bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Realization of Fully Automatic Pump Performance Test System
Authors: Li Qi , Wu Deng Hao , Yang De Zhi , Fei Ming Hao , Song Yu , Liu Yan
Published: May 2024

With the development of automation technology, it gradually replaces manual labor in various fields. Pumps are widely used in various production processes in the industrial field. To enhance the automation level of the pump production and testing process will significantly reduce production costs. This paper aims to design and realize a set of fully automatic, high-precision pump performance testing system. The fully automated operation of the performance test is designed according to the flow rate automatic sampling method, to achieve the accurate measurement of the pump operating conditions. Utilizing the PID algorithm, the valve is automatically adjusted through PLC control to realize the accurate positioning of the flow measurement point. With the help of the software program to carry out the calculation and analysis of test data, to achieve the visualization of the test process of the whole performance test data management. At the same time, SQL Server database is used to realize rapid query and management of test data. After the test verification, the system realizes the full-automatic measurement of the pump performance curve, and the measurement accuracy conforms to the standard of ISO 9906:2012.
Effect of Calcium Carbonate as Filler on the Physicomechanical Properties of Polypropylene Random
Authors: Chakir Afaf , Alami Mohammed , Assouag Mohammed , Noureddine Othmane , Elamarty Fahed
Published: May 2024

To minimize the cost of production and enhancement pipe quality, this research aims to gain insights into the physical and mechanical characteristics of high-performance polypropylene random filled with rigid inorganic calcium carbonate particles at various content levels, with a specific focus on how the toughness of PPR changes. Virgin Polypropylene Random PPR, a new material extracted from a homopolymer polypropylene, is used as a matrix with 10, 20, 30, 40, and 50 wt. % of CaCO3. The density, melt flow rate, tensile strength, tensile strain, modulus of elasticity, and hardness are used to evaluate the quality of the material. The results showed that the density, the modulus of elasticity, and the hardness increased with increasing the percentage of CaCO3. As the percentage of CaCO3 increased, the melt flow rate decreased. The tensile strength and strain increased to 28.7 MPa and 533.25%, respectively at 20 wt.% of CaCO3, with 14.8% and 6.65% reaching gains compared to the virgin PPR (25 MPa and 500%). The enhancement of the mechanical properties is thanks to the presence of stiffer and rigid particles of CaCO3 that act as a reinforcing agent. Moreover, when CaCO3 is well dispersed, it forms a strong bond with the polypropylene matrix, and facilitates the transfer of stress from the matrix to the fillers, resulting in increased stiffness. The optimum percentage of CaCO3 to add into the inner layer of extruded PPR pipes is at a composition of the filler of 20 wt. %.
Quantification of Bed Load Transport in the Northern Part of the Central Plateau of Morocco: Case of Wadi Skhirate
Authors: Achiban Hassan , Achiban Hamid , Taous Ali , Addou Rachid , Mansouri Ismail
Published: May 2024

Rivers play a vital role in our ecosystems, providing fresh water, supporting rich biodiversity, and contributing to human well-being. However, in the face of climate change and intensive human activities, the sediment load in rivers can reach critical levels, presenting a complex set of challenges that require immediate action. The increased sediment load can alter aquatic habitats, clog channels, reduce reservoir storage capacity, and increase the risk of flooding. These direct threats entail high costs in terms of material and ecological damage, loss of life, and expenditure on rebuilding damaged infrastructure. The quantification of bedload in watercourses is therefore crucial for maintaining water and soil resources, safeguarding riparian communities, and preserving ecological balance. The study reports the findings of a three-year monitoring of the bed load of Skhirate Wadi, a river that drains a part of the western Moroccan Meseta. The study used the colorimetric monitoring method, which quantifies the volumes of coarse sediment that were transported by monitoring topographic variations in the riverbed and measuring the distances covered by the sediment. The study showed the sediment was found to move around seven times annually on average. However, the frequency and magnitude of floods and the size of particles affect the variation in this displacement. It also showed sediments travel an average distance ranging from 649 to 883 meters per year, and that the average specific bedload at the watershed scale is 30 m3/ Km2/ year. Relationships between flood peaks mobilized sediment volumes, and average particle distances are established and discussed. These results are fundamental to understanding of coarse sediment transfer processes in the small rivers of the central plateau. They are also essential for assessing the impact on the aquatic ecosystem, on downstream dams, and on the various existing road and hydro-agricultural infrastructures. This assessment will enable the implementation of appropriate management strategies to anticipate changes and plan the planning of the river and its watershed.
Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study
Authors: Kim Hyung Jun , Lee Hyung-Woo , Kang Min-Kyoung , Leem Gwang Hyun , Kim Min-Ho , Song Tae-Jin
Published: May 2024

Background: We investigated the association between body composition changes and new-onset diabetes mellitus (DM) development according to the body mass index (BMI) in a longitudinal setting in the general Korean population.Methods: From 2010 to 2011 (1st) and 2012 to 2013 (2nd), we included 1,607,508 stratified random sample participants without DM from the National Health Insurance Service-Health Screening dataset of Korean. The predicted appendicular skeletal muscle mass index (pASMMI), body fat mass index (pBFMI), and lean body mass index (pLBMI) were calculated using pre-validated anthropometric prediction equations. A prediction equation was constructed by combining age, weight, height, waist circumference, serum creatinine levels, alcohol consumption status, physical activity, and smoking history as variables affecting body composition.Results: Decreased pASMMI (men: hazard ratio [HR], 0.866; 95% confidence interval [CI], 0.830 to 0.903; P<0.001; women: HR, 0.748; 95% CI, 0.635 to 0.881; P<0.001), decreased pLBMI (men: HR, 0.931; 95% CI, 0.912 to 0.952; P<0.001; women: HR, 0.906; 95% CI, 0.856 to 0.959; P=0.007), and increased pBFMI (men: HR, 1.073; 95% CI, 1.050 to 1.096; P<0.001; women: HR, 1.114; 95% CI, 1.047 to 1.186; P=0.007) correlated with the development of new-onset DM. Notably, only in the overweight and obese BMI categories, decreases in pASMMI and pLBMI and increases in pBFMI associated with new-onset DM, regardless of gender.Conclusion: Decreased pASMMI and pLBMI, and increased pBFMI with excess fat accumulation may enhance the risk of newonset DM. Therefore, appropriate changes in body composition can help prevent new-onset DM.
Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea
Authors: Kim Byung-Joon , Shin Jun-Seop , Min Byoung-Hoon , Kim Jong-Min , Park Chung-Gyu , Kang Hee-Jung , Hwang Eung Soo , Lee Won-Woo , Kim Jung-Sik , Kim Hyun Je , Kwon Iov , Kim Jae Sung , Kim Geun Soo , Moon Joonho , Shin Du Yeon , Cho Bumrae , Yang Heung-Mo , Kim Sung Joo , Kim Kwang-Won
Published: May 2024

Background: Islet transplantation holds promise for treating selected type 1 diabetes mellitus patients, yet the scarcity of human donor organs impedes widespread adoption. Porcine islets, deemed a viable alternative, recently demonstrated successful longterm survival without zoonotic risks in a clinically relevant pig-to-non-human primate islet transplantation model. This success prompted the development of a clinical trial protocol for porcine islet xenotransplantation in humans.Methods: A single-center, open-label clinical trial initiated by the sponsor will assess the safety and efficacy of porcine islet transplantation for diabetes patients at Gachon Hospital. The protocol received approval from the Gachon Hospital Institutional Review Board (IRB) and the Korean Ministry of Food and Drug Safety (MFDS) under the Investigational New Drug (IND) process. Two diabetic patients, experiencing inadequate glycemic control despite intensive insulin treatment and frequent hypoglycemic unawareness, will be enrolled. Participants and their family members will engage in deliberation before xenotransplantation during the screening period. Each patient will receive islets isolated from designated pathogen-free pigs. Immunosuppressants and systemic infection prophylaxis will follow the program schedule. The primary endpoint is to confirm the safety of porcine islets in patients, and the secondary endpoint is to assess whether porcine islets can reduce insulin dose and the frequency of hypoglycemic unawareness.Conclusion: A clinical trial protocol adhering to global consensus guidelines for porcine islet xenotransplantation is presented, facilitating streamlined implementation of comparable human trials worldwide.
Interictal Dysfunctions of Attention, Vigilance, and Executive Functions in Migraine and Their Reversal by Preventive Treatment: A longitudinal Controlled Study
Authors: Chowdhury Debashish , Datta Debabrata , Mundra Ankit , Duggal Ashish , Krishnan Anand
Published: May 2024

Objective:

To assess attention, vigilance, and executive functions in migraine patients during headache-free (interictal) periods and in healthy controls without migraine and to study the impact of migraine preventive treatment on these cognitive functions.

Methods:

Preventive drug-naive migraine patients, aged ≥18 years, without a history of medication overuse were studied and compared to non-migraine controls. Psychiatric comorbidity was screened by Patient Health Questionnaire-9, and those who screened positive were evaluated further by specific scales. The Epworth Sleepiness Scale assessed subjective complaints of sleep quality. Cognitive functions were assessed by Mini-Mental State Examination (MMSE), digit span forward and backward (DS-F, DS-B), trail-making tests (TMT-A and B) and Stroop word (SW), Stroop color (SC), and Stroop interference (SI) tests. Cognitive test scores at the end of 6 months following treatment were compared to baseline scores.

Results:

One hundred and fifty migraine patients and controls each were studied. Compared to controls, migraine patients performed significantly worse in DS-B (P < 0.0001), TMT-A (P = 0.00004), TMT-B (P < 0.0001), SW (P < 0.0001), SC (P < 0.0001), and SI (P = 0.0221). MMSE scores did not differ between patients and the controls (P = 0.3224). Compared to the patients without psychiatric comorbidity, migraine patients with psychiatric comorbidity showed no significant differences in the cognitive test scores. Significant improvement in all cognitive test scores (P < 0.001) was observed after 6 months of treatment.

Conclusion:

Migraine patients, compared to non-migraine controls, showed deficits in attention, vigilance, and executive functions during the interictal period, which improved with successful preventive treatment. Psychiatric comorbidities did not have a significant impact on cognitive dysfunctions.
Evaluation and isolation of anti-cancer compounds from the endophytic fungus Penicillium funiculosum isolated from Persicaria salicifolia (Brouss. Ex Willd.) seeds growing in Egypt
Authors: Amer Asmaa A. , Hegazy Mostafa M. , Zhran Monira , Elhosainy Asmaa , Safwat Nesreen A , El-Hela Atef
Published: May 2024

Background

The endophytic fungus Penicillium is an important source of natural bioactive products. Persicaria salicifolia (Brouss. ex Willd) (family Polygonaceae) is a widely distributed plant on the Nile River and was reported to have several biological activities, such as antioxidative, antibacterial, and anti-inflammatory effects.

Objective

This study aimed to explore the potential activities (cytotoxic, anti-oxidant, and anti-microbial) of the endophytic fungus Penicillium funiculosum isolated from Persicaria salicifolia seeds growing in Egypt.

Materials and methods

The endophytic fungus Penicillium funiculosum was isolated from the seeds of the Persicaria salicifolia plant. The fungi were grown on Basmati rice as a solid media for the enhancement of pure fungi production. The collected fungi were extracted with ethyl acetate and fractionated using n-hexane and methanol. All fractions were examined for their cytotoxic, antioxidant, and antimicrobial activities. The secondary metabolites were isolated from the active fractions through column chromatography, and the isolated compounds were identified by spectroscopic technique. Molecular docking analysis was applied to the isolated compounds.

Results and conclusion

Ethyl acetate extract (Pf-2) of P. funiculosum was proved to have a highly potent antioxidant (IC50 37.5±0.70 μg/ml) and cytotoxic effects. It was affected on hepatic cancer (HepG-2), human colon carcinoma (HCT-116), lung carcinoma (A-549), and human breast cancer (MCF-7) cells with IC50 values (μg/ml) 4.26±0.2, 6.66±0.9, 9.36±0.3, and 9.41±0.7, respectively. Pf 2 was subjected to fractionation, resulting in four fractions (Pf 2–1 to Pf 2–4). The most potent cytotoxic fraction, Pf 2–2, was further fractionated into six sub-fractions: Pf 2–2 A to Pf 2–2 F. Pf 2–2 A possessed the most potent cytotoxic activity. The ethyl acetate extract (Pf 2) also had antimicrobial activity against gram-positive Bacillus subtilis and gram-negative bacteria (E. coli). Four compounds were isolated from Pf 2–2 A and identified by spectroscopic methods: NMR (1H and 13C) and Mass as (1) (9E, 11E, 13Z, 15Z)-tetracosa-9, 11, 13, 15-tetraenoic acid, (2) 3-(1Z, 3E-hexa-1, 3-dienyl)-4b-methyl-tetradecahydrophenanthrene, (3) mannitol, (4) d-Cerebroside A-glucose. It is the first time to report the isolation of compound (2) from the genus Penicillium and compounds (1, 3, and 4) from the species P. funiculosum. Compound 2 was the most potent cytotoxic one. Molecular docking was studied for polar compounds 1, 3, and 4 using the COX-2 enzyme, which indicated that compound 4 was the most potent anti-inflammatory one.
Meconium aspiration syndrome: An overview of the literature
Authors: Fan Hueng-Chuen , Chen Chuan-Mu
Published: May 2024

Meconium aspiration syndrome (MAS), a critical cause of morbidity and mortality in term newborns, mostly results from antepartum or postpartum aspiration of meconium-stained amniotic fluid (MSAF). The severity of MAS can vary from self-resolving to serious complications, such as persistent pulmonary hypertension or mortality. Concepts regarding pathophysiology and management have undergone drastic changes over the last few decades. For example, in both vigorous and nonvigorous neonates with MSAF, routine endotracheal suctioning during resuscitation is not recommended. There is no proven therapy for MAS; therefore, management is primarily supportive. Respiratory support, surfactant, inhaled nitric oxide, corticosteroids, and bronchoalveolar lavage significantly improved the overall outcome of MAS. This review will provide an overview of the challenges in understanding the complicated pathophysiology of MAS and optimal therapies for treating MAS.
Pemphigus and Pregnancy
Authors: De Dipankar , Shah Shikha , Mahajan Rahul , Handa Sanjeev
Published: May 2024

Pemphigus in pregnancy is a special clinical scenario that has potential consequences on both maternal and fetal outcomes. Being an autoimmune disease with Th2 preponderance, pemphigus is expected to flare in pregnancy, especially in the first two trimesters. Fetal outcomes like stillbirth and neonatal pemphigus have been reported, the latter being a consequence of a transient transplacental transfer of autoantibodies. Management needs to be individualized keeping the risk/benefit ratios of therapies in mind while optimizing maternal and fetal health. It is crucial to have appropriate counseling regarding conception for women with pemphigus in the child-bearing period because the probability of adverse materno-fetal outcomes is higher if the disease is severe.
Clinicopathologic study of caruncular lesions
Authors: Thrishulamurthy Chinmayee J , Ahmed H Shafeeq , Siddegowda Ramya B , Biligi Dayananda S
Published: May 2024

Purpose:

The caruncle is a unique anatomical site in the human body, comprising various structures derived from the surface ectoderm and mesoderm. Caruncular lesions can range from benign to malignant and present challenges in accurate diagnosis and timely management due to their hidden nature and proximity to the lacrimal sac. This study aims to provide a comprehensive description of caruncular lesions, presenting the first Indian case series on this topic.

Methods:

Ethical approval was obtained, and data collection was conducted at a tertiary care center in India. A retrospective analysis was performed on 44 patients with caruncular lesions treated between 2013 and 2020. Detailed patient histories, clinical examinations, slit lamp imaging, and excision biopsies were conducted. Histopathological examination of the specimens was carried out.

Results:

The study included 42 cases of caruncular lesions, with a mean age of 31.09 years. The majority of cases were male (54.54%). Benign lesions accounted for 84.09% of the cases, while premalignant and malignant lesions accounted for 11.36% and 4.54%, respectively. Papilloma and nevus were the most common lesions, with 11 cases each. All caruncular lesions were successfully and completely excised without complications. Histopathological examination confirmed the accuracy of the diagnoses, with an 84.09% concordance rate between clinical assessment and pathological diagnosis.

Conclusion:

This case series reveals a predominance of benign lesions among individuals in their early thirties. The successful excision of all lesions with a high concordance rate between clinical assessment and histopathological diagnosis underscores the importance of timely and accurate management.
Jejunal strongyloidiasis mimicking crohn’s colitis: A diagnostic dilemma!
Authors: Goyal Surbhi , Barman Sandip , Sakhuja Puja , Sachdeva Sanjeev , Narang Poonam , Nag Hirdaya H.
Published: May 2024

We report an unusual case of jejunal strongyloidiasis presenting as chronic malabsorption and intractable small bowel diarrhea in an immunocompetent adolescent boy who posed a diagnostic challenge for pathologists, radiologists, and gastroenterologists. Histopathology revealed chronic active colitis and was consistent with the clinicoradiological diagnosis of Crohn’s colitis but nonresponse to immunomodulators warranted full-thickness jejunal biopsy through laparotomy which showed numerous larvae and eggs of Strongyloides. There is a need to increase the awareness of Strongyloides colitis given its high rate of misdiagnosis and mortality as the correct diagnosis can avoid a fatal outcome of this curable disease.
Effect of non-thermal atmospheric pressure plasma and ErCr
Authors: Bapat Shreya Arun , Shashikiran N. D. , Gugawad Sachin , Gaonkar Namrata , Taur Swapnil , Hadakar Savita , Chaudhari Pradnya
Published: May 2024

Background:

Dental remineralization is the process of transporting minerals from the surrounding environment (i.e., saliva and biofilm) into partially demineralized tooth structures. Remineralization can be induced by professional therapies such as fluoride-based treatments that have the highest level of supporting evidence. High-intensity LASER and nonthermal atmospheric pressure plasma therapy have been known to increase the resistance of enamel to demineralization by surface modification.

Aim:

The aim of the study was to evaluate and compare the surface remineralization of enamel using ErCr:YSGG LASER and nonthermal atmospheric pressure plasma (NTP) activation with three different fluoride varnishes.

Methodology:

Sixty-eight extracted premolars were used which were sectioned mesiodistally to obtain 135 specimens and artificial caries were induced on the experimental surface. They were then randomly divided into three groups (n = 45): MI Varnish (GC Japan), Vanish Varnish (3M ESPE), and Embrace Varnish (Pulpdent). After varnish application, these groups were further divided into three subgroups based on the activation therapy used. Fifteen samples from each group were treated with ErCr:YSGG LASER, 15 samples with NTP, and 15 samples were the control that did not undergo activation. After 9 days of pH cycling, the mean ion concentration of the surface calcium and phosphate ions was recorded using FEG-SEM and EDX analysis. The data were statistically analyzed.

Results:

One-way ANOVA and post hoc Tukey test accepting P < 0.05 were performed for comparisons between all analyses groups. Vanish Varnish showed a higher Ca/P ratio in LASER, NTP, and control subgroups, followed by MI Varnish and Embrace Varnish. ErCr:YSGG LASER therapy showed an improved Ca/P ratio in all varnishes than NTP therapy and control.

Conclusion:

ErCr:YSGG LASER therapy showed positive effects toward improving the Ca/P, followed by NTP therapy as compared to control in all three varnishes indicating their role in enhancing the effects of remineralization. Vanish Varnish showed a higher Ca/P ratio indicating better remineralization post activation.
Cephalometric evaluation of the cervical spine posture following fixed functional therapy with Forsus™ appliance
Authors: Malik Nidhi , Fernandes Bennete Aloysius , Ramamurthy Priyadarshini Hesarghatta , Anjum Shagufta , Prakash Amit , Sinha Abhik
Published: May 2024

Background:

To investigate whether fixed functional therapy for mandibular advancement with the Forsus™ appliance would produce any changes in the cervical spine posture.

Materials and Methods:

This prospective clinical exploratory study was conducted on 12 patients (six females and six males) with a mean age of 15 ± 1.3 years, having mandibular retrusion, Class II malocclusion, who were treated with the Forsus™ appliance. Lateral cephalogram was taken twice, once at the baseline (T1) before the commencement of the treatment and once following termination of fixed functional treatment (T2). Eleven measurements representing the vertical and the sagittal craniofacial proportions, and the head posture, were taken into account. Data were analyzed using SPSS version 22. The variations between before and after treatment measurements were collated using paired t-test. P < 0.05 was considered statistically significant.

Results:

No significant differences were noticed in the angle linking the horizontal lines of the head and the superior crest of the spinal column before and after the treatment, with P = 0.73. The cervical curvature angle also failed to show any significant difference with P = 0.14.

Conclusion:

Fixed functional therapy with the Forsus™ device resulted in dentoalveolar and soft tissue alterations alone but did not alter the cervical spine posture.
A comparative study of conventional and Hall techniques of crown placement using finite element stress analysis
Authors: Herkar Pawan Pramodrao , Anantharaj A. , Praveen P. , Shankarappa Prathibha Rani , Sudhir R.
Published: May 2024

Background:

Hall technique of crown placement causes the changes in vertical occlusal dimension; the mode of settlement of which needs to be explored.

Aim:

To assess and compare the changing patterns of stress distribution following placement of stainless steel crowns on primary teeth by Hall and conventional techniques using a finite element model analysis.

Materials and Methods:

The clinical crown heights of primary molars restored with Hall and conventional techniques and opposing teeth in contact, vertical dimension changes in the primary canine area were measured using intraoral digital scan. T-scan was used to measure the changes in bite force while the finite element analysis was used to assess deformative changes on the 2nd, 5th, 10th, and 15th days.

Results:

The Hall technique of crown placement caused more stress distribution in the tooth supporting tissues that settled in 2 weeks as compared with conventional technique of crown placement in which settlement occurred in 2 days.

Conclusion:

The settling of vertical occlusal dimension as well as stress distribution in Hall technique probably takes place by intrusion of crowned tooth and opposing teeth in contact.
Prevalence of gingival recession and associated etiological factors among the school children
Authors: Seemakurthy Sonia Sudeepthi , Nuvvula Sailavanya , Mallineni Sreekanth Kumar , Nuvvula Sivakumar
Published: May 2024

Objective:

The objective of this study is to assess the prevalence of gingival recession (GR) and associated etiological factors among school children.

Methodology:

The study sample consisted of 2095 children from the Nellore region divided into three groups of age ranges from primary dentition (<7 years), mixed dentition (7–12 years), and permanent dentition (>12 years) respectively, attending the department of pediatric and preventive dentistry and the school dental health programs organized by the department. The clinical examination involved measuring GR using William's periodontal probe and evaluating associated etiological factors. Data were statistically analyzed using the Chi-square test.

Results:

The GR among the study population was 7.9% (n = 165). Among them, males were 46% and females were 54% (P > 0.05). The GR was more in children in the 7–12 years age group (75%), followed by <7 years (21%) and >12 years (4%) age groups. The associated factors include malocclusion (69%), deleterious habits (5%), and anomalies (26%). Anomalies showed an association with GR (P < 0.05) compared to malocclusion and deleteriousness habits (P > 0.05).

Conclusion:

The prevalence of GR is 7.9%, and GR is more prevalent in males and the 7–12 years age group. GR is associated with transient malocclusion, deleterious habits, and anomalies.
Assessment of knowledge and attitude toward informed consent and assent for biomedical research involving children among health-care professionals in Belagavi city
Authors: Patil Vidyavathi H. , Hugar Shivayogi M. , Gokhale Niraj S. , Kajjari Shweta , Saxena Nivedita , Dialani Pooja K.
Published: May 2024

Background:

Most of the nations have proposed research regulations to protect the rights and welfare of the research participants. Among such regulations are the informed consent and assent. In the present world, informed consent and assent is the cornerstone in health practice.

Aims and Objectives:

To compare and evaluate the knowledge and attitude toward informed consent and assent for biomedical research involving children among health-care professionals in Belagavi city.

Materials and Methods:

A cross-sectional questionnaire study was conducted among 300 house surgeons divided into four groups of Medical, Dental, Nursing, and Ayurveda faculty of Belagavi city. A self-administered multiple choice questions were used to evaluate the knowledge and a five-point Likert scale was used to asses attitude regarding informed consent and assent for research involving children. Statistical analysis was done using SPSS version 20.

Results:

There was statistically significant difference in mean knowledge and attitude among all four groups (P < 0.05), and there was no significant correlation between knowledge and attitude as a whole in each group of professionals (P > 0.05).

Conclusion:

Emphasis on additional training is the need of the hour for all the faculty participants and also incorporation of study material regarding informed consent and assent for research involving children by the policy makers.
Comparison of the Streptococcus mutans colony count changes in plaque following chlorhexidine (0.12%) mouth rinse and green tea extract (0.5%) mouth rinse in 8–12-year-old children
Authors: Kamath Shamika , Hegde Rahul , Kamath Narayana
Published: May 2024

Background:

Mouth rinses are solutions or liquids used to rinse the mouth to have a therapeutic effect by relieving infection or preventing dental caries due to their antimicrobial properties. Aims: This study was carried out to compare the effect of 0.12% chlorhexidine mouth rinse and 0.5% green tea extract mouth rinse on the colony-forming units (CFUs) of Streptococcus mutans in plaque in children.

Materials and Methods:

The sample for the study consisted of fifty schoolchildren aged 8–12 years with four or more (decay component) of decayed, missing, and filled teeth index. Children were divided randomly into two groups and were asked to rinse with the prescribed mouth rinse twice daily for 2 weeks under supervision. The plaque samples were collected at baseline (prerinsing) and postrinsing and tested for the CFUs of S. mutans.

Results:

The results of the study indicate that there was a statistically significant reduction (pre- and postrinsing) in S. mutans colony count in both the study groups. There was no statistically significant difference in the reduction of S. mutans colony count between 0.12% chlorhexidine mouth rinse group and 0.5% green tea mouth rinse group.

Conclusion:

Green tea mouth rinse is effective against S. mutans – one of the major dental plaque microorganisms.
Comparative evaluation of intracanal cryotherapy and curcumin as a final irrigant in reducing post endodontic pain in primary teeth
Authors: Kumari Nimisha , Kaur Harsimran , Choudhary Rishika , Yeluri Ramakrishna
Published: May 2024

Aim:

The aim of this study was to evaluate the intracanal effectiveness of cryotherapy, curcumin irrigant, and normal saline as a final irrigant in reducing postendodontic pain in primary teeth.

Materials and Methods:

A total of 120 teeth between the ages of 4 and 7 years requiring pulpectomy in primary teeth were included in the study. The teeth were randomly assigned to one of the three treatment groups: intracanal cryotherapy using 2.5°C cold saline, curcumin irrigant, or normal saline. Following completion of chemomechanical preparation, final irrigation with 2.5°C cold saline, curcumin irrigant, and normal saline solution at room temperature were employed in the groups. Participants were asked to rate the severity of their postoperative pain on the Visual Analog Scale before, immediate postoperative after wearing of local anesthetic effect, and 24 h after the procedure. The results were analyzed statistically.

Results:

The differences in reduction of postendodontic pain between the three irrigating regimens were statistically not significant. Cryotherapy utilizing 2.5°C cold saline or curcumin irrigant can be used instead of normal saline as a final irrigant in pulpectomy of primary teeth.

Conclusions:

Cryotherapy can be a straightforward, cost-effective, and nontoxic treatment option for the management of postendodontic pain. Curcumin irrigant with its anti-inflammatory properties is also a better alternative as a final irrigant for reducing postoperative pain in primary teeth.
Nanosilver fluoride as a caries arresting agent in children
Authors: Choubey Shikha , Patil Amol , Talekar Abhinav L. , Kalra Dheeraj
Published: May 2024

Background:

Dental caries is one of the most common concerns in oral health of children. Arresting these lesions is a treatment which is gaining momentum as against conventional restorative approaches.

Aim:

The aim is to evaluate the efficacy of nanosilver fluoride (NSF) as a caries arresting agent in primary teeth or first permanent molars in children.

Design:

The protocol for the systematic review has been registered with PROSPERO database (CRD42020162386). Several databases, such as PubMed®/MEDLINE, Web of Science™, Scopus®, Google Scholar, LILACS, Cochrane Library, ProQuest, and BBO, were searched for randomized controlled trials (RCTs) which evaluated the arrestment of caries, in primary teeth and first permanent molars in children, with a minimum follow-up of 6 months. The Risk of Bias tool by Cochrane reviews system software, Revman 5.4.1, was used for quality assessment of the included RCTs. The quality evaluation was done using the GRADE approach. Heterogeneity was assessed using Cochrane's Q and I2 statistics.

Results:

Five studies were included for qualitative and quantitative analysis. The Risk Ratio for NSF versus active control group was assessed to be 1.09 (0.93-1.28) with 95% Confidence Interval and for placebo control was 0.49 (0.35-0.67).

Conclusion:

NSF shows promise as a caries arrestment agent when applied in primary teeth.

PROSPERO Registration:

This review was registered with the PROSPERO database (CRD42020162386)
Effect of immunoglobulin Y formulations on oral microorganisms in human subjects - A systematic review and meta-analysis of clinical trials
Authors: Jawdekar Ashwin M , Srivastava Vatsala , Tank Urvashi , Mistry Laresh Naresh
Published: May 2024

Background:

Passive immunization using egg yolk-based antibodies has been tested against oral microorganisms. Our study assessed the effect of immunoglobulin Y (IgY) formulations on Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans in human subjects.

Highlights:

VS and UT independently searched articles using keyword combinations in four search engines; studies in English were selected. Either parallel-arm or split-mouth randomized controlled trials on healthy human subjects were considered. Ten studies remained in the selection; six studies compared the effect of IgY formulations on S. mutans, three on P. gingivalis, and one on C. albicans. Five studies (422 subjects) compared the effect of IgY formulations on S. mutans. When fixed-effect model (FEM) was applied, the risk ratio (RR) (confidence interval [CI]) was found to be 7.81 (6.00, 10.18). Three studies (167 subjects) compared the effect of IgY formulations on P. gingivalis. When FEM was applied, the RR (CI) was found to be 0.06 (−0.03, 0.15) in relation to reduction in probing depth. When FEM was applied, for percentage reduction in bleeding on probing (BOP), the RR (CI) was 1.99 (1.64, 2.41). Only one study (26 subjects) was available of IgY formulation and C. albicans; hence meta-analysis was not performed. The search was extended using Google Scholar, Semantic Scholar, cross-references and by contacting authors and researchers in the field which further yielded five articles. .

Conclusions:

IgY formulations were effective in the reduction of S. mutans. They were not effective on P. gingivalis in relation to probing depth but were effective in relation to reduction in BOP. No harms were reported. Evidence is of low quality due to high heterogeneity. The ROB was moderate and publication bias was low.
A comparative evaluation of gingival microleakage and internal voids in Class II composite restoration with two different lining techniques
Authors: Shishodia Rachana , Goyal Virinder , Shaikh Almas , Mahule Aushili , Dondani Jay
Published: May 2024

Aim:

The aim of this study was to evaluate the gingival microleakage and internal voids in Class II composite restoration restored with precure and co-cure lining techniques using stereomicroscopic method.

Materials and Methods:

Forty-five freshly extracted permanent multirooted human molar teeth were collected and used in the study. After surface debridement and scaling of all teeth, standard Class II mesio-occlusal cavities were prepared. Forty-five samples were randomly divided into three experimental groups (n = 15), and filled according to manufacturer's instructions. Group I was precure group, Group II was co-cure group, and Group III was only bulk fill. The finishing and polishing of the restorations was done after 24 h. Then, all the specimens were subjected to thermocycling for 500 cycles. The gingival microleakage and internal voids of all the groups were evaluated using dye penetration method. Samples were then sectioned and examined under the stereomicroscope at ×40. Readings obtained were subjected to statistical analysis using SPSS ver 20.0 (IBM Corp, ARMONK USA) and Chi-square test.

Results:

The statistical analysis revealed that extent of microleakage was maximum in Group II (co-cure), followed by Group III (only bulk fill) and Group I (precure). The gingival voids were maximum in Group III (only bulk fill), minimum in Group II (co-cure), and least in Group I (precure). The cervical voids were maximum in Group II (co-cure) and Group III (only bulk fill), followed by Group I (precure). The occlusal voids were maximum in Group II (co-cure) and similar in Group I (precure) and Group III (only bulk fill).

Conclusion:

The precure lining technique was better than co-cure lining technique in terms of both microleakage and internal voids.
Short- and long-term dental arch spatial changes following premature loss of primary molars
Authors: Gandhi Janvi Manish , Gurunathan Deepa
Published: May 2024

Aim:

The aim of this study was to evaluate the dental arch spatial changes in maxillary and mandibular arches after premature loss of primary molars.

Introduction:

Primary teeth must be maintained during the change from primary to mixed and then permanent dentition, to preserve and maintain the dental arch. When this normal process is disturbed, usually due to severe decay requiring extraction before normal exfoliation, it can result in migration of adjacent teeth toward the missing space resulting in decreased arch length and malocclusion in the permanent dentition.

Materials and Methods:

A comprehensive search was conducted using electronic databases such as PubMed Central, Cochrane Database of Systematic Reviews, Google Scholar, LILACS, and ScienceDirect. The title and abstract were screened to find relevant articles, which were then reviewed in full to see if they were worthy of inclusion. All longitudinal and observational studies that looked at space changes after the loss of primary first or second molars were included. Quality assessment of the studies was done based on the Newcastle-Ottawa scale as all the included studies were non-randomized studies.

Results:

Four thousand five hundred and seventy-eight articles were identified by screening electronic database and assessed for eligibility, 12 full-text articles were assessed, and 4 full-text articles were excluded as they did not match the inclusion criteria. Thus, eight articles were included in this systematic review. Short term and long term space changes and loss of maxillary and mandibular molars were studied individually. In the short term changes, the distal migration of the primary cuspid towards the missing space within 1 month was attributable to early space changes after premature loss of the mandibular first molar, and the greatest space loss was recorded in the first 3 months after premature loss. After the premature loss of the maxillary first molar, immediate space loss of 1mm was documented due to distal migration of the primary canine. Studies found that space loss was caused by the distal migration of primary canines in the case of mandibular primary first molar loss, and that space loss was larger in the mandibular arch after premature loss of second primary molars.

Conclusion:

The greatest repercussions occurred during the first 3 months after the deciduous molars were extracted, and a space maintainer was recommended in the majority of cases, mainly when there is premature loss of mandibular second primary molar as it leads to mesial displacement of the first permanent molar.
Evaluation of caries arresting potential of silver diamine fluoride and sodium fluoride varnish in primary molars
Authors: Prakash D. Kumar Mani , Vinay C , Uloopi KS , RojaRamya Kakarla Sri , Penmatsa Chaitanya , Chandana N.
Published: May 2024

Background:

Caries management in the modern era has shifted away from the traditional surgical method toward a medical paradigm, which often includes fluoride therapy. Fluoride used in various forms has been proven to be effective in dental caries prevention. Silver diamine fluoride (SDF) and sodium fluoride (NaF) varnish are effective in arresting caries in primary molars.

Aim:

This study aimed to evaluate the effectiveness of 38% SDF and 5% NaF varnish in arresting caries in primary molars.

Settings and Design:

This study was a split-mouth randomized controlled trial.

Materials and Methods:

The randomized controlled trial comprised 34 children aged 6–9 years with teeth having caries in both right and left primary molars without pulpal involvement. Teeth were randomly allocated into two groups. In Group 1 (n = 34), 38% SDF + potassium iodide was applied and in Group 2 (n = 34), 5% NaF varnish was applied. The second application was done after 6 months in both groups. Children were recalled at 6- and 12-month intervals and evaluated for caries arrest.

Statistical Analysis:

Chi-square test was used to analyze the data.

Results:

Caries arresting potential was found to be higher in the SDF group compared to the NaF varnish group at both 6-month (SDF – 82% and NaF varnish – 45%) and 12-month intervals (SDF – 77% and NaF varnish – 42%) and the difference was found to be statistically significant (P = 0.002 and 0.004, respectively).

Conclusion:

SDF was more effective in arresting dental caries in primary molars compared to 5% NaF varnish.
Apical extrusion of debris with root canal instrumentation in primary teeth
Authors: Kaushal Drishti , Reddy Srinivas Gosla , Biswas Krishna Prasad , Dixit Ashutosh , Chowdhry Rebecca , Chug Ashi
Published: May 2024

Aim:

This study aimed to systematically review available literature of in vitro studies on apical extrusion of debris through rotary instrumentation in comparison to manual instrumentation in pediatric endodontics, and also to perform a comparison between various rotary instrumentation systems for assessment of debris extrusion.

Materials and Methods:

A comprehensive search was conducted on PubMed, Medline, Cochrane Library, Embase, Scopus, and Google Scholar without any language restriction and year of publication. A planned search strategy was made for PubMed and applied to other databases. After full-text reading, 7 articles were selected for quantitative synthesis. Modified CONSORT checklist of items for reporting in vitro studies of dental materials was used for quality assessment of included studies.

Results:

Root canal preparation with rotary instrumentation led to lesser apical debris extrusion than manual instrumentation. Self-adjusting file system was associated with the least debris extrusion among all included studies, followed by ProTaper Next, Kedo-S, ProTaper, K3, Mtwo, Revo-S, and Wave One.

Conclusion:

More apical debris extrusion was seen with manual instrumentation than rotary instrumentation. Furtrhermore, variance in debris extrusion was seen with different rotary file systems.
Ego defense mechanisms among pediatric dental postgraduate students in India
Authors: Asokan Sharath , Geetha Priya P. R. , Viswanath Sudhandra , Mathiazhagan Thendral
Published: May 2024

Background:

Ego defense mechanisms (EDMs) act as a major factor for overcoming stressful situations in life.

Aims:

The study aimed to assess the various patterns and factors of EDMs employed by pediatric dental postgraduate students in India.

Settings and Design:

Cross-sectional design, web-based questionnaire survey.

Methods:

A cross-sectional questionnaire study on EDM was conducted among 246 pediatric dental postgraduates in India from July to October 2019. The modified form of the Defense Style Questionnaire-20 included 10 EDMs under three major patterns– Mature, Immature, and Neurotic. The questionnaire was sent to all pediatric dental postgraduates enrolled in the Indian Society of Pedodontics and Preventive Dentistry and reminders were sent every week for 6 weeks.

Results:

Among the 1041 pediatric dental postgraduates who received the E-mail, two hundred and forty-six students responded to the same. The respondents included 89 males and 157 females. The mature pattern was found to be the most commonly employed EDM (males-47.20%; females-51.60%). Sublimation (72.76%), a mature type of defense was found to be the most common EDM factor employed by the majority of the students. The immature pattern was higher among males when compared to females (males-14.60%; females-5.70%).

Conclusion:

Most pediatric dental postgraduates exhibited a mature pattern, followed by a neurotic and immature pattern of EDM. The mature pattern of EDM was displayed more by the female students than the male students. Sublimation was found to be the maximum expressed factor followed by acting out.
Talon's cusp in a primary maxillary central incisor
Authors: Galhotra Virat , Rao Santhosh , Goel Pallavi
Published: May 2024

Talon's cusp, a type of dens evaginatus (DE) in a primary tooth, is a rare odontogenic anomaly which is reported sparingly in the literature. We report this case describing the presence of a talon's cusp on the right primary maxillary central incisor in a 2-year-old boy precipitating discomfort, owing to occlusal interference. The treatment plan involved pulpectomy and reduction of the lingula DE extension under general anesthesia.
Evaluation of the clinical efficacy of 38% silver diamine fluoride in arresting dental caries in primary teeth and its parental acceptance
Authors: Chaurasiya Aparna , Gojanur Sushma
Published: May 2024

Background:

Early childhood caries (ECC) has been regarded as one of the most prevalent chronic diseases in children. Conventional restorative management of ECC is difficult to perform in very young and apprehensive children. Silver diamine fluoride (SDF) can be a useful tool in the management of dental caries by arresting the carious lesion in primary teeth. After SDF treatment, the dentinal staining that is associated with SDF influences the acceptance of this treatment among parents of young children.

Aim:

This study aimed to evaluate the clinical effectiveness of biannual application of 38% SDF followed by 5% sodium fluoride (NaF) varnish for arresting dental caries in children and its parental acceptance.

Methods:

Twenty-six children aged 2–5 years with 107 active caries lesions in primary teeth were enrolled. At the baseline examination, status of carious lesions was recorded and scored according to the International Caries Detection and Assessment System II. Lesion activity was assessed by visual inspection and tactile detection. Carious lesions with score 3, 4, 5, and 6 were treated with 38%SDF application, followed by 5% NaF varnish. Children were re-evaluated at 3 weeks, 3 months, 6 months, and 12 months. Parental acceptance of SDF treatment was evaluated.

Results:

This study demonstrated that 38% SDF was 92.31% effective in arresting dental caries in primary teeth and was well accepted by parents. Chi-square test was used to assess the significant difference among the arrested lesions which was statistically significant (P < 0.05).

Conclusion:

Thirty-eight percent SDF can be effectively used in arresting caries in primary teeth in young and uncooperative children.
A segmental root development as an unusual healing response to the revitalization of mandibular second premolar
Authors: Tamanna Sadaf , Rehman Aaliya , Tewari Rajendra Kumar , Mishra Surendra Kumar
Published: May 2024

A 15-year-old patient reported persistent pain in the left mandibular second premolar (#35) following a traumatic bite 3 months ago. Clinical examination revealed a fractured central cusp suggestive of dens evaginatus. Intraoral periapical radiograph revealed an immature permanent tooth with a periapical radiolucency. A diagnosis of pulp necrosis with symptomatic apical periodontitis was made. The tooth was treated according to the revised guidelines of regenerative endodontic procedure by the American Association of Endodontics. The follow-up evaluation revealed a complete resolution of periapical pathology. A detached radiopaque tissue was appreciated at the 12-month follow-up. It resembled a broken root tip at the 24-month follow-up. Both the main root body and disjointed root tip developed independently. A cone-beam computed tomography evaluation at the 36-month follow-up confirmed the segmented development of the apical root tip.