bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbon Monoxide Diffusion Capacity as a Severity Marker in Pulmonary Hypertension
Authors: Diamanti Eleni , Karava Vasiliki , Yerly Patrick , Aubert John David
Published: December 2021

Carbon monoxide diffusion capacity (DLCO) is negatively associated with patient survival in idiopathic pulmonary hypertension (PH), but is not included in the risk stratification score proposed by the 2015 European guidelines. Since 2015, several new stratification scores based on a 3- or 4-severity scale have been explored. This retrospective cohort single-center study sought to investigate the association between DLCO and PH severity and survival. We included 85 treatment-naive patients with precapillary PH and DLCO measurement at diagnosis. DLCO status, based on lower and upper quartiles ranges, was added to a 3- and a 4-strata modified-risk assessment. DLCO was strongly associated with transplant-free survival (HR 0.939, 95% CI: 0.908–0.971, p < 0.001). In the intermediate and high-risk categories, DLCO was associated with transplant-free survival, irrespective of the risk category (HR 0.934, 95% CI: 0.880–0.980, p = 0.005). The correlation between modified-risk category and transplant-free survival was significant (HR 4.60, 95% CI: 1.294–16.352, p = 0.018). Based on the Akaike information criterion (AIC) levels, the 3- and 4-strata modified-risk stratification fits our results better than the conventional stratification. Low DLCO is associated with patient transplant-free survival, independently of the risk category. Inclusion of DLCO into a PH risk stratification score seems promising and needs further investigation.
Evaluation of Functional Outcomes and Quality of Life in Elderly Patients (>75 y.o.) Undergoing Minimally Invasive Radical Cystectomy with Single Stoma Ureterocutaneostomy vs. Bricker Intracorporeal Ileal Conduit Urinary Diversion
Authors: Fuschi Andrea , Al Salhi Yazan , Sequi Manfredi Bruno , Velotti Gennaro , Martoccia Alessia , Suraci Paolo Pietro , Scalzo Silvio , Asimakopoulos Anastasios , Bozzini Giorgio , Zucchi Alessandro , De Nunzio Cosimo , Carbone Antonio , Pastore Antonio Luigi
Published: December 2021

Background: Diversion after radical cystectomy (RC) is crucial when considering elderly subjects. Data on the quality of life (QoL) impact with different diversions is scarce. This study aims to compare complications and QoL in patients aged > 75 y.o., who underwent minimally invasive (MI) RC with Bricker intracorporeal urinary derivation and single stoma ureterocutaneostomy. Methods: We conducted a retrospective analysis of elderly patients who underwent MIRC and intracorporeal diversion. The 78 subjects were divided into two groups: group A, ileal conduit, and group B, single stoma ureterocutaneostomy. We evaluated the bowel’s recovery time and complications rate. We investigated QoL 3 and 6 months after surgery using the Stoma-QoL questionnaire. Results: Mean age was 77.2 in group A and 82.4 in group B. The mean ASA score and Charlson Comorbidity index were comparable between the two groups. Rates of complications were 57.6% and 37.4% in groups A and B, respectively. The mean postoperative Stoma-QoL score 3 months after surgery was 52.2 and 52.4 in groups A and B, respectively. At 6 months of follow-up the Stoma QoL mean score was 63.4, showing homogeneity between the groups. Conclusion: MIRC with single stoma ureterocutaneostomy represents an alternative to ileal conduit, with comparable QoL and ostomy management 6 months after surgery, reporting fewer complications.
Effects of SGLT2 Inhibitors on Atherosclerosis: Lessons from Cardiovascular Clinical Outcomes in Type 2 Diabetic Patients and Basic Researches
Authors: Xu Jing , Hirai Taro , Koya Daisuke , Kitada Munehiro
Published: December 2021

Atherosclerosis-caused cardiovascular diseases (CVD) are the leading cause of mortality in type 2 diabetes mellitus (T2DM). Sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective oral drugs for the treatment of T2DM patients. Multiple pre-clinical and clinical studies have indicated that SGLT2 inhibitors not only reduce blood glucose but also confer benefits with regard to body weight, insulin resistance, lipid profiles and blood pressure. Recently, some cardiovascular outcome trials have demonstrated the safety and cardiovascular benefits of SGLT2 inhibitors beyond glycemic control. The SGLT2 inhibitors empagliflozin, canagliflozin, dapagliflozin and ertugliflozin reduce the rates of major adverse cardiovascular events and of hospitalization for heart failure in T2DM patients regardless of CVD. The potential mechanisms of SGLT2 inhibitors on cardioprotection may be involved in improving the function of vascular endothelial cells, suppressing oxidative stress, inhibiting inflammation and regulating autophagy, which further protect from the progression of atherosclerosis. Here, we summarized the pre-clinical and clinical evidence of SGLT2 inhibitors on cardioprotection and discussed the potential molecular mechanisms of SGLT2 inhibitors in preventing the pathogenesis of atherosclerosis and CVD.
Factors Affecting Long-Term Compliance of CPAP Treatment—A Single Centre Experience
Authors: Gabryelska Agata , Sochal Marcin , Wasik Bartosz , Szczepanowski Przemysław , Białasiewicz Piotr
Published: December 2021

Continuous positive airway pressure (CPAP) has been the standard treatment of obstructive sleep apnoea/hypopnoea syndrome (OSA) for almost four decades. Though usually effective, this treatment suffers from poor long-term compliance. Therefore, the aim of our one centre retrospective study was to assess factors responsible for treatment failure and long-term compliance. Four hundred subsequent patients diagnosed with OSA and qualified for CPAP treatment were chosen from our database and compliance data were obtained from medical charts. Many differing factors kept patients from starting CPAP or led to termination of treatment. Overall, almost half of patients ended treatment during the mean time of observation of 3.5 years. Survival analysis revealed that 25% of patients failed at a median time of 38.2 months. From several demographic and clinical covariates in Cox’s hazard model, only the presence of a mild OSA, i.e., AHI (apnoea/hypopnoea index) below 15/h was a factor strongly associated with long term CPAP failure. The compliance results of our study are in line with numerous studies addressing this issue. Contrary to them, some demographic or clinical variables that we used in our survival model were not related to CPAP adherence.
Effectiveness of S-O Clip-Assisted Colorectal Endoscopic Submucosal Dissection
Authors: Fujinami Haruka , Teramoto Akira , Takahashi Saeko , Ando Takayuki , Kajiura Shinya , Yasuda Ichiro
Published: December 2021

This study aimed to assess the utility of the S-O clip during colorectal endoscopic submucosal dissection (ESD). We conducted a retrospective study on 185 patients who underwent colorectal ESD from January 2015 to January 2020. The patients were divided into two groups: before and after the introduction of the S-O clip. Forty-two patients underwent conventional ESD (CO group) and 29 patients underwent ESD using the S-O clip (SO group). We compared the surgery duration, dissection speed, en bloc resection rate, and complication rate between both groups. Compared with the CO group, the SO group had a significantly shorter surgery duration (70.7 ± 37.9 min vs. 51.2 ± 18.6 min; p = 0.017), a significantly higher dissection speed (15.1 ± 9.0 min vs. 26.3 ± 13.8 min; p < 0.001), a significantly higher en bloc resection rate (80.9% vs. 98.8%; p ≤ 0.001), and a significantly lower perforation rate (4.3% vs. 1.3%). In the right colon, the surgery duration was significantly shorter and the dissection speed was significantly higher in the SO group than in the CO group. Moreover, the rate of en bloc resection improved significantly in the right colon. S-O clip-assisted ESD reduces the procedure time and improves the treatment effects, especially in the right colon.
Cerebellar Transcranial Direct Current Stimulation in Children with Autism Spectrum Disorder: A Pilot Study on Efficacy, Feasibility, Safety, and Unexpected Outcomes in Tic Disorder and Epilepsy
Authors: D’Urso Giordano , Toscano Elena , Sanges Veronica , Sauvaget Anne , Sheffer Christine E. , Riccio Maria Pia , Ferrucci Roberta , Iasevoli Felice , Priori Alberto , Bravaccio Carmela , de Bartolomeis Andrea
Published: December 2021

Patients with autism spectrum disorder (ASD) display distinctive neurophysiological characteristics associated with significant cognitive, emotional, and behavioral symptoms. Transcranial direct current stimulation (tDCS) applied to the frontal or temporoparietal lobes has demonstrated potential to reduce the severity of ASD-related symptoms. Recently, the cerebellum has been identified as a brain area involved in ASD pathophysiology. In this open-label pilot study, seven ASD patients aged between 9 and 13 years underwent 20 daily sessions of 20 min cathodal stimulation of the right cerebellar lobe. At the end of the treatment, the Aberrant Behavior Checklist (ABC) scores showed a 25% mean reduction in global severity of symptoms, with a more pronounced reduction in the “social withdrawal and lethargy” (−35%), “hyperactivity and noncompliance” (−26%), and “irritability, agitation, and crying” (−25%) subscales. Minor and no improvement were observed in the “stereotypic behavior” (−18%) and “inappropriate speech” (−0%) subscales, respectively. Improvements were not detected in the two patients who were taking psychotropic drugs during the study. Clinical response showed a symptom-specific time course. Quality of sleep and mood improved earlier than hyperactivity and social withdrawal. The treatment was generally accepted by patients and well tolerated. No serious adverse events were reported. Stimulation also appeared to markedly reduce the severity of tics in a patient with comorbid tic disorder and led to the disappearance of a frontal epileptogenic focus in another patient with a history of seizures. In conclusion, cerebellar tDCS is safe, feasible, and potentially effective in the treatment of ASD symptoms among children. Strategies to improve recruitment and retention are discussed.
Operator Performance of the Digital Setup Fabrication for Orthodontic–Orthognathic Treatment: An Explorative Study
Authors: de Waard Olivier , Bruggink Robin , Baan Frank , Reukers Hendrikus A. J. , Bronkhorst Ewald M. , Kuijpers-Jagtman Anne Marie , Ongkosuwito Edwin M.
Published: December 2021

The purpose of this study was to explore the operator performance of the fabrication of digital orthodontic setups integrated into cone beam computed tomography (CBCT) scans. Fifteen patients who underwent a combined orthodontic–orthognathic surgical treatment were included. The pre-treatment digital dental models and CBCT scans were fused, and four operators made virtual setups twice for all patients. Differences between the virtual setups were calculated by recording tooth crown movement from the pre-treatment model to the virtual setup. To examine performance, Pearson’s correlation coefficients, duplicate measurement errors, and inter-operator differences were calculated. For intra-operator performance, correlation values varied among tooth types, with mean correlation values from 0.66 to 0.83 for the maxilla and 0.70 to 0.83 for the mandible. For inter-operator performance, mean correlation values varied from 0.40 to 0.87 for the maxilla and from 0.44 to 0.80 for the mandible. Rotational mean differences exceeded the range of clinical acceptance (>2 degrees) at 18% for the maxilla and 20.8% for the mandible, and translational mean differences exceeded the range of clinical acceptance (0.6 mm) at 9.7% and 26% for the maxilla and mandible, respectively. The intra- and inter-operator performance of digital orthodontic setup construction for virtual three-dimensional orthognathic planning shows significant errors.
Radiation-Induced Heart Disease
Authors: Quintero-Martinez Juan A. , Cordova-Madera Sandra N. , Villarraga Hector R.
Published: December 2021

Cancer incidence and survivorship have had a rising tendency over the last two decades due to better treatment modalities. One of these is radiation therapy (RT), which is used in 20–55% of cancer patients, and its basic principle consists of inhibiting proliferation or inducing apoptosis of cancer cells. Classically, photon beam RT has been the mainstay therapy for these patients, but, in the last decade, proton beam has been introduced as a new option. This newer method focuses more on the tumor and affects less of the surrounding normal tissue, i.e., the heart. Radiation to the heart is a common complication of RT, especially in patients with lymphoma, breast, lung, and esophageal cancer. The pathophysiology is due to changes in the microvascular and macrovascular milieu that can promote accelerated atherosclerosis and/or induce fibrosis of the myocardium, pericardium, and valves. These complications occur days, weeks, or years after RT and the risk factors associated are high radiation doses (>30 Gy), concomitant chemotherapy (primarily anthracyclines), age, history of heart disease, and the presence of cardiovascular risk factors. The understanding of these mechanisms and risk factors by physicians can lead to a tailored assessment and monitorization of these patients with the objective of early detection or prevention of radiation-induced heart disease. Echocardiography is a noninvasive method which provides a comprehensive evaluation of the pericardium, valves, myocardium, and coronaries, making it the first imaging tool in most cases; however, other modalities, such as computed tomography, nuclear medicine, or cardiac magnetic resonance, can provide additional value.
Effectiveness of Radial Extracorporeal Shock Wave Therapy and Visual Feedback Balance Training on Lower Limb Post-Stroke Spasticity, Trunk Performance, and Balance: A Randomized Controlled Trial
Authors: Mihai Emanuela Elena , Mihai Ilie Valentin , Berteanu Mihai
Published: December 2021

Stroke remains one of the leading causes of disability in adults, and lower limb spasticity, affected stance, and balance impact everyday life and activities of such patients. Robotic therapy and assessment are becoming important tools to clinical evaluation for post-stroke rehabilitation. The aim of this study was to determine in a more objective manner the effects of visual feedback balance training through a balance trainer system and radial extracorporeal shock wave therapy (rESWT), along with conventional physiotherapy, on lower limb post-stroke spasticity, trunk control, and static and dynamic balance through clinical and stabilometric assessment. The study was designed as a randomized controlled trial. The experimental group underwent conventional physiotherapy, visual feedback balance training, and rESWT. The control group underwent conventional physiotherapy, visual feedback training and sham rESWT. The statistical analysis was performed using GraphPad Software and MATLAB. Primary clinical outcome measures were The Modified Ashworth Scale (MAS), passive range of motion (PROM), Visual Analogue Scale (VAS), and Clonus score. Secondary outcome measures were trunk performance, sensorimotor, and lower limb function. Stabilometric outcome measures were trunk control, static balance, and dynamic balance. Visual feedback training using the Prokin system and rESWT intervention, along with conventional physiotherapy, yielded statistically significant improvement both on clinical and stabilometric outcome measures, enhancing static and dynamic balance, trunk performance, sensorimotor outcome, and limb function and considerably diminishing lower limb spasticity, pain intensity, and clonus score in the experimental group.
Antibody Response to mRNA Vaccines against SARS-CoV-2 with Chronic Kidney Disease, Hemodialysis, and after Kidney Transplantation
Authors: Buchwinkler Lukas , Solagna Claire Anne , Messner Janosch , Pirklbauer Markus , Rudnicki Michael , Mayer Gert , Kerschbaum Julia
Published: December 2021

Most trials on mRNA vaccines against SARS-CoV-2 did not include patients with chronic kidney disease (CKD), hemodialysis (HD) patients, or kidney transplant recipients (KTR). However, those patients have a higher risk for a severe course of COVID-19 disease and mortality. Available literature has demonstrated a reduced efficacy of mRNA vaccines in HD patients and KTR, while data on CKD patients is scarce. Additionally, factors associated with non-response are poorly understood and not well characterized. We assessed antibody (AB) response (n = 582, 160 CKD patients, 206 patients on HD, 216 KTR) after the administration of two doses of a mRNA-vaccine with either BNT162b2 or mRNA-1273. AB measurements were carried out after a median of 91 days after first vaccinations, demonstrating non-response in 12.5% of CKD patients, 12.1% of HD patients, and 50% of KTR. AB titers were significantly higher in CKD patients than in HD patients or KTR. Factors associated with non-response were treated with rituximab in CKD patients, the use of calcineurin inhibitors in HD patients and older age, and the use of BNT162b2, mycophenolic acid, or glucocorticoids and lower hemoglobin levels in KTR. This study contributes to the understanding of the extent and conditions that predispose for non-response in patients with impaired kidney function.
Physical Tests Are Poorly Related to Patient-Reported Outcome Measures during Severe Acute Exacerbations of COPD
Authors: Quadflieg Kirsten , Machado Ana , Haesevoets Sarah , Daenen Marc , Thomeer Michiel , Ruttens David , Spruit Martijn A. , Burtin Chris
Published: December 2021

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a negative impact on patients’ health status, including physical function and patient-reported outcomes. We aimed to explore the associations between physical tests and patient-reported outcome measures (PROMs) in hospitalised patients for an AECOPD. Patients were assessed on the day of discharge. Quadriceps force, handgrip strength, short physical performance battery (SPPB), five-repetition sit-to-stand test (5STS), four-meter gait speed test (4MGS), balance test, six-minute walk test (6MWT), COPD Assessment Test (CAT), London Chest Activity of Daily Living scale (LCADL), modified Medical Research Council (mMRC) dyspnea scale, Checklist of Individual Strength (CIS)-fatigue subscale, and Patient Health Questionnaire (PHQ-9) were collected. Sixty-nine patients with an AECOPD were included (54% female; age 69 ± 9 years; FEV1 39.2 (28.6–49.1%) predicted). Six-minute walk distance was strongly correlated with mMRC (ρ: −0.64, p < 0.0001) and moderately correlated with LCADL total score, subscales self-care and household activities (ρ ranging from −0.40 to −0.58, p < 0.01). Moreover, 4MGS was moderately correlated with mMRC (ρ: −0.49, p < 0.0001). Other correlations were weak or non-significant. During a severe AECOPD, physical tests are generally poorly related to PROMs. Therefore, a comprehensive assessment combining both physical tests and PROMs needs to be conducted in these patients to understand their health status.
Validation and Cross-Cultural Adaptation of the Spanish Version of the Pain Sensitivity Questionnaire (PSQ-S)
Authors: Ibancos-Losada María del Rocío , Osuna-Pérez María Catalina , Cortés-Pérez Irene , Montoro-Cárdenas Desirée , Díaz-Fernández Ángeles
Published: December 2021

Experimental pain testing requires specific equipment and may be uncomfortable for patients. The Pain Sensitivity Questionnaire (PSQ) was developed to assess pain sensitivity, based on the pain intensity ratings (range: 0–10) of painful situations that occur in daily life. The main objective of this study was to carry out a cross-cultural adaptation and validation of the Spanish version of the PSQ (PSQ-S). A total of 354 subjects (296 healthy and 58 chronic pain patients) filled in the PSQ-S. A subgroup of 116 subjects performed experimental pain testing, including two modalities (cold and pressure), with different measures: pain intensity rating, pressure pain threshold, and tolerance. The validation results showed two factors: PSQ-S-moderate and PSQ-S-minor and, for the total scale and the two factors, an excellent internal consistency (Cronbach’s alpha coefficient > 0.9) and a substantial reliability (Intraclass Correlation Coefficient > 0.8). We obtained strong correlations with all the experimental pain rating parameters, catastrophizing, and depression variables, as well as moderate correlations with anxiety, central sensibilization, and impact on the quality of life. Chronic pain patients received elevated PSQ-S scores compared to healthy controls, and three cut-off values (PSQ-S-total = 7.00, PSQ-S-moderate = 7.57, and PSQ-S-minor = 6.29) based on ROC curve analyses were shown to be able to discriminate between healthy adults and adults with chronic pain. Therefore, PSQ-S may be a simple alternative to experimental pain procedures for clinical and experimental pain research.
Assessment of Asymptomatic Severe Aortic Regurgitation by Doppler-Derived Echo Indices: Comparison with Magnetic Resonance Quantification
Authors: Hlubocká Zuzana , Kočková Radka , Línková Hana , Pravečková Alena , Hlubocký Jaroslav , Dostálová Gabriela , Bláha Martin , Pěnička Martin , Linhart Aleš
Published: December 2021

Reliable quantification of aortic regurgitation (AR) severity is essential for clinical management. We aimed to compare quantitative and indirect echo-Doppler indices to quantitative cardiac magnetic resonance (CMR) parameters in asymptomatic chronic severe AR. Methods and Results: We evaluated 104 consecutive patients using echocardiography and CMR. A comprehensive 2D, 3D, and Doppler echocardiography was performed. The CMR was used to quantify regurgitation fraction (RF) and volume (RV) using the phase-contrast velocity mapping technique. Concordant grading of AR severity with both techniques was observed in 77 (74%) patients. Correlation between RV and RF as assessed by echocardiography and CMR was relatively good (rs = 0.50 for RV, rs = 0.40 for RF, p < 0.0001). The best correlation between indirect echo-Doppler and CMR parameters was found for diastolic flow reversal (DFR) velocity in descending aorta (rs = 0.62 for RV, rs = 0.50 for RF, p < 0.0001) and 3D vena contracta area (VCA) (rs = 0.48 for RV, rs = 0.38 for RF, p < 0.0001). Using receiver operating characteristic analysis, the largest area under curve (AUC) to predict severe AR by CMR RV was observed for DFR velocity (AUC = 0.79). DFR velocity of 19.5 cm/s provided 78% sensitivity and 80% specificity. The AUC for 3D VCA to predict severe AR by CMR RV was 0.73, with optimal cut-off of 26 mm2 (sensitivity 80% and specificity 66%). Conclusions: Out of the indirect echo-Doppler indices of AR severity, DFR velocity in descending aorta and 3D vena contracta area showed the best correlation with CMR-derived RV and RF in patients with chronic severe AR.
Anti-Gnawing, Thermo-Mechanical and Rheological Properties of Polyvinyl Chloride: Effect of Capsicum Oleoresin and Denatonium Benzoate
Authors: Techawinyutham Laongdaw , Prasarnsri Arnuparb , Siengchin Suchart , Dangtungee Rapeephun , Rangappa Sanjay Mavinkere
Published: December 2021

Anti-rodent polymer composites were prepared using non-toxic substances denatonium benzoate (DB) and capsicum oleroresin (CO) mixed with polyvinyl chloride (PVC) matrix. DB is mixed in zinc stearate (ZnSt) called DB/ZnSt, and CO, providing burning sensation, is impregnated in mesoporous silica named SiCO. There are three sets of sample: Blank, composites Set I and Set II. Set I consists of DB/ZnSt at concentration of 1.96 wt% and SiCO at concentration of 12.16 wt%, 14.47 wt%, 18.75 wt% and 23.53 wt%. Set II comprises SiCO at the same amount of Set I. The anti-rodent composites studied are anti-gnawing, surface morphology, thermo-mechanical and rheological properties. Anti-rodent testing is analyzed by one-way blocked analysis of variance (ANOVA) and compared with Tukey test with a 95% level of significance, presenting good anti-gnawing efficiency. The best rat-proof sample is II.4, consisting of SiCO 23.53 wt%, which presents percentage of weight loss from gnawing at 1.68% compared to weight loss of neat PVC at 59.74%. The addition of SiCO at concentration ranging from 12.16 to 23.53 wt% reduces tensile strength around 25–50%, elongation at break strength around 2–23%, shear storage modulus (G′) around 30%, shear loss modulus (G″) shear viscosity (η) and glass transition (Tg) around 43% compared to Blank. The increase in SiCO concentration slightly improves the thermal stability of PVC composites around 3%, but the addition of DB/ZnSt at 1.96 wt% slightly reduces those properties.
Numerical and Experimental Investigation of the Performance of Dynamic Wing for Augmenting Ship Propulsion in Head and Quartering Seas
Authors: Belibassakis Kostas , Filippas Evangelos , Papadakis George
Published: December 2021

Flapping-foil thrusters arranged at the bow of the ship are examined for the exploitation of energy from wave motions by direct conversion to useful propulsive power, offering at the same time dynamic stability and reduction of added wave resistance. In the present work, the system consisting of the ship and an actively controlled wing located in front of its bow is examined in irregular waves. Frequency-domain seakeeping analysis is used for the estimation of ship-foil responses and compared against experimental measurements of a ferry model in head waves tested at the National Technical University of Athens (NTUA) towing tank. Next, to exploit the information concerning the responses from the verified seakeeping model, a detailed time-domain analysis of the loads acting on the foil, both in head and quartering seas, is presented, as obtained by means of a cost-effective time-domain boundary element method (BEM) solver validated by a higher fidelity RANSE finite volume solver. The results demonstrate the good performance of the examined system and will further support the development of the system at a larger model scale and the optimal design at full scale for specific ship types.
Kriging Model for Reliability Analysis of the Offshore Steel Trestle Subjected to Wave and Current Loads
Authors: Liu Pengfei , Shang Daimeng , Liu Qiang , Yi Zhihong , Wei Kai
Published: December 2021

Offshore steel trestles (OSTs) are exposed to severe marine environments with stochastic wave and current loads, making structural safety assessment challenging and difficult. Reliability analysis is a suitable way to consider both wave and current loading intensity uncertainties, but the implicit and complex limit state functions of the reliability analysis usually imply huge computational costs. This paper proposes an efficient reliability analysis framework for OST using the kriging model of optimal linear unbiased estimation. The surrogate model is built with stochastic waves, current parameters, and the corresponding load factors. The framework is then used to evaluate the reliability of an example OST subjected to wave and current loads at three limit states of OST, including first yield (FY), full plastic (FP), and collapse initiation (CI). Three different distributions are used for comparison of the results of failure probability and reliability index. The results and the computational cost by the proposed framework are compared with that from the Monte Carlo sampling (MCS) and Latin hypercube sampling (LHS) method. The influences of sample number on the prediction accuracy and reliability index are investigated. The influence of marine growth on the reliability analysis of the OST is discussed using MCS and the kriging model. The results show that the reliability analysis based on the kriging model can obtain the reliability index for the OST efficiently with less calculation time but similar results compared with MCS and LHS. With the increase of the number of samples, the prediction accuracy of the kriging model increases, and the corresponding failure probability fluctuates greatly at first and then tends to be stable. The reliability of the example OST is reduced with the increase of marine growth, regardless of the limit state.
Open Digital Shoreline Analysis System: ODSAS v1.0
Authors: Gómez-Pazo Alejandro , Payo Andres , Paz-Delgado María Victoria , Delgadillo-Calzadilla Miguel A.
Published: December 2021

In this study, we propose a new baseline and transect method, the open-source digital shoreline analysis system (ODSAS), which is specifically designed to deal with very irregular coastlines. We have compared the ODSAS results with those obtained using the digital shoreline analysis system (DSAS). Like DSAS, our proposed method uses a single baseline parallel to the shoreline and offers the user different smoothing and spacing options to generate the transects. Our method differs from DSAS in the way that the transects’ starting points and orientation are delineated by combining raster and vector objects. ODSAS uses SAGA GIS and R, which are both free open-source software programs. In this paper, we delineate the ODSAS workflow, apply it to ten study sites along the very irregular Galician coastline (NW Iberian Peninsula), and compare it with the one obtained using DSAS. We show how ODSAS produces similar values of coastline changes in terms of the most common indicators at the aggregated level (i.e., using all transects), but the values differ when compared at the transect-by-transect level. We argue herein that explicitly requesting the user to define a minimum resolution is important to reduce the subjectivity of the transect and baseline method.
Contemporary Molecular Analyses of Malignant Tumors for Precision Treatment and the Implication in Oral Squamous Cell Carcinoma
Authors: Chang Julia Yu Fong , Tseng Chih-Huang , Lu Pei Hsuan , Wang Yi-Ping
Published: December 2021

New molecular tests and methods, in addition to morphology-based diagnosis, are widely used as a new standard of care in many tumors. “One-size-fits-all medicine” is now shifting to precision medicine. This review is intended to discuss the key steps toward to development of precision medicine and its implication in oral squamous cell carcinoma. The challenges and opportunities of precision medicine in oral cancer will be sequentially discussed based on the four steps of precision medicine: identification/detection, diagnosis, treatment and monitoring.
Novel Mutations in GPR68 and SLC24A4 Cause Hypomaturation Amelogenesis Imperfecta
Authors: Seymen Figen , Zhang Hong , Kasimoglu Yelda , Koruyucu Mine , Simmer James P. , Hu Jan C.-C. , Kim Jung-Wook
Published: December 2021

Amelogenesis imperfecta (AI) is a rare genetic condition affecting the quantity and/or quality of tooth enamel. Hypomaturation AI is characterized by brownish-yellow discoloration with increased opacity and poorly mineralized enamel prone to fracture and attrition. We recruited three families affected by hypomaturation AI and performed whole exome sequencing with selected individuals in each family. Bioinformatic analysis and Sanger sequencing identified and confirmed mutations and segregation in the families. Family 1 had a novel homozygous frameshift mutation in GPR68 gene (NM_003485.3:c.78_83delinsC, p.(Val27Cysfs*146)). Family 2 had a novel homozygous nonsense mutation in SLC24A4 gene (NM_153646.4:c.613C>T, NP_705932.2:p.(Arg205*)). Family 3 also had a homozygous missense mutation in SLC24A4 gene which was reported previously (c.437C>T, p.(Ala146Val)). This report not only expands the mutational spectrum of the AI-causing genes but also improves our understanding of normal and pathologic amelogenesis.
New Multipath OLSR Protocol Version for Heterogeneous Ad Hoc Networks
Authors: Benjbara Chaimae , Habbani Ahmed , Mouchfiq Nada
Published: December 2021

From a basic refrigerator to a self-driving car, emerging technologies are increasingly involving various facets of our daily lives. These bring together many regularly used devices, each with its own characteristics, to communicate and collaborate within the same system. Computer network experts regard this so-called structure as a heterogeneous network made up of several connected objects that do not speak the same language. Communication is therefore ensured by additional types of nodes, such as gateways or converters. In this case, we can detect an increased complexity and a decreased level of security. And thus, the need to adopt a common slang for these kinds of networks has been brought to life. In this work, we compare two different routing protocols: optimized link-state routing (OLSR) and the multipath heterogeneous ad hoc network OLSR (MHAR-OLSR). The latter is an OLSR extension with new functionalities: nodes identification, paths calculation, paths classification, and paths choice that we designed for heterogeneous ad hoc networks composed of MANET, VANET, and FANET devices; it ensures direct communication between these diverse components. We verify and explain all the elements of our solution using colored Petri nets. We also present a global evaluation of Packet Delivery Ratio (PDR), End-To-End Delay, and energy consumption as QoS measures with different numbers of nodes in a heterogeneous scenario. To do this, we use NS-3 and BonnMotion as a tool-set of simulation. Experimental results show improvement in performance when compared to the classical routing protocol.
Cross-Border E-Commerce Development and Challenges in China: A Systematic Literature Review
Authors: Liu Aijun , Osewe Maurice , Shi Yangyan , Zhen Xiaofei , Wu Yanping
Published: December 2021

This paper reviews the primary scientific articles applicable to the logistics industry, and specifically those relating to cross-border e-commerce in China. The authors focused on reviewing the articles about the current status of cross-border e-commerce in China and the factors affecting its development, with the aim of highlighting literature gaps. The authors used a systematic literature review (SLR) to identify, gather, and analyze 60 primary papers selected from international peer-reviewed journals and international conference proceedings between 2001 and 2020. Chinese cross-border e-commerce has experienced a trend of steady progress, although several challenges remain. These challenges include, but are not limited to, low custom clearance efficiency, complex monitoring and supervision, tax rebate settlement challenges, payment risks, insufficient talent within the Chinese industry, and the lack of scientific management guidelines. The significant contributions of this paper include critical highlights of the current gaps and future research themes.
Qualitative Modeling for Bridging Expert-Knowledge and Social-Ecological Dynamics of an East African Savanna
Authors: Cosme Maximilien , Hély Christelle , Pommereau Franck , Pasquariello Paolo , Tiberi Christel , Treydte Anna , Gaucherel Cédric
Published: December 2021

Sub-Saharan social-ecological systems are undergoing changes in environmental conditions, including modifications in rainfall pattern and biodiversity loss. Consequences of such changes depend on complex causal chains which call for integrated management strategies whose efficiency could benefit from ecosystem dynamic modeling. However, ecosystem models often require lots of quantitative information for estimating parameters, which is often unavailable. Alternatively, qualitative modeling frameworks have proved useful for explaining ecosystem responses to perturbations, while only requiring qualitative information about social-ecological interactions and events and providing more general predictions due to their validity for wide ranges of parameter values. In this paper, we propose the Ecological Discrete-Event Network (EDEN), an innovative qualitative dynamic modeling framework based on “if-then” rules generating non-deterministic dynamics. Based on expert knowledge, observations, and literature, we use EDEN to assess the effect of permanent changes in surface water and herbivores diversity on vegetation and socio-economic transitions in an East African savanna. Results show that water availability drives changes in vegetation and socio-economic transitions, while herbivore functional groups have highly contrasted effects depending on the group. This first use of EDEN in a savanna context is promising for bridging expert knowledge and ecosystem modeling.
Interaction and Grammar: Predicative Adjective Constructions in English Conversation
Authors: Bybee Joan , Thompson Sandra A.
Published: December 2021

This article studies the function of Copular Predicate Constructions in everyday English conversation. We compare predicate adjective constructions (PA) and constructions with a predicate nominal containing an adjective (PAN). We ask whether the attributive function of the adjective or the presence of a noun in the PAN leads to a difference in function in the two constructions. We propose that in most cases the adjective determines the function of the construction, leading to many parallels in usage between the PA and PAN constructions. A comparison with predicate nominal constructions (PN), in contrast, shows that not including an adjective in the constructions leads to a different set of meanings and implications. The conversational usage of these constructions provides evidence for a partial correspondence of form to function: Copular Predicate Constructions often constitute a complete turn in conversation, and if not a full turn, form their own prosodic units. Other properties of these constructions—the definiteness of the NP and the presence or absence of a N—correspond to different interactional work. A comparison of all three constructions shows that the adjective plays a determining interactional role, despite differences in syntactic configuration.
Study Abroad in Sweden: Japanese Exchange Students’ Perspectives of Language Use in University EMI Courses
Authors: Siegel Aki
Published: December 2021

With the availability of English as a Medium of Instruction (EMI) courses, an increasing number of international students have been joining Swedish universities. However, the language use in Swedish EMI courses may display unique features; while many Swedish students have high English language proficiency, code-switching between Swedish and English is reported as a common practice by both lecturers and students, even when international students are present. Moreover, the term “international students” is often used to include students of various statuses and linguistic abilities, and the experiences and perspectives of short-term exchange students towards the language use in Swedish EMI courses are rarely documented. The current study investigates the perspectives of short-term exchange students from Japan enrolled in EMI courses at a university in Sweden. Questionnaire and focus group interview confirmed previous studies regarding the language-use practices in the classrooms. Moreover, the rate of speech, turn-taking, and background knowledge were found to hinder the learning and participation of the exchange students. The findings suggest the need to raise awareness of the language practices in Swedish EMI courses to students, lecturers, and other universities in order to support the learning experience of short-term exchange students.
Recurrent Implantation Failure—Is It the Egg or the Chicken?
Authors: Pirtea Paul , de Ziegler Dominique , Ayoubi Jean Marc
Published: December 2021

Recurrent implantation failure (RIF) is an undefined, quite often, clinical phenomenon that can result from the repeated failure of embryo transfers to obtain a viable pregnancy. Careful clinical evaluation prior to assisted reproduction can uncover various treatable causes, including endocrine dysfunction, fibroid(s), polyp(s), adhesions, uterine malformations. Despite the fact that it is often encountered and has a critical role in Assisted Reproductive Technique (ART) and human reproduction, RIF’s do not yet have an agreed-on definition, and its etiologic factors have not been entirely determined. ART is a complex treatment with a variable percentage of success among patients and care providers. ART depends on several factors that are not always known and probably not always the same. When confronted with repeated ART failure, medical care providers should try to determine whether the cause is an embryo or endometrium related. One of the most common causes of pregnancy failure is aneuploidy. Therefore, it is likely that this represents a common cause of RIF. Other RIF potential causes include immune and endometrial factors; however, with a very poorly defined role. Recent data indicate that the possible endometrial causes of RIF are very rare, thereby throwing into doubt all endometrial receptivity assays. All recent reports indicate that the true origin of RIF is probably due to the “egg”.
Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression
Authors: Thomas MacGregor , Savitz Jonathan , Zhang Ye , Burrows Kaiping , Smith Ryan , Figueroa-Hall Leandra , Kuplicki Rayus , Khalsa Sahib S. , Taki Yasuyuki , Teague Tracy Kent , Irwin Michael R. , Yeh Fang-Cheng , Paulus Martin P. , Zheng Haixia ,   on behalf of Tulsa 1000 Investigators
Published: December 2021

(1) Background: Growing evidence indicates that inflammation can induce neural circuit dysfunction and plays a vital role in the pathogenesis of major depressive disorder (MDD). Nevertheless, whether inflammation affects the integrity of white matter pathways is only beginning to be explored. (2) Methods: We computed quantitative anisotropy (QA) from diffusion magnetic resonance imaging as an index of white matter integrity and regressed QA on C-reactive protein (CRP), controlling for age, sex, and BMI, in 176 participants with MDD. (3) Results: The QA values of several white matter tracts were negatively correlated with CRP concentration (standardized beta coefficient = −0.22, 95%CI = −0.38–−0.06, FDR < 0.05). These tracts included the bilateral cortico-striatal tracts, thalamic radiations, inferior longitudinal fasciculi, corpus callosum (the forceps minor portion and the tapetum portion), cingulum bundles, and the left superior longitudinal fasciculus III. Importantly, the association remained robust after regressing up to twelve potential confounders. The bilateral fornix and a small portion of the thalamic radiation showed a positive association with CRP levels, but these associations did not remain significant after adjusting for confounders. (4) Conclusions: Peripheral inflammation may contribute to the etiology of MDD by impacting the microstructural integrity of brain corticolimbic white matter pathways.
Mechanical and Tribological Properties of Polytetrafluoroethylene Composites Modified by Carbon Fibers and Zeolite
Authors: Struchkova Tatyana S. , Vasilev Andrey P. , Okhlopkova Aitalina A. , Danilova Sakhayana N. , Alekseev Aleksey G.
Published: December 2021

Currently, lightweight and high-strength polymer composites can provide weight savings in the automotive and process equipment industries by replacing metal parts. Polytetrafluoroethylene and polymer composites based on it are used in various tribological applications due to their excellent antifriction properties and thermal stability. This article examines the effect of combined fillers (carbon fibers and zeolite) on the mechanical, tribological properties, and structure of polytetrafluoroethylene. It is shown that the introduction of combined fillers into polytetrafluoroethylene retains the tensile strength and elongation at break at a content of 1–5 wt.% of carbon fibers, the compressive stress increased by 53%, and the yield stress increased by 45% relative to the initial polymer. The wear resistance of polymer composites increased 810-fold compared to the initial polytetrafluoroethylene while maintaining a low coefficient of friction. The structural features of polymer composites are characterized by X-ray diffraction analysis, infrared spectroscopy, and scanning electron microscopy.
Influence of Mn, Fe, Co, and Cu Doping on the Photoelectric Properties of 1T HfS2 Crystals
Authors: Lin Der-Yuh , Shih Yu-Tai , Tseng Wei-Chan , Lin Chia-Feng , Chen Hone-Zern
Published: December 2021

Doping plays a vital role in the application of transition-metal dichalcogenides (TMDCs) because it can increase the functionality of TMDCs by tuning their native characteristics. In this study, the influence of Mn, Fe, Co, and Cu doping on the photoelectric properties of HfS2 was investigated. Pristine, Mn-, Fe-, Co-, and Cu-doped HfS2 crystals were grown using the chemical vapor transport method. Scanning electron microscopy images showed that the crystals were layered and transmission electron microscopy, X-ray diffraction, and Raman spectroscopy measurements confirmed that the crystals were in the 1T-phase with a CdI2-like structure. The bandgap of pristine HfS2 obtained from the absorption and photoconductivity spectra was approximately 1.99 eV. As the dopant changed from Mn, Fe, and Co, to Cu, the bandgap gradually increased. The activation energies of the samples were determined using temperature-dependent current-voltage curves. After doping, the activation energy decreased, and the Co-doped HfS2 exhibited the smallest activation energy. Time-resolved photoresponse measurements showed that doping improved the response of HfS2 to light; the Co-doped HfS2 exhibited the best response. The photoresponsivity of HfS2 as a function of the laser power and bias voltage was measured. After doping, the photoresponsivity increased markedly; the Co-doped HfS2 exhibited the highest photoresponsivity. All the experimental results indicated that doping with Mn, Fe, Co, and Cu significantly improved the photoresponsive performance of HfS2, of which Co-doped HfS2 had the best performance.
Graphene-Reinforced Carbon-Bonded Coarse-Grained Refractories
Authors: Storti Enrico , Fruhstorfer Jens , Luchini Bruno , Jiříčková Adéla , Jankovský Ondřej , Aneziris Christos Georgios
Published: December 2021

Carbon-bonded alumina refractories offer excellent thermal shock performance but are lacking in terms of mechanical strength. In the present contribution, the influence of the particle packing and the addition of graphene oxide (GO) to carbon-bonded alumina refractories on the physical and mechanical properties before and after thermal shock was investigated. Coarse tabular alumina grains were coated by a GO suspension and used to prepare dry-pressed compacts. The included graphite fraction (15 wt%) was either regarded as a lubricating matrix component or as a quasi-spherical component of a calculated density-optimized aggregate size distribution. During coking, the GO was reduced to thermally reduced graphene. The porosity, true density and thermal shock behavior in terms of the cold modulus of rupture (CMOR) and Young’s modulus were compared. Samples with a higher density were obtained when the irregularly shaped graphite was considered as the matrix component (lubricant). The results showed that the use of GO had a positive impact on the mechanical properties of the graphene-reinforced Al2O3–C refractories, especially in the case of a less optimized packing, due to the bridging of delamination gaps. In addition, the thermal shock only had a minor impact on the Young’s modulus and CMOR values of the samples. SEM investigation revealed very similar microstructures in coked as well as thermally shocked samples.