bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Diborane‐Mediated Deoxygenation of o‐Nitrostyrenes to Form Indoles.
Authors: Yang Kai , Zhou Fei , Kuang Zhijie , Gao Guoliang , Driver Tom G. , Song Qiuling
Published: December 2016

A mild, reductive cyclization of ortho‐nitrostyrenes affords indoles via in situ generated nitroso arenes.
ChemInform Abstract: An Atom‐Economic Approach for Vinylation of Indoles and Phenols Using Calcium Carbide as Acetylene Surrogate.
Authors: Rattanangkool Eakkaphon , Vilaivan Tirayut , Sukwattanasinitt Mongkol , Wacharasindhu Sumrit
Published: December 2016

The catalyst‐free method tolerates variously functionalized indoles and phenols.
ChemInform Abstract: Exploiting the Distal Reactivity of Indolyl Methylenemalononitriles: An Asymmetric Organocatalyzed [4 + 2] Cycloaddition with Enals Enables the Assembly of Elusive Dihydrocarbazoles.
Authors: Rassu Gloria , Curti Claudio , Zambrano Vincenzo , Pinna Luigi , Brindani Nicoletta , Pelosi Giorgio , Zanardi Franca
Published: December 2016

Previously elusive 2,9‐dihydro‐1H‐carbazoles become accessible by a novel enantioselective catalytic [4 + 2] eliminative cycloaddition of indolyl methylenemalononitriles with various cinnamaldehydes.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Dearomatization of Indoles via Decarboxylative Alkynyl Termination
Authors: Chen Si , Wu Xin‐Xing , Wang Jia , Hao Xin‐Hua , Xia Yu , Shen Yi , Jing Huanwang , Liang Yong‐Min
Published: December 2016

leading to tetracyclic indoline derivatives
ChemInform Abstract: Bifunctional‐Phosphine‐Catalyzed Sequential Annulations of Allenoates and Ketimines: Construction of Functionalized Poly‐Heterocycle Rings.
Authors: Li Erqing , Jin Hongxing , Jia Penghao , Dong Xuelin , Huang You
Published: December 2016

A highly stereoselective sequential annulation reaction between γ‐substituted allenoates and ketimines is reported.
ChemInform Abstract: Organophosphorus‐Mediated N—N Bond Formation: Facile Access to 3‐Amino‐2H‐indazoles.
Authors: Bel Abed Hassen , Schoene Jens , Christmann Mathias , Nazare Marc
Published: December 2016

Reductive cyclization of 2‐nitro‐benzamidines (I) and (III) affords title compounds (II) and (IV), resp., in moderate to high yields.
ChemInform Abstract: New Imidazolidineiminothione Derivatives: Synthesis, Spectral Characterization and Evaluation of Antitumor, Antiviral, Antibacterial and Antifungal Activities.
Authors: Moussa Ziad , El‐Sharief Marwa A.M.Sh. , Abbas Samir Y.
Published: December 2016

Most of the synthesized compounds (III) show antitumor, antiviral, antibacterial, and antifungal activities.
ChemInform Abstract: Synthesis of Optically Active Trifluoromethyl‐Substituted 2,3‐Dihydroimidazo[2,1‐b]oxazoles.
Authors: Mloston Grzegorz , Wroblewska Aneta , Heimgartner Heinz
Published: December 2016

An intramolecular cyclization of enantiopure N(1)‐(2‐hydroxylpropyl)imidazole N‐oxides, prepared by cyclocondensation of hydroxyethanols, formaldehyde, and α‐ketoximes in the presence of acetic anhydride provides trifluoromethylated 2,3‐dihydroimidazo[2,1‐b]oxazoles with retention of stereochemistry.
ChemInform Abstract: Oxidative Rearrangement Strategy for Synthesis of 2,4,5‐Trisubstituted Oxazoles Utilizing Hypervalent Iodine Reagent.
Authors: Liu Qing , Zhang Xiaohui , He Yang , Hussain Muhammad Ijaz , Hu Wen , Xiong Yan , Zhu Xiangming
Published: December 2016

Trisubstituted oxazoles (II) are directly synthesized from 3‐hydroxybut‐2‐enimidates (I) through oxidative rearrangement strategy using diacetoxyiodobenzene as oxidizing agent under mild conditions.
ChemInform Abstract: Highly Enantio‐ and Diastereoselective [4 + 2] Cycloaddition of 5H‐Oxazol‐4‐ones with N‐Maleimides.
Authors: Qiu Shuai , Lee Richmond , Zhu Bo , Coote Michelle L. , Zhao Xiaowei , Jiang Zhiyong
Published: December 2016

employing Takemoto`s chiral tertiary amine‐thiourea as the catalyst
ChemInform Abstract: Insights into the Pummerer Synthesis of Oxazolines.
Authors: Becerra‐Cely Laura , Rueda‐Espinosa Juan , Ojeda‐Porras Andrea , Gamba‐Sanchez Diego
Published: December 2016

A simple method to access unnatural 2‐substituted 5‐thio oxazolines (II) from sulfoxides (I) is described.
ChemInform Abstract: Novel Synthesis of Tryptamine Derived 4‐Hydroxy‐4‐arylthiazolidine‐2‐thiones and 4‐Arylthiazole‐2(3H)‐thiones by Multicomponent Reactions.
Authors: Devi Nepram Sushuma , Singh Sarangthem Joychandra , Mahiya Kuldeep , Singh Okram Mukherjee , Choi Hojune , Lee Sang‐Gyeong
Published: December 2016

The operationally simple reaction between tryptamine, carbon disulfide, and phenacyl bromide delivers the title products in high yields.
ChemInform Abstract: Convenient Sulfonylation of Benzotriazoles with the in situ‐Generated Sulfonyl Bromides.
Authors: Wu Sixue , Zhang Yikun , Yan Jie
Published: December 2016

Advantages of the new method are mild reaction conditions, simple procedure, and good yields.
ChemInform Abstract: A Synthetic Pathway to Substituted Benzofuroxans Through the Intermediacy of Sulfonates: The Case Example of Fluoro‐Nitrobenzofuroxans.
Authors: Jovene Cyril , Marrot Jerome , Jasmin Jean‐Philippe , Chugunova Elena , Goumont Regis
Published: December 2016

The syntheses of 4‐fluoro‐6‐nitrobenzofuroxan and 6‐fluoro‐4‐nitrobenzofuroxan are achieved from a sulfonate intermediate possessing an electron‐donating group that facilitates the key nitration step.
ChemInform Abstract: A Novel Domino Approach for Synthesis of Indolyl Tetrahydropyrano[4,3‐c]pyrazole Derivatives as Anticancer Agents.
Authors: Wang Fu‐Qiang , Yang Hui , He Bin , Jia Yong‐Kang , Meng Shi‐Yao , Zhang Chao , Liu Hong‐Min , Liu Feng‐Wu
Published: December 2016

A series of indolyl substituted 1,4,6,7‐tetrahydropyrano[4,3‐c]pyrazole derivatives is synthesized via a domino method based on 1,4:6,7‐dianhydrofructose.
ChemInform Abstract: Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa‐Pictet—Spengler Reaction.
Authors: Das Sayantani , Liu Luping , Zheng Yiying , Alachraf M. Wasim , Thiel Walter , De Chandra Kanta , List Benjamin
Published: December 2016

Using chiral nitrated iminodiphosphoric acid‐derived catalyst BPI, title reaction between m‐hydroxyphenylethanols and aldehydes give the 6‐hydroxy‐3,4‐dihydrobenzo[c]pyrans in high yields and excellent enantioselectivities.
ChemInform Abstract: A Simple Efficient Procedure for the Synthesis of Benzopyrano[2,3‐c]pyrazoles.
Authors: Turki H. , Kamoun M. , Lahiani S. , El Gharbi R.
Published: December 2016

10 Title compounds of type (III) and 18 title compounds of type (VI) or (VIII) are prepared.
ChemInform Abstract: Highly Selective and Modular Synthesis of 3‐Aryl‐4‐(arylethynyl)‐2H‐chromen‐2‐ones from 2‐Iodoaryl 2‐Arylacetates Through a Carbonylative Sonogashira Coupling‐Intramolecular Aldol Cascade Reaction.
Authors: Chandrasekhar Attoor , Ramkumar Venkatachalam , Sankararaman Sethuraman
Published: December 2016

A modular method for the synthesis of the title chromenones is developed based on a carbonylative Sonogashira coupling‐intramolecular aldol cascade reaction starting from iodoaryl arylacetates.
ChemInform Abstract: Bi(OTf)3‐Catalyzed Addition of Isocyanides to 2H‐Chromene Acetals: An Efficient Pathway for Accessing 2‐Carboxamide‐2H‐chromenes.
Authors: Lyu Longyun , Jin Ming Yu , He Qijie , Xie Han , Bian Zhaoxiang , Wang Jun
Published: December 2016

An efficient Bi(OTf)3‐catalyzed addition reaction for accessing 2H‐chromene‐2‐carboxamide derivatives is reported.
ChemInform Abstract: KH2PO4 Promoted Practical and Environmentally Friendly Preparation of Coumarin‐3‐carboxylic Acids under Solvent‐Free Condition.
Authors: Lv Chengwei , Gao Shuangqiu , Xiao Di , Yang Ying , Wei Xiaoyue , Sun Sai , Lang Jian
Published: December 2016

A green Knoevenagel‐intramolecular cyclization cascade reaction of Meldrum′s acid with ortho‐hydroxybenzaldehydes affords 3‐coumarincarboxylic acids in good to high yields.
ChemInform Abstract: A Mixed Ligand Approach for the Asymmetric Hydrogenation of 2‐Substituted Pyridinium Salts.
Authors: Renom‐Carrasco Marc , Gajewski Piotr , Pignataro Luca , de Vries Johannes G. , Piarulli Umberto , Gennari Cesare , Lefort Laurent
Published: December 2016

The title reaction gives 2‐substituted piperidines with full conversion and good enantioselectivity using iridium as catalyst and a mixed ligand of a chiral monodentate phosphoramidite and an achiral phosphine.
ChemInform Abstract: The First Solvent‐Free Synthesis of Privileged γ‐ and δ‐Lactams via the Castagnoli—Cushman Reaction.
Authors: Lepikhina Anastasia , Bakulina Olga , Dar'in Dmitry , Krasavin Mikhail
Published: December 2016

36 examples
ChemInform Abstract: A Green, Solvent‐Free One‐Pot Synthesis of Disubstituted Quinolines via A3‐Coupling Using 1 mol% FeCl3.
Authors: Jeena Vineet , Naidoo Shivani
Published: December 2016

A three‐component coupling reaction of anilines with aldehydes and terminal alkynes affords quinolines in moderate to good yields under solvent‐free, microwave irradiation conditions.
ChemInform Abstract: Experimental and Theoretical Observations on the Intramolecular Nucleophilic Addition of α‐Amino Carbanions to Arynes: Synthesis of 1‐Aryl‐1,2,3,4‐tetrahydroisoquinolines.
Authors: Kaur Manjot , Sharma Esha , Singh Amritpal , Singh Paramjit , Singh Kamal Nain
Published: December 2016

A new method involving an intramolecular nucleophilic addition of α‐amino carbanions to in‐situ‐generated arynes in N‐Boc‐protected amine substrates is presented for the synthesis of aryltetrahydroisoquinolines.
ChemInform Abstract: Synthesis of Isoquinolinium via Rhodium(III)‐Catalyzed Oxidative Annulation Between Aldimines and Alkynes.
Authors: Dong Lin , Su Fu , Wang Cheng‐Qi , Zhang Wei , Lin Hui
Published: December 2016

A cyclization of aldehyde imines with alkynes yields isoquinolinium triflates efficiently.
ChemInform Abstract: Copper(II) Trifluoromethanesulfonate Catalyzed Hydroamination Cyclization—Dimerization Cascade Reaction of Homopropargylic Amines for the Construction of Complex Fused Nitrogen‐Containing Tetracycles.
Authors: Liu Lingyan , Wang Chan , Liu Qiangqiang , Kong Yuanfang , Chang Weixing , Li Jing
Published: December 2016

In the case of N,4‐bisarylhomopropargylamines, the reaction proceeds with high diastereoselectivity affording octahydro‐dipyrroloquinolines.
ChemInform Abstract: Efficient Three‐Component Synthesis of Diversely Substituted Tetrahydro‐1H‐cyclopenta[c]quinolines.
Authors: Nino Patricia , Caba Marta , Aguilar Nuria , Terricabras Emma , Albericio Fernando , Fernandez Joan‐Carles
Published: December 2016

The title compounds are prepared by Parov reaction of cyclopentadiene, anilines, and benzaldehydes.
ChemInform Abstract: Regioselective Synthesis of Functionalized [1,6]‐Naphthyridines by KF/Basic Alumina as a Recyclable Catalyst and a Brief Study of Their Photophysical Properties.
Authors: Nandi Sibaji , Islam Mullah Muhaiminul , Saha Mithu , Mitra Sivaprasad , Khatua Snehadrinarayan , Pal Amarta Kumar
Published: December 2016

An efficient, regioselective synthesis of functionalized naphthyridines (IV) (16 examples) via a KF‐Al2O3 catalyzed multicomponent reaction under solvent‐free conditions is developed.
ChemInform Abstract: Selective Synthesis of New Tetracyclic Coumarin‐Fused Pyrazolo[3,4‐b]pyridines and Pyrazolo[3,4‐b]pyridin‐6(7H)‐ones.
Authors: Liu Meilin , Yin Guodong , Zhu Can , Yao Chaochao
Published: December 2016

Depending on the reaction conditions, the three‐component reaction of (I), (III), and an aldehyde affords three different compounds, i.e.
ChemInform Abstract: Fluoride‐Assisted Synthesis of 1,4,5,6‐Tetrahydropyridazines via [4 + 2] Cyclodimerization of in situ‐Generated Azoalkenes Followed by a C—N Bond Cleavage.
Authors: Shelke Anil M. , Suryavanshi Gurunath
Published: December 2016

A series of 1,4,5,6‐tetrahydropyridazines (II) is prepared by homo‐cyclodimerization of α‐halo acylhydrazones (I) in the presence of K2CO3 and CsF (16 examples, however, the halogen in starting α‐halo acylhydrazones is specified only for 3 examples).
ChemInform Abstract: Highly Fluorescent 1,2‐Dihydropyrimido[1,6‐α]indole: An Efficient Metal Free Synthesis and Photophysical Study.
Authors: Das Tapas , Kayet Anirban , Mishra Ruchika , Singh Vinod K.
Published: December 2016

Title compounds (III) are formed via a base catalyzed aldol condensation of indole‐carbaldehydes (I) and arylideneglycinates (II) followed by an intramolecular Mannich‐type reaction.
ChemInform Abstract: One‐Pot Synthesis of Novel 2,8‐Dithioxopyrano[2,3‐d:6,5‐d′]dipyrimidine‐4,6(1H)‐dione Catalyzed by p‐Toluenesulfonic Acid.
Authors: Mahmoodi N. O. , Sharifzadeh B. , Mamaghani M. , Tabatabaeian K. , Shoja S.
Published: December 2016

Title compounds (III) are prepared by TosOH‐catalyzed reaction of aromatic aldehydes with (substituted) thiobarbituric acid.
ChemInform Abstract: Heck Reaction as Key Step in the Synthesis of Hydrogenated 2‐Benzazepin‐1‐ones.
Authors: Quick Matthias P. , Wuensch Bernhard
Published: December 2016

Using 2‐iodobenzoic acid as common starting material, two 2‐benzazepin‐1‐one derivatives (VIII) and (XII) are prepared.
ChemInform Abstract: Iron‐Catalyzed Hydroboration: Unlocking Reactivity Through Ligand Modulation.
Authors: Espinal‐Viguri Maialen , Woof Callum R. , Webster Ruth L.
Published: December 2016

A new catalytic system without the requirement of external reducing agents or activators is developed which is applied to the hydroboration of a broad range of alkenes, including terminal alkyl and styrene derivatives, internal alkenes and dialkenes.
ChemInform Abstract: Lewis Acid Catalysis: Catalytic Hydroboration of Alkynes Initiated by Piers′ Borane.
Authors: Fleige Mirco , Moebus Juri , vom Stein Thorsten , Glorius Frank , Stephan Douglas W.
Published: December 2016

Terminal and internal alkynes are efficiently hydroborated to (E)‐alkenyl pinacol boronic esters with excellent yields and selectivities using a Lewis acid catalyst.
ChemInform Abstract: One‐Pot Synthesis of New Highly Substituted Allylic Phosphorodiamidates.
Authors: Bahri Leila , Barhoumi‐Slimi T. , Mallek R. , Sanhoury M. A. K. , Crousse B. , Ben Dhia M. T.
Published: December 2016

The title phosphorodiamidates are obtained in mixtures of Z and E isomers by phosphorylation of the corresponding alcohols followed by aminolysis.
ChemInform Abstract: Ring Annulation versus Alkylation of Pyrrole with α‐Phosphoryl‐α,β‐unsaturated Ketones.
Authors: Tasgin Dilek Isik , Unaleroglu Canan
Published: December 2016

A facile and convenient route for the synthesis of (het)aryl and phosphoryl substituted pyrrolizines through Sc(OTf)3 catalyzed reaction of α‐phosphoryl‐α,β‐unsaturated ketones with pyrrole is developed.
ChemInform Abstract: Metal‐Free Arylation to Access Distinct Anthracenylphosphonates and Anticancer Activities for These and Allied Phosphonates.
Authors: Baig M. Zubair K. , Pallikonda Gangaram , Trivedi Prakruti , Tulichala R. N. Prasad , Ghosh Balaram , Chakravarty Manab
Published: December 2016

Compound (IIId) shows promising anti‐cancer activity.
ChemInform Abstract: Regioselective, Solvent‐ and Metal‐Free Chalcogenation of Imidazo[1,2‐a]pyridines by Employing I2/DMSO as the Catalytic Oxidation System.
Authors: Rafique Jamal , Saba Sumbal , Rosario Alisson R. , Braga Antonio L.
Published: December 2016

Various diaryl or dialkyl diselenides or disulfides are used for the regioselective C‐3 chalcogenation of imidazo[1,2‐a]pyridines.
ChemInform Abstract: Combretins A and B, New Cycloartane‐Type Triterpenes from Combretum fragrans.
Authors: Dawe Amadou , Kapche Gilbert Deccaux Wabo Fotso , Bankeu Jean Jules Kezetas , Fawai Yakai , Ali Muhammad Shaiq , Ngadjui Bonaventure Tchaleu
Published: December 2016

isolation and structure elucidation
ChemInform Abstract: New Highly Oxidized Formamidobisabolene‐Derived Sesquiterpenes from a Hainan Sponge Axinyssa variabilis
Authors: Liu Hai‐Li , Xue Duo‐Qing , Chen Si‐Han , Li Xu‐Wen , Guo Yue‐Wei
Published: December 2016

isolation and structure determination
ChemInform Abstract: Concise Synthesis of Astellatol Core Skeleton.
Authors: Zhao Nan , Xie Shengling , Chen Gui , Xu Jing
Published: December 2016

The highly challenging core skeleton (I) of the sesterterpenoid fungal metabolite astellatol is synthesized in a ten‐step enantioselective synthesis.
ChemInform Abstract: New Labdane Diterpenoids from Croton laui and Their Antiinflammatory Activities.
Authors: Yang Li , Zhang Yu‐Bo , Chen Li‐Feng , Chen Neng‐Hua , Wu Zhong‐Nan , Jiang Si‐Qi , Jiang Lin , Li Guo‐Qiang , Li Yao‐Lan , Wang Guo‐Cai
Published: December 2016

Nine new title products are isolated, namely compound (I—IV) and diastereomers thereof, some of which show interesting anti‐inflammatory activities.
ChemInform Abstract: New Sterol Derivatives from the Marine Sponge Xestospongia sp.
Authors: Cheng Zhongbin , Liu Dong , de Voogd Nicole J. , Proksch Peter , Lin Wenhan
Published: December 2016

A variety of sterol derivatives including eight new sterols, i.e.
ChemInform Abstract: Fmoc‐OASUD: A New Reagent for the Preparation of Fmoc‐Amino Acids Free from Impurities Resulting from Lossen Rearrangement.
Authors: Rao B. Leela Maheswara , Nowshuddin Shaik , Jha Anjali , Divi Murali K. , Rao M. N. A.
Published: December 2016

The novel reagent (II) reacts with amino acids under mild conditions to give Fmoc‐protected amino acids in high yields and purity.
ChemInform Abstract: A Mild Method for Regioselective De‐O‐methylation of Saccharides by Co2(CO)8/Et3SiH/CO System.
Authors: Zhao Yue‐tao , Huang Lu‐bai , Li Qing , Li Zhong‐jun
Published: December 2016

This de‐O‐methylation method shows regioselectivity in different protected monosaccharides.
ChemInform Abstract: Lyciumaside and Lyciumate: A New Diacylglycoside and Sesquiterpene Lactone from Lycium shawii.
Authors: Rehman Najeeb Ur , Hussain Hidayat , Al‐Riyami Samia Ahmed , Csuk Rene , Khiat Mohammed , Abbas Ghulam , Al‐Rawahi Ahmed , Green Ivan R. , Ahmed Ishtiaq , Al‐Harrasi Ahmed
Published: December 2016

Preliminary evaluations demonstrated that lyciumaside (I) possesses strong antioxidant activity while it is inactive in α‐glucosidase and urease enzymes assays.
ChemInform Abstract: New Phenolic Compounds from the Roots of Lentil (Lens culinaris).
Authors: Zuchowski Jerzy , Pecio Lukasz , Reszczynska Emilia , Stochmal Anna
Published: December 2016

isolation, structure determination and DPPH radical scavenging activity
ChemInform Abstract: Isocassiaoccidentalin B, a New C‐Glycosyl Flavone Containing a 3‐Keto Sugar, and Other Constituents from Cassia nomame.
Authors: Syed Ahmed Shah , Akram Muhammad , Bae Ok‐Nam , Kim Chul Young
Published: December 2016

isolation, structure elucidation, and free radical scavenging activity
ChemInform Abstract: Total Synthesis of Actinophenanthroline A via Double Doebner—Miller Reaction.
Authors: Ghosh Suman Kr , Nagarajan Rajagopal
Published: December 2016

The total synthesis of actinophenanthroline A, a marine actinomycete within the family of Streptomycetaceae (strain CNQ‐149) is reported.
ChemInform Abstract: Three New Alkaloids from Myrioneuron faberi.
Authors: Cao Ming‐Ming , Zhang Yu , Huang Sheng‐Dian , Peng Zong‐Gen , Jiang Jian‐Dong , Hao Xiao‐Jiang
Published: December 2016

Structures of secomyrionamide (I), isomyrionine (II) and 12‐oxomyriberine A (III) are elucidated.
ChemInform Abstract: Two New Alkaloids from the Seeds of Cassia alata and Their Bioactivities.
Authors: Wang Jia‐Qiang , Zhu Dong‐Lai , Yang Pei‐Song , Zhang Wei , Shen Xiao‐Feng , Wang Xin‐Lin , Li Chao , Gong Xiao‐Wei , Zheng Xu‐Dong
Published: December 2016

The new benzo[de]quinolinone alkaloids (Ia) and (Ib) are isolated from the seeds of Cassia alata together with four known alkaloids, and their molecular structures are elucidated.
ChemInform Abstract: Application of a Palladium‐Catalyzed C—H Functionalization/Indolization Method to Syntheses of cis‐Trikentrin A and Herbindole B.
Authors: Leal Raul A. , Bischof Caroline , Lee Youjin V. , Sawano Shota , McAtee Christopher C. , Latimer Luke N. , Russ Zachary N. , Dueber John E. , Yu Jin‐Quan , Sarpong Richmond
Published: December 2016

Formal syntheses of racemic cis‐trikentrin A and herbindole B ((I) and (II), resp.) are reported starting from the acetonide of cis‐5,6‐dihydroxy‐endo‐norborn‐2‐ene with Buchwald‐Hartwig amination and novel C(sp3)‐H amination/indole formation as the key steps.
ChemInform Abstract: Strepoxazine A, a New Cytotoxic Phenoxazin from the Marine Sponge‐Derived Bacterium Streptomyces sp. SBT345.
Authors: Cheng Cheng , Othman Eman M. , Fekete Agnes , Krischke Markus , Stopper Helga , Edrada‐Ebel RuAngelie , Mueller Martin J. , Hentschel Ute , Abdelmohsen Usama Ramadan
Published: December 2016

Strepoxazine A (I) exhibits cytotoxic activity against leukemia HL‐60 cells.
ChemInform Abstract: Flavonoids and Biphenylneolignans with Antiinflammatory Activity from the Stems of Millettia griffithii.
Authors: Ye Hao‐Yu , et al.
Published: December 2016

Five new flavonoids, griffinones A—E ((I)—(V)), and a new biphenylneolignan, griffilignan A are isolated together with ten known compounds.
ChemInform Abstract: Three New Derivatives and Others Constituents from the Roots and Twigs of Trilepisium madagascariense DC.
Authors: Ango Yves P. , Kapche Gilbert D. W. F. , Kuete Victor , Mapitse Renameditswe , Yeboah Samuel O. , Ngadjui Bonaventure T.
Published: December 2016

Among the new compounds, trilepisflavene (I), trilepisdepsidone (II) and daturadiol stearate (III), compound (I) exhibits moderate to weak antimicrobial activity.
ChemInform Abstract: Chemical Constituents of the Rare Cliff Plant Oresitrophe rupifragaand Their Antineuroinflammatory Activity.
Authors: Wu Xi‐Ying , Xiong Juan , Liu Xin‐Hua , Hu Jin‐Feng
Published: December 2016

Four new, i.e.
ChemInform Abstract: Surface Chemistry of Carbon Dioxide Revisited
Authors: Taifan William , Boily Jean‐Francois , Baltrusaitis Jonas
Published: December 2016

Review: 418 refs.
ChemInform Abstract: Modular Approach to Spintronics
Authors: Camsari Kerem Yunus , Ganguly Samiran , Datta Supriyo
Published: December 2016

Review: 55 refs.
ChemInform Abstract: Electrochemical Generation of Ozone in a System with a Solid Polymer Electrolyte
Authors: Pushkarev A. S. , Pushkareva I. V. , Grigoriev S. A.
Published: December 2016

Review: 112 refs.
ChemInform Abstract: Energies of Formation Reactions Measured for Adsorbates on Late Transition Metal Surfaces
Authors: Silbaugh Trent L. , Campbell Charles T.
Published: December 2016

Review: 117 refs.
ChemInform Abstract: The Chemistry of Aminoferrocene, Fe{(η5‐C5H4NH2) (η5‐Cp)}: Synthesis, Reactivity and Applications
Authors: Sethi Sipun , Das Pradeep Kumar , Behera Nabakrushna
Published: December 2016

Review: 301 refs.
ChemInform Abstract: Recent Advances in H‐Phosphonate Chemistry. Part 1. H‐Phosphonate Esters: Synthesis and Basic Reactions
Authors: Sobkowski Michal , Kraszewski Adam , Stawinski Jacek
Published: December 2016

Review: 233 refs.
ChemInform Abstract: Synthetic Strategies for 5‐ and 6‐Membered Ring Azaheterocycles Facilitated by Iminyl Radicals
Authors: Walto John C.
Published: December 2016

Review: 156 refs.
ChemInform Abstract: Synthesis of Xanthenones: A Review
Authors: Khanna Radhika , Dalal Aarti , Kumar Ramesh , Kamboj Ramesh C.
Published: December 2016

Review: 66 refs.
ChemInform Abstract: Resorcinarene‐Based Cavitands as Building Blocks for Crystal Engineering
Authors: Pinalli R. , Dalcanale E. , Ugozzoli F. , Massera C.
Published: December 2016

Review: “classic” and recent results concerning their chemistry, applications and crysal structure; 128 refs.
ChemInform Abstract: Thiacalixarenes: Emergent Supramolecules in Crystal Engineering and Molecular Recognition
Authors: Yamada Manabu , Rajiv Gandhi Muniyappan , Kunda Uma Maheswara Rao , Hamada Fumio
Published: December 2016

Review: 127 refs.
ChemInform Abstract: Photochemistry of Nucleic Acid Bases and Their Thio‐ and Aza‐Analogues in Solution
Authors: Pollum Marvin , Martinez‐Fernandez Lara , Crespo‐Hernandez Carlos E.
Published: December 2016

Review: 252 refs.
ChemInform Abstract: Excited States Behavior of Nucleobases in Solution: Insights from Computational Studies
Authors: Improta Roberto , Barone Vincenzo
Published: December 2016

Review: 139 refs.
ChemInform Abstract: Modified Nucleobases
Authors: Matsika Spiridoula
Published: December 2016

Review: photophysical properties; 190 refs.
ChemInform Abstract: Hydrogen Bonding‐Mediated Self‐Assembly of Aromatic Supramolecular Duplexes
Authors: Yang Yong , Chen Chuan‐Feng
Published: December 2016

Review: 50 refs.
ChemInform Abstract: Applications of Palladium‐Catalyzed C—N Cross‐Coupling Reactions
Authors: Ruiz‐Castillo Paula , Buchwald Stephen L.
Published: December 2016

Review: 492 refs.
ChemInform Abstract: Synthesis of Biaryls via Ligand‐Free Suzuki—Miyaura Cross‐Coupling Reactions: A Review of Homogeneous and Heterogeneous Catalytic Developments
Authors: Hussain Ibrar , Capricho Jaworski , Yawer Mirza A.
Published: December 2016

Review: [120 refs.
ChemInform Abstract: Synthesis of Rotaxanes and Catenanes Using an Imine Clipping Reaction
Authors: Han Xie , Liu Guotao , Liu Sheng Hua , Yin Jun
Published: December 2016

Review: [73 refs.
ChemInform Abstract: Future Prospect of the Production of 1,3‐Butadiene from Butanediols
Authors: Duan Hailing , Yamada Yasuhiro , Sato Satoshi
Published: December 2016

Review: 134 refs.
ChemInform Abstract: Photocatalysis in Organic and Polymer Synthesis
Authors: Corrigan Nathaniel , Shanmugam Sivaprakash , Xu Jiangtao , Boyer Cyrille
Published: December 2016

Review: 631 refs.
ChemInform Abstract: Hypervalent Iodine(III) Fluorinations of Alkenes and Diazo Compounds: New Opportunities in Fluorination Chemistry
Authors: Kohlhepp Stefanie V. , Gulder Tanja
Published: December 2016

Review: [73 refs.
ChemInform Abstract: Synthesis of Triazoloquinoxalines
Authors: Baashen Mohammed A. , Abdel‐Wahab Bakr F. , El‐Hiti Gamal A.
Published: December 2016

Review: 63 refs.
ChemInform Abstract: Hydrazone‐Initiated Reaction Cascades
Authors: Chen Po‐An , May Jeremy A.
Published: December 2016

Review: [28 refs.
ChemInform Abstract: Synthetic Methods for 1,3‐Diamines
Authors: Ji Xiaolei , Huang Hanmin
Published: December 2016

Review: 44 refs.
ChemInform Abstract: Diethyl Phosphorocyanidate (DEPC): A Versatile Reagent for Organic Synthesis
Authors: Harusawa Shinya , Shioiri Takayuki
Published: December 2016

Review: 341 refs.
ChemInform Abstract: Non‐Standard Amino Acids and Peptides: From Self‐Assembly to Nanomaterials
Authors: Clerici Francesca , Erba Emanuela , Gelmi Maria Luisa , Pellegrino Sara
Published: December 2016

Review: [67 refs.
ChemInform Abstract: Electrophilic Substitution in meso‐Phenylporphyrins
Authors: Syrbu S. A. , Lyubimtsev A. V. , Ivanov D. A. , Ugarov V. S. , Koifman O. I.
Published: December 2016

Review: 53 refs.
ChemInform Abstract: Mechanistic Understanding of Alkyne Cyclotrimerization on Mononuclear and Dinuclear Scaffolds: [4 + 2] Cycloaddition of the Third Alkyne onto Metallacyclopentadienes and Dimetallacyclopentadienes
Authors: Yamamoto Keishi , Nagae Haruki , Tsurugi Hayato , Mashima Kazushi
Published: December 2016

Review: 108 refs.
ChemInform Abstract: Cyclohepta[b]indoles: A Privileged Structure Motif in Natural Products and Drug Design
Authors: Stempel Erik , Gaich Tanja
Published: December 2016

Review: 91 refs.
ChemInform Abstract: Palladium(II)‐Catalyzed Oxidative Difunctionalization of Alkenes: Bond Forming at a High‐Valent Palladium Center
Authors: Yin Guoyin , Mu Xin , Liu Guosheng
Published: December 2016

Review: 67 refs.
ChemInform Abstract: Multicomponent Hetero‐[4 + 2] Cycloaddition/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery
Authors: Hall Dennis G. , Rybak Taras , Verdelet Tristan
Published: December 2016

Review: 48 refs.
ChemInform Abstract: Visible‐Light‐Driven CO2 Photo‐Catalytic Reduction of Ru(II) and Ir(III) Coordination Complexes
Authors: Liao Wei‐Ming , Zhang Jian‐Hua , Hou Ya‐Jun , Wang Hai‐Ping , Pan Mei
Published: December 2016

Review: 66 refs.
ChemInform Abstract: Recent Developments in Hybrid Iron Oxide‐Noble Metal Nanocatalysts for Organic Reactions
Authors: Woo Hyunje , Park Kang Hyun
Published: December 2016

Review: 120 refs.
ChemInform Abstract: Recent Advancement of Ullmann‐Type Coupling Reactions in the Formation of C—C Bond
Authors: Mondal Shovan
Published: December 2016

Review: 64 refs.
ChemInform Abstract: Asymmetric Reactions Employing 1,3‐Dipoles
Authors: Padwa Albert , Bur Scott
Published: December 2016

Review: 54 refs + subrefs.
ChemInform Abstract: Increasing the Impact of Materials in and Beyond Bio‐Nano Science
Authors: Bjoernmalm Mattias , Faria Matthew , Caruso Frank
Published: December 2016

Review: 130 refs.
ChemInform Abstract: Synthesis, Properties, and Optical Applications of Low‐Dimensional Perovskites
Authors: Zhang Yupeng , Liu Jingying , Wang Ziyu , Xue Yunzhou , Ou Qingdong , Polavarapu Lakshminarayana , Zheng Jialu , Qi Xiang , Bao Qiaoliang
Published: December 2016

Review: 136 refs.
ChemInform Abstract: Emerging Investigators Series: Frontier Review: Occurrence and Speciation of Chromium in Drinking Water Distribution Systems
Authors: Chebeir Michelle , Chen Gongde , Liu Haizhou
Published: December 2016

Review: 74 refs.
ChemInform Abstract: Surface Engineering of Nanomaterials for Improved Energy Storage ‐ A Review
Authors: Share Keith , Westover Andrew , Li Mengya , Pint Cary L.
Published: December 2016

Review: 208 refs.
ChemInform Abstract: Powering the Future: Application of Cellulose‐Based Materials for Supercapacitors
Authors: Perez‐Madrigal Maria M. , Edo Miquel G. , Aleman Carlos
Published: December 2016

Review: 143 refs.
ChemInform Abstract: Recent Advances in Molecular Recognition with Tetrathiafulvalene‐Based Receptors
Authors: Azov Vladimir A.
Published: December 2016

Review: [46 refs.
ChemInform Abstract: Templated Dewetting: Designing Entirely Self‐Organized Platforms for Photocatalysis
Authors: Altomare Marco , Nguyen Nhat Truong , Schmuki Patrik
Published: December 2016

Review: 152 refs.
ChemInform Abstract: Applications of the Conceptual Density Functional Theory Indices to Organic Chemistry Reactivity
Authors: Domingo Luis R. , Rios‐Gutierrez Mar , Perez Patricia
Published: December 2016

Review: 69 refs.
A Bioinspired Nanofibrous Titania/Silicon Composite as an Anode Material for Lithium‐Ion Batteries
Authors: Jia Dongling , Chen Yunhua , Huang Jianguo
Published: December 2016

A hierarchical nanofibrous titania/silicon composite composed of anatase titania nanoparticles anchored as a thin coating layer on the surface of a silicon nanofiber was synthesized by employing natural cellulose substance (e.g., commercial laboratory filter paper) as a template. It was obtained through magnesiothermic reduction of the titania/silica replica of a cellulose substance prepared by a sol–gel process. When used as an anode material for lithium‐ion batteries, it showed improved electrochemical performances that were superior to those of the bare silicon counterpart, and which improved with increasing titania content in the composites. For the composite with 54.3 wt % titania and titania nanoparticles with sizes of about 12 nm, it delivered a specific capacity of 498.9 mA h g−1 after 200 charge/discharge cycles at a current density of 200 mA g−1. The enhanced electrochemical performances of the composite are attributed to its unique network structure, as well as the buffering effect of the titania coating layer for huge volume changes to the silicon fiber during repeated lithiation and delithiation processes.
Development of a Novel Index for Analysis of Electronically Excited States
Authors: Alipour Mojtaba , Damiri Samaneh
Published: December 2016

Concerning the major factors in the context of excited states analyses, namely charge centroids of the orbitals involved in the excitations, the distance between orbital centroids, and overlap integrals, a new metric—the Ω index—is proposed to assign the character and optical properties of electronically excited states. Using several molecules from different classes and also a well‐studied standard database for time‐dependent density functional theory (TD‐DFT) studies as benchmark criteria, accountability of the developed index is numerically assessed for local, charge transfer, and Rydberg excitations. It is shown that the nature of excited states can be discriminated using the Ω index, where its superior performance for those situations in which the previous descriptors were not helpful is also unveiled. Relationships are also examined between the Ω index and optical properties of some molecules under study in the framework of the sum‐over‐state approach. It is observed that there are correlations between the proposed index and computed hyperpolarizabilities based on the sum‐over‐state scheme. These findings offer the possibility of estimating excited‐state properties of large systems from simple descriptors without explicitly performing calculations of high‐order response functions.
Embedded electronic circuits for cryptography, hardware security and true random number generation: an overview
Authors: Acosta Antonio J. , Addabbo Tommaso , Tena‐Sánchez Erica
Published: December 2016

We provide an overview of selected crypto‐hardware devices, with a special reference to the lightweight electronic implementation of encryption/decryption schemes, hash functions, and true random number generators. In detail, we discuss the hardware implementation of the chief algorithms used in private‐key cryptography, public‐key cryptography, and hash functions, discussing some important security issues in electronic crypto‐devices, related to side‐channel attacks (SCAs), fault injection attacks, and the corresponding design countermeasures that can be taken. Finally, we present an overview about the hardware implementation of true random number generators, discussing the chief electronic sources of randomness and the types of post‐processing techniques used to improve the statistical characteristics of the generated random sequences. Copyright © 2016 John Wiley & Sons, Ltd.
New approach for spacing of movement joints in reinforced and unreinforced masonry veneer walls / Neue Bemessungsmethode für die Abstände von Dehnungsfugen in bewehrten und unbewehrten Verblendmauerwerksschalen
Authors: Martens Dirk R.W.
Published: December 2016

The first part of the paper, published in issue 4 [3] and dealing with the spacing of movement joints, described the design method for unreinforced masonry veneer walls. This paper focuses on increasing the spacing of movement joints by applying bed joint reinforcement. The proposed approach enables manufacturers of bed joint reinforcement to provide recommendations for the spacing of movement joints for bed joint reinforced veneer walls dependent upon the allowable crack width, the reinforcement type, the diameter and the vertical spacing of the reinforcement.
Three Solid Modifications of Ba[Ga(NH2)4]2: A Soluble Intermediate in Ammonothermal GaN Crystal Growth
Authors: Hertrampf Jan , Alt Nicolas S. A. , Schlücker Eberhard , Niewa Rainer
Published: December 2016

Ammonothermally grown GaN crystals are highly demanded as superior substrates for manufacturing high‐performance blue and white LEDs. Ba or Ba(NH2)2 can act as effective mineralizers under ammonothermal conditions (523 K, 110–150 MPa) and lead to the formation of barium bis(tetramidogallate), Ba[Ga(NH2)4]2, a new intermediate in h‐GaN synthesis, which was obtained in three solid forms. Single crystals of all three modifications were characterized by X‐ray diffraction techniques. Like earlier characterized intermediates in ammonobasic GaN crystal growth, all forms of Ba[Ga(NH2)4]2 contain isolated [Ga(NH2)4]– units. Differences between the forms originate in the coordination environments of Ba, leading to various frameworks with the [Ga(NH2)4]– complex ions. Raman and IR spectroscopic data are discussed. Ba[Ga(NH2)4]2 in an inert gas thermally decomposes in several steps to finally yield the intermetallic compound BaGa2.
Quantitative analysis of single‐nucleotide polymorphisms by pyrosequencing with di‐base addition
Authors: Pu Dan , Pan Rongfang , Liu Wenbin , Xiao Pengfeng
Published: December 2016

We have developed and validated a novel method for quantitative detection of SNPs by using pyrosequencing with di‐base addition (PDBA). Based on the principle that the signal intensity is proportional to the template concentration within a linear concentration range, linear formula (Y = AX + B) for each genotype is established, and the relationship between two genotypes of a single SNP can be resolved by corresponding linear formulas. Here, PDBA assays were developed to detect variants rs6717546 and rs4148324, and the linear formulas for each genotype of rs6717546 and rs4148324 were established. The method allowed to quantitatively determine each genotype and showed 100% accordant results against a panel of defined mixtures. A set of 24 template fragments containing variants rs6717546 or rs4148324 was tested to evaluate the method. Our results showed that allele frequency of each genotype was accurately quantified, with results comparable to those of conventional pyrosequencing. Furthermore, this method was capable of detecting alleles with frequencies as low as 3%, which was more sensitive than ∼5 to ∼7% level detected by conventional pyrosequencing. This method offers high sensitivity, reproducibility, and relatively low costs, and thus could provide a much‐needed approach for quantitative analysis of SNPs in clinical samples.
Oblique aggradation: a novel explanation for sinuosity of low‐energy streams in peat‐filled valley systems
Authors: Candel Jasper H.J. , Makaske Bart , Storms Joep E.A. , Wallinga Jakob
Published: December 2016

Low‐energy streams in peatlands often have a high sinuosity. However, it is unknown how this sinuous planform formed, since lateral migration of the channel is hindered by relatively erosion‐resistant banks. We present a conceptual model of Holocene morphodynamic evolution of a stream in a peat‐filled valley, based on a palaeohydrological reconstruction. Coring, ground‐penetrating radar (GPR) data, and 14C and OSL dating were used for the reconstruction. We found that the stream planform is partly inherited from the Late‐Glacial topography, reflecting stream morphology prior to peat growth in the valley. Most importantly, we show that aggrading streams in a peat‐filled valley combine vertical aggradation with lateral displacement caused by attraction to the sandy valley sides, which are more erodible than the co‐evally aggrading valley‐fill. Owing to this oblique aggradation in combination with floodplain widening, the stream becomes stretched out as channel reaches may alternately aggrade along opposed valley sides, resulting in increased sinuosity over time. Hence, highly sinuous planforms can form in peat‐filled valleys without the traditional morphodynamics of alluvial bed lateral migration. Improved understanding of the evolution of streams provides inspiration for stream restoration. Copyright © 2016 John Wiley & Sons, Ltd.
An evaluation of the endocrine disruptive potential of crude oil water accommodated fractions and crude oil contaminated surface water to freshwater organisms using in vitro and in vivo approaches
Authors: Truter J. Christoff , van Wyk Johannes H. , Oberholster Paul J. , Botha Anna-Maria , Mokwena Lucky M.
Published: December 2016

Knowledge regarding the potential impacts of crude oil on endocrine signaling in freshwater aquatic vertebrates is limited. The expression of selected genes as biomarkers for altered endocrine signaling was studied in African clawed frog, Xenopus laevis, tadpoles and juvenile Mozambique tilapia, Oreochromis mossambicus, exposed to weathered bunker and unweathered refinery crude oil water accommodated fractions (WAFs). In addition, the expression of the aforementioned genes was quantified in X. laevis tadpoles exposed to surface water collected from the proximity of an underground oil bunker. The (anti)estrogenicity and (anti)androgenicity of crude oil, crude oil WAFs, and surface water were furthermore evaluated using recombinant yeast. Thyroid hormone receptor beta expression was significantly down-regulated in X. laevis in response to both oil WAF types, whereas a further thyroid linked gene, type 2 deiodinase, was up-regulated in O. mossambicus exposed to a high concentration of bunker oil WAF. In addition, both WAFs altered the expression of the adipogenesis-linked peroxisome proliferator–activated receptor gamma in X. laevis. The crude oil and WAFs exhibited antiestrogenic and antiandrogenic activity in vitro. However, O. mossambicus androgen receptor 2 was the only gene, representing the reproductive system, significantly affected by WAF exposure. Estrogenicity, antiestrogenicity, and antiandrogenicity were detected in surface water samples; however, no significant changes were observed in the expression of any of the genes evaluated in X. laevis exposed to surface water. The responses varied among the 2 model organisms used, as well as among the 2 types of crude oil. Nonetheless, the data provide evidence that crude oil pollution may lead to adverse health effects in freshwater fish and amphibians as a result of altered endocrine signaling. Environ Toxicol Chem 2017;36:1330–1342. © 2016 SETAC
Synthesis of new functionalized mono‐ and diphosphonic acids with five‐membered aza‐heterocycles moieties
Authors: Prishchenko Andrey A. , Alekseyev Roman S. , Livantsov Mikhail V. , Novikova Olga P. , Livantsova Ludmila I. , Terenin Vladimir I. , Petrosyan Valery S.
Published: December 2016

The new functionalized hydroxymethylphosphonic and methylenediphosphonic acids are synthesized via unique reaction of tris(trimethylsilyl)phosphite and N‐formyl derivatives of five‐membered aza‐heterocycles at the presence of effective catalyst—trimethylsilyl triflate.
Synthesis of 2‐Substituted 2‐Amino Ketones by Rhodium‐Catalyzed Reaction of N‐Sulfonyl‐1,2,3‐triazoles with 2‐Alkenols
Authors: Miura Tomoya , Tanaka Takamasa , Zhao Qiang , Stewart Scott G. , Murakami Masahiro
Published: December 2016

A study on a rhodium(II)‐catalyzed reaction of N‐sulfonyl‐1,2,3‐triazoles with 2‐alkenols is reported. The reaction is initiated by insertion of an α‐imino carbene into the O–H linkage of alcohol, forming a 2‐alkenoxy enamide intermediate. A thermal [3,3]‐sigmatropic rearrangement follows to yield 2‐substituted 2‐amino ketone in a stereoselective manner. The successful application of this methodology to a formal synthesis of (–)‐α‐conhydrine is also described.
PSYCHOLOGY OF BOYS AT RISK: INDICATORS FROM 0–5
Authors: Golding Paul , Fitzgerald Hiram E.
Published: December 2016

In utero and during the first 5 years of life, boys face unique risks as a result of neurobiological and environmental factors. This introductory article to the Special Issue describes the background of this gender‐specific inquiry and outlines some of those risks, drawing attention to the areas that will be covered in depth in the following contributions. We also describe the basis of this inquiry as the link between early life and the subsequent difficulties that adolescent boys and many young men face, and pay particular attention to the circumstances of young men of color and to the growing knowledge about the contributions of fathers to boys’ development.
Transnational Chinese Students’ Literacy and Networking Practices
Authors: Wang Xiqiao
Published: December 2016

Situated in the context of a first‐year writing course at a Midwestern public university in the United States, this study examines Chinese international students' networking practices through the mediation of WeChat, a popular social networking application for smartphones. Based on interviews with 36 students and detailed accounts of one focal student's activities in WeChat study groups, this study shows that students' literacy practices and identities are dynamically co‐constructed with intersecting local and global forces. Social theories of identity and the Chinese concept ofguanxi(carefully cultivated personal connections that are used to gain social advantages) provide ways to examine identities at the intersection of local and distant circumstances and practices that span geographical and linguistic spaces. Findings reveal the implications of such identity work on students' social and academic experiences, while encouraging teachers to consider pedagogical practices that leverage students' rich cultural and linguistic knowledge.
Evaluation of a novel point‐of‐care test kit, ABSOGEN™ PCT, in semi‐quantitative measurement of procalcitonin in whole blood
Authors: Kwon Hi Jeong , Lee Jehoon , Park Hae‐il , Han Kyungja
Published: December 2016

Background

In response to inflammation, procalcitonin plasma concentrations increase more rapidly than other acute‐phase reactants and higher values are associated with severe disease. Procalcitonin measurements assist in determining whether antibiotic therapy should be used. point‐of‐care testing (POCT) is performed for early decision making about additional testing or therapy. The ABSOGEN™ PCT (Bumyoungbio, Inc., Suwon, Korea) is a rapid novel semi‐quantitative immunochromatographic PCT assay that analyses whole blood samples. We compared the patient quantitative test results to ABSOGEN™ PCT test results.

Methods

Whole blood was loaded onto an ABSOGEN™ PCT cartridge and incubated for 10 minutes. The color intensity of the band of the cartridge was measured using an accompanying device and with the naked eye. The results were graded as negative (<0.1 ng/mL), low (0.1 to <1.0 ng/mL), middle (1.0‐2.0 ng/mL), and high (>2.0 ng/mL). A total of 158 specimens with procalcitonin levels measured from 0 to 18.96 ng/mL were used for comparison study.

Results

The concordance rate between ABSOGEN™ PCT using the reader and quantitative assay, between ABSOGEN™ PCT using naked eyes and quantitative assay, and between ABSOGEN™ PCT using the reader and naked eyes for the same category was 83.5% (P=.040), 78.5% (P<.001), and 82.3% (P=.001), respectively. The concordance rates for the ±1 categories were all 100%.

Conclusion

ABSOGEN™ PCT is an accurate assay. It is easy to use, simple, fast, portable. The assay has potential value in clinical applications, especially in emergency care.
Serum TNF‐α levels in children with congenital heart disease undergoing cardiopulmonary bypass: A cohort study in China and a meta‐analysis of the published literature
Authors: Song Shu‐Tian , Bai Chuan‐Ming , Zhou Ji‐Wu
Published: December 2016

Objective

To investigate the changes in tumor necrosis factor alpha (TNF‐α) serum levels after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD), followed by a meta‐analysis to analyze the clinical value of TNF‐α in CPB.

Methods

Our cohort study enrolled 67 CHD children, assigned into off‐pump group (n=32) and CPB group (n=35). The TNF‐α serum levels in two groups were detected by ELISA before the operation (T1), at the end of the operation (0 hour, T2), and after 24 hours of the operation (T3). For meta‐analysis, literature search was conducted to identify published case‐control articles about the changes of TNF‐α serum levels with CPB of CHD.

Results

The TNF‐α levels in CPB group were lower than that in the off‐pump group at T3 (P=.006). TNF‐α level at T3 was significantly lower than that at T1 and T2 (all P<.05). Meta‐analysis results further confirmed that the TNF‐α levels of CHD children were dramatically decreased at T3 as compared to that at T1 and T2 (both P<.001).

Conclusion

The TNF‐α serum levels showed a transient and dramatic decline after 24 hours of CPB, and it may act as an important biological indicator for monitoring the efficacy of CPB in CHD children.