bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Beneficial Aspect and Therapeutic Potential of Cirsimaritin in the
Medicine for the Treatment of Human Health Complications
Authors: Patel Dinesh Kumar
Published: January 2022

Background:

Herbal plants have been used in medicine for the treatment of numerous
human health complications. Plant-derived products, including extract, botanicals, and preparations,
have been used in medicine and other allied health sectors since a very early age and have
been available in the market for several decades. Flavonoids have been a well-known class of phytochemicals
in medicine due to their anti-oxidant, anti-cancer, anti-inflammatory, anti-bacterial and
hepatoprotective potential.

Method:

In order to know the medicinal importance and therapeutic benefit of cirsimaritin in
medicine, in the present investigation, scientific research data have been collected and analyzed
from various literature data sources, including Science Direct, Google, Google Scholar, PubMed,
and Scopus. Detailed pharmacological activities of cirsimaritin have been analyzed to know the biological
potential of cirsimaritin. However, for the standardization of plant material, numerous analytical
techniques have been developed in the scientific field, and analytical data of cirsimaritin
have been collected and analyzed in the present work.

Results:

Cirsimaritin, also called 4',5-dihydroxy-6,7-dimethoxyflavone, is a flavonoidal class phytochemical
found to be present in the medicinal plant. It has been utilised in medicine to address a
wide range of human health issues. Through the analysis of scientific data, it was found that cirsimaritin
has numerous health beneficial aspects due to its vast pharmacological activities. Its medicinal
importance is mainly due to its anti-oxidant, anti-bacterial, and anti-inflammatory activities.
Further data analysis revealed the therapeutic effectiveness of cirsimaritin on breast cancer, gallbladder
carcinoma, central nervous system disorders, diabetes mellitus, melanogenesis, immune responses,
human erythrocytes, and respiratory burst. The importance of GC-MS, LC-MS, HSSPME,
FTIR, ICP-OES, MS, NMR, LC/ESI-MS/MS, HPLC, reversed-phase HPLC, and TLC techniques
for the analysis of cirsimaritin has been revealed.

Conclusion:

The biological importance of cirsimaritin for the treatment of human health complications
was revealed; it could also be used for the development of effective medicine against human
disorders.
Gallium Components-Based Drug Delivery: A Potential Treatment for
COVID-19
Authors: Torabi Sara , Bahreini Farbod , Rezaei Nima
Published: January 2022

With severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showing new characteristics
and manifesting new variants, the efficacy of vaccination can be reduced. In the meanwhile,
no SARS-CoV-2-specific drug has been introduced in the fight against coronavirus disease 2019
(COVID-19) yet, and currently used drugs have also shown serious side effects in patients under
treatment. Thus, it is pivotal to continue researching potential therapeutics to treat COVID-19. Recently,
studies have shown that Gallium maltolate disrupts the replication of SARS-CoV-2 and therefore
has antiviral activity against this virus. Nevertheless, as Gallium compounds have manifested
serious side effects in the human body (e.g., hemoglobin synthesis dysfunction and pulmonary complications),
drug delivery methods should be recruited to minimize the possible side effects and to optimize
the efficacy of the drug in the fight against COVID-19. Liposomes, as nanocarriers, not only
increase the half-life of the conjugated compound but also have shown promising features in the delivery
of COVID-19-specific drugs to the target tissue. Herein, we propose that conjugation of Gallium
maltolate with liposome nanocarriers can be beneficial to target tissues infected with SARS-CoV-2.
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats
Authors: El Kattawy Hany A. , Abozaid Eman R. , Abdullah Doaa M.
Published: January 2022

Background:

The potential to reproduce declines with age. Late-onset hypogonadism is characterized by reduced serum testosterone. Humanin is a mitochondrial-derived signaling peptide encoded by short open reading frames within the mitochondrial genome. It may protect against some age-related diseases such as atherosclerosis by its cytoprotective effects.

Objective:

The study aimed to investigate the potential anti-aging effects of humanin on the testicular architecture, oxidative stress, some apoptotic and inflammatory markers in the hypogonadal aged male rats.

Methods:

Forty male albino rats were divided into 4 groups: normal adult controls, aged vehicle- treated group, aged testosterone-treated group, and aged humanin-treated group. Twenty-month- old male rats with declined serum testosterone were selected to be the animal models of lateonset hypogonadism. Testicular weights, serum testosterone, and some sperm parameters were measured. Testicular tissue IL-6 and TNF-α, superoxide dismutase activity, glutathione peroxidase, and malondialdehyde were assessed. The activity of caspase-3, BCL2, PCNA, and the nuclear factor erythroid 2-related factor 2-antioxidant response element pathway were evaluated. Testes were subjected to histopathological and immunohistochemical examination. Statistical analysis was executed using One Way Analysis of variance (ANOVA) followed by Post hoc (LSD) test to compare means among all studied groups.

Result:

Humanin treatment significantly improved serum testosterone, sperm characteristics, and antioxidant defenses. It decreased active caspase-3, pro-apoptotic BAX expression, and increased antiapoptotic BCL2 and proliferating cell nuclear antigen (PCNA) possibly via activating the (Nrf2- ARE) pathway.

Conclusion:

Humanin might be a promising therapeutic modality in late-onset hypogonadism as it ameliorated some age-related testicular and hormonal adverse effects.
Evaluation of the Effect of Isobutyl Paraben and 2-ethyl Hexyl Paraben on
P-glycoprotein Functional Expression in Rats: A Pharmacokinetic Study
Authors: Alshogran Osama Y. , Ghraiybah Nour F. Al , I. Al-Azzam Sayer
Published: January 2022

Background:

Pharmaceutical excipients have been shown to influence drug disposition
through modulating transport protein.

Objectives:

This study assessed the effect of single dose administration of parabens on the pharmacokinetics
(PK) of digoxin, a probe substrate of p-glycoprotein (p-gp), in vivo. Also, the effect of
multiple dosing of parabens on p-gp expression was examined.

Methods:

Rats were randomized into four groups that received either the vehicle, 25 mg/ kg verapamil,
100 mg/ kg isobutyl paraben, or 100 mg/ kg 2-ethyl hexyl paraben, which was followed by
giving 0.2 mg/ kg digoxin via oral gavage. Blood samples were collected at different time points,
digoxin concentration was measured using LC/MS-MS, and digoxin PK parameters were estimated.
Another set of rats received multiple doses of parabens for 14 days, followed by measuring intestinal
and hepatic mRNA expression of p-gp using qRT-PCR.

Results:

Single dose administration of verapamil significantly increased Cmax (by 60.4 %) and
AUC0-t (by 61.7 %) of digoxin compared to the control group, while the PK parameters of digoxin
in rats exposed to parabens were not significantly different from the control. Consistently, the mRNA
expression of p-gp in the intestine and liver was not affected by parabens treatment.

Conclusions:

The lack of isobutylparaben and 2-ethylhexyl paraben effect on p-gp may suggest
the insignificant interaction of parabens with p-gp drug substrates, which could be considered for
safety when designing pharmaceutical formulations.
Chemical Constituents ofClusia nemorosaFruits and Evaluation of Antioxidant and Antimicrobial Activity
Authors: Ferreira Rafaela Oliveira , Galo Jéssica Colodette , Lopes Paula Monteiro , Moreno Daniela Sales Alviano , da Silva Tania Maria Sarmento , de Carvalho Mário Geraldo
Published: January 2022

Background:

Clusia nemorosa, popularly known as pororoca, is used in folk medicine to treat inflammation.

Objective:

The current study was conducted to isolate and identify bioactive compounds from C. nemorosa fruits and to investigate their antimicrobial and antioxidant activities.

Method:

The isolation and structural elucidation of the substances were carried out by usual chromatographic techniques and spectroscopic methods, respectively. The antioxidant activity of extracts of C. nemorosa fruits was measured by DPPH assay and antimicrobial activity was evaluated against the microorganisms Staphylococcus aureus, Candida albicans, Cryptococcus neoformans, and Rhizopus oryzae.

Results:

The chemical investigation of the fruit extract of C. nemorosa led to the identification of two phenolic acids, protocatechuic acid (1) and coumaric acid (6), a flavonoid apigenin (7), glycosyl-β- sitosterol (4), glycosyl-stigmasterol (5), citric acid (3), and the trimethyl citrate ester (2). The fraction in AcOET showed the best scavenging activity of the DPPH radical, with IC50 = 23.50±1.7 μg. mL-1. The extracts were inactive against the tested microorganisms up to 2500 μg. mL-1.

Conclusion:

With the exception of the steroid glycosyl-β-sitosterol, the substances are described for the first time in the species, and, in addition, we report the promising free radical scavenging activity showing its potential in the treatment of diseases related to oxidative stress.
Microwave-assisted, [Bmim]HSO4-catalyzed the Friedländer Quinoline
Synthesis of Quinoline Under Solvent-free Conditions
Authors: Duc Dau Xuan , Dung Vo Cong
Published: January 2022

Abstact:

An efficient and green method for the Friedländer quinoline synthesis has been described.
The synthesis was performed under microwave irradiation using ionic liquid [Bmim]HSO4
as a catalyst. A diverse range of quinoline derivatives was obtained in high yields from 2-aminoaryl
aldehydes and ketones under solvent-free conditions.
Denoising and Restoring of Infrared Image of Power Equipment Based on
l2-relaxed l0 Sparse Analysis Priors
Authors: Chen Xuejun , Ma Lin , Zhuang Jianhuang
Published: January 2022

Background:

The infrared image of electrical equipment often contains snow or is
blurred, which makes it difficult to detect and analyze its state.

Methods:

A prior infrared image denoising and restoring method based on L2-relaxation L0 analysis
is proposed. Through the prior image estimation, the problem of image de-blurring and denoising
is transformed into the problem of solving the maximum entropy of a posteriori probability, and
then the parameters are jointly optimized to widely degrade the image, so that the image is locally
sparse from the strip and edge to the linear predictable texture, and the target object to be extracted
is obtained by using the alternative iterative solution, to achieve the purpose of denoising and restoring
of the original fuzzy infrared image with noise. Two kinds of infrared images with different
brightness levels in a 220kV booster station are used for the experiments.

Results:

Compared with BM3D, TwIST, TVL1C, TVL2C, the experimental results show that the denoising
and restoration effect of the proposed method is clearly better than the four methods. The PSNR,
ISNR, and SSIM of the proposed method are greater than the others, and the calculation time is shorter.

Conclusion:

This method can not only enhance the sparsity of the infrared image target and improve
the estimation accuracy, but also has the advantages of minimum image distortion, fast convergence
speed, and preserving the target detail edge. This method can provide a new idea for other
types of infrared image denoising and restoration.
ULOGA RUSKE PRAVOSLAVNE CRKVE U SPREČAVANjU MEĐUNARODNE AFIRMACIJE (PROJEKTA) NEZAVISNOSTI KOSOVA I METOHIJE DO 2008. GODINE
Authors: Ljubicic Radojko
Published: January 2022

Istraživanjima političkih stavova verskih organizacija nije pridat dovoljan značaj u političkim naukama, srazmerno realnom uticaju na političke procese. Studije slučaja ove vrste pomažu nam da otkrijemo kako se obrazuju političke i društvene pozicije, stavovi, vrednosti i kriterijumi religioznih organizacija, koji moraju biti u skladu sa teološkim normama, ali se postepeno i fokus tematike pomera ka aktuelnim problemima. Za rešavanje statusa Kosova i Metohije ključna činjenica je veto Ruske Federacije u SB OUN koji sprečava prijem KiM-a u zajednicu suverenih država OUN, a iza tog veta stoji, između ostalog, principijelna i dosledna pozicija Ruske pravoslavne crkve. Državno-crkveni uticaji su dvosmerni, ali sfera kanona (u Pravoslavlju) je izvan opsega adaptacije vremenu, što izaziva različite reakcije. Izvedena je kratka analiza zvaničnog Crkvenog strateškog dokumenta: “Osnov društvene koncepcije Ruske pravoslavne crkve“. Uzet je u obzir kulturološko-civilizacijski pristup razumevanju motiva i uzroka događaja, pitanje očuvanja kulturne baštine od svetskog značaja, itd. Korišćeni su pojmovi, kategorije, termini, definicije političkih nauka i bogoslovije (teologije). Ruska pravoslavna crkva se trenutno svrstava među najmoćnije organizacije sveta (prema različitim kriterijumima), a njen stav prema statusu Kosova i Metohije je veoma stabilan.
EPISTEMIČKE ZAJEDNICE U OBLASTI KONTROLE NUKLEARNOG NAORUŽANJA KAO SUBJEKTI BEZBEDNOSTI
Authors: Curcic Sladjana
Published: January 2022

Rad se bavi primenom koncepta epistemičkih zajednica u oblasti bezbednosti, sa ciljem da se identifikuju epistemičke zajednice u domenu kontrole nuklearnog naoružanja, ukaže na praktične implikacije njihovog delovanja, ali istovremeno ispita i analitička vrednost koncepta. Na temelju pragmatičnog konstruktivizma, kao teorijskog okvira rada, ukazuje se na delatni potencijal epistemičkih zajednica, kao aktera bezbednosti, kao i na njihovu transformativnu ulogu, kao generatora promena na praktično-političkoj ravni. Posmatrano šire, iz vizure sveobuhvatnog pristupa bezbednosti, širenje dijapazona bezbednosnih problema, njihovo usložnjavanje i prožimanje, podrazumeva aktivnu ulogu novih i sve brojnijih aktera, odnosno subjekata bezbednosti, ali i umnožavanje objekata zaštite, te se epistemičke zajednice, kao sinteza organizacija civilnog društva, naučnih instituta, nezavisnih eksperata, predstavnika univerziteta i akademske zajednice, mogu posmatrati i kao specifični subjekti bezbednosti. Autorka zaključuje da, po ugledu na uspešan primer kontrole nuklearnog naoružanja, baveći se i drugim bezbednosnim problemima, epistemičke zajednice mogu razvijati i unapređivati bezbednosne politike i prakse. Stoga se u teorijskom smislu, relevantnost istraživanja ogleda u tematizaciji bezbednosnih epistemičkih zajednica, kroz specifičnu primenu koncepta na oblast kontrole nuklearnog naoružanja, čime se ujedno podstiče dalja razrada koncepta, naročito u oblasti bezbednosti.
New inequalities for strongly exponentially generalized functions with applications
Authors: Kashuri Artion , Liko Rozana
Published: January 2022

The aim of this paper is to introduce a new class of functions called strongly exponentially generalized (m, ν1, ν2, g1, g2). Some new integral inequalities of trapezium-type for strongly exponentially generalized (m, ν1, ν2, g1, g2) functions with modulus c via Riemann-Liouville fractional integral are established. Also, some new estimates with respect to trapezium-type integral inequalities for strongly exponentially generalized (m, ν1, ν2, g1, g2) functions with modulus c via general fractional integrals are obtained. We show that the strongly exponentially generalized (m, ν1, ν2, g1, g2) functions with modulus c includes several other classes of functions. At the end, some new error estimates for trapezoidal quadrature formula are provided as well. This results may stimulate further research in different areas of pure and applied sciences.
(Completely) weak simple semigroups and (Completely) weak 0-simple semigroups
Authors: Nouri Leila , Mohammadzadeh Saany Hossein
Published: January 2022

The structure theorems for (Completely) simple semigroups and (Completely) 0-simple semigroups have proved a powerful tool in the investigation of such semigroups. In this paper, first of all, we define weak simple semigroups and weak 0-simple semigroups and compare them with simple semigroups and 0-simple semigroups respectively. Then we give examples of these semigroups and describe the structure of them. Also, we define completely weak simple semigroup and completely weak 0-simple semigroup. Finally, by using Green’s equivalences, we prove some results and give equivalences, for these semigroups.
Review on Stability and Power Quality Problem and Mitigation on Renewable Energy Penetration in Grid System
Authors: Roy Anupam Kumar
Published: January 2022

Abstract: An increase in the production and integration of renewable energy sources to the power grid system have begun to have an impact on the stability and security of the power grid. As renewable energy sources (RESs) like solar PV array plant and wind plant begin to displace traditional power plants, grid integration requirements have become an important issue. To ensure grid stability, additional criteria and technological constraints have been implemented. An updated assessment of current integration criteria and compliance control techniques for renewable power plant integration into the electric grid is being conducted as part of this study to close the knowledge gap. There is a comparison of the most important criterion for grid stability, including frequency stability and voltage stability, quality of power, voltage ride-through (VRT), reactive and active power controls. To meet these standards, a variety of control techniques have recently been proposed. As a result, cutting-edge options for compliance technologies and control techniques are analysed and evaluated in this paper. Additionally, a thorough examination of the benefits, challenges, and drawbacks of global harmonisation of integration requirements is included. Even though current incorporation necessities may enhance grid security, stability, operation, and dependability, a thorough assessment concludes that further improvements to shielding legislation, optimization of control system and international harmonisation are still required. There are a number of recommendations for further research into the integration and technical limitations of RESs that follow this. This study's findings could help to create a seamless and stable grid integration of RESs, as well as aid researchers in the development of new design methods and control systems based on current requirements. Educate and support operators in power system for creating or cultivating their individual standards that differ from the international norms that remain in place. Keywords: fault ride-through, Current limitation, grid forming control, grid connection, voltage-source converter
NANO-CARRIER BASED DRUG DELIVERY SYSTEMS CONTAINING BIOACTIVE FROM CARICA PAPAYA FOR ANTI-DIABETIC ACTIVITY
Authors: Patil Rima Ramesh
Published: January 2022

Significant progress has been achieved in the creation of novel drug delivery systems based on herbal bioactive in recent years. Herbal formulations for novel drug delivery systems are more efficient and have more benefits than other alternatives. Papaya (Carica papaya Linn) is very popular for its nutritious as well as therapeutic benefits all over the world. Carica papaya is a tropical and subtropical fruit that is used as a vegetable and in herbal medicine to treat a variety of ailments. The rising prevalence of diabetes, along with the harsh side effects of some synthetic drugs, has prompted an increase in the search for natural alternatives. Liposomes, phytosomes, ethosomes microspheres, nano-capsules, transferosomes, polymeric nanoparticles, nano-emulsions, and nano-emulsions have all been developed using bioactive and plant extracts. The primary motivation for the advancement of alternative drug delivery is to improve drug delivery quality and safety while also providing greater patient comfort.
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW BENZTHIAZOLE OXIME ETHER DERIVATIVES
Authors: Patil Sachin V
Published: January 2022

Some new oxime ether derivatives containing benzthiazole heterocyclic nuclei are synthesized. The reaction of 2-mercapto benzthiazole with α-halo ketones followed by reaction with hydroxylamine gave oxime derivatives which on reaction with alkyl halides viz. ethyl chloride, n-propyl chloride, and n-butyl chloride in absolute ethanol afforded the target compounds 4a-l. The structure of all the synthesized compounds was confirmed by spectroscopic methods like mass and NMR. All compounds after structural confirmation were tested for biological activities.
PREPARATION AND CHARACTERIZATION OF EGG SHELL BHASMA BY USING MODERN ANALYTICAL TECHNIQUES
Authors: Patil Kundan
Published: January 2022

Calcium is one of the essential elements for living beings. As a supplement, it is used to treat Calcium deficiencies due to a calcium deficient diet. In Rasaratnasamuchchaya Calcium bhasma (Eggshell bhasma) is included as a rich calcium supplement. There is a need for work on the determination of the percentage of Calcium in the eggshell and its limit of acceptance. Easy absorption of bhasma in the body is possible when its preparation is carried out in an acidic medium. Lemon juice is one of the acidic mediums employed for this purpose at pH 2.4. The eggshell powder is subjected to five calcination cycles to convert it into the Bhasma. Analysis of Eggshell Bhasma has been done by various modern analytical techniques to determine its exact chemical compositions. Various instrumental methods like XRD, FTIR, and SEM have been incorporated for analysis of raw materials, intermediates as well as final products. The calcium carbonate present in eggshells is in calcite form. In the present work, structural and chemical characterization of eggshell bhasma was carried out to develop an analytical profile of it.
Paso de cordilleranos en el alto andino de Putaendo en perspectiva de ruta patrimonial
Authors: Gajardo Vistoso Gonzalo Osvaldo
Published: January 2022

La cordillera de Putaendo, es un territorio de montaña escenario de una nutrida Ruta Cultural en la que ensamblan diversos elementos Históricos – principalmente el paso del Ejército de Los Andes en 1817 – naturales, culturales y formas de vida trashumante ricas en tradición y folclore, que testimonian siglos de domesticación y humanización del alto andino.
El artículo, destaca los principales elementos Históricos y culturales sincrónicos, inscritos en la Geografía cordillerana de Putaendo, a objeto de aportar claves interpretativas  para una futura declaratoria como Monumento Histórico Nacional y reconocimiento como Ruta Patrimonial con valor universal, en pro de su conservación, protección y puesta en valor
La balanza de la justicia: las lecciones jurídicas shakespearianas en Medida por medida
Authors: Jocelyn-Holt Correa Emilia
Published: January 2022

El siguiente artículo analiza Medida por Medida, una de las obras jurídicas de Shakespeare. Se propone que en ella el bardo nos presenta un caso difícil y un acabado estudio de tres posibles concepciones del derecho y la justicia, y la repercusión práctica que estas discusiones teóricas tienen en los individuos. Estas opciones están representadas en Ángelo, el supuesto ángel; la salida teatral del Duque; y Escalus, cuyo nombre nos recuerda la balanza de la justicia. A través de Ángelo vemos la aplicación estricta de la ley y la negación del rol judicial. En el caso del Duque se ilustra el exceso de misericordia que conlleva una negación del derecho y una apuesta por el teatro. La salida para Shakespeare se encontraría en Escalus, la balanza entre la letra de la ley y el espíritu del derecho, un respeto a la ley a la vez que una consideración de las circunstancias que llevan a aplicar equidad dentro del derecho.
Comparison Of Sagittal Condylar Angle Obtained Using Cone Beam Computed Tomography And Interocclusal Record Materials- An In Vivo Study
Authors: Bahadursingh Ailsinghani Sneha , Vikhe Deepak , Palekar Umesh , Saraf Veena , Hajira Neha , Madanshetty Pallavi
Published: January 2022

: The sagittal condylar guidance angle (SCCA) is calculated by the condyle and articular disc traversing the contour of the glenoid fossa and the articular eminence. The condylar path is controlled by the shape of the fossa, the attachments of the ligaments, the biting load during movement (muscular influence), and the amount of protrusion. The SCGA on an articulator is determined using protrusive records of the patient. Intraoral registrations may compromise accuracy because of dimensional instability of registration materials and it becomes difficult for the dentist to select an appropriate material. The use of cone beam computed tomography (CBCT) has recently become much more common, and when measuring the SCGA using CBCT, more reliable results can be expected. This study was designed to compare the SCGA obtained using CBCT and protrusive interocclusal record made using polyvinyl siloxane and aluwax. Thirty dentulous subjects were selected. SCGA was calculated using CBCT scans for each subject. Intraoral protrusive records were made using polyvinyl siloxane and aluwax bite registration materials at 6mm of protrusion. Records were used to program the articulator and variation in the SCCA was noted. No significant difference was observed between right and left mean values of SCGA in CBCT, polyvinyl siloxane and aluwax. Positive correlation was found between all the three groups; however, significant difference was found in the mean values of SCGA between CBCT and polyvinyl siloxane, CBCT and aluwax (P=0.0001). No significant difference was found in the mean values of SCGA between polyvinyl siloxane and aluwax (P=0.9254). CBCT gave higher mean SCGA values than those obtained using polyvinyl siloxane and aluwax on semi-adjustable articulator in dentulous subjects; whereas mean SCGA values were comparable between polyvinyl siloxane and aluwax. The right and left SCGA values were comparable in each method.
Analisis ekspor kayu manis Indonesia ke Amerika Serikat
Authors: Asrini Yulmi Nur , Hodijah Siti , Nurhayani Nurhayani
Published: January 2022

This study analyzes Indonesian cinnamon export volume to the United States, export cinnamon prices, exchange rates, and domestic cinnamon production. In addition, to investigate the effect of export cinnamon prices, exchange rates, and domestic cinnamon production on Indonesian cinnamon exports to the United States in 2000-2017. The data used was obtained from the official website of the Indonesian Central Statistics Agency, United Nations Commodity Trade (COMTRADE), and the Plantation Service. The data analysis method used in this research is descriptive and quantitative analysis method with multiple linear regression analysis. Based on the multiple linear regression analysis results, it can be concluded that simultaneously export cinnamon prices, exchange rates, and domestic cinnamon production have a significant effect on Indonesian cinnamon exports to the United States. The exchange rate and domestic cinnamon production have a considerable impact, but the price of export cinnamon had no significant effect on Indonesia's cinnamon exports to the United States.

Keywords: Export cinnamon, Price, Exchange rate, Production.
Analisis determinan keputusan nasabah menabung pada Bank Pembangunan Daerah Jambi (Studi kasus pegawai negeri sipil Kota Jambi)
Authors: Lilia Sari Putri Justia , Heriberta Heriberta , Emilia Emilia
Published: January 2022

This study aims to determine the characteristics of Jambi Regional Development Bank customers and to analyze the determinants of customer decisions to save at the Jambi Regional Development Bank, a case study of civil servants in Jambi City. This study uses data collection techniques through questionnaires distributed online, with a sampling technique that is simple random sampling with quantitative descriptive research methods and analyzed using binary logistic regression models through the SPSS program. The sample is Jambi city civil servants as many as 99 respondents. This study indicates that the variables of income and education have no positive and significant effect on the customer's decision to save. While the civil servant class variables were divided into two using a dummy variable namely, civil servant class III had no significant effect. In contrast, class IV civil servant had a positive and significant impact on customer saving decisions. And the age variable has a positive and significant impact, and the number of family dependents has a negative and significant effect on the customer's decision to save.
 Keywords: Customer decision, Age, Number of dependents
Faktor-faktor yang mempengaruhi impor beras di Indonesia Tahun 2001-2019
Authors: Mashithoh Azzahra Dian , Amir Amri , Hodijah Siti
Published: January 2022

The objectives of this study are as follows: (1) To determine and analyze the development of rice imports, rice production, population, and rice consumption in Indonesia in 2001-2019. (2) To determine and analyze the effect of rice production, population, and rice consumption on rice imports in Indonesia in 2001-2019. Based on the research results, (1) Rice imports in Indonesia fluctuate every year, and the development of the population in Indonesia has increased. The effect of rice consumption in Indonesia fluctuates from year to year. The story of rice production in Indonesia also fluctuates. (2) The regression results show that the population has a positive and significant effect on rice imports in Indonesia. Rice consumption has a positive and significant effect on rice imports in Indonesia. Rice production does not affect rice imports in Indonesia.
 Keywords: Population, Rice consumption, Rice production
Pengaruh alokasi anggaran sektor pertanian dan industri terhadap PDRB di Kabupaten Kerinci
Authors: Aditama Raches , Ridwansyah M. , Artis Dearmi
Published: January 2022

This study aims to analyze the development of the agricultural and industrial sector budgets and analyze the effect of the farming and industrial sector budget allocations on the GRDP in the Kerinci district. The analytical method used is multiple linear regression with Ordinary Least Square (OLS). This study indicates that the development of the industrial sector budget in Kerinci Regency for the 2010 to 2020 period has fluctuated with an average growth of Rp. 36,920,377,491 per year and the average industrial sector budget in Kerinci Regency for the 2010 to 2020 period is Rp. 8,154,752,012 per year. And the results of the analysis of factors that affect GRDP in Kerinci Regency, simultaneously the agricultural and industrial sector budget variables have a significant effect on GRDP, and partially the industrial sector budget has a significant impact. The farm sector budget has no significant effect.
 Keywords: GRDP, Agriculture sector budget, Industry sector budget
GLOBALIZATION AND THE CHANGING CONCEPT OF NATO
Authors: Khan Umair Pervez , Sohail Kashaf
Published: January 2022

North Atlantic Treaty Organization (NATO) has been the most important and successful multilateral military cum political organization, pursuing the agenda of exporting democracy globally and ensuring the mutual defense of its allies. Historically, NATO was formed against the threat of communism emanating from USSR (Russia). The alliance did not use military option till the end of the cold war between the west and USSR, but post-cold war, it transformed and operated in Balkans, South Asia, Horn of Africa, and Middle East. The 9/11 incident further enhanced the military role of the organization and gave it ample reason to act internationally for ensuring the global security. America, being the leader of the alliance used it for fighting the so-called global war on terrorism and its adventures in Middle East. Nevertheless, in the last two decades the organization went through various changes and is now continuously in the state of transformation. The wave of populism which had influenced the very concept of globalization has posed serious challenges for the alliance. The Trump rhetoric of “America first”, BREXIT, challenges of migration, changing demography of Europe, assertion of Russia in global politics, confrontation between the NATO allies like Turkey and France, and rise of China are few factors which may affect the future of the so-called intergovernmental military alliance. This article concurrently discusses the new challenges for the NATO and sheds light on the possible options to the strategy of Biden administration to reverse the policies of its predecessor which have influenced the cooperation of different allies of NATO. In the end researcher has tried to put forth few recommendations which may help the policy makers to cope with the challenges NATO is facing. The study is qualitative and analytical in nature whereas primary as well as secondary sources are used for data collection.
ANÁLISE ESTRATÉGICA NERINT
Authors: Visentini Paulo , Ruchel Gabriela , Vieira Maria Gabriela , Martins José Miguel , Burmann da Costa João Gabriel , Geiger Luana Margarete , Da Conceição Guilherme Geremias , Thudium Guilherme , Pecequilo Cristina
Published: January 2022

The acceleration of pace of international events and processes requires qualified analysis beyond the political-journalistic bias that often characterises most interpretations of contemporary matters. Thus, in addition to theoretical-analytical articles, it was considered imperative to publish a brief evaluation of important current events. To this end, the Brazilian Centre for Strategy and International Relations (NERINT/UFRGS), a member of the Centre for International Studies on Government (CEGOV/UFRGS), launched the NERINT Strategic Analysis series, with the contribution of its specialised researchers and guests with thematic expertise, which will be published at the end of every issue of AUSTRAL: Brazilian Journal of Strategy and International Relations.
Valoración de una situación didáctica para la enseñanza de variable aleatoria y distribución de probabilidad en la educación secundaria chilena
Authors: Bizet Leyton Valeria , Ramos Rodríguez Elisabeth
Published: January 2022

La variable aleatoria y su distribución de probabilidad son conceptos fundamentales de tratar en la educación estadística y probabilística escolar, debido a que se manifiestan en experiencias cotidianas. Aun así, su enseñanza se hace compleja debido, prioritariamente, a las dificultades asociadas a la comprensión de estas y el concepto de función. Por tanto, se propone como objetivo de estudio valorar un proceso de instrucción de la variable aleatoria y su distribución de probabilidad en la educación secundaria chilena, fundamentado en la Teoría de Situaciones Didácticas (TSD) y la Teoría de Registro de Representaciones Semiótica (TRRS). Bajo la perspectiva cualitativa y con un enfoque descriptivo-interpretativo, se construye un test que contiene una situación didáctica, la cual fue aplicada a 22 estudiantes chilenos de grado 10 (15 a 16 años). Los hallazgos evidenciaron que más de la mitad de los estudiantes (64 %), logró identificar y representar en lenguaje verbal, figural o tabular, la variable aleatoria, y un porcentaje similar (59 %), su distribución de probabilidad. Desde la TRRS, esto podría indicar que los estudiantes están en vías de construcción de ambos objetos. Desde la TSD, se observa el importante rol que cumplió el profesor en las fases de una situación didáctica. Estudiar, desde teorías didácticas, cómo llevar al aula objetos complejos de enseñar, puede ayudar a profesores en ejercicio y en formación a mirar su práctica con mayor fundamento, para hacerla más accesible y comprensible a sus estudiantes.
Estrategias inclusivas: atención al estudiantado con diversidad en educación básica, experiencia del profesorado hondureño
Authors: Mejia–Elvir Percy
Published: January 2022

El manuscrito presenta experiencias en estrategias y metodologías de enseñanza – aprendizaje del personal académico docente hondureño en la inclusión educativa de la niñez con necesidades educativas especiales. La unidad de análisis estuvo constituida por diez personas que tuvieran experiencia en la inclusión en nivel primario y básico educativo. El enfoque utilizado fue cualitativo, mediante un diseño de tipo fenomenológico; los instrumentos utilizados para la obtención de la información fueron dos: el primero, la entrevista narrativa, y el segundo, el grupo focal, administrándose un guion de once preguntas en la entrevista y diez en el grupo focal. Los resultados permitieron entender que sobresalen las estrategias cooperativas y participativas, a fin de armonizar sus habilidades y las relaciones sociales en el aula. Aunque no existe una formación sólida en este ámbito, se recurrió a la capacidad creativa e inventiva para configurar ambientes inclusivos. En conclusión, los apoyos para la atención a la diversidad son minúsculos, se sugiere realizar otros estudios relacionados con las ayudas que se otorgan en los planteles educativos para perfeccionar las habilidades en la atención a la diversidad.
Polivictimización reportada por escolares chilenos: ¿es la escuela un lugar donde sentirse a salvo?
Authors: Rodríguez Garcés Carlos , Claudia Claudia , Padilla Fuentes Geraldo , Espinosa Valenzuela Denisse
Published: January 2022

La exposición a episodios de violencia, ya sea en el barrio, la familia o la escuela, tiende a formar parte de la cotidianidad de niños, niñas y adolescentes (NNA). En tal sentido, el objetivo de este artículo es analizar la simultaneidad y frecuencia de los eventos de violencia reportados por los NNA en calidad de víctimas, fenómeno tipificado como polivictimización. A nivel muestral, hace uso de la Primera Encuesta Nacional de Polivictimización aplicada a estudiantes chilenos/as entre 7° Básico y 3° Medio, aplicando un diseño metodológico de análisis estadístico inferencial y de regresión logística, estimando el nivel de vulnerabilidad y violencia a la que están expuestos los NNA y sus factores de protección y riesgo. Los resultados muestran que la victimización y polivictimización es declarada por gran parte de los y las participantes, lo que haría de ambas problemáticas algo transversal en el sistema educativo. Sobresalen los delitos comunes, la victimización indirecta y la realizada por pares, especialmente la recepción o atestiguamiento de ataques, golpes y amenazas. Las conclusiones destacan la necesidad de medidas integrales que tengan a la escuela como espacio crucial de fomento a la sana convivencia y rechazo de la violencia en cualquiera de sus formas.
Uso del personaje principal en el modelo hipermoderno de cine Iberoamericano. Análisis de la película Doña Clara de Kleber de Mendonça Filho.
Authors: López Iglesias Matías
Published: January 2022

Se disecciona la obra Doña Clara, obra del director de cine Kleber Mendonça Filho, como muestra de análisis identificativa del cine iberoamericano contemporáneo. De metodología cuantitativa, los datos se analizan centrándose en la aparición de personajes y localizaciones. El estudio analiza estadísticamente las correlaciones de planos escenas y secuencias.  Averiguando una prevalencia de un personaje y localización principal que determina la existencia narrativa semejable al cine hipermoderno.  El fin del estudio es proponer esta película como modelo de cine paradigmático iberoamericano. El personaje principal representado por Doña Clara e interpretada por Sonia Braga ejerce una posición predominante que sostiene toda la obra, el resto de personajes a modo de coreografía encarnan el resto de la sociedad. Las conclusiones presentan el cine como arte visual que representa fielmente el momento histórico por el que pasa la sociedad iberoamericana.
O pacifista que criou a Bomba Atômica: Guerra, política e ética científica no filme O Início do Fim (1989)
Authors: Silva Ademir Luiz da , Oliveira Solemar Silva
Published: January 2022

Resumo: o objetivo desse artigo é discutir os aspectos éticos e políticos que movimentaram os bastidores do Projeto Manhattan, responsável por criar a Bomba Atômica durante a década de 1940, conforme dramatizada no filme O Início do Fim, lançado em 1989 pelo diretor Roland Joffe. Propomos uma abordagem interdisciplinar que intercala história da Ciência e análise crítica de relatos documentais. As figuras centrais discutidas no texto são o cientista J. Robert Oppenheimer e o general Leslie Groves, principais responsáveis pela condução do Projeto Manhattan e protagonistas do filme.
Plataformização dos festivais de cinema e audiovisual a experiência do MixBrasil
Authors: Massarolo João Carlos , Mesquita Dario , Fischer André , Erthal Cláudia
Published: January 2022

A plataformização das indústrias culturais propiciou o surgimento de manifestações artísticas inovadoras nas plataformas de entretenimento: filmes, séries, shows musicais  e performances teatrais. Este trabalho pretende discutir a plataformização de festivais de Cinema, em especial, a experiência do festival MixBrasil.
Growth and Results of Three Varieties Celery (Apium graveolens L) With Addition of Alternative Nutrition in the Hydroponic Floating System
Authors: Isnainun Eva , Tini Etik Wukir , Suwarto Suwarto
Published: January 2022

The objectives of the research were to determine the best varieties of celery and nutrient concentration with the addition of azolla extract for growth and yield of celery, and obtaining the best combination of varieties and nutrient concentrations for growth and yield of celery in the hydroponic floating system. The research was conducted at Screen house number A. 24 and the Laboratory of Agronomy and Horticulture, Faculty of Agriculture, Jenderal Soedirman University and was conducted from January 2020 to April 2020. The research was arranged in a two-factorial randomized block design. The first factors were varieties treatment (V): V1 (Summer variety), V2 (Amigo variety), V3 (Tall Utah variety). The second factors were treatment of nutrient concentration (K): K1 (AB mix solution 900 ppm + azolla extract 60 ml / l), K2 (AB mix solution 1100 ppm + azolla extract 60 ml / l), K3 (AB mix solution 1300 ppm + azolla extract 60 ml / l), K4 (AB mix solution 1500 ppm without azolla extract). The research variables observed were plant height, number of leaves, amount of chlorophyll, fresh root weight, dry root weight, fresh shoot weight, dry shoot weight, root length and number of stalks. The results showed that the Tall Utah variety and the nutrient concentration of 1300 ppm + 60 ml / l azolla extract was the best treatment for growth and yield of celery. The interaction between the two treatments of Tall Utah varieties and nutrient concentrations of 1300 ppm + azolla extract 60ml / l showed the best treatment on the variable number of leaves 39.16, total chlorophyll 49.91, fresh root weight 7.57 g, dry root weight 0, 73 g, dry shoot weight 2.11 g, root length 9.11 cm, and the number of petioles 8.94 pieces.
ANTHOCYANIN LEVELS AND ANTIOXIDANT ACTIVITY OF TORTILLA PURPLE SWEET POTATO (Ipomoea batatas L)
Authors: Basrin Fitriani , Berlian Miming , Indriasari Yuanita , Chaniago Ramadhani
Published: January 2022

Purple sweet potato is a source of anthocyanins that function as antioxidants, antimutagenic, and anti-carcinogenic so that it has the potential to be processed into various functional food products. The stability of anthocyanin levels in the product is greatly influenced by temperature during processing, where the use of high temperatures will damage and reduce anthocyanin levels. This research was conducted to determine the effect of processing and combination of raw materials on anthocyanin levels and antioxidant activity of tortilla products made from a combination of purple sweet potato (Ipomoea batatas L) and cassava. The research design used a completely randomized design, with the object of research being tortillas made from purple sweet potato obtained from Palolo District, Sigi Regency, Central Sulawesi Province, combined with cassava obtained from the local market in Palu City, Central Sulawesi Province. The results showed that the anthocyanin levels of tortilla products varied from 5% (P1) to 19.63% (P5). There was a very significant decrease in anthocyanin levels around 68.26 - 91.91%. The amount of antioxidant activity was measured by IC50, wherefrom the research it was known that the IC50 value of tortilla products ranged from 242.68 to 155.66 µg / ml which indicated that the antioxidant activity of tortilla products was weak and even almost inactive. Based on the results of the study, it is indicated that the processing of purple sweet potatoes into tortillas is not appropriate because the processing is predominantly using high temperatures so that it can damage the anthocyanin content and reduce antioxidant activity.
Complete genome analysis of African swine fever virus isolated from domestic pigs during the first ASF outbreaks in India.
Authors: D Senthilkumar , RAJUKUMAR KATHERUKAMEM , G Venkatesh , Singh Fateh , Tosh C. , Kombiah Subbiah , Dubey Chandan , CHAKRAVARTY AMITAV , Barman Nagendra Nath , Singh Vijendra
Published: January 2022

African swine fever (ASF), considered as the most dreadful swine disease
due to its very high mortality, emerged in India in 2020. The complete
genome analysis of ASF viruses isolated during the first outbreaks in
India showed a few unique non-synonymous mutations in MGF 369-11L, MGF
505-4R, K205R and B263R genes. Frame shiftsin the protein coding
sequences were observed in DP60R, ASFV-G_ACD 00190, MGF 110-10-L-
MGF110-14L fusion, MGF 360-14L and I267L genes of Indian ASFVs as
compared to ASFV/Georgia/2007. Complete genome based phylogenetic
analysis of p72-genotype-II viruses showed the clustering of Indian
isolates with ASFV/Wuhan/2019 in a separate clade. Phylogenetic analysis
of concatenated sequences of 14 open reading frames (ORF) having single
nucleotide polymorphisms (SNP) showed distinct grouping of Indian ASFVs
with other Asian ASFVs.Thisis the first complete genome characterization
of ASF viruses isolated from domestic pigs in India. The resultsindicate
that number of Tandem Repeat Sequence in the intergenic region between
I73R and I329L genes, and the 14 ORFs with SNP reported in this study
could be the genetic determinants to differentiate the closely related
p72-genotype II viruses circulating in Asia.
Meditation reduces brain activity in the default mode network in children with cancer
Authors: Hehr Aneesh , Iadipaolo Allesandra , Morales Austin , Cohen Cindy , Taub Jeffrey , Harper Felicity , Goldberg Elimelech , Bluth Martin , Rabinak Christine , Marusak Hilary
Published: January 2022

Background: Mounting evidence demonstrates that meditation can lower
pain and emotional distress in adults, and more recently, in children.
Meditation may be an effective form of emotion regulation in children
because it is easily accessible and more easily done across a variety of
settings in which toys may not be available, for e.g., settings
requiring a “clean” environment (e.g., surgical prep). Further,
neuroimaging studies in adults suggest that meditation techniques are
neurobiologically distinct from other forms of emotion regulation, such
as distraction, that rely on prefrontal control mechanisms, which are
underdeveloped in youth. Rather, meditation techniques may not rely on
“top-down” prefrontal control and may therefore be utilized across the
lifespan. Procedure: We examined neural activation in children with
cancer, who experience significant distress. During neuroimaging,
children viewed distress-inducing video clips while using martial
arts-based meditation (focused attention, mindful acceptance) or
non-meditation (distraction) emotion regulation techniques. In a third
condition (control), participants passively viewed the video clip.
Results: We found that meditation techniques were associated with lower
activation in default mode network (DMN) regions, including the medial
frontal cortex, precuneus, and posterior cingulate cortex, compared to
the control condition. Additionally, we found evidence that meditation
techniques may be more effective for modulating DMN activity than
distraction. There were no differences in self-reported distress ratings
between conditions. Conclusion: Together, these findings suggest that
martial arts-based meditation modulates negative self-referential
processing associated with the DMN, and may have implications for the
management of pediatric pain and negative emotion.