bluuebunny/crossref_metadata_2025 huggingface dataset:
Poly‐amido‐saccharides (PASs): Characterization of the Secondary Structure and Protein Interactions
Authors: Blessing William , Chin Stacy , Dane Eric , Grinstaff Mark
Published: June 2021

Natural polysaccharides are of significant interest in chemistry and biochemical research because of their structural diversity and essential roles in physiological processes. Many proteins are known to interact with natural carbohydrates to illicit a physiological or metabolic response. Challenges of studying these responses stem from obtaining the carbohydrate polymers, especially of high molecular weights. Currently, they must be extracted, which can introduce variation between samples and require extensive purification. We have developed a method using anionic ring‐opening polymerization to synthesize high‐yields of enantiopure carbohydrate‐based polymers: poly‐amido‐saccharides (PASs). PASs can be synthesized with consistency, defined molecular weights, low polydispersity, and high functionalization.

PASs contain the distinct chiral, cyclic main‐chain structure and pyranose backbone and are joined by an unnatural α‐(1,2)‐amide linkage, which affords PASs with unique chemical properties and structures. The helical structure of PASs elucidated through circular dichroism equips PASs with a multitude of potential functionalities including protein stabilization. This is crucial to investigate protein‐carbohydrate interactions that are necessary for protein stability. Here, we will describe how the structure of PASs contributes to its capability to stabilize proteins by comparing PASs derived from glucose and galactose based monomeric units and a mixture of both monomeric units. Furthermore, we will use PASs as a novel synthetic tool to mimic and probe carbohydrate‐protein‐mediated processes such as binding with lectin concanavalin A and galactose receptor‐mediated endocytosis.
Gene expression and coexpression alterations marking evolution of bladder cancer
Authors: Stroggilos Rafael , Frantzi Maria , Zoidakis Jerome , Mavrogeorgis Emmanouil , Mokou Marika , Roubelakis Maria G , Mischak Harald , Vlahou Antonia
Published: June 2021

Despite advancements in therapeutics, Bladder Cancer (BLCA) constitutes a major clinical burden, with locally advanced and metastatic cases facing poor survival rates. Aiming at expanding our knowledge of BLCA molecular pathophysiology, we integrated 1,508 publicly available, primary, well-characterized BLCA transcriptomes and investigated alterations in gene expression with stage (T0-Ta-T1-T2-T3-T4). We identified 157 genes and several pathways related prominently with cell cycle, showing a monotonically up- or down-regulated trend with higher disease stage. Genome wide coexpression across stages further revealed intrinsic and microenvironmental gene rewiring programs that shape BLCA evolution. Novel associations between epigenetic factors (CBX7, ZFP2) and BLCA survival were validated in external data. T0 together with advanced stages were heavily infiltrated with immune cells, but of distinct populations. We found AIF1 to be a novel driver of macrophage-based immunosuppression in T4 tumors. Our results suggest a continuum of alterations with increasing malignancy.
Tachycardia evoked from insular stroke in rats is dependent on glutamatergic neurotransmission in the dorsomedial hypothalamus
Authors: Marins Fernanda Ribeiro , Limborço‐Filho Marcelo , Iddings Jennifer A. , Xavier Carlos Henrique , Biancardi Vinicia C. , Stern Javier E. , Ramiro Diaz Juan , Oppenheimer Stephen M. , Filosa Jessica A. , Peliky Fontes Marco Antônio
Published: June 2021

Background and purpose

Damage to the insula results in cardiovascular complications. In rats, activation of N‐methyl‐d‐aspartate receptors (NMDARs) in the intermediate region of the posterior insular cortex (iIC) results in sympathoexcitation, tachycardia and arterial pressure increases. Similarly, focal experimental hemorrhage at the iIC results in a marked sympathetic‐mediated increase in baseline heart rate. The dorsomedial hypothalamic region (DMH) is critical for the integration of sympathetic‐mediated tachycardic responses. Here, whether responses evoked from the iIC are dependent on a synaptic relay in the DMH was evaluated.

Methods

Wistar rats were prepared for injections into the iIC and DMH. Anatomical (tracing combined with immunofluorescence) and functional experiments (cardiovascular and sympathetic recordings) were performed.

Results

The iIC sends dense projections to the DMH. Approximately 50% of iIC neurons projecting to the DMH express NMDARs, NR1 subunit. Blockade of glutamatergic receptors in the DMH abolishes the cardiovascular and autonomic responses evoked by the activation of NMDARs in the iIC (change in mean arterial pressure 7 ± 1 vs. 1 ± 1 mmHg after DMH blockade; change in heart rate 28 ± 3 vs. 0 ± 3 bpm after DMH blockade; change in renal sympathetic nerve activity 23% ± 1% vs. −1% ± 4% after DMH blockade). Experimental hemorrhage at the iIC resulted in a marked tachycardia (change 89 ± 14 bpm) that was attenuated by 65% ± 5% (p = 0.0009) after glutamatergic blockade at the DMH.

Conclusions

The iIC‐induced tachycardia is largely dependent upon a glutamatergic relay in the DMH. Our study reveals the presence of an excitatory glutamatergic pathway from the iIC to the DMH that may be involved in the cardiovascular alterations observed after insular stroke.
Relationship between sleep respiration, architecture and childhood enuresis: Correlates between polysomnography and questionnaire
Authors: Martenstyn Jordan A , Machaalani Rita , Caldwell Patrina , Waters Karen A
Published: June 2021

Aim

Nocturnal enuresis (NE) and sleep‐disordered breathing (SDB) are common in childhood. While the two disorders are linked, those links are still being clarified.

Methods

This study compared sleep profiles and enuresis‐related behaviours between children with NE and those without, who were referred to a tertiary sleep unit with suspected SDB, using the combination of polysomnography (PSG) and questionnaire. Continuous numerical data were analysed after adjusting for body mass index z‐score.

Results

The study included 52 Children (39 boys, 13 girls) aged 5–14 years. Twenty‐one had enuresis (10 monosymptomatic enuresis (MNE) and 11 non‐monosymptomatic enuresis (NMNE)) and 31 did not have enuresis. The majority had comorbidities. On PSG, all children with NE had moderate obstructive sleep apnoea (OSA) compared to the control group which were of mild OSA. Children with NMNE had a higher percentage time in stage‐3 non‐REM sleep when compared to the non‐enuretic and MNE groups (P < 0.05). On the questionnaire, more parents of the NE groups reported that their child was ‘difficult to wake in the morning’ (P < 0.05).

Conclusion

In this heterogeneous population referred for suspected SDB, children with NE had moderate OSA, yet those with MNE had increased arousals and more often report difficulty waking than children with suspected SDB who do not wet, while children with NMNE exhibit changes in sleep architecture suggesting deeper sleep. These differences may impact treatment choices for children with enuresis.
Real single grain grinding FEM simulation for case-hardened steel based on equivalent contact area analysis
Authors: Lerra Flavia , Liverani Erica , Landi Enrico , Fortunato Alessandro
Published: June 2021

Grinding is an indispensable phase in the gear production chain as it allows very stringent requirements characteristic of the automotive sector to be satisfied. The main goal of this finishing process is to ensure compliance with the surface integrity and dimensional tolerance specifications of the product. A single-grain grinding FEM model has been implemented to predict grinding load values based on real grain geometry using a set of Johnson & Cook coefficients able to represent the flow stress curve of a typical gear case-hardened steel 27MnCr5. Grain geometry acquired through computed tomography was imported into three-dimensional process simulation software DEFORM-3D. As the use of real grain geometry leads to time-consuming simulations, an equivalent defined geometry grain was implemented to compare cutting behavior and calculate maximum force values through real contact area analysis under the same process parameters. Calculated loads were subsequently compared with experimental results, showing good agreement with a maximum percentage difference less than 13% for two different grain geometries. Grinding force measurements were performed in a single-grain configuration on a CNC surface grinding machine adopting a wheel speed of 384 rad/s, feed rate of 8.6 mm/s and a depth of cut of 0.1 mm.
Motor Learning: Reflections on the Past 40 Years of Research
Authors: Lee Timothy D. , Carnahan Heather
Published: June 2021

The authors reflect on the dire state of motor learning at the time of Brooks’s book and consider reasons why research was resurrected in the 1980s and flourished in the ensuing years. In so doing, they provide an overview of the various research topics that have been studied, discuss the influence of motor learning on other fields of study, and consider the future of motor learning research both within and outside the academic study of kinesiology.
Rhodobacter sphaeroides CarD Negatively Regulates Its Own Promoter
Authors: Henry Kemardo K. , Ross Wilma , Gourse Richard L.
Published: June 2021

R. sphaeroides
CarD activates many promoters by binding directly to RNAP and DNA just upstream of the −10 element. In contrast, we show here that CarD inhibits its own promoter using the same interactions with RNAP and DNA used for activation.
Slow pyrolysis pine wood-derived biochar reduces nitrous oxide production from surface but not subsurface soil
Authors: Deng Hongyuan , Ejack Leanne , Gul Shamim , Prasher Shiv O. , Whalen Joann K.
Published: June 2021

Soil amended with biochar is expected to produce less nitrous oxide (N2O), although this may depend on nitrate (NO3-N) availability. Our objective was to determine how pine wood biochar, slow pyrolyzed at 500 °C, affects N2O production in soil having different denitrification potentials with variable NO3-N concentrations under controlled laboratory conditions. Sandy loam surface soils (0–30 cm, pH 5.7) and sandy clay loam subsurface soils (40–60 cm, pH 5.6) were amended with four biochar rates (0, 10, 20, and 30 g·kg−1), two nitrogen fertilizer rates (0 and 100 mg·kg−1 NO3-N) and two acetylene levels (0% and 10% headspace), arranged as a full factorial. Soil moisture content was adjusted to 80% water-filled pore space, and flasks were incubated at 20 °C for 30 h. Headspace gas was collected from each flask at 25, 26, 28, and 30 h. There was a significant reduction in N2O production with an increasing rate of biochar in the surface soil but not in the subsurface soil. On average, less N2O was produced in the subsurface soil than in the surface soil. As the NO3-N concentration was not a limiting factor for denitrification, the most likely explanation was that denitrifier activity was influenced by the availability of soluble organic carbon in the soil–biochar mixtures. We recommend further study of the coupled carbon–nitrogen transformations during denitrification to understand how biochar influences soil N2O production in sandy loam soils.
The Classification System of Literary Works Based on K-Means Clustering
Authors: Wei Sanqiang , Hou Hongxia , Sun Hua , Li Wei , Song Wenxia
Published: June 2021

The plots in certain literary works are very complicated and hinder readers from understanding them. Therefore tools should be proposed to support readers; comprehension of complex literary works supports their understanding by providing the most important information to readers. A human reader must capture multiple levels of abstraction and meaning to formulate an understanding of a document. Hence, in this paper, an Improved K-means clustering algorithm (IKCA) has been proposed for literary word classification. For text data, the words that can express exact semantic in a class are generally better features. This paper uses the proposed technique to capture numerous cluster centroids for every class and then select the high-frequency words in centroids the text features for classification. Furthermore, neural networks have been used to classify text documents and k-mean to cluster text documents. To develop the model based on unsupervised and supervised techniques to meet and identify the similarity between documents. The numerical results show that the suggested model will enhance to increases quality comparison of the existing Algorithm and K-means algorithm, accuracy comparison of ALA and IKCA (95.2%), time is taken for clustering is less than 2 hours, success rate (97.4%) and performance ratio (98.1%).
The Effect of Creep Rate on Polymeric Composites Reinforced by Nanoclays and their Comparison
Authors: Khalifah Khalid Mohammed
Published: June 2021

The aim of this study is to prepare composite nanomaterials and to improve some of their mechanical properties as a creep rate using nanoparticles that are prepared in the laboratory by ultrasound available using Impact Polystyrene (HIPS) and Polyethylene (HDPE) as matrix materials. Nanoclays are made of Bentonite-reinforced materials. This research studies the addition of nanoclays with thermos plastic polymers in weight fraction percentage (1%, 2%, 3% and 4%) and makes a comparison among them.
INFLUENCE OF THE PROFESSIONAL ENGLISH LANGUAGE TEACHING QUALITY ON THE ACHIEVEMENTS OF A SUBJECT STUDY BY MEDICAL STUDENTS
Authors: Yelahina N. I. , Fedchyshyn N. O.
Published: June 2021

The article analyzes some aspects of the influence of a teacher’s personality on the formation and development of students’ academic performance. The relevance of the study of personal qualities of a teacher as a guarantee of high-quality mastering of Professional English by medical students is justified in the article. On the background of this thematic area of theoretical and scientific concerns, our study tackles and develops specific aspects of the influence of the teaching skills on the quality of the content and objectives of Professional English language teaching in a medical institution of higher education. The article deals with the approaches of modern researchers to the professional activity of a teacher in a higher educational institution and presents a psychological perspective of the problem, taking into account the components of high-quality education. The involvement of the academics in the complex activities specific to higher medical educational process places the act of teaching Professional English among the defining priorities of meeting quality, national and international standards of academic medical education. As a defining activity aimed at the enhancement of the teachers’ competencies, teaching Professional English is a priority and decisive value across all the other disciplines which contribute to achieving the quality of higher medical education, being, in fact, the central intercultural core that provides substance, consistency and strength to the intercultural dimension of the academic medical education.
A Poesia Aberta do Israelense Amir Or
Authors: Amâncio Moacir
Published: June 2021

O poeta isralense Amir Or, nascido, 1956, Tel Aviv, escreve uma poesia marcada pela riqueza de modelos e temas, nos quais quais estão presentes tanto questões políticas, históricas e literárias do seu país, quanto assuntos e gêneros literários de outras culturas, inclusive do Extremo Oriente. Ele usa a poesia como um exercício multicultural escrito em hebraico. Com isso, participa de uma jornada inovadora, ao mesmo tempo em que reafirma o trabalho iniciado pelos poetas pioneiros de Israel, empenhados em colocar a língua dos profetas ao lado dos demais idiomas contemporâneos.
Tradução e o contexto cultural: será que o dicionário basta?
Authors: Rozenchan Nancy
Published: June 2021

A quantidade de fatores que interfere na tradução a partir do hebraico é mais ampla do que a da maior parte das línguas contemporâneas. Além das várias camadas históricas que compõem a língua, a fartura e a diversidade de elementos culturais imbricados atualmente na linguagem coloquial apon- tam para a dificuldade do tradutor cumprir os seus propósitos baseando-se somente em dicionários. Através de exemplos, são indicados alguns destes elementos culturais.
Rasgar el presente: memoria y fabulación en relato de um certo oriente
Authors: Kanzepolsky Adriana
Published: June 2021

nulo
Middle Chinese labial softening
Authors: Gao Yipeng
Published: June 2021

Labiodentalization was an important phonetic change in Middle Chinese sounds. This essay introduces and analyzes Chinese scholars’ views and arguments on some problems on labiodentalization. These problems contain the exact time when the labiodentals developed from the bilabials in phonetic value, the condition of development and a special phenomenon of the onset spellers in the Division-III rhymes.
Mechanism of Aquaporin-4 Up-Regulation After Traumatic Brain Injury and Preventative Action of Astragalus Polysaccharides in Mice
Authors: Li Bin , Yuan Honggang , Li Huibing , Luo Baochang , Yu Xiaoping , Wang Yanhua , Liu Wen
Published: June 2021

Here, we aimed to clarify the anti-inflammatory function of Astragalus Polysaccharides (APS), a chemical compound derived from Astragalus membranaceus, and the action of AQP4 on brain injury. We hypothesized that APS could improve the traumatic brain injury (TBI) outcome via
inhibiting expression of AQP4 in astrocytes. The present study elucidated that AQP4 was up-regulated and was effectively blocked by APS in mice with severe controlled cortical impact (CCI). Pre-treatment with APS effectively inhibited the up-regulation of AQP4 and diminished the neurological
deficits in mice. Additionally, primary astrocytes treated with mechanically-injured astrocyte supernatant, to mimic TBI in vitro, showed a significant up-regulation in swelling. We confirmed various signal molecules (NF-ĸB, MAPKs, and ERK) to have a role in astrocyte
swelling, after activation in trauma, and to be involved in the up-regulation of AQP4. These signal molecules also significantly decreased with APS treatment. In conclusion, our study suggests that APS attenuated neurological deficits and brain edema by decreasing AQP4 up-regulation in astrocytes
following TBI in mice, via reducing NF-ĸB, MAPKs, and the ERK signal molecules.
Long Non-Coding RNA Small Nucleolar RNA Host Gene 1 and MicroRNA-100-3p Expression in Endometrial Carcinoma and Its Effect on the Proliferation and Apoptosis of Ishikawa Cells
Authors: Mao Jiana , Liu Yulan , Shen Cainuo , Duan Xiaoxia , Chen Yier
Published: June 2021

The aim of this study was to explore LncRNA SNHG1 and miRNA-100-3p expression in endometrial carcinoma and its effect on the proliferation and apoptosis of Ishikawa cells. A qRT-PCR assay was conducted to determine SNHG1 and miRNA-100-3p expression in endometrial cancer tissues and
paracancerous tissues. Human endometrial cancer Ishikawa cells were cultured in vitro. Si-NC, si-SNHG1, si-SNHG1, anti-miRNA-NC, and si-SNHG1 were transfected into Ishikawa cells with anti-miRNA-519b-3p. A qRT-PCR assay was performed to determine SNHG1 and miRNA-100-3p expression, and
the CCK-8 method was used to determine cell proliferation. Flow cytometry was conducted to determine cell cycle and apoptosis rate and a dualluciferase reporter experiment was carried out to test the targeting association between SNHG1 and miRNA-100-3p. Cleave Caspase-3, CHOP, and ATF4 expression
were determined with the Western Blot method. SNHG1 expression level and miRNA-519b-3p expression level were much higher and much lower, respectively, in endometrial cancer tissues than in paracancerous tissues (P < 0.05). Transfection of si-SNHG1 can greatly attenuate cell viability
and S cell ratio (P < 0.05), and increase G0/G1 cell ratio, apoptosis rate, Cleaved Caspase-3, CHOP, and ATF4 protein level (P < 0.05) compared to the si-NC group. Furthermore, the double luciferase reporter experiment confirmed that SNHG1 can competitively combine withmiRNA-100-3p.
Also, co-transfection of si-SNHG1 and anti-miRNA-100-3p could significantly increase cell viability and S cell ratio (P < 0.05), and decrease G0/G1 cell ratio and apoptosis rate, and Cleaved Caspase-3, CHOP, and ATF4 protein levels compared to si-SNHG1+anti-miRNA-NC (P <
0.05). Interfering with SNHG1 could inhibit the proliferation of Ishikawa cells and promote apoptosis by upregulating miRNA-100-3p expression.
Design of New Chlorochalcone Derivatives as Potential Breast Anticancer Compound Based on QSAR Analysis and Molecular Docking Study
Authors: Puspitasari Anita Dwi , Pranowo Harno Dwi , Astuti Endang , Wahyuningsih Tutik Dwi
Published: June 2021

Quantitative structure-activity relationships (QSAR) proposes a model that relates the biological activities of drugs to their chemical structures, and the interaction between the drug and its target enzyme is revealed by molecular docking research. These studies were conducted on chalcone to produce a model that could design highly potent breast anticancer MCF7 cells. The compounds were optimized using ab initio using a basis set 6-31G, then their descriptors calculated using this method. Genetic Function Algorithm (GFA) was used to select descriptors and build the model. One of the six models generated was found to be the best with internal and external squared correlation coefficient (R2) of 0.743 and 0.744, respectively, adjusted squared correlation coefficient (adjusted R2) of 0.700, Standard estimate of error (SEE) of 0.198, Fcalc/Ftable of 6.423, and Predicted residual sum of squares (PRESS) of 1.177. The QSAR equation is pIC50 = 3.869 + (1.427 x qC1) + (4. 027 x qC10) + (0.856 x qC15) - (35.900 x ELUMO) + (0.208 x Log P). Hence, it can predict the breast anticancer activities of new chlorochalcones A-F. The compound with the best prediction was chlorochalcone A with pIC50 2.65 and IC50 value of 2.26 μM. The chlorochalcones A-F were able to bind to the main amino acid residues, namely Arg120 and Tyr355, on the active site of the COX-2 enzyme. These results could serve as a model for designing novel chlorochalcone as inhibitors of COX-2 with higher breast anticancer activities.

Keywords: Chlorochalcone, COX-2, QSAR, MCF-7, Molecular docking
Is There Evidence to Support a Relationship between Temporomandibular Disorders (TMD) and Headache? – A Systematic Review
Authors: Lemejda Justyna Agnieszka , Loster Jolanta E.
Published: June 2021

BACKGROUND Headache and migraine can lead to depression by worsening the mood and producing an unpredictable disorganisation of life. Temporomandibular disorders (TMD) are associated with headache. Tenderness of the masticatory muscles, especially in young patients, and pain in the temporomandibular joint area are also associated with migraine, which can cause headaches of varying degrees of intensity. This article presents a literature review on the relationship between the occurrence of headache and the symptoms of TMD. METHODS The inclusion criteria were English-language articles published since 2007 that classify TMD using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC / TMD) questionnaire, and which described headache using the International Classification for Headache Disorders (second and third editions) or the headache screening questionnaire (HSQ). RESULTS Fifteen qualifying articles were found. Ten of these were included in the analysis. The authors noticed that the diagnoses were unclear, though it seems that these disorders have a similar background. CONCLUSION The current literature review confirms the relationship between TMD and headache. The authors of the articles generally agree that problems are more common in women, and that further research should be conducted on the correlation between these disorders. It is necessary to conduct further research using standardised assessment scales of both TMD and headache to compare the results. Such studies will allow a meta-analysis of the data, which will help to broaden our understanding of these problems and find conducive factors. KEY WORDS Temporomandibular Disorders, Headache, Tension-Type Headache, Headache Disorders, Headache Classification
A változásmenedzsment kritikus pontjai
Authors: Farkas Ferenc
Published: June 2021

Ez az írás a közelmúlt publikációinak kritikai elemzésével azokra a kritikusnak nevezhető pontokra irányítja a figyelmet, amelyek a szerző szerint, a hazai elméleti és gyakorlati szakemberek tudásbázisának növelése szempontjából is, fokozott érdeklődésre tarthatnak számot. Ezek a kritikus pontok sokfélék lehetnek. Előtérbe helyezésük és csoportosításuk minden esetben tartalmazza a szerzők szubjektivitását és prioritásait, különös tekintettel arra a tényre, hogy a változásmenedzsment komplex, sokszor zavaros (messy) problémák kezelésére irányul, amelyekben az ok-okozati viszonyok korántsem egyértelműek. Így a vizsgálandó tényezők sorrendje is akár felcserélhető lehet - függően a kutatási és gyakorlati céloktól vagy súlypontoktól.
The Hart-Fuller Debate on Law and Morality Within the Prism of the Legal Foundation of the Right to Privacy in its Earlier Jurisprudential Interpretations in German Case-Law
Authors: Lytvynenko Anatoliy A.
Published: June 2021

The 1950s debate between the British and American legal philosophers, Lon Fuller and Herbert Hart, has been a clash between the positivist and natural theories of origination of law and jurisprudence, with the former method primarily suggesting that law and morality are not necessarily interconnected, though may coincide in some occurrences, while the latter sticks to development of law that is based upon the mores and values related to human nature, which creates the standards that society should follow in order to function properly. The former approach, as it is argued, is not actually deprived of moral factors. To examine how these debates could work on practice, I decided to choose the early developments of the general right to privacy as an example of “penumbral” rights and to review the positions of various courts within adjudicating cases in respect with the general right to privacy.
Economic Effects of Public Investment Activity in Rural Municipalities of Eastern Poland
Authors: Czudec Adam , Zając Dariusz
Published: June 2021

For several years, the development of regions of Eastern Poland has been supported with funds from the European Union (EU) special programme entitled «Eastern Poland». Its goal is to stimulate the economic and social development of this part of Poland, which is one of the least developed regions in the EU. These funds are aimed at reducing development disproportions between Eastern Poland and other regions. Therefore, the question about the effects of applying financial support from public funds of these regions is justified. Our research attempts not only to find an answer to this question, but also to fill the research gap explaining the role of some factors in the reduction of regional disparities in rural areas. The paper aims to identify the factors and effects of public investment activity in rural municipalities in Eastern Poland against all rural municipalities in the country. The research hypothesis assumes that there is a positive relation between the level of municipal investment activity and the share of the municipalities’ tax revenue in the overall budget revenue, and that the level of municipal investment activity depends on geographical location of rural areas. The research covered all rural municipalities in five regions of Eastern Poland, while data have been obtained from Central Statistical Office in Poland for the period 2004–2017. A percentage share of investment spending of rural municipalities in the overall budget expenditure was used as a measure of investment activity. The study used a comparative analysis method, descriptive statistics (mean, coefficient of variation), as well as one-factor analysis of variance and linear correlation. The research has shown that investment activity in rural municipalities in Eastern Poland during the analysed period was slightly lower than in the country as a whole, with remarkable differentiation among particular municipalities. There is no single factor defining the investment capacities of local authorities, however, relatively big differences in the receipt of EU funds by rural municipalities in Eastern Poland. The findings show that the proximity to highly developed regions did not energise the economic growth of rural municipalities in Eastern Poland to the same extent as the proximity to larger cities. The research results can be used by public sector institutions in rural development programmes, including measures to improve the effectiveness of the financial investments from public funds to increase the quality of life of rural inhabitants.
Potensi dan Peluang Pengembangan Usaha Produk Kreatif Kulit Ikan Pari Komersial Skala Mikro-Kecil
Authors: Sahubawa Latif , Sasongko Heru , Permadi Ilham , Lutfia Shila
Published: June 2021

Kulit ikan pari dapat diolah menjadi produk komersial bernilai tinggi karena memiliki mutiara yang indah di permukaan. Tujuan penelitian adalah mengkaji nilai tambah, preferensi konsumen dan kelayakan finansial usaha produk kulit pari komersial. Data penelitian dianalisis dengan metode kuantitatif dan deskriptif. Analisis nilai tambah menggunakan konsep harga bahan baku dan produk akhir; analisis preferensi konsumen menggunakan pendekatan kesukaan dengan atribut model, harga dan warna produk; analisis kelayakan menggunakan indikator pendapatan, R/C ratio, PBP dan BEP pada usaha mikro-kecil Fanri Collection Yogyakarta . Produk kulit ikan pari mondol dan pari duri diolah menjadi produk utama (dompet W/P tipe 3-in-1 dan tipe 2-in-1) serta produk turunan (gantungan kunci dan gelang mutiara/manik-manik) yang digunakan untuk analisis nilai tambah. Nilai tambah dari kulit ikan pari mondol yaitu sebesar Rp920.000 (1.249,9%) serta kulit ikan pari duri sebesar Rp955.000 (816,7%). Konsumen paling menyukai produk kulit yang berwarna merah marun dibandingkan merah cerah, cokelat dan hijau lumut serta tertarik untuk membeli produk berdasarkan model dan harga. Pendapatan Fanri Collection sebesar Rp134.113.500 per tahun; nilai R/C ratio>1,0 (layak); nilai PBP pada kurun waktu 1 tahun, 7 bulan dan 7 hari; nilai BEP sebesar Rp309.775.383 atau penjualan produk sebanyak 1.936 barang per tahun. Produk yang diminati konsumen adalah gantungan kunci dan dompet W/P (wanita dan pria) tipe 3-in-1.
Identifikasi faktor penyebab dan upaya guru Geografi mengatasi rendahnya minat siswa pada kelas lintas minat Geografi SMA negeri di Kota Malang
Authors: Butarbutar Reinaldi Hasiholan , Soekamto Hadi , Kistiyanto Marhadi Slamet
Published: June 2021

Penelitian ini bertujuan untuk mengetahui faktor penyebab dan upaya guru geografi mengatasi rendahnya minat siswa pada kelas lintas minat geografi SMA Negeri di Kota Malang. Penelitian ini merupakan penelitian deskriptif kuantitatif. Penelitian ini menggunakan angket dan pedoman wawancara sebagai instrumen penelitian. Populasi dalam penelitian ini berjumlah 3437 siswa dan 18 guru geografi. Penentuan jumlah sampel untuk angket menggunakan teknik Slovin. Hasil pengumpulan pertama berupa angket yang menunjukkan bahwa (1) Faktor rasa senang (63,7 persen) (2) Faktor bakat (64,3) (3) Faktor mata pelajaran (83 persen). Hasil pengumpulan kedua berupa pedoman wawancara yang menunjukan bahwa terdapat empat upaya guru geografi mengatasi rendahnya minat siswa pada kelas lintas minat geografi. Keempat upaya tersebut yaitu: 1) Memiliki kedekatan dengan seluruh siswa (16,6) 2) Mengadakan fieldtrip (11,1) 3) Pembelajaran di Luar Ruangan (11,1) 4) Penerapan Sistem Paket Lintas Minat (11,1).
THE ROLE OF PARLIAMENT IN CURBING CORRUPTION: AN ILLUSTRATIVE APPROACH REGARDING PESHAWAR, PAKISTAN
Authors: Muhammad Bashir , Shah Mussawar , Asadullah  , Khan Naushad
Published: June 2021

Purpose of the study: This study aimed to explore the association between the role of parliament and perception of the National Accountability Bureau (NAB) paradigm for curbing corruption in Peshawar.

Methodology: A stratified random sampling technique was used to gather information from 320 sample respondents through an interview schedule. The gamma and chi-square test was applied to determine the association between dependent and independent variables.

Main Findings: Parliament’s role was termed as of paramount importance in curbing corruption. There was a significant association between the vital function of parliament in curbing corruption (P=0.000), introduce new anti-corruption laws (P=0.016), parliament assure the accountability of executives (P=0.003), parliament should work with other institution (P=0.034), Public Account Committee’s role is admirable in parliament (P=0.815), non-accountability of powerful (P=0.022), parliament should introduce a strict law (P=0.017) and perception of the NAB paradigm for reducing corruption.

Applications of this study: The results of this research work can be applied to all watchdogs’ institutions for its policymaking.

The originality of this study: The study is unique because the information was aggregated directly from the people in the research area.
PESAN NASIONALISME DALAM FILM SANG KIAI
Authors: Rijal Muhammad Fahrisur
Published: June 2021

ABSTRACT Nowadays there are lots of educational cinema films that can be used as alternatives as learning media. This is in line with the development of the film industry in Indonesia which is developing rapidly through the film with the theme of the heroism of the kiai. He appreciates that the struggle for Indonesian independence, but here is also present from the ulama 'groups which are focused through diplomacy channels spearheaded by NU scholars and students led by KH Hasyim Asy'ari. This research was conducted to analyze how the Nationalism messages of students and scholars presented in the film by using the semiotic theory of Roland Barthes and qualitative descriptive methods. The researcher can conclude that the message of nationalism in the film of the kiai always gives the messages of nationalism in various ways in every film scene that is served. In this film through the character KH. Hasyim Asy'ari emphasized the audience to always uphold the aqeedah, fight for nationalism, dare to take risks, contribute to the nation and the state as well as inspire others with the deeds done.

ABSTRAK Saat ini banyak tanyangan film-film bioskop edukatif yang dapat digunakan sebagai alternatif sebagai media pembelajaran. Hal ini sejalan dengan perkembangan dunia perfilman di Indonesia yang berkembang pesat melalui Film yang bertemakan kepahlawanan Sang Kiai ini mengapresiasikan bahwa perjungan kemerdekaan Indonesia, tetapi disini juga hadir dari kalangan ulama’ yang difokuskan melalui jalur diplomasi yang dipelopori oleh para ulama NU dan santri-santri yang di pimpin oleh KH Hasyim Asy’ari. Penelitian ini dilakukan untuk menganalisa bagaimana pesan Nasionalisme dari santri dan kiai yang tersaji dalam film dengan menggunakan teori semiotik Roland Barthes dan metode deskriptif kualitatif. Peneliti dapat menyimpulkan bahwa pesan nasionalisme dalam film sang kiai selalu memberikan pesan-pesan nasionalisme dengan bermacam cara dalam setiap adegan film yang di suguhkan. Dalam film ini melalui karakter KH. Hasyim Asy’ari menekankan kepada penonton untuk selalu memegang teguh aqidah, memperjuangkan nasionalisme, berani mengambil resiko, berkontribusi untuk bangsa dan negara juga menginspirasi orang lain dengan perbuatan yang dilakukan.
PENINGKATAN KETERAMPILAN MENULIS TEKS BERITA MENGGUNAKAN METODE MIND MAPPING DAN MEDIA VIDEO
Authors: Suwarti Indri , Pujihastuti Etin , Nugroho Bivit Anggoro Prasetyo
Published: June 2021

Penelitian ini didasarkan pada masalah rendahnya keterampilan menulis teks berita siswa kelas VIII B SMP Negeri 1 Karanglewas. Rendahnya keterampilan menulis teks berita dikarenakan siswa tidak tertarik untuk mengikuti pembelajaran bahasa Indonesia. Ketidaktertarikan siswa terhadap pembelajaran disebabkan oleh komponen pendukung dalam proses pembelajaran yang kurang maksimal yaitu guru kurang memanfaatkan metode dan media pembelajaran. Berawal dari masalah tersebut, maka peneliti menawarkan suatu alternatif metode pembelajaran yang dapat digunakan dalam pembelajaran menulis teks berita, yaitu metode mind mapping. Desain penelitian yang digunakan dalam penelitian ini adalah desain penelitian tindakan kelas (PTK) dengan menerapkan tiga siklus. Teknik pengumpulan data yang digunakan adalah teknik tes dan nontes. Teknik analisis data dalam penelitian ini menggunakan teknik kuantitatif dan kualitatif. Teknik kuantitatif digunakan untuk mengetahui hasil tes menulis teks berita siswa, sedangkan teknik kualitatif digunakan untuk mengetahui hasil nontes berupa perubahan perilaku belajar siswa. Berdasarkan hasil tes, keterampilan menulis teks berita siswa mengalami peningkatan yang dapat dilihat dari nilai rata-rata yang diperoleh pada setiap siklusnya. Pada prasiklus, nilai rata-rata yang diperoleh sebesar 61, siklus I nilai rata-rata diperoleh sebesar 71,34, dan siklus II nilai rata-rata yang diperoleh mencapai 82,94. Selain itu, berdasarkan hasil nontes juga menunjukkan adanya perubahan perilaku belajar siswa ke arah yang lebih baik.
UPAYA PENINGKATAN HASIL BELAJAR GERAK DASAR LARI DAN LOMPAT MELALUI PERMAINAN TRADISIONAL
Authors: Malik Abdul
Published: June 2021

The purpose of this study is to improve the learning results of basic motion run and jump through the traditional game in learning pemas on third grade students MIN SROYO Jaten Karanganyar teaching 2016/2017.

This research is a Classroom Action Research (CAR). This study was conducted in two cycles, consisting of four stages in each cycle consisting of planning, action implementation, observation and reflection. Subjects in Action Research This class is the third grade students MIN SROYO Jaten Karanganyar, amounting to 31 students consisting of 16 students and 15 female students. Sources of data in this study come from students, researchers and teachers who act as collaborators. Techniques of collecting data using tests and observations. Data validity using data triangulation technique. Data analysis using qualitative descriptive technique based on qualitative analysis percentage.

Result of research on prasiklus only 11 complete student (35.49%) and 20 students unfinished (64,51%). In the first cycle obtained the results of student learning that has been completed as many as 18 students (58.07%) and 13 students are not complete (41.93%). With the acquisition of affective averages (77.42%), psychomotor (35.49%) and cognitive (83.87%). In the second cycle obtained the results of student learning that has been completed as many as 26 students (83.87%) and 5 students is not complete (16.13%). With the acquisition of affective averages (96.77%), psychomotor (74.19%) and cognitive (83.87%) Based on the analysis results from cycle I and cycle II showed a significant increase and target achievement.

Based on the results of the research obtained the conclusion that: The use of simple aids in learning can improve the learning results of basic motion run and jump on the students of class III MIN SROYO Jaten Karanganyar academic year 2016/2017.
MENINGKATKAN HASIL BELAJAR MERODA SENAM LANTAI MELALUI PENGGUNAAN ALAT BANTU PEMBELAJARAN
Authors: Susanto Achwan , Syaifullah Rony
Published: June 2021

The purpose of this research is to improve learning outcomes of basic locomotor movements of walking and running through the medium of learning in class V SDLB Erha Pabelan Semarang 2017/2018.

This research is a classroom action research. This study was conducted in two cycles, each cycle consisting of two meetings. Subjects in this Class Action Research is a fifth grade students SDLB Erha Pabelan Semarang totaling 7 students consisted of five boys and two student daughters. Sources of data in this study come from students, researchers and teachers who act as collaborators.
Data collection technique used tests and observation. The validity of the data using the technique of triangulation data. Analysis of data using qualitative descriptive technique that is based on a qualitative analysis of the percentage.  Results of research on pre-cycle only two students who completed (28.57%) and 5 students are not completed (71.42%). In the first cycle of learning basic movements locomotor result students who have completed as many as four students (56.67%) and 3 students are not completed (42.85%). With the acquisition of affective (57.14%), psychomotor (57.14%) and cognitive (71.42%). In the second cycle was obtained in student learning outcomes that have been completed by 6 students (85.71%) and 1 student is not completed (14.28%). With the acquisition of affective (85.71%), psychomotor (80%) and cognitive (76.67%) Based on the analysis of the first cycle and the second cycle showed an increase in the targeted achievement.  Based on the results obtained the conclusion that: The use of the application of instructional media can improve learning outcomes basic motion forehand push in table tennis in Class V SDLB Erha Pabelan Semarang academic year 2017/2018. 
Survey of adaptive physical education learning implementation in the SLB A in Surakarta in the academic year of 2019/2020
Authors: Sandhy Afinda Devibrillianita , Nugroho Djoko , Rahayu Tri Winarti
Published: June 2021

The learning and teaching process of adaptive physical education subject in SLB A or special school A in Surakarta (SLB Negeri Surakarta and SLB A YKAB Surakarta) have faced several obstacles such as the education background of the physical education teachers which are special education background not the physical education background, teachers are still unable to pay attention to the students entirely and to the aspects included in learning implementation, the lack of learning facilities and infrastructure, adaptive physical education learning that generalizes various types of disabilities, and the inactivity of students in participating in the learning process. Therefore, this study aims to discover the implementation of adaptive physical education learning process in SLB A in Surakarta. This study used quantitative method. The approach used in this study was descriptive approach and the research method used was survey method with data collecting technique of observation, questionnaire, and document study. The collecting technique used by the author was by including all of the study’s subjects as the respondents. The collected data was analyzed and tested its validity using triangulation data and triangulation method. The result of this study shows that the Implementation of Adaptive Physical Education Learning in SLB A in Surakarta in the Academic Year of 2019/2020 is lacking based on its influenced factors. Therefore, it is necessary to review and improve the policies in the adaptive physical education learning for visual impaired students.
A Case Study of Vacuum Tube-Well Dewatering Technology for Improving Deep Soft Soil in Yangtze River Floodplain
Authors: Zeng Biao , Zhen Yu , Zhang Dingwen , Meng Tao , Gong Zejia , Liu Songyu
Published: June 2021

Deep soft soil of the Yangtze River floodplain in Nanjing has a special interlayer structure, which provides favorable conditions for the application of vacuum tube-well dewatering technology. This paper focuses on the design, construction and treatment effect of vacuum tube-well dewatering technology. The hydrological parameters and the hydraulic connections between the various layers of the site have been ascertained through two simple single-well multi-holes pumping tests. Moreover, the layout of vacuum tube-wells and depressurization wells in a test site with 84m length and 84m width was designed based on the above parameters. Field tests of vacuum tube-well dewatering technology were conducted on the test site. And the changes of groundwater level, ground settlement and pore water pressure during the test was monitored. The CPTU test technology was used to quickly evaluate the engineering properties of the site before and after treatment. Finally, combined with the settlement monitoring data, the hyperbolic method was used to predict the final settlement. The results indicated that consolidation efficiency of vacuum tube-well dewatering technology has obvious advantages. Implications of this study can provide a reference for the construction design of the site's ground improvement consolidation and other similar projects.
Diabetes mellitus indicate poor prognosis in uterine serous cancer patients
Authors: Liu Yunyun , Li Jing , Cheng Zhibo , Xu Guocai , Peng Yongpai , Huaiwu Lu
Published: June 2021

Purpose. We aimed to find prognostic factors for uterine serous cancer(USC) patients in a retrospective study.Methods. 51 USC patients between 2010-2020 were enrolled. All pathological specimens were reviewd. The research protocol was approved by Institutional Review Board and all patients were informed consent before the study began. Statistics were done using SPSS 25.0, T test and chi-square analyses were used to compare differences, the overall survival(OS) was estimated with Kaplan-Meier(KM) analysis, univariate and multivariate Cox regression analyses were utilized to find prognostic factors.Results. The median overall survival(OS) and progressive free survival(PFS) were 75.94 and 63.49 months, respectively. Diagnosed with diabetes mellitus(P=0.006, HR=6.792, 95%CI=1.726-26.722) and CA125＞28U/ml(P=0.006, HR=7.136, 95%CI=1.780-28.607) before surgery were independent risk factors for OS, advanced FIGO stage(P=0.001, HR=10.628, 95%CI=2.894-39.026) and DM(P=0.003, HR=6.327, 95%CI=1.875-21.354) were independent factors for PFS. Age≤52, , tumor size≥2.5cm and cervical mucosal infiltration may indicate poor prognosis but were not independent risk factors. Hypertension patients with routine medical treatment tend to survive longer, but there was no statistical differences in OS and PFS compared to patients with normal blood pressure.Conclusion. In addition to surgical and adjuvant treatments, gynecologists should focus more on the comorbid conditions of USC patiens, especially for DM.
Family-Based Analysis of -675 4G/5G Polymorphism in the PAI-1 Gene in Chinese Polycystic Ovary Syndrome
Authors: Ge Li , Song Cui Xiao , Wang Sha Dong , Li Li , Ma Mei Dong , Song Cui Xiao
Published: June 2021

Background: Insulin resistance (IR) is one of the main pathophysiology of PCOS. Previous studies have shown that 4G/5G polymorphism in promoter region of plasminogen activator inhibitor-1 gene(PAI-1) can affect insulin sensitivity by elevating the level and activity of plasma PAI-1, involved in the formation of IR. In order to elucidate the relationship between 4G/5G polymorphism of PAI-1 gene and PCOS, we used transmission disequilibrium test (TDT) to study the nuclear family of PCOS. Purpose: This study used family-based analysis of TDT to determine whether an association exists between 4G/5G polymorphism of PAI-1 gene and PCOS and in Han Chinese in order to identify PAI-1 gene as a genetic susceptibility factor for PCOS. Methods: Eight hundred and fifty-five participants consisting of 285 trios (mother, father and offspring with PCOS) were recruited from the Center for Reproductive Medicine, Shandong University, from July 2007 to August 2014. 4G/5G polymorphism of PAI-1 gene was genotyped using direct sequencing protocol and TDT was used to analyze the association between PAI-1 gene and PCOS. Results: Though the 5G allele in PAI-1 gene was overtransmitted in families, no statistical significance existed and there was no association between PAI-1 gene and PCOS. The levels of FINS, HOMA-IR and TG were significantly different between obese and lean PCOS and the parents.Conclusion: No significant evidence of association or linkage was found between 4G/5G polymorphism of PAI-1 gene and PCOS, indicating that PAI-1 gene was unlikely to play a major role in the etiology of PCOS in our sample.