bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between IL1A and IL1B polymorphisms and primary open angle glaucoma in a Brazilian population
Authors: Oliveira Mariana B , de Vasconcellos José Paulo C , Ananina Galina , Costa Vital P , de Melo Mônica B
Published: November 2018

The aim of this study was to investigate the association of five polymorphisms in the IL1A and IL1B genes in Brazilian patients with primary open angle glaucoma (POAG). A case–control study, including 214 unrelated POAG patients and 187 healthy individuals, was conducted to evaluate the frequency of polymorphisms in the IL1A and IL1B genes. Ophthalmic evaluation was performed and genomic DNA was obtained from all participants. Five single nucleotide polymorphisms (SNPs): IL1A (–889C/T: rs1800587:C > T, +4845G/T:rs17561G>T) and IL1B (–31C/T:rs1143627:T > C, –511C/T:rs16944C>T and +3954C/T:rs1143634:C > T) were genotyped through direct sequencing. The association of individual SNPs was tested using logistic regression. There was an association between the –31C/T and –511 C/T polymorphisms in the IL1B gene with POAG (p = 0.002 and p = 0.009, respectively). High linkage disequilibrium was observed between the –31C/T and –511C/T polymorphisms. The statistical analysis showed that the T/C haplotype (–31/–511) in the IL1B gene is more frequent in controls (p = 0.011) and the C/T haplotype (–31/–511) is more common in POAG patients (p = 0.018). Among POAG cases, the genotypic distribution of the –31C/T and –511 C/T SNPs was significantly different in patients who underwent anti-glaucomatous surgery compared to patients without surgery (p = 0.016 and 0.023, respectively). There was no statistically significant difference for the remaining SNPs between POAG patients and controls. In conclusion, the C allele of the –31C/T and the T allele of the –511C/T polymorphisms in the IL1B gene may represent a “risk haplotype” for the development of POAG in Brazilian individuals. Further studies with larger cohorts of patients are necessary to substantiate these findings.
The Measure of Quality of the Environments’ Turkish Validity and Reliability
Authors: Akyurek Gokcen , Bumin Gonca
Published: November 2018

The aim of this study was to translate the Measure of Quality of the Environment–Short Form (MQE-SF) into Turkish language and to evaluate the validity and reliability. The MQE-SF was culturally adapted via an internationally suggested method. A total of 185 volunteers with disabilities (age range = 18-55 y/o, 107 males; 78 females) from the Disabled People Association of Turkey completed the MQE-SF. To evaluate the MQE-SF’s criterion/concurrent validity, the Craig Hospital Inventory of Environmental Factors (CHIEF) was also administered. Test–retest reliability was evaluated by administering MQE-SF to 85 participants a second time within 14 days of initial administration. The alpha coefficient measuring the internal consistency of the questionnaire were .84 and .83. The criterion-related validity was moderate between the MQE-SF Barriers and the CHIEF ( r = –.46, p < .05). The questionnaire was moderately reliable in terms of the test–retest reliability ( r = .69, .70 p < .05). The Turkish adaptation of the MQE-SF had good internal consistency and moderate criterion-related validity as well as test–retest reliability for people with disabilities.
Military Service Member Perspectives About Occupational Therapy Treatment in a Military Concussion Clinic
Authors: Cogan Alison M. , Huang Janice , Philip Joyce
Published: November 2018

The purpose of this study is to describe important features of occupational therapy practice for treatment of military service members with chronic symptoms and a history of mild traumatic brain injury (mTBI) in a military concussion care clinic from service members’ perspectives with support from occupational therapy practitioners. Two series of focus groups were conducted with service members with chronic mTBI-related symptoms ( n = 6) and practitioners ( n = 5). Data were analyzed concurrently with collection. We identified five main themes: therapeutic relationship, consistent inclusion of family members, combat versus noncombat injuries, loss of military identity, and assessment against population norms. The findings of this study suggest that service members’ evaluations of occupational therapy are based on the overall experience of the encounter, centered by the therapeutic relationship, rather than specific intervention strategies or technology.
Human Factors–Based Mobile Application Design for Global Health
Authors: Schwab Tyson , Langell John
Published: November 2018

Background. The rapid adoption of smartphones and software applications (apps) has become prevalent worldwide, making these technologies nearly universally available. Low-cost mobile health (M-health) platforms are being rapidly adopted in both developed and emerging markets and have transformed the health care delivery landscape. Human factors optimization is critical to the safe and sustainable adoption of M-health solutions. The overall goal of engaging human factors requirements in the software app design process is to decrease patient safety risks while increasing usability and productivity for the end user. Methods. An extensive review of the literature was conducted using PubMed and Google search engines to identify best approaches to M-health software design based on human factors and user-centered design to optimize the usability, safety, and efficacy of M-health apps. Extracted data were used to create a health care app development algorithm. Results. A best practice algorithm for the design of mobile apps for global health care, based on the extracted data, was developed. The approach is based on an iterative 4-stage process that incorporates human factors and user-centered design processes. This process helps optimize the development of safe and effective mobile apps for use in global health care delivery and disease prevention. Conclusion. Mobile technologies designed for developing regions offer a potential solution to provide effective, low-cost health care. Applying human factors design principles to global health care app development helps ensure the delivery of safe and effective technologies tailored to the end-users requirements.
Smoking Increases Postoperative Complications After Distal Radius Fracture Fixation: A Review of 417 Patients From a Level 1 Trauma Center
Authors: Hess Daniel E. , Carstensen S. Evan , Moore Spencer , Dacus A. Rashard
Published: November 2018

Background: Unstable distal radius fractures that undergo surgical stabilization have varying complication rates in the literature. Smoking is known to affect bone healing and implant fixation rates but has never been definitively shown to affect postoperative outcomes of surgically managed distal radius fractures. Methods: A retrospective review was performed of patients with surgically treated distal radius fractures at a Level 1 Trauma Center who had at least 6 weeks of follow-up over a 5-year period. Charts were reviewed for basic demographic information, comorbidities, details about the operative procedure, and early complications. Notable physical examination findings were noted, such as wrist stiffness and distal radius tenderness to palpation. Statistical analysis was performed to compare the smoking and nonsmoking groups. To control for confounding differences, a hierarchical multivariable regression analysis was performed. Results: Four hundred seventeen patients were included in the study, and 24.6% were current smokers at the time of surgery. The overall complication rate for smokers was 9.8% compared with 5.6% in nonsmokers. The smoking cohort showed significantly higher rates of hardware removal, nonunion, revision procedures, wrist stiffness, and distal radius tenderness. When controlling for the confounding variables of diabetes and obesity, smokers still had significantly higher rates of the same complications. Conclusion: Patients who smoke have a statistically significant higher rate of postoperative distal radius tenderness, wrist stiffness, nonunion, hardware removal, and revision procedures compared with those who do not smoke in a review of 417 total patients undergoing surgical fixation for distal radius fractures.
Phone-based intervention for blood pressure control among Ghanaian stroke survivors: A pilot randomized controlled trial
Authors: Sarfo Fred Stephen , Treiber Frank , Gebregziabher Mulugeta , Adamu Sheila , Nichols Michelle , Singh Arti , Obese Vida , Sarfo-Kantanka Osei , Sakyi Asumadu , Adu-Darko Nyantakyi , Tagge Raelle , Agyei-Frimpong Marian , Kwarteng Naomi , Badu Elizabeth , Mensah Nathaniel , Ampofo Michael , Jenkins Carolyn , Ovbiagele Bruce ,   on behalf of PINGS Team
Published: November 2018

Background

The potential of mobile-health (mHealth) technology for the management of hypertension among stroke survivors in Africa remains unexplored. We assessed whether an mHealth technology-enabled, nurse-guided intervention initiated among stroke patients within one month of symptom onset is effective in improving their blood pressure (BP) control.

Methods

A two-arm pilot cluster randomized controlled trial involving 60 stroke survivors, ≥18 years, with BP ≥140/90 mmHg at screening/enrollment visit at a medical center in Ghana. Participants in the intervention arm (n = 30) received a Blue-toothed BP device and smartphone with an App for monitoring BP measurements and medication intake under nurse guidance for three months after which intervention was withdrawn. Control arm (n = 30) received usual care. Primary outcome measure was proportion with clinic BP < 140/90 mmHg at month 9; secondary outcomes included medication adherence.

Findings

Mean ± SD age was 55 ± 13 years, 65% males. Two participants on intervention and three in control group were lost to follow-up. At month 9, proportion on the intervention versus controls with BP < 140/90 mmHg was 14/30 (46.7%) versus 12/30 (40.0%), p = 0.79 by intention-to-treat; systolic BP < 140 mmHg was 22/30 (73.3%) versus 13/30 (43.3%), p = 0.035. Mean ± SD medication possession ratio was 0.95 ± 0.16 on intervention versus 0.98 ± 0.24 in the control arm, p = 0.56.

Interpretation

We demonstrate feasibility and signal of improvement in BP control among stroke survivors in a resource-limited setting via an mHealth intervention. Larger scale studies are warranted.

Trial registration

NCT02568137. Registered on 13 July 2015 at ClinicalTrials.gov.
Post-Occupancy Evaluation of a Crisis Shelter Garden and Application of Findings Through the Use of a Participatory Design Process
Authors: Lygum Victoria L. , Poulsen Dorthe V. , Djernis Dorthe , Djernis Hanne G. , Sidenius Ulrik , Stigsdotter Ulrika K.
Published: November 2018

Objective:

This study concerned optimization of an evidence-based crisis shelter garden as a setting for everyday activities and nature-based therapy. The study hereby tested the design guidelines that the garden is based on.

Background:

Design guidelines for gardens intended to support health are becoming increasingly specialized, targeting different user groups. This study contributes to the knowledge concerning health-supporting garden design at crisis shelters for women and children who are exposed to domestic violence.

Method:

The study included a post-occupancy evaluation (POE) consisting of landscape analyses, observation of physical traces, and interviews as well as a subsequent participatory design process.

Results:

The landscape analyses and the observation of physical traces indicated a minimal level of maintenance and recurrent use being limited to a few areas of the garden. The interviews added nuance and new issues to these results, resulting in the following themes: maintenance, accessibility, safety, therapeutic setting and free space, many ways to play, and social and private spheres. The participatory design process led to an optimization of the garden, including changes to its physical design related to making the garden safer, positively distractive, and more versatile in terms of activities. Improvements were also made regarding policy for use, maintenance, and informing users.

Conclusion:

The design guidelines were tested, and the evidence was strengthened, adding nuance and new issues to consider during further development of the guidelines. Both the POE and the participatory design process were confirmed as crucial aspects of evidence-based health design.
Renal cell carcinoma in Ireland: rising mortality and survival
Authors: Yap Lee Chien , Leonard Frank , Cullen Ivor , Daly Padraig
Published: November 2018

Objective:

The objective of this study was to evaluate the rising trend in the incidence and mortality of renal cell carcinoma in Ireland.

Methods:

Data from the National Cancer Registry of Ireland on primary adenocarcinomas of the kidney from 2003 to 2013 were evaluated. Statistical analysis was performed on the data using IBM SPSS statistics V24 software package and Microsoft Excel Software.

Results:

There were 3801 cases of adenocarcinoma of the kidney with 29% of tumours (n=1103) being found incidentally. The age-adjusted incidence rate of renal cell carcinoma in 2003 was 4.66 per 100,000 women and 8.78 per 100,000 men. These figures have risen to 5.78 and 13.14 in 2013, respectively. There was an annual percentage change of +2.2% for women and +4.1% for men from the years 2003 to 2013. For both sexes the age-standardised all-cause mortality rate for renal adenocarcinoma increased from 1.07 per 100,000 in 2003 to 4.32 ± 0.06 per 100,000 in 2013, an annual percentage change of +15%. Age-adjusted mortality rates in the female population in Ireland increased from 0.78 to 2.66, an annual percentage change of +13.1% and from 1.41 to 6.04 in men, an annual percentage change of +15.8%.

Conclusion:

There is a paradox emerging in Ireland, with both rising survival rates for renal cell carcinoma and rising mortality rates. While the increased incidence of renal cell carcinoma in Ireland can be attributed somewhat to the increased use of various imaging modalities, it may also be attributed to the significant rise in modifiable risk factors as seen in other developed countries, namely hypertension, obesity, and smoking.

Level of evidence:

2c
Continued Contexts of Terror: Analyzing Temporal Patterns of Hashtag Co-Occurrence as Discursive Articulations
Authors: Eriksson Krutrök Moa , Lindgren Simon
Published: November 2018

This study looks at how terror attacks are rendered discursively meaningful on social media through the concurrent use and reiteration of terror hashtags, which were created following previous incidents of terror. The article focuses on 12 terror attacks in Europe in 2015-2017 and their relating hashtags on Twitter, to see how various combinations of these were reused and co-articulated in tweets posted in relation to subsequent attacks. Through social network analysis of co-occurring hashtags in about 3 million tweets, in combination with close readings of a smaller sample, this study aims to analyze both the networks of hashtags in relation to terror attacks as well as the discursive process of hashtag co-articulation. The study shows that the patterns by which attack hashtags are reused and co-articulated depend on both temporal and contextual differences.
360-Degree Complex Primary Reconstruction Using Porous Tantalum Cages for Adult Degenerative Spinal Deformity
Authors: Butler Joseph S. , Lui Darren F. , Malhotra Karan , Suarez-Huerta Maria L. , Yu Haiming , Selvadurai Susanne , Agu Obiekezie , Molloy Sean
Published: November 2018

Study Design:

Retrospective cohort study.

Objective:

To assess both implant performance and the amount of correction that can be achieved using multilevel anterior lumbar interbody fusion (ALIF).

Methods:

Retrospective cohort study (n = 178) performed over a 4-year period. Surgical variables examined included blood loss, operative time, perioperative complications, and secondary/revision procedures. Follow-up radiographic assessment was performed to record implant-related problems. Radiographic parameters were examined pre- and postoperatively. Health-related quality of life (HRQOL) outcome measures were collected preoperatively and at 6 weeks, 6 months, 1 year, and 2 years postoperatively. Descriptive and comparative statistical analysis, using paired-sample t test and repeated-measures analysis of variance (rANOVA), was performed.

Results:

Lumbar lordosis increased from 42° ± 17° preoperatively to 55° ± 11° postoperatively ( P < .001). The visual analog scale back pain mean score improved from 8.3 ± 1.5 preoperatively to 2.6 ± 2.4 at 2 years ( P < .001). The mean Oswestry Disability Index improved from 69.5 ± 21.5 preoperatively to 19.9 ± 15.2 at 2 years ( P < .001). The EQ-5D mean score improved from 0.2 ± 0.2 preoperatively to 0.8 ± 0.1 at 2 years ( P = .02). There were no neurological, vascular, or visceral approach–related injuries reported. No rod breakages and no symptomatic nonunions occurred. There was one revision procedure performed for fracture.

Conclusions:

The use of porous tantalum cages as part of a 360-degree fusion to treat adult degenerative spinal deformity has been demonstrated to be a safe and effective strategy, leading to good clinical, functional, and radiographic outcomes in the short term.
Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1
Authors: Jean-Charles Nathalie , Buenaventura Diego F. , Emerson Mark M.
Published: November 2018

Background

Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors or to generate new functional photoreceptors to replace those lost in the diseased retina. Cis-regulatory elements specific to cones, rods, or both types of photoreceptors are critical components of successful implementation of these two strategies. The purpose of this study was to identify and characterize the cell type specificity and activity of cis-regulatory elements active in developing photoreceptors.

Methods

Cis-regulatory elements were introduced into the developing chicken and mouse retina by electroporation. Characterization of reporter activity in relation with cell type markers was determined using confocal microscopy. In addition, two high-throughput flow cytometry assay were developed to assess whether these elements were downstream of Onecut1 in the photoreceptor specification network.

Results

The majority of cis-regulatory elements were active in both cone and rod photoreceptors and were largely uninfluenced by a Onecut1 dominant-negative construct. Elements associated with the Thrb, Nr2e3, and Rhodopsin genes showed highly enriched activity in cones or rods, and were affected by interference in Onecut1 signaling. Rhodopsin promoter activity was the most highly influenced by Onecut1 activity and its induction could be modulated by the Maf family transcription factor L-Maf. Nr2e3 elements were observed to have activity in cone photoreceptors and Nr2e3 protein was expressed in developing cone photoreceptors, suggesting a role for this predominant rod gene in cone photoreceptor development.

Conclusions

The analysis presented here provides an experimental framework to determine the specificity and strength of photoreceptor elements within specific genetic networks during development. The Onecut1 transcription factor is one such factor that influences the gene regulatory networks specific to cones and rods, but not those that are common to both.
3D vertical seismic profile acquired with distributed acoustic sensing on tubing installation: A case study from the CO2CRC Otway Project
Authors: Correa Julia , Pevzner Roman , Bona Andrej , Tertyshnikov Konstantin , Freifeld Barry , Robertson Michelle , Daley Thomas
Published: November 2018

Distributed acoustic sensing (DAS) can revolutionize the seismic industry by using fiber-optic cables installed permanently to acquire on-demand vertical seismic profile (VSP) data at fine spatial sampling. With this, DAS can solve some of the issues associated with conventional seismic sensors. Studies have successfully demonstrated the use of DAS on cemented fibers for monitoring applications; however, such applications on tubing-deployed fibers are relatively uncommon. Application of tubing-deployed fibers is especially useful for preexisting wells, where there is no opportunity to install a fiber behind the casing. In the CO2CRC Otway Project, we acquired a 3D DAS VSP using a standard fiber-optic cable installed on the production tubing of the injector well. We aim to analyze the quality of the 3D DAS VSP on tubing, as well as discuss lessons learned from the current DAS deployment. We find the limitations associated with the DAS on tubing, as well as ways to improve the quality of the data sets for future surveys at Otway. Due to the reduced coupling and the long fiber length (approximately 20 km), the raw DAS records indicate a high level of noise relative to the signal. Despite the limitations, the migrated 3D DAS VSP data recorded by cable installed on tubing are able to image interfaces beyond the injection depth. Furthermore, we determine that the signal-to-noise ratio might be improved by reducing the fiber length.
Left-right asymmetry in heart development and disease: forming the right loop
Authors: Desgrange Audrey , Le Garrec Jean-François , Meilhac Sigolène M.
Published: November 2018

Extensive studies have shown how bilateral symmetry of the vertebrate embryo is broken during early development, resulting in a molecular left-right bias in the mesoderm. However, how this early asymmetry drives the asymmetric morphogenesis of visceral organs remains poorly understood. The heart provides a striking model of left-right asymmetric morphogenesis, undergoing rightward looping to shape an initially linear heart tube and align cardiac chambers. Importantly, abnormal left-right patterning is associated with severe congenital heart defects, as exemplified in heterotaxy syndrome. Here, we compare the mechanisms underlying the rightward looping of the heart tube in fish, chick and mouse embryos. We propose that heart looping is not only a question of direction, but also one of fine-tuning shape. This is discussed in the context of evolutionary and clinical perspectives.
Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency, and cell of origin
Authors: Belyea Brian Chipman , Xu Fang , Sequeira-Lopez Maria Luisa Soledad , Gomez Roberto Ariel
Published: November 2018

Conditional deletion of RBP-J, the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B cell leukemia. However, the influence of contributing factors such as mouse strain, cell of origin, and cre recombinase copy number are unknown. In this study, we compared RBP-J deletion efficiency using 1 versus 2 copies of cre recombinase. Further, we compared the incidence and timing of leukemia development in two unique strains of mice, C57BL/6 and 129/Sv, as well as at different B cell developmental stages. We found that animals expressing 2 copies of cre recombinase developed B cell leukemia at an earlier age and with more fulminant disease. In addition, we found a difference in leukemia incidence between C57BL/6 and 129/SV mouse strains. Whereas deletion of RBP-J in renin-expressing cells of C57BL/6 mice leads to the development of B cell leukemia, 129/SV mice develop dermatitis with a reactive, myeloproliferative phenotype. The difference in phenotypes is explained in part by the differential expression of extra-renal renin; C57BL/6 mice have more renin-expressing cells within hematopoietic tissues. Finally, we found that deletion of RBP-J in Mb1- or CD19-expressing B lymphocytes does not result in leukemia development. Together, these studies establish that renin progenitors are vulnerable cells for neoplastic transformation and emphasize the importance of genetic background on the development of inflammatory and malignant conditions.
"Me and my students' smartphones in the classroom": A case study using arts-based methods
Authors: Vakali Eleni , Brailas Alexios
Published: November 2018

There is a new area flourishing within qualitative research based on methods using all forms of art: music, theatre, visual arts, and literature. In this paper we present an overview of the basic features of arts-based research; emphasizing on their meaning on education research, on the freedom of expression given to the participants in the research, and on the method the researcher applies to evaluate the collected data. We then present an arts-based research case study where the research questions relate to teachers’ reactions to the use of smartphones by students in the classroom. In this case study, teachers, especially those working on secondary education, are invited to portray their thoughts, emotions, and images that respond to these questions by painting them on a paper using markers. The findings show that the majority of the teachers are negative about the children using their smartphone in the classroom, along with evidence for teachers’ emotional response and how to confront the phenomenon.
Smartphones and their use by teenagers and young adults - differences and similarities: A case study
Authors: Papalexopoulou Konstantina , Psiachou Konstantina
Published: November 2018

Advances in Information and Communication Technologies (ICTs) promoted social media and social networking sites as an integral part of the psychosocial reality of modern people, especially the younger ones. This is an unprecedented form of networked lived experience, where people are always connected and always available through various social media platforms. How do teenagers who grew up in a given technosocial context perceive modern reality as compared to the slightly older young adults who, nevertheless, experienced a slightly different technosocial environment as children? Is there a kind of “generation gap” even among people who differ marginally in their age? In this case study we attempt a preliminary investigation of the field by conducting four ethnographic interviews with two teenagers and two young adults. Preliminary qualitative analysis showed increased use of smartphones by the participants, mostly for communication reasons and mainly through online services and social media. Both teenagers and young adults emphasize the effects of technology on everyday life and point out the potential risks, even though they remain optimistic for the future impact on human life. Our findings indicate that there are differences between the two age groups as regards their preferences for specific social media platforms and social apps.
The evolution and diversity of the nonsense-mediated mRNA decay pathway
Authors: Lloyd James P. B.
Published: November 2018

Nonsense-mediated mRNA decay is a eukaryotic pathway that degrades transcripts with premature termination codons (PTCs). In most eukaryotes, thousands of transcripts are degraded by NMD, including many important regulators of developmental and stress response pathways. Transcripts can be targeted to NMD by the presence of an upstream ORF or by introduction of a PTC through alternative splicing. Many factors involved in the recognition of PTCs and the destruction of NMD targets have been characterized. While some are highly conserved, others have been repeatedly lost in eukaryotic lineages. Here, I detail the factors involved in NMD, our current understanding of their interactions and how they have evolved. I outline a classification system to describe NMD pathways based on the presence/absence of key NMD factors. These types of NMD pathways exist in multiple different lineages, indicating the plasticity of the NMD pathway through recurrent losses of NMD factors during eukaryotic evolution. By classifying the NMD pathways in this way, gaps in our understanding are revealed, even within well studied organisms. Finally, I discuss the likely driving force behind the origins of the NMD pathway before the appearance of the last eukaryotic common ancestor: transposable element expansion and the consequential origin of introns.
Typification of Pinus torreyana Parry ex Carrière (Pinaceae) revisited
Authors: Wahlert Gregory A.
Published: November 2018

The name Pinus torreyana Parry ex Carrière has a convoluted nomenclatural history and a somewhat problematic typification. In this paper, the history surrounding the naming of P. torreyana Parry ex Carrière is briefly reviewed and the previous lectotypification is corrected to a neotypification. In addition, Pinus torreyana Parry ex Carrière and P. torreyana Parry ex Torr. are second‐step neotypified and lectotypified on the same specimen, respectively, resulting in the two names being treated as isonyms. Because Carrière’s description of Torrey pine is limited to the characteristics of seed and cone, where the measurements of the cone appear to be in error, P. torreyana is epitypified on a new collection from the type locality, which includes mature female cones. The disposition of three recently discovered duplicate specimens of the neotype of Pinus lophosperma Lindl. is clarified.
Criteria of truth
Authors: Борзых Станислав , Borzykh Stanislav
Published: November 2018

This book is devoted to such an important problem as understanding the world. The latter is impossible without relying on certain criteria that allow us to assess how close our understanding is to the truth. The text is therefore divided into three chapters. The first examines the question of human perception of the world, showing the fundamental, immanent shortcomings and physiological structure of our body and our mind, which prevent the perception of reality in its present form. The second considers our intellect as something finite and limited, also capable only of distortions and half-truths. Finally, the third shows that any intelligence (any intelligent creature, which appeared at our stage of development) a priori and in its essence put in a rigid framework implemented. The monograph is provided with an introduction and a final code, which are framework in nature and are designed, respectively, to give the reader a General idea of the work and draw some conclusions.
Evidência e existência ideal nas Investigações Lógicas de Husserl: uma análise sobre a conexão entre caracteres de ato e a estrutura das idealidades
Authors: Madalosso Yuri José Victor
Published: November 2018

Neste artigo, o objetivo geral é entender a relação entre o caráter posicional do conceito de evidência e a tese acerca da existência ideal dos objetos lógicos nas Investigações Lógicas (1900-1901), de Edmund Husserl. Especificamente, é mostrar que a problematização da estrutura posicional da evidência e conhecimento categoriais é necessária para a abordagem do conceito de existência ideal; além disso, irá explicitar que as limitações na diferenciação entre qualidade e posicionamento acarretam em dificuldades epistemológicas cruciais; por fim, mostrar a primazia do conceito de “síntese identificante”. Inicialmente, se fará a reconstrução do conceito de posicionalidade. Em seguida, será explicitada a concepção de evidência das Investigações Lógicas; logo após, será tematizado o conceito de existência ideal para, a seguir, apresentar os principais problemas e, finalmente, será realizado o enfrentamento destas dificuldades pela reconsideração classificatória do conceito de síntese e a reestruturação do conceito de “estado de coisas”.
O conceito de fenômeno no jovem Heidegger
Authors: López Francisco De Lara
Published: November 2018

Tradução de "El concepto de fenómeno en el joven Heidegger".O presente trabalho é uma discussão do conceito de fenômeno tal como este se encontra determinado na filosofia do jovem Heidegger. Com ela, pretende-se ir à base que permite elucidar em que sentido este faz fenomenologia ou, em outras palavras, qual ideia de fenomenologia se encontra expressada sob o título de hermenêutica fenomenológica. Em consonância com a leitura do conceito de fenômeno como conceito filosófico, isto é, como indicação formal, nos perguntaremos: 1) como se leva em consideração aquilo que é investigado fenomenologicamente; 2) como se deve aparecer aquilo que é assim investigado; e 3) se, de fato, o conceito de fenômeno funciona sempre em Heidegger como uma indicação formal ou se não se pode constatar nele uma certa ambiguidade.NdT: Este texto foi publicado originalmente na Eidos: Revista de Filosofía de la Universidad del Norte (ISSN: 1692-8857), n° 8, Barranquilla, maio de 2008, pp. 234-256. Tradução de Deborah Moreira Guimarães
Husserl e a metafísica da subjetividade: uma crítica heideggeriana a partir da noção de superação
Authors: Da Silva Ferreira Gustavo Augusto
Published: November 2018

A crítica de Heidegger àquilo que ele chama de metafísica da subjetividade tem seu momento mais elevado quando o mesmo volta os olhos para a filosofia fenomenológica de Husserl. Não podendo abrir mão da crítica da filosofia husserliana para a realização de seu projeto de crítica da metafísica da subjetividade enquanto continuação do esquecimento do ser inerente à história do pensamento ocidental, Heidegger propõe a superação da fenomenologia transcendental de Husserl pela fenomenologia hermenêutica. Tal superação constitui o cerne do projeto heideggeriano no todo de sua crítica da metafísica da subjetividade, esta última tendo seu auge em Husserl e, consequentemente, o auge de tal superação sendo a leitura crítica da filosofia de Husserl, no que tange à metafísica da subjetividade.
A MEMÓRIA E O TESTEMUNHO NA CONSTRUÇÃO NARRATIVA DE COMBATEREMOS A SOMBRA DE LÍDIA JORGE
Authors: Ramos Talita De Barcelos
Published: November 2018

O presente trabalho tem como objetivorealizar a análise da obra Combateremos asombra, publicado em 2007, de autoria daescritora portuguesa Lídia Jorge.Buscaremos compreender a função damemória e do testemunho, tanto no quediz respeito à construção narrativa,quanto à análise temática dospersonagens. Para tanto, utilizaremos aproposta de Santo Agostinho emConfissões, de Nietzsche em Genealogiada moral, de Paul Ricoeur em A memória,a história, o esquecimento e de Seligmann-Silva em Apresentação da questão: aliteratura do trauma e O testemunho:entre a ficção e o real. O intuito é o depromover uma reflexão acerca do modocomo a questão da memória surge nointerior do romance e a sua intrínsecarelação com o testemunho.
A escritura biografemática em O irmão alemão: rastros de leituras na autoficção buarquiana
Authors: Elesbão Juliane De Sousa
Published: November 2018

Com base na autoficção como recursoartístico-literário para a ficcionalização desi e no conceito de biografema, propomosneste trabalho uma leitura da narrativabuarquiana O irmão alemão publicada em2014. Através dos rastros de leiturasidentificados no decorrer da narrativa, edo modo como a literatura funciona comomediadora entre o protagonista, o Ciccio,e os demais personagens do romancereferido, objetivamos mostrar que asproblematizações manifestadas em Oirmão alemão ultrapassam oacontecimento tido como principal doenredo: a descoberta de e a busca por ummeio-irmão alemão de Ciccio. Sendoassim, ficção, realidade e autor, porexemplo, são instâncias colocadas sobreflexão na escritura de Chico Buarque.
A MEMÓRIA LITERÁRIA E OS FOLHETINS PUBLICADOS EM RIO GRANDE
Authors: Mello Juliane Cardozo de
Published: November 2018

O presente artigo trata da importância dapreservação do patrimônio culturalbrasileiro, mais especificamente damemória literária conservada em acervosde arquivos públicos e privados, por meioda análise dos folhetins publicados emperiódicos, na cidade de Rio Grande (RS),no decorrer do século XIX. Além disso,conceitua a propagação do gênerofolhetim no Brasil e apresenta obrasdesconhecidas ou consideradas“desaparecidas” pela crítica ehistoriografia literária, centrando-se nasseguintes narrativas: Lúcia de Miranda(1851), de Candido Batista de Oliveira eUm drama no mar (1862), de Carlos vonKoseritz.
César Vallejo e a consciência da morte
Authors: Diógenes Danilo
Published: November 2018

A proposta deste trabalho é analisar opensamento de César Vallejo (1892 -1938) sobre a consciência que o homempossui de sua própria mortalidade. Paraisso, percorremos alguns poemas quetratam do tema da morte, por meio de umraciocínio metafísico em diferentes fasesda produção poética do autor. Nos doisextremos estão “Los heraldos negros”(1918) e “La violencia de las horas” (1939).César Vallejo empreende, nesses poemas,uma investigação do sofrimento e dadificuldade de se cumprir um destino quenos foi reservado desde o nossonascimento: a morte.
Jane Austen e a identidade nacional nostálgica da Inglaterra
Authors: Biajoli Maria Clara Pivato
Published: November 2018

O presente artigo analisa o processo dereconstrução da obra da escritora inglesaJane Austen (1775-1817) desde o fim doséculo XIX até o período pós-SegundaGuerra Mundial. Esse processo é, emgrande parte, responsável pela imagem,que ainda circula atualmente, de seusromances como retratos pacíficos ecampestres de uma Inglaterra pré-Revolução Industrial que foi perdida namodernidade mas que, ainda assim,constitui a essência da identidade inglesa.Trata-se de uma reconstrução que ocorreutanto no âmbito acadêmico quanto pormeio da veneração de seus fãs, osJaneites, e que resultou na transformaçãode Austen em um patrimônio a serpreservado. Tal resultado, além deconsolidar uma interpretação sobre aautora e sua obra, pode ser observadotanto na criação de um museu em suaúltima casa, Chawton Cottage, como nagrande atração de turistas pelos locaismencionados em seus romances ouutilizados como cenários nas recentesadaptações de suas obras para cinema etelevisão.
O espaço como representação dos personagens em Chove nos campos de cachoeira, de Dalcídio Jurandir
Authors: Guzzon Francidalva Araújo , Rech Alessandra Paula
Published: November 2018

Na obra de Dalcídio Jurandir, o espaço sesobressai particularmente, a ponto de setornar a representação das sutilezaspsicológicas dos personagens. Naperspectiva da imaginação espacial deBachelard, este artigo tem por objetivodemonstrar de que forma as descrições dapaisagem falam sobre personagenspresentes em Chove nos campos decachoeira e, ao mesmo tempo,evidenciam os contornos típicos do Pará.O referencial teórico contempla, ainda,Ozíris Filho.
CHLORIS CASAGRANDE JUSTEN: VERSOS DE MEMÓRIA E RESISTÊNCIA
Authors: Zanesco Vanessa Micheli Faraom
Published: November 2018

Este estudo tem por objetivo investigarrepresentações da memória nos textospoéticos da escritora Chloris CasagrandeJusten (1923), que exprime umalinguagem marcada pela subjetividade desuas palavras. Nos poemas selecionadosdas obras Jogo de luz (1993) e Essênciastransfiguradas (2011), a memória nãoconvém como caráter informativo, masprima pelo envolvimento de rememorarfatos que permaneceram em outrotempo, fazendo refletir sobre a realidadeque foi sensoriada para constituir asimagens, a memória lírica e social, as quaisrevelam a nostalgia recorrente nos versosjustinianos. O tema da memória coletiva eindividual, que envolve o atavismo e aresistência, aparece para reforçar aindamais a presença do recordar.
HOLOCAUSTO BRASILEIRO: O RESGATE DA MEMÓRIA NO JORNALISMO LITERÁRIO DE DANIELA ARBEX
Authors: Sangaletti Leticia , Bisol Laísa Veroneze
Published: November 2018

O intuito deste artigo é verificar como amemória se constrói na obra de jornalismoliterário de Daniela Arbex, “HolocaustoBrasileiro”, a partir da narrativa textual. Ametodologia parte da leitura da obra emconsonância com o aporte bibliográfico esegue com uma análise descritiva ecomparativa, que mescla as percepçõespresentes no texto e nas imagensselecionadas. Para tanto, utilizamos comoaporte teórico, entre outros autores, MauriceHalbwachs e Paul Ricoeur acerca da Memória.Os resultados da análise do trabalho apontampara o resgate da memória através das formasde narrativa utilizadas na obra, a partir deuma releitura do passado, partindo daindividualidade para o coletivo, tanto noresgate, quanto na divulgação dessasmemórias.
IMAGENS DA MEMÓRIA BELO HORIZONTINA EM (RE)VISITA À RUA DA BAHIA
Authors: Oliveira Isa Maria Marques de , Pires Antonia Cristina De Alencar
Published: November 2018

Este artigo tem como eixo a relação entreliteratura, memória urbana e patrimôniocultural. Tomamos como objeto deobservação de tal relação a Rua da Bahia,em Belo Horizonte/MG. Esta rua, desde ainauguração da capital, apresentou-secomo lugar de efervescência cultural, dadaa intensa movimentação dos moradorespor suas calçadas e estabelecimentos,tornando-se local de encontros daintelectualidade belo-horizontina. Foi naRua da Bahia que se formou a primeirageração de escritores modernistas belo-horizontinos. Esta geração dedicou-lheuma infinidade de textos e horas defrequência, assim como outras geraçõesde intelectuais que lhe sucederam,criando uma espécie de tradição econferindo-lhe o estatuto de patrimônioafetivo e cultural de BH, tanto do ponto devista material, pois nela se encontramprédios de várias épocas e tendênciasarquitetônicas, quanto do ponto de vistaimaterial, uma vez que ainda é lugar dehábitos e costumes remanescentes doinício da capital.
LITERATURA E HISTÓRIA: EXPRESSÕES FICCIONAIS OU REAIS?
Authors: Santana Cristian Paula
Published: November 2018

Viso, neste artigo, relacionar Literatura,História e Memória através dos conceitosligados à metaficção historiográfica e àpós-modernidade. Para maior eficácia,proponho, ao invés de uma revisãoconceitual, buscar as teorias diretamentenas obras literárias. Para tanto, utilizareicomo base as obras São Bernardo (1994)de Graciliano Ramos e A hora da estrela(1998) de Clarice Lispector para refletirsobre a metaficção; o conto Teorema(1970) de Herberto Helder para pensar ahistória e Um cinturão (1981) deGraciliano Ramos para discorrer a cerca damemória.
Resenha de Rio-paris-rio
Authors: Oliveira Márcio Alessandro de
Published: November 2018

HIDALGO, Luciana. Rio-Paris-Rio. 1. ed. Rio de Janeiro: Rocco, 2016, 159 páginas. ISBN978-85-325-2989-3.
Expediente da edição 27
Authors: Editorial Comissão
Published: November 2018

Expediente da edição 27
Metabolic and morphometric changes in Indonesian cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet composed of locally sourced ingredients
Authors: Laila Sri Rahmatul , Astuti Dewi Apri , Suparto Irma Herawati , Handharyani Ekowati , Sajuthi Dondin
Published: November 2018

Background and Aim: This study was designed to determine the effects of a new atherogenic diet formulated at Institut Pertanian Bogor (IPB) (Bogor, Indonesia) on metabolic, morphometric, and carotid artery imaging of cynomolgus monkeys.

Materials and Methods: A total of 20 adult male cynomolgus monkeys fed IPB-1 atherogenic diet for 1 year. Total plasma cholesterol (TPC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and morphometric measurements were evaluated at baseline and monthly during the study. Carotid plaques and intima-media thickness (IMT) were measured using ultrasonography at baseline and after 8 months of treatment.

Results: This diet increased TPC, LDL, and TPC/HDL ratio and induced carotid atherosclerosis in this model. The TPC, LDL, and TPC/HDL ratio were positively associated; however, HDL was negatively associated with carotid plaques and IMT.

Conclusion: The IPB-1 atherogenic diet formulated with locally and readily available ingredients provides an economically and scientifically feasible monkey model to study atherosclerosis in Indonesia and Southeast Asia.
Simulation of Arc Motion in Alternating Mahnetic Field Using Dimensionless Momentum Equation
Authors: Takeda K. , Akiho R.
Published: November 2018

A new heat-treatment system has been developed using an arc driven by an alternating magnetic field. The arc motion was theoretically investigated by the method of non-dimensional
analysis. After the definition of the pertinent characteristic length and time, the momentum equation was converted into the dimensionless form. This approach gave us not only a short cut to simulate the arc motion but also clear understanding on the nature of the magnetically driven arc.
Distribusi Nematoda Pucuk Putih Padi Aphelenchoides besseyi di Pulau Jawa
Authors: Diana Didiet Rahayu
Published: November 2018

Distribution of Rice White Tip Nematode Aphelenchoides besseyi in Java Island    Aphelenchoides besseyi is one of the most important rice seed borne nematode causing white tip disease in Indonesia.  The status of A. besseyi is considered as quarantine pest category A2, with limited distribution area in Java, Sumatera, and South Kalimantan). The aim of this research was to detect and identify A. besseyi from rice seed based on morphological, morphometry and molecular approaches and to determine its distribution in rice growing areas in Java. Rice seed samples, consisting of 26 varieties, were obtained from seed producers, seed distributors, and farmers in Java. Nematode extraction was done using Baermann method. Molecular identification was carried out by polymerase chain reaction and followed by DNA sequencing and nucleotide analysis. A. besseyi was detected from 74.32% of seed samples. A. besseyi was confirmed to be distributed in Lebak, Bogor, Sukabumi, Subang, Indramayu, Klaten, Sragen, Sukoharjo, Boyolali, Pati, Pemalang, Yogyakarta Sleman, Magetan, Blitar, Tuban, Gresik, Nganjuk, and Banyuwangi. Further nucleotide analysis showed that A. besseyi isolates from rice seed cv Ciherang (Yogyakarta) and cv IR 64 (Banyuwangi) have 99% homology to those from India, China, USA; and  98% homology to those from Taiwan.
LEGAL PERSPECTIVE ON ASEAN ECONOMIC COMMUNITY
Authors: Hartono Darminto , Hardiwinoto Soekotjo
Published: November 2018

Since 2015, the ASEAN Economic Community (AEC) applied in its member countries, Including Indonesia. The preparation effort is regulatory legislation related to the AEC as a guide to achieve country's goals. The research aims to focus on how to inventory of the AEC regulations and how to find out in passing the AEC. The method uses the normative juridical approach and qualitative descriptive data analysis method. These research results that have a global market share, exporting country, investment destination country, a liberalization of ASEAN goods trade, large demographic bonuses, open services sector, aand smoother capital flows constantly. While the challenge is the elevation of the rate of export-import and the inflation rate, the negative impact of broader capital flows, the similarity of export products Which is still diverse must be solved. The Indonesian Government has an authority to regulate the role and function through it policies optimally, because of the opportunities and the existence of Indonesia. It is a matter of course that each member country to face AEC still not enough of expectations.
YURIDICAL ANALYSIS OF THEORY OF THEORY OF ETHICAL FACILITIES DUTIES LAW COMPETITION COMPETITION IN INDONESIA
Authors: Wardhana Nandi
Published: November 2018

Indonesian competition law today requires a renewal of one of them concerning the doctrine of essential facilities duties. The doctrine essential facilities duties is a doctrine imposed on a dominant business actor who has access to essential facilities to provide access for competing business actors to use the facility. Regulation of essential facilities duties are needed to reduce dominance of a dominant firm in a particular market. This study uses a statutory approach, conceptual approach, and a comparative approach between the arrangements in the United States, Europe and Indonesia. The approach is expected to illustrate, harmonize problems arising, and provide better legal protection in the world of business competition. The doctrine essential facilities duties were first applied in the United States and then followed by European countries. The doctrine of essential facilities duties in the United States is based on the sherman act and uses theapproach rule of reason. The doctrine of essential facilities duties in European countries based on EC focuses on refusal to deal. The doctrine of essential facilities duties is explicitly implied in Law No. 5 of 1999. From this study it is concluded that the regulation on essential facilities duties in Law No. 5 of 1999 still can not provide a good legal protection for business competition in Indonesia.