bluuebunny/crossref_metadata_2025 huggingface dataset:
AFRODİT DAVASI: İkinci Dünya Savaşı Yıllarında Türk Basınında Sansür Uygulamasına Bir Örnek
Authors: SEMİZ Yaşar , TOPLU Güngör
Published: July 2022

Malatya Milletvekili Nasuhi Baydar Eylül 1939’da Fransız yazar Pierre Louys'in "Afrodit" isimli romanını Türkçeye çevirmişti. Türkçeye çevrilmesinin ardından roman, bazı okuyucular tarafından “müstehcen” olduğu ve Türkiye’deki ahlaki değerlere zarar vereceği gerekçesi ile şikâyet edildi. Polis tahkikatından sonra konunun İstanbul savcılığına intikal etmesiyle Afrodit davası başladı. Mahkeme, eserle ilgili şehir tarihi yazması ile ünlenen İbrahim Hakkı Konyalı’yı bilirkişi tayin etti. Konyalı’nın, Afrodit kitabının müstehcen olduğu konusunda görüş bildirmesi üzerine savcılık, kitabın toplatılmasına karar verdi. Kitabın yayımcısı Semih Lütfi Erciyas ile basımcısı Kenan Basımevi sahibi Kenan Dinçman hakkında dava açıldı. Yargı süreci devam ederken davaya ilişkin yazılarından dolayı Yunus Nadi, Necip Fazıl, Vala Nurettin, Şevket Rado, Halil Lütfi Dördüncü, Sabiha ve Zekeriya Sertel, Ethem İzzet Benice gibi yazarlar hakkında da davalar açıldı. Başta Cumhuriyet gazetesi olmak üzere birçok gazetede kalem kavgaları yaşanmaya başladı. Gelişmeler edebiyat ve yayın dünyasında yakından takip edildi. Davanın ilk celsesinde hâkim, söz konusu eserle ilgili uzman görüşü alınması için önce İstanbul Edebiyat Fakültesi öğretim üyelerinden ardından da Milli Eğitim Bakanlığı Talim Terbiye Kurulu üyelerinden oluşturulan heyetlerden eserin müstehcen olup olmadığı ve bir sanat eseri olarak kabul edilip edilemeyeceği konusunda görüş istenmesine karar verdi. Bilirkişiler, romanın müstehcen olmadığı ve bir sanat eseri olduğu konusunda görüş bildirdi. Bu görüşün ardından mahkeme, Afrodit kitabı, onu çeviren yazar, yayınlayanlar ve kitap yüzünden açılan basın davaları hakkında beraat kararı verdi. Karar temyiz edildi ancak temyiz mahkemesi de beraat kararını onayladı.
Rakosi Jarabak Analysis for the South Indian Population - A Cross-Sectional Study
Authors: Sruthi H  , S Aravind Kumar , Arvind Sivakumar
Published: July 2022

Background:

Rakosi jarabak analysis has been proved to be effective in predicting the facial growth pattern, morphological characters, reaction to various orthopedic approaches, and functional alterations. Most of these established cephalometric values are based on average values for the Caucasian population. Whereas cephalometric values vary among different populations and have shown variations among different ethnic groups, gender, and age. The objectives of this paper are to develop Rakosi Jarabak cephalometric norms for the South Indian population and compare the measures to values from other ethnic groups.

Materials and Method:

Facad software was used to track the lateral cephalograms of 100 non-growing patients from the South Indian population who satisfied our inclusion criteria. Nineteen craniofacial parameters of Jarabak’s analysis were measured.

Result:

A comparison between the males and females of the South Indian population showed a significant difference between the three parameters. Comparison of the south Indian male, female values, and overall values with established norms of various ethnic populations showed significant differences among various parameters.

Conclusion:

This study establishes the south Indian ethnic norms for Rakosi Jarabak analysis. The south Indian norms vary from caucasian norms showing significant ethnic .These differences need to be considered when analyzing the cephalogram . These values will help in customizing treatment plans based on ethnic norms.The study concludes that distivariationsnct sets of cephalometric norms should be developed for different ethnic groups in order to aid orthodontists and surgeons in optimising treatment plans based on local norms.
EL DESEMPLEO EN EL ECUADOR EN LA PROVINCIA DE CHIMBORAZO.
Authors: Antun Karen , Guaraca Vero
Published: July 2022

Se discute que Ecuador es un país netamente productor, es decir que el país tiene un importante y único patrimonio cultural base del desarrollo económico, social, cultural y productivo, pero con altas tasas de desempleo, al referirnos a la provincia de Chimborazo que, una provincia rica en producción con tasas de desempleo extremadamente altas el siguiente trabajo propone identificar las consecuencias de dicho problema social y de esta forma poder disminuir la tasa de desempleo por medio de incentivos que les permitan ser emprendedores, para generar oportunidades laborales y económicas. Se llevará a cabo una investigación basada en talleres comunales de investigación, estudios de caso, observación de campo, entrevistas informales etc. Como principales resultados hemos tenido que por cada 45 personas 13 personas no cuentan con un empleo estable y esto se debe principalmente por la falta de educación, falta de plazas de trabajo, falta de experiencia laboral, etc. Como conclusiones primordiales a esta problemática podemos decir que el desempleo ha generado que las personas inicien o establezcan unidades productivas con el propósito de generar ingresos, y de pasar de ser un empleado a ser un empleador, con el transcurso del tiempo el emprendimiento ha se ha constituido como una oportunidad de crecimiento económico de las ciudades y países, generado empleos y la difusión de proyectos e ideas transformadoras de situaciones económicas vulnerables y que se posicionan en el mercado.
ANÁLISIS ECONÓMICO SOBRE LA SOBREPRODUCCIÓN DE LECHE EN ECUADOR 2016-2019
Authors: Agualongo Tisalema Norma Marisol , Lema Guaman Silvia Janneth
Published: July 2022

En Ecuador trabajan 298 mil productores de leche el 80% son pequeños y el 20% se reparten entre medianas y grandes empresas, la producción diaria de leche alcanzó los 6,25 millones de litros de leche, según cifras del ESPAC-2020. El objetivo del presente artículo es analizar los costos de producción y la sobreproducción que ha generado la industria lechera en el Ecuador en los últimos años, donde se identifican variables como el porcentaje de costos que genera para la producción lechera, el precio de venta por litro de leche, comparación de litros de leche producidos por provincias desde el año 2016 al 2019, y el aporte al PIB. Esta investigación se la realizó a través de revisiones bibliográficas y revistas oficiales que nos proporcionó información verídica, de esta forma se obtuvo la información sobre la producción de leche, aportan al PIB del 4%, de igual manera se determinó que existe mayor producción de leche en Chimborazo y Pichincha con 787 mil y 1 millón de litros/ día, cuyo producto no alcanza a ser comercializado de forma eficiente y esto produce perdidas a los pequeños y grandes productores que en algunos casos deben salir a comercializar a precios muy bajos para así poder recuperar un poco de lo invertido en su producción, con esta investigación se concluye que los costos de producción en el Ecuador son muy elevados dependiendo de diferentes factores y no existe una suficiente demanda para poder abarcar toda la leche que se requiere comercializar en el país.
Analisis Perbedaan Kinerja Keuangan Sebelum dan Sesudah Kenaikan Harga Tiket pada PT. Garuda Indonesia (Persero) TBK
Authors: Khoir Miftahul , Kesuma Ali
Published: July 2022

This study aims to determine the differences in financial performance before and after the ticket price increase policy at PT. Garuda Indonesia (Persero) Tbk. in 2016-2019. The technique used in sampling is the purposive sample technique. This research was analyzed using the Du Pont System analysis tool. To test the differences in financial performance using Paired Sample T-test. where the test was carried out using the SPSS application program. The results of the study based on the Paired Sample T-test show that the total assets turnover has differences after the ticket price increase, while current ratio, return on assets, return on equity, return on investment, net profit margin, and debt to equity ratio have no difference after a ticket price increase.
Review the Dimensions of Brand Equity (Study on Community of Users of Federal Brand Motorcycle Engine Lubricants in Sampit Early 2021)
Authors: Sutejo Bambang , Mulyanto Sigit
Published: July 2022

This study aims to determine how the strength of the brand equity of Federal brand motorcycle engine lubricants is seen from the dimensions of brand awareness, brand associations, perceived quality, and brand loyalty. The population in this study is the community of users of Federal brand motorcycle engine lubricants who replace lubricants at a motorcycle repair shop in Sampit. Data was obtained by using a questionnaire which was then analyzed by descriptive analysis. Brand awareness data is measured by percentage calculation, brand association data is measured by the Cochran test, while data on perceived quality and brand loyalty is measured by means. The results of the study show that (1) the dimension of brand awareness of Federal motorcycle lubricants ranks third in the top of mind, second in brand recall, and 4% in brand recognition. Associations related to Federal lubricants are Astra products, lubricants whose quality is tested, durable, and easy to obtain because they are available in various places in Indonesia. Federal lubricant quality perception has a performance level (3.12) lower than the importance level (4.25). From the switcher level brand loyalty to liking the brand, is categorized as good enough as the committed buyer level, it can be seen from the frequency of consumers suggesting and promoting Federal lubricants (3.91), therefore it can be concluded that Federal lubricant brand equity is quite strong.
Pengaruh Kualitas dan Fitur terhadap Keputusan Pembelian pada Smartphone Samsung Galaxy A Series (Study Kasus pada Mahasiswa Universitas Darwan Ali di Sampit)
Authors: Widia Amalia Nur , Rayuwanto Rayuwanto
Published: July 2022

This study aims to determine the effect of the quality and features possessed by smartphones on the purchase decision of the Samsung A Series. The population of this study was Darwan Ali University students and as many as 80 students became the research sample using random sampling. Multiple linear regression analysis will be used because the regression model is free from multicollinearity, normality, and heteroscedasticity. The results of this study indicate that quality and features have a positive and significant effect on purchasing decisions. Quality and features can describe the decision to buy a smartphone by 30.7%.
Pengaruh Harga dan Kelengkapan Produk terhadap Minat Belanja di Mentari Swalayan dimana Kemudahan Belanja di Alfamart menjadi Variabel Moderating
Authors: Rusdawati Rusdawati , Andriyati Yuli
Published: July 2022

This study was purposed to determine the effect of price and product completeness on shopping interest in Mentari Swalayan with the easeof shopping as a moderating variable. As for what is presented as a population is all customers who have shopped at Mentari Swalayan and Alfamart. The sampling method used was convenience sampling, in which the total amount of respondents was 112. The research instrument is a questionnaire using a Likert scale to collect data about price and product completeness variables and purchase desire, as well as the ease of shopping as a moderating using the HRA (Hierarchical Regression Analysis) method. The results of this study showed that price, product completeness partially and simultaneously have a positive significant effect on purchase intention. According to the result of data analysis, the ease of shopping does not moderate the effect of price and product completeness on shopping interest.
Penerapan Penggunaan Aplikasi Akuntansi pada Usaha Mikro Home Industri (Studi Kasus Krupuk Ikan Haruan Nurhayati)
Authors: Hayati Sari
Published: July 2022

Accounting is an information system that produces reports to interested parties regarding financial activities and business conditions. There are still many micro-enterprises as a support for the economy in Indonesia that have not yet implemented accounting applications in the preparation of financial statements to carry out all their activities. This study aims to determine the application of accounting applications and their benefits in the Haruan fish cracker business. The data used are primary and secondary obtained from interviews and evidence of recording during the 2020 period. The data analysis technique is qualitative descriptive. Constraints faced in implementing accounting applications include educational background, having never attended training in the application of accounting applications and internet networks. The results of this study are that the Haruan Fish Krupuk Business has prepared financial statements using the SME accounting application. The application greatly facilitates financial management, is time efficient, and is easy to control.
Reaksi Investor Pasar Modal terhadap Event Pengumuman Paket-Paket Kebijakan Ekonomi Jokowi-Jusuf Kalla
Authors: Handayani Revita Dwi , Kesuma Wendy
Published: July 2022

The purpose of this study is to examine whether the Economic Policy Package issued by the Government of President Jokowi-Jusuf Kalla can be used to see the reaction of Capital Market Investor that can be seen from abnormal returns received by investors. The abnormal return calculation method used in this research is CAPM (Capital Asset Pricing Model). The results of this study obtained that the announcement of the Economic Policy Package issued by the Government Jokowi - Jusuf Kalla does not affect the reaction of investors in the capital market, and it also applies to other variables.
Reaksi Investor Juventus terhadap Event Transfer Cristiano Ronaldo dan Matthijs De Ligt
Authors: Ismail Andy , Arianto Pipit
Published: July 2022

This research was conducted because in previous studies relating to player transfers and their effects on stock returns are still rarely examined, whereas in the ball industry many soccer clubs are listed. This research focuses on the transfer of Cristiano Ronaldo and Matthijs De Ligt conducted by Juventus Football Club and aims to examine the transfer event of Cristiano Ronaldo and Matthijs De Ligt conducted by Juventus Football Club influencing the reaction of Juventus investors viewed from abnormal returns. The time period used at the event starts from July to September 2018 at the transfer event of Cristiano Ronaldo and starts from July to September 2019 at the transfer event of Matthijs De Ligt. The abnormal return calculation method used in this study is the CAPM (Capital Asset Pricing Model). From the results of this study, it was found that the transfer event of Cristiano Ronaldo and Matthijs De Ligt conducted by Juventus Football Club did not affect investor reaction.
Pengaruh Harga, Iklan, dan Kualitas Produk terhadap Keputusan Pembelian Layanan Internet Telkomsel
Authors: Saputra Murjani , Putra Dwi Ardi Wicaksana
Published: July 2022

This study aims to determine the effect of price, advertising, and product quality on purchasing decisions. The sampling technique used is convenience sampling with a total of 70 respondents. This research instrument uses a questionnaire using a Likert scale to collect data on price, advertising, and product quality onpurchasing decisions. The results of this study indicate that the price partially does not have a significant effect on purchasing decisions. Then advertising partially has a significant positive influence on purchasing decisions. Product Quality partially does not have a significant effect on purchasing decisions. Simultaneously stated that the influence of price, advertising, and product quality together affect the decision to purchase Telkomsel internet services. The results contribute that the role of internet service advertising is indispensable in marketing internet products in rural areas.
Akurasi Model Trait Recognition (TR) sebagai Model Prediksi Kebangkrutan Bank di Indonesia
Authors: Zuliannisa Riskia
Published: July 2022

The banks that are often liquidated every year are the People's Credit Bank (BPR), while we rarely find commercial banks going bankrupt. In order for the company to continue operating, it is necessary for managers to always re-analyze, especially financial ratios. There are only 2 previous researchers who were correct and accurate in predicting bank bankruptcy. However, this research was conducted 17 years ago in connection with the 1998 monetary crisis and of course, the conditions are different now. This study uses the Trait Recognition (TR) model to determine the accuracy in predicting bankruptcy with a sample of 20 bankrupt banks and 20 non-bankrupt banks in the 2013-2017 period and using a purposive sampling method. The results show that the TR model has anaccuracy rate below the 80% standard accuracy. This study does not support previous research conducted because of the newness of the studied bank, a research phenomenon that is motivated by the economic conditions of each country, different study periods, as well as when the last study was conducted 17 years ago.
Analisis Pengaruh Penerapan Digital Marketing terhadap Penjualan Produk bagi Usaha Mikro dan Kecil dengan Pandemi Covid-19 sebagai Variabel Moderasi
Authors: Irwanto Rudi , Kristiyono Demitrius
Published: July 2022

The purpose of this study was to determine the effect of Digital Marketing, on Sales products and determine the effect of Digital Marketing with ease of Pandemic Covid-19 as a moderating variable on Sales Products in small and micro scale enterprises in Kota Besi with the ease of Pandemic Covid-19 as a moderating variable. As for what is presented as a population of enterprises in Kota Besi, the criteria of Micro and Small business of Kota Besi. The Sample taken in the study obtained 130 respondents, divided into 68 respondents who used Digital Marketing, and 62 respondents not use Digital Marketing. The sampling technique used is Convenience Sampling. The research instrument was in the form of a questionnaire using a Likert scale to collect data on variable Digital Marketing, covid-19 pandemic, and sales products, using the MRA (Moderating Regression Analysis). The results of this research indicate that Digital Marketing has a significant and positive effect on product sales. Another result of this research shows that the Covid-19 Pandemic is not a moderating variable in the relationship between Digital Marketing and Product Sales. The Covid-19 Pandemic is an independent variable (predictor) in relation to Product Sales.
Penyusunan Laporan Keuangan berdasarkan SAK EMKM (Studi Kasus pada UMKM Pangkalan LPG UD. Ahmad Baihaqi di Kuala Pembuang)
Authors: Wati Noor Sentya , Mulyanto Sigit
Published: July 2022

The purpose of this study was to determine the preparation of financial statements based on SAK EMKM at LPG Base UD. Ahmad Baihaqi provides benefits for preparing reports according to accounting standards, such as making it easier for MSME owners to make economic decisions. The descriptive-qualitative research method was used in this study. Sources of data are primary data and secondary data. The results of the research that has been carried out from January 1 to March 31, 2021, are in the form of a statement of financial position showing assets, liabilities, and equity of IDR 71,915,250, an income statement showing a profit of IDR 8,647,000 and notes on the LPG Base financial statements. UD. Ahmad Baihaqi.
Belanja Daerah Program Sektor Pertanian dan Dana Desa terhadap Angka Kemiskinan melalui PDRB Sektor Pertanian
Authors: Usaid Prasetyo Yuli , Yunani Ahmad
Published: July 2022

The rural poverty rate in South Kalimantan Province decreased in 2018 amidst the poverty rate between rural and urban areas is still relatively high. However, the high rate of urban population exceeding rural areas is followed by a higher poverty rate in rural areas than in cities. This research is a quantitative research using Partial Least Square (PLS) data analysis. This research was conducted in South Kalimantan Province. Election of South Kalimantan Province for the 2016-2017 period. The purpose of this study is to analyze how much influence the Agricultural Sector Regional Expenditures and Village Funds have on the agricultural sector GRDP, then the effect on its poverty rate. The results show that the Regional Expenditures for the Agricultural Sector Program and village funds do not significantly increase the GRDP of the Agricultural Sector. Regional Expenditures for the Agricultural Sector Program and village funds have a significant influence on the Poverty Rate. The GRDP of the Agricultural Sector has a significant influence on the Poverty Rate. Regional Expenditures for the Agricultural Sector Program through the GRDP of the Agricultural Sector and Village Funds do not have a significant effect on reducing the Poverty Rate inSouth Kalimantan.
Potensi Pohon Nipah dan Pemanfaatan terhadap Peningkatan Ekonomi Masyarakat Lokal
Authors: Hasaruddin Hasaruddin
Published: July 2022

Researchers conducted a study on Nipah Tree Potential and Utilization of Management to Improve the Economy of Local Communities. This study uses a qualitative approach, data analysis techniques that researchers use are in-depth interviews, observation, and documentation. The location of the research was carried out in the Tanjung Putri village community, South Arut sub-district, West Kotawaringin Regency. The research subjects were determined purposively, namely: (1) village heads and community groups who were business actors in the management of nipa palm trees; (2) community members. The following is a description of the research data, namely; Utilization that uses materials for building cottages for relaxing, as much as 58%. with direct sales, handicrafts in the form of baskets (Bakul), mats and hats as head protection, which utilizes Nipah shoots by 15%, then the community of stick broom craftsmen, which is as much as 35%. Meanwhile, for those who use as much as 40% of palm sugar, fruit that is made of fruit, and fro for additional iced cendol drinks, 45% of the Mayang Nipah portion is used as 5% consumption, development in terms of rejuvenation of nipa palm trees has not been maximized, also product development is very minimal due to lack of knowledge about the production of processed nipa palm fruit, this must then be a correction for policymakers to consider appropriate policy steps to improve economic conditions.
Keputusan Konsumen Menggunakan Ojek Sampit: Harga, Produk, Orang, dan Bukti Fisik
Authors: Restiyani Lina , Desliniati Nurfitri
Published: July 2022

The study was conducted to analyze the effect of price, promotion, people, and physical evidence on PitJek's purchasing decisions. There are five independent variables in the study, namely price, promotion, people, and physical evidence, and the dependent variable is purchasing decisions. Data were obtained by distributing questionnaires to 100 samples who had used the services of PitJek (Sampit Ojek). Samples were taken using the accidental sampling technique. The research analysis method is quantitative with validity and reliability tests, the analysis technique is the outer and inner models. The results of the analysis show that each statement is declared valid and reliable. In the results of hypothesis testing, it is found that price has a positive effect on purchasing decisions for PitJek services, while the results of promotions, people, physical evidence, and income (control variables) do not affect the purchasing decisions of PitJek services.
Elicitação de requisitos de Sistemas e Design Thinking no âmbito público: Um estudo de caso na Universidade Federal de Lavras
Authors: Macedo Letícia Gomes de , Oliveira Fernando Elias de , Araujo Renata Mendes de
Published: July 2022

Em um cenário de problemas complexos enfrentados pela Administração Pública, cresce a exigência por soluções mais eficazes. Entende-se que o Design Thinking tem um papel importante na elicitação de requisitos destas soluções. Esta pesquisa tem como objetivo mapear o processo vigente de elicitação de requisitos de sistemas em uma instituição pública, utilizando a UFLA enquanto estudo de caso, identificar com que frequência são utilizados elementos de Design Thinking no processo, e discutir oportunidades. Os resultados demonstram baixa frequência de utilização, havendo espaço para uma agenda de iniciativas que amplie a capacidade da Instituição de resolver problemas através de tecnologia.
Effects of Magnesium Oxide and Zinc Oxide Nanoparticles on Motor Activity, Electrocardiographic Parameters, and Oxidative Stress in an Acute Restraint Stress Model of Rats
Authors: Torabi Mozhgan , Kesmati Mahnaz , Najafzadeh Varzi Hossein , Pourreza Nahid
Published: July 2022

Background: Stress can alter behavioral parameters, oxidative stress markers, and electrocardiographic (ECG) records. Also, metal oxide nanoparticles can affect behavioral and oxidative stress parameters in animal models, but their effects on the physiological functions of the body in stress situations and ECG changes are not yet clear. Objectives: In this study, motor activity, ECG records, and oxidant/antioxidant balance changes were investigated following administration of nanoparticles of magnesium oxide (nano-MgO) and zinc oxide (nano-ZnO) in normal and acute restraint stressed rats. Methods: Adult male Wistar rats were divided into 16 groups, including control (saline), restraint stress (90, 180, and 360 minutes + saline), nano-MgO, and nano-ZnO (1, 5, and 10 mg/kg, intraperitoneally) groups, with or without restraint stress of 90 minutes. Motor activities were evaluated by the elevated plus maze (EPM) and open field tests. Electrocardiographic parameters were evaluated in the 6 groups. Catalase (CAT) activity and malondialdehyde (MDA) level were measured in the cerebellum + brain stem and brain hemispheres of animals. Results: Motor activity was decreased by the stress of 90 minutes, nano-MgO 10 mg/kg, and nano-ZnO 10 mg/kg. The PR interval and ST height were decreased by the stress of 90 minutes. The QRS interval was increased by nano-MgO 5 mg/kg, and QRS amplitude, T amplitude, and ST height were decreased by nano-MgO 5 mg/kg. The QT interval and QTc were increased by nano-ZnO 5 mg/kg, and ST height was decreased by nano-ZnO 5 mg/kg. The PR interval, QRS interval, QTc, and QT interval were increased by nano-MgO 5 mg/kg in the stress of 90 minutes, and the heart rate (HR) and ST height were decreased by nano-MgO 5 mg/kg in the stress of 90 minutes. HR, QRS interval, and QTc were increased by nano-ZnO 5 mg/kg in the stress of 90 minutes, and T amplitude and ST height were decreased by nano-ZnO 5 mg/kg in the stress of 90 minutes. The MDA level was increased by nano-MgO and nano-ZnO in the brain hemisphere and cerebellum + brain stem, and CAT activity was decreased by nano-MgO and nano-ZnO in the brain hemisphere and cerebellum + brain stem. The MDA level was increased by the restraint stress of 360 minutes in the cerebellum + brain stem while it was not changed in the brain hemispheres. Conclusions: It seems that the side effects of these nanoparticles on motor activity could be related to the imbalance of oxidant/antioxidant systems in the cerebellum + brain stem. Also, it is possible that nanoparticles increase the effects of acute stress on changes in ECG parameters.
Comparison of Effect of Aloe vera Gel and Nystatin on Candida Species: An In Vitro Study
Authors: Rezvaninejad Rayehehossadat , Rezvaninejad Raziyehsadat , Ashoorian Mohammad Javad , Talebi Maryam
Published: July 2022

Background: Oral candidiasis is an opportunistic fungal infection that leads to acute and chronic infections in the mouth and gastrointestinal tract. According to studies, common antifungal drugs have some side effects and sometimes fail in Candida albicans candidiasis infections. Objectives: This study aimed to compare the efficacy of Aloe vera to that of nystatin on oral Candida species in vitro. Methods: This laboratory study was prepared in vitro from a collection of fungi and bacteria in Iran. The measured inhibitory concentration was within the range of 1:1 to 1:2048. The data were analyzed using SPSS software (version 24). Results: In C. albicans species, the inhibitory concentration of Aloe vera gel was 312.5 μL/mL. The inhibitory concentrations for Candida glabrata and Candida tropicalis were 1250 and 625 μL/mL, respectively. In all groups, there was a significant relationship between Aloe vera and nystatin. Conclusions: Aloe vera gel showed antifungal properties in all tested species. The inhibitory concentrations of Aloe vera were much higher than nystatin. Therefore, to use this plant for humans, the concentration of its toxicity to humans should be estimated beforehand to avoid possible harm.
Relationship of Spiritual Well-being, Social Health, and Parent-Child Interaction with Health-Related Quality of Life in Parents of Children with Specific Learning Disorders
Authors: Mohammadchenari Behrooz , Marashian Fatemeh Sadat , Talebzadeh Shoushtari Marzieh
Published: July 2022

Background: Health encompasses physical, mental, emotional, intellectual, spiritual, and social dimensions. Parents' spiritual well-being can affect their social health and, therefore, their health-related quality of life (HRQOL). Objectives: In this study, we investigated the relationship between spiritual well-being, social health, parent-child interaction, and HRQOL in parents of children with specific learning disorders. Methods: This study investigated the relationship between spiritual well-being, social health, and the statistical population in this descriptive-correlational study comprised all parents of children with certain learning disorders in Andimeshk, Iran, in 2020. Through convenience sampling, 174 parents were selected as the sample. The study used instruments, including the Health-related Quality of Life Questionnaire, the Spiritual Well-being Questionnaire, Keyes's Social Wellbeing Questionnaire (KSWBQ), and the Pianta Child-Parent Relationship Scale (CPRS). Statistical analysis of the data was conducted using Pearson correlation coefficients and simultaneous regression models. Results: There was a significant positive relationship between HRQOL and spiritual well-being, social health, and parent-child interaction (P < 0.001). In addition, the regression analysis demonstrated multiple correlations between HRQOL and spiritual well-being, social health, and parent-child interaction (R = 0.48, P < 0.001). Conclusions: The study found that spiritual well-being, social health, and parent-child interactions were essential in the HRQOL of parents of children with specific learning disabilities.
Impact of COVID-19 in Chronic Viral Hepatitis B Patients on Virological, Clinical, and Paraclinical Aspects
Authors: Naderi Malihe , Hosseini Seyed Masoud , Behnampour Naser , Shahramian Iraj , Moradi Abdolvahab
Published: July 2022

Background: Coronavirus disease 2019 (COVID-19) is caused by an infection in the respiratory tract leading to extrapulmonary manifestations, including dysregulation of the immune system and hepatic injury. Objectives: Given the high prevalence of viral hepatitis and a few studies carried out on severe acute respiratory syndrome coronavirus 2 and hepatitis B virus (HBV), this study investigated the impact of COVID-19 on chronic hepatitis B (CHB) patients in the northeast region of Iran. Methods: In this cross-sectional study, the blood samples were collected from 93 CHB patients registered in the Patient Detection Data Bank of Golestan University of Medical Sciences, Gorgan, Iran, and 62 healthy individuals as controls. Reverse transcription-polymerase chain reaction was adopted to detect COVID-19 infection in all the participants’ nasopharyngeal samples. All the participants were subjected to anti-hepatitis C virus, anti-hepatitis delta virus, and liver function tests. Then, HBV deoxyribonucleic acid load was detected in CHB patients. The collected data were analyzed by statistical tests using SPSS software (version 20). A P-value less than 0.05 was considered statistically significant. Results: In this study, 14% (13/93) and 32.25% (20/62) of CHB patients and control individuals were infected with COVID-19, respectively. The mean age of CHB patients was 39.69 ± 19.58 years, and 71% of them were female. The risk of developing COVID-19 in healthy controls was observed to be 2.3 times higher than in patients with CHB (0.95% confidence interval: 1.242 - 4.290). On the other hand, the mean values of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase in CHB patients superinfected with COVID-19 were higher than other participants. Out of 35.4% of patients with viral hepatitis B that were taking antiviral drugs, only 5.4% had COVID-19. Conclusions: Although CHB infection did not predispose COVID-19 patients to more severe outcomes, the data of this study suggest that antiviral agents also decreased susceptibility to COVID-19 infection. Alternatively, careful assessment of hepatic manifestations and chronic viral hepatitis infections in COVID-19 patients can lead to more favorable health outcomes.
Adalimumab Efficacy for Management of Inflammatory Bowel Disease in Southwest Region of Iran
Authors: Alavinejad Pezhman , Delavari Sana , Parsi Abazar , Shayesteh Ali Akbar
Published: July 2022

Background: In recent years, biological drugs, including antitumor necrosis factors, have revolutionized the treatment of inflammatory bowel disease (IBD); however, there is no consensus about the superiority of adalimumab over infliximab. Objectives: This study was designed to evaluate the efficacy of adalimumab for the management of IBD in the southwest region of Iran. Methods: During this prospective observational study, the patients with active IBD and a history of no response to previous treatments that referred to an IBD clinic were included. Moreover, this study evaluated and compared the effectiveness of treatment, including clinical remission rate, disease activity index (the Mayo score in ulcerative colitis (UC) patients and the Crohn’s disease activity index (CDAI) in Crohn’s disease (CD) patients), clinical response, and side effects related to adalimumab injection in 0, 12th, 24th, and 52nd weeks after treatment. Results: A total of 71 patients, including 42 male and 29 female, with a mean age of 29 years, were included. In this study, 37 and 34 patients were diagnosed with UC (52.1%, 20 male and 17 female) and CD (47.8%, 22 male and 12 female), respectively. The time to remission in the UC group was significantly longer than in the CD group (10.05 and 1.71 months; P < 0.0001). Clinical remission rate (≥ 2 points reduction in the Mayo score) in the 12th week among UC patients after treatment with adalimumab was 67.5% and raised to 100% (all the UC patients) in the 24th and 52nd weeks after treatment. None of the UC patients experienced disease recurrence. In CD patients, the CDAI significantly decreased during the treatment time (P < 0.0001); however, all CD patients (100%) experienced disease recurrence after a mean time of 2.59 ± 0.55 months (within 2 - 4 months) (P < 0.0001). Failure of treatment was observed in 94.1% of CD patients (n = 32); nevertheless, none of the UC patients had treatment failure (P < 0.0001). There were no complications related to adalimumab, and no patients needed colectomy during the study period. Conclusions: Adalimumab has a positive effect on the improvement of clinical symptoms, reduction of disease activity, prevention of disease recurrence, and need for colectomy in moderate to severe UC patients. However, adalimumab has no efficacy in the improvement of CD patients, and failure of treatment was observed in most of these patients. Adalimumab could be a therapeutic option for the management of UC with prior failure of treatment.
Number of stable digits of any integer tetration
Authors:   sPIqr Society, World Intelligence Network, Ripà Marco , Onnis Luca
Published: July 2022

In the present paper we provide a formula that allows to compute the number of stable digits of any integer tetration base a \in {\mathbb N}_0. The number of stable digits, at the given height of the power tower, indicates how many of the last digits of the (generic) tetration are frozen. Our formula is exact for every tetration base which is not coprime to 10, although a maximum gap equal to V(a)+1 digits (where V(a) denotes the constant congruence speed of a) can occur, in the worst-case scenario, between the upper and lower bound. In addition, for every a>1 which is not a multiple of 10, we show that V(a) corresponds to the 2-adic or 5-adic valuation of a-1 or a+1, or even to the 5-adic order of a^2+1, depending on the congruence class of a modulo 20.
Developing evolution-resistant drugs for COVID-19
Authors: Weinreich Daniel M
Published: July 2022

Analyzing how mutations affect the main protease of SARS-CoV-2 may help researchers develop drugs that are effective against current and future variants of the virus.
PDCA Cycle in Quality Processes: Proficiency Levels of Turkish Universities According to the Opinions of External Evaluators
Authors: YAZICI Sedat , ÜNAL Fatma , ÇULHAOĞLU Özer
Published: July 2022

Türk üniversiteleri kalite ve akreditasyon süreçlerinde hızlı bir değişim, dönüşüm yaşamaktadır. Sürecin paydaşları birçok yeni kavram, yöntem ve teknikle karşılaşmaktadır. Planla, Uygula, Kontrol Et, Önlem Al (PUKÖ) döngüsü Türkiye’de yükseköğretim kalite süreçlerinde kullanılması sıklıkla önerilen bir tekniktir. Çalışmanın amacı, PUKÖ döngüsünün kavramsal ve kuramsal çerçevesini tanıtmak; kalite süreçlerine katılan değerlendiricilerin görüşlerine göre Türkiye’de yükseköğretim kurumlarında PUKÖ döngüsünün uygulanma durumunu incelemek; döngünün yükseköğretimde uygulama alanlarını tespit etmektir. Çalışmada, nitel araştırma desenlerinden durum çalışması kullanılmıştır. Yükseköğretim kalite süreçlerinde dış değerlendirici olarak görev alan 42 katılımcıdan elde edilen veriler analiz edilmiş, üniversitelerde bilgi yetersizliklerinin olduğu; döngüyü bir zorunluluk gereği kullandıkları, Planla ve Uygula aşamalarının başarıyla gerçekleştirildiği ancak Kontrol Et ve Önlem Al aşamalarının yetersiz düzeyde gerçekleştirildiği görülmüştür. Bazı katılımcıların izleme sürecinde veri toplama sorununa işaret etmelerine rağmen genel olarak PUKÖ döngüsünün kullanımında yararlanabilecek araçlara dikkat çekmemiş olmaları, döngüyü kendi başına yeterli bir iyileştirme aygıtı olarak algılıyor olmaları şaşırtıcıdır. Sonuçlar, PUKÖ döngüsünün teknik açıdan kullanma yeterliliği konusunda önemli eksikliklerin olduğunu göstermektedir. Katılımcılar, döngünün kullanımıyla ilgili eğitim gereksinimini belirtmekle birlikte hangi araçlarla desteklenmesi gerektiği, ne gibi yöntemsel veya teknik eksikliklerin olduğu konusunda herhangi bir görüş bildirmemişlerdir. YÖKAK ve üniversitelerin PUKÖ uygulamasında kullanılan yardımcı araçlarla ilgili eğitim desteği sağlaması, döngünün etkin şekilde kullanılmasına katkı sağlayacaktır.
Tuning of Thermometric Performances of Mixed Eu–Tb Metal–Organic Frameworks through Single‐Crystal Coordinating Solvent Exchange Reactions
Authors: Kourtellaris Andreas , Lafargue‐Dit‐Hauret William , Massuyeau Florian , Latouche Camille , Tasiopoulos Anastasios J. , Serier‐Brault Hélène
Published: July 2022

An initial investigation on the employment of targeted structural alterations, achieved through the post‐synthesis modification method, for modulation of the thermometric properties of metal–organic frameworks (MOFs) is reported. The MOF Eu0.05Tb0.95‐NBDC (NBDC = 2‐amino‐1,4‐benzenedicarboxylate) is chosen as pristine material, and its terminal N,N‐dimethylformamide (DMF) molecules are exchanged by various terminal and chelating ligands through a single‐crystal‐to‐single‐crystal coordinating solvent exchange reaction. Temperature‐dependence luminescence studies reveal that all samples are highly sensitive in the medium range with a maximum relative sensitivity of 2.6% K−1 at 190 K for Eu0.05Tb0.95‐NBDC. In addition, a shift of 50 K of the operating temperature range is evidenced for the exchanged analogs. This is attributed to the occurrence of different deactivation pathways in the exchanged analogs due to the presence of N‐donor terminal or N/O‐donor chelating aromatic ancillary ligands in the place of DMF terminal ligands in the pristine material. Overall, this work provides insights into the role of terminal and chelating ligands on the thermometric properties of mixed Eu–Tb MOFs and proposes a promising strategy to control and modulate their thermometric performances.
Water‐Facilitated Nitromethane‐Mediated Cyclization of 2‐(Phenylvinyl)benzhydrols: Access to 1,3‐Diphenyl‐1H‐indenes with Antitumor Activity
Authors: Hauguel Camille , Tran Christine , Provot Olivier , Bignon Jérôme , Gandon Vincent , Hamze Abdallah
Published: July 2022

This work reports a mild and operationally accessible method for synthesizing 1,3‐diphenyl‐1H‐indene derivatives from N‐tosylhydrazones and bromobenzhydrols as readily available reactants. Moreover, the cyclization step does not require metal catalysis, the addition of an acid, or a very high temperature. We report a combined experimental and computational study on the mechanism of this cyclization. In addition, we demonstrate the utility of this methodology by synthesizing a large number of products, even on the gram‐scale, and by the obtention of new biologically relevant molecules.

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Realistic and inexpensive ultrasound phantoms to demonstrate aortic aneurysm and aortic dissection
Authors: Rathbun Kimberly M. , Harryman Claire F. , Moore Corey
Published: July 2022

Introduction

Using ultrasound to evaluate for the presence of aortic pathology is a common procedure in the emergency department. Phantoms are models that are used to simulate clinical conditions for teaching ultrasound‐related skills. To date, no ‘homemade’ phantom has been created to model aortic aneurysms, and no phantoms exist to model aortic dissection.

Methods

We used several readily available, inexpensive ingredients to create ultrasound phantoms.

Results

These phantoms realistically mimic aortic aneurysm and aortic dissection.

Discussion

These are the first ‘homemade’ phantoms that demonstrate aortic pathology.

Conclusions

We have created realistic, affordable, easily reproducible phantoms for use in teaching clinicians to use ultrasound when evaluating patients for aortic aneurysm and/or aortic dissection.
A 4‐Arm Small Molecule Acceptor with High Photovoltaic Performance
Authors: Meng Xianyi , Li Mingjie , Jin Ke , Zhang Lixiu , Sun Jie , Zhang Wenhua , Yi Chenyi , Yang Junliang , Hao Feng , Wang Guan‐Wu , Xiao Zuo , Ding Liming
Published: July 2022

Manipulating the backbone of small molecule acceptors (SMAs) is of particular importance in developing efficient organic solar cells (OSCs). The common design is constructing 2‐arm SMAs with linear or curved backbones. Herein, we report an acceptor 4A‐DFIC with a 4‐arm backbone unexpectedly generated in the reaction of an electron‐rich aromatic diamine and hexaketocyclohexane. Single‐crystal X‐ray diffraction analysis indicates the rigid and twisted molecular plane and the effective molecular stacking of 4A‐DFIC in solid state. 4A‐DFIC shows a low band gap of 1.40 eV and excellent light‐harvesting capability from visible to near‐infrared region. Binary and ternary OSCs based on 4A‐DFIC gave power conversion efficiencies (PCEs) of 15.76 % and 18.60 % (certified 18.1 %), respectively, which are the highest PCEs for multi‐arm SMA‐based OSCs to date.
Synthesis, Characterization and Reactivity of a σ‐Donating Ni0‐Stabilized Silyliumylidene Ion
Authors: Takahashi Shintaro , Frutos María , Baceiredo Antoine , Madec David , Saffon‐Merceron Nathalie , Branchadell Vicenç , Kato Tsuyoshi
Published: July 2022

The synthesis of a silyliumylidene cation complex2stabilized by a Ni0‐based donating ligand is reported. Experimental and theoretical studies demonstrate that the highly electrophilic SiIIcenter is stabilized by a dative Ni→Si σ‐interaction and π‐donations from the amino‐ and Ni‐moieties. Due to the energetically close frontier orbitals localized on the Si and Ni atoms, complex2presents a competitive reactivity at Si and Ni sites.
Desymmetric Cyanosilylation of Acyclic 1,3‐Diketones
Authors: Xu Pan , Shen Chang , Xu Aiqing , Low Kam‐Hung , Huang Zhongxing
Published: July 2022

Diastereo‐ and enantioselective construction of vicinal stereocenters from easily available starting materials is a challenging task. Here, we report that a bifunctional catalyst prepared from dibutylmagnesium and a pipecolinol‐derived tetradentate ligand can enable an asymmetric cyanosilylation of 1,3‐diketones to forge a pair of neighboring and acyclic tetrasubstituted carbons. The high stereoselectivity results from the rigid conformation of the diketone in the catalyst pocket, where the Lewis acidic magnesium center, together with the free hydroxyl group as a putative hydrogen bond donor, bind with both carbonyls. Consequently, stereochemically well‐defined cyanohydrin silyl ethers with a diverse collection of substituents were prepared. Their rapid derivatization to molecules of higher complexity, such as heterocycles, triols, and fused rings, were also demonstrated.
Selenoviologen‐Appendant Metallacycles with Highly Stable Radical Cations and Long‐Lived Charge Separation States for Electrochromism and Photocatalysis
Authors: Zhang Sikun , Ma Lingzhi , Ma Wenqiang , Chen Long , Gao Kai , Yu Shi , Zhang Mingming , Zhang Lei , He Gang
Published: July 2022

Two coordinated metallacycles (rhomboid forM1, hexagonal forM2) with selenoviologens (SeV2+) pendants were synthesized via coordination‐driven hierarchical self‐assembly.M1/M2with rigid and discrete metallacyclic cores showed tunable optoelectronic properties due to strong π–π stacking and push–pull electron structures. Femtosecond transient absorption (fs‐TA) revealed that the formation of macrocyclic structure can not only enhance the stability of radical cation, but also improve the efficiency of intramolecular charge transfer and produce a long‐lived charge separation state. The electrochromic performances ofM1/M2‐based devices were exhibited to show decent radical stabilization. By usingM1/M2as the photocatalyst, the improved catalytic efficiency (>80 %) of visible‐light‐induced cross‐dehydrogenative coupling (CDC) reactions was achieved due to the highly stable radical cations and long‐lived charge separation states, which were also confirmed by fs‐TA.
Synthesis of α‐Aryl Acrylamides via Lewis‐Base‐Mediated Aryl/Hydrogen Exchange
Authors: Lemmerer Miran , Zhang Haoqi , Fernandes Anthony J. , Fischer Tobias , Mießkes Marianne , Xiao Yi , Maulide Nuno
Published: July 2022

Herein we report a method for the synthesis of α‐aryl acrylamides leveraging polar S‐to‐C aryl migrations induced by a Lewis basic organocatalyst. In contrast to previously reported radical aryl migrations of sulfonyl acrylimides, this polar process enables subsequent elimination, ultimately leading to a formal aryl/hydrogen exchange including SO2 extrusion. This reaction is selective for electron‐deficient aromatic groups, while tolerating a variety of substituents on nitrogen and in the β‐position, and it delivers useful building blocks for further transformations, including cycloaddition and cyclisation reactions. The mechanism was investigated in detail using quantum chemical calculations, which unexpectedly revealed the Lewis base to be involved in several decisive steps.
Biomimetic Total Synthesis and Investigation of the Non‐Enzymatic Chemistry of Oxazinin A
Authors: Aniebok Victor , Shingare Rahul D. , Wei‐Lee Hsiau , Johnstone Timothy C. , MacMillan John B.
Published: July 2022

We report the first total synthesis of an antimycobacterial natural product oxazinin A that takes advantage of a multi‐component cascade reaction of anthranilic acid and a precursor polyketide containing an aldehyde. The route utilized for the synthesis of the pseudodimeric oxazinin A validates a previously proposed biosynthetic mechanism, invoking a non‐enzymatic pathway to the complex molecule. We found a 76 : 10 : 9 : 5 ratio of oxazinin diastereomers from the synthetic cascade, which is an identical match to that found in the fermentation media from the fungus Eurotiomycetes 110162. Further investigation of the non‐enzymatic formation of oxazinin A using 1H‐15N HMBC NMR spectroscopy allowed for a plausible determination of the stepwise mechanism. The developed route is highly amenable for the synthesis of diverse sets of analogs around the oxazinin scaffold to study structure–activity relationships (SAR).