bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk
Authors: Ye Yuanqing , Wang Kenneth K. , Gu Jian , Yang Hushan , Lin Jie , Ajani Jaffer A. , Wu Xifeng
Published: November 2008

MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related genes may increase the risk for esophageal cancer, we assessed the associations between esophageal cancer risk and 41 potentially functional single nucleotide polymorphisms (SNP) in 26 miRNA-related genes in a case-control study of 346 Caucasian esophageal cancer patients (85.5% with esophageal adenocarcinoma) and 346 frequency-matched (age, gender, and ethnicity) controls. Seven SNPs were significantly associated with esophageal cancer risk. The most notable finding was that the SNP rs6505162, which is located in the pre-mir423 region, was associated with a per-allele odds ratio of 0.64 [95% confidence interval (95% CI), 0.51-0.80; P for trend < 0.0001]. This association remained significant after we corrected for multiple comparisons. A common haplotype of the GEMIN4 gene was associated with a significantly reduced risk of esophageal cancer (odds ratio, 0.65; 95% CI, 0.42-0.99). We did a combined unfavorable genotype analysis to further evaluate the cumulative effects of the promising (risk associated) SNPs. In comparison with the low-risk group (fewer than three unfavorable genotypes), the medium-risk group (three unfavorable genotypes) had a 2.00-fold (95% CI, 1.31-3.08) increased risk and the high-risk group (more than three unfavorable genotypes) had a 3.14-fold (95% CI, 2.03-4.85) increased risk (P for trend < 0.0001). Results for the risk of esophageal adenocarcinoma were similar to the overall risk results. The present study provides the first evidence that miRNAs may affect esophageal cancer risk in general and that specific genetic variants in miRNA-related genes may affect esophageal cancer risk individually and jointly.
Urinary Excretion of Pentose Phosphate Pathway-Associated Polyols in Early Postnatal Life
Authors: Koy Anne , Waldhaus Anne , Hammen Hans-Werner , Wendel Udo , Mayatepek Ertan , Schadewaldt Peter
Published: November 2008

Background: Two new inborn errors in the pentose phosphate pathway have been described: ribose-5-isomerase deficiency and transaldolase deficiency. These defects are characterized by accumulation of specific polyols in body fluids. Little is known about human polyol metabolism, but there are indications for a physiological role primarily during early development. Objectives: The objective of this study was to evaluate the urinary excretion of polyols in neonates with special interest on a possible impact of the grade of maturity. For comparison, urinary polyol excretion in older children was also studied. Methods: Urine samples of 40 neonates born between gestational week 25 and 41 were analyzed for the excretion of pentose phosphate pathway-associated polyols (erythritol, D-arabitol, ribitol, xylitol). These metabolites were also quantified in urine obtained from 77 children aged 4 weeks to 10 years. Results: The results show high urinary polyol excretions after birth independent of the week of gestation. During the first months of life, the concentrations decreased exponentially and reached a fairly stable steady state thereafter. Conclusions: Urinary excretion of polyols shows an age dependency with highest concentrations postnatally independent of the grade of maturity. These findings suggest a possible connection between the formation of pentose phosphate pathway-associated polyols and fetal development.
A New and Practical Aspartate Aminotransferase Test in Vaginal Washing Fluid for the Detection of Preterm Premature Rupture of Membranes
Authors: Kale Ebru , Kuyumcuoğlu Umur , Kale Ahmet , Güzel Ali İrfan , Canoruc Naime
Published: November 2008

Objectives: To determine whether measurement of aspartate aminotransferase (Ast) and alanine aminotransferase (Alt) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (PPROM). Study Design: The PPROM group and normal pregnancy group consisted of 36 and 48 pregnant patients between 26 and 36 weeks’ gestation, respectively. Vaginal fluid Ast and Alt levels were measured in both groups. Results: Vaginal fluid Alt level was not statistically significant in the PPROM group as compared with the control group (p = 0.064). Vaginal Ast level was statistically significant in the PPROM (14.4 ± 17.46 U/l) group as compared with the control group (3.08 ± 7.8 U/l; p = 0.001). The optimal cutoff value of 3 IU/l for Ast gave a sensitivity level of 91% at a specificity of 83%, with positive and negative predictive values of 80 and 93%, respectively. Conclusion: Ast measurement from vaginal washing fluid appears to be a useful marker for the detection of PPROM.
Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice
Authors: Ozmen Laurence , Albientz Anita , Czech Christian , Jacobsen Helmut
Published: November 2008

Background: Alzheimer’s disease is the most common cause of dementia occurring in the elderly. The identification of the genetic factors in the familial forms of the disease enabled the generation of transgenic animals which reproduce an essential part of its pathology. Various lines of transgenic mice expressing human wild-type or mutated APP have been reported. The phenotype expressed in these mice varies according to the transgene itself, the promoter used for its expression, and the level of expression achieved in the brain, but is also determined by the genetic background of the mice. Methods: We analyzed the variability in the amyloid load by ELISA and the levels of huAPP transcripts by quantitative PCR in our PS2APP double-transgenic mice when expressed in a mixed C57Bl/6, DBA/2 background. Results: In 12-month-old PS2APP double-transgenic mice, the amount of cerebral amyloid deposits is directly correlated with the levels of the huAPP transgenic transcript. Furthermore, a reduction in human APP transcripts by 50% leads to a complete absence of cerebral deposits at the age of 12 months. Conclusion: Our results demonstrate that a 2-fold reduction in APP expression can result in a profound decrease in brain pathology.
Beauty and the Street: 72 Hours in Union Square, NYC
Authors: Amaris Lián
Published: November 2008

Given the media frenzy over Hillary Clinton's unsuccessful presidential bid, and the ensuing questions about the state of feminism, it seems a serendipitous moment to feature two pieces—written by the women who conceived and performed them—that offer very different but complementary takes on agency, identity, and the conflation of the public and private as one's body becomes the locus of the gaze. Petra Kuppers's dramaturgical meditation on her experiences as part of Tiresias, a disability culture performance project, investigates erotics, change, mythology, and identity. A collaboration between photographers, writers, and dancers, the project, occurring over six months in 2007, posits the body as the site at which myth might be reshaped and movement might become poetry. Lián Amaris critically analyzes her feminist public performance event Fashionably Late for the Relationship, which took place over three days in July 2007 on the Union Square traffic island in New York City. Informed by Judith Butler's citational production of gender, the piece focused on exposing and critiquing the marked visibility of gender construction and maintenance within an extreme performance paradigm.
Divine Anonymities: On Transascendence and Transdescendence in the Works of Levinas, Celan, and Lispector
Authors: Ballan Joseph
Published: November 2008

Those points at which Emmanuel Levinas's later work touches on the question of God express a profound ambiguity. Here it is often the case that theism becomes indistinguishable from atheism, ethics is shown to be indistinguishable from religion and, to cite two important concepts invented by Levinas, il y a (lit., “there is;” denotes bare, senseless material existence) becomes indistinguishable from illeité (lit., “it-ness;” denotes the absolute distance or anonymity of God). While Levinas insists upon a measure of ambiguity or enigma in all truthful religious discourse, these series of ambiguities are often covered over by Levinas's ethical project as soon as they appear. With the aid of two deeply philosophical writers in whose work we find literary analogues of the ambiguities thematized in Levinas—the poet Paul Celan and the novelist Clarice Lispector—this paper offers a critique of Levinas's thin, often moralistic, concepts of alterity and transcendence. The critique proceeds by showing how Celan and Lispector demonstrate the consequences of thinking the anonymity of God and the corresponding undecidability of the most-high and the most-low (i.e., transascendence and transdescendence) to its logical conclusion. In the process, Celan and Lispector emerge as original religious thinkers in their own right, not merely as counterweights to Levinas.
Breeding Racism: The Imperial Battlefields of the “German” Shepherd Dog
Authors: Skabelund Aaron
Published: November 2008

During the first half of the twentieth century, the Shepherd Dog came to be strongly identified with Imperial and Nazi Germany, as well as with many other masters in the colonial world. Through its transnational diffusion after World War I, the breed became a pervasive symbol of imperial aggression and racist exploitation. The 1930s Japanese empire subtly Japanized the dogs who became an icon of the Imperial Army. How could a cultural construct so closely associated with Germany come to represent many different colonial regimes? Using Imperial Japan as a case study, this paper argues that this symbolic pliability is a derivative of the high functionality, wide adaptation, and conspicuous nature of the Shepherd Dog as protector, deterrent, and enforcer of social control. As a visible intermediary in hierarchal relationships between different human groups, the Shepherd Dog became a powerful metaphor of Nazi and colonial memories throughout much of the world.
Enforcing a Turning Point and Imposing a Deal: An Analysis of the Darfur Abuja Negotiations of 2006
Authors: Brooks Sean
Published: November 2008

Low expectations and international impatience forced the African Union to shift from a classical integrative approach to negotiations to “deadline diplomacy” during the final months of the Abuja talks between the Sudanese government and the Darfur rebel movements. As a result, the AU mediators – who had served as communicators and formulators – assumed the responsibility of manipulators. This transition scuttled plans for gradually arriving at the implementing details for a formula. Instead, acquiescence to power served as the chief reason for the signature of one of the movements, while the mediators showed disinterest and inflexibility in reigning in the other two movements that required a package of additional threats and inducements. Important lessons regarding the credibility of deadlines, the appropriateness of the formula, the necessity of ownership, inclusivity/exclusivity of the talks, and sufficient support for the movements in the prenegotiation and diagnosis phases can be drawn from the Abuja process.
Association les Témoins de Jéhovah versus France The Jurisprudence of the European Court of Human Rights on Religious Activities and Taxation Issues
Authors: Garay Alain
Published: November 2008

According to the jurisprudence of the judicial bodies of the Council of Europe, association and financial laws has considerable influence on the fiscal status of religious activities. To a certain extent, it conditions the choice of statutes and juridical structures by religious institutions. At the national level, the tax system in consequence submits the activities in question to particular regulations which have led many religious institutions to opt for elaborate fiscal and legal arrangements, compartmentalized into distinct sectors or into separate structures. Such is the case with the activities of the religious economy sector: publishing, agricultural and vinicultural production, tourism services which require recourse to complex legal and fiscal organizational schemas. A series of examples related to the taxation of religious bodies can demonstrate the extent of some contradictions: – differences of treatment by the national Administrations in refusing tax exemptions or denying religious status to certain movements; – recourse to fiscal controls or audits as a “tactical weapon”. In many countries the debate continues today due to changes in the financial regulations affecting religious activities and discriminatory applications of the principle of equality of religions before the law. This debate is based on the never-ending questions about criteria relying on the historical presence, representative nature and social utility of religions, issues that have been the object of legal distinctions.
Average Predictability Time. Part I: Theory
Authors: DelSole Timothy , Tippett Michael K.
Published: November 2008

This paper introduces the average predictability time (APT) for characterizing the overall predictability of a system. APT is the integral of a predictability measure over all lead times. The underlying predictability measure is based on the Mahalanobis metric, which is invariant to linear transformation of the prediction variables and hence gives results that are independent of the (arbitrary) basis set used to represent the state. The APT is superior to some integral time scales used to characterize the time scale of a random process because the latter vanishes in situations when it should not, whereas the APT converges to reasonable values. The APT also can be written in terms of the power spectrum, thereby clarifying the connection between predictability and the power spectrum. In essence, predictability is related to the width of spectral peaks, with strong, narrow peaks associated with high predictability and nearly flat spectra associated with low predictability. Closed form expressions for the APT for linear stochastic models are derived. For a given dynamical operator, the stochastic forcing that minimizes APT is one that allows transformation of the original stochastic model into a set of uncoupled, independent stochastic models. Loosely speaking, coupling enhances predictability. A rigorous upper bound on the predictability of linear stochastic models is derived, which clarifies the connection between predictability at short and long lead times, as well as the choice of norm for measuring error growth. Surprisingly, APT can itself be interpreted as the “total variance” of an alternative stochastic model, which means that generalized stability theory and dynamical systems theory can be used to understand APT. The APT can be decomposed into an uncorrelated set of components that maximize predictability time, analogous to the way principle component analysis decomposes variance. Part II of this paper develops a practical method for performing this decomposition and applies it to meteorological data.
Tropical Intraseasonal Variability in the MRI-20km60L AGCM*
Authors: Liu Ping , Kajikawa Yoshiyuki , Wang Bin , Kitoh Akio , Yasunari Tetsuzo , Li Tim , Annamalai H. , Fu Xiouhua , Kikuchi Kazuyoshi , Mizuta Ryo , Rajendran Kavirajan , Waliser Duane E. , Kim Daehyun
Published: November 2008

This study documents the detailed characteristics of the tropical intraseasonal variability (TISV) in the MRI-20km60L AGCM that uses a variant of the Arakawa–Schubert cumulus parameterization. Mean states, power spectra, propagation features, leading EOF modes, horizontal and vertical structures, and seasonality associated with the TISV are analyzed. Results show that the model reproduces the mean states in winds realistically and in convection comparable to that of the observations. However, the simulated TISV is less realistic. It shows low amplitudes in convection and low-level winds in the 30–60-day band. Filtered anomalies have standing structures. Power spectra and lag correlation of the signals do not propagate dominantly either in the eastward direction during boreal winter or in the northward direction during boreal summer. A combined EOF (CEOF) analysis shows that winds and convection have a loose coupling that cannot sustain the simulated TISV as realistically as that observed. In the composited mature phase of the simulated MJO, the low-level convergence does not lead convection clearly so that the moisture anomalies do not tilt westward in the vertical, indicating that the low-level convergence does not favor the eastward propagation. The less realistic TISV suggests that the representation of cumulus convection needs to be improved in this model.
Evaluating the “Rich-Get-Richer” Mechanism in Tropical Precipitation Change under Global Warming
Authors: Chou Chia , Neelin J. David , Chen Chao-An , Tu Jien-Yi
Published: November 2008

Examining tropical regional precipitation anomalies under global warming in 10 coupled global climate models, several mechanisms are consistently found. The tendency of rainfall to increase in convergence zones with large climatological precipitation and to decrease in subsidence regions—the rich-get-richer mechanism—has previously been examined in different approximations by Chou and Neelin, and Held and Soden. The effect of increased moisture transported by the mean circulation (the “direct moisture effect” or “thermodynamic component” in respective terminology) is relatively robust, while dynamic feedback is poorly understood and differs among models. The argument outlined states that the thermodynamic component should be a good approximation for large-scale averages; this is confirmed for averages across convection zones and descent regions, respectively. Within the convergence zones, however, dynamic feedback can substantially increase or decrease precipitation anomalies. Regions of negative precipitation anomalies within the convergence zones are associated with local weakening of ascent, and some of these exhibit horizontal dry advection associated with the “upped-ante” mechanism. Regions of increased ascent have strong positive precipitation anomalies enhanced by moisture convergence. This dynamic feedback is consistent with reduced gross moist stability due to increased moisture not being entirely compensated by effects of tropospheric warming and a vertical extent of convection. Regions of reduced ascent with positive precipitation anomalies are on average associated with changes in the vertical structure of vertical velocity, which extends to higher levels. This yields an increase in the gross moist stability that opposes ascent. The reductions in ascent associated with gross moist stability and upped-ante effects, respectively, combine to yield reduced ascent averaged across the convergence zones. Over climatological subsidence regions, positive precipitation anomalies can be associated with a convergence zone shift induced locally by anomalous heat flux from the ocean. Negative precipitation anomalies have a contribution from the thermodynamic component but can be enhanced or reduced by changes in the vertical velocity. Regions of enhanced subsidence are associated with an increased outgoing longwave radiation or horizontal cold convection. Reductions of subsidence are associated with changes of the vertical profile of vertical velocity, increasing gross moist stability.
An Analysis of Moisture Fluxes into the Gulf of California
Authors: Wu Man-Li C. , Schubert Siegfried D. , Suarez Max J. , Huang Norden E.
Published: November 2008

This study examines the nature of episodes of enhanced warm-season moisture flux into the Gulf of California. Both spatial structure and primary time scales of the fluxes are examined using the 40-yr ECMWF Re-Analysis data for the period 1980–2001. The analysis approach consists of a compositing technique that is keyed on the low-level moisture fluxes into the Gulf of California. The results show that the fluxes have a rich spectrum of temporal variability, with periods of enhanced transport over the gulf linked to African easterly waves on subweekly (3–8 day) time scales, the Madden–Julian oscillation (MJO) at intraseasonal time scales (20–90 day), and intermediate (10–15 day) time-scale disturbances that appear to originate primarily in the Caribbean Sea–western Atlantic Ocean.

In the case of the MJO, enhanced low-level westerlies and large-scale rising motion provide an environment that favors large-scale cyclonic development near the west coast of Central America that, over the course of about 2 weeks, expands northward along the coast eventually reaching the mouth of the Gulf of California where it acts to enhance the southerly moisture flux in that region. On a larger scale, the development includes a northward shift in the eastern Pacific ITCZ, enhanced precipitation over much of Mexico and the southwestern United States, and enhanced southerly/southeasterly fluxes from the Gulf of Mexico into Mexico and the southwestern and central United States. In the case of the easterly waves, the systems that reach Mexico appear to redevelop/reorganize on the Pacific coast and then move rapidly to the northwest to contribute to the moisture flux into the Gulf of California. The most intense fluxes into the gulf on these time scales appear to be synchronized with a midlatitude short-wave trough over the U.S. West Coast and enhanced low-level southerly fluxes over the U.S. Great Plains. The intermediate (10–15 day) time-scale systems have zonal wavelengths roughly twice that of the easterly waves, and their initiation appears to be linked to an extratropical U.S. East Coast ridge and associated northeasterly winds that extend well into the Caribbean Sea during their development phase. The short (3–8 day) and, to a lesser extent, the intermediate (10–15 day) time-scale fluxes tend to be enhanced when the convectively active phase of the MJO is situated over the Americas.
Why the Western Pacific Subtropical High Has Extended Westward since the Late 1970s
Authors: Zhou Tianjun , Yu Rucong , Zhang Jie , Drange Helge , Cassou Christophe , Deser Clara , Hodson Daniel L. R. , Sanchez-Gomez Emilia , Li Jian , Keenlyside Noel , Xin Xiaoge , Okumura Yuko
Published: November 2008

The western Pacific subtropical high (WPSH) is closely related to Asian climate. Previous examination of changes in the WPSH found a westward extension since the late 1970s, which has contributed to the interdecadal transition of East Asian climate. The reason for the westward extension is unknown, however. The present study suggests that this significant change of WPSH is partly due to the atmosphere’s response to the observed Indian Ocean–western Pacific (IWP) warming. Coordinated by a European Union’s Sixth Framework Programme, Understanding the Dynamics of the Coupled Climate System (DYNAMITE), five AGCMs were forced by identical idealized sea surface temperature patterns representative of the IWP warming and cooling. The results of these numerical experiments suggest that the negative heating in the central and eastern tropical Pacific and increased convective heating in the equatorial Indian Ocean/Maritime Continent associated with IWP warming are in favor of the westward extension of WPSH. The SST changes in IWP influences the Walker circulation, with a subsequent reduction of convections in the tropical central and eastern Pacific, which then forces an ENSO/Gill-type response that modulates the WPSH. The monsoon diabatic heating mechanism proposed by Rodwell and Hoskins plays a secondary reinforcing role in the westward extension of WPSH. The low-level equatorial flank of WPSH is interpreted as a Kelvin response to monsoon condensational heating, while the intensified poleward flow along the western flank of WPSH is in accord with Sverdrup vorticity balance. The IWP warming has led to an expansion of the South Asian high in the upper troposphere, as seen in the reanalysis.
Contributions of Indian Ocean and Monsoon Biases to the Excessive Biennial ENSO in CCSM3
Authors: Yu Jin-Yi , Sun Fengpeng , Kao Hsun-Ying
Published: November 2008

The Community Climate System Model, version 3 (CCSM3), is known to produce many aspects of El Niño–Southern Oscillation (ENSO) realistically, but the simulated ENSO exhibits an overly strong biennial periodicity. Hypotheses on the cause of this excessive biennial tendency have thus far focused primarily on the model’s biases within the tropical Pacific. This study conducts CCSM3 experiments to show that the model’s biases in simulating the Indian Ocean mean sea surface temperatures (SSTs) and the Indian and Australian monsoon variability also contribute to the biennial ENSO tendency. Two CCSM3 simulations are contrasted: a control run that includes global ocean–atmosphere coupling and an experiment in which the air–sea coupling in the tropical Indian Ocean is turned off by replacing simulated SSTs with an observed monthly climatology. The decoupling experiment removes CCSM3’s warm bias in the tropical Indian Ocean and reduces the biennial variability in Indian and Australian monsoons by about 40% and 60%, respectively. The excessive biennial ENSO is found to reduce dramatically by about 75% in the decoupled experiment. It is shown that the biennial monsoon variability in CCSM3 excites an anomalous surface wind pattern in the western Pacific that projects well into the wind pattern associated with the onset phase of the simulated biennial ENSO. Therefore, the biennial monsoon variability is very effective in exciting biennial ENSO variability in CCSM3. The warm SST bias in the tropical Indian Ocean also increases ENSO variability by inducing stronger mean surface easterlies along the equatorial Pacific, which strengthen the Pacific ocean–atmosphere coupling and enhance the ENSO intensity.
Influence of Moist Physics and Norms on Singular Vectors for a Tropical Cyclone
Authors: Kim Hyun Mee , Jung Byoung-Joo
Published: November 2008

In this study, the structures and growth rates of singular vectors (SVs) for Typhoon Usagi were investigated using different moist physics and norms. The fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5) and its tangent linear and adjoint models with a Lanczos algorithm were used to calculate SVs over a 36-h period. The moist physics used for linear (i.e., tangent linear and adjoint model) integrations is large-scale precipitation, and the norms used are dry and moist total energy (TE) norms. Overall, moist physics in linear integrations and a moist TE norm increase the growth rates of SVs and cause smaller horizontal structures and vertical distributions closer to the lower boundary. With a dry TE norm, the SV energy distributions show similar (dissimilar) large- (small-) scale horizontal SV structures for experiments, regardless of physics. The SVs with moist linear physics and a moist TE norm have maximum horizontal energy structures near the typhoon center. With a small weighting on the moisture term in the moist TE norm, both the remote and nearby influences on the TC are indicated by the horizontal SV energy distributions. The kinetic energy shows the largest contributions to the vertical SV TE distributions in most of the experiments, except for the largest moisture (potential energy) contributions to the SV TE at the final (initial) time in the moist TE norm (dry and weighted moist TE norms at uppermost levels). In contrast, the SV vorticity distributions show more consistent structures among experiments with different linear physics and norms, implying that, in terms of the rotational component of the wind field, the SVs are not sensitive to the choice of moist physics and norms. Given large-scale precipitation as the linear moist physics, the SV energy structures and growth rate with a moist TE norm show the largest difference when compared with those with other norms.
Torbangun (Coleus amboinicus Lour): A Bataknese Traditional Cuisine Perceived as Lactagogue by Bataknese Lactating Women in Simalungun, North Sumatera, Indonesia
Authors: Damanik Rizal
Published: November 2008

Torbangun (Coleus amboinicus Lour ) has been used as a breast milk stimulant (a lactagogue) by Bataknese people in Indonesia for hundreds of years. However, the traditional use of torbangun is not well documented, and scientific evidence is limited to establish coleus as a lactagogue. This Focus Group Discussion (FGD) study was conducted to gather information regarding the practice and cultural beliefs related to the traditional use of torbangun as a lactagogue. The main findings of this investigation were: (1) torbangun, which is considered nourishing, is usually given to the mother for one month after giving birth in order to restore her state of balance; (2) in the Bataknese culture, torbangun is perceived to serve several purposes which include enhancing breast milk production and acting as a uterine cleansing agent; and (3) the tradition has been practiced for hundreds of years, and its adherence is still strong. J Hum Lact. 25(1):64-72.
The State and the Creation of an Environment for the Growing of Trust
Authors: Herreros Francisco
Published: November 2008

There is a growing interest in the literature on trust and social capital in the analysis of the role of the State in the creation and destruction of trust. According to some authors, the intervention of the State crowds out trust instead of fostering it. In this article, the author shows that the intervention of the State as a third-party enforcer of agreements does not crowd out expectations of trust, but it does not create trust either. However, it is further shown that the absence or inefficacy of the State does destroy trust. This last idea is illustrated with a classical case in the social capital literature: Southern Italy in the modern period.
Passage Meditation Improves Caregiving Self-efficacy among Health Professionals
Authors: Oman Doug , Richards T. Anne , Hedberg John , Thoresen Carl E.
Published: November 2008

Relational caregiving skills remain seldom studied in health professionals. We evaluated effects on health professional relational caregiving self-efficacy from an eight-week, 16-hour training in self-management tools. Physicians, nurses, chaplains, and other health professionals were randomized after pretest to treatment ( n = 30) or waiting list ( n = 31). Training used a previously researched program of Easwaran (1991/1978) derived from spiritual wisdom traditions. Changes were measured using a 34-item caregiving self-efficacy scale. Positive effects were observed at posttest, eight- and 19-week follow-up ( ds = .38, .47, .37, all ps < .05), and were mediated by adherence to practices and stress reductions ( p < .05), findings also obtained in qualitative interviews ( n = 24). Evidence suggests this program enhances health professional caregiving self-efficacy, and may merit inclusion in training curricula.
Reasons Given by Elderly Men and Women for Not Owning a Pet, and the Implications for Clinical Practice and Research
Authors: Chur-Hansen Anna , Winefield Helen , Beckwith Melinda
Published: November 2008

There is inadequate understanding about why people might not own pets. This qualitative study asked eight elderly women and men to discuss why they do not have a pet, whether pets were deemed beneficial to health, and whether they had plans for future pet ownership. Reasons for not owning a pet were Emotional or Pragmatic. Pragmatic reasons were categorized as relating to Convenience, Negative aspects of companion animals and Competing demands on time or energy. Participants expressed mixed feelings in their plans for future pet ownership. Clinical and research implications of these findings are discussed.
The Association of Perceived Partner-related Social Support with Self-reported Outcomes in Women Post-mastectomy
Authors: Kudel Ian , Edwards Robert , Raja Srinivasa , Haythornthwaite Jennifer , Heinberg Leslie J.
Published: November 2008

Marital satisfaction is an important indicator of adaptation in patients with cancer; however, its relationship to medium-to-long-term health-related outcomes is less well understood. Married women ( N = 152) at least six months post-mastectomy were surveyed to determine whether marital satisfaction predicted non-weight-related body image distress (BID), pain impact, and mood, or whether the directionality of this association operated in reverse. Structural equation modeling indicated that the model predicting medium-to-long-term health-related outcomes from satisfaction better fit the data and that time influences mood.
Morality and Accountability in a Commercial Weight Management Group
Authors: Mycroft Hazel
Published: November 2008

Talk about food and eating behaviours invariably contains some reference to morality or accountability. However, there are very few studies that focus upon `mundane dieting'. This research addresses this by examining 37.83 hours of naturally occurring interaction of how women construct and orient to food and their dieting practices within an everyday type setting. Group members produced accounts with reference to a moral evaluation, such as blame or culpability. It became apparent that both the group leaders and group members could not orient to their behaviour or food without reference to a moral or accountable framework. Implications for health promotion literature and programmes, along with weight management groups are considered.
Native American Elders' Health Congruence
Authors: Ruthig Joelle C. , Allery Alan
Published: November 2008

Addressing the need to explore how Native American (NA) elders' subjective health (SH) compares to their objective health (OH; chronic disease conditions), we examined whether: congruence between 8191 NA elders' SH and OH parallels that of non-NA elders; health optimism (SH > OH) is protective and health pessimism (SH < OH), is detrimental; and whether gender moderates links between health congruence and health-related outcomes. Results comparing health optimists and pessimists to realists in functioning, hospitalizations, and social engagement showed optimists experienced better outcomes; pessimists had poorer outcomes; the role of health congruence differed by gender. Findings suggest implications for improving health-related outcomes among NA elders.
Regulation and rupture
Authors: Renold Emma , Ringrose Jessica
Published: November 2008

Recent feminist theorizing has pointed to a `resurgent patriarchy' within neo-liberal postfeminist times, which re-orders and restabilizes the heterosexual matrix through a politics of `postfeminist masquerade' demanded of girls and women (McRobbie). This paper seeks to complicate this thesis, exploring the regulation and rupture of Butler's `heterosexual matrix' as a complex performative politics through which girls' conflictual relationships with themselves, and other girls and boys are staged and through which dominant versions of tweenage and teenage femininity are reinscribed but also reworked, in race and class specific ways. Drawing on Deleuze and Guattari's powerful conceptual repertoire for disrupting Oedipal logics in Anti-Oedipus, we offer a `molecular mapping', illustrating cracks and ruptures in what is a porous heterosexual matrix, exploring a rhythm of `deterritorializations' and `reterritorializations' of the normative in our respective ethnographic and narrative interviews with girls. We also trace more sustained ruptures of heteronormative femininity drawing upon Deleuze and Guattari's notion of `lines of flight' and Braidotti's concept of `alternative figuration'. We argue ruptures and alternative figurations are not constitutive of total `molar' resistance to norms, but are significant spaces of doing girl differently and crucial to map if we are to perceive the malleability and multiplicity of contemporary girl subjectivities, which exceed heteronormative femininity and phallogocentric desire.
Globalization, Conflict and Mental Health
Authors: Piachaud Jack
Published: November 2008

Violent conflict for political ends, including war and civil war, is a major cause of mental ill health and although there are different approaches and ways to understand this relationship some consensus is emerging on the psychological, social and cross sector responses to post conflict situations. Globalization has changed the relationships of nation states, corporations and international organizations creating different patterns of political violence and different ways to organize the responses. Victims, weapons and humanitarian aid are considered within a public mental health framework, describing the consequences of war and other forms of political violence. Secondary and primary levels of intervention in public mental health consider the monitoring, preparation for and prevention of political violence, taking the new sciences of human relationships as a basis to look at international relationships. The need to re-establish a reformed United Nations at the centre of global decision making and to increase the global expenditure on peace making are two conclusions from this analysis.
Potential Predictors of Motor and Functional Outcomes After Distributed Constraint-Induced Therapy for Patients With Stroke
Authors: Lin Keh-chung , Huang Yan-hua , Hsieh Yu-wei , Wu Ching-yi
Published: November 2008

Background. Selection of patients who are most and least likely to benefit from constraint-induced therapy (CIT) for the upper extremity is uncertain. Objective. This study investigated demographic and clinical characteristics that may predict outcomes for a distributed form of CIT. Methods. A group of 57 patients were treated with distributed CIT, and 7 potential predictors were identified, including age, sex, side of stroke, time since stroke, spasticity, neurologic status, and movement performance of the distal part of the upper extremity. Treatment outcome was assessed in terms of motor performance, perceived functional ability of the affected hand, and functional performance of daily activities, measured by Fugl-Meyer Assessment (FMA), Motor Activity Log (MAL), and Functional Independence Measure (FIM), respectively. Results. Motor ability of the distal part of the upper extremity and time since stroke were significantly predictive of outcomes on the FMA (adjusted R2 = 0.18, P = .002) and the MAL subtest quality of movement (adjusted R 2 = 0.43, P < .0001). Motor ability and age were significant predictors of amount of use measured by the MAL (adjusted R2 = 0.20, P = .001). None of the variables exhibited a predictive relationship with the FIM. Conclusions. The best predictor for motor outcomes after distributed CIT was greater motor ability of the distal part of the upper extremity, which is consistent with the presence of residual motor pathways that may respond to training. The FMA may be of value in stratifying patients for their likelihood to benefit from distributed CIT protocols.
NemaPath: online exploration of KEGG-based metabolic pathways for nematodes
Authors: Wylie Todd , Martin John , Abubucker Sahar , Yin Yong , Messina David , Wang Zhengyuan , McCarter James P , Mitreva Makedonka
Published: November 2008

Background

Nematode.net http://www.nematode.net is a web-accessible resource for investigating gene sequences from parasitic and free-living nematode genomes. Beyond the well-characterized model nematode C. elegans, over 500,000 expressed sequence tags (ESTs) and nearly 600,000 genome survey sequences (GSSs) have been generated from 36 nematode species as part of the Parasitic Nematode Genomics Program undertaken by the Genome Center at Washington University School of Medicine. However, these sequencing data are not present in most publicly available protein databases, which only include sequences in Swiss-Prot. Swiss-Prot, in turn, relies on GenBank/Embl/DDJP for predicted proteins from complete genomes or full-length proteins.

Description

Here we present the NemaPath pathway server, a web-based pathway-level visualization tool for navigating putative metabolic pathways for over 30 nematode species, including 27 parasites. The NemaPath approach consists of two parts: 1) a backend tool to align and evaluate nematode genomic sequences (curated EST contigs) against the annotated Kyoto Encyclopedia of Genes and Genomes (KEGG) protein database; 2) a web viewing application that displays annotated KEGG pathway maps based on desired confidence levels of primary sequence similarity as defined by a user. NemaPath also provides cross-referenced access to nematode genome information provided by other tools available on Nematode.net, including: detailed NemaGene EST cluster information; putative translations; GBrowse EST cluster views; links from nematode data to external databases for corresponding synonymous C. elegans counterparts, subject matches in KEGG's gene database, and also KEGG Ontology (KO) identification.

Conclusion

The NemaPath server hosts metabolic pathway mappings for 30 nematode species and is available on the World Wide Web at http://nematode.net/cgi-bin/keggview.cgi. The nematode source sequences used for the metabolic pathway mappings are available via FTP http://www.nematode.net/FTP/index.php, as provided by the Genome Center at Washington University School of Medicine.
Identification of human thioredoxin as a novel IFN-gamma-induced factor: Mechanism of induction and its role in cytokine production
Authors: Kim Seol-Hee , Oh Jiyoung , Choi Ja-Young , Jang Ji-Young , Kang Myoung-Wha , Lee Choong-Eun
Published: November 2008

Background

IFN-γ is a multifunctional peptide with a potent immune defense function which is also known as a prototypic Th1 cytokine. While screening for genes differentially expressed by Th1 and Th2 cytokines, human thioredoxin was identified as a novel target gene induced by IFN-γ. The mechanism by which thioredoxin is induced by IFN-γ and the signaling pathways involved in its induction were analyzed. In addition, the effects of thioredoxin on immune cell survival and cytokine production were examined by thioredoxin over-expression and recombinant thioredoxin treatment.

Results

Human thioredoxin was selectively induced by IFN-γ in monocytic and T cell lines. In monocytic cells, the induction of thioredoxin gene expression by IFN-γ was dose-dependent, and both the mRNA and protein levels were increased by 2~3 fold within 4 to 24 h hours of IFN-γ treatment. The thioredoxin induction by IFN-γ was insensitive to cycloheximide treatment, suggesting that it is a primary response gene induced by IFN-γ. Subsequent analysis of the signaling pathways indicated that the Jak/Stat, Akt, and Erk pathways play a role in IFN-γ signaling that leads to thioredoxin gene expression. Thioredoxin was induced by oxidative or radiation stresses, and it protected the immune cells from apoptosis by reducing the levels of reactive oxygen species. Furthermore, thioredoxin modulated the oxidant-induced cytokine balance toward Th1 by counter-regulating the production of IL-4 and IFN-γ in T cells.

Conclusion

These data suggest that thioredoxin is an IFN-γ-induced factor that may play a role in developing Th1 immunity and in the maintenance of immune homeostasis upon infection, radiation, and oxidative stress.
LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs)
Authors: Wei Tiandi , Gong Jing , Jamitzky Ferdinand , Heckl Wolfgang M , Stark Robert W , Rössle Shaila C
Published: November 2008

Background

Leucine-rich repeats (LRRs) are present in more than 6000 proteins. They are found in organisms ranging from viruses to eukaryotes and play an important role in protein-ligand interactions. To date, more than one hundred crystal structures of LRR containing proteins have been determined. This knowledge has increased our ability to use the crystal structures as templates to model LRR proteins with unknown structures. Since the individual three-dimensional LRR structures are not directly available from the established databases and since there are only a few detailed annotations for them, a conformational LRR database useful for homology modeling of LRR proteins is desirable.

Description

We developed LRRML, a conformational database and an extensible markup language (XML) description of LRRs. The release 0.2 contains 1261 individual LRR structures, which were identified from 112 PDB structures and annotated manually. An XML structure was defined to exchange and store the LRRs. LRRML provides a source for homology modeling and structural analysis of LRR proteins. In order to demonstrate the capabilities of the database we modeled the mouse Toll-like receptor 3 (TLR3) by multiple templates homology modeling and compared the result with the crystal structure.

Conclusion

LRRML is an information source for investigators involved in both theoretical and applied research on LRR proteins. It is available at http://zeus.krist.geo.uni-muenchen.de/~lrrml.
Underutilization of information and knowledge in everyday medical practice: Evaluation of a computer-based solution
Authors: Zakim David , Braun Niko , Fritz Peter , Alscher Mark Dominik
Published: November 2008

Background

The medical history is acknowledged as the sine qua non for quality medical care because recognizing problems is pre-requisite for managing them. Medical histories typically are incomplete and inaccurate, however. We show here that computers are a solution to this issue of information gathering about patients. Computers can be programmed to acquire more complete medical histories with greater detail across a range of acute and chronic issues than physician histories.

Methods

Histories were acquired by physicians in the usual way and by a computer program interacting directly with patients. Decision-making of what medical issues were queried by computer were made internally by the software, including determination of the chief complaint. The selection of patients was from admissions to the Robert-Bosch-Hospital, Stuttgart, Germany by convenience sampling. Physician-acquired and computer-acquired histories were compared on a patient-by-patient basis for 45 patients.

Results

The computer histories reported 160 problems not recorded in physician histories or slightly more than 3.5 problems per patient. However, physicians but not the computer reported 13 problems. The data show that computer histories reported problems across a range of organ systems, that the problems detected by computer but not physician histories were both acute and chronic and that the computer histories detected a significant number of issues important for preventing further morbidity.

Conclusion

A combination of physician and computer-acquired histories, in non-emergent situations, with the latter available to the physician at the time he or she sees the patient, is a far superior method for collecting historical data than the physician interview alone.