bluuebunny/crossref_metadata_2025 huggingface dataset:
Left Ventricular Twist Mechanics Before and After Aortic Valve Replacement: A Feasibility Study and Exploratory Analysis
Authors: Zhang Kan , Kumar Nikhil , Alfirevic Andrej , Sale Shiva , You Jing , Bauer Andrew , Duncan Andra E.
Published: July 2022

Introduction. We examined whether intraoperative assessment of left ventricular (LV) twist mechanics is feasible with transesophageal echocardiography (TEE). We then explored whether twist mechanics were altered by hemodynamic conditions or patient comorbidities. Methods. In this sub-analysis of clinical trial data, transgastric short-axis echocardiographic images of the LV base and apex were collected in patients having aortic valve replacement (AVR) at baseline and end of surgery. Transvalvular gradients and LV systolic and diastolic function were assessed using two-dimensional (2D) and Doppler echocardiography. 2D speckle-tracking echocardiography was used for off-line analysis of LV twist, twisting rate, and untwisting rate. We examined the intraoperative change in twist mechanics before and after AVR. LV twist mechanics were also explored by diabetic status, need for coronary artery bypass grafting (CABG), and use of epinephrine/norepinephrine. Results. Of 40 patients, 16 patients had acceptable TEE images for off-line LV twist analysis. Baseline median [Q1, Q3] LV twist was 12 [7, 16]°, twisting rate was 72 [41, 97]°/sec, and untwisting rate was −91 [−154, −56]°/s. Median [Q1, Q3] change in LV twist at end of surgery was −2 [−5, 3]°, twisting rate was 7 [−33, 31]°/s, and untwisting rate was 0 [−11, 43]°/s. No difference was noted between diabetic and non-diabetic patients or AVR and AVR-CABG patients. Conclusion. LV twist was augmented in patients with aortic stenosis, though twist indices were not affected by reduced afterload, diabetes, or coronary artery disease. Intraoperative assessment of twist mechanics may provide unique information on LV systolic and diastolic function, though fewer than 50% of TEE examinations successfully assessed twist. Clinical Trial Registry. This work is a sub-analysis of a clinical trial, registered on ClinicalTrials.gov on August 19, 2010 (NCT01187329), Andra Duncan, Principal Investigator.
Assessment of the Carcinogenic Potential of Pretomanid in Transgenic Tg.rasH2 Mice
Authors: Ambroso Jeffrey L. , Dillberger John , Bruning-Barry Rebecca , Yang Tian
Published: July 2022

Pretomanid is a nitroimidazooxazine antimycobacterial drug that was approved as part of a three-drug oral regimen, consisting of bedaquiline, pretomanid, and linezolid, for 6-months treatment of adults with pulmonary extensively drug-resistant tuberculosis or with complicated forms of multidrug-resistant tuberculosis by the food and drug administration in the United States and regulatory bodies in over 10 other countries. Nitroaromatic compounds as a class carry a risk of genotoxicity and potential carcinogenicity based on reactive metabolite formation. A battery of good laboratory practice genotoxicity studies on pretomanid indicated that the compound was not genotoxic, however its hydroxy imidazole metabolite (M50) was genotoxic in the Ames assay. To assess the in vivo carcinogenic potential of pretomanid, hemizygous Tg.rasH2 mice were administered pretomanid once daily by oral gavage for 26 weeks. Male mice were given pretomanid in vehicle at doses of 0, 5, 15 and 40 mg/kg/day and female mice were given pretomanid in vehicle at doses of 0, 10, 30 and 80 mg/kg/day. Positive control mice of both sexes received intraperitoneal injections of urethane at 1000 mg/kg on Days 1, 3 and 5. There were no pretomanid-related early deaths, tumors, non-neoplastic microscopic findings, or gross necropsy findings at any dose level. The positive control gave the anticipated response of lung tumors. Oral administration of pretomanid to mice produced plasma exposure to the parent compound (high dose AUC of pretomanid 3 times the clinical AUC at the maximum recommended human dose) and exposure to the M50 metabolite (less than 10% of pretomanid) at all dose levels in both sexes. These data show that pretomanid was not carcinogenic in a transgenic mouse model at systemic exposures greater than human therapeutic exposures.
Gastroduodenal ulceration detected endoscopically in cats: retrospective study of 61 patients
Authors: Bottero Enrico , Pierini Alessio , Ruggiero Pietro , Cattaneo Deborah , Campanile Andrea , Benvenuti Elena
Published: July 2022

Objectives

The aim of this study was to describe the endoscopic appearance of gastroduodenal ulcers (GDUs), and to assess the clinical, ultrasonographic and histological data, as well as long-term follow-up, in cats.

Methods

The medical record databases of five veterinary endoscopists were evaluated between January 2016 and 2020, in a retrospective study. Cats with at least one gastric or duodenal ulcer detected by endoscopic examination were included. All the medical records of the selected cats were reviewed and information was collected regarding breed, age, sex, neuter status, medical history, clinical signs, and ultrasonographic, endoscopic and histological findings. The cats were evaluated at 6, 12 and 18 months.

Results

Sixty-one cats with a median age of 9.0 years (range 2.0–16.0) were included in the study. The most common complaints were vomiting (n = 55; 90%) and hyporexia (n = 40; 66%); haematemesis was reported in 12 (20%) cats. Endoscopy showed GDUs in the following locations: gastric body in 28 cats (46%), antropyloric area in 34 cats (56%), fundus in 13 cats (21%) and duodenum in eight cats (13%). A single GDU was found in 42 cats (69%) and multiple GDUs were seen in 19 cats (31%). Histopathological evaluation revealed benign lesions in 33 (54%) cats and malignant lesions in 28 (46%; 24 high-grade lymphoma, one low-grade lymphoma and three carcinoma). High-grade lymphoma was detected only in the stomach. Cats diagnosed with malignant GDUs (median 10.5, range 4–16) were significantly older than cats with benign lesions ( P = 0.002).

Conclusions and relevance

GDUs are common and were detected in 5.1% of cats undergoing an upper gastrointestinal endoscopy. The risk of a malignant ulcer increases proportionally with each year of increasing age. GDU location, number and morphological appearance do not provide any indication of the nature of the ulcer; however, duodenal ulcers are frequently benign. Endoscopic examination facilitates the early and minimally invasive detection of GDUs in cats.
Causes and predictors of failed same-day home discharge following primary hip and knee total joint arthroplasty: a Canadian perspective
Authors: Gazendam Aaron M , Tushinski Daniel , Patel Mansi , Bali Kamal , Petruccelli Danielle , Winemaker Mitchell , DeBeer Justin , Gillies Leslie , Best Katie , Fife Jennifer , Wood Thomas J
Published: July 2022

Purpose:

Same-day home (SDH) discharge in total joint arthroplasty (TJA) has increased in popularity in recent years. The objective of this study was to evaluate the causes and predictors of failed discharges in planned SDH patients.

Methods:

A consecutive cohort of patients who underwent total knee (TKA) or total hip arthroplasty (THA) that were scheduled for SDH discharge between 01 April 2019 and 31 March 2021 were retrospectively reviewed. Patient demographics, causes of failed discharge, perioperative variables, 30-day readmissions and 6-month reoperation rates were collected. Multivariate regression analysis was undertaken to identify independent predictors of failed discharge.

Results:

The cohort consisted of 527 consecutive patients. 101 (19%) patients failed SDH discharge. The leading causes were postoperative hypotension (20%) and patients who were ineligible for the SDH pathway (19%). 2 individual surgeons, later operative start time (OR 1.3; 95% CI, 1.15–1.55; p = 0.001), ASA class IV (OR 3.4; 95% CI, 1.4–8.2; p = 0.006) and undergoing a THA (OR 2.0; 95% CI, 1.2–3.1, p = 0.004) were independent predictors of failed SDH discharge. No differences in age, BMI, gender, surgical approach or type of anaesthetic were found ( p  > 0.05). The 30-day readmission or 6-month reoperation were similar between groups ( p  > 0.05).

Conclusions:

Hypotension and inappropriate patient selection were the leading causes of failed SDH discharge. Significant variability existed between individual surgeons failed discharge rates. Patients undergoing a THA, classified as ASA IV or had a later operative start time were all more likely to fail SDH discharge.
A comparison of hemiarthroplasty versus dynamic hip screw fixation for intertrochanteric femoral fractures: a systematic review
Authors: Chowdhury Alex K , Townsend Oliver , Edwards Max R
Published: July 2022

Introduction:

Intertrochanteric fractures are predominantly treated by dynamic hip screw (DHS) fixation. However, recent evidence has found acceptable clinical results following hemiarthroplasty for these fractures. Thus, a systematic review was conducted to compare hemiarthroplasty with DHS fixation for intertrochanteric fractures.

Methods:

A computerised search was performed, using the databases Medline, EMBASE, CINAHL and the Cochrane Central Register of Controlled Trials, with supplementation from Google Scholar and appropriate reference lists. Studies with comparative data comparing clinical outcomes of hemiarthroplasty versus DHS fixation were included. Data were extracted and quality assessment of the papers performed by 2 reviewers.

Results:

320 articles were independently reviewed by the investigators. A total of 10 studies met the inclusion criteria, comprising 2 randomised controlled trials and 8 cohort designs. 7 of the studies assessed unstable fracture patterns. There was no difference in operating time (SMD −1.169 min; 95% CI, −0.657 to 0.689) or blood transfusion volume (SMD−0.110 units; 95% CI, −0.520 to 0.891) between modalities. There was also no difference in length of stay (SMD −0.778 days; 95% CI, −0.606 to 0.336), mortality (RR 0.942; 95% CI, 0.749–1.183) or major complications. Hemiarthroplasty conferred significantly better Harris Hip Scores at 12 months (SMD 12.3; 95% CI, 0.0135–2.789) and allowed earlier weight-bearing than DHS fixation.

Discussion:

Qualitative and quantitative compilation of the included studies demonstrates hemiarthroplasty to result in better functional scores and a quicker time to weight-bearing than DHS fixation for intertrochanteric fractures. Results are comparable for other major parameters, including operative time, length of stay and mortality. Thus, hemiarthroplasty is a suitable alternative to DHS fixation for unstable intertrochanteric fractures in elderly patients.
Bone-Related Extramedullary Disease in Newly Diagnosed Myeloma Patients is an Independent Poor Prognostic Predictor
Authors: Wang Ying , Liu Aijun , Xu Tingting , Yin Jiahui , Chen Wenming
Published: July 2022

Background:

Bone-related extramedullary disease (EMD-B) is mass of clonal plasma cells derived from adjacent bone lesions and has obvious heterogeneities in clinical outcomes. This retrospective study aims to evaluate the treatment outcomes and long-term prognosis of newly diagnosed myeloma patients with EMD-B.

Methods:

This was a retrospective study conducted in Beijing Chaoyang Hospital from January 1, 2010 to December 31, 2019. Seventy-seven newly diagnosed multiple myeloma patients with EMD-B were selected. Propensity score matching (1:2) was used to match patients with and without EMD-B. After matching, 132 patients without extramedullary disease (non-EMD) were included in the study. All patients received bortezomib-based regimens as induction therapy.

Results:

After matching, baseline data of the 2 groups were comparable. The Cox regression analysis of patients with EMD-B showed that age, paravertebral lesions, and immunoglobulin D (IgD) type may have adverse effects on survival. Bone-related extramedullary disease at new diagnosis was a risk predictor of survival (hazard ration [HR] = 1.80, 95% confidence interval [CI]: 1.09-2.98, P = .022). The median survival time of the EMD-B group was significantly shorter than that of the non-EMD group (52 months vs 96 months, P = .043). Induction therapy did not show any significant differences in effectiveness between the 2 groups. Autologous stem cell transplantation (ASCT) significantly increased complete remission rate of patients with EMD-B (EMD-B vs non-EMD: no ASCT 15.7% vs 31.9%, P = .035; ASCT 42.3% vs 48.8%, P = .626) and improved their median overall survival rate (EMD-B vs non-EMD: no ASCT 49 months vs 75 months, P = .003; ASCT not reached vs 96 months, P = .505).

Conclusions:

This study demonstrated that newly diagnosed myeloma patients with EMD-B had poor outcomes, which could be improved by ASCT.
Feasibility documents as critical structuring objects: An approach to the study of documents in digital research production
Authors: Pawlicka-Deger Urszula
Published: July 2022

Documents have been increasingly recognised as important objects of investigation in Science and Technology Studies (STS); however, so far, much less attention has been given to the study of documents produced in Digital Humanities. The author proposes therefore to use the method of the ‘STS of documents’ and analyse Feasibility documents that aim to assess technical and design requirements based on research questions and to organise a project workflow. Drawing on the ethnography of King’s Digital Lab, the article investigates Feasibility documents produced by the lab within the Agile-based Software Development Lifecycle framework. The article aims to show that Feasibility documents (1) inform ethnographic work about lab workflow and management and in doing so, are able to capture the interconnectedness of work layers and practices; (2) enable an empirical analysis of digital research projects and the process of translation from research questions, to methods, to technical solutions; (3) are critical structuring objects that structure the research process and relationships between involved actors and are structured by local institutional strategies and decisions. The author conducts a ‘feasibility analysis’ that reveals the project management and development stages: the analytical process (the translation of research questions into technical solutions); the production process (the move from technical and design practices to research answers) and the infrastructure and management process (project workflow and sustainability solutions). Drawing on Agre’s critical technical practice and Digital Humanities’ theories of critical production, the article seeks to shift attention from end-product digital artefacts towards the complex process of their creation, which can unpack a range of social, technological and management issues. In doing so, it also aims to provide a methodological framework for the analysis of documents produced in Digital Humanities that have the potential to unearth new questions about the socio-technical nature of digital production.
Social workers’ experiences of psychological consultation on high risk youth: Helpful, unhelpful, and mediating elements
Authors: Sproull Alan J , Johnson Dan
Published: July 2022

Psychological consultation is a key means of informing care and practice with psychological theory and evidence. The current paper sought to investigate what elements of psychological consultation are useful for social workers when consulting on high-risk youth, due to the current gap in the literature. Seven social workers shared their experiences during one-to-one interviews. The data was analysed through thematic analysis and the emerging themes were organised into three categories: Helpful elements, such as a safe space, independent expertise, and a shared understanding; Unhelpful elements, including consultee anxiety and the unheard young person; A Mediating element in the form of feasible recommendations. The implications of these findings are discussed, as well as the limitations of this paper and recommendations for future research.
Engaging Leadership Competencies Through Population Health Policy Advocacy: A Review of the Evidence
Authors: Cropley Stacey , Hughes Monica , Belcik Kim
Published: July 2022

The purpose of this article is to identify the gaps in prelicensure nursing curriculum regarding the teaching and learning of policy advocacy and the necessary nursing leadership competencies that are significant in addressing social determinants of health at an upstream, policy level and to discuss how current prelicensure nursing curricula integrates and applies concepts of population health, policy advocacy, and nursing leadership competencies. The authors performed a conceptual review of the literature, analyzing the current, evidence-based scholarship on the topic in an effort to categorize and describe relevant concepts and outline a relationship between them, by combining the concept terms nursing leadership, policy advocacy, population health policy, nursing education, and social determinants of health. The conceptual review identified gaps in nursing education regarding the preparation of nursing graduates for leadership engagement at the policy level, which presents opportunities for future research and exploration. This article shares the thematic gaps, major findings, and recommendations that resulted. Continued effort should be invested into the development of more robust discussions and curriculum related to population health advocacy and the impact on population health in baccalaureate nursing educational programming.
Return-to-Activity: Exploration of Occupational Therapy in Outpatient Adult Concussion Rehabilitation
Authors: Roelke MaryAnn B , Jewell Vanessa D , Radomski Mary Vining
Published: July 2022

Literature is sparse related to how occupational therapy advances symptom management and role-activity resumption after concussion. We aim to describe the occupational therapy process of evaluation and intervention for adults with a history of concussion(s) and persisting symptoms. The qualitative descriptive study used focus groups of expert occupational therapy practitioners across practice settings. Content analysis with a deductive strategy, open coding, and an unconstrained matrix was used to determine the process portion of a logic model outlining how expert practitioners framed their approach to rehabilitation. Thirteen expert occupational therapy practitioners informed the development of a logic model describing the occupational therapy process linking resources to activities of evaluation and intervention enabling people to return to their everyday life roles at their highest capacity. This study yields a description of how occupational therapy practitioners, across practice settings, aid individuals in returning to everyday activities and life roles after concussion(s).
Selecting Resistance Training Exercises for Novices: A Delphi Study with Expert Consensus
Authors: Kompf Justin M. , Rhodes Ryan E. , Lee Sohee
Published: July 2022

Resistance training (RT) is a form of exercise that provides numerous health benefits. One barrier to participation may be the technical demands associated with some exercises. While recommendations for RT, including the number of repetitions, sets, rest, and training loads are established, recommendations for exercise selection have not been addressed. We used a Delphi-type method in three iterative surveys. In the first survey, 17 experts rated the technical complexity of 77 different strength training exercises as having low, moderate, or high technical demands. A second survey was generated based on the first, such that exercises receiving a majority high complexity vote were removed. In the second survey, experts rated the remaining exercises as either appropriate or too advanced for a novice. Exercises were deemed appropriate if 70% agreement was reached. Lastly, experts rated exercises as being appropriate for adults over the age of 60. Experts agreed that 41 different exercises were appropriate for novices and that 32 of the exercises were appropriate for novice adults over the age of 60. Our findings provide recommendations for program design to compliment already established recommendations for RT of repetitions, sets, rest periods, and training loads.
A brief review on the status of machining technology of fir-tree slots on aero-engine turbine disk
Authors: Jianhua Yu , Xun Li , Wenshuo Zhao , Bin Qin , Yu Zhang
Published: July 2022

The machining precision and its consistency of turbine disk fir-tree slots have a direct influence on the performance of aero-engine rotor components. However, the structural dimensions of fir-tree slot are small, and the cutting performance of materials is extremely poor, which lead to great difficulty in machining and very few available machining methods. With the application of new materials in the aero-engines, the machining precision and quality requirements of fir-tree slots are further improved. Therefore, many research achievements on the high-efficiency, high-quality and low-cost machining technology of turbine disk fir-tree slots have been obtained. By summarizing and classifying the machining methods of aero-engine turbine disk fir-tree slots, a brief review on the characteristics of different methods are presented in detail, which provide a reference for selecting the appropriate machining method of turbine disk fir-tree slots in the field of aviation manufacturing. Meanwhile, combined with the research and application status of machining technology of turbine disk fir-tree slots, it is presented that multi-process compound machining is an effective method to realize high-efficiency, high-quality and low-cost precision machining of turbine disk fir-tree slots, such as wire electro discharge machining (wire-EDM) and profiled grinding, wire electrochemical machining (wire-ECM) and profiled grinding, wire-EDM and broaching, milling and broaching.
A snake-inspired path planning algorithm based on reinforcement learning and self-motion for hyper-redundant manipulators
Authors: Lin Yue , Wang Jianming , Xiao Xuan , Qu Ji , Qin Fatao
Published: July 2022

Redundant manipulators are flexible enough to adapt to complex environments, but their controller is also required to be specific for their extra degrees of freedom. Inspired by the morphology of snakes, we propose a path planning algorithm named Swinging Search and Crawling Control, which allows the snake-like redundant manipulators to explore in complex pipeline environments without collision. The proposed algorithm consists of the Swinging Search and the Crawling Control. In Swinging Search, a collision-free manipulator configuration that of the end-effector in the target point is found by applying reinforcement learning to self-motion, instead of designing joint motion. The self-motion narrows the search space to the null space, and the reinforcement learning makes the algorithm use the information of the environment, instead of blindly searching. Then in Crawling Control, the manipulator is controlled to crawl to the target point like a snake along the collision-free configuration. It only needs to search for a collision-free configuration for the manipulator, instead of searching collision-free configurations throughout the process of path planning. Simulation experiments show that the algorithm can complete path planning tasks of hyper-redundant manipulators in complex environments. The 16 degrees of freedom and 24 degrees of freedom manipulators can achieve 83.3% and 96.7% success rates in the pipe, respectively. In the concentric pipe, the 24 degrees of freedom manipulator has a success rate of 96.1%.
The gaslighting of authentic leadership revisited
Authors: Gardner William L , McCauley Kelly Davis
Published: July 2022

Authentic leadership theory (ALT) has become the target for considerable criticism of its conceptual grounding and the methods used for its empirical investigation. Mats Alvesson and Katja Einola (2019) have led the charge in advancing skepticism about ALT by warning of the pitfalls of excessive positivity in leadership research, using ALT as an illustrative example. In a subsequent exchange of letters, the cases against and for authentic leadership were advanced by Alvesson and Einola and Gardner and Karam, respectively (Gardner et al., 2021). As an extension to this debate, Einola and Alvesson (2021) advanced a provocative argument that ALT is not only misguided, but “perilous” to those who believe in it. We felt compelled to reply to this claim by documenting erroneous elements of their arguments that we contend constitute “academic gaslighting” in that they may cause leadership scholars and practitioners to inappropriately discount empirical evidence and their own lived experiences of authentic leadership (Gardner and McCauley, 2022). Alvesson and Einola (2022), in turn, replied with a lengthy defense of their position in which they assert that rather than engaging in gaslighting, their critique constitutes an effort to “enlighten” ALT. In this final entry in this academic exchange, we identify areas of agreement as well as continued disagreements in our exchange and take issue, yet again, with their argument that ALT is inherently dangerous for scholars and practitioners alike. We conclude by asking readers to be wary of these efforts to gaslight ALT and instead rely on the extant empirical evidence and their own lived experiences to draw their own conclusions about the merits of authentic leadership as a topic for academic inquiry and an approach for practicing leadership in the workplace.
Cognitive segmentation and fluid reasoning in childhood
Authors: O’Brien Sinéad , Mitchell Daniel J , Duncan John , Holmes Joni
Published: July 2022

The ability to solve novel complex problems predicts success in a wide range of areas. Recent research suggests that the ability to cognitively segment complex problems into smaller parts constrains nonverbal reasoning in adults. This study aimed to test whether cognitively segmenting problems improves nonverbal reasoning performance for children as it does for adults. A total of 115 children aged 6–10 years completed two versions of a modified traditional matrix reasoning task in which demands on working memory, integration, and processing speed were minimised, such that the only significant requirement was to break each problem into its constituent parts. In one version of the task, participants were presented with a traditional 2×2 Matrix and asked to draw the missing matrix item into a response box below. In a second version, the problem was broken down into its component features across three separate cells, reducing the need for participants to segment the problem. As with adults, performance was better in the condition in which the problems were separated into component parts. Children with lower fluid intelligence did not benefit more in the separated condition than children with higher fluid intelligence, and there was no evidence that segmenting problems was more beneficial for younger than older children. This study demonstrates that cognitive segmentation is a critical component of complex problem-solving for children, as it is for adults. By forcing children to focus their attention on separate parts of a complex visual problem, their performance can be dramatically improved.
Experiencing misinformation: The effect of pre-exposure warnings and debunking on psychic beliefs
Authors: Kuhn Gustav , Ortega Jeniffer , Simmons Keir , Thomas Cyril , Mohr Christine
Published: July 2022

Misinformation can have a detrimental impact on our beliefs, and it is therefore necessary to understand the cognitive mechanism by which false information is integrated or can be changed. In two experiments, we worked with fake psychic demonstrations, because observers easily adopt the experience as reflecting a “true” psychic event. We manipulated the availability of alternative explanations by providing a general warning that the performer is a magician with no psychic abilities (Experiment 1) or disclosing afterwards how the fake demonstration had been staged (Experiment 2). In Experiment 1, witnessing the psychic demonstration significantly increased participants’ psychic beliefs, even though they had been warned. However, providing the alternative explanation about the deceptive method mitigated this effect. In Experiment 2, the realisation of deception significantly reduced participants’ psychic beliefs directly after the performance and remained reduced 1 week later.
Community perspectives of terrorism and the Nigerian government’s counterterrorism strategies: A systematic review
Authors: Ike Tarela Juliet , Antonopoulos Georgios A , Singh Danny
Published: July 2022

Terrorism and insecurity pose significant global concern and Nigeria has been bedevilled by Boko Haram – a terrorist group deemed one of the deadliest terrorist groups in the world. While the Nigerian government have adopted concerted counterterrorism approaches to tackle terrorism, very limited success seems to have been achieved and the synthesis of community perspectives of government interventions appears lacking. This study makes an original and significant contribution by adopting a systematic review approach to synthesise existing studies on community perspective on the drivers of involvement in terrorism and on Nigerian government’s responses. Six databases were searched, and 21 studies met the review criteria. Informed by thematic analysis principles and the conceptual framework of synthesis, the study finds a sense of disconnect between the government approach to counterterrorism and community perspectives. The study recommends a context-specific community informed response to insecurity towards improving existing counterterrorism measures.
Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis
Authors: Parra-Ferro Mauricio , Justice Jeb M. , Lobo Brian C. , Munger Steven D. , Schlosser Rodney J. , Mulligan Jennifer K.
Published: July 2022

Background

Nasal mucus is proving to be a useful means by which to study the pathogenesis of chronic rhinosinusitis (CRS). Given the increase in publications examining nasal mucus and the lack of a review on this topic, we will focus on this noninvasive approach to studying CRS. Particular attention will be drawn towards inflammatory cytokines and biomarkers and their influence on disease severity.

Methods

A literature review of papers published in English pertaining to nasal mucus was performed using the PubMed database. The search utilized combinations of the following keywords: sinusitis, polyps, sample collection, nasal mucus, or nasal secretion. Studies solely on acute or bacterial sinusitis, allergic rhinitis, or cystic fibrosis were not included.

Results

A wide variety of materials and methods have been used to collect nasal mucus. Numerous assay types have been performed with the most common being ELISA, cytometric bead array, and proteomics. Most studies have focused on examining the levels of Th1/Th2 cytokines along with chemokines associated with type 2 immunity. Other factors identified include growth factors, senescence-associated proteins, complement, and antimicrobial defenses have also been identified. Nasal mucus cytokines have proven useful in cluster analysis and predicting postoperative improvement in Sino-nasal Outcome Test (SNOT-22) scores. One limitation of the use of nasal mucus is that some studies have suggested that nasal mucus does not always reflect the tissue microenvironment.

Conclusions

Nasal mucus represents a critical tool by which to examine the sinonasal microenvironment in a noninvasive manner. Unlike studies of tissue, it can be utilized in both surgically and medically managed patients and avoids the trauma of biopsies. However, studies are still needed to determine the most effective method for nasal mucus collection. Studies should also take care to confirm that nasal mucus markers do, in fact, reflect the levels of the product studied in the tissue.
Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome
Authors: McDonnell Tara , Cussen Leanne , McIlroy Marie , O’Reilly Michael W.
Published: July 2022

Polycystic ovary syndrome (PCOS) is the most common endocrine condition affecting women. It has traditionally been viewed as a primarily reproductive disorder; however, it is increasingly recognized as a lifelong metabolic disease. Women with PCOS are at increased risk of insulin resistance (IR), type 2 diabetes mellitus, non-alcoholic fatty liver disease and cardiovascular disease. Although not currently a diagnostic criterion, IR is a cardinal pathophysiological feature and highly prevalent in women with PCOS. Androgens play a bidirectional role in the pathogenesis of IR, and there is a complex interplay between IR and androgen excess in women with PCOS. Skeletal muscle has a key role in maintaining metabolic homeostasis and is also a metabolic target organ of androgen action. Skeletal muscle is the organ responsible for the majority of insulin-mediated glucose disposal. There is growing interest in the relationship between skeletal muscle, androgen excess and mitochondrial dysfunction in the pathogenesis of metabolic disease in PCOS. Molecular mechanisms underpinning defects in skeletal muscle dysfunction in PCOS remain to be elucidated, but may represent promising targets for future therapeutic intervention. In this review, we aim to explore the role of skeletal muscle in metabolism, focusing particularly on perturbations in skeletal muscle specific to PCOS as observed in recent molecular and in vivo human studies. We review the possible role of androgens in the pathophysiology of skeletal muscle abnormalities in PCOS, and identify knowledge gaps, areas for future research and potential therapeutic implications. Despite increasing interest in the area of skeletal muscle dysfunction in women with PCOS, significant challenges and unanswered questions remain, and going forward, novel innovative approaches will be required to dissect the underlying mechanisms.
Scaffolding design to increase reading comprehension for learners of English through online strategy training
Authors: Uçak Gamze , Kartal Günizi
Published: July 2022

This study explored the effects of reading strategy training delivered online through an experimental scaffolding tool in comparison to similar training delivered by a teacher, and a control condition. The instructional design of the tool followed scaffolding design guidelines, reciprocal teaching model, and principles of multimedia design. The training provided metacognitive reading strategy instruction to improve reading comprehension through multiple strategies using multiple texts. The participants were 87 college students studying English as a Foreign Language (EFL) at an English medium university in Turkey. At pretest, the control group had scored significantly higher in reading comprehension based on a standardized measure. Both of the experimental groups significantly improved their reading comprehension and metacognitive strategy awareness, while the control group’s reading and engagement scores decreased. The in-class experimental group also improved on the engagement scale. No significant difference was found between the experimental groups or compared to the control group in reading comprehension. The findings have implications regarding institutional policies for teaching reading in EFL and online reading strategy design at the tertiary level.
Eating ourselves to death: How food is a drug and what food abuse costs
Authors: Robinson Matthew
Published: July 2022

The objective of this paper is to examine definitions of the terms “drug,” “drug use, “drug abuse,” and “addiction” to determine if the most commonly consumed foods in America are similar or consistent with drug use, abuse, and addiction. The methodology consists of reviewing published studies in the “food addiction” literature to determine if any consensus on the issue is achieved. Further, the author analyzes research on harms (including illness, death, medical costs and productivity losses) of illicit drugs, licit drugs, and foods. The author finds evidence that some food consumption is consistent with drug use and drug abuse, and that food addiction is real. Further, the harms caused by the unhealthy foods we eat dwarf those caused by crime and illegal drugs combined. Based on the data, the author suggests we reprioritize what we believe to be dangerous and “criminal” as well as rethink the “war on drugs.”
The use of virtual complementary and integrative therapies by neurology outpatients: An exploratory analysis of two cross-sectional studies assessing the use of technology as treatment in an academic neurology department in New York City
Authors: Minen Mia T , Busis Neil A , Friedman Steven , Campbell Maya , Sahu Ananya , Maisha Kazi , Hossain Quazi , Soviero Mia , Verma Deepti , Yao Leslie , Foo Farng-Yang A , Bhatt Jaydeep M , Balcer Laura J , Galetta Steven L , Thawani Sujata
Published: July 2022

Background

Prior to the COVID-19 pandemic, about half of patients from populations that sought care in neurology tried complementary and integrative therapies (CITs). With the increased utilization of telehealth services, we sought to determine whether patients also increased their use of virtual CITs.

Methods

We examined datasets from two separate cross-sectional surveys that included cohorts of patients with neurological disorders. One was a dataset from a study that examined patient and provider experiences with teleneurology visits; the other was a study that assessed patients with a history of COVID-19 infection who presented for neurologic evaluation. We assessed and reported the use of virtual (and non-virtual) CITs using descriptive statistics, and determined whether there were clinical characteristics that predicted the use of CITs using logistic regression analyses.

Findings

Patients who postponed medical treatment for non-COVID-19-related problems during the pandemic were more likely to seek CITs. Virtual exercise, virtual psychotherapy, and relaxation/meditation smartphone applications were the most frequent types of virtual CITs chosen by patients. In both studies, age was a key demographic factor associated with mobile/virtual CIT usage.

Interpretations

Our investigation demonstrates that virtual CIT-related technologies were utilized in the treatment of neurologic conditions during the pandemic, particularly by those patients who deferred non-COVID-related care.
Analysis of depression in social media texts through the Patient Health Questionnaire-9 and natural language processing
Authors: Kim Nam Hyeok , Kim Ji Min , Park Da Mi , Ji Su Ryeon , Kim Jong Woo
Published: July 2022

Objective

Although depression in modern people is emerging as a major social problem, it shows a low rate of use of mental health services. The purpose of this study was to classify sentences written by social media users based on the nine symptoms of depression in the Patient Health Questionnaire-9, using natural language processing to assess naturally users’ depression based on their results.

Methods

First, train two sentence classifiers: the Y/N sentence classifier, which categorizes whether a user’s sentence is related to depression, and the 0–9 sentence classifier, which further categorizes the user sentence based on the depression symptomology of the Patient Health Questionnaire-9. Then the depression classifier, which is a logistic regression model, was generated to classify the sentence writer’s depression. These trained sentence classifiers and the depression classifier were used to analyze the social media textual data of users and establish their depression.

Results

Our experimental results showed that the proposed depression classifier showed 68.3% average accuracy, which was better than the baseline depression classifier that used only the Y/N sentence classifier and had 53.3% average accuracy.

Conclusions

This study is significant in that it demonstrates the possibility of determining depression from only social media users’ textual data.
Self-Esteem and Real Self and False Self Presentation on Facebook Among Emerging Adults: The Moderating Role of Social Anxiety
Authors: Michikyan Minas
Published: July 2022

This study examined the individual and interactive associations between self-esteem, social anxiety, and real and false self-presentation on Facebook. Data came from a college sample of 216 emerging adult Facebook users (M age ≈ 23, 171 women). Findings indicate that social anxiety moderated the association between self-esteem and false self-presentation, such that emerging adults low in self-esteem and high in social anxiety may present themselves in a more deceptive, inauthentic, and socially desirable manner on Facebook. Results also suggest that emerging adults with higher self-esteem may present their real self (authentic) more on Facebook, whereas emerging adults with lower self-esteem may present their false self (deceptive and socially desirable) to a greater extent. Findings also indicate that socially anxious emerging adults may present their false self more on Facebook, motivated by social desirability and self-exploration. Implications for interpersonal experiences (e.g., social acceptance and social rejection/exclusion) during emerging adulthood are discussed.
The Effect of Preoperative Marijuana Use on Surgical Outcomes, Patient-Reported Outcomes, and Opioid Consumption Following Lumbar Fusion
Authors: D’Antonio Nicholas D. , Lambrechts Mark J. , Heard Jeremy C. , Siegel Nicholas , Karamian Brian A. , Huang Angela , Canseco Jose A. , Woods Barrett , Kaye Ian David , Hilibrand Alan S. , Kepler Christopher K. , Vaccaro Alexander R. , Schroeder Gregory D.
Published: July 2022

Study Design

Retrospective Cohort Study.

Objectives

To (1) investigate the effect of marijuana use on surgical outcomes following lumbar fusion, (2) determine how marijuana use affects patient-reported outcomes measures (PROMs), and (3) determine if marijuana use impacts the quantity of opioids prescribed.

Methods

Patients > 18 years of age who underwent primary one- or two-level lumbar fusion with preoperative marijuana use at our institution were identified. A 3:1 propensity match incorporating patient demographics and procedure type was conducted to compare preoperative marijuana users to non-marijuana users. Patient demographics, surgical characteristics, surgical outcomes (90-day all-cause and 90-day surgical readmissions, reoperations, and revision surgeries), pre- and postoperative narcotic usage, and PROMs were compared between groups. Multivariate regression models were created to determine the effect of marijuana on surgical reoperations patient-reported outcomes (PROMs) 1-year postoperatively.

Results

Of the 259 included patients, 65 used marijuana preoperatively. Multivariate logistic regression analysis demonstrated that marijuana use (OR = 2.28, P = .041) significantly increased the likelihood of having a spine reoperation. No other surgical outcome was found to be significantly different between groups. Multivariate linear regression analysis showed that marijuana use was not significantly associated with changes in 1-year postoperative PROMs (all, P > .05). The quantity of pre- and postoperative opioids prescriptions was not significantly different between groups (all, P > .05).

Conclusions

Preoperative marijuana use increased the likelihood of a spine reoperation for any indication following lumbar fusion, but it was not associated with 90-day all cause readmission, surgical readmission, the magnitude of improvement in PROMs, or differences in opioid consumption.

Level of Evidence

III
Growth plate injury in children: Review of literature on PubMed
Authors: Sananta Panji , Lesmana Albert , Alwy Sugiarto Muhammad
Published: July 2022

Growth plate injury is a debilitating condition for children. To our knowledge, there is currently no systematic review regarding the complication of epiphyseal injury. Thus, the authors would like to conduct a systematic review regarding this topic. The following strategy was used: the terms used on the PubMed search engine were “growth plate injuries complications.” Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to perform the comprehensive data collection. The initial PubMed search yielded 341 titles and 81 articles included according to the inclusion criteria, but 20 articles were eliminated according to the exclusion criteria. The final total number of articles was 61. The epiphyseal injury usually ends with a good functional outcome, although some serious complication risk remains.
The application of geographic information system for dengue epidemic in Southeast Asia: A review on trends and opportunity
Authors: Sekarrini Cipta Estri , Sumarmi  , Bachri Syamsul , Taryana Didik , Giofandi Eggy Arya
Published: July 2022

The infectious disease dengue hemorrhagic fever remains an unresolved global problem, with climatic conditions and the location of areas located at the equator more often infected with dengue fever. Various modeling approaches have been employed for the development of a dengue risk map. The geographic information system approach was used as an instrument in applying mathematical algorithms to process field vector data into a preventive objective which is studied, then the application of remote sensing provides spatial-temporal data related to land use/land cover data sources as other variable categories. Map of hotspots for dengue fever cases is used to identify the risk of dengue fever areas by applying various complex methodologies, analysis, and visualization of advanced data are needed for its application in public health. In the last 10 years, the increase in the publication of dengue hemorrhagic fever in Southeast Asia in reputable international journals has increased significantly.
Revealing Perceptional and Cognitive Mechanisms in Static and Dynamic Cocktail Party Listening by Means of Error Analyses
Authors: Wächtler Moritz , Kessler Josef , Walger Martin , Meister Hartmut
Published: July 2022

In cocktail party situations multiple talkers speak simultaneously, which causes listening to be perceptually and cognitively challenging. Such situations can either be static (fixed target talker) or dynamic, meaning the target talker switches occasionally and in a potentially unpredictable way. To shed light on the perceptional and cognitive mechanisms in static and dynamic cocktail party situations, we conducted an analysis of error types that occur during a multi-talker speech recognition test. The error analysis distinguished between misunderstood or omitted words (random errors) and target-masker confusions. To investigate the effects of aging and hearing impairment, we compared data from three listener groups, comprised of young as well as older adults with and without hearing loss. In the static condition, error rates were generally very low, except for the older hearing-impaired listeners. Consistent with the assumption of decreased audibility, they showed a notable amount of random errors. In the dynamic condition, errors increased compared to the static condition, especially immediately following a target talker switch. Those increases were similar for random and confusion errors. The older hearing-impaired listeners showed greater difficulties than the younger adults in trials not preceded by a switch. These results suggest that the load associated with dynamic cocktail party listening affects the ability to focus attention on the talker of interest and the retrieval of words from short-term memory, as indicated by the increased amount of confusion and random errors. This was most pronounced in the older hearing-impaired listeners proposing an interplay of perceptual and cognitive mechanisms.