bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins
Authors: Ning Funan , Chen Lvyi , Chen Linlin , Liu Xin , Zhu Yao , Hu Jiayi , Xie Guangjing , Xia Jiaxuan , Shi Kun , Lan Zhou , Wang Ping
Published: July 2021

Polygoni Multiflori Radix Praeparata (ZhiHeShouWu, PMRP) and Acori Tatarinowii Rhizoma (ShiChangPu, ATR) and their traditional combination (PA) are frequently used in traditional Chinese medicine to prevent and treat Alzheimer disease (AD) based on the theory that PMRP tonifies the kidney and ATR dissipates phlegm. However, the components of PA and their mechanisms of action are not known. The present study analyzed the active components of PA, and investigated the protective effect of PA against cognitive impairment induced by scopolamine in mice along with the underlying mechanism.The aqueous extract of PA was analyzed by high-performance liquid chromatography–mass spectrometry (HPLC-MS) and gas chromatography (GC)-MS in order to identify the major components. To evaluate the protective effect of PA against cognitive dysfunction, mice were orally administered PA, PMRP, or ATR for 30 days before treatment with scopolamine. Learning and memory were assessed in mice with the Morris water maze test; neurotransmitter levels in the hippocampus were analyzed by HPLC-MS; and the expression of synapse-related proteins in the hippocampus was detected by western blotting and immunohistochemistry. Eight active compounds in PA and rat plasma were identified by HPLC-MS and GC-MS. Plasma concentrations of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside, emodin, α-asarone, and asarylaldehyde were increased following PA administration; meanwhile, gallic acid, emodin-8-O-β-d-glucopyranoside, β-asarone, and cis-methyl isoeugenol concentrations were similar in rats treated with PA, PMRP, and ATR. In scopolamine-treated mice, PA increased the concentrations of neurotransmitters in the hippocampus, activated the brain-derived neurotrophic factor (BDNF)/extracellular signal-regulated kinase (ERK)/cAMP response element binding protein (CREB) signaling pathway, and increased the expression of p90 ribosomal S6 kinase (p90RSK) and postsynaptic density (PSD)95 proteins. Thus, PA alleviates cognitive deficits by enhancing synaptic-related proteins, suggesting that it has therapeutic potential for the treatment of aging-related diseases such as AD.
Qingda Granule Attenuates Angiotensin II-Induced Blood Pressure and Inhibits Ca2+/ERK Signaling Pathway
Authors: Wu Meizhu , Wu Xiangyan , Cheng Ying , Shen Zhiqing , Chen Xiaoping , Xie Qiurong , Chu Jianfeng , Li Jiapeng , Liu Liya , Wei Lihui , Long Linzi , Cai Qiaoyan , Peng Jun , Shen Aling
Published: July 2021

Objective: As a well-known traditional Chinese medicine formula prescribed by academician Ke-ji Chen, Qingda granule (QDG) lowered the blood pressure of spontaneously hypertensive rats and attenuated hypertensive cardiac remodeling and inflammation. However, its functional role and underlying mechanisms on hypertensive vascular function remain largely unclear. This study aims to assess the effects of QDG treatment on Angiotensin II- (AngII-) induced hypertension and vascular function and explore its underlying mechanisms both in vitro and in vivo.

Methods: In an in vivo study, 25 male C57BL/6 mice were randomly divided into five groups, including Control, AngII, AngII + QDG-L, AngII + QDG-M, and AngII + QDG-H groups (n = 5 for each group). Mice in AngII and AngII + QDG-L/-M/-H groups were infused with AngII (500 ng/kg/min), while in the Control group, they were infused with saline. Mice in AngII + QDG were intragastrically given different concentrations of QDG (0.5725, 1.145, or 2.29 g/kg/day), while in Control and AngII groups, they were intragastrically given equal volumes of double distilled water for 2 weeks. Blood pressure was determined at 0, 1, and 2 weeks of treatment. Ultrasound was used to detect the pulse wave velocity (PWV) and HE staining to detect the pathological change of the abdominal aorta. RNA sequencing (RNA-seq) was performed to identify the differentially expressed transcripts (DETs) and related signaling pathways. IHC was used to detect the expression of p-ERK in the abdominal aorta. Primary isolated rat vascular smooth muscle cells (VSMCs) were used to assess the cellular Ca2+ release and activation of the ERK pathway by confocal microscope and western blotting analysis, respectively.

Results: QDG treatment significantly alleviated the elevated blood pressure, the PWV, and the thickness of the abdominal aorta in AngII-induced hypertensive mice. RNA-seq and KEGG analyses identified 1,505 DETs and multiple enriched pathways (including vascular contraction and calcium signaling pathway) after QDG treatment. Furthermore, confocal microscope showed that QDG treatment partially attenuated the increase of Ca2+ release with the stimulation of AngII in cultured VSMCs. In addition, IHC and western blotting indicated that QDG treatment also partially alleviated the increase of phospho-ERK levels in abdominal aorta tissues of mice and cultured VSMCs after the infusion or stimulation of AngII.

Conclusion: QDG treatment attenuated the elevation of blood pressure, abdominal aorta dysfunction, pathological changes, Ca2+ release, and activation of the ERK signaling pathway.
The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition
Authors: Chen Chaolu , Zhu Shuaiying , Bai Long , Sui Meihua , Chen Danqing
Published: July 2021

Parturition involves the transformation of the quiescent myometrium into a highly excitable and contractile state, a process that is driven by changes in myometrial gene expression. This study aimed to identify myometrial transcriptomic signatures and potential novel hub genes in parturition, which have great significance for understanding the underlying mechanisms of successful parturition and treating labor-associated pathologies such as preterm birth. In our study, comparative transcriptome analysis was carried out on human myometrial tissues collected from women undergoing caesarean section at term in the presence (TL = 8) and absence of labor (TNL = 8). A total of 582 differentially expressed genes (DEGs) between TL and TNL tissues were identified. Gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG) and gene set enrichment analysis (GSEA) revealed that the DEGs were enriched in signal transduction, regulation of signaling receptor activity, inflammatory response, cytokine-cytokine receptor interaction, IL-17 signaling pathway, TNF signaling pathway, among others. Thus, transcriptome analysis of the myometrium during term labor revealed that labor onset was associated with an inflammatory response. Moreover, protein-protein interactions network analysis identified FPR1, CXCL8, CXCL1, BDKRB2, BDKRB1, and CXCL2 as the hub genes associated with onset of labor. Formyl peptide receptor 1 (FPR1) was highly expressed in laboring myometrial tissues, with the activation of FPR1 in vitro experiments resulting in increased myometrial contraction. Our findings demonstrate the novel role of FPR1 as a modulator of myometrial contraction.
Prescription of Radix Salvia miltiorrhiza in Taiwan: A Population-Based Study Using the National Health Insurance Research Database
Authors: Tseng Ying-Jung , Hung Yu-Chiang , Kuo Chun-En , Chung Chia-Jung , Hsu Chung Y. , Muo Chih-Hsin , Hsu Sheng-Feng , Hu Wen-Long
Published: July 2021

Objective: While radix Salvia miltiorrhiza (Danshen; RSM) is commonly used in Chinese herbal medicine, its current usage has not yet been analyzed in a large-scale survey. This study aimed to investigate the conditions for which RSM is prescribed and the utilization of RSM in Taiwan.

Methods: 1 million beneficiaries enrolled in the Taiwan National Health Insurance Research Database were sampled to identify patients who were prescribed RSM. Next, the diagnoses of these patients based on the International Classification of Diseases 9th Revision Clinical Modification code were analyzed. Logistic regression analysis was employed to estimate the odds ratio (OR) for RSM utilization.

Results: Patients with disorders of menstruation and abnormal bleeding from the female genital tract due to other causes were the diagnostic group most commonly treated with RSM (9.48%), followed by those with general (9.46%) and cardiovascular symptoms (4.18%). Subjects treated with RSM were mostly aged 35–49 years (30.1%). The most common combination of diseases for which RSM was prescribed (0.17%) included menopausal disorders and general symptoms. Women were more likely to receive RSM than men (OR = 1.75, 95% confidence interval = 1.73–1.78). RSM was frequently combined with Yan-Hu-Suo and Jia-Wei-Xiao-Yao-San for clinical use.

Conclusion: To date, this is the first study to identify the most common conditions for which RSM is used in modern Taiwan. The results indicate RSM as a key medicinal herb for the treatment of gynecological diseases, including menstrual disorders, female genital pain, menopausal disorders, etc. The most common combination for which RSM is prescribed is menopausal disorders and general symptoms. Further research is needed to elucidate the optimal dosage, efficacy, and safety of RSM.
Acute Effect of Repeated Sprint Exercise With Blood Flow Restriction During Rest Periods on Muscle Oxygenation
Authors: Kojima Chihiro , Yamaguchi Keiichi , Ito Hiroto , Kasai Nobukazu , Girard Olivier , Goto Kazushige
Published: July 2021

Purpose

This study aimed to examine the effect of applying BFR during rest periods of repeated cycling sprints on muscle oxygenation.

Methods

Seven active males performed 5 × 10-s maximal pedaling efforts with 40-s passive rest, with or without BFR application during rest period. BFR was applied for 30 s between sprints (between 5 and 35 s into rest) through a pneumatic pressure cuff inflated at 140 mmHg. Vastus lateralis muscle oxygenation was monitored using near-infrared spectroscopy. In addition, blood lactate concentration and heart rate were also evaluated.

Results

The BFR trial showed significantly lower oxyhemoglobin (oxy-Hb) and tissue saturation (StO2) levels than the CON trial (P < 0.05). However, power output and blood lactate concentration did not significantly differ between the two trials (P > 0.05).

Conclusion

Applying BFR during rest periods of repeated cycling sprints decreased muscle oxygenation of active musculature, without interfering with power output during sprints.
Reverse Trigger in Ventilated Non-ARDS Patients: A Phenomenon Can Not Be Ignored!
Authors: Lin Zhimin , Zhou Jing , Lin Xiaoling , Wang Yingzhi , Zheng Haichong , Huang Weixiang , Liu Xiaoqing , Li Yimin , Zhong Nanshan , Huang Yongbo , Xu Yuanda , Sang Ling
Published: July 2021

Introduction

The role of reverse trigger (RT) was unknown in ventilated non-acute respiratory distress syndrome (ARDS) patients. So we conducted a retrospective study to evaluate the incidence, characteristics and physiologic consequence of RT in such population.

Method

Six ventilated non-ARDS patients were included, the esophageal balloon catheter were placed for measurements of respiratory mechanics in all patients. And the data were analyzed to identified the occurrence of RT, duration of the entrainment, the entrainment pattern or ratio, the phase difference (dP) and the phase angle (θ), phenotypes, Effects and clinical correlations of RT.

Result

RT was detected in four patients of our series (66.7%), and the occurrence of RT varying from 19 to 88.6% of their recording time in these 4 patients. One patient (No.2) showed a stable 1:1 ratio and Mid-cycle RT was the most common phenotype. However, the remained patients showed a mixed ratios, and Late RT was the most common phenotype, followed by RT with breath stacking. The average values of mean phase delay and phase angles were 0.39s (0.32, 0.98) and 60.52° (49.66, 102.24). Mean phase delay and phase angles were shorter in early reverse triggering with early and delayed relaxation, and longer in mid, late RT and RT with breath stacking. Pmus was variable between patients and phenotypes, and larger Pmus was generated in Early RT, Delayed Relaxation and mid cycle RT. When the RT occurred, the Peso increased 17.27 (4.91, 19.71) cmH2O compared to the controlled breathing, and the average value of incremental ΔPeso varied widely inter and intra patients (Table 3B and Figure 1). Larger ΔPeso was always generated in Early RT, Delayed Relaxation and mid cycle RT, accompanied by an significant increase of PL with 19.12 (0.75) cmH2O and 16.10 (6.23) cmH2O.

Conclusion

RT could also be observed in ventilated non-ARDS patients. The characteristics of pattern and phenotype was similar to RT in ARDS patients to a large extent. And RT appeared to alter lung stress and delivered volumes.
Physiological Effects and Inter-Individual Variability to 12 Weeks of High Intensity-Interval Training and Dietary Energy Restriction in Overweight/Obese Adult Women
Authors: Andrade-Mayorga Omar , Martínez-Maturana Nicolás , Salazar Luis A. , Díaz Erik
Published: July 2021

Background: Human adaptive response to exercise interventions is often described as group average and SD to represent the typical response for most individuals, but studies reporting individual responses to exercise show a wide range of responses.

Objective: To characterize the physiological effects and inter-individual variability on fat mass and other health-related and physical performance outcomes after 12 weeks of high-intensity interval training (HIIT) and dietary energy restriction in overweight/obese adult women.

Methods: Thirty untrained adult overweight and obese women (age = 27.4 ± 7.9 years; BMI = 29.9 ± 3.3 kg/m2) successfully completed a 12-week supervised HIIT program and an individually prescribed home hypocaloric diet (75% of daily energy requirements) throughout the whole intervention. High and low responders to the intervention were those individuals who were able to lose ≥ 10 and < 10% of initial absolute fat mass (i.e., kilograms), respectively.

Results: The prevalence for high and low responders was 33% (n = 11) and 66% (n = 19), respectively. At the whole group level, the intervention was effective to reduce the absolute fat mass (30.9 ± 7.2 vs. 28.5 ± 7.2 kg; p < 0.0001), body fat percentage (39.8 ± 4.3 vs. 37.8 ± 4.9%; p < 0.0001), and total body mass (76.7 ± 10.1 vs. 74.4 ± 9.9 kg; p < 0.0001). In addition, there were improvements in systolic blood pressure (SBP; Δ% = −5.1%), diastolic blood pressure (DBP; Δ% = −6.4%), absolute VO2peak (Δ% = +14.0%), relative VO2peak (Δ% = +13.8%), peak power output (PPO; Δ% = +19.8%), anaerobic threshold (AT; Δ% = +16.7%), maximal ventilation (VE; Δ% = +14.1%), and peak oxygen pulse (O2 pulse; Δ% = +10.4%). However, at the individual level, a wide range of effects were appreciated on all variables, and the magnitude of the fat mass changes did not correlate with baseline body mass or fat mass.

Conclusion: A 12-week supervised HIIT program added to a slight dietary energy restriction effectively improved fat mass, body mass, blood pressure, and cardiorespiratory fitness (CRF). However, a wide range of inter-individual variability was observed in the adaptative response to the intervention. Furthermore, subjects classified as low responders for fat mass reduction could be high responders (HiRes) in many other health-related and physical performance outcomes. Thus, the beneficial effects of exercise in obese and overweight women go further beyond the adaptive response to a single outcome variable such as fat mass or total body mass reduction.
Barley Nepenthesin-Like Aspartic Protease HvNEP-1 Degrades Fusarium Phytase, Impairs Toxin Production, and Suppresses the Fungal Growth
Authors: Bekalu Zelalem Eshetu , Dionisio Giuseppe , Madsen Claus Krogh , Etzerodt Thomas , Fomsgaard Inge S. , Brinch-Pedersen Henrik
Published: July 2021

Nepenthesins are categorized under the subfamily of the nepenthesin-like plant aspartic proteases (PAPs) that form a distinct group of atypical PAPs. This study describes the effect of nepenthesin 1 (HvNEP-1) protease from barley (Hordeum vulgare L.) on fungal histidine acid phosphatase (HAP) phytase activity. Signal peptide lacking HvNEP-1 was expressed in Pichia pastoris and biochemically characterized. Recombinant HvNEP-1 (rHvNEP-1) strongly inhibited the activity of Aspergillus and Fusarium phytases, which are enzymes that release inorganic phosphorous from phytic acid. Moreover, rHvNEP-1 suppressed in vitro fungal growth and strongly reduced the production of mycotoxin, 15-acetyldeoxynivalenol (15-ADON), from Fusarium graminearum. The quantitative PCR analysis of trichothecene biosynthesis genes (TRI) confirmed that rHvNEP-1 strongly repressed the expression of TRI4, TRI5, TRI6, and TRI12 in F. graminearum. The co-incubation of rHvNEP-1 with recombinant F. graminearum (rFgPHY1) and Fusarium culmorum (FcPHY1) phytases induced substantial degradation of both Fusarium phytases, indicating that HvNEP-1-mediated proteolysis of the fungal phytases contributes to the HvNEP-1-based suppression of Fusarium.
Transcriptional Regulation and Signaling of Developmental Programmed Cell Death in Plants
Authors: Jiang Cheng , Wang Jiawei , Leng Hua-Ni , Wang Xiaqin , Liu Yijing , Lu Haiwen , Lu Meng-Zhu , Zhang Jin
Published: July 2021

Developmental programmed cell death (dPCD) has multiple functions in plant growth and development, and is of great value for industrial production. Among them, wood formed by xylem dPCD is one of the most widely used natural materials. Therefore, it is crucial to explore the molecular mechanism of plant dPCD. The dPCD process is tightly regulated by genetic networks and is involved in the transduction of signaling molecules. Several key regulators have been identified in diverse organisms and individual PCD events. However, complex molecular networks controlling plant dPCD remain highly elusive, and the original triggers of this process are still unknown. This review summarizes the recent progress on the transcriptional regulation and signaling of dPCD during vegetative and reproductive development. It is hoped that this review will provide an overall view of the molecular regulation of dPCD in different developmental processes in plants and identify specific mechanisms for regulating these dPCD events. In addition, the application of plants in industrial production can be improved by manipulating dPCD in specific processes, such as xylogenesis.
An in vitro Propagation of Aspilia africana (Pers.) C. D. Adams, and Evaluation of Its Anatomy and Physiology of Acclimatized Plants
Authors: Okello Denis , Yang Sungyu , Komakech Richard , Rahmat Endang , Chung Yuseong , Gang Roggers , Kim Yong-Goo , Omujal Francis , Kang Youngmin
Published: July 2021

Aspilia africana(Pers.) C. D. Adams is an important medicinal plant, that has been used as traditional medicine in many African countries for the treatment of various health problems, including inflammatory conditions, osteoporosis, tuberculosis, cough, measles, diabetes, diarrhea, malaria, and wounds. We developed an efficient and reproducible protocol forin vitroregeneration ofA. africanafrom nodes. We assessed the effects of plant tissue culture media onA. africanagrowth, cytokinins forin vitroshoot regeneration and proliferation, and auxins for the rooting of regenerated shoots. Furthermore, chlorophyll content, photosynthetic rates, anatomy (leaves, stems, and roots), and Fourier transform near-infrared (FT-NIR) spectra (leaves, stems, and roots) of thein vitroregenerated and maternalA. africanaplants were compared. Murashige and Skoog media, containing vitamins fortified with benzylaminopurine (BA, 1.0 mg/l), regenerated the highest number of shoots (13.0 ± 0.424) fromA. africananodal segments. 1-naphthaleneacetic acid (NAA, 0.1 mg/l) produced up to 13.10 ± 0.873 roots, 136.35 ± 4.316 mm length, and was the most efficient for rooting. During acclimatization, thein vitroregeneratedA. africanaplants had a survival rate of 95.7%, displaying normal morphology and growth features.In vitroregenerated and motherA. africanaplants had similar chlorophyll contents, photosynthetic rates, stem and root anatomies, and FT-NIR spectra of the leaf, stem, and roots. The established regeneration protocol could be used for large-scale multiplication of the plant within a short time, thus substantially contributing to its rapid propagation and germplasm preservation, in addition to providing a basis for the domestication of this useful, high-value medicinal plant.
A Qualitative Investigation Into What Parents Want From an Online Behavioural Sleep Intervention for Children With Epilepsy
Authors: Cook Georgia , Gringras Paul , Hiscock Harriet , Pal Deb K. , Wiggs Luci
Published: July 2021

Many of the same sleep problems seen in typically developing (TD) children are frequently experienced by children with epilepsy (CWE). Behavioural sleep interventions (BSIs) are commonly and successfully used to treat these sleep problems in TD children and in some neurodevelopmental disorder populations. Therefore, BSIs should be effective in CWE, however, there are special seizure-related considerations for CWE and their parents which may be salient to consider in any future BSI development for this group. The current study sought to identify, from parents, if there were special considerations for the content and delivery of an online BSI for parents of CWE. Semi-structured interviews were conducted with nine mothers of CWE and thematic analysis was conducted on the interview data. Ten themes were apparent which represented what parents wanted from any online BSI for CWE. Parents wanted (i) other parents’ views and real-life experiences to be included, (ii) recognition of how changes over time may influence the appropriateness of using various sleep-management options, (iii) to be presented with a range of sleep management options from which they could select, (iv) personalised information and suggestions for behaviour-change options, (v) help to address child anxiety around sleep, (vi) for the advice and behaviour-change options to be practical, (vii) general educational information about sleep and the relationship between sleep and epilepsy, (viii) for parental worries and concerns to be acknowledged, (ix) to receive help, support, and reassurance around children’s sleep; and (x) to include the child in the intervention. It was clear that any online BSI would require specific adaptations and additions (to content and delivery format) to best meet the needs of parents of CWE. It is hoped that having identified what parents want from on online BSI for CWE will allow these factors to be acknowledged in future intervention development, with the intention to optimise parental engagement and intervention effectiveness. Practical suggestions for how these aspects could be integrated into any online BSI are suggested.
Does Language Make a Difference? A Study of Language Dominance and Inhibitory Control
Authors: Salwei Ashley Marie , de Diego-Lázaro Beatriz
Published: July 2021

Although extensive research has been done to compare monolingual and bilingual children’s executive function, there are fewer studies that look at the relation between bilingual children’s languages and executive function. The purpose of this study was two-fold; first, to compare inhibitory control (executive function) in monolingual and bilingual children and second, to determine what vocabulary measure (dominant vs. non-dominant language) was related to inhibitory control in bilingual children. Twenty monolingual (English) and 20 bilingual (English-Spanish) children between the ages of 8 and 12 completed a vocabulary test (in English and Spanish) and an inhibitory control task (the flanker task). Analysis of Covariances (ANCOVAs) revealed no significant differences between monolingual and bilingual children in reaction time (RT) or accuracy in the flanker task after controlling for maternal education. Partial correlations controlling for age showed that English expressive vocabulary (dominant language), but not Spanish, was positively correlated with inhibitory control (larger vocabulary and better inhibitory control), suggesting that bilingual children may use their dominant language to self-regulate over their non-dominant language, increasing the inhibitory control associated to the dominant language.
Stability and Change of the Personality Traits Languidity and Flexibility in a Sample of Nurses: A 7–8 Years Follow-Up Study
Authors: Pallesen Ståle , Thun Eirunn , Waage Siri , Vedaa Øystein , Harris Anette , Blytt Kjersti Marie , Kaur Puneet , Bjorvatn Bjørn
Published: July 2021

The traits languidity (tendency to become tired/sleepy upon losing sleep) and flexibility (ability to sleep and work at odd times) have been implicated in shift work tolerance. However, there is a dearth of knowledge about their temporal stability. The aim of the present study was to explore these traits during a long follow-up (FU) period and identify factors related to potential changes in trait scores over time. In all, 1,652 nurses completed the Circadian Type Inventory-revised (CTI-r), which measures languidity and flexibility, at both 2008/2009 (baseline, BL) and again in 2016 (FU). The latent scores of these two constructs at BL, in addition to age, sex, childcare responsibility, marital status, night work status, and insomnia status, were regressed on the corresponding latent scores at follow-up using a structural equation modeling (SEM) approach. Stability was found for both languidity (rho = 0.59) and flexibility (rho = 0.58). Both composite scores declined significantly from baseline (20.62 and 12.48) to follow-up (19.96 and 11.77). Languidity at baseline was positively associated with languidity at follow-up (β = 0.89, p < 0.009). Undertaking childcare responsibility between baseline and follow-up was inversely related to languidity at follow-up (β = −0.09, p < 0.05). Starting night work was positively related to languidity at follow-up (β = 0.06, p < 0.05). Developing insomnia between baseline and follow-up (β = 0.15, p < 0.05) was positively, whereas remitting from insomnia during the same period was negatively (β = −0.11, p < 0.01) associated with languidity at follow-up. Flexibility at baseline was positively associated with flexibility at follow-up (β = 0.64, p < 0.05). Having childcare responsibility at baseline, but not at follow-up was inversely related to flexibility at follow-up (β = −0.05 p < 0.05). Becoming cohabitant with a partner between baseline and follow-up (β = −0.07, p < 0.05) was negatively associated with flexibility at follow-up. Starting night work between baseline and follow-up (β = 0.17, p < 0.01) and reporting night work at both baseline and follow-up (β = 0.18, p < 0.01) were both positively associated with flexibility at follow-up, whereas stopping working nights was negatively (β = −0.09, p < 0.05), associated with flexibility at follow-up. The personality traits languidity and flexibility show fairly high stability, albeit the mean scores were significantly reduced during the 7–8 years follow-up period. The results suggest that these personality traits are partly modifiable.
Early Auditory Event-Related Potentials Are Modulated by Alphabetic Literacy Skills in Logographic Chinese Readers
Authors: Zhang Yubin , Pattamadilok Chotiga , Lau Dustin Kai-Yan , Bakhtiar Mehdi , Yim Long-Ying , Leung Ka-Yui , Zhang Caicai
Published: July 2021

The acquisition of an alphabetic orthography transforms speech processing in the human brain. Behavioral evidence shows that phonological awareness as assessed by meta-phonological tasks like phoneme judgment, is enhanced by alphabetic literacy acquisition. The current study investigates the time-course of the neuro-cognitive operations underlying this enhancement as revealed by event-related potentials (ERPs). Chinese readers with and without proficiency in Jyutping, a Romanization system of Cantonese, were recruited for an auditory onset phoneme judgment task; their behavioral responses and the elicited ERPs were examined. Proficient readers of Jyutping achieved higher response accuracy and exhibited more negative-going ERPs in three early ERP time-windows corresponding to the P1, N1, and P2 components. The phonological mismatch negativity component exhibited sensitivity to both onset and rhyme mismatch in the speech stimuli, but it was not modulated by alphabetic literacy skills. The sustained negativity in the P1-N1-P2 time-windows is interpreted as reflecting enhanced phonetic/phonological processing or attentional/awareness modulation associated with alphabetic literacy and phonological awareness skills.
When Social Interaction Backfires: Frequent Social Interaction During the COVID-19 Pandemic Is Associated With Decreased Well-Being and Higher Panic Buying
Authors: Kim Hyunji , Florack Arnd
Published: July 2021

The present research investigated a backfiring effect of social interaction on well-being and general confidence in Western populations during the COVID-19 pandemic. Across two studies, we observed that stronger self-other connectedness and frequent social communication with others during the first few weeks into the quarantine period were associated with worsened well-being and decreased general confidence. In Study 1 (n = 331), we showed that people who reported higher social connectedness and more frequent social interaction experienced declined well-being. In Study 2 (n = 327), we replicated the backfiring effect and showed that those who engaged in frequent social interaction, especially in COVID-19 related conversations, reported decreased general confidence, which mediated the accelerating effect of social interaction on panic buying. Overall, our findings indicated that frequent social interaction under a highly novel and uncertain crisis can relate to negative consequences on mental health and behavior.
Psychometric Analysis of a Postulated Set of Evolved Human Motives
Authors: Aunger Robert , Foster Dugald , Curtis Val
Published: July 2021

Many different general systems of human motives have been postulated in the psychological literature. However, as yet, no consensus on which motives should be nominated, nor how many there are, has emerged. Recently, we deduced the existence of a number of motives using a logical argument derived from evolutionary theory; that humans have evolved an independent psychological “engine” to respond to each kind of evolutionary problem set by a dimension of the human niche, or life-way. Here, we confirm the existence of 14 out of 15 of these postulated motives using factor analysis on a web-based sample of 500 respondents from the UK: Lust, Hunger, Fear, Disgust, Attract, Love, Nurture, Hoard, Create, Affiliate, Status, Justice, Curiosity, and Play. The items which loaded most strongly for each factor confirmed the expected core value of each motive. Comfort did not emerge, perhaps because it is more about satisfying specific physiological requirements than a cluster of activities linked semantically by the concept of attaining “comfort.” We believe this analysis can form the foundation of a scale for use in applied psychological work ranging from personality testing to personnel selection to public health program design.
Cultivation of Entrepreneurial Talents Through Virtual Entrepreneurship Practice in Higher Education Institutions
Authors: An Hengjie , Xu Yuanyuan
Published: July 2021

The purpose is to study the influence of virtual entrepreneurship practice on entrepreneurial talent cultivation and innovation and entrepreneurship education in higher education institutions. First, a questionnaire is designed from three aspects: entrepreneurial awareness, entrepreneurial psychological quality, and entrepreneurial knowledge structure. Afterward, the questionnaire is issued to 200 students from a college in Shaanxi province, and SPSS 25 is chosen to analyze and characterize the virtual entrepreneurship practice education and the innovation and entrepreneurship education in higher education institutions. The results show that among all the subjects, nearly 20% of them do not understand entrepreneurship, nearly 85% of them concern about the risk of entrepreneurship, and nearly 70% of them take a negative attitude toward entrepreneurial failure. Meanwhile, the subjects have not formed an independent view on entrepreneurship, the subjects’ basic entrepreneurial quality is poor, their entrepreneurship awareness is weak, and their entrepreneurial psychological quality is poor. The subjects lack entrepreneurial quality rather than entrepreneurial knowledge. Finally, some suggestions are put forward on education on virtual entrepreneurship practice in higher education institutions from four aspects: improving the external environment of entrepreneurship, improving the entrepreneurship curriculum in higher education institutions, improving the teaching staff, and developing the practice bases for entrepreneurship education. The results provide some ideas about promoting the comprehensive reform of talent training mode in higher education institutions.
Impact of Innovation and Entrepreneurship Education in a University Under Personality Psychology Education Concept on Talent Training and Cultural Diversity of New Entrepreneurs
Authors: Li Mengru , Wang Tingting , Wu Yanhui
Published: July 2021

The purpose of this study was to explore the cultivation of innovation and entrepreneurship of university students as well as its influence on talent training and cultural diversity. First, based on the combination of theoretical analysis and practical investigation, the entrepreneurship of college students and the basic situation of cultural diversity cultivation were discussed. The research objects involve students of different genders, grades, majors, and family backgrounds. Second, the reliability and validity of the scale were tested, and the survey data were analyzed after eliminating the invalid items. It is found that the average score of entrepreneurship of college students is 3.428; the score of innovation spirit dimension is 3.61, which is the highest in the dimensions; the score of forward-looking dimension is 3.25, which is the lowest; and the variance of leadership dimension is the lowest. The variance of the forward-looking dimension is the greatest. According to the analysis of the scores of different types of students, freshmen score lower in innovation dimension and challenge dimension, challenge spirit of female students is slightly higher than that of male students, and the leadership dimension score of science students is higher. Based on the survey results of cultural diversity training in colleges and universities, the average score is 3.343, the scores of course teaching and educational achievement are lower, and the score of cultural activity dimension is the highest. Liberal arts students have higher scores in cultural diversity, and senior students have low scores in cultural diversity cultivation due to the limited time. This study has been considered in a comprehensive manner. It provides a scientific theoretical basis for carrying out innovation and entrepreneurship education as well as cultural or nutritional activities in colleges and universities and thus has a significant practical value.
Motivation and Intention Toward Physical Activity During the COVID-19 Pandemic: Perspectives From Integrated Model of Self-Determination and Planned Behavior Theories
Authors: Jang Dojin , Kim Inwoo , Kwon Sungho
Published: July 2021

Background: In attempts to hinder the spread of the Coronavirus disease 2019 (COVID-19), many countries have continued distancing, isolation, and quarantine measures, which has led to limited opportunity of physical activity. This study provides empirical support for a motivational process behind physical activity during the COVID-19 pandemic by testing the influence of psychosocial variables derived from the integrated model of self-determination theory (SDT) and the theory of planned behavior (TPB).

Methods: A cross-sectional survey was conducted among Korean adults (N = 248). Participants completed the measures of SDT and TPB constructs modified to reflect their participation in physical activity during the COVID-19 pandemic. A sample size of 243 participants was employed, and the integrated model was tested using serial multiple mediation analysis to check the hypothesized relationships.

Results: Findings indicated that in the COVID-19 context, the satisfaction of basic psychological needs positively predicts the level of self-determined motivations for physical activity, which is partially related to the level of social cognitive beliefs and intentions. The findings also demonstrated that attitude toward physical activity during COVID-19 was a major variable explaining the serial multiple relationships between the SDT and TPB constructs. The potential influence of demographics (gender, age, marital status, and past physical activity) was controlled as a covariate, and no significant effects were identified.

Conclusion: The current study identified the psychosocial mechanisms of intention of South Koreans' physical activity during the COVID-19 pandemic, which could be used as an empirical basis for the development of interventions to maintain or strengthen physical activity in unprecedented situations.
Personality Traits in Burning Mouth Syndrome Patients With and Without a History of Depression
Authors: Tu Trang Thi Huyen , Watanabe Motoko , Suga Takayuki , Hong Chaoli , Takao Chihiro , Takenoshita Miho , Motomura Haruhiko , Toyofuku Akira
Published: July 2021

Objectives: So far, the strong link between neuroticism, chronic pain, and depression has been well-documented in literatures. Some suggested that they might share etiological factors, thus resulting in overlapping constructs. However, such effect has never been tested in burning mouth syndrome (BMS) patients, a complex phenomenon influenced by both neuropathic and psychopathological factors. We aim to clarify how personality affects individual's pain and pain-related experiences.

Methods: Two hundred forty-eight patients with BMS provided demographic information and psychiatric history; completed Ten-Item Personality Inventory, a Visual Analog Scale of pain, and McGill Pain Questionnaire; and provided adequate parameters of depressive state, catastrophizing thinking, and central sensitization.

Results: BMS patients with depression history suffered more severe clinical symptoms and scored higher in neuroticism and less in openness and extraversion than did those without psychiatric diagnoses. After age, sex, and duration of pain were controlled, neuroticism in BMS patients with depression correlates with affective dimension of pain. Instead, if psychiatric history is absent, neuroticism correlates with sensory dimension and pain intensity. In both groups, higher neuroticism, unlike other personality facets, contributed to a more severe clinical condition.

Conclusion: Of the five traits, neuroticism appears to be the most crucial dimension associated with the pain symptoms and patient's conditions. This study implies that management of pain must extend beyond solely providing pain-relieving medication and must require a holistic and multidisciplinary approach.
Psychological Interventions for Healthcare Providers With PTSD in Life-Threatening Pandemic: Systematic Review and Meta-Analysis
Authors: Sun Zeyuan , Yu Chuan , Zhou Yue , Liu Zhenmi
Published: July 2021

Objective: This study aims to evaluate the effect of psychological interventions on healthcare providers (HCP) with post-traumatic stress disorder (PTSD) due to their necessary exposure in life-threatening pandemic.

Methods: We performed a systematic research on Medline, Embase, Cochrane Central, PsycInfo, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, ProQuest PTSD Pubs ProQuest Dissertations & Theses Global, and other gray databases by January 2021. Randomized controlled trials involving therapeutic interventions for HCP with PTSD were included. The primary outcome was PTSD symptom severity. Summary standardized mean differences (SMDs) and 95% confidence intervals were estimated using inverse variance meta-analysis with fixed effects. Risks of bias were assessed using Cochrane methods.

Results: Among 773 citations, this review includes six studies, randomizing 810 participants. A meta-analysis of the effect of interventions compared to placebo showed a significant reduction of PTSD symptom severity: Cognitive Behavioral Therapy-Brief (CBT-B) (M = 27.80, 95% CI: 17.12, 38.48), Cognitive Behavioral Therapy-Long (CBT-L) (M = 26.50, 95% CI: 15.75, 37.25), and Mindfulness-Based Stretching and Deep Breathing Exercise (MBX) (M = 17.2, 95% CI: 6.57, 27.83). CBT-L and CBT-B also showed a significant effect on depression severity.

Conclusions: The most effective and feasible treatment option for HCP with PTSD is still unclear, but CBT and MBX have displayed the most significant effects based on current limited evidence. Future research in this area—preferably large robust randomized controlled trials—is much needed.
Management of the Oral Health of Children During the COVID-19 Pandemic in Poland
Authors: Olszewska Aneta , Paszynska Elzbieta , Roszak Magdalena , Czajka-Jakubowska Agata
Published: July 2021

Managing the oral health of children during the time of a health emergency linked to the current COVID-19 pandemic presents specific problems. A high number of non-specific effective infection control protocols are available in dental settings. It is of fundamental importance to implement specific protocols relating to those clinical situations that normally do not represent an emergency but which now fall into that category. The aim of this study was the comparison of data obtained from the Regional National Health Fund (NFZ) relating to the number and the type of procedures in the oral health management of children aged 0–18 years from the Wielkopolska region, with the months of March and April of 2019 being compared with those of the, respective, pandemic period of 2020. The results showed statistical differences in the number of performed procedures when comparing 2019 and 2020; especially in April (n = 53,077 in 2019 but only n = 2,287 in 2020), when lockdown restrictions reached their highest level and when only 30% of the dental clinics for children were open for patients in the Wielkopolska region of Poland. Regarding surgical cases, there were no differences in percentage frequency between April 2019 and 2020 in terms of extractions. However, an increase was observed in abscess incisions (3.5–17.8%) and surgical dressings (1.5–10.07%). There was a decrease in the total number of performed conservative dentistry procedures in April 2020, but temporary fillings in primary and permanent teeth showed a prominent increase: from 6.4% in 2019 to 19.3% in 2020; and 5.8–11.4%, respectively. Pulp treatment and mucosal lesions therapy fall into the dental emergency category during this COVID-19 pandemic. These cases have shown an increase from 3.2% in 2019 to 12.8% in 2020 for pulp treatment, and from 2.3 to 4.3% for the treatment of oral mucosal lesions. As suspected, after the lockdown was implemented, the number of pediatric dental cases were low. Moreover, the analysis revealed differences in the profile of clinical situations that represented the emergency cases and the pandemic treatment protocols. Future implications suggest that dental prophylactic procedures be included in pandemic protocols with even dental services being limited to a form of urgent treatment. New approaches and treatment models should be implemented in the control of the infectious spread of the disease in the management of the oral health of children in this pandemic period.
Exploring Non-Expert Robot Programming Through Crowdsourcing
Authors: van Waveren Sanne , Carter Elizabeth J. , Örnberg Oscar , Leite Iolanda
Published: July 2021

A longstanding barrier to deploying robots in the real world is the ongoing need to author robot behavior. Remote data collection–particularly crowdsourcing—is increasingly receiving interest. In this paper, we make the argument to scale robot programming to the crowd and present an initial investigation of the feasibility of this proposed method. Using an off-the-shelf visual programming interface, non-experts created simple robot programs for two typical robot tasks (navigation and pick-and-place). Each needed four subtasks with an increasing number of programming statements (if statement, while loop, variables) for successful completion of the programs. Initial findings of an online study (N = 279) indicate that non-experts, after minimal instruction, were able to create simple programs using an off-the-shelf visual programming interface. We discuss our findings and identify future avenues for this line of research.
Improving Health Targeted Food Quality of Blackberry: Pear Fruit Synergy Using Lactic Acid Bacterial Fermentation
Authors: Pucel Nicholas , Sarkar Dipayan , Labbe Ronald G. , Khanongnuch Chartchai , Shetty Kalidas
Published: July 2021

Blackberry and pear are rich in human health protective phenolic bioactives with high antioxidant activity. These fruits are relevant dietary targets to counter chronic oxidative stress-linked diseases, such as type 2 diabetes (T2D). Due to high perishability, the human health relevant bioactive qualities of such fruits deteriorate during postharvest storage and processing. By improving stability and bioavailability of nutritionally relevant phenolic bioactives during post-harvest stages, effective integration of blackberry and pear as dietary support strategies can be targeted for T2D benefits. Solutions to bioactive quality loss of fruits can be achieved by advancing bioprocessing strategy integrating compatible fruit synergy and beneficial lactic acid bacteria (LAB) based fermentation. This approach was targeted to enhance high levels of phenolic bioactive-linked health quality of blackberry (Rubus spp.) integrated with pear (Pyrus communis) at a ratio of 30:70, which was optimized previously based on potential synergistic effects. The aim of this study was to recruit beneficial LAB such as Lactobacillus helveticus and Bifidobacterium longum to bioprocess previously optimized blackberry: pear synergies to improve phenolic bioactive-linked T2D benefits. Essential health-targeted food quality during bioprocessing was assessed based on total soluble phenolic content, phenolic compound profile, total antioxidant activity, anti-hyperglycemic property relevant α-amylase and α-glucosidase enzyme inhibitory, and anti-hypertensive relevant angiotensin-I-converting enzyme (ACE) inhibitory activities using in vitro assay models. Additionally, potential inhibitory activity of fermented fruit extracts against pathogenic Helicobacter pylori, the common bacterial ulcer pathogen was also investigated. Overall, improvement in the retention and stability of phenolic bioactive content in 30:70 blackberry: pear combination, as well as in 100% juice of both fruit extracts were observed following fermentation. Furthermore, enhanced antioxidant activity, anti-hyperglycemic property relevant α-glucosidase, and anti-hypertensive property relevant ACE enzyme inhibitory activities were also observed in fermented extracts of 30:70 blackberry: pear synergy. Among the substrates only fermentation of 100% blackberry with LAB resulted in inhibitory activity against H. pylori. These results provide the biochemical rationale to develop blackberry: pear fruit synergy and beneficial LAB-based fermentation to improve T2D relevant health benefits while also potentially improving keeping quality.