bluuebunny/crossref_metadata_2025 huggingface dataset:
Forecasting business innovative activity using indicators of innovative potential of personnel
Authors: Yarushkina Nataliya Anatolievna , Matyugina Eleonora Grigorievna
Published: September 2021

The article highlights the results of studying and forecasting the innovative potential of personnel, which, when a number of conditions are met, is embodied in innovative activity characterized by the rates of rationalization efforts. Russian Railways, JSC is one of the first companies to develop a regulatory framework arranging the innovative activities and relations arising in the course of development and use of rationalization proposals, as well as formalizing the innovative activities of personnel, whose activity served as a factual basis of the research. There have been emphasized the significant components of the employees’ innovation activity, the development of which is the prerogative of the company. The purposeful activity of Russian Railways, JSC in training the employees for inclusion in the process of generating proposals was noted. The dynamics of the innovative proposals and their authors is analyzed. The change in the obtained economic effect per one innovative proposal has been investigated. Modeling the dependence of the used rationalization proposals on the number of authors who submitted proposals has been carried out. The assessment of the accuracy and adequacy of the constructed regression equation is given, the absence of cointegration of the considered time series is shown, which gives grounds to use the constructed model of dependence of indicators of the innovative potential of the company’s personnel for making forecasts. Point and interval forecasting of the factor attribute of the predictive model of the number of authors who submitted rationalization proposals was performed using the linear trend equation, the quality level of which as a whole, as well as the statistical significance of the equation parameters were assessed using Fisherʼs F-test and Studentʼs t-test. There has been proved the significance of forecasting the indicators of rationalization activity as indicators of the innovative activity of personnel in making managerial decisions by the company in relation to its intensification is shown; substantiated the need to take into account the structural and infrastructural components in the construction of predictive models.
Concept of corporate digital responsibility in mesologistic systems management
Authors: Gviliya Natalya Alekseevna
Published: September 2021

The article is devoted to studying the impact of digitalization of logistics processes in corporate structures within the framework of the concept of sustainable development, which allows to highlight the need to develop corporate responsibility for the result of technology implementation and to form the concept of corporate digital responsibility. The methodological basis of the research includes the theoretical provisions of strategic management, corporate logistics, corporate social responsibility, concept of sustainable development and Industry 4.0, functional and strategic convergence of scientific theories of logistics, supply chain management, management and information technology. The instrumental and methodological apparatus is based on the application of a systematic method of research of logistics systems and the specifics of their transformation in the process of transition to the digital economy, including the analysis and synthesis of the empirical base of the study. General scientific methods were used: generalization of theoretical material and factual data of corporate logistics systems and ecosystems; the method of functional analysis; modeling; tools for graphical interpretation of fixed dependencies. There has been introduced a new concept of corporate digital responsibility, its specific nature and conceptualization have been examined. In defining corporate digital responsibility, there has been suggested focusing on ethical issues that are unique to the digital context. The key related stakeholders and key milestones to be addressed are identified, the creation, operation, impact assessment, and refinement of technology and data within the mesologistic systems management framework. Taken together, the results of the study can be useful for organizations as practical recommendations for specific departments in the corporation for translating strategic decisions on digital responsibility.
iPS Cells: Don’t Forget about the Soft Impacts
Authors:   PhD-student, University Medical Center Utrecht, The Netherlands, Assen Lars ,   E-mail: l.s.assen@umcutrecht.nl, Bredenoord Annelien ,   University Medical Centre Utrecht, The Netherlands, Jongsma Karin ,   University Medical Centre Utrecht, The Netherlands, Tryfonidou Marianna ,   University Utrecht, The Netherlands, Isasi Rosario ,   Miller School of Medicine, Miami, United States of America
Published: September 2021

"Induced pluripotent stem cells (iPSCs) have been praised for overcoming some of the ethical challenges of embryonic stem cell research, including oocyte donation for research and the destruction of human embryos. However, iPSC-research and iPSC-based interventions are not morally neutral alternatives and have their own ethical implications that are not fully understood yet. While there is some understanding of ethical issues surrounding the derivation, storage and use of human tissue, there is less understanding of how iPSC-research affects our society and morality. Consequentially, it is difficult to fully anticipate those implications. The notion of hard and soft impacts could benefit the understanding and anticipation of ethical implications of iPSC-research and interventions. Hard impacts are those direct physical and financial effects of iPSCs that are quantifiable and measurable. So-called soft impacts have a different focus. They consider how a technology or intervention affects our psychology, societal structures, morality and our behavior, hereby influencing the uptake, effects and evaluation of technology. So far, academic literature and researchers focus primarily on hard impacts of iPSC-research. Soft impacts are similarly important and therefore require more academic and regulatory attention. This talk focuses upon these understudied aspects of iPSC-research and technology. The goal is to show that for researchers and ethicists it is important to become aware of the soft impacts of iPSC-research and technology. This awareness could contribute to a broader understanding of the social value of stem cell research, anticipating ethical challenges of iPSC-research and in formulating new virtues for stem cell researchers. "
Clinical Trials Involving Minors: The Role of the Ethics Consultation in Avoiding Therapeutic Misconception
Authors:   PhD Student, University of Insubria, Varese, Italy, Ceruti Silvia ,   E-mail: ceruti.silvia@gmail.com
Published: September 2021

"Therapeutic Misconception (TM) occurs when clinical trial participants believe that the central purpose of the trial is therapeutic and that they will personally benefit from participation. If individuals who are entitled to consent to participation in a specific clinical trial do not understand that the defining purpose of clinical research is to produce generalizable knowledge, regardless of whether the subjects enrolled may potentially benefit from the intervention under study, this false belief may motivate them to participate, and in extreme cases may disqualify their consent. TM is especially frequent in fields in which the patients are highly vulnerable, such as when they are children and require parental consent. The informed consent is an essential ethical prerequisite before enrolling each and every participant in research that should protect patients through a process of dialog about a planned course of action. We argue that Ethics Consultant’s competencies may be crucial in avoiding TM: The Ethics Consultant should be involved in neonatal and paediatric clinical trials in order to face the unique vulnerability of children as research subjects, and to ensure that parental consent procedures are rigorously managed, enhancing recruitment in research trials in the context of fully understood consent. "
Could Covid-19 Challenge Trials be Reasonably Rejected as Morally Impermissible? A Contractualist Perspective
Authors:   Assistant Professor, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Department of Medical Education, Chair of Abilities - Human Sciences, Crișan Horațiu Traian ,   E-mail: horatiu.crisan@umfcluj.ro
Published: September 2021

"In challenge experiments, research subjects are exposed to a pathogen agent in order to study a certain disease, and/or to determine the amount of infecting dosage, and/or to test the efficacy of a vaccine. General discussions on challenge experiments have already been undertaken in contemporary medical research and these uptakes generate an ongoing debate about their ethical permissibility. Recently, these research issues have focused also on Covid-19 challenge trials in which the determination of the infecting dosage, the efficacy test of vaccines and the immune response of people who already passed through the disease have been investigated. In my paper, I will offer a philosophical perspective on these specific trials, based on T. M. Scanlon’s version of contractualism. I will start by briefly presenting the features of Scanlon’s contractualist ethical theory and by formulating the moral principles which could support Covid-19 challenge trials. Thereafter, I will search for reasonable rejections in order to be able to establish whether this type of trials is ethically permissible or not. In the second part of my presentation, I will tackle Scanlon’s view on medical experimentation in general and his subsequent distinction between direct harm and accidental harm, in order to argue for its relevance for the case of Covid-19 challenge trials. I will demonstrate that according to the general contractualist perspective, these trials are not ethically justifiable. Finally, I will search for a consolidation of my argument, by considering a tighter version of contractualism to be applied to the domain of medical research. Research reported in this presentation was supported by Fogarty International Center of the National Institutes of Health under award number R25TW01051. "
Tolerance: Too Little for Clinical Ethics in a Pluralist Society?
Authors:   Ph.D., Icahn School of Medicine at Mount Sinai, New York, USA, Cummins Paul J. ,   E-mail: paul.cummins@mssm.edu, Nicoli Federico ,   Insubria University, Varese, Italy
Published: September 2021

"Virtually all Western societies embrace liberalism as a political and moral; it emphasizes individual rights and liberty, democracy, autonomy, limited government, consent, pluralism, and tolerance. Clinical ethics in these societies reflects those priorities. Human migration has made Western societies more diverse and expanded the plurality of values represented within them. As a consequence, clinical ethics consultants (CEC) have encountered cases which reflect a clash between the liberal values of contemporary medical ethics and non-liberal values of patients. Because CECs are steeped in liberalism, their default attitude toward the values outside of that tradition will be tolerance. This paper will argue that because tolerance implicitly contains a judgment of inferiority to other values, it is the wrong attitude for CECs to adopt towards parties whose fundamental values clash with medical ethics. In such cases, this attitude can disrespect to the holders of the values, endorse a consequentialist compromise of values, and leave medical professionals prone to moral distress. Agonism democracy is a political philosophy that accepts that values conflicts are inevitable, and there will be winners and losers from them. It aims to channel this conflict positively by promoting a process marked by openness to questioning fundamental values and genuine consideration of (even contrary) alternate values. As an alternative to tolerance, this paper will explore if cultivating an attitude of agonism can be a better disposition for CECs in such cases. It will use a case study to compare the results of the two approaches in cases of fundamental values clash. "
KONSEP SISTEM EKONOMI KERAKYATAN DALAM PEMBERDAYAAN UMKM INDONESIA
Authors: Styaningrum Farida
Published: September 2021

Sistem Ekonomi Kerakyatan berasaskan pada kekeluargaan, demokratis dan berkeadilan mendorong rakyat Indonesia untuk ikut serta dalam kepemilikan modal dan sebagai pengendali perekonomian. Usaha mikro, kecil, dan menengah (UMKM) merupakan perwujudan dari sistem Ekonomi Kerakyatan di Indonesia yang mayoritas kepemilikan modal oleh masyarakat menengah. Penelitian dilakukan dengan metode studi literature yang berfokus pada konsep sistem Ekonomi Kerakyatan untuk pemberdayaan UMKM di Indonesia. Dalam era otonomi daerah saat ini, sistem Ekonomi Kerakyatan untuk pemberdayaan UMKM dapat diwujudkan dengan mengangkat potensi lokal agar dapat meningkatkan kemandirian ekonomi daerah. Pemberdayaan UMKM yang berdasar pada sistem Ekonomi Kerakyatan sudah harus menjadi prioritas dalam meningkatkan pembangunan nasional, karena terbukti sektor UMKM mampu bertahan pada setiap perubahan iklim ekonomi termasuk dalam kondisi krisis ekonomi. Pemberdayaan UMKM dapat terlaksana apabila terdapat kerjasama yang baik antara pemerintah, masyarakat, pengusaha UMKM, stakeholder dan pihak-pihak swasta. Dengan landasan semangat ideologi sistem Ekonomi Kerakyatan dari beberapa pihak tersebut, maka akan meningkatkan perekonomian daerah serta nasional Indonesia.
PENGARUH PEMBERDAYAAN MASYARAKAT TERHADAP COMMUNITY BASED TOURISM DAN KESEJAHTERAAN MASYARAKAT PADA CEKING RICE TERRACE, TEGALLALANG
Authors: Suryawan Adi , Utama Made Suyana
Published: September 2021

This study aims to determine the effect of community empowerment on community based tourism (CBT) and community welfare at the Ceking Rice Terrace tourist attraction, Tegallalang, Gianyar. The sample of this study were 88 people through simple random sampling. The data collection method used was questionnaire distribution. The data analysis technique used is the Structural Equation Model (SEM) with the Partial Least Square (PLS) approach. The results showed that community empowerment had a positive effect on CBT and community welfare, community empowerment and CBT had a positive effect on community welfare, and CBT was able to positively mediate the effect of empowerment on community welfare. Community empowerment should be further improved because there are still many people who do not participate in the development of tourist objects, especially Ceking Rice Terrace, which causes economic disparities in Tegallalang Village and there are still people who do not have a job, or in other words, the welfare of the community has not yet been realized.
UJI DAYA HAMBAT ASAP CAIR TEMPURUNG KELAPA (Cocos nucifera L.) TERHADAP PERTUMBUHAN Escherichia coli SECARA In Vitro
Authors: Lumban Tobing Rachel Daniella Dinda Maria , Defiani Made Ria , Susun Parwanayoni Ni Made
Published: September 2021

Daging yang terkontaminasi bakteri berpotensi menimbulkan penyakit yang berbahaya apabila dikonsumsi manusia. Salah  satu  kuman  khususnya bakteri  yang  mencemari  daging  baik  yang  mentah  atau  daging dengan  proses  pematangan  yang  kurang  sempurna  adalah Escherichia coli. Oleh sebab itu, E. coli perlu diminimalisir dengan cara menghambat pertumbuhannya. Salah satu cara alami untuk menghambat pertumbuhan E. coli adalah dengan uji antibakteri menggunakan asap cair. Asap cair dapat diperoleh melalui proses pirolisis dari berbagai biomassa yang mengandung selulosa, hemiselulosa, dan lignin seperti pada tempurung kelapa (Cocos nucifera L.). Asap cair mengandung senyawa fenol dan asam yang bersifat antimikroba dan antioksidan. Penelitian ini menggunakan metode sumur difusi. Analisis data menggunakan Rancangan Acak Lengkap (RAL) dengan uji ragam (ANOVA) apabila data memiliki beda nyata pada taraf uji 5% (P?5) maka dilanjutjan uji Duncan. Asap cair tempurung kelapa mampu menghambat pertumbuhan E.coli yang ditandai dengan terbentuknya zona hambat. Konsentrasi asap cair tempurung kelapa yang efektif menghambat pertumbuhan E. coli adalah konsentrasi 50% dengan diameter zona hambat 16,66 mm dan MIC pada konsentrasi 10% dengan diameter zona hambat 9,33 mm. Hasil uji fitokimia asap cair tempurung kelapa positif mengandung senyawa fenol, flavonoid, triterpenoid, dan saponin serta kadar fenol 2,403% dan kadar saponin 5,50%.
BAKTERI ASAM LAKTAT BERMANFAAT DALAM KEFIR DAN PERANNYA DALAM MENINGKATKAN KESEHATAN SALURAN PENCERNAAN
Authors: Prayoga I Putu Aditya , Ramona Yan , Suaskara Ida Bagus Made
Published: September 2021

ABSTRAK

Kefir merupakan produk fermentasi susu yang melibatkan berbagai macam bakteri asam laktat (BAL) dalam fermentasinya. Bakteri asam laktat di dalam kefir telah banyak dilaporkan memberi manfaat menyehatkan bagi saluran pencernaan manusia yang mengonsumsinya, dengan cara mengendalikan atau mengatur populasi bakteri patogen. Telaah ilmiah ini menjabarkan berbagai BAL dan perannya dalam proses pembuatan kefir, mekanisme yang dilakukan BAL dalam mengendalikan populasi patogen dalam saluran pencernaan, serta efek fungsional BAL terhadap produk kefir. Dalam telaah literature ini diperoleh informasi bahwa Lactobacillus kefiranofaciens, L. kefiri, L. casei, L. delbrueckii dan L. brevis merupakan kelompok BAL yang paling umum terlibat dalam pembuatan kefir. Spesies–spesies BAL tersebut berperan dalam mengendalikan populasi mikroba saluran pencernaan melalui berbagai mekanisme, seperti produksi asam laktat, etanol, diasetil, hidrogen peroksida, reuterin atau bakteriosin. Efek fungsional yang dapat dilakukan oleh BAL setelah berada di dalam saluran pencernaan antara lain mencegah terjadinya infeksi bakteri patogen, menurunkan kadar kolesterol darah, meningkatkan sistem imun, dan sebagai antioksidan. Hal ini mengindikasikan bahwa BAL yang diisolasi dari kefir berpeluang dikembangkan sebagai probiotik potensial dimasa yang akan datang.

Kata Kunci: BAL, kefir, sistem pencernaan manusia
MENENTUKAN HARGA OPSI DENGAN METODE MONTE CARLO BERSYARAT MENGGUNAKAN BARISAN KUASI ACAK FAURE
Authors: ASTUTI PUTU WIDYA , DHARMAWAN KOMANG , SARI KARTIKA
Published: September 2021

An option contract is a contract that gives the owner the right to sell or even to buy an asset at the predetermined price and period time. The conditional Monte Carlo is one of the several methods that is used to determine the option price which in the process uses random numbers with normal standard distribution. At the same time, the random number generator can be substituted by using a quasi-random sequence, as in Faure's quasi-random sequence. The aim of this study is to determine the contract price of the call option with the European type by applying the conditional Monte Carlo method. This method used the Faure quasi-random sequence and compared it with the method of Monte Carlo standard, Monte Carlo standard in using the quasi-random sequence of Faure, and conditional Monte Carlo. The results of this study showed that the call option calculated using the conditional Monte Carlo method using the quasi-random Faure sequence began to stabilize at the 5000th simulation for K = 32575 and K = 34725 and in the 10000th simulation for K = 33000 and K = 33950. Research also show that with the conditional Monte Carlo in using the quasi-random sequence of Faure is more stable. Therefore, it is obtained its real value faster than the Monte Carlo standard, Monte Carlo standard in using the quasi-random sequence of Faure, and conditional Monte Carlo. The MAPE value of conditional Monte Carlo in using the quasi-random sequences of Faure and the Monte Carlo standard is smaller than the Monte Carlo standard in using the quasi-random sequence of Faure, and conditional Monte Carlo. Therefore, it can be said to be more accurate when calculating the European type call option price at BBCA.JK stocks.
ANALISIS FAKTOR PERSEPSI AKADEMISI TERHADAP PENGGUNAAN BUSANA ADAT DI LINGKUNGAN SEKOLAH
Authors: HARINI LUH PUTU IDA , SARI KARTIKA , SUSILAWATI MADE
Published: September 2021

Traditional Balinese clothing is a typical Balinese clothing that is characterized by Balinese customs used as a form of cultural protection that reflects the nature of politeness, shade, peace, and pride for the wearer. The Governor of Bali in the Regulation of the Governor of Bali Number 79 of 2018, concerning the Day for the Use of Balinese Traditional Clothing states that one of the objectives of using Balinese traditional clothing is to maintain and maintain the preservation of Balinese Traditional Clothing in order to strengthen identity, character and character, to recognize the values the aesthetic, ethical, moral, and spiritual values ??contained in Balinese culture and encourage increased use of local Balinese fashion products and industries. The purpose of this study was to determine the factors that influence academic perceptions of the use of traditional clothing in the school environment. This research was conducted in high schools in Denpasar, using the factor analysis method. The sample in this study were 181 respondents. The sampling technique used was purposive sampling. The results showed that the factors that influenced students' perceptions of the use of traditional clothing in the school environment were comfort in traditional clothing, knowledge of the rules of traditional dress, knowledge of traditional clothing, ethics of Balinese traditional dress and tourists and Balinese traditional clothing. These five factors can explain the diversity of students 'perceptions of 58.742 percent, with the dominant factor affecting students' perceptions of the use of traditional clothing in the school environment is comfort in traditional dress.
El lugar del adulto mayor en una educación orientada a la trasformación social y desarrollo humano
Authors: Pineda Castro Gustavo Enrique , Mora Olaya Leidy Johanna , Londoño Vásquez David Alberto
Published: September 2021

Objetivo: Este artículo aborda el tema del desarrollo humano a partir de la educación sin limitaciones etarias, donde el adulto mayor puede seguir (re)construyéndose a través de su participación en procesos educativos formales. Metodología: Selección de literatura a partir de cinco descriptores previamente definidos, en español, inglés y portugués, a través de Google Académico, teniendo en cuenta los criterios de visibilización e impacto. Resultados: Para ello, se resalta la educación desde una perspectiva crítica, la cual permite concebirla como una de las vías para la transformación social, destacando la posibilidad de vencer obstáculos, sobreponerse a las dificultades y avanzar a nivel personal, familiar y académico, tomando como pretexto a los adultos mayores que integran los programas de educación flexible en Colombia. Conclusiones: La formación se convierte en una opción para afianzar el tejido social, donde la alfabetización juega un papel vital en la búsqueda de la equidad y el reconocimiento del adulto mayor y propende por el desarrollo de habilidades que pueden ser requeridas en el proceso de formación escolar andragógico.
Estrés académico en estudiantes universitarios
Authors: Restrepo Jorge Emiro , Sánchez Omar Amador , Castañeda Quirama Tatiana
Published: September 2021

Objetivo: analizar el estrés académico en estudiantes universitarios. Para este propósito se definieron tres objetivos específicos: 1) identificar cuáles situaciones o condiciones del ambiente académico resultan más estresantes, 2) caracterizar las reacciones fisiológicas, psicológicas y comportamentales, y 3) conocer las estrategias de afrontamiento más frecuentes.
Método: se desarrolló una investigación con enfoque cuantitativo, transversal y de nivel descriptivo con una muestra de 450 estudiantes de tres universidades de Medellín y el Valle de Aburrá (dos instituciones privadas y una pública) utilizando el Inventario SISCO del Estrés Académico.
Resultados: para la categoría Situaciones y condiciones estresantes, el ítem con más porcentaje en la clasificación alto fue el de Sobrecarga de tareas y trabajos escolares. Para la categoría Reacciones físicas, el ítem con más porcentaje en la clasificación alto fue el de Inquietud (este ítem presentó diferencias según la edad). Para la categoría Reacciones psicológicas, el ítem con más porcentaje en la clasificación alto fue el de Somnolencia o mayor necesidad de dormir. Para la categoría Reacciones comportamentales, el ítem con más porcentaje en la clasificación alto fue el de Aumento o reducción del consumo de alimentos(este ítem presentó diferencias según el semestre). Para la categoría Estrategias de afrontamiento, el ítem con más porcentaje en la clasificación alto fue el de Habilidad asertiva.
Discusión: este conjunto de reacciones no hará más que menguar y perjudicar la capacidad intelectual y el desempeño académico de los estudiantes y, en muchos casos, el estrés académico (en conjunción con otras problemáticas) podría derivar en fracaso y deserción. Incluso podrían entretejer una trampa muy riesgosa para la salud y el proyecto de vida de personas jóvenes, en su mayoría menores de 25 años.
Paclitaxel - Combined Curcumin - Loaded PLA-TPGS - Based Nanoparticles Induce Apoptosis and Inhibit the Growth of Breast Cancer Cells and Multicellular Tumor Spheroids
Authors: Tu Nguyen Dac , Anh Tran Phan , Thu Ha Phuong , Nam Nguyen Hoai , Phuc Nguyen Xuan , Nhung Hoang Thi My
Published: September 2021

Paclitaxel and curcumin have been reported as anti-cancer drugs. Here we presented a novel combination of paclitaxel and curcumin-loaded PLA-TPGS (PTX-Cur/PLA-TPGS) nanoparticles prepared by a modified solvent extraction/evaporation technique. These nanoparticles were well distributed and stable in water. This combination of paclitaxel and curcumin gave a higher efficiency of both drugs in cytotoxicity; induced apoptosis; and effect on cell cycles of KPL4 cell line in compare with the use of paclitaxel or curcumin alone or even a normal mixture of these two drugs. Furthermore, PTX-Cur/PLA-TPGS nanoparticles exhibited a powerful ability in preventing MCF7 spheroids growth. Interestingly, curcumin also functioned as both a drug and a label. Base on the autofluorescence of curcumin, the absorption of PTX-Cur/PLA-TPGS nanoparticles into MCF7 spheroids could be followed and calculated. These results suggested that the nanoparticle-drug combination may provide a promising multifunctional delivery system for anti-cancer drugs.
In Silico Analysis of Osa-miR164 Gene Family in Rice (Oryza Sativa)
Authors: Tien Vuong Quang , Duong Nguyen Huy , Nhan Dao Trong , Vu Phan Minh , Phuc Do Thi
Published: September 2021

MicroRNA (miRNA) is a small non-coding RNA molecule containing about 22- 24 nucleotides, which functions in post-transcriptional regulation of gene expression. Previous reports have shown that miRNA plays an important role on the resistance ability of plants to adverse conditions. Rice (Oryza sativa) is a major food crop. Climate change makes the situation of salinity and drought in Vietnam worse, significantly affects rice cultivation area, leading to the decrease of the quantity and the quality of rice grains. In this research, we focused on miR164 family in rice. By using bioinformatics approach, we analyzed sequences of all osa-miR164 belonging to rice miR164 family, evaluated the expression profile of osa-miR164 under different stress conditions, predicted cis-regulatory elements on osa-miR164 gene promoters, and simultaneously predicted miR164-targeted genes and their expressions. The results showed the high conserve in mature osa-miR164 sequences but not in the precursor sequences, different expression pattern of osa-miR164 gene members under stress conditions and various cis-regulatory elements present in osa-miR164 gene promoters which may explain for diverse expression pattern of osa-miR164 genes. Some potential target genes of osa-miR164 were identified and their expressions under different stress conditions were analyzed.
State legal mechanism for ensuring environmental and technogenic safety
Authors: Chuklova Elena Valerievna
Published: September 2021

In the light of the ongoing state administration reform, it is relevant to examine the state legal mechanism for ensuring environmental and technogenic security as the types of national security. The subject of this research is the definition of the concept and structure of such mechanism, which is an essential condition for ensuring the protection of favorable environment; observance of the interests of citizens and legal entities, society and the state; prevention of threats of natural and technogenic emergency situations; and minimization of the consequences of such situations. On the institutional level, the state legal mechanism for ensuring environmental safety represents the system of governing institutions assigned with the implementation of the key directions and mechanisms for ensuring environmental and technogenic safety; as well as private and legal entities, whose legal status includes the rights and responsibilities in the sphere of ensuring environmental and technogenic safety. On the technological level, the state legal mechanism is characterized by the types of legal activity. On the instrumental level, it represent a set of means and methods at the disposal of the entities. The scientific novelty of this research lies in examination of the essential aspects of the state legal mechanism for ensuring certain types of national security, as well as in formulation of the concept of the state legal mechanism applicable to ensuring environmental and technogenic safety, the absence of which impedes the assessment of the effectiveness of such mechanism in relation to protection of identity, society, and the state from environmental and technogenic hazards, threats and conflicts. The conclusion is made that a range of problems arises in the context of formation of the state legal mechanism for ensuring environmental safety: the existing model of state regulation of greenhouse gas emissions, which is based on voluntary inventory, obstructs the acquisition of information on the volume of greenhouse gas emissions by the administrative authorities; the created information systems in the sphere of environmental security are not an effective mechanism for achieving the goals of the Strategy of Environmental Security; there is certain inconsistency in environmental surveillance regulation.
Principais complicações pós-operatórias: revisão narrativa
Authors: Vilefort Laís Assunção , Sabino Izadora Marina de Oliveira , Muniz Letícia Boniares , Santana Mariana Briglia de , Santos Matheus de Oliveira , Júnior Ivano Bahia Antunes , Baião Plínio Aristeu Mól , Atavila Fernanda Paula , Ramos Sofia de Melo , Sampaio Maria Carolina Ferraz Cajado
Published: September 2021

Objetivo: Abordar por meio de uma revisão narrativa sobre as principais complicações cirúrgicas pós-operatórias. Revisão bibliográfica: A partir da realização de um procedimento cirúrgico para manejar uma determinada patologia, pode acontecer o surgimento de uma outra doença. Mesmo com a técnica correta, toda cirurgia possui um risco, por menor que seja, nenhum procedimento cirúrgico está isento de complicações. A ocorrência de complicações pós-cirúrgicas representa uma mudança importante na recuperação do paciente, aumentando as chances dessa recuperação, o tempo de permanência hospitalar, a diminuição da disposição de leitos, aumento dos custos e o aumento da morbimortalidade. Os sistemas orgânicos mais suscetíveis às intercorrências são o cardiovascular, o urinário, o respiratório, o digestório e o hepatobiliar. As complicações cirúrgicas podem ser classificadas quanto ao período em que se manifestam em imediatas (nas primeiras 24 horas), mediatas (até o 7º dia) ou tardias (após a alta hospitalar definitiva) e também em gerais, especiais ou específicas. Considerações finais: Todo paciente submetido a um procedimento cirúrgico está susceptível a uma complicação pós-operatória. Portanto, é necessário conhecer e identificar tais complicações para instituir o tratamento de forma precoce com objetivo de reduzir ao máximo à morbimortalidade relacionada ao procedimento.
Poesía
Authors: Silva-Santisteban Rocio , Llerena Julio , Otero Diego , Yrigoyen José Carlos , Pólack Bruno , Pera Mario , Cruz-Álvarez Luis Alonzo , Allemant-Salas Melissa , Quiñonez Salpietro Ana Carolina , García Blesa Guadalupe
Published: September 2021

No presenta resumen
Entre lo cálido y lo visceral
Authors: Diestra Rocio , Sal y Rosas-Segura André Alejandro
Published: September 2021

Desde la exposición en quioscos, impreso en papel periódico y realizado por un sinfín de colaboradores, hasta las páginas de descarga gratuita de los zines más underground de la web, el cómic nos ha acompañado y se ha acoplado a nuestro estilo de vida a lo largo del siglo xx. Tanto en presentaciones que han cubierto los espacios de entretenimiento publicitario como en la realización de trabajos cada vez más personales y creativos; encontramos así un género inmensurable que navega por igual en las corrientes pop de esta era o en los escondrijos más íntimos del trabajo de autor.
Exploración del impacto de las habilidades para la vida sobre conductas de riesgo en adolescentes
Authors: Santana-Campas Marco Antonio , Cortés Irma , Domínguez Silvia
Published: September 2021

Resumen
De virus e infecciones en el cine: 1920-1980
Authors: León Frías Isaac
Published: September 2021

A propósito de la pandemia por la que estamos pasando actualmente, se hace un repaso de los distintos registros cinematográficos que se han hecho durante varias décadas de las enfermedades y los virus.
Minimalismo, afectos y escapes en el cine de Hong Sang-soo
Authors: Núñez Alberca Alejandro
Published: September 2021

Un repaso por las películas más representativas del  prolífico director surcoreano, que nos acercan a su particular estilo audiovisual. Entre situaciones sencillas y entornos cotidianos, con una trama aparentemente monótona y diálogos improvisados, muchas veces bajo los efectos del alcohol, se examinan las relaciones humanas de personajes que parecen repetirse, pero que son, finalmente, una proyección de su autor.
Clinical and diagnostic aspects of deep infiltrative endometriosis (diagnosis, treatment, recurrence)
Authors: Muftaidinova Shakhnoza K. , Faizullin Leonid Z. , Chuprynin Vladimir D. , Ruseikin Nikolai S. , Smolnova Tatiana I. , Buralkina Natalia A.
Published: September 2021

Aim. To analyze the recurrence of endometriosis after surgical treatment of patients with deep endometriosis. Materials and methods. The case histories of 90 patients aged 19 to 45 years were retrospectively analyzed. The study group consisted of 70 endometriosis patients: 20 with peritoneal endometriosis and 50 with deep infiltrative endometriosis (DIЕ). The comparison group included 20 women without endometriosis. There was an in-depth study of anamnestic data in the cohort of patients under study. The results of preoperative laboratory tests, including serum levels of the CA-125 and CA 19-9 oncomarkers, were processed. Results. Analysis of the obtained data showed that about half of the DIE patients (54%) in the main group had a history of surgical interventions for endometriosis. The number of operations was significantly higher in patients compared to the peritoneal endometriosis group (68% vs 20%, respectively; р=0.0012). Two subgroups were formed from the group of women with DIE: patients who had no history of previous surgical treatment for endometriosis and those hospitalized for repeated surgical treatment of endometriosis (patients with recurrent endometriosis). Patients with recurrent endometriosis had a significantly higher incidence of heavy menstruation, pregnancy terminations (abortions), and a high proportion of gastrointestinal diseases. Analysis of the hormonal therapy received in patients with DIE showed that every second patient with relapses (18/53%) after surgical treatment and every third patient without a prior history of surgery (5/31%) received hormonal therapy. Examination of the preoperative serum levels of CA-125 and CA 19-9 serum markers in patients with DIE showed an increase in their serum levels and a correlation with the frequency of endometriosis recurrence and the size of DIE foci. Conclusion. Despite the conservative and surgical treatment of DIE patients, the recurrence rate is still high. At present, there is no satisfactory therapy for all endometriosis patients. Therefore, the development of therapy for the conservative treatment of the disease remains an urgent task.
POR QUE O TEMPO SÓ CORRE PARA FRENTE E NUNCA PARA TRÁS? UMA PROPOSTA UTILIZANDO TEXTOS DE DIVULGAÇÃO CIENTÍFICA NO ENSINO DE FÍSICA
Authors: Coelho André Luís Miranda de Barcellos
Published: September 2021

Após tomar contato com o problema da possibilidade de reversão temporal nas estruturas lógico-matemáticas das teorias físicas pela dra. Marina Cortês (Universidade de Edimburgo) no Perimeter Institute, retornei ao Brasil decidido a trabalhar este tema com meus estudantes. O foco da proposta deste trabalho é a discussão na escola básica de alguns limites das teorias físicas e, portanto, da física ela mesma como disciplina. Fazemos isso por meio do uso de textos de divulgação científica, inspirados na proposta de leitura em três momentos de Solé. Pretende-se tornar claro que as ciências naturais são também um empreendimento proeminentemente humano, passível de revisão e certamente menos absoluto do que se costuma crer. Em especial, abordar este tema que notavelmente é e foi negligenciado na história das ciências físicas. O que procuramos ao utilizar textos de divulgação científica foi justamente vislumbrar uma possibilidade coerente e realizável de efetivar este desejo.
Cheiloscopy: An Early Indicator of Class I & Class II Malocclusion
Authors: Das Dr. Varsha , .S. Pai Dr. Vinaya , Krishna Dr. Siri , Gaonkar Dr. Shivaprasad , Kalladka Dr. Gautham , Rajaram Dr. Shreyas
Published: September 2021

This study was done to determine & correlate the lip print patterns in Skeletal Class I & Class II malocclusions. A sample of 160 individuals (80 skeletal Class I & 80 skeletal Class II malocclusion) aged 12 years and above, were selected for the study. A dark coloured lipstick was applied onto the cleaned & dried lips with a single stroke. A lip impression was made on a transparent cellophane tape strip which was removed & stuck to a white bond paper. Lip print patterns were analysed based on the Tsuchihashi classification i.e. Type I, Type I’, Type II, Type III, Type IV & Type V. The field of observation was confined to 10mm on either side of the quadrant from the midline and the pattern was resolved by counting highest number of lines in this area. Statistical analyses indicated that the prevalence of Type I & Type II lip pattern was significantly higher in Skeletal Class I & Class II malocclusion subjects respectively. The results showed a significant correlation between lip prints and skeletal sagittal malocclusion. Cheiloscopy can act as an early indicator of skeletal malocclusions, but further research is required for the evaluation of lip prints in a larger sample with distinctinherited malocclusions.
Contraception continuation rates and reasons for discontinuation in Zahedan, Islamic Republic of Iran
Authors: Rakhshani F. , Mohammadi M.
Published: September 2021

Wevaluated contraception continuation rates and discontinuation reasons in Zahedan among 1741 women from 1998-2000. By Kaplan-Meier technique continuation rates were 92% for low dose combined hormonal oral contraceptives [OC], 86% for a levonorgestrel-releasing implant, 82% for intrauterine devices [IUD] and 53% for medroxyprogesterone acetate at the first year. After 3 years, continuation was 78% for levonorgestrel implant, 70% for OC, 60% for IUD and 44% for medroxyprogesterone acetate. The commonest reason for discontinuing OC and medroxyprogesterone acetate was changing method; for IUD and levonorgestrel-releasing implant, the commonest reason was side-effects. By Cox regression model, continuation rate and contraceptive type were significantly related to health centre
Effect of exclusive breastfeeding and complementary feeding on infant growth and morbidity
Authors: Khadivzadeh T. , Parsai S.
Published: September 2021

A cohort study was conducted in the Islamic Republic of Iran between January 1997 and February 1998 to compare the growth and morbidity of 100 infants who were exclusively breastfed for 6 months and 100 who received breast milk and complementary foods between 4-6 months. Infants’ feeding pattern, weight and height were assessed and recorded. There were no significant differences in infants’ weight and height gain between 4 and 6 months. The rate of diarrhoea between ages 4 and 6 months was significantly lower in exclusively breastfed infants than in complementary food-fed infants [11% versus 27%] and respiratory infections were also lower [23% versus 35%]. We conclude that exclusive breastfeeding is superior at least until an infant is 6 months of age
Socioeconomic predictors of unconstrained child growth in Muscat, Oman
Authors: Mohamed A. J. , Onyango A. W. , de Onis M. , Prakash N. , Mabry R. M. , Alasfoor D. H.
Published: September 2021

Weconducted a study to identify socioeconomic factors associated with unconstrained growth among preschoolers in Muscat, Oman. A sample of children born in 1995 and aged 28-43 months was drawn from the Child Health Registers of 2 health care centres. Sociodemographic data were collected by oral interview and maternal and child anthropometry measured. Regression analysis was used to identify socioeconomic indicators and cut-offs associated with unconstrained growth. Children from households with a monthly income > or = 800 Omani rials and mother’s education > or = 4 years attained height-for-age levels comparable to the current international growth reference. By screening using this criterion, we could obtain a suitable sample for the World Health Organization Multicentre Growth Reference Study in Muscat
Efficacy of sulfadoxine/pyrimethamine for uncomplicated Plasmodium falciparum malaria in a small sample of Sudanese children
Authors: Adam I. , Ibrahim M. H. , Aelbasit I. A. , El Bashir M. I.
Published: September 2021

A prospective clinical trial was carried out to determine in vivo efficacy of sulfadoxine/pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in children in New Halfa. Forty patients were enrolled; 31 completed the 28-day follow-up. Six [19.4%] patients showed recurrence of parasitaemia during follow-up, while the rest [80.6%] cleared the parasites and responded fully to treatment. All the failures were late treatment failures. Parasite genotyping showed that 1 [16.7%] of the 6 cases of late parasitaemia was due to reinfection while the rest [83.4%] were due to true recrudescence. During the follow-up period 22.6% of patients showed gametocytaemia. The high level of treatment failure as well as gametocytaemia necessitates the introduction of artesunate in this combination therapy
Solar battery frame made of pipes triangular cross-section
Authors: Volkov M. V. , Dvirny V. V.
Published: September 2021

The vast majority of spacecraft use solar panels as their primary energy source. The widespread using of solar cells is due to the simplicity of the design, reliability, environmental safety and minimal impact on the electronics and radio elements of the spacecraft. The development of new, larger spacecraft is driven by increasing demands on their functionality. These requirements lead to the need to provide more and more payload capacity of the spacecraft, the growth of its mass. There are solar batteries with different types of substrate: flexible, semi-rigid and rigid. Many years of experience in the development and application of solar panels have led to the fact that domestic spacecraft in most designs use solar panels with a semi-rigid substrate consisting of pipes, fittings and strings. This design of the substrate has characteristics at the level of world analogues. The increase in the mass of the payload can be compensated by a decrease in the mass of the power supply system. Thus, to improve the mass-dimensional characteristics, it is possible to optimize the design of the main load-bearing elements-pipes, which implies a more efficient use of the material (reducing the margin of safety with constant rigidity of the frame). The paper presents the results of the study of the possibility of modernizing the structure of the frames of planar solar cells, increasing their mass-dimensional characteristics. The studies were carried out by computational and experimental methods, and experimental samples of pipes were manufactured and released. As a result of the work, a frame made of triangular pipes and fittings was developed, and the mass and mechanical characteristics of the frame were determined.
ISSUES OF ACHIEVING SUSTAINABLE DEVELOPMENT IN THE POST-PANDEMIC PERIOD AND EXPANDING THE ROLE OF HUMAN CAPITAL IN IT
Authors:   Gulistan state university of the Republic of Uzbekistan, Zikriyaev Zakir Mamurovich , Abduvokhidov Akmal , Buribayev Erkinjon , Makhmudov Sherali
Published: September 2021

Today, the countries of the world are experiencing a pandemic crisis that has arisen in connection with the COVID-19 pandemic. The pandemic crisis is characterized by the fact that, unlike other crises, it is a three-way crisis. In particular, the pandemic crisis is also characterized by demand, supply and, at the same time, a liquidity crisis. It should be said that the pandemic crisis has shown the need to improve the quality of the human factor and the associated human capital in order to achieve sustainable development. Based on this, the article analyzes the issues of expanding the positions of human capital in achieving sustainable development.Keywords:pandemic, global economic crisis, sustainable development, human factor, human capital, global trends in the development of the world economy, innovative development, national innovation system
THEORETICAL AND METHODOLOGICAL FUNDAMENTALS OF PUBLIC-PRIVATE PARTNERSHIP
Authors:   Tadqiqot LLC International journals portal, Atadjanova Dinara
Published: September 2021

This article examines the theoretical foundations and content of public-private partnership. It also presents the research of scientists who have analyzed the content, scientific basis and practical nature of public-private partnership. As a result of the research, the author gave an author definition of the concept of public-private partnership.Keywords: public, business entity, public-private partnership, public sector, infrastructure, investment, innovation, private partner.
FUNCTIONS OF JOINT STOCK COMPANIES IN THE ECONOMY AND IMPROVEMENT OF THEIR FINANCING
Authors:   Tashkent Financial Institute of the Republic of Uzbekistan, Chinkulov Kakhramon
Published: September 2021

The article was substantiated features of the activities of joint stock companies (JSCs), the theoretical and economic foundations of financing JSCs through shares, was analyzed the current state of financing JSCs through shares in the Republic of Uzbekistan, was described the priority directions of financing JSCs through shares, also developed scientific and practical conclusions andproposals
STRUCTURE OF A MARKETING MODEL FOR ENTERING AN INNOVATIVE MARKET
Authors:   Tashkent state university of economics of the Republic of Uzbekistan, Ruzmetova Makhsuda , Ashurov Azizbek
Published: September 2021

The article is devoted to the structure of the marketing model for entering the innovation market. The entry of an innovative product to the market begins with the type of customer that the product attracts to it and varies from one type of customer to another throughout the life cycle. Innovative marketing is one of the criteria for a balanced value system in the process of creating product value.Keywords. Product innovation, innovation diffusion, clipping theory, selection of a single identified economic buyer, market segmentation, competition assessment