bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining Rural and Racial Disparities in the Relationship Between Loneliness and Social Technology Use Among Older Adults
Authors: Byrne Kaileigh A. , Anaraky Reza Ghaiumy , Dye Cheryl , Ross Lesley A. , Chalil Madathil Kapil , Knijnenburg Bart , Levkoff Sue
Published: September 2021

Loneliness, the subjective negative experience derived from a lack of meaningful companionship, is associated with heightened vulnerability to adverse health outcomes among older adults. Social technology affords an opportunity to cultivate social connectedness and mitigate loneliness. However, research examining potential inequalities in loneliness is limited. This study investigates racial and rural-urban differences in the relationship between social technology use and loneliness in adults aged 50 and older using data from the 2016 wave of the Health and Retirement Study (N = 4,315). Social technology use was operationalized as the self-reported frequency of communication through Skype, Facebook, or other social media with family and friends. Loneliness was assessed using the UCLA Loneliness scale, and rural-urban differences were based on Beale rural-urban continuum codes. Examinations of race focused on differences between Black/African-American and White/Caucasian groups. A path model analysis was performed to assess whether race and rurality moderated the relationship between social technology use and loneliness, adjusting for living arrangements, age, general computer usage. Social engagement and frequency of social contact with family and friends were included as mediators. The primary study results demonstrated that the association between social technology use and loneliness differed by rurality, but not race. Rural older adults who use social technology less frequently experience greater loneliness than urban older adults. This relationship between social technology and loneliness was mediated by social engagement and frequency of social contact. Furthermore, racial and rural-urban differences in social technology use demonstrated that social technology use is less prevalent among rural older adults than urban and suburban-dwelling older adults; no such racial differences were observed. However, Black older adults report greater levels of perceived social negativity in their relationships compared to White older adults. Interventions seeking to address loneliness using social technology should consider rural and racial disparities.
Food Safety Knowledge, Attitudes, and Practices Among Jordan Universities Students During the COVID-19 Pandemic
Authors: Osaili Tareq M. , Al-Nabulsi Anas A. , Taybeh Asma' O.
Published: September 2021

Objective: This study aimed to evaluate food safety knowledge, attitudes and practices (KAP) amongst university students in Jordan and changes in food-related behaviors during the COVID-19 pandemic. Correlation between food safety KAP scores and general characteristics of university students was also evaluated.

Methods: A cross-sectional study was conducted where an Internet-based questionnaire was distributed through social media platforms. The sample consisted of 1,739 respondents from 29 Jordanian universities. The participants completed a 58-item questionnaire covering demographical characteristics and different food safety aspects which were namely “COVID-19 food-related attributes,” “food cooking and storage,” “personal hygiene.” “cross-contamination prevention/disinfection procedures.” and “restaurant hygiene.” Descriptive statistics, Chi square tests and binary logistic analysis were used to assess the data.

Results: The sample consisted of 67.2% females with a mean age of 21.3 ± 1.8 years. The average overall score of the tested aspects was 14.1/34.0 which corresponds to 41.3% of the questions being answered correctly. The percentage of correct answers of “COVID-19 food-related attributes,” “food cooking and storage,” “cross-contamination prevention/disinfection procedures,” “personal hygiene” and “restaurant hygiene” was 56.8, 36.6, 28.4, 44.6. and 36.9%, respectively. A significant (P <0.05) association between respondents' food safety KAP scores and gender, marital status, university degree, employment status, self-rating of food safety knowledge, and the source of food safety information.

Conclusion: University students in Jordan had insufficient KAP scores which is a concerning trend during the pandemic. Teaching fundamentals of food safety in the form of short courses/ lectures is recommended.
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
Authors: Fernandes Stephanie A. , Demetriades Constantinos
Published: September 2021

The mechanistic Target of Rapamycin (mTOR) is a growth-related kinase that, in the context of the mTOR complex 1 (mTORC1), touches upon most fundamental cellular processes. Consequently, its activity is a critical determinant for cellular and organismal physiology, while its dysregulation is commonly linked to human aging and age-related disease. Presumably the most important stimulus that regulates mTORC1 activity is nutrient sufficiency, whereby amino acids play a predominant role. In fact, mTORC1 functions as a molecular sensor for amino acids, linking the cellular demand to the nutritional supply. Notably, dietary restriction (DR), a nutritional regimen that has been shown to extend lifespan and improve healthspan in a broad spectrum of organisms, works via limiting nutrient uptake and changes in mTORC1 activity. Furthermore, pharmacological inhibition of mTORC1, using rapamycin or its analogs (rapalogs), can mimic the pro-longevity effects of DR. Conversely, nutritional amino acid overload has been tightly linked to aging and diseases, such as cancer, type 2 diabetes and obesity. Similar effects can also be recapitulated by mutations in upstream mTORC1 regulators, thus establishing a tight connection between mTORC1 signaling and aging. Although the role of growth factor signaling upstream of mTORC1 in aging has been investigated extensively, the involvement of signaling components participating in the nutrient sensing branch is less well understood. In this review, we provide a comprehensive overview of the molecular and cellular mechanisms that signal nutrient availability to mTORC1, and summarize the role that nutrients, nutrient sensors, and other components of the nutrient sensing machinery play in cellular and organismal aging.
Analog Radio Over Fiber Aided C-RAN: Optical Aided Beamforming for Multi-User Adaptive MIMO Design
Authors: Li Yichuan , Ghafoor Salman , Butt Muhammad Fasih Uddin , El-Hajjar Mohammed
Published: September 2021

Given the increasing demand for high data-rate, high-performance wireless communications services, the demand on the radio access networks (RAN) has been increasing significantly, where optical fiber has been widely used both for the backhaul and fronthaul. Additionally, advances in signal processing such as multiple-input multiple-output (MIMO) techniques, have improved the performance as well as transmission rate of communications networks. Beamforming has been used as an efficient MIMO technique for providing a signal to noise ratio (SNR) gain as well as reducing the multi-user interference. However, beamforming requires the employment of phase-shifters, which suffers from reduced phase resolutions, degraded noise figures as well as beam-squinting in addition to the implementation challenges. Hence, in this paper we employ an analogue radio over fiber (A-RoF) aided architecture for supporting the requirements of the current and future mobile networks, where we design a photonics aided beamforming technique in order to eliminate the bulky electronic phase-shifters and the beam-squinting effect, while also providing a low-cost RAN solution. Additionally, this photonics aided beamforming is combined with a reconfigurable multi-user MIMO technique, where users can communicate with one or multiple remote radio heads (RRHs), while employing stand-alone beamforming, beamforming combined with diversity or with multiplexing depending on the available resources and the user channel information as well as the quality of service requirements.
Surgical Approaches to Upper Limb Spasticity in Adult Patients: A Literature Review
Authors: Hashemi Mahdis , Sturbois-Nachef Nadine , Keenan Marry Ann , Winston Paul
Published: September 2021

Introduction:Spasticity is the main complication of many upper motor neuron disorders. Many studies describe neuro-orthopedic surgeries for the correction of joint and limb deformities due to spasticity, though less in the upper extremity. The bulk of care provided to patients with spasticity is provided by rehabilitation clinicians, however, few of the surgical outcomes have been summarized or appraised in the rehabilitation literature.

Objective:To review the literature for neuro-orthopedic surgical techniques in the upper limb and evaluate the level of evidence for their efficacy in adult patients with spasticity.

Method:Electronic databases of MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews were searched for English, French as well as Farsi languages human studies from 1980 to July 2, 2020. After removing duplicated articles, 2,855 studies were screened and 80 were found to be included based on the criteria. The studies were then divided into two groups, with 40 in each trial and non-trial. The results of the 40 trial articles were summarized in three groups: shoulder, elbow and forearm, and wrist and finger, and each group was subdivided based on the types of intervention.

Results:The level of evidence was evaluated by Sackett's approach. There were no randomized control trial studies found. About, 4 studies for shoulder, 8 studies for elbow and forearm, 26 studies for wrist and finger (including 4 for the thumb in palm deformity), and 2 systematic reviews were found. Around, two out of 40 trial articles were published in the rehabilitation journals, one systematic review in Cochrane, and the remaining 38 were published in the surgical journals.

Conclusion:Most surgical procedures are complex, consisting of several techniques based on the problems and goals of the patient. This complexity interferes with the evaluation of every single procedure. Heterogenicity of the participants and the absence of clinical trial studies are other factors of not having a single conclusion. This review reveals that almost all the studies suggested good results after the surgery in carefully selected cases with goals of reducing spasticity and improvement in function, pain, hygiene, and appearance. A more unified approach and criteria are needed to facilitate a collaborative, evidence-based, patient referral, and surgical selection pathway.
A Mixed Methods Study of Functioning and Rehabilitation Needs Following COVID-19
Authors: Backmann Tina , Maribo Thomas , Zwisler Ann-Dorthe , Davidsen Jesper Rømhild , Rottmann Nina
Published: September 2021

COVID-19 can lead to a long-term loss of functioning, which may affect activities and participation in daily living in various ways. The extent and characteristics of post-COVID-19 persistent symptoms are currently being studied extensively worldwide. The purpose of this exploratory study is to explore functioning and rehabilitation needs among persons with self-reported disability following COVID-19. This mixed methods study is based on data from patient-reported outcome measures (PRO), tests of body functions, visual drawings and focus groups among persons with self-reported disability after having suffered from COVID-19. PRO covered quality of life, activity and participation. Tests of body functions targeted strength and endurance. Focus groups and visual drawings elaborated on how post COVID-19 persistent symptoms affected functioning, activities and daily living. Data was collected in August and September 2020. The study sample consisted of 11 women, nine men, aged 35–79 years. Self-reported PRO data showed low quality of life and disability among the participants primarily related to fatigue, energy and drive, breathing and concentration. Tests of body functions showed low strength in lower extremities but otherwise no striking limitations on a group level. Analysis of the focus groups generated the following four themes: (1) Persistent symptoms, particularly in regards to concentration, memory, lack of energy, fatigue and headaches. (2) Balancing activities in daily living with fluctuating symptoms. (3) Uncertainty and Powerlessness, which included a need for directional guidance in order to regain functioning and unmet needs regarding further clinical assessment of persistent symptoms, referral to rehabilitation and returning to work. (4) Hope associated with the experiences of recovery - and for the future. This study highlights that persons with persistent symptoms after COVID-19 may experience a range of limitations in their daily living. This points toward a need for individual assessment and guidance to tailor relevant rehabilitation.
A Critical Framework to Develop Human-Centric Positive Energy Districts: Towards Justice, Inclusion, and Well-Being
Authors: Nguyen Minh-Thu , Batel Susana
Published: September 2021

Positive Energy Districts (PEDs) are a new energy initiative from European member states. They are, simply put, local districts which produce more energy than they consume. PEDs are expected to adopt a more human-centric perspective in order to create more liveable and sustainable urban neighbourhoods. However, as previous research on energy transitions has demonstrated, the mainstream approach and technocratic tradition of research and policy vis-à-vis energy transitions could result in the perpetuation of social inequalities, energy injustices, and the passive participation of citizens also within PEDs. Hence, it is crucial in these early days of PEDs to discuss what a human-centric approach should entail and how it should be enacted. Based on a narrative literature review of critical social sciences' energy research (and specifically from social and environmental psychology), this paper will propose a critical framework containing five key dimensions which are relevant for creating more just and inclusive PEDs. These are: uncertainty, risk perception and trust; distributive justice; recognition justice and people-place relations; procedural justice; and, routines, capabilities and lived experiences. To that end, it will also discuss the different implications of mainstream and critical approaches in energy research and social sciences in relation to the deployment of human-centric PEDs. The review concludes that in order to successfully deploy human-centric PEDs, a critical approach is needed and presents some concrete recommendations for future research and policy in order to adopt such an approach. These include: considering justice, inclusion and the well-being of affected socio-ecological systems in the whole-life cycle of PEDs; better integration of indigenous capabilities; and, an ethos of de-growth and circularity in their deployment.
Two-Dimensional Structure of Flow Channels and Associated Upward Field-Aligned Currents: Model and Observations
Authors: Lyons Larry. R. , Nishimura Yukitoshi , Wang Chih-Ping , Liu Jiang , Bristow William. A.
Published: September 2021

Flow bursts are a major component of transport within the plasma sheet and auroral oval (where they are referred to as flow channels), and lead to a variety of geomagnetic disturbances as they approach the inner plasma sheet (equatorward portion of the auroral oval). However, their two-dimensional structure as they approach the inner plasma sheet has received only limited attention. We have examined this structure using both the Rice Convection Model (RCM) and ground-based radar and all sky imager observations. As a result of the energy dependent magnetic drift, the low entropy plasma of a flow burst spreads azimuthally within the inner plasma sheet yielding specific predictions of subauroral polarization stream (SAPS) and dawnside auroral polarization stream (DAPS) enhancements that are related to the field-aligned currents associated with the flow channel. Flow channels approximately centered between the dawn and dusk large-scale convection cells are predicted to give significant enhancements of both SAPS and DAPS, whereas flow channel further toward the dusk (dawn) convection cell show a far more significant enhancement of SAPS (DAPS) than for DAPS (SAPS). We present observations for cases having good coverage of flow channels as they approach the equatorward portion of the auroral oval and find very good qualitative agreement with the above RCM predictions, including the predicted differences with respect to flow burst location. Despite there being an infinite variety of flow channels’ plasma parameters and of background plasma sheet and auroral oval conditions, the observations show the general trends predicted by the RCM simulations with the idealized parameters. This supports that RCM predictions of the azimuthal spread of a low-entropy plasma sheet plasma and its associated FAC and flow responses give a realistic physical description of the structure of plasma sheet flow bursts (auroral oval flow channels) as they reach the inner plasma sheet (near the equatorward edge of the auroral oval).
The Minimum Effective Training Dose Required for 1RM Strength in Powerlifters
Authors: Androulakis-Korakakis Patroklos , Michalopoulos Nick , Fisher James P. , Keogh Justin , Loenneke Jeremy P. , Helms Eric , Wolf Milo , Nuckols Greg , Steele James
Published: September 2021

The aim of this multi-experiment paper was to explore the concept of the minimum effective training dose (METD) required to increase 1-repetition-maximum (1RM) strength in powerlifting (PL) athletes. The METD refers to the least amount of training required to elicit meaningful increases in 1RM strength. A series of five studies utilising mixed methods, were conducted using PL athletes & coaches of all levels in an attempt to better understand the METD for 1RM strength. The studies of this multi-experiment paper are: an interview study with elite PL athletes and highly experienced PL coaches (n = 28), an interview and survey study with PL coaches and PL athletes of all levels (n = 137), two training intervention studies with intermediate-advanced PL athletes (n = 25) and a survey study with competitive PL athletes of different levels (n = 57). PL athletes looking to train with a METD approach can do so by performing ~3–6 working sets of 1–5 repetitions each week, with these sets spread across 1–3 sessions per week per powerlift, using loads above 80% 1RM at a Rate of Perceived Exertion (RPE) of 7.5–9.5 for 6–12 weeks and expect to gain strength. PL athletes who wish to further minimize their time spent training can perform autoregulated single repetition sets at an RPE of 9–9.5 though they should expect that strength gains will be less likely to be meaningful. However, the addition of 2–3 back-off sets at ~80% of the single repetitions load, may produce greater gains over 6 weeks while following a 2-3-1 squat-bench press-deadlift weekly training frequency. When utilizing accessory exercises in the context of METD, PL athletes typically utilize 1–3 accessory exercises per powerlift, at an RPE in the range of 7–9 and utilize a repetition range of ~6–10 repetitions.
Effects of Stance Width and Barbell Placement on Kinematics, Kinetics, and Myoelectric Activity in Back Squats
Authors: Larsen Stian , Kristiansen Eirik , Helms Eric , van den Tillaar Roland
Published: September 2021

Barbell placement and stance width both affect lifting performance in the back squat around the sticking region. However, little is known about how these squat conditions separately could affect the lifting performance. Therefore, this study investigated the effects of stance width and barbell placement upon kinematics, kinetics, and myoelectric activity around the sticking region during a three-repetition maximum back squat. Nine men and nine women (body mass: 76.2 ±11.1, age: 24.9 ± 2.6) performed back squats with four different techniques, such as: high-bar narrow stance (HBNS), high-bar wide stance, low-bar narrow stance, and low-bar wide stance where they lifted 99.2 ± 23.6, 92.9 ± 23.6, 102.5 ± 24.7, and 97.1 ± 25.6 kg, respectively. The main findings were that squatting with a low-bar wide stance condition resulted in larger hip contributions to the total moment than the other squat conditions, whereas squatting with an HBNS resulted in greater knee contributions to the total moment together with higher vastus lateralis and less gluteus maximus myoelectric activity. Our findings suggest that training with an HBNS could be beneficial when targeting the knee extensors and plantar flexors, whereas a low-bar wide stance could be beneficial when targeting the hip extensors.
Gender Empowerment in Agriculture Interventions: What Are We Still Missing? Evidence From a Randomized-Controlled Trial Among Coffee Producers in Honduras
Authors: Rubio-Jovel Karla
Published: September 2021

Latin-American coffee production has largely relegated women to specific family labor tasks, such as berry picking or cooking. But recent years have seen an increasing number of interventions to empower women in the agricultural sector, including coffee. As a contribution to the growing literature on women's empowerment in agriculture, this article draws on a randomized-controlled trial (RCT) to evaluate a gender empowerment project among coffee producers in Honduras. Previous RCT evaluations of gender empowerment interventions have focused on average treatment effects and paid less attention to the diversity of responses in the sample. This article evaluates the effect of a project to empower women in Honduras' coffee sector but pays attention to how the intervention interacted with the amount of land owned by women to produce different outcomes. The intervention consisted of 12 workshops offered to families in 10 coffee-producing groups. The baseline and end-line surveys (2016–2018) included a sample of 88 families (41 intervention and 47 control, from 4 to 5 communities respectively). Results showed limited effects of the intervention on women's empowerment for the pooled sample, but it found heterogeneous positive effects for land-owning women. Women who owned land and received the treatment scored fewer points on a deprivation score, had input over more decisions related to the use of household income, and were more satisfied with their leisure time. For quantity of land owned, this article also found positive heterogeneous effects for the same variables, and additionally for confidence speaking in public. Results suggest that projects to empower women might benefit from a more nuanced approach to the heterogeneity within the target population.
Establishment and Verification of a Perioperative Blood Transfusion Model After Posterior Lumbar Interbody Fusion: A Retrospective Study Based on Data From a Local Hospital
Authors: Liu Bo , Pan Junpeng , Zong Hui , Wang Zhijie
Published: September 2021

Objective: We aimed to analyze the related risk factors for blood transfusion and establish a blood transfusion risk model during the per-ioperative period of posterior lumbar interbody fusion (PLIF). It could provide a reference for clinical prevention and reduction of the risk of blood transfusion during the peri-operative period.

Methods: We retrospectively analyzed 4,378 patients who underwent PLIF in our hospital. According to whether they were transfused blood or not, patients were divided into the non-blood transfusion group and the blood transfusion group. We collected variables of each patient, including age, sex, BMI, current medical history, past medical history, surgical indications, surgical information, and preoperative routine blood testing. We randomly divide the whole population into training group and test group according to the ratio of 4:1. We used the multivariate regression analyses get the independent predictors in the training set. The nomogram was established based on these independent predictors. Then, we used the AUC, calibration curve and DCA to evaluate the nomogram. Finally, we verified the performance of the nomogram in the validation set.

Results: Three or more lumbar fusion segments, preoperative low hemoglobin, with hypertension, lower BMI, and elder people were risk factors for blood transfusion. For the training and validation sets, the AUCs of the nomogram were 0.881 (95% CI: 0.865–0.903) and 0.890 (95% CI: 0.773–0.905), respectively. The calibration curve shows that the nomogram is highly consistent with the actual observed results. The DCA shows that the nomogram has good clinical application value. The AUC of the nomogram is significantly larger than the AUCs of independent risk factors in the training and validation set.

Conclusion: Three or more lumbar fusion segments, preoperative low hemoglobin, with hypertension, lower BMI, and elder people are associated with blood transfusion during the peri-operative period. Based on these factors, we established a blood transfusion nomogram and verified that it can be used to assess the risk of blood transfusion after PLIF. It could help clinicians to make clinical decisions and reduce the incidence of peri-operative blood transfusion.
Treatment Outcome of External Auditory Canal Carcinoma: The Utility of Lateral Temporal Bone Resection
Authors: Saijo Kohei , Ueki Yushi , Tanaka Ryoko , Yokoyama Yusuke , Omata Jo , Takahashi Takeshi , Ota Hisayuki , Shodo Ryusuke , Yamazaki Keisuke , Togashi Takafumi , Okabe Ryuichi , Matsuyama Hiroshi , Honda Kohei , Sato Yuichiro , Morita Yuka , Takahashi Kuniyuki , Horii Arata
Published: September 2021

We examined the role of lateral temporal bone resection (LTBR) in the treatment of external ear canal (EAC) carcinoma between 2007 and 2018. The estimated 3-year disease-free survival (DFS) and disease-specific survival (DSS) according to the tumor stage and treatments were investigated in 36 patients with EAC squamous cell carcinoma. T stage classification according to the University of Pittsburgh staging system was as follows: 14 patients in T1, four patients in T2, nine patients in T3, and nine patients in T4. The 3-year DFS rate was 77.4% for T1 tumors, 100% for T2, 44.4% for T3 tumors, and 11.1% for T4 tumors (p < 001). The 3-year DSS rate was 100% for T1/T2 tumors, 87.5% for T3 tumors, and 11.1% for T4 tumors (p < 0.01). T1/T2 patients received mostly LTBR. Among nine T3 tumors, five patients (56%) received LTBR combined with preoperative chemotherapy and/or postoperative radiation (RT). Four of them had negative surgical margin and survived with no evidence of disease. The DFS of T3 patients who underwent concurrent chemoradiotherapy and LTBR was 0 and 80%, respectively (p = 0.048). For T1/T2 tumors, surgery achieved an excellent outcome. For T3 tumors, LTBR achieved negative surgical margin and showed good survival when combined with preoperative chemotherapy and/or postoperative RT. In contrast, the prognosis of T3 patients who could not undergo surgery was as poor as that of T4 patients. Therefore, in addition to subtotal temporal bone resection, LTBR-based treatment strategy may be a treatment option for limited cases of T3 patients.
Self-Mechanical Anal Dilatation: A Simple Trick to Minimize Postoperative Pain and Stenosis Following Hemorrhoidectomy With Radiofrequency
Authors: Eberspacher Chiara , Mascagni Pietro , Zeri Kenneth Paul , Fralleone Lisa , Naldini Gabriele , Mascagni Domenico
Published: September 2021

Aim: Hemorrhoidectomy is still the most effective surgical treatment for hemorrhoidal disease, but it is, however, associated with complications such as pain and stenosis. We proposed to break the “vicious circle” of “pain–sphincteric spasm–stenosis–pain” with the postoperative use of self-mechanical anal dilation.

Methods: We retrospectively analyzed patients with hemorrhoidal disease presenting with a minimum of piles of three quadrants, treated with radiofrequency hemorrhoidectomy between January 2018 and December 2019. All the patients that at 3 weeks presented sphincteric spasms with painful defecation, were considered. Thirty-nine patients performed the cycle of self-mechanical anal dilation (Group A). This group was 1:1 matched with homogeneous patients from our historical cohort of patients (Group B). The primary endpoint was the pain evaluation, secondary endpoints: WCS, overall satisfaction of the patient, anal sphincter spasm, scarring, and the incidence of postoperative stenosis.

Results: In Group A mean VAS was 3.25 after 14 days of application and 1.15 at the end of the application. In Group B mean VAS was persistently higher, with a mean VAS of 5 (p = 0.000002) and 3.38 (p = 0.0000000000009). In Group A we observed an improvement of symptoms at the end, with a good overall satisfaction (Group A 7.4 vs. Group B 5.9; p = 0.0000007) and a better mean WCS (Group A WCS 2.8 vs. Group B WCS 4.18; p = 0.0001). Stenosis was observed in 3/39 patients of Group B (7.7%).

Conclusions: Self-mechanical anal dilation improves the pain in the late postoperative course, minimizing the risk of anal stenosis.
RETRACTED: Open Resection Compared to Mini-Invasive in Colorectal Cancer and Liver Metastases: A Meta-Analysis
Authors: Gong Jie , Gao Fengwei , Xie Qingyun , Zhao Xin , Lei Zehua
Published: September 2021

Background: We performed a meta-analysis to evaluate the outcomes of minimally invasive surgery and open surgery in the simultaneous resection of colorectal cancer and synchronous colorectal liver metastases.

Methods: A systematic literature search up to April 2021 was done and 13 studies included 1,181 subjects with colorectal cancer and synchronous colorectal liver metastases at the start of the study; 425 of them were using minimally invasive surgery and 756 were open surgery. They were reporting relationships between the outcomes of minimally invasive surgery and open surgery in the simultaneous resection of colorectal cancer and synchronous colorectal liver metastases. We calculated the odds ratio (OR) or the mean difference (MD) with 95% CIs to assess the outcomes of minimally invasive surgery and open surgery in the simultaneous resection of colorectal cancer and synchronous colorectal liver metastases using the dichotomous or continuous method with a random or fixed-effect model.

Results: Minimally invasive surgery in subjects with colorectal cancer and synchronous colorectal liver metastases was significantly related to longer operation time (MD, 35.61; 95% CI, 7.36–63.87, p = 0.01), less blood loss (MD, −151.62; 95% CI, −228.84 to −74.40, p < 0.001), less blood transfusion needs (OR, 0.61; 95% CI, 0.42–0.89, p = 0.01), shorter length of hospital stay (MD, −3.26; 95% CI, −3.67 to −2.86, p < 0.001), lower overall complications (OR, 0.59; 95% CI, 0.45–0.79, p < 0.001), higher overall survival (OR, 1.66; 95% CI, 1.21–2.29, p = 0.002), and higher disease-free survival (OR, 1.49; 95% CI, 1.13–1.97, p = 0.005) compared to open surgery.

Conclusions: Minimally invasive surgery in subjects with colorectal cancer and synchronous colorectal liver metastases may have less blood loss, less blood transfusion needs, shorter length of hospital stay, lower overall complications, higher overall survival, and higher disease-free survival with longer operation time compared with the open surgery. Furthers studies are required to validate these findings.
A Canine's Behavior and Cognitive State as It Relates to Immobility and the Success of Physical Rehabilitation in the Non-ambulatory Spinal Cord Patient
Authors: Thomovsky Stephanie A. , Ogata Niwako
Published: September 2021

Physical rehabilitation (PR) is recommended following spinal cord injury to help improve and maintain muscle elasticity, joint mobility, and nerve health. It can also be used to relieve pain and improve cardiopulmonary fitness in an immobile patient. There is evidence, in human medicine, that PR plays a critical role in mental health and the psychological state of the patient. As part of the assessment phase, human physical therapists often identify psychosocial symptoms and barriers at the start of PR that ultimately may affect improvement in human patients suffering from injury and the loss of mobility. Patient psychological state plays an integral role in healing and outcome during treatment and rehabilitation. Specific interventions set to address these symptoms can better outcome. Arguably, one of the most emotionally traumatizing injuries suffered by a canine patient can be immobility secondary to spinal cord injury. Poorly understood is the role the canine cognitive state plays in the success of rehabilitation following spinal cord injury. Should breed, age, sex, physical fitness, personality, previous experiences and history or home lifestyle, affect the PR assessment of these patients? Do these factors affect eventual outcome following PR? The purpose of this manuscript is to explore psychosocial barriers encountered during injury rehabilitation in humans and determine if the similar barriers need to be considered when assessing a canine patient for spinal cord injury rehabilitation.
Welfare of Native Goat Breeds in Serbia—Emphasis on Parasitological Infections
Authors: Nenadović Katarina , Ilić Tamara , Jovanović Nemanja , Bugarski Dejan , Vučinić Marijana
Published: September 2021

Native goat breeds in Serbia has been recognized as an important element of regional agrobiodiversity and play an important role in the safeguarding of cultural and traditional heritage. The aim of this study was to identify the main welfare issues likely to be encountered in extensive goat farming systems with an emphasis on parasitological infections. The study was conducted during the winter season on four small farms of native Balkan and Serbian white goats. For welfare assessment, animal-based indicators from AWIN protocol for goats were used. All fecal samples for parasites were qualitatively and quantitatively examined. The main welfare issues identified were poor hair coat condition (62.79%), dirty and light soiling hindquarters (31.40%), thin body condition score (26.74%), abscesses (19.78%), and udder asymmetry (18.60%). In addition, an important and prevalent welfare problem identified across all farms was parasite infection and weak significant (p< 0.001) correlation between certain parasites (Strongylidae,Monieziaspp.,Buxtonella sulcate, and Protostrongylidae) and welfare indicators such as poor hair coat condition and nasal discharge. The results of this study provided the first overview and valuable insight into the impact of extensive systems on the welfare of native goats in the Balcan region.
Targeting PI3K Pathway in Pancreatic Ductal Adenocarcinoma: Rationale and Progress
Authors: Mehra Siddharth , Deshpande Nilesh , Nagathihalli Nagaraj
Published: September 2021

Pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest solid tumors that remain treatment-refractory and show a dismal prognosis. More than 90% of PDAC tumors harbor mutations in the K-Ras that exert a strong pro-tumorigenic effect by activating several downstream effector pathways, including phosphatidylinositol-3-kinase (PI3K)-Akt. The role of frequently activated PI3K/Akt pathway in promoting PDAC aggressiveness is well established. Therapeutic approaches targeting PI3K and downstream signaling components in different cellular compartments, including tumor, stromal and immune cells, have directly impacted the tumor burden in this cancer type. Our previous work has demonstrated that targeting the PI3K/Akt/mTOR pathway reduced tumor growth and improved survival in the genetic mouse model of PDAC. Here, we discuss the significance of targeting PI3K signaling and the biological impact of PI3K inhibition in modulating the tumor–stromal immune crosstalk within the microenvironment of pancreatic cancer. Furthermore, this review updates on the current challenges involving the therapeutic implications of targeting this pathway in PDAC.
Crosstalk between Environmental Inflammatory Stimuli and Non-Coding RNA in Cancer Occurrence and Development
Authors: Xu Tingting , Xie Mengyan , Jing Xinming , Cui Jiahua , Wu Xi , Shu Yongqian
Published: September 2021

There is a clear relationship between inflammatory response and different stages of tumor development. Common inflammation-related carcinogens include viruses, bacteria, and environmental mutagens, such as air pollutants, toxic metals, and ultraviolet light. The expression pattern of ncRNA changes in a variety of disease conditions, including inflammation and cancer. Non-coding RNAs (ncRNAs) have a causative role in enhancing inflammatory stimulation and evading immune responses, which are particularly important in persistent pathogen infection and inflammation-to-cancer transformation. In this review, we investigated the mechanism of ncRNA expression imbalance in inflammation-related cancers. A better understanding of the function of inflammation-associated ncRNAs may help to reveal the potential of ncRNAs as a new therapeutic strategy.
The Cell Wall Proteome of Craterostigma plantagineum Cell Cultures Habituated to Dichlobenil and Isoxaben
Authors: Guerriero Gea , Achen Charles , Xu Xuan , Planchon Sébastien , Leclercq Céline C. , Sergeant Kjell , Berni Roberto , Hausman Jean-Francois , Renaut Jenny , Legay Sylvain
Published: September 2021

The remarkable desiccation tolerance of the vegetative tissues in the resurrection species Craterostigma plantagineum (Hochst.) is favored by its unique cell wall folding mechanism that allows the ordered and reversible shrinking of the cells without damaging neither the cell wall nor the underlying plasma membrane. The ability to withstand extreme drought is also maintained in abscisic acid pre-treated calli, which can be cultured both on solid and in liquid culture media. Cell wall research has greatly advanced, thanks to the use of inhibitors affecting the biosynthesis of e.g., cellulose, since they allowed the identification of the compensatory mechanisms underlying habituation. Considering the innate cell wall plasticity of C. plantagineum, the goal of this investigation was to understand whether habituation to the cellulose biosynthesis inhibitors dichlobenil and isoxaben entailed or not identical mechanisms as known for non-resurrection species and to decipher the cell wall proteome of habituated cells. The results showed that exposure of C. plantagineum calli/cells triggered abnormal phenotypes, as reported in non-resurrection species. Additionally, the data demonstrated that it was possible to habituate Craterostigma cells to dichlobenil and isoxaben and that gene expression and protein abundance did not follow the same trend. Shotgun and gel-based proteomics revealed a common set of proteins induced upon habituation, but also identified candidates solely induced by habituation to one of the two inhibitors. Finally, it is hypothesized that alterations in auxin levels are responsible for the increased abundance of cell wall-related proteins upon habituation.
Impact of Fracture Topology on the Fluid Flow Behavior of Naturally Fractured Reservoirs
Authors: Alvarez Leidy Laura , Guimarães Leonardo José do Nascimento , Gomes Igor Fernandes , Beserra Leila , Pereira Leonardo Cabral , de Miranda Tiago Siqueira , Maciel Bruno , Barbosa José Antônio
Published: September 2021

Fluid flow modeling of naturally fractured reservoirs remains a challenge because of the complex nature of fracture systems controlled by various chemical and physical phenomena. A discrete fracture network (DFN) model represents an approach to capturing the relationship of fractures in a fracture system. Topology represents the connectivity aspect of the fracture planes, which have a fundamental role in flow simulation in geomaterials involving fractures and the rock matrix. Therefore, one of the most-used methods to treat fractured reservoirs is the double porosity-double permeability model. This approach requires the shape factor calculation, a key parameter used to determine the effects of coupled fracture-matrix fluid flow on the mass transfer between different domains. This paper presents a numerical investigation that aimed to evaluate the impact of fracture topology on the shape factor and equivalent permeability through hydraulic connectivity (f). This study was based on numerical simulations of flow performed in discrete fracture network (DFN) models embedded in finite element meshes (FEM). Modeled cases represent four hypothetical examples of fractured media and three real scenarios extracted from a Brazilian pre-salt carbonate reservoir model. We have compared the results of the numerical simulations with data obtained using Oda’s analytical model and Oda’s correction approach, considering the hydraulic connectivity f. The simulations showed that the equivalent permeability and the shape factor are strongly influenced by the hydraulic connectivity (f) in synthetic scenarios for X and Y-node topological patterns, which showed the higher value for f (0.81) and more expressive values for upscaled permeability (kx-node = 0.1151 and ky-node = 0.1153) and shape factor (25.6 and 14.5), respectively. We have shown that the analytical methods are not efficient for estimating the equivalent permeability of the fractured medium, including when these methods were corrected using topological aspects.
E-Learning as a Factor Optimizing the Amount of Work Time Devoted to Preparing an Exam for Medical Program Students during the COVID-19 Epidemic Situation
Authors: Roszak Magdalena , Sawik Bartosz , Stańdo Jacek , Baum Ewa
Published: September 2021

The COVID-19 pandemic had a huge impact on the learning and teaching processes, particularly in healthcare education and training, because of the principal position of the cutting-edge student–patient interaction. Replacing the traditional form of organization and implementation of knowledge evaluation with its web-based equivalent on an e-learning platform optimizes the whole didactic process not only for the unit carrying it out but, above all, for students. This research is focused on the effectiveness of the application of e-learning for computer-based knowledge evaluation and optimizing exam administration for students of medical sciences. The proposed approach is considered in two categories: from the perspective of the providers of the evaluation process, that is, the teaching unit; and the recipients of the evaluation process, that is, the students.
Foodborne Botulism in Western Romania: Ten Years’ Experience at a Tertiary Infectious Disease Hospital
Authors: Marincu Iosif , Bratosin Felix , Vidican Iulia , Cerbu Bianca , Suciu Oana , Turaiche Mirela , Tirnea Livius , Timircan Madalina
Published: September 2021

Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium Clostridium botulinum, results in a neuroparalytic disorder capable of severe clinical progression that begins in the cranial nerves and progressively descends. Preventing progression to a severe case entails timely diagnosis since curative assets are restricted. Ingesting food containing a preformed toxin (foodborne botulism) is the most typical form. Methods: Medical records were retrospectively analyzed from 2010 to 2020 for all food botulism cases. A seroneutralization test was performed with type A, B and E anti-botulinum sera to establish the kind of toxin involved. Results: Overall, 18 cases of foodborne botulism were admitted to the hospital during this period and confirmed by laboratory analysis. Most of the participants in our study were men (61.1%), and 77.8% of the total lived in rural areas. All the participants showed classic symptoms of botulism, and dysphagia was present in all cases. The trivalent ABE antitoxin was administered by the hospital, and toxin type B was isolated in all patients. The main sources of the toxin were pork, ham and canned pork meat. Conclusions: Stronger efforts are needed to foster community awareness of foodborne botulism, particularly in home-preserved food.
Heavy Metals and Trace Elements in Human Breast Milk from Industrial/Mining and Agricultural Zones of Southeastern Spain
Authors: Motas Miguel , Jiménez Sandra , Oliva José , Cámara Miguel Ángel , Pérez-Cárceles María Dolores
Published: September 2021

Human breast milk is the most complete foodstuff for infants but can also be a potential source of exposure to toxic chemicals. The aim of this study was to assess the levels of metal pollution in the breast milk of women living in agricultural and industrial/mining areas of the Region of Murcia (Spain) that are well known for their cases of environmental pollution. Human milk samples were collected from 50 mothers and inorganic contaminants were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The mean or maximum concentrations of the different inorganic elements analyzed in breast milk, with the exception of manganese, exceeded the maximum limits established by the WHO and could constitute a high risk for pregnant mothers and their children. The breast milk of women living in the industrial/mining zone presented the highest levels of aluminum, zinc, arsenic, lead, mercury and nickel. On the contrary, the highest concentrations of manganese, chromium and iron were determined in the milk of women living in the agricultural zone. These results suggested and confirmed different profiles of environmental contamination of these areas.
Effect of Environmental Noise, Distance and Warning Sound on Pedestrians’ Auditory Detectability of Electric Vehicles
Authors: Hsieh Min-Chih , Chen Hung-Jen , Tong Ming-Le , Yan Cheng-Wu
Published: September 2021

With developments in science and technology, the number of electric vehicles will increase, and they will even replace ICE vehicles. Thus, perceiving the presence of approaching electric vehicles on the road has become an important issue. In this study, the auditory detectability of the electric vehicle warning sound at different volumes, distances, and environmental noise levels was investigated. To this end, the detection rate was recorded in experiments with three environmental noise levels (50, 60, and 70 dBA), two sound pressure levels (SPLs) of the warning sound (46 and 51 dBA), three frequency combinations of the warning sound (5000, 2500, 1250, and 630 Hz for high frequencies; 2500, 1250, 630, and 315 Hz for medium frequencies; and 1250, 630, 315, and 160 Hz for low frequencies), and five distances (2, 4, 6, 8, and 10 m). The main results showed that the detection rate at 51 dBA was significantly higher than that at 46 dBA under a high-frequency warning sound; however, the detection rates were similar under medium- and low-frequency warning sounds. The participants’ rates of detection for warning sounds were less than 20% under all experimental conditions, and a high-frequency warning sound was not affected by environmental noise. With regard to distances, no significant effects were observed between the distances and the detection rate at any of the three frequencies. In addition, auditory thresholds based on high-, medium-, and low-frequency warning sounds were found through logistic regression analysis results. The results of this study can be used as a reference for the future design of warning sounds.