bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia
Authors: Mancilla-Agrono Lorys Y. , Banguero-Micolta Lizeth F. , Ossa-López Paula A. , Ramírez-Chaves Héctor E. , Castaño-Villa Gabriel J. , Rivera-Páez Fredy A.
Published: December 2022

The genus Borrelia encompasses spirochetal species that are part of three well-defined groups. Two of these groups contain pathogens that affect humans: the group causing Lyme disease (LDG) and the relapsing fever group (RFG). Lyme disease is caused by Borrelia burgdorferi s.l., which is distributed in the Northern Hemisphere, and relapsing fevers are caused by Borrelia spp., which are found in temperate and tropical countries and are an emerging but neglected pathogens. In some departments of Colombia, there are records of the presence of Borrelia sp. in humans and bats. However, little is known about the impact and circulation of Borrelia spp. in the country, especially in wildlife, which can act as a reservoir and/or amplifying host. In this context, the objective of our research was to detect and identify the Borrelia species present in wild mammals in the departments of Caldas and Risaralda in Colombia. For morphological detection, blood smears and organ imprints were performed, and molecular identification was carried out through a nested PCR directed on the flagellin B (flaB) gene. A total of 105 mammals belonging to three orders (Chiroptera, Didelphimorphia and Rodentia) were analyzed, of which 15.24% (n = 16) were positive for Borrelia. Molecularly, the presence of Borrelia burgdorferi s.s. in lung tissues of Thomasomys aureus and blood of Mus musculus (Rodentia) was detected, with 99.64 and 100% identity, respectively. Borrelia sp. genospecies from a clade branch of a bat-associated LDG sister group were identified in seven individuals of bat species, such as Artibeus lituratus, Carollia brevicauda, Sturnira erythromos, and Glossophaga soricina. Furthermore, two Borrelia genospecies from the RFG in seven individuals of bats (A. lituratus, Artibeus jamaicensis, Platyrrhinus helleri, Mesophylla macconnelli, Rhynchonycteris naso) and rodents (Coendou rufescens, Microryzomys altissimus) were documented. Additionally, the presence of a spirochete was detected by microscopy in the liver of a Sturnira erythromos bat specimen. These results contain the first molecular evidence of the presence of B. burgdorferi s.s. in South America, which merits the need for comprehensive studies involving arthropods and vertebrates (including humans) in other departments of Colombia, as well as neighboring countries, to understand the current status of the circulation of Borrelia spp. in South America.
Clinical-Epidemiological Characteristics and Outcomes of Latent Tuberculosis Treatment at a Tertiary Center in Central-West Brazil from 2017 to 2019
Authors: Borges Moara Alves Santa Bárbara , Cunha Iago Dib , Candini Luís Henrique , de Souza Vitor Alves , da Costa Paulo Sérgio Sucasas
Published: December 2022

Detailed information concerning latent tuberculosis infection (LTBI) and treatment outcomes is scarce in Brazil. This retrospective cross-sectional study aimed to describe LTB treatment (LTBT) at a tertiary center in Central-West Brazil from 2017 to 2019. We recommended the use of LTBTs before the implementation of a rifapentine-isoniazid (3HP) regimen in Brazil. We conducted a descriptive analysis using chi-square or t-tests to assess differences in the proportions and means. Of 79 notified adult patients (males, 68%; median age, 40 (interquartile range, 30–51) years), most people were living with human immunodeficiency virus (PLHIV) (82%) or receiving immunosuppressant medication (15%), and 92% were receiving their first treatment. Isoniazid (INH) for 6–9 months had previously been proposed for 95% of the patients, with only 35% completeness. Four patients treated with rifampicin (4RMP) completed the regimen (p = 0.009). Adverse events occurred in 19% of the patients. In this Brazilian tertiary center, the target population for LTBT were young PLHIV patients under immunosuppression with low education levels. However, the INH monotherapy dropout rate was 65%. Therefore, shorter courses, such as 3HP and 4RMP, are promising alternatives. Behavioral aspects, education level, and regimen length can influence the course completion, and further studies are required to evaluate the 3HP regime in Brazil.
Downregulation of the Protein C Signaling System Is Associated with COVID-19 Hypercoagulability—A Single-Cell Transcriptomics Analysis
Authors: Silva Bruna Rafaela Santos , Jara Carlos Poblete , Sidarta-Oliveira Davi , Velloso Licio A. , Velander William H. , Araújo Eliana P.
Published: December 2022

Because of the interface between coagulation and the immune response, it is expected that COVID-19-associated coagulopathy occurs via activated protein C signaling. The objective was to explore putative changes in the expression of the protein C signaling network in the liver, peripheral blood mononuclear cells, and nasal epithelium of patients with COVID-19. Single-cell RNA-sequencing data from patients with COVID-19 and healthy subjects were obtained from the COVID-19 Cell Atlas database. A functional protein–protein interaction network was constructed for the protein C gene. Patients with COVID-19 showed downregulation of protein C and components of the downstream protein C signaling cascade. The percentage of hepatocytes expressing protein C was lower. Part of the liver cell clusters expressing protein C presented increased expression of ACE2. In PBMC, there was increased ACE2, inflammatory, and pro-coagulation transcripts. In the nasal epithelium, PROC, ACE2, and PROS1 were expressed by the ciliated cell cluster, revealing co-expression of ACE-2 with transcripts encoding proteins belonging to the coagulation and immune system interface. Finally, there was upregulation of coagulation factor 3 transcript in the liver and PBMC. Protein C could play a mechanistic role in the hypercoagulability syndrome affecting patients with severe COVID-19.
In Vitro and Pre-Clinical Evaluation of Locally Isolated Phages, vB_Pae_SMP1 and vB_Pae_SMP5, Formulated as Hydrogels against Carbapenem-Resistant Pseudomonas aeruginosa
Authors: S. Mabrouk Samar S. , Abdellatif Ghada R. , Abu Zaid Ahmed S. , Aziz Ramy K. , Aboshanab Khaled M.
Published: December 2022

The inadequate therapeutic opportunities associated with carbapenem-resistant Pseudomonas aeruginosa (CRPA) clinical isolates impose a search for innovative strategies. Therefore, our study aimed to characterize and evaluate two locally isolated phages formulated in a hydrogel, both in vitro and in vivo, against CRPA clinical isolates. The two phages were characterized by genomic, microscopic, phenotypic characterization, genomic analysis, in vitro and in vivo analysis in a Pseudomonas aeruginosa-infected skin thermal injury rat model. The two siphoviruses belong to class Caudovirectes and were named vB_Pae_SMP1 and vB_Pae_SMP5. Each phage had an icosahedral head of 60 ± 5 nm and a flexible, non-contractile tail of 170 ± 5 nm long, while vB_Pae_SMP5 had an additional base plate containing a 35 nm fiber observed at the end of the tail. The hydrogel was prepared by mixing 5% w/v carboxymethylcellulose (CMC) into the CRPA propagated phage lysate containing phage titer 108 PFU/mL, pH of 7.7, and a spreadability coefficient of 25. The groups were treated with either Phage vB_Pae_SMP1, vB_Pae_SMP5, or a two-phage cocktail hydrogel cellular subepidermal granulation tissues with abundant records of fibroblastic activity and mixed inflammatory cell infiltrates and showed 17.2%, 25.8%, and 22.2% records of dermal mature collagen fibers, respectively. In conclusion, phage vB_Pae_SMP1 or vB_Pae_SMP5, or the two-phage cocktails formulated as hydrogels, were able to manage the infection of CRPA in burn wounds, and promoted healing at the injury site, as evidenced by the histopathological examination, as well as a decrease in animal mortality rate. Therefore, these phage formulae can be considered promising for clinical investigation in humans for the management of CRPA-associated skin infections.
Characterization of HIV-1 Transmission Clusters Inferred from the Brazilian Nationwide Genotyping Service Database
Authors: Andrade Paula , Arantes Ighor , Tanuri Amilcar , Bello Gonzalo , Gräf Tiago
Published: December 2022

The study of HIV-1 transmission networks inferred from viral genetic data can be used to clarify important factors about the dynamics of HIV-1 transmission, such as network growth rate and demographic composition. In Brazil, HIV transmission has been stable since the early 2000s and the study of transmission clusters can provide valuable data to understand the drivers of virus spread. In this work, we analyzed a nation-wide database of approximately 53,000 HIV-1 nucleotide pol sequences sampled from genotyped patients from 2008–2017. Phylogenetic trees were reconstructed for the HIV-1 subtypes B, C and F1 in Brazil and transmission clusters were inferred by applying genetic distances thresholds of 1.5%, 3.0% and 4.5%, as well as high (>0.9) cluster statistical support. An odds ratio test revealed that young men (15–24 years) and individuals with more years of education presented higher odds to cluster. The assortativity coefficient revealed that individuals with similar demographic features tended to cluster together, with emphasis on features, such as place of residence and age. We also observed that assortativity weakens as the genetic distance threshold increases. Our results indicate that the phylogenetic clusters identified here are likely representative of the contact networks that shape HIV transmission, and this is a valuable tool even in sites with low sampling density, such as Brazil.
Estrus Detection in a Dairy Herd Using an Electronic Nose by Direct Sampling on the Perineal Region
Authors: Ali Asmaa S. , Jacinto Joana G. P. , Mϋnchemyer Wolf , Walte Andreas , Gentile Arcangelo , Formigoni Andrea , Mammi Ludovica M. E. , Csaba Bajcsy Árpád , Abdu Mohamed S. , Kamel Mervat M. , Ghallab Abdel Raouf Morsy
Published: December 2022

Estrus detection is very important for the profitability of dairy herds. Different automatic systems for estrus detection have been developed over the last decades. Our study aimed to assess the ability of the electronic nose (EN) MENT-EGAS prototype to detect estrus, based on odor release from the perineal headspace in dairy cattle by direct sampling. The study was performed in an Italian dairy farm using 35 multiparous Holstein–Friesian cows. The cows were divided into three groups: group I included 10 lactating 5-month pregnant cows, group II included 19 lactating cycling cows, and group III included 6 cows that were artificially inseminated 18 days before the trial. Odors from the perineal headspace were collected using the MENT-EGAS prototype. In group I, odors were collected once a day for 5 consecutive days. In group II, odors were collected twice daily from day 18 until day 1 of the reproductive cycle. In group III, odors were also collected twice daily from the presumable day 18 of gestation until day 22. Principal component analyses (PCA) of the perineal headspace samples were performed. PCA in group I revealed no significant discrimination. PCA in group II revealed clear discrimination between proestrus and estrus, and between estrus and metestrus but no significant discrimination was obtained between proestrus and metestrus. PCA in group III revealed that in four cows the results were similar to group I and in two cows the results were similar to group II. On day 40 of the presumable pregnancy, the ultrasound examination revealed that only the four cows were pregnant and the other two cows were regularly cycling. On the basis of our findings, we conclude that it is possible to accurately detect estrus in dairy cattle from directly collected odor samples using the MENT-EGAS prototype. This represents the first study of estrus detection using an EN detection by direct sampling. EN technologies, such as MENT-EGAS, could be applied in the future in dairy cattle farms as a precise, non-invasive method for estrus detection.
PERSPEKTIF NILAI PERUSAHAAN DITINJAU DARI ASPEK SET KESEMPATAN INVESTASI (MBVE) DAN PENGELUARAN MODAL (CAPEX)
Authors: Nopianti Tanti , Suhayati Ely
Published: December 2022

Tujuan dari penelitian ini adalah untuk mengetahui Investment Opportunity Set (MBVE) dan Capital Expenditure (CAPEX) berpengaruh terhadap Nilai Perusahaan (PBV) Perusahaan Subsektor Telekomunikasi yang terdaftar di BEI 2016-2020. Metode dalam penelitian ini menggunakan deskriptif dan verifikatif. Pengambilan sampel menggunakan pooled data dengan time series dan cross section pada 6 perusahaan di Subsektor Telekomunikasi tahun 2016-2020 sehingga terdapat 30 data. Alat analisis yang digunakan adalah analisis regresi linier berganda dan pengujian hipotesis menggunakan Software SPSS Statistics 20 for Windows. Hasil uji hipotesis menyatakan bahwa secara parsial Investment Opportunity Set berpengaruh sangat besar terhadap nilai perusahaan dan belanja modal berpengaruh tidak signifikan terhadap nilai perusahaan. Artinya secara simultan Investment Opportunity Set dan Capital Expenditure berpengaruh signifikan terhadap Nilai Perusahaan. Dimana jika Set Peluang Investasi dan Pengeluaran meningkat maka Nilai Perusahaan juga akan meningkat dari waktu ke waktu.
THE EFFECT OF COMPANY SIZE AND TAXES ON TRANSFER PRICING
Authors: Suhartono Suhartono , Herdianova Desi Dona , Yanti Vera Agustina , Hakim Lukman , Kuspriyono Taat
Published: December 2022

Transfer pricing has become a global problem that can also occur in Indonesia. Multinational companies with many entities in various countries with different tax rate policies can encourage transfer pricing. The influence of the central company which is very dominant in the management policies of its entity companies through special relationships is the key to transfer pricing, especially in manufacturing companies. This study aims to analyze the impact of company size and tax on transfer pricing in 12 (twelve) registered automotive and component manufacturing sub-sector companies in 2018-2020. The analysis technique tested the hypothesis with logistic regression, interaction test and logistic regression significance test to determine the probability. The results show that company size and taxes have a negative impact on transfer pricing.

 

Keywords: company size, tax, transfer pricing
Vivencias masculinas após confirmação do diagnóstico de HIV
Authors: Das Silva Emanuela Alves , Castro Raianne Silva , Mota Francisco Gabriel de Andrade , Mota João Victor Farias , Paz Samuel de Vasconcelos , Tavares Ramon Gonçalves , Queiroz Danielle Teixeira , Farias Geysa Maria Nogueira , Gonçalves Valeria Freire , Guanabara Marilene Alves Oliveira
Published: December 2022

Objetivo: Conhecer a vivência de homens após o diagnóstico de HIV. Método: Trata-se de uma pesquisa do tipo descritiva com abordagem qualitativa. A coleta de dados foi realizada nos meses de fevereiro e março de 2021, no ambulatório de infectologia de uma unidade de atenção secundária através de entrevistas com homens que receberam diagnostico de HIV. Para compor a análise dos depoimentos utilizou-se de categorização. Resultados: A partir da compreensão dos depoimentos no momento do diagnóstico, alguns sentimentos foram desvelados tais como medo, angustia e rejeição, além disso, ficou evidenciado a invisibilidade familiar na participação do diagnóstico pela dificuldade de comunicação, em virtude do medo da discriminação e o estigma sofrido. Outra vivência relatada foi as relações fragilizadas com suas parcerias pela dificuldade em expor seu status sorológico e comprometer seus relacionamentos afetivos. Conclusão: Ao final dessa pesquisa, foi possível perceber que o indivíduo com HIV ainda é estigmatizado, na maioria dos depoimentos ficou evidente que os sentimentos de medo, tristeza e angústia estavam presentes desde o diagnóstico até os dias atuais, e que, a família, amigos e parceiros foram aqueles de quem menos tiveram apoio por manter em segredo sua condição sorológica com receio de rejeição.
Aplicação das práticas integrativas e complementares na odontologia: revisão integrativa
Authors: Budach Frida Ariadni , Dos Santos Giselma Leite , Da Silva Gisselly Maria Campos , Silva Isabela Regina Grilo , Pimentel Bárbara Vieira , Goya Suzana , Fujimaki Mitsue , Lolli Luiz Fernando
Published: December 2022

As práticas integrativas e complementares são tratamentos que estimulam os mecanismos naturais de prevenção e recuperação da saúde, com relatos de utilização também na odontologia, como recurso terapêutico de apoio. Objetivou-se realizar uma revisão integrativa para avaliar o emprego e uso das práticas integrativas e complementares na odontologia e verificar o amparo legal do cirurgião dentista para sua aplicação. A coleta dos dados foi realizada nos meses de maio e junho de 2022 nas bases de dados ‘biblioteca virtual de saúde’ e google scholar. Para o levantamento dos trabalhos, na base biblioteca virtual de saúde foi utilizada a estratégia de busca a partir de descritores: dentistry e complementary and alternative medicine fazendo o cruzamento utilizando o operador boleano and e selecionando artigos publicados a partir de 2010. Já na base google scholar foi utilizado para pesquisa o termo ‘terapias complementares em odontologia’ selecionando artigos a partir de 2010 excluindo patentes e citações. Foram incluídos 21 artigos e 9 documentos oficiais. Verificou-se que as práticas integrativas e complementares têm várias aplicações na odontologia, especialmente no condicionamento do cliente. Torna-se necessário ampliar o acesso ao conhecimento dos odontólogos a essas terapias alternativas, sendo sugerida a inclusão desta temática na graduação.
A (im)possibilidade de responsabilização civil dos influenciadores digitais por publicidade de produtos e serviços de consumo veiculadas nas redes sociais
Authors: Castelo Tiffani Rauta , André Victor Conte
Published: December 2022

Diante do avanço da tecnologia e tamanha utilização das redes sociais, vive-se em uma sociedade de hiperconsumo, onde os influenciadores digitais, compartilham suas opiniões e estilo de vida, sendo capaz de mudar o comportamento dos seus seguidores. O artigo avalia a responsabilidade civil dos influenciadores digitais em razão de indicação de produtos e serviços nas redes sociais, começando da compreensão de quem são essas personalidades e como operam nas mídias sociais, se existe relação de consumo entre eles e seus seguidores, quais órgãos jurídicos regulam essa relação, para que, ao final, pudesse analisar juridicamente a possibilidade dos influenciadores se responsabilizarem civilmente pelos produtos e serviços divulgados nos chamados publiposts. Conclui-se pela responsabilidade objetiva e solidária dos influenciadores, uma vez que possuem vantagem em relação aos consumidores e agem precisamente por meio de indicação de produtos e serviços, impactando diretamente nas escolhas de consumo dos seus seguidores.
Efetividade de classificação de lesões potencialmente malignas – revisão da literatura
Authors: Brito Amon Felipe Souza , Pinheiro Janaina Maciel , Silva Geovanna Gonçalves , Cruz Daniele Amorim da , Estrela Cyntia Rodrigues de Araújo
Published: December 2022

Objetivo: O objetivo desta revisão da literatura foi comparar as evidências da capacidade do sistema de graduação histológica binária em relação aos sistemas da OMS (Organização Mundial de Saúde), ambos para a identificação de displasias orais potencialmente malignas, permitindo revelar o método mais eficaz para realizar diagnósticos, auxiliando o cirurgião-dentista no diagnóstico de lesões potencialmente malignas favorecendo os parâmetros de avaliação do diversificado grupo de neoplasias potencialmente malignas. Desenvolvimento: foi realizada uma pesquisa de artigos sobre displasias malignas e potencialmente malignas trabalhando o método de diagnóstico dos sistemas binário e OMS por meio de buscas nas bases de dados PubMed, e SciELO, possibilitando a meta analise. Considerações finais: Observou-se que ambos os sistemas são semelhantes na capacidade de previsão da transformação maligna, entretanto, o sistema binário mostrou melhor concordância do que o sistema OMS ao classificar lesões potencialmente malignas.
Atendimentos de urgência por transtorno de humor em idosos antes e durante a pandemia de Covid-19 em Goiás
Authors: Oliveira Sandy Freitas , Gomes Gustavo Vitoria , Assunção Gilcilene Vieira , Quinan Paulo Victor Monteiro , Machado Debora Oliveira Queiroz , Cordeiro Elisa Raquel Vieira Gratão , Junior Carlito José Lucas
Published: December 2022

A COVID-19 (coronavirus disease 2019) é uma doença gerada pelo vírus da família dos coronavírus denominado SARS-COV-2. Sua via de entrada predileta são as vias respiratórias e, do mesmo modo, o sítio de infecção mais marcante é o sistema respiratório, gerando, na maioria dos casos, a sintomatologia clássica de uma infecção viral das vias aéreas. No entanto, a doença tem o potencial de se espalhar por todos os sistemas, bem como de gerar resposta multissistêmica, em razão da desregulação imune que pode provocar. A doença, entretanto, não se resume apenas ao quadro agudo, complicado ou não. Com o desenvolvimento da pandemia, que já se aproxima do seu segundo ano, foi possível perceber que alguns pacientes apresentam sintomatologia crônica, logo após ou algum tempo depois da negativação dos testes sorológicos, inclusive psiquiátricos, cujo aparecimento implica em piora da qualidade de vida. A população como um todo foi afetada pelo vírus e pelas modificações do cotidiano que as medidas restritivas - numa tentativa de controlar o contágio em massa, que os órgãos de saúde em todo o mundo optaram por implantar, mas certos grupos populacionais foram atingidos de forma mais dramática, tanto pelo vírus quanto por essas medidas. Os idosos são um desses grupos mais afetados pela pandemia no que tange à saúde mental, repercutindo na mortalidade de forma geral, e também na morbidade, com o desenvolvimento de sintomas novos ou descompensação de doenças previamente controladas. Tendo isso em vista, o presente trabalho pretende avaliar se há significância no número de internações por transtornos de humor no Estado de Goiás antes e durante a pandemia do novo-Coronavírus.
Produção de ácido hialurônico por streptococcus zooepidemicus em sacarose com suplementação de aminoácidos
Authors: Pereira Hanny Cristina Braga , Pan Nicole Caldas , Vignoli Josiane Alessandra , Celligoi Maria Antonia Pedrine Colabone
Published: December 2022

O ácido hialurônico (AH), é um polissacarídeo que possui numerosas aplicações naturais devido às suas propriedades bioquímicas e, portanto, há grande interesse por parte das indústrias cosmética, médica e farmacêutica na sua obtenção. O AH pode ser extraído de tecidos animais ou obtido pelo cultivo de bactérias, sendo a última via mais vantajosa. Assim, a otimização do meio de cultivo para a produção do polímero procariótico é de grande importância. Este trabalho teve por objetivo avaliar o efeito da concentração de sacarose e extrato de levedura, bem como de arginina e glutamina na produção de ácido hialurônico por Streptococcus equi subsp. zooepidemicus. Foram realizadas fermentações de acordo com um planejamento fatorial completo 3² (com dois pontos centrais), utilizando concentrações de 20, 30 e 40 g.L-1 de sacarose e extrato de levedura. Encontrada a relação C:N ótima para produção de AH, testou-se o efeito da concentração de arginina e glutamina (0,0 a 3,0 g.L-1) através de planejamento fatorial completo 3² (com dois pontos centrais). Apenas o extrato de levedura mostrou efeito significativo, exibindo influência positiva na produção de AH. No entanto, observou-se um aumento na produção de AH com a adição dos aminoácidos. A maior produção do polímero (1,096 g.L-1) ocorreu em 30 g.L-1 de sacarose, 40 g.L-1 de extrato de levedura, 1,5 g.L-1 de arginina e sem adição de glutamina.
Analisis QoS Tunneling pada Virtual Conference
Authors: Liando Jonathan , Widiasari Indrastanti Ratna
Published: December 2022

Komunikasi menjadi bagian dari teknologi informasi yang mengalami banyak perubahan dan penyesuaian terutama semenjak pandemi COVID-19. Media komunikasi yang sering digunakan pun pada situasi ini seperti Zoom dan Google Meets juga mengalami hal serupa. Salah satu hal yang sering terjadi ketika menggunakan layanan Virtual Conference adalah adanya ketidakstabilan jaringan. Penelitian ini mencoba menggunakan Tunneling sebagai penyelesaian terhadap masalah ketidakstabilan jaringan karena Tunneling menggunakan jalur yang terisolasi. untuk memastikan stabilnya jaringan dalam sebuah aplikasi Virtual Conference diperlukan analisis untuk melihat performa jaringan yang dipakai. Penelitian ini menggunakan QoS sebagai metode untuk mengukur kestabilan performa dari suatu jaringan dengan melihat empat indikator, Throughput, Packet loss, Delay, jitter. Dari hasil perhitungan yang dilakukan menggunakan tiga jenis Tunneling Protocol yaitu GRE, IPSEC, dan PPTP sebagai perbandingan. Kesimpulan yang didapatkan adalah PPTP menjadi Tunneling Protokol yang bagus untuk diterapkannya Tunneling pada aplikasi Virtual Conference
Pengenalan Aplikasi Analisis Data untuk Pengelompokkan Pemasaran Jamur Tiram
Authors: Eka Praja Wiyata Mandala  , Dewi Eka Putri  , Randy Permana
Published: December 2022

Jamur tiram merupakan jenis jamur yang dapat dikonsumsi baik jamur segar maupun jamur yang sudah diolah menjadi berbagai makanan. Budidaya jamur tiram menjadi salah satu usaha yang dilakukan oleh para petani jamur karena proses budidaya yang mudah dilakukan, media tanam jamur tiram yang mudah didapatkan hingga pengolahan jamur tiram yang dapat dijadikan berbagai macam makanan. Salah satu kelompok budidaya jamur tiram berada di Kampung Jamur, kecamatan Pauh Kota Padang. Di Kampung Jamur, para petani jamur melakukan budidaya jamur tiram mulai membuat media tanam, menghasilkan jamur tiram segar hingga produk makanan olahan dari jamur tiram. Beberapa produk yang dihasilkan adalah jamur segar, rendang jamur, es krim jamur, agar-agar jamur dan kerupuk jamur. Pemasaran produk ini dilakukan melalui forum jual beli di media sosial, menitipkan produk di minimarket sekitar dan pembelian secara langsung ke Kampung Jamur. Permasalahan yang diperoleh adalah kecilnya area pemasaran dan sedikitnya media pemasaran yang digunakan untuk memasarkan produk tersebut. Kegiatan ini memberikan pengetahuan kepada para petani jamur untuk mengembangkan area dan media pemasaran menggunakan marketplace. Tujuan dari kegiatan ini adalah mengenalkan sebuah aplikasi untuk melakukan analisis data yang dapat digunakan untuk melakukan klasterisasi pemasaran produk olahan jamur tiram. Aplikasi yang dikenalkan adalah aplikasi Weka versi 3.8.3. Hasil dari kegiatan ini adalah tingginya keingintahuan petani jamur tentang cara pemasaran produk dengan media promosi lainnya dan adanya minat dari beberapa petani jamur untuk menggunakan aplikasi Weka 3.8.3 dalam mengelompokkan pemasaran produk olahan jamur tiram.
Evaluation the Effect of 50 g Glucose Tolerance Test on Oxidative Stress and Interleukin-8 Parameters in Prediabetic Pregnancy
Authors: ÖZMEN Zeliha Cansel , MERTOĞLU Cuma , AYDOĞAN Leyla , NACAR Mehmet Can , DEVECİ Köksal , KATAR Muzaffer , ÖZSOY Zeki
Published: December 2022

Background: The aim of this study is to evaluate the effect of 50 g oral glucose tolerance test (OGTT) on oxidative stress and interleukin-8 (IL-8) parameters in prediabetic pregnant women.
Materials and Methods: Fasting and 1 hour blood samples were collected from 79 pregnant women who were administered 50 gr OGTT. Patients with a 1 hour blood glucose level of 140–200 mg/dl were considered as the prediabetic group. Thereafter, routine biochemical parameters and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and interleukin-8 (IL-8) parameters were measured from the serum samples taken during fasting and at 1 hour.
Results: The serum GPx and SOD levels of the prediabetic group were remarkably lower than that of the control group (p<0.05). Whereas the serum IL-8 levels of the prediabetic group were significantly higher than that of the control group (p<0.05). When the fasting and 1 hour levels of the parameters were compared during OGTT, SOD levels were significantly decreased (p<0.001) and IL-8 levels were significantly higher (p<0.001).
Conclusions: In conclusion, it was found that serum GPX and SOD levels decreased, while serum IL-8 levels increased in prediabetic pregnant women; however, when 50 g OGTT was administered to these patients, SOD levels decreased and IL-8 levels increased. These results we obtained suggest that oxidative stress and systemic inflammation that are already present in prediabetic pregnant women may be triggered by 50 g OGTT, posing negative risk factors for pregnant women.
Ortaokul Öğretmenlerinin Okul Dışı Öğrenmeyi Düzenlemeye İlişkin Algılarının Çeşitli Değişkenler Açısından İncelenmesi
Authors: BOZPOLAT Ebru , ALEM Fatma
Published: December 2022

Bu araştırmanın amacı, ortaokul öğretmenlerinin okul dışı öğrenmeyi düzenlemeye ilişkin algılarını çeşitli değişkenler açısından incelemektir. Nicel araştırma yöntemi kullanılan araştırmada, tarama modeli tercih edilmiştir. Araştırmanın örneklemini 2020-2021 eğitim-öğretim yılı bahar döneminde Sivas ili Merkez ilçesinde Millî Eğitim Bakanlığına bağlı ortaokulda görev yapan 352 öğretmen oluşturmaktadır. Araştırma verilerinin toplanmasında Bolat ve Köroğlu (2020) tarafından geliştirilen “Okul Dışı Öğrenmeyi Düzenleme Ölçeği (ODÖDÖ)” kullanılmıştır. Verilerin analizinde; betimsel istatistik, bağımsız gruplar t testi, tek yönlü varyans analizi (ANOVA), Scheffe testinden yararlanılmıştır. Araştırma sonucunda; ODÖDÖ’nün maddelerine ilişkin bilgi, planlama, değerlendirme alt boyutlarında ve ölçeğin tümünde ortaokul öğretmenlerinin “orta düzeyde katılıyorum” düzeyinde; uygulama alt boyutunda ise “çok katılıyorum” düzeyinde algıya sahip oldukları tespit edilmiştir. Araştırmada, ortaokul öğretmenlerinin okul dışı öğrenmeyi düzenlemeye ilişkin algılarının eğitim düzeyi, okul dışı öğrenmeyi düzenleme ile ilgili eğitim alma durumu, okul dışı öğrenmeyi düzenleme ile ilgili etkinlik düzenleme durumu ve sınıf mevcudu değişkenleri açısından anlamlı bir farklılık olduğu tespit edilmiştir.
HISTOPATHOLOGY IMAGE CLASSIFICATION USING HYBRID PARALLEL STRUCTURED DEEP-CNN MODELS
Authors: DSOUZA Kevin Joy , ANSARI Zahid Ahmed
Published: December 2022

The healthcare industry is one of the many out there that could majorly benefit from advancement in the technology it utilizes. Artificial intelligence (AI) technologies are especially integral and specifically deep learning (DL); a highly useful data-driven technology. It is applied in a variety of different methods but it mainly depends on the structure of the available data. However, with varying applications, this technology produces data in different contexts with particular connotations. Reports which are the images of scans play a great role in identifying the existence of the disease in a patient. Further, the automation in processing these images using technology like CNN-based models makes it highly efficient in reducing human errors otherwise resulting in large data. Hence this study presents a hybrid deep learning architecture to classify the histopathology images to identify the presence of cancer in a patient. Further, the proposed models are parallelized using the TensorFlow-GPU framework to accelerate the training of these deep CNN (Convolution Neural Networks) architectures. This study uses the transfer learning technique during training and early stopping criteria are used to avoid overfitting during the training phase. these models use LSTM parallel layer imposed in the model to experiment with four considered architectures such as MobileNet, VGG16, and ResNet with 101 and 152 layers. The experimental results produced by these hybrid models show that the capability of Hybrid ResNet101 and Hybrid ResNet152 architectures are highly suitable with an accuracy of 90% and 92%. Finally, this study concludes that the proposed Hybrid ResNet-152 architecture is highly efficient in classifying the histopathology images. The proposed study has conducted a well-focused and detailed experimental study which will further help researchers to understand the deep CNN architectures to be applied in application development.
Tratamiento con glucocorticoides en pacientes con inflamación relacionada a angiopatía amiloide cerebral: ¿qué tan útil son?
Authors: Picón-Jaimes Yelson A. , Mendoza-Gallego Valentina , Jaramillo-Valenzuela Ernesto , Monroy-Martínez Angie L. , Ortega-Ovalle Andrés D. , Navarro-Bautista Freddy E. , Contreras-Castillo Andrea P. , Marín-Calderón Hernando J.
Published: December 2022

Objetivo. El objetivo de esta revisión consiste en analizar la evidencia más reciente sobre la utilidad de los glucocorticoides en pacientes con Inflamación relacionada a Angiopatía Amiloide Cerebral (IrAAC). Métodos. Revisión sistemática. Se llevó a cabo una búsqueda bibliográfica en los motores de búsqueda y bases de datos bases de datos PubMed, ScienceDirect, Embase, EBSCO y MEDLINE, incluyendo cualquier artículo relacionado con la evaluación de la utilidad, eficacia o seguridad de los glucocorticoides sobre la inflamación de angiopatía amiloide cerebral, sería incluido, dando prioridad a los estudios originales y a las revisiones sistemáticas y meta-análisis. Resultados. Se encontró que, la evidencia actual sobre su uso es limitada, derivando principalmente de casos reporte, series de casos y estudios retrospectivos. No obstante, parece ser que estos agentes ocasionan una respuesta favorable con solución parcial de las manifestaciones neurológicas de manera inmediata y/o progresiva a mediano y largo plazo, así como de los cambios anormales imagenológicos, dados por edema vasogénico y microsangrados corticales y subcorticales, aunque la mejoría de este último, no es muy marcado. Conclusión. La evidencia actual sobre el uso de glucocorticoides y su impacto sobre desenlaces clínicos y neuroimagenológicos es limitada.
Characteristics of fishery in open sea and conventional areas of the World ocean in 2020 according to satellite monitoring data and prospects for the development of the Russian fishery in these areas
Authors: Dubishchuk M. M.
Published: December 2022

One of the strategic goals of the Russian fishing industry in modern conditions is to expand the activities of the fishing fleet to the open ocean areas. Based on modern data from satellite monitoring of fishing vessels in the World Ocean for 2020, the paper provides a characteristic of the state of oceanic fisheries. The most active fishing zones in the open part of the World Ocean outside the exclusive economic zones of coastal states, which may be of interest for the development of domestic oceanic fishing, have been identified and described. The most active fishing takes place in the open areas of the World Ocean, which are not covered by the regulation of regional fisheries organizations, and especially active is the fishing for species that are not regulated by them. First of all, squid are such commercial species. Tunas and other pelagic predators are also promising species in open areas of the World Ocean. The main types of fishing vessels in the open ocean are longline fishing vessels, jigging vessels and purse seiners. The information provided will be in demand when organizing the fishing of biological resources in areas beyond national jurisdiction, as well as preparing exploratory research expeditions to promising fishing areas.
RIS Channel Decoupling Based on Decomposition of Receiving and Transmission Matrix Components of RIS Regulation Matrix
Authors: Zhao Yajun , Lv Xin
Published: December 2022

In this letter, a novel reconfigurable intelligent surface (RIS) channel decoupling based on a decomposition of receiving and transmitting matrix components of RIS regulation matrix is proposed to simplify the calculation of RIS beamforming matrix. The idea is to decompose an RIS regulation matrix into a receiving matrix and a transmitting matrix. Thus, the decoupling of RIS cascaded channels is realized for the calculation of the regulation matrix. Furthermore, the single UE and multi-UE scenarios are discussed respectively, and the corresponding solutions are given. The proposed schemes are simulated and validated. The numerical simulation results indicate that the simplified algorithm based on channel decoupling can achieve the expected performance.
Regional language toxic comment classification
Authors: Parikh Yashkumar , Fiaidhi Jinan
Published: December 2022

Social media sites are gaining popularity day by day. They are best for communication, business, entertainment, and many other things. After more than a decade, social media have become very influential. On the flip side, fake news, hate speech, and online trolls are the biggest concerns because of social media. So, a solution to curb this issue is needed, especially in regional languages. Many social media platforms support regional languages. This paper will provide a machine learning-based solution to this problem. The focus of this paper is to classify comments written in regional languages. Firstly, a dataset has been created in Gujarati, Hindi, English, Marathi, and Punjabi languages. After that, different machine learning and deep learning models are applied to the multilingual dataset. At last, a comparison of all model performances was made. 
Adapted Adversity Quotient Program–Oxymoron or Opportunity? A Study of Special Education Teachers in Raipur, Chhattisgarh
Authors: Sharma Avichal , Pandey Pallavi , Padmawati Dr. K
Published: December 2022

It is commonly believed that some types of schools, such as those catering to special children, are difficult or problematic places to work (Pratt cited in Nguyen, 2002). Freeman (1988) made the observation that in order to properly care for children who have particular requirements, teachers need to fulfil not only the duty of an educator but also that of a nurse and a parent. Because of this, teachers of special education are more likely to experience burnout and stress (Freeman, 1988). It is necessary to improve special education teachers' capacity to persevere in the face of adversity because they are always facing new obstacles in their work. Therefore, it is essential to have an understanding of one's adversity quotient (AQ). The capacity to persevere in the face of adversity is a crucial component in determining one's quality of life. The findings showed that individuals with a high AQ fared better than those with a low AQ (Stoltz, 1997). In order to raise the adversity quotient (AQ) of the special education teachers working at a special education school in Raipur (Chhattisgarh), three industry professionals designed and tested an Adversity Quotient (AQ) Program. The post- test scores dramatically improved to a level that was considered to be reasonably high after the AQ Program that had been established was put into action. For the purpose of determining their AQ, the Adversity Response Profile Quick Take (Stoltz, 1997) was utilized. In the United States, the Maricopa School District in Arizona implemented a programme called AQ to encourage educators "to achieve more with less." The findings of this study suggest that the adversity quotient could be incorporated into faculty development programmes in order to help special education teachers become more resilient and capable members of the labor force.
Relationship between Metabolic Syndrome on Grade and Stage of Urothelial Carcinoma of Bladder
Authors: Kundu Biswanath , Ahmed Furkan , Uddin Mohammad Haris , Uddin Muhammad Zia , Bari AKM Akramul , Islam Dr. Md. Rafiqul
Published: December 2022

Introduction: Bladder cancer is the ninth most common cancer in the world, with 430,000 new cases diagnosed in 2012. Carcinoma bladder occurs with an overall incidence of 2.25% (10,000 annually), 3.67% among males and 0.83% for females. Metabolic syndrome (MS) is characterized by overweight, hypertension, elevated blood glucose, and dyslipidaemia. Cigarette smoking and occupational exposure are the main risk factors for upper tract urothelial carcinoma and urinary bladder cancer. Objective: To elucidate the relationship between metabolic syndrome on grade and stage of urothelial carcinoma of bladder. Methods: We retrospectively analyzed study was carried out at Dept. of Urology, Sir Salimullah Medical College Hospital, Dhaka, Bangladesh from January to December 2021. One hundred (100) patients who were first time detected cases of carcinoma bladder and were operated. Consent was required for surgical procedure as mandatory for the procedure. Patient related factors (Age, height and weight), histopathological analysis (stage and grade,) and comorbid conditions (the presence of hypertension, diabetes mellitus, and triglyceride level and body mass index) were evaluated. Non-invasive papillary urothelial neoplasms of low malignant potential (PUNLMP), Ta and T1 tumors were classified as lower stage and T2, T3, and T4 tumors as higher stage bladder cancers. Stasticial Analyses was done using chi-square tests and logistic regression analysis. Results: Total 100 patients 82 (82%) were males and 18(18%) were females with mean age of 65.5±4.8 years. MS was found in 32 (32%) patients. Hypertriglyceridemia, Hypertension, Diabetes mellitus (DM) and BMI ≥25 kg/m2 were present in 25%, 32%, 25%, and 40% of patients respectively. The pathological characteristic between patients with or without MS is demonstrated. Metabolic syndrome was significantly associated with histologic grade (p<0.05) and stage (p=0.04) of bladder cancer. Components such as diabetes (p=0.005, OR=1.92) and ....
Ear, Nose & Throat Problems among Pregnant Women of Bangladesh-A Study of 140 cases
Authors: Uddin Dr. Md. Salah , Begum Dr. Farjana , Parvin Dr. Tahmina , Noor Dr. Tania , Easmin Dr.Sabina , Haque Dr. Md. Aminul , Haque Dr. Fahmida , Islam Dr. Md Rafiqul
Published: December 2022

Introduction: Pregnancy is a special period of altered physiological & psychological condition of woman which is mainly due to the secretion of hormones from placenta like estrogen, progesterone, HCG (Human Chorionic Gonadotrophin), Human Placental Lactogen, Somatomammotropin, Human Chorionic Thyrotrophin & Human Chorionic Corticotrophin etc. In this changed internal milieu a special set of diseases (problems) occur in pregnant women. This study aimed to find out the ear, nose & throat problems among pregnant women of Bangladesh. Methods: A Cross- sectional study to find out the common ENT problems that face our pregnant ladies of various age and different part of pregnancy which was observed both at the tertiary level hospitals in Dhaka city & rural consultation center at Chandpur district. Results: This study included 140 pregnant ladies of 16 to 45 years of ages of whom mostly 61(43.57%) presented with ear (otological) problems followed by nasal (rhinological) problem 40(28.57%) then throat 29(20.71%) & neck disorders 10(7.14%). Among all these diseases otomycosis scores the highest comprising 29(20.7%), followed by lumpy feeling in throat 26(18.5%) followed by nasal blockage including deviated nasal septum, allergic rhinitis, sinusitis, hypertrophied turbinates 25(17.8%) , CSOM 16( 11.4%) & altered smell sensation10(7.1%). Of them mostly 94(67.14%) in the age group of 21-30 years, followed by 31-40 years of age group 25(17.85%), then age group up to 20 years actually (16-20years) which comprises 19(13.57%) and least patients in the age group of above 41 years this group comprises only 2(1.42%) patients. Most of the presenting patients were multiparous 86 (61.4%) & 54 (28.6%) were primi. Among all presenting women mostly presented in 1st (40.7%) & 2nd (40%) trimester and the rest in 3rd trimester. Conclusion: Pregnancy is a special physiological condition where a unique group of ENT problems occurred during this period. Although some of them are self-reverting ..
Foundation phase teachers' experiences of physical education in low-resourced schools: Implications for continuing professional development
Authors: KAHTS-KRAMER Samantha , Du Randt Rosa , Wood Lesley
Published: December 2022

Physical Education (PE) provides Foundation Phase learners aged six to nine the opportunity to develop their cognitive, social, emotional and physical domains. However, if these benefits are not realised for learners in low-resource schools, contextually-based and needs-driven continuing professional teacher development (CPTD) courses may be warranted. The aim of this study was to interpret Foundation Phase teachers’ experiences of teaching PE in low-resource schools, to inform the design of CPTD in this area. A qualitative research design situated within the interpretive paradigm was employed. Twenty-four (24) Foundation Phase teachers working in nine Quintile Three schools in Gqeberha participated in semi-structured interviews. The data was thematically analysed. Three broad themes were identified, namely personal barriers, systemic barriers and positive responses to existing challenges. There was a significant overlap between the themes, which highlights the complexity of teachers’ experiences and perceptions of PE. The findings support a transformative and collaborative approach to CPTD to assist Foundation Phase teachers with teaching PE in the context of disadvantaged low-resource schools.
Penanaman Nilai Kesederhanaan Sejak Dini dalam Perspektif Hadits
Authors: Amini Nur , Sari Yosi Melda
Published: December 2022

Penanaman nilai kesederhanaan diwujudkan dengan penguatan Pendidikan karakter sejak dini, penerapan pola hidup berlebihan dan bermewah-mewahan bagi anak usia dini, sehingga berdampak buruk terhadap pembentukan karakter anak yang jauh dari prilaku sederhana. Tujuan dari penelitian ini adalah untuk mengetahui manfaat serta proses pembelajaran penanaman nilai kesederhanaan sejak dini dalam persepktif hadis. Jenis penelitian yang digunakan adalah penelitian kualitatif melalui pendekatan deskriptif. Dalam penelitian kualitatif yang menjadi subjek yaitu kepala sekolah, dua orang guru, dan anak-anak dari TK Islam Terpadu An-Najah. Hasil penelitian ini menujukkan bahwa proses penanaman nilai kesederhanaan dilakukan dengan membacakan hadits secara bersama-sama, menyanyikan hadits yang berkenaan dengan nilai kesederhanaan dan juga menjelaskan hadits mengenai pola hidup sederhana dengan menceritakan maksud dari hadits yang dimaksud agar anak mudah memahami dan merasa tertarik atas materi yang diajarkan. Kegiatan tersebut memberikan banyak manfaat. Diantaranya anak-anak dibiasakan untuk melakukan pola hidup yang sederhana dan tidak berlebihan. Merasa cukup atas apapun yang dimiliki saat ini. Serta memanfaatkan secara kreatif barang-barang yang dimiliki, dan selalu merasa bersyukur.
No Meaningful Difference in Attentional Bias Between Daily and Non-Daily Smokers
Authors: Bartlett James , Jenks Rebecca , Wilson Nigel
Published: December 2022

Both daily and non-daily smokers find it difficult to quit smoking long-term. One factor associated with addictive behavior is attentional bias, but previous research in daily and non-daily smokers found inconsistent results and did not report the reliability of their cognitive tasks. Using an online sample, we compared daily (n = 106) and non-daily (n = 60) smokers in their attentional bias towards smoking pictures. Participants completed a visual probe task with two picture presentation times: 200ms and 500ms. In confirmatory analyses, there were no significant effects of interest, and in exploratory analyses, equivalence testing showed the effects were statistically equivalent to zero. The reliability of the visual probe task was poor, meaning it should not be used for repeated testing or investigating individual differences. The results can be interpreted in line with contemporary theories of attentional bias where there are unlikely to be stable trait-like differences between smoking groups. Future research in attentional bias should focus on state-level differences using more reliable measures than the visual probe task.