bluuebunny/crossref_metadata_2025 huggingface dataset:
“Coisas Engraçadas”: análise de interações no contexto de construção de uma narrativa em uma escola de Educação Infantil
Authors: Pancotto André Luiz , Ferreira Marisa Vasconcelos
Published: November 2017

Este trabalho visa contribuir com as reflexões sobre as práticas pedagógicas que envolvem as linguagens oral e escrita nos contextos de Educação Infantil. Para tanto, analisa interações das crianças na construção de uma narrativa escrita coletiva, tendo como recurso a leitura de um livro de imagens. Na análise, enfatizou-se o olhar para as interações e como estasforam constituindo as soluções do grupo para a narrativa. Foram definidos como eixos de análise aspectos relativos ao pensamento, à fala e ao letramento emergente, além dos gestos que contribuíram com a constituição da situação interativa. Por fim, reflete-se sobre a importância de constituir práticas pedagógicas envolvendo as diferentes linguagens na Educação Infantil, articuladamente e inseridas nas práticas sociais.
Editorial
Authors: Scarpa Regina , Prado Ricardo , Gomes Lisandra Ogg
Published: November 2017

“Ah, o boné...!” Para Paulo Carrano, estudioso do tema juventude, essa indumentária inseparável de quase todos os jovens se tornou símbolo da diferença maltratada pela escola, que em sua ânsia uniformizadora, de saudável feitio republicano, não consegue aceitar as singularidades expostas em um boné. Na entrevista desta edição de Veras o professor da Faculdade de Educação da Universidade Federal Fluminense (UFF), e coordenador do grupo de estudos Observatório Jovem do Rio de Janeiro, fala sobre bonés e o que eles sinalizam: o desejo de uma escola que possa ser, simultaneamente, para todos e para cada um. Uma escola atenta à escuta biográfica de seus alunos, o que inclui, necessariamente, saber como é a vida deles fora da escola.
Entrevista: Paulo Carrano - O jovem, seu boné e a escola
Authors: Prado Ricardo , Gomes Lisandra Ogg
Published: November 2017

“Democrática, republicana e o mais singularista possível”: assim deveria ser a escola de Ensino Médio ou da Educação de Jovens e Adultos na análise de Paulo Carrano, professor da Faculdade de Educação e do Programa de Pós-Graduação em Educação da Universidade Federal Fluminense (UFF). Uma escola que se interessasse em conhecer a trajetória extraescolar de seus alunos e soubesse escutá-los de forma atenta. A todos, republicanamente, e a cada um, enxergando-o como sujeito cultural completo – inclusive com seu boné...
Cronotopias do lar: reflexões sobre crianças que se mudam
Authors: Queiroz Caroline Trapp de
Published: November 2017

Este artigo coloca em discussão as significações do espaço da casa a partir do movimento realizado por duas crianças que, simultaneamente, viveram o processo de mudança de residência. Para ler o encontro entre Elis e Antônia na casa da qual a primeira está saindo e para a qual a segunda está chegando, e que, por isso mesmo, guarda em um só tom a potencialidade e a memória, a promessa e a gratidão, o futuro e o passado, convocam-se o conceito bakhtiniano de cronotopo e a figura poética do deus romano Jano, ambos relacionados à unidade constituída no entrelaçamento das dimensões do tempo e do espaço. Assim, o cronotopo do quarto figura como enfoque da “visibilidade do tempo”, que no encontro das duas meninas significam um mesmo espaço a partir de referenciais temporais distintos.
Quando a criança perde o lugar: as infâncias e seus (des)lugares
Authors: Milanez Fernanda
Published: November 2017

Este artigo é um recorte da pesquisa de doutorado, situada no campo dos estudos da infância, cujas questões foram sendo esboçadas a partir de alguns cronotopos pinçados em experiências que envolveram remoções e deslocamentos provocados por desastres ambientais, que se firmaram como questões de investigação para o presente estudo. No que diz respeito às experiências de diferentes infâncias ou às memórias delas, busco compreender como as crianças restabelecem suas relações espaçotemporais nas situações de destruição ou reconstrução de seus territórios. Para tal, convidei interlocutores afetados pelo evento climático da região serrana1 em 2011, dispostos a revisitar locais onde moravam ou estudavam quando a chuva veio. Essa questão se coloca como o objetivo principal deste recorte da pesquisa, embora ainda não conclusiva, que conta com o aporte teórico de Mikhail Bakhtin a partir do seu conceito de cronotopo e de Walter Benjamin, em diálogo com seus conceitos e experiência, memória e infância.
Educação infantil e gêneros nas narrativas da BNCC
Authors: Menezes Flávia Maria de , Monsores Luciana Helena , Dornelles Priscila de Oliveira
Published: November 2017

O propósito deste artigo é contribuir nos debates que se colocam para a questão dos gêneros no contexto da Educação Infantil. Entendemos que essa questão parece ocupar o lugar do silenciamento nos discursos escolares, especialmente quando enunciado “para” as crianças pequenas e suas famílias. O que propomos é um convite ao debate sobre como os corpos das crianças pequenas estão traduzidos nas narrativas das políticas públicas de educação brasileiras, principalmente na Base Nacional Comum Curricular (BNCC) do Ministério da Educação de 2017. Assim, pretendemos neste artigo tensionar as ideias que expressam o lugar dos corpos das crianças pequenas nos textos da BNCC, refletindo sobre as muitas, e necessárias, indagações que os gêneros produzem nos contextos de educação das crianças pequenas.
Biomassas brasileiras aplicadas à remoção de urânio de drenagem ácida de minas por processos de biossorção
Authors: Boniolo Milena Rodrigues , Yabuki Lauren Nozomi Marques , Mortari Daniela Andresa , Menegário Amauri Antonio , Garcia Marcelo Loureiro
Published: November 2017

Este trabalho teve como objetivo avaliar a redução da concentração de urânio em área de drenagem ácida de mina. O Brasil possui a sexta maior reserva de urânio do mundo e há grande quantidade de rejeitos acumulados contendo íons metálicos, semimetálicos e radiotóxicos. O método utilizado neste estudo para remover urânio foi a biossorção mediante a aplicação de biomassas brasileiras. Os efluentes aplicados foram coletados na mina Osamu Utsumi, que pertence às Indústrias Nucleares do Brasil e os biossorventes empregados nos ensaios foram cascas de banana, semente de moringa e borra de café. A decomposição térmica, a porosimetria de adsorção de nitrogênio e a microscopia eletrônica de varredura (MEV) foram realizadas para caracterizar fisicamente os biossorventes. A partir dos resultados obtidos, observou-se que os biossorventes com maior área de superfície e maior volume de poros resultaram em maiores valores de eficiência de remoção, com uma ordem crescente desses parâmetros: cascas de banana < borra de café < sementes de moringa. Considerando as amostras de efluentes com concentração de urânio de 6 mg L-1, as sementes de moringa apresentaram remoção de aproximadamente 87%, enquanto a borra de café e cascas de banana apresentaram remoção de 74 e 56%, respectivamente.
Anticancer prospection of salicin, a historical origin of aspirin
Authors: Islam Muhammad , Dantas Rafael Caetano MagalhÃ£es
Published: November 2017

Salicin (an alcoholic Î²-glucoside), the historical origin of aspirin. It is chemically related to aspirin and tastes bitter like quinine and evident for a number of important biological activities. The human bitter taste receptor TAS2R16 (hTAS2R16) responds to Î²-glucosides such as salicin. Thus, a modulator effect on this receptor may link to salicin-induced anticancer effect. Moreover, it may act by reducing oxidative stress and inflammatory reactions. Among a number of anticancer cellular and molecular mechanisms, salicin is evident to act through suppressing the angiogenic activity in cancer cells. Salicin may be one of the important anticancer drugs. However, the research on this willow plant derived compound is not sufficient, especially in the context of anticancer drug investigation.
Usability meets security: a database case study
Authors: Wang Yong , Rawal Bharat
Published: November 2017

Abstract In this paper, we review security and usability scenarios. We propose security enhancements without losing usability and apply a new approach to popular application systems. Specifically, we analyze database security for access control, auditing, authentication, encryption, integrity control, backups, separation of environment, and secure configuration. Finally, we present our recommendations for system security and usability that work together.
Determination of age- and sex-specific 99th percentiles for high-sensitive troponin T from patients: an analytical imprecision- and partitioning-based approach
Authors: Monneret Denis , Gellerstedt Martin , Bonnefont-Rousselot Dominique
Published: November 2017

Background:

Detection of acute myocardial infarction (AMI) is mainly based on a rise of cardiac troponin with at least one value above the 99th percentile upper reference limit (99th URL). However, circulating high-sensitive cardiac troponin T (hs-cTnT) concentrations depend on age, sex and renal function. Using an analytical imprecision-based approach, we aimed to determine age- and sex-specific hs-cTnT 99th URLs for patients without chronic kidney disease (CKD).

Methods:

A 3.8-year retrospective analysis of a hospital laboratory database allowed the selection of adult patients with concomitant plasma hs-cTnT (<300 ng/L) and creatinine concentrations, both assayed twice within 72 h with at least 3 h between measurements. Absence of AMI was assumed when the variation between serial hs-cTnT values was below the adjusted-analytical change limit calculated according to the inverse polynomial regression of analytical imprecision. Specific URLs were determined using Clinical and Laboratory Standards Institute (CLSI) methods, and partitioning was tested using the proportion method, after adjustment for unequal prevalences.

Results:

After outlier removal (men: 8.7%; women: 6.6%), 1414 men and 1082 women with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 were assumed as non-AMI. Partitioning into age groups of 18–50, 51–70 and 71–98 years, the hs-cTnT 99th URLs adjusted on French prevalence were 18, 33, 66 and 16, 30, 84 ng/L for men and women, respectively. Age-partitioning was clearly required. However, sex-partitioning was not justified for subjects aged 18–50 and 51–70 years for whom a common hs-cTnT 99th URLs of about 17 and 31 ng/L could be used.

Conclusions:

Based on a laboratory approach, this study supports the need for age-specific hs-cTnT 99th URLs.
Proficiency testing program for hemoglobin E, A2 and F analysis in Thailand using lyophilized hemoglobin control materials
Authors: Pornprasert Sakorn , Tookjai Monthathip , Punyamung Manoo , Pongpunyayuen Panida , Treesuwan Kallayanee
Published: November 2017

Background:

There is no external quality assessment (EQA) program for hemoglobin analysis that uses lyophilized hemoglobin control materials with HbA2/E in levels as high as those found in people with the β-thalassemia trait, HbE trait, β-thalassemia/HbE disease or homozygous HbE; these are all found frequently in the southeast Asian population. The aim of this study was to evaluate the efficiency of the control materials used in the established proficiency testing (PT) program at the Associated Medical Sciences-Clinical Service Center (AMC-CSC), Chiang Mai University, Chiang Mai, Thailand.

Methods:

The PT program for Hb analysis and the thalassemia interpretation was established in compliance with ISO/IEC17043:2010. Three cycles per year were performed in 2015 and 2016. In each cycle, three different types of control material were provided to the participants. Each participant analyzed the control materials in the same manner as in their routine practices. Hb analysis results and their thalassemia interpretation codes were entered into the report form and sent back to AMC-CSC.

Results:

The number of participants increased from 63 in 2015 to 76 in 2016. In addition, the number of participants who took part in all three cycles increased from 95.2% (60/63) in 2015 to 100% (76/76) in 2016. All participants reported the correct Hb measurement and type; however, misinterpretations in thalassemia diagnosis were noted.

Conclusions:

The lyophilized hemoglobin control materials prepared at AMC-CSC were used successfully in our PT program. However, the study results indicate the need for further improvement in thalassemia interpretation skills for laboratory staff.
EASI – European Autoimmunity Standardisation Initiative: facing the challenges of diagnostics in autoimmunity
Authors: Damoiseaux Jan , Olschowka Nina , Shoenfeld Yehuda
Published: November 2017

The European Autoimmunity Standardisation Initiative (EASI) has been founded in order to improve autoimmune diagnostics by stimulating the interaction between the clinicians and laboratory specialists, by standardization of autoantibody tests, and by harmonization of testing algorithms. The ultimate goal of EASI is to utilize autoimmune diagnostics in the best way in order to optimize patient care. This mini-review gives an overview of the historical perspective of EASI and summarizes the major achievements.
Diagnostic and prognostic value of presepsin vs. established biomarkers in critically ill patients with sepsis or systemic inflammatory response syndrome
Authors: Brodska Helena , Valenta Jiri , Pelinkova Kveta , Stach Zdenek , Sachl Robert , Balik Martin , Zima Tomas , Drabek Tomas
Published: November 2017

Background:

Inflammatory biomarkers may aid to distinguish between systemic inflammatory response syndrome (SIRS) vs. sepsis. We tested the hypotheses that (1) presepsin, a novel biomarker, can distinguish between SIRS and sepsis, and (2) higher presepsin levels will be associated with increased severity of illness and (3) with 28-day mortality, outperforming traditional biomarkers.

Methods:

Procalcitonin (PCT), C-reactive protein (CRP), presepsin, and lactate were analyzed in 60 consecutive patients (sepsis and SIRS, n=30 per group) on day 1 (D1) to D3 (onset sepsis, or after cardiac surgery). The systemic organ failure assessment (SOFA) score was determined daily.

Results:

There was no difference in mortality in sepsis vs. SIRS (12/30 vs. 8/30). Patients with sepsis had higher SOFA score vs. patients with SIRS (11±4 vs. 8±5; p=0.023), higher presepsin (AUC=0.674; p<0.021), PCT (AUC=0.791; p<0.001), CRP (AUC=0.903; p<0.0001), but not lactate (AUC=0.506; p=0.941). Unlike other biomarkers, presepsin did not correlate with SOFA on D1. All biomarkers were associated with mortality on D1: presepsin (AUC=0.734; p=0.0006; best cutoff=1843 pg/mL), PCT (AUC=0.844; p<0.0001), CRP (AUC=0.701; p=0.0048), and lactate (AUC=0.778; p<0.0001). Multiple regression analyses showed independent associations of CRP with diagnosis of sepsis, and CRP and lactate with mortality. Increased neutrophils (p=0.002) and decreased lymphocytes (p=0.007) and monocytes (p=0.046) were also associated with mortality.

Conclusions:

Presepsin did not outperform traditional sepsis biomarkers in diagnosing sepsis from SIRS and in prognostication of mortality in critically ill patients. Presepsin may have a limited adjunct value for both diagnosis and an early risk stratification, performing independently of clinical illness severity.
Analysis of Control Degrees of Freedom in Batch and Cyclic Processes
Authors: Safari Ayoub , Eslamloueyan Reza
Published: November 2017

Recently, we have proposed a new formulation approach for control degree of freedom (CDOF) analysis of process systems. This formula interrelates the CDOF and elements of a process flow diagram (PFD). The formulation is accurate, easily applicable by process engineers, and needs little prior knowledge of the process under study. This paper describes further about this new formulation and its advantages by applying it to batch and cyclic processes. The results demonstrate the correctness of the method in  determining CDOF for all case studies at both steady state and dynamic conditions. The CDOF for “reheat regenerative Rankine” and “vapor absorption refrigeration” cycles have been determined to be 9 and 8, respectively. The steady state CDOF values for the Rankine and refrigeration cycles have been calculated as 8 and 4, respectivley. Also the CDOF for the process of  “heat pump integrated with batch distillation column”  is 4 that verifies the suggested formula of CDOF. The method also gives beneficial insights about the manipulated variables (MVs) in a control system.
In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves
Authors: Pérez Carlos L. , Donato Maria T. , Hernández Ivones , Paz Lopes Miriam T. , Marrero Evangelina , Herrera Jose A. , Gómez-Lechón Maria J. , Rodeiro Idania
Published: November 2017

Background:

The aqueous extract of the

Methods:

Considering the herb–drug interaction, the aim of this study was to evaluate the potential effects of the

Results:

The extract did not decrease the cell viability after being assayed by the MTT test at up to 1500 μg/mL for 72 h. The exposure of the cultured rat hepatocytes to the product (up to 250 μg/mL) for 48 h increased the activities of CYP-1A2, 2C9, and 2E1 by 1.46-, 1.60-, and 1.51-fold, respectively, compared with the controls. The activities of CYP-2B6, 2D6, and 3A4 were not significantly altered, whereas the activity of P-gp decreased by 2- and 4-fold. In addition, the extracts at 100 and 200 μg/mL significantly increased doxorubicin cytotoxicity in these cells 24 h after treatment.

Conclusions:

The findings indicate that the
Static and non-linguistic quantitative indicators to evaluate Japanese comic dialogues of Manzai
Authors: Maeshiro Tetsuya
Published: November 2017

This paper proposes the use of quantitative indicators to evaluate the comedic success of Japanese “Manzai” performances without using semantic processing or time sequence information. The validity of the proposed indicators was verified by predicting the rankings of the final rounds and decision matches of ten M1 Grand Prix, a national-level humor contest in Japan, using leave-one-out cross validation. The results demonstrate that the proposed indicators are able to predict the ranking of Manzai championships as the mean prediction precision was 0.58 (rank correlation) for final rounds, and 0.70 (champion prediction accuracy) for the decision matches.
Ammonia Leaching of Zinc from Low-grade Oxide Zinc Ores Using the Enhancement of the Microwave Irradiation
Authors: Li Shiwei , Li Haoyu , Chen Weiheng , Peng Jinhui , Ma Aiyuan , Yin Shaohua , Zhang Libo , Yang Kun
Published: November 2017

Irradiated roast treatment and the ammonia leaching processing were conducted to deal with the low-grade oxide zinc ores. The ZnCO3 phase was hard to be attended, which was the reason for the low leaching rate of the complicated zinc ores. The mineral phase transformation of the ZnCO3 phase was generated after the ores irradiated in the microwave at the temperature of 673 K. The irradiated ores generated more small particles, it was the reason that the leaching rate of the complicated zinc ores was increased. When the leaching processing of the irradiated roasted ores was conducted under the conditions of the total ammonia concentration of 6 mol/L, the liquid to solid phase ratio of 11:1, the leaching temperature of 298 K, the leaching time of 150 min and the stirring speed of 400 rpm, 88.3 % of zinc could be achieved, which was the maximum leaching rate of the irradiated ores.
Voltage Sag due to Pollution Induced Flashover Across Ceramic Insulator Strings
Authors: Reddy B Subba , Goswami Arup Kumar
Published: November 2017

Voltage sag or voltage dips are significant to industrial reliability. There is a necessity to characterize the feeder level power quality (PQ) and the PQ performance among various utility companies. Contamination/pollution induced flashover is the ultimate consequence of the creeping discharges across the insulator strings which induce voltage sag. These have a severe threat on the safe and reliable operation of power systems. In the present work an attempt has been made to experimentally investigate the occurrence of voltage sag/dips during pollution induced flashovers. Results show significant dip/sag in the voltage magnitude during the flashover process.
Blockchains and the crypto city
Authors: Potts Jason , Rennie Ellie , Goldenfein Jake
Published: November 2017

Drawing on economic transaction
cost theory, this paper explores how blockchain and
distributed ledger technology could shift the smart city agenda by altering
transaction costs with implications for the coordination of infrastructures
and resources. Like the smart city the crypto city
utilizes data informatics, but can be coordinated
through distributed rather than centralized systems. The
data infrastructure of the crypto city can enable civil society to run local
public goods and services, and facilitate economic and
social entrepreneurship.
A self-portrayal of GI Junior Fellow Matthias Weidlich: Event-driven analysis of service processes
Authors: Weidlich Matthias
Published: November 2017

In domains such as e-commerce, logistics, or healthcare, the conduct of
service processes is widely supported by information systems and event
data is generated continuously during process execution. Such event data
constitutes a valuable source of information to monitor and improve the
respective service processes.

My research focuses on models and methods to support event-driven analysis of
service processes. Specifically, I study how event
logs produced by information systems are used to automatically construct models
for qualitative and quantitative analysis. Aiming at online assessment and
predictive analysis of a process' behaviour, I develop monitoring techniques
that utilise streams of event data produced by diverse sources. Architectures
that enable efficient handling of event streams are another
focal point of my research. In this article, I outline some of the
related research questions and highlight my recent results in these areas.
Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark
Authors: Akuodor Godwin C. , Nwobodo Ndubuisi N. , Megwas Anthony U. , Akpan Joseph L. , Nwachukwu Daniel C. , Asika Ebere C. , Chilaka Kingsley C.
Published: November 2017

Background:

The Icacina senegalensis root bark is traditionally used for the treatment of gastrointestinal disorders in Nigeria. To date, no scientific study has substantiated or refuted this claim.

Methods:

The antidiarrheal and antimicrobial activities of the ethanol root bark extract were investigated in rats and against some selected diarrhea-causing microorganisms.

Results:

The extract significantly decreased the frequency of castor oil-induced diarrhea, and inhibited the masses and volumes of intestinal fluid accumulation in the castor oil-induced enteropooling method. The distance travelled by the charcoal meal was also decreased by the extract gastrointestinal transit method. The extract also strongly inhibited the growth of some selected microorganisms.

Conclusions:

The ethanol extract of the I. senegalensis root bark showed antidiarrheal activity, thus justifying its long folkloric use in diarrhea treatment. The extract also demonstrated antimicrobial activity against selected diarrheal causing organisms.
Efficacy and safety of percutaneous administration of dihydrotestosterone in children of different genetic backgrounds with micropenis
Authors: Xu Dan , Lu Liangsheng , Xi Li , Cheng Ruoqian , Pei Zhou , Bi Yunli , Ruan Shuangsui , Luo Feihong
Published: November 2017

Background:

Exogenous androgen supplement is an optional treatment for micropenis; however, its use in childhood is controversial due to potential side effects.

Methods:

Twenty-three children (mean age: 4.07±3.4 years) with micropenis of unknown causes harboring the 46,XY karyotype were recruited in an open prospective study. Androgen receptor (

Results:

Two patients were found with

Conclusions:

Short term and local application of DHT at low doses in patients with micropenis could accelerate penile growth effectively without evident side effects; however, precautions still need be taken due to the paucity of long term study and the lack of ideal DHT dosage.
Mutation analysis of the phenylalanine hydroxylase gene and prenatal diagnosis of phenylketonuria in Shaanxi, China
Authors: Wang Lin , Wang Xiaobin , He Bin , Cai Na , Li Wei , Lou Chao , Xin Shuwen , Wu Qiuhua , Yu Wenwen , Qiang Rong
Published: November 2017

Background:

This study aims to investigate the spectrum and frequency of phenylalanine hydroxylase (

Methods:

Polymerase chain reaction (PCR) and DNA sequencing analyses were performed to examine the

Results:

Pedigree analysis suggested that the [c.158G>A([p.R53H)][IVS7+2T>A] mutation was located at the same chromatid. However, there was a controversial viewpoint that thought the c.158G>A(p.R53H) variant was a polymorphism in the Chinese. We also found one novel indel mutation and identified the c.59_60delAGinsCC mutation of the

Conclusions:

gene analysis is a crucial method for PKU diagnosis and prenatal genetic prognosis, even though many uncommon mutations would affect the analysis and diagnosis of genetic abnormalities.
The role of enterovirus infections in type 1 diabetes in Tunisia
Authors: Boussaid Imen , Boumiza Asma , Zemni Ramzi , Chabchoub Elyes , Gueddah Latifa , Slim Ines , Ben Hadj Slama Foued
Published: November 2017

Background:

Enteroviral infections have long been suspected in having a role in β cell destruction and therefore leading to the onset of clinical type 1 diabetes (T1D). The frequency of enterovirus (EV)-related T1D in North Africa is still unknown. The aim of the present study was to investigate the relationship between infection with EV and T1D in Tunisia.

Methods:

A total of 95 T1D patients (41 children and 54 adults) and 141 healthy control subjects (57 children and 84 adults) were tested for the presence of EV-RNA by a highly sensitive nested reverse transcription-polymerase chain reaction (RT-PCR) method.

Results:

EV-RNA was detected more frequently in plasma from diabetic patients than in plasma of controls (31.6% vs. 7.8%, p<0.0001; OR=5.45; 95% CI 2.44–12.43). RT-PCR revealed positive in 53.7% of T1D children and 14.8% of T1D adults. There was a statistically significant difference between children and adults with T1D (p<0.0001). Positivity of EV-RNA according to the time after the occurrence of the disease did not show any significant difference (p=0.34). Anti-glutamic acid decarboxylase (GAD) antibodies were not associated with EV-RNA (p=0.65).

Conclusions:

EV-RNA is associated with T1D mellitus in the Tunisian population especially in children. These results support the hypothesis that EV act as environmental risk factors for T1D.
How often are clinicians performing genital exams in children with disorders of sex development?
Authors: Tica Stefani S. , Eugster Erica A.
Published: November 2017

Background:

We sought to determine the frequency with which genital exams (GEs) are performed in children with disorders of sex development (DSD) and ambiguous genitalia (AG) during routine visits to the pediatric endocrine clinic.

Methods:

Medical records of children with DSD and AG seen at one large academic center since 2007 were reviewed. Data analyzed included diagnosis, sex of rearing, age, initial or follow up visit, number of individuals present and sex of the pediatric endocrinologist. Repeated measures analysis was performed to evaluate associations between GEs and patient/physician factors.

Results:

Eighty-two children with DSD and AG who had a total of 632 visits were identified. Sex of rearing was female in 78% and the most common diagnosis was congenital adrenal hyperplasia (CAH) (68%). GEs were performed in 35.6% of visits. GEs were more likely in patients with male sex of rearing (odds ratio [OR] 17.81, p=0.006), during initial vs. follow-up visits (OR 5.99, p=0.012), and when the examining endocrinologist was female (OR 3.71, p=0.014). As patients aged, GEs were less likely (OR 0.76, p<0.0001).

Conclusions:

GEs were performed in approximately one-third of clinic visits in children with DSD and AG. Male sex of rearing, initial visits and female pediatric endocrinologist were associated with more frequent GEs.
A newborn with combined pituitary hormone deficiency developing shock and sludge
Authors: Ueda Yasuhiro , Aoyagi Hayato , Tajima Toshihiro
Published: November 2017

A male neonate was born at 41 weeks of gestation with a birth weight of 3320 g. Artificial respiratory management was required due to respiratory disturbance 1 h after birth, and subsequently catecholamine-refractory low cardiac output-induced shock occurred. Severe combined pituitary hormone deficiency (CPHD) was considered based on the presence of his respiratory disturbance, hypoglycemia and micropenis. After hydrocortisone (HDC) administration, circulatory dynamics rapidly improved. Brain magnetic resonance imaging (MRI) showed aplasia of the anterior pituitary gland and ectopic posterior gland. γ-Glutamyltranspeptidase (γ-GTP) increased from day 10 after birth and direct bilirubin increased from day 18. On ultrasonography, sludge filling the common bile duct and gall bladder was observed. After initiating treatment with both ursodeoxycholic acid and recombinant human growth hormone (rhGH), cholestasis improved and the sludge disappeared at 3 months after birth. In newborns with CPHD, severe central adrenal insufficiency might induce cardiogenic shock after birth. Early diagnosis and intervention are necessary.
The use of a radiolucent template to improve bone age X-ray quality (BASIC study)
Authors: Cockill Toby G. , Hewitt Amanda , Heafey Christopher , Wright Neil P. , Elder Charlotte J.
Published: November 2017

Background:

Left hand and wrist X-rays are conventionally used to assess skeletal maturity using methods such as Tanner-Whitehouse 3 (TW3). We noted a number were poor quality, caused by difficulty with hand placement. We introduced a simple radiolucent hand template to assist in hand positioning and assessed changes in X-ray quality and repeat X-ray rates.

Methods:

The position of fingers, thumb and overall clarity of bone age X-rays were prospectively scored. In the absence of a validated tool to assess quality a 1–3 scale (poor, borderline, good) was devised. A radiolucent hand template was introduced for use in the intervention group. Need for repeat X-ray was determined by set criteria.

Results:

The intervention improved scores. More patients scored 3 (good) for positioning of fingers (89.29% and 85.33%, p=0.38), thumb (98.21% and 89.96%, p=0.06) and overall clarity (76.79% and 70.27%, p=0.41) for the intervention (n=56) and control groups (n=259), respectively. No patient required repeat X-ray from the intervention group, compared with 28 in the control group (p=0.007).

Conclusions:

Achieving good quality bone age X-rays is more difficult than previously assumed. The use of a radiolucent hand template has been shown to improve hand position and significantly reduce the need for repeat X-ray.
Identification of a novel mutation of NR0B1 in a patient with X-linked adrenal hypoplasia and symptomatic treatment
Authors: Yang Jing , Lv Yuncheng , Zhou Ye , Xiao Xinhua
Published: November 2017

Background:

X-linked congenital adrenal hypoplasia (X-linked AHC) is characterized by acute onset of primary adrenal insufficiency in infancy or early childhood and hypogonadotropic hypogonadism (HH) at puberty. Mutations in

Methods:

The entire coding region of the

Results:

DNA sequencing revealed a missense mutation (c.383-384 insA) in exon 1, which resulted in a novel frameshift mutation, thereby resulting in a truncated protein (p.Leu129 Pro fs*137). The therapeutic trail with an observation period of 20 weeks showed an effective improvement in symptoms of hypogonadism with human chorionic gonadotropin (HCG) administration, including a rapid improvement of serum testosterone level, descending of testicles as well as enlargement of testicles and growth of penis.

Conclusions:

Our study identified a novel frameshift mutation of the
Higher phthalate concentrations are associated with precocious puberty in normal weight Thai girls
Authors: Srilanchakon Khomsak , Thadsri Thawiphark , Jantarat Chutima , Thengyai Suriyan , Nosoognoen Wichit , Supornsilchai Vichit
Published: November 2017

Background:

The cause of precocious puberty may be associated with genetics and other conditions such as central nervous system (CNS) insults, or the exposure to endocrine disrupting chemicals (EDCs). Phthalates is known to be one of the EDCs and have estrogenic and antiandrogenic activities, and may be associated with advanced puberty. The objective of the study was to determine the association between urinary phthalate metabolites and advanced puberty.

Methods:

A cross-sectional study was conducted in patients with precocious puberty (breast onset <8 years, n=42) and early puberty (breast onset 8–9 years, n=17), compared to age-matched controls (n=77). Anthropometric measurements, estradiol, basal and gonadotropin releasing hormone (GnRH)-stimulated follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels, uterine sizes, ovarian diameters and bone ages (BA) were obtained. Urine samples were collected and mono-methyl phthalate (MMP) and mono-ethyl phthalate (MEP) were analyzed by high performance liquid chromatography (HPLC) and adjusted with urine creatinine.

Results:

The median adjusted-MEP concentration in girls with precocious puberty, was greater than in normal girls (6105.09 vs. 4633.98 μg/g Cr: p<0.05), and had the same trend among early puberty and normal puberty (5141.41 vs. 4633.98 μg/g Cr: p=0.4), but was not statistically significant.

Conclusions:

Precocious puberty girls had an association with increased MEP concentration. This is the first report of the association between urinary phthalate levels and precocious puberty in Thai girls.
Serum progranulin levels in relation to insulin resistance in childhood obesity
Authors: Alissa Eman M. , Sutaih Rima H. , Kamfar Hayat Z. , Alagha Abdulmoeen E. , Marzouki Zuhair M.
Published: November 2017

Background:

Progranulin is an adipokine that is involved in the inflammatory response, glucose metabolism, insulin resistance, and may therefore be involved in chronic subclinical inflammation associated with the pathogenesis of childhood obesity. We aimed to investigate the association of circulating progranulin levels with metabolic parameters in children and to assess the importance of progranulin as a biomarker for metabolic diseases.

Methods:

A total of 150 children were consecutively recruited from the Pediatric Nutrition Clinics at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Children were classified into four groups based on quartile for serum progranulin. Anthropometric variables were measured in all study subjects. Fasting blood samples were collected for measurement of blood glucose, insulin and lipid profile.

Results:

Children within the upper quartile for serum progranulin concentration were heavier, more insulin resistant and had higher concentrations of serum total cholesterol, triglycerides, insulin and high sensitivity C reactive protein compared to those in the lower quartile. On correlation analysis, serum progranulin concentrations were significantly related to general and central adiposity, metabolic parameters, markers of inflammation and insulin resistance. Stepwise multiple regression showed that 26.6% of the variability in serum progranulin could be explained by measures of adiposity.

Conclusions:

The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.
Zwei Formen des Ästhetischen, zwei Formen des Alltagsbezugs
Authors: Feige Daniel Martin
Published: November 2017

Der Beitrag zielt auf eine Unterscheidung von zwei Formen des Alltagsbezugs im Ästhetischen. Unter Rückgriff auf Motive vor allem der Ästhetiken Adornos und Hegels argumentiert er dafür, dass wir den Alltagsbezug der Kunst vom Alltagsbezug des Designs kategorial unterscheiden sollten. Ist Design aufgrund der Tatsache, dass es in unserer Praxis bestimmte Funktionen erfüllt, von jeher auf unsere alltägliche Praxis bezogen, stellt die Kunst einen Bruch mit dieser Praxis dar. Der Beitrag zeigt jedoch zugleich, dass daraus nicht folgt, dass Kunst nicht auch auf unsere alltägliche Praxis rückwirken würde: Sind Kunsterfahrungen performative Transformationen unserer selbst, so formen und bestimmen sie die Praxis derjenigen, die sie machen.
Ästhetik der Anwendung: Thesen zur gegenwärtigen Relation von Theater und Alltag
Authors: Warstat Matthias
Published: November 2017

Das Verhältnis von Theater und Alltag ist heute im Wandel begriffen. Als Ereigniskunst ist das Theater mit seinen Praktiken des Hervorhebens und Zeigens traditionell um Außeralltäglichkeit bemüht: Es will seinem Publikum etwas Besonderes bieten, das aus den Routinen des Alltags herausragt. Von daher besteht eine Art natürlicher Distanz zwischen Theater und Alltag, die aber überbrückt werden kann und historisch von vielen (etwa sozialrealistischen oder dokumentarischen) Theaterformen auch schon in Frage gestellt oder überwunden wurde. In jüngster Zeit, so die These dieses Beitrags, ist in verschiedenen Regionen und Bereichen von Theater eine neue, entschiedene Hinwendung zum Alltag feststellbar. Diverse Theaterformen sind nicht nur selbst auf Alltagstauglichkeit ausgerichtet, sondern sollen in den Alltag breiter Bevölkerungsschichten aktiv intervenieren. Dies gilt insbesondere für jene vielfältigen Formen, die unter den Sammelbegriff ‚Applied Theatre‘ gefasst werden. Applied Theatre verändert die globale Theaterlandschaft im großen Stil und mit ambivalenten Folgen, die gerade in der Relation von Theater und Alltag besonders auffallen. Wenn Theater in die Routinen des Alltags eingreift, stellen sich ethische, politische und ästhetische Fragen, die in diesem Beitrag erörtert werden.
Verstrickungen zwischen Alltag und Kunst: (Inter)kulturelles Potenzial oder Beschränkung ästhetischer Freiheit?
Authors: Heinicke Julius
Published: November 2017

Der Beitrag betrachtet die ambivalente Situation im rezenten deutschsprachigen Theater, auf der einen Seite auf die Tradition ästhetischer Autonomie zu pochen und auf der anderen Seite den vielfachen Forderungen Tribut zu zollen, die Erfahrungswelten von im Theater bislang marginalisierten Gruppierungen abzubilden, was häufig damit einhergeht, dass auf SchauspielerInnen und RegisseurInnen zurückgegriffen wird, welche leibhaftig diese Alltagserfahrungen repräsentieren. Ein Weg aus diesem Dilemma verspricht der Blick auf südafrikanische Produktionen, welche Impulse für Überlegungen zu einer Ästhetik geben, die abendländisch-europäische Vorstellungen, wie sie u. a. Christoph Menke entwickelt, mit Diskursen aus dem afrikanischen Kontext, die u. a. Achille Mbembe jüngst vorgestellt hat, zu verknüpfen vermag.
Vom Reiz des Immersiven
Authors: Kolesch Doris
Published: November 2017

Am Beispiel immersiver Situationen untersucht der Beitrag Verflechtungen zwischen alltäglichen ästhetischen Formationen und performativen Künsten. Denn sowohl in der Theater- und Performancekunst als auch in einem weiten Spektrum von Arbeits-, Konsum- und Erlebniswelten gewinnt Immersion als Erfahrung der Verflüssigung von Grenzen und Räumen zunehmend an Bedeutung. Der Text charakterisiert wesentliche Aspekte immersiver Theaterformen, erläutert kritisch etablierte Konzepte von Immersion und zeigt am Beispiel des Smartphone- und Tabletspiels Pokémon Go das Eindringen des Immersiven in den mediatisierten Alltag. Abschließend wird die seismografische Signifikanz des Immersiven für die Gegenwart reflektiert, insofern Immersion ein neues epistemologisches Verständnis von Subjekt und Welt sowie einen neuen Zugang zu ihr anzuzeigen scheint.
SIGNAs ganz normaler Wahnsinn
Authors: Kalu Joy Kristin
Published: November 2017

Der Artikel ist der Inszenierung und Evokation von Alltäglichkeit in der Theater-Installation Ventestedet von SIGNA gewidmet, einem partizipativen Klinik-Setting, in dem die ZuschauerInnen zu PatientInnen werden und sich einer Reihe von medizinischen und psychologischen Tests und Übungen aussetzen. In meiner Analyse des immersiven Settings fokussiere ich das Eintauchen von DarstellerInnen und BesucherInnen in ihre Rollen. Trotz aller Unterschiede dominiert in beiden Fällen ein Modus der Verkörperung, der zur strategischen Hervorbringung spezifischer Alltäglichkeit führt. Die resultierende Spielform untersuche ich als Rollenspiel, das die BesucherInnen für den kommenden außertheatralen Alltag konditioniert und dabei Parallelen zu Verfahren des angewandten Theaters aufweist.
Performing Diaries
Authors: Czirak Adam
Published: November 2017

Der Aufsatz öffnet den Blick auf die globale Landkarte der Performancekunst und zeichnet Korrespondenzen zwischen Künstlerinnen und Künstlern, die in unterschiedlichen diktatorischen oder ideologisch unterdrückenden Regimen des 20. Jahrhunderts die Medialität der Performance in der Logik einer notorischen Repetition gedacht und als tagtägliches Geschäft praktiziert haben, um ihre soziale Gegenwart zu einer alternativen Zeit- und Seinsdimension auszuweiten. Mit Hilfe ihrer Persistenz auf das Wiederholen des Vergänglichen haben Song Dong aus Peking, Ana Mendieta aus Kuba und Endre Tót aus Ungarn nicht nur ungewöhnliche Tagebuchformate entworfen, sondern durch die langjährigen Reminiszenzen einer künstlerischen Beschäftigung (in Schrift, in ephemerem Bild und in Zahl) ihren Alltag auch radikal verändert.
Der Ausnahmezustand und die Metrik des Alltäglichen
Authors: Ralfs Sarah
Published: November 2017

Der Beitrag widmet sich dem Tagebuch einer Krebserkrankung: So schön wie hier kanns im Himmel gar nicht sein! von 2009 des ein Jahr später verstorbenen Künstlers Christoph Schlingensief und untersucht dessen hiesige Alltagsdarstellung in der Ausnahmesituation der schweren Krankheit und der Konfrontation mit dem Tod. Die alltäglichen Notate oszillieren, so möchte ich zeigen, zwischen einer Emphase des Alltäglichen und den permanenten Einbrüchen der kleineren und größeren erlebten und empfundenen Katastrophen. Aus den Wechseln und Schwankungen zwischen Alltäglichkeit, Routine und deren Unterbrechungen durch das ‚Katastrophische‘ eröffnet sich eine Metaebene des Alltäglichen, die sich gerade in jenen Schwankungen und Unterbrechungen des Alltäglichen, in dessen Störung entfacht.
Sozialkünstlerisches Handeln zwischen Alltag und Performancekunst
Authors: Hinz Melanie
Published: November 2017

Der Beitrag geht anhand zweier Projekte der Frl. Wunder AG der Frage nach, wie Alltagshandeln in künstlerischen Prozessen der Performancekunst ästhetisch untersucht und künstlerisch eingesetzt wird. Während in der ethnografischen Recherche zur Stückentwicklung von Ein Bankett für Tiere (2012) Alltagspraktiken und -räume selbst zu ästhetischen Erfahrungen führen, fallen in der Stadtintervention Pimp my Town (2006) künstlerisches und alltägliches Handeln ineinander. Diese Wechselseitigkeit von Alltag und Kunst wird mit dem Begriff des sozialkünstlerischen Handelns als Ineinandergreifen von ästhetisch-leiblichen Erfahrungsräumen, Kunstproduktion und sozialer Teilhabe beschrieben.
If you don’t organize yourselves, you will be organized
Authors: Rittberger Kevin
Published: November 2017

Im vorliegenden Text versucht der Autor, die Kybernetisierung des Alltags innerhalb der Theaterinstallation Syntegrity zu beschreiben. Anhand der ästhetischen Umsetzung einer Kultur der Commons geht es darum zu untersuchen, wie die performative Vorwegnahme eines künftigen Alltags mit den Begriffen Präfiguration und Vorahmung beschrieben werden kann. Die zentralen Konzepte der Selbstorganisation und Selbstverwaltung bilden die diskursive Grundlage einer gemeinsamen Arbeit am Skript, das (nur) inmitten der technologisch-materiellen Umgebung des Labors entstehen kann. WissenschaftlerInnen, AktivistInnen, KünstlerInnen, AutorInnen und PerformerInnen können so bereits bestehende Forschungsprojekte nutzen, um künftigen Alltag mittels performativer Vorahmung als grundlegend andere Praxis erscheinen zu lassen.
Grenzgänger der Kunst: Die Sammlung als plurales Medium in der künstlerischen Praxis von Jonathan Meese
Authors: Le Calvé Maxime
Published: November 2017

Die ethnografische Beobachtung, auf der diese Fallstudie basiert, ist Teil einer im Atelier des Künstlers Jonathan Meese durchgeführten Langzeitstudie. Über den Zeitraum von zwei Jahren habe ich den Alltag des Teams von Jonathan Meese als teilnehmender Beobachter begleitet und konnte mich langsam mit den Arbeitsweisen vertraut machen, die das Kollektiv definieren. Ich wurde schließlich als zuverlässig genug erachtet, um gewisse Aufgaben zu übernehmen, und wichtiger noch, um über die Arbeit zu berichten.

Dieser Ansatz folgt einer von Tim Ingold (2013) vorgeschlagenen Haltung und zugleich der pragmatischen Schule der französischen Sozialwissenschaften, die Bruno Latour in seinem Buch Changer de société, refaire de la sociologie (2007) zusammengefasst hat.

Um Aufträgen von Galerien und Museumsinstitutionen nachzukommen, treten der Künstler und sein kleines Team von AssistentInnen mit in seinem Atelier vorhandenen Dingen in Interaktion, um sie zu Kunstobjekten werden zu lassen. Die dynamische Beziehung zwischen den zwei gegensätzlichen Perspektiven von statischem ‚Objekt‘ und fließendem ‚Ding‘ steht im Zentrum des Alltags des Teams von Jonathan Meese. Sie ist Gegenstand von Verhandlungen, Rechtfertigungen und permanenten Meinungsverschiedenheiten im Fluss der kollektiven kreativen Tätigkeit. In diesem Beitrag wird es speziell um eine in situ-Installation gehen, die aus Anlass einer Gruppenausstellung vom 28.06. bis zum 05.10.2014 im Museum für Moderne Kunst in Herford entstand. Das Fallbeispiel gibt Gelegenheit, die verschiedenen Akteure dabei zu beobachten, wie sie Passagen zwischen Ding und Objekt entstehen lassen.
Parasitierende Ordnungen
Authors: Aggermann Lorenz
Published: November 2017

Der Artikel geht der (Un)Ähnlichkeit von Ästhetik und Kulinarik nach. Obgleich die zentralen Mechanismen und Operationen der ästhetischen Ordnung (Symbolisierung, Inszenierung) auch in der Kulinarik eine fundamentale Rolle spielen und sich die Kunst gerne das soziale Kalkül der kulinarischen Ordnung (Nomos) zunutze macht, so wird bereits durch einen rudimentären Verweis auf den Begriff Geschmack deutlich, dass Ästhetik und Kulinarik bei aller Nähe mit unterschiedlichen Konzeptionen von Mehrwert und Nährwert rechnen. Anhand zweier Beispiele, der Einladung des Haubenkochs Ferran Adrià zur documenta 12 sowie der Inszenierung Hausbesuch Europa von Rimini Protokoll, erweist sich darüber hinaus, dass in der kulinarischen Ordnung ein utilitaristisches Prinzip dominiert, welches die ästhetische Setzung einer l’art pour l’art konterkariert und dem Einsatz von Essen im Rahmen der Kunst eine aporetische Note gibt.
Alltag als Partner: Das relativ unverbindliche Theater von Takuya Murakawa
Authors: Eikels Kai van
Published: November 2017

Der japanische Autor und Regisseur Takuya Murakawa bittet in Everett Ghost Lines Bekannte und Unbekannte brieflich, an einem bestimmten Tag zu einer bestimmten Uhrzeit in ein Theater zu kommen, um dort jeweils eine Handlung zu vollziehen, die sein Skript für einen Part vorsieht. Die Vorstellung beginnt in jedem Fall wie geplant. Die Angefragten tauchen auf und performen – oder nicht. Murakawa erprobt auf diese Weise, wie man mit den relativ unverbindlichen Beziehungen, die den alltäglichen Umgang in einer liberalen Gesellschaft prägen, eine kollektive künstlerische Arbeit verwirklichen kann. Sein Ansatz zeigt eine Alternative sowohl zur souveränen Macht, die Theater im Akt des Besetzens aufruft, als auch zum sozio-ökonomischen Management des Networking, das persönliche Affekte instrumentalisiert, um ‚freie‘ Kooperationen verpflichtend zu machen.