A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort
Authors: Pedrini Steve , Gupta Veer B. , Hone Eugene , Doecke James , O’Bryant Sid , James Ian , Bush Ashley I. , Rowe Christopher C. , Villemagne Victor L. , Ames David , Masters Colin L. , Martins Ralph N. ,   AIBL Research Group, Savage Greg , Wilson Bill , Bourgeat Pierrick , Fripp Jurgen , Gibson Simon , Leroux Hugo , McBride Simon , Salvado Olivier , Fenech Michael , Francois Maxime , Barnes Mary , Baker Jenalle , Barnham Kevin , Bellingham Shayne , Bomke Julia , Pejoska Sveltana Bozin , Buckley Rachel , Cheng Lesley , Collins Steven , Cooke Ian , Cyarto Elizabeth , Darby David , Dore Vincent , El-Sheikh Denise , Faux Noel , Fowler Christopher , Harrington Karra , Hill Andy , Horne Malcolm , Jones Gareth , Kamer Adrian , Killeen Neil , Korrel Hannah , Lamb Fiona , Lautenschlager Nicola , Lennon Kate , Li Qiao-Xin , Lim Yen Ying , Louey Andrea , Macaulay Lance , Mackintosh Lucy , Maruff Paul , Mcilroy Alissandra , Nigro Julie , Perez Kayla , Pertile Kelly , Restrepo Carolina , Cardoso Barbara Rita , Rembach Alan , Roberts Blaine , Robertson Jo , Rumble Rebecca , Ryan Tim , Sach Jack , Silbert Brendan , Thai Christine , Trounson Brett , Volitakis Irene , Vovos Michael , Ward Larry , Watt Andrew , Williams Rob , Woodward Michael , Yates Paul , Ugarte Fernanda Yevenes , Zhang Ping , Bird Sabine , Brown Belinda , Burnham Samantha , Chatterjee Pratishtha , Cox Kay , Fernandez Shane , Fernando Binosha , Gardener Sam , Laws Simon , Lim Florence , Lim Lucy , Tegg Michelle , Lucas Kathy , Martins Georgia , Porter Tenielle , Rainey-Smith Stephanie , Rodrigues Mark , Shen KaiKai , Sohrabi Harmid , Taddei Kevin , Taddei Tania , Tan Sherilyn , Verdile Giuseppe , Weinborn Mike , Farrow Maree , Frost Shaun , Hanson David , Hor Maryam , Kanagasingam Yogi , Leifert Wayne , Lockett Linda , Riley Malcolm , Saunders Ian , Thomas Philip 
Published: October 2017

Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer’s participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ε4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.