bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct Oral Anticoagulants Compared with Vitamin K Antagonists for Left Ventricular
Thrombus: A Systematic Review and Meta-analysis
Authors: Fang Shu , Zhu Bao-Zhen , Yang Fan , Wang Zhe , Xiang Qian , Gong Yan-Jun
Published: April 2022

Background:

Direct oral anticoagulants (DOACs) are the guideline-recommended therapy for some
hypercoagulable diseases but are used off-label for left ventricular thrombus (LVT) owing to a paucity of evidence.
We performed a meta-analysis to assess the safety and efficacy of DOACs compared with vitamin K antagonists
(VKAs) for LVT treatment.

Methods:

We comprehensively searched PubMed, EMBASE, Cochrane Library, and Web of Science databases
for studies that compared DOACs with VKAs for LVT treatment. Outcome indicators included stroke or systemic
embolism (SSE), thrombus resolution, bleeding, and death. The Newcastle-Ottawa scale was used to
evaluate the quality of included studies. Data were analyzed using Review Manager 5.3, and the meta-analysis
is registered at PROSPERO (CRD 42020211376).

Results:

We included 12 observational studies (n = 2262 patients). SSE was similar for DOACs and VKAs
groups (odds ratio (OR) = 1.01, 95% confidence interval (CI) 0.66-1.54, P = 0.95). For thrombus resolution,
DOACs were not significantly different to VKAs (OR = 1.15, 95% CI 0.54-2.45, P = 0.71). DOACs and VKAs
had a similar bleeding risk (OR = 0.78, 95% CI 0.45-1.35, P = 0.37). DOACs and VKAs groups had a comparable
mortality (OR = 0.91, 95% CI 0.50-1.65, P = 0.76). Subgroup analysis showed that post-acute myocardial
infarction (AMI) patients using DOACs had a lower risk of SSE (OR = 0.24, 95% CI 0.07-0.87, P = 0.03) and
bleeding (OR = 0.38, 95% CI 0.18-0.81, P = 0.01).

Conclusion:

DOACs and VKAs showed no difference in the safety and efficacy of patients with LVT. DOACs
might be superior to VKAs for LVT treatment in post-AMI patients.

Registration No:

A review protocol (number: CRD 42020211376) was registered in the PROSPERO International
prospective register of systematic reviews.
Effects of Long Noncoding RNA AK093407 on the Biological Behavior of
Colon Cancer Cells and the Underlying Mechanism
Authors: Xuerong Zhao , Ao Sun , Jianping Wang , Xin Zheng , Duoduo Tian , Mingjuan Wang , Lijun Xiao , Enhong Zhao , Cui Zheng-Guo
Published: April 2022

Introduction:

The incidence of colorectal cancer is steadily increasing, and the detection
of related molecular targets is critical for its diagnosis and treatment. Long noncoding RNA
(lncRNA) can play a regulatory role before and after genome transcription, and epigenetic regulation
is involved in the process of tumorigenesis and tumor development.

Method:

In this study, qRT-PCR was performed to evaluate the expression of AK093407 in colon
cancer and colon para-carcinoma tissues and HCT-15 and HCT-116 cells. SiRNA was transfected
into HCT-15 and HCT-116 cells to knock down lncRNA-AK093407. Then, MTT assay was used
to test cell proliferation, and flow cytometry was used to test apoptosis and cell cycle. The protein
expression of caspase-3, caspase-8, caspase-9, bax, bcl-2, cyclin-A1, cyclin-B1, cyclin-D1, cyclin-
E1, p21, p27, and p-Stat3 was determined by Western blot.

Results:

The results showed that the expression of AK093407 in human colon cancer tissue was
higher than in para-carcinoma tissue. The amount of AK093407 in HCT-15 and HCT-116 cells was
higher than that in normal colorectal epithelial NM460 cells. When AK093407 was silenced, the proliferation
of HCT-15 and HCT-116 cells decreased, the apoptosis rate increased, the cell cycle was
arrested in the G1/S phase, the expression of caspase-3, caspase-8, caspase-9, bax, cyclin-A1, cyclin-
B1, p21, p27 increased, and the expression of bcl-2, cyclin-D1, cyclin-E1, p-Stat3 decreased.

Conclusion:

These results showed that knockdown of AK093407 could inhibit colon cancer cell
proliferation, induce apoptosis and cell cycle arrest, influence the expression of vital factors in mitochondrial
apoptosis pathway and cell cycle regulatory pathway, and may negatively regulate
JAK/STAT3 through down-regulating p-Stat3.
The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in
Several Diseases
Authors: Wang Caiyan , Zhang Xuerong , Li Shehan , Li Zibo , Cheng Liangkai , Liu Zhongqiu
Published: April 2022

Heat shock protein (Hsp) 90 is an ATP-dependent chaperone and plays a vital role in the folding, maturation, and stability of a protein. Hsp90 and its client proteins have become targets of various diseases through the regulation of disease-related proteins. Inhibition of Hsp90 production and activity prevents ATP hydrolysis, resulting in the ubiquitination and proteasome degradation of client proteins. However, the Hsp90 inhibitor has obvious toxic side effects and the inevitable heat shock response. Cell division cycle 37 (Cdc37) is a crucial Hsp90 kinase-specific co-chaperone, which forms a complex with Hsp90 to regulate kinase and non-kinase client’s activities, cell commu-nication, and signal transduction. The Hsp90-Cdc37 complex maintains cell survival by stabilizing abnormal client proteins and regulating cell growth signals. The abnormal activation of Hsp90-Cdc37 protein-protein interaction (PPI) often leads to the aggravation of diseases, such as cancer and neuro-degenerative diseases. Compared with ATP competitive Hsp90 inhibitors, blocking Hsp90-Cdc37 PPI has higher selectivity, fewer toxic side effects, and better application prospects. This review detailed the biological characteristics of Hsp90-Cdc37 PPI and its role in several human diseases. Besides, the latest research progress in inhibitors is summarized and discussed to guide further research and clini-cal application.
A Review on Exploring the Opportunities of Polymer Drug Conjugated
Systems for Targeted Cancer Treatment
Authors: Ambre Premlata , Gupta Chandan , Naik Isha , Menon Mala , Coutinho Evans
Published: April 2022

Polymeric drug conjugates (PDCs) for cancer therapy have been a hot research topic for the
past three decades. Successful examples of PDC conjugates have demonstrated sustained drug release
action with decreased systemic toxicity and enhanced tumor retention effect (EPR) via active as well as
passive targeting mechanisms. Therefore, the PDC approach has now become a keystone of the drug
delivery system for cancer and other diseases. In recent years, several PDCs have successfully made up
to the clinical trials. The approach aids targeted delivery of the anticancer drugs to the tumor site without
disturbing the healthy cells. The selection of the over-expressed receptor and the receptor-ligand
plays a vital role in designing the receptor-targeting PDC so that it is able to distinguish between the
healthy cell and the tumor cell. Continuous efforts are being made in research and development toward
an active targeted PDC delivery system to revolutionize cancer treatment despite the controversy built
due to heterogeneity in tumor models. This review highlights the chemistry aspects involved in the
preparation of PDCs that deal with novel molecular tumor targets and strategies used for the development
of targeted PDCs for delivering the drug payload via active or passive targeting. Furthermore, it
sheds light on the challenges faced by targeted PDCs as novel drug delivery systems.
Effects of Combined Garcinia kola and Kigelia africana on Insulin and
Paraoxonase 1 (PON1) Levels in Type 2 Diabetic Rats
Authors: Omoaghe Adams , Oyesola Olusoji , Ezike Tony , Omizu Blessing , Boone Kukoyi
Published: April 2022

Background:

Individual extracts of Garcinia kola and Kigelia africana have been shown to
have therapeutic effects against a variety of variables linked to the development of diabetes mellitus.
However, there is still a lack of information about the combined effects of these extracts on Insulin
and Paraoxonase 1 (PON-1) in Streptozotocin-Nicotinamide-induced type-2 diabetic Wistar rats.

Methods:

Forty-two young male rats (180-200g) were randomly divided into six groups (n = 7/group).
Diabetes was intraperitoneally induced with 110 mg/kg of nicotinamide constituted in distilled water
and fifteen minutes later with 65 mg/kg of streptozocin freshly prepared in 0.1M citrate buffer (pH of
4.5) and treated for six weeks as follows: the control rats received either 0.9% normal saline (NS) or
250 mg/kg extract by gavage. The remaining animals were diabetes induced and subsequently treated
with either NS, graded doses of the extract (250 mg/kg and 500 mg/kg), or 5 mg/kg Glibenclamide +
100mg/kg Metformin. Gas chromatography-mass spectrometry (GCMS) of the combined extracts was
also analyzed to identify the bioactive compounds present in it. Insulin, PON-1 levels, lipid profiles,
and atherogenic index were assessed.

Results:

Our findings show that Insulin and PON-1 levels in the plasma of diabetic rats treated with
the combined extracts were significantly increased when compared to the control rats. Moreover, the
GCMS of the extract shows the presence of both monounsaturated (oleic acid) and polyunsaturated
(linoleic acid) fatty acids.

Conclusion:

The current findings suggest that the extract may help improve glucose homeostasis and
prevent atherosclerosis through the established mechanism of the identified bioactive compounds.
Concise Synthesis of Goniothalesdiol A
Authors: Zeng Ping Li , Zhou Junhui , Yang Xuechao , Wang Dong , Dong Zhibing
Published: April 2022

A concise and efficient synthesis of styryllactone derivative, goniothalesdiol A, has been
achieved in the six longest linear steps with 17.7% overall yield. The key steps of our synthesis involved
PdCl2-mediated Wacker-type oxidative cyclisation and one-pot tandem Wittig olefination-
Michael addition.
Evaluation of Different Signal Peptides for Secretory Production of
Recombinant Human Interferon-gamma: Bioinformatics Approach
Authors: Ghoshoon Mohammad Bagher , Nezafat Navid , Ghoshoon Niloofar , Ghasemi Younes , Jahandar Hoda
Published: April 2022

Background:

The fusion of the secretory signal peptide to the N-terminal of polypeptide’s amino acid sequence is an attractive technique for the secretory production of heterologous proteins. On the other hand, applying computational analysis may be beneficial to overcome the barriers of trial-and-error approaches in detecting proper signal sequences.
As the scope of this study, the most probable effective properties of 30 signal sequences for the extracellular production of recombinant human interferon-gamma (rhIFN-γ) were analysed.

Methods:

The fusion of the secretory signal peptide to the N-terminal of a polypeptide’s
amino acid sequence is an attractive technique for the secretory production of heterologous proteins. On
the other hand, applying computational analysis may be beneficial in overcoming the barriers of trial-anderror
approaches in detecting proper signal sequences.
As the scope of this study, the most probable effective properties of 30 signal sequences for the extracellular
production of recombinant human interferon-gamma (rhIFN-γ) were analysed.

Results:

Finally, 12 high probable signal peptides, including OmpC, PhoE, AnsB, and OmpA, were theoretically
detected with ideal solubility probabilities and almost balanced physicochemical properties;
hopes to be helpful in future experimental studies for the secretion of rhIFN-γ.

Conclusion:

The experimental analysis is required to validate the in silico results and focus on in-lab
affecting factors such as cultivation methods and conditions.
A Review on Experimental Models to Test Medicinal Plants on Postprandial
Blood Glucose in Diabetes
Authors: Abid Sanae , Bnouham Mohamed
Published: April 2022

Due to the gravity of postprandial hyperglycemia in the development of microvascular
and macrovascular diseases in diabetics, many medicinal plants are tested to determine their effectiveness
in glycemic control and the mechanisms of action of the products. Consequently, various
diabetic models have been developed and enhanced over the years.

:

The objective of this review is to describe some of the experimental models to study the effect of
medicinal plants used to control postprandial hyperglycemia.

:

Data was collected from PubMed, ScienceDirect, Scopus, and Google scholar (1953-2021). Fiftyseven
(57) studies were included in this review article.

:

Ten models were identified and described. For each model, we described the targets involved and
their roles in postprandial blood glucose control. The experimental design and procedures described
the targets such as an α-glucosidase enzyme, SGLT1, GLUT2, DPP-IV, Na+/K+ ATPase
pump, or intestinal motility in the models, experiment design and procedures were described.

:

This review will facilitate the selection of the most appropriate model for studying agents used to
investigate postprandial blood glucose.
Genetic Variants of HLA-DRB1 Alleles and the Chance of Developing
Rheumatoid Arthritis: Systematic Review and Meta-Analysis
Authors: Mengesha Birga A. , Ning Lin , Huang Jian
Published: April 2022

Background:

Rheumatoid Arthritis (RA) is more common in those who have specific genetic
types of Human Leukocyte Antigen (HLA). One of the most important genetic risk factors for RA
lies in the HLA-DRB1 locus.

Objective:

This review aimed to determine which HLA-DRB1 alleles were associated with the risk of
RA per allele and phenotype group.

Method:

Statistical analyses were performed using RevMan version 5.4.1.

Results:

The meta-analysis included nine articles that involved 3004 RA patients and 2384 healthy controls.
In the allele group, the frequencies of three HLA-DRB1 alleles, HLA-DRB1*10 (OR = 1.88,
95%CI = 1.25–2.83, p = 0.002), HLA-DRB1*04 (OR = 2.38, 95%CI = 1.73–3.29, p < 0.00001), and
HLA-DRB1*01 (OR = 1.32, 95%CI = 1.08–1.61, p = 0.006), were considerably higher in RA patients
than in controls, and these alleles potentially increased the chance of disease development. Five HLADRB1
alleles (*03, *07, *11, *13, and *14), were more prevalent in healthy people than in RA patients
and may therefore offer protection against disease onset. Only the DRB1*04 subtypes, DRB1*0401
(OR = 1.37, 95 percent CI = 1.05–1.79, p = 0.02) and DRB1*0404 (OR = 1.73, 95% CI = 1.19–12.53, p
= 0.004), showed a significant association with the risk of RA in our pooled effect.

Conclusion:

Our findings demonstrated a significant relationship between HLA-DRB1 and the risk of
RA in various ethnic groups.
Systemic and Anticancer Potential of Adaptogenic Constituents Isolated from Traditional
Herbs – A Mini-Review
Authors: Sulaiman Mahaboob Khan , Lakshmanan Jaganathan
Published: April 2022

Adaptogens were initially recognized as stress-resistance inducing compounds. Recent studies reveal that
adaptogens are pleiotropically-acting chemical constituents that can be isolated from traditional herbs. They are gaining
increasing attention in cancer chemotherapy. This review summarizes the physiological action of adaptogens isolated
from the 9 most widely used traditional herbs implicated in cancer therapy viz., Withania somnifera, Tinospora
cordifolia, Rhodiola rosea, Emblica officinalis, Glycyrrhiza glabra, Bacopa monnieri, Asparagus racemosus, Ocimum
sanctum, and Panax notoginseng. The studies were identified through a systematic search of major computerized databases
such as Pubmed, Embase, Medline, Inflibnet, Google Scholar, and Cochrane Library. Individual names of each
herb and biological action were the search terms employed. In this review, we have enlisted the chemical constituents
and their mechanism of action in a few organ systems as well as in cancer cells. Studies indicate that the adaptogens
isolated from these herbs can be broadly arranged into 2 classes based on their chemical structure. These molecules
exert a positive influence on several organ systems such as respiratory, nervous, cardiovascular, immune, and gastrointestinal
tracts. It is also clear that adaptogens act as effective chemopreventive agents alone or in combination with
chemo drugs in multiple cancers by targeting multiple intracellular target proteins. Therefore, we conclude that adaptogens
are versatile ligands capable of eliciting many systemic effects. Their biological functions are complex, varied,
and context-dependent in various cancers. This offers great scope for personalized treatment and cancer chemoprevention
in the future.
COVID-19 Associated Rhino-Orbital-Cerebral Mucormycosis: A Proposed
Classification and Treatment Strategies
Authors: Kant Singh Namit , Hage Neemu , Ramamourthy Balaji , Medha Kappagantu Krishna
Published: April 2022

Objective:

Mucormycosis is a rare fungal disease and was known to affect only immunocompromised hosts, but in the COVID 19 pandemic, a surge in the cases of Rhino- Orbital-Cerebral Mucormycosis have been reported, and the cause still unknown. As the disease was a rare entity there was no classification considering the sprerad and proper management at various stages of spread.

Method:

Extensive literature search with the terms “ Mucormycosis”, “Invasive Fungal Sinusitis” and “COVID 19 associated Mucormycosis”, “Mucormycosis in COVID” was made on Pubmed, Scopus and Embase database, taking into consideration case histories revealing the site of involvement and treatment according to the extension of the disease

Results:

Relevant articles were analysed and it was found that there is no specific classification of the disease entity and proper surgical and medical management guidelines to date and the disease spread followed a pattern related to the first site of involvement and few reports also suggested skip lesions.

Conclusion::

This review is an attempt through which, we elaborate the pathophysiology of Mucormycosis and its spread and propose a classification which will be helpful in determining policies for control and prevent complications, morbidity, and mortality.
Literature Review on the Use of Herbal Extracts in the Treatment of Non-
Alcoholic Fatty Liver Disease
Authors: Wang Yutian , Wu Junzi , Shi Anhua
Published: April 2022

Background:

Non-alcoholic fatty liver disease is a common chronic liver injury disease, and its
incidence is rapidly increasing across the globe, thus becoming a serious threat to human health.
So far, the clinical prevention and treatment of non-alcoholic fatty liver disease mainly include
single-targeted drug therapy, surgical treatment and lifestyle changes. However, these treatments
cannot completely address the complex pathogenesis of non-alcoholic fatty liver disease and have
various side effects. Recent studies reveal that many herbal extracts are found to have potential
anti-non-alcoholic fatty liver disease activities.

Objective:

This paper presents a review on herbal extracts used for the treatment of non-alcoholic
fatty liver disease in experimental studies to provide a theoretical basis for their clinical application
in the treatment of non-alcoholic fatty liver disease and for new drug development.

Methods:

Scientific papers were retrieved by searching the PubMed database up to Feb 2021 using
the following keywords: ‘non-alcoholic fatty liver disease’, ‘herbal extracts’ (‘flavonoids’,
‘saponins’, ‘quinones’, ‘phenolic compounds’, ‘alkaloids’, ‘polysaccharides’, ‘ginkgolide B’,
‘schizandrin B’, ‘ursolic acid’) and ‘mechanism’.

Results:

The pharmacological effects and mechanisms of many herbal extracts can reverse the
adverse health effects of non-alcoholic fatty liver disease.

Conclusion:

In vitro and in vivo experimental studies indicated that herbal extracts can improve the
symptoms of non-alcoholic fatty liver disease by inhibiting inflammation, antioxidant stress,
improvement of lipid metabolism and insulin sensitivity and regulating intestinal bacteria flora.
However, there needs to be sufficient data from human clinical trials to prove their efficacy and
safety.
Alzheimer's Disease: A Silent Pandemic - A Systematic Review on
the Situation and Patent Landscape of the Diagnosis
Authors: Goyzueta-Mamani Luis Daniel , Chávez-Fumagalli Miguel Angel , Alvarez-Fernandez Karla , Aguilar-Pineda Jorge A. , Nieto-Montesinos Rita , Davila Del-Carpio Gonzalo , Vera-Lopez Karin J. , Lino Cardenas Christian L.
Published: April 2022

Background:

Alzheimer's disease (AD) is characterized by cognitive impairment,
tau protein deposits, and amyloid beta plaques. AD impacted 44 million people in
2016, and it is estimated to affect 100 million people by 2050. AD is disregarded as a pandemic
compared with other diseases. To date, there is no effective treatment or diagnosis.

Objective:

We aimed to discuss the current tools used to diagnose COVID-19, point out
their potential to be adapted for AD diagnosis, and review the landscape of existing patents
in the AD field and future perspectives for AD diagnosis.

Method:

We carried out a scientific screening following a research strategy in PubMed;
Web of Science; the Derwent Innovation Index; the KCI-Korean Journal Database; Sci-
ELO; the Russian Science Citation index; and the CDerwent, EDerwent, and MDerwent
index databases.

Results:

A total of 326 from 6,446 articles about AD and 376 from 4,595 articles about
COVID-19 were analyzed. Of these, AD patents were focused on biomarkers and neuroimaging
with no accurate, validated diagnostic methods, and only 7% of kit development patents
were found. In comparison, COVID-19 patents were 60% about kit development for
diagnosis; they are highly accurate and are now commercialized.

Conclusion:

AD is still neglected and not recognized as a pandemic that affects the people
and economies of all nations. There is a gap in the development of AD diagnostic tools that
could be filled if the interest and effort that has been invested in tackling the COVID-19
emergency could also be applied for innovation.
L-Glutamic Acid Mitigates Carbon Tetrachloride-Induced Acute Tissue
Injury by Reducing Oxidative Stress in a Rat Model
Authors: Salyha Nataliya , Salyha Yuriy
Published: April 2022

Background:

Tetrachloromethane (CCl4) is a highly toxic environmental pollutant that
causes specific and serious damage to various organs of animals and humans. The study of its effect
on physiological and biochemical processes in the mammalian organism is very important, despite the
severe restrictions on the use of tetrachloromantane in recent years. The fact is that they can be used as
a model for many toxicological studies.

Objective:

The experimental studies aimed at exploring the ameliorative effects of L-glutamic acid (LGlu)
on CCl4 toxicity in the myocardium, lung tissues and blood of male rats.

Methods:

Rats were exposed to CCl4, and later rats were treated with L-Glu. The GSH level and the
activities of antioxidant enzymes were studied. In addition to this, the content of lipid peroxidation
products was monitored.

Results:

The obtained results suggest that CCl4 causes oxidative stress in rat tissues, accompanied by
an increase in lipid peroxidation products and a decrease in glutathione peroxidase (GPx), glutathione
reductase (GR), glutathione transferase (GST), glucose-6-phosphate dehydrogenase (G6PDH), superoxide
dismutase (SOD), catalase (CAT) activities and reduced glutathione (GSH) content. The enzymatic
activity in tissues of rats treated with L-Glu was restored. Moreover, the changes, which were
observed in the studied parameters, showed to be less significant compared to CCl4 treated group.

Conclusion:

These results suggest that L-Glu inhibits free radical processes. In summary, this study
demonstrates the feasibility of the administration of L-Glu supplementation, which could be used to
protect and mitigate the CCl4-induced oxidative stress.
Natural legal and positive legal attitudes as an element of legal consciousness
Authors:   L.V. Karnaushenko KrasnodarUniversity of the Russian MIA, Karnaushenko L.V.
Published: April 2022

The problem of the relationship between the theories of natural and positive law is considered mainly in the framework of the analysis of the contradiction between them. This is facilitated by the fact that the discussion between supporters of natural law and positive law theory is incomplete. However, these paradigms are not only of important theoretical and methodological importance. They are, above all, a way of thinking about law. And it is of great importance that certain elements of positive legal and natural legal theories become public knowledge and influence the legal consciousness. In this context, it is found advisable to study the influence on the legal consciousness of elements of positive legal and natural legal theories. The methodological foundations of the work include analysis, comparison, abstraction, institutional and socio-phenomenological approaches. Within the framework of the study, the main aspects of natural-legal and positive-legal theories are identified. It is justified that the natural legal framework in the consideration of law is characterized by selective adoption of the rules of law and, at the same time, their value justification. In turn, a positivist approach to the consideration of law contributes to the adoption of a system of legal norms as a whole, but is characterized by a significant formalism.
Some problems of implementing the right of citizens to meetings, rallies, demonstrations, races and picketing in the Russian Federation and foreign countries
Authors:   S.N. Keramova Dagestan State University, Keramova S.N.
Published: April 2022

The article examines the main problems that exist in the process of realizing the right of citizens to hold meetings, rallies, demonstrations, processions and pickets in the Russian Federation. The purpose of the study is to find a solution to the problems that arise when citizens exercise their right to public events. The features of the organization, implementation and termination of these events are analyzed. Examples from judicial practice are given. Attention is paid to the foreign experience of holding public events. Revealed and substantiated the need to improve the legislation on public events. The result of the study is the formulation of conclusions that it is necessary, based on the use of the experience of foreign countries, to develop recommendations for the development of legislation in this area.
Some problems of the administrative and procedural process
Authors:   G.M. Musaeva Dagestan State University, Musaeva G.M.
Published: April 2022

Issues related to the administrative process in these conditions are extremely relevant and in demand in conditions when there is a need for the preparation and adoption of an administrative procedural code, which would reflect general provisions on the procedure for considering and resolving administrative procedures in all spheres of public administration. The article examines the problems related to the administrative and procedural activities of executive authorities. The purpose of this study is not to study all the administrative procedures that exist within the framework of executive and administrative activities. The article considers "positive" administrative procedures, with the help of which the activities of executive authorities and their officials are carried out to resolve individual administrative cases of an indisputable positive nature. Cases of a positive indisputable nature are associated with the satisfaction of the vital interests of individuals and legal entities and are aimed at the realization of their rights. The result of the study is the formulation of conclusions that in order to solve the problems of the administrative and administrative process, it is necessary to adopt an administrative procedural code or a law on administrative procedures.
The problem of establishing the origin of children as a legal consequence of the contract on surrogate motherhood
Authors:   K.D. Gaibatova Dagestan State University, Gaibatova K.D. , Shamsudinova P. M. ,   P. M. Shamsudinova Dagestan State University
Published: April 2022

The article identifies and investigates the problems of establishing the origin of children that arise when concluding a surrogacy contract. The question of the origin of children when using surrogate motherhood remains open, but we emphasize that due to the spread of surrogate motherhood, the position that the mother of the child is the woman who gave birth to him has increasingly become questioned. The legislative vision of the situation is revealed, as well as several examples from practice are given, reflecting the pressing problems of Russian legislation in the field of surrogacy. The position expressed by the Constitutional Court of the Russian Federation regarding the determination of the origin of children born through the use of assisted reproductive technologies is mentioned. The example of foreign states and post-Soviet countries is also important. The proposals for improving the legislation are substantiated and put forward.
Ensuring a balance of interests of the participants in the relations in the development of the institute of organ and tissue transplantation in the Russian Federation
Authors:   L. V. Zarapina Russian state University of justice, Zarapina L. V. , Kostina O. V. ,   O. V. Kostina Russian state University of justice
Published: April 2022

The article deals with issues related to the development of the Institute of Human Organ and Tissue Transplantation. The issues of transplantation currently cause numerous discussions both in the theory of law and in practice, in connection with which the main task of developing relations is to ensure a balance of interests of the persons involved in these relations. The authors seek to dwell not only on the issues of the genesis of the institution under consideration, but also to show the importance of further development of the legal regulation of the aspects raised in the study
Helping Children to Participate in Human Papillomavirus–Related Discussions: Mixed Methods Study of Multimedia Messages (Preprint)
Authors: Occa Aurora , Stahl Hayley M , Julien-Bell Sarah
Published: April 2022

BACKGROUND

Human papillomavirus (HPV) can cause several types of cancers and genital warts. A vaccine is available to prevent HPV infections, and several efforts have been made to increase HPV education and, eventually, vaccination. Although previous studies have focused on the development of messages to educate children about HPV and the existence of the HPV vaccine, limited research is available on how to help children better communicate with their parents and health care professionals about the HPV vaccination. In addition, limited research is available on the target audience of this study (Italian children).

OBJECTIVE

This manuscript describes a study assessing the feasibility of using an evidence-based animated video and a web-based game to help children (aged 11-12 years) participate in discussions about their health—in particular when such conversations center around the HPV vaccination—and improve several HPV-related outcomes. The study also compares the effects of these 2 educational multimedia materials on children’s knowledge and perceptions of HPV prevention.

METHODS

A mixed methods approach consisting of focus group discussions and an experiment with children (N=35) was used to understand children’s experiences with, and perceptions of, the animated video and the game and to measure possible improvements resulting from their interaction with these materials.

RESULTS

Both the animated video and a web-based game increased children’s knowledge and positive perceptions about HPV and HPV vaccination. Any single message was not more effective than the others. The children discussed aspects of the features and characters they liked and those that need improvements.

CONCLUSIONS

This study shows that both materials were effective for improving children’s education about the HPV vaccine and for helping them to feel more comfortable and willing to communicate with their parents and health care professionals about their health. Several elements emerged that will allow further improvements in the design and development of the messages used in this study as well as the creation of future campaigns.
The Impact and Applications of Social Media Platforms for Public Health Responses Before and During the COVID-19 Pandemic: Systematic Literature Review (Preprint)
Authors: Gunasekeran Dinesh Visva , Chew Alton , Chandrasekar Eeshwar K , Rajendram Priyanka , Kandarpa Vasundhara , Rajendram Mallika , Chia Audrey , Smith Helen , Leong Choon Kit
Published: April 2022

BACKGROUND

 Social media platforms have numerous potential benefits and drawbacks on public health, which have been described in the literature. The COVID-19 pandemic has exposed our limited knowledge regarding the potential health impact of these platforms, which have been detrimental to public health responses in many regions.

OBJECTIVE

This review aims to highlight a brief history of social media in health care and report its potential negative and positive public health impacts, which have been characterized in the literature.

METHODS

 We searched electronic bibliographic databases including PubMed, including Medline and Institute of Electrical and Electronics Engineers Xplore, from December 10, 2015, to December 10, 2020. We screened the title and abstracts and selected relevant reports for review of full text and reference lists. These were analyzed thematically and consolidated into applications of social media platforms for public health.

RESULTS

 The positive and negative impact of social media platforms on public health are catalogued on the basis of recent research in this report. These findings are discussed in the context of improving future public health responses and incorporating other emerging digital technology domains such as artificial intelligence. However, there is a need for more research with pragmatic methodology that evaluates the impact of specific digital interventions to inform future health policy.

CONCLUSIONS

 Recent research has highlighted the potential negative impact of social media platforms on population health, as well as potentially useful applications for public health communication, monitoring, and predictions. More research is needed to objectively investigate measures to mitigate against its negative impact while harnessing effective applications for the benefit of public health.
Peer Review of “Left Ventricular Outflow Tract Obstruction in Patients Treated With Milrinone for Cerebral Vasospasm: Case Report and Literature Review” (Preprint)
Authors: Munakomi Sunil
Published: April 2022

UNSTRUCTURED

This is a peer review report related to MS#31019
Pendidikan Tata Krama dan Sopan Santun dalam Pertunjukan Tari Klasik Gaya Yogyakarta di Bangsal Srimanganti Keraton Yogyakarta
Authors: Pradana Cerry Surya , Setyastama R
Published: April 2022

Yogyakarta merupakan satu di antara beberapa destinasi wisata unggulan di Indonesia. Keunikan dan kelebihankegiatan pariwisata di Yogyakarta, terletak pada budaya lokal yang ada di dalamnya. Di antara budaya lokal tersebut,Tari Klasik Gaya Yogyakarta atau Joged Mataram adalah salah satu daya tariknya. Tarian ini diciptakan oleh SriSultan Hamengku Buwono I, sebagai tarian sakral di Keraton Yogyakarta. Dulunya, tarian ini eksklusif menjadimilik Keraton Yogyakarta, namun sejak masa Sri Sultan Hamengku Buwono VII, masyarakat umum dapat berlatihdan mementasankannya. Bahkan sejak masa pemerintahan Sri Sultan Hamengku Buwono IX, tarian ini dijadikanpertunjukan wisata bagi para wisatawan yang datang ke Keraton Yogyakarta. Tarian ini juga mengandung nilai tatakrama dan sopan santun serta etika, baik sebelum, ketika, maupun setelah pementasan. Hingga saat ini, nilai-nilaitersebut tidak hilang bahkan jika hanya digunakan untuk berlatih. Penelitian ini menggunakan metode penelitiandeskriptif dan analisis menggunakan beberapa variabel terkait penelitian. Data diperoleh melalui observasi danwawancara secara mendalam, di samping menggunakan pustaka terkait. Hasil dari penelitian ini, Tari Klasik GayaYogyakarta merupakan kesenian yang sarat nilai dan memiliki nilai di dalamnya. Nilai tersebut berkaitan denganpendidikan tata krama, sopan santun, dan etika. Nilai-nilai ini secara spesifik terkandung pada cara berbicara, caramenempatkan diri, dan cara menghormati orang lain.
PENGARUH KOMUNIKASI POLITIC ENTERTAINMENT MELALUI IKLAN TERHADAP TINGKAT KETERPILIHAN PARTAI POLITIK PADA PEMILIHAN UMUM 2019
Authors: Firmansyah Muhamad Ferdy
Published: April 2022

Globalization demands the development of communication media, which is TV advertisment. Indonesian political dynamics is one of the most unique and fresh studies discussed in various perspectives. It concerns ondecision making and ethical political differentiation that empirically influences the political legitimacy in political representation. Digital politics is very popular within the society it could be categorized as swing voters. Digital politic is growing close to the 2019 general election as the effort of low politics tendencies that can be analyzed using the cultural value. Political parties have a polarization to use TV advertisement to be a media for socialization their political goals. The implementation of this style is usually called politics entertainment. This research explains the influence of digital political style and entertainment politics with TV advertisement on the level of electability of political parties in the general election 2019 through data interpretation method. The research is conducted as a means to explain the understanding ofmass polarization in online setting. Additionally, it is also purposed to know the effectiveness of digital politics and entertainment politics in its use in the 2019 general election.
Persaingan Kekuatan Saudi Arabia (Sunni) Dan Iran (Syiah) Pada Kasus Konflik Kontemporer (Suriah Dan Yaman)
Authors: Maulana Muhamad Syahdy
Published: April 2022

Penelitian ini membahas tentang kompetisi kekuatan antara Saudi Arabia (Sunni) dan Iran (Syiah) dengan melihat keterlibatan kedua negara tersebut dalam mewujudkan ekspansi pengaruh Timur Tengah dengan menggunakan pendekatan ideologi. Hal tersebut bertujuan sebagai penyeimbang kekuatan kedua negara tersebut di kawasan Timur Tengah, khususnya pada kasus Suriah dan Yaman. Penelitian ini menggunakan teori balance of powerdan pendekatan ideologi untuk mengidentifikasi pola konflik dan pendekatan yang dimainkan oleh kedua negara tersebut. Tujuan penelitian ini adalah untuk mengetahui latar belakang konflik di antara kedua negara tersebut yang menggunakan pendekatan ideologi untuk menggapai tujuan politiknya. Penelitian ini menggunakan pendekatan deskriptif-analitik dalam menjawab permasalahan dalam penelitian dimaksud. Penelitian ini menunjukkan bahwa Saudi Arabia dan Iran memainkan peran yang sangat signifikan pada konflik Suriah dan Yaman dalam berbagai cara, seperti pendanaan dan pemberikan bantuan logistik militer. Pendekatan ideologi tidak pernah lepas dari misi yang dijalankan oleh kedua negara tersebut. Dalam keberhasilannya, sejauh ini Iran berhasil dalam membangun aliansi dengan pemerintah lokal, sehingga Iran mendapatkan kemenangannya di Yaman. Namun tidak dengan Saudi Arabia yang walaupun negara tersebut telah membangun aliansi dengan berbagai cara, akan tetapi sejauh ini tidak menunjukan keberhasilannya.
INOVASI PEMERINTAH DAERAH JOGJA SMART SERVICE DALAM MENCIPTAKAN SMART AND LIVEABLE CITY DI KOTA YOGYAKARTA
Authors: Gumilar Muhammad Gilang
Published: April 2022

Pemerintah Daerah Kota Yogyakarta menyediakan aplikasi Jogja Smart Service untuk mempermudah masyarakat dalam memperoleh informasi terintegrasi. Penelitian ini bertujuan; 1) mengidentifikasi penyediaan informasi pelayanan publik yang terintegrasi dalam inovasi pemerintah daerah berbentuk aplikasi web dan smartphone Jogja Smart Service, 2) mengnalisis bagaimana optimalisasi pemanfaatan aplikasi Jogja Smart Service. Metode penelitian yang digunakan adalah kualitatif. Data sekunder diperoleh melalui laporan instansi dan fitur aplikasi melalui smart phone.Teknik analisis yang digunakan adalah deskriptif kualitatif. Hasil penelitian menunjukkan bahwa Aplikasi jogja smart service terdiri atas informasi terintegrasi dengan penyajian informasi berupa visual, deskripsi yang terintegrasi dengan ruang dan lokasi dalam bentuk peta dan augmented reality. Pemanfaatan Aplikasi Jogja Smart Service  melalui pemantauan sistem menunjukkan pemanfaatan yang baik. Selain itu, perlu belum optimalisasi pemanfaatan aplikasi oleh masyarakat luas. Strategi pengenalan dan sosialisasi Aplikasi Jogja smart service diperlukan dalam mewujudkan Kota Yogyakarta yang smart and liveable city.Kata kunci: Aplikasi, Informasi Terintegrasi, Inovasi,  Smart and liveable city
ИЗМЕРЕНИЕ ПЕРЕМЕЩЕНИЯ С ПОМОЩЬЮ ПОДВИЖНОЙ ГОЛОГРАФИЧЕСКОЙ ДИФРАКЦИОННОЙ РЕШЕТКИ В ИНТЕРФЕРЕНЦИОННОМ ПОЛЕ
Authors: Турухано Б.Г. , Турухано Н. , Турухано И.А.
Published: April 2022

Чем выше требуется точность определения длины или угла поворота объекта или вели-
чины его перемещения, с помощью линейных и угловых датчиков, тем выше требования к их точно-
сти и разрешению. Линейные и угловые голографические датчики (ЛГД и УГД) на базе голографических
дифракционных решеток (ГДР) по своим характеристикам, в настоящее время, достигли нанодиапазона
точностей.
ПРОВОДИМОСТЬ КАНАЛОВ РОТОРНОГО МЕХАНИЗМА ДВУХРОТОРНОГО ВАКУУМНОГО НАСОСА ТИПА РУТС ПРИ МОЛЕКУЛЯРНОМ РЕЖИМЕ ТЕЧЕНИЯ ГАЗА
Authors: Исаев А.А. , Райков А.А. , Бурмистров А.В. , Саликеев С.И.
Published: April 2022

С помощью метода угловых коэффициентов, реализованного в пакете COMSOL Multiphysics, рассчитана суммарная проводимость щелевых каналов роторного механизма двухроторного вакуумного насоса типа Рутс. Проведено сравнение полученных расчетных данных с экспериментальными значениями, полученными путем продувки насоса ДВН-50 при различных углах поворота роторов. Отмечается достаточно хорошая сходимость результатов расчета и эксперимента.
ЭЛЕКТРОФОРМОВАНИЕ СИНТЕТИЧЕСКИХ ВОЛОКОН И ИХ ПРИМЕНЕНИЕ (ОБЗОР)
Authors: Колобков А.С.
Published: April 2022

Электроформование – это универсальный и гибкий метод получения ультратонких волокон. Волокна, получаемые с помощью электроформования, используются во многих отраслях промышленности. Благодаря высокому соотношению длины волокна к его площади особенно большое применение электроформование нашло в производстве фильтрующих материалов, на основе ультратонких синтетических волокон.
Disease Prediction using Machine Learning
Authors: G Magilan , K Swaitha , R Sarath Vijay , B Jona J.
Published: April 2022

Abstract: It is a system which provides the user the information and tricks to take care of the health system of the user and it provides how to search out the disease using this prediction. Now a day’s health industry plays major role in curing the diseases of the patients so this is often also some quite help for the health industry to inform the user and also it's useful for the user just in case he/she doesn’t want to travel to the hospital or the other clinics, so just by entering the symptoms and every one other useful information the user can get to grasp the disease he/she is affected by and also the health industry may also get enjoy this method by just asking the symptoms from the stoner and entering within the system and in only many seconds they'll tell the precise and over to some extent the accurate conditions. This Disease Prediction Using Machine Learning is totally through with the assistance of Machine Learning and Python programming language and also using the dataset that's available previously by the hospitals using that we are going to predict the diseases. Keywords: Prediction, Decision Tree, Random forest, Naive Bayes
Flood Prediction Using ML Classification Methods on Rainfall Data
Authors: Sivamoorthy Thegeshwar , Ansari Asif Mohammed , Sivakumar Dr. B. , Nallarasan V.
Published: April 2022

Abstract: Floods are among the most destructive, most complex natural disasters to mimic. Research on the development of flood forecast models has contributed to risk reduction, a policy proposal, reduction of human lives, and mitigation of flood-related property damage. To mimic the complex statistical manifestations of natural flood processes, over the past two decades, neural network approaches have contributed significantly to the development of predictive systems that provide better performance and cost-effective solutions. To prevent this problem predict the occurrence of floods or not with a rain database by investigating neural network-based strategies. Database analysis by Multi-Layer Perceptron Classifier (MLP) to capture a number of details such as dynamic identification, deficit treatment, data validation, and data cleaning/preparation will be done across the given database. To apply flood forecasts for or without accurate calculation in the class division report, find the confusion matrix and the result shows the efficiency of the python frame-based flask based on the given attributes. Keywords: Flood forecast, decision tree, Random Forest, Descent, SVM, Flasks.
Reengineering of territories and built-up areas: a conceptual framework
Authors: Sborshchikov Sergej B. , Zhuravlev Pavel A.
Published: April 2022

Introduction. The development of built-up urban areas, aimed at improving the living arrangements and standards, is implemented within the boundaries of an element of a structural plan, as well as related elements. It is important, since it affects the interests of a substantial part of the country’s population. The achievement of the goals, pursued by the national projects and programmes as socio-economic development tools, depends directly on the effective development of built-up areas. The effective development of built-up areas involves comprehensive transformation and modernization of territories and buildings on the basis of the concept of reengineering of territories and built-up areas, including methods of effective and high-quality change management.

Materials and methods. The subject of the study is a set of measures that ensure the qualitative transformation of engineering (technological) solutions and serve as the backbone structure of reengineering in construction. The object of the study is the process of qualitative transformation of technological (technical) solutions and business processes (management decisions). It is noted that the actual focus of transformation of territories and built-up areas is implemented in the course of actions, taken within the framework of reengineering of technological processes (technical solutions), including the stages of reconstruction, renovation, technical retooling, repurposing, and reclamation. The factors, influencing the reengineering of management solutions, are provided. Features of the composition and properties of the reengineering of territories and built-up areas, characteristic of its practical implementation, are presented. Research methods include structural and functional analyses.

Results. Current fundamental differences in the nature of regulatory impacts accompanying the traditional type of restoration (modernization), as well as impacts, made within the framework of reengineering of territories and built-up areas, are described. The authors suggest that the integrated approach of impacts, made in the process of reengineering of territories and built-up areas, is conveyed in the relationship between “property development – capital construction facilities – a technological solution”, as well as the scope and intensity of impacts. The general framework for the concept, underlying the implementation of the reengineering of territories and built-up areas, is presented.