bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender Perceptions towards Diversity Management Practices in the Public Sector
Authors: Ali Inayah , Narayan Jashwini , Appana Subhash
Published: August 2023

This study aims to examine the differences in the perception of male and female employees towards diversity management and their work outcomes in a highly male-dominated culture in the Public Sector. A quantitative survey of 114 public sector employees was analysed using structural equation modelling. Overall, the findings reveal that diversity management has a positive and significant impact on both genders’ work outcomes of affective commitment, organisational commitment, job satisfaction, work group performance and inclusiveness of organisational culture. However, the male employees reported lower levels of organisational commitment than the female employees. This study highlights key suggestions for policymakers and public managers, such as diversity strategy, top leadership commitment, diversity training programs, team bonding exercises, strengthening of family-friendly programs and other suggestions. The theoretical contribution of this research is the integration of representative bureaucracy theory, commitment management theory and social cognitive theory for a robust argument for diversity management in the public sector. Studies on gender perceptions in developing small island countries are rare. This study is the first of its kind in the subject country. It identifies the distinct gender norms in society and the role of diversity management.
Pemanfaatan Social Media Marketing Tools Sebagai Sarana Pemasaran Produk UMKM
Authors: Fitrani Laqma Dica , Herlambang C.P Yudha , Hasanah U.D Nurul , Purnamasari Linda , Hudiwinarsih Gunasti , Riqqoh Abdullah Khoir
Published: August 2023

This community service activity aims to increase the skills and knowledge of FnF MSMEs regarding the application of Social Media Marketing Tools as a means of online business marketing. The community service team provides training on social media marketing by utilizing the WA Business and Instagram Business applications. The stages of implementing community service include preparation, implementation, practice, and evaluation. This activity was carried out at Perbanas Hayam Wuruk University and was attended by FnF UMKM owners. The implementation activity contained two training sessions, the first was training related to WA Business, and the second was Instagram Business. The results of this community service showed a 100% increase based on the knowledge identified from the pretest and posttest evaluation results. Besides that, FnF UMKM had skills in managing WA Business and Instagram Business as online social media to support the marketing of their superior products.
Pelatihan Kompetensi Kewirausahaan dan Digital Marketing guna Mengoptimalkan Penjualan Produk UMKM di Desa Wisata Jipangan
Authors: Nugroho Ginanjar Setyo , Muchran Murniady
Published: August 2023

This service aims to improve the competencies in order to optimize sales of MSME products. The method of this service is participatory training. The partner of this service is several MSME owners in Jipangan Tourism Village, Bangunjiwo, Kasihan, Bantul, Special Region of Yogyakarta. The activity evaluation instrument uses a pre-test and post-test, which is then analyzed descriptively. The results of this service show that there is an increase in MSME owners’ knowledge related to entrepreneurship by 70% and knowledge related to digital marketing by 37,5%. In addition, MSMEs have the motivation to keep trying to develop their products with innovative patterns in creating more significant opportunities by maximizing marketing through the use of social media.
Pelatihan Penanaman Toga Sebagai Upaya Trauma Healing bagi Siswa SD Terdampak Gempa Bumi Cianjur
Authors: Kismiati Dyah Aniza , Hutasoit Leonard R. , Wahyuningsih Tri , Ratnaningsih Anna , Sekarwinahyu Mestika
Published: August 2023

This community service activity aims to eliminate the trauma of children affected by the earthquake through family medicinal plant planting (TOGA) activities at SD Negeri Sukamaju 1 Cianjur Regency. This method of implementing service uses training consisting of 3 stages of activities, namely, the preparation stage, the implementation stage and the evaluation stage. This activity is held in 2 ways, namely through the delivery of TOGA material in the classroom and TOGA planting practice activities in the schoolyard. The activity was also interspersed with ice breaking, namely by doing happy gymnastics guided by the facilitator lecturers. This activity evaluation instrument uses pre-test and post-test and is then analyzed descriptively. The results of this service show that there is an increase in students' insight into TOGA, which can be seen from the increase in post-test results by 10%. In addition, students have the skills to plant and care for family medicinal plants (TOGA).
Implementation of the Reasoning Training Program for Optimizing the UTBK Test at SMAN 1 Parepare
Authors: Rahmi Nur , Ekasasmita Wahyuni , Adhalia H. Nurul Fuady , Fajri Ahmad , Miftahulkhairah Miftahulkhairah , Sarmila Sarmila , Yusuf Muh.
Published: August 2023

This community service  aims to analyze and evaluate the implementation of a reasoning training program for optimizing the UTBK at SMAN 1 Parepare. The service involved 40 students from the twelfth grade who served as participants in the training program. The community service method used was quasi-experimental with a single-group pretest-posttest control design. The data analysis showed that the reasoning training program was effective in improving the UTBK results. There was a significant improvement in the average scores of the group that underwent the training compared to the control group. Additionally, the training program also assisted students in developing analytical and critical skills, which had a positive impact on their overall academic performance. This community service concludes that the implementation of the reasoning training program plays a crucial role in optimizing the UTBK at SMAN 1 Parepare. The results of this service contribute significantly to efforts to enhance student preparation for facing the UTBK and support their success in achieving better results in college admissions.
CHARLES SANDERS PEIRCE’ÜN DİN FELSEFESİ
Authors: KARGIN Hasan Hüseyin
Published: August 2023

Charles Sanders Peirce, Tanrı’nın varlığı yerine Tanrı’nın gerçekliği savını öne sürer. Düşünür, gerçekliğin var olmayı (mevcudiyeti) kapsayan daha geniş bir kavram olduğunu belirtir. Tanrı insanın yanındadır ve din insan deneyiminden türeyen bir inanış bütünlüğüdür. Dinin kurumsallaşması (kilise teşkilatı gibi) canlı, dinamik dine zarar vermekte, bilim ile dinin bütünlüğüne ve tamamlayıcılığına sekte vurmaktadır. Aslında bilim ile din bir elmanın iki yarısı gibi hayatın birbirini tamamlayan iki yaşamsal unsurlarıdır. Bilim, mütevazı bir araştırma faaliyetidir ve sınırlı sayıda örneklem ile genellemeler yaparak geçici bilgi verir. Pozitivistlerin, bilimi her şeyin ölçütü yapmaları ve duyu sınırlarının dışında kalan konuları yok saymaları yanlıştır. Tanrı, mucize, ahiret, ruh gibi dini kavramlar deneysel araştırmalara konu olamaz. Bilim bir mucizeyi ispatlayamaz veya çürütemez. Bu makale Peirce’ün din felsefene dair görüşlerini makale formatında ele almayı amaçlamaktadır.

Charles Sanders Peirce argues for God's reality instead of God's existence. He states that reality is a broader concept that encompasses being (existence). God is with man and religion is a totality of beliefs derived from human experience. The institutionalization of religion (such as church organization) harms the living, dynamic religion and undermines the unity and complementarity of science and religion. In fact, science and religion are like two halves of the same apple, two vital elements of life that complement each other. Science is a modest research activity and provides temporary information by making generalizations with a limited number of samples. It is wrong for positivists to make science the criterion for everything and to ignore matters beyond the limits of the senses. Religious concepts such as God, miracles, the afterlife and the soul cannot be the subject of empirical research. Science cannot prove or disprove a miracle. This article aims to discuss Peirce's views on the philosophy of religion in an essay format.
Perceptions of Corporate Social Responsibility in a Post-Disaster Context: The Impact of CSR on Employee Trust and Identification
Authors: Cogswell Joshua E. , Adams Caleigh
Published: August 2023

Corporate social responsibility (CSR) has become increasingly recognized for being a source of positive organizational outcomes. More specifically, CSR has been positively associated with employees experiencing higher levels of organizational trust and organizational identification. The purpose of this study was to examine the relationship among these variables in a post-disaster context – the aftermath of Hurricane Ida. In such conditions, employers’ CSR actions may be particularly salient to employees’ perceptions of and attitudes toward their organization. Based on a set of quantitative and qualitative survey data in a sample of South Louisiana employees, our study finds evidence that organizations’ CSR actions directed toward employees may be a stronger influence on employee trust and identification than actions taken to help the community. Implications for theory and practice and directions for future research are discussed.
Poker logaritma (pokema) sebagai media belajar memahami logaritma
Authors: Rini Utami  , Nurina Hidayah  , Dewi Azizah  , Amalia Fitri  , Sayyidatul Karimah  , Falah Muhammad
Published: August 2023

Permasalahan yang dihadapi siswa pada materi logaritma yaitu siswa kurang memahami sifat-sifat logaritma untuk menyelesaikan soal logaritma sehingga diperlukan media agar mempermudah siswa mempelajari materi tersebut. Pengabdian kepada masyarakat ini bertujuan untuk memberikan pendampingan belajar logaritma kepada siswa dengan menggunakan media Pokema. Media Pokema merupakan media pembelajaran matematika yang terdiri dari petunjuk penggunaan, materi logaritma, kartu-kartu berisi soal-soal logaritma dan kunci jawaban. Peserta kegiatan ini adalah siswa MA Tholabudin Masin berjumlah 20 orang. Pengabdian kepada masyarakat ini menggunakan metode Service Learning yang terdiri dari 4 tahap yaitu tahap investigasi dan perencanaan, tindakan, refleksi, dan demontrasi. Hasil dari kegiatan pengabdian ini yaitu rata-rata kemampuan siswa pada materi logaritma berbeda sebelum dan sesudah diberikan pendampingan. Selain itu sebanyak 85% siswa berpendapat media pokema menarik minat siswa untuk belajar logaritma.
Saving Private Macrophage
Authors:   , Cecotto Leonardo
Published: August 2023

Breaking a bone is not a pleasant experience. It might get worse if an implant is needed to repair the fracture. In 1 to 5% of the cases, Staphylococcus aureus might use the implant to enter and colonize our organism. This pathogenic bacterium is extremely difficult to kill due to its resistance to common antibiotic treatments. We need to find new therapeutic strategies to prevent S. aureus from entering and surviving inside our bodies.
Nature provided means to combat pathogenic bacteria even before antibiotic discovery: our immune system is an example. In the context of implant-associated infections, macrophages are a key immune cell type that coordinates the healing process while defending our organism from external threats. As this is already a lot of work, they need extra help to protect us from threats as dangerous as S. aureus. In this work, we aim to support macrophages in their fight against pathogens by increasing their antibacterial functions.
We tried to stimulate macrophages with several compounds known for their antibacterial properties, such as silver ions and nanoparticles, host defense peptides, and S. aureus-specific antibodies. Unfortunately, none of these strategies alone succeeded in helping macrophages eliminate all bacteria. However, a combination of those, might hold the key to successful therapy.
In conclusion, we focused on one cell type. However, implant-associated infections represent a complex scenario, with multiple players involved and all in need of help. Saving macrophages might help us win the fight, but not the war against S. aureus infections.
Pengujian Infusa Rebusan Bunga Telang (Clitoria ternatea) Sebagai Pewarna Alami Sediaan Apus Darah Tepi (SADT)
Authors: Husen Fajar , Nur Aini Hidayah Khasanah
Published: August 2023

Telang flower (Clitorea ternatea) is a flower that belongs to the endemic plants that are often found in Ternate. C. ternatea belongs to the Fabaceae family of leguminous plants and is the world's most prominent family of flowering plants. C. ternatea contains a lot of blue pigments or cyanos known as anthocyanins. These dyes have great potential as alternative dyes to replace methylene blue and are potential blood cell dyes. This study aimed to examine the potential of the anthocyanin content in the butterfly pea flower infusion as a natural differential dye for erythrocytes and leukocytes. This research method is descriptive in nature, in which the results of making cytological preparations in the form of capillary smears of human blood are stained with butterfly pea flower infusion at a concentration of 10%. The stained spots were then observed using a light microscope at 400x magnification. The colouring results of butterfly pea flowers were compared with a standard dye, Giemsa dye. The results showed that a 10% concentration of butterfly pea flowers stained erythrocytes but did not stain leukocytes well, while Giemsa's staining significantly stained well. The results also showed that butterfly pea flower infusion could only differentiate stained erythrocytes and unstained leukocytes but could not differentiate the types of leukocytes. Further research can be carried out by extracting anthocyanins from butterfly pea flowers and fractionating them to isolate single anthocyanin compounds that can potentially be dyed.
PENGEMBANGAN BAHAN AJAR BERBANTUAN MICROSOFT SWAY UNTUK MENINGKATKAN PEMAHAMAN KONSEP DAN KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK DALAM PEMBELAJARAN DARING
Authors: Sitours Barita Riana , Yani T Ahmad , Yundari Yundari , Zubaidah Zubaidah , Hamdani Hamdani
Published: August 2023

The ability to understand concepts and critical thinking skills of students in Indonesia is still relatively low and teaching materials play an important role in the learning process. This development research aims to produce teaching materials with Microsoft Sway that contain line and angle material, that was feasible to implement and effective for increasing students' conceptual understanding and critical thinking skills in online learning. The development of teaching materials is carried out by following the ADDIE method, namely analysis, design, development, implementation and evaluation. The teaching materials that have been developed are then validated by 2 media experts and 2 material experts. Teaching materials that have been validated are then tested individually (3 students) and tested on a limited group (30 students). The data in this study were obtained from response questionnaires and the results of the students' pre-test and post-test. This study produced teaching materials with Microsoft Sway that contain line and angle materials which were tested to be very feasible to implement with an average feasibility test score by material experts of 3.76 and an average feasibility score by media experts of 3.63. In addition, teaching materials with Microsoft Sway are also effective for increasing students' conceptual understanding and critical thinking skills, as evidenced by the gain score obtained based on the results of the pre-test and post-test of 0.67 which is included in the medium category and classically 86.67% of students get post-test scores that meet the minimum completeness criteria.
PENGARUH MOTIVASI BELAJAR TERHADAP HASIL BELAJAR PADA SISWA KELAS XI SMA NEGERI 73 JAKARTA
Authors: Parulian Siagian Daniel Dongan , Purba Santri Chintia , Simbolon Kerdid
Published: August 2023

Education plays an important role in the development of science and technology by creating skilled human resources. In learning activities, motivation and of course the learning outcomes themselves cannot be separated. Experts say that good learning outcomes are influenced by high motivation. The purpose of this research is to find out whether there is influence between students' learning motivation and student learning outcomes. This research was conducted at SMA Negeri 73 Jakarta Class XI in the even semester of the  academic year. This study uses a survey method to find the relationship between variables with a simple linear regression technique. Sampling used was purposive sampling, amounting to 150 students. Instruments in the form of a questionnaire / questionnaire learning motivation and daily test scores of all students of class XI. Based on the results of the hypothesis test, it is known that there is an influence between the learning motivation variable on the learning outcomes of class XI students in the compulsory mathematics subject at SMA Negeri 73 Jakarta. The results showed that the simple regression model can be used to predict learning motivation variables on learning outcomes, or there is an effect of learning motivation variables (X) on learning outcomes (Y), with a significance level of 0.000 < 0.05.
A Spotlight on Friedreich Ataxia: Optimising the Patient Journey from Diagnosis to Disease Management
Authors: Anheim Mathieu , Giunti Paola , Humphry Nicola
Published: August 2023

This symposium was held on the first day of the European Academy of Neurology (EAN) Congress, with four main objectives: to raise awareness of Friedreich ataxia (FA) as a rare, progressive neurodegenerative disorder; to summarise the patient journey from identifying first symptoms in childhood and adolescence to reaching an accurate diagnosis; to discuss the burden of living with FA and highlight the benefit of improved communication and collaboration between members of the multidisciplinary team on reducing this burden on patients and their caregivers; and to summarise current management options within the field of FA and provide an overview of emerging therapies and active clinical trials.

The symposium was chaired by Sylvia Boesch, a neurologist and senior staff member at the Medical University of Innsbruck, Austria, and Head of the Centre for Rare Movement Disorders, Innsbruck, Austria, who presented an overview of rare diseases in general and of FA. Mathieu Anheim, a neurologist at the Movement Disorders Unit, University Hospital of Strasbourg, France, followed with a description of the aetiology and symptomatology of FA. Lastly, Paola Giunti, a professorial research associate in the Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK, explained the best approach to FA management, including a summary of clinical trials for emerging therapies in FA.
Geleneksel ve Mobil Yöntemlerle Çizim Yapan Çocukların Çizim Becerileri Üzerine Bir Araştırma
Authors: HİÇYILMAZ Yahya
Published: August 2023

Bu araştırmanın temel amacı, 6-8 yaş aralığındaki çocukların geleneksel yöntem (kâğıt) ve mobil uygulamalar aracılığıyla gerçekleştirdikleri basit çizim etkinliklerinin incelenmesidir. Tarama yöntemi kullanılarak yapılan araştırmada, ilkokul birinci ve ikinci sınıflarda öğrenim gören ve araştırmaya gönüllü olarak katılmayı kabul eden 108 çocuk çalışma grubu olarak seçilmiştir. Veri toplama aracı olarak, A4 boyutunda beyaz resim kâğıdı ve çizim uygulaması yüklü mobil cihazlar üzerinde gerçekleştirilen çizimler kullanılmıştır. Toplanan veriler McNemar testi ve bağımlı örneklemler için t-testi yöntemleriyle analiz edilmiştir. Analiz sonuçları, çocukların geleneksel yöntem ve mobil uygulama kullanarak gerçekleştirdikleri çizimler arasında çizim becerileri açısından istatistiksel olarak anlamlı farklılıklar olduğunu ortaya koymuştur. Çizimlerdeki nesne sayısı puanlarına göre, geleneksel yöntemle çizilen resimlerin mobil uygulama ile çizilen resimlere kıyasla anlamlı düzeyde farklılaştığı gözlemlenmiştir. Ayrıca, geleneksel yöntemle çizilen resimlerin renk çeşidi puanları, mobil uygulama ile çizilen resimlerin renk çeşidi puanlarından anlamlı düzeyde farklılık göstermiştir. Bu araştırmanın sonucunda, çocukların geleneksel yöntem ve mobil uygulama kullanarak gerçekleştirdikleri çizimler arasında farklılıklar olduğu ortaya konmuştur. Ancak, bu farklılıkların daha iyi anlaşılabilmesi için daha fazla araştırma yapılması önerilmektedir.
THE EFFECTIVENESS OF DEBT RULE ON FISCAL SUSTAINABILITY: DO MACROECONOMIC DATA MATTER?
Authors: Malik Cahyadin  , Tamat Sarmidi and Norlin Khalid  , Siong Hook Law
Published: August 2023

The effectiveness of the debt rule to achieve a certain level of public debt and debt sustainability targets is one of the fiscal sustainability discussed in the literature. The current study attempts to estimate the impact of the debt rule on fiscal sustainability indicators for 77 countries during 1985 - 2018. There are two existing indicators are widely utilized cover primary gap and recursive algorithm. To deal with the potential of a random walk of the variables, the two-step system generalized method of moment (GMM) estimator is employed. Specifically, the current study constructs a new fiscal sustainability indicator by incorporating financial technology (FinTech) using principal component analysis (PCA) for 67 countries in 2014 and 2017. The new indicator is the main contribution on the existing literature of fiscal sustainability. The findings reveal that the debt rule has a positive and significant impact on the primary gap, either in the short- or medium-term, implying that the debt rule is effective in encouraging fiscal sustainability. Conversely, it has a negative and significant impact on the recursive algorithm. Similarly, this rule significantly contributes on the new indicator by incorporating FinTech. Therefore, policymakers are challenged to conduct this rule as a key fiscal rule in fiscal sustainability policy. The policymakers should also take more attention to increase the level of FinTech to guarantee fiscally sustainable level.
THE IMPACT OF BANKING RELATIONSHIP ON FIRM PERFORMANCE: EVIDENCE FROM HO CHI MINH STOCK EXCHANGE, VIETNAM
Authors: Khuu Thi Phuong Dong  , Nguyen Thi Ngoc Hoa  , Tran Cong Hiep  , Tran Viet Thanh Truc
Published: August 2023

This study aimed to investigate how close banking relationships affect Vietnamese public listed firms’ financial performance based on the empirical evidence of 172 companies listed on Ho Chi Minh City Stock Exchange in the period 2017 – 2019. Regression models, including Pooled Ordinary Least Square (OLS), Fix Effects Model (FEM) and Random Effects Model (REM) were explored to test the proposed hypotheses. The results indicated that banking relationships have advantages that outweigh disadvantages, which brings a positive impact on firm performance. These results suggested that firms should pay attention to the quality of the banking relationships instead of seeking for negotiation power and diversity in sources of funds.
HERDING BEHAVIOR IN VOLATILE MARKET REGIMES: AN IN-DEPTH ANALYSIS OF COINS, TOKENS, PANDEMIC, PENNY, AND PRICEY CRYPTOCURRENCIES
Authors: Rayenda Khresna Brahmana  , Muhammad Arsalan Hashmi  , Abdullah  , Josephine Tan-Hwang Yau
Published: August 2023

This study comprehensively analyzes herding behavior in the cryptocurrency market. First, we conduct an in-depth investigation of herding behavior in the overall cryptocurrency market. Second, we form several groups of cryptocurrencies according to their characteristics and analyze whether each group behaves similarly in volatile market regimes. Third, we investigate whether herding existed in each cryptocurrency group before and during the COVID-19 pandemic. Using a sample of 227 cryptocurrencies constituting nearly 95% of market capitalization, we reveal that herding behavior was absent in the overall sample and sub-samples comprising cryptocurrency groups. Further, the anti-herding behavior implies a contrarian response to the crowd. This anti-herding can be explained from two views: rational behavior of taking profit from market irrationality and irrational behavior due to fear or recency bias.
K-WAVE FANS AND NON-FANS: CULTURE-SPECIFIC AND COLLECTIVE RESPONSES TO KOREAN COUNTRY AND PRODUCT IMAGE
Authors: Robert Jeyakumar Nathan  , Soekmawati  , So Won Jeong  , Byoungho Ellie Jin
Published: August 2023

Purpose – Malaysia is a multicultural society, comprising ethnic Malays, Chinese, Indians, and other ethnic minorities. Its culture has complex interactions among multicultural and multi-lingual people, with diverse faiths and religions. This study investigates how a multicultural and multi-religious society responds to the influx of Korean products in the market and explores the differences in responses between fans and non-fans of the Korean Wave.Design/Methodology – Using the Online Focus Group Discussions (FGD) technique, qualitative research was conducted with ten participants to investigate multicultural Malaysians’ response to Korean country and product image.Findings – Through questions asked during the FGDs, themes that explain Malaysians’ perceptions of the Korean country image, Korean culture, and Korean products were identified. “Valuing relationship”, “Asian compatibility”, “natural and authentic”, “creativity and innovation”, “projection of boldness and confidence”, “cautious followers”, and “protective and caring culture” were primarily identified, representing positive attributes; “cosmetic surgery” was viewed negatively.Originality/value – Studies about the influence of culture and religion on Malaysian consumers’ responses toward Korean products are scarce. The findings of this study would provide insights into Malaysian consumers from diverse ethnic, cultural, and religious backgrounds. Understanding how foreign products enter and remain successful in a country like Malaysia could provide valuable insights to other countries and SMEs planning to enter new multicultural markets.
THE VALIDITY OF SCIENTIFIC LITERACY-BASED LKPD INTEGRATED VERSES OF THE QURAN WITH LIGHT MATERIAL FOR MTS STUDENTS
Authors: Indana Fitriyati Maghfiroh  , Noer Afâ€™idah
Published: August 2023

21st century education requires students to master 4C skills (creativity, critical thinking, collaboration, communication). Learning indicators with mastery of 4C skills can be obtained through the development of student worksheets (LKPD) based on integrated scientific literacy of Al Quran verses. One of the scientific literacy-based learning related to real life is the material of light. This research is a development research. The purpose of this study is to describe the process and result of developing LKPD based on integrated scientific literacy of Al Quran verses based on validity tests. In this LKPD development research, using the ADDIE development model (Analysis, Design, Development, Implementation, Evaluation) without using the implementation stage. After being developed, LKPD based on integrated scientific literacy of Al Quran verses were validated by expert validators, namely media expert lecturers, material expert lecturers, and science teachers. Data analysis used quantitative descriptive. The result of the LKPD validation assessment based on scientific literacy integrated verses of the Al Quran on light material obtained an average score of 3,84 including the very valid category. Based on the result of this study, the scientific literacy-based LKPD integrated verses of the Al Quran on light material developed has been declared feasible to be applied during the learning process.
La cardio-oncología como una visión multidisciplinaria en el enfoque y tratamiento de la patología oncológica contemporánea.
Authors: Lara Terán Joffre
Published: August 2023

Introducción: Las enfermedades cardiovasculares son la principal causa de muerte en el mundo, y las enfermedades oncológicas están aumentando en prevalencia. Los medicamentos oncológicos pueden tener efectos secundarios cardiovasculares, y la cardiooncología es una subespecialidad de la cardiología que se ocupa de la prevención y el tratamiento de las complicaciones cardiovasculares relacionadas con el cáncer.

Puntos importantes del editorial: Las antraciclinas son un grupo de medicamentos oncológicos que pueden causar cardiotoxicidad, lo que puede causar una variedad de síntomas, incluyendo fatiga, disnea, edema y dolor en torácico. En casos graves, la cardiotoxicidad puede provocar insuficiencia cardíaca. Otros medicamentos oncológicos que pueden causar cardiotoxicidad incluyen los anticuerpos anti-HER2, el fluorouracilo y la gemcitabina. Los inhibidores de la tirosinkinasa y los inhibidores del factor de crecimiento derivado del endotelio también pueden causar problemas cardiovasculares, como hipertensión, formación de coágulos sanguíneos y arritmia. Los pacientes con cáncer también tienen un mayor riesgo de desarrollar complicaciones tromboembólicas venosas en miembros inferiores.

Conclusión: El diagnóstico temprano y el tratamiento de las complicaciones cardiovasculares relacionadas con el cáncer son esenciales para mejorar la supervivencia de los pacientes con cáncer. La cardiooncología es una especialidad emergente y multidisciplinaria que requiere la participación de oncólogos, hematólogos, radiooncólogos y cardiólogos. El equipo de cardiooncología trabaja en conjunto para evaluar el riesgo cardiovascular de los pacientes con cáncer, prevenir las complicaciones cardiovasculares y tratar las complicaciones cardiovasculares que ocurren.
Evolutionary analysis of actinins(ACTN) gene family for positive selective sites by finding the dn/ds (ω) value
Authors: Din Ihsan Ud , Sun Li , Hu Lina
Published: August 2023

Identifying positively selected amino acid sites is an important approach for making a conclusion about the function of proteins; an amino acid site that is undergoing positive selection is likely to play a key role in the function of the protein. Here, we used codon-based substitution models and maximum-likelihood (ML) methods to identify positively selected sites that are likely to influence the cohesiveness and mechanics of the cytoskeleton by cross-linking actinins filaments and other cytoskeleton components to create a scaffold that imparts stability and forms a bridge between the cytoskeleton and signaling pathways. We use MEGA 7 and PAML for polygenetic Analysis and positive selective Sites. Alpha-actinins from skeletal muscle as a protein factor promoting the super precipitation of actomyosin and inducing the gelation of F-actin solutions. The protein is located in Z-bands of sarcomeres in skeletal and cardiac muscles as well as near the fascia adherents of intercalated discs in cardiac muscle. In smooth muscle, it exists in cytoplasmic dense bodies and membrane-associated dense plaques. We used PAMLX to find out specific sites in these DNA sequences.  These results show the location and identification of positively selected sites in the ACTININS gene family. ACTN1, ACTN2, ACTN3 and ACTN4 had (248G,250L), (234I,236N ,238P, 239K, 252F, 260E, 261Q, 314Q, 590N, 607L, 869S), (NO) and (248G, 250L) positive selective sites respectively. The aims of our work are the prediction of these sites to find the specific location of these sites in 3D structure and to replace it with suitable amino acids for the cure of obesity, muscles, cancer, and other chronic diseases
Hubungan Self-Efficacy Dengan Minat Berwirausaha Pada Mahasiswa Kebidanan
Authors: Rosdianto Nuur Octascriptiriani
Published: August 2023

Sedikitnya lapangan pekerjaan tersedia saat ini menggambarkan pentingnya pemberianilmu kewirausahaan bagi lulusan bidan. Salah satu upaya agar mahasiswa tergerakberwirausaha adalah menumbuhkan minat mahasiswa dalam berwirausaha. Faktoryang mempengaruhi minat berwirausaha pada mahasiswa adalah self-efficacy. Tujuandan manfaat penelitian mengetahui hubungan self-efficacy dengan minat berwirausahapada mahasiswa kebidanan dengan manfaat menambah wawasan terkait kewirausahaqanpada mahasiswa yang dikaitkan dengan self efficacy. Penelitian korelasional denganpendekatan secara cross-sectional. Populasi adalah mahasiswa Prodi Diploma IIIKebidanan STIKes Sukabumi sebanyak 106 responden, jumlah sampel sebanyak 50responden. Teknik pengambilan sampel yang digunakan yaitu purposive sampling.Instrumen yang digunakan pada variabel self-efficacy yaitu menggunakan General Self-Efficacy (GSES), dan pada minat berwirausaha menggunakan Zaidatol Akmaliah LopePihie Scale dengan hasil uji validitas mengacu kepada hasil instrument baku General Self-Efficacy (GSES), dan Zaidatol Akmaliah Lope Pihie Scale. Analisis data pada penelitianini menggunakan teknik chi-square. Hasil penelitian sebagian besar responden sebanyak40 responden (80%) memiliki self-efficacy tinggi dan sebagian besar responden sebanyak36 responden (72%) memiliki minat berwirausaha tinggi. Terdapat hubungan antaraself-efficacy dengan minat berwirausaha (p=0,012). Simpulan menunjukkan terdapathubungan signifikan self-efficacy dengan minat berwirausaha. Diharapkan workshopterkait peningkatan minat berwirausaha dapat terselenggara pada mahasiswa kebidanan
Gpr18 agonist dampens inflammation, enhances myogenesis, and restores muscle function in models of Duchenne muscular dystrophy
Authors: Dort Junio , Orfi Zakaria , Fiscaletti Melissa , Campeau Philippe M. , Dumont Nicolas A.
Published: August 2023

Introduction: Muscle wasting in Duchenne Muscular Dystrophy is caused by myofiber fragility and poor regeneration that lead to chronic inflammation and muscle replacement by fibrofatty tissue. Our recent findings demonstrated that Resolvin-D2, a bioactive lipid derived from omega-3 fatty acids, has the capacity to dampen inflammation and stimulate muscle regeneration to alleviate disease progression. This therapeutic avenue has many advantages compared to glucocorticoids, the current gold-standard treatment for Duchenne Muscular Dystrophy. However, the use of bioactive lipids as therapeutic drugs also faces many technical challenges such as their instability and poor oral bioavailability.

Methods: Here, we explored the potential of PSB-KD107, a synthetic agonist of the resolvin-D2 receptor Gpr18, as a therapeutic alternative for Duchenne Muscular Dystrophy.

Results and discussion: We showed that PSB-KD107 can stimulate the myogenic capacity of patient iPSC-derived myoblasts in vitro. RNAseq analysis revealed an enrichment in biological processes related to fatty acid metabolism, lipid biosynthesis, small molecule biosynthesis, and steroid-related processes in PSB-KD107-treated mdx myoblasts, as well as signaling pathways such as Peroxisome proliferator-activated receptors, AMP-activated protein kinase, mammalian target of rapamycin, and sphingolipid signaling pathways. In vivo, the treatment of dystrophic mdx mice with PSB-KD107 resulted in reduced inflammation, enhanced myogenesis, and improved muscle function. The positive impact of PSB-KD107 on muscle function is similar to the one of Resolvin-D2. Overall, our findings provide a proof-of concept that synthetic analogs of bioactive lipid receptors hold therapeutic potential for the treatment of Duchenne Muscular Dystrophy.
Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids
Authors: González Ricelia , Murillo-López Juliana , Rabanal-León Walter , Prent-Peñaloza Luis , Concepción Odette , Olivares Pedro , Duarte Yorley , de la Torre Alexander F. , Gutiérrez Margarita , Caballero Julio
Published: August 2023

Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines. Thus, through the Passerini and Ugi multicomponent reactions (P-3CR and U-4CR), we obtained thirteen depsipeptides and peptoids in moderate to high yield following the established protocol and fundamentally varying the electron-rich carboxylic acid as reactants. UV/Vis spectroscopy was utilized to study the photophysical properties of the newly synthesized compounds. Differences between the carbonyl-substituted chromophores cause differences in electron delocalization that can be captured in the spectra. The near UV regions of all the compounds exhibited strong absorption bands. Compounds P2, P5, U2, U5, and U7 displayed absorption bands in the range of 250–350 nm, absorbing radiation in this broad region of the electromagnetic spectrum. A photostability study for U5 showed that its molecular structure does not change after exposure to UV radiation. Fluorescence analysis showed an incipient emission of U5, while U6 showed blue fluorescence under UV radiation. The photophysical properties and electronic structure were also determined by TD-DFT theoretical study.
Social media use and mental health in deaf or hard-of-hearing adults—Results of an online survey
Authors: Schäfer Karolin , Miles Felix
Published: August 2023

This paper presents the results of an online survey on digital participation through the use of social media ofn= 38 German deaf or hard-of-hearing (DHH) adults. In addition, information about the respondents' mental health is collected with four different scales: the Rosenberg Self-Esteem Scale (RSES), the Fear of Missing Out Scale (FoMoS), the Patient-Reported Outcomes Measurement Information System Social Isolation Scale (PRO-MIS SI-S) and the Social Media Disorder Scale (SMDS). Correlation analyses using Pearson correlation and Spearman rank correlation tests were conducted to identify relationships between mental health and use of social media. The results indicate that the DHH adults have 4.13 social media accounts on average and use social media 3.78 h per day. This is consistent with other research findings, so that the DHH individuals in this study do not differ from other DHH adults or hearing adults in the number of their social media accounts and in their media usage time. However, there are differences in usage of social media that concern, for example, the social media platforms that are used and time of usage due to communication modality (spoken language, sign language, bimodal bilingualism, and mixed forms). DHH individuals who use sign language use social media less overall compared to DHH people who use spoken language. In terms of mental health, it was found that, as expected, addictive social media behavior and high usage time are interrelated. Addictive behavior, in turn, is often associated with low self-esteem, a sense of social isolation, and a fear of missing out. In general, many participants in the study score high in scales for self-perception of social isolation and loneliness. Nevertheless, there are also positive effects and opportunities of using social media, especially in terms of digital participation, for DHH people, which are also discussed in the article.
Projected distribution of the westernmost subpopulation of Assamese macaques (Macaca assamensis pelops) under climate change: conservation implications of a threatened population
Authors: Khanal Laxman , Upadhyaya Laxmi Prasad , Pandey Naresh , Chand Dhirendra Bahadur , Karki Melina , Chalise Mukesh Kumar , Kyes Randall C.
Published: August 2023

Anthropogenic climate change can have a negative impact on the distribution of habitat specialist species with narrow distributional ranges. Among the many areas around the world affected by climate change, the Himalayan region in particular is experiencing marked effects of global warming on its climatic patterns and life forms. This study assessed the current distribution of Assamese macaques (Macaca assamensis) in western Nepal, and projected their likely distribution (via habitat suitability modeling) for the years 2050 and 2070 under the two most plausible greenhouse gas emission scenarios (RCP4.5 and RCP6.0). We recorded a total of 159 Assamese macaques belonging to 10 groups (nine of them residing outside of protected area networks) between 684m and 2550m asl in western Nepal. Climatic niche modeling predicted that 37.03% (25,114 km2) of the total area of western Nepal (67,813 km2) represented suitable habitat of the species, the majority of which ranged between 1000 m and 2000 m asl. Future projections of the current climatic niche of the Assamese macaques revealed a consistent decrease in the suitable habitat for 2050 and 2070 in both of the greenhouse emission scenarios tested. With the RCP6.0 scenario, almost 57% of the current highly suitable habitat would be lost by 2070 with remaining suitable habitat shifted towards higher elevations. The loss of habitat directly affects the species survival and the range shift towards higher elevation exposes them to new areas for conflict with humans. Therefore, the Assamese macaque population in western Nepal requires a high conservation priority with the establishment of new protected areas.
Imaging characterization of myocardial function, fibrosis, and perfusion in a nonhuman primate model with heart failure-like features
Authors: Liu Xing-Li , Wang Guan-Zhong , Rui Mao-Ping , Fan Dong , Zhang Jie , Zhu Zheng-Hua , Perez Rosario , Wang Tony , Yang Li-Chuan , Lyu Liang , Zheng Jie , Wang Gang
Published: August 2023

Introduction

The availability of a human-like chronic heart failure (HF) animal model was critical for affiliating development of novel therapeutic drug treatments. With the close physiology relatedness to humans, the non-human primate (NHP) HF model would be valuable to better understand the pathophysiology and pharmacology of HF. The purpose of this work was to present preliminary cardiac image findings using echocardiography and cardiovascular magnetic resonance (CMR) in a HF-like cynomolgus macaque model.

Methods

The NHP diet-induced model developed cardiac phenotypes that exhibited diastolic dysfunction with reduced left ventricular ejection fraction (LVEF) or preserved LVEF. Twenty cynomolgus monkeys with cardiac dysfunction were selected by echocardiography and subsequently separated into two groups, LVEF < 65% (termed as HFrEF, n = 10) and LVEF ≥ 65% with diastolic dysfunction (termed as HFpEF, n = 10). Another group of ten healthy monkeys was used as the healthy control. All monkeys underwent a CMR study to measure global longitudinal strain (GLS), myocardial extracellular volume (ECV), and late gadolinium enhancement (LGE). In healthy controls and HFpEF group, quantitative perfusion imaging scans at rest and under dobutamine stress were performed and myocardial perfusion reserve (MPR) was subsequently obtained.

Results

No LGE was observed in any monkey. Monkeys with HF-like features were significantly older, compared to the healthy control group. There were significant differences among the three groups in ECV (20.79 ± 3.65% in healthy controls; 27.06 ± 3.37% in HFpEF group, and 31.11 ± 4.50% in HFrEFgroup, p < 0.001), as well as for stress perfusion (2.40 ± 0.34 ml/min/g in healthy controls vs. 1.28 ± 0.24 ml/min/g in HFpEF group, p < 0.01) and corresponding MPR (1.83 ± 0.3 vs. 1.35 ± 0.29, p < 0.01). After adjusting for age, ECV (p = 0.01) and MPR (p = 0.048) still showed significant differences among the three groups.

Conclusion

Our preliminary imaging findings demonstrated cardiac dysfunction, elevated ECV, and/or reduced MPR in this HF-like NHP model. This pilot study laid the foundation for further mechanistic research and the development of a drug testing platform for distinct HF pathophysiology.
High-resolution record of temporal change in organic matter burial over the past ∼8,600 years on the northwestern continental slope of the South China Sea
Authors: Tong Gang , Chen Lilei , Zhang Guangxu , Liu Jian , Chen Bin , Xu Gang , Liu Ming , An Yuhui , Chen Duanxin
Published: August 2023

Sedimentary organic matter (SOM) on continental slopes in marine regions can sensitively record climatic and environmental changes. In this study, total organic carbon content (TOC), total nitrogen content (TN), and their stable isotope compositions (δ13C and δ15N) for sediments of core G02 were investigated (at ∼24.2-year resolution) to reveal the temporal variations in organic matter sources and the main controls on the sources and distribution of buried organic matter on the northwestern continental slope of the South China Sea over the last ∼8600 years. Results of a δ13C binary mixing model reveal that ∼82.3 ± 3% of SOM is derived from marine autochthonous sources. We suggest that the carbon and nitrogen contents and compositions of SOM are governed by distinct factors. The more positive δ15N values before the Pulleniatina Minimum Event occurrence are ascribed to stronger subsurface water intrusion by the Kuroshio Current, which led to enhanced subsurface denitrification and in turn counteracted the effect of mixing with surface water caused by the East Asian winter monsoon. Sedimentary δ13C values show a fluctuant decrease during ca. 8.6–3.0 cal kyr BP and a conspicuous increase during ca. 3.0–1.4 cal kyr BP. These changes are attributed to the decrease of marine productivity induced by the continuous weakening East Asian monsoon effect and the decrease of terrigenous organic carbon input induced by the weakened Indian summer monsoon precipitation, respectively. Since ca. 1.4 cal kyr BP, human activities have become the dominant factor in controlling the production and distribution of organic carbon. The results provide an important basis for understanding of source-sink processes of organic matter and the factors influencing these processes on continental slopes in low-latitude marginal seas.
Effects of ovarian stimulation protocols on outcomes of assisted reproductive technology in adenomyosis women: a retrospective cohort study
Authors: Ge Li , Li Yexing , Guan Shengnan , Cui Linlin , Chen Zi-Jiang
Published: August 2023

Objective

To evaluate the effects of different ovarian stimulation protocols on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile women with adenomyosis.

Methods

We carried out a retrospective cohort study among infertile women with adenomyosis receiving IVF/ICSI treatment, including 257 fresh embryo transfer (ET) cycles and 305 frozen embryo transfer (FET) cycles. In fresh ET cycles, ultra-long, long, short, and antagonist protocols were adopted. In FET cycles, patients received long-acting GnRH agonist (GnRHa) pretreatment or not. The primary outcome was clinical pregnancy rate (CPR), and the secondary outcomes included implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR).

Results

In fresh ET cycles, compared with ultra-long and long protocols, IR (49.7%, 52.1% versus 28.2%, P=0.001) and CPR (64.3%, 57.4% versus 35.6%, P=0.004) significantly decreased in the short protocol. Similarly, compared with ultra-long and long protocols, a decreased inclination of IR (49.7%, 52.1% versus 33.3%) and CPR (57.4%, 64.3% versus 38.2%) existed in the antagonist protocol, although no statistical significance was detected because of strict P adjustment of Bonferroni method (Padj=0.008). Compared with long protocol, LBR in short protocol decreased obviously (48.2% versus 20.3%, P<0.001). In FET cycles, no matter which origin of embryos, there were no statistical differences in IR, CPR, and LBR. For women ≥35 years receiving fresh ET, CPR was higher in ultra-long and long protocols (52.1%, 50.0% versus 20.0%, 27.5%, P=0.031) compared to antagonist and short protocols. For women ≥35 years receiving FET, compared with ultra-long and antagonist protocols, cycles with embryos originating from long and short protocols had higher proportions of long-acting GnRHa pretreatment (30.4%,30.00 versus 63.9%, 51.4%, P=0.009). IR (61.1%, 48.6% versus 32.6%, 25.0%, P=0.020) and CPR (58.3%, 48.6% versus 30.4%, 25.0%, P=0.024) in long and short protocols were higher than rates of ultra-long and antagonist protocols, but no statistical differences were supported because of strict Bonferroni method (Padj=0.008).

Conclusion

In infertile women with adenomyosis, if a fresh embryo was planned for transfer, an ultra-long or long protocol might be beneficial. If antagonist and short protocols were used, whole embryos frozen followed by FET was recommended. In FET cycles, embryos derived from different protocols had no impact on pregnancy outcomes.