bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of AVAZ Seismic Forward Modeling of Fracture-Cavity Reservoirs of the Dengying Formation, Central Sichuan Basin
Authors: Liu Yisheng , Zhu Zhengping , Pan Renfang , Gao Bole , Jin Jineng
Published: July 2022

For the purpose of clarifying the seismic response characteristics of fractured-cavity reservoirs of Dengying Formation in the central Sichuan Basin, the paper first intends to establish three geological models of fracture cave reservoirs based on drilling, logging, and core data of the Dengying Formation in the central Sichuan Basin. Then, the formation reflection is calculated with reference to anisotropic Horizontal Transverse Isotropy (HTI) medium. Finally, further research on Amplitude Variation with Azimuth (AVAZ) seismic forward modeling has been conducted to clarify the seismic response characteristics of different reservoir types in the study area. The results suggest that: Seismic response characteristics of fractured-cavity reservoirs are controlled by incident angle and azimuth angle of seismic waves in different types of reservoirs. The incident angle of the seismic wave controls the difference in amplitude caused by different micro-fracture densities, and the azimuth angle controls the identification ability of the micro-fracture direction. The increase in incident angle brings about a gradual decline in amplitude. The magnitude reaches the highest when the azimuth is parallel to the normal direction of the fracture surface; however, it’ll come down to the lowest as the azimuth is perpendicular to the normal direction of the fracture surface. The fracture density fails to affect the amplitude as long as the azimuth angle is parallel to the direction of the fracture. However, the decreased amplitude reflects the increasing fracture density as the azimuth angle is identical to the normal direction of the fracture surface. The comparison between the theoretical model of three different types of fractured-cavity reservoirs and the actual uphole trace shows that the model has high accuracy. The prospect of seismic identification of fractured-cavern reservoirs, based on the results, can provide us with feasible and applicable evidence for future research on seismic identification of reservoirs and prediction of fracture distribution in the Dengying Formation of central Sichuan.
Comparison of Different Topologies of Thermal Management Subsystems in Multi-Stack Fuel Cell Systems
Authors: Shen Wei , Fan Lei , Pan Zhirong , Chen Chunguang , Wang Ning , Zhou Su
Published: July 2022

The performance of a fuel cell stack is affected by the operating temperature of the stack. The thermal management subsystem of a multi-stack fuel cell system (MFCS) is particularly significant for the operating temperature control of each stack in the MFCS. To study the influence of different topologies of a MFCS thermal management subsystem, this paper proposes and establishes two different topologies. Firstly, the integrated topology is proposed. Secondly, seven component models, namely the mixer, thermostat, radiator, tank, pump, bypass value, and proton exchange membrane fuel cell stack temperature models, are described in detail. Finally, the performance of the two topologies of the MFCS thermal management subsystem under two working conditions, steady (200 A) and variable (China heavy-duty commercial test cycle, C-WTVC), is compared. Furthermore, there are two evaluating indicators, including the stability duration and deviation of the operating temperatures of the single stack in the MFCS. Results show that when the MFCS operates under steady working conditions, the integrated topology is superior in operating temperature control accuracy (ΔT<0.5 K), while the distributed topology is superior in the adjustment process (t ≤ 100 s). Moreover, when the MFCS operates under variable working conditions, the distributed topology is superior in operating temperature control accuracy.
Carbon Emission Trading and Corporate Financing: Evidence from China
Authors: Meng Li , Wang Ke , Su Taoyong , He He
Published: July 2022

As an important tool to control CO2 emission, carbon emission trading (CET) has been highlighted in prior studies for its positive effects on firms. However, we are concerned about the role of the CET in corporate financing. Through a quasi-natural experiment from China’s CET pilot, regarded as the start-up stage of China’s emission trading system, we investigate the manufacturing corporate financing (i.e., debt and commercial credit financing). The results show that the firms in China’s CET market have less debt financing. Additionally, in the heterogeneity analysis, we found that (1) the CET is negatively related to corporate financing when their financing constraints are weak, whereas it only reduces long-term debt for the firms with strong financing constraints. (2) The impact of the CET on corporate financing is not significant for the firms located in first-tier cities in China, but in other cities, the CET negatively influences firms’ long-term debt and contributes to commercial credit financing. (3) The CET only plays a negative role in long-term debt and a positive role in commercial credit financing for firms in high energy-consuming industries. This study enlightens the government to improve the emission trading system and increase financing support to manufacturing firms in the CET market.
Analysis of China’s Carbon Peak Achievement in 2025
Authors: Niu Ziheng , Xiong Jianliang , Ding Xuesong , Wu Yao
Published: July 2022

To solve the problem of rising energy use and CO2 emissions, China issued the 14th Five-Year Plan in 2020, emphasizing the need to reduce its carbon intensity and achieve a carbon emission peak before 2030. In order to estimate the future path of carbon peak in China, a novel dataset was constructed to analyze 30 provinces in China, and found that the realization of carbon peaking in 2025 requires a reduction of 1.072 million tons of carbon emissions in 2025, at which point peak carbon emissions will be 11,008.4 million tons. Due to this energy gap caused by carbon emission reduction the total amount of clean electricity has reached 3600 billion kWh. In carbon emission allowance trading, provinces with large carbon emissions, like Jiangsu and Guangdong, prefer to buy carbon allowances, while those with small carbon emissions like Shanxi and Inner Mongolia prefer to sell carbon allowances. In the energy trading market, the overall situation meets the 14th Five-Year Plan of west-east and north-south power transmission, except for Shanghai, Hainan, Hubei, and other provinces selling power, due to excessive power generation from a particular energy source.
Comparative Toxicity of Vegan Red, E124, and E120 Food Dyes on Three Rapidly Proliferating Model Systems
Authors: Avallone Bice , Arena Carmen , Simoniello Palma , Di Lorenzo Mariana , Vitale Ermenegilda , Capriello Teresa , Ferrandino Ida , Raggio Anja , Sasso Margherita , Napolitano Gaetana , De Bonis Salvatore , Fogliano Chiara , Agnisola Claudio , Motta Chiara Maria
Published: July 2022

The abuse of artificial food dyes and the evidence that they harm human health recently prompted a significant effort to introduce vegan substitutes prepared from fruits and vegetables. Not much information, however, has been collected on their possible effects on aquatic and terrestrial ecosystems once released as waste in surface waters. For this purpose, we analyzed the effects of a vegan red (VEG) preparation (concentration 1.2 g/L) on three rapidly proliferating models for terrestrial and aquatic ecosystem contamination. In particular, in vitro cells cultures (exposure for 24 h), Artemia salina nauplii and Cucumis sativus seedlings (exposure 5 days). A comparison was made with the effects exerted by the two dyes that vegan red is intended to replace: an animal dye, cochineal E120 and an artificial dye E124. The analyses of conventional endpoints, indicative of cell proliferation, differentiation, and growth rate, demonstrate that the three dyes affect development and that the vegan substitute is as unsafe as the E124 and E120. Vegan red in fact impairs cell growth in in vitro cells, delays naupliar hatching and early growth in Artemia, and reduces shoot/root biomass in Cucumis. Marked hyperplasia and hypertrophy of mesophyll are also observed in Cucumis leaves. Substitution in food and beverages, therefore, should be carefully reconsidered to avoid unnecessary environmental contamination.
Effects of Hydroxy-Alpha-Sanshool on Intestinal Metabolism in Insulin-Resistant Mice
Authors: Xu Fangyan , Zhu Yuping , Lu Mintao , Qin Likang , Zhao Degang , Ren Tingyuan
Published: July 2022

To explore the hydroxy-alpha-sanshool (HAS) effects on the intestinal metabolites of insulin-resistant mice, the blank group (BG), model group (MG), and HAS dose group (DG) were designed. The insulin resistance (IR) model was induced through streptozotocin (STZ) combined with a high-fat and high-sugar diet. Based on the availability of the model, the HAS dose was given by gavage for 28 days. The determination of cecum and key serum indexes was made, including the contents of insulin (INS), triglycerides (TG), total cholesterol (TC), glycosylated serum protein (GSP), and glycosylated hemoglobin (GHb). The changes in gut microbiota and metabolites in cecal contents were detected by 16S rRNA gene amplicon sequencing and UPLC/HRMS technology, respectively. The results that the levels of GSP, GHb, TG, and TC were significantly increased; this was not the case for INS; or for the changes in the gut microbiota and metabolites in MG. However, the intervention of HAS effectively reversed these changes, for instance, it decreased levels of GSP, GHb, TG, TC, and alterations of metabolite composition for linoleic acid and tyrosine metabolism and recovered trends of declining species diversity and richness of the gut microbiota in MG. It was indicated that HAS alleviated IR by regulating the gut microbiota and metabolites and affecting lipid and amino acid metabolism pathways.
MicrobiomeGWAS: A Tool for Identifying Host Genetic Variants Associated with Microbiome Composition
Authors: Hua Xing , Song Lei , Yu Guoqin , Vogtmann Emily , Goedert James J. , Abnet Christian C. , Landi Maria Teresa , Shi Jianxin
Published: July 2022

The microbiome is the collection of all microbial genes and can be investigated by sequencing highly variable regions of 16S ribosomal RNA (rRNA) genes. Evidence suggests that environmental factors and host genetics may interact to impact human microbiome composition. Identifying host genetic variants associated with human microbiome composition not only provides clues for characterizing microbiome variation but also helps to elucidate biological mechanisms of genetic associations, prioritize genetic variants, and improve genetic risk prediction. Since a microbiota functions as a community, it is best characterized by β diversity; that is, a pairwise distance matrix. We develop a statistical framework and a computationally efficient software package, microbiomeGWAS, for identifying host genetic variants associated with microbiome β diversity with or without interacting with an environmental factor. We show that the score statistics have positive skewness and kurtosis due to the dependent nature of the pairwise data, which makes p-value approximations based on asymptotic distributions unacceptably liberal. By correcting for skewness and kurtosis, we develop accurate p-value approximations, whose accuracy was verified by extensive simulations. We exemplify our methods by analyzing a set of 147 genotyped subjects with 16S rRNA microbiome profiles from non-malignant lung tissues. Correcting for skewness and kurtosis eliminated the dramatic deviation in the quantile–quantile plots. We provided preliminary evidence that six established lung cancer risk SNPs were collectively associated with microbiome composition for both unweighted (p = 0.0032) and weighted (p = 0.011) UniFrac distance matrices. In summary, our methods will facilitate analyzing large-scale genome-wide association studies of the human microbiome.
Spatiotemporal Pattern of Urban-Rural Integration Development and Its Driving Mechanism Analysis in Hangzhou Bay Urban Agglomeration
Authors: Xu Caiyao , Qian Chen , Yang Wencai , Li Bowei , Kong Lingqian , Kong Fanbin
Published: July 2022

The quantitative analysis of the urban-rural integration development (URID) level and its driving factors is of great significance for the new-type urbanization of urban agglomerations. This study constructed a multidimensional framework in the perspective of a population–space–economy–society–ecology framework to measure the URID level from 2000 to 2020 and further explored the driving mechanism of the URID changes by a geographical detector model in the Hangzhou Bay urban agglomeration (HBUA). The results showed that the land-use change in the HBUA from 2000 to 2020 showed a typical characteristic of the transition between cultivated and construction land. The URID level in the HBUA improved from 0.294 in 2000 to 0.563 in 2020, and the year 2005 may have been the inflection point of URID in the HBUA. The URID level showed a significant spatial aggregation with high values. Hangzhou, Jiaxing, and Ningbo were hot spots since 2015, and the cold spots were Huzhou and Shaoxing. The population and spatial integration had more important impacts on URID levels in 2000, 2005, and 2020, while economic and social integration had more significant impacts on URID levels in 2010 and 2015. This study provided a deeper understanding of the evolution of URID in an urban agglomeration and could be used as a reference for decision makers.
Targeted and Population-Wide Interventions Are Needed to Address the Persistent Burden of Anemia among Women of Reproductive Age in Tanzania
Authors: Sunguya Bruno F. , Ge Yue , Mlunde Linda B. , Mpembeni Rose , Leyna Germana H. , Poudel Krishna C. , Parekh Niyati , Huang Jiayan
Published: July 2022

Recent evidence suggests that 44.8% of women of reproductive age (WRA) in Tanzania suffer from anemia. Addressing this public health challenge calls for local evidence of its burden and determinants thereof for policy and tailored interventions. This secondary data analysis used Tanzania Demographic and Health Surveys (TDHS) 2004–2005 and 2015–2016 with a total of 23,203 WRA. Data were analyzed using descriptive statistics to characterize the burden of anemia, regression analyses to examine the adjusted change in the prevalence of anemia and remaining determinants thereof, and the Global Information System (GIS) to map the differences in the burden of anemia in Tanzania over the period of one decade. Considering the risk factors of anemia observed in our study, WRA in Tanzania should have been 15% less likely to suffer from anemia in 2015 compared to 2005. However, a small decline (3.6%) was not evenly distributed across the regions in Tanzania. Factors that remained significantly associated with anemia among WRA in the latest survey include age above 35 years (AOR = 1.564, p = 0.007), education level (AOR = 0.720, p = 0.001), pregnancy status (AOR = 1.973, p < 0.001), and use of contraception (AOR of 0.489, p < 0.001). Our findings suggest that WRA in Tanzania aged above 35 should be the target population to accept the more tailored interventions.
Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants
Authors: Kirk Andrea B. , Plasse Kelsey Marie , Kirk Karli C. , Martin Clyde F. , Ozsoy Gamze
Published: July 2022

PFASs have been detected in nearly every serum sample collected over the last two decades from US adults as part of the National Health and Nutrition Examination Survey (NHANES) and are commonly found in other data sets from around the world. However, less is known about infant PFAS exposures, primarily because the collection of infant serum samples is less common and frequently avoided. Cord blood samples are often preferred for chemical exposure assessments because this is thought to provide a good representation of infant serum concentrations, at least at the time of birth. In this paper, we will provide a statistical and probabilistic analysis of what can be expected for infants living in the US using NHANES from 2007 to 2008, which contains a rare subset of infant data. Regulatory efforts that require estimation of exposures among the very youth can be challenging, both because of a lack of data in general and because variability among this most vulnerable population can be uncertain. We report that US infant exposures are extremely common and that serum concentrations remain fairly constant, despite infant growth rates and relatively high caloric and fluid intake, with the possible exception of PFOS. Infant serum PFOS concentrations between months 1 and 3 are consistently higher than at less than one month, even though healthy infants at 1 and 2 months weigh more than they did at birth. This suggests that the babies are exposed to greater concentrations of PFOS after birth or that excretion kinetics differ for this PFAS.
Relationship between Fatigue and Self-Perception of Constipation in Community-Dwelling Older Adults during the COVID-19 Pandemic
Authors: Hayashi Chisato
Published: July 2022

Fatigue and constipation are common symptoms among community-dwelling older adults; however, no studies have explored the relationship between both symptoms in said group. Therefore, this study aimed to examine the relationship between fatigue and self-perception of constipation in community-dwelling older adults during the COVID-19 pandemic. A cross-sectional survey was conducted among 97 older people (response rate: 73.2%) between July and November 2021. Backward–forward stepwise linear regression was performed to identify possible predictors of fatigue among the explanatory variable (self-perception of constipation) and possible confounders, which included (a) age, (b) motor fitness scale, (c) economic satisfaction, (d) subjective memory impairment, (e) subjective health, (f) depression, (g) living alone or not, (h) sex, and (i) frequency of exercise. The intercept of the fatigue score was 42.48 points (95% CI = 32.40 to 49.99, p < 0.001). The results showed that the fatigue score in community-dwelling older adults who had self-perception of constipation was significantly lower (i.e., they had higher fatigue; B = −4.49, 95% CI = −6.58 to −2.40, p < 0.001) compared to those who did not have self-perception of constipation. Therefore, there is a need to develop self-management strategies that older people can use to improve the self-perception of constipation.
Investigating the Difference in Factors Contributing to the Likelihood of Motorcyclist Fatalities in Single Motorcycle and Multiple Vehicle Crashes
Authors: Wang Ming-Heng
Published: July 2022

In order to better understand the factors affecting the likelihood of motorcyclists’ fatal injuries, motorcycle-involved crashes were investigated based on the involvement of the following vehicles: single motorcycle (SM), multiple motorcycles (MM) and motorcycle versus vehicle (MV) crashes. Method: Binary logit and mixed logit models that consider the heterogeneity of parameters were applied to identify the critical factors that increase the likelihood of motorcyclist fatality. Results: Mixed logit models were found to have better fitting performances. Factors that increase the likelihood of motorcyclist fatality include lanes separated by traffic islands, male motorcyclists, and riding with BAC values of less than the legally limited value. Collisions with trees or utility poles lead to the highest likelihood of fatality in SM crashes. The effects of curved roads, same-direction swipe crashes, youth, and unlicensed motorcyclists are only significant in the likelihood of fatality in SM crashes. Conclusions: Motorcyclists tend to be killed if they collide with large engine-size motorcycles and vehicles, unlicensed motorcyclists, or drivers with speeding related or right-of-way violations with positive BAC values. Driving or riding should be prohibited for any amount of alcohol or for anyone with a positive BAC value. Law enforcement should focus on unlicensed, speeding motorcyclists and drivers, and those who violate the right of way or perform improper turns. Roadside objects and facilities should be checked for appropriate placement and be equipped with reflective devices or injury protection facilities.
Social Marketing Strategy to Promote Traditional Thai Medicines during COVID-19: KAP and DoI Two-Step Theory Application Process
Authors: Senachai Prarawan , Julsrigival Jakaphun , Sann Raksmey
Published: July 2022

Introduction: Recently, the Thai government has been promoting the innovation of finished forms of traditional Thai medicine (TTM) products (e.g., tablets and capsules). According to the existing literature, most consumers are unaware of the finished forms of TTMs because of conflicting knowledge, information, and communication. Therefore, the consumers have poor perceptions about TTMs and their benefits. Purpose: This qualitative study explores the current perceptions about TTMs and the modes of promotion that are being utilized to develop a strategic communication plan for the finished forms of TTMs. Design/methodology/approach: Utilising thematic analysis, focus groups were conducted with thirty experienced consumers. Findings: Using KAP and DoI theory, the following three themes emerged in this study: (i) the current KAP of Thai consumers toward the finished forms of TTM; (ii) factors influencing the use of finished forms of TTM; and (iii) integrated marketing communication as a promotion strategy to rapidly disseminate knowledge. Research limitations/implications: Given Thailand’s large population, the findings of this study are substantially limited and cannot be generalized. Therefore, the findings herein may not reflect the experiences and opinions of the Thai consumers residing in other regions or the opinions of the entire country. Originality/value: This study utilises interdisciplinary methods and two-step theory application to explain the current knowledge and perceptions about the finished forms of TTM and develop proper communication and media strategies that can promote the finished forms of traditional Thai medicines, helping to widen their usage significantly.
Social Undermining and Interpersonal Rumination among Employees: The Mediating Role of Being the Subject of Envy and the Moderating Role of Social Support
Authors: Song Ying , Zhao Zhenzhi
Published: July 2022

Rumination is a common problem and is associated with reduced psychological well-being. However, little is known about how rumination in the workplace is affected by interpersonal relationships. We propose that negative workplace behavior could serve as a potential influencing factor for rumination. Therefore, the current study constructed a multilevel moderated mediation model to investigate the relationship between workplace unit social undermining and interpersonal rumination. We also examined whether unit social support moderated that relationship and whether being the subject of envy mediated that relationship. Survey data were collected from 630 employees in China. The results indicate that: (1) a high level of unit social undermining by either a supervisor or co-workers has a significant positive influence on interpersonal rumination; (2) being the subject of envy exerts a mediating effect between unit supervisor social undermining and interpersonal rumination, as well as between unit co-worker social undermining and interpersonal rumination; and (3) unit social support moderates the associations between unit supervisor/co-worker social undermining and interpersonal rumination. These findings extend the research on rumination to the field of management and interpersonal relationships and emphasize the potential mechanisms of rumination, providing significant guidance for reducing staff rumination and improving psychological well-being.
Analysis of Representations of the Aid That Public Psychological Support Points Provide to Adolescent Female Victims of Gender-Based Violence: Reformulation of Policies and Practices
Authors: Cuadrado-Gordillo Isabel , Martín-Mora-Parra Guadalupe , Puig-Amores Ismael
Published: July 2022

Gender-based violence in adolescence has become a social health problem that is creating great concern and interest worldwide. In this regard, knowledge of the role taken by the professionals responsible for screening, detecting, referring, and caring for adolescent victims is essential to be able to understand the phenomenon and its characteristics in a practical way. In this sense, psychologists specialising in the care of victims of adolescent gender-based violence have complete and in-depth knowledge, not only of the phenomenon itself and the way in which it is presented in society, but also of the features presented by these victims and the aspects that need to be worked on during the intervention process. Given this context, a series of interviews with psychologists specialised in the care of gender-based violence victims were subjected to a qualitative deductive/inductive analysis. These interviews addressed the psychologists’ theoretical-practical knowledge about the adolescent gender-based violence phenomenon. The analysis of the results points to the victims’ irrational ideas regarding abusive relationships, to the form in which Psychological Support Points are organised to help the victims, and to the strengths, weaknesses, and needs of these centres for them to be able to improve their operation and effectiveness in providing comprehensive care for adolescents beyond the psychological consultations themselves.
Paramedics in Switzerland: A Mature Profession
Authors: Schmutz Thomas , Guechi Youcef , Denereaz Sandrine , Ozainne Florian , Nuoffer Marc , Exadaktylos Aris , Ribordy Vincent
Published: July 2022

This paper describes how the profession of paramedics has evolved in Switzerland and takes the perspective of public health. Ambulance drivers play an important role in the health system, not only as a response to emergencies, but also by working in an interprofessional and interdisciplinary manner in response to other public health needs, such as home care, triage, telemedicine and interhospital transfers. This pre-hospital system is rapidly evolving and relies on the work of paramedics.
Recent Trends in Health Literacy Research, Health Status of the Population and Disease Prevention: An Editorial
Authors: Barańska Agnieszka , Kłak Anna
Published: July 2022

One challenge for the development of healthcare systems worldwide is to shape society’s health literacy [...]
Transition to Motherhood of Mothers Receiving Continuity of Child-Rearing Support
Authors: Itai Mai , Harada Shizuka , Nakazato Ryoko , Sakurai Shinobu
Published: July 2022

Clarifying the transition to motherhood based on the experience of mothers receiving continuity of child-rearing support is expected to promote the transition, and enhance nursing support. This study clarifies the transition process by which mothers recognize and adapt to new roles with continuity of child-rearing support in Japan. Semi-structured interviews were conducted with 13 mothers who received continuity of child-rearing support. Directed content analysis based on Meleis’s Transition Theory was used to analyze the results and define a framework for analyzing the transition. A theoretical framework was identified based on the Transition Theory themes. Engagement in terms of proactive involvement in pregnancy, childbirth, and child-rearing was a transition property. Maintaining the mother’s well-being, building new relationships and connections, and reflecting on child-rearing in the community were transition conditions. For patterns of response, the process indicators comprised having a sense of connection with the community and reflecting on one’s child-rearing objectively. Increased readiness for child-rearing and identity re-shaping were outcome indicators. The results suggest that it is important to enhance mothers’ readiness for child-rearing for transition to motherhood, and to promote the reshaping of their identities through continuity of support from pregnancy to postpartum child-rearing.
Supervised Learning Models for the Preliminary Detection of COVID-19 in Patients Using Demographic and Epidemiological Parameters
Authors: Pradhan Aditya , Prabhu Srikanth , Chadaga Krishnaraj , Sengupta Saptarshi , Nath Gopal
Published: July 2022

The World Health Organization labelled the new COVID-19 breakout a public health crisis of worldwide concern on 30 January 2020, and it was named the new global pandemic in March 2020. It has had catastrophic consequences on the world economy and well-being of people and has put a tremendous strain on already-scarce healthcare systems globally, particularly in underdeveloped countries. Over 11 billion vaccine doses have already been administered worldwide, and the benefits of these vaccinations will take some time to appear. Today, the only practical approach to diagnosing COVID-19 is through the RT-PCR and RAT tests, which have sometimes been known to give unreliable results. Timely diagnosis and implementation of precautionary measures will likely improve the survival outcome and decrease the fatality rates. In this study, we propose an innovative way to predict COVID-19 with the help of alternative non-clinical methods such as supervised machine learning models to identify the patients at risk based on their characteristic parameters and underlying comorbidities. Medical records of patients from Mexico admitted between 23 January 2020 and 26 March 2022, were chosen for this purpose. Among several supervised machine learning approaches tested, the XGBoost model achieved the best results with an accuracy of 92%. It is an easy, non-invasive, inexpensive, instant and accurate way of forecasting those at risk of contracting the virus. However, it is pretty early to deduce that this method can be used as an alternative in the clinical diagnosis of coronavirus cases.
Synthesis and Crystal Structures of Mn(II) and Co(II) Complexes as Catalysts for Oxidation of Cyclohexanone
Authors: Tella Adedibu C. , Isaac Aaron Y. , Clayton Hadley S. , Ogunlaja Adeniyi S. , Venugopalan Aswathy T. , Prabu Marimuthu , Thirumalaiswamy Raja
Published: July 2022

The global demand on adipic usage in the production of plasticizers and synthetic polyamide is increasing. In line with the search for an efficient and energy-conserving way to isolate adipic acid (AA) in good yields, this paper introduces the oxidization of cyclohexanone utilizing two new coordination compounds, [Mn(2,6-pydc)2](imi) (1) and [Co(H2pza)2(H2O)2(NO3)].NO3 (2), as catalysts. Compounds 1 and 2 were synthesized by room temperature and refluxing methods, and characterized by spectral analyses (IR and UV-Vis.), SEM, BET, TGA, elemental, and X-ray crystallography. The single crystal structure of compound 1 revealed that pyridinedicarboxylate (2,6-pydc) and imidazole (imi) moieties were coordinated to the Mn(II) atom through imine nitrogen and deprotonated oxygen atoms, to form an undistorted octahedral coordination geometry with the N2O4 donor set. The axial and equatorial planes containing O2, O4, O5, and O7 atoms were from two adjacent 2,6-pydc ligands which formed the unidendate donor ligand; imi, on the other hand, acted as a bidendate donor ligand. For compound 2, the Co(II) atom was being coordinated by two pyrazinamide (H2pza) moieties, which acted as an unidendate donor ligand; two water molecules occupying the axial position, and one nitrate molecule occupying the apical position, were within the coordination sphere; a nitrate molecule was disordered outside the coordination sphere. The distance, 4.658 Å, between the Co1 atom and the N8 atom of the uncoordinated nitrate molecule, was within the range reported elsewhere. Cyclohexanone peroxidation experiments revealed that compound 1 exhibited unique catalytic performance by giving a 72.8% yield in adipic acid, in comparison to the 71.3% yield obtained with compound 2. The yields in AA were maintained by way of recyclability evaluation. The reaction kinetics of compound 2 gave less activation energy, Ea 2938 J mol−1, while the thermodynamic parameters indicated that the chemical reactivity of cyclohexanone on the active surfaces of compounds 1 and 2 was via monolayer physisorption.
The Effects of Active Video Game Exercise Based on Self-Determination Theory on Physical Fitness and Cognitive Function in Older Adults
Authors: Zhao Chenglei , Zhao Chenxi , Li Yunfeng , Zhao Minmin , Wang Lin , Guo Jiawei , Zhang Longhai , Sun Yuliang , Ye Xintong , Zhu Wenfei
Published: July 2022

Background: Aging and physical inactivity are associated with declines in physical fitness and cognitive function. Active video games have proven to be beneficial for the physical health of older adults, but the exact effect of active video games on physical fitness and cognitive function was still unclear. Based on self-determination theory (SDT), which is a widely used theory of healthy behavior change, this study aimed to explore the effects of an active video game intervention on fitness and cognitive function in older adults. Methods: A total of 38 participants (mean age = 65.68 ± 3.78 years, 24 female) were randomly assigned to either an intervention group (active video game training) or a control group (no additional intervention). The participants in the intervention group trained for a total of 36 sessions (3 times per week for 50–55 min each) for 12 weeks. The control group continued with their normal daily living. The pre- and posttest measurements included: IPAQ-C score and physical fitness (BMI, body fat percent, blood pressure, reaction time, sit and reach, vital capacity, grip strength, static balance, blood biochemical tests for liver function, kidney function, blood lipids, glucose and insulin levels) and cognitive functions (processing speed, spatial ability, working memory, language ability, associative memory). Result: The intervention group showed a significantly smaller decrease in total average physical activity relative to the control group. BMI, vital capacity, systolic blood pressure, diastolic blood pressure, and spatial cognition significantly improved after training in the intervention group (BMI: F = 9.814, p = 0.004, d = −0.93, vital capacity: F = 4.708, p = 0.038, d = 0.67, systolic blood pressure: F = 5.28, p = 0.028, d = −0.68, diastolic blood pressure: F = 6.418, p = 0.016, d = −0.86, spatial cognition: F = 8.261, p = 0.007, d = 0.72). Three measures of static balance (closed eyes) also showed improvements after training (total length of swing: F = 3.728, d = −0.62, total velocity of swing: F = 3.740, d = −0.62, total area of swing: F = 2.920, d = −0.70). No significant training effects were evident in the results from the blood biochemical tests. Conclusion: This study indicates a positive influence of active video game training on physical fitness and cognitive function. The use of SDT-based active video game exercise as a feasible, safe, and effective training method for improving community older adults’ healthy, promoting group cohesion, and increasing motivation to exercise.
Fertility Counseling in BRCA1/2-Mutated Women with Breast Cancer and Healthy Individuals
Authors: Kufel-Grabowska Joanna , Podolak Amira , Maliszewski Daniel , Bartoszkiewicz Mikołaj , Ramlau Rodryg , Lukaszuk Krzysztof
Published: July 2022

Breast cancer is the most commonly diagnosed cancer worldwide and the fifth leading cause of cancer death. In 2020, there were 2.3 million new cases, and 685,000 women died from it. Breast cancer among young women under 40 years of age accounts for 5% to 10% of all cases of this cancer. The greater availability of multi-gene sequence analysis by next-generation sequencing has improved diagnosis and, consequently, the possibility of using appropriate therapeutic approaches in BRCA1/2 gene mutation carriers. Treatment of young breast cancer patients affects their reproductive potential by reducing ovarian reserve. It can lead to reversible or permanent premature menopause, decreased libido, and other symptoms of sex hormone deficiency. This requires that, in addition to oncological treatment, patients are offered genetic counseling, oncofertility, psychological assistance, and sexological counseling. Given the number of BRCA1/2 gene mutation carriers among young breast cancer patients, but also thanks to growing public awareness, among their healthy family members planning offspring, the possibility of benefiting from preimplantation testing and performing cancer-risk-reduction procedures: RRM (risk-reducing mastectomy) and RRSO (risk-reducing salpingo-oophorectomy) significantly increase the chance of a genetically burdened person living a healthy life and giving birth to a child not burdened by the parent’s germline mutation. The goal of this paper is to show methods and examples of fertility counselling for BRCA1/2 gene mutation carriers, including both patients already affected by cancer and healthy individuals.
Cybersecurity Threats and Their Mitigation Approaches Using Machine Learning—A Review
Authors: Ahsan Mostofa , Nygard Kendall E. , Gomes Rahul , Chowdhury Md Minhaz , Rifat Nafiz , Connolly Jayden F
Published: July 2022

Machine learning is of rising importance in cybersecurity. The primary objective of applying machine learning in cybersecurity is to make the process of malware detection more actionable, scalable and effective than traditional approaches, which require human intervention. The cybersecurity domain involves machine learning challenges that require efficient methodical and theoretical handling. Several machine learning and statistical methods, such as deep learning, support vector machines and Bayesian classification, among others, have proven effective in mitigating cyber-attacks. The detection of hidden trends and insights from network data and building of a corresponding data-driven machine learning model to prevent these attacks is vital to design intelligent security systems. In this survey, the focus is on the machine learning techniques that have been implemented on cybersecurity data to make these systems secure. Existing cybersecurity threats and how machine learning techniques have been used to mitigate these threats have been discussed. The shortcomings of these state-of-the-art models and how attack patterns have evolved over the past decade have also been presented. Our goal is to assess how effective these machine learning techniques are against the ever-increasing threat of malware that plagues our online community.
An Automated Framework Based on Deep Learning for Shark Recognition
Authors: Le Nhat Anh , Moon Jucheol , Lowe Christopher G. , Kim Hyun-Il , Choi Sang-Il
Published: July 2022

The recent progress in deep learning has given rise to a non-invasive and effective approach for animal biometrics. These modern techniques allow researchers to track animal individuals on a large-scale image database. Typical approaches are suited to a closed-set recognition problem, which is to identify images of known objects only. However, such approaches are not scalable because they mis-classify images of unknown objects. To recognize the images of unknown objects as ‘unknown’, a framework should be able to deal with the open set recognition scenario. This paper proposes a fully automatic, vision-based identification framework capable of recognizing shark individuals including those that are unknown. The framework first detects and extracts the shark from the original image. After that, we develop a deep network to transform the extracted image to an embedding vector in latent space. The proposed network consists of the Visual Geometry Group-UNet (VGG-UNet) and a modified Visual Geometry Group-16 (VGG-16) network. The VGG-UNet is utilized to detect shark bodies, and the modified VGG-16 is used to learn embeddings of shark individuals. For the recognition task, our framework learns a decision boundary using a one-class support vector machine (OSVM) for each shark included in the training phase using a few embedding vectors belonging to them, then it determines whether a new shark image is recognized as belonging to a known shark individual. Our proposed network can recognize shark individuals with high accuracy and can effectively deal with the open set recognition problem with shark images.
A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients
Authors: Valentini Virginia , Silvestri Valentina , Bucalo Agostino , Marraffa Federica , Risicato Maria , Grassi Sara , Pellacani Giovanni , Ottini Laura , Richetta Antonio Giovanni
Published: July 2022

Cardiovascular disease (CVD) is one of the most common comorbidities that may affect psoriatic patients. Several exogenous and endogenous factors are involved in the etiology and progression of both psoriasis and CVD. A potential genetic link between the two diseases has emerged; however, some gaps remain in the understanding of the CVD prevalence in psoriatic patients. Recently, the role of the gut microbiome dysbiosis was documented in the development and maintenance of both diseases. To investigate whether gut microbiome dysbiosis might influence the occurrence of CVD in psoriatic patients, 16S rRNA gene sequencing was performed to characterize the gut microbiome of 28 psoriatic patients, including 17 patients with and 11 without CVD. The comparison of the gut microbiome composition between patients with and without CVD showed a higher prevalence of Barnesiellaceae and Phascolarctobacterium in patients with CVD. Among patients with CVD, those undergoing biologic therapy had lower abundance levels of Barnesiellaceae, comparable to those found in patients without CVD. Overall, these findings suggest that the co-occurrence of psoriasis and CVD might be linked to gut microbiome dysbiosis and that therapeutic strategies could help to restore the intestinal symbiosis, potentially improving the clinical management of psoriasis and its associated comorbidities.
COVID-19, Mucormycosis and Cancer: The Triple Threat—Hypothesis or Reality?
Authors: Mahajan Ishika , Ghose Aruni , Gupta Deepika , Manasvi Manasi , Bhandari Saisha , Das Aparimita , Sanchez Elisabet , Boussios Stergios
Published: July 2022

COVID-19 has been responsible for widespread morbidity and mortality worldwide. Invasive mucormycosis has death rates scaling 80%. India, one of the countries hit worst by the pandemic, is also a hotbed with the highest death rates for mucormycosis. Cancer, a ubiquitously present menace, also contributes to higher case fatality rates. All three entities studied here are individual, massive healthcare threats. The danger of one disease predisposing to the other, the poor performance status of patients with all three diseases, the impact of therapeutics for one disease on the pathology and therapy of the others all warrant physicians having a better understanding of the interplay. This is imperative so as to effectively establish control over the individual patient and population health. It is important to understand the interactions to effectively manage all three entities together to reduce overall morbidity. In this review article, we search for an inter-relationship between the COVID-19 pandemic, emerging mucormycosis, and the global giant, cancer.
The Role of Plasma Interleukin-6 Levels on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk Scores in Javanese Patients with Chronic Kidney Disease
Authors: Susilo Hendri , Thaha Mochammad , Pikir Budi Susetyo , Alsagaff Mochamad Yusuf , Suryantoro Satriyo Dwi , Wungu Citrawati Dyah Kencono , Pratama Nando Reza , Pakpahan Cennikon , Oceandy Delvac
Published: July 2022

Interleukin-6 (IL-6) has been identified as an important pro-inflammatory factor involved in mediating the severity of chronic kidney disease (CKD). This study sought to determine the effect of plasma IL-6 levels on atherosclerotic cardiovascular disease (ASCVD) and cardiovascular mortality risk scores in Javanese CKD patients. We also analyzed the frequency of IL-6 G174C single nucleotide polymorphism (SNP) in the population. This study was a cross-sectional study involving seventy-three patients of Javanese ethnic origin with stable chronic kidney disease. We assessed the ASCVD risk score, cardiovascular mortality score, genotyping of IL-6 G174C SNP, and plasma IL-6 levels in these patients. The genotype distribution and allele frequencies of the IL-6 G174C SNP were predominated by the G genotype/allele (GG: 97.26%, GC: 1.37%, CC: 1.37%, G-allele: 97.95%, and C-allele: 2.05%). Despite the fact that plasma IL-6 levels did not directly affect cardiovascular mortality risk, further analysis revealed its direct effect on the ASCVD risk score (path coefficient = 0.184, p = 0.043, 95% CI = 0.018–0.380), which in turn affected cardiovascular mortality risk (path coefficient = 0.851, p = <0.01, 95% CI = 0.714–0.925). In conclusion, plasma IL-6 levels play important roles on ASCVD risk and cardiovascular mortality risk in Javanese patients with CKD.
Retrograde Intramedullary Kirschner Wire Fixation as an Alternative for Treating Distal Fibular Shaft Fractures Combined with Distal Tibial Pilon Fractures
Authors: Huang Cheng-Wei , Wu Wen-Tien , Yu Tsai-Chiu , Chen Ing-Ho , Wang Jen-Hung , Yeh Kuang-Ting
Published: July 2022

Treatment or management techniques for pilon fractures are associated with high complication rates and poor outcomes. No consensus exists regarding the optimal surgical option for pilon fractures, especially for pilon fractures combined with distal fibular fractures. Accordingly, we explored the use of fibular fixation for treating pilon fractures involving distal fibular shaft fractures. We hypothesized that retrograde intramedullary Kirschner wire (K-wire) fixation is a suitable alternative technique for distal fibular fixation. We retrospectively reviewed the data of 156 patients who underwent surgery for pilon fractures at our hospital from May 2013 to May 2021. The radiographic and functional outcomes were comparable between the fibular intramedullary nailing (Group A; n = 80) and the fibular plating (Group B; n = 76) groups. Groups A and B differed significantly in total hospitalization time (11.4 vs. 18.2 days, p = 0.024), length of postoperative admission (6.8 vs. 11.4 days, p = 0.012), and total admission cost (USD 3624 vs. USD 6145, p = 0.004). We also noted that poor Olerud and Molander ankle scores were significantly associated with age (p = 0.008), smoking (p = 0.012), and preoperative admission length (p = 0.018). Retrograde intramedullary K-wire fixation produced a comparable 12-month functional outcome to plate fixation for distal fibular shaft fractures, rendering it a viable alternative method based on soft tissue condition.