bluuebunny/crossref_metadata_2025 huggingface dataset:
Children and Adolescents in the United States with Usual High Added Sugars Intake: Characteristics, Eating Occasions, and Top Sources, 2015–2018
Authors: Park Sohyun , Zhao Lixia , Lee Seung Hee , Hamner Heather C. , Moore Latetia V. , Galuska Deborah A. , Blanck Heidi M.
Published: January 2023

Background: High consumption of added sugars is related to adverse health consequences. Objective: The objective of this study was to examine characteristics of US youth who report high intakes of added sugars, as well as the eating occasions and top sources of added sugars that contributed to intakes among consumers with high added sugars intake. Design and participants/setting: We conducted a cross-sectional study using 2015–2018 NHANES data among 5280 US youths (2–19 years). Main outcome measures: Outcome measure was usual percent of calories from added sugars using 2 days of dietary recall based on the National Cancer Institute method. High consumers were defined as consuming greater than 15% of total daily calorie intake from added sugars (1.5 times higher than the 2020–2025 Dietary Guidelines for Americans recommendation of <10% of total daily calorie intake). Explanatory measures were selected sociodemographics (e.g., age, sex, race/ethnicity). Eating occasions were breakfast, lunch, dinner, and snack. Statistical analyses performed: We used t-tests to compare mean differences between sociodemographic groups. Results: Overall, 34% of US youths were classified as high consumers of added sugars. The prevalence of high consumers of added sugars significantly varied by some sociodemographics (i.e., age, race/ethnicity, and head of household’s education level). The prevalence of high added sugars consumers was significantly greater among 12–19-year-olds (41%) and 6–11-year-olds (37%) compared to 2–5-year-olds (19%), non-Hispanic Black (42%) and non-Hispanic White (42%) persons compared to Hispanic persons (19%), and those with a head of household’s education level of high school/some college (40%) compared to households with college degree or higher (29%). The prevalence of high consumers did not differ by sex, income, or weight status. Of eating occasions, the amount of added sugars youths consumed was highest during snack occasions among high consumers. Top five sources of added sugars among high consumers on a given day were sweetened beverages, sweet bakery products, candy, other desserts, and ready-to-eat cereals. Conclusion: One in three US youths consumed more than 15% of total calories from added sugars. High added sugars intake was more prevalent among certain subgroups such as 12–19-year-olds and non-Hispanic Black or non-Hispanic White youth. Our findings can provide information for intervention efforts to decrease added sugars intake to promote child health.
A Rare Ovarian Tumor: The Sclerosing Stromal You Do Not Expect—A Case Series in the Adolescent Population and a Literature Review
Authors: Lucchetti Maria Chiara , Diomedi-Camassei Francesca , Orazi Cinzia , Tassi Alice
Published: January 2023

Sclerosing stromal tumor (SST) is a rare ovarian tumor arising from the sex cord-stromal cells that occurs mainly in young adults during the second and third decades of life and rarely in pediatric and adolescent populations. The objective of this study is to report three illustrative cases of SST in young girls who had undergone surgery at our clinic in or after 2009, and to perform a literature review of this rare ovarian tumor. A retrospective chart review of female patients aged <18 years with a diagnosis of SST treated in a tertiary pediatric hospital was performed. Furthermore, a 10-year review of the SST literature was completed. Three cases of SST at our institution were outlined. After reviewing the literature, 18 SST cases were identified. The mean age at diagnosis was 13.4 years, and the reported clinical presentations were abdominal or pelvic pain and menstrual irregularity. Seven patients had abnormal hormone tests or CA-125 levels. In approximately 30% of cases, conservative surgery was performed, preserving residual ovarian tissue. In conclusion, some preoperative findings may help in suggesting the presence of SST. However, definitive diagnosis can only be made by histopathological examination. It is important to consider this tumor because, given its benign behavior, a conservative approach is preferred, particularly in this age group.
Choroidal Morphology on Ultra-Widefield Indocyanine Green Angiography and Response to Aflibercept in Pachychoroid Neovasculopathy
Authors: Han Su Yeon , Lee Seung Hoon , Lee Phil-kyu , Ra Ho , Baek Jiwon
Published: January 2023

Purpose: This study assessed the relationship between the choroidal morphology and short-term response to aflibercept treatment in pachychoroid neovasculopathy (PNV). Methods: This was a retrospective case-control study. Ultra-widefield indocyanine green angiography (UWICGA) and optical coherence tomography (OCT) images of 90 PNV eyes of 90 patients treated with aflibercept were enrolled. Responsiveness to aflibercept was defined as a complete resolution of sub- or intra-retinal fluid after three loading doses (50 dry and 40 non-dry eyes). Subfoveal choroidal thickness (SFCT) was measured on OCT images, and choroidal vessel density (CVD), CVD asymmetry, intervortex anastomosis, and choroidal vascular hyperpermeability (CVH) were assessed on UWICGA images. Results: CVD on UWICGA differed between groups in terms of the total area (0.323 ± 0.034 in dry vs. 0.286 ± 0.038 in non-dry, p < 0.001) and area of each quadrant (superotemporal: 0.317 ± 0.040 vs. 0.283 ± 0.040, superonasal: 0.334 ± 0.040 vs. 0.293 ± 0.045, inferonasal: 0.306 ± 0.051 vs. 0.278 ± 0.052, inferotemporal: 0.334 ± 0.047 vs. 0.290 ± 0.046; all p ≤ 0.010). The CVH grade differed between groups (mean 1.480 ± 0.735 vs. 1.875 ± 0.822, p = 0.013). ST and IT intervortex anastomoses were common in the dry group, while SN, ST, and IT were most common in the non-dry group (p = 0.001). Conclusions: A poor short-term response to aflibercept treatment in PNV eyes was associated with a lower Haller vessel density, higher CVH grade, and intervortex anastomosis involving more quadrants on UWICGA.
Long-Term Lithium Therapy: Side Effects and Interactions
Authors: Ferensztajn-Rochowiak Ewa , Rybakowski Janusz K.
Published: January 2023

Lithium remains the drug of first choice for prophylactic treatment of bipolar disorder, preventing the recurrences of manic and depressive episodes. The longitudinal experiences with lithium administration greatly exceed those with other mood stabilizers. Among the adverse side effects of lithium, renal, gastrointestinal, neurological, thyroid, metabolic, cognitive, dermatological, cardiologic, and sexual are listed. Probably, the most important negative effect of lithium, occurring mostly after 10–20 years of its administration, is interstitial nephropathy. Beneficial side-effects of long-term lithium therapy also occur such as anti-suicidal, antiviral, and anti-dementia ones. Pharmacokinetic and pharmacodynamic interactions of lithium, mostly those with other drugs, may have an impact on the success of long-term lithium treatment. This paper makes the narrative updated review of lithium-induced side-effects and interactions that may influence its prophylactic effect in bipolar disorder. Their description, mechanisms, and management strategies are provided. The papers appearing in recent years focused mainly on the long-term lithium treatment are reviewed in detail, including recent research performed at Department of Psychiatry, Poznan University of Medical Sciences, Poland. Their own observations on ultra-long lithium treatment of patients with bipolar disorder are also presented. The review can help psychiatrists to perform a successful lithium prophylaxis in bipolar patients.
Development and Validation of a Non-Targeted Screening Method for Most Psychoactive, Analgesic, Anaesthetic, Anti-Diabetic, Anti-Coagulant and Anti-Hypertensive Drugs in Human Whole Blood and Plasma Using High-Resolution Mass Spectrometry
Authors: Feliu Catherine , Konecki Celine , Cazaubon Yoann , Binet Laurent , Vautier Damien , Fouley Aurélie , Gozalo Claire , Djerada Zoubir
Published: January 2023

(1) Background: In toxicological laboratories, various screening methods can be used to identify compounds involved in intoxication. High-resolution mass spectrometry has been increasingly used in this context for the last years, because of its sensitivity and reliability. Here, we present the development and validation of a screening method that uses liquid chromatography coupled with a high-resolution mass spectrometer. (2) Methods: This method required only 100 µL of whole blood or plasma sample. Pretreatment consisted of a rapid and simple deproteinisation with methanol/acetonitrile and zinc sulphate. This new assay was validated according to international guidelines. (3) Results: To perform the method validation, 53 compounds were selected. The selection criteria were as follows: various chemical structures and therapeutic families (>15), large m/z distribution, positive or negative ionisation mode, and various elution times. The assays showed high selectivity and specificity, with optimal process efficiency. The identification limits, determined using predefined criteria, were established at sub-therapeutic or therapeutic concentrations. Applicability was evaluated using spiked plasma controls and external quality controls. (4) Conclusions: The new method was then successfully applied to routine clinical and forensic samples.
Effect of Polar Head Group Modifications on the Tumor Retention of Phospholipid Ether Analogs: Role of the Quaternary Nitrogen
Authors: Pinchuk Anatoly N. , Rampy Mark A. , Longino Marc A. , Durkee Ben Y. , Counsell Raymond E. , Weichert Jamey P.
Published: January 2023

We have previously described the remarkable capacity of radioiodinated alkyl phospholipids to be sequestered and retained by a variety of tumors in vivo. We have already established the influence of certain structural parameters of iodinated alkyl phospholipids on tumor avidity, such as stereochemistry at the sn-2 carbon of alkylglycerol phosphocholines, meta-or para-position of iodine in the aromatic ring of phenylalkyl phosphocholines, and the length of the alkyl chain in alkyl phospholipids. In order to determine the additional structural requirements for tumor uptake and retention, three new radioiodinated alkylphospholipid analogs, 2–4, were synthesized as potential tumor imaging agents. Polar head groups were modified to determine structure-tumor avidity relationships. The trimethylammonio group in 1 was substituted with a hydrogen atom in 2, an ammonio group in 3 and a tertiary butyl group in 4. All analogs were separately labeled with iodine-125 or iodine-124 and administered to Walker 256 tumor-bearing rats or human PC-3 tumor-bearing SCID mice, respectively. Tumor uptake was assessed by gamma-camera scintigraphy (for [I-125]-labeled compounds) and high-resolution micro-PET scanning (for [I-124]-labeled compounds). It was found that structural modifications in the polar head group of alkyl phospholipids strongly influenced the tumor uptake and tissue distribution of these compounds in tumor-bearing animals. Phosphoethanolamine analog 3 (NM401) displayed a very slight accumulation in tumor as compared with phosphocholine analog 1 (NM346). Analogs 2 (NM400) and 4 (NM402) lacking the positively charged nitrogen atom failed to display any tumor uptake and localized primarily in the liver. This study provided important insights regarding structural requirements for tumor uptake and retention. Replacement of the quaternary nitrogen in the alkyl phospholipid head group with non-polar substituents resulted in loss of tumor avidity.
Retrospectives on Three Decades of Safe Clinical Experience with Allogeneic Dermal Progenitor Fibroblasts: High Versatility in Topical Cytotherapeutic Care
Authors: Laurent Alexis , Rey Marina , Scaletta Corinne , Abdel-Sayed Philippe , Michetti Murielle , Flahaut Marjorie , Raffoul Wassim , de Buys Roessingh Anthony , Hirt-Burri Nathalie , Applegate Lee Ann
Published: January 2023

Allogeneic dermal progenitor fibroblasts constitute cytotherapeutic contenders for modern cutaneous regenerative medicine. Based on advancements in the relevant scientific, technical, and regulatory fields, translational developments have slowly yet steadily led to the clinical application of such biologicals and derivatives. To set the appropriate general context, the first aim of this study was to provide a current global overview of approved cell and gene therapy products, with an emphasis on cytotherapies for cutaneous application. Notable advances were shown for North America, Europe, Iran, Japan, and Korea. Then, the second and main aim of this study was to perform a retrospective analysis on the various applications of dermal progenitor fibroblasts and derivatives, as clinically used under the Swiss progenitor cell transplantation program for the past three decades. Therein, the focus was set on the extent and versatility of use of the therapies under consideration, their safety parameters, as well as formulation options for topical application. Quantitative and illustrative data were summarized and reported for over 300 patients treated with various cell-based or cell-derived preparations (e.g., progenitor biological bandages or semi-solid emulsions) in Lausanne since 1992. Overall, this study shows the strong current interest in biological-based approaches to cutaneous regenerative medicine from a global developmental perspective, as well as the consolidated local clinical experience gathered with a specific and safe allogeneic cytotherapeutic approach. Taken together, these current and historical elements may serve as tangible working bases for the further optimization of local and modern translational pathways for the provision of topical cytotherapeutic care.
Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation
Authors: Lage Nayara Almeida , de Paiva Mayara Rodrigues Brandão , Vasconcelos-Santos Daniel Vitor , Machado Renes Resende , Fialho Sílvia Ligório , Silva-Cunha Armando
Published: January 2023

Mometasone furoate (MF) is a medium-potency synthetic glucocorticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. However, its role in the treatment of ocular inflammation has not yet been explored. This work investigated the anti-inflammatory activity of MF in ocular tissues. First, the in vivo safety of the intravitreal (IVT) injection of MF (80, 160, and 240 µg) was evaluated via clinical examination (including the assessment of intraocular pressure), electroretinography (ERG), and histopathology. Second, MF was tested in an experimental model of bacillus Calmette–Guérin (BCG)-induced uveitis in Wistar rats. Intraocular inflammation was then evaluated via a slit-lamp and fundus examination, ERG, histopathology, and the quantification of pro-inflammatory markers. Intravitreal MF showed no toxicity in all the investigated doses, with 160 µg leading to attenuated disease progression and improvement in clinical, morphological, and functional parameters. There was a significant reduction in the levels of inflammatory markers (myeloperoxidase, interleukins 6 and 1β, CXCL-1, and tumor necrosis factor-alpha) when compared to the levels in untreated animals. Therefore, MF should be further investigated as a promising drug for the treatment of ocular inflammation.
Somaclonal Variation for Genetic Improvement of Starch Accumulation in Potato (Solanum tuberosum) Tubers
Authors: Adly Walaa M. R. M. , Niedbała Gniewko , EL-Denary Mohammad E. , Mohamed Mahasen A. , Piekutowska Magdalena , Wojciechowski Tomasz , Abd El-Salam El-Sayed T. , Fouad Ahmed S.
Published: January 2023

Starch content is one of the major quality criteria targeted by potato breeding programs. Traditional potato breeding is a laborious duty due to the tetraploid nature and immense heterozygosity of potato genomes. In addition, screening for functional genetic variations in wild relatives is slow and strenuous. Moreover, genetic diversity, which is the raw material for breeding programs, is limited due to vegetative propagation used in the potato industry. Somaclonal variation provides a time-efficient tool to breeders for obtaining genetic variability, which is essential for breeding programs, at a reasonable cost and independent of sophisticated technology. The present investigation aimed to create potato somaclones with an improved potential for starch accumulation. Based on the weight and starch content of tubers, the somaclonal variant Ros 119, among 105 callus-sourced clones, recorded a higher tuberization potential than the parent cv Lady Rosetta in a field experiment. Although this somaclone was similar to the parent in the number of tubers produced, it exhibited tubers with 42 and 61% higher fresh and dry weights, respectively. Additionally, this clone recorded 10 and 75% increases in starch content based on the dry weight and average content per plant, respectively. The enhanced starch accumulation was associated with the upregulation of six starch-synthesis-related genes, namely, the AGPase, GBSS I, SBE I, SBE II, SS II and SS III genes. AGPase affords the glycosyl moieties required for the synthesis of amylose and amylopectin. GBSS is required for amylose elongation, while SBE I, SBE II, SS II and SS III are responsible for amylopectin.
The Roads to Haploid Embryogenesis
Authors: Shen Kun , Qu Mengxue , Zhao Peng
Published: January 2023

Although zygotic embryogenesis is usually studied in the field of seed biology, great attention has been paid to the methods used to generate haploid embryos due to their applications in crop breeding. These mainly include two methods for haploid embryogenesis: in vitro microspore embryogenesis and in vivo haploid embryogenesis. Although microspore culture systems and maize haploid induction systems were discovered in the 1960s, little is known about the molecular mechanisms underlying haploid formation. In recent years, major breakthroughs have been made in in vivo haploid induction systems, and several key factors, such as the matrilineal (MTL), baby boom (BBM), domain of unknown function 679 membrane protein (DMP), and egg cell-specific (ECS) that trigger in vivo haploid embryo production in both the crops and Arabidopsis models have been identified. The discovery of these haploid inducers indicates that haploid embryogenesis is highly related to gamete development, fertilization, and genome stability in ealry embryos. Here, based on recent efforts to identify key players in haploid embryogenesis and to understand its molecular mechanisms, we summarize the different paths to haploid embryogenesis, and we discuss the mechanisms of haploid generation and its potential applications in crop breeding. Although these haploid-inducing factors could assist egg cells in bypassing fertilization to initiate embryogenesis or trigger genome elimination in zygotes after fertilization to form haploid embryos, the fertilization of central cells to form endosperms is a prerequisite step for haploid formation. Deciphering the molecular and cellular mechanisms for haploid embryogenesis, increasing the haploid induction efficiency, and establishing haploid induction systems in other crops are critical for promoting the application of haploid technology in crop breeding, and these should be addressed in further studies.
Interpenetration Networked Polyimide–Epoxy Copolymer under Kinetic and Thermodynamic Control for Anticorrosion Coating
Authors: Chen Dong-Sen , Chen Chun-Hua , Whang Wha-Tzong , Su Chun-Wei
Published: January 2023

Epoxy (EP) was copolymerized with polyamic acid (PAA, precursor of polyimide (PI)) with termanil monomers of (1) 4,4′-Oxydianiline (ODA) and (2) pyromellitic dianhydride (PMDA) individually to form (PI-O-EP) and (PI-P-EP) copolymers. The FTIR spectrum of PI-O-EP copolymerization intermediates shows that some amide-EP linkages were formed at low temperature and were broken at higher temperature; in additoin, the released amide was available for subsequent imidization to form PI. The curing and imidization of the amide groups on PAA were determined by reaction temperature (kinetic vs. thermodynamic control). In PI-P-EP, the released amide group was very short-lived (fast imidization) and was not observed on FTIR spectra. Formation and breakage of the amide-EP linkages is the key step for EP homopolymerization and formation of the interpenetration network. PI contributed in improving thermal durability and mechanical strength without compromising EP’s adhesion strength. Microphase separations were minimal at PI content less than 10 wt%. The copolymerization reaction in this study followed the “kinetic vs. thermodynamic control” principle. The copolymer has high potential for application in the field of higher-temperature anticorrosion.
Quantitative Measurements of DP in Cellulose Paper Based on Terahertz Spectroscopy
Authors: Chen Qiyu , Yang Lijun , Yu Hua , He Yuxin , Liu Hong , Wang Xuan
Published: January 2023

The power transformer is vital to the reliability of the power grid which is most commonly insulated with Kraft paper and immersed in mineral oil, among which the aged state of the paper is mainly correlated to the operating life of the transformer. Degree of polymerization (DP) is a direct parameter to assess the aged condition of insulating paper, but existing DP measurement by viscosity methods are destructive and complicated. In this paper, terahertz time-domain spectroscopy (THz-TDS) was introduced to reach rapid, non-destructive detection of the DP of insulating paper. The absorption spectra of insulating paper show that characteristic peak regions at 1.8 and 2.23 THz both exhibit a log-linear quantitative relationship with DP, and their universalities are confirmed by conducting the above relationship on different types of insulating paper. Fourier transform infrared spectroscopy (FTIR) analysis and molecular dynamics modeling further revealed that 1.8 and 2.23 THz were favorably associated with the growth of water–cellulose hydrogen bond strength and amorphous cellulose, respectively. This paper demonstrates the viability of applying THz-TDS to the non-destructive detection of DP in insulating paper and assigned the vibration modes of the characteristic absorption peaks.
N-Containing Hybrid Composites Coatings for Enhanced Fire-Retardant Properties of Cotton Fabric Using One-Pot Sol–Gel Process
Authors: Khan Laila , Kim Jong Seop , Huh Seok-Hwan , Koo Bon Heun
Published: January 2023

In this report, a unique methodology/process steps were followed using Sol–gel-based concept to deposit thin flame-retardant coatings on cotton fabric. Surface microstructure and compositional analysis of the coated cotton were carried out using scanning electronic microscope (SEM), which explored significant coverage of the fabric. The obtained samples were further analyzed through rupturing mechanism test and color check. Compositional investigation of the coated samples was carried through Attenuated total reflection Fourier transform infrared (ATR–FTIR) and energy-dispersive X-rays spectroscopy (EDS) analysis. Thermal analyses were carried out through Thermogravimetric analysis (TGA) and Vertical flame tests (VFT), which suggested higher resistance of the coatings obtained for 5 h and zero heat-treatment time on the cotton fabric. A 28.86% char residue was obtained for the same sample (ET–5h–RT) coupled with higher degradation temperature and excellent combustion properties.
Special Aspects of Nitrocellulose Molar Mass Determination by Dynamic Light Scattering
Authors: Solovov Roman , Kazberova Anfisa , Ershov Boris
Published: January 2023

The dynamic light scattering method was successfully applied to determine the molar mass of nitrocellulose. The methodology of nitrocellulose fractionation in acetonic solutions is described in detail; six polymer fractions with monomodal distribution were obtained. It was shown that the unfractionated colloxylin with polymodal molar mass distribution had mass average molecular mass values of 87.3 ± 14.1, 28.3 ± 7.3, and 0.54 ± 0.17 kDa when investigated by the dynamic light scattering method. The viscometric method only provided integral viscosity average molar mass equal to 56.7 ± 5.8 kDa.
Synthesis and Characterization of 𝒌-Carrageenan/PVA Nanocomposite Hydrogels in Combination with MgZnO Nanoparticles to Evaluate the Catechin Release
Authors: Sabbagh Farzaneh , Khatir Nadia Mahmoudi , Kiarostami Khadijeh
Published: January 2023

In the current study, nanocomposites were prepared by combining k-carrageenan, polyvinyl alcohol (PVA), and doped nanoparticles (Magnesium oxide) MgO, (Magnesium Zinc oxide) MgZnO 1%, MgZnO 3%, and MgZnO 5%. The nanoparticles were synthesized by a sol–gel method and mixed with a mixture of k-carrageenan/PVA (Ca/PVA) in various ratios. The structure of the composites was analyzed using thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The Ca/PVA mixture was then mixed with nanoparticles and loaded with active ingredient, catechin. Scanning electron microscope (SEM) and texture analysis were performed to analyze the nanocomposites. Entrapment efficiency (EE%) and drug release studies confirmed that k-carrageenan/PVA/MgZnO 5% had the highest EE% at 81.58% and a drug release of 75.21% ± 0.94. The EE% of k-carrageenan/PVA/MgO was 55.21% and its drug release was 45%. This indicates that ZnO plays an effective role in the structure and performance of Ca/PVA composites. The SEM images of MgO composites show smoother surfaces compared to MgZnO composites. This may be one of the reasons for the increased EE% and drug release of MgZnO composites. The addition of ZnO to the composite structure can lead to the appearance of pores on the surface of the composite, increasing entrapment and drug release.
Fiber Reinforced Polymer Debonding Failure Identification Using Smart Materials in Strengthened T-Shaped Reinforced Concrete Beams
Authors: Zapris Adamantis G. , Naoum Maria C. , Kytinou Violetta K. , Sapidis George M. , Chalioris Constantin E.
Published: January 2023

The favorable contribution of externally bonded fiber-reinforced polymer (EB-FRP) sheets to the shear strengthening of reinforced concrete (RC) beams is widely acknowledged. Nonetheless, the premature debonding of EB-FRP materials remains a limitation for widespread on-site application. Once debonding appears, it is highly likely that brittle failure will occur in the strengthened RC structural member; therefore, it is essential to be alerted of the debonding incident immediately and to intervene. This may not be always possible, particularly if the EB-FRP strengthened RC member is located in an inaccessible area for fast inspection, such as bridge piers. The ability to identify debonding immediately via remote control would contribute to the safer application of the technique by eliminating the negative outcomes of debonding. The current investigation involves the detection of EB-FRP sheet debonding using a remotely controlled electromechanical admittance (EMA)-based structural health monitoring (SHM) system that utilizes piezoelectric lead zirconate titanate (PZT) sensors. An experimental investigation on RC T-beams strengthened for shear with EB-FRP sheets has been performed. The PZT sensors are installed at various locations on the surface of the EB-FRP sheets to evaluate the SHM system’s ability to detect debonding. Additionally, strain gauges were attached on the surface of the EB-FRP sheets near the PZT sensors to monitor the deformation of the FRP and draw useful conclusions through comparison of the results to the wave-based data provided by the PZT sensors. The experimental results indicate that although EB-FRP sheets increase the shear resistance of the RC T-beams, premature failure occurs due to sheet debonding. The applied SHM system can sufficiently identify the debonding in real-time and appears to be feasible for on-site applications.
Marginal and Internal Fit of Monolithic Zirconia Crowns Fabricated by Using Two Different CAD-CAM Workflows: An In Vitro Study
Authors: Çin Vahap , İzgi Ayça Deniz , Kale Ediz , Yilmaz Burak
Published: January 2023

Objectives: Few studies have evaluated the marginal fit of computer-aided design—computer-aided manufacturing (CAD-CAM) monolithic zirconia crowns fabricated through completely digital workflow; however, the internal fit of these restorations is not well known. The purpose of this in vitro study was to evaluate the marginal and internal fit of monolithic zirconia crowns fabricated by using digital workflow, including intraoral scanner (IOS) scans, and compare the results to those of a semi-digital workflow, which combined conventional impressions, poured casts, and extraoral scanner (EOS) scanning. Materials and methods: A typodont right mandibular first molar was prepared for a complete-coverage ceramic crown and scanned using an IOS. The conventional impressions of the preparation were also made, and stone casts were poured and scanned by using an EOS. Virtual models were generated for both workflows, and identical virtual anatomic contour crowns were designed using CAD software. Monolithic zirconia crowns were fabricated for both IOS (ZI; n = 10) and EOS (ZE; n = 10) groups. The silicon replica technique was used to evaluate the marginal and internal fit of the crowns. Measurements were made at 13 points on buccolingual and mesiodistal cross-sections per specimen with a ×6.5 to ×50 zoom stereo microscope. The results from both groups were statistically compared using the Independent Samples t-tests and the Mann–Whitney U test (α = 0.05). Results: Mean gap values at all measurement locations for ZE were significantly higher than those for ZI (p ≤ 0.002). Overall mean values ranged between 29 and 43 µm (median: 28–42 µm) for ZI and 42 and 75 µm (median: 43–77 µm) for ZE. Conclusion: Completely digital workflow through intraoral scans provided significantly better marginal and internal fit for CAD-CAM monolithic zirconia crowns compared with the semi-digital workflow, where stone casts obtained from conventional impressions were scanned with an EOS. Yet, both workflows provided an acceptable marginal and internal fit for CAD-CAM monolithic zirconia molar crowns (<120 µm). Clinical Relevance: Completely digital workflow using IOS scans may be advantageous for the fabrication of CAD-CAM monolithic zirconia crowns as favorable results can be obtained with less material waste and potentially shortened overall treatment time as the impression files can be transferred to the production facility electronically. The results need to be corroborated with clinical studies.
Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease
Authors: Patil Nikhil Y. , Friedman Jacob E. , Joshi Aditya D.
Published: January 2023

Numerous nuclear receptors including farnesoid X receptor, liver X receptor, peroxisome proliferator-activated receptors, pregnane X receptor, hepatic nuclear factors have been extensively studied within the context of non-alcoholic fatty liver disease (NAFLD). Following the first description of the Aryl hydrocarbon Receptor (AhR) in the 1970s and decades of research which unveiled its role in toxicity and pathophysiological processes, the functional significance of AhR in NAFLD has not been completely decoded. Recently, multiple research groups have utilized a plethora of in vitro and in vivo models that mimic NAFLD pathology to investigate the functional significance of AhR in fatty liver disease. This review provides a comprehensive account of studies describing both the beneficial and possible detrimental role of AhR in NAFLD. A plausible reconciliation for the paradox indicating AhR as a ‘double-edged sword’ in NAFLD is discussed. Finally, understanding AhR ligands and their signaling in NAFLD will facilitate us to probe AhR as a potential drug target to design innovative therapeutics against NAFLD in the near future.
Souls and Selves: Querying an AI Self with a View to Human Selves and Consciousness
Authors: Oberg Andrew
Published: January 2023

The question of self-aware artificial intelligence may turn on the question of the human self. To explore some of the possibilities in play we start from an assumption that the self is often pre-analytically and by default conceptually viewed along lines that have likely been based on or from the kind of Abrahamic faith notion as expressed by a “true essence” (although not necessarily a static one), such as is given in the often vaguely used “soul”. Yet, we contend that the self is separately definable, and in relatively narrow terms; if so, of what could the self be composed? We begin with a brief review of the descriptions of the soul as expressed by some sample scriptural references taken from these religious lineages, and then transition to attempt a self-concept in psychological and cognitive terms that necessarily differentiates and delimits it from the ambiguous word “soul”. From these efforts too will emerge the type of elements that are needed for a self to be present, allowing us to think of the self in an artificial intelligence (AI) context. If AI might have a self, could it be substantively close to a human’s? Would an “en-selved” AI be achievable? I will argue that there are reasons to think so, but that everything hinges on how we understand consciousness, and hence ruminating on that area—and the possibility or lack thereof in extension to non-organic devices—will comprise our summative consideration of the pertinent theoretical aspects. Finally, the practical will need to be briefly addressed, and for this, some of the questions that would have to be asked regarding what it might mean ethically to relate to AI if an “artificial self” could indeed arise will be raised but not answered. To think fairly about artificial intelligence without anthropomorphizing it we need to better understand our own selves and our own minds. This paper will attempt to analyze the self within these bounds.
The Saint Dionysius and Saint Margaret Altarpiece from the Cathedral of València
Authors: Ramón i Ferrer Lluis
Published: January 2023

This work studies the iconography of Vicent Macip’s altarpiece dedicated to Saint Dionysius and Saint Margaret, which is found in the Cathedral of València. The main subject of the altarpiece is the presence of the Virgin Mary in salvation history. Iconographic categories have been described according to their possible relationship to the descriptions that appear in Francesc Eiximenis’s Vida de Jesucrist [Life of Jesus Christ, in Catalan] (Hereafter, this text will be referred to as VCE). or Isabel de Villena’s Vita Christi [Life of Christ, in Latin] (Hereafter, this text will be referred to as VCV), which are important works of 15th-century Valencian literature in the Catalan language that were read during the time the altarpiece was finished.
Design, Manufacturing, and Trial of a 3D Printed Customized Finger Splint for Patients with Rheumatoid Arthritis
Authors: Chhikara Komal , Gupta Shubham , Saharawat Sakshi , Sarkar Shruti , Chanda Arnab
Published: January 2023

Rheumatoid arthritis has become one of the most common inflammatory diseases and plays a major role in the disability of the population affected by it. The prevalence of finger deformities in the upper extremity caused by rheumatoid arthritis is increasing day by day, especially in low and middle-income countries such as India. For the management of these finger deformities, the splinting options are either customized or prefabricated. The performance and success of finger splinting depend on several factors, including precision, aesthetics, patient acceptance, comfort, the convenience of usage, effects, price, and side effects. However, to date, customized splints are high-cost and usually fabricated by conventional production techniques, which dominantly work on approximation. This study focused on the development of a novel finger splint through computational optimization and 3D printing for the management of boutonniere and swan neck deformity caused by rheumatoid arthritis. Twenty subjects with finger deformities were recruited, and the performance of the 3D-printed splint was characterized. The results were assessed using the nine-hole peg test and QUEST 2.0, which showed positive effects of the splint, including achievement of corrected joint positions, finger dexterity, and comfort. Such a low-cost and effective splint, with further acceptability testing, is anticipated to be a better line of conservative management for patients affected by rheumatoid arthritis.
Fusion and Classification of SAR and Optical Data Using Multi-Image Color Components with Differential Gradients
Authors: Shakya Achala , Biswas Mantosh , Pal Mahesh
Published: January 2023

This paper proposes a gradient-based data fusion and classification approach for Synthetic Aperture Radar (SAR) and optical image. This method is used to intuitively reflect the boundaries and edges of land cover classes present in the dataset. For the fusion of SAR and optical images, Sentinel 1A and Sentinel 2B data covering Central State Farm in Hissar (India) was used. The major agricultural crops grown in this area include paddy, maize, cotton, and pulses during kharif (summer) and wheat, sugarcane, mustard, gram, and peas during rabi (winter) seasons. The gradient method using a Sobel operator and color components for three directions (i.e., x, y, and z) are used for image fusion. To judge the quality of fused image, several fusion metrics are calculated. After obtaining the resultant fused image, gradient based classification methods, including Stochastic Gradient Descent Classifier, Stochastic Gradient Boosting Classifier, and Extreme Gradient Boosting Classifier, are used for the final classification. The classification accuracy is represented using overall classification accuracy and kappa value. A comparison of classification results indicates a better performance by the Extreme Gradient Boosting Classifier.
Towards Unified Online-Coupled Aerosol Parameterization for the Brazilian Global Atmospheric Model (BAM): Aerosol–Cloud Microphysical–Radiation Interactions
Authors: Pendharkar Jayant , Figueroa Silvio Nilo , Vara-Vela Angel , Krishna R. Phani Murali , Schuch Daniel , Kubota Paulo Yoshio , Alvim Débora Souza , Vendrasco Eder Paulo , Gomes Helber Barros , Nobre Paulo , Herdies Dirceu Luís
Published: January 2023

In this work, we report the ongoing implementation of online-coupled aerosol–cloud microphysical–radiation interactions in the Brazilian global atmospheric model (BAM) and evaluate the initial results, using remote-sensing data for JFM 2014 and JAS 2019. Rather than developing a new aerosol model, which incurs significant overheads in terms of fundamental research and workforce, a simplified aerosol module from a preexisting global aerosol–chemistry–climate model is adopted. The aerosol module is based on a modal representation and comprises a suite of aerosol microphysical processes. Mass and number mixing ratios, along with dry and wet radii, are predicted for black carbon, particulate organic matter, secondary organic aerosols, sulfate, dust, and sea salt aerosols. The module is extended further to include physically based parameterization for aerosol activation, vertical mixing, ice nucleation, and radiative optical properties computations. The simulated spatial patterns of surface mass and number concentrations are similar to those of other studies. The global means of simulated shortwave and longwave cloud radiative forcing are comparable with observations with normalized mean biases ≤11% and ≤30%, respectively. Large positive bias in BAM control simulation is enhanced with the inclusion of aerosols, resulting in strong overprediction of cloud optical properties. Simulated aerosol optical depths over biomass burning regions are moderately comparable. A case study simulating an intense biomass burning episode in the Amazon is able to reproduce the transport of smoke plumes towards the southeast, thus showing a potential for improved forecasts subject to using near-real-time remote-sensing fire products and a fire emission model. Here, we rely completely on remote-sensing data for the present evaluation and restrain from comparing our results with previous results until a complete representation of the aerosol lifecycle is implemented. A further step is to incorporate dry deposition, in-cloud and below-cloud scavenging, sedimentation, the sulfur cycle, and the treatment of fires.
A Step-Wise Workflow for SAR Remote Sensing of Perennial Heaving Mound/Crater on the Yamal Peninsula, Western Siberia
Authors: Bondur Valery , Chimitdorzhiev Tumen , Dmitriev Aleksey
Published: January 2023

Climate change in the Arctic region is more significant than in other parts of our planet. One of the manifestations of these changes is crater creation with blowouts of a gas, ice and frozen soil mixture. In this context, dynamics studies of long-term heaving mounds that turn into craters as a result are relevant. A workflow for detecting and assessing anomalous dynamics of heaving mounds in the Arctic regions is proposed. Areas with anomalous increase of ALOS-2 PALSAR-2 synthetic aperture radar (SAR) backscattering intensity are detected in the first stage. These increases take place due to sudden changes in local terrain slopes when the scattering surface (mound slope) turns toward the radar. Radar backscattering intensity also rises due to depolarization at newly formed frost cracks. Validation of the detected anomaly is carried out at the second stage through a comparison of multi-temporal digital elevation models obtained from bistatic radar interferometry TerraSAR-X/TanDEM-X data. At the final stage, the deformations are assessed within the detected areas using differential SAR interferometry (DInSAR) technique by ALOS-2 PALSAR-2 data. The magnitude of the heaving along the line of sight (LOS) was 22–24 cm in the period from January 2019 to January 2020. In general, effectiveness for detecting the perennial heaving mounds and the rate assessment of their increase were demonstrated in the suggested workflow.
New Approach for Photogrammetric Rock Slope Premonitory Movements Monitoring
Authors: Núñez-Andrés Mª Amparo , Prades-Valls Albert , Matas Gerard , Buill Felipe , Lantada Nieves
Published: January 2023

An automated, fixed-location, continuous time-lapse camera system was developed to analyze the existence of rockfall precursory movements and quantify volume changes after detachments. It was implemented to monitor the basaltic formation on which Castellfollit de la Roca village is built. Due to the geometrical conditions of the area, the camera system consists of three digital cameras managed by a control unit that contains a Raspberry Pi 4 microprocessor. Images taken every day are sent to a server for processing. A workflow has been developed to work with a set of images with an irregular time interval to detect precursor movement. The first step consists of matching the images with a reference master image and filtering the vegetation to improve the process using a mask obtained by a green leaf index (GLI) index. Then, the adjusted images are used for a forward-backward correlation process carried out to detect movements. If movement is detected, a 3D model is built using structure from motion (SfM) to quantify the movements. The system has been working since September 2021. During this period, movements from 0.01 to 0.5 m and several rockfalls of a small volume have been detected.
Shoreline Change Assessment in the Coastal Region of Bangladesh Delta Using Tasseled Cap Transformation from Satellite Remote Sensing Dataset
Authors: Shamsuzzoha Md , Ahamed Tofael
Published: January 2023

Bangladesh is a global south hotspot due to climate change and sea level rise concerns. It is a highly disaster-prone country in the world with active deltaic shorelines. The shorelines are quickly changing to coastal accretion and erosion. Erosion is one of the water hazards to landmass sinking, and accretion relates to land level rises due to sediment load deposition on the Bay of Bengal continental shelf. Therefore, this study aimed to explore shoreline status with change assessment for the three study years 1991, 2006, and 2021 using satellite remote sensing and geographical information system (GIS) approaches. Landsat 5, 7 ETM+, and 8 OLI satellite imageries were employed for onshore tasseled cap transformation (TCT) and land and sea classification calculations to create shore boundaries, baseline assessment, land accretion, erosion, point distance, and near feature analysis. We converted 16,550 baseline vertices to points as the study ground reference points (GRPs) and validated those points using the country datasheet collected from the Survey of Bangladesh (SoB). We observed that the delta’s shorelines were changed, and the overall lands were accredited for the land-increasing characteristics analysis. The total accredited lands in the coastal areas observed during the time periods from 1991 to 2006 were 825.15 km2, from 2006 to 2021 was 756.69 km2, and from 1991 to 2021 was 1223.94 km2 for the 30-year period. Similarly, coastal erosion assessment analysis indicated that the results gained for the period 1991 to 2006 and 2006 to 2021 were 475.87 km2 and 682.75 km2, respectively. Therefore, the total coastal erosion was 800.72 km2 from 1991 to 2021. Neat accretion was 73.94 km2 for the 30-year period from 1991 to 2021. This research indicates the changes in shorelines, referring to the evidence for the delta’s active formation through accretion and erosion processes of ‘climate change’ and ‘sea level rise’. This research projects the erosion process and threatens land use changes toward agriculture and settlements in the coastal regions of Bangladesh.
LiDAR-Based Local Path Planning Method for Reactive Navigation in Underground Mines
Authors: Jiang Yuanjian , Peng Pingan , Wang Liguan , Wang Jiaheng , Wu Jiaxi , Liu Yongchun
Published: January 2023

Reactive navigation is the most researched navigation technique for underground vehicles. Local path planning is one of the main research difficulties in reactive navigation. At present, no technique can perfectly solve the problem of local path planning for the reactive navigation of underground vehicles. Aiming to address this problem, this paper proposes a new method for local path planning based on 2D LiDAR. First, we convert the LiDAR data into a binary image, and we then extract the skeleton of the binary image through a thinning algorithm. Finally, we extract the centerline of the current laneway from these skeletons and smooth the obtained roadway centerline as the current planned local path. Experiments show that the proposed method has high robustness and good performance. Additionally, the method can also be used for the global path planning of underground maps.
Effect of the Synergetic Use of Sentinel-1, Sentinel-2, LiDAR and Derived Data in Land Cover Classification of a Semiarid Mediterranean Area Using Machine Learning Algorithms
Authors: Valdivieso-Ros Carmen , Alonso-Sarria Francisco , Gomariz-Castillo Francisco
Published: January 2023

Land cover classification in semiarid areas is a difficult task that has been tackled using different strategies, such as the use of normalized indices, texture metrics, and the combination of images from different dates or different sensors. In this paper we present the results of an experiment using three sensors (Sentinel-1 SAR, Sentinel-2 MSI and LiDAR), four dates and different normalized indices and texture metrics to classify a semiarid area. Three machine learning algorithms were used: Random Forest, Support Vector Machines and Multilayer Perceptron; Maximum Likelihood was used as a baseline classifier. The synergetic use of all these sources resulted in a significant increase in accuracy, Random Forest being the model reaching the highest accuracy. However, the large amount of features (126) advises the use of feature selection to reduce this figure. After using Variance Inflation Factor and Random Forest feature importance, the amount of features was reduced to 62. The final overall accuracy obtained was 0.91 ± 0.005 (α = 0.05) and kappa index 0.898 ± 0.006 (α = 0.05). Most of the observed confusions are easily explicable and do not represent a significant difference in agronomic terms.