bluuebunny/crossref_metadata_2025 huggingface dataset:
Peering into the Black Box: Forward Modeling of the Uncertainty Budget of High-resolution Spectroscopy of Exoplanet Atmospheres
Authors: Savel Arjun B. , Bedell Megan , Kempton Eliza M.-R. , Smith Peter C. B. , Bean Jacob L. , Zhao Lily L. , Wong Kaze W. K. , Sanchez Jorge A. , Line Michael R.
Published: February 2025

Ground-based high-resolution cross-correlation spectroscopy (HRCCS; R ≳ 15,000) is a powerful complement to space-based studies of exoplanet atmospheres. By resolving individual spectral lines, HRCCS can precisely measure chemical abundance ratios, directly constrain atmospheric dynamics, and robustly probe multidimensional physics. But the subtleties of HRCCS data sets—e.g., the lack of exoplanetary spectra visible by eye and the statistically complex process of telluric removal—can make interpreting them difficult. In this work, we seek to clarify the uncertainty budget of HRCCS with a forward-modeling approach. We present an HRCCS observation simulator, scope,5

5

https://github.com/arjunsavel/scope

that incorporates spectral contributions from the exoplanet, star, tellurics, and instrument. This tool allows us to control the underlying data set, enabling controlled experimentation with complex HRCCS methods. Simulating a fiducial hot Jupiter data set (WASP-77Ab emission with IGRINS), we first confirm via multiple tests that the commonly used principal component analysis does not bias the planetary signal when few components are used. Furthermore, we demonstrate that mildly varying tellurics and moderate wavelength solution errors induce only mild decreases in HRCCS detection significance. However, limiting-case, strongly varying tellurics can bias the retrieved velocities and gas abundances. Additionally, in the low signal-to-noise ratio limit, constraints on gas abundances become highly non-Gaussian. Our investigation of the uncertainties and potential biases inherent in HRCCS data analysis enables greater confidence in scientific results from this maturing method.
A long-term ecological research data set from the marine genetic monitoring programme ARMS-MBON 2020-2021
Authors: Pagnier Justine , Allcock Louise , Cancio Ibon , Chatzinikolaou Eva , Chatzigeorgiou Giorgos , Chrismas Nathan , Costantini Federica , Dailianis Thanos , Deneudt Klaas , Díaz de Cerio Oihane , Digenis Markos , Exter Katrina , Gerovasileiou Vasilis , González Fernández Jose , Kauppi Laura , Keklikoglou Kleoniki , Kristoffersen Jon Bent , Lagaisse Rune , Mavrič Borut , Mortelmans Jonas , Paredes Estefania , Pavloudi Christina , Piazza Alessandro , Power Anne Marie , Ramšak Andreja , Santi Ioulia , Solbakken Jostein , Stavroulaki Melanthia , Stæhr Peter , Tajadura Javier , Souza Troncoso Jesus , Vasileiadou Katerina , Vernadou Emmanouela , Obst Matthias
Published: February 2025

Continuing the international efforts of the ARMS Marine Biodiversity Observation Network (ARMS-MBON), we present data from the second sampling campaign, coming from 56 Autonomous Reef Monitoring Structures (ARMS) deployed in 2020 and 2021 along European coasts under the European Marine Omics Biodiversity Observation Network (EMO BON). The data set includes information on sampling locations and conditions, sample archiving, and quality reports of collected samples. Data and metadata are openly accessible and can be downloaded from the associated GitHub repository. Sequence data can be accessed via the European Nucleotide Archive (ENA) through the corresponding accession numbers. Images of ARMS plates are stored in PlutoF and can be downloaded through links provided in this paper. Sequence data was processed and explored with the PEMA pipeline, resulting in 17,194, 7,235 and 5,261 unique ASVs/OTUs for COI, 18S and ITS, respectively. In this data set, ARMS revealed the presence of over 61 eukaryotic phyla, aligning with our previous sampling campaign. Among these phyla, 35 had ASVs/OTUs identified to the species level. With this data set and its associated paper, we provide a standardised resource for marine biodiversity monitoring and scientific analyses of benthic biodiversity. The presented data product supports future studies on the status and changes in species composition, distribution, and genetic diversity.
DNA barcoding, integrative taxonomy, citizen science, and Bush Blitz surveys combine to reveal 34 new species of Apanteles (Hymenoptera, Braconidae, Microgastrinae) in Australia
Authors: Slater-Baker Mollie-Rosae , Fagan-Jeffries Erinn P. , Oestmann Katherine J. , Portmann Olivia G. , Bament Tiahni M. , Howe Andy G. , Guzik Michelle T. , Bradford Tessa M. , McClelland Alana R. , Woodward Alice , Clarke Sylvia , Ducker Nathan , Fernández-Triana José
Published: February 2025

Microgastrinae is a megadiverse subfamily of wasps in the family Braconidae. As parasitoids of caterpillars, members of the subfamily play important roles in regulating native caterpillar populations, and several species are used commercially as biological control agents. The genus Apanteles comprises a large portion of total microgastrine diversity, however it has not been studied in Australia for more than 30 years, with only nine described species previously known from the continent. We explore the diversity and systematics of Apanteles in Australia, using cytochrome c oxidase subunit I (COI) and Wingless (wg) DNA barcodes from more than 400 Australian Apanteles specimens. Using molecular species delimitation in combination with reduced morphological diagnoses, at least 48 distinct molecular lineages of Apanteles are confirmed in Australia, and 34 new species are formally described, all authored by Slater-Baker, Fagan-Jeffries, Fernández-Triana, Portmann & Oestmann: A. adustus, A. aeternus, A. alatomicans, A. allapsus, A. amicalis, A. apollo, A. apricus, A. artemis, A. aurantius, A. auroralis, A. banrock, A. breviflagellarius, A. brockhedgesi, A. cuprum, A. darthvaderi, A. doreenwatlerae, A. ethanbeaveri, A. fenestrinus, A. ferripulvis, A. focusalis, A. hades, A. insulanus, A. kelpiellus, A. lamingtonensis, A. ligdus, A. magicus, A. margaritarius, A. pellucidus, A. phantasmatus, A. pharusalis, A. ramsaris, A. rufiterra, A. sinusulus, and A. translucentis.
Marqueurs non invasifs de stéatopathie métabolique
Authors: Castera Laurent , Peoc’h Katell
Published: February 2025

La stéatopathie métabolique (ou nonalcoholic fatty liver disease NAFLD) affecte environ un quart de la population générale et représente désormais la principale cause de maladie chronique du foie en Occident. La stéatohépatite non alcoolique ou NASH, qui constitue la forme active de la NAFLD, est définie par l’association à la stéatose, de lésions de ballonisation hépatocytaire et d’inflammation lobulaire. Les deux enjeux diagnostiques majeurs chez les patients atteints de stéatopathie métabolique sont la différenciation entre une NASH et une stéatose isolée bénigne et l’identification d’une fibrose hépatique sévère ou d’une cirrhose (stades F3F4). Les avantages des biomarqueurs sanguins comprennent leur applicabilité élevée (> 95 %), leur bonne reproductibilité inter-laboratoire et leur large disponibilité. En revanche, aucun marqueur n’est vraiment spécifique de la NASH ou de la fibrose. Concernant l’identification des patients avec une fibrose hépatique sévère ou une cirrhose, les scores les mieux validés sont le FIB-4 et le NFS ( NAFLD Fibrosis Score ), avec des AUROC ( Area under Receiver Operating Characteristic ) aux alentours 0,82 et des valeurs prédictives négatives supérieures à 90 %.
La cryptosporidiose et son impact en santé publique
Authors: Benamrouz S. , Sawant M. , Chabé M. , Guyot K. , Costa D. , Favennec L. , Gargala G. , Viscogliosi E. , Gecer Tanja
Published: February 2025

Cryptosporidium est une cause majeure de diarrhée à travers le monde et l’infection par ce parasite touche en particulier les jeunes enfants et les patients immunodéprimés. La gravité de l’infection intestinale induite par ce protozoaire intracellulaire est variable et les symptômes cliniques de la cryptosporidiose dépendent non seulement de l’état nutritionnel et immunitaire de l’hôte mais également des facteurs de virulence du parasite. L’infection humaine résulte d’une propagation zoonotique (de l’animal à l’Homme) ou anthroponotique (inter-humaine) du parasite dont la transmission est facilitée par sa résistance aux nombreux désinfectants couramment utilisés. Les mesures de prévention et de contrôle de l’infection sont capitales pour la protection des groupes vulnérables car les options de traitement restent encore limitées.
Qu’attend le médecin généraliste de la prescription des examens biologiques ?
Authors: Ourabah Rissane
Published: February 2025

Les examens biologiques sont largement prescrits par le médecin généraliste, classiquement dans le but d’établir un diagnostic ou de surveiller une pathologie connue. La prise en charge d’un patient en médecine générale est rarement ponctuelle ; elle s’étend le plus souvent sur une longue période de sa vie. Ainsi, depuis le moment précédant l’apparition d’une maladie, son diagnostic, sa prise en charge et son suivi, la prescription des examens biologiques doit répondre à chacun de ces moments et à chacune de ces circonstances. Le prescripteur attend pour chacun d’eux une réponse du biologiste adaptée à la circonstance de la prescription.
Del campo al plato: prácticas alimentarias y resistencia indígena en Colombia
Authors: Laurent Virginie
Published: February 2025

En Colombia, los años 1970 marcaron el inicio de una lucha llevada por los pueblos indígenas para reivindicar su acceso a la tierra y la protección de sus modos de vida dentro de sus territorios colectivos. Dos décadas después, la constitución adoptada en 1991 reconoció el carácter pluriétnico y multicultural de la nación. Dentro de este contexto, la comida autóctona cumple una significativa función social y política, tanto desde los alimentos que la componen, como a través de la manera en la que se comparte dentro, pero también fuera, de las comunidades indígenas. Partiendo de una perspectiva etnográfica, este artículo se enfoca en cómo las prácticas alimentarias de los pueblos indígenas han servido como palanca de su resistencia en Colombia. En especial, examina la forma en la que, simbólica y materialmente, se expresa este vínculo “del campo al plato”.
Cash Is Not King
Authors: Benest Serge
Published: February 2025

Created in 1947 as the Sixth Section of the École pratique des hautes études (EPHE), the École des hautes études en sciences sociales (EHESS) is usually recognized as the institutional stronghold of the Annales historians. Yet, new archival investigations indicate that the Section was initially conceived as a training place for economists for postwar reconstruction and, making economics central to its initial agenda. By both following the money trail, examining the scientific research agenda of the Sixth Section, this article endeavors to demonstrate the initial prominence of economics and to explain its subsequent decline within the Section. It unpacks how the Section’s funders sought to reshape the identity of academic economists by reorienting them toward practical expertise, whereas the Section’s economists resisted this patronage aim, uninterested in assuming the role of experts.
Glocalization Strategies in the Food Industry
Authors: Ali Umar Farouq , Santos Vasco
Published: February 2025

In an increasingly globalized world, multinational food enterprises (MNFEs) face the challenge of balancing standardization with local adaptation. This study explores glocalization in the food industry, focusing on strategies employed by MNFEs to succeed in diverse markets. Glocalization combines “global” and “local,” emphasizing the need for both universal and particular strategies. The research examines the marketing mix (4Ps: Product, Price, Place, Promotion) in this context. Product localization involves adapting menus to local tastes, while pricing considers local economic conditions. Place strategies focus on distribution channels tailored to local habits, and promotional efforts require cultural sensitivity. Brand perception and consumer behaviour are crucial for success. The study highlights the importance of respecting local culture in offerings and marketing. Successful glocalization requires a deep understanding of local markets and flexible strategies, enabling MNFEs to build strong brand perceptions and achieve sustainable growth in diverse international markets.
Performing Skills in the Tourism Industry
Authors: Santos Vasco , Sousa Bruno Barbosa , Peres Rita , Bacalhau Lara , Reis Isabel , Sampaio Marta Correia , Martinho Filipa , Marcão Ricardo
Published: February 2025

This study examines key competencies in tourism, highlighting the balanced value of technical (hard) and interpersonal (soft) skills. In tourism, where customer interaction and cultural sensitivity are paramount, a multidimensional skill set enhances employability and organizational competitiveness. Findings show that technical skills, such as operational and financial expertise, are essential for efficiency yet insufficient alone to meet complex industry needs. Soft skills—communication, adaptability, teamwork, and problem-solving—are critical for customer satisfaction and positive client experiences. Moreover, competencies like emotional intelligence and leadership are vital in multicultural settings. The study suggests educational programs should integrate both skill types to better align with industry demands. This competency-based approach benefits not only tourism but also broader workforce development, promoting sustainable growth through adaptable, well-rounded professionals.
Sustainability Organizational Reporting and Corporate Citizenship
Authors: Vargas-Hernandez José G. , Gonzàlez-Àvila Francisco J. , Vargas-Gonzàlez Omar C.
Published: February 2025

This study aims to analyze some of the issues of organizational sustainability reporting and its interrelations with corporate citizenship. It departs from the assumption that appropriate research for organizational sustainability reporting contributes to the management governance leading to face the challenges of sustainability collaboration, innovation and sense making required by the development of a corporate citizenship. The method employed is the meta-analytic and meta-cognitive, reflective and descriptive based on the literature review of the issues on sustainability management governance. It is concluded that the issues of organizational sustainability reporting enhance the corporate citizenship of firms
Exploring the efficacy of AMACR, ERG, and AR immunostains in prostatic adenocarcinoma and their association with novel grade groups
Authors: Andarawi Mohamed O. , Otifi Hassan , Hassan Hesham , Yousif Adil A. , Mustafa Saadalnour A. , Elsiddig Shawgi A. , Babker Asad Ma , Ali Elryah I. , Elhag Omer Osman
Published: February 2025

The study examines the utility of AMACR, ERG, and AR immunostains in diagnosing prostatic adenocarcinoma (PCa) and assessing prognosis in comparison to the Gleason score and new WHO grading groups. Seventeen PCa biopsies and five benign prostatic hyperplasia (BPH) biopsies were analyzed. Immunoreactivity, scored from 1 to 3 based on percentage of positive cells and intensity of expression, was assessed, revealing 76.47% positivity for AMACR, 35.29% for ERG, and 94.12% for AR in PCa cases, with variable scores and intensity among markers and grade groups. AMACR sensitivity and ERG specificity were noted. Higher-grade PCa exhibited increased positivity for both markers, indicating prognostic significance. In BPH cases, AMACR showed positivity in 2 cases, ERG in 1, and AR in all cases, albeit with lower expression. Differential expression was observed among immunomarkers and grade groups of malignancy. AMACR and ERG stains serve as sensitive and specific markers for PCa diagnosis and prognosis. Their increasing positivity with higher-grade groups underscores prognostic value. These findings highlight the importance of immunostains in refining PCa diagnosis and prognostication.
Challenges in diagnosis and treatment of cushing disease in a 12-year-old boy. Case report
Authors: Gjikopulli Agim , Tomori Sonila , Tanka Marjeta , Bali Donjeta
Published: February 2025

Cushing’s Disease (CD), defined as hypercortisolism caused by excess Adrenocorticotropic Hormone (ACTH) secretion by a pituitary corticotroph adenoma, rarely presents in the pediatric age range. The aim is to describe a 12-year-old Albanian boy with a challenging pathway to diagnosis and treatment process for Cushing's disease. He presented with headaches, rapid weight gain during the last three years, stunting, increased body hair growth, and a typical Cushingoid appearance. After a consultation in the Pediatric Endocrinology Unit at the University Hospital Center, “Mother Teresa,” in Tirana, the boy was pre-diagnosed with Cushing Syndrome, and hypophyseal adenoma was suspected due to suggestive laboratory tests, although non-consistent imaging results. An ectopic ACTH-dependent Cushing syndrome was suspected together with neuroendocrine neoplasia (carcinoid tumor) as a thoracic CT showed a nodular lesion with regular-lobulated sharp contours in the lower lobe of the right lobe resulted in pulmonary tuberculosis granuloma. Even imaging failed to identify the ACTHsecreting microadenoma; the decisive examination was an intervention to collect samples from the inferior petrosal sinus during the CRH test, which found a left-side ACTH-secreting focus. Left hemi-hypophysectomy was performed using gamma knife therapy, resulting in effective normalization of hypercortisolism, but with the side effect of growth hormone deficiency.
Towards an approach for enhancing water security: The case of South Africa
Authors: Mokone Neo W. , Gumede Vusi
Published: February 2025

Background: Water demands in South Africa are rising, yet there is a lack of frameworks addressing sustainable water security at the local level. This gap, compounded by limited empirical evidence, challenges efforts to enhance water security.Aim: The article assesses water security and proposes a localised and adaptive framework for long-term water security at the household level in South Africa, aligning with sustainable development and integrated water resource management principles.Methods: Fieldwork, based on mixed methods approach, was conducted and a review of relevant literature was undertaken to identify fundamental dimensions of water security.Results: Critical elements influencing water security (viz. grouped into five dimensions: economic, social, technical, environmental, and institutional) were observed. An approach, based on the critical elements pertaining to water security, was developed to address the relevant dimensions, offering an integrated approach to enhancing water security.Conclusion: The proposed framework advances an understanding of water security by offering a novel and actionable approach that can be adapted to local contexts in South Africa (and possibly in other countries too). It emphasises the importance of multi-dimensional solutions to enhance the resilience of local water supply systems.Contribution: This article fills a significant gap in local-level water security frameworks, providing a practical model for policymakers and stakeholders to implement sustainable water security strategies in South Africa.
Reproducibility Issues in Cancer Research: A Compendious Study
Authors: Bhar Sunandita , Kabi Bikash , Kar Kanisha , Das Tanima , Ghosh Diya , Chandra Arpita
Published: February 2025

Scientific advances depend on the robust and reliable knowledge that serves as a solid foundation for further development. Currently, we are in the arena of unprecedented scientific publications in the field of cancer biology. However, unfortunately, the inability to reproduce the findings has been a long-standing problem and is a matter of serious concern. Compelling evidence suggests that, this irreproducibility of basic and preclinical research is mostly a result of the failure of good scientific practice by multi-stakeholders. It is high time to endorse a multipronged approach to address this concern. In this review, we have discussed the burning problems related to the reproducibility of findings in cancer research. Since, no single solution will suffice, herein we tried to put forth some of the probable approaches that may help to improve research qualities as well as reproducibility.
Glucocorticoid Receptor Interacts with B-cell Lymphoma 2 for Domineering Aggressiveness of Breast Cancer: An Observational Study
Authors: Thakur Debanjan , Kar Shinjini , Sengupta Debomita , Chakrabarti Jayanta , Sen Sagar , Roy Arindam , Mahapatra Elizabeth , Das Salini , Mukherjee Sutapa
Published: February 2025

Background:

Steroid hormone receptors (HRs) such as estrogen receptor/progesterone receptor are routinely used for stratifying breast cancer (BC) patients during endocrine-targeted therapy, except triple-negative BCs which lack these receptors. Thus, probing for alternative steroid HRs with prognostic value in BC is necessary. Glucocorticoid receptor (GR), another steroid HR, associated with prosurvival has been known to be prognostic in breast carcinoma, although studies in the Indian patients’ cohort are scanty. Antiapoptotic protein B-cell lymphoma 2, (Bcl-2) being positively associated with GR, is also known to have a significant influence on BC progression, but its exact role is paradoxical.

Aim and Objective:

This study aimed to look into the expressional status of GR in the Indian BC patients’ cohort to understand the molecular basis of its association with Bcl-2 to provide a basis for the prognostic value of Bcl-2 and its impact on clinicopathological parameters related to disease progression. This study was conducted in the BC patient cohort (n = 15) of all molecular subtypes visiting hospital outpatient department.

Materials and Methods:

In silico data mining, flow cytometry, enzyme-linked immunosorbent assay, immunoblotting, and co-immunoprecipitation were performed to analyze for subsequent observations. Pearson correlation analysis and Chi-squared tests were performed to derive the statistically relevant findings.

Results:

GR is co-expressed with Bcl-2 in the concerned cohort, and participates in protein-protein interactions subsequently sustaining its expression and supplementing to aggressiveness of the disease.

Conclusion:

GR/Bcl-2 interaction in preliminary findings demanded further extensive research to establish GR and Bcl-2 as promising targets in BC.
Targeting Cancer Stem Cells by Natural Compounds in Combination with Conventional Chemotherapy: An Ideal Strategy for Combating Cancer Recurrence
Authors: Ghosh Rituparna , Biswas Souradeep , Samanta Priya , Sarkar Rupali , Pakhira Shampa , Mondal Mrinmoyee , Bhowmik Arijit , Hajra Subhadip , Saha Prosenjit
Published: February 2025

Conventional chemotherapy, one of the foremost types of cancer treatment, usually displays satisfactory efficacy in the initial stages. However, lots of patients suffer from drug resistance as well as cancer relapse which are two major hindrances in cancer treatment. The main culprit behind these two barriers is cancer stem cells (CSCs). CSCs, a small subpopulation within the tumor, have self-renewal properties. Besides, this population is responsible for metastasis, angiogenesis, and other hallmarks of cancer. CSCs are able to escape the drug insults provided by synthetic conventional therapeutics. On the other hand, natural compounds are showing enough potential to eradicate CSCs in tumors. Along with this, the combination of natural and synthetic compounds has more efficacies to control both proliferating cancer cells as well as CSCs. These therapeutic combinations significantly downregulate various CSC markers and molecular pathways that play crucial roles in the enrichment of CSCs in vitro and in vivo. In this review, we provide brief descriptions about some natural compounds which are potent CSC-targeting agents when used as monotherapy or combinatorial therapy. This review focuses on the combinatorial therapy of natural and synthetic compounds which can provide new therapeutics for cancer treatment in near future.
The Role of Parental Depression on Adolescent Depression in Indonesia
Authors: Mubasyiroh Rofingatul , Suryaputri Indri Yunita , Putri Alifa Syamantha , Setiyawati Diana , Irmansyah  , Suparmi  , Sulistiyowati Ning , Lasut Doni , Oktarina
Published: February 2025

Introduction:

Depression is one form of common mental disorder that significantly impacts adolescents. The emotional well-being of parents and family can directly influence adolescents’ mental states. This study aimed to assess the association between parental depression and adolescents aged 15–19 years.

Methods:

This study utilized data from the third, fourth, and fifth cycles of the Indonesian Family Life Survey (IFLS) conducted jointly by Research and Development Corporation and Universitas Gadjah Mada. Adolescent depression was assessed using the Center for Epidemiologic Studies Depression-10, in which IFLS-5 (2014) data were analyzed. At the same time, parental depression was measured using data from IFLS-4 (2007) and IFLS-5 (2014). The study sample consisted of adolescents living with their parents, and 1104 adolescents were involved in the analysis. A multivariate logistic regression model of potentially contributing factors was employed to analyze the role of parental depression in adolescent depression.

Results:

A substantial portion of adolescents (21.2%) reported experiencing depression, with a higher prevalence observed among girls (25.3%). Adolescents were more likely to experience depression if their parents also reported depressive symptoms. According to 2014 data, as many as 25.4% of adolescents with mothers experiencing depression also reported feeling depressed. Meanwhile, 28.1% of adolescents experienced depression at the same time that their fathers felt depressed. Parental depression affected adolescent depression and had a significant and greater effect on female adolescents.

Conclusion:

This study revealed a strong association between parental depression and adolescent depression in Indonesia. The results underscore the importance of family-based interventions to reduce the adverse effects of depression on adolescents.
Effect of Nitazoxanide and Probiotic Treatment on Bangladeshi Children with Cryptosporidiosis
Authors: Noor Zannatun , Hossain Biplob , Mithila Nishad Tasnim , Khatun Amena , Mahmud Sultan , Ferdous Aleya , Akhter Bipasha , Alam Masud , Gilchrist Carol A. , Haque Rashidul , Petri William A.
Published: February 2025

Cryptosporidium spp. is a cause of diarrhea morbidity and mortality in children under 5 years of age. In addition, asymptomatic infections can have a negative impact on growth and development. In low- and middle-income countries where a greater number of infants may be malnourished, the results of treating cryptosporidiosis with the only Food and Drug Administration-approved drug nitazoxanide (NTZ) have been inconsistent. Malnutrition is both a risk factor for cryptosporidiosis and a consequence of infection with this parasite. Treatment with the probiotic Lactobacillus reuteri DSM 17938 has been shown to assist in nutritional recovery and the restoration of gut health. In this pilot randomized clinical trial, we examined whether combined probiotic and NTZ treatment could result in the reduction in parasitemia and infection-associated growth stunting in undernourished children. Cryptosporidium spp.-positive Bangladeshi children with a weight-for-length Z score between −1 and −3 were randomly assigned to one of three groups. Group 1 (n = 26) received NTZ and Lactobacillus, group 2 (n = 28) received NTZ along with a placebo, and the third control group (n = 10) received standard care. There was no difference in the duration of infection or improvement in child anthropometric measurements in any treatment group compared with control. Therefore, this pilot study does not provide support for treatment with NTZ, Lactobacillus, or the two in combination as an effective means of reducing the duration of Cryptosporidium spp. infection or improving growth in growth-stunted children.
Prognostic Models in Patients with Dengue: A Systematic Review
Authors: Diaz-Arocutipa Carlos , Chumbiauca María , Soto-Becerra Percy
Published: February 2025

There is uncertainty regarding the usefulness of predictive models for dengue prognosis. We performed a systematic review to identify and evaluate prognostic models in patients with dengue. We conducted a literature search in PubMed, Embase, and Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) up to May 24, 2023. We included case–control and cohort studies that developed or validated multivariable prognostic models related to severity, hospitalization, intensive care unit (ICU) admission, or mortality in patients of any age with a laboratory-based diagnosis of dengue. A narrative synthesis of the performance measures of the prognostic models evaluated in each study was performed. Of the 4,211 articles, a total of 35 studies reporting information on 43 prognostic models were included. Among these, 35 were developmental and 8 were for external validation. Most models were designed to predict severity (n = 30), followed by mortality (n = 10), hospitalization (n = 2), and ICU admission (n = 1). The reported C-statistic in the models ranged from 0.70 to 0.95 for severity, 0.83 to 0.99 for mortality, 0.87 for hospitalization, and 0.92 for ICU admission. Calibration measures were poorly reported in the vast majority of models. According to the Prediction Study Risk of Bias Assessment Tool, the risk of bias was considered high for all included models, and applicability was of low concern for most models. Our study identified multiple prognostic models, particularly for predicting severity and mortality in patients with dengue. Although most models demonstrated acceptable discriminative ability, calibration measures were poorly reported, and the overall methodological design was poor.
PDE4 inhibition and enhancement of human memory and cognition
Authors: Bolger Graeme B.
Published: February 2025

Activation of the adenylyl cyclase – PKA – CREB signaling pathway has been shown to be critical for learning and the creation and consolidation of memory. The PDE4, or cAMP-specific, phosphodiesterases (PDEs) are important modulators of cAMP levels in the central nervous system. The establishment of the essential role of PDE4 isoforms in learning and memory has been based on a long-standing interplay between experiments in genetically-tractable organisms, such as flies and mice, and pharmacological studies in rodents, primates and humans. Collectively, these diverse approaches have demonstrated the pivotal role of PDE4s in learning and memory and that pharmacological targeting of PDE4s can enhance learning, memory and cognition in humans. However, several challenges remain before PDE4 inhibitors can be used clinically in disorders of cognition and memory. Current priorities in PDE4 drug discovery focused on the CNS include 1) further refinement of isoform selectivity; 2) more precise action at CNS targets implicated in cognition and memory, such as those in forebrain and hippocampus, while reducing undesired action at other CNS (area postrema) and non-CNS targets (CFTR, gastric acid secretion) that account for the limiting side effects of many, but not all, PDE4 inhibitors in clinical trials; and 3) improved pharmacokinetics and dosing.
Insights into early acne pathogenesis: Exploring intercellular dynamics and key dysregulated genes
Authors: Deng Min , Farahani Kiana , Agak George W.
Published: February 2025

An investigation of comprehensive changes and shared dysregulated signaling pathways across acne patients in the early stages remains largely unexplored. In our recently published paper entitled “Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin,” we utilized single-cell RNA sequencing and spatial RNA-seq datasets from acne patients to analyze cell communication. We identified dysregulated genes associated with inflammatory responses and hyperkeratinization. This commentary discusses new potential markers in major skin cell types, including endothelial cells, fibroblasts, lymphocytes, myeloid cells, keratinocytes, and smooth muscle cells. We also discuss key dysregulated genes associated with inflammation and hyperkeratinization in acne lesions, focusing on the intricate interplay between these processes. Based on our findings, we discussed potential FDA-approved treatments targeting two key pathways involved in acne pathogenesis. These insights offer new therapeutic targets for acne treatment.
Cable cars to the nucleus: TM4SF1-enriched microdomains and cell signaling
Authors: Jaminet Shou-Ching
Published: February 2025

Proliferating cells with volumes of 2,000–4,000 μm3 contain about ten billion protein molecules, making it challenging, in a crowded cellular environment filled with vesicles and organelles, for proteins to find their interaction partners and coordinate signaling. In endothelial cells, we discovered a key molecule transport pathway mediated by TM4SF1-enriched microdomains (TMED). TMED are 100-300 nm diameter proteinlipid complexes formed by clusters of TM4SF1, a small plasma membrane glycoprotein with tetraspanin topology. TMED internalize via microtubules from the cell surface toward the microtubule organizing complex and then enter the nucleus via nuclear pores (see Graphic Illustration). This internalization pathway permits direct communication of extracellular stimuli to intracellular gene expression regulation. Key molecules involved in cell proliferation and cell migration such as phospholipase C, gamma 1 (PLCγ1) and histone deacetylase 6 (HDAC6) are among the signaling proteins transported. In the absence of TMED, endothelial cells lose the ability to divide in vitro and to support blood vessel formation in vivo. We propose that TMED act like cable cars, take in passengers at the cell surface, ride along microtubule cables, and deliver their passengers to various locations including the “city center”, the nucleus. This commentary aims to illustrate this analogy through TMED in endothelial cells, to show that cells, like busy cities, need efficient transport systems to deliver passenger molecules to their proper destinations to conduct signaling.
Blasco Jover, Carolina, Cuestiones clave sobre la readmisión y los salarios de tramitación en el despido improcedente, Valencia, Tirant lo Blanch, 2024
Authors: Parres Miralles Rubén
Published: February 2025

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The Influence of Training Approaches in In-Service Teacher Training on the Implementation of the Competence-Based Curriculum in Public Primary Schools in Kilifi County, Kenya
Authors:   Department of Educational Management, Policy and Curriculum Studies, Faculty of Education, University of Nairobi, Kailo Mumbe , Njagi Lucy ,   Department of Educational Management, Policy and Curriculum Studies, Faculty of Education, University of Nairobi, Kalai Jeremiah M. ,   Department of Educational Management, Policy and Curriculum Studies, Faculty of Education, University of Nairobi, Mutegi Reuben G. ,   Department of Educational Management, Policy and Curriculum Studies, Faculty of Education, University of Nairobi
Published: February 2025

In-service teacher training plays a pivotal role in the successful implementation of the Competence-Based Curriculum (CBC) in public primary schools. As Kenya transitions to CBC, it is crucial to examine how different training approaches affect teachers’ ability to deliver and assess the new curriculum effectively. This study investigates the impact of various training methodologies on CBC implementation in Kilifi County, focusing on the prevalence and effectiveness of traditional versus innovative teaching strategies. The findings reveal a dominance of traditional teaching methods, such as group projects, discussions, and lectures, with 93.2% of respondents frequently using group projects and 89.8% employing discussions/presentations regularly. In contrast, innovative methods like gamified learning, problem-solving, and brainstorming are significantly underutilized, with 46.9%, 53.4%, and 69.7% of respondents, respectively, never using these techniques. Chi-square analysis indicates that interactive training approaches, including practical discussions and guided practice, have a substantial positive effect on instructional delivery, assessment, and professional growth, evidenced by p-values of 0.000, 0.009, and 0.003. Theoretical training with immediate feedback is significantly effective in instructional delivery and assessment (p = 0.000) but less impactful on professional development (p = 0.186). Engaging activities and mentorship are crucial for enhancing instructional delivery and assessment (p = 0.000 and p = 0.002), while adapting teaching styles and using technology show inconsistent effects. The study concludes that while traditional methods are prevalent, integrating interactive and innovative training approaches is essential for effective CBC implementation. Recommendations include prioritizing practical, hands-on training that aligns with CBC principles, promoting underutilized innovative methods, strengthening mentorship for inexperienced teachers, and emphasizing continuous professional development through seminars and workshops to improve CBC execution.
Urinary Tract Infections as a Trigger for Dementia Progression
Authors:   Assistant Professor, Department of Pharm D, CMR College of Pharmacy, Hyderabad, India Orcid id: 0009-0005-2783-9396, Lahari Samudrala
Published: February 2025

Urinary tract infections (UTIs) are one of the infections that occur most frequently among the elderly and are now increasingly recognized as a significant factor in the causation of cognitive decline, particularly among those who had previously experienced dementia. This broad review focuses on epidemiological evidence, underlying pathophysiological mechanisms, and clinical consequences for examining the complex interrelationship between UTIs and dementia. Frequent UTIs have been shown to worsen the symptoms of dementia and accelerate cognitive deterioration due to the induction of systemic inflammation, neuro-inflammation, and disturbances of the blood-brain barrier. Delayed treatment due to diagnostic difficulties in the elderly further exacerbates cognitive effects. Preventive measures associated with alleviation of UTI-related cognitive burden include early detection, efficient management of UTI, and techniques reducing inflammation. It thus emphasizes on integrating multidisciplinary approaches as an improvement pathway towards better results in this highly vulnerable population.
Management of Difficult Airway in a Patient with Oral Cavity Cancer: Case Report
Authors:   Third year anesthesiology resident. General Hospital of Cancun. Faculty of Medicine of the Autonomous University of Yucatan., Duarte Katia Leticia Mendez , Flores Ángel Gustavo Bernabe ,   Anesthesiologist and teacher at the General Hospital of Cancun., Ocampo Fernando Alberto Avelar ,   Third year resident in anesthesiology. General Hospital of Cancun. Faculty of Medicine of the Autonomous University of Yucatan.
Published: February 2025

For the anesthesiologist the management of a difficult airway is crucial to avoid serious complications that can endanger the life of a patient, so multiple strategies and tools have been developed to prevent mishaps. In this case report we present a patient with a diagnosis of inferior alveolar ridge carcinoma who presents with modifications in the head and neck anatomy, due to a history of previous surgical interventions and radiotherapy and chemotherapy treatment. The patient was scheduled to undergo surgery to take and apply a free graft in the neck, which was successfully performed with rapid sequence intubation in an awake patient. The Royal College of Anesthesia's fourth National Audit Project (NAP4) conducted a study in which it was reported that approximately 40% of patients presenting with an airway complication during anesthesia were related to head and neck tumors, so the following is an analysis of predicted difficult airway management.
Surgical Management of Lagophthalmos with Gold Pessary
Authors:   Hospital general regional número 1, Ciudad Obregón Sonora, Serrano María Guadalupe Nieblas , Cárdenas Rogelio Rodríguez ,   Hospital General Regional 46 Lázaro Cárdenas, IMSS Guadalajara Jalisco, Landeros Juan Jesús Ortega ,   Hospital Regional Lic. Adolfo López Mateos, ISSSTE, CDMX, Mejia Lucero Ramirez ,   UMAE Hospital de Especialidades Dr Bernardo Sepúlveda Gutiérrez, Centro Medico Siglo XXI, Rodríguez Jesús Alejandro Olvera ,   Clínica Hospital Constitución ISSSTE Monterrey, Nuevo León, Macklis Alvaro Sebastian Gutierrez ,   Universidad Autónoma de Baja California, Campus Ensenada, Unidad Valle Dorado., Polito Alfonso Sandoval ,   Instituto Tecnológico y de Estudios Superiores de Monterrey, Sastré Alberto Jaramillo ,   Facultad de Medicina UNAM, Aragón Wendy Melisa Gomez ,   Universidad Autónoma Benito Juárez Oaxaca, López Andrés Eduardo Martínez ,   INSTITUTO DE ESTUDIOS SUPERIORES DE CHIAPAS CAMPUS TUXTLA GUTIÉRREZ, Cesareo Luis Fernando Castillo ,   Hospital General Dr Rubén Leñero, Rojas Angeles Anahi Mendoza ,   Universidad Regional Del Sureste, Rivera Joselyn Ugalde ,   Hospital General de Querétaro
Published: February 2025

Gold weight implantation is a widely used surgical technique for managing lagophthalmos caused by facial nerve paralysis. This procedure involves placing a gold weight in the upper eyelid to facilitate passive closure, thereby protecting the cornea from exposure-related complications such as keratitis and ulceration. Advancements in implant design, such as elliptical shapes with suture holes for enhanced fixation, have reduced complications like migration, extrusion, and infection. Techniques including retrograde implantation and supratarsal fixation further improve placement accuracy and reduce postoperative morbidity.

Despite its efficacy, long-term complications such as implant migration, cosmetic concerns, ptosis, and infection may arise, highlighting the importance of careful surgical planning and patient-specific approaches. Adjunctive measures, such as fascia lata grafts, have been shown to improve implant stability and minimize the need for revision surgeries.

Gold weight implantation remains a reliable and effective solution for restoring eyelid function in patients with facial nerve paralysis, with continued refinements in techniques and materials contributing to enhanced functional and aesthetic outcomes.
Study on the Physical Conditions of Horses for Better Management of Welfare in Conditions of Climate Change in the Diourbel Region, Senegal
Authors:   ISFAR/Alioune DIOP University, BP: 54 Bambey, Senegal., KANE Ousmane , BADJI Alkaly ,   ISFAR/Alioune DIOP University, BP: 54 Bambey, Senegal., FAYE Abdoulaye ,   ISFAR/Alioune DIOP University, BP: 54 Bambey, Senegal., BADIANE Mariama ,   ISFAR/Alioune DIOP University, BP: 54 Bambey, Senegal.
Published: February 2025

OBJECTIVES: This quasi-experimental study aimed to investigate the effects of the "Application ODS" mobile app on educating one-day surgery (ODS) patients about anesthesia practices, specifically its impact on their knowledge and clinical outcomes.

METHODS: The sample consisted of 62 ODS patients at Lampang Hospital, randomly divided into experimental (n=31) and control (n=31) groups. The "Application ODS," a general information questionnaire, a knowledge assessment form, and a clinical outcome record form were utilized. Data analysis employed descriptive statistics, paired t-test, independent t-test, and chi-square test.

RESULTS: Pre-test and post-test scores the experimental group's mean knowledge score increased significantly more (11.03±0.65 to 17.83±0.73) than the control group's (10.77±0.55 to 12.55±0.77) (p<0.001). The experimental group achieved a high knowledge level and had no adverse events, with significantly lower hospital stay rates than the control group (p=0.015, p=0.019). Surgery cancellation or postponement did not differ significantly between groups.

CONCLUSIONS: The "Application ODS" effectively increased ODS patients' knowledge and improved some clinical outcomes. Widespread adoption should be promoted to enhance healthcare quality and safety for this patient group. Further app development based on user needs and larger, long-term studies are recommended to inform appropriate policies.
Corporate Strategies for Addressing Life Insurance Purchase Decisions in Ghana
Authors:   Founding Owner and Director, Trimonde Ghana Limited, Accra Ghana., Gakpo Dr. Maxwell Dela Yao , -Kyei Mame Dufie Achampong ,   Chief Executive Officer, Glico Life Insurance Company, Glico House Accra., Anafure Dr. Aaron Issa ,   Chief Executive Officer, Quality Life Insurance Company, Accra Ghana., Reichmann Dr. Richard Mensah ,   Executive Director, Moonlight Groupe, Accra, Ghana.
Published: February 2025

This study explores corporate strategies for addressing customer behaviour in purchasing life insurance coverage in Ghana, focusing on factors influencing purchase decisions, reasons for policy lapsation, and effective marketing strategies to enhance consumer engagement. This study employed a qualitative research approach, collecting data primarily through in-depth interviews. The findings revealed that income levels, guaranteed protection, and assured coverage are key drivers of life insurance purchases. Conversely, economic and social challenges such as unemployment, job loss, rising premiums, family issues, divorce, and education contribute to policy lapsation. The study highlights four strategic dimensions to positively influence consumer behaviour: adopting digital technologies, enhancing customer experiences, increasing brand visibility, and offering differentiated products. It concludes that addressing Ghana's low insurance penetration requires strategic efforts to reshape public perceptions and emphasize the societal importance of life insurance. Practical recommendations include leveraging these findings to develop targeted marketing strategies that align with consumer interests and drive higher adoption rates.
O laboratório de Educação Matemática e suas contribuições para a formação inicial de futuros professores de Matemática e para a comunidade
Authors: Toledo Neila de Toledo e , Scheller Morgana , Guimarães Caio Gomes , Guimarães Isadora
Published: February 2025

O presente trabalho tem como objetivo apresentar reflexões acerca das experiências vivenciadas no Laboratório de Educação Matemática (LEM). Os aportes teóricos que lhe dão sustentação encontram-se, principalmente, nas formulações de Jorge Larrosa eUbiratan D’Ambrósio. A metodologia proposta se estabelece em aspectos participativos e colaborativos. Desse modo, os principais procedimentos metodológicos que foram adotados: a) elaboração do Plano de Atividade para cada semestre, em conjunto com a professora coordenadores e bolsistas; b) divulgação do LEM na Gerência Regional de Educação (Gered), nas feiras regionais de matemática e nas secretarias de educação municipais da região do alto vale do Itajaí. A partir das demandas de visitas organizou-se as atividades; c) planejamento de atividades utilizando os materiais do LEM; d) construção de jogos didáticos e outros materiais com diferentes níveis de dificuldades com a preocupação constante com o conceito matemático a ser desenvolvido; e) divulgação do curso de licenciatura em Matemática e de outros cursos da instituição. Vale ressaltar que as atividades desenvolvidas no LEM contribuem para a aproximação do Instituto Federal Catarinense (IFC) da comunidade externa. Conclui-se que: a) a experiência contribuiu para a compreensão das práxis docentes na formação dos acadêmicos; b) as atividades atingiram os objetivos, pois além de integrar teoria e prática, desenvolveu competências essenciais para a docência; c) possibilitou refletir criticamente sobre cada uma das etapas realizadas, o que contribui muito para a formação dos futuros professores de matemática.