bluuebunny/crossref_metadata_2025 huggingface dataset:
Using a method that combines genomics and systems biology, CDKN2A is identified as a possible indicator of survival in liver cancer
Authors: Chen Xueqin , Zhao Ruonan , Wang Ruiping , Zhang Rongqiang
Published: December 2024

[Abstract] Objective The prognostic implications of cuproptosis-related genes (CRGs) in hepatocellular carcinoma (HCC) are still uncertain, as cuproptosis is a recently discovered programmed cell death mechanism in tumors.
Methods CRGs from TCGA were obtained and then screened based on their strong correlation with the expression matrix of lncRNA associated with cuproptosis in patients with HCC. LASSO-COX regression models were developed using data from the cancer genome atlas (TCGA) and the international cancer genome consortium (ICGC) databases to discover a prognostic signature related to cuproptosis. The models' accuracy was evaluated using Kaplan-Meier curves and ROC models. The prognostic signature related to cuproptosis was evaluated for its ability to predict outcomes in HCC through various survival models including OS, PFS, DFS, and DSS. To further investigate the prognostic signature related to cuproptosis in hepatoma cell lines, quantitative real-time PCR (qRT-PCR) and western blot techniques were utilized. It was then preceded by studying the proliferation, migration, and invasion through CCK-8 and transwell assays, while flow cytometry was used for studying apoptosis. The tumorigenesis in hepatoma cell lines concerning a cuproptosis-related prognostic signature was further studied using the lentivirus transfection method and a subcutaneous transplantation model.
Results The study results indicated that CDKN2A was the crucial prognostic signature for HCC, in addition to highly expressed mRNA and proteins in hepatoma cell lines. The CDKN2A was determined as an independent variable distinguishing it from other HCC clinical features. CDKN2A knockdown not only inhibited the proliferation, migration, and invasion of hepatoma cell lines, but also arrested cell growth in the G2/M phase and promoted cell apoptosis. It precluded the growth of subcutaneous tumors in naked mice.
Conclusion In this study, three original prognostic models for HCC were established based on identifying a cuproptosis-related prognostic signature, validated using cell assays and nude mice subcutaneous transplantation models. Thus, CDKN2A could potentially become a new target for treating HCC, providing a theoretical basis and recommendations for utilizing CRG targets in HCC therapy.
Understanding Attitudes Toward Zoster Vaccination in the Hospital Setting: A Multidisciplinary Model to Contrast Vaccine Hesitancy in Fragile Patients. A prospective longitudinal observational study
Authors: Martinelli Silvia , Regazzi Luca , Rizzo Federica , Tamburrini Enrica , Salvo Pierluigi Francesco , Bosello Silvia Laura , Landi Francesco , Sica Simona , Spadea Antonietta , Pascucci Domenico , Laurenti Patrizia
Published: December 2024

Introduction:
The efficacy of recombinant adjuvanted vaccine (RZV) against Herpes Zoster (HZ) is universally recognized and is the only safe vaccine in immunocompromised persons and in higher-risk individuals. Higher-risk patients with primary or acquired immunodeficiencies are characterized by an increased risk of disseminated infection after HZ infection or after reactivation of HZ virus, due to their clinically fragile condition. To date, the rate of vaccination with RZV through non-hospital health services in this population does not reach optimal standards, either because of difficulties in accessing care or because of vaccine hesitancy (VH). According to the latest international guidelines, interventions to support community medicine are needed to increase vaccination coverage and to counteract VH.
Methods
The Fondazione Policlinico Universitario Agostino Gemelli IRCCS Hospital in Rome performed an organizational management model including the hospital and non-hospital health services (ASL Roma 1) dedicated to vaccine counseling and contrasting VH in frail patients with an indication for RZV vaccination. Multiple linear regression was used to analyze the impact of results.
Results
From July 2022 to July 2023, 178 patients underwent vaccine counseling and received two doses of RZV vaccine, of which, 90 responded to the recall to evaluate side effects, breakthrough HZ Infections and answered to the VAX Scale questionnaire. 34.27% were affected by HIV infection, 23% by HZ relapses or severe forms, and 21.35% by rheumatologic diseases. Total VH score tot 2.291. A statistically significant correlation was demonstrated between age/rheumatology patients/female sex and overall vaccine hesitancy. 80% and 74.44% of patients had no short-term side effects after the first and second doses, respectively. 3.33% had breakthrough HZ Infections. No patients had minor or major long-term (1 year) side effects. Comparison of responses to VAX scale in the first and recall phase, showed positive changes about VH, with differences ranging from 2.9 to 3.0 points.
Conclusions
This study demonstrates that a multidisciplinary approach to vaccine counseling can significantly reduce vaccine hesitancy and improve adherence among frail, high-risk patients.
Trial registration:
ClinicalTrials.gov ID: NCT06334861; date of registration: 2023-03-13
Predictive Modeling for Healthcare: Leveraging Categorical and Binary Data for Enhanced Accuracy
Authors: Saxena Tanuj , Maurya Ujjwal
Published: December 2024

Such dramatic growth in healthcare data has increased the necessity of developing predictive models capable of manipulating and processing categorical and binary data, which would constitute significant improvements in the predictability of diseases and patient management strategies. Traditional statistical approaches such as Logistic Regression have been utilized frequently but often fail when managing these complex relationships inherent to large health care datasets. Several studies recently shown that, in comparison with traditional methods, advanced machine learning techniques such as Random Forest, CatBoost, and Gradient Boosting can better capture complex, non-linear patterns and data interactions toward a high level of predictive accuracy. This paper systematically applies and evaluates these new techniques on healthcare datasets while focusing on the optimization of main performance metrics: accuracy, sensitivity, and specificity. Experimental results demonstrate that ensemble models, especially CatBoost, outperform traditional models in terms of prediction accuracy, and thus can be adapted to robust solutions in patient risk classification and early detection of diseases. The findings imply the importance of advanced machine learning methods in supporting the personalization of treatment plans and allocation of resources, leading towards exact, data-driven decision-making in healthcare systems.
Guided phase transition for mitigating voltage hysteresis of iron fluoride cathode materials in lithium-ion batteries
Authors: Jung Sung-Kyun , Jo Hyoi , Gong Minjeong , Kim Se Young , Seo Dong-Hwa
Published: December 2024

Despite the high capacity attained by conversion-reaction-based metal-fluoride cathode materials in lithium-ion batteries through multiple electron storage, the large voltage hysteresis and low structural reversibility constrain their use. Herein, we propose guided phase transitions for designing conversion cathode materials that undergo minimal structural changes upon lithium-ion storage. This approach reduces the compositional inhomogeneity, a culprit of the voltage hysteresis, while providing high structural reversibility. Unlike the thermodynamically stable rhombohedral FeF3 (R-FeF3), which suffers from irreversible phase transitions accompanied by drastic structural evolution, tetragonal FeF3 (T-FeF3), a thermodynamically metastable phase guided by fluoride-ion incorporation into FeF2 from the electrochemical splitting of LiF, undergoes facile and reversible phase transitions during intercalation and conversion reactions by sustaining its structural integrity upon charge and discharge. Our research provides valuable insights into the significance of avoiding an irreversible reaction pathway and inducing it to minimize changes in the crystal structure for the design of conversion cathode materials with low voltage hysteresis and excellent cycle stability.
A high-resolution compound vulnerability function for European winter storm losses
Authors: Ederen D. , Cerda S. Fonseca , Botzen W. J.W. , Aerts J. C.J.H. , Lupi V. , Scussolini P. , Gubbels K. B.
Published: December 2024

Economic losses from European winter storms impose a significant burden on society and are expected to increase due to exposure growth and climate change. Vulnerability functions play a key role in estimating such losses as they describe the relationship between a natural hazard’s intensity and damage to the exposed asset. This study fills an important gap in the literature by providing a vulnerability function for residential buildings which, for the first time, is able to account for damage from both the wind and the precipitation that winter storms produce. This compound vulnerability function is estimated using truncated beta regressions, and based on a large number of object-level insurance claims from The Netherlands and ultra-high resolution meteorological observations. Comparing our vulnerability function to the conventional specification, which only considers damage from wind, shows that the latter underestimates the damage by 5% [21%] {57%} for winter storms with 24-hour cumulative precipitation levels of 50 mm [75 mm] {100 mm}. Given that climate change is projected to further increase the frequency and intensity of such precipitation extremes in Europe, our study provides evidence in favor of using compound vulnerability functions to estimate future winter storm losses more accurately. Our vulnerability function can be used in natural catastrophe models to accurately estimate damage to residential buildings from European winter storms.
The Development of Data Structures for Preventing Data Loss and Enhancing Data Analysis in Distributed Communication Networks
Authors: Supamid Tipaporn , Wongkumsin Suwit
Published: December 2024

In the contemporary digital landscape, distributed communication networks are integral to the transmission of data and the interconnection of various devices. Nevertheless, a prevalent issue encountered is the phenomenon of data loss during transmission, which complicates the analysis of the data obtained from these networks. This research endeavor is centered on the formulation of a data structure aimed at mitigating data loss and enhancing the efficacy of data analysis. The architecture integrates mechanisms for data encryption, data replication, and error detection to uphold data integrity. Furthermore, methodologies for parallel processing and task distribution are employed to adeptly manage extensive and intricate datasets. The investigation revealed that this methodology has the potential to diminish data loss by 30% and augment data analysis efficiency by as much as 90%, thereby facilitating a more stable and effective operation of distributed communication networks.
Impact of Introducing an Advanced Care Paramedic Program on Clinical Outcomes for Out-of-Hospital Cardiac Arrest Patients Transported to Hospital
Authors: McGraw Mark , Chandra Kavish , Mekwan Jay , Fraser Jacqueline , McDougall Pamela , Pishe Tushar , Atkinson Paul
Published: December 2024

Introduction:
Out-of-hospital cardiac arrest is a leading cause of mortality. Timely advanced life support, including the administration of epinephrine, improves clinical outcomes. This study evaluated the impact of introducing an advanced care paramedic program on key clinical outcomes, including return of spontaneous circulation, survival to hospital admission, and survival to hospital discharge.
Methods:
A retrospective health records review was conducted on patients with out-of-hospital cardiac arrest transported to a tertiary Canadian hospital. Patients were included if they were transported by emergency medical services to the emergency department between January 2010 and March 2019. Exclusion criteria included age under 18 years, arrest in the emergency department, trauma, or overdose-related arrests. Data were analyzed using chi-square tests, with a p-value <0.05 considered statistically significant.
Results:
Of the 390 patients identified, 228 (58.5%) from the pre-advanced care paramedic cohort and 162 (41.5%) from the post-advanced care paramedic cohort were included. Following the introduction of the advanced care paramedic program, return of spontaneous circulation was achieved by 67 out of 162 patients (41.3%) in the post-implementation group compared to 72 out of 228 patients (31.6%) in the pre-implementation group (OR 1.5, 95% CI 1.0-2.3, p=0.05). Survival to hospital admission increased from 34 out of 228 patients (14.9%) to 40 out of 162 patients (24.7%) (OR 2.0, 95% CI 1.2-3.3, p=0.015). Survival to hospital discharge increased from 7 out of 228 patients (3.1%) to 18 out of 162 patients (11.1%) (OR 4.8, 95% CI 2.0-11.5, p<0.001).
Conclusion:
The introduction of a regional advanced care paramedic program significantly improved clinical outcomes for patients experiencing out-of-hospital cardiac arrest. These findings support the integration of advanced care paramedics into prehospital care protocols.
RESILIENCE AND PERSISTENCE OF POLITICAL DYNASTIES: THE CASE OF THE CHASAN SOCHIB FAMILY IN BANTEN, INDONESIA
Authors:   Universitas Islam Syekh-Yusuf, Tangerang, Indonesia., Ferry Bastian Asep
Published: December 2024

This paper examines the emergence, consolidation, and persistence of the political dynasty led by Tubagus Chasan Sochib in Banten, Indonesia. Rooted in local culture and power structures, the dynasty established its influence initially through economic ties and expanded into political dominance under Sochibs daughter, Ratu Atut Chosiyah, Bantens governor. Chasans rise began with business ventures tied to the local military, growing his influence through prominent regional organizations and strategic appointments. His familys political reach continued under Ratu Atut and expanded into a formidable network spanning both political and business spheres in Banten. Despite significant corruption charges against family members, the dynasty has endured and maintained substantial influence over local governance. This paper explores the mechanisms that have enabled the dynastys persistence, focusing on local cultural leadership norms, historical alliances with political entities, and strategic maneuvering within Bantens power landscape. Through a systematic literature review, the research synthesizes findings on patronage, clientelism, and dynastic politics within the context of Bantens political landscape. This study seeks to answer how the Chasan Sochib dynasty has retained its hold on political power in Banten, revealing insights into the resilience of political dynasties within Indonesias evolving democratic framework.
AN EMPIRICAL ANALYSIS OF THE FACTORS INFLUENCING THE EMPLOYMENT WILLINGNESS OF VOCATIONAL COLLEGE GRADUATES BASED ON THE MLR MODEL A CASE STUDY OF 49 VOCATIONAL COLLEGES IN ZHEJIANG PROVINCE
Authors:   Zhejiang Industry & Trade Vocational College., Zhu Haiying , Wei Jintong ,   Zhejiang Industry & Trade Vocational College.
Published: December 2024

This study empirically analyzes the factors influencing the employment willingness of vocational college graduates in Zhejiang Province, using graduates from 49 vocational colleges as the survey group. The analysis is based on four aspects: social factors, school education, family beliefs, and personal abilities. The research findings indicate that personal abilities and social factors have a significant positive impact on the employment willingness of vocational college graduates, while school education and family beliefs also positively influence their employment willingness. Therefore, it is recommended to enhance individuals core competitiveness, establish employment-related policies for graduates at the societal level, provide targeted employment guidance for graduates at schools, and promote the development of sound career selection concepts within families.
DIFFICULTIES AND COPING MECHANISMS OF CRIMINOLOGY INSTRUCTORS HANDLING NEW SUBJECTS UNDER COMMISSION ON HIGHER EDUCATION MEMORANDUM ORDER NO. 5 SERIES OF 2018(CMO 5, S. 2018) AMONG STATE COLLEGES AND UNIVERSITIES (SUCs) OF CORDILLERA ADMINISTRATIVE REGION (CAR)
Authors:   University of Baguio School of Criminal Justice and Public Safety General Luna Road, Baguio City, Philippines., L. Danglosi Eric
Published: December 2024

The new curriculum is implemented to align education with the current needs of our society and environment. In this implementation, the criminology instructors faced difficulties in handling the new subjects. The researcher used descriptive-qualitative research in this study. Unstructured interview guide questions were used to identify and describe the difficulties faced by the criminology instructors and their coping mechanisms. The five (5) participants of this study are Criminology faculty members of SUCs of CAR offering BS Criminology Program who are currently teaching new subjects provided by the new curriculum (CMO 5 s. 2018). The results revealed that the participants experienced difficulties due to inadequate resources in their institutions and the lack of information about the new subjects assigned to them. With these difficulties, the criminology instructors became creative and adaptable to the changes. The participants cope with these difficulties by doing advanced reading about the subject, collaborating with other institutions, and attending training and seminars to enhance their teaching effectiveness.
REFERÊNCIA E CONTRARREFERÊNCIA NAS MICRORREGIÕES DE SAÚDE DE MANHUAÇU E CARANGOLA
Authors: Matheus Rondel Leite  , Cristiano Inácio Martins  , Marceli Schwenck Alves Silva  , Éntero Benvindo
Published: December 2024

Estudo com abordagem quantitativa de finalidade descritiva, onde aplicou-se um questionário destinado aos gestores dos municípios a fim de conhecer a rede de referência e contrarreferência das microrregiões de saúde de Manhuaçu e Carangola e descrevê-las. Os municípios pertencentes às microrregiões pesquisadas não possuem uma rede de referência e contrarreferência integrada, causando problemas na rede de atenção à saúde, caracterizada pela falta de implementação de ouvidorias de saúde, territorialização desatualizada, referência e contrarreferência inadequada e falta de integração das redes de saúde entre os municípios. Sugere-se implementações de definição de direcionamentos no sistema, gestão e capacitação humana aprimorada e intercomunicação entre os setores, realizando assim a implementação integral e eficaz do sistema de referência e contrarreferência nas microrregiões de saúde de Manhuaçu e Carangola.
AVALIAÇÃO PRECOCE DA SENSIBILIDADE AO ALUMÍNIO DE HÍBRIDOS DE MILHO EMPREGANDO TESTE DE GERMINAÇÃO
Authors: Gustavo de Freitas Mafort  , Samuel Ferreira Ribeiro  , Ariana Elisa Rodrigues Marteline  , Glaucio Luciano Araujo  , Wagner Nunes Rodrigues
Published: December 2024

O presente trabalho foi desenvolvido com o objetivo de comparar possíveis níveis de tolerância ou sensibilidade ao alumínio de diferentes híbridos de milho, considerando o efeito desse elemento sobre a germinação de suas sementes. Para tal, foi realizado um experimento envolvendo um teste de germinação de híbridos de milho e condições contrastantes para o alumínio. A germinação das sementes foi influenciada pelas condições de alumínio no meio e pela diferença genética entre os híbridos, demonstrando interação significativa entre esses fatores. Notou-se um efeito detrimental do alumínio sobre a germinação das sementes de milho. Apesar de alguns híbridos não apresentarem limitação na proporção de sementes germinadas, a presença de alumínio causou limitação do crescimento de radículas e coleóptilos. Os híbridos P4285VYHR e ExtendaxRR2 se destacaram por emitirem radículas relativamente maiores do que os demais na presença de alumínio, enquanto AS1868PRO4, SS204EVIP3 e BM855PRO2 foram mais sensíveis ao alumínio.
Physical activity in patients with chronic venous insufficiency: Its relation with disease severity, pain, fatigue, and functionality
Authors: Aydın Gamze , Aloğlu Çiftçi Ebru , Atıcı Emine , Akgöl Ahmet Cüneyt , Tuncer Mehmet Altuğ
Published: December 2024

Purpose: Chronic venous insufficiency (CVI) is a progressive disease of the venous system caused by a variety of factors that impair the return of venous blood to the heart. The aim of the study was to evaluate the physical activity level in patients with CVI and its relation with disease severity, pain, fatigue, functionality.
Methods: In all, 105 CVI patients (28.6% male, 71.4% female, mean age was 44.91±10.74 years) were enrolled in this study. Physical activity was evaluated with the International Physical Activity Questionnaire-Short Form (IPAQ-SF); disease severity, by Venous Clinical Severity Score (VCSS); the intensity of pain was determined by the Visual Analog Scale (VAS); fatigue level with the Fatigue Severity Scale (FSS); functionality was assessed with the Lower Extremity Function Scale (LEFS).
Results: There was a significant negative correlation between IPAQ-SF-vigorous and VCSS, VASrest, VASactivity, VASnight (r: -0.818, p
Relação entre desempenho e custos no setor público: um estudo nas universidades federais do brasil
Authors:   , Menezes Aline Kelly de
Published: December 2024

A busca pela eficiência tem provocado discussões a respeito de mecanismos que subsidie na gestão dos recursos públicos, cada vez mais escassos. Nesse sentido, medidas de desempenho e sistemas de informações de custos têm se mostrado importantes instrumentos de governança, capazes de produzir informações gerenciais úteis para o planejar, controlar e decidir com maior eficiência, além do fornecimento de informações que contribuem para a transparência da gestão. O objetivo geral do presente trabalho é analisar a relação entre desempenho e custos nas universidades federais do Brasil. O estudo é caracterizado como uma pesquisa do tipo exploratória, descritiva, bibliográfica e documental, já a abordagem do problema foi através da pesquisa quantitativa. Os dados para aferição dos custos foram coletados das Variações Patrimoniais Diminutivas das universidades, obtidas por meio dos Balancetes contábeis, solicitados pelo Serviço de Informação ao Cidadão, e para o desempenho foram coletados os 09 (nove) indicadores de desempenho do Relatório de Gestão recomentados pelo TCU e o indicador IGC obtido no site do INEP/MEC, todos para o período de 2015 a 2017. Para atingir o objetivo geral, primeiramente, foi mensurado os custos das universidades através da metodologia de Santos (2014). Com o custo total obtido foi efetuado o rateio pelo quantitativo de alunos equivalentes, resultando no Custo por aluno equivalente, com objetivo de minimizar os efeitos do porte da universidade. Em seguida foi realizada uma análise descritiva dos 10 (dez) indicadores de desempenho, para, por fim, ser realizada a análise de correlação entre desempenho e custos. Os resultados sugerem que existe relação entre desempenho e custos nas universidades federais do Brasil, na medida em que dos 10 (dez) indicadores de desempenho utilizados na pesquisa, 07 (sete) tem correlação estatisticamente significante com os custos, sendo 06 (seis) correlações positivas e moderadas e 01 (uma) correlação negativa e fraca. Outro achado importante dessa pesquisa foi na análise regional, onde as regiões sul e sudeste possuem os maiores custos por aluno equivalente, mas também os melhores valores para a maioria dos indicadores de desempenho, em especial os que são positivamente correlacionados com os custos, sugerindo que os investimentos nas universidades afetam seus resultados, concedendo retorno em melhores desempenhos. Por fim, o resultado mostra que o conhecimento da relação entre desempenho e custos é importante fonte de informação para os gestores públicos e para a identificação da eficiência na aplicação dos recursos públicos.
MODELO DE EMPREENDEDORISMO, INOVAÇÃO E PROPRIEDADE INTELECTUAL VOLTADO PARA AS UNIVERSIDADES PÚBLICAS
Authors: Silva Amanda Luiza Soares , Aragão Iracema Machado de , Felizola Matheus Pereira Mattos
Published: December 2024

As universidades públicas brasileiras realizam diversas atividades de empreendedorismo, inovação e propriedade intelectual como cursos, empresa júnior, Centros de Empreendedorismo, Núcleos de Inovação Tecnológica – NITs etc. Elas também enfrentam diversos desafios relacionados ao baixo investimento do Produto Interno Bruto (PIB) em Ciência, Tecnologia e Inovação (C, T & I) a burocracia, a dificuldade de transferir tecnologia para o mercado e as poucas parcerias com os integrantes do Ecossistema Empreendedor. Por isso, este estudo tem como objetivo construir e validar um modelo empreendedorismo, inovação e propriedade intelectual voltado para as universidades públicas. Em relação à metodologia, o método é o survey e foi aplicado um questionário estruturado com professores de universidades públicas federais e estaduais das temáticas de empreendedorismo, inovação e propriedade intelectual, sendo que se utilizou a modelagem de equações estruturais para examinar as relações entre as variáveis latentes. Quanto aos resultados, teve-se 80 respondentes dos quais 73 eram professores, 38 coordenadores de projetos de pesquisa e 36 membros desses projetos. A maior parte dos respondentes foi da Região Nordeste. Após os ajustes estatísticos, foi possível obter duas hipóteses aceitas e validar um modelo adequado para as atividades de empreendedorismo, inovação e propriedade intelectual voltado para as universidades públicas brasileiras.
Evaluating the Perceptions of Smile Aesthetics among Dental Students at King Abdul-Aziz University: A cross-Sectional Study
Authors: Sajini Shara I. , Abdelmaksoud Heba , Abuljadayel Roaa , Habis Reema , Shafi Lina
Published: December 2024

Background

Individuals seek out cosmetic dentists not so much for improved dental function or overall health but rather to improve the appearance of their teeth and gain more social acceptance. This study aimed to evaluate how dental students at King Abdul-Aziz University (KAU) perceived smiles based on their gender.

Methods

The study included two hundred students with clinical experience from the College of Dentistry, KAU. The data were collected using a three-part validated questionnaire. The first part included socio-demographic items; the second part included two close-ended questions regarding aesthetic characteristics; and the third part consisted of perception to seventeen photos of digitally manipulated smiles to be assessed using a numeric rating scale (NRS), (1, best; 5, worst).

Results

The first facial feature to catch the attention of most students was a smile, which was followed by the eyes. Almost 98% of the participants considered the smile one of the most important features of facial aesthetics. According to Faradeni research, men valued their gingival smile characteristic (p=0.013) and teeth color (p=0.001) substantially higher than women.

Conversely, females had higher crucial margin discrepancy (p=0.038) and convex occlusal plane (p>0.001) than males.

Conclusion

When it comes to the gingival smile, teeth color, and the initial facial feature that attracts the eye, women perceive smiles as more aesthetically pleasing than men. Gingival margin discrepancy and convex occlusal plane were more critical in males than females. Understanding smile aesthetics from the perspective of dental students enhances patient care, education, and overall treatment outcomes.
STUDY ON VACCINE COLD CHAIN MANAGEMENT ROUTINE IMMUNIZATION IN THE SERIBU ISLANDS DKI JAKARTA 2024
Authors:   Universitas Indonesia Maju, Huriyati Huriyati
Published: December 2024

Vaccines are biological components with special characteristics and are important products in immunization programs, which are efforts to prevent diseases, disabilities, and deaths caused by vaccine-preventable diseases (VPD) in children and adults. This research study aims to benefit the advancement of immunization programs and pharmacy programs in vaccine management so that the immunization goal of enhancing the immunity of the Thousand Islands community against VPD can be achieved. Qualitative research method with a phenomenological research design, structured observation of ongoing management accompanied by interviews and document review. The research variables are cold chain equipment, temperature management, and vaccine inventory. The results of the cold chain equipment study show that 5 community health centers have conducted routine maintenance, while 2 community health centers have not conducted routine maintenance. Temperature management is carried out according to guidelines, but one health center does not record temperatures regularly. In the vaccine inventory, all health centers stored vaccines longer than the duration specified in the guidelines, and vaccines with VVM C were found in one health center. The cold chain management for routine immunization vaccines in the Thousand Islands has adequate cold chain equipment readiness.
FACTORS ASSOCIATED WITH MASK USE BEHAVIOR AMONG WORKERS OF THE KATARAJA TOLL ROAD CONSTRUCTION PROJECT IN 2024
Authors:   Islamic State University Syarif Hidayatullah Jakarta, Handayani Puji , Iriani Dewi Utami
Published: December 2024

In toll road construction projects, some jobs cause high levels of Particulate Matter, such as breaking, road cleaning, and others. Thus, workers must use masks, such as KN95, KF94, or N95 masks. According to the Health Belief Model (HBM) theory, mask-use behavior is influenced by perceived threat, perceived benefits, perceived barriers, self-efficacy, cues to action, and sociodemographics. This study aims to determine the factors associated with mask-use behavior among workers of the Kataraja section 1 toll road construction project in 2024. The study design used was cross-sectional with a sample size of 70 workers taken by purposive sampling. Data collection was carried out using a questionnaire with interview techniques. The data obtained were analyzed using univariate and bivariate analysis with the Chi-Square test. The results showed that 44.3% of workers had poor mask use behavior, such as not washing hands before using a mask, not changing masks regularly, and not disposing of mask waste in its place. There is a significant relationship between education level (OR=81), knowledge level (OR=11), perceived threat (OR=8.31), perceived benefits (OR=59.06), perceived barriers (OR=7.32), self-efficacy (OR=38.85), and the role of supervisors (OR=10.17) with mask use behavior. To improve poor behavior in workers, companies need to provide informal education regarding the dangers of Particulate Matter and the benefits and procedures for using masks. In addition, workers still find it difficult to change masks, so companies should pay attention to
the quality and quantity of masks and make it easier for workers to take
POTENSI PENGAMBANGAN SENTRA PETERNAKAN KAMBING ETAWA DESA BANGELAN, KECAMATAN WONOSARI, KABUPATEN MALANG
Authors: Waloejo Budi sugiarto , Meidiana Christia , Agustin Imma widyawati , Sutikno Fauzul rizal , Yudono Adipandang , Wirawati Triska Ludya , Fiona Meutia
Published: December 2024

This service activity aims to unlock the potential and development opportunities of Bangelan Village, one of which is Goat Farming. The majority of people's livelihoods are farming and animal husbandry. Almost all the people in Bangelan Village have around 20 goats. One of the livestock groups in Bangelan Village is the Karya Mulya Livestock Group. However, they face obstacles in the form of feed and livestock pens that are not used optimally. Forage is difficult to find, especially in the dry season, so it is necessary to stock food so that farmers do not have difficulty finding feed in the dry season. The cage used is also a traditional cage that has been passed down from our ancestors. The methods applied in this service activity include tracing and interviews with the Karya Mulya Community and Livestock Group. The final results show several plans that will be carried out to resolve existing problems. In conclusion, the Karya Mulya livestock group in Bangelan Village was successful in determining a way to resolve the livestock problem.
Penggalian Potensi Pariwisata Desa Bangelan Sebagai Upaya Peningkatan Perekonomian Di Kecamatan Wonosari ,Kabupaten Malang
Authors: Meidiana Christia , Sutikno Fauzul rizal , Sari Kartika eka , Firdausiyah Nailah , Wirawati Triska Ludya , Rahim Sentanu Wisesa
Published: December 2024

One of the villages in Wonosari Subdistrict that has a lot of tourism potential is Bangelan Village. This village has an area of 167.20 hectares. Tourism in Bangelan Village utilizes the natural beauty of the village, namely the Tanaka Waterfall tourist attraction located in Arjomulyo Hamlet and jeep tours. This village is the focus of research because of the existence of tourism areas that play an important role in driving the economy of the local community. By using a qualitative descriptive method, it is expected that the tourism potential in Bangelan Village can be explored optimally. This research aims to explore the potential and development opportunities of Bangelan Village, especially in the context of Tourism managed by the Bangelan Village Community. The results showed that Bangelan Village has many tourism potentials that can be developed. Tourism development must be accompanied by good management from the community. Tourism development is expected to encourage the improvement of the community's economy in Bangelan Village.
Pemanfaatan Tenaga Surya Untuk Penerangan Di Desa Oro-Oro Ombo
Authors: Hamidi Nurkholis , Wardana ING
Published: December 2024

Oro-Oro Ombo Village is located in the Batu Malang area, East Java, Indonesia, and is famous for its culture, architecture, and beautiful environment. Located on the hillside of Panderman Mountain, this village has a landscape dominated by terraced rice fields, vegetable gardens, and fruit orchards. This village is located on a plateau with winding roads, many rivers, and trees which make agriculture and plantations the livelihood of most of the village residents. However, the lack of street lighting in this area can raise security concerns for residents who are active at night. Apart from that, the problem of minimal education regarding waste processing is a matter of concern, so there is a need for education and outreach regarding this matter to increase public awareness and understanding regarding sustainable waste management practices. To overcome the problem of street lighting, a community service activity will be carried out to design and construct street lighting in Oro Oro Ombo Village by utilizing solar energy as an alternative energy. This activity also includes training and mentoring village residents to understand the working principles of solar power plants, so that residents can carry out the necessary maintenance. Street lighting aims to improve public safety, promote economic development, and improve the overall quality of life in rural areas.
Social Movements and Digital Appropriation in Latin America and the Caribbean
Authors: González-Véliz Constanza
Published: December 2024

The article explores the dynamics of digital appropriation by social movements in Latin America and the Caribbean. It highlights how, in recent decades, information and communication technologies have transformed the political and social landscape of the region, providing new opportunities for organization, mobilization, and citizen participation. These digital tools have provided social movements with new forms of dissemination of information, allowing the creation of networks of solidarity and resistance at the local, national, and even international levels. Through strategies such as cyberactivism and cyberfeminism, social movements have used digital platforms to challenge the status quo and promote social justice. However, the challenges and obstacles they face, such as digital divides, online censorship, and the influence of extremist anti-rights groups, are also addressed. Despite these challenges, social movements have demonstrated a remarkable ability to adapt and leverage digital tools to pursue their goals of social justice and political change. The transformative potential of digital appropriation is highlighted, reflecting the region’s socioeconomic, political, and cultural realities. The diversity of approaches and strategies social movements use shows the region’s complexity and richness of social struggles. Addressing structural inequalities and promoting collective action to build more just and equitable societies is ultimately emphasized.
ОСОБЛИВОСТІ ЗАСТОСУВАННЯ БЕТА-БЛОКАТОРІВ У ПАЦІЄНТІВ З ХРОНІЧНОЮ СЕРЦЕВОЮ НЕДОСТАТНІСТЮ І СИНДРОМОМ НИЗЬКОГО ТРИЙОДТИРОНИНУ, ЯКІ ПЕРЕНЕСЛИ КОРОНАВІРУСНУ ІНФЕКЦІЮ (огляд літератури та власні дані)
Authors: Рудик Юрій , Пивовар Cергій , Щербань Тетяна , Удовиченко Марина , Лозик Тетяна
Published: December 2024

Дана робота присвячена дослідженню особливостей застосування β-адреноблокаторів (БАБ) у разі поєднання хронічної серцевої недостатності (ХСН) з синдром низького трийодтироніну (СНТ) та перенесеною коронавірусною інфекцією, яка чинить значний вплив на стан серцево-судинної системи. Різке зростання смертності в період пандемії COVID-19 показало, що серцева недостатність є фактором несприятливого прогнозу у пацієнтів з COVID-19. Також ризик смерті пацієнтів із COVID-19 та низьким рівнем трийодтироніну вільного (Т3в) на 33% вищий порівняно з особами з нормальним рівнем Т3в. У понад 25% хворих з COVID-19 діагностували СНТ. СНТ можна вважати індикатором несприятливого прогнозу в пацієнтів із ХСН. З метою виявлення залежності ризику повторних госпіталізацій пацієнтів з ХСН зі зниженою фракцією викиду лівого шлуночка (ФВЛШ) від тривалості титрування дози бісопрололу до 5 мг на добу був проведений ROC-аналіз. Встановлено, що частота повторних госпіталізацій в групі пацієнтів з ХСН без СНТ є очікувано вищою при дозі бісопролола 1,25-5,0 мг порівняно з дозою БАБ понад 5 мг. Також застосування бісопролола в добовій дозі >5 мг у пацієнтів зі зниженою ФВЛШ та супутнім СНТ не сприяє покращенню перебігу ХСН, не призводить до зниження частоти повторних госпіталізацій у зв`язку з підвищенням ризику декомпенсації ХСН. Тобто, ефект застосування бісопролола при СНТ зворотній: ризик повторних госпіталізацій зростає при підвищенні добової дози БАБ понад 5 мг, при цьому відзначається подальше зниження рівня Т3в у сироватці. Імовірно, пацієнтам з ХСН на тлі СНТ недоцільно титрувати дозу бісопролола вище 5 мг і тривалість титрування не повинна бути меншою 63 днів. Проведено літературний пошук з використанням баз даних Web of Science, Scopus, The Cochrane Library, MedLine, EMBASE, Global Health та ін.
Unveiling the Evolutionary Trajectory of SMEs in the Tourism and Hospitality Domain: A Comprehensive Review and Prospective Insight
Authors: Kumar Suneel , Kumar Varinder , Devi Nisha , Attri Kamlesh , Bhatt Isha Kumari
Published: December 2024

This study provides a comprehensive analysis of Small and Medium-sized Enterprises (SMEs) in the tourism and hospitality sectors, drawing insights from 111 publications across 81 journals. The bibliographic coupling analysis reveals nine thematic clusters, including resilience, competitiveness, innovation, marketing, financial dynamics, and crisis management strategies Additional research identifies key theoretical perspectives, including agency theory, Resource-Based View (RBV), Theory of Planned Behavior (TPB), and organizational change management, highlighting the complex interplay of financial, environmental, and social factors influencing SME operations. In India, SMEs, particularly in rural areas, face significant challenges related to finance, branding, and digitalisation. Despite these obstacles, they are of considerable economic importance, necessitating targeted government support and capacity-building initiatives for sustainable growth. These findings offer valuable insights for policymakers, researchers, and industry practitioners, emphasising the need for enhanced infrastructure and strategic interventions to foster competitiveness and long-term sustainability in tourism SMEs.
ESG Practices and Corporate Dividend Decision: A Moderated Mediating Analysis
Authors: Shah Avani , Shome Samik , Bhayani Sanjay
Published: December 2024

The study examines the direct and indirect roles of CEO efficiency and firm reputation respectively, in order to investigate the relationship between ESG practices and corporate dividend decisions of the Indian companies. The data is collected from NSE Nifty 500 and S&P BSE 500 index of the Indian listed firms during the period 2013 to 2022. The study also aims in addressing the drawbacks of the previous literature who assumes the direct relationships of the ESG disclosure on corporate dividend decisions which are inconclusive. Using the fixed effect model and structural equation model, the study demonstrates favourable and substantial correlations between ESG practices and dividend decisions that are conveyed through the corporate reputation. Further, through the application of the Instrument Variable Two Stage Least Square (2SLS IV) regression approach, CEO’s efficiency amplifies the insignificant impact of ESG disclosure on the company’s reputation. The results report that company reputation is a matter of stakeholders’ perceptions and reputation is distinct from the actual character and behaviour of the companies with the longitudinal data. The outcome of the study offers insights into how lack of consideration of factors results in inconsistent findings as reported in the previous literature.
Does Indian ADR Stocks Uncertainty Shock Play Important Roles in the Mobility of US Stock Market
Authors: Singh Amar , Gour Tanuja , Mohan Arvind
Published: December 2024

The study focuses on the selection of Indian ADR (American depository receipts) equities for the mobility of the US stock market, which are listed on the US stock exchange. This study evaluated the dynamic link between Indian ADR and the US stock market utilising VAR Granger Causality/Block Exogeneity Wald Tests, followed by variance decomposition and impulse response. The NYSE (New York Stock Exchange) is used as a proxy variable for the US stock market. The research gathered data with the goal of having a data range of twenty years. The data range of less than twenty years was excluded from the investigation, and the study was completed with seven Indian ADR variables out of fourteen Indian ADR variables. Daily time-series data for seven Indian ADR variables listed in the US market have been gathered from 2001 to 2021. The result verifies that NYSE is caused by WIT (Wipro Limited), HDB (HDFC Bank Limited), and SIFY (Sify Technologies Limited), and it confirms that NYSE is also causing RDY (Dr. Reddy’s Laboratories Limited) and SIFY, respectively. As a result, the bivariate causation between SIFY and NYSE is confirmed SIFY is the Indian ADR that is contributing to the NYSE’s mobility among all Indian ADRs listed on the foreign stock exchange. IBN (ICICI Bank Ltd.) and WIT are contributing to the variance decomposition of NYSE, and this is a highly significant variation in NYSE when compared to other variables. The SIFY’s asymmetric influence on the NYSE is represented by the impulse response function.
Meta-Analysis of the Impact of Debt Utilisation on Corporate Valuation: Unravelling Patterns Across Industries and Economic Conditions
Authors: Goel Shweta
Published: December 2024

Optimum composition of debt and equity is an important factor in assessing the valuation of the company. Companies often faced a problem in choosing the optimum amount of debt in their capital structure. This paper aimed at investigating the relationship between debt and earnings of the company using meta-analysis to ascertain what has been accounted in previous literatures. Using Forest Plot, Confidence Interval: Hypothesis Testing, Test of Heterogeneity and Publication Bias analysis and a sample of published journal articles, it is evident that the Value of business is independent of Debt usage and firms cannot increase the value of its business by increasing the level of Debt. However, an increase in debt-to-equity ratio beyond a certain level will negatively affect their businesses as it increases the level of risk in the business. Therefore, capital structure is not a good fit in explaining changes in the valuation of a company. While capital structure remains an important concern for businesses looking to improve their financial performance, our findings indicate that it may not be the only factor influencing changes in company valuation. In today’s changing economic world, educated decision-making and long-term business success require a comprehensive grasp of the intricate interplay between debt, profitability, and risk factors.
Evaluating SMEs Exchange as an Emerging Platform in India
Authors: Chouhan Vineet , Goswami Shubham
Published: December 2024

Stock exchanges are the cornerstones of every nation’s growth, and capital markets are the nation’s foundation too. Hence, the growth of the Stock Markets of the world is directly related to the production of the economy of every country. It can be noted from the last few years that the stock markets have expanded to suit the unmet needs. Stock market improvement has been created, and different products have been produced to meet the requirements. Commodities and the financial markets are the correct examples. The goal of this paper is to assess that the SME exchange provides companies with a new forum from which they can transfer to the exchange’s main board. Till 2022, 107 companies have been transferred from NSE Emerge to the NSE mainboard market. The research hypothesis of the paper is to measure the performance of the companies that migrated from the SME’s exchange to the main board of the NSE market. Using the independent sample t check with SPSS tools, we took a survey of 107 companies from the NSE Emerge that is being evaluated for their success before and after migration. This study’s added value is to measure that whether the migration is a mean of increasing the profitability of the migrated company or not. We used the statistical tool independent sample t test on pre- and post-migration return differences. Our analysis reveals that when a corporation opts for a main board (NSE) listing, its shares often generate a favourable anomalous return although it was not found significant for post-migration return capabilities.