bluuebunny/crossref_metadata_2025 huggingface dataset:
Seroprevalence of Crimean-Congo haemorrhagic fever in Indian cattle and buffaloes
Authors: Sarangi Laxmi N , Mulpuri Hemanjali , Rana Samir K , Prasad Amitesh , Muthappa Ponnanna N
Published: December 2022

Background & objectives:

Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne viral zoonotic disease of public health importance. Cattle and buffaloes although not showing any clinical symptoms, can be infected by the CCHF virus and act as sources of infection to human beings. The prevalence of CCHF in cattle and buffaloes is important from One health perspective for control of CCHF in humans.

Methods:

A cross-sectional study was undertaken to ascertain the prevalence of CCHFV in cattle and buffaloes of India. Materials and methods: A total of 804 serum samples from four states of India (Gujarat and Rajasthan: human outbreaks reported; Punjab and Haryana: no outbreak reported) were screened by ELISA test detecting nucleoprotein antibodies of CCHFV.

Results:

The overall true prevalence was 8.63% (95% CI: 6.76% – 10.9%). The highest prevalence was recorded in Rajasthan (13.24%) followed by Gujarat (8.68%), Haryana (6.84%), and Punjab (6.51%). Prevalence of CCHF was higher in cattle (9.92%) than buffaloes (5.84%); in females (10.87%) than males (4.99%); in adults (10.18%) than young ones (5.66%). Interestingly, higher seropositivity was recorded in indigenous cattle (12.04%) than in exotic and cross-breed cattle (1.69%) which was statistically significant (p=0.001).

Interpretation & conclusion:

These findings revealed CCHF virus is circulating unnoticed and the prevalence has increased over time which is of public health concern.
Global status of Anaplasma phagocytophilum infections in human population: A 50-year (1970–2020) meta-analysis
Authors: Karshima Solomon Ngutor , Ahmed Musa Isiyaku , Mohammed Kaltume Mamman , Pam Victoria Adamu
Published: December 2022

Background & objectives:

Anaplasma phagocytophilum causes human granulocytic anaplasmosis; a febrile tick-borne bacterial zoonosis of increasing public health importance in many parts of the world which is life threatening in undiagnosed, misdiagnosed and untreated cases. In this study we determined and reported the global status of the pathogen in man.

Methods:

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was used to perform a systematic review and meta-analysis of data published in six electronic databases between 1970 and 2020. We pooled data using the random-effects model, performed sensitivity analysis by the single study deletion method and assess across study bias by the funnel plot and its statistical significance by the Egger's regression test.

Results:

A total of 7018 cases of A. phagocytophilum were reported from 48,619 individuals examined across 22 countries in three continents. Overall pooled estimate was 8.13% (95% CI: 5.70 – 11.47) with a range of 4.64 (95% CI: 1.78 – 11.54) to 12.18% (95% CI: 7.66 – 18.83) across sub-groups. Regional prevalence was highest in North America 11.07% (95% CI: 3.13 – 32.38), while that in relation to study population was highest among occupationally exposed population 11.41% (95% CI: 5.69 – 21.56).

Interpretation & conclusion:

The study revealed a significant variation in the prevalence of A. phagocytophilum across Asia, Europe and North America, with the highest prevalence in North America and among occupationally exposed population. To curtail the menace of this growing public health crisis, we recommend integrated control programmes involving tick control, the use of appropriate clothing by occupationally exposed population and health education.
Non-Motor Symptoms Burden in Early Stages of Parkinson's Disease
Authors: Sardar Zomer , Liaquat Sumayyah , Yousaf Qudsum , Bano Safia , Numan Ahsan
Published: December 2022

Background:

Non-motor symptoms (NMSs) in Parkinson's disease (PD) are often overlooked and thus can impede clinical management and significantly reduce the patient's quality of life.

Aims:

The study aimed to determine the burden of NMS in the early stages of PD.

Material and Methods:

A 1-year observational cross-sectional study was conducted at Mayo Hospital, Lahore, in 2019. The MDS-PD criteria were used to diagnose PD patients. The study included patients with Hoehn and Yahr (HY) stages 1–3. The frequency of NMSs was assessed using a non-motor symptom questionnaire (NMSQ), and the non-motor symptom scale (NMSS) score was derived using the NMSS.

Results:

A total of 100 PD patients were enrolled in the study. Sixty-three (63%) were males and 37 (37%) were females. Their age ranged between 45 and 75 years with a mean ± SD of 57.46 ± 8.46. At least one NMS was reported by 84% of patients, with neuropsychiatric symptoms (68%) preponderant, followed by a change in taste and smell (64%). The mean NMSS score is 46.22 ± 22.098 (median 44) with a range from 0 to 88, with the trend being increasing score with the advancing stage.

Conclusion:

The use of the NMSQ and NMSS tools should be standard in clinical practice to identify the severity of the disease and commence appropriate care.
Unequal Representation of Persons with Disabling Mental Health Conditions in the Quota-Based Employment Reservations Notified by a Public Service Commission
Authors: Angothu Hareesh , Philip Sharad , Jadhav Prabhu , Jayarajan Deepak , Jagannathan Aarti , Prasad Krishna M , Thirthalli Jagadish
Published: December 2022

Introduction:

The Rights of Persons with Disabilities (RPwD) Act 2016 of India intends to achieve greater representation of persons with benchmark disabilities (PwBD) at government establishments and reserve at least 4% of employment vacancies for PwBD. Of this 4%, 1% is reserved for PwBD with disabling mental health conditions (PwBD-MHC) and multiple disabilities, and 1% each for PwBD due to other disabling conditions like blindness, hearing, and locomotor impairment.

Methods:

We analyzed all the employment vacancy announcements (EVAs) made by the Indian union public service commission (UPSC) during the calendar year 2020 for their adherence to quota-based employment reservations (QBER).

Results:

Eighteen vacancy advertisements made during the year 2020, for a total of 1370 posts under various departments, announced a total of 57 posts as reserved for PwBD under the QBER system, satisfying the minimum 4% quota. However, none of these posts is reserved for PwBD-MHC. Further, only 7 out of 1370 were described as suitable for PwBD-MHC, implying that 1363 are not suitable for them.

Conclusions:

The QBER system and the subdivision of quotas are well-intended to achieve the minimum representation of PwBD across all categories of jobs. However, the EVAs by UPSC in the year 2020 did not reserve any posts for PwBD-MHC and perhaps inadvertently excluded them from consideration for the majority of posts announced even under the unreserved category.
Intention to get Vaccinated Against COVID-19 in Iranian Hospital Staff
Authors: Shirahmadi Samane , Khazaei Salman , Jalili Ebrahim , Kazemian Hasan , Sadri Mohadese , Farhadinasab Abdollah , Jenabi Ensiyeh , Bashirian Saeid
Published: December 2022

Background:

This study aimed to identify the predictors of the intention to receive the COVID-19 vaccine among Iranian health care workers (HCWs) based on the Theory of Planned Behavior (TPB).

Methods:

The study was a descriptive cross-sectional study that was conducted on 473 personnel working in hospitals of Hamadan, in May 2021 and before COVID-19 vaccination on hospital staff. The multi-stage sampling method was used for choosing participants. The survey included socio-demographic, questions related to TPB dimensions, and intention to receive a COVID-19 vaccine. Qualitative and quantitative data analyses were performed using the Chi-square test and T-test, respectively. Predictors of COVID-19 vaccination intention were determined using the logistic regression model.

Results:

Seventy percent of 361 eligible respondents stated their willingness to receive COVID-19 vaccine. The participants with the intention to receive COVID-19 vaccine had higher scores of attitude (7.25 ± 3.92 vs. 4.40 ± 5.14) and norm (3.04 ± 2.92 vs. -0.5 ± 3.18) (P < 0.001). Having an underlying disease and being married were significantly associated with the intention to receive COVID-19 vaccine (P < 0.05). Higher attitude and norm scores as a construct of the TPB were associated with an increase in intention to receive COVID-19 vaccine.

Conclusions:

The results of this study showed that the vaccination intention was affected by social, demographic, health, and behavioral features, such as age, marital status, underlying diseases, subjective norms, and attitude. Therefore, age groups below 50, single people, and those with no underlying diseases were eligible to be the target of interventional programs.
A prospective cohort study to evaluate the outcome of COVID-19 infection in pregnant women in a tertiary care hospital
Authors: Choudhury Mili D. , Ghose Sivaji S. , Maiti G. D.
Published: December 2022

Background:

Worldwide COVID-19 infection has played havoc. The number of COVID-positive pregnant cases in this study was not far behind the National average. The present study was conducted to evaluate the outcome of COVID-19 infection in pregnant women during their antenatal, intrapartum, and postnatal periods.

Methodology:

The study design was a prospective cohort study. The total number of COVID-19 pregnant patients admitted to this tertiary care hospital from March 2020 to June 2021 was 106 cases at various trimesters. This hospital caters to serving personnel, ex-servicemen, and dependents of the Indian Armed Forces. The community being studied were only the dependents and the serving female personnel. Proper history, presenting complaints, period of gestation, obstetric and systemic examination findings, the severity of symptoms, home isolation or hospital stay, and treatment were all recorded in the form of the questionnaire. Finally, the antenatal, intrapartum, postnatal, and neonatal outcomes of these COVID-positive pregnant patients were compiled and studied.

Results:

The prevalence of COVID-positive pregnant women in the community being studied was 9.9%. About 43.39% of the cases were diagnosed in the third trimester. Ninety-three percent of the patients in the present study were asymptomatic or with very mild symptoms. The mode of delivery in the present study was mostly by cesarean section (69.56%).

Conclusion:

In the present study, pregnancy-associated complications were within the range of 2.8%–3% and only two newborns were COVID positive.
The Alkaloids of Isatis indigotica as Promising Candidates against COVID-19
Authors: Kazemi Farnoosh , Mojarrab Mahdi , Bahrami Gholamreza , Miraghaei Seyed Shahram , Hadidi Saba , Majnooni Mohammad Bagher
Published: December 2022

Background:

Due to the complexities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an effective medicinal treatment protocol for this lethal disease with a high prevalence has not been approved yet. This study aimed to explore the efficacy of the main alkaloids of Isatis indigotica, one of the richest plant sources of alkaloids against SARS-CoV-2 targets computationally.

Materials and Methods:

3D structures of the target proteins including 3CLpro; PLpro, and RdRp were downloaded from Protein Data Bank. The structures of ligands were retrieved from PubChem database or optimized by ORCA program. Ritonavir, Lopinavir, Sofosbuvir, and Remdesivir were selected as control inhibitors. Docking calculations were performed by AutoDock Vina option and top-ranked compounds were subjected to molecular dynamics simulation by Gromacs 5.1.4 simulation package.

Result:

The results showed that all 15 compounds had stronger interactions with PLpro in comparison to the other enzymes. Dihydroxylisopropylidenylisatisine A binds to the active site of PLpro with highest affinity (–9.3 kcal/mol) which is even more than the binding constants of Ritonavir and Lopinavir. Of the 15 compounds, Dihydroxylisopropylidenylisatisine A and Isatibisindosulfonic acid B had the highest tendency to bind to 3CLpro. Dihydroxylisopropylidenylisatisine A, Indirubin, Insatindibisindolamide A, Indigo, Insatindibisindolamide B, Isatibisindosulfonic acid B and Isatindosulfonic acid B had the highest RdRp binding affinity even more Remdesivir.

Conclusion:

Based on the results, the highest and weakest interaction with all three enzymes was observed for Dihydroxylisopropylidenylisatisine A and Epigoitrin, respectively. Based on these findings, Dihydroxylisopropylidenylsatistine A might be potential therapeutic candidate against SARS-CoV-2.
Healing Effect of Hydroalcoholic Extract of Humulus lupulus L. (Hops) Aerial Parts on Indomethacin-induced Gastric Ulcer in Rats
Authors: Minaiyan Mohsen , Razzaghi Hamidreza , Yegdaneh Afsaneh , Talebi Ardeshir
Published: December 2022

Background:

Humulus lupulus L. (Hops) is one of the medicinal plants for which several effects have been reported such as sedative and hypnotic, anti-inflammatory, antioxidant, antibacterial, and anticancer. The fruits of this plant are also used for flavoring and as an aromatizer in the food and beverage industry. This study was done to evaluate the gastric anti-ulcer capacity of this plant in an animal model.

Materials and Methods:

Male Wistar rats were used and the gastric ulcer was induced by oral administration of indomethacin (30 mg/kg, p.o.). The ulcer-bearing rats were orally treated with hydroalcoholic extracts of the leaf (HLE) and fruit (HFE) of hops at similar doses of 50, 100, and 150 mg/kg. Ranitidine (35 mg/kg, p.o.) was used as a reference drug. Gastric acid, pepsin activity, malondialdehyde (MDA), and myeloperoxidase (MPO) were evaluated in gastric tissue, whereas this tissue was examined macroscopically and microscopically.

Results:

The results showed that both extracts (HLE and HFE) at a dose of 150 mg/kg reduced gastric ulcer characteristics such as number and severity, content acidity, pepsin activity, MPO, and MDA values. Also, macroscopic and microscopic images confirmed the effectiveness of the tested extracts in the healing of gastric ulcers.

Conclusion:

It was concluded that leaves and fruits of hops were effective in healing gastric ulcers caused by indomethacin probably by reducing gastric acid and oxidative stress, and this effect was dose-dependent. This effect along with the sedative and anti-Helicobacter pylori properties of hops can be useful in introducing this plant as an antigastric ulcer agent under clinical conditions.
Prediction of Cocrystal Formation Between Drug and Coformer by Simple Structural Parameters
Authors: Shayanfar Shadi , Jouyban Abolghasem , Velaga Sitaram , Shayanfar Ali
Published: December 2022

Background:

Cocrystal formation between an active pharmaceutical ingredient (API) and coformer is an applicable technique to change the physicochemical and pharmacokinetic properties. Computational methods can overcome the need for extensive experiments and improve the chances of success in the coformer selection. In this method, two compounds connect by non-covalent interactions that form a unique crystalline structure. Prediction of a cocrystal formation between API and coformer can help in the screening and design of new cocrystals.

Methods:

In this study, available data in the literature were applied to develop a prediction method based on binary logistic regression to screen cocrystal formation by sum and absolute difference of structural parameters (the number of rotatable bonds, Abraham solvation parameters, and topological polar surface area) of the two involved compounds.

Results:

The results showed various factors (eight structural parameters of the two compounds) could affect cocrystal formation, and the developed model can predict cocrystallization with a probability of about 90%.

Conclusion:

The related parameter to hydrogen bonding basicity and volume of compounds has the most significant effect on cocrystal formation.
Does Resveratrol Enhance Recovery from Acute Ischemic Stroke? A Randomized, Double-blinded, Placebo-controlled Trial
Authors: Sariaslani Payam , Asgharzadeh Sajedeh , Mohammadi Hiwa , Ghanbari Ali , Hezarkhani Leila A. , Shahbazi Foroud , Mirzaeei Shahla
Published: December 2022

Introduction:

Animal studies indicated the protective effect of resveratrol against cerebral ischemic damages, but it has not been researched well in human ischemic stroke. In the present study, the effect of resveratrol on recovery outcomes after acute ischemic stroke was investigated among patients with ischemic stroke who were not eligible for taking recombinant tissue plasminogen activator as an accepted intervention for stroke condition.

Materials and Methods:

In this double-blind clinical trial, 100 patients with ischemic stroke who suffered from the territory of the middle cerebral artery were randomly allocated to either resveratrol or placebo group. In the intervention group, resveratrol was administered orally at a dose of 500 ± 10 mg daily in three 170 mg divided doses, whereas the placebo group was treated with lactose, both for 30 consequent days. Systolic and diastolic blood pressures and the National Institute of Health Stroke Scale (NIHSS) were measured at the stroke onset and during discharges. Besides, the Barthel index and Modified Rankin Scale (MRS) were performed 3 months after the intervention.

Results:

Resveratrol had no significant effects on NIHSS (P = 0.97), systolic (P = 0.17), and diastolic blood pressure (P = 0.42) compared with placebo. There were no significant differences in the Barthel index (P = 0.84) and MRS (P = 1.00) between the two groups 3 months after treatment.

Conclusion:

Resveratrol did not improve functional recovery measured by the NIHSS, MRS, and Barthel index in patients with acute ischemic stroke. In addition, it had no significant effect on blood pressure.
Progress of artificial intelligence in imaging for the diagnosis of drug-resistant pulmonary tuberculosis
Authors: Jiang Fengli , Wang Yu , Xu Chuanjun , Xu Qiuzhen
Published: December 2022

Recent technical advances have led to the application of artificial intelligence in many areas of medical science. This approach was applied early on to medical imaging, which involves a large amount of data for diagnosis. The application of artificial intelligence and imaging diagnostics for disease screening, diagnosis, and prognosis prediction is an area of active research. Early diagnosis and effective management of drug-resistant pulmonary tuberculosis (TB) can effectively control the spread of Mycobacterium TB, reduce hospitalization, and improve prognosis. We review the progress of artificial intelligence in assisting imaging-based diagnosis of this disease, and we offer useful perspectives on future research in this area.
Managing acute pancreatitis pain with bilateral erector spinae plane catheters in a patient allergic to opioids and NSAIDS
Authors: Das Samaresh , Chatterjee Nilay , Mitra Subhro
Published: December 2022

Acute pancreatitis is one of the major causes of abdominal pain and is mainly related to either gallstone or heavy alcohol intake. We have managed a patient with acute pancreatitis with a bilateral erector spinae catheter because he was not suitable for other analgesics. A 72-year-old male with a known alcoholic patient was admitted with severe acute pancreatitis. He also had the chronic obstructive pulmonary disease (COPD) and oesophageal reflux disease. He was allergic to nonsteroidal anti-inflammatory medications and opioids. Therefore, his pain was managed successfully with bilateral erector spinae block with a continuous infusion with 0.125% levobupivacaine 1 ml/hr background infusion and 30 ml every 4 hours using a CADD Solis regional analgesia pump. Although erector spinae block is relatively new and to date, the optimal dose is not determined. We inserted the catheters at the T8 level; however, further study is needed to determine the ideal insertion site and drug volumes. We have mentioned key features, techniques, and management plans and reviewed the latest literature in this case report.
The lumbar subcutaneous fat gradient in spinal anesthesia seen for morbidly obese patient with pre-procedure ultrasonography – A case report
Authors: Nakamura Hiroki , Hisago Shuhei , Ishitsuka Shunsuke
Published: December 2022

It has been reported that pre-procedure ultrasonography rises the success rate of spinal anesthesia in obese patients. In this article, we performed spinal anesthesia for morbidly obese patient with pre-procedure ultrasonography. And recognizing the lumbar subcutaneous fat gradient in morbidly obese patient was the key to success. A cesarean section was scheduled for a primigravida in her 30 s with BMI 61 kg/m2. The lumbar spine was not palpable. Pre-procedure ultrasonography revealed lumbar subcutaneous tissue getting thicker caudally in the sagittal view. Considering this fact, we adjusted the puncture site and succeeded. Postoperative complications were not observed. The pre-procedure ultrasonography is effective even in morbidly obese patients. It is important to recognize the lumbar subcutaneous fat gradient, the so-called back fat slope, for spinal anesthesia in obese patients.
Incidence of IgA antibodies specific to benzo[a]pyrene and steroid hormones in women with colorectal cancer and breast cancer
Authors: Averianov Anton V. , Antonov Alexander V. , Zhivotovskiy Alexey S. , Kostyanko Mikhail V. , Vafin Ilgiz A. , Kolpinskiy Gleb I. , Glushkov Andrey N.
Published: December 2022

Formation of DNA adducts of chemical carcinogens is a trigger for carcinogenesis. Adducts of benzo[a]pyrene metabolites and estradiol metabolites with DNA have been found in normal and tumor cells in healthy women and patients with breast and colorectal cancer. These low-weight compounds in macromolecular complexes induce the synthesis of specific antibodies. Previously, the presence of specific antibodies against benzo[a]pyrene (IgA-Bp), estradiol (IgA-Es) and progesterone (IgA-Pg) was revealed in breast cancer patients. The aim of this study is to identify the putative features of the IgA-Bp, IgA-Es, and IgA-Pg formation in postmenopausal women with colorectal cancer, in comparison with healthy and breast cancer patients. Using a noncompetitive enzyme-linked immunosorbent assay, the content of these antibodies was studied in the blood serum of healthy women (n = 401), patients with colorectal cancer (n = 219) and breast cancer (n = 1469) using conjugates of Bp, Es, and Pg with bovine serum albumin as adsorbed antigens. When compared with healthy people, the patients with colorectal cancer exhibited higher incidence of IgA-Bp 3 (75% vs 37%, p 0.0001, OR = 5.0), as well as more common levels of individual antibody ratios: IgA-Bp/IgA-Es 1 (82% vs 41%, p 0.0001, OR = 6.5); IgA-Bp/IgA-Pg 1.5 (77% vs 20%, p 0.0001, OR = 13.4); IgA-Es/IgA-Pg 1 (89% vs 48%, p 0.0001, OR = 8.7). In breast cancer patients, compared with healthy people, high IgA-Bp values ( 3) were more common (45% vs 37%, p 0.004, OR = 1.4), as well as increased IgA-Bp/IgA-Es ratio 1 (57% vs 41%, p 0.0001, OR = 1.9), IgA-Bp/IgA-Pg 1.1 (71% vs 36%, p 0.0001, OR = 4.4) and IgA-Es/IgA-Pg 1.1 (71% vs 41%, p 0.0001, OR = 3.5). In patients with colorectal cancer, compared with patients with breast cancer we have found higher incidence of increased IgA-Bp values ( 3) (75% vs 45%, p 0.0001), IgA-Es 3 (53% vs 39%, p 0, 0001), and of IgA-Pg 2 (52% vs 44%, p = 0.025), as well as IgA-Bp/IgA- Es 1 (82% vs 57%, p 0.0001, OR = 50.8 ); IgA-Bp/IgA-Pg 1.5 (77% vs 49%, p 0.0001); IgA-Es/IgA-Pg 1.1 (85% vs 71%, p 0.0001). The apparently high serum IgA-Bp levels reflect the formation of DNA-Bp adducts at large scale in target cells in colorectal cancer compared with healthy women and breast cancer patients, due to direct exposure of colon epithelium to Bp from food. Immunoassay for IgA-Bp, IgA-Es and IgA-Pg is proposed for assessing individual risk of colorectal cancer in postmenopausal women. The ratios of IgA Bp/IgA-Pg levels 1.5 represent the most informative marker of individual risk for colorectal cancer.
Anticytokine activity of Candida spp. and their ability to produce cytokine-like substances
Authors: Pashinina Olga A. , Pashkova Tatyana M. , Kartashova Olga L. , Morozova Natalya V.
Published: December 2022

Bacteria are known both to exhibit anticytokine activity (ACA), i.e., to secrete extracellular compounds which inactivate / neutralize various cytokines, and to produce cytokine-like substances (CPV) released to the culture medium. At the same time, the ability of Candida to secrete such substances has not been previously studied. The purpose of our study was to determine the presence of ACA and the ability to produce CPV in Candida strains isolated from the reproductive tract of apparently healthy pregnant women.

The experimental series included 26 clinical strains of Candida spp. isolated from vaginal secretions. Isolation and identification of fungal species was based on morphological and biochemical criteria. ACA against IL-4, IL-6, IL-8, IL-10, IL-17A and TNF were detected following 2-hour co-incubation of fungal suspensions with solutions of the distinct cytokines at a ratio of 1:1. Determination of the cytokine concentrations was carried out by ELISA using the Cytokin kits (St. Petersburg). ACA amounts were defined as the percentage of cytokine inactivation in experimental samples compared to the control expressed as pg/mL. Their ability to produce CPV was expressed as percentage of cytokine production in experimental specimens compared to the controls (pg/mL). The obtained data were subjected to statistical evaluation.

ACA of Candida spp. and their ability to produce CPV were revealed for the first time. with appropriate differences established between the studied Candida species, i.e., cultures of C. non-albicans showed ACA more often for the pro-inflammatory cytokines; C. albicans isolates showed more frequent production of the substances, similar to the pro-inflammatory cytokines IL-8, IL-17A, and TNF. Expression of ACA against IL-10 and ability to produce the anti-inflammatory IL-4- and IL-10-like substances were significantly higher in the cultures of C. non-albicans species.

The results of these experiments expand our knowledge on the spectrum of Candida biological activities and require further study.
Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1
Authors: YUMRUTAŞ Önder , YUMRUTAŞ Pınar
Published: December 2022

One of the most important challenges in the fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by the ABCB1 gene in many organs, is one of the important factors involved in the development of drug resistance. P-gp is mainly involved in efflux of toxic substances such as xenobiotics from the cell. In addition to these, it also plays a role the efflux of drugs used in the treatment of cancer, the rate of success in cancer treatment reduces. Phenolic compounds are chemicals that are naturally synthesized in plants and have many biological activities, especially antioxidant and anticancer. In previous studies, it was determined that in addition to their anticancer activities, phenolics modulate the acquired drug resistance by inhibiting the expression and function of P-gp. In this review, phenolic compounds that play a role in breaking multi-drug resistance by inhibiting the activation and expression of P-gp are discussed.
PENGARUH PENGGUNAAN MEDIA CAMTASIA TERHADAP HASIL BELAJAR MATEMATIKA DI SDN 2 TROSO JEPARA
Authors: Kharissatun Felinna , Widiyono Aan
Published: December 2022

Abstract: The purpose of this study was to determine the effect of using Camtasia videos on mathematics learning outcomes at SDN 2 Troso Jepara in the 2020/2021 academic year. The method used is quantitative research with a quasi-experimental type one group pretest-posttest design. The sample of this study amounted to 38 students of class V SDN 2 Troso Jepara. The test data for learning outcomes is in the form of multiple choice with a total of 25 questions. Analysis of the data used is kolmogorof-Smirnov and t-test. The use of Camtasia media shows that there is a significant difference in student learning outcomes between the pretest and posttest in mathematics problem solving materials. Judging from the mean value of the pretest of students was 56.74, while the mean value of the posttest was 77.79. The increase in the pretest and posttest scores was 21.05. The results of this analysis can be concluded that the use of camtasia media is very effective because it can improve mathematics learning outcomes.Keywords: camtasia media, mathematics, learning outcomes Abstrak: Tujuan dari penelitian ini yaitu mengetahui pengaruh dari penggunaan video camtasia terhadap hasil belajar matematika di  SDN 2 Troso Jepara tahun ajaran 2020/2021. Metode yang digunakan yaitu penelitian kuantitatif dengan jenis quasi eksperimen tipe one grup pretest-posttest design. Sampel penelitian ini berjumlah 38 siswa kelas V SDN 2 Troso Jepara. Data tes hasil belajar berbentuk multiple choice sejumlah 25 soal. Analisis data yang digunakan adalah kolmogorof-smirnov dan uji-t. Dengan penggunaan media camtasia menunjukkan bahwa terdapat perbedaan nyata tentang hasil belajar siswa antara pretest dan posttest pada materi materi pemecahan masalah matematika. Dilihat dari nilai rerata pretest siswa sebesar 56,74 sedangkan, nilai rerata posttest sebesar 77,79. Kenaikan nilai pretest dan posttest sebesar 21,05. Hasil analisis ini dapat disimpulkan bahwa penggunaan media camtasia sangat efektif digunakan karena dapat meningkatkan hasil belajar matematika.Kata Kunci: media camtasia, matematika, hasil belajar
PENINGKATAN KOMPETENSI PEDAGOGIK GURU DALAM PROSES BELAJAR MENGAJAR SEKOLAH DASAR DI KABUPATEN MELAWI
Authors: Waridah Waridah , Tirsa Aprima
Published: December 2022

The purpose of the study was to describe teacher pedagogic competence, improvement efforts, and identify factors that influence efforts to improve teacher pedagogic competence in the teaching and learning process in elementary schools in Melawi Regency. The type of research used qualitative descriptive research is that researchers observe and interact through interview activities. Data analysis by: data reduction, data presentation (data display), and drawing conclusions (verification). The results of the study that the pedagogical competence of teachers can be seen from the ability to understand students, make learning plans, carry out learning, evaluate learning outcomes, and develop students to actualize their various potentials properly. Efforts to improve pedagogic competence are by attending, training, training, upgrading, workshops, seminars / discussions, supervision, and regular meetings. The factors that influence efforts to improve the pedagogical competence of teachers are: educational background, teaching experience, state of health, state of well-being, educational facilities, work discipline in schools, and supervision of the principal.
History of falls, mild cognitive impairment, and the presence of home environmental hazards among community-dwelling older persons in District V, Manila
Authors: Raval Marilou , Lipardo Donald
Published: December 2022

Introduction: It is important to investigate factors that may increase the fall risk in the geriatric population. This study aimed to determine the relationship between: 1) mild cognitive impairments (MCI) and history of falls; 2) home environmental hazards (HEH) and history of falls; and 3) MCI and HEHs among older adults.

Methods: Community-dwelling older persons of District V, Manila were random sampled to participate in this cross-sectional correlational study. The Home Falls and Accidents Screening Tool for Health Professionals (HOMEFAST-HP) and Fall History Questionnaire were used to collect information on the presence of HEH and history of falls, respectively. Chi-Square test was used to determine the relationships between variables.

Results: Thirty-seven (37) older adults, with a mean age of 69.8 + 8.1 years (range = 60-95), 84% female, participated. Majority (78.4%) have MCI. Seven (18.9%) have a history of falls. However, no significant association (p=0.12) exists between MCI and history of falls. About 68.2% of fallers were noted to have HEH, with improper bed (p=.04), inaccessible kitchen items (p=.02) and unidentifiable step edges (pp=.04) and improper bed (p=.01) as HEH reached significant association with MCI.

Discussion: In this study, MCI is not associated with the history of falls. HEH are more common in MCI and fallers, particularly the inaccessible kitchen items, improper bed, loose mats, and unidentifiable edges of steps. Home modifications to address these identified HEH may decrease the fall risk of Filipino older adults with and without MCI. Further investigation using a bigger sample size across different dwelling situations should be considered.
Arnis-based Exercise Program for Balance Control in Community-Dwelling Older Adults: Study Protocol for a Pilot Randomized Controlled Trial
Authors: Lipardo Donald , Manlapaz Donald , Orpilla Vergel , Arevalo Jasneer Tricia , Buan Jim Carlo , Cortez Jaisen Lluch , Desquitado Kyrell Patrick , Geli Vianca Mae , Lacorte Jose Raphael , Masibay Johna , Sanchez Caitlin Joy , Villanueva Alyssa Denise
Published: December 2022

Background: Aging causes impairment in balance and increases the prevalence of falls in older adults. Martial arts are now incorporated into exercise programs to improve balance. Arnis, a Filipino Martial Art, can improve the balance control of older adults.

Objectives: This study primarily aims to determine the effects of an Arnis-based exercise program on balance control of healthy community-dwelling older adults. This study also aims to describe its effect on older adults’ concerns about falling and lower limb functional strength.

Methods: This will be a single-blind, pilot randomized controlled trial. Participants will be randomly allocated to either the intervention or control group. The intervention group will perform an Arnis-based exercise program for 40-60 minutes per session thrice a week for 12 weeks. The control group will continue to do their usual activities for the duration of the study. Participants will be measured at baseline and 12 weeks after for balance, concern for falling, and lower limb strength using the Berg Balance Scale, Timed-Up and Go Test, Falls Efficacy Scale-International Filipino, and the 30-second Chair Sit-to-stand Test, respectively. Data will be analysed through independent and paired t-tests. A p-value

Expected Results: Significant improvements in the balance scores in the intervention group are expected after 12 weeks of the Arnis-based exercise program, along with its effects on concerns for falling and lower extremity strength. The pilot study will provide data on the effectiveness of Arnis as a reference for future larger experimental studies.
Filipino physical therapists’ practice and perspectives on non-treatment physical activity for older adults
Authors: Lunar Frances Rom , Alog Attilah Mae , Tanchuling Alexa , Andal Kristen Mari , Chan Beatrice Camille , Chua Daniel , Martinez Claire Beatrice , Orlino Ma. Anna Carmina , Tan Jem Bettina , Katakura Koji , Ignacio Marvin Louie
Published: December 2022

Introduction: Studies have already investigated the practice of physical therapists (PTs) in promoting non-treatment physical activity (NTPA). However, these were done in the context of mostly western settings or were not specific to older adult practice. It is still unclear if a similar level of practice and perspectives on NTPA promotion exists in a setting where physical therapy is more associated with rehabilitation than health promotion, such as in the Philippines. Therefore, this study aimed to describe Filipino PTs' knowledge of WHO physical activity (PA) guidelines and their use of behavioral change techniques (BCTs) and theories when promoting PA in older adults. It also explored factors that potentially influenced their engagement in PA promotion.

Methods: Filipino PTs who were handling or interested in handling older adult clients from March to April 2020 answered an online/printed survey.

Results: More than half of 72 respondents were unaware (59.72%) and most were unable to recall the WHO guidelines (98.61%) correctly. Respondents used a limited range of BCTs when promoting PA. While some (66.66%) were aware of at least one behavior change theory, a number were unfamiliar with all (33.33%) and only a small proportion reported regular use in practice. A number of factors and respondent characteristics were found to have a statistically significant positive relationship with PA promotion.

Discussion: Study results can serve as preliminary basis for programs that improve promotion of NTPA on older-adult clients by Filipino PTs, specifically regarding knowledge on WHO PA guidelines and their use of a wide range of BCTs and theories. This can potentially place them at the forefront of addressing this health concern in the aging population.
Apresentação do Dossiê | Trajetórias nas universidades: Experiências da lei de cotas, transformações políticas e epistemológicas
Authors: Mainardi Camila , Quintiliano Marta , Da Silva Costa Jacqueline
Published: December 2022

A Revista Desenvolvimento Social (RDS) apresenta, nesta edição, o Dossiê temático "Trajetórias nas universidades: Experiências da lei de cotas, transformações políticas e epistemológicas", organizado por Camila Mainardi (UFG), Marta Quintiliano (UFG) e Jacqueline da Silva Costa (UNILAB).
Autobiografia: Uma trajetória acadêmica kaiowá e guarani
Authors: Benites Antonio Carlos
Published: December 2022

Neste texto descrevo minha trajetória acadêmica de formação nos dois caminhos, na universidade e nos conhecimentos indígenas kaiowá e guarani. Na universidade estive em dois cursos de formação de professores. Cursei pedagogia em uma faculdade particular e conclui a Licenciatura Intercultural Indígena na Universidade Federal da Grande Dourados. Mostro as diferenças entre as duas graduações a partir de minha trajetória e da formação contínua do ser aprendiz da escola xamânica dos indígenas tavyterã/kaiowá e guarani, experiência valorizada na Licenciatura Intercultural e no mestrado em Antropologia Social. Ao final, trato das monografias de outros pesquisadores kaiowá que já passaram pelo ritual da academia. Cada um teve a sua própria trajetória, diferente uns dos outros, e seu modo de produzir na academia. Eu também entro nesse grupo de pesquisadores indígenas e continuo a caminhada de ser o aprendiz dos saberes de coletivos de sábios e sábias kaiowá e guarani.
A compact antenna design for UWB MIMO applications
Authors: Hernández-Serrano ría del Carmen , Carbajal-Gasca Alin Denis , Iturri-Hinojosa Luis Alejandro
Published: December 2022

A compact UWB-MIMO antenna design with an impedance bandwith from 3.2 GHz to 9.1 GHz is presented. The MIMO antenna has a transmission coefficient response less than -14 dB at the resonance frequency bandwidth. To improve the isolation and the antenna performance, an Electromagnetic Band Gap (EBG) structure is introduced between elements, that consists of an added microstrip at ground plane, a 9x1 periodic metal-square patches on top of the substrate, and vertical vias connecting the patches to the ground plane. The EBG structure design methodology is presented. The isolation enhancement between elements is 4 dB at frequency bandwidth. The compact UWB-MIMO antenna with EBG structure reaches a maximum isolation of -33 dB at 6.42 GHz. The peak gain is 4.8 dBi at 7.3 GHz in the H-plane radiation, and 3.3 dBi at 7.3 GHz in the E-plane radiation.
Contra el “privilegio” de quedarse calladas
Authors: Salinas Boldo Claudia
Published: December 2022

El presente trabajo, tiene el objetivo de presentar una reflexión de la forma en la que el reconocimiento y vivencia de la bisexualidad, atraviesa la identidad de mujeres jóvenes latinoamericanas y feministas, a través del análisis de videos de cuatro foros virtuales, en los que estas mujeres hablan de su vivencia como “bisexualas”, forma en la que ellas han decidido identificarse. Para lograr este objetivo, se analizó cualitativamente el discurso de dieciséis mujeres bisexuales, participantes de estos foros virtuales, los cuales tuvieron el objetivo de compartir experiencias y colaboraciones artísticas, en torno al tema de la propia bisexualidad. En los discursos de estas mujeres, fue posible identificar las formas en las que la bifobia les ha dificultado el identificarse como bisexuales; lo que para ellas ha significado el hablar de su orientación sexual con otras personas y las formas en las que han elegido resistir al rechazo y la invisibilización. Asimismo, las jóvenes hablaron de la necesidad de contar con espacios propios, desde los cuales contar sus historias, encontrar elementos en común y pronunciarse políticamente, para luchar en contra de la bifobia que todavía existe en la sociedad.
cuerpo evidenciado
Authors: Granda Viñuelas Édel
Published: December 2022

Este artículo pretende ser un acercamiento desde la antropología del cuerpo al contexto judicial y los juicios de agresiones sexuales que tienen lugar en la Audiencia Provincial de Madrid (España). En primer lugar, se trata de reconocer algunos abordajes previos que se han realizado respecto a la violencia sexual. En segundo lugar, se lleva a cabo una pequeña exploración de las formas de representación profesional de la agresión y las subjetividades generadas. A partir de la noción de “gubernamentalidad” foucaultiana analizo las estrategias de acercamiento al fenómeno desde lo discursivo y la teoría de la práctica. La metodología es cualitativa y las técnicas usadas son la observación participante y las entrevistas semiabiertas en profundidad. Algunas hipótesis que rescato son que en los juicios prima la búsqueda de objetividad y la evidencia, así como la fragmentación del cuerpo de la víctima.
Analisis Faktor Yang Berhubungan Dengan Kecemasan Pasien Pre-Kateterisasi Jantung Di Rumah Sakit Panti Rapih Yogyakarta
Authors: Prabandari Anna , Widyastuti Chatarina Setya , Wardani Yulia
Published: December 2022

Salah satu upaya diagnostik dan intervensi pada penyakit kardiovaskuler adalah kateterisasi jantung.  Kateterisasi jantung merupakan tindakan invasif, dan setiap tindakan medis baik invasif maupun tidak tentu menimbulkan berbagai reaksi emosional bagi pasien. Salah satu reaksi tersebut adalah kecemasan yang biasanya terjadi sebelum tindakan medis. Tujuan penelitian adalah mengidentifikasi faktor – faktor yang berhubungan dengan kecemasan pasien pre-kateterisasi jantung di Rumah Sakit Panti Rapih Yogyakarta. Metode penelitian menggunakan kuantitatif deskriptif korelatif dengan pendekatan cross sectional survey. Populasi penelitian: semua pasien SKA (Sindrom Koroner Akut) yang menjalani kateterisasi jantung dari Desember 2020- Maret 2021 di Rumah Sakit Panti Rapih. Sampel penelitian: accidental-purposive sampling sebanyak 25  responden.  Metode pengumpulan data: kuisioner dan lembar observasi. Hasil penelitian :Faktor yang berhubungan dengan kecemasan pasien pre-kateterisasi jantung adalah jenis kelamin dengan p-value = 0,017 dan pengetahuan tentang prosedur dengan p-value = 0,000, yang tidak berhubungan dengan kecemasan pasien pre-kateterisasi jantung: tingkat pendidikan dengan p-value = 0,522, dukungan keluarga dengan p-value = 0,379, pengalaman kateterisasi sebelumnya dengan p-value = 0,100 dan lama menunggu dengan p-value=0,673. Saran: memberikan edukasi adekuat terkait kateterisasi dengan media yang menarik dan untuk peneliti selanjutnya melakukan penelitian serupa dengan metode kualitatif.
The Faktor – Faktor Yang Berhubungan Dengan Kepuasan Pasien Terhadap Pelayanan Keperawatan di Ruang Rawat Inap Rumah Sakit Panti Rapih Yogyakarta
Authors: Purwantiningsih Emiliana Hesti , Oktri Hastuti Agustina Sri , Mahayanti Agnes
Published: December 2022

Latar Belakang : Kepuasan pasien adalah perasaan yang rasakan dan di ungkapkan oleh pasien setelah membandingkan antara harapan dengan  kenyataan  setelah mendapatkan pelayanan. Pelayanan yang berkualitas memberikan dorongan kepada pasien untuk menjalin hubungan kuat dengan rumah sakit. Kepuasan pasien pada akhirnya berpengaruh terhadap kesetiaan pasien pada rumah sakit yang memberikan kualitas yang memuaskan

Tujuan : Mengetahui faktor – faktor yang berhubungan dengan kepuasan terhadap pelayanan keperawatan di ruang rawat inap rumah sakit panti rapih yogyakarta.

Metode : Rancangan penelitian yang digunakan adalah penelitian korelasi dengan menggunakan pendekatan cross sectional. Pengambilan sampling dengan menggunakan purposive sampling. Populasi pada penelitian ini adalah pasien yang dirawat di Rumah Sakit Panti Rapih di ruang Carolus 5, Elisabet 1 dan Elisabet 4, sampel berjumlah 188 responden Pengumpulan data menggunakan alat ukur kuisioner, kemudian data dianalisa dengan menggunkan uji statistic Spearman’rho

Hasil : Terdapat hubungan yang signifikan antara faktor fasilitas, kinerja, pelayanan, suasana dan komunikasi dengan kepuassan pasien dengan nilai p value = 0,000

Simpulan : Terdapat hubungan yang signifikan antara faktor fasilitas, kinerja, pelayanan, suasana dan komunikasi dengan kepuassan pasien dengan nilai p value = 0,000

Saran : Bagi Kepala Bidang Rumah Sakit: membuat perencanaan  untuk pengawasan terhadap pelaksanaan SOP secara berkala, kepada karyawan tentang tindakan keperawatan, agar pasien merasakan kinerja perawat yang professional, untuk perawat pelaksana: Perawat pelaksanan menerapkan SOP (standar operasional prosedur) setiap tindakan keperawatan  secara benar, pada saat pre interaktif khusus dalam komunikasi perkenalan bahwa penting perawat memperkenalkan diri, diberikan pembekalan service excelent kepada karyawan yang baru.Bagi Sekolah Tinggi Ilmu Kesehatan Panti Rapih Faktor – faktor yang berhubungan dengan kepuasan pasien  belum semua di teliti, hasil penelitian ini  bisa digunakan sebagai data awal untuk melakukan penelitian lebih lanjut, dengan metode yang lain dan responden yang lebih banyak.

Kata kunci :  Fasilitas, pelayanan, kinerja, komunikasi, suasana, kepuasan pasien
Faktor-Faktor Yang Berhubungan Dengan Mortalitas Pasien Di Intensive Care Unit Rumah Sakit Panti Rapih Yogyakarta
Authors: Wungo Jefry Ade , Widyastuti Chatarina Setya , Rina Setyan Fransisca Anjar
Published: December 2022

ABSTRAK

 

Latar Belakang: Mortalitas pasien ICU RS Panti Rapih tahun 2020 mencapai 33,25 %. Mortalitas pasien dapat disebabkan oleh sepsis, henti jantung, ARDS,  problem usia lanjut, komorbiditas, VAP dan post operasi. Perawat memiliki peran penting dalam pemantauan berkelanjutan.

Tujuan: Penelitian ini bertujuan mengidentifikasi faktor-faktor yang berhubungan dengan mortalitas pasien ICU RS Panti Rapih Yogyakarta.

Metode: Penelitian ini merupakan penelitian kuantitatif retrospektif case control. Populasi penelitian sebanyak 424 responden, dengan sample penelitian 208 responden diambil secara acak dengan teknik quota sampling. Pengumpulan data dengan lembar observasi rekam medik. Analisis data  univariat menggunakan analisis prosentase dan bivariat menggunakan Chi-Square dan Kolmogorov-Smirnov.

Hasil: Hasil penelitian menunjukkan tidak terdapat hubungan yang signifikan antara usia dengan mortalitas pasien dengan p-value 0,266, terdapat hubungan yang signifikan antara komorbid dengan mortalitas pasien dengan p-value 0,040, terdapat hubungan yang signifikan antara sepsis dengan mortalitas pasien dengan p-value 0,001, terdapat hubungan yang signifikan antara RJP dengan mortalitas pasien dengan p-value 0,000, terdapat hubungan yang signifikan  antara ARDS dengan mortalitas pasien dengan p-value 0,035, terdapat hubungan yang signifikan  antara VAP dengan mortalitas pasien dengan p-value 0,000, terdapat hubungan yang signifikan antara operasi dengan mortalitas pasien dengan p-value 0,012.

Simpulan: Statistik menunjukkan tidak terdapat hubungan yang signifikan antara usia dengan mortalitas, terdapat hubungan yang signifikan antara komorbid, sepsis, resusitasi jantung paru, ARDS, VAP, operasi dengan mortalitas pasien ICU RS Panti Rapih. Perlunya indikator dan kebijakan yang jelas sehubungan dengan kriteria pasien dirawat dan dipindahkan dari ruang ICU atas asas manfaat terapi intensif.

Kata kunci : ICU (Intensive Care Unit), kriteria pasien, Mortalitas