bluuebunny/crossref_metadata_2025 huggingface dataset:
Penentuan Prioritas Pilar Satuan Pendidikan Aman Bencana (SPAB) Menggunakan Metode Analytical Hierarchy Process (AHP)
Authors: Pahleviannur Muhammad Rizal
Published: March 2022

Kajian dalam buku ini bertujuan untuk mengetahui pilar pertama yang berkaitan dengan fasilitas sekolah aman, terdiri dari pemilihan lokasi aman, struktur bangunan, standar kinerja, desain aman terhadap bencana, pembangunan konstruksi, dan pemeliharaan bangunan. Pilar kedua yaitu manajemen bencana di sekolah terdiri dari persiapan, perencanaan, dan keberlanjutan, sedangkan pilar ketiga yaitu pendidikan pencegahan dan pengurangan risiko bencana terdiri dari integrasi dengan kurikulum dan pengenalan risiko bencana di sekitar sekolah. Pilar pendidikan pencegahan dan pengurangan risiko bencana kaitannya dengan integrasi kurikulum dan ekstrakulikuler menjadi hal yang penting dalam pengelolaan SPAB. Adanya peran guru dalam menyampaikan materi secara langsung maupun tidak langsung saat kegiatan belajar mengajar dapat meningkatkan pemahaman siswa mengenai mitigasi bencana, sehingga hal tersebut dapat terus dilakukan oleh guru.
METODOLOGI PENELITIAN KESEHATAN
Authors: ANJANI ARUM DWI , AULIA DEVY LESTARI NURUL , Suryanti Suryanti
Published: March 2022

Penyusunan Buku ini tentunya tidak terlepas dari bantuan, bimbingan, dorongan dan motivasi dari berbagai pihak. Untuk itu pada kesempatan kali ini kami mengucapkan terima kasih sebanyak-banyaknya kepada seluruh pihak yang telah membantu dalam penyusunan buku ini yang Insya Allah buku ini dapat bermanfaat bagi semua pihak, terutama pembaca.
ETIKA ORGANISASI PIMPINAN
Authors: Suharyat Yayat
Published: March 2022

Etika organisasi dapat diartikan sebagai tatanan moral yang digunakan oleh setiap elemen organisasi untuk mengelola dan mengembangkan organisasi. Secara umum timbul pertanyaan faktor apa saja yang dapat mempengaruhi etika organisasi. Kondisi ini dapat diidentifikasi sebagai berikut: (1) Apakah sikap terhadap entrepreneur mempunyai hubungan dengan etika organisasi? (2) Apakah kepemimpinan kharismatik mempunyai hubungan dengan etika organisasi? (3) Apakah kecerdasan emosional mempunyai hubungan dengan etika organisasi? (4) Apakah tingkat pendidikan mempunyai hubungan dengan etika organisasi? (5) Apakah pengetahuan tentang budaya organisasi mempunyai hubungan dengan etika organisasi ? (6) Apakah pola penerapan manajemen tertentu berhubungan dengan etika organisasi ? Keberadaan etika organisasi ini perlu diuji kemantapannya apabila dipengaruhi oleh status akreditasi, tingkat pendidikan pimpinan dan penerapan suatu pola manajemen tertentu karena kualitas pengembangan kinerja yang beretika sangat terkait dengan ketiga hal tersebut. Misalnya semakin buruk status akreditasi perguruan tinggi akan memberikan efek terhadap etika organisasi.
PERJANJIAN KERJASAMA DAN PELAYANAN KESEHATAN BAGI PESERTA ASURANSI KESEHATAN
Authors: IRIANTO KARTIKA DEWI
Published: March 2022

Buku ini berisi tentang Perjanjian Kerjasama antara PT.ASKES (Persero) Cabang Padang dengan RSUP DR.M.Djamil Padang tentang Pelayanan Kesehatan bagi Peserta Askes Wajib di mana Askes Wajib merupakan pelayanan yang ditujukan kepada peserta Askes Wajib yaitu Pegawai Negeri Sipil, Penerima Pensiun Sipil dan TNI- Polri, Veteran dan Perintis Kemerdekaan beserta anggota keluarga yang ditanggung. Salah satu jenis pelayanan yang diberikan oleh PT.ASKES bagi peserta Askes Wajib beserta anggota keluarga yang ditanggung seperti; rawat jalan tingkat lanjutan, rawat inap, pelayanan obat, pelayanan darah, persalinan dan gangguan kehamilan, palayanan bayi kurang dari 3 (tiga) bulan, pelayanan transfusi darah, dan pelayanan jantung.
PEMASARAN JASA
Authors: Hasan Syamsurijal , Awalia Syifa , Sihombing Nikous Soter , Hakim Irma , Juliana Juliana
Published: March 2022

Pemasaran jasa secara khusus yakni pemasaran pada produk dalam bentuk jasa atau produk tidak berfisik pada dasarnya berbeda dengan pemasaran pada produk berfisik. Perlu dipahami teknik pemasaran jasa tentu tidak hanya harus dikuasai pemilik perusahaan, namun juga karyawan. Tidak sedikit yang justru kondisinya lebih ahli karyawannya, karena karyawan akan fokus pada satu jenis tugas dan cabang tugas yang masih berhubungan. Sementara pemilik apa yang dipikirkan punya cabang lebih banyak. Agar lebih mudah dan sukses dalam memasarkan jasa, maka kenali dulu apa itu pemasaran jasa dan segala unsur maupun aspek yang mempengaruhinya.
Revisiting the Political Economy of the State to Society Relation during Mubarak Regime
Authors: Shakoor Abdul , Khan Sajjad Ali , Ahmad Tahir
Published: March 2022

This study revisits the political economy of the Mubarak Regime and his downfall byengaging with the existing literature, which dwells on political, economic,administrative, legal, and constitutional methods of maintaining hegemony and regimessurvival. This paper revisits and combines them into a single framework and argues thatstate structure and society remained fundamentally disconnected from each other,whereas their relations remained dialectical between the state's control over society onthe one hand and interests of the people on the other. It is argued that Mubarak madeuse of moralism rhetoric and pragmatic coercion that disenfranchised the society ofEgypt from the state structure and interest articulation which were not sustainable forthe longer term. It is argued that the revolution was rolled back as the Morsi regimeapplied the same tactics his predecessor had applied.
Role of UN on J and K under International Law: A Paradigm Shift from Active Mediation to Passive Engagement
Authors: Rahman Adnan , Mahmood Ataullah Khan , Shahbaz Saqib
Published: March 2022

The purpose of this paper is to critically analyze the role of the UN on the conflict of J and K. The Kashmir Issue has been on the agenda of the UN since 1948. There are many stages of the UN's intervention for the resolution of this protracted conflict. There is a need to critically analyze the role of the UN in the conflict of J and K. This research paper will analyze the role of the UN in a critical manner to explore the causes and circumstances responsible for the failure of the UN in resolving this conflict. The findings of this paper will be based upon the literature review on the conflict of J and K and UN's mediation. This study can be very useful in the future to analyze the role of the UN in resolving international disputes and to evaluate the causes of the failure of the UN in different protracted conflicts.
China's Policy in Afghanistan: Internal Factors Shaping Developments
Authors: Akhter Muhammad Nauman
Published: March 2022

Since Xi Jinping assumed the presidency, his ambitions for China to be at aa prominent place in the world have accelerated China's diplomatic engagement with the neighboring countries. Before Afghanistan came on the Chinese radar, it was the low priority area as far as China's economic, political, social, and cultural relations were concerned. Now, China's emerging economic profile requires it to re-calibrate its engagement policy with Afghanistan. The paper opines that some internal policy changes in China have been the main factors in the Chinese policy shift towards Afghanistan. Now, China's vision about Afghanistan internally rests on three pillars: XiJinping's arrival, the New Neighborhood policy and BRI. Consequently, Afghanistan holds a substantial amount of attention in Chinese foreign policy.
Exploring the Role of Non-Governmental Organizations during COVID-19 Pandemic in Pakistan
Authors: Akram Madieha , Hamid Nazia , Hayat Aamir
Published: March 2022

The purpose of this research was to examine the role of NGOs during COVID-19. Covid-19 pandemic was substantially more than a health crisis, it's also a significant financial crisis. Qualitative data was collected in this research through interview guide from administration of NGOs. In this research working of NGOs, challenges confronting to NGOs, nature of coordination of NGOs with different stakeholders, strategies used by the NGO’s, response of people regarding the services, how NGO’s managing their resources for providing services during COVID-19 pandemic was studied. It was found that NGOs were providing assistance to the patients of the Covid-19 as well as facilitating them in all respect related to treatment of Covid-19.It was recommended that NGOs should have to build up their electronic communication capacity, build up their site and discuss consistently with NGOs individuals.
A new method for quantification of frontal retrusion and complex skull shape in metopic craniosynostosis: a pilot study of a new outcome measure for endoscopic strip craniectomy
Authors: Sakar Mustafa , Haidar Hassan , Sönmez Özcan , Erdoğan Onur , Saçak Bülent , Bayri Yaşar , Dağçınar Adnan
Published: March 2022

OBJECTIVE

The objective of this study was to propose a new skull outline–based method to objectively quantify complex 3D skull shapes and frontal and supraorbital retrusion in metopic craniosynostosis using 3D photogrammetry.

METHODS

A standard section from 3D photogrammetry, which represents the trigonocephalic shape, was used in this study. From the midpoint of the area of this section, half diagonals were calculated to the skull outline at 5° increments in the anterior half of the head. These half diagonals were used to create a sinusoidal curve, and the area under the sinusoidal curve (AUC) was used to represent the mathematical expression of the trigonocephalic head shape. The AUC from 0° to 180° (90° from the midline to each side) was calculated and is referred to as AUC0→180. The AUC from 60° to 120° (30° from the midline to each side) was also calculated and is referred to as AUC60→120. A total of 24 patients who underwent endoscopic strip craniectomy and 13 age- and sex-matched controls were included in the study. The AUC values obtained in patients at different time points and controls were analyzed.

RESULTS

The mean preoperative AUC60→120 and AUC0→180 in the patients were significantly lower than those in control individuals. The increase in both AUC60→120 and AUC0→180 values is statistically significant at the discontinuation of helmet therapy and at final follow-up. Receiver operating characteristic curve analysis indicated that AUC60→120 is a more accurate classifier than AUC0→180.

CONCLUSIONS

The proposed method objectively quantifies complex head shape and frontal retrusion in patients with metopic craniosynostosis and provides a quantitative measure for follow-up after surgical treatment. It avoids ionizing radiation exposure.
Iliac Crest Bone Graft Harvesting: Modified Technique for Reduction of Complications
Authors: Pokharel Rohit Kumar , Paudel Sushil , Lakhey Rajesh Bahadur
Published: March 2022

Bone graft harvesting is one of the common procedures in orthopaedics surgery, and iliac crest is the gold standard donor site for autologous bone graft. There are a number of complications related with harvesting iliac crest bone graft, “donor site pain” is the commonest one. We modified the conventional surgical technique for autogenous iliac crest bone graft on patients who underwent anterior cervical decompression/corpectomy and fusion surgeries. Among 23 patients, 18 didn’t complain more pain at the donor site compared to the neck pain on the first postoperative day and the wound on the iliac crest did not affect their mobilisation. Mean Visual Analog Score was 2.62±1.80, 1.83±1.41, and 1.10±1.20 at the time of suture removal (14 days), at six weeks and three months respectively. At one year of follow-up, no patient complained of donor site pain. Our surgical modification has encouraging results and thus can be advocated for bone graft.
Congenital Colour Vision Deficiency among Patients Attending Outpatient Department of Ophthalmology in a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Shrestha Priyanka , Pradhan Pranil Man Singh
Published: March 2022

Introduction: Congenital colour vision deficiency may affect a person’s day-to-day activity and may also affect the choice of occupation a person chooses. This study aims to find the prevalence of congenital colour vision defects in patients presenting in outpatient department of Ophthalmology in a tertiary care centre.
Methods: A descriptive cross-sectional study was conducted in a tertiary care centre after receiving ethical clearance from the Institutional Review Board of Kathmandu Medical College and Teaching Hospital (Reference number: 1006202102). The study was conducted for a 3 months period from 2021 July to 2021 September. Research participants were selected by the convenience sampling technique. A detailed ophthalmological examination was performed and colour vision was tested using Ishihara pseudoisochromatic colour vision chart. Only congenital colour vision defects were included in the study. Statistical Package for the Social Sciences version 20.0 was used for data analysis. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data.
Results: The overall prevalence of congenital colour vision deficiency was 14 (5.24%) (2.54-7.86 at 95% Confidence Interval). The prevalence of congenital colour vision defects in females was 1 (0.74%) and in males was 13 (9.77%). The mean age of the participants with congenital colour vision deficits was 27.42±7.90 years.
Conclusions: The prevalence of congenital colour vision deficiency was similar to the prevalence in other studies done in a similar setting. Awareness should be raised about this condition and people need to be screened at an early age to prevent disappointments in career choices later in life.
European Union interaction with South-Eastern Mediterranean: From “Ring of friends” to “Ring of fire”
Authors: Timakova Olga
Published: March 2022

The Mediterranean region is key in the policy of the European Union, and the countries of the Middle East and North Africa are singled out in the group of Southern neighbors. Over the past decade, the region has undergone a profound transformation. Large-scale challenges - political instability, terrorism, migration, environmental problems and natural disasters - are beyond control. Crisis trends in the Middle East and most of North and Central Africa cause unpredictable and, most importantly, significant side effects that affect not only the security and stability of Europe, but also the functioning of the world system. Destabilizing events have led to the fact that the Mediterranean is now viewed as a source of existential threats. 
Moreover instability in the Southeast Mediterranean has dramatically changed the EU's perspective of the regional partners from a “ring of friends” to “a ring of fire”. This trend is recognized at the official level in the states of Europe, as well as in the EU and NATO. The lack of progress in various EU Euro-Mediterranean Partnership initiatives since the onset of the Arab Spring crises has resulted in a loss of MENA public confidence in EU. 
The article examines the conceptual foundations of the European Union for their policy towards the countries of the Southeast Me-diterranean, as well as identify the key EU approaches in countering the threats and challenges that arise in the region.
The impact of accumulation, human capital and institutions on productivity growth in the advanced economies and developing countries
Authors: Meliantsev Vitalii A.
Published: March 2022

According to the authors' calculations, such an important determinant of economic progress as the share of total investments (TIs) in physical and human capital (PK and HK) in GDP, having amounted for the whole world at the stage of the 1st and 2nd industrial revolutions (IR) in 1800-1950 to 12 to14%, increased by 2016-2020 (stage of transition from the 3rd to the 4th IR) 3.5 times, exceeding 2/5 of the world GDP. By this key parameter, developing countries (DCs) as a whole have already surpassed the advanced economies (AEs; in 2016-2020 45% vs 43% of GDP). However, the share of investments in HK in TIs in the DCs is on the whole only half of that in the AEs (1/4 vs 1/2).
Calculations and models, made for the AEs, the main regions and a number of large DCs, revealed that (1) in the long term, an increase in the share of their TIs significantly and markedly affected dynamics of their per capita GDP (PCGDP), labor productivity (LP) and total factor productivity (TFP). Higher growth rates of LP in large DCs compared to large AEs in 2000-2020 were due respectively by 2/5 and 1/4 to much more substantial increase in the former of their TIs in GDP, as well as to the increase of their government effectiveness and the quality of institutions. (3) Almost fourfold superiority of the AEs over DCs in terms of PCGDP is brought about by 1/3; 2/5 and 1/5, respectively, by higher values in the former of their indicators of technological development, educational attainment of the population and the rule of law.
My “Anti-Bakhtin”: (on the Issue of Interpretation of Dostoyevsky’s Story “The Dream of a Ridiculous Man”)
Authors: Kibalnik Sergej A.
Published: March 2022

The article demonstrates in detail the numerous inaccuracies allowed by Mikhail M. Bakhtin in his interpretation of Dostoevsky’s “fantastic story”. The stress on the role of the “menippea” and consequently on the ambivalence of “The Dream of a Ridiculous Man” makes him overlook the main import of the story. The meaning of the story might be grasped only by taking into account Dostoevsky’s artistic use of a set of Christian ideas. Striving – though rather inaccurately – to account for auto-intertextuality of “The Dream” in relation to many other previous and subsequent works of Dostoevsky, Bakhtin fails to recognize the specifically Dostoevskian formulation of the theme. And, accordingly, he skips the motives of the ruinous universal “indifference” (Russ. “ravnodushiye”), the impossibility of preserving the “integrity” (Russ. “tselostnost’”) of consciousness in the modern world and all the consequent imperfections of man. Meanwhile, a detailed tracing of the inner affinity of Zosima, Alyosha and even Ivan with the “ridiculous man” makes it possible to point out some recurring motives and, accordingly, the key stages of formation of the late Dostoevsky’s concept of the renewal of the world and the techniques of its artistic embodiment. The work also shows how the shortcomings of the Bakhtinian approach to Dostoevsky occasionally surface in modern Dostoevsky studies impacting the interpretation of “The Dream of a Ridiculous Man”.
About the Word-Order in Old Russian Noun Phrases with Pronominal Adjectives (on the Material of Direct Speech in “The Tale of Bygone Yearsˮ)
Authors: Savelyev Victor S.
Published: March 2022

The article is devoted to the study of the word-order in simple noun phrases, which include pronominal adjectives as definitions, in statements of the characters of “The Tale of Bygone Years&8j1; (non-translated dialogic fragments are analyzed). A regularity is established: pronouns in anaphoric and deictic functions are characterized by their common use in postposition relative to the main component, and pronouns in cataphoric and quantifier functions are prepositive usually. It is also established that the main reason for a variation of the usual word-order is the need for communicative highlighting of the component of the phrase moved to the preposition. At the same time, the usual use of quantifiers in preposition is not associated with their communicative selection, but with the fact that, being indicators of referential status, in combination with the components being determined, they form a kind of “complex words&8j1;, the “decoding&8j1; of the meanings of which in a linear flow of speech implies the first stage of this "decoding" is the establishment of a referential status. The described patterns of the word-order are associated, in our opinion, with the fact that direct speech depicts oral speech, reflecting its linearity: the first in the focus of the listener's attention is the prepositive component, which determines its emphasis – semantic and / or communicative.
THE 16TH INTERNATIONAL CONFERENCE “PERSON/FACE IN LANGUAGE AND COMMUNICATIONˮ
Authors: Fufaeva Irina
Published: March 2022

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Postabortion case load study in Egyptian public sector hospitals
Authors:   Egyptian Fertility Care Society,   Population Council
Published: March 2022

There is an absence of reliable data on the incidence of incomplete abortion in Egypt. A diagnostic, descriptive study that neither tests an experimental intervention nor evaluates in a comprehensive manner the quality of postabortion medical care was undertaken to address this issue. The study is a cross-sectional observation of the volume and nature of the postabortion case load in Egyptian public-sector hospitals, and it responds to the following objectives: 1) Accurately estimate the number of women who present for postabortion treatment in ob/gyn in-patient facilities as a percentage of ob/gyn admissions in a representative sample of Egyptian public-sector hospitals during one month; 2) Describe the medical and sociodemographic characteristics of the postabortion patients, including the cause(s) of the lost pregnancies, whether the pregnancy was wanted, the medical treatments received, and contraceptive-use history. As stated in this report, the study's sampling frame consists of the approximate 569 public-sector hospitals in Egypt. Approximately 15 percent of the hospitals were randomly selected with the probability of selection proportionate to the average number of beds in each hospital, using standard sampling procedures.
Considerations regarding the EC Regulation no.261/2004 from the Perspective of the Protection of Passengers, but also of Air Transport Operators
Authors: Bularca Anca Roxana
Published: March 2022

The study regarding the interpretation and application of the provisions of the EC Regulation no. 261/2004 aims to highlight theoretical and practical aspects outlined since the entry into force of this normative act and until now. The European legislator has adopted this normative act, with direct binding force for the member states of the European Union, in order to ensure a protection of passengers who have concluded air transport contracts with different effective air transport operators. In essence, passengers are consumers and air carriers are in a dominant position, as a contracting party, in this type of contract, which is usually one of accession. However, the interpretation and application of this normative act in the different Member States has generated non-unitary practices from the perspective of the terms defined by the Regulation, but also unfair practices in the sense of forming an immoral market in which the right to compensation is traded.
Current Practical Approaches to Tort Liability in the Case of Service Rapports of Civil Servants
Authors: Manea Laura
Published: March 2022

The analysis of the present study started from the text of art.1 and art.18 of Law no.554 / 2004, according to which an action can be filed in the administrative contentious court only regarding the granting of compensations for the damages created by issuing illegal administrative acts. The special provisions of the law on administrative litigation were opposed, in the comparative analysis, the provisions of the Civil Code on tort liability so that by corroborating with the solutions of the courts to be outlined a legal regime regarding the liability of civil servants.
Jurisdiction over Cross-Border Insolvency Proceedings
Authors: Savu Codrut Nicolae
Published: March 2022

The analysis of the opening of insolvency proceedings under European Union law involves the identification of incidental rules applicable to the insolvency proceedings with an element of foreignness when it concerns the Member States. In order to ensure a comprehensive understanding of cross-border insolvency proceedings, it is necessary to analyze the relevant rules in the field of private international law, when the international character of the insolvency legal relationship is reflected in relation to another third country of the European Union.
Considerations regarding the Refusal of Execution of the European Arrest Warranty
Authors: Aron Ioan
Published: March 2022

The third millennium comes up with a new framework in the field of social life, as well as in the field of cross-border crime, which faced significant increases, generated by the enlargement of the European Union, which eliminated internal border controls thus facilitating the movement of criminals and goods, which are the subject of organized crime and terrorism. The institution of extradition, in this context, experienced some operational imperfections, so that it was necessary to adopt new judicial procedures for the arrest and surrender of offenders in the Member States to the requesting State by establishing the European arrest warrant.
„Oral History takes place“. Über ortbezogenes Spurenlesen DDR-bezogener Grenzerinnerungen
Authors: Leipold Ralf
Published: March 2022

Als einer Teildisziplin der Geschichtswissenschaft kommt der Oral History gemeinhin die Aufgabe zu, mit der „Zeit zu rechnen“, insofern Erzählungen über das Leben nicht selten nur zeitlich rückgebunden werden. Der folgende Beitrag versucht diese Ansicht einmal gänzlich umzudrehen, indem davon ausgegangen wird, dass Oral History und deren Untersuchungsgegenstände nicht nur zeitlichen Direktiven gehorchen und derart untersuchbar scheinen, als mündlich dargebotene Geschichte immer auch und vor allem in räumlicher Hinsicht „stattfindet“. Hiernach avanciert nicht nur die gelebte Biographie zur raumgewordenen Lebensgeschichte, mithin zur gelebten Geographie, zum persönlichen Schauplatz der Geschichte, als vielmehr auch der im Mittelpunkt des Forschungsinteresses stehende lebensgeschichtliche Erzähler sich über den Zeitzeugen hinaus ferner als Ortszeuge offenbart. Dass erzählte Lebensgeschichten neben ihrer Zeitgebundenheit immer auch eine Ortsgebundenheit aufweisen, wird nachfolgend zur Grundmaxime erklärt und am Topos der Spur und des Spurenlesens theoretisch wie methodisch genauer nachvollzogen. Schlussendlich wird an der Lebensgeschichte Karl Westhäusers fallbeispielhaft zu zeigen sein, welche empirischen Potenziale und Erträge eine Suche nach ortsbezogenen Erinnerungsspuren mit sich führen kann, um – im eigenen Fall – verborgenen DDR-Grenzerinnerungen auf die Spur zu kommen.
Neuanfang unter Maos langem Schatten? Oral History im heutigen China
Authors: Freund Alexander
Published: March 2022

Die Geschichte der Oral History in China ist lang, vielschichtig und zuweilen turbulent. Dieser Überblicksartikel – eher eine journalistische Reportage als ein wissenschaftlicher Artikel – berichtet über einige Aspekte der Geschichte und Gegenwart der Oral History in China im zwanzigsten und frühen einundzwanzigsten Jahrhundert. Eine Grundannahme ist, dass ein historiographischer Zugang auch für Oral Historians in anderen Ländern von Interesse sein kann. Es wäre wünschenswert, wenn mit diesem Artikel eine Debatte unter Oral Historians über die nationale und internationale Bedeutung von Chinas langer Geschichte der Oral History angeregt werden kann, um so auch die aktuelle globale Praxis zu bereichern.
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase IIb Clinical Study to Evaluate the Safety and Efficacy of DHP1401 in Patients with Mild to Moderate Alzheimer’s Disease Treated with Donepezil: DHP1401 Randomized Trial in Mild to Moderate Alzheimer’s Disease (DRAMA)
Authors: Shim YongSoo , Han Hyun Jeong , Park Kyung Won , Kim Byeong C. , Park Kee Hyung , Park Mee Young , Kim Hee-Jin , Moon So Young , Choi Seong Hye , Park Kun Woo , Yang Dong Won , Yoon Soo Jin , Kim Sang Yun , Youn Young Chul , Choi Hojin , Yoon Koung Eun , Cho Hyun Ju , Han Seol-Heui
Published: March 2022

Background: Preclinical studies in transgenic models of Alzheimer’s disease (AD) suggest that DHP1401 has neuroprotective and memory-enhancing effects. Objective: To evaluate the efficacy and safety of DHP1401 in AD patients treated with donepezil Methods: Methods: In a double-blind study, patients with mild-to-moderate AD were randomized (1:1:1) to receive a twice daily total dose of 500 mg or 1000 mg DHP1401 or placebo for 24 weeks. Tolerability and safety were monitored at baseline and weeks 12 and 24. Results: total of 180 patients were randomized to Active 1 (500 mg: n = 62), Active 2 (1000 mg: n = 53), and control groups (n = 65) in 16 sites in Korea. There was no significant difference in the Alzheimer’s Disease Assessment Scale (ADAS-cog) score, the primary efficacy endpoint, from baseline. However, in the subgroup with mild AD patients (MMSE, 20–26) who received the high dose of DHP1401 and the group that received donepezil 5 mg, the ADAS-cog scores improved. MMSE and K-TMT-e type B were significant in both active groups at week 24. The most frequently observed symptom was dizziness (2.78%), and the most commonly observed reactions were related to metabolism and nutrition disorders (5.00%). No remarkable adverse events were observed for 24 weeks. Conclusion: Although the effectiveness of DHP1401 was not proved to be superior as the primary efficacy endpoint, the secondary endpoints, MMSE and K-TMT-e type B, showed significant beneficial effects. Also, the subgroups showed that ADAS-cog scores significantly were improved. DHP1401 could be proven beneficial for the AD treatment by further clinical trials.
Avoiding Over-Reliance on Multi-Domain Interventions for Dementia Prevention
Authors: Daly Timothy , Mastroleo Ignacio , Migliaccio Raffaella
Published: March 2022

Given the unknown therapeutic value of targeting Alzheimer’s disease pathology and the discovery of robust risk factors for dementia, non-pharmacological risk reduction (RR) is increasingly offered as an alternative to targeting Alzheimer’s disease pathology. While RR will surely be a useful tool to make public health gains, we propose solutions to three possible issues with over-reliance on multi-domain interventions to achieve RR: limited individual impact, an exclusive focus on later life, and overlooking social determinants of dementia. We argue in favor of a broader debate within the research community and greater society about how different therapeutic avenues should be explored.
Investigating Causal Relations Between Circulating Metabolites and Alzheimer’s Disease: A Mendelian Randomization Study
Authors: Huang Shu-Yi , Yang Yu-Xiang , Zhang Ya-Ru , Kuo Kevin , Li Hong-Qi , Shen Xue-Ning , Chen Shi-Dong , Chen Ke-Liang , Dong Qiang , Tan Lan , Yu Jin-Tai
Published: March 2022

Background: Metabolomics is a promising approach that can be used to understand pathophysiological pathways of Alzheimer’s disease (AD). However, the causal relationships between metabolism and AD are poorly understood. Objective: We aimed to investigate the causal association between circulating metabolites and risk of AD through two-sample Mendelian randomization (MR) approach. Methods: Genetic associations with 123 circulating metabolic traits were utilized as exposures. Summary statistics data from International Genomics of Alzheimer’s Project was used in primary analysis, including 21,982 AD cases and 41,944 controls. Validation was performed using family history of AD data from UK Biobank (27,696 cases of maternal AD, 14,338 cases of paternal AD, and 272,244 controls). We utilized inverse-variance weighted method as primary method. Results: We found significantly increased risks of developing AD per standard deviation increase in the levels of circulating ApoB (odd ratio[OR] = 3.18; 95% confidence interval[CI]: 1.52–6.66, p = 0.0022), glycoprotein acetyls (OR = 1.21; 95% CI: 1.05–1.39, p = 0.0093), total cholesterol (OR = 2.73; 95% CI: 1.41–5.30, p = 0.0030), and low-density lipoprotein (LDL) cholesterol (OR = 2.34; 95% CI: 1.53–3.57, p = 0.0001). Whereas glutamine (OR = 0.81; 95% CI: 0.71–0.92, p = 0.0011) were significantly associated with lower risk of AD. We also detected causal effects of several different composition of LDL fractions on increased AD risk, which has been verified in validation. However, we found no association between circulating high-density lipoprotein cholesterol and AD. Conclusion: Our findings suggest causal effects of circulating glycoprotein acetyls, ApoB, LDL cholesterol, and serum total cholesterol on higher risk of AD, whereas glutamine showed the protective effect.
Fusion of diversified utility factors for high utility mining
Authors: Bokir Abdullah , Narasimha V.B
Published: March 2022

High utility mining is gaining prominence, and with the increasing set of business intelligence models, the scope of such significant practices is high. Rather than focusing only on profitability as one key utility metric, today’s organizations believe in having more robust levels of the multi-objective filtering process. In this manuscript, a contemporary model of the high utility mining process is proposed, wherein the multiple averages are used for grading the recommendation of the itemsets for merchandise. The model’s key advantage is its dynamic approach. The goods-related period of the average time interval can be flexible, alongside the fusion of multiple utility thresholds of diversified features chosen for itemsets recommendation. The performance analysis has been carried out by using a multi-fold cross-validation strategy. The results obtained for cross-validation show that the proposed model is outperforming the contemporary models with significant precision, specificity, sensitivity, and accuracy having values 97%, 95%, 98%, and 97% in respective order. Whereas, the contemporary models HUPM-MUO and MOEA-FHUI have obtained 93% and 90%, 88% and 82%, 89%, and 84%, and 89% and 83% in respective order of the corresponding metrics. The experimental study of the model denotes the effectiveness and ease with which the solution can generate results and produce significant output in the real-time environment for more dynamic and periodic decisions by different organizations.
Incrementally updating high utility quantitative itemsets mining algorithm
Authors: Han Meng , Shan Zhihui , Han Qiang
Published: March 2022

High utility quantitative itemsets (HUQI) mining is a new research topic in the field of data mining. It not only provides high utility itemset (HUI), but also provides quantitative information of individual item in the itemset. HUQI can provide decision makers with information about items and their purchase quantities. However, the currently proposed HUQI mining algorithms assume that the datasets are static. In order to solve this problem, an incremental quantitative utility list (IQUL) data structure is proposed to store item information, including item name, item number, transaction weight utility of item, each entry in the list stores the transaction identifier, the utility of the original data, the remaining utility, the utility of the incremental data, the remaining utility, and the sum of the utility and the remaining utility. When data is inserted, the item information will be updated. Based on IQUL, an incrementally updating HUQI (IHUQI) mining algorithm is proposed to mine HUQI on incremental update data. A large number of experiments on real datasets show that the IHUQI algorithm can effectively mine HUQI Experimental results show better performance on sparse datasets.
Efficacy improvement of aspect-based sentiment analysis using enhanced rule –based approach and domain-specific lexicon (ERBA-DSL)
Authors: M Devi Sri Nandhini , Gurunathan Pradeep
Published: March 2022

Since people express their opinions and feelings more openly than ever before, sentiment analysis proves to be a promising research area that effectively analyses the opinion expressed over the entities. In this context, Sentiment analysis is utilized to gather valuable insights from users’ opinions. These insights would benefit a lot for the business concerns and institutions to improve their respective products/services. Aspect-based sentiment analysis (ABSA) is the most robust technique that offers a more fine-grained analysis. The objective of this paper is to improve the efficacy of ABSA by framing a robust and enhanced set of rules. Several experiments were carried out to detect explicit and implicit aspects. The hybrid approach comprising of enhanced rule-based approach (ERBA) and domain-specific lexicon (DSL) is used to improve the solution of the aspect-based sentiment analysis problem. The proposed approach employs a domain-specific adjective-noun collocation list(DSANCL) tailored to the domain for fine-tuning the process of implicit aspect detection(IAD). The proposed model frames a new nine-point scale for measuring the sentiment strength by introducing a ternary classification of intensifiers based on their degree of intensification. The performance of the proposed model is evaluated using the university reviews dataset.
Nature inspired fault tolerant task allocation in cloud computing using neural network model
Authors: Gupta Punit , Rawat Pradeep , Tripathi Rajan Prasad , Mundra Ankit , Mundra Shikha , Goyal Mayank Kumar , Kaur Mandeep , Agarwal Ruchi
Published: March 2022

Cloud computing in the current scenario comes with a large pool of resources, pay-per-use model and reliable infrastructure. Cloud optimization relies on resource optimization to improve the performance and reliability of the cloud. Fault in the cloud places an important role in defining the reliability of the cloud. The identification of fault is a challenging issue in a modular cloud environment. The researchers have developed various methods for the fault-aware scheduling of cloud resources. The fault-aware resource allocation includes static, dynamic, meta-heuristic, and learning-based approaches. In this article, we primarily focused on existing fault-aware resource allocation techniques and then we proposed a model that will primarily focus on fault forecast in tasks allocation. The projected model is based nature-inspired heuristic approach and intelligent artificial neural network. The fault-tolerant aware ANN-based proposed model focuses on performance improvement and reliability testing proactively. The proposed model surpasses the existing state of art methods for proactive and reactive fault-aware scheduling techniques in a large scale datacenter. The results and discussions section support the reliability assertion of the fault-tolerant aware human brain and nature-inspired model.
Development of an integrated blended learning model and its performance prediction on students’ learning using Bayesian network
Authors: Lakho Shamshad , Jalbani Akhtar Hussain , Memon Imran Ali , Soomro Saima Siraj , Chandio Asghar Ali
Published: March 2022

With the spread of the COVID-19 pandemic, the importance of online learning has grown up worldwide and many higher education institutions used this mode of learning to save the timings of students. Just Online learning does not fulfill all the learning requirements of undergraduate students, therefore, there is a need for the blended learning (BL) method to be adopted in higher educational institutes for the enhancement of students’ learning outcomes. This research paper focuses on the development of an integrated blended learning model and the performance of the model on students’ learning has been predicted using a Bayesian network (BN) classifier. The proposed model is based on the medium impact blend of the Rotation model and the Enriched Virtual Model and applied to undergraduate computing students. The Data Structures and Algorithms course is targeted for the prediction of students’ performance. The findings of the proposed Integrated BL model show that when students properly attend the classroom lectures followed by their associated lab practical in the Rotation Model and follow the online learning activities in the Enriched Virtual Model properly, then their learning outcomes may be increased as predicted using BN method. The proposed model also reports an overall accuracy of 88.5% on the collected data.
Synthesis, characterization and fuzzy simulation of ZnO thin film on flexible substrate
Authors: Imran Muhammad , Butt Alvina Rafiq , Qasim Faheem , Fahad Hafiz Muhammad , Sher Falk , Waseem Muhammad Faisal
Published: March 2022

ZnO is promising material for the electronic and optoelectronic devices. In present work we have fabricated the ZnO film by DC reactive magnetron sputtering. The variations of reactive and sputtering gases affect the crystallite size and band gap of ZnO film. In present work the ZnO film is prepared at 50 watt power by DC reactive spurting method. The fuzzy simulation has been performed to estimate the best argon oxygen gas ratio which gives the better crystallinity and band-gap. The structural analysis shows that the ZnO film has hexagonal wurtzite structure. The UV-vis spectroscopy has been employed to find the band gap.the measured band gap value of ZnO is 3.21 eV. The fuzzy rule based system and characterization results are in accordance with each other with a minimal difference of less than 1%.
Multi-group multi-verse optimizer for energy efficient for routing algorithm in wireless sensor network
Authors: Jia Han-Dong , Li Wei , Pan Jeng-Shyang , Chai Qing-Wei , Chu Shu-Chuan
Published: March 2022

Wireless sensor network (WSN) is a network composed of a group of wireless sensors with limited energy. With the proliferation of sensor nodes, organization and management of sensor nodes become a challenging task. In this paper, a new topology is proposed to solve the routing problem in wireless sensor networks. Firstly, the sensor nodes are layered to avoid the ring path between cluster heads. Then the nodes of each layer are clustered to facilitate the integration of information and reduce energy dissipation. Moreover, we propose efficient multiverse optimization to mitigate the impact of local optimal solution prematurely and the population diversity declines prematurely. Extensive empirical studies on the CEC 2013 benchmark demonstrate the effectiveness of our new approach. The improved algorithm is further combined with the new topology to handle the routing problem in wireless sensor networks. The energy dissipation generated in routing is significantly lower than that of Multi-Verse Optimizer, Particle Swarm Optimization, and Parallel Particle Swarm Optimization in a wireless sensor network consisting of 5000 nodes.
Viruses without borders and the medical research agenda
Authors: Stegenga Jacob
Published: March 2022

The COVID-19 pandemic has shown us that there are numerous research questions—empirical, political, and philosophical—that need addressing both prior to, during, and after a pandemic. The current organisation of medical research has hindered our ability to efficiently answer these questions. This in turn suggests that there ought to be changes to how the medical research agenda is set.
The social organization of science during the COVID-19 pandemic
Authors: Fernández Pinto Manuela
Published: March 2022

BACKGROUND: The COVID-19 pandemic has shocked society worldwide. Multiple efforts went immediately into developing treatments for managing and vaccines for preventing the disease. National and international initiatives emerged to deal with the deep economic and social inequalities in our world today. OBJECTIVE: To show that the global inequalities that have become salient during the COVID-19 pandemic and specially with the global vaccination campaign, are the result of a highly privatized system of research and development (R&D), which is first and foremost profit-driven, and where epistemic and social concerns are not prioritized. METHODS: Philosophical analysis. RESULTS: After exploring the current organization of scientific research, as well as its impact in the development of research at a global scale, the paper shows the way in which this highly privatized organization of research has permeated scientific research on COVID-19, identifying who is currently benefiting from pandemic science, and who on the contrary is suffering the consequences of this organization. Using the COVAX mechanism as an example, the paper argues that international efforts to counteract the power of commercially-driven science has not rendered the expected results. CONCLUSIONS: The current organization of science ought to be shaken and restructured if we aim to be better prepared to address the global challenges of the future with the relevant scientific and technological development.
DEVELOPMENT OF SCIENTIFIC-METHODOLOGICAL AND ANALYTICAL APPROACHES TO THE IMPACT OF ECO-INNOVATION ON THE LEVEL OF ORGANIZATIONAL AND TECHNOLOGICAL RELIABILITY OF CONSTRUCTION
Authors: Chernyshev Denys , Prykhodko Oleh , Akselrod Roman , Rуzhаkov Dmуtrо , Homenko Oleksandr , Petrukha Serhii
Published: March 2022

Аt the present stage of development of the construction industry, the synergistic basis of the constituent processes of organizing and managing construction is multiplying. In fact, not a single significant investment construction project is implemented today without a collaboration component at the management level, resource and information interaction, design and construction processes, their documentation, regulatory and legal technical support. In this sense, it is necessary to build a system for the formation of innovative competencies in the field of systems engineering, organization and management of construction. In general, construction management will be improved in the direction of organizational schemes for the formalization of business processes and the formation of correct contractual relations, which will become a decisive factor in innovative development at the level of investors and contractors. Multidimensional project management systems, integrated with modeling and object lifecycle management systems, of a new level will ensure the required quality of object and process analysis and management decisions, including deployed cost management systems, construction timeframes, investment and project risks. Implementation of project management taking into account modern environmental standards should promote the realization of the potential of innovative development of the construction industry. Eco-innovations formally link the duration, resource intensity, organizational, technological and functional characteristics of the construction project with a multifactor analytical basis for ensuring the biosphere compatibility of construction as a leading – in accordance with European requirements - component of organizational and technological reliability of construction.