bluuebunny/crossref_metadata_2025 huggingface dataset:
First trimester use of artemisinin-based combination therapy and the risk of low birth weight and small for gestational age
Authors: Augusto Orvalho , Stergachis Andy , Dellicour Stephanie , Tinto Halidou , Valá Anifa , Ruperez Maria , Macete Eusébio , Nakanabo-Diallo Seydou , Kazienga Adama , Valéa Innocent , d’Alessandro Umberto , ter Kuile Feiko O. , Calip Gregory S. , Ouma Peter , Desai Meghna , Sevene Esperança
Published: April 2020

Background

While there is increasing evidence on the safety of artemisinin-based combination therapy (ACT) for the case management of malaria in early pregnancy, little is known about the association between exposure to ACT during the first trimester and the effect on fetal growth.

Methods

Data were analysed from prospective studies of pregnant women enrolled in Mozambique, Burkina Faso and Kenya designed to determine the association between anti-malarial drug exposure in the first trimester and pregnancy outcomes, including low birth weight (LBW) and small for gestational age (SGA). Exposure to anti-malarial drugs was ascertained retrospectively by record linkage using a combination of data collected from antenatal and adult outpatient clinic registries, prescription records and self-reported medication usage by the women. Site-level data synthesis (fixed effects and random effects) was conducted as well as individual-level analysis (fixed effects by site).

Results

Overall, 1915 newborns were included with 92 and 26 exposed to ACT (artemether–lumefantrine) and quinine, respectively. In Burkina Faso, Mozambique and Kenya at recruitment, the mean age (standard deviation) was 27.1 (6.6), 24.2 (6.2) and 25.7 (6.5) years, and the mean gestational age was 24.0 (6.2), 21.2 (5.7) and 17.9 (10.2) weeks, respectively. The LBW prevalence among newborns born to women exposed to ACT and quinine (QNN) during the first trimester was 10/92 (10.9%) and 7/26 (26.9%), respectively, compared to 9.5% (171/1797) among women unexposed to any anti-malarials during pregnancy. Compared to those unexposed to anti-malarials, ACT and QNN exposed women had the pooled LBW prevalence ratio (PR) of 1.13 (95% confidence interval (CI) 0.62–2.05, p-value 0.700) and 2.03 (95% CI 1.09–3.78, p-value 0.027), respectively. Compared to those unexposed to anti-malarials ACT and QNN-exposed women had the pooled SGA PR of 0.85 (95% CI 0.50–1.44, p-value 0.543) and 1.41 (95% CI 0.71–2.77, p-value 0.322), respectively. Whereas compared to ACT-exposed, the QNN-exposed had a PR of 2.14 (95% CI 0.78–5.89, p-value 0.142) for LBW and 8.60 (95% CI 1.29–57.6, p-value 0.027) for SGA. The level of between sites heterogeneity was moderate to high.

Conclusion

ACT exposure during the first trimester was not associated with an increased occurrence of LBW or SGA. However, the data suggest a higher prevalence of LBW and SGA for children born to QNN-exposed pregnancies. The findings support the use of ACT (artemether–lumefantrine) for the treatment of uncomplicated malaria during the first trimester of pregnancy.
The long-term evaluation of the prognosis of implants with acid-etched surfaces sandblasted with alumina: a retrospective clinical study
Authors: Kim Min-Joong , Yun Pil-Young , Chang Na-Hee , Kim Young-Kyun
Published: April 2020

Background

The aim of this study was to evaluate the long-term clinical stability of implants with acid-etched surfaces sandblasted with alumina using retrospective analyses of the survival rate, success rate, primary and secondary stability, complications, and marginal bone loss of the implants.

Methods

Patients who had implants placed (TS III SA, SS II SA, SS III SA, and U III SA) with SA surfaces from Osstem (Osstem Implant Co., Busan, Korea) at the Seoul National University Bundang Hospital, from January 2008 to December 2010 were selected for the study. Patients’ medical records and radiographs (panorama, periapical view) were retrospectively analyzed to investigate sex, age, location of implantation, diameter, and length of the implants, initial and secondary stability, presence of bone grafting, types of bone grafting and membranes, early and delayed complications, marginal bone loss, and implant survival rate.

Results

Ninety-six implants were placed in 45 patients. Five implants were removed during the follow-up period for a total survival rate of 94.8%. There were 14 cases of complications, including 6 cases of early complications and 8 cases of delayed complications. All five implants that failed to survive were included in the early complications. The survival of implants was significantly associated with the occurrence of complications and the absorption of bone greater than 1 mm within 1 year after prosthetic completion. In addition, the absorption of bone greater than 1 mm within 1 year after prosthetic completion was significantly associated with the occurrence of complications, primary stability, and implant placement method. Five cases that failed to survive were all included in the early complications criteria such as infection, failure of initial osseointegration, and early exposure of the fixture.

Conclusions

Of the 96 cases, 5 implants failed resulting in a 94.8% survival rate. The failed implants were all cases of early complications such as infection, failure of initial osseointegration, and early exposure of the fixtures. Peri-implantitis was mostly addressed through conservative and/or surgical treatment and resulted in very low prosthetic complications. Therefore, if preventive measures are taken to minimize initial complications, the results can be very stable.
The first report of the evaluation of the knowledge regarding toxoplasmosis among health professionals in public health centers in Rabat, Morocco
Authors: Laboudi Majda , Ait Hamou Sanaa , Mansour Imane , Hilmi Ilham , Sadak Abderrahim
Published: April 2020

Background

The assessment of the knowledge of Toxoplasma gondii infection among health professionals is essential to design an effective management strategy. The current study was conducted to assess the knowledge and perception of health professionals working in urban public health centers of different parts of Rabat in Morocco.

Methods

A cross-sectional study was conducted from March 15 to June 15, 2017, in urban public health centers selected in the prefecture of Rabat in Morocco. A structured questionnaire was completed by participants and included questions on the epidemiology and diagnosis of toxoplasmosis and clinical issues related to the infection.

Results

Ninety-six health professionals participated, including medical doctors, nurses, midwives, and laboratory technicians. Most of them were female (86, 89.58%). The mean age was 40.51 ± 10.26 years, and the mean length of time working in the field of healthcare was 15.92 ± 8.55 years. Eighty one percent (86, 81.25%) of health professionals knew the agent of toxoplasmosis, and 62 (64.5%) knew the definitive host of the parasite. Regarding clinical symptoms, 55 (57.29%) of the respondents knew that toxoplasmosis is an asymptomatic disease in immunocompetent persons. More than half of the respondents correctly identified the main routes of transmission: eating raw or undercooked meats, unwashed fruits and vegetables, and having direct contact with cats. However, only 29 (30.21%) of them believed that water can be a risk factor for the transmission of toxoplasmosis. Regarding diagnosis, only 14 (14.58%) health professionals knew about the avidity test.

Conclusions

The implementation of educational interventions is recommended to raise awareness of toxoplasmosis among health professionals who provide prenatal care in public health centers.
Design and performance analysis of integrated focusing grating couplers for the transverse-magnetic TM00 mode in a photonic BiCMOS technology
Authors: Georgieva Galina , Voigt Karsten , Peczek Anna , Mai Christian , Zimmermann Lars
Published: April 2020

Focusing grating couplers for the excitation of the fundamental transverse-magnetic (TM) mode in integrated silicon photonic waveguides are designed and characterized under the boundary conditions of a photonic BiCMOS foundry. Two types of waveguide geometries are considered – a nanowire and a rib waveguide. Wafer-scale experimental results for nanowire TM grating couplers are in excellent agreement with numerical investigations and demonstrate a robust behavior on the wafer. The mean coupling loss and the 3σ interval are -3.9 ± 0.3 dB. The on wafer variation is three times lower than for the fundamental transverse-electric (TE) polarization. Similarly, the coupling in rib waveguides is examined as well. The results indicate that the rib waveguides require a modified geometry when designed for TM. In general, the nanowire waveguide type is more suitable for TM coupling, showing a stable and repeatable performance.
A role for MIR828 in pineapple fruit development
Authors: Rock Christopher D.
Published: April 2020

Chen et al. (Nature Genet. 51: 1549–1558; Oct. 2019) sequenced Ananas comosus var. bracteatus accession CB5, cultivated for its bright pink-to-red colored fruit, and yellow-fleshed A. comosus accession F153, reporting an improved F153 reference assembly while annotating MICRORNA (MIRNA) loci and gene family expressions relevant to lignin and anthocyanin biosynthesis. An independent article (Xiong et al. Sci. Rep. 8: 1947; 2018) reported var. bracteatus MIRNAs but not MIR828, a negative regulator of anthocyanin and polyphenolics biosynthesis by targeting MYB transcription factors associated with UV light- and sugar-signaling in dicots. MIR828 has been reported in gymnosperms, Amborella (sister to flowering plants), and basal monocot orders Liliales, Asparagales, Zingiberales, Arecales, but not in the Poales, a sister order comprising grasses and ~3,000 species of bromeliads including pineapple. Here I show MIR828 exists in pineapple and directs post-transcriptional gene silencing of mRNAs encoding MYB family members with inferred function to regulate the conspicuous red fruit trait in var. bracteatus. MIR828 plesiomorphy (an ancient basal trait) may shed light on monocot apomorphic fruit development, postulated for 21 monocot families with fleshy fruits as due to homoplasy/convergence driven by tropical climate and/or enticements to vertebrate endozoic seed dispersers.
The paramedic profession: disruptive innovation and barriers to further progress
Authors: Newton Andy , Hunt Barry , Williams Julia
Published: April 2020

The paramedic profession in the UK evolved from a small number of pilot programmes in the early 1970s that focused on training selected NHS ambulance crews in advanced resuscitation techniques. Similar initiatives occurred almost simultaneously in the United States, Australia, New Zealand and Canada. This case study focuses primarily on the UK, and England in particular. The purpose of the initiatives described was to address the unmet needs of patients with serious injury and illness. Over the following decades, paramedics developed a clear identity and became fully professionally recognised and regulated as allied health professionals, becoming an example of the phenomenon termed ‘disruptive Innovation’; this is something that creates a new market and value network while disrupting existing ones. The steep developmental trajectory of paramedics has not been mirrored by a comparable pace of reform and modernisation in NHS ambulance services which, in comparison, have lagged behind and also failed to adapt to significant changes in the pattern, quantity and epidemiological characteristics of patient demand. This has led to a mismatch between the capabilities offered by paramedics and the professional opportunities available to them in ambulance services, and hampered these practitioners' ability to make full use of their skills. The consequence of this has often manifested as low levels of paramedic and other ambulance staff satisfaction, resulting in high rates of staff turnover. Parallel developments in medical personnel deployment have increased the quantity of medical labour available to patients with serious or life-threatening injuries, with medical staff added to helicopter emergency medical crews. While many patients with urgent conditions would have benefited from general practitioners being available out of hours, proportionally fewer doctors are available to fulfil this role today and those that are attracted to working with the ambulance service often prefer to respond to cases involving major injury. For these reasons and given the reality that the ambulance service is morphing into primarily an urgent care organisation, de-emphasising the transport aspect of the service, changes are needed to its model of operation and to staff management and support.
O TRABALHO DOCENTE E A SAÚDE DO PROFESSOR UNIVERSITÁRIO: UMA REVISÃO SISTEMÁTICA
Authors: Guimarães de Souza Neme Gláucia , Limongi Jean Ezequiel
Published: April 2020

Objetivo: o presente estudo teve como objetivo realizar uma revisão sistemática para avaliar a relação entre condições organizacionais de trabalho e queixas e/ou agravos à saúde em docentes do ensino superior. Métodos: Foram realizadas buscas em cinco bases de dados por meio das palavras-chave “professores universitários”, “riscos ocupacionais”, “saúde do trabalhador” e Brasil. Foram incluídos artigos originais de pesquisa, dissertações de mestrado e teses de doutorado, publicados no período compreendido entre 2000 e 2016 no idioma inglês e português. Resultados: a revisão identificou 162 estudos que abordavam a temática, dos quais 22 atenderam plenamente aos critérios estabelecidos. O estudo evidenciou diversos fatores do trabalho interferindo no estado de saúde dos docentes, desencadeando agravos, com destaque para alterações da saúde mental, mas também apontou realização pessoal no desenvolvimento das atividades laborais e qualidade de vida satisfatória. Conclusão: o adoecimento entre professores universitários ocorre, principalmente, devido à exaustão ocasionada pelo modo de produção do trabalho, que impõe uma sobrecarga de atividades, deixando-os em situação de vulnerabilidade.
Ecological Bio Energy Materials in Ukraine Current State and Prospects of Production Development
Authors: Sinchenko V. M. , Bondar V. S. , Gumentyk M. Ya. , Pastukh Yu. A.
Published: April 2020

The article presents the results of the analysis of the state of bioenergy in Ukraine in recent years, and notes a significant gap between its development indicators and those of other countries in the world. Measures for accelerated rates of biofuel production for the period up to 2025 and its projected indicators are substantiated. In particular, total biofuel production in Ukraine should increase from 2.83 million to 6.2 million tons, including: solid types up to - 3.5 million tons BOE, liquid-up to 0.7 million tons BOE, biogas-up to 2.0 million tons BOE. The list of main types of raw materials for biofuel production is given. The economic, technological, and economic characteristics of the main bioenergy crops, plantations of which are recommended to be laid in the coming years, are given. These performance indicators are obtained in production experiments, especially the ability to absorb carbon dioxide from the atmosphere and release oxygen, as well as reduce emissions of harmful substances during combustion. It is established that such a crop as Paulownia is the fastest growing plant (5-6 m per year). Another advantage of Paulownia is the high degree of environmental friendliness. One hectare consumes 1200 tons of CO2, significantly improving degraded, marginal land. The recommendations for the creation of industrial plantations of bioenergy crops and the material and technical base for processing are substantiated. Total costs for bioenergy by 2025 in the amount of $ 1,379 million have been determined. Proposal for co-operation of producers and processors of bio-raw materials at the local level is suggested.
Influence of Nanovulin-VRKh on cattle thermoregulation and chemical composition of milk
Authors: Gruntkoskyi M. S. , Kondtratiuk V. M. , Gryshchenko S. M. , Hryshchenko N. P. , Mytyay I. S.
Published: April 2020

The current research described the effect of neurotropic and metabolic non-hormonal biologically active medicine Nanovulin-VRKh © on the milk yield amount and the milk quality. Two cow groups were under study: the experimental and the control groups, each including four cows. The results showed that two of the neurotropic and metabolic Nanovulin-VRKh injections made 12 and 24 hours after the insemination did not effect the body thermoregulation of cows. Administration of the Nanovulin-VRKh contributes to stable fat formation in cow milk. Increased content of protein, nonfat milk solids, stable fat formation in milk were due to Nanovulin-VRKh administration. It was also established that, in the milk of experimental animals were administered the Nanovulin-VRKh, the pronounced effect of the drug on the protein, fat and nonfat milk solids content was observed, and the prolonged effect on these indices was reported during the fourth milking. Introduction of Cuprum aqua-chelate into the drug did not has toxic effect on the animal body and therefore would not effect the human health through the dairy products.
Didática nos anos iniciais do Ensino Fundamental: um estudo sobre a docência de 11 professoras
Authors: Almeida Rosineire Silva de , Cruz Giseli Barreto da
Published: April 2020

Este trabalho teve por objetivo analisar aspectos da docência de 11 professoras que são reconhecidas pelos seus pares como referência de prática docente porque ensinam na perspectiva de “fazer aprender alguma coisa a alguém” em contraposição à ideia de ensino como ato de “professar um saber” conforme distingue Roldão (2007). Teoricamente apoiou-se em Roldão, para abordar a dupla transitividade e a mediação no processo de ensino aprendizagem, e em Shulman, no que se refere à base de conhecimento profissional docente. Metodologicamente considerou a técnica da bola de neve, que utiliza cadeias de referências e entrevistas semiestruturadas. Onze professoras de escola pública localizadas no estado do Rio de Janeiro/BR participaram da pesquisa. A análise dos dados foi construída em três eixos: i- concepções de ensino; ii- saberes mobilizados pelas professoras para ensinar na perspectiva de “fazer aprender alguma coisa a alguém”; iii-  estratégias de ensino elaboradas pelas professoras. Os resultados indicam que: i-  as professoras concebem o ensino como ato investigativo; ii- o professor se apresenta como um pesquisador e criador de novas e variadas estratégias para ensinar; iii- o processo pedagógico de mediação do professor entre o conhecimento e o aluno envolve múltiplos saberes para suprir a necessidade da classe e dos alunos individualmente.
Notas marginais sobre Adorno e Freire
Authors: Habowski Adilson Cristiano , Conte Elaine
Published: April 2020

O ensaio científico discute a questão do exílio e das ideologias totalitários na vida de dois grandes intelectuais críticos, Theodor Adorno e Paulo Freire, que ao manifestarem suas posições de denúncia a explorações, às injustiças sociais e à rigidez do pensar da época, fadaram-se ao exílio. Nesse processo, compreende-se, com Adorno, que a educação passa pela reavaliação crítica da cultura e pela reeducação da sociedade administrada, coisificada, para superar o estado de opressão e alienação das questões que abordamos aqui. Por sua vez, Freire, parte de um cenário da comunicação como exigência para a recriação do conhecimento e da realidade sociocultural, seguindo as prerrogativas de autonomia, liberdade e dignidade humana imanente ao ato pedagógico. Concluímos que tais concepções, embora distintas, sinalizam para um movimento mais participativo da cultura e de resistência crítica ao pensamento homogeneizador, no sentido de despertar e promover o diálogo que revigora a experiência formativa e criativa da educação.
A Listening Lesson Prototype for the First-Grade in Primary School
Authors: Triwidayati Katarina Retno , Utami Tresiana Sari Diah
Published: April 2020

One of the main purposes of learning Bahasa Indonesia is to make students be fluent in using language. Language skills consist of two receptive skills (listening and reading), and two productive skills (speaking and writing). Those four skills are expected to be practiced equally. However, based on the previous research, listening lessons were rarely implemented in class. Moreover, listening lesson were inappropriately implemented by asking students to read. Additionally, the listening tests to measure the students’ listening proficiency were also unsuitable. Based on those findings, the researchers conducted a listening lesson developmental research for the first-grade primary school. This research is part of a developmental research referring to Gall, Gall, and Borg’s developmental research steps. This research is the second of five planned research phases. In this second phase, the researchers developed a listening lesson prototype validated by six validators. To validate the data, this research employed the triangulation method. Meanwhile, Miles and Huberman’s data analysis technique was utilized to analyze the data. The result of this research was a listening lesson prototype, including the mapping of basic competencies, networking of themes, determining of listening learning success indicators, learning stages, and listening evaluation.
Ayçiçek Yağı Tüketimine Etki Eden Faktörlerin Belirlenmesi; Çorum İli Örneği
Authors: KARAKAŞ Güngör
Published: April 2020

Ayçiçek yağının yenilebilir bitkisel yağlar içerisinde payı Türkiye’de yaklaşık olarak %70’tir. Bu çalışmanın amacı Çorum ilinde kişi başı ayçiçek yağı tüketim miktarını ve ayçiçek yağı tüketiminde etkili olan faktörleri belirlemektir. Bu amaca ulaşmak için Çorum ilinde 391 tüketici ile anket yapılmıştır. Kişi başı ayçiçek yağı tüketim miktarı ile değişkenler arasında anlamlı bir farklılık olup olmadığını belirlemek için ki kare analiz yöntemi kullanılmıştır. Araştırma sonuçlarına göre, yıllık kişi başı ayçiçek yağı tüketim miktarı ortalama 12.08 litre olarak hesaplanmıştır. Yapılan ki kare analizi sonucuna göre, ayçiçeği yağ tüketim miktarı ile cinsiyet, eğitim, markaya dikkat etme, fiyatı takip etme, hane halkı genişliği ve gelir arasında anlamlı bir fark bulunmuştur.
Presencia de larvas de Contracaecum sp. (Nematoda, Anisakidae) en el pez Astronotus ocellatus, destinado al consumo humano en Loreto, Perú
Authors: Serrano-Martínez Enrique , Tantalean Manuel , Quispe Marco , Casas Gina
Published: April 2020

En el mes de Febrero del 2008, se aislaron 6 larvas del nematodo Contracaecum sp. en 6 peces de la especie Astronotus ocellatus (nombre común: Acarahuazú), destinados al consumo humano, provenientes del río Ampiyacu, distrito de Pevas, Provincia Mariscal Ramón Castilla de la Región Loreto (Perú). Los nemátodos se encontraron enquistados en el mesenterio y una vez aislados se fijaron en alcohol al 70% para su traslado al Laboratorio de Parasitología de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Peruana Cayetano Heredia, donde se realizó su identificación. Este es el primer reporte de Contracaecum sp. en Astronotus ocellatus de la Amazonía Peruana.
Frecuencia de parásitos gastrointestinales en cuyes reproductoras de crianza intensiva
Authors: Huamán Meylin , Killerby Marjorie , Chauca Lilia
Published: April 2020

El objetivo del estudio fue determinar la frecuencia de parásitos gastrointestinales presentes en cuyes reproductoras de crianza intensiva, así como el grado de infección parasitaria. Se recolectó 250 muestras de intestino delgado, intestino grueso y ciego, los cuales se colocaron en frascos de boca ancha, identificados y transportados a 4°C. Las muestras fueron procesadas por las siguientes técnicas parasitológicas: directo, flotación y sedimentación. La identificación específica de parásitos en muestras positivas se realizó mediante un examen microscópico a través de características morfológicas de los huevos. Además, se determinó el grado de parasitismo de las infecciones. Del total de muestras analizadas el 37,2 ± 6,0% (93/250) resultaron positivos a parásitos gastrointestinales en reproductoras. Los parásitos identificados fueron Paraspidodera uncinata (20,4%), Eimeria caviae (12,0%), Capillaria sp. (4,8%), Balantidium sp. (4,4%), Trichuris sp. (2,0%), Passalurus sp. (0,4%) y Entamoeba sp. (0,4%). El 79,6% de las muestras positivas presentaron asociaciones monoparasitarias y el 20,4% biparasitarias. El parasitismo mixto más frecuente fue E. caviae y P. uncinata. El grado de infección fue leve (26.8%) para la mayoría de los animales positivos a P. uncinata, E. caviae, Capillaria sp, Balantidium sp, Trichuris sp, Passalurus sp y Entamoeba sp. Se concluye que P. uncinata y E. caviae son los parásitos más frecuentes encontrados en reproductoras de crianza intensiva. Se encontró asociación estadística entre el número de partos y el ambiente de crianza frente a la presentación de parasitosis.
Epidemiologic and Histopathologic Feature of Lung Cancer in Central Iran (2012-2018)
Authors: Khalilian Mohammad Sadegh , Narrei Sina , Hadian Mahdi , Zeinalian Mehrdad
Published: April 2020

Background: Lung cancer is one of the common causes of death worldwide. Although the incidence rate of lung cancer in Western countries is decreasing, it presents a growing trend in developed countries. Since there is no accurate enough information about the epidemiological and Histopathologic features of lung cancer in central Iran, Isfahan, we were motivated to conduct this research. Materials and Methods: This was a descriptive, cross-sectional study carried out in central Iran, Isfahan. All demographic, histopathological and clinical data of the lung cancer patients registered in MACSA, a referral charity-based cancer center in central Iran, was analyzed within 2012-2018 using SPSS v.22 software. Results: Altogether 260 patients with lung cancer were included in this study from 6127 cancer patients registered within 2012-2018 (4.2%). Out of them, 66.2% were men, and 18.8 % of the patients were alive at the time of the study. The mean age of the patients at diagnosis was 61.56 (SD=14.11, range: 9-93). Altogether, 63.1% of patients had metastasis of whom 57.6% were in stage IV at diagnosis. The Frequency of different types of lung cancer was 36.9% adenocarcinomas, 14.2% squamous cell carcinoma, 9.6% bronchogenic carcinoma and 8.1% small cell lung cancer, respectively. Altogether, 128 cases were smokers with an average 35.45 ± 14 pack- years. Only in 36.2% of the patients, the diagnostic and therapeutic biomarkers had been checked, and CK7 was positive in 88.9% of the cases in which the biomarker had been checked. Conclusion: Despite to similar Iranian studies, the most common histopathologic type of lung cancer among the patients was adenocarcinoma that it may be attributed to the lower consumption of smoking in our population and their different genetic context. Molecular biomarkers had been checked in a small portion of the patients. More education of the clinicians along with the development of cancer molecular testing may lead to promote the personalized-based approach.
Children are less affected by COVID-19: a family case study
Authors: Huang Di , Huang KeXin , Dai Yongya , Hu Rujun , Li Jin , Jiang DeYu , Shen Jian , Yan JiHong , Zhang Fang , Jiang Zhixia
Published: April 2020

Background: Family clustering has facilitated the transmission of SARS-CoV-2, and the outflows of people from Wuhan to their hometown has become the most important transmission channel in China. The study aimed to investigate the SARS-CoV-2 infection of an entire family, especially children. Methods: This family case study was conducted in General Mountain Hospital, Guizhou Province. In January 2020, we recruited a family of 13 members, including three children and nine adults, at different stages, from admission screening to discharge. We used standardized case report forms to collect clinical data between January 16, 2020 and March 1, 2020. These data included temperature, contact history, incubation period, laboratory test results, imaging results, length of hospital stay, and treatment outcomes. Results: Eight cases had confirmed diagnoses of SARS-CoV-2 infection, including three mild cases (37.5%) and five common cases (62.5%). The child patient had the shortest length of hospital stay and less obvious symptoms. There was no significant difference between the laboratory test results and CT scans. Conclusions: Children are not susceptible to virus infection in their families. Compared with adult patients, pediatric patients have milder symptoms, shorter hospital stays, and lower risk of lung infections. As this cannot confirm whether their nucleic acid amplification tests are negative or positive after discharge, the management and control of discharged patients should therefore be paid additional attention.
Pyridine and Benzoisothiazole Decorated Vanillin Chalcones: Synthesis, Antimicrobial, Antioxidant, Molecular Docking Study and ADMET Properties
Authors: Pathare Pintu , Tekale Sunil , Shaikh Rafique , Damale Manoj , Sangshetti Jaiprakash , Rajani Dhanaji , Pawar Rajendra
Published: April 2020

Background:

The search for new antimicrobial drugs is a never ending task due to microbial resistance to the existing drugs. Antioxidants are essential to prevent free radical reactions which lead to chronic diseases to human kind.

Objective:

The present studies were aimed to synthesis, characterization, antimicrobial and antioxidant activities of pyridine and benzoisothiazole decorated chalcones.

Materials and Methods:

FTIR spectra were recorded using KBr pellets on Shimadzu FT-IR spectrophotometer. 1H and 13C NMR spectra were recorded on Bruker 400 MHz spectrometer. Antimicrobial activity of the synthesized chalcones was found to be good against diffenet bacterial and fungal strains. Antioxidant activity was studied in terms of 2,2-diphenyl-1-picrylhydrazyl, hydroxyI and superoxide radical scavenging activities. Molecular docking was studied using Discovery Studio Visualizer Software, version 16 whereas Autodock Vina program was used to predict toxicity profile of the compounds using FAFDrugs2 predictor.

Results:

The compounds 5c, 5d & 6c showed good antioxidant activities. The insilico molecular docking study supports the experimental results and demonstrated that the chalcones 5d, 6a and 7a are the most active among the synthesized derivatives.

Conclusion:

Prediction of pharmacokinetic parameters and molecular docking studies suggest that the synthesized chalcones have good pharmacokinetic properties to act as lead molecules in the drug discovery process.
Fast and Accurate Hop-based Positioning based on Anchor-skeleton for Anisotropic Networks
Authors: Dou Rulin , Shi Weijuan
Published: April 2020

Background:

The hop-based positioning method is a straightforward, low-cost, and feasible
positioning method.

Methods:

Most previous hop-based algorithms assume that the network is isotropic and uniformly
distributed, which often does not reflect real-world conditions. In practice, the network may be anisotropic,
which makes the hop count between nodes may not match the real distance well.

Results:

As a result of this issue for hop-based positioning methods, in this paper, we propose a
novel scheme that builds a skeleton model between anchor nodes to represent the anisotropy of a
network. During the process of building the skeleton model, we use the corrected Akaike's Information
Criterion (AICc), which can assist in the construction of a reliable and high accuracy skeleton
model. With the help of the skeleton model with AICc, an unknown node can get a more accurate
and reliable estimated position.

Conclusion:

The results of both theoretical analysis and experimental simulation show that the optimal
hop-distance conversion model can be achieved, and compared to other similar algorithms,
the proposed algorithm can obtain the position estimation result in a fast and accurate manner.
Bacteria-based self-healing concrete: evaluation of full scale demonstrator projects
Authors: Mors Renée , Jonkers Henk M.
Published: April 2020

Bacteria-based self-healing concrete is an innovative concrete that contains a self-healing agent that provides the material with enhanced autonomous crack-sealing performance. A specific type of this concrete, based on a healing agent composed of bacterial spores and lactate as carbon source, has been developed and applied by the Delft University of Technology for over ten years. Under laboratory conditions it was proven that, depending on the dosage of healing agent, self-healing of cracks up to 0.8 mm widths occurs. As such the material potentially allows reduction of steel reinforcement used for crack width limitation in watertight constructions. Application of  self-healing concrete would therefore not only result in a reduction of costs but also in improvement of environmental performance (lower CO2 footprint) and ease of in situ casting due to reduction of use of steel in waterproof applications. However, according to the EN 1990 Eurocode (Basis of structural design), customary application of a novel type of concrete must be preceded by full scale demonstrators proving evidence for safe and functional performance. In this contribution we portray full scale application of bacteria-based self-healing agent as developed by the Delft research group in two repair mortar- and in two concrete construction demonstrator projects. These demonstrator projects show that addition of the bacteria-based self-healing agent to the concrete mix is safe as no negative side effects on construction performance was observed. However, it also proved difficult to find evidence for increased crack-healing performance as cracking in the demonstrator constructions hardly occurred. In further full scale demonstrators we therefore plan to drastically reduce amount of crack width-restraining reinforcement to show crack-healing capacity and potential to save on use of reinforcement steel in watertight concrete constructions.
Caracterización e incidencia de las bibliotecas escolares en el logro educativo en Tamaulipas
Authors: Domínguez Arteaga Rosa Amelia
Published: April 2020

El objetivo de esta investigación fue examinar las condiciones de las bibliotecas escolares y determinar el grado de correlación lineal entre éstas y el logro educativo en secundarias de Tamaulipas. Para ello se recurre al método estadístico descriptivo. En un primer momento se sistematiza la información disponible a fin de brindar un panorama general de la situación de las bibliotecas, así como el logro académico en el nivel abordado. Posteriormente, se calcula el coeficiente de correlación de Pearson entre las variables disponibilidad de bibliotecas por alumnos y la proporción de alumnos en el nivel IV del área de Lenguaje y Comunicación en secundarias de Tamaulipas del Plan Nacional para la Evaluación de los Aprendizajes (PLANEA). Por un lado, los resultados indican brechas significativas tanto en la distribución de las bibliotecas como en la proporción porcentual de alumnos en el nivel más alto de la prueba PLANEA entre municipios; por otro, se encontró que existe una relación principalmente negativa entre la disponibilidad de bibliotecas escolares y el logro educativo en las secundarias de los municipios de Tamaulipas.
Pelatihan Empati Untuk Meningkatkan Pemaafan Pada Mahasiswi Korban Kekerasan Dalam Hubungan Pacaran
Authors: Reza Faisal Adnan , Widyana Rahma
Published: April 2020

AbstractThis study aims to determine the effect of empathy training to improve forgiveness for female students who are victims of violence in dating relationships. Research subjects were 5 female students who were victims of violence in dating relationships. This study was only an experimental group, taken from the results of the pre-test on the empathy and forgiveness scale in the low and medium categories and interviews. The research design used was the experimental design of one group group pretest-posttest design. Data collection tools used in the form of empathy, forgiveness, observation and interviews. Analysis of the data used is the Wilcoxon Rank Test to see the difference in experimental group scores between before and after treatment. The Wilcoxon Rank Test found that there was a difference in the forgiveness score in the experimental group after giving empathy with a Z = -2.023 with a significance of 0.043 (p <0.05) with the mean pre-test (X test = 36.40) lower than the mean post-test (X ̅ = 63.40). The conclusion of this study is that there are differences in forgiveness scores between before and after being given empathy training.
Moderat Dan Puritan Dalam Islam: Telaah Metode Hermeneutika Khaled M. Abou El Fadl
Authors: Suhandary Dian
Published: April 2020

Umat Islam semestinya menjadi sarana perwujudan rahmat dan kasih sayang Tuhan bagi sesama makhluk. Sayangnya, pesan yang mengandung nilai-nilai humanis, toleran, dan demokrasi dibalik teks-teks suci tersebut telah dirampas oleh kelompok yang mengatasnamakan “wakil Tuhan”dibumi. Akibatnya, tindakan kesewenang-wenangan di balik nama agama masih menjadi persoalan. Abou El Fadl memetakan dua aliran besar di dalam Islam yaitu Puritanisme dan moderatisme. Penelitian ini akan mengetengahkan bagaimana pemikiran Hermeneutika Khaled M. Abou El Fadl terhadap aliran puritanisme dan moderatisme dalam Islam? Penelitian ini tergolong dalam penelitian pustaka, jalannya penelitian ini peneliti menggunakan metode deskriptif analisis. Hermeneutika Abou El-Fadl dapat disebut ‘hermeneutika negosiatif’. Menurutnya, makna harus merupakan hasil interaksi antara pengarang, teks, dan pembaca, di mana harus ada keseimbangan (balancing) dan proses negosiasi antara ketiga pihak, serta salah satu pihak tidak boleh mendominasi dalam proses penetapan makna. Selain itu, Abou El Fadl secara implisit mengandung semangat Gadamerian yang membaca teks secara subjektif, implikasinya seluruh interpretasi tidaklah bersifat final namun relatif.
Radicalism in Islam: The Politicization of The Mahdawiyah Hadith Among The Mahdi Movement
Authors: Muqtada Muhammad Rikza
Published: April 2020

Mahdism, or the belief in the resurrection of the eschatological figure of the Mahdi remains important in Islam today. This belief, legitimated by the mahdawiyyah hadith, has allowed many individuals throughout Islamic histories to claim themselves to be the Mahdi, as well as to carry out a radical strand of Islamic movement in order to support their claim. Using a historical method, this paper studies the history and development of mahdism, along with their interpretationof the mahdawiyah hadith; and analyzes the connection of such interpretation with the rise of religious radicalism. The study argues, mahdism is linked to the practices of millenarianism, formerly existed in Jewish and Christian theology. The emergence of mahdism related to the political conflict during the power transition from the Umayyad to the Abbasid dynasty. Yet, the rise of the Mahdi movement found its support from the mahdawiyyah Hadith, which are interpreted in such a way as to legitimize the radical-subversive movement of the mahdi’s leaders, enabling mahdism to develop, ideologically, as a radical movement. This study concludes that mahdism is at once a religious and political movement aiming to bring back the glory of Islam. Religion becomes a legitimate and effective ideological framework of a political mission.
Palabra, Tiempo y Concepto en el pensamiento de Hegel
Authors: Jiménez Redondo Manuel
Published: April 2020

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La hermenéutica analógica: Aportación fundamental de la filosofía mexicana
Authors: Álvarez Colín Luis
Published: April 2020

RESUMENEste artículo busca rehabilitar la analogía y el símbolo y articular los principales aspectos de una nueva hermenéutica que es una contribución significativa de la filosofía significativa de la filosofía mexicana. El fulcrum de este movimiento filosófico-que se analizará en el presente trabajo- consiste en: 1. integrar la metafísica y la ética con los aspecto de la historicidad, la cultura y la tradición; 2. resaltar las semejanzas y las diferencias, presentes en cada situación junto con el significado de los valores, los conflictor y el poder; y 3. realizar una nueva sínt4esis entre los universales y las características nativas de las subjetividades creando así una hermenéutica encarnada que tiene su suelo nutricio en el horizonte ontosemántico y trascendental del mundo vital.PALABRAS CLAVEANALOGÍA, SIMBOLO, ÍCONO, MUNDO VITALABTRACTL. Alavrez-Colin uses this article to explore both analogy and symbol, in mutual inclusion, instead of limitations of univocity and equivocality in order to articulate the main trends of a new hermeneutics, Analogic Hermeneutics, which is a core contribution of mexican philosophy. The fulcrum of this new philosophical movement consist of: 1. integrate the metaphysics and ethics with those aspects of historicality, culture and tradition; 2. enhance the similarities and the differences that are present in every situation (interpreted) with the significance of values, conflict and power; and 3. make a new synthesis between universald and indigenous characteristics of subjectivities creating in such a way an embodied hermeneutics, always grounded in the ontosemantic and trascendental horizon of lifeworld.KEYWORDSANALOGY, SYMBOL, ICON, LIFEWORLD
Los pitagóricos y la analogía. La visión de María Zambrano
Authors: Beuchot Mauricio
Published: April 2020

RESUMENEl artículo versa sobre un aspecto muy interesante y poco tratado de la filósofa española María Zambrano, que es su relación con el pensamiento órfico-pitágorico. Ella llega a definirse como órfico-pitágorica de alguna manera, pues da mucho importancia a la figura de Orfeo, que hizo un viaje a los infiernos, y que ella interpreta como algo que se debe hacer en la propia vida para poder salir de ese estado y ascender a uno más promisorio.PALABRAS CLAVEZAMBRANO-ANALOGÍA-ÓRFICOS-PITAGÓRICOSABSTRACTThe article deals with an important an neglected aspect of the spanish philosopher María Zambrano, which is her relation with the orfico-pytagorean thinking. She defines herself as an orfico-pytagorean in some extent, because she adscribes great importance to the figure of Orphaeus, who made a trip to the hells, and she interprets it as something to be done in our own life in order to get out of that inferior state and to ascent to a better in the line of spirit.KEYWORDSZAMBRANO-ANALOGY-ORPHICS-PITAGORICS
Hubungan Antara Kualitas Ibadah Shalat Dengan Keharmonisan Keluarga
Authors: Auliani Diah , Arini Aida
Published: April 2020

Praying is something that is done with special words and actions that begin with intention. prayer has the obligatory requirements of Islam, understanding, age, not being menstruated, not handicapped. The family is an institution that exists in the community, which can determine harmony in the community so that the community is very dependent on happiness in the family and harmony in the environment. The family is formed through a marriage. A harmonious family can determine the level of community welfare, because marriage is highly recommended by Islam for those who have been able and meet the conditions. The objectives of the researcher are (1) to describe the quality of prayer worship in Tebuireng Gg Village 1. (2) To describe the harmony of the family in Tebuireng Gg Village 1. (3) To describe the relationship between family harmony with the quality of prayer in Tebuireng Gg 1 village.The research that will be used is a descriptive quantitative expost facto approach that is correlative. The independent and related variables in this study include the Quality of Prayers (X) and Family Harmony (Y). This research was conducted in Tebuireng Gg 1 Hamlet in January-February 2019. The data collection used questionnaires and documentation distributed to each family. Date analysis techniques using hypothesis testing.
Sistem Pendidikan Inklusif Perspektif Neurosains
Authors: Novianti Ely
Published: April 2020

Assesing inclusion education in neuroscience perspectives is particularly interesting. This study is a literature review. Given the development of normal and special needs children have different backgrounds. Cognitive development of children are different according to parenting patterns. In this case the parents need to be aware of the type of child and need to understand in terms of neuroscience. Keep in mind education is the right of every child to gain knowledge and educate the individual. The background of every child is not an obstacle in getting a decent education. The government and education authorities now have acces to the concept of inclusive education. With the application of inclusive education can expand access to education for all groups including children with disabilities. This effort is made to develop the potential of intelligence, talent,and soft skills prossessed without discrimination.in addition, at the age of gold, children with special needs are directed to interest and talent. With experience early on hope when adolescents are able to hone and can compete with normal children. This is because there is already a maturity in the individualâ€™s ability and creativity.
Avaliação da Qualidade Ambiental do Parque da Jaqueira-Recife, Pernambuco (Evaluation of environmental quality Jaqueira park - Recife, Pernambuco)
Authors: Vilaça Matheus Davi , Souza Andrezza Araújo de , Silva Andrezza Karla de Oliveira , Pereira Eugênia Cristina
Published: April 2020

As áreas verdes influenciam nas condições climáticas e no bem estar social, melhorando a qualidade de vida da população e trazendo contribuições em âmbito ecológico. O escopo do trabalho foi avaliar a qualidade ambiental do Parque da Jaqueira – Recife, Pernambuco, a partir de um censo quantitativo das árvores, classificando-as por espécie e quanto à natureza, nativa ou exótica. Os resultados obtidos demonstram que o Parque possui uma rica diversidade de espécies arbóreas com 633 indivíduos, distribuídos em 49 espécies e 23 famílias botânicas. Dentre as espécies quantificadas 344 (54,34%) foram de origem nativa e 289 (45,65%) exótica. Com isso, concluímos que apesar de uma arborização satisfatória, o elevado número de espécies exóticas encontrados sugerem possíveis riscos de desequilíbrios ecológicos.    A B S T R A C T Urban Green areas has influence on climate conditions and social welfare, improving the quality of life of people and bringing contributions to ecological context. The objective was to make a quantitative census of the trees of the Park Jaqueira - Recife, Pernambuco, sorting by type and nature as native or exotic. The results obtained show that the park has a rich diversity of tree species with 633 individuals, including 49 species and 23 botanical families. Among the quantified species 344 (54,34%) were native and 289 exotic origin (45,65%). Under these circumstances, we conclude that despite a satisfactory afforestation, the high number of exotic species found suggest the potential for ecological imbalances. Key words: Green areas; Urban park; Tree inventory