bluuebunny/crossref_metadata_2025 huggingface dataset:
Vanillic Acid as a Promising Xanthine Oxidase Inhibitor: Extraction from Amomum villosum Lour and Biocompatibility Improvement via Extract Nanoemulsion
Authors: Zhou Qian , Li Xiaoyan , Wang Xiaohui , Shi Dongdong , Zhang Shengao , Yin Yuqi , Zhang Hanlin , Liu Bohao , Song Nannan , Zhang Yinghua
Published: March 2022

Gout is an oxidative stress-related disease. Food-derived vanillic acid, a promising xanthine oxidase inhibitor, could potentially be used as a safe, supportive, and therapeutic product for gout. The extraction of vanillic acid from a classic Chinese herbal plant Amomum villosum with ethanol was investigated in the study. The optimum conditions were determined as extraction time of 74 min, extraction temperature of 48.36 °C, and a solid-to-liquid ratio of 1:35 g·mL−1 using the Box–Behnken design (BBD) of response surface methodology (RSM). The experimental extraction yield of 9.276 mg·g−1 matched with the theoretical value of 9.272 ± 0.011 mg·g−1 predicted by the model. The vanillic acid in Amomum villosum was determined to be 0.5450 mg·g−1 by high-performance liquid chromatography–diode array detection (HPLC–DAD) under the optimum extraction conditions and exhibited xanthine oxidase (XO) inhibitory activity, with the half-maximal inhibitory concentration (IC50) of 1.762 mg·mL−1. The nanoemulsion of Amomum villosum extract consists of 49.97% distilled water, 35.09% Smix (mixture of tween 80 and 95% ethanol with 2:1 ratio), and 14.94% n-octanol, with a particle size of 110.3 ± 1.9 nm. The nanoemulsion of Amomum villosum extract exhibited markable XO inhibitory activity, with an inhibition rate of 58.71%. The result demonstrated the potential benefit of Amomum villosum as an important dietary source of xanthine oxidase inhibitors for gout.
Quantitative Microbial Risk Assessment of Listeria monocytogenes and Enterohemorrhagic Escherichia coli in Yogurt
Authors: Yang So Young , Yoon Ki Sun
Published: March 2022

Listeria monocytogenes can survive in yogurt stored at a refrigeration temperature. Enterohemorrhagic Escherichia coli (EHEC) has a strong acid resistance that can survive in the yogurt with a low pH. We estimated the risk of L. monocytogenes and EHEC due to yogurt consumption with @Risk. Predictive survival models for L. monocytogenes and EHEC in drinking and regular yogurt were developed at 4, 10, 17, 25, and 36 °C, and the survival of both pathogens in yogurt was predicted during distribution and storage at home. The average initial contamination level in drinking and regular yogurt was calculated to be −3.941 log CFU/g and −3.608 log CFU/g, respectively, and the contamination level of both LM and EHEC decreased in yogurt from the market to home. Mean values of the possibility of illness caused by EHEC were higher (drinking: 1.44 × 10−8; regular: 5.09 × 10−9) than L. monocytogenes (drinking: 1.91 × 10−15; regular: 2.87 × 10−16) in the susceptible population. Both pathogens had a positive correlation with the initial contamination level and consumption. These results show that the foodborne illness risk from L. monocytogenes and EHEC due to yogurt consumption is very low. However, controlling the initial contamination level of EHEC during yogurt manufacture should be emphasized.
Topographic Outcomes in Keratoconus Surgery: Epi-on versus Epi-off Iontophoresis Corneal Collagen Cross-Linking
Authors: Napolitano Pasquale , Tranfa Fausto , D’Andrea Luca , Caruso Ciro , Rinaldi Michele , Mazzucco Alberto , Ciampa Nicola , Melenzane Antonietta , Costagliola Ciro
Published: March 2022

Background: Corneal collagen cross-linking (CXL) has become the gold standard for mild and moderate stages to stop the progression of keratoconus. We analyzed some corneal topography indices to compare iontophoresis epi-on and iontophoresis epi-off techniques throughout a two-year follow-up. Methods: A total of 64 eyes of 49 patients who underwent CXL were recruited. In 30 eyes the epi-off technique was performed, whereas the remaining 34 eyes were treated with the epi-on technique. All patients underwent a complete ophthalmologic examination that included CDVA, central and thinnest corneal thickness, Schirmer test I, TBUT test, and the Ocular Surface Disease Index. Results: In both groups, a significant improvement in visual function was recorded. No statistically significant differences between Kmax, Mean K, Flat K, Steep K values were found. Statistically significant differences (p < 0.05) between the epi-on and epi-off groups’ pachymetry before and after 24 months follow-up as well as between the epi-on and epi-off groups’ topographically thinnest point in the immediate post-surgery and 24 months after surgery were recorded. Conclusion: Our study highlighted that both techniques are valid in mid-term corneal stabilization. The advantage of the new iontophoresis epi-off cross-linking technique could be found in a faster imbibing time of the cornea, therefore reducing surgical times, with a lower risk of complications.
Special Issue “New Therapies of Liver Diseases”
Authors: Toniutto Pierluigi
Published: March 2022

Medical and surgical treatments aimed at curing severe liver diseases and prolonging the survival of patients have improved dramatically in recent years [...]
Treatment of Giant Cell Arteritis (GCA)
Authors: Régent Alexis , Mouthon Luc
Published: March 2022

Giant cell arteritis (GCA) is the most frequent primary large-vessel vasculitis in individuals older than 50. Glucocorticoids (GCs) are considered the cornerstone of treatment. GC therapy is usually tapered over months according to clinical symptoms and inflammatory marker levels. Considering the high rate of GC-related adverse events in these older individuals, immunosuppressive treatments and biologic agents have been proposed as add-on therapies. Methotrexate was considered an alternative option, but its clinical impact was limited. Other immunosuppressants failed to demonstrate a significant favourable benefit/risk ratio. The approval of tocilizumab, an anti-interleukin 6 (IL-6) receptor inhibitor brought significant improvement. Indeed, tocilizumab had a noticeable effect on cumulative GCs’ dose and relapse prevention. After the improvement in pathophysiological knowledge, other targeted therapies have been proposed, with anti-IL-12/23, anti-IL-17, anti-IL-1, anti-cytotoxic T-lymphocyte antigen 4, Janus kinase inhibitors or anti-granulocyte/macrophage colony stimulating factor therapies. These therapies are currently under evaluation. Interestingly, mavrilimumab, ustekinumab and, to a lesser extent, abatacept have shown promising results in phase 2 randomised controlled trials. Despite this recent progress, the value, specific condition and optimal application of each treatment remain undecided. In this review, we discuss the scientific rationale for each treatment and the therapeutic strategy.
Comparative Longitudinal Analysis of Malignant Transformation in Pleomorphic Adenoma and Recurrent Pleomorphic Adenoma
Authors: Choi Sung Yong , Choi Jaehyuck , Hwang Inwoo , Cho Junhun , Ko Young-Hyeh , Jeong Han-Sin
Published: March 2022

Background: Recurrence in pleomorphic adenoma (PA) has been debated as a risk factor for malignant transformation (MT). In this study, we investigated whether recurrence is a risk factor for MT, by longitudinally analyzing cases with recurrent PA (RPA), and carcinomas from PA (CXPA) or RPA (CXRPA). Methods: The study population included 24 CXPA, 24 RPA, 6 CXRPA, and 386 PA cases (study period 2010–2018). Time and event data were collected from the medical documents to identify the time–event sequences. Results: The time interval to MT in CXRPA was significant longer than that of benign recurrence (median 342.0 vs. 109.5 months). In CXRPA, the recurrence intervals were not shorter than those in RPA according to recurrence frequency. Crudely, the MT rate was 5.9% among primary cases and 20.0% among recurrent cases. However, the time-adjusted MT rates increased up to 11.4% (incubation time > 60 months) and 20.0% (>120 months) in primary cases, which were not different from recurrent cases. Conclusion: In these longitudinal analyses, we did not find any clinical evidence that recurrence facilitates MT in the background of PA. Instead, a long incubation time seems to be a key factor for MT of underlying RPA.
A Machine-Learning-Based Risk-Prediction Tool for HIV and Sexually Transmitted Infections Acquisition over the Next 12 Months
Authors: Xu Xianglong , Ge Zongyuan , Chow Eric P. F. , Yu Zhen , Lee David , Wu Jinrong , Ong Jason J. , Fairley Christopher K. , Zhang Lei
Published: March 2022

Background: More than one million people acquire sexually transmitted infections (STIs) every day globally. It is possible that predicting an individual’s future risk of HIV/STIs could contribute to behaviour change or improve testing. We developed a series of machine learning models and a subsequent risk-prediction tool for predicting the risk of HIV/STIs over the next 12 months. Methods: Our data included individuals who were re-tested at the clinic for HIV (65,043 consultations), syphilis (56,889 consultations), gonorrhoea (60,598 consultations), and chlamydia (63,529 consultations) after initial consultations at the largest public sexual health centre in Melbourne from 2 March 2015 to 31 December 2019. We used the receiver operating characteristic (AUC) curve to evaluate the model’s performance. The HIV/STI risk-prediction tool was delivered via a web application. Results: Our risk-prediction tool had an acceptable performance on the testing datasets for predicting HIV (AUC = 0.72), syphilis (AUC = 0.75), gonorrhoea (AUC = 0.73), and chlamydia (AUC = 0.67) acquisition. Conclusions: Using machine learning techniques, our risk-prediction tool has acceptable reliability in predicting HIV/STI acquisition over the next 12 months. This tool may be used on clinic websites or digital health platforms to form part of an intervention tool to increase testing or reduce future HIV/STI risk.
Assessment of Telomere Length and Mitochondrial DNA Copy Number in Granulosa Cells as Predictors of Aneuploidy Rate in Young Patients
Authors: Yu Tzu-Ning , Cheng En-Hui , Tsai Han-Ni , Lin Pin-Yao , Chen Chien-Hong , Huang Chun-Chia , Lee Tsung-Hsien , Lee Maw-Sheng
Published: March 2022

Background: To identify the correlation among female age, cellular aging markers, and aneuploidy rate in in vitro fertilization (IVF) and the preimplantation genetic test for aneuploidy (PGT-A) cycles. Methods: This is a prospective cohort study recruiting 110 infertile women between August 2017 and July 2018. They were divided into young-age (<38 years, n = 60) and advanced-age (≥38 years, n = 50) groups. Peripheral leukocytes were assessed, and the granulosa cells were pooled during oocyte pickup. Mitochondrial DNA (mtDNA) copy number and telomere length (TL) were measured using real-time polymerase chain reaction. PGT-A was performed on the NGS platform. Results: mtDNA copy number and TL were positively correlated in both leukocytes (rho = 0.477, p < 0.001) and granulosa cells (rho = 0.361, p < 0.001), but the two parameters in leukocytes were not correlated with those in granulosa cells. In the young-age group, TL in the granulosa cells was the only factor correlated with the aneuploidy rate (rho = −0.283, p = 0.044), whereas in the advanced-age group, age was the main factor (rho = 0.358, p = 0.018). Conclusions: TL in the granulosa cells was negatively correlated with the aneuploidy rate in the young-age group, supporting the application of PGT-A in younger women.
One Year of Recombinant Human Growth Hormone Treatment in Adults with Prader–Willi Syndrome Improves Body Composition, Motor Skills and Brain Functional Activity in the Cerebellum
Authors: Casamitjana Laia , Blanco-Hinojo Laura , Giménez-Palop Olga , Pujol Jesús , Martínez-Vilavella Gerard , Esteba-Castillo Susanna , Pareja Rocío , Freijo Valentín , Vigil Laura , Deus Joan , Caixàs Assumpta
Published: March 2022

We compared body composition, biochemical parameters, motor function, and brain neural activation in 27 adults with Prader–Willi syndrome and growth-hormone deficiency versus age-and sex-matched controls and baseline versus posttreatment values of these parameters after one year of recombinant human growth hormone (rhGH) treatment. To study body composition, we analyzed percentage of fat mass, percentage of lean mass, and muscle-mass surrogate variables from dual X-ray absorptiometry. Biochemical parameters analyzed included IGF-I, glucose metabolism, and myokines (myostatin, irisin, and IL6). To explore muscle function, we used dynamometer-measured handgrip strength, the Timed Up and Go (TUG) test, and the Berg Balance Scale (BBS). To study brain activation, we acquired functional magnetic resonance images during three motor tasks of varying complexity. After one year of treatment, we observed an increase in lean mass and its surrogates, a decrease in fat mass, improvements in TUG test and BBS scores, and increased neural activation in certain cerebellar areas. The treatment did not significantly worsen glucose metabolism, and no side-effects were reported. Our findings support the benefits of rhGH treatment in adults with Prader–Willi syndrome and growth-hormone deficiency on body composition and suggest that it may also improve balance and brain neural activation.
The Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Association with Physical Function and Prognosis in Patients with Acute Coronary Syndrome
Authors: Noda Takumi , Kamiya Kentaro , Hamazaki Nobuaki , Nozaki Kohei , Ichikawa Takafumi , Yamashita Masashi , Uchida Shota , Maekawa Emi , Terada Tasuku , Reed Jennifer L. , Yamaoka-Tojo Minako , Matsunaga Atsuhiko , Ako Junya
Published: March 2022

It is believed that patients with acute coronary syndrome (ACS) are at an increased risk of nonalcoholic fatty liver disease (NAFLD), which can lead to sarcopenia and physical dysfunction. However, the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and physical dysfunction and prognosis remains unclear. We investigated the prevalence of MAFLD in patients with ACS to assess the relationship between MAFLD and muscle strength, walking speed, and 6-min walking distance (6 MWD). We reviewed patients with ACS who were assessed for hepatic steatosis using the fatty liver index, and the results were further assessed to determine the presence of MAFLD. Among 479 enrolled hospitalized patients, MAFLD was identified in 234 (48.9%) patients. Multiple regression analysis revealed that MAFLD was independently associated with lower leg strength, gait speed, and 6 MWD (leg strength, p = 0.020; gait speed, p = 0.003 and 6 MWD, p = 0.011). Furthermore, in multivariate Poisson regression models after adjustment for clinical confounding factors, combined MAFLD and reduced physical functions were significantly associated with a higher incidence of clinical events. MAFLD is common in hospitalized patients with ACS and is associated with impaired physical function. Also, the coexistence of MAFLD and lower physical function predict the incidence of clinical events in patients with ACS.
Determinants of Quality of Life in Adult Patients with Chronic Non-Bacterial Osteomyelitis (CNO) of the Sternocostoclavicular Region (SCCH): A Dutch Single Center Study
Authors: Ramautar Ashna I. E. , Andela Cornelie D. , Hamdy Neveen A. T. , Winter Elizabeth M. , Appelman-Dijkstra Natasha M.
Published: March 2022

Sternocostoclavicular hyperostosis (SCCH), the main clinical manifestation of chronic non-bacterial osteomyelitis (CNO) in adults, is associated with various degrees of chronic pain and restricted shoulder girdle function. We evaluated the impact of CNO/SCCH on quality of life (QoL) and its determinants in 136 adult patients with this rare auto-inflammatory bone disorder using the Short Form 36, Brief Pain Inventory, Brief Illness Perception, Utrecht Coping List, and Shoulder Rating questionnaires. Data were compared with those of the general Dutch population, patients with chronic pain, fibrous dysplasia, or osteoarthritis. Eighty-six (64%) predominantly female (85%) patients with completed questionnaires were included in the study. Sixty-four (75%) had isolated CNO/SCCH. Mean delay in diagnosis was 3.0 ± 5.5 (SD) years, 90% had variable pain, and 84% limited shoulder function. Compared to healthy and chronically diseased reference populations, CNO/SCCH patients demonstrated significant impairments in almost all aspects of QoL, maladaptive illness perceptions, and ineffective coping strategies. For patients with >5-year delay in diagnosis, higher pain scores and limited shoulder function were identified as determinants for impaired QoL. Patients with CNO/SCCH reported significant impairments in QoL associated with clinical and psychological determinants. Clinical measures such as shortening delay in diagnosis, effective pain management, and psychosocial interventions targeting these factors should help minimize the negative impact of CNO/SCCH on QoL.
Tumor Volume Regression during and after Radiochemotherapy: A Macroscopic Description
Authors: Castorina Paolo , Ferini Gianluca , Martorana Emanuele , Forte Stefano
Published: March 2022

Tumor volume regression during and after chemo and radio therapy is a useful information for clinical decisions. Indeed, a quantitative, patient oriented, description of the response to treatment can guide towards the modification of the scheduled doses or the evaluation of the best time for surgery. We propose a macroscopic algorithm which permits to follow quantitatively the time evolution of the tumor volume during and after radiochemotherapy. The method, initially validated with different cell-lines implanted in mice, is then successfully applied to the available data for partially responding and complete recovery patients.
Evaluating the Effectiveness of Community Public Open Space Renewal: A Case Study of the Ruijin Community, Shanghai
Authors: Cao Yidan , Tang Xiaomin
Published: March 2022

As a vital component of public space, public open space (POS) is considered crucial for community regeneration. However, most evaluation studies have focused on the geographical attributes of POS, and those assessing renewal holistically in terms of residents’ everyday lives are limited. Drawing on the Ruijin community in Shanghai, this study compared networks of public space layout and residents’ daily behaviours as a function of their structure and individual nodes using the Social Network Analysis method to explore the characteristics and evaluate the effectiveness of renewal. The results showed: (1) the current renewal while increasing recreational opportunities and improving spatial appearance has had a limited effect at the social level. (2) There are differentiations between the two networks. POS plays different roles in the behavioural network, including comprehensive, intermediary, and directional nodes. (3) The core POSs have frequent interactions and strong links with specific types of public facilities than the periphery. Therefore, we suggested that POS renewal should be conducted according to the rule of “core preceding periphery, comprehensive high-efficiency preceding single low-efficiency” and explain the necessity of public participation in the process. These findings shed light on the potential mechanism of the impact of POS on everyday life and rethink the construction management and governance of urban community regeneration in the era of sustainability.
Spatio-Temporal Processes and Characteristics of Vegetation Recovery in the Earthquake Area: A Case Study of Wenchuan, China
Authors: Li Jingzhong , Xie Xiao , Zhao Bingyu , Xiao Xiao , Xue Bing
Published: March 2022

The quantitative and qualitative assessment of post-disaster vegetation damage and recovery in the core area of the Wenchuan earthquake is of great significance for the restoration and reconstruction of natural ecosystems and the construction of human settlements in China. This study used time series analysis to determine the time of MODIS data and used the data to study the vegetation damage and restoration in the core area of the Wenchuan earthquake. The determined MODIS images were used to quantitatively analyze a series of vegetation damage changes and the vegetation recovery rate in the core area of the Wenchuan earthquake before and after the earthquake. By applying the topographic factors, we analyzed the spatial and temporal characteristics of the dynamic changes of vegetation damage and the recovery rate in the disaster area. The results show that the study area’s vegetation damage was correlated to topographic factors and distance from towns. Besides, the overall vegetation restoration after the disaster was relatively optimistic. In some areas, the vegetation restoration level even exceeded the vegetation coverage level before the disaster. The recovery study of MODIS-NDVI showed a specific lag delay effect on the image of vegetation cover. The vegetation damage and the recovery rate of vegetation cover were significantly correlated with the distance from towns and the topographic factor. Overall, the results contribute to the theoretical support for the damage and recovery of vegetation in the core area affected by the earthquake.
Managing Land Carrying Capacity: Key to Achieving Sustainable Production Systems for Food Security
Authors: Wang Xiukang
Published: March 2022

Many previous studies have estimated the carrying capacity and feasible planetary boundaries for humankind. However, less attention has been given to how we will sustainably feed 9 billion people in 2050 and beyond. Here, we review the major natural resources that limit food production and discuss possible options, measures, and strategies to sustainably feed a human population of 9 billion in 2050 and beyond. Currently, food production greatly depends on external inputs, e.g., irrigation water and fertilizers, but these approaches are not sustainable. Due to the unbalanced distribution of global natural resources and large regional differences, urbanization expansion causes important areas to face more serious arable land resource shortages. Hence, sustainably feeding 9 billion people in 2050 and beyond remains an immense challenge for humankind, and this challenge requires novel planning and better decision-making tools. Importantly, the measures and strategies employed must be region-/country-specific because of the significant differences in the socioeconomic characteristics and natural environmental carrying capacity in different parts of the world. Considering the impact of unexpected extreme events (e.g., a global pandemic and war) in the future, the food trade and translocation of goods will also face challenges, and the strategies and decision-making processes employed must consider the possible influences at both regional and global scales.
Seasonal Dynamics of Organic Carbon and Nitrogen in Biomasses of Microorganisms in Arable Mollisols Affected by Different Tillage Systems
Authors: Kravchenko Yuriy S. , Zhang Xingyi , Song Chunyu , Hu Wei , Yarosh Anna V. , Voitsekhivska Olena V.
Published: March 2022

Tillage has been reported to induce seasonal changes of organic carbon (Cmicro) and nitrogen (Nmicro) in the biomass of microorganisms. Soil microorganisms execute such ecosystem functions as it is an immediate sink of labile biophil elements; it is an agent of a conversion, catalysis and synthesis of humus substances; it transforms soil contaminants into nonhazardous wastes and it participates in soil aggregation and pedogenesis as a whole. However, the seasonal turnover of microorganisms on arable lands in temperate ecosystems has not been studied at a relevant level. Hence, we are aimed at studying the dynamics of such soil microbial biomass patterns as Cmicro, Nmicro, microbial index (MI = (Cmicro/CTOC)·100%) and CO2-C emissions against the background of 9 years of tillage and 22 years of abandoned (Ab) and fallow (F) usage. Our study was conducted on a long-term experimental site on a Mollisol in Northeast China. The maximum Cmicro and Nmicro contents were recorded at the beginning of the growing season at the 0–10-cm layer and mid-July at the 20–40-cm layer, while the minimum content was during August–October. The Cmicro content ranged from 577.79 to 381.79 mg−1 kg−1 using Ab in the spring to 229.53 to 272.86 mg−1 kg−1 in the autumn using CT (conventional tillage) and F in the 0–10- and 10–20-cm layers, respectively. The amplitude of Nmicro content changes were several times lower as compared with the Cmicro. The smallest quartile range (IQR0.25–0.75) of such changes was shown when using the following treatments: no till (NT) and Ab in the 0–10-, NT and F in the 10–20- and CT in the 20–40-cm layer. The widest Cmicro:Nmicro ratio was recorded at F and CT in the 0–20- and CT and rotational tillage (Rot) in the 20–40-cm layer. The MI dynamics were similar to the trends of Cmicro and Nmicro and changed from 0.72 ± 0.168 to 2.00 ± 0.030%. The highest share of Cmicro in CTOC was at Ab (1.82 ± 1.85%) and NT (1.66 ± 1.52 %) in the 0–10-, Ab (1.23 ± 1.27%) and NT (1.29 ± 1.32%) in the 10–20- and Ab (1.19 ± 1.09%) and F (1.11 ± 1.077%) in the 20–40-cm layer, correspondingly. The Pearson’s correlation coefficient between Cmicro and CTOC increased from the upper 0–10- to the lower 20–40-cm layer; it was “strong” and “high” between Cmicro and CTOC. Different uses of Mollisol affected the amplitude of the Cmicro and Nmicro seasonal changes, but it did not change their trend. Our results suggest the key role of Ab and NT technologies in Cmicro accumulation in the total organic carbon (TOC).
Do Victim Impact Panels Have Sustained Effects on DUI Recidivism?
Authors: Thompson Kevin , Joyce Sarah
Published: March 2022

This study examines whether Victim Impact Panels reduce DUI recidivism 5 to 8 years postsentence. Original 2-year data on 410 DUI offenders who attended a Victim Impact Panel and 373 DUI offenders from the same court system who did not attend a Victim Impact Panel indicated slight recidivism reduction effects. Logistic regression results at the 5-year period reveal that not attending a Victim Impact panel increases the odds of another DUI by a factor of 1.5 with an upper 95% confidence odds level of 2.2. At the 8-year mark, non-VIP participants were 1.8 times more likely to record another DUI with an upper 95% confidence odds level of 2.6. Offenders with a prior DUI who attended a Victim Impact Panel had significantly lower recidivism rates after 8 years relative to non-attendees. Prior research suggested that males in the 26–35-year age group benefitted more from Victim Impact Panel participation. These data indicate that the effects of age are relatively uniform across male age groups. Overall, these recidivism results indicate that the emotional messages communicated by victims to DUI offenders might carry sustained effects.
Diagnostic Value of High-Resolution Ultrasound for the Evaluation of Capsular Width in Temporomandibular Joint Effusion
Authors: Talmaceanu Daniel , Lenghel Lavinia Manuela , Csutak Csaba , Bolog Nicolae , Leucuta Daniel-Corneliu , Rotar Horatiu , Tig Ioan , Buduru Smaranda
Published: March 2022

Aim: The aim of this study was to evaluate if the increased temporomandibular joint (TMJ) capsular thickness, measured by ultrasound (US), is associated with the presence of effusion, diagnosed using MRI imaging. Materials and Methods: 102 patients with signs and symptoms of temporomandibular disorders were included in the study. Each patient underwent US and MRI examinations, 1 to 5 days following clinical examination. The US was performed with an 8–40 MHz linear transducer operating at 20 MHz. The MRI was performed using a 1.5 T MRI device. The ROC curve was analyzed to identify the optimal cut-off value for capsular distention, which can be interpreted as an indirect sign of TMJ effusion. Results: The capsular width values were found to be between 0.7 and 3.6 mm. The best cut-off value was 2.05 mm with a sensitivity of 55.9% and a specificity of 94.7%. The next optimal cut-off value was 1.75 mm with a sensitivity of 67.6% and a specificity of 82.4%. The area under the ROC curve was 0.78 (95% CI 0.68, 0.87, p < 0.05). Conclusions: Ultrasound-measured capsular width can be interpreted as an indirect sign of TMJ effusion. The critical cut-off for capsular width was 2 mm.
Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm
Authors: Rabiu Abubakar Abdullahi , Ahmad Rahnuma , Rowaiye Adekunle Babajide , Rahman Sayeeda , Iskandar Katia , Dutta Siddhartha , Oli Angus Nnamdi , Dhingra Sameer , Tor Maryam Abba , Etando Ayukafangha , Kumar Santosh , Irfan Mohammed , Gowere Marshall , Chowdhury Kona , Akter Farhana , Jahan Dilshad , Schellack Natalie , Haque Mainul
Published: March 2022

COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction of proinflammatory cytokines known as cytokine storm syndrome. This article reported the various checkpoints targeted to manage the SARS-CoV-2-induced cytokine storm. The literature search was carried out using PubMed, Embase, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. Journal articles that discussed SARS-CoV-2 infection and cytokine storm were retrieved and appraised. Specific checkpoints identified in managing SARS-CoV-2 induced cytokine storm include a decrease in the level of Nod-Like Receptor 3 (NLRP3) inflammasome where drugs such as quercetin and anakinra were effective. Janus kinase-2 and signal transducer and activator of transcription-1 (JAK2/STAT1) signaling pathways were blocked by medicines such as tocilizumab, baricitinib, and quercetin. In addition, inhibition of interleukin (IL)-6 with dexamethasone, tocilizumab, and sarilumab effectively treats cytokine storm and significantly reduces mortality caused by COVID-19. Blockade of IL-1 with drugs such as canakinumab and anakinra, and inhibition of Bruton tyrosine kinase (BTK) with zanubrutinib and ibrutinib was also beneficial. These agents' overall mechanisms of action involve a decrease in circulating proinflammatory chemokines and cytokines and or blockade of their receptors. Consequently, the actions of these drugs significantly improve respiration and raise lymphocyte count and PaO2/FiO2 ratio. Targeting cytokine storms' pathogenesis genetic and molecular apparatus will substantially enhance lung function and reduce mortality due to the COVID-19 pandemic.
How to Work with Electromyography Decomposition in Practical Classes of Exercise Physiology and Biomechanics
Authors: Priego-Quesada Jose I. , Goethel Márcio F. , Becker Klaus Magno , Fernandes Ricardo J. , Vilas-Boas João Paulo
Published: March 2022

Concepts about motor unit recruitment are important learning contents in exercise physiology and biomechanics classes that are usually taught theoretically. In the last few years, great advances have occurred in the decomposition of surface electromyography, allowing the learning of theoretical contents in an experimental way. In this tutorial paper, we have described the decomposition of surface electromyography methodological aspects and examples to teach motor unit recruitment concepts in exercise physiology and biomechanics practical lessons. This work has the aim to facilitate physiology and biomechanics academics to introduce this technique in practical classes.
Investigation of Hydrodynamic Performance and Evolution of the near Wake on a Horizontal Axis Tidal Turbine
Authors: Sun Zhaocheng , Feng Long , Mao Yufeng , Li Dong , Zhang Yue , Gao Chengfei , Liu Chao , Fan Menghao
Published: March 2022

The hydrodynamic performance and near wake of tidal current turbines are investigated via numerical simulation and experimental methods in this study. Based on large eddy simulation, the performance and wake characteristics of a tidal 10 kW turbine are then studied at different TSR (Tip Speed Ratio), and the velocity deficit and wake expansion along the flow direction are compared. The equal proportion hydraulic turbine model is designed by the similarity theory, and the experiment was carried out in a water channel, the test parameters including power and torque. The simulation and experimental results show that due to the boundary effect and blocking effect of the flume, there is a certain deviation between the experimental data and the simulation data, but the trend is the same. With the increase of TSR, the pitch of the helix formed by tip vortex gradually decreases, and the tip vortex and root vortex are destroyed earlier in the process of moving downstream. The axial velocity deficit decreases with the increase of axial distance. Finally, the hydrodynamic performance of a turbine is analyzed through experiment and simulation. The experimental results verify and support the simulation results, but there are quantitative differences, and when the TSR = 5, the turbine efficiency has the maximum value.
A Metaheuristic Optimization Approach for Trajectory Tracking of Robot Manipulators
Authors: Lopez-Franco Carlos , Diaz Dario , Hernandez-Barragan Jesus , Arana-Daniel Nancy , Lopez-Franco Michel
Published: March 2022

Due to the complexity of manipulator robots, the trajectory tracking task is very challenging. Most of the current algorithms depend on the robot structure or its number of degrees of freedom (DOF). Furthermore, the most popular methods use a Jacobian matrix that suffers from singularities. In this work, the authors propose a general method to solve the trajectory tracking of robot manipulators using metaheuristic optimization methods. The proposed method can be used to find the best joint configuration to minimize the end-effector position and orientation in 3D, for robots with any number of DOF.
Estimation of Parameters of Different Equivalent Circuit Models of Solar Cells and Various Photovoltaic Modules Using Hybrid Variants of Honey Badger Algorithm and Artificial Gorilla Troops Optimizer
Authors: Rawa Muhyaddin , Abusorrah Abdullah , Al-Turki Yusuf , Calasan Martin , Micev Mihailo , Ali Ziad M. , Mekhilef Saad , Bassi Hussain , Sindi Hatem , Aleem Shady H. E. Abdel
Published: March 2022

Parameters of the solar cell equivalent circuit models have a significant role in assessing the solar cells’ performance and tracking operational variations. In this regard, estimating solar cell parameters is a difficult task because cells have nonlinear current-voltage characteristics. Thus, a fast and accurate optimization algorithm is usually required to solve this engineering problem effectively. This paper proposes two hybrid variants of honey badger algorithm (HBA) and artificial gorilla troops optimizer (GTO) to estimate solar cell parameters. The proposed algorithms minimize the root mean square error (RMSE) between measurement and simulation results. In the first variant, GTO is used to determine the initial population of HBA, while in the second variant, HBA is used to determine the initial population of GTO. These variants can efficiently improve convergence characteristics. The proposed optimization algorithms are applied for parameter estimation of different equivalent circuit models of solar cells and various photovoltaic (PV) modules. Namely, the proposed algorithms test three solar cell equivalent models: single-diode, double-diode, and triple-diode equivalent circuit models. Different photovoltaic modules are investigated, such as the RadioTechnique Compelec (RTC) France solar cell, Solarex’s Multicrystalline 60 watts solar module (MSX 60), and the Photowatt, France solar panel (Photo-watt PWP 201). In addition, the applicability of the proposed optimization algorithms is verified using obtained results from a commercial solar module called Shell Monocrystalline PV module (SM55) with different irradiation and temperature levels. The good results of the proposed algorithms show that they can efficiently improve convergence speed and the accuracy of the obtained results than other algorithms used for parameter estimation of PV equivalent circuit models in the literature, particularly in terms of the values of the RMSE and statistical tests. In addition, the parameters estimated by the proposed methods fit the simulation data perfectly at different irradiance and temperature levels for the commercial PV module.
Family of Distributions Derived from Whittaker Function
Authors: Omair Maha A. , Tashkandy Yusra A. , Askar Sameh , Alzaid Abdulhamid A.
Published: March 2022

In this paper, we introduce a general family of distributions based on Whittaker function. The properties of obtained distributions, moments, ordering, percentiles, and unimodality are studied. The distributions’ parameters are estimated using methods of moments and maximum likelihood. Furthermore, a generalization of Whittaker distribution that contains a wider class of distributions is developed. Validation of the obtained results is applied to real life data containing four data sets.
Genetic Mean Reversion Strategy for Online Portfolio Selection with Transaction Costs
Authors: Moon Seung-Hyun , Yoon Yourim
Published: March 2022

Online portfolio selection (OLPS) is a procedure for allocating portfolio assets using only past information to maximize an expected return. There have been successful mean reversion strategies that have achieved large excess returns on the traditional OLPS benchmark datasets. We propose a genetic mean reversion strategy that evolves a population of portfolio vectors using a hybrid genetic algorithm. Each vector represents the proportion of the portfolio assets, and our strategy chooses the best vector in terms of the expected returns on every trading day. To test our strategy, we used the price information of the S&P 500 constituents from 2000 to 2017 and compared various strategies for online portfolio selection. Our hybrid genetic framework successfully evolved the portfolio vectors; therefore, our strategy outperformed the other strategies when explicit or implicit transaction costs were incurred.
Performance Optimization of a Thermoelectric Device by Using a Shear Thinning Nanofluid and Rotating Cylinder in a Cavity with Ventilation Ports
Authors: Khedher Nidhal Ben , Selimefendigil Fatih , Kolsi Lioua , Aich Walid , Ben Said Lotfi , Boukholda Ismail
Published: March 2022

The combined effects of using a rotating cylinder and shear thinning nanofluid on the performance improvements of a thermoelectric generator (TEG)-installed cavity with multiple ventilation ports are numerically assessed. An optimization algorithm is used to find the best location, rotational speed and size of the cylinder to deliver the highest power generation of the TEG. The power generation features with varying Rew are different for the first nanofluid (NF1) when compared to the second one (NF2). The power rises with higher Rew when NF1 is used, and up to 49% enhancement is obtained. The output power variation between nanofluids NF1 and NF2 is the highest at Rew = 0, which is obtained as 68.5%. When the cylinder location is varied, the change in the output power becomes 61% when NF2 is used. The optimum case has 11.5%- and 161%-higher generated power when compared with the no-object case with NF1 and NF2. The computational effort of using the high-fidelity coupled system is reduced when optimization is considered.
The Ricker Competition Model of Two Species: Dynamic Modes and Phase Multistability
Authors: Kulakov Matvey , Neverova Galina , Frisman Efim
Published: March 2022

The model of two species competing for a resource proposed by R. May and A.P. Shapiro has not yet been fully explored. We study its dynamic modes. The model reveals complex dynamics: multistable in-phase and out-of-phase cycles, and their bifurcations occur. The multistable out-of-phase dynamic modes can bifurcate via the Neimark–Sacker scenario. A value variation of interspecific competition coefficients changes the number of in-phase and out-of-phase modes. We have suggested an approach to identify the bifurcation (period-doubling, pitchfork, or saddle-node bifurcations) due to which in-phase and out-of-phase periodic points appear. With strong interspecific competition, the population’s survival depends on its growth rate. However, with a specific initial condition, a species with a lower birth rate can displace its competitor with a higher one. With weak interspecific competition and sufficiently high population growth rates, the species coexist. At the same time, the observed dynamic mode or the oscillation phase can change due to altering of the initial condition values. The influence of external factors can be considered as an initial condition modification, leading to dynamics shift due to the coexistence of several stable attractors.
Casting and Solidification Processing
Authors: Ferro Paolo
Published: March 2022

Casting is one of the most important shaping processes, largely used and consolidated throughout the world to produce near-net-shaping parts [...]
Productivity Enhancement of Aircraft Turbine Disk Using a Two-Step Strategy Based on Tool-Path Planning and NC-Code Optimization
Authors: Woo Wan-Sik , Curtis David , Bagni Cristian , Lee Choon-Man , Lee Joung-Hwan , Kim Dong-Hyeon
Published: March 2022

Most of the parts of an aircraft require the use of lightweight and high-strength materials. Since aircraft parts mainly use mechanical cutting processes, which are the most suitable material removal mechanism, to minimize changes in material properties, it is necessary to develop an optimal cutting tool and cutting solution for each material. This work aims to enhance productivity and reduce the production cost of an aircraft turbine disk through designing a cutting strategy and optimizing the cutting conditions using a simulation approach. The number of tools was reduced from eight to six compared to the existing process conditions for semi-finishing and finishing of a turbine disk, and a new tool path was proposed through simulation. The cycle time was reduced by about 24%. NC-code optimization was performed through feed-rate optimization considering cutting force and chip thickness. As a result, cycle times were reduced by about 14%. Through tool-path optimization and NC-code optimization, it was confirmed that the total cycle time was reduced by about 54%, and tool wear was significantly improved.
Can Diet Prevent Urological Cancers? An Update on Carotenoids as Chemopreventive Agents
Authors: Konecki Tomasz , Juszczak Aleksandra , Cichocki Marcin
Published: March 2022

Urological cancers, namely prostate, bladder, kidney, testicular, and penile cancers, are common conditions that constitute almost one-quarter of all malignant diseases in men. Urological cancers tend to affect older individuals, and their development is influenced by modifiable metabolic, behavioral, and environmental risk factors. Phytochemicals may have cancer-fighting properties and protect against cancer development, slow its spread, and reduce the risk of cancer deaths in humans. This paper aims to review the current literature in regard to the effects of carotenoids in reducing urological cancer risk.
Effect of Cryopreservation Method Supported with Biochemical Analyses in the Axillary Bud of Jewel Orchid, Ludisia discolor
Authors: Burkhan Hazirah , Rajan Kirutika Selva , Appalasamy Suganthi , Poobathy Ranjetta , Chew Bee Lynn , Mariappan Vanitha , Subramaniam Sreeramanan
Published: March 2022

This study investigated conserving an endangered terrestrial jewel orchid Ludisia discolor, using in vitro grown axillary buds. Excised segments of axillary buds (4–5 mm in length) were precultured on a modified Murashige and Skoog (MS) medium supplemented with 0.2 M sucrose for 24 h and osmoprotected in a loading solution for 20 min. Then, axillary buds were dehydrated in plant vitrification solution 2 (PVS2) for 10 min at 0 °C and incubated in liquid nitrogen for 1 h. Subsequently, axillary buds were rewarmed rapidly by dilution solution and transferred to a growth recovery medium supplemented with 0.05 µM melatonin, which led to an improved survival chance (16.67%) for cryopreserved L. discolor. The osmotic stress and the overproduction of reactive oxygen species (ROS) during cryopreservation stages may result in cryoinjuries and poor survival as increased levels of proline (5.51 µmol/g), catalase (85.64 U/g), peroxidase (565.37 U/g), and ascorbate peroxidase activities (12.19 U/g) were detected after dehydration, preculture, rewarming, and loading stage, respectively. Results obtained from this study indicate that further experimental designs which apply different PVS and exogenous antioxidants are needed for improved survival and regrowth of L. discolor.
Ethnomedicinal Plants in Herbal Remedies Used for Treatment of Skin Diseases by Traditional Healers in Songkhla Province, Thailand
Authors: Saising Jongkon , Maneenoon Katesarin , Sakulkeo Oraphan , Limsuwan Surasak , Götz Friedrich , Voravuthikunchai Supayang Piyawan
Published: March 2022

Skin disorders are a worldwide health problem that normally affect human life. A traditional healer is an important expert in researching notable medicinal plants for skin disease treatment. This study aimed to determine the traditional knowledge and the use of medicinal plants for the treatment of skin diseases among traditional healers in the Songkhla province, Thailand. The ethnobotanical information was collected from experienced traditional healers by semi-structured interviews and participant observations. Plant specimens were also collected and identified using the standard taxonomic method. The data were analyzed by interpretation and descriptive statistics. Twenty-five polyherbal formulations for the treatment of skin diseases were obtained from traditional healers with at least 10 years of experience. A total of 66 plant species in 38 families were documented. Leaves and trees were the most commonly employed plant parts and plant habits included in the herbal remedies, respectively. Fabaceae, Rubiaceae, and Zingiberaceae were the majority of the cited families. Oryza sativa L. and Zingiber montanum (J. Koenig) Link ex A.Dietr. were the most preferred plants combined in the prescriptions, which had the highest use value (UV = 0.83). The highest relative frequency of citation was represented by Curcuma longa L., Eurycoma longifolia Jack, Knema globularia (Lamk.) Warb, and Senna siamea (Lam.) Irwin & Barneby. (0.55 each). This research suggests the importance of traditional healers in the healing of skin diseases with herbal remedies. A variety of medicinal plants are used in the prescriptions for the treatment of skin disorders in the Songkhla province, in the south of Thailand. Pharmacological and toxicological activities as well as phytochemical constituents of polyherbal remedies should be further investigated to scientifically verify further applications of widely practiced herbal medicines.