bluuebunny/crossref_metadata_2025 huggingface dataset:
Fecal Microbiota Perspective for Evaluation of Prebiotic Potential of Bamboo Hemicellulose Hydrolysate in Mice: A Preliminary Study
Authors: Ikeyama Nao , Sakamoto Mitsuo , Ohkuma Moriya , Hiramoto Shigeru , Wang Jianpeng , Tone Shigenobu , Shiiba Kiwamu
Published: April 2021

Bamboo hemicellulose hydrolysate (BHH) may possess antihypercholesterolemic activity; however, this activity requires further comprehensive study to assess the prebiotic mechanisms of BHH in vivo. Here, we used high-throughput 16S rRNA gene sequencing to preliminarily investigate the correlations between BHH and the fecal microbiomes of three groups of mice fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with 5% BHH for 5 weeks. Alpha diversity (within community) was nonsignificant for all groups; however, beta diversity analysis among communities showed that 5% BHH suppressed the significant changes induced by the high-fat diet. The Firmicutes/Bacteroidetes ratio, the family S24-7 within the order Bacteroidales, the family Lachnospiraceae and several cellulolytic taxa were slightly ameliorated in the BHH group. These results indicated that BHH supplementation influenced the gut bacterial community and suppressed the high-fat diet-induced alterations. Additionally, BHH significantly lowered the serum cholesterol levels and fecal pH. Improving short-chain fatty acid production for all of the bacterial communities in the mouse guts may induce this effect. Thus, the prebiotic potential of BHH should be evaluated considering the gut microbial communities and their interactions.
Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Authors: Torres-Ruesta Anthony , Chee Rhonda Sin-Ling , Ng Lisa F.P.
Published: April 2021

Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans. Historically, large outbreaks in susceptible populations have been recorded followed by the development of protective long-lasting antibody responses suggesting a potential advantageous role for a vaccine. Although the current understanding of alphavirus antibody-mediated immunity has been mainly gathered in natural and experimental settings of chikungunya virus (CHIKV) infection, little is known about the humoral responses triggered by other emerging alphaviruses. This knowledge is needed to improve serology-based diagnostic tests and the development of highly effective cross-protective vaccines. Here, we review the role of antibody-mediated immunity upon arthritogenic and neurotropic alphavirus infections, and the current research efforts for the development of vaccines as a tool to control future alphavirus outbreaks.
Copper Slag of Pyroxene Composition as a Partial Replacement of Natural Aggregate for Concrete Production
Authors: Filipović Sandra , Đokić Olivera , Radević Aleksandar , Zakić Dimitrije
Published: April 2021

Copper slag, a by-product of the pyrometallurgical process used for obtaining copper from copper ore in Bor, Serbia, contains mainly silicon, iron, calcium, and aluminium oxides. Due to such properties, it is disposed of in landfills. Despite the favourable technical properties copper slag aggregates possess, such as low-water absorption (WA24 0.6%), low resistance to fragmentation (LA 10%), and low resistance to wear (MDE 4%), its use in the construction industry is still limited. The results of testing the technical properties of copper slag aggregates (CSAs) as a potential replacement for natural river aggregate (RA) are presented in this paper. The experiments included tests on three concrete mixtures with partial replacement of coarse natural aggregate with copper slag. The replacement of RA particle sizes of 8/16 mm and 16/31.5 mm with CSA in the amount of 20% + 50% and 50% + 50% resulted in an increase in the compressive strength of 12.4% and 10.5%, respectively. The increase of CSA content led to a decrease in water penetration resistance and salt-frost resistance of concrete, whereas the resistance to chloride ion penetration did not change significantly.
Electrochemical Performance of Titania 3D Nanonetwork Electrodes Induced by Pulse Ionization at Varied Pulse Repetitions
Authors: Gholami Amirhossein , Yim Chae-Ho , Kiani Amirkianoosh
Published: April 2021

Pulse ionized titania 3D-nanonetworks (T3DN) are emerging materials for fabricating binder-free and carbon-free electrodes for electrochemical energy storage devices. In this article, we investigate the effect of the one of the most important fabrication parameters, pulse frequency, for optimizing supercapacitor efficiency. A series of coin cell batteries with laser-induced electrodes was fabricated; the effect of pulse frequency on oxidation levels and material properties was studied using both experimental and theoretical analysis. Also, detailed electrochemical tests including cyclic voltammetry (CV), charge/discharge, and electrochemical impedance spectroscopy (EIS) were conducted to better understand the effect of pulse frequency on the electrochemical performance of the fabricated devices. The results show that at a frequency of 600 kHz, more T3DN were observed due to the higher temperature and stabler formation of the plasma plume, which resulted in better performance of the fabricated supercapacitors; specific capacitances of samples fabricated at 600 kHz and 1200 kHz were calculated to be 59.85 and 54.39 mF/g at 500 mV/s, respectively.
Applications and Biological Activity of Nanoparticles of Manganese and Manganese Oxides in In Vitro and In Vivo Models
Authors: Sobańska Zuzanna , Roszak Joanna , Kowalczyk Kornelia , Stępnik Maciej
Published: April 2021

The expanding applications of nanotechnology seem to be a response to many technological, environmental, and medical challenges. The unique properties of nanoparticles allow for developing new technologies and therapies. Among many investigated compounds is manganese and its oxides, which in the form of nanoparticles, could be a promising alternative for gadolinium-based contrast agents used in diagnostic imaging. Manganese, which is essential for living organisms as an enzyme cofactor, under excessive exposure—for example, due to water contamination or as an occupational hazard for welders—can lead to neurological disorders, including manganism—a condition similar to Parkinson’s disease. This review attempts to summarise the available literature data on the potential applications of manganese and manganese oxide nanoparticles and their biological activity. Some of the published studies, both in vitro and in vivo, show negative effects of exposure to manganese, mainly on the nervous system, whereas other data suggest that it is possible to develop functionalised nanoparticles with negligible toxicity and novel promising properties.
Green Nanofabrication Opportunities in the Semiconductor Industry: A Life Cycle Perspective
Authors: Mullen Eleanor , Morris Michael A.
Published: April 2021

The turn of the 21st century heralded in the semiconductor age alongside the Anthropocene epoch, characterised by the ever-increasing human impact on the environment. The ecological consequences of semiconductor chip manufacturing are the most predominant within the electronics industry. This is due to current reliance upon large amounts of solvents, acids and gases that have numerous toxicological impacts. Management and assessment of hazardous chemicals is complicated by trade secrets and continual rapid change in the electronic manufacturing process. Of the many subprocesses involved in chip manufacturing, lithographic processes are of particular concern. Current developments in bottom-up lithography, such as directed self-assembly (DSA) of block copolymers (BCPs), are being considered as a next-generation technology for semiconductor chip production. These nanofabrication techniques present a novel opportunity for improving the sustainability of lithography by reducing the number of processing steps, energy and chemical waste products involved. At present, to the extent of our knowledge, there is no published life cycle assessment (LCA) evaluating the environmental impact of new bottom-up lithography versus conventional lithographic techniques. Quantification of this impact is central to verifying whether these new nanofabrication routes can replace conventional deposition techniques in industry as a more environmentally friendly option.
A Unique Case of Bilateral Thalamic High-Grade Glioma in a Pediatric Patient with LI-Fraumeni Syndrome: Case Presentation and Review of the Literature
Authors: Messina Raffaella , Cazzato Gerardo , Perillo Teresa , Stagno Vita , Blè Valeria , Resta Mariachiara , De Leonardis Francesco , Santoro Nicola , Signorelli Francesco , Ingravallo Giuseppe
Published: April 2021

Li-Fraumeni syndrome (LFS) is a rare high-penetrance and autosomal-dominant pathological condition caused by the germline mutation of the TP53 gene, predisposing to the development of tumors from pediatric age. We conducted a qualitative systematic review following the ENTREQ (Enhancing Transparency in Reporting the Synthesis of Qualitative Research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms “Li-Fraumeni” AND “pediatric high-grade glioma (HGG)”, identifying six cases of HGGs in pediatric patients with LFS. We added a further case with peculiar features such as no familiar history of LFS, association of embryonal rhabdomyosarcoma and bithalamic HGG, whose immunohistochemical profile was accurately defined by Next Generation Sequencing. Knowledge synthesis and case analysis grounded the discussion about challenges in the management of this pathology in pediatric age.
The Influence of Nutrition on Adiponectin—A Narrative Review
Authors: Janiszewska Justyna , Ostrowska Joanna , Szostak-Węgierek Dorota
Published: April 2021

The adipose tissue is an active endocrine organ which synthesizes and secretes a variety of adipokines, including adiponectin with its anti-inflammatory properties. Its expression is influenced by numerous factors such as age, sex, body weight and adipose tissue content. However, dietary factors, i.e., diet structure and the percentage of individual nutrients and products, are very important modulators. Beneficial dietary habits are the Mediterranean diet, DASH diet, diet based on plant products and diet with reduced energy value. Moreover, the share of individual products and nutrients which increase the concentration of adiponectin is worth noting. This group may include monounsaturated fatty acids, polyunsaturated omega-3 fatty acids, dietary fiber, polyphenols, alcohol and milk products. Conversely, dietary ingredients which have a negative effect on the concentration of adiponectin are typical components of the Western diet: saturated fatty acids, trans fatty acids, monosaccharides and disaccharides, and red meat. Furthermore, a diet characterized by a high glycemic index such as a high-carbohydrate low-fat diet also seems to be unfavorable. Due to the fact that available knowledge should be systematized, this study aimed to summarize the most recent research on the influence of dietary factors on the concentration of adiponectin.
Mobile Application for Promoting Gluten-Free Diet Self-Management in Adolescents with Celiac Disease: Proof-of-Concept Study
Authors: Meyer Sonya , Naveh Gali
Published: April 2021

Celiac disease (CD) is a chronic disease treated by maintaining and managing a lifelong restrictive gluten-free diet. The purpose of this study was to develop a mobile application, Plan My C-Day, to promote self-management skills among youth with CD during adolescence—a time when decreased adherence often occurs—and examine its usability among adolescents with CD. Plan My C-Day contains three simulations of activities involving eating out and actions to take when preparing for these events. It was developed and pilot tested by 13 adolescents with CD. Application use and user perception data were collected and analyzed. Participants chose 160 actions within the simulations. For over 75% of participants, the time to complete the simulation decreased from the first to the third (last) simulation by an average of 50%. The average reported usability perception was 3.71 on a scale of 1 to 5, with system ease of use and ease of learning obtaining the highest scores. This study demonstrated that the Plan My C-Day mobile application’s self-management content, features, and functions operated well and that the simulations were easy to understand and complete. Further development will include the option to add self-created activities and adaptation to different languages and cultures.
Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet
Authors: Yang Xiao-Yue , Zhong Di-Ying , Wang Guo-Liang , Zhang Run-Guang , Zhang You-Lin
Published: April 2021

As a natural active substance that can effectively improve blood lipid balance in the body, hypolipidemic active peptides have attracted the attention of scholars. In this study, the effect of walnut meal peptides (WMP) on lipid metabolism was investigated in rats fed a high-fat diet (HFD). The experimental results show that feeding walnut meal peptides counteracted the high-fat diet-induced increase in body, liver and epididymal fat weight, and reduce the serum concentrations of total cholesterol, triglycerides, and LDL-cholesterol and hepatic cholesterol and triglyceride content. Walnut meal peptides also resulted in increased HDL-cholesterol while reducing the atherosclerosis index (AI). Additionally, the stained pathological sections of the liver showed that the walnut meal peptides reduced hepatic steatosis and damage caused by HFD. Furthermore, walnut meal peptide supplementation was associated with normalization of elevated apolipoprotein (Apo)-B and reduced Apo-A1 induced by the high-fat diet and with favorable changes in the expression of genes related to lipid metabolism (LCAT, CYP7A1, HMGR, FAS). The results indicate that walnut meal peptides can effectively prevent the harmful effects of a high-fat diet on body weight, lipid metabolism and liver fat content in rats, and provide, and provide a reference for the further development of walnut meal functional foods.
Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels
Authors: Chang Wei-Ting , Wu Sheng-Nan
Published: April 2021

QO-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-7(4H)-one) is a novel and selective activator of KCNQ2/KCNQ3 K+ channels. However, it remains largely unknown whether this compound can modify any other type of plasmalemmal ionic channel. The effects of QO-40 on ion channels in pituitary GH3 lactotrophs were investigated in this study. QO-40 stimulated Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in these cells. QO-40-stimulated IK(Ca) was attenuated by the further addition of GAL-021 or paxilline but not by linopirdine or TRAM-34. In inside-out mode, this compound added to the intracellular leaflet of the detached patches stimulated large-conductance Ca2+-activated K+ (BKCa) channels with no change in single-channel conductance; however, there was a decrease in the slow component of the mean closed time of BKCa channels. The KD value required for the QO-40-mediated decrease in the slow component at the mean closure time was 1.96 μM. This compound shifted the steady-state activation curve of BKCa channels to a less positive voltage and decreased the gating charge of the channel. The application of QO-40 also increased the hysteretic strength of BKCa channels elicited by a long-lasting isosceles-triangular ramp voltage. In HEK293T cells expressing α-hSlo, QO-40 stimulated BKCa channel activity. Overall, these findings demonstrate that QO-40 can interact directly with the BKCa channel to increase the amplitude of IK(Ca) in GH3 cells.
Role of Osteopontin as a Potential Biomarker of Pulmonary Arterial Hypertension in Patients with Systemic Sclerosis and Other Connective Tissue Diseases (CTDs)
Authors: Bellan Mattia , Piccinino Cristina , Tonello Stelvio , Minisini Rosalba , Giubertoni Ailia , Sola Daniele , Pedrazzoli Roberta , Gagliardi Ileana , Zecca Erika , Calzaducca Elisa , Mazzoleni Federica , Piffero Roberto , Patti Giuseppe , Pirisi Mario , Sainaghi Pier Paolo
Published: April 2021

Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue diseases (CTD). Its early diagnosis is essential to start effective treatment. In the present paper, we aimed to evaluate the role of plasma osteopontin (OPN) as a candidate biomarker of PAH in a cohort of CTD patients. OPN is a pleiotropic protein involved in inflammation and fibrogenesis and, therefore, potentially promising in this specific clinical context. We performed a cross-sectional observational study on a cohort of 113 CTD patients (females N = 101, 89.4%) affected by systemic sclerosis N = 88 (77.9%), mixed connective tissue disease N = 10 (8.8%), overlap syndrome N = 10 (8.8%) or undifferentiated connective tissue disease N = 5 (4.4%). CTD-PAH patients showed significantly higher OPN plasma values than patients with CTD alone (241.0 (188.8–387.2) vs. 200.7 (133.5–281.6) ng/mL; p = 0.03). Although OPN levels were directly correlated with age and inversely with glomerular filtration rate, they remained associated with PAH at multivariate analysis. In conclusion, OPN was significantly associated with PAH among patients with CTD, suggesting it may have a role as a non-invasive disease biomarker of PAH.
Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug
Authors: Wang Yuchen , Liu Xiao , Zou Xiaowen , Wang Shuting , Luo Lijun , Liu Yuke , Dong Kai , Yao Xiaoqing , Li Yan , Chen Xiaoguang , Sheng Li
Published: April 2021

IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species. Four metabolites of IMMH-010 were identified, and the major metabolite was the parent compound, YPD-29B, which was mainly catalyzed by carboxylesterase 1 (CES1). We observed IMMH-010 metabolism in the plasma of various species. IMMH-010 was rapidly metabolized to YPD-29B in rat and mouse plasma, whereas it remained stable in human and monkey plasma. In the liver S9 fractions of human, monkey, dog, and rat, IMMH-010 was quickly transformed to YPD-29B with no obvious differences among species. In addition, the transformation ratio of IMMH-010 to YPD-29B was low in rat and human intestines, which indicated that the intestine was not an important site for IMMH-010 hydrolysis. Moreover, we demonstrated the remarkable antitumor efficacy of IMMH-010 in B16F10 melanoma and MC38 colon carcinoma xenograft mouse models. We also compared the pharmacokinetic profiles of IMMH-010 in rodents and primates. After oral administration of IMMH-010, the general exposure of active metabolite YPD-29B was slightly lower in primates than in rodents, suggesting that data should be extrapolated cautiously from rodents to humans.
The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia
Authors: Michelet Robin , Ursino Moreno , Boulet Sandrine , Franck Sebastian , Casilag Fiordiligie , Baldry Mara , Rolff Jens , van Dyk Madelé , Wicha Sebastian G. , Sirard Jean-Claude , Comets Emmanuelle , Zohar Sarah , Kloft Charlotte
Published: April 2021

The treatment of respiratory tract infections is threatened by the emergence of bacterial resistance. Immunomodulatory drugs, which enhance airway innate immune defenses, may improve therapeutic outcome. In this concept paper, we aim to highlight the utility of pharmacometrics and Bayesian inference in the development of immunomodulatory therapeutic agents as an adjunct to antibiotics in the context of pneumonia. For this, two case studies of translational modelling and simulation frameworks are introduced for these types of drugs up to clinical use. First, we evaluate the pharmacokinetic/pharmacodynamic relationship of an experimental combination of amoxicillin and a TLR4 agonist, monophosphoryl lipid A, by developing a pharmacometric model accounting for interaction and potential translation to humans. Capitalizing on this knowledge and associating clinical trial extrapolation and statistical modelling approaches, we then investigate the TLR5 agonist flagellin. The resulting workflow combines expert and prior knowledge on the compound with the in vitro and in vivo data generated during exploratory studies in order to construct high-dimensional models considering the pharmacokinetics and pharmacodynamics of the compound. This workflow can be used to refine preclinical experiments, estimate the best doses for human studies, and create an adaptive knowledge-based design for the next phases of clinical development.
Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release
Authors: Pereira-da-Mota Ana F. , Vivero-Lopez María , Topete Ana , Serro Ana Paula , Concheiro Angel , Alvarez-Lorenzo Carmen
Published: April 2021

Statins are receiving increasing attention in the ophthalmic field. Their activity as 3-hydroxy-3-methylglutaryl–CoA (HMG–CoA) reductase inhibitors is clinically used to regulate cholesterol levels and leads to pleiotropic effects, which may help in the management of diabetes-related ocular pathologies. This work aims to design bioinspired contact lenses (CLs) with an affinity for atorvastatin by mimicking the active site of HMG–CoA reductase. Sets of imprinted and nonimprinted 2-hydroxyethyl methacrylate (HEMA) hydrogels were synthesized, varying the contents in functional monomers that bear chemical groups that resemble those present in HMG–CoA reductase, namely, ethylene glycol phenyl ether methacrylate (EGPEM), 2-aminoethyl methacrylate hydrochloride (AEMA), and N-(3-aminopropyl) methacrylamide hydrochloride (APMA). The hydrogels were characterized in terms of suitability as CLs (solvent uptake, light transmission, mechanical properties, and biocompatibility) and capability to load and release atorvastatin. Three sterilization protocols (steam heat, gamma radiation, and high hydrostatic pressure) were implemented and their effects on hydrogel properties were evaluated. Copolymerization of AEMA and, particularly, APMA endowed the hydrogels with a high affinity for atorvastatin (up to 11 mg/g; KN/W > 200). Only high hydrostatic pressure sterilization preserved atorvastatin stability and hydrogel performance. Permeability studies through the porcine cornea and sclera tissues revealed that the amount of atorvastatin accumulated in the cornea and sclera could be effective to treat ocular surface diseases.
Improving Release of Liposome-Encapsulated Drugs with Focused Ultrasound and Vaporizable Droplet-Liposome Nanoclusters
Authors: Honari Arvin , Merillat Darrah A. , Bellary Aditi , Ghaderi Mohammadaref , Sirsi Shashank R.
Published: April 2021

Active targeted delivery of small molecule drugs is becoming increasingly important in personalized therapies, especially in cancer, brain disorders, and a wide variety of other diseases. However, effective means of spatial targeting and delivering high drug payloads in vivo are still lacking. Focused ultrasound combined with superheated phase-shift nanodroplets, which vaporize into microbubbles using heat and sound, are rapidly becoming a popular strategy for targeted drug delivery. Focused ultrasound can target deep tissue with excellent spatial precision and without using ionizing energy, thus can activate nanodroplets in circulation. One of the main limitations of this technology has been poor drug loading in the droplet core or the shell material. To address this need, we have developed a strategy to combine low-boiling point decafluorabutane and octafluoropropane (DFB and OFP) nanodroplets with drug-loaded liposomes, creating phase-changeable droplet-liposome clusters (PDLCs). We demonstrate a facile method of assembling submicron PDLCs with high drug-loading capacity on the droplet surface. Furthermore, we demonstrate that chemical tethering of liposomes in PDLCs enables a rapid release of their encapsulated cargo upon acoustic activation (>60% using OFP-based PDLCs). Rapid uncaging of small molecule drugs would make them immediately bioavailable in target tissue or promote better penetration in local tissue following intravascular release. PDLCs developed in this study can be used to deliver a wide variety of liposome-encapsulated therapeutics or imaging agents for multi-modal imaging applications. We also outline a strategy to deliver a surrogate encapsulated drug, fluorescein, to tumors in vivo using focused ultrasound energy and PDLCs.
Cleaving of PMMA Microstructured Polymer Optical Fibers with 3- and 4-Ring Hexagonal Cladding Structures
Authors: Guijarro Rubén , Tapetado Alberto , Sánchez Montero David , Vázquez Carmen
Published: April 2021

The cleaving of a novel microstructured polymer optical fiber (mPOF) to obtain an acceptable connectorized fiber end-face is studied. The effect of the blade temperature and the speed of the cutting blade on the end-face is qualitatively assessed. Recently manufactured mPOFs with air-structured 3- and 4-ring hexagonal-like hole cladding structures with outer fiber diameters of around 250 μm are employed. Good quality end-faces can be obtained by cleaving mPOF fibers at room temperature for blade temperatures within the range 60–80 °C and at a low blade speed at 0.5 mm/s. The importance of the blade surface quality is also addressed, being a critical condition for obtaining satisfactory mPOF end-faces after cleaving. From our experiments, up to four fiber cuts with the same razor blade and blade surface can be carried out with acceptable and similar fiber end-face results.
Zero-Discharge Process for Recycling of Tetrahydrofuran–Water Mixtures
Authors: Schuldt Karina , Brinkmann Torsten , Georgopanos Prokopios
Published: April 2021

The sustainable design of separation and polymer synthesis processes is of great importance. Therefore, an energy-efficient process for the purification of tetrahydrofuran (THF)–water (H2O) solvent mixtures from an upstream polymer synthesis process in pilot scale was developed with the aim to obtain high purity separation products. The advantages and limitations of a hybrid process in the pilot scale were studied utilizing an Aspen Plus Dynamics® simulation at different pressures to prove the feasibility and energy efficiency. For the rough separation of the two components, distillation was chosen as the first process step. In this way, a separation of a water stream of sufficient quality for further precipitations after polymer synthesis could be achieved. In order to overcome the limitations of the distillation process posed by the azeotropic point of the mixture, a vapor permeation is used, which takes advantage of the heat of evaporation already used in the distillation column. For the purpose of achieving the required low water contents, an adsorption column is installed downstream for final THF purification. This leads to a novel hybrid separation process that is energy efficient and thus allows also the use of the solvents again for upstream polymer synthesis achieving the high purity requirements in a closed-loop process.
Animating Idolatry: Making Ancestral Kin and Personhood in Ancient Peru
Authors: Lau George F.
Published: April 2021

Historical and archaeological records help shed light on the production, ritual practices, and personhood of cult objects characterizing the central Peruvian highlands after ca. AD 200. Colonial accounts indicate that descendant groups made and venerated stone images of esteemed forebears as part of small-scale local funerary cults. Prayers and supplications help illuminate how different artifact forms were seen as honored family members (forebears, elders, parents, siblings). Archaeology, meanwhile, shows the close associations between carved monoliths, tomb repositories, and restricted cult spaces. The converging lines of evidence are consistent with the hypothesis that production of stone images was the purview of family/lineage groups. As the cynosures of cult activity and devotion, the physical forms of ancestor effigies enabled continued physical engagements, which vitalized both the idol and descendant group.
Effects of Pandemics on Migrant Communities: Analysis of Existing Sources
Authors: Otieno Mollo Kenneth , Nkenyereye Lewis
Published: April 2021

Gender, religion, and migration are perplexing issues, especially in this era of the COVID-19 pandemic in which gendered and religious dynamics are emerging within migrant communities across the world. The relations between these three concepts are explored within this bleak time that has exposed previously neglected dynamics present in migrant communities living in distant host countries in Asia, Europe, and the United States of America. In this paper, we discuss the intricacies within religion and gender among migrant communities and the gendered impacts that COVID-19 has had on the aforementioned migrant communities. Through a secondary desk review analysis of the diverse emerging literature, we show that there are gendered implications of the pandemic measures taken by governments as migrant communities occupy unique translocalities. Overall, the intersection of religion, gender, and migration underscores religion reproducing gender roles among the migrants. The reproduction of gender in religious institutions disadvantage women amidst the COVID-19 pandemic. The analysis confirmed the trivial fact that migrant women continue to suffer disproportionately due to increased unemployment and disease burden coupled with religious practices that continue to advance the upward mobility of male migrants. There is a need to recast the place of migrant women in this era, and lastly, religion plays a renewed role among migrant communities especially for women who have enhanced their social positions and organizational skills through it.
Nationalist Mobilization, Ethno-Religious Contention, and Legal Innovation in a Stateless Nation: Explaining Catalonia’s 2009 “Law on Centers of Worship”
Authors: Astor Avi
Published: April 2021

This article analyzes the development and framing of Catalonia’s “Law on Centers of Worship”, an innovative law dedicated exclusively to the regulation of religious temples that was passed by the regional Parliament in 2009. The law was a legal novelty in Spain, as well as in Europe, where regulations pertaining to places of worship are typically folded into regional or municipal laws and ordinances dealing with zoning and construction. My analysis highlights how the law aimed not only to address the challenges generated by the proliferation of places of worship serving religious minorities, but also to legally reinforce and symbolically affirm Catalonia’s political autonomy and cultural distinctiveness vis-à-vis Spain. I place particular emphasis on how the temporal confluence of heightened nationalist mobilization, on the one hand, and tensions surrounding ethno-religious diversification, on the other, contributed to the development of a legal innovation that integrated the governance of religious diversity within the broader nation-building project. This article’s findings illustrate the role of historical timing and conjunctural causality in shaping the dynamic nexus between religion, law, and politics.
Non-Linear Response of PM2.5 Pollution to Land Use Change in China
Authors: Lu Debin , Mao Wanliu , Xiao Wu , Zhang Liang
Published: April 2021

Land use change has an important influence on the spatial and temporal distribution of PM2.5 concentration. Therefore, based on the particulate matter (PM2.5) data from remote sensing instruments and land use change data in long time series, the Getis-Ord Gi* statistic and SP-SDM are employed to analyze the spatial distribution pattern of PM2.5 and its response to land use change in China. It is found that the average PM2.5 increased from 25.49 μg/m3 to 31.23 μg/m3 during 2000-2016, showing an annual average growth rate of 0.97%. It is still greater than 35 μg/m3 in nearly half of all cities. The spatial distribution pattern of PM2.5 presents the characteristics of concentrated regional convergence. PM2.5 is positively correlated with urban land and farmland, negatively correlated with forest land, grassland, and unused land. Furthermore, the average PM2.5 concentrations show the highest values for urban land and decrease in the order of farmland > unused land > water body > forest > grassland. The impact of land use change on PM2.5 is a non-linear process, and there are obvious differences and spillover effects for different land types. Thus, reasonably controlling the scale of urban land and farmland, optimizing the spatial distribution pattern and development intensity, and expanding forest land and grassland are conducive to curbing PM2.5 pollution. The research conclusions provide a theoretical basis for the management of PM2.5 pollution from the perspective of optimizing land use.
Detecting Recent Crop Phenology Dynamics in Corn and Soybean Cropping Systems of Kentucky
Authors: Yang Yanjun , Tao Bo , Liang Liang , Huang Yawen , Matocha Chris , Lee Chad D. , Sama Michael , Masri Bassil El , Ren Wei
Published: April 2021

Accurate phenological information is essential for monitoring crop development, predicting crop yield, and enhancing resilience to cope with climate change. This study employed a curve-change-based dynamic threshold approach on NDVI (Normalized Differential Vegetation Index) time series to detect the planting and harvesting dates for corn and soybean in Kentucky, a typical climatic transition zone, from 2000 to 2018. We compared satellite-based estimates with ground observations and performed trend analyses of crop phenological stages over the study period to analyze their relationships with climate change and crop yields. Our results showed that corn and soybean planting dates were delayed by 0.01 and 0.07 days/year, respectively. Corn harvesting dates were also delayed at a rate of 0.67 days/year, while advanced soybean harvesting occurred at a rate of 0.05 days/year. The growing season length has increased considerably at a rate of 0.66 days/year for corn and was shortened by 0.12 days/year for soybean. Sensitivity analysis showed that planting dates were more sensitive to the early season temperature, while harvesting dates were significantly correlated with temperature over the entire growing season. In terms of the changing climatic factors, only the increased summer precipitation was statistically related to the delayed corn harvesting dates in Kentucky. Further analysis showed that the increased corn yield was significantly correlated with the delayed harvesting dates (1.37 Bu/acre per day) and extended growing season length (1.67 Bu/acre per day). Our results suggested that seasonal climate change (e.g., summer precipitation) was the main factor influencing crop phenological trends, particularly corn harvesting in Kentucky over the study period. We also highlighted the critical role of changing crop phenology in constraining crop production, which needs further efforts for optimizing crop management practices.
High-Quality Pixel Selection Applied for Natural Scenes in GB-SAR Interferometry
Authors: Deng Yunkai , Tian Weiming , Xiao Ting , Hu Cheng , Yang Hong
Published: April 2021

Phase analysis based on high-quality pixel (HQP) is crucial to ensure the measurement accuracy of ground-based SAR (GB-SAR). The amplitude dispersion (ADI) criterion has been widely applied to identify pixels with high amplitude stability, i.e., permanent scatterers (PSs), which typically are point-wise scatterers such as stones or man-made structures. However, the PS number in natural scenes is few and limits the GB-SAR applications. This paper proposes an improved method to take HQP selection applied for natural scenes in GB-SAR interferometry. In order to increase the spatial density of HQP for phase measurement, three types of HQPs including PS, quasi-permanent scatter (QPS), and distributed scatter (DS), are selected with different criteria. The ADI method is firstly utilized to take PS selection. To select those pixels with high phase stability but moderate amplitude stability, the temporal phase coherence (TPC) is defined. Those pixels with moderate ADI values and high TPC are selected as QPSs. Then the feasibility of the DS technique is explored. To validate the feasibility of the proposed method, 2370 GB-SAR images of a natural slope are processed. Experimental results prove that the HQP number could be significantly increased while slightly sacrificing phase quality.
Monitoring of the Production Process of Graded Concrete Component Using Terrestrial Laser Scanning
Authors: Yang Yihui , Balangé Laura , Gericke Oliver , Schmeer Daniel , Zhang Li , Sobek Werner , Schwieger Volker
Published: April 2021

Accepting the ecological necessity of a drastic reduction of resource consumption and greenhouse gas emissions in the building industry, the Institute for Lightweight Structures and Conceptual Design (ILEK) at the University of Stuttgart is developing graded concrete components with integrated concrete hollow spheres. These components weigh a fraction of usual conventional components while exhibiting the same performance. Throughout the production process of a component, the positions of the hollow spheres and the level of the fresh concrete have to be monitored with high accuracy and in close to real-time, so that the quality and structural performance of the component can be guaranteed. In this contribution, effective solutions of multiple sphere detection and concrete surface modeling based on the technology of terrestrial laser scanning (TLS) during the casting process are proposed and realized by the Institute of Engineering Geodesy (IIGS). A complete monitoring concept is presented to acquire the point cloud data fast and with high-quality. The data processing method for multiple sphere segmentation based on the efficient combination of region growing and random sample consensus (RANSAC) exhibits great performance on computational efficiency and robustness. The feasibility and reliability of the proposed methods are verified and evaluated by an experiment monitoring the production of an exemplary graded concrete component. Some suggestions to improve the monitoring performance and relevant future work are given as well.
Adaptive Waveform Design with Multipath Exploitation Radar in Heterogeneous Environments
Authors: Yilmaz Seden Hazal Gulen , Zarro Chiara , Hayvaci Harun Taha , Ullo Silvia Liberata
Published: April 2021

The problem of detecting point like targets over a glistening surface is investigated in this manuscript, and the design of an optimal waveform through a two-step process for a multipath exploitation radar is proposed. In the first step, a non-adaptive waveform is transmitted and a constrained Generalized Likelihood Ratio Test (GLRT) detector is deduced at reception which exploits multipath returns in the range cell under test by modelling the target echo as a superposition of the direct plus the multipath returns. Under the hypothesis of heterogeneous environments, thus by assuming a compound-Gaussian distribution for the clutter return, this latter is estimated in the range cell under test through the secondary data, which are collected from the out-of-bin cells. The Fixed Point Estimate (FPE) algorithm is applied in the clutter estimation, then used to design the adaptive waveform for transmission in the second step of the algorithm, in order to suppress the clutter coming from the adjacent cells. The proposed GLRT is also used at the end of the second transmission for the final decision. Extensive performance evaluation of the proposed detector and adaptive waveform for various multipath scenarios is presented. The performance analysis prove that the proposed method improves the Signal-to-Clutter Ratio (SCR) of the received signal, and the detection performance with multipath exploitation.
Improving Accuracy of Unmanned Aerial System Thermal Infrared Remote Sensing for Use in Energy Balance Models in Agriculture Applications
Authors: Maguire Mitchell S. , Neale Christopher M. U. , Woldt Wayne E.
Published: April 2021

Unmanned aerial system (UAS) remote sensing has rapidly expanded in recent years, leading to the development of several multispectral and thermal infrared sensors suitable for UAS integration. Remotely sensed thermal infrared imagery has been used to detect crop water stress and manage irrigation by leveraging the increased thermal signatures of water stressed plants. Thermal infrared cameras suitable for UAS remote sensing are often uncooled microbolometers. This type of thermal camera is subject to inaccuracies not typically present in cooled thermal cameras. In addition, atmospheric interference also may present inaccuracies in measuring surface temperature. In this study, a UAS with integrated FLIR Duo Pro R (FDPR) thermal camera was used to collect thermal imagery over a maize and soybean field that contained twelve infrared thermometers (IRT) that measured surface temperature. Surface temperature measurements from the UAS FDPR thermal imagery and field IRTs corrected for emissivity and atmospheric interference were compared to determine accuracy of the FDPR thermal imagery. The comparison of the atmospheric interference corrected UAS FDPR and IRT surface temperature measurements yielded a RMSE of 2.24 degree Celsius and a R2 of 0.85. Additional approaches for correcting UAS FDPR thermal imagery explored linear, second order polynomial and artificial neural network models. These models simplified the process of correcting UAS FDPR thermal imagery. All three models performed well, with the linear model yielding a RMSE of 1.27 degree Celsius and a R2 of 0.93. Laboratory experiments also were completed to test the measurement stability of the FDPR thermal camera over time. These experiments found that the thermal camera required a warm-up period to achieve stability in thermal measurements, with increased warm-up duration likely improving accuracy of thermal measurements.
A Numerical Study on Computational Time Reversal for Structural Health Monitoring
Authors: Panagiotopoulos Christos G. , Stavroulakis Georgios E.
Published: April 2021

Structural health monitoring problems are studied numerically with the time reversal method (TR). The dynamic output of the structure is applied, time reversed, as an external loading and its propagation within the deformable medium is followed backwards in time. Unknown loading sources or damages can be discovered by means of this method, focused by the reversed signal. The method is theoretically justified by the time-reversibility of the wave equation. Damage identification problems relevant to structural health monitoring for truss and frame structures are studied here. Beam structures are used for the demonstration of the concept, by means of numerical experiments. The influence of the signal-to-noise ratio (SNR) on the results was investigated, since this quantity influences the applicability of the method in real-life cases. The method is promising, in view of the increasing availability of distributed intelligent sensors and actuators.
Artificial Intelligence Techniques in Smart Grid: A Survey
Authors: Omitaomu Olufemi A. , Niu Haoran
Published: April 2021

The smart grid is enabling the collection of massive amounts of high-dimensional and multi-type data about the electric power grid operations, by integrating advanced metering infrastructure, control technologies, and communication technologies. However, the traditional modeling, optimization, and control technologies have many limitations in processing the data; thus, the applications of artificial intelligence (AI) techniques in the smart grid are becoming more apparent. This survey presents a structured review of the existing research into some common AI techniques applied to load forecasting, power grid stability assessment, faults detection, and security problems in the smart grid and power systems. It also provides further research challenges for applying AI technologies to realize truly smart grid systems. Finally, this survey presents opportunities of applying AI to smart grid problems. The paper concludes that the applications of AI techniques can enhance and improve the reliability and resilience of smart grid systems.
Aberrant Expression of ZIP and ZnT Zinc Transporters in UROtsa Cells Transformed to Malignant Cells by Cadmium
Authors: Satarug Soisungwan , Garrett Scott H. , Somji Seema , Sens Mary Ann , Sens Donald A.
Published: April 2021

Maintenance of zinc homeostasis is pivotal to the regulation of cell growth, differentiation, apoptosis, and defense mechanisms. In mammalian cells, control of cellular zinc homeostasis is through zinc uptake, zinc secretion, and zinc compartmentalization, mediated by metal transporters of the Zrt-/Irt-like protein (ZIP) family and the Cation Diffusion Facilitators (CDF) or ZnT family. We quantified transcript levels of ZIP and ZnT zinc transporters expressed by non-tumorigenic UROtsa cells and compared with those expressed by UROtsa clones that were experimentally transformed to cancer cells by prolonged exposure to cadmium (Cd). Although expression of the ZIP8 gene in parent UROtsa cells was lower than ZIP14 (0.1 vs. 83 transcripts per 1000 β-actin transcripts), an increased expression of ZIP8 concurrent with a reduction in expression of one or two zinc influx transporters, namely ZIP1, ZIP2, and ZIP3, were seen in six out of seven transformed UROtsa clones. Aberrant expression of the Golgi zinc transporters ZIP7, ZnT5, ZnT6, and ZnT7 were also observed. One transformed clone showed distinctively increased expression of ZIP6, ZIP10, ZIP14, and ZnT1, with a diminished ZIP8 expression. These data suggest intracellular zinc dysregulation and aberrant zinc homeostasis both in the cytosol and in the Golgi in the transformed UROtsa clones. These results provide evidence for zinc dysregulation in transformed UROtsa cells that may contribute in part to their malignancy and/or muscle invasiveness.
Corporate Social Responsibility and Proenvironmental Behaviour in Employees: Evidence in Acapulco, Mexico
Authors: Maldonado Astudillo Rayma Ireri , Maldonado Astudillo Yan Pallac , Méndez Zavala Juan Alfonso , Manzano Jiménez Claudia Leticia , Astudillo Miller María Xochitl
Published: April 2021

Corporate social responsibility (CSR) has been the subject of extensive research, especially during the past two decades; however, few academic studies investigated the relationship between CSR and employee behaviour. This study reduces this gap by identifying the degree of association between CSR and the proenvironmental behaviour (PEB) of workers. These concepts were analysed among companies that are recognised as being socially responsible and others that are not; not enough empirical evidence was found to determine if these are positively affecting employee PEB in the Mexican context. The methodology was quantitative through questionnaires addressed to workers from renowned companies in Mexico, and analysed by using structural equation modelling (SEM) in AMOS software. Results showed that the CSR practices of the companies with a badge and the PEB of their workers are poorly related. The average of compliance with global CSR practices for companies that have a badge is less than or equal to that of those that do not. Conclusions indicate that CSR could occur only in declarative terms from the workers’ perception.