bluuebunny/crossref_metadata_2025 huggingface dataset:
A study on the narrative technique of ‘peeping’ and ‘eavesdropping’ in Korean long piece novel
Authors:   The Research Of The Korean Classic, Kim Mun-hee
Published: December 2023

The object of this study is to discuss function and effects of the narrative technique of ‘peeping’ and ‘eavesdropping’ in Korean long piece novel. In order to facilitate the study, the aspects of narrative, function and effects of ‘peeping’ and ‘eavesdropping’ in Sohyunseongrok, Youhyogon-gseonhengrok, Youssisamdaerok, Hyunmongssangyongki, Jossisamdaerok, Seonghyungongsukyeolki, Imssisamdaerok are discussed. Those novels belongs to a subtype of Korean Long piece novel, Samdaerok long piece novel. First, the narrative aspects of ‘peeping’ and ‘eavesdropping’ in Korean long piece novel are divided into catalyst narrative of captivation and lovesick, catalyst narrative of conspiracy and misunderstanding, catalyst narrative of settlement and disillusion and catalyst narrative of relief and laughter in respect of situation, subject, object and its result. Furthermore, their characteristics are analyzed. The narrative technique of ‘peeping’ and ‘eavesdropping’ in Korean long piece novel accelerates or decelerates the rate of narrative progression in terms of narrative elements. It also diversifies narrative elements and terminates narrative. Moreover, it secures the function of probabilities simplifying the complicated framework of events in the long piece novel. The narrative technique of ‘peeping’ and ‘eavesdropping’ is able to illuminate reader’s desire allowing main agent’s desire of affection and acknowledgement in terms of bibliopsychology. Readers can relieve the curiosity of ‘peeping’ and ‘eavesdropping’ and feel amusing pleasure through main agent’s eyes and ears. Due to the function and effects mentioned above, ‘peeping’ and ‘eavesdropping’ have been used consistently in Korean long piece novel.
Narrative of the existence of historically-based, Seonhyeop(仙俠) female characters in Korean full-length novels
Authors:   The Research Of The Korean Classic, Kim Soo-youn
Published: December 2023

The purpose of this article is to examine the narrative characteristics of the female character of the Seonhyeop(仙俠, hermit martial arts) type, which became popular in the 18th century, and to examine the meaning of the appearance of this type of character in terms of the narrative grammar and genre possibilities of Korean full-length novels. If we look at the history of Korean classical novels, we can discover the phenomenon of meaningful character types being developed in earnest around specific genres in each era. Representative examples include ‘fantastic existence’ in biographical romance novels that appeared after the 10th century and ‘evil woman-type characters’ in early full-length novels after the 17th century.
In the 18th century, Korean full-length novels with a large volume were popular, and one of the newly emerging character types at this time was the Seonhyeop type character. This character can be further classified into good and evil people, Confucian and Taoist people, civilized and martial people, internal and external, Taoist and martial arts practitioners, and so on. However, one character does not embody only one type, but is embodied by combining several types of personality.
Among them, if we divide the narrative of the existence of Seonhyeop female character character based on history into the image of Taoist and martial arts, the narrative of the loser of history, and the discourse of loyalty in rebellion. Each shows the characteristics of combining peripheral properties, recalling memories of others, and aiming for the voice of non-relationship and marginal members. These character characteristics form one of the important narrative grammars of Korean full-length novels, and reveal the possibility of genre expansion in that they are connected to the epics of heroism and martial arts novels that appeared in later generations. In particular, we can discover the early aspects of martial arts novels that are still popular to this day. Representative examples include the way of revealing the ability for Seonhyeop, the establishment of relationships centered on factions, and the nature of the argument between right and evil.
The highlighting of the character of the Seonhyeop type can be said to be a discourse event in that it discovers and embodies an object that had not been seen and a voice that had not been heard in previous novels. The world expressed in language makes invisible beings visible and reorganizes the proportion and division ratio of voices participating in the world we live in. It is a self-organizing method of the novel that is unrelated to the author’s conscious intention. Among the voices aimed at by the author, the novel’s expansion of the voices of new characters testifies to the situation at the time and at the same time reflects the voices distributed among members of society. It can be said to be an event that brings about a change in the share of.
A Study on Lee, Gyujun’s Travel Records
Authors:   The Research Of The Korean Classic, Jeong Young-moon
Published: December 2023

Lee, Gyujun (1855-1923) was a philosopher of the Joseon Dynasty and an Oriental medicine scholar who developed modern Oriental medicine based on clinical experiments. He lived during the late Joseon Dynasty and the Japanese colonial period and sometimes traveled for the purpose of sightseeing. During his time in Joseon, Confucian ideology was on the decline, and Western civilization was gaining influence due to modernization efforts. This period of both spiritual and material transition led to societal upheaval. And he tried to understand these problems through conver-sations with senior Confucian scholars.
Since the senior Confucian scholar he sought to converse with lived far away, he planned and carried out a long-distance trip to meet him. As a result, he was able to travel to many regions, including Songnisan Mountain, Jeoksangsan Mountain, Gyeryongsan Mountain, the east coast, Geumgangsan Mountain, and Seoul, and wrote about his experiences and impressions at those travel destinations in Chinese poetry such as 〈Seoyu Nojeonggi(西遊路程記)〉(1901), 〈Geumgang Ilgi(金剛日記)〉(1902), 〈Ipgayasangi (入伽倻山記)〉(1909), 〈Hoyu Ilgi(湖遊日記)〉(1911), 〈Hosangjaeyu Ilgi(湖上再遊日記)〉(1913), and 〈Gyeongdoji(京都志)〉(1901).
His diary entries were not daily records of activities but focused on significant events. While he did not record a wide range of content in his travelogues, he approached his subjects by selecting and documenting only ‘reliable information.’ These records were compiled and published as 『Seokgoksango』 through the final editing by Son, Jingyu. In this study, the researcher examined the significance of Lee, Jingyu’s travels and the characteristics of his travel records, focusing on 『Seokgoksango』.
A Study on the Bricoleur Conversion in the Culture of Agriculture and the meaning of Cooperation in the tale of 〈A Red bean Soup Granny and a Tiger〉
Authors:   The Research Of The Korean Classic, Jeon Ju-hee
Published: December 2023

This article is focused on the culture of agriculture and the characters’ cooperation in the tale of 〈A Red Bean Porridge Granny and A Tiger〉. These characters’ conflicts in the whole story can be sorted out into two types which are the conflict of a granny and a tiger, and one of a tiger and several non-human characters who lived in the granny’s home. This second conflict involves the cooperation of the granny and non-human characters. The potter, here, is triggered by the laboriousness of farming that the granny feels, and the latter is induced by sharing the red bean porridge that the granny made. These conflicts have significant meaning because both of them are universal experiences humans have gone through in history and the laboriousness of farming is eventually connected to the joy of redbean crops. This study is, especially interested in the behavior of cooperation because it can occur only with those whom you want and choose, and cooperation relationship also always visualize their relation and its effects unlike conflict relationship is not always visualized in their relations that can be with anyone. That is, cooperation has a reasonable background and purpose.
With these perspectives, the story can be analyzed as revolving around the aspect of characters’ cooperation in the second chapter, and showed that their cooperation set can be considered ‘bricoleur conversion’. In the third chapter, this article suggested that the granny’s laboriousness seemed to recall non-agriculture which symbolizes a tiger, however, it paradoxically verifies the power of agriculture that involves cyclical living culture, diversity, specialization, and cooperation of communities. The tale of 〈a red bean porridge granny and a tiger〉, therefore, is a metaphor featuring characters’ conflicts and cooperation and solar term, that about humans’ culture of agriculture that they have gone through with nature, labor, threat of enemies and their communities’ driving force to prevent themselves against any threats.
RNA polymerases IV and V are involved in olive fruit development
Authors: Serrano Alicia , Moret Martín , Fernández-Parras Isabel , Bombarely Aureliano , Luque Francisco , Navarro Francisco
Published: December 2023

Transcription is carried out in most eukaryotes by three multimeric complexes (RNA polymerases I, II and III). However, plants contain two additional RNA polymerases (IV and V), which have evolved from RNA polymerase II. RNA polymerases II, IV and V contain both common and specific subunits that may specialize some of their functions. In this study, we conducted a search for the genes that putatively code for the specific subunits of RNA polymerases IV and V, as well as the corresponding of RNA polymerase II in olive. Based on the homology with the genes of Arabidopsis thaliana, we identified 13 genes that putatively code for the specific subunits of polymerases IV and V, and 16 genes that code for the corresponding specific subunits of polymerase II in olive. The transcriptomic analysis by RNA-Seq revealed that the expression of the RNA polymerases IV and V genes was induced during the initial stages of fruit development. Given that RNA polymerases IV and V are involved in the transcription of long non-coding RNAs, we investigated their expression and observed relevant changes in the expression of this type of RNAs. Particularly, the expression of the intergenic and intronic long non-coding RNAs tended to increase in the early steps of fruit development, suggesting their potential role in this process. The positive correlation between the expression of RNA polymerases IV and V subunits and the expression of non-coding RNAs supports the hypothesis that RNA polymerases IV and V may play a role in fruit development throughout the synthesis of this type of RNAs.
Investigations on the Influence of Two Pyridyl-Mesoionic Carbene Constitutional Isomers on the Electrochemical and Spectroelectrochemical Properties of Group 6 Metal Carbonyl Complexes
Authors: Bens Tobias , Biprajit Sarkar
Published: December 2023

Metal complexes of mesoionic carbenes (MICs) of the triazolylidene-type and their derivatives have gained increasing attention in the fields of electrocatalysis and photochemistry. The redox-activity of these metal complexes is critical for their applications in both the aforementioned fields. Easy accessibility and modular synthesis open a wide field for the design of ligands, such as bidentate ligands. The combination of a MIC with a pyridyl unit in a bidentate ligand setup increases the π-acceptor properties of the ligands while retaining their strong σ-donor properties. The analogy with the well-established 2,2'-bipyridine ligand allows conclusions to be drawn about the influence of the mesoionic carbene (MIC) moiety in tetracarbonyl group 6 complexes in cyclic voltammetry and (spectro-)electrochemistry (SEC). However, the effects of the different connectivity in pyridyl-MIC ligands remains underexplored. Based on our previous studies, we present here a thorough investigation of the influence of the two different pyridyl-MIC constitutional isomers on the electrochemical and the UV-vis-NIR/IR/EPR spectroelectrochemical properties of group 6 carbonyl complexes. Moreover, the presented complexes were investigated for the electrochemical conversion of CO2 using two different working electrodes, providing a fundamental understanding of the influence of the electrode material in the precatalytic activation.
Recent Advances in Understanding COVID-19 Pathophysiology and Therapy: A Review
Authors: Rangraze Imran , Jhancy Malay , Khan Shehla
Published: December 2023

For over two years, the global COVID-19 pandemic has persisted, and its continuation is anticipated. The emergence and rapid spread of numerous new virus variations across continents have been observed. These variants, differing from previously known strains, manifest a spectrum of behaviors and clinical presentations, ranging from asymptomatic cases to severe illnesses and fatalities. Despite substantial research efforts in recent years, significant uncertainties persist in understanding the disease, encompassing variations in clinical outcomes, comorbidities, and challenges faced by individuals infected with COVID-19. Beyond the acute phase of infection, the prevalence of post-COVID-19 symptoms, often denoted as "long COVID," is notable, particularly in individuals recovering from the disease. Nevertheless, a research gap persists concerning the pathophysiological mechanisms underlying newly emerging viral variant infections, post-COVID-19 conditions, and the corresponding therapeutic strategies. This review is presented to analyze recent advancements in comprehending the pathophysiology and therapy of COVID-19.
On Sandy, Boron-Poor Soils, Liming Induced Severe Boron Deficiency and Drastically Reduced the Dry Matter Yield of Young Olive Trees
Authors: Arrobas Margarida , Raimundo Soraia , Conceição Nuno , Moutinho-Pereira José , Correia Carlos M. , Rodrigues M. Ângelo
Published: December 2023

In the Northeast of Portugal, like in many parts of the world, most soils are acidic, which may hamper crop productivity. This study presents the findings of a factorial experiment involving three factors: i) soil type [schist (Sch) and granite (Gra)]; ii) cultivars [Cobrançosa (Cob) and Arbequina (Arb)]; and iii) fertilizer treatments [liming (CaCO3) plus Mg (LMg), P application (+P), B application (+B), all fertilizing materials combined (Con+), and an untreated control (Con-)]. Dry matter yield (DMY) did not show significant differences between cultivars, but plants grown in schist soil exhibited significantly higher biomass compared to those in granite soil. Among the treatments, +B and Con+ resulted in the highest DMY (50.8 and 47.2 g pot-1, respectively), followed by +P (34.3 g pot-1) and Con- (28.6 g pot-1). Treatment LMg yielded significantly lower values (15.6 g pot-1) than Con-. LMg raised the pH above 7 (7.36), leading to a severe B deficiency. Although Con+ also raised the pH above 7 (7.48), it ranked among the most productive treatments for providing B. Therefore, when applying lime to B-poor sandy soils, moderate rates are advised to avoid inducing a B deficiency. Additionally, it seems prudent to apply B after lime application.
The Scale Invariant Vacuum Paradigm: Main Results and Current Progress Review (Part II)
Authors: Gueorguiev Vesselin G. , Maeder Andre
Published: December 2023

We present a summary of the main results within the Scale Invariant Vacuum (SIV) paradigm based on the Weyl Integrable Geometry (WIG) as an extension to the standard Einstein General Relativity (EGR). After a brief review of the mathematical framework, where we also highlight the connection between the weak-field SIV equations and the notion of un-proper time parametrization within the reparametrization paradigm, we continue with the main results related to early Universe; that is, applications to inflation, Big Bang Nucleosynthesis, and the growth of the density fluctuations within the SIV. In the late time Universe the applications of the SIV paradigm are related to scale-invariant dynamics of galaxies, MOND, dark matter, and the dwarf spheroidals where one can find MOND to be a peculiar case of the SIV theory. Finally, within the recent time epoch, we highlight that some of the change in the length-of-the-day (LOD), about 0.92 cm/yr, can be accounted for by SIV effects in the Earth-Moon system.
Where Does the EU-Path on NGTs Lead Us?
Authors: Bohle Finja , Schneider Robin , Mundorf Juliane , Zühl Luise , Simon Samson , Engelhard Margret
Published: December 2023

The broad and rapid application of new genomic techniques (NGTs) such as CRISPR-Cas has led to a fast increase in the number of genetically modified crops. With the recently published EU Commission’s (EC) regulatory proposal on plants generated with NGTs (July 5, 2023) the process of admission of such genetically modified plants is aimed to get accelerated and simplified. NGT plant applications shall be categorized based on their molecular characteristics into category 1 NGT (NGT1) and category 2 NGT (NGT2), which is in divergence from the current legislation centered around Directive 2001/18/EC. In the regulatory proposal NGT2 plants are envisioned to undergo a reduced risk assessment while for NGT1 plants no risk assessment is foreseen at all. To demonstrate were the path of the proposal leads to in practice, we applied the proposed criteria for categorization to a list of NGT plant applications that are currently in the commercialization pipeline. A key finding is that out of those plant applications affected by the EC proposal, 94% would be classified as NGT1 and thus would receive a market approval without risk assessment, monitoring and sufficient labeling provisions. The remaining 6% of applications would be classified as NGT2 plants for which, in deviation from the current regulation, an adapted risk assessment is proposed. A screening of intended traits in the pipeline highlights that certain NGT1 plants can pose similar environmental risks (e.g. invasiveness) compared to other genetically modified organisms (GMOs), as defined in Directive 2001/18/EC. For example, NGT1 applications based on RNAi technology can exhibit insecticidal effects with potential side effects on non-target organisms (i.e. other insects). Our quantitative and case-specific elaboration on how the current EC regulatory proposal would affect the environment, health or consumer protection will be informative for decision makers and politicians.
Unscented Kalman filter Sensorless Permament Magnet Synchronous Motor Model Predictive Control
Authors: Janiszewski Dariusz
Published: December 2023

The paper deals with the Model Predictive Control (MPC) algorithm as applied to the 1 sensorless control of a Permanent Magnet Synchronous Motor (PMSM). The proposed estimation 2 strategy, based on the unscented Kalman filter (UKF), uses only the measurement of the motor current 3 for the online estimation of speed, rotor position and load torque. Information about the system 4 state feeds the MPC. Results verify the effectiveness and applicability of the proposed sensorless 5 control technique. An implementation in low speed direct drive astronomy telescope mount systems 6 is investigated.
A Review on 3D Scanners Studies for Producing Customized Orthoses
Authors: Silva Rui , Silva Bruna , Fernandes Cristiana , Morouço Pedro , Alves Nuno , Veloso António
Published: December 2023

When a limb suffers a fracture, rupture, or dislocation, it is traditionally immobilized with plaster. This may induce discomfort in the patient, excessive itching and sweating, which creates the growth of bacteria, leading to an unhygienic and difficulty to keep clean from treatment. Furthermore, if the plaster remains for a long period, it may cause lesions in the joints and ligaments. To overcome all these disadvantages, orthoses have emerged as important medical devices to help patients in rehabilitation, as well as for self-care of deficiencies in clinics and daily life. Traditionally, these devices are produced manually, which becomes time-consuming and error prone. From another point-of-view, it is possible to use imageology (X-ray or computed tomography) to scan the human body; a process that may help orthoses manufacturing but induces radiation to the patient. To overcome this great disadvantage, several types of 3D scanners, without any kind of radiation have emerged. This article describes the use of various types of scanners capable of digitizing the human body, to produce custom orthoses. Studies have shown that photogrammetry is the most used and most suitable 3D scanner for the acquisition of the human body in 3D. With this evolution of technology, it is possible to decrease the scanning time and it will be possible to introduce this technology in clinical environment.
Analyzing Unsafe Behaviors of Construction Frontline Workers Based on Structural Equation Modeling
Authors: Li Ying , Pei Jingjing , Wang Shuangyan , Luo Yun
Published: December 2023

The unsafe behavior of frontline workers at construction sites is the most important cause of construction accidents. This study proposed a comprehensive model of frontline workers' unsafe behaviors based on a systems perspective and used structural equation modeling (SEM) to explore the influence mechanisms between Objective Conditions (e.g., work environment, work climate, task complexity), Safety Management (e.g., safety education and training, safety reward and punishment regulations, safety inspection, safety technology disclosure, safety warning signs), Group Influence (propagation of unsafe behaviors among workers), Personal Perception (subjective judgment of operators on their safety knowledge and skills), and Unsafe Behaviors. Data from 460 frontline workers were collected through questionnaires and the correlation hypotheses were tested using SPSS 26.0 and Amos 26.0 software. The following conclusions were obtained: (1) Objective Conditions directly positively influence Safety Management, Group Influence, and Personal Perception, but indirectly negatively influence Unsafe Behavior; (2) Safety Management not only directly positively affects Personal Perception but also directly negatively affects Unsafe Behavior. However, the direct effect of Safety Management on Group Influence is not significant; (3) Group Influence has a direct positive effect on Unsafe Behavior, but the direct effect on Personal Perception is not significant; (4) The direct effect of Personal Perception on Unsafe Behavior is insignificant. These findings can be used as preliminary data to guide decision-makers or managers in construction companies to develop reasonable management plans to curb unsafe behaviors of frontline workers.
Sensitivity of Vanessa cardui to Temperature Variations: A Cost-Effective Experiment for Environmental Education
Authors: Granato Carmella , Campera Marco , Bulbert Matthew
Published: December 2023

Temperature increases mediated through climate change threaten the survival of species. It is of foremost importance to engage citizens and future generations in understanding the mechanisms through which temperatures imposes its affect. For educators though this is not straight forward as tools for examined the impact of temperature over the lifetime of an animal are prohibitively expensive. At the same time environmental educators need guidance on the appropriate study systems to use with a balance between the species having an obvious response and ensuring the outcomes are ethical and sustainable. In our study, we created and tested a cost-effective experiment meant to be used for environmental education purposes. More specifically, we tested the sensitivity of the Painted lady butterfly Vanessa cardui to temperature variations using a homemade incubator. We describe the design of this experiment and report findings on survival rate, morphological variations, pupation time, and wingspan of adults across a range of biologically relevant temperatures. The information provided give educators options for testing a variety of hypotheses with regards to the impacts of temperature using an affordable and flexible set-up. Furthermore, the findings can be used by students to develop an understanding of the ramifications of the butterflies responses in an ecological context.
Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety
Authors: Melo Gonçalo M , Capucho Adriana M. , Sacramento Joana F. , Ponce-de-Leão José , Fernandes Marcos V. , Almeida Inês F. , Martins Fátima O. , Conde Silvia V.
Published: December 2023

Maternal obesity and gestational diabetes predispose to metabolic disturbances in the next generation. Moreover, the lactation phase also stands as critical for metabolic programming. Nevertheless, the precise mechanisms originating these changes remain unclear. Here we investigate the consequences of maternal diet lipid-rich diet during gestation and lactation, and its impact on metabolism and behavior in the offspring. Two experimental groups of Wistar female rats were used: a control group (NC) that fed a standard diet during gestation and lactation periods and an overnutrition group that fed a high-fat diet (HF, 60% lipid-rich) during the same phases. Offspring were analyzed at postnatal days 21, 28, and 2 months-old (PD21, PD28, PD60) for metabolic profile (weight, fasting glycemia insulin sensitivity, glucose tolerance) and euthanized for brain collection to evaluate by western blot markers of synaptic dynamics, metabolism and inflammation in the hypothalamus, hippocampus and prefrontal cortex. At 2 months-old, behavioral tests for anxiety, stress, cognition, and food habits were conducted. We observe that female offspring born from HF mothers exhibited increased weight gain and decreased glucose tolerance that attenuates with age. In offspring males, weight gain increased at P21 and worsened with age, while glucose tolerance remained unchanged. Offspring of HF mothers exhibited elevated levels of anxiety and stress during behavioral tests, displaying decreased predisposition for curiosity compared to the NC group. In addition, offspring from mothers with HF showed increased food consumption and a lower tendency towards food-related aggression. We conclude that exposure to HF diet during pregnancy and lactation induces dysmetabolism in the offspring accompanied by heightened stress and anxiety. There was sexual dimorphism in metabolic traits but not behavioral phenotypes.
Combined Potential of Quarry Waste Fines and Eggshells for the Hydrothermal Synthesis of Tobermorite at Varying Cement Content
Authors: Saldia Shem Quiawan , Bacosa Hernando P. , Vegafria Maria Cristina , Zoleta Joshua B. , Hiroyoshi Naoki , Calleno Christian Dagunsa , Cantong Wilyneth Sindico , Ibarra Ephraim , Aguilos Maricar , Amparado Ruben F
Published: December 2023

Quarry waste fines and eggshells are unavoidable wastes which relentlessly contribute to environmental load and pollution. Although a number of studies have suggested various methods for recycling, these wastes remain underutilized due to some technical constraints. In addition, no study has yet been explored on the possibility of combining quarry waste fines (QWF) and eggshell powder (ESP) for tobermorite synthesis. Tobermorite is the main component which primarily provides strength to the autoclaved aerated concrete products. For this purpose, this study seeks to evaluate the potential of QWF- ESP mix at 10%, 15% and 20% amounts of cement, respectively. The XRF, XRD, and TGA–DTA techniques were used to characterize the waste materials while physical and mechanical property tests and XRD analysis were performed on the autoclaved samples. It was found that QWF contains 53.77% SiO2, while ESP contains 97.8% CaO which are key components for tobermorite synthesis. This study also revealed that the mixture with only 10% cement has the highest compressive strength among the QWF-ESP samples. Furthermore, the formation of tobermorite in the samples was confirmed through XRD analysis. Hence, the hydrothermal curing of QWF –ESP can be further developed to produce functional tobermorite – bearing materials.
Simple Non-linear Numerical Modelling for Unreinforced and Frp-Reinforced Masonry Domes
Authors: Gandolfi Alessandro , Pingaro Natalia , Milani Gabriele
Published: December 2023

This paper presents a new method to model the nonlinear behaviour of masonry double curvature structures, possibly reinforced by composite materials, by means of conventional elasto-plastic analyses. It is meant to be used in professional design, especially for assessment and retrofitting purposes, therefore based on the exploitation of the simplest nonlinear Finite Elements available in a commercial software, namely trusses with elasto-fragile and elasto-ductile behaviour (Cutoff Bars). The numerical static nonlinear analyses are carried out by considering elastic hexahedral elements for bricks and lumping nonlinearities on joints. These have been assumed in turn elastic-brittle and elastic-plastic by using 1D elements, respectively Point Contacts, under No-Tension Material hypothesis, and Cutoff Bars, assigning small tensile resistance to the material. The reinforcement, realised with FRP hooping strips, has been successfully modelled in a similar fashion, i.e. by applying perfectly bonded elastic-plastic Cutoff Bars at the extrados of the dome, where the debonding is accounted for in a conventional way limiting the tensile strength according to Italian Standards indications. The procedure is validated against benchmark models with the same geometry, using experimental data and more refined structural model results for comparison.
Determination of Active Pharmaceutical Ingredients in Saridon Tablets Using an Economical and Sensitive TLC Method Combined with Densitometry
Authors: Pyka-Pająk Alina
Published: December 2023

New TLC-densitometric method have been developed for the identification and quantification of paracetamol (PA), propyphenazone (PP) and caffeine (C) of Saridon tablets using the NP-TLC technique combined with densitometry. This method allows for the simultaneous determination of PA, PP, and C in the same sample. Among all tested chromatographic conditions, the mixture consisting of chloroform + toluene + ethyl acetate + ethanol + acetic acid (18:18:7.5:5.0:0.3, v/v) and silica gel 60F254 plate proved to be the most effective for the separation of three tested active pharmaceutical ingredients (APIs) and substances related to paracetamol. The fully validation of the proposed NP-TLC method proves that it is specific, precise, accurate, robust and sensitive. The percentage content in relation to the content declared by the manufacturer is for propyphenazone 99.8%, paracetamol 101.6% and caffeine 100.8%, which are in accordance with pharmacopoeial requirements. The results presented indicate the possibility of using the developed method in the routine control of pharmaceutical preparations containing these APIs. The proposed method is economical and more sensitive compared to the previously proposed planar methods for the simultaneously determination of PA, PP and CAPIs. Will be an What is more, the presented method may be anaxcellent excellent economical alternative when HPLC method is unavailable for such determination.
Pre-feasibility Study and Design of a Multipurpose Reservoir
Authors: Hiben Mehari Gebreyohannes , Awoke Admasu Gebeyehu
Published: December 2023

In order to achieve the target, several activities are being undertaken, including the development of multipurpose reservoir planning for the water supply and sanitation infrastructure, irrigation, and hydropower development for the H project. To undertake this work, the main data given was rainfall data, flow data, catchment area, base population for water supply, and so on. This report presents a specifically preliminary study and design of water supply, irrigation, and hydropower development for the project, which is carried out in accordance with the scope of work given by our professor. The preliminary study and design are therefore to investigate scenarios and alternatives and prepare a document of water supply, irrigation, and hydropower infrastructures for the provision of the assignment. This report, as required in the assignment, contains project background, water sources assessment, selection of suitable hydropower potential, and irrigation sizing, design criteria, descriptions of the proposed scheme, preliminary design of water supply components. The objective of the project is to recommend and design a cost-effective water supply system, irrigation, and hydropower development to supply reliable, sufficient, and safe water from a defined water source to the H project. The specific objectives of the investigation works are: • To assess potential water source alternatives for water supply • Selecting appropriate size for the reservoir which could satisfy all water demand • Assess and select suitable irrigation development and hydropower potential. • Preliminary study and design of all components of the reservoir and appurtenant structures The scope of the project generally focuses on preliminary study and design of water supply, irrigation and hydropower development components from water sources potential and the water balance output.
Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in Host’s Immunity
Authors: Mondelli Mario U , Ottolini Sabrina , Oliviero Barbara , Mantovani Stefania , Cerino Antonella , Mele Dalila , Varchetta Stefania
Published: December 2023

Hepatitis C virus (HCV) is diffused worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the efficiency of host’s immunity. Attempts have been made to develop an effective vaccine, but efficacy trials have met with failure. The availability of highly efficacious direct acting antivirals (DAA) has shed hopes for progressive elimination of chronic HCV infection; however, this approach requires a global monumental effort. Moreover, DAA treatment does not completely restore the normal immunologic homeostasis. Here we discuss the main immunological features of immune responses to HCV and the epigenetic scars that chronic viral persistence leaves behind.
Title Novel Insights into the Neuroprotective Attributes of Polyamines in Selected Edible and Medicinal Fungi: A Pioneering Report
Authors: Rašeta Milena , Kebert Marko , Mišković Jovana , Rakić Milana , Kostić Saša , Čapelja Eleonora , Karaman Maja
Published: December 2023

The therapeutic effectiveness of current neurodegenerative diseases treatments is still under debate because of problems with bioavailability and a range of side effects. Fungi, which are increasingly recognized as sources of natural antioxidants and AChE enzyme inhibitors, may thus serve as potent neuroprotective agents. Previous studies have associated the anti-AChE and antioxidant activities of fungi mostly with polysaccharides and phenolic compounds, while other secondary metabolites such as polyamines (PAs) have been neglected. This study aimed to investigate eight edible and medicinal fungi from Serbia, marking the initial investigation into the neuroprotective capabilities of Postia caesia, Clitocybe odora, Clitopilus prunulus, and Morchella elata. Neuroprotective activity was examined using Ellman assay, while antioxidant capacity was tested by conducting DPPH, NO, ABTS and FRAP tests. PAs levels were determined by HPLC coupled with fluorescent detection. Ganoderma applanatum and Lepista nuda exhibited the most robust anti-AChE (98.05 ± 0.83% and 99.94 ± 3.10%, respectively) and antioxidant activities attributed to the synergistic effects of total protein, total phenolic and PAs levels. Furthermore, P. caesia displayed significant AChE inhibition (88.21 ± 4.76%), primarily linked to elevated SPD (62.98 ± 3.19%) and PUT levels (55.87 ± 3.16%). Our results highlight the need of thorough research to comprehend the intricate relationships between distinct fungus species and AChE inhibition. However, it's important to recognize that more research is required to identify the precise substances causing the reported inhibitory effects.
Global and Local Enhancement of Low-light Endoscopic Images
Authors: Mou En , Wang Huiqian , Yang Meifang , Cao Enling , Chen Yuanyuan , Ran Chunlan , Pang Yu
Published: December 2023

Endoscopic medical images can suffer from uneven illumination, low contrast, and lack of texture information due to the use of point directional light sources and the presence of narrow tissue structures, posing diagnostic difficulties for physicians. In this paper, a deep learning-based su-pervised illumination enhancement network is designed for low-light endoscopic images, aiming to improve both global illumination and local details. Initially, a global illumination enhancement module is formulated utilizing a higher-order curve function to improve global illumination. Sec-ondly, a local feature extraction module incorporating dual attention is designed to capture local detailed features. Considering the significance of color fidelity in biomedical scenarios, the designed loss function prioritizes introducing color loss to alleviate image color distortion. Compared with seven state-of-the-art enhancement algorithms on Endo4IE endoscopic datasets, experimental re-sults show that the proposed method can better enhance low-light endoscopic images and avoid image color distortion. It provides an efficient method to enhance images captured by endoscopes which can effectively assist clinical diagnosis and treatment.
A Review of Numerical and Physical Methods to Analyze the Coupled Hydro-Aero-Structural Dynamics of Floating Wind Turbine Systems
Authors: Amiri Mojtaba Maali , Shadman Milad , Estefen Segen F.
Published: December 2023

Recently, more wind turbine systems are being installed in deep waters far from the coast. Several concepts of floating wind turbine systems (FWTSs) are developed, among which the semisubmersible platform, due to its applicability in different water depths, good hydrodynamic performance, and facility in the installation process, constitutes the most explored technology compared to the others. However, a significant obstacle to the industrialization of this technology is a design of a cost-effective FWTS, which can be achieved by optimizing the geometry, size and weight of the floating platform, along with the mooring system. This is only possible by selecting a method capable of accurately analyzing the FWTS coupled hydro-aero-structural dynamics at each design stage. Accordingly, this paper aims at providing a detailed overview of the most common coupled numerical and physical methods, including their basic assumptions, formulations, limitations, and costs, used for analyzing the dynamics of FWTSs, mainly those supported by a semisubmersible, to assist the choice of the most suitable method at each design phase of FWTSs. Finally, the article discusses possible future research to address challenges in modeling FWTSs dynamics that persist to date.
Exploring Machine Learning Algorithms-Aid Diagnosis for Chronic Kidney Disease
Authors: García-González Omar , Villalon-Turrubiates Ivan E. , Chávez-Camarena Luis E , Hernández-Mejía Carlos
Published: December 2023

Chronic Kidney Disease is a medical condition that causes the decrease in the kidney function and can eventually derive in a total cessation of the work of the organ. It currently affects >10% of the global population, and the number is expected to grow within the next few years, since the correlated diabetes condition is escalating too. Diagnosing the disease on its early stages is crucial to improve life quality, and to increase the chances of survival. The traditional diagnostic methods, which include a biopsy, are invasive, expensive and dangerous. With the use of machine learning algorithms like neural networks, random forest and genetic algorithms, this paper seeks to discover an algorithm with high accuracy, whose selected attributes will be the most optimal combination aiming to reduce the cost, level of invasiveness, and easiness to obtain.
Smart Conditioning with Venetoclax Enhanced Sequential FLAMSA + RIC in Patients with High-Risk Myeloid Malignancies
Authors: Schulz Felicitas , Jäger Paul Sebastian , Tischer Johanna , Fraccaroli Alessia , Bug Gesine , Hausmann Andreas , Baermann Ben Niklas , Tressin Patrick , Hoelscher Alexander Sebastian , Kasprzak Annika , Nachtkamp Kathrin , Schetelig Johannes , Hilgendorf Inken , Germing Ulrich , Dietrich Sascha , Kobbe Guido
Published: December 2023

Up to 50% of patients with high-risk myeloid malignancies die of relapse after allogeneic stem cell transplantation. Current sequential conditioning regimens like the FLAMSA protocol combine intensive induction therapy with TBI or alkylators. Venetoclax has synergistic effects to chemotherapy. In a retrospective survey among German transplant centers, we identified 61 patients with myeloid malignancies that had received FLAMSA based sequential conditioning with Venetoclax between 2018 and 2022 as an individualized treatment approach. Sixty patients (98%) had active disease at transplant and 74% had genetic high-risk features. Patients received allografts from matched unrelated, matched related or mismatched donors. Tumor lysis syndrome occurred in two patients but no significant non-hematologic toxicity related to Venetoclax was observed. At day +30, 55 patients (90%) were in complete remission. Acute GvHD II°-IV° occurred in 17 (28%) and moderate/severe chronic GvHD in 7 patients (12%). Event-free survival and overall survival were 64% and 80% at 1 year as well as 57% and 75% at 2 years, respectively. The combination of sequential FLAMSA-RIC with Venetoclax appears to be safe and highly effective. To further validate these insights and enhance the idea of smart conditioning, a controlled prospective clinical trial has been initiated in 07/2023.
Advancements in Bariatric Surgery: A Comparative Review of Laparoscopic and Robotic Techniques
Authors: Velardi Angelo Maria , Anoldo Pietro , Nigro Stefania , Navarra Giuseppe
Published: December 2023

This article examines the evolution of bariatric surgery, with a focus on emerging technologies such as robotics and laparoscopy. In the case of gastric bypass, no significant differences have emerged between the two techniques in terms of hospitalization duration, weight loss, weight regain, or 30-day mortality. Robotic surgery, while requiring more time in the operating room, has been associated with lower rates of bleeding, mortality, transfusions, and infections. In revisional bariatric surgery, the robotic approach has shown fewer complications, shorter hospital stays, and a reduced need for conversion to open surgery. In the case of sleeve gastrectomy, robotic procedures have required more time and longer post-operative stays but have recorded lower rates of transfusions and bleeding compared to laparoscopy. However, robotic surgeries have proven to be more costly and potentially more complex in terms of post-operative complications. The review has also addressed the topic of the single anastomosis duodeno-ileal switch (SADIS), finding comparable results between robotic and laparoscopic techniques, although robotic procedures have required more time in the operating room. Robotic technology has proven to be safe and effective, albeit with slightly longer operating times in some cases.
Shelf-Life Study of Probiotic Dahi Prepared by a New Isolated Probiotic, Lactobacillus acidophilus Strain JB2CON
Authors: Mujahidy Jakaria , Uddin Md. Ekhlas , Rahman Shahidur , Mamun-Or-Rashid A. N. M.
Published: December 2023

The principal goal of this current study was to isolate a new potential probiotic strain to prepare contamination-free probiotic dahi in a dosage form with desired shelf life. To achieve our target, firstly, probiotic dahi was prepared by a probiotic strain, Lactobacillus acidophilus JB2CON (OM909067) (identified by 16S sequencing) isolated from natural dahi in Dhaka, Bangladesh. The isolate showed five probiotic features by in vitro test and had an antagonistic effect against five different pathogens. More interestingly, it inhibited Escherichia coli (diameter of zone of inhibition = 15.75±0.35) the most. In the time-kill analysis method, E. coli was killed totally within 5.50 hours of fermentation. Finally, the time duration of 14 days was an ideal shelf life, because the probiotic count increased but a slight change in pH did not affect the taste (sourness/acidity) of dahi. The most significant impact of this research is that the probiotic dahi of our experiment might be used as a cheap option for preventing pathogenic Escherichia coli-related foodborne diseases worldwide, especially in underdeveloped countries like Bangladesh.
Enhancing THD Reduction in a 10kW DC-AC Inverter through Non-linear Control: A Fuzzy-PI Approach with Anti-Windup and Passive Filtering
Authors: Rodríguez-Flores Jesús , Herrera-Perez Victor , Pacheco-Cunduri Mayra , Medina-Sánchez Martin , Hernandez-Ambato Jorge
Published: December 2023

This paper presents the mathematical modeling for designing a 10[kW] DC-AC inverter system from 48 [V] DC to 120 V ACrms, considering its non-linear operation, allowing to obtain a detailed simulation to assess the proposed fuzzy PI control (with anti-windup action) and its optimal operation. The performance assessment of the converter was carried out with the discrete treatment of the voltage and current signals using spectral analysis, filtering considerations, and evaluation of limit cycle technique to determine the system's stability. The main results showed that THD at the filter output (transformer and capacitor) was around 0.0322% and 0.0632% at nominal load in open loop and closed loop, respectively. The inverter system presented more sensitivity in the current signal with a ripple at 120 [Hz] of 2.02% and at 5000 [Hz] of 10.62% (at nominal load). However, when the system operates in a closed loop, the current ripple at 120 [Hz] is 2.38% and at 5000 [Hz] is 10.62%.
Proguanil Suppresses Breast Tumor Growth In Vitro and In Vivo through Mitochondrial Dysfunction
Authors: Gupta Nehal , Curcic Marina , Srivastava Sanjay K.
Published: December 2023

Breast cancer is a serious disease and the second leading cause of cancer-related death among women in the U.S. New treatments for this aggressive disease are urgently needed. Repurposing FDA-approved drugs for cancer treatment is an alternative that saves time and lowers the costs needed for drug development. In this study, we investigated the effects of proguanil, an anti-malarial drug, in breast cancer cells. Proguanil exhibited a significant cytotoxic effect on breast cancer cell lines including patient derived cell lines. Proguanil caused apoptosis through increased production of ROS and consequent decrease of mitochondrial membrane potential, mitochondrial respiration, and ATP production rates. ROS generation by proguanil was up to 3-fold higher when compared to the control. Proguanil treatment increased the expression of Bax, p-H2AX, cleaved-caspase 9, cleaved PARP, and down-regulated bcl-2 and survivin in breast cancer cell lines. The enlargement of 4T1 breast tumors in female Balb/c mice was suppressed by 55% through daily oral administration of 20mg/kg of proguanil. Western blot analyses of proguanil- treated tumors showed increased levels of p-H2AX, Bax, c-PARP, and c-caspase3 compared to control. Proguanil proved to be an efficient in vitro and in-vivo inhibitor of breast cancer cells, hence should be considered further for clinical investigation against breast cancer.