Remote measurement-based care (RMBC) interventions for mental health - systematic review and meta-analysis (Preprint)
Authors: Michnevich Twyla , Machleid Felix , Huang Leu , Schröder-Frerkes Louisa , Wiegmann Caspar , Wiegmann Caspar , Muffel Toni , Kaminski Jakob 
Published: June 2024

BACKGROUND

Poor management of mental health conditions leads to reduced adherence to treatment, prolonged illness, unnecessary rehospitalisation and significant financial burden to the health care system. Recognizing this, ecological momentary assessment (EMA) and remote measurement-based care (RMBC) interventions have emerged as promising strategies to address gaps in current care systems. They provide convenient means to continuously monitor patient-reported outcomes, thereby informing clinical decision-making and potentially improving outcomes such as psychopathology, relapse, and quality of life.

OBJECTIVE

This systematic review and meta-analysis aims to comprehensively appraise and analyse the existing evidence on the use of EMA and RMBC for people living with mental illness.

METHODS

The study was conducted according to PRISMA-P guidelines and pre-registered with PROSPERO. A comprehensive search was conducted in four online databases using MeSH terms related to mental disorders and digital technologies. Studies were included if they included adults with a formally diagnosed mental disorder and measured symptoms using ecological momentary assessment or remote measurement-based care. Studies were independently reviewed by subgroups of authors and data were extracted focusing on symptom-focused or disease-specific outcomes, relapse, recovery-focused outcomes, global functioning, quality of life and acceptability of the intervention. We performed a descriptive analysis of demographic variables and a meta-analysis of randomised controlled trials. Risk of bias was assessed using the Cochrane risk-of-bias tool for randomised trials version 2.

RESULTS

The systematic review included K = 89 studies, of which k=13 used remote measurement-based care (RMBC). Of these, k = 8 were randomised controlled trials that were meta-analyzed. RMBC interventions varied in effectiveness, generally showing small but significant effects on symptom-specific outcomes, with notable effects on mania symptoms and empowerment. Adherence to all tracking items was 75.5% (k = 31). More prompts per day, but not more items per prompt, was associated with lower adherence. Adverse effects were infrequently reported and included technical problems and psychological distress. Concerns about bias were raised, particularly regarding participants' awareness of the interventions and potential deviations from the intended protocols.

CONCLUSIONS

Although RMBC shows growing potential in improving and tailoring psychiatric care to individual needs, the evidence of its clinical effectiveness is still limited. However, we found potential effects on mania symptoms and on empowerment. Overall, there were only a few RCTs with formal psychiatric diagnoses to be included in our analyses, and these had moderate risks of bias. Future studies assessing RMBCs effectiveness and long-term efficacy with larger populations are needed.

CLINICALTRIAL

PROSPERO CRD42022356176

INTERNATIONAL REGISTERED REPORT

RR2-10.1371/journal.pone.0297929