bluuebunny/crossref_metadata_2025 huggingface dataset:
Seed biology of alkali barnyardgrass (Echinochloa crus-galli var. zelayensis) and junglerice (Echinochloa colona) for improved management in direct-seeded rice
Authors: Zhang Zichang , Wang Hongchun , Cao Jingjing , Li Gui , Chauhan Bhagirath Singh
Published: February 2023

Alkali barnyardgrass [Echinochloa crus-galli var. zelayensis (Kunth) Hitchc] and junglerice [Echinochloa colona (L.) Link] are problematic annual weeds in direct-seeded rice (Oryza sativa L.) fields in China. The emergence ecology of the two weed species may differ in response to environmental factors. Laboratory and screenhouse experiments were conducted to evaluate the effects of light, burial depth, mulching with wheat (Triticum aestivum L.) residue, and time and depth of flooding on the emergence of the two weed species collected from Nanjing, China. Light strongly increased seed germination. Under dark conditions, E. crus-galli seed germination (85%) was higher than that of E. colona (70%). The seeds of both species exhibited the greatest germination (90% for E. crus-galli and 80% for E. colona) when sown on the soil surface, and emergence decreased with increasing soil burial depth. Burial depths of 2.2 and 1.4 cm reduced seedling emergence by 50% for E. crus-galli and E. colona, respectively. No emergence was found at a depth of 6 cm. The seedling emergence for E. colona was lower than for E. crus-galli at the same soil burial depth. Mulching with wheat residue considerably reduced the seedling emergence and aboveground biomass of both species. The inhibitory effect of mulching with wheat residue on E. colona was more notable than on E. crus-galli. Early and deep flooding significantly suppressed the emergence, height, and biomass of E. crus-galli and E. colona, especially E. colona. The results gained from this study could provide fundamental ecological knowledge for managing Echinochloa species in direct-seeded rice systems.
First report of a wide distribution of glyphosate-resistant compact brome (Bromus madritensis) in the Iberian Peninsula: confirmation and field management
Authors: Vázquez-García José G. , Castro Patricia , Royo-Esnal Aritz , Palma-Bautista Candelario , Torra Joel , De Prado Rafael
Published: February 2023

Glyphosate resistance is spreading in Spain and Portugal due to excessive herbicide use, in both annual and perennial crops. Compact brome (Bromus madritensisL.) is increasing in frequency in these different cropping systems when under conservation agriculture, particularly when glyphosate fails to control it. Fourteen populations from different areas in the Iberian Peninsula were confirmed as beingB. madritensisusing simple sequence repeat markers and clearly separated from the closely related species red brome (Bromus rubensL.) and ripgut brome (Bromus diandrusRoth). SixB. madritensispopulations were classified as resistant, according to both their shikimic acid accumulation levels and their resistance factors based on LD50or GR50(values between 4 and 8). Populations with higher resistance factors also showed lower shikimic acid concentrations. Moreover, these resistant populations were able to survive the minimum registered dose for glyphosate in Spain in perennial crops (1,080 g ae ha−1, five populations) or in arable crops before seeding for annual weeds (540 g ae ha−1, one population), under both greenhouse and field conditions. The trials carried out in a glyphosate-resistant field during 2 consecutive years showed that acceptable control (≥90%) was only consistently achieved 90 d after application for preemergence treatment with flazasulfuron in a tank mix with glyphosate, while control with postemergence treatments, such as propaquizafop plus glyphosate, was below 80%. This research describes the first herbicide-resistance report for the weed speciesB. madritensis, confirming the presence of glyphosate-resistant populations mainly in perennial cropping systems but also in winter cereals from Spain. Due to the limited chemical tools to manage these populations, there is an urgent need for farmers to implement integrated weed management strategies.
The Effects of Semantic and Syntactic Prediction on Reading Aloud
Authors: Gavard Elisa , Ziegler Johannes C.
Published: February 2023

Abstract. Semantic and syntactic prediction effects were investigated in a word naming task using semantic or syntactic contexts that varied between three and six words. Participants were asked to read the contexts silently and name a target word, which was indicated by a color change. Semantic contexts were composed of lists of semantically associated words without any syntactic information. Syntactic contexts were composed of semantically neutral sentences, in which the grammatical category but not the lexical identity of the final word was highly predictable. When the presentation time of the context words was long (1,200 ms), both semantically and syntactically related contexts facilitated reading aloud latencies of target words and syntactically related contexts produced larger priming effects than semantically related contexts in two out of three analyses. When the presentation time was short (200 ms), however, syntactic context effects disappeared, while semantic context effects remained significant. Across the three experiments, longer contexts produced faster response latencies, but longer contexts did not produce larger priming effects. The results are discussed in the context of the extant literature on semantic and syntactic priming and more recent evidence, suggesting that syntactic information constrains single word recognition.
Protracted Thermal Evolution of a Migmatitic Terrane as Revealed by Multiple Geochronometers From the Retro‐Arc of the Early Paleozoic Famatinian Orogen in NW Argentina
Authors: Farias Pablo , Weinberg Roberto F. , Sola Alfonso , Finch Melanie
Published: February 2023

U‐Pb dates of zircon, monazite, and titanite combined with trace element composition, allows characterization of the thermal evolution of the migmatitic Agua del Sapo complex. This complex comprises Al‐rich and Ca‐rich metasedimentary rocks with a detrital zircon maximum depositional age of 550 Ma. The rocks record two consecutive early Paleozoic orogenies. During subduction associated with the 550–510 Ma Pampean orogeny, the complex was in the fore‐arc region and was intruded by 550–520 Ma granites indicative of anomalous heating possibly related to ridge subduction. During the subsequent 500–440 Ma Famatinian orogeny, the arc migrated trenchwards and the region became part of a retro‐arc that underwent melting at upper‐amphibolite facies. This event was recorded differently by each of the accessory phases. Detrital zircon cores were overgrown by rare Famatinian rims that range from 500 to 420 Ma, while monazite records only Famatinian dates with a growth peak at ∼457 Ma that extends to 410 Ma, possibly due to coupled dissolution‐precipitation. Published titanite dates define a 120 Myr thermal history, starting at ∼500 Ma with temperatures of ∼750°C ± 25°C, ending at 380 Ma and ∼700°C ± 25°C. Cooling was accompanied by a decrease in titanite light rare earth element contents in response to increased abundance of allanite/epidote. Thus, the complementary time‐compositional record of the accessory phases reveals continued high heat flow, associated with deformation, to 380 Ma. This prolonged event blurs the boundary between the Famatinian and the subsequent Achalian/Chanic orogenies and extends the Silurian Rinconada tectonic phase of the Famatinian orogeny to the east into the Eastern Sierras Pampeanas.
Bringing Multisectoral and Multidisciplinary Stakeholders Together to Optimize Environmental Health Research
Authors: Rosofsky A. S. , Vorhees D. J.
Published: February 2023

Incorporating multisectoral and multidisciplinary stakeholder perspectives into environmental health research planning and implementation can help increase the utility of the research. It can also enhance the likelihood of stakeholders using the research to inform decisions. Health Effects Institute (HEI) Energy, a funding and research organization, undertook a multiyear research planning process to build its stakeholder network and integrate their perspectives, knowledge, and priorities into research on potential exposures and health effects associated with unconventional oil and gas development. This commentary describes that process, lessons learned, and how stakeholder involvement shaped HEI Energy's inaugural program of research and associated stakeholder engagement.
Variation of Proportionality Between Stress Drop and Slip, With Implications for Megathrust Earthquakes
Authors: Wu Baoning , Kyriakopoulos Christodoulos , Oglesby David D. , Ryan Kenny J.
Published: February 2023

Earthquake stress drop Δσ is related to fault slip via , where μ, D, and Lc denote shear modulus, average slip, and fault dimension. C is controlled by the system geometry, characterizes the effective stiffness of the system, and is commonly assumed to be a constant near 1. We use 3D elastostatic models to systematically investigate how C is controlled by fault burial depth, dip angle, and slip direction. We find that C decreases with smaller burial depth and dip angle, with a value for a shallow‐dipping surface‐rupturing fault roughly one‐fifth that of the deeply buried case. Our results help explain the apparent magnitude‐dependent stress drops of megathrust earthquakes in Thingbaijam et al. (2017), https://doi.org/10.1785/0120150291. There may also be implications for the apparent depth‐ and magnitude‐dependence in other source parameters, and for reducing uncertainties in the seismic and tsunami hazard assessments of megathrust earthquakes.
A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection
Authors: Preston Simon P. , Allison Cody C. , Schaefer Jan , Clow William , Bader Stefanie M. , Collard Sophie , Forsyth Wasan O. , Clark Michelle P. , Garnham Alexandra L. , Li-Wai-Suen Connie S. N. , Peiris Thanushi , Teale Jack , Mackiewicz Liana , Davidson Sophia , Doerflinger Marcel , Pellegrini Marc
Published: February 2023

Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired immunity. These constraints make it difficult to define the relevance of necroptosis in diseases such as chronic and persistent viral infections and within individual organ systems. The role of necroptotic signalling is further complicated because proteins essential to this pathway, such as receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL), have been implicated in roles outside of necroptotic signalling. We sought to address this issue by individually defining the role of RIPK3 and MLKL in chronic lymphocytic choriomeningitis virus (LCMV) infection. We investigated if necroptosis contributes to the death of LCMV-specific CD8+ T cells or virally infected target cells during infection. We provide evidence showing that necroptosis was redundant in the pathogenesis of acute forms of LCMV (Armstrong strain) and the early stages of chronic (Docile strain) LCMV infection in vivo. The number of immune cells, their specificity and reactivity towards viral antigens and viral loads are not altered in the absence of either MLKL or RIPK3 during acute and during the early stages of chronic LCMV infection. However, we identified that RIPK3 promotes immune dysfunction and prevents control of infection at later stages of chronic LCMV disease. This was not phenocopied by the loss of MLKL indicating that the phenotype was driven by a necroptosis-independent function of RIPK3. We provide evidence that RIPK3 signaling evoked a dysregulated type 1 interferone response which we linked to an impaired antiviral immune response and abrogated clearance of chronic LCMV infection.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
Authors: Sun Kangyue , Chen Lu , Li Yiwen , Huang Bing , Yan Qun , Wu Changjie , Lai Qiuhua , Fang Yuxin , Cai Jianqun , Liu Yongfeng , Chen Junsheng , Wang Xinke , Zhu Yuxuan , Dong Shuyu , Tan Jieyu , Li Aimin , Liu Side , Zhang Yue
Published: February 2023

miR-17-5p has been found to be involved in the proliferation and metastasis of colorectal cancer (CRC), and N6-methyladenosine (m6A) modification is the most common RNA modification in eukaryotes. However, whether miR-17-5p contributes to chemotherapy sensitivity in CRC via m6A modification is unclear. In this study, we found that overexpression of miR-17-5p led to less apoptosis and lower drug sensitivity in vitro and in vivo under the 5-fluorouracil (5-FU) treatment, which indicated miR-17-5p led to 5-FU chemotherapy resistance. Bioinformatic analysis suggested that miR-17-5p-mediated chemoresistance was associated with mitochondrial homeostasis. miR-17-5p directly bound to the 3’ untranslated region of Mitofusin 2 (MFN2), leading to decreased mitochondrial fusion and enhanced mitochondrial fission and mitophagy. Meanwhile, methyltransferase-like protein 14 (METTL14) was downregulated in CRC, resulting in lower m6A level. Moreover, the low level of METTL14 promoted the expression of pri-miR-17 and miR-17-5p. Further experiments suggested that m6A mRNA methylation initiated by METTL14 inhibits pri-miR-17 mRNA decay via reducing the recognition of YTHDC2 to the “GGACC” binding site. The METTL14/miR-17-5p/MFN2 signaling axis may play a critical role in 5-FU chemoresistance in CRC.
Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats
Authors: Brieño-Enríquez Miguel Angel , Faykoo-Martinez Mariela , Goben Meagan , Grenier Jennifer K. , McGrath Ashley , Prado Alexandra M. , Sinopoli Jacob , Wagner Kate , Walsh Patrick T. , Lopa Samia H. , Laird Diana J. , Cohen Paula E. , Wilson Michael D. , Holmes Melissa M. , Place Ned J.
Published: February 2023

In the long-lived naked mole-rat (NMR), the entire process of oogenesis occurs postnatally. Germ cell numbers increase significantly in NMRs between postnatal days 5 (P5) and P8, and germs cells positive for proliferation markers (Ki-67, pHH3) are present at least until P90. Using pluripotency markers (SOX2 and OCT4) and the primordial germ cell (PGC) marker BLIMP1, we show that PGCs persist up to P90 alongside germ cells in all stages of female differentiation and undergo mitosis both in vivo and in vitro. We identified VASA+ SOX2+ cells at 6 months and at 3-years in subordinate and reproductively activated females. Reproductive activation was associated with proliferation of VASA+ SOX2+ cells. Collectively, our results suggest that highly desynchronized germ cell development and the maintenance of a small population of PGCs that can expand upon reproductive activation are unique strategies that could help to maintain the NMR’s ovarian reserve for its 30-year reproductive lifespan.
Electrical and magnetic anisotropies in van der Waals multiferroic CuCrP2S6
Authors: Wang Xiaolei , Shang Zixuan , Zhang Chen , Kang Jiaqian , Liu Tao , Wang Xueyun , Chen Siliang , Liu Haoliang , Tang Wei , Zeng Yu-Jia , Guo Jianfeng , Cheng Zhihai , Liu Lei , Pan Dong , Tong Shucheng , Wu Bo , Xie Yiyang , Wang Guangcheng , Deng Jinxiang , Zhai Tianrui , Deng Hui-Xiong , Hong Jiawang , Zhao Jianhua
Published: February 2023

Multiferroic materials have great potential in non-volatile devices for low-power and ultra-high density information storage, owing to their unique characteristic of coexisting ferroelectric and ferromagnetic orders. The effective manipulation of their intrinsic anisotropy makes it promising to control multiple degrees of the storage “medium”. Here, we have discovered intriguing in-plane electrical and magnetic anisotropies in van der Waals (vdW) multiferroic CuCrP2S6. The uniaxial anisotropies of current rectifications, magnetic properties and magnon modes are demonstrated and manipulated by electric direction/polarity, temperature variation and magnetic field. More important, we have discovered the spin-flop transition corresponding to specific resonance modes, and determined the anisotropy parameters by consistent model fittings and theoretical calculations. Our work provides in-depth investigation and quantitative analysis of electrical and magnetic anisotropies with the same easy axis in vdW multiferroics, which will stimulate potential device applications of artificial bionic synapses, multi-terminal spintronic chips and magnetoelectric devices.
First measurements of p11B fusion in a magnetically confined plasma
Authors: Magee R. M. , Ogawa K. , Tajima T. , Allfrey I. , Gota H. , McCarroll P. , Ohdachi S. , Isobe M. , Kamio S. , Klumper V. , Nuga H. , Shoji M. , Ziaei S. , Binderbauer M. W. , Osakabe M.
Published: February 2023

Proton-boron (p11B) fusion is an attractive potential energy source but technically challenging to implement. Developing techniques to realize its potential requires first developing the experimental capability to produce p11B fusion in the magnetically-confined, thermonuclear plasma environment. Here we report clear experimental measurements supported by simulation of p11B fusion with high-energy neutral beams and boron powder injection in a high-temperature fusion plasma (the Large Helical Device) that have resulted in diagnostically significant levels of alpha particle emission. The injection of boron powder into the plasma edge results in boron accumulation in the core. Three 2 MW, 160 kV hydrogen neutral beam injectors create a large population of well-confined, high -energy protons to react with the boron plasma. The fusion products, MeV alpha particles, are measured with a custom designed particle detector which gives a fusion rate in very good relative agreement with calculations of the global rate. This is the first such realization of p11B fusion in a magnetically confined plasma.
Modified unified critical state model for soils considering over-consolidation and cyclic loading behaviours
Authors: Wang Xiaowen , Yuan Ran , Cui Kai
Published: February 2023

This paper presents a modified unified critical state model to predict the mechanical responses of both clays and sands under over-consolidation and cyclic loading conditions on the basis of clay and sand model (CASM), which is named as CASM-kII. Through the application of subloading surface concept, CASM-kII is able to describe the plastic deformation inside the yield surface and the reverse plastic flow, and is thus expected to capture the over-consolidation and cyclic loading behaviours of soils. CASM-kII is numerical implemented by the using of the forward Euler scheme with automatic substepping and error control. Then, a sensitivity study is carried out to check the influences of the three new parameters of CASM-kII on the mechanical response of soils in over-consolidation and cyclic loading conditions. Through the comparisons of experimental data and simulated results, it is found that CASM-kII is able to satisfactorily describe the mechanical responses of both clays and sands in over-consolidation and cyclic loading conditions.
Decadal cyclical geological atmospheric emissions for a major marine seep field, offshore Coal Oil Point, Southern California
Authors: Leifer Ira
Published: February 2023

The greenhouse gas, methane, budget has significant uncertainty for many sources, including natural geological emissions. A major uncertainty of geological methane emissions, including onshore and offshore hydrocarbon seepage from subsurface hydrocarbon reservoirs is the gas emissions’ temporal variability. Current atmospheric methane budget models assume seepage is constant; nevertheless, available data and seepage conceptual models suggest gas seepage can vary considerably on timescales from second to century. The assumption of steady-seepage is used because long-term datasets to characterize these variabilities are lacking. A 30-year air quality dataset downwind of the Coal Oil Point seep field, offshore California found methane, CH4, concentrations downwind of the seep field increased from a 1995 minimum to a 2008 peak, decreasing exponentially afterward with a 10.2-year timescale (R2 = 0.91). Atmospheric emissions, EA, were derived by a time-resolved Gaussian plume inversion model of the concentration anomaly using observed winds and gridded sonar source location maps. EA increased from 27,200 to 161,000 m3 day−1 (corresponding to 6.5–38 Gg CH4 year−1 for 91% CH4 content) for 1995–2009, respectively, with 15% uncertainty, then decreased exponentially from 2009 to 2015 before rising above the trend. 2015 corresponded to the cessation of oil and gas production, which affects the western seep field. EA varied sinusoidally with a 26.3-year period (R2 = 0.89) that largely tracked the Pacific Decadal Oscillation (PDO), which is driven on these timescales by an 18.6-year earth-tidal cycle (27.9-year beat). A similar controlling factor may underlie both, specifically varying compressional stresses on migration pathways. This also suggests the seep atmospheric budget may exhibit multi-decadal trends.
Anti-DEspR antibody treatment improves survival and reduces neurologic deficits in a hypertensive, spontaneous intracerebral hemorrhage (hsICH) rat model
Authors: Herrera Victoria L. M. , Gromisch Christopher M. , Decano Julius L. , Pasion Khristine Amber , Tan Glaiza L. A. , Hua Ning , Takahashi Courtney E. , Greer David M. , Ruiz-Opazo Nelson
Published: February 2023

Progressive secondary brain injury—induced by dysregulated neuroinflammation in spontaneous intracerebral hemorrhage (sICH)—underlies high sICH-mortality and remains without FDA-approved pharmacotherapy. Clinical insight that hematoma-directed interventions do not improve mortality prioritizes resolving acute secondary brain injury in sICH. As neutrophils are implicated in sICH secondary brain injury, we tested whether inhibition of a rogue neutrophil-subset expressing the dual endothelin-1/signal peptide receptor (DEspR) and associated with secondary tissue injury, DEspR+ CD11b+ immunotype, will attenuate mortality in a hypertensive-sICH (hsICH) rat model. We confirmed sICH-related deaths in hsICH-rats by T2*-weighted 9.4 T MRI and DEspR+ neutrophils in hsICH-rat brain perihematomal areas by immunostaining. At acute sICH, anti-DEspR muIgG1-antibody, mu10a3, treatment increased median survival in hsICH rats vs controls (p < 0.0001). In pre-stroke sICH, weekly 10a3-treatment did not predispose to infection and delayed sICH-onset vs controls (p < 0.0001). As potential sICH-therapeutic, we tested humanized anti-DEspR IgG4S228P-mAb, hu6g8. In vitro, hu6g8 reversed delayed-apoptosis in DEspR+ CD11b+ neutrophils. In vivo, hu6g8 increased median survival and reduced neurologic symptoms in male/female hsICH-rats vs controls (p < 0.0001). Altogether, preclinical efficacy of inhibition of DEspR+ CD11b+ neutrophils in acute sICH—without infection complications, supports the potential of anti-DEspR therapy in sICH. Data provide basis for clinical study of DEspR+ CD11b+ neutrophil-subset in sICH patients.
Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment
Authors: Szabo Peter M. , Vajdi Amir , Kumar Namit , Tolstorukov Michael Y. , Chen Benjamin J. , Edwards Robin , Ligon Keith L. , Chasalow Scott D. , Chow Kin-Hoe , Shetty Aniket , Bolisetty Mohan , Holloway James L. , Golhar Ryan , Kidd Brian A. , Hull Philip Ansumana , Houser Jeff , Vlach Logan , Siemers Nathan O. , Saha Saurabh
Published: February 2023

Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these associations are largely unknown. We studied several tumor types to identify the source of EMT gene expression signals and a potential mechanism of resistance to immuno-oncology treatment. Across tumor types, EMT-related gene expression was strongly associated with expression of stroma-related genes. Based on RNA sequencing of multiple patient-derived xenograft models, EMT-related gene expression was enriched in the stroma versus parenchyma. EMT-related markers were predominantly expressed by cancer-associated fibroblasts (CAFs), cells of mesenchymal origin which produce a variety of matrix proteins and growth factors. Scores derived from a 3-gene CAF transcriptional signature (COL1A1, COL1A2, COL3A1) were sufficient to reproduce association between EMT-related markers and disease prognosis. Our results suggest that CAFs are the primary source of EMT signaling and have potential roles as biomarkers and targets for immuno-oncology therapies.
Experimental analysis of recommended corneal incision sizes in cataract surgery using 13 intraocular lens injector systems
Authors: Friedrich Maximilian , Auffarth Gerd U. , Merz Patrick R.
Published: February 2023

Smaller corneal incisions in cataract surgery are linked with a better visual outcome and less frequent postoperative endophthalmitis. The insertion of intraocular lens (IOL) injector systems into the anterior chamber of the eye to implant an IOL is associated with incision enlargement (IE) impeding these positive effects. The aim of this study was to compare manufacturers’ recommended incision sizes (IS) of 13 different intraocular lens injector systems in regard of intraoperative IE and postoperative IS. In total, 499 corneal incisions in ex vivo porcine eyes were analyzed. The preoperative ISs depended on the recommended IS of the examined injector system. The IS was measured right before and after IOL injector insertion with an incision gauge set. There was intraoperative IE in 87% of the incisions with a mean IE of 0.26 ± 0.18 mm. IE was often significantly larger in small IS compared to larger IS concerning an injector system (P < 0.05). Five injector systems needed to have a significantly larger IS than the manufacturers’ recommended IS with an average difference of 0.3 mm when applying study criteria (P < 0.05). Thus, the present study shows that IS recommendations require to be critically analyzed by ophthalmic surgeons to enable evidence-based practice.
Therapeutic efficacy of programmed spatial anatomy of the myopectineal orifice in total extraperitoneal hernioplasty: a retrospective study
Authors: Zhuang Lin , Li Yuanjiu , He Wei , Zhou Xiaodong , Chen Yan , Wang Xiaozhong , Wang Bo , Xu Xuezhong , Wu Kejia , Zhang Qiutao , Xi Dong , Lu Yunjie
Published: February 2023

This study aimed to investigate the therapeutic efficacy of programmed spatial anatomy of myopectineal orifice technique in laparoscopic total extraperitoneal hernioplasty (TEP) surgery. A total of 121 adult male patients with unilateral inguinal hernias who underwent TEP in the Department of General Surgery, Wujin Hospital, affiliated with Jiangsu University, from January 2019 to December 2020 were selected. Patients were divided into the procedural (63 cases) and traditional groups (58 cases) according to the surgical methods adopted. The procedural group underwent programmed spatial anatomy of the myopectineal orifice combined with TEP, and the traditional group underwent traditional TEP. The perioperative evaluation indicators and postoperative complications were observed and compared between the two groups. Compared with the traditional group, the time of handling hernia, the intraoperative operation time, intraoperative blood loss, postoperative ambulation time, and postoperative hospital stay in the procedural group were significantly reduced (P < 0.05). The incidence of postoperative complications such as sensory nerve abnormalities and chronic pain was significantly decreased (P < 0.05), and the total incidence of complications in the procedural group was significantly lower than that in the traditional group (P < 0.05). While there was no significant difference in postoperative incision infection (P > 0.05). The programmed spatial anatomy of the myopectineal orifice can significantly improve the treatment outcome of TEP, significantly improve the patients' intraoperative and postoperative indicators, and reduce the incidence of postoperative complications. It is worthy of being promoted among young physicians and basic hospitals.
Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament
Authors: Okuwaki Shun , Funayama Toru , Koda Masao , Eto Fumihiko , Yamaji Akihiro , Yokogawa Noriaki , Sasagawa Takeshi , Ando Kei , Nakashima Hiroaki , Segi Naoki , Watanabe Kota , Nori Satoshi , Takeda Kazuki , Furuya Takeo , Yunde Atsushi , Nakajima Hideaki , Yamada Tomohiro , Hasegawa Tomohiko , Terashima Yoshinori , Hirota Ryosuke , Suzuki Hidenori , Imajo Yasuaki , Ikegami Shota , Uehara Masashi , Tonomura Hitoshi , Sakata Munehiro , Hashimoto Ko , Onoda Yoshito , Kawaguchi Kenichi , Haruta Yohei , Suzuki Nobuyuki , Kato Kenji , Uei Hiroshi , Sawada Hirokatsu , Nakanishi Kazuo , Misaki Kosuke , Terai Hidetomi , Tamai Koji , Shirasawa Eiki , Inoue Gen , Kakutani Kenichiro , Kakiuchi Yuji , Kiyasu Katsuhito , Tominaga Hiroyuki , Tokumoto Hiroto , Iizuka Yoichi , Takasawa Eiji , Akeda Koji , Takegami Norihiko , Funao Haruki , Oshima Yasushi , Kaito Takashi , Sakai Daisuke , Yoshii Toshitaka , Ohba Tetsuro , Otsuki Bungo , Seki Shoji , Miyazaki Masashi , Ishihara Masayuki , Okada Seiji , Imagama Shiro , Kato Satoshi
Published: February 2023

Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological severity and improvement of CSCI in older patients. This multicenter retrospective cohort study identified 1512 patients aged ≥ 65 years diagnosed with CSCI on admission during 2010–2020. We analyzed CSCI etiology in OPLL patients. We performed propensity score-adjusted analyses to compare neurological outcomes between patients with and without OPLL. Cases were matched based on variables influencing neurological prognosis. The primary neurological outcome was rated according to the American Spine Injury Association (ASIA) impairment scale (AIS) and ASIA motor score (AMS). In 332 OPLL patients, the male-to-female ratio was approximately 4:1. Half of all patients displayed low-energy trauma-induced injury and one-third had CSCI without a bony injury. Propensity score matching created 279 pairs. There was no significant difference in the AIS grade and AMS between patients with and without OPLL during hospitalization, 6 months, and 12 months following injury. OPLL patients tended to exhibit worse neurological findings during injury; nevertheless, OPLL was not associated with poor neurological improvement in older CSCI patients.
A maximum entropy approach for the modelling of car-sharing parking dynamics
Authors: Daniotti Simone , Monechi Bernardo , Ubaldi Enrico
Published: February 2023

The science of cities is a relatively new and interdisciplinary topic aimed at studying and characterizing the collective processes that shape the growth and dynamics of urban populations. Amongst other open problems, the forecast of mobility trends in urban spaces is a lively research topic that aims at assisting the design and implementation of efficient transportation policies and inclusive urban planning. To this end, many Machine-Learning models have been put forward to predict mobility patterns. However, most of them are not interpretable -as they build on complex hidden representations of the system configurations- or do not allow for model inspection, thus limiting our understanding of the underlying mechanisms driving the citizen’s daily routines. Here, we tackle this problem by building a fully interpretable statistical model that, incorporating only the minimum number of constraints, can predict different phenomena arising in the city. Using data on the movements of car-sharing vehicles in several Italian cities, we infer a model using the Maximum Entropy (MaxEnt) principle. The model allows for an accurate spatio-temporal prediction of car-sharing vehicles’ presence in different city areas and, thanks to its simple yet general formulation, to precisely perform anomaly detection (e.g., detect strikes and bad weather conditions from car-sharing data only). We compare the forecasting capabilities of our model with different state-of-the-art models explicitly made for time-series forecasting: SARIMA models and Deep Learning Models. We find that MaxEnt models are highly predictive, outperforming SARIMAs while having similar performances of deep Neural Networks - but with advantages of being more interpretable, more flexibile—i.e., they can be applied to different tasks- and being computationally efficient. Our results show that statistical inference might play a fundamental role in building robust and general models describing urban systems phenomena.
Comparing the effects of highly aspherical lenslets versus defocus incorporated multiple segment spectacle lenses on myopia control
Authors: Guo Hui , Li Xianfang , Zhang Xiaoxiao , Wang Haizhao , Li Jianhua
Published: February 2023

To compare spectacle lenses with highly aspherical lenslets (HAL) versus defocus incorporated multiple segments (DIMS) on myopia progression control in 1 year. This retrospective cohort study involved data from children prescribed HAL or DIMS spectacle lenses in Guangzhou Aier Eye Hospital, China. To address the discrepancy that some children followed up at less than or more than 1 year, the standardized 1-year spherical equivalent refraction (SER) and axial length (AL) changes from baseline were calculated. The mean differences in the changes between the two groups were compared with linear multivariate regression models. Age, sex, baseline SER/AL, and treatment were included in the models. A total of 257 children who qualified for the inclusion criteria were included for the analyses (193 in the HAL group and 64 in the DIMS group). After controlling baseline variates, the adjusted mean (standard error, SE) of the standardized 1-year changes in SER for HAL and DIMS spectacle lens users were − 0.34 (0.04) D and − 0.63 (0.07) D, respectively. HAL spectacle lenses reduced myopia progression by 0.29 D (95% confidence interval [CI] 0.13 to 0.44 D) at 1 year compared to DIMS lenses. Accordingly, the adjusted mean (SE) ALs increased by 0.17 (0.02) and 0.28 (0.04) mm for children wearing HAL lenses and DIMS lenses, respectively. HAL users had 0.11 mm less AL elongation (95% CI − 0.20 to − 0.02 mm) than DIMS users. Age at baseline was significantly associated with AL elongation. Chinese children wearing spectacle lenses designed with HAL had less myopia progression and axial elongation than those wearing spectacle lenses designed with DIMS.
Degenerate and non-degenerate all-optical switches using violet phosphorus nanosheets
Authors: Gao Yang , Hu Yueqiu , Ling Cheng , Rui Guanghao , He Jun , Gu Bing
Published: February 2023

In this work, SSPM effects of VP Ns and their reaction dynamics were studied for the first time (left). Using the superior coherence electronic nonlinearity of VP Ns, all-optical switches based on the SSPM effect (right) were prepared.
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions
Authors: Somavarapu Arun Kumar , Kleijwegt Giulia , Nagaraj Madhu , Alam Parvez , Nielsen Janni , Otzen Daniel E.
Published: February 2023

The toxic α-synuclein oligomer (αSO) is an important drug target. Neuronal proteins found by pull-down assays do not bind αSO in solution. A liposome assay identifies 7 drugs reducing αSO membrane disruption, of which 2 disrupt αSO-antibody binding.
Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for
Polycystic Ovary Syndrome Women with Insulin Resistance
Authors: Zhao Manyin , Li Yangyang , Zhang Yifan , Wang Xiaojie , Wang Xinshu
Published: February 2023

Polycystic ovary syndrome (PCOS) is the most common disease caused by complex
endocrine and metabolic abnormalities in women. Insulin resistance is considered
an important pathophysiological factor in the pathogenesis of PCOS. Here we
investigated the clinical values of C1q/TNF-related protein-3 (CTRP3) as
predictive factor for insulin resistance. Our study included 200 patients with
PCOS, among which 108 had insulin resistance. Serum CTRP3 levels were measured
using enzyme-linked immunosorbent assay. Predictive values of CTRP3 for insulin
resistance was analyzed using receiver operating characteristic (ROC) analysis.
Correlations of CTRP3 to insulin levels, obesity measurements and blood lipid
levels were determined using Spearman’s correlation analysis. Our data
suggested that PCOS patients with insulin resistance had a higher obesity, lower
high-density lipoprotein cholesterol, higher total cholesterol, higher insulin
levels and lower CTRP3 levels. CTRP3 had a high sensitivity (72.22%) and
specificity (72.83%). CTRP3 significantly correlated to insulin levels,
body mass index, waist-to-hip ratio, high-density lipoprotein, and total
cholesterol levels. The predictive value of CTRP3 in PCOS patients with insulin
resistance was supported by our data. Our findings suggest that CTRP3 is
involved in the pathogenesis and insulin resistance of PCOS, which indicates its
value as an indicator for the PCOS diagnosis.
Challenges in Complex Oncological Chest Wall Reconstruction with Free Anterolateral Thigh Flap and Titanium Rib Plate
Authors: Chai Cheng Siew , Shamugam Kasthuri , Basiron Normala Binti , Zain Mohammad Ali Bin Mat , Zainal Hamidah Binti , Luen Koh Khai , Sathiamurthy Narasimman , Chai Diong Nguk , Pandian Benedict Dhamaraj A.L. Retna
Published: February 2023

Extensive chest wall tumor resection and reconstruction possess a formidable challenge and require good collaboration between thoracic and reconstructive surgeons. In this article, we reviewed our experience in six consecutive cases requiring complex chest wall resection and reconstruction with titanium rib plates and free anterolateral thigh fasciocutaneous flap with fascia lata with a minimum 24 months follow-up postoperatively.

Six patients with a mean age of 54 were diagnosed to have locally advanced malignant (n = 5) and benign (n = 1) tumors. They underwent wide local excision with a mean of six ribs resected, and the average size of the soft tissue defect was 389cm2. The integrity of the thoracic cage was restored by using titanium rib plates. Fascia lata was harvested along with free anterolateral thigh fasciocutaneous flap to achieve near airtight closure of pleural space for soft tissue coverage. Two patients required early flap exploration with successful flap salvage. One flap failure was reported on postoperative day 11 due to a mechanical cause and a redo surgery was required. With an average stay of 3 days in the intensive care unit, no perioperative pulmonary complications were recorded.

Complex oncological chest wall resection and reconstruction with titanium rib plates and free anterolateral thigh fasciocutaneous flap with fascia lata yielded satisfactory aesthetic and physiological functional outcomes.
First Case Report of Breast Implant Associated-Anaplastic Large Cell Lymphoma from India: Are We Ready?
Authors: Khanna Soumya , Choudhary Sunil , Mantri Raghav , Arora Prateek , Arya Anupama , Bansal Richa , Grewal Preeti , Bhardawaj Nishu
Published: February 2023

Breast implant associated-anaplastic large cell lymphoma (BIA-ALCL) has become a hot topic in recent plastic surgery and oncology forum. Its cases have been on the rise since its first emergence more than two decades ago. This condition is less known and management guidelines are still evolving. BIA-ALCL was seen recently with a classical presentation in one of our patients, who underwent immediate reconstruction with a macro-textured silicone implant following breast cancer surgery. We want to add the first case report from India to the global information database. There are still unanswered questions in its management, and we wish to highlight the same to make way for further research. With the rise in aesthetic and reconstructive implant surgeries, the knowledge of BIA-ALCL must expand among oncologists, radiologists, and pathologists for early identification and treatment for better patient outcomes.
Investigating bouncing water droplets with high speed cameras
Authors: Johnson-Groh Mara
Published: February 2023

Results determined the upper limit for the impact velocity of bouncing droplets on micro-grooved surfaces.
Minimum-modified Debye-Hückel theory for size-asymmetric electrolyte solutions with moderate concentrations
Authors: Xiao Tiejun , Zhou Yun
Published: February 2023

A minimum-modified Debye-Hückel (DH) theory for electrolytes with size asymmetry is developed. Compared with the conventional DH theory, the minimum-modified DH theory only introduces an extra surface charge density to capture the electrostatic effect of the size asymmetry of the electrolytes and hence facilitates a boundary element method for electrostatic potential calculation. This theory can distinguish the electrostatic energies and excess chemical potentials of ions with the same sizes but opposite charges, and is applied to a binary primitive electrolyte solution with moderate electrostatic coupling. Compared with the hyper-netted chain theory, the validity of this modified DH theory demonstrates significant improvement over the conventional DH theory.
Preparation and supercapacitive performance of CuFe2O4 hollow-spherical nanoparticles
Authors: Zhang Yu , Zhu Qingguang , Zhao Yaqi , Yang Xin , Jiang Ling
Published: February 2023

Spinel-type CuFe2O4 nanoparticles were synthesized by a solvothermal method using ethylene glycol as solvent and polyvinylpyrrolidone (PVP) as dispersant. The characterization results showed that the average diameter of the hollow-spherical CuFe2O4 was approximately 100 nm with homogeneous morphology and negligible agglomeration. CuFe2O4 was used as the active electrode material to explore its supercapacitive properties in different concentrations of KOH electrolytes. It was found that the CuFe2O4 hollow-spherical nanoparticles exhibit potential electronic performance in supercapacitor, with a specific capacitance of 368.2 F/g and capacitance stability retention of 91.0% after 2000 cycles at the current density of 5 A/g in 3 mol/L KOH electrolyte. The present findings demonstrate that the CuFe2O4 electrode materials can have important implications with practical prospects in energy storage systems.
‘Common nighthawk’ (Chordeiles minor) in Algonquian and Siouan languages
Authors: Collette Vincent
Published: February 2023

Some North American indigenous languages have names for ‘common nighthawk’ (Chordeiles minor)’, ‘robin’, and ‘bird’ that are strikingly similar phonetically and have served to advocate long-distance genetic relationships among language families. While the Algonquian proto-form for ‘nighthawk’ has a rather straightforward pedigree, this is not the case for Siouan languages. Despite their phonetic resemblance, the ornithonyms for ‘nighthawk’ in half a dozen Siouan languages are unrelated; some are mimetic innovations and others are borrowed. This article analyses how and why ornithonyms are problematic in the application of the comparative method, a reality that affects the validity of long-distance claims, and offers alternative ways to deal with this issue. While ornithonyms can be inherited and undergo all the regular sound changes (or not) like other words, they are also problematic in many respects. First, they can be onomatopoetic and imitate the cry or call of the bird in question – a feature that accounts for their cross-linguistic similarity. Second, they can undergoad hocmimetic reshaping or become lexically contaminated based on phonetic similarity with other ornithonyms or words with which they are associated culturally. Third and last, they can be borrowed internally or externally. However, despite these comparative pitfalls (i.e., that some phonetically similar forms in a language family are not cognates), the analysis shows that our understanding of ornithological nomenclature can be enhanced by considering elements of ornithology, mythology, ethnographic knowledge, sayings, and puns pertaining to birds.
Race and Decolonization in North Africa
Authors: Davis Muriam Haleh
Published: February 2023

The precolonial history of slavery is fundamental for understanding the roots of antiblack racism in the region known as the Maghreb. At the same time, the question of skin color does not capture the diverse forms of discrimination that have been experienced by populations in the region over the last two hundred years. French colonial officials, for example, upheld the Berber population as a separate race that was inherently more civilized and less Muslim than the Arab population. Jews in Algeria were offered French citizenship in 1870, further complicating the racial formation of the colonial Maghreb. Despite colonial attempts to posit a racial difference between so-called white and black Africa, the porous geographical boundaries in the southern regions of the Sahara made it difficult to assert a clear distinction between Arab and African peoples. After independence, Algeria, Morocco, and Tunisia sought to foster a coherent national identity and achieve political legitimacy, and their experiences of state building in turn influenced how religious and ethnic minorities were treated after independence.
Diversity of yeasts in Indian fermented foods and alcoholic beverages
Authors: Tamang Jyoti Prakash , Lama Sonam
Published: February 2023

Ethnic Indian people have been domesticating beneficial microorganisms (bacteria, yeasts, and moulds) by their wisdom of ethno-microbiological knowledge for production of flavoured and socio-culturally preferred fermented foods and alcoholic beverages for more than 8000 years. The purpose of this review is to collate the available literatures of diversity of Saccharomyces and non-Saccharomyces species associated with Indian fermented foods and alcoholic beverages. A colossal diversity of enzyme- and alcohol-producing yeasts under the phylum Ascomycota has been reported from Indian fermented foods and alcoholic beverages. The distributions of yeast species show 13.5% of Saccharomyces cerevisiae and 86.5% of some non-Saccharomyces spp. in Indian fermented foods and alcoholic beverages, based on the reported literatures available till date. There is a research gap on prospect of yeasts research in India. Hence, we suggest that validation of traditional knowledge of domestication of functional yeasts needs to be studied to develop the functional genomics platforms for Saccharomyces and non-Saccharomyces spp. in Indian fermented foods and alcoholic beverages.