosa, además de analizar diferencias por sexo en estudiantes universitarios mexicanos.

Método

Participaron en el estudio 911 estudiantes universitarios (65.4% fueron mujeres y el 34.6% hombres), en un rango de edades entre 18 y 28 años (M = 21 y DE = 1.9) que respondieron dos cuestionarios que son: ORTO-14MX, una versión del instrumento ORTO-15 previamente validada en estudiantes mexicanos y el EDE-Q en su versión corta, además de proporcionar algunos datos sociodemográficos de interés para este estudio.

Resultados

El análisis de correlación de Pearson reveló relaciones estadísticas significativas de leves a moderadas entre los factores que componen ambas escalas, mientras que el análisis de regresión lineal mostró un que un 40% de la varianza es explicada a partir de los factores que componen la escala ORTO-14MX en la muestra de estudio. Adicionalmente se encontraron diferencias estadísticamente significativas entre hombres y mujeres con respecto a todas las subescalas de los instrumentos que midieron ortorexia y trastornos de la conducta alimentaria.

Conclusiones

Estos resultados mostraron un grado de predicción moderada que sí bien es prometedora, no resulta totalmente concluyente. Asimismo, se confirmó que las mujeres siguen siendo más vulnerables a padecer ortorexia o un TCA. Se concluye la necesidad de continuar estudiando la relación entre la ortorexia y los TCAs, en muestras latinoamericanas con otras características socio demográficas y en población clínica.
Evaluation of the prophylaxis and treatment of COVID-associated coagulopathy
Authors: Elbeddini Ali , Gerochi Rachel , Elshahawi Ahmed
Published: October 2020

Most of the current “literature” surrounding the presence of thrombosis in COVID-19 disease and appropriate prophylaxis/treatment modalities is certainly retrospective at best, and anecdotal at worst. But in these times of rapidly changing information and perspective, an assessment of all available data (including expert opinion) is the goal of this review. Bleeding risk factors for COVID-19-associated bleeding may include other systemic diseases, including hypertension, diabetes, cardiovascular disease, and immunosuppression. Individuals with hypertension should not discontinue their medication. Current evidence does not support changes in the management of hypertension. As COVID-19 progresses, coagulation pathways are activated as part of the host inflammatory response to limit the viral infection. Specifically, D-dimers, products of fibrin as it is degraded within clots, are elevated in many cases of hospitalized COVID-19 patients. D-dimers are an indicator of a clot (thrombus) formation and breakdown. More severe COVID-19 disease may lead to overt disseminated intravascular coagulation (DIC), associated with high mortality. DIC is a coagulopathy that may arise from the systemic inflammatory response to the virus and damaged tissue caused by the infection. Bleeding risk factors may include other systemic diseases, including hypertension, diabetes, cardiovascular disease, and immunosuppression. Individuals with hypertension should not discontinue their medication. Current evidence does not support changes in the management of hypertension. As COVID-19 progresses, coagulation pathways are activated as part of the host inflammatory response to limit the viral infection. Specifically, D-dimers, products of fibrin as it is degraded within clots, are elevated in many cases of hospitalized COVID-19 patients. D-dimers are an indicator of a clot (thrombus) formation and breakdown. More severe COVID-19 disease may lead to overt disseminated intravascular coagulation (DIC), associated with high mortality. DIC is a coagulopathy that may arise from the systemic inflammatory response to the virus and damaged tissue caused by the infection. My manuscript presents the risk and evidence around the COVID-19-associated coagulopathies
Randomised feasibility trial and embedded qualitative process evaluation of a new intervention to facilitate the involvement of older patients with multimorbidity in decision-making about their healthcare during general practice consultations: the VOLITION study protocol
Authors: Butterworth Joanne , Richards Suzanne , Warren Fiona , Pitchforth Emma , Campbell John
Published: October 2020

Background

The number of older people with multiple health problems is increasing worldwide. This creates a strain on clinicians and the health service when delivering clinical care to this patient group, who themselves carry a large treatment burden. Despite shared decision-making being acknowledged by healthcare organisations as a priority feature of clinical care, older patients with multimorbidity are less often involved in decision-making when compared with younger patients, with some evidence suggesting associated health inequalities. Interventions aimed at facilitating shared decision-making between doctors and patients are outdated in their assessments of today’s older patient population who need support in prioritising complex care needs in order to maximise quality of life and day-to-day function.

Aims

To undertake feasibility testing of an intervention (‘VOLITION’) aimed at facilitating the involvement of older patients with more than one long-term health problem in shared decision-making about their healthcare during GP consultations.

To inform the design of a fully powered trial to assess intervention effectiveness.

Methods

This study is a cluster randomised controlled feasibility trial with qualitative process evaluation interviews. Participants are patients, aged 65 years and above with more than one long-term health problem (multimorbidity), and the GPs that they consult with. This study aims to recruit 6 GP practices, 18 GPs and 180 patients. The intervention comprises two components: (i) a half-day training workshop for GPs in shared decision-making; and (ii) a leaflet for patients that facilitate their engagement with shared decision-making. Intervention implementation will take 2 weeks (to complete delivery of both patient and GP components), and follow-up duration will be 12 weeks (from index consultation and commencement of data collection to final case note review and process evaluation interview). The trial will run from 01/01/20 to 31/01/21; 1 year 31 days.

Discussion

Shared decision-making for older people with multimorbidity in general practice is under-researched. Emerging clinical guidelines advise a patient-centred approach, to reduce treatment burden and focus on quality of life alongside disease control. The systematic development, testing and evaluation of an intervention is warranted and timely. This study will test the feasibility of implementing a new intervention in UK general practice for future evaluation as a part of routine care.

Trial registration

CLINICAL TRIALS.GOV registration number NCT03786315, registered 24/12/18
A feasibility pragmatic clinical trial of a primary care network exercise and education program for people with COPD
Authors: Hurley Kelsey M. T. , Selzler Anne-Marie , Rodgers Wendy M. , Stickland Michael K.
Published: October 2020

Background

Pulmonary rehabilitation is an important component of chronic disease management in chronic obstructive pulmonary disease (COPD) and has been shown to improve shortness of breath, exercise capacity, quality of life, and decrease hospitalizations. However, pulmonary rehabilitation capacity is low. Primary care may be an effective method for delivering disease management services to this population. The objective of this feasibility pragmatic clinical trial was to evaluate enrollment and completion of a primary care network exercise and education program for people with COPD.

Methods

COPD patients (N = 23; mean age = 65 ± 9 years; FEV1 = 68 ± 20% predicted) were recruited after referral to a primary care network exercise program in Edmonton, Alberta. Participants self-selected either an 8-week 16-session supervised exercise program or an 8-week unsupervised exercise program where they received three visits with an exercise specialist. Both groups self-selected education sessions with clinicians for disease management support. Referrals, completion, and program outcomes (physical activity, exercise capacity and health status) were measured before (T1), immediately after (T2), and 8 weeks following the program (T3).

Results

Forty-three referrals were received in 10 months, where a minimum of 50 was required in order for the program to be considered feasible. Twenty-three participants provided baseline data, and twenty participants started the exercise program (10 in each exercise group), 16 of which completed the exercise program (80%). On average, 48% of the recommended education sessions were completed by participants.

Conclusions

Enrollment into a COPD exercise and education program in a primary care network was low indicating the need for improved referral processes from physicians. Completion rates by participants were adequate for exercise but not education. The low referral rate and the lack of enrollment in COPD education by the patients indicate that a large-scale trial of the program as designed is not feasible.
The LaserFIB: new application opportunities combining a high-performance FIB-SEM with femtosecond laser processing in an integrated second chamber
Authors: Tordoff Ben , Hartfield Cheryl , Holwell Andrew J. , Hiller Stephan , Kaestner Marcus , Kelly Stephen , Lee Jaehan , Müller Sascha , Perez-Willard Fabian , Volkenandt Tobias , White Robin , Rodgers Thomas
Published: October 2020

The development of the femtosecond laser (fs laser) with its ability to provide extremely rapid athermal ablation of materials has initiated a renaissance in materials science. Sample milling rates for the fs laser are orders of magnitude greater than that of traditional focused ion beam (FIB) sources currently used. In combination with minimal surface post-processing requirements, this technology is proving to be a game changer for materials research. The development of a femtosecond laser attached to a focused ion beam scanning electron microscope (LaserFIB) enables numerous new capabilities, including access to deeply buried structures as well as the production of extremely large trenches, cross sections, pillars and TEM H-bars, all while preserving microstructure and avoiding or reducing FIB polishing. Several high impact applications are now possible due to this technology in the fields of crystallography, electronics, mechanical engineering, battery research and materials sample preparation. This review article summarizes the current opportunities for this new technology focusing on the materials science megatrends of engineering materials, energy materials and electronics.
Axillary nodal metastasis in ovarian cancer: a report of three cases and review of literature
Authors: Zuhdy Mohammad , Alghandour Reham , Abdelazeem Gena , Saleh Gehad A. , Saleh Mahmoud M. , Hamdy Mohamed , Hamdy Omar
Published: October 2020

Background

Ovarian cancer represents a major global health burden that is rarely associated with distant metastasis. Axillary lymph node metastasis from ovarian cancer is rare and is reported only in few case reports in literature.

Case presentation

We report three cases of ovarian carcinoma associated with axillary lymph node metastasis as well as a brief literature review. The pathologic subtype in one case was malignant mixed Mullerian tumor, while the other two cases were high-grade serous ovarian carcinoma. Axillary nodal metastasis was reported as a synchronous event in one case, while it was reported as recurrence events in the other two cases.

Conclusion

Physicians should be aware of this uncommon mode of metastasis in ovarian cancer cases. Multi-disciplinary discussion is crucial in the management of these cases to offer them the best suitable treatment.
Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis
Authors: Mostafa Hany Samir , Ayad Essam Ezzat
Published: October 2020

Background

Primary atrophic rhinitis (1ry AR) is a chronic nasal disease characterized by the loss of mucociliary clearance and presence of viscid secretions and dried crusts that causes a characteristic foul odor, usually bilateral. A large range of treatment modalities had been tried, yet there is still no agreement upon a curative treatment with long-lasting success. The purpose of the study was to assess the value of platelet-rich plasma as a biogenic stimulator for healing acceleration in primary atrophic rhinitis.

A total of 78 cases clinically diagnosed to have primary atrophic rhinitis were included. Nasal endoscopy, Sino-Nasal Outcome Test-25 questionnaire, mucociliary clearance assessment by saccharine transit time test, and biopsy specimens were achieved before 1 month and 6 months after the application of platelet-rich plasma in group A (cases) and platelet-poor plasma in group B (controls).

Results

All patients in group A showed endoscopic improvement and reduction in the incidence of the most frequently encountered symptoms before platelet-rich plasma injection including nasal crusts, 36 (92.30%); foetor, 31 (79.48%); nasal obstruction, 30 (76.92%); anosmia, 17 (43.58%); and epistaxis, 7 (17.94%) to nasal crusts, 9 (23.07%); foetor, 13 (33.33%); nasal obstruction, 14 (35.89%); anosmia, 13 (33.33%); and epistaxis, 3 (7.69%), 6 months after, and this was reflected in the reduction of the Sino-Nasal Outcome Test-25 scores which was averaged 40 before platelet-rich plasma to 9, 6 months after. Similarly, the mucociliary clearance time was significantly reduced after platelet-rich plasma injection; saccharine transit time test was initially averaged at 1980 s and got reduced to 920 s, 6 months after platelet-rich plasma injection.

Conclusion

The use of platelet-rich plasma as a biogenic stimulator is a possible innovative less invasive approach that can be effective in repairing tissue dystrophy through further future studies.
Source-domain full-waveform inversions
Authors: Wu Yulang , McMechan George A.
Published: October 2020

Conventional full-waveform inversion (FWI) updates a velocity model by minimizing the data residuals between the predicted and observed data at the receiver positions. We have developed a new FWI to update the velocity model by minimizing virtual source artifacts at the receiver positions in the source-domain FWI (SFWI). Virtual source artifacts are created by replacing the propagating source wavefield by the forward-time observed data at the receiver positions as a data-residual constraint. Therefore, no matter whether the velocity model is correct or not, the data residuals at the receiver positions always are forced to be zero. If the velocity model is correct, this data-residual constraint has no effect on the wavefield because the predicted data are the same as the observed data. However, if the estimated velocity model is incorrect, the mismatch between the replaced forward-time observed data and the incorrect predicted upgoing waves (e.g., the reflected waves) at the receiver positions will produce downgoing artifact waves. Thus, the data-residual constraint behaves as a virtual source to create artifact wavefields. By minimizing the virtual source artifacts (equivalent to producing the artifact wavefield), the velocity model can be iteratively updated toward the true velocity model. Similar to conventional FWI, SFWI can be implemented in either the frequency or time domain, which is unlike previous source-domain solutions which have to be implemented only in the frequency domain to solve the normal equations. SFWI does more overfitting of noisy observed data than conventional FWI does because noise is amplified by the differential operators when calculating the virtual source artifacts. Tests on synthetic data indicate that SFWI inverts for the velocity model more accurately than conventional FWI for noise-free or low-noise data.
Joint impedance inversion and spectral decomposition for deepwater gas reservoir characterization: A case study in South China Sea
Authors: Xiang Kun , Yang Yadi , Huang Handong , Luo Yaneng , Jiang Mengqi
Published: October 2020

Gas reservoir characterization is one of the frontiers in seismic exploration. Acoustic impedance, one of the most effective seismic attributes, aims to describe the spatial distribution of rock properties. However, using acoustic impedance only is insufficient to describe gas-bearing layers accurately, in the case of rapid lithologic changes and complex geology in the deepwater area. The reflection seismograms indicate an absorption effect when seismic waves propagate through gas-bearing layers. The absorption effect can be used as an additional attribute to help gas reservoir characterization. Therefore, we have developed a new attribute for gas reservoir characterization in this study, which integrates the results of acoustic impedance and absorption coefficient. We estimate the acoustic impedance model by using poststack impedance inversion and then we calculate probability distribution functions. Functions are classified into gas-bearing and nongas layers. We discuss an absorption coefficient and obtain it from the spectrum gradient, in which the gradient is calculated by spectral decomposition using the matching pursuit method. We apply the new attribute to characterize the spatial distribution and thickness of deepwater gas reservoirs in the Pearl River Mouth Basin. Well-log and geologic information indicate that the study area has an enrichment of gas reservoirs. Field data application indicates the explicit distribution of the gas reservoir and in accordance with the well-log information, which indicates that our attribute can improve gas reservoir characterization.