bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multi-Criteria Decision Process for EV Charging Stations’ Deployment: Findings from Greece
Authors: Anthopoulos Leonidas , Kolovou Polytimi
Published: September 2021

Electro-mobility (EV) is an emerging transportation method, whose charging infrastructure development concerns a key-factor for its growth. EV charging infrastructure has not grown yet in Greece, regardless of the ambitious national targets that have been grounded for 2030 towards a climate-neutral mobility. This study introduces a multi-criteria decision-making (MCDM) framework for EV charging infrastructure deployment and operation, which respects both the economic and the technical aspects for public charging stations. The analytic hierarchy process (AHP) was followed for the MCDM framework’s definition, which used criteria that were in the corresponding literature and performed with interviews by experts from the EV growing market in Greece. The results show that the installation and operation of public EV charging stations, located in private spaces to ensure their protection against vandalism, within the urban areas is the preferred deployment approach. Moreover, this article tests a market model for the EV charging infrastructure ownership and operation. Findings show that the incentive for investment in EV charging infrastructure market in Greece, is driven by the direct investments of limited vendors, while it is not economically oriented, but it focuses on sustainability and environmental protection.
Study on Multiphysics Coupling and Automatic Neutronic Optimization for Solid Tritium Breeding Blanket of Fusion Reactor
Authors: Qu Shen , Cao Qixiang , Duan Xuru , Wang Xueren , Wang Xiaoyu
Published: September 2021

A tritium breeding blanket (TBB) is an essential component in a fusion reactor, which has functions of tritium breeding, energy generation and neutron shielding. Tritium breeding ratio (TBR) is a key parameter to evaluate whether the TBB could produce enough tritium to achieve tritium self-sufficiency (TBR > 1) for a fusion reactor. Current codes or software struggle to meet the requirements of high efficiency and high automation for neutronic optimization of the TBB. In this paper, the multiphysics coupling and automatic neutronic optimization method study for a solid breeder TBB is performed, and a corresponding code is developed. A typical module of China fusion engineering test reactor (CFETR) helium cooled ceramic breeder (HCCB) TBB was selected, and a 3D neutronics model of an initial scheme is developed. The automatic neutronic optimization was performed by using the developed code for verification. Results indicate that the TBR could increase from 1.219 to 1.282 (~5.17% improvement), and that the maximum temperature of each type of material in the optimized scheme is below the allowable temperature. It is of great scientific significance and engineering value to explore and study the algorithm for automatic neutronic optimization and the code development of the TBB.
Low-Pressure Turbine Cooling Systems
Authors: Marzec Krzysztof
Published: September 2021

Modern low-pressure turbine engines are equipped with casings impingement cooling systems. Those systems (called Active Clearance Control) are composed of an array of air nozzles, which are directed to strike turbine casing to absorb generated heat. As a result, the casing starts to shrink, reducing the radial gap between the sealing and rotating tip of the blade. Cooling air is delivered to the nozzles through distribution channels and collector boxes, which are connected to the main air supply duct. The application of low-pressure turbine cooling systems increases its efficiency and reduces engine fuel consumption.
Clinical Aspects of Adolescent Endometriosis
Authors: Nakamura Tomoko
Published: September 2021

Early diagnosis and long-term management of endometriosis is important in adolescent girls considering their potential for future pregnancy and need for preventing disease progression. However, symptoms and clinical findings of adolescent endometriosis may differ from those of typical adult endometriosis, making diagnosis difficult. In adolescents, menstrual pain may present as acyclic and unresponsive to commonly used medication. Typical imaging findings in adult endometriosis, such as ovarian endometriotic cysts and fibrotic scars, are less common in adolescents. Peritoneal lesions, characteristic of early-stage endometriosis, are commonly found in this age group. It should be noted that endometriosis may also be found in adolescents before menarche, because of premenarcheal endometriosis or congenital uterine anomaly and outflow obstruction; the latter requiring surgical correction. Although surgery is reported to be effective for pain, postsurgical recurrence rate is high, and the effect of hormonal treatment is controversial. The optimal timing for surgical intervention also remains to be determined. Here, we aim to identify the unique characteristics of endometriosis in adolescents to achieve early diagnosis and optimal management for this group of patients.
Urban Environmental Quality Assessment by Spectral Characteristics of Mulberry (Morus L.) Leaves
Authors: Dineva Snejana , Veleva-Doneva Petya , Zlatev Zlatin
Published: September 2021

In this paper, an analysis of the possibility of passive determination of the degree of environmental pollution based on data from the leaf blade of mulberry is made. With existing solutions in this area, the mulberry has been found to be under-researched. A disadvantage of the available solutions is that spectral indices are used, which is not a sufficient criterion for passively determining the degree of air pollution based on the surface characteristics of the mulberry leaves. Methods have been used to reduce the amount of data by latent variables and principal components. It has been found that a kernel variant of the principal components, combined with linear discriminant analysis, is an appropriate method for distinguishing the degree of air pollution from mulberry leaf data. The results obtained can be used to refine the approaches used to passively determine the degree of air pollution in the habitat area of the plant. Methods and software tools could be used to develop mobile applications and new approaches to remote sensing, in express determination of the degree of environmental pollution, according to data from the mulberry leaves.
Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users
Authors: Dawes Kelsey , Sampson Luke , Reimer Rachel , Miller Shelly , Philibert Robert , Andersen Allan
Published: September 2021

Alcohol and tobacco use are highly comorbid and exacerbate the associated morbidity and mortality of either substance alone. However, the relationship of alcohol consumption to the various forms of nicotine-containing products is not well understood. To improve this understanding, we examined the relationship of alcohol consumption to nicotine product use using self-report, cotinine, and two epigenetic biomarkers specific for smoking (cg05575921) and drinking (Alcohol T Scores (ATS)) in n = 424 subjects. Cigarette users had significantly higher ATS values than the other groups (p < 2.2 × 10−16). Using the objective biomarkers, the intensity of nicotine and alcohol consumption was correlated in both the cigarette and smokeless users (R = −0.66, p = 3.1 × 10−14; R2 = 0.61, p = 1.97 × 10−4). Building upon this idea, we used the objective nicotine biomarkers and age to build and test a Balanced Random Forest classification model for heavy alcohol consumption (ATS > 2.35). The model performed well with an AUC of 0.962, 89.3% sensitivity, and 85% specificity. We conclude that those who use non-combustible nicotine products drink significantly less than smokers, and cigarette and smokeless users drink more with heavier nicotine use. These findings further highlight the lack of informativeness of self-reported alcohol consumption and suggest given the public and private health burden of alcoholism, further research into whether using non-combustible nicotine products as a mode of treatment for dual users should be considered.
Agricultural Waste and Wastewater as Feedstock for Bioelectricity Generation Using Microbial Fuel Cells: Recent Advances
Authors: Pandit Soumya , Savla Nishit , Sonawane Jayesh M. , Sani Abubakar Muh’d , Gupta Piyush Kumar , Mathuriya Abhilasha Singh , Rai Ashutosh Kumar , Jadhav Dipak A. , Jung Sokhee P. , Prasad Ram
Published: September 2021

In recent years, there has been a significant accumulation of waste in the environment, and it is expected that this accumulation may increase in the years to come. Waste disposal has massive effects on the environment and can cause serious environmental problems. Thus, the development of a waste treatment system is of major importance. Agro-industrial wastewater and waste residues are mainly rich in organic substances, lignocellulose, hemicellulose, lignin, and they have a relatively high amount of energy. As a result, an effective agro-waste treatment system has several benefits, including energy recovery and waste stabilization. To reduce the impact of the consumption of fossil energy sources on our planet, the exploitation of renewable sources has been relaunched. All over the world, efforts have been made to recover energy from agricultural waste, considering global energy security as the final goal. To attain this objective, several technologies and recovery methods have been developed in recent years. The microbial fuel cell (MFC) is one of them. This review describes the power generation using various types of agro-industrial wastewaters and agricultural residues utilizing MFC. It also highlights the techno-economics and lifecycle assessment of MFC, its commercialization, along with challenges.
Addition of Active Dry Yeast Could Enhance Feed Intake and Rumen Bacterial Population While Reducing Protozoa and Methanogen Population in Beef Cattle
Authors: Phesatcha Kampanat , Chunwijitra Krittika , Phesatcha Burarat , Wanapat Metha , Cherdthong Anusorn
Published: September 2021

Urea–lime-treated rice straw fed to Thai native beef cattle was supplemented with dry yeast (DY) (Saccharomyces cerevisiae) to assess total feed intake, nutrient digestibility, rumen microorganisms, and methane (CH4) production. Sixteen Thai native beef cattle at 115 ± 10 kg live weight were divided into four groups that received DY supplementation at 0, 1, 2, and 3 g/hd/d using a randomized completely block design. All animals were fed concentrate mixture at 0.5% of body weight, with urea–lime-treated rice straw fed ad libitum. Supplementation with DY enhanced total feed intake and digestibility of neutral detergent fiber and acid detergent fiber (p < 0.05), but dry matter, organic matter and crude protein were similar among treatments (p > 0.05). Total volatile fatty acid (VFA) and propionic acid (C3) increased (p < 0.05) with 3 g/hd/d DY supplementation, while acetic acid (C2) and butyric acid (C4) decreased. Protozoal population and CH4 production in the rumen decreased as DY increased (p < 0.05). Populations of F. succinogenes and R. flavefaciens increased (p < 0.05), whereas methanogen population decreased with DY addition at 3 g/hd/d, while R. albus was stable (p > 0.05) throughout the treatments. Thus, addition of DY to cattle feed increased feed intake, rumen fermentation, and cellulolytic bacterial populations.
Photosensitive Yb-Doped Germanophosphosilicate Artificial Rayleigh Fibers as a Base of Random Lasers
Authors: Rybaltovsky Andrey , Popov Sergei , Lipatov Denis , Umnikov Andrey , Abramov Alexey , Morozov Oleg , Ryakhovskiy Dmitry , Voloshin Viktor , Kolosovskii Alexander , Vorob’ev Igor , Butov Oleg , Chamorovskiy Yuriy
Published: September 2021

Asingle-mode Yb-doped germanophosphosilicate fiber with ultra-low optical losses (less than 2 dB/km) was fabricated by means of the MCVD method utilizing an all-gas-phase deposition technique developed “in house”. The absorption and luminescent spectral properties of the fiber were thoroughly studied. The photosensitivity of the pristine (non-hydrogenated) fiber to 248 nm-laser radiation was confirmed by means of fiber Bragg grating (FBG) inscription directly during the drawing process. The random single-frequency lasing at the 1060-nm-wavelength obtained in the 21-m-long fiber with an array of weak FBG was reported. The developed laser slope efficiency in the backward-pumping scheme was measured as high as 32%.
Adding to Fire Fighter Safety by Including Real-Time Radar Data in Short-Range Forecasts of Thunderstorm-Induced Wind Shifts
Authors: Achtemeier Gary L. , Goodrick Scott L.
Published: September 2021

Abrupt changes in wind direction and speed caused by thunderstorm-generated gust fronts can, within a few seconds, transform slow-spreading low-intensity flanking fires into high-intensity head fires. Flame heights and spread rates can more than double. Fire mitigation strategies are challenged and the safety of fire crews is put at risk. We propose a class of numerical weather prediction models that incorporate real-time radar data and which can provide fire response units with images of accurate very short-range forecasts of gust front locations and intensities. Real-time weather radar data are coupled with a wind model that simulates density currents over complex terrain. Then two convective systems from formation and merger to gust front arrival at the location of a wildfire at Yarnell, Arizona, in 2013 are simulated. We present images of maps showing the progress of the gust fronts toward the fire. Such images can be transmitted to fire crews to assist decision-making. We conclude, therefore, that very short-range gust front prediction models that incorporate real-time radar data show promise as a means of predicting the critical weather information on gust front propagation for fire operations, and that such tools warrant further study.
Influence of Maternal Carbohydrate Source (Concentrate-Based vs. Forage-Based) on Growth Performance, Carcass Characteristics, and Meat Quality of Progeny
Authors: Gubbels Erin R. , Block Janna J. , Salverson Robin R. , Harty Adele A. , Rusche Warren C. , Wright Cody L. , Cammack Kristi M. , Smith Zachary K. , Grubbs J. Kyle , Underwood Keith R. , Legako Jerrad F. , Olson Kenneth C. , Blair Amanda D.
Published: September 2021

The objective of this research was to investigate the influence of maternal prepartum dietary carbohydrate source on growth performance, carcass characteristics, and meat quality of offspring. Angus-based cows were assigned to either a concentrate-based diet or forage-based diet during mid- and late-gestation. A subset of calves was selected for evaluation of progeny performance. Dry matter intake (DMI), body weight (BW), average daily gain (ADG), gain to feed (G:F), and ultrasound measurements (muscle depth, back fat thickness, and intramuscular fat) were assessed during the feeding period. Carcass measurements were recorded, and striploins were collected for Warner-Bratzler shear force (WBSF), trained sensory panel, crude fat determination and fatty acid profile. Maternal dietary treatment did not influence (p > 0.05) offspring BW, DMI, ultrasound measurements, percent moisture, crude fat, WBSF, or consumer sensory responses. The forage treatment tended to have decreased (p = 0.06) 12th rib backfat compared to the concentrate treatment and tended to have lower (p = 0.08) yield grades. The concentrate treatment had increased (p < 0.05) a* and b* values compared to the forage treatment. These data suggest variation in maternal diets applied in this study during mid- and late-gestation has limited influence on progeny performance.
Phenolic Composition and Antioxidant Properties of Cooked Rice Dyed with Sorghum-Leaf Bio-Colorants
Authors: Apea-Bah Franklin Brian , Li Xiang , Beta Trust
Published: September 2021

White rice is an important staple food globally. It is a rich source of energy but is low in dietary phenolic antioxidants. This current research aimed at providing scientific evidence for an alternative rice dish that has increased phenolic-antioxidant health-promoting potential by combining white rice with red cowpea beans and cooking with dye sorghum leaves hydrothermal extract, as a source of natural colorant. Boiled white rice and the rice–cowpea–sorghum extract dish were freeze-dried, and the free and bound phenolic compounds of raw and cooked samples were extracted. Phenolic composition, total phenolic content (TPC), and antioxidant activities (measured by 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity, Trolox equivalent antioxidant capacity, and oxygen radical absorbance capacity methods) of the raw and cooked samples were determined. Combining white rice with cowpea seeds and sorghum leaves extract significantly (p < 0.0001) increased the TPC and antioxidant activities of the rice due to the higher TPC and antioxidant activities of cowpea and sorghum leaves. Although boiling caused substantial losses of flavonoids and anthocyanins in the rice–cowpea–sorghum extract composite meal, the resulting dish had higher TPC and antioxidant activities than boiled white rice. Compositing white rice with phenolic-rich pulses can be an innovative approach to providing alternative healthy rice dishes to consumers.
Potential Relationship between the Changes in Circulating microRNAs and the Improvement in Glycaemic Control Induced by Grape Pomace Supplementation
Authors: Léniz Asier , Martínez-Maqueda Daniel , Fernández-Quintela Alfredo , Pérez-Jiménez Jara , Portillo María P.
Published: September 2021

MicroRNAs (miRNAs) represent important tools in medicine and nutrition as new biomarkers, and can act as mediators of nutritional and pharmacological interventions. The aim of the present study was to analyse the effect of grape pomace supplementation on the expression of seven selected miRNAs and their potential relationship with the observed positive effect on glycaemic control, in order to shed light on the mechanism underlying the beneficial effect of this dietary intervention. For this purpose, plasma samples were obtained from 49 subjects with metabolic syndrome. After supplementation with grape pomace (6 weeks), these subjects were categorised as responders (n = 23) or non-responders (n = 26) according to the changes in their fasting insulin rate. MiRNA expression at baseline and at the end of the supplementation was analysed by RT-PCR, and the MiRecords Database was used to identify potential target genes for the studied miRNAs. The increase observed in miR-23a in the whole cohort was present in both subgroups of participants. The increase in miR-181a was significant among non-responders but not responders. The decrease in miR-30c and miR-222 was found in the responders, but not in the non-responders. No changes were observed in miR-10a, miR-151a, miR-181a, and miR-let-7a expressions. After analysing these results, a potential involvement of the reduced expression of miR-30c and miR-222, two microRNAs associated with insulin resistance and diabetes, in the improvement of glycaemic control produced by grape pomace administration, can be proposed. Further research is needed to confirm the involvement of glycolytic enzymes, PI3K, AMPK, and IRS-1 in the effect of grape pomace, as suggested by the changes induced in microRNAs.
Probabilistic Day-Ahead Wholesale Price Forecast: A Case Study in Great Britain
Authors: Haben Stephen , Caudron Julien , Verma Jake
Published: September 2021

The energy sector is moving towards a low-carbon, decentralised, and smarter network. The increased uptake of distributed renewable energy and cheaper storage devices provide opportunities for new local energy markets. These local energy markets will require probabilistic price forecasting models to better describe the future price uncertainty. This article considers the application of probabilistic electricity price forecasting models to the wholesale market of Great Britain (GB) and compares them to better understand their capabilities and limits. One of the models that this paper considers is a recent novel X-model that predicts the full supply and demand curves from the bid-stack. The advantage of this model is that it better captures price spikes in the data. In this paper, we provide an adjustment to the model to handle data from GB. In addition to this, we then consider and compare two time-series approaches and a simple benchmark. We compare both point forecasts and probabilistic forecasts on real wholesale price data from GB and consider both point and probabilistic measures.
On the Origin and Evolution of the Intra-Cluster Light: A Brief Review of the Most Recent Developments
Authors: Contini Emanuele
Published: September 2021

Not all the light in galaxy groups and clusters comes from stars that are bound to galaxies. A significant fraction of it constitutes the so-called intracluster or diffuse light (ICL), a low surface brightness component of groups/clusters generally found in the surroundings of the brightest cluster galaxies and intermediate/massive satellites. In this review, I will describe the mechanisms responsible for its formation and evolution, considering the large contribution given to the topic in the last decades by both the theoretical and observational sides. Starting from the methods that are commonly used to isolate the ICL, I will address the remarkable problem given by its own definition, which still makes the comparisons among different studies not trivial, to conclude by giving an overview of the most recent works that take advantage of the ICL as a luminous tracer of the dark matter distribution in galaxy groups and clusters.
Polypeptide Composition and Topology Affect Hydrogelation of Star-Shaped Poly(L-lysine)-Based Amphiphilic Copolypeptides
Authors: Phan Thi Ha My , Huang Ching-Chia , Tsai Yi-Jen , Hu Jin-Jia , Jan Jeng-Shiung
Published: September 2021

In this research, we studied the effect of polypeptide composition and topology on the hydrogelation of star-shaped block copolypeptides based on hydrophilic, coil poly(L-lysine)20 (s-PLL20) tethered with a hydrophobic, sheet-like polypeptide segment, which is poly(L-phenylalanine) (PPhe), poly(L-leucine) (PLeu), poly(L-valine) (PVal) or poly(L-alanine) (PAla) with a degree of polymerization (DP) about 5. We found that the PPhe, PLeu, and PVal segments are good hydrogelators to promote hydrogelation. The hydrogelation and hydrogel mechanical properties depend on the arm number and hydrophobic polypeptide segment, which are dictated by the amphiphilic balance between polypeptide blocks and the hydrophobic interactions/hydrogen bonding exerted by the hydrophobic polypeptide segment. The star-shaped topology could facilitate their hydrogelation due to the branching chains serving as multiple interacting depots between hydrophobic polypeptide segments. The 6-armed diblock copolypeptides have better hydrogelation ability than 3-armed ones and s-PLL-b-PPhe exhibits better hydrogelation ability than s-PLL-b-PVal and s-PLL-b-PLeu due to the additional cation–π and π–π interactions. This study highlights that polypeptide composition and topology could be additional parameters to manipulate polypeptide hydrogelation.
In Vivo Evaluation of a Pectin-Honey Hydrogel Coating on Polypropylene Mesh in a Rat Model of Acute Hernia
Authors: Vercelli Cristina , Re Giovanni , Iussich Selina , Odore Rosangela , Morello Emanuela Maria , Gandini Marco , Giusto Gessica
Published: September 2021

Investigations about ventral hernia repair are focused on improving the quality, resistance, and biocompatibility of mesh. This study compared plain polypropylene mesh with a pectin-honey hydrogel-coated polypropylene mesh in an acute hernia model in rats. Forty Wistar rats, randomly assigned to two groups, were submitted to laparotomy, and a 1 cm × 2 cm fascial defect was created, centered on the midline. Uncoated (group C) or coated mesh (group T) was inserted in an inlay fashion to repair the defect. After 30 days, the rats were euthanized, and the presence of adhesions to the mesh was macroscopically evaluated. Histology and measurement of COX-2 as tissue inflammation markers were used to assess fascia tissue healing. Grades of adhesion were not different between groups. Histological score and COX-2 expression were not significantly different between groups, except for the higher inflammatory response demonstrated in group T. The pectin-hydrogel coated mesh could not reduce adhesion formation compared to uncoated polypropylene mesh but improved peritoneal regeneration and tissue healing.
Azai Dosi Kfaang (Modern or Families of Newness): Kom Families from Village to Coast and Further Diasporic Spaces
Authors: Nkwi Walter Gam
Published: September 2021

This paper focuses on “families of newness”, which amongst the Kom of Northwest Cameroon are known as azai dosi kfaang. It argues that because of geographical and social mobility experiences, families have not remained static, and consequently, the further they go from the village the more modernized they become. In recent times, African societies as well as family histories have been concerned with connecting with those who have been left behind. As a result, the blueprint that marks out the African family today is found in its mobility both within and out of the continent. At the same time, what glues the family together is the newer forms of technologies encapsulated in Information Communication Technologies (ICTs), which include amongst many others the cell phone, internet, WhatsApp, and Twitter. Letters pre-dated these new technologies and were significantly used by migrant families to stay “in touch”. Families began in the village, and as newer technologies were introduced—motor cars, a postal service and motorable roads—they moved or thought about places further away. With later technological developments, such as air travel and the mobile phone, families found themselves in distant diasporic spaces. This paper therefore hopes to make a contribution that relates family history and the history of migration to technology and social change. It also has the great value of discussing an area that gets too little attention in historiography. Fundamentally, the paper attempts to compare and contrast the use of technology, the news that could be shared (welfare, births, or obituaries), the length between contacts, the ability to make visits in person, the tensions that cropped up between family members abroad and those back at home in two periods, the 1930s–1940s and the 1990s to the present. What did these periods have in common? What was different and why? For the purpose of clarity, I will start the paper with a short introduction about the area, the issues of family formation, and kfaang. The second part of the paper will focus on the discussion of the “newness” of those who migrated to more modern places and the role of technology. The third part compares/contrasts the connections of families in the two periods (1930s–1940s and 1990s-present) in order to flesh out the argument.
Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution
Authors: Glenfield Cian , Innan Hideki
Published: September 2021

Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenesis and cancer evolution. In certain subsets of cancers duplicated and fused genes appear to be essential for initiation of tumour formation, and some even have the capability of transforming normal cells, highlighting the importance of understanding the events that result in their formation. The mechanisms that drive gene duplication and fusion are unregulated in cancer and they facilitate rapid evolution by selective forces akin to Darwinian survival of the fittest on a cellular level. In this review, we examine current knowledge of the landscape and prevalence of gene duplication and gene fusion in human cancers.
Beta vulgaris rubra L. (Beetroot) Peel Methanol Extract Reduces Oxidative Stress and Stimulates Cell Proliferation via Increasing VEGF Expression in H2O2 Induced Oxidative Stressed Human Umbilical Vein Endothelial Cells
Authors: Al-Harbi Laila Naif , Pandurangan Subash-Babu , Al-Dossari Alhanouf Mohammed , Shamlan Ghalia , Salamatullah Ahmad Mohammad , Alshatwi Ali A , Alotiby Amna Abdullah
Published: September 2021

The antioxidant capacity of polyphenols and flavonoids present in dietary agents aids in arresting the development of reactive oxygen species (ROS) and protecting endothelial smooth muscle cells from oxidative stress/induced necrosis. Beetroot (Beta vulgaris var. rubra L.; BVr) is a commonly consumed vegetable representing a rich source of antioxidants. Beetroot peel’s bioactive compounds and their role in human umbilical vein endothelial cells (HUVECs) are still under-researched. In the present study, beetroot peel methanol extract (BPME) was prepared, and its effect on the bio-efficacy, nuclear integrity, mitochondrial membrane potential and vascular cell growth, and immunoregulation-related gene expression levels in HUVECs with induced oxidative stress were analysed. Gas chromatography–mass spectroscopy (GC-MS) results confirmed that BPME contains 5-hydroxymethylfurfural (32.6%), methyl pyruvate (15.13%), furfural (9.98%), and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-Pyran-4-one (12.4%). BPME extract effectively enhanced cell proliferation and was confirmed by MTT assay; the nuclear integrity was confirmed by propidium iodide (PI) staining assay; the mitochondrial membrane potential (Δψm) was confirmed by JC-1 staining assay. Annexin V assay confirmed that BPME-treated HUVECs showed 99% viable cells, but only 39.8% viability was shown in HUVECs treated with H2O2 alone. In addition, BPME treatment of HUVECs for 48 h reduced mRNA expression of lipid peroxide (LPO) and increased NOS-3, Nrf-2, GSK-3β, GPX, endothelial nitric oxide synthase (eNOS) and vascular cell growth factor (VEGF) mRNA expression levels. We found that BPME treatment decreased proinflammatory (nuclear factor-κβ (F-κβ), tissue necrosis factor-α (TNF-α), toll-like receptor-4 (TLR-4), interleukin-1β (IL-1β)) and vascular inflammation (intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), EDN1, IL-1β)-related mRNA expressions. In conclusion, beetroot peel treatment effectively increased vascular smooth cell growth factors and microtubule development, whereas it decreased vascular inflammatory regulators. BPME may be beneficial for vascular smooth cell regeneration, tissue repair and anti-ageing potential.
Development and Validation of an Undiagnosed Diabetes Screening Tool: Based on the Korean National Health and Nutrition Examination Survey (2010–2016)
Authors: Cho Eunhee , Min Deulle , Lee Hye Sun
Published: September 2021

Approximately half of the population worldwide suffers from under/undiagnosed diabetes. In South Korea, 27.7% of people aged over 30 years have type 2 diabetes and are unaware of their condition because they have not been diagnosed. Optimal tools for identifying risk factors of undiagnosed diabetes, which is associated with multiple complications, are currently lacking. Secondary data analysis was conducted using the 2010–2016 Korean National Health and Nutrition Examination Survey. This study aimed to identify the risk factors in individuals not diagnosed with type 2 diabetes, using glycated hemoglobin as the diagnostic standard. Furthermore, we aimed to develop an accurate screening tool for diabetes using HbA1c values by analyzing the data of 12,843 adults (aged ≥20 years) not diagnosed with type 2 diabetes. Age, gender, family history of diabetes, hypertension diagnosis, waist-to-height ratio, smoking, and health check-ups were identified as significant risk factors for undiagnosed type 2 diabetes. A screening tool with total and cutoff scores of 13 and 7 points was developed, and it had a sensitivity of 82.7% and specificity of 58.2%. The developed screening tool appears to be a simple and cost-effective method for detecting undiagnosed type 2 diabetes.
The Socio-Demographic Characteristics Associated with Non-Communicable Diseases among the Adult Population of Dubai: Results from Dubai Household Survey 2019
Authors: Alnakhi Wafa K. , Mamdouh Heba , Hussain Hamid Y. , Ibrahim Gamal M. , Ahmad Amar Sabri , Ali Raghib , Abdulle Abdishakur
Published: September 2021

Background: Non-communicable diseases (NCDs) are the leading causes of death worldwide. In the UAE, NCDs account for nearly 77% of all deaths. There is limited empirical research on this topic in the UAE. We aimed to examine the association of non-communicable diseases and the sociodemographic characteristics among the adult population of Dubai. Methods: The study used secondary data from the Dubai Household Health Survey (DHHS), 2019. DHHS is a cross-sectional complex design, stratified by geographic area, and uses multistage probability sampling. In this survey, 2247 families were interviewed and only adults aged 18+ were included for the analysis. The quasi-binomial distribution was used to identify the socio-demographic characteristics association with NCDs. Results: The prevalence of NCDs among the adult population of Dubai was 15.01%. Individuals aged 60+, local Arabs (Emirati), divorced and widowed individuals, and individuals who were not currently working reported NCDs more than the other groups. In the regression analysis, the association with NCDs were reported among elderly people, males, unmarried individuals, older individuals who are unmarried, and Emiratis. Conclusion: The study identified several socio-demographic characteristics associated with reporting NCDs. This is one of the few studies related to NCDs in Dubai. Allocating appropriate resources to the population groups identified is crucial to reduce the incidence of NCDs in the Emirate.
Analysis of Earlier Temporomandibular Joint Disorders in JIA Patients: A Clinical Report
Authors: Polizzi Alessandro , Quinzi Vincenzo , Santonocito Simona , Palazzo Giuseppe , Marzo Giuseppe , Isola Gaetano
Published: September 2021

The aim of this study was to analyse the structural characteristics of the temporo-mandibular joint (TMJ) and the dysfunctional consequences induced by disease in subjects with juvenile idiopathic arthritis (JIA). The study was conducted in 25 patients with JIA (median age (IQR), 13.9 (10.9–15.3)) and 26 healthy controls (median age (IQR), 14.3 (11.6–17.2)) years. All enrolled patients were subjected to anamnestic evaluation, laboratory parameters, JIA subclass, and type of therapy for the disease. A clinical-gnathological evaluation, anamnestic and dysfunctional index (Ai and Di), and magnetic resonance imaging of TMJs were performed in all patients. The test group showed a significant reduction (p < 0.001) regarding the clinical findings such as maximal mouth opening, left and rightward laterotrusion and protrusion, and a significant difference in the reported symptoms (TMJ sounds, reduced mouth opening and pain), and Ai and Di (p < 0.001) compared to healthy patients. Correlation analysis showed a significant correlation between the median duration of disease and the maximum mouth opening and between visual analogue scale (VAS) score and maximum mouth opening, leftward laterotrusion, rightward laterotrusion, and protrusion. The results obtained in this study suggest that patients with JIA presented a cohort of symptoms in TMJs in comparison with healthy controls. Moreover, a careful TMJs evaluation and an early diagnosis of TMJs dysfunction and regular follow-ups are recommended in order to prevent and reduce functional and chewing problems in patients with JIA.
Lessons Learned from Developing Digital Teaching Modules for Medical Student Education in Neurosurgery during the COVID-19 Pandemic
Authors: Rupa Rosita , Pojskic Mirza , Nimsky Christopher , Voellger Benjamin
Published: September 2021

Background: The coronavirus 2019 (COVID-19) pandemic forced students and teachers to rapidly adopt digital education methods. Proper guidance for and refinement of such methods is continuously required. Here, we report on the educational experience students and academic staff at the neurosurgical department of a German university hospital made with digital teaching modules (DTMs) that were newly developed due to the transition to digital teaching during the first year of the COVID-19 pandemic and on the insights gained therefrom. Methods: Nine newly created DTMs provided students the option to anonymously evaluate each module by assigning a score from 0 (worst value) to 5 (best value) to it. Access count, evaluation count, average evaluation, number of included (interactive) figures, number of presented cases, number of linked publications, and number of included multiple-choice questions for each DTM were recorded retrospectively. For each DTM, we aimed to correlate access count, evaluation count, and average evaluation with the number of included (interactive) figures, number of presented cases, number of linked publications, and number of included multiple-choice questions. E-mail responses from individual students as to the DTMs were collected. Among students, an anonymous, voluntary online survey regarding the DTMs was conducted. Results: Number of figures and average evaluation per DTM were significantly positively correlated (Spearman’s rho = 0.85; p = 0.0037). Number of figures and number of evaluations per DTM were also significantly positively correlated (Spearman’s rho = 0.78; p = 0.0137). Responses from individual students indicated that illustrative cases and interactive figures might further increase DTM popularity. Conclusion: As a valuable adjunct in medical student education, DTMs should contain (interactive) figures, illustrative cases, a scoring option, and the option to give individual feedback towards the academic staff.
Smart Architectural and Urban Heritage: An Applied Reflection
Authors: Brusaporci Stefano , Maiezza Pamela
Published: September 2021

The aim of this paper is to present the use of 3D models and augmented reality (AR) to study and communicate architectural and urban values and, therefore, favor the development of dedicated forms of “smart heritage”. The study rises from a reflection on the concept of “heritage”, as defined in the international documents, intended as an evolving idea that puts together tangible and intangible aspects. Moreover, digital technologies favor “phygital” applications where the digital dimension support the traditional ones. In this way, AR allows the superimposition of multimedia information to heritage, respecting the historical matter of the artefacts, and supporting a “smart heritage” application. In particular, mobile AR, with real-time and ubiquitous visualizations, offers the opportunity to show past urban and architectural configurations to investigate and describe the transformations that have led to the current configuration, and consequently highlighting the present historical and architectural values of the buildings. Two case studies are presented: the square of St. Basilio Monastery, with its historical transformations, and the Basilica of Collemaggio, a pivotal building in the rites of “Perdonanza Celestiniana”.
QSL: Subliminal Messaging by the Nuclear Industry in Germany during the 1980s
Authors: Spennemann Dirk H. R.
Published: September 2021

During the late 1970s and early 1980s, the German nuclear power industry came under considerable socio-political pressure from the growing environmental and anti-nuclear movement. As part of a diversified public relations strategy, the Kraftwerk Union (KWU, later Siemens) as the main manufacturer of nuclear power plants distributed pre-printed QSL cards to amateur radio enthusiasts. These cards carried images of the latest nuclear power plants built by KWU. This paper examines the history, iconography and distribution of these QSL cards in the context of the heritage of the German nuclear power industry. It is the first study of its kind to examine the heritage significance of QSL cards.
Different Models, Different Outcomes? A Comparison of Approaches to Land Use Modeling in the Dutch Limes
Authors: Verhagen Philip , de Kleijn Maurice , Joyce Jamie
Published: September 2021

Current advances in spatial simulation bring unprecedented possibilities for spatio-temporal modeling. In this paper, we focus on modeling the impact of settlement on land use in the Roman period in the Dutch river area, on the northern frontier of the Roman Empire. During this period, the area witnessed a strong population increase that put more demands on the available land to produce food, not only for the local population, but also for the soldiers stationed on the frontier and the citizens of the newly founded towns. We compare an agent-based model (ABM) of agricultural production in the region (ROMFARMS), and a model using the Past Land Use Scanner (PLUS. Both were used to estimate the effects of increased agricultural demand through simulations of food production, taking into account the available workforce and the productivity and availability of suitable land. However, how should we evaluate the model outcomes? What are the advantages and limitations of each? We discuss issues of scale, temporal resolution and model inputs, together with questions of technical implementation and validation. In this way, we aim to point the way to future researchers to implement these approaches effectively in other contexts.
Predictors of Occupational Burnout: A Systematic Review
Authors: Shoman Yara , El May Emna , Marca Sandy , Wild Pascal , Bianchi Renzo , Bugge Merete , Caglayan Cigdem , Cheptea Dimitru , Gnesi Marco , Godderis Lode , Kiran Sibel , McElvenny Damien , Mediouni Zakia , Mehlum Ingrid , Mijakoski Dragan , Minov Jordan , van der Molen Henk , Nena Evangelia , Otelea Marina , Guseva Canu Irina
Published: September 2021

We aimed to review occupational burnout predictors, considering their type, effect size and role (protective versus harmful), and the overall evidence of their importance. MEDLINE, PsycINFO, and Embase were searched from January 1990 to August 2018 for longitudinal studies examining any predictor of occupational burnout among workers. We arranged predictors in four families and 13 subfamilies of homogenous constructs. The plots of z-scores per predictor type enabled graphical discrimination of the effects. The vote-counting and binomial test enabled discrimination of the effect direction. The size of the effect was estimated using Cohen’s formula. The risk of bias and the overall evidence were assessed using the MEVORECH and GRADE methods, respectively. Eighty-five studies examining 261 predictors were included. We found a moderate quality of evidence for the harmful effects of the job demands subfamily (six predictors), and negative job attitudes, with effect sizes from small to medium. We also found a moderate quality of evidence for the protective effect of adaptive coping (small effect sizes) and leisure (small to medium effect sizes). Preventive interventions for occupational burnout might benefit from intervening on the established predictors regarding reducing job demands and negative job attitudes and promoting adaptive coping and leisure.
Drug Use Control Perception and Strategies in General and Clinical Population in a Spanish City
Authors: Amigó Salvador , Beleña Angela
Published: September 2021

Background: This article evaluates the perception of drug use control and strategies in Valencia City (Spain) in a general and clinical population, in two independent studies. Material and Methods: 1071 people participated. In Study 1 (n = 924) the entire sample came from the general population (GP), and in Study 2 (n = 147), 68 were drug users being treated in an Addictive Behavior Unit (ABU), and 79 people of the GP. The drug use control perception and strategies in both subgroups were compared. The participants filled in the Drug Use Strategies Scale and a Drug Use Survey. Results: A high level of perception of drug control in the GP was obtained (72.7% in Study 1 and 67.5% in Study 2), and 32.5% in the ABU subgroup. People in the GP and drug users in treatment differ in some control strategies. A predictive profile of the perception of control was obtained for Study 2. Conclusion: The high degree of perception of controlling drug use in the GP, and partially in drug users being treated, and the specific control strategies reported suggests that moderate use and drug control strategies are a great value alternative to bear in mind compared to abstinence.
Determining Validity of Critical Power Estimated Using a Three-Minute All-Out Test in Hot Environments
Authors: Kuo Yu-Hsuan , Cheng Ching-Feng , Kuo Yu-Chi
Published: September 2021

The aim of this study was to investigate the effects of heat on the validity of end-test power (EP) derived from a 3-min all-out test (3MT), which is considered as an alternative method for determining the conventional critical power. Twelve male cyclists were required to perform incremental exercise tests (IET) and 3MTs in both high temperature (HT; 35 °C) and thermoneutral temperature (NT; 22 °C) environments. Maximal oxygen uptake (VO2max), and first and second ventilatory thresholds (VT1 and VT2, respectively) against the power output (wVO2max, wVT1, and wVT2) were measured during IETs. EP was recorded during the 3MTs. A significant correlation was observed between wVT2 and EP under NT (r = 0.674, p < 0.05) and under HT (r = 0.672, p < 0.05). However, wVO2max, wVT1, wVT2, and EP were significantly higher in NT than in HT (p < 0.05). In conclusion, although the physiological stress induced by HT might impair exercise performance, the EP derived from 3MT can validly estimate wVT2 under HT conditions.
The Impact of COVID-19 Outbreak on Syncope Units Activities in Italy: A Report from the Italian Multidisciplinary Working Group on Syncope (GIMSI)
Authors: Russo Vincenzo , Boggian Giulio , Bolognesi Maria Giulia , Carretta Domenico Maria , Cencetti Simone , De Laura Domenica , Hrovatin Enzo , Pastori Paolo , Tomaselli Caterina , Parente Erika , Rafanelli Martina , Ungar Andrea ,   on behalf of COVID-19 GIMSI Study Group
Published: September 2021

The aim of our study was to evaluate the impact of the COVID-19 outbreak on Syncope Units (SUs) Activities in Italy. Methods: Data about types of SU activities and admissions were obtained from 10 SUs throughout Italy, certified by the Italian Multidisciplinary Working Group on Syncope (GIMSI), from 10 March 2020 to 31 December 2020 and compared with the same time frame in 2019. Results: A remarkable reduction in overall non-invasive diagnostic tests (−67%; p < 0.001) and cardiac invasive procedure. Elective cardiac pacing procedures disclosed a significant decrease (−62.7%; p < 0.001); conversely, the decrease of urgent procedures was not significant (−50%; p = 0.08). There was a significantly increased rate of patients who underwent both telemedicine follow-up visits (+225%, p < 0.001) and cardiac implantable electronic devices (CIEDs) remote monitoring follow-up visits (+100%; p < 0.001). Conclusion: The COVID-19 outbreak was associated with a remarkable decrease in all clinical activities of Syncope Units in Italy, including both non-invasive tests and cardiac invasive procedures; conversely, a significant increase in telehealth activities was shown.