bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Pangean evolution of central southern Laurentia: Insights from zircon U/Pb geochronology, Marathon-Solitario fold-and-thrust belt, west Texas
Authors: Dickerson* Patricia W. , Hall Blaine R. , Stockli Daniel F. , Stockli Lisa D. , Hanson Richard E. , Fanning C. Mark , O'Sullivan Paul
Published: September 2022

Upper Cambrian through Middle Ordovician sedimentary strata of the Marathon/Solitario Basin (west Texas), which were folded and thrust-faulted during late Paleozoic Appalachian-Ouachita orogenesis, preserve evidence of the pre-Pangean history of the central southern Laurentian margin. New detrital zircon analyses reported here are from three Marathon Basin/Solitario formations: the upper Cambrian Dagger Flat Sandstone; the Lower Ordovician Marathon Formation, including the Rodrigues Tank Sandstone Member; and the Middle Ordovician Ft. Peña Formation. The far-southwestern outcrops of those Iapetus margin strata are within the Solitario dome (Presidio and Brewster Counties, Texas).

Solitario zircon U/Pb geochronological results (laser ablation–inductively coupled plasma–mass spectrometry [LA-ICP-MS], sensitive high-resolution ion microprobe [SHRIMP]) expand the record of Cryogenian rifting as the Cuyania terrane separated from Laurentia. We evaluated these new data along with earlier geochronological and geochemical results from rift-related lava clasts in Lower–Middle Ordovician sedimentary subaqueous debris-flow deposits in the northwestern Marathon Basin. Deepening of the Iapetus seaway near the Laurentian margin (late Cambrian–Middle Ordovician) stimulated headward erosion of drainages, reflected in the systematic north-northwestward shift in zircon provenance from the west Texas Grenvillian and Southern Granite-Rhyolite Provinces to Yavapai-Mazatzal and Cheyenne Belt sources.

The Cuyania rifted terrane underwent subduction at the western Gondwanan margin of the Iapetus Ocean in mid-Ordovician time (486 ± 7 Ma to 463 ± 4 Ma), and the resulting volcanism in the Famatina complex (Argentina) was most intense from ca. 472 to 468 Ma. Magmatic zircons from Ft. Peña bentonitic layers have identical U/Pb (488–468 Ma) and biostratigraphic (Darriwilian) ages to those from Famatinian bentonites at Talacasto (470 ± 5 Ma) in the Precordillera of Cuyania. Geologically constrained paleomagnetic reconstructions for 470 Ma depict the proximity of the Famatina arc, the rifted Cuyania terrane, and southern Laurentia at low southern latitudes (equator to ~30°S). These first U/Pb geochronological data from the Marathon/Solitario depocenter of western Iapetus appear to be compatible with such a configuration and can serve as test data for emerging tectonic interpretations.
Supplemental Material: Topographic development of a compressional mountain range, the western Transverse Ranges of California, USA, resulted from localized uplift along individual structures and regional uplift from deeper shortening
Authors: Onderdonk N. , al. et
Published: September 2022

Contains PDF and radial plots of luminescence data (Item A), log-log plots of cumulative incision vs age for fluvial terraces (Item B), and profiles of terrace surfaces displaced by faults 
Progressive loss of the thyroid tissue integrity visualised by serial CT scans
Authors: Koyama Hiroyuki , Hattori Rei , Sagawa Hiroyuki , Tanaka Tomohiro
Published: September 2022

A man in his 70s developed thyrotoxicosis due to painless thyroiditis after starting nivolumab, which was subsequently followed by severe hypothyroidism. We diagnosed him as chronic thyroiditis, initiated levothyroxine supplementation and treated appropriately. Retrospective CT images of the thyroid gland during the clinical course revealed that the CT attenuation value was high at first but gradually decreased. The high-density signal of the normal thyroid tissues reflects its function of concentrating inorganic iodine, and the progressive decrease of the CT density in the present case can be viewed as a reflection of the thyroid destruction and progressive loss of iodine during the clinical course of the development of chronic thyroiditis. Considering the high incidence rate of functional thyroid disease in patients treated with immune checkpoint inhibitors, CT density of the thyroid gland needs to be paid attention to as the first sign of thyroiditis in this patient population.
Cost-effectiveness and return-on-investment of C-reactive protein point-of-care testing in comparison with usual care to reduce antibiotic prescribing for lower respiratory tract infections in nursing homes: a cluster randomised trial
Authors: Boere Tjarda M , El Alili Mohamed , van Buul Laura W , Hopstaken Rogier M , Verheij Theo J M , Hertogh Cees M P M , van Tulder Maurits W , Bosmans Judith E
Published: September 2022

Objectives

C-reactive protein point-of-care testing (CRP POCT) is a promising diagnostic tool to guide antibiotic prescribing for lower respiratory tract infections (LRTI) in nursing home residents. This study aimed to evaluate cost-effectiveness and return-on-investment (ROI) of CRP POCT compared with usual care for nursing home residents with suspected LRTI from a healthcare perspective.

Design

Economic evaluation alongside a cluster randomised, controlled trial.

Setting

11 Dutch nursing homes.

Participants

241 nursing home residents with a newly suspected LRTI.

Intervention

Nursing home access to CRP POCT (POCT-guided care) was compared with usual care without CRP POCT (usual care).

Main outcome measures

The primary outcome measure for the cost-effectiveness analysis was antibiotic prescribing at initial consultation, and the secondary outcome was full recovery at 3 weeks. ROI analyses included intervention costs, and benefits related to antibiotic prescribing. Three ROI metrics were calculated: Net Benefits, Benefit-Cost-Ratio and Return-On-Investment.

Results

In POCT-guided care, total costs were on average €32 higher per patient, the proportion of avoided antibiotic prescribing was higher (0.47 vs 0.18; 0.30, 95% CI 0.17 to 0.42) and the proportion of fully recovered patients statistically non-significantly lower (0.86 vs 0.91; −0.05, 95% CI −0.14 to 0.05) compared with usual care. On average, an avoided antibiotic prescription was associated with an investment of €137 in POCT-guided care compared with usual care. Sensitivity analyses showed that results were relatively robust. Taking the ROI metrics together, the probability of financial return was 0.65.

Conclusion

POCT-guided care effectively reduces antibiotic prescribing compared with usual care without significant effects on recovery rates, but requires an investment. Future studies should take into account potential beneficial effects of POCT-guided care on costs and health outcomes related to antibiotic resistance.

Trial registration number

NL5054.
Does COVID-19 have an impact on influenza vaccine knowledge, attitude and practice among medical students: a 2-year prospective cohort study
Authors: Wang Yunlong , Wu Guangjie , Jiang Yueming , Zou Fa , Gan Lin , Luo Qinwen , Wu Xiaorong , Tang Xiaojun
Published: September 2022

Objectives

To explore the main factors affecting the knowledge, attitude and practice about influenza and influenza vaccine as well as the intention to receive influenza vaccination among the same group of medical students before (2019) and after (2021) the COVID-19 outbreak.

Design

A population-based prospective cohort study.

Setting

A longitudinal cohort study of a selected medical school in Chongqing, China, which ran from 2019 to 2021.

Participants

A total of 803 medical students participated in the study in 2019 and only 484 students responded in 2021. The response rate for our survey was only 60.27% due to graduation, emails being abandoned, etc.

Results

The influenza vaccination rate of students at this medical school was 6.7% in 2019, compared with 25.8% in 2021. The awareness rate of medical students about influenza and influenza vaccine was 82.8% in 2019 and 86% in 2021, and there was no significantly statistical difference between the 2 years (p=0.134); the number of medical students with supportive attitude towards influenza vaccine was 95.1% in 2019 and 97.1% in 2021, and there was no statistically significant difference between the 2 years (p=0.078); the number of students who actively learnt about knowledge related to influenza vaccine rose from 183 (22.8%) in 2019 to 195 (40.3%) in 2021.

Conclusions

The COVID-19 outbreak prompted an increase in influenza vaccination rates among medical students in Chongqing, with almost all students (96.0%) believing that the spread of COVID-19 promoted their knowledge about influenza and influenza vaccine, and the vast majority (74.8%) believing that the spread of COVID-19 promoted their willingness to receive influenza vaccine.
ACTonDiabetes: study protocol of a pragmatic randomised controlled trial for the evaluation of an acceptance and commitment-based internet-based and mobile-based intervention for adults living with type 1 or type 2 diabetes
Authors: Bendig Eileen , Schmitt Andreas , Wittenberg Amelie , Kulzer Bernhard , Hermanns Norbert , Moshagen Morten , Baumeister Harald
Published: September 2022

Introduction

Living with diabetes can be burdensome and lead to serious emotional distress and impaired mental health. Acceptance and commitment therapy (ACT) can support people facing the challenges of living with diabetes. This trial aims to evaluate the effectiveness and cost-effectiveness of the internet-based and mobile-based intervention (IMI) ‘ACTonDiabetes’ in reducing diabetes distress against enhanced treatment as usual (TAU+) following specialised diabetes care.

Methods and analysis

A two-armed pragmatic randomised controlled trial will be conducted to evaluate the guided IMI ACTonDiabetes against TAU+. A total of 210 adults with type 1 or type 2 diabetes and elevated diabetes distress (Problem Areas in Diabetes ≥40) will be recruited at a specialised diabetes centre. The intervention begins 2–4 weeks after hospital discharge and takes about 7–10 weeks to complete. Assessments are performed at baseline and 5 and 10 weeks as well as 6 and 12 months after randomisation. The primary outcome is diabetes distress at a 10-week follow-up (T2). Secondary outcomes are depression (Patient Health Questionnaire-8), psychological well-being (WHO-5), quality of life (Assessment of Quality of Life-8 Dimension), Diabetes-related Self-Management Questionnaire, diabetes acceptance (Acceptance and Action Diabetes Questionnaire) and negative treatment effects (Inventory for the Assessment of Negative Effects of Psychotherapy). All statistical analyses will be performed based on the intention-to-treat principle with additional per-protocol analyses. Changes in outcomes will be evaluated using the general linear model. A health-economic evaluation will be conducted from a societal perspective. Reasons for drop-out will be systematically investigated.

Ethics and dissemination

This clinical trial has been approved by the State Medical Chamber of Baden-Württemberg (file no. B-F-2019-010). Trial results will be submitted for publication in a peer-reviewed journal and presented at conferences.

Trial registration number

DRKS00016738.
MiCare study, an evaluation of structured, multidisciplinary and personalised post-ICU care on physical and psychological functioning, and quality of life of former ICU patients: a study protocol of a stepped-wedge cluster randomised controlled trial
Authors: van Sleeuwen Dries , van de Laar Floris A , Simons Koen , van Bommel Daniëlle , Burgers-Bonthuis Dominique , Koeter Julia , Bisschops Laurens L A , Vloet Lilian , Brackel Marianne , Teerenstra Steven , Adang Eddy , van der Hoeven Johannes G , Zegers Marieke , van den Boogaard Mark
Published: September 2022

Introduction

Over 70% of the intensive care unit (ICU) survivors suffer from long-lasting physical, mental and cognitive problems after hospital discharge. Post-ICU care is recommended by international guidelines, but evidence for cost-effectiveness lacks. The aim of this study is to evaluate the clinical effectiveness and cost-effectiveness of structured, multidisciplinary and personalised post-ICU care versus usual care on physical and psychological functioning and health-related quality of life (HRQoL) of ICU survivors, 1- and 2-year post-ICU discharge.

Methods and analysis

The MONITOR-IC post-ICU care study (MiCare study) is a multicentre stepped-wedge randomised controlled trial conducted in five hospitals. Adult patients at high risk for critical illness-associated morbidity post-ICU will be selected and receive post-ICU care, including an invitation to the post-ICU clinic 3 months after ICU discharge. A personalised long-term recovery plan tailored to patients’ reported outcome measures will be made. 770 (intervention) and 1480 (control) patients will be included. Outcomes are 1- and 2-year HRQoL (EuroQol Instrument (EQ-5D-5L)), physical (fatigue and new physical problems), mental (anxiety, depression and post-traumatic stress disorder), and cognitive symptoms and cost-effectiveness. Medical data will be retrieved from patient records and cost data from health insurance companies.

Ethics and dissemination

Due to the lack of evidence, Dutch healthcare insurers do not reimburse post-ICU care. Therefore, evaluation of cost-effectiveness and integration in guidelines supports the evidence. Participation of several societies for physicians, nurses, paramedics, and patients and relatives in the project team increases the support for implementation of the intervention in clinical practice. Patients and relatives will be informed by the patient associations, hospitals and professional associations. Informing healthcare insurers about this project’s results is important for the consideration for inclusion of post-ICU care in Dutch standard health insurance. The study is approved by the Radboud University Medical Centre research ethics committee (2021-13125).

Trial registration number

NCT05066984.
Incidence and prevalence of type 1 diabetes in Africa: a systematic review and meta-analysis protocol
Authors: Katte Jean Claude , Agoons Batakeh B , Akem Dimala Christian , Bigna Jean Joel , Sobngwi Eugene
Published: September 2022

Introduction

Type 1 diabetes is reported to have significant mortality in Africa. However, there is a paucity of data on pooled estimates of its incidence and prevalence in Africa. This first systematic review and meta-analysis will be conducted to determine the incidence and prevalence of this condition in Africa.

Methods

Based on predefined criteria, electronic databases, including PubMed, Excerpta Medica database, Africa Journal Online and Web of Science, will be searched for relevant studies involving paediatric and adult patients, with no language restrictions. Quality assessment of the individual studies will be performed, and the Q-statistic test and I2 statistic test will be used to assess statistical heterogeneity. Appropriate meta-analysis will then be used to pool studies judged to be clinically homogenous. Egger’s test will be used to detect publication bias. The planned search dates for the eligible articles are from 1 September to 30 September 2022.

Ethics and dissemination

Since this review will use previously published studies, it will not require the consent of an ethics committee. The results will be prepared and disseminated through a peer-reviewed journal and will be presented in relevant conferences.

PROSPERO registration number

CRD42021278227.
Grand rounds in methodology: four critical decision points in statistical process control evaluations of quality improvement initiatives
Authors: Marang-van de Mheen Perla J , Woodcock Thomas
Published: September 2022

Quality improvement (QI) projects often employ statistical process control (SPC) charts to monitor process or outcome measures as part of ongoing feedback, to inform successive Plan-Do-Study-Act cycles and refine the intervention (formative evaluation). SPC charts can also be used to draw inferences on effectiveness and generalisability of improvement efforts (summative evaluation), but only if appropriately designed and meeting specific methodological requirements for generalisability. Inadequate design decreases the validity of results, which not only reduces the chance of publication but could also result in patient harm and wasted resources if incorrect conclusions are drawn. This paper aims to bring together much of what has been written in various tutorials, to suggest a process for using SPC in QI projects. We highlight four critical decision points that are often missed, how these are inter-related and how they affect the inferences that can be drawn regarding effectiveness of the intervention: (1) the need for a stable baseline to enable drawing inferences on effectiveness; (2) choice of outcome measures to assess effectiveness, safety and intervention fidelity; (3) design features to improve the quality of QI projects; (4) choice of SPC analysis aligned with the type of outcome, and reporting on the potential influence of other interventions or secular trends.

These decision points should be explicitly reported for readers to interpret and judge the results, and can be seen as supplementing the Standards for Quality Improvement Reporting Excellence guidelines. Thinking in advance about both formative and summative evaluation will inform more deliberate choices and strengthen the evidence produced by QI projects.
Prevalence of ankle instability in performers of Chinese classical dance: a cross-sectional study of 105 Chinese dancers
Authors: Chui Vivian Wai-Ting , Tong Anson Hei-Ka , Hui Jasmine Yat-Ning , Yu Heidi Hiu-Tung , Yung Patrick Shu-Hang , Ling Samuel Ka-Kin
Published: September 2022

Objectives

Foot and ankle injuries are commonly seen in dancers, yet limited studies exist on the injury prevalence of performers of Chinese classical dance. This study aims to determine and assess the prevalence of chronic ankle instability (CAI) in Chinese dancers and correlate the impact of CAI with foot function.

Methods

This is a cross-sectional study of 105 Chinese dancers. CAI was assessed using the Cumberland Ankle Instability Tool and foot function via the Foot and Ankle Outcome Score (FAOS). Both self-reported assessment tools were distributed online between January and February 2021. Subjects were divided into CAI and healthy groups to observe any correlations in demographics, training hours and foot function.

Results

CAI was seen in 28% of Chinese dancers, with most being unilateral instability. The number of training hours, level of expertise, occupation, gender and age showed no statistical significance with CAI. The FAOS showed that subjects with CAI had significantly greater pain and poorer quality of life.

Discussion and conclusion

CAI is a problem affecting 28% of performers of Chinese dance. Future research should investigate the ankle biomechanics in Chinese dance and specific risk factors for CAI to formulate strategies to prevent ankle injuries in Chinese dancers.
Biopsy and blood-based molecular biomarker of inflammation in IBD
Authors: Argmann Carmen , Hou Ruixue , Ungaro Ryan C , Irizar Haritz , Al-Taie Zainab , Huang Ruiqi , Kosoy Roman , Venkat Swati , Song Won-Min , Di'Narzo Antonio F , Losic Bojan , Hao Ke , Peters Lauren , Comella Phillip H , Wei Gabrielle , Atreja Ashish , Mahajan Milind , Iuga Alina , Desai Prerak T , Branigan Patrick , Stojmirovic Aleksandar , Perrigoue Jacqueline , Brodmerkel Carrie , Curran Mark , Friedman Joshua R , Hart Amy , Lamousé-Smith Esi , Wehkamp Jan , Mehandru Saurabh , Schadt Eric E , Sands Bruce E , Dubinsky Marla C , Colombel Jean-Frederic , Kasarskis Andrew , Suárez-Fariñas Mayte
Published: September 2022

Objective

IBD therapies and treatments are evolving to deeper levels of remission. Molecular measures of disease may augment current endpoints including the potential for less invasive assessments.

Design

Transcriptome analysis on 712 endoscopically defined inflamed (Inf) and 1778 non-inflamed (Non-Inf) intestinal biopsies (n=498 Crohn’s disease, n=421 UC and 243 controls) in the Mount Sinai Crohn’s and Colitis Registry were used to identify genes differentially expressed between Inf and Non-Inf biopsies and to generate a molecular inflammation score (bMIS) via gene set variance analysis. A circulating MIS (cirMIS) score, reflecting intestinal molecular inflammation, was generated using blood transcriptome data. bMIS/cirMIS was validated as indicators of intestinal inflammation in four independent IBD cohorts.

Results

bMIS/cirMIS was strongly associated with clinical, endoscopic and histological disease activity indices. Patients with the same histologic score of inflammation had variable bMIS scores, indicating that bMIS describes a deeper range of inflammation. In available clinical trial data sets, both scores were responsive to IBD treatment. Despite similar baseline endoscopic and histologic activity, UC patients with lower baseline bMIS levels were more likely treatment responders compared with those with higher levels. Finally, among patients with UC in endoscopic and histologic remission, those with lower bMIS levels were less likely to have a disease flare over time.

Conclusion

Transcriptionally based scores provide an alternative objective and deeper quantification of intestinal inflammation, which could augment current clinical assessments used for disease monitoring and have potential for predicting therapeutic response and patients at higher risk of disease flares.
Impact of the COVID-19 pandemic on work productivity in patients with spondyloarthritis: results from the Dutch SpA-Net registry
Authors: Webers Casper , van Tubergen Astrid , Vonkeman Harald E , Boonen Annelies
Published: September 2022

Objective

To investigate whether work productivity in patients with spondyloarthritis (SpA) changed following the onset of the COVID-19 pandemic.

Methods

Data from the Dutch SpA-Net registry were used. Work productivity was assessed with the Work Productivity and Activity Impairment General Health questionnaire. Proportions of patients employed and their overall work impairment (0%–100%) were compared during a 1-year period before (‘pre-pandemic’) and a 1-year period after the onset (‘post-onset’) of the pandemic (March 2020). Generalised estimating equation analysis of all assessments since 2016 explored whether overall work impairment (absenteeism and presenteeism) in employed patients changed with pandemic onset, adjusting for confounders. Similar analyses with disease activity as outcome were used to facilitate interpretation of work productivity results.

Results

Data were available during pre-pandemic and post-onset years for 204 patients. Pre-pandemic, 128 (62%) patients were employed. Post-onset, 7 (3.4%) had lost employment, while another 7 (3.4%) originally unemployed gained employment. Overall work impairment was worse following pandemic onset (37.0%) compared with pre-pandemic (27.0%) (p<0.01). Post-onset increase in overall work impairment was mainly observed in patients with lower education (B=9.57, 95% CI 5.63 to 13.51) and largely attributable to absenteeism (B=11.15, 95% CI 7.44 to 14.86). In patients with high education, no such increase was seen. Disease activity did not change with pandemic onset.

Conclusions

Work productivity worsened in patients with SpA after pandemic onset, especially in patients with lower education, while employment losses were limited and disease activity remained stable. Work support should be considered during the COVID-19 pandemic and thereafter for those vulnerable to adverse work outcome.
Circulating endothelial microvesicles and their carried miR-125a-5p: potential biomarkers for ischaemic stroke
Authors: Ma Xiaotang , Liao Xiaorong , Liu Jiehong , Wang Yan , Wang Xiang , Chen Yanfang , Yin Xiaojian , Pan Qunwen
Published: September 2022

Background

Endothelial microvesicles (EMVs) are closely associated with the status of endothelial cells (ECs). Our earlier study has shown that EMVs could exert protective roles in ECs by transferring their carried miR-125a-5p. However, whether circulating EMVs and their carried miR-125a-5p can be used as biomarkers in ischaemic stroke (IS) are remain unknown.

Methods

We recruited 72 subjects with IS, 60 subjects with high stroke risk and 56 age-matched controls. The circulating EMVs and their carried miR-125a-5p (EMV-miR-125a-5p) levels were detected. We used microRNA (miR) array to study expression changes of miRs in plasma EMVs samples of three IS patients and three matched healthy controls. Transient middle cerebral artery occlusion (tMCAO) was used to establish IS mouse model.

Results

EMVs level was obviously elevated in IS patients, with the highest level in acute stage, and was positively related to carotid plaque, carotid intima–media thickness (IMT), National Institutes of Health Stroke Scale (NIHSS), infarct volume. On the contrary, we observed that EMV-miR-125a-5p level was obviously reduced in IS, with the lowest level in acute stage, and was negatively correlated with carotid plaque, IMT, NIHSS scores, infarct volume. EMVs and EMV-miR-125a-5p levels were closely related with large artery atherosclerosis subgroup. Importantly, EMVs and EMV-miR-125a-5p levels could serve as independent risk factors, and receiver operating characteristic curve achieved an area under curve (AUC) of 0.720 and 0.832 for IS, respectively, and elevated to 0.881 after their combination. In IS mouse model, control EMVs or n-EMVs administration could decrease the infarct volume and neurological deficit score, while increase the cerebral blood flow of IS mice compared with vehicle group, while IS EMVs or oxygen and glucose deprivation (OGD)-EMVs administration aggravated the tMCAO induced ischaemic injury. In addition, we observed that OGD EMVmiR-125a-5pcould partially ameliorate the OGD EMVs induced brain injury after IS.

Conclusions

These findings demonstrate that circulating EMVs and EMV-miR-125a-5p are closely related with the occurrence, progress, subtypes and severity of IS, and they can serve as innovative biomarkers and therapeutic targets for IS, especially when they are combined.
Overland and Oversea: Domestic Trade Frictions in the Philippines
Authors: GO EUGENIA
Published: September 2022

Domestic trade costs are anecdotally high in the Philippines, and yet a systematic and spatially comparable metric of trade costs is unavailable. This paper fills this gap by estimating province border effects, or a province’s tendency to trade with itself rather than with other provinces. Subsequently, the effects of a maritime transport program based on roll-on roll-off (RORO) ships on province border effects are assessed. Using two novel datasets—the starting dates of RORO shipping services by route, and the intraprovince trade of agricultural products—this study finds that province border effects are substantial, with a typical province trading 51 times more with itself than with other provinces. The RORO transport program is associated with an average reduction of 35% of this home province bias. However, the border effect reductions are unevenly distributed, with the largest reductions concentrated in provinces near the biggest demand centers.
THE PIVOTAL ROLE OF TOP MANAGEMENT IN FOSTERING INBOUND OPEN INNOVATION IN SMEs: THE MEDIATION EFFECT OF ORGANISATIONAL CHANGE
Authors: CHABBOUH HAJER , BOUJELBÈNE YOUNÈS
Published: September 2022

This study aims to investigate the pivotal role of top management and organizational change in explaining the degree of openness of SMEs to inbound open innovation practices. To do this, a conceptual model has been proposed and tested from a sample of 186 SMEs operating in Tunisian manufacturing industry. The examination of this model based on the Structural Equation Modeling confirms that entrepreneurial strategic vision of the top management favorably influences the degree of openness in SMEs. Moreover, the results obtained showed that organizational change associated with cultural aspects is an important determinant in the introduction of inbound openness practices, while that related to the organizational structure seems to be insignificant. Based on these findings, this research paper contributes to the enrichment of knowledge on inbound open innovation in SMEs and produces some managerial implications that can be suggested to stimulate the success of the openness approach according to the Open innovation paradigm.
The Evolution of HCI and Human Factors: Integrating Human and Artificial Intelligence
Authors: Chignell Mark , Wang Lu , Zare Atefeh , Li Jamy
Published: September 2022

We review HCI history from both the perspective of its 1980s split with human factors and its nature as a discipline. We then revisit human augmentation as an alternative to user friendliness that seems particularly relevant in the areas of inclusive design and artificial intelligence. Viewing human-AI interaction as a kind of human augmentation raises issues such as how to promote trust and situation awareness. We also pose the question: Can HCI and human factors engineering work together to solve the increasingly urgent challenges of human-AI technology? In an initial look at this question, we contrast the different approaches of HCI and human factors on emerging AI research. This article concludes by considering other potentially promising paths for HCI. We propose more collaboration between HCI and human factors, or related disciplines, in the future to address the massive challenges posed by the rapid growth in data science and artificial intelligence.
SLR: From Saltzer and Schroeder to 2021…47 Years of Research on the Development and Validation of Security API Recommendations
Authors: Patnaik Nikhil , Dwyer Andrew , Hallett Joseph , Rashid Awais
Published: September 2022

Producing secure software is challenging. The poor usability of security Application Programming Interfaces (APIs) makes this even harder. Many recommendations have been proposed to support developers by improving the usability of cryptography libraries—rooted in wider
best practice
guidance in software engineering and API design. In this SLR, we systematize knowledge regarding these recommendations. We identify and analyze 65 papers, offering 883 recommendations. Through thematic analysis, we identify seven core ways to improve usability of APIs. Most of the recommendations focus on helping API developers to
construct
and
structure
their code and make it more usable and easier for programmers to
understand
. There is less focus, however, on
documentation
,
writing requirements
,
code quality assessment
, and the impact of
organizational software development practices
. By tracing and analyzing paper ancestry, we map how this knowledge becomes validated and translated over time. We find that very few API usability recommendations are empirically validated, and that recommendations specific to usable security APIs lag even further behind.
Security Best Practices: A Critical Analysis Using IoT as a Case Study
Authors: Barrera David , Bellman Christopher , Van Oorschot Paul
Published: September 2022

Academic research has highlighted the failure of many
Internet of Things (IoT)
product manufacturers to follow accepted practices, while IoT security
best practices
have recently attracted considerable attention worldwide from industry and governments. Given current examples of security advice, confusion is evident from guidelines that conflate desired outcomes with security practices to achieve those outcomes. We explore a surprising lack of clarity, and void in the literature, on what (generically)
best practice
means, independent of identifying specific individual practices or highlighting failure to follow best practices. We consider categories of security advice, and analyze how they apply over the lifecycle of IoT devices. For concreteness in discussion, we use iterative inductive coding to code and systematically analyze a set of 1,013 IoT security best practices, recommendations, and guidelines collated from industrial, government, and academic sources. Among our findings, of all analyzed items, 68% fail to meet our definition of an (actionable) practice, and 73% of all actionable advice relates to the software development lifecycle phase, highlighting the critical position of manufacturers and developers. We hope that our work provides a basis for the community to better understand best practices, identify and reach consensus on specific practices, and find ways to motivate relevant stakeholders to follow them.
Exceptionally Lethal: American Police Killings in a Comparative Perspective
Authors: Hirschfield Paul J.
Published: September 2022

Police in the United States stand out in the developed world for their reliance on deadly force. Other nations in the Americas, however, feature higher or similar levels of fatal police violence (FPV). Cross-national comparative analyses can help identify stable and malleable factors that distinguish high-FPV from low-FPV countries. Two factors that clearly stand out among high-FPV nations are elevated rates of gun violence—which fosters a preoccupation with danger and wide latitude to use preemptive force—and ethnoracial inequality and discord. The latter seems to be tied to another fundamental difference between the United States and most other developed nations—the “radically decentralized structure of U.S. policing” ( Bayley & Stenning 2016 ). Hyperlocalism limits the influence of external oversight, along with expertise and resources for effective training, policy implementation, and accountability. However, elevated rates of FPV among some Latin American countries with relatively centralized policing demonstrate that decentralization is not a necessary condition for high FPV. Likewise, relatively low FPV in Spain and Chile suggests that achieving low FPV is also possible without the extensive resources and training that appear to suppress FPV in wealthy Northern European nations.
Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1
Authors: Hafen Paul S. , Law Andrew S. , Matias Catalina , Miller Spencer G. , Brault Jeffrey J.
Published: September 2022

AMP deaminase 1 (AMPD1) deficiency has been associated with premature muscle fatigue and reduced work capacity, but this finding has been inconsistent. Herein, we report that although AMPD1 knockdown in mouse skeletal muscle does not change maximal isometric force, it negatively impacts muscle function by slowing contraction and relaxation kinetics in EDL muscle but not SOL muscle. Furthermore, AMPD1 knockdown differentially affects the [AMP]/AMPK responses to fatiguing contractions in an intensity-dependent manner in EDL muscle.
The detection and sensory perception of inspiratory resistive loads in people with chronic tetraplegia
Authors: Luu Billy L. , Lewis R. H Chaminda , Gandevia Simon C. , Boswell-Ruys Claire L. , Butler Jane E.
Published: September 2022

Sensations of breathing are thought to be impaired following chronic tetraplegia. The detection threshold for an added resistive load during inspiration was higher in people with tetraplegia than in healthy able-bodied participants. However, for inspiratory loads above the detection threshold, the perceived magnitude of a resistive load as a function of the peak inspiratory pressure was greater in tetraplegia. Load magnitude perception was comparable between participant groups when peak pressure was divided by maximal inspiratory pressure.
A multi-trial, retrospective analysis of the antihypertensive effects of high-resistance, low-volume inspiratory muscle strength training
Authors: Craighead Daniel H. , Tavoian Dallin , Freeberg Kaitlin A. , Mazzone Josie L. , Vranish Jennifer R. , DeLucia Claire M. , Seals Douglas R. , Bailey E. Fiona
Published: September 2022

In young-to-older adult men and women, 6 wk of high-resistance inspiratory muscle strength training lowers casual systolic and diastolic blood pressure by 9 mmHg and 4 mmHg, respectively, with initial reductions observed by week 2 of training. Given blood pressure outcomes with the intervention were only slightly altered by subject baseline characteristics (i.e., age, blood pressure medication, and health status), inspiratory muscle strength training is effective in lowering blood pressure in a broad range of adults.
MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers
Authors: Yang Pin
Published: September 2022

In order to solve the problem of the difference in the diagnostic effect of different sequences of magnetic resonance imaging (MRI) examinations for anterior and posterior cruciate ligament injuries, the author proposes an MRI rehabilitation method to relieve anterior cruciate ligament injury in dancers. This method retrospectively analyzed the clinical data of 60 patients with knee anterior and posterior cruciate ligament injuries in our hospital, and all patients were diagnosed with knee anterior and posterior cruciate ligament injuries. All patients underwent MRI 3D sequence and 2D sequence examination successively to compare anatomical measurements. This study aimed at comparing the measurements of the posterior cruciate ligament (PCL) and anterior cruciate ligament (ACL) between the two examination sequences; comparing the diagnosis; comparing the grading and judgment of the anterior and posterior cruciate ligament injuries of the knee joint between the two inspection sequences; and comparing the diagnostic coincidence rates of the two examination sequences in the complete tear of the anterior and posterior cruciate ligaments of the knee. Experimental results show that, in terms of PCL and ACL, the angle, thickness, and length of two-dimensional MRI examination were significantly different from those of MRI examination and anatomical measurement (

P
<
0.05

); for PCL and ACL, the angle, thickness, and length of 3D MRI were not significantly different from anatomical measurements (

P
>
0.05

). The diagnostic accuracy of 2D MRI was 83.33%, which was lower than 95.00% of 3D MRI (

P
<
0.05

). There was no significant difference in the grading of anterior and posterior cruciate ligament injuries between the two examination sequences (

P
>
0.05

). The diagnostic coincidence rates of 3D MRI and 2D MRI for complete tear of the anterior and posterior cruciate ligaments were 95.55% and 80.00%, respectively (

P
<
0.05

). In conclusion, three-dimensional MRI examination can obtain higher diagnostic value for patients with knee joint anterior and posterior cruciate ligament injury.
Sparse Spatial Spectral Fitting with Nonuniform Noise Covariance Matrix Estimation Based on Semidefinite Optimization
Authors: Guo Tuo , Bi Yang , Feng Xian , Yan Luoheng
Published: September 2022

In general, the azimuth estimation in array signal processing is derived under the assumption of uniform white noise, whose covariance matrix is a scaled identity matrix. However, in practice, the noise can be nonuniform with an arbitrary unknown diagonal covariance matrix. In this paper, the estimation of the noise covariance matrix is formulated into a solution to the semidefinite optimization problem which can obtain a more accurate sensor noise covariance matrix. In the proposed algorithm, the estimated nonuniform noise is subtracted from the sample covariance matrix. The simulation results show that the proposed algorithm can significantly improve the performance of the sparse spectrum fitting algorithm in nonuniform noise case, while the classic SpSF algorithm is used under uniform white noise assumption. The water pool experiments show that there are indeed significant differences in the noise covariance of the sensors.
Accurate Real-Life Chinese Dish Recognition
Authors: Lan Shanzhen , Wan Chengjuan , Pang Yuxuan , Jin Mingxue , Yu Shaode
Published: September 2022

Deep learning is a new research direction in the field of machine learning, which was introduced into machine learning to bring it closer to its original goal. Accurate dish recognition becomes increasingly important in the multimedia community since it can help cuisine recommendation, calorie management, service improvement, and other food computing tasks. Many novel approaches have been developed on web recipes and menu pictures, while few are concerned real-life dish image analysis. In this study, a deep learning-based prototype system is deployed in a Chinese canteen, and 28 dish types, 16,904 images, and 45,061 instances have been collected. Specifically, in the prototype system, three practical issues are explored, including the backbone network selection, the training strategy determination, and the minimum number of samples for model upgrading. Experimental results suggest that fine-tuned Faster-RCNN can serve as the backbone network of the prototype system since it outperforms the other four fine-tuned networks on dish recognition (accuracy, 98.10%; recall, 97.20%; MAP (mean average precession), 98.30%) and satisfies real-time requirement (0.15 second per image). Meanwhile, the transferred backbone network achieves superior results (MAP, 96.48%) over the same architecture trained from image scratches (MAP, 87.84%). On model upgrading, a good (MAP, 91.34%) to better (MAP, 96.48%) outcome is obtained when the training size is increased from 50 to 200 samples per dish type, and 150 and more instances should be annotated if a new dish type is added to the system’s recognition list. Conclusively, the real-life deployment and evaluation of the prototype system indicate that deep learning is full of potential to enhance customer experience through accurate daily dish recognition.
Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism
Authors: Wu Suwen , Cui Yutong , Zhao Huanqiang , Xiao Xirong , Gong Lili , Xu Huangfang , Zhou Qiongjie , Ma Duan , Li Xiaotian
Published: September 2022

Preeclampsia is regarded as an evolution-related disease that has only been observed in humans and our closest relatives, and the important factor contributing to its pathogenesis is endothelial dysregulation secondary to a stressed placenta. Hypoxia-inducible factor 1 subunit alpha (HIF1α), a highly conserved molecule in virtually all mammals, is regarded as a crucial regulator of the hypoxia adaptation and evolution. Persistent high expression of HIF1α in the placenta is one of the pathogenic mechanisms of preeclampsia. Therefore, human-specific molecules should link increased HIF1α to preeclampsia. We reported that urothelial cancer associated 1 (UCA1) is a potential mediator because it is a human-specific long noncoding RNA (lncRNA) that is upregulated in placental tissues and maternal serum from women with preeclampsia and is regulated by HIF1α. The cellular HIF1α-UCA1 pathway promoted the adaptation of trophoblasts to hypoxia by inducing vascular endothelial growth factor (VEGF) secretion and changes in the levels of key enzymes in glycolysis. On the other hand, circulating exosomal UCA1 secreted from stressed trophoblasts induced vascular endothelial dysfunction, especially excess ROS production, as measured by exosome extraction and a coculture system. At the molecular level, UCA1 physically bound to ubiquitin-specific peptidase 14 (USP14), which is a deubiquitinating enzyme, and UCA1 functioned as a scaffold to recruit USP14 to profilin 1 (PFN1), an actin-binding protein contributing to endothelial abnormalities and vascular diseases. This ternary complex inhibited the ubiquitination-dependent degradation of PFN1 and prolonged its half-life, further activating the RhoA/Rho-kinase (ROCK) pathway to induce ROS production in endothelial cells. Taken together, these observations suggest a role for the evolution-related UCA1 in the HIF1α-induced adaptive pathogenic mechanism of preeclampsia, promoting the survival of hypoxic trophoblasts and injuring maternal endothelial cells.
Seismic Performance of Super High-Rise Building Structure with Dual Lines of Defense Based on Response Surface Optimization Algorithm
Authors: Zheng Lei , Liu Zonghui , Dang Hongwei , Guo Xin , Wu Yonghua
Published: September 2022

In order to improve the safety performance of supertall buildings under earthquake, a seismic performance analysis method of double lines of supertall buildings based on a response surface optimization algorithm is proposed. Firstly, the structural performance indexes of super high-rise buildings are selected, and on this basis, the material constitutive model is constructed by the structural elastic-plastic analysis method to complete the seismic design of the first line of defense. Then, the response surface method is used to optimize the material constitutive model and complete the seismic design of the second line. Finally, the anticollapse limit state analysis method is used to determine the seismic performance of the double line of super high-rise building structures. The experimental results show that the proposed analysis method has high seismic performance, and the axial compression ratio of wall and column is always stable, in which the column is always at about 0.5 and the wall is always at about 0.26, which lays a foundation for the safety performance of super high-rise building structures under earthquake.
Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis‐Like Skin Inflammation
Authors: Bak Seon Gyeong , Lim Hyung-Jin , Won Yeong-Seon , Lee Soyoung , Cheong Sun Hee , Lee Seong Jin , Bae Eun Young , Lee Seung Woong , Lee Seung Jae , Rho Mun-Chual
Published: September 2022

Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4‐dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF‐α)/interferon gamma (IFN‐γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB‐induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.