bluuebunny/crossref_metadata_2025 huggingface dataset:
Mycobacterial MMAR_2193 catalyzes O-methylation of diverse polyketide cores
Authors: Giri Gorkha Raj , Saxena Priti
Published: January 2022

O-methylation of small molecules is a common modification widely present in most organisms. Type III polyketides undergo O-methylation at hydroxyl end to play a wide spectrum of roles in bacteria, plants, algae, and fungi. Mycobacterium marinum harbours a distinctive genomic cluster with a type III pks gene and genes for several polyketide modifiers including a methyltransferase gene, mmar_2193. This study reports functional analyses of MMAR_2193 and reveals multi-methylating potential of the protein. Comparative sequence analyses revealed conservation of catalytically important motifs in MMAR_2193 protein. Homology-based structure-function and molecular docking studies suggested type III polyketide cores as possible substrates for MMAR_2193 catalysis. In vitro enzymatic characterization revealed the capability of MMAR_2193 protein to utilize diverse polyphenolic substrates to methylate several hydroxyl positions on a single substrate molecule. High-resolution mass spectrometric analyses identified multi-methylations of type III polyketides in cell-free reconstitution assays. Notably, our metabolomics analyses identified some of these methylated molecules in biofilms of wild type Mycobacterium marinum. This study characterizes a novel mycobacterial O-methyltransferase protein with multi-methylating enzymatic ability that could be exploited to generate a palette of structurally distinct bioactive molecules.
Detection of MDM2 amplification by shallow whole genome sequencing of cell-free DNA of patients with dedifferentiated liposarcoma
Authors: Przybyl Joanna , Spans Lien , Ganjoo Kristen , Bui Nam , Mohler David , Norton Jeffrey , Poultsides George , Debiec-Rychter Maria , van de Rijn Matt
Published: January 2022

High-level amplification of MDM2 and other genes in the 12q13–15 locus is a hallmark genetic feature of well-differentiated and dedifferentiated liposarcomas (WDLPS and DDLPS, respectively). Detection of this genomic aberration in plasma cell-free DNA may be a clinically useful assay for non-invasive distinction between these liposarcomas and other retroperitoneal tumors in differential diagnosis, and might be useful for the early detection of disease recurrence. In this study, we performed shallow whole genome sequencing of cell-free DNA extracted from 10 plasma samples from 3 patients with DDLPS and 1 patient with WDLPS. In addition, we studied 31 plasma samples from 11 patients with other types of soft tissue tumors. We detected MDM2 amplification in cell-free DNA of 2 of 3 patients with DDLPS. By applying a genome-wide approach to the analysis of cell-free DNA, we also detected amplification of other genes that are known to be recurrently affected in DDLPS. Based on the analysis of one patient with DDLPS with longitudinal plasma samples available, we show that tracking MDM2 amplification in cell-free DNA may be potentially useful for evaluation of response to treatment. The patient with WDLPS and patients with other soft tissue tumors in differential diagnosis were negative for the MDM2 amplification in cell-free DNA. In summary, we demonstrate the feasibility of detecting amplification of MDM2 and other DDLPS-associated genes in plasma cell-free DNA using technology that is already routinely applied for other clinical indications. Our results may have clinical implications for improved diagnosis and surveillance of patients with retroperitoneal tumors.
Variation of phenotypic and physiological traits of Robinia pseudoacacia L. from 20 provenances
Authors: Guo Qi , Sun Yuhan , Zhang Jiangtao , Li Yun
Published: January 2022

To select elite Robinia pseudoacacia L. germplasm resources for production, 13 phenotypes and three physiological indicators of 214 seedlings from 20 provenances were systematically evaluated and analyzed. The leaf phenotypic and physiological coefficients of variation among the genotypes ranged from 3.741% to 19.599% and from 8.260% to 42.363%, respectively. The Kentucky provenance had the largest coefficient of variation (18.541%). The average differentiation coefficients between and within provenances were 34.161% and 38.756%, respectively. These close percentages showed that R. pseudoacacia presented high genetic variation among and within provenances, which can be useful for assisted migration and breeding programs. Furthermore, based on the results of correlations, principal component analysis and cluster analysis, breeding improvements targeting R. pseudoacacia’s ornamental value, food value, and stress resistance of were performed. Forty and 30 excellent individuals, accounting for 18.692% and 14.019%, respectively, of the total resources. They were ultimately screened, after comprehensively taking into considering leaf phenotypic traits including compound leaf length, leaflet number and leaflet area and physiological characteristics including proline and soluble protein contents. These selected individuals could provide a base material for improved variety conservation and selection.
Clotting events among hospitalized patients infected with COVID-19 in a large multisite cohort in the United States
Authors: Nemetski Sondra Maureen , Ip Andrew , Josephs Joshua , Hellmann Mira
Published: January 2022

Introduction

COVID-19 infection has been hypothesized to precipitate venous and arterial clotting events more frequently than other illnesses.

Materials and methods

We demonstrate this increased risk of blood clots by comparing rates of venous and arterial clotting events in 4400 hospitalized COVID-19 patients in a large multisite clinical network in the United States examined from April through June of 2020, to patients hospitalized for non-COVID illness and influenza during the same time period and in 2019.

Results

We demonstrate that COVID-19 increases the risk of venous thrombosis by two-fold compared to the general inpatient population and compared to people with influenza infection. Arterial and venous thrombosis were both common occurrences among patients with COVID-19 infection. Risk factors for thrombosis included male gender, older age, and diabetes. Patients with venous or arterial thrombosis had high rates of admission to the ICU, re-admission to the hospital, and death.

Conclusion

Given the ongoing scientific discussion about the impact of clotting on COVID-19 disease progression, these results highlight the need to further elucidate the role of anticoagulation in COVID-19 patients, particularly outside the intensive care unit setting. Additionally, concerns regarding clotting and COVID-19 vaccines highlight the importance of addressing the alarmingly high rate of clotting events during actual COVID-19 infection when weighing the risks and benefits of vaccination.
RplI interacts with 5’ UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa
Authors: Wang Dan , Zhang Xinxin , Yin Liwen , Liu Qi , Yu Zhaoli , Xu Congjuan , Ma Zhenzhen , Xia Yushan , Shi Jing , Gong Yuehua , Bai Fang , Cheng Zhihui , Wu Weihui , Lin Jinzhong , Jin Yongxin
Published: January 2022

Pseudomonas aeruginosa is an important opportunistic pathogen capable of causing variety of infections in humans. The type III secretion system (T3SS) is a critical virulence determinant of P. aeruginosa in the host infections. Expression of the T3SS is regulated by ExsA, a master regulator that activates the expression of all known T3SS genes. Expression of the exsA gene is controlled at both transcriptional and posttranscriptional levels. Here, we screened a P. aeruginosa transposon (Tn5) insertional mutant library and found rplI, a gene coding for the ribosomal large subunit protein L9, to be a repressor for the T3SS gene expression. Combining real-time quantitative PCR (qPCR), western blotting and lacZ fusion assays, we show that RplI controls the expression of exsA at the posttranscriptional level. Further genetic experiments demonstrated that RplI mediated control of the exsA translation involves 5’ untranslated region (5’ UTR). A ribosome immunoprecipitation assay and qPCR revealed higher amounts of a 24 nt fragment from exsA mRNA being associated with ribosomes in the ΔrplI mutant. An interaction between RplI and exsA mRNA harboring its 24 nt, but not 12 nt, 5’ UTR was confirmed by RNA Gel Mobility Shift and Microscale Thermophoresis assays. Overall, this study identifies the ribosomal large subunit protein L9 as a novel T3SS repressor that inhibits ExsA translation in P. aeruginosa.
Lisboa, 1975. A correspondência da Embaixada alemã sobre o refúgio concedido a quatro oficiais golpistas
Authors: Louçã António
Published: January 2022

Os oficiais golpistas derrotados em 11 de março de 1975 foram em parte afastados dos seus cargos, em parte detidos ou, em menor número, refugiaram-se na vizinha Espanha. Quatro oficiais da GNR, incluindo um general, pediram asilo na Embaixada da República Federal da Alemanha. O pedido era embaraçoso para a Embaixada, que então envidava esforços consideráveis para melhorar as suas relações com a esquerda civil e com o MFA. Não lhes concedeu asilo, mas acolheu-os temporariamente na Embaixada. Comunicou o facto ao seu Ministério, em Bona, e à Presidência da República portuguesa. De Bona recebeu instruções para não entregar os quatro hóspedes, da Presidência portuguesa a exigência de entregá-los imediatamente. Obteve o compromisso de os fazer pernoitar na Embaixada, mas na manhã seguinte, com a Embaixada cercada por manifestantes, era impossível ganhar mais tempo. O embaixador Fritz Caspari ignorou as instruções que continuavam a chegar-lhe de Bona e convenceu os quatro a entregarem-se, mediante o compromisso de que ele próprio se fazia fiador, de serem julgados em tribunais ordinários e de as suas famílias poderem partir para a Alemanha. Nos meses seguintes, os quatro permaneceram detidos, sendo o último libertado um ano depois do golpe. Caspari avaliara acertadamente a situação e, com as decisões tomadas no terreno, preservara a possibilidade de uma diplomacia ativa da RFA no processo político português.
Vestígios da ocupação do Ferro Antigo de Coimbra (Portugal) e o mito fundacional do local
Authors: Almeida Sara , Vilaça Raquel , Silva Ana Maria , Detry Cleia , Filipe Sónia
Published: January 2022

Apresenta-se o primeiro e para já único contexto conhecido da I Idade do Ferro de Coimbra. Reporta-se a uma intervenção arqueológica de salvaguarda realizada no Largo de D. Dinis, em 2008. Neste local identificou-se um depósito estratigráfico pouco extenso, encerrando espólio cerâmico e restos ósseos humanos e faunísticos. Embora modesto e desgarrado, o conjunto resulta desconcertante pelas questões que levanta quanto à natureza do achado – afigurando-se como um possível depósito fundacional. Para mais, a sua relevância objectiva-se na confirmação da ocupação sidérica antiga da cidade, reunindo-se assim Coimbra às destacadas referências do período orientalizante do Baixo Mondego.
Using the Fisher Vector Approach for Cold Identification
Authors: Egas-López José Vicente , Gosztolya Gábor
Published: January 2022

In this paper, we present a computational paralinguistic method for assessing whether a person has an upper respiratory tract infection (i.e. cold) using their speech. Having a system that can accurately assess a cold can be helpful for predicting its propagation. For this purpose, we utilize Mel-frequency Cepstral Coefficients (MFCC) as audio-signal representations, extracted from the utterances, which allowed us to fit a generative Gaussian Mixture Model (GMM) that serves to produce an encoding based on the Fisher Vector (FV) approach. Here, we use the URTIC dataset provided by the organizers of the ComParE Challenge 2017 of the Interspeech Conference. The classification is done by a linear kernel Support Vector Machines (SVM); owing to the high imbalance of classes on the training dataset, we opt for undersampling the majority class, that is, to reduce the number of samples to those of the minority class. We find that applying Power Normalization (PN) and Principal Component Analysis (PCA) on the Fisher vector features is an effective strategy for the classification performance. We get better performance than that of the Bag-of-Audio-Words approach reported in the paper of the challenge.
Energy-Efficient Routing in Wireless Sensor Networks
Authors: Pásztor Dániel , Ekler Péter , Levendovszky János
Published: January 2022

Efficient data collection is the core concept of implementing Industry4.0 on IoT platforms. This requires energy aware communication protocols for Wireless Sensor Networks (WSNs) where different functions, like sensing and processing on the IoT nodes must be supported by local battery power. Thus, energy aware network protocols, such as routing, became one of fundamental challenges in IoT data collection schemes.In our research, we have developed novel routing algorithms which guarantee minimum energy consumption data transfer which is achieved subject to pre-defined reliability constraints. We assume that data is transmitted in the form of packets and the routing algorithm identifies the paths over which the packets can reach the Base Station (BS) with minimum transmission energy, while the probability of successful packet transmission still exceeds a pre-defined reliability parameter. In this way, the longevity and the information throughput of the network is maximized and the low energy transmissions will considerably extend the lifetime of the IoT nodes. In this paper we propose a solution that maximizes the lifetime of the nodes.
Toolset for Supporting the Research of Lattice Based Number Expansions
Authors: Hudoba Péter , Kovács Attila
Published: January 2022

The world of generalized number systems contains many challenging areas. Computer experiments often support the theoretical research. In this paper we introduce a toolset that helps to analyze some properties of lattice based number expansions. The toolset is able to (1) analyze the expansions, (2) decide the number system property, (3) classify and visualize the periodic points. The toolset is implemented in Python, published alongside with a database that stores plenty of special expansions, and is able to store the custom properties like signature, operator eigenvalues, etc. Researchers can connect to the server and request/upload data, or perform experiments on them. We present an introductory usage of the toolset and detail some results that has been observed by the toolset. The toolset can be downloaded from http://numsys.info domain.
Cross-disciplinary, collaborative and student-led: developing a change process for diversifying reading lists
Authors: Adewumi Barbara , Bailey Laura R. , Mires-Richards Emma , Quinlan Kathleen M. , Agyeman Evangeline , Alabi Aisha , Jeyasingh Miriam , Konadu-Mensah Collins , Lavinière Wayne , Mighton Patrice , Shortridge Tore , Thomas Dave S.P. , Wassamba-Wabelua Nain
Published: January 2022

Increasingly across many UK higher education institutions staff and students are questioning and challenging systemic inequalities that affect racially minoritised groups in their learning and sense of belonging within the curriculum. Students are calling for inclusion of diverse sources of knowledge and perspectives, especially from scholars of colour and from the Global South, to enrich what is currently perceived to be a Eurocentric canon. One way to promote more culturally aligned pedagogy is through diversifying reading lists. This article presents findings from two pilot studies that explored the reading lists in one department in social sciences and one in the humanities at the University of Kent, UK. Applying critical race theory as a guiding framework, the first part of the article examines the ways in which a diverse curriculum must include the voices of the marginalised. It then describes the methods: a desk-based review of the reading lists, interviews with academics to inform the work, disseminate the findings, instigate further action and identify future needs, and student focus groups. Crucially, the project resulted from the collaboration between students and staff, and across departments and disciplines. We found that reading lists in both departments overwhelmingly comprised items by White male authors. Students and staff both reflected on the importance of not only curriculum diversification but also barriers to diversification and decolonisation. The article discusses the impact of this project, which has led to a Diversity Mark process, and the Diversity Mark Toolkit, which can be used in any discipline when putting together reading lists to create a more culturally competent curriculum. It concludes by considering other systemic changes needed, with particular attention to changes needed in library services and collections.
Cell-based Therapy Approach for Drug-resistant Epilepsy
Authors: Mahajan Pradeep V. , Subramanian Swetha , Parab Siddhesh C. , Mahajan Sanskruti
Published: January 2022

Drug-resistant epilepsy (DRE) is a global public health problem. This category includes patients who continue to experience seizures despite long-term anti-epileptic medications. DRE can lead to severe disability and morbidity in older children and adults and is associated with increased risk of mortality than the general population. This report describes the case of a 15-year-old male patient with DRE successfully managed with autologous cell-based and hyperbaric oxygen therapy. The patient underwent two sessions of cell-based therapy consisting of cells derived from the bone marrow, adipose tissue, and peripheral blood followed by neuro-physiotherapy and oxygen therapy. Post-treatment, the patient experienced decrease in the frequency of seizures and reduction in the dosage of anti-epileptic medications. Electroencephalogram taken one year after the therapy revealed improvement in seizure activity. The outcomes in this case may be considered a preliminary finding in formulating more robust treatment strategies using cell-based therapy for DRE.
Therapeutic Challenge in a Case of Recent Onset Refractory Cluster Seizures
Authors: Sureshbabu Sachin , Padmanabhan Muralikrishnan Veleri , Alappat Jacob , Mohanlal Smilu , Janardhanan Sujith , Karunanidhi Sellam , Kannan Lakshminarayan , Nayak Dinesh , Shekhar Biju
Published: January 2022

A dilemma exists in context to the timing of surgery in a case presenting with explosive onset seizures secondary to a focal cortical dysplasia (FCD). This case report highlights the challenges faced in the management of a 4-year-old child with recent onset cluster seizures refractory to anti-epileptic drugs. A 4-year-old girl presented with an acute onset of cluster seizures (up to 32 in a day), semiologically characterized by tonic upper limb extension and laughter lasting for few seconds with no response to multiple anti-epileptic drugs. The clinical, electrographic, neuroimaging and interictal positron emission tomography data were concordant and consistent with a left middle frontal gyrus dysplasia which was successfully resected under electrocorticographic guidance. Patient is seizure free at 2 months of follow up. (Engel Class 1). Surgical resection is feasible and potentially more effective in the early phase of clinical presentation of FCD.
The relationship between postpartum social support and attitudes towards breastfeeding: A cultural perspective
Authors: Karataş Okyay Esra , Sunay Zeliha , Cengizhan Sıdıka Özlem , Kamalak Hülya , Uçar Tuba
Published: January 2022

Aim: This study intends to provide an analysis of the relationship between postpartum social support and women’s breastfeeding attitudes from different cultural perspectives. Method: This study was conducted between April-September 2019.The study population comprised of 430 women with 4-24 week old babies who visited health centers in the provinces of Adıyaman (Region 1), Kahramanmaraş (Region 2) and Malatya (Region 3). Findings: The mean scores of women from the BAES were 105.54 ± 13.16 in Region 1, 103.30 ± 15.77 in Region 2, and 99.46 ± 13.47 in Region 3 (P<0.05).The mean scores of women from the “Importance of the Need” subscale on the PSQ were 157.38±45.57 in Region 1, 140.73±55.18 in Region 2, and 144.89±48.144 in Region 3 (P<0.05).The mean scores of women from the “Support Received” subscale on the PSQ were 112.39±51.58 in Region 1; 116.87±52.69 in Region 2, and 108.89±50.79 in Region 3 (P>0.05).In Region 2, a significant and positive correlation was found between the subscales “Importance of the Need” and the “Perceived Support” on the BAES and the PSQ (r=0.259, r=0.255, P<0.05, respectively). Conclusion: A comparison of the relationship between postpartum social support and attitudes towards breastfeeding revealed major differences between the Regions.
Why, How, and When to Integrate Narrative Identity Within Dimensional Approaches to Personality Disorders
Authors: Lind Majse , Sharp Carla , Dunlop William L.
Published: January 2022

Researchers and clinicians are beginning to adopt dimensional approaches in the study and treatment of personality disorders (PD). Although dimensional approaches in the DSM-5 and ICD-11 hold considerable benefit, they need to better incorporate an appreciation of individuals' life stories, or narrative identities. Doing so will be necessary to flesh out the emphasis that both frameworks place on the role of identity in personality pathology. In this article, the authors review why, how, and when narrative identity theory and research can be integrated within dimensional approaches to PD. The authors describe established ways to assess narrative identity, review extant research on this construct in relation to PD, and signal areas crucial for future research. Stories lie at the heart of what it means to be human. The authors conclude that a greater consideration of the ways in which the self is storied can help further understanding and treatment of PD.
Stres w pracy nauczyciela języków obcych
Authors:   Akademia Techniczno-Humanistyczna w Bielsku-Białej. Wydział Społeczno-Humanistyczny. Instytut Neofilologii, Polok Krzysztof
Published: January 2022

The aim of the article is to analyze a number of issues related to the topic of stress in the work of a language teacher, and to focus on those moments that are particularly strongly influenced by stress, in many cases causing forms of learners’ functioning to be affected by the teacher’s stress. The techniques used in the article are based on the meta-analysis format and the proposal of a stricter implementation of divergent work procedures during the language lesson. The proposals presented in the conclusion should result not only in a deeper involvement of students in the contents of the lesson, but also a generally lower level of stress load affecting the actions of both the language teacher and his/her students.
Mutualistic interaction of aphids and ants in pepper, Capsicum annuum and Capsicum frutenscens (Solanaceae)
Authors: Duque-Gamboa Diana Nataly , Arenas Clavijo Anderson , Posso-Terranova Andres , Toro-Perea Nelson
Published: January 2022

Introduction: Adequate biological identification is fundamental for establishing integrated pest management programs and identifying the trophic and mutualist relationships that can affect pest population dynamics. Aphids are the main pest of pepper Capsicum spp. (Solanaceae) crops in Southwestern Colombia, due to their role as vectors of viruses. However, the identification of aphid species is complex, limiting the investigations performed to address their interactions with other organisms. Ants and aphids present a facultative mutualistic relationship, that promotes the growth of hemipteran colonies, for this reason, the study of the ecological mutualistic association between aphids and ants is important. Objective: The main objective was to discriminate the aphid species present in commercial crops of Capsicum spp., and to identify the ant community that attends the aphid colonies and its effects on the size of the aphid colonies. Methods: Aphid species, and their ant mutualist, were collected from Capsicum annuum and Capsicum frutescens, in the Cauca valley, Southwestern Colombia. We use the DNA barcoding approach to identify aphid species, and the ants were identified by morphology‐based taxonomy. To evaluate the effect of ant care on the size and structure of aphid colonies, generalized linear models were calculated using as the response variables the total number of aphids for each colony and the proportion of nymphs. Results: The aphid species that attack pepper crops, are: Aphis gossypii and Myzus persicae (Hemiptera: Aphididae), with A. gossypii being the species that interacts with ants (19 ant species). A. gossypii colonies attended by ants had larger sizes and more nymphs per colony, than those not attended. Conclusions: Although the aphid-ant interaction is not species-specific, it is necessary to consider its role in the propagation of viral diseases in peppers and to determine how this interaction may affect regional biological control strategies.
Do blood parasites increase immature erythrocytes and mitosis in amphibians?
Authors: González Leydy P. , Vargas-León Carolina M. , Fuentes-Rodríguez Gustavo Andrés , Calderón-Espinosa Martha L. , Matta Nubia E.
Published: January 2022

Introduction: In amphibians, blood may act as a hematopoietic tissue. However, the knowledge concerning hematological features is scarce, there is not much information that allows an analysis about the possible explanations of this physiological feature. Objective: This study aimed to evaluate the relationship between immature red blood cells (RBCs) mitosis and the presence of blood parasites in amphibians. Methods: We sampled 116 amphibians (31 species) in six Colombian localities. Blood was taken by cardiac puncture or maxillary vein puncture. Smears were prepared, fixed, and Giemsa stained for microscopical analysis. The variables analyzed were the percentage of immature RBCs, mitotic cells in peripheral blood, and blood parasite infection. Data were analyzed using Wilcoxon's rank test and exact Fisher statistical tests. Results: Sixty-two individuals showed mitosis in peripheral blood, and these mitotic RBCs shared morphological features with immature RBCs. Overall, parasite prevalence was 30.1 %, distributed as follows: Trypanosoma (24.1 %), Hepatozoon-like (6 %), Dactylosoma (4.3 %), Karyolysus-like (0.9 %), and Filarioidea (2.6 %). A positive association between the percentage of immature RBCs and the presence of mitotic RBCs was found, and also between the blood parasite infection and the percentage of immature RBCs. Conclusions: In this study, we found that the presence of blood parasites, immature RBCs, and RBCs mitosis are frequent events in amphibians' peripheral blood, and our analysis suggests an association between those features. Thus, the release of immature RBCs and the mitosis of those cells in peripheral blood may be a physiological response to blood parasite infection. Further studies characterizing hematology in amphibians and wildlife, in general, are desirable.
Lichen community structure and richness in three mid-elevation secondary forests in Costa Rica
Authors: Cordero S. Roberto A. , Garrido Ana , Pérez-Molina Junior Pastor , Ramírez-Alán Óscar , Chávez José Luis
Published: January 2022

Introduction: Lichen diversity, community structure, composition and species abundance have been used as indicators of the integrity and ecological continuity of tropical forest ecosystems. Objectives: To assess corticolous lichen species composition, diversity, and ecological importance of three forested stands differing in time of abandonment as indicators of how passive restoration influences the lichen community assemblage. Methods: We surveyed individual lichens on tree stems of a reference old secondary forest and a young secondary forest (50 and 14-year-old natural regeneration after pasture abandonment, respectively), and in a 35-year-old exotic cypress tree plantation, in the oriental Central Valley, in Orosí, Costa Rica. Standard diversity, similarity indexes, and the importance value index were calculated. An NMDS analysis was performed on the community structure parameters and in a presence-absence matrix. Results: We found 64 lichen species in 25 families with 42, 21, and 23 species, and 20, 10, and 15 families, in the young and old secondary forests, and the cypress plantation, respectively. Cryptothecia sp. possessed the highest importance across sites. More than 87 % of the species are rare. The combined IVI of the top three families were: 36, 48.5, and 74.8 % in the young and old forests and the Cypress plantation sites, respectively. Overall, Arthoniaceae is in the top three families. The young forest had the highest species richness, but the old forest presented the best evenness. Similarity and diversity indexes suggest a particularly low resemblance in the lichen communities but a smooth gradient differentiation between the three forests, which was confirmed by the NMDS test. The homogeneity test identified great differences in ecological importance and composition. Conclusions: This region contains a distinctive assemblage of species resulting in a strong community differentiation by site, reflecting the influence of ecophysiological and microclimatic factors that define lichen establishment and survival and suggesting a great regional beta diversity, within a fragmented landscape. Greater connectivity and passive restoration strategies resulted in greater diversity and a more heterogeneous community structure on both forests than the corticolous community of the abandoned plantation. Protection of forest fragments will maximize the integrity of future forests.
In Stein gemeisselte Geschichte(n): Nikolaus Rhodokanakis (1876‒1945), Pionier der Altsüdarabistik
Authors: Sturm Gertraud , Maraqten Mohammed
Published: January 2022

Die detaillierte Biographie von Nikolaus Rhodokanakis deckt bisher Unbekanntes auf. Seine wissenschaftliche Arbeit und sein Werdegang werden beleuchtet und es wird versucht, den Menschen aufzuspüren, der hinter dem Gelehrten und Lehrer steckt. Die Biographie zeigt seine großen Verdienste um die historischen und kulturgeschichtlichen Wissenschaften und besonders seine Rolle als Gründungsfigur der Altsüdarabistik. Mit der Entzifferung der altsüdarabischen Inschriften und der Methodik, die er dafür entwickelt hat sowie der Entschlüsselung von etlichen ihrer Haupttexte, schuf er die Grundlage für deren weitere Erforschung. Er war damit maßgeblich an der Etablierung der Sabäistik über die Universität Graz hinaus auch im internationalen akademischen Rahmen beteiligt. Er begeisterte zahlreiche Schülerinnen und Schüler für dieses hochkomplexe Forschungsfeld. Unter seiner Anleitung eigneten sie sich beachtliches Wissen an, erweiterten später seine Forschungen und brachten sie zu neuer Blüte. Damit bereitete Rhodokanakis, gemeinsam mit Maria Höfner und Karl Mlaker, die altsabäistische Erschließung eines Großteils jener Inschriften auf, die Eduard Glaser aus dem Jemen nach Wien gebracht hat. Dass die im österreichischen Raum beheimatete Forschungstradition zu Altsüdarabien in der ersten Hälfte des 20. Jahrhunderts als hochspezialissierte semitistisch-philologische Expertise in Kombination mit interdisziplinären Fachkompetenzen weiterentwickelt wurde und größtes internationales Ansehen erwarb, ist in erster Linie diesem kultivierten Spitzenforscher zu verdanken.
Possibilities for integrated control of the cotton bollworm (Helicoverpa armigera Hübner, 1808) in the growing tomato in greenhouses
Authors: Mineva R. , Yankova V. , Valchev N.
Published: January 2022

Abstract. In recent years, there has been a significant increase in the number of cotton bollworm (Helicoverpa armigera Hb., 1808) due to changing climatic conditions, the covert life cycle of caterpillars and the formation of resistance in the populations to some of the commonly used insecticides. Experiments with tomato variety Pink Rock F1 grown in greenhouses to determine the biological activity of some products for plant protection against cotton bollworm were conducted at the “Maritsa” Vegetable Crops Research Institute – Plovdiv. The bioproducts Rapax, Dipel 2X, Helicovex, Neem Azal T/S and Sineis 480 SC have good effectiveness >77% towards cotton bollworm in the interval 7-14 days after treatment. The tested insecticides Lanate 25 WP, Coragen 20 SC 200 ml/ha, Exalt 25 SC, Voliam Targo 063 SC, Ampligo 150 ZC and Affirm 095 SG show very good biological activity (E>84%) 7-14 days after treatment.
A malignus daganatok és az ischaemiás stroke kapcsolata.
Authors: Hajnóczky Nóra , Bereczki Dániel
Published: January 2022

Összefoglaló. A malignus daganat és a stroke egy-egy betegnél
gyakran kombinálódik, sokszor egyidejűleg diagnosztizálják, vagy rövid idő telik
el a két kórkép felismerése között. Az együttes megjelenés hátterében elsősorban
a hasonló tradicionális rizikófaktorok állhatnak: az idősebb életkor, a magas
vérnyomás, a hyperlipidaemia, a cukorbetegség, az elhízás és a dohányzás. Az
átfedő kockázati tényezőkön túl a daganat által okozott hiperkoaguláció artériás
és vénás thrombosis kialakulásához vezethet. A hiperkoaguláció hátterének
kutatása főként a thrombocyták és a szöveti faktor aktiválására és a heparanáz
fokozott expressziójára fókuszált, és felvetődött a neutrophil extracelluláris
csapdák szerepe is. A daganat által okozott hiperkoagulációhoz társuló cryptogen
(tradicionális rizikófaktor nélküli) stroke-ban sokszor található magasabb
D-dimer-szint, és a CT/MRI-képeken gyakrabban látszanak multifokális, több ér
ellátási területében megjelenő ischaemiás laesiók, melyek ritkábban fordulnak
elő a tradicionális rizikófaktorokkal magyarázható stroke-okban. Az előzőkön
kívül a daganatok kezelésére alkalmazott kemoterápia és sugárterápia is emeli a
stroke kockázatát. A malignus daganatokhoz társuló stroke-ok megelőzése
érdekében további vizsgálatok szükségesek a daganat által okozott
hiperkoaguláció és vascularis változások pontosabb megértéséhez. Orv Hetil.
2022; 163(1): 3–11.

Summary. Cancer and stroke have long been studied individually, but
their detrimental forces together have also been a strong point of focus. The
occurrence of both cancer and stroke in a patient is often a reflection of their
similar risk factors (hypertension, hyperlipidemia, diabetes, obesity, and
smoking), however, a subgroup of the cancer stroke population is believed to
occur due to cancer-associated hypercoagulability. A deeper look into the
cancer-associated hypercoagulable environment has indicated that thrombosis may
be explained by cancer’s role in several factors, including activation of
platelets and tissue factor, elevated expression of heparanase and influence on
neutrophilic extracellular traps. When a cryptogenic stroke (stroke lacking the
aforementioned risk factors) occurs due to the cancer-induced hypercoagulation
state, patient serum D-dimer levels have been found elevated, and CT/MRI images
of the brain have shown multivascular infarctions compared to stroke patients
with traditional risk factors. Additionally, cancer treatment – chemotherapy and
radiation – have also been found to increase the occurrence of cerebral vascular
thrombosis. Further investigations are required to better understand
cancer-associated vascular pathophysiologic changes and how to discern their
unique strokes compared to strokes from other etiologies. With these insights,
the prevalence of strokes in the cancer population could be decreased. Orv
Hetil. 2022; 163(1): 3–11.
Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine
Authors: Sun Yudong , Locasale Jason W.
Published: January 2022

S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing. The importance of SAM is highlighted by its widespread usage as an over-the-counter nutrient supplement and as an experimental reagent in molecular biology. The bioavailability and cellular transport properties of SAM, however, are often overlooked under these contexts, putting limits on SAM’s therapeutic potential and complicating the interpretation of experimental results. In this article, we examined the chemical stability and cellular permeability of SAM, proposed a schematic for indirect SAM transport across the mammalian plasma membrane, and lastly discussed the implications arising from such transport schematic.
A ROBUST ITERATIVE APPROACH FOR SOLVING NONLINEAR VOLTERRA DELAY INTEGRO–DIFFERENTIAL EQUATIONS
Authors: Ofem Austine Efut , Udofia Unwana Effiong , Igbokwe Donatus Ikechi
Published: January 2022

This paper presents a new iterative algorithm for approximating the fixed points of multivalued generalized \(\alpha\)–nonexpansive mappings. We study the stability result of our new iterative algorithm for a larger concept of stability known as weak \(w^2\)–stability. Weak and strong convergence results of the proposed iterative algorithm are also established. Furthermore, we show numerically that our new iterative algorithm outperforms several known iterative algorithms for multivalued generalized \(\alpha\)–nonexpansive mappings. Again, as an application, we use our proposed iterative algorithm to find the solution of nonlinear Volterra delay integro-differential equations. Finally, we provide an illustrative example to validate the mild conditions used in the result of the application part of this study. Our results improve, generalize and unify several results in the existing literature.
A Comparative Analysis on Stock Price Prediction Model using DEEP LEARNING Technology
Authors: Jaiswal Rupashi , Mahato Kunal , Kapoor Pankaj , Pal Sudipta Basu
Published: January 2022

In today's world, Artificial Intelligence and Deep Learning are getting popular regularly. The various applications areas of artificial intelligence are related to human activity. One of the general application areas of neural networks and artificial intelligence is prediction analysis.
In this paper, the authors also have performed one comparative study based on artificial intelligence. Authors have performed stock market predictions using different models. In reality, stock markets are entirely volatile, so there is very much a requirement of good prediction analysis for
judging the stocks prices and their ups and downs with time. The stock prices can easily be predicted using machine learning algorithms on data available in financial news, as this data can also change investors' interests. However, traditional prediction methods have become obsolete and do
not provide accurate predictions over non-stationary time series data. This paper proposes a stock price prediction method that gives accurate results with the advancements in deep learning technologies.
COVID-19 associated multisystem inflammatory syndrome in children mimicking acute appendicitis - how to differentiate and conduct pediatric patients during the pandemic? - Proposal of a management flowchart
Authors: FALQUETO LORAINE ENTRINGER , VISSOCI CAROLINA MARTINS , FERREIRA ISABELLA CRISTINA BONETTO , ANTUNES AMANDA GINANI , AMADO FERNANDO ANTÔNIO BERSANI , AVILLA SYLVIO ANDRADE GILBERTO , SCHULZ CLAUDIO , MOTTA FABIO ARAUJO , SILVA ELISANGELA DE MATTOS E
Published: January 2022

ABSTRACT Introduction: the new coronavirus pandemic has been a reality throughout 2020, and it has brought great challenges. The virus predominantly manifests in the pediatric population with mild symptoms. However, an increase in the incidence of Multisystemic Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 has been described in the literature. MIS-C manifests mainly with fever and gastrointestinal symptoms and may mimic acute abdomen due to acute appendicitis. The objective of this study is to propose a care flowchart for suspected cases of acute appendicitis in the initial phase in pandemic times, considering the possibility of MIS-C. This situation was brought up by a patient treated in a pediatric hospital in Brazil. Discussion: It was possible to identify common signs and symptoms in the reported patient and those published cases that may serve as alerts for early identification of MIS-C cases. Based on the literature review and on the similarities between the syndrome and the inflammatory acute abdomen in children, we elaborated an initial approach for these cases to facilitate the identification, early diagnosis, and management. The flowchart considers details of the clinical history, physical examination, and complementary exams prior to the indication of appendectomy in patients with initial phase symptoms. Conclusion: MIS-C, although rare and of poorly known pathophysiology, is most often severe and has a high mortality risk. The use of the proposed flowchart can help in the diagnosis and early treatment of MIS-C.
A ação e o pensamento de Fernão Bracher, um conservador com espírito público
Authors: VILLAVERDE JOÃO , REGO JOSÉ MARCIO
Published: January 2022

RESUMO Este artigo reflete a trajetória de Fernão Bracher à luz dos avanços institucionais na administração pública brasileira a partir da redemocratização de 1985. Descendente de família tradicional em São Paulo, Bracher vai canalizar seu espírito público e seu nacionalismo econômico em três oportunidades, notadamente a partir da superação do regime militar, quando preside o Banco Central do Brasil e depois se torna, a convite do amigo e ministro Luiz Carlos Bresser-Pereira, o negociador brasileiro da dívida externa. Menos teórico que Bresser, mas tão pragmático quanto ele, Bracher compartilhava a imensa curiosidade intelectual do amigo, tendo auxiliado na troca de reflexões entre os diferentes economistas envolvidos com a teoria da inflação inercial. Homem de ação, no setor privado e no setor público, Bracher tem trajetória que ilumina a superação de dificuldades presentes na política econômica nacional.
An ecological view of New Developmentalism: a proposal of integration
Authors: GUARINI GIULIO , OREIRO JOSÉ LUIS
Published: January 2022

ABSTRACT Article aims to integrate New Developmentalism with Ecological View by means of the concepts of Ecological Structural Change (ESC) and Eco-Developmental Class-Coalition (EDCC). ESC means to increase the share of green manufacturing sector in GDP and employment for increasing the environmental efficiency of the economy. Exchange rate overvaluation caused by Dutch disease and growth with foreign savings can harm green manufacturing industries even more than brown manufacturing industries. ESC needs the existence of an EDCC that can be made difficult to occur if exchange rate over-valuation is not removed through taxes over commodities exports, capital controls and a dual mandate for the Central Bank.
Perspective of pediatricians and adolescent patients on the transition process in a university hospital
Authors: Silva Luiza Mariana Cordeiro , Souza Letícia Mansano , Andrade Elizete Prescinotti , D’Souza-Li Lilia
Published: January 2022

ABSTRACT Objective: To map the transition process from the perspective of pediatricians and their adolescent patients, and to suggest a transition protocol. Methods: This is a descriptive, cross-sectional study conducted in a pediatric outpatient clinic of a public tertiary hospital. Pediatricians answered a questionnaire about the transition process, and that was evaluated in a descriptive manner. The Transition Readiness Assessment Questionnaire (TRAQ) on health autonomy was answered by the adolescents and the analysis was performed using the χ2 and Mann-Whitney tests. p<0.05 were considered significant. Results: 31 pediatricians (16 residents, 15 supervisors) were enrolled, with a mean age of 40.1 (±16.9), 87% women, with years working in Pediatrics ranging from 2 to 45 years (median of 5 years). Most doctors agreed that there was no transition plan, but they stimulated the patient’s autonomy and talked to the patient and family members about any existing chronic diseases. A total of 102 adolescent patients participated, with a median age of 15; 56% were female. The TRAQ median was 58, with similar scores between females and males, and higher scores in those older than 16 years of age (Mann-Whitney U test, p=0.01). The patients reported ease in face-to-face communication with their doctors, but great difficulty in talking about health issues over the phone. Conclusions: Even without a transition protocol, adolescents developed several self-care skills as they aged. The lack of a transitional protocol led to conflicting opinions, which reinforces the need for improvement. We suggest a flowchart and transition protocol.
Do children’s previous physical activity habits influence their behaviors during the Covid-19 social distancing period?
Authors: Siegle Cristhina Bonilha Huster , Pombo André , Luz Carlos , Rodrigues Luis Paulo , Cordovil Rita , Sá Cristina dos Santos Cardoso de
Published: January 2022

Abstract Objective: Verify whether the practice of physical activity, before the social distancing imposed by COVID-19, influences children’s routines during this period, in children of different ages. Methods: Descriptive cross-sectional study carried out with an online questionnaire from LimeSurvey and disseminated for four months during social distancing. The questionnaire contained questions about family composition, household characteristics, household and children’s routines, including habits such as sleeping, physical activity, intellectual activity, playing with and without physical activity, and screen time. The final sample consisted of 916 participating families that answered about the physical activity habits of their respective children before the pandemic. Children were divided into three age groups (three to five years, six to nine years, and ten to twelve years). Independent Student’s t-tests were performed to investigate whether the previous practice of scheduled physical activity group and the no physical activity group differed as to the time dedicated to children’s activities and routines (intellectual activity, sleeping, screen time, playing with and without physical activity), by age groups, during social distancing. Results: There was a decrease in the levels of physical activity undertaken by Brazilian children during social distancing. There was no difference when both groups. The children with previous practice of scheduled physical activity did not display different habits from the children who did not adopt this practice. Conclusions: The practice of physical activity before social distancing did not influence the level of physical activity and other habits during social distancing. Healthy habits should be encouraged and targeted for all children during the pandemic. These findings can contribute to the formulation of public policies for children during pandemic times.
Assessment of time-dependent structural resistance of RC bridges in Barak Valley, Assam, India
Authors: Das Joydeep , Sil Arjun
Published: January 2022

Reinforced concrete (RC) bridges deteriorate due to strength loss induced by aging of the structure, extreme weathering conditions and unplanned increased service loads. These load variations and aging factors can compromise structural reliability and reduce the service life for continuous satisfactory operation of service bridges in the future. Accurate prediction of bridge functionality relies on reasonable models of bridge strength and applied loads, and time-dependent reliability assessments can be used to gain a reliable understanding of bridge conditions so that appropriate solutions can be found. In this work, the reliability of bridges under harsh conditions was studied using time-variant and time-invariant reliability models in which both load and resistance are considered as time-dependent parameters. Combinations of the condition rating and time-dependent load were used to gain accurate insights into the degradation of the structural resistance of existing bridges. The results of this study showed the significant impact of aging and the influence of traffic loads on the service life of both national highway bridges and rural road service bridges. These observations could be used to devise appropriate planning strategies and plan rational decisions to ensure bridge safety in the future.