bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMBINAAN DISIPLIN SISWA OLEH GURU DI SMK NEGERI 1 GUNUNG TULEH KABUPATEN PASAMAN BARAT
Authors: Wardi Ilham , Adi Nelfia
Published: July 2020

The purpose of this study was to obtain information about student discipline development by teachers at SMK Negeri 1 Gunung Tuleh, West Pasaman Regency as seen from 1) student disciplinary guidance by teachers through discipline, 2) student discipline development by teachers through exemplary governance, 3) coaching student discipline by the teacher through guidance, 4) student discipline development by the teacher through punishment, 5) student discipline development by the teacher through supervision.This study was a descriptive study. The total population in this study was 236 people. Samples were taken with Simple Random Samplingtechniquewith 70 people. The data collection tool used is a Likert scale model questionnaire with 5 alternative answers Questionnaires have been tested for validity and reliability. Data were analyzed using the average formula.The results of the study show that: 1) student discipline development by teachers through discipline is stated to be good with an average score of 3.69, 2) student discipline development by teachers through exemplary governance is stated to be quite good with an average score of 3.52, 3) student disciplinary guidance by the teacher through guidance expressed either with an average score of 3.65, 4) student discipline development by the teacher through punishment expressed both with an average score of 3.75, 5) student discipline development by the teacher through supervision expressed well with an average score 3.75. Overall, Student Discipline Development by Teachers at SMK Negeri 1 Gunung Tuleh, West Pasaman Regency is 3, 76 in the good category. This indicates that the discipline of student discipline by teachers at SMK Negeri 1 Gunung Tuleh, West Pasaman Regency is good, but it still needs to be maintained and improved again so that it increases in the excellent category.
PENGELOLAAN SISTEM INFORMASI MANAJEMEN DALAM MENINGKATKAN PRESTASI UJIAN AKHIR SEKOLAH(UAS) DI SD NEGERI 33 KALUMBUK KOTA PADANG
Authors: Afriyanli Hana Khairi
Published: July 2020

Education must have a clear vision and mission to produce quality output and be able to be optimally oriented today. In order to achieve the desires of educational institutions that can produce quality output, the quality and results of educational institutions need to be organized within the institution, in which there must be definite management. In conducting observations carried out using a descriptive qualitative approach. The data collection method used is interview. The intended results are the results of the UAS in 2018 which are expected to be above SKL determined by schools and by 2020 and can reach an average of 7.5. The results of the UAS include a minimum score and an average of 3 subjects (Indonesian Language, Mathematics, Science) with a target of 100% graduation rate and top 5 ranking at the sub-district level. The UAS Value target for 2020.
MENDESAIN PROSEDUR STANDAR PENGELOLAAN ARSIP KELEMBAGAAN
Authors: Rahayuningsih Fransisca , Hastutiningrum MM
Published: July 2020

Mutu sebuah lembaga salah satunya ditentukan oleh pengelolaan arsip yang baik. Arsip adalah rekaman kegiatan atau peristiwa dalam berbagai bentuk dan media sesuai dengan perkembangan teknologi informasi dan komunikasi yang dibuat dan diterima oleh lembaga negara, pemerintah daerah, lembaga pendidikan, perusahaan, organisasi politik, organisasi kemasyarakatan, dan perseorangan dalam pelaksanaan kehidupan bermasyarakat, berbangsa dan bernegara. Arsip yang tertata dengan baik, dapat sebagai memori kolektif sebuah lembaga dan bahkan dapat menjadi basis pengetahuan tentang identitas lembaga selain pertumbuhan dan perkembangan lembaga dapat diketahui secara pasti. Pustakawan adalah profesi yang dianggap mampu melakukan pengelolaan arsip mengingat ilmu perpustakaan dan ilmu kearsipan memiliki rumpun yang sama., selain adanya keterbatasan tenaga yang dimiliki sebuah lembaga. Dalam pengelolaan arsip kelembagaan didasarkan pada 4 pilar pengelolaan arsip, yaitu Pedoman Tata Naskah Dinas, Pedoman Pola Klasifikasi Arsip, Pedoman Jadwal Retensi Arsip dan Pedoman Keamanan dan Akses Arsip. Selanjutnya pustakawan dapat mendesain prosedur standar pengelolaan arsip dinamis, mendesain prosedur standar pengelolaan arsip statis dalam rangka akuisisi/pemindahan arsip statis.
TEKNOLOGI INFORMASI
Authors: Makmur Testiani
Published: July 2020

Makalah ini bertujuan mengulas teknologi informasi implikasi dan dan dampak bagi perpustakaan, pustakawan dan pemustaka. Metodologi berbasis studi literature yang berkaitan dengan teknologi informasi selanjutnya digunaan untuk menjelaskan implikasi dan dampaknya bagi perpustakaan, pustakawan dan pemustakan. Teknologi informasi impilikasi dan dampaknya bagi (1) Perpustakaan harus menyesuiakan diri supaya bisa berdampingan dengan teknologi informasi dengan mempersiapkan kebijakan, dana, Software, sistem jaringan, infrastruktur peralatan teknologi informasi, sumber daya manusia yang mampu mengoperasikan teknologi informasi, perlunya pelatihan teknologi bagi pustakawan dan user education bagi pemustaka serta harus menyediakan maupun mengembangkan layanan berbasis teknologi. (2) Agar selalu relevansi dengan kemajuan teknologi informasi dan mampu menjalan peran-peran baru pustakawan diperlukan dukungan keahlian yang meliputi literasi informasi, literasi digital dan literasi media. (3) Berimplikasi bagi pemustaka antaranya perlu user education, tersedianya e-resources, kemudahan mengakses informasi, dan dituntut memiliki keahlian literasi informasi.
Modeling of innovative activity management processes in the region with use of fuzzy cognitive maps
Authors: Vasilyev Vladimir , Chernyakhovskaya Liliya , Vulfin Alexey
Published: July 2020

The problem of analysis and management of innovative activity in the region on the example of organizing the Scientific and Educational Center (SEC) with use of cognitive modeling tools is considered. Based on the normative documents requirements, the fuzzy cognitive map (FCM) of the problem situation under consideration is constructed, with the help of which the expected values of the SEC target indicators and the effectiveness of the SEC functioning as a whole are estimated. It is shown that the use of the genetic algorithm at the stage of optimizing the FCM parameters allows us to obtain reasonable recommendations for improving the efficiency of SEC due to a more rational distribution of financial resources.
Doğal Florada Çimlenmiş Sekiz Farklı Salep Orkidesi Türünün İlk Yıl Gelişimlerinin Tanımlanması
Authors: KURT Dursun , ÇALIŞKAN Ömer
Published: July 2020

Yumrulu (terrestrial) orkideler, doğaya sayılamayacak kadar çok tohum bırakırlar. Orkide tohumlarında besi doku yoktur ve normal şartlarda çimlenmezler. Bu nedenle üretilemeyen türler arasındadır ve dünya genelinde koruma altına alınmıştır. Sadece mikorizalar ile simbiyotik ilişki kurabilen tohumlar çimlenebilirler. Çimlenen tohumların ise çiçek açması, tohum üretmesi uzun yıllar almaktadır. Bu çalışmada bazı salep türlerinin doğal ortamlarında çimlenmiş tohumları tespit edilmiş ve materyal olarak kullanılmıştır. Çimlenme yılı olarak tanımlanan ilk gelişim yılında, ele alınan türlerde, ilk yıl gelişim performansları yaprak sayısı, yaprak eni-boyu, yaş yumru eni-boyu, yaş yumru ağırlığı ve yaş biyokütle ağırlığı ile belirlenmiştir. Beş cinse ait sekiz türün incelendiği bu çalışmada çimlenme yılında 1-3 minik yaprak oluşumu gözlenmiş, toplam biyokütleleri ise bir gramdan daha az olmuştur. Geliştirdikleri yumruların taze ağırlıkları, türlere göre 0.06-0.31 gram arasında tespit edilmiştir. Veriler değerlendirildiğinde salep orkidelerinin çimlenme yılında minyatür bitkicikler olarak ilk yıl gelişimlerini tamamladıkları anlaşılmaktadır. Salep orkidelerinde, sorunlu çimlenme döneminden sonra, büyüme ve gelişmenin de yavaş gerçekleştiği görülmüştür.
Effects of Environmental Variations on Yield of Oriental Tobaccos
Authors: KURT Dursun , YILMAZ Güngör , KINAY Ahmet
Published: July 2020

The study was conducted to determine the impacts of environmental variations on yield and yield related properties of tobacco. The experimental layout was in the randomized blocks with three replicates in four different locations (Erbaa-Evciler, Erbaa-Karayaka, Gümüşhacıköy, Bafra) using 21 lines and four standard varieties that stand out with their different characteristics. The variation in plant height, number of leaves, leaf width, leaf length and leaf yield of genotypes were investigated at different ecologies. All the parameters investigated of the genotypes have been significantly affected by changing environmental conditions. Plant height ranged from 49.33 cm to 177.32 cm, the number of leaves from 21.83 to 47.10 per plant, leaf width from 6.83 to 16.31 cm, leaf length from 13.01 to 28.93 cm, and yield ranged from 79.17 kg-1 to 238.98 kg da-1. The results for the performances of genotypes in all environments showed that 5 lines (ERB-11, ERB-14, ERB-16, ERB-21, ERB-35) for plant height, 6 lines (ERB-6, ERB-7, ERB-11, ERB-14, ERB-16, ERB-35) for the number of leaves, 10 lines (ERB-9, ERB-16, ERB-17, ERB-18, ERB-19, ERB-21, ERB-25, ERB-26, ERB-27, ERB-30) for leaf width, 1 line (ERB-16) in for leaf length and 13 lines (ERB-6, ERB-7, ERB-9, ERB-13, ERB-16, ERB-18, ERB-19, ERB-21, ERB-25, ERB-27, ERB-30, ERB-35, ERB-38) for yield come to the fore.
Sakarya İli Fındık Bahçelerinde Fındık Kurdu (Curculio nucum L.) (Coleoptera: Curculionidae) ve Fındık Yeşil Kokarcası (Palomena prasina L.) (Hemiptera: Pentatomidae)’nın Zarar Oranlarının Belirlenmesi
Authors: ATEŞ Semra , KAÇAR Gülay
Published: July 2020

Bu çalışma Batı Karadeniz Bölgesi’nde yer alan Sakarya ili fındık bahçelerinde Fındık kurdu Curculio nucum L. (Colepotera: Curculionidae) ve Fındık yeşil kokarcası Palomena prasina L. (Hemiptera: Pentatomidae)’nın zarar oranlarını belirlemek amacıyla 2017-2018 yıllarında yürütülmüştür. Çalışmanın ilk yılı, Fındık kurdu’nun zararı nedeniyle oluşan delikli meyve %0.8-1.8 ve boş iç %8.2-11.5, ikinci yıl ise delikli meyve %0.0-0.2 ve boş iç %7.4-10 olarak bulunmuştur. İlk yıl, Fındık yeşil kokarcası zararı olan şekilsiz iç oluşumu %0.7-1.4 ve lekeli iç %0.5-1.1, ikinci yıl şekilsiz iç oluşumu %1.2-1.9 ve lekeli iç %0.7-1.3 olarak belirlenmiştir. Bu iki türün ortak zararı olan sarı karamuk ve kara karamuk yıllara göre sırasıyla %1.8-3.2 ve %13.5-21.9 olarak belirlenmiştir.
Armut Fidanlarının Morfolojik Özellikleri Üzerine Anaçların ve Çeşitlerin Etkisi
Authors: SERTTAŞ Sevgi , ÖZTÜRK Ahmet
Published: July 2020

Meyve yetiştiriciliğinde anaçlar üzerine aşılanan çeşidin büyüme ve gelişmesini etkilediği gibi çeşitler de üzerlerine aşılandıkları anacı etkilemektedirler. Günümüzde armut yetiştiriciliği farklı büyüme özelliklerine sahip anaçlar üzerine aşılanarak çoğaltılan fidanlar ile yapılmaktadır. Bitkilerin kök sistemini oluşturacak olan anaçların seçimi çeşit seçimi kadar önemlidir. Bu çalışma, aşılı armut fidanlarının morfolojik özellikleri üzerine bazı armut klon anaç ve çeşitlerinin etkisini belirlemek amacıyla 2018-2019 yılları arasında yürütülmüştür. Bu çalışmada, ‘Deveci’, ‘Williams’, ‘Santa Maria’ ve ‘Abate Fetel’ armut çeşitleri Fox9, Fox11, OHxF87 ve OHxF333 armut klon anaçları üzerine dilciksiz aşı yöntemiyle aşılanmıştır. Araştırmada fidanlarda anaç çapı (mm), aşı noktası çapı (mm), aşı sürgününde yan dal sayısı (adet), boğum sayısı (adet), boğum arası mesafe (cm), yaprak eni ve boyu (cm), yaprak sapı uzunluğu (cm) ve kalınlığı (mm), sürgündeki yaprak sayısı (adet), ortalama ve toplam yaprak alanı (cm2) incelenmiştir. Araştırmada tüm parametreler üzerine anaçların ve çeşitlerin değişen düzeylerde etkiye sahip olduğu saptanmıştır. En yüksek aşı noktası çapı anaçlar bakımından Fox9; çeşitler bakımından ‘Deveci’de belirlenmiştir. Araştırmada en fazla yan dal sayısı ve yaprak sayısı Fox9 üzerine aşılı ‘Deveci’ çeşidinde tespit edilmiştir. Ortalama yaprak alanı en fazla ‘Santa Maria’, bitki başına toplam yaprak alanı ise ‘Deveci’ çeşidinde belirlenmiştir. Sürgündeki boğum sayısının Fox9 anacında diğer anaçlardan daha yüksek olduğu belirlenmiştir. Boğum arası mesafenin Fox9 anacında diğer anaçlardan daha düşük olduğu saptanmıştır. ‘Santa Maria’ çeşidinde boğum arası mesafenin diğer çeşitlerden daha yüksek olduğu tespit edilmiştir. Bu araştırmanın sonucunda morfolojik özellikler bakımından Fox9 anacı üzerine aşılı ‘Deveci’ çeşidinin diğer çeşit/anaç kombinasyonlarından daha iyi değerlere sahip olduğunu söyleyebiliriz.
NEW PERSPECTIVES ON THE PRIORITIES AND CHALLENGES OF THE INTERNAL AUDIT FUNCTION
Authors: POP Ana Monica
Published: July 2020

In recent years, in the context of an increasingly dynamic economic environment, internal audit function knows an ascending trajectory as a consequence of the qualitative changes recorded following the application of a methodological and procedural framework appropriate to this activity. The present research highlights the priorities and the current challenges that the internal audit function faces in the Romanian space, but also worldwide faced in terms of expanding roles, emergence of new risks, grater stakeholder scrutiny and resourcing pressures. This scientific approach is made possible by using the information provided by the Institute of Internal Auditors through the Research Foundation of it, focused on Global Internal Audit Common Body of Knowledge (CBOK) 2015 Practitioner Survey in order to achieve a global perspective and a better understanding of stakeholders’ expectations of internal audit’ s purpose, function and performance and data documented following the opinion surveys of internal auditors conducted by KMPG and other specialist in the field - Deloitte, Protiviti.
JEL Classification: M42
Simulation two storey house of masonry wall under the earthquake load
Authors: H. Saeed Maan
Published: July 2020

The masonry wall building systems have high sensitivity against earthquakes and the fact that this system of construction is widespread in Iraq, especially condominiums. Iraq subjected to many earthquakes in recent years and is expected to be subjected to more intensities of earthquakes in the future engendered an urgent need to investigate the behavior of this type of construction under the influence of earthquakes. The analysis of two-storey house in this research paper was performed by the finite element package program ABAQUS. Model simulation with dimensions (5 * 20 m) from the common one and two-storey house models in Iraq. The compressive strength of bricks (17MPa) type A  and compressive strength of mortar(15MPa) with mixing ratio 1:3 was used to represented of the properties of construction materials in Iraq. The nonlinearity behavior of the materials is considered in this research paper. The model is subjected to PGA(0.5g) from  EL-Centro Earthquake (1940 N-S ) as input ground motion to determine its seismic performance compared the maximum displacement, drift and base shear for models with the seismic demand of Iraq. Through the analysis of the results, the models proved efficient and stable against the effect of earthquakes, especially when the load applied in the Z long direction, more than the load applied in the X short direction for all models
Effect of Heat Treatments on the Mechanical Properties of Welded Joints of Alloy Steel by Arc Welding
Authors: M. Mahan Hamid
Published: July 2020

This research deals with influence of the heat treatment on welded joints using the shielded metal arc welding (SMAW) on three types of steel with different carbon ratios under constant conditions such as the thickness of metal 20 mm, welding current 120A , voltage 80V, Diameter 15 mm and angle 60 degree. Mechanical tests were carried out to include tensile, bending, micro hardness and microstructure testing. The results showed that the steel with a low carbon content has the highest value of hardness after performing heat treatment in the area of ​​welding line 370 HV. Unlike the moderate carbon- steel, the value of hardness was higher in the 310HV, the tensile strength of steel decreased to 554Mpa when carrying out the heat treatment compared with steel containing higher carbon ratios 523MPa . In the other side  improving toughness and impact strength for welded joints on which heat treatments have been conducted after the welding process , where  highest impact value was obtained in the high carbon steel  214 J
The Role of Global Platforms in Advancing Digital Transformation: Competence and Innovation Aspects
Authors: Danilin I. V. , Mamedyarov Z. A.
Published: July 2020

In the last decade, the foundations of the digital economy have been formed with Internet platforms becoming its largest and most important segment. According to the authors, one of the key problems associated with the development of the digital economy and of Internet platforms is the diffusion of existing and generation of the new competencies. This is important both for platform users and partner companies. The article analyzes the role of platforms in this process and highlights the main channels for competence diffusion. Firstly, individual and, secondly, institutional dimensions of these processes are defined. In the first case, the authors elaborate on the ways of developing user competencies - both basic and specialized. In the second case, the article focuses  on the distribution of organizational and institutional competencies, and best practices among partner companies and participants in corporate ecosystems of platforms. For the partners the primary conditions for acquiring new competencies depend, firstly, on a system of organizational and economic requirements of the platforms. Secondly — on specific digital interfaces. Growth and improvement of services, technology, dynamics and principles of platform market organization provide formation and diffusion of more complex economic and technical competences of digital economy. It is shown that a new powerful source of development and transfer of promising technological and economic competences within the extended platform ecosystems is also being formed. The scope of operations of modern digital platforms, their composition, engagement of all key groups of actors in the innovation processes (including consumers) create unique opportunities for further development of this area.
Particularities of the independent auditor's report on reliability of accounting (financial) statements for 2019: COVID-19 as qualitatively essential information (Part 2)
Authors: Shvyreva O.I. , Kruglyak Z.I. , Petukh A.V.
Published: July 2020

Subject. This article discusses the issues related to the practice of financial reporting in the face of uncertainties caused by the coronavirus contagion, as well as the specifics of the audit strategy and formation of an audit opinion on this reporting.
Objectives. The article aims to identify the quality characteristics of financial reporting prepared in the context of the COVID-19 pandemic and justify the key aspects of assurance engagement completion in an extremely uncertain epidemiological and economic situation.
Methods. For the study, we used an abstract-logical method, content analysis techniques, systematization, and classification.
Results. Analyzing the impact of the extremely uncertain epidemiological and economic situation on financial statements, the article clarifies aspects of disclosure of events after the reporting date and threats to business continuity in the annual reporting of economic entities. The article identifies possible alternative procedures and algorithms to obtain proper evidence when it is insufficient in the face of the inability to meet certain audit standards requirements in a remote audit environment. The article defines the impact of COVID-19 risk disclosure on the structure of the audit report and opinion.
Relevance. The results of the study can be used in the practical activities of economic entities that prepare financial statements in the face of significant uncertainty, as well as auditors and audit organizations.
Assessing the competitiveness of the resort area
Authors: Nefedova K.A. , Maslakova D.O.
Published: July 2020

Subject. This article discusses the issues of development of the Krasnaya Polyana resort area.
Objectives. The article aims to assess the competitive ability and attractiveness of this resort area through developing indicators.
Methods. For the study, we used a comparative analysis, and factor and ranking score techniques.
Results. The article offers original methods to assess the competitiveness of the ski resort area and describes possible directions to increase and improve the competitiveness and attractiveness of ski resorts.
Conclusions. Comprehensive development indicators help assess the competitive ability of the ski resort area. Modified expert, sociological, rating, and differential methods contribute to the effective management of the resort area's advantages.
Formation and implementation of regional investment projects in the economic space of the macro-region: Some particularities
Authors: Khomenko V.V.
Published: July 2020

Subject. This article discusses the issues related to the implementation of regional investment projects as an effective tool for investment activities.
Objectives. The article aims to develop a comprehensive system for the formation and implementation of investment projects, considering the Sverdlovsk Oblast as a case study.
Methods. For the study, I used the methods of logical, statistical, and business analyses, and comparison.
Results. The article offers an original interpretation of the concepts of Regional Investment and Regional Investment Project and presents a comprehensive system of forming and implementing regional investment projects in the macro-region.
Conclusions. Any investment project can be considered as a platform for attracting investment. It contains resources for a useful economic effect in the future. Regional investment projects are a catalyst for economic growth.
The impact of business tourism clustering on the regional economy's development: A Greater Moscow case study
Authors: Golondarev K.S.
Published: July 2020

Subject. This article explores the issues of business tourism clustering in Greater Moscow.
Objectives. The article intends to justify the need to create a business tourism cluster in Greater Moscow to improve the investment climate in the region.
Methods. For the study, I used a multivariate analysis, forecasting, and extrapolation.
Results. The article shows a certain relationship between the efficient functioning of the business tourism cluster and the economy's development.
Conclusions and Relevance. Certain types of tourist clusters can serve as platforms for attracting investors and implementing marketing plans. The business tourism cluster is a link between buyers and sellers in various industries. The results of the study can be used to improve the effectiveness of the cluster initiative in business tourism, as well as find ways of cooperation between the State and private investors when creating the business tourism cluster in Greater Moscow.
Effect of salinity on oil production: review on low salinity waterflooding mechanisms and exploratory study on pipeline scaling
Authors: Zhang Tao , Li Yiteng , Li Chenguang , Sun Shuyu
Published: July 2020

The past decades have witnessed a rapid development of enhanced oil recovery techniques, among which the effect of salinity has become a very attractive topic due to its significant advantages on environmental protection and economical benefits. Numerous studies have been reported focusing on analysis of the mechanisms behind low salinity waterflooding in order to better design the injected salinity under various working conditions and reservoir properties. However, the effect of injection salinity on pipeline scaling has not been widely studied, but this mechanism is important to gathering, transportation and storage for petroleum industry. In this paper, an exhaustive literature review is conducted to summarize several well-recognized and widely accepted mechanisms, including fine migration, wettability alteration, double layer expansion, and multicomponent ion exchange. These mechanisms can be correlated with each other, and certain combined effects may be defined as other mechanisms. In order to mathematically model and numerically describe the fluid behaviors in injection pipelines considering injection salinity, an exploratory phase-field model is presented to simulate the multiphase flow in injection pipeline where scale formation may take place. The effect of injection salinity is represented by the scaling tendency to describe the possibility of scale formation when the scaling species are attached to the scaled structure. It can be easily referred from the simulation result that flow and scaling conditions are significantly affected if a salinity-dependent scaling tendency is considered. Thus, this mechanism should be taken into account in the design of injection process if a sustainable exploitation technique is applied by using purified production water as injection fluid. Finally, remarks and suggestions are provided based on our extensive review and preliminary investigation, to help inspire the future discussions.
Adverse Events in Coronavirus Disease Patients Management: A Pictorial Essay
Authors: Angileri Salvatore Alessio , Petrillo Mario , Meglio Letizia Di , Arrichiello Antonio , Rodà Giovanni Maria , Ierardi Anna Maria , Uberoi Raman , Carrafiello Gianpaolo
Published: July 2020

Clinical manifestation of coronavirus disease (COVID-19) varies from asymptomatic to severe clinical forms that can result in acute respiratory distress syndrome or in multiple organ dysfunction syndromes. There are no guidelines, based on randomized controlled trials, for the treatment of COVID-19 patients. The treatment is based on antiviral drugs, invasive and non-invasive ventilation supports, and anticoagulant therapy. This is a pictorial essay covering the multiple adverse events encountered during the treatment of COVID-19 patients in an area with a high pandemic incidence. Adverse events are defined as unexpected events following treatment for the infection. The cases described would be useful in aiding early diagnosis, limiting and improving the management of serious complications for patients, and allowing rapid and appropriate treatment.
A Steady-State Algebraic Model for the Time Course of Covalent Enzyme Inhibition
Authors: Kuzmic Petr
Published: July 2020

This report describes an algebraic equation for the time course of irreversible enzyme inhibition following a two-step mechanism. In the first step, the enzyme and the inhibitor associate reversibly to form a non-covalent complex. In the second step, the noncovalent complex is irreversibly converted to the final covalent conjugate. Importantly, the algebraic derivation was performed under the steady-state approximation. Under the previously invoked rapid-equilibrium approximation [Kitz & Wilson (1962) J. Biol. Chem. 237, 3245] it is by definition assumed that the rate constant for the reversible dissociation of the initial noncovalent complex is very much faster than the rate constant for the irreversible inactivation step. In contrast, the steady-state algebraic equation reported here removes any restrictions on the relative magnitude of microscopic rate constants. The resulting formula was used in heuristic simulations designed to test the performance of the standard rapid-equilibrium kinetic model. The results show that if the inactivation rate constant is significantly higher than the dissociation rate constant, the conventional “kobs” method for evaluating the potency of covalent inhibitors in drug discovery is incapable of correctly distinguishing between the two-step inhibition mechanism and a simpler one-step variant, even for inhibitors that have very high binding affinity in the reversible noncovalent step.
Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
Authors: Dorst Andrea , Shchelik Inga S. , Schäfle Daniel , Sander Peter , Gademann Karl
Published: July 2020

Fidaxomicin (1, tiacumicin B, lipiarmycin A3) is a marketed antibiotic that is used in the treatment of C. difficile infections. Based on the analysis of a cryo- EM structure of fidaxomicin binding to its target enzyme (RNA-polymerase), a cation-p interaction of the aromatic moiety with an arginine residue was identified. Therefore, the variation of the substituents and concurrently changing the electronic properties of the aryl moiety represents an interesting strategy in search for new fidaxomicin analogs. Herein, we report the first semisynthetic access to new fidaxomicin analogs with varying halogen substituents via a Pd-catalyzed hydrodechlorination reaction. Subsequent iodination gave access to the first iodo-fidaxomicin derivatives, which matched or improved antibacterial properties compared to fidaxomicin against Mycobacterium tuberculosis and Staphylococcus aureus ATCC 29213.
Robotic Catalysis: A High-Throughput Method for Miniature Screening of Mesoporous Metal Oxides
Authors: Potgieter Kariska , Aimon Anthony , Smit Elize , Delft Frank von , Meijboom Reinout
Published: July 2020

A high-throughput method for the screening of miniature mesoporous metal oxide oxidation catalysts were developed. This was achieved by using multiple robotic techniques including 3D printing. The catalysts (Co3O4, Au/Co3O4, Pd/Co3O4 and Co/Mn mesoporous metal oxides) were screened for their activity towards the oxidation of morin.
Forcing or Forced Exertions in Amalgamation of Nanoparticles and Particles inside the Solution
Authors: Ali Mubarak , Lin I-Nan
Published: July 2020

The study of forcing or forced exertions in amalgamating or amalgamated nanoparticles and particles inside the solution is important for the scientific societies in the fields of physical, chemical and mathematical sciences. Observing live dynamics of nanoparticles and particles inside the solution is a challenging task. Again, it is not an appropriate way to discuss amalgamating nanoparticles and particles based only on visualized dynamics. However, suitably captured microscopic images can identify different modes of forcing or forced exertions in amalgamated nanoparticles and particles. Nanoparticles and particles when just at resting positions amalgamate under resultant differences of exerting forces, which are not only related to poles of occupied quadrants, but also related to their own drawn poles. So, colloidal nanoparticles and particles amalgamate from sides experiencing a greater exertion of force. In amalgamation of nanoparticles and particles, the exerted force successively remains in mute, alert and functioning mode. Contrarily, the energy behavior successively remains in functioning, alert and mute mode. Amalgamation of nanoparticles and particles depends on their features and conceived focusing lengths. This is through the resultant differences of exerting forces for two frame of references. Particles of geometrical shapes largely experience the even exertion of forces in their amalgamation, which is not the case for distorted particles. Nanoparticles and particles inside the solution are the best candidates to track nature of exerting forces, and so is the case with energy behaviors, too.
The analysis of NQO1 isoforms as an Off-target to anti-cancer drug RH1 using molecular modeling and structure-based drug discovery approaches
Authors: Pramodkumar P Gupta  , Shanker L Kothari  , Mindaugas Valius  , Jonas Cicenas  , Virupaksha A Bastikar
Published: July 2020

NQO1 is already evaluated for its high-level expression in numerous human cancers as compared with normal tissues. RH1 acts as an indigenous prodrug to NQO1. In our preceding work Off-targeting of (RH1) drug to protein kinases is well reported. Numerous protein isoforms have reported a potential drug target and biomarkers in cancer and related diseases. In the present study, the 3D structure of all the three NQO1 isoforms is modelled using the homologybased concept, evaluated for their conformational stability and energy forms by MD simulation. MSA and related method used for binding site prediction. Protein-ligand interactions were studied using molecular docking approach. The 3D modelled structure of NQO1 isoform 2 and 3 exhibited a conformational change in the protein FAD and RH1 binding region due to the absence of a few key amino acids. Docking results revealed a good degree of binding energy and interaction between the selected NQO1 isoforms, FAD and RH1. As FAD acts as a floor surface to RH1, a similar trend observed in the NQO1 isoform 2 and 3. Hence the NQO1 isoforms 2 and 3 could be a drug target to anticancer prodrug RH1 and can be further investigated in the lab.
Pulmonary drug delivery-Determining attributes
Authors: Hafsa P V  , Vidya Viswanad
Published: July 2020

Pulmonary diseases are one of the significant conditions and influence the lifestyle for a majority of the population in today’s world. From ancient times, inhalational drug delivery is being utilised to target the lungs for the management and treatment of pulmonary diseases with reduced side effects. Factors like the physiology of the respiratory system, selection of devices, particle characteristics, and formulation characteristics affect the efficiency of inhalational drug delivery. The precise usage of the inhaler device is indispensable for the efficient delivery of drugs. The characteristic particle impacts the region of drug deposition and in turn influences drug dissolution. Drug dissolution is also affected by the physiological aspect of the respiratory tract, which is concerned primarily in disease states. Formulation type and characteristics decide the release mechanism and influences the inhalational pattern. Liposomes, nanoparticles, microparticles, micelles, dendrimers, etc. can be utilised for passive and active targeting of drugs to the lungs. Inhalational drug delivery can be harnessed to deliver therapeutic agents to systemic circulation for diseases apart from pulmonary diseases. The inhalational drug delivery techniques and devices are being continuously researched upon and reworked to acquire better drug loading with minor loss during drug delivery. The review focuses on the significance and factors associated with pulmonary drug delivery.
Addressed Blame and Hostility
Authors: De Mesel Benjamin
Published: July 2020

Bagley (2017) sets out a dilemma for addressed blame, that is, blame addressed to its targets as an implicit demand for recognition. The dilemma arises when we ask whether offenders would actually appreciate this demand, via a sound deliberative route from their existing motivations. If they would, their offense reflects a deliberative mistake. If they wouldn't, addressing them is futile, and blame's emotional engagement seems unwarranted. Bagley wants to resolve the dilemma in such a way that addressed blame's distinctive elements of hostility and emotional engagement can be accounted for. I argue that Bagley's focus on the proleptic character of addressed blame helps to avoid the dilemma, but that Bagley has difficulties accounting for the element of hostility in addressed blame. I suggest that an alternative account of addressed blame (1) makes better sense of Bagley's paradigm example, (2) avoids Bagley's dilemma in the way Bagley's original solution does, because it preserves addressed blame's proleptic character, and (3) can account for addressed blame's elements of emotional engagement and hostility. .
Creases and boundary conditions for subdivision curves
Authors: Kosinka J , Sabin M , Dodgson Neil
Published: July 2020

Our goal is to find subdivision rules at creases in arbitrary degree subdivision for piece-wise polynomial curves, but without introducing new control points e.g. by knot insertion. Crease rules are well understood for low degree (cubic and lower) curves. We compare three main approaches: knot insertion, ghost points, and modifying subdivision rules. While knot insertion and ghost points work for arbitrary degrees for B-splines, these methods introduce unnecessary (ghost) control points. The situation is not so simple in modifying subdivision rules. Based on subdivision and subspace selection matrices, a novel approach to finding boundary and sharp subdivision rules that generalises to any degree is presented. Our approach leads to new higher-degree polynomial subdivision schemes with crease control without introducing new control points. © 2014 The Authors. Published by Elsevier Inc.
Mathematical characterization of Bridget Riley's stripe paintings
Authors: Dodgson Neil
Published: July 2020

I investigate whether mathematical measures can characterize Bridget Riley's stripe paintings. This is motivated by three considerations: (1) stripe paintings are an incredibly constrained art form, therefore it should be relatively straightforward to ascertain whether or not there is a mathematical characterization; (2) Bridget Riley's approach to composition is methodical and thoughtful, so we can assume that her paintings are carefully constructed rather than random and (3) Riley's paintings can appear random on a first glance but have an underlying structure, therefore Riley's works are challenging to characterize because they are close to random while not actually being so. I investigate entropy (both global and local), separation distance and auto-correlation. I find that all can provide some characterization, that entropy provides the best judge between Riley's work and randomly generated variants, and that the entropy measures correlate well with the art-critical descriptions of Riley's development of this style over the five years in which she worked with it. © 2012 Taylor & Francis.
Abstract depiction of human and animal figures
Authors: Dodgson Neil
Published: July 2020

© 2018 Copyright held by the owner/author(s). Publication rights licensed to the Association for Computing Machinery. The human figure is important in art. I discuss examples of the abstract depiction of the human figure and the challenge faced in algorithmically mimicking what human artists can achieve. The challenge lies in the human brain having enormous knowledge about the world and an ability to make fine distinctions about other humans from posture, clothing and expression. This allows a human to make assumptions about human figures from a tiny amount of data, and allows a human artist to take advantage of this when creating art. We look at examples from impressionist painting, cross-stitch, knitting, pixelated renderings in early video games, and the stylisation used by the artists of children’s books.
Community Empowerment through Freshwater Fish Processing (Toman) as a Result of Processed Creative Communities in Kumba Village, Jagoi Babang District, Bengkayang Regency
Authors: Sulistri Emi , Yanti Lili , Mulyani Sri , Nurhayati Nurhayati , Sumarli Sumarli , Susanto Heru , Setyowati Rini , Wahyuni Rika , Utama Erdi Guna
Published: July 2020

Training and mentoring are conducted for Kumba hamlet residents, especially among housewives in Jagoi Babang District. This mentoring program involves the lecturers and students of KKN STKIP Singkawang. A method that is used is the identification of the programs is socialization, training, and mentoring directly resulted in the form of the manufacturing practice of toman fish Abon. Toman fish processing into Abon is one way to utilize the potential of toman fish as a skills program to maximize innovative, creative and economic empowered business opportunities. The results of this socialization activity are students can play an active role in the activities and participants involved in Kumba Village can be understood the material presented. Overall, community empowerment partners can understand and practice material related to how they are created, the benefits, and marketing management. However, more intensive assistance is needed for business management related to business planning and financial management.
Socialization Of Prevention Of Sexual Harassment Through Toilet Training In The Village Of Jagoi
Authors: Zulfahita Zulfahita , Utami Citra , Fitri Fitri , Wulandari Fajar , Istirahayu Iip
Published: July 2020

Sexual harassment is still a taboo subject. This causes many victims of sexual harassment who do not dare to report to others or to the authorities. The number of cases of sexual harassment that occurred, both in the neighborhood and at school, it is important to give a good understanding of sexual harassment and how to avoid it. In response to this, the community service team needs to provide counseling about violence that occurs to children, how to communicate well with children, how to learn language in children, and the importance of conveying reproductive health to children properly. So that this socialization activity has a major role to prevent and provide knowledge and understanding of toilet training, personal areas, and sexual violence so as to prevent sexual harassment. The method used is socialization and documentation, this socialization activity was carried out on Friday, 18 January 2019 and took place in the village of Jagoi Babang. A facilitator must be very careful in the process of socialization, given the very heterogeneous conditions of the community, both the level of education, character, acceptance and understanding of the community. Socialization that is carried out to prevent sexual abuse especially in the area of private organs (sensitive areas) of the body is an important thing that should have been introduced to children from an early age. This is the duty of parents to be able to convey this information in good language and easily understood by children, because of the rampant incidence of sexual abuse, especially in children, whether boys or girls.
Analysis of the effectiveness of electric and gas boilers in agricultural buildings
Authors: Chulenyov Anatoly  Sergeevich , Detkin Vladimir Dmitrievich , Paramonov Nikita Igorevich
Published: July 2020

The article considers and analyzes the efficiency of gas and electric boilers in agricultural buildings. The economic calculation of the efficiency of the use of electric boilers is carried out. It is proposed a method for the most efficient use of electric boilers in agricultural buildings.
Variability and interconnection of economically useful indicators of soybeans under the influence of herbicides
Authors: Lobachev Yuriy Viktorovich , Krasilnikov Valeriy Tikonovich
Published: July 2020

Under the conditions of the Right Bank of the Saratov Region, the effect of four herbicides, two new tank mixtures and two new compositions of herbicides on the value and variability of the following indicators of soybeans: “grain yield”, “number of beans from a plant”, “the number of grains per plant", "the mass of 1000 grains", "the protein content in the grain” was studied in three field experiments using two-way   variance and correlation analysis. The relationships between grain yield and elements of its structure, grain yield and protein content in grain are studied. All studied variants after application of herbicides significantly exceeded the control variant in grain yield. Options with the use of a new tank mixture of frontier optima + gezagard herbicides, frontier optima + galaxy top herbicidal compositions, hezagard + galaxy top herbicide compositions significantly exceeded the grain yield after application of  herbicides. This led to a decrease in the variability of the studied indicators and changed the nature of the correlation dependence of grain productivity with other economically useful indicators of soybeans. The specific effect of the application of individual herbicides, their tank mixtures and compositions on the variability and interconnection of economically useful indicators of soybeans has been established.
The effect of dietary supplements on the growth, development and prevention of diseases of hypotrophic piglets
Authors: Polozuk Olga Nikolaevna , Zabelina Margarita Vasilyevna
Published: July 2020

It was established that the use of a probiotic based on bacteria of the genus Bacillus of the B. subtillus and B. amyloliquefaciens bacillus strains in hypotrophic piglets in the early postnatal period of development made it possible to take top dressing earlier than the peers of the control group, to actively respond to external stimuli, and the mother’s call during feeding. At the end of the experiment, the safety of hypotrophic piglets in the experimental group was 8.2% higher than that of the control analogues. The difference in body weight gain between physiologically developed young growth and hypotrophic piglets in the control and experimental groups was maintained throughout the experiment, at the end of the experiment it was higher by 12.7 and 11.1%, respectively.
Reduction the impact of running system of sprinkling machine on the soil
Authors: Zhuravleva Larisa  Anatolievna
Published: July 2020

Carried out researches have allowed to establish the optimum plan for the installation of sprinklers for sprinkling machine "Kuban-LK1M" (Cascade) and "CASCADE" in accordance with the applicable running systems and parameters of water conveyance pipeline, load-bearing capacity of the soil and the application rate.
Od gramatike do komunikacije i natrag
Authors: Martinović Blaženka
Published: July 2020

Normativni priručnici najmanje su odmicali od tzv. klasičnog naglašavanja upravo na primjeru zanaglasnih dužina. Pomake čine tek suvremene gramatike u kojima se razdvaja „gramatika“ od „komunikacije“, čime se naznačuje da je status dužine u komunikaciji (dakle u uporabi, uzusu) drukčiji. Budući da je dužina, između ostalog, vezana uz određene sufikse i gramatičke morfeme, a s druge strane krajnje dužine prve se reduciraju u govoru, raskorak uzusa i propisane norme čini se i većim. Komparativnom analizom priručnika utvrđuje se jesu li učinjeni pomaci u smjeru komunikacije. Analizom uzusa (govornika visinskog i udarnog sustava) ukazuje se na mjesta na kojima je dužina (ne)stabilnija te se pojašnjava zašto se dužina reducira ili nestaje, kada se pozornost preusmjeri s gramatike na komunikaciju.
Sustratos alternativos para la producción de plántulas de tomate de cáscara (Physalis ixocarpa Brot.) en Chiapas
Authors: Caballero Salinas Juan Carlos , Ovando-Salinas Sindy Guadalupe , Núñez-Ramos Erasmo , Aguilar-Cruz Fabián
Published: July 2020

El presente trabajo tuvo como objetivo evaluar el efecto de distintos sustratos alternativos en la emergencia y crecimiento de Physalis ixocarpa Brot. obtenidos en cepellón, bajo condiciones de malla sombra. La investigación se llevó a cabo en el municipio de Cintalapa, Chiapas. Los sustratos empleados fueron T1 cosmopeat usado como testigo, T2 humus de lombriz, T3 aserrín de Pinus oocarpa y T4 composta. Los tratamientos se establecieron bajo un diseño completamente al azar con cuatro repeticiones, sembrándose 50 semillas por cada repetición en bandejas de unicel. Las variables de estudio fueron sometidas a un análisis de comparación de medias (