bluuebunny/crossref_metadata_2025 huggingface dataset:
Clusters of Cyclones and Their Effect on Coast Abrasion in Kaliningrad Region
Authors: Stont Zhanna , Esiukova E , Ulyanova Marina
Published: August 2023

The shores of the Kaliningrad Region (the Russian part of the South-Eastern Baltic Sea) are regularly exposed to extreme storms, which leads to intensive abrasion and flooding of the land. Based on archival data, meteorological monitoring, forecast and synoptic maps, an analysis of extreme storms observed in the autumn-winter periods of the early 21st century was done. The cyclone type was determined using the HYSPLIT (Hybrid Single Particle Lagrangian Integrated Trajectory Model), which makes it possible to reconstruct the trajectory of the approach of the atmospheric vortex to the coast. The seasons with clusters of storms were identified, when deep cyclones affected the coasts of the Kaliningrad Region in a relatively short time. Regardless of the type of trajectory, storms cause destruction of both natural and infrastructure objects. But the shores of the northern exposure are most susceptible to destruction by “diving” cyclones, the wave regime of which has a high potential energy. Earlier it was noted that the frequency of cyclones with northerly winds increases. Clusters of northern cyclones are especially dangerous, as was in January 2022, when 4 atmospheric eddies affected the coast with an interval of several hours to 2–3 days. When the water level was high, the waves crashed on the coast, causing catastrophic damage. The coastal monitoring revealed numerous destruction of the banks, breakthroughs of the foredune, both flooding and collapse of forests, critical damage to coast protection and engineering structures, and infrastructure facilities. Dozens of hectares of coastal territories have been lost. There are environmental problems associated with numerous emissions into the marine environment of a huge amount of anthropogenic mega-, macro-, meso-, micro-garbage with a predominance of plastic after extreme storms.
Extraction of Java Lemongrass (Cymbopogon citratus) Using Microwave-Assisted Hydro Distillation in Pilot Scale: Parametric Study and Modelling
Authors: Variyana Yeni , Ma'sum Zuhdi , Bhuana Donny Satria , Mahfud Mahfud
Published: August 2023

This study aims to extract oil from Java lemongrass (Cymbopogon citratus) using the pilot-scale Microwave-Assisted Hydro distillation method (distiller volume 10,000 mL). The operating variables of this research are the extraction time, the microwave power, and the ratio of the mass of the material to the solvent (F/S ratio). The results showed an increase in the yield of lemongrass oil along with the increase in extraction time using the Microwave-Assisted Hydro distillation (MAHD) method, and this trend will continue to occur as microwave heating is selective and volumetric. Thus, there is a tendency to increase yield with increasing power. In general, it follows that the higher the power, the higher the yield. The energy received by the material to be converted into heat has caused the essential oil yield to be more abundant, with the highest yield being obtained at 800 W. The increase in the material to solvent ratio increased the oil yield up to a certain point. However, the yield started declining after the F/S ratio of 0.08 was reached. The first order kinetic model well represents the extraction process at a pilot scale. The pilot scale's oil yield is slightly lower than the laboratory scale MAHD. Compositional analysis of the result suggests that the main components of Java lemongrass oil are Geranial (30.06%), Z-Citral (25.88%), Eugenol (12.88%), and Beta-Myrcene (12.84%).
The Translation of Culture-Specific Items (CSIs) in Yellow River Cultural Corpus: A Case Study of History of the Yellow River
Authors: Tian Chaonan
Published: August 2023

By constructing a bilingual parallel corpus from scratch and taking History of the Yellow River as an illustrative bilingual text, this study delves into the translation techniques applied to Culture-Specific Items (CSIs) within the framework of the Yellow River Basin civilization. The findings reveal a diverse range of approaches employed by translators, including literal translation, free translation, intracultural adaptation, omission, retention and annotation, especially in handling CSIs related to ecology, material culture, social life, religion, and language within the context of Yellow River culture. These techniques effectively preserve the intrinsic traits of the source language, thereby facilitating the propagation of Yellow River culture. The utilization of corpus-based research methodologies to analyze the English translation of CSIs in the Yellow River culture not only aligns with the essential imperatives of promoting Chinese culture on the global stage but also addresses the intricate nuances demanded by international communication.
Computer-Based Feedback (CBF) in Writing Classes as Perceived by Saudi EFL Students
Authors: Bimahboob Thamer A.
Published: August 2023

This study examines how Saudi EFL students feel about using CBF in their writing classes and what they think it can offer them as a learning tool. The research method is descriptive-analytic, and a questionnaire is used to collect responses. Sixty-five Saudi English as a Foreign Language (EFL) students from the fourth year of the English language program at King Saud University in Riyadh make up the study population. The entire research population constitutes the sample for this study. The findings indicate that Saudi EFL students positively perceive CBF in their writing classes. They perceive CBF as beneficial for improving their revision process, reducing the workload associated with error correction, and providing insightful comments. The students also believe that CBF saves time and effort while offering sufficient explanations for errors. In addition, the results show that Saudi EFL students view CBF favorably and choose to implement it in their writing classes. However, the study emphasizes enhancing students’ awareness of CBF and training them on its optimal use. The study suggests that integrating CBF tools into writing classes can provide positive learning experiences, but instructors should ensure that students receive proper training to utilize CBF effectively.
Augmentation of a multidisciplinary team meeting with a clinical decision support system to triage breast cancer patients in the United Kingdom
Authors: Martin Martha , Kristeleit Hartmut , Ruta Danny , Karampera Christina , Hekmat Rezzan , Felix Winnie , InHout Bertha , Kothari Ashutosh , Kazmi Majid , Ledwaba-Chapman Lesedi , Clery Amanda , Wang Yanzhong , Coker Bola , Preininger Anita M , Vergis Roy , Eggebraaten Thomas , Gloe Chris , Irene Irene Dankwa-Mullan , Jackson Gretchen Purcell , Rigg Anne
Published: August 2023

Aim: Multidisciplinary team (MDT) meetings struggle with increasing caseloads. Recent National Health Service (NHS) guidance proposes that patients are triaged for ‘no discussion at MDT’. We examine whether an artificial intelligence (AI)-based clinical decision-support system (CDSS) can support human triage. Methods: Local best practice breast cancer MDT treatment decisions were compared with treatment decisions made by: two, two-person MDT triage teams with and without the CDSS; the CDSS acting ‘alone’; and the historical MDT. A decision tree on whether to triage patients to the CDSS or the MDT was created using supervised learning algorithms. Results: When localized, the CDSS achieved high concordance with local best practice (treatment plan decisions: 92% CDSS vs 96% team 1 vs 92% team 2, not significant [NS]; treatment type decisions: 89% CDSS vs 93% team 1 vs 82% team 2, NS). Using a decision tree 40.2% of cases can be correctly triaged to the CDSS for a treatment plan, and 34.6% for treatment type recommendations. Conclusion: AI-enabled CDSSs can potentially reduce the clinical workload for a breast cancer MDT by up to 40%. Before routine deployment they need to be appropriately localized and validated in prospective studies to evaluate clinical effectiveness and economic impact.
A clinician's guide to large language models
Authors: Briganti Giovanni
Published: August 2023

The rapid advancement of artificial intelligence (AI) has led to the emergence of large language models (LLMs) as powerful tools for various applications, including healthcare. These large-scale machine learning models, such as GPT and LLaMA have demonstrated potential for improving patient outcomes and transforming medical practice. However, healthcare professionals without a background in data science may find it challenging to understand and utilize these models effectively. This paper aims to provide an accessible introduction to LLMs for healthcare professionals, discussing their core concepts, relevant applications in healthcare, ethical considerations, challenges, and future directions. With an overview of LLMs, we foster a more collaborative future between healthcare professionals and data scientists, ultimately driving better patient care and medical advancements.
The biote-bot hybrid. The ultimate biothreat merging nanobots, AI-enabled cybernetics and synthetic biology
Authors: Kambouris Manousos E , Manoussopoulos Yiannis , Velegraki Aristea , Patrinos George P
Published: August 2023

The paper intends to warn stakeholders, by using open sources, of the possibility of extremely small, nano-/pico-aerial vehicles controlled locally or remotely by artificial intelligence mindsets to deliver, on specific hosts and tissues, either diverse bioagents produced by conventional and synthetic (micro)biology, including xenobiota or bionic microbiota or existing microbiota selected from natural reservoirs. The accuracy in delivery would leverage minute quantities of pathogens to cause mass-scale bioevents. Such hybrids (biote-bots) would increase the effectiveness of unfit but virulent pathogens, preserve the carried biota for the trip and contain bioagents' weaponization footprint to levels below the detection threshold of current regimes, while complicating immune response and denying pre-infection detection and identification. To respond, we suggest that novel diagnostics and surveillance amenities are needed, prompting cooperation of experts from Medicine, medical instruments/diagnostics, artificial Intelligence and from disciplines tackling cybernetics, remote sensing, surveying and tracking.
Women Entrepreneurship in MSME Sector
Authors: Goel Dr. Shuchi , Mittal Dr. Santosh
Published: August 2023

Abstract: Women's empowerment is now a global movement, and along with social and political empowerment, economic empowerment is of utmost importance for women in India. Focus challenges on all these fronts, acting in part as an invisible force and attempting to steer the course of women's empowerment in India in all conceivable milieus, including domestic, professional, financial, and political to combat this unstoppable force known as patriarchal mindset. For the purpose of empowering women and resolving their socioeconomic and employment issues, the Ministry of Micro, Small, and Medium companies (MSME) is placing more emphasis on creating substantial work opportunities for them through various industries and companies.This paper focus on various variables that prioritize women's empowerment, numerous government efforts and programs, schemes, information on MSMES and cutting-edge technology, and education for women in business.
The influence of social support on academic performance: The mediating role of cognitive engagement
Authors: Achdiyah Heni Nur , Latipun Latipun , Yuniardi Muhamad Salis
Published: August 2023

Academic performance, which measures a student’s success in learning, is influenced by various factors. One of the most important determinants of academic performance is social support. Parents, teachers, and friends all play a critical role in providing the necessary support that affects students’ cognitive engagement. Therefore, this study aimed to determine the relationship between social support and academic performance, which could be directly or indirectly mediated by cognitive engagement. The subjects used were 228 high school students in 11th grade, aged 15-18. Data were measured using Academic Performance Rating Scale (APRS), Child and Adolescent Social Support Scale (CASS), and Students Engagement Scale (SES) with Cronbach’s alpha values of 0.84, 0.93, and 0.88, respectively. The mediation analysis was conducted using the PROCESS model 4 developed by Hayes. The results showed that the relationship between social support and academic performance occurred through the mediation of cognitive engagement (β = 0.16), with no direct correlation (β = 0.12, p = 0.350). Specifically, more excellent social support was associated with increased cognitive engagement (β = 0.50, p = 0.000), leading to improved academic performance (β = 0.32, p = 0.005). Therefore, it was confirmed that social support is essential to students’ cognitive engagement and academic performance.
Experience of stress and job satisfaction among government and private elementary school teachers
Authors: Kamil Nur Kamalia Mohd , Olagoke Salami Mutiu
Published: August 2023

Changes in the teaching methods of students, especially during the COVID-19 crisis phase and the endemic transition, caused increased teacher stress. Therefore, this study examines the relationship between teacher stress and job satisfaction among government and private elementary school teachers. This study used a cross-sectional survey design in which elementary school teachers in Gombak were selected by convenience sampling. One hundred and fifty elementary school teachers participated in this study, including 75 government and 75 private elementary school teachers. The online questionnaire consists of the Teacher Stress Inventory (TSI) and the Short-Form Minnesota Questionnaire (MSQ). Descriptive analysis, Pearson’s correlation, and the independent t-test were used to find the relationship between teacher stress and job satisfaction and the difference between teacher stress and job satisfaction between government and private elementary school teachers. Findings revealed a negative correlation between teacher stress and job satisfaction [r(148)= -0.23, p = 0.005]. Furthermore, there is a significant difference in teacher stress and job satisfaction between government and private elementary school teachers [t(148) = 2.50, p = 0.014]. Private school teachers have been found to have higher teacher stress and job satisfaction than government school teachers. Although, with some limitations, the present study has contributed to existing knowledge and literature identifying why teachers’ well-being needs greater attention, as well as alarming the management of both private and government schools, providing avenues to reduce the stress level among teachers in promoting job satisfaction and enhancing teaching effectiveness.
The role of duration of dating on anxiety and commitment in early adulthood
Authors: Ulya Rifqi , Pratama Muhammad Fikri , Chusairi Achmad
Published: August 2023

This study aims to investigate the role of the duration of dating on anxiety and commitment in early adulthood. The study involved 172 early adults (aged 20-30 years) who are currently in romantic relationships, selected using a purposive sampling technique. The research instruments included the anxiety scale and commitment scale, based on previous theoretical aspects. Data analysis was conducted using Two Way ANOVA with JAMOVI software to examine the role of the duration of dating on anxiety and commitment. The results of the study showed that there was no significant role of the duration of dating on anxiety and commitment. The study also examined the relationship between the duration of dating and several demographic variables such as gender, occupation, and long-distance relationship (LDR), but no significant effects were found. Therefore, it can be concluded that the duration of dating, whether long or short, does not play a role in the anxiety and commitment of couples in maintaining romantic relationships at a more serious level, such as marriage. The duration of dating was found to be unable to predict anxiety and commitment in relationships. Other variables related to dating, such as relationship quality, satisfaction, and personal factors, are considered to be more involved in predicting anxiety and commitment in dating relationships. This study has practical implications as a reference in premarital counseling and couples therapy to understand the dynamics of romantic dating relationships in individuals.
Resiliência e adesão à terapia antirretroviral em pessoas vivendo com HIV: Revisão integrativa
Authors: Carvalho Patrícia Paiva , Rossato Lucas , Scorsolini-Comin Fabio
Published: August 2023

O objetivo desta revisão integrativa de literatura foi sintetizar as evidências disponíveis sobre o papel da resiliência na adesão à terapia antirretroviral em pessoas vivendo com HIV. Um comitê de juízes independentes realizou buscas sistematizadas nas bases/bibliotecas CINAHL, LILACS, PePSIC, PsycINFO, PubMed, SciELO, Scopus e Web of Science. Os dados foram organizados no software Rayyan. Foram recuperados 14 artigos publicados entre 2010 e 2021. Os resultados foram apresentados quanto à abordagem e nível da adesão, abordagem da resiliência e associação entre resiliência e adesão. Observou-se, em todos os estudos, que a resiliência esteve envolvida no processo de adesão à TARV, além do uso de diferentes abordagens conceituais acerca da resiliência, com predomínio de uma compreensão processual do construto e escassez de instrumentos de mensuração. A revisão de literatura evidenciou que poucos estudos avaliaram a resiliência em PVHIV e principalmente a relação entre resiliência e adesão, apesar do reconhecimento de que a resiliência pode modular a capacidade da pessoa de lidar com os estressores do viver com HIV e seus cuidados em saúde.
Techno-technologized world in the light of paradigmatic philosophical and methodological principles
Authors:   South Ural State University (National Research University), Solomko Dmitry
Published: August 2023

Introduction. The human world is presented as an integrity — an organic unity of many inter- connected and interdependent centers (parts, sides, elements): natural and cultural, natural and artificial, animate and inanimate. When any center dominates over others (for example, technical and technological) and / or attempts to realize its claim to the status of a whole, the agreed and optimal ra- tio in the coexistence and synergistic development of all centers, and, consequently, of the whole, is violated. There arises an ecosystem problem. The purpose of the study is to present and analyze the techno-technologized world in the context of current philosophical and scientific methodologi- cal principles: polycentricity, complexity, network- centricity, and ecosystem; to designate their theoretical and practical significance, interdepend- ence; to substantiate the principle of ecosystems as more general and fundamental and to present its effectiveness in preserving the integrity of man, his world and the full value of human being-in-the- world. Methods. The author uses methods of dialectics, synergetics and systemic approach in the philo- sophical understanding of the specifics of the modern techno-technological world and a person’s existence in it. The author also uses the methods of extrapolation and interpretation, the ideas of B. Latour’s actor-network theory, and ecosystem approach. Scientific novelty of the research. The author projects the key attitudes and concepts of the actual conceptual and paradigm principles on the techno-technological world, and formulates the main advantages and disadvantages. The author substantially justifies that the principle of ecosys- tem is the most effective in solving the problem of preserving and reproducing the integrity of the human world, the person himself and his being. Results. The author carries out theoretical and methodological analysis of the techno-technolo- gized world and a person’s existence in it. It has been determined that when solving the problem of preserving and reproducing the integrity of a person and his world, the principle of ecosystems is the most effective and preferable. The ecosystem principle implies the synergistic unity of all centers of human existence, their interdependence and interconnection, ensures the priority of the whole for the benefit of each center, expressed in mutual strengthening and expansion of their potential. Conclusions. The author comes to the conclusion that the application of relevant paradigm principles in studying and analyzing the techno-technological world will make it possible to obtain a more mul- tidimensional and accurate interpretation of the ways and means of achieving a full-fledged human being, with a focus on preserving his identity, origi- nality, subjectivity and integrity.
Two approaches to social policy in the German conservative political philosophy of the late XX century
Authors:   RAS Institute of philosophy, Podolskiy Vadim
Published: August 2023

Introduction. In conservative political philoso- phy in Germany at the end of the 20th century, there developed two main approaches to social policy. The first one, paternalistic and corporat- ist approach continued the line that had been established in the 19th century and assumed the active participation of the state in regulating social support. The second, the market one, adopted American ideas of the second half of the 20th cen- tury and proposed limiting the scope of the welfare state in order to save resources and avoid a nega- tive impact on the labor market. The purpose of the study is to analyze the argu- ments of the two directions of German conserva- tism at the end of the 20th century, their philo- sophical origin and their significance for politics. Methods. The article is based on the comparative historical approach, analysis of institutions and legal documents, and the hermeneutic method for studying the political, administrative and ideological context of the development of German conserva- tism at the end of the 20th century. Scientific novelty of the research. The article focuses on the intellectual heritage of German theorists, while the main attention of domestic and foreign researchers of conservative political philosophy of the late 20th century was attracted by American and British authors. Results. The key arguments of the paternalistic approach to social issues include pointing out the responsibility of elites for the well-being of the population and a strong state as a means of com- pensating for inequality in society. The arguments of the market approach are based on the appeal to the ideas of civic virtue and the protection of property as key forces that ensure social peace and well-being. Conclusions. In practice, the approach that offered the preservation and expansion of the welfare state prevailed, and favorable economic condi- tions, as well as institutional and ideological inertia, contributed to implementing solutions within the framework of this paradigm. But the ideas of the market approach have not lost their relevance, since the burden on the welfare state increases due to the aging of the population.
Proposição de critérios para priorização dos processos internos das IFES
Authors: Barros Fernando Rufino de , Nunes Ester Peixoto , Morais Alline Sardinha Cordeiro
Published: August 2023

As Instituições Federais de Ensino Superior são cada vez mais obrigadas a adotarem ferramentas para a melhoria dos processos internos. Nesse sentido, o presente estudo tem por objetivo apresentar um conjunto de critérios para priorização dos processos sob diferentes aspectos e áreas da gestão, de forma a contribuir para o cumprimento das diferentes exigências do contexto educacional público. Após a condução do estudo, propõe-se a utilização de doze critérios que revelam a complexidade, desempenho e características dos processos. À medida que esses critérios se alinham aos atos normativos que regulam as diferentes áreas da instituição, eles também proporcionam maior visibilidade e controle dos processos, melhorando o desempenho e os resultados entregues, tanto do ponto de vista interno quanto externo. O documento detalha os objetivos de cada critério, demonstrando como poderá impactar positivamente nas demais áreas.
Parámetros que definen la velocidad de diseño de carreteras en terreno ondulado
Authors: Oñate-Bastidas Carlos Eduardo , Calero-Valenzuela Carlos Anibal
Published: August 2023

En Colombia, la cantidad de choques fatales evidencian un problema de seguridad vial, la consistencia de diseño geométrico pudiera ser una solución para su disminución, dado que están directamente relacionadas. El Manual de Diseño Geométrico de Carreteras de Colombia pretende encaminar la consistencia en una etapa temprana del diseño a través de la asignación de la velocidad específica para los elementos en planta y perfil. El objetivo de este estudio es verificar la aplicabilidad de los parámetros que definen esta velocidad en curvas horizontales para terreno ondulado. Se analizaron 40 curvas horizontales en las que se registraron 1380 datos de velocidad con usuarios circulando a flujo libre. Se consideraron los elementos geométricos y operacionales como variables independientes, y los cambios de velocidad como variables dependientes. El análisis de varianza multifactorial realizado a un grupo de combinaciones de variables categorizadas determinó que la velocidad de diseño es más sensible al parámetro velocidad de operación en la curva anterior (Voi-1) con coeficientes R2 entre 63% y 75%, y al parámetro geométrico ángulo de deflexión (Δ) con coeficientes de determinación R2 entre 43% y 56%. Se concluye que el Manual de Diseño Geométrico de Carreteras requiere cambios metodológicos en la asignación de velocidades específicas y se propone una nueva metodología para la asignación de velocidades específicas para terreno ondulado.
Estado del arte enfocado a los componentes térmicos que conforman un banco de pruebas para turbocargadores
Authors: Bermúdez-Santaella José Ricardo , Suarez –Sierra Oscar Javier , Cabello-Eras Juan José
Published: August 2023

En este escrito se presenta un enfoque del estado del arte de los procesos térmicos que conforman un banco de pruebas para turbocargadores vehiculares, donde se clasifican según su fuente de energía, como la proveniente de un motor de combustión interna, o de un flujo frio, o de un sistema de calentamiento por resistencias o cámara de combustión por gas. La revisión sistemática de artículos científicos consultados a través del gestor de la base de datos Mendeley, sin restricción de fecha, en los idiomas español e inglés, del cual se incluyó literatura gris mediante búsqueda manual por medio Google Académico, también se revisaron sus resumenes y en los casos necesarios los artículos completos, teniéndose en cuenta finalmente los artículos que incluyen recomendaciones sobre los modelos matemáticos de proceso referentes a los turbocargadores, cámara de combustión, filtros y plenum. Los documentos escogidos fueron un total de 90, clasificados 20 en el primer grupo como, bancos de pruebas para turbocargadores y el segundo grupo son 57 que corresponde a los componentes que conforman un banco de prueba. Estos documentos estan ubicandos en el tiempo por años, para el primer grupo desde 2002 hasta el 2019 y el segundo grupo desde el 2005 hasta 2021.
A study on customer loyalty to service quality in independent auditing firms
Authors: Nguyen Hoan , Hoang Dinh Huong , Do Duc Tai , Tran The Nu , Dao Truong Thanh , Vu Hung Phuong
Published: August 2023

Auditing quality is the level of customer satisfaction with the objectivity and reliability of the audit service (Ministry of Finance, 2012). This study explores the relationship between service quality and the loyalty of customers in Vietnamese domestic independent auditing firms. This study was conducted in Hanoi, Vietnam, based on a sample of 250 general accountants and chief accountants who are working for customer firms with transactions at Vietnamese domestic independent auditing firms in Hanoi city. Based on the collected data, we run Cronbach’s alpha, exploratory factor analysis (EFA), Kaiser-Meyer-Olkin (KMO) test, Barlett’s test, and regression using SPSS software. The results show that service quality positively affects the loyalty of customers (LOY), including reliability (REL), responsiveness (RES), assurance (ATT), empathy (EMP), and tangibility (TAN). Moreover, it recognizes the higher weight of customer loyalty in firms. The research determined that service quality can promote customer loyalty. Besides, the services of domestic independent auditing firms have many different characteristics compared to other industries. Therefore, there is a need for more studies on the relationship between service quality and customer loyalty in the audit field. From there, it contributes to perfecting the theoretical framework on customer loyalty and is a useful reference for domestic independent auditing firms, auditors, and audit researchers.
Real-world evidence of antipsychotic monotherapy vs. polypharmacy in the treatment of schizophrenia spectrum disorders: Risk of hospitalisation from the emergency department
Authors: KORKMAZ ŞÜKRÜ ALPEREN , Koca Esra , Yılmaz Özge , Özbek Tayfun , Güçlü Muhammed
Published: August 2023

Introduction: Although it is known that antipsychotic non-compliance
increases the risk of emergency department (ED) utilisation,
presentation with agitation/aggression and rehospitalisation in
schizophrenia spectrum disorders (SSD) patients, it is unwell known
whether antipsychotic monotherapy vs. polypharmacy differs in terms of
efficacy in these domains. This study aimed to determine the
effectiveness of antipsychotic monotherapy and polypharmacy for the
prevention of hospitalisation who admitted to the ED in the real-world.
Methods: The study was conducted with electronic health records of 669
SSD patients admitted to the ED between 2019 and 2022. Patients were
evaluated in four groups according to antipsychotic use at the first
admission to the ED: antipsychotic non-compliance for more than 90 days,
antipsychotic non-compliance for 15-90 days, antipsychotic monotherapy
and polypharmacy. All antipsychotics and other psychotropic drugs used
by the patients were also recorded and followed up for at least one year
after index admission. Results: The groups, including patients with
antipsychotic non-compliance, had higher ED visits, more
hospitalisations and more admissions with agitation/aggression compared
to antipsychotic monotherapy or polypharmacy. However, no differences
were found between monotherapy and polypharmacy groups regarding these
outcomes. Patients discharged with monotherapy or polypharmacy also had
similar re-hospitalisation rates at follow-up. Conclusions: There is no
positive evidence that recommending polypharmacy over antipsychotic
monotherapy is superior in the frequency of ED visits, ED admissions
with agitation/aggression, hospitalisation and re-hospitalisation. In
this context, it may be more feasible to clozapine monotherapy before
antipsychotic polypharmacy in treatment-resistant patients due to more
significant evidence.
Sense of Coherence is Associated with Functional Impairment in Individuals Diagnosed with ADHD
Authors: Dayan Haym , Khoury-Kassabri Mona , Pollak Yehuda
Published: August 2023

Aims: People diagnosed with ADHD are in a higher risk for
anti-social behaviors, substance abuse, emotional distress, and low
happiness. It is necessary to know about factors that can predict the
increased risk of these comorbidities as well as the protective factors
that can be implemented therapeutically, for the purpose of reducing the
risk of these functional impairments. Sense of coherence (SOC) was found
to protect against various risk factors and health conditions. The
present study examined whether SOC correlates with better functioning
among adults and adolescents diagnosed with ADHD. Methods: 468
participants aged 15-50, who reported being diagnosed with ADHD,
answered an online survey that included validated questionnaires
regarding SOC and functional impairment in the following domain:
anti-social behaviors, substance abuse, emotional distress, and low
happiness. Results: Participants who reported a higher SOC also
reported lower functional impairments in all domains. The association
between SOC and outcome variables was similar in both genders and in
both adolescents and adults. Conclusions: SOC is central for
predicting various functional impairments among individuals diagnosed
with ADHD. These findings have practical implications for the detection
of an at-risk subgroup within the ADHD population and may inform the
development of interventions aimed at increasing SOC for people with
ADHD. The findings should be further tested in longitudinal and
intervention studies.
Investigation of Applicable Control Methods on Quadrotor Model
Authors: BUDAK Serkan , SUNGUR Cemil , DURDU Akif
Published: August 2023

Unmanned Aerial Vehicles are subject to a range of disturbances during
flight, including sensor noise, strong winds and turbulence, nonlinear
pattern changes, and time delays. These effects can have a significant
impact on the flight quality and control of Unmanned Aerial Vehicles. As
a result, there has been a growing interest in researching Unmanned
Aerial Vehicle control methods. Among the various types of Unmanned
Aerial Vehicles, quadrotor Unmanned Aerial Vehicles have become an ideal
choice for the generation and development of control algorithms, due to
their nonlinearity and susceptibility to disturbances. In this study, a
quadrotor model was developed and compared with linear and nonlinear
control algorithms. Linear and nonlinear control designs were developed
using the obtained model, and orientation control of the quadrotor was
achieved. Among the linear control methods, Proportional Integral
Derivative and Linear Quadratic Regulator were preferred, while Sliding
Mode Control was preferred among the nonlinear control methods. The
performance and step responses of the designed controllers were then
observed.
Acetaminophen: For its mechanism of analgesic action in vivo using molecular docking
Authors: Alaskiry Haider
Published: August 2023

Abstract Paracetamol is the most widely used drug in the world, but its
mechanism of action is unknown. As shown in new studies, it has a novel
metabolism, via a metabolic pathway that involves generation of an
active aminophenol metabolite through its metabolism in the liver by
acylamides/N-D-acetylases, and paracetamol metabolism. to its hepatic
metabolism CYP2A6. As the experiments were conducted using the molecular
docking program, where the dopamine receptors were linked with the new
metabolite, paracetamol, and the study showed compatibility during the
binding, and this indicates that the mechanism of action of paracetamol
is through the dopamine D2 receptors. Thus, the mechanism of action of
its analgesic and antipyretic effect depends on the activation of
dopamine D2 receptors through two mechanisms of action. This paper
describes experimental data that demonstrated the involvement of these
two metabolic pathways in the analgesic and antipyretic action of
paracetamol and its relationship to dopamine D2 receptors. It also
explains how new targets and systems play an important role in the
action of paracetamol. Finally, pain and antipyretic treatment
strategies.
Declining Incidence Rates of Distal Symmetric Polyneuropathy in People With Type 1 and Type 2 Diabetes in Denmark, With Indications of Distinct Patterns in Type 1 Diabetes
Authors: Mizrak Hatice Isik , Hansen Tine Willum , Rossing Peter , Curovic Viktor Rotbain , Vistisen Dorte , Amadid Hanan , Hansen Christian Stevns
Published: August 2023

OBJECTIVE

It is not known if incidence rates for diabetic distal symmetric polyneuropathy (DSPN) are decreasing, as they are for other diabetic complications. Here, we investigated incidence rates of DSPN in type 1 and type 2 diabetes in a large population-based study.

RESEARCH DESIGN AND METHODS

In the period 1996 to 2018, 19,342 individuals were identified at a Danish tertiary diabetes center. Vibration perception threshold was assessed by biothesiometry and repeated throughout the study. Exclusion of prevalent DSPN cases or missing data left data on 9,473 individuals for analysis of DSPN using a cutoff of >25 V and on 2,783 individuals for analysis using an age-, sex-, and height-specific cutoff. Poisson regression analysis was used to model incidence rates of DSPN for both cutoff types and separately for diabetes types. Covariates were sex, age, diabetes duration, and calendar time.

RESULTS

Incidence rates (95% CI) of DSPN decreased from 1996 to 2018 (e.g., from 4.78 [3.60–6.33]/100 person-years [PY] to 1.15 [0.91–1.47]/100 PY for 40-year-old men with type 1 diabetes and from 16.54 [11.80–23.18]/100 PY to 8.02 [6.63–9.69]/100 PY for 60-year-old men with type 2 diabetes, when using >25 V as the cutoff value). Analyses using age-, sex-, and height-specific cutoff values demonstrated similar incidence patterns by calendar time without sex differences. For type 1 diabetes, decreasing incidence rates were seen with older age.

CONCLUSIONS

Incidence rates for DSPN are declining in type 1 and type 2 diabetes, possibly due to improved diabetes treatment. This causality remains to be explored. Distinct age-related patterns indicate that the pathophysiology of DSPN may differ between diabetes types.
Emergency Department Use in Black Individuals With Diabetes
Authors: Rovner Barry , Casten Robin , Nightingale Ginah , Leiby Benjamin E. , Kelley Megan , Rising Kristin
Published: August 2023

Objective

The prevalence of diabetes is higher in Black than in White individuals, and Blacks seek emergency department (ED) care for diabetes more often than Whites. This randomized controlled trial compared the efficacy of a novel intervention called the Diabetes Interprofessional Team to Enhance Adherence to Medical Care (DM I-TEAM) to usual medical care (UMC) to prevent return diabetes-related ED visits and hospitalizations over 12 months in 200 Black individuals with diabetes after an ED visit. The trial also identified baseline variables associated with return ED visits and hospitalizations.

Methods

The DM I-TEAM provided diabetes education and behavioral activation services delivered by race-concordant research assistants, telehealth visits with a diabetes care and education specialist and primary care physicians, and clinical pharmacist recommendations.

Results

Participants had a mean age of 64.9 years, and 73.0% were women. There was no treatment group difference in return diabetes-related ED visits or hospitalizations over 12 months (DM I-TEAM n = 39 [45.3%] vs. UMC n = 37 [38.5%], χ2 = 0.864, P = 0.353). Baseline variables that were associated with return diabetes-related ED visits or hospitalizations were longer duration of diabetes, higher number of chronic health conditions, higher number of previous ED visits or hospitalizations, greater anticholinergic medication burden, lower satisfaction with primary care physicians, and lower trust in physicians (all P ≤0.05).

Conclusion

Among Black individuals with diabetes, the DM I-TEAM interprofessional intervention was no better than UMC at preventing return diabetes-related ED visits or hospitalizations. High medical morbidity, greater anticholinergic medication burden, low satisfaction with primary care physicians, and physician mistrust were associated with diabetes-related ED visits or hospitalizations independent of treatment. Before clinical interventions such as the DM I-TEAM can be effective, reducing system-level barriers to health, improving physician-patient relationships and medication prescribing, and building community health care capacity will be necessary.
Declining incidence rates of distal symmetric polyneuropathy in persons with type 1 and type 2 diabetes in Denmark, with indications of distinct patterns in type 1 diabetes.
Authors: Isik Mizrak Hatice , Hansen Tine Willum , Rossing Peter , Rotbain Curovic Viktor , Vistisen Dorte , Amadid Hanan , Hansen Christian Stevns
Published: August 2023

Objective It is not known if incidence rates for diabetic distal symmetric polyneuropathy (DSPN) are decreasing, as for other diabetic complications. Here, we investigated incidence rates for DSPN in type 1 and type 2 diabetes in a large population-based study.

Research design and Methods In the period 1996 to 2018 19,342 individuals were identified at a Danish tertiary diabetes center. Vibration perception threshold (VPT) was assessed by biothesiometry, repeated throughout the study. Exclusion of prevalent DSPN cases or missing data left 9,473 individuals for analysis of DSPN using a cut-off above 25 V and 2,783 individuals using age-sex-height specific cut-offs. Poisson regression analysis was used to model incidence rates of DSPN for both cut-offs and separately for diabetes types. Covariates were sex, age, diabetes duration and calendar time.

Results Incidence rates of DSPN decreased from 1996 to 2018 e.g., from 4.78 [3.60-6.33] /100 PY to 1.15 [0.91-1.47] /100 PY for 40-year-old men with type 1 diabetes and from 16.54 [11.80-23.18] /100 PY to 8.02 [6.63-9.69] /100 PY for 60-year-old men with type 2 diabetes, when using above 25 V as cut-off.

Analyses using age-sex-height specific cut-off demonstrated similar incidence patterns by calendar time without sex differences. For type 1 diabetes, decreasing incidence rate were seen with higher age.

Conclusion Incidence rates for DSPN are declining in type 1 and type 2 diabetes, possibly due to improved diabetes treatment. This causality remains to be explored. Distinct age-related patterns indicate that the pathophysiology of DSPN may differ between diabetes types.
The relative importance of various environmental exposures to nickel in causing
Authors: Malten KE , Spruit D.
Published: August 2023

No abstract available
Cutaneous reactions to kallikrein, bradykinin and histamine in healthy subjects
Authors: Juhlin L , Michaëlsson G.
Published: August 2023

No abstract available
The biology of psoriasis. An experimental study of the Koebner phenomenon.
Authors: Pedace FJ , Muller SA , Winkelmann RK.
Published: August 2023

No abstract available
Latency and duration of pruritus elicited by trypsin in aged patients with
Authors: Rajka G.
Published: August 2023

No abstract available
Sensitizing capacity of usnic acid derived from lichenized fungi.
Authors: Mitchell JC , Maibach HI
Published: August 2023

No abstract available
Delayed reactivity to bacterial and viral extracts in the aged.
Authors: Rajka G.
Published: August 2023

No abstract available
Proteolytic enzymes in the skin. 3. Studies on the extractability, stability and
Authors: Jansén CT , Hopsu-Havu VK.
Published: August 2023

No abstract available
Effect of ultra-violet light on the texture of the human skin denoting the
Authors: Adams-Ray J.
Published: August 2023

No abstract available
Scanning electron microscopy of psoriatic human epidermis
Authors: Mishima Y.
Published: August 2023

No abstract available
Fluorometry of a DOPA peptide and its thioether
Authors: H Rorsman , AM Rosengren , E. Rosengren
Published: August 2023

No abstract available
Plethysmographic recordings of skin pulses. 3. Effect of corticosteroids, dithranol and tar in psoriasis
Authors: P. Thune
Published: August 2023

No abstract available
Ultraviolet light inflammation and C-reactive protein in a case of agranulocytosis with erysipelas
Authors: CO Kindmark , H Möller , E. Neumann
Published: August 2023

No abstract available
Monilethrix
Authors: G. Wennersten
Published: August 2023

No abstract available
Multiple keratoacanthoma (self-healing squamous epithelioma according to Ferguson-Smith)
Authors: G. Rajka
Published: August 2023

No abstract available
Morphea tuberosa-lichen sclerosus
Authors: L. Juhlin
Published: August 2023

No abstract available
Lichen myxedematosus with generalized nodular panniculitis
Authors: S Lidén , P Westermark , JO Hildén , AM. Ros
Published: August 2023

No abstract available
Hepatitis presenting as transient urticaria
Authors: B Ljunggren , H. Möller
Published: August 2023

No abstract available
Changes in the -fibrous protein during epidermal keratinization
Authors: HP Baden , LA. Goldsmith
Published: August 2023

No abstract available
Localization of wart virus antigen in human plantar warts (verrucae vulgares)
Authors: J. Genner
Published: August 2023

No abstract available
Lentiginosis profusa syndrome (multiple lentigines syndrome). II. Histological findings, modified Crowe's sign, and possible relationship to von Recklinghausen's disease
Authors: VJ. Selmanowitz
Published: August 2023

No abstract available
Studies on the ultrastructure of psoriasis and of the normal" skin of psoriatics"
Authors: C Nagy-Vezekényi , I. Zs-Nagy
Published: August 2023

No abstract available
Widespread acrodermatitis chronica atrophicans in two sisters
Authors: K. Kuokkanen
Published: August 2023

No abstract available
Oral ampicillin in uncomplicated gonorrhoea. IV. Comparison of pharmacological and clinical results
Authors: G. Eriksson
Published: August 2023

No abstract available
Erythropoietic protoporphyria. VI. The synergistic effect of ultraviolet and infrared radiation and protection against these wavelengths
Authors: Runge WJ , Fusaro RM
Published: August 2023

No abstract available
Acute febrile neutrophilic dermatosis (Sweet's syndrome). Report of two cases and review of the literatur
Authors: Holst R. , Mobacken H.
Published: August 2023

No abstract available
Microradiographic and autoradiographic studies of keratin formation in human hair
Authors: Forslind B. , Lindström B. , Swanbeck G.
Published: August 2023

No abstract available
Quantitative microradiography of normal human nail
Authors: Forslind B. , Lindström B. , Philipson B.
Published: August 2023

No abstract available
Plasma fat elimination tissue lipoprotein lipase activity and plasma fatty acid composition during sequential treatment with etretinate and isotretinoin
Authors: Vahlquist C , Lithell H  , Michaëlsson G , Selinus I  , Vahlquist A , Vessby B
Published: August 2023

In an attempt to elucidate the mechanisms underlying retinoid-induced hyperlipidemia, the effects of etretinate (Tigason) and isotretinoin (Roaccutane) on two different plasma fat elimination variables and on the plasma fatty acid composition were studied. Twelve patients with various hyperkeratotic disorders participated in a double-blind cross-over study of etretinate and isotretinoin. Each drug was given for 8 weeks with an 8-week intermission. On five occasions an intravenous fat tolerance test (IVFTT) was performed and the lipoprotein lipase activity (LPLA) in adipose tissue and skeletal muscle was measured. Isotretinoin significantly reduced the fat elimination rate as measured by IVFTT (p less than 0.001) and also decreased the muscle LPLA (p less than 0.05). The etretinate-induced depression of these variables was not statistically significant. The LPLA of adipose tissue and the plasma fatty acid composition were not markedly altered by any of the drugs. The observed changes are probably not sufficient to entirely explain retinoid-induced hyperlipidemia but the results strengthen the opinion that plasma lipid metabolism is more unfavourably affected by isotretinoin than etretinate.
Experience with a gluten free diet in the treatment of linear IgA disease
Authors: Leonard JN , Griffiths CE  , Powles AV , Haffenden GP  , Fry L
Published: August 2023

A study was undertaken to determine whether the skin eruption of linear IgA disease (LAD) was gluten dependent. Six patients with LAD were treated with a gluten free diet (GFD) for an average period of 33 months (range 19-48). Although one patient with LAD had an enteropathy which was clearly gluten sensitive, there was no convincing evidence that the rash of any of the patients responded to a GFD. Four of the six patients showed no significant alteration in their drug requirements. The remaining 2 patients showed a fall in minimum drug requirement but there was no increase after gluten challenge indicating that they were entering spontaneous remission. This contrasts to the situation in dermatitis herpetiformis, where both the rash and the enteropathy are gluten dependent. These data add further to the evidence that LAD and dermatitis herpetiformis are separate entities.