bluuebunny/crossref_metadata_2025 huggingface dataset:
Locally-Delivered 1% Metformin Gel as an Adjunct to Scaling and Root Planning in the Treatment of Severe Chronic Periodontitis: A Randomized, Controlled Clinical Trial
Authors: Arbabi Kalati Parvin , Foroutani Mohammad Hossein , Karami Elaheh
Published: September 2024

Background: Periodontitis is a chronic inflammatory disease that affects the teeth’s supporting structures, leading to clinical attachment loss, pocket formation, and tooth loss if left untreated. Scaling and root planning (SRP) is the gold standard for removing bacterial biofilm and calculus from tooth surfaces. However, in most situations, including tooth fractures, there is a need for adjunctive therapies to complement and improve treatment outcomes. This study aimed to evaluate the efficacy of locally delivered metformin (MF) 1% gel as an adjunct to SRP in treating severe chronic periodontitis. Materials and Methods: A total of 36 volunteers were randomly assigned to two treatment groups, namely, SRP plus placebo gel and SRP plus 1% MF gel. Clinical parameters such as pocket probing depth (PD), clinical attachment level (CAL), and gingival recession (GR) were recorded at baseline, 2, and 4 months. The data were analyzed using independent T-tests, one-way, and repeated measures analysis of variance (ANOVA) using SPSS 24 software. Results: All groups exhibited improvements in periodontal parameters such as PD and CAL. While the mean reductions in PD and CAL were not statistically significant after 3 weeks of treatment between the two groups (P=0.193), the MF group demonstrated significantly greater improvements in PD, measuring 3.49 mm compared to 1.87 mm in the control group (P=0.007), as well as in CAL, which measured 2.98 mm versus 1.72 mm in the control group (P=0.014). Conclusion: The adjunctive use of locally delivered 1% MF gel could stimulate a significant reduction in PD and increases in CAL compared to the placebo gel, while there was no GR resulting from the local delivery of the drug. This suggests that the MF gel may offer benefits in the treatment of severe chronic periodontitis by enhancing periodontal healing without inducing GR.
A Short Report on the Effectiveness of Edge Taper Platinum and XP-3D Shaper for the Reduction of Enterococcus faecalis Count in the Root Canal System: An Ex Vivo Study
Authors: Moaveni Hanie , Ghahari Parastou , Behrad Samira , Mirmohammadkhani Majid , Rashmee Sobhan , Teimoori Somayeh
Published: September 2024

Background: Intracanal microorganisms are the main cause of radicular lesions and, therefore, should be removed from the root canal system. Enterococcus faecalis is a resistant bacterium isolated from 30%–90% of endodontically-treated teeth, commonly chosen for in vitro studies on endodontic treatment methods. Different methods have been suggested for removing this bacterium from the root canal system, while none have been approved as the gold standard method. This study aimed to compare the effectiveness of Edge Taper Platinum and XP-endo® shaper rotary files in reducing the number of E. faecalis in the root canal system. Methods: In this ex vivo study, 58 single-rooted single-canal teeth were immersed in formalin for 1 hour, stored in 0.9% saline, and randomly divided into positive control (n=4), negative control (n=4), platinum (n=25), and shaper (n=25). E. faecalis was injected into the root canals of all groups, except for the negative control group. The teeth were then incubated in a CO2 incubator for 24 hours. Primary samples were collected, and the root canals were instrumented using the XP-endo® shaper and Edge Taper Platinum. Secondary samples were collected and cultured, and the number of colonies was counted after 24 hours of incubation. The data were analyzed using the Kruskal-Wallis and Mann-Whitney tests at a P<0.05. Results: A significant difference was observed for the reduction of the E. faecalis colony count in 87.79%, 97.83%, and 14.11% of the XP-endo® shaper (87.79%), Edge Taper Platinum (97.83%), and positive control (14.11%) groups (P<0.05). Conclusion: Both XP-endo® shaper and Edge Taper Platinum files with equal apical sizes effectively reduced the number of E. faecalis colonies in the root canal system. Edge Taper Platinum with a greater taper was more effective.
Antimicrobial Efficacy of Carbonated Hydroxyapatite Against Streptococcus mutans, Enterococcus faecalis, and Candida albicans: An In Vitro Study
Authors: Priyadharshini S.Swathi , Ragavendran Chinnasamy , Sherwood Anand , Piriyanga Rathna
Published: September 2024

Background: Dental caries commonly lead to pulp infection, necessitating vital pulp therapy (VPT) to protect the health of the pulp tissue. Effective pulp-capping materials, including those with antimicrobial properties, are crucial for successful VPT. This study aimed to evaluate the antimicrobial efficacy of carbonated hydroxyapatite (CHA), a novel pulp-capping material, compared to frequently used materials, against Streptococcus mutans, Enterococcus faecalis, and Candida albicans. Methods: CHA was synthesized at three concentrations (0.05 M, 0.1 M, and 0.5 M) and compared with mineral trioxide aggregate (MTA). Antimicrobial efficacy was evaluated using the agar diffusion method. Zones of inhibition were evaluated after 24 hours of incubation. A one-way analysis of variance (ANOVA) and post hoc tests were used for the statistical analysis. Results: All materials exhibited antimicrobial activity against the tested microorganisms, with CHA at 0.1 M concentration demonstrating the highest efficacy against E. faecalis and C. albicans. MTA and CHA at 0.5 M concentrations showed strong activity against S. mutans. According to statistical analysis, significant differences were found in antibacterial activity among the tested materials (P<0.0001). Conclusion: CHA, particularly at 0.1 M concentration, demonstrated significant antimicrobial efficacy against S. mutans, E. faecalis, and C. albicans, suggesting its potential as a pulp-capping agent. Further research is warranted to explore its clinical applicability in VPT.
Magnetic Resonance Imaging Study of Paranasal Sinuses Dimensions According to Age and Gender
Authors: Yousefi Faezeh , Farhadian Maryam , Rahimi Sima
Published: September 2024

Background: Considering the importance of paranasal sinus anatomy in treatment planning and related surgeries, the present study aimed to investigate the changes in the dimensions of paranasal sinuses according to age and gender by magnetic resonance imaging (MRI). Methods: MRI images of 310 patients, including 200 women and 110 men aged between 10 and 70 years old, were included in the study. The depths of all paranasal sinuses and the width of the left and right frontal sinuses were estimated in the axial plane. In addition, the height of the left and right frontal sinuses in the sagittal plane as well as the width and height of the maxillary and sphenoid sinuses in the coronal plane underwent measurement. All statistical analyses were performed using SPSS 21, and the significance level was considered at 0.05. Results: Except for the width of the right maxillary sinus, the height of the left frontal sinus, and the width and depth of the left sphenoid sinus, a significant relationship was observed between the other dimensions of paranasal sinuses and gender (P<0.05). Only 5 dimensions, including the width of the left and right maxillary sinuses, the height of the left maxillary sinus, the depth of the left frontal sinus, and the depth of the right sphenoid sinus, had significant relationships with age, so that they decreased with age (P<0.05). The highest symmetry was between the left and right maxillary sinuses. Conclusion: The paranasal sinus was different in men and women. Some dimensions of paranasal sinuses had a significant relationship with age. These results can be used in planning prosthetic treatments and performing surgeries with fewer complications.
Unmasking Greenwashing: Mapping Hijacked Medicine Journals to the Sustainable Development Goals
Authors: Dadkhah Mehdi , Hegedűs Mihály , Dávid Lóránt Dénes
Published: September 2024

Purpose: Hijacked journals are journals managed by cybercriminals that mimic the original journal and publish manuscripts without peer review, charging a fee to the author. Although there is literature on hijacked journals, there is a gap in the content of published papers in the hijacked journals. This study aims to analyze the content of published papers in hijacked journals to assess their alignment with various Sustainable Development Goals (SDGs). Methods: About 21 medicine journals have been investigated and about 3300 published manuscripts in them analyzed in terms of SDGs using the text-based analyzing method. Results: The findings indicated that published manuscripts fit in the categories of SDG 01, SDG 03, SDG 11, and SDG 16 where SDG-03 is most dominant. Conclusion: The awareness about the problem of hijacked journals is critical, especially for developing countries, to eliminate the negative effects of these journals. It is the first research that discusses the negative effect of hijacked journals by considering SDGs and sheds light on the phenomenon.
A Blood Pressure Management Protocol Based on the Transtheoretical Model: Designing and Effectiveness Evaluation
Authors: Barzegar Habibeh , Sodagar Sheida , Seirafi Mohammadreza , Farahbakhsh Mostafa , Hashemi Nosrat-Abad Touraj
Published: September 2024

Background. Hypertension is one of the most important public health challenges in the world, and self-care is an essential part of hypertension treatment. The present study aimed to investigate the effectiveness of a blood pressure management protocol based on the transtheoretical model on improving self-care, self-efficacy, and health-related quality of life in patients with hypertension. Methods. This mixed-methods study consisted of two stages that were conducted in Tabriz Health centers in 2022-2023. The first stage was concerned with designing a blood pressure management protocol based on the transtheoretical model. The second stage was centered on a randomized controlled trial (RCT) to evaluate the effectiveness of the designed protocol on increasing self-care, self-efficacy, and health-related quality of life. Thus, 60 people with hypertension were included in the study and were randomly divided into two experimental and control groups. Data was collected via relevant questionnaires in the pre-test stage, immediately after the training (baseline), 2 months after the training in the post-test stage, and 4 months after the training in the follow-up stage. ANCOVA (repeated measures) statistical test was used to evaluate the effect of the intervention at different times. Results. In the patients of the experimental group, the designed protocol sustainably increased the dimensions of self-care over time (P<0.001). Also, this protocol was effective in increasing self-efficacy and health-related quality of life dimensions in the patients of the experimental group (P<0.001). This increase was not observed for the variables of self-efficacy, self-care, and quality of life in the control group (P>0.05). Conclusion. The greatest effect of training based on the transtheoretical model was on the patients’ self-care. Furthermore, with the passage of time in the presentation of education, the effect of the intervention decreased. Therefore, it can be concluded that holding short training sessions continuously to stabilize the behavior change of patients with hypertension is necessary.
Functionality of XVE-inducible system and toxicity assessment of the bacterial PezT toxin in microalga, Messastrum gracile SE-MC4
Authors: Gan Sik Ze , Yeo Chew Chieng , Cha Thye San
Published: September 2024

This study investigated the effects of the heterologous expression of the pezT toxin gene from the bacterium Streptococcus pneumoniae in the green microalga, Messastrum gracile SE-MC4. The microalgae was co-transformed with the pMDC150_35S activator vector (containing the XVE expression cassette) and the pMDC221_pezTGFP responder vector (containing pezT-GFP fusion genes) using Agrobacterium-mediated transformation. The stable transgenic line, M. gracile SE-MC4 (pezT-GFP) was confirmed through antibiotic selection and PCR validation. Upon induction with 17-β-estradiol, GFP signals were observed in the transgenic M. gracile SE-MC4 (pezT-GFP) cells, indicating successful transformation and expression of the transgene cassettes. Furthermore, the functionality and action of the PezT toxin was demonstrated with a significant reduction of 52% in cell viability of transgenic cells, compared to wild-type cells. This finding suggests the potential use of bacterial toxins as a novel approach for harvesting microalgal cellular contents for various microalgae-based biotechnological applications. It also can be a containment system to prevent the accidental release of transgenic microalgae and used for transgenic microalgae selection, as an alternative to antibiotic selection currently widely used.
THE MENTAL REQUIREMENTS IN THE SEAMANSHIP RACE FROM NAVAL PENTATHLON
Authors: A. Abramiuc , C. Ene Voiculescu , V. Ene Voiculescu , H. Croitoru
Published: September 2024

The aim of this research is to highlight the role of mental preparation in optimizing the training of athletes who are part of the naval pentathlon team.
Identifying the mental demands generated by the programmed training process in order to acquire a higher motor baggage. Following the implementation of the training program proposed for the above-mentioned research, we obtained a significant improvement in motor skills due to the implementation of the mechanisms proposed by us, which acted on the mental demands that appeared during the preparation period for the seamanship race
IS PASSIVE BREAK A PERFORMANCE FACTOR IN FEMALE TEAM HANDBALL?
Authors: C. Gheorghe , C. Mereuță
Published: September 2024

The objective of our research is to obtain an informed opinion from the coaches in Romania, starting from the assumption that a passive break is effective only after the end of the effort. As a research tool, we used the opinion questionnaire. The data were analyzed for normality and then expressed by the mean, minimum, and maximum values. The degree of correlation (rho) between the studied parameters was appreciated by calculating the Spearman correlation coefficient. A value of the coefficient of statistical significance p <0,05 was considered significant. At the same time, we determined the internal consistency of the research tools by using the Alfa Cronbach coefficient for the Likert scale applied to our questionnaire. Our study concludes that Romanian coaches somehow agree with the effects of passive breaks, but they are not entirely convinced that these effects would exist.
THE IMPACT OF REHABILITATIVE EXERCISE ON FUNCTIONAL RECOVERY IN SEVERE BURN PATIENTS
Authors: A. Toma , D. Voicu , C. Popazu , C. Gheorghe , M. Enescu D.
Published: September 2024

Severe burn injuries in children, particularly those affecting more than 30% of total body surface area (TBSA), lead to profound physiological and psychological challenges that significantly impact their long-term recovery. This review focuses on pediatric studies that highlight the role of structured rehabilitative exercise, including resistance and aerobic training, in improving physical function, muscle strength, lean body mass, and cardiorespiratory fitness in children recovering from severe burns. Findings suggest that early introduction of rehabilitative exercise significantly enhances functional outcomes, reduces the need for corrective surgeries, and promotes psychological well-being. The benefits of exercise extend beyond the initial recovery phase, with long-term follow-up data indicating that improvements in muscle mass, strength, and aerobic capacity are sustained for months post-intervention. These findings support the integration of rehabilitative exercise into standard pediatric burn care to optimize recovery outcomes and improve the quality of life for pediatric burn survivors.
Taşınabilir Bir Elektrikli Kanallı Fan Test Standı Geliştirilmesi
Authors: Kara Emre , Özyürek Mustafa Çağatay , Gülseren Gamze , Hayta Ünal
Published: September 2024

Bu çalışmanın amacı, elektrikli kanallı bir fanın (EDF) farklı güç oranlarında verdiği itkileri test etmektir. Nozul girişine takılan iki servomotorun hareketiyle 3°, -3°, 6°, -6° açılarında itki yönlendirmesi yapılmıştır. Bu çalışma ile EDF motorların performans kapasitesinin belirlenmesi de amaçlanmıştır. Yapılan çalışmada, EDF motora güç verildiğinde, EDF üzerine yerleştirildiği kızaklı mekanizma sayesinde rahatça hareket edebilmekte ve ürettiği itki, yük hücresi vasıtası ile akış yönünde ölçülebilmektedir. Çalışmamızda geliştirilen test düzeneğine farklı çaplardaki EDF’lerin takılıp çıkarılması mümkündür. Hesaplamalı akışkanlar dinamiği (HAD) analizleri, daimi akış için farklı dönüş hızlarında elde edilmiştir. Ana çıktılar olan z-yönündeki itki değerleri açılı nozul senaryolarında kaydedilmiş ve grafik halinde verilerek görselleştirilmiştir. Ayrıca YZ düzleminde hız kontürleri ve üç boyutlu yolak çizgisi tüm akış alanı için hız değerlerine göre HAD analizler sonucunda gösterilmiştir. Nominal itki değerleri ve standart sapmaları farklı güç yüzdeleri için test edilen açılarda verilmiş ve aynı grafik üzerinde HAD analizi sonuçları karşılaştırma amacıyla gösterilmiştir. İtki kuvvetlerinin ölçümü sonucunda, güç yüzdesi arttırıldıkça orantılı bir şekilde itki değerinin artmakta olduğu gözlenmiştir. Deneysel sonuçlarla HAD analiz sonuçları birbirleriyle tutarlı ve yakındır. Elde edilen deneysel değerlere lineer (doğrusal) regresyon yapılmış ve “regresyon katsayısı” 1’e yakın elde edilmiştir. Bu durum güç yüzdesi ile itki değerleri arasında oluşturulan doğrusal regresyonun uyumlu olduğunu göstermektedir.
Eristalinus taeniops (Wiedemann, 1818) (Diptera: Syrphidae), an exotic flower fly rapidly spreading in South America: A review
Authors: Kondo Takumasa , Rosero Robert , Gaviria Jackeline
Published: September 2024

Information on the world distribution of E. taeniops and a distributional map of the species in the New World is presented based on available literature, specimens collected in the present study, and citizen science reports. A morphological diagnosis and background on the biology of the species are provided based on photographs and published literature. We briefly discuss how E. taeniops may be spreading in South America via airports and seaports.
HALOTERAPİ - TUZ TERAPİSİ: SOLUNUM YOLU HASTALIKLARININ TEDAVİSİNDE TAMAMLAYICI BİR YÖNTEM
Authors: Sancar Tekin , Alma Mehmet Hakkı
Published: September 2024

Tuz, sağlığa faydaları ve tedavi edici etkisi nedeniyle binlerce yıldır dünyanın farklı bölgelerinde farklı kültürler tarafından kullanılmaktadır. Haloterapi, halojeneratör adı verilen özel ekipmanlarla ortamlarda sağlanan kuru bir tuz terapisidir. Son yıllarda haloterapi dünya çapında giderek daha fazla insanın güvenini kazanmış ve birçok ülkede hızla yayılmaya başlamıştır. Terapiden elde edilen olumlu sonuçlar bir yıldan fazla sürmektedir. Diğer fizik tedavi yöntemleri ve farmakolojik terapi ile kombine edilebilmesi, haloterapiyi hafif ve orta dereceli bronşiyal astım, kronik obstrüktif bronşit, post-pnömoni durumları ve diğer çeşitli solunum ve cilt hastalıklarında tercih edilen bir tedavi haline getirmektedir. Haloterapinin cilt üzerindeki iyileştirici ve kozmetik etkileri bilimsel çalışmalarla doğrulanmıştır. Bu tedavinin rahat bir ortamda gerçekleştirilmesiyle birlikte oluşan önemsiz yan etkileri, hastaların psiko-duygusal durumu üzerinde de faydalı bir etkiye sahiptir. Bu araştırmanın temel amacı, solunum yolu hastalıklarının tedavisinde tamamlayıcı bir yöntem olarak haloterapinin faydalarını tartışmaktır.
Proposing trauma-informed practice and response in policing: A social innovation narrative for reforming responses to child sexual abuse and exploitation
Authors: Humphries Kelly-Anne M. , McGillivray Cher J. , Christophersen R.A. Line
Published: September 2024

Shifting towards trauma-informed practice and response (TIPAR) in law enforcement is crucial for reforming policing practices to reduce re-victimization among survivors of child sexual abuse and exploitation (CSA&E). Studies show that one in four Australians experience childhood sexual abuse (Haslam et al., 2023) highlighting the urgent need for effective law enforcement interventions. Police, as primary responders for children in the criminal justice system, experience significantly higher rates of stress and post-traumatic stress disorder (PTSD) compared to the general population. Current policing cultures often use ad hoc procedures that struggle to meet the unique needs of CSA&E victims. TIPAR advocates for comprehensive police training and trauma-informed policies to address these gaps. By integrating TIPAR consistently across law enforcement agencies (LEAs), this approach aims to enhance case progression, build police legitimacy, foster trust, and increase victims’ engagement with justice processes. Implementing TIPAR is expected to enhance compassion satisfaction among officers, improve staff retention, reduce organizational costs, and create a justice system that better supports CSA&E survivors and their families. This holistic approach is crucial for addressing the significant under-reporting of sexual offences, where over 85% fail to progress to prosecution (Attorney Generals Department, 2023). Piloting TIPAR is essential to gather empirical data supporting government adoption of minimum standards for trauma-informed practices in legislation, ensuring that TIPAR principles are embedded in all LEA activities. This Social Innovative Narrative aims to explain the benefits of implementing TIPAR within LEAs, advocating for a more compassionate and effective response to trauma within law enforcement.
“Policing at the speed of trust”: Interacting with trauma-impacted youth
Authors: Molla Tebeje
Published: September 2024

Young people living on the fringes of society face heightened vulnerability and trauma that profoundly impact their ability to trust others. When trauma-impacted youth, such as those exposed to pervasive racism or with refugee backgrounds, have faced unfair treatment by authorities in the past, they often develop a deep distrust towards law enforcement officers. Consequently, interactions with police can become fraught with fear and aggression as past experiences of injustice resurface, triggering defensive and adverse reactions. Bearing these dynamics in mind, the article underscores that socially just policing requires a commitment to trauma-responsive engagement that nurtures trust by prioritizing safe interactional environments based on tactfulness and co-regulation. Trustful engagement prevents re-traumatization, promotes effective communication and addresses disparities in policing outcomes.
Aerobik dan Jus Tomat Dapat Menurunkan Tekanan Darah Penderita Hipertensi di Klinik Kartika 0730 Gunung Kidul Yogyakarta
Authors: Latifah Itsni Azizatul , Salim Nasiatul Aisyah
Published: September 2024

Introduction: Hypertension is recognized globally as a major public health problem. Antihypertensive drugs are effective in lowering blood pressure, but the achievement rate is still low worldwide. Although antihypertensive drugs can control blood pressure, low physical activity is a risk factor for hypertension mortality. Therefore, increasing physical activity through aerobic exercise is a recommendation for complementary therapy for the treatment of hypertension. Simultaneous implementation of moderate to high intensity exercise and weight loss through diet has been identified to be able to lower blood pressure more. And the content in tomatoes can lower blood pressure. Research Objective: This study aims to determine the effect of aerobics and the administration of tomato juice on reducing blood pressure in hypertensive patients at the Kartika Clinic 0730 Gunung Kidul Yogyakarta. Research Method: This research is a quantitative experimental study with a one group pretest-posttest design. The sample is 30 people with purposive sampling technique. The intervention was carried out 4 times for 2 weeks. Aerobic exercise is carried out for 30 minutes and 150 cc of tomato juice without sugar. Data analysis used paired t-test. Research Results: The results of the analysis show that there is an effect of aerobics and tomato juice on reducing blood pressure in hypertensive patients at the Kartika Clinic 0730 Gunung Kidul Yogyakarta. Conclusion: Aerobic exercise and giving tomato juice can reduce blood pressure in hypertension sufferers.
Measurement and Analysis of Noise Levels from Loudspeakers on Public Transportation in Kupang, East Nusa Tenggara
Authors: Wellem Theophilus , Nataliani Yessica , Manongga Danny , Hendry Hendry , Utomo Darmawan , Timotius Ivanna K. , Kameo Daniel D. , Lasso Aldi , Weku Winsy C.D
Published: September 2024

The government is very concerned about the threshold value of human hearing that causes permanent noise-induced hearing loss (NIHL), such as noise caused by public transportation (bemo) in Kupang. This research aims to increase the awareness of the bemo user in Kupang to prevent hearing loss due to noise from bemo audio devices. Noise measurements due to public transportation are usually carried out outside the vehicle, for example, on the street, but in this study, measurements were carried out inside the vehicle (bemo). Data was obtained from (1) Data on sound intensity in public transport taken manually using a Sound Pressure Level (SPL) meter and (2) Data on the working hours of the drivers taken manually by asking how long they drive in a day. The results of  of each route and the average of  of eight routes showed a sound intensity above the threshold set by the government, i.e., 70 dB. Routes 1 and 3 are bemo routes that need attention because they have maximum sound intensity of more than 100 dB and are included in the Very Loud category. Meanwhile, the other routes are included in the Loud category. Furthermore, the average time a driver stays in a bemo daily is 13.5 hours, which concluded that all drivers are at risk of hearing loss. Therefore, special attention is needed from the government because this can result in driver hearing loss.  
Keywords: Bemo; Kupang; Noise-induced hearing loss; Public transportation; Sound intensity
Gippsland Migration Recruitment & Retention Charter. Collaborative Evaluation and Research Centre.
Authors:   Collaborative Evaluation and Research Centre, Porter Joanne , My Sambath , Simic Megan , Coombs Nicole , Miller Elizabeth , Soldatenko Daria , Abdelkader Amany , Hualda Luis
Published: September 2024

This Charter is a commitment to shared values and principles for the recruitment and retention of Migrants in Gippsland. The Charter provides its supporters with a clear outline of strategies and approaches suggested by all those that participated in the development of the Charter through the voices of Migrants
The problem of distinguishing between general and special grounds for challenging transactions of an insolvent debtor
Authors: Denisovsky M. O.
Published: September 2024

The article presents the results of the research of the problem of differentiation of general and special grounds for challenging debtors’ transactions in bankruptcy cases. Based on the analysis of legal acts, materials of court practice and positions of the Supreme Court of the Russian Federation, the author has established specific features of law enforce ment of general and special (bankruptcy) grounds for challenging transactions of an insolvent debtor. On the example of judicial practice materials the article argues the author’s position that the problem of application in practice of these grounds remains relevant for the courts due to the fact that the legislation does not reveal sufficient criteria for differentiating these grounds. Despite the impossibility of applying general and special grounds simultaneously, cases of their joint use arise in court practice. These aspects give rise to legal uncertainty. In this connection, more detailed regulation of specific features and grounds for application of bankruptcy grounds for challenging a debtor’s transactions is required. Prospects of the present study consist in substantiation of proposals on introduction of amendments and additions to the Federal Law dated October 26, 2002 No. 127-FZ “On Insolvency (Bankruptcy)” taking into account the analysis of judicial practice materials.
Zero Energy Buildings and Features of their Arrangement
Authors:   Georgian Technical University, Kopalian Alex , Grdzelishvili Mamuli ,   Georgian Technical University, Goderdzishvili Solomon ,   Georgian Technical University
Published: September 2024

. Zero heating energy buildings are high-class energy-efficient buildings that do not require a heating system to maintain the temperature regime. Setting up buildings without a heating system provides the opportunity to save millions of tons of fossil heating and reduce the emission of CO2 into the environment. The influence of the thermal protection conditions of the surrounding constructions of the buildings and the use of recuperative ventilation systems on reducing the thermal loads of the buildings and providing a comfortable environment is discussed. Based on the analysis of the temperature-humidity regime of the enclosing constructions made of different types of building materials, the thickness of the thermal insulation layer of this construction is determined, which provides such optimal parameters for zero-energy heating houses, such as: heat transfer coefficient, the normed ratio between the indoor air and the inner surface of the outer wall, taking into account the sanitary-hygienic standards, temperature difference and the maximum allowable relative humidity in the thickness of the wall. A unified heat supply scheme for zero-energy houses for heating, ventilation and hot water supply using a ventilation recuperator is discussed.
Vibrational Spectroscopy of Nanobiosystems and Concept of Resonance Therapy
Authors:   Georgian Technical University, Kervalishvili Paata
Published: September 2024

The possibility of vibration always exists wherever there is periodic and repeated movement of a particle about a position of equilibrium or balance. This process is also natural for nanosized bioparticles of enveloped, positive-strand RNA viruses which infect amphibians, birds, and mammals and now known as coronaviruses. Coronaviruses are important human and animal pathogens. In late 2019, the new coronavirus was identified as the cause of a cluster of pneumonia cases in Wuhan, a city in China's Hubei province. It spread quickly, leading to an epidemic across China, followed by an increase in cases in other countries around the world. This study aimed to explore nanobiospectroscopy research and technology in order to provide a theoretical, computer modelling and experimental basis for development of methods and tools of identification of specific vibrational frequency of viruses and then their resonance therapy.
Interstate Agreements on Temporary Legal Employment Abroad: Opportunities and Challenges
Authors:   Georgian Technical University, Chubinidze Natalia
Published: September 2024

The management of migration is one of the pressing and significant issues not only for our country, but also internationally. The multi-component nature of migration processes, which includes many aspects of public, economic, and political dimensions, deserves special mention. The article focuses on one of the components of labor migration, such as interstate agreements on temporary legal employment abroad. Similar agreements are made between the two partner states in accordance with the demands/needs in the labor market and to eliminate the existing imbalance regarding specialists with specific qualifications. These agreements have become particularly relevant during the last decade, as the need to attract qualified personnel of various specialties has been highlighted in developed economies due to factors such as emigration and growing economic development. These agreements are considered one of the means of preventing illegal migration, offering an effective opportunity to protect the interests of both sending and receiving countries, as well as the migrant.
Software Packages for Data Analysis
Authors:   Georgian Technical University, Kurashvili Guguli , Beridze Tamar ,   Georgian Technical University, Beridze Lika ,   Georgian Technical University, Devidze Tamar ,   Georgian Technical University
Published: September 2024

An important part of scientific work is the research component, the processing stages of which, in addition to theoretical knowledge and practical skills, require optimal use of time, which directly depends on knowledge and access to modern technologies. Computer technology plays a critical role in data processing by enabling efficient storage, retrieval and analysis of large volumes of data using various statistical methods. The article discusses proven computer programs for data processing and analysis. Computer technology plays a fundamental role in enhancing the capabilities of data processing software, which helps researchers conduct more efficient, accurate and reliable analysis. As studies show, due to the lack of appropriate knowledge, data analysis is, unfortunately, available to a small number of scientists and students.
INTERROGATING THE REHABILITATION PROGRAMMES FOR INMATES IN OKAKA PRISON
Authors: EKPEYONG ALFRED S. , EBITIMI AMBAKA ALEX
Published: September 2024

In modern correctional settings, the challenge of effectively rehabilitating inmates and facilitating their successful reintegration into society looms large; necessitating a comprehensive understanding of the dynamics at play. The study investigates the effectiveness of rehabilitation programmes for inmates at Okaka Prison in Bayelsa State, Nigeria, with a focus on the impact of these programs on inmates’ reintegration into society. The relevance of Labeling Theory is discussed in understanding inmates’ criminal behaviours and their challenges in societal reintegration. Adopting a cross-sectional survey design, the research includes data from 275 inmates and 21 key informant interviews, utilising multi-stage sampling techniques. Data analysis, using the Chi-square test of independence and SPSS version 21.0, highlights the significant impact of vocational courses, counselling, and educational training on inmates, emphasizing their importance over parole, probation, punishment, and moral education. Positive staff-inmate relationships are also noted, contributing to successful rehabilitation. Recommendations include expanding ICT-driven vocational courses, promoting gender-inclusive training, and fostering positive warder-inmate relationships for enhanced rehabilitation outcomes and societal integration.
Molecular detection of high-risk papillomaviruses and vaccination status in normal cytology in Congo
Authors: Ngombe Mouabata Dorine Florence Luthera , Boumba Anicet Luc Magloire , Iloukou Mayakia Patrina Joseph , Massengo Norvi Rigobert Bienvenu , Takale Ragive Parode , Moukassa Donatien , Ennaji Moulay Mustapha
Published: September 2024

Objective: The aim of this study was to identify the molecular prevalence of high-risk HPV infection and the distribution of genotypes present in normal cytology, as well as to determine the vaccination status of our study population.
Methods: 110 cervical samples were taken from individuals, and 1 ml of each sample was added to the Xpert HPV cartridge in the sample compartment before it was placed in the Cepheid GeneXpert system. Detection was performed simultaneously via amplification of the E6 and E7 genes in five fluorescent channels (HPV16, HPV18/45, HPV31/33/35/52/58, HPV51/59, and HPV39/56/66/68a).
Results: 36/110 (33%) of all samples tested were positive for HPV DNA. The predominant genotypes were HPV16 (12.7%) and other pooled HR-HPV types (8.2%). All women who received the Gardasil-9 vaccine (3.6%) had HPV, and infection was associated with travel outside Africa. 96.4% of the screened individuals had not received any HPV vaccine.
Conclusion: Our research confirms a widespread HR-HPV infection in our population and extends the importance of studies on the molecular prevalence of HPV, particularly in women with normal cytology and apparent good health, in view of the cruel lack of public awareness of HPV infections.
The effect of sodium deoxyribonucleate with iron complex on the expression of surface markers of MT-4 cells infected with human immunodeficiency virus type 1 (HIV-1) (Retroviridae: Primate lentivirus group)
Authors: Nosik Dmitry N. , Kalnina Lyudmila B. , Selimova Lyudmila M. , Kaplina Ellie N.
Published: September 2024

Introduction. The persistence of immune dysfunction during therapy has serious consequences for the health of HIV-infected people. Therefore, an important direction is the search for drugs that can reduce the inflammatory potential of the immune system and serve as an additional component of antiviral therapy.
Aim ‒ to study the effect of the immunomodulatory drug Sodium deoxyribonucleate with iron complex (DNA-Na-Fe) on the expression of activation markers in MT-4 cells infected with HIV-1.
Materials and methods. Expression levels of CD4, CD28, CD38, CD62L and HLA-DR proteins on the plasma membrane were measured in cells. To assess viral activity, the p24 protein was quantified by ELISA.
Results and discussion. The two cell variants with different replicative activity were analyzed. Control cells, cells with DNA-Na-Fe, infected cells and infected cells with DNA-Na-Fe were tested. Based on the results obtained, it can be concluded that antiviral activity of the drug in MT-4 cells infected with HIV-1 is associated with immunomodulatory activity that enhances the expression of membrane proteins CD4, CD28, CD38 and CD62L. Diversity in the effect of DNA-Na-Fe on the studied surface proteins expression in two cell lines indicates that they depend on the characteristics of the combined molecular biological processes occurring in cells. And the increased effects observed in a system with changes in replicative activity assumes its active participation in virus replication at the stages of virus penetration and budding.
Conclusion. Studies have shown that DNA-Na-Fe has antiviral and immunomodulatory activity.
Seropositivity of West Nile virus among acute febrile patients in Ilorin, Nigeria
Authors: Odebisi-Omokanye Mutiat Busayo , Suleiman Muhammed Mustapha , Sulaiman Mariam Kehinde , Atolagbe Sidiq Abubakar
Published: September 2024

Introduction. West Nile Virus (WNV), a member of Flaviviridae family, is one of the most widely distributed arboviruses in the world. In developing countries like Nigeria, fever resulting from the WNV infection is often presumptively ascribed to malaria or typhoid due to misdiagnosis and low-level awareness of the viral infection. This study determined the prevalence of WNV IgM and IgG antibodies among febrile patients in the Ilorin metropolis.
Materials and methods. A total of two hundred (200) blood samples were collected from consenting patients and each serum was screened for anti-WNV IgM and IgG antibodies using indirect enzyme-linked immunosorbent assay (ELISA). Statistical correlation and logistic regression analysis were conducted.
Results. Overall, 6% (12/200) anti-WNV IgM seropositivity rate was recorded amongst the acute febrile patients with higher prevalence (6.30%) in females than in males (5.45%). Anti-WNV IgG positivity rate of 52% (104/200) was recorded, with 50.67% positivity rate in males and 38.95% in female participants. The convalescence phase posited by the 5.4% (11/200) co-detection of anti-WNV IgG and IgM antibodies among the participants was recorded. A statistical correlation was noticed with the age and religion of respondents to WNV serological positivity while gender, occupation, use of mosquito nets and formal education had no positive correlation at p 0.05. However, based on odd ratio at 95% CI and logistic regression coefficients, the evaluated risk factors such as blood transfusion, residency, malaria parasite, and proximity to stagnant water and bush were significant to anti-WNV IgG and IgM positivity.
Conclusion. The findings of this study show the circulation of WNV in the study area. There is an urgent need for clinicians/physicians to include screening for the West Nile virus in cases of febrile patients before the commencement of treatment.
Molecular Study of Varicella zoster virus in Cerebrospinal Fluid from Stroke Patients of Thi-Qar province
Authors: Salim Zinah Fadhil , Hamad Bushra Jabbar
Published: September 2024

Introduction: Varicella zoster virus (VZV) is a type of alpha-herpesvirus that specifically targets the nervous system. The initial infection, typically occurring during childhood, results in varicella (commonly known as chickenpox), after which the virus enters a dormant state in cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia throughout the entire neuroaxis.
Aim of the study: Molecular and genetic studies of viruses are an important tool for virus development and identifying viral treatments to combat the diseases. The aim of the study was to determine the whole ORF4 sequence of the local VZV strains for phylogenetic analysis to determine the variability in the viral sequence.
Material and methods: Ten samples of VZV DNA were subjected to the sequencing of the whole ORF4 region following identification using the PCR method.
Results: Sequences from five samples have been successfully analyzed. All clinical strains were discovered to possess a genome with a length of 124,884 base pairs. The sequences exhibited the occurrence of two distinct mutations, one being a transversion and the other a transition, with the latter resulting in an alteration of the amino acid. A phylogenetic tree was constructed using the maximum likelihood method based on the sequences of five nucleotide sequences from clinical samples and nine reference VZV strains. The tree displayed the evolutionary distances between these sequences. The analysis of the phylogenetic tree revealed the presence of five primary clades, with four of them originating from India (isolates S1, S2, S4, S5), while S3 exhibited similarity to a strain from the United Kingdom.
ÍNDICE DE FUNCIONALIDADE BRASILEIRO
Authors: Fonseca RIBEIRO Regina Céli , Vasconcelos de Oliveira VILELA Lailah , VAZ Daniela Virgínia
Published: September 2024

The Brazilian Inclusion Law (LBI) consolidates the definition of disability as a matter of social inequality and not just as a biomedical problem. This definition implies the need for biopsychosocial assessment to identify individuals eligible for reserved places in higher education. In 2024, the Federal University of Minas Gerais (UFMG) implemented a biopsychosocial validation process using the Brazilian Functioning Index (IFBr), a tool expected to become the sole instrument for assessing disability in all public policies. This paper reports on UFMG's experience with training for the use of the instrument and the implementation of evaluation panels, contextualizing its use in relation to the history of the instrument and the procedures adopted at other universities.
ALTAS HABILIDADES/SUPERDOTACIÓN EN URUGUAY
Authors: PÉREZ-BARRERA Susana Graciela , ARBELO-MARRERO Leticia Yaquelin
Published: September 2024

The paper presents a descriptive study of the Uruguayan educational reality related to gifted students from an educational, historical, and critical view. Methodologically, a documental analysis of national educational regulations, documents and websites published by national governmental and international agencies, press news and the report on the statements of gifted persons identified by our Grupo de Investigación en Altas Habilidades/Superdotación (GIAHSD), linked to the School of Educational Sciences of Universidad de la Empresa (UDE), their families and teachers, analyzed by the Content Analysis technique (Bardin, 2016). The results show an almost complete absence of educational regulations considering High Ability/Giftedness (HA/GT), scientific publications on the topic, and teachers' training to identify gifted persons. It was also found a poorly representative advocating movement and an important incidence of myths and popular beliefs that keep this population invisible. On the other side, the interference of healthcare professionals having no specific knowledge of HA/GT and use to confound this behavior with pathologies and disturbances, wrongly diagnosing it is concerning, and causes an increasing medicalization inevitably extended to the educational field, which feels not capable of identifying and served these students. As positive actions, we should outline the 255-hour training course offered to 250 Uruguayan teachers by the General Agency of Initial and Elementary Education, dictated by members of GIAHSD, and the first Mastership program in High Ability/Gifted Education within the region offered by UDE.
KNOWLEDGE ON HIV/AIDS AMONG NURSING STUDENTS IN BANGLADESH
Authors: ABM Alauddin Chowdhury , Khatun Shewly , Haque Md. Imdadul , Muhammad Faisal , BakiBillah Abul Hasan
Published: September 2024

Study shows that understanding regarding HIV/AIDS among the Bangladeshi nursing students is not up to the mark. This investigation planned to evaluate the knowledge of student nurses with regards to AIDS in Bangladesh. The study was a cross sectional descriptive study conducted among the students of 1st year, 2nd year and 3rd year in Nursing Institute, Mitford Dhaka, Bangladesh in 2014. Hundred and fifty nursing students were selected following systematic sampling technique and data were collected with a self-administered semi-structured questionnaire under specific guidance, who met the inclusion criteria. Knowledge of the nursing students regarding the HIV/AIDS was not satisfactory. More than two-fifth of the participants didn’t know that the proper use of a male condom could prevent transmission of the HIV/AIDS virus through sexual contacts. Only 4.7% of the respondents reported that they receive knowledge on HIV infection from school. This study found strong association between level of knowledge on HIV and attendance of nursing students to training program on HIV infection. Although the level of awareness is expected to be high, misunderstandings about the means of disease spread were common among the nursing students.
Is the Liraization Strategy of the Central Bank of Republic of Türkiye Successful?
Authors: Eren Bekir
Published: September 2024

This study aims to analyze the success of the “Liraization Strategy” introduced by the Central Bank of Republic of Türkiye. Liraization, the main component of unusual monetary policy, officially implemented from the beginning of 2022 to the second half of 2023. Using the policy texts of the Central Bank and literature review; regulations, tools and targets of the liraization strategy has been figured out. To evaluate the success of liraization, realization of the goals has been examined employing real data and graphical analysis. The outcomes indicate that the strategy has failed in price stability and financial stability. In addition, the current account balance has worsened. On the other hand, rising the share of TL in balance sheets of companies and bank via intensive regulations has caused to high cost on budget and the Central Bank. Also, market interventions to support TL have disrupted the market mechanism and relative prices; and have increased the inequality in income distribution.