bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of population stratification on genetic markers associated with type 1 diabetes
Authors: Gomes Karla Fabiana Brasil , Santos Aritânia Sousa , Semzezem Cintia , Correia Márcia Regina , Brito Luciano Abreu , Ruiz Marcelo Ortega , Fukui Rosa Tsuneshiro , Matioli Sergio Russo , Passos-Bueno Maria Rita , Silva Maria Elizabeth Rossi da
Published: March 2017

Ethnic admixtures may interfere with the definition of type 1 diabetes (T1D) risk determinants. The role of HLA, PTPN22, INS-VNTR, and CTLA4 in T1D predisposition was analyzed in Brazilian T1D patients (n = 915), with 81.7% self-reporting as white and 789 controls (65.6% white). The results were corrected for population stratification by genotyping 93 ancestry informative markers (AIMs) (BeadXpress platform). Ancestry composition and structural association were characterized using Structure 2.3 and STRAT. Ethnic diversity resulted in T1D determinants that were partially discordant from those reported in Caucasians and Africans. The greatest contributor to T1D was the HLA-DR3/DR4 genotype (OR = 16.5) in 23.9% of the patients, followed by -DR3/DR3 (OR = 8.9) in 8.7%, -DR4/DR4 (OR = 4.7) in 6.0% and -DR3/DR9 (OR = 4.9) in 2.6%. Correction by ancestry also confirmed that the DRB1*09-DQB1*0202 haplotype conferred susceptibility, whereas the DRB1*07-DQB1*0202 and DRB1*11-DQB1*0602 haplotypes were protective, which is similar to reports in African-American patients. By contrast, the DRB1*07-DQB1*0201 haplotype was protective in our population and in Europeans, despite conferring susceptibility to Africans. The DRB1*10-DQB1*0501 haplotype was only protective in the Brazilian population. Predisposition to T1D conferred by PTPN22 and INS-VNTR and protection against T1D conferred by the DRB1*16 allele were confirmed. Correcting for population structure is important to clarify the particular genetic variants that confer susceptibility/protection for T1D in populations with ethnic admixtures.
Functional annotation of sixty-five type-2 diabetes risk SNPs and its application in risk prediction
Authors: Wu Yiming , Jing Runyu , Dong Yongcheng , Kuang Qifan , Li Yan , Huang Ziyan , Gan Wei , Xue Yue , Li Yizhou , Li Menglong
Published: March 2017

Genome-wide association studies (GWAS) have identified more than sixty single nucleotide polymorphisms (SNPs) associated with increased risk for type 2 diabetes (T2D). However, the identification of causal risk SNPs for T2D pathogenesis was complicated by the factor that each risk SNP is a surrogate for the hundreds of SNPs, most of which reside in non-coding regions. Here we provide a comprehensive annotation of 65 known T2D related SNPs and inspect putative functional SNPs probably causing protein dysfunction, response element disruptions of known transcription factors related to T2D genes and regulatory response element disruption of four histone marks in pancreas and pancreas islet. In new identified risk SNPs, some of them were reported as T2D related SNPs in recent studies. Further, we found that accumulation of modest effects of single sites markedly enhanced the risk prediction based on 1989 T2D samples and 3000 healthy controls. The AROCvalue increased from 0.58 to 0.62 by only using genotype score when putative risk SNPs were added. Besides, the net reclassification improvement is 10.03% on the addition of new risk SNPs. Taken together, functional annotation could provide a list of prioritized potential risk SNPs for the further estimation on the T2D susceptibility of individuals.
Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease
Authors: Ueno Kentaro , Ninomiya Yumiko , Hazeki Daisuke , Masuda Kiminori , Nomura Yuichi , Kawano Yoshifumi
Published: March 2017

Disruption of endothelial cell homeostasis may be associated with the pathogenesis of coronary artery abnormalities (CAA) in Kawasaki disease (KD). We sought to clarify the poorly understood pathogenic role of endothelial cell survival and death in KD vasculitis. Human umbilical vein endothelial cells (HUVECs) stimulated with sera from KD patients, compared with sera from patients with bacterial infections, exhibited significant increases in cytotoxicity, high mobility group box protein 1 (HMGB-1), and caspase-3/7 and a decrease in phosphorylated Akt/Akt (pAkt/Akt) ratios. HUVECs stimulated with sera from KD patients treated with immunoglobulin (IG) showed significantly decreased cytotoxicity, HMGB-1, and caspase-3/7 levels and increased pAkt/Akt ratios, as compared with results for untreated HUVECs (P < 0.001, P = 0.008, P = 0.040, and P < 0.001, respectively). In HUVECs stimulated with sera from KD patients, the increased cytotoxicity levels and the suppression of increased pAkt/Akt ratios after subsequent IG treatment were closely related to the development of CAA (P = 0.002 and P = 0.035). Our data reveal that shifting the balance toward cell death rather than survival appears to perturb endothelial cell homeostasis and is closely related to the development of CAA. The cytoprotective effects of IG treatment appear to ameliorate endothelial cell homeostasis.
Fundamental limits of ultrathin metasurfaces
Authors: Arbabi Amir , Faraon Andrei
Published: March 2017

We present a set of universal relations which relate the local transmission, reflection, and polarization conversion coefficients of a general class of non-magnetic passive ultrathin metasurfaces. We show that these relations are a result of equal forward and backward scattering by single layer ultrathin metasurfaces, and they lead to confinement of the transmission, reflection, and polarization conversion coefficients to limited regions of the complex plane. Using these relations, we investigate the effect of the presence of a substrate, and show that the maximum polarization conversion efficiency for a transmissive metasurface decreases as the refractive index contrast between the substrate and cladding layer increases. Furthermore, we demonstrate that a single layer reflective metasurface can achieve full 2π phase shift coverage without altering the polarization if it is illuminated from the higher refractive index material. We also discuss two approaches for achieving asymmetric scattering from metasurfaces, and realizing metasurfaces which overcome the performance limitations of single layer ultrathin metasurfaces.
Urodynamic prognostic factors for large post-void residual urine volume after intravesical injection of onabotulinumtoxinA for overactive bladder
Authors: Hsiao Sheng-Mou , Lin Ho-Hsiung , Kuo Hann-Chorng
Published: March 2017

The aim of this study was to identify factors predicting large post-void residual (PVR) (defined as ≥200 mL), an important unsolved problem, after an intravesical injection of onabotulinumtoxinA in patients with overactive bladder syndrome. The data showed that 133 of 290 patients had a large PVR after treatment. Multivariate analysis found that the baseline 3-day daytime frequency episodes and voiding efficiency were independent predictors for postoperative large PVR. A receiver operating characteristic (ROC) curve analysis showed the following optimum cut-off values: (1) 3-day daytime frequency episodes = 25, which has a ROC area of 0.72; and (2) voiding efficiency = 89%, which has a ROC area being 0.66. The predicted logit transformation of probability of large PVR, logit(p), for a given 3-day daytime frequency episodes (a) and voiding efficiency (b%) can be denoted by logit(p) = −5.18 + 0.07 × a + 0.04 × b, with a cutoff value of logit(p) = 0.34 and a ROC area of 0.79. The median value of the persistent large PVR interval was 5 months. In conclusion, low 3-day daytime frequency episodes (<25) and low voiding efficiency (<89%) are associated with large PVR. Besides, logit(p) <0.34 can be used to predict large PVR for its higher ROC area.
Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons
Authors: Lee Philip R. , Cohen Jonathan E. , Iacobas Dumitru A. , Iacobas Sanda , Fields R. Douglas
Published: March 2017

Gene regulatory networks underlie the long-term changes in cell specification, growth of synaptic connections, and adaptation that occur throughout neonatal and postnatal life. Here we show that the transcriptional response in neurons is exquisitely sensitive to the temporal nature of action potential firing patterns. Neurons were electrically stimulated with the same number of action potentials, but with different inter-burst intervals. We found that these subtle alterations in the timing of action potential firing differentially regulates hundreds of genes, across many functional categories, through the activation or repression of distinct transcriptional networks. Our results demonstrate that the transcriptional response in neurons to environmental stimuli, coded in the pattern of action potential firing, can be very sensitive to the temporal nature of action potential delivery rather than the intensity of stimulation or the total number of action potentials delivered. These data identify temporal kinetics of action potential firing as critical components regulating intracellular signalling pathways and gene expression in neurons to extracellular cues during early development and throughout life.
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes
Authors: Khan Nazir M. , Haseeb Abdul , Ansari Mohammad Y. , Haqqi Tariq M.
Published: March 2017

Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation and sustained oxidative stress. The root extract of Scutellaria baicalensis (SBE) has been used for the treatment of inflammatory and other diseases. Here, we performed activity-guided HPLC-fractionation of SBE, identified the active ingredient(s) and investigated its chondroprotective potential. We found that the Wogonin containing fraction-4 (F4) was the most potent fraction based on its ability to inhibit ROS production and the suppression of catabolic markers including IL-6, COX-2, iNOS, MMP-3, MMP-9, MMP-13 and ADAMTS-4 in IL-1β-treated OA chondrocytes. OA chondrocytes treated with F4 in the presence of IL-1β showed significantly enhanced expression of anabolic genes ACAN and COL2A1. In an in vitro model of cartilage degradation treatment with F4 inhibited s-GAG release from IL-1β-treated human cartilage explants. The inhibitory effect of F4 was not mediated through the inhibition of MAPKs and NF-κB activation but was mediated through the suppression of c-Fos/AP-1 activity at transcriptional and post transcriptional levels in OA chondrocytes. Purified Wogonin mimicked the effects of F4 in IL-1β-stimulated OA chondrocytes. Our data demonstrates that a Wogonin-rich fraction of SBE exert chondroprotective effects through the suppression of c-Fos/AP-1 expression and activity in OA chondrocytes under pathological conditions.
SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
Authors: Guo Chun , Wilkinson Kevin A. , Evans Ashley J. , Rubin Philip P. , Henley Jeremy M.
Published: March 2017

The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell death during reperfusion after ischaemia by enhancing Drp1 partitioning to the mitochondrial outer membrane (MOM), which causes cytochrome c release and apoptosis. However, how deSUMOylation recruits Drp1 to the MOM is unknown. Here we show that deSUMOylation selectively promotes Drp1 binding to the MOM resident adaptor protein mitochondrial fission factor (Mff). Consistent with this, preventing Drp1 SUMOylation by mutating the SUMO acceptor sites enhances binding to Mff. Conversely, increasing Drp1 SUMOylation by knocking down SENP3 reduces both Drp1 binding to Mff and stress-induced cytochrome c release. Directly tethering Drp1 to the MOM bypasses the need for Mff to evoke cytochrome c release, and occludes the effect of SENP3 overexpression. Thus, Drp1 deSUMOylation promotes cell death by enhancing Mff-mediated mitochondrial recruitment. These data provide a mechanistic explanation for how the SUMOylation status of Drp1 acts as a key switch in cell death/survival decisions following extreme cell stress.
IL-6 ameliorates acute lung injury in influenza virus infection
Authors: Yang Mei-Lin , Wang Chung-Teng , Yang Shiu-Ju , Leu Chia-Hsing , Chen Shun-Hua , Wu Chao-Liang , Shiau Ai-Li
Published: March 2017

Interleukin 6 (IL-6) is involved in innate and adaptive immune responses to defend against pathogens. It also participates in the process of influenza infection by affecting viral clearance and immune cell responses. However, whether IL-6 impacts lung repair in influenza pathogenesis remains unclear. Here, we studied the role of IL-6 in acute influenza infection in mice. IL-6-deficient mice infected with influenza virus exhibited higher lethality, lost more body weight and had higher fibroblast accumulation and lower extracellular matrix (ECM) turnover in the lung than their wild-type counterparts. Deficiency in IL-6 enhanced proliferation, migration and survival of lung fibroblasts, as well as increased virus-induced apoptosis of lung epithelial cells. IL-6-deficient lung fibroblasts produced elevated levels of TGF-β, which may contribute to their survival. Furthermore, macrophage recruitment to the lung and phagocytic activities of macrophages during influenza infection were reduced in IL-6-deficient mice. Collectively, our results indicate that IL-6 is crucial for lung repair after influenza-induced lung injury through reducing fibroblast accumulation, promoting epithelial cell survival, increasing macrophage recruitment to the lung and enhancing phagocytosis of viruses by macrophages. This study suggests that IL-6 may be exploited for lung repair during influenza infection.
Study on the noncoincidence effect phenomenon using matrix isolated Raman spectra and the proposed structural organization model of acetone in condense phase
Authors: Xu Wenwen , Wu Fengqi , Zhao Yanying , Zhou Ran , Wang Huigang , Zheng Xuming , Ni Bukuo
Published: March 2017

The isotropic and anisotropic Raman spectra of acetone and deuterated acetone isolated in an argon matrix have been recorded for the understanding of noncoincidence effect (NCE) phenomenon. According to the matrix isolated Raman spectra and DFT calculations, we proposed aggregated model for the explanations of the acetone C=O vibration NCE phenomenon and its concentration effect. The experimental data were in consistence with the DFT calculations performed at the B3LYP-D3/6-311 G (d,p) levels based on the proposed model. The experimental identification of the monomer, dimer and trimer are reported here, and the dynamic of the transformation from monomer to aggregated structure can be easily controlled by tuning annealing temperature.
Multifork chromosome replication in slow-growing bacteria
Authors: Trojanowski Damian , Hołówka Joanna , Ginda Katarzyna , Jakimowicz Dagmara , Zakrzewska-Czerwińska Jolanta
Published: March 2017

The growth rates of bacteria must be coordinated with major cell cycle events, including chromosome replication. When the doubling time (Td) is shorter than the duration of chromosome replication (C period), a new round of replication begins before the previous round terminates. Thus, newborn cells inherit partially duplicated chromosomes. This phenomenon, which is termed multifork replication, occurs among fast-growing bacteria such as Escherichia coli and Bacillus subtilis. In contrast, it was historically believed that slow-growing bacteria (including mycobacteria) do not reinitiate chromosome replication until the previous round has been completed. Here, we use single-cell time-lapse analyses to reveal that mycobacterial cell populations exhibit heterogeneity in their DNA replication dynamics. In addition to cells with non-overlapping replication rounds, we observed cells in which the next replication round was initiated before completion of the previous replication round. We speculate that this heterogeneity may reflect a relaxation of cell cycle checkpoints, possibly increasing the ability of slow-growing mycobacteria to adapt to environmental conditions.
A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations
Authors: Giddey Alexander D. , de Kock Elise , Nakedi Kehilwe C. , Garnett Shaun , Nel Andrew J. M. , Soares Nelson C. , Blackburn Jonathan M.
Published: March 2017

In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics to investigate the temporal effects of sub-lethal concentrations of rifampicin on the mycobacterial proteome at time-points corresponding to early response, onset of bacteriostasis and early recovery. Across 18 samples, a total of 3,218 proteins were identified from 31,846 distinct peptides averaging 16,250 identified peptides per sample. We found evidence that two component signal transduction systems (e.g. MprA/MprB) play a major role during initial mycobacterial adaptive responses to sub-lethal rifampicin and that, after dampening an initial SOS response, the bacteria supress the DevR (DosR) regulon and also upregulate their transcriptional and translational machineries. Furthermore, we found a co-ordinated dysregulation in haeme and mycobactin synthesis. Finally, gradual upregulation of the M. smegmatis-specific rifampin ADP-ribosyl transferase was observed which, together with upregulation of transcriptional and translational machinery, likely explains recovery of normal growth. Overall, our data indicates that in mycobacteria, sub-lethal rifampicin triggers a concerted phenotypic response that contrasts significantly with that observed at higher antimicrobial doses.
Knockdown of the MAPK p38 pathway increases the susceptibility of Chilo suppressalis larvae to Bacillus thuringiensis Cry1Ca toxin
Authors: Qiu Lin , Fan Jinxing , Liu Lang , Zhang Boyao , Wang Xiaoping , Lei Chaoliang , Lin Yongjun , Ma Weihua
Published: March 2017

The bacterium Bacillus thuringiensis (Bt) produces a wide range of toxins that are effective against a number of insect pests. Identifying the mechanisms responsible for resistance to Bt toxin will improve both our ability to control important insect pests and our understanding of bacterial toxicology. In this study, we investigated the role of MAPK pathways in resistance against Cry1Ca toxin in Chilo suppressalis, an important lepidopteran pest of rice crops. We first cloned the full-length of C. suppressalis mitogen-activated protein kinase (MAPK) p38, ERK1, and ERK2, and a partial sequence of JNK (hereafter Csp38, CsERK1, CsERK2 and CsJNK). We could then measure the up-regulation of these MAPK genes in larvae at different times after ingestion of Cry1Ca toxin. Using RNA interference to knockdown Csp38, CsJNK, CsERK1 and CsERK2 showed that only knockdown of Csp38 significantly increased the mortality of larvae to Cry1Ca toxin ingested in either an artificial diet, or after feeding on transgenic rice expressed Cry1Ca. These results suggest that MAPK p38 is responsible for the resistance of C. suppressalis larvae to Bt Cry1Ca toxin.
Raman spectroscopy compatible PDMS droplet microfluidic culture and analysis platform towards on-chip lipidomics
Authors: Kim Hyun Soo , Waqued Sergio C. , Nodurft Dawson T. , Devarenne Timothy P. , Yakovlev Vladislav V. , Han Arum
Published: March 2017

We present a method that allows for the use of Raman spectroscopy with PDMS-based microdevices to perform on-chip, droplet-based in vivo biomolecular analysis (i.e., microalgal lipid analysis) with single-cell resolution.
Structure, electrocatalysis and dynamics of immobilized cytochrome PccH and its microperoxidase
Authors: Silveira Célia M. , Castro María A. , Dantas Joana M. , Salgueiro Carlos , Murgida Daniel H. , Todorovic Smilja
Published: March 2017

Biophysical characterization of immobilized PccH and PccH-microperoxidase reveals a higher potential of the latter for use in electrochemical H2O2 biosensors.
Hydration-controlled anisotropic and giant permittivity in TEG-functionalized eumelanin
Authors: Ambrico Marianna , Ambrico Paolo F. , Ligonzo Teresa , Cardone Antonio , Bridelli Maria Grazia , Casamassima Giuseppe , Manini Paola , d'Ischia Marco
Published: March 2017

An anisotropic and giant polarization effect in TEG-functionalized and synthetic eumelanin is related to the mode of interaction of water molecules.
Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis
Authors: Vetica Fabrizio , Chauhan Pankaj , Dochain Simon , Enders Dieter
Published: March 2017

This review describes the recent advances on the asymmetric organocatalytic synthesis of THPs and their application in total synthesis.
Structural and transport properties of neutral radical crystals of CoIII(tmp)(CN)2(tmp = 5,10,15,20-tetramethylporphyrinato) and the CN-bridged polymer [CoIII(tmp)(CN)]n
Authors: Kurokawa Masashi , Jose-Larong Judy Fe F. , Hasegawa Hiroyuki , Takahashi Yukihiro , Harada Jun , Inabe Tamotsu
Published: March 2017

Neutral radical and CN-bridged polymer crystals were obtained from an axially CN ligated Co(tmp) anion, [CoIII(tmp)(CN)2]−.
The fate and transformation of tetrabromobisphenol A in natural waters, mediated by oxidoreductase enzymes
Authors: Feng Yiping , Lu Kun , Gao Shixiang , Mao Liang
Published: March 2017

The widespread natural oxidoreductase enzymes (such as laccase and peroxidases) are able to transform tetrabromobisphenol A (TBBPA) in natural waters. The product distribution of TBBPA at low concentration (10 nmol L−1) is similar to that of TBBPA at high concentration (10 μmol L−1).
Momordica charantia: a popular health-promoting vegetable with multifunctionality
Authors: Wang Shuzhen , Li Zhiliang , Yang Guliang , Ho Chi-Tang , Li Shiming
Published: March 2017

Products derived from edible medicinal plants have been used for centuries to prevent, treat, and even cure multiple diseases.
Comparison of Leptospira interrogans and Leptospira biflexa genomes: analysis of potential leptospiral–host interactions
Authors: Mehrotra Prachi , Ramakrishnan Gayatri , Dhandapani Gunasekaran , Srinivasan Narayanaswamy , Madanan Madathiparambil G.
Published: March 2017

Comparative analyses of leptospiral–host interactions between pathogenic and non-pathogenic leptospires aided in identifying potential mechanisms of species-specific persistence and immune clearance in human hosts.
A carbon nitride supported copper nanoparticle composite: a heterogeneous catalyst for the N-arylation of hetero-aromatic compounds
Authors: Nandi Debkumar , Siwal Samarjeet , Mallick Kaushik
Published: March 2017

Copper nanoparticle catalyzed N-arylation of hetero-aromatic molecules.
Application of the aza-Diels–Alder reaction in the synthesis of natural products
Authors: Cao Min-Hui , Green Nicholas J. , Xu Sheng-Zhen
Published: March 2017

The Diels–Alder reaction that involves a nitrogen atom in the diene or dienophile is termed the aza-Diels–Alder reaction.
Retracted Article: Self-limited growth of Pr3+-doped LaF3nanocrystals in oxyfluoride glass and glass-ceramics
Authors: Mallik Amit , Barik Anil K. , Pal Biswajit
Published: March 2017

Droplets of Pr3+-doped LaF3nanocrystals in oxyfluoride glass and glass-ceramics self-limitedly grow through phase separation. The Al concentrated middle layer is sandwiched between La, F and Pr enriched inner core and Si augmented exterior shell.
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications
Authors: Gonçalves L. C. , Seabra A. B. , Pelegrino M. T. , de Araujo D. R. , Bernardes J. S. , Haddad P. S.
Published: March 2017

The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles, and their incorporation in Pluronic F127 hydrogel with great potential for topical applications.
Droplet migration on hydrophobic–hydrophilic hybrid surfaces: a lattice Boltzmann study
Authors: Li Q. , Yu Y. , Zhou P. , Yan H. J.
Published: March 2017

Droplet migration on textured hydrophobic–hydrophilic surfaces.
Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans
Authors: Hannich J. Thomas , Mellal Denia , Feng Suihan , Zumbuehl Andreas , Riezman Howard
Published: March 2017

Nematode-specific iso-branched sphingoid base synthesis: drug-target against parasites and genetic model system for human diseases.
New frontiers for mass spectrometry based upon structures for lossless ion manipulations
Authors: Ibrahim Yehia M. , Hamid Ahmed M. , Deng Liulin , Garimella Sandilya V. B. , Webb Ian K. , Baker Erin S. , Smith Richard D.
Published: March 2017

SLIM utilize manipulations in ion conduits created from electric fields generated by applying potentials to arrays of electrodes patterned on two planar surfaces.
Magnesium-ion battery-relevant electrochemistry of MgMn2O4: crystallite size effects and the notable role of electrolyte water content
Authors: Yin Jiefu , Brady Alexander B. , Takeuchi Esther S. , Marschilok Amy C. , Takeuchi Kenneth J.
Published: March 2017

MgMn2O4 nanoparticles with crystallite sizes of 11 (MMO-1) and 31 nm (MMO-2) were synthesized and their magnesium-ion battery-relevant electrochemistry was investigated.
NO-Responsive vesicles as a drug delivery system
Authors: Li Zhi-Heng , Tan Zheng-Li , Ding Ai-Xiang , Gong Bing , Lu Zhong-Lin , He Lan
Published: March 2017

A NO-response amphiphile was successfully formed into vesicles in aqueous solution, which could encapsulate and control the release of carboxyfluorescein (CF) as a model drug in vitro and in living cells.
A highly porous metal–organic framework for large organic molecule capture and chromatographic separation
Authors: Li Pei-Zhou , Su Jie , Liang Jie , Liu Jia , Zhang Yuanyuan , Chen Hongzhong , Zhao Yanli
Published: March 2017

A highly porous metal–organic framework with large pores presents large molecule based applications probed by organic dye molecules.
Understanding surface site structures and properties by first principles calculations: an experimental point of view!
Authors: Comas-Vives Aleix , Larmier Kim , Copéret Christophe
Published: March 2017

Computational Chemistry is key for the molecular-level understanding of active sites in heterogeneous catalysis paving the way to the rational design and development.
Discrete 1 : 1 complexes and higher order assemblies formed from aminobenzene sulphonate anions and a tetraimidazolium “molecular box”
Authors: Wang Cai-Ling , Zhou Li , Zhang Lei , Xiang Jun-Feng , Rambo Brett M. , Sessler Jonathan L. , Gong Han-Yuan
Published: March 2017

Aminobenzene sulphonate species having different isomeric patterns act as substrates for a tetracationic molecular box.
Spacer-controlled emission of randomly oriented fluorophores enhanced with surface plasmon-polaritons
Authors: Akimov Yu. , Sun S.
Published: March 2017

This study reveals physical insights into the spacer-controlled emission of randomly oriented emitters in the Kretschmann configuration.
Ag+-induced photoluminescence enhancement in lanthanide post-functionalized MOFs and Ag+ sensing
Authors: Sun Nana , Yan Bing
Published: March 2017

Single-phase white-light emitters based on 4d–4f heterometallic co-doped MOFs can be realized, and Sm-MIL-61 shows more highly sensitive and selective sensing towards Ag+.
Constructing accurate interaction potentials to describe the microsolvation of protonated methane by helium atoms
Authors: Kuchenbecker Dennis , Uhl Felix , Forbert Harald , Jansen Georg , Marx Dominik
Published: March 2017

An ab initio-derived interaction potential is derived and used in path integral Monte Carlo simulations to investigate stationary-point structures of CH5+ microsolvated by up to four helium atoms.
Comparison of fast electron transfer kinetics at platinum, gold, glassy carbon and diamond electrodes using Fourier-transformed AC voltammetry and scanning electrochemical microscopy
Authors: Tan Sze-yin , Lazenby Robert A. , Bano Kiran , Zhang Jie , Bond Alan M. , Macpherson Julie V. , Unwin Patrick R.
Published: March 2017

Complementary techniques reveal new insights on electron transfer rates at different electrode materials.
Controlling adsorption and passivation properties of bovine serum albumin on silica surfaces by ionic strength modulation and cross-linking
Authors: Park Jae Hyeon , Sut Tun Naw , Jackman Joshua A. , Ferhan Abdul Rahim , Yoon Bo Kyeong , Cho Nam-Joon
Published: March 2017

Understanding the physicochemical factors that influence protein adsorption onto solid supports holds wide relevance for fundamental insights into protein structure and function as well as for applications such as surface passivation.
Boron-containing MFI-type zeolites with a hierarchical nanosheet assembly for lipase immobilization
Authors: Marthala V. R. Reddy , Urmoneit Lynn , Zhou Zhou , Machoke Albert G. F. , Schmiele Martin , Unruh Tobias , Schwieger Wilhelm , Hartmann Martin
Published: March 2017

Ball-like nanosheet assemblies of boron-containing MFI-type zeolites were synthesized using bifunctional surfactant molecules. The pore size of ca. 6.5 nm allows encapsulation of the enzyme lipase.
Preparation of a uranium metallacyclocumulene and its reactivity towards unsaturated organic molecules
Authors: Zhang Lei , Hou Guohua , Zi Guofu , Ding Wanjian , Walter Marc D.
Published: March 2017

Steric and electronic properties of the coordinated ligands exert a pronounced influence on the reactivity of the uranium metallacyclocumulene complexes.
Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids
Authors: Hu Kun , Qi Linjun , Yu Shuling , Cheng Tianxing , Wang Xiaodong , Li Zhaojun , Xia Yuanzhi , Chen Jiuxi , Wu Huayue
Published: March 2017

Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids for the synthesis of diverse isoquinolines in water.
Microchip-based single-cell functional proteomics for biomedical applications
Authors: Lu Yao , Yang Liu , Wei Wei , Shi Qihui
Published: March 2017

Cellular heterogeneity has been widely recognized but only recently have single cell tools become available that allow characterizing heterogeneity at the genomic and proteomic levels.
Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors
Authors: Sayeed Ibrahim Bin , Lakshma Nayak V. , Shareef Mohd Adil , Chouhan Neeraj Kumar , Kamal Ahmed
Published: March 2017

A library of imidazopyridine–propenone conjugates (8a–8u) were synthesized and evaluated for their antitumor activity against four human cancer cell lines.
An environmentally friendly route to prepare graphene oxide using concentrated ozone with improved catalytic performance
Authors: Zhang Jin , Zhang Ye , Zhou Ligong , Yang Ying , Li Xuekuan
Published: March 2017

An environmentally friendly route from graphite to graphene oxide (GO) through oxidation using concentrated ozone and with oxygen as the by-product.
Novel fluorescent anthracene–bodipy dyads displaying sensitivity to pH and turn-on behaviour towards Cu(ii) ions
Authors: Vanessa Saura A. , Isabel Burguete M. , Galindo Francisco , Luis Santiago V.
Published: March 2017

The effect of the nature of the spacer in three new bichromophoric compounds showing intramolecular PET and EET processes has been studied.
CO2-Triggered UCST transition of amphiphilic triblock copolymers and their self-assemblies
Authors: Lin Shaojian , Shang Jiaojiao , Theato Patrick
Published: March 2017

Self-assembled vesicles presenting morphological transformations (vesicles–micelles–unimers) upon external stimuli due to their CO2 adjustable UCST behavior in aqueous solution.
Highly cost-effective and high-strength hydrogels as dye adsorbents from natural polymers: chitosan and cellulose
Authors: Tu Hu , Yu Yi , Chen Jiajia , Shi Xiaowen , Zhou Jialin , Deng Hongbing , Du Yumin
Published: March 2017

Cost-effective chitosan/REC/cellulose hydrogels with high-strength are used for highly efficient dye adsorption.
Carbon intercalated porous NaTi2(PO4)3spheres as high-rate and ultralong-life anodes for rechargeable sodium-ion batteries
Authors: Geng Hongbo , Yang Jun , Yu Hong , Li Chengchao , Dong Xiaochen
Published: March 2017

Carbon intercalated porous NaTi2(PO4)3spheres have been synthesized by a facile route. When evaluated as anodes for SIBs, these spheres delivered superior sodium storage performance in terms of high reversible capacity, stable cycling and good rate performances.
Fabrication of core–shell, yolk–shell and hollow Fe3O4@carbon microboxes for high-performance lithium-ion batteries
Authors: Tian Hao , Liu Hao , Yang Tianyu , Veder Jean-Pierre , Wang Guoxiu , Hu Ming , Wang Shaobin , Jaroniec Mietek , Liu Jian
Published: March 2017

Fe3O4@C microboxes with core–shell, yolk–shell and hollow structures were synthesized, the core–shell microboxes exhibited high specific capacity, good rate performance, and exceptional cycling stability.
Enantioselective synthesis of naturally occurring isoquinoline alkaloids: (S)-(−)-trolline and (R)-(+)-oleracein E
Authors: Lin Weilong , Ma Shengming
Published: March 2017

The highly efficient asymmetric synthesis of a pair of enantiomers, (S)-(−)-trolline and (R)-(+)-oleracein E, has been achieved in five steps.
Theoretical insights into photo-induced Curtius rearrangement of chlorodifluoroacetyl azide
Authors: Peng Xing-Liang , Ding Wei-Lu , Li Quan-Song , Li Ze-Sheng
Published: March 2017

The mechanism of photo-induced Curtius rearrangement is a two-step reaction with a nitrene intermediate.
A theoretical study on quasi-one-dimensional open-shell singlet ladder oligomers: multi-radical nature, aromaticity and second hyperpolarizability
Authors: Fukuda Kotaro , Fujiyoshi Jun-ya , Matsui Hiroshi , Nagami Takanori , Takamuku Shota , Kitagawa Yasutaka , Champagne Benoît , Nakano Masayoshi
Published: March 2017

Quasi-one-dimensional open-shell singlet ladder oligomers composed of indenofluorene-like units show strong correlation between multiradical nature, aromaticity and second hyperpolarizability.
Oxygen permeation, thermal expansion behavior and electrochemical properties of LaBa0.5Sr0.5Co2O5+δ cathode for SOFCs
Authors: Subardi Adi , Liao Kun-Yu , Fu Yen-Pei
Published: March 2017

In this study, the double perovskite LaBa0.5Sr0.5Co2O5+δ (LBSC55) is investigated as a potential cathode for solid oxide fuel cells (SOFCs).
Endowing a triarylboron compound showing ACQ with AIE characteristics by transforming its emissive TICT state to be dark
Authors: Liu Jun , Zhang Chenghua , Dong Jun , Zhu Jiang , Shen Chengyi , Yang Guoqiang , Zhang Xiaoming
Published: March 2017

A triarylboron-based AIE fluorophore, TAB-AIE-FL, was designed and synthesized by introducing an electron acceptor to boost charge separation, transforming its TICT state from bright emission to dark.
Amino acid-based amphiphilic hydrogels: metal ion induced tuning of mechanical and thermal stability
Authors: Basak Shibaji , Singh Ishwar , Banerjee Arindam , Kraatz Heinz-Bernhard
Published: March 2017

A phenylalanine based gelator was found to form a hydrogel in phosphate buffer solution. Its mechanical properties are influenced by a range of metal ions.
Correction: A mechanistic insight into the organocatalytic properties of imidazolium-based ionic liquids and a positive co-solvent effect on cellulose modification reactions in an ionic liquid
Authors: Kakuchi Ryohei , Ito Ryo , Nomura Shuhei , Abroshan Hadi , Ninomiya Kazuaki , Ikai Tomoyuki , Maeda Katsuhiro , Kim Hyung J. , Takahashi Kenji
Published: March 2017

Correction for ‘A mechanistic insight into the organocatalytic properties of imidazolium-based ionic liquids and a positive co-solvent effect on cellulose modification reactions in an ionic liquid’ by Ryohei Kakuchi et al., RSC Adv., 2017, 7, 9423–9430.
Correction: Efficient and rapid direct transesterification reactions of cellulose with isopropenyl acetate in ionic liquids
Authors: Kakuchi Ryohei , Yamaguchi Makoto , Endo Takatsugu , Shibata Yoshiki , Ninomiya Kazuaki , Ikai Tomoyuki , Maeda Katsuhiro , Takahashi Kenji
Published: March 2017

Correction for ‘Efficient and rapid direct transesterification reactions of cellulose with isopropenyl acetate in ionic liquids’ by Ryohei Kakuchi et al., RSC Adv., 2015, 5, 72071–72074.
Aluminium-ion batteries: developments and challenges
Authors: Das Shyamal K. , Mahapatra Sadhan , Lahan Homen
Published: March 2017

The resurgence of aluminium-ion batteries re-establishes and reinforces the goal of developing affordable electrical energy storage and generation devices.
In situ growth of Pt3Ni nanoparticles on an A-site deficient perovskite with enhanced activity for the oxygen reduction reaction
Authors: Gao Yang , Wang Jian , Lyu Yu-Qi , Lam Kwunyu , Ciucci Francesco
Published: March 2017

A perovskite material with in situ exsolved Pt3Ni nanoparticles is applied for oxygen reduction reaction catalysis with dramatically improved activity.
Synthesis of hierarchical porous TiNb2O7 nanotubes with controllable porosity and their application in high power Li-ion batteries
Authors: Park Hyunjung , Shin Dong Hyeok , Song Taeseup , Park Won Il , Paik Ungyu
Published: March 2017

TiNb2O7 nanotubes with a hierarchical porous structure show ultra-fast rate capability at an extremely high rate of 50C.
Sn nanoparticles@nitrogen-doped carbon nanofiber composites as high-performance anodes for sodium-ion batteries
Authors: Sha Mo , Zhang Hui , Nie Yuting , Nie Kaiqi , Lv Xiaoxin , Sun Na , Xie Xinkai , Ma Yanyun , Sun Xuhui
Published: March 2017

Sn nanoparticles on nitrogen doped carbon nanofibers (Sn@NCNFs) composites have been synthesized by electrostatic spinning technique and used as the anode of sodium-ion batteries (SIBs) with the capacity of 390 mA h g−1 at 1 C for over 1000 cycles.
Inkjet printing wearable electronic devices
Authors: Gao Meng , Li Lihong , Song Yanlin
Published: March 2017

In this review, the recent advances in inks, strategies, and the applications of inkjet-printed wearable electronics have been summarized.
Resistance to antifungal therapies
Authors: Prasad Rajendra , Banerjee Atanu , Shah Abdul Haseeb
Published: March 2017

The evolution of antifungal resistance among fungal pathogens has rendered the limited arsenal of antifungal drugs futile. Considering the recent rise in the number of nosocomial fungal infections in immunocompromised patients, the emerging clinical multidrug resistance (MDR) has become a matter of grave concern for medical professionals. Despite advances in therapeutic interventions, it has not yet been possible to devise convincing strategies to combat antifungal resistance. Comprehensive understanding of the molecular mechanisms of antifungal resistance is essential for identification of novel targets that do not promote or delay emergence of drug resistance. The present study discusses features and limitations of the currently available antifungals, mechanisms of antifungal resistance and highlights the emerging therapeutic strategies that could be deployed to combat MDR.
Multiple channel error‐correction algorithms for LCC decoding of Reed‐Solomon codes and its high‐speed architecture design
Authors: Wang Lingyu , Zhang Wei , Wang Yang , Hu Yan , Liu Yanyan
Published: March 2017

Reed‐Solomon (RS) code is one of the most widely used error control codes. The decoding algorithms of RS code can be briefly divided into hard‐decision decoding (HDD) and algebraic soft‐decision decoding (ASD). However, traditional RS decoding algorithms perform unsatisfactorily over bursty channel. Therefore, many modified RS decoding algorithms utilised in bursty channel decoding were proposed. However all of them are HDD and the computation is costly. In this study, the authors propose an ASD algorithm which can be utilised both in additive white Gaussian noise channel and bursty channel. In order to be utilised in multiple channel, the proposed algorithm combines original HDD‐based low‐complexity chase (HDD‐LCC) and burst‐error correcting (BC) together. What's more, BC is also modified by adding in the mechanism of pre‐judgement to reduce the iterations of BC. The modified algorithm can give a coding gain reaching up to 0.1268 and 1.33 dB compared with BC and HDD‐LCC, respectively when symbol error rate (SER) is in bursty channel. The proposed RS decoder is implemented and synthesised with Semiconductor Manufacturing International Corporation 0.13‐μm CMOS technology library. The results show the proposed decoder can operate at 200 MHz to achieve the throughput of 1.673 Gbps.
Algorithmus zur Aufnahme und Überwachung von Alkoholisierten im Rahmen der Sanitätsstation auf dem Münchner Oktoberfest
Authors: Fischer F. , Wagner F. , Eyer F.
Published: March 2017

Auf der Sanitätsstation des Münchner Oktoberfestes kommt seit 2010 ein Algorithmus zur Überwachung alkoholisierter Patienten zum Einsatz. Orientiert an ABCDE-Schemen und mit stringenter Überwachung wird somit die Betreuung von rund 18% der behandlungsbedürftigen Patienten sichergestellt. Dadurch ist eine effektive und strukturierte Überwachung gewährleistet, die vorgestellt wird.
Die Segregationsanalyse bei erblichen Augenerkrankungen – akademisches Extra oder notwendiger Aufwand?
Authors: Preising M. , Bolz H.
Published: March 2017

Augenerkrankungen werden zunehmend mit einer genetischen Ursache verknüpft und damit als erblich beschrieben. Besonders im Bereich der Netzhauterkrankungen steht die genetische Ursache im Vordergrund. Aber auch Entwicklungsstörungen des Auges, und hier insbesondere Vorabschnittsdysgenesien, Katarakte und gestörte Entwicklungen der Augengrundstruktur, beruhen häufig auf genetischen Ursachen. Darüber hinaus sind Augenerkrankungen Teilmanifestationen vieler genetisch bedingter Syndrome. Der Stellenwert der Genetik in der Ophthalmologie ist mittlerweile unbestritten. Die genetische Beratung ist Fachärzten für Humangenetik oder Ärzten anderer Fachrichtungen, die über die Zusatzbezeichnung „Medizinische Genetik“ verfügen, vorbehalten. Dennoch werden Augenärzte zunehmend gefordert, weil die Zunahme therapeutischer Optionen ein grundlegendes Wissen um die genetischen Ursachen und ihrer Identifikation erfordert. Erste Voraussetzung ist, potenziell erbliche Augenerkrankungen zu erkennen, um dann eine entsprechende genetische Analyse zur Diagnosesicherung zu veranlassen. Dieser Artikel befasst sich mit den notwendigen und möglichen Untersuchungen in der Familie des Patienten, die nach der Feststellung der genetischen Ursache einer Augenerkrankung auf den Ophthalmologen zukommen.
Social Machines: How Recent Technological Advances have Aided Financialisation
Authors: Ma Tiejun , McGroarty Frank
Published: March 2017

In recent years, financial markets have been fundamentally transformed by innovations in information technology, in particular with regard to the web, social networks, high-speed computer networks and mobile technologies. We borrow the concept of Social Machines from Web Science as a single concept that captures the essence of all these recent technological changes to argue that the emergence of these Social Machines has aided the transformation of financial markets and society. This study explores the formation of these Social Machines with three sample disruptive technologies – automated/high-frequency trading, social network analytics and smart mobile technology. Through critical reflective analysis of these three case studies, we assess the impact of information technology innovation on financialisation. We adopt three case studies – automated trading; market information extraction using social media technologies; and information diffusion and trader decision-making with mobile technology on financial and real sector changes – which demonstrate the increasing trend of transaction velocity, speculative trading, increased complex information network, accelerated inequality and leverage. Our findings demonstrate that technologically enabled financial Social Machines harness crowd wisdom, engage disparate individual traders to produce more accurate price estimations, and have enhanced decision-making capability. However, these same changes can also have a simultaneously detrimental effect on financial and real sectors, in some situations exacerbating underlying distortions, such as misinformation due to complex information networks, speculative trading behaviour, and higher volatility with transaction velocity. Overall, we conclude that these innovations have transformed the fundamental nature of key aspects of the finance industry and society as a whole.
Dynamic high pressure generation through plasma implosion driven by an intense laser pulse
Authors: Li M. , Wang J. X. , Yuan T. , Xu Y. X. , Zhu W. J.
Published: March 2017

When an intense laser pulse is loaded upon solids, very high impact pressure can be generated on the surface. In this letter, we simulate this process through one-dimensional particle-in-cell simulation and find that the pressure as high as 0.13 TPa can be generated after the laser pulse with intensity 1015 W/cm2 and 5 picosecond duration is injected upon a nanometer solid-density plasma. The peak pressure is shown to be resulted from an energetic high-density plasma bunch, produced through plasma implosion under extremely high light pressure.
Microscopic observation of the segmental orientation autocorrelation function for entangled and constrained polymer chains
Authors: Mordvinkin Anton , Saalwächter Kay
Published: March 2017

Previous work on probing the dynamics of reptating polymer chains in terms of the segmental orientation autocorrelation function (OACF) by multiple-quantum (MQ) NMR relied on the time-temperature superposition (TTS) principle as applied to normalized double-quantum (DQ) build-up curves. Alternatively, an initial-rise analysis of the latter is also possible. These approaches are subject to uncertainties related to the relevant segmental shift factor or parasitic signals and inhomogeneities distorting the build-up at short times, respectively. Here, we present a simple analytical fitting approach based upon a power-law model of the OACF, by the way of which an effective power-law time scaling exponent and the amplitude of the OACF can be estimated from MQ NMR data at any given temperature. This obviates the use of TTS and provides a robust and independent probe of the shape of the OACF. The approach is validated by application to polymer melts of variable molecular weight as well as elastomers. We anticipate a wide range of applications, including the study of physical networks with labile junctions.
Improvement in charge transfer dynamic of the porphyrin-based solar cells in water: A theoretical study
Authors: Arkan Foroogh , Izadyar Mohammad , Nakhaeipour Ali
Published: March 2017

In this work, we theoretically investigated the electronic properties of some porphyrin derivatives as sensitizers and described the charge transfer dynamics of the dye-sensitized solar cells (DSSCs) in the gas and water environments through the quantum reactivity indices calculated by the density functional theory (DFT) and time-dependent (TD)-DFT methods. Based on the obtained data on the red shift and high intensity of the absorption peaks of sensitizers, higher ability of harvesting light, lower electron affinity (EA), and Gibbs energy of the electron injection of the studied systems in the presence of water showed an improvement in the solar cell performance. The inverse linear correlation between eVOC with the electronic chemical potential (μ) and chemical electrophilicity (ω) values of the dyes showed that the dyes with less resistance to electron escaping improve the electron injection into the DSSCs. Finally, based on different analyses, an important role of the electrostatic interaction between sensitizers and solvent was confirmed.