bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Effect of Knowledge, Attitudes, and Support on the Preparedness of the Team for Exceptional Events and Outbreaks at Public Health Center the Bengkulu Province
Authors:   Widyaiswara Ahli Madya UPTD Pelatihan Kesehatan Bengkulu, Yandrizal Yandrizal , Yulinar Yulinar ,   Widyaiswara Ahli Madya UPTD Pelatihan Kesehatan Bengkulu
Published: December 2022

Background: Community Extraordinary events need to be anticipated by preparing a team to respond quickly to exceptional circumstances and outbreaks at each health center, and it is necessary to increase the capacity of the special personnel of the Rapid Action Team (RAT). What is the preparedness of the fast-moving team to respond to the prevention and control of outbreaks at the Public Health center. Materials/Methods: Quantitative research with a cross-sectional approach was implemented to determine the effect of knowledge, attitude, and support on the preparedness of the Team for Extraordinary Events in Health Centers in Bengkulu Province. The population of the Rapid Action Team training participants was 10 batches. A sample of 153 respondents, analysis of linear and multiple regression data using SPSS 22 to analyze the effect of knowledge, attitudes, and support on the preparedness of the TGC Team. Result: The team must prepare themselves by compiling and training in applying standard operating procedures (SOP) for handling extraordinary events for each disease that can potentially be an exceptional circumstance (KLB). The fast-moving team must prepare themselves by conducting simulations to find out their readiness by evaluating each simulation result to improve the team's preparedness. The fast action team (RAT) for handling outbreaks and outbreaks at the Puskesmas is a policy that must be established by the decision of the authorized official. Conclusion: The Rapid action team (RAT) for handling extraordinary events and outbreaks at the Public health center is a policy that must be established by the decision of the authorized official so that it is more motivated and facilitates the need for Team preparedness for Extraordinary Events (KLB). The team is expected to carry out routine simulations for team preparedness in handling extraordinary events.
Left Dermoid Ovarian Cyst in a Woman with Term Pregnancy on the Bi-Scar Uterus
Authors:   Yangambi Higher Institute of Medical Techniques (ISTM-YBI), LIANDE Ley BAFENO , KUMIELE Paul MANGASA ,   Yangambi Higher Institute of Medical Techniques (ISTM-YBI), LOKANGU Zénon BAOMBOLIA ,   Yangambi Higher Institute of Medical Techniques (ISTM-YBI), ISANONGO Daniel MBISA ,   Higher Institute of Medical Techniques of Kisangani (ISTM-KIS), LIFONGO Didier LOKE ,   Yangambi Higher Institute of Medical Techniques (ISTM-YBI), LEKADIANO Joséphine ,   General Reference Hospital MAKISO-KISANGANI, ZOLA Aimé ,   General Reference Hospital MAKISO-KISANGANI, OKETA Gabriel ,   General Reference Hospital MAKISO-KISANGANI, NYEMBO Chico MUDIMBI ,   General Reference Hospital MAKISO-KISANGANI, LOMBE Bobo FOLO ,   General Reference Hospital MAKISO-KISANGANI
Published: December 2022

Ovarian dermoidal cysts are benign lesions arising from germ cells. If they are large, they can pose a problem of differential diagnosis with the hydatid cyst. Transformation to a malignancy is possible. Complications are numerous, going as far as peritonitis or even fistulization in a hollow organ. We present a case of dermoid cyst of the ovary in a 33-year-old parturient with twice scarred uterus who was treated surgically and whose postoperative evolution was good.
Epidemiological and Clinical Profile of Cranio-Encephalic Trauma (TCE) at the Inera Yangambi General Hospital
Authors:   Higher Institute of Medical Techniques of YANGAMBI (ISTM – YBI), LYANDE Ley BAFENO , ISONONGO Daniel MBISA ,   Higher Institute of Medical Techniques of KISANGANI (ISTM – KIS), BOENGA Georges LISUNGI ,   Higher Institute of Medical Techniques of YANGAMBI (ISTM – YBI), KOLAWINA Charles BOYEMBA ,   Higher Institute of Medical Techniques of YANGAMBI (ISTM – YBI), ILANGA BOTOMOITO ,   Higher Institute of Medical Techniques of YANGAMBI (ISTM – YBI), MIABO Raphael SHABANI ,   Higher Institute of Medical Techniques of YANGAMBI (ISTM – YBI)
Published: December 2022

Cranio-encephalic trauma represents a 30-millisecond event, the leading cause of death or severe disability in young adults. It is therefore necessary to determine the nature and extent of the lesions as quickly as possible because the situation can deteriorate very quickly in the following days. Overall mortality remains heavy and sequelae frequent, which poses the problem of socio-professional and family reintegration. At the end of this study, we arrived at the following results: The prevalence of patients with cranio-encephalic trauma admitted to the General Hospital of INERA YANGAMBI was 44.5% during the period of our study; Most of our patients were male with 68.4%; The 20 to 29 age group was more affected; The students were more victims of cranio-encephalic trauma ; Road traffic accidents are the main etiology of cranio-encephalic trauma with 4% of cases in our research environment; The abrasion was the most observed anatomo-pathological lesion with 3% ; The majority of our patients had a clear conscience on admission with 72.5%; the evolution of the majority of patients was marked by an improvement with 2%
Graham’s Patch Repair for Peptic Perforation : A Review
Authors:   General Practicioner, Ananda General Hospital, Purwokerto, Indonesia, Wandantyas Elena , Winoto Singgih ,   Surgeon Specialist, Ananda General Hospital, Purwokerto, Indonesia, Sakti Yuhantoro Budi Handoyo ,   Surgeon Specialist, Ananda General Hospital, Purwokerto, Indonesia, Department of Surgery, Faculty of Medicine, Muhammadiyah University, Purwokerto, Indonesia
Published: December 2022

Introduction : Frequently monitored, occurrences of peptic perforation due to a variety of etiologies are still frequently discovered. The surgical Graham Patch Repair technique is still regarded as having a respectable level of accuracy and profitability. Methods : The PubMed literature search engine's advanced search feature was utilized to find literature review papers for this journal. Selected periodicals from which writing was based were collected. Result Peptic perforation can occur under a variety of circumstances, and both the Graham technique and the Modified Graham Patch repair are recommended. The benefit of using the best Graham approach is that it promotes quick wound healing while lowering morbidity and mortality. Conclusion : Peptic perforation can occur in a variety of medical conditions, yet in these cases the Graham technique can still be recommended. Different surgical treatments regularly have unanticipated consequences, necessitating their modification or even combination in order to preserve the patient's life while also reducing prospective problems in the future.
The Covid-19 Antibody Titer of Convalescence Plasma Repeated Donors at Red Cross Indonesia of Tulungagung Regency
Authors:   Blood Bank Technology Study Program, Applied Health Science Department, Poltekkes Kemenkes Malang, Indonesia, Sudiwati Ni Luh Putu Eka , Kusuma Rachmadi Yuwana ,   Blood Bank Technology Study Program, Applied Health Science Department, Poltekkes Kemenkes Malang, Indonesia, Panggayuh Ardi ,   Blood Bank Technology Study Program, Applied Health Science Department, Poltekkes Kemenkes Malang, Indonesia, Ariani Nia Lukita ,   Blood Bank Technology Study Program, Applied Health Science Department, Poltekkes Kemenkes Malang, Indonesia
Published: December 2022

Convalescent plasma is plasma that is already present in the body and includes anti-SARS-CoV-2 antibodies. This plasma includes antibodies that may kill viral particles, thereby preventing virus entrance into cells. This neutralizing procedure has an effect on the improvement of a patient's clinical state after receiving convalescent plasma treatment. The possibility of this convalescent plasma therapy as a treatment for individuals infected with SARS-CoV-2 has been evaluated, and clinical trials are still ongoing. The aim of this study is to determine the antibody titer of the donor. The research was a descriptive study. Total sample was 25 repeated male donors. The data of their IgM and IgG levels was obtained from Management Information System at Red Cross Indonesia Of Tulungagung Regency. Data was presented as table. The mean IgG level of repeated convalescent plasma donors is higher than the mean IgM level. The mean IgM level of repeated convalescent plasma donors is often constant. The mean IgG level of convalescent plasma donors increased through the fifth donor and then declined from the sixth to the ninth donor. The mean result of IgM and IgG has decreased by a higher proportion than it has increased.
A Descriptive Study of Reporting of breast Fine Needle Aspirationcytology Using International Academy of Cytology Yokohama System
Authors:   M.D. Pathology (Resident), Department of Pathology, SMS Medical College, Jaipur (Rajasthan), Meena Dr. Akhilesh Singh , Agnani Dr. Bhawna ,   M.D. Pathology (Senior Medical Officer), Department of Pathology, SMS Medical College, Jaipur (Rajasthan), Hemrajani Dr. Deepika ,   M.D. Pathology (Professor), Department of Pathology, SMS Medical College, Jaipur (Rajasthan)
Published: December 2022

Background: The International Academy of Cytology (IAC) has established standardizedapproach for reporting breast FNAC by categorizing lesions in a five-tier system from C1 to C5. Materials and Methods: From May 2020 to April 2021, a descriptive cross-sectional study was conducted in the cytology section of the Department of Pathology, SMS Medical College, Jaipur. Results: The current study involved 335 cases of breast FNAC, with a maximum of 333 (99.40%) females and 2 (0.60%) males. Maximum cases were in the age range of 21-40 years. There were 79 (23.60%) cases in C1 (Insufficient) category, C2 (Benign) had 177 (52.80%) cases, C3 (Atypical) had 9 (2.70%) cases, C4 (Suspicious) had 16 (4.80%) cases, and C5 (Malignant) had 54 (16.10%) cases respectively. Fibroadenoma was the most prevalent benign lesion in our analysis, accounting for 45 of the 177 benign cases, whereas ductal carcinoma was the most common malignant lesion.In a total of 92 cases where histology was examined, 86 cases were found to be compatible with the cytological diagnosis. In a triple assessment, 103 (78.03%) of the 132 cases were concordant in the benign group, only 1 (12.50%) case showed concordance in the atypia category, and 21 (39.62%) of the 53 cases showed concordance in the suspicious or malignant category. The Risk Of Malignancy (ROM) was calculated as follows: inadequate 0%, benign 0%, atypia 0%, suspicious for malignancy 71.43%, and malignant 97.56% for each group. Conclusion: This system is a valuable tool for breast cancer patient diagnosis and care. It also simplifies clinical audits and aids in improved coordination between pathologists, hospitals, and institutes.
Idiopathic Solar Dermatitis: A Literature Review
Authors:   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México, Vizcano Jacqueline Avalos , López César Rubén Pérez ,   Universidad de Guanajuato. Guanajuato, México, Parra Nuño Erick Israel ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México, Atenas Arteaga Bruno Leslie ,   Universidad Hipócrates. Acapulco de Juárez, Guerrero, México, Figueroa María Cristina Ponce ,   Instituto de Estudios Superiores de Tamaulipas (IEST Anáhuac). Tampico, Tamaulipas, México, Bonilla Nayeli Guadalupe González ,   Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud. Guadalajara, Jalisco, México
Published: December 2022

Idiopathic solar dermatoses represent a group of diseases in which a chromophore endogenous is modified by the action of ultraviolet radiation and triggers clinical pictures characteristic. The most common of these entities is the polymorphic solar eruption, which represents one third of all photodermatosis. The study of idiopathic solar dermatoses is important, since they are frequent entities, have a negative in the quality of life of the patient and show characteristics similar to other skin diseases. An adequate diagnosis is crucial to determine the therapeutic approach, although on some occasions it may have spontaneous resolution. Photodermatoses are skin diseases produced by the action of electromagnetic radiation on the skin, either in the ultraviolet spectrum or in the range of visible light. A guest is required for your presentation immunologically susceptible.
The Correlation Between Environment-Based Curriculum and Teacher Pedagogical Competence with Learning Quality through Literacy Learning at State Junior High Schools in East Banjarmasin District
Authors:   Master of Education Administration, Lambung Mangkurat University, Banjarmasin, Indonesia, Aprianti Ayu , Suriansyah Ahmad , Syaifuddin Agus Rifani ,   Master of Education Administration, Lambung Mangkurat University, Banjarmasin, Indonesia
Published: December 2022

This study aims to analyze the direct and indirect correlation between environment-based curriculum, teacher pedagogical competence and learning quality through literacy learning. This research used a correlational study with a quantitative approach. Two hundred and eighteen junior high school teachers at adiwiyata schools were involved as population of this study. The researchers used proportional random technique and obtained as many as 141 people. The data collection was carried out using instruments consisting of an environment-based curriculum (17 items), teacher pedagogic competence (21 items), literacy learning (13 items) and learning quality (29 items). The validity and reliability tests were performed using the Alpha Cronbach. Then, the data of this study was analyzed using descriptive statistics with path analysis to see direct and indirect correlations between variables, by first carrying out the normality test, homoscedasticity test, multicollinearity test and correlation test. The results of the study show that there is a correlation between: (1) environment-based curriculum and learning quality, (2) teacher pedagogic competence and learning quality, (3) literacy learning and learning quality, (4) environment-based curriculum and literacy learning, (5) competency teacher pedagogy with literacy learning, (6) the correlation between environmentbased curriculum and learning quality through literacy learning, (7) the correlation between teacher pedagogic competence and learning quality through literacy learning
Physical–Mechanical Properties and Dimensions of Cotton Rows
Authors:   Acting Associate Professor, Bukhara Institute of Natural Resources Management of the National Research University of TIIAME, Abdualiev Nuriddin Khabibovich
Published: December 2022

Studying the physical–mechanical properties of the soil is one of the important issues when basing the parameters of the device that softens the knot between cotton rows. At the same time, it is necessary to determine these properties when studying the effect of the device on energy and quality indicators. The physical, mechanical and technological properties of the soil (soil moisture, density and hardness) were studied in 0–15 cm layers at intervals of 5 cm according to GOST 20915–2011. It can be seen that the physical and mechanical parameters of the soil increase as its depth increases. It was determined that soil moisture in the range of 0-15 cm varies in the range of 14.8–24.0% hardness, 0.13–0.38 MPa, and density in the range of 0.86–1.05 g/cm3. The moisture of the soil corresponds to the agrotechnical requirements for processing between rows of cotton.
Gastrointestinal and Nutrition Tables in Latest Gastrointestinal Research in Islamic Civilization in Middle Ages
Authors:   Islamic Azad University Central Tehran Branch, Shahidipak Mohammadreza
Published: December 2022

Research on Islamic civilization shows that gastrointestinal diseases are rooted in social lifestyles and are a sociological phenomenon. The science and craft of medicine evolved to such an extent that Muslim physicians presented a set of general rules in medicine, including gastroenterology, including Ibn Rushd in his book Generalities in Medicine. One of general laws of medicine in Middle Ages was about the functioning of gastrointestinal tract in relation to disease and health. In this general law, the systematic relationship between digestion and place, including village and city, time of year and days and hours of day and night, age of people, pollution and air pollution, is regulated in health table. By referring to this limit, one can choose food that is useful for maintaining health and also be safe from diseases. Spread of health is legacy of Islamic medicine in Middle Ages for world of science, which can be used even now. In this general law, occurrence of all diseases is due to digestive problems and incorrect choice of food. He considers urban lifestyle in nutrition as cause of all diseases. In Islamic medicine, there is a direct relationship between food and its type of digestion and lifestyle to maintain health. According to Ibn Khaldun, who has introduced himself as a commentator on works of Averroes who invented eight hundred years ago the “Trophology and “Ecotrophology” which developed in Europe in second half of twentieth century, was ago, Ibn Khaldun as sociologist studied issue pathology of nutrition from propht to averroes and interoduced hypotheses in nutrition about view of Islamic civilization and writes: Urban diet style is cause of disease: 1. Wrong food composition. people of city add all kinds of ingredients and condiments to food and produce dozens of indistinct forms of food and fruit that are not recognizable to human temperament. 2. Inactivity among city dwellers. 3. Stinking air and air pollution 4. Overeating and starting to eat new food before digesting t previous food Research hypothesis is presentation of a panoramic image of human nutrition knowledge of Qur’an by human maker, which is a firm image and in accordance with reality and there is a firm and definite logical relationship between gastrointestinal tract and food and health that can be plotted in a quantitative graph in Islamic civilization.
Child Protection Through Intercountry Adoption in Malaysia: A Literature Review
Authors: A.Kadir Nadhilah , Mohd Azizah
Published: December 2022

Intercountry adoption is recognised at the international level as a child protection measure, particularly during the Second World War. The introduction of the Hague Convention on Protection of Children and Co-operation in Respect of Intercountry Adoption 1993 (Hague Convention 1993) has formally recognised intercountry adoption as one of the means of child care. However, in Malaysia, intercountry adoption is not formally practised and Malaysia is not a State party to the Hague Convention 1993. A review of intercountry adoption as a child protection measure in Malaysia from a legal perspective was conducted and four themes emerged, namely, (a) legal and policy framework; (b) legal issues; (c) sending and receiving states’ perspectives; and (d) Malaysian perspective. Results indicate that there is a comprehensive literature on intercountry adoption from a legal perspective but small literature in the context of Malaysia since it is not formally recognised as a child protection measure. At present, intercountry adoption is permitted based on the requirement of residence in the adoption statutes.
A Systematic Literature Review on the Implementation of E-Learning Platforms in the Covid-19 Pandemic
Authors: Kayyad Hakeem Almijlad Aliyah , Aldulaan Mohammed Salal
Published: December 2022

The covid-19 pandemic has escalated widely and gained attention among people throughout the world. The COVID-19 pandemic has brought an enormous impact on the lives of many people all over the world. It significantly affects various dimensions such as the economy, society, tourism, and education of many nations. Online classes were found demandable as an alternative to institutional closure during this unprecedented time. The successful implementation of e-Learning systems depends on how the program is perceived by students and instructors. The current review aimed to identify the global picture of e-learning during the COVID-19 pandemic and the perceptual difference among the world regarding online-based learning in the pandemic timeframe. 19 articles were selected for this review study. The findings of this review illustrated that although online teaching is one of the best possible ways to continue teaching and learning during the pandemic, student faces a lot of challenges in the use of online learning systems. The positive perception of students and lecturers has on the availability of strong technological infrastructure, adequate equipment, and professional training. The outcome of this review will help to improve the e-learning education policy such as a standard marking system, accessible internet network, and equipment for all students.
Peranan Kepimpinan Melayu Brunei dalam Pentadbiran BNBC di Borneo Utara (1881-1941)
Authors: Awang Jambol Dg. Junaidah , Hassan Nurulasyikin , Ang Kean Hua , Zakaria Zulayti
Published: December 2022

Makalah ini membincangkan tentang peranan kepimpinan Melayu Brunei dalam pentadbiran pada zaman British North Borneo Chatered Company (BNBC) di Borneo Utara dari tahun 1881 sehinggalah 1941. Makalah ini merupakan satu usaha untuk merekonstruksikan semula landasan penjelasan tentang penglibatan kepimpinan Melayu Brunei di dalam pentadbiran yang direncanakan oleh pihak BNBC. Kebanyakan sumber yang digunakan terdiri daripada sumber yang berkaitan dengan topik yang telah dibincangkan namun, telah diolah dan dinilai semula di dalam perspektif yang baharu. Makalah ini juga akan akan membincangkan peranan dan kaedah yang digunakan oleh pihak BNBC untuk menarik ketua-ketua tempatan khususnya kepimpinan Melayu Brunei untuk menyertai institusi peribumi dan seterusnya mengikat kesetiaan mereka dengan pihak syarikat. Menerusi kajian ini juga didapati bahawa pihak BNBC telah berjaya menemui formula yang berkesan bagi memastikan masyarakat peribumi khususnya masyarakat Melayu Brunei untuk mengikuti semua polisi dan dasar baharu yang ditetapkan oleh pihak BNBC sehingga akhirnya perubahan ini telah mempengaruhi keberadaan dan pengekalan kepimpinan Melayu Brunei dalam pentadbiran di Borneo Utara pada tahun-tahun berikutnya.
Knowledge, Attitude and Practice of Hand Hygiene Among Parents: A Post COVID-19 Pandemic Survey
Authors: Ramli Shalinawati , Azmi Anis Hafizah , Mohamed Nurul Azmawati , Mohd Rani Mohd Dzulkhairi
Published: December 2022

Hand hygiene is one of the effective measures to prevent infectious diseases such as hand, foot and mouth disease and COVID-19. Parents involvement as the child's first educator in establishing the child's sanitary behavior are crucial in nurturing good hand hygiene habit. This study aimed to assess parents' knowledge, attitudes, and practice on hand hygiene in relation to childcare during the endemic phase of COVID-19. This cross-sectional study involved parents of pre-school children from the Sepang district of Selangor, Malaysia. The parents were given a set of pre-tested, self-administered questionnaires about their knowledge, attitude, and practice of personal hand hygiene, hand hygiene practice while caring for children, and diseases caused by inadequate hand hygiene. A total of 179 parents, mostly (62%) were mothers with mean age of 37.55 (SD 21.2) involved in this study. The parents had good knowledge (99.4%), good attitude (92.7%) and good (100%) hand hygiene practice. Good attitude was significantly associated with good practice. Good knowledge, attitude, and practice on hand hygiene among parents might be due to repetitive information about the importance of hand hygiene during the COVID-19 pandemic. Efforts should be made to ensure teachers, children and parents are continuously being educated and reminded about hand hygiene not only during COVID-19.
Pengaruh Literasi Dan Tingkat Religiusitas Terhadap Minat Berwakaf Uang (Studi Kasus: Masyarakat Kabupaten Bima)
Authors: Maulana Syarif Hidayatullah  , Mujakir
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh literasi dan tingkat religiusitas terhadap minat berwakaf tunai pada masyarakat kabupaten Bima. Data dan informasi yang digunakan dalam penelitian ini menggunakan data primer yang diperoleh dari hasil pengisian kuesioner. Jenis data yang digunakan adalah kuantitatif dan menggunakan metode analisis regresi linier berganda dengan teknik pengambilan sampel menggunakan Simple Random Sampling. Hasil penelitian menunjukkan bahwa variabel literasi dan religiusitas masing-masing memiliki pengaruh yang signifikan terhadap minat berwakaf tunai pada masyarakat kabupaten Bima.
Faktor-Faktor yang Mempengaruhi Masyarakat Berwakaf Uang di Dompet Dhuafa
Authors: Imam Nurul , Huda Nurul
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh variabel eksogen terhadap variabel endogen dalam wakaf uang sehingga penelitian ini dapat menjadi acuan bagi lembaga wakaf uang agar wakaf uang dapat berkembang dan bermanfaat bagi kemaslahatan umat. dan buat datanya diolah menggunakan spss, aplikasi sem smart pls. Variabel dalam penelitian ini adalah religiusitas Islam, pengetahuan produk, kepercayaan dan minat konsumen memiliki hasil yang positif dan signifikan, maka solusi dari penelitian ini adalah lembaga atau pemerintah perlu melakukan edukasi dan sertifikasi nazhir wakaf secara berkala agar masyarakat Indonesia tertarik untuk melakukan wakaf. karena data dari masyarakat di Jakarta. Bogor Depok Tangerang, Bekasi, masih banyak yang belum paham tentang wakaf uang
Проектирование, разработка и оценка экономической эффективности компонента информационной системы производственного предприятия
Authors: Гумерова Г.Р., , Абдуллина Э.И.
Published: December 2022

В монография представлены результаты совершенствования управления технологической подготовкой производства – проекта автоматизации учета специнструмента и технологической оснастки производственного предприятия. Структура охватывает этапы предпроектного анализа объекта исследования, проектирования и разработки. В конце представлена оценка экономической эффективности реализации.
Efficacy and Safety of Intralesional Bleomycin for Treatment of Lymphangioma: Report from a Tertiary Care Hospital of Bihar
Authors: Nawaz Dr. MD Sarfaraz , Anand Dr. Aditya , Shubham Dr. Kumar
Published: December 2022

Background: Lymphangioma is a benign tumor of lymphatic vessels, with 75% cases occurring in head and neck. Surgical excision is the traditional management. Intralesional sclerotherapy has become a method of treatment for lymphangiomas in children. A retrospective clinical trial was conducted to evaluate the efficacy of intralesional bleomycin sclerotherapy (IBS) in the treatment of lymphangiomas in children. Methodology: A prospective study was conducted by the Department of General Surgery of MGM Medical College, Kishanganj, Bihar. Study was commenced after getting the ethical approval from the Institutional ethical committee. The period of data collection was 2 years that is from October 2019 to September 2021. The response of IBS was assessed clinically and on the basis of color Doppler USG. Results: 36 patients of lymphangioma were included in the study. 63.9% patients were seen before 1 year of age. Of all, 75% of the cases that is 27 patients had cystic hygroma, 3 were cavernous, and 6 were of mixed type. The neck region was the most common site with 25 (69.4%) patients. 19.4% required single dose. 11 patients developed side effects. Conclusion: Complications can also occur postoperatively o
Contemporary Modernization in the Domain of Microneedles
Authors: Priyanka. E Sai , K Srinivasa Reddy.
Published: December 2022

Microneedle arrays are one of the most predominant ways to produce desired bioavailability by transdermal delivery of the drugs. Microneedles are considered idea-inspiring technology which enchanted numerous scientific researchers. They are designed as most intrude and cause minimal pain which protrudes into the stratum corneum. These are some of the most evolving techniques compared to the other subcutaneous injections. They are micron scaled needles that are non-invasive, painless, causes less infection or injury with excellent skin permeability to a wide range of compounds viz., small molecular weight drugs, oligonucleotides, proteins thereby considering microneedles as third-generation transdermal drug delivery systems as they serve as a great platform for selfadministration of drugs. Targeting a medicine to a specific skin location allows for desired drug administration. Moreover, a lot of research is being carried out that solves various obstacles to successfully launching microneedles into the market. This review provides in-depth information on microneedles, types, materials and methods, and emerging applications and summarises innovations of smart MNs describing magnificent functions.
Articulation Expansion including Artificial Insemination Estimation of Dextromethorphan Tablet by Solid Dispersion Recipe for Solubility Enhancement
Authors: Hussain Dr Zakir , Suresh Dr Mukkamalla , Hemalata B. , Shireen Shaik
Published: December 2022

The concept of formulating sustained release tablets using different polymers offers a suitable and practical approach of sustained in release and dissolution characteristics. Here the solubility of Dextromethorphan is enhanced by solid dispersions with PEG6000 as carrier. Then the formed solid dispersions are characterized and evaluated by drug content and In vitro dissolution studies. Among the various s solid dispersions prepared, the formulation SDF2 i.e., the solid dispersion of Dextromethorphan with PEG6000 prepared by Solvent Evaporation method shows faster dissolution rate it was decided to use formulations SDF2 to formulate sustained release tablets using different polymers like HPMC, EC and Guar gum by direct compression technique. Optimized formulation F4 which includes HPMC and EC has successfully sustained the drug release. The release process involves anomalous diffusion mechanism or diffusion coupled with erosion. FTIR studies show that there is compatibility between drug and excipients for the developed matrix tablets.
Formulation, Development and Optimization of Nanocarriers for Skin Disorder Luliconazole Gel
Authors: Singh Manish Kumar , Kumar Dr. Sachin
Published: December 2022

The present look at aimed to optimize luliconazole nanoemulsion using Box–Behnken statistical layout, which have become further integrated into the polymeric gel of Carbopol 934. The system changed into characterized for its length, entrapment performance, ex vivo permeation, and mechanism of release. The duration of the dispersed globules of the optimized drug-loaded nanoemulsion become determined to be 17 ± 367 nm with a polydispersity index (PDI) a lot less than 0.05. Although the floor rate has become recorded at –9. Fifty 3 ± 0.251, the stability turned into maintained by way of the polymeric matrix that avoided aggregation and coalescence of the dispersed globules. The luliconazole-nanoemulgel (LUL-NEG) became characterized for drug content material analysis, viscosity, pH, and refractive index, wherein the consequences have been determined to be 99.06 ± 0. Fifty 9%, 9.26 ± 0.08 Pa.S, five. Sixty five ± 0.17, and 1.31 ± zero.08, respectively. The permeation in the course of the rat skin became decided to be extensively higher with LUL-NEG at the same time as compared with LUL gel. Furthermore, the pores and pores and skin contamination test carried out in experimental animals revealed that the smooth NEG, in addition to the LUL-NEG, did now not produce any signs of erythema following forty eighth publicity. In addition, the histopathological findings of the experimental skins stated no atypical signs at the gadget software program net page. Finally, the NEG components changed into placed to create a statistically huge region of inhibition (< 0.05) while compared to all special check businesses. Overall, it could be summarized that the nanoemulgel approach of handing over luliconazole during the skin to cope with pores and pores and skin fungal infections can be a promising method.
Assessment of Suspected Adverse Drug Reactions of Anti-Diabetic Drugs in a Tertiary Care Hospital of Eastern India
Authors: Kumar Dr Deepak , Raman Dr Ram Babu
Published: December 2022

Introduction: Patients with type 1 or type 2 diabetes mellitus need lifelong treatment with insulin or oral anti-diabetic drugs. So, they also have lifelong exposure to various adverse drug reactions (ADRs) associated with these agents. Due to discovery and utilisation of large number of drugs in last two decades, it has become more important to detect and report Adverse Drug Reactions (ADRs). Special attention and knowledge must be applied to identify suspected sign and symptoms in patients who are suffering from many comorbidities and receiving multiple medications. Aims/ objective: To highlight pattern of ADRs with use of oral anti-diabetic drugs and insulin therapy and to determine the risk factors and association of various drugs with common adverse effects to generate data for clinician for proper modification of pharmacotherapy of diabetes mellitus, thus minimizing incidence of ADRs. Materials and Method: Patients with any suspected adverse drug reactions (ADRs) to insulin or other anti-diabetic drugs were interviewed at their OPD visit. Information on the adverse event such as start or stop date & time of the ADR; dose, frequency, route and duration of suspected medications; action taken after the reaction; other concomitant medication; relevant laboratory investigation data and relevant past medical history were collected from the patient. Descriptive analysis was done to analyse and compare the results using percentages. Results: A total of 341 ADRs were reported from 207 patients. Nausea (30.50%) was most common reported ADR in our study followed by hypoglycaemia (17.30%) and weight gain (12.02%). Most of the cases of nausea, respiratory tract infection, abdominal pain, cough, joint pain and back pain were related to DPP-4 inhibitors. Hypoglycaemia and weight gain were mostly related to insulin followed by sulfonylurea. Most of the cases (56.89%) had probable causality relation to suspected drug. Conclusion: There is significant additional burden of ADRs on patients on type 2 diabetes mellitus who are already at more risk of various metabolic disorders. Proper counselling and measure to improve compliance can decrease the incidence of known adverse effects of anti-diabetic therapy.
Formulation and Development of Emulgel Infused with Calendula Oil for Treating the Exfoliative Cheilitis
Authors: Jodh Rahul , Jain Chetan , Behere Sudarshan , Randhave Nandini , Jirapure Prathamesh , Ingle Samruddhi
Published: December 2022

When gel and emulsion are mixed to make a dose, it is referred to as an Emulgel. Emulgel is one of the most exciting topical administration systems owing to its dual type of release control mechanism. The fundamental aim of this formulation is to transfer hydrophobic medication to the systemic circulation through the skin. Emulgel are essentially just water-based emulsions that have gone through a gelling process. The dermatological Emulgel is non-staining, water-soluble, emulsifying, thixotropic, simple to spread, easy to remove, thixotropic and environmentally friendly. Penetration enhancers may be used to increase the efficacy of a product. Consequently, it might be a more effective method of delivering topical medications than the current methods in use. It has become clear that Emulgel is an excellent delivery mechanism for hydrophobic compounds. Carbopol 934, a gelling chemical, was used in this study to create calendula oil Emulgel. Essential oils like clove and mentha were utilised to increase penetration. Afterward, the gel formulation was poured over the emulsion and allowed to harden. Rheological tests, spreading coefficient testing, and in vitro release investigations were conducted on Calendula oil topical Emulgel to determine their sun protection factor. Exfoliative cheilitis may be treated with calendula oil Emulgel applied to the skin.
Nanofibers: An Auspicious Drug Delivery Conveyor
Authors: B Sainavya. , Y Prasanth.
Published: December 2022

Because of their unique physiochemical qualities and attributes, nanofibers have produced an interesting one-dimensional nanomaterial for research and biomedical applications. Electrospun nanofibers are being used including therapeutics varying from antibiotics and oncology medicines to proteins, DNA, RNA, cell lines, and other bioactive molecules. Nanofibers special properties, such as high loading performance, superior mechanical effectiveness (rigidity and tensile strength), controlled release rate of the drug, and high stability will aid in the future delivery of plasmid DNA, protein drugs, genetic materials, and autologous stem cells to the specified location. The specific surface area to volume ratio of nanofibers is extreme. There are only a few approaches for making nanofibers accessible right now: The Electrospinning techniques includes electrospinning, self-assembly, phase separation, template synthesis, drawing, fibers mesh technology, and fiber bonding technology. Among these, the electro-spinning is excellently used technique. Several medications with low solubility can be integrated into the fibers to improve the bioavailability of the drug and provide controlled release using this technology. The Methodologies used to fabricate Nanofibers and their high-tech applications in medication delivery, tissue engineering, and wound dressing are described in detail in this review. It also makes recommendations for the future inquiry and hurdles in the domain.
The Role of Cardiac Magnetic Resonance in patients with Amyloidosis and Aortic Stenosis
Authors:   Hospital do Coração, Macedo Esmeraldo Barbosa Pedro , Magalhães Tiago Augusto ,   Hospital do Coração
Published: December 2022

Cardiac magnetic resonance imaging (CMR) plays an important role in the diagnosis and prognosis of various heart diseases. The incidence of cardiac amyloidosis and aortic stenosis has been increasing in recent years, especially with the aging population, and their possible coexistence has created frequent diagnostic challenges in clinical practice. CMR assumes an important value in this context due to its unique capacity for multiparametric assessment evaluations that include anatomical, functional, and histopathological aspects. The present review aimed to increase our knowledge of the diagnosis and prognosis of amyloidosis in the presence of aortic stenosis and highlighted the importance of CMR in this scenario.
STRATEGI PEMBELAJARAN PENDIDIKAN AGAMA ISLAM BERBASIS MULTIKULTURAL DI SMP NEGERI 1 SASAK RANAH PASISIE PASAMAN BARAT
Authors: Jaswir Jaswir , Dahlan Dasrizal , Rahmi Rahmi
Published: December 2022

This research was backgrounded by the diversity of students at SMP 1 Sasak Alam Pasisie, both from religions, tribes and languages. Plurality is a wealth in itself because with differences we will become more understanding that harmonious coexistence is a necessity, students must be accustomed to starting from the educational environment, namely school. For this reason, it is necessary to know the teacher's strategy in applying pai learning materials with a multicultural basis. The focus of his research is the implementation of Multicultural-Based PAI Learning at SMP 1 Sasak Alam Pasisie. The purpose of this study is to analyze and describe the evaluation of multicultural-based PAI learning at SMP 1 Sasak Alam Pasisie. This research uses observation techniques, documentation and interviews. For analysis techniques, use data reduction techniques, data display and drawing conclusions. The results of this study are that students at SMP 1 Sasak Alam Pasisie have shown satisfactory learning results judging from written test scores that reach KKM standards and in associating with friends of different religions and tribes have a very good tolerance attitude.
PANDANGAN ISLAM DAN PANDANGAN SUKU SAMAWA TERHADAP PERNIKAHAN SESAMA JENIS
Authors: Fahrurrozi Muhammad , Syahrani Nurfiya , Yakin Nurul
Published: December 2022

In recent years, the issue of same-sex marriage (gay and lesbian) is spreading on the surface and has been widely discussed by various groups. In Indonesia, the number of perpetrators of same-sex marriage is increasing in the name of human rights that must be respected and upheld, so this certainly raises pros and cons. This increase occurred due to increased internet access; the world of entertainment showing LGBT dramas; unrestricted access to pornography; narcotics; and the emergence of many LGBT movement organizations. In addition to biological factors, the influence of the immediate environment, namely family, relationships, and sexual violence, is also the cause of the emergence of LGBT. Same-sex marriage is prohibited in Islam because it violates nature and is contrary to Islamic Shari'a so that it triggers the maintenance of honor, soul, lineage, and reason. In short, same-sex marriage interferes with human physical and mental health. In the view of the Samawa tribe, same-sex marriage is also a deviant behavior, so that the perpetrator will be given punishment according to the existing customs and developed in the Samawa tribe.
ILMU PENGETAHUAN BERPARADIGMA UNITY OF SCIENCE
Authors: Afifa Erlina Laily Nur , Fitriana Anisa Syahla , Anggraini Nia , Nashikin Nashikin
Published: December 2022

Unity of science is the unification of human science, both in the ontological, epistemological, and axiological aspects of that knowledge, in one unified truth of essential knowledge, and monotheism as the main basis. As explained that science is knowledge collected by scientific methods, it is also explained that science is a systematic collection of knowledge that is built through experimentation and observation. In other words, science will only be realized if it is cultivated, built, and developed. Based on this explanation, this article aims to find out how to develop science based on Unity of Science. The method used in this study is a type of library research (library), in this study using library data as the object of study in the research, using books, articles as data sources. The results of the study concluded that Unity Of Science includes a matter that every existing science cannot stand alone. There is a connection between one science and another. Every science is multidimensional, where in writing and studying a branch of science requires the involvement and assistance of other auxiliary sciences. Research in this context is the basis for increasing scientific development. Research activity is an effort to formulate problems, ask these questions, by finding facts and providing correct interpretations.
Variability in Assessment of Preclinical Prosthodontics Work of Undergraduate Student
Authors: Elmaroush Mohamed
Published: December 2022

Background and objective. Clinical professions are often concerned not just on the knowledge acquisition, but achievement of skills and their application. Assessment tools employed in preclinical prosthodontic training vary widely, the two most common being used are the glance and grading method and the objective check list criteria, and any assessment procedure employed should be transparent in manner with both the staff and students informed of the purpose and the process adopted. This study was undertaken to examine whether introduction of an objective scoring criteria can improve the validity of scoring in assessment of preclinical prosthodontics (bite block) that done by students. Methods. The study evaluated 240 undergraduate students who were in second year of study at dental school Tripoli University, performing a bite block (trial denture base with wax rim) performed on ideal stone cast. The preclinical work (bite block) were evaluated and allotted marks by four blinded independent examiners using two methods of scoring, glance and grade method and objective checklist scoring method. Results. The data were parametric and met the normal distribution. Therefore, the scores were presented by mean and standard deviation. There was a significant difference (p value less than 0.005) between two scoring methods of preclinical prosthodontics work (glance and grade and objective checklist methods). Conclusion. This study concludes by recommending that preclinical prosthodontics work of students be assessed by objective checklist criteria scoring and it should be introduced after sufficient training and calibration sessions to induce examiner reliability.
Antimicrobial activity of jambu mawar [Syzygium jambos (L.) Alston] leaf extract against foodborne pathogens and spoilage microorganisms
Authors: Ali Salar Kadhum , Radu Son , Mahmud @ Ab Rashid Nor Khaizura , Rukayadi Yaya
Published: December 2022

The present work evaluated the antimicrobial potential of the ethanolic extract of jambu mawar [Syzygium jambos (L.) Alston] leaves against various foodborne pathogens and spoilage microorganisms via the disc diffusion assay (DDS) and the time-kill curve assay. These microorganisms included bacteria (Klebsiella pneumoniae ATCC13773, Listeria monocytogenes ATCC19112, Proteus mirabilis ATCC21100, Pseudomonas aeruginosa ATCC9027, Staphylococcus aureus ATCC29737, and Vibrio parahaemolyticus ATCC17802), yeasts (Candida albicans ATCC10231, C. krusei ATCC32196, C. glabrata ATCC2001, and C. parapsilosis ATCC22019), and moulds (Aspergillus fumigatus ATCC26430, A. niger ATCC9029, Rhizopus oligosporus ATCC22959, and R. oryzae ATCC22580). The inhibition zone of DDA ranged from 7.00 ± 0.23 to 10.25 ± 0.29 mm. The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal (MBC/MFC) of the ethanolic leaf extract were obtained at the concentrations of 0.01 to 2.50 and 0.01 to 5.00 mg/mL, respectively. The time-kill curve assay showed that except for P. mirabilis, other microorganisms were completely killed at MIC concentrations ranging from 0.5 to 4× MIC. In comparison, P. mirabilis showed a growth reduction of > 3 log10 CFU/mL for 4 h. Meanwhile, the conidial germination of A. fumigatus was fully inhibited at 0.5× MIC. Though not fully inhibited, the ethanolic leaf extract significantly reduced the conidial germination of A. niger, R. oryzae, and R. oligosporus to 7.0, 7.0, and 11.0%, respectively. Overall, the ethanolic leaf extract of S. jambos exhibited antimicrobial activity against foodborne pathogens and spoilage microorganisms.
Effects of soy protein hydrolysates on antioxidant activity and inhibition of muscle loss
Authors: Hou Yang , Yoon Youngkyun , Oh Eunyoung , Sung Bokyung , Kim Yookyung
Published: December 2022

Peptides show biological activity, and are more easily digested than complex proteins. In the present work, we evaluated the effects of soy hydrolysate on skeletal muscle. Soy protein isolate (SPI) was hydrolysed using 2% Alcalase (SPHA) and Flavourzyme (SPHF) at pH 8 for 3 h at 60°C, and at pH 7 for 3 h at 55°C, respectively. Antioxidant properties (total phenolic content and DPPH activity) and inhibition of muscle loss (myogenin, myosin heavy chain [MyHC], creatine kinase, and myostatin) by the SPI hydrolysates in C2C12 cells were compared with those of SPI. Alcalase produced more hydrolysed soy oligopeptides than Flavourzyme. Enzymatic hydrolysis increased the levels of essential amino acids, particularly in SPHF (2,466.85 mg/L) as compared to SPI (56.08 mg/L). The total phenolic contents of hydrolysates increased from 12.02 mg GAE/g in SPI to 22.87 and 18.67 mg GAE/g in SPHA and SPHF, respectively. The IC50 value of DPPH activity decreased four times after hydrolysis (SPI: 124.38, SPHA: 32.18, and SPHF: 30.21 mg/mL). SPHA and SPHF treatments increased the expression levels of both MyHC1 and MyHC3, as well as creatine kinase activity. A significant increase in MyHC3 expression was observed in SPHF at 10 µg/mL. Soy hydrolysates (SPHA: 93.5% and SPHF: 61%) induced a greater decrease in the expression of myostatin, a muscle reduction marker, than SPI (30.4%). In conclusion, soy hydrolysates may inhibit muscle loss, showing particularly better effects when Alcalase is used for hydrolysis.