bluuebunny/crossref_metadata_2025 huggingface dataset:
Hot flash report and measurement among Bangladeshi migrants, their London neighbors, and their community of origin
Authors: Sievert L. L. , Begum K. , Sharmeen T. , Murphy L. , Whitcomb B. W. , Chowdhury O. , Muttukrishna S. , Bentley G. R.
Published: August 2016

Objectives

To examine hot flashes in relation to climate and activity patterns, and to compare subjective and objective hot flashes among Bangladeshi immigrants to London, their white London neighbors, and women still living in their community of origin, Sylhet, Bangladesh (“sedentees”).

Methods

Ninety‐five women, aged 40–55, wore the Biolog ambulatory hot flash monitor. Objective measurements and subjective hot flash reports were examined in relation to demographic, reproductive, anthropometric, and lifestyle variables; temperature and humidity at 12:00 and 18:00; and time spent on housework and cooking. Concordance of objective and subjective hot flashes was assessed by Kappa statistics and by sensitivity of hot flash classification.

Results

During the study period, Bangladeshi sedentees reported more subjective hot flashes (p < .05), but there was no difference in number of objective hot flashes. White Londoners were more likely to describe hot flashes on their face and neck compared to Bangladeshis (p < .05). Sedentees were more likely to describe hot flashes on their feet (p < .05). Postmenopausal status, increasing parity, and high levels of housework were significant determinants of subjective hot flashes, while ambient temperature and humidity were not. Measures of subjective/objective concordance were low but similar across groups (10–20%). The proportion of objective hot flashes that were also self‐reported was lowest among immigrants.

Discussion

Hot flashes were not associated with warmer temperatures, but were associated with housework and with site‐specific patterns of cooking. The number of objective hot flash measures did not differ, but differences in subjective experience suggest the influence of culture.
Positive selection of lactase persistence among people of Southern Arabia
Authors: Bayoumi Riad , De Fanti Sara , Sazzini Marco , Giuliani Cristina , Quagliariello Andrea , Bortolini Eugenio , Boattini Alessio , Al‐Habori Molham , Al‐Zubairi Adel Sharaf , Rose Jeffrey I. , Romeo Giovanni , Al‐Abri Abdulrahim , Luiselli Donata
Published: August 2016

Objective

Frequency patterns of the lactase persistence (LP)‐associated −13,915 G allele and archaeological records pointing to substantial role played by southern regions in the peopling and domestication processes that involved the Arabian Peninsula suggest that Southern Arabia plausibly represented the center of diffusion of such adaptive variant. Nevertheless, a well‐defined scenario for evolution of Arabian LP is still to be elucidated and the burgeoning archaeological picture of complex human migrations occurred through the peninsula is not matched by an equivalent high‐resolution description of genetic variation underlying this adaptive trait. To fill this gap, we investigated diversity at a wide genomic interval surrounding the LCT gene in different Southern Arabian populations.

Methods

40 SNPs were genotyped to characterize LCT profiles of 630 Omani and Yemeni individuals to perform population structure, linkage disequilibrium, population differentiation‐based and haplotype‐based analyses.

Results

Typical Arabian LP‐related variation was found in Dhofaris and Yemenis, being characterized by private haplotypes carrying the −13,915 G allele, unusual differentiation with respect to northern groups and conserved homozygous haplotype‐blocks, suggesting that the adaptive allele was likely introduced in the Arabian gene pool in southern populations and was then subjected to prolonged selective pressure.

Conclusion

By pointing to Yemen as one of the best candidate centers of diffusion of the Arabian‐specific adaptive variant, obtained results indicate the spread of indigenous groups as the main process underlying dispersal of LP along the Arabian Peninsula, supporting a refugia model for Arabian demic movements occurred during the Terminal Pleistocene and Early Holocene.
Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction
Authors: Zeymer Cathleen , Werbeck Nicolas D. , Zimmermann Sabine , Reinstein Jochen , Hansen D. Flemming
Published: August 2016

States along the phosphoryl transfer reaction catalyzed by the nucleoside monophosphate kinase UmpK were captured and changes in the conformational heterogeneity of conserved active site arginine side‐chains were quantified by NMR spin‐relaxation methods. In addition to apo and ligand‐bound UmpK, a transition state analog (TSA) complex was utilized to evaluate the extent to which active site conformational entropy contributes to the transition state free energy. The catalytically essential arginine side‐chain guanidino groups were found to be remarkably rigid in the TSA complex, indicating that the enzyme has evolved to restrict the conformational freedom along its reaction path over the energy landscape, which in turn allows the phosphoryl transfer to occur selectively by avoiding side reactions.
Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C−O Bond Formation under Mild Conditions
Authors: Alvarado Joseph , Fournier Jeremy , Zakarian Armen
Published: August 2016

A method for the synthesis of dihydrobenzofurans by a direct aryl C−O bond formation is described. A mechanistic pathway for the reaction, distinct from previously described similar transformations, allows for mild reaction conditions that are expected to be compatible with functionalized substrates.
Serum nitrite and nitrate levels, NOx, can predict cardiovascular mortality in the elderly in a 3‐year follow‐up study
Authors: Gumanova Nadezhda G. , Deev Alexander D. , Zhang Wei , Kots Alexander Y. , Shalnova Svetlana A.
Published: August 2016

Nitric oxide (NO) is an important functional regulator that contributes to progression of various cardiovascular diseases. We studied associations between nitric oxide metabolites, nitrite and nitrate (NOx), and cardiovascular mortality in a prospective 3‐year follow‐up cohort study in 1,869 elderly patients aged over 55 years. The Cox proportional hazard regression model was adjusted for multiple factors including sex, age, risk corresponding to preexisting cardiovascular conditions, and serum inflammatory markers (C‐reactive protein, interleukin‐6, fibrinogen, and leucocytes count). During the follow‐up period, there were a total of 348 deaths including 216 deaths unrelated to cardiovascular events and 132 cardiovascular deaths. Cox regression adjusted for factors related to cardiovascular disease risks and inflammatory markers showed a significant association between high levels of serum nitric oxide metabolites, NOx, and increased cardiovascular mortality (hazard ratio 2.21; 95% confidence interval 1.13–4.31) but there was no association with non‐cardiovascular mortality. Analysis of adjusted hazard ratios demonstrates that association of serum nitric oxide metabolites with cardiovascular mortality was independent of levels of inflammatory markers. Thus, elevated concentrations of serum nitric oxide metabolites are a predictor of cardiovascular mortality and may be used as an integral marker of cardiovascular death. © 2016 BioFactors, 43(1):82–89, 2017
Tetrazine Assists Reduction of Water by Phosphines: Application in the Mitsunobu Reaction
Authors: Polezhaev Alexander V. , Maciulis Nicholas A. , Chen Chun‐Hsing , Pink Maren , Lord Richard L. , Caulton Kenneth G.
Published: August 2016

Reaction of 3,6‐disubstituted‐1,2,4,5‐tetrazines with water and PEt3 forms the corresponding 1,4‐dihydrotetrazine and OPEt3. Thus PEt3, as a stoichiometric reductant, reduces water, and the resulting two reducing equivalents serve to doubly hydrogenate the tetrazine. A variety of possible initial interactions between electron‐deficient tetrazine and electron‐rich PR3, including a charge transfer complex, were evaluated by density functional calculations which revealed that the energy of all these make them spectroscopically undetectable at equilibrium, but one of these is nevertheless suggested as the intermediate in the observed redox reaction. The relationship of this to the Mitsunobu reaction, which absorbs the components of water evolved in the conversion of alcohol and carboxylic acid to ester, with desirable inversion at the alcohol carbon, is discussed. This enables a modified Mitsunobu reaction, with tetrazine replacing EtO2CN=NCO2Et (DEAD), which has the advantage that dihydrotetrazine can be recycled to tetrazine by oxidation with O2, something impossible with the hydrogenated DEAD. For this tetrazine version, a betaine‐like intermediate is undetectable, but its protonated form is characterized, including by X‐ray structure and NMR spectroscopy.
Reaction of [TpRh(C2H4)2] with Dimethyl Acetylenedicarboxylate: Identification of Intermediates of the [2+2+2] Alkyne and Alkyne–Ethylene Cyclo(co)trimerizations
Authors: Bottari Giovanni , Santos Laura L. , Posadas Cristina M. , Campos Jesús , Mereiter Kurt , Paneque Margarita
Published: August 2016

The reaction between the bis(ethylene) complex [TpRh(C2H4)2], 1, (Tp=hydrotris(pyrazolyl)borate), and dimethyl acetylenedicarboxylate (DMAD) has been studied under different experimental conditions. A mixture of products was formed, in which TpRhI species were prevalent, whereas the presence of trapping agents, like water or acetonitrile, allowed for the stabilization and isolation of octahedral TpRhIII compounds. An excess of DMAD gave rise to a small amount of the [2+2+2] cyclotrimerization product hexamethyl mellitate (6). Although no catalytic application of 1 was achieved, mechanistic insights shed light on the formation of stable rhodium species representing the resting state of the catalytic cycle of rhodium‐mediated [2+2+2] cyclo(co)trimerization reactions. Metallacyclopentene intermediate species, generated from the activation of one alkyne and one ethylene molecule from 1, and metallacyclopentadiene species, formed by oxidative coupling of two alkynes to the rhodium centre, are crucial steps in the pathways leading to the final organometallic and organic products.
Fluorescent Peptide Beacons for the Selective Ratiometric Detection of Heparin
Authors: Maity Debabrata , Schmuck Carsten
Published: August 2016

Heparin is extensively used as an anticoagulant drug during surgery. Two fluorophore‐functionalized cationic oligopeptides HS 1 and HS 2 were developed to monitor heparin ratiometrically in aqueous media. Upon binding to heparin, HS 1 and HS 2 undergo a conformational change from an open form to a folded form, which leads to a distinct change in the fluorescence properties. HS 1 switches from pyrene monomer emission to an excimer emission. For HS 2, a fluorescence resonance energy transfer (FRET) process is enabled between a naphthalene donor and a dansyl acceptor. This method is highly selective for heparin relative to other similar biological analytes such as hyaluronic acid or chondroitin sulfate. HS 1 and HS 2 could also detect heparin ratiometrically in diluted bovine serum. The strong ratiometric emission color change can also be observed by the naked eye. Addition of the polycationic protein protamine releases both HS 1 and HS 2 from their heparin complex, which simultaneously restores pyrene monomer emission for the first case and decreases the FRET process for the latter case, respectively. Dynamic light scattering (DLS) and AFM studies confirm aggregate formation of heparin with HS 1 and HS 2.
Seeded Supramolecular Polymerization in a Three‐Domain Self‐Assembly of an N‐Annulated Perylenetetracarboxamide
Authors: Greciano Elisa E. , Sánchez Luis
Published: August 2016

The three‐domain cooperative supramolecular polymerization of 1, together with the lag time in which the monomeric species remains inactive, allows seeded supramolecular polymerization to be performed. The kinetic experiments demonstrate that only seeds based on the intermediate aggregate are able to propagate the supramolecular polymerization of 1 from their active sites. The results presented herein constitute a new example of kinetically controlled supramolecular systems and contribute to expanding knowledge about the structural requirements of a self‐assembling molecule to experience seeded supramolecular polymerization.
Hydroboration as an Efficient Tool for the Preparation of Electronically and Structurally Diverse N→B‐Heterocycles
Authors: Grandl Markus , Kaese Thomas , Krautsieder Anke , Sun Yu , Pammer Frank
Published: August 2016

Ladder‐type organoboranes featuring intramolecular N→B coordination have been prepared through hydroboration of a 2‐(ortho‐styryl)pyridine (PhPy) with a series of hydroboranes, including 9H‐9‐borabicyclo[3.3.1]nonyl (9H‐BBN), BH3⋅THF, HBCl2⋅SMe2, HB(C6F5)2, and a 9H‐9‐borafluorene derivative. The hydroboration reaction results in highly regioselective borylation under mild conditions and gives the products in good to excellent yields. The molecular structure and electronic properties of the obtained boranes have been experimentally investigated in detail, and complemented with DFT calculations to further elucidate the origin of differences in optical and electronic properties. The electron affinity of the conjugated system can be controlled through variation of the borane, while the optical properties are likewise directly linked to the type and molecular structure of the substituents on boron. The broad substrate range shows that this preparative approach is widely applicable to introduce chemically diverse boryl groups into conjugated systems.
Selective Hydrosilylation of Esters to Aldehydes Catalysed by Iridium(III) Metallacycles through Trapping of Transient Silyl Cations
Authors: Corre Yann , Rysak Vincent , Capet Frédéric , Djukic Jean‐Pierre , Agbossou‐Niedercorn Francine , Michon Christophe
Published: August 2016

The combination of an iridium(III) metallacycle and 1,3,5‐trimethoxybenzene catalyses rapidly and selectively the reduction of esters to aldehydes at room temperature with high yields through hydrosilylation followed by hydrolysis. The ester reduction involves the trapping of transient silyl cations by the 1,3,5‐trimethoxybenzene co‐catalyst, supposedly by formation of an arenium intermediate whose role was addressed by DFT calculations.
Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch
Authors: Basílio Nuno , Pischel Uwe
Published: August 2016

The reversibly switchable trans‐chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug‐cucurbit[7]uril host–guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.
Readily Accessible and Predictable Naphthalene‐Based Two‐Photon Fluorophore with Full Visible‐Color Coverage
Authors: Koo Ja Young , Heo Cheol Ho , Shin Young‐Hee , Kim Dahahm , Lim Chang Su , Cho Bong Rae , Kim Hwan Myung , Park Seung Bum
Published: August 2016

Herein we report 22 acedan‐derived, two‐photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two‐photon excitation with single wavelength, and to design a turn‐on, two‐photon fluorescence sensor for endogenous H2O2 in Raw 264.7 macrophage and rat brain hippocampus ex vivo.
Experimental and Computational Studies on the Formation of Thorium–Copper Heterobimetallics
Authors: Yang Pikun , Zhou Enwei , Hou Guohua , Zi Guofu , Ding Wanjian , Walter Marc D.
Published: August 2016

The formation of actinide–transition metal heterobimetallics mediated by a terminal actinide imido complex was comprehensively studied. The reaction of the thorium imido complex [(η5‐C5Me5)2Th=N(mesityl)(DMAP)] (3), prepared from [(η5‐C5Me5)2ThMe2] (1) and mesitylNH2 or [(η5‐C5Me5)2Th(NHmesityl)2] (2) in the presence of 4‐(dimethylamino)pyridine (DMAP), with copper(I) halides gave the first thorium–copper heterobimetallic compounds [(η5‐C5Me5)2Th(X){N(mesityl)Cu(DMAP)}] (X=Cl (4), Br (5), I (6)). Complexes 4–6 feature an unusual geometry with a short Th−Cu distance, which DFT studies attribute to a weak donor–acceptor bond from the Cu+ atom to the electropositive Th4+ atom. They are reactive species, as was shown by their reaction with the dimethyl complex [(η5‐C5Me5)2ThMe2] (1). Furthermore, a comparison between Th and early transition metals confirmed that Th4+ exhibits distinctively different reactivity from d‐transition metals.
In Situ Solid‐State Reactions Monitored by X‐ray Absorption Spectroscopy: Temperature‐Induced Proton Transfer Leads to Chemical Shifts
Authors: Stevens Joanna S. , Walczak Monika , Jaye Cherno , Fischer Daniel A.
Published: August 2016

The dramatic colour and phase alteration with the solid‐state, temperature‐dependent reaction between squaric acid and 4,4′‐bipyridine has been probed in situ with X‐ray absorption spectroscopy. The electronic and chemical sensitivity to the local atomic environment through chemical shifts in the near‐edge X‐ray absorption fine structure (NEXAFS) revealed proton transfer from the acid to the bipyridine base through the change in nitrogen protonation state in the high‐temperature form. Direct detection of proton transfer coupled with structural analysis elucidates the nature of the solid‐state process, with intermolecular proton transfer occurring along an acid‐base chain followed by a domino effect to the subsequent acid‐base chains, leading to the rapid migration along the length of the crystal. NEXAFS thereby conveys the ability to monitor the nature of solid‐state chemical reactions in situ, without the need for a priori information or long‐range order.
ChemInform Abstract: Synthesis and Characterization of Orthovanadates Compounds Li(1‐x)NaxCdVO4 (x = 0, 0.25).
Authors: Djemal Amal , Louati Bassem , Guidara Kamel
Published: August 2016

LiCdVO4 (I) and Li0.75Na0.25CdVO4 (II) are prepared by solid state reaction of stoichiometric mixtures of Li2CO3, Na2CO3, V2O5, and CdO (953 K (I) and 1000 K (II), 12 h).
ChemInform Abstract: Gd12Co5.3Bi and Gd12Co5Bi, Crystalline Doppelgaenger with Low Thermal Conductivities.
Authors: Oliynyk Anton O. , Sparks Taylor D. , Gaultois Michael W. , Ghadbeigi Leila , Mar Arthur
Published: August 2016

Single crystals of Gd12Co5.3Bi are grown from elemental mixtures in the ratio 12:5:1 using small amounts of I2 in a small temperature gradient (evacuated silica tubes, 800→≈798 °C, 2 d).
ChemInform Abstract: Strongly Exchange Coupled Core|Shell Nanoparticles with High Magnetic Anisotropy: A Strategy Toward Rare‐Earth‐Free Permanent Magnets.
Authors: Lottini E. , Lopez‐Ortega A. , Bertoni G. , Turner S. , Meledina M. , Van Tendeloo G. , de Julian Fernandez C. , Sangregorio C.
Published: August 2016

Antiferromagnetic(AFM)/ferrimagnetic(FiM) Co0.3Fe0.7O/Co0.6Fe2.4 O4 core‐shell nanoparticles (NPs) with a particle size of 6—18 nm are prepared by a one‐pot thermal decomposition process according to the literature involving mixed Fe and Co oleate complexes.
ChemInform Abstract: High Nuclearity Antimonato‐Polyoxovanadate Cluster {V15Sb6O42} as a Synthon for the Solvothermal in situ Generation of α‐ and β‐{V14Sb8O42} Isomers.
Authors: Wendt Michael , Naether Christian , Bensch Wolfgang
Published: August 2016

The high‐nuclearity cluster compound (I) is shown to be an excellent new synthon for the preparation of (II) containing the β‐V14Sb8O42 isomer and the new compound (V) containing the α‐V14Sb8O42 isomer.
ChemInform Abstract: Iridium‐Catalyzed Diastereoselective and Enantioselective Allylic Substitutions with Acyclic α‐Alkoxy Ketones.
Authors: Jiang Xingyu , Chen Wenyong , Hartwig John F.
Published: August 2016

Allylic substitution reactions with acyclic α‐alkoxy ketones are catalyzed by a metallacyclic iridium complex to form products with contiguous stereogenic centers derived from the nucleophile and electrophile.
ChemInform Abstract: Electrophilic Activation of α,β‐Unsaturated Amides: Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ‐Butyrolactones.
Authors: Zhang Ming , Kumagai Naoya , Shibasaki Masakatsu
Published: August 2016

α,β‐Unsaturated 7‐azaindoline amides act as reactive electrophiles in diastereo‐ and enantioselective vinylogous conjugate additions of γ‐butyrolactones in the presence of a cooperative catalyst comprising a soft Lewis acid and a Broensted base.
ChemInform Abstract: Synthesis of Functionalized 2‐Trifluoromethylquinolines and Their Heteroaromatic Analogues.
Authors: Khutoryanskiy Viktor V. , Biitseva Angelina V. , Mykhailiuk Pavel K.
Published: August 2016

by cyclization of electron‐rich anilines with heterocyclic CF3‐containing amines
ChemInform Abstract: Primary Polyfluoroalkanethioamides as Mild Thioacylating Reagents for Alkyl Amines and α‐Amino Acid Esters.
Authors: Pikun Nadiia V. , Mykhaylychenko Sergiy S. , Kulik Irine B. , Shermolovich Yuriy G.
Published: August 2016

New polyfluoroalkanethioyl derivatives are prepared by transamidation of primary amides of polyfluoroalkanethiocarboxylic acids with alkyl amines under mild reaction conditions.
ChemInform Abstract: A General Method for Aminoquinoline‐Directed, Copper‐Catalyzed sp2 C—H Bond Amination.
Authors: Roane James , Daugulis Olafs
Published: August 2016

Primary, secondary, and aromatic amines, heterocycles as well as electron‐deficient aromatic and heteroaromatic are employed as amine coupling partners using Cu(OAc)2 or CuCO3·Cu(OH)2 as catalysts and oxygen from the air as the terminal oxidant.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling of (Hetero)aryl Chlorides with Aryllithium Compounds.
Authors: Tao Jian‐Long , Wang Zhong‐Xia
Published: August 2016

A nickel pincer complex catalyzes cross‐coupling reactions of aryl or heteroaryl chlorides with aryllithiums to give biaryls under mild reaction conditions.
ChemInform Abstract: Nickel‐Catalyzed Carboxylation of Benzylic C—N Bonds with CO2.
Authors: Moragas Toni , Gaydou Morgane , Martin Ruben
Published: August 2016

An user‐friendly Ni‐catalyzed reductive carboxylation of benzylic C—N bonds with CO2 is described.
ChemInform Abstract: Microwave Assisted Multi‐Component Synthesis of Novel Bis(1,4‐dihydropyridines) Based Arenes or Heteroarenes.
Authors: Elwahy Ahmed H. M. , Abdelhamid Ismail A. , Sanad Sherif M. H. , Kassab Refaie M.
Published: August 2016

The yields in the reaction of arene‐coupled dialdehydes with aminobutenenitrile are significantly higher by using microwave heating compared to conventional heating.
ChemInform Abstract: Catalytic Enantioselective Synthesis of Halocyclopropanes.
Authors: Pons Amandine , Ivashkin Pavel , Poisson Thomas , Charette Andre B. , Pannecoucke Xavier , Jubault Philippe
Published: August 2016

Cyclopropanation of 2‐haloalkenes with α‐cyano‐diazoacetates in the presence of a chiral Rh‐catalyst provides a general synthesis of highly functionalized cyclopropanes such as (III) and (V).
ChemInform Abstract: Palladium‐Catalyzed Oxidative Synthesis of α‐Acetoxylated Enones from Alkynes.
Authors: Jiang Tuo , Quan Xu , Zhu Can , Andersson Pher G. , Baeckvall Jan‐E.
Published: August 2016

The reaction shows good tolerance towards a range of functional groups.
ChemInform Abstract: Pd/C‐Catalyzed Carbonylative Esterification of Aryl Halides with Alcohols by Using Oxiranes as CO Sources.
Authors: Min Byul‐Hana , Kim Dong‐Su , Park Hyo‐Soon , Jun Chul‐Ho
Published: August 2016

A new Pd(0)‐catalyzed carbonylative esterification of aryl bromides is developed using styrene oxide as CO‐source.
ChemInform Abstract: A Highly Efficient Heterogeneous Copper‐Catalyzed Chan—Lam Coupling Reaction of Sulfonyl Azides with Arylboronic Acids Leading to N‐Arylsulfonamides.
Authors: You Chongren , Yao Fang , Yan Tao , Cai Mingzhong
Published: August 2016

The use of the novel silica supported catalyst (CUP) allows the synthesis of a wide range of N‐arylsulfonylamides at room temperature under air without the need for any base or additive.
ChemInform Abstract: Highly Stereoselective [3 + 2] Cycloadditions of Chiral Palladium‐Containing N1‐1,3‐Dipoles: A Divergent Approach to Enantioenriched Spirooxindoles.
Authors: Li Tian‐Ren , Cheng Bei‐Yi , Fan Si‐Qi , Wang Ya‐Ni , Lu Liang‐Qiu , Xiao Wen‐Jing
Published: August 2016

A catalytic asymmetric cycloaddition of 1,3‐dipoles, generated in situ by ring‐opening of aziridines, with 3‐methylene‐2‐oxindoles is developed furnishing spirooxindoles in high yields and excellent stereoselectivities.
ChemInform Abstract: Unusual Formal [1 + 4] Annulation Through Tandem P(NMe2)3‐Mediated Cyclopropanation/Base‐Catalyzed Cyclopropane Rearrangement: Facile Syntheses of Cyclopentenimines and Cyclopentenones.
Authors: Zhou Rong , Zhang Kai , Han Ling , Chen Yusong , Li Ruifeng , He Zhengjie
Published: August 2016

A formal [1+4] annulation of α‐dicarbonyl compounds with 1,1‐dicyano‐1,3‐dienes is realized, leading to facile syntheses of cyclopentenimines and cyclopentenones in a unique manner.
ChemInform Abstract: Silver‐Catalyzed 7‐exo‐dig Cyclization of Silylenolether‐ynesulfonamides.
Authors: Heinrich Clement F. , Fabre Indira , Miesch Laurence
Published: August 2016

Cyclization of silylenolether‐ynesulfonamides proceeds at ambient temperature under mild reaction conditions under silver catalysis.
ChemInform Abstract: Studies on the Enantioselective Kinugasa Reaction: Efficient Synthesis of β‐Lactams Catalyzed by N‐PINAP/CuX Complexes.
Authors: Wolosewicz Karol , Michalak Michal , Adamek Jakub , Furman Bartlomiej
Published: August 2016

Noteworthy, the Cu salt is shown to have big influence on the enantioselectivity of the Kinugasa reaction in the presence of N‐PINAP ligands.
ChemInform Abstract: Direct Oxidative Lactonization of Alkenoic Acids Mediated Solely by NaIO4: Beyond a Simple Oxidant.
Authors: Kang Yan‐Biao , Chen Xian‐Min , Yao Chuan‐Zhi , Ning Xiao‐Shan
Published: August 2016

NaIO4 works not only as an oxidant.
ChemInform Abstract: Positional Selectivity in C—H Functionalizations of 2‐Benzylfurans with Bimetallic Catalysts.
Authors: Zhang Jiadi , Sha Sheng‐Chun , Bellomo Ana , Trongsiriwat Nisalak , Gao Feng , Tomson Neil C. , Walsh Patrick J.
Published: August 2016

Bimetallic catalysts, generated in situ from Pd(O—Ac)2, the ligand and a base, exert a high degree of control in site‐selective arylation reactions of both sp2 and sp3 C—H bonds in 2‐benzylfurans.
ChemInform Abstract: Desilylation‐Activated Propargylic Transformation: Enantioselective Copper‐Catalyzed [3 + 2] Cycloaddition of Propargylic Esters with β‐Naphthol or Phenol Derivatives.
Authors: Shao Long , Wang Ya‐Hui , Zhang De‐Yang , Xu Jie , Hu Xiang‐Ping
Published: August 2016

A copper‐catalyzed asymmetric [3+2] cycloaddition of 3‐trimethylsilylpropargylic esters with either β‐naphthols or electron‐rich phenols is realized and proceeds by a desilylation‐activated process.
ChemInform Abstract: Three‐Component 2‐Aryl Substituted Benzothiophene Formation under Transition‐Metal Free Conditions.
Authors: Jiang Pengcheng , Che Xingzong , Liao Yunfeng , Huang Huawen , Deng Guo‐Jun
Published: August 2016

In this novel approach to 2‐arylbenzothiophenes, esters and 2‐halobenzaldehydes are applied as reactants together with elemental sulfur.
ChemInform Abstract: Rhodium‐Catalyzed Enantioselective Arylation of N‐Substituted α,β‐Unsaturated γ‐Lactams: Preparation of Chiral 4‐Aryl‐2‐pyrrolidones.
Authors: Fang Jo‐Hsuan , Chang Chiung‐An , Gopula Balraj , Kuo Ting‐Shen , Wu Ping‐Yu , Henschke Julian P. , Wu Hsyueh‐Liang
Published: August 2016

A highly stereoselective conjugate addition of arylboronic acids and N‐substituted α,β‐unsaturated γ‐lactams provides the chiral title pyrrolidones.
ChemInform Abstract: Efficient Synthesis of Indole Derivatives via Tandem Cyclization Catalyzed by Magnetically Recoverable Palladium/Magnetite (Pd‐Fe3O4) Nanocrystals.
Authors: Kwon Jungmin , Chung Jooyoung , Byun Sangmoon , Kim B. Moon
Published: August 2016

A Sonogashira coupling reaction of 2‐haloanilines and alkynes followed by tandem cyclization affords the title indoles.
ChemInform Abstract: Rh(III)‐Catalyzed Chemoselective C—H Functionalizations of Tertiary Aniline N‐Oxides with Alkynes.
Authors: Huang Xiaolei , Liang Wenbo , Shi Yang , You Jingsong
Published: August 2016

In the case of aniline oxides (XI) with strong electron‐withdrawing groups and cyclic aniline N‐oxides (XIII) diphenylacetylene adds regioselectively in the ortho‐position accompanied by an O‐atom transfer.
ChemInform Abstract: Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C—H Bonds.
Authors: Liu Cong , Zhang Qi , Li Hongbo , Guo Shuangxi , Xiao Bin , Deng Wei , Liu Lei , He Wei
Published: August 2016

An oxidative cyclization of o‐alkyl substituted benzoic acids through a Ritter‐type reaction with acetonitrile is described to provide N‐acetyl substituted lactams in moderate to good yields.
ChemInform Abstract: Catalyst‐Free Three‐Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer‐Type Rearrangement.
Authors: Wang Peng‐Min , Pu Fan , Liu Ke‐Yan , Li Chao‐Jun , Liu Zhong‐Wen , Shi Xian‐Ying , Fan Juan , Yang Ming‐Yu , Wei Jun‐Fa
Published: August 2016

A catalyst free three‐component reaction of 3,4,5‐trimethoxybenzoic acid with sulfonamides or carboxylic amides and DMSO as methylene source proceeds through a Pummerer‐type rearrangement to provide a convenient access to N‐substituted isoindolinones.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Multicomponent Synthesis of Functionalized Benzimidazothiazoles
Authors: Veltri Lucia , Grasso Giuseppe , Rizzi Rosanna , Mancuso Raffaella , Gabriele Bartolo
Published: August 2016

by domino oxidative aminocarbonylation/heterocyclization of propynylthiobenzimidazolium bromides with various amines and CO
ChemInform Abstract: Copper‐II Mediated Tandem Reaction Between Aromatic Ketones and 2‐Aminobenzenethiol for the Synthesis of 2‐Aroylbenzothiazoles.
Authors: Mali Jaishree K. , Mali Devidas A. , Telvekar Vikas N.
Published: August 2016

A simple, mild, and efficient aerobic, Cu(II)‐mediated tandem protocol for the synthesis of 2‐aroylbenzothiazoles is developed.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Carbodiimides and Nitrilimines: Synthesis and Mechanistic Study of 5‐Amino‐1,2,4‐triazoles.
Authors: Yen Wan‐Ping , Kung Fung‐Chun , Wong Fung Fuh
Published: August 2016

1,3‐Dipolar cycloaddition of nitrilimines, generated from hydrazonoyl chlorides with carbodiimides (II) provides a novel synthesis of 5‐amino‐1,2,4‐triazoles.
ChemInform Abstract: Direct Construction of Chiral Quaternary Dihydropyranones Through Highly Enantioselective Organocatalytic hetero‐Diels—Alder Reactions of Olefinic Azlactones.
Authors: Gao Tai‐Ping , Liu Dan , Lin Jun‐Bing , Hu Xiu‐Qin , Wang Zhu‐Yin , Xu Peng‐Fei
Published: August 2016

For the first time, an enantioselective hetero‐Diels—Alder reaction of an in situ generated diene with β,γ‐unsaturated α‐keto esters or α‐keto esters is reported.
ChemInform Abstract: Antibacterial Structure—Activity Relationship Studies of Several Tricyclic Sulfur‐Containing Flavonoids.
Authors: Bahrin Lucian G , Hopf Henning , Jones Peter G , Sarbu Laura G , Babii Cornelia , Mihai Alina C , Stefan Marius , Birsa Lucian M
Published: August 2016

The title compounds (IV) are prepared by cyclocondensation of 3‐dithiocarbamic flavones (III) and (VI).
ChemInform Abstract: An Efficient One‐Pot Regioselective Approach Towards the Synthesis of Thiopyrano[2,3‐d]thiazole‐2‐thiones Catalyzed by Basic Ionic Liquid under Microwave Irradiation.
Authors: Siddiqui I. R. , Srivastava Arjita , Shamim Shayna , Srivastava Anjali , Shireen Anjali , Waseem Malik A.
Published: August 2016

A green method for preparation of the title thiopyran derivatives by cyclocondensation of (thioxo)thiazolidinone, benzaldehydes, and β‐oxodithioesters using ionic liquid as catalyst and solvent is developed.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Four‐Component Synthesis of Thiochromenones: The Advantages of a Reagent Capsule.
Authors: Shen Chaoren , Spannenberg Anke , Wu Xiao‐Feng
Published: August 2016

The use of paraffin wax‐encapsulated Na2S·9H2O provides a straightforward access to synthetically valuable thiochromenone derivatives by a palladium‐catalyzed carbonylative four‐component reaction.
ChemInform Abstract: Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates.
Authors: Zhang Enxuan , Tang Jiaze , Li Suhua , Wu Peng , Moses John E. , Sharpless K. Barry
Published: August 2016

A selection of heteroaryl fluorosulfates is synthesized using commercial SO2F2 gas.
ChemInform Abstract: Cooperative Lewis Acid/Cp*CoIII Catalyzed C—H Bond Activation for the Synthesis of Isoquinolin‐3‐ones.
Authors: Kim Ju Hyun , Gressies Steffen , Glorius Frank
Published: August 2016

Based on a Co(III)‐catalyzed C—H activation of imines such as (I), the reaction with diazo compounds offers a convenient method for the synthesis of isoquinolin‐3‐ones.
ChemInform Abstract: A Catalyst‐Free, One‐Pot Multicomponent Synthesis of Spiro‐Benzimidazoquinazolinones via a Knoevenagel—Michael‐Imine Pathway: A Microwave Assisted Approach.
Authors: Maloo Preeti , Roy Tapta Kanchan , Sawant Devesh M. , Pardasani Ram T. , Salunkhe Manikrao M.
Published: August 2016

In this novel three‐component approach, the title compounds are simply prepared by short microwave‐heating.
ChemInform Abstract: ortho‐Functionalized Aryltetrazines by Direct Palladium‐Catalyzed C—H Halogenation: Application to Fast Electrophilic Fluorination Reactions.
Authors: Testa Christelle , Gigot Elodie , Genc Semra , Decreau Richard , Roger Julien , Hierso Jean‐Cyrille
Published: August 2016

Reaction conditions are developed for ortho‐selective Pd‐catalyzed C—H functionalization of biphenyl‐1,2,4,5‐tetrazine.
ChemInform Abstract: Enantioselective Synthesis of Silacyclopentanes.
Authors: Igawa Kazunobu , Yoshihiro Daisuke , Abe Yusuke , Tomooka Katsuhiko
Published: August 2016

Functionalized silacyclopentanes are synthesized by enantioselective β‐elimination of silacyclopentene oxides and subsequent stereospecific transformations using a newly developed chiral lithium amide.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of Chiral Spiro‐9‐silabifluorenes by Dehydrogenative Silylation: Mechanistic Insights into the Construction of Tetraorganosilicon Stereocenters.
Authors: Murai Masahito , Takeuchi Yutaro , Yamauchi Kanae , Kuninobu Yoichiro , Takai Kazuhiko
Published: August 2016

Mechanistic insight into the construction of quaternary silicon chiral centers by rhodium‐catalyzed synthesis of spiro‐9‐silabifluorenes through dehydrogenative silylation is reported.
ChemInform Abstract: Nickel‐Catalyzed Phosphorylation of Phenol Derivatives via C—O/P—H Cross‐Coupling.
Authors: Yang Jia , Xiao Jing , Chen Tieqiao , Han Li‐Biao
Published: August 2016

Both H‐phosphonates and secondary phosphine oxides are suitable substrates for this Ni‐catalyzed phosphorylation of phenol derivatives.
ChemInform Abstract: Sporulaminals A and B: A Pair of Unusual Epimeric Spiroaminal Derivatives from a Marine‐Derived Fungus Paraconiothyrium sporulosum YK‐03.
Authors: Zhang Li‐Hua , Feng Bao‐Min , Chen Gang , Li Sheng‐Ge , Sun Yi , Wu Hong‐Hua , Bai Jiao , Hua Hui‐Ming , Wang Hai‐Feng , Pei Yue‐Hu
Published: August 2016

C‐4 epimeric sporulaminals A (I) and B (II) are the first representatives of spiroaminals with a 6/4/5/5 tetracyclic ring system derived from bergamotane sesquiterpenoid.
ChemInform Abstract: Microwave‐Assisted Rapid Enzymatic Synthesis of Nucleic Acids.
Authors: Hari Das Rakha , Ahirwar Rajesh , Kumar Saroj , Nahar Pradip
Published: August 2016

The microwave‐induced enhancement of reactions catalyzed by Escherichia coli DNA polymerase I and avian myeloblastosis virus‐reverse transcriptase is reported.
ChemInform Abstract: Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates.
Authors: Cantley Alexandra M. , Woznica Arielle , Beemelmanns Christine , King Nicole , Clardy Jon
Published: August 2016

An atypical sulfonolipid (I) with rare syn‐diol configuration that inhibits the conversion from unicellular to a multicellular morphology in choanoflagellates is isolated.
ChemInform Abstract: A New Isoflavanol from the Fruits of Kotschya strigosa (Fabaceae).
Authors: Awouafack Maurice D. , Tchuenguem Roland T. , Ito Takuya , Dzoyem Jean P. , Tane Pierre , Morita Hiroyuki
Published: August 2016

The isolation of the new isoflavanol named kotstrigoisoflavanol (I) together with three known compounds, is achieved by phytochemical investigation of the fruits of Kotschya strigosa (Fabaceae).
ChemInform Abstract: Antiinflammatory Prenylated Flavonoids from Helminthostachys zeylanica.
Authors: Su Li‐Hua , Li Yan‐Ping , Li Hong‐Mei , Dai Wei‐Feng , Liu Dan , Cao Lang , Li Rong‐Tao
Published: August 2016

Two new prenylated flavonoids, neougonins A (I) and B (II), are isolated from the whole plant of Helminthostachys zeylanica along with nine known compounds.
ChemInform Abstract: Enantioselective Construction of Chiral 2,3‐cis‐Dimethyldihydrobenzofuran with an All‐Carbon Quaternary Center: An Efficient Approach to (+)/(‐)‐PI‐220 and (+)‐3‐epi‐Furaquinocin C.
Authors: Pu Liu‐Yang , Chen Ji‐Qiang , Li Mao‐Lin , Li Yao , Xie Jian‐Hua , Zhou Qi‐Lin
Published: August 2016

Total syntheses of the title compounds establishes the absolute configuration of naturally occurring PI‐220 as (2S,3R).
ChemInform Abstract: Water at Interfaces
Authors: Bjoerneholm Olle , Hansen Martin H. , Hodgson Andrew , Liu Li‐Min , Limmer David T. , Michaelides Angelos , Pedevilla Philipp , Rossmeisl Jan , Shen Huaze , Tocci Gabriele , et al.
Published: August 2016

Review: 306 refs.
ChemInform Abstract: Halide Perovskites: Poor Man′s High‐Performance Semiconductors
Authors: Stoumpos Constantinos C. , Kanatzidis Mercouri G.
Published: August 2016

Review: [145 refs.
ChemInform Abstract: Iron‐Based Magnetic Nanomaterials and Their Environmental Applications
Authors: Zhou Qingxiang , Li Jing , Wang Mengyun , Zhao Danchen
Published: August 2016

Review: 191 refs.
ChemInform Abstract: Coordination Polymers Built from 1,4‐Bis(imidazol‐1‐ylmethyl)benzene: from Crystalline to Amorphous
Authors: Adarsh N. N. , Novio Fernando , Ruiz‐Molina Daniel
Published: August 2016

Review: 85 refs.
ChemInform Abstract: Organophosphines in Organoplatinum Complexes ‐ Structural Aspects of Trans‐PtP2CCl Derivatives
Authors: Melnik Milan , Mikus Peter
Published: August 2016

Review: 111 refs.
ChemInform Abstract: Photochemical Synthesis of Azaheterocycles
Authors: Tanoury Gerald J.
Published: August 2016

Review: [66 refs.
ChemInform Abstract: Small Ring Compounds and N‐Oxides: Cycloadditions and Related Processes
Authors: Tabolin Andrey A. , Ioffe Sema L.
Published: August 2016

Review: [93 refs.
ChemInform Abstract: Synthetic Applications and Methodological Developments of Donor—Acceptor Cyclopropanes and Related Compounds
Authors: O'Connor Nicholas R. , Wood John L. , Stoltz Brian M.
Published: August 2016

Review: [55 refs.
ChemInform Abstract: Synthetic Applications of Aroyl‐ and Nitro‐Substituted 2‐Aryl‐cyclopropane‐1,1‐dicarboxylates
Authors: Selvi Thangavel , Srinivasan Kannupal
Published: August 2016

Review: [32 refs.
ChemInform Abstract: Synthesis of Multisubstituted Silyloxy‐Based Donor—Acceptor Cyclobutanes by an Acid‐Catalyzed [2 + 2] Cycloaddition
Authors: Takasu Kiyosei
Published: August 2016

Review: [33 refs.
ChemInform Abstract: The Catalytic, Formal Homo‐Nazarov Cyclization as a Template for Diversity‐Oriented Synthesis
Authors: Martin M. Cynthia , Shenje Raynold , France Stefan
Published: August 2016

Review: [46 refs.
ChemInform Abstract: Azadipyrromethenes: From Traditional Dye Chemistry to Leading Edge Applications
Authors: Ge Yuan , O'Shea Donal F.
Published: August 2016

Review: 169 refs.
ChemInform Abstract: Nitrogenases—A Tale of Carbon Atom(s)
Authors: Hu Yilin , Ribbe Markus W.
Published: August 2016

Review: 58 refs.
ChemInform Abstract: Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)
Authors: Sancar Aziz
Published: August 2016

Review: 179 refs.
ChemInform Abstract: Germanium‐Based Nanomaterials for Rechargeable Batteries
Authors: Wu Songping , Han Cuiping , Iocozzia James , Lu Mingjia , Ge Rongyun , Xu Rui , Lin Zhiqun
Published: August 2016

Review: 229 refs.
ChemInform Abstract: Paving the Way for Lignin Valorisation: Recent Advances in Bioengineering, Biorefining and Catalysis
Authors: Rinaldi Roberto , Jastrzebski Robin , Clough Matthew T. , Ralph John , Kennema Marco , Bruijnincx Pieter C. A. , Weckhuysen Bert M.
Published: August 2016

Review: 427 refs.
Single‐Molecule Fluorescence Detection of a Synthetic Heparan Sulfate Disaccharide
Authors: Dalton Charlotte E. , Quinn Steven D. , Rafferty Aidan , Morten Michael J. , Gardiner John M. , Magennis Steven W.
Published: August 2016

The first single‐molecule fluorescence detection of a structurally‐defined synthetic carbohydrate is reported: a heparan sulfate (HS) disaccharide fragment labeled with Alexa488. Single molecules have been measured whilst freely diffusing in solution and controlled encapsulation in surface‐tethered lipid vesicles has allowed extended observations of carbohydrate molecules down to the single‐molecule level. The diverse and dynamic nature of HS–protein interactions means that new tools to investigate pure HS fragments at the molecular level would significantly enhance our understanding of HS. This work is a proof‐of‐principle demonstration of the feasibility of single‐molecule studies of synthetic carbohydrates which offers a new approach to the study of pure glycosaminoglycan (GAG) fragments.
Cytologic features of papillary tumor of the pineal region: A case report showing tigroid background
Authors: Jiménez‐Heffernan José A. , Bárcena Carmen , Gordillo Carlos , Cañizal José M.
Published: August 2016

Papillary tumor of the pineal region (PTPR) is a rare neuroepithelial tumor of the pineal region of adults. We herein describe on a 34‐year‐old female the cytologic features of a PTPR studied using Diff‐Quik stain. The patient presented hydrocephalia secondary to a pineal tumor. During surgery an intraoperative pathologic consultation was requested. Smears were hypercellular with numerous papillary tissue fragments and single cells. Papillary fragments had an evident inner vascular core. Neoplastic cells displayed moderate pleomorphism, plasmocytoid morphology, and cytoplasmic fragility. The background had a foamy, lace‐like, tigroid appearance. Pathologic analysis revealed morphologic and immunohistochemical features of PTPR. When evaluating smears of a pineal tumor in an adult, the presence of true papillary structures and numerous single cells should raise the possibility of PTPR. This is particularly useful during intraoperative pathologic evaluation since, on frozen sections, the epithelial morphology of the tumor may be misleading. The papillary morphology which gives name to this neoplams is best appreciated on squash smears. An interesting feature seen in the present case was a prominent tigroid background. This is a characteristic cytologic feature observed in Romanowsky‐type stained smears of germinoma and related tumors. It can be seen in other clear cell, glycogen‐rich tumors. PTPR shares with these neoplasms its clear cell morphology and PAS positive cytoplasmic granules. As seen from the present case, germinoma is not the only tumor of the pineal region that may show a tigroid background. Cytologic features of PTPR differ from those of germinoma allowing their distinction during intraoperative consultations. Diagn. Cytopathol. 2016;44:1098–1101. © 2016 Wiley Periodicals, Inc.
Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress‐Induced Damage via Induction of Nrf‐2‐Mediated HO‐1 Expression
Authors: Choi Yung Hyun
Published: August 2016

Preclinical Research

The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2O2)‐induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO‐1 pathway. BBH preconditioning attenuated H2O2‐induced growth inhibition and DNA damage as well as apoptosis in C2C12 cells via suppression of the accumulation of intracellular reactive oxygen species (ROS). Treatment with BBHride alone effectively upregulated the expression of nuclear factor‐erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1) and elevated HO‐1 activity. However, the protective effects of BBH against H2O2‐induced ROS generation and cell growth reduction were abolished by an HO‐1 inhibitor. Moreover, BBH‐mediated induction and activation of HO‐1 were reduced by genetic silencing of Nrf2 using small interfering RNA (siRNA). In addition, the effects of BBH against H2O2‐induced ROS accumulation and growth inhibition were abrogated in C2C12 cells transfected with Nrf2 siRNA. Therefore, the present study demonstrated that BBH could protect C2C12 cells against oxidative stress‐induced injury and this effect involved activation of the Nrf2/HO‐1 pathway. Drug Dev Res, 2016. © 2016 Wiley Periodicals, Inc.
Resource partitioning between ungulate populations in arid environments
Authors: Cooke Robert S. C. , Woodfine Tim , Petretto Marie , Ezard Thomas H. G.
Published: August 2016

Herbivores are major drivers of ecosystem structure, diversity, and function. Resilient ecosystems therefore require viable herbivore populations in a sustainable balance with environmental resource availability. This balance is becoming harder to achieve, with increasingly threatened species reliant on small protected areas in increasingly harsh and unpredictable environments. Arid environments in North Africa exemplify this situation, featuring a biologically distinct species assemblage exposed to extreme and volatile conditions, including habitat loss and climate change‐associated threats. Here, we implement an integrated likelihood approach to relate scimitar‐horned oryx (Oryx dammah) and dorcas gazelle (Gazella dorcas) density, via dung distance sampling, to habitat, predator, and geographic correlates in Dghoumes National Park, Tunisia. We show how two threatened sympatric ungulates partition resources on the habitat axis, exhibiting nonuniform responses to the same vegetation gradient. Scimitar‐horned oryx were positively associated with plant species richness, selecting for vegetated ephemeral watercourses (wadis) dominated by herbaceous cover. Conversely, dorcas gazelle were negatively associated with vegetation density (herbaceous height, litter cover, and herbaceous cover), selecting instead for rocky plains with sparse vegetation. We suggest that adequate plant species richness should be a prerequisite for areas proposed for future ungulate reintroductions in arid and semi‐arid environments. This evidence will inform adaptive management of reintroduced ungulates in protected environments, helping managers and planners design sustainable ecosystems and effective conservation programs.