bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Associated with Longer Length of Stay in Recurrent Cellulitis on Lower Legs
Authors: Brishkoska-Boshkovski Vesna , Vasileva Mirela , Baloski Marjan
Published: October 2020

BACKGROUND: Cellulitis is a common infectious disease with typical feature – the tendency for recurrence.
AIM: The aim of the study was to define comorbidities, clinical, and laboratory – biochemical factors associated with longer length of stay (LOS) in patients with recurrent cellulitis in the lower legs.
MATERIALS AND METHODS: The study is a retrospective-cohort study conducted at the Department of Dermatovenerology at General Hospital in Skopje, from January 2016 to August 2019. In the study, we included and analyzed only hospitalized patients admitted for recurrent cellulitis on the lower legs. Inclusion in the study recorded the following variables – comorbid conditions in the patients – present in the medical records or obtained from the interview of the patient and initial values of laboratory assays on admission.
RESULTS: The study included hospitalized 205 patients, admitted for recurrent cellulitis. The most significant comorbid conditions and laboratory parameters which correlate with increased LOS are as follows: Type 2 diabetes mellitus – insulin dependent (p < 0.001), chronic renal failure (p = 0.003), ischemic heart disease (p = 0.006), peripheral arterial disease (p = 0.007), fever ≥38.0°C (p < 0.001), hypoalbuminemia ˂34 g/L (p < 0.001), elevated value of C-reactive protein >10 mg/L (p < 0.001), and leukocytosis >109 L (p = 0.009).
CONCLUSION: Cellulitis is potential medical emergency event. Recurrence is the most significant complication of cellulitis and lower legs cellulitis is associated with a risk for long-term morbidity. The study has identified several independent factors that are significantly associated with an increased LOS. This independent factors present on admission can stratify the patient with the highest risk of mortality, can improve patient care for better outcomes, and decrease the number of relapses and hospital readmissions.
Smoke-free Zone in Indonesia: Who is Doing What Now
Authors: Sulistiadi Wahyu , Veruswati Meita , Asyary Al , Herawati Maria Holly , Wulandari Ririn Arminsih , Haryanto Budi
Published: October 2020

BACKGROUND: Although all environments whom applied smoke-free zones (SFZs) have sufficient compliance rate (over 80%) in Indonesia particularly in Bogor City, it is still unclear who is doing what now on SFZs activities to assess the effectivity and efficiency of this tobacco control program.
OBJECTIVES: This review aimed to present the evidence of tobacco control on SFZs programs and activities of these zones based on the several indicators set by the local government’s regulation.
MATERIALS AND METHODS: A review was held to observe the SFZs local regulation archives. Data were derived from secondary sources and observation data of law enforcement teams’ generic activities and programs in Bogor City in the Province of Jawa Barat, Indonesia.
RESULTS: There were eight (eight) zones designated as SFZs according to the local regulation, namely: (1) Public places, (2) workplaces, (3) places of worship, (4) children’s playgrounds and/or other gathering places, (5) public transportation, (6) teaching and learning environments, (7) health facilities, and (8) sports facilities. It resulted that 55% of these zones still uncomplied to SFZs regulation. It is still a tobacco control homework in Indonesia while it is remembering that Indonesia has the only largest country of six developing countries that have not ratified Framework Convention on Tobacco Control of the World Health Organization.
CONCLUSION: The role of the SFZs’ enforcement team is crucial and consists of relevant stakeholders to optimize activities and programs of SFZs regulations with clear targeting, rewards, and punishments. However, further studies are needed to determine the effectiveness of non-smoking areas specifically.
Association between Diabetes Consequences and Quality of Life among Patients with Diabetes Mellitus in the Aseer Province of Saudi Arabia
Authors: Alshahrani Sultan M. , Alzahran Moferrah , Alakhali Khaled , Vigneshwaran Easwaran , Iqbal Mir Javid , Khan Noohu Abdulla , Othman Abdullah , Al-Worafi Yaser , Alavudeen Sirajudeen S.
Published: October 2020

BACKGROUND: Diabetes mellitus (DM) is a major health-care burden worldwide.
AIM: The aim of the study was to explore how the quality of life (QoL) of DM patients could be affected in the Aseer Province of the Kingdom of Saudi Arabia (KSA).
METHODS: A cross-sectional, multicenter study in DM patients of both sexes and all age groups in Aseer Province were done using a validated self-administered questionnaire. The study was conducted between April 1, 2018 and November 25, 2018.
RESULTS: A total of 418 patients completed our questionnaire, of which 240 (58%) were male and 178 (42%) were female. Furthermore, 50.23% were married and 104 (24.16%) were illiterate. We found that 403 (96.42%) respondents had type-2 DM and 315 (75.35%) had a family history of DM. In addition, 132 (31.57%) respondents were on monotherapy whereas only 61 (14.59%) were using combination therapy. Hypertension was the most prevalent comorbidity (166, 39.71%) and peripheral neuropathy the most prevalent complication of DM (157, 37.56%).
CONCLUSION: DM had a significant impact on QoL among patients from Aseer Province in KSA. Our study underscores the importance of generating data on QoL among DM patients.
Differences in Spatial Memory Impairment in Mice after Oral D-Galactose Administration and Intraperitoneal Injection
Authors: Widyastuti Ketut , Laksmidewi A. A A.  Putri , Adnyana I Made Oka , Samatra D. P. G. Purwa
Published: October 2020

BACKGROUND: The aging process can increase the incidence of dementia, such as spatial memory impairment to remember space, recognize shapes and distances. Research on dementia in mice was carried out by administering d-galactose through intraperitoneal injection, while oral d-galactose administration had not received enough attention.
AIM: This study aims to prove the differences in the occurrence of spatial memory impairment in rats induced by d-galactose through two different routes, oral and intraperitoneal injection.
METHODS: This study is an experimental study using a post- test control group design. The sample criteria were 20 male Wistar rats aged 12–14 weeks, weighing 200–300 g divided into two groups which are the oral and intraperitoneal injection. Spatial memory assessment based on spontaneous alternation using the Y-maze test was carried out at the end of week 8.
RESULTS: In this study, the average spatial memory score after d-galactose administration in the injection group (51.572±4.388) was lower compared to the oral group (66.058±1.551). The Shapiro–Wilk normality test shows that the data are normally distributed with p > 0.05. Independent t-test showed a significant difference in the incidence of spatial memory disorders between the injection and oral groups with p = 0.010 (p < 0.05).
CONCLUSION: The conclusion of this study is that d-galactose administration by oral route or intraperitoneal injection causes a decrease in spatial memory in mice. Spatial memory in the injection group was lower than in the oral group. This might be related to the decrease in synaptophysin in the hippocampus of mice due to d-galactose administration by intraperitoneal injection.
Anti-receptor Advanced Glycation End Products Decreases Inflammatory Pathways in Retinopathy Diabetics: In vivo Study
Authors: Amin Ramzi , Ansyori A. K. , Erna Riani , Fauzi Lilianty
Published: October 2020

BACKGROUND: Diabetic retinopathy is an emerging microvascular complication of diabetes mellitus and a causes of blindness in individuals between ages 30 and 70 years, which is characterized by increased proliferation of blood vessels, vascular occlusion, angiogenesis, loss of pericytes from retinal capillaries, microaneurysms, retinal bleeding, increased retinal capillary permeability, thickening of capillary basal membranes, and infarcts that affect the retina, induced to permanent blindness.
AIM: This study aimed to find the role of receptor advanced glycation end products (RAGE) inhibition in lowering the vascularization process which causes a decrease in retinal function on diabetic retinopathy.
MATERIALS AND METHODS: This research was an in vivo experimental study. A total of 30 male Wistar rats (200 ± 20 g) were obtained from Eureka Research Laboratory (Palembang, Indonesia). Experimental animals were placed in cages under controlled conditions (12 h of light/dark cycles with temperatures of 22 ± 1°C and humidity of 40–60%), fed and drank ad libitum. White rats were induced by diabetes mellitus using alloxan at a dose of 120 mg/kgBW, intraperitoneally, accompanied by drinking 10% glucose solution for 140 days. Furthermore, experimental animals were grouped into five groups (at eight animals per group), Group 1: Normal control, Group 2: Negative control (induced diabetics retinopathy and given intravenous aquadest), Group 3: Given anti-RAGE 1 ng/mL, Group 4: Given anti-RAGE 10 ng/mL, and Group 5: Given anti-RAGE 100 ng/mL. Giving anti-RAGE was done in a single dosage and intravitreal. After the rats were sacrificed by intraperitoneal injection of 10% chloral hydrate, the evacuation of the eye’s retinal tissue was then carried out, fixed in a 4% paraformaldehyde buffer for immunohistochemistry examination of the eye’s retinal tissue. Evaluation of the expression of nuclear factor-κβ (NF-kB) and intercellular adhesion molecule-1 (ICAM-1) used Image J Software so that the percentage of NF-kB and ICAM-1 expression would be obtained.
RESULTS: Negative control group showed an increase in NF-kB expression in the retinal tissue of diabetic retinopathy rats. Administration of anti-RAGE showed its potential to suppress NF-kB expression in retinal tissue of diabetic retinopathy white rats as well with an increase of anti-RAGE dose from 1 ng/mL to 100 ng/mL. Activation of NF-kB causes activation of the inflammatory cascade, which is characterized by the production of pro-inflammatory cytokines, one of which is ICAM-1. Giving anti-RAGE could suppress the expression of ICAM-1 along with an increase in anti-RAGE dose.
CONCLUSION: Anti-RAGE is able to block the inflammatory process, by inhibiting the expression of NF-kB and ICAM-1 in the retinal tissue of diabetics retinopathy in white rats.
Nonalcoholic Fatty Liver Disease and the Risk of Atrial Fibrillation
Authors: Abou Omar Mahmoud A. , Alaarag Ahmed , Abd-Elsalam Sherief , El-Abgeegy Mohamed , Ahmed Rehab , Mohamed Ahmed Abdelhaleem , Khalil Mahmoud , Abo-Amer Yousry Esam-Eldin , Elkadeem Mahmoud , Yousef Mohamed
Published: October 2020

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is now the factor behind the development of liver cirrhosis, liver cell failure, and liver transplantation in many cases. However, its relation to atrial fibrillation (AF) could not be cleared up.
AIM: The purpose of the study was to evaluate prevalence of AF in the setting of NAFLD; the association between them, and to evaluate risk factors of AF in this category of patients.
METHODS: This cross-sectional study was performed on 400 patients between January 2018 and June 2019. These patients were analyzed for the presence of NAFLD and presence of persistent or chronic AF.
RESULTS: There were 138 patients with NAFLD, and 20 patients with persistent or permanent AF. Factors associated with AF were old age, male gender, and high values of aspartate aminotransferase, alanine-aminotransferase, γ-glutamyltranspeptidase, and serum uric acid. The participants with AF had a significantly greater prevalence of NAFLD than those without AF.
CONCLUSION: Incidence and prevalence of atrial fibrillation in NAFLD patients were high. Severity of liver disease was an important predictor of new-onset atrial fibrillation.
Smart Touch Radiofrequency Catheter Ablation versus Cryoballoon Ablation of Pulmonary Veins in Patients with Paroxysmal Atrial Fibrillation
Authors: Hassan Walid Shehata , Zaky Sherief Hamed , Mohamed Khaled Hussein , Ibrahim Moataz Mohammed
Published: October 2020

AIM: Evaluation of the safety and efficacy of pulmonary veins isolation in patients with paroxysmal atrial fibrillation (AF) using two new different technologies, cryoballoon (CB) ablation and radiofrequency ablation with contact force (CF)-sensing catheters.
METHODS: Prospective single-center evaluation, carried out from January 2016 to June 2018 in Critical Care Medicine Department – Cairo University, comparing CF radiofrequency (Thermocool® SmartTouch, Biosense Webster, Inc.) (CF group) with CB ablation (Arctic Front Advance 28 mm CB, Medtronic, Inc.) (CB group), in regards to procedural safety and efficacy, as well as recurrence at 12 months. Overall, 50 consecutive patients were enrolled (25 in each group).
RESULTS: The characteristics of patients of both the groups were similar (46.9 ± 11.2 years, the proportion of women 36%, mean documented AF duration 3 ± 2.3 years, mean CHA2DS2-VASc score 1.4 ± 1.3, and mean HAS-BLED 1.4 ± 0.6). Duration of the procedure was significantly lower in the CB group (171.7 ± 15.24 vs. 199.3 ± 18.94 min, p = 0.002), with a longer duration of fluoroscopy and X-ray exposure in the CB group than the CF group but statistically non-significant difference (58.60 ± 11.57 vs. 48.7 ± 13.86 min and 6273 ± 4934 cGy cm² vs. 6853 ± 5069 cGy cm², p = 0.1 and p = 0.2, respectively). Overall complication rate was similar in both groups: 2 (8%) in each group. At 12 months, AF recurrence occurred in 7 patients (28%) in the CF group and in 9 patients (36%) in the CB group (log rank p = 0.682).
CONCLUSION: Pulmonary vein isolation using CF-guided RF and second-generation CB leads to comparable single-procedure arrhythmia-free survival at up to 12 months with similar overall complication rate.
Immunohistochemical Expression of Fibroblast Growth Factor Receptor 3 and Cyclooxygenase-2 in Urinary Bladder Carcinomas with Correlation of Schistosomiasis in Egyptian Patients
Authors: Khaled Randa , Gabal Samia , Naem Ahmad
Published: October 2020

BACKGROUND: In Egypt, schistosomal infestation is a leading cause of bladder cancer. A mutation in the fibroblast growth factor receptor 3 (FGFR-3) gene is the most common and most specific genetic abnormality in bladder cancer. Similarly, cyclooxygenase-2 (COX-2) is an inducible, pro-inflammatory enzyme with previous studies showing higher expression in schistosomal-associated bladder cancer.
AIM OF THE STUDY: The aim of the study was to evaluate the immunohistochemical expression of FGFR3 and COX2 in bladder carcinoma and correlates their expression to the associated schistosomal infestation to implicate possible therapeutic treatments.
MATERIALS AND METHODS: This retrospective study included a total of 90 cases of archived, formalin fixed, paraffin-embedded tissue blocks that included variable subtypes and grades of urothelial carcinomas. Immunohistochemistry for expression of FGFR-3 and COX2 was performed using a standard avidin-biotin-peroxidase system.
RESULTS: About 73.3% of the total cases (66 cases) showed variable positive reactivity for FGFR3, of which 33.3% (22 cases) were associated with bilharzia infection. A statistically significant correlation was detected between FGFR-3 and tumor size, grade, histologic subtype, LN status, lymphovascular invasion, and stage. About 83.3% of the total cases (75 cases) showed variable positive immunoreactivity for COX-2, of which 37.3% (28 cases) were bilharzial-associated. A positive correlation was established between COX-2 and grade, concomitant in situ changes and cases associated with bilharzia infection.
CONCLUSION: FGFR-3 can be used as a prognostic marker for low-grade urothelial tumors. Results also portray that COX-2 has an inflammatory inciting role in bladder carcinoma development, especially in patients with a history of schistosomiasis (bilharziasis). Both COX-2 and FGFR-3 should be explored further for its use alone or in combination with conventional treatment, to reduce the recurrence rate and progression of superficial (low grade) tumors.
A Cross-sectional Study on Awareness of Dyslexia Disorder among University Students
Authors: Subramaniyan Vetriselvan , Chun Ng Kah , Shahrudin Puteri Nurkhalilah Huda bt , Singh Deshvinderjit Singh A/L Dalvindar , Sivanadam Gasthuri A/P , Qi Low Pei , Ahamed Mohamed Moosa Musthak , Priya Ramasamy Ravi Roshini , Zahir Riuman Mohamed , Santhi Vijayalekshmi Kumar , Seng Wu Yuan , Kumarasamy Vinoth , Fuloria Neeraj Kumar , Fuloria Shivkanya
Published: October 2020

BACKGROUND: The condition of dyslexia is a learning disability leading to difficulty in acquiring basic skills of reading, spelling, and writing. It is a disorder with a neurological origin that does not affect the intelligence of a person. It is estimated that between 5% and 10% of the population suffering from dyslexia, but this number can also be as high as 17% because dyslexia may not be recognized and diagnosed in some individuals and because some of them may not disclose that they are diagnosed. In Malaysia, it is estimated that 4% to 8% of children attending school have dyslexia. Dyslexics tend to be more artistic and creative than others.
AIM: This study examines the awareness of dyslexia disorder among university students.
METHODS: The data are collected from the participants through self-made survey questionnaires that consist of 25 questions per questionnaire. A descriptive cross-sectional study is conducted from April 2019 to May 2019.
RESULTS: The current study reflected that dyslexia, not a disease, thus it is not curable. Individuals with dyslexia require extra patience and effort from the family members, teachers, as well as the public, especially in their learning process. We believe that a lack of understanding about this disorder by the public will bring negative impacts to dyslexic individuals such as causing unwanted misunderstanding, causing mental stress to the dyslexics, bringing negative impact to their learning processes, and so on.
CONCLUSION: Our study results suggest that the knowledge level of dyslexia among university students considered as lower than average.
Erythrocyte Formation Rate in Wistar Anemia Induced 2,4-Dinitrophenylhydrazine through Intake Maize Biofortified Iron
Authors: Muhammadong Jumadi , Sirajuddin Saifuddin , Djide M. Natsir , Mallongi Anwar
Published: October 2020

BACKGROUND: Biofortification through Pseudomonas putida IFO 14796 intervention has succeeded to improve iron content in maize grain up to 18.79%.
AIM: This study was carried out to assess the effect intake of maize biofortified iron (MBI) on the red blood cell (RBC) formation rate in Wistar rat anemia induced 2,4 dinitrophenylhydrazine.
METHODS: Randomized complete design was carried out to assess the effect of MBI on the erythrocyte level with four levels of MBI treatment (R1=10%; R2=12%; R3=14%, and R4=16% of rat body weight [BW]) and one of control (Ro=10% maize non-biofortified iron), and five replications, respectively. Erythrocyte level was measured using the Counting Neubauer Chamber Method after Wistar anemia induced 2,4-dinitrophenylhydrazine (DPNH) after intake MBI for 7 days. Data were analyzed by ANOVA and Fisher’s least significant difference.
RESULTS: There was an influence intake of MBI level on the improving rate the erythrocyte formation in Wistar anemia (p < 0.05). Treatment R1 improved to 0.058±0.034% significantly different with R0 (0.006±0.017%), but non-significantly with R2 and R4 at p < 0.05. Linear regression showed the equation, y=−0.002x+0.07; R2=0.69.
CONCLUSION: Intake MBI more than 10% BW negatively effect to RBC formation rate of Wistar rat’s anemia.
Laundry washing increases dispersal efficiency of cloth-dispersed propagules
Authors: Valkó Orsolya , Lukács Katalin , Deák Balázs , Kiss Réka , Miglécz Tamás , Tóth Katalin , Tóth Ágnes , Godó Laura , Radócz Szilvia , Sonkoly Judit , Kelemen András , Tóthmérész Bela
Published: October 2020

Due to increased human mobility, cloth-dispersed propagules can be transported over long distances, which would not have been bridged otherwise. We studied a potentially important component of human-mediated seed dispersal by assessing the effects of laundry washing on the dispersed propagules. We studied the germination of 18 species, which have morphological adaptations for epizoochory and are commonly dispersed by people. We tested six treatments (washing with water, soap nut or detergent, at 30 °C or 60 °C) compared to an untreated control. Washing intensity was the most significant factor affecting germination. Washing at 30 °C was neutral for 14 species, suppressed one species and supported three species. Washing at 60 °C decreased seedling numbers of half of the studied species. The intensive washing treatments at 60 °C significantly decreased the synchrony of germination. We showed that people are not purely transporting propagules from one location to another, but via the laundry cycle, we can also influence the fate of the transported propagules by affecting germination potential, seedling fitness and germination dynamics. These results have new implications for understanding the early stages of biological invasions and call for improved biosecurity measures in nature reserves subjected to a growing pressure of tourism.
A geranylated chalcone with antiplatelet activity from the leaves of breadfruit (Artocarpus altilis)
Authors: Fakhrudin Nanang , Pertiwi Krisna Kharisma , Takubessi Marce Inggrita , Susiani Eka Fitri , Nurrochmad Arief , Widyarini Sitarina , Sudarmanto Ari , Nugroho Arief Adi , Wahyuono Subagus
Published: October 2020

Platelet plays a crucial role in cardiovascular diseases (CVDs) development. Abnormalities in platelet aggregation provokes thromboembolism, eventually leading to death. In Indonesia, breadfruit (Artocarpus altilis) leaf is traditionally used to treat CVDs. This study aimed to evaluate the antiplatelet activity of A. altilis leaf extract (AAE) and to identify its active compound. A. altilis leaves were extracted with ethanol, and the antiplatelet activity was assessed using ADP-induced platelet aggregation. The major compound was isolated with column chromatography followed by preparative TLC, and the structure was determined on the basis of UV, MS, IR, and NMR spectra. The binding mode of the active compound to platelet receptors was characterized in in silico study. AAE exhibited an antiplatelet activity (IC50 of 252.23 µg/mL). A geranylated chalcone, 2-geranyl-2ʹ,3,3,4ʹ-tetrahydroxydihydrochalcone (GTDC) was identified as the antiplatelet compound (IC50 of 9.09 µM). GTDC actions with P2Y12 platelet receptor involving three amino acid residues.
Pourquoi Vincent a-t-il moins de chances d’obtenir un logement qu’Émilie ? Une analyse des causes de la discrimination à l’égard des noms masculins
Authors: Flage Alexandre
Published: October 2020

Dans cet article, nous avons étudié l’ampleur et surtout les causes de la discrimination à l’encontre des candidats masculins lors de la première étape du processus de location (à savoir lorsque les individus demandent à visiter l’appartement) par l’intermédiaire d’une méta-analyse de 23 tests de correspondance réalisés dans 15 pays de l’OCDE et représentant un total de 110 000 emails envoyés à des propriétaires ou à des agents immobiliers. Les noms féminins ont 13 % de chances de plus que les noms masculins d’obtenir une réponse positive de la part des agents et ce résultat est invariablement présent dans les pays de l’OCDE. Les candidats féminins semblent cependant faire face à une discrimination statistique de premier ordre concernant leur stabilité financière, mais cet effet négatif est plus que compensé par une discrimination statistique subie par les candidats masculins en raison de leur comportement perçu comme plus à risque. Enfin, il semblerait que le traitement différentiel entre les hommes et les femmes ne soit pas significativement plus élevé pour les individus ayant un nom à consonance étrangère que pour les individus ayant un nom typique du pays testé.
Čarovništvo – diskurz ali praksa?
Authors: Mencej Mirjam
Published: October 2020

This paper challenges a generally accepted view that witchcraft is always a matter of discourse, and the witch a fictitious person who is ascribed bewitchment but, in fact, performed none. It discusses the hints that point to bewitchments being, at least occasionally, a matter of practice and reality, and a “witch” indeed a practitioner of acts, perceived as harmful. It also challenges the etic difference between the “natural” and “supernatural” acts in the context of witchcraft accusations and argues that there is no clear difference between the former and the latter for people thinking within a witchcraft discourse.
“Petishism”, or Animals in the City and on the Islands: Case Study of the Island of Silba
Authors: Marjanić Suzana , Ratkovčić Rosana
Published: October 2020

The first part of this paper (by Suzana Marjanić) documents the fact that city authorities throughout Croatia do not encourage needed care for stray dogs and cats, specifically the construction of state and private shelters for abandoned and lost animals, as well as feeding stations. Zagreb, the capital of Croatia, does not have a shelter for cats. Also documented are exhibitions of animal studies in Croatia, two of which were organised in Zagreb in the same year: an artistic one All Our Animals – Animals as Subjects in Croatian Modern Fine Arts (Modern Gallery, Zagreb, 2017), and another from the aspect of ethnozoology and anthropology of animals – Of Animals and Humans (Ethnographic Museum, Zagreb, 2017), both of which also featured cats.The second part of the article (by Rosana Ratkovčić) notes the fact that the number of stray cats on Croatian islands increases each year, as pets brought by tourists are frequently left behind at the end of summer vacation. On the example of the island of Silba and its only (eponymous) town, how the local population has self-organised the protection of the island’s stray cats is presented.
Saberes locales en huertas de montaña del sur de los Andes: un refugio de memoria biocultural mapuche pewenche
Authors: Marchant Santiago Carla , Fuentes Acuña Nicolás , Kaulen Luks Santiago , Tomás Ibarra José
Published: October 2020

Las huertas de montaña son sistemas socio-ecológicos clave para la producción agrícola destinada al consumo familiar. El cuidado y gestión de ellas recae principalmente en manos de mujeres que desarrollan diversas prácticas agrícolas que han aprendido y cultivado gracias a la transmisión de los saberes locales. Con un enfoque metodológico mixto, que incluyó fichas de caracterización predial, entrevistas semiestructuradas y grupos focales, este trabajo recopiló y sistematizó los principales saberes locales, asociados a conocimientos, prácticas y creencias, de un grupo de mujeres mapuche pewenche en una comuna cordillerana del sur de Chile. Los resultados permitieron distinguir tres categorías de saberes asociados al manejo de la huerta: i) control de organismos patógenos, ii) manejo y fertilidad del suelo, y iii) diseño y gestión de sistemas productivos. Estos saberes participan en la construcción de una memoria biocultural asociada a la huerta que ha perdurado en el tiempo y se ha transmitido entre generaciones. Evocar esta memoria permite mantener vivo el pasado, comprender el presente y planificar de manera sustentable el futuro de la agricultura a pequeña escala en territorio ancestral mapuche pewenche del sur de los Andes.
Oraciones finales en hebreo rabínico
Authors: Pérez Fernández Miguel
Published: October 2020

Dentro del Corpus Tannaiticum y tomando como punto de partida el texto de Sanh 4,5, se estudian distintos tipos de oración final: lě- + infinitivo, še- con valor final y exegético, el uso de bišḇil še- en oraciones nominales y verbales, valor y uso de kěḏê lě- y kěḏê še-, y origen y uso de šemma’.
Aspectos del Sefer ha-galuy de Yosef Qimḥi
Authors: Sáenz-Badillos Ángel , Targarona Judit
Published: October 2020

El Sefer ha-galuy, escrito por Yosef Qimḥi hacia 1165, es en cierto modo una continuación de la polémica filológica que comenzara en el s. X en Córdoba, y una muestra del eco que ésta tuvo en la Europa del s. XII. El nombre de la obra indica que el autor trata de "descubrir o desvelar" dónde está la verdad en cada cuestión debatida por Dunaš y Měnaḥem, y, en su caso, por Rabbenu Tam. En este trabajo se analiza el único manuscrito en el que se conserva la obra y el procedimiento seguido por Yosef Qimḥi en su toma de postura ante la disputa clásica, y en sus críticas personales al Maḥbereṯ de Měnaḥem ben Saruq. Enlazando con la más pura tradición sefardí, ofrece una aportación muy positiva a la discusión filológica desde un análisis lingüístico riguroso y el dominio de los avances logrados por los filólogos andalusies del s. XI.
Flavio Josefo. Técnicas de adaptación del texto bíblico (1 Re 3, 16-28)
Authors: Spottorno M.ª Victoria
Published: October 2020

Las técnicas que emplea Flavio Josefo para adaptar el texto de la Biblia están reflejadas en esta unidad narrativa del juicio de Salomón. Es un buen ejemplo de cómo utiliza sus fuentes incorporando los datos históricos y apartándose del léxico y estilo del relato bíblico.
El payṭan R. Isaac de Castellón
Authors: Del Valle C.
Published: October 2020

Edición y traducción castellana de un piyyût de R. Isaac de Castellón (s. XIII), según el Ms. Add. 14.761 de la British Library. El poema suministra una base para conocer mejor a R. Isaac de Castellón y sus técnicas poéticas.
Vocablos griegos y latinos en el Targum de Lamentaciones
Authors: Alarcón Sainz Juan José
Published: October 2020

Este artículo contiene el análisis de todos los términos de origen griego y latino que he podido localizar, salvo error u omisión, en el TgLam (Ms. 110 de la Biblioteca Nacional de Paris). En la realización del trabajo he consultado las obras lexicográficas de Levy, Jastrow, Krauss y Sokoloff (para el significado arameo), así como las de Liddell/Scott (para el griego) y Glare (para el latin).
El testimonio textual de la Políglota Complutense para la edición del texto luciánico en 3 y 4 Reyes
Authors: Busto Saiz José Ramón
Published: October 2020

De la colación íntegra del texto griego de la Políglota Complutense en 3 y 4 Reyes para la edición crítica del texto antioqueno en esos libros, se deduce que dicho texto sigue habitualmente el del ms. Vat. Gr. 330 (= Verzeichnis 108). Constituye, sin embargo, una nueva recensión, porque el texto ha sido reordenado, desde un punto de vista literario, de acuerdo con el texto hebreo, como señaló Rahlfs. También se comprueba, contra Rahlfs, que los editores complutenses no actuaron de manera arbitraria. De ello se deduce que el testimonio de la Complutense no es útil para la edición del texto antioqueno, ya que su testimonio luciánico es sencillamente el del ms. 108.
Ecl 12,1-7 interpretado por Abraham ibn ‛Ezra
Authors: Gómez Aranda Mariano
Published: October 2020

La interpretación alegórica de Ecl 12,1-7, que aparece en el Talmud, en los midrašîm y en algunos comentarios bíblicos explica este pasaje como la decrepitud del hombre al final de su vida y la descomposición del cuerpo después de la muerte. Ibn ‛Ezra adopta algunas de estas interpretaciones, pero, utilizando sus conocimientos exegéticos y las normas de la gramática hebrea, refleja la teoría neoplatónica, presente en otras obras suyas, de que el espíritu del hombre en el momento de la muerte deja de realizar sus funciones sobre el cuerpo y asciende hacia Dios, mientras el cuerpo se descompone en la tumba.
Una escritura de compromiso de otorgar la ḥalîṣâ
Authors: Lacave José Luis
Published: October 2020

Entre los documentos hebreos hallados en el Archivo Municipal de Tudela hace 1O años, figura, en un apéndice a una Kětûbbâ, el documento que aquí se publica, por el cual un posible futuro yabam, en el momento de la boda de su hermano, se compromete a otorgar la ḥalîṣâ a la yěbamâ cuando se diera el caso. No era esto habitual en España, pero sí en Francia, y aunque el documento está fechado en Tudela, el yabam, Mošeh de Narbona, y su familia eran de origen francés.
Acaeceres en la vida de Juce Gotina, sastre judío de la villa de Épila (siglo XV)
Authors: Marín Padilla Encarnación
Published: October 2020

Este estudio comenta algunos aspectos de la vida de Juce Gotina, sastre judío que residió en Épila, villa aragonesa del señorío de los Ximénez de Urrca, en el siglo XV. Juce fue hijo de Jaco Gotina y nieto del judío zaragozano Nahamen Gotina y de Estruga Albala.
‘Erigir una estatua’ en las antiguas dedicaciones arameas
Authors: Martínez Borobio Emiliano
Published: October 2020

El análisis de las frases principales de las dedicaciones de estatuas en el arameo antiguo nos hace ver que ya en el s. IX a. C. Existían unos esquemas propios arameos frente a los asirios, como demuestra una comparación de los textos asirio y arameo de la estatua de Hadyiṯ‛i de Tell Fekherye. Dentro de estos esquemas arameos resalta el uso de šm [śym] qdm y šm l-, seguidos del nombre divino o de persona, y que deben de indicar dos situaciones diferentes en cuanto a la dedicación de una estatua dentro o no de un templo. Por otro lado, tenemos atestiguados como verbos principales, que crean esquemas paralelos de dedicación, los verbos šym, kwn, yhb, qwm, siendo el verbo šym el usado casi exclusivamente, en tanto que qwm sólo se encuentra atestiguado una sola vez, situación que contrasta sorprendentemente con el empleo casi exclusivo de qwm en dedicaciones de estatuas en el arameo posterior: el bíblico y el de Hatra y Palmira, donde no encontramos nunca šym.
Una kěṯûbbâ de Jaca
Authors: Lacave José Luis
Published: October 2020

Hace unos años David Romano publicaba una lista nominal de 115 contribuyentes judíos de Jaca en 1377. El autor edita ahora una kěṯûbbâ de Jaca de 1429, que, en cierto modo, le sirve de complemento. Separados ambos documentos por el crucial año 1391, se observa, sin embargo, que en la ciudad aragonesa se mantuvo en el siglo XV el mismo núcleo de familias del siglo XIV.
De 1390 a 1420, le roi Charles III de Navarre protecteur des juifs étrangers a son royaume
Authors: Leroy Béatrice
Published: October 2020

El rey de Navarra Carlos III, como manifestación de su independencia y de su política individual, acogía en su reino a judíos extranjeros. En los años 1401-1402 recibió en Sangüesa a Hasdai Crescas, de Zaragoza, para tratar del asentamiento en Tudela de varias familias judías procedentes de aquella ciudad. El rey invitó también al Maestre Ezdra Alazar, físico de Zaragoza, manteniendo a su servicio al médico Josef ben Wakkar de Castilla. Este hecho se explica por la política de Carlos III de proteger las aljamas y dar cargos de responsabilidad a la elite de los judíos, al mismo tiempo que les invitaba a convertirse.
Uma incursão ao Baixo Rio Branco (Roraima/Amazonas), saneamento básico
Authors: Veras Antonio Tolrino de Rezende , Ribeiro Wagner Costa , Santos Eder Rodrigues
Published: October 2020

Este texto relata atividade de campo realizada no mês de maio, entre os dias 15 a 30 de 2019, relacionadas ao projeto: Estratégias de Ordenamento Territorial em Comunidades de Interesse Socioambiental na Amazônia. O objetivo central dessa etapa da pesquisa foi avaliar as estratégias de ordenamento territorial e socioambiental na Amazônia com ênfase no estado de Roraima.
Conservacionismo y nuevos usos del suelo en el Bajo Amazonas y en la Norpatagonia chilena: una discusión sobre renta territorial y vocación espacial en el contexto del capitalismo contemporáneo
Authors: Matheus Luis Fernando De , Cornetta Andrei
Published: October 2020

Este artículo tiene por objetivo discutir teóricamente algunos de los desdoblamientos geográficos relacionados a los procesos de conversión de la naturaleza conservada y del paisaje en mercancías, cuyo valor se constituye a partir de una relación contradictoria entre escasez y rareza. Entendemos esta relación como parte de un proceso que potencializa y diversifica las diferentes formas de extraer renta territorial, promoviendo cambios considerables en la vocación espacial de determinados lugares. Siendo capital potencial, el espacio conservado es una reserva de valor que se expande en relación directa con sus posibilidades de uso. En esta ocasión debatimos este proceso de resignificación territorial, poniendo énfasis en develar cómo las prácticas y los discursos construidos en torno al conservacionismo vienen impulsado o modificando la conformación de nuevas formas de renta territorial. A partir de una perspectiva teórica crítica, y de las observaciones surgidas de nuestras respectivas investigaciones en la Amazonia brasileña y en la Norpatagonia chilena, tratamos de avanzar algunas cuestiones acerca del proceso que ha renovado y complejizado las formas de extraer renta territorial en ambas regiones, cargadas de diversidad y simbologías particulares. Aunque esas regiones tengan enormes diferencias históricas y geográficas entre sí, ambas constituyen casos bastante representativos de cómo por medio del discurso y de las prácticas conservacionistas, el capital viene logrando reproducirse en el espacio rural sudamericano en la actualidad.
Avaliação da sensibilidade dos parâmetros do modelo de simulação de deslizamentos SINMAP
Authors: Bueno Karen Estefania Moura , Schultz Gilson Bauer , Santos Irani dos
Published: October 2020

Este trabalho apresenta a avaliação da sensibilidade dos parâmetros e a descrição dos mecanismos da geração de deslizamentos translacionais utilizando o modelo SINMAP (Stability INdex MAPping). Este modelo simula as áreas de instabilidade de encostas passíveis à ocorrência de deslizamentos translacionais com base em uma variação da equação do fator de segurança (FS), que leva em consideração a razão entre as forças estabilizantes e desestabilizantes do terreno para análise do equilíbrio limite do sistema. A área de estudo é a bacia do Rio Sagrado, localizada na Serra do Mar Paranaense, a qual apresenta vertentes com alta susceptibilidade à ocorrência de deslizamentos. A metodologia empregada consistiu no teste do desempenho do modelo em relação à diferentes resoluções do Modelo Digital do Terreno (MDT) e na análise da sensibilidade dos parâmetros: ângulo de atrito interno do solo, T/R e coesão adimensional do solo; por meio intervalos de valores estabelecidos a partir da calibração do modelo. Os resultados permitiram constatar que a melhor resolução do MDT para simulações com o SINMAP na bacia do rio Sagrado é a da 10m, e que o parâmetro de maior sensibilidade é a coesão adimensional, o qual influenciou de maneira significativa os resultados do modelo.
The Impact of Political Trust on E-Government Services Adoption
Authors: Mensah Isaac Kofi
Published: October 2020

This study explored the impact of political trust on the adoption of e-government services in China. The data for this study was generated through a research questionnaire instrument. The technology acceptance model (TAM) was used as the theoretical framework for the study while the analysis was done with SPSS. The results indicated that political trust is a significant predictor of the intention to use e-government services. The results also demonstrated that whilst political trust was not significant in predicting the perceived usefulness of e-government services, it was significant in determining the perceived ease of use of e-government services. In addition, this study has shown that political trust has a significant moderating effect on both the impact of perceived usefulness and perceived ease of use on the intention to use e-government services. The implications of these findings are discussed.
The role of Protopine associated with Nuciferine in controlling adverse events during hyperthermic intravesical chemotherapy instillations. A nutraceutical approach to control adverse event during intravesical instillations
Authors: Chiancone Francesco , Carrino Maurizio , Fedelini Maurizio , Fabiano Marco , Persico Francesco , Meccariello Clemente , Fedelini Paolo
Published: October 2020

Objectives: The aim of this study was to analyse the role of two alkaloid, Protopine and Nuciferine, in the prevention and the treatment of the low and mild grade adverse events related to the use of HIVEC® (Hyperthermic IntraVEsical Chemotherapy) instillations. Materials and methods: From September 2017 to September 2019, 100 patients were prospectively randomized into two groups: Group A = Protopine and Nuciferine syrup, 10 ml, once a day, for 8 weeks; Group B = placebo (flavoured coloured water), 10 ml, once a day, for 8 weeks. The primary endpoint was the evaluation of the efficacy of the therapy with Protopine and Nuciferine in controlling of the irritative symptoms. The secondary endpoint was the evaluation of the influences of the treatment on the uroflowmetric parameters. Results: The patients of Group A showed a better International Prostatic Symptoms Score (IPSS) score, a better control of urgency symptoms (PPIUS) and tolerate well the pain (VAS score). The treatment doesn’t modify Uroflow-Qmax and seems to improve the Uroflow-Voided Volume (ml) without influencing the Uroflow-Post Void Residual volume (PVR). Moreover, the treatment with Protopine and Nuciferine has been proven to be effective in the treatment of overactive bladder (OAB) symptoms. Patients’ evaluation of the two different treatments assessed with Patient Global Impression of Improvement questionnaire (PGI-I), demonstrated improvements in the Group A, while the Group B showed a lower satisfaction.Conclusions: Protopine and Nuciferine can be interesting nutraceutical compounds useful to control irritative and pain related symptoms of intravesical chemo/immunotherapy.
Expression of miR-132 and miR-212 in prostate cancer and metastatic lymph node: Case report and revision of the literature
Authors: Salemi Michele , Pettinato Angela , Fraggetta Filippo , Calogero Aldo E. , Pennisi Michele , Pepe Ludovica , Pepe Pietro
Published: October 2020

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that act as key regulators in various physiological and pathological processes as prostate cancer (PCa). In this study we describe molecular evaluation of 132 and 212 miRNAs expression, by Real-time reverse-transcription PCR (qRT-PCR), in a Caucasian man 64-year-old with locally advanced PCa (PSA 160 ng/ml, Gleason score 4+3/ISUP Grade Group 3, clinical stage T3NXM0) who underwent radical retropubic prostatectomy plus extended pelvic lymphadenectomy (LAD) as first step of a multimodal therapeutic treatment. A normal prostate of a 67-year-old man removed by post mortem autopsy was used as a control in the study. The mRNA for this study was conducted on paraffined prostatic sections of: a) index case of PCa; b) metastatic lymph node of index case; c) normal prostate. MiRNA-132, miRNA- 212 and Glyceraldehyde 3-phosphate dehydrogenase (as reference gene) assays were obtained. Definitive specimen showed a pT3bN1R1 stage: acinar cells adenocarcinoma with involvement of the seminal vesicles, multifocal positive surgical margins, Gleason score 8 (4+4/ISUP Grade Group 4), metastases in 5/25 iliac lymph nodes. An increased expression of miRNA-132 and miRNA-212 in index case of prostatic adenocarcinoma compared to normal prostate tissue was found; moreover, a lower expression of miR-132 and miR-212 in metastatic lymph node compared to primitive PCa and normal prostate tissue was demonstrated. Although a greater number of patients should be evaluated, these data suggest that the biology of the primary PCa, in our clinical case, was different from metastatic lymph node.
Fatal infections in andrology. Atypical clinical presentation of a Fournier’s disease
Authors: Olivieri Valerio , Ruggiero Gabriele , Abate Danilo , Serra Nicoletta , Fortunati Valentina , Griffa Daniele , Forte Flavio , Corongiu Emanuele
Published: October 2020

Background: Fournier disease (FD) is a worrisome infection of genital area caused by a polimicrobial infection and characterized by a rapid progression to necrosis. Scrotum, perineum and lower abdomen represent the primary sites of origin. Clinical presentation and laboratory strongly suggest FD, but if not precociously diagnosed, it may quickly evolve into septic syndrome and patient’s death. Case report: A 62 years old Caucasian male presented for fever and penile gross oedema recently occurred. No history of previous urinary tract infection, hematuria or genital trauma was referred. He did not complain any storage or voiding low urinary tract symptom (LUTS); no foci of infection in genitoperineal area was observed nor urethral discharge. The ultrasound (US) revealed a disomogeneous broad thickening of subcutaneous tissues with increased vascularity on Color-Doppler. When the penis was manipulated in order to reduce oedema, retract foreskin and evaluate the glans, clinical parametres rapidly worsened and the patient developed a septic shock with blood pressure falling down, dyspnoea and tachyarrhythmia, and he was fastly sent to Intensive Care Unit where it has been hemodynamically stabilized and subjected to antibiotic therapy. Considering the clinical absence of gangrene’s foci, we opted for a conservative treatment by maintaining bladder catheter and drug therapy.
Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance?
Authors: Bernardino Rui Miguel , Carvalho Rita , Severo Luis , Alves Marta , Papoila Ana Luisa , Pinheiro Luis Campos
Published: October 2020

Introduction: Following the 2014 International Society of Urological Pathology meeting, a rapidly growing body of evidence by several researchers has been demonstrating a poor prognosis in association with cribriform morphology. The aim of our study was to describe the presence of cribriform foci in specimens of radical prostatectomies and to evaluate whether demographic and clinical characteristics are associated with the presence of cribriform pattern. Materials and methods: This cohort study was based on 70 radical retropubic prostatectomies specimens collected between 2012 and 2016 and evaluated for the association of the cribriform pattern with age, prostate-specific antigen at surgery day, Gleason on biopsy, Gleason after radical prostatectomy, extracapsular extension, vesicles invasion, margins, multiparametric magnetic resonance imaging, and post-operative radiotherapy. Results; From the univariable analysis, biochemical prostatespecific antigen recurrence (p = 0.001), extracapsular extension (p = 0.003), pre-operative prostate-specific antigen (p = 0.017), vesicles invasion, (p = 0.038) and post-operative radiotherapy (p < 0.001) showed an association with the presence of cribriform pattern. There was also a significant difference of cribriform pattern and Gleason 7 in needle biopsy (p = 0.020) and cribriform pattern and Gleason 8 or 9 in radical prostatectomy specimen (p = 0.036). Conclusions: In our study, the increase in preoperative prostate-specific antigen had a high association with cribriform pattern. Further evidence is needed to discriminate preoperative prostate specific antigen values that might potentially be associated with the presence of cribriform pattern. Raising our knowledge about the cribriform pattern can be an excellent opportunity to correctly identify and treat patients who will eventually die from prostate cancer, sparing treatment in those who will not.