bluuebunny/crossref_metadata_2025 huggingface dataset:
Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance
Authors: Gupte Manisha , Tousif Sultan , Lemon Jacob J. , Toro Cora Angelica , Umbarkar Prachi , Lal Hind
Published: February 2022

Obesity-associated metabolic disorders are rising to pandemic proportions; hence, there is an urgent need to identify underlying molecular mechanisms. Glycogen synthase kinase-3 (GSK-3) signaling is highly implicated in metabolic diseases. Furthermore, GSK-3 expression and activity are increased in Type 2 diabetes patients. However, the isoform-specific role of GSK-3 in obesity and glucose intolerance is unclear. Pharmacological GSK-3 inhibitors are not isoform-specific, and tissue-specific genetic models are of limited value to predict the clinical outcome of systemic inhibiion. To overcome these limitations, we created novel mouse models of ROSA26CreERT2-driven, tamoxifen-inducible conditional deletion of GSK-3 that allowed us to delete the gene globally in an isoform-specific and temporal manner. Isoform-specific GSK-3 KOs and littermate controls were subjected to a 16-week high-fat diet (HFD) protocol. On an HFD, GSK-3α KO mice had a significantly lower body weight and modest improvement in glucose tolerance compared to their littermate controls. In contrast, GSK-3β-deletion-mediated improved glucose tolerance was evident much earlier in the timeline and extended up to 12 weeks post-HFD. However, this protective effect weakened after chronic HFD (16 weeks) when GSK-3β KO mice had a significantly higher body weight compared to controls. Importantly, GSK-3β KO mice on a control diet maintained significant improvement in glucose tolerance even after 16 weeks. In summary, our novel mouse models allowed us to delineate the isoform-specific role of GSK-3 in obesity and glucose tolerance. From a translational perspective, our findings underscore the importance of maintaining a healthy weight in patients receiving lithium therapy, which is thought to work by GSK-3 inhibition mechanisms.
Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL
Authors: Hao Qin , Shetty Sreerama , Tucker Torry A. , Idell Steven , Tang Hua
Published: February 2022

Necroptosis, a form of programmed lytic cell death, has emerged as a driving factor in the pathogenesis of acute lung injury (ALI). As ALI is often associated with a cytokine storm, we determined whether pro-inflammatory cytokines modulate the susceptibility of lung cells to necroptosis and which mediators dominate to control necroptosis. In this study, we pretreated/primed mouse primary lung epithelial and endothelial cells with various inflammatory mediators and assessed cell type-dependent responses to different necroptosis inducers and their underlying mechanisms. We found that interferon-γ (IFNγ) as low as 1 ng/mL preferentially promoted necroptosis and accelerated the release of damage-associated molecular patterns from primary alveolar and airway epithelial cells but not lung microvascular endothelial cells. Type-I IFNα was about fifty-fold less effective than IFNγ. Conversely, TNFα or agonists of Toll-like receptor-3 (TLR3), TLR4, TLR7 and TLR9 had a minor effect. The enhanced necroptosis in IFNγ-activated lung epithelial cells was dependent on IFNγ signaling and receptor-interacting protein kinase-3. We further showed that necroptosis effector mixed lineage kinase domain-like protein (MLKL) was predominantly induced by IFNγ, contributing to the enhanced necroptosis in lung epithelial cells. Collectively, our findings indicate that IFNγ is a potent enhancer of lung epithelial cell susceptibility to necroptosis.
Voluntary Wheel Running in Old C57BL/6 Mice Reduces Age-Related Inflammation in the Colon but Not in the Brain
Authors: Ederer Marie-Luise , Günther Madlen , Best Lena , Lindner Julia , Kaleta Christoph , Witte Otto W. , Simon Rowena , Frahm Christiane
Published: February 2022

Inflammation is considered a possible cause of cognitive decline during aging. This study investigates the influence of physical activity and social isolation in old mice on their cognitive functions and inflammation. The Barnes maze task was performed to assess spatial learning and memory in 3, 9, 15, 24, and 28 months old male C57BL/6 mice as well as following voluntary wheel running (VWR) and social isolation (SI) in 20 months old mice. Inflammatory gene expression was analyzed in hippocampal and colonic samples by qPCR. Cognitive decline occurs in mice between 15 and 24 months of age. VWR improved cognitive functions while SI had negative effects. Expression of inflammatory markers changed during aging in the hippocampus (Il1a/Il6/S100b/Iba1/Adgre1/Cd68/Itgam) and colon (Tnf/Il6/Il1ra/P2rx7). VWR attenuates inflammaging specifically in the colon (Ifng/Il10/Ccl2/S100b/Iba1), while SI regulates intestinal Il1b and Gfap. Inflammatory markers in the hippocampus were not altered following VWR and SI. The main finding of our study is that both the hippocampus and colon exhibit an increase in inflammatory markers during aging, and that voluntary wheel running in old age exclusively attenuates intestinal inflammation. Based on the existence of the gut-brain axis, our results extend therapeutic approaches preserving cognitive functions in the elderly to the colon.
The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
Authors: Ortega Miguel A. , Fraile-Martínez Oscar , García-Montero Cielo , Sáez Miguel A. , Álvarez-Mon Miguel Angel , Torres-Carranza Diego , Álvarez-Mon Melchor , Bujan Julia , García-Honduvilla Natalio , Bravo Coral , Guijarro Luis G. , De León-Luis Juan A.
Published: February 2022

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ grows incredibly rapidly during this period, acting as a mastermind behind different fetal and maternal processes. The relevance of the placenta extends far beyond the pregnancy, being crucial for fetal programming before birth. Having integrative knowledge of this maternofetal structure helps significantly in understanding the development of pregnancy either in a proper or pathophysiological context. Thus, the aim of this review is to summarize the main features of the placenta, with a special focus on its early development, cytoarchitecture, immunology, and functions in non-pathological conditions. In contraposition, the role of the placenta is examined in preeclampsia, a worrisome hypertensive disorder of pregnancy, in order to describe the pathophysiological implications of the placenta in this disease. Likewise, dysfunction of the placenta in fetal growth restriction, a major consequence of preeclampsia, is also discussed, emphasizing the potential clinical strategies derived. Finally, the emerging role of the placenta in maternal chronic venous disease either as a causative agent or as a consequence of the disease is equally treated.
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (Oryza sativa L.)
Authors: Zhang Jialiang , Zhu Yanchun , Yu Lijuan , Yang Meng , Zou Xiao , Yin Changxi , Lin Yongjun
Published: February 2022

Rice (Oryza sativa L.) is one of the most important food crops, feeding half of the world’s population. However, rice production is affected by cadmium (Cd) toxicity. Due to an increase in Cd-contaminated soil and rice grains, and the serious harm to human health from Cd, research on Cd uptake, transport and resistance in rice has been widely conducted, and many important advances have been made. Rice plants absorb Cd mainly from soil through roots, which is mediated by Cd absorption-related transporters, including OsNramp5, OsNramp1, OsCd1, OsZIP3, OsHIR1,OsIRT1 and OsIRT2. Cd uptake is affected by soil’s environmental factors, such as the concentrations of Cd and some other ions in soil, soil properties, and other factors can affect the bioavailability of Cd in soil. Then, Cd is transported within rice plants mediated by OsZIP6, OsZIP7, OsLCD, OsHMA2, CAL1, OsCCX2, OsLCT1 and OsMTP1, from roots to shoots and from shoots to grains. To resist Cd toxicity, rice has evolved many resistance strategies, including the deposition of Cd in cell walls, vacuolar Cd sequestration, Cd chelation, antioxidation and Cd efflux. In addition, some unresolved scientific questions surrounding Cd uptake, transport and resistance in rice are proposed for further study.
Regulation of Nucleolar Activity by MYC
Authors: Brown Isabella N. , Lafita-Navarro M. Carmen , Conacci-Sorrell Maralice
Published: February 2022

The nucleolus harbors the machinery necessary to produce new ribosomes which are critical for protein synthesis. Nucleolar size, shape, and density are highly dynamic and can be adjusted to accommodate ribosome biogenesis according to the needs for protein synthesis. In cancer, cells undergo continuous proliferation; therefore, nucleolar activity is elevated due to their high demand for protein synthesis. The transcription factor and universal oncogene MYC promotes nucleolar activity by enhancing the transcription of ribosomal DNA (rDNA) and ribosomal proteins. This review summarizes the importance of nucleolar activity in mammalian cells, MYC’s role in nucleolar regulation in cancer, and discusses how a better understanding (and the potential inhibition) of aberrant nucleolar activity in cancer cells could lead to novel therapeutics.
Upconversion Luminescent Humidity Sensors Based on Lanthanide-Doped MOFs
Authors: Wang Zhuo , Sun Guotao , Chen Jiabo , Xie Yao , Jiang Hong , Sun Lining
Published: February 2022

Lanthanide-doped metal-organic frameworks (Y/Yb/Er-MOF) were synthesized by a low-cost solvothermal method. The obtained Y/Yb/Er-MOF shows the cooperative upconversion luminescence of Yb3+ and upconversion luminescence of Er3+ (Yb3+-sensitized) irradiated by a continuous wave 980 nm laser. In order to explore the potential application of Y/Yb/Er-MOF in relative humidity (RH) sensors, the RH responsiveness of Y/Yb/Er-MOF was investigated by measuring the intensity changes of upconversion luminescence. The Y/Yb/Er-MOF possesses two luminescence centers, in which Yb3+ forms emission at 500 nm through the cooperative luminescence effect, and Er3+ achieves 660 nm emission through excited state absorption and successive energy transfer from Yb3+. Hence, the ratio meter luminescence sensor for RH is constructed based on Y/Yb/Er-MOF. The results show that the response of Y/Yb/Er-MOF to RH presents a linear relationship in the range of 11–95%. The cycle stability of Y/Yb/Er-MOF responses to RH was investigated with the intensity changes of upconversion luminescence, and the recovery ratio was more than 93% each time. Therefore, the Y/Yb/Er-MOF is a humidity-sensitive material with great potential for applications such as humidity sensors.
Chronic Generalized Lymphadenopathy in a Child—Progressive Transformation of Germinal Centers (PTGC)
Authors: Wills Carson , Mercer Katherine , Malysz Jozef , Rivera Galvis Lidys , Gowda Chandrika
Published: February 2022

Background: Enlarged lymph nodes are a common complaint in a Pediatrician’s office. Diagnosis of reactive lymphadenopathy secondary to infectious, inflammatory, immune dysregulation calls for clinical investigation, including a thorough history, physical exam, imaging, and less often, a biopsy of the lymph node. Here we discuss a rare presentation of extensive generalized, chronic, waxing, and waning lymphadenopathy diagnosed as Progressive Transformation of Germinal Centers (PTGC) and the course of illness over eight years follow up period. Discussion: Progressive Transformation of Germinal Centers (PTGC) is considered a benign condition, but extensive recurrent generalized lymphadenopathy in a very young child has not been reported before. This case demonstrates the importance of long-term follow-up and tailoring the diagnostic work-up and management based on new signs and symptoms. Here we focus on the clinical considerations and management of complex presentation of a common clinical finding.
Biopolymers for Surgical Applications
Authors: Bibire Tudor , Yilmaz Onur , Ghiciuc Cristina Mihaela , Bibire Nela , Dănilă Radu
Published: February 2022

Biopolymers have gained significant attention as a class of polymer materials with a wide range of applications, especially in the medical and pharmaceutical field. Due to particular characteristics, such as biocompatibility, biodegradability, non-toxicity, and functionality, they have become promising candidates for various surgical applications, including as bioadhesives, sealants, wound dressings, sutures, drug carriers, coating materials, etc. Recent research shows that further modification of biopolymers by advanced techniques can improve their functionality i.e., antibacterial activity, cell viability, drug-releasing capability, good wet adhesion performance, and good mechanical properties. This mini review aims to provide a brief report on the type of biopolymers and recent developments regarding their use in various surgical applications.
Magnetic Resonance Imaging or Ultrasound in Localized Intermediate- or High-Risk Soft Tissue Tumors of the Extremities (MUSTT): Final Results of a Prospective Comparative Trial
Authors: Bignotti Bianca , Rossi Federica , Signori Alessio , Solari Nicola , Spina Bruno , Martinoli Carlo , Tagliafico Alberto Stefano
Published: February 2022

Objectives: To report final results of the MUSTT trial, which has been designed to independently compare magnetic resonance imaging (MRI) and ultrasound (US) for local recurrences of non-metastatic patients operated for malignant soft tissue tumors (STT). Methods: Magnetic resonance imaging or ultrasound in soft tissue tumors (MUSTT) is a prospective monocentric study recruiting asymptomatic, non-metastatic patients operated on for localized soft tissue sarcomas between 2015 and April. Eligible patients had MRI and physician-performed ultrasound (US) with an independent interpretation of imaging. Outcome measures were compared using ROC analysis and the X2 test. An analysis of all patients was performed on a per-follow-up event basis. Results: A total of n = 51 patients who met the inclusion criteria agreed to participate. Among them, n = 8 were lost to follow-up, n = 6 had US and MRI acquired after a time frame > 7 days and were therefore excluded. Complete data available for 37 patients with 232 MRI and 232 US scan were finally considered (men/women: 18/20; age range, 18–84 years). Recurrences within 5 years occurred in 10/37 patients (27%). ROC analysis comparing US and MRI showed an AUC with 95% confidence intervals of 0.909 (0.832 to 0.981) for US and 0.966 (0.939 to 0.989) for MRI with Prob > X2 = 0. Conclusions: Each of these tests detected local recurrences with suitable accuracy. MRI did not result clearly superior to US in terms of diagnostic accuracy, but US showed some false positive or negative results.
Automatic Left Ventricle Segmentation from Short-Axis Cardiac MRI Images Based on Fully Convolutional Neural Network
Authors: Shaaf Zakarya Farea , Jamil Muhammad Mahadi Abdul , Ambar Radzi , Alattab Ahmed Abdu , Yahya Anwar Ali , Asiri Yousef
Published: February 2022

Background: Left ventricle (LV) segmentation using a cardiac magnetic resonance imaging (MRI) dataset is critical for evaluating global and regional cardiac functions and diagnosing cardiovascular diseases. LV clinical metrics such as LV volume, LV mass and ejection fraction (EF) are frequently extracted based on the LV segmentation from short-axis MRI images. Manual segmentation to assess such functions is tedious and time-consuming for medical experts to diagnose cardiac pathologies. Therefore, a fully automated LV segmentation technique is required to assist medical experts in working more efficiently. Method: This paper proposes a fully convolutional network (FCN) architecture for automatic LV segmentation from short-axis MRI images. Several experiments were conducted in the training phase to compare the performance of the network and the U-Net model with various hyper-parameters, including optimization algorithms, epochs, learning rate, and mini-batch size. In addition, a class weighting method was introduced to avoid having a high imbalance of pixels in the classes of image’s labels since the number of background pixels was significantly higher than the number of LV and myocardium pixels. Furthermore, effective image conversion with pixel normalization was applied to obtain exact features representing target organs (LV and myocardium). The segmentation models were trained and tested on a public dataset, namely the evaluation of myocardial infarction from the delayed-enhancement cardiac MRI (EMIDEC) dataset. Results: The dice metric, Jaccard index, sensitivity, and specificity were used to evaluate the network’s performance, with values of 0.93, 0.87, 0.98, and 0.94, respectively. Based on the experimental results, the proposed network outperforms the standard U-Net model and is an advanced fully automated method in terms of segmentation performance. Conclusion: This proposed method is applicable in clinical practice for doctors to diagnose cardiac diseases from short-axis MRI images.
A CT-Based Radiomic Signature for the Differentiation of Pulmonary Hamartomas from Carcinoid Tumors
Authors: Cangir Ayten Kayi , Orhan Kaan , Kahya Yusuf , Uğurum Yücemen Ayse , Aktürk İslam , Ozakinci Hilal , Gursoy Coruh Aysegul , Dizbay Sak Serpil
Published: February 2022

Radiomics is a new image processing technology developed in recent years. In this study, CT radiomic features are evaluated to differentiate pulmonary hamartomas (PHs) from pulmonary carcinoid tumors (PCTs). A total of 138 patients (78 PCTs and 60 PHs) were evaluated. The Radcloud platform (Huiying Medical Technology Co., Ltd., Beijing, China) was used for managing the data, clinical data, and subsequent radiomics analysis. Two hand-crafted radiomics models are prepared in this study: the first model includes the data regarding all of the patients to differentiate between the groups; the second model includes 78 PCTs and 38 PHs without signs of fat tissue. The separation of the training and validation datasets was performed randomly using an (8:2) ratio and 620 random seeds. The results revealed that the MLP method (RF) was best for PH (AUC = 0.999) and PCT (AUC = 0.999) for the first model (AUC = 0.836), and PC (AUC = 0.836) in the test set for the second model. Radiomics tumor features derived from CT images are useful to differentiate the carcinoid tumors from hamartomas with high accuracy. Radiomics features may be used to differentiate PHs from PCTs with high levels of accuracy, even without the presence of fat on the CT. Advances in knowledge: CT-based radiomic holds great promise for a more accurate preoperative diagnosis of solitary pulmonary nodules (SPNs).
Is Palatal Rugae Pattern a Reliable Tool for Personal Identification following Orthodontic Treatment? A Systematic Review and Meta-Analysis
Authors: Gupta Archana A. , Kheur Supriya , Alshehri Abdulrahman , Awadh Wael , Ahmed Zeeshan Heera , Feroz Shaikh Mohammed Abdul , Khan Samar Saeed , Mushtaq Shazia , Dewan Harisha , Khurshid Zohaib , Varadarajan Saranya , Sujatha Govindarajan , Veeraraghavan Vishnu Priya , Patil Shankargouda
Published: February 2022

Background: To qualitatively and quantitatively review the reliability of palatal rugae as a tool for personal identification following orthodontic treatment. Methods: Cross-sectional retrospective studies assessing the accuracy of matching palatal rugae pattern pre- and post-orthodontic treatment were identified from PubMed and SCOPUS databases. The title and abstract of the articles identified in the search were screened for potential duplicates and relevancy to the topic of interest. The full text of the articles selected in the screening was analyzed using the inclusion and exclusion criteria. Quantitative analysis of the studies representing coherent data in terms of age and treatment choice was performed using RevMan software. Results: Out of 64 screened articles, only 18 articles fulfilled the eligibility criteria and were included in the systematic review. Out of these 18 articles, only 3 studies had data compatible with the quantitative analysis. Significant changes were noted in lateral first rugae in transverse bilateral direction (p = 0.02) and between second and third lateral rugae of the left side in the anteroposterior direction (p = 0.04). Despite the dimensional changes, observers in most studies were able to accurately (>90%) match the palatal rugae pre- and post-orthodontic treatment through visual observation. Conclusion: The accuracy of the visual matching, despite the significant dimensional changes, indicates that morphology could have potentially been the major matching factor. Thus, a combination of dimensional and morphological evaluation of the palatal rugae could potentially increase the accuracy of personal identification.
The Eutopic Endometrium Proteome in Endometriosis Reveals Candidate Markers and Molecular Mechanisms of Physiopathology
Authors: Méar Loren , Com Emmanuelle , Fathallah Khadija , Guillot Laetitia , Lavigne Régis , Guével Blandine , Fauconnier Arnaud , Vialard François , Pineau Charles
Published: February 2022

Endometriosis is a common chronic gynaecological disease causing various symptoms, such as infertility and chronic pain. The gold standard for its diagnosis is still laparoscopy and the biopsy of endometriotic lesions. Here, we aimed to compare the eutopic endometrium from women with or without endometriosis to identify proteins that may be considered as potential biomarker candidates. Eutopic endometrium was collected from patients with endometriosis (n = 4) and women without endometriosis (n = 5) during a laparoscopy surgery during the mid-secretory phase of their menstrual cycle. Total proteins from tissues were extracted and digested before LC-MS-MS analysis. Among the 5301 proteins identified, 543 were differentially expressed and enriched in two specific KEGG pathways: focal adhesion and PI3K/AKT signaling. Integration of our data with a large-scale proteomics dataset allowed us to highlight 11 proteins that share the same trend of dysregulation in eutopic endometrium, regardless of the phase of the menstrual cycle. Our results constitute the first step towards the identification of potential promising endometrial diagnostic biomarkers. They provide new insights into the mechanisms underlying endometriosis and its etiology. Our results await further confirmation on a larger sample cohort.
Advantages and Applications of Total-Body PET Scanning
Authors: Katal Sanaz , Eibschutz Liesl S. , Saboury Babak , Gholamrezanezhad Ali , Alavi Abass
Published: February 2022

Recent studies have focused on the development of total-body PET scanning in a variety of fields such as clinical oncology, cardiology, personalized medicine, drug development and toxicology, and inflammatory/infectious disease. Given its ultrahigh detection sensitivity, enhanced temporal resolution, and long scan range (1940 mm), total-body PET scanning can not only image faster than traditional techniques with less administered radioactivity but also perform total-body dynamic acquisition at a longer delayed time point. These unique characteristics create several opportunities to improve image quality and can provide a deeper understanding regarding disease detection, diagnosis, staging/restaging, response to treatment, and prognostication. By reviewing the advantages of total-body PET scanning and discussing the potential clinical applications for this innovative technology, we can address specific issues encountered in routine clinical practice and ultimately improve patient care.
Characterizing the Reproducibility of Noisy Quantum Circuits
Authors: Dasgupta Samudra , Humble Travis S.
Published: February 2022

The ability of a quantum computer to reproduce or replicate the results of a quantum circuit is a key concern for verifying and validating applications of quantum computing. Statistical variations in circuit outcomes that arise from ill-characterized fluctuations in device noise may lead to computational errors and irreproducible results. While device characterization offers a direct assessment of noise, an outstanding concern is how such metrics bound the reproducibility of a given quantum circuit. Here, we first directly assess the reproducibility of a noisy quantum circuit, in terms of the Hellinger distance between the computational results, and then we show that device characterization offers an analytic bound on the observed variability. We validate the method using an ensemble of single qubit test circuits, executed on a superconducting transmon processor with well-characterized readout and gate error rates. The resulting description for circuit reproducibility, in terms of a composite device parameter, is confirmed to define an upper bound on the observed Hellinger distance, across the variable test circuits. This predictive correlation between circuit outcomes and device characterization offers an efficient method for assessing the reproducibility of noisy quantum circuits.
A Planar Four-Element UWB Antenna Array with Stripline Feeding Network
Authors: Garbaruk Marek
Published: February 2022

This paper proposes a four-element ultrawideband (UWB) planar antenna array with elliptical-shaped radiators and a stripline excitation network designed for the 6–8.5 GHz UWB frequency band allowed in Europe by the European Commission. The designed antenna array has a symmetrical structure in which the radiators are placed along one line in the central conducting layer, arranged between two layers of a dielectric. Radiating elements are fed by the stripline excitation network that provides uniform power distribution. The dimensions of the elliptical radiators’ axes are 14 mm × 16 mm. Two variants of array are proposed. The distance between the radiators’ centers is L = 19 mm for a shorter variant and L = 24 mm for a longer one. The presented antenna array structures have a size of 81 mm × 41 mm and 96 mm × 41 mm. These arrays present a measured gain of 6.4–10.6 dBi for the shorter variant and 8.5–10.8 dBi for the longer one and a fair impedance matching. The measured |S11| is less than −8.7 dB and −9.7 dB for the shorter and longer corresponding variants.
Protective Coatings for Ferritic Stainless Steel Interconnect Materials in High Temperature Solid Oxide Electrolyser Atmospheres
Authors: Mikkola Jyrki , Couturier Karine , Talic Belma , Frangini Stefano , Giacometti Nathalie , Pelissier Nathalie , Sudireddy Bhaskar Reddy , Thomann Olivier
Published: February 2022

Stainless steel interconnect materials used in solid oxide fuel cells and electrolysers need to be coated to improve oxidation resistance and to mitigate Cr-vaporization. This work aimed to explore the optimal steel/coating combinations suitable for use in reversible solid oxide stacks and evaluated (Co,Mn)3O4 spinel, LaFeO3 perovskite, Ce/Co and Y-based coatings, on AISI441 and Crofer 22 APU steels. The coatings were evaluated based on measurements of mass gain and oxide scale thickness after exposure at 700 and 800 °C to fuel side (90 vol.% H2O/10 vol.% H2) and air/oxygen side (pure O2) atmospheres. In pure O2, the most efficient coatings for limiting oxide scale formation and Cr evaporation, compared to the bare steel, were (Co,Mn)3O4 and CeCo on Crofer 22 APU. In 90 vol.% H2O/10 vol.% H2, the Y-based coating showed the largest improvement in oxidation resistance.
Differential Power Processing Converter with an Integrated Transformer and Secondary Switch for Power Generation Optimization of Multiple Photovoltaic Submodules
Authors: Lim Ji-Hoon , Lee Dong-In , Hyeon Ye-Ji , Choi Jae-Hyuk , Youn Han-Shin
Published: February 2022

In recent years, to increase the fuel efficiency of environment-friendly vehicles, a large volume of research is ongoing regarding applying photovoltaic (PV) systems. However, in PV systems, a power imbalance between submodules is common due to shading or pollution, and this degrades the power generation efficiency of the system. To solve this problem, various differential power processing (DPP) converters have been developed. In order to adopt the DPP converter to environment-friendly vehicles, the DPP converter must have a small volume, high efficiency, and high price competitiveness. In this regard, we propose a DPP converter with a single multi-winding transformer by integrating multiple transformers and secondary sides of the conventional flyback DPP converter. Since the proposed DPP converter can be applied to battery balancing circuits as well as photovoltaic systems, the proposed circuit is a valuable converter. In the PV system, the maximum output power of each submodule is 60 W, and the total PV system is 240 W by connecting four submodules in series. To verify the validity of the proposed DPP converter, a prototype with 8 V input and 60 W/30 V output specification was built and tested, and the effectiveness of the proposed converter is supported by the experimental results.
A Review of Chemical Weed Control Practices in Christmas Tree Production in the United States
Authors: Gallina Greta C. , Cregg Bert M. , Patterson Eric L. , Saha Debalina
Published: February 2022

Christmas trees are sensitive to weed competition, especially during establishment. In initial stages of the tree crop, weeds can utilize available soil moisture and trees may succumb to drought stress. In later stages, weeds can even interfere with production practices. Non-chemical weed control methods alone may not provide effective weed control. Chemical weed management strategies involve the use of preemergence and postemergence herbicides at the right timing and application rates. There are many herbicides that are used in Christmas tree production in the United States, and each has specific application guidelines and weed control spectra. Moreover, crop trees vary in tolerance by species and tree age. Growers need to be careful while applying herbicides as many of these chemicals can cause injury to Christmas trees. Repeated application of herbicides with the same mechanism of action has resulted in development of herbicide resistance among several weed species. Managing herbicide resistance has now become an important issue. More research is required on identifying and managing herbicide resistance among weed species in Christmas tree production. Future research needs to focus on herbicide and mulch combinations, herbicide rotations, and tank mixing different herbicides with different mechanisms of actions and how these affect Christmas tree varieties.
Forest Conservation and Restoration Using the Emberger Index: Cork Oak as Study Case
Authors: Vessella Federico , Schirone Bartolomeo
Published: February 2022

The Mediterranean Basin is frequently stricken by huge disasters, and it represents an important biodiversity hotspot. Designing a synthetic approach, which is user-friendly with a low cost, that aims to summarize the main climatic factors that determine vegetation geographical ranges is a strategic solution to plan forest restoration actions and quickly act in cases of urgency. Here, we propose an updated version of the Emberger Index, applied to Quercus suber, an emblematic species of many ecosystems in the Mediterranean. Our investigation couples the latest spatially continuous climatic data, a high-resolution distribution map, and modelling techniques. The results evidence the effective benefits of the updated process, with insights into the optimal climatic requirements of a species within its real spatial domain, including projections for the next decades and the detection of putative refugia. Those outputs were not possible before because of a lack of data covering a certain area. Cork oak revealed an excellent study case, able to highlight the potentiality of Emberger’s approach, and understand the ecological amplitude and vulnerabilities of the target species. If genetic information is available, the Emberger Index can even be applied at the haplotype scale, thus benefitting the applied research. Such an index mirrors the optimal plasticity and physiologic characteristics of a species, supporting the decision makers in selecting the correct plants to use in future reforestation and restoration activities.
Application of Additives in Platycladus orientalis (L.) Franco Tending Shreds Compost in Forest
Authors: Li Xuan , Bo Huijuan , Zhu Jialei , Zhang Jiwei , Hu Jun , Mu Fuyong , Nie Lishui
Published: February 2022

This study aimed to explore the effects of different additives on tending shreds of Platycladus orientalis (L.) Franco. Two different additives (priming 0.2% and common compost 0.2%) combined with C, N, and P adjustment of raw material treatments were tested on the temperature, moisture, EC, pH, lignocellulose degradation rate, nutrient content, and toxicity of compost. Priming made the compost temperature rise rapidly, and the peak temperature of the composting group with priming reached 51 °C. At the end of composting, the moisture in each treatment from high to low was in the order: common compost > priming > C/N, C/P adjustment only > control group. The increase of EC in the treatments with additives was great, and the peak value of EC in the treatment of priming was 1.30 ms·cm−1, which was 3.9 times higher than that of the control group. At the end of composting, the decomposition rate of cellulose in priming compost was 1.7 times higher than that in the control group, and the hemicellulose decomposition rate in the common compost group was 3.2 times higher than that in the control group. By the end of composting, the pH value of the composts in additive treatments was above 7.0, and the pH value of the priming treatment was the highest (7.5). The highest content of organic matter was found in the priming treatment, which was 52%, 1.7 times higher than that in the control group. The total nutrient content (TN + K2O + P2O5) of additive treatments was higher than 5.0%, and the priming treatment was 2.7% higher than that of the control group. By the end of composting, the germination rate and germination index ranged from 88% to 91% and 60% to 81%. Except for the control group, the C/N ratio of other treatments decreased to below 25. Additives can accelerate the decomposition of raw materials, shorten the composting cycle, and improve the quality of composts, and the effect of adding priming is the most significant.
The Relationships of Habitat Conditions, Height Level, and Geographical Position with Fruit and Seed Traits in Populations of Invasive Vine Echinocystis lobata (Cucurbitaceae) in Central and Eastern Europe
Authors: Kostrakiewicz-Gierałt Kinga , Pliszko Artur , Barabasz-Krasny Beata , Bomanowska Anna , Dajdok Zygmunt , Gudžinskas Zigmantas , Kucharczyk Marek , Maćkowiak Łukasz , Majk Jakub , Możdżeń Katarzyna , Podgórska Monika , Rasimavičius Mindaugas , Rewicz Agnieszka , Szczęśniak Ewa , Wójcik Tomasz , Stachurska-Swakoń Alina
Published: February 2022

In climbing plants, fruits can be formed at different heights, depending on the height of external support. However, the effect of height on fruit and seed traits in invasive vines of Cucurbitaceae has not been intensively studied so far. In Europe, Echinocystis lobata, a North American member of Cucurbitaceae, is considered one of the most abundant invasive alien plants spreading in natural riparian forests, thickets, and tall herbs, whereas it is a rare species in urban woodlands. In this study, we tested the variability of selected fruit and seed traits of E. lobata in connection with habitat origin (natural, semi-natural, and anthropogenic), habitat type (using the EUNIS habitat classification), height (the distance between the fruit and the ground), and geographical position. The study was conducted in 2018 in 65 sites located in Latvia, Lithuania, Poland, and Slovakia. In each study site, a random sample of 10 fresh mature fruits of E. lobata was collected from subsequent 0.50 m intervals of height. The length, the width, and the weight of the fresh fruits, as well as the total number of seeds and number of undeveloped seeds per fruit, were examined. Moreover, the well-developed seeds from selected study sites were weighed. The statistical analysis showed the significant effect of habitat origin, habitat type, and height on most of the studied fruit and seed traits. The largest range of height (from 0.00 to 4.00 m) was observed in two types of habitats (F—heathland, scrub, and tundra; and G—woodland, forest, and other wooded land). The total number of seeds per fruit was positively correlated with the length, width, and weight of the fresh fruits. The fruits were a little heavier and bigger in natural habitats located in the northeast of the study area. The distribution of fruits at different heights may contribute to better dispersal of seeds by animals and wind, and may also better protect the seeds from being eaten by granivorous animals. The defence against seed-eating animals is expected to be stronger in semi-natural habitats, as well as on banks and shores of inland surface waters, where the seed production is the highest. The influence of seed traits on seed germination and seedling survival in various habitats and their importance in the invasiveness of E. lobata require further study.
Exploring Chemical Markers Related to the Acceptance and Sensory Profiles of Concentrated Liquid Coffees: An Untargeted Metabolomics Approach
Authors: Quintero Mónica , Santander Maria José , Velásquez Sebastián , Zapata Julián , Cala Mónica P.
Published: February 2022

In this study, we aimed to apply an untargeted LC/QTOF-MS analysis for the identification of compounds that positively and negatively affect the acceptance of coffee beverages from liquid coffee concentrates (CLCs) before and after storage. The metabolomic results were integrated with physicochemical and sensory parameters, such as color, pH, titratable acidity, and oxygen contents, by a bootstrapped version of partial least squares discriminant analysis (PLS-DA) to select and classify the most relevant variables regarding the rejection or acceptance of CLC beverages. The OPLS-DA models for metabolite selection discriminated between the percent sensory acceptance (the Accepted group) and rejection (the Rejected group). Eighty-two molecular features were considered statistically significant. Our data suggest that coffee sample rejection is associated with chlorogenic acid hydrolysis to produce ferulic and quinic acids, consequently generating methoxybenzaldehydes that impact the perceived acidity and aroma. Furthermore, acceptance was correlated with higher global scores and sweetness, as with lactones such as feruloyl-quinolactone, caffeoyl quinolactone, and 4-caffeoyl-1,5-quinolactone, and significant oxygen levels in the headspace.
Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD)
Authors: Magwai Thabo , Xulu Khethelo Richman
Published: February 2022

Physiological genomics plays a crucial role in responding to stressful life events, such as violence and traumatic stress. This exposure to traumatic stress can trigger several physiological pathways, which are associated with genetic variability. Exposure to traumatic stress can result in the development of behavioural and psychiatric disorders, such as aggressive behaviour and anxiety disorders. Several genes play a crucial role in the neurophysiological response to chronic stress and trauma. These essential genes include monoamine oxidase A (MAOA), solute carrier family 6 member 4 (SLC6A4), brain-derived neurotrophic factor (BDNF), catechol-O-methyltransferase (COMT), dopamine receptor 2 and 4 (DRD2 and DRD4), and FK506 binding protein 5 (FKBP5). Genetic variations in several genes have been found to have altered physiological response, which associates with the development of several behavioural traits. Interestingly, previous studies show that there is an interplay between aggressive behaviour and anxiety disorders, which may be associated with physiological genomics structure. The physiological responses are based on genetic architecture and its molecular reaction. Understanding physiological genomics may show underpinnings related to the development of aggressive behaviours and their interaction with anxiety disorders. This review aims to discuss the association between different physiological genes and the development of psychiatric disorders related to aggressive behaviours and anxiety disorders, such as post-traumatic stress disorder.
Geological and Mining Heritage as a Driver of Development: The NE Sector of the Linares-La Carolina District (Southeastern Spain)
Authors: Mendoza Rosendo , Rey Javier , Martínez Julián , Hidalgo Maria Carmen
Published: February 2022

Conservation, rehabilitation and post-valuation of the facilities of old mining districts is considered a valid strategy to revitalize these areas. In this study, the northeastern sector of the Linares-La Carolina mining district was analyzed, integrating geological information with mining to assess its value. The characteristics of the three most emblematic veins (consisting of galena, sphalerite, chalcopyrite, pyrite, quartz, ankerite and calcite) were analyzed, namely El Guindo, Federico and El Sinapismo. In this study, each mining exploitation was evaluated according to their geological context. Currently, old mining operations can only be visited from drainage galleries or from some exploration galleries. However, some of the old mining shafts could be adapted for visitation. On the surface, the remains of the most important extraction shafts and part of the associated facilities are still visible. One can also visit old tailings dumps with a high contents of heavy metals associated with ore concentration plants. The contaminating potential of these wastes is being monitored thanks to control piezometers and sensors installed at different depths within the tailings ponds, which assist in controlling evolution in the latter years. Different localities of special interest from geological, mining and mineralogical points of view are indicated. Therefore, the guided tour described in this work is attractive for tourism and educational purposes.
The Moderating Effect of Resilience on Mental Health Deterioration among COVID-19 Survivors in a Mexican Sample
Authors: Pérez-Gómez Héctor Raúl , González-Díaz Esteban , Herrero Marta , de Santos-Ávila Fabiola , Vázquez-Castellanos José Luis , Juárez-Rodríguez Pedro , Moreno-Jiménez Bernardo , Meda-Lara Rosa Martha
Published: February 2022

Resilience has been reported to be a protective psychological variable of mental health; however, little is known about its role in COVID-19 survivors. Thus, in this study, we aimed to evaluate the levels of depression, anxiety, stress, traumatic impact, and resilience associated with COVID-19, as well as to investigate the role of resilience as a moderating variable. A sample of 253 participants responded to an online survey; all were previously diagnosed with COVID-19 by a nasopharyngeal swab RT-PCR test, were older than 18 years, and signed an informed consent form. Significant negative correlations were found between resilience and the mental health variables. Higher resilience was significantly related to a lower impact of the event, stress, anxiety, and depression when the number of symptoms was low. Only when the duration of COVID-19 was short and resilience levels were medium or high was psychological distress reduced. Moreover, resilience moderated the effects of COVID-19 on mental health, even if a relapse occurred. The results emphasize the need for interdisciplinary interventions aimed at providing COVID-19 patients with psychological and social resources to cope with the disease, as well as with probable relapses.
Can Music Therapy Improve the Quality of Life of Institutionalized Elderly People?
Authors: González-Ojea María José , Domínguez-Lloria Sara , Pino-Juste Margarita
Published: February 2022

Introduction: The current population has new characteristics that require changes to be made in the public health system. In the case of the elderly, the concrete aspects of their health must be known to improve the system, in search of a better quality of life and as much independence as possible. Method: The aim of this study was to verify the efficiency of a music therapy program with institutionalized elderly participants to avoid depressive symptoms and improve social interaction and creativity. This is a group case study that uses a pretest–post-test descriptive design. The program was divided into sixteen sessions, two sessions each week. As inclusion and exclusion criteria, physical dependency and cognitive state were used. Results: The results present an improvement in the physical dimensions of quality of life and an increase in creativity and social interaction. It is recommended that the sessions in the program, aiming to achieve a greater efficiency, are extended because the elderly have very ingrained habits and routines that are very hard to eliminate. Discussion and conclusions: Music therapy, a non-pharmacological and worthwhile treatment, is a therapeutic option with proven benefits. Music therapy has the potential to improve health and quality of life in the elderly and also foster the amelioration of various chronic illnesses, such as depression.
Relationships between Nursing Students’ Skill Mastery, Test Anxiety, Self-Efficacy, and Facial Expressions: A Preliminary Observational Study
Authors: Kim Myoung Soo , Choi Byung Kwan , Uhm Ju-Yeon , Ryu Jung Mi , Kang Min Kyeong , Park Jiwon
Published: February 2022

Test anxiety and self-efficacy significantly influence the mastery of nursing skills. Facial expression recognition tools are central components to recognising these elements. This study investigated the frequent facial expressions conveyed by nursing students and examined the relationships between nursing skill mastery, test anxiety, self-efficacy, and facial expressions in a test-taking situation. Thirty-three second-year nursing students who were attending a university in a Korean metropolitan city participated. Test anxiety, self-efficacy, and facial expressions were collected while the students inserted indwelling catheters. Using Microsoft Azure software, the researchers examined the students’ facial expressions. Negative facial expressions, such as anger, disgust, sadness, and surprise, were more common during the test-taking situation than the practice trial. Fear was positively correlated with anxiety. None of the facial expressions had significant relationships with self-efficacy; however, disgust was positively associated with nursing skill mastery. The facial expressions during the practice and test-taking situations were similar; however, fear and disgust may have been indicators of test anxiety and skill mastery. To create a screening tool for detecting and caring for students’ emotions, further studies should explore students’ facial expressions that were not evaluated in this study.