bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of UV light on food quality and safety
Authors: Csapó J. , Prokisch J. , Albert Cs. , Sipos P.
Published: January 2020

The recent years have seen a great number of instances when ultraviolet (UV) radiation was used in the preservation process of all sorts of foods. Since the purine and pyrimidine bases of DNA and RNA absorb well the 254 nm radiation, its application with the use of a correct dosage can result in disinfections of various orders of magnitude. It can be particularly effective in cases where technology does not allow a more intensive heat treatment. When used properly, UV treatment can be a competitive procedure in the case of foodstuffs where the large surface area allows for UV rays to penetrate the entire volume of the substance. Incorrectly applied UV treatment may change the composition of foods. Free-radical as well as photochemical reactions can digest the proteins, damage the antioxidants, oxidize the lipids, make changes to the colour and substance, and produce undesirable flavourings and odorous substances. Some vitamins are particularly sensitive to UV irradiation in the course of which losses could reach even 50%. Photosensitive water-soluble vitamins are vitamin C, B12, B6, B2 and folic acid, while vitamins A, K and E are the fat soluble sensitive to light, carotene being the only provitamin with such properties. On the other hand, UV treatment can be a useful tool of food safety because of the photosensitivity of fungal toxins.
Kinematic Comparison of a Heald Frame Driven by A Rotary Dobby with A Cam-Slider, A Cam-Link and A Null Modulator
Authors: Yin Honghuan , Yu Hongbin , Wang Lei
Published: January 2020

The kinematics of the heald frame of a rotary dobby with two different modulator types are analyzed and compared. Kinematic mathematical models of the modulator main shaft, cam unit, and heald frame driven by the rotary dobby with a cam-slider modulator and a cam-link modulator were constructed based on two different cam contours derived from measured points on the conjugate cams of the two modulators. The motion characteristics of the two modulators and a null modulator, the cam unit, and the motion transmission unit are analyzed. The purpose of the present study was to establish the kinematic models, investigate the motion characteristics, and analyze their differences. At the same time, a calculation method for each motion transmission process was established and numerical models were developed. The results demonstrated that the two different modulators produce almost the same heald frame motion characteristics. Despite that both modulator types can be adapted to the requirements of a loom, the cam-link modulator can produce a more stable and reliable motion.
Teachers’ Perceptions of Consumer Education in Primary Schools in Finland
Authors: Pajari Kati , Harmoinen Sari
Published: January 2020

Operating in today’s markets is challenging due to information overload and an expanding choice of products. Children also encounter these complex markets at an early age. Providing consumer education in schools is an excellent opportunity to enhance their ability to think critically and increase their awareness. However, it would be a mistake to ignore the interconnections between consumer education and entrepreneurship education, since active and innovative people are also a prerequisite for future development. Taking advantage of the opportunity to provide consumer education in schools requires teachers to be familiar with consumer issues. This article aims to discuss the perceptions and experiences that primary school teachers in Finland have regarding children’s consumer education in schools. This study was conducted using the phenomenographic qualitative method to analyse data from teacher interviews. The analysis revealed a set of categories that describes the various ways the participants perceive and experience children’s consumer education in schools. These categories include themes, actors, teaching methods and the challenges and expectations teachers relate to children’s consumer education. The findings of this study are worth exploring when planning how to support teachers’ consumer educational competences for a sustainable future. The authors consider that this article is especially valuable for curriculum planners, educators, consumer organisations and parents’ associations, because it shed light on teachers’ perspectives about consumer education.
Changes in the Product Costing Process Driven by Implementation of an Integrated Information System in a Production Company
Authors: Fałat Kamila
Published: January 2020

The article deals with product costing in a manufacturing company and change of costing methodology from normal to standard costing caused by a new integrated information system implementation. The aim of the article is to show the impact of a new integrated information system on product costing. In order to show the consequences of changing the methodology of product costing from normal to standard costing variances between standard costing and normal costing in an international production company were analyzed. For this research comparative analysis was used of unit costs before and after the new system implementation for finished goods. Ten percent of the items had a variance of more than 30% which was caused by errors in the new system settings and mistakes in the normal costs in the old system. The impact of the change of the costing methodology was shown by calculation of the difference between normal cost values and standard cost values ten months after the new integrated information system implementation. To verify the accuracy of standard costs settings, standard costs were compared to actual costs for finished goods and semi-finished goods. In the tenth period only 30% of finished goods and 42% of semi-finished goods showed a variance between standard costs and actual costs lower than 20%. It means that for the rest of the items standard cost assumptions should be checked and corrected. The results of the study indicate that a change in product costing methodology driven by new integrated information system implementation has an impact on company revenues. The direction of the change depends on the accuracy of previous system settings. It is impossible to implement a new system without increase or decrease of sales. The most important limitation of the research is that only one manufacturing company was studied. This was connected with data availability. The research methodology can be used by manufacturing companies to assess the impact of new integrated system implementation on their revenues. Literature concerning integrated information system implementation focuses on its advantages and disadvantages therefore the author of the article wants to concentrate on its impact on the profit and loss account, specifically on revenues.
Usefulness of Sectoral Means in Financial Analyses of Enterprises
Authors: Mioduchowska-Jaroszewicz Edyta
Published: January 2020

Aim: The aim of the paper is to assess the usefulness of sectoral means in financial analyses of enterprises.

Research methods: The article uses a deductive approach to assess the suitability of sectoral means used in analyses of t financial standing of enterprises. The method of analysis and logical construction was used for literature review. The methods of descriptive statistics such as arithmetic means, standard deviation and coefficient of variation were used in order to analyze the data and draw conclusions based on the results.

Contribution: The assessment of the usefulness of sectoral means in the context of their variability seems to be a crucial aspect for the analysis of a company’s financial situation. When assessing the financial standing of an enterprise, it is necessary to use a comparative analysis method, based on, inter alia, a comparison in space. This type of comparison requires the use of sectoral means, whose assessment is extremely important to drawing reliable and correct conclusions regarding the financial situation of a company.
Application of the Project Management Methodology Formation’s Method
Authors: Kononenko Igor , Lutsenko Svitlana
Published: January 2020

Background and Purpose: The selection of a “right” project management methodology for a particular project represents a problem of great importance. Its solution affects crucial project parameters like cost, duration, product quality, and the project’s success in general. The purpose of this study is to present a method for the formation of the project management methodology and illustrate its applicability on a software development project’s example.

Design/Methodology/Approach: In this study, we describe the method of project management methodology formation that allows the forming of a specialized methodology for any IT project considering the fuzziness of information about the project, its environment, and existing expert’s recommendations. The method involves 1) collecting baseline information using a questionnaire, 2) calculating weighted Hamming and Euclidean distances, 3) solving a three-criterion optimization problem using a minimax approach with fuzzy input data.

Results: All six stages of the project management methodology formation’s method (project evaluation, basis selection, alternative methodologies formation, methodology selection, methodology application, and methodology tailoring) were applied to form a specialized project management methodology for an IT project to increase the possibility of its success. The most appropriate alternative based on DSDM was selected and applied to manage the project.

Conclusions: The given method allows the forming of a specialized project management methodology based on the components of Generalized Body of Knowledge for any IT project considering specific conditions of the project and its environment.
The separation of microscale HA in aqueous solution by foam separation technique
Authors: Wenyao Shao , Xiao Gong , Shuming Cui , Ying Lin , Yinghua Lu , Yuqing Chen
Published: January 2020

Hyaluronic acid (HA) has important applications in fields of health care products, cosmetics and clinical medical. However, the unique physiological properties of HA make cost of its traditional separation and extraction process relatively high. Foam separation technique has simple, gentle and efficient advantages on the separation of substances with surface activity by using bubbles as the separation medium. In this paper, natural surfactant CocamideBetaine (CAPB) was used as a foaming agent to explore the technology of microscale HA in aqueous solution by foam separation. The optimum process conditions were determined based on the recovery rate and enrichment ratio of HA by single factor and orthogonal experiment: at room temperature, pH = 7, separating air velocity (v) = 350 mL/min, HA concentration (CHA) = 50 mg/L, adding liquid volume (V) = 200 mL, collecting time (tcol) = 10 min, CAPB concentration (CCAPB) = 0.035 g/L. Under these conditions, HA enrichment ratio (E) equals 6.821 and HA recovery rate (R) equals 66.425%.
Application of Bioremediation Techniques as a Potent Input for the Decontamination of Bitumen-Polluted Water
Authors: Atojunere Eganoosi Esme , Ogedengbe Kolawole
Published: January 2020

Large deposits of natural bitumen are found in some areas of Ondo State, Nigeria. Although the mineral is still unexploited, its seepage is enough to negatively influence the environment, especially water resources. This work was designed to determine the potential of four Bitumen Utilizing Microbes (BUM) for the purification of Bitumen-Polluted Water (BPW). BUM were screened differently with a control on the BPW drawn from the affected communities. The bitumen’s degradation was determined using a supplemented enrichment medium with a sample of the BPW, and the growth was monitored by taking temperature readings, pH values, the optical density at 600 nm, and the total viable count (TVC) on days 7, 14, 21 and 28 respectively. The bitumen removal rate varied with the time of the incubation until after the third week, when the lack of nutrients supposedly set in and toxic metabolites started building up, which slowed down the process. The BUMs were identified as Bacillus firmus, Bacillus lentus, Pseudomonas aeruginosa, and Bacillus alvei. The bitumen removal trend showed that Pseudomonas aeruginosa > Bacillus firmus >Bacillus lentus > Bacillus alvei and the control the least amount of removal.
Approaches, Methods and Tools of Rights of Access to Sunlight around the World
Authors: Hraška Jozef
Published: January 2020

Sunlight has always played an important role in the design of human settlements. Well-designed urban structures, especially in moderate or cold climates, should be assured of direct sunlight in indoor living spaces and also in public spaces. Direct sunlight in a built environment is an important factor for health and well-being, the effective functioning of solar systems, and sustainable construction. However, many problems involved in the exercise of rights of access to sunlight can arise when sunlight is obscured by a tall cityscape. Many states, regions, and cities regulate solar access, but solar rights and landowner rights are in a permanent conflict. The high urban density of many cities with tall skyscrapers accentuates the problem of the availability of sunlight. This paper presents a review of existing regulations and metrics for ensuring the availability of direct sunlight in buildings and of assessment methods that have been adopted in multiple countries and cities. Approaches, methods, and tools of rights of access to sunlight are critically analyzed. The paper also details experiences from former socialist countries where strict long-term strict on direct access to sunlight in flats were applied.
A Generalization of Difference Models of the Bittner Operational Calculus
Authors: Wysocki Hubert
Published: January 2020

In the paper, there has been constructed a discrete model of the non-classical Bittner operational calculus with a derivative understood as the operation S

b
{x(k)} := {x(k+n) − b(k)x(k)}, which is a generalization of the n
th-order forward difference. It has also been pointed out that there is a possibility to generalize operational calculus models with backward and central differences of higher orders.
PENGARUH PERSEPSI NILAI, PERSEPSI RISIKO DAN SIKAP TERHADAP NIAT MEMBELI KEMBALI PADA MAKANAN CEPAT SAJI
Authors: Devi Ni Ketut Eugenia Shara , Aksari Ni Made Asti
Published: January 2020

As the activities of modern society increases, fast food is an alternative for consumption in today’s instant era. This study aims to describe the influence of perceived value, perceived risk, and attitude on repurchase intention of fast food in quick service restaurants in Indonesia. The study samples consist of 100 Indonesians who have graduated from senior high school and have purchased and consumed fast food. Data were collected through online questionnaires and analyzed using Partial Least Square). Research result found that perceived value positively affect attitude, while perceived risk was found to negatively affect attitude. It indicates that the more value consumers received after purchasing and consuming fast food, their attitude towards fast food are more positive, on the other hand, the higher the risk consumers received, their attitude towards fast food becomes less positive. Attitude was found to positively affect repurchase intention of fast food.

Keywords: perceived value, perceived risk, attitude, repurchase intention, fast food.
PERAN SIKAP MEMEDIASI PENGARUH BRAND TRUST TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN
Authors: Lantara Anak Agung Made Oka , Pramudana Komang Agus Satria
Published: January 2020

Consumer purchasing decisions are increasingly increasing because Bali is not only attractive in terms of culture, as a tourism area where many businesses in the food sector, such as restaurants, cafés & bars, have their own uniqueness, both main food and snacks. The purpose of this study was to analyze the role of attitudes to mediate the influence of brand trust on consumer purchasing decisions (Study on Nine-Eleven Café & Concept Store Bali). This research was conducted at Nine-Eleven Café & Concept Store Bali with Path Analysis data analysis techniques. The sample size obtained by using purposive sampling method as many as 110 respondents. Based on the results of the analysis it can be stated that brand trust has a positive and significant effect on consumer purchasing decisions at Nine-Eleven Café & Concept Store Bali. brand trust has a positive and significant effect on consumer attitudes at Nine-Eleven Café & Concept Store Bali. The attitude has a positive and significant effect on consumer purchasing decisions at Nine-Eleven Café & Concept Store Bali. The attitude mediating the positive influence of brand trust on consumer purchasing decisions at Nine-Eleven Café & Concept Store Bali.

Keywords: brand trust, attitude, consumer purchasing decisions
Pengaruh SePENGARUH SERVICE QUALITY TERHADAP CUSTOMER LOYALTY DENGAN CUSTOMER DELIGHT SEBAGAI VARIABEL MEDIASIrvice Quality Terhadap Customer Loyalty Dengan Customer Delight Sebagai Variabel Mediasi
Authors: Putra I Gusti Jaya Khrisna , Suparna Gede
Published: January 2020

The purpose of this study was to analyze the effect of service quality on customer loyalty with customer delight as a mediating variable. This research was conducted at Gardin Bistro & Patisserie Seminyak Bali with Path Analysis data analysis techniques. The sample size obtained by using purposive sampling method as many as 130 respondents. Based on the results of the analysis it can be stated that Service quality has a positive and significant effect on customer loyalty, service quality has a positive and significant effect on customer delight, customer delight has a positive and significant effect on customer loyalty. The results of the study also found that customer delight mediated the influence of service quality on customer loyalty positively and significantly. Gardin Bistro & Patisserie Seminyak Bali needs to rejuvenate the facilities provided and improve the appearance of staff by providing work clothes every year so that the employees are clean and tidy. Management must re-educate every staff who works by providing service training so that they can better serve consumers.

Keywords: service quality, customer delight, customer loyalty
IMPLEMENTASI ACCESSIBLE TOURISM DI TMII JAKARTA
Authors: Lestari Nurul Sukma , Wiastuti Rachel Dyah , Triana Ika
Published: January 2020

Indonesia is a big country consisting of various tribes and has different cultures from one to another. From this came the idea to create a tourist site with a cultural background. Taman Mini Indonesia Indah is a tourist attraction established since 1975, an attraction with the theme of Indonesian culture. Taman Mini Indonesia Indah is still a tourist destination that has been chosen by many families. Likewise, schools that still do a lot of tourist visits for study tours Visitors to Taman Mini Indonesia Indah are still the second most in Jakarta. With the development of tourism, the concept of tourism for all it becomes an absolute necessity. Because throughout the world there is also a very significant increase in the number of tourists, and ten percent have special needs including elderly people, tourists with small children, pregnant women, tourists with permanent and temporary disabilities. Therefore, the purpose of this study is to find out to what extent Taman Mini Indonesia Indah has implemented accessibility in tourism in accordance with standards set by the UNWTO. The method used is descriptive qualitative, where data is obtained through field research, documentation, checklists and literature studies. The results of the study are found that vertical movements still need to be improved because visitors using a wheelchair cannot enjoy all the regional platforms. And the suggestion from the research is to continue to improve the facilities so that everyone can access them by adding braille letters to the brochure and adding audio announcements to every tourist attraction.
KARAKTERISTIK DAN MOTIVASI WISATAWAN MANCANEGARA YANG BERKUNJUNG KE PANTAI LAKEY, DOMPU, NUSA TENGGARA BARAT
Authors: Fitrullah Muhammad , Oka Karini Ni Made , Eka Mahadewi Ni Putu
Published: January 2020

Lakey Beach has potential that is not shared by many other tourist attractions such as left-hand wave sweeping. Not only that, the life of the local people around Lakey Beach tourist attraction which is quite unique and still preserves customs is a special attraction for tourists who visit. For this reason, we want to know the Characteristics, Motivation of foreign tourists visiting Lakey Beach.The sampling technique uses the slovin formula and purposive sampling by distributing 100 open questionnaires to foreign tourists visiting Lakey Beach tourist attractions. The data analysis technique used in this research is descriptive qualitative is a technique that describes and interprets the meaning of the data that has been collected. Based on the results of research characteristics of foreign tourists visiting Lakey Beach based on age 15-30 years old 57 people (57%), the area of origin of Australia 41 people (41%), male gender 5 people (56%), the status of recreational trips / holidays 98 people (98%), sources of friends / family information 54 people (54%), frequency of visiting 63 people (63%), home stay accommodations 59 people (59%). While the intrinsic motivation of foreign tourists on the indicator want to have fun score of 4.2 (agree), want to channel the hobby of surfing / surfing the score of 4.09 (agree) has the highest liker score, while the lowest liker score on the indicator wants to visit friends / liker's family score 2.15 (disagree). Whereas the extrinsic motivation of foreign tourists on the highest liker score indicator is the leisure time score of 4.27 liker (strongly agree), while the indicator with the lowest liker score is conducting a comparative study of liker score 2.16 (disagree).
KARAKTERISTIK DAN POLA PERJALANAN WISATAWAN BACKPACKER YANG MENGINAP DI CANGGU, BADUNG
Authors: Suprani Gama Cening , Sudana I Putu , Leli Kusuma Dewi Luh Gede
Published: January 2020

Canggu is one of the the most visited areas by backpacker tourists viewed by the amount of hostel accommodations. This study aims to determine the characteristics and travel patterns of backpacker tourists who stay in Canggu. The sample of this research is backpacker tourists staying at Canggu, determining the sample using purposive and quota sampling on 132 respondents. Data obtained in several ways, such as: observation, questionnaires, literature study, and documentation. Quantitative descriptive and qualitative descriptive were used to analyse the data result. The results showed that backpacker tourists take an intra-destination travel pattern, which is to travel in Bali, the most visited tourist destination in Bali is Ubud with an average stay of 6 days, dominantly making an intra-destination travel pattern; Ubud-Uluwatu- Canggu, and Kuta as the first tourist destination visited in Bali. Inter-destination travel patterns, while travel between destinations in Indonesia, most backpacker tourists visit Gili Island with an average stay of 5 days, dominantly doing inter-destination travel patterns such as Gili Island-Bali, and Bali as a tourist destination first visited. Intra-regional patterns, as trips made in Southeast Asian countries, Thailand was most visited by backpacker tourists other than Indonesia, dominantly carried out intra-regional travel patterns like Thailand-Cambodia-Vietnam-Indonesia, and Indonesia as first destination visited. Inter-regional patterns, backpacker tourists also visit other countries other than Southeast Asia, and predominantly visit Australia with an average stay of 91 days, and do inter-regional travel patterns that is Australia- ASEAN, and the ASEAN region being the first destination visited.
SINERGITAS PENTAHELIX DALAM PEMULIHAN PARIWISATA PASCA BENCANA ERUPSI GUNUNG API SINABUNG DI KABUPATEN KARO, SUMATERA UTARA
Authors: Rizkiyah Putri , Liyushiana Liyushiana , Herman Herman
Published: January 2020

The eruption of Mount Sinabung had a pretty heavy impact on Karo District, in terms of the tourism economy sector, which has been the signature economy motor of this region. For almost 1 (one) decade, the eruption disaster shook, the recovery effort is still stagnant despite various government efforts. Therefore, this study aims to carry out an inventory of economic recovery, particularly in the tourism sector in Karo District by including the pentahelix synergy model as a surefire strategy to encourage community independence and achieve faster and more sustainable recovery goals. This study uses qualitative research methods with the main data collection techniques through a Focus Group Discussion. The results achieved indicate several strategies can be carried out to restore tourism in Karo District, including: rehabilitation of the image of Karo district as a safe tourist destination, strengthening the disaster awareness movement, infrastructure recovery, to the creation of signature tourism products based on disaster tourism, health tourism and agro tourism. This study also illustrates what roles can be taken by the government, academia, industry, society and the media in each strategy and proposed program.
Trace element behaviour in acidic leachates (acetic, nitric and hydrochloric) from siliciclastic-carbonate rocks of the Upper Riphean Uk formation in the Southern Urals
Authors: Dub S. A. , Cherednichenko N. V. , Kiseleva D. V. , Gorbunova N. P. , Gulyaeva T. Ya. , Deryugina L. K.
Published: January 2020

Research subject. 14 samples of limestone and one sample of carbonate-siliciclastic rock from siliciclastic-carbonate deposits of the Upper Riphean Uk Formation (the Southern Urals) were studied.

Methods. Mineral and chemical composition of the samples were determined; the main tool for detecting the concentrations of trace elements was the ICPMS method. X-ray diffraction analysis was carried out using a Shimadzu XRD-7000 diffractometer, the content of major (rock-forming) oxides in bulk samples was established by X-ray fluorescence spectrometry on the SRM-35 and Shimadzu XRF 1800 spectrometers. Microelement composition of bulk samples and acidic leachates obtained with using acetic (10%), nitric (36%) and hydrochloric (17%) acids was determined on a Perkin Elmer ELAN 9000 spectrometer.

Results. The distribution of lithophile, rare-earth and a number of other elements (Sr, Ni, U) both in bulk samples and in acidic leachates was analyzed. The main carrier phases of these elements were revealed.

Conclusions. 1. The use of any listed acids leads to the non-carbonate component entering the solution, including contamination of the “carbonate” leachates by lithophile elements. In particular, a transition Rb, Zr, Li, Th, Ti, Sc to leachates was noted. This process is most active in nitric and hydrochloric acids, less intensive in acetic acid. 2. Among the carriers of rare earth elements (REE) in the studied rocks are clays (1), accessory minerals (2), including phosphate-bearing grains, secondary carbonate phases represented by dolomite and, possibly (3), finely disseminated iron and manganese (oxy)hydroxides (4). It is assumed that the REE pattern in limestones is determined by the content of the epigenetic dolomite. The contribution of lanthanides bound in the sedimentary calcite crystal lattice in the total REE pattern is rather large only in relatively “pure” limestones. However, the use of acids with such concentrations did not allow to obtain a leachate, which the REE pattern with high probability corresponds to the distribution of REE in the Uk time seawater. But acetic acid is more effective for achieving this goal than the others. 3. In addition to Sr, sedimentary calcite also contains Ni and U.
Evaluation of Aesthetic, Functional, and Environmental Effects on the Design of Urban Open Spaces: A Case Study of istanbul sishane Park, Turkey
Authors: Caymaz Gökçen Firdevs Yücel , Hamameh Samar
Published: January 2020

Urban spaces reflect the reality of city life, like a mirror. This research aims to examine and analyze the advanced aesthetic, functional, and environmental performance of urban public spaces by assessing the current situation and highlighting the role of creativity in developing these spaces. To clarify the research scope, sishane Park in Istanbul, Turkey was studied to define the requirements of creative standards, evaluate these competencies and choose the appropriate architectural style and urban furniture. In addition, to learn ways of preserving those elements for longer life. The analytical descriptive approach was the research method utilized in order to arrive at a set of results that ascertain the reality of the aesthetic, functional, and environmental performance of urban public spaces, and the reflection of the contemporary role in developing these spaces, which can contribute to addressing weaknesses and bolster the strong points in the formation of public urban spaces around the world.
Ella Grant Campbell, 19th Century Florist, Author and Historian
Authors: DelPrince James
Published: January 2020

Floristry evolved from commercial floriculture production and women played a key role in its 19th century development. Ella Lawton Grant Campbell (Wilson) (1854-1939) was an important figure in 19th century American floriculture. Her publication, Floral Designs Series 1, A hand-book for cut-flower workers and florists (1888) aided florists in both constructing and selling floral designs, serving as consumer selection guide and professional technical manual. Her work provided a glimpse into Victorian-era floristry, a significant era in the history of floral design history.
Improving Indonesian Language Learning Activities Using Audiovisual Media at First Grade Students in SDN 36 Sungai Ambawang
Authors: Dalyunah Dalyunah
Published: January 2020

The purpose of this study was to analyze the ability of teachers to carry out Indonesian language learning using audiovisual media in first-grade students of SDN 36 Sungai Ambawang and describe learning activities in learning Indonesian by using audiovisual media on grade I students at SDN (State Elementary School) 36 Sungai Ambawang. The research method used in this study is discrete. The subjects of this study were teachers as researchers in class I, and first-grade students at SDN 36 Sungai Ambaang, totaling 19 students, eight women, and 11 men. The procedure of conducting Indonesian language learning research uses audiovisual media through four stages, namely: a) planning, b) implementation, c) reflection, and d) evaluation. Data collection techniques used are direct observation techniques, with data collection tools in the form of observation sheets. The results showed an increase in the ability of teachers to prepare plans for implementing learning and carrying out learning in Indonesian language lessons using audiovisual media in first-grade students of SDN 36 Sungai Ambawang, and increased activity in learning Indonesian by using audiovisual media in first-grade students of SDN 36 Ambawang River physical activity in cycle I 70% increased in value in cycle II 94%, mental activity increased, cycle I 54.54% and cycle II, emotional activity in from 75% in cycle I to 95.45% in cycle II.
Uniform and Simultaneous Orthogonal Functionalization of a Metal-Organic Framework Material
Authors: Samarakoon Kanchana , Yazdanparast Mohammad , Day Victor W. , Gadzikwa Tendai
Published: January 2020

We report the construction of a large-channel MOF material composed of two linkers that bear orthogonally reactive groups, azides and hydroxyls, that can be addressed independently. The two linkers also have distinct coordination chemistry and assemble in well-defined positions relative to each other throughout the MOF crystals. The subsequent covalent grafting of two different chemical functionalities onto these reactive linkers is both independent and quantitative, yielding uniformly multifunctional confined spaces. To further demonstrate the advantage of orthogonal reactivity, we performed the uniform and quantitative binary MOF functionalization in a simultaneous, one-pot reaction.
Efficient targeted degradation via reversible and irreversible covalent PROTACs
Authors: Gabizon Ronen , Shraga Amit , Gehrtz Paul , Livnah Ella , Gurwicz Neta , Avram Liat , Unger Tamar , Albeck Shira , Shulman Ziv , London Nir
Published: January 2020

PROteolysis Targeting Chimeras (PROTACs) represent an exciting inhibitory modality with many advantages, including sub-stoichiometric degradation of targets. Their scope, though, is still limited to-date by the requirement for a sufficiently potent target binder. A solution that proved useful in tackling challenging targets is the use of electrophiles to allow irreversible binding to the target. However, such binding will negate the catalytic nature of PROTACs. Reversible covalent PROTACs offer the best of both worlds. They possess the potency and selectivity associated with the formation of the covalent bond, while being able to dissociate and regenerate once the protein target is degraded. Using Bruton’s tyrosine kinase (BTK) as a clinically relevant model system, we present a proof-of concept for the first in class cyanoacrylamide reversible covalent PROTACs. We show efficient degradation with reversible covalent PROTACs, as well as their non-covalent and irreversible counterparts. The latter are amongst the most efficient PROTACs reported for BTK. They display single digit nM DC50, full degradation within 2-4 hours, proteome wide selectivity and show ~10-fold better inhibition of B cell activation than Ibrutinib. These examples refute the notion that covalent binders are not suitable as the basis for PROTACs, and may pave the way for the design of covalent PROTACs for a wide variety of challenging targets.
Combining Automated Microfluidic Experimentation with Machine Learning for Efficient Polymerization Design
Authors: Rizkin Benjamin , Shkolnik Albert , Ferraro Neil , Hartman Ryan L.
Published: January 2020

Understanding polymerization reactions has challenges relating to the complexity of the systems, hazards associated with the reagents, environmental footprint of the operations, and the highly non-linear topologies of reaction spaces. In this work, we aim to present a new methodology for studying such complex reactions using machine-learning-assisted automated microchemical reactors. A custom-designed rapidly prototyped microreactor is used in conjunction with in situ infrared thermography and efficient, high-speed experimentation to map the reaction space for a zirconocene polymerization catalyst. Chemical waste was decreased by two orders of magnitude and catalytic discovery was performed in one hour. Here we show that efficient microfluidic technology can be coupled with machine learning algorithms to obtain high-fidelity datasets on a complex chemical reaction.
Total Synthesis of Putative Xestocyclamine A
Authors: Meng Zhanchao , Fürstner Alois
Published: January 2020

The first total synthesis of putative xestocyclamine A (-)-1 is reported, a compound taking center stage on the the pathway explaining the biosynthesis of a prominent family of polycyclic alkaloids (Baldwin-Whitehead pathway). The identity of the synthetic sample is unambiguous but the recorded spectral data deviate from those of xestocyclamine A reported in the literature.
Features of humoral immunity in cows infected with the leukaemia virus
Authors: Talgat R. Yakupov  , Mars M. Valiev  , Farit F. Zinnatov  , Azat M. Alimov  , Albert K. Galiullin  , Damir D. Hairullin  , Radiy M. Papaev  , Sergey Yu. Smolentsev
Published: January 2020

The article presents the results of studying the dynamics of the formation of antibodies and immune complexes, reveals the prospects for improving the early diagnosis of cattle leukaemia. Studies were conducted for 6 months on an experimental group of animals consisting of 12 cows. The titers of free and bound antibodies in blood serum and milk were determined by enzyme-linked immunosorbent assay. The results of studies showing that changes in titers of anti-leukaemia antibodies in the blood serum of cows naturally infected with BLV (bovine leukaemia virus) are significantly different from experimental infection data are adduced. In cows infected with BLV, there is no definite relationship between antibody titers in milk and in blood serum.  With sufficiently high titers of serum antibodies, antibody titers in milk can be minimal for the same cows; conversely, with low titers of serum antibodies, there can be high antibody titers in milk.  In the titers of antibodies free and bound in the immune complexes in blood serum with the development of the disease, a certain dependence is traced. With a decrease in titers of free antibodies, in most cases, an increase in titers of “bound” antibodies is observed, i.e., the degree of formation of circulating immune complexes (CECs) increases. There is no clearly defined dependence in the dynamics of changes in titers free and bound in immune complexes of antibodies in milk samples. They can remain at the same level for a long time, both at low and rather high levels.
SABERES CIENTÍFICOS E PEDAGÓGICOS DE CONTEÚDOS DE CIÊNCIAS NATURAIS EXPRESSOS POR PEDAGOGOS DO ENSINO FUNDAMENTAL
Authors: Santos Zelia Alves dos , Ribeiro Marcel Thiago Damasceno
Published: January 2020

Este artigo é um recorte de uma pesquisa de mestrado e busca compreender a experiência de pedagogos ao trabalharem com a disciplina de Ciências Naturais nos anos iniciais do Ensino Fundamental. Para tanto, apresenta-se a seguinte questão: Como se configuram e se expressam saberes científicos e pedagógicos de conteúdos de Ciências Naturais subjacentes à professores dos anos iniciais, ao relatarem o ensino que realizam no Ensino Fundamental? Assim, assumiu-se como método de pesquisa a abordagem qualitativa partindo dos pressupostos da Pesquisa Narrativa. Como registros de textos de campo, optou-se por questionário e entrevista semiestruturada. Para analisar e produzir os textos de campo, adotou-se a Análise Textual Discursiva. Os resultados legitimaram contradições nos relatos dos pedagogos que ensinam Ciências Naturais pois apontam saberes incompletos que podem estar em constituição segundo o desenvolvimento profissional docente. Diante disso, destaca-se a necessidade de cursos de formação inicial em Pedagogia que considerem nas suas propostas curriculares as particularidades de um ensino interdisciplinar, de maneira que proporcionem possibilidades de formação de profissionais reflexivos, que favoreça a prática coletiva, o diálogo, a reflexão entre as diversas disciplinas, vislumbrando a construção de um aprendizado significativo e contextualizado para os estudantes.
A OLIMPÍADA BRASILEIRA DE FÍSICA DAS ESCOLAS PÚBLICAS NO ACRE: RESULTADOS E INFLUÊNCIA DA VULNERABILIDADE SOCIOECONÔMICA
Authors: Junior Eloi Benicio de Melo , Souza Cleyton Assis Loureiro de , Silva Marcelo Castanheira da
Published: January 2020

A presente pesquisa tem o objetivo de estudar a participação e o rendimento estadual dos participantes sujeitos à vulnerabilidade social e econômica na Olimpíada Brasileira de Física das Escolas Públicas (OBFEP) do estado do Acre, durante as edições de 2015 a 2018. A pesquisa, de caráter descritivo, utilizou uma abordagem qualitativa, pela qual foram comparados os resultados da primeira e segunda fases, analisando se as condições locais (sociais e econômicas) tiveram influência nos resultados obtidos pelos participantes. Também teve uma abordagem quantitativa, uma vez que os dados referentes à participação nas edições em questão foram analisados. Participaram dessas edições um total de 1.602 alunos, dos quais três foram medalhistas. Concluiu-se que os resultados abaixo da média estão ligados a essas condições. Sugerem-se alternativas para difundir a OBFEP no estado, assim como propostas para atenuar as desigualdades escolares, de modo que os resultados positivos na OBFEP sejam consequência de práticas inclusivas e inovadoras.
A ALDEIA E O URBANO NO CONTEXTO DA GLOBALIZAÇÃO: QUESTIONAMENTOS E REFLEXÕES
Authors: Netto Evaristo Giovannetti , Gaspar Waldir José , Oliveira Morane Almeida de
Published: January 2020

Este artigo pretende discutir as mazelas causadas pela pós-modernidade alimentadas pela globalização e a dominação do sistema capitalista dentro do contexto das minorias inseridas nas cidades, em especial aos indígenas. O foco da pesquisa priorizou contextualizar a identidade e liberdade dos indígenas e compreender a intensidade das interações humanas na realidade das esferas sociais, econômicas e políticas. Dentre outros autores, como linha mestra para o embasamento teórico, foram analisadas as premissas sobre o liberalismo e liberdade humana contidos nos estudos de Weber (1974), a identidade coletiva comentada em Sennett (1988), a vulnerabilidade da população em Safatle (2015), a desigualdade social de Piketty (2015) e os aspectos da diferença cultural nos estudos de Bauman (1998 e 2013). Conclui-se, nesta investigação que o momento histórico do qual pertencemos, configura-se fluido e tenso, que tendências opostas à individualidade e à globalidade se manifestam na dimensão local, e os atores engajados a estas novas interpretações, anseiam por estabelecer um novo corpus teórico capaz de instrumentalizar novas pesquisas e análises.
O MULTICULTURALISMO E A FORMAÇÃO DE PROFESSORES DE CIÊNCIAS BIOLÓGICAS
Authors: Sousa Aparecida Gasquez de , Penha Maranei Rohers , Teixeira Érica Jaqueline Pizapio
Published: January 2020

O debate acerca do multiculturalismo e da diversidade cultural vem se intensificando nas últimas décadas. Tal debate não pode ficar à margem das discussões acerca das necessidades formativas dos professores, pois as escolas compõem a sociedade, e os professores irão se deparar com questões relativas à diversidade cultural nos espaços educacionais, principalmente nas salas de aula. Documentos recentes que norteiam a formação de professores, como as Diretrizes Curriculares Nacionais para a formação de professores para a Educação Básica, trazem orientações para que essa temática seja contemplada nos cursos de licenciatura de todas as áreas. Este artigo, de natureza bibliográfica, tem como objetivo discutir a inserção do multiculturalismo em currículos de cursos de licenciatura de Ciências Biológicas. A partir do referencial teórico de Moreira (2002), Canen (2010), Silva (2000) e Hypólito e Moreira (2003), são vislumbrados alguns caminhos para a inserção dessa temática nos currículos de formação de professores da referida disciplina, tais como dinâmicas de sensibilização de identidades; ancoragem social de conteúdos; necessidade de reescrever o conhecimento a partir da visão dos diferentes grupos, de forma a desafiar a lógica de construção dos conhecimentos que privilegiou o eurocentrismo, o masculino e o branco; e discussões sobre a pseudoneutralidade da Ciência.
PRÁTICAS EDUCATIVAS INTERDISCIPLINARES NO ENSINO MÉDIO USANDO ELEMENTOS DA NATUREZA
Authors: Oliveira Ercilene do Nascimento Silva de , Terán Augusto Fachín
Published: January 2020

Este estudo apresenta um levantamento sobre o tema da interdisciplinaridade no ensino médio brasileiro. O objetivo foi identificar se na produção científica há pesquisas que evidenciem a temática da interdisciplinaridade com o uso de elementos da natureza como meio facilitador para o ensino. A pesquisa é do tipo bibliográfica, com a busca de artigos na base de dados do Portal de Periódicos da Capes, no período de 2010 a 2019. Foram identificados 442 trabalhos, dos quais 414 foram artigos, 23 livros e 5 recursos textuais. Do total de artigos identificados, 53 tinham relação direta com o termo interdisciplinaridade e ensino médio. Evidenciamos diversas situações de estudo com práticas interdisciplinares, contudo há uma lacuna em pesquisas sobre o uso dos elementos da natureza numa abordagem interdisciplinar no ensino médio e, portanto, é visível o emergente aprofundamento das discussões sobre o tema.
Principals’ Decision-Making Practices at Public Degree Colleges Sindh: Teachers’ Perceptions
Authors: Hussain Riaz , Hamid Shams , Arif Imtiaz
Published: January 2020

This study investigates the impact of principal’s commitment on the power, college culture, and college effectiveness in decision-making practices at public degree colleges of Sindh and to determine the effect of participative decision-making to improve the overall performance of teachers and students. The sample comprising n=646 (n=426 (66%) male and n=220 (34%) female) teachers was randomly selected from amongst 122 colleges out of 244 public degree colleges of Sindh. The principal’s decision-making practices were measured through four latent well-established constructs, which include principal’s commitment, principal’s power, college culture, and college effectiveness. This study is quantitative in nature wherein the researcher used exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to estimate the validity and reliability of the measurement or outer model through SPSS version 19 and AMOS statistical software. However, the model fitness was ensured with the help of seven frequently reported goodness of fit indices. Results revealed that there is a statistically significant impact of principals’ commitment on power as sig. value is .000, there is a statistically significant impact of principals’ power on college culture as sig. value is .035 and there is a statistically significant impact of college culture on college effectiveness as sig. value is .007 in decision-making practices at public degree colleges of Sindh. Future studies may ascertain the impact of principal’s power and commitment on the college effectiveness using college culture as mediator in participatory decision-making practices in the context of Pakistan.
José Antonio Corrales. Cartas de América
Authors: Martín Domínguez Nicolás
Published: January 2020

Para el concurso del Pabellón Español en la Feria Mundial de Nueva York de 1965, Corrales y Molezún, de manera sorprendente se presentaron en solitario. Darían muestra así, de la confianza individual en sus arquitecturas, junto a su valentía personal que, tras el éxito compartido de Bruselas, podría volver aquí a repetirse. Ir en solitario, entrañaba quizá mayor riesgo. Entre 1962 y 1968, Corrales se presentaba en solitario a tres concursos más como anticipo o corolario de la sección del proyecto americano. También construiría una casa hoy desaparecida. De programas, superficies y emplazamientos diversos, el trasvase de ideas entre todos ellos se hace evidente. Las operaciones se repiten: sobre lugares en apariencia anodinos o complicados, Corrales inventará nuevos Lugares. La sección oblicua depositada en el lugar es la herramienta por él elegida. Su perfeccionamiento paulatino se desvela en su búsqueda para alcanzar sus objetivos. La sección del Pabellón de Nueva York ya se muestra nítida, como punto de inflexión. Fugaz como la propia Exposición nos invita a observarla con atención. Referencia clara que nos permite apreciar lo ocurrido en su obra en solitario en los años anteriores y posteriores.Mis visitas semanales a su estudio durante 2010, me permitieron descubrir multitud de proyectos, dibujos y poemas. Algunos de ellos inéditos ven aquí la luz por vez primera. No son otra cosa que la esencia manifiesta del propio José Antonio Corrales.