bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review on the Effect of Physical Therapist Delivered Ergonomic Intervention on Workers in a Physically Taxing Workplace
Authors: Peter Leininger  , Joshua Prall  , Michael Ross
Published: April 2022

Background: Musculoskeletal injuries have increased in the past decade, and this has caused a sequela of pain and missed work time due to injuries. The aim of this study was to determine the effect of physical therapist delivered ergonomic intervention on workers in a physically taxing workplace. A systematic review was performed, which evaluated changes in pain and functional status of injured workers when ergonomic interventions were delivered by physical therapists. Methods: A literature search of ProQuest Central, Science Direct, PubMed, Taylor and Francis and EbscoHost was conducted using PEDro guidelines. The search limits and selection criteria were employed. A systematic review of literature using PEDro guidelines was used. In total, six RCTs met the selection criteria. Conclusion:Moderate to strong mixed evidence exists to show the effect physical therapist can have on providing workplace solutions to improve function and decreases pain with employees in a physically taxing workplace
Evaluate Scapular Asymmetry among Office Workers Having Ergonomic Risk Due to Work From Home During Lockdown– Cross Sectional Study
Authors: Pracheta Raval  , Bhavya Gandhi  , Mansi Khalasi  , Prachi Patel
Published: April 2022

Unprecedented movement restrictions have been imposed due to Covid19 Pandemic induced shutdowns. The situation had triggered organization encouraging workforce to work remotely entirely or partially. The situation has implied prolonged stays at home and radical lifestyle changes including alterations in aspects like physical activity (PA), eating habits, mental health, and quality of sleep. Prolonged working hours and faulty sitting posture has accelerated onset of work related musculoskeletal disorders (WMSDs). Scapular Asymmetry (Scapular Dyskinesia) is one of common problems, which is directly or indirectly associated with poor ergonomics.Aim of the study is to evaluate scapular asymmetry contributed due to ergonomic risk among office workers practicing sedentary lifestyle in work from home environment during lockdown.Target group of this study was persons who had been assigned remote work (Most subjects from MNCs and IT Sector) in Surat, of which total 100 subjects, 67 males and 33 females, participated and were of 25 to 55 years of age-group. The scapular asymmetry was assessed by using Lateral Scapular Slide Test (LSST) and Rapid Upper Limb Assessment (RULA) scale.Results analyzed with SPSS statistical software (version 21), showed 58% prevalence of scapular asymmetry. Correlation analysis between RULA scores and LSST average of all three position of both right and left side was r = 0.243, which indicates positive correlation between RULA and LSST.Hence, the results conclusively establish that the prevalence of scapular asymmetry is higher among office workers working remotely having ergonomic risk in lockdown
Effect of Knowledge and Awareness Regarding Urinary Incontinence and Its Treatment Options in Female Dancers
Authors: Prajakta Chavan  , Rima Musale  , Vaibhavi Mahendrakar  , Neha Bhosale
Published: April 2022

Background: Urinary incontinence is involuntary loss of urine so as to cause hygiene and/or social inconvenience for day-to-day activities. Urinary incontinence is a common problem in females. As dancers begin training at young age there is potential for great impact on their future health, secondly the interplay of physical and aesthetic demands in dance may lead to various health issues including Urinary Incontinence. Objective of this study is to find out the effect of knowledge and awareness regarding urinary incontinence in female dancers. Methods: Permission was taken from institutional level ethical committee and from dancers. In this analytical type of study, 50 dancers between 18-35 years of age were selected according to convenient sampling method. Dancers who have chronic asthma, undergone any abdominal surgery, not willing to participate were excluded from the study. Knowledge and awareness were checked pre and post intervention by Urinary incontinence quiz and urinary incontinence knowledge scale.Results: Data was statistically analysed using Wilcoxon test. Incontinence quiz score pre intervention mean 6.48±2.01 was and post intervention mean was 11.32±1.71 with p<0.0001 which is extremely significant, For incontinence knowledge scale the pre intervention mean was 15.72±3.32 and post intervention mean was 24.2±2.81 with p <0.0001 which is extremely significant.
Effect of Lumbopelvic Manipulation Versus Tibiofemoral Mobilization on Pain and Quality of Life in Patellofemoral Pain Syndrome
Authors: R Mukesh Kumar  , Benazir Shereief
Published: April 2022

Background: Patellofemoral pain syndrome is a common source of anterior knee pain which accounts for 25-40 percent of all knee problems seen in sports injuries. It is a sharp or dull pain in anterior or retro patellar knee pain that can be aggravated by sustained sitting, squatting, step up and step down. Therapeutic exercise, bracing, taping and orthotics have shown improvement in the treatment of PFPS. Manual therapy also shows little evidence in the management of PFPS. Objective: The objective of this is to find the effectiveness of Lumbopelvic manipulation versus Tibiofemoral mobilization on pain and quality of life on Patellofemoral pain syndrome.Methodology: This clinical trial was conducted 50 subjects with patellofemoral pain syndrome. The subjects were selected based on inclusion and exclusion criteria. Baseline assessment was taken and participants were allocated to either Group A LPM (n=25) or Group B TFM (n=25) based on inclusion criteria. Both the techniques were given for 3 days in a week for 4 weeks. Outcome measures NPRS and Kujala anterior knee pain were done at the baseline, 1st week and at 4th weeks after intervention. Outcome measures were compared and used to established an effectiveness of treatment.Result: The baseline characteristics age, gender, duration of pain, NPRS and KAKS score were calculated for both the groups. The pre-test and post-test difference for NPRS score is 2.12 and 1.56 for Group A (LPM) and Group B (TFM) respectively and for KAKS score is 7.88 and 7.32 for Group A (LPM) and Group B (TFM) respectively. These results show there is no statistically significant difference between both the groups. Hence, both the technique found to be equally effective and no technique is superior to the other.Conclusion: There is no significant difference between Lumbopelvic manipulation Versus Tibiofemoral mobilization on pain and quality of life in Patellofemoral pain syndrome
A Comparative Study on the Effects of Task Oriented Balance Training Program with or without Altered Sensory Input on Balance and Functional Performance in Older Adults : A Case Control Study
Authors: Rinku Roshan  , Sam Thamburaj
Published: April 2022

Background and purpose: This study was designed to compare the effectiveness of task oriented balance training program with altered sensory input versus task oriented balance training program without altered sensory input. This helps us to choose a better training program for improving and reducing the risk of fall in elderly population Subjects: Fourty eight older adults from independent life-care communities, aged 71 to 75 years (X = 79.2, SD = 6.2), participated.Methods: Patients were divided into group A and group B. Group A received Task oriented balance training program with altered sensory input while the group B receiving task oriented balance training program without altered sensory input. Subjects were then assessed on balance scale – Berg balance scale (BBS) and Functional performance measure – Ten meter walk test (10MWT).Results: There was a significant improvement in BBS and 10MWT in patients performed Task oriented training program with altered sensory input than the patients performed Task oriented training program without altered sensory input.Conclusion: Although the obtained results reveal that subjects in both groups were benefitted from balance training interventions with a significant improvement in post intervention balance scores on BBS and functional measure, ie.10 meter walk test, subjects in group A performed better than Group B. The improvement may be as the result of increased use of somatosensory. And this sensory compensation might have improved sensorimotor integration of postural control in the central nervous system, thus serving to activate and coordinate motor processes i.e. action of proper muscle synergies.
A Comparative Study of Incidence of Musculoskeletal Injuries in Amateur and Professional Boxers
Authors: Shibani Dixit  , Shweta Naidu  , Mugdha Joshi
Published: April 2022

Boxing is the physical skill of fighting with fists.Boxing involves fusion of coordinated fast paced movements of hands and feet, dodging skill, muscular strength and high aerobic capacity. Boxing is similar to other physical activities in that there is a presumed risk of injury through participation.Previous literature suggests that 27.1-93.4 % of injuries involve the head in which most injuries are minor, with lacerations and contusions being most common.In the opinion of the authors that head and hand/wrist related injuries should be considered an inherent risk to boxing, caused by impact and equipment related factors. Thus, the present study focuses on injuries in boxers during training sessions.
Dysbiosis as a prognostic factor for clinical worsening in chronic respiratory disease: A systematic review and metanalysis
Authors:   Universidad Austral de Chile, Barros-Poblete Marisol , Torres-Castro Rodrigo , Henríquez Mauricio , Guequen Anita , Blanco Isabel , Flores Carlos
Published: April 2022

Review question / Objective: Is dysbiosis a prognostic factor for clinical worsening in patients with chronic respiratory diseases?. Condition being studied: Dysbiosis, defined as changes in the quantitative and qualitative composition of the microbiota. Eligibility criteria: Over 18 years old adult patients with chronic respiratory diseases clinical diagnosis (cystic fibrosis, chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, interstitial lung disease, sarcoidosis, bronchiectasis, non-CF bronchiectasis, pulmonary hypertension) according to the International Statistical Classification of Diseases and Related Health Problems (ICD) from OMS) and international guidelines of each disease.
Modificación del Modelo Altman Z Score: Indicador de Estabilidad Financiera
Authors: Solórzano-Hernández Reynaldo Guillermo
Published: April 2022

Una estrategia primordial del empresariado es colocar fondos en una institución financiera sólida, totalmente fuera de algún estrés económico, problemas financieros, o sospechas de inestabilidad en el tiempo. La presente investigación se elaboró con el objetivo de aplicar una modificación al modelo de Altman Z-Score como indicador de estabilidad financiera para el caso del Banco de Finanzas de Nicaragua en el año 2022. Se desarrolla bajo el método analítico-sintético, paradigma pragmático, enfoque mixto, tipo hipotético – deductivo y diseño concurrente triangular. En el factor cualitativo, apoyado por entrevistas a expertos, así como a funcionarios; con lo cuantitativo representado en una muestra de estados financieros históricos 2016 -2021, publicados por la Superintendencia de Bancos y de Otras Instituciones Financieras – SIBOIF. Se utilizó el modelo de regresión lineal múltiple como herramienta estadística, a través del programa IBM SPSS Statistics 23.0, por lo que se tendrán nuevos coeficientes y rangos de respuesta modificantes al Modelo Altman para su uso en el Banco de Finanzas. La modificación del Modelo Altman ???? Score dará un aporte sustancial a la gestión empresarial del Banco de Finanzas, apoyando a sus análisis y estimaciones financieras para una toma de decisiones eficiente; prediciendo los futuros comportamientos de estabilidad para el año 2022. Finalmente se podrá recomendar su aplicación por parte de la SIBOIF, representado una aproximación, prueba o test a ser considerada como una normativa prudencial.
Superación de Educadoras en Educación de Sexualidad Preescolar e Integración de las Tecnologías
Authors: Guzmán de Posada Daniela
Published: April 2022

La educación sexual ha cobrado un notable interés en el sector educacional, pues constituye una dimensión del ser humano expresada durante toda la vida, va más allá del conocimiento biológico, explicando procesos tan importantes como identidad de género, rol de género, orientaciones sexoeróticas y relaciones afectivas en un marco histórico-cultural concreto, el cual promueve o limita el desarrollo de la personalidad. El objetivo de esta investigación fue identificar la suficiencia y eficacia del proceso de superación de educadoras de círculos infantiles en cuanto a educación sexual preescolar e integración de las Tecnologías de la Información y la Comunicación (TIC) en el proceso educativo, en el CUM Morón (Cuba). El método utilizado fue el deductivo – inductivo, paradigma pragmático, enfoque mixto, tipo concurrente, y diseño concurrente de triangulación. La muestra de estudio fue intencional, con 40 participantes, estudiantes de la carrera Licenciatura en Educación Preescolar, vinculadas a círculos infantiles. Los instrumentos utilizados fueron entrevistas, encuesta, observación y análisis de documentos como herramientas de recolección de datos. La investigación permitió concluir con la necesidad de realizar modificaciones en el programa de la carrera de Licenciatura en Educación Preescolar, incorporando asignaturas optativas, cursos cortos sobre sexualidad preescolar y uso de TIC como herramientas para el proceso docente.
To Design and Develop 2MHz Portable Waveform Generator
Authors:   Department of ETRX, Terna Engineering College, Navi Mumbai, Maharashtra, India, Deshmukh Amit , Chaudhari Dev ,   Department of ETRX, Terna Engineering College, Navi Mumbai, Maharashtra, India, Shetye Ajinkya ,   Department of ETRX, Terna Engineering College, Navi Mumbai, Maharashtra, India, Singh Saurabh ,   Department of ETRX, Terna Engineering College, Navi Mumbai, Maharashtra, India, Ghate Ashutosh ,   Department of ETRX, Terna Engineering College, Navi Mumbai, Maharashtra, India
Published: April 2022

We plan to build a waveform generator that can be carried around. Waveform generators are utilized in circuit testing. (Take, for example, the input to a clipper or clapper circuit.) The function generator, on the other hand, has the drawback of being non-portable. As a result, we're developing a function generator that can be carried anywhere and used whenever it's needed...
A STUDY ON EFFECTIVES OF OCCUPATIONAL HEALTH AND SAFETY MANAGEMENT WITH EMPLOYEE IN BHEL COMPANY PVT LTD, TRICHY
Authors:   Research Scholar, Department of Business Administration, H.H Rajah’s College (A), Pudukkottai (Affiliated Bharathidasan University, Tiruchirappalli), Maheswari S , Gnanasekaran P ,   HOD of Business Administration, H.H. Rajah’s College (A), Pudukkottai (Affiliated Bharathidasan University, Tiruchirappalli)
Published: April 2022

This paper analyses the Effective of employees regarding the Occupational Health and Safety Management with Employee in BHEL Company Private Limited, Trichy. In this case of anticipation, recognition, evaluation and control of hazards arising from the workplace that could impair the wellbeing to Employees. It is against this background that the research project was carried out to find the effect of selected Occupational health and Safety management training on satisfaction of employees in BHEL Company Private Limited, Trichy. This study covers both primary and secondary data. The primary data were collected from the 100 sample respondents with the help of questionnaire. Secondary data were collected through various journals, magazines report and website. This study statistically tools used for t -test, ANOVA, Chi-square test. Research data have been collected from various available sources and systematically analyzed with suitable tools. This study finds out the Effective of employees regarding the Occupational Health and Safety Management of workplace on safe and healthful to the employees, Maintaining and Establishing on safe and healthful, Ensuring workers are trained or certified, as required, medical and first aid facilities, ensuring personal protective equipment is available, worker with health and safety information, supporting supervisors, knowledge regarding, policies adequate in the factory, administrators and supervisors are really concern about, employees following rules.The analysis clearly shows that the practice of occupational health and safety management practices leads to improved satisfaction among employees.
Post discharge outcomes of patients with coronavirus disease (COVID-19)
Authors:   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania, Mangaloiu David Valentin , Radulescu Mihaela ,   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Orfanu Alina ,   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Tiliscan Catalin ,   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Arama Sorin Stefan ,   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Visan Angelica ,   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Arama Victoria ,   “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: April 2022

Since WHO declared COVID-19 a pandemic, globally more than 212-million people were infected and approximately 4.4 millions died (25 August 2021). As the pandemic evolved, it became clear that there are many more things to research and discover about the SARS-CoV-2 infection. Besides the fact that SARS-CoV-2 primarily affects the respiratory system, more and more articles indicate a systemic involvement which could be responsible for long term consequences. The aim of this review was to evaluate the long- term signs and symptoms of COVID-19 infection. We looked for information regarding the prevalence and persistence of symptoms associated with COVID-19 infection and the persistence of organ dysfunction beyond the acute phase. We also searched data regarding the impact of the infection on the quality of life, physical, mental and psychosocial function. Recent studies have shown that some symptoms can persist a long time after the acute episode of COVID-19. Furthermore, organ sequalae can be present after the acute episode. The most common symptoms of “long COVID” are: fatigue and shortness of breath, lack of taste/smell, cough, myalgia and arthralgia, headache. Also, cardiac abnormalities, cognitive impairment, insomnia, anxiety and concentration issues can be present.
Hepatitis B in pregnancy – Review of literature and guideline proposal
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Bohiltea Roxana ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Calinescu Gina ,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Balan Andra Magdalena ,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Campean Doru ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Horhoianu Irina ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Georgescu Tiberiu Augustin ,   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Mihai Bianca Margareta ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Vladareanu Irina Maria ,   Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Dr. I. Cantacuzino” Clinical Hospital, Bucharest, Romania
Published: April 2022

Vertical mother-to-fetus transmission of hepatitis B virus (HBV) is a concern of public health global policies. The transmission rate can be substantially influenced by the good function of the maternal screening programs and by the vaccination of newborns as well. Also, the appropriate treatment of pregnant women and the administration of anti-HBV immunoglobulin immediately after birth come up with the decrease of HBV transmission rate. Acute viral hepatitis during pregnancy constitutes the main cause of jaundice recognized in pregnant women. It has generally a mild course during pregnancy, without significantly influencing the health state of the mother. In the context of immunological adaptation in pregnancy, the condition of the pregnant woman with chronic HBV infection without notable hepatic dysfunction generally has a good evolution. However, there are some possible clinical consequences like hepatic flares and progression of liver disease. The paper presents a review of literature and guideline proposals to prevent vertical transmission of hepatitis B virus and to provide the best possible care for pregnant women with hepatitis B infection.
The influence of the COVID-19 pandemic on lifestyle – a pilot study
Authors:   Department of Fundamental Sciences, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Zugravu Corina , Salmen Teodor ,   Doctoral School, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “N. Paulescu” National Institute for Diabetes Mellitus, Nutrition and Metabolic Disorders, Bucharest, Romania, Ducu Ionita ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Mihai Bianca Margareta ,   Filantropia Clinical Hospital, Bucharest, Romania, Dima Vlad ,   Filantropia Clinical Hospital, Bucharest, Romania, Berceanu Costin ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Craiova, Romania, Bohiltea Alexia-Teodora ,   École Hôtelière de Lausanne, Lausanne, Switzerland, Neagu Smaranda ,   Heinrich-Heine-Universität, Düsseldorf, Germany, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Balescu Irina ,   Department of Visceral Surgery, Ponderas Academic Hospital, Bucharest, Romania, Bohiltea Roxana-Elena ,   Filantropia Clinical Hospital, Bucharest, Romania,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: April 2022

Aim. Because the COVID-19 pandemic is a topic of interest in the literature due to its information dynamics and, also, to its impact on the population health status; we wanted to highlight the connection between pandemic and lifestyle, with an emphasis on eating habits. Material and methods. A questionnaire with 20 items about sociodemographic data and information about eating habits was distributed. Results. Data collected reflected how COVID-19 pandemic influenced the employment status, level of income, smoker status, consumption of fruits, vegetable, candies, sweets, chocolate and fast-food of the respondents. The reported dietary changes were reflected both positively by more regular meals, a slight increase in the consumption of fruits and vegetables, lower consumption of fast food and higher cooked food, and negatively by a higher intake of sweets, candies and chocolate and as a result of an increasing in the habit of compulsive eating. Conclusion. The trait that easily weighed on all the activities of this period is the perceived level of stress and anxiety.
Ocular toxoplasmosis – case report and literature review
Authors:   Department of Oftalmology, “Regina Maria“ Health Network, Bucharest, Romania, Barca Irina-Cristina
Published: April 2022

Ocular toxoplasmosis is a retinochoroiditis caused by Toxoplasma gondii infection, the most common cause of posterior infectious uveitis worldwide. Main features: it is a unilateral recurrent focal retinochoroiditis infection, with early manifestation after primary systemic infection, or with late manifestation after reactivation of intraretinal infectious cysts. The diagnosis is mainly clinical, being paraclinical supported by laboratory tests. Associated features: the most common is a unilateral focal ocular pathology, with multiple and bilateral active lesions occurring in a recently acquired infection or in immunocompromised patients. Ocular toxoplasmosis is characterized by posterior, intermediate, and anterior ocular damage; is a retinochoroiditis infection with significant involvement of the vitreous, with increased inflammation, retinal vasculitis, optic disc edema and anterior uveitis. Therapeutic management includes antiparasitic medication and corticosteroid therapy. Regarding pregnancy, it is essential to screen and capture the moment of maternal acute infection during pregnancy in patients with negative IgGs in order to treat the infection, to minimize or even prevent transplacental passage.
Management of fetal congenital heart block in pregnancies with anti-Ro antibodies
Authors:   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Panaitescu Anca Maria ,   “Filantropia” Clinical Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania, Peltecu Gheorghe ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “Filantropia” Clinical Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania, Gica Nicolae ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “Filantropia” Clinical Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania
Published: April 2022

Anti-Ro antibodies are detected frequently in the general population, but more so in patients with autoimmune conditions as Sjögren’s syndrome and systemic lupus erythematous (SLE). During pregnancy, anti-Ro antibodies can cross the placenta by hijacking physiological mechanisms and can have deleterious effects on the fetus. Administration of hydroxychloroquine (HCQ) to pregnant women with documented anti-Ro antibodies has been shown to prevent congenital heart block (CHB). Serial fetal ultrasound scans and echocardiograms are controversial in pregnant women with anti-Ro antibodies. When complete CHB is diagnosed, this is irreversible and can lead to fetal heart failure, hydrops, and death. After delivery, babies with complete CHB require pacemaker. In the presence of maternal anti-Ro antibodies, there is a high risk of recurrence of CHB for future pregnancies, if there is a previously affected child. Adequate counselling and prophylactic treatment with HCQ should be encouraged.
Clinical updates on systemic lupus erythematosus in pregnancy – the maternal-fetal medicine perspective
Authors:   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Panaitescu Anca Maria ,   “Filantropia” Clinical Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania, Peltecu Gheorghe ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   “Filantropia” Clinical Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania, Gica Nicolae ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   “Filantropia” Clinical Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania
Published: April 2022

Systemic lupus erythematosus (SLE) is common in women of reproductive age and can have serious consequences on pregnancy outcomes. Recent updates in the clinical management of this condition have brought improvements for mothers affected and their babies. The aim of this general review is to offer the perspective of the maternal-fetal medicine specialist on the recent updates in clinical management of SLE in pregnancy and to bring into the attention of the rheumatology specialists the tools that obstetricians have nowadays in monitoring high-risk pregnancies.
Managing comorbidities in spondyloarthritis patients – to what extent do rheumatologists carry the burden?
Authors:   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania, Cobilinschi Claudia ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Cobilinschi Cristian ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Intensive Care Unit, Clinical Emergency Hospital, Bucharest, Romania, Constantinescu Alexandra ,   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania, Abu Abid Adel ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Ruxandra ,   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Opris-Belinski Daniela ,   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania
Published: April 2022

Objective. The spondyloarthritis group comprises chronic inflammatory conditions that share clinical, genetic and radiographic features. The impact of comorbidities on disease activity is not entirely known. The aim of this study is to identify the frequency and management of comorbidities in SpA patients. Materials and methods. A six-month retrospective study included 235 SpA patients for whom demographic, disease data and associated comorbidities were collected, according to EULAR’s designated categories. Statistical analysis was performed using Microsoft Excel. Results. 71% were males, with a mean age of 42.3, suffering from SpA for more than 15 years. 60% patients were overweight or obese, 25% had been diagnosed with hypertension, 28% were smokers. 18% suffered from dyslipidemia and 9% had type II diabetes. 16% had hepatitis B while 2% had C viral infection, 14% had previous mild to moderate urinary or pulmonary infections. Osteoporosis was confirmed in 6% and malignancies in 2.5% cases. Conclusions. The most frequently encountered comorbidities were cardio-vascular events, followed by gastro-intestinal disorders. SpA patients require early comorbidity detection with the aid of their rheumatologist and a multidisciplinary care to avoid additional disease burden.
Complete, refractory dysphagia in a dermatomyositis patient with positive anti-NXP-2 antibodies
Authors:   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania, Cobilinschi Claudia ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Cobilinschi Cristian ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Intensive Care Unit, Clinical Emergency Hospital, Bucharest, Romania, Constantinescu Alexandra ,   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania, Ionescu Ruxandra ,   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Opris-Belinski Daniela ,   Rheumatology and Internal Medicine Department, “Sf. Maria“ Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: April 2022

Dermatomyositis (DM) is a rare autoimmune disorder defined by weakness of the striated muscles and a distinctive skin rash. Dysphagia is a serious symptom that can be difficult to manage, severely impacting quality of life and long-term survival. The aim of this report is to highlight a case of an anti-NXP-2 positive DM with severe dysphagia refractory to multiple therapies, including steroids, cyclophosphamide and intravenous immunoglobulins. Anti-NXP-2 autoantibodies indicate a specific disease phenotype adding severe muscle weakness, dysphagia, peripheral edema and underlying malignancy.
Artificial Intelligence-based Colon Cancer Prediction by Identifying Genomic Biomarkers
Authors: PAKSOY Nur , YAĞIN Fatma Hilal
Published: April 2022

Aim: Colon cancer is the third most common type of cancer worldwide. Because of the poor prognosis and unclear preoperative staging, genetic biomarkers have become more important in the diagnosis and treatment of the disease. In this study, we aimed to determine the biomarker candidate genes for colon cancer and to develop a model that can predict colon cancer based on these genes.Material and Methods: In the study, a dataset containing the expression levels of 2000 genes from 62 different samples (22 healthy and 40 tumor tissues) obtained by the Princeton University Gene Expression Project and shared in the figshare database was used. Data were summarized as mean ± standard deviation. Independent Samples T-Test was used for statistical analysis. The SMOTE method was applied before the feature selection to eliminate the class imbalance problem in the dataset. The 13 most important genes that may be associated with colon cancer were selected with the LASSO feature selection method. Random Forest (RF), Decision Tree (DT), and Gaussian Naive Bayes methods were used in the modeling phase.Results: All 13 genes selected by LASSO had a statistically significant difference between normal and tumor samples. In the model created with RF, all the accuracy, specificity, f1-score, sensitivity, negative and positive predictive values were calculated as 1. The RF method offered the highest performance when compared to DT and Gaussian Naive Bayes.Conclusion: In the study, we identified the genomic biomarkers of colon cancer and classified the disease with a high-performance model. According to our results, it can be recommended to use the LASSO+RF approach when modeling high-dimensional microarray data.
Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland
Authors: ERDAL Muhammed , ALTUNKAYNAK Zuhal , KOCAMAN Adem , ALKAN İşınsu , ÖZTAŞ Emin
Published: April 2022

Aim: The interaction between obesity and increased production of pro-inflammatory cytokines results the existence of inflammation HMGB1 secreted from the adrenal gland can play a role in inflammation pathways. The aim of this study is to explain the link between HMGB1 and obesity in the adrenal gland. Material and Methods: In this study; eighteen female Wistar Albino rats were divided into two groups: untreated control group (n=8) and obese group (n=10). The rats in obese group were fed with high fat diet for ten weeks. Morphometric parameters of adrenal gland were assessed by using stereological techniques. The expression of high mobility group box protein 1 (HMGB1) in adrenal gland was evaluated. Results: At the end of the analyses; mean volumes of zona fasciculate, zona reticularis, and medulla were significantly increased in obese group. Also, the number of HMGB1 stained cells was significantly increased in the obese group in comparison to control group.Conclusion: The results suggest that obesity may be one of the reasons of inflammation and hypertrophy in the adrenal gland. HMGB1 may provide a novel perspective into the anti-inflammatory therapeutic strategies in obese patients.
Nutritional Status Associated to Red Cell Distribution Width, Length of Stay, and Clinical Outcome patient with Chronic Kidney Diseases
Authors: Rahmiyanti Layle , Rasyid Haerani , Taslim Nurpudji Astuti , As’ad Suryani , Bukhari Agussalim , Aminuddin Aminuddin
Published: April 2022

INTRODUCTION: Red cell distribution width (RDW) shows the heterogeneity of erythrocyte size associated with inflammation and various clinical conditions including in patients with chronic kidney disease (CKD). Systemic inflammation and oxidative stress were commonly found in CKD patients.

AIM: This study aimed to examine the relationship of nutritional status, length of hospital stay (LOS), and clinical outcome to RDW in CKD patients.

METHODS: We conducted a retrospective cohort study of 1736 patients CKD patients who admitted from January 2017 to August 2020, aged between 18 and 60 years and were hospitalized at Wahidin General Hospital. From those, 239 were consulted with clinical nutrition specialist, of which 59 patients eligible with the criteria inclusion. Data were collected through medical records and through electronic data (biochemical data). RDW was categorized into normal and high RDW group, nutritional status based on subjective global assessment (SGA), LOS <10 days and clinical outcome based on conditions at the time of hospital discharged. Data were analyzed using SPSS version 25.0.

RESULTS: The data of 59 patients were analyzed, the mean age was 50.42 years (normal RDW) and 47.24 years (high RDW), most of them are women (57.7% vs. 60.6%). There were 42 patients with moderate malnutrition (23 normal RDW and 19 high RDW) and 17 patients with severe malnutrition (3 normal RDW and 14 with high RDW). The study found a significant differences between normal RDW and high RDW (p 0.021), but not significant differences in LOS (p 0.890) and clinical outcome (p 0.968). There were a significant differences in the levels of hemoglobin (p = 0.001), RBG (p = 0.030), and serum sodium level (p = 0.010). Patient with LOS < 10 days had lower sodium levels and more severe anemia when compared with LOS > 10 days and the poor clinical outcome had a heavier degree of anemia compared to the good clinical outcomes.

CONCLUSION: Poor nutritional status was associated with an increase in RDW, degree of anemia, and sodium level.
A Mixed-Methods Exploration of Implementation of a Healthy School Canteen Program after a Year Intervention
Authors: Fudla Hadiyati , Pratiwi Azizah Ajeng , Tarmizi Nurul Azma Ahmad , Meiyetriani Eflita , Wangge Grace , Pramesthi Indriya Laras , Ananda Aziz Jati Nur , Anggraini Roselynne , Iswarawanti Dwi Nastiti , Ermayani Evi
Published: April 2022

Background: Previous studies have shown that adolescents prefer less healthy food and their eating habits will affect their nutritional status in adulthood and old age. School canteen is a part of food retailing and provisioning that influence the diet quality of the adolescents. Healthy school canteen intervention is recommended as one of the public health strategies in supporting the development of healthy diet behavior. 
Objectives: To evaluate the effects of a healthy school canteen intervention program among middle school children. 
Methods: A mixed-methods research design including focus group interviews for teachers and principal, observation on school canteen, a survey for food handlers and food testing for hazardous chemicals. Thematic analysis of focus group data and descriptive analyses of survey data were conducted. Four schools were selected as intervention groups and four schools as positive control groups. Data collection phase took place between April 22 and May 2, 2019. 
Results: Only one school out of eight schools that had written commitment and a food safety team. In intervention school 50% of food handlers use personal protective equipment and 25% of food handlers received training. In the positive control group, none of the food handlers used personal protective equipment and they had not received any training. Food handlers in the positive control group have a higher rate of correct answers. Only 2 out of 4 schools in the intervention group had nutritious foods available in the canteen and 3 out of 4 schools in the positive control group. None of the school canteens were found positive for metanil yellow. Higher positive findings for Rhodamin B, Formaldehyde and Borax (33.3%, 60.0%, 33.3%, respectively) in the control group compared to the control group (28.6%, 27.3%, and 28.6%, respectively). 
Conclusions: Intervention groups have been slightly more successful in creating healthy school canteens, as they had a slightly better total score in the observation sheet compared to the schools from the positive control group. Collaboration with another stakeholder such as Primary Health Center (PHC) can be thought of as a solution to train food handlers about healthy practice while handling the food.
The Nutritional Problems of Adolescents among the Traditional Community of Suku Anak Dalam in the Working Area of Pematang Kabau Health Center, Sarolangun
Authors: Sari Mila , Merita Merita , Wulansari Arnati , Faridah Faridah , Prabowo Dyan Heru
Published: April 2022

Background: Adolescents in traditional community of Suku Anak Dalam (SAD) are a group that susceptible to experiencing nutritional problems and their nutritional status needs to be considered, because it is a transitional period from childhood to adulthood who live as marginalized.   Objectives: This study aims to know the nutritional problems of adolescents among the traditional community of SAD in the working area of the Pematang Kabau Health Center, Sarolangun District.   Methods: This study used a cross sectional study design which was conducted in the working area of Pematang Kabau Health Center in July until August 2020. The sample in this study was 30 adolescents with a purposive sampling. Measuring instruments used include microtoice, scales and 2 times 24-hours food recall questionnaire. Data were collected by conducting guided interviews using a questionnaire and direct measurement of nutritional status. The data analysis used univariate analysis.   Results: The results showed that a large proportion SAD adolescents have normal nutritional status (83.3%), poor eating habits (56.7%), adequate levels of macronutrients are deficits (80%), no food taboo (76.7%), and parental education is low (100%).   Conclusions: Based on the results of the study, it can be concluded that there are still nutritional problems in adolescents with SAD, especially in the aspects of consumption and eating habits. Therefore, it is hoped that nutrition and health workers will be active in providing regular education to SAD adolescents so as not to cause nutritional problems
Lowering Breast Pain Postpartum Cabbage (Brassica Var Capitata) and Aloe vera Compress
Authors: Usman Hastuti , Sumiaty Sumiaty , Silfia Niluh Nita , Sakti Putri Mulia , Liana Sarliana , Rinawati Rinawati
Published: April 2022

BACKGROUND: Pain was the body’s way of telling us that something was wrong. Breast engorgement caused pain which affected the breastfeeding process. In the Kamonji Health Center area, there were 47 postpartum mothers who experienced breast pain

AIM: The purpose of this study was to determine the difference in the effectiveness of giving cabbage compresses (brassica oleracea var capitata) with Aloe vera compresses to reduce breast swelling pain in postpartum mothers in the Kamonji Health Center area

METHODS: This type of research was quasi-experimental with a two-group pretest–posttest design. The sampling technique was consecutive sampling with samples n1 = n 2 = 15 for each group of cabbage compresses and A. vera compresses. Data processing used the paired sample t-test.

RESULTS: The results showed that the reduction of breast pain in postpartum mothers by giving cabbage compresses (brassica oleracea var capitata) was more effective than A. vera compresses with an average difference of 0.267. However, the second intervention has the same effectiveness in reducing breast pain in postpartum mothers, this can be assumed by the significant value of the second intervention is 0.000 p < 0.05

CONCLUSIONS: This study concluded that postpartum mothers who experienced breast swelling pain could apply cabbage compresses with A. vera compresses as a non-pharmacological therapy to reduce breast swelling.
Rapid Growth in Malnutrition Children Associated with Higher Systolic Blood Pressure in Adolescent
Authors: Arini Firlia Ayu , Achadi Endang , Besral Besral
Published: April 2022

BACKGROUND: Several studies found that children experiencing rapid growth earlier in life might increase the risk of chronic disease. Cardiovascular disease and hypertension are common risk factors and have been the leading cause of death worldwide. However, studies investigating the effects of rapid growth in early life on blood pressure later in life are limited.

AIM: This study aimed to analyze the association between rapid growth after the first 1000 days of life and blood pressure at 17−19 years old.

METHODS: We analyzed 17-year follow-up cohort using secondary data from the Indonesian Family Life Survey from the second (1997), third (2000), and fifth wave (2014). The survey was conducted in 13 provinces in Indonesia. No more than 672 children under 2 years old were included in the study. Rapid growth was defined as an alteration in length or height-per-age and weight-per-age z-score, based on WHO Child Growth Standard, on 1997 and 2000 time frame which was greater than 0.67, experienced by children with malnutrition (low birth weight, stunted, underweight, and wasting). Blood pressure was measured three times by an oscillometric method in 2014. In addition, we used a one-way ANOVA (analysis of variance) test to assess the association of rapid growth on systolic blood pressure.

RESULTS: Malnutrition children at 0-2-year-old that grow rapidly in length or height, had higher systolic blood pressure than normal children (p = 0.029). In contrast, there was no difference observed in systolic blood pressure in children with malnutrition and children who did not experience rapid growth in weight.

CONCLUSIONS: Children who had a history of malnutrition earlier in life (0−23 months) and had rapid growth in length or height after the first 1000 days of life had higher systolic blood pressure than normal children and children with malnutrition who did not grow rapidly.