bluuebunny/crossref_metadata_2025 huggingface dataset:
APPLICATION OF CONTEXTUAL TEACHING AND LEARNING MODEL (CTL) TO IMPROVE READING UNDERSTANDING ABILITY
Authors: Suwardini Tri Diani , Sulastri Lilis , Altaftazani Deden Herdiana
Published: June 2022

Reading is a very important language skill. Because by reading someone can increase knowledge. But in its implementation in school there are still many obstacles. Based on the results of research that students' reading ability in schools is still relatively low. Another problem in reading learning, which needs to be thought by all parties is the problem of competence and creativity of the teacher in compiling reading learning materials. Because the development of learning materials is very important in motivating student learning. Teachers must be able to compile learning materials that are appropriate to the conditions of the student's own environment. Contextual learning materials will motivate students in learning. The main problem in this study was "Application of the Contextual Teaching and Learning (CTL) Model in Reading Learning to Improve Reading Comprehension Ability in Grade IV Students of SDN 165 Bandung City Trainings 2017/2018 Academic Year. In this study the authors used descriptive methods. Using instruments interview research, observation, observation, and tests. The purpose of this study was to determine the success of the Contextual Teaching and Learning Model (CTL) in Grade IV Students of SDN 165 trainings in reading comprehension learning. In this study the authors used Classroom Action Research (CAR) using 2 Cycles. After the data is collected, the writer analyzes, calculates the average, and presents the results. Based on the results of the study the authors conclude, that learning to read comprehension by applying Contextual Teaching and Learning (CTL) results is very good. Hi, this is proven if the average pre-test results only reach 4.60 or 46% of students understand the content of the reading. After being implemented in the first cycle there was an increase, namely the average value of the test post reached 7.20 or 72%. While the results of the post cycle II test reached an average value of 8.20 or 82%. Thus, when compared to the results before using the model and after using the Contextual Teaching and Learning Model (CTL) there is a very significant increase seen from the average value and percentage.
PENTINGNYA KUALITAS PRIBADI KONSELOR DALAM PELAKSANAAN KONSELING INDIVIDUAL
Authors: Haolah Siti , Atus Atus , Irmayanti Rima
Published: June 2022

Konselor sebagai sebuah profesi sudah pasti memiliki standar kualitas. Salah satu kualitas konselor adalah kualitas pribadi konselor. Kualitas pribadi konselor khususnya di Indonesia mencakup: (1) beriman dan bertakwa kepada Tuhan yang Maha Esa; (2) menghargai dan menjunjung tinggi nilai-nilai kemanusiaan; (3) menunjukkan integritas dam stabilitas kepribadian yang kuat; dan (4) menampilkan kinerja berkualitas tinggi.Konseling individual merupakan kunci semua kegiatan bimbingan dan konseling. Proses konseling individual merupakan relasi antara konselor dan konseli dengan tujuan agar dapat mencapai tujuan konseli. Tujuan utama dari konseling individual adalah pengentasan masalah konseli, sehingga konselor memiliki tanggung jawab membantu konseli dalam pengentasan masalah tersebut dengan menggunakan keterampilan dan pendekatan dalam konseling melalui tahapan-tahapan proses konseling. Kualitas pribadi konselor dalam proses konseling individual merupakan titik tumpu antara pengetahuan dan keterampilan dari konselor. Dengan kata lain keberhasilan atau keefektifan dalam proses konseling dipengaruhi oleh kualitas pribadi konselor dalam melakukan teknik atau keterampilan dalam setiap tahap peroses konseling.   Kata kunci : Kualitas pribadi konselor, konseling individual
MEMBANGUN RASA EMPATI MELALUI TEKNIK SOSIODRAMA PADA SISWA SMP & SMA
Authors: Putra Muhammad Fajar Sidik Jamaludin , Daffa Muhammad , Zakhullu Stefanus Fati
Published: June 2022

Empati adalah kemampuan untuk membayangkan apa yang mungkin dirasakan atau dipikirkan oleh orang lain dan juga kemampuan untuk merasakan kemampuan orang lain. Tujuan Penelitian ini adalah meningkatkan rasa empati siswa melalui layanan bimbingan dan konseling teknik sosiodrama. Metode penelitiannya dengan menganalisis beberapa jurnal yang sudah ada agar mendapatkan beberapa metode yang bisa dipakai Guru BK ketika mengajar. Hasil penelitian menunjukkan bahwa teknik sosiodrama secara statistik dapat secara efektif membangun rasa empati pada siswa dengan jenjang dunia pendidikan SMP dan SMA berdasarkan dari beberapa penelitian yang di ungkapkan sebelumnya Kata Kunci : Sosiodrama, Empati
GAMBARAN MOTIVASI BELAJAR SISWA YANG MENGALAMI BROKEN HOME
Authors: Kartini Iis Islami , Listiawaty Tiara N , Rosita Tita
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui gambaran motivasi belajar siswa yang mengalami broken home pada siswa-siswi SMP Negeri 1 Arjasari. Terjadinya broken home pada siswa akan sangat berpengaruh bagi motivasi belajarnya. Ini dikarenakan banyak sekali siswa yang malas untuk belajar, bahkan melakukan hal kecil seperti membuka kembali pelajaran yang sudah dipelajari sudah jarang sekali dilakukan oleh siswa. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan jenis penelitian deskriptif yang bersifat studi kasus. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa lima siswa SMP Negeri 1 Arjasari memiliki motivasi belajar yang tinggi, namun satu dari ke enam siswa memiliki motivasi yang rendah dalam belajar.
GAMBARAN PERENCANAAN KARIER SISWA SMP
Authors: Rosmana Fera Hertiani , Wikanengsih Wikanengsih , Suherman Maya Masyita
Published: June 2022

Career planning is a process by which individuals can identify and take steps to achieve their career goals. Junior high school students in general have not been able to make good career plans, they do not have much information about careers, be it about secondary school or specialization in education and also work. The purpose of this study is to describe the description of junior high school student career planning. This research uses descriptive qualitative method. The subjects of this study were two students related to career planning at MTs Sirnamikin. The data collection techniques of this research were interviews and direct observation through school observations. The results showed that the potential and abilities of each student were different. Students must learn to consider and find a variety of information about the career they want. And so that all of this can materialize as they expect, therefore a good career planning is needed. Keywords: Career Planning, Middle School Students
BIMBINGAN KELOMPOK DENGAN TEKNIK ROLE PLAYING UNTUK MENGURANGI PERILAKU BULLYING PADA PESERTA DIDIK SMP “X” DI KOTA BANDUNG
Authors: Adit Ganjar Nugraha , Hendriana Heris , Rosita Tita
Published: June 2022

Penelitian ini bertujuan untuk menerapkan metode role playing dalam mengurangi perilaku bullying pada peserta didik kelas VIII di SMP “X” Bandung Tahun Pelajaran 2019-2020. Penelitian ini merupakan penelitian quasi eksperimen dengan jenis penelitian pretest-posttest control group design. Jumlah populasi dalam penelitian ini adalah 100 peserta didik, dan sampel penelitian menggunakan teknik purposive sampling. Setelah diidentifikasi, maka jumlah sampel yang ada sebanyak 24 peserta didik di kelas VIII A. Selanjutnya dari 24 Peserta kelas VIII A dibagi menjadi dua kelompok yaitu 12 peserta didik sebagai kelompok eksperimen dan 12 siswa sebagai kelompok kontrol. Teknik pengumpulan data menggunakan angket perilaku bullying. Sebelum mendapatkan perlakuan, dari total 83 peserta didik kelas VIII didapatkan sebanyak 6 peserta didik dengan tingkat bullying tinggi, 59 sedang, dan 18 rendah. Kemudian setelah diberikan perlakuan pada kelompok eksperimen sebanyak 6 sesi, maka terjadi penurunan tingkat bullying yang lebih signifikan dibandingkan dengan kelompok kontrol. Hasil rata-rata skor pre-test kelas eksperimen mengalami penurunan dari semula 94,83 menjadi 75,6 pada saat post-test. Sementara kelas kontrol hanya mengalami sedikit penurunan dari semula 76,41 menjadi 75,1. Dengan melihat Sig. (2-tailed) kelas eksperimen yaitu 0,000 < 0,05 maka Ho ditolak dan Ha diterima, sehingga dapat disimpulkan bahwa ada perbedaan rata-rata antara hasil pre test dengan post test yang artinya ada pengaruh dalam penerapan bimbingan kelompok dengan teknik role playing dalam mengurangi perilaku bullying pada peserta didik kelas VIII di SMP “X” di kota Bandung.Kata Kunci Bimbingan Kelompok, Role Playing, Bullying.
LAYANAN BIMBINGAN PRIBADI PADA SISWA SMA NEGERI 4 CIMAHI YANG MEMILIKI CITRA TUBUH RENDAH
Authors: Hidayat Riska , Julaeha Siti
Published: June 2022

Tujuan dari penelitian ini yaitu untuk mengetahui efektifitas layanan bimbingan pribadi untuk siswa yang memiliki citra tubuh yang rendah. Metode yang digunakan yaitu metode kualitatif dengan pendekatan studi kasus. Sampel penelitiannya yaitu dua siswa kelas X SMA Negeri 4 Cimahi yang memiliki citra tubuh yang rendah. Teknik pengkumpulan data dengan  yaitu menggunakan teknik wawancara dan observasi. Berdasarkan hasil wawancara dan observasi diperoleh kesimpulan bahwa layanan bimbingan pribadi pada dua siswa yang memiliki citra tubuh yang rendah cukup efektif dan memberikan dampak positif yang cukup signifikan. Kata kunci: Kecemasan, Bimbingan Pribadi.
LAYANAN BIMBINGAN PRIBADI-SOSIAL UNTUK SISWA YANG MEMILIKI SELF-EFFICACY RENDAH
Authors: Rahmani Nur , Rosita Tita
Published: June 2022

Bimbingan pribadi-sosial merupakan salah satu pilihan layanan dalam pelaksanaan layanan bimbingan konseling untuk siswa dalam membantu menentukan dan mengembangkan dirinya secara optimal dan mandiri sesuai dengan kewajibannya sebagai makhluk Tuhan. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan jenis penelitian studi kasus. Tujuan penelitian ini yaitu untuk mengetahui bagaimana pelaksanaan bimbingan pribadi-sosial untuk anak yang memiliki self-efficacyrendah. Teknik pengumpulan data yang digunakan adalah wawancara, dan dokumentasi. Hasil penelitian menunjukan pelaksanaan layanan bimbingan pribadi-sosial di MTs YPIA Cikeris terdiri dari 4 tahap, yaitu tahap perencanaan, tahap pelaksanaan, tahap evaluasi dan tindak lanjut. Bentuk layanan bimbingan pribadi-sosial untuk mengembangkan self-efficacy yang rendah yaitu dengan metode bimbingan tidak langsung dan metode bimbingan langsung adapun materi yang disampaikannya yaitu motivasi, percaya diri, harga diri, penyesain diri dan mengontrol emosi. Hasil penelitian menunjukan siswa yang memiliki self-efficacyrendah perlahan dapat menentukan dan mengembangkan kemampuan dirinya dalam lingkungan sosialnya di sekolah. Kata Kunci: Bimbingan Pribadi-Sosial, Self-efficacy.
GAMBARAN TINGKAT KESADARAN KEDISIPLINAN SISWA SMP NEGERI 4 CIPEUNDEUY
Authors: Pitriani Peti , Hendriana Heris , Supriatna Ecep
Published: June 2022

Discipline is a condition in which all students understand and are aware of compliance with the rules in the school, as the technology of the student's behavior towards school rules begins to shift to a decrease in student awareness of obeying school rules. This research aims to find out the picture of students' awareness of discipline at SMP Negeri 4 Cipeundeuy. The approach used in this study is a qualitative approach with descriptive methods and types of phenomenological research. The data collection technique used is interview. The results of the study revealed that the low awareness of the school rules is because students can not control themselves against the negative influence of the surrounding environment among others; friendship with an environment that is not already in school, students feel that clothes that comply with the school rules are considered incompatible with their character/ geeky, home environment that is not conducive because of parental quarrels that make students fight also in school.  Keywords: : Student awareness, Discipline.
PROFIL MOTIVASI BELAJAR SISWA WITHDRAWAL SMPN 1 SUCINARAJA
Authors: Nurbaeti Anne , Wikanengsih Wikanengsih , Rosita Tita
Published: June 2022

The purpose of this study was to determine the profile of students' motivation withdrawal at SMPN 1 Sucinaraja. Students withdraw or break away are students who show escape, both attention or interest in the social environment. The sampling technique in this study used a nonprobability sampling technique with a sample of 51 students. Researchers interested of SMPN 1 Sucinaraja. Based on the results of the study It is expected that students' motivation in SMPN 1 Sucinaraja is in the medium category with the distribution of students 2% withdrawal has a very low motivation to learn, 33% of students who have learning withdrawal by learning in the low category, 29% of orangutans who have the ability to learn in the medium category, 35% of school people have the motivation to learn in the very high category and none of the students who have the motivation to learn the category is very high. Of the four aspects of learning motivation used in data mining, the aspect of confidence is the lowest aspect of student motivation in withdrawal at SMPN 1 Sucinaraja.Keywords: Learning motivation, Withdrawal Students of SMPN 1 Sucinaraja.
VALIDITAS DAN RELIABILITAS ANGKET PENYESUAIAN DIRI PESERTA DIDIK SMA
Authors: Tussaadah Rizqi Zamilah , Hendriana Heris , Yuliani Wiwin
Published: June 2022

Self-adjustment is an individual's effort to achieve harmony with himself and his environment, so that feelings of hostility, envy, jealousy, prejudice, depression, anger and negative emotions as inappropriate and inefficient personal responses can be eroded out. From this understanding, self-adjustment is a natural and dynamic process that aims to change individual behavior so that there is a relationship that is more appropriate to the conditions of the environment. Seeing how important self-adjustment is for individuals even for students in new environments, a measuring tool is needed in the form of an self- adjustment questionnaire. This study uses research and development (R&D) development research to develop and validate educational products in the form of an self-adjustment questionnaire. The self-adjustment questionnaire required validity and reliability tests. The subjects of this study were students of SMA Negeri 1 Cipongkor. The results of the validity test of the self-adjustment questionnaire stated that 13 statements were valid and their reliability was 0.718 which was categorized as high from the 30 statements that the researcher made from 28 respondents.Keywords:  Self-Adjustment, Validity, Reliability
GAMBARAN KEJENUHAN BELAJAR SISWA SMK KELAS X
Authors: Rosmaidah Siti , Supriatna Ecep , Irmayanti Rima
Published: June 2022

The saturation of learning has a big impact on the decrease in learning motivation of learners. Students who initially do not know the symptoms of learning saturation may consider the learner to be lazy to learn.  But the saturation of learning that students experience can result in decreased test scores and assignments, not following the KBM process, can even ditch the school because it feels lazy. This study uses a qualitative approach. The data collection conducted are interviews and observations. The results of the study indicate that the sense of boredom in learning experienced by students is that they lack support from themselves, outside themselves and in a bad environment, thus making them lazy to take part in learning. Keywords: saturation of learning,  students
KONSEP MOTIVASI BELAJAR SISWA KELAS X SMA DI MASA PANDEMI COVID-19
Authors: Rahmania Rizka , Hendriana Heris , Siddik Riesa Rismawati
Published: June 2022

The Covid-19 virus has changed the procedures of civilization in Indonesia, especially during the learning process. Changes in the learning process will have an impact on face-to-face and other learning modes, as well as on learning motivation, because it is certain that students can feel bored when studying online at home. This study aims to confirm the learning motivation of SMA Negeri 4 Cimahi or the concept of student learning encouragement during the COVID-19 outbreak. This study uses a qualitative description system. The data collection methods that I used in this study were interviews and recording. The results showed that this study was conducted on four students of SMA Negeri 4 Cimahi whose learning motivation is still very low, the signs include: family conditions, learning abilities, student conditions, monotonous learning, lack of motivation to learn, and teachers teaching.  Keywords: concept motivation, pandemic covid-19
VALIDITAS DAN RELIABILITAS ANGKET MOTIVASI BERPRESTASI
Authors: Al Hakim Riko , Mustika Ika , Yuliani Wiwin
Published: June 2022

Achievement motivation has an important role in education, besides acting as an encouragement for students to achieve optimal achievement, achievement motivation also plays a role as a determinant of learning outcomes and student learning achievements. Therefore, it is necessary to measure achievement motivation in the form of a achievement motivation questionnaire that has gone through the validity test stage and the reliability test stage. The subjects in this study were students of SMK 01 Cipongkor class XII totaling 20 students. From the results of the validity test of 38 statements there are 30 questions that are declared valid and the validity test gets a value of 0.941 which means it is included in the very high category. Thus the achievement motivation questionnaire can be used as a tool to measure the level of achievement motivation of students. Keywords:  Achievement Motivation,  Validity and Reliability
VALIDITAS DAN RELIABILITAS ANGKET RASA EMPATI
Authors: Komarudin Ranayuda Fujiansyah , Rohaeti Euis Eti , Yuliani Wiwin
Published: June 2022

Empathy is a person's ability to understand and place a position in accordance with the feelings of others. A student must have empathy to be more sensitive to the surrounding environment. The purpose of this study was to determine the sense of empathy in class VIII MTSN 3 Purwakarta using a questionnaire. The method in this research is to use research and development. This method is used to create a product, as well as to test the effectiveness of a product. The sample in this study was the students of class VIII at MTs Negeri Purwakarta as many as 23 students. The research instrument used was a questionnaire containing 6 tests of the characteristics of empathetic people. Analysis of the data used is testing the validity and reliability of SPSS assisted. The results of the study found that 23 statements were valid because the results of the calculation of rcount were more than rtable. The reliability test showed that Cronbach's Alpha coefficient value was 0.788 so it was declared reliable in the high category so that the questionnaire was reliable. Thus this questionnaire can be used to measure students' empathy. Keywords:  Empathy, Validity, Reliability
STUDI DESKRIPTIF TERHADAP REGULASI EMOSI PADA SISWA KELAS IX DI SMP NEGERI 2 PAKISJAYA
Authors: Nuz'amidhan Rizky Lazuardi , Supriatna Ecep , Pahlevi Reza
Published: June 2022

Emotion is a volatile state in an individual that functions or acts as an internal adjustment to the environment to achieve individual well-being and safety. Emotion regulation is the ability of students to control, evaluate and modify their emotions. Students who have high or stable and normal emotional regulation are able to regulate their emotions and can express emotions in accordance with the norms and circumstances of the surrounding environment.The method used is a descriptive method with a quantitative approach and the subjects in this study were students of SMP Negeri 2 Pakisjaya Determination of the sample size taken using the Slovin formula as many as 120 students. The sampling technique used in this study is Proportional Random Sampling, it is intended that each population in the class can represent. The results showed that the majority of students' emotional regulation were in the moderate category, amounting to 88 (73.33%), for the high category there are 12 (10%), and the remaining 20 (16.67%) are in the low category.It was concluded that the majority of the students of SMP Negeri 2 Pakisjaya were in the moderate category and had normal and stable emotional regulation. Keywords: : Emotional Regulation, Learners
LAYANAN BIMBINGAN KARIER BERBASIS ONLINE MELALUI TEKNIK DISKUSI KELOMPOK DALAM PENGAMBILAN KEPUTUSAN KARIER SISWA SMA
Authors: Dewi Lisnawati , Rohaeti Euis Eti , Irmayanti Rima
Published: June 2022

Career decision-making is the process of determining one of two or more choices related to intentional work/further education. This research aims to find out how the Implementation of Online-based Career Guidance Services through Group Discussion Techniques in career decision making, teacher and student response, student difficulties, as well as obstacles experienced by BK teachers regarding Online-based Career Guidance services through Group Discussion Techniques in career decision making. The method study qualitative descriptive. Data obtained from results research in  form words and explanations about a phenomenon that occurs. The subjects in this study were 1 BK Teacher, and 6 students of class XII Of State High School 1 Cisarua. The data collection procedure uses questionnaires, observations and interviews. Based on the results of research shows the findings in the field including students are not fully able to make career decisions well proven by the results of career decision making. There is only 1 student who has a career decision in the high category with a percentage of 17%, while 4 people with a moderate category with a percentage of 67%, and 1 person with a low category with a percentage of 17%. However, after being given career guidance services students find it helpful in their further education decision making. Keywords: Career Guidance, Group Discussion, Career Decision Making
TEKNIK ASSERTIVE TRAINING SECARA DARING UNTUK MENINGKATKAN SELF ESTEEM SISWA KELAS VII SMP NEGERI 2 SOREANG
Authors: Rahmatyana Nanin , Hendriana Heris , Siddik Riesa Rismawati
Published: June 2022

Self-esteem is a form of individual assessment of himself as an individual who has the ability, meaning, value and competence. Stepping on the transition period from elementary school to junior high school, every individual needs an adjustment to the new environment, one of which is that each individual must be able to show good behavior in the community, but if the individual has not been able to assess how far the individual assesses himself then will have an impact on the emergence of conflicts that come from within him and judge something irrationally which will have an impact on emotional disturbances that can affect his relationships with other people. The purpose of this study is that students are able to assess themselves, be able to socialize and be able to communicate well. This study uses descriptive qualitative by analyzing existing data by describing in detail. This study uses respondents totaling 6 seventh grade students at SMP Negeri 2 Soreang by looking at the results of observations that have been made tend to have self-esteem low. For this reason, it is necessary to provide BK services withtechniques assertive training for 3 meetings via video calls media WhatsApp which are supported by the results of interviews and observations showing changes from within students who are able to assess themselves, are able to think positively and can adapt well.Keywords: Assertive Training Techniques, Self Esteem
STUDI DESKRIPTIF SELF CONCEPT SISWA SMP NEGERI 1 BATUJAJAR
Authors: Azizah Fahdilla Noor , Supriatna Ecep , Pahlevi Reza
Published: June 2022

This study aims to describe the level of self-concept of students in SMP Negeri 1 Batujajar. The approach in this study is a quantitative approach with a descriptive method. Data collection in this study used an instrument in the form of the Tennessee Self Concept Scale (TSCS) of 100 statements adapted from previous research. The samples in this study were junior high school students in grades VII, VIII, and IX. The results showed that the self-concept of students at SMP Negeri 1 Batujajar was included in the medium category as many as 58 students with a percentage of 70% based on aspects of self-concept, namely identity, self-acceptance, behavior, physical, moral-ethical, personal, family, social, and social. self-criticism. Meanwhile, when viewed by gender, the moderate category is more dominant in female students as many as 54 students with a percentage of 65%. Based on age, the medium category which is more dominant in 14 year old students is 34 students with a percentage of 41%, and based on the category of the most dominant aspect, the medium category which is the most dominant in the family aspect is 56 students with a percentage of 76%. Keywords: : Self  concept, Junior High School Student
KONSELING INDIVIDUAL TEHADAP PEMILIHAN KARIER SISWA SMAN 1 BATUJAJAR
Authors: Kusumah Desi , Mustika R. Ika , Ayu ningrum Devy Sekar
Published: June 2022

Career selection is very important for students so that they know where they will continue after graduating from school, therefore there is a need for individual counseling or counseling for the maturity of students' career choices. The technique used in this individual counseling is client cantered, which is to provide guidance so that students can solve the problems they face. Researchers used two students as subjects in implementing individual counseling services withtechniques client centered , because not a few students had problems in the form of difficulties in determining secondary schools. The purpose of this study was to find out the implementation, response and constraints in the implementation of individual counseling usingtechniques client centered for students who have problems in determining careers. This study used a qualitative approach, and the data collection techniques used were observation, interviews and documentation. The results of the study indicate that individual counseling usingtechniques client centered can help determine the secondary school according to their wishes, talents and interests. After attending individual counseling services, students often seek information and ask questions about secondary schools.Keywords: : Career, Client Centered
Safety and Immunogenicity of 3 Doses of BNT162b2 and CoronaVac in Children and Adults with Inborn Errors of Immunity
Authors: Leung Daniel , Mu Xiaofeng , Duque Jaime Rosa , MS Samuel Cheng , Wang Manni , Zhang Wenyue , Zhang Yanmei , YS Issan Tam , SS Toby Lee , HY Jennifer Lam , Chan Sau Man , Cheang Cheuk Hei , Chung Yuet , HW Howard Wong , MT Amos Lee , Li Wing Yan , Chaothai Sara , CH Leo Tsang , Chua Gilbert T , Cheong Kai-Ning , Au Elaine , SY Janette Kwok , Chan Koon Wing , Chong Patrick , Lee Pamela , Ho Marco HK , Lee Tsz Leung , WW Tu , Peiris Malik , Lau YL
Published: June 2022

Background Safety and immunogenicity of 3 doses of BNT162b2 and
CoronaVac in adult and pediatric patients with inborn errors of immunity
(IEIs) remain unknown. Intradermal vaccination may improve
immunogenicity in immunocompromised patients. Our study (NCT04800133)
aimed to determine the safety and immunogenicity in patients with IEIs
receiving a 3-dose primary series of mRNA vaccine BNT162b2 (age 12+) or
inactivated whole-virion vaccine CoronaVac (age 3+) in Hong Kong,
including Omicron BA.1 neutralization, in a nonrandomized manner.
Intradermal vaccination was also studied. Methods Thirty-nine patients
were vaccinated, including 16 with homologous intramuscular 0.3ml
BNT162b2 and 17 with homologous intramuscular 0.5ml CoronaVac. Two
patients received 3 doses of intradermal 0.5ml CoronaVac, and 4 patients
received 2 doses of intramuscular BNT162b2 and the third dose with
intradermal BNT162b2. Adverse reactions and adverse events were tracked
for 7 and 28 days after each dose. Antibody responses assessed included
binding IgG antibody to wild-type (WT) spike receptor-binding domain
(S-RBD IgG) and surrogate neutralization activity to WT and BA.1
viruses. T cell responses were examined by intracellular cytokine
staining following stimulation with SARS-CoV-2 peptide pool(s). Results
No safety concerns were identified. Inadequate antibody responses were
found after 2 doses in patients with humoral immunodeficiencies and
especially so against BA.1. Dose 3 of either vaccine increased S-RBD IgG
response. T cell responses against SARS-CoV-2 antigens were detected in
vaccinated IEI patients. Intradermal third dose vaccine led to high
antibody response in 4 patients. Conclusions The primary vaccination
series of BNT162b2 and CoronaVac in adults and children with IEIs should
include 3 doses for optimal immunogenicity.
A rare case of SRD5A3-CDG in a patient with ataxia and telangiectasia: A case report
Authors: nabavizadeh hesam , Noeiaghdam Rafat , Johari Leila , Hosseini Seyed Ali , Esmaeilzadeh Hossein , Alyasin Soheila
Published: June 2022

SRD5A3-CDG (MIM 612379) is an extremely rare congenital disease, with
only 38 cases having been reported. Common manifestations are
developmental delay, intellectual disability, ophthalmological
abnormalities, cerebellar abnormalities, ataxia, and hypotonia. Here, we
discuss a seven-year-old boy with SRD5A3-CDG (homozygous variant
c.57G>A [p.Trp19Ter]), featuring the unprecedented
finding of telangiectasia.
Fatigue analysis in newly designed hip prosthesis by finite element method
Authors: KAYA Fatih , İnce Gülhan
Published: June 2022

Fatigue life estimation is one of the vital factors in the design of
biomedical prostheses. But fatigue tests of a hip prosthesis require
over ten million cycles, furthermore experimental methods may be too
expensive and take a long time for material selection or optimization.
Therefore, numerical analyses performed by Finite Elements Methods (FEM)
becomes necessary to pre-estimation of fatigue life. In this study, a
numerical analysis performed by FEM analysis to estimate the fatigue
performance of newly designed hip prosthesis. Prior to experimental
testing processes, aimed to analyze the candidate designs and to
contribute to complete of the verification process in a more efficient,
economical, and fast manner.
Testing equivalence of two doses of intravenous iron to treat iron deficiency in pregnancy: A randomised controlled trial
Authors: Froessler Bernd , Schubert Klaus , Palm Peter , Church Richard , Aboustate Natalie , Kelly Thu-Lan , Dekker Gus , Hodyl Nicolette
Published: June 2022

Objective To test equivalence of two doses of intravenous iron (ferric
carboxymaltose) in pregnancy. Design Parallel, two-arm equivalence
randomised controlled trial with an equivalence margin of 5%. Setting
Single centre in Australia. Population 278 pregnant women with iron
deficiency. Methods Participants received either 500 mg (n=152) or
1000mg (n=126) of intravenous ferric carboxymaltose in the second or
third trimester. Main outcome measures The proportion of participants
requiring additional intravenous iron (500mg) to achieve and maintain
ferritin >30ug/L (diagnostic threshold for iron deficiency)
at 4 weeks post-infusion, and at 6 weeks, and 3-, 6- and 12-months
postpartum. Secondary endpoints included repeat infusion rate, iron
status, birth, and safety outcomes. Results The two doses were not
equivalent within a 5% margin at any timepoint. At 4 weeks post
infusion, 26/73 (36%) participants required a repeat infusion in the
500 mg group compared with 5/67 (8%) in the 1000 mg group (difference
in proportions, 0.283 95% confidence interval (0.177, 0.389)). Overall,
participants in the 500 mg arm received twice the repeat infusion rate
(0.81 (SD= 0.824 vs 0.40 (SD= 0.69), rate ratio 2.05, 95% CI (1.45,
2.91)). Conclusions Administration of 1000mg ferric carboxymaltose in
pregnancy maintains iron stores and reduces the need for repeat
infusions. A 500 mg dose requires ongoing monitoring to ensure adequate
iron stores are reached and sustained.
Efficacy of PARPi monotherapy and the impact to subsequent platinum-based chemotherapy in BRCA1/2 mutant ovarian cancer patients with secondary platinum-sensitive relapse
Authors: Song Kun , Ma Yana , Li Ning , Bu Hualei , Huang Yongwen , Jin Chengjuan , Wen Hao , Feng Shuai , Zhang Hui , Kong Beihua , Wu Lingying
Published: June 2022

Objective: The therapeutic effect of PARP inhibitors (PARPi) monotherapy
compared with platinum-based chemotherapy, and the impact to subsequent
platinum-based chemotherapy after PARPi resistance were inconclusive.
Design: Retrospective cohort study. Setting: Patients from seven medical
centers in China. Population: BRCA1/2-mutated ovarian cancer patients
with secondary platinum-sensitive relapse, without any maintenance
regimen after first- and second-line platinum therapy, and the secondary
platinum-free interval (PFI) was more than 6 months. Methods: Patients
in study group (n=31) were treated with PARPi monotherapy until disease
progression, and patients in control group (n=33) were treated with
platinum-based chemotherapy without restriction. Main Outcome Measures:
RECIST and GCIG standard, Kaplan-Meier plotter Results: The objective
response rate (ORR: 77.4% vs. 84.0%, p=0.538) and median
progression-free survival (mPFS: 8.6 vs. 11.1 months, p=0.679) were
comparable. PARPi monotherapy significantly prolonged post-recurrent
survival (PRS, HR=0.35, p=0.024), and was the independent factor
associated with PRS (HR=0.33, p=0.038). The median time from treatment
to first subsequent therapy or death (TFST) of patients with
platinum-based chemotherapy after PARPi progression and patients in
control group with PFI≥6months after third-line platinum-based
chemotherapy was comparable (mTFST: 7.5 vs. 7.1 months, p=0.800).
Further survival analysis showed that PRS of patients with PARPi
monotherapy were similar to patients with PFI≥6 months after third-line
platinum chemotherapy (HR=0.66, p=0.503), and superior to patients with
PFI<6 months after third-line platinum chemotherapy (HR=0.15,
p=0.009). Conclusions: PARPi monotherapy was equivalent to
platinum-based chemotherapy for BRCA1/2-mutated ovarian cancer patients
with secondary platinum-sensitive recurrence, and could improve
prognosis.
Research on Aerial Autonomous Docking and Landing Technology of Dual Multi-rotor UAV
Authors: LIANG WANG , Jiang Xiangqian , Wang Di , Wang Lisheng , Tu Zhijun
Published: June 2022

This study conducted an in-depth investigation of the tracking
controller of an aerial autonomous docking and landing trajectory
system. To examine the system’s overall design, a dual-machine
trajectory-tracking control simulation platform was created via MATLAB
Simulink. Then, an autonomous docking and landing trajectory-tracking
controller based on backpropagation proportional–integral–derivative
control was designed, which fulfilled the trajectory-tracking control
requirements in the autonomous docking and landing process by
efficiently suppressing the external airflow disturbance according to
the simulation results. A YOLOv3-based vision pilot system was designed
to calibrate the rate of the aerial docking and landing position to
eight frame per second. The feasibility of the multi-rotor aerial
autonomous docking and landing system was verified using prototype
flight tests during the day and at night.
Physicochemical and biological properties of calcium phosphate/chondroitin sulfate bone cement containing tetracalcium phosphate nanorod powders
Authors: jahandideh rahim , behnamghader Aliasghar , Hesaraki Saeed
Published: June 2022

Tetracalcium phosphate (TTCP) is one of the main powder components in
self-setting calcium phosphate cements for hard tissue applications. In
this study, two types of calcium phosphate/chondroitin sulfate bone
cements in which TTCP powders in nanoscale-rod like (R-TTCP) and
micro-conventional irregular shape (C-TTCP) were used. The first one was
synthesized by reverse microemulsion chemical process and the second
one, was prepared by thermal conventional method. The results showed
that both cements formed hydroxyapatite as the result of cementation
process. The R-TTCP cement revealed a slightly longer initial but no
difference in final setting time, less compressive strength, higher
porosity and better degradation behavior compared to C-TTCP one. The
both cements presented similar tendency to the formation of a dense
hydroxyapatite on their outer surfaces through immersion in simulated
body fluid. Taking into consideration the initial porosity, the cement
made from R-TTCP rod like nanopowder presented more aptness to
participate in ion exchange in SBF resulting to fill the 15% more
initial porosity via the precipitation of hydroxyapatite mineral. From
the biological point of view, analysis of cytotoxicity and MG63
osteoblastic-cell behavior proved that the both cements had good
viability and proper cell adhesion and activity.
The free will problem: Implications from experimental philosophy, psychology and neuroscience
Authors: Bojanic Marija
Published: June 2022

Throughout history, the phenomenon of free will has mainly been considered from a philosophical perspective, and in the last few decades, it has been investigated in scientific disciplines such as psychology and neuroscience as well. Additionally, some authors suggest that insight into folk intuitions on the problem of free will and determinism would contribute to a better understanding of the phenomenon itself. Lay theories about the free will problem have been empirically examined in experimental philosophy and psychology. The results show that the belief that free will exists is associated with desirable psychological outcomes and that the absence of belief in free will has negative social consequences. Furthermore, the question arises as to how the findings in neuroscience research are presented to society and thus affect free will beliefs. The problem of free will is discussed within experimental philosophy, psychology, and neuroscience.
Emotions and the content of aesthetic experience
Authors: Cvejic Igor
Published: June 2022

In this article, I will draw a parallel between the phenomenology of aesthetic experience and the concept of affective intentionality. One of my aims is to show that ?component? approach is not appropriate both for aesthetic and emotional experience. I will lay emphasis on issues of the shaping of aesthetic content and its non-conceptuality. I will respond to the first problem by introducing the elements of affective intentionality account, particularly by referring to Goldie?s argument concerning the intentionality of feelings. Furthermore, I will clarify that attitude/content distinction cannot stand for aesthetic and emotional experience. The second issue will be addressed by referring to one of interpretations regarding Kant?s account of the judgment of taste. Even if the drawn parallels don?t provide a clear argument for equating aesthetic and emotional experience, the more modest aim of the paper is to point out the lessons of affective intentionality account, which could be helpful in understanding the aesthetic experience.
Evidence on Internal Audit Quality from Transitioning to Remote Audits because of COVID-19
Authors: Eulerich Marc , Wagener Martin , Wood David A.
Published: June 2022

As in-person audits were banned by governments and by company policies due to the COVID-19 pandemic, internal auditors had to transition to remote audits to perform their work. Based on survey responses of internal auditors who have conducted both remote and in-person audits, we find that internal auditors perceive no difference in the efficiency and effectiveness of and stakeholders' reliance on results from remote and in-person audits when considering all responses. However, we also find that perceived efficiency and effectiveness increase the more experience internal auditors have with remote audits. Supplemental analyses show that support from the auditee, but not management or the audit committee, is a central determinant of perceived remote audit success. It is important for internal auditors to consider this later finding in the design of remote audits as it indicates the importance of building support with the auditee to have a successful remote auditing experience.

Data Availability: Please contact the authors.

JEL Classifications: M40; M42; G3; G34.
The Influence of Magnetic Field on the Growth Rate of Rayleigh-Taylor Instability Using Nano-Structured Porous Linings in Inertial Confinement Fusion Fuel Targets
Authors: MALEKPOUR Arash , GHASEMİZAD Abbas
Published: June 2022

Hydrodynamic instabilities, the most significant of which is Rayleigh-Taylor instability (RTI), play a significant role in many physical phenomena. So how to decrease the growth rate of these instabilities is an important purpose in ICF fuel targets. In this research, reducing the growth rate of RTI for various fusion fuel targets has been investigated in two stages: First, it is indicated that applying different nanostructured porous linings at the ablation front of them in the absence of a strong magnetic field causes to decrease RTI growth rate and second, it is shown that using various nanostructured porous linings at the ablation front of these targets accompanying magnetic field exerting to the ablative surface of them, leads to more reduction of RTI growth rate. In both of these two phases, RTI growth rate is acquired analytically using conservation equations, boundary conditions and approximate methods and it is indicated that applying nanostructured porous linings and exerting a powerful magnetic field, will decrease RTI growth rate.
Investigation of The Effect of Geometry Inner Thickness on New Designed Auxetic Structure
Authors: ERDOĞAN İsmail , TOKTAS İhsan
Published: June 2022

Poisson’s ratio is important mechanical property of materials and structure. Material and Structure showing negative Poisson’s ratios are called Auxetic. Properties of the Auxetic structures are very important to design the new structure, especially mechanical properties of the Auxetic materials that have structurally and functionally mission. Many researchers made experimental and theoretical works apropos this matter. In this study, the newly designed Auxetic lattice structure Poisson’s ratio was checked over via exploiting finite element analysis. 14 different lattice structures with respect to inner lattice thickness configurations are investigated. All examined structures have a negative Poisson’s ratio. Inner lattice thickness is increased; negative Poisson’s ratio values are decreased (closes to -1.) in these examined lattice structures. 4x2 lattice orientation has lowest Poisson’s ratio than 4x4 Lattice structure Poisson’s ratio, 4x2 is more Auxetic. 4.9 mm inner lattice thickness and 4x2 lattice matrix examined example has lowest Poisson’s ratio that is -0,55. Beneficial to indicate the purview of the structure on the applied force, the stiffness values and the stiffness/mass values were examined. Their energy dissipation capabilities were analyzed.
A High Programmed Cell Death Protein 1 Hormone Receptor Score on Skin Biopsy is Associated with Sézary Syndrome Diagnosis: A Study of 91 Patients with Erythroderma
Authors: Luherne Camille , Menguy Sarah , Ferte Thomas , Beylot-Barry Marie , Seneschal Julien , Milpied Brigitte , Vial Jean-Philippe , Gros Audrey , Amintas Samuel , Vergier Béatrice , Pham-Ledard Anne
Published: June 2022

Erythroderma is challenging to diagnose. The aim of this single-centre retrospective study was to identify factors that can be used to improve the diagnosis of erythroderma. Among 91 patients with erythroderma, 21 were diagnosed with eczema, 17 with psoriasis, 20 with drug-induced erythroderma, 13 with erythrodermic mycosis fungoides and 20 with Sézary syndrome. Nail alterations, ear involvement, and severe scaling were significantly associated with psoriasis (p = 0.044). Fever and hypereosinophilia were associated with drug-induced erythroderma. Expression of programmed cell death protein 1 was observed in all skin biopsies. However, with Sézary syndrome, programmed cell death protein 1 expression was significantly higher than with other aetiologies. A programmed cell death protein 1 hormone receptor score (H-score) >50 was associated with Sézary syndrome (p < 0.001, sensitivity 75%, specificity 92%) as well as CXCL13 expression (p < 0.044). CD7 loss was more frequent with erythrodermic mycosis fungoides and Sézary syndrome (p = 0.022). This study reports the importance of programmed cell death protein 1 expression for the differential diagnosis of Sézary syndrome and other aetiologies, including erythrodermic mycosis fungoides.
Comparative Study for Designing Two Optical Multilayers Stacks ThF4/AlF3 and ThF4/LiF
Authors: Al-Assadi Zainab Irhayyim , Sultan Murtadha Faaiz
Published: June 2022

The dielectric materials ThF4, AlF3 and LiF and with refract index n=1.5143 n=1.36 and n=1.393 respectively had been used for the optical design Glass/L/H/Air and for two cases Glass/AlF3/ThF4/Air and Glass/LiF/ThF4/Air for 30 layers and for design wavelength λₒ=550 nm and quarterwave thicknesses. The results of this comparative study explain the peak of the gaussian curves. It will increase with increasing the layers but this increase is higher for Glass/AlF3/ThF4/Air and the width of the curves will decrease with increasing the number of layers for the two cases, this will fix the color of the coating and reflect narrow band in the visible region. All results exhibit the coating with AlF3/ThF4 is the best and more efficient for coloration and thermal gain than LiF/ThF4 coating. This study is considered as a modern idea by comparing two multi-layer optical designs and exhibiting which one is better than the other in terms of the solar transmittance (τsol.), solar reflectance (ρsol.), visible reflectance (ρvis.) and coloring efficiency (M), and employ it in the field of building elements for façade solar collectors cladding.
Synthesis and Characterization of some Transition Metals Complexes with new Ligand Azo Imidazole Derivative
Authors: Ward Hussein Ali , Musa Taghreed M. , Nasif Zaizafoon Nabil
Published: June 2022

AZO complexes synthesized by binding metal ions as Mn(II), Co(II), Ni(II) and Cu(II), with the ligand (L) [ethyl 4-((E)-(5-oxo-1-(((1E,2E)-3-phenylallylidene)amino)-2-thioxo-2,5-dihydro-1H-imidazol-4-yl)diazenyl)benzoate] was prepared from three steps ,first step preparation Schiff base product of condensation reaction by reaction Thiosemicarbazide with cinnamaldeyde, second step preparation the Imidazole ring close by reaction ligand 1 with chloroethylacetate, finally preparation Azo ligand(Diazanium compound) by reaction ligand 2 with benzocain. Characterized the ligands and complexes in their solid state using the elemental micro analysis (C.H.N.S), flame atomic absorption. UV-vis spectroscopy, FT-IR, magnetic susceptibility measurements, Mass spectrum, 1H-NMR spectra and electrical molar conductivity. These techniques produced comparable results with those obtained for the solid complexes. From the data of all techniques, octahedral geometry was proposed for Mn(II), Co(II), Ni(II) and Cu(II) complexes.