bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimized Data-Independent Acquisition Approach for Proteomic Analysis at Single-Cell Level
Authors: Wang Yuefan , Lih Tung-Shing Mamie , Chen Lijun , Xu Yuanwei , Kuczler Morgan D. , Cao Liwei , Pienta Kenneth J. , Amend Sarah R. , Zhang Hui
Published: December 2021

Background: Single-cell proteomic analysis provides valuable insights into cellular heterogeneity allowing the characterization of the cellular microenvironment which is difficult to accomplish in bulk proteomic analysis. Currently, single-cell proteomic studies utilize data-dependent acquisition (DDA) mass spectrometry (MS) coupled with a TMT labelled carrier channel. Due to the extremely imbalanced MS signals among the carrier channel and other TMT reporter ions, the quantification is compromised. Thus, data-independent acquisition (DIA)-MS should be considered as an alternative approach towards single-cell proteomic study since it generates reproducible quantitative data. However, there are limited reports on the optimal workflow for DIA-MS-based single-cell analysis. Methods: We report an optimized DIA workflow for single-cell proteomics using Orbitrap Lumos Tribrid instrument. We utilized a breast cancer cell line (MDA-MB-231) and induced drug resistant polyaneuploid cancer cells (PACCs) to evaluate our established workflow. Results: We found that a short LC gradient was preferable for peptides extracted from single cell level with less than 2 ng sample amount. The total number of co-searching peptide precursors was also critical for protein and peptide identifications at nano- and sub-nano-gram levels. Post-translationally modified peptides could be identified from a nano-gram level of peptides. Using the optimized workflow, up to 1,500 protein groups were identified from a single PACC corresponding to 0.2 ng of peptides. Furthermore, about 200 peptides with phosphorylation, acetylation, and ubiquitination were identified from global DIA analysis of 100 cisplatin resistant PACCs (20 ng). Finally, we used this optimized DIA approach to compare the whole proteome of MDA-MB-231 parental cells and induced PACCs at a single-cell level. We found the single-cell level comparison could reflect real protein expression changes and identify the protein copy number. Conclusions: Our results demonstrate that the optimized DIA pipeline can serve as a reliable quantitative tool for single-cell as well as sub-nano-gram proteomic analysis.
Analysis of environmental hazards in the system «children's playground – urbanized area»
Authors: Stadnik Veronika
Published: December 2021

The article presents the results of the study of environmental pollution by methods of biological indication. The objects of research are children's playgrounds which are influenced by the negative anthropogenic factors. A child's body is more vulnerable to anthropogenic stresses. Car exhaust gases can have a negative impact on the respiratory, cardiovascular, nervous and other systems. Excessive noise pollution not only affects your hearing, but also other organs and systems. In addition, noise can increase stress hormone levels. The aim of the study is to identify the main adverse factors affecting playgrounds in large cities. Despite there are the sanitary standards for the placement of playgrounds in large cities, it was found that about 50 % of all playgrounds were located in violation of environmental safety standards. As part of the work, an inventory of children's playgrounds and sports grounds in the cities of Kyiv, Kharkiv and Dnipro was carried out. The author carried out experimental research on some playgrounds using biological indication methods. The method of lichen indication revealed that four out of ten playgrounds in Kharkiv have a high level of air pollution, and two out of ten in Kyiv and Dnipro. This is confirmed by the biotesting method. It was found that one of the methods of solving the problem of excessive anthropogenic load on the objects of study is planting greenery. It is experimentally established that green plantations are able to reduce the level of noise pollution by 4–6 dB and absorb pollutants. In addition to reducing the anthropogenic load, the greening of playgrounds has an impact on improving the microclimate of the urban environment, and developing the visual qualities of urbanised landscapes
Nanostructure reveals REE mineral crystallization mechanisms in granites from a heavy REE deposit, South China
Authors: Shi Aiguo , Xu Cheng , Chakhmouradian Anton R. , Smith Martin P. , Kynicky Jindrich , Fan Chaoxi , Wei Chunwan , Kuang Guangxi
Published: December 2021

Weathering crusts after granites are the most important source of heavy rare-earth elements (HREE) worldwide. Although HREE in these deposits is known to be inherited from parental rocks, the origin of HREE enrichment and the reasons why it is rare outside of China remains unclear. Here, we report the occurrence of variably organized nanoparticles of Ce-poor (<0.2 wt%), Nd-Y-rich bastnäsite-(La), and associated cerianite in parental granites from a HREE deposit, South China. The mineral contains high-HREE abundances (up to 13 wt% Y2O3). Synchrotron radiation-induced X-ray diffraction and high-resolution transmission electron microscopy analyses suggest that the mineral grew as disordered nanocrystals and (nearly) coaligned nanoparticle aggregations, thus supporting “nonclassical” crystallization mechanisms by particle attachment under hydrothermal conditions. The nanocrystal-line Ce-poor, Nd-Y-rich bastnäsite-(La) precipitated at rapidly decreasing temperature related to the influx of externally derived fluids, which caused CO2-H2O immiscibility and REE supersaturation. This interpretation is supported by petrographic data and microthermometric analysis of fluid inclusions in quartz. Unusually high fO2 resulted in Ce oxidation and decoupling from trivalent lanthanides, producing polycrystalline mineralization.
Note of the Editor-in-Chief and the Editor’s of the Special Issue
Authors: Maksymov Sergiy , Uvarova Olena
Published: December 2021

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Corporate Human Rights Obligations under Socio-economic Rights
Authors: Černic Jernej Letnar
Published: December 2021

In the chapter it is examined obligations of business in the field of socio-economic rightsThe author proceeds from the understanding of the importance of socio-economic rights to ensurethe livelihood of people and the creation of human opportunities, as well as their fundamental naturein terms of enjoying civil and political rights. The author is convinced that not only states, but alsocorporations, have certain obligations in the field of socio-economic rights. Because socioeconomicrights are linked to financial resources, corporations can make a significant contribution to securingthem in case of state fragility.The author analyzes international documents, compares national legal systems, as well as othersources (decisions of treaty bodies on human rights), and he concludes that corporate obligationsgain their legitimacy due to the horizontal application of national and international human rights law.It is noted that the UN Guiding Principles on Business and Human Rights, the OECD Guidelines forTransnational Enterprises, the UN Global Compact, the ILO Tripartite Declaration play a significantrole in promoting corporate human rights obligations in the field of socio-economic rights.The author also analyzes the significance of voluntary commitments of both individual corporationsand individual sectors that are generally the part of corporate policy and suggests their questionablelegal nature (lex imperfecta), as they do not provide sanctions for their violation.Analyzing the features of corporate obligations under socio-economic rights, the author takes asa basis the negative and positive dichotomy of human rights, as well as the approach embodied ininternational human rights law on three types of human rights obligations – to respect, protect, ensure.The author concludes that within each of the types of socio-economic rights obligations, corporationshave both preventive (negative and positive) and some corrective (negative and positive) obligations,especially where they control and/or or influence or in proximity of their operations.
Conceptualizing Corporate Accountability in International Law: Models for a Business and Human Rights Treaty
Authors: Bernaz Nadia
Published: December 2021

This article conceptualizes corporate accountability under international law andintroduces an analytical framework translating corporate accountability into seven core elements.Using this analytical framework, it then systematically assesses four models that could be used ina future business and human rights treaty: the United Nations Guiding Principles on Business andHuman Rights model, the Universal Declaration of Human Rights model, the progressive model, andthe transformative model. It aims to contribute to the BHR treaty negotiation process by clarifyingdifferent options and possible trade-offs between them, while taking into account political realities.Ultimately, the article argues in favour of the BHR treaty embracing a progressive model of corporateaccountability, which combines ambitious development of international law with realistic prospectsof state support.
Виклики та можливості розвитку прав людини і бізнес-сфери в Бразилії та Латинській Америці: теорія спільного конституційного проєкту для Латинської Америки (А Ius Constitutionale Commune)
Authors: Pamplona Danielle Anne
Published: December 2021

In her article, Brazilian professor Daniela Ann Pamplona describes the role of the JointConstitutional Project for Latin America (ICCAL) in strengthening the investment potential of LatinAmerican countries, strengthening the capacity of Latin American countries and businesses to respectand protect human rights. ICCAL is the latest theory developed by Armin von Bogdandi, MarielaMorales Antoniazzi and Flavia Piovesan at the Max Planck Institute for Comparative Public Law andInternational Law, which seeks to promote the transformation of social and political realities in LatinAmerica to create the necessary democratic conditions. and human rights. The current situation in theregion is characterized by a number of multifaceted challenges: high poverty rates, deep social gapsthat limit access to opportunities, especially for the most vulnerable; Ethnic groups and indigenouspeoples are not protected and respected in the implementation of macro-projects, such as mining,the lack of norms and practices on the obligation of companies to consult widely with indigenous andtribal peoples and to ensure their participation in any decision to intervene affects their territories.ICCAL’s approach to business and human rights is based on various Inter-American Court rulingsthat recognize the role of companies in adversely affecting human rights, but at the same time clearlyarticulate the human rights obligations of governments and businesses in terms of the HumanRights Guidelines. As the author explains, the potential role of ICCAL is that it can be a practicalguide for interpreting different national norms and helping to strengthen weaker states. It can alsostrengthen dialogue between countries in the region and with the Inter-American Human RightsSystem. Cohesion around the meaning and content of human rights will allow states and companiesto more effectively coordinate and coordinate actions to promote human rights.
The Category of “responsibility” in the Humanities and Law: A Multidisciplinary Approach
Authors: Sushchenko Volodymyr
Published: December 2021

The article is devoted to the theoretical foundations of the category of “responsibility” of philosophy and ethics, as well as its interpretation in psychology and jurisprudence. The author analyzes the category of “responsibility” in the context of etymology (origin) of this term in Ukrainian, Russian, English, French and German languages, while emphasizing their semantic similarity/identity. On the base of the analysis of scientific sources, an attempt was made to take a multidisciplinary approach to the interpretation of this category in jurisprudence in order to better and The article is devoted to the theoretical foundations of the category of “responsibility” of philosophy and ethics, as well as its interpretation in psychology and jurisprudence. The author analyzes the category of “responsibility” in the context of etymology (origin) of this term in Ukrainian, Russian, English, French and German languages, while emphasizing their semantic similarity/identity. On the base of the analysis of scientific sources, an attempt was made to take a multidisciplinary approach to the interpretation of this category in jurisprudence in order to better and
Chihuahua-Sacramento and Tabalaopa-Aldama aquifers of Chihuahua state, Mexico: linkage and importance of geostatistical and hydrogeochemical analysis
Authors: Núñez J. , Herrera E. , Navarro C. J.
Published: December 2021

The objective of this study is to gather sufficient information to make a diagnosis of drinking water sufficiency in the Chihuahua-Sacramento and Tabalaopa-Aldama aquifers. By applying advanced statistical techniques, the goal is to find the variables that control the regional and intermediate flow systems and establish the characteristics of a heterogeneous aquifer. The variables chosen from those established were as follows: total solids (TS), nitrates (NO3), fluoride (F), and total hardness, among others. In order to establish a conceptual model, the results from all the sampling were carried out by the National Water Commission (CONAGUA) in the aforementioned aquifers and were used to obtain an approximate flow differentiation. The results showed a good flow differentiation. In addition, a group of mixed water was detected among the intermediate and regional flows. The increase in the average regional flow values suggests a rise in the incidence of an upward flow of the regional flow as a result of uncontrolled extraction.
Independence of Regulatory Authorities in the Energy Market. Comment to the Judgement of EU Court of Justice in C-378/19 Prezident Slovenskej republiky
Authors: Szafrański Adam
Published: December 2021

In its judgement C-378/19, the Court of Justice of the European Union responded to the question for a preliminary ruling referred by the Slovak Constitutional Court. The ECJ found in this judgement that Directive 2009/72/EC must be interpreted as not precluding withdrawal of the competence of the President of a Member State to appoint and dismiss the chairperson of the national regulatory authority, and conferral of the same power to the Member State’s government. Similarly, allowing the participation of the Ministers of the Environment and of the Economy in certain price-setting procedures does not violate the decision-making independence of the national regulatory authority. In his commentary, the author cites the line of argument in the judgement and presents the political context in Slovakia that led to the preliminary question. The author then comments approvingly on the judgement, noting that the Court rightly refrained from assessing the political situation in Slovakia, instead opting to focus on the law. At the end of the commentary, the author makes remarks of a general nature relating to the independence of national regulatory authorities.
Interstate Application on Behalf of Organisations Lacking Non-governmental Status is Inadmissible. Comment on ECtHR Decision in Slovenia v. Croatia (Application No. 54155/16)
Authors: Cwicinskaja Natalia
Published: December 2021

The present commentary concerns the claims alleging a violation under Article 6(1) (right to a fair trial), Article 14 (Prohibition of Discrimination) and Article 13 (Right to an Effective Remedy) of the European Convention on Human Rights as well as Article 1 of Protocol No. 1 (Peaceful Enjoyment of Possessions) to the European Conventionon Human Rights by preventing Ljubljana Bank (a Slovenian bank) from enforcing and collecting the debts of its Croatian debtors in Croatia by the Croatian authorities. The case under discussion is an inter-state case and the applicant was the Republic of Slovenia. The decision is significant from the perspective of the development of case law in inter-state cases, which are still rare in the practice of the European Court of Human Rights. It has been confirmed that inter-state applications are additional measures for the protection of the rights of individuals which cannot be used to protect State interests.
In Vitro Fatigue and Fracture Load of Monolithic Ceramic Crowns Supported by Hybrid Abutment
Authors: Nawafleh Noor , Elshiyab Shareen , Öchsner Andreas , George Roy
Published: December 2021

Objective:

This study evaluated the performance of zirconia and lithium disilicate crowns supported by implants or cemented to epoxy resin dies.

Methods:

Eigthy zirconia and lithium disilicate crowns each were prepared and assigned in four groups according to the crown material and supporting structure combinations (implant-supported zirconia, die-supported zirconia, implant-supported lithium disilicate, and die-supported lithium disilicate). Ten crowns in each group acted as control while the rest (n=10) underwent thermocycling and fatigue with 100 N loading force for 1.5 million cycles. Specimens were then loaded to fracture in a universal testing machine. Data were analysed using one-way ANOVA and Tukey multiple comparison test with a 95% level of significance.

Results:

No implants or crown failure occurred during fatigue. The mean fracture load values (control, fatigued) in newton were as follows: (4054, 3344) for implant-supported zirconia, (3783, 3477) for die-supported zirconia, (2506, 2207) for implant-supported lithium disilicate, and (2159, 1806) for die-supported lithium disilicate. Comparing the control with the corresponding fatigued subgroup showed a significantly higher fracture load mean of the control group in all cases. Zirconia showed a significantly higher fracture load mean than lithium disilicate (P=0.001, P<0.001). However, comparing crowns made from the same material according to the supporting structure showed no significant difference (P=0.923, P=0.337).

Conclusion:

Zirconia and lithium disilicate posterior crowns have adequate fatigue and fracture resistance required for posterior crowns. However, when heavy fatigue forces are expected, zirconia material is preferable over lithium disilicate. Zirconia and lithium disilicate implant-supported crowns cemented to hybrid abutments should have satisfactory clinical performance.
Is Dental Panoramic Radiography Reliable to Assess Position of Bicortical Fixation Screws in Mandibular Fractures? Case Report
Authors: Albassal Ahmad , Al-Khanati Nuraldeen Maher , Harfouch Munir
Published: December 2021

Background:

Panoramic radiography is widely used as a diagnostic tool before oral surgeries and can be considered the foremost follow-up image after. It provides a broad observation of the maxillomandibular complex at a lower cost and radiation dose. But cone-beam computed tomography (CBCT) examination, after panoramic radiograph evaluation, can produce a change in the diagnostic thinking of maxillofacial surgeons leading to alterations in treatment plans.

Objective:

We aim to report a case with incidentally discovered radiographic findings where diagnostic changes were caused by switching from panoramic to CBCT imaging.

Conclusion:

Radiographic assessment of the position and angulation of screws by panoramic x-ray should be approached with extreme caution. The image of choice is CBCT if nerve injury is suspected.
Comparison of Surface Equivalent Dose in CBCT, Digital Panoramic and Intra-Oral X-Ray Generators Using InstadoseTM Device: An In-Vitro Study
Authors: Mathew Asok , Almahi Salam , Mohamed Razan , Abu Fanas Salem , Jaber Mohamed A. , Luke Alexander M. , Radeideh Ahmed , Shetty Shishir
Published: December 2021

Background:

Radiation protection in the dental examination is often overlooked because the doses delivered are negligible. However, the volume of dental radiological examinations will constitute almost 15% of all the radiological examinations carried out in the medical field.

Aim:

This study aims to evaluate and compare the surface equivalent dose on various target organs from various radiology devices on the RINN phantom, and the effect of numerous scanning protocols on said dose using dosimetry badge (Instadose).

Objectives:

The main objective is to study surface equivalent doses delivered in various critical organ regions in the facial region with the help of an Instadose device and to compare the doses delivered between 2D programs against 3D programs.

Materials and Methods:

RINN phantom was mounted on a dental chair for use against Planmeca ProMax 3D Classic and Planmeca intraoral ProX. Models. An Instadose badge was placed on various anatomical landmarks, and radiographic exposure protocols were applied to vary the parameters. The equivalent dose was calculated by connecting the dosimeter to a laptop and performing an instant reading output on the Instadose software.

Results:

The Thyroid showed a mean of 0.350, 0.0000, 0.0133, and 0.0000 in response to exposure by intraoral machine ProX, Panoramic, CBCT, and CBCT in ULD mode respectively. The dose absorbed by the left salivary glands was found to be significantly lower than the right salivary glands in panoramic exposures.

Conclusion:

It was revealed that a significant reduction in the dose when applying the Ultra-Low Dose protocol was noticed, and it reached up to 100% in the thyroid. It was also noted that there is no need for a thyroid collar in CBCT and Panoramic exposures. Maintaining the KVp at a constant and the exposure time as a variant caused a change in the dose equivalent received by the floor of the mouth and the right salivary gland.
Management of the Two Dental Developmental Anomalies in Two Maxillary Incisors for Improved Esthetic Appearance: A Case Report
Authors: AlDhelai Thiyezen A.
Published: December 2021

Introduction:

The presence of a developmental dental anomaly in maxillary incisors usually affects esthetic appearance. Therefore, gemination and supernumerary teeth are considered anomalies and need a careful and comprehensive diagnosis and treatment.

Case Description:

This clinical report presents a 10-year-old girl complaining of the esthetic appearance of her anterior maxillary teeth. Clinical and radiographical examinations revealed a maxillary geminated permanent left central incisor and a supplemental supernumerary permanent right lateral incisor. The treatment has been performed in different stages, including preventive, conservative, surgical, and orthodontic treatments. Thus, the large geminated incisor has been restored to its normal shape, and the problem of anterior incisor crowding resolved through alignment.

Conclusion:

Dental anomalies in the anterior segment are common and need time during treatment. Selective grinding for the large geminated incisor and the extraction of the supplemental tooth followed by orthodontic treatment may be the right decisions that a dental practitioner may consider during the management of such cases.
Enhancement of Straw Bale Performance Using Gum Arabic
Authors: Njike Manette , Oyawa Walter O. , Abuodha Silvester O.
Published: December 2021

Background:

The negative impacts of the construction industry are compelling arguments for embracing technology that contributes to carbon footprint reduction and resources conservation. Toward the achievement of objective 9 of the Sustainable Development Goals, the development of new building’s materials like straw bale has advanced in the construction industry. As demonstrated in the literature, straw bale is an eco-friendly material that presents many advantages, like its contribution towards a circular economy. However, it has low compressive strength and displays high displacement under compression load. So far, no attempt has been made in order to enhance the strength of straw bales.

Objective:

This study aimed to develop alternative material to straw bale using chopped straw stems mixed with a binder (gum Arabic) and determine its stress-strain characteristic.

Methods:

The manufacturing process of the new material involved the use of chopped straw and gum Arabic to form straw blocks.

Results:

Results obtained show that the compressive strength of straw block (1.25MPa) is greater than the strength of straw bale (0.02MPa). Also, the average displacement recorded during compression load on straw blocks (29mm) was 2.8 times smaller than the displacement in straw bale (80mm). In terms of shape and size, straw blocks match with conventional materials like cement or compressed block. This will facilitate their use in construction compared to straw bales that require skilled laborers for pre-compression and plastering.

Conclusion:

The use of gum arabic helps in holding straw stems together and forms a compact material with improved strength compared to straw bale. Performance improvement of the characteristics of load-bearing straw bale walls can be addressed by using straw blocks.
role of brand image and customer commitment in mediating service quality towards customer loyalty
Authors: Mahatama Anak Agung Bagus Putra , Wardana Made
Published: December 2021

The purpose of this study is to explain the role of brand image and customer commitment in mediating the effect of service quality on customer loyalty. The population in this study is customers at Kedonganan Village Credit Institution. The purposive sampling method has been used with 130 respondents included. Questionnaires were distributed and the result are analyzed using PLS (Partial Least Square) technique. The results of this study indicate that service quality has a positive and significant effect on brand image, customer commitment, and customer loyalty at Kedonganan Village Credit Institution. There was a significant role of brand image and customer commitment in mediating the effect of service quality on customer loyalty at Kedonganan Village Credit Institution. In order to improve brand image and customer commitment, it is hoped that Kedonganan Village Credit Institution will be able to provide faster service, attractive promotions, and technology improvement to encourage customer loyalty.
Almost the same but not quite Mimicry e Subversão em Youth e Foe de J. M. Coetzee
Authors: Bispo Jéssica
Published: December 2021

This article analyzes, througha postcolonial perspective, the literary works Foeand Youth, both written by J. M. Coetzee. It problematizes the concept of mimicry as presented by Homi K. Bhabha in his essay “Of mimicry and man: The ambivalenceof colonial discourse”. Analyzing the actions of the characters John and Friday, it becomes possible to perceive how they resort to strategies of mimicry and attempt to resist Western discourses of power. Consequently, they present themselves as disruptiveand subversivein a cultural space traditionally imbedded with colonial authority.
“How Does The Never To Be Differ From What Never Was?” The Importance of Dreams and Memory in The Road
Authors: Barbieri Diogo
Published: December 2021

Thehaunting presence of memories and dreams from an unregenerate past society thoroughly permeate the action of Cormac McCarthy’s vision of the post-apocalypse in The Road. Besides the intention of contrasting the barrenness of the world that the protagonists inhabit with the livelyimagery of the old world, the recollections that invade the father’s inner self provide a clash between personal and collective narratives which push him to struggle for survivaland protect his son in an effort to “carry the fire” of humanity. Parallelly, the symbolism of the dreams that we encounterthroughout the novel hold valuable clues that can be accessed to resolve the ambiguous closure to The Road. Inthefirst part of this paper, Iwillrevisitthe field of memory studies to reveal the importance that memory holds as a provider of meaning for life in the apocalypse. The second part of the article develops a theory that absolutely disregards any optimistic reading of the end of the novel, as itpresents us with the possibility that what we read in the last pagesof the bookconstitutes the wish-fulfilment produced by the boy’s dying dream. To investigatethis enticing theory that was furthered by Jacob M. Powning, I will assessthis hypothesis through the lenses of Psychoanalysis. McCarthy’s interest in the psychoanalytic studies, and his fascination with the dream world will help to develop a pertinent proposition that seeks to ultimately resolve the enigmatic Deus Ex-Machina that closes the novel
O Mundo Fora do Lugar: A Trajetória de Degradação do Edifício Holiday Sob a Perspectiva do Espaço Social Bourdieusiano
Authors: Lucena Victor , Leite Julieta
Published: December 2021

À luz de uma sociologia bourdieusiana e suas noções conceituais de espaço social e estilos de vida, este artigo lança uma interpretação reflexiva sobre a trajetória de degradação simbólica de um emblemático prédio construído em 1957 no Recife (Brasil) — o Edifício Holiday. Situado em Boa Viagem, um dos bairros mais ricos da cidade, a edificação é um ícone representativo da chegada da modernidade à capital do estado de Pernambuco e marca um período de importantes modificações na paisagem e nos estilos de vida do Recife. Com 416 pequenas habitações aptas a receber mais de 3.000 moradores, o projeto experimental de apartamentos de veraneio para classes médias e altas na década de 1970 já apresentava sinais de desvalorização em um bairro de trajetória social ascendente. Nosso instrumental analítico, tal como defendido por Bourdieu, recorre à fotografia autoral e a imagens do edifício. Utiliza-se de materiais fotográficos para construir um “antes” e “depois” da desocupação do Holiday, tomando como principal fio condutor da análise ensaios realizados por dois jornalistas recifenses. Os resultados nos auxiliam a entender melhor a dimensão simbólica da habitação no espaço social urbano. Não obstante, o artigo oferece um ponto de inflexão nas discussões acerca da recepção e dos contornos próprios que a modernidade adquiriu em metrópoles do hemisfério sul, como é o caso da capital recifense.
Eficácia e Eficiência nas Associações de Pais e Amigos dos Excepcionais de Minas Gerais
Authors: Bezerra Sérgio Sampaio
Published: December 2021

omo a gestão social é uma discussão atual nos estudos organizacionais, este artigo busca contribuir para compreender e explicar a eficácia e a eficiência nas Associações de Pais e Amigos dos Excepcionais (APAE) de Minas Gerais, Brasil, tomadas do ponto de vista da sua missão estatutária como orientadora de suas práticas. A análise é feita com base na visão dos gestores das APAE sob as três dimensões da sua missão: oferta de serviços, melhoria da qualidade dos serviços e defesa de direitos das pessoas com deficiência intelectual, entendendo-as como sistemas em interação com o meio ambiente externo. Com base num inquérito por questionário aplicado a uma amostra representativa de 199 APAE selecionadas aleatoriamente, foram segmentadas por três clusters pré-definidos segundo a dimensão (porte). Esse questionário foi auto administrado pelos gestores e diretores das APAE, da amostra, sendo composto por uma série de perguntas em função de 54 indicadores presentes nas três dimensões observadas na missão estatutária das APAE. Por forma a analisar a eficácia e a eficiência com base naqueles indicadores, construíram-se índices de eficácia e eficiência. Tendo como referencial a teoria sistêmica e os conceitos de eficácia e eficiência, submeteram-se esses índices a várias técnicas de análise estatística. Os resultados obtidos apontam para existência de homogeneidade estrutural das APAE, independentemente dos seus oito clusters formados com base na distribuição por quartis dos seus diferentes níveis de eficácia e eficiência (baixo, médio, alto e elevado), não tendo sido possível chegar a um modelo quantitativo explicativo dos níveis de eficácia e eficiência das APAE, considerando a influência das variáveis internas e externas com que foram relacionados.
Inclusão Profissional de Trabalhadores com Síndrome de Down na Cidade de São Paulo: Satisfação Pessoal, Produtividade e Relações Sociais no Ambiente de Trabalho
Authors: Casco Ricardo , Andrade Patrícia Ferreira de , Freller Cintia Copit , Saito Gabriel Katsumi , Lima Roberta Cruz
Published: December 2021

O presente artigo objetiva apresentar as discussões acerca dos dados coligidos no âmbito da pesquisa Inclusão Profissional de Trabalhadores com Deficiência Intelectual na Cidade de São Paulo desenvolvida no Laboratório de Estudos sobre o Preconceito, sediado no Instituto de Psicologia da Universidade de São Paulo. A pesquisa, realizada em 2017, objetivou compreender diferentes dimensões referentes à situação de inclusão de 20 jovens com síndrome de Down no mundo laboral. A partir de dados coligidos mediante a realização de observações e entrevistas semiestruturadas junto dos jovens, colegas de trabalho, chefias, familiares e amigos, a pesquisa analisou aspectos concernentes à satisfação pessoal, à produtividade e às relações sociais que se dão no ambiente de trabalho. De modo geral, mesmo diante da tendência generalizada de precarização das condições de trabalho de grande parte da população brasileira, os jovens demonstram satisfação com as atividades laborais, apresentaram produtividade compatível com relação às atividades a eles requeridas e mantiveram boas relações sociais com os seus colegas, chefias e clientes das empresas em que trabalhavam.
Distribución potencial actual y futura de Coffea arabica L. en la subcuenca Decozalapa, Veracruz, México
Authors: Gómez-Tosca Elena G. , Alvarado-Castillo Gerardo , Benítez Griselda , Cerdán-Cabrera Carlos R. , Estrada-Contreras Israel
Published: December 2021

El calentamiento global está provocando variaciones en el clima, lo cual representa una amenaza grave para los sistemas naturales, y México está particularmente expuesto a los efectos del cambio climático. En este sentido, el café es uno de los cultivos más susceptibles a las variaciones meteorológicas, pues requiere de un determinado régimen hidrotérmico para su desarrollo. El objetivo de este trabajo fue modelar la distribución potencial actual y futura de este cultivo ante diferentes escenarios de cambio climático proyectados al 2050 y 2070 en la subcuenca Decozalapa, Veracruz, México, usando el algoritmo Maxlike, a través de tres modelos de circulación general. Se determinó un intervalo de reducción de la distribución potencial de la superficie actual de café (924.5 km2) de entre 4.74 % y 61.67 %, un intervalo de 725 m a 1397 m s.n.m. en la altitud mínima potencial y de 2221 m a 2308 m s.n.m. en la altitud potencial máxima, un aumento posible de la temperatura de entre 1.1 °C y 3.5 °C, lo que implica la pérdida de áreas con idoneidad climática de 4.74% (43.8 km2) a 61.67% (570.1 km2) y cambios en la precipitación de -69 mm a 73 mm. Estas alteraciones sugieren la afectación de la zona cafetalera, incluyendo la posible desaparición de condiciones ambientales adecuadas en cuatro de los principales municipios productores y el desplazamiento del cultivo a latitudes superiores. Finalmente, es arriesgado ignorar los impactos potenciales que el clima presente y futuro puede tener sobre el café, por lo que se requiere tomar medidas de adaptación y mitigación específicas para este cultivo.
Bioethics institutionalisation in the Republics of Kosovo and Albania
Authors: Haliti Valdete , Abdullahu Driton , Rinčić Iva , Muzur Amir
Published: December 2021

The paper tries to briefly present the thorny way of development of bioethics and bioethics institutionalisation in the two countries of South-East Europe – the Republics of Kosovo and Albania – with respect to legal, public-administrative, and societal parameters. Departing from a “European institutionalisation” primer, the article analyses the history and current situations in Kosovo and Albania, taking into account the most prominent individuals and ideas in the domain of bioethics institutionalisation. While Kosovo is missing the ratification of some basic documents (the Oviedo Declaration), Albania has a longer and richer experience in this field, but still lacks the diversity of approach so present and promising in the majority of European countries. Finally, recommendations for bioethical institutionalisation are provided, and the particular role of ethics in the development of public administration in the case of Kosovo is exposed in more detail.
Bioetički aspekti utjecaja teorija zavjere na borbu protiv pandemije COVID-19 u Hrvatskoj
Authors: Kelam Ivica , Dilica Kristina
Published: December 2021

Pojavom pandemije COVID-19 u proljeće 2020. čovječanstvo se našlo pred potpuno novim izazovom - kako reagirati i ponašati se u doba pandemije. Odmah na početku pandemije pojavile su se mnogobrojne teorije zavjere kojima je primarna svrha unijeti nemir i strah u javnost. Globalno je počela utrka za razvojem uspješnog cjepiva koje će okončati pandemiju. Zahvaljujući ogromnom trudu velikog broja znanstvenika i desecima milijardi dolara javnog novca uloženih u istraživanje i razvoj cjepiva, krajem 2020. i početkom 2021. počela je kampanja cijepljenja širom planeta. I prije početka kampanje cijepljenja počele su naveliko kolati teorije zavjere koje su dovodile u sumnju učinkovitost cjepiva. Ove teorije zavjere imale su velik učinak na spremnost na cijepljenje jednog dijela javnosti te su oblikovale njihova mišljenja i stavove. Teorije zavjere, s obzirom na njihovu štetnost za zdravlje ljudi, te činjenice da direktno produžuju trajanje pandemije i pridonose nepotrebnom umiranju od koronavirusa, predstavljaju prvorazredno i aktualno bioetičko pitanje. U radu ćemo prikazati navedene tvrdnje teoretičara zavjere, njihov utjecaj na građane Hrvatske te motive zbog kojih gotovo polovina hrvatskih građana oklijeva ili se uopće ne želi cijepiti.
Clinical solutions performed in non-conventional settings
Authors: Benevides Magalhães Braga Tatiana , Alves de França Demétrius , Gonçalves Farinha Marciana , de Magalhães  Gemino Alessandro , Penteado Cabral Bárbara
Published: December 2021

This paper presents the Brazilian specificities of the development of its public health and social assistance policies since the re-democratization process in the 1980s until today. Besides, it presents a wide range of conflicts between the economic interests and the political activism accountable for the advances of the public policies implementation. This evolution is presented as a subsidy to the reader’s understanding of the development of a clinical solution for non-conventional settings specific to the Brazilian social and economic reality. Successful clinical experiences in health and social assistance based on phenomenology are presented, not only for diagnosis purposes, namely for understanding the people, for the context in the question, as well as the successful management development. The first case describes the provision of a peripatetic group therapy service, prior as a walking clinical practice, where the notion of territoriality and the dynamics of group interaction facilitate the understanding of the patients, while the intrinsic condition of the work also facilitates the establishment of transferential relationships. The second case describes the complexity of social welfare policy challenges through the clinical intervention while presenting a family in a social and economic vulnerability context.
Kriza tijela
Authors: Novaković Vanja , Todorović Tanja , Rupčić Kelam Darija , Janeš Luka
Published: December 2021

Višestruke su posljedice krize na ljudsku psihu i tijelo, a u ovom radu evaluirat ćemo na koji se način ponajprije umjetnici i filozofi nose s krizama u društvu te kolika je snaga i propulzivnost kreativnog umjetničkog izražavanja pri suočavanju s aktualnom pandemijskom krizom. Na primjerima avangardnih pokreta uočavamo da su umjetnici u doba kriza zauvijek promijenili formalne karakteristike umjetnosti, umjetničkog djela, ali također i samo razumijevanje umjetničkog procesa. Povijesnim osvrtom izvodimo hipotezu da su pojedini umjetnički pravci u doba aktualne krize uspjeli opstati na periferiji upravo zbog duha avangarde koji nose u sebi. Filozofija, pak, reflektira krizu sinkrono s novim umjetničkim pokretima, te se čini da i „postmoderna umjetnost“ i fenomenologija idu usuprot same realnosti. U diskurzivni centar rada postavljamo analizu samog tijela koje je, postavljamo hipotezu, tradicionalno bivalo zanemareno i često stavljano na najnižu poziciju ontološke ljestvice pri mnogobrojnim filozofskim pokušajima kroz povijest. Zaključno, nastojat ćemo adekvatno argumentirati temeljnu hipotezu članka da je tijelo samo ekspresija krize, a da njezinu dublju osnovu valja tražiti u ljudskoj psihi i strukturama subjektivnosti koje su je uvjetovale. Pri čemu nastojimo „rasplesati“ i „raživotiti“ digitalnu tehničku statiku aktualnog stanja socijalne distance uzrokovane pandemijskom krizom, prilazeći joj kao svojevrsnoj sublimaciji povijesnih kriza koje su joj prethodile.
From the Editors
Authors: Zitser Ernest , Collis Robert
Published: December 2021

Editorial
Parental Perspectives on the Implementation of House Dust Mite Avoidance Measures for Children with House Dust Mite Sensitization
Authors: Gür Çetinkaya Pınar , Soyak Aytekin Elif , Akarsu Ayşegül , Şahiner Ümit Murat , Şekerel Bülent Enis , Soyer Özge
Published: December 2021

ABSTRACTObjective: The avoidance of house dust mite (HDM) is crucial in the management of HDM allergies. We aimed to demonstrate the implementation and perspective of the parents whose children had HDM allergy/sensitization to HDM avoidance measures. Materials and Methods: Parents of the patients with HDM sensitization were interviewed via telephone questionnaires.Results: One hundred and three patients with asthma (73.8%), allergic rhinitis (AR) (77.7%) and/or atopic dermatitis (AD) (29.1%) aged four to 18 years were included in the study. Seventy-one patients had multiple allergic diseases (68.9%). Of the parents, 39.8% fully adhered to HDM avoidance measures, and their education status was as follows: 41.5% illiterate/elementary/middle school, 31.7% high school, and 26.8% associate’s degree/university. In addition, 32.2% of the mothers who were partially adherent (n=62) were illiterate or had graduated from elementary/middle school, 33.9% had graduated from high school, and 33.9% had an associate’s degree or had graduated from university. Forty-one (39.8%) mothers were working, and most of them (61%) had graduated from university or had an associate’s degree. Nearly half of the mothers who were partially adherent to HDM measures were working (n=32). In the multivariate analysis, the risk factors for partial adherence to measures was to be a working mother [OR:4.072, 95%CI: 1.350-12.882, p=0.013] and to have the belief that the measures were useless [OR:4.886, 95%CI: 1.499-15.923, p=0.008]. However, no relationship was shown between adherence to the measures and the severity of AR or AD, asthma control status and having multiple allergic diseases.Conclusion: Full adherence to HDM avoidance measures was considerably dependent on the mothers’ working status and belief in the ineffectiveness of the measures whereas there was no relationship to the severity of allergic diseases. This study also revealed how the education status of the mothers affected the adherence to allergen avoidance measures in real life.Keywords: Children, Dermatophagoides pteronyssinus,Dermatophagoides farinae, house dust mites, avoidance measures, parents, pediatrics, questionnaire
Allergic Contact Dermatitis to Temporary Black Henna Tattoo Due to Sensitization to Para-Phenylenediamine
Authors: DIBEK MISIRLIOGLU Emine , TANIDIR Merve , BUYUKTIRYAKI3 Betul , KANIK YUKSEK Saliha , SAHINER Neriman , GUVENIR Hakan , AZKUR Dilek , KOCABAS Can Naci
Published: December 2021

The fashion for temporary “black henna tattoo” is becoming increasingly more common among young adults and teens. An adolescent case with itching, erythema, edema, and inflammatory discharge on the right forearm two days after a temporary tattoo application is presented in this report. To determine the contact sensitizer, a patch test was performed one month after the end of the treatment. A bullous strong positive reaction (3+) was observed against para-phenylenediamine at the 48th and 72nd hours of evaluation after the application. Despite the common belief that henna tattoo application is harmless, the ingredients used in henna tattoo especially para-phenylenediamine can lead to allergenic reactions that can even be severe.Keywords: Adolescent, contact dermatitis, para-phenylenediamine
Atopy and Allergic Diseases Have No Impact on the Severity of COVID-19
Authors: Can Ali , KARABACAK Deniz Eyice , TÜZER Can , ALİBEYOĞLU2 Alpay Medet , KÖSE Murat , DEMİR Semra , BÜYÜKÖZTÜRK Suna , ÇOLAKOĞLU Bahauddin , GELİNCİK Asli
Published: December 2021

Objective: The clinical features of COVID-19 range from asymptomatic disease to severe pneumonia or even death. Therefore, many researchers have investigated the factors that could affect the severity of COVID-19. We aimed to assess the impact of aero-allergen sensitization and allergic diseases on the severity of COVID-19. Materials and Methods: We included 60 adult patients with symptomatic COVID-19 and allocated them into two groups equal in number as having severe and non-severe COVID-19. We evaluated the demographic features and allergic diseases in addition to clinical, laboratory and radiological findings of COVID-19. Skin prick tests (SPTs) with common aero-allergens, serum total IgE levels and blood eosinophil counts were evaluated 3 months after the patient’s recovery from COVID-19.Results: The mean age of the patients was 52 ± 11 years and 73.3% of the patients were male. There was no significant difference between the two groups in terms of age, gender, smoking habits, obesity and comorbidities. Although the frequency of sensitization to aero-allergens and the allergic diseases were similar, the history of allergic diseases in the family was higher in the severe group (p<0.001). The polysensitization in SPTs was associated with the presence of a cytokine storm during the infection (p=0.02). Total IgE levels and blood eosinophil counts were not significantly different between the two groups.Conclusion: The presence of atopy or allergic diseases does not seem to be related to the severity of COVID-19. However, polysensitization and a family history of allergic diseases are more prominent in those having a cytokine storm and severe COVID-19, respectively. Keywords: COVID-19, atopy, allergic disease, aero-allergen sensitization, cytokine storm