bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Physical Activity Restrictions on Health-Related Fitness in Children with Congenital Heart Disease
Authors: Blanchard Joel , McCrindle Brian W. , Longmuir Patricia E.
Published: April 2022

Children with congenital heart disease (CHD) are often restricted from some types of physical activity (PA) despite the lack of evidence regarding the need to restrict recreational PA, apart from those with rhythm disorders. This study retrospectively investigated the associations between parent-reported activity restrictions (on-going need to restrict exertion, body contact or competition) and measures of health-related fitness among 236 children (8.2 ± 2.1 years, range 4–12 years) treated for single ventricle (n = 104), tetralogy of Fallot (n = 48), transposition of the great arteries (n = 47) or atrial septal defect (n = 37). Body mass index (BMI), moderate-to-vigorous physical activity (MVPA; 7 day accelerometry), strength, flexibility, and movement skill assessment results were collected from the baseline assessment research records for two studies completed in Ontario, Canada. A subset of 62 children also had physician-reported activity restrictions. Regression models empirically tested the goodness of fit between the dependent and independent variables. Participants with body contact restrictions from both parents and physicians had significantly higher BMI z-scores (0.23 ± 1.19 vs. −0.32 ± 0.85; t = 2.55; p = 0.04 and 0.66 ± 1.33 vs. −0.02 ± 0.98; t = 2.25; p = 0.02 for CDC and WHO scores, respectively). Otherwise, BMI z-score was not associated with patient variables (p > 0.36; sex, cardiac diagnosis, age, or activity restriction). Children with any type of parent-reported restriction (0.98 ± 2.06 vs. −0.08 ± 1.99; t = 3.77; p = 0.0002) were less flexible. Movement skill (TGMD-2) scores were 50% lower (25.1 ± 31.2 vs. 52.6 ± 28.6; F = 6.93; p = 0.009) among children with parent-reported competitive sport restrictions. Weekly MVPA (p > 0.18) and strength (p > 0.05) were not associated with activity restriction. Children whose parents reported PA restrictions were less flexible, and had decreased movement skill and increased BMI z-scores if the restrictions impacted competitive sport or body contact, respectively. Future research is recommended to confirm these results among larger samples of children who have both parent- and physician-specified PA restrictions.
Obesity in Polish Children and Parents’ Perception of Their Children’s Weight Status: The Results of the SOPKARD-Junior Study
Authors: Suligowska Klaudia , Buczny Jacek
Published: April 2022

One way to counteract the spread of obesity in children is its early recognition by parents. Therefore, the aim of this study was to investigate whether parents’ perception of their children’s BMI category was consistent with their actual BMI assessment and to determine potential influential factors. The study was conducted as part of the “A program for the early detection of risk factors for lifestyle diseases SOPKARD-Junior” (SOPKARD-Junior), a preventive health program implemented in public elementary schools from 2017 to 2019. The results from 381 children with a mean age of 11.67 (SD = 1.52) were analyzed. Height and weight were measured and BMI was calculated. Surveys were conducted to assess parents’ perceptions of their child’s weight, along with their sociodemographic status. Nearly one in three parents were unable to correctly identify their children’s weight; 25.0% underestimated it, and 6.0% overestimated it. Underestimation was observed along with an increase in the children’s BMI weight category, with as many as 57.1% of parents of obese children misclassifying their weight. The child’s BMI was the only significant predictor of incorrect assessment. Polish parents cannot properly assess their children’s BMI, especially when their child is overweight or obese. In children, weight and height measurements should be taken regularly, rather than allowing weight category to be dependent upon parental weight assessments.
Impacts of Extreme Climate Events on Future Rice Yields in Global Major Rice-Producing Regions
Authors: Zhao Weixing , Chou Jieming , Li Jiangnan , Xu Yuan , Li Yuanmeng , Hao Yidan
Published: April 2022

Under the dual impacts of climate change and COVID-19, there are great risks to the world’s food security. Rice is one of the three major food crops of the world. Assessing the impact of climate change on future rice production is very important for ensuring global food security. This article divides the world’s main rice-producing regions into four regions and uses a multivariate nonlinear model based on historical economic and climatic data to explore the impacts of historical extreme climatic events and economic factors on rice yield. Based on these historical models, future climatic data, and economic data under different shared socioeconomic pathways (SSPs), the yields of four major rice-producing regions of the world under different climate change scenarios (SSP126, SSP245, and SSP585) are predicted. The research results reveal that under different climate change scenarios, extreme high-temperature events (Tx90p) and extreme precipitation events (Rx5day, R99pTOT) in the four major rice-producing regions have an upward trend in the future. Extreme low-temperature events (Tn10p) have a downward trend. In the rice-producing regions of Southeast Asia and South America, extreme precipitation events will increase significantly in the future. The prediction results of this model indicate that the rice output of these four major rice-producing regions will show an upward trend in the future. Although extreme precipitation events will have a negative impact on rice production, future increases in rice planting areas, economic development, and population growth will all contribute to an increase in rice production. The increase in food demand caused by population growth also brings uncertainty to global food security. This research is helpful for further understanding climate change trends and risks to global rice-production areas in the future and provides an important reference for global rice-production planning and risk management.
The COVID-19 Pandemic: Public Health Responses in Sub-Saharan Africa
Authors: Murewanhema Grant , Dzinamarira Tafadzwa
Published: April 2022

The World Health Organisation declared the ongoing COVID-19 global health challenge a pandemic in March 2020. Since then, countries across the globe have implemented different public health control strategies—including global vaccination programs—in attempts to mitigate the further transmission of severe acute respiratory syndrome coronavirus 2. However, to date, the virus has continued to spread rapidly despite these interventions. Countries across sub-Saharan Africa have implemented variable control strategies to combat the pandemic; however, despite the continent being among the least affected in terms of direct case burden, morbidity, and mortality, it has experienced marked socioeconomic disruption. Therefore, economic resuscitation is an urgent priority. The continent is vastly underrepresented in the body of scientific evidence due to limited research resources, testing capacity and genomic surveillance leading to empirical responses or responses guided by evidence from elsewhere. To inform the ongoing pandemic, and to prepare for the future, this Special Issue calls for manuscripts on global COVID-19 responses, and encourages researchers and stakeholders from resource-limited settings, particularly from sub-Saharan Africa, to share their COVID-19 public health responses. Areas to be covered include, but are not limited to, surveillance, case management, infection prevention and control, risk communication and community engagement, logistics, laboratory, ports of entry, and co-ordination. Manuscripts including primary research, viewpoints/perspectives, and comprehensive literature reviews are all welcome.
Development and Evaluation of Integrated Chrono-Nutrition Weight Reduction Program among Overweight/Obese with Morning and Evening Chronotypes
Authors: Mazri Fatin Hanani , Manaf Zahara Abdul , Shahar Suzana , Mat Ludin Arimi Fitri , Abdul Basir Siti Munirah
Published: April 2022

This paper describes the development of an integrated chrono-nutrition weight reduction program and the evaluation of the attendance, retention, satisfaction and compliance towards the chrono-nutrition components among morning and evening chronotypes for overweight/obese non-shift workers. The present study was conducted in two phases: Phase I was composed of needs assessments on the chronotypes’ dietary patterns and chrono-nutrition through a scoping review and integrating the chrono-nutrition components (temporal eating pattern, meal timing and sleeping habits) alongside the existing weight reduction module, SLIMSHAPE™. Phase II consisted of a feasibility study to evaluate the integrated chrono-nutrition weight reduction program (SLIMSHAPE™ Chrono). A total of 91 overweight/obese non-shift workers participated in the 12-week weight reduction program (Age: 39.6 ± 6.3 years; 74.7% women; BMI: 31.2 ± 4.5 kg/m2). Low attrition rate was recorded, with 85 participants (93.4%) completing the pre- and post-intervention assessments. Overall, morning and evening chronotypes had increased their % energy intake in the early eating window (MT: 64.8 vs. 67.2%, ET: 62.7 vs. 65.6%, Mean difference (MD): 2.8, 95%CI: 0.3, 5.1, p = 0.028) and reduced their intake in the late eating window (MT: 35.2 vs. 32.8%, ET: 37.3 vs. 34.4%, MD: −2.8, 95%CI: −5.1, −0.3, p = 0.028) and earlier midpoint of eating (MT: 14:02 vs. 13:49; ET: 14:27 vs. 14:18, 95%CI: −0.4, −0.02, p = 0.029) and had a reduced night eating syndrome score (MT: 10.0 vs. 8.9; ET: 10.7 vs. 8.9, MD: −1.5, 95%CI: −2.5, −0.5, p = 0.004). There was no significant change in the first (MT: 08:12 vs. 08:04, ET: 08:24 vs. 08:22, MD: −0.1, 95%CI: −0.2, 0.03, p = 0.170) and last mealtime (MT: 19:52 vs. 19:33, ET: 20:29 vs. 20:14, MD: −0.3, 95%CI: −0.6, −0.04, p = 0.081), eating duration (MT: 11.7 vs. 11.5 h, ET: 12.1 vs. 11.9 h, MD: −0.2, 95%CI: −0.6, 0.2, p = 0.251) and the elapse time between sleep onset and last meal (MT: 3.1 vs. 3.5 h, ET: 3.5 vs. 3.2 h, MD: 0.1, 95%CI: −0.3, 0.4, p = 0.678). In terms of sleep, evening chronotypes increased their sleep duration (MD: 0.8 h, 95% CI: 0.4, 1.2, p < 0.001) and reduced social jetlag (MD: 19 min, 95% CI: 1.7, 36.3, p = 0.031) post-intervention compared to morning chronotypes. The integrated chrono-nutrition weight reduction program among morning and evening chronotypes improved the temporal pattern of energy intake, meal timing, night eating syndrome and sleep habits post-intervention. The chrono-nutrition practice could be a potentially modifiable behavior as an adjunct strategy in weight management.
Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism
Authors: Santos-Terra Júlio , Deckmann Iohanna , Carello-Collar Giovanna , Nunes Gustavo Della-Flora , Bauer-Negrini Guilherme , Schwingel Gustavo Brum , Fontes-Dutra Mellanie , Riesgo Rudimar , Gottfried Carmem
Published: April 2022

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by several alterations, including disorganized brain cytoarchitecture and excitatory/inhibitory (E/I) imbalance. We aimed to analyze aspects associated with the inhibitory components in ASD, using bioinformatics to develop notions about embryonic life and tissue analysis for postnatal life. We analyzed microarray and RNAseq datasets of embryos from different ASD models, demonstrating that regions involved in neuronal development are affected. We evaluated the effect of prenatal treatment with resveratrol (RSV) on the neuronal organization and quantity of parvalbumin-positive (PV+), somatostatin-positive (SOM+), and calbindin-positive (CB+) GABAergic interneurons, besides the levels of synaptic proteins and GABA receptors in the medial prefrontal cortex (mPFC) and hippocampus (HC) of the ASD model induced by valproic acid (VPA). VPA increased the total number of neurons in the mPFC, while it reduced the number of SOM+ neurons, as well as the proportion of SOM+, PV+, and CB+ neurons (subregion-specific manner), with preventive effects of RSV. In summary, metabolic alterations or gene expression impairments could be induced by VPA, leading to extensive damage in the late developmental stages. By contrast, due to its antioxidant, neuroprotective, and opposite action on histone properties, RSV may avoid damages induced by VPA.
Spectroscopic and Molecular Docking Investigation on the Interaction of Cumin Components with Plasma Protein: Assessment of the Comparative Interactions of Aldehyde and Alcohol with Human Serum Albumin
Authors: Ali Mohd Sajid , Rehman Md Tabish , Al-Lohedan Hamad , AlAjmi Mohamed Fahad
Published: April 2022

The interaction of the important plasma protein, human serum albumin (HSA), with two monoterpenes found in cumin oil, i.e., cuminaldehyde (4-isopropylbenzaldehyde) and cuminol (4-isopropylbenzyl alcohol), was studied in this paper. Both experimental and computational methods were utilized to understand the mechanism of binding. The UV absorption profile of HSA changes in the presence of both cuminaldehyde and cuminol, due to the interaction between HSA with both monoterpenes. The intrinsic fluorescence intensity of HSA was also quenched on the sequential addition of both ligands, due to change in the microenvironment of the fluorophore present in the former. Quenching of HSA by cuminaldehyde was much higher in comparison to that in the presence of cuminol. Fluorescence quenching data were analyzed using modified Stern-Volmer and Lineweaver-Burk methods, which suggested that the binding mechanism was of a static type for both ligands. In both cases, the binding was favored by the domination of hydrophobic as well as hydrogen bonding/Van der Waals forces. Both ligands partially unfolded the secondary structure of HSA, although the effect of cuminaldehyde was more pronounced, as compared to cuminol. The preferred binding site of cuminaldehyde and cuminol inside HSA was also the same; namely, drug binding site 1, located in subdomain IIA. The study showed that cuminaldehyde binds strongly with albumin as compared to its alcohol counterpart, which is due to the more hydrophobic nature of the former.
Plant Nutrition: Physiological and Metabolic Responses, Molecular Mechanisms and Chromatin Modifications
Authors: Hafiz Fatema Binte , von Tucher Sabine , Rozhon Wilfried
Published: April 2022

Plant growth and crop yield highly depend on the availability of all required nutrients, ideally in well-balanced ratios [...]
Magnetic Fluorescent Quantum Dots Nanocomposites in Food Contaminants Analysis: Current Challenges and Opportunities
Authors: Xiong Jincheng , Zhang Huixia , Qin Linqian , Zhang Shuai , Cao Jiyue , Jiang Haiyang
Published: April 2022

The presence of food contaminants can cause foodborne illnesses, posing a severe threat to human health. Therefore, a rapid, sensitive, and convenient method for monitoring food contaminants is eagerly needed. The complex matrix interferences of food samples and poor performance of existing sensing probes bring significant challenges to improving detection performances. Nanocomposites with multifunctional features provide a solution to these problems. The combination of the superior characteristics of magnetic nanoparticles (MNPs) and quantum dots (QDs) to fabricate magnetic fluorescent quantum dots (MNPs@QDs) nanocomposites are regarded as an ideal multifunctional probe for food contaminants analysis. The high-efficiency pretreatment and rapid fluorescence detection are concurrently integrated into one sensing platform using MNPs@QDs nanocomposites. In this review, the contemporary synthetic strategies to fabricate MNPs@QDs, including hetero-crystalline growth, template embedding, layer-by-layer assembly, microemulsion technique, and one-pot method, are described in detail, and their advantages and limitations are discussed. The recent advances of MNPs@QDs nanocomposites in detecting metal ions, foodborne pathogens, toxins, pesticides, antibiotics, and illegal additives are comprehensively introduced from the perspectives of modes and detection performances. The review ends with current challenges and opportunities in practical applications and prospects in food contaminants analysis, aiming to promote the enthusiasm for multifunctional sensing platform research.
Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase
Authors: Koike Hiroshi , Nishida Yoshihiro , Shinomura Tamayuki , Ohkawara Bisei , Ohno Kinji , Zhuo Lisheng , Kimata Koji , Ushida Takahiro , Imagama Shiro
Published: April 2022

KIAA1199 has a strong hyaluronidase activity in inflammatory arthritis. This study aimed to identify a drug that could reduce KIAA1199 activity and clarify its effects on inflammatory arthritis. Rat chondrosarcoma (RCS) cells were strongly stained with Alcian blue (AB). Its stainability was reduced in RCS cells, which were over-expressed with the KIAA1199 gene (RCS-KIAA). We screened the drugs that restore the AB stainability in RCS-KIAA. The effects of the drug were evaluated by particle exclusion assay, HA ELISA, RT-PCR, and Western blotting. We further evaluated the HA accumulation and the MMP1 and three expressions in fibroblast-like synoviocytes (FLS). In vivo, the effects of the drug on symptoms and serum concentration of HA in a collagen-induced arthritis mouse were evaluated. Ipriflavone was identified to restore AB stainability at 23%. Extracellular matrix formation was significantly increased in a dose-dependent manner (p = 0.006). Ipriflavone increased the HA accumulation and suppressed the MMP1 and MMP3 expression on TNF-α stimulated FLS. In vivo, Ipriflavone significantly improved the symptoms and reduced the serum concentrations of HA. Conclusions: We identified Ipriflavone, which has inhibitory effects on KIAA1199 activity. Ipriflavone may be a therapeutic candidate based on its reduction of KIAA1199 activity in inflammatory arthritis.
2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule
Authors: Buzun Kamila , Gornowicz Agnieszka , Lesyk Roman , Kryshchyshyn-Dylevych Anna , Gzella Andrzej , Czarnomysy Robert , Latacz Gniewomir , Olejarz-Maciej Agnieszka , Handzlik Jadwiga , Bielawski Krzysztof , Bielawska Anna
Published: April 2022

It was established that the synthesis of hybrid molecules containing a thiazolidinone and a (2Z)-2-chloro-3-(4-nitrophenyl)prop-2-ene structural fragments is an effective approach for the design of potential anticancer agents. Given the results of the previous SAR-analysis, the aim of the study was to synthesize a novel 4-thiazolidinone derivative Les-3331 and investigate its molecular mechanism of action in MCF-7 and MDA-MB-231 breast cancer cells. The cytotoxic properties and antiproliferative potential of Les-3331 were determined. The effect of the tested compound on apoptosis induction and mitochondrial membrane potential was checked by flow cytometry. ELISA was used to determine caspase-8 and caspase-9, LC3A, LC3B, Beclin-1, and topoisomerase II concentration. Additionally, PAMPA, in silico or in vitro prediction of metabolism, CYP3A4/2D6 inhibition, and an Ames test were performed. Les-3331 possesses high cytotoxic and antiproliferative activity in MCF-7 and MDA-MB-231 breast cancer cells. Its molecular mechanism of action is associated with apoptosis induction, decreased mitochondrial membrane potential, and increased caspase-9 and caspase-8 concentrations. Les-3331 decreased LC3A, LC3B, and Beclin-1 concentration in tested cell lines. Topoisomerase II concentration was also lowered. The most probable metabolic pathways and no DDIs risk of Les-3331 were confirmed in in vitro assays. Our studies confirmed that a novel 4-thiazolidinone derivative represents promising anti-breast cancer activity.
The Role of Cytoskeleton Revealed by Quartz Crystal Microbalance and Digital Holographic Microscopy
Authors: Braidotti Nicoletta , do R. B. F. Lima Maria Augusta , Zanetti Michele , Rubert Alessandro , Ciubotaru Catalin , Lazzarino Marco , Sbaizero Orfeo , Cojoc Dan
Published: April 2022

The connection between cytoskeleton alterations and diseases is well known and has stimulated research on cell mechanics, aiming to develop reliable biomarkers. In this study, we present results on rheological, adhesion, and morphological properties of primary rat cardiac fibroblasts, the cytoskeleton of which was altered by treatment with cytochalasin D (Cyt-D) and nocodazole (Noc), respectively. We used two complementary techniques: quartz crystal microbalance (QCM) and digital holographic microscopy (DHM). Qualitative data on cell viscoelasticity and adhesion changes at the cell–substrate near-interface layer were obtained with QCM, while DHM allowed the measurement of morphological changes due to the cytoskeletal alterations. A rapid effect of Cyt-D was observed, leading to a reduction in cell viscosity, loss of adhesion, and cell rounding, often followed by detachment from the surface. Noc treatment, instead, induced slower but continuous variations in the rheological behavior for four hours of treatment. The higher vibrational energy dissipation reflected the cell’s ability to maintain a stable attachment to the substrate, while a cytoskeletal rearrangement occurs. In fact, along with the complete disaggregation of microtubules at prolonged drug exposure, a compensatory effect of actin polymerization emerged, with increased stress fiber formation.
Cell Senescence and Central Regulators of Immune Response
Authors: Lunin Sergey M. , Novoselova Elena G. , Glushkova Olga V. , Parfenyuk Svetlana B. , Novoselova Tatyana V. , Khrenov Maxim O.
Published: April 2022

Pathways regulating cell senescence and cell cycle underlie many processes associated with ageing and age-related pathologies, and they also mediate cellular responses to exposure to stressors. Meanwhile, there are central mechanisms of the regulation of stress responses that induce/enhance or weaken the response of the whole organism, such as hormones of the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic and parasympathetic systems, thymic hormones, and the pineal hormone melatonin. Although there are many analyses considering relationships between the HPA axis and organism ageing, we found no systematic analyses of relationships between the neuroendocrine regulators of stress and inflammation and intracellular mechanisms controlling cell cycle, senescence, and apoptosis. Here, we provide a review of the effects of neuroendocrine regulators on these mechanisms. Our analysis allowed us to postulate a multilevel system of central regulators involving neurotransmitters, glucocorticoids, melatonin, and the thymic hormones. This system finely regulates the cell cycle and metabolic/catabolic processes depending on the level of systemic stress, stage of stress response, and energy capabilities of the body, shifting the balance between cell cycle progression, cell cycle stopping, senescence, and apoptosis. These processes and levels of regulation should be considered when studying the mechanisms of ageing and the proliferation on the level of the whole organism.
Fibrin Strands Will Grow from Soluble Fibrin and Hang Up in an In Vitro Microcirculatory Viscoelastic Model: Is This a Major Cause of COVID-19 Associated Coagulopathy?
Authors: Bull Brian S. , Hay Karen L. , Herrmann Paul C.
Published: April 2022

Viscoelastic testing (VET) by both TEG and ROTEM has demonstrated hypercoagulability early in corona virus disease 2019 (COVID-19) associated coagulopathy (CAC). Additional VET studies demonstrated fibrinolytic shutdown late in a majority of severely ill COVID-19 patients with an associated elevation of d-dimer. Elevated d-dimer confirms that coagulation, followed by fibrinolysis, has occurred. These findings imply that, during CAC, three enzymes—thrombin, Factor XIIIa and plasmin—must have acted in sequence. However, limitations in standard VET analyses preclude exploration of the earliest phases of clot induction, as well as clot formation and clot dissolution in flowing blood. Herein, we describe a novel method illuminating aspects of this unexplored area. In addition, we created an in vitro blood flow model in which the interactions of thrombin, Factor XIII and plasmin with fibrinogen can be studied, allowing the determination of soluble fibrin (SF), the highly unstable form of fibrin that precedes the appearance of a visible clot. This model allows the determination of the SF level at which fibrin microclots begin to form.
SYNTAXONOMY OF ANTROPOGENIC FOREST COMMUNITIES OF THE LEFT BANK FOREST-STEPPE OF UKRAINE
Authors: Davydov D.
Published: April 2022

Results of the phytosociological research of antropogenic forest communities of the Left Bank Forest-Steppe of Ukraine were summarized in this paper. Author found that the names Robinietea pseudoacaciae Jurko ex Hadač & Sofron 1980 and Chelidonio majoris-Robinietalia pseudoacaciae Jurko ex Hadač & Sofron 1980 widely accepted by various authors were invalidly published in 1980 so both these names have been validated to preserve their current use. The class Robinietea pseudoacaciae Jurko ex Davydov cl. nov. includes the one order Chelidonio majoris-Robinietalia pseudoacaciae Jurko ex Davydov ord. nov., two alliances (Balloto-nigrae-Robinion pseudoacaciae and Chelidonio majoris-Robinion pseudoacaciae) and six associations. Three associations are new: the first of them is Chelidonio majoris-Pinetum sylvestris (Gorelov 1997) ass. nova et stat. nov., the name in a new rank proposed for previously descibed subassociation Chelidonio-Robinietum pinetosum sylvestris Gorelov 1997 (the vegetation of pine forest plantations), the second one is Elymo repentis-Robinietum pseudoacaciae ass. nova, the correct name against invalidly published name Elytrigio repentis-Robinietum pseudoacaciae Smetana 2002, the third association is Poo angustifoliae-Fraxinetum pennsylvanicae ass. nova including for the vegetation of forest plantations dominated by Fraxinus penssylvanica. Nomenclatural types, original publications, data about chorology and ecology of studied communities are indicated for all syntaxa.
FLORISTIC FINDINGS ON THE TERRITORY OF NPP «NYZHNYODNIPROVSKY» (KHERSON REGION)
Authors: Davydova A. , Dzerkal V.
Published: April 2022

The National Nature Park «Nyzhnyodniprovsky» is located in the south of Ukraine in the Kherson region. According to a preliminary analysis, the flora of the NNP «Nyzhnyodniprovsky» has 516 species of higher vascular plants belonging to 313 genera and 100 families During the expeditionary research on the territory of Nizhnedneprovsky National Park in 2019-2020, an inventory of flora was conducted and species that were not previously listed for the territory of the national nature park were identified – 58 species of higher vascular plants belonging to 42 genera and 22 families. Of the 58 species, 19 are listed firstly for territory of NNP, others are noted in the literature, 32 of them are noted for the lower reaches of the Dnieper and seven – for the modern territory of NNP. From the total number of locations found 15 species were recorded in the steppe areas.
PHYTOSOZOLOGICAL CHARACTERISTICS OF DRABYNIVKA BOTANICAL RESERVE (POLTAVA OBLAST, UKRAINE)
Authors: Smolar N. , Khannanova O. , Shkura T.
Published: April 2022

The article presents the results of phytosozological assessment of the «Drabynivka» Botanical Reserve territory (Kobeliaky district, Poltava oblast). The flora of the Nature Reserve includes 488 species from 294 genera, 80 families, 44 orders, three classes and two divisions. The rarity is made up of 38 species, 37 of which have sozological status, and one (Stachys germanica) requires its assignment. Nine species are included into the Red Book of Ukraine (Adonis vernalis, Adonis wolgensis, Anacamptis palustris, Bulbocodium versicolor, Fritillaria ruthenica, Tulipa quercetorum, Ornithogalum boucheanum, Crocus reticulatus, Stipa capillata). 27 species are regionally rare and are therefore protected within Poltava oblast limits. One of the species is included in the CITES Convention Annex (Adonis vernalis), another one is in the World Red List (Trinia kitaibelii), one species requires preservation at the regional level (Stachys germanica).Stipa capillata groups are included in the Green Book of Ukraine. The article presents the state of distribution and general characteristics of rare flora species coenopopulations state in the Reserve. Ecological risks for phytodiversity preservation have been identified. The directions of the Reserve territory optimization and expansion of its area for full-rate functioning as a key territory of the regional ecological network local eco-corridor are outlined.
COMPARATIVE ECOLOGYCAL ANALYSIS OF THE INFLUENCE OF SEASONS ON THE BALANCE OF THE AUTONOMOUS NERVOUS SYSTEM AND FUNCTIONAL HEALTH OF WOMEN OF DIFFERENT AGES
Authors: Yermishev O. , Batsylyeva O. , Shumigay I.
Published: April 2022

Some functions of the human body and human health are characterized by their change over the seasons. The autonomic nervous system (ANS) plays a leading role in adaptation processes. The capacity of the body’s adaptation reserves, efficiency and choice of adaptation strategy, adequate physiological support and maintenance of homeostasis depend on the state of the ANS. With the help of Functional-vegetative diagnostics according to the method of V. Makats, which is officially approved by the Ministry of Health of Ukraine, we examined 3439 women of different ages who underwent sanatorium treatment in Ukraine. The bioelectrical activity of 12 symmetrical pairs of functionally active zones of the skin (24 PHASES), 12 on the arms and 12 on the legs, which reflect the functional activity of the sympathetic and parasympathetic nervous systems, was studied. It has been shown that the change of seasons leads to changes in functional activity and homeostasis of the organism. In seasonal indicators of the functional systems activity duplicate the line of the norm, differing in amplitude and having the same direction. The study of functional health showed that this indicator is most stable in the group of girls aged 12–15 years old, regardless of the season. In the group of girls aged 3-6 years old, the largest amplitude of fluctuations in functional health is 35.3–77.7%. In the group of adult women, a reduced ability to adapt was found, which was manifested in all seasons of the year and is evidenced by a reduced number of people in the area of functional balance and a significant increase in the area of parasympathetic activity. Despite the unequal nature of changes in the activity of functional systems under the influence of different seasons of the year on female groups of different ages, increased activity of functional systems is compensated by the suppression of other ones and autonomic coefficient remains within normal 0.95–1.05. In a healthy body, changes in physiological processes and functional activity of systems under the influence of such a factor as the change of seasons are easily compensated. A special role belongs to the autonomic nervous system, the activity of which provides an adequate response of the organism to the influence of environmental factors, which indicates the species evolutionary adaptation of man to seasonal changes in climatic conditions.
ROLE OF PROFESSOR S. O. ILLICHEVSKYI IN BOTANIC AND NATURE PROTECTING RESERCHES DEVELOPMENT IN UKRAINE
Authors: Samorodov V. , Khalymon O.
Published: April 2022

For the first time life and professional impact of candidate of biological sciences, professor, prominent Ukrainian botanist Serhii Olimpiyovych Illichevskyi (1895-1959?) are most completely described. His impact to the development of phenology, dendrology, flora and completing range of herbariums is analyzed. Authors made conclusion about key role of the scientist in nature protection, forming of preserved fund of Poltava Region (1930s) on the basis of gathered material. His multifold activity in exploring phyto-multiformity of Chernihiv, Kharkiv, Kherson, Donetsk Regions and Crimea is also observed. Data about S. O. Illichevskyi’s work in some botanical gardens and dendrological parks in Ukraine, and his pedagogical studies is given. Range of scientists, whom he contacted and wrote letters to, especially such famous as Volodymyr Vernadskyi, Mykola Hryshko, Volodymyr Komarov, Oleksandr Fomin – is named.
THE USE OF DIDACTIC GAMES IN THE PROCESS OF THE PRESCHOOLERS’ CAREER GUIDANCE
Authors: LUKASHOVA Yu. , HNIZDILOVA O.
Published: April 2022

The article highlights the features of career guidance work with preschool children. It is established thatvarious tools and methods of work are used in the process of preschool children’s career guidance. It was found that didactic games contribute to the acquisition of the necessary knowledge of children about the professional activities of adults. The peculiarities of the use of didactic games in the educational process of preschool educational institution are revealed. The main types of didactic games that contribute to the enrichment of children’s knowledge about professions are games with objects, board-printed games, and verbal games. Samples are provided, and their main content is described. It is established that depending on the mastered material, didactic games perform different functions, such as acquaintance, consolidation, testing of children’s knowledge about professions. It is noted that introductory didactic games aim at acquainting children with different professions, tools, places, and the importance of their work. Consolidation games aim to generalize and systematize children’s knowledge about the representatives of certain professions. Diagnostic games aim at testing the preschoolers’ knowledge about the studied professions.Based on the analysis of the methodological support in a preschool educational institution on the problem of career guidance of preschool children, it was found that modern preschool education orients teachers to form children’s general knowledge about the most common professions, ignoring those that have emerged in recent years. The content of didactic games is offered, which is aimed at acquainting preschool children with the professions that emerge in modern society. Didactic games are divided depending on the type of human activity, and samples are developed for each type: man – holiday (“Animator”, “Aerodesigner”, “Event-manager”, “Operator”, “Florist”) man – computer (“Programmer”, “Web Designer”), a person – the sphere of services (“Courier”, “Confectioner”, “What’s in the bank?”, “Pizza maker”, “Barista”), a person – image (“Make-up artist”, “Eyebrow artist”, “Image maker”, “Stylist”, “Groomer”).Recommendations are given to teachers on the introduction of didactic games in the process of acquainting preschool children with professions. The main requirements for didactic games are highlighted: systematics, realism, duration, children’s interest, comprehensibility of tasks, humanism. It has been proved that didactic games are an effective means of career guidance work with preschoolers.
FORMATION OF MORAL AND SPIRITUAL VALUES IN THE SYSTEM OF MODERN EDUCATION ILLUSTRATED THROUGH PASTORAL MINISTRY
Authors: FAZAN V. , TERESHCHUK O.
Published: April 2022

The article analyzes and characterizes the direct relationship between socio-economic processes and the state of society. It is determined that personality level of morality and universal values begins with family upbringing and educational institutions. The problem of social behavior is very acute, society affords to falter between the constant desire to preserve its authenticity, traditions and the processes of globalization and at the same time relentless scientific and technological progress forces humanity to integrate into new social groups by adopting new cultural norms that can conflict with existing ones . Such confrontation leads to the inevitable social stratification and forces a person to develop only those qualities that will allow them to be competitive in the future, generates social cruelty and aggression, devalues human life and human values in general.According to sociologists, the quality of life in society is directly related to a set of values that serve as a social indicator of the level of society. The low level of moral and ethical norms leads to the devaluation of human life, the destruction of basic institutions of society, increased violence and human self-destruction The process of formation of moral and spiritual values in the individual is organically connected with education and plays an important role in the educational process of modern Ukrainian educational institutions. However, it should be noted that the effectiveness of such methods meets the modern requirements no longer and social needs in general, and students needs in particular. Therefore, on the way to find a solution to this problem, it is considered necessary to pay attention to the vast experience of forming Christian morality and ethics in society over the centuries of Christianity as an integral part of Ukrainian culture. Using the experience of forming moral and ethical norms in the process of personality development illustrated through pastoral ministry, it should be creatively applied in methods of personality education in the modern educational process.
ASPECTS OF FORMATION OF ECONOMIC COMPETENCE IN THE PROCESS OF TRAINING SPECIALISTS IN THE SOCIAL SPHERE
Authors: TERMOSA I.
Published: April 2022

The article describes the conceptual and categorical apparatus of the definition of “professional competence”. The main normative documents (professional standards and standards of higher education) and legislative acts to ensure the training of future specialists in the social sphere in the formation of their economic competence are identified. It is stipulated that the practical preparation of the future social specialist for social protection of various groups of the population, in particular social security, requires the formation of economic competence.The author’s vision of interpretation of economic competence of social specialists in terms of necessary knowledge, acquired skills, set of opportunities and abilities in the field of economic knowledge for effective professional activity in the field of social services, social assistance and social work in general. The constituent components of economic competence in the training of specialists in the social sphere are described: motivational, cognitive, procedural and personal.The cognitive component is highlighted as the most important, which reflects the rationale for the role of knowledge in the formation of economic competence. It is substantiated that the formation of economic competence of the future specialist in the social sphere takes place in higher education institutions within a holistic pedagogical process in the study of specialized socio-economic disciplines (“Economic foundations of social work”, “Economics of social work”, “Social economy”, “Social protection”). population “) and through the use of such methods of organizing educational activities as business games, situational tasks, development of socio-economic projects.It is established that the necessary role in the formation of economic competence in the training of a social worker is played by his knowledge of the determinants of social security as the main form of social protection - state social standards and guarantees. A brief description is given on the basis of legislative acts and the established size of the subsistence minimum as a state social standard and minimum wages and old-age pensions as the main state social guarantees.
SCIENTIFIC AND METHODOLOGICAL SUPPORT OF EDUCATION OF FUTURE TEACHER PERSONALITY IN THE HEALTHY ENVIRONMENT OF HIGH SCHOOL
Authors: MOMOT O.
Published: April 2022

The article substantiates the scientific and methodological support of educating the future teacher’s personality in terms of creating a health-preserving environment of high school: criteria with relevant indicators: motivational-value (formation of motivation and value orientations), cognitive (health-preserving knowledge, skills and abilities), procedural-activity (mastering of technologies, methods and means of health-preserving activity), practical (development of motor skills, self-esteem, activity, correction of own behavior), the levels of education of the future teacher in terms of creating a healthy environment of high school: high, sufficient, secondary, low.Structure of the model of education of the personality of the future teacher in the healthy environment of the high school, which consists of a target, substantive, procedural and control-effective block, each of which combines in its content structural components. The target block includes the social order, purpose, tasks, theoretical and methodological approaches, principles of education of the future teacher’s personality. The content block includes the content of educating the future teacher’s personality in the conditions of creating a healthy environment for higher education and educational and methodological support, which includes academic disciplines. The procedural block covers the stages of technology implementation, methods, forms, means of educating the personality of the future specialist. The control-performance block includes criteria, indicators and levels of education of the future teacher’s personality in the conditions of creating a healthy environment of high school as a result.Characterized the complex of organizational-pedagogical conditions of upbringing of a future teacher’s personality in a healthy environment of high school as a complex of structural components of a holistic educational system are interrelated: create healthy environment in higher education, the education of the healthy personality competence of future teacher of high school, developing innovative wellness climate in a team of teachers and future teachers of high school, introduction in educational process of high school training and methodological support and methods of its realization during the upbringing of a future teacher’s personality.
INTEGRATION ASPECTS OF PROFESSIONAL TRAINING AND FORMATION OF PROFESSIONAL COMPETENCE OF FUTURE MASTERS OF PHARMACY AT THE UNIVERSITY EDUCATION OF EUROPEAN UNION COUNTRIES AND UKRAINE
Authors: DOVDGUK V.
Published: April 2022

The scientific article on the basis of the theoretical analysis of European integration processes in the universities of the European Union identifies the integration aspects and their impact on the system of professional training of masters of pharmacy.It is determined that highquality professional training of future specialists in the pharmaceutical industry, the introduction of European experience in the context of European integration of free economic zones of Ukraine ensures their adaptation to implementation in the labor market, which is a necessary condition for successful professional activity.It has been established that the formation of the European University Association (EUA) and the initiated partnership of educational and scientific cooperation and exchange of experience in the effective organization of educational processes are influential for European integration processes.Experimental implementation of the developed scientific and methodological support a portfolio of scientific and methodological complexes in accordance with integrated curricula of professional disciplines of master’s training based on the model of integrated educational process of training future masters of pharmacy in universities of Central and Eastern Europe in the process of forming professional competence processes in medical and classical universities of Ukraine.Comprehensive diagnostics of the level of professional competence of students, readiness to implement professional competencies at the end of the formative experiment is based on test results, qualimetric questionnaires, as well as the results of assessing the quality of individual case tasks as an indicator of quality professional characteristics in experimental groups of students. distance learning.According to the results of the experimental study, the positive dynamics of students’ academic achievements in the Free Economic Zone was established and the effectiveness of the model of integrated educational process of training future masters of pharmacy in universities of Central and Eastern Europe and in Ukraine in European integration was confirmed.
THE HISTORIOGRAPHY OF THE PROBLEM OF LEGAL EDUCATION IN THE HIGHER MILITARY SCHOOL OF UKRAINE IN THE TWENTIETH CENTURY
Authors: CHERNYSH N. , ILCHENKO O.
Published: April 2022

The authors carried out a historiographical review of the development of legal education of officers in higher military education institutions of Ukraine in the twentieth century in terms of modern historical and pedagogical science.The article clarifies the concepts related to the organization of legal education of officers in higher military educationalinstitutions of the USSR and independent Ukraine. It was found that in the period under study laid the foundation for further development of the modern system of domestic military education.The authors analyzed a set of studies on the legal education of officers, the degree of scientific development of the problem of legal education in higher military school in Ukraine and identified areas for its study. The authors found that representatives of various fields of scientific knowledge (history, philosophy, law and pedagogy) studied certain aspects related to the legal education of officers in higher military educational institutions. Such as the systematization of the experience of officer training; pedagogy and psychology of higher military school; problems of development of the modern system of military education in Ukraine, humanitarianization and technological aspects of personalityoriented training of military specialists with higher education; content and structure of the process of legal training of the contingent in military educational institutions; legal regulation of the military education system.The article offers a classification of scientific works related to this issue according to: the moment of their creation (modern works and published in the period under study); origin (Soviet scientific works and published in independent Ukraine and the countries of the former USSR); purpose (those that reveal the peculiarities of maintaining general discipline in the army and are devoted to issues of team training); subject (legal education of officers as an element of professional training and in the context of rulemaking of public authorities and military administration.).It was found that despite the appeal of some scholars to certain aspects of the formation of legal education of military officers in Ukraine, this problem has not been the subject of a separate scientific study.