bluuebunny/crossref_metadata_2025 huggingface dataset:
Felis catus gammaherpesvirus 1 (FcaGHV1) and coinfections with feline viral pathogens in domestic cats in Brazil
Authors: Kurissio Jacqueline Kazue , Rodrigues Marianna Vaz , Taniwaki Sueli Akemi , Zanutto Marcelo de Souza , Filoni Claudia , Galdino Maicon Vinícius , Araújo Júnior João Pessoa
Published: March 2018

ABSTRACT: Felis catus gammaherpesvirus 1 (FcaGHV1) may causes an asymptomatic infection that result in an efficient transmission and subsequently dissemination of the virus in feline population. This study used molecular detection by qPCR (quantitative PCR) based on DNA polymerase gene fragment amplification to evaluate the occurrence of FcaGHV1 and its correlation with other feline viral pathogens, such as Carnivore protoparvovirus 1 (CPPV-1), Felid alphaherpesvirus 1 (FeHV-1), and feline retroviruses such as feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). Of the 182 blood samples evaluated 23.6% (43/182) were positives for FcaGHV1. Approximately 37.9% (33/87) of the samples that tested positive for retrovirus were also were positive for FcaGHV1 infection (P<0.0001). Among FIV-infected samples, 49% (24/49) were positive for FcaGHV1 (P<0.0001). FcaGHV1 infection was not associated with FeLV (P>0.66) or CPPV-1 (P>0.46) coinfection. All samples were negative for FeHV-1. Male felines were significantly associated to FcaGHV1 (P<0.0001) and their risk of infection with FcaGHV1 was about of 7.74 times greater compared to females. Kittens (≤ 1year) were the least affected by FcaGHV1 infection, being verified a rate of 7.7% (4/52). Therefore, male cats over one year old and infected with FIV were considerably more likely to be infected with FcaGHV1. To our knowledge, this is the first study to report the occurrence and molecular detection of FcaGHV1 infection in domestic cats in Brazil and in South America.
Neck circumference in adolescents and cardiometabolic risk: A sistematic review
Authors: Morais Aisha Aguiar , Morais Urjel Aguiar Bouissou , Soares Maria Marta Sarquis , Romano Márcia Christina Caetano , Lamounier Joel Alves
Published: March 2018

Summary Objective: To critically analyze articles on the relation between neck circumference (NC) in adolescents and: body mass index, fat distribution, metabolic syndrome and its individual components, and cardiovascular risk. Method: Systematic review undertaken by two independent researchers using the Pubmed/Medline, Lilacs/Medline, Scielo and Cochrane databases in English, Spanish and Portuguese in the period comprising the past 5 years. Results: Eighteen (18) articles were selected. The articles show an association between NC in adolescents and body fat (BMI), central fat distribution (WC), metabolic syndrome and several of its individual components, and cardiovascular risk. Some values are proposed for NC cutoff points as a diagnostic tool for nutritional status, high blood pressure and pre-hypertension, cardiovascular risk, insulin resistance and metabolic syndrome. We identified a percentile curve constructed for Brazilian adolescents. Conclusion: There is a shortage of studies with representative samples, variety at the NC measurement sites, and the age of the participants, which makes it difficult to establish definitive landmarks.
Temperature affects the hypoxia tolerance of neotropical Cichlid Geophagus brasiliensis
Authors: Pereira Jéssica A. , Veronez Alexandra C.S. , Coppo Gabriel C. , Duca Charles , Chippari-Gomes Adriana R. , Gomes Levy C.
Published: March 2018

ABSTRACT Oxygen and temperature are the most limiting factors in aquatic environments. Several species are exposed to variations of these factors in water because of physical, chemical and biological processes. The objective of this study was to evaluate the metabolic profile and the tolerance to the hypoxia of Geophagus brasiliensis exposed to changes in temperature and oxygen availability. The fish were exposed to 20 and 90% of oxygen saturation combined with different temperatures (20°, 24° and 28° C) for 8 h. Hepatic and muscular glycogen, as well as the activities of lactate dehydrogenase (LDH), malate dehydrogenase (MDH), citrate synthase (CS) and their ratios were evaluated. Both glycogen and MDH activity showed a significant difference in the liver. While CS showed increased activity only in the heart. The increase in LDH activity in the white muscle shows the importance of the anaerobic pathway as energy source in this tissue. The MDH / LDH ratio increased in all tissues, while CS / LDH increased in the liver and decreased in the heart. Based on the results of the present study it may be concluded that this species used the anaerobic metabolism as the main strategy for hypoxia tolerance.
EVOLUTION OF MORTALITY FOR COLORECTAL CANCER IN BRAZIL AND REGIONS, BY SEX, 1996-2015
Authors: DUTRA Viviane Gomes Parreira , PARREIRA Virgilio Augusto Gomes , GUIMARÃES Raphael Mendonça
Published: March 2018

ABSTRACT BACKGROUND: Colorectal cancer is among the three most frequent neoplasms in Brazil, being a public health problem. OBJECTIVE: To describe distribution pattern of colorectal cancer mortality in Brazil and regions, according to sex, between 1996 and 2015. METHODS: Values of standardized and stratified mortality rates by sex between 1996 and 2015 were used, through polynomial regression models and joinpoint analysis. RESULTS: It was observed that, for linear trends in mortality rates, for both sexes, there is a statistically significant trend increasing in both models, with rates and trends, and higher for men than for women, respectively, 7.3% per year (R2=0.95, P<0.001) and 6.5% per year (R2=0.87, P<0.001). It is observed a difference in magnitude and behavior of trend between the regions. CONCLUSION: It is understood that it is important to know the trend of rates in order to define priority populations for early interventions that increase survival and reduce mortality.
Costs and benefits of highway resurfacing: a case study of Interstate 465 in Indiana, USA
Authors: Alqadhi Saeed , Ghahari Seyed Ali , Chen Sikai , Volovski Matthew , Woldemariam Wubeshet
Published: March 2018

Highway restoration projects reduce subsequent agency maintenance costs while providing user and community benefits through travel time savings, safety enhancement and reduced emissions. However, in implementing the project, significant costs are borne by the agency (paying the contractor), the user (workzone delays) and the community (emissions associated with the production process). It is useful to quantify these impacts and to assess the benefit–cost trade-offs that exist within and across the various stakeholder categories. This paper presents a case study that carries out evaluation of a highway pavement resurfacing project in terms of the various costs and benefits that are incurred by three key stakeholders: the agency, user and community. Recognising that most costs and benefits are strongly related to the pavement condition, the paper first determines the impacts of the resurfacing project on the pavement condition. This paper not only provides an assessment of the overall economic efficiency of a resurfacing project, but also sheds light on the trade-offs that highway decision makers implicitly encounter in terms of the stakeholder costs and benefits.
Uluslararası Hukuk Çerçevesinden Arktik Güvenliği Politikalarının Analizi: Rusya ve ABD Örneği
Authors: Güçlü Akpınar Burcu
Published: March 2018

Son yıllarda artan

küresel ısınma ile beraber kuzey kutbunu kaplayan buz tabakası daha fazla

erimeye başlamıştır. Eriyen tabaka deniz alanını daha kullanılabilir bir duruma

getirmiş ve deniz tabanında yer alan hidrokarbonlara erişim daha kolay hâle

gelmiştir. Bu iklimsel değişime bağlı olarak ülkelerin bu alan ile ilgili

politikaları da ciddi anlamda değişime uğramıştır. Öyle ki, dünyanın belki de

en zorlu yaşam koşullarına ev sahipliği yapan Arktik bölgesi ekonomik ve

siyasal kazanımların odak noktası haline gelmiştir. Bölgenin uluslararası

statüsü ve egemenlik alanları konusunda tartışmalar baş göstermiştir. Böylece

Arktik O’na komşu olan ülkeler arasında çıkarların çatıştığı bir alana

dönüşmüştür. Bu durum Rusya ve ABD’nin rekabet koşullarının değişmesine de

neden olmuştur. Ayrıca Arktik, küresel ölçekte yaratmış olduğu etkileri ile

birlikte düşünüldükçe, giderek sorunlu bir bölgeye dönüşmektedir. Bu sorunların

çözümü için ise, uluslararası hukukun esas alınması ihtiyacı doğmaktadır. Bu

çalışma, Rusya ve ABD’nin Uluslararası Hukuk çerçevesinden Arktik Bölgesi’ne yönelik

güvenlik politikalarını analiz ederek, bu politikaların iki devlet üzerinde ne

gibi siyasi, ekonomik ve sosyo-kültürel etkiler ortaya çıkardığını

tartışmaktadır.
Forecasting of Ra(226), Th(232) and U(238) Concentrations using Artificial Neural Networks (ANNs)
Authors: Bilici Sevim , Kamışlıoğlu Miraç , Bilici Ahmet , Külahcı Fatih
Published: March 2018

Identification and modeling of radioactive
concentrations in a region is very important for the region in terms of
radiological hazards. Artificial Neural Network (ANN) can successfully model
large systems. The validity of the
model was tested by entering the data of the proposed ANN model that had never
been entered into the system. In this research, average activity
concentrations of 226Ra, 232Th
and 238U in the water samples collected from the lake are 1.439 Bql-1, 4.508 Bql-1 and
14.682   Bql-1, respectively. The
characteristics of the study area are also determined with the spatial maps and
ANNs are used to prediction and modeling of the radionuclides. The mean square
errors for the obtained results are less than 1.5%. The correlation coefficient close to +1 indicates
the validity of the model for this study.
Índios
Authors: Esbell Jaider
Published: March 2018

Este ensaio é, basicamente, resultado de um projeto de pesquisa realizado durante os quatro anos que trabalhei como professora na Universidade Federal de Rondônia. O projeto, intitulado de “Livros da Floresta: do registro etnográfico à criação literária” (Edital Universal CNPq/2011), permitiu-me orientar oito estudantes do Curso de Letras como bolsistas do Programa de Iniciação Científica daquela instituição, com planos de trabalhos voltados para as literaturas de autoria indígena produzidas pelos povos Maxakali, Suruí Paiter, Kaxinawá, Yanomami, Dessana, Pataxó e Cinta Larga. Neste ensaio, analisamos especificamente três livros escritos, respectivamente, pelos Kaxinawá, pelos Dessana e pelos Maxakali, para, a partir desta experiência de leitura, problematizarmos as relações entre mito e literatura e os alcances de nossos modos de ler a autoria indígena na contemporaneidade.
Mitologia moderna e iluminação profana
Authors: Andrade Lucas Toledo de
Published: March 2018

Esse artigo pretende investigar as relações entre mito e literatura trazidas pelo movimento surrealista, bem como o conceito de iluminação profana, oriundo dos estudos de Walter Benjamin a respeito dessa vanguarda. Para isso pretende-se abordar algumas criações elaboradas por importantes nomes do surrealismo, como é o caso de André Breton e Louis Aragon, por meio de uma leitura que tratará da possibilidade da criação de uma mitologia moderna e da relação disso com a ideia de iluminação profana, em obras como Nadja e Camponês de Paris, ambas de 1928, além disso, busca-se tratar do modo como o uso dos mitos, ressignificados na modernidade, por meio da aproximação entre arte e vida, permitiria um novo olhar do homem para o seu tempo e para o mundo que o rodeava, o que poderia, em última instância, revelar caminhos que levariam a transformação e ao reencantamento da realidade.
Prolegômenos ao mito ou sobre o fracasso da demitologização
Authors: Silva Bianka Teixeira de Andrade
Published: March 2018

Este trabalho problematiza e propõe uma noção de mito tendo como base as colocações de Odo Marquard e, sobretudo, de Roger Caillois. No intuito de atestar a indispensabilidade do conhecimento mítico para as culturas de todos os tempos e espaços, discorre-se, ademais, sobre o que é o método da demitologização e como representou um grande fracasso não só para aquele que o cunhou, o teólogo Rudolf Bultmann, como também para toda tendência de pensamento que buscou afastar o mito através da exacerbada instrumentalização da razão.
El Mito de Los Gemelos
Authors: Diegues Douglas
Published: March 2018

Douglas Diegues é poeta e organizador e tradutor da antologia de poesia guarani Kosmofonia mbya guarani, em co-autoria com o antropólogo e musicólogo Guillermo Sequera.
Kãns Kãns Karã - O canto do pica-pau
Authors: Castro de Souza Rafael
Published: March 2018

Neste ensaio, tratamos de um pequeno trecho da narrativa “Fumaça do tabaco”, mito do povo Huni Kuĩ presente no livro Shenipabu Miyui. Em um determinado momento dessa história, faz-se referência a um pica-pau cujo canto seria capaz de levar à morte aquele que o escuta. Propomos uma breve discussão sobre a (im)possibilidade de existência de um tal pássaro fora do âmbito literário, a partir de um excerto das Mitológicas de Lévi-Strauss. Apresentamos, em seguida, um aspecto do pensamento do filósofo Emanuele Coccia numa tentativa de equalização entre o canto dos pássaros e a música humana, para, enfim, retomarmos o discurso do antropólogo francês à luz do perspectivismo ameríndio de Eduardo Viveiros de Castro. Nosso intuito é demonstrar que, mais do que um pássaro literário, o pica-pau deste texto indígena é um ser existente real, que embora soe fantástico ao ouvido moderno, é perfeitamente concebível para o pensamento mítico do povo Huni Kuĩ.
Deformação da Literatura Brasileira
Authors: Ferreira Rafael Otávio Fares
Published: March 2018

Este ensaio-manifesto busca colocar algumas questões relativas aos textos que tem sido publicados, principalmente por povos indígenas, e não são entendidos como literatura pelas universidades, nem tampouco são lidos, apesar da lei 11.645 de março de 2008 que estabelece que é obrigatório o ensino de culturas indígenas e africanas no Brasil. O argumento para o texto é retirado da palestra "A literatura brasileira da perspectiva pós-colonial" feita por Silviano Santiago que afirma que a literatura brasileira já está formada e é preciso desconstruí-la, ampliando a inserção de outros textos que não os do sistema já consagrado.
Tirar o risco
Authors: Turrer Daisy
Published: March 2018

Registro visual de dois trabalhos da professora e artista Daisy Turrer.
The association between blood glucose level and cognitive dysfunction among acute traumatic brain injury in Manado, Indonesia
Authors: Sekeon Sekplin A. S. , Kembuan Mieke A. H. N.
Published: March 2018

Background: Traumatic brain injury (TBI) is a public health challenge. TBI contributes to chronic physical impairment and also disrupt mental and personality aspects. Cognitive dysfunction is influenced by multiple factors, including blood glucose level. The objective of the study was to analyze the association between blood glucose level and cognitive dysfunction among TBI patients.Methods: A hospital-based observational study was conducted with cross-sectional design for six months period. Population of research were all of TBI patients treated at the emergency unit. Eligible sample were obtained with total sampling technique. Dyslgycemia was defined as random blood glucose level outside the range of 80-200mg/dl; cognitive dysfunction was defined as MMSE score <26. Statistical analysis with SPSS version 17.0 was employed. Chi square test and odd ratio were executed, p value <0,05 were regarded as significant level.Results: Majority of the 124 patients was male (75.8%), in 21-30 age group (20.7%), mostly due to RTA, specifically from motorcycle-related accident. Most of the motorcyclist (56,5%) were not using helmet. Unconsciousness was in 65.8% sample. Seizure was found in 3.9% of total patients; almost half of patients had history of headache (40.8%). Vomit was found in 30.3% of patients. Vertigo or dizziness post-trauma was in 3.9% patients; almost one third of patients had history of alcohol consumption (30.3%). Majority (65.8%) were in GCS 13-15. Proportion of dysglycemia and cognitive dysfunction were 4.8% and 14.5% consecutively. Odd ratio analysis revealed that dysglycemic group have 3 times higher risk to develop cognitive dysfunction, but the association was statistically not significant.Conclusions: The association between random blood glucose level and cognitive dysfunction among acute traumatic brain injury was statistically not significant.
Visual evoked potentials in children with type 1 diabetes mellitus
Authors: Batta Meenal , Sharma Rajeev , Gupta Naveenta , Garg Sonia , Kaur Gurmeet , Dhir Shashi Kant , Kaur Amarpreet
Published: March 2018

Background: Insulin-dependent (type 1) diabetes mellitus is associated with different degrees of neuropathies affecting peripheral as well as central neural pathways. The subclinical neurological involvement in diabetic children can be assessed by changes appearing in the electrophysiological parameters like Visual Evoked Potentials (VEPs). The objective of the study was to assess the effect of type I diabetes melitus on the visual evoked potentials in children.Methods: This cross-sectional case-control study was done on 30 children with type 1 diabetes mellitus of minimum two years duration as cases and 30 age and gender matched euglycemic children with normal HbA1c taken as controls. Visual Evoked Potentials (VEPs) were done on both the groups of children and the latencies (ms) of waves -N75, P100, N145 and amplitude (μV) of wave P100 were recorded. The data was compiled in the pre-designed proforma and statistically analysed using student t-test.Results: The increase in the mean latencies of waveforms of VEPs N75, P100 and amplitude P100 were found to be highly significant statistically (p<0.001) in both the eyes among the children with type 1 diabetes mellitus. The mean latency of waveform N145 was found to be statistically insignificant in the two groups (p>0.05).Conclusions: The type 1 diabetes does affect the visual pathways in children. Visual Evoked Potentials are helpful in the detection of early changes in the conduction across the neural pathways in the sub-clinical diseases.
The relation of serum GGT level in patients with non valvular atrial fibrillation and normal sinus rhythm
Authors: Nawal C. L. , Chejara Radhey Shyam , Panwar Ankush , Agrawal M. K. , Singh Aradhana , Meena P. D.
Published: March 2018

Background: The primary objective of the study was to assess and compare the relation of serum GGT level in patients with non valvular atrial fibrillation and normal sinus rhythm. The fundamental mechanisms underlying AF remains poorly understood. Oxidative stress is hypothesized to induce and maintain nonvalvular atrial fibrillation particularly in elderly patients. GGT levels are increased in patients with chronic inflammation. Increased serum levels of GGT are found in chronic nonvalvular atrial fibrillation (AF) patients as compared with patients in sinus rhythm.Methods: We included 75 patients of nonvalvular atrial fibrillation and 75 patients of sinus rhythm after applying exclusion criteria. Serum level of gamma glutamyl transrerase (GGT) of both the groups was compared.Results: Presence of coronary artery disease, hypertension, gender, hyperlipidemia, diabetes mellitus and smoking status were comparable between the 2 groups (P > 0.05 for all). Serum gamma glutamyl transferase activity in 75 cases was 71.45±26.21 with maximum being 147 IU/L more than the normal range for age, whereas in controls it was 19.68±5.53 i.e. much within the normal range for age.Conclusions: At the end of the study we concluded that serum GGT levels were significantly higher in patients with chronic nonvalvular atrial fibrillation (AF) patients as compared with patients in sinus rhythm.
Latent coronary artery disease among smokers and smokeless tobacco users: a cross-sectional study
Authors: Mishra Dheerendra Kumar , Mishra Nimisha , Kumar Pradeep , Raghuvanshi Gyanendra
Published: March 2018

Background: Tobacco related mortality and morbidity and increase in developing country like India. WHO projected till 2020 India will accounts 15% of tobacco related mortality especially preventable causes of death e.g. cardiovascular disease. Active tobacco smoking is undoubtedly major risk factor for cardiovascular disease, but subjects use smokeless tobacco in dependence pattern is not extensively evaluated for cardiovascular risk factor. In India smokeless tobacco especially Khaini is major form of tobacco consumption. Scarcity of data on effects of smokeless tobacco in cardiovascular disease especially coronary artery disease major limiting factor for undermine the detailed evaluation of cardiovascular effects in smokeless tobacco dependence subjects. The aim of the study was to study the risk of coronary artery disease among smokeless tobacco dependence in comparison to tobacco dependence smokers.Methods: Cross-sectional assessments were done on 36 adults (>18 years), treatment-seeking patients with a ICD 10 diagnosis of Mental and behavioral disorders due to use of tobacco. Data was collected on socio-demographic characteristics, and after detailed clinical evaluation treadmill exercise test was done.Results: Mean age of tobacco dependence smokers 51.5±9.6 years vs 53.6±7.5 years. There were male predominant in study subjects and 38% subjects was treadmill test positive. Smokeless tobacco users had 35% positive treadmill test, and among Smokers 42% subjects was positive for treadmill test.Conclusions: Risk for latent coronary artery disease was similarly higher in smokers and smokeless tobacco dependence subjects.
Problemas Ontológicos da Filosofia da Tecnologia: natural e artificial na ética ambiental de Holmes Rolston III
Authors: Lenzi Letícia
Published: March 2018

A necessidade de se pensar a tecnologia é cada vez maior não apenas pela evidente relação das novas tecnologias com sérias questões de ordem ética que reclamam deliberação, mas principalmente porque a tecnologia influencia quase todos os âmbitos da nossa existência seja para permitir, melhorar ou facilitar a vida, seja para a produção sistemática de supérfluos que a ameaça. Neste artigo evidenciam-se questões ontológicas relativas ao conceito de natural e artificial no pensamento do filósofo ambientalista Holmes Rolston III, nome influente na construção de uma nova ética que promove o respeito pelo valor intrínseco da vida, considerando outras formas de vida como igualmente merecedoras de consideração moral.  As concepções ontológicas elucidadas por este autor nos permitem esclarecer algumas de suas propostas políticas que preconizam um efetivo gerenciamento da Terra, tendo em vista maneiras de conservar e criar espaços aonde o ser humano possa respeitar os ciclos naturais, ao mesmo tempo em que permite a criação de domínios de síntese, de interação equilibrada entre a esfera da cultura e a da natureza.
Alteraciones anatómicas e hiperplasia inducidas por Euphorbia mosaic virus aislamiento Yucatan Peninsula en el mesófilo
Authors: Gamboa-Tec Naivy , Kú-González Angela , Gutiérrez-Pacheco Luis Carlos , Castaño Enrique , López-Ochoa Luisa
Published: March 2018

Euphorbia mosaic virus aislamiento Yucatan Peninsula es un begomovirus bipartita con una amplia gama de hospedantes experimentales, que incluyen especies de importancia económica, como frijol, chile y tomate, entre otras. Este virus provocó síntomas severos en hojas de Nicotiana benthamiana, pérdida de identidad celular y tisular, deformaciones de la lámina foliar y de la nervadura central, cambios en la estructura del mesó- filo y proliferación celular, a diferencia de otros begomovirus bipartitas. Activó la expresión de los genes cycA1, cycA2 y cdkB2.2, implicados en la transición G2/M del ciclo celular mitótico y se localizó en el mesófilo de las hojas. EuMV-YP es el primer ejemplo de un begomovirus bipartita capaz de inducir la proliferación celular.
PRODUK BENANG SUTRA BERKUALITAS MELALUI TEKNIK SERIKULTUR DENGAN PAKAN YANG DIKEMBANGKAN SECARA IN VITRO
Authors: Faradilla Faradilla , Alias Sulfianto
Published: March 2018

Samarinda woven sarong is typical sarong of Samarinda. This sarong is still using silk spun silk raw material imported from Tiongkok. The development of aquaculture is needed to obtain local silk threads in order to help to reduce production costs in the samarinda silk industry. The high quality mulberry plants are needed to support silkworm cultivation (sericulture). The qualified mulberry plants are obtained by in vitro culture techniques. The objective of this study is to obtain mulberry leaf (Morus Sp) free from disease, uniform, and to obtain quality silk threads through sericulture techniques with feeds that were propagated in vitro. The research stages consist of sterilization, Murashige and Skoog (MS) media, sub culture, observation of data analysis fund. The design used is Completely Randomized Design with single factor, ie BAP concentration (control, 0.5 mg / l, 1 mg / l and 2 mg / l). Each treatment is repeated 8 times. The results showed that administration of ZPT 2 mg / l at age 4 MST gives the best response for all observed variables. The use of ZPT BAP with various concentrations produces the germination rate, shoot height, number of shoots and number of different leaves. All treatments are unsuccessful in inducing roots.Keywords: in vitro; Murbei; SericultureSarung tenun samarinda adalah sarung khas kota Samarinda. Sarung ini masih menggunakan bahan baku sutera jenis spun silk yang diimpor dari Tiongkok. Pengembangan serikultur diperlukan untuk mendapatkan benang sutera lokal. Sehingga membantu mengurangi biaya produksi dalam industri persuteraan samarinda. Tanaman murbei yang berkualitas diperlukan untuk menunjang budidaya ulat sutera (serikultur). Tanaman murbei yang berkualitas diperoleh dengan teknik kultur in vitro. Tujuan penelitian adalah memperoleh daun murbei (Morus Sp) yang bebas penyakit dan seragam serta memperoleh benang sutera berkualitas melalui teknik serikultur dengan pakan yan diperbanyak secara in vitro. Tahapan penelitian terdiri dari sterilisasi, pembuatan media Murashige dan Skoog (MS), sub kultur, Pengamatan dana analisis data. Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan faktor tunggal yaitu berbagai konsentrasi BAP (kontrol, 0,5 mg/l, 1 mg/l dan 2 mg/l) setiap perlakuan diulang 8 kali. Hasil penelitian menunjukkan bahwa pemberian ZPT 2 mg/l pada umur 4 MST memberikan respon terbaik untuk semua variabel yang diamati, Penggunaan ZPT BAP dengan berbagai konsentrasi menghasilkan waktu kecepatan bertunas, tinggi tunas dan jumlah tunas dan jumlah daun yang berbeda. Semua perlakuan tidak berhasil dalam menginduksi akarKata kunci : in vitro; murbei; serikultur
Fatty acid binding proteins (FABPs) – a new laboratory biomarker for kidney diseases
Authors: Dobrek Łukasz
Published: March 2018

Fatty acid binding proteins (FABPs) are a family of intracellular proteins involved in metabolism of lipids. By regulating the intracellular level of free fatty acids, those proteins indirectly influence intracellular signaling pathways. FABPs also play a role in regulation of cell growth and differentiation, and exert a significant antioxidant effect. Some reports suggest that FABPs are released by various organs (heart, liver, intestines, kidneys) in response to tissue damage. The article briefly summarizes the structure, classification and function of FABPs and discusses the applicability of liver- (L-FABP) and heart-type (H-FABP) FABPs in laboratory diagnosis of selected clinical entities, particularly kidney diseases.
Mesotherapy – a method of facial skin rejuvenation from an interdisciplinary perspective on improving facial aesthetics
Authors: Magdalena Bernacka, Maciej Lichaj Teresa Matthews-Brzozowska, Monika Łącka
Published: March 2018

Mesotherapy has been used in medicine since the 1950s and for aesthetic procedures since the 1970s. In the medical literature there are numerous reports about the positive effect of mesotherapy with regard to rejuvenating and improving the appearance of facial skin (reduction of fine wrinkles and discolouration, facial contour correction, improvement in skin tightness and elasticity). The variety of formulations used and the different techniques for administering them mean that the subjectively observed effects of mesotherapy cannot be objectively verified. To date, only a few studies have been published in the international literature where histopathological, ultrasound, and electron microscopy examinations were performed to confirm the efficacy of this method. Most studies, however, have been based on assessing subjective improvement. The aim of this paper was to review literature on the subject, namely 15 full-text reports on the effects of mesotherapy in the treatment of facial skin. The findings of the review show that the studies published to date are based primarily on subjective assessment methods, presenting the results of mesotherapy procedures through an analysis of "before and after" medical photographic documentation. It would seem necessary that further research should be conducted based on a unified protocol.
KAJIAN FERMENTASI KACANG TANAH DARI HASIL EKSTRAKSI MINYAK DENGAN CARA PENGEMPAAN
Authors: Susiloningsih Enny Karti Basuki , Susilowati Titi
Published: March 2018

N/A
DINAMIKA KELEMBAGAAN PERBENIHAN TANAMAN PANGAN DAN IMPLIKASINYA DALAM PENYEDIAAN BENIH BERMUTU DI KABUPATEN MERAUKE PAPUA
Authors: Malik Afrizal , Sudarsono Sudarsono
Published: March 2018

N/A
ASUPAN HARA TERHADAP KUALITAS DAN HASIL KELOPAK BUNGA DAN BIJI ROSELA (Hibiscus sabdarifa)
Authors: Rahardjo Suharto Ponco
Published: March 2018

N/A
INKORPORASI SULFUR DALAM PROTEIN ONGGOK MELALUI TEKNOLOGI FERMENTASI MENGGUNAKAN SACCHAROMYCES CEREVISIAE
Authors: Suprayogi Wara Pratitis Sabar
Published: March 2018

This research was conducted to determine the influence of incubation time and dose of sulphur in organik fermentation with Saccharomyces cerevisiae. This resech was in vitro at Laboratory Animal Nitrition. Departement Animal of Science, Agriculture Fakulty, Sebelas Maret University. This research was condukted for 3 month. The material were used cassava fermented with fungi Saccharomyces cerevisiae. And and the treatment of dose sulphur at 0 and 1500 mg/kg of substrate (water content 60%), time incubatin 2, 3 and 4 day. The result of experiment were analysed using completely randomozed design faktorial 2x3 and each treatment is repeated 3 time. The results of variance analysis showed that cassava fermented with Saccharomyces cerevisia with 3 day incubation time and addition of sulfur 1500 mg/kg can increase organic matter and protein content of biomassa fermentation significantly (p<0,05)but the level of crude fiber showed non significanly effects.
ANALISIS POTENSI DAN STRATEGI PENGEMBANGAN JAMU INSTAN DI KABUPATEN KARANGANYAR
Authors: Setyowati Nuning , Fajarningsih Rhina Uchyani , Adi Raden Kunto
Published: March 2018

This study aims to map the agro-rural instant herbal medicine in Karanganyar District, identifying rank (potential) of rural agro instant herbal medicine in the District of Karanganyar, formulating development strategies agroindusti rural development strategy and identify herbal instant maps of rural agro-industry business chain instant herbal medicine in the District of Karanganyar. The research method using descriptive analytical method, the technique of collecting data using surveys and focus group techniques. Analysis tools used include: Comparative Exponential Method, Borda method, SWOT and Value Chain. The results showed that the agro-instant herbal medicine spread in Jatipuro, Jenawi, Jumantono, Karanganyar, Kerjo, Mojogedang and Tawangmangu sub district. Instant herbal medicine al agroindustry is ranked second seed. Instant herbal medicine development strategy include: Increasing the ability of producers in diversifying the instant herbal products at affordable prices the market, increase market access for instant herbal product diversification, increase access to capital through access to financing institutions, development of product diversification while maintaining product quality, increase the ability of producers in access to quality raw materials at affordable prices, increase product quality with local raw materials, especially in terms of capital Strengthening of procurement of raw materials, and development of business partnerships in terms of procurement of raw materials. Business actors in the agroindustry are instant herbal-medicinal and medicinal farmers market vendors as suppliers of raw materials, manufacturers and marketers are as pengolahnya herbal merchants.
PEMBENTUKAN VARIETAS SIRSAK UNGGUL MELALUI PEMULIAAN POLIPLOIDI: INDUKSI POLIPLOIDI TANAMAN SIRSAK DENGAN KOLKISIN
Authors: Parjanto Parjanto
Published: March 2018

N/A
PENGARUH IMBANGAN PUPUK ORGANIK DAN ANORGANIK TERHADAP SERAPAN P DAN HASIL TANAMAN PADI SAWAH PADA DUA SISTEM BUDIDAYA DI LAHAN SAWAH SUKOHARJO
Authors: Hartati Sri , Sumani Sumani , Hendrata Henricus E. A.
Published: March 2018

This study aims to determine the effect of organic and inorganic fertilizers and cropping systems on P uptake and growth and yield of rice determine the most optimum. The research was conducted in paddy fields in the village of Subdistrict Wotgaleh Sukoharjo Sukoharjo in February 2013 to May 2013 . This research is using RCBD (Randomized Complete Block Design) with two factors . The first factor is the culture system consisting of two levels are conventional systems ( B1 ) and SRI systems ( System of Rice Intensification ) ( B2 ) . The second factor is the balance of organic and inorganic fertilizers ( P ) consisting of five levels are : ( P1 ) 100 % organic fertilizer ( Petroganik : 10 tons / ha ) , ( P2 ) 25 % organic fertilizer ( Petroganik : 2.5 tons / ha ) + 75 % inorganic fertilizer ( Phonska : 225 kg / ha ) + Urea : 150 kg / ha , ( P3 ) 50 % organic fertilizer ( Petroganik : 5 tons / ha ) + 50 % inorganic fertilizer ( Phonska : 150 kg / ha ) + Urea : 100 kg / ha , ( P4 ) 75 % organic fertilizer ( Petroganik : 7.5 tons / ha ) + 25 % inorganic fertilizer ( Phonska : 75 kg / ha ) + Urea : 50 kg / ha , ( P5 ) 100 % inorganic fertilizer ( Phonska : 300 kg / ha ) + Urea : 200 kg / ha . Parameters measured were available P , soil pH ( H2O ) , P network , stover dry weight , P uptake , total tiller number , and dry weight of harvested grain. The results showed that P uptake in conventional cropping systems is higher than the SRI cultivation system . P uptake in conventional cultivation of 0.135 g / clump whereas P uptake in SRI cultivation of 0.074 g / clump . Balance of organic and inorganic fertilizer with the highest P uptake was achieved in 100 % inorganic fertilizer , Phonska : 300 kg / ha + urea : 200 kg / ha which is 0.134 g / clump . The highest weight of dry grain harvest was achieved in the treatment of conventional cultivation system with 25 % organic fertilizer ( 2.5 t / ha Petroganik) and 7575 % inorganic fertilizer ( 225 kg / ha of fertilizer Phonska and 150 kg / ha urea ) that is equal to 12.98 tons / ha.
Delayed, Reversible Cervical Paralysis After Scoliosis Corrective Surgery in a Child with Osteogenesis Imperfecta
Authors: Goh Brian C. , Jain Amit , Sponseller Paul D.
Published: March 2018

Case:

A 12-year-old girl with osteogenesis imperfecta (OI) underwent posterior spinal arthrodesis (from T2 to the sacrum) for double major-curve scoliosis. She developed complete paralysis of all of the extremities 24 hours after surgery, without evidence of ischemia or infarction. The rods were removed, and the neurologic status improved; there was full restoration of strength within 1 week. She then underwent in situ fixation. At the 2-year follow-up, there had been no lapse in neurologic function.

Conclusion:

Reversible, distraction-induced neurologic deficits can occur outside of the instrumented spinal segment after corrective scoliosis surgery, particularly in patients with ligamentous laxity, as seen with OI.
Impresiones sobre Carne y Arena: práctica cinematográfica y realidad virtual
Authors:   Universidad Miguel Hernández, Martínez Cano Francisco Julián
Published: March 2018

Los productos audiovisuales han ido evolucionando de la mano de los avances tecnológicos durante el desarrollo histórico del ser humano. Desde finales del siglo XIX y hasta el momento actual, diversos artilugios y parafernalias técnicas han hecho posible el uso de imágenes en movimiento para contar historias, impulso inherente de la naturaleza humana. En el momento actual somos testigos de la aparición de las técnicas e instrumentos de realidad virtual para crear experiencias que alcanzan niveles de inmersión superiores a las técnicas de construcción del discurso audiovisual convencional. Esta tendencia se nutre de otros productos del medio como son los videojuegos, el arte contemporáneo, la fotografía, la publicidad y la narrativa, entre otros. Dentro de estos nuevos paradigmas encontramos Carne y Arena, del director Alejandro González Iñárritu, uno de los últimos intentos de romper las barreras y explorar nuevos caminos en cuanto a la creación de experiencias innovadoras para crear discursos narrativos. Este trabajo propone un estudio y análisis de esta pieza, con el objetivo de acercarnos a estos nuevos procesos de creación del discurso audiovisual, tratando de responder las cuestiones que plantean estos nuevos medios.
Implementasi Metode Enumerasi Implisit Untuk Penyusunan Menu Makanan Berdasarkan Kebutuhan Kalori
Authors: Saputra Adhie , Jek Siang Jong , Krisnawati Lucia Dwi
Published: March 2018

A simple eating disorder can create variety of disease. In this research, a diet menu created based on the needs of nutrition, using implicit enumeration method. The system will produce minimum price diet menu arrangement 3 times a day for a week, yet still fulfill customer’s nutrition need. Implicit Enumeration Method is used to generate the menu with minimum  price. More foods used in this calculation, the implicit enumeration utilization become more optimal. For 10 menus were used in the calculation, the node exploration will be 27.3% of the actual solution, whereas for 15 menus were used, the node exploration will be just 10.9%.
Ranking media for multi-pollutant removal efficiency in bioretention
Authors: Mei Ying , Gao Long , Zhou Hang , Wei Kun-Hao , Cui Na-Qi , Chang Chein-Chi
Published: March 2018

Bioretention is an effective best management practice for urban stormwater. This study aims to provide guidance for selecting the best bioretention medium in terms of pollutant removal capacity. Fuzzy set theory was applied with the improved analytic hierarchy process (IAHP) for weight determination, thus forming the fuzzy synthetic evaluation model, to assess the comprehensive efficiencies of certain sand media. This work is the first to use this method to study bioretention. Results demonstrated that the fuzzy synthetic evaluation model was a rational choice for the selection of bioretention media. The studied media were ranked by pollutant removal capacity as follows: Media III > Media V > Media I > Media VI > Media II > Media VII > Media IV. Media I had the best comprehensive removal efficiency and infiltration rate in bioretention. Moreover, the removal rates for Cd2+, Zn2+ and Pb2+ were excellent (>80%), those for Cu2+ and NH+4-N fluctuated from 58.1% to 92.7% and 64.7% to 95.9%, respectively, and those for NO−3-N and TP of the seven media did not show distinct differences.
Factors promoting resilience among Mexican immigrant women in the United States: Applying a positive deviance approach
Authors: Sajquim de Torres Maria , Lusk Mark
Published: March 2018

This research project used a positive deviance approach to identify Mexican immigrant women (MIW) who have experienced great stress and who have positive mental health indicators in order to determine the factors behind their resilience and coping skills. Signposts, strengths and resources contributing to positive mental health are identified and described. The resilience of participants in this study emerged as a very dynamic phenomenon. A series of internal assets helped these women find meaning, purpose and build resilience. Social networks, families, positive attitudes, and purposeful behaviors determine the strengths and well-being of this group. This may be the first exploration of the mental health assets of MIW. Although the purposive sample in the study limits the generalization of its results, the specificity of its population is a clear point of comparison and reference. The study has implications for the design of health promotion interventions with individuals of Mexican shared ancestry.
2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview
Authors: Singh Pramod , Singh Jitendra , Pant Geeta J. , Rawat Mohan S.M.
Published: March 2018

Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as
medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic
and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer,
antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides,
fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known
brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in
synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines
have also been investigated by several research groups. In this review, most of the synthesized and reported
nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation
and structure-reactivity are discussed.
Bioinformatics Based Understanding of Effect of Mutations in the Human β Tubulin Outside Drug Binding Sites and its Significance in Drug Resistance
Authors: Kumar C Selvaa , Dasgupta Debjani , Gadewal Nikhil
Published: March 2018

Background:

Human β tubulin displays resistance to drugs like Taxol and Vinblastine due to amino acids substitutions within and outside the drug binding site.

Objective:

This study focuses on the effect of amino acid substitutions outside the drug binding site on drug resistance. Amino acid substitution like R306C (mut2) is associated with Taxol resistance and D197N (mut1) and K350N (mut3) are associated with Vinblastine resistance. However, the mechanism of resistance has not been understood yet. This study has attempted to investigate the mechanism of resistance.

Methods:

SWISSMODEL server was used to model the wild and the mutant β subunits which were later considered for protein-protein and protein-ligand docking using HADDOCK and AutoDock 1.5.6 software respectively. Dimer mutants were generated using Swisspdbviewer. POCASA 1.1 server was used to calculate the overall effect of substitution on pocket volume and the effect of substitution on domain mobility was explored using GROMACS software.

Results:

From sequence perspective, amino acid replacement in all three positions viz. D197N (mut1), R306C (mut2) and K350N (mut3) were found to have a deleterious effect on the stability of the protein. This study was further confirmed through structural analysis. Change in hydrogen bonding pattern was observed within the site of substitution in modeled mut1 and mut3 which is known to be specifically involved in Vinblastine interaction. In mut2 associated with Taxol binding, the hydrogen bonding pattern remained unaltered. All three mutants showed better protein-protein (β-β) interactions compared to the wild-type. Pocket size analysis in β subunit revealed that Taxol binding site increased in size after substitution in mut2 compared to the wild-type. However, the size of the Vinblastine binding site in the dimer interface remained the same before and after the substitution in wild and the mutants. Wild-type (β monomer and αβ dimer) associated with Taxol and Vinblastine, respectively showed better drug interaction compared to their mutants.

Conclusion:

This study throws light on the mechanism of drug resistance due to amino acid substitutions outside the drug binding site. It was found that amino acid substitution outside the drug site enhanced protein-protein interaction between the β-β subunits.
Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease
Authors: García-Lara Lucía Gabriela , Morales-Martínez Adriana , Angeles-López Quetzalli Denisse , Pedraza-Espitia Hilda , Pérez-Neri Iván , Rodríguez-Balderas Cesar Augusto , Pérez-Severiano Francisca
Published: March 2018

Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the central nervous system that mainly affects the basal ganglia and has no cure. The mutation is located at an abnormal expansion of the CAG triplet in the Huntingtin gene. Humans show psychiatric, behavioural and motor disorders. Transgenic animal models are essential to the study of HD since the disease only affects humans. Therefore, the aim of this article was to describe the formation and maintenance of and to validate the progressive neurological phenotype of an R6/1 transgenic mouse colony. To achieve our objective, the colony founder was imported from Jackson Laboratories, and the mice were kept under controlled environmental conditions. The animals were bred at the vivarium of the Instituto Nacional de Neurología y Neurocirugía Man­uel Velasco Suárez. The R6/1 transgenic mice were successfully bred and showed genetic and phenotypic characteristics similar to the ones previously reported. Our colony is currently established and validated with the condi­tions of our vivarium and has produced more than four generations of R6/1 mice. The establishment of the R6/1 colony and its maintenance through generation is an advantage since it allows us to follow the authenticity of the transgenic mice regarding their phenotypic and motor behaviours. Fur­thermore, these animals can be compared with other transgenic mice that reproduce some of the main characteristics of the disease manifested in hu­mans, making these transgenic R6/1 mice a useful tool for the study of HD.
Acesso trans-hepático para hemodiálise: avanço ou retrocesso? / Transhepatic access for hemodialysis: progress or regression?
Authors: Moreira Ricardo Wagner da Costa
Published: March 2018

Em 2014, segundo a Sociedade Brasileira de Nefrologia em seu Inquérito Brasileiro de Diálise Crônica, 112.004 pacientes necessitavam de diálise crônica no país, número que representa um aumento de 20.000 pacientes em relação aos quatro anos anteriores. Desse total de pacientes, 91,4% fazem tratamento por hemodiálise e 8,6% por diálise peritoneal. Outro dado importante é que 29,0% dos pacientes estão em fila de espera por um transplante renal.1Para os pacientes que estão em hemodiálise, esta terapia necessita o acesso ao sistema vascular do paciente. O acesso vascular pode ser através do uso de cateteres venosos ou da criação de uma comunicação entre o sistema arterial e o venoso, nomeadamente a fístula arteriovenosa. No caso da fístula arteriovenosa, uma artéria e uma veia periférica de calibre adequado são escolhidas e uma comunicação entre as duas é criada cirurgicamente. No caso dos cateteres venosos, um cateter é inserido em uma veia de grosso calibre. Posteriormente, através de uma das vias, o sangue venoso é retirado pela máquina de hemodiálise e, após passar por filtração na máquina, é devolvido para a circulação venosa. As veias nas quais de rotina é possível inserir um cateter para hemodiálise são as veias jugulares internas, subclávias e femorais.2