bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital Developmental Advising Systems for Engineering Students Based on Accreditation Board of Engineering and Technology Student Outcome Evaluations
Authors: Hussain Wajid , Fong Mak , Spady William G.
Published: August 2024

The purpose of this research is to examine the benefits and limitations of the implementation of novel digital academic advising systems based on the principles of authentic outcome-based education (OBE) using automated collection and reporting processes for Accreditation Board for Engineering and Technology (ABET) student outcomes data for effective developmental advising. We examine digital developmental advising models of undergraduate engineering programs in two universities that employ customized features of the web-based software EvalTools® 6.0, including an advising module based on assessment methodology incorporating the faculty course assessment report, performance indicators, and hybrid rubrics classified according to the affective, cognitive, and psychomotor domains of Bloom’s learning model. A case study approach over a six-year period is adopted for this research. The two case studies present results of samples of developmental advising activity employing sequential explanatory mixed methods models using a combination of quantitative and qualitative analyses of (a) detailed students’ outcomes and performance indicator information and (b) self-evaluation of their professional development and lifelong learning skills. The findings of this study show that digital advising systems employing the faculty course assessment report using performance indicators and hybrid rubrics can provide comprehensive and realistic outcome data to help both developmental advisors and students easily identify the specific cause of performance failures, implement practical recommendations for remedial actions, and track improvements. Inherent strong skills can also be identified in academically weak students by observing patterns or trends of relatively better-performing outcomes to reinforce their natural affinity for learning specialized competencies to help them pursue related and successful career paths.
A Treatment for Rice Straw and Its Use for Mealworm (Tenebrio molitor L.) Feeding: Effect on Insect Performance and Diet Digestibility
Authors: Saura-Martínez Jorge , Montalbán Ana , Manzano-Nicolás Jesús , Taboada-Rodríguez Amaury , Hernández Fuensanta , Marín-Iniesta Fulgencio
Published: August 2024

The development of reuse processes for plant by-products for both animal and human food offers numerous possibilities for quality-of-life improvements that align with a circular economy model. For this reason, we divided this study into two experiments. First, we designed a combined treatment consisting of laccase, ultrasound, and ascorbic acid to hydrolyze rice straw plant fibers and used the resulting feed as the basis for T. molitor diets. Second, we formulated diets with different inclusion levels (0%, 25%, 50%, 75%, and 100%) of rice straw and treated rice straw to assess their impact on larvae growth and diet digestibility. For each treatment, six replicates were employed: four for the growth–performance–digestibility trial and two for complementary uric acid determination tests. The combined laccase enzyme, ultrasound, and ascorbic acid treatment hydrolyzed 13.2% of the vegetable fibers. The diets containing treated rice straw resulted in higher larvae weight and a better feed conversion ratio; however, reaching 100% by-product inclusion values led to similar results between both diets. In conclusion, these treatments improve the potential of low-nutritional-value vegetable by-products as part of a T. molitor diet, opening the possibility of new methodologies for the use of recalcitrant vegetable by-products for insect rearing.
Olfactory Response of Sitophilus zeamais Adults to Odours of Semolina Pasta and Semolina Pasta Enriched with Different Amounts of Acheta domesticus Powder
Authors: Trematerra Pasquale , Colacci Marco , Messia Maria Cristina , Trivisonno Maria Carmela , Reale Anna , Boscaino Floriana , Germinara Giacinto Salvatore
Published: August 2024

The behavioural response of adult maize weevil, Sitophilus zeamais, to different types of semolina pasta enriched or not enriched with increasing proportions (5%, 10%, and 15%) of house cricket (Acheta domesticus) powder was investigated in olfactometer arena bioassays by using trap devices. In the five-choice behavioural bioassays, the number of S. zeamais adults attracted to 100% durum wheat semolina pasta was significantly higher than those attracted to the other pasta types enriched with A. domesticus powder. In the two-choice behavioural bioassays, the Response Index for each pasta type was positive and significant. However, although not significant, there was a progressive reduction in the Response Index as the cricket powder content increased. In similar experiments, there were no significant differences between cricket powder alone and the control in the number of attracted S. zeamais, indicating a neutral effect towards insects. These observations suggest that the lower attractiveness of pasta enriched with house cricket powder is mainly due to the masking of host food odours. Solid-phase microextraction coupled to gas chromatography–mass spectroscopy identified a total of 18 compounds in the head-space samples of the different types of pasta, highlighting differences in volatile composition. Some volatile compounds were only present in the pasta produced with cricket powder. In particular, 1-octen-3-ol and phenol were present in the samples containing 5%, 10%, or 15% cricket powder; pentanal, benzaldehyde, and dimethyl disulphide were present in samples containing 10% or 15% cricket powder; and 2,5-dimethyl-pyrazine was present in the sample containing 15% cricket powder. Further investigation with individual compounds and mixtures is needed to define the chemical basis of the differences in the insect olfactory preference observed in this study.
Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications
Authors: Liang Hsin-Yu , Lee Wei-Keung , Hsu Jui-Tsen , Shih Jie-Yu , Ma Tien-Li , Vo Thi Thuy Tien , Lee Chiang-Wen , Cheng Ming-Te , Lee I-Ta
Published: August 2024

Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including surface treatments, pore architecture adjustments, and the incorporation of biomaterials like hydroxyapatite (HA). These modifications aim to improve scaffold conformation, cellular behavior, and mechanical performance, with particular emphasis on the role of mesenchymal stem cells (MSCs) in bone regeneration. The review also explores the potential of integrating nanomaterials and graphene oxide (GO) to further enhance the mechanical and biological properties of PCL scaffolds. Future directions involve optimizing scaffold structures and compositions for improved bone tissue regeneration outcomes.
Effect of Photoaging on the Structure, Optical Properties and Roughness of One-Shade Composite Restoratives
Authors: Petropoulou Aikaterini , Dimitriadi Maria , Zinelis Spiros , Antoniadou Maria , Eliades George
Published: August 2024

The aim of the study was to evaluate changes in the degree of C=C conversion (DC%), chemical structure, optical properties and roughness of one-shade composites before/after photoaging. Τhe one-shade materials tested were Charisma Topaz One (CHT), Clearfil Majesty ES-2 Universal (MES), Essentia Universal (ESU) and Omnichroma (OMN), with G-aenial Anterior (CNA) serving as control. Specimens (2 mm thickness) were prepared and tested for DC% and chemical structure (ATR–FTIR spectroscopy), optical properties (L*a*b*–ΔΕ, translucency parameter–TP, opalescence parameter–OP, contrast ratio–CR and total transmittance–TT by UV–Vis spectroscopy) and roughness (Sa, Sz, Sdr, Sds and Sc by optical profilometry) before and after photoaging (Xe-arc weatherometer). Significant differences were found in DC% between top–bottom surfaces (ESU, OMN before; ESU, CNA after). Photoaging improved DC%, reduced ester peaks implying photodegradation, reduced L* (CHT, OMN, CNA), a* (CHT, CNA), b* (OMN, CNA), TP (all, except for MES), OP (only MES), CR (only MES, but an increase in CNA) and TT (CHT, OMN). OMN, CNA and MES demonstrated ΔΕ > 3.3. Photoaging significantly increased all roughness parameters in all materials, except for MES (Sz, Sdr, Sc) and OMN (Sdr). Although listed in the same group, significant differences were found in one-shade composites before and after photoaging. Several products were strongly affected by photoaging, demonstrating evidence of photodegradation, an increased roughness and color changes exceeding the clinically acceptable levels.
Novel Challenges and Therapeutic Options for Pulmonary Embolism and Deep Vein Thrombosis
Authors: Cavallino Chiara , Franzino Marco , Abdirashid Mohamed , Maltese Ludovica , Bacci Elodi , Rametta Francesco , Ugo Fabrizio
Published: August 2024

Acute pulmonary embolism (PE), often resulting from deep vein thrombosis (DVT), is the third most frequent cause of cardiovascular death and is associated with increasing incidence, causing considerable morbidity and mortality. This review aims to evaluate the efficacy, safety, and outcomes of treatment options in the management of acute PE and DVT, encompassing both established and emerging technologies, such as catheter-directed thrombolysis, aspiration thrombectomy, and other endovascular techniques. A comprehensive literature review was conducted, assessing clinical studies, trials, and case reports that detail the use of percutaneous interventions for PE and DVT and analyzing the advantages and disadvantages of each percutaneous system. Several percutaneous treatments have shown promising results, especially in cases where rapid thrombus resolution is critical, such as in high- and intermediate–high-risk patients. The incidence of major complications, such as bleeding, remains a consideration, though it is generally manageable with proper patient selection and technique. It is fundamentally important to tailor the specific treatment strategy to the clinical and anatomical characteristics of each patient. Percutaneous treatments for acute PE and DVT represent valuable options in the therapeutic arsenal, offering enhanced outcomes in appropriately selected patients. Ongoing advancements in technology and technique, along with comprehensive clinical trials, are essential to further define the role and optimize the use of these interventions.
DiADEM—Dance against Dementia—Effect of a Six-Month Dance Intervention on Physical Fitness in Older Adults with Mild Cognitive Impairment: A Randomized, Controlled Trial
Authors: Thiel Ulrich , Stiebler Marvin , Labott Berit K. , Bappert Johanna , Langhans Corinna , Halfpaap Nicole , Grässler Bernhard , Herold Fabian , Schreiber Stefanie , Braun-Dullaeus Rüdiger , Müller Patrick , Müller Notger , Hökelmann Anita
Published: August 2024

Background: Preserving health and physical fitness is critical to ensure independent living across the lifespan. Lower levels of physical fitness are associated with age-related cognitive decline and a higher prevalence of mild cognitive impairment (MCI). Thus, this study investigates the influence of a six-month dance intervention on selected measures of physical fitness in older adults with MCI. Methods: In this randomized controlled trial, 55 patients with MCI were randomized into a sportive dance training (IG; n = 26; age: 70.7 ± 5.6 years; 62% female) or an inactive control group (CG; n = 24; age: 69.1 ± 6.8 years; 46% female). The dance group received two 90 min dance training sessions per week over a duration of six-months, which focused on learning dance movement patterns. During the training sessions, heart rate was measured to control exercise intensity. Physical fitness was assessed using cardiopulmonary exercise testing (CPET), lower limb functional fitness via sit-to-stand test, handgrip strength, and heart rate variability (HRV). Results: We observed that the dance intervention preserved the cardiorespiratory fitness as measured by maximal oxygen uptake (VO2max) during CPET, which decreased in the CG. Furthermore, participants in the IG demonstrated increases in leg and handgrip strength, although these were not statistically significant. HRV displayed a non-significant decrease following the intervention. Conclusions: The results of this randomized controlled trial suggest that sportive dance training can preserve elements of physical fitness (i.e., cardiorespiratory fitness) in older adults with MCI. Although improvements in the other parameters (i.e., leg and handgrip strength) were statistically non-significant, likely due to the small sample size, stabilizing muscular fitness and preventing age-related decline in older adults with MCI is important for maintaining functional independence. For future studies, we recommend a longer training duration paired with precise control of regular physical activity levels, an important confounding factor.
Management of Severe Bilateral Symptomatic Internal Carotid Artery Stenosis: Case Report and Literature Review
Authors: Robu Mircea , Radulescu Bogdan , Margarint Irina-Maria , Dragan Anca , Stiru Ovidiu , Gorecki Gabriel-Petre , Voica Cristian , Iliescu Vlad Anton , Moldovan Horatiu
Published: August 2024

Multiple strategies for tandem severe carotid artery stenosis are reported: bilateral carotid artery endarterectomy (CEA), bilateral carotid artery stenting (CAS), and hybrid procedures (CEA and CAS). The management is controversial, considering the reported high risk of periprocedural stroke, hemodynamic distress, and cerebral hyperperfusion syndrome. We present the case of a 64-year-old patient with severe symptomatic bilateral internal carotid artery stenosis (95% stenosis on the left internal carotid artery with recent ipsilateral watershed anterior cerebral artery–medial cerebral artery (ACA-MCA) and medial cerebral artery–posterior cerebral artery (MCA-PCA) ischemic strokes and 90% stenosis on the right internal carotid artery with chronic ipsilateral frontal ischemic stroke) managed successfully with staged CEA within a 3-day interval. The patient had a history of coronary angioplasty and stenting. Strategies for brain protection included shunt placement after the evaluation of carotid stump pressure, internal carotid backflow, and near-infrared spectroscopy. A collagen and silver-coated polyester patch was used to complete the endarterectomy using a 6.0 polypropylene continuous suture in both instances. Management also included neurological consults after extubation, dual antiplatelet therapy, head CT between the two surgeries, myocardial ischemia monitoring, and general anesthesia. Staged CEA with a small time interval between surgeries can be an option to treat tandem symptomatic carotid artery stenosis in highly selected patients. The decision should be tailored according to the patient’s characteristics and should also be made by a cardiology specialist, a neurology specialist, and an anesthesia and intensive care physician.
Psychodynamic Insights into Treatment-Resistant Pharmacotherapy: A Case Study Exploring Patient–Physician Dynamics and Adherence to Evidence-Based Practices
Authors: Baur Alexander , Kryzanowski Leslie
Published: August 2024

Background: Pharmacological resistance in severe recurrent mood and anxiety disorders remains a significant challenge in modern biological psychiatry. This case report investigates the intricate decision-making process employed by physicians when managing patients resistant to conventional pharmacotherapy. Methods: Informed consent was obtained from the patient. Following this, the case report was developed using the CARE checklist (2013) to ensure a comprehensive and systematic documentation of the treatment process and outcomes. Results: The patient’s treatment history highlights the complex nature of pharmacological resistance and the impact of minor medication adjustments versus established clinical practices. A crucial aspect of this case was the patient–physician relationship, particularly addressing the patient’s past grievances towards physicians, which played a significant role in the treatment process. Despite efforts to improve the physician’s confidence and approach, challenges such as lack of continuity and a fragile therapeutic relationship contributed to treatment failure. Conclusions: This case underscores the importance of psychodynamic models in overcoming pharmacologic challenges. A deeper understanding of the patient–physician dynamics and addressing underlying emotional factors can enhance treatment efficacy and patient outcomes, providing valuable lessons for managing complex cases of treatment resistance.
Machine Learning Predictions and Identifying Key Predictors for Safer Intubation: A Study on Video Laryngoscopy Views
Authors: Kim Jong-Ho , Han Sung-Woo , Hwang Sung-Mi , Lee Jae-Jun , Kwon Young-Suk
Published: August 2024

This study develops a predictive model for video laryngoscopic views using advanced machine learning techniques, aiming to enhance airway management’s efficiency and safety. A total of 212 participants were involved, with 169 in the training set and 43 in the test set. We assessed outcomes using the percentage of glottic opening (POGO) score and considered factors like the modified Mallampati classification, thyromental height and distance, sternomental distance, mouth opening distance, and neck circumference. A range of machine learning algorithms was employed for data analysis, including Random Forest, Light Gradient Boosting Machine, K-Nearest Neighbors, Support Vector Regression, Ridge Regression, and Lasso Regression. The models’ performance was evaluated on the test set, with Root Mean Squared Error values ranging from 20.4 to 21.9. SHapley Additive exPlanations value analysis revealed that age is a consistent and significant predictor of POGO score across all models, highlighting its critical role in the predictive accuracy of these techniques.
Mangrove Ecotourism along the Coasts of the Gulf Cooperation Council Countries: A Systematic Review
Authors: Moussa Lara G. , Mohan Midhun , Burmeister Nicola , King Shalini A. L. , Burt John A. , Rog Stefanie M. , Watt Michael S. , Udagedara Susantha , Sujud Lara , Montenegro Jorge F. , Heng Joe Eu , Carvalho Susana Almeida , Ali Tarig , Veettil Bijeesh Kozhikkodan , Arachchige Pavithra S. Pitumpe , Albanai Jasem A. , Sidik Frida , Shaban Amin , Peñaranda Martha Lucia Palacios , El Beyrouthy Naji , Novo Ana , Abdullah Meshal M. , Abulibdeh Ammar , Al-Awadhi Talal , Cardil Adrián , Ewane Ewane Basil
Published: August 2024

Mangrove ecotourism is gaining immense popularity in the Gulf Cooperation Council (GCC) countries as a neoliberal conservation tool, and it has contributed significantly to the growth of the tourism sector in the region over the past two decades. However, there is no comprehensive review on the full extent of mangrove ecotourism activities and the contribution to mangrove conservation/restoration and economic growth in the region. A systematic literature review approach was used to examine the evolution of mangrove ecotourism in the GCC countries from 2010 to 2023. A total of 55 articles were retrieved from the Google and Google Scholar search engines, and the Scopus and Web of Science databases were incorporated. We synthesized the results and provided perspectives on the following: (1) the geographical and temporal distribution of studies in relation to mangrove extent, (2) key sites, attractions, and values for mangrove ecotourism activities, (3) the positive and negative impacts of mangrove ecotourism, and (4) existing mangrove conservation and restoration initiatives for the growth of mangrove ecotourism in the GCC countries. The findings underscore the significance of mangrove ecotourism in supporting economic development, protecting coastal ecosystems, and sustaining local livelihoods in the GCC countries. However, this study highlights the crucial need for sustainable coastal environmental management through integrated land use planning and zoning to address the negative impacts of anthropogenic pressures on mangrove ecosystems and ecotourism attractions. The use of remote sensing tools is invaluable in the monitoring of mangrove ecosystems and associated ecotourism impacts for informing evidence-based conservation and restoration management approaches. Thus, harnessing mangrove ecotourism opportunities can help the GCC countries with balancing economic growth, coastal environmental sustainability, and community well-being.
Spatial Distribution and Location Determinants of High-Tech Firms in Shenzhen, a Chinese National Innovative City
Authors: Cui Lu , Shen Jing , Mai Zhuolin , Lin Chenghui , Wang Shaogu
Published: August 2024

The development of high-tech firms is a vital driver for the economic growth of a city but their distribution and location determinants at the intra-urban level are still unclear. We aim to deepen the understanding of location determinants of high-tech firms, so we construct an analytical framework and use GeoDetector to investigate high-tech firms in Shenzhen based on firms and POI open data in 2023. We find that high-tech firms are distributed in a spatial pattern of ‘one core and six clusters’ with high density in the western area despite industrial heterogeneity. Agglomeration economies and amenity-based factors play a significant role in the distribution of high-tech firms. Institutional factors and classical locational factors have more significant effects on the location of high-tech service and manufacturing firms, respectively. This study contributes to the literature on study spatial units, the influence of amenities, and industrial specificities. These findings highlight public policies on industrial park planning, transportation systems, and public services.
Green and Low Carbon Development Performance in Farmland Use Regulation: A Case Study of Liyang City, China
Authors: Lin Yaoben , Wang Xuewen , Li Guangyu , Shen Wei
Published: August 2024

Farmland use regulation strictly regulates the conversion of agricultural land for other agricultural purposes and the construction of agricultural facilities, thereby optimizing the land use pattern in rural areas. However, different measures and intensities of farmland use regulation can affect the overall performance of green and low-carbon development in rural areas. This study utilizes system dynamics modeling and simulation to conduct a case study based on current land use data from 10 towns in Liyang City, China. The empirical results indicate the following: (1) Based on comprehensive measurements of green and low carbon development performance, Liyang City exhibits a pattern of higher indices in the south and lower indices in the north. Towns such as Tianmu Lake, Daibu, and Shezhu show relatively high average comprehensive indices of 0.31, 0.30, and 0.28, significantly higher than other towns. (2) Simulation of farmland use regulation’s impact on green and low carbon development performance reveals that Scenario One, involving additional construction land occupying farmland, achieves a comprehensive index of only 0.23, significantly lower than the other scenarios. (3) Based on calculations and field surveys, Liyang City’s villages are categorized into four types, with the largest number being industry-integrated villages (94 villages). Accordingly, policies for farmland use regulation are designed for different village types. Therefore, future farmland use regulation should be tailored with differentiated institutional designs according to the development needs of different villages. This study’s findings provide insights into green and low-carbon development in rural areas.
Plant-Based Oils for Sustainable Lubrication Solutions—Review
Authors: Berman Diana
Published: August 2024

Traditional lubricants, often containing harmful chemicals and synthetic or fossil-derived oils, pose environmental risks by damaging ecosystems and threatening human health and wildlife. There is a growing demand for environmentally sustainable and cost-effective bio-based lubricants derived from renewable raw materials. These bio-based oils often possess natural lubricating properties, making them an attractive alternative to traditional synthetic lubricants. In addition to providing effective lubrication, they offer good biodegradability and minimal toxicity, which are essential for reducing environmental impact. However, the primary challenge lies in optimizing their performance to match or surpass that of conventional lubricants while ensuring they remain cost-effective and widely available. This paper reviews the general requirements for lubricants and explores how plant-based oils can be utilized to meet the diverse lubrication needs across various industries. Further, it highlights different approaches that can be used for further improvements in the area of plant-based lubrication through bio-inspired means, such as the use of estolides, wax esters, or erucic acid, as well as through additions of nanomaterials, such as nanoparticles, nanoclays, or two-dimensional films.
On the Aptness of Material Constitutive Models for Simulating Nano-Scratching Processes
Authors: Shen Hao , Kulasegaram Sivakumar , Brousseau Emmanuel
Published: August 2024

The simulation of nano-scratching on metallic substrates using smooth particle hydrodynamics (SPH) has been attempted by researchers in recent years. From a review of the existing SPH simulations of nano-scratching processes, it was found that mainly two different material constitutive models (i.e., the Johnson–Cook model and the elasto-plastic model) were employed to describe the material flow. In the majority of these investigations, the Johnson–Cook model was employed to characterise the stress flow of the material subjected to scratching. A natural question remains as to which material constitutive model is preferable for the SPH modelling of nano-scratching when quantitatively predicting the process outcomes. In this paper, a quantitative comparison of material responses during the nano-scratching of copper is reported when the process is simulated using SPH with two different constitutive material models, namely the Johnson–Cook and the elasto-plastic models. In particular, the simulated cutting and normal forces as well as the machined topography using both approaches are compared with the experimental work reported in the literature. The SPH-based simulation results in this paper are investigated based on the following three aspects: (a) cutting and normal forces with different material models and depths of the cut, (b) the effect of the cutting speed on forces and its dependence on adopted material models, and (c) the effect of adopted material models on the surface topography of machined nano-grooves. The SPH simulation results showed that using the Johnson–Cook material model, cutting and normal forces were closer to the experimental data compared to the results obtained with the elasto-plastic model. The results also showed that the cross-sectional profile of simulated nano-grooves using the Johnson–Cook model was closer to the experimental results. Overall, this paper shows that the selection of the Johnson–Cook model is preferable for the SPH modelling of the nano-scratching process.
Glutamic-Alanine Rich Glycoprotein from Undaria pinnatifida: A Promising Natural Anti-Inflammatory Agent
Authors: Rahman Md Saifur , Alam Md Badrul , Naznin Marufa , Madina Mst Hur , Rafiquzzaman S. M.
Published: August 2024

This study aimed to assess the anti-inflammatory properties of a bioactive glutamic-alanine rich glycoprotein (GP) derived from Undaria pinnatifida on both LPS-stimulated RAW264.7 cells, peritoneal macrophages, and mouse models of carrageenan- and xylene-induced inflammation, investigating the underlying molecular mechanisms. In both in-vitro and in-vivo settings, GP was found to reduce the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) while also inhibiting the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in response to lipopolysaccharide (LPS) stimulation. GP treatment significantly impeded the nuclear translocation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway by blocking the phosphorylation of IKKα and IκBα, leading to a reduction in proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Additionally, GP effectively inhibited the activation of mitogen-activated protein kinases (MAPKs), with specific inhibitors of p38 and extra-cellular signal regulated kinase (ERK) enhancing GP’s anti-inflammatory efficacy. Notably, GP administration at 10 mg/kg/day (p.o.) markedly reduced carrageenan-induced paw inflammation and xylene-induced ear edema by preventing the infiltration of inflammatory cells into targeted tissues. GP treatment also downregulated key inflammatory markers, including iNOS, COX-2, IκBα, and NF-κB, by suppressing the phosphorylation of p38 and ERK, thereby improving the inflammatory index in both carrageenan- and xylene-induced mouse models. These findings suggest that marine resources, particularly seaweeds like U. pinnatifida, could serve as valuable sources of natural anti-inflammatory proteins for the effective treatment of inflammation and related conditions.
Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review
Authors: Krsek Antea , Jagodic Ana , Baticic Lara
Published: August 2024

Nanomedicine is a newer, promising approach to promote neuroprotection, neuroregeneration, and modulation of the blood–brain barrier. This review includes the integration of various nanomaterials in neurological disorders. In addition, gelatin-based hydrogels, which have huge potential due to biocompatibility, maintenance of porosity, and enhanced neural process outgrowth, are reviewed. Chemical modification of these hydrogels, especially with guanidine moieties, has shown improved neuron viability and underscores tailored biomaterial design in neural applications. This review further discusses strategies to modulate the blood–brain barrier—a factor critically associated with the effective delivery of drugs to the central nervous system. These advances bring supportive solutions to the solving of neurological conditions and innovative therapies for their treatment. Nanomedicine, as applied to neuroscience, presents a significant leap forward in new therapeutic strategies that might help raise the treatment and management of neurological disorders to much better levels. Our aim was to summarize the current state-of-knowledge in this field.
Right Ventricular Myxoma with a Papillary Muscular Origin
Authors: Osipenko Kira , Angleitner Philipp , Heinrich Nikolaus , Zimpfer Daniel , Andreas Martin
Published: August 2024

Cardiac myxomas in the right ventricle are a very rare condition. In this case report, we describe an exceptionally uncommon case involving a right ventricular cardiac myxoma, originating from a papillary muscle, extending to both the tricuspid valve and the right atrium. The valve was able to be repaired via artificial chorda implantation.
Simulating the Permeation of Toxic Chemicals through Barrier Materials
Authors: Bicket Alex , Lau Vivian , Thibault Jules
Published: August 2024

Chemical warfare agents that are liquids with low vapor pressure pose a contact hazard to anyone who encounters them. Personal protective equipment (PPE) is utilized to ensure safe interaction with these agents. A commonly used method to characterize the permeability of PPE towards chemical weapons is to apply droplets of the liquid agent to the surface of the material and measure for chemical breakthrough. However, this method could produce errors in the estimated values of the transport properties. In this paper, we solved numerically the three-dimensional cylindrical Fick’s second law of diffusion for a liquid permeating through a non-porous rubbery membrane to determine the time the permeating species will emerge on the other side of the polymer membrane. Simulations of different amounts of surface area coverage and the geometries of permeate on the membrane surface indicated that incomplete surface area coverage affects the estimation of the transport properties, making the experimentally determined transport properties unsuitable for predictive use. We simulated different permeation values to determine the factors that most influenced the estimation error and if the error was consistent over different permeate–membrane combinations. Finally, a method to correct the experimentally determined permeability is suggested.
Evolution Characteristics of Aluminum Thermal Weld Irregularity and Damage in Heavy-Haul Railway under Different Service Conditions
Authors: Liu Guangpeng , Zhang Nan , Huang Weiming , Shi Guoliang , Xiao Hong , Huang Linchong , Liu Xin
Published: August 2024

Aluminum thermal welding joints are widely used in the maintenance welding of heavy-haul railways due to their easy handling and high efficiency. However, due to their inherent welding characteristics, welding results in certain differences in the material’s physical properties at the welding zone compared to adjacent base materials, leading to the occurrence of short-wave irregularity under long-term wheel–rail interactive forces. In order to explore the evolution characteristics of weld irregularity, dynamic characteristics, and plastic deformation under long-term wheel–rail impact, a detailed tracking test was conducted on a normal aluminum weld, and the process from being put on the track to being damaged and replaced was evaluated. At the same time, a rigid–flexible coupling model was established for subsequent analysis, and plastic damage was analyzed using the finite element model. The results show that the service life of the weld can be divided into three different stages: the initial stage, the intermediate stage, and the damage stage. In the damage stage, a temporary separation occurred between the wheel and rail, leading to a sudden change in the wheel–rail interaction. The weight of 250 MT at the weld reached the repairment control limit. The concentration effect of equivalent plastic deformation was most serious at 2~5 mm below the rail head.
Machine-Learning-Assisted Composition Design for High-Yield-Strength TWIP Steel
Authors: Zhou Xiaozhou , Xu Jiangjie , Meng Li , Wang Wenshan , Zhang Ning , Jiang Lei
Published: August 2024

Twinning-induced plasticity (TWIP) steel is an ideal material for impact-resistant structures and energy absorption because of its high product of strength and elongation. However, compared with other advanced high-strength steels, the relatively low yield strength of TWIP steel is one of the important shortfalls that significantly limits its engineering applications. To enhance the comprehensive properties of TWIP steel, a machine learning design strategy that integrated comparative modelling, SHAP analysis, and multi-objective optimization were adopted in this study. Initially, various machine learning algorithms were compared for their predictive accuracy based on normalized data (273 entries) regarding the microstructure and properties of TWIP steel. Then, performance prediction models for yield strength, tensile strength, and elongation were established. SHAP analysis was subsequently employed to assess the significance and explicit laws of composition and microstructures in these three target properties, identifying key elements that enhance the overall performance. Furthermore, two new TWIP steels with high yield strengths and high products of strength and elongation were developed via multi-objective optimization. Under conventional hot forging + hot rolling + cold rolling + annealing processes, the two designed TWIP steels had yield strengths of 585 MPa and 560 MPa, tensile strengths of 1055 MPa and 1101 MPa, elongations of 55% and 58.5%, and products of strength and elongation of 58.0 GPa% and 66.4 GPa%, respectively. The yield strengths of the designed TWIP steels significantly improved while maintaining a reasonable product of strength and elongation. This work provides important references for the rational development of new TWIP steels.
On the Relationship between Thermomechanical Processing Parameters and Recrystallization Texture in AA1100 Aluminum Alloy
Authors: Yang Hsin-Lun , Hsiao Shih-Chieh , Chang Chih-I , Tseng Tien-Yu , Chen Po-Jen , Kuo Jui-Chao
Published: August 2024

In this study, 48 hot-rolling processing conditions were designed to investigate the influences of thermomechanical processing parameters on the recrystallization behavior and texture development. The hot-rolling experiments were conducted using the thermomechanical simulator Gleeble 3800 at temperatures of 275, 300, and 350 °C with strain rates of 5 and 90 s−1 up to 60 and 85% reduction. The microstructure and texture analysis were measured by using the EBSD technique on a large area. Experimental results show that the Cube component maintains a volume fraction between 10% and 20%, below the 40% recrystallization fraction, but the volume fraction of Cube significantly increases between 20% and 50% above the 40% recrystallization fraction. However, the fractions of Rotated Cube (RC) and Goss components remain below 10%.
Association of Initial Muscle Fitness with Weight Loss and Metabolically Healthy Status in Children and Adolescents with Obesity: A Retrospective Study
Authors: Shang Wenya , Kong Jiaqi , Zhang Mengxue , Chen Tao , Zhao Linlin , Wang Kun , Yang Qin
Published: August 2024

This retrospective study aimed to investigate the association of initial muscular fitness (MF) with weight loss and metabolic health status in 282 children and adolescents with obesity during 3 to 4 weeks of diet- and exercise-based interventions. Metabolically healthy obesity (MHO) definitions established in 2023 and MF standards based on the 2021 Chinese children’s grip strength grading were applied. The proportion of metabolically unhealthy obesity (MUO) was higher in the high MF group than in their low MF counterparts at baseline. After the intervention, neither group transitioned from MUO to MHO due to the high frequency of low HDL-C. High MF females showed a higher percentage of high systolic blood pressure (SBP) than low MF females before and after intervention. High MF males exhibited greater improvements in waist circumference, hip circumference, waist-hip ratio, triglycerides, total cholesterol, and LDL-C than low MF males. The benefits of weight loss and blood lipids obtained by males are more evident than those obtained by females under the same MF level. Thus, attention should be paid to females during weight loss regardless of MF levels. Precision therapy should prioritize the management of blood pressure and avoid excessive reduction in HDL-C levels to sustain metabolic health.
Acoustic Transmission Measurements for Extracting the Mechanical Properties of Complex 3D MEMS Transducers
Authors: Becker Dennis , Littwin Moritz , Bittner Achim , Dehé Alfons
Published: August 2024

Recent publications on acoustic MEMS transducers present a new three-dimensional folded diaphragm that utilizes buried in-plane vibrating structures to increase the active area from a small chip volume. Characterization of the mechanical properties plays a key role in the development of new MEMS transducers, whereby established measurement methods are usually tailored to structures close to the sample surface. In order to access the lateral vibrations, extensive and destructive sample preparation is required. This work presents a new passive measurement technique that combines acoustic transmission measurements and lumped-element modelling. For diaphragms of different lengths, compliances between 0.08 × 10−15 and 1.04 × 10−15 m3/Pa are determined without using destructive or complex preparations. In particular, for lengths above 1000 µm, the results differ from numerical simulations by only 4% or less.
The Microstructure and Properties of Ni60/60% WC Wear-Resistant Coatings Prepared by Laser-Directed Energy Deposition
Authors: Yang Husen , Li Wen , Liu Yichun , Li Fengxian , Yi Jianhong , Eckert Jürgen
Published: August 2024

Ni60/60% WC composite coatings with a good surface roughness and high mechanical properties were successfully prepared on 316L stainless steel substrate by laser-directed energy deposition (LDED) technology. The effects of laser power on the microstructural evolution and mechanical properties of the Ni60/60% WC composite coating were investigated. The relationships between the chemical composition, the microstructure, the hardness, and the friction wear resistance of the composite coatings were characterized and investigated. The results show that the laser power had a significant effect on the energy input, which determined the melting extent of the Ni60 phases around the WC particles and the bonding strength between the reinforcements and the matrix, as well as the bonding strength between the substrate and the coatings. With an increase in the laser power from 800 W to 1400 W, the average hardness of the coating surface increased due to the increased densification of the deposited coatings and then decreased due to grain coarsening under a high energy input. The average coefficient of friction of the coatings decreased gradually to 0.383 at 1000 W, showing a minimum wear of 0.00013 mm2 at 1200 W. The main wear mechanisms on the coated surfaces were adhesive wear and abrasive wear. Moreover, the coatings deposited at 1200 W exhibited better forming quality and wear resistance. This work suggests that the processing parameters during LDED can be optimized to prepare Ni60/60% WC wear-resistant coatings with excellent mechanical properties.
Coal and Coal By-Products as Unconventional Lithium Sources: A Review of Occurrence Modes and Hydrometallurgical Strategies for Metal Recovery
Authors: Rudnik Ewa
Published: August 2024

Lithium, a critical material for the global development of green energy sources, is anomalously enriched in some coal deposits and coal by-products to levels that may be considered economically viable. Recovering lithium from coal, particularly from coal gangue or coal ashes, offers a promising alternative for extracting this element. This process could potentially lead to economic gains and positive environmental impacts by more efficiently utilizing coal-based waste materials. This review focuses on lithium concentrations in coal and coal by-products, modes of lithium occurrence, methods used to identify lithium-enriched phases, and currently available hydrometallurgical recovery methods, correlated with pretreatment procedures that enable lithium release from inert aluminosilicate minerals. Leaching of raw coal appears inefficient, whereas coal gangue and fly ash are more feasible due to their simpler composition and higher lithium contents. Lithium extraction can achieve recovery rates of over 90%, but low lithium concentrations and high impurity levels in the leachates require advanced selective separation techniques. Bottom ash has not yet been evaluated for lithium recovery, despite its higher lithium content compared to feed coal.
Genesis of the Mengshan Granitoid Complex in an Early Mesozoic Intracontinental Subduction Tectonic Setting in South China: Evidence from Zircon U-Pb-Hf Isotopes and Geochemical Composition
Authors: Wei Jin , Ouyang Yongpeng , Zou Jing , Zeng Runling , Zhang Xinming , Zhang Tao , Sui Shenao , Zhang Da , He Xiaolong , Zhang Yaoyao
Published: August 2024

The Mengshan granitoid complex is located in the central part of Jiangnan Orogen and belongs to the western part of Jiangxi Province, where several phases of granitic magmatism record the crustal evolution of the late-Indosinian. However, its petrogenesis remains uncertain, largely due to controversies over its origin, evolutionary process and tectonic setting during intrusion. In this study, the lithological features and contact relationships observed in the systematic field geological investigations indicate that the late magmatic phases of the Mengshan granitoid complex are mainly composed of medium–fine-grained biotite monzogranite and fine-grained monzogranite, both of which developed primary fine-grained muscovite. Petrological, petrographic, geochemical and zircon U-Pb-Hf isotopic studies were further carried out on these rocks. Zircon U-Pb isotopic analyses suggest that the medium–fine-grained biotite monzogranite mainly formed at 220.7 ± 1.0 Ma to 218.0 ± 0.8 Ma, and that the fine-grained monzogranite formed at 211.5 ± 2.9 Ma to 212.9 ± 1.0 Ma. Whole-rock geochemical analysis results suggest that these rocks are rich in Cs, Rb, and U, and deficient in Ba, Sr, and Ti, and that they have properties characteristic of rocks with high silica, low P content and high K calc-alkali. Mineralogical and geochemical analysis results suggest that they are S-type granites. The εHf(t) values of the early-stage medium–fine-grained biotite monzogranite and late-stage fine-grained monzogranite range from –4.7 to 0.3 and from –3.2 to 0.7, respectively. Geochemical and isotopic data suggest that these granitoids were derived from the partial melting of Proterozoic continent basement rocks, and that minor mantle materials were involved during their generation. The presence of the early Mesozoic Mengshan granitoid complex reflects a reduplicated far-field converge effect of the collision of the North China and South China blocks and the subduction of the Palaeo-Pacific plate into the South China block. The thickening of the Earth’s crust facilitated crustal delamination, underplating of mantle-derived magma, and crustal heating, triggering intense partial melting of the lithosphere and magma enrichment.
Novel Indigenous Strains and Communities with Copper Bioleaching Potential from the Amolanas Mine, Chile
Authors: Casas-Vargas Julián C. , Martínez-Bussenius Cristóbal , Videla Álvaro , Vera Mario
Published: August 2024

Bioleaching, a process catalyzed by acidophilic microorganisms, offers a sustainable approach to metal extraction from sulfide minerals. Chalcopyrite, the world’s most abundant copper sulfide, presents challenges due to surface passivation limiting its bioleaching efficiency. Also, indigenous species and microbial communities may present high copper extraction rates and offer new possibilities for application in bioleaching processes. This study examines the bioleaching potential of microbial isolates and communities obtained from Amolanas Mine in Chile. Samples were collected, cultivated, and identified by Sanger sequencing. The bioleaching potential and biofilm formation of isolates and enrichments were evaluated on pyrite and chalcopyrite. The results show the isolation of nine Leptospirillum and two Acidithiobacillus strains. The bioleaching experiments demonstrated good copper bioleaching potentials of the Leptospirillum I2CS27 strain and EICA consortium (composed mainly of Leptospirillum ferriphilum, Acidiphilium sp., and Sulfobacillus thermosulfidooxidans), with 11% and 25% copper recovery rates, respectively. Microbial attachment to the surface mineral was not mandatory for increasing the bioleaching rates. Our findings underscore the importance of indigenous microbial communities in enhancing copper bioleaching efficiency.