bluuebunny/crossref_metadata_2025 huggingface dataset:
Attribution of 2012 extreme climate events: does air-sea interaction matter?
Authors: Dong Buwen , Sutton Rowan T. , Shaffrey Len , Wilcox Laura J.
Published: June 2020

In 2012, extreme anomalous climate conditions occurred around the globe. Large areas of North America experienced an anomalously hot summer, with large precipitation deficits inducing severe drought. Over Europe, the summer of 2012 was marked by strong precipitation anomalies with the UK experiencing its wettest summer since 1912 while Spain suffered severe drought. What caused these extreme climate conditions in various regions in 2012? This study compares attribution conclusions for 2012 climate anomalies relative to a baseline period (1964–1981) based on two sets of parallel experiments with different model configurations (with coupling to an ocean mixed layer model or with prescribed sea surface temperatures) to assess whether attribution conclusions concerning the climate anomalies in 2012 are sensitive to the representation of air-sea interaction. Modelling results indicate that attribution conclusions for large scale surface air temperature (SAT) changes in both boreal winter and summer are generally robust and not very sensitive to air-sea interaction. This is especially true over southern Europe, Eurasia, North America, South America, and North Africa. Some other responses also appear to be insensitive to air-sea interaction: for example, forced increases in precipitation over northern Europe and Sahel, and reduced precipitation over North America and the Amazon in boreal summer. However, the attribution of circulation and precipitation changes for some other regions exhibits a sensitivity to air-sea interaction. Results from the experiments including coupling to an ocean mixed layer model show a positive NAO-like circulation response in the Atlantic sector in boreal winter and weak changes in the East Asian summer monsoon and precipitation over East Asia. With prescribed sea surface temperatures, some different responses arise over these two regions. Comparison with observed changes indicates that the coupled simulations generally agree better with observations, demonstrating that attribution methods based on atmospheric general circulation models have limitations and may lead to erroneous attribution conclusions for regional anomalies in circulation, precipitation and surface air temperature.
Non-invasive risk-assessment and bleeding prophylaxis with IVIG in pregnant women with a history of fetal and neonatal alloimmune thrombocytopenia: management to minimize adverse events
Authors: Wienzek-Lischka Sandra , Sawazki Angelika , Ehrhardt Harald , Sachs Ulrich J. , Axt-Fliedner Roland , Bein Gregor
Published: June 2020

Introduction

In pregnant women with a history of fetal and neonatal alloimmune thrombocytopenia (FNAIT), prenatal intervention in subsequent pregnancies may be required to prevent fetal bleeding. Several invasive and non-invasive protocols have been published: amniocentesis for fetal genotyping, fetal blood sampling for the determination of fetal platelet count, intrauterine platelet transfusions, and weekly maternal i.v. immunoglobulin (IVIG) infusion with or without additional corticosteroid therapy. This is the first retrospective study that report the experience with a non-invasive protocol focused on side effects of maternal IVIG treatment and neonatal outcome.

Methods

Pregnant women with proven FNAIT in history and an antigen positive fetus were treated with IVIG (1 g/kg/bw) every week. To identify potential IVIG-related hemolytic reactions isoagglutinin titer of each IVIG lot and maternal blood count were controlled. IVIG-related side effects were prospectively documented and evaluated. Furthermore, ultrasound examination of the fetus was performed before starting IVIG administration and continued regularly during treatment. Outcome of the index and subsequent pregnancy was compared. Corresponding data of the newborns were analyzed simultaneously.

Results

IVIG was started at 20 weeks of gestation (median). Compared to the index pregnancy, platelet counts of the newborns were higher in all cases. No intracranial hemorrhage occurred (Index pregnancies: 1 case). Platelet counts were 187 × 109/l (median, range 22–239, 95% CI) and one newborn had mild bleeding. No severe hemolytic reaction was observed and side effects were moderate.

Conclusion

Among pregnant women with FNAIT history, the use of non-invasive fetal risk determination and maternal IVIG resulted in favorite outcome of all newborns. Invasive diagnostic or therapeutic procedures in women with a history of FNAIT should be abandoned.
Follow-up after neonatal heart disease repair: watch out for chronic kidney disease and hypertension!
Authors: Huynh Louis , Rodriguez-Lopez Sara , Benisty Kelly , Dancea Adrian , Garros Daniel , Hessey Erin , Joffe Ari , Joffe Rachel , Mackie Andrew , Palijan Ana , Paun Alex , Pizzi Michael , Zappitelli Michael , Morgan Catherine
Published: June 2020

Background

With advances in care, neonates undergoing cardiac repairs are surviving more frequently. Our objectives were to 1) estimate the prevalence of chronic kidney disease (CKD) and hypertension 6 years after neonatal congenital heart surgery and 2) determine if cardiac surgery-associated acute kidney injury (CS-AKI) is associated with these outcomes.

Methods

Two-center prospective, longitudinal single-visit cohort study including children with congenital heart disease surgery as neonates between January 2005 and December 2012. CKD (estimated glomerular filtration rate < 90 mL/min/1.73m2 or albumin/creatinine ≥3 mg/mmol) and hypertension (systolic or diastolic blood pressure ≥ 95th percentile for age, sex, and height) prevalence 6 years after surgery was estimated. The association of CS-AKI (Kidney Disease: Improving Global Outcomes definition) with CKD and hypertension was determined using multiple regression.

Results

Fifty-eight children with median follow-up of 6 years were evaluated. CS-AKI occurred in 58%. CKD and hypertension prevalence were 17% and 30%, respectively; an additional 15% were classified as having elevated blood pressure. CS-AKI was not associated with CKD or hypertension. Classification as cyanotic postoperatively was the only independent predictor of CKD. Postoperative days in hospital predicted hypertension at follow-up.

Conclusions

The prevalence of CKD and hypertension is high in children having neonatal congenital heart surgery. This is important; early identification of CKD and hypertension can improve outcomes. These children should be systematically followed for the evolution of these negative outcomes. CS-AKI defined by current standards may not be a useful clinical tool to decide who needs follow-up and who does not.
Die Semantik des „guten Sterbens“ aus ethischer Perspektive
Authors: Breitsameter Christof
Published: June 2020

Der Beitrag will der Frage nachgehen, ob innerhalb von Hospizen und Palliativstationen in Bezug auf typische Merkmale des „guten Sterbens“ jenseits von in der Literatur erhobenen Konsensen auch Dissense beobachtet werden können, wie Sterbeverläufe, die als nicht gut betrachtet werden, zu Wort kommen, und schließlich: welche ethisch beachtlichen normativen Konsequenzen sich daraus ergeben.

Die Studie wird auf der Grundlage einer qualitativen Interviewstudie in der Befragung unterschiedlicher Akteursgruppen sowie im Vergleich dieser Gruppen durchgeführt.

Artikuliert werden – auch dissentierende – Vorstellungen von einem guten und einem schlechten Sterben, und zwar kaum von den Betroffenen und ihren Angehörigen selbst als vielmehr von den professionellen Akteuren. Die Ausprägung einer solchen Semantik hängt mit den Erfordernissen einer Praxis zusammen, die offenbar ein Rechenschaftsbedürfnis in Form von kommunikativer Vergewisserung evoziert.

Eine abstrakte Bestimmung des „guten Sterbens“ (typischerweise: ruhig, selbstbestimmt, begleitet und gelassen) steht in Gefahr, die kontextuellen Besonderheiten der damit verbundenen Praxis nicht mehr in den Blick zu bekommen, was zu in ethischer Hinsicht problematischen Situationen führen kann.
Bilateral thoracic disc herniation with abdominal wall paresis: a case report
Authors: Butenschoen Vicki Marie , Hoenikl Lisa , Deschauer Marcus , Meyer Bernhard , Gempt Jens
Published: June 2020

We present a rare case of a patient initially presenting with unilateral abdominal wall bulging and radicular pain caused by a lateral disc herniation at Th11/12, later suffering from a hernia recurrence with bilateral disc prolapse and motor deficits. The patient underwent sequesterectomy via a right hemilaminectomy at Th11, and after 8 weeks, a bilateral sequesterectomy with semirigid fusion Th11/12 was performed. Unilateral motor deficits at the thoracic level have been discussed in case reports; a bilateral disc protrusion with abdominal wall bulging occurring as a recurrent disc herniation has never been described before.
Odontogenic causes complicating the chronic rhinosinusitis diagnosis
Authors: Wuokko-Landén Annina , Blomgren Karin , Suomalainen Anni , Välimaa Hannamari
Published: June 2020

Objectives

Chronic rhinosinusitis (CRS) frequently stems from a dental origin, although odontogenic sinusitis (OS) remains underdiagnosed amongst different professionals. This study aimed to explore how often odontogenic causes are considered when diagnosing CRS.

Materials and methods

Patient records from 374 new CRS patients treated at a tertiary-level ear, nose, and throat (ENT) clinic were selected. Entries and radiological reports were assessed exploring how often dentition was mentioned and OS was suspected, how often radiologists reported maxillary teeth, and how commonly typical OS microbial findings and unilateral symptoms occurred.

Results

Although 10.1% of the CRS diagnoses were connected to possible dental issues, teeth were not mentioned for 73.8% of patients. Radiological reports were available from 267 computed or cone beam computed tomographies, of which 25.1% did not mention the maxillary teeth. The reported maxillary teeth pathology was not considered in 31/64 (48.4%) cases. Unilateral symptoms associated with apical periodontitis (OR = 2.49, 95% CI 1.27–4.89, p = 0.008). Microbial samples were available from 88 patients, for whom Staphylococcus aureus was the most common finding (17% of samples).

Conclusions

Odontogenic causes are often overlooked when diagnosing CRS. To provide adequate treatment, routine assessment of patient’s dental history and status, careful radiograph evaluation, and utilization of microbial findings should be performed. Close cooperation with dentists is mandatory.

Clinical relevance

Dental professionals should be aware of difficulties medical professionals encounter when diagnosing possible OS. Thus, sufficient knowledge of OS pathology is essential to both medical and dental professionals.
Optical measurements of oil release from calcite packed beds in microfluidic channels
Authors: Le-Anh Duy , Rao Ashit , Ayirala Subhash C. , Alotaibi Mohammed B. , Duits Michel H. G. , Gardeniers Han , Yousef Ali A. , Mugele Frieder
Published: June 2020

To enable the study of improved oil recovery (IOR) from carbonate rock via laboratory experiments at the pore scale, we have developed a novel microfluidic chip containing a 3D packed bed of calcite particles. The utilization of fluorescently labeled water phase enabled visualization up to 1–2 particle layers with confocal laser scanning microscopy. Porosity and residual oil saturation (ROS) in this space are quantified from image stacks in the depth direction (Z). To obtain reliable average ROS values,Zstacks are captured at variousXYlocations and sampled over several time-steps in the steady state. All image stacks are binarized using Otsu’s method, subsequent to automated corrections for imperfect illumination andZ-drifts of the microscope stage. Low salinity IOR was mimicked using a packed bed that was initially saturated with water and then with mineral oil. Steady state ROS values showed no significant dependence on capillary number (Ca) in the range from 6 × 10–7to 2 × 10–5. In contrast, chemical modification of the pore space via adsorption of water-extracted crude oil components yielded significantly higher ROS values, in agreement with a more oil-wet porous medium. These results indicate a good potential for using packed beds on a chip as an efficient screening tool for the optimization and development of different IOR methods.
Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals
Authors: Möller Jens , Musella Luca , Melnikov Vyacheslav , Geißdörfer Walter , Burkovski Andreas , Sangal Vartul
Published: June 2020

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.
Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study
Authors: Buono Giuseppe , Crispo Anna , Giuliano Mario , De Angelis Carmine , Schettini Francesco , Forestieri Valeria , Lauria Rossella , De Laurentiis Michelino , De Placido Pietro , Rea Carmen Giusy , Pacilio Carmen , Esposito Emanuela , Grimaldi Maria , Nocerino Flavia , Porciello Giuseppe , Giudice Aldo , Amore Alfonso , Minopoli Anita , Botti Gerardo , De Placido Sabino , Trivedi Meghana V. , Arpino Grazia
Published: June 2020

Purpose

Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) and its components on early BC (eBC) patients’ outcome.

Methods

MetS was defined by the presence of 3 to 5 of the following components: waist circumference > 88 cm, blood pressure ≥ 130/≥ 85 mmHg, serum levels of triglycerides ≥ 150 mg/dL, high density lipoprotein < 50 mg/dL and fasting glucose ≥ 110 mg/dL. Seven hundred and seventeen patients with data on ≥ 4 MetS components at BC diagnosis were enrolled. Study population was divided into two groups: patients with < 3 (non-MetS) vs. ≥ 3 components (MetS). Categorical variables were analyzed by Chi-square test and survival data by log-rank test and Cox proportional hazards regression model.

Results

Overall, 544 (75.9%) and 173 (24.1%) women were categorized as non-MetS and MetS, respectively. MetS patients were more likely to be older, postmenopausal, and insulin-resistant compared to non-MetS patients (p < 0.05). In multivariate analysis, MetS patients had a numerically higher risk of relapse [disease-free survival (DFS), hazard ratio (HR) 1.51, p = 0.07] and a significantly higher risk of death compared to non-MetS patients [overall survival (OS), HR 3.01, p < 0.0001; breast cancer-specific survival (BCSS), HR 3.16, p = 0.001]. Additionally, patients with 1 to 2 components of MetS had an increased risk of dying compared to patients with 0 components (OS, HR 4.90, p = 0.01; BCSS, HR 6.07, p = 0.02).

Conclusions

MetS correlated with poor outcome in eBC patients. Among patients without full criteria for MetS diagnosis, the presence of 1 or 2 components of the syndrome may predict for worse survival.
Integrative analysis of key candidate genes and signaling pathways in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy by bioinformatics
Authors: Zhang Ying , Garofano Francesca , Wu Xiaolong , Schmid Matthias , Krawitz Peter , Essler Markus , Schmidt-Wolf Ingo G. H.
Published: June 2020

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), the first immune checkpoint to be targeted clinically, has provided an effective treatment option for various malignancies. However, the clinical advantages associated with CTLA-4 inhibitors can be offset by the potentially severe immune-related adverse events (IRAEs), including autoimmune thyroid dysfunction. To investigate the candidate genes and signaling pathways involving in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy, integrated differentially expressed genes (DEGs) were extracted from the intersection of genes from Gene Expression Omnibus (GEO) datasets and text mining. The functional enrichment was performed by gene ontology (GO) annotation and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis. Protein-protein interaction (PPI) network, module enrichment, and hub gene identification were constructed and visualized by the online Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape software. A total of 22 and 17 integrated human DEGs in hypothyroidism and hyperthyroidism group related to anti-CTLA-4 therapy were identified, respectively. Functional enrichment analysis revealed 24 GO terms and 1 KEGG pathways in the hypothyroid group and 21 GO terms and 2 KEGG pathways in the hyperthyroid group. After PPI network construction, the top five hub genes associated with hypothyroidism were extracted, including ALB, MAPK1, SPP1, PPARG, and MIF, whereas those associated with hyperthyroidism were ALB, FCGR2B, CD44, LCN2, and CD74. The identification of the candidate key genes and enriched signaling pathways provides potential biomarkers for autoimmune thyroid dysfunction related to anti-CTLA-4 therapy and might contribute to the future diagnosis and management of IRAEs for cancer patients.
Watch the colors: or about qualitative thinking in chemistry
Authors: Grochala Wojciech
Published: June 2020

The importance of watching and understanding color of chemical compounds and linking it to diverse physical and chemical properties is illustrated here using transition metal oxides at the highest achievable oxidation state of a metal. Analyses are based on qualitative thinking supported by Molecular Orbital theory in its simplest implementation.

Graphic abstract
COVID-19 and digital disruption in UK universities: afflictions and affordances of emergency online migration
Authors: Watermeyer Richard , Crick Tom , Knight Cathryn , Goodall Janet
Published: June 2020

COVID-19 has caused the closure of university campuses around the world and migration of all learning, teaching, and assessment into online domains. The impacts of this on the academic community as frontline providers of higher education are profound. In this article, we report the findings from a survey ofn = 1148 academics working in universities in the United Kingdom (UK) and representing all the major disciplines and career hierarchy. Respondents report an abundance of what we call ‘afflictions’ exacted upon their role as educators and in far fewer yet no less visible ways ‘affordances’ derived from their rapid transition to online provision and early ‘entry-level’ use of digital pedagogies. Overall, they suggest that online migration is engendering significant dysfunctionality and disturbance to their pedagogical roles and their personal lives. They also signpost online migration as a major challenge for student recruitment, market sustainability, an academic labour-market, and local economies.
9-Acridinemethanamine and Acridine-9-Carboxaldehyde as Potential Fluorescence Lifetime pH Indicators
Authors: Totland Christian , Thomas Peter J. , Holst Bodil , Akhtar Naureen , Hovdenes Jostein , Skodvin Tore
Published: June 2020

A significant challenge concerning the development of fluorescence lifetime (FL) based pH sensors is the paucity of fluorophores with sufficiently large FL variation with pH. Acridine is amongst the indicators with highest fluoresce lifetime responses to pH, with a change in lifetime of about 13 ns within a pH range of 5–8. Here we examine the two acridine derivatives, 9-acridinemethanamine (9-AMA) and acridine-9-carbaldehyde (9-ACA) in terms of their FL pH sensitivity and pH sensing range. Both indicators are characterized when dissolved in buffer solutions, as well as when immobilized in support materials. 9-AMA has a change in FL of 11 ns between pH 2–5, both when dissolved in solution and when immobilized in surfactant-filled mesoporous silica. The FL of 9-ACA is not sensitive to pH when dissolved in buffer solutions; however, when covalently bound to amine-modified silica, its FL changes 15 ns between pH 3–6. 9-AMA and 9-ACA represent promising FL in the pH range of pH 2–6, and could potentially form the basis of new FL pH sensors.
Ethical Considerations of Using Machine Learning for Decision Support in Occupational Health: An Example Involving Periodic Workers’ Health Assessments
Authors: Six Dijkstra Marianne W. M. C. , Siebrand Egbert , Dorrestijn Steven , Salomons Etto L. , Reneman Michiel F. , Oosterveld Frits G. J. , Soer Remko , Gross Douglas P. , Bieleman Hendrik J.
Published: June 2020

PurposeComputer algorithms and Machine Learning (ML) will be integrated into clinical decision support within occupational health care. This will change the interaction between health care professionals and their clients, with unknown consequences. The aim of this study was to explore ethical considerations and potential consequences of using ML based decision support tools (DSTs) in the context of occupational health.MethodsWe conducted an ethical deliberation. This was supported by a narrative literature review of publications about ML and DSTs in occupational health and by an assessment of the potential impact of ML-DSTs according to frameworks from medical ethics and philosophy of technology. We introduce a hypothetical clinical scenario from a workers’ health assessment to reflect on biomedical ethical principles: respect for autonomy, beneficence, non-maleficence and justice.ResultsRespect for autonomy is affected by uncertainty about what future consequences the worker is consenting to as a result of the fluctuating nature of ML-DSTs and validity evidence used to inform the worker. A beneficent advisory process is influenced because the three elements of evidence based practice are affected through use of a ML-DST. The principle of non-maleficence is challenged by the balance between group-level benefits and individual harm, the vulnerability of the worker in the occupational context, and the possibility of function creep. Justice might be empowered when the ML-DST is valid, but profiling and discrimination are potential risks.ConclusionsImplications of ethical considerations have been described for the socially responsible design of ML-DSTs. Three recommendations were provided to minimize undesirable adverse effects of the development and implementation of ML-DSTs.
The Prangos genus: a comprehensive review on traditional use, phytochemistry, and pharmacological activities
Authors: Mottaghipisheh Javad , Kiss Tivadar , Tóth Barbara , Csupor Dezső
Published: June 2020

The members of the Prangos genus (Apiaceae) have been widely applied in the Iranian traditional medicine internally and externally for different purposes. The aim of this review is to summarize the ethnomedicinal and food applications of Prangos species and to gather the phytochemical and pharmacological data on this genus. Among the 129 constituents isolated from Prangos species, coumarin derivatives are the main compounds. Several papers report the compositions of essential oils obtained from different plant parts, mostly containing monoterpene and sesquiterpene hydrocarbons. Various pharmacological activities of essential oils, crude extracts or isolated compounds of the Prangos species have been observed, primarily in in vitro experiments. Antioxidant, antimicrobial, cytotoxic and anti-proliferative activities have been the most extensively studied. The efficacy and safety of Prangos plants have not been assessed in animal experiments or clinical trials. Although their furocoumarin content might be a source of adverse effects, toxic effects of Prangos species have not been reported. It can be concluded, that further preclinical and clinical data are necessary to assess the rationale and safety of the medicinal and food use of Prangos species.
An update of the Worldwide Integrated Assessment (WIA) on systemic pesticides. Part 4: Alternatives in major cropping systems
Authors: Veres Andrea , Wyckhuys Kris A. G. , Kiss Jozsef , Tóth Ferenc , Burgio Giovanni , Pons Xavier , Avilla Carlos , Vidal Stefan , Razinger Jaka , Bazok Renata , Matyjaszczyk Ewa , Milosavljević Ivan , Le Xuan Vi , Zhou Wenwu , Zhu Zeng-Rong , Tarno Hagus , Hadi Buyung , Lundgren Jonathan , Bonmatin Jean-Marc , van Lexmond Maarten Bijleveld , Aebi Alexandre , Rauf Aunu , Furlan Lorenzo
Published: June 2020

We present a synthetic review and expert consultation that assesses the actual risks posed by arthropod pests in four major crops, identifies targets for integrated pest management (IPM) in terms of cultivated land needing pest control and gauges the implementation “readiness” of non-chemical alternatives. Our assessment focuses on the world’s primary target pests for neonicotinoid-based management: western corn rootworm (WCR, Diabrotica virgifera virgifera) in maize; wireworms (Agriotes spp.) in maize and winter wheat; bird cherry-oat aphid (Rhopalosiphum padi) in winter wheat; brown planthopper (BPH, Nilaparvata lugens) in rice; cotton aphid (Aphis gossypii) and silver-leaf whitefly (SLW, Bemisia tabaci) in cotton. First, we queried scientific literature databases and consulted experts from different countries in Europe, North America, and Asia about available IPM tools for each crop-pest system. Next, using an online survey, we quantitatively assessed the economic relevance of target pests by compiling country-level records of crop damage, yield impacts, extent of insecticide usage, and “readiness” status of various pest management alternatives (i.e., research, plot-scale validation, grower-uptake). Biological control received considerable scientific attention, while agronomic strategies (e.g., crop rotation), insurance schemes, decision support systems (DSS), and innovative pesticide application modes were listed as key alternatives. Our study identifies opportunities to advance applied research, IPM technology validation, and grower education to halt or drastically reduce our over-reliance on systemic insecticides globally.
The Third Age: Reflections on Our Hidden Material Core
Authors: Škof Lenart
Published: June 2020

This paper deals with the concept of three eras, as brought to us firstly in the Babylonian Talmud, and later reshaped and reformulated by Christian theologians Joachim of Fiore, Amalric of Bène, and finally by Luce Irigaray. In the first part, we start with the idea of the three eras. This is followed by a critical approach to Sloterdijk’s You must change your life in which religion is substituted by the anthropotechnics. We argue that even in these secular times, the salvation history still remains unfulfilled and that our world is in need of a new, post-Christian materially spiritual narrative. The second part is entirely dedicated to Amalricians and their teachings. Also by tackling strong Islamic influences, we try to find a new opening towards the post-Christian era beyond the mentioned anthropotechnics/atheism divide. In the third part, the Age of the Spirit is approached and defined as a future messianic-utopian era in which a hidden and forgotten inner spiritual core will be revealed to us and in which humanity will give itself a gift of becoming spiritually transformed and divinized.
First-Line Management of Advanced High-Grade Serous Ovarian Cancer
Authors: Mahmood Reem D. , Morgan Robert D. , Edmondson Richard J. , Clamp Andrew R. , Jayson Gordon C.
Published: June 2020

Purpose of Review

Epithelial ovarian cancer is a disease that encompasses a number of histologically and molecularly distinct entities; the most prevalent subtype being high-grade serous (HGS) carcinoma. Standard first-line treatment of advanced HGS carcinoma includes cytoreductive surgery plus intravenous paclitaxel/platinum-based chemotherapy. Despite excellent responses to initial treatment, the majority of patients develop recurrent disease within 3 years. The introduction of the vascular endothelial growth factor (VEGF) inhibitor, bevacizumab, and poly(ADP-ribose) polymerase (PARP) inhibitors into first-line management has changed the outlook for this lethal disease. In this review, we summarise the most recent clinical trials that determine current primary therapy of advanced HGS carcinoma and the ongoing trials that aim to change management in the future.

Recent Findings

Recent phase III clinical trials have shown that delayed primary surgery after completing neo-adjuvant chemotherapy is non-inferior to immediate primary surgery, but could provide a survival benefit in FIGO (International Federation of Gynecology and Obstetrics) stage IV disease. The use of weekly intravenous chemotherapy regimens has not been proven to be more effective than standard 3-weekly regimens in Western patient populations, and the use of intraperitoneal chemotherapy remains controversial in the first-line setting. In contrast, newer systemic anti-cancer therapies targeting angiogenesis and/or HR-deficient tumours have been successfully incorporated into front-line therapeutic regimens to treat HGS carcinoma. Recent results from randomised trials investigating the use of PARP inhibitors as monotherapy and in combination with the anti-angiogenic agent, bevacizumab, have demonstrated highly impressive efficacy when combined with traditional first-line multi-modality therapy.

Management of HGS carcinoma is evolving, but further work is still required to optimise and integrate tumour and plasma biomarkers to exploit the potential of these highly efficacious targeted agents.
1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase
Authors: Sophocleous Georgios , Wood George , Owen Darerca , Mott Helen R.
Published: June 2020

PRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like domain that targets it to the plasma membrane and a kinase domain, which is a member of the protein kinase C superfamily. PRK1 is involved in cytoskeletal regulation, cell adhesion, cell cycle progression and the immune response, and is implicated in cancer. There is currently no structural information for the HR1c domain. The1H,15N and13C NMR backbone and sidechain resonance assignment of the HR1c domain presented here forms the basis for this domain’s structural characterisation. This work will also enable studies of interactions between the three HR1 domains in an effort to obtain structural insight into the regulation of PRK1 activity.
Efficient estimation of hydraulic conductivity heterogeneity with non-redundant measurement information
Authors: Carrera Barbara , Mok Chin Man , Papaioannou Iason
Published: June 2020

Solving the inverse problem of identifying groundwater model parameters with measurements is a computationally intensive task. Although model reduction methods provide computational relief, the performance of many inversion methods depends on the amount of often highly correlated measurements. We propose a measurement reduction method that only incorporates essential measurement information in the inversion process. The method decomposes the covariance matrix of the model output and projects both measurements and model response on the eigenvector space corresponding to the largest eigenvalues. We combine this measurement reduction technique with two inversion methods, the Iterated Extended Kalman Filter (IEKF) and the Sequential Monte Carlo (SMC) methods. The IEKF method linearizes the relationship between measurements and parameters, and the cost of the required gradient calculation increases with increase of the number of measurements. SMC is a Bayesian updating approach that samples the posterior distribution through sequentially sampling a set of intermediate measures and the number of sampling steps increases with increase of the information content. We propose modified versions of both algorithms that identify the underlying eigenspace and incorporate the reduced information content in the inversion process. The performance of the modified IEKF and SMC methods with measurement reduction is tested on a numerical example that illustrates the computational benefit of the proposed approach as compared to the standard IEKF and SMC methods with full measurement sets.
MusicMatic – The French Supreme Court’s Decision on Creative Commons Plus (CC+) Commercial Licensing and Mandatory Collective Management of the Right to Remuneration for Communication to the Public of Commercial Phonograms
Authors: Bulayenko Oleksandr
Published: June 2020

The French Supreme Court established that businesses using on their premises devices provided by third parties for making background music are performing an act of communication to the public in the sense of Art. L214-1 of the French Intellectual Property Code (CPI). The Court qualified commercially licensed phonograms, also published under Creative Commons non-commercial licences (CC BY-NC-ND 3.0) on the Jamendo online platform, as “phonograms published for commercial purposes”. According to the Court, the right to remuneration for communication to the public of phonograms published for commercial purposes cannot be contractually waived by performers. The right to remuneration is subject to mandatory management by a collective management organisation (CMO) regardless of whether rightholders have explicitly contractually entrusted the exercise of their rights to the CMO. Mandatory collective management of the right to remuneration for communication to the public of phonograms published for commercial purposes is compatible with EU law. The Supreme Court declined to refer the question of the compatibility of mandatory collective management to the Court of Justice of the European Union (CJEU), considering that the law is sufficiently clear in this regard.
Estimation of socioeconomic attributes from location information
Authors: Doi Shohei , Mizuno Takayuki , Fujiwara Naoya
Published: June 2020

Timely estimation of the distribution of socioeconomic attributes and their movement is crucial for academic as well as administrative and marketing purposes. In this study, assuming personal attributes affect human behavior and movement, we predict these attributes from location information. First, we predict the socioeconomic characteristics of individuals by supervised learning methods, i.e., logistic Lasso regression, Gaussian Naive Bayes, random forest, XGBoost, LightGBM, and support vector machine, using survey data we collected of personal attributes and frequency of visits to specific facilities, to test our conjecture. We find that gender, a crucial attribute, is as highly predictable from locations as from other sources such as social networking services, as done by existing studies. Second, we apply the model trained with the survey data to actual GPS log data to check the performance of our approach in a real-world setting. Though our approach does not perform as well as for the survey data, the results suggest that we can infer gender from a GPS log.
Reproduktive Freiheit für wen?
Authors: Beck Birgit
Published: June 2020

Der vorliegende Kommentar wirft, nach einer knappen Zusammenfassung der Argumentation des Beitrags von Tatjana Tarkian, einige grundsätzliche Fragen auf, welche die Geltungsreichweite und Anwendbarkeit der Prinzipien der reproduktiven Autonomie und der wohltätigen Fortpflanzung betreffen. Welche prospektiven Eltern sind Adressat*innen der Prinzipien der reproduktiven Freiheit und der wohltätigen Fortpflanzung? Stellen diese Prinzipien universell und überzeitlich gültige allgemeine Prinzipien dar, die generell in jeder Situation reproduktiver Entscheidung Berücksichtigung finden sollten? Lassen sie sich nur unter der Voraussetzung bestimmter Bedingungen bzw. im Rahmen bestimmter Kontexte anwenden? Sind die beiden Prinzipien kompatibel oder widersprechen sie sich? Kommt prospektiven Eltern eine moralische Verantwortung für die Umsetzbarkeit ihrer reproduktiven Freiheit zu?
Stability Design for the Homogeneous Platoon with Communication Time Delay
Authors: Ma Fangwu , Wang Jiawei , Yang Yu , Wu Liang , Zhu Sheng , Gelbal Sukru Yaren , Aksun-Guvenc Bilin , Guvenc Levent
Published: June 2020

A hierarchical control framework is applied for the distributed cooperative vehicular platoon using vehicular ad-hoc networks. The parameter-space-approach-based cooperative adaptive cruise control (CACC) controller is proposed to guarantee the $${\mathcal{D}}$$D-stability and the string stability considering the influence of the communication time delay and time lag of vehicular dynamic performance. This CACC controller combines the feedforward loop of the acceleration of the preceding vehicle with the feedback loop of the following errors, in which the gain of the feedforward loop is designed to decrease matching errors and the gains of the feedback loop are selected from the feasible region in the parameter space. To verify the effectiveness of the CACC controller, a six-vehicle platoon with a simplified vehicular dynamic is simulated under speed-up and stop scenarios. The simulation results demonstrate that the disturbance is attenuated along with the platoon and the following errors are convergent with well-designed convergent performance. A CarSim/Simulink co-simulation is designed to further verify the effectiveness of the hierarchical control framework and the rationality of the CACC controller in the real vehicular platoon application. The simulation results under the highway fuel economy test drive cycle show that the CACC controller improves the drive comfort and significantly decreases the following errors.
Biologia Futura: landscape perspectives on farmland biodiversity conservation
Authors: Batáry Péter , Báldi András , Ekroos Johan , Gallé Róbert , Grass Ingo , Tscharntke Teja
Published: June 2020

European nature conservation has a strong focus on farmland harbouring threatened species that mainly co-occur with traditional agriculture shaped way before the green revolution. Increased land-use intensity in agriculture has caused an alarming decline in farmland biodiversity during the last century. How can a landscape perspective contribute to fostering our understanding on causes and consequences of farmland biodiversity decline and improving the effectiveness of conservation measures? To answer these questions, we discuss the importance of landscape compositional and configurational heterogeneity, understanding ecological mechanisms determining how landscape structure affects farmland biodiversity and considering the interplay of farmland biodiversity and ecosystem service conservation.
Differential epidemiology and antibiotic resistance of lactose-fermenting and non-fermenting Escherichia coli: Is it just a matter of taste?
Authors: Gajdács Márió , Ábrók Marianna , Lázár Andrea , Burián Katalin
Published: June 2020

Urinary tract infections (UTIs) are some of the most common infections affecting humans worldwide. Occurrence of atypical, lactose non-fermenting, biochemically “inactive” strains ofE. coliin clinical material has been described in the literature, which may cause a significant diagnostic challenge. The present retrospective microbiological study was carried out using isolates and data collected between January 1, 2013, and December 31, 2017, at the Institute of Clinical Microbiology.n = 24,285 positive urine samples were noted during the study period, out of which, samples positive for eitherlac + andlac-E. coliwere included in the analysis.E. colirepresentedn = 7075 (55.8% ± 4.6%) of outpatient andn = 4916 (42.4% ± 3.6%) of inpatient isolates.n = 401 (3.3%; 80.2 ± 14.6/year)lac-E. coliisolates were identified from urinary tract infections. The ratio oflac-E. coliisolates was significantly higher in outpatient samples (262 vs. 139). Resistance levels oflac- isolates for antibiotics commonly used for treating UTIs were significantly higher for both inpatient and outpatient isolates: norfloxacin, ciprofloxacin, fosfomycin and nitrofurantoin. It is essential to pay attention to the presence oflac- strains, and their omission from clinical material during diagnostic procedures may have significant consequences for epidemiological studies and therapy.
Immune differences in captive and free-ranging zebras (Equus zebra and E. quagga)
Authors: Seeber Peter A. , Morrison Thomas , Ortega Alix , East Marion L. , Greenwood Alex D. , Czirják Gábor Á.
Published: June 2020

Wild mammals in ex situ captivity experience substantially different environmental conditions compared to free-ranging conspecifics, e.g., in terms of diet, climatic conditions, social factors, movement space, and direct anthropogenic disturbance. Moreover, animals in captivity frequently undergo management interventions such as medical treatments which may influence pathogen pressure. Captivity is known to affect immunological responses in some terrestrial and marine mammals; however, it is unclear whether this can be generalized to other taxa. Furthermore, little is known about how energetically costly life history stages such as lactation influence the immune system in wildlife. We measured expression of components of the constitutive and induced innate immunity and of the adaptive immune system in plains and mountain zebras (Equus quagga and E. zebra), including lactating and non-lactating individuals. As a proxy for general immune function, we screened for lytic equine herpesvirus (EHV) infection, a common and often latent pathogen which is reactivated in response to stress and immune challenge. Both energetically cheap markers of the constitutive innate immunity were lower in captive than in wild zebras, whereas energetically costly markers of the induced innate immunity were more highly expressed in captive zebras. Lactation was associated with higher titers of natural antibodies and lysozyme. Lytic EHV infection was not significantly correlated with any of the measured immune markers. Our results suggest that captivity and lactation may influence immune functions in zebra mares.
Northernmost record of reproduction of the expanding golden jackal population
Authors: Kowalczyk Rafał , Wudarczyk Michał , Wójcik Jan M. , Okarma Henryk
Published: June 2020

Golden jackal (Canis aureus) is expanding north in Europe. So far, its reproduction has rarely been reported in the expansion area. In this paper, we describe the first cases of reproduction of golden jackal from northern Poland, 500 km north from previously reported records. In summer 2015 and 2017, golden jackal juveniles (four and five individuals, respectively) sightings were recorded near Kwidzyn in Vistula river valley, where jackals have been observed repeatedly since 2015. These are the northernmost records of golden jackal reproduction in Europe. Since 2015, golden jackal was recorded in 15 locations in different parts of Poland, usually in the vicinity of larger rivers in mosaic habitats. The reproduction records suggest local establishment of population with predicted population increase and further expansion. First observation and record of reproduction in the same year suggest that expansion of golden jackal in Poland took place earlier and was not recorded, probably due to lack of knowledge on the species and failure to recognize its individuals.
The dynamics of pine marten predation on red and grey squirrels
Authors: Twining Joshua P. , Montgomery W. Ian , Tosh David G.
Published: June 2020

Invasive alien species pose one of the greatest threats to global biodiversity. In parts of Europe, introduced eastern grey squirrels (Sciurus carolinensis) have caused regional extinctions of the native red squirrel (Sciurus vulgaris). However, exposure to pine martens (Martes martes) has been demonstrated to reverse the competitive outcome between red and grey squirrels. The mechanism whereby this effect occurs remains unclear. It is hypothesised that direct predation, facilitated by a lack of behavioural response, is the mechanism driving this relationship. We review the literature and reanalyse a new dataset to provide further data on the occurrence of both squirrel species in the scats of pine marten. Both squirrel species occurred in the scats of pine marten confirming its role as a predator of these species. Predation of grey squirrels was significantly higher than red squirrels and was recorded only in spring and summer. Our review provides evidence for the mechanism driving the current decline in grey squirrels in Ireland and Scotland and supports the hypothesis that in the presence of a shared predator, direct predation influences the outcome of species interactions between native red and non-native grey squirrels.
Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
Authors: Spillinger Aviv , Low Christopher M. , Smith Byron M. , Stokken Janalee K. , O'Brien Erin K. , Choby Garret
Published: June 2020

Objective

This study aims to describe presenting characteristics of patients diagnosed with non‐invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease‐related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population.

Study design

Retrospective chart review.

Setting

An academic tertiary care center (Mayo Clinic, Rochester, Minnesota).

Subjects and methods

Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution.

Results

Fifty‐seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund–Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort.

Conclusion

The risk of developing CRS‐related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver‐ and kidney‐recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.