Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US
Authors: Wong Christina G. , Miller Justin B. , Zhang Fan , Rissman Robert A. , Raman Rema , Hall James R. , Petersen Melissa , Yaffe Kristine , Kind Amy J. , O’Bryant Sid E. ,   HABS-HD Study Team, Ances Beau , Babulal Ganesh , Barber Robert , Barnes Lisa , Borzage Matthew , Braskie Meredith , Cheema Amrita , Christian Brad , Cohen Ann , Donohue Michael , Hall James , Johnson Leigh , Kind Amy , Large Stephanie , Lee Joe , Llibre-Guerra Jorge , Mapstone Mark , Mason David , Mielke Michelle , Nandy Rajesh , O'Bryant Sid , Okonkwo Ozioma , Palmer Ray , Petersen Melissa , Phillips Nicole , Raman Rema , Rissman Robert , Rivera Mindt Monica , Shi Yonggang , Toga Arthur , Vardarajan Badri , Vintimilla Raul , Yaffe Kristine , Zhang Fan , Zhou Zhengyang 
Published: August 2023

Importance

Understanding how socioeconomic factors are associated with cognitive aging is important for addressing health disparities in Alzheimer disease.

Objective

To examine the association of neighborhood disadvantage with cognition among a multiethnic cohort of older adults.

Design, Setting, and Participants

In this cross-sectional study, data were collected between September 1, 2017, and May 31, 2022. Participants were from the Health and Aging Brain Study–Health Disparities, which is a community-based single-center study in the Dallas/Fort Worth area of Texas. A total of 1614 Mexican American and non-Hispanic White adults 50 years and older were included.

Exposure

Neighborhood disadvantage for participants’ current residence was measured by the validated Area Deprivation Index (ADI); ADI Texas state deciles were converted to quintiles, with quintile 1 representing the least disadvantaged area and quintile 5 the most disadvantaged area. Covariates included age, sex, and educational level.

Main Outcomes and Measures

Performance on cognitive tests assessing memory, language, attention, processing speed, and executive functioning; measures included the Spanish-English Verbal Learning Test (SEVLT) Learning and Delayed Recall subscales; Wechsler Memory Scale, third edition (WMS-III) Digit Span Forward, Digit Span Backward, and Logical Memory 1 and 2 subscales; Trail Making Test (TMT) parts A and B; Digit Symbol Substitution Test (DSST); Letter Fluency; and Animal Naming. Raw scores were used for analyses. Associations between neighborhood disadvantage and neuropsychological performance were examined via demographically adjusted linear regression models stratified by ethnic group.

Results

Among 1614 older adults (mean [SD] age, 66.3 [8.7] years; 980 women [60.7%]), 853 were Mexican American (mean [SD] age, 63.9 [7.9] years; 566 women [66.4%]), and 761 were non-Hispanic White (mean [SD] age, 69.1 [8.7] years; 414 women [54.4%]). Older Mexican American adults were more likely to reside in the most disadvantaged areas (ADI quintiles 3-5), with 280 individuals (32.8%) living in ADI quintile 5, whereas a large proportion of older non-Hispanic White adults resided in ADI quintile 1 (296 individuals [38.9%]). Mexican American individuals living in more disadvantaged areas had worse performance than those living in ADI quintile 1 on 7 of 11 cognitive tests, including SEVLT Learning (ADI quintile 5: β = −2.50; 95% CI, −4.46 to –0.54), SEVLT Delayed Recall (eg, ADI quintile 3: β = −1.11; 95% CI, −1.97 to –0.24), WMS-III Digit Span Forward (eg, ADI quintile 4: β = −1.14; 95% CI, −1.60 to –0.67), TMT part A (ADI quintile 5: β = 7.85; 95% CI, 1.28-14.42), TMT part B (eg, ADI quintile 5: β = 31.5; 95% CI, 12.16-51.35), Letter Fluency (ADI quintile 4: β = −2.91; 95% CI, −5.39 to −0.43), and DSST (eg, ADI quintile 5: β = −4.45; 95% CI, −6.77 to –2.14). In contrast, only non-Hispanic White individuals living in ADI quintile 4 had worse performance than those living in ADI quintile 1 on 4 of 11 cognitive tests, including SEVLT Learning (β = −2.35; 95% CI, −4.40 to –0.30), SEVLT Delayed Recall (β = −0.95; 95% CI, −1.73 to –0.17), TMT part B (β = 15.95; 95% CI, 2.47-29.44), and DSST (β = −3.96; 95% CI, −6.49 to –1.43).

Conclusions and Relevance

In this cross-sectional study, aging in a disadvantaged area was associated with worse cognitive functioning, particularly for older Mexican American adults. Future studies examining the implications of exposure to neighborhood disadvantage across the life span will be important for improving cognitive outcomes in diverse populations.