bluuebunny/crossref_metadata_2025 huggingface dataset:
Survai Analisis Sarana dan Prasarana LRT Sumatera Selatan Dalam Menghadapi Covid-19
Authors: FIRDAUSA FADHILA , Artini Sri Rezki , Prayuda Hakas
Published: January 2022

ABSTRACTArticle title in English:The Covid 19 pandemic that has occurred for one year has made all activities experience social restrictions and the application of strict health protocols. Besides that, through this pandemic the community is expected to continue their activities as usual. This of course causes new habits and has a huge impact on the pattern of life today. The spread of covid 19 has made the use of public facilities a major highlight during this pandemic. South Sumatra Light Rail Transit (LRT) is a mode of public transportation in Palembang city. This LRT connects from the Sultan Mahmud Badarudin II airport station in Palembang City to the DJKA station in Banyuasin Regency. This study discusses the analysis of South Sumatra LRT facilities and infrastructure in the face of the Covid 19 pandemic. The methods used are survey and interview methods. The guidelines used refer to the Decree of the Minister of Health of the Republic of Indonesia Number Hk.01.07 / Menkes / 382/2020 concerning Health Protocols for Communities in Places and Public Facilities in the Context of Prevention and Control of Corona Virus Disease 2019 (Covid-19). The survey method was carried out in each LRT station, namely 13 stations and within the LRT itself. From the results obtained, it can be concluded that the facilities and infrastructure of the South Sumatra LRT have implemented the proper health protocol and in great shape.Keywords: covid 19; analysis; facilities and infrastructure; LRT, South Sumatera.ABSTRAKPandemi covid 19 yang telah terjadi selama satu tahun membuat seluruh aktivitas mengalami pembatasan sosial dan penerapan protokol kesehatan yang ketat. Disamping itu dalam melalui pandemi ini masyarakat diharapkan tetap melakukan aktivitasnya seperti biasa. Hal ini tentu menyebabkan kebiasaan baru dan sangat berakibat besar dalam pola kehidupan saat ini. Penyebaran covid 19 membuat penggunaan fasilitas umum menjadi sorotan utama dalam masa pandemi ini. Light Rail Transit (LRT) Sumatera Selatan merupakan moda transportasi umum yang ada di perkotaan Palembang. LRT ini menghubungkan dari stasiun bandara Sultan Mahmud Badarudin II yang berada di Kota Palembang ke stasiun DJKA yang berada di Kabupaten Banyuasin. Penelitian ini membahas mengenai analisis sarana dan prasarana LRT Sumatera Selatan dalam menghadapi pandemi Covid 19. Metode yang digunakan menggunakan metode survey dan wawancara. Pedoman yang digunakan mengacu pada Keputusan Menteri Kesehatan Republik Indonesia Nomor Hk.01.07/Menkes/382/2020 Tentang Protokol Kesehatan Bagi Masyarakat Di Tempat Dan Fasilitas Umum Dalam Rangka Pencegahan Dan Pengendalian Corona Virus Disease 2019 (Covid-19). Metode survey dilakukan disetiap stasiun LRT yaitu sebanyak 13 stasiun dan didalam LRT itu sendiri. Dari hasil yang didapat dapat disimpulkan bahwa sarana dan prasarana LRT Sumatera Selatan telah menerapkan protokol kesehatan yang ketat dan dalam kondisi sangat baik.Kata Kunci: covid 19; analisis; sarana prasarana; LRT; Sumatera Selatan
El test de proporcionalidad y la calificación del peligro de fuga para dictar prisión preventiva
Authors: Yrigoin Herrera Yoli Marleni
Published: January 2022

El presente trabajo de investigación tuvo como objetivo determinar si se aplica el test de proporcionalidad en la calificación del peligro de fuga para dictar la prisión preventiva en los Juzgados de Investigación Preparatoria de Chachapoyas, 2019. La investigación fue de tipo cualitativa, de diseño no experimental, transaccional descriptivo y correlacional. Para la recolección de datos se utilizó la ficha de recojo documental. La muestra estuvo conformada por diecinueve resoluciones que resuelven dictar prisión preventiva. De los resultados se ha obtenido que, en el 100% de las resoluciones analizadas si se ha motivado los criterios del arraigo (domiciliario, familiar, laboral y la facilidad de fuga) al momento de dictar la prisión preventiva. Respecto al presupuesto de obstaculización se obtuvo que el 63% fueran motivadas con el presupuesto de obstaculización para que se dicte la prisión preventiva y en un 37% no fue motivado éste presupuesto. El 100% de las resoluciones analizadas mediante las cuales se dicta la prisión preventiva no fueron motivadas en el test de proporcionalidad en sus tres sub principios. 
Omisión del debido procedimiento y prescripción en la Dirección Regional de Salud, Amazonas, 2017 - 2018
Authors: Carrión Ramos Janine Giovanna , Tejada Muñoz Sonia , Guevara Aranda Roberto
Published: January 2022

Esta investigación se realizó con el objetivo de determinar la omisión del debido procedimiento administrativo que genera la prescripción en los procedimientos administrativos disciplinarios (PAD) en la Dirección Regional de Salud (DIRESA) Amazonas, Perú, 2017 y 2018. El universo muestral fue 57 resoluciones directorales que resuelven la prescripción de los PAD. La metodología de la investigación fue de tipo básico, diseño descriptivo, correlacional, retrospectivo y transversal. El instrumento utilizado fue la ficha de cotejo. Se demostró que la mayor omisión al 100% fueron dos garantías del debido procedimiento administrativo, que son: El derecho a la presunción de licitud y el cumplimiento de los plazos razonablemente. Así mismo la prescripción del 98% de los PAD se produjeron en el primer momento para el inicio del PAD. Entonces se concluye que la omisión del debido procedimiento por parte de las autoridades administrativas si generó la prescripción de los procedimientos administrativos disciplinarios. 
Frecuencia de infecciones quirúrgicas en pacientes del servicio de cirugía, Hospital II-1 Moyobamba, Perú, 2020
Authors: Gómez Santiago Yaneliz , Silva Díaz Yshoner Antonio
Published: January 2022

El objetivo del estudio fue determinar la frecuencia de infecciones quirúrgicas en pacientes del servicio de Cirugía del Hospital II-1 de la Provincia de Moyobamba, departamento de San Martín, Perú, en el período 2020. El estudio fue de nivel descriptivo. La muestra estuvo constituida por 51 historias clínicas de pacientes postoperados siguiendo un muestreo no probabilístico por conveniencia, el instrumento aplicado fue una ficha de registro de datos sobre las infecciones quirúrgicas y datos relacionados. Los resultados evidencian que del 100 % (51) de pacientes, el 35.3 % (18) tuvo herida infectada y el 64.7 % (33) tuvo herida no infectada, existiendo una frecuencia considerable de infecciones de herida quirúrgica (35.3 %) en el Servicio de Cirugía del Hospital II-1 de Moyobamba. Asimismo, las condiciones que influyeron para una mayor frecuencia de infecciones quirúrgicas fueron la duración prolongada de la cirugía y el rasurado de la zona operatoria (p<0.05). Las condiciones que no influyeron fueron: la edad, sexo, tipo de intervención, diabetes, obesidad y profilaxis antibiótica no dada (p>0.05). Se concluye que existe una alta frecuencia de infecciones de herida quirúrgica en los pacientes del Servicio de Cirugía del Hospital II-1 de Moyobamba.
Cicloturismo e vivências afetivas no meio rural. análise da rota caldo de cana, povoado São Raimundo (Maranhão, Brasil)
Authors:   Universidade Federal do Maranhão (Brasil), Carvalho Karoliny Diniz , Sousa Rodrigo Olavo Costa
Published: January 2022

The following analysis of bicycle tourism offers the Caldo de Caña sugarcane mead route as a way to bring tourism and valorisation of traditional culture to the rural area of São Bernardo, Maranhão. It starts with an exploratory -descriptive and interdisciplinary approach, articulating the concepts of tourism and landscape in rural areas. A survey of the attractions existing on the Caldo de Caña bike route was carried out, with the challenges and opportunities for structuring a tourist product discussed. The study points to the need to include the residents of the São Raimundo village in the expanding tourism dynamics, through strategies of mobilization and articulation with public and private initiatives, so that the tourist activity adds value to the rural environment and translates itself into better living standards and an enhanced local quality of life
La participación laboral de la mujer en el turismo aventura. El caso de estudio de la región de Valparaíso, Chile
Authors:   Universidad Andres Bello (Chile), Rebolledo Dujisin Pablo Nicolás , Fernández Briones Alicia
Published: January 2022

This research analyses the roles as assigned by gender and adventure tourism workers’ perceptions of the same in Valparaíso, Chile. This qualitative research attempts to decipher the processes involved in labour exclusion based on gender, using three techniques: interviews, non-participant observation and surveys. It was found that women’s participation in general is far inferior to men’s. Women are seen to be associated with housework, being perceived as careful and detailed, and men participating to a greater extent in activities that require strength and physical fitness. This is perceived negatively by women and not at all by men. This research then sustains that there is labour segregation in adventure tourism and that this is mainly perceived by women
Violences publiques envers les journalistes et les médias
Authors: Le Cam Florence , Pereira Fabio Henrique , Ruellan Denis
Published: January 2022

Violences publiques envers les journalistes et les médias. Introduction
Violências públicas contra jornalistas e meios de comunicação
Authors: Le Cam Florence , Pereira Fabio Henrique , Ruellan Denis
Published: January 2022

Violências públicas contra jornalistas e meios de comunicação. Introdução
Maria José Braga
Authors: Braga Maria José , Le Cam Florence , Pereira Fabio Henrique , Ruellan Denis
Published: January 2022

Propos recueillis par Florence Le Cam, Fábio Henrique Pereira & Denis Ruellan
Journalisme et plateformes
Authors: Sebbah Brigitte , Sire Guillaume , Smyrnaios Nikos
Published: January 2022

Journalisme et plateforme: De la symbiose à la dépendance - Introduction
Jornalismo e plataformas
Authors: Sebbah Brigitte , Sire Guillaume , Smyrnaios Nikos
Published: January 2022

Jornalismo e plataformas: da simbiose à dependência - Introdução
On Some Features of the Protection of the Social Rights of a Person and Citizen by Constitutional Court of the Russian Federation
Authors: Sherstneva A. V.
Published: January 2022

In the Russian Federation, the principle of the social state is enshrined at the constitutional level. Analysis of the points of view regarding the social state existing in domestic legal science gives grounds to assert that in the legal field it is associated with the formation of the second generation of human rights - social rights, their normative consolidation and the activities of the state to ensure their implementation. The absence among scientists of a unified approach to determining the essence, legal nature, and the possibility of judicial protection of social rights leads to an increase in the role of the Constitutional Court of the Russian Federation in ensuring and realizing social rights. The Constitutional Court of the Russian Federation uses as a basis the provisions on the principle of the social state in conjunction with such constitutional principles, such as equality, justice, protection of human dignity, certainty, humanism, the guarantee of the state of human and civil rights and freedoms. The article analyzes the examples of judicial practice of the constitutional Court of the Russian Federation on the protection of social rights of a person and citizen, as a result of the analysis of judicial acts some principles and features of implementation of constitutional justice in the field of protection of social rights are revealed, the conclusion is formulated on the exclusive role of the Constitutional Court of the Russian Federation in the mechanism of protecting social rights. An assessment of some constitutional amendments concerning the social sphere and powers of the Constitutional Court of the Russian Federation is given.
Cadres of the Judicial Bodies in Siberia in 1920s - Early 1930s
Authors: Buzmakova O. G. , Mikheev D. Yu.
Published: January 2022

The article examines the process of formation of the Soviet judicial personnel in Siberia in the 1920s - early 1930s. It analyzes the main acts in the field of the judicial system, considers the judicial organization in the territory of the Siberian Territory, the main requirements for judges. It is noted that the formation of the personnel of the court on the basis of party and class characteristics almost led to the paralysis of the judicial system in the region. Poor equipment of the courts, hard work in difficult Siberian conditions, low wages, party control and state interference in the administration of justice contributed to high staff turnover and poor quality of court decisions. The authors conclude that the Soviet state’s desire to ensure party and class dominance in the judicial system, including the court under strict control, led to the initial stage of the formation of the Soviet judicial system, the low professional training of the personnel of the court, the degradation of the entire justice system. The lack of proper material and technical equipment of the courts, combined with the highest professional workload, led to high staff turnover on the one hand, and low quality of court decisions on the other. However, energetic and persistent activity of workers of the Siberian ships helped to create in the region of the system of judicial institutions, thereby guaranteeing the Soviet state legitimacy on the basis of a new socialist legality.
Environmental Legal Aspects of Stimulating Innovation: EU Experience
Authors: Melnikova V. G.
Published: January 2022

In the article a research of the environmental law means and methods that have a stimulating effect on the development of new technologies is considered. The experience of legal regulation at the level of the EU and Germany in terms of the impact of environmental legal norms and standards on the creation and dissemination of new technologies is considered. Indirect tools for stimulating the creation of environmentally efficient technologies are considered on the example of legal regulation of energy production from renewable sources. The elements of the environmental legal mechanism that contribute to the development and implementation of new technologies that can be used within the framework of the developed environmental and legal mechanism for innovative development (including fixing environmental targets for a long planned period in regulatory legal acts for a long planned period, high rates payments for negative impact on the environment, systematic implementation of the “polluter pays” principle, taking into account a wide range of environmental costs).
Dignity as the Basis of the Legal Status of the Employee
Authors: Voronkova E. R.
Published: January 2022

The article concludes that the category “dignity at workplace” should become crucial for the analysis of the legal status of workers and its implementation in the labor relationship. The preservation and implementation of dignity at workplace have objective features connected with the initially “hostile” environment to dignity and the specifics of its structure. The article concludes that there is a double meaning of dignity for the legal status of employees. On the one hand, dignity as an existential value forms the basis of the legal status, and the specificity of its structure (self-respect and respect by employer; employee autonomy; self-affirmation; self-realization) is a metaphysical justification of his rights and obligations. On the other hand, as a universal moral value, dignity is the ultimate goal of the implementation of the legal status, it is a criterion for assessing labor relations.
ARCHITECTURAL RESTORATION CONCEPT IN THE MIDDLE KINGDOM EGYPT
Authors: Ванюкова Д.В.
Published: January 2022

Древние египтяне не мыслили существования без опоры на прошлое своей страны: именно в мифическое «время бога» был создан мир и заложены основы царской власти, позволяющие стране пребывать в благополучии. Не удивительно поэтому, что внимание к памятникам прошлого являлось формой почитания предков и заботы о собственном благополучии в ином мире, причем последнее иногда достигалось не только самим актом поновления памятника, но и узурпацией собственно реставрационных текстов. Наибольшую известность получила реставрационная деятельность царей эпохи Нового царства, однако впервые ощущение, что прошлое отстоит от настоящего во времени и отличается своими особенными качествами, пришло к жителям долины Нила гораздо раньше. Именно после I Переходного периода тема восстановления - страны после «времени болезни», власти царя после периода междоусобиц, архитектурных памятников, разрушенных временем и войнами, - становится особенно актуальной. В статье рассматриваются тексты гробничных надписей времени I Переходного периода и эпохи Среднего царства, содержащие сведения о деятельности владельцев по восстановлению памятников прошлого. В центре внимания автора - стела Антефа сына Миит (XI династия). Ее текст выходит за рамки стандартной для подобных памятников «реставрационной формулы», что позволяет полнее представить воззрения египтян на процесс разрушения и последующего восстановления памятника. Особенности лексики, присущие тексту со стелы Антефа, позволяют обоснованно поставить вопрос о том, какую именно цель преследовали египтяне в эпоху Среднего царства, когда занимались восстановлением памятников прошлых эпох.

In the mind of the ancient Egyptians - life was possible only because of their cultural memory - the Past was the literal mainstay of the country. It was the mythical “time of God” when the whole world was created together with the kingship, as a result of which, the country could be prosperous. It is not surprising that attention to the monuments of the past epochs was a way of venerating the ancestors and to care about one’s own destiny in another world. We even know of several cases when the restoration texts were usurped. Restoration projects of the New Kingdom are well known, but for the first time, a feeling of differences between Past and Present appeared in Egyptian culture much earlier. The XIth and XIIth dynasties connected with the time of reunion of the country after the “time of illness” (ancient Egyptian epithet for the crisis periods in their history, like the 1st Intermediate period), the restoration of kingship and architectural restoration concepts. The paper deals with the analyses of several 1st Intermediate and Middle Kingdom tomb inscriptions with “restoration formulas”, which are wider and more detailed than later ones, in the New Kingdom texts. Analyzing of peculiarities of Intef’s inscription (stela Berlin, Egyptian museum, № 13272) lexicon, the author discusses the problem of the true object of restoration acts in Egyptian culture: was the restoration of buildings the only and the main aim of Egyptians?
THE ICONOGRAPHY OF THE CHAUSATH YOGINI TEMPLES
Authors: Карлова Е.М.
Published: January 2022

В статье рассматривается нетрадиционная для индийской архитектуры типология круглых дворовых храмов, имеющих посвящение Чаусатх йогини. Они локализованы географически, и время их постройки ограничено 900-1200 гг. Приводятся примеры сохранившихся построек и их краткое описание, а также обосновывается тезис о том, что структура храма обусловлена требованиями литургии. Далее приводятся примеры круглых в плане центрических построек региона - преимущественно речь идет о реконструкциях раннебуддийских святилищ, упоминаются попытки создания круглых сооружений без перекрытия в индуистской архитектуре. В качестве родственного явления рассматриваются круглые святилища богинь-матерей, распространенные в народной ритуальной практике.

The article discusses irregular typology in Indian sacred architecture - round temples with an open courtyard, dedicated to Chausath Yogini. They are localized geographically and the time of their construction is limited to the period 900-1200. First, the author provides some examples of the best preserved buildings with their brief descriptions. She also substantiates the thesis that the structure of the temple is due to the requirements of the Liturgy. The following are examples of round centric buildings in the region - mainly the reconstructions of early Buddhist sanctuaries. Also the round structures without ceiling in Hindu architecture are mentioned. As a related phenomenon, the round sanctuaries of mother-goddesses, common in folk ritual practice, are considered.
On the duality in the architecture of postmodernism
Authors: Худин А.А.
Published: January 2022

Статья содержит в себе исследование проблемы двойственности и неоднозначности архитектурных произведений в постмодерне. Подход заключается в рассмотрении архитектурного произведения как текста и сообщения, возможного к пониманию через коммуникацию и последующее прочтение, при условии освобождения от обусловленных точек зрения, нейтрализации интерпретаций, отказа от ценностных фильтров, поиска соотнесения с альтернативными контекстами, открытия к новым переинтерпретациям, пересмотра консенсусов, поиска новых точек зрения. Отказ от нормативности и нахождения универсальных знаменателей между множественными точками зрения, бытие в состоянии полилога понимается как базис критико-деконструктивного подхода и как основа постмодернистского метода в целом, актуального в состоянии сложности и противоречивости реалий конца ХХ века.

The article contains a study of the problem of duality and ambiguity of architectural works in postmodernity. The approach is to consider the architectural work as a text and message that can be understood through communication and subsequent reading, subject to release from conditioned points of view, neutralization of interpretations, rejection of value filters, search for correlation with alternative contexts, opening to new reinterpretations, revision of consensus, search for new points of view. The rejection of normality and the finding of universal denominators between multiple points of view, being in the state of the polylogue, is understood as the basis of the critical-deconstructive approach and as the basis of the postmodernist method as a whole, actual in the state of complexity and inconsistency of the realities of the late twentieth century.
Sphere in modern architecture
Authors: Ермоленко Е.В.
Published: January 2022

С первой декады 2000-х годов начинается неожиданное возвращение сферической формы в архитектуру. Утраченный ранее интерес компенсируется многочисленными новыми зданиями, в которых сфера либо становится главным формообразующим элементом, либо является значимой частью. Статья посвящена анализу приемов использования сферы в современном зодчестве. Показан процесс замещения первоначального для традиционной культуры смыслового значения сферы как сакрального «мирового яйца» формальными композиционными приемами в новейшей архитектуре.

Since the first decade of the 2000s, an unexpected return of spherical shape to architecture begins. The lost interest is compensated by numerous new buildings in which the sphere becomes either the main formative element or a significant part. The article is devoted to the analysis of the methods of using the sphere in modern architecture. The process of replacing the original for traditional culture semantic meaning of the sphere as a sacred «world egg» with formal compositional techniques in modern architecture is shown.
Wooden skyscrapers. Traditional materials in innovative technologies of modern high-rise construction
Authors: Маевская М.Е.
Published: January 2022

Статья посвящена анализу актуальных материалов по внедрению инновационных технологий в проектировании небоскребов и высотном строительстве, созданных на основе древесины. Отдельные инженерно-технические разработки последних лет привели к невероятным достижениям в сфере деревянного строительства. Деревянные конструкции стали намного прочней, безопасней и экономичней, чем прочие материалы, используемые при строительстве высотных сооружений. Древесина как перспективный материал для возведения многофункциональных башен оказалась очень востребована в футуристических проектах 2000-х и 2010-х годов. Также с 2010 по 2018 год в Австрии, Канаде, Норвегии, Индии, Сингапуре и Франции было анонсировано и частично реализовано строительство нескольких высотных деревянных проектов. Причем с каждым годом наблюдается увеличение этажности и сложности предлагаемых архитектурных и конструктивных решений.

The article overviews the actual publications devoted to implementation of innovative technologies based on usage of wood in skyscrapers projecting and high building construction. Some of engineering and technological inventions of the recent years led to incredible achievements in wooden construction: the wooden constructions became significantly stronger, secure and less expensive than other materials used in high building construction. In result, the orientation to implementation of various wooden constructions in the newest high building architecture has taken character of visible trend. The wood as a perspective material for creation of multifunctional towers turned out to be very essential in futuristic projects of the years of 2000 and 2010. From 2010 to 2018 too in Austria, Canada, Norway, India, Singapore and France, several “wooden” high-rise projects were announced and partly realized. And, with each new year the number of floors and complexity of the planned projects is growing.
Esplanade signs: version of public space
Authors: Хомяков А.И.
Published: January 2022

В статье рассматривается уникальный опыт превращения участков бывшей разделительной зоны пограничной стены, образовавшихся в центре Берлина после ее демонтажа, в памятное публичное пространство, наделенное общегородскими и туристическими функциями: прогулочными, познавательными, рекреационными, а также содержательными мемориальными значениями.

The article examines the unique experience of transforming the sections of the former border zone of the border wall formed in the center of Berlin after its dismantling into a memorable public space endowed with citywide and tourist functions: walking, cognitive, recreational, and meaningful memorial values.
The effect of adding eggshell membrane to emulsified meat models with reduced salt in terms of structure, water-holding, and texture
Authors: Ofstad Ragni , Böcker Ulrike , Høst Vibeke , Dankel Katinka R. , Sanden Karen Wahlstrøm , Pedersen Mona E. , Rødbotten Rune
Published: January 2022

This study was conducted to evaluate the effect of adding eggshell membrane (ESM), a by-product of the chicken egg processing industry, to emulsified meat models with different NaCl concentrations. The aim was to see if ESM could help reduce the amount of NaCl that is usually added to this type of product. The effects of ESM were investigated in terms of cooking loss, water distribution, color, and texture properties using a simplified meat emulsion model with no other additives than ESM. Emulsified meat samples were made with three different NaCl concentration (0.5, 0.1, 1.5%), without and with three levels of ESM (0.5, 1.0, 1.5%). In general addition of ESM reduced cooking loss (CL), improved texture, and increased redness. Effects of ESM were explained by structural changes in the protein matrix, as shown by two different histological methods. Addition of ESM explained 86% of the variation in LF-NMR T2 relaxation times in uncooked samples, while 97% of the variation in cooked samples was explained by the NaCl concentration. FTIR micro-spectroscopic measurements revealed that samples supplemented with ESM had a higher proportion of α-helical structures and reduced amount of protein ß-sheet aggregation in samples with 1.0 and 1.5% NaCl. It was shown that ESM increased the pH of the emulsified meat, and it was therefore suggested that increased negative repulsion effects had a positive heat stabilizing effect on the protein network. The fact that the cooked samples were redder was probably related to the antioxidant effect of ESM which was measured as MDA (malondialdehyde) equivalents after in vitro digestion of the samples. ESM can thus help reduce the salt content in sausages while ESM also has a positive antioxidant effect improving color.
Mapping the Proteoform Landscape of Five Human Tissues
Authors: Drown Bryon , Jooß Kevin , Melani Rafael , Lloyd-Jones Cameron , Camarillo Jeannie , Kelleher Neil
Published: January 2022

A functional understanding of the human body requires structure-function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated functions within the cell. The term “proteoform” encapsulates this complexity at the level of chemical composition. Comprehensive mapping of the proteoform landscape in human tissues necessitates analytical techniques with increased sensitivity and depth of coverage. Here, we took a top-down proteomics approach, combining data generated using capillary zone electrophoresis (CZE) and nanoflow reversed-phase liquid chromatography (RPLC) hyphenated to mass spectrometry to identify and characterize proteoforms from human lung, heart, spleen, small intestine, and kidney. CZE and RPLC provided complementary post-translational modification (PTM) and proteoform selectivity, thereby enhancing overall proteome coverage when used in combination. Of the 11,466 proteoforms identified in this study, 7,373 (64%) were not reported previously. Large differences in protein- and proteoform-level were readily quantified, with initial inferences about proteoform biology operative in the analyzed organs. Differential proteoform regulation of defensins, glutathione transferases, and sarcomeric proteins across tissues generate hypotheses about how they function and are regulated in human health and disease.
Low adherence to treatment is a weak link in the problems of ulcerative colitis
Authors: Parfenov Asfold I. , Knyazev Oleg V. , Babayan Anait F. , Kagramanova Anna V.
Published: January 2022

Aim. To determine factors of adherence to treatment in patients with ulcerative colitis (UC).
Materials and methods. The study was performed in the department of treatment of inflammatory bowel diseases in Loginov Moscow Clinical Scientific Center from 2019 till 2021 years by surveying 1089 patients with UC. This analysis revealed patients with high adherence (HAP) and low adherence to treatment (LAP).
Results. In the survey analysis was determined, that there were more low-adherence patients, than high-adherence patients [596 (59.6%) and 404 (40.4%), respectively, (р0.001)]. In the group of HAP (100%) were 297 women (73.5%) and 107 (26.5%) men (р0.001). Also in this group prevailed patients with duration of disease more 5 years 305 (75.5%) and extraintestinal manifestations 261 (64.6%); р0.001. In the group of LAP (100%) were more patients younger 44 years, with bad habits and who did not follow diet (р0.001). The rate of UC reccurence more than 1 time per year was higher in LAP group 430 (72.1%), versus 137 (33.9%) patients in HAP (р0.001). The frequency of surgical procedures in UC patients was significantly higher in LAP 12 (2.0%) in comparison with 2 (0.5%) in HAP group (р0.001).
Conclusion. In our study was determined, that among UC patients, examined in the department of inflammatory bowel diseases, 60% patients had low adherence to treatment. High adherence to the treatment is statistically significantly associated with female gender, family accommodation, non-working patients, extraintestinal manifestations, additional medical maintenance. Low adherence to the treatment is associated with steroids, male gender, age less than 44 year, bad habits (smoking, alcohol consumption), higher education, complicated UC and frequency of reccurences.
The risk of developing cardiovascular disease in bipolar disorder. Clinical and social factors
Authors: Mosolov Sergey N. , Fedorova Elizaveta Yu.
Published: January 2022

Bipolar disorder (BD) is one of the most common mental disorders in the world with high mortality and a hard economic burden. Although suicide is the leading cause of death in BD, cardiovascular disease (CVD) also contributes significantly to this rate, the risk of which is seriously underestimated in BD. A sample assessment was made of current studies focusing on the link between BD and CVD. The search was carried out in the PubMed and eLIBRARY databases for the following keywords: bipolar disorder, psychopharmacology, cardiovascular disease, metabolic syndrome. The association between ВD and vascular disease is large. The analysis of adjusted mortality estimates in patients with bipolar disorder showed a significant contribution of CVD. A detailed study of the mutual influence of bipolar disorder BD and CVD is difficult due to the earlier manifestation of BD in comparison with CVD. Most of the studies have focused on cardiovascular risk factors (CVRFs), which are more common in BD than in the general population. Metabolic syndrome (MS) plays a significant role among CVRFs. The reasons for the development of MS in patients with BD are currently not known for sure, however, the instigated factors are certainly a disturbance of the diet, decreased physical activity, pharmacological therapy, and the lack of early preventive and medical care. Patients with hyperuricemia had a higher risk of developing MS. Lifestyle correction and a reduction of CVFRs, as well as the rational use of certain cardiac drugs can improve the better prognosis of the disease and reduce mortality in patients with BD. The predisposition of patients with BD to CVD is undeniable. It is necessary to consider the high frequency of CVRFs in people with BD, and promptly recommend appropriate treatment and special rehabilitation programs for the prevention of CVD complications, considering the change in affective phases and the applied mood-stabilizing drugs.
Functional dyspepsia: a multifaceted problem in gastroenterology
Authors: Osadchuk Mikhail A. , Svistunov Andrei A. , Balashov Dmitrii V. , Osadchuk Maksim M.
Published: January 2022

The article presents the views on dyspepsia in world practice, data on the difficulties of diagnosis and the problem of the effectiveness of various therapy regimens. Particular attention is paid to the use of fixed forms of drugs for functional dyspepsia, in particular Omez DSR.
Ulcerative colitis. To the 180th anniversary of the description by Karl Rokytansky
Authors: Knyazev Oleg V. , Kagramanova Anna V. , Parfenov Asfold I.
Published: January 2022

The article describes the main historical milestones in the description and study of ulcerative colitis from the time of Hippocrates to the present day. The first description of the morphological picture of non-specific ulcerative colitis (NUC) was presented by the Viennese pathologist Karl Rokitansky in 1842. The term "ulcerative colitis" was coined by S. Wilks in 1859. A detailed description of the disease was presented in 1875 by S. Wilks and W. Maxon. In an independent nosological form, NUC was isolated in 1888 by the English doctor White. Boas in 1903. For the first time, he presented the differential diagnosis of NUC and chronic dysentery. The term "non-specific ulcerative colitis" in Russia was first introduced by A.S. Kazachenko in a report at the XIII Congress of Russian Surgeons in 1913.
Аtherosclerosis and cardiovascular risk in patients with inflammatory bowel disease
Authors: Mironova Olga Iu. , Isaikina Mariia A. , Khasieva Sofiia A.
Published: January 2022

Inflammatory bowel disease (IBD) can cause early atherosclerosis. There is a correlation between inflammatory activity in IBD and cardiovascular events. Chronic inflammation can lead to endothelial dysfunction. This review discusses the possibilities of the mechanisms underlying the relationship between IBD and atherosclerosis, the role of innate and humoral immunity, intestinal microbiota, biomarkers (C-reactive protein, homocysteine, etc.), as well as the possibility of early instrumental diagnosis of subclinical manifestations of atherosclerosis in patients with IBD by measuring carotid intimamedia thickness and aortic pulse wave velocity. The need for active prevention of cardiovascular diseases in this group of patients is emphasized, including through the control of inflammation activity, as well as the inclusion of IBD in one of the risk factors for cardiovascular diseases.
The results of phase III multicenter open randomized controlled study REM-Chol-III-16 in patients with intrahepatic cholestasis syndrome caused by chronic diffuse liver diseases
Authors: Stel'makh Viktoriia V. , Kovalenko Aleksey L. , Popova Veronika B. , Uspenskiy Yury P. , Morozov Viacheslav G. , Belikova Tatiana N. , Rafalskiy Vladimir V. , Antonova Elizaveta A.
Published: January 2022

Aim. To assess the safety and efficacy of Remaxol, solution for infusion, compared with parenteral form of S-adenosyl-L-methionine, in the treatment of patients with intrahepatic cholestasis syndrome accompanying chronic diffuse liver diseases of various etiology.
Materials and methods. In a multicenter open-label comparative study of the safety and efficacy of Remaxol (inosine + meglumine + methionine + nicotinamide + succinic acid) 317 patients aged 18 to 65 years were randomized into 2 groups: patients of the experimental group (n=168) received intravenous Remaxol, solution for infusion, 400 ml, and patients of the control group (n=149) Heptral (S-adenosyl-L-methionine) 800 mg. The duration of treatment was 10 days. The primary efficacy endpoint was the proportion of patients who responded to therapy, as demonstrated by dynamics of laboratory parameters of liver functional status: decrease in gamma glutamyl transpeptidase level by 40%, and/or alkaline phosphatase level by 30%, and/or decrease total bilirubin level by 30% from baseline by the end of the treatment course.
Results. The proportion of responders was 51% in the Remaxol group vs. 44.9% in the Heptral group (p=0.303); the lower limit of the one-sided 95% confidence interval for the difference in the proportions of responders was -4.01%, which exceeds the non-inferiority margin pre-defined by the study protocol, thus, the non-inferiority hypothesis was proven, i.e. Remaxol at a dose of 400 ml/day demonstrates similar efficacy to Heptral at a dose of 800 mg/day in patients with intrahepatic cholestasis syndrome associated with chronic diffuse liver diseases. Similar positive trends in the levels of transaminases, total bilirubin and the severity of pruritus were revealed in both treatment groups. We did not reveal statistically significant between-group differences in the frequency of adverse events definitely related to the study treatment.
Conclusion. Administration of Remaxol as a part of the pathogenetic therapy of patients with intrahepatic cholestasis syndrome who need hepatoprotection is justified.
The assessment of renal function during the therapy of arterial hypertension with azilsartan medoxomil in patients with obesity or overweight and concomitant metabolic disorders
Authors: Nevzorova Vera A. , Petrichko Tatiana A. , Chazova Irina E. , Zhernakova Juliya V.
Published: January 2022

Aim. To assess the influence of the therapy of arterial hypertension with azilsartan medoxomil on the renal function in overweight or obese patients with concomitant metabolic disorders. Materials and methods. An international multicenter observational nonintervention prospective study included 1945 patients, taking azilsartan medoxomil in accordance with approved prescribing information. The observation period reached 6 months. Results. In patients with an initial glomerular filtration rate (GFR)60 ml/min/1.73 m2 or 60 ml/min/1.73 m2 mean change in systolic blood pressure after 6 months of therapy reached -32.511.1 and -30.413.6 mmHg, correspondingly, while the change in diastolic blood pressure was -13.78.8 and -14.29.4 mmHg, respectively. No decrease in renal function was observed. Moreover, in patients with an initial GFR60 ml/min/1.73 m2 GFR increased significantly (p0.001). Conclusion. Azilsartan medoxomil, prescribed as monotherapy or in free combinations, provided an effective control of blood pressure in patients with arterial hypertension with both normal or moderately reduced and initially significantly reduced renal function. High efficacy and acceptability of the drug was associated with a beneficial effect on renal function, which allows to consider azilsartan medoxomil as the drug of choice for the treatment of hypertension in patients with concomitant metabolic disorders.
Knowledge of senior students in the definition, classification, and approaches to the treatment of arterial hypertension. Final results of the PHYSTARH project
Authors: Bontsevich Roman A. , Vovk Yana R. , Gavrilova Anna A. , Batishcheva Galina A. , Goncharova Natalia Iu. , Elizarova Irina O. , Ketova Galina G. , Barysheva Valeriya O. , Bikkinina Guzel M. , Myronenko Olena V.
Published: January 2022

Background. Arterial hypertension is a modifiable risk factor for the development of life-threatening cardiovascular complications. Early diagnosis and optimal treatment are the key to success in the fight against this pathology.
Aim. To analyze the knowledge of senior medical students from different regions in the basic issues of hypertension.
Materials and methods. The article presents the results of the first stage of the multicenter PHYSTARH study (the full name of the project is Physicians and undergraduates knowledge in arterial hypertension treatment). An anonymous questionnaire (pharmacoepidemiological survey) was conducted among 314 senior medical students from 6 cities of Russia and Ukraine.
Results. The study revealed the average level of senior students knowledge. The average level of correct answers to the questions in the first part of the questionnaire was 49.4%. The minimum level of correct answers was obtained in the questions of determining hypertension by the value of home blood pressure monitoring, determining the degree of hypertension for a blood pressure of 140/110 mm Hg, the incidence of resistant hypertension, indications for drug correction of high normal blood pressure, the choice of the optimal class of drugs for initial antihypertensive therapy. The maximum level of correct answers was registered only for the question about the definition of hypertension.
Conclusion. The results of the study indicate an insufficiently high level of students basic knowledge in the classification and treatment of hypertension.
The efficiency of two-level electrovectorcardiographic diagnostics of left ventricular hypertrophy in the medical examination of urban and rural population
Authors: Riabykina Galina V. , Vishniakova Nelli A. , Fedorova Valentina S.
Published: January 2022

Background. The incidence of arterial hypertension continues to grow. By 2025 the number of patients will increase to 1.5 billion that makes it necessary to develop and implement effective approaches in the diagnosis and treatment of hypertension in practical health care.

Aim. Evaluate the effectiveness of two-level diagnostics of left ventricular hypertrophy (LVH).

Materials and methods. The distance of the first level of LVH diagnostics in outpatient departments with a territorial is more than 20 km. It was performed by remote electrocardiography, including medical examination of the population. Automatic conclusion of the devices was sent to the personal office of the functional diagnostics doctor. At the second level, the electrocardiograph software was used to convert ECG-12 into a vectorcardiogram (VKG) to clarify LVH. The ECG reports were returned to the device of the doctor/paramedic for further work with the patient. When using scalar ECG criteria for LVH, the most sensitive index was the SokolovLyon index 24.2% of cases, then the Cornell product 19.8% of cases. In the second level of ECG diagnostics, the sensitivity of the method in detecting LVH increased more than 3 times: in terms of the maximum loop vector modulus (M QRS 1.8 mV), 72%, the sensitivity of the total index Rx+Sz (2.7 mV) was 58% of cases, the deviation of the spatial angle QRS-T90 was 42.5%, the spatial area of the loop QRS (S QRSxyz 2.7 mV2), the area of the loop QRS in the horizontal plane (S QRSxz2.2 mV2) 41.5%, the orientation angle of the maximum loop vector t in the horizontal plane (angle Txz70) was detected in 38% of patients. These indicators were found with the same frequency in both groups of examined individuals.

Conclusion. The use of remote two-level ECG and ECG diagnostics allowed to increase the detection of LVH in rural and urban populations by 3 times.
Possibilities of a new glucagon-like peptide-1 receptor agonist Semaglutide in improving left ventricular diastolic function in a patient with arterial hypertension and type 2 diabetes mellitu
Authors: Azimova Makka R. , Zhernakova Julia V.
Published: January 2022

The emergence of new classes of glucose-lowering drugs that can further reduce cardiovascular risk (CVR) have fundamentally changed the approach to the management of patients with type 2 diabetes mellitus. The most significant changes concerned the strategy of choosing glucose-lowering therapy with a change in priorities from the glycemia level to CVR, which plays a key role in choosing a class of antidiabetic drugs. At the same time, the mechanisms responsible for lowering CVR remain largely unclear. Of undoubted interest is the study of effects of a new glucagon-like peptide-1 receptor agonist, Semaglutide, on the preclinical stage of diastolic dysfunction. The article presents a clinical case of the use of Semaglutide in a patient with arterial hypertension and type 2 diabetes mellitus.
lived experiences of teenage girls with scoliosis and the effect of a peer support group, Curvy Girls
Authors: Amja Kristina , Vigouroux Marie , Newman Gillian , Hovey Richard B.
Published: January 2022

CONTEXT: Scoliosis is an abnormal lateral curvature of the spinal column and affects approximately 1% to 3% of adolescents. The relationship between pain and idiopathic scoliosis has not been well documented and remains unclear in the literature. Curvy Girls is an international peer-run support group that aims to reduce scoliosis's emotional impact through education, mutual support, and self-empowerment. 
OBJECTIVES: This study endeavors (1) to gain insight into the lived experience of teenage girls living with scoliosis and (2) to understand how the peer support group, Curvy Girls, has impacted their lives.
APPROACH: We interviewed sixteen members of Curvy Girls living with scoliosis. The interviews were transcribed verbatim, and then interpreted using applied philosophical hermeneutics.
FINDINGS:I. Personal Lens: The narratives of living with undiagnosed pain revealed confusion, solitude, and loneliness. The impact of labeling the pain (i.e., an official diagnosis) led to relief in some cases or irritation in some other cases.
II. Healthcare Lens: The stories of negative healthcare experiences and their impact on teenage girls are uncovered. The teenage girls wanted to be included in treatment decisions that may endorse autonomy and independence during adolescence.
III. Peer support Lens: Curvy Girls provides a safe environment for these adolescent girls to engage. The power of sharing and communicating helps Curvy Girls members cope and feel a sense of belonging. 
SIGNIFICANCE: An insight into these teenage girls’ lived experiences allows for a better understanding of living with scoliosis and how a peer support group can help with this journey.