bluuebunny/crossref_metadata_2025 huggingface dataset:
SHROOM3 is a novel component of the planar cell polarity pathway whose disruption causes congenital heart disease
Authors: Schmidt Alison , Durbin, MS MD Matthew , O’Kane, MS James , Ware, MD PHD Stephanie M.
Published: January 2020

Congenital heart disease (CHD) is the most common cause of death due to birth defects. Despite CHD frequency, the etiology remains mostly unknown. Understanding CHD genetics and elucidating disease mechanism will help establish prognosis, identify comorbidity risks, and develop targeted therapies. CHD often results from disrupted cytoarchitecture and signaling pathways. We have identified a novel CHD candidate SHROOM3, a protein associated with the actin cytoskeleton and the Wnt/Planar Cell Polarity (PCP) signaling pathway. SHROOM3 induces actomyosin constriction within the apical side of cells and is implicated in neural tube defects and chronic renal failure in humans. A recent study demonstrated that SHROOM3 interacts with Dishevelled2 (DVL2), a component of the PCP signaling pathway, suggesting that SHROOM3 serves as an important link between acto-myosin constriction and PCP signaling. PCP signaling establishes cell polarity required for multiple developmental processes, and is required for cardiac development. In Preliminary data we utilized a Shroom3 gene-trap mouse (Shroom3gt/gt) to demonstrated that SHROOM3 disruption leads to cardiac defects phenocopy PCP disruption. We also demonstrate that patients with CHD phenotypes have rare and potentially damaging SHROOM3 variants within SHROOM3’s PCP-binding domain. We hypothesize SHROOM3 is a novel terminal effector of PCP signaling, and disruption is a novel contributor to CHD. To test this, we assessed genetic interaction between SHROOM3 and PCP during cardiac development and the ultimate effect on cell structure and movement. Heterozygous Shroom3+/gt mice and heterozygous Dvl2 +/- mice are phenotypically normal. We demonstrated genetic interaction between SHROOM3 and PCP signaling by generating compound heterozygous Shroom3+/gt ;Dvl2 +/- mice and identifying a Double Outlet Right Ventricle and Ventricular Septal Defect in one embryo. We also observed fewer compound heterozygous mice than anticipated by Mendelian rations (observed: 18.4%; expected: 25%; n=76), suggesting potential lethality in utero. Immunohistochemistry demonstrates disrupted actomyosin in the SHROOM3gt/gt mice, characteristic of PCP disruption. These data help strengthen SHROOM3 as a novel CHD candidate gene and a component of the PCP Signaling pathway. Further characterization of this gene is important for CHD diagnosis and therapeutic development.
Association Between IL6R Polymorphisms and Cachexia Phenotype in Patients with Pancreatic Ductal Adenocarcinoma
Authors: Polster Nicholas J. , Rupert Joseph E. , Young Andrew R. , Zimmers Teresa A.
Published: January 2020

Background: Cachexia, manifested as progressive adipose and muscle wasting, affects up to 80% of patients with pancreatic ductal adenocarcinoma (PDAC) and significantly increases morbidity and mortality. Increased inflammation is an underlying mechanism in almost all cases of cachexia. Trans-signaling of Interleukin-6 (IL-6) via the soluble form of its receptor (sIL6R) has been shown to promote inflammation. Certain polymorphisms of the IL6R gene such as rs2228145 (Asp358Ala substitution) are associated with increased levels of sIL6R. We hypothesize that patients with PDAC possessing IL6R alleles correlated with higher levels of circulating sIL6R will have increased systematic inflammation manifested as increased cachexia prevalence or severity.
Methods: DNA was extracted from prospectively collected blood samples acquired from patients with PDAC and from non-cancer controls. Genotype at the rs2228145 polymorphism was determined by TaqMan qPCR genotyping. The resulting genotypes (A/A, A/C, C/C) were compared against cachexia-related metrics, including presence of cachexia (>5% body weight loss in the prior 6-months), body mass index (BMI), BMI-adjusted weight loss grade (BMI-WLG), and muscle and adipose volumes calculated from height-adjusted surface areas obtained from CT scans at the level of the third lumbar vertebra.
Results: 83.3% of patients with PDAC heterozygous (A/C) and 84.6% of the patients homozygous for the rs2228145 polymorphism (C/C) exhibited cachexia, versus 57.9% of patients homozygous for the reference allele (A/A), (P = 0.0364, Chi-square test). No significant difference was found among genotypes for BMI, 6-month weight loss, BMI-WL grade, or muscle and adipose tissue indices.
Conclusion: Patients with PDAC who are possess at least one copy of the rs2228145 polymorphism have a higher incidence of cachexia than those who are homozygous for the reference allele. This association suggests a causal role for sIL6R in cancer cachexia.
Anthropic transformation in the Gurupi river basin, eastern Amazon
Authors: Pereira Fabiana da Silva , Vieira Ima Célia  Guimarães
Published: January 2020

The objective of this paper was to evaluate the degree of anthropic transformation of a river basin in the Amazon region. We used the digital data of the TerraClass Project to calculate the Anthropic Transformation Index - ATI. In order to verify spatial and temporal changes along a decade in the Gurupi river basin, we used the database of the years 2004 and 2014. The results showed an increase of anthropic changes in the basin over a decade, as a result of forest cover conversion into agricultural and pastures areas. Although the Gurupi river basin remains at a regular level of degradation after a decade, the intensification of land use and land cover change is a threat to the few rainforest remnants of the river basin, which can lead the region to the next level of degradation, if effective forest protection, conservation and restoration actions are not implemented in the region.
The impact of the Brumadinho dam failure in Naô Xohâ village
Authors: Silva Adriana Aparecida , Lunas Divina Aparecida Leonel , Bicalho Poliene Soares dos Santos , Maciel Roseli Martins Tristão
Published: January 2020

It is still under strong impact from the Brumadinho dam failure that this article was written. Our main goal is to approach, in the midst of so many social groups hit by this announced tragedy, the reality of the village Naô Xohã, whose population lives on the banks of the Paraopeba River, also victimized by this environmental disaster of consequences not yet dimensioned. As it is a contemporary theme, several press releases were used to compose the narrative, as well as to build a comprehensive review of the literature on the Movement of People Affected by Dams and on socioeconomic and environmental impacts. The proposition, however, is based on an interdisciplinary approach to the theme, which is the impact of the Brumadinho dam failure in Naô Xohã village, mainly due to the pollution that spread over the Paraopeba River. To this end, a fruitful dialogue was established between history, geography, economics and environmental issues.
Investigating Satisfaction Levels of Safety Requirements in Mobile Cranes and its Relationship with Organization’s Safety Culture
Authors: Asivandzadeh Ehsan , Jamalizadeh Zeynab , Mohebi Afshin , Yari Peyman
Published: January 2020

Background: disregarding safety requirements has made accidents of workshop mobile cranes as one of the main factors of injuries and death in civil-industrial projects. Since safety culture considered one of the most important activist indices while investigating the commitment of superior managers and other members of the organization to regard safety requirements, the present study aims at investigating the organization’s safety culture in civil and industrial projects and its relationship with regarding safety requirements of mobile cranes. Methods: the current study is descriptive-analytical and cross-sectional research conducted within 7 civil-industrial projects from 2018 to 2019. To investigate satisfaction levels of safety requirements, 141cranes have been used through a 72-item researcher-made checklist adapted from ASME B30.5 2018 standard and protective regulation of transportation vehicles and moving materials and objects of workshops. The research team has confirmed the validity and reliability of the checklist with CVR=0.68, CVI=0.82, and Cronbach’s alpha=α-0.90. To estimate safety culture levels 677 individuals of staff such as cranes operator, technician, expert, minor managers, middle managers, and superior managers have participated in this study through random sampling method, interview, and completion of safety culture questionnaire. To analyze data Kolmogorov-Smirnov tests, one way ANOVA and linear regression utilizing SPSS v25 have been employed (P-value < 0.05). Results: age average of study individuals equaled with 39.8 and average of their work experiences equaled with 12.29. Results out of this study revealed that there is a positive and meaningful relationship between organizations’ safety culture and consideration levels of safety requirements in mobile cranes. So that parameter of management commitment (0.001), safety preference degree (0.004), staff training (0.012) and information exchange level (0.041) have the most relationship with consideration levels of safety requirements. But there was no meaningful relationship between work conditions and consideration levels of safety requirements (0.075). conclusion: based on results of this study it seems that accidents resultant from mobile cranes occur more in uncommitted organizations so it is important to develop organizations’ safety culture through performance of academic interventions and inform organizations’ staff especially superior management and consequently increase the safety factor of mobile cranes in civil-industrial projects.
The Effect of Ergonomic Educational Intervention on Reducing Musculoskeletal Disorders among Nurses
Authors: Mohammadi Samaneh , Halvani Gholam Hossein , Mehrparvar Amir Houshang , Jambarsang Sara , Anoosheh Vida sadat
Published: January 2020

Background: Nurses are subjected to musculoskeletal disorders for the reason of working situations and pressures, which any neglect of them causes a poor quality of hospital services provided to the patients. So, the present study was conducted to develop and evaluate the intervention based on the educational and reduction of musculoskeletal disorders among nurses of Khansar Fatemieh Hospital. Methods: This descriptive-analytical study was carried out on 74 nursing staffs of Fatemieh Hospital, Khansar, Iran, who were studied completely as the whole census. Inclusion criteria were nurses who were responsible for patient transmission, with more than one year of work experience and without a case history of musculoskeletal disorders. Exclusion criteria were surgery or accident while studying as well as disinclination to continue taking part in the study. Initially, the prevalence of musculoskeletal disorders was investigated by Nordic Questionnaire and Occupational Risk Factors by Rapid Body Assessment Technique (REBA). Evaluation criteria for the impact of training consisted of training such as film, pamphlets, handouts, informing in telegram channels, etc. Ultimately, after three months of training courses, the workstation was re-assessed through the above methods, and the data were analyzed through SPSS software version 16, Chi-square statistical tests, McNemar and Wilcoxon tests; then the effectiveness of the educational intervention was identified. Results: The mean age and work experience of the participants were 5.27 (32.83)and 4/55 (7.83) year respectively. The results illustrated that the highest rate of prevalence of musculoskeletal disorders was pertinent to the waist (64.90%) and knee (62.20%), wrist (50/00%) in order. The results obtained from the REBA technique indicated that 89.20% of participants were above the range of risk average. After the intervention, statistical tests exhibited a significant reduction in scores and level of risk achieved by the REBA technique (p-value<0/05). Also, the results stated that there was a significant reduction in musculoskeletal pains in the areas of the neck, shoulder, and knee after the intervention (P-value<0.05). But no perceptible change could be observed in the other kinesthetic organs of the body (P-value>0.05).  No significant relationship could be seen between gender, work experience, BMI (Body Mass Index) and prevalence of musculoskeletal disorders (P-value>0.05) in this study, but the statistical tests indicated that there was a significant relationship between age and pain in wrist area (P-value<0.05). Conclusion: The results offer that if preventative ergonomic training is part of multidisciplinary interventions and is presented through training such as film, pamphlets, pamphlets, handouts, informing in telegram channels and etc., it may have more influence on the reduction of musculoskeletal disorders.
Risk Factors Affecting Occupational Accidents and Related Causes: Case Study
Authors: Shabgard Zohreh , Moradirad Rohadin , Mousavi Seyed Mahdi
Published: January 2020

Background: Electricity is considered as the fifth cause of occupational deaths. Occupational accidents caused by electricity do not form a high percentage of total occupational accidents, but are considered due to the severity of injuries which often result in death. The present study aimed to investigate the factors affecting occupational accidents among employees of a power distribution company in Khuzestan province. Methods: The present study was a descriptive-analytical study which conducted as cross-sectional on the files related to the accidents of the personnel of a company in 2017.  Inclusion criteria were a history of accidents during the last 5 years from 2013 to 2017. Thus, all the personnel files of the employees of the company were reviewed and a number of 92 files of the personnel who were injured during the above-mentioned years were extracted. The required information such as demographic information (age, marital status, education level), organizational information of the injured person (employment status, job title), type of injury and place of injury on the body, rate of accidents in different seasons, days, and hours were recorded on a specific worksheet in the files. SPSS software version 22 was used for analyzing the factors affecting occupational accidents using descriptive tests and chi-square test. Significance level was considered as 0.05. Results:The maximum number of accidents occurred in summer during 8 to 10 am and the age group of 25 to 29 years reported the highest number of fatalities. In addition, most accidents occurred in the occupational group having a job experience of 1 to 5 years. Conclusion: Human errors and non- use of personal protective equipment, deficit of equipment and supervision, as well as the failure in implementing technical and safety instructions were the most critical causes of accidents and the actions such as technical and safety training before starting the work were evaluated as effective measures in controlling accidents.
Uncertainty Assessment of Quantitative Measurements in Medical Imaging: Applications in Cross-Sectional and Longitudinal Diffusion MRI
Authors: Nazem-Zadeh Mohmmadreza
Published: January 2020

The article's abstract is no available.
Application of Functional Magnetic Resonance Imaging in Neurolinguistics: A Systematic Review
Authors: Joodi Nayereh , Rahmani Farzaneh
Published: January 2020

The article's abstract is no available.
The FluoVision System for Fluorescence Concentration Imaging
Authors: Ebrahimi Seyyed Mohsen , Seydi Mojtaba , Ebrahimi MahyaSadat , Hejazi Marjaneh
Published: January 2020

Purpose: In this report the design concept and experimental evaluation of the performance of FluoVision have been illustrated.
Methods: The FluoVision system designed for fluorescence concentration imaging. In order to assess the capability of the system, results of reference design have been analyzed.
Results: Results of the FluoVision system are matched with the reference design.
Conclusion: The evaluation indicated that FluoVision is adequate as a fluorescence imaging system for fluorescence concentration imaging.
Surveillance of antibiotic resistance among uropathogens in Aljouf region northern Saudi Arabia
Authors: Taher Ibrahim , Almaeen Abdulrahman , Aljourfi Hassan , Bohassan Eyad , Helmy Ahmed , El-Masry Eman , Saleh Baraka , Aljaber Nawaf
Published: January 2020

Background and Objectives: Urinary tract infections are common health problem affecting millions worldwide. Antibiotic resistance among uropathogens (Ups) is prevalent in many countries. In the absence of any available data in the region, this hospital-based study investigated the pattern, frequency and susceptibility of Ups at Prince Mutaib Bin Abdulaziz Hospital, Aljouf Region, Saudi Arabia.
Materials and Methods: A retrospective assessment of UPs and their antibiotics susceptibility was conducted from January
2017 to December 2017 using the fully automated Vitek2 system (BioMérieux, France).
Results: Among the 415 uropathogens isolates, the most prevalent bacteria were Gram-negatives comprising 137 (51%) E. coli; 46 (17.2%) Klebsiella spp.; 30 (11.2%) Pseudomonas spp.; 25 (9.3%) Proteus spp.; 14 (5.2%) Acinetobacter baumanii and 16 (5.9%) others. On the other hand, Enterococcus spp. were predominant among Gram-positive isolates representing
54 (36.7%), 47 (32.0%) Staphylococcus spp., 22 (15.1%) Streptococcus spp., and 13 (8.8%) S. aureus, and 11 (7.5%) others. Gram-negative Ups showed multidrug resistance towards the majority of the tested antimicrobials (ampicillins, cephalospo- rins, fluoroquinolones, trimethoprim-sulfamethoxazole, fosfomycin, aztreonam, and nitrofurantoin). While high resistance patterns by Gram-positives was also seen against cephalosporins, penicillins, amoxicillin-clavulanic acid, trimethoprim-sul- famethoxazole, clindamycin, erythromycin and tetracycline.
Conclusion: The observed widespread multidrug resistance clearly warrant implementing stricter control measures, local guidelines of antimicrobials usage, and continuous epidemiological surveys at hospitals and communities.
Molecular characterization of quinolone resistant Shigella spp. isolates from patients in Ardabil, Iran
Authors: Teimourpour Roghayeh , Babapour Behnam , Esmaelizad Majid , Arzanlou Mohsen , Peeri-Doghaheh Hadi
Published: January 2020

Background and Objectives: Shigella is an etiological agent of shigellosis. Antibiotic therapy has a critical role in decreas- ing serious complications of shigellosis. The present study aimed to determine the multi-drug resistance strains and to detect fluoroquinolone related mutations.
Materials and Methods: In this descriptive, cross sectional study, a total of 113 Shigella isolates were collected from 1280 patients admitted to Bu-Ali hospital in Ardabil province during 2015-17. Antibiotic resistance pattern of isolates was evalu- ated using Kirby Bauer method and finally, the MICs of ciprofloxacin were determined. In order to determine any mutations in QRDR region, parC and gyrA genes of resistant strains were amplified and sequenced.
Results: Shigella spp. isolates were identified using ipaH amplification and rfc and wbgz genes were used for molecular detection of S. flexneri and S. soneii, respectively. Our results showed that the predominant species in Ardabil province was S. sonnei (69.91%). Most of isolates (82%) were resistant to trimethoprim/sulfamethoxazole (TMP/SMX); 51% were nali- dixic acid resistant and 4.4% were floroquinolones resistant. All examined isolates were susceptible to imipenem (100%). Mutation in gyrA and parC genes were detected in all fluoroquinolone resistant isolates (5 isolates). Although, in this study the rate of resistance to ciprofloxacin was low, but in the lack of preventive strategy it will be a major challenge of public health in future.
Conclusion: This study provided information on the prevalence and antimicrobial susceptibility patterns of Shigella isolates in Ardabil province, Iran. Also this study showed a high-level of resistance to commonly used antibiotics among Shigella isolates.
The potency of luliconazole against clinical and environmental Aspergillus nigri complex
Authors: Hivary Sahar , Fatahinia Mahnaz , Halvaeezadeh Marzieh , Mahmoudabadi Ali Zarei
Published: January 2020

Background and Objectives: Black Aspergillus strains including, Aspergillus niger and A. tubingensis, are the most cause
of otomycosis with worldwide distribution. Although, amphotericin B was a Gold standard for the treatment of invasive
fungal infection for several decades, it gradually replaced by fluconazole and /or voriconazole. Moreover, luliconazole,
appears to offer the best potential for in vitro activity against black Aspergillus strains. The aim of the present study was
to compare the in vitro activity luliconazole, with commonly used antifungals against clinical and environmental strains of
black Aspergillus.
Materials and Methods: Sixty seven (37 clinical and 30 environmental) strains of black Aspergillus were identified using
morphological and molecular technique (β-Tubulin gene). In addition, antifungal susceptibility test was applied according to
CLSI M38 A2. The results were reported as minimum inhibitory concentration (MIC) or minimum effective concentration
(MEC) range, MIC50 or MEC50, MIC90 or MEC90 and MIC geometric (GM) or MECGM.
Results: Aspergillus niger was the common isolate followed by, A. tubingensis in both clinical and environmental strains.
The lowest MIC range, MIC50, MIC90, and MICGM was attributed to luliconazole in clinical strains. The highest resistant rate
was found in amphotericin B for both clinical (86.5%) and environmental (96.7%) strains whereas 54.1% of clinical and 30%
of environmental isolates were resistant to caspofungin. Clinical strains of Aspergillus were more sensitive to voriconazole
(86.7%) than environmental strains (70.3%). On the other hand, 83.8% of clinical and 70% of environmental isolates were
resistant to posaconazole.
Conclusion: Luliconazole versus amphotericin B, voriconazole, posaconazole and caspofungin is a potent antifungal for
Aspergillus Nigri complex. The in vitro extremely antifungal efficacy against black Aspergillus strains of luliconazole, is
different from those of other used antifungals.
Primary tonsillar tuberculosis: a forgotten clinical identity
Authors: Motahari Seyyed Jafar , Afshar Parvaneh , Ghasemi Maryam , Vahedi Larijani Lale , Sheidaei Somayeh
Published: January 2020

Primary tonsillar tuberculosis is an uncommon entity and a diagnostic challenge. Misdiagnosis can be prevented with early
professional para-clinical finding. The true diagnosis is often delayed and infection management depends on recognizing
disease patterns and early laboratory documentation.
This rare clinical caseation granuloma with positive clinical symptoms, negative results of radiology/laboratory and alone
based on histopathological finding without any Mycobacterium particle indicates the role of an accurate laboratory/pathology
finding for urgent medical intervention treatment and lifesaving of patients, particularly in immunocompromised group.
IMPLEMENTAÇÃO DA POLÍTICA DE ATENDIMENTO ÀS PESSOAS COM NECESSIDADES EDUCACIONAIS ESPECÍFICAS NOS INSTITUTOS FEDERAIS BRASILEIROS
Authors: Lisboa Roselia Rodrigues dos Santos , Mendes Vera Lúcia Peixoto Santos , Lima Wandillson Alisson Silva
Published: January 2020

O objetivo deste estudo é analisar as estratégias de implementação da Política de Atendimento às Pessoas com Necessidades Educacionais Específicas(NAPNEs) nos Institutos Federais brasileiros, a partir da política formulada. Através de uma pesquisa de campo com aplicação de questionários aos coordenadores de 29 NAPNEs e análise documental dos marcos regulatórios sobre educação inclusiva, o estudo conclui que essas políticas necessitam de estratégias de implementação que incorporem: maior disponibilização de recursos financeiros, humanos e de infraestrutura; presença de equipes multidisciplinares; existência de servidores capacitados e específicos; autonomia na contratação de profissionais especializados; acesso a programas de computador para deficientes visuais e livros didáticos em Braile; e outros. Propõe ainda, aos governantes, legisladores e usuários uma [re]formulação das políticas de educação inclusiva.Palavras-chave: Política Pública. Implementação. Atendimento educacional especializado. Núcleos de atendimento às pessoas com necessidades educacionais específicas.IMPLEMENTATION OF THE POLICY ATTENDANCE TO PEOPLE WITH SPECIFIC EDUCATIONAL NEEDS IN THE BRAZILIAN FEDERAL INSTITUTESAbstractThe research’s goal is to analyze the strategies of implementation of the Policy of Assistance to People with Specific Educational Needs (NAPNEs) in the Brazilian Federal Institutes, based on the policy formulated. A field survey was carriedout with the application of questionnaires to the coordinators of 29 NAPNEs and documentary analysis of the regulatory frameworks on inclusive education. These policies need implementation strategies that incorporate: greater availability of financial, human, and infrastructure resources; presence of multidisciplinary teams; existence of trained and specific servers; autonomy in hiring specialized professionals; access to computer programs for the visually impaired and textbooks in Braille; and others. It proposes to governments, legislators and users a [re] formulation of inclusive education policies.Keywords: Public Policy. Implementation. Specialized educational attendance. centers for assistance to people with specific educational needs.
SOCIEDADE CIVIL E BASES DA EDUCAÇÃO: novo tempo para manifestos ou manifestos para novo tempo?
Authors: Freitas Urânia Flores da Cruz
Published: January 2020

Este artigo evidencia historicamente as desigualdades e as ações da sociedade civil inscritas nos manifestos da educação brasileira. Advindo de estudo teórico, pesquisa bibliográfica e documental tem por objetivo analisar como este Ator Rede entendeu e reagiu ao processo de desenvolvimento brasileiro e suas relações no campo da educação. Aponta que os escritos serviram de aporte para a compreensão da conjuntura de cada tempo histórico, pois trazem o cenário em que se inseriram as lutas e as conquistas. Revela como esses atores perceberam ou não as bases que estruturaram a educação no Brasil, como também, a importância dos instrumentos políticos de ação pública. Enfatiza como o movimento histórico das bases de estruturação educacional e social ajuda a pensar a atualidade política. Palavras-chave: Desenvolvimento. Manifestos da educação. Sociedade civil. Desigualdades. Ação pública.CIVIL SOCIETY AND THE BASIS OF EDUCATION: new time for manifestos or manifestos for a new time?AbstractThis article evidences historically the inequalities and the actions of the civil society inscribed in the Brazilian education manifestos. Based on a theoretical study, bibliographical and documentary research, it aims to analyze how this ActorNetwork understood and reacted to the Brazilian development process and its relations in the field of education. It points out that the writings served as a contribution to the understanding of the conjuncture of each historical time because they bring the scenario in which they entered, the struggles and the achievements. It reveals how these actors perceived or not the basis that structured education in Brazil, as well as the importance of the political instruments of public action. It also emphasizes how the historical movement of the basis of educational and social structure can contribute on reflect upon the current political time.Keywords: Development. Education manifestos. Civil society. Inequalities. Public action.
TRABALHO E EDUCAÇÃO: algumas considerações sobre as mudanças no mundo do trabalho e a expansão do ensino superior da rede privada de Manaus/AM
Authors: Oliveira Selma Suely Baçal de , Corrêa Elourdiê Macena
Published: January 2020

O texto trata das mudanças no mundo do trabalho a partir das últimas décadas do século XX, a expansão do ensino superior na rede privada da cidade de Manaus e a absorção da mão de obra no setor produtivo das indústrias do Polo Industrial de Manaus (PIM). O ensaio é de caráter bibliográfico e foi produzido à luz das leituras e debates propiciados pela disciplina Trabalho, Educação e Novas Tecnologias do programa de Pós-Graduação da Universidade Federal do Amazonas - PPGE/UFAM. Está dividido em três partes: a primeira trata das mudanças no mundo do trabalho; a segunda faz uma incursão sobre o processo de desenvolvimento histórico da Escola e o seu papel para a “qualificação” ao trabalho no trato das relações de produção, reprodução e a acumulação do capital e a terceira tece considerações sobre o Estado Neoliberal e seu ideário de “mercado livre”. Palavras-chave: Trabalho. Qualificação. Ensino Superior.WORK AND EDUCATION: some considerations about the changes in the world of work and the expansion of Higher Education of the private network of Manaus / AmAbstractThe text deals with the changes in the world of work since the last decades of the twentieth century, the expansion of higher education in the private network of the city of Manaus and the absorption of manpower in the industrial sector of the Polo Industrial Manaus (PIM) . The essay is a bibliographical one and was produced in the light of the lectures and debates offered by the discipline Work, Education and New Technologies of the Postgraduate Program of the Federal University of Amazonas - PPGE / UFAM. It is divided into three parts: the first deals with changes in the world of work; the second makes an incursion into the historical process of development of the School and its role for the "qualification" to the work in the relations of production, reproduction and the accumulation of capital and the third weaves considerations on the Neoliberal State and its ideology of "free market".Keywords: Work. Qualification. Higher education.
AVALIAÇÃO DE POLÍTICA PÚBLICA PARA HOSPITAIS DE PEQUENO PORTE: um referencial para a efetividade
Authors: Costa Maria Olivia , Sales Ricardo Viana
Published: January 2020

O presente artigo tem como objetivo descrever o processo de avaliação de uma política pública, através do estudo de caso do hospital municipal de pequeno porte do município de Quijingue no estado da Bahia.  Utiliza o método dedutivo, com a coleta indireta dos dados, através de pesquisa documental e bibliográfica que fundamentaram o tema. Divide o estudo em três etapas: a primeira busca definições e conceitos acerca da Política Nacional de Hospitais de Pequeno Porte (PNHPP); a segunda sobre um referencial teórico de avaliação de políticas públicas; e a terceira etapa relata o estudo de caso do HPP do município de Quijingue (BA) para as considerações finais.Palavras-chave: Avaliação. Política Pública. Hospital de pequeno porte. Saúde.PUBLIC POLICY EVALUATION FOR SMALL HOSPITALS: a benchmark for effectivenessABSTRACTThis article aims to describe the process of evaluation of a public policy, through the case study of the small municipal hospital of the municipality of Quijingue in the state of Bahia. The deductive method was used, with an indirect collection ofthe data, through documentary and bibliographic research that underlies the theme. The study was divided in three stages: the first search and concept about the National Policy of Small Port Hospitals (PNHPP); a second on a theoretical framework for evaluating public policies; and the third step reports the case study of the HPP of the municipality of Quijingue (BA) forthe final considerations.Keywords: Evaluation. Public Policy. Small hospitals. Health.
O JUDICIÁRIO E AS FUNÇÕES ESSENCIAIS À JUSTIÇA COMO SUJEITOS DE POLÍTICAS PÚBLICAS
Authors: Silva Maria Ozanira Silva e , Vasconcelos Roberta Silva
Published: January 2020

O artigo, referenciado em pesquisa bibliográfica e documental, objetiva abordar de que forma o Poder Judiciário e as funções essenciais à justiça contribuem na formulação e implementação de políticas públicas. Destaca-se o papel de “mediador” deste Poder, para atenuar situações de descumprimento de direitos, no exercício do seu papel de redimensionador do processo de tais políticas. Busca-se destacar o Neoconstitucionalismo para construção do protagonismo judicial nas políticas públicas, bem como estabelecer relação com princípios constitucionais que fundamentam a atuação do Judiciário e de outras instâncias que exercem funções de justiça nas políticas públicas.  Conclui-se pela relevância das ações da Justiça para corrigir ineficiências ou insuficiências na implementação de políticas públicas, buscando garantir direitos constitucionais e, principalmente, a dignidade da pessoa humana.Palavras-chave: Judiciário. Políticas Públicas. Princípio de separação de poderes. Princípio da reserva do possível.THE JUDICIARY AND THE ESSENTIAL FUNCTIONS TO JUSTICE AS SUBJECTS OF PUBLIC POLICIESAbstractThe article, referenced in bibliographical and documentary research, aims to address how the Judiciary and the essential functions of justice contribute to the formulation and implementation of public policies. It emphasizes the role of "mediator" of this Power, to mitigate situations of noncompliance of rights, in the exercise of its role of resizing the process of such policies. It seeks to emphasize Neo-constitutionalism for the construction of judicial protagonism in public policies, as well as establishing a relationship with constitutional principles that support the work of the Judiciary and other institutions that exercise justice functions in public policies. It is concluded that justice actions are relevant to correct inefficiencies or deficiencies in the implementation of public policies, seeking to guarantee constitutional rights and, above all, the human dignity.Keywords: Judiciary. Public policies. Principle of separation of powers. Principle of reservation of the possible.
PARTICIPAÇÃO E DELIBERAÇÃO NA GESTÃO PÚBLICA: desafios e potencialidades dos Fóruns Regionais de Governo
Authors: Brasil Flávia de Paula Duque , Carneiro Ricardo , Anelli Fernando Resende , Longuinho Luísa de Paulo
Published: January 2020

Os Fóruns Regionais de Governo de Minas Gerais foram criados em 2015 com a intenção de viabilizar um canal para as demandas provenientes da população das diferentes regiões do estado. A nova instância participativa se desenvolveu nos últimos quatro anos, sob o slogan do governo de Minas Gerais (2015-2018) de “ouvir para governar”. O presente trabalho teve como objetivo analisar características centrais do desenho institucional e do processo participativo, a partir das reflexões teóricas de Fung e Wright (2003) sobre a Empowered Participatory Governance e de Tarragó, Brugué e Cardoso Jr. (2015), a respeito da construção de uma Administração Pública Deliberativa. Na análise, foram identificados potencialidades e desafios na implementação dos Fóruns Regionais de Governo (2015-2018) e levantadas reflexões sobre sua consolidação como inovação democrática no modelo mineiro de gestão.  Palavras-chave: Participação social. Administração pública deliberativa. Desenho institucional participativo. Inovação democrática. Fóruns Regionais.PARTICIPATION AND DELIBERATION IN PUBLIC MANAGEMENT: challenges and potentialities of the Regional Government ForumsAbstractThe Minas Gerais Regional Government Forums were created to provide a channel for the demands of the population of the different regions of the state. The new participatory instance has developed, over the past four years, under the slogan of the Minas Gerais government (2015-2018) of "listening to govern". The objective of this study was to analyze the central characteristics of the institutional design and the participatory process, based on the theoretical reflections of Fung and Wright (2003) on Empowered Participatory Governance and Tarragó, Brugué and Cardoso Jr. (2015) on the construction ofa Deliberative Public Administration. In the analysis, were identified potentialities and challenges in the implementation of the Regional Government Forums and raise reflections on its consolidation as a democratic innovation in the Minas Gerais management model.Keywords: Social participation. Deliberative public administration. Participatory institutional design. Democratic innovation. Regional Forums.
Developing Intercultural Communication Competencies Using Various Learning Methods at a Media Communications Study Programme
Authors: Vukić Tijana , Zelenik Marijana , Welzer Tatjana
Published: January 2020

Various previous researchers of journalism and media communication education demonstrated the necessity and importance for media workers to be competent in intercultural communication (IC). Slovenian researchers do not discuss these topics, and IC themes are withal mostly part of a non- obligatory courses where usual teaching and learning methods are applied. To examine the effectiveness and usefulness of different teaching/learning methods in developing students’ intercultural communication competencies, an educational intervention research was suitable, as the method is being useful mostly to solve pragmatic issues. Additionally, the study aimed at determining outgoing students’ intercultural communication competencies (ICC) – knowledge, skills, attitudes, and awareness through their cognitive, affective and behavioural dimensions. Two theoretical approaches were used – one stating that ICC are developed by learning on the ground of our innate predispositions and character and the behavioural perspective. This qualitative-evaluative research was conducted within the International and Intercultural Communication course at the first year of Graduate Study of Media Communications at the University of Maribor. It was a trilingual intercultural situation where learning activities such as role-playing, pantomime, case studies, simulations, individual exploration, and reflection were implemented, since students were not used to them. Participatory observation, semi-structured interviews, qualitative questionnaires, evaluation of class activities and a final exam were used as main research methods. Even though the group adapted very soon, the nonverbal activities were most demanding, and individual activities at home the least accomplished. Although they had theoretical knowledge, experience in public speaking, proactivity and self-reflection skills at basic level, their abstract thinking skills, self-awareness and adaptation were medium. However, they showed a great deal of persistence and creativity as a part of a collaborative and cooperative activities. Therefore, focusing on the learning activities stimulating students’ ICC as a part of a real intercultural situation in journalism and mass communication (JMC) education is recommended.
Od redaktorki: Osiąganie dorosłości i młodzi dorośli jako kategorie analiz socjologicznych
Authors: Grotowska-Leder Jolanta
Published: January 2020

Przebieg życia obejmujący trzy podstawowe fazy – młodość, dorosłość, starość – wyraźnie komplikuje się w społeczeństwie ponowoczesnym, szczególnie w okresie tranzycji z młodości do dorosłości. Niepokojąco wydłuża się proces stawania się dorosłym. Młodzi ludzie coraz później osiągają pełną dorosłość obejmującą niezależność ekonomiczną poprzez stałą pracę, niezależność społeczną w rozumieniu samodzielnego zamieszkania i prowadzenia gospodarstwa domowego oraz założenia rodziny. Zawarte w tomie teksty prezentują rezultaty badań socjologicznych dotyczących tego złożonego zjawiska, które jest skutkiem oddziaływania globalnych procesów, strukturalnych uwarunkowań funkcjonowania młodych ludzi i ich indywidualnych wyborów.
Młodzi dorośli łodzianie i zduńskowolanie zaangażowani w sferę i przestrzeń publiczną w procesie osiągania pełnej dorosłości
Authors: Kotras Marcin
Published: January 2020

W tekście zaprezentowano wyniki zogniskowanych wywiadów grupowych przeprowadzonych z młodymi dorosłymi, którzy osiągali pełnoletniość około 2004 roku i którzy działają w sferze publicznej i politycznej. Problematyka badania skoncentrowana była na zagadnieniach dotyczących aktywności w sferze i przestrzeni publicznej w trakcie procesu osiągania pełnej dorosłości. Artykuł rozpoczynają ustalenia dotyczące zakresu problematyki badania, jego organizacji i ram teoretycznych. W dalszych częściach omówiony został materiał zebrany w trakcie zogniskowanych wywiadów grupowych. Spostrzeżenia dotyczą procesu wchodzenia w rolę działacza społecznego oraz diagnozy przyczyn braku angażowania się młodych dorosłych w kwestie publiczne.
Nonconvulsive status epilepticus in the course of Hashimoto’s encephalopathy – case report
Authors: Rauszer-Szopa Agata , Gajewska Gabriela , Kapcia Katarzyna , Szewczyk-Urgacz Danuta
Published: January 2020

Encefalopatia Hashimoto (EH) jest rzadkim zespołem neurologicznym, mogącym towarzyszyć chorobie Hashimoto albo występować niezależnie od niej. Spektrum objawów – szerokie i niecharakterystyczne – utrudnia proces diagnostyczny. Encefalopatię Hashimoto mogą przypominać wszelkie choroby związane z zespołem majaczenia i szybko postępującym otępieniem, dlatego przedstawiony w pracy opis przypadku jest istotny dla lekarzy wszystkich specjalności. Większość pacjentów znajduje się w stadium eutyreozy. Przebieg choroby może być ostry udaropodobny lub z przewagą objawów psychiatrycznych i z napadami padaczkowymi. Rozpoznanie stawia się najczęściej poprzez wykluczenie innych przyczyn zaburzeń neurologicznych oraz stwierdzenie encefalopatii i wysokiego miana przeciwciał przeciwtarczycowych. U prawie wszystkich pacjentów stwierdza się podwyższony poziom przeciwciał przeciwko peroksydazie tarczycowej oraz tyreoglobulinie, dlatego badanie poziomu przeciwciał stanowi podstawę szybkiej i trafnej diagnozy. Pomocne
w rozpoznaniu jest również badanie płynu mózgowo-rdzeniowego oraz badanie elektroencefalograficzne. Leczeniem z wyboru jest przewlekła sterydoterapia, natomiast w przypadku braku poprawy lub steroidooporności stosuje się inne metody, takie jak plazmafereza, immunoglobuliny, immunosupresja czy leczenie biologiczne. W przypadku postawienia szybkiej i trafnej diagnozy oraz włączenia odpowiedniego leczenia, rokowanie jest dobre.
Concomitance of psoriasis with systemic metabolic diseases – an interdisciplinary problem
Authors: GRABAREK BENIAMIN , MICHALSKA-BAŃKOWSKA ANNA , KRZACZYŃSKI JAKUB , WCISŁO-DZIADECKA DOMINIKA
Published: January 2020

Wstęp

Celem niniejszej pracy była ocena częstości współwystępowania łuszczycy z cukrzycą, nadciśnieniem tętniczym i zespołem metabolicznym. Zamiarem autorów jest zwrócenie uwagi lekarzy rodzinnych na złożony obraz kliniczny łuszczycy, implikacje ze schorzeniami internistycznymi, a tym samym konieczność objęcia chorych opieką interdyscyplinarną.

Materiał i metody

Ankietę dotyczącą częstości występowania metabolicznych układowych chorób współistniejących z łuszczycą przeprowadzono w grupie 32 pacjentów z rozpoznaną łuszczycą zwykłą (20 mężczyzn i 12 kobiet). Charakterystyka grupy badanej przedstawia się następująco (średnia ± odchylenie standardowe): wiek 53,9 ± 10,4 roku, wzrost 169,9 ± 1,5 cm, masa ciała 88,8 ± 21,5 kg, BMI 30,65 ± 6,18, obwód talii 108,34 ± 17,14 cm.

Wyniki

Spośród 32 pacjentów z łuszczycą zespół X i nadciśnienie stwierdzono u 15, cukrzycę u 7, cukrzycę i zespół metaboliczny u 9, nadciśnienie tętnicze i zespół metaboliczny u 9, nadciśnienie tętnicze i cukrzycę u 6, natomiast współwystępowanie cukrzycy, zespołu metabolicznego i nadciśnienia tętniczego u 14 chorych.

Wnioski

Pacjenci z łuszczycą powinni zostać objęci interdyscyplinarną, kompleksową opieką specjalistyczną ze względu na podwyższone ryzyko współwystępowania schorzeń układowych. Współwystępowanie w tej grupie internistycznych chorób ogólnoustrojowych nasila istniejący stan zapalny. Lekarz pierwszego kontaktu odgrywa główną rolę w całym procesie diagnostyczno-terapeutycznym łuszczycy. Niezbędne jest lepsze zrozumienie złożonych patomechanizmów leżących u podstaw tej dermatozy, co stanowi klucz do skutecznej i bezpiecznej farmakoterapii.
Comorbidities in multiple sclerosis
Authors: Hercuń Emilia , Tomaszewski Witold , Juryńczyk Jacek
Published: January 2020

Wstęp

Stwardnienie rozsiane jest przewlekłą, zapalną, demielinizacyjną chorobą ośrodkowego układu nerwowego,
w której dochodzi do wieloogniskowego uszkodzenia tkanki nerwowej.

Materiał i metody

W badaniu przeanalizowano dokumentację pacjentów hospitalizowanych z powodu stwardnienia rozsianego (130 osób) na Oddziale Neurologicznym Szpitala Wojewódzkiego im. Jana Pawła II w Bełchatowie w okresie od stycznia 2010 do maja 2018 r. Grupę kontrolną (177 osób) utworzono z pacjentów Poradni Medycyny Pracy Instytutu Zdrowia Medicall w Piotrkowie Trybunalskim, konsultowanych w 2018 r.

Wyniki

U 49,2% pacjentów z SM stwierdzono inne schorzenia. Największy wskaźnik współchorobowości występował w postaci pierwotnie postępującej, a najmniejszy w postaci rzutowo-remisyjnej. Najczęstszymi jednostkami chorobowymi wśród pacjentów z SM były: nadciśnienie tętnicze (23,8%), depresja (9,2%), łagodny rozrost gruczołu krokowego (7,7%), cukrzyca typu 2 (6,9%), dyskopatia kręgosłupa (5,4%), choroba nowotworowa w wywiadzie (3,8%), wśród tych chorych 2% stanowiły nowotwory złośliwe i 2% niezłośliwe, choroba niedokrwienna serca (3,1%), niedoczynność tarczycy (3,1%), łuszczyca (3,1%), astma oskrzelowa (3,1%), wrzodziejące zapalenie jelita grubego (3,1%). Istotnym problemem u chorych z SM była również hiperlipidemia, która występowała u 35% badanych, w zdecydowanej większości w postaci podwyższonych wartości cholesterolu całkowitego i LDL.

Wnioski

Najczęstszymi chorobami współistniejącymi u pacjentów z SM są hiperlipidemia, nadciśnienie tętnicze, depresja, łagodny rozrost gruczołu krokowego, cukrzyca typu 2 i dyskopatia kręgosłupa. Rozkład częstości ich występowania różnił się w poszczególnych postaciach SM, co mogło wynikać z różnic wiekowych pomiędzy chorymi. Badanie kwestii współchorobowości u pacjentów z SM może poprawić efektywność leczenia tej grupy chorych i stanowi istotny element opieki koordynowanej.
Colon cancer – new strategies of treatment
Authors: Międzybrodzka Anna , Gmyrek Joanna , Cieślar Grzegorz , Kawczyk-Krupka Aleksandra
Published: January 2020

Rak jelita grubego jest jedną z najczęstszych przyczyn zgonów na świecie. Pomimo łatwo dostępnych narzędzi diagnostycznych nadal często rozpoznawany jest w stadium zaawansowanym, kiedy niejednokrotnie nie ma już możliwości leczenia radykalnego i pozostaje jedynie terapia paliatywna. Odrębnym problemem jest wznowa nowotworu, pogarszająca rokowanie pacjenta. Współcześnie poszukuje się nowoczesnych, wielokierunkowych metod leczniczych, które pozwoliłyby zahamować proces nowotworzenia, wydłużyć życie chorych i poprawić jego jakość. Obiecującym kierunkiem badań okazują się immunoterapia oraz terapia fotodynamiczna, które dają pomyślne wyniki również w zaawansowanych stadiach raka. Terapia fotodynamiczna wykazuje działanie przeciwnowotworowe poprzez efekt cytotoksyczny oraz immunomodulujący. Zastosowanie przeciwciał monoklonalnych w celowanej terapii raka jelita grubego jest nową, dobrze rokującą koncepcją wymagającą dalszych badań.