bluuebunny/crossref_metadata_2025 huggingface dataset:
WITHDRAWN: Chemical Constituents from the Root Bark of Jatropha curcas and their Cytotoxic Activities
Authors: Mei Lang Hua , Long Jian , Wu Shu E. , Mei Mei E. , Mei Di , Tong Ling , Zhang Qi Min , Xiao Jia Biao , Zheng Shao Lang , Huang Hai
Published: August 2022

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Patterns of Interstitial Lung Disease in Egyptian Patients with Systemic
Sclerosis: Relation to Disease Parameters
Authors: Abdelati Abeer Ali , Deghady Akram Abd-Elmonaem , Abdelhady Ahmed Mohamed , Bastawy Rim Aly , Shaaban Ahmed
Published: August 2022

Background:

Pulmonary involvement is the most common leading cause of morbidity and mortality associated with systemic sclerosis. Therefore, identifying the various patterns of pul-monary affection is crucial in the clinical management of these patients. In the current study, we aim to investigate the patterns of interstitial lung disease (ILD) associated with SSc patients (SSc-ILD) and their relation to serologic markers and clinical parameters.

Methods:

A cross-sectional study was undertaken on thirty-four adult SSc patients who met the 2013 ACR/EULAR criteria for SSc and Forty healthy controls of matched age and sex. The patients were subjected to history taking, clinical examination, skin assessment using the modified Rodnan Skin Score (mRSS), chest x-ray (CXR), pulmonary function test (PFTs), and high resolution com-puted tomography of the chest (HRCT). Routine laboratory tests were conducted in addition to im-munologic tests and an enzyme-linked immunosorbent assay (ELISA) to determine the IL-33 level.

Results:

ILD was found in 23 SSc patients (67.6%); 20 patients had diffuse type while 3 patients had limited type. Non-specific interstitial pneumonia (NSIP) was found in 56.5%, usual interstitial pneumonia (UIP) was found in 21.7%, pleuroparenchymal fibroelastosis (PPFE) was found in 8.7%, and organizing pneumonia (OP) with the mixed pattern was found in 13% of SSc patients. Additionally, the mean IL-33 level in SSc patients was 98±12.7 compared to 66.2±10.6 in the con-trol group (p < 0.001), with ILD patients having a significantly higher level (101.7±13.4) than those without (90.4±6.2), and a strong positive correlation with mRSS.

Conclusion:

Even in asymptomatic patients with SSc, ILD is prevalent, with NSIP being the most common pattern. IL-33 could be considered a potential biomarker for predicting the presence of ILD in SSc patients.
Nano Diosgenin Abates DMBA Induced Renal and Hepatic Toxicities:
Biochemical and Histopathological Evaluation on the Breast Cancer Model
Authors: Sankaran Mirunalini , Vengaimaran Manobharathi , Dhamodharan Kalaiyarasi
Published: August 2022

Background:

: Nature-based pharmaceuticals are now becoming an integral aspect of toxic-free healthcare therapies. Diosgenin (DN), a unique phyto steroidal sapogenin, seems to be explicitly employed as a core ingredient in countless traditional and patented Chinese medicines owing to its epic multilayered therapeutic treasure.

Objective:

The prime intent of the current study was to probe the hepato- and nephro- ameliorating impact of Diosgenin encapsulated chitosan nanoparticles (DN@CS-NPS) on 7,12-dimethylbenz(a)anthracene (DMBA) mediated rat mammary oncogenesis.

Methods:

A single dosage of DMBA (25 mg/kg body weight) was injected to induce breast cancer. Oral administration of DN (10 mg/kg body weight) and DN@CS-NPS (5 mg/kg body weight) was used to medicate DMBA administeredtumor-bearing rats just after the emergence of a tumor. Following the experimental duration, biochemical and histopathological (H&E) analyses have been carried out.

Results:

Here, we noticed that there is an escalated level of liver and kidney biomarkers, phase-I detoxification enzymes, lipid peroxidative marker, total cholesterol (TC), phospholipids (PL), triglycerides (TG), and free fatty acids (FFA), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), total lipase (TL) as well as diminished levels of phase – II detoxification enzymes, enzymatic and non-enzymatic antioxidants, high-density lipoprotein (HDL), lipoprotein lipase (LPL) and lecithin acyltransferase (LCAT) in the plasma, liver and kidney tissues of DMBA-induced rats with renal and hepatic histopathological alterations. Conversely,oral treatment of DN@CS-NPS substantially reduced their tiers to near-normal levels.

Conclusion:

Thus, our observations suggested that DN@CS-NP is an impactful hepato- and nephro- therapeutic agent that might have a significant influence on breast cancer overfree DN.
Synthesis, Molecular Docking and In-silico Admet Screening of New
Benzothiazole-Linked Pyrazole Prototype Derivatives: Validation of
Resistant Strains and their Biological Activity
Authors: Ramadevi Kyatham , Ashok Dommati , Patnaik K.S.K. Rao , Pasha Mohammad Arif , Bathula Raju
Published: August 2022

Background:

The necessity for newer anti-microbial medications with prototypes has
arisen as a result of the prevalence of infections caused by resistant strains of microorganisms.

Objective:

A series of nine novel benzothiazole-linked pyrazole prototype derivatives were synthesized
in multistep reactions and evaluated for anti-microbial and anti-fungal activities. The druglikeness
along with physicochemical properties of synthesized compounds were determined by
docking the ligands with resistant strains.

Methods:

Synthesis of benzothiazole and pyrazole prototype derivatives was carried out by a sequence
of reactions to attain the hydrazine carboxamide derivatives. All the synthesized compounds
were characterized and evaluated for their anti-bacterial and anti-fungal activities against
carbapenem-resistantresistant pseudomonas aeruginosa (CP-PA), carbapenem-resistantresistant
Klebsiella pneumoniae (CP-KP), cephalosporin-resistantclostridium difficile (CR-CD), macrolideresistantresistant
streptococcus pyogenes (MR-SP), Voriconazole-resistant Aspergillus Niger (VRAN)
and Fluconazole-resistant Candida glabrata (FR-CG). Physico-chemical parameters were
done by Medchem DesignerTM software version 5.5 and ADMET parameters by pkCSM online
tool. Furthermore, molecular docking was accomplished with PyRx 0.8 by AutoDock Vina program.

Results:

All the synthesized derivatives were characterized and evaluated for their anti-bacterial
activity, which shows the significant activity of 6i with MIC 36.17 μM on CP-PA, MIC 36.86 μM
on CP-KP, MIC 38.45 μM on CR-CD, and MIC 37.09 μM on MR-SP, with respect to ciprofloxacin
with an average of MIC 32 μM for all resistant bacterial strains. The prototype derivatives
were also evaluated for their anti-fungal activity, in which derivative 6i was found to be significant
with MIC 35.27 μM for VR-AN, MIC 34.78 μM for FR-CG, and MIC values of 25.60 μM and
27.08 μM for Nystatin for all fungal-resistant strains. In-silico predicted parameters for synthesized
prototype derivatives stood to be drug-like.

Conclusion:

From the novel benzothiazole and pyrazole hybrid derivatives, compound 6i was
found to be effective for anti-microbial and anti-fungal drugs and hence can be further explored for
dual activities. Furthermore, derivatization was made to synthesize further potent derivatives for
anti-microbial and anti-fungal treatments.
Maturation of Nephrons by Implanting hPSC-derived Kidney Progenitors
Under Kidney Capsules of Unilaterally Nephrectomized Mice
Authors: Yu Xin , Jiang Shan , Li Kailin , Yang Xianzhen , Zhang Denglu , Du Xiaohang , Feng Kong , Zhao Shengtian
Published: August 2022

Background:

Human pluripotent stem cell (hPSC)-derived kidney organoids may contribute to
disease modeling and the generation of kidney replacement tissues. However, the realization of such applications
requires the induction of hPSCs into functional mature organoids. One of the key questions for
this process is whether a specific vascular system exists for nephrogenesis. Our previous study showed
that short-term (2 weeks) implantation of hPSC-derived organoids below the kidney capsules of unilaterally
nephrectomized and immunodeficient mice resulted in the enlargement of organoids and production
of vascular cells, although signs of maturation were lacking.

Methods:

Organoids were induced for 15 days in vitro and then grafted below kidney capsules of the
same unilaterally nephrectomized immunodeficient mouse model to examine whether medium-term (4
weeks) implantation could improve organoid maturation and vascularization, as evaluated by immunofluorescence
and transmission electron microscopy.

Results:

We demonstrated that after 2–4 weeks of implantation, renal organoids formed host-derived
vascularization and matured without any exogenous vascular endothelial growth factor. Glomerular filtration
barrier maturation was evidenced by glomerular basement membrane deposition, perforated glomerular
endothelial cell development, and apical, basal podocyte polarization. A polarized monolayer epithelium
and extensive brush border were also observed for tubular epithelial cells.

Conclusions:

Our results indicate that the in vivo microenvironment is important for the maturation of
human kidney organoids. Stromal expansion and a reduction of nephron structures were observed following
longer-term (12 weeks) implantation, suggesting effects on off-target cells during the induction process.
Accordingly, induction efficiency and transplantation models should be improved in the future.
Latest in COVID-19 Vaccine 'Candidates' Race
Authors: Atoum Manar Fayiz , Zreig Dalia Abu , Abu Zreig Laith Majed
Published: August 2022

Restoring everyday civil life from the devastating pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can be only by the development of an efficient vaccine. As of
April 12, 2022, 497,960,492 confirmed cases of COVID-19 were reported, including 6,181,850 lives
having been lost worldwide and completely paralyzing the d global economy. Detection of a novel
coronavirus SARS-CoV-2 in Wuhan, in December 2019, and the genetic sequence of SARS-CoV-2
that was published on January 11, 2020, leads to a global race, to prepare for a preventive vaccine. No
single institution can develop a vaccine individually because there are many stages for developing and
producing a successful vaccine. Since this virus threatens the health, the economy, and society the
demand for a fast-track vaccine is understandable. This article tries to give an overview of vaccine
'candidates' development and clinical trials, and it mentions some challenges of using these vaccines
for managing SARS‐CoV‐2.
The Determinants of Treatment Delay and Quality of Life among the
Newly Diagnosed Pulmonary Tuberculosis Patients in Northeastern
Thailand: A Cross-Sectional Study
Authors: Dadras Omid , Thirarattanasunthon Phiman , Wongrith Paleeratana , Kabmuangpak Surasak
Published: August 2022

Background/Objective:

Delays in diagnosing pulmonary tuberculosis (PTB) are linked to
financial difficulties, employment limits, dependency, and symptomatic treatment, all of which have an
impact on the patient's quality of life. Patients' psychological, economic, and social well-being are also
harmed by delayed therapy. The goal of this research was to evaluate sociodemographic characteristics
and quality of life in new pulmonary TB patients and determine the associated factors with delayed TB
diagnosis.

Methods:

This was a cross-sectional study conducted in the Choke Chai Community Hospital, in
Northeastern Thailand between 2016 and 2018. The information related to the patient’s medical history and laboratory tests were gathered from 332 newly diagnosed tuberculosis patients at the hospital's
tuberculosis clinic; of those 15 died and were excluded from the final analysis. Data were analyzed
using SPSS version 17.0.

Results:

The cases included new cases (94%) and those returning to receive treatment after discontinuation of treatment, relapse, or recurrence of the disease (6%). The sample consisted of 68.7% males
and 31.3% females. The average age was 52.7 years (S.D = 15.64). The majority of patients were
married (60.5%), employed (68.6%), received a low income (66.6%), had a history of chronic diseases (73%), drank alcohol (31.7%), and smoked (85.7%). Approximately half of PTB experienced
treatment delay and had a low quality of life (QoL) (46.6%). The treatment delay was associated with
age > 50 years (p <0.05), low self-care (p <0.05), long distance to facility (p <0.05), unavailable caretaker to treat (p <0.05), no caregiver in family (p <0.05), high expenses (p <0.01), and lack of information (p <0.001)

Conclusion:

It appeared that the patients' health-related quality of life could be deteriorated as a result
of pulmonary tuberculosis. Treatment delays can be significantly reduced by changing the understanding of family caregivers, increasing awareness, providing adequate support for patients, and guaranteeing early diagnosis and treatment by implementing an efficient surveillance system.
Emulgel: An Emerging Approach towards Effective Topical Drug Delivery
Authors: Kaushik Dhirender , Pandey Parijat , Minocha Neha , Vashist Neelam , Shah Rashmi , Saini Sapna , Makhija Manish , Purohit Deepika
Published: August 2022

Background:

During the development of the new formulations, the hydrophobic drugs
face many problems leading to poor water solubility and problems related to bioavailability. Topical
drug delivery is a popular and unique process that directs the action of various drugs on the skin for
the treatment and diagnosis of various diseases and disorders such as urticaria, inflammation, rheumatism, etc. This topical release system is usually used to escape the first-pass metabolism. An
emulgel is a superior formulation with combined advantages of both an emulsion and agel. Gel
preparations normally offer earlier drug release than other predictable ointments and creams.

Objective:

The main aim of this review is to deal with the problems associated with the delivery of
hydrophobic drugs and to tackle these problems using an emulgel formulation. Emulgel mainly
provides better stability, prolonged local contact, controlled release of drugs with short half-life, and
better loading capacity.

Methods:

The review was extracted from the searches performed in PubMed, Google Patents, Medline, and Google Scholars, etc. Data from these searches were collected and evaluated to get information about the available literature on the emulgel formulation. The literature obtained was studied
thoroughly as per the requirement of the objective of this review.

Results:

The details of the emulgel formulation, the advantages and disadvantages associated with
it, and the methods for characterization of the formulation are compiled here in this review. Along
with this, some reported patents have also been included in this review to conclude the future of
emulgel formulation in topical drug delivery.

Conclusion:

Emulgel is becoming very popular as a drug delivery system to deliver many antifungal, analgesics, anti-acne, anti-inflammatory drugs, and a number of cosmetics with a wide scope to
be explored further. This review article is motivated by the formulation, characterization, patents,
and biological activities of emulgel formulation.
Ethnopharmacological Insights on Therapeutic Potential of Gloriosa
superba
Authors: Saraf Swarnlata , Tirkey Rakesh , Saraf Shailendra
Published: August 2022

In this modern era, medicinal plants and their phytoconstituents have received keen attention
from researchers due to the various therapeutic implication found in different pharmacological
investigations. Among millions of medicinal plants, Gloriosa superba is one of the therapeutically
important ornamental climbers that has been traditionally used to cure several diseases such as intestinal
worms, skin ailments, and joint pain. Researched data also indicated that the active principle of
Gloriosa superba can produce significant therapeutic action by affecting specific pathophysiological
targets of various ailments. In the last few years, its Crude extract, isolated active principles, and
novel formulations have been claimed for several pharmacological activities such as antidiabetic,
hepatoprotective, anticancer, antimicrobial, anthelmintic, antivenom, analgesic, antiarthritic, etc.
The outcome of pharmacological research confirmed that this herb might be a source of precious
phytochemicals to combat Enigmatic diseases such as cancers, and autoimmune diseases. The present
article gathered the detailed pharmacological explorations on Gloriosa superba to contribute to
the development of strategies for effective delivery of its Phytoconstituents to cure critical diseases.
Graphene-Based Materials for the Removal of Volatile Organic
Compounds
Authors: Tao Huiting , Mei Tao , Cheng Hairong
Published: August 2022

Volatile organic compounds (VOCs) are a group of organic compounds such as aromatic,
aliphatic and chlorinated hydrocarbons, etc. VOCs are emitted into the atmosphere during
the production of adhesives, paints, printing materials, building materials, and their use.
Although several removal approaches have been employed to remove VOCs, researchers have
not stopped exploring new methods and materials for VOCs treatment. Graphene has recently
attracted enormous attention for fundamental research and potential applications due to its large
specific surface area, high mechanical strength and flexibility, and good chemical and thermal
stability. Here we briefly describe the recent progress in graphene-based materials (GBMs) for
applications in VOCs removal. GBMs have been exploited as novel materials in VOC adsorption,
membrane separation, and photocatalysis. Although the issues need to be further studied,
such as biocompatibility, toxicity, and production at low cost, GBMs are promising for VOC
removal, which is the current trends and future perspectives of the field. This mini-review represents
the potential of GBMs for VOC treatment.
A gestão da informação nas PME desafios e oportunidades
Authors: Pessoa Cláudio Roberto Magalhães , Estrela Sónia
Published: August 2022

Influenced by the COVID-19 pandemic, SMEs face unprecedented challenges. Innovation becomes central to facing the crisis and its socio-economic consequences and promoting a sustainable recovery. Aimed in this objeticve, the information and the digital technologies are essential and must be part of the companies response to facing these challenges.This work aims to address information management practices and the transforming potential of technologies in organizations, with a focus on SMEs. Based on a literature review, proposals for actions will be presented to promote efficient andtechnologically mediated information management, which values information at all stages of its life cycle, and support managers in the decision-making process and in the definition of business strategy.
An integrated fuzzy AHP and fuzzy TOPSIS approach in the hotel industry
Authors:   Faculty of Business Administration, University of Labour Social Affairs, Hanoi, Vietnam, et al. Vinh
Published: August 2022

In the context of the COVID-19 epidemic, the turnover intention rate is increasing day by day. The objective of this study is to identify the main factors influencing turnover intention in the Vietnam hospitality industry. The study utilizes the fuzzy AHP and fuzzy TOPSIS model to evaluate the dimensions of the hotel employee turnover intention model. The performance evaluation for employee turnover intention includes Work Itself, Supervision, Coworkers relationships, Salary and Benefit, Career Opportunities, Job Stress, Perceived Risk, and Job Insecurity. These dimensions generate a final evaluation for ranking priority among the employee turnover intention of the proposed model. The importance level of dimensions is evaluated by 17 experts, and decision-making is processed through the fuzzy concept and fuzzy environment. From the critical fuzzy AHP and fuzzy TOPSIS analysis results, the study shows that the most important dimensions of employee turnover intention in the hotel industry model are Salary and Benefit. Moreover, the results indicate that the least important dimensions are the Co-workers' Relationship, Supervision, and Career Opportunities. The second group dimensions that impact employee turnover in the context of the COVID-19 epidemic are Work Itself, Job Stress Perceived Risk, and Job Insecurity. Moreover, this study’s results show that three-star hotels have the highest value of turnover intention; the second is the Four and Five-star hotels, and the third is the Below three-star hotels. The results of the study will help businesses in the fields of hospitality have a more comprehensive view of human resource management activities. Especially, this study provides implications for hotel managers in understanding employee behavior and their turnover intention during the context of the COVID-19 epidemic based on the eight proposed dimensions.
Negative COVID-19 Vaccine Information on Twitter: Content Analysis
Authors: Yiannakoulias Niko , Darlington J Connor , Slavik Catherine E , Benjamin Grant
Published: August 2022

Background

Social media platforms, such as Facebook, Instagram, Twitter, and YouTube, have a role in spreading anti-vaccine opinion and misinformation. Vaccines have been an important component of managing the COVID-19 pandemic, so content that discourages vaccination is generally seen as a concern to public health. However, not all negative information about vaccines is explicitly anti-vaccine, and some of it may be an important part of open communication between public health experts and the community.

Objective

This research aimed to determine the frequency of negative COVID-19 vaccine information on Twitter in the first 4 months of 2021.

Methods

We manually coded 7306 tweets sampled from a large sampling frame of tweets related to COVID-19 and vaccination collected in early 2021. We also coded the geographic location and mentions of specific vaccine producers. We compared the prevalence of anti-vaccine and negative vaccine information over time by author type, geography (United States, United Kingdom, and Canada), and vaccine developer.

Results

We found that 1.8% (131/7306) of tweets were anti-vaccine, but 21% (1533/7306) contained negative vaccine information. The media and government were common sources of negative vaccine information but not anti-vaccine content. Twitter users from the United States generated the plurality of negative vaccine information; however, Twitter users in the United Kingdom were more likely to generate negative vaccine information. Negative vaccine information related to the Oxford/AstraZeneca vaccine was the most common, particularly in March and April 2021.

Conclusions

Overall, the volume of explicit anti-vaccine content on Twitter was small, but negative vaccine information was relatively common and authored by a breadth of Twitter users (including government, medical, and media sources). Negative vaccine information should be distinguished from anti-vaccine content, and its presence on social media could be promoted as evidence of an effective communication system that is honest about the potential negative effects of vaccines while promoting the overall health benefits. However, this content could still contribute to vaccine hesitancy if it is not properly contextualized.
Improving Skin Color Diversity in Cancer Detection: Deep Learning Approach
Authors: Rezk Eman , Eltorki Mohamed , El-Dakhakhni Wael
Published: August 2022

Background

The lack of dark skin images in pathologic skin lesions in dermatology resources hinders the accurate diagnosis of skin lesions in people of color. Artificial intelligence applications have further disadvantaged people of color because those applications are mainly trained with light skin color images.

Objective

The aim of this study is to develop a deep learning approach that generates realistic images of darker skin colors to improve dermatology data diversity for various malignant and benign lesions.

Methods

We collected skin clinical images for common malignant and benign skin conditions from DermNet NZ, the International Skin Imaging Collaboration, and Dermatology Atlas. Two deep learning methods, style transfer (ST) and deep blending (DB), were utilized to generate images with darker skin colors using the lighter skin images. The generated images were evaluated quantitively and qualitatively. Furthermore, a convolutional neural network (CNN) was trained using the generated images to assess the latter’s effect on skin lesion classification accuracy.

Results

Image quality assessment showed that the ST method outperformed DB, as the former achieved a lower loss of realism score of 0.23 (95% CI 0.19-0.27) compared to 0.63 (95% CI 0.59-0.67) for the DB method. In addition, ST achieved a higher disease presentation with a similarity score of 0.44 (95% CI 0.40-0.49) compared to 0.17 (95% CI 0.14-0.21) for the DB method. The qualitative assessment completed on masked participants indicated that ST-generated images exhibited high realism, whereby 62.2% (1511/2430) of the votes for the generated images were classified as real. Eight dermatologists correctly diagnosed the lesions in the generated images with an average rate of 0.75 (360 correct diagnoses out of 480) for several malignant and benign lesions. Finally, the classification accuracy and the area under the curve (AUC) of the model when considering the generated images were 0.76 (95% CI 0.72-0.79) and 0.72 (95% CI 0.67-0.77), respectively, compared to the accuracy of 0.56 (95% CI 0.52-0.60) and AUC of 0.63 (95% CI 0.58-0.68) for the model without considering the generated images.

Conclusions

Deep learning approaches can generate realistic skin lesion images that improve the skin color diversity of dermatology atlases. The diversified image bank, utilized herein to train a CNN, demonstrates the potential of developing generalizable artificial intelligence skin cancer diagnosis applications.

International Registered Report Identifier (IRRID)

RR2-10.2196/34896
Evaluation of a Tailored Digital Literacy Intervention in Affordable Older-Adult Housing: Case Study
Authors: DeLange Martinez Pauline , Espinoza Giacinto Rebeca , Henderson Stuart , Lindeman David
Published: August 2022

Background

Older age, low socioeconomic status, living alone, and low English proficiency are independent factors associated with low information communication technology (ICT) use. Evidence-based interventions are needed to increase digital access and literacy among underrepresented groups.

Objective

This study aimed to increase the understanding of factors influencing ICT adoption and sustainable resources for training and support in affordable older-adult housing.

Methods

Broadband, tablet computers, training, and support were offered at 1 affordable older-adult housing community. Three 60-minute classes covered device basics, Google Translate, YouTube, and Zoom; in-language user guides were provided. Resident Ambassadors offered weekly in-language tech support. Mixed methods evaluation included surveys at entry, 30 days, and 90 days and key informant interviews.

Results

Overall, 72% (N=76) of residents participated. The average age was 78 (SD 8) years, and the participants were primarily Asian (62%), lived alone (68%), and had low English proficiency (65%). About half (49%) of the participants had less than a high school degree. Reasons to decline initial participation included: already owned another device, visual or cognitive challenges, or unwillingness to complete surveys. Of the participants, 89% attended at least 1 class and 37% attended all 3 classes. Over 90% of participants found the classes helpful, 87% found the user guide helpful, and 49% received help from a neighbor. At 30 and 90 days, 82% of the participants reported using their tablet at least twice per week for various activities. However, over half of participants reported the tablet was difficult to learn, and from 30 to 90 days, confusion and the fear of making mistakes when using the tablet slightly increased.

Conclusions

Overall, participants reported high satisfaction with the devices and tech support, although the decreasing comfort with technology over time indicates a need for additional training and ongoing support. This case study provides a model to increase ICT use among older adults in affordable older-adult housing communities.
Digital Health for Vulnerable Populations: From Co-design to Scaling and Replication
Authors: Berkowitz Gale
Published: August 2022

Background

The COVID-19 pandemic has made it clear that technology access, digital literacy, and telehealth access have become more crucial than ever before. At the Center for Information Technology Research in the Interest of Society (CITRIS) at the University of California, 2 projects are focused on communities have the least access to quality health care services, including low-income workers in rural areas as well as low-income older adults in their community.

Objective

Co-designed technology innovation is a core competency of CITRIS Health. This presentation will focus on 2 of CITRIS Health’s co-designed signature programs: ACTIVATE and Lighthouse. Co-designed innovations have the intended outcomes of improving access to technology, increasing technology literacy, and ultimately improving health outcomes.

Methods

Co-design refers to a participatory approach to designing solutions, in which community members are treated as equal collaborators in the design process—they give feedback, and they try out devices. It is part of an innovation process. Key components of a co-design process involve the following: intentionally involving users in designing solutions, postponing design decisions until after gathering feedback, synthesizing feedback from participants into insights, and developing solutions based on feedback.

Results

Both projects have undergone formal evaluations to assess the process of implementation as well as outcomes. Additionally, each project has a systematic process for monitoring its own implementation and key metrics. Common near-term outcomes include positive feedback from co-designers about the inclusivity of the design progress and optimism that technology selections, training, and interventions will lead to the intended outcomes.

Conclusions

Ultimately, the intention of these co-designed innovations is to create models that are feasible and sustainable. They will provide a roadmap for both public and private partners, setting a gold standard in California and across the nation.
Test model for database architectures: an assessment for job search engine systems
Authors: Bernal Mary Carlota , Molina Yeimer
Published: August 2022

Data is a fundamental part of information and management systems; thus, controlling its complexity is an essential step nowadays. NoSQL databases adopt new approaches to data management differing from relational structures. For this study, two database systems are considered, MongoDB as a NoSQL data storage model and PostgreSQL as a relational data model, they are compared and evaluated on a job search system. For this purpose, a dataset was defined, and its representation was constructed in databases based on each technology. This process allowed the data modeling in terms of the best practices, then, the development of a test plan prepared the environment for the determination of the comparison metrics of both databases under the methodology specified by the International Software Testing Qualifications Board (ISTQB) and the types of database testing. This study determined that the SQL schema provides greater functionality, that ensures the support of transactions and data integrity, the opposite happened with the NoSQL schemas, resulting in more efficient but lacking functionalities that are characteristic and required for data representation of a consistent system.
Circularly Polarized UWB Antenna with Question Mark Shaped Patch for GPR Applications
Authors: Chaabane Abdelhalim , Guerroui Mohammed
Published: August 2022

A novel Circularly Polarized (CP) Ultra Wideband (UWB) antenna for Ground Penetrating Radar (GPR) applications is presented and discussed in this paper. The proposed antenna is constructed by a question mark shaped radiating patch and a truncated ground plane. A prototype of the designed antenna is fabricated on the FR4-substrate with an overall volume of 0.7λ0×0.793λ0×0.035λ0 at 7 GHz. The simulated results show that the designed antenna has an Impedance Bandwidth (IBW) ranging from 3.14 GHz to 11.88 GHz (116.38%). The CP feature is analyzed and discussed confirming that the antenna maintains a CP radiation characteristic in a broadband with a 3-dB Axial Ratio Bandwidth (ARBW) ranging from 4.13 GHz to 9.28 GHz (76.81%). The measurements were done by utilizing a well calibrated R&S®ZNB Vector Network Analyzer indicating that the fabricated prototype has an IBW nearly ranging from 3.47 GHz to 12.11GHz (110.91%). The results are favorable that ensure the usefulness of this antenna for GPR applications.
Isolation and Identification of Multi-Drug Resistant (MDR) Pathogens from Patients with Urinary Tract Infection (UTI) in Dhaka City, Bangladesh
Authors: Khatun Fatema , Kumar Naresh , Khushboo  , Abony Maruf , Datta Suvamoy
Published: August 2022

Urinary tract infection (UTI) is the leading cause of death among patients and majority of people visiting the hospital worldwide. In the current quantitative study, urine samples were obtained using sterile method and 100 isolates, including 60 Escherichia coli, 28 Klebsiella sp., and 12 Proteus sp., were investigated in a laboratory. Current study showed that E. coli 60/100 (60%) was the most common cause of UTI followed by Klebsiella sp. 28/100 (28%) and Proteus sp. 12/100 (12%). Cefotaxime (86.67% sensitive) was found to be the best drug for treating infections with E. coli, ceftazidime (100% sensitive) for infections with Klebsiella sp., and imipenem and levofloxacin (100% sensitive) for infections with Proteus sp. Overall, 51% of the isolated strains showed high multidrug resistance (MDR). Because of the alarming increase in extensively drug-resistant and MDR uropathogens, which is a concern in public health, the rational use of antimicrobial therapy should be implemented.
Modern Mechanism of Image Augmentation
Authors: Tyagi Shikha , Singh Dharamveer , Vakil Mohd
Published: August 2022

Abstract: In this theory a cutting edge component of picture increase is proposed. This system amalgamates two extremely well known capabilities of increase, "Wavelet disintegration and histogram molding and moving". This component increases of business pictures and additionally regular pictures. This computation presents unique image (grayscale and shading picture) of introductory moldy wallet coefficient. At that point these coefficients separated by worldwide thresholding. This edge is ascertained by histogram molding and moving system with variety of coefficient K estimation. Opposite wavelet transfigure of separated and remold coefficients of the picture concede the reproduction of a unique picture.
Characterization and Quantification of Solid waste in Gram Panchayats of U.P.
Authors: Rathaur Sudheer Singh , Shrivastava J. B. , Patel Anand
Published: August 2022

Abstract: Efficient and effective handling of solid waste in gram panchayats of Uttar Pradesh starts with determining the character and quantity of the waste, for which we select two city from central region and west region (1. Lucknow, 2. Gorakhpur). In the above districts 2 Gram Panchayats of each district were surveyed. From the selected Gram Panchayat, the sample was as under: (1) Gram Panchayat with more than 10000 population 300 households were surveyed; (2) Gram Panchayat with 5000-10000 population 150 households were surveyed; (3) Gram Panchayat with 2000-5000 population 100 households were surveyed; (4) Gram Panchayat with less than 2000 population 50 households were surveyed. The selection of Gram Panchayats was done in consultation with the District authorities. And in order to get the data of waste generated and its type at the weekly markets, survey of one weekly market was done at each District. The waste generated in gram panchayats was categorized under 4 major heads (Bio-degradable waste, Recyclable waste, Hazardous waste, Inert waste). In the study we found that most of the waste in gram panchayats are Bio- degradable in nature (58.01%) and Inert waste (22.50%) is at second place and recyclable waste (16.52%) is at number 3 and every type waste can be managed but there is no proper management of solid waste at gram panchayat level. We also suggest some effective way to manage the solid waste at gram panchayat level in U.P
Car Price Prediction Using Machine Learning Algorithms
Authors: Reddy B V Raghurami , Sree Dr. K. Shanthi
Published: August 2022

Abstract: Machine learning(ML) is an area of a AI that has been a key component of digitization solutions that have attracted much recognition in the digital arena. ML is used everywhere from automating and do heavy tasks to offering intelligent insights in every industry to benefit from it. The current world already using the devices that are suitable these problems. For example, a wearable fitness tracker like Smart Band or a smart home assistant like Alexa, Google Home. However, there are many more examples of machine learning in use. In this project the task is to find out price of a used car. The cars dataset taken from Kaggle, where dataset contains used car details (variables), Our task is to finds out which variables are significant in predicting the price of a used car and how well these variables are important in predicting the price of a car. For this task we were using machine learning algorithms are linear regression, ridge regression, lasso regression, K-Nearest Neighbors (KNN) regressor, random forest regressor, bagging regressor, Adaboost regressor, and XGBoost.
Psychometric properties of the Chinese version of the COVID-19 Phobia Scale among Chinese undergraduates
Authors: Chu Kequn , Zheng Yue , Zhu Fengshu
Published: August 2022

We examined the validity and reliability of the COVID-19 Phobia Scale (C19P-S) in the Chinese cultural context. We translated the original version of the C19P-S into Chinese and assessed its structure through exploratory factor analysis, confirmatory factor analysis, internal consistency
reliability tests, and test–retest reliability tests. The Chinese version of the C19P-S comprises 20 items classified into four dimensions: psychological, psychosomatic, economic, and social. According to the statistical results, the scale has adequate psychometric properties in the
Chinese cultural context and, therefore, can be used to assess the COVID-19 phobia of Chinese undergraduates.
Psychometric properties of the Barkley Adult Attention Deficit Hyperactivity Disorder Rating Scale-IV in the Korean population
Authors: Yoo Hyunkyung , Cho Sungkun , Kim Kiho
Published: August 2022

Discriminating attention-related symptoms is a key factor for the appropriate diagnosis of attention deficit hyperactivity disorder (ADHD) and sluggish cognitive tempo (SCT). The Barkley Adult Attention Deficit Hyperactivity Disorder Rating Scale-IV (BAARS-IV) is the most widely used
tool to measure such symptoms. This study investigated the psychometric properties of the BAARS-IV with a sample of 771 participants in the Korean population. We identified a five-factor model for measuring ADHD and SCT, and determined the scale was appropriate for use in the Korean population.
Sustained attention (SA) was a unique factor of the Korean version of the BAARSIV. Internal consistency was good and the positive association between the BAARS-IV and an alternative measure of depression/anxiety supported the scale's concurrent validity. To conclude, a cautious approach is
needed when applying the BAARS-IV in different cultural contexts.
PRAKTEK RE-UPLOAD VIDEO OLEH YOUTUBER DAN KEABSAHAN PEMBAYARANNYA
Authors: Fazlur Rahman
Published: August 2022

Youtube adalah sebuah situs web berbagi video yang dibuat oleh tiga mantan karyawan Paypal pada Februari 2005, situs ini memungkinkan Pengguna mengunggah, menonton, dan berbagi video. Perusahaan ini berkantor di San Bruno, California, dan memakai teknologi Adobe Flash Video dan HTML5 untuk menampilkan berbagai macam konten video buatan pengguna, termasuk klip film, klip TV, dan video musik. Selain itu ada pula konten amatir seperti blog video, video orisinil pendek, dan video pendidikan. Youtube saat ini telah menyediakan dua jenis lisensi di situsnya, yaitu perlindungan Hak Cipta (tidak boleh di re-upload oleh pihak lain) dan Perlindungan Creative Commons BY (CC BY) (boleh di re-upload oleh pihak lain). Meskipun demikian bukan berarti tanpa masalah, salah satu masalah yang masih terjadi di Youtube adalah banyaknya kasus-kasus pelanggaran hak cipta di situsnya, seperti praktek re-upload video disini misalnya.

Penelitian ini mengkaji bagaimana Keabsahan penghasilan yang diperoleh  dari aktivitas re-upload video di Youtube ditinjau dari Perspektif Hak Ibtikar dalam Islam dan Fiqh Muamalah. Penelitian skripsi ini termasuk jenis penelitian Kepustakaan (Library Research), yaitu pengumpulan data dengan menggunakan studi penelaahan terhadap buku-buku, jurnal, dokumen-dokumen cetak, dan dari situs yang ada di internet. Hasil dari penelitian yang dilakukan penulis dalam skripsi ini adalah haram hukumnya praktek re-upload video yang yang dilakukan semata-mata untuk mendapatkan keuntungan pribadi tanpa memberikan royalti kepada produser/label terkait, dengan kata lain perbuatan tersebut sama halnya dengan seorang pedagang menjual barang milik orang lain tanpa seizin pemiliknya atau menjual barang hasil curian, hal ini jelas merugikan pihak pencipta atau pemegang hak cipta karena video yang beredar di youtube tersebut tidak diberikan izin oleh pihak pencipta video untuk menyebarkan ciptaannya tersebut kepada masyarakat dengan menggunakan media situs Youtube. Dalam Islam hak cipta dikenal dengan istilah Haq Ibtikar yaitu hak khusus yang melekat pada pemilik video asli dan bagian dari harta kekayaan intelektual baik yang bersifat materil maupun immateril sehingga harus dilindungi secara hukum. Islam sangat menghargai hak cipta sebagai hak kekayaan pribadi sehingga hak ibtikar  ini digolongkan, kedalam Maqashid Syariah untuk menjaga eksistensi kepemilikan harta setiap muslim. Setiap harta yang dihasilkan dari perbuatan re-upload Video di dalam Islam dan Fiqh Muamalah adalah haram hukumnya, karena termasuk dalam melanggar hak-hak orang lain secara batil
PERAN PEMERINTAH TERHADAP PENINGKATAN PRODUKSI GARAM DI GAMPONG CEBREK KABUPATEN PIDIE MENURUT HUKUM ISLAM
Authors: Armaya Halidasari  , Arifin Abdullah
Published: August 2022

Produksi merupakan pekerjaan berjenjang yang memerlukan kesungguhan manusia, pengorbanan yang besar, dan kekuatan yang terpusat dalam lingkungan tertentu untuk mewujudkan daya guna material dan spiritual. Produksi merupakan faktor utama kegiatan ekonomi. Di Kabupaten Pidie, terdapat usaha produksi garam yang terletak di gampong Cebrek, dalam menjalankan usaha tersebut tidak terlepas dari masalah yang dihadapi. Tujuan dari penelitian ini untuk melihat kendala apa yang di hadapi petani garam dan bagaimana peran pemerintah dalam mengatasi kendala tersebut, serta bagaimana perspektif ekonomi Islam terhadap peran pemerintah pada kegiatan produksi garam. Peran yang dilakukan oleh pemerintah harus sejalan dengan aturan syari’at. Adapun metode yang digunakan dalam penelitian ini adalah metode kualitatif. Hasil penelitian mendapati bahwa kendala yang di hadapi oleh petani garam di gampong Cebrek harus segera ditangani oleh dinas terkait demi kelancaran produksi dan menghasilkan garam dengan kualitas terbaik. Adapun pemerintah yang terkait dalam usaha produksi garam ini adalah Dinas Kelautan dan Perikanan. Berdasarkan hasil penelitian, selama ini dinas kelautan dan perikanan belum sepenuhnya menjalankan kewajiban yang harus dilakukan terhadap peningkatan produksi garam di Gampong Cebrek. Dalam perspektif ekonomi Islam, pemerintah yang memiliki kekuasaan dalam mengatur rakyat termasuk dalam aktivitas ekonomi, harus dapat memegang kokoh pada landasan Al-Qur’an dan Sunnah dalam menjalankan kewenangannya berlaku adil agar sesuai dengan aturan dan norma yang berlaku dalam bingkai Syari’ah.
ANALISIS PERJANJIAN PRE-ORDER PADA TRANSAKSI JUAL BELI ONLINE DAN KONSEKUENSI HUKUMNYA BAGI PARA PIHAK MENURUT HUKUM POSITIF DAN HUKUM ISLAM
Authors: Riadhus Sholihin  , Rauzatun Zannah
Published: August 2022

Fenomena jual beli online semakin berkembang pesat sehingga timbul berbagai sistem dalam melakukan transaksi jual beli, salah satunya pre-order yaitu sistem pembelian barang dengan memesan dan membayar terlebih dahulu sebelum produksi dimulai, dengan tenggang waktu tunggu sampai barang tersedia. Permasalahan dalam penelitian ini adalah bagaimana pelaksanaan perjanjian pre-order dalam transaksi jual beli online pada onlineshop, bagaimana bentuk perlindungan hukum bagi para pihak dalam perjanjian pre-order transaksi jual beli online pada onlineshop dan bagaimana keabsahan perjanjian pre-order dalam transaksi jual beli online pada onlineshop di Kota Banda Aceh menurut hukum positif dan hukum Islam. Dalam penelitian ini penulis menggunakan metode deskriptif analisis berdasarkan data yang diperoleh dari hasil wawancara dengan pelaku usaha onlineshop dan konsumennya. Hasil dari penelitian ini adalah Perjanjian pre-order dalam transaksi jual beli online pada onlineshop di Kota Banda Aceh dilaksanakan pada marketplace shopee. Diawali dengan perjanjian persetujuan dari shopee yang harus disepakati oleh para pihak baik penjual maupun pembeli. Kemudian proses transaksi jual beli berlangsung mulai dari pemesanan barang hingga barang tersebut sampai. Perlindungan hukum bagi para pihak yang dirugikan didasarkan pada Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen. Ada 3 bentuk perlindungan hukum yang diberikan shopee terhadap konsumen yaitu perlindungan hukum preventif, perlindungan hukum terhadap penipuan, dan penyelesaian sengketa. Perjanjian pre-order dalam jual beli online di Kota Banda Aceh belum memenuhi keabsahan perjanjian menurut hukum positif dan hukum Islam dikarenakan pelaksanaan perjanjian belum memenuhi syarat sah perjanjian dalam KUH Perdata serta ketentuan berdasarkan Fatwa Dewan Syari’ah Nasional No:06/DSN-MUI/IV/2000 tentang Jual Beli Istisnā’.
IBU SEBAGAI HYPNOTIST TERHEBAT DI DUNIA
Authors: Salami Salami
Published: August 2022

Ibu adalah orang yang paling pertama bersentuhan langsung secara fisik dan

psikis dengan anaknya. Interaksi seorang ibu dengan anaknya sudah dimulai

sejak seorang anak masih berada dalam kandungan. Oleh karena itu apapun

yang dirasakan dan dilakukan oleh seorang ibu, positif atau negatif, akan

langsung berdampak bagi seorang anak sejak mulai dalam kandungan sampai

anak dewasa. Penelitian terus berkembang tentang pengaruh seorang ibu

terhadap tumbuh kembang seorang anak, terutama perkembangan

psikologisnya. Oleh karena itu seorang ibu harus terus belajar tentang berbagai

ilmu yang terkait dengan pendidikan anak sehingga dia hanya memberikan

dampak positif dan menghindari dampak negatif bagi pertumbuhan dan

perkembangan anaknya. Karena ibu mampu meprogram pikiran anaknya

dalam berbagai interaksi, maka ibu disebut sebagai penghipnosis (hypnotist)

hebat di dunia.