bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Model Pembelajaran Cooperative Learning Dalam Mewujudkan Pembelajaran Humanistik Pada Pelajaran Aqidah Akhlak Kelas IX Di Madrsah Tsanawiyah Hidayatul Mubtadiin
Authors: Solehah Ass Miana , Yanti Dewi , Hasan Mustaqim
Published: March 2023

The Implementation of Cooperative Learning Model in Realizing Humanistic Learning on Aqidah Akhlak Lesson in Hidayatul Mubtadiin Islamic Junior High School Jati Agung, South Lampung Academic Year 2022/2023 is a study aimed to apply the Cooperative Learning model in Aqidah Akhlak learning and realize humanistic learning. Cooperative Learning is a cooperative learning model that prioritizes the activity and cooperation among students in achieving common goals. In this learning model, students are given the opportunity to discuss and exchange information with their peers, resulting in an interactive learning process. The results of this study show that the implementation of Cooperative Learning model can increase the engagement and participation of students in learning, as well as realize humanistic learning that can shape the character and morals of students.
Meningkatkan Aktivitas Belajar Siswa Kelas V Menggunakan Alat Peraga IPA Sistem Pernapasan Manusia di SD Islam Nurul Huda Jatipulo Jakarta
Authors: Pratiwi Neisya , Syofyan Harlinda
Published: March 2023

This research is motivated by learning activities, enthusiasm, and interest in learning owned by fifth-grade students at SD Islam Nurul Huda Jatipulo has decreased, especially in science subjects due to reduced student interest in learning, and less interesting ways of learning so that students are easily bored learning. The purpose of this class action research is to increase the learning activities of fifth-grade students with the use of science props Human respiratory system. The subjects of this class action research are fifth-grade students of SD Islam Nurul Huda Jatipulo Jakarta 2022/2023. The research subjects totaled 15 students consisting of 7 male students and 8 female students. The type of research used is classroom action research (PTK) which includes several cycles consisting of stages such as planning, action, observation, and reflection.  The data analysis techniques used were descriptive qualitative and descriptive quantitative. The results of this study are that in cycle I the percentage of the number of students who met the good category was only 20%, then increased to 80% in cycle II. The average percentage of student learning activities in each aspect continued to increase in cycle I with an average percentage of 43% which then increased in cycle II with an average percentage of 87%.
Production of recombinant expansin and detection by SDS page analysis in Escherichia coli
Authors: GÜNEŞ Serap , EKTİREN Demet , KARAASLAN Mehmet , VARDİN Hasan
Published: March 2023

The study aims to produce Expansin protein isolated from a young tomato plant by using Escherichia coli which is used in recombinant protein production. Continuous culture is the most common method used to grow cells for recombinant protein production. In the study, the K12 strain of E. coli was used as a culture for the production of Expansin protein. The used LeExp1 gene was isolated from a young tomato plant. Since the related gene is found in very small amounts in plants, it has been reproduced using the PCR method and has been made workable with this method. T17 vector (T7 RNA polymerase system), which is frequently used in the production of recombinant protein, was used as the bacterial expression vector. The T7 RNA polymerase system is a commonly used vector in E. coli. With the transfer, the E. coli bacterium was given the ability to produce recombinant protein. Whether the obtained recombinant protein expressed the appropriate protein was determined by SDS Page analysis.
Role of Milk Micronutrients in Human Health
Authors: Cimmino Fabiano , Catapano Angela , Petrella Lidia , Villano Ines , Tudisco Raffaella , Cavaliere Gina
Published: March 2023

The aim of this review is to provide an overview of different compositions, in terms of main minerals and vitamins, of milk from animal species that represent the most common source of this food for humans, highlighting the uniqueness of nutritional qualities linked to animal species. It is known that milk is an important and valuable food for human nutrition, representing an excellent source of nutrients. Indeed, it contains both macronutrients (proteins, carbohydrates, and fat) that contribute to its nutritive and biological value and micronutrients represented by minerals and vitamins, which play a relevant role in the body’s various vital functions. Although their supply is represented by small quantities, vitamins and minerals are important components for a healthy diet. Milk composition in terms of minerals and vitamins differs between various animal species. Micronutrients are important components for human health as their deficiency is causes of malnutrition. Furthermore, we report on the most significant metabolic and beneficial effects of certain micronutrients in the milk, emphasizing the importance of this food for human health and the need for some milk enrichment procedures with the most relevant micronutrients to human health.
LC-ESI-QTOF-MS2 Characterization of Phenolic Compounds in Different Lentil (Lens culinaris M.) Samples and Their Antioxidant Capacity
Authors: Xia Menglu , Li Minhao , de Souza Thaiza Serrano Pinheiro , Barrow Colin , Dunshea Frank Rowland , Suleria Hafiz Ansar Rasul
Published: March 2023

Background: Lentil (Lens culinaris M.) is a legume widely consumed worldwide. It is rich in bioactive compounds, including polyphenolic compounds that contribute to positive health benefits. Methods: This study aimed to determine the phenolic content and antioxidant activity of black, red, green, and brown whole lentils. Towards this end, the lentils’ phenolic compounds were evaluated regarding their total phenolic content (TPC), total flavonoid content (TFC), total tannin content (TTC), total condensed tannin (TCT), total proanthocyanin content (TPAC), total anthocyanin content (TAC). For the antioxidant activity 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), hydroxyl radical scavenging activity (•OH-RSA), ferrous ion chelating activity (FICA), reducing power assay (RPA) and phosphomolybdate (PMA) assay were accessed. To identify individual phenolic compounds, liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF-MS2) was used. Results: The results showed that green lentils exhibited the highest TPC (0.96 mg gallic acid equivalents (GAE)/g) whereas red lentils presented the highest TFC (0.06 mg quercetin equivalents (QE)/g). Black lentils were noted with the highest TCT (0.03 mg catechin equivalents (CE)/g), TPAC (0.009 mg cyanidin chloride equivalents (CCE)/g), and TAC (3.32 mg/100 g) contents. While the greatest TTC (2.05 mg tannic acid equivalents (TAE)/g) was observed in the brown lentil. Regarding the total antioxidant capacity, red lentils (4.01 mg ascorbic acid equivalents (AAE)/g) presented the greatest activity, whereas the lowest was found in the brown samples (2.31 mg AAE/g). The LC-ESI-QTOF-MS2 tentatively identified a total of 22 phenolic compounds, containing 6 phenolic acids, 13 flavonoids, 2 lignans, and 1 other polyphenol. The relationships among phenolic compounds by Venn Diagram showed a high number of overlapping compounds in brown and red lentils (6.7%), and a low number of overlapping compounds between the green, brown, and black lentils (2.6%). Flavonoids were the most abundant phenolic compound within the studied whole lentils, with the brown lentils being the richest in phenolic compounds, especially flavonoids. Conclusions: This study emphasized a comprehensive understanding of the antioxidant potential of lentils and disclosed the phenolic distribution across various lentil samples. This may increase interest in the development of functional food products, nutraceutical ingredients, and pharmaceutical applications with lentils.
Diagnostic Performance of 60 MHz High-Definition Intravascular Ultrasound versus Fourier Domain Optical Coherence Tomography for Identifying Plaque Rupture, Plaque Erosion, and Thrombosis in a Rabbit Model
Authors: Wang Gang , Qiao Weishen , Xing Chun , Yao Zhibo , Sun Yufei , Huang Xingtao , Wang Xuedong , Liu Qi , Zhang Ruoxi , Luo Xing , Yu Yongmei , Dai Jiannan , Hou Jingbo , Yu Bo
Published: March 2023

Background: Most acute coronary syndromes occur due to coronary thrombosis caused by plaque rupture (PR) and plaque erosion (PE). Precise in vivo differentiation between PR and PE is challenging for intravascular imaging. This study is the first to determine the diagnostic performance of the novel 60 MHz high-definition intravascular ultrasound (HD-IVUS) for differentiating atherosclerotic plaque morphology influenced by local hemodynamic flow in rabbits. This study evaluated the diagnostic performance of 60 MHz HD-IVUS in identifying thrombosis in rabbits. Methods: We established 60 rabbit models of atherosclerosis with left common carotid artery (LCCA) stenosis and 30 FeCl3-induced LCCA thrombosis. Intravascular imaging was assessed with 60 MHz HD-IVUS and fourier-domain optical coherence tomography (FD-OCT). The present study investigated the diagnostic accuracy of 60 MHz HD-IVUS for PR and PE, as well as thrombosis, using OCT-diagnosis as a standard reference. Results: 60 MHz HD-IVUS for identifying atherosclerotic plaque morphology using plaque cavity and minor intimal irregularities showed high sensitivity and specificity; 92.0 and 90.0% for identifying OCT-defined PR, and 80.0 and 70.0% for OCT-defined PE, respectively. In a rabbit thrombus model, 60 MHz HD-IVUS showed high sensitivity (88.0%) and specificity (80.0%) in identifying OCT-defined thrombosis. Conclusions: 60 MHz HD-IVUS can accurately identify PR and thrombosis. Further studies should confirm the clinical value of this novel technique in PE diagnosis.
Improving Cross-Cultural Comparability of Measures on Gender and Age Stereotypes by Means of Piloting Methods
Authors: Menold Natalja , Hadler Patricia , Neuert Cornelia
Published: March 2023

  

The study addresses the effects of piloting methods on the reliability and cross-cultural comparability of the measurement of stereotypes. A gender roles instrument from the European Values Study, an ageism instrument, and children stereotypes from the International Social Survey Program were piloted in German and American English and revised based on findings from cognitive interviews, web probing, and expert reviews involving national experts or additionally cross-cultural experts. The original and each piloted version were randomly assigned to respondents in Germany and the U.S. using an online survey and quota samples. The original gender roles and children stereotypes instruments did not face configural invariance and reliability was insufficiently low. The results show that piloting methods can increase insufficient reliability. Measurement invariance could be improved by piloting methods, but effects varied by the type of revisions implemented. Cross-cultural expert reviews and web probing provided more consistent results than other methods. A combination of methods would be optimal to improve reliability and measurement invariance. 
Differential expression of BCAR3 in colorectal cancer.
Authors: Mamoor Shahan
Published: March 2023

Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined public microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential expression of the gene encoding breast cancer anti-estrogen resistance 3, BCAR3, when comparing colorectal tumors to the tissue of origin, the colon. BCAR3 mRNA was present at significantly lower quantities in tumors of the colon as compared to normal colorectal tissue. BCAR3 expression changes may be important for the initiation or progression of human CRC.
Behavioral Intention and Actual Use of Mobile Learning During the COVID-19 Pandemic in the Higher Education System
Authors: Jameel Alaa S. , Karem Mohammed A. , Alheety Ahmed S.
Published: March 2023

ThisstudyaimstoinvestigatetheimpactonBehavioralIntentionand Actual use of Mobile Learning in the Higher Education (HE). The survey was con- ducted at Cihan University Erbil, and the data was collected by questionnaire. 207 valid questionnaires have been analyzed by Structural equation modelling (SEM). The results indicated that performance expectancy, Effort Expectancy, Facilitating Conditions, Hedonic Motivation, and Habit had a positive and significant impact on Behavioral Intention to use Mobile learning among the students. On the other hand, Social influence and Price Value had an insignificant impact on Behavioral Intention to use Mobile learning among the students. Besides that, the current study reported that behavioral intention directly impacts user behavior (UB). At the same time, facilitating conditions and Habit had an insignificant impact on user behavior.
Penerapan Asuhan Keperawatan Jiwa pada Tn.L Melalui Pendekatan Strategi Pelaksanaan (Sp-1-4) dengan Masalah Halusinasi di Ruangan Sorik Merapi
Authors: Sagala Rizky Yanti
Published: March 2023

Auditory hallucinations are voices that are not real, hear voices talking, mocking, modifying, threatening, ordering to do something dangerous. The purpose of this writing is to provide spiritual care to Mr.L at RSJ. Prof. Dr. Muhammad Ildrem Medan. The descriptive writing method is a case study by conducting nursing care to patients with auditory hallucination sensory perception problems with a treatment implementation strategy (SP) which was carried out for 14 days. Family support is an important factor in efforts to increase motivation so that it can have a positive effect on psychological health. Data collection techniques were carried out using interview techniques, observation and physical examination. The difficulty problem found in Mr.L patients is auditory hallucinations. With 14 days of management, Mr.L can control auditory hallucinations by scolding, taking medication regularly, talking to other people, doing scheduled activities. Suggestions in the management of patients with auditory hallucinations are expected that with this research medical staff can build a trusting relationship with clients so that good communication can emerge and clients can express their problems in order to achieve delivery, the role of the family is expected to accompany schizophrenic patients by accompanying and providing emotional support so that schizophrenic patients feel cared for the patient's recovery.
Data-driven placement of PM2.5 air quality sensors in the United States: An approach to target urban environmental injustice
Authors: Kelp Makoto , Fargiano Timothy , Lin Samuel , Liu Tianjia , Turner Jay , Kutz Nathan , Mickley Loretta
Published: March 2023

In the United States, citizens and policymakers heavily rely upon Environmental Protection Agency (EPA) mandated regulatory networks to monitor air pollution; increasingly they also depend on low-cost sensor networks to supplement spatial gaps in regulatory monitor networks coverage. Although these regulatory and low-cost networks in tandem provide enhanced spatiotemporal coverage in urban areas, sensors are located often in higher income, predominantly White areas. Such disparity in coverage may exacerbate existing inequalities and impact the ability of different communities to respond to the threat of air pollution. Here we present a study using cost-constrained multiresolution dynamic mode decomposition (mrDMDcc) to identify the optimal and equitable placement of fine particulate matter (PM2.5) sensors in four U.S. cities with histories of racial or income segregation: St. Louis, Houston, Boston, and Buffalo. This novel approach incorporates the variation of PM2.5 on timescales ranging from one day to over a decade to capture air pollution variability. We also introduce a cost function into the sensor placement optimization that represents the balance between our objectives of capturing PM2.5 extremes and increasing pollution monitoring in low-income and nonwhite areas. We find that the mrDMDcc algorithm places a greater number of sensors in historically low-income and nonwhite neighborhoods with known environmental pollution problems compared to networks using PM2.5 information alone. Our work provides a roadmap for the creation of equitable sensor networks in U.S. cities and offers a guide for democratizing air pollution data through increasing spatial coverage of low-cost sensors in less privileged communities.
A method for the measurement of seismic attenuation in polar firn
Authors: Agnew Ronan , Clark Roger , Booth Adam , Brisbourne Alex , Smith Andrew
Published: March 2023

We present seismic measurements of the firn column at Korff Ice Rise, West Antarctica, including measurements of compressional- and shear-wave velocity and attenuation. We describe a modified spectral-ratio method of measuring the seismic quality factor (Q) based on analysis of diving waves, which enables us to characterise the attenuative structure of firn in greater detail than has previously been possible. The compressional-wave quality factor, Qp, increases from 20 ± 10 in the uppermost firn to 423 ± 260 between 77 and 86 m depth, and the shear-wave quality factor, Qs, increases from 16 ± 9 in the uppermost firn to 100 ± 87 between 49 and 64 m depth. Our modified spectral-ratio method aids the understanding of the seismic structure of firn and benefits characterisation of deeper glaciological targets, being particularly impactful for correcting reflection amplitudes in wide-angle seismic data.
Multi-scale rupture growth with alternating directions in a complex fault network during the 2023 south-eastern Türkiye and Syria earthquake doublet
Authors: Okuwaki Ryo , Yagi Yuji , Taymaz Tuncay , Hicks Stephen
Published: March 2023

A devastating doublet of earthquakes with moment magnitude Mw 7.9 and Mw 7.6 earthquakes contiguously occurred in SE Türkiye near the NW border of Syria. Here we perform a potency-density tensor inversion to simultaneously estimate rupture evolution and fault geometry for the doublet. We find the initial Mw 7.9 earthquake involved discrete episodes of supershear rupture and back-rupture propagation, and was triggered by initial rupture along a bifurcated splay of the East Anatolian Fault. The second Mw 7.6 event was triggered by the earlier Mw 7.9 event, and it involved more extensive supershear rupture along a favorably curved fault, and was likely stopped by geometric barriers at the fault ends. Our results highlight the multi-scale cascading rupture growth across the complex fault network that affects the diverse rupture geometries of the 2023 Türkiye earthquake doublet, contributing to the strong ground shaking and associated devastation.
Citizen neuroscience: wearable technology and open software to study the human brain in its natural habitat
Authors: Jafarzadeh Esfahani Mahdad , Sikder Niloy , Horst Rob ter , Weber Frederik D. , Daraie Amir Hossein , Appel Kristoffer , Bevelander Kris , Dresler Martin
Published: March 2023

Citizen science allows the public to participate in various stages of scientific research, including study design, data acquisition, and analysis of the resulting data. Citizen science has a long history in several fields of the natural sciences, and with recent developments in technology, neuroscience has also become more accessible to citizen scientists. This development was largely driven by the development of minimal sensing systems for the consumer market, allowing for do-it-yourself (DIY) or quantified-self (QS) investigations of an individual's brain. While most subfields of neuroscience require sophisticated monitoring devices in the laboratory, the study of sleep characteristics has been widely embraced by citizen neuroscientists, likely due to the strong influence of sleep quality on waking life and an increasingly broad accessibility of relevant non-invasive consumer devices. Here, we introduce into the emerging field of citizen neuroscience, illustrating examples of citizen neuroscience projects in the field of sleep research. We then give an overview on wearable technologies for tracking human neurophysiology, and on open software to run them, each with unique capabilities and intended purposes. Finally, we discuss chances and challenges in citizen neuroscience research, and suggest how to improve studying the human brain outside the laboratory.
A developmental investigation of group concepts in the context of social hierarchy: Can the powerful impose group membership?
Authors: Noyes Alexander , Gerdin Emily , Rhodes Marjorie , Dunham Yarrow
Published: March 2023

Group membership is not always voluntary and can be imposed within a social context; moreover, those with power disproportionately shape group membership. We asked if children and adults view group membership as imposed by the powerful. We undertook four studies (465 children ages 4-9, 150 adults): Studies 1-2 used novel minimal groups; Study 3 used ‘cool’ and ‘uncool’; Study 4 used novel ethnic groups. In the first three studies, children saw groups varying in power asserting that a non-categorized individual ought to belong to one of the operating groups in the context. Adults indicated that the declarations of the high-power group (and only the high-power group) made the individual a member of the declared group. Young children rejected that group membership could be imposed. In Study 4, children of all ages reasoned that the high-power group could decide membership for a consenting individual and impose clothing restrictions on a non-consenting individual; unlike adults, children of all ages did not reason the high-power group could impose group membership more frequently than chance. Taken together, adult participants consistently reasoned that group membership was imposed and disproportionately by those with power but children, more often than adults, reasoned that group membership was voluntary.
An Updated Guide to Robust Statistical Methods in Neuroscience
Authors: Wilcox Rand R. , Rousselet Guillaume A
Published: March 2023

There is a vast array of new and improved methods for comparing groups and studying associations that offer the potential for substantially increasing power, providing improved control over the probability of false positives, and yielding a deeper and more nuanced understanding of data. These new techniques effectively deal with four insights into when and why conventional methods can be unsatisfactory. But for the non-statistician, this vast array of techniques for comparing groups and studying associations can seem daunting. This unit briefly reviews when and why conventional methods can have relatively low power and yield misleading results. The main goal is to suggest guidelines regarding the use of modern techniques that improve upon classic approaches such as Pearson’s correlation, ordinary linear regression, ANOVA and ANCOVA. This updated version includes recent advances dealing with effect sizes, including situations where there is a covariate. The R code, figures and accompanying notebooks have been updated as well.
Apathy and Motivation: Biological Basis and Drug Treatment
Authors: Costello Harry , Husain Masud , Roiser Jonathan Paul
Published: March 2023

Apathy is a disabling syndrome associated with poor functional outcomes that is common across a broad range of neurological and psychiatric conditions. Currently there are no established therapies specifically for apathy, and safe and effective treatments are urgently needed. Advances in the understanding of motivation and goal-directed behaviour in humans and animals has shed light on the cognitive and neurobiological mechanisms contributing to apathy, providing an important foundation for the development of new treatments. Here, we review the cognitive components, neural circuitry, and pharmacology of apathy and motivation, highlighting converging evidence of shared transdiagnostic mechanisms. Though no pharmacological treatments have yet been licensed for apathy specifically, we summarise trials of existing and novel compounds to date, identifying several promising candidates for clinical use and avenues of future drug development.
Gambier (Uncaria gambir Roxb.) Plant Productivity Relation Based On Growing Altitude In Lima Puluh Kota Regency
Authors: Rela Sukma , Sribudiani Evi , Darlins Viny Volcherina
Published: March 2023

Gambier cultivation location is usually carried out on sloping land which results in decreased land carrying capacity due to soil erosion. This research was to determine whether the factors of altitude and slope are related to the production of gambier plants and other factors related to gambier production. This research was conducted in Lima Puluh Kota Regency, West Sumatra in September 2020. The data collection methods is to use the interview method, observation and document study. Interview and observation methods were used to obtained gambier production data, gambier harvesting, gambier processing, general conditions of the research location, visual appearance of soil erosion, height of the gambier growing area, topography and soil type. Indirect data were collected using the document study method. The selection of informants was carried out by purposive sampling with a total of 10 people. Data analysis used qualitative descriptive analysis by linking the informants 'answers with document studies, then doing a description in the form of gambier production as outlined in the informants' responses. Altitude has no relation to the production of gambier, but the factors of price, treatment process, soil type and the choice of mixed plant species are factors related to gambier production in Lima Puluh Kota Regency. The slope factor has no relation to the production of gambier in Lima Puluh Kota Regency. Land owners still observe the principles of soil and water conservation by applying mulch (ground cover) from the dregs of gambier and conducting mixed planting with seasonal and annual plant types.
STRATEGI PENGELOLAAN INDUSTRI ROTAN BERKELANJUTAN DI KOTA PEKANBARU
Authors: Yolanda Gita Melisa , Putra Ridwan Manda , . Suwondo
Published: March 2023

This study aims to determine the status of the sustainable management of the rattan industry in Pekanbaru City and to design a sustainable management strategy for the rattan industry. The types of data in this study are primary data and secondary data. Interview and observation data collection methods. The data analysis method in this research is multidimensional scaling (MDS). Sustainability was analyzed using MDS analysis with the help of the Rap-Insus Industry software. The status of the sustainable management of the rattan industry in Pekanbaru City in a multidimensional manner is in a fairly continuous category. The results of the analysis of each dimension are the ecological dimension (32.5%) the economic dimension (75.6%) the social dimension (54.3%) the technology dimension (36.1) and the partnership dimension (66.5%). The strategy for sustainable rattan industry management in Pekanbaru City is carried out by establishing policies in the production process (product quality standardization), processing of waste from industrial activities, and rules and policies in the use of raw materials.
Analisis Daya Saing Produk Bambu Indonesia di Pasar Internasional
Authors: Sitanggang Vera Junita BR , Simbolon Maria S. T. , Simangunsong Bintang C. H.
Published: March 2023

Indonesia is the third richest country in Asia on bamboo resources. In Indonesia, bamboo has been widely used to substitute wood on many applications and also exported in certains bamboo products, such as sticks (used primarily for plaiting), charcoals, flooring, plywood, mats and screens, plaits and plaiting articles, pulp, and paper articles. This research aimed to analyse comparative and competitive advantages of Indonesian bamboo products in international market, including the factors effect its export growth on the period 2013 to 2017. Analysis was conducted under techniques RCA (Revealed Comparative Advantage), TSI (Trade Specialization Index) and CMS (Constant Market Share). Overall, the results showed that bamboo sticks and bamboo charcoals had strong and mature competitive advantages. However, bamboo flooring, bamboo plywood, bamboo mats and screens, and bamboo plaits and plaiting articles had weak competitive advantages and were on growing phase. Bamboo pulp and paper articles had had strong competitive advantages, but it was lessening to the phase of re-importing. The results of CMS analysis showed that commodity composition factor had positively affected export growth, while standard growth and competitiveness factors gave negative effect to Indonesian bamboo export growth.
Effect of Application, Duration and Dosing Frequency on the Efficacy and Adverse Effect of Adapalene in Acne Vulgaris: an Open-Label Randomized Controlled Study
Authors: Jha Prasanna Kumar , Singh Satyendra Kumar , Rai Tulika
Published: March 2023

Introduction: Topical retinoids are the mainstay of treatment for mild and moderate acne but longer duration of application causes adverse effects. The study aimed to evaluate the effect of application, duration, and dosing frequency on the efficacy and adverse effect of Adapalene in Acne Vulgaris.Materials and Methods: The study design was an open-label randomized controlled split-face trial. Patients with acne grades 1 and 2 were randomized into three groups using the split-face technique on the right and left sides. On the right side, patients applied adapalene daily in all the groups and alternately on the left face. The three groups of the study were overnight, 1 hour, and ½ hour application of adapalene. Follow up period was 4,8 and 12 weeks. Lesion count and side effects were evaluated at each follow-up.Results: Out of 292 who completed the study, the decrease in total lesion count was highest in the overnight group. Regarding specific lesion count, the decrease in non-inflammatory lesions was highest in the overnight group. However, short contact therapy with 1-hour application showed comparable efficacy with the overnight group in regards to inflammatory lesion count. There was a significant reduction of lesions in all groups from baseline to 12 weeks, with ½ hour group having minimal side effects followed by 1 hour and overnight.Conclusion: Short contact therapy for acne shows promising results in regard to efficacy and better tolerance.
Out of Pocket Expenditure in Patients on Maintenance Hemodialysis: A Single Center Study
Authors: Agrawaal Krishna Kumar , Shah Santosh
Published: March 2023

Introduction: The government of Nepal has been providing free dialysis for a lifetime to its citizen since 2016. Most of the patients have to spend from pocket to meet their medical demands to sustain life. This leads to a financial burden and may lead to the sale of the property. The aim of this was study to look into different categories of expenses done by patients in the Bipanna nagarik free HD program provided by the government of Nepal.Materials and Methods: This descriptive cross-sectional study was carried out from 9th February 2022 till 30th September 2022 under the Nephrology Unit, Department of Internal Medicine at Universal College of Medical Sciences, Bhairahawa, Nepal. Ethical clearance was taken from the Institutional Review Committee (IRC letter reference no. UCMS/IRC/049/22). Patients receiving free basic hemodialysis services under the Bippana Nagarik Scheme of the Government of Nepal and giving informed and written consent were enrolled in the study. Non-Probability Sampling Method – Convenience Sampling was done.Results: In our study of 50 patients on HD, the mean age was 46.24 ± 15.31 years. The mean duration of dialysis of the study population was 126.80 ± 332.52 months. The average family income per annum was approximately NRs. 31000. The total out-of-pocket expenditure was approximately NRs. 35305/month. The cost of blood investigations was approximately NRs. 13000 in three months.Conclusion: The monthly out of pocket expenditure was approximately NRs. 35000 which was directly related to hemodialysis in spite of free basic hemodialysis services by the Government of Nepal.
Tanggungjawab Pelaku Usaha Rumah Makan Padang Terhadap Perolehan Sertifikasi Halal di Kota Pekanbaru
Authors: Putra Muhammad Yogi Riazmi , Hasnati Hasnati , Triana Yeni Triana
Published: March 2023

This writing is entitled the responsibility of business actors for Padang restaurants to obtain halal certification, it is necessary to pay attention to the safety of food products that are now freely circulating. Not only in terms of health but also guarantee the halal of the product. Although there have been various regulations made by the Government of Indonesia, but still found the existence foods that do not have label certified. The aim of this writing is to find out how the protection of consumer laws and legal consequences received by business actors related to the distribution of food products that are not halal certified. In this paper, the authors use normative research methods. Which examine and analyze the legislation and the linkage of legal principles relating to the labeling of halal food products between Law no. 8 of 1999 about protection of consumer with Law no. 33 of 2014 about Halal Product Guarantee. The results of the analysis obtained are the protection of consumer law against non halal certified food products arranged in Law no. 8 of 1999 about protection of consumer, Law no. 33 of 2014 about Halal Product Guarantee, and Government Regulation Number 69 years 1999 on about Label and Food advertising, while the legal effect that the business actor receives on the distribution of non halal certified food products is by imposing administrative punishment and criminal penalty.
Investigation of the effect of perineural invasion on survival rates in rectal tumors.
Authors: OZGEN Utku , SUNGURTEKİN Uğur , DEMİRKAN Neşe
Published: March 2023

Purpose: Colorectal cancers compose the third most common cancer group leading to death, with increasing rates in developed countries after lung and breast cancers. Rectal cancers make up about 30% of all colorectal cancers. Although many factors affecting recurrence and survival in rectal cancer have been identified, the stage of the tumor is the most important prognostic factor. However, many additional parameters that can be associated with survival and affect the adjuvant treatment plan have been identified besides the stage. Perineural invasion (PNI) is one of the parameters that can be associated with survival and affect the adjuvant treatment plan in colorectal cancers. The aim of this study is to investigate the effects of various histopathological prognostic factors, including PNI, on disease-free survival, overall survival, and recurrence rates in patients with rectal cancer who underwent surgery. Materials and methods: The clinical records of patients diagnosed with rectal cancer and operated on at the Department of General Surgery, Faculty of Medicine, Pamukkale University between 2008-2014 were reviewed. To investigate the factors affecting disease-free survival, recurrence rates, and overall survival, the presence of PNI, serum CEA levels, cTNM stage, pT stage, pN stage, number of metastatic LNs, tumor budding status, histopathological grades, lymphocyte infiltration, and presence of desmoplasia were evaluated in patients.

Results: A total of 124 patients were included in the study. 42 patients (33.9%) had PNI while 82 patients (66.1%) did not have PNI. Of the 45 patients with recurrence, 26 had PNI while 19 did not have PNI. Of the 79 patients without recurrence, 16 had PNI while 63 did not have PNI. Similarly, PNI was seen more frequently in deaths related to the disease. The 3-year average survival of patients with and without PNI was 55% and 89%, respectively (p
Establishing the Most Important Clinical Skills for New Graduate Veterinarians by Comparing Published Lists with Regional Stakeholder Expectations: A Bangladesh Experience
Authors: Paul Thomby , Hoque Md. Ahasanul , Dey Tuli , Sutradhar Bibek Chandra , Mannan Abdul , Sarker Debashish , Mohsin Md. Abu Shoieb , Baillie Sarah
Published: March 2023

Veterinary clinical skills training is evolving rapidly around the world and there is increasing interest in Bangladesh in opening clinical skills laboratories and using models in teaching. The first clinical skills laboratory was opened at Chattogram Veterinary and Animal Sciences University in 2019. The current study aimed to identify the most important clinical skills for veterinarians in Bangladesh to inform the further development of clinical skills laboratories and ensure resources are deployed effectively and efficiently. Lists of clinical skills were collated from the literature, national and international accreditation standards, and regional syllabi. The list was refined through local consultation, focused on farm and pet animals, and was disseminated via an online survey to veterinarians and final-year students who were asked to rate the level of importance of each skill for a new graduate. The survey was completed by 215 veterinarians and 115 students. A ranked list was generated with injection techniques, animal handling, clinical examination, and basic surgical skills among the most important. Some techniques requiring specific equipment and some advanced surgical procedures were considered less important. As a result of the study, the most important clinical skills for a new graduate in Bangladesh have been identified for the first time. The results will inform the development of models, the use of clinical skills laboratories, and the design of clinical skills courses for veterinary training. Our approach of drawing upon existing lists followed by local stakeholders consultation is recommended to others to ensure clinical skills teaching is regionally relevant.
The Effects of Online Learning Transition during the COVID-19 Pandemic in Pakistan
Authors: Shahid Shiza , Shahid Amina
Published: March 2023

Amidst the global pandemic of Covid-19, online learning has been widely used around the country. Teachers’ and students' experiences related to online learning have been explored in this study through the online survey method. This was a novel experience for teachers and students as both groups were not familiar with this mode of education.  Hence, it was imperative to explore their experiences with online learning amidst a pandemic. The data for this study was collected from public and private universities of Faisalabad and Lahore. A total of 430 participants (N=100 teachers & N= 330 students) from Faisalabad and Lahore's colleges and universities were included in the study. The data was gathered using an online survey. The following areas were found to be crucial to the satisfaction of both teachers and students in online classes. Student-faculty contact, technical assistance, organized online classes, and adaptations to enable practical classes were all incorporated in these areas. Since then, this research has focused on a dynamic phenomenon that includes several facets of online learning.
Tingkat Penetasan Penyu Hijau di Pulau Pandan Kawasan Konservasi Pulau Pieh, Sumatera Barat
Authors: Hanif Andriyatno , Damanhuri Harfiandri , Suparno Suparno , Rusli Mohd Uzair
Published: March 2023

Kajian penelitian tingkat penetasan penyu dilakukan di Pulau Pandan, Kawasan Konservasi Pulau Pieh. Tujuan kajian untuk melihat faktor mempengaruhi keberhasilan penetasan sarang semi alami, dan melihat capaian optimal tingkat penetasan. Penelitian dilaksanakan bulan Januari – Juni 2022 dengan mengkoleksi data jumlah telur, morfometrik, kedalaman sarang, dan lama waktu inkubasi, serta data sekunder. Metode penelitian secara kuantitatif dengan analisis regresi linear berganda untuk melihat pengaruh variabel bebas dengan variabel terikat. Hasil analisis korelasi antara jumlah telur dengan panjang karapas didapati hubungan positif dengan kategori rendah (r=0,215, t=2,253, df=26, p=0,033), sedangkan jumlah telur dengan kedalaman sarang memiliki hubungan negatif dengan kategori sangat rendah (r=0,154, t=1,684, df=26, p=0,104), sementara pengaruh panjang karapas, kedalaman sarang secara bersamaan terhadap jumlah telur didapati nilai R2 = 29,2%. penyu hijau memiliki telur tebanyak; 131 butir, dan jumlah telur sedikit; 29 butir, dengan rata-rata jumlah telur; 93,86 butir. Korelasi tingkat penetasan dengan kedalaman sarang didapati hubungan positif (r=0,019, t=2,324, df=367, p=0,021), tingkat penetasan dengan masa inkubasi hubungan posistif dengan kategori sangat rendah (r = 0,021, t=2,520, df=367, p=0,012), dan pengaruh bersamaan didapati nilai R2 = 3,6%. Tingkat penetasan telur penyu berada pada kondisi optimum ditemukan angka rata-rata; 86,67%, penyu mendarat dan bertelur dominan ukuran dewasa dengan nilai rata-rata panjang karapas; 97,10 cm, serta lama inkubasi pada rentang; 45-58 hari.
Pola Pertumbuhan dan Faktor Kondisi Ikan Selangat (Anodontostoma chacunda, Hamilton 1822) di Perairan Pantai Senggarang, Tanjungpinang
Authors: Zahid Ahmad , Sari T. Ersti Yulika , Lahay Almira Fardani
Published: March 2023

Pola pertumbuhan ikan yang ditentukan melalui hubungan panjang-bobotnya merupakan suatu pendekatan yang banyak diterapkan dalam pengelolaan perikanan dan dapat digunakan dalam menentukan kondisi ikan. Hubungan panjang-bobot dan faktor kondisi ikan selangat dianalisis dari ikan contoh yang dikumpulkan dari nelayan pada Juni hingga Agustus 2022 di Pantai Senggarang, Tanjungpinang. Penelitian bertujuan untuk menentukan pola pertumbuhan dan faktor kondisi ikan selangat. Sebanyak 422 ekor ikan contoh diukur panjang baku (mm) dan ditimbang bobotnya (g). Hasil penelitian menunujukkan bahwa nilai b sebesar 3,04 yang mengindikasikan pola pertumbuhannya isometrik. Nilai faktor kondisi berkisar pada 0,84 hingga 1,04. Pola pertumbuhan dan faktor kondisi tidak konstan, bervariasi musiman, berkait dengan banyak faktor seperti siklus reproduksi, ketersediaan makanan, dan faktor lingkungan dan habitatnya.
Indeks Kesehatan Terumbu Karang di Perairan Siantan Selatan, Kabupaten Kepulauan Anambas
Authors: Ritonga Abdul Rahman , Ruswanti Corina Dewi , Jaka Fadli , Putri Novita Permata , Muharam Muhammad Rifat , Kurniawan Dedy
Published: March 2023

Kondisi ekosistem terumbu karang di perairan Siantan Selatan telah mengalami penurunan akibat penangkapan ikan yang tidak ramah lingkungan seperti penggunaan bom dan potassium. Kerusakan terumbu karang mengakibatkan penurunan produtivitas dan keanekaragaman ekosistem terumbu karang. Analisis indeks kesehatan terumbu karang bertujuan untuk menggambarkan dan membandingkan kondisi terumbu karang di beberapa lokasi. Sehingga penelitian ini bertujuan untuk menilai indeks kondisi kesehatan terumbu di 22 stasiun penelitian yang terletak di tiga lokasi yaitu, Pulau Kiabu, Pulau Bawah dan Pulau Telaga. Analisis indeks kesehatan terumbu karang dilakukan berdasarkan presentase tutupan karang, biomassa ikan karang dan tingkat resiliensi. Hasil penelitian menunjukkan Pulau Telaga memiliki nilai indeks kesehatan terumbu karang tertinggi dengan nilai berkisar 5 -10, sedangkan Pulau Kiabu dan Pulau Bawah dengan nilai 2 - 7 dan 3 - 8. Analisis korelasi biomassa ikan karang dengan presentase tutupun karang menujukkan korelasi positif dimana tutupan karang yang tinggi memiliki biomassa ikan yang tinggi.
Karakteristik Ekologi Ekosistem Mangrove di Perairan Estuari Sei Carang Kota Tanjungpinang, Kepulauan Riau
Authors: Zakia Rahima , Lestari Febrianti
Published: March 2023

Kawasan Perairan Estuari Sei Carang memiliki ekosistem mangrove yang merupakan habitat penting bagi biota yang ada didalamnya serta memiliki peranan sebagai pelindung kawasan pesisir dari hempasan angin, arus dan ombak dari laut, serta berperan juga sebagai benteng dari pengaruh banjir dari daratan. Penelitian ini bertujuan untuk mengetahui karakteristik ekologi ekosistem mangrove di Perairan Estuari Sei Carang Kota Tanjungpinang. Penelitian ini dilaksanakan pada bulan Oktober hingga Desember 2021 yang berlokasi di Perairan Estuari Sei Carang. Lokasi pengamatan ditentukan menggunakan metode survey dengan pemilihan titik sampling menggunakan purposive sampling. Karakteristik ekologi ekosistem mangrove yang diamati yaitu sebaran jenis, kerapatan, persentase tutupan serta parameter perairan meliputi suhu, pH, salinitas, DO, substrat, dan tipe pasang surut. Beberapa jenis mangrove yang dijumpai pada Perairan Estuari Sei Carang diantaranya Rhizophora apiculata, Rhizophora mucronata, Rhizophora lamarckii, Bruguiera gymnorrihiza, Bruguiera sexangula, Sonneratia alba, Xylocarpus granatum, Ceriops tagal, Lumnitzera littorea dan  Avicennia marina Rata-rata kerapatan  serta persentase tutupan  mangrove di Perairan Sei Carang berada pada kategori padat yang menunjukkan bahwa kerapatan  serta persentase tutupan masuk ke dalam kriteria sedang dan hal ini menunjukkan kondisi mangrove masih dalam keadaan baik. Berdasarkan hasil analisis data kerapatan dan persentase tutupan mangrove stasiun 1 memiliki nilai yang paling tinggi dengan nilai kerapatan 4467 ind/Ha dan persentase tutupan sebesar 82,8%.
Response of nutrient elements in leaf tissues of sweet sorghum (Sorghum bicolor) to interactive effects of soil-drenched triterpenoid phytonematicides
Authors: MALEKA K. G. , MASHELA P. W. , POFU K. M.
Published: March 2023

Root-knot (Meloidogyne species) nematode population densities on various crops, including sweet sorghum, were consistently decreased by three triterpenoid phytonematicides that are currently available as Nemarioc-AL, Nemafric-BL and Mordica. These compounds have chemically different active ingredients. The interaction between triterpenoid phytonematicides and the accumulation of nutrients in plant leaf tissues has not yet been studied, with the exception of Nemarioc-AL and Nemafric-BL. The objective of this study was to investigate the interactive effects of triterpenoid phytonematicides on accumulation of nutrient elements in leaf tissues of sweet sorghum under microplot conditions in Limpopo Province, South Africa during 2020 and 2021. Nemarioc-AL, Nemafric-BL and Mordica were laid in a 2 × 2 × 2 factorial experiment, respectively. The test treatments were arranged in a randomized complete block design, with eight replications, conducted on artificial microplots containing steam pasteurized soil. At 150 days after inoculation, the second order interaction (Nemarioc-AL × Nemafric-BL × Mordica) significantly (P=0.05) increased accumulation of Ca, K and Mg in leaf tissues of sweet sorghum, but without affecting P, Fe, Na and Zn. Relative to untreated control, second order interaction increased Ca, K and Mg by 206, 164 and 289%, respectively. In accordance with the density-dependent growth principles of entities exposed to allelochemicals, soil-drenched administration of triterpenoid phytonematicides dramatically modified the accumulation of nutritional components in leaf tissues of sweet sorghum.