bluuebunny/crossref_metadata_2025 huggingface dataset:
Janus Kinase-Signal Transducer and Activator of Transcription Inhibitors for the Treatment and Management of Cancer
Authors: Rizwi Fahim Anwar , Abubakar Md. , Puppala Eswara Rao , Goyal Ahsas , Bhadrawamy Ch. Veera , Naidu V. G. M. , Roshan S. , Tazneem B. , Almalki Waleed Hassan , Subramaniyan Vetriselvan , Rawat Sushama , Gupta Gaurav
Published: March 2023

According to the World Health Organization (WHO), cancer is the second-highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the advances in diagnosis and treatment during the last couple of decades, it remains a serious concern due to the limitations of currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. In addition, many etiological factors such as environmental and genetic factors initiate the activation of the Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) pathway. This aberrant activation of the JAK-STAT pathway has been reported in various disease states, including inflammatory conditions, hematologic malignancies, and cancer. For instance, many patients with myeloproliferative neoplasms carry the acquired gain-of-function JAK2 V617F somatic mutation. This knowledge has dramatically improved our understanding of pathogenesis and has facilitated the development of therapeutics capable of suppressing the constitutive activation of the JAK-STAT pathway. Our aim is not to be expansive but to highlight emerging ideas towards preventive therapy in a modern view of JAK-STAT inhibitors. A series of agents with different specificities against different members of the JAK family of proteins is currently undergoing evaluation in clinical trials. Here we give a summary of how JAK-STAT inhibitors function and a detailed review of current clinical drugs for managing cancer as a new therapeutic approach.
Effect of wetting–drying cycles on the desiccation of tailings pre-dewatered with super absorbent polymer
Authors: Roshani Anis , Fall Mamadou , Kennedy Kevin
Published: March 2023

The main objective of this investigation is to understand the desiccation behaviour of fluid fine tailings (FFT) pre-dewatered with a superabsorbent polymer (SAP) with respect to wetting–drying cycles. Raw FFT (control) and pre-dewatered FFT with SAP were subjected to five cycles of wetting and six cycles of drying. Evaporation was found to be the dominant mechanism in the dewatering of raw FFT, as well as FFT pre-dewatered with SAP. In both cases, the suction developed in each drying cycle was eliminated temporarily by the succeeding wetting cycle. The minimum solids content within the column was found to be around 70%, which corresponded to a vane shear strength of 4.5 kPa. Based on the digital images of the surface, the crack intensity factors of the raw FFT and pre-dewatered FFT were calculated to be 26 and 14%, respectively. Scanning electron microscopy and mercury intrusion porosimetry analyses indicated that the FFT pre-dewatered with SAP after 25 days of evaporation in the second lift exhibited the most compacted texture. The solids content of the FFT pre-dewatered with SAP increased to 98% from an initial 50%. The SAP pre-dewatering method can significantly increase the shear strength of FFT subjected to wetting–drying cycles.
Gestão das Tecnologias da Informação: Realidade e Desafios na Estratégia de Fortalecimento de Empreendimentos da Economia Solidária
Authors:   Universidade Federal de São João del Rei, Alves Jean Carlos Machado , Melo Alisson Marques de ,   Universidade Federal de Ouro Preto, Andrade Emmanuel Paiva de ,   Universidade Federal Fluminense, Oliveira Fabrício Batista de ,   Universidade Federal Fluminense, Zotes Luís Perez ,   Universidade Federal Fluminense
Published: March 2023

As tecnologias da informação (TI) se tornaram importantes recursos para os diferentes processos de trabalho das organizações. No contexto de organizações da Economia Solidária (ES) a utilização dessas tecnologias pode se tratar de questões de sobrevivência e estratégia para a organização. Desta forma teve-se como objetivo investigar os desafios na gestão das tecnologias da informação no processo de fortalecimento de movimentos sociais solidários tendo como base as experiências de empreendimentos de Economia Solidária nas cidades de João Monlevade e Nova Era em Minas Gerais - Brasil. Quanto a metodologia realizou-se uma abordagem qualitativa, observação participante, visitas in loco, pesquisa bibliográfica e documental. Buscou-se dados sobre o uso das TI, processos produtivos e a gestão nos empreendimentos. Os resultados demonstraram fragilidades, limitações, potencialidades, necessidades e desafios no que se refere a ES e TI. Mas, também oportunidades aos profissionais de TI atuarem como mediadores no processo de inclusão e desenvolvimento humano.
Diversidad generacional y patrón de uso de Tecnologías de Información y Comunicación
Authors:   Centro de Investigación en Educación, Garay Ignacio Salamanca , Lillo Emilio Sagredo ,   acultad de Educación, Universidad Católica de la Santísima Concepción
Published: March 2023

El objetivo es describir el patrón de uso de las TIC en cinco generaciones. La metodología es cuantitativa no experimental. Se miden 4 dimensiones: uso del computador, uso de internet, uso de redes sociales y uso de aplicaciones móviles. La muestra fue de N=3600 sujetos. Los resultados evidencian que en el uso del computador las generaciones jóvenes prefieren el aprendizaje autónomo, en cambio, las generaciones mayores necesitan ayuda de familiares y/o amigos. En el uso de internet las generaciones afirman que ha mejorado su calidad de vida. Para el uso de redes sociales, las generaciones afirman que las más utilizadas son WhatsApp y Facebook y en el uso de aplicaciones móviles, las generaciones afirman que utilizan Netflix y Spotify. En conclusión, las generaciones presentan usos similares de las TIC, se evidencia que subyace una estructura de uso común que disminuye la idea de brecha digital entre estas.
CODEX ® Multiplexed Imaging – tissue staining in TMA and whole tissue FFPE sections v1
Authors: Martinez Casals Anna
Published: March 2023

CODEX technology allows for highly multiplexed analysis of + 40 proteins on the same section relying on DNA-conjugated antibodies being commercialized by Akoya Biosciences (former name CODEX®, current name PhenoCycler™). This detailed protocol describes an adapted protocol, from CODEX User Manual Rev C , for tissue staining in Tissue MicroArrays (TMA) and whole tissue Formalin Fixed Paraffin Embedded (FFPE) sections to run into the CODEX system which is used in Emma Lundberg research group at Science for Life Laboratory; KTH - Royal Institute of Technology.
ONT dA-tailing for Fungal Barcoding v2
Authors: Douglas Russell Stephen
Published: March 2023

This protocol is for dA-tailing, which is an enzymatic method for adding a non-templated nucleotide to the 3' end of a blunt, double-stranded DNA molecule. In other words, this puts A-chains on the end of our PCR product, creating a site for the ligation adapter to attach to. Simple process - create a reaction with three chemicals, cleanup the product with beads. Time required: ~45 minutes The NEB protocol this is based on can be found here.
Preparing ONT-tagged Primers and Master Mix for Fungal DNA Barcoding v2
Authors: Douglas Russell Stephen
Published: March 2023

ONT primer preparation has two specific aspects that are unique when comparing to Sanger sequencing protocols. The first is that each primer needs to be "tagged" - a unique ~10-15bp sequence is added to the 5' end of the forward and reverse primers. Secondarily, these tagged primers need to be "multiplexed" - meaning that each individual specimen has a unique combination of forward-tagged primer and reverse-tagged primer. These tags allow the DNA amplicons for all of the specimens to be "pooled" or mixed together for sequencing, and then to be "demultiplexed" or sorted back out, allowing the resulting sequences to be associated with the individual specimens they originated from. It is possible to perform ONT sequencing without the tags, but you would not be able to associate the sequences with any individual specimens. Ex - If you had ten closely related Russula specimens in your sequencing run, you would be able to document sequences of all ten of the species, but you would have a difficult time associating the sequences with the individual specimens/observations they originated from. They would be sequences without faces. This may be common if you are examining the community ecology or environmental DNA of a particular location, but this result would not be ideal for most DNA barcoding goals involving specimens. Thus, if you are running 960 specimens on a Flongle flowcell, you need to have 960 unique primer combinations for the sequencing run. The easiest way to accomplish this is to have a single unique forward primer tag for each plate you are including, combined with 96 unique reverse primers for the plate. If you are including five plates, you would have five unique forward primers (a different one for each plate) combined with a standard set of 96 reverse primers. This results in 960 unique tags for each of the 960 specimens that are being barcoded. Note: This protocol utilized a primer plate of 96 different reverse primers. In the future I plan on ordering the primer plate of 96 unique primers for the forward ITS1F primers. This will allow ad-hoc combinations of a different ONT-tagged reverse primer to extend into the LSU region as needed.
Effect of dietary nano α-tocopherol acetate plus selenium on productivity, immune status, intestinal morphometry and carcass traits of broiler chicken
Authors: Abdulameer Yahya , Ajafar Majeed , Rabee Raed
Published: March 2023

Background: Nano-vitamins and minerals are used in animal nutrition to improve performance and health of broiler chickens as a potential alternative to antibiotic growth promoters. Objective: To evaluate the effect of several levels of a dietary nano α-tocopherol acetate plus selenium compound (NTS) on growth, intestinal histomorphometry, carcass traits, and immune status of broiler chickens. Methods: A total of 240 one-day-old Ross 308 chickens were randomly divided into four groups, each one with three pens (n=20 per pen). Four doses of nano α-tocopherol acetate and selenium (0, 5, 7, and 10 mg/kg) were included in the basal diet for 42 days. Results: Final body weight, cumulative body weight gain, and final conversion ratio significantly improved with increasing NTS levels (p<0.05). Carcass traits and weight of internal organs increased in the groups fed 7 and 10 mg/kg NTS. High NTS doses significantly increased immune vaccine titers against Newcastle disease, avian influenza virus, infectious bursal disease, and infectious bronchitis. Moreover, dietary addition of NTS improved intestinal morphometry. Conclusion: Thus, NTS (7 and 10 mg/kg) can be added to poultry rations to improve production, carcass characteristics, and immune status of broilers. Further studies are needed to evaluate NTS residues in meat.
Expanding Cycles of Collaboration and Critical Inquiry in Utopian Methodology. The 360 Education Alliance Case
Authors: Esteban-Guitart Moises , Rajala Antti , Cole Michael
Published: March 2023

The article proposes and illustrates a methodological framework that aligns with the action-research models and utopian methodology in particular, although it represents a more substantial leap forward, especially regarding the distributed nature of decision making in the different processes of research/intervention, and its multiple and systematic nature (linking theory, practice and politics). It is developed through four main phases: i) collective identification of the needs and the object of the study, ii) expansive co-design of the action-research, iii) dynamic and multiagency implementation, and iv) critical and participatory reflexive evaluation. It is examined more specifically how the phases proposed here can be illustrated by an ongoing project called 360Education Alliance (“Aliança Educació 360”) conducted in the context of Catalonia, Spain. It consists of a partnership presented in January, 2018, that currently involves more than 300 entities for promoting a community vision of education based on improving equity and social justice. Some opportunities deriving from this methodology are mentioned in the conclusion, emphasizing the transversal role of self-criticism as permanent inquiry of multiple agents involved in the process, including the participants themselves.
Improvement of power quality in power supply systems of rolling mills using frequency converters with active rectifiers due to use of specialized passive filters
Authors:   Nosov Magnitogorsk State Technical University, Nikolaev A.A. , Afanasyev M.Yu. ,   Nosov Magnitogorsk State Technical University, Gilemov I.G. ,   Nosov Magnitogorsk State Technical University, Bulanov M.V. ,   Nosov Magnitogorsk State Technical University
Published: March 2023

In recent years, the frequency converters (FC) with active rectifiers (AR) have become widespread due to their advantages. The advantages are the possibility of energy recovery in braking modes of electric drive and support of the set value of power factor at the input of AR. At the same time these converters have a significant disadvantage, that is the deterioration of voltage quality in the in-plant 6–35 kV power distribution network due to the imposition of high-frequency harmonics of the input voltage and current of AR on the resonant area of the supply network frequency response. This disadvantage can be eliminated by using special passive filters in the in-plant power networks. They ensure the shift of the main resonance of currents to a zone free from high-frequency harmonics of the FC with AR. It makes possible to reduce the harmonic distortion coefficient in the voltage sections of the main stepdown substation (MSS) of the enterprise. Processing of experimental data is carried out in the Matlab mathematical package with the Simulink application. Using income data of functioning metallurgical complex CherMK of PJSC “Severstal”, the authors carried out the analysis of voltage quality of 10 kV network using specialized passive filters and without them. The article presents the results of the study of the effectiveness of the use of specialized passive filters in the in-plant power supply system of the rolling complex operating at the CherMK of PJSC “Severstal”. The reasons of the deterioration of the voltage quality in the 10 kV distribution network are studied, and as a result, operational breakdown of the modes of sensitive electrical receivers. A complex mathematical model of the 10 kV network has been developed to study the way to improve the harmonic composition of voltage due to installation of specialized passive filters. This filter allows you to adjust the frequency characteristics of the 10 kV network, shift it to an area free of high-frequency harmonics generated by modern frequency converters with active rectifiers. Thus, the resonance of currents and voltages in 10 kV sections is eliminated. As a result, a significant improvement in the shape of the line voltage and a decrease in the harmonic distortion coefficient of voltage THDU = 75,2–91,2 % to values THDU = 0,49–1,4 % is observed. The main result of the research is the recommendation to use a specialized passive filter to eliminate the negative impact of the harmonic component of the current resonance. The research results can be used to design power supply systems of metallurgical enterprises that have powerful electric drives with active rectifiers.
Model-based programming as a technique of electromechanical engineer
Authors:   LLC, Research and Development Company “Rubicon – Innovation”, Polyuschenkov I.S.
Published: March 2023

Modern electric drives with microprocessor control are complex technical systems with software that ensures the coordination of various physical processes for automatic motion control. At the same time, electromechanical engineers have a little knowledge about modern microprocessor technology, expressive and convenient programming languages, as well as modern software development and debugging technologies. Thus, it is difficult for them to develop electric drives independently. In addition, there is a professional gap between electromechanical engineers and programmers, which keeps them from cooperation on the software of electric drives. Nowadays, there are model-based programming tools designed to develop software in graphical form with a description of the built-in microcontroller modules in the form of configurable model blocks. However, the theoretical and practical issues of this technology are still limited and require development. Thus, the aim to develop model-based programming as a full-fledged technology for control systems development is relevant. Electromechanical engineers, on the one hand, and software developers, on the other hand, are the target of the research using the method of system analysis of professional competencies. The importance of the software for the electric drive microprocessor control systems is considered. The author assesses the capabilities of an electromechanical engineer who has been trained as a bachelor and master’s degree student in the field of “Electric Power and Electrical Engineering” as a developer of microprocessor-controlled electric drives. The author describes the model-based programming technique as an effective technology to develop software for microprocessor control systems intended for engineers of different spheres, including electromechanical engineers, whose activities are related to the development of electric drives. The author suggests an approach based on the application of model-based programming technology to develop microprocessor control systems for electric drives. The approach makes it possible to improve the competence of electromechanical engineers in the field of software development of control systems. Model-based programming technique contributes to the development of modern microprocessor technology and development technologies as an effective tool for independent development of software of electric drive systems by electromechanical engineers without assistance of programmers.
A Flexible Probability Model for Proportion Data: Unit Gumbel Type-II Distribution, Development, Properties, Different Method of Estimations and Applications
Authors: Shafiq Anum , Sindhu Tabassum Naz , Hussain Zawar , Mazucheli Josmar , Alves Bruna
Published: March 2023

In explaining and forecasting real life scenarios, statistical distributions are very helpful. It is very important to select the best fitting statistical distribution for modelling data. In analysis of real world phenomena like in reliability and economics, we may finddistributions for bounded data observed as percentages, proportions or fractions (see, for example, Marshall and Olkin (2007)). In this context, in view of pertinent transformation on the Gumbel Type-II model, we suggest and study the unit Gumbel Type-II (UG-TII)model and explore few of its statistical characteristics. We also consider various methods of estimating the unknown parameters of UG-TII model from the frequentist perspective. Monte Carlo simulations are worked out in order to compare efficiency of suggestedestimation methods for small as well as large samples. The efficiency of estimators is measured using simulated samples in terms of their bias and mean square error. In the end, two datasets have been examined in attempt to validate the realistic possibilities ofnew model. In comparison to the six severe competitors.
INFORMATION COMPONENT OF RUSSIA’S HYBRID WAR AGAINST UKRAINE
Authors:   Taras Shevchenko national University of Kyiv, Sashchyk Hanna , Rykhlik Volodymyr ,   Kyiv National Economic University named after Vadym Hetman, Ukraine
Published: March 2023

The informational component of the “hybrid war” used by the Russian Federation against Ukraine is considered. The components of information warfare, subjects and forms of hybrid warfare are substantiated. Priorities for the formation of an effective system for ensuring information security of Ukraine have been determined. It is noted that the information policy should contribute to the formation of the national information space, integration into the world information space and the formation of a democratically oriented consciousness. One of the main tasks of the information policy of the state is the creation of the necessary economic, legal, social, organizational mechanisms for the formation, development and effective use of national information resources in all spheres of life. It is summarized that the hybrid war unleashed by the Russian Federation against Ukraine is not only a challenge to the existence of an independent Ukrainian state. Danger threatens the entire system of international and European security. This leads to the destruction of the existing security architecture, the discrediting of its main structures, such as NATO, the EU, the OSCE, the UN Charter and the Helsinki Process regarding the inviolability of borders and state sovereignty. Russia, destroying the world order and generating global chaos in the international environment, claims a gradual and steady resto ation of Russian influence and significance on the international arena. And the Western world is gradually beginning to realize the threat of Russia’s geopolitical revenge. Ukraine, as well as the entire democratic world, should respond to the enemy’s aggression in a timely and adequate manner.
FEATURES OF GOVERNMENT FUNCTIONING IN THE MODERN PEOPLE’S REPUBLIC OF CHINA
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Petrenko Viktoriia
Published: March 2023

The article highlights the peculiarities of the organization and functioning of government in the modern People’s Republic of China. The formation and activity of central and local authorities, features of the electoral system and the role of the Communist Party in the administration of the PRC are considered. It was found that all local authorities (people’s assemblies and executive bodies) are part of a single vertical of power under the leadership of the National People’s Congress (parliament) and the State Council (government). In turn, both central and local authorities are under the supervision of committees of the Communist Party of China at various levels. At the same time, the party’s control is the tightest in the central authorities, the highest echelons of local authorities, and much weaker on the periphery in the lower echelons of local authorities. It was revealed that the positions of head of state, general secretary of the CPC, and chairman of the Central Military Commission are in the hands of one person (currently Xi Jinping), who actually has power over the country. At the same time, there is an agreement that at the local level party and state positions should be separated. In general, the system of managing society in the PRC is built in such a way that the party works in parallel with the state and is woven into all levels of state power. It has been established that elections in the PRC take place only at the local level, not at the national level, and their competitiveness is limited by the CCP’s monopoly on power and government interference in elections. There are no freely elected national leaders in China.
Ukraine expert analysis of the religions existence of Ukraine. Reviev on the book: Krysachenko V.S, Figurine Yu.S, Chirkov O.A. Ukrainian Christianity: establishment of identity. Gonceptual essays / MES of Ukraine; RIUS; Krysachenko V.S. (Project Manager, scientific editor), Kyiv. RIUS, 2022. 404 s.
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Khylko Mykola
Published: March 2023

In the second half of 2022, Valentyn Krysachenko, Yuriy Figurnyi, and Oleh Chirkov published a scientific work "Ukrainian Christianity: Affirming Identity. Conceptual Essays" was published. This important Ukrainian monograph was prepared for the research work "Humanitarian priorities of consolidation of Ukrainian society: social and value dimensions" (state registration number 0120U102058 (term of execution 01.01.2020-31.12.2022). ), which is being carried out at the Research Institute of Ukrainian Studies of the Ministry of Education and Science of Ukraine (hereinafter - RISU), headed by Doctor of Philosophy, Professor, Honored Worker of Science and Technology of Ukraine, Head of the Department of Military and Patriotic Education of RISU, V. Krysachenko.
Обзор категории «цель» в психологии
Authors: Васёв Роман Владимирович
Published: March 2023

В статье представлен обзор категории «цель» с психологической точки зрения, раскрывается состояние исследования целей в настоящее время. Обобщены результаты порядка 60 источников, включая эмпирические исследования целей. Предпринимается попытка собрать определения цели и обобщить их в виде единого конструкта. Показаны структура и свойства целей, отношения между средствами и целями, иерархия целей и подцелей, взаимосвязь между целями и планами, процессы постановки и достижения целей. Внимание уделяется конфликту целей и распределению ресурсов между несколькими целями, модели T.O.T.E., модели фаз действия «Рубикон», теории разворота М. Аптера, концепции психологической дистанции до цели, теме целенаправленного поведения с кибернетических позиций.

Также в статье рассмотрены различные типы целей, функциональная автономия мотивов и стратегии саморегуляции в достижении поставленных целей. Установлено, что намерения по реализации планов оказывают благотворное влияние на достижение цели благодаря автоматическим процессам, стремление к достижению цели может быть активировано бессознательно благодаря стимулам внешней среды.
Water and its importance for human life and health
Authors: Lunegova Irina V. , Tyts Valery V. , Lopatin Stanislav A.
Published: March 2023

Life is the most valuable asset that a person has. Throughout the time allotted to him, he seeks the meaning of his existence, makes plans, strives to implement them, creates and creates. And the main task of a person is to preserve this life, because it is priceless. Scientists have long established a direct link between the quality of drinking water and life expectancy. The rapid growth of the planets population in combination with increasing water consumption for household and industrial needs, agriculture leads to a global water crisis, which is manifested in a shortage of fresh water and its increasing pollution. In many countries, the question of providing the population with good quality drinking water is very acute, it has long been a subject of trade. The generally accepted scientific views on the role and importance of water for life and health, the main approaches to determining its quality in everyday human activities are revealed in this article.
Molecular mechanisms of transport of substances across the blood-brain barrie as targets for pharmacological action. Part 2. Modern methods of delivery of pharmacological agents to the central nervous system
Authors: Litvinova Maria V. , Trofimov Alexander N. , Shabanov Petr D. , Lebedev Andrei A. , Bychkov Evgeny R. , Arseniev Nikolay А. , Tyukavin Alexander I.
Published: March 2023

One of the unresolved problems on the way to improving the pharmacotherapy of CNS diseases is the development and creation of technologies that allow drugs to cross the blood-brain barrier (BBB). The review discusses modern methods of drug delivery to the CNS. The advantages and disadvantages of the main pharmacological strategies for directly overcoming the BBB and an alternative to this are shown. New methods of drug delivery to the brain with damage (physical, chemical, etc.) and without disruption of the blood-brain barrier structure (small molecules, cell-mediated transport, stem cells) are considered. The prospects for the use of artificial nanosized drug transporters are discussed. An alternative strategy of pharmacological action on the CNS structures (intranasal route) is shown to be promising. Possible mechanisms of action of pharmacological agents on CNS structures bypassing the BBB are considered.
Some theoretical and experimental aspects of surface waves for elastic constant determination
Authors:   , Huang Yimei , Rose Joseph L.
Published: March 2023

This thesis discusses the utility of surface waves for the determination of effective elastic constants of anisotropic materials. Theoretical analysis of surface wave propagation in anisotropic materials is presented. Computer software to calculate the velocities of surface waves on an arbitrarily oriented free surface of a generally anisotropic material is developed. The dependence of the surface wave velocities on the variations of the elastic constants of the materials and the azimuthal angles of the propagation is studied. An ultrasonic technique which combines measurements of bulk waves, subsurface longitudinal waves, and surface waves to determine the elastic constants of materials with monoclinic, orthotropic or transversely isotropic symmetry is investigated. A computer aided evaluation (CAE) system is proposed to offer an alternative method to a non-linear curve fitting algorithm to convert the surface wave measurement data to a partial set of elastic constants of a material. The CAE system is applied to the evaluation of CCSS material with columnar grain structure. The effect of experimental error on the reconstruction of elastic constants with respect to bonds of elastic constants for the stability study of the CAE system is demonstrated on a synthetic set of data. Sample measurement protocols on the determination of elastic constants of transversely isotropic and orthotropic materials from one-sided access wave measurements are summarized and discussed. Finally, a finite element method is suggested for further studies of and insight into surface wave propagation, especially involving material inhomogeneities.
Elimination of Misconceptions about Percentages with the Cognitive Conflict Approach
Authors: GÜLER OKUMUŞ Merve , GÜVELİ Ebru
Published: March 2023

This research aimed to eliminate the misconceptions about percentages with the cognitive conflict approach. The sample of the research consists of 10 students studying in the 8th grade of a public school in the central district of Rize/Turkey in the 2020-2021 academic year. In the study, in which the action research method was adopted, a misconception diagnosis test was developed by conducting a pilot study. In the light of the data collected after the pretest was applied, a lesson plan was prepared in accordance with the stages of the cognitive conflict approach and the application lasting four lesson hours was carried out with the students. The posttest was administered 2 weeks after the application. Data collection tools are two-stage diagnostic test, reflective diaries and video recordings. According to the findings, it was observed that the misconceptions of some students were eliminated, and the misconceptions continued in a student.
Öğrencilerin Telefonsuz Kalma Korkusunu (Nomofobi) İnceleyen Çalışmaların Sistematik Bir Analizi
Authors: AYDIN Mehmet Kemal , KUŞ Metin
Published: March 2023

Bu çalışmada, nomofobi kavramını ele alan, YÖK Ulusal Tez Merkezi ile TRDizin veri tabanlarında taranan ve 2016-2021 yılları arasında yayımlanmış tez ve makale çalışmalarının sistematik analizi gerçekleştirilmiştir. Sistematik analize dahil edilen çalışmalar; amaçlar, yöntemler, ana değişkenler, örneklem ve ölçme araçları açısından incelenmiştir. Bu amaçla, mevcut çalışmada Sistematik Analiz ve Meta Analizler için Tercih Edilen Raporlama Protokolünün (PRISMA) ilkeleri takip edilmiştir. Tanımlanan 67 çalışmanın 36'sı dahil edilme kriterlerini karşılamış ve sistematik analiz bu çalışmalar üzerinden gerçekleştirilmiştir. Analiz sonucunda, çalışmaların özellikle nomofobi yaygınlığını belirlemeyi amaçladığı, bunun için araştırmacıların daha çok nicel araştırma yöntemlerine başvurdukları ve çalışmalarda ağırlıklı olarak üniversite öğrencilerinden oluşan örneklem gruplarından veri topladıkları ortaya çıkmıştır. Ayrıca incelenen çalışmalarda, nomofobi ile kişilik, kaygı, stres, fiziksel veya zihinsel sağlık ve akademik başarı arasındaki ilişkilerin irdelendiği ortaya çıkmıştır.
A Sociogenomic Analysis of Chronic Wounds
Authors: Sizemore Brandon , Singh Kanhaiya , Sen Chandan K.
Published: March 2023

Background/Objective: 8.2 million US patients are affected with chronic wounds, with costs ranging from $28.1-$96.8 billion. Increasing healthcare costs, population age, and chronic condition incidences pose immense threats to the healthcare system and patients struck with the burden of chronic wounds. A sociogenomic approach to investigating mechanisms of chronic wound formation at the genomic level could provide a better understanding of how environmental factors and social demographics impact the development of such wounds. Our goal was to explore possible associations between outcomes of chronic wounds, healing status, genotype, gene expression, and the role of social demographics.
Experimental Design: DNA and RNA were isolated from blood samples obtained from 51 patients with chronic wounds. Participant demographics and health information was collected for analysis. iPLEX® and MassARRAY® systems were used to genotype ten SNPs of seven genes involved in wound healing. Quantification of gene expression was performed via RT-qPCR. T-test analysis, ANOVA, and Fisher’s Exact test were used for statistical analysis of results.
Results: Significant relationships were discovered between increased VDR expression with heart disease, peripheral vascular disease (PVD), and hypercholesterolemia/hyperlipidemia. TT genotype of rs1544410 present in vitamin D receptor (VDR) gene was associated with increased VDR expression as compared to CT genotype. Furthermore, increased methylenetetrahydrofolate reductase (MTHFR) gene expression was associated with PVD. Finally, the CC genotype of rs2274976 present in MTHFR gene was associated with better wound outcome than the CT genotype.
Conclusion/Impact: This study is one of the first known to investigate the impact of environmental factors and demographics on gene expression in patients with chronic wounds. Our results indicate social environment and genotype can play a significant role in patient gene expression and wound outcome. Future studies with larger sample sizes are warranted to investigate additional demographic data and expression of other genes involved in wound healing.
Acknowledgements: This project was funded, in part, with support from the Indiana Clinical and Translational Sciences Institute funded, in part by UL1TR002529 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. In addition, this project was completed with support from the Center for Medical Genomics at Indiana University School of Medicine in processing genotypes using iPLEX® and MassARRAY® systems.
Breast Cancer Detection Using Image Processing and Machine Learning
Authors: Habeeb Zeyad Q. , Vuksanovic Branislav , Al-Zaydi Imad Q.
Published: March 2023

Different breast cancer detection systems have been developed to help clinicians analyze screening mammograms. Breast cancer has been increasing gradually so scientists work to develop new methods to reduce the risks of this life-threatening disease. Convolutional Neural Networks (CNNs) have shown much promise In the field of medical imaging because of recent developments in deep learning. However, CNN’s based methods have been restricted due to the small size of the few public breast cancer datasets. This research has developed a new framework and introduced it to detect breast cancer. This framework utilizes Convolutional Neural Networks (CNNs) and image processing to achieve its goal because CNNs have been an important success in image recognition, reaching human performance. An efficient and fast CNN pre-trained object detector called RetinaNet has been used in this research. RetinaNet is an uncomplicated one-stage object detector. A two-stage transfer learning has been used with the selected detector to improve the performance. RetinaNet model is initially trained with a general-purpose dataset called COCO dataset. The transfer learning is then used to apply the RetinaNet model to another dataset of mammograms called the CBIS-DDSM dataset. Finally, the second transfer learning is used to test the RetinaNet model onto a small dataset of mammograms called the INbreast dataset. The results of the proposed two-stage transfer learning (RetinaNet → CBIS-DDSM → INbreast) are better than the other state-of-the-art methods on the public INbreast dataset. Furthermore, the True Positive Rate (TPR) is 0.99 ± 0.02 at 1.67 False Positives per Image (FPPI), which is better than the one-stage transfer learning with a TPR of 0.94 ± 0.02 at 1.67 FPPI.
Plant Species Classification Using Leaf Edge Feature Combination with Morphological Transformations and SIFT Key Point
Authors: Thomkaew Jiraporn , Intakosum Sarun
Published: March 2023

This paper presents a new approach to plant classification by using leaf edge feature combination with Morphological Transformations and defining key points on leaf edge with SIFT. There are three steps in the process. Image preprocessing, feature extraction, and image classification. In the image preprocessing step, image noise is removed with Morphological Transformations and leaf edge detect with Canny Edge Detection. The leaf edge is identified with SIFT, and the plant leaf feature was extracted by CNN according to the proposed method. The plant leaves are then classified by random forest. Experiments were performed on the PlantVillage dataset of 10 classes, 5 classes of healthy leaves, and 5 classes of diseased leaves. The results showed that the proposed method was able to classify plant species more accurately than using features based on leaf shape and texture. The proposed method has an accuracy of 95.62%.
Effects of Visual Input Changes on Canal and Otolith- Dependent Vestibulo-Ocular Reflexes: A Review Study
Authors: Heravian Shandiz Javad , Mazloom Mahdi , Jafarzadeh Sadegh
Published: March 2023

Background and Aim: There is an integration between visual and vestibular systems. Changes in visual inputs can result in different changes in the Vestibulo-Ocular Reflex (VOR). This review study investigate the changes in VOR due to changes in visual inputs. In this regard, the effects of different conditions such as visual deprivation, changes in visual acuity, visual-vestibular conflict, and binocular vision dysfunction on VOR were assessed.
Recent Findings: Changes in visual inputs and visual-vestibular conflicts can lead to different changes in VOR.
Conclusion: The changes in VOR effects vary from slight to severe transformation dependent on the time course, severity and duration of changes in visual inputs.
Keywords: Vestibulo-ocular reflex; visual inputs; refractive errors; head impulse test
Development of the Persian Version of Dichotic Offset Measure and Evaluation of Its Psychometric Properties in Normal-hearing Children: A Pilot Study
Authors: Irani Reza , Fatahi Farzaneh , Farahani Saeid , Shomeil Shushtari Sahar , Jalaie Shohreh , Katz Jack
Published: March 2023

Background and Aim: Buffalo model consists of four Central Auditory Processing Disorder (CAPD) categories: decoding, tolerance-fading memory, organization, and integration. Integration is considered as the most complex category. The Dichotic Offset Measure  (DOM) provides valuable information about the organization and integration problems. The present study aimed to develop the Persian version of the DOM (P-DOM) and evaluate its psychometric properties in normal-hearing children.
Methods: In this study, 25 normal-hearing children (13 girls) aged 7–12 years participated and were divided into six age groups. The face validity was determined based on the opinions of 15 experts, five children with CAPD, and five normal-hearing children. All children were tested with the Persian staggered spondaic word test, Persian phonemic synthesis test, and the Persian randomized dichotic digit test.
Results: The results showed the high face validity of the P-DOM. No significant differences were observed between the scores of girls and boys (p=0.394 for the right non-competing, p=0.623 for the right competing, p=0.155 for the left competing, p=0.066 for the left non- competing, p=0.174 for the total score, and p=0.701 for the reversals). Significant differences were observed in the main scores of P-DOM test among the age groups. The Spearman test showed a high test-retest reliability (r>0.69).
Conclusion: As a preliminary study it seems that the P-DOM has good validity and reliability to be used in normal-hearing children, but it needs further research with larger sample size.
Keywords: Auditory processing; dichotic offset measure; dichotic listening; integration deficit
Effect of Online Unified Protocol for Transdiagnostic Treatment of Emotional Disorders on Emotion Perception of School-Aged Children with Cochlear Implant
Authors: Mehrdadfar Marzieh , Ghasemzadeh Sogand , Ghobari Bonab Bagher , Hasanzadeh Saeid , Vakili Samira
Published: March 2023

Background and Aim: Emotion perception means the ability to identify, predict and explain one’s own emotions and those of others. Less attention has been paid to the psychosocial effects of hearing loss such as emotion perception. The current study aimed to investigate the effect of the unified protocol for transdiagnostic treatment of emotional disorders on emotion perception of children with Cochlear Implant (CI).
Methods: This is a quasi-experimental study with a pretest/post-test/follow-up design. Participants were 18 children with CI aged 8–11 years and their mothers were randomly divided into experimental and control groups. All mothers and their children in the experimental group received the Unified Protocol (UP) program online at 20 sessions twice a week. For the evaluation of emotion perception, we used the Test of Emotion Comprehension (TEC) which had high internal consistency. For statistical analyses, descriptive statistics and repeated measures ANOVA were used.
Results: Mean score of emotion comprehension test at the mental and reflective levels and its overall score were significantly different between pretest and post-test and between pretest and follow-up phases in both group. The difference in the external level of emotion perception was not significant among three phases in any groups.
Conclusion: The UP program can positively affect the emotion perception in children with CI, especially in more difficult levels (mental and reflective), and its effects remain stable three months after the intervention.
Keywords: Emotion; children; cochlear implants; perception; transdiagnostic treatment.
Bilateral Superior Semi-Circular Canal Dehiscence Presenting as Conductive Hearing Loss with Vestibular Symptoms: A Client Centre Case Report
Authors: Rezvani Amin Mahmoud , Behzad Hadi , Kafashan Setareh , Kamrani Ali
Published: March 2023

Background: Superior semicircular canal dehiscence (SSCD) is a rare bone defect in the petrous part of the temporal bone. In this syndrome, a third window is created between the middle cranial fossa and the bony labyrinth of the inner ear which can lead to stimulation of the vestibular system by sound. Patients usually have symptoms such as vertigo, imbalance, autophony, pulsatile tinnitus, and aural fullness. The clinical symptoms of this disease vary from person to person.
The Case: This study reports a case of a rare bilateral SSCD in a 39-year-old woman with imbalance and autophony problems. The audiological findings showed a bilateral mild conductive hearing loss at low frequencies with symptoms of vertigo and torsional nystagmus. The SSCD was diagnosed by computed tomography. Then, the patient underwent bone repair surgery. Auditory and balance tests were performed again after the surgery to evaluate the extent of recovery.
Conclusion: The SSCD can be diagnosed by using the mentioned test battery. By choosing the appropriate treatment methods and following up of the outcomes, most of the problems of patients with SSCD can be solved.
Keywords: Superior semicircular canal dehiscence; bilateral; conductive hearing loss
Future of Telemedicine in Indonesia During Covid-19 Pandemic Era: “Literature Review
Authors: Fitrina Andiani Aditha , Widjaja Putra1 Bayu Taruna , Khoiri Abu
Published: March 2023

Context: Online health consultation services are developing, both website-based and application-based, better known as telemedicine or telehealth. Over 50% of the population can access health information easily. Telemedicine can expand healthcare services, increase accessibility, provide clinical support, save time and costs, and be efficient because it overcomes geographic barriers, offers a wide variety of communication tools, and improves patient care. Telemedicine is used to bring specialist, anti-discriminatory and effective health services closer to the interests and safety of patients to expand the quality services in healthcare centers, especially in rural areas in Indonesia.
Material and Methods: The study design used in this article is a narrative literature review or formal review by reading the references carefully, then making a summary, drawing conclusions, and finding gaps in the manuscript adapted to the topic to be discussed.
Results: The significant number of problems and challenges in public health services in Indonesia can provide exciting opportunities to develop an e-health system that can help solve problems. To put a stop, the Indonesian government is advising the public and medical professionals to use telemedicine as an online public health service application between hospitals and patients.
Conclusions: Telemedicine significantly correlates with government and start-up calls and can be employed as a health service option during the COVID-19 pandemic. In this pandemic, telemedicine can improve services in terms of monitoring, evaluating, and educating patients and medical staff.
COVID-19 Economic Impact on Health Sector, Challenges, and Practical Strategies
Authors: Habibi Farhad , Khosravi Bahman , Rajabi Vasokolaei Ghasem
Published: March 2023

The Article Abstract is not available.
Diagnosis, Prevention, and Control of Hypertension in Iran: A SWOT Analysis
Authors: Gholizadeh Masoumeh , Janati Ali , Khodayari-Zarnaq Rahim , Zakaria Pezeshki Mohammad , Basharic Fateme Arabi , Rafiee Noora
Published: March 2023

Background: Hypertension is one of the most important risk factors of cardiovascular morbidity and mortality that holds a unique place in population health and health care.
Objectives: Given the exponential rise of high blood pressure as one of the major health problems, this study aimed to investigate the current situation and provide a strengths, weaknesses, opportunities, and threats (SWOT) analysis in the management of hypertension
Methods: A qualitative study of 12 interviews was conducted with policymakers and managers. The sampling method was purposive sampling. Data collection was performed from January to July 2020. A thematic approach was used to analyze the data. The consolidated criteria for reporting qualitative research 32-item (COREQ-32) checklist was applied to ensure quality control in the study design, analysis, and data reporting.
Results: A total of 12 factors were identified as SWOT. The most important strengths included universal coverage of health services, provision of team-based care, and self-care training. The weaknesses were related to the therapeutic approach, long-term planning, and continuity of programs. Cooperation of other sectors with the health system and the existence of health management training centers were noted as opportunities to better implement hypertension management programs and confront threats such as conflicts of interest between guilds and organizations and crises.
Conclusions: High blood pressure can be prevented. The present direction toward health-oriented policies can be changed in all sectors by taking advantage of the existing strengths and opportunities.