bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel prognostic Potential of Early Second Trimester and Mid-pregnancy 8-hydroxy-2-deoxyguanosine/Placental growth factor ratio for preeclampsia: A Longitudinal Nested-Case Control Study
Authors: Anto Enoch , Coall David , Wiafe Yaw , Addai-Mensah Otchere , Turpin Cornelius , Tawiah Augustine , Owiredu WKBA , Obirikorang Christian , Adua Eric , Annani-Akollor Max , Sakyi Samuel , Fondjo Linda , Acheampong Emmanuel , Adu Evans , Afrifa-Yamoah Ebenezer , Wang Xueqing , Wang youxin , Wang wei
Published: March 2022

Objective The study used both subjective, Suboptimal Health Status (SHS)
concept along with objective, biomarkers of oxidative stress (OS):
8-OHdG, 8-epi-PGF2α and total antioxidant capacity (TAC); and angiogenic
growth mediators (AGMs): VEGF-A, sFlt-1, PlGF and soluble endoglin
(sEng) for predicting early-onset (EO) and late-onset (LO) preeclampsia
(PE) Design A hospital-based longitudinal nested case-control study
Setting Obstetrics and Gynaecology Department at Komfo Anokye Teaching
Hospital, Ghana Population/Sample Singleton normotensive pregnancies
(NTN-P) at baseline W1 (10-20th week gestation) (n= 593) of which 498
(197 developed PE) completed the study. Methods: The overall health
status of the NTN-P participants was assessed at W1 and categorised as
SHS and optimal health status (OHS) using a validated SHS
questionnaire-25. Participants were followed at W2 (21-31st week,
mid-pregnancy) and 32-42nd week. Samples were collected and analysed for
biomarkers of OS and AGMs at the three-time points. Main Outcome
Measures Receiver operative characteristics curve analysis was performed
for the single and combined W1 and W2 biomarkers of OS and AGMs for
predicting PE and its subtypes (EO-PE and LO-PE) Results Compared to
single biomarkers of OS and AGMs, their combined ratios particularly,
the W2 8-OHdG/PIGF ratio was a potent biomarker for PE [AUC=0.93].
Additionally, 8-OHdG/PIGF ratio best identified SHS-pregnant women who
later developed EO-PE [AUC=0.97] and LO-PE [AUC=0.93]. Moreover,
8-OHdG/PIGF ratio best identified OHS-pregnant women who later developed
EO-PE [AUC=0.94] and LO-PE (AUC=0.94). Conclusion Combination of
biomarkers of OS and AGMs, particularly, mid-pregnancy 8-OHdG/PlGF ratio
is a potent biomarker for PE and its subtypes.
Comparison of either separated or combined intranasal dexmedetomidine and oral midazolam on anesthesia inhalation induction in children
Authors: cai yuhang , wang chengyu , li yang , chen jia , li jun , wu junzheng , Liu huacheng
Published: March 2022

Abstract Background and Purpose: Anesthetic inhalation induction could
be one of the most stressful experiences for children. While, either
oral midazolam or nasal dexmedetomidine as premedication remains less
than ideal. This study was to assess the efficacy and safety when those
two premeds were applied together in children undergoing minor
surgeries. Experimental Approach: One hundred and thirty-eight children
aged 2-6 years old were randomly allocated into three equal groups based
on the premedication routes: Group M with oral midazolam 0.5 mg.kg-1,
Group D with intranasal dexmedetomidine 2 μg.kg-1 and Group MD with
intranasal dexmedetomidine 1 μg.kg-1 plus oral midazolam 0.5 mg.kg-1,
respectively. The primary outcome was the satisfactory compliance rate
during inhalation induction with sevoflurane using induction compliance
checklist. The secondary outcomes were the preoperative m-YPAS scores
when the children arrived in the holding area, sedation level, behavior
scores, parental separation anxiety scores, mask acceptance scale (MAS),
the incidence of emergence agitation, recovery time and other adverse
events. Key Results: Subjects in Group MD showed higher satisfactory
compliance rate (n=38, P=0.0049) and satisfactory MAS (n=38, P=0.0049)
on anesthesia inhalation induction. Compared to the Group M and D,
Subjects in Group MD had significantly shorter onset time to achieve the
satisfactory sedation level (P<0.001) and higher sedation
score at 20 and 30min after drug administration (P<0.001).
Conclusion and Implications: We conclude that combined intranasal
dexmedetomidine 1μg.kg-1 and oral midazolam 0.5 mg.kg-1 significantly
improved the compliance during inhalation induction with sevoflurane,
and had quicker onset to reach satisfactory sedation level in children.
Complement mediated hemolysis in a child with COVID-19 infection
Authors: Şahin Seda , bayhan turan , Bayhan Gülsüm İclal , Yarali Nese
Published: March 2022

The novel coronavirus disease 2019 (COVID-19) is a member of Beta
coronaviruses that became pandemic by March of 2020. The hematological
manifestations related to COVID-19 are mostly lymphopenia,
thrombocytopenia, elevated D-dimer, and ferritin levels. Autoimmune
hemolytic anemia (AIHA) associated with COVID-19 has been described
rarely; however, to our knowledge, complement-mediated autoimmune
hemolytic anemia (CM-AIHA) has not been reported in children. Here, we
report a child with COVID-19 associated with CM-AIHA.
Super-dosed butyrate induces a revisable metabolic paralysis through transient mitochondrial reprogramming in the gut-brain axis
Authors: Xu Yanhong , Peng Shiqiao , Cao Xinyu , Qian Shengnan , Shen Shuang , Luo Juntao , Zhang Xiaoying , Sun Hongbin , Shen Wei , Jia Weiping , Ye Jianping
Published: March 2022

Background and purpose Sodium butyrate (SB) is a major product of gut
microbiota with signaling activity in the human body. However, the toxic
effect of SB remains largely unknown. This issue is addressed in current
study. Experimental approach SB (0.3 – 2.5 g/kg) was administrated
through a single peritoneal injection in mice. The core body temperature
and mitochondrial function in the brain hypothalamus were monitored.
Pharmacodynamics, targeted metabolomics, electron microscope, oxygen
consumption rate and gene knockdown were employed to dissect the
mechanism for the toxic effect. Key results The temperature was reduced
by SB (1.2 -2.5 g/kg) in a dose-dependent manner in mice for 2-4 hr. In
the brain, the effect was associated with SB elevation and
neurotransmitter (Glutamate and GABA) reduction. The mitochondria
exhibited a transient volume expansion and crista loss in the
hypothalamic neurons. ADP/ATP ratio was increased with accumulation of
intermediate metabolites in the glycolysis, TCA cycle and pentose
phosphate pathways. The mitochondrial protein, adenine nucleotide
transporter (ANT), was activated for proton transportation leading to a
transient potential collapse by proton leak. The SB activity was
attenuated by ANT inhibition from gene knockdown or pharmacological
blocker. The temperature drop was attenuated by i.p. injection of
norepinephrine. The HDAC inhibitors, such as SAHA and pyruvate, did not
exhibit the same effect. Conclusion and implications Super-dosed SB
generated an immediate and reversible toxic effect for inhibition of
body temperature through transient mitochondrial reprogramming in the
brain. The mechanism was activation of ANT proteins for the proton leak
in mitochondria.
Dose it reasonable to offer elective induction of labor to low-risk nulliparous women after 39 weeks？A retrospective analysis.
Authors: Zhang Qinjian , Chen Siwen , Xu Xia , Zhang Huale , Yan Jianying
Published: March 2022

Objective To investigate the effect of induced labor on maternal and
fetal pregnancy outcome. Methods This is a retrospective case-control
study.In this study, a total of 4386 pregnant women with singleton
low-risk who underwent regular prenatal examination and successful
vaginal delivery at or more than 41 weeks 0 days of gestation in Fujian
Maternal and Child Health Hospital from January 2014 to December 2018.
Review the clinical data,according to the mode of labor initiation, they
were divided into induced labor group (2007 cases) and spontaneous onset
of labor group (2361 cases). Further stratified analysis was carried out
according to age and parity. Results The total duration of labor in the
induced labor group was significantly longer than that in the
spontaneous onset of labor group[ (9.37±5.37)vs (8.82±5.13)
h,P＜0.001],associated with more postpartum blood loss[
(219.18±188.32)vs (199.95±124.69) mL,P=0.01], and the incidence of
severe postpartum hemorrhage(sPPH) was significantly
higher[0.8%(16/2007) vs 0.33% (8/2361),P =0.041];increase but no
significant difference in the incidence of postpartum hemorrhage(PPH)
[3.8 %(77/2007) vs 2.8% (66/2361),P =0.054]. After adjusting for
age, the operation of induced labor in nulliparous is more likely to
occur PPH[2.74 %(55/2007) vs 1.65
%(39/2361);OR=1.557;95%CI:1.039~2.332,P＜0.05].
Conclusion Selective induction of labor increases the postpartum blood
loss,especially primary parturients to increase the risk of postpartum
hemorrhage, may be related to the prolongation of the total stage of
labor.Low-risk nulliparous women should try to avoid induction without
medical indication
Single Bubble Motion Behavior in Viscoelastic Fluids: A Review
Authors: Li Shaobai , Xie Jun , Cao Baixu
Published: March 2022

The bubble motion behavior in viscoelastic fluid is very important the
in related gas-liquid processes. Thus, the emphasis of this review is to
discuss the three peculiar phenomena of bubbles rising in viscoelastic
fluids, i.e. the formation of the cusp, negative wake and velocity jump
discontinuity and to highlight the possible future directions of the
subject. The mechanism as well as influence factors on the three
peculiar phenomena is discussed in detail. The comparison of results has
shown that the change of bubble shape is mainly related to the
viscoelasticity of the fluid. However, the mechanism of two-dimensional
cusp, the tip-streaming, “blade-edge” tip, “fish-bone” tip and the
tail breaking into two different threads phenomena in some special
viscoelastic fluids is not very clear. For bubble velocity jump
discontinuity phenomenon, viscoelasticity is the most critical factor,
and the cusp of bubble, surface modification only played ancillary role.
Dependence of eigenvalues of Sturm--Liouville problems with eigenparameter-dependent boundary conditions and interface conditions
Authors: Zhang Hai-yan , Ao Jijun , Li Meng-lei
Published: March 2022

In this paper, regular Sturm-Liouville problems with
eigenparameter-dependent boundary conditions and interface conditions
are investigated. We obtain that the eigenvalues of the problems depend
not only continuously but also smoothly on the parameters of the
problem: the coefficients, the boundary conditions, the interface
conditions as well as the endpoints. Moreover, we find the differential
expressions for each parameters, respectively.
Herbal Research: Gaps With the High Impact on the Quality and Validity of Outcomes
Authors: Rezaei Arezou , Amirahmadi Atefe , Poozesh Vahid
Published: March 2022

Purpose Traditional medicine and herbal therapy, as a health-care
approach of traditional medicine, are receiving increased attention from
both the public and scientific society. The number of articles presented
on traditional medicine and its applications is increasing rapidly.
However, compared with extensive ongoing herbal research, achievements
are not remarkable. The objective of the present article is to highlight
some existing research gaps, which bridging the gaps will increase the
quality and validity of the results of herbal research. Methods Iranian
and non-Iranian articles on Allium sativum L. were reviewed for
compliance with standards and requirements for herbal research. Results
Botanical nomenclature, the processing and the extraction procedures,
and the history of traditional medicine were the most important gaps in
the herbal research. Conclusions Traditional and herbal medicines are
rich and promising sources for drug development. Researchers and authors
should consider that the familiarity with the history, characteristics,
and potentials of traditional medicine systems is an important factor,
accelerating the process of natural-based drug development. Moreover,
essential standards with a high impact on the validity and reliability
of the results of herbal research must not be ignored. Also, numerous
fields remain to be considered by scientists and researchers, including
the status of medicinal herbs, toxicological assessments, biological and
pharmacological mechanisms of disease, and research questions.
Soret Driven Convective Instability in Chemically Reactive Binary Nanofluids in the presence of Silver Nanoparticles
Authors: GAIKWAD SRAVAN , Surwase Dnyaneshwar
Published: March 2022

The onset of convective instability driven by thermodiffusion of
nanoparticles and solute in reactive binary nanofluids is investigated
theoretically using linear stability theory and addition factor
analysis. A horizontal layer of reactive binary nanofluid at constant
and different temperatures and concentrations is taken and the problem
is modeled by the system of highly nonlinear partial differential
equations. The stability equations are formulated and the expression for
Rayleigh number is derived for stationary and oscillatory convections.
The effect of nondimentional parameters namely chemical reaction
parameter, volume fraction of nanoparticles, Soret coefficients, Prandtl
number, heat of reaction parameter and addition factor on stability of
the system is shown graphically. The water/ammonia based silver binary
nanofluid is considered and the impact of nanoparticles on the stability
is studied by employing the Brinkman model for viscosity and Bruggeman
model for thermal conductivity. The enhancement of heat transport is
analysed by calculating ratio of heat transfer coefficients.
Prevention of self-harm through shared decision making among cardiac patients with implantable electronic devices
Authors: Chang Yu-Wei , Chen Ju-Yi
Published: March 2022

We present the case of a patient with anxiety who attempted suicide by
self-removal of her permanent pacemaker (PPM). Self-harm involving a
pacemaker is associated with significantly endangering patient
well-being and often with greatly increased health care costs. It is an
indication that the numbers of patients with a PPM who are clinically
depressed and anxious has been underestimated. Early detection of
depression, using a validated questionnaire, followed by ongoing care
and shared decision making (SDM), a focus on psychosocial stressors,
medication adherence, somatic complaints and attention to any adverse
drug reactions, are likely to improve clinical outcomes.
In-silico Analysis of Hypothetical Heat Tolerance Proteins in Maize
Authors: Ajmal Wajya , Majeed Aqsa , Khan Muhammad
Published: March 2022

Maize (Zea mays L.) holds significance importance in Pakistan in
addition to being the highest yielding cereal crop in the world. But its
yield has been severely affected due to the different environmental
constraints including heat stress. In order to meet the growing food
demand there is dire need to produce climate resilient varieties of
maize. For this purpose we need to exploit the biochemical and molecular
mechanisms involved in providing heat resistance to maize. In present
study four genes were selected which were reportedly involved in
response against heat stimulus, but were not structurally and
functionally characterized. Therefore in-silico approach was used in
order to investigate these hypothetical/candidate proteins. The
phylogenetic investigation was conducted to find the evolutionary
relationship. The 3D structures were elucidated in addition to the
secondary structure prediction. Conserved domains and their interactions
with other proteins were analyzed for the functional annotation. Our
results showed that the protein sequences of maize are showing constant
evolutionary change similar to their homologues. Predicted structures
and domains of HPs are involved in conferring heat tolerance to maize
crop. NP_001148903.1 is one of the HP; its interactions with other
proteins along with its predicted domains, suggests that it is involved
in stress response as most of its interacting partners are stress
responsive proteins. This theoretical overview of heat tolerance
proteins in maize will help researchers in understanding their predicted
structure and function which will aide them in designing the genetically
engineered varieties of heat resilient maize.
Dynamic Modeling and Analysis of Process Constraints for Improvement for Unipol® Polypropylene Fluidized Bed Reactor
Authors: Sbaaei Eslam , Fouad Mai Kamal , Ahmed Tamer
Published: March 2022

This work presents a dynamic model for Unipol® polypropylene fluidized
bed reactor (FBR) using Aspen Polymer Plus® with industrial data. The
model was developed by routing recently developed corresponding
steady-state model into Aspen Dynamics®. Industrial operational
scenarios of the plant FBR were utilized for model validation. The
previous steady-state analysis focused on reaching the optimum operating
scheme. However, neglecting the time factor may lead to inadequacy in
application. Upon, the current dynamic model was used to identify
process constraints obstructing process improvement. An automated HAZOP
study based on process control system protection layer analysis was
applied. This quantitative study illustrated that reduction of
superficial gas velocity by 10% to apply the scheme recommended by the
steady-state analysis may cause hazardous consequences and increase
waste production. Thus, revamping the existing FBR cooling system is
essential for applying the recommended scheme while ensuring safety and
cleaner production in the process.
Serial Lung Ultrasound for the Evaluation of Gravity-Induced Lung Injuries in Very Preterm Infants
Authors: Hoshino Yusuke , Arai Junichi , Hirono Koji , Yukitake Yoshiya , Kajikawa Daigo , Hinata Ayako , Miura Rena
Published: March 2022

Background: Gravity affects the distribution of lung injuries due to
gravity-induced nonhomogeneous ventilation leading to lung collapse and
subsequently non-uniform lung lesions. Moreover, lung injury gradients
gradually develop over time. However, changes in injury distribution
after birth have not been investigated in very preterm infants. Methods:
Preterm infants of less than 32 weeks’ gestational age were included in
this prospective observational study. Gravity-dependent lungs (DL) were
defined as dorsal lungs in a supine position or ventral lungs in a prone
position, and non-dependent lungs (NDL) were defined as ventral lungs in
a supine position or dorsal lungs in a prone position. Infants were
assessed using lung ultrasound (LUS), which was performed on days 7, 14,
21, and 28 post-birth. Each anterior and posterior lung was scanned and
received an LUS score of 0–3 points. LUS scores of the DL and NDL were
compared. Total LUS scores were provided using a 0–6 point scale, which
was obtained by adding the scores for each region of each lung. Results:
Eighty–eight patients were enrolled in this study. On days 7, 14, and
21, LUS scores between the DL and NDL groups were significantly
different (day 7, P = 0.01; day 14, P < 0.001; and day 21, P =
0.003). However, on day 28, there was no significant difference between
groups (P = 0.064). Conclusions: LUS can be used to detect
gravity-induced lung injury gradients in very preterm infants. Moreover,
LUS revealed a trend of gradient improvement over time.
Potential Drug Leads for SARS-CoV2 from Phytochemicals of Aerva lanata: An in silico approach
Authors: DR Sherin , TK Manojkumar
Published: March 2022

COVID-19 outbreak is the recently reported worldwide pandemic threat. As
part of our interventions with molecular simulation approaches, we
report the inhibitory effect of thirty compounds reported from the
sacred plant Aerva lanata and compare their activity with the one of the
present medication, hydroxy chloroquine, on the main protease (PDB:6YB7)
of SARS-CoV-2. Our studies pointed out the effectiveness of the plant
with twenty seven compounds having potential activity against the main
protease compared to the reference HCQ. The robustness of some of the
phytochemicals such as ervoside, which is only present in Aerva lanata
computed to have very high anticoronavirus activity. The results are
indicative of potential natural antivirus source, which subsidizes in
thwarting the invasion of coronavirus into the human body. Many
phytochemicals which are computed to be effective towards SARS-CoV-2 in
this study are used as drugs for various other diseases. Perhaps these
compounds could be attractive for the management of COVID-19, but
clinical trials must be performed in order to validate this observation.
Zinc Finger transcription factor ZAT Family Genes confer multi-tolerances in Gossypium hirsutum L.
Authors: Ye wuwei , Fan Yapeng , Zhang Yuexin , Rui Cun , Xu Nan , Zhang Hong , Wang Jing , Malik Waqar , Han Mingge , Zhao Lanjie , Lu Xuke , Chen Xiugui , Chen Chao
Published: March 2022

ZAT (ZINC FINGER OF ARABIDOPSIS THALIANA) proteins are composed of a
plant-specific transcription factor family, which play an important role
in plant growth, development and resistance to stress. To study the
potential function of ZAT family in cotton, the whole genome
identification, expression and structure analysis of ZAT gene family
were carried out. In this study, our analysis revealed the presence of
115, 56, 59, 115 ZAT genes in Gossypium hirsutum, Gossypium raimondii,
Gossypium arboreum and Gossypium barbadense, respectively. According to
the number of domains and phylogenetic characteristics, we divided ZAT
genes of four Gossypium species into 4 different classes, and further
divided them into 11 subfamilies. The results of collinearity analysis
showed that segmental duplication was the main method to amplify cotton
ZAT gene family. Analysis of cis-elements of promoter indicated that
most GhZATs genes contained cis-elements related to plant hormones and
abiotic stress. According to heatmap analysis, the expression patterns
of GhZATs genes under different stress treatments indicated that GhZATs
genes were significantly involved in the response to cold, heat, salt,
and PEG stress, possibly through different mechanisms. Among the highly
expressed genes, we cloned an Gossypium hirsutum gene GhZAT67. Through
virus-induced gene silencing (VIGS), we found that its expression
decreased significantly after being silenced. After alkaline treatment,
the wilting degree of silencing plants (VIGS) was even greater than WT,
which proved that GhZAT12 gene was involved in the response to alkaline
stress.
Differences in D-dimer Blood Concentration in Atrial Fibrillation Patients with Left Atrial Thrombus or Severe Left Atrial Spontaneous Echo Contrast
Authors: lin changjian , Bao Yangyang , Hua Wei , Zhang Ning , Jin Qi , Xie Yun , Wei Yue , Luo Qingzhi , Liu Zhuhui , Ling Tianyou , Pan Wenqi , Xie Yucai , Wu Liqun
Published: March 2022

Background:  Severe left atrial spontaneous echo contrast (SLASEC) is
considered the prior stage to thrombosis. Studies have suggested an
effect of D-dimer blood concentration on exclusion of left atrial
thrombus (LAT), but it remains unclear whether D-dimer concentrations
differ between atrial fibrillation (AF) patients with SLASEC or LAT.
Methods: Nonvalvular AF patients scheduled to undergo catheter ablation
or cardioversion between January 2017 and July 2020 were screened for
this prospective study. All patients underwent transesophageal
echocardiography (TEE) to detect SLASEC or LAT.  Results: 35 patients
with SLASEC and 22 patients with LAT were detected. D-dimer
concentration and CHA 2 DS 2 -VASc score were significantly lower in the
SLASEC group compared with the LAT group (D-dimer: 0.26±0.13 vs.
0.87±0.9 mg/L, P<0.001; CHA 2 DS 2 -VASc score: 2.3±0.9 vs.
3.1±1.5, P =0.02). The cut-off value for D-dimer concentration (0.285
mg/L) had sensitivity of 77.3% and specificity of 80.0% for prediction
of LAT. D-dimer concentration showed a decreasing trend with a
significant difference  after complete thrombus resolution in the LAT
group by anticoagulation treatment. No ischemic stroke, or systemic
thromboembolism events occurred in the SLASEC group during the 6-month
follow-up. Conclusions: This study demonstrated a significantly lower
D-dimer concentration and CHA2DS2 -VASc score in AF patients with SLASEC
than in those with LAT. The D-dimer cut-off value (0.285 mg/L) can be
used as an effective reference index to distinguish the pre-thrombotic
state of LAT from LAT. D-dimer blood concentration may be a predictor of
LAT thrombolysis.
Connected domination game: Predomination, Staller-start game, and lexicographic products
Authors: Irsic Vesna
Published: March 2022

The connected domination game was introduced in 2019 by Borowiecki, Fiedorowicz and Sidorowicz as another variation of the domination game. We answer a problem from their paper regarding the relation between the number of moves in a game where Dominator/Staller starts the game. Additionally, we study the relation to the diameter and present graphs with small game connected domination number. We also determine the value on the lexicographic products, and consider the effect of predomination of a vertex.
Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy
Authors: Kozik Bojana , Krajnovic Milena , Kokanov Nikola , Jovanovic-Cupic Snezana , Bozovic Ana , Todorovic Lidija , Mandusic Vesna
Published: March 2022

Current management of locally advanced rectal carcinoma (LARC) involves preoperative chemoradiotherapy (preCRT) before surgery. Despite improved local control rate, the response to preCRT of individual patients is variable and may reflect heterogeneous biological properties among tumors of the same clinical stage. Identifying novel molecular parameters with predictive and/or prognostic value is of great clinical importance for a personalized therapeutic approach. In this study, KRAS mutation status was analyzed by direct sequencing, while methylation-specific polymerase chain reaction (MSP) was used to examine p16INK4a and p14ARF gene methylation status in pretreatment tumor biopsies of 60 patients with LARC. The examined molecular changes of KRAS, p16INK4a and p14ARF genes were mutually independent (p16INK4a/KRAS, P=0.272; p14ARF/KRAS, P=0.923; p16INK4a/p14ARF, P=0.715). However, the simultaneous presence of p14ARF methylation and KRAS mutation was associated with a more frequent appearance of local recurrences and distant metastasis (P=0.027). Moreover, patients with the simultaneous presence of p16INK4a and p14ARF methylation and KRAS mutation had significantly shorter overall survival (P=0.011). The obtained results strongly suggest that combined analyses of examined genetic and epigenetic molecular alterations could contribute to the identification of LARC patient subgroups with more aggressive tumor behavior and worse disease outcome.
The social movement for truth and justice - pragmatic alliance-building with political parties in Bosnia and Herzegovina
Authors: Repovac-Niksic Valida , Hasanovic Jasmin , Adilovic Emina , Kapidzic Damir
Published: March 2022

Protests among citizens of Bosnia and Herzegovina are becoming more frequent.
Most often, their aim is to decry the dysfunctionality and opacity of the
government, which are the result of the ethno-political structure created by
the Dayton Agreement, but also a trend towards democratic regression and
autocracy. A number of authors have tackled the ?JMBG? protests of 2013 and
the Plenums that emerged from the February 2014 protests, from their
particular disciplines. The focus of this paper is the social movement
?Justice for Dzenan,? organized by the Memic family upon the tragic death of
Dzenan Memic in Sarajevo in February 2016. An in-depth study was conducted
with key actors of the movement, as well as those who follow or in some way
support the protests. Particular emphasis in the research was paid to the
pragmatic symbiosis of the social movement and one political party. We argue
that it is possible to identify a pragmatic symbiosis as a novel form
(democratic innovation) of socio-political cooperation that can impede
rising autocratization. Through the quest for accountability, social
movements are introducing new strategic practices of mobilization and a
novel type of alliance-building with external factors (new political parties
as well as other social movements). The goal of the paper is to explore how
the social movement ?Justice for Dzenan? interacts with political parties
and approach the political sphere in BiH. Also, the idea is to examine the
possibilities and functionality of this kind of cooperation with the
framework of contentious politics.
Cicero and hobbes on the person of the state
Authors: Simendic Marko
Published: March 2022

The importance of Thomas Hobbes?s account of personation and representation can hardly be overstated. And his intellectual debt to one of his classical foes, Marcus Tullius Cicero, can hardly be ignored. This paper compares Hobbes?s ideas on personhood of the state with Cicero?s notion of persona civitatis, and attempts to describe how Hobbes reshaped Cicero?s guidelines for (re)presenting legitimate authority into a prop for defending any effective authority. Hobbes absorbs Cicero?s influential argument and builds on the idea of civic representation as guardianship done by role-playing, while tearing down Cicero?s account?s ethical foundations. In contrast to Cicero?s magistrate, the social role of Hobbes?s sovereign is not scripted by ethical constrains: its purpose is not to restrict license, but to present it.
Clostridial enterocolitis in an emu (Dromaius novaehollandiae)
Authors:   Texas A&M University, College Station, TX, USA, Hoskins Emily , Stranahan Lauren W. ,   Texas A&M University, College Station, TX, USA, Blue-McLendon Alice ,   Texas A&M University, College Station, TX, USA, Rech Raquel ,   Texas A&M University, College Station, TX, USA
Published: March 2022

Clinical History: A 25-year-old female emu (Dromaius novaehollandiae) presented with a 1-week history of lethargy, hyporexia, and recumbency. The bird had lived its entire life at the Winnie Carter Wildlife Center in Texas and had an unremarkable medical history, apart from bilateral congenital blindness. Necropsy Findings: Within the coelomic cavity, the serosal surface of the intestines was coated with a moderate amount of tan to green, mucoid, opaque, foul-smelling fluid (fibrinoheterophilic coelomitis) (Fig. 1). The large intestine was diffusely dilated and filled with dark red fluid and strands of yellow, friable material (fibrin). The mucosa of the small intestine, and most severely the colon, was diffusely roughened, thickened, dull, and covered by a thick yellow to green, opaque, friable diphtheritic membrane (Fig. 2). The distal colon was diffusely, markedly distended and focally contained a 50x7x5 cm, semi-firm accumulation of feces coated by a 4-5 mm diameter layer of tan, friable material (fibrin) located 21 cm from the opening of the cloaca. Gross evaluation of the eyes revealed bilateral aphakia.
The Best Data Integration Method by Using SAW Technique in Ministry of Science, Research and Technology (MSRT)
Authors: Shokri Mahsa , Pourebrahimi Ali Reza
Published: March 2022

Many computer systems are usually used by organizations. The data within different systems should be integrated in order to analyze and provide a report. Methodology: The method of saving data and files often focused in the past, the data structure and flow received little attention, therefore, the large volume of data and data transfer management carry into account as a big challenge. Results: Since information systems are growing in the organizations, the number and entanglement of interfaces will increase. If the data integration strategy is disregarded, the organization will meet numerous problems. Conclusion: There are 4 different data integration methods which have their special usage. This article concentrates on the process of data integration and aims to understand the meaning and methods of data integration, to identify variables and effective factors on data integration, to rank the variables of data integration and to provide the best method of data integration by SAW Technique for the Ministry of Science, Research and Technology.
Evaluation of perspectives related to FMIS implementation from Urmia Jihad farming organization in six factors
Authors: Esakan Mehdi Mohammadzadeh , Rezaei Hossain
Published: March 2022

In this research, we evaluate the different perspectives of Urmia jihad keshavarzi organizations experts from different factors as follows economic, social, education, policy and technical. And with pay attention to expert's condition in each factor of age, gender, the field of their study and participating in farming management information systems educational courses in jihad organization. Methodology: Present research is done in Correlation Descriptive method and research tool is questionnaire. Results: In the case of questionnaire validity we helped from administrative professionals and professors and Cronbach alpha test is used to evaluate questionnaire evaluate stability. Conclusion: In this case, 25 questionnaires distributed among jihad keshavarzi experts institute that the resulted value of Cronbach alpha showed suitable stability of research tool. 75 workers of institute individuals managerial in duration years between "2014-15" was chosen to survey. The data with SPSS application in windows is analysed
Music and its role on the identity of female's body (Case study: The female students of Imam Reza)
Authors: Divkolaii Masoumeh Seifi , Fayaz Ebrahim , Khojasteh Hasan
Published: March 2022

The existing research aims to survey the impact of music on the female's body. Methodology: The research population includes 448 female students of Imam Reza (p.b.u.h). Results: the analysis of data shows the music impact on each dimension of body identity (emotional, behavioral, cognitive). Conclusion: Due to existing hypotheses assessment and data analysis we come to this conclusion that listening to music can change women's body identity accordingly.
An Empirical Study: Impact of Integrated Marketing Communications (IMC) On Brand loyalty
Authors: Aghajani Ahmad
Published: March 2022

This current study has done to investigate the relationship between integrated marketing communications (IMC) and loyalty to brand in view point of customers of detergent industries companies In Karaj City. Methodology: The statistical population in this study is consists of customers in detergent companies In Karaj City which 384 people is as the sample size of customers, by using the Cochran formula with the method of available and simple random sampling were selected.  For collecting data by the method of Questionnaires were used, questionnaires selected in this study were standard. Results: Data with statistical programs in both descriptive and inferential statistics were analyzed. The reliability of questionnaires with Cronbach's alpha coefficient was calculated and these coefficients for questionnaires integrated marketing communications and brand loyalty respectively was equal to 0.788, 0.754 and 0.717. All Hypotheses at the level of 95% confidence were confirmed. Conclusion: The results of the Minor hypotheses showed that sale promotion on brand loyalty in the first rank, advertising on brand loyalty in the second rank, public relations on brand loyalty in the third rank, direct marketing on brand loyalty in fourth rank and the last rank have located.
Impact of a Pharmacist-Led Warfarin to Direct Oral Anticoagulant Conversion Initiative during the COVID-19 Pandemic
Authors: Mews Kelsey , Umbreit Audrey , Holm Emily , Davis Kelsie , Kelly Ellen , Reinhardt Carson , Young Allison , Flynn Joseph
Published: March 2022

Purpose: To assess the impact of a pharmacist-led warfarin to DOAC conversion initiative during the COVID-19 pandemic.
Methods: Patients who were prescribed warfarin and followed with the anticoagulation clinic for INR monitoring were assessed by outpatient clinical pharmacists as potential candidates for transition to DOACs from March-August 2020.
Results: 530 patients were assessed for transition to DOACs, of which 373 (70.4%) were deemed by clinical pharmacists to be candidates for DOACs.  Of the patients who were candidates for DOACs, 66 (17.7%) were transitioned from warfarin to a DOAC.  Of the patients who transitioned to a DOAC, 59 (89.4%) remained on a DOAC after one year.
Conclusion: Outpatient clinical pharmacists are an effective resource to help identify patients who are candidates for DOACs and assist with transition from warfarin. Further, high persistence rates with DOAC therapy after one year demonstrate the positive impact of the clinical pharmacist on medication adherence.
Kierunki niepożądanych działań leków przeciwdepresyjnych w obrębie skóry i jej przydatków
Authors: Piotrowska Anna , Nastałek Magdalena
Published: March 2022

The side effects of many drug classes cover a wide range of skin reactions. One of the most commonly diagnosed diseases nowadays is depression also, antidepressants are widely used in other indications. Therefore, paying attention to the possible undesirable effects of this group of drugs is worth. In the practice of an occupational medicine physician, unfavorable manifestations of the drugs used in the area of the skin should be skillfully differentiated from occupational skin diseases. The aim of this article was to review the types of skin, hair and nail complications in patients treated with antidepressants. For this purpose, online databases were reviewed and case reports, research and review reports were analyzed. The characteristics of severe skin complications generated with antidepressants were presented, as well as case studies of their occurrence after starting the treatment. Complications of a lower severity were also reviewed. Examples of actions in the area of hair and nails were indicated. In the literature on the subject, there are
Natural Convection from Discrete Heat Sources Placed in Wavy Enclosure
Authors: Mustafa Ahmad W. , Abood Mustafa Z.
Published: March 2022

The effect of sinusoidal corrugated upper surface for enclosure on the heat transfer by natural convection from two heat sources placed on the bottom surface of the enclosure has been studied. The two heat sources constant and high temperature, length of each heat source (10%) from the total length of bottom surface, the distances that do not contain heat source on the bottom surface thermally insulated, temperature of verticals walls and upper surface low and constant. corrugating upper surface was change the dimensional corrugation amplitude between (0.1-0.3), for number of corrugations (3), the dimensional distances between the two heat sources were change between (0.2-0.8), the Rayleigh numbers ranged between (103 ≤ Ra ≤ 105), the fluid inside the enclosure was air Prandtl number for it (0.7). were analyzed flow and temperature fields inside the enclosure numerically by solving Navier Stokes and Energy Equations, have been used Cartesian velocity components and pressure on a collocated grid are used as dependent variables in the momentum equations which discretized by finite volume method, body fitted coordinates are used to represent the geometry shape of the problem accurately, were grid generated technique based on elliptic partial differential equations, SIMPLE algorithm is used to adjust the velocity field to satisfy the conservation of mass. The results showed the increase in the magnitude of dimensional distance between two heat sources lead to increased average Nusselt number for all values of Rayleigh numbers (103 ≤ Ra ≤ 105), as are the highest value of the average Nusselt number at dimensional distance (0.8)and less value at the dimensional distance (0.2), the dimensional distance (0.6) is a special case when the Rayleigh number equal (105) as at least average Nusselt number from the remaining values of the two dimensional distances (0.2) and (0.4), as the average Nusselt number increases with increasing dimensional corrugation amplitude for the number of corrugations (N=3) for dimensional distance (0.8), as well as comparing numerical results showed good agreement with published results.
On-surface Synthesis: What Happens Behind the Scenes?
Authors: Stolz Samuel , Di Giovannantonio Marco , Gröning Oliver , Widmer Roland
Published: March 2022

On-surface synthesis has become a powerful approach to produce low-dimensional carbon-based nanostructures with atomistic precision. A large variety of analytical tools and methods are available to provide efficient monitoring of on-surface reactions, among which, scanning probe microscopy (SPM) has proven to be particularly efficient to characterize reaction intermediates and products down to the atomic scale. Nevertheless, due to limited temporal resolution, difficulties to explore the full temperature range, and lack of identifying the chemical environment of all elements involved in on-surface processes, SPM is ideally complemented with temperature programmed X-ray photoelectron spectroscopy (TP-XPS). In this short review, we aim to unveil some of the capabilities of synchrotron based TP-XPS reporting on our own research on Ullmann-type on-surface coupling reactions.
Theoretical Inspection of TM-P4C Single-Atom Electrocatalyst: Ultra-High Performance for bifunctional Oxygen Reduction and Evolution Reactions
Authors: Chaohong Guan , Ouyang Runxin , Zhu Hong , Xie Yangyang
Published: March 2022

Developing the cost-effective or even bifunctional electrocatalysts for both oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) with industrially relevant activity is highly desired for metal-air batteries at the current stage. Herein, in this work, the catalytic performances of the single transition metal (TM) atom embeds graphene sheet with the tetra-coordinates Phosphorus (TMP4) for ORR and OER were investigated based on the density functional theory method. The results demonstrate that the most promising ORR and OER catalytic activity can achieved on the CoP4 with the smallest potential gap ∆E and the lowest overpotentials of 0.37 and 0.32 eV among all TMP4 systems, respectively, and the catalytic activity is even better than that of the traditional Pt and IrO2 catalysts. Furthermore, the AIMD calculation was conducted to confirm the thermodynamics stability of CoP4. This work screens out promising candidates for novel graphene-based bifunctional ORR and OER catalysts and provides the theoretical guidance for the development of single-atom catalysts.
Powerful avidity with a limited valency for virus-attachment blockers on DC SIGN: Combining chelation and statistical rebinding with structural plasticity of the receptor
Authors: Porkolab Vanessa , Lepšík Martin , Ordanini Stefania , St John Alexander , Le Roy Aline , Thépaut Michel , Paci Emanuele , Ebel Christine , Bernardi Anna , FIESCHI Franck
Published: March 2022

The C-type lectin receptors DC-SIGN and L-SIGN have been highlighted as co receptors for the spike protein of the SARS-CoV-2 virus. A multivalent glycomimetic ligand, Polyman26, has been described as able to inhibit DC-SIGN-dependent trans-infection of SARS-CoV-2. The molecular details underlying avidity generation in such system remain poorly characterized. In an effort to dissect the contribution of the known multivalent effects of Polyman26 - chelating, clustering and statistical rebinding – we studied a series of dendrimer constructs with a rod core rationally designed to engage simultaneously two binding sites of the tetrameric dendritic cell lectin receptor DC-SIGN. Different binding properties of these compounds have been studied with a range of biophysical techniques. Using molecular modelling we addressed, for the first time, the impact of the carbohydrate recognition domains’ flexibility of the DC-SIGN tetramer on the compounds’ avidity. We were able to gain deeper insight into the role of different binding modes, which in combination produce a construct with a nM affinity despite a limited valency. This multi-faceted experimental-theoretical approach provide detailed understanding of multivalent ligand/multimericprotein interactions which can lead to future predictions. This work opens the way to the development of new virus attachment blockers adapted to different C-type lectin receptors of viruses.
Post-synthetic modification of a porous hydrocarbon cage to give a discrete Co24 organometallic complex
Authors: Thomas Chriso , Liang Weibin , Preston Dan , Doonan Christian , White Nicholas
Published: March 2022

A new alkyne-based hydrocarbon cage was synthesized in high overall yield using alkyne–alkyne coupling in the cage forming step. The cage is porous and displays a moderately high BET surface area (546 m2 g–1). The cage loses crystallinity on activation and thus is porous in its amorphous form, while very similar cages have been either non-porous, or retained crystallinity on activation. Reaction of the cage with Co2(CO)8 results in exhaustive metalation of its 12 alkyne groups to give the Co24(CO)72 adduct of the cage in good yield.
Understanding reversibility of lithium–oxygen batteries based on LiOH formation and decomposition
Authors: Zhang Xiahui , Dong Panpan , Noh Seunghyo , Zhang Xianghui , Cha Younghwan , Ha Su , Jang Ji-Hoon , Song Min-Kyu
Published: March 2022

Lithium–oxygen batteries based on four-electron conversion to LiOH have demonstrated great potential for next-generation high-energy batteries. However, the understanding of LiOH-based cathode chemistry remains incomplete. Here, we use systematic characterization techniques to study LiOH chemistry, revealing that “high-performance” LiOH chemistry is achieved at the expense of electrolyte degradation and is irreversible in commonly used liquid organic electrolytes. LiOH forms via four-electron reduction of O2 during discharge, whereas LiOH decomposes via one-electron oxidation during charge. This one-electron oxidation of LiOH generates surface-reactive hydroxyl species that aggressively degrade organic electrolytes. The reaction mechanisms are further supported by computational studies. Our findings suggest that the key to enable reversible LiOH chemistry is bypassing surface-reactive hydroxyl formation or using stable solid-state electrolytes, which can be explored by future research. Our findings also shed lights on the reversibility of four-electron cathode chemistries in other metal–air batteries.
Site Specific NMR Characterization of Abeta-40 Oligomers Cross Seeded by Abeta-42 Oligomers
Authors: Chang Han-Wen , Ma Ho-I , Wu Yi-Shan , Lee Ming-Che , Yuan Eric Chung-Yueh , Huang Shing-Jong , Cheng Yu-Sheng , Wu Meng-Hsin , Tu Ling-Hsien , Chan Jerry Chun Chung
Published: March 2022

Extracellular accumulation of β amyloid peptides of 40 (Aβ40) and 42 residues (Aβ42) has been considered as one of the hallmarks in the pathology of Alzheimer’s disease. In this work, we are able to prepare oligomeric aggregates of Aβ with uniform size and high structural homogeneity. Our experimental design is to incubate Aβ peptides in reverse micelles (RMs) so that the peptides could aggregate only through a single nucleation process and the size of the oligomers is confined by the physical dimension of the reverse micelles. The hence obtained Aβ oligomers (AβOs) are 23 nm in diameter and they belong to the category of high molecular-weight (MW) oligomers. The solid-state NMR data revealed that Aβ40Os adopt the structural motif of β-loop-β but the chemical shifts manifested that they are structurally different from low-MW AβOs and mature fibrils. From the thioflavin-T results, we found that high-MW Aβ42Os can seed the fibrillization of Aβ40 monomers. Our protocol allows performing cross-seeding experiments among oligomeric species. By comparing the chemical shifts of Aβ40Os cross seeded by Aβ42Os and those of Aβ40Os prepared in the absence of Aβ42Os, we observed that the structures of E11, K16, and E22 were altered, whereas the backbone conformation of the β-sheet region near the C-terminus is structurally invariant. The use of reverse micelles allows hitherto the most detailed characterization of the structural variability of Aβ40Os.