bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and social determinants of health features of SARS-CoV-2 infection among Black and Caribbean Hispanic patients with heart failure: The SCAN-MP Study
Authors: Edmiston Jonathan B. , Cohn Elizabeth G. , Teruya Sergio L. , Sabogal Natalia , Massillon Daniel , Muralidhar Varsha , Rodriguez Carlos , Helmke Stephen , Fine Denise , Winburn Morgan , Chiuzan Codruta , Hod Eldad A. , Raiszadeh Farbod , Kurian Damien , Maurer Mathew S. , Ruberg Frederick L.
Published: March 2023

Patients with heart failure (HF) often have multiple chronic conditions and are at increased risk for severe disease and mortality when infected by SARS-CoV-2, the virus that causes COVID-19. Furthermore, disparities in outcomes with COVID-19 have been associated with both racial/ethnic identity but also social determinants of health. Among older, urban-dwelling, minority patients with HF, we sought to characterize medical and non-medical factors associated with SARS-CoV-2 infection. Patients with HF living in Boston and New York City over 60 years of age participating in the Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP) study between 12/1/2019 and 10/15/2021 (n = 180) were tested for nucleocapsid antibodies to SARS-CoV-2 and queried for symptomatic infection with PCR verification. Baseline testing included the Kansas City Cardiomyopathy Questionnaire (KCCQ), assessment of health literacy, biochemical, functional capacity, echocardiography, and a novel survey tool that determined living conditions, perceived risk of infection, and attitudes towards COVID-19 mitigation. The association of infection with prevalent socio-economic conditions was assessed by the area deprivation index (ADI). There were 50 overall cases of SARS-CoV-2 infection (28%) including 40 demonstrating antibodies to SARS-CoV-2 (indicative of prior infection) and 10 positive PCR tests. There was no overlap between these groups. The first documented case from New York City indicated infection prior to January 17, 2020. Among active smokers, none tested positive for prior SARS-CoV-2 infection (0 (0%) vs. 20 (15%), p = 0.004) vs. non-smokers. Cases were more likely to be taking ACE-inhibitors/ARBs compared to non-cases (78% vs 62%, p = 0.04). Over a mean follow-up of 9.6 months, there were 6 total deaths (3.3%) all unrelated to COVID-19. Death and hospitalizations (n = 84) were not associated with incident (PCR tested) or prior (antibody) SARS-CoV-2 infection. There was no difference in age, co-morbidities, living conditions, attitudes toward mitigation, health literacy, or ADI between those with and without infection. SARS-CoV-2 infection was common among older, minority patients with HF living in New York City and Boston, with evidence of infection documented in early January 2020. Health literacy and ADI were not associated with infection, and there was no increased mortality or hospitalizations among those infected with SARS-CoV-2.
RNA sequencing revealed the multi-stage transcriptome transformations during the development of gallbladder cancer associated with chronic inflammation
Authors: Yang Sen , Qin Litao , Wu Pan , Liu Yanbing , Zhang Yanling , Mao Bing , Yan Yiyang , Yan Shuai , Tan Feilong , Yue Xueliang , Liu Hongshan , Xue Huanzhou
Published: March 2023

Gallbladder cancer (GBC) is a highly malignant tumor with extremely poor prognosis. Previous studies have suggested that the carcinogenesis and progression of GBC is a multi-stage and multi-step process, but most of them focused on the genome changes. And a few studies just compared the transcriptome differences between tumor tissues and adjacent noncancerous tissues. The transcriptome changes, relating to every stage of GBC evolution, have rarely been studied. We selected three cases of normal gallbladder, four cases of gallbladder with chronic inflammation induced by gallstones, five cases of early GBC, and five cases of advanced GBC, using next-generation RNA sequencing to reveal the changes in mRNAs and lncRNAs expression during the evolution of GBC. In-depth analysis of the sequencing data indicated that transcriptome changes from normal gallbladder to gallbladder with chronic inflammation were distinctly related to inflammation, lipid metabolism, and sex hormone metabolism; transcriptome changes from gallbladder with chronic inflammation to early GBC were distinctly related to immune activities and connection between cells; and the transcriptome changes from early GBC to advanced GBC were distinctly related to transmembrane transport of substances and migration of cells. Expression profiles of mRNAs and lncRNAs change significantly during the evolution of GBC, in which lipid-based metabolic abnormalities play an important promotive role, inflammation and immune activities play a key role, and membrane proteins are very highlighted molecular changes.
The anti-immune dengue subgenomic flaviviral RNA is present in vesicles in mosquito saliva and is associated with increased infectivity
Authors: Yeh Shih-Chia , Strilets Tania , Tan Wei-Lian , Castillo David , Medkour Hacène , Rey-Cadilhac Félix , Serrato-Pomar Idalba M. , Rachenne Florian , Chowdhury Avisha , Chuo Vanessa , Azar Sasha R. , Singh Moirangthem Kiran , Hamel Rodolphe , Missé Dorothée , Kini R. Manjunatha , Kenney Linda J. , Vasilakis Nikos , Marti-Renom Marc A. , Nir Guy , Pompon Julien , Garcia-Blanco Mariano A.
Published: March 2023

Mosquito transmission of dengue viruses to humans starts with infection of skin resident cells at the biting site. There is great interest in identifying transmission-enhancing factors in mosquito saliva in order to counteract them. Here we report the discovery of high levels of the anti-immune subgenomic flaviviral RNA (sfRNA) in dengue virus 2-infected mosquito saliva. We established that sfRNA is present in saliva using three different methods: northern blot, RT-qPCR and RNA sequencing. We next show that salivary sfRNA is protected in detergent-sensitive compartments, likely extracellular vesicles. In support of this hypothesis, we visualized viral RNAs in vesicles in mosquito saliva and noted a marked enrichment of signal from 3’UTR sequences, which is consistent with the presence of sfRNA. Furthermore, we show that incubation with mosquito saliva containing higher sfRNA levels results in higher virus infectivity in a human hepatoma cell line and human primary dermal fibroblasts. Transfection of 3’UTR RNA prior to DENV2 infection inhibited type I and III interferon induction and signaling, and enhanced viral replication. Therefore, we posit that sfRNA present in salivary extracellular vesicles is delivered to cells at the biting site to inhibit innate immunity and enhance dengue virus transmission.
The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector
Authors: Casas-Sanchez Aitor , Ramaswamy Raghavendran , Perally Samïrah , Haines Lee R. , Rose Clair , Aguilera-Flores Marcela , Portillo Susana , Verbeelen Margot , Hussain Shahid , Smithson Laura , Yunta Cristina , Lehane Michael J. , Vaughan Sue , van den Abbeele Jan , Almeida Igor C. , Boulanger Martin J. , Acosta-Serrano Álvaro
Published: March 2023

Trypanosoma brucei spp. develop into mammalian-infectious metacyclic trypomastigotes inside tsetse salivary glands. Besides acquiring a variant surface glycoprotein (VSG) coat, little is known about the metacyclic expression of invariant surface antigens. Proteomic analyses of saliva from T. brucei-infected tsetse flies identified, in addition to VSG and Brucei Alanine-Rich Protein (BARP) peptides, a family of glycosylphosphatidylinositol (GPI)-anchored surface proteins herein named as Metacyclic Invariant Surface Proteins (MISP) because of its predominant expression on the surface of metacyclic trypomastigotes. The MISP family is encoded by five paralog genes with >80% protein identity, which are exclusively expressed by salivary gland stages of the parasite and peak in metacyclic stage, as shown by confocal microscopy and immuno-high resolution scanning electron microscopy. Crystallographic analysis of a MISP isoform (MISP360) and a high confidence model of BARP revealed a triple helical bundle architecture commonly found in other trypanosome surface proteins. Molecular modelling combined with live fluorescent microscopy suggests that MISP N-termini are potentially extended above the metacyclic VSG coat, and thus could be tested as a transmission-blocking vaccine target. However, vaccination with recombinant MISP360 isoform did not protect mice against a T. brucei infectious tsetse bite. Lastly, both CRISPR-Cas9-driven knock out and RNAi knock down of all MISP paralogues suggest they are not essential for parasite development in the tsetse vector. We suggest MISP may be relevant during trypanosome transmission or establishment in the vertebrate’s skin.
Education and illustration: Methods, models and paradigms
Authors: Fauchon Mireille , Gannon Rachel
Published: March 2023

This editorial offers a review of the events leading up to and during the ‘Education and Illustration: Models, Methods, Paradigms’ Illustration Research conference hosted by Kingston University, London in 2021. Voiced as dialogue between the issue editors, Rachel Gannon and Mireille Fauchon, it is a reflection on the impact of the COVID-19 pandemic on the organization and production of this research event. The extreme circumstances required the organizers to adapt the conference format, unexpectedly effecting customary dynamics. This is discussed with consideration of the socio and geopolitical contextualising backdrop during that poignant historical moment and how this informed the tone and content of the sessions. Reconsidering the model of the academic research event invited more diverse, experimental and innovative presentations. This authors attribute this shift to the event taking place wholly online, a first for the Illustration Research Network, and the decision to accommodate a more formalized student presence. The critical reflection also articulates how experience and insight gained during the landmark Illustration Research event subsequently informed the editorial decisions made for the Journal of Illustration Volume 9 Numbers 1 & 2. The editorial closes with scrutiny of accessibility, inclusion and appropriate modes of communication with regards to the representation of illustration research and what considerations are provoked in terms of validity and rigour in the representation of scholarly knowledge.
Effect of Aging on Platelets in the Individuals of 30 to 60 Years Age Group – A Cross Sectional Study
Authors: P. Jersey Shiny  , M. Padma Geethanjali
Published: March 2023

BACKGROUND

In this study, we wanted to evaluate to find the significant changes in count of platelets which are one of the blood components with advancing age both in males and females of 30 - 60 years’ age group, to study and analyze the count of platelets in three different age groups of males, to study and analyze the count of platelets in three different age groups of females, to compare the count of platelets in between males and females in different age groups.

METHODS

This was a hospital based analytical observational cross-sectional study conducted among patients in the 30-60 years’ age group in the Department of Physiology in collaboration with Department of Pathology and Department of General Medicine at Government Medical College, Srikakulam, Andhra Pradesh, India, after obtaining clearance from institutional ethics committee and written informed consent from the study participants.

RESULTS

Platelet count decreased with increase in age in males from 31-40 years’ age group to 41-50 years’ age group, and count slightly increased with increase in age from 41-50 years’ age group to 51-60 years’ age group in males. But in female’s platelet count increased with increase in age.

CONCLUSIONS

The present study was done in limited specific age groups that is in between 30-60 years. Further large studies should be done in large population different age groups to know the cause of age specific variations in platelets.
Immunological Insight in COVID-19
Authors: Alivia Maitra  , Charul Jha
Published: March 2023

COVID-19, the most infectious pandemic disease arose due to SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and has caused wide health issues globally. As long as the immune system is functioning normally, infections go unnoticed. Therefore, the coronavirus could threaten the immune system in several ways. Without a question, adequate nutrition plays a significant role in preserving health. Significant immunomodulatory effects are produced by micronutrients such as vitamin C, D, and E, zinc, selenite, and probiotics, which are helpful in infectious diseases. Moreover, it has been demonstrated that a few of these nutrients may be useful in the treatment of COVID-19. This review presents a brief overview of the immune system regarding its protection of the body from COVID-19. Immunity can be acquired through the daily staple meals by the use of plenty of minerals, micro-nutrients, and foods rich in vitamins. Indians can exclusively rely on traditional foods as immunity elevators such as spices, citrus fruits, some vegetables, honey etc. Therefore, this review article summarises possible practices of diet and the benefits of minerals, micro-nutrients and vitamins based on relevant literature available in the Pub Med, and Google Scholar. In the instance of COVID-19, it tries to emphasise the significance of nutrition during times of weakened immunity.
A Rare Case of Eosinophilic Cystitis in an Elderly Male Mimicking as Carcinoma Bladder
Authors: Prakash K. Prabhu  , Ravikumar B. R.  , Mukthinath Gugri
Published: March 2023

Eosinophilic cystitis (EC) is a rare inflammatory condition, first described in 1960 by Brown & Palubinskas.[1] Aetiology remains unclear, although it has been associated with bladder wall injury/allergies in most cases. Histopathologic diagnosis includes transmural inflammation of the urinary bladder with eosinophilia.[2] The patient presents with a spectrum of urological symptoms such as urine frequency (67%), dysuria (62%), gross/microscopic hematuria (68%), suprapubic pain (49%) & urinary retention (10%).[3] In this rare case, an elderly male presenting with clinical & radiological features suggestive of Carcinoma (Ca) bladder ended with a diagnosis of eosinophilic cystitis post-biopsy.
Airborne bacterial species in indoor air and association with physical factors
Authors: Madsen Anne Mette , Moslehi-Jenabian Saloomeh , Frankel Mika , White John Kerr , Frederiksen Margit W.
Published: March 2023

The aim of this study is to obtain knowledge about which cultivable bacterial species are present in indoor air in homes, and whether the concentration and diversity of airborne bacteria are associated with different factors. Measurements have been performed for one whole year inside different rooms in five homes and once in 52 homes. Within homes, a room-to-room variation for concentrations of airborne bacteria was found, but an overlap in bacterial species was found across rooms. Eleven species were found very commonly and included: Acinetobacter lowffii, Bacillus megaterium, B. pumilus, Kocuria carniphila, K. palustris, K. rhizophila, Micrococcus flavus, M. luteus, Moraxella osloensis and Paracoccus yeei. The concentrations of Gram-negative bacteria in general and the species P. yeei were significantly associated with the season with the highest concentrations in spring. The concentrations of P. yeei, K. rhizophila and B. pumilus were associated positively with relative humidity (RH), and concentrations of K. rhizophila were associated negatively with temperature and air change rate (ACR). Micrococcus flavus concentrations were associated negatively with ACR. Overall, this study identified species which are commonly present in indoor air in homes, and that the concentrations of some species were associated with the factors: season, ACR and RH.
Tourism of Ukraine as a Type of Business before and during the War
Authors: YASNOLOB Ilona , DEMIANENKO Nataliia , GALYCH Oleksandr , GORB Oleg , YEHOROVA Olena , LIPSKYI Roman , BOROVYK Tetyana , MYKOLENKO Inna , PROTSIUK Nataliia
Published: March 2023

Ukrainian tourism as a type of entrepreneurship before and during the war was analyzed in the article. It has been noted that Ukraine is a hospitable country, endowed with incredible nature, ancient culture and has delicious food. But since February 24, 2022, the country has completely lost inbound tourist traffic, business tourism came to a halt, and local tourism turned into the migration of internally displaced persons.

It has been determined that the longer the war in Ukraine continues, the more Europe suffers from it as well. Accordingly, the slogan “Stand with Ukraine”, which sounds like the call for help, was proposed to be transformed into “to visit and help”.

It has been studied that great opportunities will open up for inbound tourism after the war. At first, routes related to the war and remarkable post-war locations will be relevant. At the same time, the beauty and hospitality of Ukraine will attract tourists. After the victory, Ukraine will be among the top five countries in the world attractive to visit. The sky is open, or at least nominally safe.
Crises and Conflicts on the Way to Sustainable Tourism Development: A Study of Cox’s Bazar, Bangladesh
Authors: BHUIYAN Mohammad Rakib Uddin , BHUIYAN M. Badruzzaman
Published: March 2023

This study aims to measure the sustainable tourism conditions of Cox's Bazar, Bangladesh, concerning various crises and conflicts inflicted upon it in recent times. Recent crisis studies make it imperative that sustainability should set the bedrock of any industry for its longevity. Following Ko's (2005) tourism sustainability conceptual framework, this study uses a mixed-method approach to map the tourism sustainability of Cox's Bazar. Our studies find that the tourism sustainability in Cox's Bazar hit an intermediate level in the tourism sustainability map suggested by Ko (2005), which depicts that tourism sustainability in Cox's Bazar is neither sustainable nor unsustainable. Lack of reliable crisis response mechanism, lethargic attitudes towards safety and security issues, no control over the market and city development, relaxed attitudes towards the environment and littering in the tourist zones, and Rohingya people's engagement with drug, human trafficking, and flesh trade can be the most significant challenges to the long-term tourism sustainability of Cox's Bazar. However, a time-suited coordinated tourism action plan can put the tourism sustainability of Cox's Bazar back on the pedestal.
Rising Customer Loyalty with Beneficial Impact on Service Quality Dimensions during the COVID-19 Pandemic for Tourism in Thailand
Authors: MUSRIHA Musriha , RAPITASARI Diana
Published: March 2023

The tourism industry is one of the fastest and largest growing industries in the economy nowadays. This industry has proven to be full of opportunities and challenges such as opening international borders, widespread internet access, and increased mobility and wealth of citizens in increasingly industrialized countries such as Thailand. The tourism industry can support the economic development of both local and country economic, earnings from foreign and domestic visitors. Especially during the COVID-19 pandemic, the tourism industry is declining. Therefore, some adjustment is required to increase the recovery rate of the tourism industry.  The goal of this study is to assess the influence of service quality (SERVQUAL) dimensions on customer loyalty using customer satisfaction as an intervening variable. Based on SERVQUAL dimension as the independent variable and customer loyalty as the dependent variable also customer satisfaction is the intervening variable. This research was done in 4 stars hotels in Thailand, that struggle during the COVID-19 pandemic. The data used is based on the questionnaire that spread out to 100 respondents of hotel customers from many countries.  The regression and analysis approaches are used in this research because the goal is to determine the indirect influence of SERVQUAL characteristics and customer satisfaction on customer loyalty. The result of the study showed a positive impact to increase the value of the customer and minimizing customer loss, especially during the COVID-19 Pandemic.
Features of Rural Tourism as an Element of Kazakh Culture during the Pandemic Syndrome
Authors: TLEUBAYEVA Aitolkyn , ZHAKUPOV Altynbek , SHOKHAN Roza , NURGAZINA Aizharkyn , KARIPBAYEV Zhanbota , SIYEUBAYEVA Maral , DOSSOVAk Makhabbat
Published: March 2023

The article discusses the prospects for developing rural tourism as one of the tools for shaping the country's image during and after the pandemic period. The tourism sphere of Kazakhstan, in which there were noticeable changes during the pandemic, is analyzed. Areas infected with coronavirus infection were shown on the map. Also, separately studied the data of the tourism sector of the Akmola and Karaganda regions during the pandemic. Marketing and sociological surveys were conducted to find determine residents' opinion of holiday destinations during the pandemic. In the example of neighboring regions of Akmola and Karaganda regions, some tourist objects contributing to the formation of the image and development of rural tourism were highlighted and marked on the map.

The key strengths of rural tourism development for the Republic of Kazakhstan, which can contribute to the sustainable formation of the country's image, are identified and recommended. The article compares the effects of COVID-19 and its impact on tourism development. Thus, the pandemic allows the development of domestic tourism in the country, due to which the population began to choose and give preference to tourist sites and routes within the country.
Marine Tourism-Based Sustainable Community Empowerment Model in the New Normal Era
Authors: ROMBE Elimawaty , ZAHARA Zakiyah , ADAM Rosida P. , SUARDI Suardi , WAHYUNINGSIH Wahyuningsih , TAUFAL Moh.
Published: March 2023

Community-based tourism is an empowerment approach that involves and places the community as an important public in the context of the new sustainable development paradigm. Community-based tourism is an opportunity to mobilize the potential and dynamics of the community, in order to balance the role of large-scale tourism business actors. This study aims to determine the Model of Marine Tourism-Based Sustainable Community Empowerment in the New Normal Era. This research is descriptive and quantitative. The study used a purposive sampling method with 100 samples with a questionnaire to the community in Palu City and Donggala Regency. This data was analyzed using Partial Least Square (PLS). The results showed that the variable of community-based tourism, where the variables of economy, culture, social, political environment had a significant effect on community development. It states that community empowerment refers to how local communities have a great influence socially and in community organizations to improve their living environment.
Determinants of Sustainable Tourism Destinations in Indonesia
Authors: SILABAN Pasaman , ADHITYA Wisnu Rayhan , KHAERUMAN Khaeruman , DACHI Surya Wisada , AFRIANI Joli , AISYAH Siti , SITORUS Sunday Ade
Published: March 2023

The purpose of this study is to investigate the tourism concept variable, tourism services and facilities and infrastructure affect the success variable of developing sustainable tourism destinations through moderating variables of tourist interest to visit. In this study, the independent variable is related to the development of sustainable tourism destinations, the variable is the concept of tourism, tourism services and facilities and infrastructure, while the dependent variable is the success in developing the concept of sustainable tourism, and the moderating variable is the interest of tourists to visit. The research method used in this study is a quantitative descriptive research method using path analysis. In this study the independent variables are related to factors related tothe development of sustainable tourism destinations, such as tourism concept variables, tourism services and facilities and infrastructure, the dependent variable is the success in developing the sustainable tourism concept, with moderating variable (connecting variable) tourist interest to visit, data analysis using AMOS 20, and data taken is data on the number of tourist visits to Indonesia during 2016-2020 years. Partially variable tourism concept, tourism services and infrastructure advice significant effect on the variable successful development of tourist destinations and has a significant effect on the variable of tourist interest in visiting 5 priority tourist destinations in Indonesia, while simultaneously the variable tourism concept, tourism services and infrastructure advice indirectly has a significant effect on the variable successful development of tourist destinationsthrough the interest of tourists to visit 5 priority tourist destinations in Indonesia. Through the results of research that has been stated that the success of developing tourist destinations depends on the concept of tourism, the tourist services and infrastructure offered are in accordance with the needs and desires of tourists, if the concept of tourism, tourism services and facilities and infrastructure offered are appropriate, then tourists will be motivated to continue to visit these tourist attractions.
Sustainable Development Through Effective Project Management: The Petromasila in Yemen
Authors: Al-Zubaidi Razi , Ariffin Mohd Khairol Bin , Ismail Mohd Idris Shah , Ahmad Kamarul Arifin , Raqee Ali , Abdulsamad Akram
Published: March 2023

This study examines the process by which the components of project management influence the sustainable development effectiveness of PetroMasila personnel in Yemen. The quantitative technique was utilized in the current investigation. The online survey was utilized to gather information from 342 workers working in departments involved in project-related activities. The Structural Equation Model (SEM) was used in Smart-PLS Software to analyze the data. This study revealed that project management and its following aspects, including planning management and cost management had a substantial and favorable impact on the oil industry's capacity for sustainable growth. The study model explained 32% of the variance in sustainable development effectiveness. In addition, this paper outlines limitations and further research.
Practical delta check limits for tumour markers in different clinical settings
Authors: Yu Shinae , Shin Kyung-Hwa , Shin Sunghwan , Lee Hyeyoung , Yoo Soo Jin , Jun Kyung Ran , Shin Hangsik , Kim Sollip
Published: March 2023

Objectives

Few studies have reported on delta checks for tumour markers, even though these markers are often evaluated serially. Therefore, this study aimed to establish a practical delta check limit in different clinical settings for five tumour markers: alpha-fetoprotein, cancer antigen 19-9, cancer antigen 125, carcinoembryonic antigen, and prostate-specific antigen.

Methods

Pairs of patients’ results (current and previous) for five tumour markers between 2020 and 2021 were retrospectively collected from three university hospitals. The data were classified into three subgroups, namely: health check-up recipient (subgroup H), outpatient (subgroup O), and inpatient (subgroup I) clinics. The check limits of delta percent change (DPC), absolute DPC (absDPC), and reference change value (RCV) for each test were determined using the development set (the first 18 months, n=179,929) and then validated and simulated by applying the validation set (the last 6 months, n=66,332).

Results

The check limits of DPC and absDPC for most tests varied significantly among the subgroups. Likewise, the proportions of samples requiring further evaluation, calculated by excluding samples with both current and previous results within the reference intervals, were 0.2–2.9% (lower limit of DPC), 0.2–2.7% (upper limit of DPC), 0.3–5.6% (absDPC), and 0.8–35.3% (RCV99.9%). Furthermore, high negative predictive values >0.99 were observed in all subgroups in the in silico simulation.

Conclusions

Using real-world data, we found that DPC was the most appropriate delta-check method for tumour markers. Moreover, Delta-check limits for tumour markers should be applied based on clinical settings.
Sublinearly Morse boundaries from the viewpoint of combinatorics
Authors: Incerti-Medici Merlin , Zalloum Abdul
Published: March 2023

We prove that the sublinearly Morse boundary of

CAT
⁢

(
0
)

{\mathrm{CAT}(0)}

cubulated groups with factor systems continuously injects in the Gromov boundary of a certain hyperbolic graph Γ. We also show that for all

CAT
⁢

(
0
)

{\mathrm{CAT}(0)}

cube complexes, convergence to sublinearly Morse geodesic rays has a simple combinatorial description using the hyperplanes crossed by such sequences. As an application of this combinatorial description, we show that a certain subspace of the Roller boundary continuously surjects on the subspace of the visual boundary consisting of sublinearly Morse geodesic rays.
Approximate reciprocal relationship between two cause-specific hazard ratios in COVID-19 data with mutually exclusive events
Authors: Li Wentian , Cetin Sirin , Ulgen Ayse , Cetin Meryem , Sivgin Hakan , Yang Yaning
Published: March 2023

COVID-19 survival data presents a special situation where not only the time-to-event period is short, but also the two events or outcome types, death and release from hospital, are mutually exclusive, leading to two cause-specific hazard ratios (csHR
d
and csHR
r
). The eventual mortality/release outcome is also analyzed by logistic regression to obtain odds-ratio (OR). We have the following three empirical observations: (1) The magnitude of OR is an upper limit of the csHR
d
: |log(OR)| ≥ |log(csHR
d
)|. This relationship between OR and HR might be understood from the definition of the two quantities; (2) csHR
d
and csHR
r
point in opposite directions: log(csHR
d
) ⋅ log(csHR
r
) < 0; This relation is a direct consequence of the nature of the two events; and (3) there is a tendency for a reciprocal relation between csHR
d
and csHR
r
: csHR
d
∼ 1/csHR
r
. Though an approximate reciprocal trend between the two hazard ratios is in indication that the same factor causing faster death also lead to slow recovery by a similar mechanism, and vice versa, a quantitative relation between csHR
d
and csHR
r
in this context is not obvious. These results may help future analyses of data from COVID-19 or other similar diseases, in particular if the deceased patients are lacking, whereas surviving patients are abundant.
Inverse problem for the Atangana–Baleanu fractional differential equation
Authors: Ruhil Santosh , Malik Muslim
Published: March 2023

In this manuscript, we examine a fractional inverse problem of order

0
<
ρ
<
1

{0<\rho<1}

in a Banach space, including the Atangana–Baleanu fractional derivative in the Caputo sense. We use an overdetermined condition on a mild solution to identify the parameter. The major strategies for determining the outcome are a direct approach using the Volterra integral equation for sufficiently regular data. For less regular data, an optimal control approach uses Euler–Lagrange (EL) equations for the fractional order control problem (FOCP) and a numerical approach for solving FOCP. At last, a numerical example is provided in the support of our results.
Die Nietzsche-Rezeption in der deutsch-jüdischen Presse von 1892 bis 1918
Authors: Irlbacher Simon
Published: March 2023

The Reception of Nietzsche in the German-Jewish Press from 1892 to 1918.The article analyses Nietzsche’s reception in the German-Jewish press from 1892 to 1918 on the basis of the archives of Richard Krummel. Several narratives can be identified, which, divided into three thematic fields – Nietzsche’s biography, “the Jews”, “the Jewry” – run through the German-Jewish Nietzsche reception and are discussed in the following way: after general remarks on the reception, the quoted aphorisms are analyzed. The treatment of Nietzsche’s biography in the German-Jewish press and Nietzsche’s view on the “racial superiority” of “the Jews” are examined. Nietzsche’s distinction between ancient and modern Judaism, his slave morality theorem and the oppositions between Judea and Athens / Rome are also discussed.
Factors affecting household carbohydrate food consumption in Central Java: Before and during the COVID-19 pandemic
Authors: Rahayu Wiwit , Darsono Darsono , Marwanti Sri , Antriyandarti Ernoiz
Published: March 2023

The COVID-19 pandemic has resulted in a change in food demand. In Central Java, during the pandemic (2021), the proportion of expenditure on the grain food group was higher than in 2020; meanwhile, the proportion of the ready-to-eat food group decreased. This study aims to analyze the pattern of food consumption of carbohydrate sources, the influencing factors, and the elasticity of consumption in households in Central Java before and during the COVID-19 pandemic. This study uses data from the National Socio-Economic Survey (Susenas) for 12 districts/cities in Central Java consisting of 9,812 in 2019 and 10,636 households samples in 2021. Data analysis used the Linear Approximation Almost Ideal Demand System (LA-AIDS) method. Results of the study show that the COVID-19 pandemic has caused changes in the household consumption pattern of carbohydrate-source food in Central Java. The proportion of expenditure on rice, wheat flour, shelled corn, cassava, and potatoes has increased. On the other hand, wet corn, instant noodles, and white rice decreased. The price of food sources of carbohydrates and the number of household members positively affect the consumption of food sources of carbohydrates. At the same time, income has a negative effect. There are differences in the effect of the location of the residence on the consumption of food sources of carbohydrates before and during the pandemic. The value of own-price elasticity and income elasticity shows that before the pandemic, rice was a staple good whose consumption was inelastic. Before and during the COVID-19 pandemic, wheat flour, wet-skinned corn, shelled corn, potatoes, white rice, and cassava in the pre-pandemic period was Giffen because the price elasticity was positive, and the income elasticity was negative. Meanwhile, rice during the pandemic, instant noodles before and during the pandemic, and cassava were Veblen goods because their price and income elasticity were positive. Cross elasticity shows that before the pandemic, most of the relationships between food sources of carbohydrates were substitutes, while during the pandemic, most of the relationships between food sources of carbohydrates were complementary.
New soliton solutions of modified (3+1)-D Wazwaz–Benjamin–Bona–Mahony and (2+1)-D cubic Klein–Gordon equations using first integral method
Authors: Javeed Shumaila , Imran Tayyab , Ahmad Hijaz , Tchier Fairouz , Zhao Yun-Hui
Published: March 2023

In this article, first integral method (FIM) is used to acquire the analytical solutions of (3+1)-D Wazwaz–Benjamin–Bona–Mahony and (2+1)-D cubic Klein–Gordon equation. New soliton solutions are obtained, such as solitons, cuspon, and periodic solutions. FIM is a direct method to acquire soliton solutions of nonlinear partial differential equations (PDEs). The proposed technique can be used for solving higher dimensional PDEs. FIM can be implemented to solve integrable and ion-integrable equations.
Experimental Investigation on Performance Characteristics of Dry Centrifugal Clutch with Grooved Friction Liners
Authors: Dhruv Panchal  , Patel Bhavesh , Gohil Hardik
Published: March 2023

The deteriorated condition of friction liners after prolonged use is one of the primary causes of judder in centrifugal clutches. The friction characteristics can be retained by generating specific textures or grooves on the friction liner. An attempt has been made to study the characteristics of centrifugal clutch using grooved friction liners. A test cycle for centrifugal clutch has been developed using a number of engagements as the basis. A vehicle test bench was used for the experiment where the developed test cycle was automated. The performance characteristics of the centrifugal clutch have been recorded and analyzed with normal friction liners and grooved friction liners for 100 test cycles. For this study, the groove area ratio was retained at 0.15, and the grooves were cut at 90°. After completing 100 test cycles, the clutch with a grooved friction liner exhibited better characteristics. After completing 100 test cycles, the surface roughness reduction at the leading section of the grooved friction liner and normal friction liner has been found to be 6.44% and 8.11%, respectively. The thickness reduction at the leading section of the grooved friction liner and normal friction liner has been reported to be 3.73% and 4.98%, respectively. Throughout the run of 100 test cycles, the higher clutch housing temperature has been witnessed in the case of a clutch with a grooved friction liner. At the 100th test cycle, the clutch torque with a grooved friction liner was 15.22% more than the clutch torque with a normal friction liner. Even after prolonged use, the clutch with grooved friction liner exhibited better judder characteristics and also provided higher fuel economy for vehicles.
Ergonomics Study of Rostrum Design
Authors: Jaafar R. , Hafiz Mohamad M. A.
Published: March 2023

Ergonomics design has been demanded and considered the main effective factor in preventing ergonomics hazards for the user for the last several decades. The design of a product should be based on human factors and anthropometry to ensure a good fit between the product and people. It is also to increase comfort and safety. The purpose of this study is to evaluate the element of ergonomics in the rostrum design used in the school in Kulim Kedah, Malaysia. There are four (4) ergonomic dimension criteria that were used to check the fifteen (15) samples of the rostrum. The rostrum dimensions are compared to the ergonomic dimensions range of the workbench for standing operation from the previous study and established guidelines. The results are described in frequencies and percentages. The result shows that 80% of the rostrum meets the ergonomics design criteria. To achieve a 100% ergonomic rostrum, the product designers must be knowledgeable about ergonomic design and aware of its significance for the user.
Exilios y presencias entre Nicaragua y Costa Rica
Authors: Araya German Chacón
Published: March 2023

As a result of 1948 Civil War in Costa Rica, losers and communist militants chose to exile in Nicaragua. Before Sandinist Revolution (1979), many antiSomocists Nicaraguans decided also to exile in Costa Rica. Consequently, we must consider exile as a process of search for power and ideological confrontation.
Mujeres jóvenes jugadoras: Su situación en el uso de los juegos de video
Authors: González-Sancho Roy , Obando Reyes Fernando
Published: March 2023

Research on video games is presented as a current, innovative and constantly developing space. In order to explore video games from a Latin American and gender-based perspective to the discussion, this work focuses on proposing an initial analysis of the situation of young women players who participate in this activity either professionally or casually. This article is based on an exhaustive review of scientific articles and audiovisual productions related to this topic. The results have been divided into four subcategories: exclusion and gender stereotypes; gamer identity; participation of women in e-sports and women competitors in professional and casual teams and reception of the male hegemonic speech. Finally, some reflections and questions are discussed by the researchers, which aim to provide possible study routes in Latin American and local studies of video games.
Jorge Debravo (1938-1967): ¿un poeta muerto en la literatura costarricense?
Authors: Arroyo Carvajal Yordan
Published: March 2023

In this academic article dedicated to the 53 years of physical death of the Turrialbeño poet Jorge Debravo, a literary critical study is presented on the poem “I do not offer you peace, brother man” (1994), which has not been analyzed in any academic document in charge of studying his life and work. This writing is a source worth studying. It carries a Debravian metaphor that has come to life over the years: man as brother or in other words, the request for union of Costa Ricans to work in harmony for peace and social justice. Also attached is an analysis of a recent poem created in dedication to Jorge Debravo: “Brother Jorge”, by Heco (2019), to support the inexhaustible survival of the Debravian figure through his poetry made God and the need to preserve their social criticim ideas over the years.
Consideraciones acerca del concepto de cultura organizacional y los miembros de una organización de educación superior
Authors: Quirós García Elizabeth
Published: March 2023

This paper advocates to determine the concept of organizational culture in a higher education institution located in the great metropolitan area of Costa Rica. In order to achieve the goals proposed, the research was preeminently conducted under a positivist paradigm, working under a non-experimental quantitative method and cross-sectional descriptive study. Moreover, the premise that the organizational culture of a collectivity plays a vital role when proposing, implementing, developing, and consolidating actions and activities, being these academic and outreach cultural and teaching programs.
¿Qué es el estado de la cuestión en un proceso de investigación? (Desde la mirada de estudiantes de licenciatura de la carrera de Sociología de la Universidad Nacional, Costa Rica)
Authors: Pérez Carrillo Yolanda
Published: March 2023

The purpose of this article is to present the results of an academic exercise that was developed for the undergraduate students of the career of Sociology. During their process of preparing the research proposal, they formulated the state of art based on a methodological guide elaborated by the professor. This guide helped them to elaborate the state of art section, so they generated the necessary inputs for a critical analysis of research lines, referred to the authors’ proposals, both in contrast as meeting points, leading to the construction of new knowledge from the critical reflection of previous research. It allows to guide problematizations in diverse research topics with theoretical support. Also, it allows the opening of new lines of research for other professionals to continue investigating.The exercise allowed students, in atheoretical and practical way, to elaborate in a methodical and structured way the section corresponding to the different topics of interest. This contributes to identify lines of investigation, which allowed students to problematize according to their diverse interests.There are many guidelines that refer to the state of art, however the aim of this proposal is to point out some aspects and processes that people who initiate in the research process should consider when they begin with the elaboration of this section.
The marginal house as the imaginary space/nation
Authors: Molina-Espinoza Ileana
Published: March 2023

The concept of nation is indispensable for every individual and people. It is what creates a sense of belonging and cultural and national identity. In hernovel The house on Mango Street, Chicana writer Sandra Cisneros explores the construction of this space through the metaphor of the house. In this text, the protagonist Esperanza Cordero transforms the space of her marginal home into the equivalent of her nation, thus building a kind of imaginary country where she can take root and grow.
Interrupciones violentas: las advertencias victorianas y la fascinación por una sociedad distópica e inorgánica que se convirtió en el antropoceno
Authors: Elizondo-González José Fabián , Chinchilla-Mora Leonardo
Published: March 2023

A pesar de que la Era Victoriana ha sido analizada como un periodo de esclavización, colonialismo y raza  basado en una supremacía autoadjudicada, poca atención se les ha prestado a las implicaciones ecológicas de dicho imperialismo y a las advertencias que trabajos literarios como The Strange Case of Dr. Jekyll and Mr. Hyde de Robert Louis Stevenson. El presente ensayo se suma a la creciente literatura que analiza literatura victoriana retrospectivamente a través de la edad geológica conocida como Antropoceno, ya que, como propone Taylor, "los estudios victorianos en el Antropoceno […] se alinean con el período histórico durante el cual surgió esta era" (574). A partir del análisis de The Strange Case de Stevenson, este ensayo identifica advertencias acerca del cambio hacia la industrialización que  amenazaba el periodo victoriano, y ofrece también posibles implicaciones de dicho cambio. Asimismo, se enfatiza  en la imaginería de la novela como evocadora de una fascinación por el distopianismo, la cual es articulada a través del proceso de autocreación monstruosa de Dr. Jekyll. Por lo tanto, este artículo se divide en tres secciones principales. La primera es una introducción al contexto histórico que tuvo lugar antes de la época victoriana, haciendo  énfasis en la transición de la Inglaterra romántica y pastoral cuando los románticos "no reconocían una separación radical entre el yo y la naturaleza" (Reed 364) a la industrial y utilitaria (Dimmock). La segunda sección trata de ilustraciones y argumentos de comportamientos ecológicamente monstruosos de la época victoriana materializados en The Strange Case of Dr. Jekyll and Mr. Hyde. Por último, la tercera sección aborda cuestiones (a) morales durante dicha época victoriana, las cuales, a su vez, podrían convertirse en advertencias no escuchadas por futuras generaciones.
El enemigo líquido: la construcción discursiva del enemigo político en la campaña presidencial de Costa Rica en 2018
Authors: Ureña-García Óscar
Published: March 2023

Building a solid enemy in the electoral campaign has been a frequent task. However, that construction has evolved towards a more liquid enemy, whichis molded according to the container in which it needs to be located. This paper is an analysis of the discursive construction of the political enemy inCosta Rica's presidential campaign in 2018 and in how the candidate Fabricio Alvarado constructed his adversary.
¿Qué hora es?... La sección de prensa pedagógica en Repertorio Americano. Aproximaciones
Authors: Cascante Gómez Lode Elena , Gónzalez Alvarado Francisco , Mora Ramírez Andrés
Published: March 2023

Repertorio Americano magazine , edited by Joaquín García Monge, is a valuable means of cultural diffusion and also Latin American and Costa Rican political thought. Different problems are discussed and those related to education are numerous either in quality, authors or subjects throughout the life of the magazine. However, its analysis from the perspective of a place for the diffusion of pedagogical ideas has not yet been done. As a result, this article presents an approach to ¿What time is it?... section as a space for formal pedagogical publications that explain different views on Hispanic American thought from the first half of the 20th century.
Revista Tarja: una faena cumplida
Authors: Bruce Beatriz
Published: March 2023

Tarja magazine, published in the north of Argentina between 1955 and 1960, is a good example of a regional literary publications considered the first important cultural and artistic magazine of that region. It is an expression of identity of its time and a milestone in Latin America.