bluuebunny/crossref_metadata_2025 huggingface dataset:
Barriers and Challenges Going from Conventional to Cryogenic Superconducting Propulsion for Hybrid and All-Electric Aircrafts
Authors: da Silva Francisco Ferreira , Fernandes João F. P. , da Costa Branco Paulo Jose
Published: October 2021

The development of electric aircraft is becoming an important technology for achieving the goals set by the European Commission for the reduction of gases emissions by 2050 in the aeronautical transportation system. However, there is a technology gap between the current values of specific power in commercial electric machines and those required for aeronautical applications. Therefore, the search for alternative materials and non-conventional designs is mandatory. One emergent solution is using superconducting machines and systems to overcome the current limits of conventional electrical machines. This work reviews the new hybrid and all-electric aircraft tendencies, complementing it with recent research on the design and development of high specific power superconducting machines. This includes the main topologies for hybrid and all-electric aircraft, with an overview of the ongoing worldwide projects of these aircraft types, systematizing the main characteristics of their propulsion systems. It also includes the research on superconducting machines to achieve high specific power and consider the impact on the redesign of aircraft systems, the electrical, cooling, and fuel source systems.
Differentiation of the Generation Potential of the Menilite and Istebna Beds of the Silesian Unit in the Carpathians Based on Compiled Pyrolytic Studies
Authors: Matyasik Irena , Labus Małgorzata , Kierat Maria , Spunda Karol
Published: October 2021

The study of the source rocks was carried out with the use of various analytical methods in order to assess their generation potential and to predict the decomposition products of organic matter. The selected samples from the Menilite Beds from the Silesian and Dukla units, as well as the Istebna layers from the Silesian unit, which are classified as weak and medium source rocks in the Carpathian oil system, were examined. The generation potential and type of the products obtained from the pyrolysis of the analyzed source rocks, despite the often comparable overall content of organic matter, are significantly different. Menilite shale generated a higher abundance of hydrocarbons (alkanes, alkenes, and isoalkanes) by stage pyrolysis, which suggested that the organic matter of Menilite shale is different from the Istebna source rocks. Moreover, the thermogravimetric analysis showed a two-stage weight loss in the case of Menilite shales, while the Istebna shales were characterized by a one-stage weight loss at higher temperature. For the Istebna layers, n-alkanes from the C1–C5 range were detected as the main pyrolysis products, which proves the gas-forming type of the organic matter dispersed in these sediments. Rock-Eval analyses showed that the organic matter reached a degree of maturity corresponding to the early thermocatalytic processes (the initial oil window stage) and therefore was able to generate liquid and gaseous hydrocarbons. The comparison of the decomposition temperatures of the organic matter from the Rock-Eval and TG analyses allowed us to conclude that both measurements correlate well and can be equally used to assess the level of thermal transformations of organic matter.
A Bibliometric Review of Sustainable Product Design
Authors: Jiang Pingfei , Dieckmann Elena , Han Ji , Childs Peter R. N.
Published: October 2021

Consideration of sustainability in product development is becoming increasingly important and encompasses many aspects of product design. In this study, a bibliometric review of recent sustainable product design publications using Web of Science and VOSViewer is carried out. The review indicates that the majority of publications concerning sustainable product design is oriented towards environmental science-led subject areas and production-led journals. Analysis of author keyword co-occurrences reveals that circular economy, life cycle assessment, sustainable management, and optimization are the most popular topics in sustainable product design research. The analysis also reveals that the researchers fail to link sustainability research to activities in product design, which leads to the lack of access to relevant research that can make products more sustainable. Building on the findings, the authors propose four future research directions that aim to guide researchers to better correlate sustainability with product design, namely: sustainability interpretation, integration, assessment and validation, and improvement.
Transcriptome Profiling of Maize (Zea mays L.) Leaves Reveals Key Cold-Responsive Genes, Transcription Factors, and Metabolic Pathways Regulating Cold Stress Tolerance at the Seedling Stage
Authors: Waititu Joram Kiriga , Cai Quan , Sun Ying , Sun Yinglu , Li Congcong , Zhang Chunyi , Liu Jun , Wang Huan
Published: October 2021

Cold tolerance is a complex trait that requires a critical perspective to understand its underpinning mechanism. To unravel the molecular framework underlying maize (Zea mays L.) cold stress tolerance, we conducted a comparative transcriptome profiling of 24 cold-tolerant and 22 cold-sensitive inbred lines affected by cold stress at the seedling stage. Using the RNA-seq method, we identified 2237 differentially expressed genes (DEGs), namely 1656 and 581 annotated and unannotated DEGs, respectively. Further analysis of the 1656 annotated DEGs mined out two critical sets of cold-responsive DEGs, namely 779 and 877 DEGs, which were significantly enhanced in the tolerant and sensitive lines, respectively. Functional analysis of the 1656 DEGs highlighted the enrichment of signaling, carotenoid, lipid metabolism, transcription factors (TFs), peroxisome, and amino acid metabolism. A total of 147 TFs belonging to 32 families, including MYB, ERF, NAC, WRKY, bHLH, MIKC MADS, and C2H2, were strongly altered by cold stress. Moreover, the tolerant lines’ 779 enhanced DEGs were predominantly associated with carotenoid, ABC transporter, glutathione, lipid metabolism, and amino acid metabolism. In comparison, the cold-sensitive lines’ 877 enhanced DEGs were significantly enriched for MAPK signaling, peroxisome, ribosome, and carbon metabolism pathways. The biggest proportion of the unannotated DEGs was implicated in the roles of long non-coding RNAs (lncRNAs). Taken together, this study provides valuable insights that offer a deeper understanding of the molecular mechanisms underlying maize response to cold stress at the seedling stage, thus opening up possibilities for a breeding program of maize tolerance to cold stress.
Single-Cell RNA-Seq Revealed the Gene Expression Pattern during the In Vitro Maturation of Donkey Oocytes
Authors: Li Zhipeng , Song Xinhui , Yin Shan , Yan Jiageng , Lv Peiru , Shan Huiquan , Cui Kuiqing , Liu Hongbo , Liu Qingyou
Published: October 2021

Donkeys are an important domesticated animal, providing labor, meat, milk, and medicinal materials for humans. However, the donkey population is continuously declining and even at risk of extinction. The application of modern animal production technology, such as oocyte in vitro maturation, is a promising method to improve the donkey population. In this study, we explore the gene expression patterns of donkey germinal vesicle (GV) and in vitro matured metaphase II (MII) oocytes using single cell RNA-seq of the candidate genes along with the regulatory mechanisms that affect donkey oocyte maturation. We identified a total of 24,164 oocyte genes of which 9073 were significant differentially expressed in the GV and MII oocytes. Further Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that these genes were associated with the meiotic cell cycle, mitochondrion activity, and N-glycan biosynthesis, which might be the key genes and regulatory mechanisms affecting the maturation of donkey oocytes. Our study provides considerable understanding regarding the maturation of donkey oocytes and serves as a theoretical basis for improving the development of donkey oocytes, which could ultimately benefit the expansion of the donkey population and conservation of biodiversity and genetic resources.
Major Hepatectomy En Bloc with Cava Vein Resection for Locally Invasive Caudate Lobe Hepatocarcinoma
Authors: Bacalbasa Nicolae , Balescu Irina , Ichim Florin , Barbu Ion , Ristea Alexandru , Lazea Razvan , Danciuc Ioana , Popa Ioana , Magdoiu Ovidiu , Smira Gabriela , Diaconu Camelia , Furtunescu Florentina , Stiru Ovidiu , Savu Cornel , Stoica Claudia , Brasoveanu Vladislav , Ursut Bogdan , Al Aloul Adnan
Published: October 2021

Background/Aim: Locally advanced liver tumours with vascular invasion have been considered for a long period of time as unresectable lesions, so the patient was further deferred to oncology services for palliation. However, improvement of the surgical techniques and the results reported so far came to demonstrate that extended hepatic and vascular resections might be safely performed in such cases and might significantly improve the long-term outcomes. Materials and Methods: A 61-year-old patient was diagnosed with a caudate lobe tumour invading the inferior cava vein and the right hepatic pedicle. Results: The patient was successfully submitted to surgery, and an extended right hepatectomy en bloc with cava vein resection was performed; the continuity of the cava vein was re-established by the placement of a synthetic graft. The postoperative outcome was uneventful. Conclusions: Although initially considered as a formal contraindication for resection, vascular invasion of the greater vessels should not preclude surgery if complete resection is achievable.
An Empirical Study on Hazardous Chemicals Risk of Urban Residents in China: Analysis of Mediating Effect and Channel Preference of Response Action Decision Model
Authors: Wang Ziwei , Liu Yongkui , Liu Tiezhong
Published: October 2021

Because urban residents do not have a strong understanding of hazardous chemicals, they cannot effectively make response action decisions to ensure safety, protect lives, and reduce property damage. This paper constructs the Response Action Decision Model of hazardous chemicals, and analyzes the mediating effect of Information Processing and Threat Perception, as well as channel preferences of urban residents with different demographic characteristics. A total of 1700 questionnaires were collected in Chongqing, Tianjin, Fujian Zhangzhou, Shandong Zibo and Lanzhou, where there are significant hazardous chemicals factories. The results show that: Firstly, Information Processing and Threat Perception have significant mediating effects on the relationship between Mass Media, Social Media, Face-to-face communication and Response Action Decision in a single channel, which can effectively promote the spread effect of different channels, affecting the ways that urban residents make hazard response action decisions; secondly, Information Processing and Threat Perception do not have a mediating effect on the relationship between the channel combination of “Mass Media ↔ Social Media”, “Mass Media ↔ Face-to-face communication”, “Social Media ↔ Face-to-face communication” and Response Action Decision, and the channel combination can directly link to the Response Action Decision; thirdly, in terms of the extent that it affects urban residents to make response action decisions, Mass Media is greater than Social Media and greater than Face-to-face communication; fourthly, two demographic characteristics of gender and experience have a stronger moderating effect for the Mass Media channel, while other demographic characteristics have greater influences on the Response Action Decision Model; finally, the Response Action Decision Model can be better applied to those analyses and research which address threat perception of hazardous chemicals and response action decisions of urban residents in China.
Financial Inclusion Paradigm Shift in the Postpandemic Period. Digital-Divide and Gender Gap
Authors: Vasile Valentina , Panait Mirela , Apostu Simona-Andreea
Published: October 2021

Financial inclusion is strongly differentiated by age groups and countries and the pandemic has highlighted the increased gaps and inequalities but also the weaknesses of the system, in terms of flexibility, access and facilities of the customer-bank relationship and also from the perspective of the financial education of young generations and vulnerable people, active in the labor market. Based on the available data provided by the Global Findex database, and some findings after more than one year of COVID-19 crisis we outlined the main aspects of financial digitization, by categories of people and countries. At the same time, we identified the challenges and problems during the pandemic that significantly adjusted the consumption pattern of citizens and increased the need for on-line access for financial transactions. Starting from the analysis of the inequality of access to financial instruments in the last years, from the informational asymmetry in financial education and the challenges of the pandemic period, we underlined the main coordinates of changing the model of sustainable financial inclusion—based on five pillars—access, education, support tools, CSR and resilience. The research results highlight the need for convergence in providing opportunities to consider financial inclusion as a public good and an active tool to increase consumers’ satisfaction and the quality of life of individuals.
Emergency Response and Risk Communication Effects of Local Media during COVID-19 Pandemic in China: A Study Based on a Social Media Network
Authors: Jiang Lei , Huang Yujia , Cheng Haonan , Zhang Ting , Huang Lei
Published: October 2021

As the country where the COVID-19 was first reported and initially broke out, China has controlled the spread of the pandemic well. The pandemic prevention process included emergency response and risk communication, both of which could notably increase public participation, people’s anxiety has been alleviated, their confidence in the government has been enhanced, and the implementation of prevention and control measures has been understood. This study selected 157,283 articles published by 447 accounts across 326 cities in February 2020 from WeChat, the largest social media application in China, to systematically compare the spatial distributions in the effectiveness of emergency responses and risk communication. The results showed that there were significant regional differences in the effectiveness of emergency response and risk communication during the pandemic period in China. The effectiveness of emergency response and risk communication are related to the exposure risk to the COVID-19, the level of economy, culture, and education of the region, the type of accounts and articles, and the ranking of the articles in posts. The timeliness and distribution types of articles should take into account the psychological changes in communication recipients to avoid the dissemination of homogenized information to the masses and the resulting information receiving fatigue period.
Cardiovascular Disease Recognition Based on Heartbeat Segmentation and Selection Process
Authors: Boulares Mehrez , Alotaibi Reem , AlMansour Amal , Barnawi Ahmed
Published: October 2021

Assessment of heart sounds which are generated by the beating heart and the resultant blood flow through it provides a valuable tool for cardiovascular disease (CVD) diagnostics. The cardiac auscultation using the classical stethoscope phonological cardiogram is known as the most famous exam method to detect heart anomalies. This exam requires a qualified cardiologist, who relies on the cardiac cycle vibration sound (heart muscle contractions and valves closure) to detect abnormalities in the heart during the pumping action. Phonocardiogram (PCG) signal represents the recording of sounds and murmurs resulting from the heart auscultation, typically with a stethoscope, as a part of medical diagnosis. For the sake of helping physicians in a clinical environment, a range of artificial intelligence methods was proposed to automatically analyze PCG signal to help in the preliminary diagnosis of different heart diseases. The aim of this research paper is providing an accurate CVD recognition model based on unsupervised and supervised machine learning methods relayed on convolutional neural network (CNN). The proposed approach is evaluated on heart sound signals from the well-known, publicly available PASCAL and PhysioNet datasets. Experimental results show that the heart cycle segmentation and segment selection processes have a direct impact on the validation accuracy, sensitivity (TPR), precision (PPV), and specificity (TNR). Based on PASCAL dataset, we obtained encouraging classification results with overall accuracy 0.87, overall precision 0.81, and overall sensitivity 0.83. Concerning Micro classification results, we obtained Micro accuracy 0.91, Micro sensitivity 0.83, Micro precision 0.84, and Micro specificity 0.92. Using PhysioNet dataset, we achieved very good results: 0.97 accuracy, 0.946 sensitivity, 0.944 precision, and 0.946 specificity.
Impact of Environmental and Health Risks on Rural Households’ Sustainable Livelihoods: Evidence from China
Authors: Wang Wei , Zhang Chongmei , Guo Yan , Xu Dingde
Published: October 2021

China has entered a “post-poverty alleviation” era, where the achievement of sustainable livelihoods by farmers has become a focus. This study used the China Family Panel Studies (CFPS) database, which was constructed based on an analysis of the DFID sustainable livelihood framework, and built a sustainable livelihood index system for farmers using the entropy weight method to measure the weights of sustainable livelihood indexes and calculate a sustainable livelihood index. This study used the Tobit model to discuss the impacts of different types of risk on the achievement of a sustainable livelihood by farmers. The results showed that environmental risk, chronic disease risk, and major disease risk all had significant negative impacts on the ability of farmers to achieve a sustainable livelihood. The impacts of major disease and chronic disease risks on the achievement of a sustainable livelihood by farmers living in plain areas were stronger than those associated with environmental risk. In China, the environmental risks were complex and diverse and were the most important factors that affect the achievement of a sustainable livelihood by rural households in mountainous areas. Chronic disease risk was also an important adverse factor that affected the achievement of a sustainable livelihood by rural households in mountainous areas.
Ecological Water Requirement in Upper and Middle Reaches of the Yellow River Based on Flow Components and Hydraulic Index
Authors: Lu Shibao , Cai Wenting , Shao Wei , Taghizadeh-Hesary Farhad , Faisal Muhammad , Zhang Hongbo , Xue Yangang
Published: October 2021

Deterioration of the ecological environment in the upper and middle reaches of the Yellow River in China substantially impacts the growth and development of aquatic organisms in the drainage basin. This paper builds a conceptual model by applying flow components and fish ecological requirements relation with a relevant object of main fish in the upper and middle reaches of the Yellow River. The paper utilized the flow restoration method by employing the River2D model (two-dimensional model of river hydrodynamics and fish habitat), and a one-dimensional hydrodynamics HEC-RAS (hydrologic engineering center’s-river analysis system). The calculation result showed that the runoff condition required for Silurus lanzhouensis survival is that the monthly lowest flow in a year is 150 m3·s−1, and the lowest flow for suitable flow from April to October is 150 m3·s−1, and 300 m3·s−1 from November to March. The research result is closer to the actual condition and has more outstanding operability. Meanwhile, the results proposed the coupling method of ecological water requirement for the mainstream of the Yellow River. Moreover, the results portrayed the ecological flow process according to the upper envelope of minimum and maximum ecological water requirements of each fracture surface. It is regarded that the ecological flow process is deemed as the initial value of the reservoir regulation model.
Lived Experiences of Hospitalized COVID-19 Patients: A Qualitative Study
Authors: Venturas Montserrat , Prats Judith , Querol Elena , Zabalegui Adelaida , Fabrellas Núria , Rivera Paula , Casafont Claudia , Cuzco Cecilia , Frías Cindy E. , Olivé Maria Carmen , Pérez-Ortega Silvia
Published: October 2021

The COVID-19 pandemic has resulted in many hospitalized patients and deaths worldwide. Coronavirus patients were isolated from their relatives and visits were banned to prevent contagion. This has brought about a significant change in deeply rooted care habits in Mediterranean and Latin American countries where the family normally accompanies vulnerable hospitalized patients. The aim of this qualitative study was to examine the hospitalization experience of COVID-19 patients and their family members. A phenomenological qualitative approach was used. Data collection included inductive, in-depth interviews with 11 COVID-19 hospitalized patients. The mean age of patients was 55.4 years and 45% were female. Nearly 50% required Intensive Care Unit (ICU) admission. Ten meaningful statements were identified and grouped in three themes: Positive and negative aspects of the care provided, the patient’s perspective, and perception of the experience of the disease. In conclusion, COVID-19 patients, aware of the severity of the pandemic, were very adaptable to the situation and had full confidence in health professionals. Patient isolation was perceived as necessary. Technology has helped to maintain communication between patients and relatives.
Landslide Susceptibility Assessment Using an AutoML Framework
Authors: Bruzón Adrián G. , Arrogante-Funes Patricia , Arrogante-Funes Fátima , Martín-González Fidel , Novillo Carlos J. , Fernández Rubén R. , Vázquez-Jiménez René , Alarcón-Paredes Antonio , Alonso-Silverio Gustavo A. , Cantu-Ramirez Claudia A. , Ramos-Bernal Rocío N.
Published: October 2021

The risks associated with landslides are increasing the personal losses and material damages in more and more areas of the world. These natural disasters are related to geological and extreme meteorological phenomena (e.g., earthquakes, hurricanes) occurring in regions that have already suffered similar previous natural catastrophes. Therefore, to effectively mitigate the landslide risks, new methodologies must better identify and understand all these landslide hazards through proper management. Within these methodologies, those based on assessing the landslide susceptibility increase the predictability of the areas where one of these disasters is most likely to occur. In the last years, much research has used machine learning algorithms to assess susceptibility using different sources of information, such as remote sensing data, spatial databases, or geological catalogues. This study presents the first attempt to develop a methodology based on an automatic machine learning (AutoML) framework. These frameworks are intended to facilitate the development of machine learning models, with the aim to enable researchers focus on data analysis. The area to test/validate this study is the center and southern region of Guerrero (Mexico), where we compare the performance of 16 machine learning algorithms. The best result achieved is the extra trees with an area under the curve (AUC) of 0.983. This methodology yields better results than other similar methods because using an AutoML framework allows to focus on the treatment of the data, to better understand input variables and to acquire greater knowledge about the processes involved in the landslides.
Social Participation and Survival in Widowed Persons: Results of the Taiwan Longitudinal Study on Aging
Authors: Hsiao Yu-Han , Lee Meng-Chih , Yeh Chih-Jung , Tai Chi-Jung , Lee Shiuan-Shinn
Published: October 2021

It has been considered that widowed persons have a higher risk of death. This study intended to explore whether social participation could improve this trend. A longitudinal study database was constructed to explore the trend of survival and its change with social participation in widowed persons. The Taiwan Longitudinal Study on Aging (TLSA), based on four consecutive waves of longitudinal follow-up data in 1999, 2003, 2007, and 2011 was linked with the National Death Registry from 1999 through 2012. In total, there were 1417 widowed persons and 4500 nonwidowed persons included in this study, excluding divorced and never-married people. The survival trend analysis was carried out with social participation as the main predictive factor stratified for comparative analysis. Our results showed that the widowed were older than the nonwidowed, were female-dominant, had a lower education level, were more economically stressed, and were less likely to engage in regular exercise, and thus showed generally poorer health; for example, being more vulnerable to having chronic diseases, disability with the Activities of Daily Living (ADL), cognitive impairment with the Short Portable Mental State Questionnaire (SPMSQ), and depression with The Center for Epidemiological Studies-Depression (CES-D). The death risk of the widowed was significantly higher than that of the nonwidowed, but the death trend for those with social participation was significantly lower than that of their counterparts in both the widowed and nonwidowed. After matching with gender and age for widowed persons, the widowed with social participation had a significantly lower risk of death (adjusted hazard ratio (HR), 0.83; 95% confidence interval (CI), 0.71–0.98) compared to the widowed without social participation. It was concluded that social participation can improve the death risk for the widowed, and it is worthily included in health promotion plans and social welfare services for widowed persons.
Design and Validation of the INCUE Questionnaire: Assessment of Primary Healthcare Nurses’ Basic Training Needs in Palliative Care
Authors: García-Salvador Isidro , Chisbert-Alapont Encarna , Antonaya Campos Amparo , Casaña Mohedo Jorge , Hurtado Navarro Clara , Fernández Peris Silvia , Bonías López José , De la Rica Escuín Maria Luisa
Published: October 2021

Many instruments have been created to measure knowledge and attitudes in palliative care. However, not only is it important to acquire knowledge, but also that this knowledge should reach patients and their relatives through application in clinical practice. This study aimed to develop and psychometrically test the INCUE questionnaire (Investigación Cuidados Enfermeros/Investigation into Nurses’ Care Understanding of End-of-Life) to assess the basic training needs of primary or home healthcare nurses in palliative care. A questionnaire was developed based on the classical theory of tests and factor analysis models. Initially, 18 experts developed 67 items in two blocks and determined content validity by two rounds of expert panels. Exploratory factor analysis and reliability testing were conducted with a non-probabilistic sample of 370 nurses. Some items were observed to have very low homogeneity indices or presented convergence problems and were eliminated. Questionnaire reliability was 0.700 in the theoretical block (KR20 Index) and 0.941 in the practical block (Cronbach’s alpha). The model converges and shows an adequate fit, specifically CFI = 0.977, TLI = 0.977 and RMSEA = 0.05. The correlation between the two factors in the model is ρ = 0.63. The questionnaire objectively evaluates primary or home healthcare nurses’ knowledge of palliative care and its practical application, thereby facilitating more efficient training plans.
COVID-19 among Healthcare Workers: A Prospective Serological-Epidemiological Cohort Study in a Standard Care Hospital in Rural Germany
Authors: Hoffmann Stephanie , Schiebel Juliane , Hufert Frank , Gremmels Heinz-Detlef , Spallek Jacob
Published: October 2021

Healthcare workers (HCW) play a vital role in the SARS-CoV-2 pandemic control. The aim of this study was to assess the prevalence of SARS-CoV-2 antibodies and the risk of COVID-19 infections in a cohort of HCW from four different risk groups (from intensive care unit to administration) of a hospital of a primary care level in rural Germany. The outcomes were monthly measures of antibody seroprevalence over a period of 6 months. Overall, a seroprevalence of 13.41% was determined, with significantly higher prevalence rates among HCW working in areas with more frequent contact to confirmed or suspected cases (30.30%, p = 0.003). The group specific differences in the risk of infection from COVID-19 were detected, as HCW groups with frequent exposure seemed to have an increased risk (RR = 3.18, p = 0.02; CI95 1.09–9.24). The findings contribute to the epidemiological understanding of the virus spread in an unvaccinated population group, which is highly relevant for the pandemic management.
Assessment of Ecosystem Service Supply, Demand, and Balance of Urban Green Spaces in a Typical Mountainous City: A Case Study on Chongqing, China
Authors: Luo Chang , Li Xiangyi
Published: October 2021

Objective measurement of the supply–demand of ecosystem services (ESs) has received increasing attention from recent studies. It reflects the relationship between green spaces and human society. However, these studies rarely assess the mountainous cities. To fill this gap, this study takes a typical mountainous city as a research case to reveal the supply–demand relationship of ecosystem services, then development and management strategies are proposed for different districts according to their spatial differentiation characteristics. Results shows that: (1) there are differences of ESs supply between each district, and supply from Banan District is significantly higher than others. (2) The demands for ES also vary widely, which are higher in the core urban areas. (3) There are different degrees of imbalance between supply and demand in each district. We classified green spaces into four types based on their supply–demand characteristics, and optimization strategies are proposed. We found that most of the districts are lack of ES supply while there is a relatively high demand for ES in Chongqing, and the balance of supply and demand between different districts varies greatly. Our study indicates that targeted urban green spaces strategies for different districts must be considered to adequately optimize ES in mountainous cities.
Smoking a Dangerous Addiction: A Systematic Review on an Underrated Risk Factor for Oral Diseases
Authors: Ahmed Naveed , Arshad Sohaib , Basheer Syed Nahid , Karobari Mohmed Isaqali , Marya Anand , Marya Charu Mohan , Taneja Pratibha , Messina Pietro , Yean Chan Yean , Scardina Giuseppe Alessandro
Published: October 2021

Despite growing knowledge of the adverse effects of cigarette smoking on general health, smoking is one of the most widely prevalent addictions around the world. Globally, about 1.1 billion smokers and over 8 million people die each year because of cigarette smoking. Smoking acts as a source for a variety of oral and systemic diseases. Various periodontal issues such as increased pocket depth, loss of alveolar bone, tooth mobility, oral lesions, ulcerations, halitosis, and stained teeth are more common among smokers. This systematic review was conducted according to the guidelines from PRISMA, and research articles were retrieved from the Web database sources on 31 May 2021. The quality of research articles was ensured by the type of evidence from combined schema incorporating as schema-13 evidence type description, Cochrane health promotion and public health field (CHPPHF), and the health gains notation framework-14 screening question for quality assessment of qualitative and quantitative studies. Smokers have been found to have bleeding on probing, periodontal pockets, and clinical attachment loss compared to nonsmokers. Oral and respiratory cancers are among the most lethal known diseases caused by cigarette smoking and other commonly occurring sequelae such as stained teeth, periodontal diseases, etc.
Pilot Ecological Momentary Assessment Study of Subjective and Contextual Factors Surrounding E-Cigarette and Combustible Tobacco Product Use among Young Adults
Authors: Camenga Deepa R. , Haeny Angela M. , Krishnan-Sarin Suchitra , O’Malley Stephanie S. , Bold Krysten W.
Published: October 2021

Background: Dual use of e-cigarettes and combustible tobacco products is common in young adults. We aimed to explore how ratings of subjective and contextual factors differed between discrete episodes of e-cigarette use vs. combustible tobacco product smoking among a sample of young adults. Methods: Young adults (N = 29, ages 18–30) who used e-cigarettes and ≥1 combustible tobacco product at least once weekly completed a 1-week smartphone-based ecological momentary assessment (EMA). Twice daily random prompts assessed past-15-min use of tobacco products, ratings of subjective factors (e.g., negative affect, craving), and contextual factors related to activity, location, and companionship. A multivariable GEE model assessed whether subjective or contextual factors were associated with e-cigarette vs. combustible tobacco product episodes. Results: 184 tobacco use episodes were reported (39.7% e-cigarette, 60.3% combustible tobacco product). High baseline cigarette dependence, as measured by the Fagerström Test for Cigarette Dependence, was associated with lower odds of e-cigarette vs. combustible tobacco product episodes (aOR 0.01, 95% CI (0.002–0.08); p < 0.001). Neither between- or within-subjects negative affect or craving scores were associated with e-cigarette use. Activities of eating/drinking (aOR 0.20, 95% CI (0.08–0.49); p = 0.001) and being in the companionship of a person who smoked cigarettes (aOR 0.13, 95% CI (0.04–0.43); p = 0.001) were associated with lower odds of e-cigarette vs. combustible tobacco product use episodes. However, traveling (aOR 12.02, 95% CI (3.77–38.26); p ≤ 0.001) and being in a public space (aOR 2.76, 95% CI (1.10–6.96); p = 0.03) were associated with higher odds of e-cigarette than combustible tobacco product use episodes. Conclusions: This pilot data suggests that unique contextual factors may be associated with e-cigarette use, compared to combustible tobacco smoking in a sample of young adults who use both e-cigarettes and combustible tobacco products. Future research with larger samples is needed to better characterize varying contexts and cues for tobacco use among young adults who are dual users.
Coupling Cellular Automata and a Genetic Algorithm to Generate a Vibrant Urban Form—A Case Study of Wuhan, China
Authors: Wang Renyang , He Qingsong , Zhang Lu , Wang Huiying
Published: October 2021

Enhancing urban vitality is a key goal for both the government and ordinary urban residents, and creating this vitality is emphasized in China’s urban development strategy. Enhancing urban vitality through the rational design of urban forms is a leading topic of Western urban research. An urban growth pattern (UGP) reflects the dual characteristics of a static pattern and the dynamic evolution of the external urban form. It affects urban vitality by influencing the spatial allocation of internal structural elements and patterns in the adjacent location. The cellular automata (CA) mode can effectively simulate the aggregation process of urban growth (infilling expansion or edge expansion). However, it does not simulate the diffusion of urban growth, specifically the evolution of outlying expansion. In addition, CA focuses on learning, simulating, and building knowledge about geographic processes, but does not spatially optimize collaborative land use against multiple objectives or model multi-scale land use. As such, this paper applies a coupling model called the “promoting urban vitality model,” based on cellular automata (CA) and genetic algorithm (GA) (abbreviated as UV-CAGA). UV-CAGA optimally allocates cells with different UGPs, creating a city form that promotes urban vitality. Wuhan, the largest city in Central China, was selected as a case study to simulate and optimize its urban morphology for 2025. The main findings were as follows. (1) The urban vitality of the optimized urban form scheme was 4.8% higher than the simulated natural expansion scheme. (2) Compared to 2015, after optimization, the simulated sizes of the newly increased outlying, edge, and infilling areas in 2025 were 6.51 km2, 102.69 km2, and 23.48 km2, respectively; these increases accounted for 4.90%, 77.32%, and 17.68%, respectively, of the newly increased construction land area. This indicated that Wuhan is expected to have a very compact urban form. (3) The infilling expansion type resulted in the highest average urban vitality level (0.215); the edge expansion type had the second highest level (0.206); outlying growth achieved the lowest vitality level (0.199). The UV-CAGA model proposed in this paper improves on existing geographical process simulation and spatial optimization models. The study successfully couples the “bottom-up” CA model and “top-down” genetic algorithm to generate dynamic urban form optimization simulations. This significantly improves upon traditional CA models, which do not simulate the “diffusion” process. At the same time, the spatial optimization framework of the genetic algorithm in the model also provides insights related to other effects related to urban form optimization, such as urban environmental security, commuting, and air pollution. The integration of related research is expected to enrich and improve urban planning tools and improve the topic’s scientific foundation.
IL13 May Play an Important Role in Developing Eosinophilic Chronic Rhinosinusitis and Eosinophilic Otitis Media with Severe Asthma
Authors: Shimizu Hideyasu , Hayashi Masamichi , Kato Hisayuki , Nakagawa Mitsuru , Imaizumi Kazuyoshi , Okazawa Mitsushi
Published: October 2021

A woman in her 50s was a super responder to benralizumab administered for the treatment of severe bronchial asthma (BA) with eosinophilic chronic rhinosinusitis with nasal polyp (ECRS) and eosinophilic otitis media (EOM). She exhibited the gradual exacerbation of ECRS/EOM despite good control of BA approximately 1 year after benralizumab initiation. Therefore, the treatment was switched to dupilumab, and the condition of the paranasal sinuses and middle ear greatly improved with the best control of her asthma. The patient reported that her physical condition was the best of her life. However, she developed a pulmonary opacity on chest computed tomography after 6 months. Histological examination of the lung parenchyma and cell differentiation of the bronchoalveolar lavage fluid indicated atypical chronic eosinophilic pneumonia, and treatment was switched to mepolizumab. Similarly to the period of benralizumab treatment, exacerbation of ECRS/EOM reduced her quality of life approximately 10 months after the administration of mepolizumab. Dupilumab was again introduced as a replacement for mepolizumab. The clinical course and consideration of the interaction between inflammatory cells led us to speculate that interleukin-13 could play a key role in the development of ECRS/EOM with severe BA.
A Titanium (IV)–Dithiophenolate Complex and Its Chitosan Nanocomposite: Their Roles towards Rat Liver Injuries In Vivo and against Human Liver Cancer Cell Lines
Authors: Shaban Nadia Z. , Yehia Salah A. , Awad Doaa , Shaban Shaban Y. , Saleh Samar R.
Published: October 2021

Titanium (IV)–dithiophenolate complex chitosan nanocomposites (DBT–CSNPs) are featured by their antibacterial activities, cytotoxicity, and capacity to bind with DNA helixes. In this study, their therapeutic effects against rat liver damage induced by carbon tetrachloride (CCl4) and their anti-proliferative activity against human liver cancer (HepG2) cell lines were determined. Results of treatment were compared with cisplatin treatment. Markers of apoptosis, oxidative stress, liver functions, and liver histopathology were determined. The results showed that DBT–CSNPs and DBT treatments abolished liver damage induced by CCl4 and improved liver architecture and functions. DNA fragmentation, Bax, and caspase-8 were reduced, but Bcl-2 and the Bcl-2/Bax ratios were increased. However, there was a non-significant change in the oxidative stress markers. DBT–CSNPs and DBT inhibited the proliferation of HepG2 cells by arresting cells in the G2/M phase and inducing cell death. DBT–CSNPs were more efficient than DBT. Low doses of DBT and DBT–CSNPs applied to healthy rats for 14 days had no adverse effect. DBT and DBT–CSNP treatment gave preferable results than the treatment with cisplatin. In conclusion, DBT–CSNPs and DBT have anti-apoptotic activities against liver injuries and have anti-neoplastic impacts. DBT–CSNPs are more efficient. Both compounds can be used in pharmacological fields.
Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment
Authors: Capitani Nagaja , Patrussi Laura , Baldari Cosima T.
Published: October 2021

Similar to Janus, the two-faced god of Roman mythology, the tumor microenvironment operates two opposing and often conflicting activities, on the one hand fighting against tumor cells, while on the other hand, favoring their proliferation, survival and migration to other sites to establish metastases. In the tumor microenvironment, cytotoxic T cells—the specialized tumor-cell killers—also show this dual nature, operating their tumor-cell directed killing activities until they become exhausted and dysfunctional, a process promoted by cancer cells themselves. Here, we discuss the opposing activities of immune cells populating the tumor microenvironment in both cancer progression and anti-cancer responses, with a focus on cytotoxic T cells and on the molecular mechanisms responsible for the efficient suppression of their killing activities as a paradigm of the power of cancer cells to shape the microenvironment for their own survival and expansion.
Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis
Authors: Burg Thibaut , Rossaert Elisabeth , Moisse Matthieu , Van Damme Philip , Van Den Bosch Ludo
Published: October 2021

Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disorder of the motor system. While the etiology is still incompletely understood, defects in metabolism act as a major contributor to the disease progression. Recently, histone deacetylase (HDAC) inhibition using ACY-738 has been shown to restore metabolic alterations in the spinal cord of a FUS mouse model of ALS, which was accompanied by a beneficial effect on the motor phenotype and survival. In this study, we investigated the specific effects of HDAC inhibition on lipid metabolism using untargeted lipidomic analysis combined with transcriptomic analysis in the spinal cord of FUS mice. We discovered that symptomatic FUS mice recapitulate lipid alterations found in ALS patients and in the SOD1 mouse model. Glycerophospholipids, sphingolipids, and cholesterol esters were most affected. Strikingly, HDAC inhibition mitigated lipid homeostasis defects by selectively targeting glycerophospholipid metabolism and reducing cholesteryl esters accumulation. Therefore, our data suggest that HDAC inhibition is a potential new therapeutic strategy to modulate lipid metabolism defects in ALS and potentially other neurodegenerative diseases.
Therapeutic Effect of α-MSH in Primary Cultured Orbital Fibroblasts Obtained from Patients with Thyroid Eye Disease
Authors: Cheng Pei-Wen , Tsai Pei-Jhen , Tai Ming-Hong , Bee Youn-Shen
Published: October 2021

Inflammation, hyaluronan production, and adipogenesis are the main pathological events leading to thyroid eye disease (TED). α-Melanocytemelanocyte-stimulating hormone (α-MSH) is a well-known tridecapeptidetreatment for several inflammatory disorders including sepsis syndrome, acute respiratory distress syndrome, rheumatoid arthritis, and encephalitis. Here, we investigated the effect of α-MSH treatment on TED. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Lactate Dehydrogenase (LDH) assays were performed to analyze the effect of α-MSH on cell viability and it’s toxicity. Using primary cultures of orbital fibroblasts from TED patients and non-TED as control, we examined the effects of α-MSH on proinflammatory cytokine production induced by interleukin (IL)-1β, further analyzed by real-time reverse transcription-polymerase chain reaction (qPCR) and western blotting. Immunofluorescence staining assay and qPCR were performed to examine proopiomelanocortin (POMC) expression, the upstream neuropeptide of α-MSH in TED patients and non-TED control. Treatment with non-cytotoxic concentrations of α-MSH resulted in the dose-dependent inhibition of mRNA and protein levels (p < 0.05) for IL-1β-induced inflammatory cytokines: IL-6, IL-8, MCP-1, ICAM-1, and COX-2. The expression of POMC mRNA and protein were significantly higher in TED patients compared to non-TED control (p < 0.05). Our data show significant inhibitory effects of α-MSH on inflammation, POMC production in orbital fibroblasts. At present, this is the first in vitro preclinical evidence of α-MSH therapeutic effect on TED. These findings indicate that POMC and α-MSH may play a role in the immune regulation of TED and can be a potential therapeutic target.
Irisin Protects the Human Placenta from Oxidative Stress and Apoptosis via Activation of the Akt Signaling Pathway
Authors: Kohan-Ghadr Hamid-Reza , Armistead Brooke , Berg Mikaela , Drewlo Sascha
Published: October 2021

Irisin is a newly discovered exercise-mediated polypeptide hormone. Irisin levels increase during pregnancy however, women with preeclampsia (PE) have significantly lower levels of Irisin compared to women of healthy pregnancies. Even though many studies suggest a role of Irisin in pregnancy, its function in the human placenta is unclear. In the current study, we aimed to understand key roles of Irisin through its ability to protect against apoptosis is the preeclamptic placenta and in ex vivo and in vitro models of hypoxia/re-oxygenation (H/R) injury. Our studies show that Irisin prevents cell death by reducing pro-apoptotic signaling cascades, reducing cleavage of PARP to induce DNA repair pathways and reducing activity of Caspase 3. Irisin caused an increase in the levels of anti-apoptotic BCL2 to pro-apoptotic BAX and reduced ROS levels in an in vitro model of placental ischemia. Furthermore, we show that Irisin treatment acts through the Akt signaling pathway to prevent apoptosis and enhance cell survival. Our findings provide a novel understanding for the anti-apoptotic and pro-survival properties of Irisin in the human placenta under pathological conditions. This work yields new insights into placental development and disease and points towards intervention strategies for placental insufficiencies, such as PE, by protecting and maintaining placental function through inhibiting hypoxic ischemia-induced apoptosis.