bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengendalian mutu agreggat klas A pada pekerjaan rekontruksi(REKON) paket Bulu-tuban-sadang,km 100+300-100+500 kiri dan 105+400-105+500 kanan,tahun anggaran 2022
Authors: Parengkuan Fery , Al Huda Azis
Published: May 2023

Pengendalian mutu adalah faktor penting untuk mendapat informasi sebagai acuan, apakah pekerjaan di lapangan sudah sesuai dengan yang diharapkan. Adapun bentuk pengujian laboratorium yang harus dilalui untuk mengetahui mutu agregat kelas A, yaitu pengujian kestabilan tanah (Atterberg), analisa saringan,abrasi,uji coba pemadatan, California Bearing Ratio (CBR), dan pengujian lapangan dengan metode sand cone test. Pengendalian mutu ini berpatokan pada Spesifikasi Umum tahun 2010 (rev.2) yang dikeluarkan oleh Kementerian Pekerjaan Umum melalui Direktorat Jenderal Bina Marga Republik Indonesia. Peneletian ini dilakukan pada pekerjaan paket preservasi jalan Bulu-Tuban-Sadang tahun 2022, tepatnya pada pekerjaan aggregate kelas A, rekontruksi Km 100+300 – 100+500 kiri dan Km 105+400 – 105+500 Kanan. Hasil yang didapatkan untuk material aggregate kelas A, menunjukan semua tempat ada di nilai kadar air antara 6,0% sampai 10,0%. Sesuai acuan spesifikasi, dan kadar air harus berada di kisaran 3% lebih rendah dari kadar air optimum dan 1% lebih tinggi dari kadar air optimal, yaitu pada kisaran 6,0% - 10,0% berat kering maksimum aggregate kelas A, ɣd (lab) yang direncanakan 1,964%  gc/cc dengan nilai kepadatan 100%, hasil test kepadatan antara ɣd = 99,9 %  gc/cc sampai 101,0%  gc/cc. Untuk material aggregate kelas A yang  memiliki kadar air diluar rentang  6,0% - 10,0%  adalah  Km 100+300 kiri – 100+500 kiri = 9,7% dan Km 105+400 kanan – 105+500 kanan = 8,6%. Berat kering maksimum aggregate kelas A ɣd (lab), direncanakan 1,964%  gc/cc dengan nilai kepadatan lebih dari 95%.
Rencana Peningkatan Desain Struktur Jalan Menggunakan Metode Analisa Komponen Pada Ruas Jalan Kronto – Wonorejo Kabupaten Pasuruan
Authors: Thohari Amin , Garside Annisa Kesy
Published: May 2023

Ruas Jalan Kronto – Wonorejo yang berada di Kecamatan Lumbang, Kabupaten Pasuruan merupakan jalan milik kabupaten yang merupakan jalur industri, memerlukan pengembangan Food Estate dan sentral Produksi Pangan. Jalan dengan panjang ruas 5.630 m ini mengalami kerusakan cukup berat, sehingga memerlukan rencana perbaikan jalan dengan desain yang memadai untuk jalan yang di gunakan sebagai jalur industri. Dalam hal ini perlu adanya kajian untuk desain perkerasan Jalan Lentur yang ideal untuk ruas jalan Kronto – Wonorejo dengan menggunakan metode Analisa Komponen ( Bina Marga) dengan melihat jenis kerusakan, data LHR ( Lalu Lintas Harian Regional ), dan data – data kriteria jalan serta data tanah dasar dan data- data lain yang diperlukan untuk menentukan desain perkerasan jalan. Sehingga bisa di ketahui hasil tebal desain perkerasan lentur yang akan digunakan.
Metode Pengeboran Sumur Dilokasi Berbatu pada Sumur Dalam
Authors: Hariyadi Sugeng , Mokhtar Ali
Published: May 2023

Kami telah melakukan Pelaksanaan pengeboran sumur dalam dan penelitian tentang analisis perhitungan volume air pada pekerjaan sumur ini. Penelitian ini merupakan suatu contoh penelitian tentang analisis karakteristik sumur bor pada Pekerjaan Tempat Pengolahan Sampah Terpadu (TPST). Dimana lokasi tersebut dengan kontur tanah berbukit dan terdapat batu2 gunung di daerah tersebut yang berada didalam tanah. Lokasi ini dipilih oleh Pemerintah terkait karena merupakan Aset dari pemerintah Kabupaten. Dan lokasi tersebut sudah dilakukan survey mengenai Amdal dan DED sangat cocok, dan mendapat dukungan masyarakat dan Lurah setempat. Pekerjaan ini berada di Desa Balak, Kec. Songgon, Kabupaten Banyuwangi, persisnya yang berada 32 km selatan pusat kota Banyuwangi. Tujuan dari penelitian ini agar kami mendapatkan Volume air tanah sesuai kebutuhan selama operasional TPST. Air bersih dari PDAM yg ada selama ini hanya mampu untuk kebutuhan masyarakat sekitarnya maka untuk Pembangunan dan Operasinal diadakan Pencarian air bersih dengan methode Pengeboran sumur dalam dilokasi ini.
Evolution of the architecture of the Crimean Isthmus fortifications in the XV – mid XVIII centuries
Authors: Panukhin Petr V.
Published: May 2023

Введение. Рассматривается процесс эволюции архитектуры Перекопской фортификационной линии (Крым) со времен ее основания князем Владимиром, строительства Турцией и до реконструкции в эпоху Российской империи. Важное стратегическое положение Перекопского перешейка явилось определяющим фактором строительства на нем мощных укреплений в различные исторические эпохи. Последовательно анализируются основные этапы строительства вала и крепости Перекоп во времена походов русских князей на Константинополь, в период владения Крымским полуостровом османами и в эпоху Российской империи. Исследуются методика строительства предполья, рва, вала, куртин, башен и цитадели крепости Перекоп; метрологические закономерности ее объемно-пространственной композиции и строительные материалы, использованные при возведении вышеуказанных укреплений. Также подчеркивается, что система фортификаций Перекопского перешейка служила одной из первых русских укрепленных линий, значение которой актуально и в настоящее время как буферного пространства, отделяющего Крым от материка.

Материалы и методы. На основании изучения исторических письменных, графических и литературных источников и метрологического анализа объемно-пространственной композиции крепости Перекоп исследуются архитектурные, строительные, планировочные и конструктивные особенности фортификаций Крымского перешейка.

Результаты. Выявлены три этапа эволюции фортификационных сооружений Крымского перешейка: 1) русские острожные укрепления земляного вала Перекопа X–XV вв.; 2) турецкая крепость Ор-Капу XVI–XVII вв.; 3) укрепленная линия, построенная по системе Вобана русскими военными инженерами в XVIII в. Раскрыты стратегические причины модернизации перекопских укреплений. Проведен сравнительный анализ планировочных и строительных приемов, используемых на каждом этапе реконструкции крепости.

Выводы. Пристальный интерес к укреплениям Перекопа на протяжении более восьми веков был обусловлен стратегическим пространственным позиционированием Крымского перешейка как «Ворот Крыма» со стороны материка и требовал использования самых передовых фортификационных технологий в условиях постоянной модернизации, связанной с совершенствованием осадной военной техники. Перекопские укрепления не утратили своего стратегического пространственного значения и в настоящее время.
Logarithmic decrement of vibrations of aluminum alloy bridges
Authors: Korgin Andrey V.
Published: May 2023

Introduction. The paper presents the materials of theoretical analysis and the results of experimental studies of determining the values of the logarithmic decrement of vibration of aluminum alloy bridges, which is a key factor in calculations of bridge structures for dynamic effects. In the regulatory documentation of the Russian Federation on design of aluminum alloy bridges, there are no data for determination of logarithmic decrement of vibration. The content presents the results of research on this issue and recommendations for eliminating this shortcoming and improving the current regulatory documentation of the Russian Federation.

Materials and methods. The factors influencing the values of the logarithmic decrement of aluminum bridge structures have been studied, recommended values of the logarithmic decrement of bridge vibrations depending on the materials used and design solutions are given. The results of analysis of field researches of dynamic parameters of three pedestrian bridges made of aluminum alloy 1915 T1: the bridge with a span of 40.1 m across Ryazanskaya st. in Tula and two bridges with span of 10 m in the floodplain of the Yauza river in Moscow, conducted by the NRU MGSU in 2020 are presented. The bridges have load-bearing structures in the form of vertical side trusses with a triangular diagonal lattice. To identify the values of natural frequencies the bridges were studied in the mode of natural vibrations caused by impact force. Velocities of the motions of characteristic points of the bridges were recorded on the basis of which after computer processing the values of frequencies and decrements of natural vibrations have been calculated.

Results. During dynamic tests of the studied aluminum alloy bridges 1915 T1, it has been established that each frequency of the natural vibration corresponds to the value of decrement. By increasing the bridge span values of natural frequencies and their corresponding decrement values significantly decrease, the values of the decrements for the first frequency are affected by the supporting conditions, for the second frequency, the values of the decrements depend only on the material properties and the construction solution.

Conclusions. Decrease of vibration decrement values leads to increase of material consumption to ensure standard operating conditions. When designing complex and critical bridge structures using high-strength aluminum alloys the decrement values should be established in the course of scientific and technical support and experimental research of these alloy grades.
Monitoring and forecasting the condition of structures in the small river basins in southern Russia
Authors: Ivankova Tatyana V. , Fesenko Lev N.
Published: May 2023

Introduction. The southern regions of Russia need to adapt to higher peak river flows and flash floods. Since 1960, the number of recorded flood events has increased. The intensity and severity of flood events tend to decrease, but their annual frequency is increasing. This illustrates the social component of flooding. Trends in the number of flood events are closely related to the increasing population in river valleys. “Integrated management” of construction sites in river basins is based on three elements: monitoring, forecasting and early warning, vulnerability assessment, mitigation and response. The purpose of this study is to establish means of prediction, risk assessment of operational construction projects in river basins taking into account the current natural and climatic factors. Materials and methods. The research is based on the factual material collected in the field studies in the river basins of recreational regions of southern Russia. Design, construction and operational documentation of complex structures was analyzed and their structural elements were evaluated. Results. On the basis of the carried out theoretical, field and numerical researches, the problem of increasing ecological safety of the urban environment was solved by monitoring, assessing, ranging of the technical condition of building structures and forecasting risks in the urbanized areas of river basins. The results of the research should be considered as a basis of practical methods for the complex estimation of ecological safety of natural and technical system of river basins. Further development of the topic can be connected with the scaling studies of urbanized territories, monitoring crisis sites and forecasting of the further condition of construction projects by subjects. Conclusions. The developed software package has practical importance, the product is implemented in the Republic of Crimea, in the operation of the long-term operated HES complexes of the Partizanskoe reservoir supplying water to the city of federal importance Simferopol and the Alminsky reservoir irrigating Bakhchisaray region of the peninsula and it is also being tested in the Krasnodar Territory, the Republic of Dagestan, the Stavropol Territory and Caucasian Mineral Waters.
Numerical simulation of sea-wave diffraction with random phases on breakwaters
Authors: Gogin Aleksandr G. , Kantarzhi Izmail G.
Published: May 2023

Introduction. Numerical simulation of sea gravity waves interaction with seaport barriers using modern numerical wave models is considered. The predictive power of some commonly used models is examined in relation to the diffraction of sea waves with a random phase in comparison with known analytical methods and experimental data.

Materials and methods. Numerical simulation is carried out using modern numerical wave models implemented in the DHI MIKE 21 software package. A spectral wave model with a function for correcting wave diffraction in shallow water and a phase-resolving wave model based on the Boussinesq equations are used.

Results. Distribution of diffraction coefficients behind the breakwaters of the conventional port water area has been obtained for all models. As a result of the comparison, it was found that models of irregular waves (waves with random phases) have better wave energy distribution behind the breakwaters as compared to regular (monochromatic) wave models. It is noted that the type of frequency distribution of random waves has almost no effect on the diffraction coefficients of the water area, while the angular distribution, on the contrary, has a significant effect.

Conclusions. The wave model based on the Boussinesq equations in the irregular wave approximation is determined as the numerical wave model with the best predictive ability. The spectral wave model with diffraction correction function, which is less demanding on computer power, also made it possible to obtain results close to the reference ones. It is confirmed that regular wave propagation modelling of sea waves can give incorrect results in those seaport water areas where wave diffraction effects are strong.
Consideration of anisotropic properties of pebble soils in calculations of stability of slopes of soil dams
Authors: Bestuzheva Alexandra S. , Abduloev Alisher B.
Published: May 2023

Introduction. The results of experimental studies of the deformation and strength anisotropy of gravel-pebble soil laid in the body of soil dams are presented. In the course of stabilometric tests, different shear angles for the stone were obtained with different orientations of soil particles in the working chamber — horizontal and vertical. With an increase in the hydrostatic pressure in the working chamber to 0.8 MPa, a decrease in the shear angles of the stone by 8–12 degrees was obtained, depending on the direction of the soil layering.

Materials and methods. During the processing of experiments, a function of the ratio of shear angles for a stone with different particle orientations, depending on the direction of the main stress at the shear site, was obtained as

ψan = φ(min)/φ(max) = f(σ). Graphs of “hodographs of shear angles” are constructed to determine the calculated values of the strength characteristics of gravel-pebble soil, depending on the angle of inclination of the shear site to the axis of soil layering. The author’s calculation program ОТКОС_Ani (Delphi) has been compiled, taking into account the strength anisotropy of pebble soils for calculating the stability of slopes of soil dams and slopes.

Results. For stone and stone-earth dams of different designs and heights, slope calculations were carried out and correction coefficients were obtained to account for strength anisotropy in slope stability calculations in the form of a function kan = Knan / Kn = f(H, γ, m).

Conclusions. The functions of the kan change depending on the type, height and density of the gravel-pebble soil laying in the body of the dam are obtained. It is found that the “lowering” coefficient for taking into account the decrease in the strength properties of pebble soil with horizontal layering varies in the range from 1 to 0.9, which should be taken into account when choosing the design of soil dams with prisms of gravel-pebble soils.
Review of methods for predicting the hydraulic failure of a rockfill core dam
Authors:   National Research University “Moscow Power Engineering Institute” (MPEI), Sainov Mikhail P. , Boldin Alexander A. ,   Moscow State University of Civil Engineering (National Research University) (MGSU)
Published: May 2023

Introduction. The phenomenon of hydraulic fracture is associated with the failure of some earth-rock dams, in which the integrity of the core made of clay soil has been compromised. It is believed that hydraulic fracture occurs when the pressure of water contained in pores and microcracks overcomes the compressive stresses in the soil. At this point, several methods have been proposed for the computational prediction of hydraulic fracture. They are aimed at determining the conditions under which hydraulic fracture occurs and at determining the critical water pressure that causes fracture growth. Materials and methods. A review of foreign scientific publications was carried out to systematise information on methods and techniques for critical pressure determination. Results. The review gives a classification of methods for predicting hydraulic fracture. Theoretical methods are based on the usage of elasticity theory, plasticity theory or fracture mechanics. The simplest method is based on the analysis of the stress state of the soil mass. This review describes methods based on the analysis of the stress-strain state of soil around a cavity with internal pressure. They consider several mechanisms of crack propagation, including the loss of tensile and shear strength. Empirical formulas based on the results of laboratory experiments are also given. In the framework of the analytical review, a comparison of some methodologies has been carried out. Most of the methodologies agree that the critical pressure primarily depends on the minimum principal stress σ3 in the ground. The comparison showed that the critical pressure calculated by the theoretical triaxial stress analysis technique is noticeably lower than that calculated by the empirical techniques. In the presence of a cavity, the more likely cause of fracturing is the loss of shear strength of the soil rather than tensile strength. Conclusions. Despite the abundance of techniques for predicting hydraulic fracturing, no theoretically verified and accurate methodology has been established at the present time.
Stress-strain state of a triangular truss with uncut chords of a five-sided composite profile
Authors:   Moscow State University of Civil Engineering (National Research University) (MGSU), Melyokhin Evgeniy A.
Published: May 2023

Introduction. The author considers designs of triangular trusses that can be used to design roofs of industrial and public buildings, various combined systems, and also as overpass structures of linear facilities. The design of a spatial truss as part of a patent pending development of a triangular truss cover with non-cutting closed-section chords is presented. The purpose of numerical studies is to estimate the stress-strain state (SSS) of a spanning triangular truss subjected to static nodal load and different arrangement of strut elements as well as to create a verification database for further numerical studies of non-faceted interface nodes. Materials and methods. The numerical research methodology takes into account the application of nodal static loads, modelling the placement of the enclosing structure of the pavement using purlins. The use of the unit load method is aimed at determining the response of the load-bearing system as part of a comparative evaluation and comparison with the data obtained from other research tasks. Results. In the course of numerical studies, data were obtained, characterising the deflected mode of the triangular truss model in terms of force distribution in the rods and vertical displacements of the nodes. Conclusions. Analysis of the obtained results shows that the accepted design model of a triangular truss adequately reflects its deflected mode. Practical application of the numerical research technique on the basis of application of unit nodal loads consists in the possibility of using calculation results in the form of a structured data set required in calculations by the limit states method. The results obtained can be used as a basis for verification of data obtained in further numerical studies of non-faceted node constructions within the framework of the lamellar mathematical model. The presented numerical studies are part of the complex of scientific research into the actual performance of spanning triangular trusses.
Formation of an organisational and technological mechanism to improve the manufacturability of works in total building renovation
Authors:   Moscow State University of Civil Engineering (National Research University) (MGSU), Petrosyan Rima S.
Published: May 2023

Introduction. Modern methods of executing total building renovation are based on the principles of flow and scientific methods of labour organisation, developed with due regard for the specific features of certain types of repair and construction works technologies. The following labour-intensiveness and duration of work, material-intensiveness, cost and production cost of constructions are considered as the main indicators of work production technology in the course of overhaul repair. Each of these indicators has corresponding reserves, which are identified and used to improve the manufacturability of production of each type of work, as well as on the building as a whole. Materials and methods. The article is based on the method of assessing the effectiveness of various options to reduce the duration of work, which directly affects the change in technological parameters. A ranking among contractors has been carried out to identify the reserves for increasing labour productivity, as well as to identify bona fide contractors for customers. Results. The developed methodology of evaluation of manufacturability of overhaul works allows contractors to justify for customers the proposals on reduction of terms and cost of overhaul works. The use of the developed organizational and technological mechanism in practice of interaction of all participants of capital repair process will allow not only to achieve the highest indicators, but also will serve as a basis for actualization of normative documents on total building renovation. Conclusions. The method of efficiency estimation of different variants of work time reduction and related changes of technological parameters according to Wald, Savage and Hurwitz criteria allowed to establish the most preferable construction-technological solution. The developed rating assessment of contractors will, on the basis of achieved results, enable to reveal reserves of increasing labour productivity in the course of repair-construction works and to encourage these organizations to be more preferable in carrying out competitive procedures of selecting contractors by the customer. The identified reserves of reducing the duration of overhaul works are used as a basis for the formation of measures to improve the manufacturability of works.
Pharmaceutical Standardization of Muktashukti Bhasma and Muktashukti Pishti
Authors: Kamble Shweta , Wanjari Anita
Published: May 2023

Shukti is an important component of Sudhavarga, the most recent class in the subject of Rasa Shastra. According to the availability, two forms of Shukti have been stated in Rasa Shastra texts: Jalashukti and Muktashukti. Muktashukti is considered for the study. This study has tried to develop the standard operating process for manufacturing Muktashukti bhasma and Muktashukti pishti. Three batches of MSB & MSP were prepared from the purified Muktashukti. While manufacturing three batches same raw material and manufacturing instruments were used. Before processing for Bhasma or Pishti, the purification process is advocated for Muktashukti. Kanji (Rice gruel) was used for purification as per textual reference. Purified Muktashukti was levigated with Rose water to obtain Pishti. However, for Bhasma preparation, the Muktashukti was triturated with Aloe vera juice, and then heating was done in an Electric muffle furnace. 7 liters of Kanji was taken for 500g of Muktashukti Shodhana by Swedana for 3hrs in Dolayantra, with an average weight rise of 96.24% and a weight loss of 3.76% during the Shodhana method. During MSB preparation, a 10% loss was observed & 90% of Bhasma was obtained. However, in MSP preparation, a 12.14% loss was observed & 87.86% was obtained. This study will give the direction related to the duration of levigation and temperature regulation while Muktashukti Bhasma preparation. For Pishti preparation, the wet grinder was used, which will provide exact rotation and duration to obtain the proper pishti from Muktashukti.
COVID-19 and Diabetes Mellitus at RSU South Tangerang-Indonesia: Clinical Profile and Treatment Strategies
Authors: Hasanah Nur , Ismaya Nurwulan Adi , Tulandi Silvester Maximus , Permatasari Putri Indah , Wafa Wafa , Hakim Amelia Nurul
Published: May 2023

Background: Diabetes Mellitus is one of the risk factors for COVID-19. This causes the morbidity and severity of COVID-19 patients to be higher in patients with diabetes. Objectivity: This study aimed to determine the effectiveness of treatment therapy for COVID-19 patients with comorbid diabetes at the South Tangerang City General Hospital. Material and methods: This study used a descriptive design with a quantitative approach and retrospective data collection. Sampling was done by Total Sampling with a total sample of 127 patients from 234 patients. Result: The characteristics of COVID-19 patients with comorbid diabetes were dominated by the male gender (55.1%), with an age range of 46-55 years (38.6%), high school education (43.3%), and have a private employee type of work (55.1%). The symptoms of COVID-19 patients with comorbid diabetes were cough (89.8%), with a length of stay for patients 7–14 days (72.4%).Treatment for COVID-19 with comorbid diabetes was antibiotics azithromycin (26.0%), antiviral remdesivir (62.2%), methylprednisolone (73.2%), acetylcysteine (85.0%), vitamin C (89.8%), and the antidiabetic group that is often used is insulin novorapid (41.7%). Conclusion: The results of laboratory examinations showed that COVID-19 treatment therapy is effective in reducing the amount of virus in the blood, which is indicated by an increase in the PCR value (p-value <0.001), lowering blood sugar levels (which is characterized by a decrease in blood sugar levels when (p-value <0.001) ), and reduce hypercoagulation which is characterized by a reduction in the value of D-dimer (p-value < 0.005).
La protección internacional en los casos de desplazamientos forzados en España
Authors: Ocampo Castaño Jenny Alexandra , Mut Montalva Elena
Published: May 2023

Colombia has extensive regulatory development on the subject of internal forced displacement, but when it comes to external or transnational forced displacement there are legal gaps and difficulties in the processes of comprehensive reparation for victims who are abroad, especially in the cases of women human rights defenders. In addition, in Colombia there is an invisibility of political exile. The objective of this research has been to know the right to international protection in cases of forced external displacement and the differential impacts that this type of violence has on the economic, social and political life of the women activists who belong to the Women’s Collective. Colombian Refugees, Exiles and Migrants in the city of Valencia Spain. The methodology of this qualitative research has been based on two main techniques. The first has consisted of documentary analysis and bibliographic review on the right to international protection in Spain and the normative development of forced displacement in the Colombian legal system from the perspective of gender in law. The second technique has consisted of carrying out semi-structured interviews with the members of the Collective of Colombian Refugee, Exiled and Migrant Women in the city of Valencia, Spain. As a result, it has become evident that there are gaps in public policies and international protection policies in Spain and Colombia to address cases of forced displacement abroad. In turn, these legal gaps come from international human rights law itself, because it has developed a concept of refuge, asylum and subsidiary protection with an androcentric approach.
Resolución pacífica de conflictos en la escuela
Authors: Godoy Usuga Adriana Patricia
Published: May 2023

This article takes a tour by the different aspects of school conflict identified in the development of the Program for School Coexistence - Hermes of the Bogotá Chamber of Commerce, in a school in the official sector of the city. Believe that educommunication is creative alternatives are presented for the peaceful resolution of conflicts at school, from the theoretical perspective of Communication for Social and Behavioral Change. Starts question about ¿How do educommunication actions helped to the peaceful resolution of conflicts in Isla del Sol school – cycle V? According to systematization of experiences Hermes Program propose it educommunication actions in favor the peaceful conflict resolution in youth school context.
BRAIN TUMOR SEGMENTATION ON FLAIR MR IMAGES WITH U-NET
Authors: GÜVENÇ Ercüment , ERSOY Mevlüt , ÇETİN Gürcan
Published: May 2023

Brain tumors are among the illnesses that, if not treated promptly, can lead to death. It is extremely difficult to detect tumor tissue using only eye examination methods. As a result, Magnetic Resonance (MR) imaging is used to diagnose brain tumors. T1, T1c, T2, and FLAIR MRI sequences provide detailed information about brain tumors. If the segmentation procedure is performed correctly, patients' chances of survival improve. This paper describes an automated brain tumor segmentation for FLAIR sequences in MR images using U-NeT method. The study has been carried out on the BraTS 2018 data set. The models' correctness has been assessed using the binary accuracy, dice coefficient, and IOU assessment criteria. The results of the comparison between the tumor regions identified by the expert physicians and the tumor regions calculated by the U-Net model are as follows: The model has been completed with 99.26% accuracy, and the dice coefficient value, which expresses the similarity on the basis of pixels for the test data, has been found to be 73.99%. Furthermore, the IOU value of 0.59 demonstrated that the model provided accurate estimates for the study.
Bioequivalence Study Followed by Model Informed Dose Optimization of a Powder for Oral Suspension of 6-Mercaptopurine
Authors: A Bhavatharini P , Joshi Mahendra , Kakkar Archana , Madki Shivkumar , Ivaturi Vijay , Chinnaswamy Girish , Banavali Shripad , Gota Vikram
Published: May 2023

AIMS 6 mercaptopurine (6MP) is the mainstay chemotherapy for acute
lymphoblastic leukaemia (ALL) and is conventionally available as 50 mg
tablets. This study aimed to evaluate the bioequivalence of a new 6MP
Powder for Oral Suspension (PFOS) intended for paediatric use.
Additionally, a virtual study with the obtained data was planned for
determining a dose of the PFOS that matches tablet exposures and to
confirm optimal drug levels in pediatrics. METHODS An open-label,
randomized, two-treatment, two-period, two-sequence, single oral dose,
crossover, bioequivalence study was conducted on 51 healthy subjects. A
population pharmacokinetic (PopPK) model was developed using the data to
perform simulations with various PFOS doses and select a bioequivalent
dose. To simulate 6MP and 6 thioguanine (6TGN) exposures in pediatrics,
a literature model for paediatric ALL patients, and allometrically
scaled PK parameters were utilised. RESULTS The 6MP PFOS had 47% higher
bioavailability compared to the reference product. Simulations using a
two-compartmental PopPK model with dissolution and transit compartments
showed that 40 mg of PFOS was found to be equivalent to the 50mg
tablets. The simulated 6TGN concentrations in virtual paediatric
patients were between 114 and 703.6 pmol/8x108 RBCs, which was within
the range of values reported in paediatric ALL studies. CONCLUSION The
study demonstrates that 40 mg dose of 6MP PFOS 10 mg/mL has the same
extent of absorption as the 50 mg tablet which can be precisely
administered in pediatrics. The study also demonstrates the role of
modelling and simulation to perform virtual bioequivalence and
paediatric studies.
Influence of Xanthomonas euvesicatoria on quality parameters of pepper seed from Serbia
Authors: Zivkovic Ivana , Ilicic Renata , Barac Goran , Damnjanovic Jelena , Cvikic Dejan , Trkulja Nenad , Popovic-Milovanovic Tatjana
Published: May 2023

The present study focused on detecting bacteria of the Xanthomonas spp.
complex (X. euvesicatoria, X. vesicatoria, X. perforans and X. gardneri) and
examining their influence on certain quality parameters of pepper seed
collected from the territory of Smederevska Palanka (Serbia). The analysis
included 27 non-commercial pepper seed genotypes (including chili and sweet
pepper) collected in 2021. Several parameters of the quality of analyzed
pepper seed (germination energy, total germination, moisture and seed
health) were determined. The results showed that out of a total of 27
analyzed samples of pepper seed, the presence of X. euvesicatoria was
detected in 13 of them. The presence of X. vesicatoria, X. gardneri and X.
perforans was not confirmed. Germination energy of infected seed was 52-84%,
and of bacteria-free seed 63-90%; total germination of infected seed was
66-91%, and of bacteria-free seed 80-95%. Seed moisture of infected seed
samples was 6.1-12%, and of bacteria-free seed 6.2-8.1%. These parameters
did not show significant statistical difference (p>0.05). The presence of
seed-borne fungi Fusarium sp. accounted for up to 3% in 25 samples, while it
was up to 6% in the remaining two; Alternaria sp. ranked from 1-4% in 25
samples, and up to 5% in only two samples. The results led to a conclusion
that the bacterium X. euvesicatoria is the predominant pathogen of the
Xanthomonas spp. complex, but it did not affect the quality parameters of
the tested pepper seed.
A Catalyst Free Surfactant Mediated Multicomponent Synthesis of Quinazolinone Derivatives in Aqueous Media
Authors: Kumar Pratyoosh , Amber Nausheen , Tripathi Vishwa Deepak
Published: May 2023

A versatile and green synthetic protocol has been developed for synthesis of substituted quinazolinone and spiroquinazolinone heterocycles effectively via a combined surfactant mediated system. The use of Surfactant, water as reaction medium, room temperature, high yield and ease of purification made the process very effective and ecofriendly in nature. To demonstrate the wide scope of reaction Isatoic anhydride and Isatin used as reactants in different sets of reactions that leads to formation of Quinazolinones and spiroquinazolinones. A total of 12 derivatives has been prepared and characterized by all the spectroscopic data. The developed protocol presents a better and environmentally efficient methodology to get these heterocycles.
Investigation of the changes in physical and chemical parameters of Damascus goat milk in the early postpartum
Authors: Gocmen Huban , Darbaz Isfendiyar , Ergene Osman , Aslan Selim
Published: May 2023

The aim of this study was to reveal the milk components and the changes in their characteristics in Damascus goats during the early postpartum period. For this purpose, 50 Damascus goats (aged 2 to 8 years) were selected for this study. A total of 291 milk samples were collected under sterile conditions during the mornings of the 10th, 20th and 30th days postpartum. Results were statistically analysed using the Mann-Whitney U Test and repeated measures ANOVA. All collected samples were analysed for milk composition (lactose (L), protein (P), casein (C), fat (F), total solid (TS), solid not fat (SNF), freezing point (FP), acidity (A), density (D), free fatty acid (FFA), and citric acid (CA)). A significant decrease was detected in P, C, F, TS and SNF values between the 10th and 30th days postpartum (pp) (P <0.01). Similar results were also observed in FP, A, D and CA values between the same days (P <0.05; P <0.01). A significant positive correlation was detected between FP, A, P, C, F and TS (0.812 and 0.980; P<0.05 and P<0.01). Additionally, a correlation was detected between C and P (0.983; P <0.01). These results reveal that these parameters decreased significantly in the early puerperal period compared to the first 10 days, and these decreases were not associated with an increase during milk yield in the early period of lactation (up to the 30th-day pp).
PENAFSIRAN AYAT TENTANG SHALAT TAHAJUD DAN HUBUNGANNYA DENGAN KESEHATAN MENTAL (Interpretasi Ma’na-Cum-Maghza Terhadap Q.S. Al-Isra’ [17]: 79)
Authors: . Muhafizah
Published: May 2023

Abstract
This article describes the interpretation of Q.S. Al-Isra '[17]: 79 which is the basis for the command to perform the tahajjud prayer. Including when the Prophet was faced with a big problem, then the Surah Al-Isra 'verse [17]: 79 was revealed as a solution to the problems faced and is a form of help from Allah SWT. Thus, the author wants to examine this theme further by using qualitative research methods (library research) and the Ma'na-Cum-Maghza Interpretation approach. The conclusion of this article is that there are several interpretations of the main message from Surah Al-Isra 'verse [17]: 79, including as a help and solution to solve all life problems related to spirituality. So that by performing the tahajjud prayer, you will get closer to Allah SWT. Then at night, which makes the Tahajjud prayer different, so that the level of solemnity is higher than prayer in general, it will be more peaceful and calm in praying, the heart becomes peaceful. When the heart is peaceful and the mind is clear, it is easy to think of solutions to solve all the problems that are being.
ALTRUISME (AL-ISAR) DALAM PERSPEKTIF AL-QUR’AN
Authors: Fatimah Siti
Published: May 2023

Abstract
This article discusses about a term that is called by altruism. Altruism is a willingness to do something that bring advantages to others sincerely. In the Quran surah al-Hasr verse: 9, this term is known as al-Isar. The Existence of altruism or al-Isar in social life is very important and necessary. It is because people are social beings that always need the presence of other people in their daily life. The method of this research is library research and thematic vocabulary. It is concluded that altruism is phenomenal social events in Islam because it is a behaviour that puts others first even though he is in troubles. Altruism has no limit generally, so that it becomes top of brotherhood.
EPISTEMOLOGI PEMIKIRAN ANDREW RIPPIN DAN IMPLIKASINYA TERHADAP FUNGSI ASBABUN NUZUL (Analisis Atas Artikel The Function of Asbab An-Nuzul in Qur'anic Exegesis)
Authors: Ghozali Ahmad , Noor Muhammad Azka
Published: May 2023

This article discusses the epistemology of Andrew Rippin's thought which is considered different from that of his teacher John Wansbrough. The sources of knowledge used by Rippin come from John Wansbrough, as-Suyuti, al-Wahidi, Ibn As'ad, al-'Iraki, and books at the Staatsbibliothek, Berlin. The method or approach he uses is a historical or historical horizon and literary analysis. Validity Truth is based on coherence theory, correspondence theory, and pragmatism theory. This study also shows the implications of Rippin's thoughts on the function of Asbab an-Nuzul. First, many Muslim scholars have written about Asbab an-Nuzul, but it is only a quote and then left alone. The second is a recommendation to the scholars of the Koran to reconsider the construction of Asbab an-Nuzul in its interpretation. This study is a literature review with a descriptive-analytic method of exposure to Rippin's article entitled The Function of Asbab an-Nuzul in Qur'anic Exegesis as primary data and other books as secondary data.
Artikel ini membahas tentang epistemologi pemikiran Andrew Rippin yang dianggap berbeda dengan pemikiran gurunya John Wansbrough. Sumber-Sumber Pengetahuan yang digunakan Rippin bersumber dari John Wansbrough, as-Suyuti, al-Wahidi, Ibnu As’ad, al-‘Iraki, dan buku di Staatsbibliothek, Berlin. Metode atau pendekatan yang digunakannya adalah horizon historis atau sejarah dan analisis sastra. Validitas Kebenaran berdasarkan teori koherensi, teori korespodensi, teori pragmatism. Serta kajian ini juga memperlihatkan implikasi pemikiran Rippin terhadap fungsi Asbab an-Nuzul. Pertama, sarjana muslim banyak yang menulis tentang Asbab an-Nuzul namun hanya sebatas kutipan kemudian dibiarkan. Kedua menjadi rekomendasi kepada kesarjanaan Quran mempertimbangkan kembali kontruksi asbab an-nuzul dalam penafsirannya. Kajian ini merupakan kajian pustaka dengan metode pemaparan deskriptif-analitis terhadap artikelnya Rippin yang berjudul The Function of Asbab an-Nuzul in Qur'anic Exegesis sebagai data primer dan buku-buku lainnya sebagai data sekunder.
DESIGNING A TECHNOLOGY VALUATION MODEL IN IRANIAN STARTUPS
Authors:   Islamic Azad University, Tehran, Iran, GOLSHANI Ali , ADAB Hossein ,   Islamic Azad University, Tehran, Iran, SARABADANI Abolghasem ,   Tarbiat Modares University, Tehran, Iran, SHAFAGHI Masoud ,   International Federation of Inventors' Associations, Geneva, Switzerland
Published: May 2023

Technology valuation is needed by companies in today's knowledge-based economy. The intangible nature of technology, influence of environmental factors and conditions on it, have made calculating its value complicated. At present, a large part of the country's economic activities in the technological ecosystem is carried out by companies and startups, whose growth and development are possible with the influx of capital. Therefore, the aim of the upcoming research was to identify dimensions and explain the technology valuation model in Iranian startups. The approach of the research is qualitative, and in the research process, the Grounded Theory has been used. The 10 participants including active experts, policymakers, consultants, and CEOs in Iran's startup ecosystem, were selected by using the purposeful sampling method and analyzed by using the content analysis method. Participants identified factors such as lack of technology valuation requirements, bubble of startups claiming technology, innovation as causal factors, technology brokers and conflict of interests as interfering factors in the strategies of the desired phenomenon, development and promotion of technology valuation discourse, transformation of existing knowledge in the field of technology to valuable knowledge, leadership and idea management and localization of technology valuation as solution-oriented strategies, benefits of calculating the real value of technology and valuation process itself regardless of the result were expressed as the consequences of expanding the technology valuation model in Iranian startups. In this way, the dimensions of the desired model were extracted and explained.
ADAPTATION STRATEGIES AMONG PETTY TRADERS IN SECURING LIVELIHOODS DURING COVID-19 HIGH TENSION PERIOD IN UBUNGO MUNICIPALITY, TANZANIA
Authors:   Mwalimu Nyerere Memorial Academy, Dar es Salaam, Tanzania, KALINGA Atupakisye
Published: May 2023

The Covid-19 was declared a pandemic by World Health Organization on March, 2020 a situation that drew attention among the world communities. In Tanzania the first case was reported on 16th March, 2020 in Arusha Region and few weeks later other cases were reported in other regions which made the whole country to be devastated. Following the declaration of Covid-19 in Tanzania different social services were closed that led to a decline in demand of various commodities. This situation threatened the livelihoods of various individuals and groups of people including petty traders. This paper assessed adaptation strategies among petty traders in securing livelihoods at the midst of Covid 19 with the case of Ubungo Municipality, Tanzania. Data were collected through questionnaire, focused group discussion (FGDs), key informant interviews (KIIs) and field observation. SPSS and Microsoft Excel were used to analyse quantitative data while qualitative data was analysis by content analyse. The findings reveals that selling newly demanded Covid 19 safety and hygienic commodities alongside common consumer goods was one of the most important adaptation strategies among petty traders in Ubungo Municipality. Further, the findings reveals that petty traders faced a number of challenges including health risks, financial problem, decline of customers and drastic fall of prices which threatened the profitability of their business. It is recommended that further scientific studies be directed towards solving constraints faced and investigating the opportunities of Covid-19 pandemic to be utilised for resilient business and sustained livelihoods.
APPLICATION AND IMPLEMENTATION OF TQM WITHIN THE FEDERAL AUTHORITY FOR IDENTITY (ICP) - UAE
Authors:   Hamdan Bin Mohamad Smart University, Dubai, UAE, ALKHAFILI Maitha Abdul Wahid , ALAWADHI Afraa Mohammad ,   Hamdan Bin Mohamad Smart University, Dubai, UAE
Published: May 2023

Total quality management specifically the business excellence models have been adopted and accepted worldwide in many different organizations, Likewise, these models’ popularity and acceptance are continuously increasing in UAE and Gulf as well. This study aimed to analyze the quality and business excellence models adopted by the Federal Authority for Identity, Citizenship, and Customs & Port Security (ICP), which is an organization in the public sector and has actively implemented TQM and an excellence model since 2004. The study identified the success, implementation, and possible flaws present in the implementation of the model. This study design was qualitative, based on Semi-structured interviews. A total of 20 interview participants were selected and their interviews were conducted within a month and a half. The results of the interviews showed that the organization faced many challenges and issues in the execution of the business excellence model. Moreover, with proper coordination, Communication, and strategies, they successfully adopted the model and the effort has led to the winning of 70 local and international awards. Business excellence approaches of total quality management are very difficult to implement and frequently result in organizational failure. TQM is complex to incorporate into organizational structures; instead, it may require cultural stimulation, significant change, task rearrangement, managerial responsibility clarification, employee growth, and alignment with an organizational business plan.
Two Spectrophotometric Methods Based on Diazotization Coupling Reaction for Determination of Genistein in Pure and Supplement
Authors: Mohammed Farqid F. , Abed Sadeem Subhi
Published: May 2023

Genistein (GEN) is one of the predominant dietary isoflavones found in legumes such as soybeans. Genistein has been recommended as an osteoporosis treatment for postmenopausal women and elderly men, with the intention of reducing cardiovascular disease and hormone-dependent malignancies. Therefore, two sensitive and simple methods for quantifying it in the supplements preparation were developed.The first method (A) comprised employing the surfactant Triton X-114 to extract the result of the diazotization reaction with 4-Aminoacetophenone(4AMA) utilizing a cloud point extraction technique. The product was extracted using micelles of a non-ionic surfactant (TritonX-114) and then spectrophotometrically detected at a specified wavelength of 437nm. The linearity of the calibration curve was in the range of 0.25 -2.75 µg/mL of GEN(r = 0.9978) under optimal conditions. The average sample recovery was determined to be between 96 and 101 %. For 2 µg/mL of GEN, the relative standard deviation (RSD) was (0.27%). The second method (B) involved using the spectrophotometric-flow injection methodology for the same diazotization coupling reaction described above, and  the orange colored dyewas measured at a   wave length of 437 nm.Calibration curve were linear at different concentration range of GEN 10 to 100 µg/mL , relative standard deviation RSD% were 0.23 to 1.21. The proposed methods were applied to determine the presence of GEN in Supplements.