bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole Exome Sequencing Reveals Novel Candidate Genes in Familial Forms of Glaucomatous Neurodegeneration
Authors: Narta Kiran , Teltumbade Manoj Ramesh , Vishal Mansi , Sadaf Samreen , Faruq Mohd. , Jama Hodan , Waseem Naushin , Rao Aparna , Sen Abhijit , Ray Kunal , Mukhopadhyay Arijit
Published: February 2023

Glaucoma is the largest cause of irreversible blindness with a multifactorial genetic etiology. This study explores novel genes and gene networks in familial forms of primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) to identify rare mutations with high penetrance. Thirty-one samples from nine MYOC-negative families (five POAG and four PACG) underwent whole-exome sequencing and analysis. A set of prioritized genes and variations were screened in an independent validation cohort of 1536 samples and the whole-exome data from 20 sporadic patients. The expression profiles of the candidate genes were analyzed in 17 publicly available expression datasets from ocular tissues and single cells. Rare, deleterious SNVs in AQP5, SRFBP1, CDH6 and FOXM1 from POAG families and in ACACB, RGL3 and LAMA2 from PACG families were found exclusively in glaucoma cases. AQP5, SRFBP1 and CDH6 also revealed significant altered expression in glaucoma in expression datasets. Single-cell expression analysis revealed enrichment of identified candidate genes in retinal ganglion cells and corneal epithelial cells in POAG; whereas for PACG families, retinal ganglion cells and Schwalbe’s Line showed enriched expression. Through an unbiased exome-wide search followed by validation, we identified novel candidate genes for familial cases of POAG and PACG. The SRFBP1 gene found in a POAG family is located within the GLC1M locus on Chr5q. Pathway analysis of candidate genes revealed enrichment of extracellular matrix organization in both POAG and PACG.
Spondyloocular Syndrome: A Report of an Additional Family and Phenotypic Spectrum Delineation
Authors: Chouery Eliane , Karam Rim , Mrad Yves Najm , Mehawej Cybel , Dib El Jalbout Nahia , Bleik Jamal , Mahfoud Daniel , Megarbane Andre
Published: February 2023

Spondyloocular syndrome (SOS, OMIM # 605822) is a rare genetic disorder characterized by osseous and ocular manifestations, including generalized osteoporosis, multiple long bones fractures, platyspondyly, dense cataracts and retinal detachment, and dysmorphic facial features, with or without short stature, cardiopathy, hearing impairment, and intellectual disability. Biallelic mutations in the XYLT2 gene (OMIM * 608125), encoding the xylosyltransferase II, were shown to be responsible for this disease. To date, 22 cases with SOS have been described, with varying clinical presentations and a yet-to-be-established genotypic–phenotypic correlation. Two patients from a consanguineous Lebanese family that presented with SOS were included in this study. Whole exome sequencing revealed a novel homozygous nonsense mutation in XYLT2 (p.Tyr414*) in these patients. We review all previously reported cases with SOS, describe the second nonsense mutation in XYLT2, and contribute to a better delineation of the phenotypic spectrum of the disease.
Spatial Variability during Shrinkage Testing of Expansive Clays
Authors: Paranthaman Rajeevkaran , Suchan Jared , Azam Shahid
Published: February 2023

Civil infrastructure constructed with, buried in, or underlain by expansive clays is affected by high volumetric changes, especially because large-scale facilities are spatially distributed. This research focused on determining spatial variability during the shrinkage testing of expansive clays. An initially saturated sample (600 mm in diameter) of a high-plasticity clay was exposed to desiccation and thoroughly monitored over five months. The results indicated an expansive clay (30% smectite and 14% illite) in alkaline-pore water (695 mg/L Na+ and 1150 mg/L SO42−) for developing a dispersive soil fabric. The vertical shrinkage in the intact-soil portion was unchanged (remaining at 114 × 106 mm3) in the first 10 days, sharply decreased the initial volume by 30% (up to 280 mm or 80 × 106 mm3) in 68 days, and slowly decreased the initial volume by 40% (up to 240 mm or 68 × 106 mm3) in 145 days. Furthermore, the soil temperature was found to be 10% lower than the air temperature, whereas the relative humidity within the cell was found to be 30% higher than that outside the cell. The soil showed an initial prominent central ridge with a few cracks that gradually evolved into a distinct crack pattern with equal-sized and irregular soil chunks. The average soil surface showed no volume reduction up to 18 days and a subsequent linear reduction, reaching 25% of the initial soil volume by the end of the test.
Effects of Stroke Rehabilitation Using Gait Robot-Assisted Training and Person-Centered Goal Setting: A Single Blinded Pilot Study
Authors: Ha Yeongmi , Park Mingyeong
Published: February 2023

Many stroke survivors have difficulties due to the mobility and activities required in daily living. A walking impairment negatively affects the independent lifestyle of stroke patients, requiring intensive post-stroke rehabilitation. Therefore, the purpose of this study was to examine the effects of stroke rehabilitation using gait robot-assisted training and person-centered goal setting on mobility, the activities of daily living, stroke self-efficacy, and health-related QoL in stroke patients with hemiplegia. An assessor-blinded quasi-experimental study with a pre-posttest nonequivalent control group was used. Participants who were admitted to the hospital with a gait robot-assisted training system were assigned to the experimental group, and those without gait robots were assigned to the control group. Sixty stroke patients with hemiplegia from two hospitals specialized in post-stroke rehabilitation participated. Stroke rehabilitation using gait robot-assisted training and person-centered goal setting for stroke patients with hemiplegia was conducted for a total of six weeks. There were significant differences between the experimental group and control group in the Functional Ambulation Category (t = 2.89, p = 0.005), balance (t = 3.73, p < 0.001), Timed Up and Go (t = −2.27, p = 0.027), Korean Modified Barthel Index (t = 2.58, p = 0.012), 10 m Walking test (t = −2.27, p = 0.040), stroke self-efficacy (t = 2.23, p = 0.030), and health-related quality of life (t = 4.90, p < 0.001). A gait robot-assisted rehabilitation using goal setting for stroke patients with hemiplegia improved gait ability, balance ability, stroke self-efficacy, and health-related quality of life in stroke patients.
The Impact of Bevacizumab and Chemotherapy on Quality of Life in Metastatic Colorectal Cancer Patients
Authors: Moisuc Diana Cornelia , Marinca Mihai Vasile , Matei Andreea Mihaela , Popovici Larisa , Cianga Petru
Published: February 2023

Health-related quality is of life of great importance in cancer care. This prospective study aimed to evaluate the impact of chemotherapy and bevacizumab on the activities of daily living, cancer symptoms, and general well-being in 59 metastatic colorectal cancer patients. We gathered information using the EORTC QLQ-C30 and QLQ-CR29 questionnaires. The paired sample t-test, MANOVA test, and Pearson’s correlation test were used to analyze the presence of significant differences in mean scores before and after 6 months of treatment. The results revealed significant differences in the functioning and symptoms that influence patients’ quality of life after 6 months of treatment: increased pain (p = 0.003), nausea and vomiting (p = 0.003), diarrhea (p = 0.021) and decreased appetite (p = 0.003). At the same time, there were several aspects that improved the quality of life. Increases in emotional function (p = 0.009), cognitive function (p = 0.033), and perception of body image (p = 0.026) were observed after 6 months of treatment. Elderly patients reported a higher frequency of stools (p = 0.028), and young patients had increased concerns about body perception (p = 0.047). Assessing the quality of life of metastatic colorectal cancer patients is an important way to identify and treat symptoms related to both cancer and therapy by establishing a holistic care plan and implementing measures to increase the quality of life.
“I Needed to Know, No Matter What I Do, I Won’t Make It Worse”—Expectations and Experiences of Last Aid Course Participants in Germany—A Qualitative Pilot Study
Authors: Giehl Chantal , Chikhradze Nino , Bollig Georg , Vollmar Horst Christian , Otte Ina
Published: February 2023

Background: The need to care for a loved one in a palliative state can lead to severe physical as well as psychological stress. In this context, Last Aid courses have been developed to support caring for relatives and to stimulate the public discussion on death and dying. The purpose of our pilot study is to gain an understanding of the attitudes, values, and difficulties of relatives caring for a terminally ill person. Methods: A qualitative approach was used in form of five semi-structured guided pilot interviews with lay persons who recently attended a Last Aid course. The transcripts of the interviews were analyzed following Kuckartz’s content analysis. Results: Overall, the interviewed participants have a positive attitude toward Last Aid courses. They perceive the courses as helpful as they provide knowledge, guidance, and recommendations of action for concrete palliative situations. Eight main topics emerged during analysis: expectations regarding the course, transfer of knowledge, reducing fear, the Last Aid course as a safe space, support from others, empowerment and strengthening of own skills, and the improvement needs of the course. Conclusions: In addition to the expectations before participation and the knowledge transfer during the course, the resulting implications for its application are also of great interest. The pilot interviews show initial indications that the impact, as well as supportive and challenging factors regarding the ability to care for relatives to cope, should be explored in further research.
Global Cultural Conflict and Digital Identity: Transforming Museums
Authors: Giannini Tula , Bowen Jonathan
Published: February 2023

This paper looks at key elements of global culture that are driving a new paradigm shift in museums causing them to question their raison d’être, their design and physical space, recognizing the need to accommodate visitor interaction and participation, and to reprioritize institutional outcomes and goals reexamining their priorities. As heritage sharing in online spaces reaches across national, political, and social boundaries on platforms and networks, this has been driven by museum engagement with Internet life during the pandemic. Museum relationships and interactions with communities both local and global continue to challenge core values and precepts, leading to radical changes in how museums define their roles and responsibilities. In this new cultural landscape, museums are responding to human digital identity in a tidal wave of human interactions on the Internet, from social media to online sharing of images and videos. This is revealing shared perspectives on cultural conflict as being tied to freedom of expression of one’s heritage embedded in digital identity.
Genetic Components of Self-Incompatibility in Brassica Vegetables
Authors: Wang Fenghua , Li Yufei , Li Guangyuan , Chen Shuangchen
Published: February 2023

Brassica vegetables are very important to human beings. Self-incompatibility (SI) is a common phenomenon in Brassica. Breeding by SI lines is an important way to utilize heterosis of Brassica vegetables. It is believed that the SI inheritance in Brassica species is controlled by three linkage genes on the S-locus, including SRK (S-locus receptor kinase), SCR (S-locus cystine-rich protein)/SP11 (S-locus protein 11), and SLG (S-locus glycoprotein). SRK is the female determinant and SCR/SP11 is the pollen S gene. The expression of SLG is necessary for SRK, and it enhances the SRK-mediated SI reaction. In addition to these three S-locus genes, some other functional molecules also have significant regulatory effects on SI, such as ARC1 (arm repeat containing 1), MLPK (M-locus protein kinase), Exo70A1 (exocyst compounds), THLl/THL2 (thioredoxin H-like), MOD (aquaporin), SLR (S-locus-related glycoprotein), BPCI (pollen calcium-binding protein I), etc. SI is also associated with the dominant/recessive relationship between S alleles. Here, the genetic elements and molecular mechanisms of SI, mainly in Brassica vegetables, are reviewed.
UAV Photogrammetry-Based Apple Orchard Blossom Density Estimation and Mapping
Authors: Yuan Wenan , Hua Weiyun , Heinemann Paul Heinz , He Long
Published: February 2023

Thinning is an important routine for apple growers to manage crop load and improve fruit quality, which can be accomplished through manual, chemical, or mechanical manipulation of flowers and fruitlets. Traditionally, blossom thinning relies on human experts’ visual evaluation of the flower load, a leading indicator of crop load, which can be imprecise and prone to errors. This study aimed to develop an apple blossom density mapping algorithm utilizing point clouds reconstructed through unmanned aerial vehicle (UAV)-based red-green-blue (RGB) imagery and photogrammetry. The algorithm was based on grid average downsampling and white color thresholding, and it was able to generate top-view blossom density maps of user-defined tree height regions. A preliminary field experiment was carried out to evaluate the algorithm’s accuracy using manual blossom counts of apple tree row sections as ground truths, and a coefficient of determination (R2) of 0.85, a root mean square error (RMSE) of 1307, and a normalized RMSE (NRMSE) of 9.02% were achieved. The algorithm was utilized to monitor the blooming of the apple tree rows and was demonstrated to effectively show blossom density variations between different tree rows and dates. The study results suggested the potential of UAVs as a convenient tool to assist precise blossom thinning in apple orchards, while future research should further investigate the reliability of photogrammetry techniques under different image qualities and flight settings as well as the influence of blossom distribution on algorithm accuracy.
Changes in Physical Fitness Parameters in a Portuguese Sample of Adolescents during the COVID-19 Pandemic: A One-Year Longitudinal Study
Authors: Silva Cátia , Vilas Catarina , Pereira Beatriz , Rosário Pedro , Fuentes Sonia , Magalhães Paula
Published: February 2023

Due to a worldwide response to the COVID-19 pandemic, many changes were imposed on individuals’ daily lives, including those related to the physical activity of children and adolescents. The present study aims to comprehend the impact of early COVID-19 pandemic restrictions on Portuguese adolescents’ physical fitness parameters during two school years. A total of 640 students from the 5th to the 12th grades participated in the longitudinal study. Data on body composition, aerobic fitness, speed, agility, lower and upper body strength, and flexibility were collected at three moments: 1. before the COVID-19 pandemic (December 2019); 2. after the COVID-19 lockdown when the schools reopened delivering in-person classes (October 2020), and 3. two months after the in-person classes started (December 2020). To analyze the overall changes between the three moments and between two age groups, we conducted repeated measure ANOVAs. The main findings indicate that participants’ body composition (i.e., waist circumference) and aerobic fitness (i.e., maximal oxygen uptake) deteriorated after the first lockdown but improved two months after the in-person classes started. However, the same did not happen to neuromuscular fitness (i.e., horizontal Jumps and Sit and Reach). These findings suggest that the COVID-19 lockdown may have negatively impacted adolescents’ physical fitness, particularly older adolescents. Altogether, data reinforce the importance of in-person classes and school context in promoting adolescents’ physical health.
Allocation of Land Factors in China Looking Forward to 2035: Planning and Market
Authors: Wu Yuzhe , Ao Jia , Ren Yuhang
Published: February 2023

Land factors are natural resources with fundamental and strategic significance in the achievement of China’s 2035 modernization goals. Dilemmas caused by market-oriented or planning-oriented allocation of land factors urgently call for new theoretical guidance and mode. After conducting a systematic review of the literature, this paper built a new framework from the perspective of production–living–ecological spaces to facilitate a better understanding of China’s land factors allocation looking forward to 2035. Inductive and deductive methods were both used to interpret the applications of planning and market in land factors allocation. Our results show that: (1) The allocation of land factors for production space is truth-oriented and needs the guidance of market efficiency. The essential feature of “production” as the driving force in production space requires that the allocation of land factors in production space must “respect rules, give play to the agglomeration effect, and rationally carry out regional economic layout”. (2) For the allocation of land factors for living space, it is necessary to pursue a kindness-oriented approach and establish a reasonable housing supply system based on people. Among them, the ordinary commercial housing and improving housing should rely on market forces to achieve multi-subject supply, while affordable housing should be ensured through government intervention in a multi-channel way. (3) For the allocation of land factors in ecological space, aesthetic-oriented planning should follow the rule of territorial differentiation and realize the transformation of ecological function into ecological value through market mechanisms. Top-down planning and bottom-up market represents the logic of overall and individual rationality, respectively. The effective allocation of land factors requires the utilization of both planning and market forces. However, the intersection needs be guided by boundary selection theory. This research indicates that “middle-around” theory could be a possible theoretical solution for future study.
Callous-Unemotional Traits and Social Adjustment among Chinese Preschoolers: The Moderating Role of Teacher-Child Relationship
Authors: Zhu Jingjing , Xia Xiaoying , Wu Qianqian , Zou Shiyao , Li Yan
Published: February 2023

Callous-unemotional (CU) traits are associated with social adjustment difficulties, but few studies have examined the underlying mechanisms in Chinese preschoolers. This study examined the relationship between CU traits and social adjustment among Chinese preschoolers as well as the moderating role of the teacher-child relationship in the association. Participants were 484 preschool children aged 3–6 years old from Shanghai, China (Mage = 5.56 years, SD = 0.96 years). Parents reported children’s CU traits and teachers reported their relationship with children and rated children’s social adjustment as well. The results revealed that (1) children with higher CU traits positively related to aggressive and asocial behavior with peers, but negatively related to prosocial behavior; (2) the teacher-child relationship moderated the relationship between CU traits and social adjustment in children. Specifically, teacher-child conflict exacerbated the aggressive and asocial behavior of children with CU traits and reduced the prosocial behavior of children with CU traits. These findings extended the current research on CU traits and had important implications for early interventions targeted at children with CU traits.
The Influence of Fatigue on the Characteristics of Physiological Tremor and Hoffmann Reflex in Young Men
Authors: Mazur-Różycka Joanna , Gajewski Jan , Orysiak Joanna , Sitkowski Dariusz , Buśko Krzysztof
Published: February 2023

The aim of the study was to determine the relationship between changes in physiological tremor after exercise and changes in the traction properties of the stretch reflex indirectly assessed using the Hoffmann reflex test. The research involved 19 young men practicing canoe sprint (age 16.4 ± 0.7 years, body mass 74.4 ± 6.7 kg, body height 182.1 ± 4.3 cm, training experience 4.8 ± 1.6 years). During resting tests, Hoffmann reflex measurements were performed from the soleus muscle, physiological tremor of the lower limb, and the blood lactate concentration was determined. Then, a graded test was carried out on the kayak/canoe ergometer. Immediately after the exercise and in the 10th and 25th minute following the exercise, Hoffmann’s reflex of the soleus muscle was measured. The physiological tremor was measured at 5, 15 and 30 min after exercise. Blood lactate concentrations were determined immediately after physiological tremor. Both the parameters of Hoffmann’s reflex and physiological tremor changed significantly after exercise. There were no significant interrelationships between Hoffmann reflex measurements and physiological tremor in resting and post-exercise conditions. No significant correlation was detected between changes in physiological tremor and changes in Hoffmann reflex parameters. It is to be assumed that there is no connection between a stretch reflex and a physiological tremor.
A Novel Social Distancing Approach for Limiting the Number of Vehicles in Smart Buildings Using LiFi Hybrid-Network
Authors: Murad Sallar Salam , Yussof Salman , Badeel Rozin , Hashim Wahidah
Published: February 2023

The coronavirus (COVID-19) has arisen as one of the most severe problems due to its ongoing mutations as well as the absence of a suitable cure for this virus. The virus primarily spreads and replicates itself throughout huge groups of individuals through daily touch, which regretfully can happen in several unanticipated way. As a result, the sole viable attempts to constrain the spread of this new virus are to preserve social distance, perform contact tracing, utilize suitable safety gear, and enforce quarantine measures. In order to control the virus’s proliferation, scientists and officials are considering using several social distancing models to detect possible diseased individuals as well as extremely risky areas to sustain separation and lockdown procedures. However, models and systems in the existing studies heavily depend on the human factor only and reveal serious privacy vulnerabilities. In addition, no social distancing model/technique was found for monitoring, tracking, and scheduling vehicles for smart buildings as a social distancing approach so far. In this study, a new system design that performs real-time monitoring, tracking, and scheduling of vehicles for smart buildings is proposed for the first time named the social distancing approach for limiting the number of vehicles (SDA-LNV). The proposed model employs LiFi technology as a wireless transmission medium for the first time in the social distance (SD) approach. The proposed work is considered as Vehicle-to-infrastructure (V2I) communication. It might aid authorities in counting the volume of likely affected people. In addition, the proposed system design is expected to help reduce the infection rate inside buildings in areas where traditional social distancing techniques are not used or applicable.
Exploring and Mapping Screening Tools for Cognitive Impairment and Traumatic Brain Injury in the Homelessness Context: A Scoping Review
Authors: Fearn-Smith Erin M. , Scanlan Justin Newton , Hancock Nicola
Published: February 2023

Cognitive impairment is common amongst people experiencing homelessness, yet cognitive screening and the collection of history of brain injury rarely features in homelessness service delivery practice. The purpose of this research was to scope and map strategies for screening for the potential presence of cognitive impairment or brain injury amongst people experiencing homelessness and identify instruments that could be administered by homelessness service staff to facilitate referral for formal diagnosis and appropriate support. A search was conducted across five databases, followed by a hand search from relevant systematic reviews. A total of 108 publications were included for analysis. Described in the literature were 151 instruments for measuring cognitive function and 8 instruments screening for history of brain injury. Tools that were described in more than two publications, screening for the potential presence of cognitive impairment or history of brain injury, were included for analysis. Of those regularly described, only three instruments measuring cognitive function and three measuring history of brain injury (all of which focused on traumatic brain injury (TBI)) may be administered by non-specialist assessors. The Trail Making Test (TMT) and the Ohio State University Traumatic Brain Injury Identification Method (OSU TBI-ID) are both potentially viable tools for supporting the identification of a likely cognitive impairment or TBI history in the homelessness service context. Further population-specific research and implementation science research is required to maximise the potential for practice application success.
Cost–Benefit of Real-Time Multiplex PCR Testing of SARS-CoV-2 in German Hospitals
Authors: Diel Roland , Nienhaus Albert
Published: February 2023

Background: The current Omicron COVID-19 pandemic has significant morbidity worldwide. Objective: Assess the cost–benefit relation of implementing PCR point-of-care (POCT) COVID-19 testing in the emergency rooms (ERs) of German hospitals and in the case of inpatient admission due to other acute illnesses. Methods: A deterministic decision-analytic model simulated the incremental costs of using the Savanna® Multiplex RT-PCR test compared to using clinical judgement alone to confirm or exclude COVID-19 in adult patients in German ERs prior to hospitalization or just prior to discharge. Direct and indirect costs were evaluated from the hospital perspective. Nasal or nasopharyngeal swabs of patients suspected to have COVID-19 by clinical judgement, but without POCT, were sent to external labs for RT-PCR testing. Results: In probabilistic sensitivity analysis, assuming a COVID-19 prevalence ranging between 15.6–41.2% and a hospitalization rate between 4.3–64.3%, implementing the Savanna® test saved, on average, €107 as compared to applying the clinical-judgement-only strategy. A revenue loss of €735 can be avoided when SARS-CoV-2 infection in patients coming unplanned to the hospital due to other acute illnesses are excluded immediately by POCT. Conclusions: Using highly sensitive and specific PCR-POCT in patients suspected of COVID-19 infection at German ERs may significantly reduce hospital expenditures.
Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population
Authors: Chung Pei-Ting , Ma Hsiao-Chi , Huang Sin-Yi , Lien Hsin-Ning , Ho Kuan-Hsun , Hsu Hsin-Yin , Hwang Lee-Ching , Tsou Meng-Ting , Lin Hsin-Hui , Chan Hsin-Lung
Published: February 2023

Osteoporosis is a progressive metabolic bone disorder characterised by a decline in bone mineral density (BMD). Some previous studies have reported a controversial relationship between uric acid and osteoporosis. This cross-sectional study aimed to assess the association between serum uric acid levels and BMD in older adults from Taiwan. Data from participants aged ≥ 60 years were collected from 2008 to 2018. Furthermore, the participants were classified based on uric acid level quartiles. Regression models were used to assess the association between uric acid levels and bone health, including BMD values and risk of at least osteopenia. Crude and adjusted models of potential confounders, including age, sex and body mass index (BMI), were used. Compared with the first quartile of uric acid levels, the odds ratios for osteoporosis decreased in the higher uric acid level groups after adjustment for age, sex and BMI. The boxplot analysis showed that BMD values were higher in the groups with higher uric acid levels; moreover, the results of the multivariable linear regression model showed a consistent pattern. Notably, uric acid levels were positively correlated with BMD values. Higher uric acid levels in the elderly population might decrease the risk of at least osteopenia. As opposed to the anti-hyperuricemic policy for younger adults with a relatively lower risk of osteoporosis, BMD evaluation and urate-lowering therapy, goal adjustments should be considered for older adults with lower uric acid levels.
Limitations in Activities of Daily Living among Older Adults with COPD, Asthma, or Asthma-COPD Overlap Residing in Spain
Authors: Sánchez Castillo Sheila , Smith Lee , Díaz Suárez Arturo , López Sánchez Guillermo Felipe
Published: February 2023

Activities of daily living (ADL) may be limited by the presence of chronic diseases, and limitations in ADL contribute to an increased risk of falling. In people with asthma, chronic obstructive pulmonary disease (COPD), and asthma–COPD overlap (ACO), ADL may be affected owing to poor asthma control and COPD ventilatory limitations. The aim of this study was to establish the differing prevalence of limitations in ADL among older Spanish adults with chronic respiratory diseases (COPD, asthma, and ACO). Data from the Spanish National Health Survey were analyzed. The sample was composed of 944 older adults aged ≥65 years and with a positive diagnosis of COPD (n = 502), asthma (n = 241), or ACO (n = 201). Five basic activities of daily living (BADL) and seven instrumental activities of daily living (IADL) were studied. Frequency and percentages were used to describe sample characteristics and limitations of ADL. Significant differences were analyzed using chi-square tests. Results revealed a significant higher number of older adults with COPD (34.8%) and asthma (32.5%) without limitations in doing hard housework in comparison to ACO (17.8%). Regarding meal preparation, a higher percentage of asthmatics without difficulties (77.7%) and a lower percentage with many difficulties (2.6%) were observed in comparison to ACO (64.8%–10.2%). No differences were found in BADL, with approximately 80–90% without limitations. It seems that limitations in IADL vary according to the type of chronic pulmonary diseases, but further research is needed to clarify why differences were found only for preparing meals and hard housework. These findings should be considered in the design of interventions to promote ADL in older adults with respiratory disease.
Odontogenic-Related Head and Neck Infections: From Abscess to Mediastinitis: Our Experience, Limits, and Perspectives—A 5-Year Survey
Authors: Pucci Resi , Cassoni Andrea , Di Carlo Daniele , Bartolucci Piero , Della Monaca Marco , Barbera Giorgio , Di Cosola Michele , Polimeni Antonella , Valentini Valentino
Published: February 2023

Background: Head and neck infections are commonly caused by affections with an odontogenic origin. Untreated or non-responsive to treatment odontogenic infections can cause severe consequences such as localized abscesses, deep neck infections (DNI), and mediastinitis, conditions where emergency procedures such as tracheostomy or cervicotomy could be needed. Methods: An epidemiological retrospective observational study was performed, and the objective of the investigation was to present a single-center 5-years retrospective analysis of all patients admitted to the emergency department of the hospital Policlinico Umberto I “Sapienza” with a diagnosis of odontogenic related head and neck infection, observing the epidemiological patterns, the management and the type of surgical procedure adopted to treat the affections. Results: Over a 5-year period, 376,940 patients entered the emergency room of Policlinico Umberto I, “Sapienza” University of Rome, for a total of 63,632 hospitalizations. A total of 6607 patients were registered with a diagnosis of odontogenic abscess (10.38%), 151 of the patients were hospitalized, 116 of them were surgically treated (76.8%), and 6 of them (3.9%) manifested critical conditions such as sepsis and mediastinitis. Conclusions: Even today, despite the improvement of dental health education, dental affections can certainly lead to acute conditions, necessitating immediate surgical intervention.
The Role of Preoperative Chronic Statin Therapy in Heart Transplant Receipts—A Retrospective Single-Center Cohort Study
Authors: Baba Dragos-Florin , Suciu Horatiu , Avram Calin , Danilesco Alina , Moldovan Diana Andreea , Rauta Radu Catalin , Huma Laurentiu , Sin Ileana Anca
Published: February 2023

Background: Statin therapy has been proven to reduce the risk of cardiovascular events. The objective of our retrospective study was to investigate the relationship between preoperative chronic administration of statins to postoperative 2-month heart transplantation complications. Methods: A total number of 38 heart transplantation recipients from the Cardiovascular and Transplant Emergency Institute of Târgu Mureș between May 2014 and January 2021 were included in our study. Results: In logistic regression, we found a statistical significance between statin treatment and the presence of postoperative complications of any cause (OR: 0.06, 95% CI: 0.008–0.56; p = 0.0128), simultaneously presenting an elevated risk for early-postoperative acute kidney injury (AKI). From the statin group, atorvastatin therapy had a higher risk of type 2 diabetes mellitus (T2DM) development (OR: 29.73, 95% CI: 1.19–741.76; p = 0.0387) and AKI (OR: 29.73, 95% CI: 1.19–741.76; p = 0.0387). C-reactive protein (CRP), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) represented risk factors, atorvastatin administration being independently associated with lower CRP values. Conclusions: Chronic previous administration of statins represented a protective factor to the development of 2-month postoperative complications of any cause in heart transplant receipts.
Association between Tai Chi Yuttari Exercise and Longevity and Prevention of Long-Term Care Need: Survival Analysis in Kitakata City, Japan
Authors: Moriyama Nobuaki , Kuga Tomomi , Oshima Tetsuzo , Sato Kumiko , Kurita Miho , Yasumura Seiji
Published: February 2023

This study examined whether participation in Tai Chi Yuttari exercise is associated with a delay in the death and new certification for long-term care need of older adults. Individuals who participated in Tai Chi Yuttari exercise classes in 2011–2015 (participation group) were compared with individuals from the Basic Resident Register of Kitakata City (non-participation group). Death and new certification for long-term care need were selected to evaluate the effectiveness of participation in Tai Chi Yuttari exercise classes. The periods from the start date of the observation to each person’s date of occurrence of events were calculated. The Kaplan–Meier method and log-rank test were used to compare survival curves between the groups. A total of 105 and 202 individuals in the participation and non-participation groups, respectively, were observed. Survival duration (χ2 = 8.782, p = 0.003) and the period before receiving certification for long-term care (χ2 = 5.354, p = 0.021) were longer in the participation group than in the non-participation group. In the stratified analysis by sex, survival duration was longer in the participation group in men only (χ2 = 7.875, p = 0.005). Participation in Tai Chi Yuttari exercise might be effective in delaying death, especially in men, and new certification for long-term care.
Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
Authors: Chandan Joht Singh , Brown Kirsty R. , Simms-Williams Nikita , Bashir Nasir Z. , Camaradou Jenny , Heining Dominic , Turner Grace M. , Rivera Samantha Cruz , Hotham Richard , Minhas Sonica , Nirantharakumar Krishnarajah , Sivan Manoj , Khunti Kamlesh , Raindi Devan , Marwaha Steven , Hughes Sarah E. , McMullan Christel , Marshall Tom , Calvert Melanie J. , Haroon Shamil , Aiyegbusi Olalekan Lee
Published: February 2023

Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treatments for PVS. Methods: We conducted a systematic review to evaluate the effectiveness of non-pharmacological interventions for PVS, as compared to either standard care, alternative non-pharmacological therapy, or placebo. The outcomes of interest were changes in symptoms, exercise capacity, quality of life (including mental health and wellbeing), and work capability. We searched five databases (Embase, MEDLINE, PsycINFO, CINAHL, MedRxiv) for randomised controlled trials (RCTs) published between 1 January 2001 to 29 October 2021. The relevant outcome data were extracted, the study quality was appraised using the Cochrane risk-of-bias tool, and the findings were synthesised narratively. Findings: Overall, five studies of five different interventions (Pilates, music therapy, telerehabilitation, resistance exercise, neuromodulation) met the inclusion criteria. Aside from music-based intervention, all other selected interventions demonstrated some support in the management of PVS in some patients. Interpretation: In this study, we observed a lack of robust evidence evaluating the non-pharmacological treatments for PVS, including Long COVID. Considering the prevalence of prolonged symptoms following acute viral infections, there is an urgent need for clinical trials evaluating the effectiveness and cost-effectiveness of non-pharmacological treatments for patients with PVS. Registration: The study protocol was registered with PROSPERO [CRD42021282074] in October 2021 and published in BMJ Open in 2022.
A Study of Urban Haze and Its Association with Cold Surge and Sea Breeze for Greater Bangkok
Authors: Aman Nishit , Manomaiphiboon Kasemsan , Pala-En Natchanok , Devkota Bikash , Inerb Muanfun , Kokkaew Eakkachai
Published: February 2023

This study deals with haze characteristics under the influence of the cold surge and sea breeze for Greater Bangkok (GBK) in 2017–2022, including haze intensity and duration, meteorological classification for haze, and the potential effects of secondary aerosols and biomass burning. A total of 38 haze episodes and 159 haze days were identified. The episode duration varies from a single day to up to 14 days, suggesting different pathways of its formation and evolution. Short-duration episodes of 1–2 days are the most frequent with 18 episodes, and the frequency of haze episodes decreases as the haze duration increases. The increase in complexity in the formation of relatively longer episodes is suggested by a relatively higher coefficient of variation for PM2.5. Four meteorology-based types of haze episodes were classified. Type I is caused by the arrival of the cold surge in GBK, which leads to the development of stagnant conditions favorable for haze formation. Type II is induced by sea breeze, which leads to the accumulation of air pollutants due to its local recirculation and development of the thermal internal boundary layer. Type III consists of the haze episodes caused by the synergetic effect of the cold surge and sea breeze while Type IV consists of short haze episodes that are not affected by either the cold surge or sea breeze. Type II is the most frequent (15 episodes), while Type III is the most persistent and most polluted haze type. The spread of haze or region of relatively higher aerosol optical depth outside GBK in Type III is potentially due to advection and dispersion, while that in Type IV is due to short 1-day episodes potentially affected by biomass burning. Due to cold surge, the coolest and driest weather condition is found under Type I, while Type II has the most humid condition and highest recirculation factor due to the highest average sea breeze duration and penetration. The precursor ratio method suggests the potential effect of secondary aerosols on 34% of the total haze episodes. Additionally, biomass burning is found to potentially affect half of the total episodes as suggested by the examination of back trajectories and fire hotspots. Based on these results, some policy implications and future work are also suggested.
How Does Internet Use Affect the Farmers’ Trust in Local Government: Evidence from China
Authors: Wei Suhao , Lu Yangxiao
Published: February 2023

The rapid spread of the internet in rural China in the 21st century has fundamentally reshaped the operation of the Chinese rural political system in ways that are at least as profound as television half a century ago. This study used the data of 8754 farmers from 2018 China Family Panel Studies (CFPS) in China to examine and provide empirical evidence on how internet use affects farmers’ trust in local government via a chain-mediation model. The results indicate that internet use erodes farmers’ trust in local government. Internet use is more likely to cause young and highly educated farmers to lose trust in local government. Both views on people’s livelihood problems and government performance evaluations play mediating roles between internet use and farmers’ trust in local government. Further, we also found that the negative direct impact of internet use on farmers’ trust in local government is also serial mediated by views on people’s livelihood problems and government performance evaluations. The results expand the research on the factors influencing trust in government.
Effect of Organic Compounds on the Special Properties and the Microstructure of Autoclaved Brick
Authors: Dachowski Ryszard , Stepien Anna
Published: February 2023

After a long decomposition process, organic matter turns into humic substances. In humus, carbon dioxide (CO2) bound in photosynthesis is brought back to the soil, where it should be used by its ecosystem. This is important because similar relationships are found in modern concretes and concretes designed with the use of geochemical modeling (possibility of the C-S-H phase for storing harmful substances). The aim of the article was to investigate the possibility of using humus (Humus Active-HA) and vermicompost (Biohumus Extra Universal-BEU), i.e., organic matter resulting from a long process of biological decomposition in the production of autoclaved bricks containing only ecological materials, i.e., sand, lime, and water. Tests of compressive strength, density, microstructure based on SEM, XRD, and micro-CT analysis were performed. The results of the research indicate that humus and vermicompost can be successfully used in their production. The paper compares traditional products and products made of raw material mass containing 3%, 7%, and 11% of humus and vermicompost, using the apparatus of mathematical experiment planning. Compressive strength, volumetric density, water absorption, and wicking, porosity, and material microstructure were tested. The best results were obtained for samples with the addition of 7% humus and 3% vermicompost. The compressive strength increased to 42.04 MPa (compared to standard bricks, whose strength is 15–20 MPa), and the bulk density increased by about 55%, to the value of 2.11 kg/dm3, which indicates the densification of the material’s microstructure. They were characterized by the highest compressive strength, moderate water absorption, and a high proportion of closed pores in the sample.
Impact of Environmental Uncertainties and Strategic Flexibility in Innovation Activities on NEV Battery Recycling Firms in China
Authors: Liu Jingxian , Wu Yingyu , Liu Lili
Published: February 2023

Due to the popularization and development of new energy vehicles (NEVs) worldwide, power batteries that have been used are being retired and replaced. In China’s battery recycling industry, the legal NEV battery recycling enterprises are at a negative financial performance. Based on theory of organizational adaptation, the key to innovation performance and sustainable development is recognition of the environment and strengthening organizational flexibility. This study empirically explores the bidirectional dynamic relationships among heterogeneous environmental uncertainties, innovation activities, firm growth and strategic flexibility in Chinese NEV battery recycling firms. A total of 1040 sample data were collected from 2015 to 2021. The research results demonstrate that environmental uncertainty (EU), strategic flexibility (SF) and innovation activities (INNO) all had impacts on firm growth (FG). Specifically, INNO had strongly negative effects in the short term, and in the long term, it will bring a positive effect to FG; the impact of EPU was more important than market uncertainty (MU) to FG and innovation activities. This could be due to the dependence of the Chinese NEV battery recycling industry on government policy. However, MU has a strong impact on SF. Moreover, the levels of SF should be reasonable, otherwise it could be a burden to enterprises. There also exists the bidirectional dynamic relationships between FG and INNO. This study contributes a non-core perspective to strategic flexibility research by revealing the complex environmental mechanism, and to the Chinese NEV battery recycling industry we provide a theoretical basis and practical guidance for government and firms on how to apply SF to promote innovation and realize growth in the present business environment.
Addressing Complex Social Problems Using the Lens of Family Violence: Valuable Learning from the First Year of an Interdisciplinary Community of Practice
Authors: Greville Heath , House William , Tarrant Stella , Thompson Sandra C.
Published: February 2023

It is imperative that universities continue to explore innovations that support staff and student learning and pursue their mission to promote social responsibility and community service. Communities of Practice have been used to facilitate innovation and regenerate teaching and learning in tertiary contexts, including interdisciplinary collaborations around complex problems. This study describes the challenges and achievements of the first year of an interdisciplinary Community of Practice which aimed to create innovative approaches to teaching and learning about family and domestic violence, a complex social issue, inherently gendered, which receives little attention across the University discipline areas, despite the centrality of this issue in much of the future work of University graduates within a range of professional areas. We interviewed engaged members to explore the value gained from their first year of involvement in the Community of Practice. This initiative brought members substantial value while recognising the need for long-term engagement and commitment from the senior University leadership to embed innovation. A key lesson was that developing an innovative curriculum to address critical and ongoing social and public health issues requires much more senior leadership, responsibilities shared across faculty, and commitment of dedicated resources and staff time. The findings provide valuable learning for other Communities of Practice attempting to engage with complex problems and create innovative interdisciplinary approaches to teaching, learning, and research.