bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-time dense-view imaging for three-dimensional light-field display based on image color calibration and self-supervised view synthesis
Authors: Guo Xiao , Sang Xinzhu , Yan Binbin , Wang Huachun , Ye Xiaoqian , Chen Shuo , Wan Huaming , Li Ningchi , Zeng Zhehao , Chen Duo , Wang Peng , Xing Shujun
Published: May 2022

Three-Dimensional (3D) light-field display has achieved promising improvement in recent years. However, since the dense-view images cannot be collected fast in real-world 3D scenes, the real-time 3D light-field display is still challenging to achieve in real scenes, especially at the high-resolution 3D display. Here, a real-time 3D light-field display method with dense-view is proposed based on image color correction and self-supervised optical flow estimation, and a high-quality and high frame rate of 3D light-field display can be realized simultaneously. A sparse camera array is firstly used to capture sparse-view images in the proposed method. To eliminate the color deviation of the sparse views, the imaging process of the camera is analyzed, and a practical multi-layer perception (MLP) network is proposed to perform color calibration. Given sparse views with consistent color, the optical flow can be estimated by a lightweight convolutional neural network (CNN) at high speed, which uses the input image pairs to learn the optical flow in a self-supervised manner. With inverse warp operation, dense-view images can be synthesized in the end. Quantitative and qualitative experiments are performed to evaluate the feasibility of the proposed method. Experimental results show that over 60 dense-view images at a resolution of 1024 × 512 can be generated with 11 input views at a frame rate over 20 fps, which is 4× faster than previous optical flow estimation methods PWC-Net and LiteFlowNet3. Finally, large viewing angles and high-quality 3D light-field display at 3840 × 2160 resolution can be achieved in real-time.
Designing optimal allocations for cancer screening using queuing network models
Authors: Dean Justin , Goldberg Evan , Michor Franziska
Published: May 2022

Cancer is one of the leading causes of death, but mortality can be reduced by detecting tumors earlier so that treatment is initiated at a less aggressive stage. The tradeoff between costs associated with screening and its benefit makes the decision of whom to screen and when a challenge. To enable comparisons across screening strategies for any cancer type, we demonstrate a mathematical modeling platform based on the theory of queuing networks designed for quantifying the benefits of screening strategies. Our methodology can be used to design optimal screening protocols and to estimate their benefits for specific patient populations. Our method is amenable to exact analysis, thus circumventing the need for simulations, and is capable of exactly quantifying outcomes given variability in the age of diagnosis, rate of progression, and screening sensitivity and intervention outcomes. We demonstrate the power of this methodology by applying it to data from the Surveillance, Epidemiology and End Results (SEER) program. Our approach estimates the benefits that various novel screening programs would confer to different patient populations, thus enabling us to formulate an optimal screening allocation and quantify its potential effects for any cancer type and intervention.
Evaluation of spatial Bayesian Empirical Likelihood models in analysis of small area data
Authors: Jahan Farzana , Kennedy Daniel W. , Duncan Earl W. , Mengersen Kerrie L.
Published: May 2022

Bayesian empirical likelihood (BEL) models are becoming increasingly popular as an attractive alternative to fully parametric models. However, they have only recently been applied to spatial data analysis for small area estimation. This study considers the development of spatial BEL models using two popular conditional autoregressive (CAR) priors, namely BYM and Leroux priors. The performance of the proposed models is compared with their parametric counterparts and with existing spatial BEL models using independent Gaussian priors and generalised Moran basis priors. The models are applied to two benchmark spatial datasets, simulation study and COVID-19 data. The results indicate promising opportunities for these models to capture new insights into spatial data. Specifically, the spatial BEL models outperform the parametric spatial models when the underlying distributional assumptions of data appear to be violated.
Measuring user interactions with websites: A comparison of two industry standard analytics approaches using data of 86 websites
Authors: Jansen Bernard J. , Jung Soon-gyo , Salminen Joni
Published: May 2022

This research compares four standard analytics metrics from Google Analytics with SimilarWeb using one year’s average monthly data for 86 websites from 26 countries and 19 industry verticals. The results show statistically significant differences between the two services for total visits, unique visitors, bounce rates, and average session duration. Using Google Analytics as the baseline, SimilarWeb average values were 19.4% lower for total visits, 38.7% lower for unique visitors, 25.2% higher for bounce rate, and 56.2% higher for session duration. The website rankings between SimilarWeb and Google Analytics for all metrics are significantly correlated, especially for total visits and unique visitors. The accuracy/inaccuracy of the metrics from both services is discussed from the vantage of the data collection methods employed. In the absence of a gold standard, combining the two services is a reasonable approach, with Google Analytics for onsite and SimilarWeb for network metrics. Finally, the differences between SimilarWeb and Google Analytics measures are systematic, so with Google Analytics metrics from a known site, one can reasonably generate the Google Analytics metrics for related sites based on the SimilarWeb values. The implications are that SimilarWeb provides conservative analytics in terms of visits and visitors relative to those of Google Analytics, and both tools can be utilized in a complementary fashion in situations where site analytics is not available for competitive intelligence and benchmarking analysis.
High phosphate intake induces bone loss in nephrectomized thalassemic mice
Authors: Wanna-udom Sasithorn , Luesiripong Chainarong , Sakunrangsit Nithidol , Metheepakornchai Piyanuch , Intharamonthian Sitthichai , Svasti Saovaros , Greenblatt Matthew B. , Leelahavanichkul Asada , Lotinun Sutada
Published: May 2022

Although patients with either β-thalassemia or chronic kidney disease (CKD) clinically correlate with severe osteoporosis, the mechanism by which CKD exposed to high phosphate affects bone turnover has not been characterized in β-thalassemia. We aimed to determine the effects of renal insufficiency on high phosphate intake induced changes in bone metabolism after 5/6thnephrectomy in hemizygousβ-globinknockout (BKO) mice. Male BKO mice manifested severe anemia and osteopenia. Nephrectomy induced renal fibrosis and reduced renal function as assessed by increased serum urea nitrogen levels. Moreover, nephrectomy increased bone turnover leading to bone loss in wild type (WT) but not BKO mice. In nephrectomized BKO, PBS in drinking water induced hyperphosphatemia, and hypercalcemia along with osteopenia in both cancellous and cortical bone. Histomorphometric analysis confirmed reduced cancellous bone volume due to decreased bone formation rate, osteoblast number and osteoclast number. The mRNA levels forAlpl,Sp7,Kl,Tnfsf11, andTnfsf11/Tnfrsf11bwere decreased in nephrectomized BKO mice drinking PBS. Interestingly,Fgf23, a bone-derived hormone produced by osteocytes and osteoblasts in response to hyperphosphatemia, were remarkably increased in nephrectomized BKO mice following PBS intake. Serum FGF23 and erythropoietin levels were markedly elevated in BKO mice. Nephrectomy decreased serum erythropoietin but not FGF23 levels. Hyperphosphatemia in BKO mice increased serum erythropoietin, FGF23, and PTH levels, nominating these factors as candidate mediators of bone loss in thalassemic mice with CKD during phosphate retention.
Exploring interprofessional identity development in healthcare graduates and its impact on practice
Authors: Tong Ruyi , Brewer Margo , Flavell Helen , Roberts Lynne
Published: May 2022

Interprofessional identity development is an emerging area of research. Whilst there is a growing body of studies exploring interprofessional identity development and interprofessional education, little is known about interprofessional identity development in healthcare professionals and the impact of interprofessional identity on practice. This study explored interprofessional identity development in graduates during their first year of work as health professionals and the influence of this on practice. All graduates had prior interprofessional education as students. Fourteen interviews with eight graduates were conducted. Data was analysed cross-sectionally using inductive thematic analysis. Three inter-related themes were developed: ‘growing confidence,’ ‘commitment to client-centred care,’ and ‘maintaining dual identification in different contexts.’ These themes demonstrated that, first, interprofessional identity development occurred along a continuum influenced by the practice context and the individual’s commitment to client-centred care. Second, confidence identifying and practising as a healthcare professional facilitates further interprofessional identity development. Third, maintaining identification as an interprofessional practitioner involves developing an increasingly sophisticated understanding of interprofessional practice by viewing interprofessional identity through increasingly complex meaning-making lenses consistent with the constructive developmental theory of self. Findings support the inclusion of pre-licensure interprofessional education and inform further interprofessional identity research in professionals beyond their first year of practice.
Magnetic fields induce exclusion zones in water
Authors: Shalatonin Valery , Pollack Gerald H.
Published: May 2022

Hydrophilic materials immersed in aqueous solutions show near-surface zones that exclude suspended colloids and dissolved molecules. These exclusion zones (EZs) can extend for tens to hundreds of micrometers from hydrophilic surfaces and show physicochemical properties that differ from bulk water. Here we report that exposure of standard aqueous microsphere suspensions to static magnetic fields creates similar microsphere-free zones adjacent to magnetic poles. The EZs build next to both north and south poles; and they build whether the microspheres are of polystyrene or carboxylate composition. EZ formation is accompanied by ordered motions of microspheres, creating dense zones some distance from the magnetic poles and leaving microsphere-free zones adjacent to the magnet. EZ size was larger next to the north pole than the south pole. The difference was statistically significant when polystyrene microspheres were used, although not when carboxylate microspheres were used. In many ways, including both size and dynamics, these exclusion zones resemble those found earlier next to various hydrophilic surfaces. The ability to create EZs represents a feature of magnets not previously revealed.
Heart rate recovery in 1 minute after the 6-minute walk test predicts adverse outcomes in pulmonary arterial hypertension
Authors: Rezende Camila Farnese , Mancuzo Eliane Viana , Corrêa Ricardo de Amorim
Published: May 2022

Heart rate recovery in 1 minute (HRR1) after the end of the 6-minute walk test (6MWT) is a non-invasive method of determining autonomic dysfunction. This parameter remains largely unexplored in pulmonary arterial hypertension (PAH) registries. We aimed to define the cut-off value and accuracy for abnormal HRR1 after the 6MWT and to investigate the association between HRR1 and clinical worsening in patients with PAH. This composite outcome was defined as first occurrence of all-cause death OR hospitalization from any cause OR disease progression characterized by decreased ≥ 15% in six-minute walking distance from baseline AND start of new specific PAH treatment or persistent worsening of World Health Organization functional class (WHO-FC). We performed a prospective cohort study that included 102 consecutive patients with PAH confirmed by right heart catheterization that underwent an 6MWT upon the diagnosis, recruited from September 2004 to April 2020 and followed up until April 2021 or death. The median HRR1 was 18 beats (IQR: 10–22), 50 and 52 PAH patients with <18 beats and ≥18 beats, respectively. The best cut-off for HRR1 to discriminate clinical worsening was 17 beats, with area under the curve (AUC) of 0.704 (95%CI: 0.584–0.824). The internal validation model by bootstrap showed an AUC of 0.676 (95%CI: 0.566–0.786) and the most accurate value was obtained in the seventh year of follow-up (AUC = 0.711; 95%CI: 0.596–0.844). Patients with an HRR1 <18 beats at baseline had a median event-free time of 2.17 years (95%CI: 1.82 to 2.52) versus 4.75 years (95%CI: 1.43 to 8.07) from those with ≥18 beats. In conclusion, a HRR1 value of less than 18 beats may be a reliable indicator of poor prognosis in patients with PAH.
Changing trends in ophthalmological emergencies during the COVID-19 pandemic
Authors: Escribano Villafruela José , de Urquía Cobo Antonio , Martín Luengo Fátima , Antón Modrego Víctor , Chamorro González-Cuevas María
Published: May 2022

On March 11, 2020, the World Health Organization declared COVID-19—the infectious disease caused by SARS-CoV-2—a pandemic. Since then, the majority of countries—including Spain—have imposed strict restrictions in order to stop the spread of the virus and the collapse of the health systems. People’s health care–seeking behavior has exhibited a change, not only in those months when the COVID-19 control measures were strictest, but also in the months that followed. We aimed to examine how the trends in ophthalmological emergencies changed during the COVID-19 pandemic in one of the largest tertiary referral hospitals in Spain. To this end, data from all the patients that attended the ophthalmological emergency department during the pandemic period—March 2020 to February 2021—were retrospectively collected and compared with data from the previous year. Moreover, a comparison between April 2020—when the restrictions were most severe—and April 2019 was made. A total of 90,694 patients were included. As expected, there was a decrease in the number of consultations. There was also a decrease in the frequency of conjunctival pathology consultations. These changes may bring to light not only the use that people make of the emergency department, but also the new trends in ophthalmological conditions derived from the hygienic habits that the COVID-19 pandemic has established.
Differences in PD-L1 Expression between oral and oropharyngeal squamous cell carcinoma
Authors: Blatt Sebastian , Krüger Maximilian , Rump Constantin , Zimmer Stefanie , Sagheb Keyvan , Künzel Julian
Published: May 2022

Treatment of metastasized or recurrent oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma remains challenging. Targeted antibody-based therapy inter alia for PD-1 / PD-L1 axis shows promising results, but whether PD-L1 expression varies between the subentities remains unclear. The expression pattern of PD-L1 (EPR19759 antibody, Abcam, Berlin, Germany) and p16 (CINtech® Histology Kit, Ventana, Oro Valley, USA) was determined immunohistochemically and analyzed by HALO™ Image Analysis Software (Indica Lab, Albuquerque, USA). For PD-L1, combined positivity score (CPS), tumor proportion score (TPS) and histoscore, were assessed and results correlated with epidemiological data. In total, 161 patients (OSCC: n = 78, OPSCC: n = 83) were included. A mean of 43.6% (±34.0%) of the specimen showed increased PD-L1 expression that did not differ quantitatively between subentities (TPS: p = 0.159, CPS: p = 0.078), but qualitatively (histoscore: p = 0.003). In the mean follow-up period (45.6 months), contrary to age (p = 0.006) and advanced T-Status (p = 0.018), PD-L1 expression did not correlate with overall (OS, p = 0.191) and recurrence free survival (RFS: p = 0.193) in both subentities. No correlation of p16 and PD-L1 expression was found (p = 0.844). PD-L1 is differentially expressed between OSCC and OPSCC, however without influence on OS. Furthermore, p16 status was not related to PD-L1 expression. This may have implications for future (immune) therapeutical approaches for oral cancer.
Cost drivers associated with diffuse large B-cell lymphoma (DLBCL) in Japan: A structural equation model (SEM) analysis
Authors: Tsutsué Saaya , Makita Shinichi , Yi Jingbo , Crawford Bruce
Published: May 2022

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin’s lymphoma of increasing prevalence in Japan. However, patients with relapsed or refractory disease to first line treatment (rrDLBCL) have been found to shoulder greater economic burden and have poor survival with subsequent lines of therapy. The relative impact of individual patient attributes on total medical cost among patients with rrDLBCL receiving second or third line (2L/3L) therapy was assessed. Structural equation modelling was used to identify potential cost drivers of total medical costs incurred by treatment and procedures in a Japanese retrospective claims database. From the database, rrDLBCL patients on 2L or 3L of treatment were grouped into respective cohorts. The mean [median] (SD) total medical cost of care for the 2L cohort was 73,296.40 [58,223.11] (58,409.79) US dollars (USD) and 75,238.35 [60,477.31] (59,583.66) USD for the 3L cohort. The largest total effect on medical cost in both cohorts was length of hospital stay (LOS) (β: 0.750 [95%CI: 0.728, 0.772] vs β: 0.762 [95%CI: 0.729, 0.794]). Length of hospital stay and potential heart disease complications due to line of treatment were the primary drivers of total cost for patients who had received at least 2L or 3L therapy for rrDLBCL.
The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments
Authors: Godlee Camilla , Cerny Ondrej , Liu Mei , Blundell Samkeliso , Gallagher Alanna E. , Shahin Meriam , Holden David W.
Published: May 2022

SteD is a transmembrane effector of the Salmonella SPI-2 type III secretion system that inhibits T cell activation by reducing the amounts of at least three proteins –major histocompatibility complex II (MHCII), CD86 and CD97 –from the surface of antigen-presenting cells. SteD specifically localises at the trans-Golgi network (TGN) and MHCII compartments; however, the targeting, membrane integration and trafficking of SteD are not understood. Using systematic mutagenesis, we identify distinct regions of SteD that are required for these processes. We show that SteD integrates into membranes of the ER/Golgi through a two-step mechanism of membrane recruitment from the cytoplasm followed by integration. SteD then migrates to and accumulates within the TGN. From here it hijacks the host adaptor protein (AP)1-mediated trafficking pathway from the TGN to MHCII compartments. AP1 binding and post-TGN trafficking require a short sequence in the N-terminal cytoplasmic tail of SteD that resembles the AP1-interacting dileucine sorting signal, but in inverted orientation, suggesting convergent evolution.
HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages
Authors: Han Mingyu , Cantaloube-Ferrieu Vincent , Xie Maorong , Armani-Tourret Marie , Woottum Marie , Pagès Jean-Christophe , Colin Philippe , Lagane Bernard , Benichou Serge
Published: May 2022

Macrophages (MΦ) are increasingly recognized as HIV-1 target cells involved in the pathogenesis and persistence of infection. Paradoxically,in vitroinfection assays suggest that virus isolates are mostly T-cell-tropic and rarely MΦ-tropic. The latter are assumed to emerge under CD4+ T-cell paucity in tissues such as the brain or at late stage when the CD4 T-cell count declines. However, assays to qualify HIV-1 tropism use cell-free viral particles and may not fully reflect the conditions ofin vivoMΦ infection through cell-to-cell viral transfer. Here, we investigated the capacity of viruses expressing primary envelope glycoproteins (Envs) with CCR5 and/or CXCR4 usage from different stages of infection, including transmitted/founder Envs, to infect MΦ by a cell-free mode and through cell-to-cell transfer from infected CD4+ T cells. The results show that most viruses were unable to enter MΦ as cell-free particles, in agreement with the current view that non-M-tropic viruses inefficiently use CD4 and/or CCR5 or CXCR4 entry receptors on MΦ. In contrast, all viruses could be effectively cell-to-cell transferred to MΦ from infected CD4+ T cells. We further showed that viral transfer proceeded through Env-dependent cell-cell fusion of infected T cells with MΦ targets, leading to the formation of productively infected multinucleated giant cells. Compared to cell-free infection, infected T-cell/MΦ contacts showed enhanced interactions of R5 M- and non-M-tropic Envs with CD4 and CCR5, resulting in a reduced dependence on receptor expression levels on MΦ for viral entry. Altogether, our results show that virus cell-to-cell transfer overcomes the entry block of isolates initially defined as non-macrophage-tropic, indicating that HIV-1 has a more prevalent tropism for MΦ than initially suggested. This sheds light into the role of this route of virus cell-to-cell transfer to MΦ in CD4+ T cell rich tissues for HIV-1 transmission, dissemination and formation of tissue viral reservoirs.
Instrument-based music theory on YouTube: Entries and barriers to lifelong learning
Authors: Schmidt-Jones Catherine
Published: May 2022

Many adults are motivated to learn about music independently; YouTube is a particularly popular resource. This study analysed YouTube searches, videos and viewer comments for evidence regarding the feasibility of learning music concepts through YouTube in the context of instruments that are popular among independent learners. It appeared that many such learners successfully use this resource, but multiple barriers to novice-level learning were also found. Music educators can help prepare students for lifelong learning by teaching independent use of online resources.
Ableton Live professional learning development for secondary school music teachers
Authors: Emo Martin
Published: May 2022

There is a gap between secondary school music teacher’s knowledge of digital audio workstations (DAWs) and the phenomena of the digital musician. A digital musician is a student who uses a computer as their primary instrument for composing and performing music. This case study of in-service professional learning development (PLD) was based on the DAW Ableton Live and its integrated hardware controller, the Push. A review of professional learning literature informed the blended learning design (BLD) approach of the study. The analysis used a six-phase inductive approach for interpretive analysis of the themes. Results of this pre-COVID-19 study revealed that time, BLD, facilitation and videos impacted on the learning of the participants. Additionally, the participants underwent two linked paradigm shifts: first to include a computer and DAW in their conception of what music-making could be, and second that Ableton Live and the Push were musical instruments. Findings suggest that future PLD could increase learner readiness for using videos and a BLD in addition to preparing them for a paradigm shift.
Science at the Club: Putrefaction as an artistic medium
Authors: Lartigue Angel
Published: May 2022

Science at the Club explores the architecture of the nightclub space as a nucleus for queer testimony, relating it to a judiciary courtroom. This performance challenges legal doctrines of forensic identification and the binary of life and death, by transforming biological and forensic material into ephemeral essences within the performance of the dance floor. Divided into a case study surrounding my performances at nightclubs, research courses taken in human remains recovery and visits to various burial sites of South Texas, I pull from a variety of interdisciplinary studies relating to queer death theory, building on José Esteban Muñoz’s notion of ‘disidentification’ in relation to the human corpse, racial politics in science and the biological arts in a nightclub context. Science at the Club creates a catalyst platform challenging racial and scientific histories of the body and land within the current US political climate, while exploring questions of resurrection and disintegration with a focus on the language of forensics and identity.
Offering the Body: Performing proximity in the use of cellular material
Authors: Mackenzie Louise
Published: May 2022

Cellular and sub-cellular material become creative medium across a range of disciplines that engage with biotechnology, from medicine to art practice. Historically, these practices complicated the boundaries of the body through patriarchal and colonial narratives of abstraction and extraction. In contrast to the ethical requirements of anonymity in medical research, this article suggests that material culture has a duty to know the body it works with. Three brief histories of bodily donation are recounted and aspects of these are contrasted with contemporary approaches to the use of bodily material within art practice. The developing project, Offering the Body, is offered as an example of performative practice that reintroduces a proximity to the body in biotechnological practices and begins to question whether through art practice, the biological body can move from commodity to be considered as a more-than-human resource.
Mooncalf: ‘Unclean meat’
Authors: Hunter WhiteFeather
Published: May 2022

The calamitous warnings of climate science have been latched onto by a growing roster of biotech start-up companies who propose to invent lab-generated meat alternatives to the ecologically disastrous livestock industry. They use solutionist hype to promote ‘sustainable’, ‘eco-friendly’, ‘cruelty-free’, ‘clean meat’. This moralized marketing, however, masks a continued reliance on animal agriculture. The fact remains that mammalian cells and tissues are grown in vitro using foetal calf serum, a blood-derived nutrient. Is it really possible to grow meat without banking on the bodies of nonhuman others? Might there be more tasteful material? In Bioart Kitchen: Art, Feminism and Technoscience, Lindsay Kelley asks, ‘[h]‌ow do technologies taste?’ This article proposes one answer to her prompt, centred on a technofeminist contextualization of the research-creation project, Mooncalf (2019–present). Mooncalf is a series of wet lab experiments and artistic outputs that showcase the potential viability of human menstrual serum for culturing mammalian tissue. These experiments present a direct provocation that problematizes the cellular agriculture industry as it pertains to the production of ‘clean meat’ and instead works towards a proof-of-concept ‘unclean’ meat prototype. Mooncalf is a symbolic precursor or speculative promise meant to facilitate a ‘cultural taste’ for feminist biotechnologies.
Taboo and capitalism: Of incest, YouTube and profanation in contemporary capitalism
Authors: Guardiola-Rius Adrià
Published: May 2022

Taboo, as a space where the prohibited resides, delimits the form of the thinkable in a society. Freud, in Totem and Taboo, attempted to trace an explanation beyond the ‘categorical imperative’ of morality and custom. A century later the YouTuber PrankInvasion (Chris Monroe) seems to continue Freud’s account to his advantage. Through ‘Kissing my actual sister prank’, one of his most controversial videos, he challenged his own followers to fulfil an especially controversial challenge: kiss his own stepsister. It is through these contacts with the limits of the moral, of the acceptable, that capitalism expands the colonized territory, absorbing the profane under its new exposure value. The unthinkable, the purported profanation of dogma (in this case, taboo of incest), disappears under the standardization of all rites as standardized consumable objects. But as Agamben warns about the nature of desecration it can not be related, in its new use, with the consumption realm. And that is not the case with PrankInvasion. Through the apparent absence of ordinary moral limits, Chris Monroe expresses his heartfelt attachment to the most extraordinary limit of capitalism: economic growth.
The gendered AI in Her (2013): Sound, synchresis and disconnection in filmic representations
Authors: Papakyriakopoulou Katerina
Published: May 2022

Motivated by the issues raised by the merging of women and machines in science fiction, this article explores gender representations in Spike film Her that discusses the interaction between a male human and a disembodied female whose consciousness is held in an artificial intelligence (AI) operating system. One of the primary questions regarding the representation of the female AI is whether the film encourages a feminist perspective, that promotes female subjectivity in the era of the post-human, or it ends up perpetuating visions of women’s oppression and objectification. Visual representations are important when discussing gender binaries, as they can be related to the image and the physical sexual differences. However, the role of sound is also crucial, as it contributes to different readings. In my analysis, I examine the merging and unmerging of audio and visual in the film. The female voice is the focal point of the analysis.
Somatic poetics
Authors: Waite Clea T.
Published: May 2022

This article considers scientific data and methods taken as a vocabulary for a visual language of poetics, shaping an artistic practice exploring the liminal poetics of space, time, science and mythology, equally considered. These artworks focus on the moving image as an immersive, architectonic construct, one that makes it possible to blur the boundary between space and time. They are cinematic environments that create a space of spatial and temporal ambiguity, open to the performative role of the viewer in composing the unfolding narrative. The artworks presented here began in the crossover between art and science, technology and anthropology, exploring topics and incorporating methods from each area. Transdisciplinary processes play a critical role in this artistic research. These works reflect cinema approached as a multimodal field of possibilities in which montage motivates movement and focus through this field, creating a participatory composition of sight, sound, movement and memory that immerses viewers by actuating somatic perception. Shape, scale, immersion, interactivity, simultaneity, embodiment, implementation and the manipulation of time create concrete metaphors that echo the multivalent content of the works: a collaboration with 300 tropical spiders to create a Kino, then letting the audience walk freely among them (or the spiders freely among the audience); an immersive environment enacting the space-time of glacial ice to experience the time of a different form of matter as somatosensory experience; a journey through the human history of the Moon, transcending time, political ideologies, realities and cultures as an encompassing field of simultaneous views and sounds; performing a 2000-year-old act of Thessalian magic on the skyline of Hong Kong. Combining the technological tools available to cinema and science, contrasting magnifications and speeds of observation reveal a material poetics beyond appearance. The artworks presented here elaborate the details of cardinal subjects, diving deep into fundamental domains to unravel the cultural implications embedded within the aesthetics of their data artefacts.
Body shopping: Challenging convention in the donation and use of bodily materials through art practice
Authors: Mackenzie Louise , Turkmendag Ilke , Burr-Raty Isabel , Hunter WhiteFeather , Jarvis Charlotte , Simun Miriam , Tapio Hege , Zaretsky Adam
Published: May 2022

The historical context of body and tissue donation is deeply problematic, with patriarchal and colonial narratives. The contemporary context of molecular and genetic biology further complicates issues of bodily donation through narratives of abstraction and extraction. As practitioners working outside the conventional boundaries of scientific study learn the tools and techniques to extract and use bodily materials, they are also learning and challenging the procedures and processes. This article approaches questions of bodily donation through the edited transcript of a conversation between artists who regularly use body fluids and cellular bodily materials in their practice, moderated by Louise Mackenzie and Ilke Turkmendag as part of the Taboo–Transgression–Transcendence in Art & Science Conference held online with the support of the University of Applied Arts, Vienna, 2020. The panel challenged the ethical and conceptual assumptions made in biotechnological research and reconsidered where the boundaries of the body lie, what ‘authority’ research carries and what choices researchers make when using the bodies of others. The transcribed conversation addresses taboos of the female body, specifically menstruation, the commodification of tissue from female human bodies, human milk politics and questions biopolitical treatment of the female body. The full, unedited panel conversation, including questions from the audience, and an accompanying video of edited interviews with panellists, is available online at https://www.loumackenzie.com/offering-the-body.
Cybernetic exchanges in online events: Seven types of conversation in the ASC2020 Global Conversation
Authors: Herr Christiane M.
Published: May 2022

As the first large online event of the American Society for Cybernetics, the ASC2020 Global Conversation offered an opportunity to develop new online types of cybernetic conversations on cybernetics, in cybernetic formats. This article discusses the design decisions that led to a particular organizational structure of the event, and observations on how the event unfolded from this organizational structure. Based on observations made throughout the event as well as its preparation stage, the article maps seven different types of conversations taking place before and during the event and discusses opportunities and constraints encountered in relation to each identified type. As online conferences have proliferated exponentially due to the impact of COVID-19, this article aims to contribute a cybernetic perspective to the broader discourse on scholarly international exchange in online media, and offers a new perspective on how such conversations might be designed in a cybernetic manner.
ecografía de tiroides realizada por profesionales no radiólogos
Authors: Alonso-Torres Ana , Monte-González Juan Carlos , Castaño-Saiz Alba María , Aragonés-García María , Familiar-Carrasco Verónica , Baudraxler Franziska
Published: May 2022

Introducción: En los últimos años ha crecido el interés de especialistas no radiólogos por la ecografía de tiroides. Desde nuestro punto de vista como especialistas en imagen, en este artículo repasaremos los puntos de partida que estos especialistas deben de tener en cuenta antes de enfrentarse a la tarea de integrar la ecografía en su práctica diaria. Material y método: Hemos realizado una búsqueda bibliográfica en la base de datos Pubmed. Nos hemos basado asimismo en documentación disponible en la Web de sociedades de imagen médica como la Sociedad Española de Ultrasonografía (SEUS) y el American College of Radiology (ACR). Discusión: Tratamos varios puntos esenciales. En primer lugar, describimos como ha de ser el proceso ecográfico en sentido amplio. Después, abordamos aspectos técnicos básicos que es imprescindible conocer. Finalmente, nos centramos en la interpretación de las imágenes, para lo cual, explicamos el estudio sistemático de la glándula y abordamos brevemente la patología tiroidea más frecuente, el nódulo tiroideo bajo la perspectiva del sistema TIRADS y la enfermedad tiroidea difusa. Conclusión: La ecografía es actualmente una técnica accesible para muchas especialidades. Entre ellos el otorrinolaringólogo puede beneficiarse en su práctica diaria. Es importante, sin embargo, contar con programas de formación y ser rigurosos al realizarla, con correcto archivo de las imágenes y realización de informes. En la valoración del nódulo tiroideo, el sistema ACR-TIRADS es útil para sistematizar su manejo. La ecografía es también útil en la detección de enfermedad tiroidea difusa.
Amelioration of aflatoxin acute hepatitis rat model by bone marrow mesenchymal stem cells and their hepatogenic differentiation
Authors: Abo-Aziza Faten A. M. , Zaki Abdel Kader A. , Adel Rana M. , Fotouh Ahmed
Published: May 2022

Background and Aim: Bone marrow-derived mesenchymal stem cells (BM-MSCs) transplantation and their hepatogenic differentiated cells (HDCs) can be applied for liver injury repair by tissue grafting. Regenerative potentiality in liver cirrhosis models was widely investigated; however, immunomodulation and anti-inflammation in acute hepatitis remain unexplored. This study aimed to explore the immunomodulatory and evaluate twice intravenous (IV) or intrahepatic (IH) administration of either BM-MSCs or middle-stage HDCs on aflatoxin (AF) acute hepatitis rat model.

Materials and Methods: BM-MSCs viability, phenotypes, and proliferation were evaluated. Hepatogenic differentiation, albumin, and a-fetoprotein gene expression were assessed. AF acute hepatitis was induced in rats using AFB1 supplementation. The transplantation of BM-MSCs or their HDCs was done either by IV or IH route. Hepatic ultrasound was performed after 3-weeks of therapy. Cytokines profile (tumor necrosis factor-α [TNF-α], interleukin [IL]-4, and IL-10) was assessed. Hepatic bio-indices, serum, and hepatic antioxidant activity were evaluated, besides examining liver histological sections.

Results: Acute AFB1 showed a significant increase in TNF-α (p<0.01), liver enzyme activities (p<0.05), as well as decrease in IL-4, IL-10, and antioxidant enzyme activities (p<0.05). Cytokines profile was ameliorated in groups treated with IV and IH BM-MCs, showed a negative correlation between IL-4 and TNF-α (p<0.05), and a positive correlation between IL-10 upregulation and TNF-α (p<0.01). In IV HDCs treated group, positive correlations between IL-4 and IL-10 downregulation and TNF-α were observed. However, in IH HDCs group, a significant positive correlation between IL-4 and IL-10 upregulation and TNF-α, were recorded (p<0.05). In addition, IV BM-MSCs and IH HDCs treatments significantly increased antioxidant enzymes activity (p<0.05). IV and IH BM-MSCs significantly ameliorated liver transaminase levels, whereas IH HDCs significantly ameliorated alanine aminotransferase activity and nitric oxide concentration (p<0.05).

Conclusion: The administration routes of BM-MSCs did not demonstrate any significant difference; however, the IH route of HDCs showed significant amelioration from the IV route. On the other hand, it showed noticeable anti-inflammatory and immunomodulatory improvements in aflatoxicosis rats. Therefore, it can be concluded that acute hepatitis can be treated by a noninvasive IV route without the expense of hepatogenic differentiation. Further research using clinical trials that address several problems regarding engraftment and potentiation are needed to determine the optimal manipulation strategy as well as to achieve better long-term effects.
Coping with oil spills: oil exposure and anxiety among residents of Gulf Coast states after the Deepwater Horizon Oil Spill
Authors: Goldman Zachary E. , Kaufman John A. , Sharpe J. Danielle , Wolkin Amy F. , Gribble Matthew O.
Published: May 2022

In April 2010, a fatal explosion on the Deepwater Horizon drilling rig in the Gulf of Mexico resulted in the largest marine oil spill in history. This research describes the association of oil exposure with anxiety after the Deepwater Horizon Oil Spill and evaluates effect modification by self-mastery, emotional support and cleanup participation. To assess the impacts of the Deepwater Horizon Oil Spill, the Centers for Disease Control and Prevention (CDC) conducted the Gulf States Population Survey (GSPS), a random-digit-dial telephone cross-sectional survey completed between December 2010 and December 2011 with 38,361 responses in four different Gulf Coast states: Louisiana, Florida, Alabama and Mississippi. Anxiety severity was measured using the Generalised Anxiety Disorder (GAD) symptom inventory. We used Tobit regression to model underlying anxiety as a function of oil exposure and hypothesised effect modifiers, adjusting for socio-demographics. Latent anxiety was higher among those with direct contact with oil than among those who did not have direct contact with oil in confounder-adjusted models [β = 2.84, 95% confidence interval (CI): 0.78, 4.91]. Among individuals with direct contact with oil, there was no significant interaction between participating in cleanup activities and emotional support for anxiety (p = 0.20). However, among those with direct contact with oil, in confounder-adjusted models, participation in oil spill cleanup activities was associated with lower latent anxiety (β = −3.55, 95% CI: −6.15, −0.95). Oil contact was associated with greater anxiety, but this association appeared to be mitigated by cleanup participation.
ANÁLISE DA ANSIEDADE DE ALUNOS, TÉCNICOS E PROFESSORES DE UM CAMPUS DE UMA UNIVERSIDADE FEDERAL DO SUL DO PAÍS
Authors: Munhoz Paula Gulart , Borges Gustavo da Rosa
Published: May 2022

A ansiedade é uma temática que vem chamando a atenção dos pesquisadores; inclusive, níveis excessivos dela podem implicar problemas pessoais e sociais, cada vez mais comuns nos dias atuais. Buscando conhecer o nível de ansiedade de alunos, técnicos e professores de uma universidade federal do sul do Brasil e relacioná-la com algumas características pessoais e profissionais, realizou-se uma survey com a participação de 365 envolvidos. Por meio de estatística descritiva, regressão, Anova e Teste-t, evidenciou-se que alunos são mais ansiosos que técnicos e professores. Além disso, constatou-se que alunos mais novos possuem mais ansiedade, sendo que alunas as possuem em maior nível. Os resultados sugerem que a ansiedade se relaciona com a empregabilidade; já que alunos mais novos geralmente não têm uma posição profissional mais desenvolvida, ademais, ela se relaciona com a característica hormonal, já que estudantes do sexo feminino a possuem com mais intensidade. Tendo em vista que a ansiedade atrapalha a vida pessoal e o rendimento acadêmico, sugere-se que universidades busquem dar mais atenção a esse tema, visto que alunos ansiosos podem corroborar com situações indesejadas.
Exportações em intensidade tecnológica e o crescimento econômico das microrregiões da região Nordeste do Brasil
Authors: De Souza Adeilson Elias , Feistel Paulo Ricardo , Da Silva Magno Vamberto Batista
Published: May 2022

O objetivo da pesquisa é avaliar a relação entre as exportações, desagregadas por nível de intensidade tecnológica, e o crescimento econômico das microrregiões nordestinas no período de 2010 a 2016. Para isso, foi estimado o modelo de crescimento econômico proposto por Cuaresma e Wörz (2005) em dados em painel. Os resultados apontaram que as exportações de baixa intensidade tecnológica contribuem para redução do crescimento econômico das microrregiões do Nordeste, ao possuírem produtividade inferior que a do setor doméstico. Nesse sentido, as microrregiões Nordestinas necessitam de investimentos nos setores de infraestrutura e P&D, para se desenvolver economicamente.
Teoria monetária moderna: descrição, evidências, limites e avanços no financiamento do desenvolvimento e na atenuação da crise da pandemia de Covid 19 no Brasil
Authors: Rocha de Lima Victor José
Published: May 2022

Este estudo realiza discussão sobre a Teoria Monetária Moderna: demonstra a origem e função da moeda ao longo da história; compara a teoria monetária clássica com a TMM; revela como opera um Estado monetariamente soberano, detalha as políticas monetárias, fiscais e cambiais, e indica os limites concretos e reais da soberania monetária; demonstra o papel da soberania monetária na busca pelo desenvolvimento e na atenuação aos efeitos danosos da pandemia da Covid-19 a partir do financiamento de políticas públicas. O trabalho conclui sobre a necessidade de se instaurar um novo regime macroeconômico no Brasil.
Impactos econômicos e distributivos de comércio do CPTPP sobre as macrorregiões brasileiras
Authors: Gelatti Elisangela , Arruda Coronel Daniel , Costa Gurgel Angelo , Thais Tolfo Gabbi Maiara
Published: May 2022

Este trabalho objetivou analisar os possíveis impactos econômicos e distributivos de comércio do CPTPP-Acordo Abrangente e Progressivo para a Parceria Transpacífico sobre os principais setores econômicos e sobre o bem-estar das famílias nas macrorregiões brasileiras, sob hipóteses alternativas quanto à possível integração do Brasil em tal acordo. Utilizando-se de um Modelo de Equilíbrio Geral Computável para a Economia Brasileira (PAEG), evidenciou-se que adesão do Brasil ao CPTPP converge para uma diminuição nas desigualdades do bem-estar das famílias das macrorregiões brasileiras, além de estimular as exportações brasileiras, em especial do agronegócio. Já a não participação tem efeitos nocivos à economia brasileira.
emergência dos coletivos de estudantes negros(as) e o combate à escassez epistemológica
Authors: Costa Lia Keller Ferreira , Reis Maria Clareth Gonçalves
Published: May 2022

O presente artigo é um recorte da pesquisa de mestrado em Políticas Sociais, realizado na Universidade Federal do Norte Fluminense Darcy Ribeiro – UENF, na qual buscou-se realizar um levantamento dos coletivos de estudantes negros(as) das universidades públicas do Estado do Rio de Janeiro. Este levantamento teve como uma de suas etapas a realização de um Estado da Arte, constituído a partir de pesquisas realizadas em repositórios digitais de teses e dissertações, o qual focalizaremos neste artigo. O Estado da Arte suscitou algumas discussões sobre o contexto de surgimento dos coletivos de estudantes negros(as) universitários(as), a participação desses coletivos nas lutas pelas políticas de cotas raciais e a importância dos mesmos nas lutas por novas epistemologias no processo de formação profissional e científica do Ensino Superior, as quais enfatizaremos.
Farmácia para comunidade
Authors: Nascimento Júnior Braz José do , Santos Manoel Augusto Freitas , Souto Lidione Brito , Alencar Angely Anny de Castro , Vieira Denes Dantas
Published: May 2022

Compartilhar informações saudáveis com a comunidade é a finalidade da educação popular em saúde. Nesse sentido, o objetivo deste trabalho foi divulgar as ações de um projeto que buscou aplicar conhecimentos científicos na promoção da saúde, tendo como público-alvo adolescentes escolares. A metodologia deste relato de experiência está baseada em dois eventos de extensão, um festival cultural e uma feira de saúde. O festival trabalhou com temas da saúde, por meio do psicodrama pedagógico, teatro, paródias e literatura de cordel. A feira buscou promover a saúde por meio da exposição de modelos didáticos, jogos educativos e mesas temáticas. O festival teve a participação de 78 alunos de escola de Ensino Médio, que serviram de plateia interativa, além de 122 alunos de graduação em Farmácia que apresentaram os temas e 5 professores avaliadores. A feira teve a participação de 13 professores avaliadores e 120 graduandos expositores. Conclui-se que o projeto foi um sucesso dentro de suas propostas metodológicas e pedagógicas, pois realizou atividades de educação em saúde com os adolescentes, contextualizando o processo de ensino-aprendizagem a partir de ferramentas lúdicas.