bluuebunny/crossref_metadata_2025 huggingface dataset:
Solving Nonlinear Fractional Partial Differential Equations Using the Elzaki Transform Method and the Homotopy Perturbation Method
Authors: Mohamed Mohamed. Z. , Yousif Mohammed , Hamza Amjad E.
Published: August 2022

In this paper, we combine the Elzaki transform method (ETM) with the new homotopy perturbation method (NHPM) for the first time. This hybrid approach can solve initial value problems numerically and analytically, such as nonlinear fractional differential equations of various normal orders. The Elzaki transform method (ETM) is used to solve nonlinear fractional differential equations, and then the homotopy is applied to the transformed equation, which includes the beginning conditions. To obtain the solution to an equation, we use the inverse transforms of the Elzaki transform method (ETM). The initial conditions have a big impact on the equation’s result. We give three beginning value issues that were solved as precise or approximation solutions with high rigor to demonstrate the method’s power and correctness. It is clear that solving nonlinear partial differential equations with the crossbred approach is the best alternative.
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis
Authors: Huang Yue-bo , Jiang Ling , Liu Xue-qi , Wang Xian , Gao Li , Zeng Han-xu , Zhu Wei , Hu Xue-ru , Wu Yong-gui
Published: August 2022

Acute kidney injury (AKI) is still a puzzling clinical problem; its pathophysiology is not completely understood. Up to now, an effective treatment for AKI is lacking. Ferroptosis is a novel form of regulated cell death characterized by the lethal accumulation of lipid hydroperoxides that are dependent on iron and reactive oxygen species and mitochondrial dysfunction. Recently, ferroptosis was shown to play a vital role in AKI such as ischemia-reperfusion kidney injury and folic acid-induced AKI. Melatonin (MT) is an antioxidant that regulates the sleep-wake cycle. While the therapeutic effect of melatonin on AKI has been reported, its mechanism for the treatment of renal ferroptosis remains unclear. We found that melatonin treatment significantly alleviated the serum biochemistry index and histopathological alterations in vivo AKI models induced by bilateral renal artery ischemia reperfusion and folic acid in mice. Ferroptosis induced by hypoxia and reoxygenation or erastin (Era) in mouse tubular epithelial cells (MTEC) was also rescued by melatonin treatment. RNA sequence analysis of ferroptosis-related genes showed that melatonin affects oxidative stress responses by inhibiting hypoxia and reoxygenation- (HR-) mediated downregulation of NRF2 and upregulation of Slc7a11 in MTEC. Specific knockdown of NRF2 increased the sensitivity of cells to ferroptosis, and melatonin failed to protect against ferroptosis in the HR condition. Together, our data indicate that melatonin prevents ferroptosis in AKI by acting on the NRF2/Slc7a11 axis.
[Retracted] Study on the Predictive Value of P53 Protein Expression in Brain Metastasis in NSCLC and the Mechanism of miR‐424 Reversing Platinum Resistance in NSCLC
Authors: Deng Yan , Duan Zhiwen , Luo Jie , Deng Wen , Liao Rongqing
Published: August 2022

In order to analyze the predictive value of P53 protein expression in brain metastases in NSCLC and the mechanism of miR‐424 reversing platinum resistance in NSCLC, a retrospective analysis is conducted in this study. Eighty‐two NSCLC patients who received relevant diagnosis and treatment in our hospital from September 2020 to September 2021 are chosen. The prognosis of the patients is observed, and the patients were divided into two groups according to the occurrence of BMS. The comparison of clinical baseline data and the expression of P53 protein and miR‐424 after surgery are performed. Furthermore, the predictive value of the P53 protein gene on the occurrence of BMS in NSCLC is analyzed by the ROC curve, and the expression of miR‐424 in serum of the patients before and after drug resistance is compared. The results demonstrate that the expression of P53 protein has a high predictive value for predicting the occurrence of BRAIN metastases in NSCLC patients. Also, the high expression of miR‐424 suggests that it is closely related to the occurrence of platinum resistance in NSCLC patients.
Chronic Cerebral Hypoperfusion Aggravates Parkinson’s Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism
Authors: Fan Yaohua , Li Mengzhu , Wu Chunxiao , Wu Yubiao , Han Jiajun , Wu Peipei , Huang Zifeng , Wang Qizhang , Zhao Lijun , Chen Dongfeng , Zhu Meiling
Published: August 2022

Chronic cerebral hypoperfusion (CCH) is a cardinal risk factor for Parkinson’s disease dementia (PDD), but this potential causality lacks mechanistic evidence. We selected bilateral common carotid artery occlusion (BCCAO) to simulate chronic cerebral hypoperfusion in the rat model of PD induced by typical neurotoxin 6-hydroxy dopamine (6-OHDA). Four weeks after unilateral injection of 6-OHDA into the medial forebrain bundle, rats underwent BCCAO. Male Sprague-Dawley rats were divided into five groups of ten, including sham, PD+BCCAO 2 weeks, PD+BCCAO 1 week, PD, and BCCAO 2 weeks. Then, open field test (OFT) and Morris water maze test (MWM) were used to assess the PDD-like symptoms in rats. Also, the pathological manifestations and mechanisms of BCCAO impairing cognitive functions have been explored via hematoxylin-eosin staining, Nissl staining, immunohistochemistry, immunofluorescence, RNA sequencing analysis, lipidomics, and quantitative real-time polymerase chain reaction. In this study, we found that CCH could aggravate PDD-like cognitive symptoms (i.e., learning memory and spatial cognition) and PDD-like pathology (higher expression of α-Syn and Aβ in prefrontal cortex and striatum). Moreover, a potential relationship between differentially expressed mRNAs and lipid metabolism was revealed by RNA sequencing analysis. Lipidomics showed that CCH could affect the intensity of 5 lipids, including sphingomyelin (SM 9:0;2O/26:2; SM 8:1;2O/25:0; and SM 8:0;2O/28:4), cardiolipin, lysophosphatidylcholine, cholesteryl ester, and triacylglycerol. Interestingly, the KEGG pathway analysis of both RNA sequencing analysis and lipidomics suggested that CCH leaded to learning impairment by affecting sphingolipid metabolism. Finally, we found that CCH disrupts the sphingolipid metabolism by affecting the mRNA expression of SMPD1 and SMS2, leading to the accumulation of sphingomyelin in the prefrontal cortex. In summary, CCH, an independent exacerbating reason for impairment in learning and memory within the pathopoiesis of PD, aggravates Parkinson’s disease dementia-like symptoms and pathology in 6-OHDA-lesioned rat through interfering with sphingolipid metabolism.
Influence of Self-Practice Oriented Teaching plus Psychological Intervention on Blood Glucose Level and Psychological State in Patients with Type 2 Diabetes Mellitus on Insulin Therapy
Authors: Li Xuefang , Ge Juan , He Lei
Published: August 2022

Background. The study aimed to examine the effect of self-practice oriented teaching plus psychological intervention on blood glucose level and psychological status of type 2 diabetic patients on first insulin therapy. Methods. A total of 80 patients with type 2 diabetes admitted from April 2020 to November 2020 were assessed for eligibility and included. They were then assigned to a control group and an observation group via the random number table method, with 40 cases in each group. In addition to insulin injection treatment in both groups prior to intervention, the control group received health education and psychological intervention, whereas the observation group adopted a self-practice oriented teaching strategy plus psychological intervention. Insulin injections, nursing satisfaction, blood glucose level, and disease awareness were compared between the two groups. The Exercise of Self-Care Agency (ESCA) scale was used to assess the patients’ self-care ability, the Generic Quality of Life Inventory-74 (GQOLI-74) scale was used to assess their quality of life, and the emotional state of patients was evaluated by the Hospital Anxiety and Depression (HAD) scale. Results. Patients in the observation group outperformed the control group in terms of insulin injection after intervention (

P
<
0.05

). Significantly higher nursing satisfaction and ESCA scores were observed after intervention (

P
<
0.05

). Self-practice oriented teaching plus psychological intervention resulted in remarkably lower postintervention glycemic indexes (

P
<
0.001

). Markedly higher disease knowledge scores and GQOLI-74 scores were witnessed in the observation group in contrast to those of the control group (

P
<
0.001

). The observation group patients showed lower HAD scores than those of the control group (

P
<
0.001

). Conclusion. Self-practice oriented teaching plus psychological intervention could effectively alleviate the negative emotions of type 2 diabetic patients on first insulin therapy, stabilize glycemic indexes, and improve quality of life, demonstrating good potential for clinical promotion.
Trajectory Clustering in an Intersection by GDTW
Authors: Gao Lei , Wei Lu , Yang Jian , Li Jinhong
Published: August 2022

GPS trajectory data in intersections are series data with different lengths. Dynamic time wrapping (DTW) is good to measure the similarity between series with different lengths, however, traditional DTW could not deal with the inclusive relationship well between series. We propose a unified generalized DTW algorithm (GDTW) by extending the boundary constraint and continuity constraint of DTW and using the weighted local distance to normalize the cumulative distance. Based on the density peak clustering algorithm DPCA using asymmetric GDTW to measure the similarity of two trajectories, we propose an improved DPCA algorithm (ADPC) to adopt this asymmetric similarity measurement. In experiments using the proposed method, the number of clusters is reduced.
Procedural Efficiency, Efficacy, and Safety of High-Power, Short-Duration Radiofrequency Ablation Delivered by STSF Catheter for Paroxysmal Atrial Fibrillation
Authors: Cheng Cheng , Xu Banglong , Sheng Jianlong , Huang Zheng , He Fei , Gao Feng , Wang Xiaochen
Published: August 2022

Objectives. To investigate the procedural efficiency, efficacy, and safety of high-power, short-term radiofrequency ablation delivered by the SmartTouch Surround Flow (STSF) catheter for paroxysmal atrial fibrillation (AF). Methods. We retrospectively analyzed a total of 72 patients who were admitted with paroxysmal AF, and who underwent radiofrequency catheter ablation (RFCA) for the first time. Of these patients, 36 cases underwent low-power, long-duration (LPLD, (30–35 W/20–40 s) pulmonary vein isolation (PVI) delivered by an SmartTouch (ST) catheter (control group), and the other 36 cases underwent high-power, short-duration (HPSD, (45–50 W/10–20 s) PVI delivered by a STSF catheter (study group). The baseline data, duration of PVI, procedural time, fluoroscopy time, the rate of first-pass isolation, irrigation perfusion, eschar and steam pop occurrences, intraoperative complications, and the rate of stable sinus rhythm maintenance following a blanking period of three months were analyzed between the two groups. Results. The isolation time of bilateral PVI and procedural time in the study group were markedly less than in controls (

p
<
0.01

). The rate of first-pass isolation in the study group was significantly higher than in the control group (95.8% vs. 84.7%,

p
=
0.023

), while the fluid perfusion in the study group was approximately 20% less than that in the control group (767 ± 171 vs. 966 ± 227 ml,

p
<
0.001

). We observed no severe complications in any patients. The rate of freedom from AF recurrences following a blanking period of three months showed a tendency to be higher than in controls (93.9% vs. 87.1%,

p
=
0.348

). Conclusions. The HPSD strategy delivered by the STSF catheter was superior to conventional LPLD ablation through the ST catheter with respect to efficiency, acute procedural effectiveness, short-term safety, and the risk of heart failure in patients with paroxysmal AF.
Optimizing the Mechanical and Microstructure Characteristics of Stir Casting and Hot-Pressed AA 7075/ZnO/ZrO2 Composites
Authors: Satishkumar P. , Saravana Murthi C. , Chebolu Rohinikumar , Rao Yenda Srinivasa , Capangpangan Rey Y. , Alguno Arnold C. , Yadav Vishnu Prasad , Chitra M. , Gopal Mahesh
Published: August 2022

The composite was made using the stir cast manufacturing method. Many parameters, like stirring speed, stirring time, ZrO2% reinforcement, and cast temperature, are evaluated in a Taguchi experimental design to see how they affected the composite properties. In terms of composite properties, ZrO2% reinforcement and the stir speed have the most significant impact. There were 25.02% gains in ultimate tensile strength and hardness, as well as a decrease in composite wear loss, when the optimal stir casting parameters were used compared to the initial stir casting settings. To get insight into the process and the qualities of the composite, the hot-pressing parameters were studied. Pressure, followed by temperature, is the most critical factor in determining the properties of composites. When a hot-pressing setting was determined to reduce the wear loss by a significant 39.3%, it was deemed perfect by the superranking concept. Under ideal conditions, hot-pressing procedures reduced wear loss by 40.8% while boosting ultimate tensile strength and hardness by 19.83% and 9.6%, respectively. The resulting microstructures and worn surface morphologies from stir casting and hot pressing show vastly different properties.
Diagnostic and Therapeutic Roles of Extracellular Vesicles in Aging-Related Diseases
Authors: Sun Zixuan , Hou Xiaomei , Zhang Jiaxin , Li Jiali , Wu Peipei , Yan Lirong , Qian Hui
Published: August 2022

Aging shows a decline in overall physical function, and cellular senescence is the powerful catalyst leading to aging. Considering that aging will be accompanied with the emergence of various aging-related diseases, research on new antiaging drugs is still valuable. Extracellular vesicles (EVs), as tools for intercellular communication, are important components of the senescence-associated secretory phenotype (SASP), and they can play pathological roles in the process of cellular senescence. In addition, EVs are similar to their original cells in functions. Therefore, EVs derived from pathological tissues or body fluids may be closely related to the progression of diseases and become potential biomarkers, while those from healthy cells may have therapeutic effects. Moreover, EVs are satisfactory drug carriers. At present, numerous studies have supported the idea that engineered EVs could improve drug targeting ability and utilization efficiency. Here, we summarize the characteristics of EVs and cellular senescence and focus on the diagnostic and therapeutic potential of EVs in various aging-related diseases, including Alzheimer disease, osteoporosis, cardiovascular disease, diabetes mellitus and its complications, and skin aging.
Contribution of Patch Tests with Occupational Handled Products in the Diagnosis of Occupational Contact Dermatitis: A 10‐year Review
Authors: Aloui A. , Maoua M. , El Guedri S. , Moussa A. , Bouhoula M. , Chouchene A. , Kacem I. , Brahem A. , Ghariani N. , Kalboussi H. , El Maalel O. , Chatti S. , Denguezli M. , Mrizek N.
Published: August 2022

Introduction. Allergic contact dermatitis (ACD) is a common occupational disease. Its diagnosis is essentially based on interrogation and patch tests. However, commercially available batteries are sometimes not appropriate for the working conditions and the handled products, which must then be tested. In Tunisia, no previous study has focused on the contribution of patch tests with handled products in the workplace. The objective of this study is to establish the sociodemographic and occupational profile of the patients benefiting from patch tests with handled products in the workplace to identify the characteristics of these products as well as to evaluate the relevance of their positivity and their contributions in terms of aetiological diagnosis of occupational ACD. Methods. This is a retrospective descriptive epidemiological study conducted for a period of 10 years from January 1st, 2006, to December 31, 2015, among patients exercising a professional activity and consulting the Dermato‐Allergology Unit of the Occupational Medicine ward of the University Hospital Farhat Hached of Sousse for the exploration of ACD. Results. During the study period, 113 patients received patch tests of handled products in the workplace with a prevalence of 7.3% of patch‐tested patients during the same period. The mean age was 35.79 ± 9.45 years with a male predominance (sex ratio = 1.35). The most represented activity sectors were the health sector in 30.1% and the textile sector in 21.2%. The majority of patients were professionally active (61.9% of the study population) with an average professional seniority of 10.28 ± 8.49 months. In total, 138 patch tests with handled products were carried out of which 46 tests were positive (33.3%). After the analytical study, variables independently significantly associated with the positivity of patch tests with handled products in the workplace were the male gender and the working in the plastics industry. An occupational disease was declared to the National Health Insurance Fund for 8 patients, i.e., 7.1% of cases. Conclusion. Patch tests with handled products in the workplace can provide strong arguments for the professional origin of the ACD.
[Retracted] Analysis on the Impact and Management of Political Education of College Students in the Micro Era Environment
Authors: Li Li , Li Wei
Published: August 2022

With the rapid development of modern society and the popularization of information equipment, information transmission has broken the time and space constraints, and political education (PE) can be carried out anytime and anywhere. Micro media is the product of the rapid development of science and technology, which has brought us into a new “micro era.” The research on the “micro era” has been the focus of academic attention in recent years. Especially with the popularization of micro media, its influence on people is becoming deeper, making more scholars in academic circles devote themselves to the “micro era” under study. However, while micro media is widely used by college students (CS), it also brings opportunities and challenges. Therefore, it is particularly important to clarify the opportunities and challenges faced by CS’ PE under the background of the “micro era” and put forward practical countermeasures. Starting from the actual situation of PE communication in the micro era, this study analyzes the opportunities and challenges brought by the “micro era” to PE of CS through a questionnaire survey. Then, the effective strategies to improve the PE of CS are explored, in order to improve the ideological and political level of CS in the micro era.
Mathematical Modeling and Simulation of Online Teaching Effect Evaluation Based on Decision Tree Algorithm
Authors: Sun Pingli
Published: August 2022

With the support of big data technology, the field of education is also facing new problems and opportunities. Network teaching has become the mainstream means of higher education. In order to explore the changes of students’ learning effect in the process of online teaching, this paper proposes to build an online teaching effect evaluation model with the support of data mining technology and decision tree algorithm. This paper records the factors and objects that reflect the teaching effect in network teaching and traditional teaching, respectively. A decision tree algorithm is used to divide the attributes of influencing factors from relevant rules. Using the Kirschner model to build the evaluation system, add two attribute elements: students’ teaching evaluation and teachers’ self-evaluation. Data mining technology is used to preprocess and clean up the sample set, which improves the accuracy of the calculation results. In the evaluation model, the association rule algorithm is also constructed to classify the data of the same element type and delete the data of different elements after marking. Through this evaluation model, teachers can accurately judge students’ learning interests and improve students’ academic performance. The results show that compared with the traditional data mining algorithm, the decision tree algorithm has obvious advantages in computing speed and accuracy.
A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene
Authors: Girmay Shishay , Ahmad Hafiz Ishfaq , Zahra Quratul Ain
Published: August 2022

Leptin is a polypeptide hormone produced in the adipose tissue and governs many processes in the body. Recently, polymorphisms in the LEP gene revealed a significant change in body weight regulation, energy balance, food intake, and reproductive hormone secretion. This study considers its crucial role in the regulation of the economically important traits of sheep. Several computational tools, including SIFT, Predict SNP2, SNAP2, and PROVEAN, have been used to screen out the deleterious nsSNPs. Following the screening of 11 nsSNPs in the sheep genome, 5 nsSNPs, T86M (C → T), D98N (G → A), N136T (A → C), R142Q (G → A), and P157Q (C → A), were predicted to have a significant deleterious effect on the LEP protein function, leading to phenotypic difference. The analysis of proteins’ stability change due to amino acid substitution using the I‐stable, SDM, and DynaMut consistently confirmed that three nsSNPs (T86M (C → T), D98N (G → A), and P157Q (C → A)) increased protein stability. It is suggested that these three nsSNPs may enhance the evolvability of LEP protein, which is vital for the evolutionary adaptation of sheep. Our findings demonstrate that the five nsSNPs reported in this study might be responsible for sheep’s structural and functional modifications of LEP protein. This is the first comprehensive report on the sheep LEP gene. It narrow downs the candidate nsSNPs for in vitro experiments to facilitate the development of reliable molecular markers for associated traits.
Changes of Serum D-Dimer, NT-proBNP, and Troponin I Levels in Patients with Acute Aortic Dissection and the Clinical Significance
Authors: Xu Zexiang , Wei Meiyu , Guo Xin , Zhang Qing , Ma Yankun , Gao Zhisheng , Teng Zhen
Published: August 2022

Objective. To investigate the changes in blood D-dimer (D-D), high-sensitivity troponin I (hs-cTnI), and N-terminal B-type brain natriuretic peptide (NT-proBNP) levels in patients with acute aortic dissection (AAD) and its clinical significance. Methods. Forty patients with AAD diagnosed in our hospital from January 2018 to December 2019 were selected as the observation group, and 40 patients with chest pain and non-AAD treated in our hospital during the same period were included in the control group. The patients were subdivided into a death group and a survival group as per the prognosis. The clinical symptoms and signs of the two groups of patients upon admission were observed, and the levels of D-D, hs-cTnI, and NT-proBNP were determined. The differences in clinical data, plasma D-D, hs-cTnI, and NT-proBNP levels between the two groups of patients were analyzed. Results. The clinical data and physical signs were homogeneous between the two groups (

P
>
0.05

), while a significant elevation in the level of hs-cTnI in the control group was observed 24 h after admission (

P
<
0.05

). The observation group showed significantly higher levels of D-D, NT-proBNP, and hs-cTnI than the control group (

P
<
0.05

). The prevalence and surgical cure rate of Stanford A in the survival group were significantly lower in contrast with the death group, with an obvious higher intervention cure rate in the survival group. Higher D-dimer and NT-proBNP levels were identified at 24 h after admission versus upon admission, and the death group had a greater increase of D-dimer and NT-proBNP levels. Conclusion. Clinical symptoms and signs are insufficient to constitute a diagnosis of AAD, whereas the elevated expression levels of D-D, hs-cTnI, and NT-proBNP demonstrated great potential for the diagnosis and prognosis of AAD.
Lightweight Multireceptive Field CNN for 12-Lead ECG Signal Classification
Authors: Feyisa Degaga Wolde , Debelee Taye Girma , Ayano Yehualashet Megersa , Kebede Samuel Rahimeto , Assore Tariku Fekadu
Published: August 2022

The electrical activity produced during the heartbeat is measured and recorded by an ECG. Cardiologists can interpret the ECG machine’s signals and determine the heart’s health condition and related causes of ECG signal abnormalities. However, cardiologist shortage is a challenge in both developing and developed countries. Moreover, the experience of a cardiologist matters in the accurate interpretation of the ECG signal, as the interpretation of ECG is quite tricky even for experienced doctors. Therefore, developing computer-aided ECG interpretation is required for its wide-reaching effect. 12-lead ECG generates a 1D signal with 12 channels among the well-known time-series data. Classical machine learning can develop automatic detection, but deep learning is more effective in the classification task. 1D-CNN is being widely used for CVDS detection from ECG datasets. However, adopting a deep learning model designed for computer vision can be problematic because of its massive parameters and the need for many samples to train. In many detection tasks ranging from semantic segmentation of medical images to time-series data classification, multireceptive field CNN has improved performance. Notably, the nature of the ECG dataset made performance improvement possible by using a multireceptive field CNN (MRF-CNN). Using MRF-CNN, it is possible to design a model that considers semantic context information within ECG signals with different sizes. As a result, this study has designed a multireceptive field CNN architecture for ECG classification. The proposed multireceptive field CNN architecture can improve the performance of ECG signal classification. We have achieved a 0.72

F

1

score and 0.93 AUC for 5 superclasses, a 0.46

F

1

score and 0.92 AUC for 20 subclasses, and a 0.31

F

1

score and 0.92 AUC for all the diagnostic classes of the PTB-XL dataset.
Research on the Characteristics of Coal Bump and Monitoring and Early Warning in Hujiahe Coal Mine
Authors: Yu Fei , Zhang Tong , Wei Zhen
Published: August 2022

Under the high intensity mining disturbance, coal bump is easily triggered by the sudden release of large amount of elastic energy contained in the coal body, which seriously affects coal mine safety production. Triaxial experiments were used to study the damage characteristics of coal samples subjected to loading at the 401103 working face of Hujiahe coal mine, and the critical value of peak strength of coal samples was investigated. Based on the characteristics of the mechanical damage behavior of coal samples obtained from the triaxial experiment, the statistics of the occurrence of coal bump events at the 401103 working face were conducted through numerical simulation and field monitoring to study the areas that need to be focused on prevention and control, with a view to providing basic research for deep coal mining. The results show the following: (1) the strength of coal samples is “weakened” by stress loading, and the fracture penetrates the coal body interface leading to the formation of tensile-shear damage of coal samples. The value of the damage variable for the coal sample in the initial damage stage is 0; at the damage stabilization stage, the values of damage variables were derived to be located at 0.03~0.14. The bearing capacity of the coal sample decreases rapidly during the accelerated development period. (2) According to the simulation and field monitoring, it is known that 0~100 m in front of the coal mining face belongs to the key monitoring area. (3) With the advancement of the working face, different coal pillar widths have obvious effects on the vertical stress, and stress increase and decrease zones appear on both sides of the coal column, and the peak stress shows the characteristics of increasing first and then decreasing with the advancement of the working face. The width of the working face has a great influence on the change of vertical stress. When the sensitivity of the vertical stress to the width of the working face increases, the stress concentration phenomenon will occur, and a large amount of elastic energy gathered in the coal body is suddenly released to induce coal bump.
Construction of Underground 3D Visualization Model of Mining Engineering Based on Shear-Warp Volume Computer Rendering Technology
Authors: Qu Nianhua , Yan Yubiao , Cheng Tong , Li Tao , Wang Yajun
Published: August 2022

In view of the complexity of mine geology, complex mountain structure, and strong concealment characteristics, the construction of 3D visual model of mining engineering is of great significance for mine mining design, production, and residual ore remining. Based on the comprehensive analysis of the development results of the existing 3D visualization software of ore body at home and abroad and the actual needs of domestic mines, this paper determines the key technologies and solutions to be studied. Focusing on the overall goal of real ore body visualization, relying on geology, mining, computer graphics CAD technology, and computer software engineering develops a set of 3D visual modeling general components for 3D simulation software developers to realize the 3D visual operation platform of ore body with independent intellectual property rights. By introducing the Shear-Warp volume computer rendering technology into the underground 3D visualization analysis process of mining engineering, a three-layer visualization platform structure based on hierarchical model is designed from the perspective of software engineering, which effectively strengthens the low coupling of data and high cohesion of function of the system. The example analysis results show that this method can accurately simulate the 3D structure and distribution of the actual ore body and make basic preparations for reserve estimation, mining design, mining development, and prospecting prediction. At the same time, the general component of 3D visual modeling provided by the system is ready for the interface of 3D simulation involved in mining software development.
Delicaflavone Represses Lung Cancer Growth by Activating Antitumor Immune Response through N6-Methyladenosine Transferases and Oxidative Stress
Authors: Wang Xuewen , Xu Dafen , Chen Bing , Huang Dandan , Li Zhijun , Sui Yuxia , Lin Fei , Yao Hong , Li Huang Yuan , Lin Xinhua
Published: August 2022

Our previous studies have shown that delicaflavone (DLL), a biocomponent extracted from Selaginella doederleinii Hieron, has antitumor activity. However, the role of DLL in the antitumor immune response is unknown. In this study, we tested the potential roles of DLL in antitumor immune response. An animal tumor model with Lewis lung cancer cell line (3LL) in C57BL/6 mice was established to determine whether DLL induced the tumor-bearing host’s antitumor immune response. m6A-MeRIP-qPCR, western blot, and flow cytometry were performed to explore the underlying mechanisms. DLL inhibited the proliferation of 3LL lung cancer cells in vitro and in vivo and induced tumor cell oxidative stress. DLL significantly inhibited tumor growth in immunocompetent mice compared with nude mice. DLL treatment significantly increased Th1 cytokine production and CD8+ T cell infiltration into tumor tissues in tumor-bearing mice. DLL-mediated antitumor immune effects were reversed by overexpression of the N6-methyladenosine (m6A) transferase Mettl3/Mettl14. Mechanistically, DLL upregulated the expression of Stat1 and Irf1 and the secretion of cytokines by inhibiting Mettl3 and Mettl14 in lung cancer cells. In conclusion, DLL inhibited lung cancer cell growth by suppressing Mettl3/Mettl14 to activate antitumor immunity. These findings provided an opportunity to enhance lung cancer immunotherapy.
Effect of Fragmentation on Pore Structures and Fractal Characteristics of Intact Coal and Deformed Coal Based on Experiments
Authors: Li Mingjie , Lu Shouqing , Wang Chengfeng , Liu Jie , Shi Jiang , Bei Taibiao
Published: August 2022

Coal mining has to develop to deeper strata with the increasing demand for coal, which leads to frequent coal and gas outburst disasters. Especially, when there is a deformed coal in the coal seam, the outburst disasters are easier and more intense. Coal and gas outburst disasters can be promoted by the fragmentation. In order to clearly explain the reasons for the impact of fragmentation on deformed coal and gas outburst, mercury intrusion porosimetry, low-temperature liquid N2 adsorption test, and scanning electron microscope were carried out in this paper. The differences in pore characteristics of intact coal and deformed coal under different particle size conditions were analyzed from pore shapes, pore size distributions, and fractal dimensions. The damage paths of fragmentation on various kinds of pores in intact coal are as follows: macropores, mesopores, minipores, and micropores, and those on various kinds of pores in deformed coal are as follows: macropores, micropores, mesopores, and minipores. According to the fractal dimension theory and experimental results, the calculative results of fractal dimensions show that the fragmentation and tectonism reduce the surface roughness and structural complexity of macropores and mesopores and increase those of minipores and micropores in deformed coal. Finally, combined with the coupling effect of fragmentation and tectonism on pores, the reason of deformed coal with high crushing degree in fields of outburst was explained. The research provides the basis for the prevention of coal and gas outburst.
Motion Trajectory Planning and Design of Material Spraying Service Robot
Authors: Wang Gang , Wen Hongyuan , Feng Jun , Zhou Jun
Published: August 2022

The application of robots reduces repetitive and dangerous tasks for humans, especially the spraying robot, because many spraying materials are corrosive, toxic, and harmful. This paper designs the motion trajectory planning of the material spraying service robot. With the increasing demand for technology, there are strict requirements for the uniformity and thickness of spraying. In view of this, this paper proposes an algorithm for modeling kinematics using a joint screw and optimizes the modeling algorithm using particle swarm optimization. This makes the industrial spraying robot more intelligent and more capable of completing high-standard tasks. The experimental results in this paper show that when the spraying radii on the large-curvature cone surface are 44.5 and 49.5 mm, respectively, the coating distribution in the intersection area of the curved surfaces can be well controlled, and the optimized algorithm can better plan the path of the spraying robot.
circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis
Authors: Kang Kai , Li Nana , Gao Yang , Wang Changsong , Chen Pengfei , Meng Xianglin , Yang Wei , Zhao Mingyan , Yu Kaijiang
Published: August 2022

Background. Sepsis is a systemic inflammatory response that can elicit organ dysfunction as well as circulatory diseases in serious cases. When inflammatory responses are especially dysregulated, severe complications can arise, including sepsis-induced liver injury. Various microRNAs along with circular (circ) RNAs are involved in inflammatory responses; nevertheless, their functions in regulating sepsis-induced liver injury remain unknown. The cecal ligation and puncture (CLP) procedure can induce liver injury as well as polymicrobial sepsis. Methods. In this study, CLP was used to induce liver injury as well as polymicrobial sepsis. Then, liver function, inflammatory cytokine expression, and hepatic histopathology were evaluated. High-throughput sequencing was employed to investigate the abnormal hepatic circRNA expression after CLP. Raw264.7 cells were utilized to simulation an in vitro sepsis inflammation model with LPS induce. The relative mRNA as well as protein levels of TNF-α, IL-1β, and IL-6 was explored by quantitative polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays. We explored functional connections among circRNAs, miR-31-5p, and gasdermin D (GSDMD) using dual-luciferase reporter assays. Western blot was employed to test GSDMD, caspase-1, and NLRP3 expression in mice and cell models. Results. Our results showed that CLP-induced sepsis promoted liver injury via increasing inflammatory pyroptosis. The abnormal expression of circ-Katnal1 played an important role in CLP-induced sepsis. Downregulating circ-Katnal1 suppressed LPS-induced inflammatory pyroptosis in Raw264.7 cells. Bioinformatics and luciferase reporter results confirmed that miR-31-5p and GSDMD were downstream targets of circ-Katnal1. Inhibiting miR-31-5p or upregulating GSDMD reversed the protective effects of silencing circ-Katnal1. Conclusion. Taken together, circ-Katnal1 enhanced inflammatory pyroptosis in sepsis-induced liver injury through the miR-31-5p/GSDMD axis.
[Retracted] Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF‐KB Signaling Pathway
Authors: Shi Qiangyou , Shen Xueliang , Long Chao , Guo Fan , Mi Zhipeng , Li Yongchun , Ma Ruixia
Published: August 2022

Allergic rhinitis is one of the common chronic inflammatory diseases of the nasal mucosa. In order to investigate the effect of zinc on ovalbumin induced allergic rhinitis in BALB/C male mice based on NF‐KB signaling pathway, thirty BALB/C male mice are randomly divided into three groups: control group, ovalbumin induced allergic rhinitis asthma group and zinc intervention group. The experimental results show that Zinc supplementation in allergic asthma mice with allergic rhinitis correct the immune response of TH2 cells by inhibiting THE NF‐KB signaling pathway, reduce the infiltration of inflammatory cells into lung nasal tissue, and reduce airway co‐hyperreactivity to improve the clinical symptoms of asthma and play an immune protective role.
Damage‐Tolerant Woven Glass Fiber Composites Developed Using Polyvinyl Butyral (PVB) Unsaturated Polyester (UP) Blends
Authors: Ali Muhammad Faizan , Hussain Muzzamal , Tariq Asra , Ahmed Hassan Iftekhar , Shahid Salma , Saouab Abdelghani , Nawab Yasir
Published: August 2022

The thermoset matrix is brittle and shows low damage characteristics, and their impact and damage performance can be improved significantly by blending with the thermoplastic matrix. In this way, the properties of both the matrices can be gathered in one composite. This study is focused on the development and optimization of novel blends of unsaturated polyester (UP) resin with polyvinyl butyral (PVB), a thermoplastic polymer, to improve the mechanical properties, especially delamination and impact behavior of associated glass fiber composites. The five blends of UP and PVB were prepared in different concentrations by the solution mixing method. Composite samples of woven glass fabric were fabricated using prepared blends and pure resins as matrices on compression molding. Tensile, flexural, T-peel tests, and the instrumented Charpy impact tests were conducted on the developed samples. A significant improvement in the impact energy absorption (102%) and delamination resistance (110%) was observed for a blend ratio of 40 : 60 and 50 : 50 of PVB : UP, respectively, as compared to pure UP composite samples.
Resilient Public Transport Construction in Mega Cities from the Perspective of Ecological Environment Governance
Authors: Ge Wenjing , Zhang Guixiang
Published: August 2022

With the rapid development of the social economy, environmental and resource constraints of economic growth are becoming more and more serious. Therefore, for cities, we should take the road of green development and sustainable development. On the one hand, we should fully implement the basic policies issued by the central government. On the other hand, we should fully integrate the actual situation of the city to make it better implemented, which will help to improve the ability of ecological environment governance and consolidate the ecological advantages of the city. With the development of the urban economy and the continuous increase of population, the development pressure faced by cities is also increasing. Innovating urban construction mode has increasingly become the focus of the development of the new era. The main reason is that the continuous growth of the urban population, environmental pollution, traffic congestion, and ecological damage has caused great trouble to urban residents. The traditional public service governance model has been unable to meet the current public service needs of urban residents. Based on this background, major cities around the world have begun to study urban resilience in order to prevent and resist the interference and impact brought by the outside world and maintain the sound development of the urban system. Based on the demand for ecological environment governance, this study analyzes the current situation and causes of urban ecological environment governance in China and the problems existing in urban resilient transportation construction in China, and puts forward corresponding countermeasures for ecological environment governance and the current situation of urban resilient public transportation construction. This study has great theoretical and practical significance to promote the sustainable development of the Chinese ecological environment and the resilience construction of urban transportation.
Superfield Approaches to a Model of Bosonic String: Curci-Ferrari-Type Restrictions
Authors: Tripathi A. , Rao A. K. , Malik R. P.
Published: August 2022

Exploiting the theoretical potential of the modified Bonora-Tonin superfield approach (MBTSA) as well as the (anti-)chiral superfield approach (ACSA) to Becchi-Rouet-Stora-Tyutin (BRST) formalism, we derive the complete set of off-shell nilpotent (anti-)BRST symmetry transformations corresponding to the classical two-

1
+
1

dimensional (2D) diffeomorphism symmetry transformations on the worldsheet (that is traced out by the motion of a model of bosonic string). Only the BRST symmetry transformations for this model have been discussed in the earlier literature. We derive the (anti-)BRST invariant Curci-Ferrari- (CF-) type restrictions (using MBTSA) which turn out to be the root cause behind the absolute anticommutativity of the above (anti-)BRST symmetry transformations. We capture the symmetry invariance of the (anti-)BRST invariant Lagrangian densities within the ambit of ACSA. The derivation of the proper anti-BRST transformations (corresponding to the already-known BRST transformations) and the (anti-)BRST invariant CF-type restrictions are the novel results in our present endeavor.
Application Value of Nursing Intervention under the Guidance of Risk Prevention Management Concept in Preventing Vascular Access Infection in Patients Undergoing Maintenance Hemodialysis
Authors: Wan Huijuan , Tang Dongxing
Published: August 2022

Objective. To explore the application value of nursing intervention under the guidance of risk prevention management concept in preventing vascular access infection in patients undergoing maintenance hemodialysis (MHD). Methods A total of 100 MHD patients who were admitted to the intensive care unit (ICU) of our hospital from May 2019 to May 2020 were enrolled. Based on the principle of double-blind grouping, patients were randomly divided into the risk management group and control group, with 50 cases in each group. The control group was given routine nursing, while the risk management group was given nursing intervention under the guidance of risk prevention management concept on the basis of the control group. The nursing intervention effect and incidence of vascular access infection were compared between the two groups. The psychological status and quality of life in both the groups were evaluated by the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and Short Form 36 Health Survey (SF-36). Results After intervention, biochemical indexes (serum albumin, creatinine, and hemoglobin) and body mass in the risk management group were significantly higher than those in the control group, while malnutrition-inflammation score (MIS) was significantly lower than the control group (

P
<
0.05

). After intervention, SAS and SDS scores in both the groups were significantly decreased, which were significantly lower in the risk management group than in the control group (

P
<
0.05

). At 8 w and 12 w after intervention, incidence rates of vascular access infection in risk management group were significantly lower than those in the control group (10.00% vs. 26.00% and 12.00% vs. 34.00%,

P
<
0.05

). After intervention, SF-36 scores in each dimension of both the groups were significantly increased, which were significantly higher in the risk management group than in the control group (

P
<
0.05

). Conclusion The implementation of nursing intervention under the guidance of risk prevention management concept for MHD patients can effectively improve biochemical indexes, nutritional status, and body mass and reduce the incidence of vascular access infection, which is of great significance for improving psychological status and quality of life.
Quasi-One-Dimensional Model of Hydrocarbon-Fueled Scramjet Combustor Coupled with Regenerative Cooling
Authors: Xiong Yuefei , Qin Jiang , Cheng Kunlin , Zhang Silong , Feng Yu
Published: August 2022

In order to rapidly predict the performance of hydrocarbon-fueled regeneratively cooled scramjet engine in system design, a quasi-one-dimensional model has been developed. The model consists of a supersonic combustor model with finite-rate chemistry and a cooling channel model with real gas working medium, which are governed by two sets of ordinary differential equations separately. Additional models for wall friction, heat transfer, sonic fuel injection, and mixing efficiency are also included. The two sets of ordinary differential equations are coupled and iteratively solved. The SUNDIALS code is used since the equations for supersonic combustion flow are stiff mathematically. The cooling channel model was verified by electric heating tube tests, and the supersonic combustor model was verified by experimental results for both hydrogen and hydrocarbon-fueled scramjet combustors. Three cases were comparatively studied: (1) scramjet combustor with an isothermal wall, (2) scramjet combustor with an adiabatic wall, and (3) scramjet combustor with regenerative cooling. Results showed that the model could predict the axial distributions of flow parameters in the supersonic combustor and cooling channel. Differences on ignition delay time and combustion efficiency for the three cases were observed.