bluuebunny/crossref_metadata_2025 huggingface dataset:
Meta-analysis in Sociological Research: Power and Heterogeneity
Authors: Tong Guangyu , Guo Guang
Published: November 2019

Meta-analysis is a statistical method that combines quantitative findings from previous studies. It has been increasingly used to obtain more credible results in a wide range of scientific fields. Combining the results of relevant studies allows researchers to leverage study similarities while modeling potential sources of between-study heterogeneity. This article provides a review of the core methodologies of meta-analysis that we consider most relevant to sociological research. After developing the foundation of the fixed- and random-effects models of meta-analysis models, this article illustrates the utility of the method with regression coefficients reported from two sets of social science studies. We explain the various steps of the process including constructing the meta-sample from primary studies, estimating the fixed- and random-effects models, analyzing the source of heterogeneity across studies, and assessing publication bias. We conclude with a discussion of steps that could be taken to strengthen the development of meta-analysis in sociological research, which will eventually increase the credibility of sociological inquiry via a knowledge-cumulative process.
Teaching Students About Sender and Receiver Variability in Lie Detection
Authors: Masip Jaume , Levine Timothy R. , Somastre Sandra , Herrero Carmen
Published: November 2019

Deception detection is a topic covered in many psychology and communication courses. We designed and implemented an engaging class activity to facilitate the students’ learning of several key concepts related to sender and receiver variability in lie detection. The pedagogical effectiveness of the activity was measured. In line with previous research, the students had difficulty acknowledging and correcting their own biases. However, the teaching activity was successful in correcting their general beliefs and facilitating learning.
Exploring Entrepreneurs' Perceptions of Venture Capitalists' Added Value
Authors: Vaidyanathan Rajiv , Vaidyanathan Vijay , Wadhwa Vivek
Published: November 2019

Recent research on the marketing-entrepreneurship interface has highlighted the importance of understanding the relationships between various actors that enable entrepreneurial activity. Entrepreneurs often depend on VCs not just for funding, but also for their expertise in environmental scanning, innovation, and strategic direction. This study takes the perspective of entrepreneurs as consumers of the value offered by VC firms and uses a broad survey of entrepreneurs to understand the factors that could affect long term relationships between these actors. The results show that entrepreneurs select VCs primarily on their perceptions of the fairness of the contract, reputation, and startup valuation. We also find evidence that entrepreneurs are uniformly disappointed in their experiences with VCs when comparing their pre- and post-financing views. Our findings contain important implications for a creating a balanced macromarketing view of the VC-entrepreneur relationship and holds practical implications for venture capitalists, entrepreneurs, and policy makers.
Experimental extrapolation of hardening curve for cylindrical specimens via pre-torsion tension tests
Authors: Chen Junfu , Guan Zhiping , Ma Pinkui , Li Zhigang , Gao Dan
Published: November 2019

The hardening curve for cylindrical specimens determined by conventional uniaxial tension tests generally corresponds to a relatively narrow strain range due to the occurrence of necking. To achieve the hardening curve within a large strain range, in this study, the multi-specimen tension tests with pre-torsion are developed through extrapolating the hardening curve from the stress–strain data of cylindrical specimens with various magnitudes of pre-torsion strains. The calculation of pre-strain of twisted specimen needs to be addressed for the multi-specimen tension tests. The three calculation methods on the multi-specimen tension tests are proposed, leading to their individual hardening curves for Q345 specimens. An optimal strategy for the multi-specimen tests with pre-torsion is presented by comparison with the inverse method for a single specimen tension test. The results for Q345 specimen show the strain range (0–0.6) of the hardening curve determined by the multi-specimen tension tests is significantly larger than one (0–0.04) from conventional tension test, with reasonable accuracy. Compared with the current multi-specimen tests with pre-extrusion/drawing, the proposed multi-specimen tests with pre-torsion is possessed of stronger applicability and generality, lower cost, and higher efficiency.
Dystopian literature and the sociological imagination
Authors: Seeger Sean , Davison-Vecchione Daniel
Published: November 2019

This article argues that sociologists have much to gain from a fuller engagement with dystopian literature. This is because (i) the speculation in dystopian literature tends to be more grounded in empirical social reality than in the case of utopian literature, and (ii) the literary conventions of the dystopia more readily illustrate the relationship between the inner life of the individual and the greater whole of social-historical reality. These conventional features mean dystopian literature is especially attuned to how historically-conditioned social forces shape the inner life and personal experience of the individual, and how acts of individuals can, in turn, shape the social structures in which they are situated. In other words, dystopian literature is a potent exercise of what C. Wright Mills famously termed ‘the sociological imagination’.
Research on the construction of the spiral evolutionary design methodology for a product service system based on existing products
Authors: Jiang Shaofei , Feng Di , Lu Chunfu , Li Jiquan , Chai Hao
Published: November 2019

A product service system composed of products, services, hardware and software support, and stakeholders enhances the added value and competitiveness of products through resource integration. To reduce the input in servitization and improve feasibility, manufacturers tend to construct a product service system based on existing products to meet the demands of customers, instead of constructing a completely new product service system. Therefore, this article presents a spiral evolutionary design method to construct a product service system based on existing products. With the ultimate goal of the system evolution being the maximization of the use of existing products while satisfying the demands of customers, the system performance will be spirally upgraded under the guidance of the system evolution chain through the operation of the system symbiotic ring. The construction of a mobile fire extinguishing product service system based on existing fire-fighting equipment was used as an example to illustrate the feasibility of this methodology. Finally, a feasibility evaluation system was established to evaluate and compare the previous product service system methodologies with the methodology in this article.
Green machining for the dry milling process of stainless steel 304
Authors: Nguyen Trung-Thanh , Mia Mozammel , Dang Xuan-Phuong , Le Chi-Hieu , Packianather Michael S
Published: November 2019

Dry machining represents an eco-friendly method that reduces the environmental impacts, saves energy costs, and protects operator health. This article presents a multi-response optimization which aims to enhance the power factor and decrease the energy consumption as well as the surface roughness for the dry machining of a stainless steel 304. The cutting speed ( V), depth of cut ( a), feed rate ( f), and nose radius ( r) were the processing conditions. The outputs of the optimization are the power factor, energy consumption, and surface roughness. The relationships between inputs and outputs were established using the radial basis function models. The experimental data were normalized, with the use of the Grey relational analysis. The principal component analysis is applied to calculate the weight values of technical responses. The desirability approach is used to observe the optimal values. The results showed that the technical outputs are primarily influenced by the feed rate and cutting speed. The reductions of energy consumption and surface roughness are approximately 34.85% and 57.65%, respectively, and the power factor improves around 28.83%, compared to the initial process parameter settings. The outcomes and findings of the investigated work can be used for further research in sustainable design and manufacturing as well as directly used in the knowledge-based and expert systems for dry milling applications in industrial practices.
Difference between the ideal and combined spherical joints and its effects on parallel manipulators
Authors: Fan Shuai , Fan Shouwen
Published: November 2019

When using parallel manipulators as machine tools, the spherical joint has been widely used and replaced by a combination of a universal joint and a rotating unit, but the introduced differences and effects have not been studied in detail. In this paper, an approach to establish the mathematical models of the ideal and combined spherical joints is presented, and the differences between the two spherical joints are given from the perspective of constraints, workspace, clearance, and contact deformation. First, the non-interference workspace of a class universal joint is investigated by using a simple and clear projection method, where the constraint domain and workspace of two spherical joints are proposed. Next, the approximate clearance models of these two spherical joints are analyzed, and the corresponding contact deformation models are also given based on the Hertzian Contact theory. Finally, a 1PU + 3UPS parallel manipulator is used to verify the discrepant effects of two spherical joints on parallel manipulators. If the combined spherical joint is used, the results indicate that the improvement in the workspace is significant, but the drop in stiffness is also evident. Thus, this paper provides a theoretical basis for researchers to use combined spherical joints.
Recommended method for health services to determine adherence to antiretroviral therapy: a comparison of three models
Authors: Costa Camila K , Abe Simone Y , da Silva Guilherme P , Carneiro Eliane , Miguel Marilis D
Published: November 2019

The medication possession ratio (MPR) method is commonly used for the determination of antiretroviral medication adherence. However, different ways of calculating MPR and methodological issues hinder the interpretation of the results and the reproducibility of the method. Thus, this study used three different models of MPR calculation and aimed to identify the one that best represents the situation of patient adherence. The results show that there was a statistically significant difference between the adherence rates determined by the three models, which indicates the need to specify the parameters used for calculation in the MPR method. However, the models individually were found to be related to viral suppression, but none of them had a greater effect than the other in this regard. The model that used residual medication (RM) and a fixed period of analysis allowed for a more precise identification of the number of doses that the patient used when compared to the others. Health services should avoid the application of the model using a variable analysis period. This study found that RM and the period of analysis considered are the main influencing factors in the accuracy of adherence results when the MPR method is used.
A review on the cardioprotective mechanisms of metformin against doxorubicin
Authors: Ajzashokouhi AH , Bostan HB , Jomezadeh V , Hayes AW , Karimi G
Published: November 2019

Doxorubicin (DOX) is an antineoplastic agent obtained from Streptomyces peucetius. It is utilized in treating different kinds of cancers, such as leukemia, lymphoma, and lung, and breast cancers. The main side effect of DOX is cardiotoxicity. Metformin (MET) is an antihyperglycemic drug used for type 2 diabetes treatment. It is proposed that MET has a protective effect against DOX cardiotoxicity. Our review demonstrated that MET has several possible mechanisms of action, which can prevent or at least reduce DOX cardiotoxicity including a decrease of free radical generation and oxidative stress, 5′ adenosine monophosphate-activated protein kinase activation, and ferritin heavy chain expression in cardiomyocytes cells. The combination of MET and DOX has been shown to enhance the anticancer activity of DOX by a number of authors. The literature reviewed in the present report supports the hypothesis that MET can reduce the cardiotoxicity that often occurs with DOX treatment.
The Nexus Between Obesity, Health and Social Care Needs for Older Adults: A Literature Review
Authors: Ghosh Gargi , Khan Hafiz T. A. , Thomas and Jane
Published: November 2019

This article aims to critically review the literature on the consequences of obesity among older adults and its association with health, well-being, and social care need. A search was conducted using, primarily, three databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL) Complete, Medical Literature Analysis and Retrieval System Online, or MEDLARS Online (MEDLINE) and Academic Search Elite with the help of Boolean operators. Inclusion and exclusion criteria were set to avoid bias in the selection of articles. Publications were reviewed to identify the impact of obesity among older people in terms of health and social care needs and to establish a relation between them. Gaps in the literature have been identified concerning obesity in the older adults, their health status, well-being, and social care need. The research questions were formulated to satisfy these gaps. A conceptual model was developed to map out the theoretical threads to form a diagrammatic representation to satisfy the research questions based on existing literature.The literature review established that the degree of disabilities and comorbidities related to obesity are directly proportionate and identified the gaps in the literature, where further research work is needed. The research objectives were built according to the identified gaps, the research questions were formulated to satisfy the research objectives, and a conceptual framework was also drawn to establish the links between the research questions. This review will guide a way forward to explore the unmet care needs of the aging society.
Pharmacotherapeutic Management Strategies for Thyroid Disease–Induced Pericarditis
Authors: Schwier Nicholas C. , O’Neal Katherine
Published: November 2019

Objective: To describe the various pharmacotherapeutic strategies in managing thyroid disease-induced pericarditis (TDIP). Considerations for both hypothyroid-induced and hyperthyroid-induced pericarditis will be discussed. Data Sources: A literature search of MEDLINE, including PubMed, was performed inclusive of all years, using the following search terms: thyroid disease, pericardial diseases, pericarditis, acute pericarditis, cholesterol pericarditis, hypothyroidism, hyperthyroidism, colchicine, corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, methimazole, propylthiouracil, and P-glycoprotein. Product monographs were reviewed as well. Study Selection and Data Extraction: Relevant English-language studies and data as well as the most current guidelines for diagnosis and management of thyroid and pericardial diseases were considered. Because of limited data regarding the subject matter, no date range limits were established during literature search. Data Synthesis: It is well documented that thyroid dysfunction can adversely affect cardiovascular function. Additionally, there are published guidelines on the diagnosis and management of pericarditis and, separately, thyroid disease. There are limited data, however, on managing TDIP. The sequela of untreated TDIP can be detrimental. Relevance to Patient Care and Clinical Practice: Strategies on managing TDIP are scarcely reported in the literature. This review provides clinicians with a single reference source for treatment strategies toward managing hypothyroidism-induced and hyperthyroidism-induced pericarditis as well as significant drug interactions that can potentially confound the management of hypothyroidism- and hyperthyroidism-induced pericarditis. Conclusions: Treatment of TDIP involves addressing both the thyroid disease as well as the pericarditis. Along with treatment strategies, clinicians should also consider potential drug-drug and drug-disease interactions that can potentially worsen clinical outcomes.
Repeatability and reproducibility of corneal biomechanical parameters derived from Corvis ST
Authors: Serbecic Nermin , Beutelspacher Sven , Markovic Lovro , Roy Abhijit Sina , Shetty Rohit
Published: November 2019

Introduction:

The aim of this study was to evaluate repeatability and reproducibility of newly calculated biomechanical parameters of the cornea, developed by our research group.

Methods:

One eye from each of the 23 healthy subjects was measured three times consecutively, three times at different daytimes and on three different days. The within-subject standard deviation and coefficient of variation, as well as the intraclass correlation coefficient, were calculated for every parameter in each group.

Results:

Excellent repeatability and reproducibility (coefficient of variation < 5%, intraclass correlation coefficient > 0.75) was found for corrected values measured at A1, HC, and A2 time points (2nd A2 Time, 2nd A1 Time, 2nd HC Time, 2nd HC Def Amp and 2nd A1 Def Amp). Corneal-specific stiffness parameters, which showed good repeatability and reliability, were DA_cor (coefficient of variation = 4.02%, intraclass correlation coefficient = 0.919), KcLinear (coefficient of variation = 4.03%, intraclass correlation coefficient = 0.895), areaForceCornea (coefficient of variation = 3.34%, intraclass correlation coefficient = 0.853) and E2 (coefficient of variation = 4.1%, intraclass correlation coefficient = 0.78). Overall, most parameters fell into the category of good reliability (high intraclass correlation coefficient) and poor reproducibility (low coefficient of variation), including all the parameters describing extraocular deformation (DA_ext, AEPvED, AUC EDef, areaForceExtra, Kg and μg). Comparing the coefficient of variation values for intrasession, intersession and daytime measurements, there were no indices for diurnal changes.

Conclusion:

Most parameters showed good repeatability and reliability. The extraocular stiffness parameters showed poor reproducibility. KcLinear can serve as a very reliable and repeatable indicator of corneal stiffness.
Paracentral acute middle maculopathy associated with hypoperfusion of the cilioretinal artery and impending central retinal vein occlusion
Authors: da Fonseca Maria Luisa Gois , Souza Amanda , Pereira Mauricio Bastos , Vianna Raul Nunes Galvarro , Cravo Leonardo Midleg , Demori Erika
Published: November 2019

Background:

Paracentral acute middle maculopathy is defined as ischemia of the deep retinal layers. We report an unusual case of paracentral acute middle maculopathy associated with hypoperfusion of the cilioretinal artery and impending central retinal vein occlusion in a young male with no previous comorbidities.

Case Report:

The patient was a 22-year-old male complaining about a sudden loss of vision in his right eye upon awakening. Fundus examination showed optic disk edema, and increased tortuosity of the retinal veins and a few retinal hemorrhages. Swept-source optical coherence tomography found a hyperreflective band that was more pronounced at the level of the inner nuclear layer of the retina. These findings led us to a diagnosis of paracentral acute middle maculopathy associated with hypoperfusion of the cilioretinal artery.

Conclusion:

The finding of paracentral acute middle maculopathy on optical coherence tomography demands a proper investigation of its cause, because it has an intimate association with vascular diseases and is not an isolated entity. In our case, we could not identify the etiology of the unilateral event in this young male, although dehydration due to alcohol consumption and subsequent hypotension might have played a role in this ischemic event.
Students' landscaping preferences for open spaces for their campus environment
Authors: Hami Ahmad , Abdi Babak
Published: November 2019

This study seeks to find appropriate landscape patterns of campus based on students’ preferences. A photo questionnaire containing scenes of different types of campus landscapes was distributed among 200 students in University of Tabriz, Iran. The results emphasized the importance of vegetation, seating areas and water features of campuses. Also, students prefer open spaces consisting of lawn and grass (M = 3.31, S.D. = 1.00). Students also prefer a campus, which has a natural base, landscape elements and seating places, while the least preferred (M = 2.96, S.D. = 0.89) scenes comprise a large amount of hardscape. Students had a different preference for landscaping of open study area and leisure time place where the studying area should be designed with vertical natural elements. Shading trees and benches were also highlighted as very important furniture for these places. In terms of spatial organization, the content analysis revealed that these areas should be open and spacious. Places for leisure time need to be decorated with informal landscape design for creating a pleasant view. Designing a landscape with various forms will make these places more pleasant. Scenes of curved paths and colourful plants for these places showed a positive association with student socialization activities.
From food to feet: Analysing A Bite of China as food-based destination image
Authors: Xu Min , Kim Sangkyun , Reijnders Stijn
Published: November 2019

This article discusses the reception of the highly popular documentary television series A Bite of China among potential young domestic travellers. It aims to investigate how this series, and similar food- and culture-themed TV programmes, contributes to regional food-based destination images among the aforementioned class of travellers. The analysis of 15 semi-structured interviews with viewers suggests that the documentary can influence and change viewers’ perceptions of regional cuisine as well as local culture. Viewers engage in both cinematic and touristic consumption as they interpret the documentary. Credible food images aid the process of building perceptual images that distinguish a destination from other destinations, which in some cases also inspires viewers to actually visit the related destinations or locations. More particularly, this exploratory study shows how these travellers perceive food-based destination images not as an isolated phenomenon, but as an integral part of a broader place-identity.
Patient-reported outcomes at hospital discharge among patients with arrhythmia: Results from the national DenHeart survey
Authors: Thrysoee Lars , Thorup Charlotte Brun , Rasmussen Trine Bernholdt , Borregaard Britt , Christensen Anne Vinggaard , Juel Knud , Ekholm Ola , Vamosi Marianne , Banke Ann , Berg Selina Kikkenborg
Published: November 2019

Background:

Patient-reported outcomes are important predictors of mortality, cardiovascular events and hospitalisation in patients with cardiac diseases, but differences in patient-reported outcomes between groups of patients with arrhythmia have not yet been investigated.

Aims:

To describe and compare patient-reported outcomes at discharge among patients with different types of cardiac arrhythmia and to examine the associations between demographic characteristics, inhospital factors and patient-reported outcomes.

Methods:

Data were derived from the national DenHeart study including patient-reported outcomes from the following questionnaires: the hospital anxiety and depression scale (HADS), HeartQoL, short form 12 (SF-12), current health status (EQ-5D), brief illness perception questionnaire (B-IPQ) and the Edmonton symptom assessment scale (ESAS). Clinical and demographic data were obtained from national registers. Multiple linear and logistic regression models were used to investigate the associations between the potential risk factors and the patient-reported outcomes.

Results:

A total of 4251 patients diagnosed with arrhythmia completed the questionnaire. Across the arrhythmia subgroups, some differences were observed. In general, patient-reported outcome scores were worst among patients with ‘ventricular arrhythmia’ (e.g. highest depression scores and highest prevalence of feeling unsafe at discharge). Regression analysis revealed that longer hospital stay, female gender, being unmarried and having a short education were significantly associated with poor health for almost all arrhythmia subgroups.

Conclusion:

Differences exist in self-reported health, quality of life and symptom burden across arrhythmia groups with patients with ventricular arrhythmia reporting poorer patient-reported outcomes. Longer hospital stay, female gender, being unmarried and having a low level of education were significantly associated with worse outcomes among the total population.
Group-Delivered Enhanced Cognitive Behavior Therapy: A Focus on a Young Adult Woman With Bulimia Nervosa
Authors: Hambleton Ashlea L. , Hanstock Tanya L. , Simeone Rachel , Sperling Michelle
Published: November 2019

Enhanced Cognitive Behavioral Therapy (CBT-E) is an evidence-based treatment for bulimia nervosa (BN), which can be delivered individually or in a group format. This case study describes a young adult female’s progress through a CBT-E group program at an Australian community outpatient eating disorder service. She completed 20 sessions over 10 weeks. The client was administered measures for eating disorder symptoms, depression, anxiety, stress, stage of change, and clinical impairment at pre- and posttreatment. She improved on global eating disorder symptoms, food restriction, eating concern, and her stage of change. Her weight and shape concerns remained unchanged. Her levels of depression, anxiety, and stress significantly increased after treatment, highlighting the need for concurrent treatment for these comorbidities. These results support the developing literature on the efficacy of CBT-E for BN and describe in detail the progress of an individual, including their progress and challenges within a group intervention.
Preprocedural Cross-Sectional Imaging Prior to Percutaneous Peripheral Arterial Disease Interventions
Authors: Itoga Nathan K. , Ho Vy T. , Tran Kenneth , Chandra Venita , Dalman Ronald L. , Harris Edmund J. , Lee Jason T. , Mell Matthew W.
Published: November 2019

Preprocedural cross-sectional imaging (PCSI) for peripheral artery disease (PAD) may vary due to patient complexity, anatomical disease burden, and physician preference. The objective of this study was to determine the utility of PCSI prior to percutaneous vascular interventions (PVIs) for PAD. Patients receiving first time lower extremity angiograms from 2013 to 2015 at a single institution were evaluated for PCSI performed within 180 days, defined as computed tomography angiography (CTA) or magnetic resonance angiography (MRA) evaluating abdominal to pedal vasculature. The primary outcome was technical success defined as improving the target outflow vessels to <30% stenosis. Of the 346 patients who underwent lower extremity angiograms, 158 (45.7%) patients had PCSI, including 150 patients had CTA and 8 patients had MRA. Of these, 48% were ordered by the referring provider (84% at an outside institution). Preprocedural cross-sectional imaging was performed at a median of 26 days (interquartile range: 9-53) prior to the procedure. The analysis of the institution’s 5 vascular surgeons identified PCSI rates ranging from 31% to 70%. On multivariate analysis, chronic kidney disease (odds ratio [OR] = 0.35; 95% confidence interval [CI]: 0.17-0.73) was associated with less PSCI usage, and inpatient/emergency department evaluation (OR = 3.20; 95% CI: 1.58-6.50) and aortoiliac disease (OR = 2.78; 95% CI: 1.46-5.29) were associated with higher usage. After excluding 31 diagnostic procedures, technical success was not statistically significant with PSCI (91.3%) compared to without PCSI (85.6%), P = .11. When analyzing 89 femoral–popliteal occlusions, technical success was higher with PCSI (88%) compared to procedures without (69%) P = .026. Our analysis demonstrates that routine ordering of PCSI may not be warranted when considering technical success of PVI; however, PCSI may be helpful in treatment planning. Further studies are needed to confirm these findings in another practice setting, with more prescriptive use of PCSI to improve procedural success, and thereby improve the value of PCSI.
Medication management in intellectual disability settings: A systematic review
Authors: Sheerin Fintan , Eustace-Cook Jessica , Wuytack Francesca , Doyle Carmel
Published: November 2019

There is a high level of medication usage among people with intellectual disability due to the presence of significant morbidity and co-morbidities. This review sought to explore medication management and administration in intellectual disability settings, identifying frameworks for practice, analysing whether collaborative practice led to better outcomes, identifying key processes associated with practice, locating tools to support practice and describing metrics for outcome measurement. A systematic review was conducted with analysis of 64 sources which remained following screening and appraisal. Limited evidence was identified with some insight into the processes underpinning medication management and administration. No assessment tools were found, but two potential outcome measures, adherence and errors, were noted. The paucity of guidelines and frameworks is concerning as this is a complex area of practice. There is a need for further practice development and research to be undertaken that takes note of the unique issues that can present in intellectual disability settings.
A Psychological Profile of the Alt-Right
Authors: Forscher Patrick S. , Kteily Nour S.
Published: November 2019

The 2016 U.S. presidential election coincided with the rise of the “alternative right,” or alt-right. Alt-right associates have wielded considerable influence on the current administration and on social discourse, but the movement’s loose organizational structure has led to disparate portrayals of its members’ psychology and made it difficult to decipher its aims and reach. To systematically explore the alt-right’s psychology, we recruited two U.S. samples: An exploratory sample through Amazon’s Mechanical Turk ( N = 827, alt-right n = 447) and a larger, nationally representative sample through the National Opinion Research Center’s Amerispeak panel ( N = 1,283, alt-right n = 71–160, depending on the definition). We estimate that 6% of the U.S. population and 10% of Trump voters identify as alt-right. Alt-right adherents reported a psychological profile more reflective of the desire for group-based dominance than economic anxiety. Although both the alt-right and non-alt-right Trump voters differed substantially from non-alt-right, non-Trump voters, the alt-right and Trump voters were quite similar, differing mainly in the alt-right’s especially high enthusiasm for Trump, suspicion of mainstream media, trust in alternative media, and desire for collective action on behalf of Whites. We argue for renewed consideration of overt forms of bias in contemporary intergroup research.
Examining the Relationship Between Teacher Perceptions of Implementation of the SDLMI and Student Self-Determination Outcomes
Authors: Shogren Karrie A. , Burke Kathryn M. , Anderson Mark H. , Antosh Anthony , LaPlante Terri , Hicks Tyler
Published: November 2019

This study explored teacher perceptions of their ability to implement the Self-Determined Learning Model of Instruction (SDLMI) with fidelity and the impact of these perceptions on student self-determination outcomes on the Self-Determination Inventory: Student Report (SDI:SR). Using a piece-wise growth model, we found stability in teacher perceptions of their implementation over a 2-year period even with the introduction of a second transition-focused intervention to a subset of the sample. Using a mediation model, we then found a complex relationship between teacher perceptions of fidelity and student outcomes on the SDI:SR. We found that teacher-perceived fidelity over the course of the year was influenced by students’ beginning of the year self-determination status and that teacher-perceived fidelity then affected students’ end of the year self-determination status. The findings suggest an interactive relationship between teacher perceptions of implementation and student outcomes. Implications for research and practice are discussed.
Utility of Daily Laboratories in Patients with Lymphoma Admitted for Inpatient Chemotherapy
Authors: Anscher Daniel , El-Far Ahmad , Baidas Said M
Published: November 2019

Background: Daily CBC (Complete blood count) and CMP (Complete metabolic profile) have been drawn on our patients with high-grade lymphoma admitted for inpatient chemotherapy with R-EPOCH (Rituximab, Prednisone, Vincristine, Cyclophosphamide, Doxorubicin) which is given over 5 days and R-ICE (Rituximab, Ifosfamide, Carboplatin, Etoposide) which is given over 3 day period. We conducted a retrospective study at our center looking to find if daily laboratory, other than day 1 laboratory, will have an impact on decisions regarding 1) change in chemotherapy dose or schedule 2) requirement of Blood products transfusion 3) cost effectiveness.

Methods: We did retrospective review of 101 admissions between 2010-2017. We documented how frequent CBC and CMP were obtained during patient admissions. We documented any change in chemotherapy schedule or dose, or any need for blood product transfusion based on results of laboratory obtained starting day 2 of cycle 2. We excluded day 1 given that its results are required to proceed with chemotherapy. Also we excluded induction cycle 1. We documented cost of laboratory obtained other than day 1.

Results: Daily CBC and CMP did not lead to any significant changes in plan of care of chemotherapy regimen and only lead to blood transfusions in 4.1% of patients on R-EPOCH and 6% of patients on R-ICE regimens. The cost associated with daily CBC and CMP was $1725 for R-EPOCH regimen and $1339 for R-ICE regimen.

Conclusion: We recommend only day 1 CBC/CMP for patients admitted for R-EPOCH and R-ICE chemotherapy starting cycle 2. Daily CBC/CMP didn't lead to any significant changes on the plan of care and added more cost.

Table

Disclosures

No relevant conflicts of interest to declare.
Parents' Views on Preimplantation Genetic Testing for Sickle Cell Disease after Education in Clinic
Authors: Kripalani Shawn , Attia Monica , Darbari Isha , Nickel Robert Sheppard
Published: November 2019

Background: Preimplantation genetic testing (PGT) used in conjunction with in-vitro fertilization can help parents of a child with sickle cell disease (SCD) have another child who will not have SCD and also be an HLA match. Parents' views on this reproductive option are not well known and little work has been done regarding educating parents about this option. This study sought to describe parents' opinions on PGT after a clinic-based educational intervention.

Methods: A 5-page educational handbook was created on PGT for SCD. During certain clinic days, all parents of children with SCD were given this handbook in the waiting room and encouraged to read it and ask their provider questions during their clinic visit. After this visit, parents were then requested to complete a brief, anonymous survey via REDCap. Non-biological parents and other guardians were excluded. An IRB waiver of consent was granted as no personal health information was collected.

Results: Between May and July 2019, 83 biologic parents of children with SCD were approached in the clinic and 67 (81%) of these parents completed the questionnaire. This group had a median age of 34 years and included 52 mothers and 15 fathers. While 53 (79%) indicated that they had previously heard of bone marrow transplant for SCD before today, only 16 (24%) answered that they had heard of PGT for SCD (p<0.0001). When asked about their opinion on informing parents of SCD about PGT: 45 (67%) stated this information was "very important," 20 (30%) "important," 1 (2%) "a little important," and 1 (2%) "not important." The majority (69%) of parents indicated that education on PGT should occur "at the very first hematology clinic visit." Only 9 (13%) parents responded that they could pay $20,000 for PGT, while 65 (97%) answered that they think it should be covered by health insurance. Among parents who indicated that they might want to have more children (n=32), 29 (91%) answered that they would be interested in using PGT if covered by insurance.

Conclusion: Most parents of children with SCD seen in the hematology clinic do not know about PGT, but when educated about this option, viewed this knowledge as important. Routine hematology clinic appointments in early childhood may be opportune times to educate patients about PGT. Cost may be a major barrier, but providers should discuss PGT with parents of children with SCD to help ensure access to this option.

Disclosures

No relevant conflicts of interest to declare.
Wdr26 regulates nuclear condensation in developing erythroblasts
Authors: Zhen Ru , Moo Chingyee , Zhao Zhenzhen , Chen Mengying , Feng He , Zheng Xiaojun , Zhang Liang , Shi Jiahai , Chen Caiyong
Published: November 2019

Mammalian red blood cells lack nuclei. The molecular mechanisms underlying erythroblast nuclear condensation and enucleation, however, remain poorly understood. Here we show that Wdr26, a gene upregulated during terminal erythropoiesis, plays an essential role in regulating nuclear condensation in differentiating erythroblasts. Loss of Wdr26 induces anemia in zebrafish and enucleation defects in mouse erythroblasts because of impaired erythroblast nuclear condensation. As part of the glucose-induced degradation-deficient ubiquitin ligase complex, Wdr26 regulates the ubiquitination and degradation of nuclear proteins, including lamin B. Failure of lamin B degradation blocks nuclear opening formation leading to impaired clearance of nuclear proteins and delayed nuclear condensation. Collectively, our study reveals an unprecedented role of an E3 ubiquitin ligase in regulating nuclear condensation and enucleation during terminal erythropoiesis. Our results provide mechanistic insights into nuclear protein homeostasis and vertebrate red blood cell development.
Improvement in Follicular Non Hodgkin Lymphoma Survival among VA Patients.
Authors: Desai Shaili , Safa Malek M. , Komrokji Rami S.
Published: November 2019

Background: Follicular non Hodgkin lymphoma (FL) remains uncurable disease for majority of patients. Natural history of follicular lymphoma is changing with inroduction of new treatments. We examined outcome of FL among VA patients in the era of monoclonal antibodies.

Methods: This was a retrospective analysis. The VA Central Cancer Registry (VACCR) database was used to identify patients with FL diagnosed between 1995 and 2005. There are approximately 120 VA medical centers diagnosing and/or treating patients with cancer. Data were analyzed using bio-statistical software SPSS. Variables included age, sex, stage of disease, histology subtype, date of diagnosis, date of last contact, vital status.

Results: There were1338 patients with FL at the VACCR database between 1995 and 2005, 283 (88%) were white, 128 (10%) black patients, and 39 (2%) patients from other racial groups. The mean age at diagnosis was to 64 years. Four hundred twelve (31%) were grade I FL, 312 (23%) Grade II, 215 (16%) Grade III, and 399 (30%) FL, NOS. Four hundred twelve (30%) patients were early stage (I,II), 600 (45%) were advanced stage (III,IV) and 331 (25%) missing or unkown. No FLIPI score data were available. Median overall survival (OS) was 7 years. The median OS for early stage was 8.6 years compared to 5.5 years for advanced stage. The median OS for patients diagnosed 1995–2000 was 5.9 years compared to 9.7 years for patients diagnosed between 2001–2005. (log rank test, P value 0.025). The two groups were balanced regarding stage, race and chemotherapy.

Conclusions: The survival of FL patients has improved in the VA system in the era of rituximab.

Figure Figure
Motexafin Gadolinium (MGD) Induces Oxidant Stress and Downregulates Both Pro and Anti-Oxidant Genes in the Ramos Lymphoma Cell Line: Signaling through p53 Mediated Pathways.
Authors: Singh Amareshwar T.K. , Evens Andrew M. , Haque Qudsia , Prachand Sheila N. , Singh Karthik T.K. , Gordon Leo I.
Published: November 2019

We have reported that MGd, an expanded porphyrin and redox stress inducer, lowers p53 protein but not message in lymphoma cell lines. These results suggested that there is post-translational modification of p53 induced by MGd, and that this effect depends on the presence of ascorbate (Asc) or zinc (Zn). To expand these earlier studies, we measured the expression of oxidant and antioxidant genes in Ramos (Burkitt’s) cells. We incubated Ramos cells for 5 hours with MGd 100μM with or without Zn acetate (Zn, 100μM), Asc 100μM, and Nutlin-3 15μM. Following incubation, total RNA was isolated by the Qiagen method and dissolved in RNase-free water. 1.0 μg RNA was used for reverse transcription using the Taq DNA polymerase system. PCR amplification was performed at 94°C for 30 sec (denaturation), 55°C (annealing) and 72°C (extension) for 35 cycles. This was followed by an extension at 72°C for 10 minutes. Anti-sense primers and sense primers for SESN1(T2), SESN2, GPX1, CDKN1A, and PP1A were used and DNA was identified by 1% agarose gel electrophoresis. The T2 transcript of SESN1 gene was absent in these cells. Co-treatment of MGd/Zn/Asc notably decreased GPX1, SESN2, and CDKN1A transcripts. To determine the role of p53 in the regulation of downstream redox targets, we added the MDM2 inhibitor, Nutlin-3. We found that GPX1, SESN2, and CDKN1A were restored with Nutlin-3. In addition, we measured another downstream target of p53, PUMA, in both Ramos and HF-1 cells (a follicular lymphoma cell line) by immunoblot after MGd, Zn, and Asc exposure in the presence or absence of Nutlin-3. PUMAα and PUMAβ isoforms returned to near baseline levels in the presence of Nutlin-3. The restoration of PUMA was more pronounced in HF-1 cells than in Ramos. In summary, then, we have shown that:

the MDM2 inhibitor, Nutlin-3 reversed the downregulation of SESN2, GPX1, and CDKN1A genes that occurred as a result of MGd/Zn/Asc in Ramos cells and similarly, PUMAα and β isoforms were restored with Nutlin-3 after decreased expression following exposure to MGd, zinc, and ascorbate.

These data indicate that some MGd-mediated signaling events in lymphoma cells are mediated through p53-dependent pathways.
Reduced Dose of Non-Pegylated Liposomal Doxorrubicin with Cyclophosphamide, Vincristine and Prednisone ± Rituximab for Elderly Patients with Aggressive Lymphoma Non Candidates to Standard Chemotherapy.
Authors: Gimeno Eva , Alvarez Alberto , Pedro Carme , Abella Eugenia , Gomez Miquel , Comin Josep , Besses Carles , Salar Antonio
Published: November 2019

BACKGROUND: CHOP± Rituximab regimen is the standard regimen for elderly patients with aggressive lymphoma. However, many of these patients present formal contraindication for this type of treatment due to severe associated comorbidities. The aim of the study is to retrospectively evaluate the safety and clinical profile of a modified CHOP (with low dose non-pegylated liposomal doxorrubicin) ± Rituximab in elderly patients with clinically aggressive lymphoma which are not tributary to standard chemotherapy.

PATIENTS AND METHODS. Retrospective analysis of 15 consecutively patients (pts) with previously untreated aggressive lymphoma. Gender: 9 men/6 women; median age: 76 years (62–85y). 6 pts had stage I–II (IPI=1–2) and 9 pts stage IV (IPI=2–5). Median baseline left ventricular ejection fraction (LVEF) was 60.2% (31–80%). Comorbidities: active chronic liver disease (1 pt), severe chronic obstructive pulmonary disease (3 pts), severe cardiomiopathy (4 pts) and others (7 pts). Schedule: non pegylated liposomal doxorubicin 30 mg/m2, cyclophosphamide 750 mg/m2, vincristine 1.4 mg/m2, prednisone 100 mg/d d1-5 ± rituximab 375mg/m2 d1) every 21 days, as a first line therapy. Pegfilgrastim was used on day 2 at standard dose.

RESULTS. Nine pts are evaluable for efficacy at the time of this report (2 pts died early due to infectious complications and are not evaluable for response). Median number of cycles was 4 (range 4–6). Total number of cycles administered was 43. A complete response (CR) was achieved in 8 pts (88.8%) and partial response in 1 pt (11.1%) after chemotherapy. CR was achieved in this last patient after involved field radiotherapy. Two pts have relapsed during follow-up, all dying with active disease. OS at 12 months: 70% (CI95%: 42–98%) and PFS at 12 months: 60% (CI95%: 30–90%), with a median time of follow-up for surviving pts of 18 months (4–35 m). Treatment was well tolerated with grade III–IV neutropenia was 39.5% with 14% episodes of febrile neutropenia. No other relevant toxicities were observed. Of note, median LVEF was not significantly different between before and after treatment with one patient showing a clinical significant improve in his LVEF.

CONCLUSION. This preliminary data indicate that low dose non-pegylated liposomal doxorubicin in modified CHOP regimen was active and well tolerated in patients with formal contraindications to standard therapy due to severe comorbidities. Further exploration of this regimen administered every 14 days is warranted.