bluuebunny/crossref_metadata_2025 huggingface dataset:
Volumetric Rendering on Wavelet-Based Adaptive Grid
Authors: Vezolainen Alexei V. , Erlebacher Gordon , Vasilyev Oleg V. , Yuen David A.
Published: July 2022

Numerical modeling of physical phenomena frequently involves processes across a wide range of spatial and temporal scales. In the last two decades, the advancements in wavelet-based numerical methodologies to solve partial differential equations, combined with the unique properties of wavelet analysis to resolve localized structures of the solution on dynamically adaptive computational meshes, make it feasible to perform large-scale numerical simulations of a variety of physical systems on a dynamically adaptive computational mesh that changes both in space and time. Volumetric visualization of the solution is an essential part of scientific computing, yet the existing volumetric visualization techniques do not take full advantage of multi-resolution wavelet analysis and are not fully tailored for visualization of a compressed solution on the wavelet-based adaptive computational mesh. Our objective is to explore the alternatives for the visualization of time-dependent data on space-time varying adaptive mesh using volume rendering while capitalizing on the available sparse data representation. Two alternative formulations are explored. The first one is based on volumetric ray casting of multi-scale datasets in wavelet space. Rather than working with the wavelets at the finest possible resolution, a partial inverse wavelet transform is performed as a preprocessing step to obtain scaling functions on a uniform grid at a user-prescribed resolution. As a result, a solution in physical space is represented by a superposition of scaling functions on a coarse regular grid and wavelets on an adaptive mesh. An efficient and accurate ray casting algorithm is based just on these coarse scaling functions. Additional details are added during the ray tracing by taking an appropriate number of wavelets into account based on support overlap with the interpolation point, wavelet coefficient magnitude, and other characteristics, such as opacity accumulation (front to back ordering) and deviation from frontal viewing direction. The second approach is based on complementing of wavelet-based adaptive mesh to the traditional Adaptive Mesh Refinement (AMR) mesh. Both algorithms are illustrated and compared to the existing volume visualization software for Rayleigh-Benard thermal convection and electron density data sets in terms of rendering time and visual quality for different data compression of both wavelet-based and AMR adaptive meshes.
Microbiological Research on Fermented Dairy Products
Authors: Xiao Luyao , Li Wei
Published: July 2022

Fermented dairy products are widely consumed worldwide due to the nutritional and health benefits [...]
Adsorption of Phthalate Acid Esters by Activated Carbon: The Overlooked Role of the Ethanol Content
Authors: Zhou Yuanhao , Zhao Bingyu , Wang Lingxuan , Li Ting , Ye Hong , Li Shuangyang , Huang Mingquan , Zhang Xianren
Published: July 2022

Ethanol has great effects on the adsorption of phthalate acid esters (PAEs) on activated carbon (AC), which are usually overlooked and hardly studied. This study investigated the overlooked effects of ethanol on the adsorption of PAEs in alcoholic solutions. The adsorption capacities of dibutyl phthalate (DBP) on AC in solutions with ethanol contents of 30, 50, 70, and 100 v% were only 59%, 43%, 19%, and 10% of that (16.39 mg/g) in water, respectively. The ethanol content increase from 50 v% to 100 v% worsened the adsorption performances significantly with the formation of water–ethanol–DBP clusters (decreasing from 13.99 mg/g to 2.34 mg/g). The molecular dynamics simulation showed that the DBP tended to be distributed farther away from the AC when the ethanol content increased from 0 v% to 100 v% (the average distribution distance increased from 5.25 Å to 15.3 Å). The PAEs with shorter chains were more affected by the presence of ethanol than those with longer chains. Taking DBP as an example, the adsorption capacity of AC in ethanol (0.41 mg/g) is only 2.2% of that in water (18.21 mg/g). The application results in actual Baijiu samples showed that the adsorption of PAEs on AC had important effects on the Baijiu flavors.
Fluoride Exposure from Soybean Beverage Consumption: A Toxic Risk Assessment
Authors: Mesa-Infante Virginia , Niebla-Canelo Daniel , Alejandro-Vega Samuel , Gutiérrez Ángel J. , Rubio-Armendáriz Carmen , Hardisson Arturo , Paz Soraya
Published: July 2022

The consumption of vegetable milk as a substitute for cow’s milk has increased in recent years. Of all the vegetable beverages on the market, soy is the most widely consumed. Soy is exposed to contamination by different chemical elements during harvesting. In this study, the concentration of fluoride in soy beverages was analyzed. Fluoride is an element that in high concentrations can be toxic, causing dental and bone fluorosis. The aims of the study were (i) to analyze the fluoride concentration in 30 samples in the most popular brands (A-Brand, B-Brand, C-Brand) of soybean beverages by a fluoride ion selective potentiometer and (ii) to evaluate the toxicological risk derived from its consumption. The fluoride concentrations were 15.5 mg/L (A-Brand), 11.3 mg/L (B-Brand) and 8.5 mg/L (C-Brand). A consumption of 1 to 3 servings/day was established. One serving (200 mL) of soybean beverage offered a contribution percentage over the ADI (acceptable daily intake) for infants and children. Teenagers and adults did not exceed the ADI (10 mg/day). The consumption of soy beverages contributes significantly to the daily intake of fluoride, which could exceed the ADI with a consequent health risk. It is recommended to control the fluoride levels in the raw material and in the final product to assure the safety of these products.
A Comparative Metabolomics Approach for Egyptian Mango Fruits Classification Based on UV and UPLC/MS and in Relation to Its Antioxidant Effect
Authors: Farag Mohamed , Abdelwareth Amr , Zayed Ahmed , Eissa Tarek , Dokalahy Eric , Frolov Andrej , Wessjohann Ludger
Published: July 2022

Mango (Mangifera indica L.) is a tropical climacteric fruit that encompasses a myriad of metabolites mediating for its nutritive value, unique taste, flavor, and medicinal uses. Egypt is among the top mango producers worldwide, albeit little characterization has been made toward its fruits’ chemical composition. This study aims to assess metabolites difference via comparative profiling and fingerprinting of Egyptian mango in context to its cultivar (cv.) type and/or growth province. To achieve such goal, hyphenated chromatographic techniques (UPLC/MS) and UV spectroscopy were employed and coupled to multivariate data analysis for Egyptian mango fruits’ classification for the first time. UPLC/MS led to the detection of a total of 47 peaks identified based on their elution times and MS data, belonging to tannins as gallic acid esters, flavonoids, xanthones, phenolic acids and oxylipids. UV/Vis spectra of mango fruits showed similar absorption patterns mostly attributed to the phenolic metabolites, i.e., gallic acid derivatives and phenolic acids showing λmax at ca. 240 and 270 nm. Modeling of both UPLC/MS and UV data sets revealed that cv. effect predominated over geographical origin in fruits segregation. Awees (AS) cv. showed the richest phenolic content and in agreement for its recognition as a premium cv. of mango in Egypt. Results of total phenolic content (TPC) assay revealed that AS was the richest in TPC at 179.1 mg GAE/g extract, while Langara from Ismailia (LI) showed the strongest antioxidant effect at 0.41 mg TE/g extract. Partial least square modeling of UV fingerprint with antioxidant action annotated gallates as potential contributor to antioxidant effect though without identification of exact moieties based on UPLC/MS. The study is considered the first-time investigation of Egyptian mango to aid unravel phytoconstituents responsible for fruits benefits using a metabolomics approach.
Stability Analysis and Computational Interpretation of an Effective Semi Analytical Scheme for Fractional Order Non-Linear Partial Differential Equations
Authors: Iqbal Javed , Shabbir Khurram , Guran Liliana
Published: July 2022

In this study we will check the stability of the semi analytical technique, the Laplace variational iteration (LVI) scheme, which is the combination of a variational iteration technique and the Laplace transform method. Then, we will apply it to solve some non-linear fractional order partial differential equations. Since the Laplace transform cannot be applied to non-linear problems, the combination of the variational iteration technique with it will give a better and rapidly convergent sequence. Exact solutions may also exist, but we will show that the coupled technique is much better to approximate the exact solutions. The Caputo–Fabrizio fractional derivative will be used throughout the study. In addition, some possible implications of the results given here are connected with fixed point theory.
Food-Grade Bigels with Potential to Replace Saturated and Trans Fats in Cookies
Authors: Quilaqueo Marcela , Iturra Nicole , Contardo Ingrid , Millao Sonia , Morales Eduardo , Rubilar Mónica
Published: July 2022

Fats play multiple roles in determining the desirable characteristics of foods. However, there are health concerns about saturated and trans fats. Bigels have been proposed as a novel fat replacer in foods. This research evaluated the role of the type of hydrogel in the development of bigels to be used as fat replacers in cookies. Bigels were made with beeswax/canola oil oleogel and sodium alginate and carboxymethylcellulose hydrogels. The results showed that the peroxide value and binding capacity of bigels were affected by the type of hydrogel used. However, their fatty acid profile, p-anisidine value, oxidative stability, and texture remained unchanged. Using bigels as fat replacers, cookies were obtained with a hardness similar to those with original shortening, showing the potential of bigels for use in foods.
Changes in the Regime of Erosive Precipitation on the European Part of Russia for the Period 1966–2020
Authors: Chizhikova Nelli , Yermolaev Oleg , Golosov Valentin , Mukharamova Svetlana , Saveliev Anatoly
Published: July 2022

The objective of this work is to analyze the spatial-temporal features of the trends in the frequency and amount of erosion-hazardous precipitation in the European part of Russia (EPR) for the period 1966–2020, as a reflection of the influence of climatic changes on surface runoff from the cultivated slopes during the warm season. One hundred and fifty-nine EPR weather stations were selected for analysis based on the length of the time series and the amount of missing data. Several characteristics of erosion-hazardous precipitation were considered: the number of days with a daily precipitation of more than 12.7 mm, the number of days with a daily precipitation of 12.7 to 40 mm, the number of days with a daily precipitation of more than 40 mm, the maximum one-day precipitation. In general, it can be stated that even within the southern taiga, mixed forests, and forest-steppe ecoregion (broad-leaved forests), within which a positive increase in the frequency of erosion-hazardous precipitation was detected, there was no significant increase in the rate of washout and linear washout, which is primarily due to a more significant reduction of slope runoff and soil washout during spring snowmelt. Precipitation, the daily amount of which is more than 40 mm, as well as the maximum daily amount of precipitation, show an upward trend in the western contact zone of mixed forests and forest-steppe, on the Black Sea coast, as well as in the northern foothills of the Caucasus, where their contribution to erosion processes is likely to increase against the decrease in the number of days with precipitation of a 12.7–40 mm daily amount.
Archaeobotanical Study of Tell Khamîs (Syria)
Authors: Valera Javier , Matilla-Seiquer Gonzalo , Obón Concepción , Rivera Diego
Published: July 2022

Tell Khamîs, an archaeological site of the Syrian region of Upper Jazeera, is 3 km east of the Euphrates and 31 km from Yarâblûs (ancient Karkemiš); archaeological excavations determined seven different levels (Early Bronze, Middle Bronze, Aramaic, Assyrian, Persian, Hellenistic, and Islamic). This study aims to identify plant remains recovered during the excavation of the site and to place them within the chronology of Tell Khamîs and in the context of the archaeobotanical evidence for the Upper Euphrates. A total of 88 sediment samples were collected, and seeds, recovered via flotation, were identified using optical and SEM microscopy. A total of 20,606 whole remains and 37,646 fragments belonging to 92 taxa and 35 plant families were identified. Seed lists were compared with those from other sites, and the results were analyzed using multivariate techniques. Barley is particularly noteworthy for the number of remains; this species was found in 49 different samples, notably, in a silo of about 4 m3 in volume. Middle Bronze Age and Assyrian levels are the richest in remains; the site presents a maximum of documented activity in the Middle Bronze Age period, and the most interesting taxa from a paleoenvironmental and cultural point of view are represented by one or a few seeds.
Characterizing the Spatial Uniformity of Light Intensity and Spectrum for Indoor Crop Production
Authors: Balázs László , Dombi Zoltán , Csambalik László , Sipos László
Published: July 2022

Maintaining uniform photon irradiance distribution above the plant canopy is a fundamental goal in controlled environment agriculture (CEA). Spatial variation in photon irradiance below the light saturation point will drive differences in individual plant development, decreasing the economic value of the crop. Plant growth is also affected by the spectral composition of light. So far, little attention has been paid to the quantification of the spatial variability in horticultural lighting applications. This work provides a methodology to benchmark and compare lighting installations used in indoor cultivation facilities. We measured the photon irradiance distributions underneath two typical grow light installations using a 10 × 10 measurement grid with 100 mm spacing. We calculated photon irradiance values for each grid point for 100 nm-wide blue, green, red and far-red wavebands covering the 400–800 nm range. We showed that the generally used uniformity metric defined as the minimum to average ratio of PPFD is not appropriate for the characterization of light uniformity in horticultural lighting applications. Instead, we propose to normalize photon irradiance to the maximum, analyze the histograms constructed from relative photon irradiance values and consider the light response of the cultivated crop while comparing the performance of CEA grow systems.
Elicitor Activity of Curdlan and Its Potential Application in Protection of Hass Avocado Plants against Phytophthora cinnamomi Rands
Authors: Guarnizo Nathalie , Álvarez Andree , Oliveros Diego , Barbosa Oveimar , Joli Jordi Eras , Bermúdez-Cardona María Bianney , Murillo-Arango Walter
Published: July 2022

Phytophthora cinnamomi causes one of the most important diseases in avocado crop and its chemical management represents 25% of the production cost per year. Induction of plant defense responses by elicitors is a promising strategy that is compatible with sustainable agriculture. This study aimed to evaluate the effect of curdlan application on the induction of defense responses in avocado plants against P. cinnamomi. The trials were conducted under greenhouse conditions, and curdlan leaf spraying was performed one day before the inoculation of the pathogen. The results showed that the application of elicitor significantly increased the protection of avocado plants against P. cinnamomi, decreasing the injury and wilting. The Curd + Phy treatment improved the defenses of plants by increasing the enzymes peroxidase (POD) and polyphenol oxidase (PPO) in the first 3 h after inoculation and increasing the enzymes superoxide dismutase (SOD) and phenylalanine ammonium lyase (PAL) 144 h after inoculation (p < 0.05). Also, chlorophyll and carotenoid content increased or remained stable in Curd + Phy treatment. Therefore, these results suggest that curdlan increases the protection against P. cinnamomi and its protection could be due to an increase in the activity of the enzymes related to the phenylpropanoid pathway as well as the effect on chlorophyll and carotenoids.
Dwarfing Rootstock ‘Yunnan’ Quince Promoted Fruit Sugar Accumulation by Influencing Assimilate Flow and PbSWEET6 in Pear Scion
Authors: Wang Xiaoli , Cong Liu , Pang Jianwen , Chen Yu , Wang Zhigang , Zhai Rui , Yang Chengquan , Xu Lingfei
Published: July 2022

‘Yunnan’ quince (Cydonia oblonga Mill.) is used as the dwarfing rootstock for pear (Pyrus spp.). Here, we reported that the sugar contents in mature ‘Zaosu’ pear fruit grafted on ‘Yunan’ quince (Z/Q) were higher than that in ‘Zaosu’ pear fruit grafted on ‘Duli’ (Pyrus betulifolia) (Z/D). To investigate the underlying mechanism, the leaf photosynthetic capacity and the leaf-to-fruit assimilate transport capacity were initially analyzed. The leaf photosynthetic capacity was similar between Z/Q and Z/D, but the assimilate transport capacity was greater for Z/Q than for Z/D. Sugar transporters mediate the distribution of assimilates; therefore, changes in PbSWEET transcriptional patterns were examined. PbSWEET6 was highly expressed in Z/Q fruit. Thus, the PbSWEET6 function related to assimilate transport was further verified. Sucrose and glucose contents increased in transgenic tomato fruit and pear fruit calli overexpressing PbSWEET6. Taken together, these results suggest that ‘Yunnan’ quince positively regulated fruit sugar contents by influencing the flow of PbSWEET6-involved assimilates in the scion.
Stochastic Analysis of the Marginal and Dependence Structure of Streamflows: From Fine-Scale Records to Multi-Centennial Paleoclimatic Reconstructions
Authors: Pizarro Alonso , Dimitriadis Panayiotis , Iliopoulou Theano , Manfreda Salvatore , Koutsoyiannis Demetris
Published: July 2022

The identification of the second-order dependence structure of streamflow has been one of the oldest challenges in hydrological sciences, dating back to the pioneering work of H.E Hurst on the Nile River. Since then, several large-scale studies have investigated the temporal structure of streamflow spanning from the hourly to the climatic scale, covering multiple orders of magni-tude. In this study, we expanded this range to almost eight orders of magnitude by analysing small-scale streamflow time series (in the order of minutes) from ground stations and large-scale streamflow time series (in the order of hundreds of years) acquired from paleocli-matic reconstructions. We aimed to determine the fractal behaviour and the long-range de-pendence behaviour of the streamflow. Additionally, we assessed the behaviour of the first four marginal moments of each time series to test whether they follow similar behaviours as sug-gested in other studies in the literature. The results provide evidence in identifying a common stochastic structure for the streamflow process, based on the Pareto–Burr–Feller marginal dis-tribution and a generalized Hurst–Kolmogorov (HK) dependence structure.
The Progress and Future of US Newborn Screening
Authors: Watson Michael S. , Lloyd-Puryear Michele A. , Howell R. Rodney
Published: July 2022

Progress in newborn screening (NBS) has been driven for 60 years by developments in science and technology, growing consumer advocacy, the actions of providers involved in the care of rare disease patients, and by federal and State government funding and policies. With the current explosion of clinical trials of treatments for rare diseases, the pressure for expansion has grown, and concerns about the capacity for improvement and growth are being expressed. Genome and exome sequencing (GS/ES) have now opened more opportunities for early identification and disease prevention at all points in the lifespan. The greatest challenge facing NBS stems from the conditions most amenable to screening, and new treatment development is that we are screening for rare genetic diseases. In addition, understanding the spectrum of severity requires vast amounts of population and genomic data. We propose recommendations on improving the NBS system and addressing specific demands to grow its capacity by: better defining the criteria by which screening targets are established; financing the NBS system’s responsiveness to opportunities for expansion, including engagement and funding from stakeholders; creating a national quality assurance, data, IT, and communications infrastructure; and improving intra-governmental communications. While our recommendations may be specific to the United States, the underlying issues should be considered when working to improve NBS programs globally.
A Multi-Sensory Guidance System for the Visually Impaired Using YOLO and ORB-SLAM
Authors: Xie Zaipeng , Li Zhaobin , Zhang Yida , Zhang Jianan , Liu Fangming , Chen Wei
Published: July 2022

Guidance systems for visually impaired persons have become a popular topic in recent years. Existing guidance systems on the market typically utilize auxiliary tools and methods such as GPS, UWB, or a simple white cane that exploits the user’s single tactile or auditory sense. These guidance methodologies can be inadequate in a complex indoor environment. This paper proposes a multi-sensory guidance system for the visually impaired that can provide tactile and auditory advice using ORB-SLAM and YOLO techniques. Based on an RGB-D camera, the local obstacle avoidance system is realized at the tactile level through point cloud filtering that can inform the user via a vibrating motor. Our proposed method can generate a dense navigation map to implement global obstacle avoidance and path planning for the user through the coordinate transformation. Real-time target detection and a voice-prompt system based on YOLO are also incorporated at the auditory level. We implemented the proposed system as a smart cane. Experiments are performed using four different test scenarios. Experimental results demonstrate that the impediments in the walking path can be reliably located and classified in real-time. Our proposed system can function as a capable auxiliary to help visually impaired people navigate securely by integrating YOLO with ORB-SLAM.
Sustainable Mobility as a Service: Framework and Transport System Models
Authors: Vitetta Antonino
Published: July 2022

Passenger mobility plays an important role in today’s society and optimized transport services are a priority. In recent years, MaaS (Mobility as a Service) has been studied and tested as new integrated services for users. In this paper, MaaS is studied considering the sustainability objectives and goals to be achieved with particular reference to the consolidated methodologies adopted in the transport systems engineering for design, management, and monitoring of transport services; it is defined as Sustainable MaaS (S-MaaS). This paper considers the technological and communication platform essential and assumed to be a given considering that it has been proposed in many papers and it has been tested in some areas together with MaaS. Starting from the MaaS platform, the additional components and models necessary for the implementation of an S-MaaS are analyses in relation to: a Decision Support System (DSS) that supports MaaS public administrations and MaaS companies for the design of the service and demand management; a system for the evaluation of intervention policies; and also considers smart planning for a priori and a posteriori evaluation of sustainability objectives and targets.
More Constructions of Light MDS Transforms Based on Known MDS Circulant Matrices
Authors: Wang Jin-Bo , Wu You , Zhou Yu
Published: July 2022

Maximum distance separable (MDS) codes have the maximum branch number in cryptography, and they are generally used in diffusion layers of symmetric ciphers. The diffusion layer of the Advanced Encryption Standard (AES) uses the circulant MDS matrix with the row element of {2;3;1;1} in F28. It is the simplest MDS matrix in  F2n4, recorded as A=Circ(2;3;1;1). In this paper, we study the more extensive MDS constructions of A in F2n4. By transforming the element multiplication operation in the finite field into the bit-level operation, we propose a multivariable operation definition based on simple operations, such as cyclic shift, shift, and XOR. We apply this multivariable operation to more lightweight MDS constructions of A and discuss the classification of the MDS clusters. We also give an example of the MDS cluster of A. Without changing the structure, elements, and the implementation cost of the known MDS matrix, the number of existing MDS transformations is expanded to n2/2 times that of its original. The constructions in this paper provide rich component materials for the design of lightweight cryptographic algorithms.
Comparison of Alternative Application Methods for Anti-Varroa Lithium Chloride Treatments
Authors: Kolics Balázs , Kolics Éva , Mátyás Kinga , Taller János , Specziár András
Published: July 2022

Varroosis is one of the most dangerous threats to the bee industry but means of its treatment are still unsatisfactory. Lithium-based anti-Varroa treatments may provide an alternative, as this trace element can be a natural component of honey and is well tolerated by adult bees. However, it can be toxic to larvae and its use in beekeeping practice is not yet well understood. The present study aimed to investigate the efficacy of relevant application methods of acaricides used in beekeeping practice in brood-free conditions for lithium. Vaporisation proved to be an inefficient method of lithium treatment and killed only 9.9 ± 3.3% (mean ± SD) of mites in the hive. Lithium-impregnated paper strips showed moderate efficiency by killing 55.1 ± 26.2% of mites. The most effective way of applying lithium was the trickling method; different trickling treatments decreased the abundance of mites on average by 65 to 99.7%, depending on the applied dosage and the number of treatments. Repeated trickling treatments were more effective than single treatments, and they generally provided >90% efficiency. Experiments also proved that adding sugar to the trickling solution does not influence treatment efficiency. Thus, it is suggested that repeated and sugar-free trickling treatments with moderate lithium dosage could be the most rational methodology. Since lithium is not yet legalised in beekeeping practice, comprehensive studies are also needed to uncover the amount of lithium residue in bee products, depending on the treatment parameters.
Fluctuating Asymmetry in the Polymorphic Sand Cricket (Gryllus firmus): Are More Functionally Important Structures Always More Symmetric?
Authors: Whalen Matthew R. , Chang Krista J. , Jones Alexandria B. , Rivera Gabriel , Worthington Amy M.
Published: July 2022

Fluctuating asymmetry (FA) may serve as a reliable indicator of the functional importance of structures within an organism. Primary locomotor structures often display lower levels of FA than other paired structures, highlighting that selection can maintain symmetry in fitness-enhancing traits. Polyphenic species represent an attractive model for studying the fine-scale relationship between trait form and function, because multiple morphs exhibit unique life history adaptations that rely on different traits to maximize fitness. Here, we investigated whether individuals of the wing polyphenic sand field cricket (Gryllus firmus) maintain higher levels of symmetry in the bilateral structures most vital for maximizing fitness based on their specific life history strategy. We quantified FA and directional asymmetry (DA) across a suite of key morphological structures indicative of investment in somatic growth, reproduction, and flight capability for males and females across the flight-capable longwing (LW) and flight-incapable shortwing (SW) morphs. Although we did not find significant differences in FA across traits, hindwings lacked DA that was found in all other structures. We predicted that functionally important traits should maintain a higher level of symmetry; however, locomotor compensation strategies may reduce the selective pressures on symmetry or developmental constraints may limit the optimization between trait form and function.
Vast Gene Flow among the Spanish Populations of the Pest Bactrocera oleae (Diptera, Tephritidae), Phylogeography of a Metapopulation to Be Controlled and Its Mediterranean Genetic Context
Authors: Lantero Esther , Matallanas Beatriz , Ochando M. Dolores , Callejas Carmen
Published: July 2022

Spain is the leading producer of olives and olive oil. Ninety-five percent of world production originate from Spain and other regions of the Mediterranean Basin. However, these olive-growing countries face a major problem, the harmful fly Bactrocera oleae, the main pest of olive crops. To improve its control, one of the challenges is the further knowledge of the species and populations dynamics in this area. A phylogeographic work is necessary to further characterise the levels and distribution patterns of genetic diversity of the Spanish populations and their genetic relationships with other Mediterranean populations. A 1151 bp fragment of the mitochondrial cytochrome oxidase subunit I (COI) gene has been analysed in over 250 specimens of the six main Mediterranean countries via sequencing. Genetic diversity parameters were high; 51 new haplotypes have been identified showing a geographical pattern across the Mediterranean area. The data revealed that olive fruit fly populations have been long time established in the Mediterranean Basin with two genetic groups. Gene flow seems to be the main process in shaping this genetic structure as well as fly’s colonisation routes that have paralleled those of the olive tree.
Influence of the COVID-19 Pandemic on Quality of Life, Mental Health, and Level of Physical Activity in Colombian University Workers: A Longitudinal Study
Authors: García-Garro Patricia Alexandra , Aibar-Almazán Agustín , Rivas-Campo Yulieth , Vega-Ávila Gloria Cecilia , Afanador-Restrepo Diego Fernando , Hita-Contreras Fidel
Published: July 2022

The COVID-19 pandemic has had a strong influence on people’s quality of life, and the different restrictive measures during the phases of the pandemic have had consequences for physical and mental health. This study determined the changes in health-related quality of life (HRQoL), sleep quality, depression symptoms (DS), and physical activity (PA) level of middle-aged Colombian university personnel during the COVID-19 pandemic. The analysis was performed following a longitudinal design on a sample of 354 people at four points before and during the pandemic. The International Physical Activity Questionnaire (IPAQ), the SF-12v2, the Pittsburgh Sleep Quality Index (PSQI), and the Zung Self-Rating Depression Scale (ZSDS) were included in an online survey. The measurements showed a decrease in quality of life with respect to PCS from 91.66 ± 10.78 to 83.64 ± 17.22 (p = 0.000) and MCS from 87.57 ± 12.23 to 80.90 ± 17.31, while poor sleep quality increased from 25.99% to 47.46% (p = 0.000), with DS reaching the peak during mandatory confinement (14.69%). Regarding the level of physical activity, the period of mandatory confinement inverted the proportion, highlighting active people as a minority (32.2%). In the multivariate analysis, we adjusted for age, sex, BMI, and socioeconomic level, discarding confounding effects and their interactions with the results obtained. In conclusion, this study showed that the pandemic has had a negative impact on sleep quality, HRQoL, DS, and PA level.
Frontal Fibrosing Alopecia: A Histopathological Comparison of the Frontal Hairline with Normal-Appearing Scalp
Authors: Porriño-Bustamante María Librada , Pinedo-Moraleda Fernando Javier , Fernández-Flores Ángel , Montero-Vílchez Trinidad , Fernández-Pugnaire María Antonia , Arias-Santiago Salvador
Published: July 2022

Frontal fibrosing alopecia is characterized by the presence of a lymphocytic inflammatory infiltrate around the upper follicle and by perifollicular fibrosis, which results in the destruction of the hair follicle. Recent reports have also found the presence of those findings in clinically unaffected areas. The aim of this report is to perform a deeper analysis of the histopathological features of this apparently unaffected scalp. A cross-sectional study including 52 women with frontal fibrosing alopecia was performed. Two areas were biopsied: the frontal hairline and a normal-appearing scalp area. Sebaceous glands were reduced/absent in 80.8% of the frontal hairline samples compared to 42.3% of the “healthy scalp” samples (p = 0.001). Inflammatory infiltrate was observed in 92.3% of patients in the frontal hairline and in 86.5% of them in the “healthy scalp” area (p = 0.508), although the severity was higher in the former (p = 0.013). Follicular epithelium changes were seen in 70.6% of the frontal hairline biopsies compared to 48.1% of the “healthy scalp” biopsies (p = 0.012). Fibrous tissular changes were noted in 80.8% and 53.8% of the frontal hairline and “healthy scalp” biopsies, respectively (p = 0.003). In conclusion, the histopathological features of frontal fibrosing alopecia are shared by both affected and clinically unaffected areas.
Influenza Myopericarditis and Pericarditis: A Literature Review
Authors: Radovanovic Milan , Petrovic Marija , Barsoum Michel K. , Nordstrom Charles W. , Calvin Andrew D. , Dumic Igor , Jevtic Dorde , Hanna Richard D.
Published: July 2022

Myopericarditis is a rare complication of influenza infection. The presentation may range from mild and frequently unrecognized, to fulminant and potentially complicated by cardiogenic and/or obstructive shock (tamponade), which is associated with high mortality. We performed a review of literature on all influenza pericarditis and myopericarditis cases according to PRISMA guidelines using the PubMed search engine of the Medline database. Seventy-five cases of influenza myopericarditis and isolated pericarditis were identified from 1951 to 2021. Influenza A was reported twice as often as influenza B; however, influenza type did not correlate with outcome. Men and elderly patients were more likely to have isolated pericarditis, while women and younger patients were more likely to have myopericarditis. All included patients had pericardial effusion, while 36% had tamponade. Tamponade was more common in those with isolated pericarditis (41.2%) than myopericarditis (13.8%). Cardiogenic shock was more common in patients with myopericarditis (64%), with an overall mortality rate of 14.7%. Nearly 88% of the recovered patients remained without long-term complications reported. Conclusion: Influenza A appears a more common cause of pericarditis and myopericarditis. Isolated pericarditis was more commonly associated with tamponade but without reported deaths, whereas myopericarditis was more commonly associated with cardiogenic shock and death (19%).
Effect of Scanned Area and Operator on the Accuracy of Dentate Arch Scans with a Single Implant
Authors: Marques Vinicius Rizzo , Çakmak Gülce , Yilmaz Hakan , Abou-Ayash Samir , Donmez Mustafa Borga , Yilmaz Burak
Published: July 2022

Studies have shown the effect of the operator and scanned areas on the accuracy of single implant scans. However, the knowledge on the scan accuracy of the remaining dental arch during single implant scans, which may affect the occlusion, is limited. The aim of this study was to investigate the effect of scanned areas and the operator on the scan accuracy of a dentate arch while scanning a single implant. A dentate model with an anterior implant was digitized with a laboratory scanner (reference scan). Three operators with similar experience performed 10 complete- and 10 partial-arch scans (left 2nd molar to right canine) with an intraoral scanner (TRIOS 3), and these scans were superimposed over the reference. The accuracy was analyzed at 22 points in complete-arch and at 16 points in partial-arch scans on 2nd molars and incisors. Data were evaluated with 2-way ANOVA and Tukey HSD tests (α = 0.05). The trueness of the total scanned area was higher in partial- than in complete-arch scans (p < 0.001). The trueness and precision of the scans were higher in the anterior site compared with the posterior in complete- (trueness: p ≤ 0.022, precision: p ≤ 0.003) and partial-arch (trueness: p ≤ 0.016, precision: p ≤ 0.016) scans of each operator and when the operator scan data were pooled. The complete-arch scan’s precision was not influenced by the operator (p ≥ 0.029), whereas the partial-arch scans of operator 1 and 2 were significantly different (p = 0.036). Trueness was higher in partial- compared with complete-arch scans, but their precision was similar. Accuracy was higher in the anterior site regardless of the scan being a partial- or a complete-arch. The operator’s effect on the accuracy of partial- and complete-arch scans was small.
Approach to Patients with Obesity and Other Cardiovascular Risk Factors in Primary Care Using the Delphi Methodology
Authors: Morillas Blasco Pedro , Gómez Moreno Silvia , Febles Palenzuela Tomás , Pallarés Carratalá Vicente
Published: July 2022

Background: Implementing preventive strategies for patients with obesity would improve the future burden of cardiovascular diseases. The objective was to present the opinions of experts on the approach to treating patients with obesity and other cardiovascular risk factors from a primary care perspective in Spain; Methods: Using the Delphi technique, a 42-question questionnaire was developed based on results from the scientific literature, and sent to 42 experts in primary care. Two rounds of participation were held; Results: There is a close relationship between obesity and cardiovascular risk factors among primary care physicians. It is necessary to use a checklist in primary care that includes metabolic parameters such as body mass index, waist circumference, and levels of C-reactive protein and ferritin. It is also useful to combine pharmacological treatment, such as liraglutide, with a change in lifestyle to achieve therapeutic goals in this population; Conclusions: There is a high level of awareness among experts in Spain regarding obesity and other cardiovascular risk factors, and the need to address this pathology comprehensively. The need to incorporate specific tools in primary care consultations that allow for better assessment and follow-up of these patients, such as cuffs adapted to arm size or imaging techniques to assess body fat, is evident. Teleconsultation is imposed as a helpful tool for follow-up. Experts recommend that patients with obesity and associated comorbidities modify their lifestyle, incorporate a Mediterranean diet, and administer liraglutide.
Prognostic Factors and Optimal Surgical Management for Lumbar Spinal Canal Stenosis in Patients with Diffuse Idiopathic Skeletal Hyperostosis
Authors: Nakajima Hideaki , Honjoh Kazuya , Watanabe Shuji , Matsumine Akihiko
Published: July 2022

Lumbar spinal canal stenosis (LSS) and diffuse idiopathic skeletal hyperostosis (DISH) tend to develop in the elderly, resulting in an increased need for lumbar surgery. However, DISH may be a risk factor for poor clinical outcomes following lumbar decompression surgery, especially in patients with DISH extending to the lumbar segment (L-DISH). This study aimed to identify the prognostic factors of LSS with L-DISH and propose an optimal surgical management approach to improve clinical outcomes. Of 934 patients who underwent lumbar decompression surgery, 145 patients (15.5%) had L-DISH. In multivariate linear regression analysis of the JOA score improvement rate, the presence of vacuum phenomenon at affected segments (estimate: −15.14) and distance between the caudal end of L-DISH and decompressed/fused segments (estimate: 7.05) were independent prognostic factors. In logistic regression analysis of the surgical procedure with JOA improvement rate > 25% in L-DISH patients with both negative prognostic factors, the odds ratios of split laminotomy and short-segment fusion were 0.64 and 0.21, respectively, with conventional laminotomy as the reference. Therefore, to achieve better clinical outcomes in cases with decompression at the caudal end of L-DISH, decompression surgery without fusion sparing the osteoligamentous structures at midline should be considered as the standard surgery.
Bone Metabolism Alteration in Patients with Inflammatory Bowel Disease
Authors: Tulewicz-Marti Edyta Maria , Lewandowski Konrad , Rydzewska Grażyna
Published: July 2022

Background: Metabolic bone disease is a common disorder, but there is a lack of data on it in patients with inflammatory bowel disease (IBD). Methods: In this prospective, one-centre study, we assessed bone mineral and vitamin D alterations in 187 IBD patients (119 with Crohn’s disease (CD) and 68 with ulcerative colitis (UC)). Results: While 81.3% of the patients had vitamin D deficiency, 14.2% of them had a severe deficiency. Elevated serum PTH concentrations were found in 14.9% of the patients. Only in 4.1% of cases was there an elevated level of a serum marker for bone formation (osteocalcin), whereas in 14.4% of cases, the bone resorption marker (CTX) was raised. The concentration of phosphate in urine was higher in the CD than in the UC group (51.20 vs. 31.25; p = 0.003). PTH was negatively associated with vitamin D level. Among the patients receiving corticosteroids, the CTX and CRP median levels were higher (0.49 vs. 0.38; p = 0.013 and 6.45 vs. 2.2; p = 0.029, respectively) compared with the group who did not receive them. Urine phosphate levels were lower (48.60 vs. 26.00; p = 0.005), as were osteocalcin (15.50 vs. 23.80; p < 0.001), and PTH (29.05 vs. 36.05; p = 0.018). Conclusions: Bone mineral alterations were common in patients with IBD, mostly in the CD patients. This may be associated with poor absorption, making CD patients vulnerable to changes in bone mineralization. Vitamin D supplementation remains crucial, especially when taking corticosteroids.
Development and Validation of a Virtual Reality Simulator for Robot-Assisted Minimally Invasive Liver Surgery Training
Authors: Lefor Alan Kawarai , Heredia Pérez Saúl Alexis , Shimizu Atsushi , Lin Hung-Ching , Witowski Jan , Mitsuishi Mamoru
Published: July 2022

The value of kinematic data for skill assessment is being investigated. This is the first virtual reality simulator developed for liver surgery. This simulator was coded in C++ using PhysX and FleX with a novel cutting algorithm and used a patient data-derived model and two instruments functioning as ultrasonic shears. The simulator was evaluated by nine expert surgeons and nine surgical novices. Each participant performed a simulated metastasectomy after training. Kinematic data were collected for the instrument position. Each participant completed a survey. The expert participants had a mean age of 47 years and 9/9 were certified in surgery. Novices had a mean age of 30 years and 0/9 were certified surgeons. The mean path length (novice 0.76 ± 0.20 m vs. expert 0.46 ± 0.16 m, p = 0.008), movements (138 ± 45 vs. 84 ± 32, p = 0.043) and time (174 ± 44 s vs. 102 ± 42 s, p = 0.004) were significantly different for the two participant groups. There were no significant differences in activating the instrument (107 ± 25 vs. 109 ± 53). Participants considered the simulator realistic (6.5/7) (face validity), appropriate for education (5/7) (content validity) with an effective interface (6/7), consistent motion (5/7) and realistic soft tissue behavior (5/7). This study showed that the simulator differentiates between experts and novices. Simulation may be an effective way to obtain kinematic data.
Comparison of the Effect on Vessel Density and RNFL between Carteolol and Latanoprost
Authors: Nutterova Elena , Fus Martin , Bartosova Libuse , Klimesova Iva , Lestak Jan
Published: July 2022

The aim of the study was to compare the treatment of hypertensive glaucoma (HTG) in the early stages with carteolol and latanoprost by assessing the change in vessel density (VD) and retinal nerve fibre layer (RNFL). Methods: The first group with diagnosed HTG consisted of 46 eyes treated with carteolol; the second group consisted of 52 eyes treated with latanoprost. The following examinations were evaluated in all patients: intraocular pressure (IOP), retinal nerve fibre layer (RNFL), vessel density (VD) and visual field examination (glaucoma fast threshold test). The results were compared before treatment and 3 months after treatment. Results: There was no difference in the overall visual field defect (OD) between groups before treatment. After treatment, there was a decrease in IOP in both groups (carteolol-treated group had a mean decrease of 5.8 mmHg and latanoprost-treated eyes had a mean decrease of 7 mmHg). This difference was not statistically significant (p = 0.133). No similar difference was observed for RNFL (p = 0.161). In contrast, the change in the VD parameter was statistically significant between groups (p < 0.05), with a greater difference observed in the carteolol-treated group of eyes. Carteolol had a better effect on the VD.
Prostate Cancer Brain Metastasis: Review of a Rare Complication with Limited Treatment Options and Poor Prognosis
Authors: Rajeswaran Kobisha , Muzio Kaitlin , Briones Juan , Lim-Fat Mary Jane , Tseng Chia-Lin , Smoragiewicz Martin , Detsky Jay , Emmenegger Urban
Published: July 2022

Brain metastases (BM) are perceived as a rare complication of prostate cancer associated with poor outcome. Due to limited published data, we conducted a literature review regarding incidence, clinical characteristics, treatment options, and outcomes of patients with prostate cancer BM. A literature analysis of the PubMed, MEDLINE, and EMBASE databases was performed for full-text published articles on patients diagnosed with BM from prostate cancer. Eligible studies included four or more patients. Twenty-seven publications were selected and analyzed. The sources of published patient cohorts were retrospective chart reviews, administrative healthcare databases, autopsy records, and case series. BM are rare, with an incidence of 1.14% across publications that mainly focus on intraparenchymal metastases. Synchronous visceral metastasis and rare histological prostate cancer subtypes are associated with an increased rate of BM. Many patients do not receive brain metastasis-directed local therapy and the median survival after BM diagnosis is poor, notably in patients with multiple BM, dural-based metastases, or leptomeningeal dissemination. Overall, prostate cancer BM are rare and associated with poor prognosis. Future research is needed to study the impact of novel prostate cancer therapeutics on BM incidence, to identify patients at risk of BM, and to characterize molecular treatment targets.