bluuebunny/crossref_metadata_2025 huggingface dataset:
Advanced Xenograft Model with Cotransplantation of Patient-Derived Organoids and Endothelial Colony-Forming Cells for Precision Medicine
Authors: Kwon Junhye , Oh Sungryong , Park Misun , Kong Joon Seog , Lee Sunyi , Lee Hyunsook , Kim Younjoo , Kang Kyu-Tae , Shin Ui Sup , Jung Joohee
Published: July 2021

Preclinical evaluation models have been developed for precision medicine, with patient-derived xenograft models (PDXs) and patient-derived organoids (PDOs) attracting increasing attention. However, each of these models has application limitations. In this study, an advanced xenograft model was established and used for drug screening. PDO and endothelial colony-forming cells (ECFCs) were cotransplanted in NRGA mice (PDOXwE) to prepare the model, which could also be subcultured in Balb/c nude mice. Our DNA sequencing analysis and immunohistochemistry results indicated that PDOXwE maintained patient genetic information and tumor heterogeneity. Moreover, the model enhanced tumor growth more than the PDO-bearing xenograft model (PDOX). The PDO, PDOXwE, and clinical data were also compared in the liver metastasis of a colorectal cancer patient, demonstrating that the chemosensitivity of PDO and PDOXwE coincided with the clinical data. These results suggest that PDOXwE is an improvement of PDOX and is suitable as an evaluation model for precision medicine.
Research on Bidding Game and Its Application Based on Copetition Scenario
Authors: Sun Yanyong
Published: July 2021

Bidding decision is not only a science, an art, but also a game. The more intense the competition, the more important the game. In practice, there is the possibility of collaboration between bidders and even hidden competing behaviors such as bidding rigging. In this study, the optimized low-price bid winning method was discussed, and the characteristics and application of the bidding game under the copetition scenarios were studied. The results show the following: (1) Under the copetition scenario, the rational bidding behavior of bidders will deviate according to the different information advantages, and there is a game of making bidding strategy decisions according to the competitive scenario. (2) There is a close functional relationship between the winning bid result and the evaluation elimination factor, the number of bidders, and the number of bidders who operate bidding rigging. (3) Based on the quotation strategy matrix modeling, it enables the quantitative decision making bid amount, offer score, and deviation risk. This study enriches the theory of quota decision in copetition scenarios and is enlightening for similar business behavior game decisions.
Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities
Authors: Chua Khi Pin , Teng Yvonne H.F. , Tan Aaron C. , Takano Angela , Alvarez Jacob J.S. , Nahar Rahul , Rohatgi Neha , Lai Gillianne G.Y. , Aung Zaw Win , Yeong Joe P.S. , Lim Kiat Hon , Naeini Marjan Mojtabavi , Kassam Irfahan , Jain Amit , Tan Wan Ling , Gogna Apoorva , Too Chow Wei , Kanesvaran Ravindran , Ng Quan Sing , Ang Mei Kim , Rajasekaran Tanujaa , Anantham Devanand , Phua Ghee Chee , Tan Bien Soo , Lee Yin Yeng , Wang Lanying , Teo Audrey S.M. , Khng Alexis Jiaying , Lim Ming Jie , Suteja Lisda , Toh Chee Keong , Lim Wan-Teck , Iyer N. Gopalakrishna , Tam Wai Leong , Tan Eng-Huat , Zhai Weiwei , Hillmer Axel M. , Skanderup Anders J. , Tan Daniel S.W.
Published: July 2021

Purpose:

Despite the established role of EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutated NSCLC, drug resistance inevitably ensues, with a paucity of treatment options especially in EGFRT790M-negative resistance.

Experimental Design:

We performed whole-exome and transcriptome analysis of 59 patients with first- and second-generation EGFR TKI-resistant metastatic EGFR-mutated NSCLC to characterize and compare molecular alterations mediating resistance in T790M-positive (T790M+) and -negative (T790M−) disease.

Results:

Transcriptomic analysis revealed ubiquitous loss of adenocarcinoma lineage gene expression in T790M− tumors, orthogonally validated using multiplex IHC. There was enrichment of genomic features such as TP53 alterations, 3q chromosomal amplifications, whole-genome doubling and nonaging mutational signatures in T790M− tumors. Almost half of resistant tumors were further classified as immunehot, with clinical outcomes conditional on immune cell-infiltration state and T790M status. Finally, using a Bayesian statistical approach, we explored how T790M− and T790M+ disease might be predicted using comprehensive genomic and transcriptomic profiles of treatment-naïve patients.

Conclusions:

Our results illustrate the interplay between genetic alterations, cell lineage plasticity, and immune microenvironment in shaping divergent TKI resistance and outcome trajectories in EGFR-mutated NSCLC. Genomic and transcriptomic profiling may facilitate the design of bespoke therapeutic approaches tailored to a tumor's adaptive potential.
MRN Complex and Cancer Risk: Old Bottles, New Wine
Authors: Elkholi Islam E. , Foulkes William D. , Rivera Barbara
Published: July 2021

The MRN complex, composed of MRE11A, RAD50, and NBN, mediates vital molecular functions to maintain genomic stability and hence protect against related disorders. Germline mutations in the MRN genes predispose to three different syndromes: ataxia-telangiectasia-like disorder (MRE11A deficiency), Nijmegen breakage syndrome (NBS; NBN deficiency), and NBS-like disorder (RAD50 deficiency). The potential cancer component of these syndromes in addition to the close physical and functional proximity of the MRN complex to BRCA1 has promoted the MRN genes as candidate risk genes for developing breast cancer. This notion has been challenged by independent large-scale population-based studies. Despite having their two-decade old candidacy as breast cancer genes close to being refuted, it has recently been reported that the MRN genes rise to have potential new roles in clonal hematopoiesis. In this article, we discuss the history and current status of MRN genes' clinical utility in breast cancer and then focus on their recently uncovered and less understood roles in clonal hematopoiesis that likely predispose to health-related disorders such as hematologic malignancies and/or cardiovascular morbid events.
Efficacy, Safety, and Biomarker Analysis of Combined PD-L1 (Atezolizumab) and VEGF (Bevacizumab) Blockade in Advanced Malignant Peritoneal Mesothelioma
Authors: Raghav Kanwal , Liu Suyu , Overman Michael J. , Willett Anneleis F. , Knafl Mark , Fu Szu-Chin , Malpica Anais , Prasad Seema , Royal Richard E. , Scally Christopher P. , Mansfield Paul F. , Wistuba Ignacio I. , Futreal Andrew P. , Maru Dipen M. , Solis Soto Luisa M. , Parra Cuentas Edwin R. , Chen Honglei , Villalobos Pamela , Verma Anuj , Mahvash Armeen , Hwu Patrick , Cortazar Patricia , McKenna Edward , Yun Cindy , Dervin Shannon , Schulze Katja , Darbonne Walter C. , Morani Ajaykumar C. , Kopetz Scott , Fournier Keith F. , Woodman Scott E. , Yao James C. , Varadhachary Gauri R. , Halperin Daniel M.
Published: July 2021

Malignant peritoneal mesothelioma (MPeM) is a rare but aggressive malignancy with limited treatment options. VEGF inhibition enhances efficacy of immune-checkpoint inhibitors by reworking the immunosuppressive tumor milieu. Efficacy and safety of combined PD-L1 (atezolizumab) and VEGF (bevacizumab) blockade (AtezoBev) was assessed in 20 patients with advanced and unresectable MPeM with progression or intolerance to prior platinum–pemetrexed chemotherapy. The primary endpoint of confirmed objective response rate per RECISTv1.1 by independent radiology review was 40% [8/20; 95% confidence interval (CI), 19.1–64.0] with median response duration of 12.8 months. Six (75%) responses lasted for >10 months. Progression-free and overall survival at one year were 61% (95% CI, 35–80) and 85% (95% CI, 60–95), respectively. Responses occurred notwithstanding low tumor mutation burden and PD-L1 expression status. Baseline epithelial–mesenchymal transition gene expression correlated with therapeutic resistance/response (r = 0.80; P = 0.0010). AtezoBev showed promising and durable efficacy in patients with advanced MPeM with an acceptable safety profile, and these results address a grave unmet need for this orphan disease.

Significance:

Efficacy of atezolizumab and bevacizumab vis-à-vis response rates and survival in advanced peritoneal mesothelioma previously treated with chemotherapy surpassed outcomes expected with conventional therapies. Biomarker analyses uncovered epithelial–mesenchymal transition phenotype as an important resistance mechanism and showcase the value and feasibility of performing translationally driven clinical trials in rare tumors.

See related commentary by Aldea et al., p. 2674.

This article is highlighted in the In This Issue feature, p. 2659
Balloon-Occluded Transarterial Chemoembolization: In Which Size Range Does It Perform Best? A Comparison of Its Efficacy versus Conventional Transarterial Chemoembolization, Using Propensity Score Matching
Authors: Golfieri Rita , Bezzi Mario , Verset Gontran , Fucilli Fabio , Mosconi Cristina , Cappelli Alberta , Paccapelo Alexandro , Lucatelli Pierleone , Magand Nicolas , Rode Agnes , De Baere Thierry
Published: July 2021

Introduction: The aim of this multicenter comparison of balloon-occluded transarterial chemoembolization (B-TACE) versus conventional TACE (cTACE) in treating hepatocellular carcinoma (HCC) was to assess in which size range the 2 techniques offered higher complete response (CR) and objective response (OR) rates in a single session, and to evaluate the possibility of using B-TACE to reduce the need for re-treatment. Methods: 325 patients were retrospectively evaluated: 91 patients in the B-TACE group (22 with cTACE [B-cTACE] and 69 with drug-eluting microsphere TACE [B-DEM-TACE]) and 234 in the cTACE group. The results were compared according to tumor size: (A) <30 mm, (B) 30–50 mm, and (C) >50 mm; OR and CR rates after the first session and the number of TACE re-interventions within a 6-month period were also evaluated using propensity score matching (PSM). Results: The best target ORs were very high (93.2%) and similar between the 2 treatments both before (94.4% for cTACE and 90.1% for B-TACE) and after PSM (94.5% for cTACE and 90.1%; p = 0.405), with slightly better results for the cTACE cohort probably due to better cTACE effectiveness in smaller lesions. In lesions <30 mm, cTACE obtained a slightly higher CR rate than B-TACE (61.9 vs. 56.3%, p = 0.680), whereas in intermediate-sized HCCs (30–50 mm), B-TACE showed a significant superiority in achieving a CR (72.3 vs. 54.1%, respectively; p = 0.047). In larger lesions (>50 mm), cTACE and B-TACE performed equally, with a poor CR rate (22.6 vs. 23.1%, respectively; p = 1.000). These results were additionally confirmed using PSM. The patients treated with B-TACE had a significantly lower re-treatment rate than the cTACE cohort (12.1 vs. 26.9%, respectively; p = 0.005). B-cTACE and B-DEM-TACE demonstrated similar ORs, with a slightly better CR rate for B-cTACE (68.2 vs. 56.5%, respectively; p = 0.456). Conclusion: In HCCs of 30–50 mm, B-TACE should be preferred to cTACE, whereas in smaller nodules (<30 mm), cTACE can suffice in achieving a good CR rate. The statistically significant lower re-treatment rate of the B-TACE cohort after a single procedure reduced the risk of complications due to multiple TACE, which could worsen the patient prognosis.
Use of Point-of-Care Ultrasound for Evaluation of Extravascular and Intravascular Fluid Status in Pediatric Patients Maintained on Chronic Hemodialysis
Authors: Haskin Orly , Falush Yafa , Davidovits Miriam , Alfandary Hadas , Levi Shelly , Berant Ron
Published: July 2021

Aims: Traditional methods that use clinical parameters to determine dry weight in hemodialysis patients are inaccurate. This study aimed to compare clinical assessment of fluid status to sonographic parameters of fluid status in pediatric patients undergoing chronic hemodialysis. Methods: In a prospective observational study, pediatric patients maintained on chronic hemodialysis (ages 2.3–20 years) were evaluated clinically and sonographically before and after dialysis at 6 consecutive sessions. Sonographic parameters examined were number of lung B-lines as a measure of extravascular volume and inferior vena cava (IVC)/aorta ratio as a measure of intravascular volume. Clinical assessment of fluid status was compared to sonographic assessment. Results: Twelve patients were evaluated during 72 dialysis sessions. Sonographic parameters were significantly lower post-dialysis than pre-dialysis (B-lines number 4.5 ± 5 vs. 7.69 ± 7.46, p < 0.0001; IVC/aorta ratio 0.9 ± 0.2 vs. 1.1 ± 0.2, p < 0.0001, respectively). Ultrafiltration volume correlated with change in B-lines number during dialysis (r = 0.39, p < 0.01). Percent of blood volume drop correlated with post-dialysis IVC/aorta ratio (r = 0.48, p < 0.001). A higher percent of symptomatic episodes occurred with post-dialysis IVC/aorta ratio <0.8 versus ≥0.8 (39.1 vs. 15.2%, p = 0.036). Four patients were hypertensive, a clinical parameter implying fluid overload, in only one sonographic evaluation indicated fluid overload. Eight patients were clinically determined to be euvolemic, in three of them sonographic evaluation discovered covert fluids. Conclusion: Bedside ultrasound is a single modality that can be used to assess both extravascular and intravascular fluid status. It may contribute to clinical decisions differentiating fluid-related versus fluid-unrelated hypertension and identifying patients with covert fluids.
Tools and Signs in Massive Open Online Courses: Implications for Learning and Design
Authors: Engeness Irina
Published: July 2021

Understanding learning as a psychological process has been downplayed in the design of massive open online courses (MOOCs). This study draws on the cultural-historical perspectives of Vygotsky and Galperin to offer the design principles for MOOCs to enhance the learning and development of learners. The study argues that the suggested design principles emphasize the interplay between digital tools and the design of MOOCs to facilitate learners’ move from interacting with digital tools to developing their conceptual grasp and understanding of how to engage in online learning. During this process, digital tools acquire psychological significance to become signs, while the digital environment (MOOC) becomes a tool for studying the essence of online learning and positions learners as conscious agents who possess the capacity to learn.
Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin‐Mediated Sympathetic Activation and Inflammation in Diet‐Induced Obese Rats
Authors: Liu Xuefei , Zheng Hong
Published: July 2021

Background

Hypothalamic leptin‐mediated signaling contributes to the exaggerated sympatho‐excitation and increased blood pressure in obesity‐associated hypertension. The aim of the study was to investigate the roles of energy‐sensing enzyme sirtuin1 (Sirt1) and forkhead box protein O1 (FoxO1) on the hypothalamic leptin‐mediated high sympathetic nerve activity and inflammation in obesity.

Methods and Results

Sprague Dawley rats were fed with high‐fat diet (HFD) for 12 weeks. In vivo, the potential of Srit1 and FoxO1 in the sympathetic effects of leptin was investigated via siRNA injection to knockdown Sirt1 or FoxO1 gene in the arcuate nucleus (ARCN) of hypothalamus in rats. In vitro, the effects of Sirt1 or FoxO1 on leptin‐mediated inflammation were observed in proopiomelanocortin (POMC) and microglial cells. Knockdown Sirt1 by siRNA significantly reduced the renal sympathetic nerve activity (RSNA) and blood pressure responses to leptin injection in the ARCN in the HFD rats. Conversely, knockdown FoxO1 significantly enhanced the RSNA and blood pressure responses to leptin injection in the HFD rats. Knockdown Sirt1 reduced the levels of pro‐inflammatory cytokines interleukin 6 (IL‐6), tumor necrosis factor α (TNF‐α), interleukin 1β (IL‐1β), C1q/TNF‐related protein‐1 (CTRP1), and immune cell infiltration in the ARCN in the HFD rats. Knockdown FoxO1 significantly increased the level of IL‐6 in the ARCN of HFD rats. In cultured hypothalamic POMC and microglial cells, knockdown Sirt1 significantly reduced leptin‐induced IL‐6 expression, affected the levels of AMP‐activated protein kinase (AMPK) and serine/threonine‐specific protein kinase (Akt). Knockdown FoxO1 significantly increased leptin‐induced IL‐6 in both POMC cells and microglial cells.

Conclusions

These data suggest that both Sirt1 and FoxO1 are the key modulators of leptin signaling in the hypothalamus contributed to the over sympathetic activation and inflammation in obesity.
Predictors of Permanent Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement ‐ A Systematic Review and Meta‐Analysis
Authors: Ullah Waqas , Zahid Salman , Zaidi Syeda Ramsha , Sarvepalli Deepika , Haq Shujaul , Roomi Sohaib , Mukhtar Maryam , Khan Muhammad Atif , Gowda Smitha Narayana , Ruggiero Nicholas , Vishnevsky Alec , Fischman David L.
Published: July 2021

Background

As transcatheter aortic valve replacement (TAVR) technology expands to healthy and lower‐risk populations, the burden and predictors of procedure‐related complications including the need for permanent pacemaker (PPM) implantation needs to be identified.

Methods and Results

Digital databases were systematically searched to identify studies reporting the incidence of PPM implantation after TAVR. A random‐ and fixed‐effects model was used to calculate unadjusted odds ratios (OR) for all predictors. A total of 78 studies, recruiting 31 261 patients were included in the final analysis. Overall, 6212 patients required a PPM, with a mean of 18.9% PPM per study and net rate ranging from 0.16% to 51%. The pooled estimates on a random‐effects model indicated significantly higher odds of post‐TAVR PPM implantation for men (OR, 1.16; 95% CI, 1.04–1.28); for patients with baseline mobitz type‐1 second‐degree atrioventricular block (OR, 3.13; 95% CI, 1.64–5.93), left anterior hemiblock (OR, 1.43; 95% CI, 1.09–1.86), bifascicular block (OR, 2.59; 95% CI, 1.52–4.42), right bundle‐branch block (OR, 2.48; 95% CI, 2.17–2.83), and for periprocedural atriorventricular block (OR, 4.17; 95% CI, 2.69–6.46). The mechanically expandable valves had 1.44 (95% CI, 1.18–1.76), while self‐expandable valves had 1.93 (95% CI, 1.42–2.63) fold higher odds of PPM requirement compared with self‐expandable and balloon‐expandable valves, respectively.

Conclusions

Male sex, baseline atrioventricular conduction delays, intraprocedural atrioventricular block, and use of mechanically expandable and self‐expanding prosthesis served as positive predictors of PPM implantation in patients undergoing TAVR.
Risk of Physical Injury for Dispatched Citizen Responders to Out‐of‐Hospital Cardiac Arrest
Authors: Andelius Linn , Malta Hansen Carolina , Tofte Gregers Mads C. , Kragh Astrid M. Rolin , Køber Lars , Gislason Gunnar H. , Kjær Ersbøll Annette , Torp‐Pedersen Christian , Folke Fredrik
Published: July 2021

Background

Citizen responder programs are implemented worldwide to dispatch volunteer citizens to participate in out‐of‐hospital cardiac arrest resuscitation. However, the risk of injuries in relation to activation is largely unknown. We aimed to assess the risk of physical injury for dispatched citizen responders.

Methods and Results

Since September 2017, citizen responders have been activated through a smartphone application when located close to a suspected cardiac arrest in the Capital Region of Denmark. A survey was sent to all activated citizen responders, including a specific question about risk of acquiring an injury during activation. We included all surveys from September 1, 2017, to May 15, 2020. From May 15, 2019, to May 15, 2020, we followed up on all survey nonresponders by phone call, e‐mail, or text messages to examine if nonresponders were at higher risk of severe or fatal injuries. In 1665 suspected out‐of‐hospital cardiac arrests, 9574 citizen responders were dispatched and 76.6% (7334) answered the question regarding physical injury. No injury was reported by 99.3% (7281) of the responders. Being at risk of physical injury was reported by 0.3% (24), whereas 0.4% (26) reported an injury (25 minor injuries and 1 severe injury [ankle fracture]). When following up on nonresponders (2472), we reached 99.1% (2449). No one reported acquired injuries, and only 1 reported being at risk of injury.

Conclusions

We found low risk of physical injury reported by volunteer citizen responders dispatched to out‐of‐hospital cardiac arrest. Risk of injury should be considered and monitored as a safety measure in citizen responder programs.
PANDEMİ DÖNEMİNDE KOD 29 İLE İŞTEN ATILMAK
Authors: BAYRAKCI Onur
Published: July 2021

Bu çalışmada pandemi ile birlikte istihdam alanında yaşanan gelişmeler kod 29 olarak bilinen kanun maddesiyle ile ele alınmıştır. Kod 29 “İşveren tarafından ahlak ve iyi niyet kurallarına aykırı davranış nedeni ile iş akdinin feshi" olarak tanımlanmaktadır. Bu kanun aracılığıyla işverenler pandemide hükümetin yasak kararına rağmen işçi çıkarımına keyfi olarak devam etmektedirler. Çalışmanın önemi akademik olarak doğrudan kod 29 ile ilgili ilk çalışma olmasından kaynaklanmaktadır. Çalışmada yöntem olarak literatür çalışması yapılmış, internet kaynaklarına başvuru yapılmıştır. Bu yönteme başvurmanın nedeni ise bahsedildiği gibi doğrudan kod 29’u ilgilendiren çalışmaların yokluğudur. Çalışma da elde edilen bulgular ise kod 29’un yanlış kullanıldığı ve çalışanlar üzerinde onarılmaz mağduriyet yarattığıdır.
The Two-Margin Problem in Insurance Markets
Authors: Geruso Michael , Layton Timothy J. , McCormack Grace , Shepard Mark
Published: July 2021

Insurance markets often feature consumer sorting along both an extensive margin (whether to buy) and an intensive margin (which plan to buy). We present a new graphical theoretical framework that extends a workhorse model to incorporate both selection margins simultaneously. A key insight from our framework is that policies aimed at addressing one margin of selection often involve an economically meaningful trade-off on the other margin in terms of prices, enrollment, and welfare. Using data from Massachusetts, we illustrate these trade-offs in an empirical sufficient statistics approach that is tightly linked to the graphical framework we develop.
The Four-Equation New Keynesian Model
Authors: Sims Eric , Wu Jing Cynthia , Zhang Ji
Published: July 2021

This paper develops a New Keynesian model featuring financial intermediation, short- and long-term bonds, credit shocks, and scope for unconventional monetary policy. The log-linearized model reduces to four equations: Phillips and IS curves, as well as policy rules for the short-term interest rate and the central bank's long-bond portfolio (QE). Credit shocks and QE appear in both the IS and Phillips curves. In equilibrium, optimal monetary policy entails adjusting the short-term interest rate to offset natural rate shocks but using QE to offset credit market disruptions. Use of QE significantly mitigates the costs of a binding zero lower bound.
Six new combinations and one new natural hybrid of ferns from Sri Lanka
Authors: RAJAPAKSHA RANIL
Published: July 2021

Six new combinations are made for the ferns of Sri Lanka, including families Aspleniaceae (Hymenasplenium amoenum), Cyatheaceae (Alsophila sledgei and A. srilankensis) and Thelypteridaceae (Christella × parahispidula, Christella sledgei, Metathelypteris dassanayakei), and one new natural hybrid from the family Thelypteridaceae (Christella × fraser-jenkinsii) is proposed based on morphological and distributional evidence.
The Problem of Diagnosing Jet Waveguidability in the Presence of Large-Amplitude Eddies
Authors: Wirth Volkmar , Polster Christopher
Published: July 2021

The waveguidability of an upper-tropospheric zonal jet quantifies its propensity to duct Rossby waves in the zonal direction. This property has played a central role in previous attempts to explain large wave amplitudes and the subsequent occurrence of extreme weather. In these studies, waveguidability was diagnosed with the help of ray tracing arguments using the zonal average of the observed flow as the relevant background state. Here, it is argued that this method is problematic both conceptually and mathematically. The issue is investigated in the framework of the nondivergent barotropic model. This model allows the straightforward computation of an alternative “zonalized” background state, which is obtained through conservative symmetrization of potential vorticity contours and that is argued to be superior to the zonal average. Using an idealized prototypical flow configuration with large-amplitude eddies, it is shown that the two different choices for the background state yield very different results; in particular, the zonal-mean background state diagnoses a zonal waveguide, while the zonalized background state does not. This result suggests that the existence of a waveguide in the zonal-mean background state is a consequence of, rather than a precondition for, large wave amplitudes, and it would mean that the direction of causality is opposite to the usual argument. The analysis is applied to two heatwave episodes from summer 2003 and 2010, yielding essentially the same result. It is concluded that previous arguments about the role of waveguidability for extreme weather need to be carefully reevaluated to prevent misinterpretation in the future.
Early Peak of Latent Heat Fluxes Regulates Diurnal Temperature Range in Montane Cloud Forests
Authors: Gu Rong-Yu , Lo Min-Hui , Liao Chi-Ya , Jang Yi-Shin , Juang Jehn-Yih , Huang Cho-Ying , Chang Shih-Chieh , Hsieh Cheng-I , Chen Yi-Ying , Chu Housen , Chang Kuang-Yu
Published: July 2021

Hydro-climate in the montane cloud forest (MCF) regions is unique for its frequent fog occurrence and abundant water interception by tree canopies. Latent heat (LH) flux, the energy flux associated with evapotranspiration (ET), plays an essential role in modulating energy and hydrological cycles. However, how LH flux is partitioned between transpiration (stomatal evaporation) and evaporation (non-stomatal evaporation), and how it impacts local hydro-climate remain unclear. In this study, we investigate how fog modulates the energy and hydrological cycles of MCF by using a combination of in-situ observations and model simulations. We compare LH flux and associated micrometeorological conditions at two eddy-covariance sites—Chi-Lan (CL), a MCF, and Lien-Hua-Chih (LHC), a non-cloud forest in Taiwan. The comparison between the two sites reveals an asymmetric LH flux with an early peak at 9:00 in CL as opposed to LHC, where LH flux peaks at noon. The early peak of LH flux and its evaporative cooling dampen the increase in near-surface temperature during the morning hours in CL. The relatively small diurnal temperature range, abundant moisture brought by the valley wind, and local ET result in frequent afternoon fog formation. Fog water is then intercepted by the canopy, sustaining moist conditions throughout the night. To further illustrate this hydrological feedback, we used a land surface model to simulate how varying canopy water interception can affect surface energy and moisture budgets. Our study highlights the unique hydro-climatological cycle in MCF and, specifically, the inseparable relationship between the canopy and near-surface meteorology during the diurnal cycle.
Relationship of Convection Initiation and Subsequent Storm Strength to Ensemble Simulated Environmental Conditions during IOP3b of VORTEX Southeast 2017
Authors: Trier Stanley B. , Romine Glen S. , Ahijevych David A. , Sobash Ryan A. , Chasteen Manda B.
Published: July 2021

A 50-member convection-allowing ensemble was used to examine environmental factors influencing afternoon convection initiation (CI) and subsequent severe weather on 5 April 2017 during intensive observing period (IOP) 3b of the Verification of the Origins of Rotation in Tornadoes Experiment in the Southeast (VORTEX-SE). This case produced several weak tornadoes (rated EF1 or less), and numerous reports of significant hail (diameter ≥ 2 in.; ≥~5 cm), ahead of an eastward-moving surface cold front over eastern Alabama and southern Tennessee. Both observed and simulated CI was facilitated by mesoscale lower-tropospheric ascent maximized several tens of kilometers ahead of the cold-frontal position, and the simulated mesoscale ascent was linked to surface frontogenesis in the ensemble mean. Simulated maximum 2–5 km AGL updraft helicity (UHmax) was used as a proxy for severe-weather-producing mesocyclones, and considerable variability in UHmax occurred among the ensemble members. Ensemble members with UHmax > 100 m2 s−2 had stronger mesoscale ascent than in members with UHmax < 75 m2 s−2, which facilitated timelier CI by producing greater adiabatic cooling and moisture increases above the PBL. After CI, storms in the larger UHmax members moved northeastward toward a mesoscale region with larger convective available potential energy (CAPE) than in smaller UHmax members. The CAPE differences among members were influenced by differences in the location of an antecedent mesoscale convective system, which had a thermodynamically stabilizing influence on the environment toward which storms were moving. Despite providing good overall guidance, the model ensemble overpredicted severe weather likelihoods in northeastern Alabama, where comparisons with VORTEX-SE soundings revealed a positive CAPE bias.
Farmers’ perception, adaptation to groundwater salinity, and climate change vulnerability: insights from North India
Authors: Mitra Susmita , Mehta Pradeep K. , Mishra Sudipta Kumar
Published: July 2021

Groundwater salinity, caused by over-extraction and aggravated by climate change, negatively affects crop productivity and threatens global food security. Poor farmers are vulnerable due to low adaptive capacity. A better understanding of their perceptions and adaptation is important to inform policies for successful adaptation. This paper represents an important study by exploring the same in Mewat, a salinity-affected socioeconomically backward district of northern India. The study uses a mixed-method approach with both secondary data and a primary survey of 250 farmers. A large number of farmers perceived negative impacts on water, crop, income, and assets; and adapt in various ways like water management, crop, and land management, livelihood diversification, and shift towards surface water irrigation. Perceived impacts differed between richer and poorer farmers, whereas adaptation measures varied across the educational, social, and economic backgrounds of farmers. Lack of awareness, education, skill development, and livelihood-opportunities are found to be hindrances, whereas institutional and infrastructural support as facilitators of adaptation. Comparing the findings with global experiences we argued that developed countries intervene more in the policy level and infrastructure, whereas in developing countries, adaptation strategies are local, context-specific, and low-cost. The insights from our study will be useful for intervention in Mewat and similar areas across the developing world. We further argue that farmers take adaptation decisions based on perceived impacts and cost-benefit analysis. Therefore, future research work on quantifying the negative impacts and cost-benefit analysis of various adaptation measures will be useful to ensure successful adaptation in the region and beyond.
An Anglican ethic for the COVID-19 pandemic
Authors: Jones Christopher D.
Published: July 2021

The health risks associated with the COVID-19 pandemic have changed daily life tremendously. Many are uncertain how to respond due to conflicting advice from authorities, and the practical difficulties inherent in protecting human health while sustaining the economy. The Anglican tradition offers a moral framework, practical principles, and a method of public engagement to address the challenges of COVID-19. Kenneth Kirk provides a framework of virtue and spiritual practices and a method of moral reasoning that resolves problems of conscience. William Temple develops principles of love, justice, human dignity, the common good, and the preferential option for the vulnerable that can be applied to concrete cases. Nigel Biggar and Pauli Murray show how to engage the public from an Anglican perspective to spark conversations and create structures that address the pandemic. The result is flexible guidance that can be tailored to the needs of particular persons and communities.
Simple Ultraviolet–Visible Spectroscopy-Based Assay for Fast Evaluation of Magnetic Nanoparticle Selectivity Changes After Doping
Authors: Sikorski Jacek , Obarski Norbert , Trzaskowski Maciej , Matczuk Magdalena
Published: July 2021

Simple ultraviolet–visible spectroscopy-based methodology was proposed and utilized for the initial characterization of potential changes in selectivity of doped magnetic nanoparticles. Doped and undoped iron(II,III) (Fe3O4) magnetic nanoparticles were synthesized by the coprecipitation method. The doping processes of nanoparticles were confirmed using optical emission spectrometry, while the sizes of undoped and Cu-doped nanoparticles were investigated using a high-resolution field emission scanning electron microscope. The average diameters of nanoparticles were 8.34±1.78 nm and 9.12±1.93 nm, for doped and undoped materials, respectively. The influence of the nanoparticle's doping on their selectivity towards chosen analyte was monitored by the spectral techniques such as ultraviolet–visible and optical emission spectrometry. The interaction between Cu-doped Fe3O4 nanoparticles and cuprizone (a compound forming the characteristic colorful complex with copper) was confirmed. The elaborated studies proved the potential of ultraviolet–visible spectroscopy for the fast qualification of magnetic nanoparticles in terms of their ability to separate the selected analyte from the sample matrix.
Prevalence of antidepressant use and unmedicated depression in pregnant New Zealand women
Authors: Svardal Charlotte A , Waldie Karen , Milne Barry , Morton Susan MB , D’Souza Stephanie
Published: July 2021

Background:

Throughout pregnancy, women are at an increased risk of depression, with prevalence estimates between 6.5% and 18%. Global prevalence of antenatal antidepressant use is considerably lower at 3%.

Objective:

The present study determined the proportion of women taking antidepressants across pregnancy in New Zealand. We investigated whether variation exists across age bands, area-level deprivation and ethnicities, and identified how many women experienced unmedicated depression.

Method:

Antenatal data ( n = 6822) consisted of primarily third-trimester interviews conducted with mothers participating in Growing Up in New Zealand, a longitudinal study investigating child development. Women were asked about their antidepressant intake during pregnancy and assessed on antenatal depression symptoms using the Edinburgh Postnatal Depression Scale. Antidepressant use data were also compared to population-level data from Statistics New Zealand’s Integrated Data Infrastructure.

Results:

Antidepressant prevalence across pregnancy was 3.2%, with a 2.7% prevalence in trimester one and 2.6% following the first trimester. There was no significant difference in usage within age bands and area-level deprivation quintiles. Ethnicity-specific data revealed that Pasifika and Asian ethnicities had the lowest antidepressant use, and New Zealand Europeans the highest. The rate of unmedicated depression, where women met the Edinburgh Postnatal Depression Scale criteria for significant depressive symptoms but did not receive antidepressants during pregnancy, was 11.8%, indicating that antenatal depression treatment may be inadequate. Greater rates of unmedicated depression were seen for younger women (⩽24 years), those living in high deprivation areas and mothers of Pasifika, Asian and Māori ethnicities.

Conclusions:

Antenatal antidepressant use in New Zealand follows global prevalence estimates and highlights possible undertreatment of antenatal depression in New Zealand. Future research including other treatment types (e.g. behavioural therapy) is needed to evaluate whether undertreatment occurs across all treatment options.
The health service contact patterns of people with psychotic and non-psychotic forms of severe mental illness in New South Wales, Australia: A record-linkage study
Authors: Cvejic Rachael C , Srasuebkul Preeyaporn , Walker Adrian R , Reppermund Simone , Lappin Julia M , Curtis Jackie , Samaras Katherine , Dean Kimberlie , Ward Philip , Trollor Julian N
Published: July 2021

Objective:

To describe and compare the health profiles and health service use of people hospitalised with severe mental illness, with and without psychotic symptoms.

Methods:

We conducted a historical cohort study using linked administrative datasets, including data on public hospital admissions, emergency department presentations and ambulatory mental health service contacts in New South Wales, Australia. The study cohort comprised 169,306 individuals aged 12 years and over who were hospitalised at least once with a mental health diagnosis between 1 July 2002 and 31 December 2014. Of these, 63,110 had a recorded psychotic illness and 106,196 did not. Outcome measures were rates of hospital, emergency department and mental health ambulatory service utilisation, analysed using Poisson regression.

Results:

People with psychotic illnesses had higher rates of hospital admission (adjusted incidence rate ratio (IRR) 1.26; 95% confidence interval [1.23, 1.30]), emergency department presentation (adjusted IRR 1.17; 95% confidence interval [1.13, 1.20]) and ambulatory mental health treatment days (adjusted IRR 2.90; 95% confidence interval [2.82, 2.98]) than people without psychotic illnesses. The higher rate of hospitalisation among people with psychotic illnesses was driven by mental health admissions; while people with psychosis had over twice the rate of mental health admissions, people with other severe mental illnesses without psychosis (e.g. mood/affective, anxiety and personality disorders) had higher rates of physical health admissions, including for circulatory, musculoskeletal, genitourinary and respiratory disorders. Factors that predicted greater health service utilisation included psychosis, intellectual disability, greater medical comorbidity and previous hospitalisation.

Conclusion:

Findings from this study support the need for (a) the development of processes to support the physical health of people with severe mental illness, including those without psychosis; (b) a focus in mental health policy and service provision on people with complex support needs, and (c) improved implementation and testing of integrated models of care to improve health outcomes for all people experiencing severe mental illness.
“The lantern of the world rises to mortals by varied paths”: Paul Laffoley (1935–2015) and Dante
Authors: Saiber Arielle
Published: July 2021

American artist and architect Paul Laffoley (1935–2015) had a life-long fascination with Dante. Not only did he refer to Dante and the Commedia throughout his writings and paintings, but he created a large-scale triptych illustrating the poem, as well as sketched out plans for a full-immersion Dante study center on a planetoid orbiting the Sun, complete with a to-scale replica of the medieval Earth, Mount Purgatory, the material heavens, and the Empyrean through which a “Dante Candidate” could re-enact the Pilgrim’s journey. Laffoley’s work is often placed by art critics within the visionary tradition and Laffoley himself embraced that label, even as he deconstructed the term in his writing. Among the many visionary artists, poets, and philosophers Laffoley studied, Dante was central. He was, for Laffoley, a model seeker of knowledge, a seer beyond the illusions of everyday life. The essay that follows offers a brief biography of Laffoley and his works; an overview of his two main Dante projects ( The Divine Comedy triptych [1972–1975] and The Dantesphere [1978]); and initial considerations on how Dante’s works and thought fit into Laffoley’s larger epistemological project.
Teacher’s Assessment of Gender Differences in School Performance, Social Skills, and Externalizing Behavior From Fourth Through Seventh Grade
Authors: Ogden Terje , Olseth Asgeir , Sørlie Mari-Anne , Hukkelberg Silje
Published: July 2021

Gender differences in teacher ratings of academic performance, social skills, and externalizing behavior were examined from fourth through seventh grade in a group of 1,023 students from 65 primary schools. Cohen’s d and t tests and were used to report the magnitude of gender differences, and structural equation modeling was used to evaluate cross-domain influences in latent cascade models. Girls received significantly more positive teacher ratings than boys, but the differences leveled more out in the social and behavioral domain than in the academic. Teacher assessments of academic performance predicted future social skills to a larger extent than vice versa for both genders.
Establishment of a national DNA database in the Republic of Serbia: Legal aspects and implications for the future
Authors: Teodorović Smilja , Bošković Aleksandar
Published: July 2021

Forensic DNA databases have been established in the vast majority of European countries and represent an essential personal identification instrument in the criminal justice system. The implementation of suitable legislation and accompanying legal practice is an imperative to ensure sensible use of the DNA repository, without interfering with the rights, freedoms and privacy of individuals and their families. Thus, the complex matter of DNA databank effectiveness and intrusiveness is a delicate balancing act, which has resulted in diverse database governing regimes among different countries. In 2018, the National Assembly of the Republic of Serbia passed the first Law on the National DNA Register, which was created by the Ministry of Interior. This short and imprecise regulation was announced without prior consultation with professional stakeholders or the public, resulting in controversy. In this article, we examine essential questions pertinent to launching a forensic DNA database through the lens of the new Law on the National DNA Register in the Republic of Serbia and in comparison to the other European approaches and guidelines to regulating forensic DNA repositories. We further discuss the resulting legal, social and ethical implications and concerns and propose future actions intended to improve the legal framework. We believe that stimulating such discussions throughout the scientific and professional community will result in the advancement of DNA profiling and databasing in a future European Union member state and, more generally, the manner in which biological data are managed in various countries, particularly those that are developing.
Short-course vasoconstrictors are adequate for esophageal variceal bleeding after endoscopic variceal ligation: A systematic review and meta-analysis
Authors: Yeh Jen-Hao , Lo Gin-Ho , Huang Ru-Yi , Lin Chih-Wen , Wang Wen-Lun , Perng Daw-Shyong
Published: July 2021

Endoscopic variceal ligation (EVL) with vasoconstrictors has been recommended for acute esophageal variceal bleeding. However, the optimal duration of vasoconstrictors after EVL is controversial. This systematic review and meta-analysis was conducted to explore the efficacy of short-course vasoconstrictors (≤3 days) versus standard combination (3–5 days). A comprehensive literature review was conducted using the PubMed, Embase, and Cochrane library databases with subsequent meta-analysis. The primary outcomes were 5-day rebleeding, mortality, and treatment failure rates. A risk ratio (RR) with 95% confidence interval is used for outcome comparison. Nine randomized studies with 838 patients were included. The initial hemostasis (96.8% vs 97.4%, p = 0.919), 5-day rebleeding (11.2% vs 8.3%, RR = 1.05, 95% CI = 0.62–1.76), mortality (0 vs 1.3%, RR = 0.48, 95% CI = 0.10–2.39), and treatment failure (7.4% vs 5.9%, RR = 1.10, 95% CI = 0.48–2.49) were similar in both groups. Subgroup analysis suggested EVL alone had no significant difference of 5-day re-bleeding (15.9% vs 7.1%, RR = 2.25, 95% CI = 0.87–5.77), mortality (0 vs 0.7%, RR = 0.71, 95% CI = 0.08–6.03), treatment failure (9.6% vs 6.7%, RR = 1.43, 95% CI = 0.54–3.75) compared to standard combination. Clinical heterogeneity was found for the rebleeding rate for the subgroup during sensitivity analysis. EVL with short-course vasoconstrictors is highly efficacious for esophageal variceal bleeding. Further studies are required to determine the genuine need of subsequent vasoconstrictor after successful EVL.
Two-Year College Students Report Multiple Benefits From Participation in an Integrated Geoscience Research, Coursework, and Outreach Internship Program
Authors: Stofer Kathryn A. , Chandler Jhenai W. , Insalaco Stephanie , Matyas Corene , Lannon Heidi J. , Judge Jasmeet , Lanman Brandan , Hom Bobby , Norton Heather
Published: July 2021

Objective: Despite the availability of high-paying, high-demand careers, few women and students from underrepresented racial and ethnic minorities enter undergraduate programs understanding what the geosciences are and associated available career opportunities. This problem is compounded for students from backgrounds underrepresented in the United States. High-impact practices, such as mentoring, internships, undergraduate research experiences, and cohort-building, increase recruitment and retention of underrepresented students in science, technology, engineering, and math at 4-year institutions. What is not yet clear is the impact these interventions have on underrepresented students at two-year colleges, where the STEM pathway has become a main postsecondary school entry point for these students due to the affordability, flexibility, and academic support provided. Therefore, we designed, implemented, and researched a year-long program providing underrepresented students at a two-year college exposure to several of these experiences. Methods: We interviewed program participants about their perceptions and experiences in the program. Analysis proceeded using constant comparison. Results: Participants reported benefits from networking opportunities, gains in confidence, and gains in job skills, while some reported challenges for participation such as communication and time expectation conflicts; participants also struggled to balance the program with employment needs on top of school requirements. Different aspects of the program benefited different students, suggesting that all of these experiences could support recruitment and foster interest in geoscience for underrepresented students at two-year colleges. Conclusion: We conclude with implications for future research, program enhancements, and time constraint and mentoring needs related to characteristics of two-year college students.
Bibliometric Analysis of Suicide Research Among Black Youth
Authors: Mushunje Rumbidzai , Graves Scott L.
Published: July 2021

Historically, Black youth have had lower rates of suicide attempts in comparison to their peers; however, in recent years this rate has changed, with self-reported suicide attempts for Black adolescents rising by 73%. The purpose of this study was to analyze the characteristics of research on Black youth and suicide using bibliometric techniques. To conduct our analysis, we developed a search strategy utilizing the Scopus database for the time period from 1980 to 2020. Results indicated an increasing trend in the number of articles published each year related to Black youth and suicide. The most highly productive journals were the Suicide and Life Threatening Behavior, Pediatrics, and Journal of Youth and Adolescence. Authors who frequently published in this area include Nadine Kaslow, Rheeda Walker, and Sean Joe. While this research area is growing, there is a lack of published articles focused on interventions for suicide prevention and non-comparative race specific research focused on Black youth.