bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacterial Isolates Derived from Nest Soil Affect the Attraction and Digging Behavior of Workers of the Red Imported Fire Ant, Solenopsis invicta Buren
Authors: Travanty Nicholas , Vargo Edward , Schal Coby , Apperson Charles , Ponnusamy Loganathan
Published: May 2022

Populations of monogyne and polygyne red imported fire ants (RIFA), Solenopsis invicta Buren, are distributed throughout the southern United States. This ant species is hazardous to farm animals and workers, damages infrastructure, and depletes native arthropod populations. Colony expansion is affected by several biotic factors, but the effects of soil microbes on ant behavior related to soil excavation within nest sites have not been investigated. Consequently, we cultured bacteria from RIFA nest soils. The effects of individual bacterial isolates and bacterial cell densities on the choice of digging site as well as digging activity of monogyne and polygyne RIFA worker ants were evaluated in two-choice bioassays. Based on phylogenetic analysis, 17 isolates were selected and tested initially at 5 × 108 cells/mL and 20 workers per assay. Firmicutes (Bacillus, Paenibacillus, Brevibacillus) repelled the ants, but Arthrobacter woluwensis strongly attracted ants. Subsequently, the six isolates having the greatest positive or negative effects on ant behavior were evaluated at a lower bacterial cell and worker ant densities. Ant responses to these bacteria generally decreased as cell densities declined to 5 × 106 cells/mL. Observations of ant behavior during a three-hour, two-choice bioassay revealed that ants generally visited both control and bacteria-treated sand prior to making a digging site choice. Our research results indicate that soil bacteria may mediate ant nest expansion or relocation and foraging tunnel construction. Identification of bacterial metabolites that affect RIFA digging behavior merits additional research because these compounds may provide a basis for novel management strategies that repel RIFA away from sensitive infrastructure or attract fire ants to insecticidal baits.
Installation Season May Significantly Impact Time Required for Subterranean Termites to Find and Feed on In-Ground Baits
Authors: Sutherland Andrew M. , Hubble Casey , Barber Molly
Published: May 2022

Rhinotermitid termites, serious pests of wooden structures throughout the world, are commonly controlled with chitin synthesis inhibitor bait systems. Seasonal termite foraging patterns in some regions may prolong bait interception time, however, significantly decreasing colony elimination speed. We hypothesized that installing baits immediately prior to the season of highest foraging activity will minimize interception time when baiting for Reticulitermes spp. in California, a region characterized by a hot-summer Mediterranean climate. To test this theory, we installed three different bait systems on four dates corresponding to the major seasons (spring, summer, autumn, winter) at five field locations known to harbor the target species. We then recorded initial termite discovery events every 60 days for two years, considering effects of installation season, bait system, site, and distance from previously observed termite incidence on bait interception time. Observed foraging activity in bait stations was highest during late winter and spring. Baits installed during winter exhibited interception times more than 100 days shorter than those of baits installed during summer. From these findings, we conclude that colony elimination speed and perceived CSI bait utility may be increased in Mediterranean climate regions when baits are installed immediately prior to the wet season.
Edible Insect Farming in the Context of the EU Regulations and Marketing—An Overview
Authors: Żuk-Gołaszewska Krystyna , Gałęcki Remigiusz , Obremski Kazimierz , Smetana Sergiy , Figiel Szczepan , Gołaszewski Janusz
Published: May 2022

Insects are increasingly being considered as an attractive source of protein that can cater to the growing demand for food around the world and promote the development of sustainable food systems. Commercial insect farms have been established in various countries, mainly in Asia, but in Europe, edible insects have not yet emerged as a viable alternative to traditional plant- and animal-based sources of protein. In this paper, we present an interdisciplinary overview of the technological aspects of edible insect farming in the context of the EU regulations and marketing. Based on a review of the literature, we have concluded that edible insect farming can be a viable business sector that significantly contributes to the overall sustainability of food systems if the appropriate regulations are introduced and food safety standards are guaranteed. However, the success of the edible insect industry also requires consumer acceptance of entomophagy, which is rather low in Western societies. Therefore, targeted marketing strategies are indispensable to support the implementation of edible insect programs.
Wing Planform Effect on the Aerodynamics of Insect Wings
Authors: Li Hao , Nabawy Mostafa
Published: May 2022

This study investigates the effect of wing planform shape on the aerodynamic performance of insect wings by numerically solving the incompressible Navier-Stokes equations. We define the wing planforms using a beta-function distribution and employ kinematics representative of normal hovering flight. In particular, we use three primary parameters to describe the planform geometry: aspect ratio, radial centroid location, and wing root offset. The force coefficients, flow structures, and aerodynamic efficiency for different wing planforms at a Reynolds number of 100 are evaluated. It is found that the wing with the lowest aspect ratio of 1.5 results in the highest peaks of lift and drag coefficients during stroke reversals, whereas the higher aspect ratio wings produce higher lift and drag coefficients during mid half-stroke translation. For the wings considered, the leading-edge vortex detachment is found to be approximately at a location that is 3.5–5 mean chord lengths from the wing center of rotation for all aspect ratios and root offsets investigated. Consequently, the detachment area increases with the increase of aspect ratio and root offset, resulting in reduced aerodynamic coefficients. The radial centroid location is found to influence the local flow evolution time, and this results in earlier formation/detachment of the leading-edge vortex for wings with a smaller radial centroid location. Overall, the best performance, when considering both average lift coefficient and efficiency, is found at the intermediate aspect ratios of 4.5–6; increasing the centroid location mainly increases efficiency; and increasing the root offset leads to a decreased average lift coefficient whilst leading to relatively small variations in aerodynamic efficiency for most aspect ratios.
Donor-Recipient Weight Match in Pediatric Heart Transplantation: Liberalizing Weight Matching with Caution
Authors: Chen Ming , Xu Li , Yu Wenjing , Qian Xingyu , Rao Zhenqi , Tu Jingrong , Dong Nianguo , Li Fei
Published: May 2022

(1) Background: To expand the donor pool, greater donor hearts tended to be used in heart transplantation. However, the data about the feasibility of expanding the donor and recipient weight ratios (DRWRs. All donor and recipient weight ratio (DRWR) in this study or cited from other articles were converted to the DRWR calculated by ((donor weight-recipient weight)/recipient weight) × 100%.) to >30% was still scant in China’s pediatric heart transplantation (HTx). The potential risk increased along with the further expansion of the appropriate range of DRWR to >30% and its upper limit was still in debate. (2) Methods: Seventy-eight pediatric patients (age < 18 years) undergoing HTx between 2015 and 2020 at our center were divided into two groups based on the DRWR (>30% and ≤30%). Variables were summarized and analyzed via univariate analyses and multivariate analyses. A Kaplan-Meier methodology was used to calculate survival and conditional survival. (3) Results: No significant difference was found in one-year, three-year or five-year survival between the two groups. (4) Conclusions: The expansion of DRWR to >30% was acceptable for China’s pediatric HTx. Notably, continuously liberalizing of the upper DRWR boundary to more than 200% could be used as a stop-loss option but should be applied with caution.
Effect of Vitamin D Supplementation on the Cerebral Placental Ratio in Pregnancy Complicated with Early Fetal Growth Restriction
Authors: Jakubiec-Wisniewska Karolina , Huras Hubert , Kolak Magdalena
Published: May 2022

Fetal growth restriction (FGR) is a complication of pregnancy connected with increased risk of intrauterine fetal demise. To increase the diagnostic accuracy, the cerebral placental ratio (CPR) is used. Vitamin D may play a role in the regulation of vascular flow in the fetus. The aim is to assess the relationship between CPR and vitamin D supplementation in fetuses with early FGR. It is a prospective cohort study. Pregnant females were divided into groups with 2000 IU and <500 IU of vitamin D. Both groups were observed for 14 days; USG was performed three times with one-week intervals. EFW and CPR were measured. Absolute CPR values were initially observed to differ significantly (p = 0.0032). Measurements on the seventh day of observation indicated that CPR was significantly higher (p = 0.0455) in fetuses of patients receiving vitamin D at a dose of 2000 IU 1.75 (IQR: 1.47; 2.06) vs. <500 IU group 1.55 (IQR: 1.04; 1.52). Similarly, on day 14: (p < 0.0001)—2.39 (IQR: 1.82; 2.69) vs. 1.21 (IQR: 0.98; 1.52). Supplementation with vitamin D at a dose of 2000 IU may have an influence on the increase in the CPR in fetuses with early FGR.
Peri-Implant Distal Radius Fracture: Proposal of a New Classification
Authors: Stramazzo Leonardo , Rovere Giuseppe , Cioffi Alessio , Vigni Giulio Edoardo , Galvano Nicolò , D’Arienzo Antonio , Letizia Mauro Giulia , Camarda Lawrence , D’Arienzo Michele
Published: May 2022

A peri-implant fracture near the volar plate of the distal radius represents a rarity and can be associated with a mechanical failure of the devices. A literature review was conducted including all fractures that occurred around a volar wrist plate, which could be associated with an ulna fracture. All articles published until December 2021 were considered according to the guidelines presented in the PRISMA Statement. The search was conducted with the PubMed electronic database, Cochrane Database of Systematic Reviews, Medline, Embase, and Google Scholar. Only nine cases of these fractures were reported in the literature. The causes could be due to delayed union/non-union of the old fracture after low energy traumas, high energy trauma in patients with poor bone quality, or hardware mechanical failure. Furthermore, the literature review of peri-implant radius fracture shows different level of radius fracture and types of implant failure. In accordance with these different cases, a new classification of peri-implant fracture of the distal radius is proposed.
Terrorism’s Impact on Mental Health Outcomes among Directly and Indirectly Exposed Victims and the Development of Psychopathology
Authors: Mazurkiewicz Dariusz , Strzelecka Jolanta , Piechocka Dorota
Published: May 2022

After the events of 9/11, many police-responders developed post-traumatic stress disorder (PTSD) and were potentially vulnerable to developing depression and/or anxiety; in addition, nearly half of police with probable PTSD had comorbid depression and anxiety. Having in mind that victims who experience the effects of terrorism are exposed to high levels of psychological damage, we thus aimed to determine how sequelae of a terrorist act directly and indirectly affect victims. Quantitative synthesis findings were concluded on the basis of 200 records that met the inclusion criteria out of a total of 650. We grouped the patients according to their level of exposure to the WTC terrorist attack on 11 September 2001. The Level I group included individuals who had experienced the traumatic event and/or those who had observed the attack. The Level II group consisted of rescuers and/or persons who cleaned up debris in the area after the attack. The Level III group comprised the victims’ families. Our research enabled us to create a profile for those who were most vulnerable to mental disorders after the WTC terrorist attack. Patients who had survived the terrorist attack and/or those who had observed the incident exhibited fewer traumatic symptoms and a lower percentage of suicidal thoughts in comparison to individuals who had worked as rescuers or cleaning staff in the area after the attack. The number of symptoms rose along with increased contact time with the stressor. The dominant symptom was the triad of intrusion, avoidance, and hyperarousal. The findings may confirm the positive effect of protracted court cases in legal proceedings for compensation on the maintenance and development of psychopathology. Our research may contribute to a better understanding of the consequences of terrorism outcomes on the human psyche and be used in the development of standards for dealing with victims of terrorism’s impact.
Efficacy of Tildrakizumab for the Treatment of Difficult-to-Treat Areas: Scalp, Nail, Palmoplantar and Genital Psoriasis
Authors: Galluzzo Marco , Talamonti Marina , Cioni Arnaldo , Maffei Virginia , Shumak Ruslana Gaeta , Tofani Lorenzo , Bianchi Luca , Campione Elena
Published: May 2022

Tildrakizumab, an IL-23 inhibitor, is effective and safe for the improvement of moderate-to-severe chronic plaque psoriasis. However, little evidence is available on the use of this biologic in psoriasis in difficult-to-treat locations. In this retrospective analysis, we treated patients with 100 mg tildrakizumab at Day 0, after 4 weeks and every 12 weeks thereafter. Disease severity and treatment response was assessed by the Psoriasis Area and Severity Index (PASI), the static Physician’s Global Assessment of Genitalia (sPGA-G), the Psoriasis Scalp Severity Index (PSSI), Nail Psoriasis Severity Index (NAPSI) and the Palmoplantar Psoriasis Area and Severity Index (ppPASI) at baseline and after 4, 12 and 28 weeks. We followed 18 patients (mean age 49.1 ± 12.7 years, 61.1% male) with psoriasis localized to the genital region (N = 7), scalp (N = 6), nails (N = 5) and palmar/plantar areas (N = 7). PASI score decreased from 11.5 at baseline to 3.1 and 2.4 at 12 and 28 weeks. Tildrakizumab treatment decreased sPGA-G (3.3 to 0.2), PSSI (36.2 to 2.7), NAPSI (48.4 to 15.7) and ppPASI (5.3 to 0) from baseline to 28 weeks, respectively. Data from this real-life retrospective analysis shows that tildrakizumab is an effective option for the management of psoriasis in difficult-to-treat areas.
Hereditary Hemorrhagic Telangiectasia and Arterio-Venous Malformations—From Diagnosis to Therapeutic Challenges
Authors: Floria Mariana , Năfureanu Elena Diana , Iov Diana-Elena , Sîrbu Oana , Dranga Mihaela , Ouatu Anca , Tănase Daniela Maria , Bărboi Oana Bogdana , Drug Vasile Liviu , Cobzeanu Mihail Dan
Published: May 2022

Hereditary hemorrhagic telangiectasia is a rare autosomal dominant vascular disease defined by the presence of mucosal and cutaneous telangiectasia and visceral arterio-venous malformations. The latter are abnormal capillary-free direct communications between the pulmonary and systemic circulations with the following consequences: arterial hypoxemia caused by right-to-left shunts; paradoxical embolism with transient ischemic attack or stroke and brain abscess caused by the absence of the normally filtering capillary bed; and hemoptysis or hemothorax due to the rupture of the thin-walled arterio-venous malformations (particularly during pregnancy). It is frequently underdiagnosed, commonly presenting as complications from shunting through arterio-venous malformations: dyspnea, chronic bleeding, or embolism. Arterio-venous malformations are present not only in the lungs, but can also be found in the liver, central nervous system (mainly in the brain), nasal mucosa, or the gastrointestinal tract. The first choice of therapy is embolization of the afferent arteries of the arterio-venous malformations, a minimally invasive procedure with a high efficacy, a low morbidity, and low mortality. Other therapeutic modalities are surgery (resection) or stereotactic radiosurgery (using radiation). Routine screening for arterio-venous malformations is indicated in patients diagnosed with this condition and can prevent severe complications such as acute hemorrhages, brain abscesses, or strokes. Clinicians should provide a long-term follow-up for patients with arterio-venous malformations, in an effort to detect their growth or reperfusion in case of previously treated malformations. In spite of two experts’ consensuses, it still possesses multiple therapeutic challenges for physicians, as several aspects regarding the screening and management of arterio-venous malformations still remain controversial. Multidisciplinary teams are especially useful in complex cases.
Outcome Analysis in Elective Electrical Cardioversion of Atrial Fibrillation Patients: Development and Validation of a Machine Learning Prognostic Model
Authors: Nuñez-Garcia Jean C. , Sánchez-Puente Antonio , Sampedro-Gómez Jesús , Vicente-Palacios Victor , Jiménez-Navarro Manuel , Oterino-Manzanas Armando , Jiménez-Candil Javier , Dorado-Diaz P. Ignacio , Sánchez Pedro L.
Published: May 2022

Background: The integrated approach to electrical cardioversion (EC) in atrial fibrillation (AF) is complex; candidates can resolve spontaneously while waiting for EC, and post-cardioversion recurrence is high. Thus, it is especially interesting to avoid the programming of EC in patients who would restore sinus rhythm (SR) spontaneously or present early recurrence. We have analyzed the whole elective EC of the AF process using machine-learning (ML) in order to enable a more realistic and detailed simulation of the patient flow for decision making purposes. Methods: The dataset consisted of electronic health records (EHRs) from 429 consecutive AF patients referred for EC. For analysis of the patient outcome, we considered five pathways according to restoring and maintaining SR: (i) spontaneous SR restoration, (ii) pharmacologic-cardioversion, (iii) direct-current cardioversion, (iv) 6-month AF recurrence, and (v) 6-month rhythm control. We applied ML classifiers for predicting outcomes at each pathway and compared them with the CHA2DS2-VASc and HATCH scores. Results: With the exception of pathway (iii), all ML models achieved improvements in comparison with CHA2DS2-VASc or HATCH scores (p < 0.01). Compared to the most competitive score, the area under the ROC curve (AUC-ROC) was: 0.80 vs. 0.66 for predicting (i); 0.71 vs. 0.55 for (ii); 0.64 vs. 0.52 for (iv); and 0.66 vs. 0.51 for (v). For a threshold considered optimal, the empirical net reclassification index was: +7.8%, +47.2%, +28.2%, and +34.3% in favor of our ML models for predicting outcomes for pathways (i), (ii), (iv), and (v), respectively. As an example tool of generalizability of ML models, we deployed our algorithms in an open-source calculator, where the model would personalize predictions. Conclusions: An ML model improves the accuracy of restoring and maintaining SR predictions over current discriminators. The proposed approach enables a detailed simulation of the patient flow through personalized predictions.
The Cognitive Sequelae of Transient Ischemic Attacks—Recent Insights and Future Directions
Authors: Ganesh Aravind , Barber Philip A.
Published: May 2022

There is now considerable evidence that Transient Ischemic Attack (TIA) carries important sequelae beyond the risk of recurrent stroke, particularly with respect to peri-event and post-event cognitive dysfunction and subsequent cognitive decline. The occurrence of a TIA could provide an important window in understanding the relationship of early mixed vascular-neurodegenerative cognitive decline, and by virtue of their clinical relevance as a “warning” event, TIAs could also furnish the opportunity to act preventatively not only for stroke prevention but also for dementia prevention. In this review, we discuss the current state of the literature regarding the cognitive sequelae associated with TIA, reviewing important challenges in the field. In particular, we discuss definitional and methodological challenges in the study of TIA-related cognitive impairment, confounding factors in the cognitive evaluation of these patients, and provide an overview of the evidence on both transient and long-term cognitive impairment after TIA. We compile recent insights from clinical studies regarding the predictors and mediators of cognitive decline in these patients and highlight important future directions for work in this area.
Influence of Cross-Section and Pitch on the Mechanical Response of NiTi Endodontic Files under Bending and Torsional Conditions—A Finite Element Analysis
Authors: Roda-Casanova Victor , Pérez-González Antonio , Zubizarreta-Macho Alvaro , Faus-Matoses Vicente
Published: May 2022

In this article, the effects of cross-section and pitch on the mechanical response of NiTi endodontic files is studied by means of finite element analyses. The study was conducted over a set of eight endodontic rotary files, whose geometry was obtained from combinations of two cross-sections (square and triangular) and four pitches. Each file was subjected to bending and torsional analyses, simulating the testing conditions indicated in the ISO 3630 Standard, in order to assess their stiffness and mechanical strength. The results indicate that endodontic files with a square cross-section have double the stiffness of those with triangular cross-sections, both in terms of bending and torsion. For both loading modes, endodontic files with a triangular cross-section can undergo larger deformations before overload failure than those with a square cross-section: up to 20% more in bending and 40% in torsion. Moreover, under equivalent boundary conditions, endodontic files with triangular cross-sections present a higher fatigue life than those with square cross-sections: up to more than 300% higher for small pitches. The effect of pitch on the stiffness and strength of the file is smaller than that of the cross-section shape, but smaller pitches could be beneficial when using a triangular cross-section, as they increase the bending flexibility, fatigue life, and torsion stiffness. These results suggest a clinical recommendation for the use of files with a triangular-shaped cross-section and a small pitch in order to minimize ledging and maximize fatigue life. Finally, in this study, we reveal the sensitivity of the orientation of files with respect to the bending direction, which must be taken into account when designing, reporting, and interpreting test results under such loading conditions.
Effects of Remimazolam vs. Sevoflurane Anesthesia on Intraoperative Hemodynamics in Patients with Gastric Cancer Undergoing Robotic Gastrectomy: A Propensity Score-Matched Analysis
Authors: Lee Bahn , Kim Myoung Hwa , Kong Hee Jung , Shin Hye Jung , Yang Sunmo , Kim Na Young , Chae Dongwoo
Published: May 2022

Remimazolam has been suggested to improve the maintenance of hemodynamic stability when compared with other agents used for general anesthesia. This study aimed to compare the effects of remimazolam and sevoflurane anesthesia on hemodynamic stability in patients undergoing robotic gastrectomy. We retrospectively reviewed the electronic medical records of 199 patients who underwent robotic gastrectomy with sevoflurane (n = 135) or remimazolam (n = 64) anesthesia from January to November 2021. Propensity scores were used for 1:1 matching between the groups. The primary outcome was the difference in use of intraoperative vasopressors between groups. Secondary outcomes included differences in incidence and dose of vasopressors, as well as intraoperative hemodynamic variables, between groups. Remimazolam anesthesia was associated with a significantly less frequent use of ephedrine (odds ratio (OR): 0.13; 95% confidence interval (CI): 0.05–0.38, p < 0.001), phenylephrine (OR: 0.12; 95% CI: 0.04–0.40, p < 0.001), and any vasopressor (OR: 0.06; 95% CI: 0.02–0.25, p < 0.001) compared with sevoflurane anesthesia. Remimazolam anesthesia enables better maintenance of hemodynamic stability than sevoflurane anesthesia. Thus, remimazolam anesthesia may be beneficial for patients who are expected to experience hypotension due to the combined effects of CO2 pneumoperitoneum and the head-up position utilized during robotic gastrectomy.
COVID-19 Quarantine Dramatically Affected Male Sexual Behavior: Is There a Possibility to Go Back to Normality?
Authors: Spirito Lorenzo , Morelli Michele , La Rocca Roberto , Napolitano Luigi , Ruvolo Claudia Collà , Romano Lorenzo , di Giovanni Angelo , Sciorio Carmine , Concetti Sergio , Montanari Emanuele , Tripodi Francesca , Fusco Ferdinando , Capece Marco
Published: May 2022

We performed a monocentric longitudinal study on sexually active male patients, from May 2021 to October 2021, with SARS-CoV-2 infection confirmed with a nasopharyngeal reverse transcriptase polymerase chain reaction (RT-PCR). The questionnaires were delivered by email. The study period was divided into the periods before getting tested (T1), during quarantine (T2), 1 month after a negative test (T3), and 3 months after a negative test (T4). All participants were invited to complete these questionnaires: 10- and 6-item questionnaires, a sexual distress schedule (SDS), and the international index of erectile function questionnaire of 15 items (IIEF-15). The primary endpoint was to evaluate the impact of quarantine on male sexual function (SF) during and after the SARS-CoV-2 infection. A total of 22 male patients met the inclusion criteria. The differences for both SDS and IIEF-15 scores, between T1–T2 (27 (IQR 24.0–32.2) vs. 37.5 (IQR 34.2–45.5), 45 (IQR 38.0–50.2) vs. 28.5 (IQR 19.5–38.0)), T2–T3 (37.5 (IQR 34.2–45.5) vs. 28 (IQR 24.0–31.0), and 28.5 (IQR 19.5–38.0) vs. 39.5 (IQR 35.5–44.2)) were statistically significant (p < 0.001), respectively. Moreover, between T1–T4, no statistically significant difference (p > 0.05) was recorded in both SDS (27 (IQR 24.0–32.2) vs. 26.5 (IQR 24–30.2)) and IIEF-15 (45 (IQR 38.0–50.2) vs. 28.5 (IQR 19.5–38.0)). In 20 patients (90.9%), SARS-CoV-2 had a huge impact on relationship and sexual life, but no patient attended a clinic for sexual difficulties. In conclusion quarantine has negatively influenced SF in infected patients; however, 3 months after the rRT-PCR negative test, a promising return to the preinfection SF values is observed.
A Modified Approach for Ultrasound-Guided Thoracic Paravertebral Block via Thoracic Intervertebral Foramen in an Adolescent Patient: A Case Report
Authors: Petrucci Emiliano , Marinangeli Franco , Pizzi Barbara , Sciorio Francesco , Marrocco Gioele , Innamorato Massimo Antonio , Cascella Marco , Vittori Alessandro
Published: May 2022

This case report describes a modified approach for a thoracic paravertebral block by performing a bilateral ultrasound-assisted injection of 12 mL of 0.5% levobupivacaine near the thoracic intervertebral foramen, combined with general anesthesia, in a patient who underwent emergent laparotomy for small intestinal volvulus. Two continuous catheter sets were used for a bilateral continuous block with levobupivacaine 0.25% at a rate of 5–8 mL/h. No complications during the execution of the block were recorded. No supplemental opioids were administered and the patient was hemodynamically stable, requiring no pharmacological cardiovascular support during surgery. At the end of the surgical procedure, the patient received a continuous flow of 0.2% levobupivacaine as postoperative analgesia, at a basal flow of 4 mL/h per each side, a bolus of 4 mL, and a lockout time of 60 min was used. The postoperative pain on the Numeric Rating Scale was 2 at rest and it was 4 in motion, without neurological or respiratory sequelae due to block in the first 72 h after surgery.
Early and Long-Term Outcomes after Propofol-and Sevoflurane-Based Anesthesia in Colorectal Cancer Surgery: A Retrospective Study
Authors: Lee Seungwon , Pyo Dae Hee , Sim Woo Seog , Lee Woo Young , Park MiHye
Published: May 2022

Background: Propofol is considered to protect against immunosuppression and has lower inflammatory responses in the perioperative period than volatile agents. We evaluated whether the anesthetic agent is associated with cancer outcomes. Methods: We retrospectively reviewed 2616 patients who underwent colorectal cancer surgery under general anesthesia between 2016 and 2018 (follow-up closure: July 2021) at a single institution. Patients received propofol-based total intravenous anesthesia or sevoflurane-based inhalational anesthesia. After propensity score matching, the postoperative neutrophil-lymphocyte ratio (NLR) was compared as primary outcome, and clinical outcomes were evaluated. Results: After 1:2 propensity matching, 717 patients were given propofol anesthesia and 1410 patients were given sevoflurane anesthesia. In the matched cohort, preoperative NLR was not significantly different between propofol and sevoflurane anesthesia (mean (95% CI)2.3 (1.8 to 2.8) and 2.2 (1.9 to 3.2); p = 0.72). NLR was significantly lower in propofol anesthesia at postoperative day two and five (mean difference (95% CI) 0.71 (0.43 to 0.98); p = 0.000 and 0.52 (0.30 to 0.74); p = 0.000). Urinary retention showed a higher incidence after propofol anesthesia (4.9% vs. 2.6%; p = 0.008). Other postoperative complications and overall/recurrence-free survival were not different in the two groups. Discussion: Although propofol anesthesia showed lower postoperative NLR than sevoflurane anesthesia, there was no association with clinical outcomes.
Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
Authors: Bar-Haim Erez , Eliakim-Raz Noa , Stemmer Amos , Cohen Hila , Elia Uri , Ness Asaf , Awwad Muhammad , Ghantous Nassem , Moskovits Neta , Rotem Shahar , Stemmer Salomon M.
Published: May 2022

Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boost effect was observed, the high response following the third administration questions the necessity of an early fourth boost.
Oral Care Recommendation for Cystic Fibrosis Patients–Recommendation for Dentists
Authors: Pawlaczyk-Kamieńska Tamara , Borysewicz-Lewicka Maria , Batura-Gabryel Halina , Cofta Szczepan
Published: May 2022

Cystic fibrosis (CF) is a genetic disease that is caused by a defect in the gene coding for the transmembrane cystic fibrosis transmembrane conductance regulator (CFTR). Research papers published so far point out that despite the numerous dental treatment needs of CF patients, there are no oral care guidelines for this group of patients. The aim of the article is to propose standards of dental prophylactic and therapeutic procedures for CF patients in different age groups. Regardless of the CF patient’s age, dental check-ups should be scheduled at least every 6 months. However, taking into account the actual condition of the individual CF patients, therapeutic visits may be scheduled for earlier dates, to provide well-fitting treatment, considering the level of risk of oral diseases. The described management standards may be helpful and may improve the quality of dental care provided to CF patients.
Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies
Authors: Lavelle Joseph , Storan Darragh , Eswara Murthy Varsha , De Dominicis Noemi , Mulcahy Hugh E. , McHugh Louise
Published: May 2022

Psychological intervention targeting distress is now considered an integral component of inflammatory bowel disease (IBD) management. However, significant barriers to access exist which necessitate the development of effective, economic, and accessible brief and remote interventions. Acceptance and commitment therapy (ACT) is a therapy with demonstrated acceptability and a growing evidence base for the treatment of distress in IBD populations. The present paper trialled two brief ACT interventions via randomized multiple baseline designs. Study 1 trialled a single-session ACT intervention (delivered face-to-face and lasting approximately two hours) targeting stress and experiential avoidance, respectively. Participants were seven people with an IBD diagnosis who presented with moderate to extremely severe stress (five females, two males; M age = 39.57, SD = 5.74). The findings of study 1 indicate that a single-session ACT intervention represented an insufficient dosage to reduce stress and experiential avoidance. Study 2 investigated a brief telehealth ACT intervention (delivered via a video conferencing platform and lasting approximately four hours) targeting stress and increased psychological flexibility. Participants (N = 12 people with an IBD diagnosis and mild to extremely severe stress) completed baselines lasting from 21 to 66 days before receiving a two-session ACT telehealth intervention supplemented by a workbook and phone consultation. Approximately half of participants experienced reduced stress, increased engagement in valued action, and increased functioning. Despite shortcomings such as missing data and the context of COVID-19, the present findings suggest that brief ACT interventions in this population may be effective and economic, though further research and replications are necessary.
The Benefit of the Glassy State of Reinforcing Particles for the Densification of Aluminum Matrix Composites
Authors: Kvashnin Vyacheslav I. , Dudina Dina V. , Ukhina Arina V. , Koga Guilherme Yuuki , Georgarakis Konstantinos
Published: May 2022

In metallic glass-reinforced metal matrix composites, the glassy phase can serve a dual purpose: (i) it can behave as soft binder and porosity remover during consolidation; and (ii) it can act as the hard reinforcing phase after densification. The present work aimed to demonstrate the benefit of the glassy reinforcing particles for the densification of aluminum matrix composites. The consolidation behavior of Al–50 vol.% Fe-based alloy mixtures prepared using a glassy Fe66Cr10Nb5B19 alloy powder (Tg = 521 °C, Tx = 573 °C) or a crystalline Fe62Cr10Nb12B16 alloy powder was studied under spark plasma sintering (SPS) and hot pressing (HP) conditions. The powders were consolidated by heating above the glass transition temperature of the glassy alloy (up to 540 °C in SPS and 570 °C in HP). When the coarse aluminum powder was used, the reinforcing particles formed chains within the microstructure. In composites formed from the fine Al powder, the particles of the Fe-based alloy were separated from each other by the metallic matrix, and the tendency to form agglomerates was reduced. The glassy state of the alloy was shown to be beneficial for densification, as the metallic glass acted as a soft binder. The densification enhancement effect was more pronounced in the case of reinforcing particles forming chains. The hardness of the Al–50 vol.% glassy Fe66Cr10Nb5B19 composites obtained by SPS was twice the hardness of the unreinforced sintered aluminum (110 HV1 versus 45 HV1).
Methotrexate-Transferrin-Functionalized Fe(Salen)-Polypyrrole Nanocomposites for Targeted Photo-/Magneto-Thermal Cancer Treatments
Authors: Kim Jeong-Hwan , Umemura Masanari , Eguchi Haruki , Ishikawa Yoshihiro
Published: May 2022

Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received significant interest in targeted cancer therapy. In this study, magnetic Fe(salen)-conducting copolymer nanocomposites based on our previous iron salt-free synthesis method are surface-functionalized with methotrexate and transferrin proteins. The nano-hybrids show near-infrared-/magnetic field-responsive hyperthermal activity in vitro, which can be extraordinarily useful in magnetically guidable local cancer targeting as a versatile multi-modal therapeutic drug delivery system.
Physical and Chemical Characterization of Biomineralized Collagen with Different Microstructures
Authors: Du Tianming , Niu Yumiao , Liu Youjun , Yang Haisheng , Qiao Aike , Niu Xufeng
Published: May 2022

Mineralized collagen is the basic unit in hierarchically organized natural bone with different structures. Polyacrylic acid (PAA) and periodic fluid shear stress (FSS) are the most common chemical and physical means to induce intrafibrillar mineralization. In the present study, non-mineralized collagen, extrafibrillar mineralized (EM) collagen, intrafibrillar mineralized (IM) collagen, and hierarchical intrafibrillar mineralized (HIM) collagen induced by PAA and FSS were prepared, respectively. The physical and chemical properties of these mineralized collagens with different microstructures were systematically investigated afterwards. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) showed that mineralized collagen with different microstructures was prepared successfully. The pore density of the mineralized collagen scaffold is higher under the action of periodic FSS. Fourier transform infrared spectroscopy (FTIR) analysis showed the formation of the hydroxyapatite (HA) crystal. A significant improvement in the pore density, hydrophilicity, enzymatic stability, and thermal stability of the mineralized collagen indicated that the IM collagen under the action of periodic FSS was beneficial for maintaining collagen activity. HIM collagen fibers, which are prepared under the co-action of periodic FSS and sodium tripolyphosphate (TPP), may pave the way for new bone substitute material applications.
Leaching Remediation of Dredged Marine Sediments Contaminated with Heavy Metals
Authors: Wang Zhaowei , Li Bo , Sun Yuanshu , Yang Wenchao
Published: May 2022

There are more than 150 ports in China and a considerable proportion of dredged sediments in ports and waterways are contaminated with heavy metals as the typical contaminants. It is mandatory to remediate the contaminated dredged sediments prior to further resource utilization. The over-arching objective of this study was to use natural organic acids (oxalic acid, citric acid, tartaric acid, and malic acid) as leaching agents to remove heavy metals (Cu, Cd, and Pb) from contaminated dredged sediments. Batch experiments were conducted to investigate the factors governing the removal rate of heavy metals and leaching kinetics. Citric acid had the best leaching effect on heavy metals Cu, Cd, and Pb with an optimal leaching concentration of 20 mmol/L and a solid-to-liquid ratio of 1:20. The average removal rates of Cu, Cd, and Pb were 85%, 73%, 56%, and 35% for citric acid, malic acid, tartaric acid, and oxalic acid, respectively. The leaching kinetics showed that the removal of heavy metals increased rapidly with time and then gradually reached the maximum value which was best described by the Elovich equation model. The outcomes of this study suggest that citric acid is an effective and environmentally friendly leaching agent for removing heavy metals from marine dredged sediments.
Discovery of Pelagic Eggs of Two Species from the Rare Mesopelagic Fish Genus Trachipterus (Lampriformes: Trachipteridae)
Authors: Choi Hae-young , Choi Hee-chan , Kim Sung , Oh Hyun-ju , Youn Seok-hyun
Published: May 2022

The ecology of the mesopelagic fish genus Trachipterus, which is rarely found in oceans, remains unclear. In this study, we found 22 eggs of T. trachypterus and T. jacksonensis around the Ulleung Basin of the East/Japan Sea during ichthyoplankton surveys from 2019 to 2021. The eggs were identified through genetic relationships with the genus Trachipterus based on partial sequences (COI and 16S) or concatenated sequences of 13 protein-coding genes and 2 rRNA genes of mitochondrial DNA. T. trachypterus eggs were discovered in all seasons, but more frequently during the winter. One T. jacksonensis egg that appeared during the autumn was the first in the northwestern Pacific Ocean. Identifying Trachipterus pelagic eggs would provide insight into their spawning ecology and biogeography.
An Improved 1D-VAR Retrieval Algorithm of Temperature Profiles from an Ocean-Based Microwave Radiometer
Authors: Yan Hualong , Zhao Yuxin , Chen Songbo
Published: May 2022

In this study, a one-dimensional variational algorithm that combines brightness temperatures (BTs), measured by ocean-based microwave radiometers (MWR), with reanalysis data was developed to generate high accuracy temperature profiles. A forward radiative transfer model was used to simulate the BTs. For the V band (50–70 GHz), there is a good agreement between observations and simulations, but for K band (20–30 GHz), which is more affected by water vapor, large errors are observed. To reduce the errors, a combined temperature and water vapor background error covariance matrix is applied to the 1D-Var algorithm. In addition, a correction factor is added to the 1D-Var iterative equation to improve retrieval accuracy. The results of the improved 1D-Var method have been compared with the MWR built-in neural network (NN) method, original 1D-Var method, and radiosonde data, which shows that the retrievals of the combined 1D-Var method showed significant improvements between 0 to 10 km. The statistical results show that the maximum mean absolute error of the combined 1D-Var method is less than 2 K in clear sky and cloudy conditions. This paper demonstrates that the proposed combined 1D-Var method has better performance than many known retrieval methods.
Prediction Method and Validation Study of Tensile Performance of Reinforced Armor Layer in Marine Flexible Pipe/Cables
Authors: Wang Hualin , Yang Zhixun , Yan Jun , Wang Gang , Shi Dongyan , Zhou Baoshun , Li Yanchun
Published: May 2022

Marine flexible pipe/cables, such as umbilicals, flexible pipes and cryogenic hoses, are widely adopted in ocean engineering. The reinforcing armor layer in these pipe/cables is the main component for bearing loads, which is a typical multi-layer helically wound slender structure with different winding angles for different devices. There has been no general theoretical methodology to describe the tensile performance of these flexible pipe/cables. This paper first introduces a theory to solve the tensile mechanical behavior of a helically wound structure. Based on the curved beam theory, a solution of the tensile stress of a helically wound slender is derived. Then, the deformation mechanism of the marine flexible pipe/cables structure with different winding angles is studied. Through comparing theoretical and numerical results, the deformation characteristic of the helically wound slender structure is further explained. It is found that a sectional torsional deformation generates when the structure with a larger winding angle is under tension condition, while the sectional deformation of the structure with a smaller winding angle is mainly tension. Finally, a couple types of marine flexible pipe/cables under the tension condition are provided to analyze the mechanical performance and compare the difference between different theoretical models. The research conclusion from this paper provides a useful reference for the structural analysis and design of marine flexible pipe/cables.
Filtration Rates and Scaling in Demosponges
Authors: Riisgård Hans Ulrik , Larsen Poul S.
Published: May 2022

Demosponges are modular filter-feeding organisms that are made up of aquiferous units or modules with one osculum per module. Such modules may grow to reach a maximal size. Various demosponge species show a high degree of morphological complexity, which makes it difficult to classify and scale them regarding filtration rate versus sponge size. In this regard, we distinguish between: (i) small single-osculum sponges consisting of one aquiferous module, which includes very small explants and larger explants; (ii) multi-oscula sponges consisting of many modules, each with a separate osculum leading to the ambient; and (iii) large single-osculum sponges composed of many aquiferous modules, each with an exhalant opening (true osculum) leading into a common large spongocoel (atrium), which opens to the ambient via a static pseudo-osculum. We found the theoretical scaling relation between the filtration rate (F) versus volume (V) for (i) a single-osculum demosponge to be F = a3V2/3, and hence the volume-specific filtration rate to scale as F/V ≈ V−1/3. This relation is partly supported by experimental data for explants of Halichondria panicea, showing F/V = 2.66V−0.41. However, for multi-oscula sponges, many of their modules may have reached their maximal size and hence their maximal filtration rate, which would imply the scaling F/V ≈ constant. A similar scaling would be expected for large pseudo-osculum sponges, provided their volume was taken to be the structural tissue volume that holds the pumping units, and not the total volume that includes the large atrium volume of water. This may explain the hitherto confusing picture that has emerged from the power-law correlation (F/V = aVb) of many various types of demosponges that show a range of negative b-exponents. The observed sharp decline in the volume-specific filtration rate of demosponges from their very small to larger sizes is discussed.
Misjudgment of Skills in Clinical Examination Increases in Medical Students Due to a Shift to Exclusively Online Studies during the COVID-19 Pandemic
Authors: Lechner Axel , Haider Stefan P. , Paul Benedikt , Escrihuela Branz Pablo F. F. , Felicio-Briegel Axelle , Widmann Magdalena , Huber Johanna , Stadlberger Ursula , Canis Martin , Schrötzlmair Florian , Sharaf Kariem
Published: May 2022

In medical school, practical capacity building is a central goal. During the COVID-19 pandemic, a shift to online teaching methods in university was mandated in many countries to reduce risk of SARS-CoV-2 transmission. This severely affected the teaching of psychomotor ability skills such as head and neck examination skills, resulting in a share of students that have only been taught such ENT-specific examination skills with online courses; our study aimed to measure performance and capacity of self-evaluation in these students. After completing a new extensive online Ear Nose Throat (ENT) examination course, we conducted a standardized clinical skills exam for nine different ENT examination items with 31 students. Using Likert scales, self-evaluation was based on questionnaires right before the clinical skills exam and objective evaluation during the exam was assessed following a standardized regime. Self-evaluation and objective evaluation were correlated. To compare the exclusive online teaching to traditional hands-on training, a historic cohort with 91 students was used. Objective examination performance after in-classroom or online teaching varied for single examination items while overall assessment remained comparable. Overall, self-evaluation did not differ significantly after online-only and in-classroom ENT skill teaching. Nevertheless, misjudgment of one’s skill level increased after online-only training compared to in-classroom teaching. Highest levels of overestimation were observed after online training in simple tasks. While gender and interest in ENT did not influence self-evaluation and misjudgment, higher age of participants was associated with an overestimation of skills. Medical students with online-only training during the COVID-19 pandemic achieved similar ENT examination skills to those with traditional on-campus training before the pandemic. Nevertheless, students with online-only training were more prone to misjudge their skills when they assessed their skills. Due to the COVID-19 pandemic, current medical students and graduates might therefore lack individual specific psychomotor skills such as the ENT examination, underlining the importance of presence-based teaching.