bluuebunny/crossref_metadata_2025 huggingface dataset:
Intergenerational wealth transfer and family investment in shadow education: Empirical evidence from housing in China
Authors: Cao XuanHan , Chen Rongeng , Wu Haiquan , Li TianFeng
Published: October 2023

The widespread phenomenon of parents providing housing support for adult children in Chinese society constitutes a form of intergenerational transfer of wealth that constitutes one of the sources of family wealth accumulation and also has an impact on children's investment in education. This paper uses data from the China Household Income Survey (CHIP) in 2018 to examine the impact of intergenerational transfer of wealth in the form of housing support on household spending on shadow education and educational equity. The empirical results of this paper show that housing support significantly increase household shadow education expenditure, and the effect increases after controlling for the "house slave" effect. After solving the endogenous problem with propensity matching score (PSM) and instrumental variable method (IV), the conclusion still holds. Household income, subsistence consumption, and household financial assets constitute the influence channels of the relationship between housing support and shadow education expenditure. The heterogeneity analysis found that housing support had a greater impact on shadow education expenditure among low-income families than on middle- and upper-income families, promoting educational equity. In areas with low pressure on college entrance examinations, the impact of housing support on shadow education expenditure has been further strengthened, weakening educational equity.
Identification of F13A1 and SCCPDH as Potential Diagnostic Markers for Preeclampsia
Authors: Zheng Yihan , Fang Zhuanji , Wu Xizhu , Zhang Huale , Sun Pengming
Published: October 2023

Preeclampsia (PE) is a serious condition that affects pregnant women worldwide. This study aimed to identify diagnostic candidate genes for PE. Gene expression from a PE cohort and controls was analyzed using Limma and weighted gene coexpression network analysis (WGCNA) to identify differentially expressed genes (DEGs) and module genes. Machine learning techniques were then used to identify immune-associated hub genes for PE diagnosis, resulting in the selection of two significant genes (F13A1 and SCCPDH). A nomogram and receiver operating characteristic (ROC) curve were developed to evaluate the diagnostic value, which was high for both hub genes (AUC: 0.9 and 0.88, respectively). A deconvolution study also identified dysregulated immune cells in PE. Overall, this study provides potential diagnostic candidate genes for PE patients and highlights the importance of early diagnosis and treatment for this condition.
Health and non-health benefits and equity impacts of individual-level economic relief programs during epidemics/pandemics in high income settings: A Scoping Review
Authors: Ogunbameru Adeteju , Gebretekle Gebremedhin BeedMariam , Perryman Adrianna , Hassan Marian , Farrell Ashley , Liu Kaun , Mishra Sharmistha , Sander Beate
Published: October 2023

Background
Economic relief programs are strategies designed to sustain societal welfare and population health during a regional or global scale infectious disease outbreak. While economic relief programmes are considered essential during a regional or global health crisis, there is no clear consensus in the literature about their health and non-health benefits and their impact on promoting equity.
Methods
We conducted a scoping review, searching eight electronic databases from January 01, 2001, to April 3, 2023, using text words and subject headings for recent pathogens (coronavirus (COVID-19), Ebola, Influenza, Middle East Respiratory Syndrome (MERS), severe acute respiratory syndrome (SARS), HIV, West Nile, and Zika), and economic relief programs; but restricted eligibility to high-income countries and selected diseases due to volume. Title and abstract screening were conducted by trained reviewers and Distiller AI software. Data were extracted in duplicates by two trained reviewers using a pretested form, and key findings were charted using a narrative approach.
Results
We identified 27,263 de-duplicated records, of which 50 were eligible. Included studies were on COVID-19 and Influenza, published between 2014 and 2023. Zero eligible studies were on MERS, SARS, Zika, Ebola, or West Nile Virus. We identified seven program types of which cash transfer (n = 12) and vaccination or testing incentive (n = 9) were most common. Individual-level economic relief programs were reported to have varying degrees of impact on public health measures, and sometimes affected population health outcomes. Expanding paid sick leave programs had the highest number of studies reporting health-related outcomes and positively impacted public health measures (isolation, vaccination uptake) and health outcomes (case counts and the utilization of healthcare services). Equity impact was most often reported for cash transfer programs and incentive for vaccination programs. Positive effects on general well-being and non-health outcomes included improved mental well-being and quality of life, food security, financial resilience, and job security.
Conclusions
Our findings suggest that individual-level economic relief programs can have significant impacts on public health measures, population health outcomes and equity. As countries prepare for future pandemics, our findings provide evidence to stakeholders to recognize health equity as a fundamental public health goal when designing pandemic preparedness policies.
Time to death and predictors of mortality among under-five children with severe acute malnutrition hospitalized at Mulanje District Hospital in Southern Malawi: a retrospective cohort study
Authors: Pajogo Masuzgo , Ndholvu Miriam , Chamambala Prince , Nyondo Wongani
Published: October 2023

Introduction
Severe acute malnutrition (SAM) is a leading cause of inpatient mortality in children in sub-Saharan Africa (SSA). In Malawi, there is limited data that explains why this is the case. Therefore, this study determined the time to death and its predictors among children under five years of age with SAM admitted at Mulanje District Hospital.
Methods
We conducted a retrospective cohort study by reviewing the medical charts of 454 randomly selected children under five years of age who were admitted to Mulanje District Hospital from January 2017 to February 2021. We collected data using data collection forms and analyzed the data with STATA version 16. Cox proportional hazard regression was used to identify predictors of mortality. A statistical significance was declared at a p-value < 0.05
Results
A total of 7,685 children under five years of age were admitted to Mulanje District Hospital between January 2017 and February 2021. We enrolled and analyzed 454 cases, of which 227 were SAM children and the other 227 belonged to non-SAM children. The overall death rate was 14.8%. For SAM children, the death rate was 8.4%, compared to 21.2% for non-SAM children. The median time to death was 5 days (IQR: 2–8) for SAM and 1 day (IQR: 1–2) for non-SAM children. Among SAM children, shock (AHR: 15.3; CI: 2.08–113.42) and not having received amoxicillin (AHR: 4.15; CI: 1.24–13.90) were significant predictors of death. Among non-SAM children, shock (AHR: 2.33; CI: 1.18–4.6), diarrhoea (AHR: 2.07; CI: 1.00–2.30), oxygen therapy (AHR: 3.17; CI: 1.66–6.05), and not having received amoxicillin (AHR: 20.78; CI: 2.81–153.67) were significant predictors of death.
Conclusion
Clinical and nursing interventions should be more focused on predictors of mortality to address the high incidence of deaths among children under five years of age.
Increased Prevalence of Myasthenia Gravis in a Cohort of Patients with Inflammatory Bowel Disease
Authors: Leitão Antônio Miguel Furtado , Gondim Francisco de Assis Aquino , Thomas Florian Patrick , de Souza Marcellus Henrique Loiola Ponte , Braga Lúcia Libanez Bessa Campelo
Published: October 2023

Background. Co-morbid auto-immune disorders may affect 0.2% of the population. We evaluated the association between myasthenia gravis and inflammatory bowel disease.
Methods. We present the epidemiological, clinical and electrodiagnostic findings of one patient with ulcerative colitis and three with Crohn’s disease (from a Brazilian cohort of 606 patients) and co-morbid myasthenia gravis.
Results.Mean age of onset of inflammatory bowel disease was 33.5+2.7, and patients are currently 45.8+7.3 years old. Two patients were acetylcholine receptor antibody positive, one anti-Muscle specific kinase positive and one seronegative. Three had abnormal repetitive nerve stimulation, all four had normal nerve conduction studies, abnormal skin wrinkling test and mild small fiber neuropathy. None had thymoma and/or accepted thymectomy. According to the Myasthenia Gravis Foundation classification, one was class V, one class IVb and two IIa. Myasthenia gravis diagnosis was masked by immunotherapy in all. The Prevalence ratio of having myasthenia gravis in inflammatory bowel disease patients in comparison with the proportion of myasthenia gravis among all patients seen in our center was 8.56 (P<0.0001, CI=3.1-23.5). Considering the lowest and highest prevalence of myasthenia gravis reported in the literature, the Prevalence ratio is 44.0 (P<0.0001, CI:16.3-118.4) and 26.4 (P<0.0001, CI: 9.8-70.6), respectively.
Conclusions. Myasthenia gravis prevalence is higher in inflammatory bowel disease and may include muscle specific kinase positive disease (first report in the literature). In general, myasthenia gravis clinical course was not significantly modified by inflammatory bowel disease relapses and frequently overlaps with other autoimmune conditions and small fiber neuropathy.
The influence of pre-visit anxiety on patient-provider communication and breast cancer patient uncertainty
Authors: Broadbridge Elizabeth , Venetis Maria K.
Published: October 2023

Purpose: Effective communication between cancer patients and providers is critical for addressing psychological distress, reducing uncertainty, and promoting patient well-being. This is particularly relevant during medical appointments that may elicit uncertainty, such as surgical consultations for newly diagnosed women with breast cancer. This study aimed to evaluate how pre-appointment anxiety affects patient-provider communication in breast cancer surgical consultations and subsequent post-appointment well-being. Breast cancer patient anxiety has been studied as an outcome of provider communication, though less is known about the extent to which pre-existing anxiety acts as an antecedent to effective patient-provider communication.
Methods: This study analyzed videorecorded breast cancer surgical consultations (N = 51) and corresponding patient surveys to understand how pre-appointment anxiety influences pre-appointment patient uncertainty, patient-provider communication during the appointment, and subsequent post-appointment uncertainty.
Results: Overall, patients with elevated pre-appointment anxiety (n = 12) did not have more pre-appointment uncertainty but were interrupted by their provider at a higher rate than those without anxiety. The proposed model achieved good fit to the data such that more pre-appointment anxiety was associated with more pre-appointment uncertainty, more pre-appointment anxiety was associated with more empathic opportunities per minute, and more empathic opportunities were associated with less post-appointment uncertainty.
Conclusions: Results provide new understanding for how patient anxiety acts as an antecedent to effective patient-provider communication and how this affects patient uncertainty post-appointment. Assessing breast cancer patients’ psychological well-being is crucial for identifying those at higher risk of poor health outcomes and providing holistic cancer care.
Effects of foam roller on pain intensity in individuals with chronic and acute musculoskeletal pain: a systematic review of randomized trials
Authors: Santos Inaê Silva , Dibai-Filho Almir Vieira , Santos Patrícia Gabrielle dos , Júnior José Djalma Arrais , de Oliveira Daniella Dias , Rocha Daniel Santos , Fidelis-de-Paula-Gomes Cid André
Published: October 2023

Objective To analyze the effects of using foam roller on pain intensity in individuals with chronic and acute musculoskeletal pain.Methods This systematic review was registered in the National Institute for Health Research's prospective online registry of systematic reviews (PROSPERO) under CRD42023456841. The databases Pubmed, Medline (via Ovid), Embase, BVS, and PEDro (Physiotherapy Evidence Database) were consulted to carry out this systematic review. Notably, the records of clinical trials characterized as eligible were manually searched. The search terms were: (foam rolling OR foam rolling vibration) AND (acute musculoskeletal pain) AND (chronic musculoskeletal pain). The search was performed until August 22, 2023. For the analysis of the methodological quality, the PEDro scale was used for each of the manuscripts included in the systematic review. Due to the heterogeneity in the studies included in this systematic review, performing a meta-analysis of the analyzed variables was impossible.Results Only six manuscripts were eligible for data analysis. The type of FR used was non-vibrational, being applied by a therapist in only one of the manuscripts. With an application time ranging from at least 45 seconds to 15 minutes, the non-vibrational FR was applied within a day up to six weeks. Using the PEDro scale, scores were assigned that varied between 4 and 8 points, with an average of 6 ± 1.29 points. Only two randomized clinical trials found a significant benefit in pain intensity of adding FR associated with a therapeutic exercise protocol in individuals with patellofemoral pain syndrome and chronic neck pain.Conclusion the results of this systematic review do not elucidate or reinforce the clinical use of FR in pain intensity in individuals with chronic and acute musculoskeletal pain.
Caregiver burden, mental health, quality of life and self- efficacy of family caregivers of persons with dementia in Malaysia: Baseline results of a psychoeducational intervention study
Authors: Nasreen Hashima E , Tyrrell Marie , Vikström Sofia , Craftman Åsa , Ahmad Sarifah Amirah Binti Syed , Zin Nora Mat , Aziz Karimah Hanim Abd , Tohit Noorlaili Binti Mohd , A Mohd Aznan Md , Kabir Zarina Nahar
Published: October 2023

Background: The majority of persons with dementia (PWD) are mainly cared for by their family members in the home. Evidence is however scarce on family caregivers’ psychosocial burden and quality of life in Asian countries including Malaysia. This study describes the baseline data of a telephone-delivered psychoeducational intervention study and examines the determinants of outcome measures (caregiver burden, depressive and anxiety symptoms, quality of life and caregiving self-efficacy) among Malaysian family caregivers to PWD.
Methods: The study used the baseline data of a randomized control trial of 121 family caregivers recruited from lists of PWD who were registered at memory and psychiatry clinics in three tertiary care hospitals in Malaysia. The participants were assessed for caregiver burden by the Zarit Burden Interview, depressive and anxiety symptoms by the Hospital Anxiety and Depression Scale, quality of life by the Control, Autonomy, Self-Realization, and Pleasure Scale, and caregiving self-efficacy by the Revised Scale for Caregiving Self-Efficacy.
Results: Prevalence of caregiver burden was 69.4%, depressive symptoms 32.2% and anxiety symptoms 32.2%. Family caregivers to PWD having perceived peer support e.g., social/family/friend/significant other supports were less likely to report caregiver burden, depressive and anxiety symptoms, and more likely to report higher levels of quality of life and caregiving self-efficacy. Being married and PWD’s ability to self-care were associated with lesser likelihood of experiencing caregiver burden, depressive and anxiety symptoms. The other determinants of greater probability of reporting better quality of life were caregivers’ employment and having Islamic faith. Marital status (married), PWD’s ability to self-care, spousal relationship with PWD and shared caregiving process were associated with higher likelihood of reporting caregiving self-efficacy.
Conclusion: Caregiver burden, depressive and anxiety symptoms are prevalent in family caregivers to PWD in Malaysia. Social support and caregiving related factors influence family caregivers’ quality of life and caregiving self-efficacy. Implementing psychoeducational intervention and support in the psychiatry and memory clinics may help improve the psychosocial burden, quality of life and caregiving self-efficacy in family caregivers of PWD.
Trial registration: ISRCTN14565552 (retrospectively registered)
Multiomic traits reveal critical irinotecan-related regulators in colorectal cancer, and irinotecan promotes ferroptosis in colorectal cancer by regulating FSTL3
Authors: Huang Chengyi , Tang Bufu , Lan Huiyin , Chen Jinggang , Shen Haixia , Jiang Jin , Zhu Ji
Published: October 2023

Background：Irinotecan is a widely used chemotherapy drug in colorectal cancer (CRC). The evolution and prognosis of CRC involve complex mechanisms and depend on the drug administered, especially for irinotecan. We aim to explore the specific mechanism and multiomic traits of irinotecan-related regulators, which is beneficial for accurate individualized treatment for CRC.
Methods: Bioinformatics analysis was used to explore the multiomic traits of irinotecan-related regulators. RT‒qPCR, western blotting and flow cytometry were used as experimental validations.
Results: Iriscore (irinotecan-related score) was constructed based on irinotecan-related regulators and a high iriscore predicted a poor prognosis, poor therapeutic response and the MSS/MSI-L status. Single-cell analysis revealed that FSTL3 and TMEM98 were mainly expressed in CRC stem cells. Potential transcription factors (E2F1, STAT1, and TTF2) and therapeutic drugs (telatinib) that target irinotecan-related regulators were identified. FSTL3 was the core risk irinotecan-related regulator. Some ferroptosis regulators (GPX4, HSPB1 and RGS4) and related metabolic pathways (lipid oxidation and ROS metabolism) were correlated significantly with FSTL3. In vitro, irinotecan inhibited the expression of FSTL3 and ferroptotic defence proteins (GPX4 and SLC7A11) and induced lipid peroxidation.
Conclusion: We confirmed irinotecan-related regulators, especially FSTL3, have effective prognostic value in CRC and showed that irinotecan promotes ferroptosis by inhibiting FSTL3, which is beneficial for identifying candidate targeted irinotecan-related regulators and accurate individualized treatment strategies for CRC.
Association of serum Asprosin concentrations with heart failure
Authors: Wang Guoan , Fan Chunzhen , Chai Yaru , Yu Xin , Xing Mingqing , Lv Zhihua , Yuan Shanshan , Dai Hongyan
Published: October 2023

Background To analyze the association of serum Asprosin concentrations with heart failure (HF).
Methods A total of 103 patients with HF were included in the HF group, and 103 patients with health checkups were included in the non-HF group. The serum Asprosin levels of the two groups were measured, and relevant clinical data were collected for statistical analysis.
Results Compared with the non-HF group, the serum Asprosin concentration was significantly higher in the HF group, and the difference was statistically significant (P<0.001). According to the serum Asprosin levels, we divided all the subjects into three quartiles. We found that the prevalence of HF increased with increasing serum Asprosin levels in the three groups (P<0.001). Serum Asprosin levels were positively correlated with NT-ProBNP (P<0.05) and negatively correlated with LVEF (P<0.001). Dichotomous logistic regression analysis found Asprosin to be an independent risk factor for HF (OR =1.010, 95% CI: 1.003-1.018). Combining Asprosin and NT-proBNP indicators to draw ROC curves can improve the specificity and sensitivity of HF diagnosis.
Conclusions Serum Asprosin levels were significantly elevated in HF patients. The serum Asprosin level is an independent risk factor for HF, and the combined detection of Asprosin and NT-proBNP levels can improve the accuracy of HF diagnosis.
Changes in MRI head motion across development: typical development and ADHD
Authors: Thomson Phoebe , Loosley Vanessa , Friedel Emily , Silk Timothy J.
Published: October 2023

Head motion is a major confounding variable for magnetic resonance imaging (MRI) analysis, and is commonly seen in individuals with neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). This study investigated the trajectory of change in head motion in typically developing children and children with ADHD, and examined possible altered trajectories in head motion between children with remitted and persistent ADHD. 105 children with ADHD and 84 controls completed diffusion and resting-state functional MRI scans at up to three waves over ages 9–14 years. In-scanner head motion was calculated using framewise displacement, and longitudinal trajectories analyzed using generalized additive mixed modelling. Results revealed a significant age effect on framewise displacement where head motion decreased as age increased during both diffusion (p < .001) and resting-state functional MRI (p < .001). A significant effect of group was also observed; children with ADHD displayed greater framewise displacement than controls over the age range (diffusion MRI p = .036, functional MRI p = .004). Further analyses revealed continued elevation in head motion in children in remission from ADHD (diffusion MRI p = .020, functional MRI p = .011) compared to controls. Rates of change in head motion did not significantly differ between diagnostic groups. Findings indicate a critical link between in-scanner head motion and developmental age within children regardless of ADHD diagnosis, important to consider in studies of neurodevelopment. Findings also suggest change in head motion with age does not differ between individuals with remitted and persistent ADHD, adding further evidence that impairment/behavioral manifestations of ADHD may continue despite clinical remission.
Effect of Bee Bread on Corticosterone Level in Rat Dams Exposed to Gestational Heat Stress
Authors: Nur Akmar Nadhirah Mohd Nor  , Asmad Kari  , Mohd Nizam Haron  , Connie Fay Komilus
Published: October 2023

Environmental temperature rises are powerful stimuli that can alter both the sympathetic nervous system and the hypothalamic-pituitary-adrenocortical axis (HPA). Heat stress has been shown to harm pregnancy outcomes such as causing spontaneous abortion, low birth weight, growth retardation and stillbirth. Supplementation of bee bread in pregnant rats under heat stress exposure has been shown to improve the pregnancy outcomes. However, whether supplementation of bee bread during heat stress exposure may also reduce the level of the stress hormone, corticosterone has yet been reported. Therefore, this study aims to determine the effect of bee bread on corticosterone level, progesterone level, oestradiol level and zonation of the adrenal cortex of pregnant rats under heat stress exposure. Pregnant rats were randomly categorised into four groups (n = 6): Control (C: standard feeding), Treatment 1 (T1: 0.5 g bee bread/kg body weight/ day), Treatment 2 (T2: standard feeding with heat exposure), and Treatment 3 (T3: 0.5 g bee bread/kg body weight/day with heat exposure). Bee bread (0.5 g/kg body weight/ day) was force-fed to pregnant rats through oral gavage beginning on day 0 of pregnancy and continuing until delivery. Heat stress was generated experimentally by putting both T2 and T3 rats in an egg incubator for 45 min daily at a temperature of 43°C till delivery. On a postnatal Day 21, dams were euthanised to assess serum corticosterone, progesterone, oestradiol levels and adrenal gland histology. Rats in the T2 group had a significantly (P < 0.05) increase in the zona fasciculata thickness (94.95 ± 1.55 ?m) and higher corticosterone levels (49.57 ± 1.57 ng/mL) compared with control. However, supplementation of bee bread during heat stress was able to show an improvement in adrenal zona fasciculata thickness by decreasing to 79.89 ± 3.08 ?m and corticosterone level reduced to 35.31 ± 1.73 ng/mL significantly (P < 0.05). Therefore, these findings may imply that bee bread is effective as a neutralizer in lowering the production of stress hormone.
Magmatic degassing and fluid metasomatism promote compositional variation from I-type to peralkaline A-type granite in the late Cretaceous Fuzhou felsic complex, SE China
Authors: Zhang Feng , Guo Feng , Zhang Xiaobing , Zhao Liang
Published: October 2023

A-type granites generally have much lower water, higher temperature, and incompatible element concentrations than I-type granitoids. Yet it remains unclear why I-A-type granitic complexes occur in convergent plate margins. Here we conduct geochemical analyses on apatite and mafic minerals from the late Cretaceous I-A-type granitic complex in Fuzhou area, SE China, aiming to decipher differentiation, fluid metasomatism, and degassing that primarily control the compositional diversity of felsic magmas. Apatites in both rock types are F-rich and show large H2O and δD variations, i.e., 341–3892 ppm H2O and –325 to +336‰ δD in I-type granitoids; 67–1366 ppm H2O and –251 to +1439‰ δD in A-type granites. H2O in apatite is negatively correlated with La/Sm and Sr/Y in the I-type granitoids, whereas it is positively correlated with Ce and total rare earth element (REE) concentrations in the A-type granites. Once H2O increases up to hundreds of ppm, both rock types show a rapid decrease of H2O/Ce, an increase of F/Cl, and extensive H isotope fractionation.

Arfvedsonite occurs as a late crystallizing mineral in the A-type granite and has much higher contents of Na2O, K2O, F, and high field strength elements (HFSE) than hornblende in the I-type granitoids, indicating the addition of F-HFSE-rich alkaline fluids during its magmatic evolution. The consumption of arfvedsonite and formation of aegirine further indicate the role of fluid metasomatism and H2 degassing via a reaction of 3Na3Fe5Si8O22(OH)2 + 2H2O = 9NaFeSi2O6 + 2Fe3O4 + 6SiO2+5H2.

The combined geochemical data demonstrate that the systematic differences in mineral assemblage, whole-rock composition, magma temperature, H2O content, and δD of apatite between the I- and A-type granites are likely attributed to varying degrees of differentiation, fluid metasomatism and magmatic degassing. The I-type granitoids experienced hornblende, biotite, plagioclase, K-feldspar, and apatite fractionation and close-system degassing. The A-type granite was likely formed from the I-type monzogranitic magma that was metasomatized by the mantle-derived F-HFSE-rich alkaline fluids to produce the peralkaline magma, which further experienced K-feldspar + plagioclase + biotite + apatite fractionation and open-system degassing. Further numerical estimation indicates that the primary magma of Fuzhou granitic complex contained ~3.0 wt% H2O, and the lower water content of A-type granite was likely attributed to strong degassing during its emplacement. Our results indicate that some peralkaline A-type granites can be generated from relatively water-poor I-type granitic magmas by fluid metasomatism and degassing.
La sociedad del cansancio y el rendimiento a la luz del pensamiento de Chul-Han
Authors: Castillo Gutiérrez Maria Consuelo , Montoya Ramírez Juan Carlos
Published: October 2023

De acuerdo con lo que manifiesta Byung Chul Han, estamos permeados por una nueva era, la “sociedad del rendimiento”. El agotamiento está sobresaliendo en esta época actual y el hombre mismo se ha encargado de sobresaturarse para cumplir metas, se encuentra en una guerra consigo mismo. Tal como lo menciona Orozco (2015): La Edad Media estaba regida por la idea de Dios, el siglo XVII por las ideas del contrato social, el siglo XIX era la idea del progreso y la lucha de clases y las bacterias, y el siglo XX fue la era de la inmunología. (p. 170). Con relación al planteamiento de Han, es cierto que estamos en un nuevo paradigma y el hombre está cansado, se ha educado para el rendimiento y no se da permiso para parar, es una competencia que vive a diario y lucha contra sí mismo y siente miedo de no poder cumplir con sus metas.
El individuo que se gesta en la actualidad es impaciente, está saciado de positividad. En el siglo XXI las enfermedades representativas son las mentales y emocionales y se ha perdido la libertad a raíz de vivir en un mundo mercantil. El ser humano se convierte en neurótico, depresivo y ansioso. Por consiguiente, la libertad se pierde cuando se auto explota; como menciona el autor, en el mito de Prometeo la relación de Prometeo con el águila es una relación de autoexploración consigo mismo. Y como expresa en su texto Han, “… el dolor de hígado, que en sí es indoloro, es el cansancio. De esta manera, Prometeo, como sujeto de autoexploración, se vuelve presa de un cansancio infinito. Es la figura originaria de la sociedad del cansancio” (p. 12). El autor se refiere a algunas enfermedades y manifestaciones emocionales como la ira y el enojo; imagina un cansancio que no produce cáncer, sino que es silencioso y se desencadena en un ser ansioso que no tiene paz consigo mismo, que a pesar de sentirse cansado es objeto de rendimiento.
En el desarrollo del libro hace énfasis en ese hombre cansado y con exceso de positividad; también en él se evidencia la pérdida de libertad porque no tiene tiempo para el ocio, el entretenimiento siempre está en piloto automático y reacciona en una hiperactividad y se auto exige hasta sentirse agotado y esto lleva a esa vida del consumismo mercantil, mientras los sistemas de información y comunicación lo han convertido en un “Homo Videns”.
Este artículo recopila brevemente lo expuesto por Chul Han en los planteamientos de unas premisas que emergen de un análisis minucioso, relacionadas con las enfermedades neuronales, la sociedad del rendimiento vs, sociedad del cansancio y el aburrimiento profundo, a partir de los postulados del autor.
Drug Regulation in Top Exporters of Pharmaceutical Products
Authors: Aladysheva Z. A. , Beregovykh V. V. , Meshkovskiy A. P. , Pyatigorskaya N. V.
Published: October 2023

This year, the Russian Federation adopted the Strategy for the Development of the Pharmaceutical Industry for the Period until 2030. The document sets the task of ensuring the production in the country of medicines that are competitive in the domestic and foreign markets, and “realizing the export potential of the pharmaceutical industry.” A feature of the pharmaceutical industry is the significant impact of various aspects of drug regulation on exports of medicines. The purpose of the study is to make an analysis of the experience of foreign countries and to identify the most important elements of drug regulation that contribute to the formation and development of sustainable export of medicines taking in the account the existing oligopoly structure of the export segment of the global pharmaceutical market. Considering the volume and diversity of the data obtained, the study was divided into two parts: an analysis of drug regulation in countries that are leaders in pharmaceutical export and in countries that are called pharma emerging markets. This article examines the features of export of pharmaceutical products and drug regulation, in general, provides an analysis of top exporters and demonstrates the main factors associated with successful pharmaceutical export, and shows current trends being taken by drug regulation authorities to maintain leadership in this area. The identified patterns and regulatory solutions can be used to solve the problems of regional markets at the national level.
Features of new free economic zones in Russia
Authors: Vilenskiy A. V.
Published: October 2023

The relevance of the topic is due to the need to search for and find the most rational approaches, techniques and methods for the entry of new Russian territories into the single economic space of our country, to stimulate their accelerated socio-economic development, to ensure the speedy full restoration of everything that was destroyed by military operations on new territories. It is for this reason that free economic zones-development institutions were created in new Russian territories. We are talking about the Crimean-Sevastopol Free Economic Zone and the Free Economic Zone of the Lugansk and Donetsk People’s Republics, as well as the Kherson and Zaporozhye regions. The purpose of the article is a critical analysis of the characteristic features of free economic zones in the new Russian territories, the identification and systematization of problems associated with these zones, and the development of brief proposals for their resolution. The preferential regime of the new free economic zones combined the benefits and the best conditions for business activities, for the implementation of the customs procedure of the free customs zone, to a large extent already prescribed in the laws and regulations for the Special Economic Zones and Advanced Development Territories of our country. In general, the degree of preferential treatment for participants in new free economic zones exceeds that of other Russian preferential zones- territories created as development institutions. The creation of Free Economic Zones in the new territories of Russia can become an effective mechanism for stimulating economic development and attracting investment. However, for this to happen, it is necessary to solve a number of problems related to the lack of skilled labor, competition and cooperation between regions and the lack of infrastructure, including housing and ports. In the schemes of public-private partnership of Free Economic Zones in the new Russian territories under the conditions of the Special Military Operation, the state with its organizational capabilities and budgetary funds should dominate.
Assessment of Competitiveness and Economic Security Far Eastern Macroregion Subjects
Authors: Sibirskaya E. V. , Oveshnikova L. V.
Published: October 2023

Assessment of Competitiveness and Economic Security Far Eastern Macroregion Subjects Currently, as a result of a special military operation and the introduction of sanctions against Russia, threats to the economic security and national sovereignty of the country have increased. In these conditions, one of the key tools for accelerating its economic development are measures of state regulation of competitiveness and security, where the regional aspect is becoming increasingly relevant. Geographical and other characteristics of the Far Eastern territories are widely used in the scientific literature, the idea is formed that there really exists a macro-regional community called the Far East. An analysis of historical experience and the current situation shows that the importance of the Far East for the Russian economy is enormous. The Eastern territories have been supplying Russia with key raw materials for centuries, providing access to the most important markets of the Asia-Pacific region, and contributing to improving the country’s competitiveness and economic security. The authors propose an approach to assessing the competitiveness and economic security of the Far Eastern macroregion based on the developed system of private indicators.
Opportunities for the Russian Federation to Borrow from the World Experience of Preferential Regimes
Authors: Gagarina G. Yu. , Antonova D. A.
Published: October 2023

The presence of underdeveloped territories, a large number of backward and depressed regions has a direct impact on the economic security of both the regions themselves and the state as a whole. One of the tools for the development of space, which has proven its effectiveness in the practice of application in the world, are special (free) economic zones. The regimes emerging in their territories are commonly called preferential. Moreover, there are no uniform rules for the development of such formations. Each state, when establishing preferential regimes, is guided by its own national legislation, certain development goals, as well as the use of international experience in the formation of special economic zones. The main purpose of the article is to study the issues of the development of territories with preferential regimes, their impact on the economy of the home countries and the possibility of using world experience in the subjects of the Russian Federation to attract investment, create new jobs with the support of propulsive industries and the spread of innovations arising in these zones to the nearest areas.
Households of the Population in the Structure of the Agrarian Economy and the Improvement of their State Support
Authors: Petrikov A. V.
Published: October 2023

Economic growth in agriculture in the last 20 years has been accompanied by a decrease in the share of households in the gross production of basic products. However, these farms are still important for the food self-sufficiency of Russian families and the preservation of rural areas in a habitable state. Based on the data of current statistics and agricultural censuses of 2016 and 2021, the article analyzes the role of households in the production of the main types of crop and livestock products both in the country as a whole and in the context of the subjects of the Russian Federation. It is concluded that despite the general decline in the potential of households of the population, in a number of regions it is these farms that determine the trend of agricultural development. Special attention is paid to the assessment of state support for personal subsidiary farms and non-profit (horticultural, horticultural) associations of citizens, the main directions of its improvement are proposed. In particular, it is pointed out the need to stimulate the transition of high-commodity households to farms.
The Russian Arctic in 2022–2023. New Solutions
Authors: Leksin V. N.
Published: October 2023

The article presents the results of a study of the latest changes in the territory of the most unique macro-region of Russia – the Arctic zone of the Russian Federation. In 2022–2023, socio-political, economic, social and even mental transformations affected all spatial components of our federal state and, especially, the subjects of the Federation and municipalities on the territory of the Russian Arctic. During this period, the country’s leadership, under unprecedented sanctions pressure, managed to urgently adjust the decades-old diplomatic and foreign economic ties and make extraordinary state decisions that stimulate economic activity in all types of economic activities. An example of the effectiveness of this is the innovations in the Russian Arctic, which have become an indicative model of the new course of the development of our state, combining the freedom of market relations and powerful state regulation of the economy, the desire for economic sovereignty and active interstate cooperation, constructive social policy and the imperative nature of spiritual and moral values. Today, what is happening in the Russian Arctic is extremely multidimensional, and therefore, in the limited text space of this article, only a summary assessment of the situation is given and the latest issues of the work of the Northern Sea Route and the Northern Delivery are considered. The Reinformation basis of the study was official documents and publications of 2022–2023.
Features of Transformation Business Demographies of Enterprises in the Modern Economic Space of Russia
Authors: Vazhenin S. G. , Vazhenina I. S.
Published: October 2023

The demography of enterprises (or business demography) is a fairly new scientific direction for foreign and especially Russian economic science. The purpose of the study is to assess demographic business trends in the federal districts of the Russian Federation in 2017-2022. in the context of economic sanctions, the COVID-19 pandemic, NWO in Ukraine. The main trends in the entry and exit of enterprises from the market are identified, the birth rates and official liquidation rates are calculated on average over a 6-year period for all federal districts of the Russian Federation. The authors prove that the demography of enterprises is becoming one of the most important markers of the development of countries and regions. As a result of the study, it was concluded that regional features of the entry and exit of enterprises from the market remain and are largely predetermined by the existing economic potential and structure of the economy of individual subjects of the Russian Federation. The given information and analytical materials are useful in developing measures to improve the effectiveness of managerial decisions in order to increase the mobility of the economy of the country and individual regions, taking into account their territorial identity. Taking into account the identified features of the transformation of the business demography of enterprises across the country will be relevant when developing strategies for the socio-economic development of regions in the context of overcoming the consequences of sanctions.
Formation of a Modern Neoliberal Model of Russia’s Regional Policy
Authors: Goncharova K. S.
Published: October 2023

Over the past 30 years, a significant number of normative legal acts regulating various aspects of spatial development have been adopted in our country; the main ones regulating the key areas of regional development can be called the Decree of President B. N. Yeltsin “On the Main Provisions of Regional Policy in the Russian Federation”, which was in force from 1996 to 2017 and was replaced by the Decree of President V.V. Putin “On the approval of the Foundations of the State Policy of Regional Development of the Russian Federation for the period up to 2025”, adopted in 2017. In this study the individual provisions of the regional policy implemented in modern Russia are revealed. The object of the analysis was published regulatory documents characterizing the state policy of federal authorities in a field of regional socio-economic development. The main methods of work were chosen: analysis and systematization of scientific publications, collection, formalization and analysis of normative documents, traditional (internal and external) and legal analysis, as well as retrospective and comparative methods, generalization and systematization. As a result, the author concludes that the regional policy of Russia corresponds to the neoliberal paradigm of management. Including: a basis of economic policy to date remains, on the one hand, a priority creation of local preferences, on the other – a stimulation of the subjects of the Federation for the development of foreign economic activity; social policy, reduced to the nominal possibility of using a set of social guarantees that are supposed to be linked to a settlement system; a program of measures for a development of federal relations as a whole boils down to establishing a relationship between the degree of efficiency of regional economy and the size of transfer payments from the federal center.
Głosy francuskiego oświecenia o Portugalii i trzęsieniu ziemi w Lizbonie
Authors: Drzazgowska Joanna , Mosakowski Marek
Published: October 2023

Artykuł dotyczy głosów wybranych przedstawicieli francuskiego Oświecenia o Portugalii i trzęsienia ziemi w Lizbonie w roku 1755. Portugalia była wprawdzie postrzegana we Francji jako europejskie mocarstwo, które wydatnie przyczyniło się do rozwoju światowego handlu, była zarazem krytykowana za religijną nietolerancję i fanatyzm. Największą uwagę francuskiego Oświecenia przyciągnęło jednak trzęsienie ziemi w Lizbonie. Nasza analiza tego zagadnienia jest podzielona na trzy części. W pierwszej przyglądamy się francuskim filozofom, którzy odrzucili Opatrzność Bożą i leibniziański optymizm. W drugiej omawiamyteologiczne stanowisko Dularda, który nie negując dobroci i mądrości Boga, widział w tej naturalnej katastrofie jużto Bożą karę, już to konieczną część inteligentnego planu Boskiego stworzenia. W trzeciej części mówimy o Rousseau,który Bożej Opatrzności bronił, obarczając winą za lizbońską tragedię zdegenerowanych ludzi, żyjących w stanie kultury w zbyt wielkiej miejskiej koncentracji.
Film interaktywny: pomiędzy narracją a bazą danych
Authors: Maziarczyk Grzegorz
Published: October 2023

Artykuł omawia wpływ wzajemnego oddziaływania narracyjności i logiki bazy danych na zaangażowanie widza w odbiór interaktywnego filmu cyfrowego na przykładzie trzech niedawno wydanych dzieł z pogranicza filmu i gry komputerowej: Late shift, Bandersnatch i Her story. Odwołując się do koncepcji narracyjności interaktywnej takich badaczy jak Marie-Laure Ryan czy Hartmut Koenitz, autor dowodzi, że cyfrowe filmy interaktywne mogą być rozumiane jako bazy danych zawierające niejednokrotniewzajemnie wykluczające się segmenty narracyjne, które stają się budulcem historii (współ)tworzonej przez widzagracza w akcie odbioru. Paradoksalnie, logika bazy danych może przyczynić się do wzmocnienia narracyjności danego dzieła, co pozwala uznać cyfrowe filmy interaktywne za formę medialną efektywniełączącądwie niejednokrotnie przeciwstawiane sobie formy przekazu informacji.
Hasło „bratniego narodu ukraińskiego” w przekazach informacyjnych oficjalnych mediów rosyjskich w 2022 roku na przykładzie portali informacyjnych
Authors: Mojżyn Norbert
Published: October 2023

Artykuł przedstawia zastosowanie teorii framingu doanalizy przekazów informacyjnych dotyczących pojęcia „bratniego narodu ukraińskiego” stosowanych w mediach rosyjskich na przykładzie dwóch wybranych (reprezentatywnych) rosyjskich portalach informacyjnych należących do wielkich stacji telewizyjnych: russian.rt.com i ntv.ru. Autor dokonuje operacjonalizacji ogólnie przyjętych w medioznawstwie ram newsa: konfliktu, ludzkiego interesu, odpowiedzialności, ekonomii i moralności i dodaje do nich dwie nowe ramy: historyczno-kulturowa i stylistyczno-emocjonalna. Każda z ram jest interpretacyjnym pakietem, nadającym znaczenie prezentowanym sprawom i wydarzeniom. Z przeprowadzonych badań wynika, że najczęściej stosowaną ramą newsów była rama konfliktu (80% – russian.rt.com, 62% – ntv.ru), a najrzadziej – rama konsekwencji ekonomicznych (8%, 8%). Stosunkowo rzadko – w stosunku do oczekiwań – miała zastosowanie rama historyczno-kulturowa (28%, 37%). Badania pozwoliły zdemaskować prawdziwą strategię informacyjną Kremla i oficjalnych mediów rosyjskich w odniesieniu do pojęcia „bratnie narody”, która ukierunkowana została faktycznie na generowanie konfliktu rosyjsko-ukraińskiego.
Strategies to Promote COVID-19 Vaccinations in the United States. A Content Analysis of the „We Can Do This” Campaign Videos
Authors: Saran Weronika
Published: October 2023

In response to COVID-19 vaccine resistance, U.S. states implemented numerous incentives to increase vaccination rates. In addition to financial and non-cash prizes, COVID-19 vaccinations were also promoted through education campaigns. The aim of this article is to analyse the persuasive strategies used in the “We Can Do This” campaign videos to encourage vaccination uptake and examine whether these techniques were effective considering the research on COVID-19 vaccine messaging. The paper analysed 70 campaign videos from 2021 using quantitative and qualitative content analysis. The study found that the videos employed a range of effective persuasion strategies to promote COVID-19 vaccines. Differences and similarities between the most and least viewed spots were also explored.