bluuebunny/crossref_metadata_2025 huggingface dataset:
Status of Stock Market Concentration and Turnover at Nepal Stock Exchange
Authors: Rajesh Gurung
Published: August 2023

This paper examines the status of stock market concentration and turnover in Nepal Stock Exchange (NEPSE) during the period from Mid-July 2003-04 to Mid-July 2019-20. Despite the NEPSE’s high concentration and low degree of liquidity, the research reveals that stock market concentration and turnover are gradually improving, with the banking sector playing a key role in market concentration. It also finds a negative association between market concentration and stock turnover, meaning that a decrease in stock concentration is accompanied by an increase in turnover (or liquidity) across the study period. This has important policy implications, particularly in terms of reducing the market concentration and improving liquidity. Encouraging family-owned business to go public and attracting international capital flows so as to reduce investment risk and increase confidence of market participants in the capital market of Nepal.
Explaining Entrepreneurial Success of SMEs Entrepreneurs: The Role of Entrepreneurial Characteristics
Authors: Prakash Kumar Gautam  , Ram Bahadur Khadka
Published: August 2023

Small and medium sized enterprises have significant role in sustainable economic growth and country. This study aims to investigate the entrepreneurial characteristics predicting entrepreneurial success of small and medium sized enterprises. Following analytical research design, this study collected data using structured questionnaire from 263 entrepreneur managers. Result revealed that entrepreneurial motivation, entrepreneurial self-efficacy, and risk-taking propensity have significant role in predicting entrepreneurial success of SMEs but refuted for entrepreneurial innovativeness. Moderating role of gender was examined in the study. The result advocates that the study contributes to the entrepreneurial competency theory and contributes for policy makers for entrepreneurial growth for sustainable development goals.
Tax Payers Awareness in Nepal Regarding with Value Added Tax and Income Tax
Authors: Jitendra Prasad Upadhaya  , Paras Mani Acharya
Published: August 2023

This study analyzes the moral behavior of Nepalese taxpayers. Additionally, the study seeks to address the underlying reasons for non-compliance. Data were collected by 400 participant questioners and analyzed using thematic analysis. The result suggests that these taxpayers do not have sufficient technical knowledge and perceive the VAT system as complex. Tax knowledge and tax complexity are seen as contributing factors to taxpayer non-compliant behavior. Data is collected using a well-structured questionnaire. For analysis and interpretation, the researcher used the following statistical tools from her SPSS: Based on their analysis and interpretation, the researchers present important findings that the majority of consumers pay tax but are less aware of VAT. Consumers avoid paying tax in Nepal as VAT tends to be high.
The effects of personality types and coping styles on coronavirus anxiety levels of the healthcare workers
Authors: TOPAK Osman Zülkif
Published: August 2023

Purpose: Healthcare workers are exposed to long and stressful work shifts in pandemics. It was aimed to evaluate the coronavirus related anxiety levels of the healthcare workers, and to evaluate the relationship between their personality types and coping strategies.

Materials and Methods: Study included 213 medical healthcare workers who were randomly selected and agreed to participate in the study on a voluntary basis. Sociodemographic data form, Coronavirus anxiety scale, Type A Behavior Test, and Coping styles scale was applied to the all participants.

Results: The total coronavirus anxiety scores of the participants with type A personality traits were found to be significantly higher than with type B personality traits (p=0.006). The mean scores of helpless approach and seeking social support of were found to be significantly higher in participants with Type A personality (p=0.002, p=0.007, respectively). Self-confident and optimistic approach were found to be higher in participants with Type B personality (p=0.041, p=0.023, respectively). Participants with helpless approach had higher anxiety scores (p=0.033). A negative correlation was found between coronavirus anxiety and self-confident approach (p=0.002, r=-0.212) and optimistic approach (p=0.002, r=- 0.209), and positive correlation with helpless approach (p=0.044, r=0.138).

Conclusion: The results of this study showed that those who approached self confident and optimistic can cope with stress better. Individuals with Type A personality are at greater risk for anxiety in the pandemic. Monitoring and ensuring the mental health of healthcare workers is crucial to global health in other possible pandemics.
Training on Preparation of Islamic Integrated HOTS-Based Questions and Their Application in Online Learning in Elementary Schools
Authors: Susilawati Samsul , Yaqin Muhamad Zubad Nurul , Wahidmurni Wahidmurni , Ulfa Fazat Arifatul , Krismoneta Krismoneta
Published: August 2023

. The training for preparing Higher Order Thinking Skills (HOTS) Questions was motivated by the problems faced by Elementary Schools teachers in Malang Regency, in making learning evaluation questions given in assessing student learning outcomes so far, they are still at the Lower Order Thinking Skills level (LOTS). This is due to the lack of knowledge and understanding of teachers about the concept of HOTS and the lack of ability and skills of teachers in preparing HOTS-based questions. The training for preparing Higher Order Thinking Skills (HOTS) Questions was held at MI Hayatul Islam, Malang Regency, the training participants were Elementary Schools teachers in Malang Regency. This community service activity for the Masters of Education Master’s Program in Elementary Schools Postgraduate Islamic University Maulana Malik Ibrahim Malang Islamic University is carried out by providing training and assistance in preparing questions based on guidelines for writing HOTS questions, especially for grade IV and V teachers. Through lecture, question and answer, discussion, and In practice, this training turned out to be able to open up insight into the knowledge, understanding, and skills of teachers on how to compose questions and improve teachers' abilities and skills in making questions at the level of higher-order thinking skills so that they can be used to measure the development of students' thinking and reasoning abilities properly in accordance with the final results The expected learning is that students can think critically and creatively so that they can apply their knowledge and skills to identify and solve problems encountered in everyday life.
Aquinas’ conceptual synthesis: an attempt at a new clarification. Stump, E., & White, T. J. (Eds.). (2022). The New Cambridge Companion to Aquinas. Cambridge: Cambridge UP.
Authors: Shymanovych Andrii
Published: August 2023

Review of Stump, E., & White, T. J. (Eds.). (2022). The New Cambridge Companion to Aquinas. Cambridge: Cambridge UP.
A rare case of multifocal chordoma involving the lower clivus and multiple spine levels: illustrative case
Authors: Alsavaf Mohammad Bilal , Salem Eman H , Jawad Basit A , Mongkolkul Kittichai , Carrau Ricardo L , Prevedello Daniel M
Published: August 2023

BACKGROUND

Chordomas are rare bone tumors originating from notochord remnants with a predilection for the median axis of the body, primarily in the sacrococcygeal spine, skull base, and cervical spine. This paper presents the first reported case of simultaneous multilevel chordomas with various enhancements.

OBSERVATIONS

A 40-year-old woman presented with right-sided otalgia, headache, nasal obstruction, and facial pressure. The patient’s head and spinal magnetic resonance imaging (MRI) demonstrated a midline lesion in the clivus, C2, and T1–5 spinal levels. All lesions were T1 isointense and T2 hyperintense, consistent with chordoma. Interestingly, the clivus lesion was enhancing, whereas the C2 lesion was only slightly enhancing, and the rest of the lesions showed no enhancement. The patient underwent endoscopic endonasal transclival approach surgery for the clival lesion, followed by radiation to the surgical bed and the C2 lesion. The remaining lesions were monitored. Follow-up imaging showed stable disease in the C2 lesion and other lower lesions. The patient’s severe pain in the posterior cervical spine was managed with cervical fusion, pain management, and physical therapy.

LESSONS

This case underscores the importance of comprehensive spinal MRI in patients with chordomas, as multiple concurrent primaries may be present. The article summarizes the fundamental distinctions between ecchordosis physaliphora and chordoma and casts doubt on the capacity to always differentiate them.
EFEITO BATOM, SUSTENTABILIDADE E OS IMPACTOS DA PANDEMIA COVID 19 NO CONSUMO NO BRASIL
Authors: Francisca Noeme Moreira de Araújo  , Marcelo Victor Alves Bila Queiroz  , Walid Abbas El-Aouar  , César Ricardo Maia de Vasconcelos
Published: August 2023

A pandemia provocada pelo Covid-19 já é considerada uma das maiores da história e afetou diretamente a vida das pessoas, inclusive o consumo, exigindo das organizações rápidas adaptações. A partir desse contexto, este estudo tem como objetivo geral identificar se as pessoas modificaram seus hábitos de consumo no que se refere a produtos de higiene e cuidados pessoal, cosméticos e perfumaria desde o início da pandemia. O processo de coleta de dados aconteceu de maneira online e obteve a participação de 137 pessoas. A pesquisa é de caráter descritiva e quantitativa. Os resultados apontam que as pessoas modificaram o estilo de consumo dos produtos estudados e que o batom deixou de ser o item mais consumido, dando lugar a outros produtos cosméticos e de cuidados com a pele, contrariando os resultados do efeito batom. Além disso, identificou que as questões relacionadas a qualidade, preço e crueltly free, são critérios a serem analisados na escolha desses produtos, embora continuem consumindo produtos de marcas que não são crueltly free.
Manajemen Pemanenan Kelapa Sawit (Elaeis guineensis Jacq) Di Pt. Asn, Perkebunan Batee Puteh, Afdeling I
Authors: Qhamar Samsul , Afrillah Muhammad
Published: August 2023

Penelitian ini bertujuan untuk mengetahui manajemen pemanena kelapa sawit secara teknis, pengelolaan, dan menganalisis produksi yang dihasilkan di perkebunan kelapa sawi PT. Agro Sinergi Nusantara, Kebun Batee Puteh, AfdellingI Aceh Barat Pada Agustus-November 2022. Pengumpulan data dalam penelitian ini dilakukan dengan mengumpulkan data primer dan data sekunder. pengumpulan data prime diperoleh melalui pengamatan langsung di lapangan, diskusi maupun wawancara dengan karyawan, mandor dan asisten afdeling.I. Data sekunder diperoleh dari data yang ada di kebun meliputi lokasi geografis kebun, keadaan iklim, luas areal dan tata guna lahan, produksi dan produktivitas, struktur organisasi perusahaan, dan peraturan atau norma baku perusahaan. Hasil penelitian menunjukkan Manajemen pemanenan kelapa sawit di Perkebunan Batee Puteh Afdeling I sudah berjalan cukup baik, yang mana dari kriteria sangat baik pada beberapa parameter pengamatan seperti rotasi panen, mutu dan kebersihan ancakak panen. Rotasi panen yang diterapkan dengan sitem acak tetap/acak giring Rotasi panen tertinggi terjadi pada bulan September yaitu sebanyak 28 Rotasi sedangkan rotasi terendah terdapat pada bulan oktober sebanyak 24 dan pada bulan Agustus sebanyak 27 kalai rotasi panen . Kriteria matang panen yang diberlakukan pada Prekebunan Batee puteh adalah 3 brondolan per-tandan di piringan sebelum di potong.

Kata kunci: Manajemen, Panen, Kelapa Sawit.
Wieloosobowe pomocnicze organy w zarządzaniu Kościołem partykularnym
Authors: Wroceński Józef
Published: August 2023

The author in his paper analyzed the provisions specifying the legal status of auxiliary collegial administrative organs in a particular Church. The Second Vatican Council determined the collegiality in the universal Church, admittedly, but it can be said the same in the particular Church. New consultative organs were created, similar to the colleges, which are not the entity of the power of governance, but with their advice and proposais support the diocesan bishop in managing the diocese. The following should be distinguished: the presbyteral council, the college of consultors, the finance council, the group of pastor consultors, and also the pastoral council, the episcopal council and the mediation council. Their role, especially in these days, is very important, because they contribute to the achievement by the diocesan bishop much more understanding in making the binding decisions.
Ś.p. Ks. dr Robert Mikołaj Guz (1961-2015)
Authors: Kaczor Adam
Published: August 2023

Ks. Robert Mikołaj Guz, s. Cecylii i Henryka, urodził się 6 grudnia 1961 r. w Kocku (diecezja siedlecka). Do szkoły podstawowej uczęszczał w Zamościu i Puławach, co było związane ze zmianami zamieszkania powodowanymi pracą rodziców. Po otrzymaniu świadectwa maturalnego w Liceum Ogólnokształcącym im. Unii Lubelskiej w Lublinie w czerwcu 1980 r. złożył podanie do Wyższego Seminarium Duchownego w Lublinie. W latach 1980-1985 odbył studia filozoficzno-teologiczne w Katolickim Uniwersytecie Lubelskim. Dnia 4 kwietnia 1985 r. przyjął święcenia diakonatu z rąk ks. bp. Jana Śrutwy, ówczesnego Biskupa Pomocniczego Diecezji Lubelskiej. Dnia 21 grudnia tegoż roku przyjął święcenia kapłańskie z rąk ks. bp. Bolesława Pylaka, Biskupa Diecezji Lubelskiej.
Sprawozdanie z Międzynarodowej Konferencji Naukowej Kanonistów Przynależność do Kościoła a uczestnictwo wiernych w życiu publicznym. Kielce, 5-7 września 2013 roku
Authors: Pełka Michał
Published: August 2023

„Przynależność do Kościoła a uczestnictwo wiernych w życiu publicznym” – taki temat przyświecał uczestnikom Konferencji Naukowej Kanonistów zorganizowanej pod patronatem ks. bpa prof. dra hab. Kazimierza Ryczana w dniach 5-7 września 2013 r. przez: Stowarzyszenie Kanonistów Polskich, Kurię Diecezjalną w Kielcach, Wyższe Seminarium Duchowne w Kielcach, Świętokrzyski Instytut Teologiczny w Kielcach, Katedrę Kościelnego Prawa Publicznego i Konstytucyjnego KUL oraz Wydział Nauk Prawnych Towarzystwa Naukowego KUL.
Sprawozdanie z Walnego Zebrania Stowarzyszenia Kanonistów Polskich
Authors: Słowikowska Anna
Published: August 2023

Dnia 7 września 2013 r. w Auli im. Biskupa Czesława Kaczmarka Wyższego Seminarium Duchownego w Kielcach odbyło się statutowe posiedzenie Walnego Zebrania Stowarzyszenia Kanonistów Polskich, któremu przewodniczył ks. prof. dr hab. Józef Krukowski, prezes SKP.
Ś.p. Ks. Kan. dr Stanisław Cierkowski (1970-2013)
Authors: Romanko Agnieszka
Published: August 2023

Ks. kan. dr Stanisław Cierkowski urodził się w 8 maja 1970 r. Pochodził z Mroczna (województwo mazursko-warmińskie).
Ś.p. Ks. Infułat dr Józef Wójcik (1934-2014)
Authors: Krukowski Józef
Published: August 2023

Ks. Józef Wójcik urodził się 2 listopada 1934 r., w Gałkach Krzczonowskich k. Gielniowa. Po uzyskaniu świadectwa dojrzałości wstąpił do Wyższego Seminarium Duchownego w Sandomierzu. Po odbyciu studiów teologicznych w 1958 r. przyjął święcenia kapłańskie z rąk ks. bpa Jana Kantego Lorka. W latach 1964-1967 odbył studia na Wydziale Prawa Kanonicznego Akademii Teologii Katolickiej w Warszawie, gdzie w 1971 r. uzyskał stopień doktora nauk prawnych w zakresie prawa kanonicznego na podstawie pracy napisanej pod kierunkiem ks. prof. Mariana A. Myrchy.
Nowe kompetencje Trybunału Roty Rzymskiej
Authors: Góralski Wojciech
Published: August 2023

On 30 August 2011 Pope Benedict XVI issued motu proprio “Quaerit semper” ( came in to force on 1 October of the same year ), pursuant to which he transferred competences concerning obtaining super rato et non consummato dispensation and cleelaring invalidity of holy orders – from Congregation for Divine Worship and the Discipline of the Sacraments to the Tribunal of the Roman Rota by establishing a new office in this Tribunal. The introductory part of motu proprio contains motives of introduced innovations (among others directives of II Vatican Council), and the second part contains proper legal dispositions (in four articles), which amend provisions of Pastor bonus, Apostolic Constitution by John Paul II of 28 June 1988.
Specyfika aktów występujących w kanonach 119 i 127 Kodeksu Prawa Kanonicznego
Authors: Dzierżon Ginter
Published: August 2023

An issue of the specific nature of the acts in can. 119 and 127 in the Code of Canon Law 1983 was shown in the article. There is difference between these two acts. Can. 119 relates to the collegial act while can. 12 7 relates to the a et o f a superior. In the a et o f a superior there is separation of the superior and college or group of persons. The Author indicated that collegial acts relate to the juridic persons. Acts of a superior relate to place certain acts by the superior. The participation of the college or group of people helps to make an objective decision.
Ś.p. Józef Kardynał Glemp Prymas Polski (1929-2013)
Authors: Wierzbicki Piotr
Published: August 2023

Ks. Józef kard. Glemp, Arcybiskup Metropolita Gnieźnieński (1981-1992), Arcybiskup Metropolita Warszawski (1981-2007), Prymas Polski (1981-2009), członek honorowy Stowarzyszenia Kanonistów Polskich.
Odpowiedzialność cywilnoprawna z tytułu czynności dokonywanych drogą elektroniczną
Authors: Bierć Andrzej , Zieliński Marcin Z.
Published: August 2023

Autor przedstawia odpowiedzialność cywilną za czynności dokonywane drogą elektroniczną. Artykuł składa się z czterech części. W części pierwszej, zatytułowanej „wstęp”, wskazano główne założenia tego artykułu. Autor koncentruje się na czynnikach wpływających na sytuację prawną osób zainteresowanych elektronicznymi czynnościami prawnymi. Głównym celem drugiej części artykułu jest scharakteryzowanie czynności prawnych za pośrednictwem systemu elektronicznego. Co do zasady, w elektronicznym obrocie prawnym nie jest konieczne składanie oświadczenia woli w formie pisemnej wymaganej dla ważności transakcji. Co więcej, wiele aktów prawnych przewiduje możliwość złożenia oświadczenia woli zarówno w formie elektronicznej, jak i tradycyjnej. Autor w części trzeciej przedstawia wiele obowiązujących systemów prawa. W prawie prywatnym proces harmonizacji porządków prawnych jest coraz bardziej widoczny. Wszystko ze względu na prawo Unii Europejskiej. W konsekwencji obowiązują dwa porządki prawne: prawo krajowe (prawo prywatne) i prawo międzynarodowe. W tworzeniu tak wielopłaszczyznowego porządku prawnego nie bez znaczenia jest także orzecznictwo Europejskiego Trybunału Praw Człowieka w Strasburgu, Europejskiego Trybunału Sprawiedliwości oraz Sądu Pierwszej Instancji w Luksemburgu. Na koniec autor wskazuje przesłanki odpowiedzialności cywilnej, odwołując się do zjawisk obiektywnych. Autor przewiduje, że po kodyfikacji nowego kodeksu cywilnego zaostrzy się odpowiedzialność cywilna za czynności prawne dokonywane drogą elektroniczną.
Sprawozdanie z uroczystości wręczenia Nagrody im. Księdza Idziego Radziszewskiego ks. prof. Józefowi Krukowskiemu. Lublin, dnia 16 maja 2012 roku
Authors: Lewicka Mariola
Published: August 2023

Towarzystwo Naukowe Katolickiego Uniwersytetu Lubelskiego, instytucja naukowo-wydawnicza, skupiająca ponad 700 członków z kraju i z zagranicy, przyznaje od 1974 roku Nagrodę im. Ks. Idziego Radziszewskiego, założyciela i pierwszego Rektora KUL, wybitnym twórcom nauki za całokształt pracy naukowej, dydaktycznej i organizacyjnej.
Zmiany ilościowe w systemie szkolnictwa wyższego w III Rzeczypospolitej
Authors: Hermanowicz Małgorzata
Published: August 2023

Przemiany polityczne, społeczne i gospodarcze, które dokonują się w Polsce od 1989 roku, stały się podstawą zmian w systemie szkolnictwa wyższego. Szczególnie młodzi ludzie wykazywali zainteresowanie edukacją, ponieważ mieli ograniczone szanse na znalezienie atrakcyjnej i dobrze płatnej pracy. Dlatego ewolucja w zakresie szkolnictwa wyższego charakteryzowała się szybkim popytem na szkolnictwo wyższe. W efekcie tych wymagań społecznych nastąpił wzrost liczby szkół wyższych. W latach 1990-2007 powstały 42 szkoły publiczne i 322 szkoły niepubliczne. System finansowania szkolnictwa wyższego w Polsce dokonuje podziału na szkoły publiczne finansowane z budżetu państwa oraz szkoły niepubliczne, które sporadycznie pozyskują środki na działalność statutową. Rozwój kadry naukowej nie jest stabilny i wykazuje tendencję do starzenia się. Spadek przyrostu naturalnego nie sprzyja rozwojowi uczelni niepublicznych, których dochody pochodzą głównie z opłat pobieranych od studentów.
Prevalence of lower limb pain and disability in football, hockey, and floorball players
Authors: Hagovská Magdaléna , Buková Alena , Takáč Peter
Published: August 2023

BACKGROUND: Currently there are not enough studies that compared frequent types of collective sports with regard to the prevalence of pain and disability of the lower limb. OBJECTIVE: To determine the prevalence of lower limb pain and disability in team sports players. METHODS: 388 athletes with average age 27.26 ± 4.69, from sports clubs at the national level were included in the study. The Oxford Hip Score was used to determine the prevalence of hip pain. The International Knee Documentation Committee was used to determine the prevalence of knee pain. The Foot and Ankle Disability Index was used to determine the prevalence of ankle pain. RESULTS: Hockey players had a prevalence of hip pain of 97.2% and a 14.3 times higher risk of developing hip pain compared with football and floorball players. Floorball players had a 81.9% prevalence of knee pain, with a 3.8 times higher the risk of knee pain compared with football and hockey. Floorball players had a 62.3% prevalence of ankle pain and a 1.8 times higher the risk of developing ankle pain compared with football and hockey players. CONCLUSIONS: The highest percentage of knee 81.9% and ankle 62.3% pain, as well as the greatest risk of pain, was found among floorball players. Hockey players had the highest prevalence (97.2%) and risk of developing hip pain.
Numberings, c.e. oracles, and fixed points
Authors: Faizrahmanov Marat
Published: August 2023

The Arslanov completeness criterion says that a c.e. set A is Turing complete if and only there exists an A-computable function f without fixed points, i.e. a function f such that [Formula: see text] for each integer  x. Recently, Barendregt and Terwijn proved that the completeness criterion remains true if we replace the Gödel numbering [Formula: see text] with an arbitrary precomplete computable numbering. In this paper, we prove criteria for noncomputability and highness of c.e. sets in terms of (pre)complete computable numberings and fixed point properties. We also find some precomplete and weakly precomplete numberings of arbitrary families computable relative to Turing complete and non-computable c.e. oracles respectively.
Punctually presented structures I: Closure theorems
Authors: Dorzhieva Marina , Melnikov Alexander
Published: August 2023

We study the primitive recursive content of various closure results in algebra and model theory, including the algebraic, the real, and the differential closure theorems. In the case of ordered fields and their real closures, our result settles a question recently raised by Selivanova and Selivanov.
Dementia prediction using novel IOTM (Internet of Things in Medical) architecture framework
Authors: Pavitra B. , Singh D. Narendar , Sharma Sudhir Kumar , Hashmi Mohammad Farukh
Published: August 2023

In the last decades the health care developments highly rise the level of ages of world population. This improvement was accompanied by increasing the diseases related with elder like Dementia, which Alzheimer’s disease represents the most common form. The present studies aim to design and implementation a medical system for improving the life of Alzheimer’s disease persons and ease the burden of their caregivers. AI is transforming the practice of medicine. It’s helping doctors diagnose patients more accurately, make predictions about patient’s future health, and recommend better treatments. AI goes beyond the foundations of deep learning to give you insight into the nuances of applying AI to medical use cases. Diagnosis is about identifying disease. By building an algorithm we can diagnosis chest X-ray and determine whether it contains disease, another algorithm that will look at brain MRIs and identify the location of tumours in those brain MRIs health of the patients lab values and their demographics and use those to predict the risk of an event. A Smart IOT Interactive Assistance is a technological device that continuously monitors the stability of an Alzheimer’s patient, indicates their position on a map, automatically reminds them to take their prescriptions, and has a call button for any emergencies they could experience during the day. The system has two components, one of which the patient wears and the other of which is an IoT platform application utilized by the caregiver. The motion processing unit sensor, GPS, heart rate sensor with microcontrollers, and LCD display were used to construct the wearable device. An Internet of Things (IoT) platform supports this device, allowing the caregiver to communicate with the patient from any location.
Digital image processing for evaluating the impact of designated nanoparticles in biomedical applications
Authors: Baazeem Rami , Maheshwary Priti , Binjawhar Dalal Nasser , Gulati Kamal , Joshi Shubham , Ojo Stephen , Pareek Piyush Kumar , Shukla Prashant Kumar
Published: August 2023

Nanomaterials are finding increasingly diverse medical uses as technology advances. Researchers are constantly being introduced to new and improved methods, and these applications see widespread use for both diagnostic and therapeutic purposes. Early disease detection, efficient drug delivery, cosmetics and health care products, biosensors, miniaturisation techniques, surface improvement in implantable biomaterials, improved nanofibers in medical textiles, etc. are all examples of how biomedical nanotechnology has made a difference in the medical field. The nanoparticles are introduced deliberately for therapeutic purposes or accidentally from the environment; they will eventually reach and penetrate the human body. The exposed nanoparticles interact with human blood, which carries them to various tissues. An essential aspect of blood rheology in the microcirculation is its malleability. As a result, nanomaterial may cause structural abnormalities in erythrocytes. Echinocyte development is a typical example of an induced morphological alteration. The length of time it takes for these side effects to disappear after taking a nano medication also matters. Haemolyses could result from the dangerous concentration. In this experiment, human blood is exposed to varying concentrations of chosen nanomaterial with potential medical applications. The morphological modifications induced were studied by looking at images of erythrocyte cells. That’s a picture of a cell taken using a digital optical microscope, by the way. We used MATLAB, an image-analysis programme, to study the morphometric features. Human lymphocyte cells were used in the cytotoxic analysis.
Temporal cross-correlation between Polar® heart rate monitor interface board and ECG to measure RR interval at rest
Authors: Materko Wollner , dos Reis Façanha Caio Cesar , Guedes Gizelly Coelho , Dias Marcela Fabiani Silva , Costa Alisson Vieira , Belfort Dilson Rodrigues , da Pureza Demilto Yamaguchi , Alberto Alvaro Adolfo Duarte
Published: August 2023

BACKGROUND:

A Polar heart rate monitor is a device that measures RR intervals, but has not been correlated to accurately measure the series of RR interval signals between the ECG and the Polar[Formula: see text] Heart Rate Monitor Interface (HRMI) Board at rest.

OBJECTIVE:

The aim of the study was to evaluate the temporal cross-correlations between the Polar[Formula: see text] HRMI Board and an ECG to measure the series of RR intervals at rest.

METHODS:

The sample consisted of eighteen healthy male subjects and they were instructed to lie in the supine position at rest while breathing normally and a time window of the last 2 min was recorded to analyse RR intervals were obtained for each subject with a Polar[Formula: see text] HRMI Board and an ECG. Cross-correlation analysis of RR interval signals between methods and reliability was expressed by Bland and Altman analysis.

RESULTS:

The cross-correlation was excellent, resulting in a mean of 0.98 [Formula: see text] 0.01 and no lag or delay between the signals. The bias was 0.03 [Formula: see text] 0.08 s or 8.0% for MeanRRi from Polar[Formula: see text] HRMI Board and ECG, no significant difference.

CONCLUSIONS:

The Polar[Formula: see text] HRMI Board is acceptable for assessment of serial RR intervals. The results support the reliability of the Mean RR interval compared to a resting ECG.
Circulating Exosomes from Alzheimer’s Disease Suppress Vascular Endothelial-Cadherin Expression and Induce Barrier Dysfunction in Recipient Brain Microvascular Endothelial Cell
Authors: Bei Jiani , Miranda-Morales Ernesto G. , Gan Qini , Qiu Yuan , Husseinzadeh Sorosh , Liew Jia Yi , Chang Qing , Krishnan Balaji , Gaitas Angelo , Yuan Subo , Felicella Michelle , Qiu Wei Qiao , Fang Xiang , Gong Bin
Published: August 2023

Background:

Blood-brain barrier (BBB) breakdown is a crucial aspect of Alzheimer’s disease (AD) progression. Dysfunction in BBB is primarily caused by impaired tight junction and adherens junction proteins in brain microvascular endothelial cells (BMECs). The role of adherens junctions in AD-related BBB dysfunction remains unclear. Exosomes from senescent cells have unique characteristics and contribute to modulating the phenotype of recipient cells. However, it remains unknown if and how these exosomes cause BMEC dysfunction in AD.

Objective:

This study aimed to investigate the impact of AD circulating exosomes on brain endothelial dysfunction.

Methods:

Exosomes were isolated from sera of AD patients and age- and sex-matched cognitively normal controls using size-exclusion chromatography. The study measured the biomechanical nature of BMECs’ endothelial barrier, the lateral binding forces between live BMECs. Paracellular expressions of the key adherens junction protein vascular endothelial (VE)-cadherin were visualized in BMEC cultures and a 3D BBB model using human BMECs and pericytes. VE-cadherin signals were also examined in brain tissues from AD patients and normal controls.

Results:

Circulating exosomes from AD patients reduced VE-cadherin expression levels and impaired barrier function in recipient BMECs. Immunostaining analysis demonstrated that AD exosomes damaged VE-cadherin integrity in a 3D microvascular tubule formation model. The study found that AD exosomes weakened BBB integrity depending on their RNA content. Additionally, diminished microvascular VE-cadherin expression was observed in AD brains compared to controls.

Conclusion:

These findings highlight the significant role of circulating exosomes from AD patients in damaging adherens junctions of recipient BMECs, dependent on exosomal RNA.
An integrated method for multi-attribute group decision-making based on the linguistic Z-number and MSM operators
Authors: Chen Bo , Cai Qiang , Wei Guiwu , Mo Zhiwen
Published: August 2023

This article extends the ordered weighted average operator (OWA) in the linguistic Z-number (LZN) environment, increasing attention to the distribution of data itself, and this idea can also be combined with other operators. Specifically, for the weight of data, this paper gives consideration to both the preference of attributes and the distribution of data itself, gives the interval distribution induced OWA operator (IDIOWA), and combines the weight of attributes to obtain the LZN interval distribution induced hybrid weighted average operator (LZIDIHWA) in LZN environment. Then, it introduces some good properties of this operator. At the same time, the LZN interval distribution induced weighted Maclaurin symmetric means operator (LZIDIWMSM) is obtained by combining LZN interval distribution induced OWA operator (LZIDIOWA) with the LZN weighted Maclaurin symmetric means operator (LZWMSM), which makes up for the defect that LZWMSM cannot be used for data integration alone. Finally, the two operators are used for multi-attribute group decision-making (MAGDM), and their effectiveness is verified by comparative analysis.
Identifying pain and distress in non-verbal persons with intellectual disability: Professional caregivers’ and parents’ attitudes towards using wearable sensors
Authors: Øderud Tone , Boysen Elin S. , Strisland Frode , Dahl Inger-Lise , Kildal Emilie , Hassel Bjørnar , Morland Cecilie
Published: August 2023

BACKGROUND:

Persons with severe intellectual disability (ID) may be non-verbal and unable to communicate pain or distress. Consequently, painful conditions may go undetected, and non-verbal persons with ID may not receive adequate care and treatment.

OBJECTIVE:

This study aims to explore how professional caregivers and parents identify pain and distress in non-verbal persons with ID, and their attitudes towards using wearable sensors to identify pain and distress in daily life situations.

METHODS:

Exploratory, mixed method study. Caregivers (83) answered an online questionnaire, and professional caregivers (18) and parents (7) were interviewed.

RESULTS:

Professional caregivers and parents recognise pain and distress from observations and behavioural signs that are often equivocal. They experience that this is inadequate to reliably detect pain and distress in non-verbal persons with ID. Professional caregivers and parents’ express frustration and fear that painful conditions may remain untreated. They are positive towards using wearable sensors on condition that sensors do not infringe on user autonomy and privacy.

CONCLUSIONS:

There is a need for sensors and methods that can objectively identify pain and distress and ensure adequate treatment, that may improve quality of life of non-verbal persons with ID.
CHANGES IN MARKERS OF NEURO-IMMUNE DISINTEGRATION IN THE SUB-ACUTE PHASE OF ISCHEMIC STROKE
Authors: Stoyanov O. M. , Khramtsov D. M. , Vikarenko M. S. , Gruzevskyi O.A.
Published: August 2023

Background. The increase in the prevalence of CVZ gives reasons to consider the problem of combating stroke as a priority area of treatment and prevention work of medical workers all over the world.

Aim: assessment of the role of changes in markers of neuroimmune disintegration in the acute phase of ischemic stroke.

Material and methods. The study was conducted on the basis of the clinical units of the Medical Institute of the Black Sea National University named after Peter Mohyla (Mykolaiv, Odesa) in 2020-2022. At the first stage, a retrospective analysis of 150 disease histories of patients who underwent II and were undergoing rehabilitation at the "Expert Health" medical center was carried out. At the second, prospective stage, 28 patients who had II in the subacute period were examined with an in-depth immunological examination. An analysis of the dynamics of leukogram indicators, CRP, procalcitonin and other markers of inflammation was carried out. At the prospective stage, the blood content of pro-inflammatory cytokines (TNF, IL1, IL2, Il6) and anti-inflammatory cytokines (IL4, IL10) was additionally determined. Statistical processing was carried out by methods of dispersion and correlation analysis using Statistica 14.0 software (TIBCO, USA).

Results. According to the retrospective analysis, the severity of changes in leukogram and CRP content correlated with the severity of II (r=0.11-0.29). With an average NIHSS score of 10.8±0.9, the content of lymphocytes in the peripheral pool averaged 17.3±0.4%, while the total content of leukocytes was 9.4±0.2 G/l. 76 (50.7%) patients had records in their medical records regarding the assessment of the CRP level, which averaged 7.7±0.9 mg/l. In 72.7% of patients, manifestations of atherosclerosis of brachiocephalic vessels were determined, including in 31.3% - signs of critical stenosis of the carotid arteries. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31).

It is shown that in the subacute period at the stage of rehabilitation, the leukogram normalizes, the manifestations of the systemic inflammatory response decrease. At the same time, there are signs of stress on neuroimmune regulatory mechanisms and the need to monitor inflammatory biomarkers both in the acute and subacute stages of stroke.

Conclusions. The expressiveness of changes in leukogram and CRP content correlates with the severity of II, and high levels of CRP are a predictor of an adverse clinical outcome. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31). With an ischemic stroke, neuroimmune regulatory mechanisms are stressed in the subacute stage of the disease. It is advisable to monitor inflammatory biomarkers both in the acute and subacute stages of stroke.
PATHOGENETICALLY DIRECTED METHOD OF PREVENTION AND TREATMENT OF AGE-MACULAR DEGENERATION
Authors: Saldan Y. R. , Panchenko Y.O. , Malachkova N.V.
Published: August 2023

Background. Age-related macular degeneration is one of the most common causes of blindness in developed countries, especially in people over 60 years old. The incidence of AMD is projected to increase to 288 million in 2040 compared to 196 million in 2020. Cardiovascular factors, smoking, alcohol consumption, overweight, genetic factors, and metabolic disorders are risk factors for the development of AMD. There are disorders of lipid metabolism, as well as hyperreactivity of platelet purine receptors may be associated with the progression of AMD. The AREDS2 formula is currently used to treat AMD. New therapeutic strategies aimed to correct metabolic disorders are needed to decrease the development of the late stages of AMD.

Aim: to investigate the effectiveness of improving pathogenetically directed method of prevention and treatment of age-related macular degeneration.

Materials and methods. We observed 40 patients (80 eyes), aged 50-85 years, with AMD of category 3 (intermediate AMD), who were divided into 2 groups. The main group included 20 patients (40 eyes), 14 women and 6 men, who have prescribed a complex drug according to the standard AREDS2 scheme, as well as fenofibrate (200 mg) and clopidogrel bisulfate (75 mg). The control group included 20 patients (40 eyes), 13 women and 7 men. These patients received AREDS2 standard treatment. Progression was evaluated according to the results of OCT of the macular area according to the AREDS classification and control of corrected visual acuity (CVA). The observation period was 2 years.

Results. No signs of progression were noted in patients of both observation groups within 6 months from the start of the prescribed therapy. In the patients of the control group, the progression of the disease was recorded after 1 year of observation according to both defined criteria. Changes in OCT were observed in 7,5% of patients in the control group, and a decrease in CVA- in 5%. In the patients of the main group who used the extended therapeutic regimen, after 1 year of follow-up, progression according to OCT signs was noted in 2,5% of cases, but there was no worsening of CVA. After 2 years of observation, signs of progression according to OST were recorded in the main group by 50% less than in the control group. According to CVA, disease progression was detected in 15% of the main group and 30% of the control group.

Conclusions. This study complemented already existing therapeutic strategies for the preventive treatment of AMD.
THE WORK’S FEATURES OF MAXILLO-FACIAL SURGEONS OF KYIV AND REGION DURING THE MARTIAL LAW
Authors: Palyvoda R. , Kaniura O. , Kopchak A.
Published: August 2023

Background. Maxillofacial surgery, which took place in Ukraine as a separate legally recognized specialty, daily acquires its relevance. Treatment of inflammatory, oncological diseases, congenital malformations, defects and deformities of the face touches the person's face, which has not only medical and aesthetic, but also social significance in society. The question arises of the readiness of the personnel reserve for such a load and modern challenges.

Aim: to analyze the peculiarities of the work of maxillofacial surgeons in Kyiv and the Kyiv region during wartime, and to identify the main problems they face in their work in connection with the existing realities and to determine ways to overcome them based on the data of an anonymous questionnaire.We have developed a questionnaire on the GoogleForm platform, concerning training and advanced training of specialists, theoretical and practical aspects of the treatment of gunshot and mine-explosive trauma, as well as receiving volunteer assistance to clinical hospitals. The study involved 39 doctors of the maxillofacial profile У дослідженні прийняли участь 39 maxillo-facial surgeons and trainee from Kyiv city and Kyiv region.

Materials and methods. It was determined that doctors watched webinars (69,2%) or read specialized literature on the treatment of gunshot trauma (56,4%). for up-to-date professional information. Most (23.1%) of respondents experience a lack of qualifications when performing secondary reconstructive interventions and rehabilitation of patients with mine-explosive/gunshot. At the same time, 61.5% of doctors conducted online consultations with foreign colleagues, 48.7% - ensured the visit of foreign colleagues to their department.

Conclusion. Definitely important point is the preparation of qualified human resources in the field of maxillo-facial surgery, a special condition for development is the communication of domestic specialists with international professional community.
RETROSPECTIVE ANALYSIS OF MEDICAL CHARTS OF PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME
Authors: Savytskyi V. I.
Published: August 2023

Background. Antiphospholipid attracts the attention of clinicians in various fields of medicine. This pathology is characterized by a triad of clinical and laboratory signs: recurrent venous or arterial thrombosis with localization in any part of the bloodstream, obstetric pathology in the form of primary premature pregnancy and intrauterine death of the fetus with hematological disorders (thrombocytopenia, hemolytic anemia).

Aim: to conduct a retrospective analysis of medical records of patients with antiphospholipid syndrome.

Materials and methods. A retrospective analysis of outpatient/inpatient medical records of 54 patients with the main diagnosis: antiphospholipid syndrome between 2016 and 2021, who were examined and treated in the rheumatology department of the Multidisciplinary Medical Center of Odesa National Medical University, was conducted. The diagnosis of antiphospholipid syndrome was established according to the recommendations of EULAR (2019), Order of the Ministry of Health of Ukraine dated October 8, 2007 No. 626 "Clinical protocol for providing medical care to patients with Antiphospholipid Syndrome" and Order of the Ministry of Health of Ukraine No. 22 dated January 20, 2015. "Clinical protocol for providing medical care to patients with immune diseases."

Results. In the general group of patients, the duration of this pathology at the time of the study ranged from 1 to 10 years. It was established that the number of appeals in connection with exacerbation of antiphospholipid syndrome depended on age and had probable differences. It was also noted that the total number of concomitant pathologies was correlated with the number of appeals regarding exacerbation of antiphospholipid syndrome. It was revealed that arthralgia and polyarthritis were most often detected in male patients aged 20-44 against the background of antiphospholipid syndrome, and skin manifestations in men aged 45-59. In women of the age group of 20-44 years, on the background of the diagnosed antiphospholipid syndrome, skin manifestations in the form of reticular liver, arthralgia and polyarthritis, as well as cardiovascular disorders, were most often noted. In women aged 45-59, arthralgia and polyarthritis and disorders of the cardiovascular system.

 Using the method of collecting anamnestic data and the results of clinical laboratory examination, in accordance with current medical care protocols and diagnostic criteria for antiphospholipid syndrome, a retrospective analysis confirms the fact that antiphospholipid syndrome occurs 5 times more often in women than in men.
The Steep Road to Renewal of Islamic Law through Maqasid Values
Authors: Faishal Nur Ahmad , Effendi Orien
Published: August 2023

Hukum Islam secara substantif berasal dari ajaran agama Islam. Sebagai ajaran agama, hukum Islam bersumber dari Allah yang digali langsung dari al-Qur’an dan al-Sunnah. Hukum Islam ini kemudian dinilai sebagai suatu yang sakral dan tidak dapat diubah. Pikiran inilah yang kemudian menjadikan hukum Islam itu menjadi kaku bahkan statis dan pada akhirnya tidak siap menjawab berbagai persoalan, padahal hukum Islam dalam realitas kehidupan manusia menuntut terjadinya dinamisasi dan perkembangan secara terus menerus. Dinamisasi hukum Islam akan tercapai manakala terjadi dialektika antara teks dan realitas, dengan begitu selalu menemukan inovasi baru dalam rangka penemuan hukum, tujuannya agar meraih kemaslahatan. Artikel ini menggunakan studi analisis melalui penelitian pustaka berdasarkan data primer dan sekunder dengan pendekatan normatif yuridis. Hasil penelitian menujukan bahwa masih terdapat kalangan umat Islam yang menganggap kesakralan hukum Islam klasik sebagai sebuah kebenaran absolut yang tidak dapat diubah, sikap sebagian kalangan tersebut menjadikan Islam terasa asing bagi lingkungan yang melingkupinya. Keadaan semakin diperparah ketika mereka tidak menerima sepenuhnya terhadap pembaharuan hukum Islam seperti hadirnya konsep atau nilai maqashid kontemporer
KARAKTERISTIK DAN ATRIBUT PRODUK TERHADAP KEPUTUSAN PEMBELIAN JAMU GENDONG DI DESA KIRINGAN, JETIS, BANTUL, YOGYAKARTA
Authors: Sumarlin Beti Rias , Al Arifa Nur Saudah
Published: August 2023

Abstrak Penelitian ini bertujuan untuk mengetahui karakteristik dan atribut yang menjadi keputusan pembelian jamu gendong di Desa Kiringan. Jumlah responden sebanyak 100 orang yang dipilih secara acak. Metode analisis dalam penelitian ini menggunakan analisis deskriptif dan analisis fishbein. Hasil penelitian menunjukan bahwa konsumen jamu gendong di dominasi berjenis kelamin perempuan, rata-rata usia 21-30 tahun, berstatus menikah, pendidikan terakhir SMA, dan memiliki pendapatan perbulan < Rp.1.500.000,00. Atribut yang menjadi keputusan pembelian jamu gendong ada 11 atribut yaitu meliputi rasa, khasiat, komposisi, merek, kemasan, harga, keamanan, kemudahan dan ketersediaan. Atribut yang menjadi pertimbangan keputusan pembelian yaitu atribut khasiat, atribut rasa, dan atribut keamanan. Dengan total skor khasiat 8,05, rasa 6,57, keamanan 5,76. Hal ini menunjukkan bahwa konsumen sebelum membeli memperhatikan manfaat yang ada pada produk dan rasa yang menjadi pertimbangan pembelian ulang. Kata kunci : Karakteristik, Atribut, Jamu, Keputusan Pembelian