bluuebunny/crossref_metadata_2025 huggingface dataset:
WITHDRAWN: Salinity stress effects on growth and performance of drip-irrigated sweet potato varieties under the Mediterranean conditions
Authors: Doganay Kivanc Hayri , Kurunc Ahmet , Dincer Cuneyt
Published: February 2022

There is numerous scientific research on yield response of different sweet potato varieties under salinity stress, but no studies on the Koganesengan and Beniazuma varieties have been found in the literature. The aim of this study was to investigate the effects of irrigation salinity levels on growth, yield and quality parameters of these two sweet potato varieties under drip irrigation. Salinity levels had a substantial impact on some growth and yield parameters of ‘Beniazuma’, but not on those of ‘Koganesengan’. Irrigation salinity levels only influenced the crude fiber content and antioxidant activity of ‘Koganesengan’ and ash, starch, ß-carotene, and ascorbic acid contents of ‘Beniazuma’. Some growth and yield quality parameters showed significant differences between varieties under salinity level(s), and all yield parameters (except dry vine yield) only under control treatment. Under the same salt stress levels, the values of the examined parameters were greater in ‘Beniazuma’ than in ‘Koganesengan’. The salinity threshold and slope values, on the other hand, suggest that ‘Beniazuma’ is more vulnerable to salt stress than ‘Koganesengan’. As a result, sweet potato growers in the Mediterranean region should consider both the salt response and the productivity of these sweet potato varieties under drip irrigation with saline water.
Validation of an electronic frailty index with electronic health records: eFRAGICAP index
Authors: Pernas Francesc Orfila , Carrasco-Ribelles Lucía A. , Abellana Rosa , Roso-Llorach Albert , Cegri Francisco , Reyes Carlen , Violán Concepción
Published: February 2022

Objective: To create an electronic frailty index (eFRAGICAP) using electronic health records (EHR) in Catalunya (Spain) and assess its predictive validity with a two-year follow-up of the outcomes: homecare need, institutionalization and mortality in the elderly. Additionally, to assess its concurrent validity compared to other standardized measures: the Clinical Frailty Scale (CFS) and the Risk Instrument for Screening in the Community (RISC).Methods: The eFRAGICAP was based on the electronic frailty index (eFI) developed in United Kingdom, and includes 36 deficits identified through clinical diagnoses, prescriptions, physical examinations, and questionnaires registered in the EHR in of primary health care centres (PHC). All subjects >65 assigned to a PHC in Barcelona on 1st January, 2016 were included. Subjects were classified according to their eFRAGICAP index as: fit, mild, moderate or severe frailty. Predictive validity was assessed comparing results with the following outcomes: institutionalization, homecare need, and mortality at 24 months. Concurrent validation of the eFRAGICAP was performed with a sample of subjects (n=333) drawn from the global cohort and the CFS and RISC. Discrimination and calibration measures for the outcomes of institutionalization, homecare need, and mortality and frailty scales were calculated. Results: 253,684 subjects had their eFRAGICAP index calculated. Mean age was 76.3 years (59.5% women). Of these, 41.1% were classified as fit, and 32.2% as presenting mild, 18.7% moderate, and 7.9% severe frailty. The mean age of the subjects included in the validation sample (n=333) was 79.9 years (57.7% women). Of these, 12.6% were classified as fit, and 31.5% presented mild, 39.6% moderate, and 16.2% severe frailty. Regarding the outcome analyses, the eFRAGICAP was good in the detection of subjects who were institutionalized, required homecare assistance, or died at 24 months (c-statistic of 0.841, 0.853, and 0.803, respectively). eFRAGICAP was also good in the detection of frail subjects compared to the CFS (AUC 0.821) and the RISC (AUC 0.848).Conclusion: The eFRAGICAP has a good discriminative capacity to identify frail subjects compared to other frailty scales and predictive outcomes.
A perspective of matrix metalloproteases gene expression profile revealed by pan-cancer transcriptome and single cell data
Authors: Tan Jinxiang , Wang Linbang , Gao Yidan , Li Zhao , Wang Yuanyuan , Wang Lu
Published: February 2022

Background: Matrix metalloproteases (MMPs) are encoded by a family of genes that are related to cancer progression, and the overexpression of most MMP genes in cancers is associated with the promotion of invasion, angiogenesis, and immune surveillance avoidance. However, the expression patterns of all MMP genes at the transcriptome and single-cell levels have not been investigated from a pan-cancer perspective. Methods: The Cancer Genome Atlas transcriptome and single-cell sequencing pan-cancer data from the Gene Expression Omnibus were used in the present study to examine the expression patterns of these genes. The MMP-based diagnostic model was constructed using least absolute shrinkage and selection operator regression analysis. Tumors were classified into high and low score MMP groups using ssGSEA. Single-cell data were analyzed using the Seurat R package, and MMP gene expression was validated using quantitative real-time polymerase chain reaction.Results: MMP1, MMP11, and MMP12 expression was upregulated in almost all cancers. MMP19 and MMP27 expression was significantly downregulated in eight to nine cancer types. Correlation analysis results suggested a relationship between MMP expression and tumor immunity and stemness. Single-cell analysis results revealed diverse MMP expression patterns in different cell clusters. Conclusion: The majority of MMPs showed increased expression across cancers, with potential diagnostic value.
Using 17th Century Medication for Modern Diabetes Management: Doctors’ Perceptions of Self-medication Practices – a Qualitative Study
Authors: Puvvada Rahul Krishna , Tang Clarice Y , Thomas Jency , Kay Mitch , Higgs Peter , Jois Markandeya , Ramesh Madhan , Gupta Sabrina
Published: February 2022

Background: Self-medication practices are common among people living with type 2 diabetes. No studies conducted to understand doctors’ perception towards self-medication practices.Aim: To explore doctors’ perceptions and understanding of the self-medication practices of people living with type 2 diabetes in southwestern India. Methods: Semi-structured face-to-face interviews were conducted with doctors experienced in treating patients with type 2 diabetes in Mysuru, India, between July 2019 and January 2020. The interviews explored factors affecting self-medication practices among people living with type 2 diabetes and doctors’ perception on western and traditional medications in the treatment of type 2 diabetes. All the interviews were audio-recorded and thematic analysis was performed inductively. Results: Twenty doctors were interviewed. Doctors reported greater belief in western medications over traditional medications and expressed concern that their patients favoured traditional medications over western. Factors such as social media, accessibility of healthcare facilities and pill burden influenced adherence to western medications. Lack of knowledge about traditional medications and trust in western medications available under government schemes were observed among doctors. Common medication prescription strategies implemented by doctors to overcome challenges of self-medication practices included educating patients on the detrimental effects of self-medication and insisting patients only take western medications when desired blood glucose levels were not observed.Conclusion: The results suggest that multi-prong approach involving all levels of healthcare is needed to overcome the challenges of self-medication practices. Given the contrasting beliefs between doctors and patients, future studies should explore the impact of integrative medicine on health outcomes diabetes people.
Spatial and temporal variation of diversity seaweed (rhodophyceae, chlorophyceae and Phaeophyceae) in the Marchica lagoon (North-East Morocco)
Authors: AKNAF Asmae , AKODAD Mustapha , Layachi Mostafa , Baghour Mourad , OUDRA Brahim
Published: February 2022

The present work is mainly devoted to determine the distribution spatio-temporel seaweeds inventory of the Marchica lagoon. Several sampling campaigns, carried out at the Marchica lagoon (October 2014, January, April, July 2015, and July 2017), had the following objectives: To study the diversity Seaweeds (macroalgal) in different zones of the Marchica lagoon (north-eastern of Morocco), and stadies the spatio-temporal variation of the Marchica algae. The results obtained provided the identification of about 59 algae species inventories, with the dominance of rhodophyceae Ceramieae C. Agardh is a highly diverse group in terms of number of taxa followed by chlorophyceae and fucophyceae. Chlorophyceae make up the majority of the stand during the spring period, but during the summer period the stand experiences a decrease in chlorophyceae and an increase in rhodophyceae. Rhodophyceae (Gracilaria) are the most abundant seaweeds species at the continental edge, near Oued Tirkâa, at the southeast and south of the lagoon. However, chlorophyceae and rhodophyceae (Gracilaria) are located in large quantities near the new pass. While for the fucophyceae, we noticed the new species of C. barbata, which is not found by González and Conde (1991).
Synthesis, Biological Evaluation and Quantum Chemical Studies of novel 3-Acetylpyridin-2(1H)-one Derivative
Authors: Al-Mosauy Hiba H. Ibraheem , Al-Majedy Yasameen Kadhim , Issa Ali Abdullah
Published: February 2022

2, 4-dihydroxybenzaldehyde reacts for ethyl acetoacetate yielded 3-acetyl-7-hydroxy-2H-chromen-2-one (1), which was then cyclized with ethyl acetoacetate in the presence of ammonium acetate to give compound 3-acetyl-4-(4-(dimethylamino) phenyl) -6-(7-hydroxy-2-oxo-2H-chromen-3-yl)pyridin-2(1H)-one (2). Melting point, TLC, FT-IR spectroscopy, and 1H-NMR were used to characterize the newly synthesized compound. Pyridine (2) is a synthetic compound. Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella sp., and Candida albicans were chosen for their antibacterial and antifungal properties. Compounds 2 demonstrated strong antibacterial activity when compared to the regular drug Ampicillin using the diffusion process. Compound 2 showed high antifungal efficacy as compared to the standard medication fluconazole. The results demonstrated that the tested compounds 1 and 2 have substantially stronger antioxidant activity than the well-known antioxidant ascorbic acid. They had a high ability for scavenging DPPH and hydroxyl radicals. Quantum chemical parameters for the highest occupied molecular orbital energy (EHOMO) and the lowest unoccupied molecular orbital energy (ELUMO) were determined and presented.
Tandem Repeats Ubiquitously Flank and Contribute to Translation Initiation Sites.
Authors: Maddi Ali M.A. , Kavousi Kaveh , Arabfard Masoud , Ohadi Hamid , Ohadi Mina
Published: February 2022

Background: While the evolutionary divergence of cis-regulatory sequences impacts translation initiation sites (TISs), the implication of tandem repeats (TRs) in TIS selection remains elusive for the most part. Hence, here we employed the TIS homology concept to study the co-occurrence patterns of all categories of TRs with TISs.Methods: Human, as reference sequence, and 83 other species were selected, and data was extracted on the entire protein-coding genes (n=1,611,368) and transcripts (n=2,730,515) annotated for those species from Ensembl 102. Two different weighing vectors were employed to assign TIS homology, and the results were assessed in 10-fold validation.Results: On average, every TIS was flanked by 1.19 TRs of various categories within the 120 bp upstream sequence of homologous TISs. We detected statistically significant excess of non-homologous TISs co-occurring with human-specific TRs, vice versa. 2,991 human genes had at least one transcript flanked by a human-specific TR in their upstream flanking region, and nervous system development was the top enriched ontology term across those genes. Text mining of a number of the identified genes such as MYH2, TTN, SLC6A8, CACNA1A, and EIF5AL1 yielded predominant expression and functions in the human brain and skeletal muscle. Conclusion: We conclude that TRs are abundant cis elements in the upstream sequences of TISs across species, and there may be a link between all categories of TRs and TIS selection. The potential biological consequences of this link are discussed in human as the reference sequence in this study.
The Association Between Dietary Glycemic Index and Load With Mental Health
Authors: Amirinejad Ali , Davies Ian G. , Mazidi Mohsen , Nadjarzadeh Azadeh , Darand Mina , Mirzaei Masoud , Khayyatzadeh Sayyed Saeid
Published: February 2022

Background: Psychological disorders including depression, anxiety, and stress comprise a huge public health problem. The aim of this cross-sectional study is to assess the relationship between dietary glycemic index (DGI) and glycemic load (DGL) and mental disorders. Method: Participants (n = 10,000) aged 20-69 were randomly selected from 200 clusters in Yazd from the recruitment phase of Yazd Health Study. The dietary intake of study participants was collected by a reliable and validated food frequency questionnaire (FFQ) consisting of 178 food items. DII and DIL were calculated from the FFQ data using previously published reference values. To assess psychological disorders an Iranian validated short version of a self-reported questionnaire (Depression Anxiety Stress Scales 21 [DASS21]) was used.Results: There were no significant associations between DGI and DGL with odds of depression or anxiety in crude and adjusted models. However, individuals in the highest quartiles of DGL had the lowest odds of stress (OR: 0.69; 95% CI: 0.47–1, P-trend = 0.023). This association remained significant after adjustment for potential confounding variables in model I (OR: 0.45; 95% CI: 0.22–0.9, P-trend = 0.023), model II (OR: 0.46; 95% CI: 0.22–0.96, P-trend = 0.039) and model III (OR: 0.46; 95% CI: 0.22–0.96, P-trend = 0.039). Conclusion: In conclusion, consumption of foods with higher GL was associated with lower odds of stress; however, no significant association was found between GI or GL and risk of depression and anxiety. Performing further studies with longitudinal design is suggested to confirm these results.
Heavy Silicone Oil for Rhegmatogenous Retinal Detachment with Inferior Breaks: Long-term Evaluation
Authors: Horozoglu Fatih , Sener Hidayet , Polat Osman Ahmet , Sever Ozkan , Potoglu Busra , Celik Erkan , Turkoglu Elif Betul , Evereklioglu Cem
Published: February 2022

Purpose: To evaluate macular status with optical coherence tomography (OCT) in eyes that underwent pars plana vitrectomy (PPV) and heavy-silicone oil endotamponade for retinal detachment (RD) with inferior breaks.Methods: This study included 20 eyes of 20 patients with a history of retinal detachment surgery for inferior breaks. Oxane HD was used as an intraocular tamponade for all surgeries. Anatomic reattachment, macular status with OCT imaging and any complications in the long-term were evaluated. Results: Mean follow-up time was 19.5 ± 10.5 months (range, 10-59) after removing heavy-silicone oil or epiretinal membrane (ERM) surgery that was performed in some eyes after heavy-silicone oil removal. Primary reattachment was achieved in 90% of eyes and the success rate was 100% with further interventions. Postoperative complications included heavy-silicone oil emulsification, intraocular pressure elevation and epiretinal membrane formation. Conclusion: Eyes treated with PPV and heavy-silicone oil injection for RD with inferior break(s) have a good ellipsoid zone (EZ) continuity in the long-term. ERM formation and removal do not affect EZ.
miRNA targetome associated with early relapse in high grade serous ovarian cancer
Authors: Karatasli Seyhmus , Kalender Mekselina , Ozcan Gulnihal
Published: February 2022

Background: High-grade serous ovarian cancer (HGSOC) is the most lethal subtype of ovarian cancer due to the high rate of early relapse and resistance to chemotherapy. MicroRNAs (miRNAs) control the post-transcriptional expression of a substantial number of coding genes related to ovarian cancer. Therefore, a great interest in the discovery of miRNA-based therapeutics drives many researchers in the field. To identify relevant targets for miRNA-based therapeutics, in this study we analyzed the miRNA targetome associated with early relapse in HGSOC.Methods: Four Gene Expression Omnibus (GEO) datasets were analyzed by GEO2R to find differentially expressed miRNAs (DEMs) in early relapse patients. The miRDB tool was used to predict the gene targets of the DEMs. Functional annotation and cluster analysis was performed on Database for Visualization and Integrated Discovery and Metascape to identify biological processes enriched in the miRNA targetome. To verify the prognostic role of the key miRNA targets, Kaplan-Meier survival analysis was conducted in a validation dataset curated from The Cancer Genome Atlas and GEO datasets on KM-Plotter. A protein-protein interaction network of the prognostic miRNA targets was constructed on STRING. Network analysis was performed on Cytoscape to find the genes with the highest degree and centrality. The interactors and pathways associated with the key miRNA-target genes were searched on inBio Discover.Results: We identified a wide miRNA targetome with fifteen common miRNA targets associated with early relapse in HGSOC. These miRNA targets were enriched in biological processes associated with “transcription from RNA polymerase II promoter”. Further analysis on the validation set verified the prognostic role of thirteen of these targets in HGSOC. The network analysis revealed CWC27, DCUN1D1, MEF2C, and SPOPL as the central miRNA targets associated with early relapse. The primary interactor hubs of these four genes were involved in processes that regulate the synthesis or cleavage of other gene products, further expanding the scope of impact of the miRNA targetome.Conclusions: We believe that the four miRNA targets we identified in this study may be potential targets of miRNA-based therapeutics to prevent early relapse in HGSOC.
Schistosomes from the Persian Gulf: phylogenetic relationships, host associations and life-cycle elucidation of Ornithobilharzia canaliculata (Rudolphi, 1819) Odhner, 1912
Authors: Khosravi Maral , Thieltges David W. , Shamseddin Jebreil , Georgieva Simona
Published: February 2022

Background: Avian schistosomes comprise a diverse and widespread group of trematodes known for their surprising ability to switch into new hosts and habitats. Their cercariae are the causative agents of the waterborne allergic disease cercarial dermatitis. There are 13 recognised genera of avian schistosomes with majority of the extant species with freshwater-based life-cycles. Despite the considerable research attention on avian schistosomes much less it is known about the diversity, geographical range and host associations of the marine representatives. Here, we provide novel data on the species diversity and host-parasite relationships of the marine schistosomes in respect to their intermediate gastropod host from the Persian Gulf. Methods: A total of 1,745 horn snails of Pirenella cingulata (Gmelin), were examined during a survey from December 2019 to February 2020 from eight distinct locations along the coast of Iran. Partial sequences of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and the nuclear 28S rRNA gene were generated for the schistosome isolates recovered and used for molecular identification and phylogenetic reconstruction. Results: Our molecular analyses inferred from both molecular markers revealed presence of two schistosome species, Ornithobilharzia canaliculata (Rudolphi, 1819) Odhner, 1912 and a putative new species of Austrobilharzia Johnston, 1917. Molecular elucidation of the life-cycle of O. canaliculata was achieved for the first time via matching novel and published sequence data from adult and larval stages. This is the first record of Ornithobilharzia from the Persian Gulf and globally the first record of this genus in a potamidid snail host.Conclusions: The present study provides new host and distribution records for major etiological agents of cercarial dermatitis and contributes important information on host-parasite relationships. Our study further highlights the importance of the molecular systematics in the assessment of schistosome diversity and calls for further surveys in order to reach a better understanding of the schistosome diversity and patterns of relationships among them, host associations, transmission strategies and distribution coverage.
Targeting the gut microbiota with inulin: a novel approach for the management of irradiation- induced colonic fibrosis
Authors: Ji Kaihua , Zhang Manman , Du Liqing , Liu Yang , Xu Chang , He Ningning , Wang Qin , Wang Jinhan , Gu Yeqing , Song Huijuan , Sun Xiaohui , Wang Yan , Liu Qiang
Published: February 2022

Background
Radiation therapy used to treat pelvic and abdominal tumors can cause acute or chronic radiation enteropathy. Chronic radiation intestinal fibrosis is one of the most common causes of gastrointestinal complaints. Here, we aimed to clarify that the supplement of dietary fiber inulin can alleviate chronic radiation-induced intestinal fibrosis by altering the gut microbiota, and to elucidate the mechanism.
Results
Inulin supplements have been shown to elevate the abundances of bacterial that produce short-chain fatty acids (SCFAs) and increased fecal concentrations of microbially derived SCFAs. In validation experiment, transplantation of inulin-derived gut microbiota and metabolite alleviated colonic fibrosis in a mouse model of chronic radiation enteropathy. Treatment with inulin-derived gut microbiota metabolites significantly reduced the expression of fibrosis-related genes and collagen synthesis-related genes in the mouse embryonic fibroblast cell line NIH/3T3. In NIH/3T3 cell lines, the use of inulin-derived metabolites also inhibited the expression of genes related to the extracellular matrix synthesis pathway.
Conclusions
These evidences highlight that inulin might be employed as a safe and effective supplement to fight against chronic radiation intestinal fibrosis. Our finding also provides a novel insight into targeting changes in gut microbiota to treat radiation enteropathy.
Living with dementia during the COVID-19 pandemic: insights into identity from the IDEAL cohort
Authors: Stapley Sally , Pentecost Claire , Collins Rachel , Quinn Catherine , Dawson Eleanor , Morris Robin , Sabatini Serena , Thom Jeanette , Clare Linda
Published: February 2022

The continuing COVID-19 pandemic and social restrictions have impacted on the cognitive decline and mental health of people with dementia. Social isolation and loss of activities due to social restrictions may also have implications as to sense of identity for people with dementia. As part of the INCLUDE component of the IDEAL cohort study, the overall aim of this subtle realist qualitative study was to explore the perspectives of people with dementia on living through the COVID-19 pandemic in England and Wales during the post-vaccine time period; also with focus on the study findings in relation to understandings of identity in dementia. Seven people with mild-to-moderate dementia were interviewed, and themes derived using framework analysis. Themes suggest interviewees’ stoic acceptance of the pandemic and social restrictions but also fear of decline related to the temporality of their condition as well as loss of self-confidence to re-engage with the world, and loss of social connections. Under threat due to lack of access to dementia groups, the importance of a shared, social identity, particularly for people with young-onset dementia, was apparent. With valued activities also prevented or reinvented during the pandemic, the relevance of occupation for identity is discussed. Although under continued pressure, services must consider how people with dementia and their family caregivers can best be supported during the ongoing pandemic.
Importance of Green Areas for Insectivorous Bat Activity
Authors: Almeida Marcio Henrique , Mischiatti Francyne Lyrio , Tokumaru Rosana Suemi , Ferreira José Henrique Benedetti Piccoli , Ditchfield Albert David
Published: February 2022

The impact of urbanization might differ between insectivorous bats that forage in open space as opposed to edge space, with the latter usually persisting only in well preserved areas, such as parks and natural reserves. We investigated the influence of vegetation patches of different sizes on the activity of these two groups of insectivorous bat in the urban area of the Metropolitan region of Vitória, Espírito Santo State, Brazil. For this purpose, we monitored bat activity with an ultrasound detector for a total of two years in three habitats: large-green areas (> 30ha), small-green areas (< 5 ha) and non-green areas. Large-green areas showed the greatest bat activity followed by small-green areas and non-green areas. Although both groups of bats showed an increase in activity in the green areas compared to the non-green areas, this effect was higher for edge-space foragers than for open-space foragers in the large green-areas, whereas in the small green areas, the increment in activity did not differ between them. We also present a list of eight species we identified in the study area. Two of the species represent the first record for the region: Promops centralis and Peropteryx trinitatis. We conclude that in the Metropolitan Region of Vitória, even small parks are important for bat fauna conservation and, despite being more adapted to urban environments, even open-space foraging bats can benefit from them.
Evaluasi Usability Aplikasi EDMODO dengan SUS dan Thematic Analysis
Authors: Sutoyo Mochammad Arief Hermawan , Rahayu Puji
Published: February 2022

The Covid pandemic that occurred in 2020 prompted the Indonesian government to issue policies related to distance education (PJJ), to avoid the spread of disease. This sudden appeal caused tertiary institutions and students who were not ready to be ready and accustomed to the situation. To do PJJ at X University, which is located in Jambi province, use EDMODO as an application to do PJJ. The use of EDMODO as a PJJ media has been going on for almost 2 semesters, but the effectiveness of teaching via EDMODO has not been studied for its success, so an analysis is needed related to the application of EDMODO as a PJJ application. The author uses a system usability scale to analyze the educational usability level of this application. From the calculation results, the average value of SUS is 71,2. However, there is a possibility of decreasing educational usability in this application. So, it is recommended that this application be developed again.
Analisis Tingkat Kesiapan Pengguna Sistem Informasi Koreksi Essay Otomatis Berbasis Web Menggunakan Model Technology Readiness Index (TRI)
Authors: Adhitama Rifki , Wijayanto Aditya , Kusumawardani Dwi Mustika
Published: February 2022

During the pandemic, the learning model directly impacts both students and teachers, especially in evaluating and correcting assignments to measure student learning. Evaluation and correction of the learning process at both the high school and high school and university levels are generally carried out multiple-choice examinations during this pandemic. Many tools can be used to carry out multiple-choice assessments. The essay assessment is usually done manually and takes a long time because the lecturer has to make corrections one by one. On the other hand, information retrieval is a concept that can be used to build an automatic essay correction information system so that the correction of essay questions can be done quickly and efficiently, as in multiple-choice works. The automatic essay correction information system is a relatively new technology, especially for its plural use in this pandemic. A new technology that will be applied in a plural manner requires a measurement. One of the measurements that can be used is the Technology Readiness Index (TRI). TRI is used because it can measure the readiness and tendency of users to implement an information system. The case study in this research was conducted at the Faculty of Informatics (FIF) Telkom Institute of Technology Purwokerto (ITTP). The TRI measurement of the automatic essay correction information system carried out at FIF produces a TRI of 3.27. This value is between 2.90 and 3.51 (2.90 ≤ TRI ≤ 3.51). Consisted of an optimism value of 1.01, and innovativeness value of 0.52, a discomfort value of 0.55, and an insecurity value of 1.19.
Implementasi forecastHybrid Package menggunakan R Studio Cloud untuk Prediksi Pertumbuhan Dana Pihak Ketiga dan Pembiayaan Pada Bank Muamalat Indonesia
Authors: Astuti Niken Probondani , Bakri Rizal
Published: February 2022

This study aims to find out how to forecast the growth performance of third party funds (TPF) and financing which is measured on a quarterly by applied the hybrid method with R Studio Cloud using ‘forecastHybrid’ package. This prediction is expected to provide information and data on the growth of third party fund and financing for Bank Muamalat which is experiencing problems of lack of capital and non-performing funds (NPF). Forecasting with Hybrid methods combines ARIMA auto forecasting methods, exponential smoothing forecasting methods, theta forecasting methods, neural network forecasting methods, seasonal and trend decomposition forecasting methods, and TBATS forecasting methods. The forecast results show that the Hybrid method is able to provide information as a decision-making material for Bank Muamalat
Elazığ Koşullarında İskenderiye Üçgülü ile İtalyan Çimi Karışım Oranlarının Verim ve Kalite Üzerine Etkileri
Authors: KARADENİZ Mustafa , KÖKTEN Kağan
Published: February 2022

Bu çalışma farklı familyalara ait yem bitkilerinin farklı karışım oranları (İskenderiye üçgülü:İtalyan çimi; %100:0, %80:20, %60:40, %40:60, %20:80 ve %0:100) ile ot kalitesine ve verimine etkisinin belirlenmesi amacı ile yürütülmüştür. Çalışmada, materyal olarak Doğu Akdeniz Tarımsal Araştırma Enstitüsüne ait İskenderiye üçgülü (Trifolium alexandrinum L.)’nün Derya çeşidi ile Ege Tarımsal Araştırma Enstitüsünden sağlanan İtalyan çimi (Lolium multiflorum Lam.)’nin Elif çeşidinde bitki boyu, yeşil ot ve kuru ot verimleri, yeşil otta ve kuru otta üçgül oranları, ham protein oranı ve verimi, asit deterjanda çözünmeyen lif, nötral deterjanda çözünmeyen lif, sindirilebilir kuru madde, kuru madde tüketimi oranları ve nispi yem değeri gibi karakterler araştırılmıştır. Deneme, 4 tekrarlamalı olarak tesadüf blokları deneme desenine göre 2020 yılının yaz döneminde Elazığ il merkezine ait Bahçekapı köyünde yürütülmüştür. Çalışma bulgularına göre; karışımların ortalama yeşil ot verimi 3784.9 kg da-1, kuru ot verimi 1210.8 kg da-1, ham protein verimi 146.6 kg da-1 olarak tespit edilmiştir. Karışımların ham protein, asit deterjanda çözünmeyen lif (ADF), nötral deterjanda çözünmeyen lif (NDF), sindirilebilir kuru madde (SKM), kuru madde tüketimi (KMT) oranları ve nispi yem değeri (NYD) sırasıyla %12.04, %35.7, %50.9, %61.0, %2.36 ve 112.15 olarak belirlenmiştir. Çalışma sonucunda; Elazığ ekolojik koşullarında kuru ot, yeşil ot, ham protein oranı ve verimi bakımından en uygun karışım oranlarının %80 İskenderiye üçgülü + %20 İtalyan çimi karışımı ile %60 İskenderiye üçgülü + %40 İtalyan çimi karışımı olduğu belirlenmiştir. Karışımlarda İskenderiye üçgülünün daha yoğun olduğu parsellerde kuru ot, yeşil ot ve ham protein verimleri ile ham protein oranlarının daha yüksek çıktığı görülmüştür.
Morphological and Molecular Identification of Biofilm Forming Fungi from Fish Farms and Fish Benches in Aydın Province
Authors: TÖRÜN Bahadır , BIYIK Hacı Halil , POYRAZOĞLU Esin
Published: February 2022

Biofilm formation is one of the major problems in many industries. The marine environment is rich in nutrients for microbial growth. It also makes it easier for microorganisms to form biofilms. This study aims to identify biofilm-forming fungi in the marine environment and assess their ability to form biofilm. We identified biofilm-forming fungi species using morphological and molecular methods. ITS regions were used for molecular identification. The qualitative assessment of biofilms was carried out using the Petri dish method, and quantitative measurements of biofilms were carried out using the microplate method. We identified 69 isolates; 37 were yeast, and 32 of them were fungi. Only ten of them were found to have biofilm. Most of them were adherents, and only two of them were strong adherents. Biofilms can have positive or negative effects on fish health. Identifying biofilm-forming agents will help us identify the nature of the effect. Microorganisms that have positive effects can be used as biocontrol agents.
2-kloro-1-(6-floro-3,4-dihidro-2H-kromen-2yl)ethanon Yapısının Yoğunluk Fonksiyonel Kuramı İle Kimyasal Aktivite Hesaplamaları
Authors: DEMİRCİOĞLU Zeynep , UZUN Serap
Published: February 2022

Bu çalışmada, sentezi yapılmış ve X-ışını kırınımı yöntemi ile yapısı aydınlatılmış 2-kloro-1-(6-floro-3,4-dihidro-2H-kromen-2yl) ethanon molekülünün kimyasal aktivitesi, ikinci dereceden lineer olmayan optik özellikleri ve DNA bazları ile etkileşimi üzerine kuramsal çalışmalar yapılmıştır. Kuramsal yöntem olarak, deneysel çalışmalara yakın ve anlamlı değerler vermesi ayrıca hesapsal maliyeti nedeniyle Yoğunluk Fonksiyonel Kuramı (YFK) seçildi. Çalışılan molekülün kararlı moleküler geometrisi optimizasyon yapılarak elde edildi. Tüm kuramsal hesaplamalarda YFK/B3LYP/6-311++G(d,p) baz seti kullanıldı. Optimize edilmiş molekülün geometrik parametre değerlerinin deneysel verilerle uyumlu olduğu görüldü. Frekans hesaplamaları sonucunda sanal frekans verisinin gözlenmemesi de yapının başarılı olarak optimize edildiğini destekledi. Böylece optimize yapı üzerinden elde edilen diğer özellikler hesaplanarak yorumlandı. Molekülün kimyasal aktivitesinin hesaplanmasında sınır moleküler orbital (HOMO, LUMO) enerjileri kullanılarak sertlik, yumuşaklık ve diğer kimyasal aktivite parametreleri elde edildi. Moleküler elektrostatik potansiyel (MEP), yük popülasyon ve Fukui fonsiyon analizleri ile yapının hangi bölgelerde kimyasal etkileşime yatkın olduğu belirlendi. Bunların yanı sıra Hirshfeld yüzey analizi ile moleküler etkileşimler, Hirshfeld yüzey haritaları, atomların birbirleriyle etkileşim yüzdeleri 2 boyutlu-parmak izi tayini ile incelendi.
Association of DRD2 Gene C957T Polymorphism with Stuttering in Turkish Population
Authors: POLAT Fikriye , AYDİN Ayşe , YÜKSEL Burcu
Published: February 2022

This study aims to evaluate the association of DRD2 gene C957T polymorphism with stuttering within Turkish children who stutter. The sample of the study included 121 children between the ages of 5-16, 44 children with stuttering and 77 typically developing children. The genomic DNA’s were extracted from the saliva of the individuals. The genotyping of DRD2 C957T was carried out using polymerase chain reaction-restriction fragment length polymorphism. The relationship between genotypes and stuttering was examined through logistic regression analysis. In the study, it was determined that distributions of allele frequencies and the DRD2 gene C957T polymorphism were not significantly different from the control group (OR 0.762; CI 0.458-1.267, p=0.304). The genotype distributions of the DRD2 gene were estimated for CT (OR 1.103; CI 0.443-2.743, p=0.833) and TT (OR 0.868; CI 0.306-2.461; P=0.791). The genotype distributions of DRD2 C957T polymorphism were not statistically significant for additive, dominant, recessive, and codominant models between study groups. As a result, the polymorphic feature of the alleles and genotypes for the DRD2 gene C957T in Turkish children who stutter were analyzed, and it was detected that the differences between CWS and CWNS groups were not significant.Keywords: Stuttering, DRD2, rs6277, Turkish population
Midyat /Mardin Yöresinde Yetiştiriciliği Yapılan Üzüm Çeşitlerinin Etkili Sıcaklık Toplamı İhtiyaçlarının Tespiti
Authors: ÜNAL Mehmet Settar , SEZGİN Hasan
Published: February 2022

Bu araştırma; 2019 ve 2020 yıllarında, Mardin ili Midyat yöresinde yetiştirilen bazı yerel üzüm çeşitleri üzerinde yürütülmüştür. Araştırmada çeşitlerin bazı karakterleri, gözlerin sürmesi, çiçek açma, olgunluk başlangıcı ve olum dönemleri, vegetasyon periyodu ve aktif sıcaklık toplamı verileri incelenmiştir. Araştırma sonunda sürme-olum dönemleri arasında hesap edilen aktif sıcaklık toplamlarının 1275 gd (Hazirani)-2488 gd (Mazrone), gelişme sürelerinin ise 104 gün (Hazirani)-175 gün (Mazrone) arasında değiştiği tespit edilmiştir. EST (Etkili Sıcaklık Toplamı) değerleri ve gelişme süreleri; yıl, iklim, arazinin konumu ve toprak yapısı, çeşit özelliği ve hatta bakım işlemlerine göre farklılık göstermiştir. Mardin ilinde yetiştirilebilecek ticari değeri yüksek üzüm çeşitlerini tavsiye ederken araştırma sonucunda belirlenen EST değerlerinin göz önünde bulundurulması gerektiği ve “Sıcak İklim” sınıfına dahil olan Midyat yöresinin iklim yapısının, piyasada sevilen ve tutulan son turfanda sofralık ve kurutmaya uygun üzümler için oldukça elverişli olabileceği belirlenmiştir.
Numerical Method for Approximate Solution of Fisher's Equation
Authors: KARTA Melike
Published: February 2022

In this paper, Fisher's reaction diffusion equation has been solved numerically by Strang splitting technique depending on collocation method with cubic B-spline. For our purpose, the initial and boundary value problem consisting of Fisher's equation is split into two sub-problems to be one linear and the other nonlinear such that each one contains the derivative in terms of time. Then, the whole problem is reduced to the algebraic equation system using finite element collocation method combined with the cubic B-spline for spatial discretization and the convenient classical finite difference approaches for time discretization. The effective and efficiency of the newly given method have been shown on the four examples. In addition, the newly obtained numerical results are shown in formats graphical profiles and tables to compare with studies available in the literature.
Seri Robot Manipülatöründe Ters Kinematik Problemi Çözmek İçin Kaotik Tabanlı Çiçek Tozlaşma Algoritmasının Uygulanması
Authors: GARİP Zeynep
Published: February 2022

Ters kinematik problemlerinin çözümü, seri robot manipülatörlerinin temel problemlerinden biridir. Bu çalışmada, 7 serbestlik dereceli bir seri manipülatörün ters kinematik problemini çözme karmaşıklığını en aza indirmek için kaotik tabanlı bir algoritma geliştirilmiştir. Henon kaotik harita ile modifiye edilen çiçek tozlaşma algoritması kullanılarak orijinal algoritmanın global ve lokal arama özelliklerinin etkinliği arttırılması amaçlanmıştır. Simülasyon çalışmaları için, modifiye edilmiş algoritmaların performansını doğrulamak için metre cinsinden P1[−25 100 50], P2 [50 − 25 75] ve P3 [50 − 25 75] olmak üzere üç farklı istenen konum vektörü seçilmiştir. Ayrıca bu algoritmalar son efektörün konum hatası ve çözüm süresine göre karşılaştırılmıştır. Simülasyon sonuçları, seri robot manipülatörünün ters kinematik çözümleri için kaotik tabanlı algoritmaların etkin bir şekilde kullanılabileceğini göstermiştir.
Analysis of the evolution pattern and causes of downstream gigantic hydraulic projects
Authors: Liu Linshuang , Luo Wenguang , Zhang Liguo , Ming Bo , Li Ming , Jiang Jing
Published: February 2022

The Jingjiang reach, located in the middle Yangtze River, downstream of the Three Gorges Reservoir (TGR), is a typical curved reach. After TGR impoundment, the evolution behaviors of the Jingjiang reach changed, mainly because one or more original factors, including geological conditions, existing projects, bending radius, upper reaches' regimes, and incoming water and sediment changed. In this paper, these influencing factors were investigated by using the measured data and the mathematical models that were proposed by the authors in a previous paper, and consequently, the evolution laws of the curved reach were analyzed. The results showed that the existing river nodes reduced the influence of the upstream river regime on the evolution of curve reaches and also slowed the speed of convex bank scouring and concave bank depositing. Constructed projects could reduce sediment transport intensity from the concave bank to the convex bank. The decrease in incoming sediment after TGR impoundment was beneficial to convex bank scouring. The increase in median water period duration was favorable for convex bank scouring and concave bank depositing. Both convex bank and concave bank were scoured when the incoming sediment concentration decreased sharply. The sediment concentration of suspended load would stabilize near the saturation point, and the riverbed would be scoured when there is sediment concentration under the saturation point, while the riverbed would be deposited when the sediment concentration reaches the saturation point.
Extraction and analysis of surface lake flow direction in Poyang Lake based on texture enhancement and Hough transform
Authors: Kuang RunYuan , Qiu Yun , Peng WenJie
Published: February 2022

Lake flow is one of the common hydrological phenomena in nature. The water exchange of lakes and the circulation of natural water resources are realized by the water movement caused by various factors. Lake current is of great significance in the hydrological and ecological environment and it is one of the focuses of scholars’ research. This paper takes Poyang Lake as the research area, and uses three texture enhancement methods of Laws, Gabor, and LBP operators to enhance the texture features of images based on multi-source remote sensing data, and uses the Hough transform to extract the flow direction of the Poyang Lake area. The results show that the three texture enhancement methods combined with Hough transform can extract the flow direction, but the Gabor filter has the best flow direction effect and the highest extraction accuracy. Gabor filter is the most adaptable for texture enhancement of images with different resolutions.
Quality awareness of tap drinking water among Bangkok city residents and implications for sustainable supply management
Authors: Tiyanun Ekasit , Kooltheat Nateelak , Katzenmeier Gerd , Srisuphanunt Mayuna
Published: February 2022

Although tap water in Bangkok has met international standards, some consumers do not trust that it is safe to drink. The demand for bottled water is still increasing. This may result in infrastructure investments and the production of waste. This study aimed to explore factors that influence the acceptance of drinkable tap water among Bangkok residents. Data for this cross-sectional study were collected via an interview of 374 participants using a structured questionnaire. There was a significant prevalence (51.87%) of the acceptance of drinkable tap water among Bangkok residents. Among them, 82.99% selected tap water to drink and 9.79% drank water directly from the tap. Factors that affected the acceptance of drinkable tap water were occupation, monthly income, campaign perception, personal belief, unacceptable sensory appearance, risk perception, knowledge, and attitude. This study found that drinking water selection was not associated with self-reported diarrhea. While we recognize that the cross-sectional study has some limitations, our data may provide additional insight into factors which affect consumers' behavior and may offer several benefits for water suppliers and public health decision-makers. This would eventually increase public awareness for economic benefits associated with the use of tap water and finally would reduce pollution by plastic waste.
Delineating the groundwater potential zones in Bangladesh
Authors: Sarkar Showmitra Kumar , Esraz-Ul-Zannat Md. , Das Palash Chandra , Ekram Khondaker Mohammed Mohiuddin
Published: February 2022

The objective of this research is to identify groundwater potential zones for Bangladesh. Fourteen influential factors associated with topography, geology and meteorological concerns were applied for this study. Weights for factors and sub-factors within a factor were calculated based on pairwise comparisons. The groundwater potential zones were delineated through GIS-based weighted overlays of factor maps. According to the pairwise comparison, the consistency ratios for factors and sub-factors were within the allowable range (i.e., less than 0.10). General soil type (eigenvalue 0.17), geology (eigenvalue 0.16), and geomorphology (eigenvalue 0.15) were the most important factors in determining groundwater potential zoning. The groundwater potential index has maximum and minimum values of 45.99 and 10.34, respectively. According to the groundwater potential map, relatively higher groundwater potential zones were found in the southern parts of Bangladesh and along major rivers. The study's findings will be useful to government authorities in making evidence-based decisions about national water policy and planning.
Metallic Nanoparticles: A New Frontier in the Fight Against Leishmaniasis
Authors: Guerra Rhanoica Oliveira , do Carmo Neto José Rodrigues , de Albuquerque Martins Tarcísio , Farnesi de-Assunção Thaís Soares , Junior Virmondes Rodrigues , de Oliveira Carlo José Freire , Silva Anielle Christine Almeida , da Silva Marcos Vinicius
Published: February 2022

Leishmaniasis, a cutaneous, mucocutaneous, or visceral parasitic disease caused by the protozoa of the genus Leishmania, is responsible for approximately 20-40 thousand deaths annually, with Brazil, India, and certain countries in Africa being the most affected. In addition to the parasite’s ability to evade the host’s immune system, the incidence of vectors, genetics of different hosts, and several deaths are attributed to the limited conventional treatments that have high toxicity, low effectiveness, and prolonged therapeutic regimens. Thus, the development of new alternative therapeutic strategies remains warranted. Metallic nanoparticles, such as gold, silver, zinc oxide, and titanium dioxide, have shown promising therapeutic tools since they are easily prepared and chemically modified, have a broad spectrum of action and low toxicity, and can generate reactive oxygen species and other immune responses. This review explores the progress of the use of metallic nanoparticles as new tools in the treatment of leishmaniasis and discusses the gaps in knowledge hindering the development of a safe and effective therapeutic intervention against these infections.