bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Proteomics Profiling Illuminates the Fruitlet Abscission Mechanism of Sweet Cherry as Induced by Embryo Abortion
Authors: Qiu Zhi-Lang , Wen Zhuang , Yang Kun , Tian Tian , Qiao Guang , Hong Yi , Wen Xiao-Peng
Published: February 2020

Sweet cherry (Prunus avium L.) is a delicious nutrient-rich fruit widely cultivated in countries such as China, America, Chile, and Italy. However, the yield often drops severely due to the frequently-abnormal fruitlet abscission, and few studies on the metabolism during its ripening process at the proteomic level have been executed so far. To get a better understanding regarding the sweet cherry abscission mechanism, proteomic analysis between the abscising carpopodium and non-abscising carpopodium of sweet cherry was accomplished using a newly developed Liquid chromatography-mass spectrometry/mass spectrometry with Tandem Mass Tag (TMT-LC-MS/MS) methodology. The embryo viability experiments showed that the vigor of the abscission embryos was significantly lower than that of retention embryo. The activity of cell wall degrading enzymes in abscising carpopodium was significantly higher than that in non-abscising carpopodium. The anatomy results suggested that cells in the abscission zone were small and separated. In total, 6280 proteins were identified, among which 5681 were quantified. It has been observed that differentially accumulated proteins (DAPs) influenced several biological functions and various subcellular localizations. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that plenty of metabolic pathways were notably enriched, particularly those involved in phytohormone biosynthesis, cell wall metabolism, and cytoskeletal metabolism, including 1-aminocyclopropane-1-carboxylate oxidase proteins which promote ethylene synthesis, and proteins promoting cell wall degradation, such as endoglucanases, pectinase, and polygalacturonase. Differential expression of proteins concerning phytohormone biosynthesis might activate the shedding regulation signals. Up-regulation of several cell wall degradation-related proteins possibly regulated the shedding of plant organs. Variations of the phytohormone biosynthesis and cell wall degradation-related proteins were explored during the abscission process. Furthermore, changes in cytoskeleton-associated proteins might contribute to the abscission of carpopodium. The current work represented the first study using comparative proteomics between abscising carpopodium and non-abscising carpopodium. These results indicated that embryo abortion might lead to phytohormone synthesis disorder, which effected signal transduction pathways, and hereby controlled genes involved in cell wall degradation and then caused the abscission of fruitlet. Overall, our data may give an intrinsic explanation of the variations in metabolism during the abscission of carpopodium.
Molecular Mechanisms Involved in the Impairment of Boar Sperm Motility by Peroxynitrite-Induced Nitrosative Stress
Authors: Serrano Rebeca , Garrido Nicolás , Céspedes Jose A. , González-Fernández Lauro , García-Marín Luis J. , Bragado María J.
Published: February 2020

Excessive levels of reactive nitrogen species (RNS) produce nitrosative stress. Among RNS is peroxynitrite, a highly reactive free radical generated when nitric oxide reacts with superoxide anion. Peroxynitrite effects have been mainly studied in somatic cells, and in spermatozoa the majority of studies are focused in humans. The aim of this study is to investigate the in vitro peroxynitrite effect on boar spermatozoa functions and the molecular mechanisms involved. Spermatozoa were exposed to the donor 3-morpholinosydnonimine (SIN-1) in non-capacitating or capacitating medium, motility was evaluated by CASA, functional parameters by flow cytometry and sperm protein phosphorylation by Western blotting. SIN-1 treatment, that significantly increases peroxynitrite levels in boar spermatozoa, potentiates the capacitating-stimulated phosphorylation of cAMP-dependent protein kinase 1 (PKA) substrates and GSK-3α. SIN-1 induced peroxynitrite does not decrease sperm viability, but significantly reduces sperm motility, progressive motility, velocities and motility coefficients. Concomitantly, peroxynitrite does not affect mitochondrial membrane potential, plasma membrane fluidity, or A23187-induced acrosome reaction. However, peroxynitrite significantly increases sperm lipid peroxidation in both media. In conclusion, peroxynitrite compromises boar sperm motility without affecting mitochondrial activity. Although peroxynitrite potentiates the phosphorylation of pathways leading to sperm motility, it also causes oxidative stress that might explain, at least partially, the motility impairment.
Similarity Analysis of Learning Interests among Majors Using Complex Networks
Authors: Zhang Qiang , Zhang Xujuan , Gong Linli , Li Zhigang , Zhang Qingqing , Chen Wanghu
Published: February 2020

At present, multi-specialization cross integration is the new trend for high-level personnel training and scientific and technological innovation. A similarity analysis of learning interests among specializations based on book borrowing behavior is proposed in this paper. Students of different majors that borrow the same book can be regarded as a way of measuring similar learning interests among majors. Considering the borrowing data of 75 majors, 14,600 undergraduates, and 280,000 books at the Northwest Normal University (NWNU), as an example, this study classified readers into majors depending on similarity among students. A complex network of similar learning interests among specializations was constructed using group behavior data. The characteristics of learning interests were revealed among majors through a network topology analysis, importance of network nodes, and calculation of the similarity among different majors by the Louvain algorithm. The study concluded that the major co-occurrence network was characterized as scale-free and small-world; most majors had mutual communication and an infiltrating relationship, and the 75 majors of NWNU may form six major interest groups. The conclusions of the study were related to the development of majors of the university, and a match between major learning communities was based on the borrowing interest in a similar network to reflect the relationship between the characteristics and internal operating rules of a major.
Wireless Underground Communications in Sewer and Stormwater Overflow Monitoring: Radio Waves through Soil and Asphalt Medium
Authors: Raza Usman , Salam Abdul
Published: February 2020

Storm drains and sanitary sewers are prone to backups and overflows due to extra amount wastewater entering the pipes. To prevent that, it is imperative to efficiently monitor the urban underground infrastructure. The combination of sensors system and wireless underground communication system can be used to realize urban underground IoT applications, e.g., storm water and wastewater overflow monitoring systems. The aim of this article is to establish a feasibility of the use of wireless underground communications techniques, and wave propagation through the subsurface soil and asphalt layers, in an underground pavement system for storm water and sewer overflow monitoring application. In this paper, the path loss analysis of wireless underground communications in urban underground IoT for wastewater monitoring has been presented. The dielectric properties of asphalt, sub-grade aggregates, and soil are considered in the path loss analysis for the path loss prediction in an underground sewer overflow and wastewater monitoring system design. It has been shown that underground transmitter was able to communicate through thick asphalt (10 cm) and soil layers (20 cm) for a long range of up to 4 km.
Within-Stand Distribution of Tree Mortality Caused by Mountain Pine Beetle, Dendroctonus ponderosae Hopkins
Authors: Negrón José F.
Published: February 2020

The mountain pine beetle (MPB) (Dendroctonus ponderosae) is a bark beetle that attacks and kills ponderosa pine (Pinus ponderosa), among other pine species throughout the western conifer forests of the United States and Canada, particularly in dense stands comprising large trees. There is information on the stand conditions that the insect prefers. However, there is a paucity of information on how small-scale variation in stand conditions influences the distribution of tree mortality within a stand. I examined the small-scale distribution of ponderosa pine basal area pre- and post a mountain pine beetle infestation, and used geostatistical modeling to relate the spatial distribution of the host to subsequent MPB-caused tree mortality. Results indicated increased mortality in the denser parts of the stand. Previous land management has changed historically open low-elevation ponderosa pine stands with aggregated tree distribution into dense stands that are susceptible to mountain pine beetles and intense fires. Current restoration efforts are aimed at reducing tree density and leaving clumps of trees, which are more similar to historical conditions. The residual clumps, however, may be susceptible to mountain pine beetle populations. Land managers will want to be cognizant of how mountain pine beetles will respond to restoration treatments, so as to prevent and mitigate tree mortality that could negate restoration efforts.
Using RNA Interference to Reveal the Function of Chromatin Remodeling Factor ISWI in Temperature Tolerance in Bemisia tabaci Middle East–Asia Minor 1 Cryptic Species
Authors: Ji Shun-Xia , Wang Xiao-Di , Shen Xiao-Na , Liang Lin , Liu Wan-Xue , Wan Fang-Hao , Lü Zhi-Chuang
Published: February 2020

Invasive species often encounter rapid environmental changes during invasions and only the individuals that successfully overcome environmental stresses can colonize and spread. Chromatin remodeling may be essential in environmental adaptation. To assess the functions of imitation switch (ISWI) in invasive Bemisia tabaci Middle East–Asia Minor 1 (MEAM1) cryptic species, we cloned and characterized the MEAM1 BtISWI gene and determined its functions in response to thermal stress. The full-length cDNA of BtISWI was 3712 bp, with a 3068 bp open reading frame (ORF) encoding a 118.86 kDa protein. BtISWI mRNA expression was significantly up-regulated after exposure to heat shock or cold shock conditions, indicating that BtISWI expression can be induced by thermal stress. After feeding double-stranded RNA (dsRNA), specifically for BtISWI, resistance to both heat and cold decreased significantly, suggesting that BtISWI may function directly in the thermal tolerance of MEAM1. Moreover, the preferred temperature of MEAM1 adults fed dsRNA was 1.9–3.5 °C higher than the control groups. Taken together, our findings highlight the importance of epigenetic gene regulation in the thermal response or thermal adaptation of invasive Bemisia tabaci (B. tabaci), and provide a new potential target for establishing sustainable control strategies for B. tabaci.
The Influence of Visual and Olfactory Cues in Host Selection for Bemisia tabaci Biotype B in the Presence or Absence of Tomato Yellow Leaf Curl Virus
Authors: Johnston Nicholas , Martini Xavier
Published: February 2020

The silverleaf whitefly, Bemisia tabaci, is one of the most destructive agricultural pests in the world, vectoring a large number of devastating viruses, including Tomato Yellow Leaf Curl Virus (TYLCV). When selecting a host, B. tabaci is primarily influenced by a range of visual and olfactory cues. Therefore, elucidating how such cues become modified in the presence of whitefly-vectored begomoviruses is critical to better understanding the epidemiology of many economically important diseases. The goal of this study was to determine how both visual and odor cues interact in the presence of TYLCV. In Y-tube olfactometer assays, whiteflies were submitted to a range of isolated visual and olfactory cues to determine behavioral changes. B. tabaci choices were then compared to both stimuli combined in the presence or absence of TYLCV. Under visual stimuli only, B. tabaci exhibited a visual attraction to the color yellow, TYLCV-infected tomato leaves, and TYLCV-infected tomato volatiles. Attraction was the strongest overall when both visual and olfactory cues from TYLCV-symptomatic tomato plants were combined, as opposed to a single isolated cue. These results highlight the importance of both sensory stimuli during B. tabaci host selection in the presence of an associated begomovirus.
Phenology of the Diamondback Moth (Plutella xylostella) in the UK and Provision of Decision Support for Brassica Growers
Authors: Wainwright Charlotte , Jenkins Sascha , Wilson Daniel , Elliott Marian , Jukes Andrew , Collier Rosemary
Published: February 2020

In the UK, severe infestations by Plutella xylostella occur sporadically and are due mainly to the immigration of moths. The aim of this study was to develop a more detailed understanding of the phenology of P. xylostella in the UK and investigate methods of monitoring moth activity, with the aim of providing warnings to growers. Plutella xylostella was monitored using pheromone traps, by counting immature stages on plants, and by accessing citizen science data (records of sightings of moths) from websites and Twitter. The likely origin of migrant moths was investigated by analysing historical weather data. The study confirmed that P. xylostella is a sporadic but important pest, and that very large numbers of moths can arrive suddenly, most often in early summer. Their immediate sources are countries in the western part of continental Europe. A network of pheromone traps, each containing a small camera sending images to a website, to monitor P. xylostella remotely provided accessible and timely information, but the particular system tested did not appear to catch many moths. In another approach, sightings by citizen scientists were summarised on a web page. These were accessed regularly by growers and, at present, this approach appears to be the most effective way of providing timely warnings.
Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans
Authors: Burska Agata N. , Giannoudis Peter V. , Tan Boon Hiang , Ilas Dragos , Jones Elena , Ponchel Frederique
Published: February 2020

To characterise the dynamic of events during the early phases of fracture repair in humans, we investigated molecular events using gene expression profiling of bone fragments from the fracture site at different time points after trauma and immune/stromal cells recruitment at the fracture site using flow cytometry. Bone and inflammatory markers were expressed at low levels at homeostasis, while transcripts for bone constituent proteins were consistently detected at higher levels. Early after fracture (range 2–4 days), increased expression of CXCL12, suggested recruitment of immune cells associated with a change in the balance of degradation enzymes and their inhibitors. At intermediate time after fracture (4–8 days), we observed high expression of inflammatory cytokines (IL1-beta, IL6), CCL2, the T-cell activation marker CD69. Late after fracture (8–14 days), high expression of factors co-operating towards the regulation of bone turnover was detected. We identified potential soluble factors and explored circulating levels in patients for whom a union/non-union (U/NU) outcome was known. This showed a clear difference for PlGF (p = 0.003) at day 1. These findings can inform future studies further investigating the cascade of molecular events following fractures and for the prediction of fracture non-union.
Lidocaine vs. Other Local Anesthetics in the Development of Transient Neurologic Symptoms (TNS) Following Spinal Anesthesia: A Meta-Analysis of Randomized Controlled Trials
Authors: Koo Chang-Hoon , Shin Hyun-Jung , Han Sung-Hee , Ryu Jung-Hee
Published: February 2020

The use of lidocaine in spinal anesthesia may increase the risk of transient neurological symptoms (TNS) according to previous meta-analyses. However, the previous meta-analyses lacked data on some other local anesthetics and thus, more evaluations are still needed to compare the effect of lidocaine on the development of TNS. The objective of this study was to compare the risk of TNS according to lidocaine versus other local anesthetics in patients undergoing spinal anesthesia. A total of 39 randomized controlled trials with 4733 patients were analyzed. The incidence of TNS was 10.8% in the lidocaine group and was 2.2% in the control groups (risk ratio (RR) 4.12, 95% confidence interval (CI) 3.13 to 5.43, p < 0.001). In subgroup analysis, lidocaine increased the incidence of TNS compared with other local anesthetics except mepivacaine, ropivacaine or sameridine. The risk of TNS was higher in the hyperbaric (p < 0.001) or isobaric lidocaine (p < 0.001) group compared with the control group, but there were no differences found between the two groups when hypobaric lidocaine was administered (p = 1.00). This study confirmed that lidocaine for spinal anesthesia still causes TNS more frequently than most other local anesthetics, especially when hyperbaric or isobaric lidocaine was used.
Bu-M-P-ing Iron: How BMP Signaling Regulates Muscle Growth and Regeneration
Authors: Borok Matthew J , Mademtzoglou Despoina , Relaix Frederic
Published: February 2020

The bone morphogenetic protein (BMP) pathway is best known for its role in promoting bone formation, however it has been shown to play important roles in both development and regeneration of many different tissues. Recent work has shown that the BMP proteins have a number of functions in skeletal muscle, from embryonic to postnatal development. Furthermore, complementary studies have recently demonstrated that specific components of the pathway are required for efficient muscle regeneration.
Cerium Dioxide Particles to Tune Radiopacity of Dental Adhesives: Microstructural and Physico-Chemical Evaluation
Authors: Garcia Isadora Martini , Leitune Vicente Castelo Branco , Takimi Antonio Shigueaki , Bergmann Carlos Pérez , Samuel Susana Maria Werner , Melo Mary Anne , Collares Fabrício Mezzomo
Published: February 2020

The insufficient radiopacity of dental adhesives applied under composite restorations makes the radiographic diagnosis of recurrent caries challenging. Consequently, the misdiagnosis may lead to unnecessary replacement of restorations. The aims of this study were to formulate experimental dental adhesives containing cerium dioxide (CeO2) and investigate the effects of different loadings of CeO2 on their radiopacity and degree of conversion for the first time. CeO2 was characterized by X-ray diffraction analysis, Fourier transforms infrared spectroscopy, and laser diffraction for particle size analysis. Experimental dental adhesives were formulated with CeO2 as the inorganic filler with loadings ranging from 0.36 to 5.76 vol.%. The unfilled adhesive was used as a control. The studied adhesives were evaluated for dispersion of CeO2 in the polymerized samples, degree of conversion, and radiopacity. CeO2 presented a monoclinic crystalline phase, peaks related to Ce-O bonding, and an average particle size of around 16 µm. CeO2 was dispersed in the adhesive, and the addition of these particles increased the adhesives’ radiopacity (p < 0.05). There was a significant decrease in the degree of conversion with CeO2 loadings higher than 1.44 vol.%. However, all materials showed a similar degree of conversion in comparison to commercially available adhesives. CeO2 particles were investigated for the first time as a promising compound to improve the radiopacity of the dental adhesives.
Reducing Vulnerability to Desertification by Using the Spatial Measures in a Degraded Area in Thailand
Authors: Wijitkosum Saowanee
Published: February 2020

The process of desertification is complex, involving interaction between many factors, both environmental and anthropogenic. However, human activities, especially from land-use change and inappropriate land use, are the most influential factors associated with the desertification risk. This study was conducted in Huay Sai, a degraded land in Thailand. The Environmentally Sensitive Area Index (ESAI) model incorporating Geogracphic Information System (GIS) was applied to investigate and map the desertification sensitivity area. The study aimed to analyze and assess measures to reduce the desertification risk. This study emphasized three group factors with nine subcriteria influencing desertification risk: soil (texture, fertility, drainage, slope gradient, and depth), climatic (precipitation and aridity index), and vegetation factors (land use and soil erosion). In terms of the required spatial measures to reduce the desertification vulnerability, policy and defensive measures that were closely related to drought and desertification of the area were considered. Three main measures covering soil and water conservation, soil improvement, and reforestation were implemented. The area development and restoration plans have been implemented continuously. The study found that 47.29% of the Huay Sai area was at a high risk, with a further 41.16% at a moderate risk. Implementation of three measures indicated that desertification risk was significantly decreased. Addressing the causes of the highest risk areas could help reduce the overall desertification risk at Huay Sai, where most areas would then be at either a moderate (61.04%) or low (32.43%) desertification risk with no severe- or high-risk areas. The success of the area restoration is from the formulation of a restoration and development plan that understands the local conditions. Moreover, the plan integrated the restoration of the soil, forests, and water together in order to restore the ecosystem so that the implementation was able to solve problems directly.
An Evolutionary Approach to Technology Innovation of Cadastre for Smart Land Management Policy
Authors: Choi Hae Ok
Published: February 2020

In this study, we attempted to quantitatively determine the characteristics of keyword networks in the cadastre field using major contents of research drawn from international academic papers. Furthermore, we investigated the macroscopic evolution of cadastral research and examined its keyword network in detail (at a global scale) using semantic analysis. The analysis was carried out based on cadastral-research-related publications extracted from “Scopus” for 1987 to 2019. It was found that cadastre research has closely followed the recent trend of a growing interest in research on geospatial information and standardization. The results showed the advancement of technology innovation within the field of cadastres, as highlighted in the combination of relevant keywords (mostly from those related to spatial information technology and participation of civilians). These new issues are expected to drive the evolution of the academic scope in the future through synthesis with other fields for smart land management policy.
Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis
Authors: Gajdács Márió , Bátori Zoltán , Ábrók Marianna , Lázár Andrea , Burián Katalin
Published: February 2020

Classical resistance classifications (multidrug resistance [MDR], extensive drug resistance [XDR], pan-drug resistance [PDR]) are very useful for epidemiological purposes, however, they may not correlate well with clinical outcomes, therefore, several novel classification criteria (e.g., usual drug resistance [UDR], difficult-to-treat resistance [DTR]) were introduced for Gram-negative bacteria in recent years. Microbiological and resistance data was collected for urinary tract infections (UTIs) retrospectively, corresponding to the 2008.01.01–2017.12.31. period. Isolates were classified into various resistance categories (wild type/susceptible, UDR, MDR, XDR, DTR and PDR), in addition, two new indicators (modified DTR; mDTR and mcDTR) and a predictive composite score (pMAR) were introduced. Results: n = 16,240 (76.8%) outpatient and n = 13,386 (69.3%) inpatient UTI isolates were relevant to our analysis. Citrobacter-Enterobacter-Serratia had the highest level of UDR isolates (88.9%), the Proteus-Providencia-Morganella group had the highest mDTR levels. MDR levels were highest in Acinetobacter spp. (9.7%) and Proteus-Providencia-Morganella (9.1%). XDR- and DTR-levels were higher in non-fermenters (XDR: 1.7%–4.7%. DTR: 7.3%–7.9%) than in Enterobacterales isolates (XDR: 0%–0.1%. DTR: 0.02%–1.5%). Conclusions: The introduction of DTR (and its’ modifications detailed in this study) to the bedside and in clinical practice will definitely lead to substantial benefits in the assessment of the significance of bacterial resistance in human therapeutics.
Degradation of Axial Ultimate Load-Bearing Capacity of Circular Thin-Walled Concrete-Filled Steel Tubular Stub Columns after Corrosion
Authors: Zhang Fengjie , Xia Junwu , Li Guo , Guo Zhen , Chang Hongfei , Wang Kejin
Published: February 2020

This work aimed to investigate the effects of steel tube corrosion on the axial ultimate load-bearing capacity (AULC) of circular thin-walled concrete-filled steel tubular (CFST) members. Circular thin-walled CFST stub column specimens were made of steel tubes with various wall-thicknesses. These CFST column specimens were subjected to an accelerated corrosion test, where the steel tubes were corroded to different degrees of corrosion. Then, these CFST specimens with corroded steel tubes experienced an axial static loading test. Results show that the failure patterns of circular thin-walled CFST stub columns with corroded steel tubes are different from those of the counterpart CFST columns with ordinary wall-thickness steel tubes, which is a typical failure mode of shear bulging with slight local outward buckling. The ultimate strength and plastic deformation capacity of the CFST specimens decreased with the increasing degree of steel corrosion. The failure modes of the specimens still belonged to ductile failure because of the confinement of outer steel tube. The degree of steel tube corrosion, diameter-to-thickness ratio, and confinement coefficient had substantial influences on the AULC and the ultimate compressive strength of circular thin-walled CFST stub columns. A simple AULC prediction model for corroded circular thin-walled CFST stub columns was presented through the regression of the experimental data and parameter analysis.
Effect of Diisocyanates as Compatibilizer on the Properties of BF/PBAT Composites by In Situ Reactive Compatibilization, Crosslinking and Chain Extension
Authors: Xie Xiwei , Zhang Caili , Weng Yunxuan , Diao Xiaoqian , Song Xinyu
Published: February 2020

Due to the hydrophobic nature of poly (butylene terephthalate) (PBAT), and the hydrophilic nature of bamboo flour (BF), a BF/PBAT (50/50) blend shows low mechanical properties, and especially shows poor impact strength. In order to increase the interfacial adhesion between BF and PBAT, diisocyanate was used as a reactive compatibilizer to modify bamboo powder. A series of BF/PBAT composites were prepared by the method of mixing and melting in an internal mixer. After adding reactive compatibilizer 4,4′-methylenebis(phenyl isocyanate) (MDI), BF/PBAT (50/50) composites with high mechanical properties were successfully prepared. The tensile strength, elongation at break, and impact strength of the BF/MDI-2/PBAT composite with 2 wt % MDI content were increased by 1.9, 6.8, and 4.3 times respectively over the BF/PBAT blend without the added MDI. The higher toughening effect of MDI in BF/PBAT composites can be mainly ascribed to the improved interface bonding between BF and PBAT. The isocyanate group of MDI can react with the hydroxyl group on the BF surface and in situ formation of the carbamate group on the BF surface. The residual isocyanate can then react with the hydroxyl group of PBAT and form carbamate groups. The rheological behaviors demonstrate that addition of appropriate amounts of MDI, 1 wt % and 2 wt %, can promote the flowability of the molten BF/PBAT composites due to the decrease in interparticle interaction between bamboo powder and the increase in the thermal motion of the molecules.
MgO-Lignin Dual Phase Filler as an Effective Modifier of Polyethylene Film Properties
Authors: Bula Karol , Kubicki Grzegorz , Jesionowski Teofil , Klapiszewski Łukasz
Published: February 2020

Functional magnesium oxide-lignin hybrid materials were obtained via mechanical grinding. Their particle shape and size as well as physicochemical properties were characterized. MgO-lignin materials with biocomponent content (between 20% and 80% amount of total weight of filler) were used as a partially bio-structured modifier of low density polyethylene. The composites with 5% by weight of dual fillers and polyethylene grafted with maleic anhydride were compounded in a twin screw extruder working in co-rotating mode. The prepared blends were cast extruded using a single screw extruder and laboratory cast line. The properties of the obtained films were verified in case of their weldability. The seal strength as well as shear test and tear strength of the welded sheets were examined. The results showed that the shortest equivalent time required to perform correct weld occurred in the system, where the highest amount of lignin was used in hybrid filler MgO-L (1:5 w/w). From mechanical tests of welds, a sharp increase in ultimate seal force was noticed for almost all compositions with lignin, especially where MgO was coupled with a high lignin content. For those composition seal open force raised up to 37.0 N, from the value of 23.6 N, achieved for neat low density polyethylene (LDPE). Tear strength of weld sheets confirmed once more that LDPE composition with MgO-L (1:5 w/w) achieved the highest ultimate force with its value of 71.5 N, and it was ~20.0 N higher than in the case of neat LDPE.
Solving Second-Order Linear Differential Equations with Random Analytic Coefficients about Regular-Singular Points
Authors: Cortés Juan-Carlos , Navarro-Quiles Ana , Romero José-Vicente , Roselló María-Dolores
Published: February 2020

In this contribution, we construct approximations for the density associated with the solution of second-order linear differential equations whose coefficients are analytic stochastic processes about regular-singular points. Our analysis is based on the combination of a random Fröbenius technique together with the random variable transformation technique assuming mild probabilistic conditions on the initial conditions and coefficients. The new results complete the ones recently established by the authors for the same class of stochastic differential equations, but about regular points. In this way, this new contribution allows us to study, for example, the important randomized Bessel differential equation.
Oxidant/Antioxidant Status of Breast Cancer Patients in Pre- and Post-Operative Periods
Authors: Didžiapetrienė Janina , Kazbarienė Birutė , Tikuišis Renatas , Dulskas Audrius , Dabkevičienė Daiva , Lukosevičienė Vaida , Kontrimavičiūtė Eglė , Sužiedėlis Kęstutis , Ostapenko Valerijus
Published: February 2020

Background and Objectives: The purpose of this study is to evaluate the level of oxidative stress before and after breast cancer surgery. Materials and Methods: Malondialdehyde (MDA) level was tested using a thiobarbituric acid (TBA) assay based on the release of a color complex due to TBA reaction with MDA. The glutathione S-transferase (GST) activity was evaluated by enzymatic conjugation of reduced glutathione (GSH) with 1-chloro-2,4-dinitrobenzene. The level of total glutathione (reduced GSH and oxidized GSSG) was detected using a recycling system by 5,5-dithiobis(2-nitrobenzoic acid). The levels of the indices were determined in the serum of 52 patients before surgery, two hours and five days after surgery, and in 42 healthy women. Results: In the patients over 50 years old the level of MDA was higher after surgery in comparison with before surgery, and GST activity was lower in comparison with the control. The GSH + GSSG level in both ages groups after surgery was lower than in the control. Significant differences of MDA level were detected in patients with stage III after surgery compared to the control. The level of GSH + GSSG was significantly lower in the patients with I–III stages compared to the control. Conclusion: The most expressed changes demonstrate the significance of MDA as a marker to evaluate oxidative stress in breast cancer patients. The degree of oxidative stress depends on the patient’s age and stage of disease. (1) Malondialdehyde can be used as an oxidative stress marker; (2) A higher stage of the disease and older age correspond to a higher rise of malondialdehyde, suggesting more intensive oxidative stress.
The Interplay between Vascular Function and Sexual Health in Prostate Cancer: The Potential Benefits of Exercise Training
Authors: Vear Natalie K. , Coombes Jeff S. , Bailey Tom G. , Skinner Tina L.
Published: February 2020

Prostate cancer and its associated treatments can cause significant and lasting morbidities, such as cardiovascular and sexual dysfunctions. Various interventions have attempted to prevent or mitigate these dysfunctions. This review summarises the available evidence on the effects of exercise training on markers of cardiovascular disease (as assessed via vascular health outcomes) and sexual health in this prevalent cancer population. Current studies predominantly report blood pressure outcomes as a marker of vascular health, as well as various questionnaires assessing sexual health parameters, in men on active treatment (i.e., hormone or radiation therapies) or post-treatment. Preliminary evidence suggests that exercise interventions may elicit improvements in sexual function, but not blood pressure, in these populations. Future studies in more advanced and varied prostate cancer populations (i.e., those on chemotherapies or immunotherapies, or undergoing active surveillance) are required to ascertain the duration, intensity and frequency of exercise that optimises the effects of exercise training on cardiovascular and sexual dysfunctions (and their relationship) in men during and following treatment for prostate cancer.
The Function of Adsorption, Photo-Oxidation, and Humic Acid Using Air Backwashing in Integrated Water Treatment of Multichannel Ceramic MF and PP Particles
Authors: Park Sangwoo , Kim Dongyeop , Park Jin Yong
Published: February 2020

For advanced water treatment, function of microfiltration (MF), adsorption, photo-oxidation, humic acid (HA), and polypropylene (PP) particles on membrane fouling and decay effectiveness were investigated in an integrated water treatment, of multichannel ceramic MF and PP particles, using UV radiation and air backwashing. The synthetic feed was organized with HA and kaolin. The membrane fouling resistance (Rf) of the (MF + PP) system presented the lowermost, and amplified intensely from the (MF + UV) to MF system. The percentages of MF and adsorption by PP particles for turbidity treatment were 87.6% and 3.8%, individually; however, the percentages of MF and adsorption by PP particles for dissolved organic matters (DOM) treatment were 27.9% and 5.0%, respectively. The decay effectiveness of turbidity presented the greatest 95.4% at HA of 10 mg/L; however, that of DOM increased as HA concentration ascended. The ultimate Rf after 180 min procedure showed the maximum at 30 g/L of PP particles concentration, and improved dramatically, as PP particles decreased. Finally, the maximum VT was acquired at 30 and 50 g/L of PP particles, because flux preserved greater throughout the procedure. The decay effectiveness of turbidity and DOM showed the maximal 95.4% and 56.8% at 40 and 50 g/L of PP particles, respectively.
Current Progress in Rheoforming of Wrought Aluminum Alloys: A Review
Authors: Li Gan , Lu Hongxing , Hu Xiaogang , Lin Feng , Li Xinwei , Zhu Qiang
Published: February 2020

Semi-solid processing (SSP), including rheoforming and thixoforming, offers a promising opportunity to manufacture net-shaped parts with complex structure and excellent mechanical properties. Owing to its low cost and short process, rheoforming has been the subject of extensive study over the last two decades. The interest in the rheoforming of wrought aluminum alloys is progressively growing among both the research and industrial communities. This review starts with reviewing the recent efforts and advances on preparation of semi-solid slurry of wrought Al alloys, followed by discussing the correlation between microstructure and performance of these alloys. Finally, special attention is paid in the industrial application and the future trends of rheoforming of wrought aluminum alloys.
Depression of Pyrite in Seawater Flotation by Guar Gum
Authors: Castellón César I. , Piceros Eder C. , Toro Norman , Robles Pedro , López-Valdivieso Alejandro , Jeldres Ricardo I.
Published: February 2020

The application of guar gum for pyrite depression in seawater flotation was assessed through microflotation tests, Focused Beam Reflectance Measurements (FBRM), and Particle Vision Measurements (PVM). Potassium amyl xanthate (PAX) and methyl isobutyl carbinol (MIBC) were used as collector and frother, respectively. Chemical species on the pyrite surface were characterized by Fourier-transform infrared spectroscopy (FTIR) spectroscopy. The microflotation tests were performed at pH 8, which is the pH at the copper sulfide processing plants that operate with seawater. Pyrite flotation recovery was correlated with FBRM and PVM characterization to delineate the pyrite depression mechanisms by the guar gum. The high flotation recovery of pyrite with PAX was significantly lowered by guar gum, indicating that this polysaccharide could be used as an effective depressant in flotation with sea water. FTIR analysis showed that PAX and guar gum co-adsorbed on the pyrite surface, but the highly hydrophilic nature of the guar gum embedded the hydrophobicity due to the PAX. FBRM and PVM revealed that the guar gum promoted the formation of flocs whose size depended on the addition of guar gum and PAX. It is proposed that the highest pyrite depression occurred not only because of the hydrophilicity induced by the guar gum, but also due to the formation of large flocs, which could not be transported by the bubbles to the froth phase. Furthermore, it is shown that an overdose of guar gum hindered the depression effect due to redispersion of the flocs.
Generation and Transport of Dielectric Droplets along Microchannels by Corona Discharge
Authors: Tang Qiang , Zhou Shangru , Hu Ruiheng , Zheng Huai , Pan Junheng , Tang Jau
Published: February 2020

In this paper, a phenomenon of generation and transport of droplets is proposed, which is based on the dielectric liquid electroconvection induced by corona discharge. We placed the dielectric fluid on a conductive/nonconductive substrate, and then it broke apart to become many small droplets that move along the conductive microchannel. The behaviors of dielectric droplets were experimentally observed on different conductive microchannels in details. Spreading speeds and sizes of dielectric droplets were analyzed at different driving voltages and conductive microchannels. This work highlights a simple approach to produce and manipulate dielectric droplets along microchannels.
Electrical Re-Writable Non-Volatile Memory Device Based on PEDOT:PSS Thin Film
Authors: Salaoru Iulia , Pantelidis Christos Christodoulos
Published: February 2020

In this research, we investigate the memory behavior of poly(3,4 ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) cross bar structure memory cells. We demonstrate that Al/PEDOT:PSS/Al cells fabricated elements exhibit a bipolar switching and reproducible behavior via current–voltage, endurance, and retention time tests. We ascribe the physical origin of the bipolar switching to the change of the electrical conductivity of PEDOT:PSS due to electrical field induced dipolar reorientation.
Through-Mask Electrochemical Micromachining with Reciprocating Foamed Cathode
Authors: Zhao Chenhao , Ming Pingmei , Zhang Xinmin , Qin Ge , Shen Jiwen , Yan Liang , Zheng Xingshuai , Cao Jun
Published: February 2020

A through-mask electrochemical micromachining process with a foamed cathode (foamed-cathode through-mask electrochemical micromachining (TMEMM)) has recently been proposed involving micro-scale surface microstructures with a high geometric consistency that are fabricated on the curved-surface workpiece. In this paper, to make the foamed-cathode TMEMM process more cost-efficient in the applications, significant modifications are made to this process and an upgraded version of the foamed-cathode TMEMM process is developed. In this modified process, the sandwich-like unit (including the foamed cathode, mask, and workpiece) is closely assembled by the magnetic field force instead of the conventionally-used mechanical force and is kept moving up-and-down inside the electrolyte, avoiding the use of the traditional pump-driven circulation for the electrode process. Experiments are carried out to evaluate the machining effect of this modified TMEMM for fabricating micro-dimples. The research results verify that this modified TMEMM process can produce highly uniform micro-dimples whose minimum CV (coefficient of variation) values in depth and in diameter are 5.4% and 1.9%, respectively, with smooth surfaces of the minimum Ra being 0.21–0.35 µm. These values are smaller than those previously reported. This results in the positive effects on the mass transfer driven by magnetohydrodynamic convection induced by the magnetic field within the interelectrode and the foamed electrode.
Interferon-γ Possesses Anti-Microbial and Immunomodulatory Activity on a Chlamydia trachomatis Infection Model of Primary Human Synovial Fibroblasts
Authors: Di Pietro Marisa , Filardo Simone , Frasca Federica , Scagnolari Carolina , Manera Martina , Sessa Vincenzo , Antonelli Guido , Sessa Rosa
Published: February 2020

Chlamydia trachomatis, an obligate intracellular pathogen, is the most common cause of bacterial sexually transmitted diseases, and it is potentially responsible for severe chronic sequelae, such as reactive arthritis. To date, details of the mechanisms by which Chlamydiae induce innate antimicrobial pathways in synovial fibroblasts, are not well characterized; therefore, herein, we investigated the effects of interferon (IFN)α, IFNβ, and IFNγ on the infection, and replication phases of the C. trachomatis developmental cycle, as well as on the induction of pattern recognition receptors (PRRs) and IFN-related pathways. To do so, we set up an in vitro chlamydial-infection model of primary human synovial cells treated with IFNs before or after the infection. We then determined the number of chlamydial inclusion forming units and inclusion size, as well as the expression of toll like receptor (TLR)2, TLR3, TLR4, cyclic GMP-AMP synthase (cGAS), stimulator of IFN gene (STING), IRF9, ISG56, and GBP1. The main result of our study is the significant inhibition of C. trachomatis infection and replication in human synovial cells following the treatment with IFNγ, whereas IFN-I proved to be ineffective. Furthermore, IFNγ greatly upregulated all the PRRs and ISGs examined. In conclusion, IFNγ exhibited a potent anti-Chlamydia activity in human synovial cells as well as the ability to induce a strong increase of innate immune pathways.
Molecular Dynamics Simulation on Microstructure and Physicochemical Properties of FexO-SiO2-CaO-MgO-“NiO” Slag in Nickel Matte Smelting under Modulating CaO Content
Authors: Wang Guohua , Cui Yaru , Li Xiaoming , Yang Shufeng , Zhao Junxue , Tang Hongliang , Li Xuteng
Published: February 2020

To improve the conditions of extracting iron from nickel smelting residues, the composition modulating from FexO-SiO2-CaO-MgO-“NiO” slag source for matte smelting using high MgO nickel sulfide concentrate was carried out. Based on the molecular dynamics simulation and experimental characterization, the effect of CaO content in nickel slags on the physicochemical properties, the microstructure evolution, and the feasibility of subsequent iron extraction were analyzed. The results showed that, for nickel smelting slag with 9 wt.% MgO, 13–15 wt.% CaO and Fe/SiO2 ratio of 1.2, the melting temperature of nickel slag was lower than 1200 °C, and the viscosity was lower than 0.22 Pa·s at 1350 °C. The electric conductivity was similar to that of the industrial slag, and the interfacial tension between slag and matte was relatively large, which ensured a good separating characteristic. It not only met the requirements for the slag performances in the existing flash smelting process but also improved conditions for the subsequent iron extraction. Additionally, it could be adapted to the current situation where an increasing MgO content exists in the nickel sulfide concentrate.
Uakitite, VN, a New Mononitride Mineral from Uakit Iron Meteorite (IIAB)
Authors: Sharygin Victor V. , Ripp German S. , Yakovlev Grigoriy A. , Seryotkin Yurii V. , Karmanov Nikolai S. , Izbrodin Ivan A. , Grokhovsky Victor I. , Khromova Elena A.
Published: February 2020

Uakitite was observed in small troilite–daubréelite (±schreibersite) inclusions (up to 100 µm) and in large troilite–daubréelite nodules (up to 1 cm) in Fe-Ni-metal (kamacite) of the Uakit iron meteorite (IIAB), Republic of Buryatia, Russia. Such associations in the Uakit meteorite seemed to form due to high-temperature (>1000 °C) separation of Fe-Cr-rich sulfide liquid from Fe-metal melt. Most inclusions represent alternation of layers of troilite and daubréelite, which may be a result of solid decay of an initial Fe-Cr-sulfide. These inclusions are partially resorbed and mainly located in fissures of the meteorite, which is now filled with magnetite, and rarely other secondary minerals. Phase relations indicate that uakitite is one of the early minerals in these associations. It forms isometric (cubic) crystals (in daubréelite) or rounded grains (in schreibersite). The size of uakitite grains is usually less than 5 μm. It is associated with sulfides (daubréelite, troilite, grokhovskyite), schreibersite and magnetite. Carlsbergite CrN, a more abundant nitride in the Uakit meteorite, was not found in any assemblages with uakitite. Physical and optical properties of uakitite are quite similar to synthetic VN: yellow and transparent phase with metallic luster; Mohs hardness: 9–10; light gray color with a pinky tint in reflected light; density (calc.) = 6.128 g/cm3. Uakitite is structurally related to the osbornite group minerals: carlsbergite CrN and osbornite TiN. Structural data were obtained for three uakitite crystals using the electron backscatter diffraction (EBSD) technique. Fitting of the EBSD patterns for a synthetic VN model (cubic, Fm-3m, a = 4.1328(3) Å; V = 70.588(9) Å3; Z = 4) resulted in the parameter MAD = 0.14–0.37° (best-good fit). Analytical data for uakitite (n = 54, in wt. %) are: V, 71.33; Cr, 5.58; Fe, 1.56; N, 21.41; Ti, below detection limit (<0.005). The empirical formula (V0.91Cr0.07Fe0.02)1.00N1.00 indicates that chromium incorporates in the structure according to the scheme V3+ → Cr3+ (up to 7 mol. % of the carlsbergite end-member).
Rock-Fill Cofferdam Crest Settlement Behavior Analysis Through Geodetic Monitoring Data
Authors: Pal Andrej , Potočnik Drago , Vulić Milivoj
Published: February 2020

Construction of rock-fill dams requires extensive preparatory work. The rationality of construction, ecological aspects, and flood safety must be considered. Potential catastrophic consequences of failure or collapse classify dam structures as high-risk objects which are built according to all safety regulations, and their conditions must be monitored. In this study, we focus on the settlement behavior of a cofferdam crest by analyzing the obtained monitoring data with a non-exponential modified sigmoid function, developed at the Faculty of Natural Sciences and Engineering (FNSE model). Furthermore, monitoring adjustment is introduced, and future settlement is estimated based on verification with actual values.