bluuebunny/crossref_metadata_2025 huggingface dataset:
BODIPYs in PDT: A Journey through the Most Interesting Molecules Produced in the Last 10 Years
Authors: Malacarne Miryam Chiara , Gariboldi Marzia Bruna , Caruso Enrico
Published: September 2022

Over the past 30 years, photodynamic therapy (PDT) has shown great development. In the clinical setting the few approved molecules belong almost exclusively to the porphyrin family; but in the scientific field, in recent years many researchers have been interested in other families of photosensitizers, among which BODIPY has shown particular interest. BODIPY is the acronym for 4,4-difluoro-4-bora-3a, 4a-diaza-s-indacene, and is a family of molecules well-known for their properties in the field of imaging. In order for these molecules to be used in PDT, a structural modification is necessary which involves the introduction of heavy atoms, such as bromine and iodine, in the beta positions of the pyrrole ring; this change favors the intersystem crossing, and increases the 1O2 yield. This mini review focused on a series of structural changes made to BODIPYs to further increase 1O2 production and bioavailability by improving cell targeting or photoactivity efficiency.
Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration
Authors: Dahlke Eileen , Engmann Toni , Anan Yaman , Häsler Robert , Solinas Giovanni , Theilig Franziska
Published: September 2022

Acute kidney injury (AKI) is a common renal injury leading to relevant morbidity and mortality worldwide. Most of the clinical cases of AKI are caused by ischemia reperfusion (I/R) injury with renal ischemia injury followed by reperfusion injury and activation of the innate immune response converging to NF-ĸB pathway induction. Despite the clear role of NF-ĸB in inflammation, it has recently been acknowledged that NF-ĸB may impact other cell functions. To identify NF-ĸB function with respect to metabolism, vascular function and oxidative stress after I/R injury and to decipher in detail the underlying mechanism, we generated a transgenic mouse model with targeted deletion of IKKβ along the tubule and applied I/R injury followed by its analysis after 2 and 14 days after I/R injury. Tubular IKKβ deletion ameliorated renal function and reduced tissue damage. RNAseq data together with immunohistochemical, biochemical and morphometric analysis demonstrated an ameliorated vascular organization and mRNA expression profile for increased angiogenesis in mice with tubular IKKβ deletion at 2 days after I/R injury. RNAseq and protein analysis indicate an ameliorated metabolism, oxidative species handling and timely-adapted cell proliferation and apoptosis as well as reduced fibrosis in mice with tubular IKKβ deletion at 14 days after I/R injury. In conclusion, mice with tubular IKKβ deletion upon I/R injury display improved renal function and reduced tissue damage and fibrosis in association with improved vascularization, metabolism, reactive species disposal and fine-tuned cell proliferation.
Density Functional Theory Study of Low-Dimensional (2D, 1D, 0D) Boron Nitride Nanomaterials Catalyzing Acetylene Acetate Reaction
Authors: Zhang Xunchao , Kang Lihua , Zhu Mingyuan
Published: September 2022

In this paper, density functional theory (DFT) was used to study the possibility of low-dimensional (2D, 1D, 0D) boron nitride nanomaterials to catalyze acetylene acetate reaction, and further explore the possible source of this catalytic activity. It is found that the catalytic activity of boron nitride nanomaterials for acetylene acetate reaction will change with the change of the geometric structure (dimension) and reaction site of the catalyst. From the geometric structure, the reaction components and the zero-dimensional BN catalyst can form chemical bonds and form complexes, while only physical adsorption occurs on the surface of the one-dimensional and two-dimensional BN catalysts. From the reaction site, the properties of different C sites on the B12N12NC-C2H2 complexes are different. Namely, a C atom connected with a B atom is more likely to have an electrophilic reaction with H+, and a C atom connected with an N atom is more likely to have a nucleophilic reaction with CH3COO−. Through the study of three kinds of BN nanomaterials with low dimensions, we found that the zero-dimensional B12N12 nanocage broke the inherent reaction inertia of BN materials and showed good catalytic activity in an acetylene acetate reaction, which is very likely to be a non-metallic catalyst for the acetylene gas-phase preparation of vinyl acetate.
Transcriptome Analysis Reveals Critical Genes and Pathways in Carbon Metabolism and Ribosome Biogenesis in Poplar Fertilized with Glutamine
Authors: Han Mei , Xu Mingyue , Su Tao , Wang Shizhen , Wu Liangdan , Feng Junhu , Ding Changjun
Published: September 2022

Exogenous Gln as a single N source has been shown to exert similar roles to the inorganic N in poplar ‘Nanlin895′ in terms of growth performance, yet the underlying molecular mechanism remains unclear. Herein, transcriptome analyses of both shoots (L) and roots (R) of poplar ‘Nanlin895’ fertilized with Gln (G) or the inorganic N (control, C) were performed. Compared with the control, 3109 differentially expressed genes (DEGs) and 5071 DEGs were detected in the GL and GR libraries, respectively. In the shoots, Gln treatment resulted in downregulation of a large number of ribosomal genes but significant induction of many starch and sucrose metabolism genes, demonstrating that poplars tend to distribute more energy to sugar metabolism rather than ribosome biosynthesis when fertilized with Gln-N. By contrast, in the roots, most of the DEGs were annotated to carbon metabolism, glycolysis/gluconeogenesis and phenylpropanoid biosynthesis, suggesting that apart from N metabolism, exogenous Gln has an important role in regulating the redistribution of carbon resources and secondary metabolites. Therefore, it can be proposed that the promotion impact of Gln on poplar growth and photosynthesis may result from the improvement of both carbon and N allocation, accompanied by an efficient energy switch for growth and stress responses.
Virus-Induced Gene Editing and Its Applications in Plants
Authors: Zhang Chao , Liu Shanhe , Li Xuan , Zhang Ruixuan , Li Jun
Published: September 2022

CRISPR/Cas-based genome editing technologies, which allow the precise manipulation of plant genomes, have revolutionized plant science and enabled the creation of germplasms with beneficial traits. In order to apply these technologies, CRISPR/Cas reagents must be delivered into plant cells; however, this is limited by tissue culture challenges. Recently, viral vectors have been used to deliver CRISPR/Cas reagents into plant cells. Virus-induced genome editing (VIGE) has emerged as a powerful method with several advantages, including high editing efficiency and a simplified process for generating gene-edited DNA-free plants. Here, we briefly describe CRISPR/Cas-based genome editing. We then focus on VIGE systems and the types of viruses used currently for CRISPR/Cas9 cassette delivery and genome editing. We also highlight recent applications of and advances in VIGE in plants. Finally, we discuss the challenges and potential for VIGE in plants.
Biochemical and Neuropathological Findings in a Creutzfeldt–Jakob Disease Patient with the Rare Val180Ile-129Val Haplotype in the Prion Protein Gene
Authors: Zanusso Gianluigi , Colaizzo Elisa , Poleggi Anna , Masullo Carlo , Romeo Raffaello , Ferrari Sergio , Bongianni Matilde , Fiorini Michele , Tiple Dorina , Vaianella Luana , Sbriccoli Marco , Porreca Flavia , Equestre Michele , Pocchiari Maurizio , Cardone Franco , Ladogana Anna
Published: September 2022

Genetic Creutzfeldt–Jakob disease (gCJD) associated with the V180I mutation in the prion protein (PrP) gene (PRNP) in phase with residue 129M is the most frequent cause of gCJD in East Asia, whereas it is quite uncommon in Caucasians. We report on a gCJD patient with the rare V180I-129V haplotype, showing an unusually long duration of the disease and a characteristic pathological PrP (PrPSc) glycotype. Family members carrying the mutation were fully asymptomatic, as commonly observed with this mutation. Neuropathological examination showed a lesion pattern corresponding to that commonly reported in Japanese V180I cases with vacuolization and gliosis of the cerebral cortexes, olfactory areas, hippocampus and amygdala. PrP was deposited with a punctate, synaptic-like pattern in the cerebral cortex, amygdala and olfactory tract. Western blot analyses of proteinase-K-resistant PrP showed the characteristic two-banding pattern of V180I gCJD, composed of mono- and un-glycosylated isoforms. In line with reports on other V180I cases in the literature, Real-Time Quaking Induced Conversion (RT-QuIC) analyses did not demonstrate the presence of seeding activity in the cerebrospinal fluid and olfactory mucosa, suggesting that this haplotype also may result in a reduced seeding efficiency of the pathological PrP. Further studies are required to understand the origin, penetrance, disease phenotype and transmissibility of 180I-129V haplotype in Caucasians.
Role of Cockayne Syndrome Group B Protein in Replication Stress: Implications for Cancer Therapy
Authors: Walker John R. , Zhu Xu-Dong
Published: September 2022

A variety of endogenous and exogenous insults are capable of impeding replication fork progression, leading to replication stress. Several SNF2 fork remodelers have been shown to play critical roles in resolving this replication stress, utilizing different pathways dependent upon the nature of the DNA lesion, location on the DNA, and the stage of the cell cycle, to complete DNA replication in a manner preserving genetic integrity. Under certain conditions, however, the attempted repair may lead to additional genetic instability. Cockayne syndrome group B (CSB) protein, a SNF2 chromatin remodeler best known for its role in transcription-coupled nucleotide excision repair, has recently been shown to catalyze fork reversal, a pathway that can provide stability of stalled forks and allow resumption of DNA synthesis without chromosome breakage. Prolonged stalling of replication forks may collapse to give rise to DNA double-strand breaks, which are preferentially repaired by homology-directed recombination. CSB plays a role in repairing collapsed forks by promoting break-induced replication in S phase and early mitosis. In this review, we discuss roles of CSB in regulating the sources of replication stress, replication stress response, as well as the implications of CSB for cancer therapy.
Pirenzepine Binding Sites in the Brain of the Honeybee Apis mellifera: Localization and Involvement in Non-Associative Learning
Authors: Messikh Chaïma , Gauthier Monique , Armengaud Catherine
Published: September 2022

Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopolamine, on olfactory associative memory. Binding sites for the mAChR antagonist BODIPY® FL pirenzepine were localized in the brain of the honeybee forager. Pirenzepine binding sites were detected indifferently in several somata and neuropilar areas. The highest binding site densities were present in the central complex and in somata of the dorsomedial border of the antennal lobes. An additional binding pattern was found in somata of the subesophageal ganglion. By contrast, Kenyon cell (KC) somata were not stained. Pirenzepine (PZ) effects on non-associative learning were evaluated. Treated animals required more trials for the habituation of the proboscis extension reflex (PER) than controls, and the duration of the PER increased after PZ brain injection. These results suggest that the network mediating habituation of the PER involves PZ binding sites that are not necessarily present on the circuitry mediating olfactory conditioning of the PER.
Polystyrene Microplastics Modulate the Toxicity of the Hydrophilic Insecticide Thiacloprid for Chironomid Larvae and Also Influence Their Burrowing Behavior
Authors: Krais Stefanie , Anthes Nils , Huppertsberg Sven , Knepper Thomas P. , Peschke Katharina , Ruhl Aki S. , Schmieg Hannah , Schwarz Tabea , Köhler Heinz-R. , Triebskorn Rita
Published: September 2022

As there is still little knowledge of interactions between microplastics (MP) and hydrophilic compounds, we propose ways the toxicity of hydrophilic pesticides can be modulated by MP, when sorption can be excluded. Larvae of Chironomus riparius were exposed to thiacloprid (TH, 1 µg/L) and polystyrene microplastic particles (PS; <50 µm; 150,000 and 1,000,000 particles/L) for 96 h, solely or in co-exposure. Burrowing behavior and mortality were observed. Larvae in treatments containing PS established themselves quicker in the sediment and kept the ability to rebury for a longer time compared to control and TH, respectively. While TH elevated the mortality, exposure to PS alone did not affect the survival of the larvae. In co-exposure of TH and PS, a concentration of 150,000 particles/L significantly reduced the toxicity of 1 µg/L TH after 96 h, an effect that was not observed at 1,000,000 particles/L. Therefore, we hypothesize that this modulation of the toxicity of TH eventually may have resulted from a combination of a ‘protective MP layer’ in the gut and a higher retention time of particles in larvae exposed to 150,000 particles/L than in those exposed to 1,000,000 particles/L due to the lower number of ingestible particles in the former.
Case study: Empirical study on indoor environmental sound classification to support hearing-impaired persons
Authors: Nakaya M. , Asakura T.
Published: September 2022

Hearing-impaired persons often find it extremely difficult to catch and identify environmental sounds, which often include a wide variety of information types that would help them to function more effectively in their surrounding environments. Because of this, it would be very helpful
if such persons could be supported by providing them with various kinds of event information in the form of visual data. The ultimate purpose of this research is to classify various types of environmental sounds that can provide important clues from the viewpoint of safe-living and then apply
machine learning techniques to visually display that information in real time on smartglasses. Specifically, our method extracts the acoustic features of environmental sounds from their time-, frequency-, and time-frequency-domain characteristics and then classifies those sounds based on their
extracted features. Ultimately, such information will be visually displayed on smartglasses, thus allowing hearing-impaired persons to process those environmental sounds while continuing to observe the world around them in a normal manner. In this paper, the validity of our empirical and academic
research into machine learning-based environmental sound classifications is discussed.
Proceso de timbrado y organización de paletizado en el área de cámara EDPACIF S.A.
Authors: Minga Delgado Ricardo Isaías , Pastrán Calles Félix Reinaldo
Published: September 2022

El objetivo de esta investigación consistió en aplicar una nueva gestión del proceso de timbrado y organización de paletizado en el área de cámara de la empresa EDPACIF S.A. con el propósito de generar mayor calidad de trabajo e identifica los procesos, y mejorar los procedimientos industriales La metodología fue descriptiva, explicativa y cuantitativa en donde se aplicaron técnicas de recolección de datos a todos los trabajadores del área de cámara de la empresa EDPACIF S.A. la observación de campo permitió conocer las diferentes problemáticas que presenta en el área de la empresa, donde se conoció la gravedad de los procesos y la situación que se presenta dentro de la misma, evidenciando la afectación en el rendimiento de los procesos industriales de producción, por lo que se presenta un nuevo proceso de mejorar.
UPAYA MENINGKATKAN HASIL BELAJAR SISWA DALAM MATA PELAJARAN MATEMATIKA MELALUI MODEL PEMBELAJARAN MIND MAPPING PADA SISWA KELAS XI IPA.3 SMA N 1 KINALI
Authors:   SMA N 1 KINALI, Budiman Hendri
Published: September 2022

Based on the results of student learning IPA.3 Class XI SMAN 1 Kinali in Mathematics was found that results for students in the subjects of Mathematics is still very low. The average student learning outcomes are still under KKM. The purpose of this study is to describe and obtain information about the efforts to improve student learning outcomes in mathematics sub Using many parts division algorithm to determine the quotient and remainder of the division through Mind Mapping learning model in Class XI SMAN 1 Kinali IPA.3 West Pasaman , This research is a class act. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subject of the study consisted of 40 students Class XI IPA.3SMA N 1 Kinali. Data were collected by using observation sheet and daily tests. Data were analyzed using percentages. Based on the results of research and discussion that has been raised, it can be concluded that Mind Mapping learning model can improve student learning outcomes in mathematics sub Using sukubanyak division algorithm for determining the quotient and remainder pembagiandi SMA N 1 Kinali. Learning outcomes of students from the first cycle to the second cycle. The results of students in the first cycle was 52.48 (Enough) increased to 83.83 (Good) with an increase of 31.35%.
UPAYA MENINGKATKAN HASIL BELAJAR SISWA DALAM MATA PELAJARAN MATEMATIKA MELALUI METODE SNOWBALL THOROWING PADA SISWA KELAS XII.IPA2 SMA NEGERI 1 KINALI
Authors:   SMA NEGERI 1 KINALI, Nuridha Nuridha
Published: September 2022

Based on the results of student learning XII.IPA2 Class SMA N 1 Kinali in Mathematics was found that results for students in the subjects of Mathematics is still very low. The average student learning outcomes are still under KKM. The purpose of this study is to describe and obtain information about the efforts to improve student learning outcomes in mathematics sub Specifies the nth row and the sum of n term of arithmetic and geometry through Thorowing Snowball Method in class XII.IPA2 SMA N 1 Kinali West Pasaman . This research is a class act. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subject of the study consisted of 36 students Grades XII.IPA2 SMA N 1 Kinali. Data were collected by using observation sheet and daily tests. Data were analyzed using percentages. Based on the results of research and discussion that has been raised, it can be concluded that the Snowball Method Thorowing can improve student learning outcomes in mathematics sub Specifies the nth row and the sum of n term of arithmetic and geometry in high school N 1 Kinali. Learning outcomes of students from the first cycle to the second cycle. The results of students in the first cycle was 46.69 (Not Good) increased to 83.86 (Good) with an increase of 37.17%.
СИСТЕМА ПРОФЕСІЙНОЇ ОСВІТИ ДОРОСЛИХ В УКРАЇНІ ТА ЦЕНТРАЛЬНІЙ ЄВРОПІ
Authors: Boichuk Yu. D. , Boiarska-Khomenko A. V. , Shtefan L. A.
Published: September 2022

У статті визначено, що професійна освіта дорослих в Україні потребує суттєвого реформування з урахуванням прогресивних змін у європейському освітньому просторі. Було виявлено спільні та відмінні підходи до впровадження професійної освіти дорослих. Спільними аспектами є такі: інтеграція в європейський освітній простір; врахування міжнародних тенденцій розвитку професійно-технічної освіти дорослих; прагнення до вдосконалення системи професійно-технічної освіти дорослих на основі гармонізації національних традицій зі світовими вимогами та стандартами; орієнтація на розвиток професійної освіти дорослих у контексті навчання впродовж життя; усвідомлення необхідності реформування системи професійно-технічної освіти дорослих відповідно до вимог суспільства, економіки та сучасного ринку праці тощо.

Відмінними аспектами системи професійно-технічної освіти дорослих в Україні є: недосконалість нормативно-правової бази щодо визначення мети, завдань, функцій професійно-технічної освіти дорослих, регулювання діяльності суб’єктів освітнього процесу, визначення їх прав та обов’язків, характер взаємодії з державою; недостатньо високий рівень економічного забезпечення розвитку професійно-технічної освіти дорослих, недосконалість принципів і форм фінансування; невизначеність функцій центральних та місцевих органів виконавчої влади з організації професійно-технічної освіти дорослих; відсутність нормативного врегулювання питань системного визнання та атестації професійних кваліфікацій та компетенцій, здобутих у неформальній та інформальній освіті; недосконалість системи акредитації та оцінки попереднього професійного досвіду; відсутність достатнього потенціалу державних організацій для розвитку, координації, управління системою освіти дорослих; недостатньо високий освітньо-кваліфікаційний рівень, компетентність і конкурентоспроможність управлінських, педагогічних, наукових кадрів у сфері професійної освіти дорослих та інші.
АКТУАЛЬНІ ПИТАННЯ ОРГАНІЗАЦІЇ НАУКОВО-ПЕДАГОГІЧНОЇ ПРАКТИКИ У ПРОЦЕСІ ПІДГОТОВКИ ЗДОБУВАЧІВ ДРУГОГО (МАГІСТЕРСЬКОГО) РІВНЯ ВИЩОЇ ОСВІТИ ЗА СПЕЦІАЛЬНІСТЮ 011 ОСВІТНІ, ПЕДАГОГІЧНІ НАУКИ
Authors: Друганова О. М. , Зеленська Л. Д. , Білик В. М.
Published: September 2022

У статті представлено актуальні питання реалізації практичного складника підготовки здобувачів магістерського рівня вищої освіти в галузі 01 Освіта/Педагогіка, зокрема, за спеціальністю 011 Освітні, педагогічні науки. Метою статті є розкриття змісту, напрямів, форм організації науково-педагогічної практики за освітньою програмою «Освітологія» в Харківському національному педагогічному університеті імені Г.С. Сковороди.

З’ясовано, що науково-педагогічна практика, як важливий компонент цілісної системи підготовки викладача вищої школи, вимагає створення необхідного інструментарію для здійснення його особистісного і професійного розвитку.

Доведено, що у процесі проходження науково-педагогічної практики відповідно до освітньої програми «Освітологія» Харківського національного педагогічного університету імені Г.С. Сковороди у здобувачів магістерського рівня спеціальності 011 мають бути сформовані такі компетентності, як: здатність застосовувати знання у практичних ситуаціях; здатність до адаптації та дії в новій ситуації з урахуванням соціального, гендерного та вікового розмаїття учасників освітнього процесу; здатність критично осмислювати проблеми у сфері освіти; здатність гармонізувати групову взаємодію учасників освітнього процесу; здатність проводити педагогічне дослідження, добирати відповідні методи, сучасні методики та інструменти обробки й інтерпретації даних; здатність розробляти і реалізовувати нові освітні інструменти, проєкти та інтегрувати їх в освітнє середовище закладу освіти, створювати індивідуалізоване навчальне і/або підтримуюче середовище, використовувати сучасні інформаційно-комунікаційні та цифрові технології в освітній та дослідницькій діяльності тощо.

У статті зазначено, що досягненню програмних результатів за освітньою програмою «Освітологія» відповідно до робочої навчальної програми «Науково-педагогічна практика» сприяють два модулі: «Організація науково-педагогічної практики здобувача вищої освіти» та «Науково-педагогічна діяльність здобувача вищої освіти» (охоплює такі змістові модулі: навчально-методична, виховна, науково-дослідна діяльність). Кожний з них передбачає свої завдання. Автори наголошують, що з метою формування професійного образу, власного іміджу, набуття педагогічної майстерності, реалізації життєвих і кар’єрних цілей здобувача програмою практики передбачено: відвідування навчальних занять керівників практики та професорів кафедри, самостійне проведення магістром-практикантом лекції, семінарського заняття з одного із освітніх компонент педагогічного циклу за предметною спеціалізацією.
GRAMMAR OF THE IDIOSTYLE IN POETRY (on the example of Georgy Ivanov`s poems)
Authors: ILIESKU Viktoriia
Published: September 2022

The article deals with the study of the grammar of idiostyle in poetry. Theoretical basis of the study of grammar of poetic idiostyle based on the material of poetry is the doctrine of the inner form of a word and language features, the theory of morphological field and achievements of functional grammar, modern developments in the field of linguistics, linguopoetics, and poetic aesthetics. In the structure of the poetic text, a unit of any of the levels is capable of possessing expressiveness, being an expressive unit, interacting with other levels. The semantic and functional enrichment of grammatical means in the poetic language of the 19th-20th centuries has an individual-author character, based on the systemic grammatical potential of the national language. As a consequence, these enriched units and categories form the grammatical system of poetic language as a subset of the national language. “Poetic cognition” is verbal in nature. The tools of “poetic cognition” are the artistic word and the structure of language as a system of connections and relations between linguistic units. Linguopoetic mechanisms of grammatical meanings actualization and neutralization in poetic language are based on general linguistic characteristics of morphological categories and on the regularities of poetic functioning, the selection of neutral and marked grammemes. In addition to the violation of the grammatical norm, poetic language has a variety of artistic techniques and forms patterns, the basis of which is morphological selection and the formation of homogeneous groups, series, texts and their fragments, morphological attraction (assimilation of some morphological units to others). Besides, verse localization is a means of isolating and neutralizing the semantics of a certain unit. Within the framework of general poetic patterns in each text and “idiostyle” an authorial system of morphological selection and attraction is formed, which forms units and unities. The dynamics of the development of techniques and poetic means can be considered both within the framework of an individual work and in the comparative dimension, at the level of describing the idiostyle of an individual artist and in the idiostyles of different authors. Grammatical selection creates a variety of morphological dominants in individual works.
THE IMAGE OF THE TREE AS THE EMBODIMENT OF COSMOLOGICAL AND SOLAR ASPECTS IN J. R. R. TOLKIEN’S WORKS
Authors: KOZII Olha
Published: September 2022

English scientist J. Tolkien became world-famous as the creator of the fantasy genre and the author of the epic novel «The Lord of the Rings» which has overgrown the measures of a novel having become a cultural phenomena and causing cultural movement. His works – «The Lord of the Rings» and «The Hobbit» have already been analyzed in the light of the genre novelty. The purpose of this paper is to enlighten the ways of the embodiment of philosophical concepts of the image of the world tree in J. Tolkien’s creative work. The methodology includes literature review related to the topic; methods of analysis, classification and comparative analysis. The image of the tree is analyzed as one of the universal symbols of the spiritual culture. It unites the Earth with the heaven, defines the human’s way to oneself, to spiritual summits. In the works of J. R. R. Tolkien the tree isn’t just a detail but also a character, the symbol of the eternal life circulation. Symbolizing the synthesis of heaven, earth and water, the dynamics of life, combining the worlds, the tree in the creation of J. Tolkien is a complex archetypal derivative that accumulates feminine as a source of life, male as a defender of the genus. The Trees of Valinor, lone tree-pastors, the creations of Niggl are characterized by the synthesis of cosmogonic and solar aspects. The depth of the perception of the artist («The Leaf by Niggle») the writer transforms into world creation. Niggle works much on details, but dreams of drawing the whole tree. The artist is inspired by a picture of a living tree, the embodiment of the mythological universe. It is concluded that the close relationship between the creator and creation is a reflection of the ancient beliefs about man and the tree as indivisible unity, that the tree could become a friend, a «twin brother» of a man, the incarnation of his soul.
Quality Control and Entrepreneurship Sustainability
Authors: Justina Oboreh
Published: September 2022

This paper examined the effect of quality control on organizational product and the needs for sustainability Innoson Motors in Anambra State, Nigeria. The paper formulated two research questions and two hypotheses which were tested at 0.05 level of significance using Spearman’s Rank Order Correlation Coefficient. Cross-sectional survey was used in collecting data for the study. The paper revealed that there is strong link between quality control and sales, and there is a perfect linear relationship between sales volume and product quality. The paper recommends that management should organize seminars, workshops on quality control for their staff to enhance sales and sustainability.
Institutional Logic, Dilemma and Suggestions of Open Source Innovation: A Case Study of Blockchain
Authors: Xiaohong Chen
Published: September 2022

Open-source software has made a breakthrough in the traditional intellectual property theory from the aspects of Copyright, patent right, and trademark right, and it has created a new property rights form in the form of license. Taking blockchain as an example, this paper analyzes bitcoin and Ethereum and their open-source licensing strategies. At the same time, it explores the problems encountered in the property rights of open-source blockchain and three possible solutions to this dilemma: The industry-standard licensing plan, blockchain open-source licensing scheme, and open patent scheme. This research will be significant for expanding and enriching the theoretical and practical analysis of blockchain open source in the field of intellectual property.
Reseña: “Desafios educacionais e tecnologias na aprendizagem ativa”
Authors: Alves Antonia Nilda
Published: September 2022

Reseña del libro "Desafios educacionais e tecnologias na aprendizagem ativa". Este libro trae contribuciones de investigadores e investigadoras de Brasil, Argentina y Ecuador.
Zulema Solana, figura ejemplar de docente e investigadora
Authors: Narvaja de Arnoux Elvira
Published: September 2022

Elvira Narvaja de Arnoux escribe un homenaje a la ejemplar docente e investigadora Zulema Solana, a quien va dedicado este número de la Revista Infosur.
Protection of critical infrastructure in Norway – factors, actors and systems
Authors: Godzimirski Jakub
Published: September 2022

The main aim of this article is to examine how the issue of protecting critical infrastructure is addressed in Norway. To answer this question, the article addresses two important sub-questions – what is to be understood in the current historical and the specific Norwegian context as important elements of national critical infrastructure and what is the current understanding of risks and threats that this infrastructure should be protected against? This article is based on a detailed quantitative and qualitative examination of the official Norwegian documents and statements on questions related to various aspects of protecting critical infrastructure in Norway. In section one, structural factors that have played a major part in shaping Norwegian thinking about critical infrastructure are discussed. Section two provides a short summary of the current discussion on elements of critical infrastructure in Norway. In section three, the article discusses official Norwegian perceptions of threats and how they address questions related to critical infrastructure. The fourth section looks at the current official approach to protection of critical infrastructure in the country. The process of building the existing system for protecting critical infrastructure in Norway has been driven by both domestic and international concerns. The system should make it possible for citizens to meet their needs through access to various important societal functions, but it also needs to make it possible to address challenges that stem from the international environment.
Contribución al estudio de la volumetría físico-química
Authors:   , Lanza Dominga C.
Published: September 2022

Contiene la descripción del método de volumetría físico-química aplicable a la conductibilidad eléctrica. Este método incluye disociación electrolítica, medida de la conductibilidad, dosajes: neutralización, precipitación y desplazamiento.
Analysis of Competitiveness Factors of Global Innovative Companies
Authors:   Korea Trade Research Association, Kim Jae-Kyung , Yoon Jon-Mo , Lee Bong-Soo
Published: September 2022

Purpose - This study’s purpose is to analyze which factors are more important to strengthening the competitiveness of global innovative companies by firstly sampling global 40 enterprises, secondly investigating of study models empirically, thirdly finding out significant implications through research, and finally using this result to help improve global companies’ competitive edges.
Design/methodology - Developing three research models of hypothesis and using 5 variables such as technology innovation, knowledge management, human resource development, sustainable management, and corporate life, this study was empirically carried out by reliability and validity testing, correlation analysis of variables, and multiple regression analysis of three research models.
Findings - Through proceeding empirical analysis study, we found out that technology innovation and sustainable management had a significant impact on strengthening competitiveness through the hypothesis test. Those two factors had positive results and a synergy effect through correlation analysis along with process change and human resource development, which are also important areas in global innovative companies.
Originality/value - In line with the fourth industrial revolution era’s acceleration and COVID-19’s large impact on all industries, global companies are newly developing their business models to cope with external environment change. This study’s results would be meaningful for global enterprises and domestic companies to improve their overall competitive edge by reinforcing their innovation strategy, preparing next growth engines, diversifying business portfolios, and setting business milestones.
Evaluación de Organizaciones de Gestión de Destino (OGD): El caso del destino Lago Titicaca - Perú
Authors: Flores Antonio , Cayo-Velásquez Noemi
Published: September 2022

Esta investigación tuvo como propósito evaluar al ente gestor (OGD) del destino Lago Titicaca, provincia de Puno – Perú, midiendo la eficacia de sus instrumentos de planificación turística y buscando establecer una relación entre dicha eficacia y su capacidad de gestión de destinos. Para tal fin se optó por una metodología de enfoque mixto, con un diseño no experimental, descriptivo y correlacional de corte transversal. A partir de un muestreo no probabilístico de tipo intencional, se aplicó una encuesta estructurada con una escala de Likert a los gestores públicos y stakeholders intervinientes en el espacio turístico mencionado. Los resultados permitieron evidenciar que los instrumentos de planificación turística no son eficaces, con grandes desfases e inconsistencias entre los mismos. Además, existe una relación directa entre la eficacia dichos instrumentos y la capacidad de gestión del ente competente del destino, limitando las oportunidades de desarrollo y competitividad de su propio destino. Es posible afirmar que para un fortalecimiento de gestión se requiere de un ente líder, representativo y coherente con sus acciones y medidas planificadas.
Differences in Catches based on The Use of different Colour of Collector Lamp on the Boat Lift-Net in Polewali Mandar District, West Sulawesi
Authors: Azakhrah Nur Waza , Kurnia Muhammad , . Fahrul , . Musbir , Hajar M. Abduh Ibnu
Published: September 2022

Boat lift net  is an active fishing gear that operates at night using a lamp whose light functions to attract pelagic fish. The purpose of this study is to determine the difference between the catches of the two boat lift net using collecting lights of different colors, this research was held in Polewali Mandar waters in September-November 2020 by following the operation of catching 2 boat lift units. The results showed that the boat using the green collecting light caught 1876.6 kg more fish than the boat using the red light 1534.4 kg, and boat that use green lights have more variety of fish species than boat that use red lights. The different types of fish in the two units of boat lift net are grouper, kerung-kerung, and shark.
Operational Performance of Fish Landing Base (PPI) Lappa Sinjai Regency
Authors: Rahmadani Zalzah , Kurnia Muhammad , Mallawa Achmar
Published: September 2022

This study aims to analyze the level of operational perfomance the fishing port clas PPI Lappa of Sinjai Regency. The research method used in a case study with the aspects studied include the provision of facilities used in PPI Lappa operational activities. Data were analyzed descriptively using the scoring method and operational performance appraisal table. The performance assessment is obtained by comparing the current condition of PPI Lappa with the provisions in the regulations stipulated of The Ministry of Maratime Affairs and Fisheries No. PER.08/MEN/2012 concerning fishing ports and the decision of the Director General of Capture Fisheries No.432/DPT3/0T.220.D3/I/2008 regarding guidelines for evaluating the performance of fishing port technical implementing units. The results of the study show that the performance of coconut PPI Lappa is 63,6 % or good performance status. Each parameter has a high percentage of weight and value success, includes the number of produnction 960,05%, ship visting frequensy 73,3%, ice service 458,10 %, fuel service ships 175,40%, clean water service  22,05%  and the availability  of port fasilities such as administration office, national marketing, marketing facilities, canteen, and mosque. The facilities available but not functioning are the guard post. Facilities that are not available, such as industrial facilities, processing facilities, ship repair facilities, supply facilities for engine parts and polyclinics.
Effect of Bacillus Sp. Bacteria on The Growth of Saline Tilapia (Oreochromis niloticus) in The Biofloc System
Authors: Ikbal Muhamad , Soadiq Syawaluddin , . Murni , Anwar Asni , . Akmaluddin , Malik Abdul , . Burhanuddin
Published: September 2022

One alternative to increase production is to maximize the use of biofloc system cultivation technology. However, the problems in biofloc cultivation are; the difficulty of cultivators to replace or alternatively use commercial bacteria to increase production. One of the efforts made is the use of bacillus sp. The aim of the study was to determine the optimal concentration of bacillus sp that could increase the growth of saline tilapia. This study used a completely randomized design (CRD) with four treatments, each repeated three times, so that there were 12 units. This study tested the concentration of Bacillus sp. 0.0028 ml/L, 0.0030 ml/L, 0.0032 ml/L, and 0.0034 ml/L. The results showed that the highest protein retention was 9.91%, fat retention was 2.05% and the body glycogen content of saline tilapia was 0.68%. This shows that the administration of Bacillus sp. in saline tilapia culture media has a real effect.
Feasibility Analysis of Vanname Shrimp Ponds in Various Cultivation Technology Systems (Case Study in Manakku Village, Labakkang District, Pangkep Regency)
Authors: Amri Muhammad Irwandhi , Haris Abdul , . Jumiati
Published: September 2022

Vanname shrimp is a fishery commodity that is currently popular with many people because vanname shrimp is more free and resistant to disease and is a promising business prospect for cultivators. Shrimp cultivation business in educational ponds at the University of Muhammadiyah Makassar located in Manakku Village, Labakkang District, Pangkep Regency is a business with vanname shrimp commodities. This study aims to determine the amount of costs and income, business studies on various vanname shrimp culture technologies carried out by 3 vanname shrimp farmers. This is done to assess whether the cultivation business is feasible or not feasible to be developed. Based on the business studies carried out, it can be seen that the vanname shrimp cultivation business in the education pond is profitable. The research results obtained are; 1) The investment cost for each farmer is Rp. 19,000,000,-. The total cost of vanname shrimp farming per farmer is Rp. 71.818.750, -, Rp. 140,685,000, -, and Rp. 207,712,500,-. The total cost of vanname shrimp farming is the sum of fixed costs and variable costs. The total income of vanname shrimp farming business earned by each farmer is Rp. 44,871,250,-, Rp. 75,960,000, -, and Rp. 67.287.5000,-. 2) The study of shrimp farming resulted in R/C ratio per farmer of 1.62, 1.54 and 1.32, the value of B/C Ratio of 0.62, 0.54 and 0.32, Break Event Point (BEP ) divided into 2, namely BEP Volume and BEP price. The value of BEP Production/volume per farmer is 1025.98 kg, 2164.38 kg, and 41542.50 kg, while the price BEP is Rp. 43,083, Rp. 42,210 and Rp. 41,543.
Growth Performance of Tilapia Oreochromis niloticus with the Provision of GDM Probiotics maintained with the Biofloc System
Authors: Hadijah Hadijah , Gatta Ratnawati , . Rusmin
Published: September 2022

Tilapia is one type of freshwater fish that has economic value. This type of fish has good adaptability and fast growth. One of the problems in tilapia cultivation is that probiotics have not been utilized in the maintenance media with a biofloc system. This study aimed to determine the dose of probiotic supplementation in the formation of bioflocs on the growth and survival of tilapia. The research was conducted at the Educational Pond, Bosowa University, Maros Regency. The test animals used were tilapia seeds measuring 2-3 cm long. The stocking density of 3 seeds/L were kept in a basin with a capacity of 80 L filled with 60 L of water. The treatment tested was GDM probiotic supplementation in media with doses of A 5%, B 6%, C 7%, and D 0 %. The study used a completely randomized design with 4 treatments and 3 replications so that there were 12 experimental units. Seeds were reared for 60 days by feeding Hi-Pro-Vite FF-99 as much as 3% of body weight biomass per day. The results showed that GDM probiotic supplementation with different doses significantly affected the growth and survival of tilapia. Supplementation of GDM probiotics 5%, 6% and 7% in the media gave the same effect on the growth and survival of tilapia but significantly different from the treatment without probiotics. The highest growth and survival rate of tilapia was obtained at a dose of 5%, 4.27g and 65%, respectively, while the lowest was in the treatment without probiotics, namely 3.27g and 48.33%. Based on the results of the study, it is recommended that 5% GDM probiotic supplementation in tilapia rearing containers is recommended.
The Characteristics of Fishing Ground Using Purse Seine in Makassar Strait and Flores Sea
Authors: . Safruddin
Published: September 2022

In order to optimally utilize marine fishery resources, the Government of the Republic of Indonesia divides Indonesian waters into 11 Fisheries Management Areas (IFMA), one of which is IFMA 713 which includes the waters of Bone Gulf, Bali Sea, Flores Sea and Makassar Strait. This study aims to provide information on the utilization of pelagic fish resources with a focus on the characteristics of fishing areas using purse seine fishing gear in the Makassar Strait and Flores Sea. In this study, 62 fishing trips using purse seines were carried out, each has 31 trips fishing operation in the Makassar Strait and in the waters of Flores Sea, respectively. The main catch and number for each water area was skipjack tuna (Katsuwonus pelamis) as many as 2,367 fish (Makassar Strait). While in the Flores Sea area, it is dominated by little tuna (Euthynnus sp) with a total of 11,039 fish. The results of this study indicate that the correlation of sea surface temperature with chlorophyll-a in the waters of the Makassar Strait and Flores Sea has a negative relationship with an optimum sea surface temperature of 30.5 °C for skipjack tuna and 28.0 °C for little tuna which corresponds to the chlorophyll-a concentration of 0.3 mg m-3 (skipjack tuna) and 0.2 mg m-3 for little tuna. The vertical distribution of skipjack tuna was found at the optimum depth of around 50 m, while most little tuna was caught in deeper waters around 250 m.
The Impacts Of Port Characteristics And Port Logistics Integration On Port Performance In Ethiopian Dry Ports
Authors:   Department of Logistics and Supply Chain Management, College of Business & Economics,Dilla University, Ethiopia, Ali Endris , Ayelign Abate ,   Department of Logistics and Supply Chain Management, College of Business & Economics,Dilla University, Ethiopia
Published: September 2022

Abstract: Purpose: This paper identifies the impacts of port characteristics and port-logistics integration on port performance in the case of Ethiopian dry ports. Research Methodology: To complete the study, we used structural equation modeling to test the relationship between port characteristics and port-logistics integration with port performance. Moreover, Statistical Package for Social Science is also used to filter indicators. Apart from this, the study was conducted in three dry ports of Ethiopia having a sample of 279 employees. Results: The finding shows that port characteristics such as port infrastructure, port connectivity, and port privatization have significantly impacted port performance. Also, port-logistics integration has an impact on both port operational performance and port efficiency. Limitations: The main limitation is that the study focused only on three dry ports of Ethiopia which do not include other dry ports in the country. Contribution: Ethiopia suffered forced dependency on transit countries after a blooded war with Eritrea which resulted in customs delays at port. To reduce this, the study suggests that Ethiopia should coordinate in developing joint infrastructures, and formulating unfettered rules and regulations with its transit countries. Keywords: 1. Port characteristics 2. Port logistics integration 3. Port operational performance 4. Port efficiency
Sentiment Analysis of Tweets on Telangana State Government Flagship Schemes
Authors:   Department of Statistics, Osmania University, Hyderabad, (Telangana), India, Bhuvaneshwari K. , Rani Dr. S. A Jyothi ,   Department of Statistics, Osmania University, Hyderabad (Telangana), India, Haragopal Dr. V. V. ,   Professor, Department of Statistics Mathematics, BITS Pilani, Hyderabad Campus, (Telangana), India.
Published: September 2022

Over the last decade, the usage of social media has evolved to a greater extent. Today, social media platforms like Twitter, facebook, snapchat are vastly used to incept the opinions of public about a particular entity. Social media has become a great source of text data. Text analytics plays a crucial role on social media data to give answers to a wide variety of questions about public feedback on many issues or topics. The primary objective of this work is to analyse the public opinion or sentiment in social media on Telangana state government welfare schemes. The purpose of sentiment analysis is to find opinions from tweets and extract sentiments from them and find their polarity, i.e., positive, neutral or negative. Here we are using twitter as it has gained much popularity and media attention. The first step is to extract the tweets on particular schemes through Twitter API and Python language followed by cleaning and pre- processing steps of the raw tweets. Then tfidf vectorizer was invoked for feature extraction and creation of bag of words and finally sentiment polarity scores were obtained by using VADER (Valence Aware Dictionary and sentiment Reasoner), lexicon and rule-based sentiment analysis tool.