bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación y análisis de modelos de infraestructura logística, dentro de la zona de comercio internacional en La Tebaida, departamento del Quindío, hacia el sector agroindustrial
Authors: Laguna Chacón Jaime Ricardo
Published: August 2022

Premio de Estudios Iberoamericanos Grupo La Rábida (2015). Ciencias Sociales y Jurídicas. Los procesos de internacionalización de la economía colombiana requieren desarrollar estudios de infraestructura logística orienados al comercio internacional a fin de conocer a fondo la problemática existente en este campo. Las grandes limitaciones que la zona portuaria de Buenaventura ha puesto al descubierto las ingentes posibilidades del departamento del Quindío como zona competitiva de amortización al flujo de carga comprometida en el comercio exterior.
Perfil toxicológico de los sedimientos del río Magdalena usando como modelo biológico "Caenorhabditis elegans"
Authors: Olivero-Verbel Jesus , Tejeda-Benitez Lesly
Published: August 2022

Premio de Estudios Iberoamericanos Grupo La Rábida (2015). Área Científico-Técnica. El río Magdalena, atraviesa Colombia y desemboca en el mar Caribe, siendo el sumidero de aguas residuales e industriales a lo largo de su recorrido. Estos vertidos de diversas características, contienen contaminantes que por sus propiedades fisicoquímicas permanecen en los sedimentos, donde son incorporados al plancton, entrando en la cadena alimenticia en procesos de bioacumulación y biomagnificación, ocasionando considerables problemas de toxicidad en todos los niveles tróficos. En esta investigación fue empleado el nemátodo Caenorhabditis elegans como modelo biológico para la evaluación toxicológica de los sedimentos de este cuerpo de agua.
Validación de la cromatografía líquida de alto rendimiento acoplada a espectrometría de masas para determinar albendazol sulfóxido en plasma humano
Authors: Rosales-Rimache Jaime , Santiváñez Saúl , Moreno-Exebio Luis , Grande Miguel , Flores-Rodríguez María , Eguiluz María , García Hugo
Published: August 2022

Context: Albendazole is used in the treatment of cysticercosis and hydatid disease, and its prolonged administration can generate adverse effects attributed to the active metabolite, albendazole sulfoxide (ABZSO), whose measurement requires validated methods that help monitor patients under treatment. Aims: To validate a high-performance liquid chromatography method with mass detection (HPLC-MS) for the determination of ABZSO in human plasma. Methods: HPLC-MS was performed on C18 columns (100 × 4.6 mm × 3.5 µm) and mobile phase composed of methanol, water and ammonia solution (25%) (800:200:0.1 v /v/v) at a flow rate of 0.5 mL/minute. The calibration curve was built with an albendazole standard, and detection in a triple quadrupole system. Results: The method was linear (1-1500 ng/mL, R2 = 0.999) with a detection limit of 1 ng/mL. ABZSO concentrations at 1, 5, 50, 100, 200, 500, 1000, and 1500 ng/mL had relative standard deviations of 10.4, 8.4, 7.8, 2.9, 7.4, 3.2, 3.4 and 1.3%. It was highly precise with a mean coefficient of variation of 1.411%, and accurate with a bias of -14.7; 2.8 and -0.8% in ABZSO concentrations of 5, 500 and 1000 ng/mL. The average recovery was 89.2%, and the stability of ABZSO after refrigeration had an average coefficient of variation of 2.3%. Conclusions: The HPLC-MS method is valid and reliable to determine ABZSO, and could be used in pharmacokinetic, bioequivalence, and other studies that evaluate the biological monitoring of patients receiving oral treatment with albendazole.
LEISURE INVOLVEMENT AND PLACE ATTACHMENT ON SHOPPING MALL REVISIT INTENTION: THE MEDIATING ROLE OF QUALITY OF LIFE
Authors: M.S Shaheera Ahmad  , M.S Shaheera Ahmad
Published: August 2022

This study investigates the impact of leisure involvement, and place attachment on revisit intention with the mediating role of quality of life. This survey was composed of 300 individuals in a shopping mall in Lahore, Pakistan. The data was analyzed through Partial Least Square – Structural Equation Modeling (PLS-SEM). The findings indicated that leisure involvement and quality of life predict the place attachment and customers revisit intention. The results show the positive and significant relationship between leisure involvement (LI) and quality of life (QOL); leisure involvement (LI) with place attachment (PA); revisit intention (RI) and QOL with place attachment and revisit intention. The study advances in theory explaining the mediating role of quality of life in consumption in Shopping Malls and presents managerial recommendations that can be applied during and after Covid-19.
IMPACT OF PARENTING STYLES ON ACADEMIC ACHIEVEMENTS OF UNIVERSITY STUDENTS IN BAHAWALPUR
Authors: Fatima Khurram Bukhari  , Samar Fahd  , Sana Fayyaz  , Sabiha Iqbal  , Mahnoor Anwar
Published: August 2022

This study intended to explore the impact of different parenting styles on academic achievements of the university students. Randomly selected 91 male and 109 female students from different departments of the Islamia University of Bahawalpur were participated in the study. The data was collected with their consent through two scales. The first scale was parental Authority Questionnaire Revised version used to measure Parental authority. Second was Academic Performance scale which used to measure academic performance of students. The results were derived through statistical analysis of the data, using SPSS software. As hypothesized, it was found out that the authoritative parenting style boosts the academic achievements of the university students. Parenting styles also have significant impact on the academic achievements. Gender and family system was found significantly different but the locality of the students was insignificant. Present research has contributed in gaining the deeper understanding of the constructs understudy.
DETERMINANTS OF CONSUMER RETAIL FORMAT CHOICE BETWEEN TRADITONAL AND MODERN RETAILERS IN PAKISTAN
Authors: Amna Saeed  , Hammad Badar
Published: August 2022

The retail sector is experiencing a transformation with the entry of modern retailers in Pakistan. As a result, now consumers have a choice of shopping either at traditional or modern retailers. The study is aimed at finding out the determinants of consumer retail format choice between traditional and modern retailers. To this end, primary data were collected through personal interviews of 250 respondents who were intercepted randomly while shopping at different retail places in Lahore and Faisalabad - the two highly populated and major cities in Pakistan. Descriptive statistics, factor analysis, and binary logit model were employed for the analysis of data. Results indicated age, being accompanied with family while shopping, income and five store-related attributes such as store design and environment, promotion, product quality, employee behavior and location as the important determinants of consumer retail format choice in Pakistan. The study recommends that traditional retailers need to upgrade their businesses and align themselves with changing consumer preferences. Modern retailers should make their store design and environment more attractive, ensure product quality and improve promotional strategies and employee responsiveness for enhancing their customer base. Findings can be useful to the strengthening of both the retail formats in Pakistan.
Numerical analysis of nonlinear parabolic problems with variable exponent and L^1 data
Authors: Ouaro Stanislas , Rabo Noufou
Published: August 2022

In this paper, we make the numerical analysis of the mild solution which is also an entropy solution of parabolic problem involving the \(p(x)-\)Laplacian operator with \(L^1-\) data.
A Study on Impact of COVID-19 a Global Pandemicon Indian Economy: With special Context to Goods and Service Tax.
Authors: Gautam Arun
Published: August 2022

Study is intended to emphasis significant impact of covid-19 a global pandemic situation in Indian economy. Indian economy consists various segments like, rail system, ecommerce industry, automobile sector, restaurants industry, information technology and software services, travels and tourism industry and lots of others industry having vital role in Indian economy. Economy was running as usual and suddenly at the end of third quarter of fiscal year 2019-20 a novel corona virus entered in Indian territory and start to infect the peoples silently. Gradually number of infected persons increased and a global pandemic situation been declared by the concerned authorities. Just within two months it’s been spread across the country and survival gone typical in normal course. Hence Indian government decided to complete lockdown nationwide to cope up with this global pandemic situation. Indian economy been sickening due to global pandemic situation. Every industry adversely affected by this covid-19 a global pandemic. Financial as well as convenience crises been arisen. To run and maintain economy every government required funds which is collected in form of taxes like, income tax, goods and service tax, etc. goods and services tax leviable only on supply of goods or services. Now in nationwide lockdown, supply of goods and services are completely affected adversely. Hence GST collection will also be affected adversely.
Does Growth Sustainability Affect Stock Value? An Empirical Investigation in Indian Banking Sector
Authors: Panda Shradhanjali , Mitra Ananya
Published: August 2022

To satisfy the investor’s desire to quick returns, companies had to often trade-off their sustainability and long term growth. The growth rate of a company has the quickest impact on true value of a stock.  The paper tried to study how the growth sustainability (using ROE and retention ratio) affects the intrinsic value of a stock and its deviation from the market value. The paper is divided into two segments. The first part deals with financial relationship between Discounted Cash Flow, P/E Multiplier and Market Value. In the second part the paper uses econometric tools to study the short run association between the variables. The comprehensive empirical work aims at identifying the over-pricing or the under-pricing of the stocks at different phases of growth rates. Econometric tools like ADF, VAR, Grangers Causality and Dynamic OLS is used. Findings of the present work show the divergence between this estimated true and market value of stocks is not significant (at 5% significance level) for the banks that follow steady growth sustainability. Thus the paper concludes at testing the impact of growth sustainability on correct market mechanism of the stock pricing.
HUMAN RESOURCE MANAGEMENT OF PT. NESTLE INDONESIA PANJANG FACTORY LAMPUNG, INDONESIA
Authors: Hutasoit Maylani Florensi
Published: August 2022

The objectives of this study are: (1) to determine the application of the basic functions of management, namely planning, organizing, Actuating and supervising the Agricultural Service Department of PT. Nestlé Indonesia-Panjang Factory; and (2) knowing the implementation of operational functions in the field of human resources, namely procurement, development, compensation, integration, maintenance and termination of labor for human resources at the Agricultural Service Department of PT. Nestlé Indonesia-Panjang Factory. Activities carried out at PT. Nestle Indonesia, having its address at Jalan Raya Bakauheni KM. 13 Panjang Village, Panjang District, Bandar Lampung. This activity was carried out using interviews, observation, data recording, direct observation and field work as well as conducting a literature study. The form of activities carried out is in the form of work internships with the following activities, that are interviews, observation, and searching literature. The conclusion of this study is that the implementation of basic functions or human resource management in the Agricultural Service Department of PT Nestle Indonesia Factory Panjang has been implemented properly. Procurement of manpower in the Agricultural Service Department of PT Nestle Indonesia Panjang Factory is based on manpower needs.
ESPAÇO E COVID-19:
Authors: Diniz Alexandre M. A. , Alvim Ana M. M. , Lopes Erick V. P. , Diniz Gabriela L. , Souto Giovanna R. , Silva Glaycon S. A. , Carvalho Paulo F. B. , Guimarães Silvio Jamil Ferzoli
Published: August 2022

Esta pesquisa resulta de uma análise abrangente da literatura recente sobre a pandemia de COVID-19 e suas interações com aspectos espaciais. São objetivos deste artigo i) demonstrar os primeiros resultados da pesquisa de sistematização de bibliografias que constituem interlocuções entre a Geografia e as áreas da Saúde, tendo como foco investigações acerca da pandemia de COVID-19 em diferentes escalas geográficas; ii) destacar os principais periódicos e origens dos artigos que apresentam tal interlocução; iii) evidenciar eixos temáticos estruturantes do debate sobre a dispersão do patógeno em questão; e iv) apontar lacunas de pesquisa que sejam úteis à formulação de pesquisas futuras. Para tanto, realizou-se uma revisão sistemática da literatura baseada na seleção de 28 palavras-chave comumente presentes em estudos geográficos, às quais somaram-se termos relativos à COVID-19. O Portal de Periódicos da CAPES foi a principal fonte de pesquisa, tendo sido identificadas 8.319 publicações revisadas por pares entre janeiro de 2020 até o presente momento. Com as filtragens baseadas em critérios de relevância, e concordância com a pergunta inicial da pesquisa “o que sabemos sobre a dimensão espacial da COVID-19?”, reduziu-se a 173 o montante de artigos analisados. Os resultados evidenciam expressivo número de produções associado ao Norte Global, embora no Sul Global pesquisadores brasileiros se destaquem nos estudos que associam a abordagem espacial à pandemia de COVID-19. Também concluímos que há um consenso entre pesquisadores do mundo, devido ao significativo volume de produções que aspectos como a identificação de cluster e padrões espaciais; a mobilidade; o comportamento humano; o meio ambiente; o ambiente construído; a dimensão social e a integração entre dimensão social e ambiental; são extremamente relevantes para a compreensão e análise sobre a pandemia de COVID-19.
TURISMO EM ÁREAS NATURAIS:
Authors: Oppliger Emilia Alibio , Oliveira Ademir Kleber Morbeck de , Bassinello Patrícia Zaczuk
Published: August 2022

A dinâmica inerente ao turismo exige que mercado e academia estejam integrados para responder às lacunas dessa área de conhecimento através do uso rigoroso do método. Os objetivos desta pesquisa são: discutir diferentes modalidades de turismo apresentadas pelo mercado e desenvolvidas em áreas naturais; analisar as dificuldades de compreensão teórica relacionada às semelhanças entre essas modalidades. O método utilizado delimitou três categorias de análise para averiguar modalidades e conceitos: (1) princípio, (2) elemento do produto turístico e (3) motivação, o que permitiu apresentar um conceito de ‘turismo em áreas naturais’ mais abrangente e assertivo do ponto de vista científico.
DESENVOLVIMENTO LOCAL ENDÓGENO A PARTIR DA UTILIZAÇÃO DE ESPÉCIES DA CAATINGA COM POTENCIAL AGROINDUSTRIAL:
Authors: Chaves James Lima , Lima José Raimundo Oliveira
Published: August 2022

Esta pesquisa objetiva analisar, no Assentamento Palestina, em Cravolândia-BA, aspotencialidades para o desenvolvimento local endógeno considerando o zoneamento daárea, aptidões do solo, percepção dos próprios assentados sobre as oportunidades,fraquezas e ameaças existentes, bem como experiências semelhantes que se apoiaram nouso de tecnologias sociais como ferramentas facilitadoras da convivência no semiárido.Sobre os aspectos metodológicos, tivemos como sustentação teóricas referências quecompõem as categorias centrais do nosso objetivo, assim como instrumentos documentaispara alcançar os elementos locais atinentes ao assentamento. Como resultado, inferimosque o reconhecimento do semiárido como uma região próspera, aliado ao uso daspotencialidades endógenas, como por exemplo, das espécies com aplicaçõesagroindustriais, constituem um caminho para que as áreas de reserva legal possam serbeneficiadas, articulando as tecnologias sociais ao desenvolvimento local endógeno dacomunidade.
A ESPOLIAÇÃO DA VIDA E A JUSTIÇA AMBIENTAL
Authors: Nascimento Victor de Matos , Teixeira Rodrigo Corrêa , Oliveira Marina Paula
Published: August 2022

O presente artigo se propõe a responder a seguinte questão: seria possível compatibilizar a conservação da natureza e a acumulação de capital nas atuais configurações do capitalismo? A partir de uma revisão bibliográfica, é feita uma reflexão crítica, amparada sobretudo na discussão de David Harvey sobre acumulação por espoliação, no intuito de questionar os elementos intrínsecos ao capitalismo moderno que dificultam esta questão. Como é demonstrado, verifica-se que esta compatibilização está condicionada à, dentre alguns elementos, à participação política das sociedades, uma vez que sua revisão poderia ser um caminho para se repensar as lógicas hierárquicas do capitalismo global e refletir acerca de uma justiça ambiental.
OS CONSELHOS MUNICIPAIS DE MEIO AMBIENTE DAS CAPITAIS BRASILEIRAS E A PUBLICIDADE ON-LINE DAS SUAS AÇÕES PARA O ACOMPANHAMENTO SOCIAL
Authors: Branco André Oliveira Trigueiro Castelo , Gutierres Henrique Elias Pessoa
Published: August 2022

Os conselhos de meio ambiente foram criados para um maior controle social das ações e das decisões na área ambiental para um determinado território. O artigo tem o objetivo de avaliar o nível de implementação das práticas de transparência nos sites da internet dos conselhos municipais de meio ambiente das capitais brasileiras, que favoreçam a uma maior participação social na gestão ambiental municipal. Os dados foram obtidos através da análise de conteúdo dos endereços eletrônicos dos conselhos por meio do uso de uma Lista de Verificação (Checklist), que avaliou o nível de acesso público aos dados e informações inerentes aos conselhos. Foram elaborados e aplicados 22 quesitos relacionados às práticas de transparência, divididos em três áreas temáticas: acesso à informação; funcionamento do conselho; e acompanhamento social. A partir da obtenção do nível de conformidade dos quesitos atendidos por cada conselho, procedeu-se a uma correlação com três indicadores socioeconômicos: tamanho da população, Produto Interno Bruto – PIB e o Índice de Desenvolvimento Humano Municipal (IDHM), que permitem uma análise geográfica mais aprofundada. A relação entre o nível alto de atendimento dos quesitos aplicados e os maiores valores dos três indicadores socioeconômicos, não apresentou relação direta, na maioria das capitais. Os resultados permitem afirmar que a maior parte dos conselhos municipais de meio ambiente das capitais brasileiras precisa avançar numa maior transparência das suas práticas, na disponibilização de informações e canais de comunicação com a população. É fundamental que a participação seja estimulada nos conselhos, para que a sociedade seja sensibilizada, informada e empoderada a participar das soluções para as questões ambientais em nível local.
PROBABILIDADE DE OCORRÊNCIA DE TEMPERATURAS MÁXIMAS MENSAIS PREJUDICIAIS E FAVORÁVEIS AOS CULTIVOS AGRÍCOLAS EM MINAS GERAIS
Authors: Borges Rodrigo de Morais , Cargnelutti Filho Alberto , Loro Murilo Vieira
Published: August 2022

Os objetivos deste trabalho foram verificar o ajuste de séries temporais de temperatura máxima mensal do ar (Tmax), de 47 municípios de Minas Gerais, às funções de distribuições de probabilidade normal, log-normal, gama e weibull; determinar, para cada série temporal, o valor de Tmax cuja probabilidade de ocorrência de Tmax maior ou igual a esse valor é de 90%; e elaborar mapas com isolinhas. Nas 564 séries de dados (47 municípios × 12 meses) de Tmax aplicou-se o teste de aderência de Kolmogorov-Smirnov e determinou-se o valor de Tmax cuja probabilidade de ocorrência de Tmax maior ou igual a esse valor é de 90%. Os dados de Tmax se ajustam às distribuições normal, log-normal, gama e weibull. As estimativas dos parâmetros da distribuição normal (média e desvio padrão) podem ser utilizadas para determinar o valor de Tmax cuja probabilidade de ocorrência de Tmax maior ou igual a esse valor é de 90% e, para posterior elaboração de mapas com a interpolação desses valores de Tmax em isolinhas. As isolinhas são úteis para verificar a probabilidade de ocorrência de Tmax prejudicial ou favorável para culturas agrícolas.
FRONTEIRA TERRITORIAL E ZONA FRANCA DE CODEVI:
Authors: Sainte Guerby
Published: August 2022

Este trabalho tem como objetivo realizar uma discussão sobre a fronteira territorial e Zona Franca de CODEVI, tendo como foco as interações espaciais nas cidades-gêmeas de Ouanaminthe (Haiti) e Dajabón (República Dominicana). Partindo-se de um raciocínio de que tais interações entre as duas cidades constituem uma dinâmica econômica e comercial importante para a formação territorial nas escalas nacionais de cada país. Nessa perspectiva, a maioria das pesquisas mostra que as atividades da zona franca são muito deficientes na atribuição de alcançar causalidade na produção de dados, quer dizer, não possibilitam concluir que a chegada da zona franca de CODEVI garantiu impactos socioeconômicos nas regiões, fortalecendo a construção de redes de circulação de mercadoria nas regiões transfronteiras. Ao se investigar também como o Mercado transfronteiriço contribui para a reconfiguração territorial através das interações espaciais, também se revitaliza a visão da geografia ao trazer uma maior relevância ao território por meio da dinâmica de usos de circuitos da economia urbana ligados ao processo de desenvolvimento da economia de Ouanaminthe, impactando a evolução comercial com o mercado binacional.
Philosophie des Leidens
Authors: Wandruszka Boris
Published: August 2022

Die „Philosophie des Leidens“ stellt den Versuch dar, das Phänomen „Leiden“ in seiner ontologischen und existenzialen Grundstruktur aufzudecken. Dabei geht der Autor von konkreten, auch eigenen Leiderfahrungen aus und unterzieht sie einer phänomenologischen Analyse. Als universale Struktur enthüllt er eine dynamische Diskrepanzstruktur, in der sich pathische Betroffenheit und subjektive Stellungnahme eng verflechten. Dieser innere Widerspruch wird als Schmerz und Last erlebt: Der leidende Mensch erfährt und erleidet etwas, was er nicht erleiden will, aber erleiden muss. In jedem Leiden walten darum Befangenheit und Aufbegehren. Diesen Kern des Leidens legt der Autor aus, indem er zum einen das Leiden bis in seine letzten, fundamentalsten Strukturmomente verfolgt, zum anderen den Zusammenhang des Leidens mit allen Lebenskräften und Lebensbereichen aufzudecken sucht, so z.B. die Zusammenhänge zwischen Leiden und Erkenntnis, Gefühl oder Leib. Im Leiden erfährt sich der Mensch als begrenzt, bedrängt und gebunden, aber wäre er total unfrei, könnte er nur passiv erleiden (wie ein Stein einen Stoß erleidet), er könnte nicht leiden, d.h. sich innerlich in der Weise des Schmerzes erfahren. Leiden ist immer auch Selbstbewegung, ja - wenn auch meist unbewusste - Stellungnahme, in der ein Selbst-Welt-Konzept zum Austrag kommt. Damit ist klar, dass alles Leiden ein „Anderes“ impliziert, mit dem im Leiden kommuniziert wird. Am Ende seiner Arbeit verortet der Autor die „Philosophie des Leidens“ im Kanon der Wissenschaften und gibt einen Ausblick auf transphänomenale, „metaphysische“ Hintergründe des Leidens.
Religionsvergleich
Authors: Freiberger Oliver
Published: August 2022

How are Muslim concepts of God different from Christian or Hindu ones? What do they have in common? Comparing religious concepts, practices and objects is an everyday operation in religious studies research. But some comparative studies, especially cross-cultural ones, have also raised fundamental doubts about the method’s value. This book introduces the history, theory and practice of making comparisons in the study of religion. It discusses major approaches, addresses challenges and criticism, and demonstrates how today’s religious studies scholars can make comparisons productively and responsibly. The book is designed as a basic textbook for a one-semester course on the topic.
Nachdenken hilft
Authors: Söhner Felicitas , Becker Thomas , Seidel Ralf
Published: August 2022

Nachdenken hilft!

Auch beim Gespräch mit der nachfolgenden Generation über die Bedeutung der Vergangenheit und die Einordung des Erlebten.

Ralf Seidel war über 20 Jahre Ärztlicher Direktor der Landesklinik Mönchengladbach. Bei Beginn seiner Arbeit als Psychiater hatte die Sachverständigenkommission für die Psychiatrie-Enquete gerade ihren ersten Zwischenbericht an den Bundestag übergeben. Ralf Seidel hat die Psychiatriereform in Deutschland nicht nur miterlebt, sondern auch mitgeprägt.

Seine Interessen gingen dabei immer über sein Fach hinaus. Ralf Seidel hat nicht nur Medizin studiert, sondern auch Philosophie; er ist der Kunst sehr verbunden und weit gereist.

Ein ungewöhnliches Arztleben zwischen Aufbruch, Reform und Reflexion.
Application Overview of Quantum Computing for Gas Turbine Design and Optimization
Authors: Thomas Jayachandran Aurthur Vimalachandran
Published: August 2022

Conceptual designs require optimization methods to identify the best fit in the system. The article investigates the application of quantum computation in gas turbine design and simulation problems with current technologies, approaches and potential capabilities. Quantum optimization algorithms and quantum annealers help in predicting overall efficiency and optimizing various operating parameters of the gas turbine. A comparison of both classical and quantum computers has been discussed briefly. The classical model challenges are mitigated with the use of quantum computation. A novel hybrid model for simulating gas turbines has been proposed, which consists of a combination of both physics and machine learning to eliminate few of the critical problems faced. This review elaborates application of quantum computing based machine learning for design and optimization of a gas turbine. The overall states of the gas paths of gas turbines could be analyzed using the quantum computing model in the future.
Characterization of High-Temperature Tensile Properties and Thermal Stability in Gas Tungsten Arc Welds of Ti-added Reduced Activation Ferritic/Martensitic Steel
Authors: Jo Yoon-Hwan , Kim Tae-Hun , Kim Chiwon , Moon Joonoh , Lee Chang-Hoon , Jung Seung-Jin , Hong Hyun-Uk
Published: August 2022

In this study, the effects of Ti addition on the microstructure, the tensile properties at 550 ℃, and the thermal stability in gas tungsten arc (GTA) welds of reduced activation ferritic/martensitic (RAFM) steel were studied. Ti was added to promote precipitation of MX in order to enhance high-temperature properties. For reference, Ti-free RAFM (reference RAFM steel with the composition of 9Cr-1W-0.2V-0.1Ta-0.1C) was compared with 0.013 wt% Ti added RAFM steel (Ti-added RAFM). The addition of Ti contributed to the increase in the area fraction of MX precipitates (2.0 → 4.6 %) and a decrease in the average size of M23C6 (149 → 119 nm) in the base metal. After the cross-weld tensile test at 550 ℃, the tensile properties of Ti-added RAFM steel were superior to that of Ti-free RAFM steel. Both steels were fractured at inter-critical heat-affected zone (ICHAZ) showing the lowest hardness due to over-tempering. However, the higher area fraction of MX precipitates in the Ti-added RAFM produced more significant strengthening, compared to the Ti-free RAFM steel. After heat exposure at 550 ℃ for 500 h, Ti-added RAFM steel was highly resistant to degradation; hardness distribution and tensile properties were almost similar before and after thermal exposure. ICHAZ exhibited the substantial retention of fine laths and high density of dislocation with marginal recovery even after thermal exposure. It is conceivable that excellent thermal stability of Ti-added RAFM steel can be attributed to the high fraction of MX particles by suppressing lath boundary migration.
One Way of Being Ambiguous
Authors: Ansari Rosabel , McGinnis Jon ,   Philosophy Documentation Center
Published: August 2022

This study provides the historical background to, and analysis and translations of, two seminal texts from the medieval Islamic world concerning the univocity of being/existence and a theory of “ambiguous predication” (tashkīk), which is similar to the Thomistic theory of analogy. The disputants are Fakhr al-Dīn al-Rāzī (1149–1210), who defended a theory of the univocity of being, and Naṣīr al-Dīn al-Ṭūsī (1201–1274), who defended the theory of ambiguous predication. While the purported issue is whether a quiddity can cause its own existence, the debate extends further. Rāzī draws on several arguments that “existence” must be predicated univocally of God and creature and then concludes that, given the univocity of “existence,” God cannot be simple, but is a composite of the divine quiddity and distinct attributes. In contrast, Ṭūsī denies that “existence” is said univocally of God and creature and rather is predicated ambiguously/analogously, and then defends divine simplicity.
Scotus and Grosseteste on Phantasms and Illumination
Authors: Smith Brett W. ,   Philosophy Documentation Center
Published: August 2022

This article examines the reception of Robert Grosseteste by John Duns Scotus on two related questions in epistemology. The first concerns the need of phantasms for cognition, and the second concerns divine illumination. The study first examines Scotus’s Questions on the De Anima with comparison to Grosseteste’s Commentary on the Posterior Analytics, a text Scotus cites specifically. It is argued that Grosseteste is the main influence behind Scotus’s opinion that the need for phantasms is not proper to human nature as such. The second part shows how Scotus disagrees with Grosseteste on a related question. Grosseteste retains a version of divine illumination with a qualified need for phantasms, whereas Scotus maintains the strict necessity of phantasms in this life and rejects illumination. The two parts of this study taken together indicate that Scotus saw Grosseteste as an authority but also felt free to ignore him where the two disagreed.
Epidemics in Serbia during the wars 1912-1918.: Contribution to victim quantification
Authors: Krivošejev Vladimir
Published: August 2022

The aim of this paper is to point out the part of different epidemics in the reduction of population in Serbia during the First and Second Balkan Wars (1912 - 1913) and the First World War (1914 - 1918). In addition to suffering on the battlefield, the war conditions of life also led to the culmination of various diseases and the appearance of various major and minor, local, regional and world epidemics. By comparing data from the 1910-1913 census and in 1921 there was a population reduction of 526,430. (4,393,315: 3,866,885). Various infectious diseases took significantly more lives than all other causes combined, including war. According to accepted estimates, during the war years, infectious diseases took about 360,000 lives. The typhus epidemic, which affected the whole of Serbia during the first half of 1915, took about 135,000 lives. This paper is largely based on the analysis of church registers of the dead, and it points out several different local epidemics that affected the Serbian army and civilian population during the war years with great mortal consequences which took about 110,000 lives. These epidemics appeared during the all war years, associated or not associated with each other, and in different territories. These epidemics were: cholera, smallpox, diphtheria, dysentery, scarlet fever, whooping cough, etc.
Mutesellim of Novi Pazar Yusuf Bey, Serbs and Tanzimat (1838-1851)
Authors: Savić Aleksandar
Published: August 2022

The paper pays attention to the mutesellim of Novi Pazar Yusuf Bey (1838-1839, 1841-1842, 1842-1851), the Serbian people and the reflection of the Tanzimat reforms in the territory under his control - Novi Pazar, Mitrovica, Sjenica, Nova Varoš, Trgovište and Bihor kaza. It is pointed out that Yusuf Bey in the period 1838-1842. fought for the position of Novi Pazar mutesellim and that his administration ended in 1851, after the successful military action of the Rumelia serasker Omer Pasha Latas in the Bosnian Eyalet. In the mentioned year, the Sanjak of Novi Pazar was officially formed, which, in addition to the kazas that were under the control of Yusuf Bey, also included the Višegrad kaza. During the rule of Yusuf Bey, Serbs were exposed to constant violence, except in the period from 1844 to 1848, when a relatively peaceful situation prevailed. Serbs most complained about the representatives of the executive power who committed all kinds of violence (rapes, attempted violent islamization, murders).
Paracetamol overdosing with 6500 mg single dose: Case report
Authors: Murthy Shiva , Kumar Anil
Published: August 2022

Introduction: Paracetamol is available as a fixed dose combination with many non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen, Diclofenac, Mefenamic acid, Aceclofenac etc. On the other hand, it is also considered as the most common cause of overdosing and poisoning. Paracetamol can be purchased both by prescription or as an OTC medicine. Case report: This paper represents a case of a male, age 27, vegetarian, who does regular exercise, alcoholic, who self-overdosed with 6500 mg (~10 tablets of 650 mg each) of Paracetamol with suicidal intention. An attempt has been made to discuss the effects of Paracetamol on liver, kidney and other organs function through hematology, biochemistry, urine investigations done within 24 hours and day 7 after overdosing. Results of additional investigations such as liver function tests done on day 4 and day 5, X-ray chest, ultrasound scan of the abdomen and ECG done on day 1 were also included for discussion. Liver parameters were checked for presence of Drug Induced Liver Injury (DILI) using an algorithm published by Pineda S L et al. Conclusion: Results of this case analysis suggested the presence of mild DILI with a single dose of 6500 mg Paracetamol. We recommend further studies using algorithm of Pineda S L et al to assess the minimum doses that are expected to cause clinically significant DILI and recommend policies to drug regulators of the country to restrict the maximum number of doses that can be sold to the general public on OTC basis.
Design, implementation and experimental testing of a hybrid power supply of remote measuring station in the Surveillance, Alert & Warning System (SAWS)
Authors: Despotović Željko , Tajdić Marko
Published: August 2022

The paper presents the design, implementation and experimental testing of a hybrid power supply of telecommunication and measuring equipment incorporated in remote measuring stations, which are an integral part of the global Surveillance, Alert & Warning System (SAWS) in the Republic of Serbia. In these systems, it is very important to provide autonomy of permanent, reliable and quality power supply. In this case, the power supply system is in effect based on the use of solar energy i.e., photovoltaic (PV), in combination with the mains power supply 230V, 50Hz. Solar power is the primary source of power during the day, while in night conditions the secondary power supply is a distribution power grid (more precisely, the distribution power which is used for supplying the night street lighting). This hybrid power system is realized with two controlled chargers (MPPT solar and mains with input power factor correction), battery bank 12V/110Ah with the corresponding system for its monitoring and secondary DC/DC power converters for supplying telecommunication and measuring electronic modules. The key implementation and experimental results obtained during the realization of a SAWS remote measuring station on the river Ub (municipality of Ub), will be presented in the paper.
Compact two-position phase shifter
Authors: Letavin Denis
Published: August 2022

The paper proposes and investigates the topology of a phase shifter based on a directional coupler. The dimensions of such a device are reduced by using artificial transmission lines instead of quarter-wave sections. By connecting several pairs of phase-shifting cells instead of the usual one, it was possible to obtain a phase shifter design with two phase shifts (instead of one).
Assessing the Impact of Transportation Infrastructure on Rural Residents' Income: Using the Quantile Regression Approach
Authors: Xu Bin
Published: August 2022

The impact of transportation infrastructure on farmers’ income has been the focus of attention by government managers and related scholars in recent years. Based on the panel data from 2000 to 2018, this paper uses the quantile regression model to explore the effect of highway and railway transportation infrastructures on wage income and operating income. The findings show that the highway transportation infrastructure makes a minimal contribution to the wage income in Shanghai, Beijing and Zhejiang provinces, because the highway mileage and highway passenger turnover in these provinces are small. However, the operating income in the upper 90th quantile provinces such as Jilin, Heilongjiang, and Zhejiang, receives the biggest impact from the highway transportation infrastructure, because the construction of rural roads in these provinces is growing faster. The impact of railway transportation infrastructure on the wage income in the 10th-25th, 25th-50th and 50th-75th quantile provinces is small, since their railway passenger turnover is less. The railway transportation infrastructure has not played a role in boosting the operating income in these provinces such as Guizhou, Shaanxi, Gansu, Shanxi, Qinghai, and Ningxia. Therefore, each quantile province should formulate specific policies to promote the construction of transportation infrastructure.
Conceptualising Refugee Girls’ Perspectives on Education, Child Marriage and Life in Lebanon, Australia and Sweden
Authors: Maadad Nina , Yu Marizon
Published: August 2022

This article explores the education experiences of Syrian and Iraqi refugee children, specifically girls, enrolled in high schools in Australia, Lebanon and Sweden. Symbolic interactionism frames the analysis of in-depth interviews, demonstrating the adolescent girls’ ability
to take perspectives on their home environment, school, community and life experiences. Influenced by socialisation to these environments, the article asserts that refugee girls have defined their situations, developed their own personal perspectives and adjusted their behaviour in line with
others. Additionally, this paper reinforces the analytical framework regarding refugee girls’ schooling experiences through critical pedagogy by recognising the nature of their educational disadvantage.
Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia
Authors: Montgomery Sean Akira , Hisanaga Tetsuya , Wang Nan , Axelsson Elin , Akimcheva Svetlana , Sramek Milos , Liu Chang , Berger Frédéric
Published: August 2022

Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling gene dosage have been extensively studied in animals, however it is unknown how generalizable these mechanisms are to diverse eukaryotes. Here, we use the haploid plant Marchantia polymorpha to assess gene dosage control in its short-lived diploid embryo. We show that throughout embryogenesis, paternal chromosomes are repressed resulting in functional haploidy. The paternal genome is targeted for genomic imprinting by the Polycomb mark H3K27me3 starting at fertilization, rendering the maternal genome in control of embryogenesis. Maintaining haploid gene dosage by this new form of imprinting is essential for embryonic development. Our findings illustrate how haploid-dominant species can regulate gene dosage through paternal chromosome inactivation and initiates the exploration of the link between life cycle history and gene dosage in a broader range of organisms.
Nuclear fascin regulates cancer cell survival
Authors: Lawson Campbell D , Peel Samantha , Jayo Asier , Corrigan Adam , Iyer Preeti , Baxter Dalrymple Mabel , Marsh Richard J , Cox Susan , Van Audenhove Isabel , Gettemans Jan , Parsons Maddy
Published: August 2022

Fascin is an important regulator of F-actin bundling leading to enhanced filopodia assembly. Fascin is also overexpressed in most solid tumours where it supports invasion through control of F-actin structures at the periphery and nuclear envelope. Recently, fascin has been identified in the nucleus of a broad range of cell types but the contributions of nuclear fascin to cancer cell behaviour remain unknown. Here, we demonstrate that fascin bundles F-actin within the nucleus to support chromatin organisation and efficient DDR. Fascin associates directly with phosphorylated Histone H3 leading to regulated levels of nuclear fascin to support these phenotypes. Forcing nuclear fascin accumulation through the expression of nuclear-targeted fascin-specific nanobodies or inhibition of Histone H3 kinases results in enhanced and sustained nuclear F-actin bundling leading to reduced invasion, viability, and nuclear fascin-specific/driven apoptosis. These findings represent an additional important route through which fascin can support tumourigenesis and provide insight into potential pathways for targeted fascin-dependent cancer cell killing.
β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel
Authors: Foster Hannah R , Ho Thuong , Potapenko Evgeniy , Sdao Sophia M , Huang Shih Ming , Lewandowski Sophie L , VanDeusen Halena R , Davidson Shawn M , Cardone Rebecca L , Prentki Marc , Kibbey Richard G , Merrins Matthew J
Published: August 2022

Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP carboxykinase (PCK2) that generates mitochondrial PEP. Glucose metabolism was found to generate both glycolytic and mitochondrially derived PEP, which triggers KATP closure through local PKm1 and PKm2 signaling at the plasma membrane. Amino acids, which generate mitochondrial PEP without producing glycolytic fructose 1,6-bisphosphate to allosterically activate PKm2, signal through PKm1 to raise ATP/ADP, close KATP channels, and stimulate insulin secretion. Raising cytosolic ATP/ADP with amino acids is insufficient to close KATP channels in the absence of PK activity or PCK2, indicating that KATP channels are primarily regulated by PEP that provides ATP via plasma membrane-associated PK, rather than mitochondrially derived ATP. Following membrane depolarization, the PEP cycle is involved in an ‘off-switch’ that facilitates KATP channel reopening and Ca2+ extrusion, as shown by PK activation experiments and β-cell PCK2 deletion, which prolongs Ca2+ oscillations and increases insulin secretion. In conclusion, the differential response of PKm1 and PKm2 to the glycolytic and mitochondrial sources of PEP influences the β-cell nutrient response, and controls the oscillatory cycle regulating insulin secretion.
Identification of putative enhancer-like elements predicts regulatory networks active in planarian adult stem cells
Authors: Neiro Jakke , Sridhar Divya , Dattani Anish , Aboobaker Aziz
Published: August 2022

Planarians have become an established model system to study regeneration and stem cells, but the regulatory elements in the genome remain almost entirely undescribed. Here, by integrating epigenetic and expression data we use multiple sources of evidence to predict enhancer elements active in the adult stem cell populations that drive regeneration. We have used ChIP-seq data to identify genomic regions with histone modifications consistent with enhancer activity, and ATAC-seq data to identify accessible chromatin. Overlapping these signals allowed for the identification of a set of high-confidence candidate enhancers predicted to be active in planarian adult stem cells. These enhancers are enriched for predicted transcription factor (TF) binding sites for TFs and TF families expressed in planarian adult stem cells. Footprinting analyses provided further evidence that these potential TF binding sites are likely to be occupied in adult stem cells. We integrated these analyses to build testable hypotheses for the regulatory function of TFs in stem cells, both with respect to how pluripotency might be regulated, and to how lineage differentiation programs are controlled. We found that our predicted GRNs were independently supported by existing TF RNAi/RNA-seq datasets, providing further evidence that our work predicts active enhancers that regulate adult stem cells and regenerative mechanisms.
Automated systematic evaluation of cryo-EM specimens with SmartScope
Authors: Bouvette Jonathan , Huang Qinwen , Riccio Amanda A , Copeland William C , Bartesaghi Alberto , Borgnia Mario J
Published: August 2022

Finding the conditions to stabilize a macromolecular target for imaging remains the most critical barrier to determining its structure by cryo-electron microscopy (cryo-EM). While automation has significantly increased the speed of data collection, specimens are still screened manually, a laborious and subjective task that often determines the success of a project. Here, we present SmartScope, the first framework to streamline, standardize, and automate specimen evaluation in cryo-EM. SmartScope employs deep-learning-based object detection to identify and classify features suitable for imaging, allowing it to perform thorough specimen screening in a fully automated manner. A web interface provides remote control over the automated operation of the microscope in real time and access to images and annotation tools. Manual annotations can be used to re-train the feature recognition models, leading to improvements in performance. Our automated tool for systematic evaluation of specimens streamlines structure determination and lowers the barrier of adoption for cryo-EM.
Chemistry, taxonomy and ecology of the potentially chimpanzee-dispersed Vepris teva sp.nov. (Rutaceae) endangered in coastal thicket in the Congo Republic
Authors: Langat Moses K. , Kami Teva , Cheek Martin
Published: August 2022

Continuing a survey of the chemistry of species of the largely continental African genus Vepris, we investigate a species previously referred to as Vepris sp. 1 of Congo. From the leaves of Vepris sp. 1 we report six compounds. The compounds were three furoquinoline alkaloids, kokusaginine (1), maculine (2), and flindersiamine (3), two acridone alkaloids, arborinine (4) and 1-hydroxy-3-methoxy-10-methylacridone (5), and the triterpenoid, ß-amyrin (6). Compounds 1–4 are commonly isolated from other Vepris species, compound 5 has been reported before once, from Malagasy Vepris pilosa, while this is the first report of ß-amyrin from Vepris. This combination of compounds has never before been reported from any species of Vepris. We test the hypothesis that Vepris sp. 1 is new to science and formally describe it as Vepris teva, unique in the genus in that the trifoliolate leaves are subsessile, with the median petiolule far exceeding the petiole in length. Similar fleshy-leathery four-locular syncarpous fruits are otherwise only known in the genus in Vepris glaberrima (formerly the monotypic genus Oriciopsis Engl.), a potential sister species, but requiring further investigation to confirm this phylogenetic position. We briefly characterise the unusual and poorly documented Atlantic coast equatorial ecosystem, where Vepris teva is restricted to evergreen thicket on white sand, unusual in a genus usually confined to evergreen forest. This endemic-rich ecosystem with a unique amphibian as well as plants, extends along the coastline from the mouth of the Congo River to southern Rio Muni, a distance of about 1,000 km, traversing five countries. We map and illustrate Vepris teva and assess its extinction risk as Endangered (EN B1ab(iii)+B2ab(iii)) using the IUCN, 2012 standard. Only three locations are known, and threats include port and oil refinery construction and associated activities, with only one protected location, the Jane Goodall Institute’s Tchimpounga Reserve. Initial evidence indicates that the seeds of Vepris teva are dispersed by chimpanzees, previously unreported in the genus.