bluuebunny/crossref_metadata_2025 huggingface dataset:
Scrolling for fun or to cope? Associations between social media motives and social media disorder symptoms in adolescents and young adults
Authors: Thorell Lisa B. , Autenrieth Milena , Riccardi Alice , Burén Jonas , Nutley Sissela B.
Published: August 2024

Introduction

Although not yet recognized as an official disorder, Social Media Disorder (SMD) has recently received considerable interest in the research. However, relatively little is known about underlying motives for social media use and to what extent motives show differential associations with SMD symptom severity and SMD diagnosis. The overall aim of the present study was therefore to examine motives for social media use in relation to (1) which motives are most common, (2) associations between motives and both SMD symptom severity and SMD diagnosis, and (3) the effects of sex and age.

Methods

Data were collected through a digital survey (n = 1820) and included both high school students (n = 924) and university students (n = 896). Six different motives were assessed, and SMD was measured in relation to both Heavy Involvement and Negative Consequences of social media use.

Results

The results showed that the most common social media use motives were Entertainment, Social Maintenance, and Information and Skills. However, it was the three least common motives – Social Compensation, Self-status, and Escape – that were most strongly associated with SMD symptom severity and SMD diagnosis. These three motives explained as much as 42% of the variance in negative consequences of social media use. Only a few small effects of sex or age were found.

Discussion

Some social media use motives are much more strongly associated with SMD than others are. This could indicate that prevention and intervention programs should target these motives specifically, rather than focusing on social media use in general.
Development of a structured interview for the modified version of the Beth Israel Hospital psychosomatic questionnaire for alexithymia
Authors: Komaki Gen , Baba Takanobu , Yoshida Toshiyuki , Arimura Tatsuyuki , Moriguchi Yoshiya , Maeda Motonari
Published: August 2024

Background

An observer-rated questionnaire for alexithymia based on the original 17-item Beth Israel Hospital Psychosomatic Questionnaire for Alexithymia (BIQ) was developed by Sifneos in 1973 and modified into a 12-item version of BIQ by Taylor et al. in 1997. However, it has rarely been used in a clinical or research context and studies have not given satisfactory inter-rater reliability for the 12-item version.

Objective

To develop a structured interview in Japanese for the12-item modified version of BIQ (m-SIBIQ) to determine the reliability and validity of the m- scores and its factor structure model.

Methods

Ninety-two Japanese young adults were interviewed. The inter-rater reliability of the m-SIBIQ was assessed by exploratory factor analysis. For the concurrent and convergent validities, correlation analysis was done between the scores of m-SIBIQ and the self-reported questionnaires: 20-Item Toronto Alexithymia Scale (TAS-20), NEO Five-Factor Inventory (NEO-FFI), Emotional Empathy Scale (EES), Interpersonal Reactivity Index (IRI), Beck Depression Inventory-II (BDI-II), and State-Trait Anxiety Inventory (STAI). Goodness of fit of the structure model of the m-SIBIQ was evaluated using confirmatory factor analysis, and the results were examined through stepwise multiple regression analysis.

Results

Good reliability was obtained for the total score of m-SIBIQ: Cronbach’s α.950 (p<.001) and ICC.75(p<.05). The validity of the factor structure was obtained by confirmatory factor analysis using covariance. The model of the alexithymia constructs was configured by the operative thinking (la pensée opératoire) and affect awareness components. The stepwise multiple regression analysis extracted the total score of m-SIBIQ as significantly, negatively correlated with the Openness to experience score of NEO-FFI and significantly, positively correlated with the emotionally chilly score of EES and the score of difficulty describing feelings (DDF) of TAS-20. There were no correlations between the m-SIBIQ and BDI-II scores.

Conclusion

For Japanese young adults, the m-SIBIQ is a reliable and valid instrument for overcoming weaknesses of the self-reported procedures by bringing to light the alexithymia construct and principal dimensions.
The adult ADHD assessment quality assurance standard
Authors: Adamou Marios , Arif Muhammad , Asherson Philip , Cubbin Sally , Leaver Laurence , Sedgwick-Müller Jane , Müller-Sedgwick Ulrich , van Rensburg Kobus , Kustow James
Published: August 2024

Background

Attention Deficit Hyperactivity Disorder (ADHD) frequently persists into adulthood. There are practice guidelines that outline the requirements for the assessment and treatment of adults. Nevertheless, guidelines specifying what constitutes a good quality diagnostic assessment and report and the competencies required to be a specialist assessor are lacking. This can lead to variation in the quality and reliability of adult ADHD assessments. Poor quality assessments may not be accepted as valid indicators of the presence of ADHD by other clinicians or services, resulting in wasteful re-assessments and delays in providing treatment. To address this issue the UK Adult ADHD Network (UKAAN) proposes a quality framework for adult ADHD assessments - the Adult ADHD Assessment Quality Assurance Standard (AQAS).

Methods

The co-authors agreed on five questions or themes that then guided the development of a set of consensus statements. An initial draft was reviewed and amended in an iterative process to reach a final consensus.

Results

What constitutes a high-quality diagnostic assessment and report was agreed by consensus of the co-authors. The resulting guideline emphasises the need to evaluate impairment, describes core competencies required by the assessor and highlights the importance of linking the diagnosis to an appropriate post-diagnostic discussion. Assessments should be completed in the context of a full psychiatric and neurodevelopmental review, and need good interview skills, using a semi-structured interview with open questioning and probing to elicit real life examples of symptoms and impairments. It is recommended that 2 hours or more is required for an adequate assessment including both the diagnostic assessment and initial post-assessment discussions.

Conclusion

The AQAS has been developed as a practical resource to support reliable and valid diagnostic assessments of adult ADHD. It is intended to complement formal training. A secondary objective is to empower patients by providing them with evidence-based information on what to expect from an assessment and assessment report.
Study on the effectiveness of a community hypertension management model based on home smart blood pressure monitoring using IoT technology
Authors: Li Cheng , Fan Shuhao , Li Hui
Published: August 2024

Background

Hypertension is rapidly increasing in China, but control rates are significantly low. There is a pressing need for effective management models in primary community health settings.

Methods

In April 2023, 459 patients from six communities in Jinan City were enrolled using a multi-stage random sampling method and assigned to either a control group comprising 243 participants or an intervention group comprising 216 participants. The control group received standard hypertension care, whereas the intervention group participated in a novel IoT-based remote blood pressure monitoring program for 6 months. Data collection was conducted through detailed questionnaire surveys, cloud platform records, and community management records, both before and after the intervention period. The study employed difference-in-differences (DID) and mediation effect models to assess the effects of the IoT-based management model.

Results

The DID model demonstrated that the intervention significantly reduced systolic blood pressure by 9.883 mm Hg and diastolic blood pressure by 6.553 mm Hg. The mediation effect model showed that the frequency of blood pressure measurement and attitudes and beliefs toward hypertension treatment had mediating effects, accounting for 5.82 and 8.07% of the total effect, respectively. The heterogeneity analysis revealed significant regional differences: rural residents experienced a greater decrease in systolic and diastolic blood pressures by 14.85 mm Hg and 6.591 mm Hg, respectively, compared to urban residents, whose diastolic pressure decreased by 6.046 mm Hg.

Recommendations

It is advisable to develop differentiated hypertension management strategies tailored to specific regional needs to promote the deep integration and widespread application of smart blood pressure monitoring technology. Enhancing patient awareness and capabilities in managing their health condition is crucial for improving the blood pressure control level among community hypertension patients.
Small Amazonian stingless bees: an opportunity for targeted cocoa pollination
Authors: Maia-Silva Camila , Hrncir Michael , Giannini Tereza Cristina , Toledo-Hernández Manuel , Imperatriz-Fonseca Vera L.
Published: August 2024

Cocoa (Theobroma cacao) is a multi-billion-dollar business. This tropical crop strongly depends on animal pollination for fruit development and seed production. The lack or inefficiency of natural pollinators in cocoa plantations has driven farmers to search for alternatives, such as laborious pollination by hand. A so far untested alternative, which has received increasing attention during the past couple of years, is targeted crop pollination through managed social bees. However, owing to the smallness of the flowers of T. cacao as well as structural barriers that impede large insects to access the stigma, only tiny bees may be a viable option for targeted cocoa pollination. In the present study, we asked whether small stingless bees (Apidae, Meliponini) could come into consideration as managed cocoa crop-pollinators, especially in shadowy agroforests. Among the 188 meliponine species native to the Brazilian Amazon region, which comprises an important portion of the center of origin of T. cacao, we selected 52 species based on morphological criteria (intertegular distance ≤ 1.4 mm; body length: 2.2–6.0 mm). Important for cocoa production, some of these Meliponini have an ample geographic distribution, occurring both in the center of origin of T. cacao and beyond (centers of cocoa production in Brazil: Pará: 35 spp., Bahia: 10 spp.). Presumably all species may be active at illuminance levels below those found in heavily shaded cocoa plantations, at least at times when anthers show full dehiscence and during maximum receptivity of the stigma. The bees’ potential to forage under reduced light regimes is corroborated by the finding that between 20 and 60% of the naturally exploited food sources are understory vegetation, including herbs, subshrubs, shrubs, and lianas. Many of the selected Meliponini build their nests, at least facultatively, in tree cavities, which facilitates their transfer to rational hives and, hence, the use of managed colonies in directed crop pollination. Important next steps for validating the potential of these small stingless bees in targeted cocoa pollination should comprise detailed studies on their foraging behavior and olfactory learning capacities.
Composable and executable scenarios for simulation-based testing of mobile robots
Authors: Ortega Argentina , Parra Samuel , Schneider Sven , Hochgeschwender Nico
Published: August 2024

Few mobile robot developers already test their software on simulated robots in virtual environments or sceneries. However, the majority still shy away from simulation-based test campaigns because it remains challenging to specify and execute suitable testing scenarios, that is, models of the environment and the robots’ tasks. Through developer interviews, we identified that managing the enormous variability of testing scenarios is a major barrier to the application of simulation-based testing in robotics. Furthermore, traditional CAD or 3D-modelling tools such as SolidWorks, 3ds Max, or Blender are not suitable for specifying sceneries that vary significantly and serve different testing objectives. For some testing campaigns, it is required that the scenery replicates the dynamic (e.g., opening doors) and static features of real-world environments, whereas for others, simplified scenery is sufficient. Similarly, the task and mission specifications used for simulation-based testing range from simple point-to-point navigation tasks to more elaborate tasks that require advanced deliberation and decision-making. We propose the concept of composable and executable scenarios and associated tooling to support developers in specifying, reusing, and executing scenarios for the simulation-based testing of robotic systems. Our approach differs from traditional approaches in that it offers a means of creating scenarios that allow the addition of new semantics (e.g., dynamic elements such as doors or varying task specifications) to existing models without altering them. Thus, we can systematically construct richer scenarios that remain manageable. We evaluated our approach in a small simulation-based testing campaign, with scenarios defined around the navigation stack of a mobile robot. The scenarios gradually increased in complexity, composing new features into the scenery of previous scenarios. Our evaluation demonstrated how our approach can facilitate the reuse of models and revealed the presence of errors in the configuration of the publicly available navigation stack of our SUT, which had gone unnoticed despite its frequent use.
Complete Subhedge Projection for Stepwise Hedge Automata
Authors: Al Serhali Antonio , Niehren Joachim
Published: August 2024

We demonstrate how to evaluate stepwise hedge automata (Shas) with subhedge projection while completely projecting irrelevant subhedges. Since this requires passing finite state information top-down, we introduce the notion of downward stepwise hedge automata. We use them to define in-memory and streaming evaluators with complete subhedge projection for Shas. We then tune the evaluators so that they can decide on membership at the earliest time point. We apply our algorithms to the problem of answering regular XPath queries on Xml streams. Our experiments show that complete subhedge projection of Shas can indeed speed up earliest query answering on Xml streams so that it becomes competitive with the best existing streaming tools for XPath queries.
Transcriptome Analysis of Ganoderma lingzhi Liquid Fermentation Process Using Corn Straw as Matrix
Authors: Wang Sheng , Li Jintao , Fan Qi , Wang Shufang , Sun Changwei , Yan Meixia
Published: August 2024

Ganoderma lingzhi, a species of white rot fungus, possesses the highest abundance of lignocellulose-degrading enzymes among these fungi, as well as a relatively high carbon conversion rate. Corn straw, as an important sustainable resource, is used as a substrate for the liquid culture of G. lingzhi. However, little is known about the genes encoding the lignocellulose degradation and polysaccharide and triterpenoid biosynthetic pathways involved in this process. This paper employs transcriptomics to uncover the key genes involved in lignocellulose degradation and the synthesis of polysaccharides and triterpenoids during the liquid fermentation of G. lingzhi using corn straw as the substrate, as well as their associations. Carbohydrate-Active enzymes analysis of differential genes in the sequencing results was used to analyze the genes related to lignocellulose degradation. Among these, 43 core genes encoding CAZymes were obtained after 0 to 5 days of fermentation, and 25 core genes encoding CAZymes were obtained after 5 to 12 days of fermentation. The differential expression levels of DN3690_c0_g1 (EGL), DN3627_c0_g2 (XYN), DN4778_c0_g1 (XYN), DN2037_c0_g1 (LACC), and DN277_c2_g1 (MnP) were used to identify the key genes. The polysaccharide synthesis metabolic pathway favored mannitol synthesis, and the expression of triterpene precursor-metabolizing enzyme genes revealed higher expression levels of key enzyme genes such as ACAT, HMGS, and MPK. A correlation clustering analysis of genes related to lignocellulose degradation, polysaccharide, and triterpene anabolism during liquid fermentation showed that lignocellulose degradation genes mainly influenced arabinose and mannitol anabolism, as well as the synthesis of triterpene precursors.
Quality and Testing of Red Pepper Soft Picking Manipulator Based on RD-DEM Coupling
Authors: Zhao Hanqi , Wang Jian , Liu Yang , Chen Zhifan , Wang Jingqi , Chen Lin
Published: August 2024

Due to a shortage of labor, the harvesting of fruits and vegetables faces significant challenges. Soft robotic hands, adaptable to variable environments due to their high-curvature bending and twisting, have garnered widespread attention and usage. However, their application in Sichuan pepper picking remains largely unexplored. Therefore, this study proposes a picking soft robotic hand composed of a rigid skeleton and flexible skin for pepper harvesting. Through analyzing the characteristics of peppers, the structure of the robotic hand is determined. Inflatable airbags are employed to drive finger bending, utilizing a rotating–twisting method for Sichuan pepper picking. Structural parameters influencing the bending angle of the airbags were determined through theoretical analysis and validated via simulation. Optimal parameter combinations for the airbags were obtained through response surface experiments to establish the robotic hand model. To assess the feasibility of the robotic hand’s movement, dynamic simulations were conducted using R D (RecurDyn V9R2) software. Subsequently, a discrete element model of Sichuan pepper clusters was established and coupled with the simulation of the Sichuan pepper picking process. The results indicate that the robotic hand does not cause damage to the Sichuan peppers during picking. Finally, field tests were conducted in pepper orchards to validate the success rate of the robotic hand in picking, yielding an 85% success rate and a 0.3% damage rate.
Geospatial Approach to Determine Nitrate Values in Banana Plantations
Authors: Zamora-Espinoza Angélica , Chin Juan , Quesada-Román Adolfo , Obando Veda
Published: August 2024

Banana (Musa sp.) is one of the world’s most planted and consumed crops. Analysis of plantations using a geospatial perspective is growing in Costa Rica, and it can be used to optimize environmental analysis. The aim of this study was to propose a methodology to identify areas prone to water accumulation to quantify nitrate concentrations using geospatial modeling techniques in a 40 ha section of a banana plantation located in Siquirres, Limón, Costa Rica. A total of five geomorphometric variables (Slope, Slope Length factor (LS factor), Terrain Ruggedness Index (TRI), Topographic Wetness Index (TWI), and Flow Accumulation) were selected in the geospatial model. A 9 cm resolution digital elevation model (DEM) derived from unmanned aerial vehicles (UAVs) was employed to calculate geomorphometric variables. ArcGIS 10.6 and SAGA GIS 7.8.2 software were used in the data integration and analysis. The results showed that Slope and Topographic Wetness Index (TWI) are the geomorphometric parameters that better explained the areas prone to water accumulation and indicated which drainage channels are proper areas to sample nitrate values. The average nitrate concentration in high-probability areas was 8.73 ± 1.53 mg/L, while in low-probability areas, it was 11.28 ± 2.49 mg/L. Despite these differences, statistical analysis revealed no significant difference in nitrate concentrations between high- and low-probability areas. The method proposed here allows us to obtain reliable results in banana fields worldwide.
Photosynthetic and Physiological Responses of Different Maize Varieties to Mesotrione
Authors: Sun Shufeng , Wang Liru , Wang Shuang , Yu Na , Zhong Xuemei
Published: August 2024

Mesotrione (MET) belongs to the p-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting class of maize post-emergence herbicides, and it is safe for maize at the recommended doses, but the safety of MET differs among maize varieties in actual field production. In this study, four different maize varieties, ZD958, SN3, ST6 and POP16, were used as experimental materials to analyze their physiological responses to MET by comparing the activities of photosynthesis and antioxidant enzymes as well as the HPPD activity. The results showed that ZD958 was the most resistant to MET, followed by SN3 and ST6, and POP16 was the most sensitive to MET. The primary photosynthetic and antioxidant enzyme indices of all four maize varieties indicated that the resistant variety ZD958 was significantly higher than the sensitive variety POP16. HPPD activity was highest in ZD958 followed by SN3 and ST6 in both treated and control groups. POP16 exhibited the lowest HPPD activity. The results showed that the differences in resistance to MET in different types of maize varieties were closely related to the photosynthetic efficiency of plants and the HPPD activity. MET had minimal impact on common maize but showed a significant effect on popcorn.
Research and Experiment on the Ditching Performance of a Ditching and Film-Covering Machine in the Yellow Sand Cultivation Mode of Solar Greenhouses
Authors: Song Yalong , Xu Jiahui , Xing Jianfei , Wang Xufeng , Hu Can , Wang Long , Li Wentao
Published: August 2024

This research initiative, developed in response to the need for enhanced mechanization efficiency within solar greenhouses, particularly under yellow sand cultivation conditions, introduces an integrated ditching and film-covering machine. A novel spiral staggered throw-cut combined ditching knife was specifically engineered and optimized to meet the exacting agronomic requirements of embedded substrate cultivation. Extensive analyses of soil interactions and the formulation of dynamic equations for soil particles facilitated the determination of key operational parameters: a tangent height of 650 mm for the ditching knife, a soil-throwing width of 300 mm, a piece width of 120 mm, and an inclination angle of 30°. Performance simulations of the ditching knife, conducted using the discrete element method (DEM), revealed superior soil disturbance control and improved soil return compared to conventional designs. Critical operational variables such as forward speed, knife shaft speed, and ditching depth were rigorously tested, with trench depth quality and power consumption as primary evaluation metrics. The results demonstrated that knife shaft speed profoundly influences performance, with optimal operating parameters established through detailed field testing: a speed of 0.5 m/s, a blade shaft speed of 200 rpm, and a ditching depth of 300 mm. Under these optimized conditions, the machine achieved power consumption of 0.668 kW, trench depth stability of 86.7%, a surface width of 413 mm, a bottom width of 304 mm, and an average ditching depth of 310 mm, achieving a qualification rate of 87.1%. The post-ditching soil crushing rate was 92.4%. Both simulation and field evaluations validated that the innovative ditching knife markedly enhances ditching and soil-throwing quality in sandy soil, fulfills agronomic requirements for tomato sowing, and provides an essential reference for the mechanized planting of crops in the yellow sand matrix cultivation mode of solar greenhouses.
A Dynamic Tool to Describe Lamb Growth and Its Use as a Decision Support System
Authors: Amaral Rafael Marzall , Rodrigues Marcelo Teixeira , Schultz Erica Beatriz , Reis Cristiano Eduardo Rodrigues
Published: August 2024

A dynamic model has been developed to simulate aspects of feedlot lamb growth and body composition, including energy and protein requirements, growth rate, composition of gain, and body mass. Model inputs include initial body mass (kg), standard final mass (kg), age (days), and dietary energy concentration (Mcal·kg−1). The model was assessed as a decision support tool using a dataset of 564 individual measures of final body mass and diet energy. The simulations provide graphical and numerical descriptions of nutrient requirements, composition of gain, and estimates of animal performance over time. The model is accurate and precise, with a root mean squared error of 7.79% of the observed final body mass and a coefficient of determination of 0.89 when simulating the same variable. The model can be used as a reliable decision support tool to estimate final body mass and the days on feed required to reach a certain final mass with precision and accuracy. Moreover, the dynamic model can also serve as a learning tool to illustrate practical principles of animal nutrition, nutrient requirement relationships, and body composition changes. This model holds the potential to enhance livestock management practices and assist producers in making informed decisions about feedlot lamb production.
Behavior and Activity Patterns of the Critically Endangered Mangshan Pit Viper (Protobothrops mangshanensis) Determined Using Remote Monitoring
Authors: Deng Zeshuai , Ding Xiangyun , Zhang Bing , Li Linhai , Hou Dejia , Cao Yue , Chen Jun , Yang Daode
Published: August 2024

This study focuses on understanding the behavior and activity patterns of the critically endangered Protobothrops mangshanensis in China in order to better provide scientific data for upcoming artificial breeding and propagation efforts. We conducted a long-term observation of 15 Mangshan pit vipers at different sites in Hunan Province during the summer and autumn of 2021. Our methods involved analyzing the influence of environmental factors such as temperature, relative humidity, and light condition on the snakes’ day and night activity and behaviors. The results revealed that the wild behaviors of Protobothrops mangshanensis include resting, sunbathing, crawling, and exploring, with distinct rhythms in their diel behavior. The snakes’ diel activity exhibits three peak periods which may be related to food activity and sunbathing. This study also highlights the complex interplay of environmental factors on the activity of Protobothrops mangshanensis. Relative humidity was identified as a critical factor accounting for the difference in activity between observation groups. There was little inter-individual variation among the 15 Protobothrops mangshanensis, even though these snakes used terrestrial and arboreal habitats under different environmental conditions. These findings enhance our understanding of Protobothrops mangshanensis behavior and provide a basis for effective conservation measures for this rare and critically endangered species.
Zoonotic Tick-Borne Pathogens in Ticks from Vegetation and Alpine Ibex (Capra ibex) in the Maritime Alps, Italy
Authors: Menzano Arianna , Tizzani Paolo , Farber Marisa Diana , Garcia-Vozmediano Aitor , Martinelli Laura , Rossi Luca , Tomassone Laura
Published: August 2024

In the Maritime Alps (northwestern Italy), we collected ticks from vegetation and Alpine ibex (Capra ibex). Ixodes ricinus was the most abundant species in the study area, questing up to 1824 m a.s.l. and infesting 28 out of 72 ibexes. Haemaphysalis punctata, H. sulcata and Dermacentor marginatus were also collected. The abundance of questing ticks significantly decreased with altitude, with beechwoods being the preferred habitat. By PCR, we identified Borrelia burgdorferi s.l. in questing I. ricinus (28.3%; 95%CI: 19.4–38.6) but not in specimens collected from animals. Rickettsia spp. infected both questing (20.6%; 95%CI: 12.9–30.3) and on-host (30.2%; 95%CI: 21.2–40.4) I. ricinus. Anaplasma phagocytophilum was detected in 4.3% (95%CI: 1.2–10.8) of questing I. ricinus and in 45.3% (95%CI: 34.6–56.4) of I. ricinus collected from ibex. Female I. ricinus collected on animals were significantly more infected with A. phagocytophilum than females collected from vegetation (OR = 11.7; 95%CI: 3.8–48.1). By amplifying and sequencing a fragment of the groEL gene, we identified 13 groEL haplotypes, clustering with ecotypes I and II; ecotype I, prevalent in our sample, is considered zoonotic. Our study demonstrates the presence of different tick-borne zoonotic agents in the study area, encompassing a wide altitudinal range, as confirmed by the ticks found on ibex, a typical mountain-dwelling mammal. The results also confirm the altitudinal range expansion of ticks and associated pathogens in the Alps and suggest that Alpine ibex may act as a reservoir for A. phagocytophilum, as do other wild ungulate species.
Emergency Standing Laparoscopic Treatment of Uncontrolled Post-Castration Hemorrhage in Two Geldings
Authors: Delvescovo Barbara , McOnie Rebecca , Pearson Garett , Pugliese Brenna , Hackett Eileen S.
Published: August 2024

Background: Persistent hemorrhage of testicular vessels is a potentially life-threatening complication of equine castration. Frequently, general anesthesia is required to retrieve and ligate the bleeding vasculature when standing wound packing and retrieval of the spermatic cord are unsuccessful. We propose standing laparoscopic ligation of the testicular arteries via the paralumbar fossa as a rapid, effective means of halting hemorrhage while avoiding castration site trauma as well as the cardiovascular and recovery risks of general anesthesia. Methods: Two geldings, 6 and 9 months old, presented for emergency treatment of severe post-castration hemorrhage of 10 and 24 h durations, respectively. Both geldings underwent standing laparoscopy under light sedation and the testicular vessels were ligated using a bipolar vessel-sealing device. Results: Testicular vessel sealing was successfully performed in both geldings by standing laparoscopy and resulted in immediate cessation of hemorrhage. In one case, a left paralumbar fossa approach allowed coagulation of both the left and right spermatic vessels. The procedure time was 25 and 35 min. No complications occurred, and both geldings recovered uneventfully. Conclusions: Standing, laparoscopic ligation of the testicular arteries is a feasible emergency treatment in young geldings and can be applied in cases of uncontrolled post-castration hemorrhage.
Prevalence of Enteric Pathogens and Antibiotic Resistance: Results of a Six-Year Active Surveillance Study on Patients Admitted to a Teaching Hospital
Authors: Marascio Nadia , Pavia Grazia , Brescia Brunella , Riillo Concetta , Barreca Giorgio Settimo , Gallo Luigia , Peronace Cinzia , Gigliotti Simona , Pantanella Marta , Lamberti Angelo Giuseppe , Matera Giovanni , Quirino Angela
Published: August 2024

Background: Acute Infectious Diarrhea (AID) and the short- and long-term complications associated with it are major causes of hospitalization worldwide. In Italy, due to a lack of robust surveillance programs, only limited data has been collected on their prevalence and circulation. This study aims to evaluate the resistance pattern of enteric pathogens and their epidemiological trends over a six-year period. Methods: This cross-sectional retrospective study was conducted from January 2018 to December 2023. Stool samples were analyzed during routine diagnosis with culture methods, syndromic molecular tests, and enzyme immunoassay. Results: Bacteria were the most isolated enteric pathogens (62.2%), followed by fungi (29.0%), viruses (8.2%), and parasites (0.6%). Most bacteria were isolated from outpatients (29.5%) and from patients in the Oncology ward (26.2%). The most prevalent target was EPEC (11.1%), followed by C. difficile toxin A/B-producing strains (8.3%), C. jejuni (2.5%), and S. enterica, (1%.). Norovirus and Candida spp. were the most prevalent in pediatric patients (6.5% and 39.6%, respectively). In the last years, enteric pathogens have been a frequent cause of infections characterized by a problematic resistance to common antimicrobials. In our study, S. enterica showed resistance to amikacin, gentamicin, ampicillin, levofloxacin, and ciprofloxacin. C. jejuni was susceptible to all tested drugs. Conclusion: Timely notification of gastroenteric infections is crucial in identifying potential outbreak sources and ensuring strict adherence to food safety and hygiene practices, so as to protect the most vulnerable populations. The present study offers insights into the epidemiological characteristics and the antibiotic susceptibility of the main enteric AID pathogens in order to implement infection control measures in health care settings.
Plasma Antioxidant Capacity Is Related to Dietary Intake, Body Composition, and Stage of Reproductive Aging in Women
Authors: Tijerina Alexandra , Fonseca Diego , Aguilera-González Carlos J. , Heya Michel Stéphane , Martínez Nancy , Sánchez Nydia , Bouzas Cristina , Tur Josep A. , Salas Rogelio
Published: August 2024

Background: women aging is a normal process of life; however, hormonal changes create an imbalance between prooxidants and antioxidants and could be measured as the antioxidant capability (AC) of an organism. Objective: to find the association between plasma AC levels, dietary intakes, and body composition in 18–64-year-old women living in the northeast of Mexico. Methods: A total of n = 514 women (18–64 years old) were grouped according to STRAW criteria as reproductive, menopausal transition, and postmenopausal. Anthropometrics, body mass index (BMI), weight–hip ratio (WHR), and weight–height ratio WHtR were determined, and percentage of body fat was analyzed by bioelectrical impedance. Dietary intake of macronutrients and vitamins A, E, and C were analyzed by a 3-day food recall. The AC status in plasma was analyzed by the ORACFL assay. Results: Plasma AC levels were higher in postmenopausal women (815 µmol TE/L), and menopausal transition women (806 µmol TE/L) than in reproductive women (633 µmol TE/L). BMI was overweight (>25 kg/m2) in all three groups. WHtR and WHR are above the healthy limit of 0.5 and 0.8, respectively for both menopausal transition and postmenopausal women. In reproductive women, negative relationships were calculated between plasma AC and age (Rho = −0.250, p = 0.007), BMI (Rho = −0.473, p < 0.001), WHtR (Rho = −0.563, p < 0.001), WHR (Rho = −0.499, p < 0.001), and % body fat (Rho = −0.396, p < 0.001). A negative association was determined between plasma AC and WHtR in reproductive women (B = −2.718, p = 0.026). No association resulted for those in menopausal transition, and a positive association was obtained between plasma AC and protein (B = 0.001, p = 0.024) and vitamin E (B = 0.003, p = 0.013) intakes in postmenopausal women. Conclusions: the antioxidant capability (AC) in plasma was lower in reproductive women, and anthropometric parameters marking decreased physical fitness were associated with decreased AC.
A Novel BD2-Selective Inhibitor of BRDs Mitigates ROS Production and OA Pathogenesis
Authors: Lee Hyemi , Choe Jihye , Son Min-Hee , Lee In-Hyun , Lim Min Ju , Jeon Jimin , Yang Siyoung
Published: August 2024

Bromodomain and extra-terminal domain (BET) family proteins regulate transcription and recognize lysine residues in histones. Selective BET inhibitors targeting one domain have attracted attention because they maintain normal physiological activities, whereas pan (nonselective) BET inhibitors do not. Osteoarthritis (OA) is a joint disorder characterized by cartilage degeneration for which no treatment currently exists. Here, we investigated whether the selective inhibition of BET proteins is an appropriate therapeutic strategy for OA. We focused on the development and characterization of 2-(4-(2-(dimethylamino)ethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (BBC0906), a novel bromodomain 2 (BD2)-specific inhibitor designed to suppress OA progression. Using a DNA-encoded chemical library (DEL) screening approach, BBC0906 was identified because of its high affinity with the BD2 domain of BET proteins. BBC0906 effectively reduced reactive oxygen species (ROS) production and suppressed catabolic factor expression in chondrocytes in vitro. Moreover, in an OA mouse model induced by the destabilization of the medial meniscus (DMM), BBC0906 intra-articular injection attenuated cartilage degradation and alleviated OA. Importantly, BBC0906 selectively inhibits the BD2 domain, thus minimizing its potential side effects. We highlighted the therapeutic potential of targeting BET proteins to modulate oxidative stress and suppress cartilage degradation in OA. BBC0906 is a promising candidate for OA treatment, offering improved safety and efficacy.
Bump Feature Detection Based on Spectrum Modeling of Discrete-Sampled, Non-Homogeneous Multi-Sensor Stream Data
Authors: Lyu Haiyang , Zhong Qiqi , Jiao Donglai , Hua Jianchun
Published: August 2024

Roads are the most heavily affected aspect of urban infrastructure given the ever-increasing number of vehicles needed to provide mobility to residents, supply them with goods, and help sustain urban growth. An important indicator of degrading road infrastructure is the so-called bump features of the road surface (BFRS), which have affected transportation safety and driving experience. To collect BFRS, we can collect discrete-sampled, non-homogeneous multi-sensor stream data. We propose a BFRS detection method based on spectrum modeling and multi-dimensional features. With the sampling rate of GPS at 1 Hz and a gyroscope and accelerometer at 100 Hz, multi-sensor stream data are recorded at three different urban areas of Nanjing, China, using the smartphone mounted on a vehicle. The recorded stream data captures a geometric feature modeling movement and the respective driving conditions. Derived features also include acceleration, orientation, and speed information. To capture bump features, we develop a deep-learning-based approach based on so-called spectrum features. BFRS detection experiments using multi-sensor stream data from smartphones are conducted, and 4, 14, and 17 BFRS are correctly detected in three different areas, with the precision as 100%, 70.00%, and 77.27%, respectively. Then, comparisons are conducted between the proposed method and three other methods, and the F-score of the proposed method is computed as 1.0000, 0.6363, and 0.7555 at three different areas, which hold the highest value among all results. Finally, it shows that the proposed method performs well in different geographic areas.
Evaluation of Superparamagnetic Fe3O4-Ag Decorated Nanoparticles: Cytotoxicity Studies in Human Fibroblasts (HFF-1) and Breast Cancer Cells (MCF-7)
Authors: Ruíz-Baltazar Álvaro de Jesús , Reyes-López Simón Yobanny , Méndez-Lozano Néstor , Juárez-Moreno Karla
Published: August 2024

This study investigates the cytotoxicity profile of superparamagnetic Fe3O4-Ag decorated nanoparticles against human fibroblasts (HFF-1) and breast cancer cells (MCF-7). The nanoparticles underwent comprehensive characterization employing scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, X-ray photoelectron spectroscopy (XPS), and magnetic assays including hysteresis curves and zero-field-cooled (ZFC) plots. The nanoparticles exhibited superparamagnetic behavior as evidenced by magnetic studies. Cytotoxicity assays demonstrated that both HFF-1 and MCF-7 cells maintained nearly 100% viability upon nanoparticle exposure, underscoring the outstanding biocompatibility of Fe3O4/Ag decorated nanoparticles and suggesting their potential utility in biomedical applications such as drug delivery and magnetic targeting. Furthermore, the study analyzed the cytotoxic effects of Fe3O4 and Fe3O4-Ag decorated nanoparticles to evaluate their biocompatibility for further therapeutic efficacy. Results showed that neither type of nanoparticle significantly reduced cell viability in HFF-1 fibroblasts, indicating non-cytotoxicity at the tested concentrations. Similarly, MCF-7 breast cancer cells did not exhibit a significant change in viability when exposed to different nanoparticle concentrations, highlighting the compatibility of these nanoparticles with both healthy and cancerous cells. Additionally, the production of reactive oxygen species (ROS) by cells exposed to the nanoparticles was examined to guarantee their biosafety for further therapeutic potential. Higher concentrations (50–100 μg/mL) of Fe3O4-Ag nanoparticles decreased ROS production in both HFF-1 and MCF-7 cells, while Fe3O4 nanoparticles were more effective in generating ROS. This differential response suggests that Fe3O4-Ag nanoparticles might modulate oxidative stress more effectively, thus beneficial for future anticancer strategies due to cancer cells’ susceptibility to ROS-induced damage. These findings contribute to understanding nanoparticle interactions with cellular oxidative mechanisms, which are crucial for developing safe and effective nanoparticle-based therapies. This investigation advances our understanding of nanostructured materials in biological settings and highlights their promising prospects in biomedicine.
Thermodynamic Analysis and Performance Evaluation of Microjet Engines in Gas Turbine Education
Authors: Catana Razvan Marius , Cican Grigore , Badea Gabriel-Petre
Published: August 2024

This paper presents a detailed study on the main parameters and performance evaluation of microjet engines, at take-off regime and at various engine working regimes, based on thermodynamic analysis of a particular engine data library, from different engine manufacturers such as JetCat and AMT Netherlands. The studied engines have the same spool design but different thrust classes ranging from 97 to 1569 N. The particular data library includes engine specifications from catalogs or data sheets as well as our own experimental data from the JetCat P80 microjet engine, obtained using the ET 796 Jet Turbine Module, a complete testing facility for gas turbine education purposes. Various ratios and differences between certain engine main parameters and performances are studied in order to calculate values through which the analyses can be performed. Even if the engines have different thrust classes, the study examines if there are close values of the ratios and differences of parameters, that can be defined as reference parameters through which the engine performance can be compared and evaluated.
Evaluation of Non-Saccharomyces Yeast for Low-Alcohol Beer Production
Authors: Klimczak Krystian , Cioch-Skoneczny Monika , Poreda Aleksander
Published: August 2024

Among many methods to produce low/no-alcohol beers, using special yeasts has gained a substantial interest in the brewing industry. This approach relies on the fact that many non-Saccharomyces yeasts do not utilize maltose, which is the main sugar found in brewer’s wort. Additionally, these yeasts may allow the production of a beer with unique sensory characteristics. The aim of the study was to evaluate the potential of 18 non-Saccharomyces yeast strains in the production of low-alcohol beer. As a control strain, S. cerevisiae US-05 was used. The study consisted of two parts: microbiological evaluation and small-scale fermentations. In the microbiological part, ability to ferment sugars found in a wort, resistance to stress factors, phenolic off-flavor production, and enzymatic activities of β-glucosidase and β-lyase were evaluated. In the second part of the study, yeasts were used to produce a beer from 9.3 °Plato wort. During the fermentation, its dynamics was analyzed. The obtained beers were analyzed regarding their alcohol content, pH, acidity, and color. All of the evaluated strains produced low levels of alcohol. Two of the evaluated strains were characterized by especially high β-glucosidase activity. Based on the obtained results, six of the evaluated strains are promising in brewing.
Impact of Dried Garlic on the Kinetics of Bacterial Growth in Connection with Thiosulfinate and Total Phenolic Content
Authors: Wawrzyniak Jolanta , Drożdżyńska Agnieszka
Published: August 2024

The health properties of garlic (Allium sativum L.) are attributed to thiosulfinates, flavonoids, phenols, and bioactive polysaccharides. These compounds, however, can degrade during processing methods. As hot air-drying is a commonly used preservation method due to its relatively simple operation, this study investigated the effects of garlic slices dried at various temperatures (50, 70, and 90 °C) on the growth kinetic parameters of model strain Escherichia coli ATCC 25922, the total thiosulfinate content (TTC), and the total phenolic content (TPC). Observations showed that the concentration of garlic extracts was a significant factor influencing the kinetics of bacterial growth, while the garlic drying temperature appeared to have no effect on E. coli activity. Analysis of TTS in fresh and dried garlic did not reveal statistically significant differences in their levels. However, hot air drying at 50 °C significantly reduced the TPC by nearly 25%, whereas drying garlic at higher temperatures (70 °C and 90 °C) did not lead to a significant loss in TPC compared to the raw samples. The determined growth kinetic parameters of the tested E. coli strain could serve as a basis for selecting optimal drying process conditions and extract concentrations when designing garlic products with enhanced antimicrobial properties.
Studying the Efficiency of the Apache Kafka System Using the Reduction Method, and Its Effectiveness in Terms of Reliability Metrics Subject to a Copula Approach
Authors: Elshoubary Elsayed E. , Radwan Taha
Published: August 2024

This research envisages a system composed of three subsystems connected in series. Each subsystem comprises three units connected in parallel. For the system to function, at least one unit per subsystem must remain operational. Unit failure is governed by an exponential distribution, while unit repair is governed by either a general distribution or a Gumbel–Hougaard family copula distribution. The primary goal of this research is to compare the overall performance of our system under these two different regimes for performing repairs. Laplace transforms and supplementary variable methods are employed in solving the system. Our metrics for evaluating system performance are the availability, reliability, mean time to failure, and cost. The second goal of this research is to showcase a strategy for reduction that enhances the overall efficiency and availability of our system.
Targeted Lipid-Based Drug Delivery Systems for Lung Cancer Therapy
Authors: Apostolou Maria , Fatokun Amos A. , Assi Sulaf , Khan Iftikhar
Published: August 2024

The aim of this study was to review the literature to explore the lipid-based drug delivery systems that have been investigated for improved treatment of lung cancers. Such lipid-based drug delivery systems include microemulsions, liposomes, transferosomes, niosomes, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). In order to minimise the side effects of chemotherapeutic active pharmaceutical ingredients, surface modification with various ligands has been introduced so that the delivery system will attach only to specific receptors which are overexpressed in lung cancer cells. This review briefly explored cancers and their aetiologies and risk factors, especially lung cancer. It then discussed different modifications that have been performed on the drug delivery systems to successfully treat lung cancer. The use of different ligands has also been investigated in this review. The particle size of drug delivery systems after the attachment of the ligand remained small, varying from 75 to 189 nm, which was the most significant physicochemical property during development as it affected the delivery of particles to specific sites in the lungs. Overall, evidence suggests that surface modified lipid-based drug delivery systems have significant potential to revolutionise the treatment of lung cancer, leading to reduced side effects from chemotherapy.