bluuebunny/crossref_metadata_2025 huggingface dataset:
Shifting dynamics of Dengue in Ningbo City, China: Impacts of ENSO and Interventions before, during and after the COVID-19 pandemic
Authors: Chu Yanru , Zhao Yunkang , Abudunaibi Buasiyamu , Wang Yao , Zhang Yanwu , Lei Song , Zhu Zhixin , Tong Feng , Chen Tianmu , Chen Yi
Published: December 2024

Ningbo City, historically non-endemic for dengue, indigenous cases emerged between 2015 and 2020. The persistence of the El Niño phenomenon has further elevated the risk, which is compounded by the influx of visitors for the forthcoming 19th Asian Games, potentially heightening the likelihood of indigenous transmission. In response to these challenges, a series of interventions are implemented during and after the COVID-19 pandemic. We investigated the changes in dengue dynamics and variations in meteorological factors influenced by ENSO between 2017 and 2023. We observed that there is no recurrence of indigenous transmission in the post-COVID-19 pandemic period. Individuals aged 30–39 and older, as well as unemployed, retired individuals, and residents of Haishu District and Yinzhou District, exhibit a higher risk of dengue infection. A consistent decrease in onset to diagnosis interval is observed over the study period. Trends indicated an increase in Aedes mosquito density in Yinzhou, Haishu, and Fenghua districts, contrary to a significant decline in all other districts. Aedes mosquito population density is associated with temperatures, precipitation, and other meteorological factors. Despite the rising temperatures, precipitation, and population density growth, the previously escalating Aedes mosquito population density has been effectively controlled during the post-COVID-19 period. The dynamic model demonstrates that without interventions during the post-COVID-19 era, there is a risk of the resurgence of indigenous cases. Our analysis demonstrates that the reemergence of indigenous dengue cases in Ningbo City before the COVID-19 pandemic is effectively controlled through continual enhancements in preventive and control measures during and after the COVID-19 pandemic. These findings indicate that despite the rising dengue risk and the recent global surge in dengue cases, effective dengue control can be attained through the consistent adaptation and optimization of interventions.
Development of a National Medical Leadership Competency Framework: Syrian Approach
Authors: Shaddoud Abla , Al-Munajed Mohamad Kusai , Dashash Mayssoon
Published: December 2024

Background and Objectives: As team-based practices and integrated care approaches become more prevalent, it is essential for physicians to be skilled practitioners capable of functioning efficiently and effectively within complex health systems. In addition to clinical expertise, they should also develop management and leadership competencies. This study aimed to identify the medical leadership competencies among healthcare professionals in the Syrian Arab Republic.
Methods: The study involved 86 participants. The Self-assessment tool NHS Leadership test was applied, comprising 40 questions. Data was collected through a Google Form which was distributed online. The results were analysed using statistical software SPSS version 24.
Results: Findings showed that the perceptions of resident doctors in Syrian government hospitals regarding the medical leadership competencies were moderate overall, with some items ranked low. The responses revealed that “Demonstrating personal qualities” was the most consistently recognized leadership competencies, with a mean score of (3.42). There were no statistically significant differences at the 0.05 level in medical leadership competencies based on residency year and specialization, although significant differences were observed favoring male participants.
Conclusions: There is a critical need to enhance leadership effectiveness among healthcare professionals in the Syrian Arab Republic, especially in the areas of Setting Direction and Managing services, which received the lowest rankings. This improvement should begin at the undergraduate level through targeted courses during academic semesters, followed by continuous training and exposure to systematic rehabilitation programs during residency.
Knowledge, attitudes, and practices of cervical cancer and cervical cancer screening in a rural setting of a low-income country: A cross-sectional study in the Busoga Region of Uganda
Authors: Einarson Troels Alnor , Musana Emmanuel , Balonde Joseph , Lorentzen Katinka Bolette , Kallestrup Rasmus , Juncker Margrethe , Damoi Joseph Okello , Nakami Sylvia , Kallestrup Per
Published: December 2024

Background: Cervical cancer (CC) is a major non-communicable health issue in low- and lower-middle income countries, such as Uganda. Effective cervical cancer screening (CCS) and vaccination can effectively eliminate the disease as a public health issue, but these initiatives are lacking behind as CC is the most common cancer in Uganda. Future information-, screening-, and vaccinationcampaigns should be founded on a scientific depiction of the women’s understanding of the issue and solutions, to ensure a sustainable public health benefit.
Methods: We performed a cross-sectional study in 5 districts of the Busoga Region of Uganda to assess rural women’s knowledge, attitudes, and practices of CC and CCS. Women ≥18 years old were included through random sampling. Data was collected using a digital questionnaire administered by trained research assistants recruited from the study area. Results are presented with descriptive statistics and logistic regression for sociodemographic predictors of KAP scores via crude and adjusted models, at a p-value of .05.
Results: 585 participants were included. 57% had primary education and 83.9% were farmers. 92.1% had heard about cancer and 87.5% CC, while a minority knew of any symptoms (36.8%), risk factors (42.5%), and preventive measures (49%) of CC. Lay beliefs included poor hygiene and contraceptives as risk factors. Attitudes showed a good understanding of CC severity, preventability, and curability, and little indication of taboo. The respondent’s attitudes lacked clarity on vaccination and screening benefits as 35.6% did not know that HPV vaccination prevents CC and 24.1% did not know that screening could detect early CC. 9.1% had ever attended CCS with 12% in the 30 - 49-year-old target group. Predictors of KAP scores were identified and discussed from the perspective of similar studies.
Conclusions: This study identified CC knowledge gaps in symptom awareness, risk, and preventive factors. Most women held favourable attitudes towards the disease, but less favourable towards preventive measures. Low screening prevalence indicated a need to improve public health initiatives.
A rapid prediction model for trauma-induced coagulopathy in severe trauma: a retrospective study
Authors: Zhuang Xinsuo , Zhou Qian , Wang Yadong , Geng Xiaonan , Chen Naiyun , Yang Xiaofeng , Bai Xueli
Published: December 2024

Background
There is little data regarding the method for predicting trauma-induced coagulopathy (TIC) in patients with severe trauma to facilitate early intervention. This study aimed to establish a prediction model for the early diagnosis of TIC in trauma patients.
Methods
The patients included were divided into two groups based on the presence or absence of TIC. Fourteen potential variables were included in this study. These data were subjected to univariate analysis, followed by logistic multivariate regression analysis to identify independent risk factors affecting the occurrence of TIC. Subsequently, a predictive model for TIC was established. Finally, the predictive model was evaluated, and a clinical application decision tree was constructed.
Results
A total of 214 patients were included. Hemoglobin, prothrombin time (PT), fibrinogen (Fbg), base excess (BE), lactic acid, and LnD-dimer levels were associated with TIC. Further analysis showed that PT, Fbg level, BE level, and LnD-dimer level were independent risk factors of TIC. Based on these parameters, the TIC prediction model was established. The model displayed excellent discrimination (area under the curve: 0.877; 95% confidence interval: 0.827–0.988). The cut-off value was-0.705. Model scores≥-0.705 indicated the existence of TIC, and patients with these scores were considered the high-risk group. The incidence of TIC was significantly different between the high- and low-risk groups (90.4% vs. 25.6%, p < 0.001).
Conclusion
Our study developed a prediction model to guide early effective interventions of TIC and improve the prognosis in severe trauma patients.
Successful collection of patient-reported outcomes shows improvement in quality of life, depression, and disease activity among patients with Inflammatory Bowel Disease: A real-world study
Authors: Gu Cihang , Bennett Audrey , Bachmann Justin , Schwartz David A. , Beaulieu Dawn , Scoville Elizabeth , Dalal Robin , Pabla Baldeep , McCoy Allison , Slaughter James C. , Horst Sara
Published: December 2024

Introduction:
Patient reported outcomes (PRO) including patient disease activity scores, quality of life, and depressive symptoms are increasingly being used for clinical care in patients with inflammatory bowel disease (IBD). However, little is known about performance of PROs over time in a real-world setting.
Methods:
PROs were collected from a tertiary care IBD center from the electronic medical records (EMR) from 2018–2020. Quality of life was measured with the Simple Inflammatory Bowel Disease Questionnaire (SIBDQ). Disease activity was measured using the Harvey Bradshaw Index (HBI) for Crohn’s disease (CD) and the Simple Clinical Colitis Activity Index (SCCAI) for ulcerative colitis (UC). Depressive symptoms were measured using the Patient Health Questionnaire-8 (PHQ-8).
Results:
PRO collection rate from 1,373 patients was 88%. PHQ and SIBDQ were highly correlated (0.718, p < 0.05). HBI and PHQ-8 (0.528, p < 0.05) and SIBDQ (-0.676, p < 0.05) were moderately correlated. For CD patients, age 40–65, corticosteroid use, and psychiatric medication use were associated with lower HBI and SIBDQ and higher PHQ scores. Age 40–65, corticosteroid use, and psychiatric medication use were associated with lower SCCAI and SIBDQ and higher PHQ-8 scores for CD and UC patients. Mean change [95% CI] increased for SIBDQ by 2.9 [2.3 to 3.6] in CD and 4.7 [3.8 to 5.6] in UC. Mean change [95% CI] decreased for PHQ-8: -1.0 [-1.3 to -0.8] in CD and − 1.7 [-2.2 to -1.3] in UC. This remained significant in both cognitive and somatic subscales.
Conclusion:
PRO collection was highly successful using EMR implementation in a tertiary care clinic setting. Corticosteroid use and psychiatric medication use were associated with worse disease activity, depressive symptom and quality of life scores. Moreover, PROs demonstrated depressive symptoms (both cognitive and somatic subscales), and quality of life symptom scores improved over time.
Combined metabolome and transcriptome to analyze the regulatory network of key enzymes in the synthesis of Senkirkine in Emilia sonchifolia
Authors: Yao Jinli , Qin Yanqing , Tu Dongping , Huang Yumei , Liang Liuguan , Cai Wenhui , Huang Mingli , Zhu Xiaoqi , Lao Xinling
Published: December 2024

Emilia sonchifolia (L.) DC. is a commonly used medicinal and edible plant in the folk, and its toxic component of Senkirkine (Sek) has hepatotoxicity, which can lead to sinusoidal obstruction syndrome if exposed in large amounts, and will cause hepatic megaloblastosis and hepatic fibrosis if ingested in small amounts over a long period of time. This study was based on the metabolomics of Emilia sonchifolia, which analysed and identified the alkaloid constituents of 4 parts of Emilia sonchifolia, namely, the root, stem, leaf and flower. A total of 91 differential metabolites were detected, belonging to 10 alkaloids, among which pyrrolizidine alkaloids accounted for 13%. The relative content of Senkirkine differed most significantly between the group of root and flower comparison, and the relative content of Senkirkine in root was significantly higher than in flower. A total of 119,886 unigenes and 32,797 differentially expressed genes were identified in the transcriptome data, and the 45 key enzymes of the biological synthesis pathway of Senkirkine were selected, which belonged to 7 categories. There are a total of 172 candidate enzyme genes in it, of which methyltransferase, alcohol dehydrogenase, acyltransferase, and cyclooxygenase genes were significantly more expressed in roots than in flowers, and the metabolome and transcriptome expression patterns were basically the same. The 5 key enzyme gene sequences of the biological synthesis pathway of Senkirkine were selected for qRT-PCR. The results showed that, using flowers as the control group, 4 key enzyme genes (BAHD-Ats, CCoAOMT, BOMT, 3AT) were all highest in roots, while the relative expression of CAD was highest in stems, which was basically consistent with the transcriptome pattern. This study provided a reference for the functional expression analysis of the genes of Emilia sonchifolia, and laid a foundation for the future analysis of the Senkirkine synthesis pathway and the regulation of the key enzyme genes of the toxic components, so as to obtain the low-toxic raw materials of Emilia sonchifolia.
The Use of Endoscopic Ultrasound Guided Fine Needle Biopsy for the Diagnosis of Microcystic Serous Cystic Neoplasms of the Pancreas
Authors: Garg Kanika , Boupapanh Kesany , Zilberstein Netanel , Wang Thomas , Kakked Gaurav , Al-Sabti Ram , Mehta Neal , Chapman Christopher , Waxman Irving , Singh Ajaypal
Published: December 2024

Background: Pancreatic cysts, frequently identified incidentally on imaging, present diagnostic challenges due to their variable malignant potential. Serous cystic neoplasms (SCNs) are benign and account for 1-2% of pancreatic lesions. However, imaging techniques alone often lack the accuracy to definitively diagnose these lesions, leading to unnecessary surveillance and interventions.
Aims: This study evaluates the safety and diagnostic efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) for identifying microcystic SCNs.
Methods: We conducted a retrospective analysis of 39 patients who underwent EUS-FNB for solitary pancreatic lesions with microcystic features, identified through cross-sectional imaging at our medical center between 2018 and 2024. Patients with a stellate scar or definitive imaging features of microcystic SCNs were excluded. Outcomes assessed included histologic results and complications.
Results: Histological confirmation of microcystic SCN was achieved in 79.5% of cases, eliminating the need for further imaging and surveillance. A single complication—mild intra-lesional bleeding—occurred in one patient, which resolved without further intervention.
Conclusions: EUS-FNB is a safe and effective method for diagnosing microcystic SCNs, offering a definitive diagnosis and reducing unnecessary surveillance and interventions. This approach provides a favorable risk-benefit profile for managing SCNs. However, future multicenter studies with larger cohorts are needed to further validate these findings and refine diagnostic protocols for pancreatic cystic neoplasms.
Quantum-Powered Personalized Learning
Authors: Zhou Yifan , Xh Chong Cheng , Song Mingi , Wong Yew Kee
Published: December 2024

This paper explores the transformative potential of quan- tum computing in the realm of personalized learning. Tradi- tional machine learning models and GPU-based approaches have long been utilized to tailor educational experiences to individual student needs. However, these methods face significant challenges in terms of scalability, computational efficiency, and real-time adaptation to the dynamic nature of educational data. This study proposes leveraging quantum computing to address these limitations. We review existing personalized learning systems, classical machine learning methods, and emerging quantum computing applications in education. We then outline a protocol for data collection, privacy preservation using quantum techniques, and prepro- cessing, followed by the development and implementation of quantum algorithms specifically designed for personalized learning. Our findings indicate that quantum algorithms of- fer substantial improvements in efficiency, scalability, and personalization quality compared to classical methods. This paper discusses the implications of integrating quantum com- puting into educational systems, highlighting the potential for enhanced teaching methodologies, curriculum design, and overall student experiences. We conclude by summariz- ing the advantages of quantum computing in education and suggesting future research directions.
Hybrid Red Fox and Remora Optimization Algorithm Expedites Optimal Load Balancing in Cloud Computing
Authors: Umrao Lokendra Singh , Mishra Chandra Mani
Published: December 2024

Cloud task scheduling poses a complex optimization challenge due to dynamic nature of the cloud system and varying user demands. The system's load, determined by the cloud architecture and user requirements, can lead to failures such as increased power consumption and machine failures when the system is either under loaded or overloaded. Consequently, achieving task-load balancing on virtual machines (VMs) becomes crucial in cloud task scheduling to mitigate these issues. In this manuscript, proposed the Hybrid Red Fox and Remora Optimization Algorithm Expedites Optimum Load Balancing in Cloud Computing (HYB-RF-RO-LB-CC) to address the load equalizing problem in cloud networks. By incorporating the Red fox optimization algorithm (RFOA) into Remora Optimization Algorithm (ROA), achieve a useful load balancing algorithm. The proposed method focuses on identifying the optimal under load that considers multiple objective functions, like cost, response time, and resource utilization, ultimately minimizing the fitness function of load equalizing. The process HYB-RF-RO-LB-CC effectively assesses and balances the load of each virtual machine (VM) using fitness function. The proposed HYB-RF-RO-LB-CC approach is executed in CloudSim tool. The performance of the proposed HYB-RF-RO-LB-CC approach attains 3.101%, 7.12% and 6.7% higher makes span, 24.13%, 13.04% and 17.81% minimum energy utilization, 5.262%, 8.375% and 7.945% better throughput compared with existing methods such as Harris Hawk Optimization (HHO), Manta Ray Forging Optimization (MRFO) approach and Grey Wolf Optimization (GWO) algorithm respectively.
A Semi-Empirical Model for Fracture Energy Evaluation of a Ni2MnGa Magnetic Shape Memory Alloy
Authors: D'Silva Glen , Ciocanel Constantin
Published: December 2024

Ni2MnGa magnetic shape memory alloys (MSMAs) experience the shape memory effect due to magnetic field-induced or mechanical stress-induced microstructure reorientation. Crack nucleation and growth in Ni2MnGa is impacted by the alloy's evolving twin microstructure under magneto-mechanical loading conditions, eventually hampering its function in applications. This study reports on the evaluation of the fracture energy of a Ni2MnGa alloy under various magneto-mechanical loading conditions. The fracture energy of the alloy was evaluated through Vickers microindentation experiments that allowed the investigation of crack nucleation and growth under various magneto-mechanical loading conditions. The length of the cracks and the dimensions of the microindentation impressions were used to develop a semi-empirical relationship that predicts the fracture energy of the alloy as a function of magneto-mechanical loading conditions. The results confirm that the magnetic field (particularly the transversely applied magnetic field) facilitates crack growth, decreasing the fracture energy, while axial compressive stress impedes crack growth, increasing the fracture energy of the alloy. The proposed empirical relationship for the evaluation of fracture energy helps identify the magneto-mechanical loading conditions that are least conducive to fracture initiation and growth in MSMAs.
Modelling the Efficiency of Transportation Survey Recruitment and Reminder Methods
Authors: Davanzo Elis , Orvin Muntahith Mehadil , Fatmi Mahmudur Rahman
Published: December 2024

Transportation surveys are vital to generating data for informed infrastructure investment decision-making, developing travel demand models, and monitoring progress. By employing diverse recruitment and data collection strategies, it is possible to improve the overall effectiveness and accuracy of the surveys. With this motivation, this paper examines the efficiency of various survey recruitment and reminder methods. The dataset comes from a time-use survey deployed in Province of British Columbia, which utilized mail and self-registration as recruitment methods. In case of reminders, we used several methods including telephone calls, SMS, emails and social media postings. To further identify factors that influence the effectiveness of reminders and no reminders towards survey completion rates, statistical models are developed. Specifically, an ordered logit model is developed to examine households' need for frequent reminders to complete the survey. Additionally, a hazard model is developed to investigate the time it takes for the households to complete the survey without any reminders. Results indicate that among the self-registrants, about 69% of households that received an SMS completed the survey on the same day, with approximately 40.5% finishing within one hour. Results also revealed that self-registrants, older adults and single individuals are more likely to need more frequent communication to finalize the survey. In contrast, without reminders, residents of Metro Vancouver tend to complete surveys more quickly, while full-time workers may require more time. The findings of this study evaluate the effectiveness of various recruitment methods and reminder techniques, aiding in better targeting and communication to improve response rates.
Synthesis, characterization, and biological activity assessment of quaternary ammonium- functionalized cellulose: Enhancing antimicrobial features, free radical scavenging property, and thermal stability
Authors: Xuang Xin , Ganie Showkat Ali , Rather Luqman Jameel , Mir Shazia Shaheen , Assiri Mohammed A. , Mady Mohamed F. , Li Qing
Published: December 2024

The incorporation of chemical entities that confer antimicrobial properties represents a novel direction in cellulose material modification. This innovative strategy expands the potential applications of cellulose-based materials, particularly in sectors where antimicrobial efficacy is paramount. Through meticulous synthesis and characterization, we elucidate the structural and functional attributes of the modified cellulose, paving the way for its utilization in diverse biomedical settings. This study reports the successful synthesis and characterization of quaternary ammonium iodide salt of cellulose along with other intermediates using a comprehensive array of instrumental (SEM and TGA) and spectroscopic (FT-IR and NMR) techniques. The chemical functionalization of cellulose was accomplished through the process of tosylation, amination, and subsequent quaternization with ethylenediamine. The method used in this research pays way for cellulose modification under alkaline medium (H2O/NaOH/triethylamine) at a low temperature (5 oC) and time (5 h). A thorough assessment of the structural characterization and stability of the components revealed that the modified cellulose demonstrated superior antibacterial properties (disc diffusion assay), accompanied by improved thermal properties. The inhibition patterns clearly show the potency of synthesized cellulose derivative with 100% inhibition of bacterial strains at 16 mg/L concentration for both E. coli (gram negative) and S. aureus (gram positive). The potential free radical-scavenging mechanism, including the quantity of hydroxyl groups and the existence of ortho dihydroxy substitution for antioxidant efficacy, was examined. The quaternized group of cellulose adds to its antioxidant activity, as shown by our data, which indicated that the antioxidant abilities were in the order of Q-cell > cellulose. Consequently, Q-cell has significant antioxidant activity and may serve as a potential material in the food and pharmaceutical sectors.
Harnessing Protein Language Model for Structure-Based Discovery of Highly Efficient and Robust PET Hydrolases
Authors: Zheng Lirong , Wu Banghao , Zhong Bozitao , Huang Runye , Jiang Shifeng , Li Mingchen , Tan Pan , Hong Liang
Published: December 2024

Plastic waste, particularly polyethylene terephthalate (PET), poses significant environmental challenges, prompting extensive research into enzymatic biodegradation. However, existing PET hydrolases (PETases) are constrained to a narrow sequence space and exhibited limited performance for effective biodegradation. This study introduces a protein discovery pipeline, ProMine, which integrates protein language models (PLMs) with a representation tree to identify PETase based on structural similarity using sequence information. Using the crystal structure of IsPETase as a template, we employed ProMine to search for and cluster target proteins. PETase candidates were further screened using PLM-based assessments of solubility and thermostability, leading to the selection of 34 proteins for biochemical experiments. The results showed that 14 candidates exhibited PET degradation activity across a temperature range of 30-60 ℃. Notably, we identified a PET hydrolase from Kibdelosporangium banguiense (KbPETase), which has a melting temperature 32 ℃ higher than that of IsPETase and exhibits the highest PET degradation activity within 30-60 ℃ compared to other wild-type PETases. KbPETase also shows higher catalytic efficiency than FastPETase. X-ray crystallography and molecular dynamics simulations revealed that KbPETase has a conserved catalytic domain and enhanced intramolecular interactions, contributing to its improved functionality and thermostability. This work demonstrates a novel deep learning approach for discovering natural PETases with enhanced properties.
Immediate Redo Hepatic Artery Reconstruction in Living Donor Liver Transplantation
Authors: Zafar Muhammad
Published: December 2024

Background: In living donor liver transplant, vascular complications by compromising the blood flow to the graft can have significant and sometimes might lead to life-threatening consequences for the patient.
Aim: To evaluate the practice of immediate redo hepatic artery reconstruction in living donor liver transplant.
Methods: Across sectional study (June 2003-August 2015) included recipients with hepatic artery complication who underwent living donor liver transplantation at Chang Gung Memorial Hospital, Kaohsiung, Taiwan. Intraoperative complications necessitating immediate redo reconstruction of hepatic arterywere recorded. Vascular patency was evaluated by intraoperative and postoperative Doppler Ultrasonography. Immediate redo reconstruction was carried out when either arterial wall problem or low flow or RI less than 0.55. Late redo reconstruction (> 24 hours) was carried out to patients developed HAT postoperatively. The data was analyzed by SPSS version 21. P value less than 0.05 was regarded as significant.
Results: A59 recipients developed hepatic artery complication,and underwent redo reconstruction with incidence of 6.6%. Immediate redo reconstruction was performed in 86.4%, and 13.6% underwent late redo reconstruction (>24 hours). Minimal discrepancy was encountered in 71.2%, and there was significant correlation between discrepancy and RI, (p=0.048). RI <0.55 was seen in 25.4%. There was significant difference in the outcome between the groups of patient managed by early versus late HA redo reconstruction, (p=0.031).
Conclusion: Preliminary results show that immediate redo HA reconstruction preserving blood flow, maintaining perfusion and preventing post-transplant graft loss.
WITHDRAWN: Investigation of Factors Affecting Digital Game Addiction in 10-14 Age Group Children
Authors: Güler Funda , Gün Canan Sümeyra , Yıldırım Öznur , Çalışır Hüsniye
Published: December 2024

Children and adolescents constitute the risk group for digital game addiction, which is becoming widespread and an important public health concern.
The current study was conducted to determine the factors contributing to the development of digital game addiction in children and adolescents aged 10-14 years enrolled in secondary schools.
The data were completed with the participation of 151 students between March 20, 2021 and March 19, 2022.
The analysis showed that playing computer games at home made a significant difference in the levels of digital game addiction in boys as gender and in the 10-11 age group as age group.
Based on the findings, pediatric nurses should investigate the negative impact of digital games on child development and provide education and counseling for the child and his/her family through education, counseling, supportive and advocacy roles.
Jan Paweł Kaczkowski : Bibliographie
Authors: Grzelak Tomasz Jerzy
Published: December 2024

Die Bibliographie verzeichnet monographisch erschienene Übersetzungen Kaczkowskis. Die Titelangaben wurden autoptisch erfasst; für einzelne Ausgaben sind Informationen zu Begleittexten bzw. Fußnoten und Anmerkungen verzeichnet.
Wolf von Kalckreuth : Bibliographie
Authors: Heyer Theresa
Published: December 2024

Die Bibliographie erfasst alle selbständig erschienenen sowie möglichst viele in Anthologien veröffentlichte Übersetzungen Kalckreuths. Die meisten Titel konnten autoptisch überprüft werden. Die Sekundärliteratur ist bis zum Jahr 2015 verzeichnet.
New Sightings and Habitat Suitability Mapping of Endemic Platyceps gracilis (GÜNTHER, 1862)
Authors: Sharma Vivek , Choudhary Rounak , Dutta Subroto , Singh Pawan , Kumar Kumawat Rakesh , Kumar Sharma Krishan
Published: December 2024

This study presents updated observation data and mapping of habitat suitability for the endemic snake species Platyceps gracilis (GÜNTHER, 1862). The objective is to improve understanding of its distribution patterns and conservation needs. Observations from field surveys supplemented by literature reviews and citizen science contributions were used in mapping the habitat suitability using Maxent software across Indian subcontinent. Our findings enhance the extent of its known distribution and provide insight into its preferred habitat. regions with a high potential for P. gracilis occurrence were identified by habitat suitability mapping, emphasizing priority regions for conservation efforts.
Wisdom with Age: Ayurvedic and Modern Approaches to Positive Aging
Authors: Zope Rakesh Anil
Published: December 2024

This article takes a look at views on aging through Ayurvedic and modern perspectives. Aging is often seen negatively in society, but Ayurveda views it as a natural process and also offers therapies like Rasayana to promote longevity and well-being. In Ayurvedic approach emphasis is given to balance physical and mental health. Attention is given to addressing the dominance of Vata in old age. Modern research aligns with these concepts. It shows that a positive mindset improves mental and physical health in older adults. The article highlights the confluence of ancient Ayurvedic wisdom and contemporary science. It emphasizes the importance of respecting the wisdom of the elderly and aging gracefully.
Acridone Derivatives as Photosystem II Inhibitors: Synthesis, Herbicidal Activity, and Structure-Activity
Authors: de Souza Jessica Maria , S. Medeiros Paulo , S. Pitteri Taciane , Silva Mariana A. , F. Basso Marcelo Augusto , de Vasconcelos Leonardo G. , Luiz Dall'Óglio Evandro , M. Sampaio Olívia , C. C. Vieira Lucas
Published: December 2024

In this study, we report the synthesis of acridone derivatives and their potential as
photosystem II (PSII) inhibitors, as well as their pre- and post-emergence herbicidal activities
through chlorophyll a fluorescence and germination assays. Among the compounds tested for
PSII activity, acridin-9(10H)-one showed the most promising results, reducing the performance
index on an absorption basis and decreasing the quantum yield for electron transport compared
to the control. These findings suggest an inhibitory effect on PSII within the electron transport
chain. Additionally, 2-chloroacridin-9(10H)-one and 9(10H)-acridone-4-carboxylic acid exhibited
post-emergence herbicidal activity against Amaranthus lividus and Amaranthus viridis weeds,
respectively, leading to a reduction in radicle and hypocotyl lengths. Furthermore, we applied
a molecular docking approach with the D1 protein and 4-hydroxyphenylpyruvate dioxygenase
to investigate the structure-activity relationships among the acridone derivatives with these
enzymes. The analysis highlighted the importance of the carbonyl group and aromatic substituents
on the acridone scaffold facilitating ligand interactions, especially through hydrogen bonding.
Consequently, our research group aims to optimize these molecular features to develop new, potent
bioactive molecular scaffolds.
A review of evapotranspiration estimation methods for climate-smart agriculture tools under a changing climate: vulnerabilities, consequences, and implications
Authors: Lakhiar Imran Ali , Yan Haofang , Zhang Chuan , Zhang Jianyun , Wang Guoqing , Deng Shuaishuai , Syed Tabinda Naz , Wang Biyu , Zhou Rui
Published: December 2024

Climate change (CC) seriously threatens global water resources, exacerbating extreme water scarcity issues, especially in agriculture. Evapotranspiration (ET) is one of the essential components of the water cycle and is particularly sensitive to CC. Thus, this study presents an overview of the importance of ET estimation as climate-smart agriculture (C-SA) and its relevance in addressing CC's challenges. We adopted a systematic review methodology to select the relevant literature based on predefined inclusion and exclusion criteria. Based on the analysis, we found that CC has significantly affected the yield of various crops and changed the ET over time. Besides, C-SA tools are vital for addressing the challenges of CC. Its adoption in traditional agriculture can build strong resilience against threats posed by CC. In addition, significant development has been attained in the precision monitoring of the ET from agriculture fields, ranging from direct and indirect to more sophisticated energy balance and modern techniques. However, the accuracy of each method mainly depended on the specific regional climate conditions. In the absence of actual field measurements, empirical or modern models are helpful to estimate ET using routine meteorological variables. Yet, these models require local calibration for the best accuracy.
Gazze’de sağlık sistemi ve bu sistemle entegre bir sivil toplum kuruluşu: 7 Ekim öncesi ve sonrasına ilişkin Yeryüzü Doktorları Derneği deneyimi
Authors: Salduz Ahmet , Şimşekoğlu Muhammed Fatih , Yandır Gonca
Published: December 2024

Ülkeler insani krizlerle mücadele etmek ve bu krizlerin yol açtığı sorunları gidermek üzere ellerindeki imkanlar çerçevesinde çeşitli mekanizmalara başvururlar. Yeryüzünde sağlık sistemleri oturmuş, yeterli sağlık profesyonellerine sahip ülkeler olmakla birlikte insani krizler ve doğal afetler karşısında kırılgan sağlık sistemlerine sahip ülkeler de bulunmaktadır. Özellikle bu kırılgan ülkelerde devletin sivil toplum ile sıkı uyumu insani krizlerin üstesinden gelme adına önem arz etmektedir. Olağandışı durumlarda bir yandan ülkeler kendi içlerindeki yetki, uzmanlık alanı ve kapasiteye bağlı olarak geniş bir yelpazede faaliyet gösterirken sivil toplum kuruluşları da sahada önemli bir aktör olarak belirmektedir. Özellikle Türkiye’de ciddi anlamda kurumsallaşma, profesyonelleşme ve operasyon kabiliyeti kazanmış olan sivil toplum kuruluşları 90’lı yıllardan bu yana ülkemizde ve Ortadoğu’da yaşanan krizlerde de aktif rol aldılar. Bu kuruluşlar acil yardım, gıda, sağlık, eğitim, kalkınma gibi birçok alanda etkin organizasyonlarla birçok konuda yadsınamaz katkılarda bulundular.
Bu derleme, Gazze’nin sağlık sisteminin 7 Ekim 2023 sonrasında toplumun içine sürüklendiği insani kriz karşısında işlevsiz kalması ve bölgede insani yardım hizmeti veren aktörler arasında yer alan Yeryüzü Doktorları Derneği’nin insani krizi önlemedeki rolünü analiz etmeyi hedeflemektedir. Ek olarak Yeryüzü Doktorları Derneği’nin 2000’li yıllardan itibaren Gazze’nin sağlık sistemine entegre olma süreçlerinden başlayarak günümüze kadar doğrudan insan hayatının korunmasına yönelik çalışmaları aktarılmaktadır.
Evaluation of cocoa farmers’ perception of the cocoa rebirth program in Kwara State, Nigeria
Authors: KAYODE Ajoke O. , MUSA Mobolaji O. , OLADIMEJI Abdulhakeem A.
Published: December 2024

El cacao, un cultivo comercial significativo en Nigeria, contribuye al crecimiento económico de la nación. Sin embargo, el declive de la producción de cacao es preocupante, por lo tanto, existe la necesidad de reiniciar la industria del cacao a través del Cocoa Rebirth Program (CRP). El estudio describe las características socioeconómicas de los productores de cacao, determina el nivel de práctica de la CRP, describe la actitud de los agricultores de cacao hacia la CRP e identifica las limitaciones contra la adopción de CRP en el estado de Kwara, Nigeria. Se utilizaron estadísticas descriptivas, análisis de regresión múltiple y correlación de momento del producto Pearson para analizar los datos. Los resultados revelaron que la edad media de los agricultores, la experiencia agrícola y el tamaño de la granja fueron 52.4 años, 23.3 años y 1.74 hectáreas, respectivamente. El nivel de práctica de los programas de agua sostenibles fue alto. Reconocer la importancia de los programas de renacimiento de cacao tiene la puntuación media más alta en 4.23, lo cual es crucial para la viabilidad a largo plazo de la industria del cacao. Los encuestados tuvieron una actitud positiva hacia CRP con x̄ = 2.19. El acceso al mercado y la volatilidad de los precios (x̄ = 2.63) y la vulnerabilidad del cambio climático (x̄ = 2.54) fueron restricciones significativas para la práctica de la PCR. La edad de los agricultores (β = –0.122), años de educación (β = –0.412), años de experiencia (β = –0.045) y frecuencia de contacto de extensión (β = 0.011) determinaron la actitud de los agricultores hacia la percepción de la CRP. El estudio concluyó que la percepción de los agricultores de cacao en la CRP es apreciable en el área de estudio. Los hallazgos subrayan la necesidad de más investigación sobre CRP y el cacao, con el apoyo de otros institutos de investigación agrícola se debería explorar las variedades de cacao resistentes a las plagas y enfermedades, y de alto rendimiento.
Detecção de fraudes em queijo de manteiga e em manteiga de garrafa do rio grande do norte
Authors:   , Linhares Manuella de Oliveira Cabral Rocha
Published: December 2024

O queijo de manteiga e a manteiga de garrafa são produtos tradicionais e muito consumidos no Nordeste do Brasil. Além disso, têm muita relevância para o crescimento socioeconômico da região. A maioria desses produtos são fabricados artesanalmente, por pequenos produtores, que podem realizar práticas inadequadas de higiene e adição de ingredientes não permitidos pela legislação. Assim, objetivou-se avaliar a qualidade microbiológica, físico-química e detecção de possíveis fraudes em queijos de manteiga e em manteigas de garrafa comercializados no Rio Grande do Norte. Para isso, foram adquiridas 30 amostras de queijos de manteiga e 30 de manteigas de garrafa em supermercados, queijeiras, padarias, feiras livres e em rodovias do Rio Grande do Norte. As amostras foram submetidas as análises microbiológicas (Coliformes a 35 e 45 ºC, Estafilococos coagulase positiva e Salmonella spp.), físico-químicas (umidade, gordura, pH, cloretos, acidez), teste do Lugol (só para queijos) e o perfil dos ácidos graxos em cromatografia gasosa. Observou-se que 87% e 33% das amostras de queijo e manteiga de garrafa, respectivamente, apresentaram contagens elevadas para Estafilococos coagulase positiva. Apenas uma amostra de queijo apresentou presença para Salmonella spp. Nos queijos foram obtidos resultados médios para umidade de 43,79%, gordura 26,70%, pH 4,81, cloretos 8,07% e acidez 1,53%. Para as manteigas foram obtidos resultados médios para umidade de 0,28%, gordura 98,38%, sólidos não gordurosos 1,34%, pH 4,65, cloretos 0,05%, sólidos totais 99,70% e acidez 0,26%. Foram detectadas a presença do amido em 6 (20%) das amostras de queijos. Para o perfil dos ácidos graxos observou-se que 83% dos queijos e 50% das manteigas apresentaram percentual de ácido linoleico acima de 3% que é a média encontrada no leite. Assim, conclui-se que os queijos de manteiga e as manteigas de garrafa apresentaram qualidade microbiológica indesejável, bem como a detecção de fraudes por adição de amido e por substituição de gordura animal láctea por óleo vegetal, considerando a elevada porcentagem de ácido linoleico encontrada nas amostras
Parâmetros físicos dos atuns capturados em cardumes associados pela frota de pequena escala no atlântico oeste equatorial
Authors:   , Rebouças Lucas de Oliveira Soares
Published: December 2024

O grupo dos atuns e afins constituem um importante recurso pesqueiro mundial, normalmente a pesca de atuns é caracterizada pela predominância do segmento industrial, sendo realizada por grandes embarcações, com alto nível tecnológico, para a captura, armazenamento e processamento a bordo. No Nordeste com o esgotamento dos estoques tradicionalmente explotados, grande parte da frota pesqueira artesanal está sendo adaptada na busca de pescarias alternativas, como a dos atuns. A grande problemática da pesca artesanal se encontra na baixa qualidade do pescado, devido ao baixo acesso à tecnologia e ausência de medidas de boas práticas de manipulação a bordo por parte dos pescadores. O objetivo deste trabalho é avaliar a qualidade dos atuns capturados em frota artesanal no atlântico oeste equatorial, identificando quais são os fatores a bordo que são importantes para determinação da qualidade dos peixes. Para isso, foram realizados seis (06) embarques durante um ano em frota artesanal do município de Areia Branca – RN. As variáveis analisadas ainda a bordo foram, comprimento furcal, espécie, temperatura inicial, pH inicial, dias de gelo, tempo de convés e método de abate. Ao desembarcar, os peixes foram levados para o Laboratório de Análises Sensoriais e Instrumentais da UFERSA para o prosseguimento das análises. As variáveis de qualidade analisadas foram, pH, luminosidade (L*), teor de vermelho (a*), teor de amarelo (b*), capacidade de retenção de água (%), perda de peso pós-cocção e força de cisalhamento. A análise de componentes principais (ACP) foi utilizada para verificar quais varáveis são importantes para determinação da qualidade dos atuns. A relação entre as variáveis, foram analisadas através de análises de regressão simples, com correlação de Pearson, afim de verificar se houve correlação (negativa/positiva) entre as variáveis. Os dois primeiros componentes principais da ACP responderam quase 70% da variância. Onde, o comprimento furcal, dias de gelo e tempo de convés foram as principais variáveis a bordo responsável pela determinação da qualidade final dos atuns
Role of a Dual Inhibitor of RAS/PI3K/AKT and RAS/RAF/MEK on
Post-surgical Adhesion Band Formation
Authors: Soleimani Atena , Asgharzadeh Fereshteh , Saeedi Nikoo , Avan Amir , Ryzhikov Mikhail , Khazaei Majid , Mehr Seyed Mahdi Hassanian
Published: December 2024

Introduction:

This study evaluated the effects of Rigosertib (RGS) on the prevention of
intra-abdominal adhesions in a mouse model.

Methods:

Eighteen mice were divided into three groups: Sham (no abrasion or adhesion), Positive
Control (surgical abrasion and adhesion), and Rigosertib Treatment (200 mg/kg/day intraperitoneally
for 7 days). Adhesions were induced through cecal abrasion and assessed using Nair and Leach adhesion
scoring systems. Histological evaluations were performed using Haematoxylin & Eosin (H &
E) and Masson's trichrome stains in order to analyze inflammatory cell infiltration and collagen deposition.

Results:

Results showed that RGS administration did not have a significant impact on the formation
or rigidity of adhesion bands compared to the positive control group. Both Nair and Leach scoring
systems confirmed the lack of significant differences. Histological analysis revealed no reduction in
inflammatory responses or collagen deposition in RGS-treated mice. H & E staining showed similar
inflammatory cell infiltration across all groups, while Masson's trichrome staining indicated no differences
in fibrosis levels between treated and untreated mice. In conclusion, Rigosertib did not
demonstrate efficacy in down-regulating peritoneal adhesions or associated inflammatory responses
and fibrosis in this mouse model.

Conclusion:

These findings suggest that Rigosertib may not be suitable for preventing intraabdominal
adhesions, warranting further investigation into alternative therapeutic strategies.
Gender Interaction: Exploring How Shopee Mobile Technology Shapes Consumer Decisions Through the Lens of Consumer Enjoyment
Authors:   Departement of Management, Tadulako University, Indonesia, Talita Febrina , Wahyuningsih Wahyuningsih ,   Departement of Management, Tadulako University, Indonesia, Santi Ira Nuriya ,   Departement of Management, Tadulako University, Indonesia
Published: December 2024

The evolution of e-commerce from simple websites that facilitate sales transactions to integrated mobile apps has been fuelled by a significant surge in user demand. This transformation, marked by the dominance of mobile devices in accessing e-commerce platforms such as Shopee, underscores the importance of understanding consumer behavior and preferences in the context of mobile shopping. The findings of this study provide valuable insights into how perceived usefulness (PU) and perceived ease of use (PEOU), as well as gender, influence purchasing decisions on Shopee Mobile. We conducted an online survey using Google Forms to collect the research data. A total of 210 respondents were successfully obtained and processed the data. The survey respondents are Shopee Mobile application users who live in Palu City. The PLS SEM 3 data analysis method employs the JASP tool for data processing. The study's results show that perceived usefulness and perceived ease of use do not significantly influence purchase decisions. However, when mediated by consumer enjoyment, perceived usefulness and perceived ease of use significantly influence purchase decisions; the moderating effect of gender is not significant. The findings of this study are very useful for managers or company leaders in developing technological application innovations to increase the number of application users and can influence consumer choices in making purchasing decisions.