bluuebunny/crossref_metadata_2025 huggingface dataset:
Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States
Authors: Wade Timothy J. , Mistry Jatin H. , Augustine Swinburne A. J. , Griffin Shannon M. , Kobylanski Jason , Styles Jennifer , Sams Elizabeth , Hudgens Edward , Kowalcyk Megan , Cochran Wesley , Ward Honorine , Egorov Andrey
Published: November 2024

Purpose

Tribal Nations disproportionately lack access to safe drinking water and can be adversely affected by other water quality and environmental concerns. Such conditions could lead to an increase in the transmission of waterborne, environmental and hygiene related infections. We collected saliva samples from attendees at two Tribal Nation annual festivals and tested them for salivary immunoglobulin G (IgG) responses to selected common infections using an in-house multiplex immunoassay. Antibody responses were compared to responses from a previously conducted study in the midwestern United States.

Methods

We collected and tested 531 samples from Tribal Nation sites and used data on 453 previously analyzed samples from the Midwest site. Logistic and linear regression models were used to model a binary classification of seropositivity and the intensity of the antibody response, respectively.

Results

Seroprevalence of chronic infections (Helicobacter pylori and Toxoplasma gondii) were generally consistent with estimates from population-based studies. Compared to the Midwest site, one of the Tribal Nation sites had consistently higher median antibody responses to several noroviruses. The Tribal Nation sites had a lower seroprevalence of hepatitis E virus antibodies. At the Tribal Nation sites, farm residents had higher antibody responses to Cryptosporidium spp., bottled water consumption was associated with lower responses to Cryptosporidium spp., animal contact was associated with T. gondii seropositivity, and recent diarrhea was associated with higher norovirus antibody responses. Helicobacter pylori seropositivity was associated with reduced odds of reporting allergies.

Conclusion

This study demonstrated the application of a multiplex salivary immunoassay in Tribal Nations to provide insights regarding selected common pathogens which are transmitted through different transmission pathways including person-to-person contacts, contaminated food, soil and drinking water.
A Survey About Universal Numerical Integrators (UNIs): Part II or Quantitative Approach
Authors: Tasinaffo Paulo M. , Dias Luiz A. V. , da Cunha Adilson M.
Published: November 2024

In Part I, we focused more on the intuitive and geometrical concepts behind Universal Numerical Integrators (UNIs) and their possible classification. This first article worked almost as a categorical analysis for UNIs. In Part I, we also saw an extensive literature review about them. However, in Part II, we examine the mathematics that makes it possible to couple a conventional numerical integrator to some universal approximator of functions. Here, we also present an essential list of the significant mathematical properties related to the design of a UNI. We also hope that the theoretical content in these two articles can help guide researchers aiming to computationally design general problems related to some Universal Numerical Integrator (UNI).
Institutionalizing Investment Dispute Prevention: The U.S. Experience
Authors: Sharpe Jeremy K.
Published: November 2024

The steady rise of international investment arbitration in recent years suggests that many states still struggle to prevent investor grievances from becoming international investment disputes and ultimately arbitration claims. The United States is not exempt from such difficulties, but it has some institutional advantages contributing to its successful approach to mitigating and managing international investment disputes. Key advantages include its practice of: (1) “internationalizing” domestic law in U.S. international investment agreements (IIAs); (2) encouraging foreign investors to pursue domestic remedies in U.S. courts; and (3) domesticating the international investment regime within the U.S. government. The U.S. experience offers some valuable lessons for the ongoing reform of the international investment regime.
Needle-free intradermal vaccination, an opportunity to improve commercial pig welfare
Authors: Lewis Isabel , Wishart Harriet , Breeze Ellie , Setter Poppy , Amory Jonathan
Published: November 2024

In-farm livestock production vaccinations are commonly delivered intramuscularly using needles. While there are alternative strategies these have been subject to little attention and limited commercialisation. One such alternative is needle-free vaccines and studies have focused on the immune response few have addressed the welfare implications. This study aims to compare the impact of intradermal needle-free vaccination and intramuscular injection in terms of the welfare of the piglets. A total of 179 piglets were divided into two treatments: intradermal needle-free delivery and intramuscular delivery of a vaccine. Measures of health and welfare included, vocalisations, behavioural observations, papule formation, and weight. Piglets vaccinated via the needle-free intradermal route vocalised less and displayed no significant behavioural differences but showed increased weight compared to piglets vaccinated intramuscularly. The use of a needle-free device to deliver a vaccine through an intradermal route revealed no adverse effects on piglet welfare and supports the use of alternative strategies to vaccinate livestock.
Career Outcomes Among Neurosurgery Resident Graduates in Canada: An Update
Authors: Elkaim Lior M. , Niazi Farbod , Tso Michael K.
Published: November 2024

Background:

Many Royal College of Physicians and Surgeons of Canada (RCPSC) graduates in neurosurgery face significant challenges in finding full-time employment. The current study describes the career outcomes of neurosurgery residents from Canadian programs.

Methods:

All RCPSC neurosurgery graduates (n = 106) who completed their residency between 2015 and 2020 were included in this study. Baseline characteristics were determined for the entire cohort and then stratified by employment status. Several logistic regression models were used to identify predictors of full-time employment after residency.

Results:

Overall, 26.4% of neurosurgery graduates from 2015 to 2020 have been underemployed, defined as locum and clinical associate positions (6.6%), the pursuit of multiple fellowships (16%) and career change/nonsurgical career (3.8%). Only 52.0% of graduates were fully employed in Canada, with 30.2% appointed at academic institutions. Skull-base/open vascular (OR: 0.055, 95%CI [<0.01, 0.74]) and general neurosurgery (OR: 0.027, 95% CI [<0.01, 0.61]) fellowships were associated with underemployment. Advanced research degrees (master’s or Ph.D.) and sex were not associated with full-time employment.

Conclusions:

Over one-quarter of recent Canadian neurosurgery graduates were underemployed, and nearly half do not find employment in Canada. These results reflect a concerning reality for current and prospective neurosurgery graduates in Canada and will hopefully serve as a call to action for the Canadian neurosurgery community.
The Use of Augmented Reality in Tabletop Exercise for Disaster Preparedness Training: A Descriptive Abstract
Authors: Ahayalimudin Nurul Ain , Ahmad Jais Syaza Izni Inarah
Published: November 2024

Introduction

Augmented reality (AR) is a valuable tool in disaster preparedness training such as tabletop exercises that enhances the exercise by overlaying digital information and virtual objects.

Objective

This study intends to develop an application using AR to be used during the exercise.

Methods

The data is collected through interviews on the opinions and views of the experts from five main agencies in a disaster response; the National Disaster Management Agency, the Royal Malaysia Police, the Fire and Rescue Department of Malaysia, the Ministry of Health, and the Malaysia Civil Defence Department, discussing their duties during a flood scenario. The consensus achieved after series of interviews with the experts, including document reviews guided by National Security Council Directive 20.

Results

The AR approach is created through ‘marker-based’ which use an image recognition to build up an engaging ‘storyline’ of flood scenario. It includes the updates on the changing plot during the exercise using an ‘inject’ meant to progress the plot and provide fresh data to evaluate and react to.

Discussion

Integrating virtual objects and entities into the tabletop exercise is made possible by AR, where it revolutionises how disaster responders being trained using an approach that more engaging and effective.
Tunable X-ray frequency comb generation at the Shanghai soft X-ray Free-Electron Laser facility
Authors: Ni Lanpeng , Xiao Yaozong , Qi Zheng , Feng Chao , Zhao Zhentang
Published: November 2024

X-ray frequency combs (XFCs) are of great interest in many scientific research areas. In this study, we investigate the generation of high-power tunable XFCs at the Shanghai soft X-ray Free-Electron Laser facility (SXFEL). To achieve this, a chirped frequency-beating laser is employed as the seed laser for echo-enabled harmonic generation of free-electron lasers. This approach enables the formation of an initial bunching of combs and ultimately facilitates the generation of XFCs under optimized conditions. We provide an optical design for the chirped frequency-beating seed laser system and outline a method to optimize and set the key parameters that meets the critical requirements for generating continuously tunable XFCs. Three-dimensional simulations using realistic parameters of the SXFEL demonstrate that it is possible to produce XFCs with peak power reaching 1.5 GW, central photon energy at the carbon K edge (~284 eV) and tunable repetition frequencies ranging from 7 to 12 THz. Our proposal opens up new possibilities for resonant inelastic X-ray scattering experiments at X-ray free-electron laser facilities.
Drivers of corporate environmental policy at country, sector, and firm levels
Authors: Jiménez-Parra Beatriz , Fernández-Gago Roberto , Godos-Díez José Luis , Cabeza-García Laura
Published: November 2024

This study provides a holistic approach to the potential drivers of corporate environmental policy. Institutional and/or stakeholder theories are used to explain any influence on this type of policy in situations with different characteristics. Specifically, the analysis considers country-, industry-, and firm-level determinants of an international sample of listed companies. Exploratory factor analysis was first applied to the variables at the country level because their underlying interrelationships were unknown. Using ordered probit models clustered at the firm level, we found that some environmental characteristics of a country and some macro-level variables considered together affect corporate environmental policy, along with pressure from industry peers. Moreover, we observed that companies with better policies for stakeholders, greater board independence, and greater gender diversity tended to develop better environmental policies. This study offers insight into fostering environmental responsibility through policy incentives and effective corporate governance structures.
Busting Myths
Authors: Brown Dorothy A.
Published: November 2024

Andrew Kahrl's timely book, The Black Tax, examines the racial disparities present in local governmental property tax systems. By examining the property tax regime, he enters the conversation about the role of tax policy in exacerbating the racial wealth gap. The Black Tax expands the conversation about analyzing tax policies through a racialized lens.
Hunter S. Thompson: Sportswriter
Authors: Goudsouzian Aram
Published: November 2024

On a winter's night in 1968, in a yellow sedan barreling down a dark New Hampshire highway, Richard M. Nixon talked football with Hunter S. Thompson. Nixon would soon win the state's Republican primary—an important kickoff for his deliberate, disciplined campaign. Thompson was an unlikely choice for an intimate audience with the buttoned-down candidate. The outlaw writer in shabby jeans, a chronicler of hippies and Hell's Angels, cast Nixon as a “foul caricature of himself, a man with no soul, no inner convictions, with the integrity of a hyena and the style of a poison toad.”1
Changing Nationalist Styles in Galicia: The Politics of Dual Identity
Authors: Bello Gabriel G. , Máiz Ramón , Pérez-Boquete Roi
Published: November 2024

In the Spanish region of Galicia, immediately north of Portugal, the Bloque Nacionalista Galego (BNG) has achieved unprecedented electoral success, emerging as a prominent nationalist force within the Spanish political landscape. This study analyzes the discursive and performative repertoires employed by Galician nationalism and explores how the prevalent dual national identity in the region shapes these strategies. Reversing Brubaker’s theoretical framework and using framing and visual analysis, we compare the BNG’s strategies during two different institutional settings: its time in government (2005–2009) and its role leading the opposition (2020–2023). The findings reveal the failure of Galician nationalism to nationalize identity when in power, as policies aimed at promoting Galician identity generated a backlash and, ultimately, produced frame dealignment between the nationalists and the Galician people. The new BNG presents a social project based on the defense of Galician interests and the moderation of the nationalist discourse. It successfully accomplishes frame alignment by adapting to the non-conflictive, dual national identity shared by most Galicians while proposing an inclusive political style.
Designing the Virtual Museum with Animal Crossing: New Horizons
Authors: King Emily Grace
Published: November 2024

In the 2020 video game Animal Crossing: New Horizons, the player builds the collection of the impressive Animal Crossing Museum (ACM). Exploring the visitor experience of this video game museum’s art wing from the perspective of museum professionals allows for the discovery of inventive ways to deepen connection with museum patrons in the virtual space. The ACM is more successful at engaging visitors than traditional virtual museums. It meets visitor needs by offering an immersive, interactive experience, and depends on direct action from the visitor to expand and grow its collection and space. By taking lessons from the player interaction design of the ACM, virtual museums can be designed to meet the psychological needs of visitors and build long-lasting relationships between the visitor and the institution. From the text, this essay proposes seven lessons for designing virtual museums: start with visitor experience at the center of virtual museum design, allow the visitor to collaborate on the creation of the virtual museum, make the virtual museum a habit with intermittent rewards and increased access over time, build social interaction into the virtual museum, add an avatar, show off curator personality, and address colonial roots of museums.
Securing the Future of the Humanities
Authors: Newman Robert D.
Published: November 2024

A decade ago, the American Academy of Arts and Sciences published The Heart of the Matter report to much acclaim. But what has been the impact of such a high-minded report? In the decade since its publication, we have seen a prevailing anti-humanities rhetoric with significant consequences to the security and persistence of humanistic principles. This article focuses on what many consider to be the most crucial problem of our time, climate change and its consequences, in thinking about how this overwhelming problem offers a rallying point for the insertion of the humanities into practical solutions which require an upending of discrete disciplinary perspectives as well as a bridging of the academic and public divide so that any space between the practice of the humanities and advocacy for social and environmental justice is vastly diminished. It argues for a thorough review of academic reward systems, for a broadening of scholarly definitions, and for a pedagogical focus that demands theory commit to empirical application. Finally, it suggests that we reengage our storytelling prowess with an emphasis on the power of metaphor in order to bolster imaginative response and methodological flexibility that is both cogent and compelling.
Associations of saccharin intake with all-cause, cardiovascular and cancer mortality risk in USA adults
Authors: Gao Ya , Yin Li , Zhang Yuntao , Li Xianzhi , Liu Lin
Published: November 2024

Saccharin is a widely used sugar substitute, but little is known about the long-term health effects of saccharin intake. Our study aimed to examine the association between saccharin intake and mortality in diabetic and pre-diabetic population and overweight population from NHANES 1988–1994. Cox proportional hazard models were used to evaluate the association between saccharin intake and CVD, cancer and all-cause mortality. After multivariable adjustment, increased absolute saccharin intake was associated with the risk of all-cause mortality (hazard ratio (HR): 1·41, 95 % CI: 1·05, 1·90), CVD mortality (HR: 1·93, 95 % CI: 1·15, 3·25) and cancer mortality (HR: 2·26, 95 % CI: 1·10, 4·45) in diabetic and pre-diabetic population. Among overweight population, higher absolute saccharin intake was associated with the risk of cancer mortality (HR: 7·369, 95 % CI: 2·122, 25·592). Replacing absolute saccharin intake with total sugar significantly reduced all-cause mortality by 12·5 % and CVD mortality by 49·7 % in an equivalent substitution analysis in the diabetic and pre-diabetic population. Aspartame substitution reduced all-cause mortality by 29·2 % and cancer mortality by 30·2 %. Notably, the relative daily intake of saccharin also had similar effects as the absolute intake on all-cause, cardiovascular and cancer mortality in all analyses. This was despite the fact that the relative daily intake in our study was below the Food and Drug Administration limit of 15 mg/kg. In conclusion, our study showed a considerable risk of increased saccharin intake on the all-cause, CVD mortality and cancer mortality.
Interaction between green tea and metformin and its effects on oxidative stress and inflammation in overweight women: a randomised clinical trial
Authors: de Oliveira Vogado Carolina , Ferreira Monalisa Alves , Nakano Eduardo Yoshio , Azevedo Sabrina , Magalhães Kelly Grace , Fernandes Arruda Sandra , Botelho Patrícia Borges
Published: November 2024

This study evaluated the effect of green tea extract and metformin and its interaction on markers of oxidative stress and inflammation in overweight women with insulin resistance. After screening, 120 women were randomly allocated in 4 groups: Placebo (PC): 1g of microcrystalline cellulose/day; Green tea (GT): 1 g (558 mg polyphenols) of standardized dry extract of green tea/day and 1 g of placebo/day; Metformin (MF): 1 g of metformin/day and 1 g of placebo/day; Green Tea and Metformin (GTMF): 1 g (558 mg polyphenols) and 1 g of metformin/day. All groups were followed-up for 12 weeks with assessment of oxidative damage to lipids and proteins, specific activity of antioxidant enzymes and inflammatory cytokine serum levels. The association of green tea with metformin significantly reduced IL-6 (GTMF: –29.7((–62.6)–20.2))(p = 0.004). Green tea and metformin isolated reduced TNF-α (GT: –12.1((–18.0)–(–3.5)); MF: –24.5((–38.60)–(–4.4)) compared to placebo (PB: 13.8 (1.2–29.2))(P < 0.001). Also, isolated metformin reduced TGF-β (MF: –25.1((–64.4)–0.04)) in comparison to placebo (PB: 6.3((–1.0)–16.3))(p = 0.038). However, when combined, their effects were nullified either for TNF-α (GTMF: 6.0((–5.7)–23.9) and for TGF-β (GTMF: –1.8((–32.1)–8.5). This study showed that there is a drug-nutrient interaction between green tea and metformin that is dependent on the cytokine analyzed.
Of Handbooks, Companions, and Essay Collections: Recent Multi-Authored Volumes on Calvin and Calvinism, the Genevan Reformation, and Global Protestantism
Authors: Benedict Philip
Published: November 2024

Readers of this journal will surely have noticed the remarkable proliferation in the past few decades of “handbooks” and “companions” devoted to major – and even obscure – topics, thinkers, and actors in religious history. The simultaneous appearance in 2021 of The Oxford Handbook of Calvin and Calvinism and Brill's Companion to the Reformation in Geneva provides an opportunity to reflect on the character and value of such volumes, the conditions of their production, and the reasons for their recent proliferation. Also discussed here for purposes of comparison will be an ambitious collection of essays of a more conventional sort: Protestant Empires: Globalizing the Reformations, edited by Ulinka Rublack.1
Health technology assessment for digital health Technologies in India: a framework for action
Authors: John Denny , Dutta Majumdar Abhirup , Pillai Rakesh N. , Khatoon Sajda , Bhattacharya Paramita , Mukherjee Nirmalya , Menon Jaideep C. , Pavithran K. , Kumar Anand , Jakovljevic Mihajlo
Published: November 2024

Objectives

The aim of this study is to understand the path for establishing digital health technologies-health technology assessment (DHT-HTA) in India.

Methods

A rapid review of HTA and DHT frameworks on PubMed (MEDLINE) and Google Scholar was conducted to identify DHT-HTA guidelines, and HTA processes in India. MS-Excel template was created with key domains for assessing DHT in resource-constrained settings based on studies and reports identified. Responses received from seventeen experts with varying expertise in DHT, HTA, clinical, and research were contacted using an online form. Following the principles of qualitative research rooted on grounded theory approach, themes and domains were derived for a framework which was again circulated through participants. Weightage for each theme was assigned based on the frequency of responses and qualifiers were used to interpret results. Inductively derived themes from these responses were clubbed together to identify macro-level systems requirements, and finally pre-requisites for setting up DHT-HTA framework was synthesized.

Results

HT are commonly perceived by experts (64.7 percent participants) as a technology strictly connected to health information. Real-world data (i.e., electronic health data) are recognized as a relevant tool in support of decision-making for clinical and managerial levels. Experts identified some pre-requisites for the establishment of DHT-HTA in the country in terms of infrastructure, contextual factors, training, finance, data security, and scale-up.

Conclusion

Our research not only identified the pre-requisites for the adoption of a DHT-HTA framework for India, but confirmed the need to address DHT-HTA’s acceptability among. Hospitals and health insurance providers.
The European Union and Central Asian Countries’ Activities in the Field of Human Rights: Peculiarities and Directions
Authors: Malgazhdarova Meruyert , Akhmetzhanova Leila , Shaimardanov Zhanibek , Nurdavletova Saniya , Baigondin Rinat
Published: November 2024

This research aims to identify the features and characteristics of the policies of the European Union and Central Asian countries in the sphere of human rights by examining the main vectors and elements of governance at the national and international levels. The research methodology consists of system analysis, which reviews the general situation in the field of civil rights, outlines the problems of protection activities in individual states and regions, and identifies key areas for improvement. The basic elements and components of the activity of the European Union countries in the sphere of protection of fundamental human rights are considered, and the distinctive features of this type of activity in the Central Asian countries are outlined. Positive and negative tendencies of the legal protection of human rights in separate Central Asian states as well as probable scenarios of further development of the sphere in the region are presented. The uniqueness and peculiarities of the Republic of Kazakhstan’s policy in the sphere of human rights protection as a key vector in the process of development of a democratic state are studied. Based on the results, practical recommendations are presented to improve the process of formation of the activity of the Republic in the sphere of human rights and freedoms.
Criteria and diagnostic scale of the post-combat delayed response (tension) syndrome
Authors: Danilevska Natalia
Published: November 2024

Objective

War participation risks mental disorders. Ukrainian combatants in Anti-Terrorist Operation/Joint Forces Operation since 2014 receive psychiatric care. Some show unique symptoms, not fitting recognized disorders, termed post-combat delayed response (tension) syndrome. The aim of this study was to establish diagnostic criteria and develop a scale of differential diagnosis of post-combat delayed response (tension) syndrome.

Methods

This was a clinical retrospective study conducted on the basis of Zaporizhzhia Military Hospital and Zaporizhzhia and State Medical University, Ukraine, in the period from 2015 to 2021. Combatants of Ukraine—members of Anti-Terrorist Operation/Joint Forces Operation were involved in the study. In total, 426 male combatants were surveyed from whom those suffering from post-traumatic stress disorder (n = 24), neurasthenia (n = 35), and post-combat delayed response (tension) syndrome (n = 46) were selected.

Results

The key symptoms of post-combat delayed response (tension) syndrome were selected and ranked in order of their differential diagnostic value. The diagnostic scale for post-combat delayed response (tension) syndrome was developed, which consists of 12 points.

Conclusions

The received anamnestic information is important for classifying patients at risk of post-combat delayed response (tension) syndrome.
Point-to-multipoint beam-steering terahertz communications using a photonics-based leaky-wave transmit antenna
Authors: Tebart Jonas , Dittmer Joel , Haddad Thomas , Matalla Patrick , Lu Peng , Randel Sebastian , Stöhr Andreas
Published: November 2024

We report on the successful implementation of a photonic-based beam steering approach for point-to-multipoint terahertz (THz) communications. The frequency-agile radiation properties of a THz leaky-wave antenna connected to a photodiode are utilized in the remote transmitter for generating multiple individually steerable THz beams. The approach benefits from the ultra-wide frequency tunability of optical heterodyne systems for frequency-agile THz beam steering. Moreover, the approach allows to exploit high performance and mature optical modulation techniques for generating THz beams with a high data capacity. In the THz receiver, a carrier frequency insensitive envelope THz detector based upon a single Schottky-barrier diode is used. In detail, THz communications in the 300 GHz band (WR3.4) with a maximum steering angle up to 90° is reported. Experimentally, for single steerable THz beam operation, a record high data rate of 35 Gbit/s at a wireless distance of 30 cm is achieved using two-level pulse amplitude modulation. Also, longer wireless distances up to 110 cm with 5 Gbit/s are demonstrated. Furthermore, point-to-multipoint THz communications is reported using two individually steerable THz beams carrying 10 Gbit/s and 5 Gbit/s over 70 cm and 50 cm, respectively.
Policy insights on the migration–sustainability nexus for urban governance
Authors: Fry Claudia , Zickgraf Caroline , Boyd Emily , Jolivet Dominique , Siddiqui Tasneem , Fransen Sonja , Gavonel Maria Franco , Adger Neil , Fábos Anita , Connaughton Mark , Abu Mumuni , Codjoe Samuel , de Campos Ricardo Safra
Published: November 2024

Non-technical summary

Cities typically treat migration and sustainability as separate policy domains. When migration is highlighted in the context of sustainability in urban destination areas, it is typically understood to have no, or at worst, negative impacts on sustainability. As a result, migration and migrants are commonly left out of sustainability policy and planning. Here, we present emerging evidence to reframe the debate, demonstrating that migration is a force for sustainable development and that migrants can be sustainability actors in urban environments. We point to key action points for cities to better address the migration–sustainability nexus and harness this potential.

Technical summary

For long, migration has been recognized in literature as a force for societal transformations. Yet, mainstream policies dealing with sustainability generally downplay the role of migration. The Sustainable Development Goals, for example, frame migration as a temporary phenomenon needing management rather than as an integral part of sustainable development. As a result, cities generally overlook broader perspectives on migration and transformation in their sustainability strategies. Here, we present key policy insights building on an emerging field of research exploring the migration–sustainability nexus in urban governance. We focus specifically on the city scale, recognizing that cities are situated at the crossroads of migration and sustainability challenges and opportunities, bringing new possibilities to address current sustainability challenges. For example, migrants interact with their destination areas through influencing consumption behavior and resource conservation and migration contributes to sustainable development through the potential of enhancing wellbeing of residents. There is thus an urgent opportunity to address policy gaps to embrace the potentially transformative role of migration for sustainability transitions. We present critical action points to incorporate new insights into policymaking, emphasizing integrated, coordinated and reflexive approaches across all levels of governance.

Social media summary

Migration drives sustainable development. We show how urban governance can seize opportunities for transformation.
A Novel Sea State Classification Scheme of the Global CFOSAT Wind and Wave Observations
Authors: Li Huimin , Chapron Bertrand , Vandemark Douglas , Lin Wenming , Hauser Danièle , He Yijun , Collard Fabrice
Published: November 2024

Ocean waves are essential elements across the air‐sea interface, regulating momentum and energy transfer. The mixture of wind sea and ocean swell coupled with surface winds results in diverse sea state conditions that modify the local air‐sea interaction. Previous classifications of wind waves and swells are mostly binary that are insufficient to represent the complexity of sea states. In this study, we utilize wind and wave measurements from the China‐France Oceanography Satellite (CFOSAT) to construct an observational wind‐wave ensemble. Four key parameters: wind speed, significant wave height, inverse wave age, and spectral width are selected out of six variables based on their correlations. Employing the unsupervised learning of k‐means clustering, global sea states are categorized into six distinct classes. These classes, characterized by unique centroids and separated in the feature space, represent specific wind regimes and degrees of wave development. Global occurrence highlights that each sea state is region‐specific, bridging the spatial gap of swell and wind sea dominated areas, respectively. This new grouping scheme complements the traditional wind sea and/or swell classification by resolving the diversity of wave regimes. The six‐class classification enables us to identify transitional states and hybrid conditions that may have been overlooked in the binary classification scheme, which shall help investigate the impact of ocean waves on the air‐sea interaction under varying sea states.
Impact of Summer Air Temperature on Water and Solute Transport on a Permafrost‐Affected Slope in West Greenland
Authors: Zastruzny Sebastian F. , Sjöberg Ylva , Jensen Karsten H. , Liu Yijing , Elberling Bo
Published: November 2024

In Arctic landscapes, the active layer forms a near‐surface aquifer on top of the permafrost where water and nutrients are available for plants or subject to downslope transport. Warmer summer air temperatures can increase the thickness of the active layer and alter the partitioning of water into evapotranspiration and discharge by increasing the potential evapotranspiration, the depth to the water table, and changing the flow paths but the interacting processes are poorly understood. In this study, a numerical model for surface‐ and subsurface cryo‐hydrology is calibrated based on field observations from a discontinue permafrost area in West Greenland considered sensitive to future climate changes. The validated model is used to simulate the effect of three summers with contrasting temperature regimes to quantify the variations in the active layer thickness, the resulting changes in the water balance, and the implications on solute transport. We find that an increase of summer air temperature by1.6°C, under similar precipitation can increase the active layer thickness by 0.25 m, increase evapotranspiration by 5%, and reduce the total discharge compared to a colder summer by 9%. Differences in soil moisture and evapotranspiration between upslope and downslope were amplified in a warm summer. These hydrological differences impact solute transport which is 1.6 times faster in a cold summer. Surprisingly, we note that future warmer summer with increase in permafrost thaw may not necessary lead to an increase in discharge along a hill slope with underlying permafrost.
Empirical Model of SSUSI‐Derived Auroral Ionization Rates
Authors: Bender Stefan , Espy Patrick J. , Paxton Larry J.
Published: November 2024

We present an empirical model for auroral (90–150 km) electron–ion pair production rates, ionization rates for short, derived from Special Sensor Ultraviolet Spectrographic Imager electron energy and flux data. Using the Fang et al. (2010, https://doi.org/10.1029/2010gl045406) parametrization for mono‐energetic electrons, and the NRLMSISE‐00 neutral atmosphere model (Picone et al., 2002, https://doi.org/10.1029/2002ja009430), the calculated ionization rate profiles are binned in 2‐hr magnetic local time and 3.6°geomagnetic latitude to yield time series of ionization rates at 5‐km altitude steps. We fit each of these time series to the geomagnetic indices Kp, PC, and Ap, the 81‐day averaged solar radio flux index, and a constant term. The resulting empirical model can easily be incorporated into coupled chemistry–climate models to include particle precipitation effects.
Remotely Sensed Variables Predict Grassland Diversity Better at Scales Below 1,000 km as Opposed to Abiotic Variables That Predict It Better at Larger Scales
Authors: Zhao Yujin , Schmid Bernhard , Zheng Zhaoju , Wang Yang , Wu Jin , Wang Yao , Chen Ziyan , Zhao Xia , Zhao Dan , Zeng Yuan , Bai Yongfei
Published: November 2024

Global spatial patterns of vascular plant diversity have been mapped at coarse grain based on climate‐dominated environment–diversity relationships and, where possible, at finer grain using remote sensing. However, for grasslands with their small plant sizes, the limited availability of vegetation plot data has caused large uncertainties in fine‐grained mapping of species diversity. Here we used vegetation survey data from 1,609 field sites (>4,000 plots of 1 m2), remotely sensed data (ecosystem productivity and phenology, habitat heterogeneity, functional traits and spectral diversity), and abiotic data (water‐ and energy‐related, characterizing climate‐dominated environment) together with machine learning and spatial autoregressive models to predict and map grassland species richness per 100 m2 across the Mongolian Plateau at 500 m resolution. Combining all variables yielded a predictive accuracy of 69% compared with 64% using remotely sensed variables or 65% using abiotic variables alone. Among remotely sensed variables, functional traits showed the highest predictive power (55%) in species richness estimation, followed by productivity and phenology (48%), spectral diversity (48%) and habitat heterogeneity (48%). When considering spatial autocorrelation, remotely sensed variables explained 52% and abiotic variables explained 41%. Moreover, Remotely sensed variables provided better prediction at smaller grain size (<∼1,000 km), while water‐ and energy‐dominated macro‐environment variables were the most important drivers and dominated the effects of remotely sensed variables on diversity patterns at macro‐scale (>∼1,000 km). These findings indicate that while remotely sensed vegetation characteristics and climate‐dominated macro‐environment provide similar predictions for mapping grassland plant species richness, they offer complementary explanations across broad spatial scales.
Afforestation Reduces Deep Soil Carbon Sequestration in Semiarid Regions: Lessons From Variations of Soil Water and Carbon Along Afforestation Stages in China's Loess Plateau
Authors: Huang Yanzhang , Gao Guangyao , Ran Lishan , Wang Yue , Fu Bojie
Published: November 2024

Afforestation represents an effective approach for ecosystem restoration and carbon (C) sequestration. Nonetheless, it poses notable challenges concerning water depletion and soil drought in (semi)arid regions. The underlying mechanisms regulating the influence of afforestation on soil carbon‐water dynamics, particularly how deep soil C reacts to afforestation‐induced soil drying, remain largely unclear. This study examined the variations of soil water content (SWC), soil organic carbon (SOC), and soil inorganic carbon (SIC) in 500 cm depth along four afforestation stages: abandoned grasslands, shrublands, and 20‐year and 40‐year Robinia pseudoacacia forests (RP20 and RP40) in the semiarid Loess Plateau, China. The results indicated that afforestation has significantly increased SWC (+26.6%), SOC (+44.5%), and SIC (+6.5%) in the shallow layer (0–100 cm) but caused evident soil drying (−60.8%), decrease in SOC (−37.8%), and slight reduction in SIC (−0.3%) in the deep layer (300–500 cm) when compared with grasslands. The seriously decline in the coupling coordination between soil C and SWC in the middle and deep layers indicates the unsustainability of afforestation especially for RP40. Structural equation model showed that the negative impact of afforestation on deep SOC through soil water depletion (−0.38) outweighed the direct positive impact of increased aboveground biomass (AGB) (+0.33). The negative impacts of decreased SWC and increased pH on deep SIC was close to the positive impacts of AGB. Afforestation has different effects on SOC and SIC across shallow and deep layers, and its negative effects on deep soil C should be fully integrated into future forest ecosystem restoration and management efforts.
Leveraging convolutional neural networks and hashing techniques for the secure classification of monkeypox disease
Authors: Abdellatef Essam , Ismail Alshimaa H. , Fath Allah M. I. , Shalaby Wafaa A.
Published: November 2024

The World Health Organization declared a state of emergency in 2022 because of monkeypox. This disease has raised international concern as it has spread beyond Africa, where it is endemic. The global community has shown attention and solidarity in combating this disease as its daily increase becomes evident. Various skin symptoms appear in people infected with this disease, which can spread easily, especially in a polluted environment. It is difficult to diagnose monkeypox in its early stages because of its similarity with the symptoms of other diseases such as chicken pox and measles. Recently, computer-aided classification methods such as deep learning and machine learning within artificial intelligence have been employed to detect various diseases, including COVID-19, tumor cells, and Monkeypox, in a short period and with high accuracy. In this study, we propose the CanDark model, an end-to-end deep-learning model that incorporates cancelable biometrics for diagnosing Monkeypox. CanDark stands for cancelable DarkNet-53, which means that DarkNet-53 CNN is utilized for extracting deep features from Monkeypox skin images. Then a cancelable method is applied to these features to protect patient information. Various cancelable techniques have been evaluated, such as bio-hashing, multilayer perceptron (MLP) hashing, index-of-maximum Gaussian random projection-based hashing (IoM-GRP), and index-of-maximum uniformly random permutation-based hashing (IoM-URP). The proposed approach’s performance is evaluated using various assessment issues such as accuracy, specificity, precision, recall, and fscore. Using the IoM-URP, the CanDark model is superior to other state-of-the-art Monkeypox diagnostic techniques. The proposed framework achieved an accuracy of 98.81%, a specificity of 98.73%, a precision of 98.9%, a recall of 97.02%, and fscore of 97.95%.
Population genomics informs the management of harvested snappers across north-western Australia
Authors: Payet Samuel D. , Underwood Jim , Berry Oliver , Saunders Thor , Travers Michael J. , Wakefield Corey B. , Miller Karen , Newman Stephen J.
Published: November 2024

Failure to consider population structure when managing harvested fishes increases the risk of stock depletion, yet empirical estimates of population structure are often lacking for important fishery species. In this study, we characterise genetic variation in single nucleotide polymorphisms (SNPs) to assess population structure for three harvested species of tropical snappers across the broad (up to 300 km wide) and extensive (~ 4000 km) continental shelf of north-western Australia. Comparisons across ~ 300 individuals per species, showed remarkably similar patterns of genetic structure among Lutjanus sebae (red emperor), L. malabaricus (saddletail snapper) and Pristipomoides multidens (goldband snapper) despite subtle differences in biological and ecological traits. Low levels of genetic subdivision were reflected in an isolation by distance relationship where genetic connectivity increased with geographic proximity. This indicates extensive but not unlimited dispersal across the north-western Australian shelf. Our findings provide evidence of connectivity between current management areas, violating the assumption of multiple independent stocks. Spatial stock assessment models may be more suitable for the management of these species however demographic connectivity rates cannot be accurately estimated from the conventional population genetic approaches applied in this study. We recommend that managers aim to maintain adequate spawning biomass across current management areas, and assess stocks at finer scales, where practical.
Early Sri Lankan coastal site tracks technological change and estuarine resource exploitation over the last ca. 25,000 years
Authors: Amano Noel , Faulkner Patrick , Wedage Oshan , Clarkson Chris , Amila Dambara , del Val Miren , Jurkenas Dovydas , Kapukotuwa Alexander , López Gloria I. , Pares Josep , Pathmalal M. M. , Smith Tam , Wright Martin , Roberts Patrick , Petraglia Michael , Boivin Nicole
Published: November 2024

The island of Sri Lanka was part of the South Asian mainland for the majority of the past 115,000 years, and connected most recently during the Last Glacial Maximum via the now submerged Palk Strait. The degree to which rising sea levels shaped past human adaptations from the Pleistocene and into the mid to late Holocene in Sri Lanka has remained unclear, in part because the earliest reliable records of human occupation come from the island’s interior, where cave sites have revealed occupation of tropical forest ecosystems extending back to 48 thousand years (ka). The island’s earliest known open-air sites are all much younger in date, with ages beginning at 15 ka and extending across the Holocene. Here we report the earliest well-dated open-air coastal site in Sri Lanka, Pathirajawela, which records human occupation back to ca. 25,000 years ago. We show that humans at Pathirajawela consistently adapted to changing ecosystems linked to sea level transgression and coastal evolution from the Last Glacial Maximum into the Holocene. The presence of anthropogenic shell midden deposits at the site from ca. 4.8 ka, focused almost exclusively on a single taxon, indicates intensification of estuarine resource exploitation, as humans responded to opportunities presented by the formation of new coastal ecosystems.
ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer
Authors: Voronkova M. A. , Johnson B. , Gandhi N. , Koomen J. M. , Patrick M , Shanthi Bhupathi S. , Wu V. M. , Elliott A. , Vanderwalde A. , Halmos B. , Hazlehurst L. A.
Published: November 2024

We have identified endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) as a poor prognostic indicator in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (EGFRMUT-NSCLC). In addition, comparison of high versus low ERO1A expression among cohorts of EGFRMUT-NSCLC primary samples revealed that ERO1A expression correlated with increased expression of proteins that regulate secretion. Using the CPTAC proteomic data set in lung adenocarcinoma we found that high ERO1A protein expression correlated with both extracellular matrix and matrix modifying enzymes. In this report, we found that ablating ERO1A expression was a determinant of clonogenicity, tumor sphere formation, spheroid growth and growth in vivo, as well as response to Osimertinib. We validated that ERO1A-knockout EGFRMUT-LUAD cell lines demonstrated a reduction in secretion of both laminin gamma 2 (LAMC2) and the collagen modifying enzyme lysyl oxidase-like 2 (LOXL2). Our work supports the role of ERO1A in modulating the tumor microenvironment that is likely to contribute to tumor progression.
The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells
Authors: Shao Anwen , Kissil Joseph L , Fan Chen-Ming
Published: November 2024

Stem cells regenerate differentiated cells to maintain and repair tissues and organs. They also replenish themselves, i.e. self-renew, to support a lifetime of regenerative capacity. Here we study the renewal of skeletal muscle stem cell (MuSC) during regeneration. The transcriptional co-factors TAZ/YAP (via the TEAD transcription factors) regulate cell cycle and growth while the transcription factor YY1 regulates metabolic programs for MuSC activation. We show that MPP7 and AMOT join TAZ and YY1 to regulate a selected number of common genes that harbor TEAD and YY1 binding sites. Among these common genes, Carm1 can direct MuSC renewal. We demonstrate that the L27 domain of MPP7 enhances the interaction as well as the transcriptional activity of TAZ and YY1, while AMOT acts as an intermediate to bridge them together. Furthermore, MPP7, TAZ and YY1 co-occupy the promoters of Carm1 and other common downstream genes. Our results define a renewal program comprised of two progenitor transcriptional programs, in which selected key genes are regulated by protein-protein interactions, dependent on promoter context.
Correlation between vitamin D metabolic pathway-related gene polymorphisms and cardiovascular disease
Authors: Pang Jiao , Yang Chunshuo , Liu Jiaqi , Wang Zhilin , Tao Xueshu , Cao Zhipeng
Published: November 2024

Polymorphisms in key genes in the vitamin D metabolic pathway affect susceptibility to cardiovascular disease (CVD) and play potential roles in the pathogenesis of CVD.
Interaction of oat bran and exercise training improved exercise adaptability via alleviating oxidative stress and promoting energy homeostasis
Authors: Dong Rui , Rafique Hamad , Niu Qianwen , Zeng Xin , Messia Maria Cristina , Yuan Li , Shi Lin , Zou Liang , Li Lu , Hu Xinzhong
Published: November 2024

Interaction of oat bran (OB) diet and moderate intensity exercise training (MlET) reinforced the positive effect on skeletal muscle function.
The near field response of molecules coupled with plasmons at atomistic resolution
Authors: He Huijie , Zhen Xueyang , Li Shuang , Chen Sibing , Chen Xing
Published: November 2024

This study contrasts and quantifies the near-field enhancements under varying resonance conditions and at molecular coverage, validating the self-focusing effect of single molecules at the atomic level.