bluuebunny/crossref_metadata_2025 huggingface dataset:
Adult-Onset Genetic Leukoencephalopathies With Movement Disorders
Authors: Fu Mu-Hui , Chang Yung-Yee
Published: March 2023

Genetic leukoencephalopathies (GLEs) are a group of white matter abnormalities with heterogeneous radiological and phenotypic features. Although these conditions have mostly been described in children, adult-onset cases are increasingly recognized owing to the widespread use of neuroimaging and advances in molecular genetic testing. The disease course is often progressive with a varied spectrum of presentations, trapping neurologists in the dilemma of differential diagnosis. Movement disorders are among the most common symptoms, and their diversity makes diagnosis challenging. In this review, we focus on adult-onset GLEs with movement disorders and offer a step-by-step diagnostic approach by clarifying the phenomenology of movement, advising investigations for acquired causes, describing the clinical and radiological clues to each disease, emphasizing the limitations of advanced molecular testing, and discussing the future application of artificial intelligence. We provide a list summarizing the leukoencephalopathies associated with different categories of movement disorders. In addition to guiding clinicians on how to narrow the list of differential diagnoses with the tools currently available, another aim of this review is to emphasize the inevitable trend toward applying advanced technology in diagnosing these difficult diseases.
Molecular dynamics simulations of water-ethanol droplet on silicon surface
Authors: Biswas Rima
Published: March 2023

Molecular dynamics simulations are used to explore the wetting behavior of a water-ethanol droplet on the silicon surface. The effect of ethanol concentration on the wettability of a water-ethanol droplet on the silicon surface was analysed by calculation of contact angle. At 30% ethanol concentrations, the water contact angle was 50.7°, while at 50% ethanol concentrations, it was 36°. The results showed that the contact angle of a droplet on a silicon surface decreases with increasing ethanol concentrations. The formation of hydrogen bonds (HBs) between water-water molecules was 677 for the 30% ethanol system, while at 50% ethanol concentrations, it was 141. The number of hydrogen bonds between water molecules reduces as the ethanol concentrations rise. The HBs between water molecules and the silicon surface is seen to grow as the ethanol concentration rises. The overall potential energies of pure water, 7:3 water-ethanol, and 1:1 water-ethanol systems are −74.4, −96.16, and −158.59 kcal/mol, respectively. The contact angle and number density of water molecules on the surface of the silicon revealed that at different ethanol concentrations, more water molecules are distributed on the silicon surface.
Exploring relationships between physician stress, burnout, and diagnostic elements in clinician notes
Authors: Sullivan Erin E. , Khazen Maram , Arabadjis Sophia D. , Mirica Maria , Ramos Jason M. , Olson Andrew P.J. , Linzer Mark , Schiff Gordon D.
Published: March 2023

Objectives

To understand the relationship between stressful work environments and patient care by assessing work conditions, burnout, and elements of the diagnostic process.

Methods

Notes and transcripts of audiotaped encounters were assessed for verbal and written documentation related to psychosocial data, differential diagnosis, acknowledgement of uncertainty, and other diagnosis-relevant contextual elements using 5-point Likert scales in seven primary care physicians (PCPs) and 28 patients in urgent care settings. Encounter time spent vs time needed (time pressure) was collected from time stamps and clinician surveys. Study physicians completed surveys on stress, burnout, and work conditions using the Mini-Z survey.

Results

Physicians with high stress or burnout were less likely to record psychosocial information in transcripts and notes (psychosocial information noted in 0% of encounters in 4 high stress/burned-out physicians), whereas low stress physicians (n=3) recorded psychosocial information consistently in 67% of encounters. Burned-out physicians discussed a differential diagnosis in only 31% of encounters (low counts concentrated in two physicians) vs. in 73% of non-burned-out doctors’ encounters. Burned-out and non-burned-out doctors spent comparable amounts of time with patients (about 25 min).

Conclusions

Key diagnostic elements were seen less often in encounter transcripts and notes in burned-out urgent care physicians.
Examining the effect of Helicobacter pylori cagPAI variety on gene expression pattern related to gastric cancer
Authors: Ahmadzadeh Alireza , Rashidi Mohsen , Mohsenifar Zhaleh , Faeghi Fariborz , Rezaei-Tavirani Mostafa , Ahmadi Nayebali , Zali Mohammad Reza , Alebouyeh Masoud , feizi Mehdi , Ahmadzadeh Zobayde
Published: March 2023

Objectives

We aimed to determine possible association between heterogeneity of Helicobacter pylori cytotoxin-associated gene pathogenicity island and gene expression profiles in patients with distinct histopathological changes.

Methods

Gastric biopsies were obtained from seventy five patients. Microbiological and pathological examinations were done and intactness of Helicobacter pylori cagPAI was determined by PCR using 11 pairs of primers flanking cagζ-cagA regions and cagPAI empty site. Alterations at mRNA levels of eight genes were investigated by real-time PCR and their association with cagPAI intactness and histopathological changes examined statistically.

Results

A larger proportion of cagPAI positive strains colonized patients with SAG (52.4%), followed by CG (33.3%), and IM (14.3%). Intact cagPAI was found in 87.5% of the strains obtained from patients with SAG, while significantly lower frequency was detected among those with CG (12.5%) and IM (0%). No significant difference was found among the studied histological groups and fold changes in gene expression of gastric biopsies of Helicobacter pylori infected patients with distinct cagPAI status. However, in each histological group, the strains with more complete gene cluster induced (ErbB2, CCNE1, CTNNB1, and MMP7 in SAG and IM groups) or reduced (TP53, in CG group) expression of the GC associated genes in relatively higher levels. APC, TP53 and E-cadherin were down-regulated in patients with SAG and IM compared with CG patients, irrespective to the status of cagPAI integrity.

Conclusions

Helicobacter pylori strains that carry more complete cagPAI segment could induce remarkably higher levels of mRNA changes of GC associated genes in all histopathological groups.
The different effects of the ideal L2 self and intrinsic motivation on reading performance via engagement among young Chinese second-language learners
Authors: Zhu Xinhua , Chan Shui Duen , Yao Yuan , Zhu Siyu
Published: March 2023

Although motivational variables have been extensively examined in the context of English as a second/foreign language (ESL/EFL), they have received little attention when learning Chinese as a second language (CSL), especially among elementary school students in lower grades. Considering the significant impact of psychological variables on language learning and the dilemma of Chinese reading for non-Chinese speaking (NCS) students from Hong Kong, this study examined the structural relationship between the ideal L2 self and intrinsic motivation, as well as their impacts on the learning engagement and reading performance of 475 Hong Kong first-grade NCS students. Two findings were noteworthy: (1) under the simultaneous consideration of the above-mentioned variables, intrinsic motivation affects learning engagement and Chinese reading performance more than the ideal self; (2) the indirect effects of intrinsic motivation on reading performance through learning engagement are more significant than its direct effect on reading performance. The implications of the findings are discussed.
Angry lions and scared neighbors: Complex demonstrations in sign language role shift at the sign-gesture interface
Authors: Steinbach Markus
Published: March 2023

Sign languages make use of the full expressive power of the visual-gestural modality to report the utterances and/or actions of another person. A signer can shift into the perspective of one or more persons and reproduce the utterances or actions from the perspective of these persons. This modality-specific device of utterance and action report is called role shift or constructed action. Especially in sign language narration, role shift is a productive and expressive means that can be used to demonstrate linguistic and non-linguistic actions. Recent developments in sign language linguistics put forth new formal semantic analyses of role shift at the interface between sign language and gesture, integrating insights from classical cognitive and formal analyses of quotation, demonstration and perspective/context shift in spoken and sign languages. In this article, I build on recent accounts of role shift as a modality-specific device of demonstration and show that a modified version of this theory even accounts for cases of complex demonstrations including hybrid demonstrations, multiple demonstrations and demonstrations involving a complex interaction of gestural and linguistic components.
Mormoopid bats from Brazil: updates on the geographic distribution of three species and their echolocation calls
Authors: Falcão Fábio , Pavan Ana Carolina
Published: March 2023

Mormoopids are a small group of insectivorous bats largely distributed from the southwestern United States throughout Central and South America. They occupy a wide variety of habitats, and in Brazil have usually been associated with habitats in the Amazon, Cerrado, or Caatinga biomes. Nevertheless, most of the information compiled so far to infer their distributional limits is based on roosting colonies occasionally found in caves or on inventories using bat mist netting, which is known to be an ineffective method for capturing aerial insectivorous bats. In this contribution, we present new occurrence records of mormoopid bats based on acoustic surveys in the Caatinga and Cerrado biomes and make an extensive literature review to provide an up-to-date distribution of these bats in Brazil. We additionally describe important parameters of the echolocation calls of mormoopids across the geographical scope of our study, contrasting our data with published information to provide a better overview of the intraspecific acoustic variation of these bat species. Our acoustic data reveal a larger area of occurrence of mormoopids in Brazil than previously known, confirming new records for two states.
Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
Authors: Liu Rong , Yang Junlin , Zhang Wei , Li Xiaobo , Shi Dai , Cai Wu , Zhang Yue , Fan Guohua , Li Chenglong , Jiang Zhen
Published: March 2023

Our purpose was to devise a radiomics model using preoperative computed tomography angiography (CTA) images to differentiate new from old emboli of acute lower limb arterial embolism. 57 patients (95 regions of interest; training set: n = 57; internal validation set: n = 38) with femoral popliteal acute lower limb arterial embolism confirmed by pathology and with preoperative CTA images were retrospectively analyzed. We selected the best prediction model according to the model performance tested by area under the curve (AUC) analysis across 1,000 iterations of prediction from three most common machine learning methods: support vector machine, feed-forward neural network (FNN), and random forest, through several steps of feature selection. Then, the selected best model was also validated in an external validation dataset (n = 24). The established radiomics signature had good predictive efficacy. FNN exhibited the best model performance on the training and validation groups: its AUC value was 0.960 (95% CI, 0.899–1). The accuracy of this model was 89.5%, and its sensitivity and specificity were 0.938 and 0.864, respectively. The AUC of external validation dataset was 0.793. Our radiomics model based on preoperative CTA images is valuable. The radiomics approach of preoperative CTA to differentiate new emboli from old is feasible.
Reinventing Multilateralism: What to Do, What to Study, and Why
Authors: Ang Yuen Yuen
Published: March 2023

The current system of multilateralism, borne out of circumstances after the Second World War, is no longer fit for purpose today. How should this system be reinvented, and what types of research can contribute to its reform? First, it is not enough to tell international organizations that they ought to do more of the same good things such as transparency and engagement; rather, we need contextually grounded and publicly engaged research that helps practitioners dispel tropes and elevate public discourse in a deeply politicized world. Second, being public in nature, international organizations cannot be expected to operate like private firms. Any prescription must take into account their political imperatives. Publicly engaged research on multilateralism should move in three directions: (a) take US-China great power competition as a necessary starting point; (b) support ethnographic and empirical research that sheds light on internal operations, political dynamics, and constraints within international organizations; (c) promote dialogues between academics and practitioners, as this special collection has done.
Low hanging fruit for combatting SARS‐CoV‐2?
Authors: Cantoni Diego , Grove Joe
Published: March 2023

Entry of SARS‐CoV‐2 into human respiratory cells, mediated by the spike protein, is absolutely dependent on the cellular receptor ACE2 (angiotensin‐converting enzyme‐2). This makes ACE2 an attractive target for therapeutic intervention in COVID‐19. In this issue, Zuo et al. discover that vitamin C, an essential nutrient and common dietary supplement, can target ACE2 for ubiquitin‐dependent degradation, resulting in the inhibition of SARS‐CoV‐2 infection (Zuo et al, 2023). The study identifies novel mechanisms of cellular ACE2 regulation and may inform the design of therapeutics targeting SARS‐2 and related coronaviruses.
From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors
Authors: Kryza David , Wischhusen Jennifer , Richaud Mathieu , Hervieu Maëva , Sidi Boumedine Jacqueline , Delcros Jean‐Guy , Besse Sophie , Baudier Thomas , Laval Pierre‐Alexandre , Breusa Silvia , Boutault Erwan , Clermidy Hugo , Rama Nicolas , Ducarouge Benjamin , Devouassoux‐Shisheboran Mojgan , Chezal Jean‐Michel , Giraudet Anne‐Laure , Walter Thomas , Mehlen Patrick , Sarrut David , Gibert Benjamin
Published: March 2023

Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells, targeting membrane‐bound cancer‐specific moieties. Here, we report the embryonic navigation cue netrin‐1 as an unanticipated target for vectorized radiotherapy. While netrin‐1, known to be re‐expressed in tumoral cells to promote cancer progression, is usually characterized as a diffusible ligand, we demonstrate here that netrin‐1 is actually poorly diffusible and bound to the extracellular matrix. A therapeutic anti‐netrin‐1 monoclonal antibody (NP137) has been preclinically developed and was tested in various clinical trials showing an excellent safety profile. In order to provide a companion test detecting netrin‐1 in solid tumors and allowing the selection of therapy‐eligible patients, we used the clinical‐grade NP137 agent and developed an indium‐111‐NODAGA‐NP137 single photon emission computed tomography (SPECT) contrast agent. NP137‐111In provided specific detection of netrin‐1‐positive tumors with an excellent signal‐to‐noise ratio using SPECT/CT imaging in different mouse models. The high specificity and strong affinity of NP137 paved the way for the generation of lutetium‐177‐DOTA‐NP137, a novel vectorized radiotherapy, which specifically accumulated in netrin‐1‐positive tumors. We demonstrate here, using tumor cell‐engrafted mouse models and a genetically engineered mouse model, that a single systemic injection of NP137‐177Lu provides important antitumor effects and prolonged mouse survival. Together, these data support the view that NP137‐111In and NP137‐177Lu may represent original and unexplored imaging and therapeutic tools against advanced solid cancers.
Evaluando el conocimiento especializado para enseñar estadística y probabilidad: Elaboración y validación del Cuestionario MTSK-estocástico
Authors: Franco Seguí Joan , Alsina Ángel
Published: March 2023

[Objetivo] En esta investigación se presenta el proceso de construcción y validación del Cuestionario MTSK-estocástico. [Metodología] A través de un proceso que consta de tres fases: 1) revisión bibliográfica; 2) construcción de la versión final; 3) validación a través del juicio de expertos y la posterior aplicación piloto, se construye un cuestionario abierto para analizar y evaluar aspectos del conocimiento especializado del profesorado de Educación Primaria en activo para enseñar estadística y probabilidad, con base en el Modelo del conocimiento especializado del profesorado de Matemáticas (MTSK) y el Enfoque de los itinerarios de enseñanza de las matemáticas (EIEM). [Resultados] Las puntuaciones de las evaluaciones y opiniones expertas han proporcionado una valoración general positiva, no obstante, se eliminaron algunos ítems y se reformularon otros para mejorar su claridad y comprensión. [Conclusiones] La versión final del cuestionario, que consta de 5 ítems para el análisis de la estadística y 5 ítems para la probabilidad, permite aportar certezas sobre el dominio del conocimiento matemático: conocimiento de los temas, el conocimiento de la estructura matemática, el conocimiento de la práctica matemática; y sobre el dominio del conocimiento didáctico: el conocimiento de los estándares de aprendizaje, el conocimiento de las características de aprendizaje y, finalmente, el conocimiento de la enseñanza de las matemáticas.
Rubén Darío en Italia (septiembre-octubre de 1900)
Authors: Fernández Teodosio
Published: March 2023

La Biblioteca Hispánica de la AECID conserva una valiosa colección de documentos relacionados con Rubén Darío, casi unánimemente ignorados por quienes se han ocupado del poeta nicaragüense. Entre esos documentos se cuentan algunos relacionados con el viaje que Darío hizo a Roma en 1900 como enviado del diario La Nación de Buenos Aires, para informar sobre el Año Santo que entonces se celebraba. Son los que sirven aquí para precisar los pormenores de ese viaje, de notable importancia en su vida y en su obra.
Mechanical properties of paper saturated with a hydrophobic ionic liquid
Authors: Helbrecht Christiane , Schmitt Fabian , Meckel Tobias , Biesalski Markus , Etzold Bastian J. M. , Schabel Samuel
Published: March 2023

Research into paper-based devices and ionic liquids has increased considerably in the past few years. Thus, the combination of paper-based devices with ionic liquids is also becoming an increasingly frequent research subject. However, the influence of the ionic liquid on the paper properties has been hardly considered. In this paper, the influence of a hydrophobic ionic liquid (1-butyl-3-methylimidazolium bis(trifluoromethyl-sulfonyl)imide) on the mechanical properties of laboratory paper, isotropic and oriented, made from eucalyptus sulfate and cotton linters, is investigated. The tensile strength, elastic modulus, and breaking strain of papers saturated with ionic liquid were about 60 to 90% of the dry paper characteristics. In contrast to water, the breaking strain did not increase in the presence of the ionic liquid. This is because the ionic liquid only slightly swelled the fibers.
Archivare zwischen Kaiserreich und Weimarer Republik. Institutionen, Schriftgut, Geschichtskultur
Authors: Schäfer Udo , Herrmann Sabine , Kahuda Jan , Kretzschmar Robert , Just Thomas , Reininghaus Wilfried , Kriese Sven , Schenk Dietmar
Published: March 2023

Der vorliegende Band versammelt die Beiträge der Tagung „Weimars (un)getreue Archivare?“, die am 26. und 27. November 2020 als gemeinsame Tagung der Universität Hamburg und des Staatsarchivs Hamburg stattfand.
Archivgeschichte wird in der Weimarer Republik oft von ihrem Ende her, von den persönlichen Kontinuitäten und Diskontinuitäten nach 1933, gedacht. Im vorliegenden Band wird die Zäsurerfahrung 1918/19, die das Ende des wilhelminischen Kaiserreiches markierte, ins Zentrum der Diskussion gestellt. Welche theoretischen, methodischen und personalpolitischen Einschnitte im Archivwesen gingen mit der politischen Neukonfigurierung unter föderalen und republikanischen Vorzeichen einher? Aufgezeigt wird die Heterogenität der staatlichen und nichtstaatlichen Archivlandschaft im Kaiserreich wie auch in der Weimarer Republik. Diese blieb in ihrer Komplexität erhalten und war – in Weimar – von Konflikten gekennzeichnet, in deren Zentrum nicht selten die archivalische Überlieferung selbst stand.
Die Beiträge verfolgen daher weniger das Ziel zu erklären, wie aus Weimars Archivaren Nationalsozialisten oder Gegner des Nationalsozialismus wurden; stattdessen spüren sie ausgehend von den zentralen oft mannigfaltig verbundenen Akteuren der Reaktion von Archivaren auf den „Systemwechsel” 1918/19 und ihrer gesellschaftlichen Positionssuche in der Weimarer Republik nach.
Materias primas del arte olmeca: De los recursos naturales a los símbolos
Authors: Morante López Rubén Bernardo
Published: March 2023

Los olmecas fueron una cultura prístina que creció al sur de México a partir del año 1600 a.C. El inconfundible estilo de sus creaciones, que se han hallado en gran parte del territorio de Mesoamérica, los ha identificado. Este estudio parte de los materiales pétreos que usaron los olmecas para esculpir obras artísticas, donde vemos la evolución de un estilo estético singular que parte de una selección estratégica de rocas. Los datos e hipótesis de especialistas complementan los estudios aquí aportados para especificar los recursos naturales, el esfuerzo para obtenerlos y las rutas y técnicas de transporte de materias primas y productos terminados. Con nuestro escrito buscamos reforzar y revitalizar la hipótesis de que los olmecas, a la par de la búsqueda de la belleza, tuvieron un claro interés en difundir un discurso ideológico.
La voix de l’Autre. Singularités et altérités vocales dans les contacts entre Byzantins et leurs voisins occidentaux (IXe-XIIe s.)
Authors: Drocourt Nicolas
Published: March 2023

Even though our sources globally make it difficult to hear the voices of individuals during the mid-Byzantine period, some of them give us a few insights, notably when Byzantine authorities are confronted with Western neighbours. Indeed, Byzantine singing and liturgic practices are frequently mentioned in Latin sources. They are often associated with other aspects of what one may call a “sound landscape”, and they are presented in a positive manner. But laughter and pronunciation are vocal variations that are usually more criticized in the perception ‘Latins’ and Byzantines have of each other. Furthermore, when political and military tensions arise, variations in the tone of voice of the Other can be severely judged and condemned. Finally, very often, voices heard within the context of encounters between ‘Latins’ and ‘Greeks’ may be associated with questions of order and disorder according to Byzantine authors.
Evolutes of Conics in the Pseudo-Euclidean Plane
Authors: Božić Dragun Ivana
Published: March 2023

The evolute of a conic in the pseudo-Euclidean plane is the locus of centers of all its osculating circles. It’s a curve of order six and class four in general case. In this paper we discuss and compute the order and class of evolutes of different types of conics. We will highlight those cases that have no analogy in the Euclidean plane.
Determinant Inequalities for Positive Definite Matrices via Cartwright–Field’s Result for Arithmetic and Geometric Weighted Means
Authors: Dragomir Silvestru Sever
Published: March 2023

Assume that Aj, j ∈ {1, … , m} are positive definite matrices of order n. In this paper we prove among others that, if 0 < l In ≤ Aj, j ∈ {1, … , m} in the operator order, for some positive constant l, and In is the unity matrix of order n, then

where Pk ≥ 0 for k ϵ {1, …, m} and .
Optimizing chemistry for designing oxidation resistant FeCrAl alloys
Authors: Roy Indranil , Abouelella Hamdy , Umretiya Rajnikant V. , Roychowdhury Subhrajit , Feng Bojun , Ravi Sandipp Krishnan , Ghosh Sayan , Rebak Raul B. , Ruscitto Daniel M. , Gupta Vipul , Hoffman Andrew
Published: March 2023

Traditionally, FeCrAl alloys played an important role in high-temperature applications due to their ability to form a passive Al oxide film at temperatures above ~ 800 °C. Recently, FeCrAl alloys became of interest for the application of accident tolerant nuclear fuel cladding. This study covers work done at GE Research for better understanding the role of Al, Cr, and Mo in oxidation kinetics and thermodynamics. Several models and commercial prototype alloys have been tested in hydrothermal corrosion autoclave loops, at low temperature steam exposure (~ 400 °C), high temperature steam exposure (~ 1000 °C or higher), and high temperature air exposures. The results provide insights on how chromium and aluminum play a significant role in both high temperature and low temperature oxidation of FeCrAl. Additionally, machine learning tools are used to gain further insights on both predicting future optimized chemistries for balancing the properties of hydrothermal corrosion, low and high temperature steam oxidation, and thermal aging (which is exacerbated due to radiation in a nuclear reactor environment). GE plans to use this framework to further optimize the FeCrAl alloy system for use in nuclear reactor environments.

Graphical abstract
The Buddhasothorn Asthma Severity Score (BASS): A practical screening tool for predicting severe asthma exacerbations for pediatric patients
Authors: Ittiporn Suttipong , Prajongdee Kanlaya
Published: March 2023

Background and aim: A precise scaling system of acute asthma leads to an accurate assessment of disease severity. This study aimed to compare the accuracy of the Buddhasothorn Asthma Severity Score (BASS) with the Wood–Downes–Ferrés Scale (WDFS) to recognize the severity level of acute asthma.
Materials and methods: A cross-sectional study was conducted comprising Thai children aged 2–15 years with acute asthma. The BASS and WFDS were rated once in the emergency department. The degree of severity was determined by frequency and type of nebulized bronchodilator administrations at the time of initial treatment. The optimum cutoff points for the area under the curve (AUC) were established to predict severe asthma exacerbations.
Results: All 73 episodes of asthma exacerbations (EAEs) in 35 participants were analyzed. Fifty-nine (80.8%) EAEs were classified as severe. Both scales had good significance to recognize the selection of nebulized bronchodilator treatments by AUC of 0.815 (95% Confidence Interval [CI]: 0.680–0.950) in case of BASS, and AUC of 0.822 (95% CI: 0.70–0.944) in case of WDFS. Cutoff points of BASS ≥ 8 had sensitivity 72.9%, specificity 64.3%, positive predictive value (PPV) 89.6%, negative predictive value (NPV) 36.0% at an AUC of 0.718 (95% CI: 0.563–0.873) for severe exacerbations. These results were consistent for cutoff points of WDFS ≥ 5 with sensitivity 78.0%, specificity 50.0%, PPV 86.8%, NPV 35.0% at an AUC of 0.768 (95% CI: 0.650–0.886) for predicting severe exacerbations. There was no significant difference between the AUCs of both scales.
Conclusions: Both the BASS and WDFS were good and accurate scales and effective screening tools for predicting severe asthma exacerbations in pediatric patients by optimal cutoff points.
Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis
Authors: Gao Kun , Lv Aiai , Zhang Qiang , Li Yanzhong , Yue Zhiyong , Xu Shuai
Published: March 2023

Purpose: The purpose is to confirm whether long noncoding RNA HOXA-AS2 relieves chronic intermittent hypoxia (CIH)-induced lung inflammation.
Methods: Male Sprague Dawley rats were used to establisha CIH rat model. Hematoxylin and Eosin staining was used on the lung tissue injury to determine the successful construction of CIH animal model. Arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2) were measured. HOXA-AS2 was overexpressed to evaluate its role in the progression and development of CIH. T cell differentiation and cytokine production were determined using flow cytometry. Cell apoptosis was determined using terminal deoxynucleotidyl transferase dUTP nick end labelling assay kit. The target of HOXA-AS2 and miR-17-5p was predicted by the Encyclopedia of RNA Interactomes (ENCORI) and confirmed using luciferase assay.
Results: HOXA-AS2 was downregulated in CIH rat models. Lung tissue injury was observed in CIH rats, and the injury was attenuated by the overexpression of HOXA-AS2. PaO2 was reduced and PaCO2 was induced in CIH rats, which was reversed by the overexpression of HOXA-AS2. The overexpression of HOXA-AS2 inhibited CIH-induced cell apoptosis. It also reversed alterations in the levels of interferon gamma (IFNγ), interleukin (IL)-2, IL-6, IL-1β, tumor necrosis factor alpha (TNF-α), and transforming growth factor beta1 (TGF-β1) in rats caused by CIH. The overexpression of HOXA-AS2 prevented the induction in CD4+ IFN-γ+ T cells and reduction in CD4+TGF-β1+ T cells. The overexpression of HOXA-AS2 upregulated tumor necrosis factor-alpha-induced protein 8-like 2 (tipe2) key regulator through directly targeting miR-17-5p. Further experiments proved that tipe2 was the direct target of miR-17-5p.
Conclusion: This study manifested that HOXA-AS2 acted as an anti-inflammatory regulator and protected lung tissue injury from CIH in the rat model; this was mediated by upregulation of tipe2 through directly targeting miR-17-5p. HOXA-AS2 upregulated the expression of tipe2, providing new understanding and therapeutic target for CIH.
LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients
Authors: Shi Yanan , Zhang Guimin , Ji Ran , Zhang Shengchi , Shen Shaobo
Published: March 2023

Objective: Long intergenic noncoding RNA 00632 (LINC00632) regulates nasal inflammation and CD4+ T cell differentiation into T helper (Th) 2 cells in allergic rhinitis (AR). This study aimed to explore the relationship between LINC00632 and Th1/Th2 balance, and the clinical value of LINC00632 in AR patients.
Methods: In total, 120 AR patients, 20 non-atopic obstructive snoring patients as disease controls (DCs), and 20 healthy controls (HCs) were recruited. Their LINC00632 expressions in peripheral blood mononuclear cells were detected by RT-qPCR.
Results: LINC00632 expression was declined in AR patients compared with DCs and HCs (both P ˂ 0.001). Moreover, LINC00632 could distinguish AR patients from DCs with an area under curve (AUC) of 0.795 (95% confidence interval [CI]: 0.701–0.889), and from HCs with an AUC of 0.895 (95%CI: 0.831–0.960). LINC00632 was positively related to Th1 cells (P = 0.037) and Th1/Th2 axis (P ˂ 0.001) in AR patients. In addition, LINC00632 was inversely associated with Th2 cells (P ˂ 0.001) and interleukin (IL)-4 (P = 0.010) in AR patients. Besides, LINC00632 was negatively related to rhinorrhea score (P = 0.019), itching score (P = 0.008), sneezing score (P = 0.004), and total nasal symptom score (TNSS) (P ˂ 0.001), but no correlation between LINC00632 and congestion score was observed (P = 0.093). During treatment, LINC00632 was elevated, while TNSS score was reduced (both P ˂ 0.001). Furthermore, LINC00632 increment was associated with the reduction of TNSS score during the therapy (P = 0.005).
Conclusion: LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response during 4-week therapy in AR patients.
SOCIAL BUSINESS AND SUSTAINABILITY
Authors: Sugahara Cibele Roberta , Massaioli Marina Ardito , Ferreira Denise Helena Lombardo
Published: March 2023

Social entrepreneurship aims to seek alternatives to the social problems of the community, with the creation of social value. Organizations called Social Businesses seem to have an environment with a greater focus on social innovation, as they seek the solution to a social problem in an effective and sustainable way. Initiatives by individual entrepreneurs, community or institutional seem to be a way to search for a better condition of social well-being. In this sense, the objective of this study is to identify which aspects contribute to the sustainability of Social Business. The methodology used is bibliographic and documentary research with case study, with qualitative approach. The chosen case study was the Artemísia social impact business accelerator. The selected Social Businesses were: So + Ma, Social Symbiosis, Quero Quitar!, Online Writing. In the social field, the offer of products and services at affordable prices contributes to the democratization and access of the low-income population. The creation of a Social Business benefits the entrepreneur, the investor and society, expands access to the market and can assist in the generation of jobs. Thus, it is believed that Social Business can contribute to social transformation and the solution of social problems.
Ekonomiczne i społeczne aspekty rozwoju dawnej Rusi
Authors:   Uniwersytet Łódzki, Duraj Natasza
Published: March 2023

The article’s main goal is to present the economic and social aspects of the development of ancient Russia. The paper is devoted to the problem of the formation of the territory of Kievan Rus through the prism of the development of civilization.
Medication reconciliation in pediatrics: a validation of instruments to prevent medication errors
Authors: Aranha Gabriela Almeida , Cruz Andréia Cascaes , Pedreira Mavilde da Luz Gonçalves
Published: March 2023

ABSTRACT Objectives: to develop and validate the content of two instruments for promoting medication reconciliation for the transition of care of hospitalized children. Methods: methodological study, conducted in five stages: scope review for conceptual structure; elaboration of the initial version; content validation with five specialists using the Delphi technique; reassessment; and construction of the final version of the instruments. A content validity index of at least 0.80 was adopted. Results: three rounds of evaluation were carried out to reach the validity index of the proposed contents, whereas a new analysis of 50% of the 20 items of the instrument aimed at families, and 28.5% of the 21 items aimed at professionals was necessary. The instrument aimed at families reached an index of 0.93, and the instrument for professionals, 0.90. Conclusions: the proposed instruments were validated. It is now possible to proceed with practical implementation studies to identify their influence on safety during medication reconciliation at transition of care.
Construct elaboration and validity of the Pregnancy Depression Risk Scale
Authors: Silva Mônica Maria de Jesus , Santos Claudia Benedita dos , Clapis Maria José
Published: March 2023

ABSTRACT Objectives: to elaborate and analyze the Pregnancy Depression Risk Scale psychometric properties. Methods: methodological research, in six steps: theoretical model empirical definition; elaboration of scale items with literature review; consultation with five professional health experts and 15 pregnant women; content validity with six experts; pre-test-semantic validity with 24 pregnant women; scale factor structure definition with 350 pregnant women; pilot study with 100 pregnant women, totaling 489 pregnant women and 11 experts. Data were analyzed by content analysis, exploratory factor analysis, multitrait-multimethod analysis and internal consistency. Results: sixty-eight risk factors were identified for item formulation. The final version of the scale consisted of 24 items in five domains. The scale demonstrated satisfactory construct content, semantic, validity and reliability. Conclusions: the scale proved to be valid in terms of content and semantics, with a factor structure defined according to the adopted theoretical model and satisfactory psychometric properties.
Estratégias de cuidados paliativos no manejo de pessoas com casos graves da COVID-19
Authors: Prado Eleandro do , Camparoto Camila Wohlenberg , Takemoto Angelica Yukari , Ichisato Sueli Mutsumi Tsukuda , Miguel Maria Emília Grasso Busto , Marcon Sonia Silva
Published: March 2023

RESUMO Objetivos: analisar as estratégias assistenciais em cuidados paliativos desenvolvidas na pandemia de COVID-19 aos pacientes graves e familiares. Métodos: revisão integrativa, realizada em agosto de 2021 e atualizada em abril de 2022, nas bases de dados Base de Dados de Enfermagem (BDENF), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System Online (MEDLINE), US National Library of Medicine (PubMed), Web of Science, e apresentadas no fluxograma PRISMA. Resultados: foram selecionados treze trabalhos para leitura e análise de conteúdo, dos quais emergiram as duas principais temáticas que traduzem a realidade evidenciada neste contexto: O advento súbito da COVID-19 com impactos nos cuidados paliativos; e, As estratégias utilizadas em cuidados paliativos para amenizar esses impactos. Considerações Finais: os cuidados paliativos se convergem na melhor estratégia de prestação de atendimento à saúde, usados como um acalento para trazer alívio e conforto aos pacientes e às famílias.
The self-care process of community-dwelling older adults during the COVID-19 pandemic
Authors: Lopes Larissa Padoin , Santi Daniela Bulcão , Marques Francielle Renata Danielli Martins , Salci Maria Aparecida , Carreira Lígia , Baldissera Vanessa Denardi Antoniassi
Published: March 2023

ABSTRACT Objectives: to understand the self-care process of community-dwelling older adults during the COVID-19 pandemic. Methods: this is an explanatory study with a qualitative approach based on the constructivist Grounded Theory, carried out with 18 community-dwelling older adults. Data collection took place through interviews and content was analyzed through initial and focused coding. Results: two categories were obtained: “Building connections to support self-care practices” and “Living with the risk group stigma”. From their interaction, the phenomenon “Performing self-care in old age during the COVID-19 pandemic” emerged. Final Considerations: it was possible to identify how older adults’ experiences curing the COVID-19 pandemic had repercussions on their self-care process, being influenced by factors such as information about the disease and the impacts of risk group stigmas.
Luz, câmera, cocriação: o cinema documentário como inspiração para descolonizar a produção de conhecimentos
Authors: Fasanello Marina Tarnowski , Porto Marcelo Firpo
Published: March 2023

RESUMO O artigo discute o papel do cinema documentário como inspiração para o desenvolvimento de metodologias sensíveis co-labor-ativas em campos interdisciplinares como a saúde coletiva, envolvendo a aproximação entre cientistas, cineastas e movimentos sociais em torno de problemas de saúde e ambiente. O artigo ancora-se na noção de tornar comum usada por Paulo Freire, e na obra de Boaventura de Sousa Santos denominada de epistemologias do Sul e sua proposta para descolonizar o conhecimento, o que inclui a realização de ecologias de saberes. A partir de tais referenciais, o documentário é refletido para além de uma obra artística e autoral apoiado na ciência, mas enquanto emergência de novas epistemes e saberes conectados a lutas sociais e processos emancipatórios que podem inspirar a renovação teórico-metodológica na produção de conhecimentos. No artigo, selecionaram-se dois documentários que versam sobre as lutas contra a agricultura capitalista e os efeitos do uso intensivo de agrotóxicos, assim como a promoção da agroecologia e da reforma agrária como alternativas para sociedades mais justas, saudáveis e sustentáveis. Como resultado, a análise de tais documentários demonstra o potencial de reunir ciência, política, arte e ética enquanto práticas interdisciplinares e interculturais de co-labor-ação, coprodução e cocriação.
Effectiveness of the law on priority for the elderly in health claims in Rio de Janeiro
Authors: Azevedo Aldilene Abreu de , Girianelli Vania Reis , Bonfatti Renato José
Published: March 2023

ABSTRACT The growth of older adults is a global event. The study aimed to evaluate the effectiveness of the law on priority for the elderly in relation to the procedural processing of health claims made in the Lower Courts of Justice of the judicial district of the Capital of Rio de Janeiro State. A descriptive cross-sectional study of the proceedings assigned in the period from 2018 to 2019 was conducted. The total sample included 1,040 identified cases, but only 240 were eligible (23%). Most claims were related to home care services (26.3%), particularly for adults aged 80 years and over (54.7%). The legal effectiveness of the law for the 60- to 79-year-old age group was 86% and 97.3% for other elderly people. The processing time of the lawsuits, however, was shorter for mature adults than for older people (p=0,020) and similar between older adults aged 80 years or above and other elderly adults (p=0,400). Monitoring the impact of this law on society is essential, older people are at a stage of life in which the issue of time is essential, particularly when the claim is related to health.
Repercussões no cotidiano de crianças e adolescentes que viveram com hanseníase
Authors: Vieira Michelle Christini Araújo , Teixeira Maria da Glória Lima Cruz , Silva Luís Augusto Vasconcelos da , Mistura Claudelí , Sarmento Sued Sheila , Mascarenhas Aline Araújo
Published: March 2023

RESUMO O estudo apresenta como objetivo compreender as repercussões da doença na vida cotidiana de crianças e adolescentes acometidos pela hanseníase. Trata-se de uma pesquisa qualitativa com base no referencial teórico ‘A Sociologia de Erving Goffman’. Foram entrevistados, individualmente, 14 participantes, sendo 9 crianças e 5 adolescentes tratados e curados da hanseníase. Utilizou-se entrevista semiestruturada, abrangendo informações sociodemográficas e questões norteadoras sobre a vivência dos participantes com a doença, aspectos familiares, sociais e percepções advindas da experiência. Os dados foram analisados pela sociologia de Erving Goffman. As narrativas enfatizam as repercussões do cotidiano relacionados com a história da descoberta da hanseníase, as redes de interação como família e profissionais de saúde, dos cuidados com a própria saúde, de estratégias de superação e expectativas. Verificou-se que o elemento predominante da pesquisa se ancora no temor de ser descoberto e desacreditado, na perspectiva de ter sua identidade de sadio ressignificada, pelo adoecimento e perante a vivência dos participantes com o preconceito, sigilo e segredo. Conclui-se, de modo simbólico, que os participantes vivenciaram uma construção de vida social negativa em torno da hanseníase. O adoecimento interfere de modo direto no cotidiano e desenvolvimento dos participantes, repercutindo principalmente nas relações sociais.
Evidência de validade da Escala de Literacia em Saúde e eHEALS para idosos
Authors: Oliveira Leonardo Pestillo de , Souza Rosane Clys Barros , Barros Josiane Kelly de , Moura Giovana Mioto de , Yamaguchi Mirian Ueda
Published: March 2023

RESUMO O presente artigo busca apresentar evidências de validade de dois instrumentos, Literacia em Saúde e Literacia Digital em Saúde para utilização em idosos e avaliar suas propriedades psicométricas, por meio de um estudo com método descritivo, quantitativo e transversal, realizado com 379 participantes idosos, que responderam aos questionários: a) sociodemográfico, b) Escala de Literacia em Saúde e c) electronic Health Literacy Scale (eHEALS). Foram realizadas análises fatoriais exploratória e confirmatória, com validade convergente dos fatores que foram estimadas por meio da Variância Média Extraída e Confiabilidade Composta, tendo como resultados a apresentação dos instrumentos com cargas fatoriais adequadas (> 0.4), além de confiabilidade adequada (> 0.7). A validade externa testada pela correlação entre os dois instrumentos apresentou correlação estatisticamente significante, positiva e moderada (r = 0.35; p< 0.001), indicando evidências de validade e consistência na Escala de Literacia em Saúde para uso em idosos, e atestando ao instrumento eHEALS confiabilidade adequada e válida para o público idoso brasileiro.
A interdisciplinaridade na construção da Educação Permanente em Saúde com equipes gestoras
Authors: Ferraz Edinalva de Moura , Mendonça Fernanda de Freitas , Carvalho Brígida Gimenez , Santini Stela Maris Lopes , Almeida Elisabete de Fátima Polo de , Silva João Felipe Marques da , Andrade Silvia Karla Azevedo Vieira
Published: March 2023

RESUMO A gestão no Sistema Único de Saúde (SUS) requer das equipes gestoras a compreensão e o desenvolvimento de um conjunto de habilidades e competências que os auxiliem no cotidiano e nos desafios da gestão pública. Este artigo apresenta um processo de Educação Permanente em Saúde (EPS) desenvolvido com equipes gestoras de duas regiões de saúde do Paraná, com intuito de ampliar o olhar dos participantes para a reorganização da gestão e da implementação do SUS no território, pautado na interdisciplinaridade. Trata-se de um relato de experiência desenvolvido com equipes gestoras, realizada no ano de 2019, apresentado em cinco seções: a primeira descreve o contexto em que a experiência foi desenvolvida, elucidando motivos, atores e a localidade em que ocorreu; a segunda apresenta a proposta de trabalho, a confecção das oficinas e os recursos metodológicos utilizados; a terceira relata o caminho percorrido na sua operacionalização; a quarta discute as características de interdisciplinaridade existentes no processo de EPS e a última apresenta algumas considerações. A proposta mostra-se como uma potente estratégia para promover o diálogo entre diferentes atores e instituições, principalmente no contexto de crise sanitária e fiscal do Estado, qualificar e tornar reflexivo o trabalho no campo da gestão em saúde.
Solidarity economy and mental health: experience report of virtual practices
Authors: Santos Chaiane , Portugal Clarice , Nunes Mônica
Published: March 2023

ABSTRACT The connection between mental health and work has a long trajectory, often involving oppression and restriction of freedom. Seeking a new place of work for users of the Psychosocial Care Network (RAPS), the solidarity economy has been highlighted as a multiple possibility in the fight against the stigma, emphasizing people’s autonomy and emancipation through solidarity and cooperativism. Thus, this article aims to bring an interprofessional experience report on a universitary extension project of Solidarity Economy in Mental Health. This is a descriptive work, developed based on participant observation and analyzed in the light of Mikhail Bakhtin and Paulo Freire. It is concluded that this project is of paramount importance in the construction of multiple knowledge, as it includes professionals in the plastic and performing arts, health, and artisans. Thus, the training practice of several actors contemplates a powerful action through art, culture, and work for a management that aims at social inclusion, critical reflection, and autonomy in the field of mental health.