bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Agonist and PPAR Gamma Co-Activator 1α (PGC-1α) Activator
Ameliorates Cognitive Deficits, Oxidative Stress, and Inflammation in Rodent Model of Parkinson’s Disease
Authors: Das Nihar Ranjan , Vaidya Bhupesh , Khare Pragyanshu , Bishnoi Mahendra , Sharma Shyam Sunder
Published: December 2021

Background:

PPAR gamma co-activator 1α (PGC-1α) is known as the master regulator of mitochondrial biogenesis. It is also a co-activator of peroxisome proliferator-activated receptor-gamma (PPARγ) and plays a role in preventing mitochondrial dysfunction in several neurodegenerative disorders, including Parkinson’s disease (PD). Depletion in the levels of these proteins has been linked to oxidative stress, inflammation, and DNA damage, all of which are known to contribute to the pathogenesis of PD.

Objective:

In the present study, combination therapy of PPARγ agonist (GW1929) and PGC-1α activator (alpha-lipoic acid) was employed to ameliorate cognitive deficits, oxidative stress, and inflammation associated with the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD.

Results:

Our study showed that MPTP-induced PD rats exhibited an increase in oxidative stress and inflammation, leading to cognitive deficits. Furthermore, MPTP-induced PD rats also exhibited reduced mitochondrial biogenesis in comparison to control and sham animals. Intraperitoneal administration of GW 1929 and alpha-lipoic acid in doses lower than those earlier reported individually in literature led to an improvement in the cognitive deficits in comparison to MPTP-induced PD rats. These improvements were accompanied by a reduction in the levels of oxidative stress and inflammation. In addition, an increase in mitochondrial biogenesis was also observed after the combination of these pharmacological agents.

Conclusion:

Our results provide a rationale for the development of agents targeting PPARγ and PGC-1α as potent therapeutics for the treatment of neurological diseases like PD.
Predictors of COVID-19 Vaccine Acceptability among Patients Living
with HIV in Northern Nigeria: A Mixed Methods Study
Authors: Iliyasu Zubairu , Kwaku Aminatu A. , Umar Amina A. , Tsiga-Ahmed Fatimah , Nass Nafisa S. , Abdullahi Hadiza M. , Amole Taiwo G. , Salihu Hamisu M. , Aliyu Muktar H.
Published: December 2021

Background:

People living with HIV (PLHIV) are at increased risk of COVID-19 acquisition,
severe disease, and poor outcomes. Yet, little is known about COVID-19 vaccine hesitancy
among PLHIV in high HIV burden countries, such as Nigeria.

Objective:

This study aims to assess the acceptability of the COVID-19 vaccine and identify predictors
and reasons for vaccine hesitancy among patients living with HIV and attending a tertiary hospital
in Kano, northern Nigeria.

Methods:

Using a mixed-methods design, structured questionnaires were administered to a clinic-
based sample of patients living with HIV (n = 344), followed by 20 in-depth interviews with a
sub-sample. Logistic regression and the framework approach were used to analyze the data.

Results:

Less than half (46.2 %, n = 159) of the respondents were willing to take the COVID-19
vaccine. Vaccine acceptance was higher among non-Muslim PLHIV (Adjusted Odds Ratio (aOR)
= 1.26, 95 % Confidence Interval (95 % CI): 1.10-4.00), persons with high-risk perception (aOR =
2.43, 95 % CI:1.18-5.00), those who were not worried about infertility-related rumors (aOR =
13.54, 95 % CI:7.07-25.94) and persons who perceived antiretroviral drugs are protective against
COVID-19 (aOR = 2.76, 95 % CI: 1.48-5.14). In contrast, vaccine acceptance was lower among
persons who were not concerned about the potential effects of COVID-19-HIV co-infection (aOR
= 0.20, 95 % CI:0.10-0.39). The most common reasons for vaccine hesitancy included doubts
about the existence of COVID-19, low-risk perception, anxiety about antiretroviral treatmentvaccine
interactions, safety concerns, and infertility-related rumors.

Conclusion:

Covid-19 vaccine acceptance was low among PLHIV. COVID-19 vaccine acceptance
was associated with respondents’ faith, risk perception, perception of the protective effects of antiretroviral
treatment, concerns about COVID-19-HIV co-infection, and infertility-related rumors.
Vaccination counseling should be integrated into HIV treatment services to improve COVID-19
vaccine uptake among PLHIV in Kano, Nigeria and similar settings
The Need of E-ticket to Support the Public Bus Service Improvement Policy in a Developing Country
Authors: Sutandi Anastasia C.
Published: December 2021

Background:

Public buses are a major transportation mode in large cities in the developing country Indonesia. Nevertheless, most societies still use passenger cars. Therefore, the road authority has developed an important policy to improve public bus services soon. One of the public bus services is to change the bus operational system, including the manual ticketing system to an electronic ticket (e-ticket) system. In order to make the policy succeed, the road authority should ask for passengers’ opinions.

Objective:

The purposes of this study are to ensure that the bus e-ticket is needed to support the policy and then to determine important priority factors of bus e-ticket implementation.

Methods:

The data were collected using a direct survey with a questionnaire in large cities, Surabaya and Denpasar in Indonesia. A total of 565 bus passengers participated in this survey. An analysis was conducted through cross tabulation between the respondents’ demographic data and their perceived level of need and priority of implementation with regard to various factors of the e-ticket system. The Simple Additive Weighting method was used to determine the important priority factors.

Results:

Results indicated that a bus e-ticket needed for the cross tabulation average value is more than 3.60 out of 5.00 for all factors. Furthermore, the three highest values of factors based on the Simple Additive Weighting method are ease of access, availability of the bus routes information, and affordability of the e-ticket price.

Conclusion:

Since respondents indicate that the e-ticket is needed and is a priority, then the policy is beneficial not only to improve bus services in Indonesia but also in other developing countries with similar traffic and geometric conditions.
The Role of Transport in Reverse Distribution Chains
Authors: Shaharudin Mohd. R.
Published: December 2021

Reverse distribution operations have become significant to the manufacturers in supporting the firms to achieve the circularity of products in the reverse flow chains. There are four main components of the reverse distribution chains; inbound and outbound transportation, collection of returns, centralised returns centres, and recovery process. Transport is essential by reducing the lead time and transportation cost of the used and the recovered products. Therefore, it is pertinent that the manufacturers continue endeavouring for the sustainable transportation process in each of the components to ensure the success of the reverse distribution chains.
COL1A1 Gene Expression in Hepatitis B Virus (HBV) Related Hepatocellular Carcinoma (HCC) Egyptian's Patients
Authors: Mohamed Amal A. , Abo-Amer Yousry Esam-Eldin , Aalkhalegy Amyan , Fathalla Lamiaa Abdelfattah , Elmaghraby Mostafa Bedair , Elhoseeny Mohamed Mahmoud , Mostafa Sahar Mohamed , El-Abgeegy Mohamed , Khattab Rania Abdelmonem , El-damasy Dalia Ali , Salah Wafaa , Salem Abeer Mohammed , Elmashad Wael Mohamed , Elbahnasawy Mohamed , Abd-Elsalam Sherief
Published: December 2021

Introduction:

Collagens are the most abundant proteins in the human body, accounting for one-third of total proteins. Over the last few years, accumulated evidence have indicated that some collagens are differentially expressed in cancer. The aim of the study was to assess COL1A1 gene expression as a novel marker for the progression of hepatitis B cirrhosis into hepatocellular carcinoma.

Methods:

This cohort study included 348 subjects and was conducted between May 2018 and June 2019. Subjects were divided into 4 groups: group1 included HBV positive hepatocellular carcinoma patients “HCC” (n= 87), group II included HBV positive patients with liver cirrhosis “LC” (n = 87), group III included chronic hepatitis B patients with neither HCC nor cirrhosis “ C-HBV” (n = 87) and group IV consisted of healthy volunteers as controls (n = 87). Fasting venous blood samples (10 ml) were collected from each participant in this study and were used for assessment of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, albumin and alfa-fetoprotein (AFP). Another portion of blood was collected in 2 vacutainer tubes containing EDTA, one for Complete blood count and the other for gene expression of COL1A1.

Results:

The gene expression of collagen was 6.9 ± 8.8 in group 1 (HBV positive hepatocellular carcinoma patients) and this was a significant increase in comparison with the other groups. In group 2 (HBV positive patients with liver cirrhosis), the gene expression (collagen) was 3.7±1.5 and it was significantly increased when compared with group 4 (healthy volunteers).

Conclusion:

COL1A1 gene expression can be used as an indicator of the progression of hepatitis B cirrhosis into hepatocellular carcinoma.
Inhibition of Fenton Reaction of Glucose by Alcohols and Tetrahydrofuran
in Catalytic Concentrations: Calculation of the Stability
Constants of ROH/Fe2+ Complexes
Authors: Vitale Arturo Alberto , Bernatene Eduardo Alberto , Pomilio Alicia Beatriz
Published: December 2021

Background:

The Fenton reaction is of growing interest due to its primary function
in bodily processes and industrial waste disposal. However, the effects of alcohol on
this reaction have not been addressed. Therefore, we analyze for the first time the role that
catalytic concentrations of alcohols play in the Fenton reaction.

Methods:

The Fenton reaction was carried out by measuring oxidation-reduction potential
and pH monitoring under dark conditions to avoid photochemical reactions. The reaction
end point was established using the first derivative of plotting potential versus time. This
point was also checked by the dichromate test for hydrogen peroxide detection. Gas-liquid
chromatography was used to measure alcohol content. The Fenton reaction of glucose was
performed first, and then each alcohol, including ethanol, methanol, iso-propanol, and terbutanol,
was added separately in catalytic amounts, as well as the cyclic ether tetrahydrofuran.
The reaction rate constants and the stability constants of each complex formed were
measured.

Results:

Alcohols were shown to inhibit the Fenton reaction by forming iron-alcohol complexes.
An iron-tetrahydrofuran complex was also formed. The crucial oxygen role in the
functional group of alcohols and ethers is supported by a reaction with tetrahydrofuran.
These results also explain the difficulties in the disposal of sugar-enriched alcoholic industrial
effluents.

Conclusion:

Our findings show that alcohols, such as ethanol, methanol, iso-propanol, and
ter-butanol at catalytic concentrations, slow down the Fenton reaction due to decreased iron
availability by forming iron (II)-alcohol complexes. The method is also useful for calculating
stability constants for iron-alcohol and iron-tetrahydrofuran complexes, which are not
otherwise easy to assess.
Hubungan Pengetahuan Terhadap Sikap Pencegahan TRIAD KRR Pada Remaja Komunitas Penyanyi Jalanan (KPJ) Di Kabupaten Serang Tahun 2021
Authors:   Poltekkes Kemenkes Jakarta III, Budhi Ni Gusti Made Ayu Agung ,   Poltekkes Kemenkes Jakarta III, Sari Yulia ,   Poltekkes Kemenkes Jakarta III
Published: December 2021

Background of study: Adolescent is a group that very susceptible to 3 risks of basic adolescent reproductive health (TRIAD KRR) includes the aspect of sexuality, HIV/AIDS disease and misused of drugs. A free life, wild and without rules often be the main triggers for the lack of attitude of prevention related to TRIAD KRR. Research Purpose: This research is conducted to find out the relationship between knowledge towards the attitude of preventing three basic threats to adolescent reproductive health (TRIAD KRR) among youth street singer (KPJ) in 2021. Research Methods: This research is a quantitative analytic survey with a cross sectional research design. The sampling technique is using probability sampling with purposive sampling and using 33 teenagers from the youth street singer community in Serang Regency as the sample. For the statistical test, this research is using Chi-Square. Research results: Based from the statistic test, obtained the p value = 0,005 < 0,05 (alpha) with 10.267 OR value and 95% value of CI level of confidence between 2.002-52.649. It can be conclude that there is a relationship between knowledge and TRIAD KRR precautionary attitude on youth street singer in Serang Regency in 2021. Suggestion: This research can be used as an initial data or an illustration to be able to develop further research. For an optimized result, another research can be conducted with different designs with another variety of variables and expand the range of respondents number.
BULANIK MANTIK MODELLEMESİ İLE TAŞINMAZ DEĞERLEMEYE FARKLI BİR BAKIŞ
Authors: ESEN Yeşim , TOKGÖZ Hanifi
Published: December 2021

Bu çalışmada taşınmaz değerlemede bulanık mantık modellemesinin uygulanabilirliğinin ve hazırlanan veri setindeki değişkenlerin azaltılmasının yöntem üzerindeki etkilerinin araştırılması amaçlanmaktadır. Araştırma sahası olarak İzmir ili muhtelif ilçelerinde 120 tane bağımsız bölümün değerleme raporu kullanılmıştır. Değişkenler seçilirken, zaman ve ekonomik açıdan kazanım sağlanması, bürokratik işlemlerin en aza indirilmesi göz önünde bulundurulmuştur. Bu kapsamda değişkenlere nitelik azaltma işlemi uygulanmış olup, en az değişken ile istatistiksel olarak en başarılı veri setine ulaşılmıştır. Yapılan istatistiksel analizler taşınmaz değerlemede, bulanık mantık modellemesinin daha hızlı ve düşük hata payı ile tahminde bulunduğunu göstermektedir. Çalışmanın bulguları bir bütün olarak değerlendirildiğinde; nitelik azaltma işlemi kullanılarak, bulanık mantık modellemesinin taşınmaz değerlemede alternatif bir yöntem olarak kullanılabileceği düşünülmektedir.
VEKTÖR KONTROLLÜ SÜRÜCÜLER İÇİN ASENKRON MOTOR EŞDEĞER DEVRE PARAMETRELERİNİN ÜRETİCİ VERİ FÖYLERİNDEN KESTİRİLMESİ
Authors: GÜLBAHÇE Mehmet Onur , KARAASLAN Muhammed Emin
Published: December 2021

Son yıllarda meydana gelen endüstriyel gelişmeler gerek endüstriyel gerekse ev tipi uygulamalarda kullanılan asenkron motorların geniş bir hız aralığında kontrol edilebilmesini zorunlu kılmıştır. Vektör kontrolü algoritmaları sayesinde hız ve moment kontrolünün geniş aralıkta yüksek başarımlı bir şekilde yapılabilmesi için asenkron motorun eşdeğer devre parametrelerinin yüksek doğrulukla bilinmesi gerekir. Bu çalışmada sadece üreticilerin veri föylerinde paylaşmış olduğu kısıtlı bilgiler ile asenkron motorun eşdeğer devre parametrelerinin tahmini gerçekleştirilmiştir. Tahmin yöntemi asenkron motorun eşdeğer devresinden türetilen doğrusal olmayan denklemlerin Newton-Raphson yöntemi ile çözülmesi ilkesine dayanmaktadır. Önerilen denklem sistemi ve çözüm algoritması 20 farklı asenkron motor için test edilmiş ve deneysel olarak elde edilen eşdeğer devre parametreleri ile karşılaştırmalı olarak sunulmuştur. Dahası seçilen 4 farklı motor için deneysel olarak elde edilen hız-moment karakteristiği ve kestirilen parametreler ile hesaplanan hız-moment karakteristiği verilerek önerilen algoritmanın başarımı irdelenmiştir.
Automatic Recognition and Analysis of Balance Activity in Community-Dwelling Older Adults: Algorithm Validation
Authors: Hsu Yu-Cheng , Wang Hailiang , Zhao Yang , Chen Frank , Tsui Kwok-Leung
Published: December 2021

Background

Clinical mobility and balance assessments identify older adults who have a high risk of falls in clinics. In the past two decades, sensors have been a popular supplement to mobility and balance assessment to provide quantitative information and a cost-effective solution in the community environment. Nonetheless, the current sensor-based balance assessment relies on manual observation or motion-specific features to identify motions of research interest.

Objective

The objective of this study was to develop an automatic motion data analytics framework using signal data collected from an inertial sensor for balance activity analysis in community-dwelling older adults.

Methods

In total, 59 community-dwelling older adults (19 males and 40 females; mean age = 81.86 years, SD 6.95 years) were recruited in this study. Data were collected using a body-worn inertial measurement unit (including an accelerometer and a gyroscope) at the L4 vertebra of each individual. After data preprocessing and motion detection via a convolutional long short-term memory (LSTM) neural network, a one-class support vector machine (SVM), linear discriminant analysis (LDA), and k-nearest neighborhood (k-NN) were adopted to classify high-risk individuals.

Results

The framework developed in this study yielded mean accuracies of 87%, 86%, and 89% in detecting sit-to-stand, turning 360°, and stand-to-sit motions, respectively. The balance assessment classification showed accuracies of 90%, 92%, and 86% in classifying abnormal sit-to-stand, turning 360°, and stand-to-sit motions, respectively, using Tinetti Performance Oriented Mobility Assessment-Balance (POMA-B) criteria by the one-class SVM and k-NN.

Conclusions

The sensor-based approach presented in this study provided a time-effective manner with less human efforts to identify and preprocess the inertial signal and thus enabled an efficient balance assessment tool for medical professionals. In the long run, the approach may offer a ﬂexible solution to relieve the community’s burden of continuous health monitoring.
Insulin resistance in patients with psoriasis
Authors: Pankiv I.V.
Published: December 2021

Psoriasis is a chronic systemic inflammatory disease accompanied by an activation of skin dendritic cells with accumulation in the inflammatory foci of interleukin-23 and activated Th-1 lymphocytes (Th-17, Th-22). In recent years, there has been a large number of evidence linking psoriasis with other inflammatory diseases, including obesity, diabetes mellitus, atherosclerosis, hypertension, nonalcoholic fatty liver disease, polycystic ovary syndrome, benign prostatic hyperplasia, etc. All of these conditions are associated with systemic inflammation and insulin resistance induced by it. Psoriasis is the most common chronic dermatosis and affects 1–2% of the population in developed countries. Psoriasis as a chronic immune-mediated inflammatory skin disease is often associated with metabolic syndrome and its components such as obesity, hypertension, insulin resistance and dyslipidemia. The risk of developing metabolic syndrome in patients with psoriasis is 40% higher than in the general population. Psoriasis and metabolic syndrome share some pathogenic mechanisms such as chronic low-grade systemic inflammation and an increased level of pro-inflammatory cytokines. Systemic inflammation causes obesity, cardiovascular diseases, diabetes mellitus type 2. These conditions increase the risk of mortality among patients with psoriasis. There is a positive correlation between the severity of psoriasis and metabolic syndrome, which is manifested by a severe rash, reduction of the remission and higher risk of psoriatic arthritis development. The carriers of the risk allele of FTO gene are characterized by a more severe psoriasis, the presence of psoriatic arthritis and increased body mass index. A review of the literature focuses on the relationship between insulin resistance and the pathogenesis of psoriasis.
Prospects for the use of laser Doppler flowmetry to assess cutaneous blood microcirculation in diabetes mellitus
Authors: Shaienko Z.O. , Ligonenko O.V.
Published: December 2021

The аrticle considers the scientific and clinical aspects of laser Doppler flowmetry (LDF) in the diagnosis of the state of the microcirculatory bed in diabetes mellitus. LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocation tests, which provides a study of the state of regulatory mechanisms of microcirculation. The difficulties with studying the microcirculation are caused by the very small size of microvessels. The prevention and treatment of various microcirculatory disorders is one of the most important problems in medical practice. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes mellitus. The use of LDF in scientific researches will make it possible to reveal changes in microcirculatory bed functioning that are characteristic of diabetes mellitus. The possibility of non-invasive quantitative assessment of the state of microcirculatory blood flow in real time and the relative ease of use explains the high popularity of LDF in scientific researches and makes this method promising for use in clinical practice. This method can be of important diagnostic value for the study of the state of different levels of regulation of the microcirculatory tract and dynamic monitoring of the effectiveness of the prescribed treatment. Combined use of LDF to identify the risk of developing diabetic foot syndrome will allow to personify the treatment of diabetes. Among the most promising points of application should be noted the study of microcirculation in the early diagnosis of diabetes and its complications, clarifying the risk of complications, monitoring the effectiveness of treatment. The development of optimal evaluation methods of microcirculation is a prospect for further research.
The Culture of Philosophy Withering Away On the Basis of Hungarian Philosophical Experiences
Authors: Karikó Sándor
Published: December 2021

Philosophy is for itself, in other words, it is an activity for itself by itself. It is one of the most precious intellectual treasures and pleasures of a human being. There are many symptoms which show that abstract thinking has lost its former glory, its glorious position in society. Unfortunately, the culture of philosophy has become a degraded intellectual phenomenon, and this short study analyses the reasons for its diminished value. It would like to stress there reasons: the first is: the practicable principle and interest as the age symptom. The second is: when the politics intervenes in the philosophy of the function (but we know that act of the way of thought is other as the movement of politics. The third is: the responsibility or irresponsibility of the philosophers. This study remarks some critical point of views in connection of there reasons. In conclusion, I claim that the current state of philosophy is the business of everybody; philosophy is a common intellectual property for all of us. In contrast to the public awareness, it is not an “aristocratic genre” but a “plebeian” one.
De LaurentESE
Authors: Marinaccio Michael
Published: December 2021

An increasing amount of sociolinguistic research has been concentrated on diachronic idiolect change: the change of an individual’s dialect over time. This paper adds to this growing topic by analyzing the English idiolect change of Giada De Laurentiis, a heritage speaker of Italian. The study analyzes De Laurentiis’ LOT, START, and GOAT vowels, as well as the voice onset time (VOT) of voiceless stops [k] and [p] by measuring the utterances of the code-switched word ‘mascarpone’ across 20 seasons on television. The data reflect the influence of L2 US English (rhoticity, diphthongization, lengthened VOTs) on heritage Italian in De Laurentiis’ idiolect.
Regional Relocation and Phonetic Dialect Markers
Authors: Kuo Victoria
Published: December 2021

This paper tracks phonological change in the (ING) morpheme in two YouTube personalities over time. Both participants relocated to a different dialect region than their hometowns over the course of their careers, motivating the hypothesis of this paper: geographic relocation is a catalyst for adult accent change. With a longitudinal study method, I selected audio clips from different periods in each YouTuber’s life and collected formant measurements of the targeted words. Based on a Pearson’s correlation analysis and hypothesis testing models, the participants showed statistically significant progression in their speech over time. Additionally, the speakers exhibited audible shifts most likely as an effect of aging. It is inconclusive whether this study’s observations are influenced by the difference in dialect or societal pressures of the relocated locations without further research in the other variables of each regional dialect.
Formulation of Herbal Gel for Wound Healing from Hollarrhena Pubences, Withania Somnifera, Azadirachta Indica, Curcuma Longa
Authors: Ramdas Miss. Lavhale Harshada
Published: December 2021

Abstract: The present reaearch has been undertaken with the aim to fomulate and evaluate the herble gel containng alcoholic extract of Hollarrhena pubences(kurchi), Withania somnifera(ashwagandha), curcuma longa(turmeric)Azadiracht indica(neem). The gel formulation prepared by using various polymer bases(methyl cellulose) . The stability study have carried as perICH guideline. The result show that the gel formulation containing kurchi, ashwagandha, turmeric, neem has better stability than other. All formulation studied on animal model(rat).The present work justifies the use oh herbal gel containing ashwagandha, turmeric, neem, kurchi for wound healing. Keywords: wound healing; Hollarrhena pubences, withania somnifera, curcuma longa, azadirachta indica; topicle gel.
Reflection of the Concepts of Spirituality and Morality in the Uzbek Language in Social Life
Authors: Sharifboyevna Bobojonova Shohsanam
Published: December 2021

Annotation: This article describes in detail the role of the Uzbek language in human life today, its reflection in the concept of morality. The article discusses the importance of the category of spirituality in the Uzbek language, its role in human life and science. Keywords: Morality, spirituality, language, culture, development, progress, upbringing, character. Аннотация: В данной статье подробно описывается роль узбекского языка в современной жизни человека, его отражение в понятии морали. Отмечается важность категории духовности в узбекском языке, ее роль в жизни человека и науки. Kлючевыеслова: нравственность, духовность, язык, культура, развитие, прогресс, воспитание, характер.
The reengineering of built-up areas: structure and composition
Authors: Sborshchikov Sergej B. , Zhuravlev Pavel A.
Published: December 2021

Introduction. Engineering solutions of construction facilities are becoming obsolete due to the impact of scientific and technological progress, changes in consumer needs and production capabilities of the construction industry. A gap between consumer needs and characteristics of construction products is bridged by updating, modernizing, retrofitting and transforming design solutions. Materials and methods. The subject of the study is capital construction facilities that have various functional purposes: they structure built-up urban areas (space planning), whose urban planning solutions need reengineering in the course of operation. The article considers the list of capital construction entities that include industrial facilities (manufacturing, agricultural, and communication facilities), non-industrial facilities (public buildings, residential housing) and linear objects (overpasses, pipelines, power grids). Functional, planning, structural, organizational and technological features of capital construction facilities, features of vital processes, production and technological procedures, that are underway inside them, determine the characteristic differences in the composition and structure of construction reengineering. Structural and functional analysis is the research method of the study. Results. The composition of actions and methods used to reengineer residential and industrial buildings, areas occupied by the engineering and transport infrastructure is described. The article presents changes introduced by reengineering actions with regard for the features of facilities that structure urban development. The co-authors acknowledge that the structure and composition of construction reengineering are highly variable, and their variability is determined by the types of built-up areas and their transformation methods. This dependence impacts a combination of reengineering actions, including those that determine the nature of transformation and supplement the principal change. The research results allow to develop reengineering process organization charts and outline the resource provision process.
ROLE OF THE FUEL AND ENERGY COMPLEX IN THE DEVELOPMENT OF HOUSING AND UTILITIES IN THE AMUR REGION
Authors:   Alexander Nikolaevich Kozlov Amur State University, KOZLOV ALEXANDER NIKOLAEVICH , MIROSHNICHENKO TATIANA ALEXANDROVNA ,   TATIANA ALEXANDROVNA MIROSHNICHENKO Amur State University, KOZLOV VITALY ALEXANDROVICH ,   VITALY ALEXANDROVICH KOZLOV Far Eastern Distribution Grid Company JSC, ROTACHEVA ALLA GEORGIEVNA ,   ALLA GEORGIEVNA ROTACHEVA Amur State University
Published: December 2021

When analyzing the role of the fuel and energy complex in the development of the housing and communal sector of the Amur Region, the emphasis was placed on the provision of the population with electricity. It was revealed that the consumption of electricity by the population is growing, despite the decrease in the number of Amur residents. The leaders in per capita electricity consumption are urban districts, as well as northern and a number of southern municipal districts.
SOLAR ENERGY - DEVELOPMENT PROSPECTS
Authors:   EKATERINA YURIEVNA ARTYUSHEVSKAYA Amur State University, ARTYUSHEVSKAYA EKATERINA YURIEVNA , MYASOEDOV YURI VIKTOROVICH ,   YURI VIKTOROVICH MYASOEDOV Amur State University, MYASOEDOVA LARISA ANATOLIEVNA ,   LARISA ANATOLIEVNA MYASOEDOVA  Amur State University
Published: December 2021

The article substantiates the need for the development of renewable energy sources, the most promising direction is solar energy. Its main advantages are determined in comparison with traditional methods of energy generation, as well as with other renewable energy sources. The prospects for the development of solar energy in the Russian Federation are considered.
Phytochemical analysis of different extracts of Pinda concanensis and Heracelum grande
Authors: Bidve Sucheta , Auti Sanjay
Published: December 2021

Aromatic plants are a reservoir of secondary metabolites that are responsible for the plants' medicinal efficacy and a major source of aromatic compounds and essential oils.  Now a day, there is a renewed interest in the plant kingdom in the search for novel bioactive and fragrance compounds as demands for herbal products are increasing enormously. In the present study two endemic plants, Pinda concanensis and Heracelum grande from Western Ghats were analyzed for secondary metabolites by using different plant parts (roots, leaves, and seeds) and by using range of solvent from polar to non-polar.  Glycosides, terpenoids, tannins, flavonoids, saponins, steroids, and alkaloids were found in methanolic extracts of Pinda concanensis root, leaf, and seeds and methanolic extracts of seeds of Heracelum grande. While extracts of chloroform and petroleum ether exhibits presence of some of them. Obtained results show the importance of both the plants as an important source of biologically active molecules for pharmaceuticals and cosmetic industries.

Keywords: Phytochemical screening, secondary metabolites, biologically active compounds.
Assistance of Gut Microbiota in Depression
Authors: Reji Reeja T , Ravi Krishna , Sambath Kumar R.
Published: December 2021

The association between gut microbiota and mental health is a relatively new research topic that has gained traction in recent years. Depression is a serious mental illness and a leading cause of disability, morbidity, and mortality worldwide. Based on the WHO reports, there are approximately 350 million people affected by depression globally. Currently available treatments can temporarily alleviate the symptoms of depressive illness, but these management plans are unable to completely reverse the multifactorial pathology of depression, and the antidepressant medications may produce side effects and adverse drug reactions which may turn down the quality of life of patients. Research has shown that the gut microflora interacts with the brain through various mechanisms, and this leads to the recognition of the microbiome in managing mental health. By unveiling the complexities involved in this area can help to develop novel strategies to treat the depressed patients and to prevent the public from falling to depressive disorder.

Keywords: Gut microbiome, depression, neurotransmitters
The effect of Cisplatin on Complete blood count among chemotherapy Sudanese patients at Taiba Cancers Center in Khartoum state 2021
Authors: Yousif Alaa Ahmed Mohamed , Merghani Maye M. , Babiker Nihad Elsadig
Published: December 2021

Background: Cisplatin is one of therapy used as anticancer activity in a variety of tumors. Among many chemotherapy drugs that are widely used for cancer, Cisplatin is one of the most compelling ones. Material and methods: This study was Analytical cross sectional study conducted at Taiba Cancer Center, Khartoum, Sudan, during the period July 2021 to November 2021 and aimed to estimate the complete blood count among chemotherapy Sudanese patients treated with Cisplatin. 50 cancer patients treated with cisplatin as chemotherapy selected as a case group and 50 apparently health donor were selected as control group. Three ml of the venous blood was collected in EDTA container. Six sample collected from each patient before each dose of cisplatin. Complete blood count was done by using Sysmex Automated Hematology Analyzer KX 21N.Result: When compared the base line of case value of RBCs, Hb, WBCs, neutrophils, and platelets with control there were insignificant differences (P. value ≥ 0.05). But when compared RBCs, Hb, WBCs, neutrophils, and platelets between the case (baseline) and the cases in cycle 1, 2,3,4 and 5 there was significant decreased among progression of doses (P. value ≤ 0.05). There was insignificant correlation in the duration of the cancer and WBCs, neutrophil count, HGB and platelets count (P. value ≥ 0.05), significant correlation with RBCs in baseline and cycle 2 (P. value < 0.05). When correlate the anatomical location of cancer with WBCs, neutrophil count there was insignificant correlation, and significant correlation with RBC and HGB in cycle 5 and platelets count cycle 2 and cycle 3 Conclusion: The study observed that Cisplatin with combination of drug can effect on the hematological parameters also the chemotherapy was induced anemia, neutropenia and thrombocytopenia.
Effect of Time and Haemolysis on Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) Measurement on Blood Samples
Authors: Eshag Tahia Jafar Abdo Alhakam , Merghani Maye M. , Babiker Nihad Elsadig
Published: December 2021

Background: Coagulation, also known as blood clotting, is the process by which blood convert from a liquid to a gel, forming a blood clot. It referred to haemostasis, the stopping of blood loss from a damaged vessel, followed by repair.

Material and methods: This was cross sectional study conducted at the albawasla medical laboratory, Khartoum, Sudan during the period August to November, 2021 and to evaluate the effect of time and hemolysis on prothrombin time and activated partial thromboplastin time tests. 50 samples (case group) were collected from the patients attending police teaching hospital   and requested to the PT and APTT test in addition to that,50 apparently healthy donors with no history of any coagulation problems or any chronic disease were selected as control group. Three ml of venous blood samples were collected in container with Tri Sodium Citrate anticoagulant. The coagulation tests (PT and APTT) were performed using semiautomatic device (coagulometer machine MI).

Results:  The result of this study revealed that; when compared the measurement of PT and APTT immediately and after one hour there was insignificant differences (p. v.>0.05).  also when compared the measurement of PT and APTT between hemolyzed and non-hemolyzed samples there was significant differences ( p. v.<0.05)  in addition when compared case and control for the PT and APTT immediately,  after one hour, hemolyzed and non-hemolyzed sample there was significant differences ( p. v.<0.05) except the APTT hemolyzed samples  and  insignificant differences with age and gender ( p. v.>0.05).  For the correlation there was significant correlation in the case group for the PT and APTT immediately, after one hour, and hemolyzed samples.

Conclusion: In the cases group results showed insignificant differences in the results of PT and APTT between immediate sample and after 1 hour in and significant differences in the results of PT and APTT between hemolyzed and non-hemolyzed samples, also there was insignificant differences between age and gender, immediately, after one hr. and hemolyzed sample in PT and APTT.

Keywords:  Homeostasis,  hemolyzed  sample, PT and APTT
Research on the Progress and Future Development of Technological Innovation of Intelligent Agricultural Machinery in China
Authors: Xianfa F. , Haihua W.
Published: December 2021

Agricultural machinery is the key fi eld in modern scientifi c and technological innovation. In recent years, China has made great achievements in the development of high-performance intelligent agricultural machinery with cutting-edge technology, which promotes the effi cient use of agricultural resources and environment-friendly development, and supports 70 percent of China’s agricultural mechanization production. This paper mainly focus on the innovation and progress in the fi eld of intelligent agricultural equipment technology in China from the aspects of information perception and precision production monitoring technology, intelligent operation management technologies, power machinery, farmland operation machinery, intelligent harvesting technology, production technology and agricultural products processing equipment. the paper also summarizes that, in the future, green, intelligence and universality will become the main characteristics of the development of intelligent agricultural machinery technology, and cross integration, extension and expansion will become the main direction of technological innovation. At last by referring to the application basis and cutting-edge technology of China’s intelligent agricultural machinery industry, the innovation and development goals and research direction of future intelligent agricultural equipment, the scientifi c and technological innovation and industrial development trend in the fi eld of agricultural mechanization and intelligent application integration, this paper puts forward some suggestions on the research direction of future intelligent agricultural equipment.
Improved upper bounds on the stabilizer rank of magic states
Authors: Qassim Hammam , Pashayan Hakop , Gosset David
Published: December 2021

In this work we improve the runtime of recent classical algorithms for strong simulation of quantum circuits composed of Clifford and T gates. The improvement is obtained by establishing a new upper bound on the stabilizer rank ofmcopies of the magic state|T⟩=2−1(|0⟩+eiπ/4|1⟩)in the limit of largem. In particular, we show that|T⟩⊗mcan be exactly expressed as a superposition of at mostO(2αm)stabilizer states, whereα≤0.3963, improving on the best previously known boundα≤0.463. This furnishes, via known techniques, a classical algorithm which approximates output probabilities of ann-qubit Clifford + T circuitUwithmuses of the T gate to within a given inverse polynomial relative error using a runtimepoly(n,m)2αm. We also provide improved upper bounds on the stabilizer rank of symmetric product states|ψ⟩⊗mmore generally; as a consequence we obtain a strong simulation algorithm for circuits consisting of Clifford gates andminstances of any (fixed) single-qubitZ-rotation gate with runtimepoly(n,m)2m/2. We suggest a method to further improve the upper bounds by constructing linear codes with certain properties.
Messengers in the Creative Work of Journalists
Authors: Kim M. N.
Published: December 2021

In the article the author dwells on the problems of the influence of messengers on the nature of internal communication in the editorial team. There introduce the interviews with the journalists of urban and regional media about the use of messengers in the organization of the editorial work; about new technical possibilities of this type of contact; about use of messengers in the creative work of journalists and more. Also, in the article touches upon the main methods of use messengers in solving editorial tasks: in coordination the actions of journalists; in organizing various group chats; in establishing effective working communications.
The Application of Big Data in Modern National Economy and Politics
Authors: Tian Weili
Published: December 2021

Big data is a new stage of informatization development. With the convergence and integration of information technology and human production and life, the rapid spread of the Internet, global data showing explosive growth and massive agglomeration, have had a significant impact on economic development, social governance, national management, and people’s lives.

Countries around the world regard the promotion of economic digitization as an important driving force for innovation and development, and have made forward-looking layouts in cuttingedge technology research and development, data open sharing, privacy and security protection, and talent training.

In-depth understanding of the current situation and trends of big data development, and its impact on economic and social development, analyze the achievements and existing problems of my country’s big data development, summarize and discuss the government’s response strategies, and promote the innovation of government management and social governance models, and realize government decision-making Identification, precise social governance, and efficient public services all have important meanings.
Method for determining uncertainty and error in the process of ophthalmic lens calibration
Authors: Salgar-Marín Alejandro , Vargas Javier Alberto , Ramírez-Barrera Andrés Felipe
Published: December 2021

In the present investigation, a scientific procedure was developed, and a mathematical model was proposed, with the objective of determining, under standard conditions, the uncertainty, and the measurement of dioptric power in ophthalmic lenses. The methodology of the scientific procedure is based on the fundamentals of geometric optics, this process guarantees and establishes a standardized uncertainty measure in repeatable and reproducible processes. The methodology is complemented with a proposed mathematical model based on the guide for the expression of uncertainty in measurement - GUM. This model can be applied to lenses used for calibrating eye care equipment (such as lensometers, which are used to diagnose myopia and farsightedness) by evaluating the lenses without having direct contact with patients. When the proposed mathematical model was applied, its experimental result was a maximum expanded uncertainty of ± 0.0079 diopters in a 0.5-diopter lens. This is optimal compared to the result of other authors this article, who reported a maximum expanded uncertainty of ± 0.0086 diopters. In conclusion, the application of this scientific procedure provides manufacturers and users of this type of lenses with a reliable measurement thanks to a calibration process based on geometrical optics and centered on patient safety.
Análisis de la precipitación y la evaporación en el Orinoco colombiano según los modelos climáticos regionales del experimento CORDEX-CORE
Authors: Florian-Vergara Carolina , Salas Hernán D. , Builes-Jaramillo Alejandro
Published: December 2021

Con el fin de representar la precipitación y evaporación total mensual en una cuenca hidrográfica del Orinoco colombiano, este trabajo evaluó la capacidad de los modelos climáticos regionales incluidos en el Experimento regional coordinado de reducción de escala (CORDEX-CORE). Para ello, complementariamente, se incluyeron datos de precipitación y evaporación total de fuentes como Climate Hazards Center InfraRed Precipitation with Station data (CHIRPS), el reanálisis atmosférico (ERA5), Global Precipitation Climatology Center (GPCC) y Global Land Evaporation Amsterdam Model (GLEAM). Las comparaciones entre los ensambles de los modelos y las observaciones se hicieron utilizando métodos gráficos y métodos cuantitativos, entre ellos: diagramas de cajas, porcentajes de sesgo, eficiencia de Nash-Sutcliffe, entre otros. Los resultados evidencian que los valores promedio de precipitación están adecuadamente representados, en términos de su temporalidad y magnitud, por el ensamble del modelo RegCM, mientras que los valores promedio de evaporación total están mejor representados por el ensamble del modelo REMO en términos de la temporalidad, más no en su magnitud. Por otra parte, las estimaciones de caudal de largo plazo evidencian que los valores de evaporación total proporcionados por los modelos permiten una adecuada estimación del caudal promedio de largo plazo, pero no la adecuada estimación del ciclo anual de caudales. Este trabajo es pionero en la evaluación de los datos de precipitación y evaporación total mensual suministrados por CORDEX-CORE en el Orinoco colombiano, sienta precedentes para la incorporación de datos de modelos regionales para fines hidrológicos en zonas poco instrumentadas del país, y es el primer paso hacia la evaluación de escenarios regionalizados de cambio climático.