bluuebunny/crossref_metadata_2025 huggingface dataset:
How Prospective Physical Medicine and Rehabilitation Trainees Rank Residency Training Programs
Authors: Auriemma Michael J. , Whitehair Curtis L.
Published: September 2017

Background

Since the inception of the National Resident Matching Program, multiple studies have investigated the factors applicants consider important to ranking prospective residency programs. However, only 2 previous studies focused on prospective physical medicine and rehabilitation (PM&R) trainees, and the most recent of these studies was published in 1993. It is unknown whether these previous studies are reflective of current prospective PM&R residents.

Objective

To assess various factors that contribute to prospective PM&R residents' decision making in choosing a residency program and compare these findings with previous studies.

Design

An anonymous, voluntary questionnaire.

Setting

A single PM&R residency program.

Participants

All applicants to a single PM&R residency program.

Methods

All applicants to our PM&R residency program were invited to participate in a 44‐item, 5‐point Likert‐based questionnaire. Applicants were asked to rate the importance of various factors as they related to constructing their residency rank list.

Main Outcome Measurements

Means and standard deviations were calculated for items included in the survey.

Results

A response rate of 26% was obtained, with the responses of 98 applicants (20%) ultimately analyzed. The highest rated factors included “perceived happiness of current residents,” “opportunities for hands‐on procedure training,” “perceived camaraderie among current residents,” “perceived camaraderie among faculty and current residents,” “perceived quality of current residents,” and “perceived work/life balance among current residents.” Although male and female respondents demonstrated similar ranking preferences, an apparent difference was detected between how genders rated the importance of “whether the program projects a favorable environment for women” and “whether the program projects a favorable environment for minorities.” As compared with previous PM&R applicants, current prospective trainees seem to place greater importance on skill acquisition over didactic teaching.

Conclusion

Prospective PM&R residents highly value subjective perceptions of prospective PM&R training programs and the ability to obtain hands‐on procedural experience.

Level of Evidence

Not applicable
Navigating Global Business
Authors: Ronen Simcha , Shenkar Oded
Published: September 2017

Navigating Global Business integrates and synthesizes all available country cluster studies into a nested meta-structure accompanied by eco-cultural correlates that distinguish amongst clusters. The broad range of analyses will appeal to researchers and practitioners, seasoned multi-firm executives, those in small firms seeking internationalization, and anyone intrigued by the greater question of human diversity. The book covers key work-related cultural dimensions for much of the world, and includes examples of applications in most business areas. Also exhibited are the correlates of culture, some of which, such as language and religion, speak to the origin of cultural variations in addition to illustrating key variants of the global terrain. Finally, the authors examine how patterns might have changed over time, providing a rigorous and realistic assessment of the fruits of globalization.
Herder's Hermeneutics
Authors: Gjesdal Kristin
Published: September 2017

Through a detailed study of Herder's Enlightenment thought, especially his philosophy of literature, Kristin Gjesdal offers a new and sometimes provocative reading of the historical origins and contemporary challenges of modern hermeneutics. She shows that hermeneutic philosophy grew out of a historical, anthropological, and poetic discourse in the mid-eighteenth century and argues that, as such, it represents a rich, stimulating, and relevant engagement with the potentials and limits of human meaning and understanding. Gjesdal's study broadens our conception of hermeneutic philosophy - the issues it raises and the answers it offers - and underlines the importance of Herder's contribution to the development of this discipline. Her book will be highly valuable for students and scholars of eighteenth-century thought, especially those working in the fields of hermeneutics, aesthetics, and European philosophy.
Acoustical Analysis of Enclosure Design Parameters for Microspeaker System
Authors: Chang J. R. , Wang C. N.
Published: September 2017

Microspeakers are key components of mobile devices in current consumer products; moreover, the user experience of multimedia products plays an essential role. The objective of this study was to investigate the acoustic performance of microspeakers in different enclosure parameters for mobile devices. Two methodologies are performed. The first model is an electro-mechano-acoustical model (EMA) of microspeaker along with distribution model of enclosure effect; the 2nd model, the details of diaphragms are taken into account in calculating the distribution models of microspeaker with enclosure parameters. They were combined and applied to determine microspeaker performance levels for mobile devices. Two methodologies show acceptable agreement with experimental results. The distribution model can well simulate the high frequency response than lumped model of microspeaker. The results can predict microspeaker system performance before industrial design and mechanism placement processes are executed.
Two-Dimensional Dynamic Ground Effect on a Swimming Undulating Plate: A Parametric Study
Authors: Sierra D. M. , Guo J. H.
Published: September 2017

The dynamic ground effect enhances the swimming of fish. The dynamic ground effect affects the kinematic conditions of fish, causing them to swim more efficiently. However, predicting the degree to which the dynamic ground effect can improve the swimming performance of fish is difficult. The dynamic ground effect can potentially save energy for biomimetic underwater vehicles. Therefore, a theoretical model was developed to investigate the effect of a planar boundary on the swimming performance of a two-dimensional undulating plate. General expressions for the thrust, power input, efficiency, and energy loss of the plate were obtained. As examples, cases in which an undulating plate with linearly varying amplitude swam far from and close to a wall under a range of different kinematic conditions were studied. The dynamic ground effect improved the swimming performance of the plate by reducing the power input while maintaining an almost constant thrust; the degree of improvement depended on the kinematic conditions of the plate. Furthermore, the swimming performance of the plate was improved over a range of distances from the wall; this range of distances also depended on the kinematic conditions of the plate.
Scrutiny of Unsteady Flow and Heat Transfer in a Backward-Facing Step Under Pulsating Nanofluid Blowing Using the Eulerian-Eulerian Approach
Authors: Zahmatkesh I. , Torshizi E.
Published: September 2017

In this paper, unsteady flow and heat transfer of water flow in a backward-facing step under pulsating nanofluid blowing are studied numerically. Attention is focused to examine the impact of this type of blowing and its pertinent parameters on the heat transfer performance and to detect possible non-equilibrium between the base fluid and the nanoparticles inside the flow field. To this aim, the Eulerian-Eulerian two-phase model is adopted. This approach consists of separate equation sets for the base fluid and the nanoparticles. So, it provides details of the flow field for each of the constituents, separately. Computations are undertaken for different cases and the consequences of the frequency, amplitude, and the mean velocity of the pulsating blowing as well as the type, diameter, and the volume fraction of the nanoparticles therein on the heat transfer characteristics are analyzed. It is found that in addition to thermal conductivity of the blown nanoparticles, their penetration into the water flow is an important trait that has a momentous role on the heat transfer rate. In the current Eulerian-Eulerian simulation, temperature distributions of the base fluid and the nanoparticles are similar but the corresponding velocity fields are quite distinct. This reveals a kind of non-equilibrium between the base fluid and the nanoparticles inside the flow that invalidates equilibrium approaches (e.g., the single-phase model or the two-phase mixture model) for the description of the problem.
Oxygen – the forgotten nutrient
Authors: Trayhurn Paul
Published: September 2017

O2 is essential for the maintenance and growth of aerobic animals, similar to the essentiality of what are classically considered nutrients. Nevertheless, O2 is not customarily regarded as a nutrient, this reflecting the route by which it enters the body – through the lungs or gills in vertebrates, rather than via the mouth and gastrointestinal tract. A relative deficiency of O2 occurs at high altitudes and during deep-sea diving, to which distinct adaptations occur. Deficiency is also evident in lung diseases such as emphysema. Without O2, mitochondrial respiration and oxidative phosphorylation cannot take place. At a molecular level, cells adapt to O2 deficiency by switching from oxidative metabolism to anaerobic glycolysis and there are changes in the expression of a multiplicity of genes, driven by hypoxia-sensitive transcription factors, particularly hypoxia-inducible factor-1. It is argued that O2 should be fully included within the remit of nutritional science alongside the other essential macronutrients.
QUANTISATION SPACES OF CLUSTER ALGEBRAS
Authors: GELLERT FLORIAN , LAMPE PHILIPP
Published: September 2017

The article concerns the existence and uniqueness of quantisations of cluster algebras. We prove that cluster algebras with an initial exchange matrix of full rank admit a quantisation in the sense of Berenstein-Zelevinsky and give an explicit generating set to construct all quantisations.
Restoration and Reaction: Reinterpreting the Marian Church
Authors: FREEMAN THOMAS S.
Published: September 2017

Although the reign of Mary i (1553–8) was a tumultuous and eventful one, for over four hundred years there was little debate about it or about the queen's efforts to restore Catholicism to England. The reign was almost universally perceived as poor, nasty, brutish and short-lived and the restoration of Catholicism was believed to have been doomed to failure, both because the burning of heretics offended English sensibilities and because Protestantism was already so deeply embedded in England that it could not be uprooted. Yet towards the end of the twentieth century, the tectonic plates of historical research began to shift and the resulting tremors altered the historiographical landscape of Mary's reign, and indeed of the English Reformation.
A new generation computerised metacognitive cognitive remediation programme for schizophrenia (CIRCuiTS): a randomised controlled trial
Authors: Reeder C. , Huddy V. , Cella M. , Taylor R. , Greenwood K. , Landau S. , Wykes T.
Published: September 2017

Background

Cognitive remediation (CR) is a psychological therapy, which improves cognitive and social functioning in people with schizophrenia. It is now being implemented within routine clinical services and mechanisms of change are being explored. We designed a new generation computerised CR programme, CIRCuiTS (Computerised Interactive Remediation of Cognition – a Training for Schizophrenia), to enhance strategic and metacognitive processing, with an integrated focus on the transfer of cognitive skills to daily living. This large trial tested its feasibility to be delivered in therapist-led and independent sessions, and its efficacy for improved cognitive and social functioning.

Methods

A two arm single blind randomised superiority trial comparing CIRCuiTS plus treatment-as-usual (TAU) with TAU alone in 93 people with a diagnosis of schizophrenia. Cognitive, social functioning and symptom outcomes were assessed at pre- and post-therapy and 3 months later.

Results

85% adhered to CIRCuiTS, completing a median of 28 sessions. There were significant improvements in visual memory at post-treatment (p = 0.009) and follow-up (p = 0.001), and a trend for improvements in executive function at post-treatment (p = 0.056) in favour of the CIRCuiTS group. Community function was also differentially and significantly improved in the CIRCuiTS group at post-treatment (p = 0.003) but not follow-up, and was specifically predicted by improved executive functions.

Conclusions

CIRCuiTS was beneficial for improving memory and social functioning. Improved executive functioning emerges as a consistent predictor of functional gains and should be considered an important CR target to achieve functional change. A larger-scale effectiveness trial of CIRCuiTS is now indicated.
It is logically impossible for everlasting God to fall into boredom
Authors: GELLMAN JEROME
Published: September 2017

This article argues that everlasting God can be in boredom, but cannot fall into boredom. Hence, the argument by Andric and Tanyi (2017) in this journal that God could not be everlasting in time, because God would fall into boredom, is shown to be unsound, since it is logically impossible for God to fall into boredom.
Evaluating the quality of care received in long-term care facilities from a consumer perspective: development and construct validity of the Consumer Choice Index – Six Dimension instrument
Authors: MILTE RACHEL , RATCLIFFE JULIE , BRADLEY CLARE , SHULVER WENDY , CROTTY MARIA
Published: September 2017

The Consumer Choice Index – Six Dimension (CCI-6D) is a new instrument designed specifically to evaluate the quality of care received in long-term care from a consumer perspective. This study aims to demonstrate the construct validity of the CCI-6D. Older residents living in long-term care facilities and proxy family carers (where severely impaired cognition precluded resident consent) participated as consumers of long-term care. Data collected included the CCI-6D instrument, quality of life, physical function and characteristics of the care facility. Relationships between these variables and the CCI-6D dimensions were assessed and analysed through chi-squared and Kruskal–Wallis tests to assess the construct validity of each dimension. Of 430 eligible consumers, a total of 253 completed the questionnaire, of whom 68 (27%) were residents and 185 (73%) were informal carer proxy participants. There was strong evidence of construct validity of the dimensions relating to adequacy of individual care time, access to outside and gardens, access to meaningful activities and flexibility of care. There was more moderate evidence of validity of the home-like own room and shared spaces items, which may be in part due to difficulty in identifying strong discriminatory variables for comparison with these items. The results also indicate a strong association between ‘processes’ of care delivery (as measured by the CCI-6D) and quality of life of care recipients.
Trapping and acceleration of short electron bunches in the laser wakefields
Authors: Andreev N.E. , Baranov V.E. , Matevosyan H.H.
Published: September 2017

The processes of trapping, compression, and acceleration of short electron bunches externally injected into the wakefields generated by intense femtosecond laser pulse in a plasma channel are analyzed and optimized. The influence of the laser non-linear dynamics to the longitudinal bunch compression and impact of the beam loading effect (self-action of the bunch charge) to the finite energy and the energy spread of the accelerated electrons are investigated. The limitations to the charge of accelerated electron bunch determined by the requirement of a small width of the electron energy distribution of the bunch are found.
SIEGMUND DUALITY FOR MARKOV CHAINS ON PARTIALLY ORDERED STATE SPACES
Authors: Lorek Paweł
Published: September 2017

For a Markov chain on a finite partially ordered state space, we show that its Siegmund dual exists if and only if the chain is Möbius monotone. This is an extension of Siegmund's result for totally ordered state spaces, in which case the existence of the dual is equivalent to the usual stochastic monotonicity. Exploiting the relation between the stationary distribution of an ergodic chain and the absorption probabilities of its Siegmund dual, we present three applications: calculating the absorption probabilities of a chain with two absorbing states knowing the stationary distribution of the other chain; calculating the stationary distribution of an ergodic chain knowing the absorption probabilities of the other chain; and providing a stable simulation scheme for the stationary distribution of a chain provided we can simulate its Siegmund dual. These are accompanied by concrete examples: the gambler's ruin problem with arbitrary winning/losing probabilities; a non-symmetric game; an extension of a birth and death chain; a chain corresponding to the Fisher–Wright model; a non-standard tandem network of two servers, and the Ising model on a circle. We also show that one can construct a strong stationary dual chain by taking the appropriate Doob transform of the Siegmund dual of the time-reversed chain.
The World Court's Jurisdictional Formalism and its Lost Market Share: TheMarshall IslandsDecisions and the Quest for a Suitable Dispute Settlement Forum for Multilateral Disputes
Authors: PROULX VINCENT-JOËL
Published: September 2017

On 5 October 2016, the International Court of Justice (ICJ, the Court) rendered three judgments declining to take jurisdiction in theMarshall Islandscases, in which that state alleged that India, Pakistan, and the United Kingdom violated their nuclear disarmament obligations under the Treaty on the Non-Proliferation of Nuclear Weapons and customary international law. In declining to take jurisdiction, the Court further confirmed its recent shift to jurisdictional formalism, initiated inGeorgiav.Russiaand confirmed in bothBelgiumv.Senegaland theAlleged Violations (Nicaraguav.Colombia)judgment. What is more, the Court heightened the burden of proving the existence of a dispute by incorporating an ‘objective awareness’ requirement in its analysis. The present contribution critically situates the Court's judgments within the context of the law of state responsibility and global security, with particular emphasis on the broader implications going forward. It first explores the principal features of the Court's formalistic shift on jurisdictional matters in the cases, setting the stage for the subsequent discussion. The article then turns to the broader implications of these decisions for state responsibility, taking into consideration that the ‘disputes’ submitted to the Court are not strictly bilateral in nature. My ambition is also to highlight the nexus between jurisdictional issues, state responsibility law, and broader questions of access to justice in multilateral disputes. By way of conclusion, the article highlights the importance of identifying creative solutions in a post-Marshall Islandsworld, suggesting the UN General Assembly as a law-making facilitator and the UN Security Council as an alternate – albeit imperfect – dispute settlement forum to tackle multilateral disputes with global security implications.
CCG supertagging with bidirectional long short-term memory networks
Authors: KADARI REKIA , ZHANG YU , ZHANG WEINAN , LIU TING
Published: September 2017

Neural Network-based approaches have recently produced good performances in Natural language tasks, such as Supertagging. In the supertagging task, a Supertag (Lexical category) is assigned to each word in an input sequence. Combinatory Categorial Grammar Supertagging is a more challenging problem than various sequence-tagging problems, such as part-of-speech (POS) tagging and named entity recognition due to the large number of the lexical categories. Specifically, simple Recurrent Neural Network (RNN) has shown to significantly outperform the previous state-of-the-art feed-forward neural networks. On the other hand, it is well known that Recurrent Networks fail to learn long dependencies. In this paper, we introduce a new neural network architecture based on backward and Bidirectional Long Short-Term Memory (BLSTM) Networks that has the ability to memorize information for long dependencies and benefit from both past and future information. State-of-the-art methods focus on previous information, whereas BLSTM has access to information in both previous and future directions. Our main findings are that bidirectional networks outperform unidirectional ones, and Long Short-Term Memory (LSTM) networks are more precise and successful than both unidirectional and bidirectional standard RNNs. Experiment results reveal the effectiveness of our proposed method on both in-domain and out-of-domain datasets. Experiments show improvements about (1.2 per cent) over standard RNN.
ENDOGENOUS RECOMBINANT GROWTH AND INTELLECTUAL PROPERTY RIGHTS
Authors: Marchese Carla , Marsiglio Simone , Privileggi Fabio , Ramello Giovanni B.
Published: September 2017

We show that, even in a framework in which monopolistic exploitation of patents does not occur, patents still give rise to serious drawbacks. We rely on a recombinant growth framework that provides a stylized but clear description of the formation of knowledge externalities. In our setting a benevolent government buys immediately new patents in a competitive market and releases their contents for free. We show that inefficiencies nevertheless arise and welfare can be improved by correcting the market price through a tax–subsidy scheme. We characterize the (asymptotic) steady-state equilibrium, and some properties of the transitional path. We show that if certain conditions are met, then the economy will converge to its (asymptotic) balanced growth path, and along such a pathgrowth will be independent of the policy parameter; conversely, transition dynamics are affected by the choice of the policy parameter. We then quantitatively analyze the effect of different policy interventions on welfare, and show that stricter tax (weaker appropriability) regimes lead to higher social welfare.
Sustained inhibition of the native language in bilingual language production: A virtual reality approach
Authors: PEETERS DAVID , DIJKSTRA TON
Published: September 2017

Bilinguals often switch languages as a function of the language background of their addressee. The control mechanisms supporting bilinguals' ability to select the contextually appropriate language are heavily debated. Here we present four experiments in which unbalanced bilinguals named pictures in their first language Dutch and their second language English in mixed and blocked contexts. Immersive virtual reality technology was used to increase the ecological validity of the cued language-switching paradigm. Behaviorally, we consistently observed symmetrical switch costs, reversed language dominance, and asymmetrical mixing costs. These findings indicate that unbalanced bilinguals apply sustained inhibition to their dominant L1 in mixed language settings. Consequent enhanced processing costs for the L1 in a mixed versus a blocked context were reflected by a sustained positive component in event-related potentials. Methodologically, the use of virtual reality opens up a wide range of possibilities to study language and communication in bilingual and other communicative settings.
The mismatch between observational measures and residents’ perspectives on the retail food environment: a mixed-methods approach in the Heart Healthy Hoods study
Authors: Díez Julia , Valiente Roberto , Ramos Carmen , García Reyes , Gittelsohn Joel , Franco Manuel
Published: September 2017

Objective

To gain a deeper understanding of the retail food environment by investigating similarities and differences between objective measures and residents’ perspectives.

Design

The study incorporated Geographic Information System (GIS)-based measures, in-store surveys and the results from a larger photovoice project. We combined these data using a convergent parallel mixed-methods approach.

Setting

We conducted this study in a low-income neighbourhood in Madrid (Spain) in 2016.

Subjects

We assessed healthy food availability, accessibility and affordability using GIS-based measures and in-store audits. We also analysed the photographs and discussions from twelve participants who engaged in a photovoice project on their food environment.

Results

Quantitative results depicted a widely served and highly accessible retail food environment, in which supermarkets scored highest in terms of healthy food availability (36·5 out of 39) and 98·9 % of residents could access a healthy food store within a walking travel distance of less than 15 min. Qualitative results showed that participants preferred small local businesses over supermarkets, and revealed built environment obstacles for elderly residents. They also highlighted how the socio-economic context constrained residents’ food choices.

Conclusions

People’s experienced retail food environment is different from the one quantitatively analysed. Results show the potential of using a mixed-methods approach to enrich food environment research and enhance public health interventions.
Well-founded operators for normal hybrid MKNF knowledge bases
Authors: JI JIANMIN , LIU FANGFANG , YOU JIA-HUAI
Published: September 2017

Hybrid MKNF knowledge bases have been considered one of the dominant approaches to combining open world ontology languages with closed world rule-based languages. Currently, the only known inference methods are based on the approach of guess-and-verify, while most modern SAT/ASP solvers are built under the DPLL architecture. The central impediment here is that it is not clear what constitutes a constraint propagator, a key component employed in any DPLL-based solver. In this paper, we address this problem by formulating the notion of unfounded sets for non-disjunctive hybrid MKNF knowledge bases, based on which we propose and study two new well-founded operators. We show that by employing a well-founded operator as a constraint propagator, a sound and complete DPLL search engine can be readily defined. We compare our approach with the operator based on the alternating fixpoint construction by Knorr et al. (2011. Artificial Intelligence 175, 9, 1528–1554) and show that, when applied to arbitrary partial partitions, the new well-founded operators not only propagate more truth values but also circumvent the non-converging behavior of the latter. In addition, we study the possibility of simplifying a given hybrid MKNF knowledge base by employing a well-founded operator and show that, out of the two operators proposed in this paper, the weaker one can be applied for this purpose and the stronger one cannot. These observations are useful in implementing a grounder for hybrid MKNF knowledge bases, which can be applied before the computation of MKNF models.
HISTORY, LAW AND FREEDOM: F. W. MAITLAND IN CONTEXT
Authors: KIRBY JAMES
Published: September 2017

This article considers the intellectual development of the historian and jurist F. W. Maitland (1850–1906). Its focus is the development of his ideas about the importance of intermediate groups between the individual and the state. Maitland expounded these ideas in a dazzling series of late essays which became the wellspring of the tradition known as “political pluralism.” Yet, as this article shows, the same ideas also played a crucial role in Maitland's great works of legal and historical scholarship, includingThe History of English Law. If this is appreciated, then the liberal, Germanist and constitutionalist basis of Maitland's thought becomes clear. So too does Maitland's position as a “new” liberal thinker, committed to freedom and constitutionalism, but critical of individualism and parliamentary sovereignty. In short, it is only if Maitland's political essays are read alongside his works of history and law that either can really be understood.
INSOMNIA AND OTHER CONSTITUTIONAL PATHOLOGIES
Authors: LENOWITZ JEFFREY , SCHWARTZBERG MELISSA
Published: September 2017

The publication of Richard Tuck's 2012 Seeley Lectures constituted an important event in intellectual history and political theory. The Sleeping Sovereign reflects the depth of Tuck's nearly forty years of historical inquiry into the concepts of rights, reason of state, and freedom, beginning with Natural Rights Theories. The leading member of the “Cambridge school” of the study of the history of political thought in the United States, and the Frank G. Thomson Professor of Government at Harvard University, Tuck combines a contextualist, and often intertextualist, approach to the interpretation of canonical works with a theorist's attention to the value these works retain for contemporary political life.
DEMOCRACY AND EXPERTISE IN THE LIPPMANN–TERMAN CONTROVERSY
Authors: ARNOLD-FORSTER TOM
Published: September 2017

Historians often interpret American political thought in the early twentieth century through an opposition between the technocratic power of expertise and the deliberative promise of democracy, respectively represented by Walter Lippmann and John Dewey. This article explores Lippmann's concurrent controversy with Lewis Terman about intelligence testing, in which Dewey also intervened. It argues that the Lippmann–Terman controversy dramatized and developed a range of ideas about the politics of expertise in a democracy, which centered on explaining how democratic citizens might engage with and control the authority of experts. It concludes by examining the controversy's influence on democratic theory.
Bottom-up or top-down? The origins of the Industrial Revolution
Authors: MOKYR JOEL
Published: September 2017

Was technological progress during and after the Industrial Revolution top-down or bottom-up? The technology that created the great inventions was driven by a combination of pathbreaking ideas and the dexterity and skills of trained artisans. While those forms of human capital were quite different, they both came out of small elites of intellectuals and craftsmen, what are rapidly becoming known as “upper-tail human capital.” I analyze the institutions that drove the incentives for both, and show that they came together to produce the Great Enrichment. These incentives were both material and social: between 1500 and 1700, the search for financial security and reputation cooperated in producing a unique institutional environment in which the elites in Western Europe produced the three legged-stool of European modernity: the Reformation, the Scientific Revolution, and the Enlightenment. Once these three movements had succeeded, the foundation for modern economic growth had been laid.
Optimal reinsurance: a reinsurer’s perspective
Authors: Huang Fei , Yu Honglin
Published: September 2017

In this paper, the optimal safety loading that the reinsurer should set in the reinsurance pricing is studied, which is novel in the literature. It is first assumed that the insurer will choose the form of the reinsurance contract by following the results derived in Cai et al. Different optimality criteria from the reinsurer’s perspective are then studied, such as maximising the expectation of the profit, maximising the utility of the profit and minimising the value-at-risk of the reinsurer’s total loss. By applying the concept of comonotonicity, the problem in which the reinsurer is facing two risks with unknown dependency structure is also solved. Closed-form solutions are obtained when the underlying losses are zero-modified exponentially distributed. Finally, numerical examples are provided to illustrate the results derived.
Religious, Political, and Geographical Determinants of Attitudes to Protestant Parades in Northern Ireland
Authors: Evans Jocelyn , Tonge Jonathan
Published: September 2017

Although violence over Northern Ireland's constitutional position has largely subsided, the problem of sectarian animosity between sections of the Protestant Unionist British and Catholic Irish Nationalist population remains. One such area of communal contestation is attitudes to Protestant parades, organized mainly by the Orange Order. For many Protestants, Orange Order marches are legitimate cultural, religious, and political expressions of Protestant culture, loyalty to the British Crown and a pro-United Kingdom position. For many Catholics, the Orange Order is seen as a sectarian and anti-Catholic organization, which prohibits its members marrying Catholics or attending Catholic Church services. The Parades Commission was established two decades ago to adjudicate on Orange Order parading routes. Its decisions have sometimes involved re-routing marches away from Catholic areas and the inability to satisfy both sides has been followed by riots on several occasions at the annual height of the Protestant “marching season.” This article examines levels of support or antipathy toward Orange Order marching rights among Protestants and Catholics. Drawing upon evidence from the most extensive recent study of public opinion in Northern Ireland, the 2015 Economic and Social Research Council general election study, the piece tests the importance of demographic, religious, political, and geographical variables in conditioning attitudes towards Orange parades.
Restrictions on the use of force at sea: An environmental protection perspective
Authors: Ma Jinxing , Sun Shiyan
Published: September 2017

The restrictions on the use of force at sea exist in different branches of international law: the law of the sea and environmental law, mainly applicable during peacetime, and international humanitarian law (IHL), as the law applicable in times of armed conflict. Different rules from these areas must be compared and analyzed to determine the common principles applicable to restricting the use of force at sea for the purposes of environmental protection. Taking into account the particular problems of protecting the marine environment in the context of the use of force, the law of the sea and international environmental law should be applied to restrict means and methods of using force at sea during armed conflict. The detailed concepts and approaches in the law of the sea and environmental law may complement IHL, and the precautionary principle of international environmental law should be triggered to address the lacunae in IHL protecting the marine environmental during armed conflict.
The Relationship Between Use of Social Network Sites, Online Social	Support, and Well-Being
Authors: Utz Sonja , Breuer Johannes
Published: September 2017

Abstract. Existing work on the effects of social network sites (SNS) on well-being has often stressed that SNS can help people gain social support from their online networks, which positively affects their well-being. However, the majority of studies in this area have been cross-sectional in nature and/or relied on student samples. Using data from six waves of a longitudinal study with a representative sample of Dutch Internet users, we first examined whether users and nonusers of SNS differ in online social support and well-being (as indicated by life satisfaction and stress). In a second step, we investigated in more detail how SNS use – more specifically, asking for advice and the number of strong ties on these SNS – are related to online social support, stress, and satisfaction with life. Overall, our results provide no evidence for SNS use and online social support affecting either stress or life satisfaction. SNS users reported more online social support than nonusers did, but also higher levels of stress; the two groups did not differ in overall life satisfaction. With regard to the underlying processes, we found positive cross-sectional and longitudinal relationships between asking for advice on SNS and online social support, indicating that SNS can be an effective tool for receiving social support. However, online social support was not related to higher life satisfaction or reduced stress 6 months later; instead, it seems that SNS users with lower life satisfaction and/or higher stress seek more social support online by asking for advice on SNS.
Mindful Instant Messaging
Authors: Bauer Arne A. , Loy Laura S. , Masur Philipp K. , Schneider Frank M.
Published: September 2017

Abstract. The number of smartphone users surpassed two billion in 2016; the most popular applications are instant messengers. However, research about benefits and risks for users has yielded contradictory findings and indicates that the relation between smartphone use and well-being depends on many conditions. We propose mindfulness as a predictor of well-being related to instant messaging. In our study, 211 participants answered short questionnaires on the evenings of five consecutive days. Multilevel analyses showed that a mindful use of instant messaging was positively related to users’ well-being, as indicated by more positive affect and less stress related to instant messaging. Moreover, the relation between day-specific mindfulness and well-being was statistically mediated by a more autonomous motivation to use instant messengers.
The Experience of Mobile Entrapment in Daily Life
Authors: Hall Jeffrey
Published: September 2017

Abstract. This multistudy investigation examines how entrapment, which is the guilt, anxiety, or stress to respond and be available to others via mobile devices, shapes and is shaped by patterns of mobile use. Using structural equation modeling on cross-sectional survey responses, Study 1 (N = 300) tested relationships among offline social network size, voice and text frequency, entrapment, and well-being. Offline social network size was associated with text message frequency, and both were indirectly associated with lower subjective well-being via entrapment. Study 2 used experience sampling to confirm associations among entrapment, texting, and well-being. Participants (N = 112) reported on face-to-face, phone, and text interactions five times a day for 5 consecutive days (n = 1,879). Multilevel modeling results indicated that beginning-of-week entrapment was associated with more interactions with acquaintances and strangers, and with reporting lower affective well-being and relatedness when interacting via text. Well-being reported during text interactions and number of interactions with acquaintances and strangers during the week both predicted changes in entrapment by the week’s end. Change in entrapment was associated with lower subjective well-being at the week’s end. Results suggest that entrapment is associated with using texting to maintain larger networks of social relationships, potentially stressing individuals’ capacity to maintain less close relationships via mobile communication.
Nucleolar and coiled-body phosphoprotein 1 (NOLC1) regulates the nucleolar retention of TRF2
Authors: Yuan Fuwen , Li Guodong , Tong Tanjun
Published: September 2017

Telomeric repeat-binding factor 2 (TRF2) was reported to localize in the nucleolus of human cells in a cell cycle-dependent manner; however, the underlying mechanism remains unclear. Here, we found that nucleolar and coiled-body phosphoprotein 1 (NOLC1) interacted with TRF2 and mediated the shuttling of TRF2 between the nucleolus and nucleus in human 293T and HepG2 cells. Ablation of NOLC1 expression increased the number of nuclear TRF2 foci and decreased the nucleolar level of TRF2. Conversely, NOLC1 overexpression promoted the nucleolar accumulation of TRF2. NOLC1 overexpression also increased the number of 53BP1 foci and induced the DNA damage response. In addition, co-expression of TRF2 rescued NOLC1 overexpression-induced cell cycle arrest and apoptosis.
BRCA1 regulation on β-hCG: a mechanism for tumorigenicity in BRCA1 defective breast cancer
Authors: Sengodan S K , Nadhan R , Nair R S , Hemalatha S K , Somasundaram V , Sushama R R , Rajan A , Latha N R , Varghese G R , Thankappan R k , Kumar J M , Chil A , Anilkumar T V , Srinivas P
Published: September 2017

Human chorionic gonadotropin β (β-hCG) has been implicated in breast tumorigenesis. However, the role of this hormone is highly controversial as certain studies suggest it has anti-tumor properties while others have found it to be pro-tumorigenic. To unveil the truth, we have analyzed the expression of β-hCG in breast cancer. We identified for the first time that β-hCG expression is linked to BRCA1 status and its overexpression is seen in BRCA1 mutated breast cancer cells, BRCA1 conditional knockout mouse breast cancer tissues and BRCA1 floxed basal cell carcinoma (BCC) tissues. An analysis of three large, transcriptomic data sets from TCGA (The Cancer Genome Atlas) expression profile confirmed the inverse correlation between BRCA1 and β-hCG in human breast cancer. Using ChIP and luciferase assays, we also demonstrated that the cancer cells with wild-type but not mutant BRCA1 directly repress the expression of β-hCG by binding to its promoter. Further, β-hCG promotes migration and invasion predominantly in BRCA1 mutant breast cancer cells. Interestingly, stable overexpression of β-hCG in BRCA1 mutant but not wild-type breast cancer cells results in the formation of spheres even on monolayer cultures. The cells of these spheres show high expression of both EMT and stem cell markers. Since β-hCG belongs to a cysteine knot family of proteins like TGFβ and TGFβ signaling is deregulated in BRCA1 defective tumors, we checked whether β-hCG can mediate signaling through TGFβRII in BRCA1 mutated cells. We found for the first time that β-hCG can bind and phosphorylate TGFβRII, irrespective of LHCGR status and induce proliferation in BRCA1 defective cells. Our results confirmed that there exists a transcriptional regulation of BRCA1 on β-hCG and BRCA1 mutation promotes β-hCG mediated tumorigenesis through TGFβRII signaling. Thus inhibiting β-hCG-TGFβRII could prove an effective treatment strategy for BRCA1 mutated tumors.
interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration
Authors: Tsujioka Hiroshi , Kunieda Takekazu , Katou Yuki , Shirahige Katsuhiko , Fukazawa Taro , Kubo Takeo
Published: September 2017

Unlike mammals,Xenopus laevistadpoles possess high ability to regenerate their lost organs. In amphibians, the main source of regenerated tissues is lineage-restricted tissue stem cells, but the mechanisms underlying induction, maintenance and differentiation of these stem/progenitor cells in the regenerating organs are poorly understood. We previously reported thatinterleukin-11(il-11) is highly expressed in the proliferating cells of regeneratingXenopustadpole tails. Here, we show thatil-11knockdown (KD) shortens the regenerated tail length, and the phenotype is rescued by forced-il-11-expression in the KD tadpoles. Moreover, marker genes for undifferentiated notochord, muscle, and sensory neurons are downregulated in the KD tadpoles, and the forced-il-11-expression in intact tadpole tails induces expression of these marker genes. Our findings demonstrate thatil-11is necessary for organ regeneration, and suggest that IL-11 plays a key role in the induction and maintenance of undifferentiated progenitors across cell lineages duringXenopustail regeneration.
HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
Authors: Cesana Daniela , Santoni de Sio Francesca R. , Rudilosso Laura , Gallina Pierangela , Calabria Andrea , Beretta Stefano , Merelli Ivan , Bruzzesi Elena , Passerini Laura , Nozza Silvia , Vicenzi Elisa , Poli Guido , Gregori Silvia , Tambussi Giuseppe , Montini Eugenio
Published: September 2017

HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell clones. Here, we show that in 30/87 (34%) patients under combination antiretroviral therapy, BACH2, and STAT5B are activated by insertions triggering the formation of mRNAs that contain viral sequences fused by splicing to their first protein-coding exon. These chimeric mRNAs, predicted to express full-length proteins, are enriched in T regulatory and T central memory cells, but not in other T lymphocyte subsets or monocytes. Overexpression of BACH2 or STAT5B in primary T regulatory cells increases their proliferation and survival without compromising their function. Hence, we provide evidence that HIV-1-mediated insertional activation of BACH2 and STAT5B favor the persistence of a viral reservoir in T regulatory cells in patients under combination antiretroviral therapy.
The WISDOM Study: breaking the deadlock in the breast cancer screening debate
Authors: Esserman Laura J. ,   the WISDOM Study and Athena Investigators, Anton-Culver Hoda , Borowsky Alexander , Brain Susie , Cink Thomas , Crawford Beth , Eklund Martin , Esserman Laura , Fenton Joshua , Heditsian Diane , Hiatt Robert A. , Hogarth Michael , Kaplan Celia , Koenig Barbara , LaCroix Andrea , Larsen Kathryn M. , Lee Vivian , Matthews Jeffrey , Madlensky Lisa , Naeim Arash , Ojeda-Fournier Haydee , Parker Barbara A. , Sepucha Karen , Shieh Yiwey , Stover Fiscalini Allison , Thompson Carlie , Tice Jeffrey , Van ‘T Veer Laura , Wenger Neil , Ziv Elad
Published: September 2017

There are few medical issues that have generated as much controversy as screening for breast cancer. In science, controversy often stimulates innovation; however, the intensely divisive debate over mammographic screening has had the opposite effect and has stifled progress. The same two questions—whether it is better to screen annually or bi-annually, and whether women are best served by beginning screening at 40 or some later age—have been debated for 20 years, based on data generated three to four decades ago. The controversy has continued largely because our current approach to screening assumes all women have the same risk for the same type of breast cancer. In fact, we now know that cancers vary tremendously in terms of timing of onset, rate of growth, and probability of metastasis. In an era of personalized medicine, we have the opportunity to investigate tailored screening based on a woman’s specific risk for a specific tumor type, generating new data that can inform best practices rather than to continue the rancorous debate. It is time to move from debate to wisdom by asking new questions and generating new knowledge. The WISDOM Study (Women Informed to Screen Depending On Measures of risk) is a pragmatic, adaptive, randomized clinical trial comparing a comprehensive risk-based, or personalized approach to traditional annual breast cancer screening. The multicenter trial will enroll 100,000 women, powered for a primary endpoint of non-inferiority with respect to the number of late stage cancers detected. The trial will determine whether screening based on personalized risk is as safe, less morbid, preferred by women, will facilitate prevention for those most likely to benefit, and adapt as we learn who is at risk for what kind of cancer. Funded by the Patient Centered Outcomes Research Institute, WISDOM is the product of a multi-year stakeholder engagement process that has brought together consumers, advocates, primary care physicians, specialists, policy makers, technology companies and payers to help break the deadlock in this debate and advance towards a new, dynamic approach to breast cancer screening.