bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Faktor yang Berhubungan dengan Kepercayaan Diri Akibat Timbulnya Acne Vulgaris pada Remaja Berdasarkan Teori Adaptasi Roy di SMA 17 Agustus 1945 Surabaya
Authors: Agustiningsih Tri , Pradanie Retnayu , Pratiwi Ika Nur
Published: July 2019

ABSTRACT Abstract: 85% adolescent in 15-18 years old suffers from acne vulgaris (Ayudianti & Indramaya 2014). Acne vulgaris can cause inflammation of the face, that can cause low self-confident’s problem too. The pupose of this study is to investigate correlation between physical aspect (phsycal appereance), social aspect (parent support), mental aspect (self perspective), and people knowledge about acne vulgaries. The purpose of this study is to investigate correlation with cross sectional approach. Data were collected using total sampling method and gain 156 respondents of first year and second year in SMA 17 Agustus 1945. Respondents were 156 people and recruited by total sampling method. The independent variable of this study is physical aspect (phsycal appereance), social aspect (parent support), mental aspect (self perspective), and people knowledge. The dependent variable of this study is  self-confidance. Data were collected using quissionaire and analyzed using spearman’s rho with significance level α<0,05. This study with significance level 0,000 showed correlation between physical aspect (physical appereansce) is 0,322, social aspect (parents support) is 0,778, mental aspect (self perspective) is 0,304, and knowledge is 0,377 towards self-confidance level in adolescent as result of acne vulgaris. There is significant correlation between physical aspect (phsycal appearance), social aspect (parents support), mental aspect (self perspective), and knowledge with self-esteem level as consequence of acne vulgaris. The next researcher is expected to give intervention in respondents of this study. It is also recommended at UKS nurses develop interventions suchKeywords : acne vulgaris, phsycal appereance, parents support, self perspective, knowledge, and self-confidance, adolescent.
En busca de una docencia transformada: ¿Cómo renovar culturas institucionales si no alteramos la formación de los docentes y sus prácticas?
Authors: Belén Godino Carmen María
Published: July 2019

Resumen:En el siguiente trabajo acercamos parte de la producción lograda a partir de la investigación que indagó en los procesos de transformación de la formación docente del nivel primario en el territorio nacional (Argentina) y provincial (San Luis). El interés se focalizó en conocer en profundidad cómo construyen la identidad docente las nuevas profesoras del nivel primario formadas en culturas institucionales renovadas. Se trabajó con dos técnicas de recolección de datos: el análisis documental (planes de estudio y documentos curriculares) y entrevistas en profundidad, a profesores de un Instituto de Formación Docente, a docentes egresadas y alumnas avanzadas de la carrera. Las principales conclusiones del estudio se relacionan con un claro posicionamiento por parte de la institución de educación superior: colaborar en la construcción de nuevas identidades docentes atribuyendo nuevos sentidos en relación a la complejidad de los contextos escolares. Los cambios introducidos en la formación docente desarrollada en las culturas institucionales actuales traducidos en la modificación de los planes de estudio y en el planteo de nuevas vinculaciones con las instituciones escolares, han provocado una continua revisión de los ejes que estructuran la formación docente, acción que posibilita visibilizar nuevos interrogantes sobre la micropolítica de las instituciones de formación docente.
Formación de profesores e identidad profesional: La contribución del trabajo colaborativo en educación
Authors: Ramos Gonçalves Daniela , Vieira da Silva María Cristina
Published: July 2019

Resumen:En el ámbito de la formación de profesores, presentamos la percepción de los estudiantes de los cursos de maestría de habilitación para la docencia sobre la contribución del trabajo colaborativo en el proceso de construcción de su identidad profesional. Los datos recogidos a partir de narrativas reflexivas sobre los que nos centramos reflejan las percepciones de 44 estudiantes a la salida de la primera experiencia de práctica de enseñanza supervisada que consideramos ilustrativa de un verdadero trabajo en red. El análisis de contenido de las narrativas se centra en cinco categorías de análisis: i) papel de los profesores supervisores de la IES en la realización de la PES; ii) el papel de los orientadores cooperantes en la realización de la PES; iii) adquisición / desarrollo de competencias relativas a la dimensión profesional, social y ética; iv) adquisición / desarrollo de competencias relativas a la dimensión de participación en la escuela y de relación con la comunidad; y v) adquisición / desarrollo de competencias reflexivas sobre la práctica. Entendemos que este es un proceso constructivo en el sentido en que el pasante se construye como profesional, mediante la forma como refleja, de forma autónoma, pero también a partir de la reflexión dialógica tanto con el par pedagógico / grupo del centro de práctica, como con el supervisor y orientador cooperante, en el contexto de la comunidad educativa en que actúa.
The problem of the settlement of the mountainous area of the Ukrainian Carpathians: contradictions of methodological approaches and interpretations
Authors: Dnistryanskyy Myroslav , Dnistryanska Natalia
Published: July 2019

The most controversial questions in research of settlement problems of the Ukrainian Carpathians are settling time, the role of different migratory movements and ethnic composition of immigrants. Historical records show that until the XIII century there was not an overall network of settlements in the mountainous areas of the Ukrainian Carpathians. Nevertheless, on the eve of that time, the Ukrainians quite rapidly adjusted directly to the foothills, Transcarpathian ways, they created defensive points in the highlands and carried out various nature use. Considering the socio-economic and security needs of the population of ancient foothill areas main migratory movement coming from the plains to mountain rivers flow to their origins, including the territory of Transcarpathia and Carpathian and Volyn and Podillya. The similarity place names on both sides of the Carpathians Ukrainian Transcarpathian confirm the influence of colonization movements that have left their traces in the mountains. Various historical and ethnographic artifacts indicate an important role in the settlement of the Carpathian mountain region south of colonization, i.e. relocation to the region population from the territory on the border of the middle and lower Danube, historic Transylvania and Moldova during the XIII-XVI centuries, which in the Commonwealth and some other states politically identified as “land Wlachs”. The main component of ethnic-social colonization was humanity southern Slavic-Rusyn origin. Settling mountain areas of Ukrainian Carpathians influenced the formation of the social structure of Ukrainian society, particularly on the spread of Ukrainian gentry, which was originally founding villages and their families. Value of different groups of immigrants from the south, north, west and east, as well as instituting the characteristics of the traditional economy and traditional culture under various environmental conditions and led to the formation of ethnic groups of the Ukrainian Carpathians (Boyko, Lemko, Hutsuls).
Key words: settlement of the Ukrainian Carpathians, South colonization, Ukrainian ethnographic groups, toponymy of the Ukrainian Carpathians, Transcarpathian relocation.
Doctor of geography Petro Oryshkevych (1909–1982): the way of life and scientific heritage
Authors: Stetsyuk Oksana
Published: July 2019

After the Second World War, many Ukrainian intellectuals were forced to leave their native land, but they still remained as true patriots of their land and had carried out Ukrainian research studies. The article is devoted to the activity of famous Ukrainian researcher who lived in the USA – Petro Oryshkevych (1909–1982) – a doctor of geography, a teacher, a public figure, director of the Taras Shevchenko School of Ukrainian Studies of Greater Washington, a correspondent member and secretary of the Branch of the Shevchenko Scientific Society in Washington. The main achievements of the scientist in publishing activities were illuminated.
The article describes Peter Oryshkevych as a teacher in many educational institutions of different countries: gymnasiums, seminary, trade and high schools in Peremyshl, Lviv, Zolochiv, Dillingen (Germany), Washington (USA). The contribution of Petro Oryshkevych in the creation (in 1957) and development of the Branch of the Scientific Society of Taras Shevchenko in Washington, where he was a Corresponding Member and Secretary of the Branch, is highlighted. The role of Petro Oryshkevych in the development of the Taras Shevchenko School of Ukrainian Studies of Greater Washington is described.
The description of the most important researcher’s works, which concern the learning of geography of Ukraine, and his scientific activity in emigration in the USA were given. In particular, the main works of the scientist were considered. Among them are Ukrainians of Zasyannya (1962), Introductory Geography of Ukraine and Ukrainian Settlements (1974), Geography of Ukrainians (Rusyny) of Great Washington (1981). Petro Oryshkevych had left a remarkable trace in Ukrainian geography. His scientific research is widely known both among Ukrainians abroad and in Ukraine.
Key words: Petro Oryshkevych, Ukrainian studies, Schools of Ukrainian studies, Shevchenko Scientific Society, schooling, Foreign Ukrainians, diaspora.
Kecenderungan melakukan bullying ditinjau dari jenis kelamin dan urutan kelahiran pada santri di Pondok Pesantren
Authors: Finiswati Endang , Matulessy Andik
Published: July 2019

Penelitian ini memiliki tujuan untuk mengetahui perbedaan kecenderungan melakukan bullying ditinjau dari jenis kelamin dan urutan kelahiran pada santri di pondok pesantren. Subyek penelitian ini adalah santriwan dan santriwati yang berdomisili di Pondok Pesantren Darul â€˜Ulum, Rejoso, Peterongan, Jombang. Subyek penelitian berjumlah 159 orang, dengan 82 santri laki-laki dan 77 santri perempuan atau dengan 92 santri anak pertama, 37 santri anak tengah dan 30 santri anak terakhir. Pengambilan data menggunakan skala likert kecenderungan melakukan bullying, kemudian dilakukan analisis Alpha Cronbach, Kolmogorov Smirnov dengan bantuan SPSS for Windows versi 20.0. Hasil analisis kecenderungan melakukan bullying pada santri ditinjau dari jenis kelamin menggunakan analisis Mann-Whitney menunjukkan bahwa nilai Z = -2,711 pada p = 0,007 (p < 0,05). Hal tersebut berarti ada perbedaan yang signifikan pada tingkat bullying antara laki-laki dan perempuan. Begitu juga hasil analisis kecenderungan melakukan bullying pada santri ditinjau dari urutan kelahiran menggunakan analisis Kruskal-Wallis Test menunjukkan nilai Chi-Square = 9,466 pada p = 0,009 (< 0,05), artinya terdapat perbedaan yang signifikan pada tingkat bullying antara anak pertama, anak tengah dan anak terakhir.Â Kata kunci : Bullying, Santri, Jenis Kelamin, Urutan Kelahiran
Socialization Model of Tacit-Tacit Transfer Knowledge through Appreciative Inquiry Approach
Authors: Rachmawati Ani Wahyu
Published: July 2019

The aims of study is to describe combination of two big theory between Socialization model of tacit-tacit transfer knowledge and appreciative inquiry approach conceptually. This research idea comes to find better ways in tacit-tacit transfer of knowledge in knowledge management theory. This research is conceptual research and the limitation is about empirical study itself. The result of conceptual paper combine the process of tacit-tacit tansfer knowledge and appreciate inquiry in mental model, creative dialogue and develop mutual trust. Appreciative inquiry as a method to increase positive sense in tranfer knowlegde can be applied in tacit-tacit transfer knowledge phase in SECI Model.
The Impact of Business Mentoring on Micro, Small, Medium Enterprises Performance
Authors: Adrian Mohammad , Mulyaningsih Hendrati Dwi , Rahmawati Santi
Published: July 2019

This reasearch is conducted on MMSME (Micro Small Medium Enterprises) that are participated in the MMSME Syari’ah Mentoring Program by Academicians and Practitioners (PUSPA) organized by Bank Indonesia in Bandung. MMSME who participated in PUSPA program 2016 is MMSME that included in necessity entrepreneur where MMSME operated just to fullfil the life necessities. The purpose of this reasearch was to investigate the influence of the business mentoring on the MMSME performance in PUSPA program 2016. Researcher used quantitative research method. Data were analyzed using simple regression analysis and descriptive-causal analysis. The result showed that business mentoring affect the performance of MMSME that participated in PUSPA Program 2016. Based on the calculation, coefficient of determination (R2) can be seen the influence of business mentoring variable (X) on the performance (Y) is 74%. While the remaining 26% is influenced by other factors such as entrepreneurship competence and human resources.
Modern Islam (Beginning of the 21st Cent.) A Reader (a review of a series of teaching manuals published by the Moscow State Institute of International Relations / MGIMO-University)
Authors: Arsenyev A. S.
Published: July 2019

Modern Islam (Beginning of the 21st Cent.) A Reader (a review of a series of teaching manuals published by the Moscow State Institute of International Relations / MGIMO-University).
Hypervigilance for bodily sensations in the back during a movement task in people with chronic and recurrent low back pain
Authors: Clauwaert Amanda , Schouppe Stijn , Van Oosterwijck Jessica , Danneels Lieven , Van Damme Stefaan
Published: July 2019

Objectives. The current study assessed the role of hypervigilance for bodily sensations in the back in long term low back pain (LBP) problems. Methods. People with chronic low back pain (CLBP), recurrent low back pain (RLBP), and no LBP were compared on the extent to which they attended to somatosensory stimuli on the back during a movement task. To measure hypervigilance, somatosensory event-related potentials (SEP) to task-irrelevant tactile stimuli on the back were measured when preparing movements in either a threatening or a neutral condition, indicated by a cue signaling possible pain on the back during movement or not. Results. Results showed stronger attending to stimuli on the back in the threat condition than in the neutral condition, as reflected by increased amplitude of the N96 SEP. However, this effect did not differ between groups. The CLBP group showed a larger P171 SEP than the other groups, but this effect was not dependent upon condition, suggesting a more general state of arousal resulting in increased somatosensory responsiveness. No significant associations were found between somatosensory attending to the back and theorized antecedents such as pain catastrophizing, pain-related fear and pain vigilance. Discussion. The current study confirmed that individuals preparing a movement attended more towards somatosensory stimuli at the lower back when anticipating back pain during the movement, as measured by the N96 SEP. However, no differences were found for this component between participants suffering from CLBP or RLBP, or the healthy controls.
Profesionalitas Seorang Guru Terhadap Motivasi Belajar Siswa
Authors: khoiriyah layyinatul
Published: July 2019

Motivasi dapat diartikan sebagai kekuatan seseorang yang dapat menimbulkan tingkat kemauan dalam melaksanakan suatu kegiatan. Kemauan baik yang bersumber dari dalam diri individu itu sendiri (motivasi intrinsik) maupun dari luar individu (motivasi ekstrinsik). Seberapa kuat motivasi yang dimiliki individu akan banyak menentukan kualitas perilaku yang ditampilkannya, baik dalam konteks belajar, bekerja maupun dalam kehidupan lainnya.
KORUPSI: dulu biasa sekarang luar biasa.
Authors: HETHARIA HENKY HERZON
Published: July 2019

Tulisan ini hendak menelusuri persoalan korupsi yang telah mewarnai sejarah panjang umat manusia, sejak zaman dulu hingga sekarang ini. Praktik korupsi yang di zaman dulu merupakan hal yang biasa dan terjadi di mana-mana pada hampir seluruh wilayah di dunia, khususnya pada kerajaan-kerajaan atau peradaban-peradaban besar di masa lampau, seperti di Babilonia, Israel, India, Cina, Yunani, Romawi, termasuk di Indonesia. Catatan-catatan sejarah memperlihatkan bahwa pada wilayah-wilayah ini, praktik korupsi telah menjadi hal yang wajar dan biasa, bahkan menjadi suatu kebiasaan karena berbagai sebab. Demikian pula di masa kini, korupsi masih menjadi persoalan sosial yang terjadi di hampir seluruh negara, tidak terkecuali di Indonesia. Namun, persoalan korupsi di masa kini telah menjadi persoalan yang luar biasa (extraordinary crime), di mana sebagian besar negara di dunia di bawah Perserikatan Bangsa-Bangsa menyatakan perang terhadap persoalan korupsi ini dan serius untuk memberantasnya. Persoalan korupsi bukan hanya masalah hukum (kejahatan) tetapi juga masalah etika (moral), karena itu, tulisan ini juga hendak memberikan pandangan teologis-etis terhadap masalah korupsi ini. Tulisan ini telah dipublikasi pada buku “Jelajah Sejarah Meraup Makna”, terbitan Maret 2019.
Large-amplitude Dithering Mitigates Glitches in Digital-to-analogue Converters
Authors: Eielsen Arnfinn , Leth John , Fleming Andrew J. , Wills Adrian , Ninness Brett
Published: July 2019

This paper develops and experimentally evaluates a dither-based method for improved generation of arbitrary signals in digital-to-analogue converters that exhibits glitches --- essentially converting the glitches from high-frequency to low-frequency disturbances. One major benefit of this behaviour appears in closed-loop control applications, as the glitch disturbance can be moved from outside control law bandwidth to inside control law bandwidth, enabling suppression by feedback. A behavioural model of glitches is presented and the effect of applying a dither signal is analysed in detail. Analytical and experimental results demonstrate that a dither signal with sufficiently large amplitude can mitigate the effect of glitches, when used in conjunction with a low-pass filter. Severe glitches appear in various digital-to-analogue converter topologies, including converter topologies that are used in high-precision motion control applications, such as adaptive optics and scanning force microscopy. Glitches introduce impulse-like disturbances which have a broadband frequency distribution. Low-pass filtering alone does not provide sufficient attenuation, and in applications with feedback control only frequency content within the control law bandwidth is attenuated. Hence, a high-frequency disturbance such as a glitch will not be suppressed. The use of dithering to suppress glitches is therefore beneficial in applications where errors in signal conversion are a primary concern, such as high-precision motion control or accurate reference signal generation.
konsep dasar,proses, dan ruang lingkup administrasi pendidikan
Authors: Yuliani Febi , Afriansyah Hade
Published: July 2019

This article aims to describe how the educational administration should be going on generally. The methodology used to arrange this article is Systematic Literature Review (SLR). First, researcher find relevant theories, and then make a conclusion about it, then analyzing, and finally make a new information based researcher analyzing. The result of this article base on the researcher analyzing is generally there are four steps to do educational administration. They are planning, actuating, controlling, and evaluating.
Administrasi Pendidik dan Tenaga Kependidikan
Authors: dewi septi putri , Afriansyah Hade
Published: July 2019

Administration of educators and education personnel is the overall process of the activities of educators to achieve educational goals effectively and efficiently. In this article the author uses the literature study method, by collecting material sourced from books, journals and others related to the administrative process of educators and education personnel. The purpose of this article is to fulfill structured assignments in the Administration and Supervision of Education courses. And it is knowledge especially for compilers and generally for readers, regarding the Administration of Educators and Education Personnel.
Ornamental Design and Incremental Innovation
Authors: Magliocca Gerard N.
Published: July 2019

86 Marquette Law Review 845 (2003)
Professionalizing Peer Review Suggestions for a More Ethical and Pedagogical Review Process
Authors: Sciullo Nick J. , Duncan Mike
Published: July 2019

Several major problems with peer review exist in the related humanities disciplines of rhetoric, communication, and composition studies: a preponderance of incompetent reviewers, a lack of constructive criticism and the maintenance of orthodoxy, relative ease in identifying blinded authors, editorial passivity, and long waits to receive reviews. We propose five solutions: training for reviewers and editors, reviewers signing their reviews, payment for reviewers, thirty-day review turnaround, and guidelines for reviewing promoted by collective action. Before such solutions could be implemented, however, the existing problems must be acknowledged.
A new legal science with an old aftertaste
Authors: Wilenmann Javier
Published: July 2019

Opposing a good old liberal self to the degraded image of a coercive present is a recurrent argumentative tool in criminal law scholarship. In an important new book, Markus Dubber attempts to make use of a more complex dualistic framework to better achieve the same objective – namely, subjecting penal power to a normative analysis of legitimacy. He argues that criminal law scholars on both sides of the Atlantic have failed to acknowledge the fact that penal power is constantly shaped by two concurring modes of thought: law and police. Thus, subjecting penal power to a reconstruction of the way in which they find their way into institutional reality would offer a path forward for a legal scholarship truly committed to a legal ideal of legitimacy. This review essay focuses on criticizing this diagnosis. It contends that the image of legitimacy analysis offered by the model neglects many of the most pressing issues faced by modern criminal justice. Thus, despite the convincing criticism to which some forms of scholarship are subjected, the book ends up producing an image of legitimacy analysis that is strikingly similar to its departure point.
Effects of cut-outs on the vibrational characteristics of a hollow shaft system
Authors: Saravanan Ganapathi , Venkatachalam Ramasamy , Nallakumarasamy Gurusamy
Published: July 2019

This study presents results concerning the vibrational characteristics of a mild steel and carbon/epoxy composite hollow shaft system under different boundary conditions. Finite element analysis has been deployed for critical investigation. The effect of cutout profile and its geometric location over natural frequency and mode shape is studied in detail. From the results, it is clear that the introduction and increase in the number of cutouts leads to a drastic reduction in the natural frequency of the system for both the cases. Moreover, the geometric location of cutouts has a predominant effect in deciding natural frequencies and corresponding mode shapes. The results presented in this study will yield higher levels of interest for engineers dealing with topology optimization problems, where material removal is inevitable.
THE MODEL OF FOLDING PROCESS AND BREACHES FORMATION IN BORISLAV-POKUTTIA ZONE OF THE PRECARPATHIAN DEFLECTION
Authors: Zhuchenko H.O. , Mykhailiv I.R. , Hoptariova N.V. , Horvanko H.D.
Published: July 2019

The topicality of the research is determined by the detailed study of the peculiarities of the geological structure of Boryslav-Pokuttia zone of the Precarpathian deflection, in particular of local structural forms as probable traps for oil and gas, for reliable prediction of the oil and gas potential of the subsoil. Boryslav-Pokuttia zone of the Precarpathian deflection refers to one of the oldest oil and gas producing regions in Ukraine. Its hydrocarbon potential is far from being exhausted. The complex block structure of Boryslav-Pokuttia zone requires the development of specific methods for conducting oil and gas prospecting. In this regard, determining the distribution nature of the local structures and specifying the peculiarities of their morphological forms in the area under investigation are of great importance. The issue of tracing tectonic disturbances and determining their screening ability which determines the possible existence of hydrocarbon deposits remains to be an urgent matter. Solving these issues will significantly improve the geological efficiency of prospecting and exploration in the areas of Boryslav-Pokuttia zone. At the modern stage of the Earth sciences development computer processing of geological data is widely used.Therefore, along with the traditional approach to describing structures as potential traps for oil and gas, it isnecessary to analyze their quantitative (numerical) parameters. It gives a possibility to confirm the stablished regularities more reasonably. Handling large array of quantitative indicators of local structures and the dependencies established among them makes it possible to simulate the processes that formed them and to determine the regularities of their distribution. The most important scientific and practical results include: the quantitative indicators ranking of the local structures of Boryslav-Pokuttia zone (the ranking contains four groups of structures classified according to their morphological texture); the investigated conditions for the formation of morphological varieties of local structures and the character of the distribution of tectonic deformations in them. The results of geological and mathematical simulation according to a complex of quantitative indicators help to state that local structures with certain morphological features, which are revealed to various extent in their deformations, are formed by tectonic movements of different magnitude and direction and are described by the numerical parameters peculiar only to them. Investigating the distribution of tectonic stresses and deformations, which can be estimated in quantitative indicators, will contribute to a more reliable prediction of the oil and gas potential of the subsoil. In its turn, it will improve significantly the geological performance of oil and gas prospecting in the areas of BoryslavPokuttia zone of the Precarpathian deflection.
Composição química e utilização de polpa cítrica na nutrição de não ruminantes: Revisão
Authors: Diaz-Vargas Mayra , Diaz Vargas Mayra , Duque Ramirez Carlos Felipe
Published: July 2019

The production of citrus fruits is a culture in the world, constituted by the industrialization of oranges, lemons, toranjas and tangerines, which represent approximately 98% of a whole industrialized culture; Citrus fruits are processed mainly to obtain juice, and also in the canning industry, this process produces the citrus pulp that represents approximately 45% of the total fruit. The citrus pulp is composed of husks, membranes and seeds. The citrus pulp byproduct can be used to minimize the production costs of the animals, reduce the environmental impact caused by the inappropriate disposal of these residues, the citrus pulp has a high nutritional value that characterizes it as an energy food and the properties improvement of intestinal health, the quality of the final product, oxidation and the parameters of productive performance.
Hemangioma conjuntival em cão: Relato de caso
Authors: Amancio Tatiane , Amancio Tatiane , Gonçalves da Silva Valente Lívia , Baesso Ghizzo Jonis , Souza Gonçalvez Tainá , Vieira Tonon Laura , Orbem Veronezi Luciane , Valente de Souza Guilherme
Published: July 2019

Ocular neoplasias can compromise eyesight and consequently the quality of life of the animals, are common conditions in the small animal clinic that require treatment and rapid diagnosis in order to achieve an efficient therapeutic response. Hemangioma is a benign vascular endothelial neoplasm with no peripheral invasion and may be associated with a high incidence of solar radiation. This paper reports the clinical case of a male Pit Bull dog, treated at the Unibave Veterinary Hospital (HVU), with a conjunctival nodule. The treatment was surgical dissection, with wide margins, with the aim of eliminating the entire tumor mass and guaranteeing a surgical margin free of tumor cells. The dissected sample was referred for histological evaluation and resulted in the diagnosis of hemangioma. The surgical treatment was successful, and the patient obtained clinical improvement, without complications in the trans and postoperative period.
High Antiurolithiatic Capacities of Isolated Fractions of the Hydromethanolic Extract fromPituranthos scopariusRoots
Authors: Benalia H. , Mahfoudi R. , Djeridane A. , Yousfi M.
Published: July 2019

Natural products, such as plant extracts, open a new horizon for the discovery of new antiurolithiatic agents. In AlgeriaPituranthos scopariuscommonly known as “guezzah”, one of the most important plants medicinal Saharan is used for the treatment and prevention of urinary lithiasis. The present study deals with the in vitro evaluation of the inhibitory effect on the formation of calcium oxalate kidney stones of isolated fractions fromPituranthos scopariusroots hydromethanolic extract. First, the study led to the isolation of four fractions (F1 = 107 mg, F2 = 19 mg, F3 = 7 mg, F4 = 18 mg) by combining two chromatographic techniques: open column chromatography and preparative thin layer chromatography (TLC). The in vitro antiurolithiatic activity of different isolated fractions has been carried out by two different models. In the turbidimetric assay, we have determined spectrophotometrically the effect of the isolated fractions (1g/l) on the oxalocalcic crystallization, induced by the addition of oxalate in urines from four subjects, whereas the gravimetric assay is used to measure the variation of uric acid and calcium urate renal calculi weight, after putting them in contact with 3 ml of the isolated fractions (1 g/l) during 30 days. In the two assays, the antiurolithiatic activity was compared with that of six antiurolithogenesis inhibitory standards: sodium citrate, succinimide pharbiol, foncitril, alcaphor, allopurinol, and phosphoneuros. The achieved results measured by the two tests show clearly that the fraction 1 (F1) has provided very important antiurolithiatic power (> 50% of inhibition) compared to the standard inhibitors. The in vitro obtained experimental results in this study show that thePituranthos scopariusroots are a biologically active natural source for the treatment of oxalocalcic lithiasis. Therefore, further experiments will be required to identify the molecules involved in the antiurolithiatic effect and to study their in vivo effects, which can be used therapeutically.
A Semi-Automatic Algorithm for Estimating Cobb Angle
Authors: Safari A , Parsaei H , Zamani A , Pourabbas B
Published: July 2019

Background: Scoliosis is the most common type of spinal deformity. A universal and standard method for evaluating scoliosis is Cobb angle measurement, but several studies have shown that there is intra- and inter- observer variation in measuring cobb angle manually.Objective: Develop a computer- assisted system to decrease operator-dependent errors in Cobb angle measurement.Methods: The spinal cord in the given x-ray image of the spine is highlighted using contract-stretching technique. The overall structural curvature of the spine is determined by a semi-automatic algorithm aided by the operator. Once the morphologic curve of the spine is determined, in the last step the cobb-angle is estimated by calculating the angle between two normal lines to the spinal curve at the inflection points of the curve.Results: Evaluation results of the developed algorithms using 14 radiographs of patients ( 4 - 40 years old) with cobb angle ranges from 34 - 82 degrees, revealed that the developed algorithm accurately estimated cobb angle. Statistical analysis showed that average angle values estimated using the developed method and that provided by experts are statistically equal. The correlation coefficient between the angle values estimated using the developed algorithm and those provided by the expert is 0.81.Conclusion: Compared with previous algorithms, the developed system is easy to use, less operator-dependent, accurate, and reliable. The obtained results are promising and show that the developed computer-based system could be used to quantify scoliosis by measuring Cobb angle.
Una nuova accezione del verbo עבר in Os 10,11bc
Authors: Zawadzki Arnold
Published: July 2019

The aim of the article is to present the possibility of adding a new meaning to the semantic field of the verb עבר in Hos 10:11bc. After having examined the three translation options of Hos 10:11bc (Marti/Rudolph, Jeremias, Harper/Kwakkel), the author analyses the syntax of the verse in order to propose his own solution. He shows that the antithetic structure of Hos 10,11bc is the key to understanding not only the sense of the verb עבר, used here, but also of the entire verse and its intricated theology.
Am Ende des Dritten Weges? Zur Entwicklung sozialdemokratischer Programmatik in Zeiten politischer und sozialer Polarisierung
Authors: Illan Luis
Published: July 2019

Die Neuausrichtung im Sinne eines Dritten Weges markierte zur Jahrtausendwende einen Paradigmenwechsel innerhalb der Programmatik sozialdemokratischer Parteien. Nach anfänglichen Wahlerfolgen wird nun jedoch gerade diese Hinwendung zur politischen Mitte als ein Grund für die Krise der Sozialdemokratie gesehen. Der Artikel untersucht am Beispiel der SPD, inwiefern fortschreitende Wahlniederlagen und eine zunehmende politische und gesellschaftliche Polarisierung zu einer Revision der normativen Grundlagen dieses Dritten Weges innerhalb der Sozialdemokratie führen.
Der Braunkohleausstieg
Authors: Bischoff Mirko
Published: July 2019

Es geht um den Braunkohleausstieg zugunsten des Klimas, um die Interessen der Industrie, um Arbeitsplätze. Dabei stehen sich zwei Lager gegenüber: auf der einen Seite die Industrie und die Kohlekumpel, die ihre Arbeitsplätze nicht verlieren wollen, und auf der anderen die Klimaschützer, die den Ausstieg aus der Braunkohle am liebsten sofort beginnen würden.
Digitaler Kapitalismus – wie immaterielle Werte unser Wirtschaftssystem verändern (könnten)
Authors: Petersen Thieß
Published: July 2019

Der Beitrag diskutiert zentrale Aussagen des viel beachteten Buchs „Capitalism without Capital“ und skizziert fünf mögliche wirtschaftliche Entwicklungen, die sich aus der voranschreitenden Digitalisierung und der wachsenden Bedeutung von immateriellen Werten ergeben könnten.
Interaction with Serum Albumin As a Factor of the Photodynamic Efficacy of Novel Bacteriopurpurinimide Derivatives
Authors: Аkimova А. V. , Rychkov G. N. , Grin М. А. , Filippova N. A. , Golovina G. V. , Durandin N. A. , Vinogradov A. M. , Коkrashvili Т. А. , Mironov А. F. , Shtil А. А. , Кuzmin V. А.
Published: July 2019

Optimization of the chemical structure of antitumor photosensitizers (PSs) is aimed at increasing their affinity to a transport protein, albumin and irreversible light-induced tumor cell damage. Bacteriopurpurinimide derivatives are promising PSs thanks to their ability to absorb light in the near infrared spectral region. Using spectrophotometry, we show that two new bacteriopurpurinimide derivatives with different substituents at the N atoms of the imide exocycle and the pyrrole ring A are capable of forming non-covalent complexes with human serum albumin (HSA). The association constant (calculated with the Benesi-Hildebrand equation) for N-ethoxybacteriopurpurinimide ethyloxime (compound 1) is higher than that for the methyl ether of methoxybacteriopurpurinimide (compound 2) (1.1810 5 M-1 vs. 1.2610 4 M -1, respectively). Molecular modeling provides details of the atomic interactions between 1 and 2 and amino acid residues in the FA1 binding site of HSA. The ethoxy group stabilizes the position of 1 within this site due to hydrophobic interaction with the protein. The higher affinity of 1 for HSA makes this compound more potent than 2 in photodynamic therapy for cultured human colon carcinoma cells. Photoactivation of 1 and 2 in cells induces rapid (within a few minutes of irradiation) necrosis. This mechanism of cell death may be efficient for eliminating tumors resistant to other therapies.
New Nanobiocomposite Materials for Bioelectronic Devices
Authors: Pankratov D. V. , González-Arribas E. , Parunova Yu. M. , Gorbacheva M. A. , Zeyfman Yu. S. , Kuznetsov S. V. , Lipkin A. V. , Shleev S. V.
Published: July 2019

We have developed and synthesized nanobiocomposite materials based on graphene, poly(3,4-ethylenedioxythiophene), and glucose oxidase immobilized on the surface of various nanomaterials (gold nanoparticles and multi-walled carbon nanotubes) of different sizes (carbon nanotubes of different diameters). Comparative studies of the possible influence of the nanomaterials nature on the bioelectrocatalytic characteristics of glucose-oxidizing bioanodes in a neutral phosphate buffer solution demonstrated that the bioelectrocatalytic current densities of nanocomposite-based bioanodes are only weakly dependent on the size of the nanomaterial and are primarily defined by its nature. The developed nanobiocomposites are promising materials for new bioelectronic devices due to the ease in adjusting their capacitive and bioelectrocatalytic characteristics, which allows one to use them for the production of dual-function electrodes: i.e., electrodes which are capable of generating and storing electric power simultaneously.
Thio Derivatives of 2(5H)-Furanone As Inhibitors against Bacillus subtilis Biofilms
Authors: Trizna E. Yu. , Khakimullina E. N. , Latypova L. Z. , Kurbangalieva A. R. , Sharafutdinov I. S. , Evtyugin V. G. , Babynin E. V. , Bogachev M. I. , Kayumov A. R.
Published: July 2019

Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections. While in the biofilm, bacteria exhibit increased resistance to antibiotics and the human immune system, causing difficulties in treatment. Thus, the development of biofilm formation inhibitors is a great challenge in pharmacology. The gram-positive bacterium Bacillus subtilis is widely used as a model organism for studying biofilm formation. Here, we report on the effect of new synthesized 2(5Н)-furanones on the biofilm formation by B.subtilis cells. Among 57 compounds tested, sulfur-containing derivatives of 2(5H)-furanone (F12, F15, and F94) repressed biofilm formation at a concentration of 10 g/ml. Derivatives F12 and F94 were found to inhibit the biosynthesis of GFP from the promoter of the eps operon encoding genes of the biofilm exopolysaccharide synthesis (EPS). Using the differential fluorescence staining of alive/dead cells, we demonstrated an increased bacterial sensitivity to antibiotics (kanamycin and chloramphenicol) in the presence of F12, F15, and F94, with F12 being the most efficient one. The derivative F15 was capable of disrupting an already formed biofilm and thereby increasing the efficiency of antibiotics.
The Use of Atomic Force Microscopy for 3D Analysis of Nucleic Acid Hybridization on Microarrays
Authors: Dubrovin E. V. , Presnova G. V. , Rubtsova M. Yu. , Egorov A. M. , Grigorenko V. G , Yaminsky I. V.
Published: July 2019

Oligonucleotide microarrays are considered today to be one of the most efficient methods of gene diagnostics. The capability of atomic force microscopy (AFM) to characterize the three-dimensional morphology of single molecules on a surface allows one to use it as an effective tool for the 3D analysis of a microarray for the detection of nucleic acids. The high resolution of AFM offers ways to decrease the detection threshold of target DNA and increase the signal-to-noise ratio. In this work, we suggest an approach to the evaluation of the results of hybridization of gold nanoparticle-labeled nucleic acids on silicon microarrays based on an AFM analysis of the surface both in air and in liquid which takes into account of their three-dimensional structure. We suggest a quantitative measure of the hybridization results which is based on the fraction of the surface area occupied by the nanoparticles.
Redistribution of Free- and Cell-Surface-Bound DNA in Blood of Benign and Malignant Prostate Tumor Patients
Authors: Bryzgunova O. E. , Tamkovich S. N. , Cherepanova A. V. , Yarmoshchuk S. V. , Permyakova V. I. , Anykeeva O. Yu. , Laktionov P. P.
Published: July 2019

A direct correlation between the concentration of cell-free and cell-surface-bound circulating DNA (cfDNA and csbDNA, respectively) was demonstrated. Based on an inverse correlation between blood plasma DNase activity and the cfDNA concentration, blood DNases are supposed to regulate the cfDNA concentration. However, no correlation was found between the DNase activity in blood plasma and the csbDNA concentration, indicating that blood DNases are not involved in csbDNA dissociation from the cell surface. The possibility of DNA redistribution between cfDNA and csbDNA indicates that the total pool of circulating DNA (cfDNA +csbDNA) should be used for a correct analysis of marker DNA concentrations and data standardization.
In Vitro Mouse Ovarian Follicle Growth and Maturation in Alginate Hydrogel: Current State of the Art
Authors: Filatov M. A. , Khramova Yu. V. , Semenova M. L.
Published: July 2019

This review describes the main factors affecting the in vitro development of mouse ovarian follicles under conditions of three-dimensional alginate hydrogel system. The factors discussed include concentration of alginate hydrogel, presence of additives (collagen, fibrin) influencing substrate rigidity; culture conditions; composition of culture media; substances that act like antioxidants (salts of ascorbic acid, glutathione) and contribute to the improvement of lipid metabolism (L-carnitine), hormones and growth factors. The methods for follicle group cultivation in alginate hydrogel and cocultivation of different cell populations with follicles encapsulated in alginate hydrogel are covered in the present article.
Modified Method of rRNA Structure Analysis Reveals Novel Characteristics of Box C/D RNA Analogues
Authors: Filippova Ju. A. , Stepanov G. A. , Semenov D. V , Koval O. A. , Kuligina E. V. , Rabinov I. V. , Richter V. A.
Published: July 2019

Ribosomal RNA (rRNA) maturation is a complex process that involves chemical modifications of the bases or sugar residues of specific nucleotides. One of the most abundant types of rRNA modifications, ribose 2-O-methylation, is guided by ribonucleoprotein complexes containing small nucleolar box C/D RNAs. Since the majority of 2-O-methylated nucleotides are located in the most conserved regions of rRNA that comprise functionally important centers of the ribosome, an alteration in a 2-O-methylation profile can affect ribosome assembly and function. One of the key approaches for localization of 2-O-methylated nucleotides in long RNAs is a method based on the termination of reverse transcription. The current study presents an adaptation of this method for the use of fluorescently labeled primers and analysis of termination products by capillary gel electrophoresis on an automated genetic analyzer. The developed approach allowed us to analyze the influence of the synthetic analogues of box C/D RNAs on post-transcriptional modifications of human 28S rRNA in MCF-7 cells. It has been established that the transfection of MCF-7 cells with a box C/D RNA analogue leads to an enhanced modification level of certain native sites of 2-O-methylation in the target rRNA. The observed effect of synthetic RNAs on the 2-O-methylation of rRNA in human cells demonstrates a path towards targeted regulation of rRNA post-transcriptional maturation. The described approach can be applied in the development of novel diagnostic methods for detecting diseases in humans.
5-Arylaminouracil Derivatives as Potential Dual-Action Agents
Authors: Matyugina E. S. , Novikov M. S. , Babkov D. A. , Valuev-Elliston V. T. , Vanpouille C. , Zicari S. , Corona A. , Tramontano E. , Margolis L. B. , Khandazhinskaya A. L. , Kochetkov S. N.
Published: July 2019

Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 g/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (МT-4 cells) and ex vivo (human tonsillar tissue).
浅论初中立定跳远教学方法及其策略
Authors: 邹 启莲
Published: July 2019

立定跳远是初中体育教学中的一项重要内容。其主要是指不用助跑,从立定姿势开始,双手配合身体前后摆动,脚趾、脚跟可以交替离地,用上摆蹲、跳收、伸着等多种技术的一项跳远运动。为了提高初中立定跳远教学效果,本文阐述了立定跳远技术,对初中立定跳远教学方法及其策略进行了论述分析。
小学语文教学新课改下提升学生表达能力的探究
Authors: 唐 梅
Published: July 2019

新课程改革后,我国小学教育逐渐将教学重点转移到对学生能力的培养上,通过全方位发展学生能力,提高学生的综合素质,为学生的未来发展奠定坚实基础。而在小学语文教学中,对学生表达能力的培养始终是教学工作的重点,表达能力是发挥语文工具性作用的主要渠道。基于此,文章对小学语文教学新课改下提升学生表达能力展开了具体探究,以便为小学语文教师提供参考与借鉴,促进其快速转变教学理念,为学生提供更优质的教学服务。
体育游戏在大学体育教学中的应用
Authors: 张 玉玺
Published: July 2019

随着高校体育教学改革的不断推进,传统以体育理论知识为主的教学模式显然难以满足当前的高校教育需求。所以在高校体育教学过程中,不仅需要教师教授学生丰富的体育理论知识,并且还得重视学生体育技能的培养,同时还应该积极的提升体育教学的趣味性,以此来为学生营造一种轻松愉悦的体育学习氛围。而在大学体育教学中合理的应用体育教学则时能够很好的达到这一点。本文主要针对体育游戏在大学体育教学中的实践应用进行了详细的分析。
浅谈语境在高中英语词汇教学中的运用
Authors: 孟 江梅
Published: July 2019

在高中英语教学中,英语词汇教学是其中的重点内容和基础内容。在词汇应用不恰当时,学生将无法理解英语语句,难以开展英语写作创作等。因此,高中英语教师为了有效地提升英语教学的整体质量,需要积极开展高中英语词汇教学,以实现预期的教学效果。基于此,文章研究了语境在高中英语词汇教学中的运用。
校企合作背景下的上海轨道交通企业高技能人才培养模式的探索
Authors: 张 国庆
Published: July 2019

高技能人才是我国人才队伍的重要组成部分,是推动技术创新和实现科技成果转化的重要力量。加快高技能人才队伍建设,关系到我国核心竞争力和综合国力的增强,是贯彻落实科学发展观,实施人才强国战略,建设创新型国家的重要举措。
Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
Authors: Carbone Michele , Adusumilli Prasad S. , Alexander H. Richard , Baas Paul , Bardelli Fabrizio , Bononi Angela , Bueno Raphael , Felley‐Bosco Emanuela , Galateau‐Salle Francoise , Jablons David , Mansfield Aaron S. , Minaai Michael , de Perrot Marc , Pesavento Patricia , Rusch Valerie , Severson David T. , Taioli Emanuela , Tsao Anne , Woodard Gavitt , Yang Haining , Zauderer Marjorie G. , Pass Harvey I.
Published: July 2019

Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts of asbestos. The incidence rate of mesothelioma has decreased in Australia, the United States, and Western Europe, where the use of asbestos was banned or strictly regulated in the 1970s and 1980s, demonstrating the value of these preventive measures. However, in these same countries, the overall number of deaths from mesothelioma has not decreased as the size of the population and the percentage of old people have increased. Moreover, hotspots of mesothelioma may occur when carcinogenic fibers that are present in the environment are disturbed as rural areas are being developed. Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high‐resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies. The discovery that germline BRCA1‐asssociated protein 1 (BAP1) mutations cause mesothelioma and other cancers (BAP1 cancer syndrome) elucidated some of the key pathogenic mechanisms, and treatments targeting these molecular mechanisms and/or modulating the immune response are being tested. The role of surgery in pleural mesothelioma is controversial as it is difficult to predict who will benefit from aggressive management, even when local therapies are added to existing or novel systemic treatments. Treatment outcomes are improving, however, for peritoneal mesothelioma. Multidisciplinary international collaboration will be necessary to improve prevention, early detection, and treatment.