bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Sumber Daya Manusia Transportasi Penyeberangan dalam Meningkatkan Pelayanan Pariwisata di Danau Toba
Authors: Pardosi Jhonson , Sibarani Robert , Bangun Nur Cahaya , Putra Ilham Mirzaya
Published: December 2021

Sejak tahun 1955 tercatat telah terjadi 7 kali kecelakaan transportasi penyeberangan di Danau Toba yang disebabkan tabrakan hingga kelebihan muatan kapal. Human error dan Miss Management disinyalir menjadi satu diantara penyebab terjadinya peristiwa tersebut. Kecelakaan-kecelakaan tersebut menjadi citra buruk destinasi wisata Danau Toba. Kecelakaan tersebut mengirimkan pesan kepada wisatawan tentang ketidakamanan dan kekhawatiran yang patut diwaspadaiPenelitian ini bertujuan untuk : 1) mengetahui peran Sumber Daya Manusia dalam mendukung Standar Pelayanan Trasportasi Pariwisata di Kabupaten Samosir. Jenis penelitian berdasarkan jenis data dan analisis adalah penelitian kualitatif dengan metode deskriptif. Objek dalam penelitian ini adalah sumber daya manusia transportasi; regulator, penyedia jasa penyeberangan, dan tenaga kerja transportasi danau di Kabupaten Samosir. Metode pengumpulan data dalam penelitian ini ada 3 cara, meliputi observasi, wawancara, dan dokumentasi. Hasil dari penelitian ini adalah: 1) Peran regulator sebagai pembuat kebijakan, stimulator, dan fasilitator. Peran Penyedia Jasa Penyeberangan sebagai pelaksana kebijakan, organisator, dan operator. Peran Awak kapal sebagai pelaksana kebijakan, dan eksekutor, dan 2) Keamanan dan keselamatan transportasi penyeberangan di Danau Toba harus ditingkatkan dengan melibatkan sumber daya manusia transportasi dalam mendukung pelayanan pariwisata
A case of disseminated subcutaneous phaeohyphomycosis caused by Exserohilum rostratum with CARD9 mutation
Authors: Kalantri Mayuri , Khopkar Uday , Shah Avani , Bargir Umair Ahmed , Hule Gouri , Madkaikar Manisha
Published: December 2021

Phaeohypomycosis is a rare cutaneous and subcutaneous fungal infection caused by dematiaceous fungi. They have a widespread global distribution occasionally affecting humans. A 26-year-old woman presented with multiple skin lesions over her face and extremities for last 7 years, unresponsive to systemic amphotericin B and itraconazole. Further investigations revealed CARD9 mutation and phaeohyphomycosis caused by the pigmented fungus Exserohilum rosatratum. Lesions subsequently improved with oral flucytosine and itraconazole.
Preoperative T1 magnetic resonance imaging changes carry a poor postoperative prognosis in cervical myelopathy: A retrospective study of 182 patients
Authors: Shakya Akash , Sharma Ayush , Singh Vijay , Jaiswal Ajay , Marathe Nandan , Garje Vinayak
Published: December 2021

Background:

T2 scans are widely used to determine the prognosis for patients undergoing surgery for cervical myelopathy. In this study, we determined whether T1 MR changes in addition to T2 MR changes could have prognostic importance.

Methods:

This retrospective analysis involved 182 patients undergoing surgery for cervical myelopathy (2017–2020). There were 110 patients in Group 1 (only T2 MR changes) and 72 in Group 2 (both T1 and T2 MR changes). In addition, demographic, visual analog score (VAS), modified Japanese Orthopaedic Association (mJOA) scores, and operative details were recorded at 1 month, 3 months, 6 months, and 1 year postoperatively.

Results:

Notably, VAS scores were comparable at each point in time and were significantly better than the preoperative scores at 1 year postoperatively. Although mJOA scores were comparable at 1 month in both groups, they were better thereafter for Group 1 patients.

Conclusion:

The presence of T1 changes on the preoperative magnetic resonance imaging represented a poor prognostic indicator for the postoperative outcome compared to the presence of T2 changes alone.
Management Strategies for Oral & Maxillofacial Surgery Amid the COVID-19 Pandemic
Authors:   Aga Khan University Hospital, Karachi, Pakistan, Siddiqui Humayun Kaleem , Safdar Jawad , Ghauri Kanza
Published: December 2021

The novel-coronavirus (2019-nCOV) emerged in Wuhan City in December 2019, this resulted in a quick and catastrophic health problem all over the world but our country is slightly less affected by the pandemic. There could be a number of reasons for less numbers of Covid positive cases and lack of awareness and reduced Covid testing capacity and hence less mortality in Pakistan. In order to provide assistance to an ever increasing number of infected patients and, at the same time taking care of urgent maxillofacial conditions. This manuscript gives the reader in a nutshell the overall surgical experience of oral and maxillofacial practice at Aga Khan University Hospital, Karachi, Pakistan in the COVID-19 pandemic and would like to provide a number of recommendations that would assist the scheduling process of surgical management during the COVID-19 pandemic and reduce the risk of infection among healthcare workers and others involved with the service. KEYWORDS: Maxillofacial surgery; Coronavirus; COVID-19; Pandemic
Hyperbaric oxygenation therapy in treatment of traumatic spinal cord injury: a pilot study
Authors: Nekhlopochyn Oleksii S. , Voronov Igor V. , Verbov Vadym V.
Published: December 2021

Spinal cord traumatic injury as resulting persistent movement and sensory disorders is one of the most disabling consequences of traumatic factor impact on the human body. Despite a large number of experimental and clinical studies aimed at developing methods for restoring lost functions, there is no acceptable solution to the problem. One of the promising areas in the treatment and rehabilitation of this category of patients is the use of hyperbaric oxygenation (HBO). Experimental models have shown that HBO has a neuroprotective effect in spinal cord injury, but the results of clinical application of the method are still controversial.
Objective: to determine the effectiveness of HBO in the complex therapy of victims with traumatic spinal cord injury and the feasibility of further study of this area.
Materials and Methods: Study design is a pilot observational retrospective “case – control”. The database of patients with spinal cord injury who were hospitalized at Romodanov Neurosurgery Institute in the period from 2010 to 2020 were used for the analysis. When selecting a control for each clinical case, the following factors were considered: gender, age, circumstances of injury, type of damage to the osteoligamentous apparatus, level of neurological deficit, degree of damage and compression of the spinal cord, time elapsed from the moment of injury to surgery. 28 "case ‒ control" pairs were analyzed. The main criterion for therapy effectiveness was the change in the functional class according to the ASIA scale.
Results. Positive dynamics was registered in 57% of victims, including in the group of patients receiving HBO therapy - in 71%, in the control group - in 43%. HBO therapy in the postoperative period significantly affects the dynamics of regression of neurological disorders (p=0.0295). The odds ratio is 3.333 (95% confidence interval - 1.098‒10.116, p=0.0335). The calculation of the odds ratio, adjusted for additional analyzed factors, showed a more pronounced efficiency - 4.519 (95% confidence interval - 1.279‒15.962, p=0.0192).
Conclusions. The obtained results indicate that usage of HBO as a method of complex therapy for traumatic spinal cord injury is promising for further study in order to determine the effectiveness of the method, the optimal timing of treatment initiation in the postoperative period and its duration.
Surgical treatment of glossopharyngeal nerve schwannomas: Results of two-center study (14 patients included) and literature review
Authors: Sirko Andrii H. , Lisianyi Oleksandr M. , Skobska Оksana Y. , Malyi Rostislav R. , Popovych Iryna O. , Zemskova Oksana V.
Published: December 2021

Objective: This study is aimed to analyze the outcomes of surgical treatment of glossopharyngeal schwannomas based on pre- and postoperative neurological status assessment.
Materials and methods: This paper is a retrospective analysis of examination and surgical treatment of 14 patients who were operated on in two large clinics from 2018 to 2021 inclusive. When analyzing the collected data, gender, age, disease symptoms, tumor size and location, surgical approach, tumor to cranial nerves (CN) ratio, jugular foramen (JF) condition, and tumor removal volume were taken into account. All tumors were divided into groups depending on tumor location relative to the JF. Particular attention was paid to assessing cranial nerves functions. Facial nerve function was assessed as per House-Brackmann Scale (HBS), hearing function as per Gardner-Robertson Scale (GRS).
Results: 3 (21.4%) patients had total tumor removal: 2 patients had type A tumors and one had type B tumor. Subtotal resection took place in 7 (50%) cases. In 4 cases, a tumor was partially removed: 3 patients had type D tumors and one had type B tumor.
3 (21.4%) patients had preoperative FN deficit (HBS Grade II) and mild dysfunction. 5 (35.7%) patients had postoperative facial nerve deficit: HBS ІІ, 2; ІІІ, 1; V, 2.
Preoperative sensorineural type hearing impairment on the affected side was diagnosed in 13 (92.6%) patients. Before surgery, 6 patients had non-serviceable hearing, which remained at the same level after surgery. None of the patients with grade I or II hearing before surgery had any hearing impairment postoperatively. In 2 (14.3%) cases, hearing improved from grade V to grade III after surgery.
6 (42.9%) patients developed new neurological deficit in the caudal group CN. Postoperative deficit of the caudal group CN occurred in type D tumors in 3 patients, type A tumors 2 patients, and type B tumors one patient.
Conclusions: Applying a retrosigmoid approach only makes it possible to achieve total tumor removal in case of type A tumors. To remove other tumor types, it is necessary to select approaches that enable access to the jugular foramen and infratemporal fossa. Intraoperative neurophysiological monitoring is an extremely important tool in glossopharyngeal schwannoma surgery.
The most common postoperative complication is a developed or increased deficit of the caudal CN group, which can lead to persistent impairments in the patients’ quality of life. Preservation of the CN VII and VIII function in most cases is a feasible task and shall be ensured as a standard for this pathology.
Analisis Faktor-Faktor yang Mempengaruhi Kepuasan Pelayanan Pasien diinstalasi Farmasi RSUD Rantauprapat
Authors: Nasution Sri Lestari Ramadhani , Purwanti Dewi , Girsang Ermi
Published: December 2021

Adapun masalah yang ditemukan adalah waktu tunggu pelayanan resep pasien melebihi standar yang ditetapkan pemerintah untuk obat non racikan kurang dari 30 menit dan obat racikan kurang dari 60 menit, yaitu untuk obat non racikan selama 39 menit dan obat racikan selama 60,4 menit. Sedangkan faktor yang mempengaruhi waktu tunggu pelayanan obat antara lain masih adanya kekosongan obat saat pelayanan, masih adanya dokter yang belum berpedoman pada buku daftar dan plafon harga obat, sehingga petugas harus mengkonfirmasi ulang, dan adanya petugas yang belum mengerjakan resep karena masih melakukan kegiatan atau resep lain. Tujuan penelitian adalah untuk mengetahui faktor-faktor yang mempengaruhi kepuasan pelayanan pasien di Instalasi Farmasi RSUD Rantauprapat. Sampel dalam penelitian ini adalah beberapa dari pasien rawat jalan di instalasi farmasi yang berjumlah 35 orang dengan teknik pengambilan sampel menggunakan Purposive Sampling. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh waktu tunggu dengan kepuasan pasien. Terdapat pengaruh informasi dengan kepuasan pasien. Terdapat pengaruh sumber daya manusia dengan kepuasan pasien. Terdapat pengaruh sarana prasarana dengan kepuasan pasien. Terdapat pengaruh kepuasan terhadap peningkatan kinerja pasien. Variabel yang paling dominan dalam penelitian ini adalah variabel X4 yaitu peran informasi.
FEATURES OF RESOURCE POTENTIAL MANAGEMENT OF ENTERPRISE
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Zhygalkevych Zhanna , Yefimova Liubov ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: December 2021

At the present stage of economic development, the efficiency of enterprises is influenced by external and internal factors. The efficiency of the enterprise management process largely depends on the rational management of resources. The problem of improving the efficiency of resource potential is a topical issue, the solution of which is devoted to this article. Resources are defined as opportunities, because they reproduce the potential of enterprises in terms of quantitative and qualitative parameters of production of goods or services. The resource potential of enterprises is a set of all resources of the enterprise that provide the opportunity to obtain the maximum economic effect in a certain period. For effective management of resource potential, an effective system of formation of resource provision of enterprise development should be created, which is able to increase the efficiency of economic activity of the business entity. The article studies the effectiveness of resource management of the enterprise on the example of PJSC «Industrial and Distribution Systems» and provides an assessment of the use of certain components of the resource potential of the enterprise. The main attention is paid to the analysis of efficiency of use of the basic production assets as base of production and economic activity of the enterprise. This will determine the amount of reserve capacity for further development of the enterprise and will contribute to the creation of an effective system for managing itsresource potential. Based on the analysis at this company, a vector for improving the process of resource management is proposed, which requires further research. The results of the study allow domestic enterprises, including PJSC «Industrial and Distribution Systems», to use in practice measures to improve the efficiency of rational management of development resources in order to improve the process of their use.
FINANCIAL COMPONENT OF THE FOREIGN TRADE ACTIVITIES INFRASTRUCTURE OF THE AGRICULTURAL SECTOR SMALL BUSINESS ENTITIES
Authors:   Odessa National Academy of Food Technologies, Bakhchivanzhi Liudmyla , Barbinyagra Oleksandr ,   Odessa National Academy of Food Technologies
Published: December 2021

The article reflects the results of the study of the financial component of the foreign trade infrastructure formation, taking into account the peculiarities of export entrepreneurship of small entities of the agricultural economic sector. The methodological toolkit of the article is built on the basis of a systematic approach using the financial analysis and abstract-logical generalization of research results. It was revealed that agricultural enterprises currently, according to the World Trade Center, have a significant under-traded export potential due to imperfection and insufficient capacity of the infrastructure to support foreign trade, and measures to form and expand the infrastructure of foreign trade require appropriate financial and investment support. The state of funding sources was analyzed and diagnostics of the financial state of the agricultural sector was carried out in the context of the analysis of the dynamics of indicators of the financial state, for which the normative value is not established and the indicators, the assessment of which is carried out in comparison with the normative value. A tendency towards a decrease in the profitability of assets and equity capital, an excess of the growth rate of accounts payable over accounts receivable, current liabilities over current assets, cost over net income from product sales, as well as a downward trend in financial results from operating activities and net profit are revealed. It was found that the financial activities of agricultural enterprises did not allow them to achieve the required level of their own and borrowed resources to finance the development of foreign trade infrastructure. The institutional factors of the internal and external (international) environment of the foreign trade financial infrastructure formation are analyzed. In order to overcome the existing destructive tendencies, it is proposed to search for foreign markets with higher prices for agricultural products with an orientation to markets with a high under-traded export potential. It is proposed to use the terms of cooperation to ensure accessibility to external sources of financing and innovative financial instruments for small and micro-agricultural enterprises, to directly provide trade financing or credit guarantees by the government.
REFORMING THE TAX SYSTEM AS A FACTOR IN ENSURING FINANCIAL SECURITY OF UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Varnalii Zakharii , Kislova Anna ,   Taras Shevchenko National University of Kyiv
Published: December 2021

This article identifies the relevance of proactive state policy aimed at increasing the competitiveness of the Ukrainian economy, improving the indicators of economic and financial resilience and resilience of the national economy to potential threats; The interconnection between the tax system and financial security of the country was disclosed; problems of Ukraine's tax system that pose serious threats to the national security of the state, its economic and financial sovereignty were outlined. It also describes the basic principles of building an effective tax system and variants of their implementation in successful countries. Special attention is paid to the process of formation of the tax system of Ukraine, which has determined the specificity of today's gaps in its financial security. The significant part of the work is devoted to the concrete problems of the tax system of Ukraine: Economic inefficiency and social injustice of the country's taxation, a large part of the shadow sector of the economy and "shadow power", low culture of tax lawmaking and lack of consistent comprehensive reform of the tax system for 30 years of Independence, mainly fiscal nature of taxes, unreasonable, non-refundable, unfair and counterproductive system of tax payments, etc. The article also characterized the way in which the mentioned problems of the tax system essentially worsen the state of national security of the state and described why the tax system of Ukraine requires a thorough, profound, scientifically based and complex reforming. We confirm that this reform is necessary in view of the fact that the social inefficiency of Ukrainian taxation is a strategically dangerous problem for the defense of the country. While it will take a long time to develop a sound integrated inter-sectoral reform, the policy changes outlined in this paper must be pursued in parallel in order to enable the system to function properly in its current state. The study was conducted using mainly general scientific theoretical methods.
EVALUATION OF DEBT FINANCING INSTRUMENTS OF THE BUSINESS ENTITY
Authors:   National Academy of Statistics, Accounting and Auditing, Pylypenko Oleksiy
Published: December 2021

Peculiarities of accounting for transactions in derivative financial instruments are due to the risks inherent in such objects of accounting, in particular in terms of uncertainty about their fair value in the future. Improving the methods and forms of regulation of derivative financial instruments through the mechanisms of accounting methodology determine the need to find opportunities to improve the methodological and organizational principles of accounting in terms of valuation of derivatives, taking into account the practice of IFRS to achieve reliability of financial statements. Difficulties in reconciling UAS with IFRS on the valuation of derivative financial instruments (historical or fair value) are due to the application in regulations of different approaches to the formation of financial statements. It is proved that the use of the historical cost method for valuation of financial instruments is inappropriate, as their contractual nature is manifested in the ability to carry out indefinitely transactions that do not lead to cash settlements, but increase the financial risks of the enterprise. The application of the fair value method for the valuation of derivative financial instruments sets out special requirements for the organization of the valuation process of financial instruments in order to ensure the further choice of sources of financing and financial risk management. The list of elements of the accounting policy which should be provided in the administrative document on the accounting policy of the enterprise which cover methodical and organizational receptions of the account is defined. The classification of financial instruments is defined as the basis for the choice of accounting policy methods. The minimization of potential risks of losses due to the use of incorrect valuation of financial instruments should be facilitated by appropriate verification based on the comparison of valuation results based on independently obtained prices with the results provided as a result of valuation procedures. It is proved that the audit should cover liquid financial instruments, as well as those instruments that do not have market prices, which will facilitate further decisions on the adjustment of valuation models and methods.
LABOR MARKET RESEARCH IN DNIPROPETROVSK REGION
Authors:   Ukrainian National University of Science and Technology, Aloshyna Tetiana
Published: December 2021

The main tendencies and peculiarities of the labor market development of Dnipropetrovsk region are considered in the article. There were collected and analyzed the materials of Ukrainian statistical report and Dnipropetrovsk region reports of Statistics Department. There were analyzed general situation of the labor market in Ukraine and regions. The article includes indicators of the labor force of Ukraine in terms of regions over the past five years, identifies the place of the labor market of Dnipropetrovsk region in the overall structure of the labor market of Ukraine. A comprehensive analysis of the labor force indicators of the Dnipropetrovsk region by the number of employed persons, the gender structure of the employed population and the dynamics of the relevant indicators. The structural changes in the composition of the unemployed population of the region by territorial and sexual affiliation are determined, as well as the changes in the sex and age structure of the unemployed population over the past five years. The conducted research made it possible to assess the structural changes in the region's labor force, which are accompanied by a reduction in the labor force, a decrease in the labor force, and an increase in the unemployed population.
IMPROVING THE LABOR POTENTIAL MANAGEMENT OF THE PHARMACEUTICAL COMPANY AS A FACTOR OF INCREASING ITS COMPETITIVENESS
Authors:   National Pharmaceutical University, Hladkova Olha , Posylkina Olga ,   National Pharmaceutical University
Published: December 2021

The article is devoted to the issues of improving the process of managing the labor potential of a pharmaceutical company (PC) to increase its competitiveness. On the basis of theoretical studies, a definition of the category "labor potential of PC" was given, which should be considered as the synergistic possibilities of its labor resources to provide effective activities and the necessary productivity, which depends on the complexity of social, communication, organizational, economic, material and technical and other capabilities of the enterprise. The requirements for managing the labor potential of PC in terms of quality management in accordance with ISO 9000 and 9004 and the OHSAS system are considered. A process model for managing the labor potential of a pharmaceutical enterprise has been built and critical control points for the quality of labor potential management have been identified. The main processes in the proposed process model include personnel planning, recruitment, recruitment, and adaptation of personnel; organization of work and motivation; development of personnel, certification of personnel, and assessment of the qualities of labor potential. The following are identified as management processes: analysis of the existing labor market, analysis of the educational services market, development of a management strategy and development of labor potential in accordance with the general development strategy of PC, monitoring, and audit of the results and efficiency of labor potential management processes, HR risk management. The supporting processes include the development of business culture and corporate culture, the development of social infrastructure, the development of communication, the development of material, technical and financial support for the personnel management process. The following are identified as critical points of control over the quality of management of labor potential of PC: recruitment and adaptation of personnel; personnel certification and personnel development. It has been established that the certification of personnel is a key stage in assessing their professional qualities. Proceeding from this, the article proposes an algorithm and a program for assessing the qualities of personal characteristics of the labor potential of PC in order to increase its competitiveness.
Probing electrolyte influence on CO2 reduction in aprotic solvents
Authors: Gomes Reginaldo , Birch Chris , Cencer Morgan , Li Chenyang , Son Seoung-Bum , Bloom Ira , Assary Rajeev , Amanchukwu Chibueze
Published: December 2021

Selective CO2 capture and electrochemical conversion is an important tool in the fight against climate change. Industrially, CO2 is captured using a variety of aprotic solvents due to their high CO2 solubility. However, most research efforts on electrochemical CO2 conversion use aqueous media and are plagued by competing hydrogen evolution reaction (HER) from water breakdown. Fortunately, aprotic solvents can circumvent HER; making it important to develop strategies that enable integrated CO2 capture and conversion in an aprotic solvent. However, the influence of ion solvation and solvent selection within nonaqueous electrolytes for efficient and selective CO2 reduction is unclear. In this work, we show that bulk solvation behavior within the nonaqueous electrolyte can control the CO2 reduction reaction and product distribution occurring at the catalyst-electrolyte interface. We study different TBA (tetrabutylammonium) salts in two electrolyte systems with glyme-ethers (e.g., 1,2 dimethoxyethane or DME) and dimethylsulfoxide (DMSO) as a low and high dielectric constant medium, respectively. Using spectroscopic tools, we quantify the fraction of ion pairs that form within the electrolyte and show how ion-pair formation is prevalent in DME electrolytes and is dependent on anion type. More importantly, we show as ion-pair formation decreases within the electrolyte, CO2 current densities increases, and a higher CO Faradaic efficiency is observed at low overpotentials. Meanwhile, in an electrolyte medium where ion-pair fraction does not change with anion type (such as in DMSO), a smaller influence of solvation was observed on CO2 current densities and product distribution. By directly coupling bulk solvation to interfacial reactions and product distribution, we showcase the importance and utility of controlling the reaction microenvironment in tuning electrocatalytic reaction pathways. Insights gained from this work will enable novel electrolyte design for efficient and selective CO2 conversion to desired fuels and chemicals
Production of an energy-storage electrode paper using a pilot-scale paper machine
Authors: Isacsson Patrik , Jain Karishma , Fall Andreas , Chauve Valerie , Hajian Alireza , Granberg Hjalmar , Boiron Lucie , Berggren Magnus , Håkansson Karl , Edberg Jesper , Engquist Isak , Wågberg Lars
Published: December 2021

The global electrification of our society requires an enormous capacity of electrical energy storage. This drives the demand for low-cost and sustainable solutions, where the electrode materials are key components. In the present work, all-organic supercapacitor electrodes have successfully been demonstrated to be produced on a pilot-scale paper machine, thereby showing the feasibility of large-scale production of “paper-based energy storage”. The material concept was based on activated charcoal from pyrolyzed coconut and cationized cellulose pulp, the latter having small amounts of electrostatically adsorbed PEDOT:PSS in order to create a conducting, percolating network. In a pre-trial lab experiment, it was evident that even small addition of 1 wt% PEDOT:PSS gave a large increase in capacitance compared to samples with only activated charcoal. In the pilot trials, the addition of carboxymethylated nanocellulose and/or carbon black was further investigated. The different additions significantly affected several paper properties such as tensile strength and conductivity, but the specific capacitance of the activated charcoal was not affected and was found to be around 65-70 F/g. As more than half of the electrodes mass consisted of pulp fibers, the specific capacitance of the paper electrodes was about 25-30 F/g, which is in the same order of commercial supercapacitor electrodes. The successful production of several 10-meter-long rolls of supercapacitor electrode paper shows the feasibility of producing energy storage devices with papermaking methods, and the work as a whole provides valuable insights on how to further advance bio-based energy storage solutions.
Inverse Molecular Design of Alkoxides and Phenoxides for Aqueous Direct Air Capture of CO2
Authors: Zhang Zisheng , Kummeth Amanda L. , Yang Jenny Y. , Alexandrova Anastassia N.
Published: December 2021

Aqueous direct air capture (DAC) is a key technology toward a carbon negative infrastructure. Developing sorbent molecules with water- and oxygen-tolerance and high CO2 binding capacity is therefore highly desired. In this work, we analyze the CO2 absorption chemistries on amines, alkoxides, and phenoxides with density functional theory (DFT) calculations and search for the optimal sorbent using an inverse molecular design strategy. The alkoxides and phenoxides are found to be more suitable for aqueous DAC than amines thanks to their water-tolerance and capture stoichiometry of 1:1 (2:1 for amines). All three molecular systems are found to obey the same linear scaling relationship (LSR) between pK_(CO_2 ) and pK_a, since both CO2 and proton are bonded to the nucleophilic binding site through a majorly σ bonding orbital. Several high-performance alkoxides are proposed from the computational screening. In contrast, phenoxides have relatively poor correlation between pK_(CO_2 ) and pK_a, showing promise for optimization. We apply genetic algorithm (GA) to search the chemical space of substituted phenoxides for the optimal sorbent. Several promising candidates that break the LSR are discovered. The most promising off-LSR candidate phenoxides feature bulky ortho substituents forcing the CO2 adduct into a perpendicular configuration with respect to the aromatic ring. In this configuration, CO2 utilizes a different molecular orbital for binding than does the proton, and the pK_(CO_2 ) and pK_a are thus decoupled. The pK_(CO_2 )-pK_a trend and off-LSR behaviors are then confirmed by experiments, validating the inverse molecular design framework. This work not only extensively studies the chemistry of the aqueous DAC, but also presents a transferrable computational workflow for understanding and optimization of other functional molecules.
Computational Design of Stapled Peptide Inhibitor against SARS-CoV-2 Receptor Binding Domain
Authors: Choudhury Asha Rani , Maity Atanu , Chakraborty Sayantani , Chakrabarti Rajarshi
Published: December 2021

Since its first detection in 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been the cause of millions of deaths worldwide. Despite the development and administration of different vaccines, the situation is still worrisome as the virus is constantly mutating to produce newer variants some of which are highly infectious. This raises an urgent requirement to understand the infection mechanism and thereby design therapeutic-based treatment for COVID-19. The gateway of the virus to the host cell is mediated by the binding of the Receptor Binding Domain (RBD) of the virus spike protein to the Angiotensin-Converting Enzyme 2 (ACE2) of the human cell. Therefore, the RBD of SARS-CoV-2 can be used as a target to design therapeutics. The α1 helix of ACE2 which forms direct contact with the RBD surface has been used as a template in the current study to design stapled peptide therapeutics. Using computer simulation, the mechanism and thermodynamics of the binding of six stapled peptides with RBD have been estimated. Among these, the one with two lactam stapling agents has shown binding affinity, sufficient to overcome RBD-ACE2 binding. Analyses of the mechanistic detail reveal that a reorganization of amino acids at the RBD-ACE2 interface produces favorable enthalpy of binding whereas conformational restriction of the free peptide reduces the loss in entropy to result in higher binding affinity. The understanding of the relation of the nature of the stapling agent with their binding affinity opens up the avenue to explore stapled peptides as therapeutic against SARS-CoV-2.
Modulating Electronic Properties of Dinitrosoarene Polymers
Authors: Matasović Lujo , Panić Barbara , Bubaš Matej , Vančik Hrvoj , Biljan Ivana , Rončević Igor
Published: December 2021

We present a comprehensive analysis on how the electronic structure and the optical properties of an organic polymer can be modulated, based on the example of the dinitrosobenzene polymer (1). Using a combination of computational and experimental tools, we explore the effects of solid-state packing, backbone torsion, surface adsorption, the conjugation in the aromatic core, and substituents. The band gap (Eg) and optical spectrum of 1 are calculated using both GW-BSE with zero-gap renormalization (ZGR) and hybrid TD-DFT, with the former method predicting a value (2.41 eV) in excellent agreement with our diffuse reflectance spectroscopy measurements (2.39 eV). Using GW-BSE-ZGR, changes occurring upon solidstate packing are separated into a contribution arising from (i) the change in the torsional angle and (ii) the change in the screened Coulombic interaction, which strongly effects the exciton binding energies. Comprehensive hybrid TD-DFT calculations find that the effects of substituents on Eg and on transport properties can mostly be explained through changes in the torsional angle, and predict a linear dependence between it and Eg. Extending the conjugation in the aromatic core is found to enhance transport properties and narrow Eg, identifying future synthetic targets. Atomic force microscopy and spectroscopic ellipsometry are used to study 1 adsorbed to a (111) gold surface (1@Au), with the latter method showing a significant narrowing of the band gap to 0.68 eV, in good agreement with TD-DFT predictions.
Marketing mix strategy determinants and social media in veterinary-based business: experience from Serbia
Authors:   University Business Academy in Novi Sad, Faculty of Contemporary Arts, Belgrade, Serbia, Ilić Milena ,   Information Technology School ITS – Belgrade, Belgrade, Serbia, Gojković Milica ,   NCR Corporation Belgrade, Serbia, Blažić Ksenija ,   Syneos Health Belgrade, Serbia, Radi Ciuperca Karla ,   VetCenter Otopeni, Romania, Simion Violeta-Elena ,   Faculty of Veterinary Medicine, Spiru Haret UniversityBucharest, Romania
Published: December 2021

The paper is dedicated to testing the entrepreneurial idea of founding a service micro company in the field of veterinary medicine - Animal Care. The starting point is the theoretical aspect of marketing mix services observed through the prism of a specific company in the field of agribusiness. For the needs of the research, secondary sources were used and a survey was conducted which gave the results of the influence of the elements of marketing mix services on marketing communication towards the users of the company Animal Care. It was determined that the effects of promotion, especially in the field of digital marketing, directly affect the increase in sales of products and services, and thus the satisfaction of consumers & users in veterinary services. The results of the research provided answers to research questions and helped the entrepreneur to understand that selected elements of the marketing mix help in the promotion of products and services of Animal Care companies. Respondents showed interest in using the services of the Animal Care company with the help of the Animal Care android application and website as a selected distribution channel, but also for the promotion of new services and offers of the company
ANALISIS GEJALA BAHASA PADA SURAT DINAS DI KANTOR DESA PENGKOL NGUTER SUKOHARJO [Analysis of Language Symptoms in Service Letters in The Village Office Of Pengkol Nguter Sukoharjo]
Authors: Anggraini Desy , Nasucha Yakub
Published: December 2021

Official letters are one of the written languages used in government agencies or organizations. Official letters sometimes do not pay attention to the correct grammatical rules. This study aims to analyze the language phenomena in official letters of the Pengkol Village Office, Nguter, Sukoharjo. This research is qualitative research using descriptive method. The data used in this study are language phenomena contained in the official lettesr of the Pengkol Village Office. The source of data in this research is an official letter made by employees of the Pengkol Village Office. The data collection technique used is the literature review, listening, and note-taking. The data analysis technique used is qualitative technique. The results of this study indicate that the language phenomena found in official letters of the Pengkol Village Head Office are interference, hypercorrection, pleonasm, and contamination. Out of the four forms of those phenomena, the most frequesnt is hypercorrection, while the least is interference. Surat dinas merupakan salah satu bahasa tulis yang digunakan dalam instansi pemerintah atau organisasi. Dalam surat dinas terkdang tidak memperhatikan penulisan yang sesuai dengan kaidah penggunaan bahasa yang benar. Penelitian ini bertujuan untuk menganalisis gejala bahasa yang ada dalam penulisan surat dinas di Kantor Desa Pengkol, Nguter, Sukoharjo. Penelitian ini termasuk jenis penelitian kualitatif dengan menggunakan metode deskriptif. Data yang digunakan dalam penelitian ini yaitu gejala bahasa yang terdapat dalam surat dinas Kantor Desa Pengkol. Adapun sumber data dalam penenlitian ini adalah surat dinas yang dibuat oleh pegawai Kantor Desa Pengkol.  Teknik pengumpulan data yang digunakan yaitu teknik pustaka, simak, dan catat. Adapun teknik analisis data yang digunakan yaitu teknik kualitatif. Hasil penelitian ini menunjukkan bahwa gejala bahasa yang ditemukan dalam penulisan surat dinas Kantor Kepala Desa Pengkol, yaitu gejala interferensi, gejala hiperkorek, pleonasme, dan kontaminasi. Dari keempat bentuk gejala tersebut, gejala bahasa yang sering mucul adalah bentuk gejala bahasa hiperkorek, sedangkan yang paling sedikit yaitu bentuk gejala bahasa interferensi.
Patrimonialización de Áreas Naturales - prácticas vulnerables en las Reservas de Biosfera de Argentina y Brasil
Authors: Martins Fonseca Virginia , Bustos Cara Roberto Nicolas
Published: December 2021

Fue adoptado como el objetivo de investigación comprender cómo se configura el reconocimiento de los territorios naturales bajo la perspectiva del patrimonio internacional, desde la contextualización de presupuestos teóricos y documentales. Se identificaron tres influencias relevantes como resultados, en términos de perspectivas teóricas, a saber: “orden ambiental internacional”; “patrimonialización del territorio” y; “valoración turística”. Como presupuestos documentales, se contextualizaron las realidades tanto de la Reserva de la Biosfera Norpatagónica Andina (Argentina) como de la Reserva de la Biosfera Serra do Espinhaço (Brasil), lo que mostró que tales procesos de internacionalización de áreas naturales protegidas son muy fragilizados en cuanto al real involucramiento de la población local para favorecer el debate legítimo sobre cuáles serían las posibilidades de integración del “hombre en la naturaleza” como efectiva estrategia de una ecología política.
El habitar en el centro histórico de Camagüey, Cuba
Authors: Falls Valdivieso Dianelis , Chaos Yeras Mabel Teresa
Published: December 2021

La arquitectura del Movimiento Moderno a nivel internacional y en el contexto regional de América Latina, constituye un referente para el estudio de las soluciones espaciales y el papel jugado por la envolvente en la relación interior-exterior de cualquier arquitectura local. En el presente artículo se ofrecen los resultados del estudio de una muestra intencional de edificios de apartamentos del Movimiento Moderno en el centro histórico de Camagüey, que brindan soluciones propias a partir de la asimilación de los postulados del Movimiento Moderno internacional. Se exponen las características espaciales de los edificios de apartamentos del Movimiento Moderno en el centro histórico de Camagüey, que los definen, y se reflexiona sobre la percepción y valoración subjetiva de sus habitantes.
Patrimônio, paisagem e simbolismos no centro histórico de Aquiraz, Ceará, Brasil
Authors: Vasconcelos Yan de Abreu Gomes
Published: December 2021

A pesquisa objetivou analisar a dimensão subjetiva estabelecida a partir dos diversos olhares dos moradores da cidade de Aquiraz, Ceará, sobre sua paisagem patrimonial. Metodologicamente, optamos pela prática da observação participante e realização de entrevistas de caráter semiestruturado, pois a mesma ofereceu melhor embasamento na leitura dos significados presentes na paisagem simbólica da área de estudo. Após a realização dos diálogos com os residentes de Aquiraz e a análise de suas falas, identificamos que os aquirazenses nutrem e mantém pelo núcleo inicial de sua cidade um sentimento de vínculo com o lugar. Os residentes entendem que aquele espaço simboliza o início de sua cultura e de sua identidade, um elo que os liga pela nostalgia, memória e pertencimento ao lugar.
PREFERENCES OF CENTRAL EUROPEAN CONSUMERS IN CIRCULAR ECONOMY
Authors: Olah Judit , Tiron Tudor Adriana , Pashkus Vadim , Alpatov Genady
Published: December 2021

Research background: Consumers’ interest in environmental responsibility, sustainable consumption, and the circular economy is significantly increasing in all aspects of their lives. Clothing and fashion are clearly among these aspects. The fashion industry is one of the most resource-intensive and environmentally polluting industries. Circularity has been offered as a solution to this issue; however, the change must be in the attitudes of all concerned (Musova et al., 2021b). Businesses must react to this requirement for sustainable fashion, which is the reason that new circular concepts have been raised. Different generations prefer different models of circularity. Purpose of the article: The purpose of the current study is to detect the existence of dependency between generation and the fashion industry’s circular models, and to identify consumers’ specific preferences. Methods: The original consumer survey was undertaken by the authors in 2021, and involved 513 Slovak and 974 Czech consumers, who responded on their preferences in the circular economy. Pearson’s chi-square test of independence was used to confirm the dependence between consumers’ generation and the circular concept. The significant medium dependence of the nominal variables was confirmed by Pearson’s contingency coefficient, C, and Cramer's V. The relationships between the generation categories of Central European consumers and the categories of the new circular models in the fashion industry were established through correspondence analysis. Findings & Value added: The findings of the study suggest that Baby boomers single out capsule wardrobes, Generation X prefers patchwork and slow fashion, while Millennials prioritise GOTS and SWAP. Finally, Generation Z favours leasing jeans, upcycling, and renting clothes.
Engagement with Diabetes Retinal Screening: An analysis of secondary data from the Pacific Eye Institute in Suva
Authors: Cronin-Lampe Joshua , Cavadino Alana , Ansari Harris , Fa'alau Faufiva , Mccool Judith
Published: December 2021

Abstract

Objectives: Diabetic retinopathy (DR) is one of the primary causes of preventable vision loss and blindness. Diabetic retinopathy screening (DRS) is essential to detect microvascular damage to the retina; it can be performed in primary care or specialist eye health clinics. The system of referral, screening, and treatment relies on an organized primary care referral pathway, accessible services, and at least a basic level of health literacy among those living with or under threat of developing Diabetes Mellitus (DM).

 

Methods: Routinely collected patient data from the Pacific Eye Institute (PEI) in Fiji was analyzed to describe a) clinical and demographic DR patient characteristics and b) characteristics of patients demonstrating higher clinic engagement (using multiple logistic regression).

 

Results: Of 9287 patients who first attended the PEI for DRS between 2012 and 2017, 22% presented with sight-threatening diabetic retinopathy (STDR) in at least one eye. The average duration of DM was 3 years; self-reported glycaemic control was poor. Indo-Fijian or other ethnicity (both vs iTaukei, OR=2.30, 95%CI 1.96-2.70 and OR=2.18, 95% CI 1.63-2.92, respectively; p<0.001), high blood sugar (OR 1.39, 95%CI 1.10-1.75, p=0.006), longer duration of disease (OR=1.21, 95%CI 1.02-1.43, p=0.027), peripheral neuropathy (OR=1.43, 95%CI 1.24-1.65, p<0.001) and STDR (OR=3.30, 95%CI 2.78-3.92, p<0.001) were associated with greater odds of higher clinic engagement. Male gender (Odds Ratio (OR)=0.83, 95% Confidence Interval (CI) 0.72-0.95, p=0.006), younger or older age (both vs 40-70 years; <40 years, OR=0.48, 95%CI 0.37-0.63, ?70 years OR=0.61, 95%CI 0.48-0.76, p<0.001), year of first clinic visit (2013 vs 2012 OR=0.58, 95%CI 0.50-0.69, p<0.001; 2014 vs 2012 OR=0.36, 95%CI 0.30-0.43, p<0.001) and moderate visual impairment (OR=0.67 95%CI 0.56-0.80, p<0.001) were associated with lower odds of high clinic engagement.

 

Conclusion: Our results identify patient groups that may be more vulnerable to lower engagement with eye health services. Increasing engagement may help reduce delays in screening and treatment. Given the projected continued rise in DM in the Pacific region, investing in robust electronic data systems that collect and connect public health and clinical data is imperative. Health literacy is important for the prevention of DM, timely DM diagnosis, and screening for complications such as DR.
Phonetic Segmentation using a Wavelet-based Speech Cepstral Features and Sparse Representation Classifier
Authors: Al-Hassani Ihsan , Al-Dakkak Oumayma , Assami Abdlnaser
Published: December 2021

Speech segmentation is the process of dividing speech signal into distinct acoustic blocks that could be words, syllables or phonemes. Phonetic segmentation is about finding the exact boundaries for the different phonemes that composes a specific speech signal. This problem is crucial for many applications, i.e. automatic speech recognition (ASR). In this paper we propose a new model-based text independent phonetic segmentation method based on wavelet packet speech parametrization features and using the sparse representation classifier (SRC). Experiments were performed on two datasets, the first is an English one derived from TIMIT corpus, while the second is an Arabic one derived from the Arabic speech corpus. Results showed that the proposed wavelet packet de composition features outperform the MFCC features in speech segmentation task, in terms of both F1-score and R-measure on both datasets. Results also indicate that the SRC gives higher hit rate than the famous k-Nearest Neighbors (k-NN) classifier on TIMIT dataset.