bluuebunny/crossref_metadata_2025 huggingface dataset:
Metformin From Diabetes Management to Broader Applications in Weight Reduction and Metabolic Health
Authors: Zapasek Daniel , Słowik Julia , Bajak Mateusz , Szczepański Michał , Mamczur Maciej , Kuliga Marcin , Inglot Julia , Inglot Jadwiga , Feret Dominik Maciej , Sowa Damian
Published: December 2024

Introduction
Metformin is a widely used oral hypoglycemic agent for type 2 diabetes, with origins in medieval European medicine through the use of Galega officinalis. Subsequent centuries of research led to the development of synthetic biguanides, with metformin's approval as an antidiabetic agent in 1957. Since then, its therapeutic applications have broadened to address other metabolic and endocrine disorders, such as obesity, polycystic ovary syndrome (PCOS), and antipsychotic-induced weight gain.
Purpose of the Study
This study aims to review metformin's pharmacological properties, mechanisms of action, and its expanded clinical applications. Specifically, it focuses on metformin’s role in promoting weight loss and improving metabolic health across diverse patient populations, including those without diabetes. The study also addresses evidence gaps and proposes areas for further research on dose optimization and safety in non-diabetic populations.
Materials and Methods
A systematic literature review was conducted using databases such as PubMed and Google Scholar, focusing on studies examining metformin's effects on glycemic control, weight reduction, and metabolic stability.
Conclusions
Metformin's history underscores its evolution from traditional remedies to a versatile pharmacological agent for treating diabetes and other metabolic conditions. Ongoing research is essential to fully establish its optimal therapeutic parameters and long-term safety for diverse patient groups.
Optimization of Feature Selection on Semi Supervised Data
Authors: Wijayanti Dian Eka , Surono Sugiyarto , AD Deshinta , Afriyani Sintia
Published: December 2024

This research explores feature selection optimization in semi-supervised text data by utilizing the technique of dividing data into training and testing sets and implementing pseudo labeling. Proportions of data division variations, namely 70:30, 80:20, and 90:10, were used as experiments, employing TF-IDF weighting and PSO feature selection. Pseudo labeling was applied by assigning positive, negative, and neutral labels to the training data to enrich information in the classification model during the testing phase. The research results indicate that the Linear SVM model achieved the highest accuracy at a 90:10 data division proportion with a value of 0.9051, followed by Random Forest with an accuracy of 0.9254. Although RBF SVM and Poly SVM yielded good results, KNN showed lower performance. These findings emphasize the importance of feature selection strategies and the use of pseudo labeling to enhance the performance of classification models in semi-supervised text data, offering potential applications across various domains that rely on semi-supervised text analysis.
HOTS-oriented mathematical problemsolving ability judging from student learning styles
Authors: sheilawati Kharisa rinandyta , setyaningsih Rini , Rejeki Sri
Published: December 2024

This research aims to analyze students' mathematical problem solving abilities in solving Higher Order Thinking Skills (HOTS) oriented mathematics problems in Algebra material. Students have the opportunity to find out to what extent their abilities are in solving problems. This research can provide experience in solving mathematics problems that can measure high-level thinking abilities. This research uses a qualitative descriptive method. The subjects of this research consisted of 6 students of class VIII Science 4 at MTs Negeri 1 Surakarta. Data collection techniques consist of questionnaires, tests and interviews. Data analysis techniques consist of data presentation, data reduction, and conclusions. The results of this research are the mathematical problem solving abilities of class VIII Science 4 students based on the visual learning style type which is the same as the auditory learning style in solving problems on SPLDV material, namely being able to carry out up to the fourth stage of Polya (understanding problems, making problem solving plans, solving problems, and examining returning the process and results of problem solving). Meanwhile, the mathematical problem solving abilities of class VIII Science 4 students are based on the kinesthetic learning style type, namely implementing up to the third stage of Polya (understanding the problem, making a problem solving plan, and solving the problem).
The Tahani Fuzzy Logic Method for Detecting Violence against Women in North Sumatera
Authors: NISA KHAIRUN , Sari Rina Filia
Published: December 2024

Violence against women is a pervasive issue in society. Violence often encompasses various forms, such as physical, psychological, economic, and sexual violence. This research employs the Tahini fuzzy logic method to predict cases of violence against women. The results of the analysis in query fuzzification indicate that there are 16 districts experiencing high values in cases of violence against women, namely: Asahan, Batu Bara, Dairi, Deli Serdang, Karo, Binjai City, Gunung Sitoli City, Pematang Siantar City, Tanjung Balai City, Labuhan Batu Utara, Labuhan Batu, Langkat, Padang Lawas Utara, and Simalungun. This research also provides recommendations based on detection results, utilizing the fire strength value as the highest level ranking. Looking at the total 33 districts in North Sumatera, the highest level of violence against women is in Medan City, which occurred from July to December 2022, where all four criteria for typical cases of violence against women are significantly high.
Framing Gibran Rakabuming Raka: A Media Analysis of CNN Indonesia's Coverage of His Vice-Presidential Nomination
Authors: Qirom Rizqi Latiful , Wibowo Arif Ardy , Nasir Roziani
Published: December 2024

Indonesia will celebrate democracy in 2024. In order to nominate candidates for president and vice president of Indonesia between 2024 and 2029, a coalition of several political parties will be formed. Prabowo Subianto and his running mate, Gibran Rakabuming Raka, are among the presidential candidate pairings being promoted. However, because of his youth and PDI Perjuangan party connection, Gibrans's nomination as a vice presidential candidate generated a range of public reactions. The PDI Perjuangan has formally announced Ganjar Pranowo and Mahfud MD as their candidates for the next Indonesian presidential election. Other media channels, such as CNN Indonesia, have taken notice of Gibran's situation and have included large headlines and in-depth coverage on their websites. Gibran's coverage aims to clarify his role as Prabowo Subianto's running mate for vice president and as a member of the PDI Perjuangan party. The purpose of this study is to examine how Gibran's reputation was built within CNN Indonesia following his unsuccessful bid for vice president. The study used a case study approach and a descriptive qualitative methodology. The Zhongdang Pan and Gerald M. Kosicki framing analysis model, which identifies media with syntactic, script, thematic, and rhetorical structures, was used to analyze the CNN Indonesia media. According to the statistics, CNN Indonesia developed Gibran's viewpoint by taking into account a variety of viewpoints from other people. None of the four news stories that were examined contained a resignation letter explaining Gibran's reason for leaving the PDI Perjuangan cadre.
Inclusive Disability Empowerment: Utilization of Digital Applications in Accessing Information for People With Disabilities
Authors: Pudrianisa Sheila Lestari Giza , Astari Devi Wening , Agustina Dwi Pela
Published: December 2024

Digital inclusion is one of the initiatives by the Telecommunication and Information Accessibility Agency under the Ministry of Communication and Informatics. It aims to ensure that all individuals can easily access digital technology and the internet. However, digital inclusion has not been fully realized, particularly in terms of providing digital information access for people with disabilities. The purpose of this Digital Accessibility Study for Empowering Disability Inclusion is to examine the significance of digital information accessibility as a crucial factor in enhancing the inclusion and empowerment of individuals with disabilities. This study emphasizes the use of digital technology to improve information accessibility, thereby fostering independence among people with disabilities. It also aims to identify the obstacles and challenges these individuals face in achieving equal access to digital information. Utilizing qualitative descriptive methods, data for the study was collected through observations and Focus Group Discussions (FGDs) with the disability community, as well as through documentation. The findings indicate that the accessibility of information through digital applications has begun to show positive effects, particularly for individuals who are deaf or blind. Applications such as TalkBack, VoiceOver, Cash Reader, Be My Eyes, Voluntary, Infusion, Special Help, WhatsApp, Facebook, Instagram, and others, along with specialized hardware, contribute to the independence of people with disabilities. However, while information can be accessed, it remains insufficiently friendly to all disabilities. Both deaf and blind participants expressed that governmental support needs more emphasis, and they highlighted the necessity for enhanced social support from family, friends, and the community to help bridge the gap for individuals with disabilities.
Comparison of Yam Composite Cookies Sensory Characteristic Between Sugar and Stevia Sweeteners
Authors: Makiyah Sri Nabawiyati Nurul , Setyawati Ika , Rahmadhia Safinta Nurindra , Tasminatun Sri , Kita Masaki
Published: December 2024

Yam (Dioscorea alata L.) is one source of carbohydrates with a low glycemic index. It is useful for controlling blood glucose levels. Yam has high carbohydrate and protein content but low sugar content. This research contributed to compare the sensory characteristics of the yam composite cookies between sugar and stevia sweeteners. This research is a quasi-experimental study with a cross-sectional design. Purple yam tubers were made into yam flour. The composite was made from yam flour and green bean flour (F1=100:0; F2= 80:20; F3= 60:40; F4= 40:60; F5= 20:80) (%w/w). Composites were processed into cookies with sugar and stevia sweeteners. Cookies with sugar and stevia sweeteners tested sensory characteristics to 31 in healthy adults aged 25-35. The results showed that the sensory characteristics of shape, size, color, texture, sweet taste and umami taste of yam cookies with sugar sweetener were not better than stevia sweetener. In contrast, the sub-variables of aroma, taste, and overall sweet potato cake with sugar were better than stevia. This implies that yam composite cookies with stevia sweeteners are healthier, but less desirable.
Halal Perspective Review of Cultured Meat Stem Cell Method
Authors: Qudsiyah Ussy Siti , Tsania Amany Awfa
Published: December 2024

Cultured meat is meat made in vitro based on cells or biotechnology meat that can replace animal meat products in general. The halal status of cultured meat is still a matter of debate in society. The aim of writing this systematic literature review is to discuss the halal status of cultured meat. The method used in writing this systematic literature review is based on the results of a systematic literature review; several researchers used Google Scholar, ScienceDirect, and other applications such as Microsoft Excel. SLR is an effort to make the often subjective literature review more objective to reduce researcher bias. This paper uses a systematic literature review to review published studies on halal perspectives of cultured meat. The relevant material was accessed and sourced from Google Scholar databases with a publication period from 2022-2024 and provide open access journals. Research results show that animal cells taken from animals that have been slaughtered according to Islamic law and rules are said to be halal for consumption. However, if the production of cultured meat comes from non-halal animals or from halal animals but the slaughter is not in accordance with Islamic law and rules, then it is haram for consumption.
Physical, Chemical, and Biological Pretreatment of Lignocellulose in Oil Palm Empty Fruit Bunches (OPEFB)
Authors: Devi Devi , Ratnasari Ika Fitriana Dyah , Astutik Dwi , Widodo Hery , Ismoyojati Roni , Sajjad Nimra
Published: December 2024

Oil Palm Empty Fruit Bunch (OPEFB) constitutes a solid waste generated by the palm oil industry. Empty palm oil bunches contain cellulose or fiber. This component is the primary source for generating valuable products, including fermented sugar, chemicals, liquid fuel, carbon sources, and energy. This research contributed to determine the lignin, hemicellulose, and cellulose content of empty palm oil fruit bunches during biological, physical and chemical Pretreatment, as well as to determine the degradation of lignin, hemicellulose and cellulose. Physical treatment uses steam explosion, chemical treatment uses NaOH and biological treatment uses Trichoderma reesei FNCC 6012. Pretreatment using steam explosion has temperature levels ranging from 120 ℃, 140 ℃, and 160 ℃. Treatments using NaOH consisted of concentrations of 2%, 4%, and 6%, while treatments using Trichoderma reesei were based on fermentation times of 5 days, 10 days, 15 days. This preliminary treatment functions to reduce the lignin levels in empty palm oil fruit bunches. The parameters observed in this research were lignin, hemicellulose and cellulose content. The research results showed that treatment using Steam explosion at temperatures of 140 ℃ and 160℃ was able to reduce lignin levels by 16.03% and 15.90%. Treatment using steam explosion at a temperature of 160 ℃ and Trichoderma reesei for 15 days was able to increase Hemicellulose levels by 35.84% and 36.21%. Treatment using Steam explosion at a temperature of 160℃ gave the best effect on cellulose of 51.09%.
Adolescents Cyberbullying: Examining The Role of Social Media Use Intensity and Dark Triad Personality
Authors: Adinata Surya Prawira , Kesumaningsari Ni Putu Adelia , Setiasih Setiasih
Published: December 2024

Cyberbullying is a form of harassment carried out through electronic devices, often involving social media platforms. This study aimed to determine the role of social media use and dark triad personality in predicting adolescents’ involvement in cyberbullying. The study involved 219 adolescents aged 12-21 who had engaged in cyberbullying within the past six months. Data were collected using three scales: the Social Media Use Integration Scale, Short Dark Triad, and Cyber-Aggression Scale. The results indicated that both intensity of social media use and dark triad personality traits simultaneously predicted cyberbullying behavior among adolescents, with psychopathy emerging as the most significant contributor to the observed behaviors. The study suggests that while social media use alone may not directly lead to cyberbullying, it serves as a facilitating platform for individuals with psychopathic tendencies. The study’s findings highlight the importance of parents, counselors, and the community working together to prevent cyberbullying behaviors among adolescents.
Screen Time on Multiplayer Online Battle Arena (MOBA) as Mediator Between Trash-Talking and Aggressive Behavior of Esports Players
Authors: Baudin Jomar Saif Peñamante
Published: December 2024

While extensive research has examined the relationship between gaming and aggression, few studies have focused on the factors that mediate the connection between trash-talking behavior and aggressive outcomes in multiplayer online battle arena (MOBA) games. This study addresses this gap by investigating the role of screen time as a mediator between trash-talking and aggressive behaviors in young players of Mobile Legends: Bang Bang (MLBB). Unlike previous research that primarily explored direct links between gaming and aggression, this study introduces screen time as a novel variable that influences this relationship. The study sampled 390 gamers aged 10 to 24 years, all enrolled at Southern Luzon State University in Lucban, Quezon, Philippines. Key variables, including verbal aggression, hostility, and anger, were assessed using standardized questionnaires, along with measures of trash-talking attitudes and screen time. Using mediation analysis, the study identified screen time as a key factor that explains the relationship between trash-talking and aggression. The findings revealed that trash-talking indirectly contributes to aggressive behavior through prolonged gaming exposure. In other words, the negative effects of trash-talking on aggression are amplified by increased screen time. This discovery offers a fresh perspective by highlighting screen time as a critical channel through which trash-talking influences aggression. The results underscore the importance of addressing both toxic communication and excessive screen time to foster a healthier and more sustainable gaming environment. As mobile gaming continues to dominate youth leisure activities, these findings provide actionable insights for developing interventions that reduce aggression and encourage positive competition in esports
Does Self-Regulated Learning Mediate the Effect of Smartphone Addiction on Academic Procrastination? A SEM Analysis
Authors: Yulita Tarigan Devi Eka , Darmayanti Nefi , Surbakti Amanah
Published: December 2024

Delays in completing final assignments are common among final-year students. This research aims to examine the influence of smartphone addiction on academic procrastination through the mediator of self-regulated learning. The study uses a quantitative approach, with data collection methods involving academic procrastination scales, smartphone addiction, and self-regulated learning. The respondents in this study consisted of 304 students, selected using purposive sampling. The data were analyzed using Structural Equation Modeling (SEM) with Amos version 26. The research findings indicate that (1) there is a positive effect of smartphone addiction on academic procrastination, (2) there is a negative effect of smartphone addiction on self-regulated learning, (3) there is a negative effect of self-regulated learning on academic procrastination through the mediator of self-regulated learning, and (4) smartphone addiction influences academic procrastination through the mediator of self-regulated learning.
Psychoeducation Using Symbol Modeling Techniques for Enhancing the Subjective Well-Being of Long-Distance Marriage Couples
Authors: Kurniady Dedy , Firman Firman
Published: December 2024

Long-distance married couples tend to experience anxiety, stress, unhappiness, delayed problem resolution, difficulty finding time together, and feelings of helplessness without their partner. However, previous psycho-educational interventions have not utilized JP-]symbolic modeling techniques and have not specifically focused on long-distance marriages. This study aims to examine the effectiveness of psycho-education using symbolic modeling techniques in enhancing the subjective well-being of long-distance married couples. An experimental matching control study design was used with 16 participants, divided into 8 in the experimental group and 8 in the control group. The subjective well-being scale was used as the instrument for data collection. Data analysis was conducted using the Wilcoxon signed Rank Test and the Mann-Whitney U Test. The results of the study show that psycho-education using symbolic modeling techniques is effective in enhancing the subjective well-being of long-distance married couples. Psycho-educational interventions with symbolic modeling can be used to help long-distance married couples achieve wellbeing, making their marriages more meaningful.
Authentic Happiness in Marriage: How Do Effective Communication and Positive Emotional Support Contribute?
Authors: Rizky Muhammad , Nurfarhanah Nurfarhanah , Karneli Yeni , Ardi Zadrian
Published: December 2024

In today’s marriages, a common issue is the lack of effective communication and positive emotional support, which can lead to divorce and impact authentic marital happiness. This study aims to explore the relationship between effective communication, positive emotional support, and authentic happiness in marriage. A total of 72 couples participated in this research, selected through purposive sampling. Criteria included a marriage duration of no more than 5 years and an age range of 19-40 years for partners, aligning with early adulthood developmental theory. Data were analyzed descriptively, followed by prerequisite analysis and hypothesis testing using regression analysis. The results indicate a significant relationship between effective communication, positive emotional support, and authentic marital happiness. These findings have practical implications for premarital counseling and guidance programs, offering a reference for counselors to inform couples about the importance of effective communication and positive emotional support.
Mental Health Conditions and Quality of Life among Online Gambling College Students: A Descriptive Study
Authors: Wulandari Devi , Saputra Dinar , Ardiansyah Zaidan
Published: December 2024

The phenomenon of online gambling is widespread among college students in Indonesia. However, little is known about its impact on their mental health and health-related quality of life. This study aimed to examine the mental health and quality of life of college students affected by online gambling. A cross-sectional survey was conducted with online questionnaires distributed to 118 students who had engaged in online gambling within the past 12 months. The Self-Report Questionnaire-20 (SRQ-20) and the 12-Item Short FormHealth Survey (SF-12) were used for assessment. Results showed that Mental ComponentSummary (MCS-12) scores were lower than Physical Component Summary (PCS-12)scores. Respondents reported issues such as sleep disturbances, difficulty enjoying daily activities, fatigue, decision-making struggles, lack of a sense of purpose, feelings of unhappiness and worthlessness, nervousness, and frequent worry. These findings suggest that online gambling may have a harmful effect on students' mental health and overall quality of life.
Parenting Styles and Student Resilience: The Role of Religiosity as a Mediator
Authors: Savira Alice Whita , Suprawati M.M. Nimas Eki , Ernest Justin
Published: December 2024

As one of the age groups vulnerable to depression, resilience is an essential aspect to consider among university students. Parenting styles are thought to play a role in the development of resilience; however, research findings on the relationship between these two variables remain inconsistent. In addition to parenting styles, religiosity has also been found to correlate with resilience. Religiosity is suspected to act as a mediator in the relationship between parenting styles and resilience. The role of religiosity as a mediator is important to examine, given that religiosity is a significant element in the lives of Indonesians. This study aims to investigate whether religiosity mediates the relationship between parenting styles and resilience. The instruments used in this study include the Parental Authority Questionnaire (PAQ) (α = 0.783 for the authoritarian parenting scale, α = 0.617 for the permissive parenting scale, and α = 0.830 for the authoritative parenting scale), the Centrality of Religiosity Scale (CRS) (α = 0.888), and the Connor-Davidson Resilience Scale (CD-RISC) (α = 0.920). A total of 412 university students in Indonesia participated in this study. Data analysis using GLM Mediation Analysis revealed that religiosity mediates the relationship between permissive parenting and resilience. Religiosity also mediates the relationship between authoritative parenting and resilience. A direct relationship between authoritative parenting and resilience was also identified. However, religiosity does not serve as a mediator in the relationship between authoritarian parenting and resilience. The implications of this study are discussed at the end of the article.
Adaptation and Psychometric Investigation of the Family Role Performance Scale
Authors: Fauziah Nailul , Sri Indrawati Endang , Dinardinata Adi
Published: December 2024

Family role performance refers to fulfilling responsibilities and expectations associated with various family roles. In urban Indonesia, changing gender roles and family dynamics have highlighted the importance of role division between spouses, but no studies have adapted a measurement tool into Indonesian. This study aims to adapt and test the psychometric validity of the Family Role Performance Scale by Chen et al. (2014) for Indonesian families, hypothesizing it will be a reliable tool. The research design is cross sectional, involving cultural adaptation and factor structure testing via Confirmatory Factor Analysis (CFA). Construct validity, convergent validity, and discriminant validity were also assessed. The sample consisted of 250 married couples, determined using a G-power of 0.8. Analysis results indicated that factor loading values above 0.5 demonstrate good validity and reliability, making the scale suitable for measuring role division in Indonesian families. These findings provide a reliable tool for assessing family role performance and supporting policies aimed at balancing family roles in a changing society.
Analysis of pharmaceutical technical staff needs at hospital X in Bandung using the WISN method
Authors: Elaine Angela Alysia , Wicaksono Imam Adi
Published: December 2024

One of the essential and inseparable health services in hospitals is pharmaceutical services. Pharmaceutical services in hospitals are carried out by the Hospital Pharmacy Installation (Instalasi Farmasi Rumah Sakit / IFRS). The implementation of pharmaceutical services in hospitals must be supported by adequate, skilled, and competent human resources so that pharmaceutical service activities can run well and are high quality for patients. The lack of human resources for pharmaceutical services will result in excessive workload and reduced quality of pharmaceutical services. One method widely used to determine the number of staff needs is the Workload Indicators of Staffing Needs (WISN). Analysis of the need for pharmaceutical technical staff at Hospital X in Bandung City was carried out using the WISN method. The data used for the analysis were obtained from interviews, observations, and data collection on pharmaceutical services from the pharmacy installation of the Hospital X. The results of the WISN analysis showed that the need for pharmaceutical technical personnel for central pharmacy installations providing outpatient and inpatient services is 87 people, the total need for the emergency room pharmacy satellite is 6 people, the operating room pharmacy satellite is 6 people, and the pharmacy warehouse is 3 people. From the results of WISN ratio, the number of pharmaceutical technical staff available for the central pharmacy installation, emergency room pharmacy satellite, and operating room pharmacy satellite are still inadequate for the existing workload (WISN ratio < 1). In contrast, for the pharmaceutical warehouse, it is adequate (WISN ratio = 1). Therefore, Hospital X needs to consider adding existing pharmaceutical technical staff to support more optimal pharmaceutical services at the hospital.
Enterobacter hormaechei: an endophytic bacterium found in Avocado Peel (Persea americana Mill.) with antioxidant properties
Authors: Rustini Rustini , Rahmi Khalila Rahmi , Putra Purnawan Pontana , Andayani Regina Andayani , Dwinatrana Khiky
Published: December 2024

Avocado peels (AVP) are renowned for their potent antioxidant properties, making them highly effective in preventing oxidation and free radical formation. Endophytes, microorganisms residing within plant tissues, have demonstrated the ability to produce novel compounds with remarkable biological activities. These bioactive compounds are sometimes even more potent than those found in their host plants. This study explores the potential of endophytes from avocado peels as rich sources of antioxidant compounds. AVP samples are collected, surface-sterilized, and segmented before being cultured in growth media. The bacteria are then isolated, purified, and subjected to ethyl acetate extraction to evaluate their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) microassay. Samples demonstrating favorable antioxidant properties undergo molecular identification through 16S rRNA gene sequencing. Four bacterial strains are successfully isolated, with only the APK4 strain exhibiting significant antioxidant activity with an IC50 value of 302.3 μg/mL. Molecular analysis and phylogenetic tree construction reveal that APK4 is closely related to the Enterobacter hormaechei species, with a percent identity value of 99.93%. These findings highlight the potential of active metabolites from endophytic bacteria in AVP extracts as promising lead compounds for the development of novel drugs, nutraceuticals, and cosmetic ingredients.
Optimization of self-nano emulsifying drug delivery system of rifampicin for nebulization using cinnamon oil as oil phase
Authors: Ricardo I Komang Aan Adi , Arimurni Dewa Ayu
Published: December 2024

Lung delivery can overcome the problems related to the effectiveness of tuberculosis treatment by increasing the drug concentration at the target site. Rifampicin as the first-line antibiotic for tuberculosis has low water solubility and is unstable in gastric which hinders its effectiveness. Self-nanoemulsifying drug delivery system (SNEDDS) is a strategy known to improve the solubility and stability of such drugs. This study aimed to obtain the optimum formula of rifampicin SNEDDS intended for lung nebulization using essential oil as an oil phase. Several essential oils are known to have effective antibacterial on Mycobacterium tuberculosis. However, a high capability to solubilize the drug is required for SNEDDS formulation. Cinnamon oil, tween 80, and transcutol P were chosen as SNEDDS components for optimization using a D-optimal mixture based on the physicochemical characteristics. The optimum formula comprised 12.65% cinnamon oil, 75.00% tween 80, and 12.35% transcutol P which dispersed easily to form a highly transparent emulsion in normal saline under 1 minute. Upon dilution with saline, the optimal SNEDDS can produce a homogenous nanometer droplet (169.2±19.771 nm, PDI of 0.258±0.070) with acceptable pH for lung administration. It also has a viscosity similar to water (0.94±0.01 cP) which allows it to be nebulized easily (aerosol output rate of 0.14±0.02 g/min). Although the diluted SNEDDS has a zeta potential of -2.533±0.268 mV, it was stable for up to 4 hours during the nebulization. These results indicate the potential of cinnamon oil-based rifampicin SNEDDS to be an alternative in the pulmonary delivery of rifampicin via nebulization.
Development of standardized green coffee bean extract (Coffea canephora) into effervescent granules as an antioxidant supplement
Authors: Wijaya Andre , Darsono Farida Lanawati , Foe Kuncoro
Published: December 2024

This study aimed to obtain the optimum formula of effervescent granules of green coffee extract (EG-GCE) on its physical quality (flow speed, water content, and dissolving granule time test) and effectiveness as an antioxidant. The dried extract was obtained by percolation of green coffee with water and dried using a spray drier. The dry extract will be standardized for specific and non-specific. The dose of the dried extract of green coffee used in the granule effervescent was 250 mg pr sachet. EG-GCE was formulated using wet granulation method. Effervescent granules were tested for physical quality (organoleptic, pH, moisture content, flow properties, and dissolving effervescent granule time test) and effectiveness, consisting of antioxidant activity (IC50) with the DPPH method using the microplate reader. The optimum effervescent granule formula was obtained using the factorial design method. The factors used were citric acid monohydrate with a level of (-1) 8% and a level of (+1) 12%, and tartaric acid with a level of (-1) 16%and a level of (+1) 24%. The determination of the optimum formula (proportion of citric acid monohydrate and tartaric acid) was carried out by factorial design method using the following responses: moisture content, flow rate, and dissolving effervescent granule time test. Furthermore, the One Way Anova (Yate's Treatment) statistical method will analyze data from parametric experiments between batches and between formulas. If there is a significant difference in the statistical analysis between the formulas, then the test is continued using the Tukey post-hoc test method. The pH value of resulting EG-GCE products was within the range of 5.46-6.07, moisture content: 3.12-3.67%, flow rate: 25.78-28.53 g/s, angle of repose: 25.65-30.130, Hausner ratio: 1.14-1.22, Carr's index: 12.50–17.83%, dissolving effervescent granule time test: 1.00-1.33 min. This study demonstrated that citric acid monohydrate, tartaric acid, and their interaction affected the moisture content, flow rate, and effervescent time of EG-GCE. The proportion of citric acid monohydrate (9.94%) and tartaric acid (17.46%) was found to be the optimum formula of EG-GCE, with the following responses: moisture content 3.26%, flow rate 25.72 g/s, and dissolving effervescent granule time test 1.19 min. The optimum formula show strong antioxidant activity with IC50 free of radical scavenging 56.56 ± 0.97 µg/ml.
Facility Layout Planning of Sheet Metal Working Industry Using Metaheuristics
Authors: Ludwika Adinda Sekar , Shalehah Mar’atus , Mohamad Rakan Raihan Ali , Oktavia Andiny Trie , Normasari Nur Mayke Eka , Tho Nguyen Huu , Rifai Achmad Pratama
Published: December 2024

The design of facility layout in a production floor determines the level of effectiveness and efficiency of the production process. Errors in arranging the layout in the production floor can disrupt the continuity of the production process and prevent optimal results. Production activities that occur over a long period of time make any inaccuracies in layout planning result in significant losses. In companies with Job Shop production type, which is characterized by identical products and varied processes, the production flow changes with each product made. Based on these issues, this research aims to optimize the layout in a company engaged in sheet metal working industry using metaheuristic algorithms such as Simulated Annealing (SA), Large Neighborhood Search (LNS), Adaptive Large Neighborhood Search (ALNS), and Ant Colony Optimization (ACO). The best total distance results were obtained by the SA, LNS, and ALNS algorithms, with a total travelled distance of 897,171 meters and a facility arrangement of 7-5-6-4-3-2-1 or 1-2-3-4-6-5-7. Additionally, considering computation time, the SA algorithm is the best choice as it has the fastest computation time compared to other algorithms.
Tabu Search Algorithm for Solving a Location-Routing-Inventory Problem
Authors: Saragih Nova Indah , Turnip Peri
Published: December 2024

Location decisions, inventory control, and vehicle routing are interrelated decisions. Inventory control decisions, such as order lot size and order frequency, affect both inventory and transportation costs. Failure to take inventory and transportation costs into consideration when determining location decisions can lead to suboptimality since they have a large impact on inventory and transportation costs.  Therefore, how to decide locations, determine vehicle routing, and control inventory optimally, or location-routing-inventory problem (LRIP), becomes an important issue to design logistics systems. The objective of this paper is to develop a heuristic method base on Tabu Search (TS) to solve a LRIP.  The contribution of this paper which is the heuristic method based on TS to solve a LRIP has never been developed before. TS is a type of metaheuristic. The success of TS is due to its ability to direct the search process so as not to get trapped in the local optimum, in large part, like many other metaheuristics. TS has been widely used to solve complex combinatorial optimization problems. The result of the computational comparison show that the heuristic method can provide a relatively small average gap of 3.20% compared to the optimal method. Application of the proposed heuristic is done in DKI Jakarta.
Optimization of Critical Thinking by Empowering Collaboration and Communication Skills through Information Literacy-Based E-Books: In STEM integrated Problem-Based Learning
Authors: Cintamulya Imas , Murtini Iin , Warli Warli
Published: December 2024

This study aimed to optimize critical thinking by empowering reflective and impulsive students' collaboration, communication, and information literacy skills through information literacy-oriented e-books in STEM-integrated problem-based learning (PBL). The research method used was a descriptive explorative approach. The study subjects consisted of five reflective students and five impulsive students. The measurement of cognitive style used the Matching Familiar Figure Test (MFFT) instrument. Collaboration skills were assessed through observation sheets, critical thinking and communication skills were assessed through student worksheets based on problem-solving tasks, and information literacy was assessed through a questionnaire. The study found that reflective students excelled in critical thinking and information literacy, while impulsive students demonstrated superior collaboration skills. As for communication skills, reflective and impulsive students have different advantages for each indicator of communication skills. This study can conclude that implementing information literacy-oriented e-books through STEM-integrated PBL can optimize reflective and impulsive students' critical thinking, collaboration, communication, and information literacy skills. The implication of this study is the importance of integrating 21st century skills holistically in learning practices, especially in the digital era, to prepare the younger generation to face the challenges of the 21st century.
A IDENTIDADE PROFISSIONAL NA PERSPECTIVA DA HUMANA DOCÊNCIA E O PAPEL DO PPP DA ESCOLA
Authors: Miranda de Lima Klebe , França de Morais Beatriz , Mara Rezende Machado Tânia
Published: December 2024

A partir das contribuições do Grupo de Estudos em Educação do Campo, Águas e Florestas nas Amazônias (Gecafa) liderado pela Profa. Dra. Tânia Mara Rezende Machado, o presente trabalho objetiva analisar como é possível que a identidade profissional do educador numa concepção de humana docência seja constituída a partir dos direcionamentos advindos do Projeto Político-Pedagógico (PPP) da escola, para, dessa maneira, apontarmos em que medida os projetos em disputa nos currículos da escola são e/ou podem ser reverberados na prática a partir dos seus PPPs. Para tanto fizemos uma pesquisa bibliográfica centrada nas categorias de humana docência e PPP da escola, tomando como referencial teórico Arroyo (2011) e Gadotti (2000). O estudo aponta para a necessidade de que a realidade desse gênero de formação humana, crítica e emancipadora advinda da concepção de humana docência se concretize nas práticas educativas.
MATERIAIS DIDÁTICOS VISUAIS E O ENSINO DE LIBRAS COMO ABORDAGEM CENTRADA NA PESSOAS SURDA
Authors: Cordeiro de Sousa e Lima Ritha , Kelly Gomes de Oliveira Alanna
Published: December 2024

O reconhecimento da Língua Brasileira de Sinais (Libras) pela Lei 10.436/02 como língua natural da comunidade surda brasileira, assegura o direito à instrução em sua língua nativa. No entanto, ainda há lacunas na criação de materiais didáticos visuais para o ensino de Libras como L1. Este estudo qualitativo e bibliográfico, a partir de autores como Strobel (2008); Marques (1999); Alves (2020), investigou nos periódicos da CAPES e UFPB (2013-2023) a produção de materiais visuais no ensino de Libras. A análise revelou uma presença tímida de pesquisas abordando a visualidade, aspecto essencial no ensino para pessoas surdas. Diante dos achados, o estudo apresenta materiais visuais desenvolvidos durante o curso de Letras Libras da UFCG, enfatizando a importância de práticas metodológicas que integrem a visualidade na aquisição da Libras, respeitando a subjetividade da comunidade surda.
APRESENTAÇÃO DO DOSSIÊ TEMÁTICO ESTUDOS EM LIBRAS
Authors: De Oliveira Alves Edneia , Cristina Silva Daxenberger Ana
Published: December 2024

Texto de apresentação
Investigation of the Metrological Properties of Magnetic Field Sensors Used in Popular Smartphones for the Shoe Size Determination System
Authors:   Warsaw University of Technology, Faculty of Mechatronics, Institute of Metrology and Biomedical Engineering, św. A. Boboli 8, 02-525 Warsaw, Poland, Gazda Piotr , Rękas Paweł , Frydrych Piotr , Nowak Paweł , Nowicki Michał , Szewczyk Roman
Published: December 2024

This article presents a study on the metrological properties of smartphone magnetometers and their application in determining the correct shoe size. The research focuses on using magnetometers in smartphones to measure the magnetic field generated by magnetic markers placed inside shoes. To measure foot dimensions, smartphone embedded position sensors and image analysis were employed to determine key foot parameters accurately. Measurements were conducted under controlled conditions using triaxial Helmholtz coils, which generated a precise magnetic field. Linearity, sensitivity, offset, and measurement uncertainty were evaluated in several popular smartphones. The results indicate that the accuracy of magnetometer measurements depends on the quality of the smartphone. Electromagnetic interference, especially in cheaper devices, can introduce noise that affects data quality. Extended averaging periods help reduce noise and improve measurement accuracy. Smartphone magnetometers can be effectively utilized for precise magnetic field measurements, provided the device is calibrated correctly and the measurement method is appropriately adjusted. Certain limitations, such as noise from electromagnetic interference and its impact on data quality, remain challenging. Nonetheless, the study’s findings are promising, especially in applications such as shoe sizing systems, where accurate measurements of the inside of the shoe are essential for a proper fit of the shoe to the foot.
Applying Enterprise Architecture to Analysis and Optimization of Production Control
Authors:   Politechnika Świętokrzyska, Al. Tysiąclecia P.P. 7, 25-314 Kielce, Juzoń Zbigniew , Wikarek Jarosław , Sitek Paweł
Published: December 2024

The classic approach to production control optimization usually comes down to building optimization and decision-making models based on data obtained directly from the production system from the so-called “technological layer”. Most often, economic factors that occur mainly at the level of the so-called „business layer”, which have a significant impact on the processes operating in the company, including the production process itself. In the process of building detailed production optimization models, it is necessary to take into account various variable factors also occurring at the „business layer” level, i.e. prices of services, prices of raw materials, contractual penalties, which may affect the directional decision in the production process, i.e. Should all orders be completed in your own production system? Will it be cheaper to outsource some orders/parts of orders? Proposing a different approach to optimizing the production process than before, using data from both the technological and business layers, may facilitate: identifying areas intended for optimization/automation of production processes, building detailed mathematical models for the purpose of optimizing/automating production processes and adapting information flow between individual layers (technological/business) operating at the enterprise level. The article presents the use of enterprise architecture to analyze the process of controlling the production of rolling bearings in a real factory and to build a mathematical model for optimization and decision support in this process.
Digital Maturity in Mapping the European Digital Innovation Hub Services
Authors:   Politechnika Wrocławska, Wydział Mechaniczny, Katedra Technologii Laserowych, Automatyzacji i Organizacji Produkcji, ul. Łukasiewicza 5, 50-371 Wrocław, Mazgajczyk Emilia , Pietrusewicz Krzysztof , Kujawski Krzysztof ,   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie, Al. Piastów 17, 70-310 Szczecin
Published: December 2024

European Digital Innovation Hubs provide a one-stop shop for entrepreneurs to support their digital transformation. A key challenge remains the formulation of a coherent vision and roadmap to set the direction of the transformation. Digital maturity models are a tool for identifying insights into the health of an enterprise and setting a path or roadmap for digital implementation. Determining the strategy for the development of the enterprise is to carry out a digital maturity assessment carried out according to the Digital Maturity Assessment Tool model. The strategic step is to tailor an appropriate service package for the enterprise under study. The article demonstrates the impact of the DMAT analysis results on the service package offered by EDIH. An example of service package mapping for a selected SME manufacturing company is presented. A metamodel of a tool for simulating service packages provided by the EDIH network is discussed. The paper consists of five parts, an introduction and a conclusion. Parts 2. and 3. are devoted to EDIH hubs and the services they offer, targeting SMEs. Part 4. discusses maturity models specific to reference architecture models and the suitability of their use for maturity assessment. Part 5. presents the S(d)MART metamodel and Part 6. presents an example of how maturity assessment can be practically linked to the services or service packages offered by the EDIH. The final section concludes the paper.
The Fractional Order Models of a Thermal Trace on a Heat-Insulating Surface
Authors:   AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Kraków, Oprzędkiewicz Krzysztof
Published: December 2024

The paper deals with a modeling of thermal trace at heat insulating surface with the use of two Fractional Order (FO) state space models. The fundamental distributed-parameter model was compared to simplified, lumped-parameter model, built with the assumption that the spatial heat transfer can be omitted. Such a comparison has not been presented yet. The simplifying assumption was confirmed experimentally in two ways. Firstly, the proposed lumped-parameter model assures the same accuracy in the sense of Integral Absolute Error (IAE) cost function as distributed-parameter model. Next, identified values of the heat transfer coefficient in the heat transfer equation are close to zero.