bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional activity of corneal fibroblasts
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk Branch, Krasner K.Y. , Surovtseva M.A. ,   S. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk Branch, Chernykh V.V. ,   Research Institute of Clinical ans Experimental Lymphology - Branch of the Institute of Cytology and Genetics SBRAS
Published: December 2020

Актуальность. В качестве источника клеток для регенерации роговицы рассматриваются многие типы клеток, включая фибробласты роговицы(ФР). Трансплантированные клетки подвергаются окислительному стрессу в месте повреждения, что приводит к снижению их жизнеспособности и увеличению апоптоза. Эритропоэтин (ЭПО) обладает антиапоптотическим и антиоксидантным действием. Цель. Изучить функциональную активность ФР под влиянием ЭПО. Материал и методы. Фибробласты роговицы выделяли ферментативным методом из стромальных лентикул, полученных при кераторефракционной операции (КРО) методом ReLEx SMILe.Клетки культивировали в стандартных условиях в полной среде DMEM/F12. После третьего пассажа проводили дифференцировку клеток в кератоциты. Фенотип клеток определяли на проточном цитофлуориметре. ФР обрабатывали рекомбинантным эритропоэтином человека 33,4 Ед/мл. Пролиферацию ФР оценивали в МТТ-тесте через72 ч после обработки ЭПО. Горизонтальную миграцию ФБ изучали через 48ч после обработки ЭПО на микроскопе Axio Observer Z1. Оценивали способность полученной популяции клеток образовывать 3D-культуры в среде GrowDex (UPMBiomedicals, Finland). Статистическая обработка результатов – ПО «Statistica 10.0». Результаты. Культура была представлена, преимущественно, фибробластоподобными клетками. Клетки имели фенотип (CD90+/CD73+/CD105+/keratocan–/lumican–/ALDH-2+). Данные клетки обладали способностью к цитодифференцировке в кератоциты с фенотипом (CD90+/CD73+/CD105+/keratocan+/lumican+/ALDH-2+). ЭПО достоверно увеличивает миграцию клеток через 8 и 16ч(p=0.04), не оказывая влияние на пролиферативную активность ФР. Полученная популяция клеток формирует стабильную 3D культуру в течение более 2 недель. Выводы. ФР стромальных лентикул роговицы обладают функциональным потенциалом в качестве источника для регенерации роговицы.
The quality of life in сase of children with diabetes mellitus type 1
Authors:   Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan, Krivolapova D.A. , Abdullina V.R. ,   Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan, Kassymbekova G.N. ,   Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan, Sukbye A.D. ,   Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan
Published: December 2020

Актуальность. В настоящее время сахарный диабет 1-го типа (СД 1), наряду с другими хроническими заболеваниями, является одним из самых прогрессирующих заболеваний. По данным ВОЗ, к 2030 году СД займет 7 место в мире среди заболеваний, приводящих к летальному исходу, т.к. наряду с атеросклерозом и раком входит в тройку заболеваний, приводящих к инвалидности. Цель. Изучение уровня качества жизни детей сСД 1-го типа. Материал и методы. В исследовании участвовали 74 ребёнка. Из них мальчиков было 36 (48,6%),девочек - 38 (51,4%). Сельских жителей было – 14(18,9%) и 60 городских (81,1%). Инсулинотерапия проводилась у 34 пациентов (46%) с помощью помпы, у 40 (54%) – на ручках. Основной базой для оценки КЖ в исследовании являлась русифицированная версия опросника SF-36. Опросник отражает общее благополучие и степень удовлетворенности теми сторонами жизнедеятельности человека, на которые влияют состояние здоровья. Результаты. Выборка была стратифицирована по группам согласно показателям гликированного гемоглобина (HbA1) независимо от пола и возраста. Средние показатели КЖ значительно отличались от 100% уровня «идеального» здоровья. Наибольшее количество баллов наблюдалось по шкале «интенсивность боли» (BP) – 85,95% и «ролевое функционирование, обусловленное эмоциональным состоянием» (RE) – 78,22933%. Наименьшее количество баллов наблюдалось по шкале «психическое здоровье» (MH) - 50,08% и «жизненная активность»(VT) – 54%. Основные показатели качества жизни пациентов в группе, получающих помповую инсулинотерапию, практически не отличались от показателей КЖ детей, которые получали инсулин спомощью ручек. Выраженные изменения показателей качества жизни регистрировались независимо от пола. Выводы. 1. Показатели общего состояния здоровья (GH), жизненной активности (VT) и психического здоровья (MH) подвергаются значительным изменениям у пациентов, страдающих СД1-го типа, во всех группах независимо от возрастаи пола. 2. Основные показатели качества жизни пациентов в группе, получающих помповую инсулинотерапию, практическии не отличались от показателей КЖ детей, которые получали инсулинс помощью ручек. Выраженные изменения показателей качества жизни, которые определяли оптимальную адаптацию в микросоциуме, регистрировались независимо от пола.
Development of method of implantation of new model artificial iris-lensdiaphragm for surtureless transcleral fixation in case without capsule supportin an experimental study ex vivo
Authors:   FSAU «NMIC» MNTC «eye microsurgery» named after Acad. S. N. Fedorov «Ministry of health of the RussianFederation, Soboleva M.A. , Borzenok S.A. ,   FSAU «NMIC» MNTC «eye microsurgery» named after Acad. S. N. Fedorov «Ministry of health of the RussianFederation, Sobolev N.P. ,   FSAU «NMIC» MNTC «eye microsurgery» named after Acad. S. N. Fedorov «Ministry of health of the RussianFederation, Shkandina Y.V. ,   FSAU «NMIC» MNTC «eye microsurgery» named after Acad. S. N. Fedorov «Ministry of health of the RussianFederation
Published: December 2020

Актуальность. В настоящее время для закрытия протяженных дефектов радужной оболочки (РО) у пациентов при отсутствии капсульной поддержки имплантируют иридохрусталиковую диафрагму (ИХД) с дополнительной шовной фиксацией к склере. Однако проблема биодеградации шовного материала является основой для поиска альтернативного, надежного метода фиксации интраокулярных имплантов. Цель. Разработать способ имплантации ИХД при аниридии и афакии, осложненной отсутствием капсулы хрусталика. Материал и методы. Материалом для проведения экспериментального исследования ex vivoпослужили 6 глазных яблок доноров (ГЯД). Отбор проводили исходя из критериев: 1. Возраст доноров – до 55 лет. 2. Время от момента смерти до имплантации – не более 24 часов. На всех глазах была смоделирована аниридия, афакия. В основной группе (3 ГЯД) была имплантирована новая модель ИХД для бесшовной транссклеральной фиксации в область цилиарной борозды, дополнительно снабженной тремя опорными элементами из эластичного полиморфного материала в виде копья. В контрольной группе (3 ГЯД) - МИОЛ-радужка, модельН1, требующая дополнительную шовную фиксацию. ИХД в обеих группах были производства ООО «Репер-НН». Для оценки положения импланта были выполнены: биомикроскопия, ультразвуковая биомикроскопия (УБМ), фоторегистрация. Результаты. Согласно биомикроскопическим данным и УБМ, проведенных в обеих группах, ИХД занимала центральное положение, была прочно фиксирована к внутриглазным структурам. Выводы. На основе проведенного экспериментального исследования ex vivo доказана возможность бесшовной фиксации новой модели ИХД при отсутствии капсульной поддержки, что может служить основанием для дальнейшего изучения эффективности использования данного имплантав клинических условиях.
Comparison of the Clinical and Refractive Outcomes of Foldable and RigidIntraocular Lens Implantation following Penetrating Keratoplasty (PK)
Authors:   School  of medicine, Peoples’ Friendship University of Russia, Moscow City, Russian Federation, Tanash M.A. , Frolov M.A. ,   School  of medicine, Peoples’ Friendship University of Russia, Moscow City, Russian Federation, Gonchar P.A. ,   School  of medicine, Peoples’ Friendship University of Russia, Moscow City, Russian Federation, Ababneh L.T. ,   School of Medicine, Jordan University of Science and Technology King Abdullah University Hospital, Irbid city, Jordan
Published: December 2020

Цель. Сравнить клинические и рефракционные результаты имплантации эластичных и жестких интраокулярных линз (ИОЛ) после сквозной кератопластики (СКП). Материал и методы. Ретроспективное сравнительное исследование проводилось в офтальмологическом отделении Университетской больницы им. короля Абдаллы (KAUH) в Иордании с марта2018 года по май 2019 года. В исследование включено 95 пациентов, которым была выполнена экстракция катаракты после сквозной кератопластики по поводу кератоконуса, герпетической кератопатии, и травмы глаза. Пациенты разделены на 2группы. Первую группу составили 60 пациентов, перенесших экстракцию катаракты методом факоэмульсификации с имплантацией различных эластичных ИОЛ. Вторую группу составили 35 пациентов, которым провели экстракцию катаракты выполняли по протоколу тонельной экстракции(мини nuc.) с имплантацией жестких линз. Выбор жесткой линзы осуществлялся из-за критического уровня эндотелиальных клеток (ПЭК) и катаракты4 и 5 степени плотности ядра для исключения дополнительной травмы эндотелия ультразвуком факоэмульсификатора. Всем пациентам, проводили офтальмологические обследования по протоклолу сквозной кератопластики. Клинический материал проанализирован статистической программы R(р<0,05). Результаты. Кератоконус был наиболее распространенным показанием для сквозной кератопластики у мужчин (63,2%, р<0,05), и у женщин(66,6%, р<0,05). Максимальная острота зрения с коррекцией в первой группе улучшилась с 0,1±0,05перед операцией до 0,8±0,05 после операции и с0,3±0,05 до 0,7±0,05 у второй группы. В позднем послеоперационном периоде показатели остроты зрения при имплантации эластичных ИОЛ дали более высокие показатели, по сравнению с результатами, полученными при применении жестких ИОЛ, на 0,1±0,05. Выводы. Экстракция катаракты на глазах с кератоконусом после сквозной кератопластики безопасна и эффективна. Послеоперационная острота зрения мало зависит от типа имплантируемой ИОЛ. На наш взгляд, разница в остроте зрения между первой и второй группами, можно объяснить состоянием трансплантата.
Assessing effectiveness of new approach to barrier amnioplasty in surgicaltreatment of primary pterygium
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,Khabarovsk, Russian Federation, Bochkareva А.N. , Smoliakova G.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,Khabarovsk, Russian Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,Khabarovsk, Russian Federation, Banshchikov P.А. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,Khabarovsk, Russian Federation, Pilipenko А.D. ,   Postgraduate Institute for Public Health Specialists, Khabarovsk, Russian Federation
Published: December 2020

Актуальность. В связи с высокой частотой рецидива (40–70%) после хирургического лечения птеригиума продолжается поиск новых, более эффективных хирургических подходов к проведению барьерной амниопластики. Цель. Оценить эффективность предложенного способа барьерной амниопластики при хирургическом лечении первичного прогрессирующего птеригиума. Материал и методы. Исследование проведено у40 пациентов (40 глаз) с первичным прогрессирующим птеригиумом, которые были разделены на две группы. Основную группу составили 20 пациентов(20 глаз), которым после удаления головки птеригиума была проведена амниопластика в зоне полулунной складки по предложенной нами методике. Пациентам контрольной группы (20 человек – 20глаз) выполнена барьерная амниопластика у лимба. Результаты. Анализ показателей раневого процесса показал, что в основной группе по сравнению с контрольной достоверно быстрее проходили репаративные процессы (р<0,05), а именно купирование воспалительной реакции конъюнктивы – 7,1±0,1 сут. и 11,3±0,3 сут. соответственно, эпителизация роговицы – 7,7±0,2 сут. и 12,9±04 сут. соответственно, а также нормализация рН слезы –9,1±0,2 сут. и 14,0±0,5 сут. соответственно. Сравнительная цитологическая картина мазков-отпечатков показала, что клеточный составраневой поверхности в основной группе нормализовался к 7–9 сут., в то время как в контрольной к 12–15 сут. В отдаленном периоде отмечена достоверно большая острота зрения в основной группе –0,74±0,1 по сравнению с контрольной – 0,54±0,1(р<0,05). Рецидив птеригиума в сроках наблюдения до 1года произошел у 3 пациентов контрольной группы, в то время как в основной группе рецидивов незарегистрировано. Выводы. Предложенная технология хирургического лечения первичного птеригиума позитивно влияет на течение воспалительно-репаративных процессов в зоне хирургического вмешательства, предотвращая развитие рецидивов птеригиума.
Experience of FSUE “RADON” on decommissioning of radiation and nuclear hazardous facilities and remediation
Authors:   FSUE “RADON”, Diordiy M. N. , Chabanyuk A. I. ,   FSUE “RADON”
Published: December 2020

For many years FSUE “RADON” has been dealing with decommissioning of nuclear facilities, comprehensive engineering and radiation surveys, remediation of territories contaminated with radioactive nuclides as a result of industrial or scientifi c activities or radiation accidents. Extensive knowhow and knowledge have been accumulated in this fi eld to date with typical problems hindering proper execution of these activities being identifi ed. This article summarizes the experience of FSUE “RADON” in the fi eld of decommissioning and remediation with typical problems being analyzed and relevant measures proposed to address them.
Application of a Specifi c Indicator for the Estimation of Radioactive Wastes Generation Volumes During Normal Operation of Nuclear Power Plants in Russia
Authors:   Institute of Industrial Ecology, Ural Branch, Russian Academy of Sciences, Ekidin A. A. , Antonov K. L. ,   Institute of Industrial Ecology, Ural Branch, Russian Academy of Sciences
Published: December 2020

Generation of radioactive wastes (RW) is viewed a most urgent problem of radiation safety under normal operation of nuclear power plants (NPP). The paper demonstrates the application of a specifi c indicator (rate) of RW generation per unit of generated power (m3/GW·h) for a retrospective assessment and forecasting of RW generation volumes at Russian NPPs. Mean and median values of annual specifi c RW generation rates were calculated for each NPP based on published environmental reports of JSC Rosenergoatom Concern for the period of 2008—2018. Advantage of applying median values in retrospective and forecast assessments was shown. Medians for solid very low-level, low-level, intermediate-level and high-level radioactive waste amounted to 1.5·10−2 m3/GW·h, 3.3·10−2 m3/GW·h, 3.3·10−3 m3/GW·h and 2.8·10−4 m3/GW·h, respectively; for liquid low-level and intermediate-level waste these values accounted for 1.4·10−3 m3/GW·h, 2.5·10−3 m3/GW·h, respectively. NPPs with RBMK reactor units are characterized by the highest mean and median values of specifi c RW generation rates for all RW categories. Given various types of reactor facilities and their characteristic specifi c rates, retrospective estimates for the total volume of liquid RW was increased by 8 % and for solid RW — by 12 %. The forecast estimates based on specifi c rate medians, as well as on increased power generation planned for Russian NPPs indicates probable increase in RW generation volumes by 0.8—7.1 % (depending on waste category) from 2020 to 2027.
Potential of a "Digital Twin" Technology for the Purposes of Research in the Nizhnekanskiy Rock Mass Underground Research Laboratory
Authors:   JSC ", Kononov V. V. ,   NEOLANT", Tikhonovsky V. L. ,   JSC "NEOLANT", Guralev S. S. ,   JSC "NEOLANT", Bychkova I. A. ,   JSC "NEOLANT", Utkin S. S. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Svitelman V. S. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: December 2020

The paper highlights key aspects associated with the introduction of advanced digital technologies under the development of large complex industrial facilities. It considers the applicability of a "digital twin" technology in the development of an underground research facility in the Niznekanskiy massif (Krasnoyarsk territory) (URF NKM).
Purification Method for Filtrate from the Treatment of Process Uranium-Containing Solutions
Authors:   Joint Stock Company “A.A. Bochvar High-technology Research Institute of Inorganic Materials”, Varlakov A. P. , Germanov A. V. ,   Joint Stock Company “A.A. Bochvar High-technology Research Institute of Inorganic Materials”, Mariakhin M. A. ,   Joint Stock Company “A.A. Bochvar High-technology Research Institute of Inorganic Materials”, Volgin D. S. ,   Joint Stock Company “A.A. Bochvar High-technology Research Institute of Inorganic Materials”, Varlakova G. A. ,   Joint Stock Company “A.A. Bochvar High-technology Research Institute of Inorganic Materials”, Svetashev G. O. ,   Joint Stock Company “Production Association “Electrochemical plant”, Bogatov M. B. ,   Joint Stock Company “Production Association “Electrochemical plant”
Published: December 2020

The article describes the purification method for filtrate generated from the treatment of process uranium-containing solutions that resulted from production activities at JSC “PA ECP”. The paper presents the stages of the testing performed at a laboratory stand that enabled to identify an optimal concept flowchart for filtrate treatment.
Radiation Characteristics of Borosilicate Glass Containing High-Level Waste
Authors:   V. G. Khlopin Radium Institute, Aloy A. S. , Blokhin A. I. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Blokhin P. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Kovalev N. V. ,   V. G. Khlopin Radium Institute
Published: December 2020

The article presents computational and analytical studies dealing with radiation characteristics of liquid high-level waste vitrified using borosilicate glass (BSS). To confirm the quality of glass on a time scale of up to 10 4 years and more, computational and experimental studies are performed to identify the dose loads on the BSS from all types of radiation. The paper presents the results of computational studies focused on radionuclide composition and radiation characteristics of a BSS produced during the reprocessing of spent nuclear fuel from VVER-1000 reactors based on a method developed by JSC Radium Institute named after V. G. Khlopin.
Pengaruh Bauran Pemasaran dan Destination Image Terhadap Keputusan Wisatawan Berkunjung Pada Pada Pariwisata Syariah Di Kabupaten Lima Puluh Kota Provinsi Sumatera Barat
Authors: Muhammad Yusuf Muhammad Yusuf
Published: December 2020

The purpose of this study is to determine whether there is a partially and simultaneously influence among product, promotion, place, price, people, physical evidence, process, promise, patience and destination image variable on the decision of tourists visiting sharia tourism in Lima Puluh Regency, West Sumatra Province. This research is field research with quantitative research methods. The data collecting techniques of this study were questionnaire, documentation, and interviews with the respondents, which consist of 100 people. The research location of this study was in Lima Puluh Kota. In processing data, this study utilized SPSS for Windows program 23.0 version.Based on the research results, it is obtained that (1) marketing mix consisting of variables (product, price, place, promotion, people, process, physical evidence, promise, patience) has a positive influence on the decision of tourists visiting sharia tourism, , (2) destination image has a positive influence on the decision of tourists visiting sharia tourism, the marketing mix and destination image simultaneously influence the decision of visiting tourists by 44,019. It means that the product, price, place, promotion, people, process, physical evidence, promise, patience, and destination image variable simultaneously influence the decision of tourists visiting sharia tourism in the Lima Puluh regency of West Sumatra Province.

Keywords: Sharia Marketing Mix, Destination Image, and Tourist Visit Decision, Sharia Tourism
On the Issue of Publishing about Peter the Great in the First Korean Magazine Sonen “Youth” (1908)
Authors:   Saint Petersburg State University, Gurievа А. A.
Published: December 2020

The paper introduces the specifics of the Sonyeon (“Youth”) journal, where the first text on Peter the Great in Korea was published, and considers publication activities of Choe Nam-seon (1890–1957), a leading representative of the Enlightenment movement. It also analyzes the influence of this context on the later perception of the figure of the Russian Tzar.
Sources on the History of Siberia in the First Half of 18th Century: Drawings of Artists of the Second Kamchatka Expedition
Authors:   Institute of History SB RAS, Shipilov I. A.
Published: December 2020

The article based on complex analysis of geographical, naturalistic (botanic, zoological, mineralogical), archaeological and ethnographic drawings performed by artists of the academic detachment of the Second Kamchatka expedition J. Ch. Berckhan, J. W. Lürsenius, J. C. Decker is shown importance of these works as subject-matter and disciplinary scientific illustrations representative of development the Russian science. It is revealed that the images of the named artists are realistic visual representations of the past of Siberia and should be used together with the scientific works of the participants of the Second Kamchatka Expedition to study the history of the region. The qualitative characteristics of naturalistic and archaeological drawings allow for the reconstruction of museum collections that have not preserved to this day. It is concluded that drawings of J. Ch. Berckhan, J. W. Lürsenius, J. C. Decker are picturesque memorial monuments of the Russian pictural art, valuable sources on the history of exploration of Siberia and visual history of Russia in the modern period.
Editorial
Authors: Parayre Catherine
Published: December 2020

Editorial, Voix plurielles 17.2 (2020)
Les nouveaux défis du théâtre du vingt-et-unième siècle
Authors: French French
Published: December 2020

L’essor des nouvelles technologies et la diversité des média représentent une nouvelle étape dans l’évolution permanente du théâtre. Dès la seconde moitié du vingtième siècle le domaine des arts s’inspire de procédés techniques innovants et multiplie les performances expérimentales qui redéfinissent la théâtralité, la scène, le hors-scène et la réception. Les fondements du théâtre sont-ils pour autant remis en question ? D’autre part, l’ère numérique, tout en inspirant de nouvelles expressions artistiques, offre des outils de communication qui vont modifier la réception, favoriser l’interactivité et l’implication du spectateur et mettre au jour de nouveaux challenges. Dans cet article nous porterons notre attention sur les nouveautés technologiques de l’ère numérique, les éléments constitutifs des nouvelles formes de théâtre et les attentes ainsi que le rôle du récepteur en essayant de redéfinir les stratégies et objectifs de l’art théâtral.

Mots clés : Technologies, performance, interactivité, multimédia, postdramatique
« Théâtre immersif » et spécificité théâtrale : une question d’équilibre
Authors: Lombi Emily
Published: December 2020

À l’aube du vingtième siècle, une poignée d’hommes de théâtre questionnent la relation acteur-spectateur et le rapport scène-salle à travers de nouvelles initiatives à l’exemple de celles menées, en Russie, par le metteur en scène Vsevolod Meyerhold qui, dans l’optique d’optimiser l’activité du spectateur, brise le quatrième mur et cherche de nouveaux dispositifs scéniques. Les expériences de ce réformateur, auxquelles peuvent s’en ajouter d’autres, préparent d’une certaine manière celles que nous connaissons aujourd’hui sous le terme de « théâtre immersif » et qui se sont particulièrement affirmées depuis les années quatre-vingt-dix. Or, dans quelle mesure ces dispositifs répondent-ils toujours aux spécificités du théâtre ? Pour apporter une réponse à cette interrogation, nous proposons de montrer non seulement la continuité d’expériences immersives dans l’histoire du théâtre, mais aussi d’en saisir le fonctionnement et les objectifs sur la scène actuelle à travers un regard posé sur le travail de Léonard Matton autour du spectacle Helsingør-château d’Hamlet (Paris, 2018), et sur celui de la compagnie Thespis autour du spectacle Shakespeare’s Ghosts (Lyon, 2019).

Mots clés : immersif, théâtre, spectateur, acteur
Réanimer le musée. Récit et analyse d’une expérience de recherche-création
Authors: French French
Published: December 2020

Cet article se propose de revenir sur une expérience de recherche-création menée dans un musée d’art et d’histoire de la région parisienne entre 2017 et 2018. Marionnettiste, performeuse mais aussi chercheuse, l’autrice s’y interroge, à la première personne, sur la confrontation des désirs et des fantasmes théoriques à leur réalisation pratique. S’agissait-il vraiment de « faire entrer les arts vivants au musée » comme l’annonçait certains médias locaux ? D’occuper l’espace, de se saisir du lieu, des œuvres ? A quels prix et pour quels effets ?

Retraçant presque chronologiquement ce parcours, cet article se fait le portrait sinueux d’une recherche qui se (re)trouve en actes et se transforme à l’œuvre.

Mots clés : recherche-création, théâtralité, musée, marionnette, performance
Le postcolonial et les écritures francophones : pertinence et état des lieux
Authors: French French , Roch Alexandra
Published: December 2020

Dossier : Le postcolonial et les écritures francophones : pertinence et état des lieux

Introduction
Revendication et expression de liberté dans les dramaturgies africaines postcoloniales chez Sony Labou Tansi et Bottey Zadi Zaourou
Authors: French French
Published: December 2020

L’Afrique, depuis les indépendances, vise à authentifier sa liberté par la voie de la littérature, notamment le théâtre. Si les dramaturges africains dits de la première génération l’ont affirmée en créant suivant les modèles de création théâtrale hérités de l’Occident, ceux dits de la deuxième génération, se sont frayé une voie totalement nouvelle dans l’écriture théâtrale. Cette voie nouvelle est surtout subversive car les seconds reprochent aux premiers leur conformisme aveugle aux modèles de création d’origine occidentale. Leur souci majeur est d’affranchir l’écriture théâtrale africaine des conventions établies, des formes stéréotypées et de la rigidité de la langue française et lui donner une coloration plus africaine.

Mots-clés : Conformisme, Canons dramaturgiques établis, Transgression, Innovations dramaturgiques, Liberté dramaturgique, Identité africaine
Et Pilate s’est lavé les mains : rhapsodie en cinq actes
Authors: Viselli Sante
Published: December 2020

Texte de création
Simon sur les planches des Feluettes de Michel Marc Bouchard
Authors: French French , Lestage Stéphane
Published: December 2020

Entretien accordé à Marie Pascal, Université Dalhousie

Comme Michel Marc Bouchard, Stéphane Lestage a étudié au département de théâtre de l’Université d’Ottawa. Après ces débuts dans le Britanicus de Racine au Centre National des Arts d’Ottawa, il est recruté par Brigitte Haentjens au Théâtre du Nouvel-Ontario de Sudbury pour y jouer le rôle de « Ti-Jean », personnage légendaire de la tradition orale du nord de l’Ontario. La saison suivante, il jouera dans Nickel, aussi du TNO, et c’est à cette occasion qu’il fera une tournée (Ontario, Québec et dans les maritimes) en compagnie de Michel Marc Bouchard. Suite à cette tournée, le dramaturge le recrute pour jouer Simon lors de la création des Feluettes à L’Atelier du CNA (Ottawa). De retour à Montréal, Stéphane jouera surtout à la télévision pendant quelques années, puis fera ensuite une transition vers les domaines plus techniques du cinéma et de la télévision.
Huyghebaert, Céline. Le drap blanc
Authors: Defraeye Julien
Published: December 2020

Huyghebaert, Céline. Le drap blanc

Compte rendu
Functional and rheological properties of mixed flour from mangrove fruit of Bruguiera gymnorrhiza flour and wheat flour
Authors: Amin M.N.G. , Pebruwantoro D. , Pralebda S.A. , Hasan M.N. , Zakariya  , Subekti S. , Pramono H. , Alamsjah M.A.
Published: December 2020

In order to yield influential information on the most recommended use of BGF, which so
far still questioned, this preliminary study was aimed to investigate the physicochemical
and functional properties of mixed flour of BGF and wheat flour (WF). A total of nine
mixtures of WF: BGF of (90%:10%; 80%:20%; 70%:30%; 40%:60%; 50%:50%;
40%:60%; 30%:70%; 20%:80%; 10%:90%) were produced, where single WF and BGF
were used as controls. This research revealed the different amount of BGF and wheat flour
in the mixed flour showed the significantly different value of functional and rheological
properties attributes, such as bulk density, CI, HR, WAI, WSI, SP, OAC, peak viscosity,
trough viscosity, breakdown viscosity, final viscosity, setback viscosity and peak time.
We have inferred to some previous studies and speculated that the difference in functional
and rheological properties could be caused by the different amylose and amylopectin
amount in the mixed flour. As far as we know that this present study was the first study on
the mixed flour of BGF and wheat flour, therefore we suggested a more comprehensive
study such as investigation of baking performance and bread qualities.
Clinical Case of Arteriovenous Malformation in a Pregnant Woman
Authors:   Kharkiv National Medical University. 4, Nauky Avenue, Kharkiv 61022, Ukraine, Abdullaeva N. A. , Cherepova V. I , Tovazhnyanska O. L. , Lazurenko V. V.
Published: December 2020

Extragenital pathology during pregnancy and childbirth occupies a leading place in maternal mortality and perinatal pathology. One of the main ways to maintain the health of mother and child is to identify somatic diseases in pregnant women and timely treat them. Nervous system diseases that occur in pregnant women are mainly epilepsy, multiple sclerosis, brain tumors, cerebrovascular disorders, although remain poorly understood, but require immediate decisions to prolong pregnancy, obstetric tactics during childbirth, conservative or conservative surgery. The pathology of cerebral vessels (arterial aneurysms and arteriovenous malformations) also remains an urgent problem, despite many years of experience in their diagnosis and treatment. The sudden development of symptoms, severity of clinical manifestations and high mortality in rupture of an aneurysm or arteriovenous malformation of cerebral vessels determine the urgency of this problem and increased interest in its study, especially in pregnant women. Material and methods. The paper presents a clinical case of arteriovenous malformation in a 25-year-old pregnant woman, her treatment and delivery. Results and discussion. Arteriovenous malformation is considered a congenital cerebrovascular pathology, which is accompanied by a sudden rupture of abnormal vessels with the development of hemorrhagic stroke, without specific clinical symptoms and precursors, which complicates lifelong diagnosis. Endovascular embolization during pregnancy saved the lives of women and children. An effective result was obtained after neurosurgical treatment of arteriovenous malformation in a pregnant woman in the second trimester of pregnancy (17 weeks), which allowed to bring the pregnancy to the physiological time of delivery. Taking into account the complex neurological pathology, neurosurgery, which requires the exclusion of a powerful period of childbirth, a pregnant woman gave birth by cesarean section at 38 weeks of pregnancy. Conclusion. An effective result was obtained after neurosurgical treatment of arteriovenous malformation in a pregnant woman in the second trimester of pregnancy, which allowed to bring the pregnancy to the physiological time of delivery. The obtained results indicated the possibility of full-term pregnancy, reduction of maternal and perinatal morbidity and mortality in pregnant women with arteriovenous malformation with timely preventive and curative measures with timely referral of pregnant women to the perinatal center on the basis of a multidisciplinary clinical institution to prevent complications
Possibilities of Clinical Neurovisualization Verification of Spontaneous Supratentorial Intracerebral Hemorrhage Acute Period Course Prognosis on the Ground of Conservative Treatment
Authors:   Zaporizhzhia State Medical University. 26, Mayakovsky Avenue, Zaporizhzhia 69035, Ukraine, Kozyolkin O. A. , Kuznietsov A. A.
Published: December 2020

The aim of the study – to improve the diagnostic measures in patients with spontaneous supratentorial intracerebral hemorrhage through elaboration of the prognostic criteria for the early neurological deterioration on the ground of comparative analysis of clinical scales that evaluate the severity of patient’s condition. Materials and methods. Prospective, cohort investigation of 339 patients (mean age 64,8±0,6 years) in acute period of spontaneous supratentorial intracerebral hemorrhage was done. The diagnosis was made on the ground of clinical, neurovisualization examination. Initial patient’s condition severity was estimated by using the National Institute of Health Stroke Scale (NIHSS), Full Outline of UnResponsiveness (FOUR) Scale, Glasgow Coma Scale, original Intracerebral Hemorrhage Scale (oICH), modified Intracerebral Hemorrhage Scales (mICH-A, mICH-B), Intracerebral Hemorrhage Grading Scale (ICH-GS), Intracerebral Hemorrhage Functional Outcome Scale (ICH-FOS). The early neurological deterioration was used as a cumulative end-point. It was detected as onset of one or some events from the following during 24 hours from the admission on the ground of conservative therapy: 1) decrease of FOUR score ≥2; 2) increase of NIHSS score ≥4; 3) lethal outcome. Logistic regression and ROC-analysis were used for prognostic criteria elaboration. Results. Clinical neurological deterioration during 24 hours from admission was revealed in 99 (29,2%) patients. On the ground of univariate logistic regression analysis it was detected that the risk of early neurological deterioration in patients with spontaneous supratentorial intracerebral hemorrhage on the ground of conservative therapy is evaluated as the following summary score: oICH (OR (95% CІ) = 2,71 (2,07–3,55), р˂0,0001), mICH-A (OR (95% CІ) = 1,70 (1,50–1,93), р˂0,0001), mICH-B (OR (95% CІ) = 1,81 (1,57–2,09), р˂0,0001), ICH-GS (OR (95% CІ) = 1,91 (1,59–2,29), р˂0,0001) and ICH-FOS (OR (95% CI) = 1,40 (1,28–1,54), р˂0,0001). It was detected that mICH-A and mICH-B scales differ with higher AUC values compared with oICH, ICH-GS and ICH-FOS concerning early neurological deterioration prediction in patients with spontaneous supratentorial intracerebral hemorrhage. Conclusions. Early neurological deterioration predictors in patients with spontaneous supratentorial intracerebral hemorrhage during 24 hours from the admission are the mICH-A score >4 (sensitivity = 71,7%, specificity = 78,8%) and mICH-B score >2 (sensitivity = 82,8%, specificity = 63,8%)
Peculiarities of Prescribing Mucolytic Therapy to Children in Post-Attack Period of Bronchial Asthma
Authors:   Higher State Educational Establishment of Ukraine Bukovinian State Medical University. 2, Theatralna Sq., Chernivtsi 58002, Ukraine, Sazhyn S. I.
Published: December 2020

Bronchial asthma is the most common chronic pathology in childhood. Chronic inflammatory process of the respiratory tract forms bronchial hyperreactivity which is manifested by typical clinical symptoms. Like any other chronic disorder, the course of bronchial asthma consists of periods of exacerbation and remission. A productive cough in the post-attack period determines the prescription of mucolytic drugs by doctors to liquefy viscous sputum, to remove it more quickly, especially among the paediatric population. There are different approaches to prescribing mucolytic drugs during exacerbation of symptoms of bronchial asthma in scientific publications. The purpose of the study was to evaluate the clinical effectiveness of mucolytic therapy in children with bronchial asthma to optimize the treatment of disease exacerbations. Material and methods. One hundred two medical records of patients treated for asthma exacerbation in pulmonological department of the Chernivtsi Regional Children Clinical Hospital were analyzed. Four clinical groups were formed depending on the prescription of mucolytic drugs. There were not any significant differences by sex, place of residence, however the average age of patients who were prescribed carbocisteine. It was significantly less than in children of other clinical groups. Results and discussion. It was determined that acetylcysteine and carbocysteine were prescribed to patients on the first day of the productive cough onset. Instead to children of the IV clinical group where ambroxol was prescribed on average 1.6 days before the wet cough onset. The study results showed that the average duration of hospitalization in patients receiving ambroxol was 1.5 days less than in children taking acetylcysteine or carbocysteine. The difference was significant. However, the duration of hospitalization for children of I clinical group was not significant longer in comparison with patients received drugs with mucolytic effect in the complex therapy of asthma exacerbation. Conclusion. Despite the fact that acetylcysteine and carbocysteine were significantly more often prescribed for more severe and pronounced asthma exacerbation a decrease in the relative and absolute risks of longer hospitalization was observed in patients taking carbocysteine
Evaluation of Substitution Enzyme Therapy of Exocrine Pancreatic Insufficiency of Pancreatic Gland in Patients with Diabetes Mellitus and Chronic Pancreatitis
Authors:   Uzhhorod National University, Medical Faculty. 3, Narodna Square, Uzhhorod, Transcarpathian region 88000, Ukraine, Sirchak Ye. S. , Barani V. Ye.
Published: December 2020

The study of the combined course of chronic pancreatitis and diabetes mellitus present a particular interest. The purpose of the study was to determine the effectiveness of correction of exocrine pancreatic insufficiency of the pancreas in patients with chronic pancreatitis and diabetes mellitus types 1 and 2 with using of different forms and doses of polyenzyme drugs. Material and methods. 126 patients with diabetes mellitus and chronic pancreatitis were examined. The patients were divided into 2 groups: 1 group included 62 patients with type 1 diabetes mellitus, and 2 group comprised 64 patients with type 2 diabetes. All surveyed patients underwent general clinical, anthropometric, instrumental and laboratory methods of investigation. Patients of both groups were divided into subgroups depending on the method of correction of exocrine pancreatic insufficiency, namely 1.1 and 2.1 subgroups received tableted polyenzyme preparation with minimal lipase activity of 10000 IU as enzyme therapy, and 1.2 and 2.2 subgroups received mini-tableted polyenzyme preparation with minimal lipase activity of 25000 IU. Results and discussion. The use of mini-tableted polyenzyme preparation with minimal lipase activity of 25000 IU according to the results of C13-mixed triglyceride and C13-amylase breath tests was an effective method for the correction of exocrine insufficiency of the pancreas in patients with chronic pancreatitis and diabetes mellitus types 1 and 2. We detected a statistically significant increase of the maximally concentration of 13CO2 between 150 and 210 minutes of the study (up to 9.2±0.4% 1.2 subgroup and up to 9.7±0.5% in patients 2.2 subgroup), as well as the total concentration of 13CO2 in at the end of 360 minutes of the study (up to 19.7±0.6% and up to 27.3±1.1%) according to the results of C13-mixed triglyceride breath tests, p<0,05. Conclusion. The use of a mini-tableted polyenzyme preparation with a minimum lipase activity of 25000 IU was a more effective method for correction of exocrine pancreatic insufficiency in patients with chronic pancreatitis and type 1 and 2 diabetes mellitus, than using a tableted polyenzyme preparation in a dose of 20000 IU per main meal. The study results showed that using C13-mixed triglyceride and C13-amylase breath test were highly informative methods for evaluating the effectiveness of enzyme replacement therapy in exocrine pancreatic insufficiency in patients with chronic pancreatitis and type 1 and 2 diabetes. The use of a mini-tablet polyenzyme drug in patients with chronic pancreatitis and type 1 and 2 diabetes mellitus is an effective means to normalize the manifestations of malabsorption in terms of α1-antitrypsin clearance
Effect of Cadmium Exposure on Male Fertility
Authors:   State Institution Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine. 9, Vernadsky St., Dnipro 49044, Ukraine, Onul N. M. , Biletska E. M. , Holovkova T. A.
Published: December 2020

Among the xenobiotics of diverse nature, heavy metals are especially dangerous for the human reproductive system in case of excessive intake. Cadmium, which is one of the most common toxic substances for the environment and production, can pose a potential threat to human health. An increasing amount of cadmium in the environmental objects and in nutrition is believed to be related to a poor semen quality. The purpose of the study was to determine the impact of cadmium on the reproductive potential of men who live in ecologically contrasting conditions. Material and methods. Clinical and hygienic assessment of the reproductive health was carried out among 2 experimental groups: the 1st group consisted of fertile men living in the city of Dnipro (62 respondents), the 2nd group included men with normal fertility living in the control city (37 respondents). To determine the cadmium concentration, venous blood samples and ejaculate were selected according to the standard methods. Biological samples were transferred to aliquots, frozen and stored at -20 ° C until analysis. The research was carried out using inversion voltammetry on the device AVA-2. Statistical processing of the results was carried out using statistical software packages of statistical analysis Statistica v.6.1 (StatsoftInc., США, licence NAJAR909E415822FA), Microsoft Excel. Results and discussion. Cadmium content in the blood and in the sperm of the fertile men of industrial city 1.3-5.8 times higher than the results of research in the control city and literature data. Differences between the cadmium content in the blood and semen of fertile men was shown to be unlikely, suggesting that the hematotesticular barrier is insufficient to protect the male reproductive organs from the toxic effects of the metal. The ejaculate in the fertile men of the studied cities is characterized by normosospermia and meets the standards. However in the residents of the industrial city the ejaculate quality indices were mostly at the lower level of the norm and were significantly worse than in the residents of the control city. Cadmium contained in male biosubstrates affect the hormonal status and quality of semen. Conclusion. Violations of spermatogenesis can serve as a rapidly-responding and reliable criterion for assessing the adaptation and maladaptation processes of men under the influence of xenobiotics of the environment, in particular cadmium. In this case, the markers of influence are the total number of sperm in the ejaculate, their concentration, mobility and the number of pathological forms, semen viscosity
The Maxillary Artery Definition According to CBCT Data in Patients with Chronic Maxillary Sinusitis
Authors:   Belarusian State Medical University. 83, Dzerzhinski Ave., Minsk 220116, Republic of Belarus, Pohodenko-Chudakova I. O. , Maksimovich E. V. , Hosseinpour A. M.
Published: December 2020

The number of maxillary sinusitis is significant in the structure of inflammatory diseases in an outpatient maxilla-facial surgery and they are one of the chief reasons for the patients’ hospitalization. The anatomy of maxillary sinus with 3D Computer tomography scan should be included in appropriate presurgical treatment planning. The purpose of the study was to determine the visualization and diameter of the maxillary artery in according analyzing of Cone bean computer tomography data of patients, to identify the relationship between the presence of chronic maxillary sinusitis and the visualization of the maxillary artery and its diameter. Material and methods. The data of 44 Cone bean computer tomography results was analyzed for 24 patients with chronic maxillary sinusitis of odontogenic origin (it was observation group 1, included 48 sinuses), 20 patients were without pathological changes in the maxillary sinus (it was comparison group 2, included 40 sinuses). All the Cone bean computer tomographies randomly selected by patients who visited dental outpatient clinics of Minsk city, the Republic of Belarus during the period from 2018 to 2020 and were analyzed by GALILEOS program. Results and discussion. The analysis revealed that maxillary artery was not detected in 25.0% (12) patients of group 1, while in group 2 it was not detected in 5.0% (2) patients. When determining the diameter of the maxillary artery, we found that in group 1 patients, the artery diameter 0.1-0.99 mm was determined in 91.7% (33) cases, and in 92.2% (35) of group 2 patients; the diameter of the maxillary artery 1.0 mm or more in group 1 patients was determined in 8.3% (3) of observations, and in 7.8% (3) of group 2 patients Different types of the maxillary arteries localization were revealed. Conclusion. The study results showed that in patients of group 1 with the presence of chronic maxillary sinusitis, the maxillary artery was not visualized 5 times more often than in patients of group 2 (comparison group), which may indicate to deeper ischemic changes in the maxillary tissues of patients with chronic maxillary sinusitis. There was no significant difference in the diameter of the maxillary arteries in groups 1 and 2. The study will be continued