bluuebunny/crossref_metadata_2025 huggingface dataset:
A Mixed-Method National Study of Public Health Core Competencies in Undergraduate Medical Schools in Thailand to Find out the Need for Transformative Changes
Authors: Aung Myo Nyein , Vanapruks Vanich , Sithisarankul Pornchai , Yenbutra Pajaree , Rattanamongkolgul Suthee , Suvarnabhumi Krishna , Wannakrairot Pongsak
Published: May 2022

Background: With new challenges to the health system, many new competencies within the scope of teaching public health need to be addressed in medical schools’ curricula such as disaster risk management and health system science. The aims of this study were to identify the needs of public health competencies for medical doctors in Thailand and to assess the level of integration for technical collaboration in teaching public health. Method: A total of 17 out of 21 Thai medical schools participated in the national survey. Qualitative inquiries applied focus group interviews of community representatives from ten sample villages and in-depth interviews of representatives from stakeholder organizations particularly employers. The list of public health competencies framework recommended by WHO-SEARO was applied. Quantitative analysis applied descriptive analysis using STATA 15 and qualitative findings were validated by interrelating the meaning of themes from Word Clouds created in NVivo12. Data integration applied a mixed-method Quan-qual approach. Results: 17 medical schools returned the questionnaires (80.95 % yield). The most common regionally-defined public health competencies (in over 70% of schools) were shown to be: Biostatistics, Community Medicine, Epidemiology, Family Medicine, Medical Ethics and Professional Laws, Preventive Medicine, Health Promotion, Holistic Care, and Research. The curriculum in only one medical school lacked Health Economics, whilst Disaster Management was lacking in two other schools. Discipline-based subjects were found to be more prevalent than interdisciplinary competencies. A variety of methods were being applied for teaching public health. The majority of the schools applied lecture as the main teaching method and multiple-choice questions as the main assessment method. Thai communities expect the doctors to get in touch with the community more often, lead the primary health care team through training the health professionals and community health volunteers, and educate the community for better health. Conclusion: Human resource is the main challenge in addressing interdisciplinary competencies. It is necessary to establish a collaborating mechanism among the big and small medical schools and the faculties of public health to improve the teaching of public health to undergraduate students in medical schools. There is also a need to strengthen the health system science and leadership so that future MDs can lead health service delivery according to the needs of their employers such as the Ministry of Public Health and the Rural Doctors Association. The findings of this study may help to identify a national framework of public health core competencies for medical schools and create a common platform for interdisciplinary collaborations.
PERANCANGAN DATA WAREHOUSE dan DASHBOARD PT XYZ
Authors: I Dewa Bagus Gde Khrisna Jayanta Nugraha  , Susanto Agus , Suganda Girsang Abba
Published: May 2022

Kontraktor adalah perusahaan yang melakukan kontrak kerja dengan orang atau pemerintah atau perusahaan lain untuk memasok barang atau menyelesaikan jasa tertentu. PT. XYZ memiliki data kontrak proyek yang sangat banyak dan masih belum diolah menjadi suatu informasi. Untuk memudahkan karyawan PT. XYZ dalam menganalisa dan mengevaluasi project-project yang sudah berlalu ataupun yang akan datang dibutuhkan Data Warehouse. Tujuan dari penelitian ini adalah merancang dan menganalisa data warehouse yang dibutuhkan dalam penyediaan informasi mengenai data kontrak project pada PT. XYZ. metode perancangan data warehouse menggunakan 4 tahapan (Four-Step Methodology) yang diusulkan oleh Ralph Kimball dalam merancang sistem data warehouse. Hasil akhir yang akan dicapai adalah perancangan data warehouse dan dashboard adalah visualisasi yang akan menyediakan informasi signifikan mengenai data kontrak project pada PT.XYZ yang dapat dilihat dari sudut pandang berbeda dan memudahkan pihak terkait dalam pengambilan keputusan.
Prototype Kacamata Sensorik Untuk Tunanetra Berbasis Mikrokontroler
Authors: Hendryadi Dedy , Iryani Juniarti , Azran M
Published: May 2022

The final goal to be achieved: A microcontroller-based object detection glasses that can be used by the visually impaired, as a tool to detect objects in front of them when walking. This research uses the action research method (Action Research) is an effort to try out ideas into practice to improve or change something in order to have a real impact. Based on the results of the research, it can be concluded that: (1) In this study, we produce a tool for the visually impaired with an ultrasonic sensor in the form of glasses that use Arduino Pro Mini as a microcontroller and have the ability to detect an object in front of it to make it easier for blind people to walk. (2) These sensory glasses are able to provide a sound warning to the user when they find an object in front of them at a distance of less than 100 cm.
PENDETEKSI PEMAKAIAN MASKER MENGGUNAKAN WEBCAM SEBAGAI ALTERNATIF PENCEGAHAN COVID-19 DI INSTITUT TEKNOLOGI PADANG
Authors: Busran Busran
Published: May 2022

Pemakaian masker disaat pandemi COVID-19 merupakan hal yang menjadi syarat dalam protokol kesehatan seseorang jika igin bepergian keluar rumah, seperti ke kantor,  kampus dan ketempat keramaian lainnya. Dengan menggunakan masker dapat menggurangi penyebaran COVID-19. Di Institut Teknologi Padang, pendeteksian pemakaian masker dilakukan secara manual oleh petugas keamanan sewaktu memasuki kampus.  Tujuan dari penelitian ini untuk mengimplementasikan pendeteksian wajah dalam penggunaan masker untuk keperluan protokol kesehatan. Pendeteksian masker dilakukan dengan kamera. Dalam penggambilan wajah menggunakan kamera dilakukan secara real time. Gambar yang diambil akan dikonversikan ke grayscale tujuannya menghindari bit-bit yang tidak diperlukan. Setelah didapatkan grayscale selanjutnya grayscale ini dikonversikan menjadi bentuk data. Data yang didapatkan akan dicocokan dengan data yang ada pada harcascade wajah. Apabila data harcascade wajah sama dengan data yang sudah dikonversikan dari grayscale tadi maka dianggap wilayah tersebut ada wajah. Adanya wajah, maka dilanjutkan pada bagian hidung, data yang didapat akan dicocokan dengan harcascade hidung. Apabila hidung tertutup maka dianggap menggunakan masker. Sebaliknya hidung terdeteksi maka tidak menggunakan masker. Penelitian ini membuat prototype alat yang bekerja dalam mendeteksi masker sesuai syarat protokol kesehatan.
The Influence of Pore Structure of the Core-Scale Fracture-Controlled Matrix Unit on Imbibition: Model Construction and Definition of the Fractal Coefficient
Authors: Liu Qiang , Liu Jianjun , Liang Bing , Sun Weiji , He Jie , Lei Yun
Published: May 2022

Imbibition oil recovery plays an important role in the development of low-permeability fractured reservoirs. However, the effects of the complex pore structure of the matrix on imbibition have not been considered comprehensively at different scales in the scientific literature. This paper reports a study of the mechanisms of influence of different matrix pores on imbibition recovery ratio and defines the concept of a fractal coefficient using the method of combining numerical simulation at the core scale with mathematical methods at a pore scale. A matrix model with different pore fractal dimensions and tortuosity of the capillary was established using Python language programming. Y-type and S-type were used to characterize the fractures, and a two-dimensional fracture-controlled matrix unit core-scale numerical model with complex pore structures was established. Based on phase field theory, an oil-water two-phase imbibition numerical simulation was conducted. Comparisons of numerical simulation results and microscopic analysis indicated that imbibition recovery ratio was 39.28% and 50.94%, respectively. The imbibition law revealed by the numerical simulation results is consistent with the results of the microscopic imbibition experiment, and the imbibition effect of bifurcated fractures was better than that of simple curved fractures. As the pore fractal dimension and tortuosity of the capillary increased, the imbibition recovery ratio decreased. A comparison of results of the mathematical model demonstrated that there was a difference between the pore scale and core scale because the pore fractal dimension and capillary tortuosity changed dynamically with pore structure at the core scale. Thus, a parameter that characterizes the relative change of pore fractal dimension and tortuosity was defined and called the fractal coefficient. When the skeleton particles are 200, 400, and 500, the fractal coefficient were calculated to be 0.625 and 0.6, respectively, indicating that when the pore structure changes, the imbibition recovery ratio should be dominated by capillary tortuosity.
Multifunctional Biosurfactants with Unusual pH Sensitive Interfacial Behavior for Remediation of Iron and Zinc Sulfide Formation Damage
Authors: Yong Hin Cheong Au , Tooker Kortney , Pham Khanh Van , Arriaga Richard , Mahmoudkhani Amir
Published: May 2022

Metal sulfide scales are found in several fields in onshore and offshore oil and gas wells around the world. Although there has been some success in the development of sulfide scale inhibitors, significantly high concentration of inhibitor is often required specially to mitigate zinc sulfide. Microbial biosurfactants have an inherent affinity towards different mineral surfaces including sulfides. The unique surface and interfacial properties of these naturally derived products make them potential candidates for development of new products for metal sulfide scale management and control. In this work the properties of sophorolipids and rhamnolipids as dispersion and modification agents for iron and zinc sulfide precipitates were investigated. Surface and interfacial tension behaviors of microbial biosurfactants were measured using a drop shape tensiometer. Accelerated dispersion stability testing were used to determine the efficiency of biosurfactants for dispersing field collected and lab-made iron and zinc sulfides. Fourier transform – infrared (FTIR) and ultraviolet – visible (UV-vis) spectroscopy was used to determine the mode of interaction of the biosurfactant active sites with metal sulfide surfaces.
The CHALLENGE-trial: the effects of a virtual reality-assisted exposure therapy for persistent auditory hallucinations versus supportive counselling in people with psychosis: study protocol for a randomised clinical trial.
Authors: Smith Lisa Charlotte , Mariegaard Lise , Vernal Ditte Lammers , Christensen Annette Gosvig , Albert Nikolai , Thomas Neil , Hjorthøj Carsten , Glenthøj Louise Birkedal , Nordentoft Merete
Published: May 2022

Background: Many patients suffering from schizophrenia spectrum disorders continue having distressing auditory hallucinations in spite of treatment with antipsychotic medication. The aim of this trial is to examine the effect of a targeted virtual reality therapy for persistent auditory hallucinations in individuals with psychosis. The trial explores whether this type of therapy can decrease the severity, frequency, and distress of auditory hallucinations and additionally, whether it can reduce clinical symptoms and enhance daily functioning in individuals with psychosis. Methods: The study is a randomised, assessor-blinded parallel-groups superiority clinical trial, allocating a total of 266 patients to either the experimental intervention or supportive counselling. The participants will be randomised to either 1) seven sessions of virtual reality therapy or 2) seven sessions of supportive counselling to be delivered within the first 12 weeks after inclusion in the study. All participants will be assessed at baseline and 12- and 24 weeks post baseline. Independent assessors blinded to treatment allocation will evaluate outcome. The primary outcome is the level of auditory hallucinations measured with The Psychotic Symptoms Rating Scales (PSYRATS-AH) total score at cessation of treatment at 12-weeks. Secondary outcomes are frequency of auditory hallucinations, the distress caused by auditory hallucinations, perceived voice power, patient acceptance of voices, patients’ ability to respond to voices in an assertive way and social and daily function. Discussion: Promising evidence exist of the efficacy of this immersive virtual reality-based therapy for auditory hallucinations, but evidence needs to be established in a large, methodological rigorous trial. If the therapy proves to be beneficial in reducing the severity of refractory auditory hallucinations, a large group of patients with schizophrenia and related disorders could be the target group of this short-term psychotherapeutic intervention.
A method to replace NaCl as a flotation solution for extracting MPs in soil: A case study of the Jiaxing agricultural soil from China
Authors: Liu Yi , Lin Yimiao , Xie Jiafei , Li Penghao , Wang Kewei , Zhou Ying , Wang Pingya , Wu Yichun
Published: May 2022

Microplastics (MPs) have become an important global issue in recent years. However, MPs in the soil have received far less attention than those in water. Effective and nondestructive extraction of MPs is important for studying MPs in agricultural soils. This study uses different floatation solutions as experiments and uses MgCl 2 as the floatation solution of the density extraction method. This method can quickly and comprehensively extract MPs in agricultural soil, and is inexpensive and nontoxic. Five types of standard MPs (PE, PP, PS, PVC and PET) are used as the objects of this experiment, and each have two different particle sizes (3 mm and 0.075 mm). The accuracy and precision of the method were verified using standard addition and recovery. The recovery of the two particle sizes was between 90.82% and 109.69%. The extracted standard MPs were then subjected to IR and Raman spectroscopic analysis, and the results showed that Raman spectroscopy was more suitable for the identification of the extracted MPs. Finally, this method collected and verified a vast number of soil samples and further analyzed the abundance and characteristics of the collected MPs. The results show that the use of MgCl 2 as the floatation solution of the density extraction method to extract MPs from the soil may be an alternative to the current NaCl method.
Long-term exercise training down-regulates m6A RNA demethylase FTO expression in the hippocampus and hypothalamus: An effective intervention for epigenetic modification
Authors: Liu Shu-Jing , Cai Tong-Hui , Fang Chun-Lu , Lin Shao-Zhang , Yang Wen-Qi , Wei Yuan , Zhou Fu , Liu Ling , Luo Yuan , Guo Zhi-Yi , Zhao Ge , Li Ya-Ping , Li Liang-Ming
Published: May 2022

Background
Exercise boosts the health of some brain parts, such as the hippocampus and hypothalamus. Several studies show that long-term exercise improves spatial learning and memory, enhances hypothalamic leptin sensitivity, and regulates energy balance. However, the effect of exercise on the hippocampus and hypothalamus is not fully understood. The study aimed to find epigenetic modifications or changes in gene expression of the hippocampus and hypothalamus due to exercise.
Methods
Male C57BL/6 mice were randomly divided into sedentary and exercise groups. All mice in the exercise group were subjected to treadmill exercise 5 days per week for 1 h each day. After the 12-week exercise intervention, the hippocampus and hypothalamus tissue were used for RNA-sequencing or molecular biology experiments.
Results
In both groups, numerous differentially expressed genes of the hippocampus (up-regulated: 53, down-regulated:49) and hypothalamus (up-regulated:24, down-regulated:40) were observed. In the exercise group, increased level of N6-methyladenosine (m6A) was observed in the hippocampus and hypothalamus (p < 0.05). Furthermore, the fat mass and obesity-associated gene (FTO) of the hippocampus and hypothalamus were down-regulated in the exercise group (p < 0.001). In addition, the Fto co-expression genes of the mouse brain were studied and analyzed using database to detemine the potential roles of exercise-downregulated FTO in the brain.
Conclusion
The findings demonstrate that long-term exercise might elevates the levels of m6A-tagged transcripts in the hippocampus and hypothalamus via down-regulation of FTO. Hence, exercise might be an effective intervention for epigenetic modification.
Mechanism of zinc alleviating cadmium toxicity in mangrove plant (Kandelia obovata)
Authors: Shan Chen
Published: May 2022

Cadmium pollution is very common in mangrove ecosystem in China, and the pollution situation is serious. Zinc has been used to reduce cadmium accumulation in soil and plants, and phenolic acid metabolism plays an important role in plant response to stress. Therefore, the aim of this study was to clarify whether zinc alleviates cadmium toxicity in mangrove plants through phenolic acid metabolism. The cadmium contaminated Kandelia obovata was treated with different concentrations of (80,300,400mg/kg) ZnSO4 in pot experiment. The results showed that the cadmium content and zinc content of Kandelia obovata in its leaves were in the range of 0.077 ~ 0.197mg kg− 1 dw and 90.260 ~ 114.447 mg kg− 1 dw under different zinc treatment concentrations. The synthesis of phenolic acid metabolites such as 4-hydroxy benzoic acid, chlorogenic acid and cinnamic acid increased. Low dose zinc sulfate treatment had significant positive effects on the biomass, phenolic acid metabolization-related enzyme activities, antioxidant capacity, chlorophyll and soluble sugar contents of cadmium-contaminated mangrove plants. The results showed that low dose of Zn could enhance the metabolism of phenolic acid and synthesize more phenolic compounds such as hydroxycinnamic acid and hydroxybenzoic acid to increase the antioxidant capacity of mangrove plants.
The Study on Water-richness of Thin Limestone Aquifers in North China Coalfields
Authors: Lv Situ , Zhang Longqiang
Published: May 2022

To obtain the evaluation results that are more in line with the water-richness of thin limestone aquifers for ensuring the safety of coal mine production, dewatering test and hydrochemical analysis were conducted on Benxi thin limestone aquifer to explore and quantify the hydraulic connection between the Ordovician limestone aquifer and the thin limestone aquifer in Benxi formation. Based on the characteristics of water-bearing media, such as aquifer thickness, core recovery, flushing fluid consumption and permeability coefficient, the CRITIC weighting method was used to determine the weight of each factor’s influence on the water-richness of thin limestone aquifers, so as to establish the model for evaluating the water-richness of thin limestone aquifer in Benxi formation, and draw the thematic map of the main controlling factors of the aquifers. Then, the information was normalized and superimposed using the multi-source information fusion technology, thereby obtaining the zoning of the aquifer per different water-richness. The evaluation results show that the thin limestone aquifer in Benxi formation can be divided into five areas, i.e. “strong, relatively strong, medium weak, relatively weak and weak ” areas. With a stronger hydraulic connection with the Ordovician limestone aquifer, the northwest part of the research area has a greater water-richness than the southeast part, which was verified by the pumping test carried out in the study area.
Intrusion Detection System: A Comparative Study of Machine Learning-based IDS
Authors: Singh Amit , Prakash Jay , Kumar Gaurav
Published: May 2022

Due to the Covid-19 pandemic, there has been a significant rise in the amount of data processed and transferred to any communication network. The use of encrypted data, the diversity of new protocols, and the surge in the number of malicious activities worldwide have posed new challenges for Intrusion Detection Systems (IDS). In this scenario, existing signature-based IDS are not performing well. Various researchers have proposed machine learning-based IDS to detect unknown malicious activities based on behaviour patterns. Results have shown that machine learning-based IDS perform better than signature-based IDS (SIDS) in identifying new malicious activities in the communication network. In this paper, we have analyzed the IDS dataset that contains the most current common attacks and evaluated the performance of network intrusion detection systems by adopting two data resampling techniques and ten machine learning classifiers. It has been observed that the top three IDS models KNeighbors, XGBoost and AdaBoost outperform in binary-class classification with 99.49%, 99.14% and 98.75% accuracy, and XGBoost, KNneighbors, and GaussianNB outperform in multi-class classification with 99.30%, 98.88% and 96.66% accuracy, respectively.
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo/YAP pathway
Authors: Wang Lijun , Wang Lihui , Wang Rongli , Xu Ting , Wang Jingyuan , Cui Zhiwei , Cheng Feiyan , Wang Wei , Yang Xinyuan
Published: May 2022

Background
Stem cells have been documented as a new therapeutic method for ovarian injuries such as premature ovarian failure (POF). However, effects of exosomes (Exos) derived from human endometrial stem cells (EnSCs) on diminished ovarian failure remain to be carefully elucidated. Therefore, our study aims to investigate the mechanisms of EnSC-Exos is related to Hippo signal pathway in the recovery of the cisplatin-induced granulosa cell injury model in vitro and the POF mice model in vivo.
Methods
Exosomes derived from human EnSCs were isolated by ultracentrifugation and identified by electron microscopy and western blot (WB) analysis, stained by PKH26, respectively. The mechanism involving suppression of Hippo signaling pathway and activation of Yes-associated protein (YAP) was investigated for evaluating EnSC-Exos therapeutic effects in the cisplatin-induced granulosa cell injury model in vitro using flow cytometry, WB, qRT-PCR, immunofluorescence and EdU staining. Hematoxylin-eosin staining, ELISA and immunohistochemistry analysis were used for evaluating EnSC-Exos therapeutic effects in POF mice model.
Results
We established successful construction of the cisplatin-induced granulosa cell injury model and evaluated Hippo signaling pathway activation in cisplatin-damaged granulosa cells (GCs). Furthermore, laser scanning confocal microscope and immunofluorescence demonstrated that EnSC-Exos can be transferred to cisplatin-damaged GCs to decrease apoptosis. In addition, the enhanced expression of YAP at the protein level as well as YAP/TEAD target genes, such as CTGF, ANKRD1, and the increase of YAP into the nucleus in immunofluorescence staining after the addition of EnSC-Exos to cisplatin-damaged GCs confirmed the suppression of Hippo signaling, While in vivo, EnSC-Exos successfully remedied POF in mice.
Conclusions
Collectively, our findings suggest that human EnSC-Exos is effective in recovery of ovarian function by chemotherapy-induced POF via activating YAP and inhibiting the Hippo signaling pathway. These findings provide new insights for further understanding of EnSC-Exos in the recovery of ovary function.
Outcomes of combined open-door laminoplasty with bilateral lateral mass screw fixation for traumatic unstable multilevel cervical stenosis: A retrospective case study
Authors: Liu Guanyi , Hu Lihua , Gu Yongjie , Ma Weihu
Published: May 2022

Background
The purpose of this study was to report the outcomes of combined open-door laminoplasty with bilateral lateral mass screw fixation for traumatic unstable multilevel cervical stenosis.
Methods
Data from 11 patients who underwent combined open-door laminoplasty with bilateral lateral mass screw fixation for multilevel cervical stenosis with traumatic cervical instability and spinal cord injury between July 2016 and January 2020 were retrospectively reviewed. Patients treated via the anterior approach and those who did not undergo open-door laminoplasty were excluded. Neurological functional recovery was evaluated using the pre- and postoperative Japanese Orthopaedic Association (JOA) scores and Nurick scores.
Results
All patients underwent operative treatment without neurovascular complications. The average duration of follow-up was 26 months (range, 24 to 30 months). The mean JOA score improved from 5.0 ± 2.68 preoperatively to 12.54 ± 4.39 at final follow-up, and the mean JOA recovery rate was 61.5%. The mean Nurick disability score decreased from 3.27 ± 1.42 preoperatively to 1.45 ± 1.21 at final follow-up. Significant neurogenic recovery was indicated by both the JOA score (t=-4.86, p = 0.000) and the Nurick disability score (t = 3.22, p = 0.009). All patients achieved bone union of cervical fractures and fusion at an average of 3.5 weeks postoperatively (range, 12–16 weeks). No patient had segmental instability, laminar collapse, or internal fixation failure on postoperative radiographs.
Conclusion
Our findings suggest that combined open-door laminoplasty with lateral mass screw fixation achieves satisfactory cervical function in select patients with traumatic unstable multilevel cervical stenosis and spinal cord injury.
Voter Mobilization and the COVID-19 Pandemic: Overcoming Barriers to Voter Engagement during the 2020 Election Season in St. Louis
Authors: Parker Gary
Published: May 2022

Voters in St. Louis, Missouri faced unprecedented challenges amid two critical elections during the 2020 election season. Voters were to determine if the state should opt-in to the Affordable Care Act as well as decide the next President of the United States. With the emergence of the COVID-19 pandemic, mobilizers faces new hurdles to traditional organizing. Public health mandates calling for stay-at-home orders prohibited large public gatherings and in turn, limited access to voters. The response by the State of Missouri to the COVID-19 pandemic was to introduce new voting policies and rules, which caused confusion among voters. Any increase in the administrative burdens creates new barriers voting. As a result, citizens needed to have procedural efficacy, the ability to know how to engage in the democratic process. Semi-structured interviews were conducted with 28 participants, who engaged in voter mobilization within low-income, poverty-impacted communities in St. Louis City and St. Louis County. Subjects identified how they shifted tactics to allow for the health and safety of mobilizers and potential voters. Additionally, policies were identified that would eliminate administrative hurdles placed on voters and shift the burden of facilitating democratic elections to the State. Findings from this study highlight the widening structural barriers and administrative burdens that are inhibiting a straightforward process for engaging in the democratic process of voting and potential policy solutions.
Chronic non-bacterial osteomyelitis in children: Presentation, diagnosis, outcomes, quality of life
Authors: Tekin Zahide Ekici , Gülleroğlu Nadide Başak , Çelikel Elif , Aydın Fatma , Kurt Tuba , Tekgöz Nilüfer , Sezer Müge , Karagöl Cüneyt , Coşkun Serkan , Kaplan Melike Mehveş , Ekşioğlu Ayşe Secil , Acar Banu Çelikel
Published: May 2022

PurposeChronic non-bacterial osteomyelitis is a chronic sterile inflammatory condition of the bone. We aimed to describe the clinical and radiographic findings of patients and to evaluate their response to therapy and quality of life. MethodsThis cross-sectional study included 18 patients whose clinical, radiological features and outcomes were reviewed retrospectively. The quality of patients’ life after treatment was compared to healthy controls by using the Pediatric Quality of Life Inventory 4.0. ResultsThe median age of disease onset was 12 (IQR 10-14) years and 11 (61.1%) patients were male. The median follow-up duration was 15 (IQR 12-22) months. The persistent form of chronic non-bacterial osteomyelitis was the most common pattern in 15 (83.3%) patients and a recurrent pattern was defined in 3 (16.7%) patients. The lesions were multifocal in all patients and 15 (83.3%) patients had symmetric distribution in whole-body magnetic resonance imaging. The most common sites of arthritis were the knee and sacroiliac joints. Methotrexate was used in 16 (88.9%) patients as first-line therapy. However, some patients were unresponsive to first-line therapy and needed tumor necrosis factor-α inhibitors (55.6%) and bisphosphonates (16.7%). We observed remission in only 4 (22.2%) patients and 3 (16.7%) patients were unresponsive. The patients had a significantly poorer quality of life than controls (p=0.005).ConclusionsChronic non-bacterial osteomyelitis is an insidious disease that requires detailed analysis for diagnosis and whole-body magnetic resonance imaging is an effective tool for diagnosis. Despite the advanced treatment, patients with chronic non-bacterial osteomyelitis have a poor quality of life.
Application of Factorial and Binomial identities in Computing and Cybersecurity
Authors: Annamalai Chinnaraji
Published: May 2022

This paper focuses on the application of factorial and binomial identities in computing, communication, and cybersecurity in connection with the symmetric and asymmetric encryptions. We can use the binomial identities and theorem in factorials as an effective security algorithm to protect the computing systems, programs, and networks. In this connection, binomial expansions which are equal to multiples of 2 with non-negative exponents, and its relations are given in this article.
A Shift Toward Activated Receptors and Enhanced Effector Functions on NK Cells Contribute to Immune Imbalance During Sepsis
Authors: He Wanxue , Zhang Lin , Luo Zhiming , Xu Jianqiao , Guan Wei , Xie Lixin
Published: May 2022

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. It is a disease with a high incidence and mortality rate, which has a tremendous impact on global health and social economy. Remarkably, immune imbalance has been recognized as a key pathophysiological change in sepsis, and NK cells, one of the most important innate immune cells, are involved in this process and play a crucial role in it. However, the role of NK cells in the pathogenesis of sepsis is still controversial and there remains a gap in understanding the exactly immune responses of NK cells to sepsis and even infections secondary to sepsis. In this study, we used sepsis mouse models to investigate the alterations of NK cells, and then we subjected the septic mice to a secondary influenza A virus (H1N1) infection to characterize the anti-infection immune responses of NK cells. Here, we demonstrated that NK cells presented an activated phenotype in early phase of sepsis as illustrated by increased activated CD69 and NKG2D and reduced inhibitory KLRG1 expression on NK cells. Moreover, we observed that NK cells were excessive overall activated in the sepsis mouse model subjected to secondary infections as illustrated by cell surface receptor expression profiles, increased IFN-γ and CD107a expression after stimulation, aggravated lung inflammation and pathological injury, and increased systemic inflammation cytokines, which might be an important reason for higher mortality in PR8-infected sepsis mice. In summary, NK cells exhibit excessive activated phenotype induced by sepsis, contributing to unrestrained systemic inflammation, pathogenesis of tissue damage, physiological dysfunction, and increased mortality.
Rezension zu: Hedwig Schmalzgruber (Hrsg.), Speaking Animals in Ancient Literature.
Authors: Schneider Horst
Published: May 2022

-
Logarithmic, noise-induced dynamics in the Anderson insulator
Authors: L. M. Lezama Talía , Bar Lev Yevgeny
Published: May 2022

We study the dynamical behavior of the one-dimensional Anderson insulator
in the presence of a local noise. We show that the noise induces logarithmically
slow energy and entanglement growth, until the system reaches an infinite-temperature
state, where both quantities saturate to extensive values. The saturation
value of the entanglement entropy approaches the average entanglement
entropy over all possible product states. At infinite temperature,
we find that a density excitation spreads logarithmically with time,
without any signs of asymptotic diffusive behavior. In addition, we
provide a theoretical picture which qualitatively reproduces the phenomenology
of particle transport.
Is Haplothrips clarisetis Priesner (Thysanoptera: Tubulifera) an Economic Threat to Table Grapes in the Lower Orange River Production Region of South Africa?
Authors: Allsopp Elleunorah , Stiller Michael
Published: May 2022

Table grape producers and consultants in the Lower Orange River region, Northern Cape province,have been reporting conspicuous, fairly large, black thrips on new growth and inflorescences early inthe growing season in recent years. These thrips were identified as Haplothrips clarisetis Priesner andH. nigricornis Bagnall, both indigenous species widely distributed in South Africa and Africa. The aimof this investigation was to determine if H. clarisetis causes any damage to table grapes and if it posesan economic threat to the industry in the Northern Cape province. Inspections were conducted overtwo seasons during flowering and fruit set, prior to and after harvest in four vineyards near Augrabies(28.7630 S, 20.5668 E) and four in the Blouputs Valley (28.4631 S, 20.0789 E) where Haplothrips hadpreviously been reported. Developing inflorescences, bunches, leaves and shoot tips were inspected for thepresence of Haplothrips and for any signs of feeding damage. Very few thrips were found and no signs offeeding were observed. Adult H. clarisetis were collected from flowering grape bunches and from flowersof Osteospermum microcarpum (Asteraceae) and Mesembryanthemum crystallinum (Aizoaceae) growingwild adjacent to the vineyards and confined on grapevine flowering bunches, leaves and a single shoot tip.Daily inspections showed no signs of feeding damage on the shoot tip, leaves or inflorescences and thripsdid not survive for more than three days on average. We therefore conclude that H. clarisetis does not posean economic threat to table grapes in the Lower Orange River region.
conduta, a fala e o juízo: pressupostos éticos a partir de Merleau-Ponty
Authors: Hadlich Josiana
Published: May 2022

O artigo presente aborda a análise da possiblidade de uma fundamentação ética a partir da experiência do outro compreendido como uma presença carnal e como realização concreta de gestos. A familiaridade estampada entre o eu e o outro na forma de tratar as coisas mundanas e a dessemelhança em muitas condutas intencionais, leva o eu a abrir um leque de reflexões sobre si mesmo, tornando possível um logos ético. Os gestos e as palavras constituem os elementos principais da experiência intersubjetiva fundando o estatuto de uma reflexão ética. Com isso, significados serão emergidos a partir da fala, mostrando que a linguagem alarga a abertura do mundo comum entre os sujeitos falantes. Na abertura intersubjetiva instaurada pela linguagem, valorações e expressões são contextualizadas em vivências culturais que, em muitos aspectos, são inconciliáveis. Em razão disso, a reflexão da consciência é ativada na medida em que esta já se encontra entranhada no mundo por meio de significações.
A filosofia do corpo de Maine de Biran: Do fato primitivo ao esforço
Authors: De Oliveira André Renato
Published: May 2022

Este artigo aborda a questão do corpo na filosofia de Maine de Biran. Trata-se em demonstrar como esse filósofo traz à tona um novo estatuto do corpo que se originaria a partir da identificação do fato primitivo ao esforço, isto é, Maine de Biran demonstra que o eu não pode existir por si mesmo sem ter o sentimento imediato interno da coexistência do corpo. Disso advém sua formulação do corpo subjetivo. Essa nova abordagem trará consigo a construção de uma ontologia subjetiva, com a qual Henry, M. (1965) sustenta ser capaz de fundamentar uma fenomenologia do corpo. Demonstrar a originalidade dessa concepção do corpo biraniana e avaliar a validade de sua acepção fenomenológica é com o que nos ocuparemos neste trabalho.
Amar a Pátria mais do que a própria Alma: Corrupção, Conflito e Liberdade em Maquiavel
Authors: De Assis Jean Felipe
Published: May 2022

A corrupção, inexorável nos regimes políticos e nos costumes sociais, pode ser a condição para a restauração da cidade ou a causa de sua ruína, adquirindo contornos ambíguos e ambivalentes em muitas passagens do corpus Maquiaveliano. Ela pode ser utilizada para conquistar o domínio, embora cause grandes dificuldades para a sua manutenção, mas também incentivada para o enfraquecimento das instituições com a finalidade de aumentar os benefícios das facções em disputas em uma cidade. Desse modo, o crescimento da corrupção, um mal social, destrói a civilidade e perverte os costumes dos cidadãos, subjugando a liberdade. O amor à pátria deve incentivar contínuas batalhas à corrupção, abolindo as facções mediante conflitos que visem à satisfação de todos os cidadãos para a manutenção da liberdade. Analisar-se-ão passagens significativas no corpus de Maquiavel sobre a corrupção (P. VII; D. I.10;16;17;18;29; IF. III.5); discutir-se-ão algumas consequências da corrupção e algumas formas de conter seus efeitos ao fundar novas ordens ou refundar a partir dos princípios norteadores de um regime existente; e, por fim, apresentar-se-á a relevância do pensamento do secretário florentino sobre a corrupção nos pensamentos republicanos modernos e contemporâneos.
O que é seu é meu e o que é meu... é meu: a biopolítica e a uberização da vida
Authors: Sampaio de Freitas Felipe
Published: May 2022

A biopolítica, para Michel Foucault, poderia ser entendida como aquilo que faz viver e deixa morrer. Ao largo de sua trajetória intelectual, especificamente, na segunda metade da década de 1970, o filósofo francês desenvolveu essa questão em alguns de seus Cursos dados ao Collège de France. No curso de 1979, ele indica uma faceta biopolítica atuante na dimensão da constituição de subjetividade, tendo como background a chamada governamentalidade neoliberal, isto é, o homo oeconomicus. Este artigo tem como principal objetivo a análise do neoliberalismo hoje, no tocante à temática do avanço das novas tecnologias e da internet sobre o trabalho, levando em conta o quesito da precarização, ou, uberização. Entretanto, buscaremos problematizar os vieses biopolíticos concernentes à esta questão. Nossa exposição obedece a três etapas: 1- A justificativa teórico-metodológica das razões para se buscar entender a temática por meio da biopolítica; 2- A apresentação da temática da uberização e, consequentemente, a elucidação da chamada economia de compartilhamento; 3- A exposição da constituição de uma subjetividade neoliberal, uberizada, no trabalho e na vida. Como conclusão, entende-se que vivemos em um novo regime do normal, que implica em resistências outras, para o arrefecimento de tais modos de subjetivação.
Debord e o hegelo-marxismo francês. Resenha de La librairie de Guy Debord. Marx Hegel.
Authors: Lyra de Carvalho Frederico
Published: May 2022

Resenha do livro Debord, Guy. La librairie de Guy Debord. Marx Hegel. Paris : L’Echapée, 2021.
Evaluation of the Nimbamrithadhi Panchathiktha Kashayam against SARS
CoV-2 based on Network Pharmacology and Molecular Docking analysis
Authors: Presanna Aneesh T. , Nath Lekshmi R. , Murali Maneesha , Nair Bhagyalakshmi , Radhakrishnan Vishnu V.
Published: May 2022

Background:

Nimbamrithadhi Panchathiktha Kashayam (NPK) is an Ayurvedic formulation
of potent plant ingredients with immune-modulating effects and anti-viral activities.

Objectives:

The present study is intended to identify the key target involved in immune and inflammatory
response against SARS-COV-2 via network pharmacology and also investigates the potent
phytoconstituent within NPK in combating or modulating target response via molecular docking.

Methods:

Active phytoconstituents of NPK were filtered based on overall bioavailability and druglikeness
by Lipinski’s and ADMETOX prediction.

Results:

Results indicate that IRF 7 can be selected as an efficient target in regulating immunomodulatory
and anti-viral activity via network pharmacology. Molecular docking studies show that
apigenin (22.22 Kcal /mol), thiamine (24.89 Kcal /mol) and esculetin (25.21 Kcal /mol) within
Nimbamrithadhi Panchathiktha Kashayam(NPK) possess better binding affinity in comparison
with standard drug gemcitabine (14.56 Kcal /mol). Even though docking score is more for Esculetin
and Thiamine, Apigenin within Solanum Virgianum (Yellow nightshade) and Azadirachta
Indica (Neem) is considered as the active phytoconstituent in modulating immune responses and
anti-viral activities based on the number and nature of amino acid interaction.

Conclusion:

To the best of our knowledge, no scientific validation has been done on NPK against
COVID-19. The study indicates that NPK can be a better alternative prophylaxis strategy against
SARS-COV-2 infection if further validated via suitable preclinical studies.
A Novel Risk Model of SUMOylation-related Genes Associated with Prognosis
in Endometrial Cancer
Authors: Cheng Xi , Lei Yajie , Xu Qing , Chen Yixin , Li Haoran
Published: May 2022

Background:

Endometrial cancer is ranked fourth in women's cancers worldwide.
SUMOylation is a process of post-translational modification and some evidence indicate that
SUMOylation may influence the occurrence and development of cancer. Until now, the prognostic
value of SUMOylation-related genes in endometrial cancer remains unclear. Therefore, we aimed
at exploring the prognostic value of SUMOylation-related genes in endometrial cancer in this
study.

Methods:

The transcriptome of endometrial cancer from TCGA database was downloaded and
then differentially expressed SUMOylation-related genes were extracted. The risk model was constructed
with the use of the least absolute shrinkage and selection operator Cox regression. Samples
were divided into low-risk and high-risk group based on the risk score. Survival analysis and
Cox analysis were performed between groups. A validation cohort from Fudan University Shanghai
Cancer Center were obtained to verify the model. Gene ontology and Kyoto Encylopedia of
Genes and Genomes analyses were conducted based on differentially expressed genes between
groups.

Results:

Samples in low-risk group possess better outcome than in high-risk group. (P<0.001) The
results of univariate (P<0.001) and multivariate (P=0.018) analysis showed that the risk score was
independently correlated to worse outcome for patients with endometrial cancer. In Fudan University
Shanghai Cancer Center validation cohort, the low-risk group possessed better survival outcome
than the high-risk group (P=0.0393). Functional analysis demonstrated that most of the immune
cell infiltration levels and immune pathways activity in low-risk group were higher than in
high-risk group.

Conclusions:

In short, the SUMOylation-related signature had good predictability in endometrial
cancer and SUMOylation-related genes play important roles in tumour immunity. Also, our study
might have some merits in elucidating potential mechanism of SUMOylation in endometrial cancer.
Deciphering the Role of S-adenosyl Homocysteine Nucleosidase in Quorum
Sensing Mediated Biofilm Formation
Authors: Kaushik Sanket , Yadav Jyoti , Das Satyajeet , Singh Suraj , Jyoti Anupam , Srivastava Vijay Kumar , Sharma Vinay , Kumar Sanjit , Kumar Sujeet
Published: May 2022

S-adenosylhomocysteine nucleosidase (MTAN) is a protein that plays a crucial role in several
pathways of bacteria that are essential for its survival and pathogenesis. In addition to the role of
MTAN in methyl-transfer reactions, methionine biosynthesis, and polyamine synthesis, MTAN is also
involved in bacterial quorum sensing (QS). In QS, chemical signaling autoinducer (AI) secreted by
bacteria assists cell to cell communication and is regulated in a cell density-dependent manner. They
play a significant role in the formation of bacterial biofilm. MTAN plays a major role in the synthesis
of these autoinducers. Signaling molecules secreted by bacteria, i.e., AI-1 are recognized as acylated
homoserine lactones (AHL) that function as signaling molecules within bacteria. QS enables bacteria
to establish physical interactions leading to biofilm formation. The formation of biofilm is a primary
reason for the development of multidrug-resistant properties in pathogenic bacteria like Enterococcus
faecalis (E. faecalis). In this regard, inhibition of E. faecalis MTAN (EfMTAN) will block the QS and
alter the bacterial biofilm formation. In addition to this, it will also block methionine biosynthesis and
many other critical metabolic processes. It should also be noted that inhibition of EfMTAN will not
have any effect on human beings as this enzyme is not present in humans. This review provides a comprehensive
overview of the structural-functional relationship of MTAN. We have also highlighted the
current status, enigmas that warrant further studies, and the prospects for identifying potential inhibitors
of EfMTAN for the treatment of E. faecalis infections. In addition to this, we have also reported
structural studies of EfMTAN using homology modeling and highlighted the putative binding sites of
the protein.
Enhanced Brain Delivery via Intranasal Administration of Carbamazepine
Loaded Solid Lipid Nanoparticles: Optimization, Pharmacokinetic Analysis,
In-vitro, and In-vivo Drug Release Study
Authors: Arya Rajeshwar Kamal Kant , Vijay Juyal , Bisht Dheeraj , Rashid Mohammad , Alfawaz Altamimi Abdulmalik Saleh , Afzal Obaid , Sethiya Neeraj Kumar
Published: May 2022

Background:

Carbamazepine (Cbz) is the first-line drug for epileptic seizures but exhibits
fluctuation at the plasma level and side effects after oral administration.To overcome these problems,
Cbz should be targeted directly into the brain. Therefore, the current experimental design was aimed to
formulate and optimize the Cbz containing solid lipid nanoparticles (SLNs) for brain delivery via intranasal
administration to get rid of oral complications associated with Cbz.

Methods:

A full factorial design was performed to evaluate the effect of variables (X1 lipid concentration,
X2 surfactant concentration, and X3 sonication time) on the response variables (size of nanoparticles,
entrapment efficiency, and drug release). A two-level, three-factor design was employed herewith,
and eight formulations were developed. Further, the formation of Cbz containing SLNs was characterized
by compatibility, particle size, entrapment efficiency, and drug release with the support of Fourier
Transform Infra-Red (FTIR), Zeta sizer, Transmission Electron Microscopy (TEM), Ultra-violet (U.V.),
and High-Performance Liquid Chromatography (HPLC).

Results:

All eight formulations were characterized through particle size, entrapment efficiency, and invitro
drug release performance. Out of eight characterized formulations, SN1 showed the most promising
results, including particle size of 210 ± 2.14 nm, entrapment efficiency of 42.1 ± 1.09%, and drug
release of 61.3 ± 2.02% and considered an optimized batch. Additionally, the optimized batch SN1was
further evaluated for an in-vivo study on male Wistar Rats.

Conclusion:

The study revealed that a high amount of drug was reached into the brain through intranasal
administration compared to the intravenous route. Therefore, it can minimize the unwanted side
effects of the Cbz associated with oral administration. The formulation SN1 possesses an excellent drug
targeting efficiency of 3.014. Finally, the current experimental work concluded that there is a direct
pathway from the intranasal route to the brain. This delivery system can be beneficial for directly delivering
CNS-active drugs into the brain.