bluuebunny/crossref_metadata_2025 huggingface dataset:
AKTIVITAS ANTIDIABETES DARI KOMBINASI SERBUK IKAN GABUS (Channa striata) DAN EKSTRAK ETANOL KULIT BUAH RAMBUTAN (Nephelium lappaceum) PADA TIKUS PUTIH JANTAN GALUR WISTAR
Authors: Muhtadi Muhtadi , Faroska Amalinda Ayu , Suhendi Andi , Sutrisna EM.
Published: July 2019

Ekstrak etanol kulit buah rambutan (Nephelium lappaceum) dan ikan gabus (Channa striata)telah dilaporkan memiliki aktivitas antidiabetes secara in vivo. Tujuan dari penelitian ini untukmengetahui apakah kombinasi dari kedua ekstrak tersebut memiliki aktivitas antidiabetes yanglebih tinggi dibandingkan sediaan tunggalnya. Desain penelitian ini menggunakan metode preand post-test with control group. Penelitian ini menggunakan 15 tikus yang diinduksi aloksan150 mg/KgBB secara intraperitoneal, yang dikelompokkan menjadi 5 kelompok perlakuan, yaitukontrol negatif, kontrol positif glibenklamid 5 mg/KgBB, serbuk ikan gabus (SIG) 300 mg/KgBB,ekstrak kulit buah rambutan (EKBR) 300 mg/KgBB dan ekstrak kombinasi perbandingan 1:1. Setiapperlakuan diberikan secara oral setiap hari hingga 10 hari pengamatan. Ekstrak kombinasi mampumenurunkan 55,6% kadar glukosa darah. Serbuk tunggal ikan gabus dan ekstrak tunggal kulitbuah rambutan menurunkan glukosa darah berturut-turut 27,4% dan 71,2%. Berdasarkan analisisstatitistik, tidak ada perbedaan signifikan (p>0,05) antara ekstrak kombinasi terhadap perlakuantunggal SIG atau EKBR. Aktivitas kombinasi ekstrak memiliki kemampuan menurunkan kadargula darah yang lebih tinggi dibandingkan serbuk ikan gabus, tetapi lebih rendah dibandingkandengan ekstrak kulit buah rambutan.
CEMARAN BORAKS PADA CILOK YANG DIJUAL DI LINGKUNGAN SEKOLAH DASAR
Authors: Handayani Sri , Agustina Nur Wulan
Published: July 2019

Makanan jajanan merupakan bagian yang tidak terpisahkan dari kehidupan masyarakat.Makanan jajanan mempunyai peranan yang sangat penting bagi anak sekolah apabila disajikandalam kondisi higienis. makanan jajanan yang tedapat cemaran biologis maupun kimiawi dapatmenimbulkan keracunan, gangguan kesehatan bahkan kejadian luar biasa (KLB). Penyebab KLBkeracunan pangan di Indonesia berasal dari masakan rumah tangga (27,38%), pangan jasa boga(16,67%), pangan olahan (14,38%), pangan jajanan (16,67%) dan tidak diketahui sumber penyebabnya(4,17%). Kondisi tersebut apabila tidak diatasi dapat membahayakan anak sekolah. Tujuan penelitianini adalah melakukan identifikasi cemaran boraks pada cilok serta melakukan analisis faktor yangmempengaruhi. Sampling dilakukan secara purpusive sampling dengan sampel sebanyak 20. Metodepengumpulan data dengan wawancara pemeriksaan laboratorium untuk mengetahui cemaranboraks. Pemeriksaan laboratorium dengan menggunakan metode nyala api. Data yang diperolehdianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa terdapat 20% sampel yang positifmengandung boraks. Lama simpan cilok berkisar antara 1-3 hari.
AKTIVITAS SITOTOKSIK EKSTRAK DAUN SIRSAK (Annona mucirata L.) TERHADAP SEL KANKER SERVIK
Authors: Maritha Vevi , Ariyanti Ariyanti , Masruriati Eni , Sulistianingsih Eka Nur
Published: July 2019

Saat ini terapi kanker servik secara umum masih menggunakan kemoterapi. Penggunaan obat-obat seperti doxorubisin, vincristin dan 5 flourourasil yang bekerja dengan menghambat sel yang pertumbuhannya cepat. Obat ini memiliki kekurangan dimana tidak bersifat selektif, sehingga tidak hanya sel kanker saja yang dihambat tetapi sel normal yang pertumbuhannya cepat juga ikut terhambat seperti rambut dan kuku. Oleh karena itu perlu adanya suatu pengembangan obat kanker servik yang selektif, yang hanya menghambat pertumbuhan sel kanker sehingga tidak mengganggu sel normal. Potensi daun sirsak sebagai zat sitotoksik cukup tinggi. Daun sirsak memiliki aktivitas antioksidan mampu menghambat percepatan pertumbuhan pada sel kanker. Pada daun sirsak  mengandung acetogenin yang lebih tinggi dari pada bagian lain. Asetogenin mampu menghambat dan membunuh sel kanker secara selektif, yaitu hanya menghambat pertumbuhan sel kanker tanpa menghambat sel normal. Kandungan antioksidan dan acetogenin yang tinggi pada daun sirsak berpotensi untuk dikembangkan menjadi ekstrak sebagai zat sitotoksik terhadap sel kanker servik yang bekerja secara selektif.

Uji aktivitas sitotoksik daun sirsak dilakukan dengan metode MTT. Daun sirsak diekstrak dengan metode maserasi menggunakan pelarut etanol 96%. Kultur sel kanker servik (sel HeLa) di ditransfer sebanyak 1x104 sel/sumuran dalam media kultur lengkap yang terdiri dari FBS sebagai nutrisi utama sel, penisilin-sterptomisin sebagai pencegah kontaminan. bakteri, amfoterizin-B sebagai pencegah kontaminan jamur dan RPMI 1640 sebagai media pembawa (volume masing-masing sumuran 100 μl) kedalam 96-well plate dan diinkubasi dalam inkubator CO25% semalam. Selanjutnya dilakukan pemberian sampel uji dengan seri kadar dan dibuat replikasi tiga kali (triplo), kemudian diinkubasikan kembali semalam. Pengujian hari ke tiga, penambahan reagen MTT, dan setelah 4 jam akan terbentuk kristal formazan pada sel yang masih hidup. Selanjutnya ditambahkan SDS stoper untuk menghentikan reaksi MTT. Kemudian dilakukan pembacaan absorbansi menggunakan elisa reader pada panjang gelombang 595nm. Selanjutnya bersama dengan data kadar sampel yang digunakan dilanjutkan penentuan nilai IC50. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak memiliki potensi terhadap sel kanker servik dengan nilai IC 50 sebesar 337 µg/µL. Ekstrak daun sirsak dapat dikembangkan sebagai alternative terapi bagi pasien kanker serviks.
ORTHOPEDIC TREATMENT OF PATIENTS WITH EDENTULOUS JAWS WITH COMPLETE REMOVABLE PLASTIC DENTURES USING ADHESIVE MATERIAL
Authors: Movchan O.V.
Published: July 2019

The article reflects that one of the topical problems of orthopedic dentistry is an increase in the functional efficiency of removable dentures and prevention of atrophic changes in the supporting tissues of the prosthetic area by improving the methods of manufacturing prostheses. The solution to this problem is directly dependent on the specific clinical conditions. Under the above clinical conditions of the prosthetic area, the basis of the prosthesis should be differentiated, that is, the corresponding layer of adhesive material must restore the damping properties of the thin mucosal layer with low compliance, the prerequisite being the unloading of zones predisposed to atrophic processes and the load of sites resistant to atrophy.

In the process of adapting patients to prostheses using the adhesive material for up to 3 days, as well as for measuring the values of the chewing pressure and chewing efficiency, the patient did not complain of pain or discomfort.
Cerdas Tanggap dalam Pencegahan Anemia di SMAN 1 Rumbio Jaya Tapung
Authors: Yusmaharani Yusmaharani
Published: June 2019

ABSTRACT

 

Anemia is a condition where the hemoglobin (Hb) level in the blood is less than normal. Young women have ten times greater risk of anemia. Anemia can cause fatigue, learning concentration decreases so learning achievement is low, if not handled properly it will continue into adulthood and can increase maternal and infant mortality. The purpose of this community service is to train female students to avoid anemia which can endanger women's reproductive health, especially during pregnancy. Community service was carried out on Maret 1and 16  2018. The method in this service at the first meeting conducted counseling and training on how to deal with anemia, as well as HB examinations to participants. At the second meeting with an interval of 1 week an evaluation of how to treat anemia and Hb examination was conducted. The results of this activity are 99% of students able to repeat how to properly manage healthy eating patterns, and 100% of students who have anemia are no longer anemic. Anemia is still a health problem in Indonesia, this anemia can be caused by the habit of frequently consuming less nutritious foods. Prevention of anemia by regulating diet and a healthy lifestyle is very helpful to overcome anemia. The faster the precaution is taken, the anemia will not worsen the health condition of adolescents in the future.

 

Keywords: Response, Prevent, Anemia

 

ABSTRAK

 

Anemia adalah suatu keadaan dimana kadar hemoglobin (Hb) dalam darah kurang dari normal. Remaja putri memiliki risiko sepuluh kali lebih besar untuk menderita anemia. Anemia dapat menyebabkan lekas lelah, konsentrasi belajar menurun sehingga prestasi belajar rendah, jika tidak ditangani dengan baik akan berlanjut hingga dewasa dan dapat meningkatkan angka kematian ibu, dan bayi. Tujuan dari pengabdian masyarakat ini untuk melatih siswi agar terhindar dari anemia yang dapat membahayakan kesehatan reproduksi wanita, khususnya saat kehamilan. Pengabdian masyarakat ini dilakukan pada tanggal 1 dan 16 Maret 2018. Metode dalam pengabdian ini pada pertemuan pertama melakukan penyuluhan dan pelatihan cara mengatasi anemia, serta pemeriksaan HB kepada peserta. Pada pertemuan kedua dengan selang waktu 1 minggu dilakukan evaluasi cara mengatasi anemia dan pemeriksaan Hb. Hasil dari kegiatan ini adalh 99% siswa mampu mengulangi cara mengatur pola makan yang sehat dengan benar, dan 100% siswa yang mengalami anemia sudah tidak mengalami anemia lagi. Anemia masih menjadi masalah kesehatan di Indonesia, anemia ini dapat disebabkan oleh kebiasaan sering mengkonsumsi makanan yang kurang bergizi. Pencegahan anemia dengan cara pengaturan pola makan dan pola hidup sehat sangat membantu mengatasi anemia. Semakin cepat tindakan pencegahan dilakukan maka anemia tidak akan  memperburuk kondisi kesehatan remaja dimasa yang akan datang.

 

Kata Kunci: Tanggap, Cegah, Anemia
Pelatihan Pemberdayaan Istri Nelayan Melalui Pelatihan Digital Marketing Strategy (DMS) Darah Biru
Authors: Azizah Nisaul
Published: June 2019

Abstract

               The fisherman’s wife was one of the nonproductive community that couldn’t get salary by themselves. The horseshoe crab was the most crab that live in Mayangan’s village. Usually, the community eat this crab and throw the blood away. In fact, this blood, blue colored, has many advantages in pharmacy area that one of ingredient to produce the medicines. The training was needed by community to produce and market the blue blood using digital marketing strategy. The training method covers the formation of caders, the packaging product, creating e-commerce account, the marketing strategy, finacial bookkeeping, and evaluating the use of digital marketing strategy. The training objects were five fisherman’s wives who live in Mayangan Villege and couldn’t earn the salary. After the training held, the community has computer skill and e-commerce account to promote the blood. They also could package the blood that must have good quality in several days. They also were skilled in financial bookkeeping and manage the e-commerce account. Finally, this community could earn the salary by themselves using the production and digital marketing strategy.

 

Keywords—training, digital marketing strategy, blue blood

 

 

Abstrak

Istri nelayan merupakan salah satu masyarakat nonproduktif ditinjau dari kemandirian dalam mendapatkan penghasilan. Darah biru merupakan salah satu komponen pada kepiting tapal kuda yang sangat melimpah di Desa Mayangan. Biasanya, kepiting diolah sebagai masakan dengan proses pembuangan darah biru. Darah biru merupakan salah satu bahan baku obat sehingga diperlukan di bidang farmasi. Pemanfaatan darah biru ini perlu diberikan kepada mitra dan dipasarkan sehingga dapat memberikan penghasilan bagi istri nelayan. Kegiatan pelatihan ini bertujuan untuk memberdayakan istri nelayan agar menjadi masyarakat mandiri dengan memproduksi ekstrak darah biru dan memasarkannya melalui sarana digital. Metode pelaksanaan pelatihan diawali dari sosialisasi, pembentukan kader, strategi pengemasan produk, pembuatan akun e-commerce, strategi pemasaran, strategi pembukuan keuangan, dan evaluasi pemasaran digital. Sasaran pelatihan yaitu lima orang istri nelayan di Desa Mayangan yang tidak mempunyai pekerjaan. Hasil kegiatan ini yaitu adanya kemandirian masyarakat yang ditinjau dari adanya penghasilan yang diperoleh melalui strategi pemasaran darah biru. Penggunaan e-commerce sebagai sarana pemasaran digital dikelola dengan baik sehingga mampu menambah skill mitra di bidang komputasi. Mitra telah mempunyai pembukuan keuangan. Pengkaderan yang dilakukan bertujuan untuk keberlangsungan produksi dan pemasaran darah biru.

 

Kata kunci—pelatihan, digital marketing strategy, darah biru
WORKSHOP MOBILE LEARNING MENUJU SEKOLAH BERBASIS DIGITAL PADA SMK NEGERI 1 SIAK KECIL
Authors: Yoyon Yoyonefendi , Lusi Lusiana , Romet Rometdo Muzawi
Published: June 2019

Abstract

               Digital school is a school concept that utilizes the development of information technology in its management. The digital school discusses various aspects such as review, administration, grades, counseling (BK) and others. To get to the school, learning media such as Mobile Learning are needed. The Mobile Learning Workshop which was attended by 40 people consisted of students, teachers and school employees. During this Workshop, participants were given material about digital schools, Mobile Learning, IoT and mobile Applications. In the practical session participants create a mobile application using the online-based inventor2 application. The mobile application is made like the application of a school activity schedule. The purpose of this workshop is to increase knowledge and expertise in the mobile field.

 

Keywords— Mobile Learning, Digital School, SMK N 1 Siak Kecil

 

 

Abstrak

Sekolah digital merupakan sebuah konsep sekolah yang memanfatkan perkembangan teknologi informasi dalam pengelolaannya. Sekolah digital meliputi berbagai aspek seperti pengajaran, administrasi, nilai, Bimbingan konseling (BK) dan lainnya. Untuk menuju sekolah tersebut dibutuhkan media Learning seperti Mobile Learning. Workshop Mobile Learning yang diikuti 40 orang terdiri dari siswa, guru dan pegawai sekolah. Selama Workshop ini, peserta diberikan materi tentang sekolah digital, Mobile Learning, IOT dan Aplikasi mobile. Pada sesi pratikum peserta mendapatkan pembuatan aplikasi mobile menggunakan app inventor2 berbasis online. Aplikasi mobile yang dibuat seperti aplikasi jadwal kegiatan sekolah. Tujuan Workshop ini dapat menambah pengetahuan dan keahliaan pada bidang mobile Learning yang dapat meningkat mutu belajar mengajar disekolah.

 

Kata kunci— Mobile Learning, Sekolah Digital, SMK N 1 Siak Kecil
Jurnal Pengabdian Masyarakat
Authors: Septiani Pipit Eka
Published: June 2019

Abstrak

Desa Bendar adalah wilayah pesisir di Kecamatan Juwana Kota Pati, sehingga para masyarakat didominasi oleh mata pencaharian sebagai nelayan. Para nelayan berlayar selama 50 mil jauhnya dalam jangka waktu selama kurang lebih 1-3 bulan, kemudian pulang ke daratan membawa hasil tangkapan untuk dilelang di Tempat Pelelangan Ikan (TPI). Istri nelayan yang ditinggal selama 3 bulan mengalami kendala dalam memenuhi kebutuhan hidupnya, sehingga perekonomian keluarga di Desa Bendar menjadi tidak stabil. Oleh karena itu, melalui kegiatan PKM (Program Kreativitas Mahasiswa) ini, kami membentuk sebuah mitra usaha yang beranggotakan 6 orang untuk para istri nelayan yang bertujuan untuk memenuhi kebutuhan hidupnya selama ditinggal berlayar, guna meningkatkan perekonomian keluarga Desa Bendar melalui produksi kerupuk cumi. Kegiatan PKM  ini, dimulai dengan koordinasi mitra, Konsultasi dengan Pihak Mitra Desa Bendar, koordinasi dengan anggota mitra, dilanjutkan dengan sosialisasi dan pelatihan produksi kerupuk cumi. Hasil dari kegiatan ini, adalah terbentuknya mitra produksi yang memproduksi kerupuk cumi beserta pemasarannya. Selain itu, produk imi akan diangkat sebagai oleh-oleh khas Desa Bendar, Kampung Nelayan.
The development of the technical concept of the tractor
Authors: Kut'kov G. M
Published: July 2019

The development of the technical concept of an agricultural wheeled tractor is analyzed depending on the continuous growth of its energy saturation, as an indispensable factor in raising the technical level. The technological properties and methods of aggregating tractors of three generations of energy saturation called traction, traction energy and energy concepts, are considered. At present, in the world tractor construction, tractors of the traction concept are almost out of production; tractors of power traction and, to a lesser extent, energy concepts, are mainly produced. Tractors of the second generation differ from tractors of the first generation that they include ballast in a factory complete set. Ballasting has become a necessary way to artificially increase the weight of the tractor and reduce its energy saturation due to the limitation of the speed of technological operations, introduced by the rules of agricultural engineering. It is assumed that in the foreseeable future this restriction will not be removed. Even now, ballasting as a way to compensate for the weight loss of the tractor has almost exhausted its possibilities, because ballast weights reach half of the tractor weight and more. As the tractor continues to increase its energy saturation and maintains limitations on the speed of technological operations, the ballasting will require replacement. The article proposes instead of ballasting the use of a third movable axle and a block-modular aggregation system, as well as the use of electric transmission on the third-generation tractors and an active drive to the motor-wheel of agricultural machinery. It is shown that the second generation tractors have potential technological properties that can be implemented under the condition of competent and easy to operate maneuvering level of ballasting. In general, the use of tractors of the second and third generations of traction energy and energy concepts will significantly reduce: the material intensity of machine tractor unit; fuel consumption; the harmful effects of tractor propellers on the soil, variability (the difference of tractors in terms of the nominal tractive force on the hook) of tractors in the economy.
System studies of the preparation of protein feed
Authors: Priporov I. E
Published: July 2019

The purpose of the study is to determine the direction of development of system studies of the prepa-ration of protein feed. System analysis of the preparation of protein feed is carried out by dividing the sys-tem into subsystems of different levels (process lines) and elements (technical devices), which will allow to outline the stages of research and to construct their classification. In the scientific systems theory, we will follow the path of «exact technology of animal husbandry», which was considered by academician Leonid Kormanovsky, built on the basis of mathematical models obtained as a result of theoretical studies (analysis) and experimentally (empirically). In turn, the "exact technology of animal husbandry" should be based on the technical systems of the mathematical model and specific technical developments of devices and technologies for the preparation of protein feed. For the preparation of protein feed in the free running and granular types in order to reduce the energy intensity of the process and improve its quality, the line for its implementation under patent No. 2646092 and the method according to patent No. 2636480 were developed. The design and technological process of its work are given. A system for the preparation of protein feed was developed on the basis of the general theory of systems. The analysis in this area showed the absence of systemic studies on the preparation of protein feed based on the general theory of the system as applied to «accurate technology of animal husbandry», namely, in «accurate technology of preparation of protein feed» using a multimedia device that controls the process. Therefore, it is necessary to develop a mathematical model based on the theory of the general system with respect to the exact technology of preparation of protein feed. The developed mathematical model allowed to increase the nutritional value of protein feed, as well as to expand their range for feeding cattle, namely for each species of agricultural animal with its physiological peculiarity and need for them, and to improve the environment ecology.
A FINITE-ELEMENT METHODOLOGY OF ANALYZING A 3D PROBLEM OF DYNAMICS OF STRUCTURES STIFFENED BY A SYSTEM OF REINFORCING RODS
Authors: Ivanov V. A. , Kibets A. I. , Kibets Yu. I.
Published: July 2019

Nonstationary deformation of spatial structures made of piecewise-homogeneous isotropic materials (matrices), stiffened by a discrete system of curvilinear rods sustaining effects of tension-compression, is considered. It is assumed that the number of reinforcing rods is not large and their arrangement in the main material can be irregular.
In analyzing such structures, the averaging methods used in mechanics of composite materials may become inapplicable. The defining equation set is formulated in Lagrange variables. Equations of motion are derived from the virtual work power balance. Kinematic relations are defined in the metrics of a current state. Relations of Beton's yield theory are used as equations of state for metals and alloys, and masonry is considered as a hetero-modular medium, the equations of state of which depend on the type of stressed-strained state and damage degree. The problem is analyzed using a momentary scheme of the finite element method and a cross-type explicit finite-difference time integration scheme. The analyzed region is discretized using 8-node finite elements with a poly-linear approximation of displacement velocities. The curvilinear, in a general case, reinforcing rods are discretized into straight sections, the spatial location of which is defined by the coordinates of the points of their intersection with the sides of the finite elements of the mesh of the main material. Slipping between the reinforcement and the binding material is not considered. Stresses in the rod are substituted for by statically equivalent forces of the nodes of the finite element of the matrix, which are projected onto a common coordinate system and summed with node forces from stresses in the main material and external loading. To verify the developed finite-element methodology, a number of benchmark problems have been analyzed.
A RAPIDLY ERECTED TEMPORARY STRUCTURE PROTECTING FROM POWERFUL EXPLOSIONS
Authors: Аbakumov A. I. , Bazarov Yu. B. , Veselova E. A. , Vyalykh A. M. , Gubachev A. V. , Lobastov S. A. , Safronov I. I. , Tsypkin V. I. , Smirnov A. S.
Published: July 2019

A design of a rapidly erected temporary structure reducing adverse factors of a powerful explosion to the levels safe both for people and building structures is proposed. The protective structure consists of three separate metal frames with the open upper part, welded or bolted to each other and covered with metal profile. Each frame houses reservoirs of watertight cloth filled with water.
Damping of an air shockwave has been numerically modeled, and a full-scale rapidly erected temporary protective structure has been tested with an explosion of a home-made 100kg-trotil equivalent explosive device installed in a car.
The explosion process and its impact on the protective structure were numerically modeled in a hydrodynamic formulation, where the structure prior to the beginning of failure was regarded as a rigid non-deformable body. According to the computational results, a rectangular geometry of the frame is more effective than a trapezoidal one.
The parameters of the air shockwave were measured with SPK-sensors according to the certified and registered in the State Register methodology “SVР20-VUV” providing measurement of pressure amplitudes to the accuracy of not more than ±11 %.
The numerical results are compared with the results of tests of the proposed design of a protective structure. The numerical and experimental data on the peak value of pressure without the protective structure satisfactorily agree Sadovskiy's formula for a ground explosion. Times of arrival of the air shockwave and maximal pressures along its front in the control points in front of and behind the protective structure obtained numerically and experimentally agree within measuring accuracy.
HUBUNGAN PENGETAHUAN DAN PERILAKU MEROKOK ANGGOTA KELUARGA DENGAN KEJADIAN ISPA DI DESA BASAAN 1 WILAYAH KERJA PUSKESMAS KECAMATAN RATATOTOK
Authors: Karundeng Yanni , Runtu Lorrien G , Mokoginta Tirsa
Published: July 2019

Penyakit ISPA (Infeksi Saluran Pernapasan Akut) merupakan salah satu penyakit infeksi yang menular pada pernapasan dan merupakan penyakit infeksi yang masih menjadi isu kesehatan global disemuah Negara. Berdasarkan hasil (Riskesdas, 2013) Infeksi saluran pernapasan akut disebabkan oleh virus atau bakteri, diawali dengan panas disertai salah satu atau lebih gejala : tenggorokan sakit/nyeri menelan, pilek batuk kering atau berdahak. Tujuan penelitian ini untuk menganalisis hubungan pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA di Desa Basaan 1 wilayah kerja Puskesmas Kecamatan Ratatotok Jenis penelitian ini adalah analitik dengan pendekatan Cross sectional yaitu menganalisis hubungan pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA di Desa Basaan 1 wilayah kerja Puskesmas Kecamatan Ratatatotok sebanyak 91 responden yang menjadi subjek sesuai dengan kriteria inklusi. Uji statistic dengan Chi Square dengan tingkat kemaknaan = 0,05 Hasil penelitian menunjukan ada hubungan antara pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA diperoleh = 0,05 p value 0,009 sedangkan perilaku merokok anggota keluarga diperoleh hasil = 0,05 p value 0,05 artinya ada hubungan dengn kejadian ISPA  Kesimpulan hasil penelitian membuktikan bahwa ada hubungn antara pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA.
conventional educational with indoor & outdoor modules on disaster preparedness in high school students in Tomohon
Authors: Rondonuwu Rolly Harvie Stevan , Tandiayuk Monica , Sarimin Dorce Sisfiani
Published: July 2019

Indonesia is one of the countries that experiences quite a lot of natural disasters such as floods, landslides, earthquakes, volcanic eruptions, tsunamis. Increased volcanic volcanic activity in Indonesia's volcanoes allows for potential eruptions in several regions. Disasters that occur in the community require good handling based on targeted disaster management, given that disasters come unexpectedly, for that many things must be prepared carefully including educational interventions on disaster management. This study aims to determine the differences using conventional indoor modules and modules indoor & outdoor on volcanic disaster preparedness in high school students in the city of Tomohon, North Sulawesi.The research design in this study was Quasi experiment one group pre-post-test. In this design high school students were given a pretest before being given education to find out the initial condition, and posttest after being given education, then it would be known whether there was a difference between the scores pretest and posttest . The population in this study were all Lokon high school students, and the sample was 10th grade students totaling 60 people, held in September 2016.The results showed that the experimental group student learning outcomes were better than the control group. The average posttest value of the experimental group students (73.27) was higher than the mean value of the control group posttest (66.17). thus there are differences in scores in the group given the indoor module intervention with the indoor-outdoor module intervention group with a value of p 0.001. (t independent test)Based on the results of the study concluded that there are differences in knowledge between students who are taught using the method indoor learning with students who use methods indoor & outdoor learning. Suggestion: expected teaching methods indoor + outdoor can be developed as a variety of learning methods Keywords: conventional Education, indoor & outdoor modules, Disaster
FAVORABLE IMPACTS OF A FRAGMENT OF ATLANTIC FOREST ON WATER QUALITY IN AN URBAN RIVER IN NORTHEASTERN BRAZIL
Authors: Silva João Carlos de Miranda e , Costa Dimítri de Araújo , Christoffersen Martin Lindsey
Published: July 2019

The Jaguaribe river is entirely urban in its extent. It follows a convoluted course through the city of João Pessoa, the capital of the State of Paraíba. As with other urban water bodies in Brazil, the quality of its water is compromised by diffuse contaminations arising from a diverse array of poluting souces originating from diverse localities along its course. On the basis of hydric monitoring, accomplishede by the Superintendência de Administração do Meio Ambiente (SUDEMA), it was possible to infer that water quality is best in the stretch contained within the area of environmental preservation “Mata do Buraquinho”, today named Botanic Garden Benjamin Maranhão. This ecosystem, located in the central region of João Pessoa, provides several environmental services to the population living in this city, such as climatic regulation, genetic resources, biodiversity, recreation, and ecotourism, among others. It also produces positive impacts on the water quality of the river flowing through this preservation area. Data from chemical analyses were listed as temporal series (2006 to 2016), making it possible to compare two water sampling stations (JB01 e JB02). Alterations were recorded for some parameters, such as water color, turbidity, number of heat-toletant  coliforms, and increase in dissolved water oxigen.
PHYSIOTHERAPEUTIC INTERVENTION IN PATIENTS AFFECTED BY THE SYNDROME OF SPOAN: AN EXPERIENCE REPORT
Authors: Queiroz Neila Alves de , Monteiro Rosemary Araújo , Bezerra Marylia Paula , Christoffersen Martin Lindsey
Published: July 2019

The SPOAN syndrome is a neurodegenerative disease of autosomal recessive inheritance that causes atrophy of muscles of the upper and lower limbs of the affected individuals. The disease had its initial characterization carried out in individuals originating in the upper western part of the city of Serrinha dos Pintos, State of Rio Grande do Norte, by researchers from the Center for Human Genome Studies and Hospital das Clínicas of the University of São Paulo in the year 2005. Its clinical characteristics include: congenital and atrophic optic atrophy Progressive spastic paraplegia, with early onset of life, axonal neuropathy, with clinical onset after the first decade of life, startle response with unexpected sounds, dysarthria, spinal and foot deformities, and extrapyramidal signs. The present text aims to report the cases of patients with SPOAN under the physiotherapeutic assistance of the Expanded Nucleus of Family Health (NASF) in the city of Serrinha dos Pintos-RN. Experience report: This is an experience report on the care of patients with SPOAN syndrome assisted by the municipality's NASF. In the municipality there were 14 patients with SPOAN, but only 4 (28.5%) of these patients attended the physiotherapeutic care. The treatment lasted an average of 40-50 minutes, with moderate resting pauses between sessions. They consisted of: passive joint mobilization exercises, scapular and pelvic girdle dissociation exercises, intra-articular mobilization exercises, stretching, muscle strengthening , respiratory exercises, myofascial release, Kabat methods, Bobath and Pilates, electrotherapy, and auriculotherapy. Final considerations: Physiotherapic care given to patients with SPOAN syndrome is considered to be extremely important for the preservation of functionality of these patients, since there is a satisfactory clinical evolution, with improvement of muscular strength and flexibility, range of joint movement and respiratory capacity. Therefore, future studies regarding the diagnosis and prognosis of SPOAN are necessary, since early appropriate therapeutic intervention allows the best functional outcome.
Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways
Authors: Syvyk A.E. , Syvyk T.L.
Published: July 2019

Summary. Aim: The ERBB2 receptors tyrosine kinase, also known as HER2/Neu, play an essential role in early organism development and modulation of cell behavior in varieties of tissue in an adult organism. Our aim was the generation of transgenic rat spermatogonial line capable of inducible expression of a dominant negative form of the ERBB2 protein in vitro and the transgenic rat as an animal model for dissection of the ERBB2 mediated signaling in vitro and in vivo. Materials and Methods: Donor derived rat spermatogonial stem cells that express green fluorescence protein and inducible ERT2CreERT2 recombinase were modified with Sleeping Beauty transposon-based vector that express truncated kinase deficient form of the ERBB2 receptor upon Cre mediated recombination. Clonally selected spermatogonial cell lines were extensively tested in vitro. Animals were generated via spermatogonia mediated transgenesis by transplantation of clonal cell line into testes of chemically sterilized recipients. Obtained progeny were tested for inducibility in vivo and served as donors of spermatogonia for downstream analysis. Results: We obtained animals and clonally derived spermatogonial stem cell lines that express an inducible dominant negative form of the ERBB2 protein. Isogenic nature of induced and uninduced cells allows most accurate morphological and molecular comparison of cells affected by the interruption of normal function of the ERBB2 receptor and cellular dynamics in vitro and in vivo. Conclusions: Clonally derived spermatogonial stem cell lines that express an inducible dominant negative form of ErbB2 demonstrated an obvious difference in morphological appearance and growth kinetics of induced cells comparing to uninduced ones. Western blot analysis of induced and uninduced cells revealed significant differences in presence and phosphorylation state of several tested important proteins involved in the ERBB2 mediated signal transduction, such as S6 ribosomal protein; AKT (the serine/threonine kinase also known as protein kinase B); and three protein kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade PRAS40, MEK, ERK1/2.
Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma
Authors: Kravets O.V. , Protsyk V.S. , Burtyn O.V. , Hlynin O.V. , Hurianov V.H.
Published: July 2019

Summary. The aim of the work was to study clinical and pathological factors affecting the prognosis of the disease in patients with stage III–IVA-B oral squamous cell carcinoma (OSCC). Materials and Methods: A retrospective review of medical records of 234 patients with stage III–IVA-B OSCC was performed in order to study the impact of clinical and pathological factors on disease-free survival (DFS) and overall survival (OS). Results: Multivariable analysis of clinical factors revealed a statistically significant effect of stage IVA-B and the presence of surgical complications on DFS (hazard ratio (HR) = 4.9 (95% confidence interval (CI) 2.9–8.3), p < 0.001; HR = 1.6 (95% CI 1.0–2.6), p = 0.047), respectively. Stage IVA-B, the presence of surgical complications and the retromolar trigone subsite were found to have a statistically significant impact on OS (HR = 4.0 (95% CI 2.5–6.5), p < 0.001; HR = 1.8 (95% CI 1.1–2.8), p = 0.01; HR = 1.9 (95% CI 1.1–3.2), p = 0.02), respectively. Multivariable analysis of pathological factors showed a statistically significant effect of positive resection margins, the multiple lymph node involvement and high-grade tumor on DFS (HR = 3.7 (95% CI 2.0–6.6), p < 0.001; HR = 4.3 (95% CI 2.8–6.7), p < 0.001; HR = 1.6 (95% CI 1.1–2.2), p = 0.01), respectively. Besides, positive resection margins and multiple lymph node involvement were found to cause a statistically significant impact on the OS (HR = 3.6 (95% CI 2.0–6.5), p < 0.001; HR = 3.7 (95% CI 2 5–5.6), p < 0.001), respectively. A tumor grade tended to worsen OS (HR = 1.4 (95% CI 1.0–1.9), p = 0.053). Conclusion: Stage IVA, B, the presence of surgical complications, the retromolar trigone subsite, positive resection margins, multiple lymph node involvements and high-grade tumor were found to be significant clinical and pathological prognostic factors in patients with stage III–IVA-B OSCC.
Prognostic factors in metastatic gastric carcinoma
Authors: Ben Kridis W. , Marrekchi G. , Mzali R. , Daoud J. , Khanfir A.
Published: July 2019

Summary. Although its incidence has declined over last half-century, gastric cancer remains the second most frequent cause of cancer death in the world. The ⅔ of the patients are metastatic at diagnosis. The current study aimed to identify some determinants of survival in patients with metastatic gastric carcinoma. Materials and Methods: It was a retrospective study that involved 49 patients treated with palliative chemotherapy between January 2000 and December 2010. Factors included: age, gender, performance status, metastatic diagnosis onset (at diagnosis or later); specific metastatic sites, number of metastatic localizations, response to chemotherapy, and hemoglobin rate. Results: In univariate analysis, factors associated to a better survival were: metastasis at diagnosis, good performance status, response to chemotherapy and single metastatic site. Independent factors in multivariate analysis were: metastasis at diagnosis and single metastatic site. Conclusion: Our study confirmed many determinants on survival described in the literature.
The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer
Authors: Dumanskiy Y.V. , Bondar O.V. , Stoliarchuk E.A.
Published: July 2019

Summary. Over the past decades, breast cancer (BC) is the most common cancer and one of the key causes of mortality and disability among women in developed countries. Aim: Determination of the role of Ki-67 index in assessing the quality of neoadjuvant polychemotherapy treatment using regional or systemic delivery routes of pharmacological agents in patients with locally advanced breast cancer (LABC). Materials and Methods: The retrospective analysis of 30 clinical trials of LABC treatment based on selective intra-arterial therapy in patients with BC (T4A-DN0-3M0) was used. Results: The decrease in Ki-67 level in LABC after selective intra-arterial polychemotherapy was more pronounced than after systemic polychemotherapy. No correlation of the tumor metastatic potential with a Ki-67 level was detected. Conclusion: Assessment of Ki-67 expression allows to evaluate effectively the biological properties of the tumor, predict the course of the disease and choose the optimal tactics of neoadjuvant polychemotherapy (regional or systemic variant) as part of integrated antitumor treatment.
The observation of congenital retroperitoneal large size neuroblastoma
Authors: Starchenko I.I. , Dyachenko L.V. , Prylutskyi О.K. , Vynnyk N.I. , Filenko B.M.
Published: July 2019

Summary. The article represents current literature data on epidemiological, clinical-morphological features and diagnostic criteria of neuroblastoma. The case of large congenital neuroblastoma with multiple metastases in the newborn child is presented. The histological picture and immunohistochemical profile of the tumor allowed us to consider this type of neuroblastoma as the least differentiated variant (subtype, “neuroblastoma rich in Schwann stroma”), with rapid progression and metastasizing started before the birth of the child.
INTERAKSI SIMBOLIK ANTARA ATASAN DAN BAWAHAN DI PT. IMSE MARINDO UTAMA GAS ENGINE JAKARTA
Authors: Yohana Angel , Saifulloh Muhammad
Published: June 2019

Kegiatan-kegiatan yang dilakukan oleh tiap individu dalam organisasi tentu melibatkan elemen-elemen komunikasi sosial yang menciptakan terjadinya interaksi sosial, dimana komunikasi adalah proses pembentukan makna melalui pesan, baik pesan verbal maupun pesan nonverbal yang berupa simbol-simbol, tanda-tanda, dan perilaku. Penelitian ini dilakukan bertujuan untuk mendapatkan gambaran tentang proses interaksi simbolik antara atasan dan bawahan di PT. IMSE Marindo Utama Gas Engine Jakarta dalam mengurangi terjadinya kesalahpahaman dalam komunikasi (miss communication). Pendekatan penelitian yang digunakan adalah kualitatif dengan metode studi kasus. Teknik pengumpulan data dilakukan melalui observasi dan wawancara. Dalam penelitian ini peneliti menggunakan teori interasi simbolik yang memiliki tiga konsep kunci utama; mind, self, society yang mana simbol-simbol sikap, perilaku, cara bicara, cara berpakaian terlihat dalam interaksi yang berlangsung. Dari hasil penelitian interaksi berlangsung secara harmonis, penelitian inipun menunjukan bahwa keterlibatan dalam suatu interaksi menimbulkan kedekatan hubungan antara atasan dan bawahan.
ADAPTASI BUDAYA MAHASISWA ASAL INDONESIA DI AUSTRALIA
Authors: Soemantri Nathalia Perdhani
Published: June 2019

Penelitian ini bertujuan untuk melihat proses adaptasi budaya mahasiswa asal Indonesia di Australia. Penelitian ini menggunakan pendekatan Fenomenologi dengan metode kualitatif deskriptif dengan menggunakan teknik pengumpulan data wawancara yang dilakukan pada dua orang pelajar asal Indonesia yang berkuliah di Australia. Sebagai pisau analisis, penulis menggunakan teori adaptasi budaya yang didalamnya terdapat proses, tahapan, dan faktor-faktor adaptasi budaya. Selain itu untuk melengkapi penelitian ini juga menggunakan teori Akomodasi yang didalamnya terdapat jenis-jenis dan asumsi dari akomodasi komunikasi. Hasil penelitian ini menunjukkan bahwa mahasiswa asal Indonesia yang berkuliah di Australia melakukan proses adaptasi yang terdiri dari adaptation dan growth. Sedangkan faktor-faktor adaptasi budaya yang ditemukan adalah enkulturasi, akulturasi, dekulturasi, dan asimilasi. Mahasiswa asal Indonesia juga melakukan akomodasi dengan mendasarkan pada pengalaman sehingga mereka dapat menyesuaikan diri dengan lawan bicara dan secara selektif melakukan konvergensi dalam berkomunikasi.
PEMASARAN MUSIK PADA ERA DIGITAL DIGITALISASI INDUSTRI MUSIK DALAM INDUSTRI 4.0 DI INDONESIA
Authors: Dewatara Gerry Wahyu , Agustin Sari Monik
Published: June 2019

Penelitian ini akan membahas bagaimana digitalisasi dalam industri musik mempunyai dampak pada pemasaran musik. Hal tersebut berdampak besar bagi para pelaku industri dalam hal pemasaran musik maupun konsumen dalam hal menikmati musik. Layanan streaming menjadi sesuatu yang sangat berpengaruh dalam era digital yang kita kenal industri 4.0. Industri musik tidak lagi dapat bergantung pada produk fisik dan konsumen pun kini lebih selektif dalam menikmati musik. .Metode yang digunakan pada penelitian ini adalah metode kualitatif dengan strategi penelitian fenomenologi tentang apa yang dialami oleh subjek penelitian, seperti; perilaku, persepsi,motivasi, tindakan, dan lain-lain secara holistik dan dengan cara deskripsi dalam bentuk kata-kata dan bahasa. Hasil penelitian ini adalah bagi konsumen  adalah mudahnya pencarian musikdan pelaku industri sangat mendukung adanya digitalisasi dalam industri musik karena mempermudah dalam memasarkan musik mereka dan membantu melindungi kekayaan intelektual mereka karena mengurangi pembajakan.
The Assessment of Red Blood Cell Distribution Width, Platelet Parameters and Inflammatory Markers in Patients on Antıpsoriasis Therapy
Authors: Kalaycı Osman Murat , Gülseren Duygu , Akan Tülin
Published: July 2019

Aims: Psoriasis is an inflammatory skin disease with several comorbidities. We aimed to evaluate red blood cell distribution width (RDW), platelet parameters and inflammatory markers in patients on antipsoriasis therapies.

Methods: 94 psoriasis patients and 74 healthy controls were prospectively analyzed. Before and after 8 weeks of different therapies (calcipotriol+clobetasol propionate; narrow-band UVB; combined narrow-band UVB and acitretin; infliximab and adalimumab), red blood cell distribution width (RDW), platelet parameters, high sensitivity C reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR) levels were measured. Lipid profile and fasting blood glucose tests were also performed prior the treatment. Psoriasis severity and area index (PASI) and body mass index (BMI) were calculated for each patient.

Results: RDW, hs-CRP, triglyceride, total cholesterol levels and BMI were higher in patients than in controls (p<0.05, for all four). No significant differences were observed in RDW, platelet parameters, hs-CRP and ESR levels after all therapies (p>0.05, for all). RDW was not correlated with PASI (p>0.05).

Conclusion: Psoriasis patients should be screened for dyslipidemia and obesity. Antipsoriasis therapies do not have any effect on inflammatory markers. Further studies are needed to elucidate the use of RDW and platelet parameters as an inflammatory marker in psoriasis.
EFISIENSI PEMANFAATAN PRODUK SPIDER ART (SENI SERBUK KOPI EFISIENSI PEMANFAATAN PRODUK SPIDER ART DAN SERBUK GERGAJI) SEBAGI MEDIA LUKISAN
Authors: Labibah Iretna
Published: June 2019

Abstract Efforts to manage sawdust waste have been carried out by society for filling up the daily life, including; as compost in industrial waste, mushroom growing media, a mixture of biobriquette making, improvement in the quality of used cooking oil, besides sawdust, there is also coffee pulp waste which is still rarely used by the community. Coffee grounds are no longer brewed and drunk, but are dumped in trash in general. This prompted the author to carry out an innovation using sawdust and coffee powder as the basic material for making entrepreneurial activities in the form of ART SPIDER (COFFEE POWDER AND SAWS ARTS). This research method uses literature review, observation and making paintings. The implementation procedure consists of four stages namely; preparation, implementation, marketing and reporting. The advantages of SPIDER ART products are products that are environmentally friendly, affordable prices with consumers can choose the desired frame shape and painting, and this product is suitable for use as souvenirs, gifts, or as wall decorations so that the room decor is more beautiful.Keywords: Sawdust, Coffee Dust, Art..AbstrakUpaya pengelolaan limbah serbuk gergaji sudah banyak dilakukan oleh masyarakat untuk memenuhi kehidupan sehari-hari diantaranya; sebagai kompos dalam limbah industri, media tanam jamur, campuran pembuatan biobriket, peningkatan kualitas minyak goreng bekas, selain serbuk gergaji ada juga limbah ampas kopi yang masih jarang dimanfaatkan oleh masyarakat. Ampas kopi tidak lagi untuk diseduh dan diminum, melainkan dibuang di tempat sampah pada umumnya. Hal tersebut mendorong penulis untuk melakukan sebuah inovasi menggunakan serbuk gergaji dan serbuk kopi sebagai bahan dasar pembuatan kegiatan kewirausahaan berupa SPIDER ART (SENI SERBUK KOPI DAN GERGAJI). Metode penelitian ini mengggunakan kajian literatur, observasi dan pembuatan lukisan. Prosedur pelaksanaan terdiri dari empat tahap yakni; persiapan, pelaksanaan, pemasaran dan laporan. Keunggulan dari produk SPIDER ART adalah produk yang ramah lingkungan, harga yang terjangkau dengan konsumen dapat memilih bentuk frame dan lukisan yang diinginkan, dan produk ini cocock untuk digunakan sebagai sovenir, kado, atau sebagai hiasan dinding sehingga dekorasi ruangan lebih indah. Kata Kunci: Serbuk Gergaji, Serbuk Kopi, Seni.