bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Camphor Derivatives and Its Applications: A Review
Authors: Anjaneyulu Bendi , Sangeeta  , Saini Naina
Published: June 2021

Natural compounds are the prominent sources for the synthesis of abundant biologically
active substances in medicinal chemistry. Camphor exists in two enantiomeric forms
i.e., R and S, or both, which are readily obtainable. Camphor is a small molecule with chirality
property that binds to some active site, together with its low cost and convenience to transform
into synthetically useful derivatives and one of the most important monoterpenoids
widely spread in plants and has been used as starting material for the various camphor based
derivatives which exhibit several biological activities include antimicrobial, antiviral, antioxidant,
analgesic and anti-cancer. Many of those simple derivatives are commercially available
in the form of camphor sulfonic acid or ketopinic acid that can be easily be produced from
camphor. This compound is primarily used as a chiral starting material in the enantiospecific
synthesis of natural products is because of its available methods for the direct or indirect introduction of functionality
at C-3, C-5, C-8, C-9, and C-10 carbon atoms. In this study, heterocyclic compounds derived from camphor are arranged
in different groups as Camphor-Derived Simple Heterocycles, Fused Camphor-Derived Heterocycles, Spiro
Camphor-Derived Heterocycles, Ring Expanded Camphor-Derived Heterocycles and Camphor derived metal complexes.
This study summarizes the transformations of camphor and its derivatives along with their biological activities.
Beneficial Effects of Choline Alphoscerate on Amyloid-β Neurotoxicity in an In vitro Model of Alzheimer’s Disease
Authors: Burgaletto Chiara , Di Benedetto Giulia , Munafò Antonio , Bernardini Renato , Cantarella Giuseppina
Published: June 2021

Background:

Alzheimer’s disease (AD) is the most common form of neurodegenerative
disorder characterized by cognitive impairment, which represents an urgent public health concern.
Given the worldwide impact of AD, there is a compelling need for effective therapies to slow
down or halt this disorder.

Objective:

Choline alphoscerate (α-GPC) represents a potentially effective cholinergic neurotransmission
enhancing agent with an interesting clinical profile in cognitive dysfunctions improvement,
although only scanty data are available about the mechanisms underlying such beneficial effects.

Methods:

The SH-SY5Y neuronal cell line, differentiated for 1 week with 10 μm of all-trans-retinoic
acid (RA), to achieve a switch towards a cholinergic phenotype, was used as an in vitro model
of AD. SH-SY5Y cells were pre-treated for 1h with α-GPC (100nM) and treated for 72 h with
Aβ25-35 (10μM).

Results:

α-GPC was able to antagonize Aβ25-35 mediated neurotoxicity and attenuate the Aβ-induced
phosphorylation of the Tau protein. Moreover, α-GPC exerted its beneficial effects by employing
the NGF/TrkA system, knocked down in AD and, consequently, by sustaining the expression
level of synaptic vesicle proteins, such as synaptophysin.

Conclusion:

Taken together, our data suggest that α-GPC can have a role in neuroprotection in the
course of toxic challenges with Aβ. Thus, a deeper understanding of the mechanism underlying its
beneficial effect, could provide new insights into potential future pharmacological applications of
its functional cholinergic enhancement, with the aim to mitigate AD and could represent the basis
for innovative therapy.
Reading Fluency in Spanish Patients with Alzheimer’s Disease
Authors: del Carmen Pérez-Sánchez María , González-Nosti María , Cuetos Fernando , Martínez Carmen , Álvarez-Cañizo Marta
Published: June 2021

Background:

Reading fluency is essential for our functioning in the literate society in which we live. Reading expressiveness or prosody, along with speed and accuracy, are considered key aspects of fluent reading. Prosodic patterns may vary, not being the same in children learning to read as in adulthood. But little is known about the prosodic characteristics and reading fluency of people with neurodegenerative diseases that causes language impairment and reading difficul- ties, such as Alzheimer’s disease (AD).

Objective:

The aim of this work was to study reading fluency in AD, considering reading speed, ac- curacy and reading prosody.

Method:

The participants were 20 healthy elderly Spanish adults, and 20 AD patients, aged 64-88 years. An experimental text was designed, that included declarative, exclamatory, and interrogative sentences, words with different stresses and low-frequency words. The reading of the participants was recorded and analyzed using Praat software.

Results:

The AD group showed significantly longer reading duration, both at the syllable level and at the word and sentence level. These patients also committed more pauses between words, which were also longer, and more reading errors. The control group showed a variation of the syllabic F0 in the three types of sentences, while these variations only appeared in declarative ones in the AD group.

Conclusion:

The pauses, along with the slight pitch variations and the longer reading times and er- rors committed, compromise the reading fluency of people with AD. Assessment of this reading feature could be interesting as a possible diagnostic marker for the disease.
Zinner Syndrome with Ectopic Ureter Remnant
Authors: Ko Ara , Park Sung Bin , Park Hyun Jeong , Lee Eun Sun
Published: June 2021

Introduction:

Zinner syndrome is a rare congenital abnormality defined by a clinical triad
of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction.

Case Presentation:

Most patients are asymptomatic, but if the cystic dilatation of the seminal vesicle
becomes significant, it can result in urinary symptoms such as dysuria and urinary retention.
This rare developmental anomaly related to mesonephric duct can also present with other abnormalities.

Conclusion:

Here, we report our experience of Zinner syndrome with bladder outlet obstruction
and an ectopic ureter remnant.
Antimetastatic Potential of Quercetin Analogues with Improved Pharmacokinetic Profile: A Pharmacoinformatic Preliminary Study
Authors: Pavlović Nebojša , Milošević Nastasija , Đjanić Maja , Goločorbin-Kon Svetlana , Stanimirov Bojan , Stankov Karmen , Mikov Momir
Published: June 2021

Background:

Urokinase-type plasminogen activator (uPA) system is a crucial pathway for tumor invasion
and metastasis. Recently, multiple anticancer effects of quercetin have been described, including inhibitory activity
against uPA. However, the clinical use of this flavonoid has been limited due to its low oral bioavailability.

Objective:

The objectives of the study were to assess the antimetastatic potential of quercetin analogues by analyzing
their binding affinity for uPA, and to select the compounds with improved pharmacological profiles.

Methods:

Binding affinities of structural analogues of quercetin to uPA receptor were determined by molecular docking
analysis using Molegro Virtual Docker software, and molecular descriptors relevant for estimating pharmacological
profile were calculated from ligand structures using computational models.

Results:

Among 44 quercetin analogues, only one quercetin analogue (3,6,2’,4’,5’-pentahydroxyflavone) was found to
possess higher aqueous solubility and membrane permeability, and stronger affinity for uPA than quercetin, which
makes it a potential lead compound for anticancer drug development. Like quercetin, this compound has five hydroxyl
groups, but arranged differently, which contributes to the higher aqueous solubility and higher amphiphilic moment in
comparison to quercetin. Since membrane permeability is not recognized as the limiting factor for quercetin absorption,
analogues with higher aqueous solubility and retained or stronger uPA inhibitory activity should also be further
experimentally validated for potential therapeutic use.

Conclusion:

Identified quercetin analogues with better physicochemical and pharmacological properties have a high
potential to succeed in later stages of research in biological systems as potential anticancer agents with antimetastatic
activity.
Recent Development and Future Prospects of Molecular Targeted
Therapy in Prostate Cancer
Authors: Hassan Waseem , Zhang Jinku , Sun Jirui , Bakht Sahar
Published: June 2021

:

Prostate cancer (PC) is a rapidly increasing ailment worldwide. The previous decade has
observed a rapid advancement in PC therapies that was evident from the number of FDA approvals
during this phase. Androgen deprivation therapies (ADT) have traditionally remained a mainstay
for the management of PCs, but the past decade has experienced the emergence of newer classes of
drugs that can be used with or without the administration of ADT. FDA approved poly (ADP-ribose)
polymerase inhibitors (PARPi) such as olaparib and rucaparib after successful clinical trials
against gene-mutated metastatic castration-resistant prostate cancer. Furthermore, drugs like apalutamide,
darolutamide and enzalutamide with androgen-targeted mechanism of action have manifested
superior results in non-metastatic castration-resistant prostate cancer (nmCRPC), metastatic castration-
sensitive prostate cancer (mCSPC), and metastatic castration-resistant prostate cancer (m-
CRPC) respectively with or without previously administered docetaxel. Relugolix, an oral gonadotropin-
releasing hormone antagonist and a combination of abiraterone acetate plus prednisone
were also approved by FDA after a successful trial in advanced PC and mCRPC respectively.
This review aims to analyze the FDA-approved agents in PC during last decade and provide a summary
of their clinical trials. It also presents an overview of the ongoing progress of prospective
molecules still under trial.
Variación genética de cuatro especies de árboles tropicales de la Reserva de la Biosfera Selva El Ocote, Chiapas, México
Authors: Ruiz-Montoya Lorena , López-López María Zenaida , Lorenzo Consuelo , García-Bautista Maricela , Ramírez-Marcial Neptalí
Published: June 2021

Antecedentes y Objetivos: La variación genética de especies de árboles es escasamente conocida para los bosques tropicales de México. El objetivo fue analizar la diversidad genética de Brosimum alicastrum (Moraceae) y Sapium macrocarpum (Euphorbiaceae) (especies sucesionalmente intermedias y con dispersión zoocora) y de Cecropia peltata (Cecropiaceae) y Heliocarpus appendiculatus (Malvaceae) (sucesionalmente tempranas o pioneras, con síndrome de dispersión zoocora y anemócora, respectivamente), en la selva mediana subperennifolia de la Reserva de la Biosfera Selva El Ocote (REBISO), Chiapas, México. Métodos: Se amplificaron dos regiones de ADN del gen nuclear ribosomal, ITS 1-2 e ITS 3-4, como marcadores genéticos. El ADN se extrajo de hojas o cambium de árboles de las especies elegidas en tres localidades (subpoblaciones) de la REBISO. A partir de secuencias concatenadas (578 pb), se obtuvieron los estimadores de diversidad y diferenciación genética. Resultados clave: Se registraron ocho haplotipos en B. alicastrum, 12 en S. macrocarpum, cinco en H. appendiculatus y seis en C. peltata. Los valores más altos para la mayoría de los estimadores se presentaron en S. macrocarpum (π = 0.0047, Hd = 0.79, s = 10), y también registró la menor diferenciación entre localidades (Φst = 0.22). Heliocarpus appendiculatus y C. peltata presentaron, valores más bajos de diversidad, pero una mayor diferenciación entre las localidades (Φst ~ 0.80). Conclusiones: En general, el mayor nivel de diversidad genética se registró en S. macrocarpum, especie sucesionalmente intermedia y con síndrome de dispersión zoocora. Se observó una menor variación y mayor diferenciación en las especies pioneras, H. appendiculatus y C. peltata. La variación genética observada se ajusta a un modelo evolutivo neutral, por lo que probablemente el patrón de variación observado se debe a procesos evolutivos aleatorios. No obstante, el síndrome de dispersión y su afinidad sucesional influyen en la distribución espacial de la diversidad genética.
PROFIL KOMPETENSI PRODUKTIF SISWA SMK TKR DALAM RANGKA SERTIFIKASI KEAHLIAN UNTUK PERSAINGAN GLOBAL
Authors: Wakid Muhkamad , Tafakur Tafakur
Published: June 2021

Diberlakukannya Masyarakat Ekonomi ASEAN menuntut kesiapan dan pengakuan kompetensi tenaga kerja untuk menghadapi persaingan bebas. Di Indonesia, pemerintah menargetkan peningkatan jumlah penyelenggaraan SMK untuk menyiapkan lulusan yang siap kerja. Namun faktanya pengangguran lulusan SMK masih tinggi, meskipun banyak sekolah telah melakukan uji kompetensi serta program sertifikasi bagi lulusannya. Untuk melihat uji kompetensi di SMK, perlu diketahui materi uji, asesor, hasil uji, serta sertifikasinya. Penelitian survei dilakukan pada SMK Negeri Paket Keahlian Teknik Kendaraan Ringan (TKR) di DIY. Hasil penelitian menunjukkan: (1) Materi uji kompetensi TKR memiliki 2 model. Model 1 menggunakan 4 soal uji, sedangkan model 2 menggunakan 8 soal, (2) Asesor terdiri dari pihak internal guru produktif dan penguji eksternal dari industri jasa servis kendaraan dan balai latihan kerja. Hasil Uji dilihat dari nilainya sangat baik, namun belum mencerminkan kompetensi sebenarnya. Siswa yang lulus uji mendapatkan sertifikat dari SMK bekerjasama dengan mitranya, yaitu bengkel servis kendaraan, MPKD, dan BLK.Kata kunci: Uji kompetensi, Sertifikasi
PELATIHAN PENELITIAN TINDAKAN KELAS DENGAN VARIASI METODE DAN MEDIA PEMBELAJARAN UNTUK MENINGKATKAN KEMAMPUAN PENULISAN KARYA ILMIAH GURU-GURU SMK NEGERI 3 YOGYAKARTA
Authors: Sofyan Herminarto , Suyanto Wardan , Budiman Agus , Siswanto Ibnu , Gumelar Agung , Ruswanto Wahyu Arya
Published: June 2021

The Community Service Program (PPM) at SMKN 3 Yogyakarta aims to (1) increase the motivation of teachers to conduct action research and write papers, (2) increase teachers’ ability to select and use appropriate learning methods and media to conduct classroom action research, (3) increase the competence of vocational school teachers in writing scientific papers, (4) increase teachers’ knowledge in accessing scientific journals and conference to publish their work. The activity was attended by 25 participants consisting of 16 productive subject teachers and 9 normative/adaptive subject teachers. The activities carried out in the form of presentation of material about the importance of increasing teacher productivity in publishing scientific work to enhance careers, design action research in the classroom by implementing appropriate media variations and learning methods, writing strategies and publishing articles in journals and proceedings, tutorial guidance on writing articles, and the practice of compiling scientific articles. This PPM activity succeeded in increasing the motivation of teachers to conduct research and write scientific papers, improve the ability of teachers to select the right learning media and methods for conducting classroom action research, increase participants’ ability to write articles, increase teachers’ knowledge in accessing scientific journals and conference to publish their work. Participants satisfy to get new knowledge and skills about classroom action research techniques, they are open-minded and wish to further enhance their ability to conduct classroom action research and write articles to be published in proceedings/journals.
HUBUNGAN PRESTASI PRAKEIN SISWA DAN MINAT BERWIRAUSAHA SISWA TKR SMK MUHAMMADIYAH 1 SLEMAN
Authors: Nugroho Anggit Wahyu , Sudiyanto Sudiyanto
Published: June 2021

This study aimed to find out the relationship between internship achievement and entrepreneurial interest among students of light vehicle engineering (LVE) of SMK Muhammadiyah 1 Sleman. This was a correlational study. The research subjects were 70 LVE students at SMK Muhammadiyah 1 Sleman with a total of 70 students. The data were collected using questionnaires and documents. The data were analyzed using product moment statistics. The results of the study showed that the students’ industrial internship achievement was 56% in the good category, their entrepreneurial interest was 53% in the high category, and there was a relationship between the internship achievement and the entrepreneurial interest  among the students of LVE of SMK Muhammadiyah 1 Sleman in the 2018/2019 academic year. The relationship between industrial internship achievement and entrepreneurial interest was classified as a moderate correlation with a Pearson Correlation coefficient of 0.599. The outstanding values were knowledge and expectation of working through entrepreneurship. Meanwhile the weak values were attitude towards and attention to entrepreneurship activities.
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN KEAKTIFAN DAN HASIL BELAJAR PESERTA DIDIK
Authors: Sukirman Sukirman , Solikin Moch.
Published: June 2021

This study implemented the Problem Based Learning learning model to increase the students’ activeness and learning outcomes in the conventional fuel system competency in class XI TKRA SMK Nasional Berbah. A Classroom Action Research (PTK) with Kurt Lewin's model was conducted, and the data were collected using observation, tests, and documentation. The indicator of the success of this study is if more than 75% of students are active and 75% of students reach the minimum score criteria (75). The participants of this study were 32 students of class XI. The results showed that the application of PBL able to increase the students’ activeness and learning outcomes on the competence to understand the conventional gasoline fuel system. This can be seen from: (1) an increase in positive activities (activities that support the implementation of the teaching and learning process) and a decrease in negative activities (activities that interfere with the implementation of the teaching and learning process) in each cycle. Positive activity in cycle I was 51% and cycle II was 76%; (2) there is an increase in the class average and students' learning completeness. The class average in cycle I was 71 and cycle II was 78. Meanwhile, students' learning completeness in cycle I was 43.75%, cycle II was 84.37%.
PENGARUH MODEL PEMBELAJARAN PROJECT BASED LEARNING TERHADAP HASIL BELAJAR DAN KEAKTIFAN BELAJAR SISWA DI SMK NEGERI 1 NGAWEN
Authors: Utama Kiki Okta Dwi , Sukaswanto Sukaswanto
Published: June 2021

This study aims (1) to determine the effect of using the Project Based Learning learning model on learning outcomes in Light Electricity Maintenance subjects at SMK N 1 Ngawen. (2) To determine the effect of the use of Project Based Learning learning methods on learning activeness in the subjects of Maintenance of Electric Vehicle Light in SMK N 1 Ngawen. This research is a quasi experiment with a pretest-posttest Control Group Design research design. The analysis test uses the independent sample T-test and descriptive analysis to describe the learning outcomes data and learning activeness. The results showed that: independent sample t-test on final learning outcomes or post-test obtained t count> t table is 2.964> 1,670. The significance value of the post-test results 0.004 <0.05, then Ho is rejected and Ha is accepted. This means that there is a significant difference between the results of the experimental class post-test with the control class. Then the results of the independent sample t-test on the students activeness obtained the results that t arithmetic> t table is 5.543> 1.670. Significance value t 0.00 <0.05, then Ho is rejected and Ha is accepted. This means that there is a significant difference in student activeness between the control class and the experimental class. Then it can be concluded that there is a significant influence on the project based learning model of learning outcomes learning and learning activeness of class XI students majoring in light vehicle engineering at State 1 Vocational School, Ngawen.
Квантовый транспорт в полупроводниковом нанослое с учетом поверхностного рассеяния носителей заряда
Authors: Кузнецова И.А. , Савенко О.В. , Романов Д.Н.
Published: June 2021

The problem of the conductivity of a thin conductive nanolayer is solved taking into account the quantum theory of transport processes. The layer thickness can be comparable to or less than the de Broglie wavelength of charge carriers. The constant-energy surface has the form of an ellipsoid of revolution with the main axis parallel to the layer plane. Analytical expressions are obtained for the conductivity tensor components as a function of dimensionless thickness, chemical potential, ellipticity parameter, and surface roughness parameters. The conductivity analysis for the limiting cases of a degenerate and non-degenerate electron gas are conducted. The results are compared with known experimental data for a silicon layer.
Rearing and Spawning Technique of Clown Loach (Chromobotia macracanthus, Bleeker 1852) in Research Institute for Ornamental Fish Culture of Depok, Indonesia
Authors: Winarti Mita , Permana Asep , Budi Darmawan Setia
Published: June 2021

The high demand of botia fish (Chromobotia macracanthus) in the market lead to its sustainability in nature being threatened. The purpose of this technical report is to describe the broodstock and spawning techniques of botia fish carried out at the Research and Cultivation Center for Freshwater Ornamental Fish (BRBIH) Depok, West Java. This activity was carried out from December 2019 to January 2020. This study used two female cows with a spawning ratio of 3 : 1. The average length of the female parent is 9.5 cm with an average weight of 33.5 g, while the length of the male parent is 15.3 cm with an average weight of 56.3 g. Spawning is done artificially using ovaprim. The result of this study was the fecundity value of an average of 8 453 eggs / ind. The average FR was 86.15 %, and the average HR was 78.15 %.
COLLECTION AND DISPOSAL OF MEDICAL WASTE IN GBUZ AMUR REGION «ZEYSKAYA HOSPITAL NAMED AFTER B.E. SMIRNOV»
Authors:   TATIANA VIKTOROVNA IVANYKINA Amur State University, IVANYKINA TATIANA VIKTOROVNA , KRASNOPEEVA ANASTASIA VIKTOROVNA ,   ANASTASIA VIKTOROVNA KRASNOPEEVA Amur State University
Published: June 2021

Classes of medical waste are considered, as well as the process of their collection and disposal in the State Medical Institution of the Amur region «Zeyskaya hospital named after B.E. Smirnov». Recommendations for improving the process of waste collection and disposal are offered.
INVESTMENT ATTRACTIVENESS AND INVESTMENT IMAGE OF THE REGION (ON THE EXAMPLE OF THE AMUR REGION)
Authors:   STANISLAV GENNADIEVICH SERIKOV Amur State University, SERIKOV STANISLAV GENNADIEVICH , GANINA TATIANA NIKOLAEVNA ,   TATIANA NIKOLAEVNA GANINA Amur State University
Published: June 2021

The article provides a SWOT-analysis of the Amur Region. In the course of which the positive and negative factors influencing the investment image of the region are highlighted. The dynamics of investments in fixed assets of the Amur Region in 2010-2018 is considered. Recommendations for state authorities of the region aimed at reducing the influence of negative factors on the investment attractiveness and investment image of the region have been developed.
SIMULATION OF BODY FLOW WITH A SEPARATED LIQUID FLOW IN A COMSOL MULTIPHYSICS ENVIRONMENT
Authors:   Irina Vladimirovna Verkhoturova Amur State University, VERKHOTUROVA IRINA VLADIMIROVNA
Published: June 2021

The article presents the results of using the COMSOL Multiphysics environment to perform one of the laboratory works of the Aerodynamics module of the Hydrogas and Aerodynamics discipline. In the COMSOL Multiphysics environment, it is proposed to simulate the process of a laminar flow of a viscous incompressible fluid around bodies of various geometric shapes, which allows you to visually visualize the boundary layer, its separation from the surface of the streamlined body.
O currículo da licenciatura em Ciências Sociais na UFF: apontamentos dos egressos que exercem a profissão docente.
Authors: Moura Maria Paula Baêsso
Published: June 2021

O presente trabalho busca discutir o currículo do curso de Licenciatura em Ciências Sociais da Universidade Federal Fluminense (UFF). Para tal análise usaremos de três estratégias. A primeira, a leitura e a mobilização de autores que discorrem sobre a questão curricular, em específico do curso de Ciências Sociais em sua íntima relação com o bacharelado. No segundo momento, apresentaremos as especificidades do currículo da UFF, em sua última atualização feita em 2018.2, analisando suas modificações. Por fim, examinaremos o que pensam os egressos da universidade que já exercem o magistério, sobre o currículo que os formou. Com isso, pretendemos discutir o currículo do curso, suas contribuições na formação dos estudantes e as lacunas e aspectos que podem ser modificados visando sua melhoria.
Os 10 anos do atual programa de moradia social no Brasil: uma trajetória de (des)caminhos
Authors: Da Silva Ciro Andrade , Gonçalves Rafael Soares
Published: June 2021

O artigo apresenta um estudo do Programa Minha Casa Minha Vida (PMCMV), o principal programa governamental brasileiro, voltado à produção da moradia social na atualidade. Para o estudo utiliza-se de dados coletados a partir de órgãos oficiais, leis, normas, fontes documentais que se refere ao programa. Percebe-se que, embora tenha respondido ao aumento da oferta de habitação social, permitindo a diminuição do déficit habitacional, não previu a participação popular nas etapas de sua implementação e atendeu sobretudo aos interesses das empresas construtoras. O programa em tela acaba repetindo erros do passado, que provocaram forte periferização da moradia social, principalmente nas grandes cidades.
Treating ARDS-associated air embolism: a question of priorities
Authors: Nilès Christopher , Mathieu Daniel , Parmentier-Decrucq Erika ,   Intensive Care Unit and Hyperbaric Center, Lille University Hospital, Lille, France
Published: June 2021

Gas embolism is a potential and often life-threatening complication of central venous catheters. We report a case of air embolism after tearing of the central catheter associated with severe acute respiratory distress syndrome. The severity of the clinical situation meant choices had to be made regarding the order of treatments. This clinical case provided useful eye-openers for patient management regarding the prioritization of treatments as well as the possibilities offered by hyperbaric oxygen therapy.
Nine Sleeps
Authors: Eva Mohn
Published: June 2021

Transcript for NPP 2021 Audio series
A chromosome-level genome of Antechinus flavipes provides a reference for an Australasian marsupial genus with suicidal reproduction
Authors: Tian Ran , Han Kai , Geng Yuepan , Yang Chen , Thomas Patrick , Pearce Coral , Moffatt Kate , Ma Siming , xu shixia , Yang Guang , Zhou Xuming , Gladyshev Vadim , Shi Chengcheng , Liu Xin , Fisher Diana , Chopin Lisa , Leiner Natália , Baker Andrew , Fan Guangyi , Seim Inge
Published: June 2021

The 15 species of small carnivorous marsupials that comprise the genus
Antechinus exhibit semelparity, a rare life-history strategy where death
occurs after one breeding season. Antechinus males, but not females, age
rapidly (demonstrate organismal senescence) during the breeding season
and show promise as new animal models of ageing. Some antechinus species
are also threatened or endangered. Here, we report chromosome-level
genomes of the yellow-footed antechinus Antechinus flavipes. The genome
assembly has a total length of 3.2 Gb with a contig N50 of 51.8 Mb and a
scaffold N50 of 636.7 Mb. We anchored and oriented 99.7% of the
assembly on seven pseudochromosomes and found that repetitive DNA
sequences occupy 51.8% of the genome. Draft genome assemblies of three
related species in the subfamily Phascogalinae, two additional
antechinus species (A. argentus and A. arktos) and the iteroparous
sister species Murexia melanurus were also generated. Preliminary
demographic analysis supports the hypothesis that climate change during
the Pleistocene isolated species in Phascogalinae and shaped their
population size. A transcriptomic profile across the A. flavipes
breeding season allowed us to identify genes associated with aspects of
the male die-off. The chromosome-level A. flavipes genome provides a
steppingstone to understanding an enigmatic life-history strategy and a
resource to assist the conservation of antechinuses.
Felt Sandwich Exclusion for Apical Multiple Muscular Ventricular Septal
Authors: Agematsu Kota , Kaneko Masahiro , Nishimura Yoshiharu
Published: June 2021

Apical multiple muscular ventricular septal defects (VSDs) are difficult
to visualize, and closing these VSDs is technically troublesome. For
these reasons, the surgical outcome of the lesion is unsatisfactory.
Some surgical techniques have been reported to improve the outcome, but
they are not definite. We present a case with atrial septal defect,
multiple muscular and perimembranous VSDs, and pulmonary hypertension
due to high pulmonary blood flow. In the first operation during the
infantile period, the patient received closure of the perimembranous and
muscular VSD through the right atrium and atrial septal defect closure.
However, postoperative pulmonary blood flow was not decreased compared
with that of before the operation, and pulmonary hypertension was also
not improved. In addition to these lesions, tricuspid valve
insufficiency was also observed after the operation. Postoperative
computed tomography showed channels of apical muscular VSDs in the apex
of the right ventricle. In the second operation, exclusion of apex
muscular VSDs using the felt sandwich technique and tricuspid valve
repair were performed. After closing multiple muscular VSDs during the
operation, pulmonary blood flow was significantly decreased, and
pulmonary hypertension was improved as well. After the second operation,
postoperative echocardiography and catheter examination showed decreased
VSD shunt and pulmonary blood flow, resulting in improved pulmonary
hypertension.
THE CURRENT STATE OF PRE-SCHOOL EDUCATION IN RUSSIA AND MONGOLIA
Authors: Вахитова Галия Хамитовна , Леонтьев Эдуард Петрович , Батсуурь Ажрахгуй
Published: June 2021

Рассматривается состояние современного предшкольного образования в России и Монголии. Указано, что в обеих странах предшкольное образование детей – полноправное и полноценное звено государственной системы общего образования. Отмечается важность понимания современных задач дошкольного детства не с позиции подготовки пяти-, шестилетних детей к систематическому обучению именно в школе, а с точки зрения формирования жизнеспособной личности и самоценности дошкольного возраста. Сделан вывод о том, что система предшкольного образования в дошкольных учреждениях Монголии находится на этапе развития, в то время как в России имеется достаточный опыт для распространения и обогащения образовательной системы в целом.

The article considers the state of modern pre-school education in Russia and Mongolia. It is indicated that in both countries, preschool education of children is a rightful and integral part of the state system of general education, which assumes the continuity of the educational process with ensuring a harmonious transition of children from preschool to primary school education. The article focuses on the goals and objectives of the education of children of senior preschool age, formed in the normative documents of Russia and Mongolia, based on personality-oriented pedagogy. The importance of understanding the current tasks of preschool childhood in both state educational systems is noted not from the point of view of preparing five- and six-year-olds for systematic education in school, but from the point of view of forming a viable personality and intrinsic value of preschool age. A comparative analysis of the current state of pre-school education in Russia and Mongolia has shown that both systems focus on the needs and age opportunities of the child, with the right to choose institutions, programs, forms of activity, methods of education and upbringing. It is concluded that the system of pre-school education in preschool institutions in Mongolia is at the stage of development, while in Russia there is sufficient experience to spread and enrich the educational system as a whole.
Optimizing Early Childhood Education in Efforts to Create Superior Quality Human Resources in Indonesia
Authors: Kurnia Rahmi , Nur Rizka Mutiah , Aini Isda
Published: June 2021

Education is something that must exist in each individual. Without the provision of education, a nation cannot become a developed and competitive country in the era of globalization. If the quality of education is low then the quality of the tablespoons will also be low. Education has a very important meaning for the growth of children because children are potential leaders of the nation. In this study, researchers used a type of literature review research and used data obtained from literature studies. The data obtained were analyzed using descriptive analysis method. The results of this study indicate that there are several aspects that need attention in efforts to optimize PAUD in Indonesia, namely regarding the quality of facilities and infrastructure in PAUD institutions, equitable distribution of education in cities and villages, parental awareness about the importance of PAUD, quality of educators in PAUD institutions. Increasing the operational budget of education, equitable distribution of education in cities and villages, increasing parental awareness about the importance of PAUD through counseling and outreach, improving the quality of educators in PAUD institutions can be done through education and training for prospective educators is an effort and effort that can be done to optimize PAUD in Indonesia.Keywords: Early Childhood, PAUD, Government, Educators, Parents
Students’ Attitudes Towards School Subjects With A Special Focus On Physics: The Case Of Poland
Authors:   The Paweł Włodkowic Higher School in Płock, Poland, Błasiak Władysław , Kazubowski Paweł ,   Center of Optics, Optometry and Visual Rehabilitation in Piła, Poland
Published: June 2021

This work presents the results of research on over 5,000 students aged 14–15 that focuses on their attitudes towards school subjects with special regard to physics. It describes the mathematical relationships between an interest in physics and students’ school grades, their plans to choose a profession in which knowledge in physics is needed, an opinion on the usefulness of physics for society and an assessment of the usefulness of the most important formulas from the school curriculum. The average declared interest in school physics, the assessment of its social usefulness and the willingness to choose a profession relating to physics were relatively low. Of the 16 most important formulas taught in physics during the last three years of learning, only 3 formulas were considered useful by the students. The work also presents the ranking of the persons in the history of physics with the greatest impact on the fate of humanity, according to students.
Interaction of a finite crack with shear waves in an infinite magnetoelastic medium
Authors: Panja Sourav Kumar , Mandal Subhas Chandra
Published: June 2021

The aim of this paper is to investigate the interaction of a finite crack with shear waves in an infinite magnetoelastic medium. Fourier integral transformation is applied to convert the boundary value problem for a homogeneous, isotropic elastic material to the Fredholm integral equation of second kind. The integral equation is solved by the perturbation method and the effect of magnetic field interaction on the crack is discussed. The stress intensity factor at the crack tip is determined numerically and plotted for low frequencies. Moreover, shear stress outside the crack, crack opening displacement, and crack energy are evaluated and shown by means of graphs.
Mechanics of air-inflated 3D distance fabric
Authors: Votrubec Vlastimil , Žák Josef
Published: June 2021

3D distance fabrics are modern and promising material for lightweight inflatable structures. The applications are used in sport, boats, tents, construction, military etc. Its advantages are large load capacity per unit weight, stiffness dependent on pressurized air, fail-safe structure. However, the mechanics of inflated fabric panel is not still described enough. This paper gives basic theory and its experimental verification about mechanical behaviour of distance fabrics. The mathematical model of air-inflated distance fabric panel is created based on analytical theory of cylindrical bending of plates. Material data of the fabric required for performing computations of the model are determined from tensile tests. The reliability of the analytical model is experimentally verified. For that purpose the air-inflated fabric panel was made and tested. Results obtained both experimentally and analytically are compared and discussed. The experiment proves the validity of the mathematical model and allows us to predict the behaviour of distance fabrics.
LANGUE/PAROLE
Authors: Caro Cabrera María
Published: June 2021

Langue/parole (2019) es un proyecto fotográfico en proceso de desarrollo paralelamente a otros con los que se complementa conceptualmente. Forma parte de una investigación en torno a los elementos verbales del paratexto y sus relaciones entre sí, destacando en este caso el elemento fotográfico en adopción de un supuesto papel de «figura».
Családközpontúság és ágazatközi együttműködés a koragyermekkori intervencióban
Authors: Kereki Judit , Kispéter Lászlóné
Published: June 2021

A korai életévek, az egészséges életkezdet támogatása a hosszú távú egészség biztosításának feltétele. A speciális támogatást igénylő gyermekek és családjaik a kora gyermekkori intervenció rendszerében kapják meg azokat az ellátásokat, amelyek sajátos szükségleteik alapján megilletik őket. A korai életszakaszban nyújtott prevenciós és intervenciós szolgáltatások minősége kiemelt jelentőségű a gyermek fejlődése és a társadalom jövője szempontjából.
Hogyan előzzük meg a gyermekbántalmazást? A prevenciós munka jelentősége és kihívásai
Authors: Toma Andrea , Kovács Zsuzsanna , Domján Gyula , Gadó Klára , Soósné Kiss Zsuzsanna
Published: June 2021

A gyermekbántalmazást a WHO népegészségügyi problémának minősítette. A cikk a fogalmi meghatározások és a rövid történeti áttekintés mellett a hangsúlyt a prevenciós lehetőségek bemutatására és annak nehézségeire helyezi. Ismerteti a magyar törvényi kereteket, a hatályos módszertani irányelveket. Rávilágít a jelzőrendszeri tagok szerepére, feladataira, különösképpen a jelzési kötelezettségre, annak törvényi felelősségére.
Song Translation Analysis as a Means for Intercultural Connectivity
Authors: Aronson Greg , Box Kiernan
Published: June 2021

In an increasingly interconnected and globalised world, the need for cross cultural understanding is greater than ever before. Exploring and analysing songs from different cultures can be an effective ‘entry point’ into learning about the nature of other peoples and societies lives and for developing a sense of ethnocultural empathy. Protest songs can provide a lens for intercultural analysis, especially for understanding minority or subcultural perspectives. Translating songs into different languages makes these works more accessible to a broader cross-section of people. We present translations of protest songs, two from Indonesian to English, and one from English to Indonesian. We discuss the respective importance of meaning and poetics in making song translations. Strict adherence to song rhymes is a challenge for translators and one which may impede meaning. The optimal approach depends on the format in which the translation is likely to be presented. Fluency in the target language, rather than the source language, is more helpful for successful translation. Finally, we make some recommendations about the usefulness of intercultural song (text) translation analysis and intercultural awareness.
Aspectos do percurso histórico da vedação ao enriquecimento sem causa no direito brasileiro
Authors: Silva Rodrigo da Guia
Published: June 2021

O escopo central do presente estudo consiste na investigação da origem da regra da subsidiariedade da ação de enriquecimento sem causa (atributo atualmente insculpido no art. 886 do Código Civil brasileiro). A esse objetivo central se associa o propósito de investigar a origem do encontradiço entendimento segundo o qual a subsidiariedade constituiria traço marcante e essencial do inteiro instituto da vedação ao enriquecimento sem causa. Imbuído de tais propósitos, o artigo empreende um esforço de análise crítica do percurso histórico do enriquecimento sem causa no direito brasileiro, a partir do exame dos Códigos Civis de 1916 e de 2002. Tal investigação do percurso histórico do instituto na experiência brasileira conduz à conclusão de que a recorrente enunciação da regra da subsidiariedade da vedação ao enriquecimento sem causa padece, em sua gênese, da importação, para a disciplina de um instituto positivado, dos atributos tradicionalmente associados à categoria dos princípios gerais do direito. Ao término da empreitada, busca-se destacar a relevância da análise histórica para o fornecimento de subsídios à necessária renovação do estudo do fenômeno restitutório no direito brasileiro.
A execução provisória da pena no Brasil e os Mandados Internacionais de Criminalização
Authors: Paulino Galtienio da Cruz
Published: June 2021

Este artigo pretende discutir a relação entre a execução provisória de uma sentença penal, adotada pelo Supremo Tribunal Federal no HC 126292 / SP, e a proteção internacional dos direitos humanos, em razão dos mandados internacionais de criminalização. Primeiramente, serão feitas considerações sobre a proteção internacional dos direitos humanos e os mandados de criminalização. Em seguida, serão expostos o conteúdo e os fins dos mandados de criminalização. Por fim, será estabelecida uma relação entre os mandados de criminalização e a execução provisória da pena no Brasil, demonstrando que o novo entendimento do STF é o que melhor se adéqua à proteção dos direitos humanos.
Objeção religiosa:
Authors: Nistler Regiane , Machado Marco Augusto Ghisi
Published: June 2021

O presente trabalho teve como objetivo analisar a objeção de consciência de base religiosa frente à transfusão de sangue em pacientes adultos inconscientes ou incapazes, e, o posicionamento médico diante dessa recusa. Para isto, estabeleceu-se a seguinte problemática: quais os limites da objeção da consciência religiosa e médica em situações de transfusão de sangue em paciente adulto ou incapaz? Trabalha-se com a hipótese de que o direito à vida preponderará frente à recusa à transfusão de sangue, em caso de iminente risco de morte, por motivos de convicção religiosa. Como análise metodológica, o método de abordagem utilizado neste trabalho foi o dedutivo.
As consequências do reconhecimento da ilicitude da prova no processo penal brasileiro à luz da Lei 13.964/19 (Pacote Anticrime)
Authors: Kiss Vanessa Morais , Zonta Fernando de Oliveira
Published: June 2021

A Lei nº 13.964/19 introduziu no Código de Processo Penal, entre outros, o dispositivo que veda a participação no julgamento do caso do juiz que teve contato com a prova considerada ilícita. Trata-se de mudança que dialoga com outras alterações trazidas pela nova legislação, tal como a criação da figura do juiz de garantias em nosso sistema. Este trabalho busca compreender os desdobramentos da nova disciplina a partir de uma leitura sistemática e constitucionalmente orientada, adotando-se a concepção de prova enquanto meio para a captura psíquica do juiz, e valendo-se do referencial teórico fornecido pela exclusionary rule oriunda da jurisprudência estaduninense.
DISTRIBUTIVNI CENTRI – LOGISTIČKI PROCESI I POKAZATELJI
Authors: Samardžija Jelena
Published: June 2021

U ovom radu težište je na proučavanju uloge koju distributivni centri mogu imati u distribuciji robe, logističkim procesima koji se mogu realizovati i pokazateljima njihovog rada.
The emergence and evolution of community energy planning in Canada: Introduction to a special issue
Authors: Calvert Kirby , Kantamneni Abhilash , McVey Ian
Published: June 2021

The push for decarbonization in Canada’s energy system is driving rapid social and technological innovation in the energy sector. Community energy planning is a rapidly evolving social movement and governance innovation that aims to minimize the impacts and maximize the benefits of these structural changes. This brief introduction to the special issue provides an overview of core principles, challenges, opportunities, and questions that surround community energy planning in Canada. Contributions to the special issue are summarized and situated in the context of this broader perspective. Issues for future research are identified.
Auto-percepción de la eficacia en la escritura de alumnos sordos y oyentes de Educación Primaria y Secundaria
Authors: Gutiérrez Cáceres Rafaela
Published: June 2021

Introducción. En este artículo se muestran algunos de los resultados más relevantes de una investigación centrada en el análisis de la auto-percepción sobre su eficacia en la expresión escrita por parte de los alumnos sordos y oyentes, la cual es fundamental para el adecuado desarrollo del complejo proceso escritor y de la calidad de los textos escritos.Método. Los sujetos investigados fueron 116 alumnos: 25 de Educación Primaria y 91 de Educación Secundaria Obligatoria; 15 sordos y 101 oyentes. El proceso de recogida de datos ha consistido en la aplicación adaptada de una escala graduada sobre la auto-percepción de la eficacia en la escritura, de 10 ítems. En cuanto al procedimiento de análisis, se ha llevado a cabo una comparación y confrontación de las habilidades motivacionales del alumnado en función del nivel instructivo así como del status “sordo/oyente”.Resultados. En el análisis de resultados se ha encontrado que, en términos generales, los estudiantes sordos y oyentes de Educación Primaria y Secundaria desarrollan de manera positiva la percepción de su propia eficacia escritora. No obstante, existen unas matizaciones significativas dadas la variabilidad en las respuestas a cada uno de los ítems de la escala, así como también la diversidad existente entre el alumnado.Discusión y Conclusión. Ante la ausencia de este tipo de estudios es preciso insistir en la necesidad de realizar investigaciones centradas en el análisis específico de los componentes afectivos de la escritura en alumnos sordos, atendiendo a los factores individuales y contextuales.
Nonverbal communication in classroom interactions: A pedagogical perspective of touch
Authors: Stamatis Panagiotis J.
Published: June 2021

This paper begins by exploring touch as “tactile perception” dimension, which means what human hands could achieve, especially considering the important role of skin receptors. The author moves forward to a description of children’s necessity for contact as well as to their touch disorders. Following descriptions further clarify these items in the context of human touching behavior. The aim of the present article is to underline the touch dimensions, which needs clarification for the benefit of the development of an appropriate touching behavior between teachers and children, as a strategy of children pedagogical support and as a factor for improvement in classroom interactions according to attachment theory. The review of the professional literature relevant to our research question helps us contextualize the educational value of touching as an educative strategy that contributes to the improvement of the classroom atmosphere. This is because appropriate touching in early childhood relates to the development of positive feelings both in teachers and students, which is remarkable and exceptionally useful for any educational interaction that is expressed into the teaching framework or the educational environment.