bluuebunny/crossref_metadata_2025 huggingface dataset:
PENINGKATAN KEMAMPUAN MENULIS PUISI BEBAS SISWA KELAS VII SMPN 1 AIR KUMBANG BANYUASIN MELALUI METODE OUTDOOR STUDY
Authors: Suryadi Edi , Ramadhan Ahmad Tarmizi
Published: June 2023

Penelitian ini bertujuan untuk meningkatkan kemampuan menulis puisi bebas siswa kelas VII SMPN 1 Air Kumbang melalui metode Outdoor Study. Jenis penelitian tindakan kelas (PTK). Tahapan pelaksanan mulai dari perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Penelitian siklus I berlangsung pada tanggal 1 - 8 Agustus 2014 dan siklus II tanggal 27 â€“ 30 Agustus 2014. Jumlah siswa sebagai subjek penelitian 31 orang. Data yang dikumpulkan terdiri atas data hasil pengamatan aktivitas siswa dan hasil tes akhir siklus. Indikator keberhasilan penelitian adalah jika 85% siswa telah mampu menulis puisi bebas mencapai KKM â‰¥ 70, kemudian 75% mampu mengikuti aktivitas belajar yang diukur melalui observasi. Hasil penelitian diketahui bahwa hasil belajar siswa pada siklus/tindakan I rata-rataÂ  71,91 dan taraf ketuntasan belajar sebesar 64,52%. Pada siklus/tindakan II memiliki nilai rata-rata 82,87 dan taraf ketuntasan belajar sebesar 93,55%. Dari hasil analisis tersebut disimpulkan bahwa kemampuan menulis puisi bebas siswa kelas VII SMPN 1 Air Kumbang melalui metode Outdoor Study meningkat. Untuk meningkatkan kemampuan menulis puisi bebas dilakukan dengan mengungkapkan perasaan serta pikiran setiap siswa pada aspek penghayatan, pelafalan dan pengintonasian, dan penampilan. Persepsi siswa terhadap penggunaan metode Outdoor Study dalam pembelajaran menulis puisi bebas cukup baik.
SCRIPTED ROLE PLAY-BASED TEACHING TO IMPROVE SPEAKING SKILL OF THE ELEVENTH GRADE STUDENTS OF SMAN 14 PALEMBANG
Authors: Iman Jaya Nur
Published: June 2023

Role play is very prominent in English speaking classroom because it allows the students to have more oral practice in different social contexts and roles. The purpose of this paper was to find out whether or not scripted role play could make a difference in improving studentsâ€™ speaking skill achievement. The population of this research paper was all the eleventh grade students of SMAN 14 Palembang in the academic year of 2009-2010. The students were given intervention for 16 meetings including pre-test and post-test in the form of speaking test. The SOLOM rubric was used to measure studentsâ€™ speaking skill. The findings showed that (1) there was a significant improvement in speaking skill where t obtained of speaking skill was 4.971 (p<0.000), (2) there was also a significant mean difference between the speaking skill of the experimental and control groups where t obtained was 6.804 (p<0.000). Hence, from the research findings, it could be concluded that scripted role play could significantly improve the studentsâ€™ speaking skill achievement in English teaching and learning environment.
IMPROVING LITERACY SKILLS THROUGH WRITING DRILLS OF THE SECOND YEAR STUDENTS OF SMP 1 PALEMBANG
Authors: Anggraini Retika Wista
Published: June 2023

The purpose of this study to find out whether or not writing drills to improve the second year studentsâ€™ literacy skills as observed at SMP Negeri 1 Palembang. The population of this study consisted of eight classes with 156 male students and 154 female students. The population of this study are 320 students of the second year students of SMP Negeri 1 Palembang. The total number of sample was 80 students. A quasi experimental method was used in this study. The data collected by means of a pre-test given to both groups before the treatment and a post-test given after the treatment to both groups. To check whether the application of the instruction could run well as it was designed. the students were evaluated using t-test analysis of statistical product and service solution (SPSS) version 12 to run the analyses and interpreted quantitatively and qualitatively to satisfy the objectives of the study. The result showed that there was a significant acceleration in terms of the studentsâ€™ reading and writing skills, and there was a positive respond towards this instruction. In conclusion, writing drills can improve the second year studentsâ€™ literacy skills. Thus, the proposed instruction for reading and writing skills through writing drills either conceptually or practically is plausible to apply in any subjects, especially in reading and writing classes.Key Words :literacy skills, writing drills
IMPROVING STUDENTSâ€™ WRITING ABILITY OF THE ECONOMIC MANAGEMENT STUDY PROGRAM THROUGH BLOGS AT INDO GLOBAL MANDIRI UNIVERSITY PALEMBANG
Authors: Surayatika Desi
Published: June 2023

The aims of this study were to find out theprogress in studentsâ€™ writing achievement after they were taught by using blogs, and to find out the significant difference in studentsâ€™ writing achievement between the students who were taught by using blogs and those who were not. A quasi-experimental method was used in this study. The population of the study was all the students in Faculty of Economic at Indo Global Mandiri University in the academic year 2014/2015. The sample consisted of 40 students where 20 students for experimental group and 20 students for control group, and was selected by using purposive sampling. In order to get the data, a test was used. The data was obtained in the form of writing test. The test was given twice, to the experimental and control groups, as pre-test and post-test. The result of the test was analyzed by using t-test through SPSS program. The finding showed that (1) There were some progresses in studentsâ€™ writing due to the use of blog during the teaching and learning activities, and (2) There was a significant difference between the students who were taught by using blogs and those who were not.Â Key Words: Improving, Writing Ability, Blogs
The Effectiveness of Tourism Videos to Improve The Tenth Grade Studentsâ€™ Speaking Achievement in SMKN 6 Palembang
Authors: Syebania Bella , Iman Jaya Nur
Published: June 2023

AbstractThis research was aimed to find out whether there was significant improvement on speaking achievement of the tenth grade students of SMKN 6 Palembang after being taught by using the Tourism Videos and to find out whether there was significant mean difference on speaking achievement between the students who were taught by using Tourism Videos and those who were not. This research applied experimental research design. The sample of this research were 31 students of SMKN 6 Palembang and divided into experimental and control groups. The results of this study were calculated by using SPSS. The research finding showed that the mean score of pretest of experimental group was 56,84 improved to 80,32. And the mean difference of posttest between experimental and control group was 2.129 and the mean difference of speaking improvement between the pretest and posttest within the experimental group was 23,484. The research findings revealed that the teaching of speaking improved the studentsâ€™ speaking achievement due to having received the treatment using Tourism Videos. Hence, that there was significant improvement on speaking achievement in the experimental group and there was significant mean difference between the students who were taught by using Tourism Videos and those who were not.Keywords : Improving speaking skill, speaking skill, tourism videoÂ AbstrakPenelitian ini bertujuan untuk mengetahui apakah ada peningkatan yang signifikan terhadap prestasi berbicara siswa kelas X SMKN 6 Palembang setelah diajar dengan menggunakan Video Pariwisata dan untuk mengetahui apakah ada perbedaan rata-rata yang signifikan pada prestasi berbicara antara siswa yang diajarkan dengan menggunakan Video Pariwisata dan mereka yang tidak. Penelitian ini menggunakan desain penelitian eksperimental. Sampel penelitian ini adalah 31 siswa SMKN 6 Palembang dan dibagi menjadi kelompok eksperimen dan kontrol. Hasil penelitian ini dihitung dengan menggunakan SPSS. Temuan penelitian menunjukkan bahwa skor rata-rata pretest dari kelompok eksperimen adalah 56,84 meningkat menjadi 80,32. Dan perbedaan rata-rata posttest antara eksperimental dan kelompok kontrol adalah 2,129 dan perbedaan rata-rata peningkatan berbicara antara pretest dan posttest dalam kelompok eksperimen adalah 23.484. Temuan penelitian mengungkapkan bahwa pengajaran berbicara meningkatkan prestasi berbicara siswa karena telah menerima perlakuan menggunakan Video Pariwisata. Oleh karena itu, bahwa ada peningkatan yang signifikan pada prestasi berbicara dalam kelompok eksperimen dan ada perbedaan rata-rata yang signifikan antara siswa yang diajar dengan menggunakan Video Pariwisata dan mereka yang tidak.Kata kunci: Meningkatkan keterampilan berbicara, keterampilan berbicara, video pariwisata
The Influences of Local Language to Students in Learning English
Authors: Soma Robi
Published: June 2023

AbstractIt is universally believed that learning a foreign language has its own difficulties. This paper discusses some problems which are faced by English as a Foreign Language students in learning English. Those problems can come from the students themselves and it can also come from their environment that have strong influence their success in learning a foreign language, in this case English. Moreover, how studentsâ€™ local language influence them in learning English and how to overcome such an obstruction are also discussed here.Keyword : local languages, English, and foreign language learningÂ AbstrakSecara universal diyakini bahwa mempelajari bahasa asing memiliki kesulitan tersendiri. Makalah ini membahas beberapa masalah yang dihadapi oleh Inggris sebagai siswa Bahasa Asing dalam belajar bahasa Inggris. Masalah-masalah itu bisa berasal dari para siswa itu sendiri dan itu juga bisa berasal dari lingkungan mereka yang memiliki pengaruh kuat terhadap keberhasilan mereka dalam mempelajari bahasa asing, dalam hal ini bahasa Inggris. Selain itu, bagaimana bahasa lokal siswa mempengaruhi mereka dalam belajar bahasa Inggris dan cara mengatasi hambatan semacam itu juga dibahas di sini.Kata kunci : bahasa lokal, bahasa Inggris, dan pembelajaran bahasa asing
Critical Thinking In Elt: How Cooperative Learning Affects The Efl Learnersâ€™ Critical Thinking Aspects
Authors: Iman Jaya Nur , Angraini Nike
Published: June 2023

AbstractThis research attempted to see whether the cooperative leaning was impactful on EFL learnersâ€™ critical thinking aspects. Non-equivalent pretest and posttest control group design of comparison group design was used in this research. The population of the research was all of the undergraduate students of University of Indo Global Mandiri. Forty students were selected as the sample purposively in the experimental group (treatment group) and control group (non-treatment group), respectively. A critical thinking rubric was employed to measure the EFL learnersâ€™ critical thinking(aspects) and critical thinking aspects(total). The research findings revealed that (1) there was a significant improvement on the EFL learnersâ€™ critical thinking(aspects) and critical thinking (total), (2) There was a significant mean difference on the EFL learnersâ€™ critical thinking(aspects) and critical thinking aspects(total), (3) there was a significant contribution of the critical thinking skill (aspects) and critical thinking aspects(total) in which the aspects of framing personal responses and acknowledging other perspectives had the lowest contribution and the aspects of recoqnizing stakeholders and context had the highest contribution. In conclusion statistically the cooperative learning was significantly impactful on the EFL learnersâ€™ critical thinking aspects in English language teaching.Keywords: Cooperative learning, critical thinking aspectsAbstrakÂ Penelitian ini berusaha untuk melihat apakah pembelajaran kooperatif berdampak pada aspek berpikir kritis peserta didik EFL. Penelitian ini menggunakan desain penelitian non-equivalent pretest and posttest control group design of comparison group design. Populasi dari penelitian ini adalah semua mahasiswa sarjana dari Universitas Indo Global Mandiri. Empat puluh siswa dipilih sebagai sampel secara purposif dalam kelompok eksperimen (kelompok perlakuan) dan kelompok kontrol (kelompok non-perlakuan). Rubrik berpikir kritis digunakan untuk mengukur pemikiran kritis (aspek) pembelajar EFL dan aspek berpikir kritis (total). Temuan penelitian mengungkapkan bahwa (1) ada peningkatan yang signifikan pada pemikiran kritis (aspek) peserta didik EFL danÂ  pemikiran kritis (total), (2) Ada perbedaan rata-rata yang signifikan pada pemikiran kritis peserta didik EFL (aspek) dan aspek berpikir kritis (total), (3) ada kontribusi signifikan dari keterampilan berpikir kritis (aspek) dan aspek berpikir kritis (total) di mana aspek membingkai tanggapan pribadi dan mengakui perspektif lain memiliki kontribusi terendah dan aspek dari para pemangku kepentingan dan konteks yang memiliki kontribusi tertinggi. Kesimpulannya secara statistik pembelajaran kooperatif berdampak signifikan pada aspek berpikir kritis peserta didik EFL dalam pengajaran bahasa Inggris.Kata kunci: pembelajaran kooperatif, aspek berpikir kritis
Significant Roles of Childrenâ€™s Literature In Efl
Authors: Novasyari Ressy
Published: June 2023

ABSTRACTThis article describes about the concept of childrenâ€™s literature, the genre and the role of childrenâ€™s literature in teaching English as a foreign language. In Indonesia, English as a foreign language because Indonesian use Bahasa Indonesia for communication.Childrenâ€™s literature is a kind of literary texts such as picture story books, fable, novel, short stories etc in order to make students interested in reading especially for English as a foreign language. Sometimes they feel bored and lazy to learn English because they thinkÂ  that it is aÂ  difficult subject therefore, English teacher in Indonesia usually teaches the students with language combination between Indonesia and English in teaching and learningÂ  pocess in order to make their students understand what they learn. Not only that, teachers always use textbook as material in teaching and learning process without introducingÂ  new material like literature text and usually the use of teacher-centered strategy in classroom without involving students. OneÂ  solutionÂ  for solving this problem is introducing literature in teaching and learning process. Motivating students to learn English Literature is one of the best approach for teacher in teaching of English language skills (reading, writing, speaking and listening) because it can make students enhance their knowledge from story that they read in literary text.Keywords : Childrensâ€™ literature, genre and role of childrenâ€™s literatureABSTRAKArtikel ini akan menjelaskan tentang konsep sastra anak-anak, macam-macam dan peran sastra terhadap anak-anak dalam mengajar bahasa Inggris sebagai bahasa asing.Di Indonesia, Bahasa Inggris sebagai bahasa asing karena orang Indonesia menggunakan bahasa Indonesia untuk berkomunikasi.Sastra anak-anak adalah jenis teks sastra seperti buku cerita bergambar, dongeng, novel, cerita pendek dll supaya siswa tertarik membaca terutama untuk bahasa Inggris sebagai bahasa asing. Terkadang mereka merasa bosan dan malas belajar bahasa Inggris karena mereka pikir itu adalah pelajaran yang sulit oleh karena itu guru pelajaran bahasa Inggris di Indonesia biasanya mengajar siswa dengan menggunakan bahasa campuran antara bahasa Indonesia dan bahsa Inggris di proses belajar mengajar supaya siswa mengerti apa yang mereka pelajari. Tidak hanya itu, guru selalu menggunakan buku paket sebagai bahan ajar di proses belajar mengajar tanpa mengenalkan bahan ajar baru seperti teks sastra dan biasanya menggunakan strategi yang berpusat pada guru tanpa melibatkan siswa. Salah satu solusi untuk mengatasi masalah ini adalah memperkenalkan sastra dalam proses belajar mengajar. Memotivasi siswa untuk belajar Sastra Inggris adalah salah satu pendekatan terbaik untuk guru dalam mengajar keterampilan bahasa Inggris (membaca, menulis, berbicara dan mendengarkan) karena itu dapat membuat siswa meningkatkan pengetahuan mereka dari cerita yang mereka baca dalam teks sastra.Kata kunci : Sastra Anak- anak, macam sastra dan peran sastra anak- anak
Comparison Of The Effectiveness Of Irrigation and Manual Extraction Techniques On The Comfort Level Of Serumen-Impacted Patients Using The Kolcaba Comfort Theory Approach
Authors: Yobel Sosilo
Published: June 2023

A buildup of cerumen, or earwax, in the ear canal is one of the most common problems experienced by patients and, if ignored, can cause hearing loss, irritation, and discomfort. Comfort is an integral part of nursing work as a client's basic needs which is the goal of nursing work. The nursing approach to providing comfort to patients is based on Kolcaba's comfort theory. This theory includes comfort in four contexts of comfort, namely: physical, psychospiritual, sociocultural, and environmental. The purpose of this study was to compare irrigation techniques' effectiveness with manual extraction on the comfort level of cerumen-impacted patients using the Kolcaba comfort theory approach. This research is pre-experimental research with a "two independent samples test" approach. The sample was 40 respondents who had impacted cerumen, divided into 20 respondents who underwent ear irrigation and 20 respondents who underwent manual extraction. Analysis to determine differences in comfort levels after intervention using the Mann-Whitney test. Results & Analysis. The Mann-Whitney test showed P value = 0.000 (P <0.05), and there was a difference in the comfort level between irrigation and manual extraction. The action of ear irrigation further increases the respondent's sense of comfort compared to manual extraction, because irrigation is more effective in removing impacted cerumen characterized by clean ears and clearer hearing, and does not cause pain.
Ecological Studies of Wolves on Isle Royale
Authors: Hoy Sarah , Vucetich John , Peterson Rolf
Published: June 2023

In February 2023, the wolf population was likely composed of 31 wolves. This is a slight increase from last year’s estimate of 28 wolves (Fig. 1). The wolf population includes an East Pack with 11 wolves, a West Pack with five wolves, three groups of at least three wolves each, and several other wolves that are either loners or only loosely affiliated with one of the smaller groups. There is evidence that pups were born into three, possibly four, litters in April 2022. For context, no litters are thought to have been born between 2015 and 2018. However, following the translocation of wolves to Isle Royale between 2018 and 2019, one litter was born in 2019, two litters were born in both 2020 and 2021, and possibly four litters were born in 2022. Thus, the reproductive success of the wolf population has steadily increased over the last five years. The per-capita kill rate, which is an indication of the rate that wolves acquire food, was 0.52 moose per wolf per month. That rate is somewhat lower than last year’s estimate of 0.71, but similar to what is expected given the number of wolves and moose currently on the island. The estimated abundance of moose is 967, which is a 28 percent decline from last year’s estimate of 1,346. Longer-term population trends suggest that the moose population had increased greatly over an eight-year period (2011-2019) but then started to decline rapidly over the last few years. The proportion of the moose population that is newly recruited individuals (i.e., nine-month-old calves in February) was 1.7 percent, which is very low compared to the long-term average. Predation rate was estimated to be 10 percent, which is similar to last year’s estimate and close to the long-term average. While predation and low recruitment were important contributors to the moose decline, starvation also played an important role.
Improving Fun Learning in Science Subjects by Using Monopoly Game Media
Authors: Latief Abdul , Novalia Niki
Published: June 2023

Purpose of the study: To find out the increase in fun learning in science subjects using monopoly game media in class IV SD Negeri 13/1 Muara Bulian. Methodology: This research method is classroom action research. In this study there were three cycles, in one cycle carrying out two meetings. There are four procedures of this study, namely planning, implementation, observation and reflection. Main Findings: The results of this study are that the use of monopoly games can increase fun learning in Science class IV SD Negeri 13/1 Muara Bulian. The monopoly game used in science learning is different from the monopoly game in general, namely giving quizzes in the form of questions from the material students have studied. It makes students relax, students' attention is devoted, enthusiastic, happy, high concentration and safe when learning takes place. Novelty/Originality of this study: Increase knowledge about the use of monopoly game media as a learning medium to increase fun learning.
The Potential of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), Gene Editing Technology, in the Treatment of Coronary Artery Disease: A Systematic Literature Review
Authors: Mayasari Hilda , Winda Nestamer
Published: June 2023

The treatment of CAD depends on the severity of the disease and the individual's risk factors. There are a number of medications that can help to slow the progression of CAD and reduce the risk of complications. The treatments for CAD can have side effects, which can make it difficult for people to adhere to their treatment plan. The treatments for CAD can be expensive, which can make it difficult for people to afford them. This is especially true for people who do not have insurance. This study aimed to conduct a systematic review to explore the potential of CRISPR in CAD management. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the potential of CRISPR in the treatment of coronary artery disease. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. CRISPR has great potential as a future therapeutic modality for coronary artery disease, where this technology is able to control various CAD risk factors and can trigger the formation of new blood vessels to overcome coronary artery blockade. However, this very potential technology still requires ethical concern studies in order to be able to maintain human sustainability.
The Effect of Vitamin D Supplementation in Psoriasis: A Systematic Literature Review
Authors: Ulva Maria , Yenti Sukarida  , Mery Lisa Pratiwi
Published: June 2023

One of the key factors in the development of psoriasis is inflammation. In people with psoriasis, the immune system mistakenly attacks healthy skin cells, causing them to grow too quickly. This leads to the buildup of dead skin cells on the surface of the skin. Vitamin D can help to reduce inflammation by suppressing the production of pro-inflammatory cytokines. This study aimed to conduct a systematic review to explore the potential of vitamin D supplementation in psoriasis. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the potential of vitamin D supplementation in psoriasis. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Vitamin D inhibits the inflammatory process in psoriasis by inhibiting the production of pro-inflammatory cytokines, activating anti-inflammatory, immune cells, and protecting cells from damage caused by inflammation.
A Combination of Thunder-Fire Moxibustion and Shenghua Decoction Enhances Uterine Involution After Cesarean Section and Postpartum Lactation
Authors:   Department of Gynaecology and Obstetrics, Nanjing Liuhe District Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 211599, China, Cao Yanchun , He Yunyun ,   Department of Gynaecology and Obstetrics, Nanjing Liuhe District Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 211599, China
Published: June 2023

This study aimed to analyze the therapeutic effect of thunder-fire moxibustion plus Shenghua Decoction on uterine involution after cesarean section and its influence on lactation. One hundred and twenty parturients with post-cesarean section uterine involution were recruited from our hospital between October 2021 to July 2022. Participants were grouped into A, B, C, and D groups and treated with conventional therapy, Shenghua Decoction, thunder-fire moxibustion, and Shenghua Decoction+thunder-fire moxibustion, respectively. Groups B, C and D, especially group D, had shorter duration of lochia and faster descending speed of uterine fundus height than group A. All the four groups showed decreased uterine cavity volume after treatment, with the lowest volume found in group D. In terms of clinical efficacy, group D also had better treatment outcomes than the other three groups. Furthermore, the breast fullness degree and lactation yield scores were higher in group D than other groups, whilst the four groups were not statistically different in the incidence of adverse reactions. Shorter length of maternal hospital stays, and uterus recovery time were found in group D. In summary, thunder-fire moxibustion plus Shenghua Decoction should be treatment of choice for post-cesarean section uterine involution that can promote maternal breast milk secretion.
Amarogentin Alleviates Osteoarthritis by Regulating Chondrocyte Proliferation and Autophagy
Authors:   Department of Pharmacy, Ningbo No. 6 Hospital, Ningbo, Zhejiang Province, 315100, China, Luo Weiwei , Zhu Dongjie ,   Department of Pharmacy, No. 906 Hospital of Joint Logistic Support Force of PLA, Ningbo, Zhejiang Province, 315100, China, Yang Yang ,   Department of Pharmacy, No. 906 Hospital of Joint Logistic Support Force of PLA, Ningbo, Zhejiang Province, 315100, China, Li Hongxia ,   Department of Pharmacy, No. 906 Hospital of Joint Logistic Support Force of PLA, Ningbo, Zhejiang Province, 315100, China, Jin Jianfeng ,   Department of Pharmacy, Ningbo No. 6 Hospital, Ningbo, Zhejiang Province, 315100, China, Cai Juanjuan ,   Department of Pharmacy, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315100, China
Published: June 2023

Although amarogentin has been shown to play an amelioration role in several disease states, its role in osteoarthritis progression remains unexplored. To this end, we have examined the role of amarogentin in interleukin-1β-treated chondrocytes, a cell model of osteoarthritis. We observed that chondrocyte proliferation was attenuated after interleukin-1β treatment, which was reversed by amarogentin treatment. In addition, the protein expressions for matrix metalloproteinase-3 and matrix metalloproteinase-9 were enhanced, and collagen II was reduced after interleukin-1β treatment, but these changes were reversed by amarogentin treatment, indicating that amarogentin inhibited interleukin-1β-stimulated extracellular matrix degradation. Moreover, amarogentin strengthened interleukin-1β-triggered chondrocyte autophagy by enhancing LC3II/LC3I, Beclin1, and Atg7 levels and reducing the level of P62, a cargo adaptor protein that interacts with autophagic substrates and delivers them to autophagosomes for degradation. Besides, the expressions of p-AMPK/AMPK and SIRT1 proteins were diminished after interleukin-1β treatment, but these effects were restored by amarogentin treatment, illustrating that amarogentin activated the AMPK/SIRT1 pathway. In conclusion, amarogentin alleviates osteoarthritis by regulating chondrocyte proliferation and autophagy through the AMPK/SIRT1 pathway.
Protective Effect of Hispolon on Postoperative Cognitive Dysfunction in a Sevoflurane-Induced HT-22 Cell Model
Authors:   Department of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China, Wang Hua , Ji Yanan ,   Department of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China, Liu Chuanju ,   Department of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China, Gao Jie ,   Department of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China, Hu Junjiao ,   Department of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China
Published: June 2023

Inhalation of the anesthetic sevoflurane leads to neuronal apoptosis, oxidative stress, and cognitive disorders, resulting in post-operative cognitive dysfunction. Hispolon, a natural polyphenol from Phellinus linteus, has been reported to exhibit anticancer, antidiabetic, antioxidant, antiviral, and anti-inflammatory activities. However, its functions in modulating sevoflurane-stimulated neuronal toxicity remain to be examined. To this end, using sevoflurane-treated HT22 cells as a model of postoperative cognitive dysfunction, we have examined the effect of hispolon. Our results show a diminution of the sevoflurane-induced rise in mitochondrial dysfunction, oxidative stress, cell toxicity, and apoptosis in HT22 cells by hispolon. In conclusion, these data suggest that hispolon may be a potential drug for treating postoperative cognitive dysfunction.
Development of HOTS-Based Student Worksheets on Trigonometry material in Improving Problem Solving Ability
Authors: Hidayah Nurul , Asmarani Dewi , Maryono Maryono
Published: June 2023

One of the impacts of the Covid 19 pandemic is that learning is carried out online so that applications have sprung up to help students solve math problems, as a result students' problem-solving skills are reduced. In addition, the Student Worksheets that has been used so far only contains routine questions, not HOTS questions. For this reason, it is necessary to develop HOTS-based worksheets to improve problem solving abilities. The purpose of this study was to describe the process of developing valid, practical and effective HOTS-based worksheets on Trigonometry material in improving problem solving skills for class X SMKN 3 Boyolangu Tulungagung. This research is research and development called Research and Development (R&D) with the ADDIE development model which includes analysis, design, development, implementation, and evaluation. Sampling used purposive sampling method and the 2 classes selected were Class X Electronics Engineering 4 as the experimental class and Class X Automotive Engineering 4 as the control class. Based on the results of the validator, the responses of educators and students, the results of the research in the form of HOTS-based worksheets on Trigonometry for class X developed using the ADDIE development model were declared valid, practical, effective in improving problem solving skills.
Awareness About Mathematical Patterns in MI Muhammadiyah 3 Jogoroto Jombang Students
Authors: Suryowati Eny , Rozak Abd , Rizkiyati Eka Agustina
Published: June 2023

Awareness of patterns in this study is closely related to generalization. This awareness is the condition of someone who can know there is an order in the pattern, can mention the structure of the given pattern and can determine the next pattern. One of the basic skills in learning mathematics is generalization. This research is a descriptive quantitative research that aims to describe awareness of mathematical patterns in grades 4, 5 and 6 of MI Muhammadiyah 3 Jogoroto Jombang. The sample of this research was 89 students in grades 4, 5 and 6 of MI Muhammadiyah 3 Jogoroto Jombang. All students were given questions about number patterns and figure patterns and then conducted interviews. The results showed that students' awareness of number patterns was 80,65% for 4th grade , 95,83% for 5th grade  and 97,06% for 6th grade . Meanwhile, students' awareness of figure patterns was 87,09% for 4th grade, 95,83% for 5th grade and 100% for 6th grade. Based on the results of this study, it can be seen that students in grades 4, 5 and 6 of MI Muhammadiyah 3 Jogoroto Jombang are already able to recognize pattern regularity, can mention the pattern structure and can determine the next pattern, which is limited in number. Students have not been able to determine the number of elements (structures) in the n-th pattern.
Nature-inspired and medicinally relevant short peptides
Authors: Ciulla Maria G. , Civera Monica , Sattin Sara , Kumar Kamal
Published: June 2023

Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered the cycle of creation, application, and destruction of large and short peptides to the benefit of the host organism, organic and medicinal chemists have in their capacity and small steps, made big developments in the field of peptide synthesis as well as in developing them as therapeutics. In comparison to their big counterparts, i.e. proteins, short peptides encompass several advantages, from the ease of synthesis to their physico-chemical properties. However, the real challenge for in vivo application of therapeutic peptides is to overcome their low plasma availability and their fast enzymatic degradation. This review briefly covers the relevant areas of medicinally important short peptides and the recent developments made to turn these peptides into therapeutics. Also presented in this article are important efforts and strategies used to overcome some of the inherent limitations of peptidic molecules and thereby facilitate their progression in the clinical phases towards approved drugs.
Miesten identiteettityö ja affektiivis-diskursiiviset käytännöt työpaikoilla tapahtuvaa terveyden edistämistä tarkastelevassa puheessa
Authors: Hyvönen Henri
Published: June 2023

Tarkastelen artikkelissani miesten identiteettityötä ja affektiivis-diskursiivisia käytäntöjä puheessa, joka käsittelee työpaikoilla tapahtuvaa terveyden edistämistä. Analyysini kohteena on sosioekonomisesti moninainen 17 miehen haastatteluista koostuva aineisto. Analyysi osoittaa terveyden olevan miehille onnellisuusobjekti, jonka saavuttaminen ja ylläpitäminen asemoidaan välttämättömäksi ehdoksi hyvälle työelämälle. Miehet asemoivat itsensä oikeutetuksi työnantajan apuun. Samalla terveyttä edistävät toimet tunnistetaan valtasuhteiksi. Terveystietoisen ja yhteistyökykyisen terveyskansalaisuuden ohella haastateltavat tuottavat mieheyttä, jossa korostuvat työn autonomia ja vastustava suhde työnjohtoon. Epätarkoituksenmukaiseksi tai riittämättömäksi katsottuun terveyden edistämiseen suhtaudutaan vihamielisesti. Mieheys on osa myönteistä itseymmärrystä sekä terveyden edistämiseen mukautuvassa että sitä vastustavassa identiteettityössä.
PREVENTION OF LOSSES IN THE INDUSTRY, NAMELY WHEN USING THERMAL ENERGY IN GAS PROCESSING PLANTS
Authors:   Tashkent State Technical University, Jakhongir, Normuminov , Charoskhon Nodirkhonova ,   Tashkent State Technical University
Published: June 2023

Shortan GCC is the only enterprise designed for deep processing of gas and production of polyethylene in Central Asia. There are 6 devices in SGST workshop: central boiler device, demineralized water preparation and steam condensate collection and cleaning system device, nitrogen and air intake device, technological water cooling device, fuel system and torch farm, construction of a boiler house in the workers town. Despite the increase in power, as a consequence, the performance didn`t decay. During the process, the equipment is used with a margin of safety.
KOLMATAJLANGAN TUPROQLARDA TEMIR ELEMENTINING LITOPEDOGEOKIMYOSI
Authors:   Farg‘ona davlat universiteti, Go‘zalxon, Sotiboldiyeva , Xusnidaxon Abduxakimova ,   Farg‘ona davlat universiteti
Published: June 2023

This article presents the lithopedogeochemical characteristics of iron in irrigated clogged soils. The content of gross iron in irrigated, calmated soils formed on the banks and alluvial cones of the Sokh and Isafairam rivers ranges from 2.31-3.65% and is in the range of the standard for world soils.
O‘ZBEK TILIDAGI RETRONIMLARNING TEMATIKASI
Authors:   O‘zbekiston Milliy universiteti, Sadoqat Xolmonova
Published: June 2023

It is no secret that the development of a language is closely connected with the life of society. Especially now, when science and digital technologies are rapidly developing, the vocabulary of the Uzbek language continues to be enriched with new retronyms, and this situation is reflected in the speech of people in everyday life. The need to study this phenomenon is increasing due to the fact that the vocabulary of native speakers is enriched with new concepts every day, and we are increasingly using retronyms. This article is devoted to the study of retronyms in the Uzbek language. To this day, the topic of retronyms is one of the relatively little-studied areas. The issue of retronyms in the world and Uzbek linguistics is one of the important issues to be comprehensively studied. Therefore, in our article, we tried to reflect on retronyms in the Uzbek language and their subject matter
АНИОН-РАДИКАЛЬНАЯ КОНДЕНСАЦИЯ КЕТИЛА И ДИАНИОНА БЕНЗОФЕНОН-КАЛИЯ С АНИЛИНОМ
Authors:   Самаркандский государственный университет, Тураева Дилбар
Published: June 2023

In the interaction of K-ketyl and the benzophenone dianion with condensation occurs with aniline, leading to the formation of a Schiff base of diphenylmethinaniline. It flows sideways cleavage of the C-C bond of K-ketyl benzophenone to form benzoic acid, as well as the reduction product – benzhydrol
СОПОСТАВИТЕЛЬНЫЙ АНАЛИЗ СУБСТАНТИВНЫХ ФРАЗЕОЛОГИЧЕСКИХ ЕДИНИЦ С КОМПОНЕНТОМ ЗООНИМОМ АНГЛИЙСКОГО И КАРАКАЛПАКСКОГО ЯЗЫКОВ
Authors:   Каракалпакский Государственный университет, Зарима Сагатова
Published: June 2023

In modern scientific literature, a large number of studies are devoted to human observation of animals and the multifunctionality of images of representatives of the animal world. This article analyzes the semantic structure of English and Karakalpak substantive phraseological units with zoonym components. The above analysis showed that the semantic properties of the studied substantive phraseological units have a significant similarity. However, they differ in semantics of the zoonym component, which reflects the mentality of the people.
ГЕНДЕРНЫЙ ДИСБАЛАНС В СФЕРЕ СРЕДНЕГО ОБРАЗОВАНИЯ
Authors:   Белорусский государственный университет физической культуры, Васильевна Синелёва Марина
Published: June 2023

Analysis of official statistical data has shown a significant predominance of women in the teaching staff of general education institutions in the Republic of Belarus. Feminization of the structure of teaching staff makes it relevant to study the economic and social consequences of this phenomenon
ИНТРОДУКЦИЯ СОРТОВ И ГИБРИДОВ НЕТРАДИЦИОННЫХ КУЛЬТУР НА ПРИМЕРЕ ГОРНОЙ БАЗИЛИКИ
Authors:   Самаркандский филиал Ташкентского государственного аграрного университета, Лола Халмирзаева
Published: June 2023

The analysis of carried out investigations on introduction types and hybrids of not usual cultures in mountain basilica sample has been presented. It has been shown that unlike in the open areas cultivation and introduction types and hybrids of mountain basilica in greenhouse conditions of Uzbekistan allows obtain us crop for 3-4 times in season independently of seasons. It has been revealed that the resistivity of mountain basilica to the main pests and diseases is higher than plants cultivated in the open areas.
ИНТРОДУКЦИЯ СОРТОВ СПАРЖИ ДЛЯ КЛИМАТИЧЕСКИХ УСЛОВИЙ УЗБЕКИСТАНА
Authors:   Самаркандский филиал Ташкентского государственного аграрного университета, Лола, Халмирзаева , Севара Хасанова ,   Самаркандский филиал Ташкентского государственного аграрного университета
Published: June 2023

The results of the experiences carried out on introduction of 10 types of asparagus for climatic conditions of Uzbekistan have been presented. It has been shown that practically all asparagus types tolerate easily Uzbekistan climatic conditions. It has been revealed that studied plants develop the best in pots, after in ground in greenhouses and the worst in open fields. The longest length have sickle and racemose types and at the time, the least length has Shprenger asparagus. The favorable conditions for selected plants in winter and autumn are different temperature ranges. For example, if in winter period for asparagus the best temperature range corresponds from 14°С up to 17°С at the same time in autumn it develops normally in range temperatures up to 25°С.
JAMIYATDA BARQAROR SIYOSATNI TA'MINLASH JARAYONIDA MAFKURAVIY TARBIYANING O‘RNI VA AHAMIYATI.
Authors:   Toshkent davlat agrar universiteti, Rominovna Kenjaeva Dilrabo
Published: June 2023

Globalization processes create unexpected problems for humanity along with new opportunities. The globalization of the political-ideological sphere has a great influence on national spirituality. This article analyzes from a philosophical point of view the issue of shaping ideological thinking among young people through the promotion of the national idea, increasing the effectiveness of spiritual and educational work, further developing literature and reading in society, and teaching history in a national spirit.
RADIKAL MAFKURALARNING KO‘RINISHLARI VA JAMIYAT BARQARORLIGIGA TA’SIRI
Authors:   Respublika Ma’naviyat va Ma’rifat markazi huzuridagi Ijtimoiy-ma’naviy tadqiqotlar instituti, qizi Maftuna Namozova Shokir
Published: June 2023

The article provides opinions about radical ideologies that appear in society, manifest themselves and cause instability in society, affecting the world of society and the way of life of people.
ЎЗБЕКИСТОН РЕСПУБЛИКАСИДА ОИЛА ИНСТИТУТИНИ МУСТАҲКАМЛАШ АСОСЛАРИ
Authors:   ТТЕСИ “Ижтимоий фанлар ва жисмоний тарбия”катта ўқитувчиси, Исмаиловна Садикова Роза
Published: June 2023

this article will study the creation of necessary factors for family immunity in the Republic of Uzbekistan on the basis of laws regulating family relations to strengthen the family.
ВОДА КАК ВАЖНЕЙШИЙ ПРИРОДНЫЙ РЕСУРC
Authors:   доцент ТашГАУ,, Раимжанова, У.Н. , Тураев, Ш. ,   студент 21-64 группы
Published: June 2023

This article is devoted to the study of such issues as water security, which is a global condition for the life of mankind. Today, in some places there are territories that are unable to provide not only an abundance of clean water, but also the vital need for clean water. In the conditions of limited and scarce water resources in the Republic of Uzbekistan, the problem of water security is considered as an integral part of national security. Considering the aggravation of water problems in the world and the Central Asian region, as well as the special importance of water resources for the country.
UNIVERSITETLAR VA INTELLEKTUAL MULK: INTELLEKTUAL MULKNI YARATISH SIYOSATINI QANDAY TARTIBGA SOLISH KERAK?
Authors:   Toshkent davlat yuridik universiteti, Bahriddinovich Toshkanov Nurbek
Published: June 2023

This article analysis the role of IP politics, the process of researcher-university- business. It argues although it is set out that National University should be transferred to University, we need to concentrate to moving to University 4.0. In doing this, we can successfully move towards the chain of education-research-commercialisation-social impact.
ABOUT THE SOURCE STUDIES OF THE CITY OF SIGHNOQ
Authors:   Candidate Of Historical Sciences, Associate Professor Department Of History And Ethnology Of The People Of Central Asia Tashkent State University Of Oriental Studies, Uzbekistan, Alimova R.R.
Published: June 2023

This article analyzes the information about Sighnoq, one of the cities located in the middle reaches of the Syrdarya, its geographical location, topography, population, trade and economic relations, its important strategic and trade center and the capital in the medieval sources.
CENSORED DATA MODELING: A NOVEL ANTI-REGRESSION FRAMEWORK
Authors:   Department of Mathematics, Faculty of Mathematics and Natural Sciences, Andalas University, Indonesia, Fera Sarmada
Published: June 2023

Censored data, where the exact value of an observation is not fully observed, poses a challenge in statistical modelling. Traditional regression approaches often fail to adequately handle such data, leading to biased estimates and inaccurate predictions. In this study, we propose a novel anti-regression framework specifically designed for censored data modelling. The framework integrates advanced statistical techniques and incorporates mechanisms to mitigate the impact of censoring. By leveraging the information available from censored observations, our approach provides more reliable estimates and improved predictive performance compared to traditional regression methods. We validate the effectiveness of our framework through extensive simulations and real-world case studies. The results demonstrate the superiority of the proposed anti-regression framework in accurately modelling censored data, highlighting its potential for various applications in fields such as medical research, finance, and engineering. This study contributes to the advancement of statistical modelling techniques for censored data and provides a valuable tool for researchers and practitioners dealing with such data in their analyses.
IMPROVING DIGITAL SIGNATURE VERIFICATION ACCURACY THROUGH SUPPORT VECTOR MACHINE LEARNING: A COMPARATIVE STUDY
Authors:   Department of Electronics and Communication Engineering, Geeta Engineering College, Panipat, India, Kumar Gyanendra
Published: June 2023

Digital signatures are widely used in electronic documents, and their verification is crucial to ensure document authenticity and security. However, digital signature verification can be challenging, especially when dealing with large amounts of data. In this paper, we present a comparative study of three Support Vector Machine (SVM) based methods for improving digital signature verification accuracy. We used a dataset of 10,000 digital signatures and compared the performance of linear SVM, polynomial SVM, and radial basis function (RBF) SVM. Our results showed that all three SVM-based methods improved the accuracy of digital signature verification compared to traditional methods. The RBF SVM method was found to be the most effective method for improving accuracy, with an accuracy of 98%.
THEORETICAL BASIS OF MANAGEMENT OF THE FINANCIAL STABILITY OF THE BANKING SYSTEM
Authors:   Jizzakh Polytechnic Institute Assistant Of The Department Of Economics And Management, Uzbekistan, Gulmira Umirova
Published: June 2023

The continuous development of the banking system in our republic is an objective necessity in the conditions of market relations, which, in turn, requires the improvement of the methodological foundations of the creation of the database necessary for the continuous control of the activity and financial stability of commercial banks and their effective management.
INCREASING INVESTMENT ATTRACTIVENESS IN THE DEVELOPMENT OF THE NATIONAL ECONOMY
Authors:   Assistant Of The Department Of ", Usmanova Vasila ,   Economics And Management",   Jizpi, Uzbekistan
Published: June 2023

In the conditions of economic reforms, it is becoming important to study how to increase the competitiveness of the national economy by assessing the attractiveness and potential of the investment environment, analysing the effect of the rational location of productive forces, carrying out interregional natural-demographic, administrative-economic, regional investment policy, ensuring investment activity.
THE PARADIGM OF THE MEANING OF TERMS RELATED TO MILITARY EQUIPMENT
Authors:   Independent Researcher, National University of Uzbekistan, Kazakova Laylo Madorimovna
Published: June 2023

Although the primary requirements for a term in linguistics are that it expresses only one meaning and be devoid of expressiveness, research has shown that it possesses all the characteristics of language units in the lexical layer. There are hyponymy, synonymy, polysemy, homonymy, and antonymy. If we dwell on the phenomenon of hyponymy, this phenomenon is considered not only for terms pertaining to military equipment but also for all areas of the military field; gender-species relations are manifested plainly in each of them.