bluuebunny/crossref_metadata_2025 huggingface dataset:
The status of the oblique possessor in BE-possessives: Evidence from Russian and Hungarian
Authors: Dalmi Gréte
Published: November 2021

This comparative syntactic study claims that the possessor of Russian and Hungarian BE-possessives neither originates nor lands in [Spec,VoiceP], the designated structural position of external arguments since Kratzer (1996). Possessive sentences universally describe a state with two eventuality participants, the possessor and the possessee (Stassen 2009). BE-possessives are built on dyadic-unaccusative existential BE. Neither of its two eventuality participants passes the agent/cause tests provided by Alexiadou, Anagnostopoulou & Schäfer (2015). It is claimed here that possessive BE-sentences in Russian and Hungarian pattern with thepiacere-subclass ofpsych-predicates, inasmuch as the possessor bears the oblique case and the theme appears in the nominative in them. In the cartographic model, the oblique experiencer of thepiacere-type ofpsych-predicates targets a position higher than canonical, agent/cause subjects do (see Cardinaletti 1997, 2004; Rizzi 1997, 2004 for Italian). This paves the way for oblique possessors and non-canonical subjects to appear in positions left-adjacent to the designated position for canonical, nominative subjects (see Cardinaletti 1997, 2004 for Italian; Benedicto 1995; Livitz 2006, 2012 for Russian; Dalmi 2000, 2005 for Hungarian). Possessive BE-predicates in Russian and Hungarian share a number of syntactic and semantic properties with existential BE (see Partee & Borschev 2008 for Russian and Szabolcsi 1992, 1994 for Hungarian). Nonetheless, BE-possessives and BE-existentials differ in the two languages in their clausal architecture, due to the fact that EPP is fulfilled in different ways in them.
Essential oils ofUvaria boniana – chemical composition,in vitrobioactivity, docking, andin silicoADMET profiling of selective major compounds
Authors: Ninh The Son , Le Tuan Anh , Dinh Thi Thu Thuy , Nguyen Dinh Luyen , Tran Thi Tuyen , Pham-The Hai
Published: November 2021

Phytochemical investigation applying GC (gas chromatography)-MS (mass spectrometry)/GC-FID (flame ionization detection) on the hydro-distilled essential oils of the Vietnamese medicinal plantUvaria bonianaleaf and twig lead to the detection of 35 constituents (97.36%) in the leaf oil and 52 constituents (98.75%) in the twig oil. Monoterpenes, monoterpenoids, sesquiterpenes, and sesquiterpenoids were characteristic ofU. bonianaessential oils. The leaf oil was represented by major components (E)-caryophyllene (16.90%), bicyclogermacrene (15.95%),α-humulene (14.96%), and linalool (12.40%), whereas four compoundsα-cadinol (16.16%),epi-α-muurolol (10.19%),α-pinene (11.01%), andβ-pinene (8.08%) were the main ones in the twig oil. As compared with the leaf oil, the twig oil was better in antimicrobial activity. With the same MIC value of 40 mg/mL, the twig oil successfully controlled the growth of Gram (+) bacteriumBacillus subtilis, Gram (−) bacteriumEscherichia coli, fungusAspergillus niger, and yeastSaccharomyces cerevisiae. In addition, both two oil samples have induced antiinflammatory activity with the IC50values of 223.7–240.6 mg/mL in NO productive inhibition when BV2 cells had been stimulated by LPS. Docking simulations of four major compounds ofU. bonianatwig oil on eight relevant antibacterial targets revealed thatepi-α-muurolol andα-cadinol are moderate inhibitors ofE. coliDNA gyrase subunit B, penicillin binding protein 2X and penicillin binding protein 3 ofPseudomonas aeruginosawith similar free binding energies of −30.1, −29.3, and −29.3 kJ/mol, respectively. Furthermore,in silicoADMET studies indicated that all four docked compounds have acceptable oral absorption, low metabolism, and appropriated toxicological profile to be considered further as drug candidates.
Thin-film chemical expansion of ceria based solid solutions: laser vibrometry study
Authors: Wulfmeier Hendrik , Kohlmann Dhyan , Defferriere Thomas , Steiner Carsten , Moos Ralf , Tuller Harry L. , Fritze Holger
Published: November 2021

The chemical expansion of Pr0.1Ce0.9O2–δ
(PCO) and CeO2–δ
thin films is investigated in the temperature range between 600 °C and 800 °C by laser Doppler vibrometry (LDV). It enables non-contact determination of nanometer scale changes in film thickness at high temperatures. The present study is the first systematic and detailed investigation of chemical expansion of doped and undoped ceria thin films at temperatures above 650 °C. The thin films were deposited on yttria stabilized zirconia substrates (YSZ), operated as an electrochemical oxygen pump, to periodically adjust the oxygen activity in the films, leading to reversible expansion and contraction of the film. This further leads to stresses in the underlying YSZ substrates, accompanied by bending of the overall devices. Film thickness changes and sample bending are found to reach up to 10 and several hundred nanometers, respectively, at excitation frequencies from 0.1 to 10 Hz and applied voltages from 0–0.75 V for PCO and 0–1 V for ceria. At low frequencies, equilibrium conditions are approached. As a consequence maximum thin-film expansion of PCO is expected due to full reduction of the Pr ions. The lower detection limit for displacements is found to be in the subnanometer range. At 800 °C and an excitation frequency of 1 Hz, the LDV shows a remarkable resolution of 0.3 nm which allows, for example, the characterization of materials with small levels of expansion, such as undoped ceria at high oxygen partial pressure. As the correlation between film expansion and sample bending is obtained through this study, a dimensional change of a free body consisting of the same material can be calculated using the high resolution characteristics of this system. A minimum detectable dimensional change of 5 pm is estimated even under challenging high-temperature conditions at 800 °C opening up opportunities to investigate electro-chemo-mechanical phenomena heretofore impossible to investigate. The expansion data are correlated with previous results on the oxygen nonstoichiometry of PCO thin films, and a defect model for bulk ceria solid solutions is adopted to calculate the cation and anion radii changes in the constrained films during chemical expansion. The constrained films exhibit anisotropic volume expansion with displacements perpendicular to the substrate plane nearly double that of bulk samples. The PCO films used here generate high total displacements of several 100 nm’s with high reproducibility. Consequently, PCO films are identified to be a potential core component of high-temperature actuators. They benefit not only from high displacements at temperatures where most piezoelectric materials no longer operate while exhibiting, low voltage operation and low energy consumption.
Synaptic Dynamics Convey Differential Sensitivity to Input Pattern Changes in Two Muscles Innervated by the Same Motor Neurons
Authors: Daur Nelly , Nadim Farzan , Bucher Dirk
Published: November 2021

Postsynaptic responses depend on input patterns as well as short-term synaptic plasticity, summation, and postsynaptic membrane properties, but the interactions of those dynamics with realistic input patterns are not well understood. We recorded the responses of the two pyloric dilator (PD) muscles,cpv2aandcpv2b, that are innervated by and receive identical periodic bursting input from the same two motor neurons in the lobsterHomarus americanus.Cpv2aandcpv2bshowed quantitative differences in membrane nonlinearities and synaptic summation. At a short timescale, responses in both muscles were dominated by facilitation, albeit with different frequency and time dependence. Realistic burst stimulations revealed more substantial differences. Across bursts,cpv2ashowed transient depression, whereascpv2bshowed transient facilitation. Steady-state responses to bursting input also differed substantially. Neither muscle had a monotonic dependence on frequency, butcpv2bshowed particularly pronounced bandpass filtering.Cpv2awas sensitive to changes in both burst frequency and intra-burst spike frequency, whereas, despite its much slower responses,cpv2bwas largely insensitive to changes in burst frequency.Cpv2awas sensitive to both burst duration and number of spikes per burst, whereascpv2bwas sensitive only to the former parameter. Neither muscle showed consistent sensitivity to changes in the overall spike interval structure, butcpv2bwas surprisingly sensitive to changes in the first intervals in each burst, a parameter known to be regulated by dopamine (DA) modulation of spike propagation of the presynaptic axon. These findings highlight how seemingly minor circuit output changes mediated by neuromodulation could be read out differentially at the two synapses.
Prerequisites of development of an accessible tourism for everyone in the European Union
Authors: Senkiv Mariana I. , Tserklevych Viktoriia S.
Published: November 2021

Modern approaches of understanding the concepts of accessible tourism for everyone are analyzed in this paper. Accessible tourism for everyone means that anytourism product should be designed irrespective of age, gender and ability, and with no additional costs for customers with disabilities and specific access requirements. The role of the principles of universal design for accessible tourism for everyone is described. In contrast to the concept of accessibility, which only applies to low-mobility categories of the population and focuses on physical access to transport and premises, as well as access to information, the concept of universal design emphasizes creating the same conditions convenient for all users, without impersonating any of them. The connection between accessible tourism for everyone and the goal of sustainable development is revealed. Accessible tourism for everyone significantly contributes to the achievement most of sustainable development goals. Three main prerequisites for the development of accessible tourism for everyone in the European Union are determined and characterized by: existing accessibilitylegislation and standards at the global, European and national levels, population ageing and increase in the number of people with disabilities. In Ukraine there is a lack of accessibility standards for tourism facilities and services. It is important to transfer experiences and knowledge that exists in the European Union to Ukraine and ensure an adapted implementation to local requirements. A map of the most accessible cities of the European Union is created and the quantitative distribution of these cities by country of ownership is presented. Accessible to all tourism chain is analyzed on the example of Ljubljana city in Slovenia, which was twice noted by the European Commission as one of the most accessible.
Imparity in air quality index (Pre - Covid vs Post-Covid): A head-turning review
Authors: Mukherjee Susmita , Biswas Aditi , Mazumder Camellia , Roy Aratrik , Paul Sonali
Published: November 2021

Industrialization and Covid-19 - the two pillars showing the world adverse effects of air pollution and also on the other hand improvement of air index over the globe. During the pre-covid period the world saw industrialization and modernization paving path to air pollution. This 2019
pandemic still on-going did take millions of lives but healed the mother nature thus reducing pollution due to air pollutants (PM 2.5, CO2, NOx, SO2). Such adverse situation and lockdown over the world have taught people self-independence in their lives thus reducing the dependence on technology
and annihilating all the possible pollution due to industrialization and automobiles: the new normal. This review solely focuses on the analysis of air index quality pre versus post covid and thus accepting the new normal for the healing of earth.
Importance of Pre & Probiotic Maintaining General Health: A Report
Authors: Chaudhuri Biswadeep
Published: November 2021

In the market a few items are accessible loaded up with the integrity of prebiotics and probiotics (beneficial microorganisms like great stomach microscopic organisms, parasites), Probiotics are helpful microbes, and prebiotics are nourishment for these microbes. Together they help
in great gastrointestinal system and renal(kidney) wellbeing. They likewise help to diminish aggravation and odds of disease. It is now quite clear that pre & probiotics are not only important for maintaining the gut health but also maintain healthy overall internal organs and strengthen
immunity.
Chloride binding in concrete: recent investigations and recognised knowledge gaps: RILEM Robert L’Hermite Medal Paper 2021
Authors: De Weerdt Klaartje
Published: November 2021

A theoretical understanding of chloride binding is urgently needed if we are to use the new low-CO2composite cements in reinforced concrete structures exposed to chloride-loaded environments. The empirical models and “deemed-to-satisfy” rules currently in use will not help in the face of the wide variety of new SCMs now being proposed. Engineers need generic chloride ingress models that can handle the variations in binder chemistry and exposure conditions. This paper reviews a selection of recent investigations by a team of NTNU researchers and international collaborators on various Portland composite cements using a combination of equilibrium chloride-binding experiments and thermodynamic modelling. One of our main findings is that “leaching” simulated by varying the pH and the calcium concentration has a dominant effect on chloride binding. However, challenges regarding the quantification and characterization of the chloride binding phases have yet to be overcome. To advance in this field we need additional crucial thermodynamic data for chloride-binding hydrates formed by low-CO2cements containing SCMs, and we need to overcome some experimental challenges. A major break-through would come from understanding the interactions between chlorides and C(-A)-S-H. Part of the answer might be found at the atomic level. Finally, mechanistic numerical models are needed to upscale the findings from chloride binding to chloride ingress models. We conclude by showing the significance of such theoretical work on chloride binding for engineers tasked with the construction and maintenance of the reinforced concrete structures that are so vital a part of modern infrastructure.
Effective Health Services Planning and Delivery: A Qualitative Case Study Exploring Health Services Users’ Perspectives
Authors: G Marme
Published: November 2021

Introduction: Healthcare service is an essential determinant of population health. This qualitative case study aims to explore health service users’ perspectives of effective health services delivery and the current challenges affecting the management and delivery of health services at a primary healthcare facility in Madang Province, Papua New Guinea (PNG).
Caregiving for children and parental labor force participation during the pandemic
Authors: Montes Joshua , Smith Christopher , Leigh Isabel
Published: November 2021

The labor force participation rate (LFPR)—the fraction of the population ages 16 and older that is either working or actively looking for work—moved up steadily over the last few years prior to the COVID-19 pandemic and stood at 63.3 percent in February 2020. Two months later, the LFPR had plunged to 60.2 percent, and despite some improvement since then, the LFPR has remained depressed relative to its pre-COVID level (fluctuating between 61.4 percent and 61.7 percent since Fall 2020).
Well-being and the Perception of Stress among EFL University Teachers in Saudi Arabia
Authors: Alqarni Nada A.
Published: November 2021

Research on language teachers’ psychology has been shown to play a central role in the quality of teaching and student achievement. However, there is little empirical evidence to investigate the relationship between perception of stress, types of stressors, and well-being among foreign language teachers at university levels, particularly in monolingual contexts. The present study seeks to investigate the impact of stress, the number and type of stressors (i.e., chronic and stressful life events), and demographic variables (i.e., age, gender, and the length of teaching experience) on university-level EFL teachers’ levels of well-being. The data were collected through an online survey of 53 university-level EFL teachers in Saudi Arabia. A Pearson correlation was carried out to investigate the relationship between EFL teachers’ well-being, their perception of stress, and number of stressors. A multiple regression analysis was also run to examine if EFL teachers’ levels of stress, number and types of stressors, and demographic variables can predict their psychological well-being. The quantitative findings demonstrated a significant negative relationship between well-being and levels of stress. The findings also showed a significant positive relationship between the EFL teachers’ well-being and their good physical health. The results of the multiple regression indicated that high levels of well-being were predicted by low levels of stress and good physical health. This study, moreover, suggested an advantage for females in terms of psychological well-being among foreign language teachers. The findings also demonstrated that a stressful life with a heavy workload and financial concerns can negatively impact language teachers’ well-being. These findings highlight the importance of considering issues related to teachers’ psychological well-being. In line with these findings, several pedagogical implications were offered.
Investigating the Experience of Boredom During Reading Sessions in the Foreign Language Classroom
Authors: Kruk Mariusz
Published: November 2021

Despite the fact that boredom appears to be one of the most commonly experienced emotions in school settings, this negative emotion remains vastly underappreciated in the field of SLA. This is the gap this article seeks to rectify by reporting the findings of a classroom-based study whose purpose was to investigate changes in the experience of boredom in an English language classroom during reading sessions. The sample consisted of 18 second-year students studying English at a Polish high school. The data were collected by means of session logs, observations and reading session plans. The gathered data were analysed quantitatively and qualitatively. The findings showed that the participants reported different levels of boredom over the course of single reading sessions and from one session to the next. Factors responsible for the detected variation in the levels of boredom were related, among other things, to inactivity, performance of too easy/difficult tasks, teacher’s decisions regarding choice and use of language materials, the design of the reading sessions or individual characteristics of the learner.
Directed Motivational Currents (DMCs) in Self-directed Language Learning: An Interpretative Phenomenological Analysis
Authors: Xodabande Ismail , Babaii Esmat
Published: November 2021

Directed Motivational Currents (DMCs) postulated as a novel motivational construct in second language acquisition (SLA) research to explain periods of intense and enduring behavior in pursuit of a highly valued goal or vision. Nonetheless, much of the discussion related to this new motivational phenomenon has remained theoretical, and only a limited number of empirical studies have investigated its various dimensions in language learning. The current qualitative study employed interpretative phenomenological analysis (IPA) to explore a period of intense motivation experienced by an Iranian language learner in self-directed and mobile assisted language learning. The findings provided further empirical evidence for the triggering stimulus and the core characteristics of DMCs in terms of goal/vision orientedness, a salient facilitative structure, and positive emotionality in explaining the essence and the universal meaning of the phenomenon experienced by the participant of the current study.
Monitoring of Vegetation Cover Changes With Geomorphological Forms using Google Earth Engine in Kendari City
Authors: Aldiansyah Septianto , Mandini Mannesa Masita Dwi , Supriatna Supriatna
Published: November 2021

Vegetation cover plays an important role in controlling the view, boundaries, air temperature, living place and aesthetics in an area. Vegetation cover changes can be caused by changes in temperature, rainfall and human activities. Google Earth Engine (GEE) provides machine learning algorithms such as NDVI which are very useful in extracting vegetation density levels from imagery. The purpose of this study was to analyze vegetation cover changes by human activities in relation to the geomorphological form of Kendari City. The imagery used in multi-temporal monitoring are Landsat-7 ETM in 2000, Landsat-5 TM in 2005 and 2010 and Landsat 8 OLI in 2015 and 2020. Input machine learning using near infrared (NIR) and red (Red) for the NDVI Algorithm while the geomorphological form uses SRTM imagery. The classification of vegetation cover consists of water bodies, open field, built areas and roads covered with asphalt, paving or soil, plantations/agriculture, bushes, grass, reeds, green open space and forests. Each sub-district experienced a decrease in vegetation cover in the form of plantations/agriculture, bushes, grass, reeds, green open space except for the West Kendari District which tended to be varied. The forest area is getting better every year. The existence of protected forests and geomorphological forms such as lowlands are the driving factors for changes in vegetation cover, while low hills and high hills are flat to steep are contrainst factors. Machine learning in GEE is very helpful in monitoring vegetation cover changes and has an NDVI algorithm that is quite easy to apply.
Proses Kampanye Public Relations “Youtube Broadcast Box” Di Media Sosial
Authors: Natashya Merina Lydia Isabella , Hafiar Hanny , Nugraha Aat Ruchiat
Published: November 2021

ABSTRAK Perkembangan strategi brand suatu produk sekarang ini semakin kreatif dengan menggunakan berbagai media komunikasi untuk dapat mempersuasi publik. Keberadaan suatu brand dapat dikomunikasikan melalui pendekatan emotional feel, attitude change, dan behaviour yang dilakukan terhadap target sasarannya. Youtube sebagai provider yang memiliki peran yang kuat dalam menyimpan data informasi yang paling besar berupa tayangan film dapat memberikan kontribusi untuk membangun dan meningkatkan brand experience produk tertentu. Tujuan penelitian ini adalah untuk mengetahui proses kampanye yang dilakukan oleh Youtube Broadcast Box dalam upaya meningkatkan brand experience terhadap Youtubers Indonesia. Adapun metode penelitian yang digunakan adalah deskriptif dengan teknik pengumpulan data melalui wawancara terstruktur, observasi, dan studi pustaka. Dalam teknik penentuan key informan, penelitian ini menggunakan teknik purposive sampling. Hasil penelitian menunjukkan bahwa proses kampanye public relations yang dilakukan oleh Youtube Broadcast Box telah dapat meningkatkan brand experience para Youtubers Indonesia yang dibuktikan dengan banyaknya kunjungan dari audience yang ingin menonton tayangan di Youtube secara berkelanjutan untuk berbagai kegiatan yang dianggap memiliki nilai informasi bagi publik. Kata Kunci : Kampanye Public Relations, Brand Experience, dan Youtube Broadcast Box ABSTRACT The development of the brand strategy a product now this is getting creative by the use of various media of public communication persuasive. The existence of a brand can be communicated with the emotional feel , attitude change , and behaviour was done with their targets. Youtube as providers having role strong in store data information the greatest of impressions film to give contribution to build and improve brand experience certain products. The purpose of this research is to aware of the campaign done by youtube broadcast box in order to increase brand experience of youtubers Indonesia. As for research methodology used is descriptive to technique data collection through interviews structured, observation, and the literature study. The technique of the determination of key informants, this research using a technique purposive sampling. The research results show that the process of public relations campaign conducted by broadcast box of youtube has been able to increase brand experience the youtubers indonesia which is evidenced by the number of visits from audience who want to watch impressions on youtube in a sustainable way for various activities being regarded as having the value of information to the public. Keywords: public relations campaign, brand experience, and youtube broadcast box
Implementasi Program Parenting Dalam Membangun Komunikasi Pengasuhan Anak Usia Dini (Penelitian Best Practice di TK Al-Jannah Kota Bandung)
Authors: Setiani Ani
Published: November 2021

Abstrak Pendidikan anak usia dini (PAUD), pada hakekatnya adalah pendidikan yang diselenggarakan dengan tujuan untuk memfasilitasi pertumbuhan dan perkembangan anak. Salah satu faktor penting penyelenggaraan PAUD adalah komunikasi yang efektif dan efisien antara pihak sekolah dengan orang tua. Program parenting di TK Al-Jannah selama Tahun pelajaran 2018/2019 terlaksana secara keseluruhan sesuai program yang direncanakan. Namun dampak dari kegiatan tersebut belum diteliti secara obyektif. Oleh karena itu, dilakukan penelitian yang bertujuan untuk mengetahui sejauh mana dampak program parenting di TK Al-Jannah terhadap pola asuh orang tua di rumah. Jenis penelitian yang disajikan adalah “Best Practice”. Metode penelitian yang digunakan adalah metode penelitian kualitatif dengan tehnik pengumpulan data melalui studi dokumentasi, wawancara, dan observasi. Setelah dilakukan kajian dari berbagai unsur terlihat kecenderungan hasil akhir bahwa dengan Program Parenting yang telah dijalankan oleh TK AL Jannah melalui komunikasi yang efektif dilakukan baik oleh Kepala TK, pendidik dan orang tua, dapat meningkatkan kesamaan pemahaman orang tua dalam memberikan pola asuh yang baik kepada para putera puterinya hingga 90%, capaian indicator 6 aspek pengembangan mencapai hasil 80% hingga 100%.Kata Kunci : Parenting; Komunikasi; Pengasuhan; PAUDAbstractEarly childhood education (PAUD), in essence is education that is organized with the aim of facilitating children's growth and development. One important factor in the implementation of PAUD is effective and efficient communication between the school and parents. The parenting program at Al-Jannah Kindergarten during 2018/2019 was carried out as a whole according to the planned program. But the impact of these activities has not been studied objectively. Therefore, a study was conducted aimed at finding out the extent of the impact of the parenting program at Al-Jannah Kindergarten on parenting at home. The type of research presented is "Best Practice". The research method used is a qualitative research method with data collection techniques through the study of documentation, interviews, and observations. After a study of various elements shows the tendency of the final results that with the Parenting Program that has been run by TK AL Jannah through effective communication conducted both by the Head of Kindergarten, educators and parents, can increase the common understanding of parents in providing good parenting to the sons and daughters up to 90%, achievement indicators 6 aspects of development achieved 80% to 100% results.Keywords: Parenting; Communication; Nurturing; PAUD
Tiga Dekade Perkembangan Integrated Marketing Communications (IMC): Sebuah Literatur Review
Authors: Estaswara Helpris
Published: November 2021

Abstrak Sejak kelahirannya, tiga dekade yang lalu hingga hari ini, IMC (Integrated Marketing Communications) telah menjadi perhatian para akademisi dan praktisi di seluruh dunia. Sebagai kajian yang relatif baru, penting untuk meninjau perkembangan IMC yang ditelusuri dari berbagai tulisan yang diterbitkan di jurnal-jurnal internasional terindeks sebagai bentuk manifestasi perkembangannya. Guna melihat perkembangan IMC selama tiga dekade ini dapat didasarkan pada tiga aspek, yaitu theoretical building, topik penelitian dan pengimplementasian IMC. Tujuannya untuk: (1) Melihat sejauhmana perkembangan IMC jika dilihat dari ketiga aspek tersebut dengan membandingkan deskripsi perkembangan sebelum tahun 2005? (2) Aspek apa yang berkembang paling signifikan sehingga beda dengan gambaran perkembangan IMC sebelum tahun 2008? Tahun 2005 dan 2008 dijadikan patokan karena pada saat itu riset perkembangan IMC secara teoretis (2005) dan topik-topik penelitian serta implementasinya (2008) telah dipublikasikan. Dengan menggunakan kajian literatur, penelitian ini menyimpulkan bahwa IMC terus berkembang secara teoretis, namun demikian tidak meninggalkan gagasan dasar yang telah dibangun pada tahun 2005. Hingga kini, teorisasi IMC semakin memertajam bangunan kontruksnya dan lebih bersifat multi-disipliner. Kata Kunci: Perkembangan IMC, Teorisasi IMC, Topik penelitian, Implementasi IMC Abstract Since its inception, three decades ago until today, IMC (Integrated Marketing Communications) has become attention of academics and practitioners around the world. As a relatively new concept, it is important to review the development of IMC which is traced from various papers published in international journals indexed as a manifestation of its development. To identify the development of IMC over the past three decades, it can be based on three aspects, namely theoretical building, research topics, and IMC implementation. Aim of this article is to: (1) Describe IMC development that is viewed from three aspects by comparing before 2005? (2) What aspect is developed most significantly so that it is different from the description of IMC development before 2008? Year 2005 and 2008 were used as benchmarks because at that time research on development of IMC theoretical (2005), research topics, and its implementation (2008) had been published. Using literature review, this research concludes that the IMC continues to develop theoretically, but did not abandon the basic ideas that had been built in 2005. Hitherto, theorization of IMC has sharpened in its construct and become more multi-disciplinary in nature. Keywords: IMC development, IMC theorization, research topics, IMC implementation,
PENERAPAN TERAPI KELOMPOK TERAPEUTIK DAN TERAPI ASERTIF UNTUK PENCEGAHAN PERUNDUNGAN PADA ANAK USIA SEKOLAH DENGAN PENDEKATAN KOMUNIKASI INTERPERSONAL PEPLAU
Authors: Rahayu Aty Nurillawaty , Susanti Herni , Daulima Novy H.C
Published: November 2021

ABSTRAK. Tahap perkembangan anak usia sekolah jika tidak tercapai akan menimbulkan perilaku yang menyimpang. Tulisan ini bertujuan melaporkan pengaruh Terapi Kelompok Terapeutik (TKT) dan Terapi Asertif terhadap perkembangan dan kemampuan perilaku asertif anak sekolah dalam mencegah perundungan (bullying) dengan pendekatan model hubungan interpersonal Peplau di Kota Bogor Jawa Barat, Indonesia. Pemberian terapi-terapi ini dilakukan pada dua anak usia sekolah yang dilakukan di masyarakat dalam program Community Mental Health nursing (CMHN). Pemberian TKT terbukti mampu meningkatkan kemampuan anak secara motorik, kognitif, bahasa, moral, spiritual, emosi, kepribadian dan psikososial sedangkan penambahan terapi asertif setelah TKT dapat lebih meningkatkan kemampuan aspek bahasa, emosi dan kemampuan perilaku asertif anak Keluarga dan kader sehat jiwa membantu memudahkan penulis dalam melakukan tindakan keperawatan. Hasil penerapan terapi ini merekomendasikan agar perawat spesialis keperawatan jiwa saat deteksi dini pada anak usia sekolah menggunakan pengkajian perkembangan dan assesment perundungan (bullying), serta bekerjasama dengan perawat CMHN, keluarga dan kader kesehatan jiwa dalam menerapkan TKT dan terapi asertif. Serta Terapi ini juga bisa diterapkan di sekolah dalam program Usaha Kesehatan Jiwa di Sekolah untuk mencegah perundungan (bullying) pada anak. Kata kunci : Anak sekolah; tumbuh kembanng; terapi kelompok terapeutik’ assertiveness training ; Hubungan Interpersonal Peplau
Penerapan Project Based Learning Menggunakan Microblogging Edmodo untuk Meningkatkan Prestasi Belajar Siswa Pada Pembelajaran Matematika
Authors: Saepulloh Saepulloh , Nurhayati Fitri , Darmawan Iwan
Published: November 2021

Abstract The purpose of this study was to determine the effectiveness of using a project-based learning model using Edmodo microblogging in improving student achievement in mathematics learning. This study uses a quantitative approach with a quasi-experimental method. The results showed that the increase in student achievement by using project-based learning using Edmodo in the experimental class was higher than the conventional method in the control class. Student responses amounted to 87.23%. shows that students give a very good/positive response to project-based learning using Edmodo microblogging. Keywords: Edmodo;Project-Based Learning;Student Learning Achievement AbstrakTujuan penelitian ini adalah untuk mengetahui efektivitas penggunaan model pembelajaran project based learning dengan menggunakan microblogging edmudo dalam meningkatkan prestasi belajar siswa pada pembelajaran matematika. Penelitian ini menggunakan pendekatan kuantitatif dengan metode kuasi eksperimen. Hasil penelitian menunjukan peningkatan prestasi belajar siswa dengan menggunakan project based learning menggunakan edmudo pada kelas eksperimen lebih tinggi dibandingkan dengan metode konvensional pada kelas control. Tanggapan siswa sebesar 87.23%. menunjukan bahwa siswa memberikan  respon yang sangat baik/positif terhadap project based learning menggunakan microblogging edmudo. Kata Kunci: Edmudo;Prestasi Belajar Siswa;Project Based Learning
Optimalisasi TIK Dengan Memanfaatkan Whatsapp Dalam Pembelajaran Fisika Dimasa Pandemi Covid-19
Authors: Nurazizah Erika , Nuraeni Yeti , Wahyudin Wahyudin
Published: November 2021

Optimalisasi TIK pada pembelajaran jarak jauh harus dilakukan selama pandemi covid-19. Salah satunya dengan memanfaatkan aplikasi Whatsapp (WA) pada pembelajaran fisika. Dilakukan penelitian menggunakan metode kualitatif deskriptif dan pengumpulan data menggunakan angket, observasi dan wawancara pada 30 responden yang merupakan murid kelas XI IPA SMA IT ANNISA Kadungora. Responden mengisi data melalui chating dan tautan yang dikirimkan pada chating grup WA. Hasilnya menunjukkan 40% merasa sangat terbantu, 53% terbantu dan 7% cukup terbantu dalam komunikasi pembelajaran. Kemudian 7% merasa sangat terbantu, 86 % terbantu dan 7% cukup terbantu dalam penyampaian bahan pembelajaran. Data yang diterima ini tidak mengurangi nilai yang didapatkan dibandingkan dengan tatap muka langsung. Bahkan mampu meningkatkan motivasi belajar dan memudahkan pembelajaran dengan adanya interaksi, peningkatan kualitas komunikasi dan diskusi. Responden sangat antusias dan menyarankan agar mengaplikasikannya pada pembelajaran lain. Diharapkan pada tahap selanjutnya dengan melakukan penelitian lanjutan untuk mengetahui pengaruh pemanfaatan WA dari segi prestasi.
Replacement of common urea with protected urea in sheep supplement
Authors: Ribeiro P. R. , Schultz E. B. , Sousa L. F. , Macedo Júnior G. L.
Published: November 2021

The objective was to evaluate the effect of replacing common urea with protected urea in the supplement on the nutrient intake and digestibility and metabolic profile of sheep. Five adult sheep, with an average age of 4 years and an initial average body weight of 50 ± 4.03 kg, were used. The diet consisted of sorghum silage, supplemented with a multiple mixture of corn bran, soybean meal, white salt, mineral salt, common urea (CU) or protected urea (PU). The experimental design was a 5x5 Latin square. Treatments consisted of: control or 100% CU, 75% CU and 25% PU, 50% CU and 50% PU, 25% CU and 75% PU and 100% PU. Collections and analysis of feed, feces, urine and blood were carried out to assess intake, digestibility and blood metabolites. Analysis of variance and SNK test were applied considering 5% significance. Nonparametric data were analyzed by Kruskal-Wallis at a significance level of 5%. The replacement of common urea with protected urea did not (P> 0.05) alter the intake of dry matter, crude protein and water, and the dry matter digestibility. The production of urine and feces, and the density of urine also did not (P> 0.05) show statistical difference with the replacement of common urea with protected urea. As for protein and energy metabolites, only glycemia showed variation (P <0.05), with the proportion of 75% CU and 25% PU, indicating the highest concentration of glucose in relation to the replacement of 0, 50 and 100% PU in the supplement. There are no benefits from partial or total replacement of common urea with protected urea in sheep supplementation.
Review of the article "Long-term oncological and functional results of robot-assisted radical prostatectomy"
Authors: Zyryanov A. V.
Published: November 2021

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Oncocytic adrenocortic tumor of the adrenal (clinical case)
Authors: Gebenov M. Kh. , Akhokhov Z. M.
Published: November 2021

A clinical case of treatment of a 32-year-old patient with an adrenocortical tumor of the right adrenal gland is described. When applying to the clinic, the patient was complaining about moderate pain in the right lumbar region, the general condition of the patient was estimated as satisfactory. The patient was of normosthenic constitution, had no bad habits, preoperative general and biochemical blood counts, including the levels of adrenocorticotropic hormone, cortisol, aldosterone, direct renin, metanephrine, normetanephrine were within normal parameters. The patient underwent laparoscopic lateral transperitoneal adrenalectomy on the right in the position on the left side using 4 trocars. The condition of the patient was satisfactory, he was released from the hospital on the 3rd day after surgery.
Review of the article "First experience of superselective embolization of renal arteries supplying the tumor with subsequent laparoscopic kidney resection"
Authors: Perlin D. V.
Published: November 2021

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Germinal BRCA-mutation significance in the tumor microenvironment formation Efficacy of PARP inhibition in late-line therapy of metastatic castration-resistant prostate cancer
Authors: Stukan A. I. , Goryainova A. Yu. , Riger N. A. , Sharov S. V. , Shatokhina A. S. , Chukhray O. Yu. , Andreev D. V.
Published: November 2021

Metastatic castration-resistant prostate cancer is a difficult problem for a clinical oncologist. In addition, mutations in genes of homologous DNA recombination, including BRCA1/2, suggest an aggressive behavior and therapy resistance. Treatment options for such patients were significantly limited until new drugs - PARP inhibitors have been registered. Nevertheless, there is evidence that BRCA1/2 gene mutations are associated with increased mutational load, neoepitopes formation, increased number of tumor-infiltrating lymphocytes and a response to the immune response checkpoints blockade. Studies have shown that BRCA2-mutated prostate cancer demonstrates high level of immune cells infiltration compared to tumors without mutation, in particular with respect to CD4+, CD8+ and FOXP3+ T-lymphocytes. It should be noted that studies have shown a tendency of CD8+ T-lymphocytes/FOXP3+ T-cells ratio decreasing in BRCA2-mutated tumors. Thus, the mutational status of BRCA2 presumably forms the immune phenotype of prostate cancer with an increase of intratumoral immune cells, but with immunosuppressive properties. At the same time, the use of immune checkpoint blockers in advanced prostate cancer has been unsuccessful in terms of overall survival. Despite the fact that immune checkpoint blocker's efficacy is often associated with a high intracellular CD4+ and CD8+ T lymphocytes, their presence is clearly insufficient for response. Studies showed that PARP inhibitors effect tumor microenvironment significantly. Anti-PD-1/PD-L1 combination with PARP inhibitors is being actively studied due to their properties of modulating the tumor microenvironment. Thus, future immunooncological strategies for primary prostate cancer therapy may include not only an increase in mutational load, but also an impact on the immunosuppressive microenvironment. The article presents clinical cases of 3 brothers, carriers of the germinal BRCA2 c.9371A>T mutation, suffering from prostate cancer with a burdened family history. The disease development under standard therapies was studied and markers of the tumor microenvironment were immunohistochemically evaluated. PARP inhibitor Olaparib efficacy in prostate cancer of older brother in late-line therapy for metastatic castration-resistant disease was analyzed.
Immunocorrective treatment use in the prevention of hematological and infectious complications of chemotherapy in cancer patients
Authors: Grivtsova L. Yu. , Larionova V. B. , Falaleeva N. A.
Published: November 2021

The article analyzes the use of immunocorrection of hematological toxicity that occurs during chemotherapy in cancer patients. Hematological toxicity, along with cardiotoxicity and hepatotoxicity often prevents the implementation of the entire planned volume of chemotherapy.

Standard therapy (colony stimulating factor use) may not be always available and there is a need to develop new and more effective strategies for supportive care. Among the various methods and approaches, the most promising may be the use of systemic immunecorrecting therapy, the possibilities of which are far from being realized in oncological practice.

The analysis of the studies summarized in this review demonstrates the effectiveness of the immunomodulator/immu‑ noadjuvant – azoximer bromide in hematological toxicity prevention in patients with various types of cancer.
Molecular serological characteristics of ABO system A antigen
Authors: Golovkina L. L. , Kalandarov R. S. , Pshenichnikova O. S. , Surin V. L. , Stremoukhova A. G. , Pushkina T. D. , Atroshchenko G. V. , Kalmykova O. S. , Khasigova B. B.
Published: November 2021

Background. One of the polymorphic antigens in the ABO system is antigen A, which includes many allelic variants with different expression. Immunological methods for determining the blood group of the ABO system have limitations in their use, including due to the presence of weekly expressed antigens in humans. For the correct determination of blood group according to the ABO system, genetic typing is becoming increasingly important. 89 alleles of the ABO*A gene are known. Knowledge of ABO*A gene polymorphisms and their prevalence contributes to the prevention of errors in determining the blood group of donors and recipients.

Objective: to describe variants of ABO*A gene alleles in Russians and serological characteristics of the antigens encoded by them.

Materials and methods. The blood of 14,000 people was examined. The blood group was determined using anti-A, anti- Aweak, anti-B, lectin (anti-A1) and gel cards. A molecular study of ABO*A gene polymorphisms was conducted in 151 people. Polymerase chain reaction with sequence-specific primers and direct Sanger sequencing were used.

Results. 7 different ABO*A alleles were detected, including the ABO*A1.01 and ABO*A1.02 alleles. In 118 individuals with a weak A antigen, the ABO*A2.01 allele was the most frequent (87.29 %). Rare alleles ABO*A2.06 (5.93 %), ABO*AW.06 (4.23 %), ABO*A2.09 (0.85 %) and ABO*Ax (1.70 %) were found. Serological characteristics of A antigens variants depending on genotypes are described, variants A1, A2, A3 and very weak A were detected. Extraagglutinins α1 were absent in all persons with weakened A antigen.

Conclusion. Small or mixed agglutination with Coliclones or red blood cell stratification in the gel suggest the presence of antigen A with weakened expression. Modern molecular methods make it possible to identify rare gene alleles and genotypes. Erythrocyte genomics helps to resolve the ambiguity of the serological results allows understanding the true mechanisms of particular phenotype formation and makes a contribution to ensuring the immunological safety of blood components transfusions.
New Magnitude Proxy for Earthquake Early Warning Based on Initial Time Series and Frequency
Authors: Wang Yanwei , Li Xiaojun , Li Li , Wang Zifa , Lan Jingyan
Published: November 2021

A new characteristic parameter Sdτ is proposed to improve the performance of magnitude estimation in earthquake early warning (EEW). Sdτ is the product of summation of absolute displacement multiplied by the maximum predominant period (τmaxP) for the first arriving seconds of a seismic wave. About 30,725 underground records at borehole stations for 3645 earthquakes with magnitude between 4.0 and 9.0 from the Japanese KiK-net were used to compare the magnitude proxy performance based on the proposed Sdτ with that based on either τmaxP or peak displacement Pd. The comparison results show that for a magnitude between 4.0 and 7.3, Sdτ has a better correlation with magnitude and higher estimated accuracy than either τmaxP or Pd. Hypocentral distance is not required when using Sdτ, but it can be used to further improve the accuracy of magnitude estimate. These results confirm that Sdτ can significantly improve the accuracy and timeliness of continuous magnitude estimation in an EEW system.
Calculation of the impedance characteristics of a microstrip loop antenna with a metallized dielectric substrate
Authors: Korshunov S.A.
Published: November 2021

In connection with the intensive development of electronic technology, an urgent task is the development of antennas in a microstrip way, the advantages of which are small dimensions, a relatively simple manufacturing technology, and the ability to control their characteristics by using various materials and forms of radiators in their design. Currently, there are many mathematical models of microstrip antennas with vibrator radiators located on dielectric substrates, while models of microstrip antennas with other radiator shapes are presented much less often. As a rule, the calculation of the characteristics of such antennas is performed in electrodynamic modeling systems based on the use of «closed» algorithms. In this regard, there is a need to develop rigorous mathematical models of microstrip antennas with radiators of various shapes. This work is dedicated to the development of a rigorous model of a microstrip antenna with a frame radiator located on a dielectric substrate, based on the use of the method of integral equations. An integral equation is obtained for the unknown distribution function of the radial component of the current density over a frame radiator, the numerical solution of which is a correct mathematical problem. In addition, the numerical results of calculating the current density distribution, as well as the input impedance of such an antenna for various parameters of the radiator and substrate, are presented.
Method for determining the two-dimensional current density distribution function over the radiating structure based on chiral metamaterials
Authors: Neshcheret A.M.
Published: November 2021

The article is devoted to the development of a method of electrodynamic analysis and a two-dimensional mathematical model of strip radiating structures based on the apparatus of hypersingular equations in order to ensure the correct calculation of their characteristics when using relatively small computational resources. A system of hypersingular integral equations with respect to the unknown transverse and longitudinal components of the current density distribution functions is obtained. This system of hypersingular equations was solved using the collocation method, where Gaussian nodes (zeros of Legendre polynomials) were used as collocation points. This approach allows for faster convergence compared to uniform partitioning. Numerical results of calculations of current density distribution functions for various parameters of the radiating structure based on chiral metamaterials are obtained. It is shown that in the case of wide emitters, it is necessary to take into account both components of the current density distribution function. The advantage of this method in comparison with universal analogues is the ability to accurately calculate the characteristics of radiating structures based on chiral metamaterials with wide emitters.