bluuebunny/crossref_metadata_2025 huggingface dataset:
VITAMIN A CONTENT AND HEDONIC TEST OF MODIFIED MODISCO SLURP PUDDING WITH VARIOUS CARROT EXTRACT ADDITIONS
Authors: Videricka Eryka Maryta , Ningtyias Farida Wahyu , Rohmawati Ninna
Published: March 2024

Backgorund : A Modisco is a form of PMT-P as a treatment for malnutrition and severe malnutrition. To increase the acceptance and function of nutritional sources, Modisco is done by modifying its shape and composition to become Modisco slurp pudding with the addition of carrot juice.
Objectives : The purpose of this study was to analyze the content of Vitamin A and the results of the favorite test of the modisco suction pudding with the addition of carrot juice variations of 0%, 5%, 10%, and 15%.
Method : This study used an experimental research method in the form of a Posttest Only Control Group Design design. The design of this study used two groups, namely the treated group, namely the modisco suction pudding with the addition of various carrot extracts and the untreated group, the modisco suction pudding without the addition of carrot juice.
Results : The results of the statistical test of Vitamin A levels using One-Way ANOVA showed a significance value of 0.0001 (<0.05) or there was a significant difference in Vitamin A levels in the modisco suction pudding with variations in the addition of carrot juice.
Conclusion : The statistical results of the preference test show that only the aroma and taste are significantly different, while the color and texture are not significant. Sample X0 has a preferred aroma and taste compared to X1, X2, and X3. Based on the Vitamin A content test and the Preferred Test X1, the value of Vitamin A content was closest to the nutritional requirement of toddlers for Vitamin A and was the most preferred treatment group.
ANALYSIS OF VITAMIN D LEVELS & COMPLETENESS OF COVID-19 VACCINE WITH RECURRENT COVID-19 INFECTIONS
Authors: Nurjanah Siti , Hermawan Dessy , Aryastuti Nurul , Muhani Nova , Furqoni Prima Dian , Sary Lolita , Widodo Slamet
Published: March 2024

Latar Belakang: Pandemi covid-19 mulai tampak terkendali, namun korban jiwa masih terus bertambah. Data dari Satuan Tugas Penanganan Covid-19 Nasional, hingga September 2022 ini, di Indonesia telah lebih 150 ribu jiwa orang meninggal akibat penyakit ini. Akhir-akhir ini, ada penelitian yang melaporkan bahwa terdapat hubungan antara kadar vitamin D di dalam darah dengan sistem imunitas.
Tujuan: adalah untuk menganalisis hubungan antara kadar vitamin D dalam darah dengan terjadinya infeksi covid-19 berulang.
Metode: Penelitian ini adalah penelitian survey analitik dengan pendekatan cross sectinal yang mencoba mengkaji hubungan antara kadar vitamin D darah, status kelengkapan vaksin, kepatuhan akan protocol kesehatan, usia dan jenis kelamin dengan terjadinya infeksi covid-19 berulang. Populasi dalam penelitian ini adalah seluruh dosen di Universitas Malahayati (Unmal) Bandar Lampung yang bersedia secara sukarela menjadi subyek penelitian ini yang berjumlah 62 orang. Adapun teknik sampling yang digunakan adalah non probability sampling: consecutive sampling, dengan kriteria inklusinya adalah yang pernah terinfeksi covid-19 pada tahun 2022 ini, sehingga didapatkan 47 orang sampel yang mememenuhi kriteria tersebut. Data yang terkumpul dianalisis dengan menggunakan regresi logistik.
Hasil: Hasil penelitian didapatkan bahwa ada hubungan yang signifikan antara status kelengkapan vaksin covid-19 (p-value: 0,001) dengan OR 8,24 dan kadar vitamin D dalam darah (p-value: 0,007) dengan nilai OR 8,47.
Kesimpulan: Semakin tidak lengkap vaksin covid-19 nya dan semakin rendah kadar vitamin D dalam darah, maka akan semakin besar potensi untuk mengalami infeksi covid-19 berulang.
Hubungan antara Asupan Zat Gizi dan Pertumbuhan Tinggi Badan pada Atlet Remaja di Indonesia: A Cross Sectional Study
Authors: Penggalih Mirza Hapsari Sakti Titis , Isnanta Raden , Rahadian Bayu , Margono Margono , Sujadi Dadi , Wicaksari Sifa Aulia , Reswati Vigur Dinda Yulia , Indriyani Sinta , Niamilah Ibtidau
Published: March 2024

Latar Belakang: Usia remaja merupakan usia efektif dalam perkembangan anatomi, fisiologis, dan metabolisme, dimana pemenuhan asupan gizi khususnya atlet, menunjang aktivitas fisik, pertumbuhan, perkembangan, pemulihan, dan performa. Namun, sering dijumpai asupan gizi atlet tidak adekuat yang berisiko pertumbuhan tidak optimal dan performa atlet tidak maksimal.
Tujuan: Penelitian ini diharapkan memberikan dampak penguatan stakeholder olahraga untuk lebih memperhatikan asupan dan pertumbuhan tinggi badan atlet di Indonesia dengan menganalisis hubungan asupan zat gizi dan pertumbuhan tinggi badan atlet.
Metode: Penelitian ini merupakan penelitian potong lintang di SKO Kemenpora Cibubur, PPLP Jawa Barat, PPLP Yogyakarta, PPLP Nusa Tenggara Barat, dan PPLP Sulawesi Selatan dengan subyek penelitian sebanyak 330 atlet dengan pemelihan subyek menggunakan metode purposive sampling berdasarkan kriteria inklusi dan eksklusi.
Hasil: Median usia subyek adalah 16 tahun dengan partisipasi didominasi oleh atlet strength (66,1%) dibandingkan endurance. Median tinggi badan sebesar 165 cm dan z-score TB/U dan IMT/U masing-masing -0,43 SD and 0,11 SD. Hubungan signifikan antara asupan energi, protein, lemak, dan karbohidrat dengan tinggi badan atlet (p<0,05), dan asupan energi, lemak dan karbohidrat dengan z-score TB/U. Sedangkan, asupan energi, protein, lemak dan karbohidrat tidak berhubungan signifikan dengan z-score IMT/U. Disisi lain, asupan kalsium dan vitamin D dengan tinggi badan (cm), z-score TB/U maupun IMT/U tidak menunjukkan hasil hubungan yang signifikan.
Kesimpulan: Asupan energi, protein, lemak, dan karbohidrat berhubungan secara signifikan dengan tinggi badan atlet, sedangkan asupan kalsium dan vitamin D tidak berhubungan secara signifikan. Pemenuhan asupan gizi atlet terutama cabang olahraga yang memperhatikan tinggi badan perlu diperhatikan dalam menunjang performa atlet.
Factors Affecting Abdominal Circumference in Adolescent Girls
Authors: Luthfiya Lulu' , Pibriyanti Kartika , Nabawiyah Hafidhotun , Fathimah Fathimah , Ummah Safira Kholifatul
Published: March 2024

Background: Central obesity was a health problem in Indonesia. One of indicator to find out central obesity was abdominal circumference. According to preliminary research, 28.4% of students had abdominal circumference >80 cm. Central obesity cause is multifactorial.
Objectives: To identify factors related to abdominal circumference in adolescent girls.
Methods: The design research was a cross-sectional. The total sample was 89 respondents, using the Lemeshow formula. The Sampling was taken by purposive sampling. The abdominal circumference data was measured by a metline. The percentage of body fat was analyzed with the Omron body fat analyzer. Food consumption patterns used Semi Quantitative Food Frequency (SQ-FFQ). Emotional overeating used the Adult Eating Behaviour Questionnaire (AEBQ), diet attitude, and oral control with the Eating Attitude Test (EAT)-26. The Data was analyzed by STATA 13 with the spearman test.
Results: Relationship of BMI (p=0.000; r=0.677), percentage of body fat (p=0.000; r=0.56), kind of junk food (p=0.02; r=0.23). frequency of junk food (p=0.04; r=0.21), energy intake from junk food (p=0.0061, r=0.28), fat intake from junk food (p=0.018, r=0.24), total enery intake (p=0.036; r=0.222), total fat intake (p=0.01; r=0.24); total fiber (p=0.17; r=0.14); overeating (p=0.018, r=0.25); diet attitude (p=0.000; r=-0.52), and oral control (p=0.0001; r=0.39) with abdominal circumference.
Conclusions: There was a relationship between BMI, body fat percentage, junk food consumption pattern (type, frequency, amount of intake and fat), energy intake, fat intake, emotional overeating, diet attitude, and oral control of the abdominal circumference. There was no significant relationship between fiber intake and abdominal circumference.
Factor Analysis of Stunting Toddler Feeding Patterns using Transcultural Nursing Approach
Authors: Maulina Rifzul , Retnaningsih Reny , Safitri Rani , Amalia Waifti
Published: March 2024

Background: In 2022, prevalence of stunting in Indonesia reach 21.6%. The direct causes of stunting was nutritional intake. The problem of nutritional intake was related to the cultural practices of Indonesian, so this research used a transcultural nursing.
Objectives: This study aimed to identify factors influencing feeding patterns in stunting children based on transcultural nursing.
Methods: Cluster sampling was used for this cross-sectional with 145 mother-child pairs. The independent variables were maternal education, economics, regulations and policies, cultural values and lifestyle, social and family support, religiosity and philosophy and technology. The dependent variable was feeding pattern. The instrument used was a questionnaire. Spearman Rho (p-value=0.05) was used to analyze the relationship between variables.
Results: Economic factors (p=0.031; r=0.250), government policies and norms (p=0.034; r=0.180), cultural and lifestyle values (p=0.001; r=0.540), social support and family (p=0.000; r=0.270), religious and philosophical beliefs (p=0.000; r=0.321), and technological developments (p=0.002; r=0.210) were associated with feeding pattern, no correlation between feeding pattern and mother’s education (p=0.689).
Conclusions: Economy, regulation and policy, cultural value and lifestyle, religiosity and philosophy, social support and family, and technology associated stunting child's feeding pattern. Cultural beliefs and lifestyle were the most important factors for stunting children's feeding patterns so it is envisaged that paramedics continue to expand their preventive and persuasive efforts by providing health consultations to moms and families.
Impact of Self-Management on the Quality of Life of Patient with Diabetes Mellitus: A Systematic Review
Authors: Sukma Wicaturatmashudi  , Pradana Soewondo  , Debie Dahlia  , Sali Rahadi Asih  , Dewi Gayatri  , Ratna Aryani
Published: March 2024

Background: Diabetes mellitus is a hereditary and degenerative disease that requires management throughout the patient's life to maintain blood sugar stability and psychosocial factors. Aims: This systematic review aims to determine the effect of self-management on the quality of life of patients with Type 2 DM. Methods: The selection of the studies refers to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines and JBI's checklist was used to assess the quality of the study. The study selection came from 7 databases Scopus, ScienceDirect, Sage Journals, ProQuest, Emerald Insight, Pubmed dan Taylor & Francis. The number of studies included in the review was 7 articles, 5 articles used an RCT design, and 2 articles were quasi-experimental. Results: The finding showed 2 articles that provide interventions in the form of DSME, 1 article emphasizes self-management interventions based on self-efficacy theory that is oriented towards active family involvement, 1 article specifies interprofessional-based DSM through telemonitoring media, 1 article focuses on community-based self-management interventions, and 1 article specializes in the use of weblogs in conducting self-management. Special 2 articles emphasize nurse leadership in managing interventions during the study. Five articles showed a significant effect of self-management on quality of life and 2 articles had no effect. Conclusion: The findings can be used to optimize self-management intervention in DM patients to improve their quality of life.
Formulation and Analysis of Handwritten Batik Wax Quality from Recycled Materials
Authors: Rahmad Dodi , Herliansyah Muhammad Kusumawan , Sudiarso Andi , Haerudin Agus
Published: March 2024

Used cooking oil can be utilized as an alternative raw material for making batik wax. Recycling batik wax involves using recycled materials such as used wax, used cooking oil, and other substances like paraffin, microwax, colophonium resin, and damar resin. The recycling of used wax and the utilization of used cooking oil are crucial for the batik industry as they reduce production costs and environmental pollution. A combination of Taguchi and Grey Relational Analysis (GRA) method is employed to obtain optimal values for the response characteristics of line width continuity and permeability of wax. Recycled and new wax is applied to mori fabric and compared based on batik quality criteria. The research results indicate that the optimal composition for recycled wax consists of 510 grams of used wax (41.5%), 36 grams of used cooking oil (2.9%), 102 grams of paraffin (9.8%), 84 grams of microwax (6.8%), 300 grams of colophonium resin (24.4%), and 180 grams of damar resin (14.6%). According to batik experts' assessments, the quality of recycled batik wax is equivalent to that of new batik wax. Recycled batik wax has the melting point of 67.9 °C, the viscosity value of 90.15 cP, and the production cost of Rp 30.909,00.
PENGARUH MANAJEMEN SDM TERHADAP KINERJA GURU YAYASAN TUNAS BANGSA DI KOTA TEGAL
Authors: Sulistiadi Andi
Published: March 2024

Generasi 4.0 merupakan era sosial dimana alat-alat teknologi sudah melekat menjadi bagian dari gaya hidup keseharian. Tak terkecuali dengan perilaku guru-guru sebagai praktisi pendidik yang tentunya memiliki hubungan moral yang tidak dapat dipisahakan oleh perangkat canggih yang sudah menjadi bagian dari hidup. Aspek psikologis guru dapat dilihat dari cara pandang manajemen sumber daya manusia yang mampu mengukur kecakapan performa guru yang ternyata dapat terpengaruh oleh tiga aspek manajemen SDM seperti motivasi kerja, kompensasi dan kepuasan kerja. Penelitian ini bertempat di sekolah komersil yang berada dibawah naungan Yayasan Tunas Bangsa kota Tegal. Jumlah responden yang dijadikan objek penelitian adalah guru-guru berjumlah 60 orang. Metode penelitian yang dipakai adalah metode kuantitatif dengan  bantuan software alat olah data Smart PLS versi 3.8.
EKSISTENSI LEMBAGA PENDIDIKAN DITINJAU DARI MUTU
Authors: Hardianto
Published: March 2024

Quality education is a necessity of today's society. Quality education is characterized by internal and external customer satisfaction with educational services. To achieve this quality can be seen from the perspective of the institution and the teacher's perspective. Quality educational institutions are institutions that are able to exist in the midst of competition. This existence can be achieved by an improved culture, improved structure, improved access to resources, improved systems and improved relationships with stakeholders. Qualified teachers are teachers who have been provided with teaching practice programs before becoming professional teachers and mastering certain skills. One of the skills is the mastery of various teaching methods. To achieve quality teachers, teacher competency must always be improved.
Implementasi Pendidikan Karakter dalam Kegiatan Ekstrakurikuler Pramuka di MAN 4 Jakarta
Authors: Siti Rabbaniyah Siti Rabbaniyah , Bedjo Sujanto  , Supadi
Published: March 2024

Abstrak

Tujuan penelitian ini untuk mengetahui secara mendalam tentang nilai-nilai karakter, pengimplementasian, serta faktor-faktor yang memengaruhi keberhasilan dan  menghambat pendidikan karakter.di MAN 4 Jakarta. Penelitian di MAN 4 Jakarta ini dilakukan selama 12 bulan sejak bulan Juli 2018 sampai dengan bulan Juni 2019. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Hasil penelitian menunjukkan bahwa pendidikan karakter dalam kegiatan ekstrakurikuler Pramuka di MAN 4 Jakarta diterapkan secara bertahap dengan memperkenalkan nilai-nilai dasar etika dan akhlaq mulia seperti nilai religius, disiplin, mandiri, kreatif, ramah, peduli lingkungan, tanggung jawab, sopan dan jujur.  Faktor yang mendukung implementasi pendidikan karakter dalam kegiatan ekstrakurikuler yaitu guru, kepala sekolah, siswa, dan orang tua, serta  fasilitas yang memadai.  Faktor yang menjadi kendala dalam implementasi pendidikan karakter terkait dengan waktu pelaksanaan ekstrakurikuler pramuka dan dukungan dari orang tua. Cara mengatasi kendala tersebut dengan melakukan komunikasi yang baik kepada orangtua, melibatkan semua guru, melakukan evaluasi secara rutin dan menetapkan sanksi yang lebih tegas terhadap peserta didik yang tidak menerapkan pendidikan karakter.

 

Kata kunci : implementasi, pendidikan karakter, ekstrakurikuler, pramuka

Abstract

 

The purpose of this study is to find out in depth about character values, implementation, and factors that influence the success and inhibit character education in MAN 4 Jakarta. The research at MAN 4 Jakarta was conducted for 12 months from July 2018 to June 2019. This study used a qualitative approach with a case study method. The results showed that character education in Boy Scout extracurricular activities at MAN 4 Jakarta was implemented in stages by introducing basic ethical and noble values ​​such as religious, disciplined, independent, creative, friendly, environmentally responsible, responsible, polite and honest. Factors that support the implementation of character education in extracurricular activities are teachers, principals, students, and parents, as well as adequate facilities. Factors that become obstacles in the implementation of character education are related to the time extracurricular implementation of scouts and support from parents. How to overcome these obstacles by making good communication to parents, involving all teachers, conducting routine evaluations and setting stricter sanctions on students who do not implement character education.

 

          Keywords: implementation, character education, extracurricular, scout
Project Based Learning Pada Mata kuliah Kewirausahaan Dalam Membentuk Kemandirian Mahasiswa Dalam Berwirausaha
Authors: Irsyad Mohamad
Published: March 2024

This article aims to find ou how project based learning in entrepreneurship courses applied in IAIN Surakarta in shaping students independence in entrepreneurship. This study uses a Classroom Action Research method. This research is describing data, facts and circumstances that occur in the field. The object of this research is 38 students the Arabic Language and Literature, Faculty of Adab and Language IAIN Surakarta. Data collection is done by instruments of student performance and learning outcomes. Performance instruments by assessing student activity in carrying out assignments, conducting business consultations, presenting products, and reporting results. Data from observations were analyzed using qualitative descriptive techniques. In this study it was produced that the application of the project-based learning model could create student independence in producing a product that would ultimately be able to make students economically independent. However, the researchers hope that further research will not only discuss how to apply it, and success in producing products, but also can discuss the business continuity that has been born and create by students.
Improving Productivity Strategies With Failure Mode And Effect Analysis And Analytic Hierarchy Process Methods
Authors: Adrio Muhammad Bayu , Wahyuni Hana Catur
Published: March 2024

UD Fafa Mutiara is a business entity that produces petis as its main product. Products that are considered defective or cannot be repaired and recycled again, will be detrimental to business actors. It is estimated that in each product there are an average of 70 plastic products that are damaged, defective, or even fail, out of 5,000 plastics every month. In a day, Mrs. Ulfa can produce around 175 plastic cases which must be marketed the next day. The purpose of this research is to find out strategies that can improve the quality of UD Fafa Mutiara's petis. One way to find several problems in failure during the petition manufacturing process is known as the Failure Mode and Effect Analysis method, which is abbreviated as FMEA. This method is used to identify potential failures that may occur in the design, production process, or production results. AHP (Analytical Hierarchy Process) has a meaning as a functional hierarchy with the main input being human presumption, which has many advantages in explaining the decision-making process. The research results obtained were that the highest level of risk in the paste production process was when washing raw materials using dirty water with an RPN value of 448. The strategy of using AHP resulted in suggestions for improvements with the highest value, namely checking water with a value of 0.366. So the recommendation that can be given to UD Fafa Mutiara is to maintain the quality of the water used for washing raw materials.

Highlight :

Identification of potential failures: FMEA method helps identify possible failures in design and production processes.

Decision-making process: AHP involves human input to explain decision-making processes effectively.

Risk mitigation strategy: Maintaining water quality during raw material washing is crucial for improving product quality.

Keywords - Petis; production defects; Failure Mode And Effect Analysis (FMEA); Analytic Hierarchy Process (AHP)
Digitization of Precipitation
Authors: Obidova Dilnoza , Hamdamova Dinora , Norboyev Nodir
Published: March 2024

In addressing the challenges posed by outdated and insufficiently documented urban drainage, irrigation, and storm systems, this study aims to revolutionize urban infrastructure through digitalization. Leveraging insights from 25 invited experts representing various organizations, including highway committees, city administration, and city improvement departments, the research focuses on the city of Tashkent. Employing geodesic methodologies, the team meticulously documented the locations and conditions of underground facilities, utilizing city maps and visual aids provided by specialists. The resulting digital database, curated by geodesists, identifies responsible personnel, object types, and areas requiring attention. This innovative initiative not only fills crucial knowledge gaps but also lays the foundation for enhanced maintenance strategies and resource optimization, offering a paradigm shift in urban planning and management.
Highlights:

Comprehensive Digital Mapping: The study employs advanced geodesic techniques to create a detailed digital map of aging drainage, irrigation, and storm systems, offering a comprehensive overview of their current conditions.

Knowledge Integration from Diverse Experts: Gathering insights from 25 experts across various organizations, the research consolidates valuable information on underground facilities, enabling a holistic understanding of the urban infrastructure challenges.

Strategic Resource Optimization: The resulting digital database not only identifies critical maintenance areas but also assigns responsibility, paving the way for strategic resource allocation and efficient urban infrastructure management.

Keyword: Urban Infrastructure, Digitalization, Drainage Systems, Geodesic Mapping, Resource Optimization
Implementation of Three Dimensional Virtual Reality on Android Based AtTanwir Umsida Tower
Authors: Agung Novianto Putra , Dijaya Rohman
Published: March 2024

In the current digital era, many technologies are being developed, one of which is virtual reality or VR technology,VR can be used for various problems in the current era including the introduction of an item, building, etc. At theUniversity of Muhammadiyah Sidoarjo (UMSIDA) itself, the 23 floor At-Tanwir Tower building will be built whichlater have many facilities for educators, students or the community. Of course, an introduction to the current era isneeded, namely VR, with the creation of the Android based At-Tanwir VR Tower, it is hoped that it will be easy torecognize the outdoor/indoor environment of the building and be able to introduce the building to the widercommunity. Later, VR users can look around and explore outside and inside the building from the parking lot, grasses,classrooms, auditorium, theater stage, cafeteria and the observatory room, all of which are three dimensional.
Chronological, Petrogenetic, and Tectonic Significance of Paleoproterozoic Continental Crust within the North China Craton during the Global Tectono-Magmatic Lull
Authors: Liu Heng , Liu Lei , Zhang Dexian , Moon Inkyeong , Santosh M. , Zhou Yanyan , Hu Tianyang , Kang Shisheng
Published: March 2024

The 2.45–2.20 Ga period during the early Paleoproterozoic era is considered to have witnessed a global “Tectono-Magmatic Lull (TML)” and thus marks a relatively quiescent period. Our study unveils a 2.45–2.20 Ga magmatic suite from the Xiong’ershan area in the southern North China Craton, offering some key constraints on localized active tectonics during the TML. Zircon U-Pb dating shows Paleoproterozoic ages for the meta-basalt (2.31, 2.28 Ga), Na-rich meta-andesite (~2.33 Ga), tonalite-trondhjemite-granodiorite (TTG) gneisses (2.36, 2.30 Ga), K-rich granodiorite (~2.29 Ga), and monzogranite (2.33, 2.27 Ga). The meta-basalts geochemically and petrographically belong to calc-alkaline basalts and show distinctive Nb, Ta, and Ti contents and primitive mantle normalized patterns from different places in the Xiong’ershan area. Combined with their enriched εHf(t) values, the magmas were derived from subduction-related enriched mantle sources within a convergent plate boundary. The meta-andesites display high MgO content (average 4.5 wt%) and Mg# (44–57), strongly fractionated rare-earth pattern, calc-alkaline affinity, and negative Nb, Ta, and Ti anomalies. The TTG gneisses are of high SiO2 type (>62 wt%), high (La/Yb)N (17.5, 39.2), and Sr/Y (50.2, 104.3) and mostly display positive Eu anomalies and high-pressure type. Zircons from these rocks show a relatively narrow range of δ18O isotope values (5.35‰, 6.79‰) with εHf(t) isotope characteristics (−9.3, −3.3), suggesting derivation from partial melting of a thickened mafic lower crust. The youngest K-rich granodiorite and monzogranite show high K2O/Na2O ratios (0.65, 2.45). Variable molar ratio Al2O3/(CaO+Na2O+K2O) (A/CNK) and low zircon εHf(t) values suggest that the K-rich granitoids formed from the partial melting of different levels of crust. The presence of meta-basalt to andesite assemblages and diverse intermediate to felsic magmatic rocks implies magmatic activity within a convergent plate boundary tectonic environment with potential influence from plume-triggered extensional processes, supported by evidence of slab rollback and upwelling of mantle material.
Impacto de la fibromialgia en la calidad de vida: El rol mediador de la autocompasión sobre el bienestar subjetivo
Authors: Peña-Muñante Gonzalo Sebastián , Pozo-Muñoz Carmen , Ramos-Rodríguez Carmen
Published: March 2024

La presencia de factores protectores a nivel intrapersonal, como la autocompasión, puede amortiguar la percepción de estrés y los sentimientos de incompetencia y frustración asociados con el impacto de la fibromialgia en la calidad de vida. El objetivo del presente estudio fue explorar la relación entre el impacto de la fibromialgia y el bienestar subjetivo, contemplando la autocompasión como variable mediadora. Participaron 402 mujeres con fibromialgia, a las que se administró un cuestionario para obtener información sobre el impacto de la enfermedad, la autocompasión y el bienestar subjetivo. Se realizaron análisis correlacional y mediacional con SPSS. Los resultados indicaron la existencia de relaciones significativas entre las variables. Además, se encontró un efecto indirecto significativo del impacto de la fibromialgia sobre el bienestar subjetivo a través de la autocompasión. Se concluye que la autocompasión puede mediar parcialmente el efecto del impacto de la fibromialgia sobre el bienestar subjetivo.
Sediment and Groundwater Metagenomes from Subsurface Microbial Communities from the Oak Ridge National Laboratory Field Research Center, Oak Ridge, TN, USA
Authors: Lui Lauren M. , Nielsen Torben N. , Smith Heidi J. , Chandonia John-Marc , Kuehl Jennifer , Song Fangchao , Sczesnak Andrew , Hendrickson Andrew , Hazen Terry , Fields Matthew , Arkin Adam P.
Published: March 2024

We report 26 subsurface sediment and 9 groundwater metagenomes from the Oak Ridge Reservation at Oak Ridge, TN, USA. Samples were collected from various depths and phases (attached vs planktonic) to study subsurface microbial metabolism, the effect of contamination on microbial communities, and differences across groundwater and sediment microbial communities.
Dynamic Covalent Disulfide Exchange Mediates Oral Delivery of Biomacromolecules
Authors: Yang Huanghao , Chen Chen , Huang Tingjing , Liu Zheng , Li Hongjun , Zhang Yang , Liu Xia , Guo Yuheng , Li Jingying , Wu Ting , He Wen , Chen Hao , Rozhkova Elena , Chen Guojun , Chen Zhitong , Chen Zhaowei , Gu Zhen
Published: March 2024

The biological barriers present in the intestine thwart the absorption of orally delivered biologics, which, if overcome, would reduce the injection burdens for millions of patients. Here, we present a straightforward yet effective oral biologic formulation, which utilizes in-situ growing poly(disulfide)s as the sole excipient to circumvent all intestinal barriers in a noninvasive way. We find that, through dynamic covalent disulfide exchange initiated by the thiols in mucins, epithelial membranes, and hepatic sinusoids, digestion-resistant complex coacervates formed from insulin (as a model drug) and guanidinium-containing poly(disulfide)s readily traverse the mucus and epithelial layers without remodeling the barriers’ integrity, and then undergo dissociation to release insulin in the liver. Oral gavage of the complex coacervates with enteric capsules into diabetic mice and swine models elicited a-few-hour longer hypoglycemic effect than subcutaneously injected insulin, attaining relative bioavailabilities over 20%. 14-day dosing experiments demonstrated the postprandial and daily glycemic control capacity and the biosafety of this oral insulin. The generality of this formulation scheme was further validated with human serum albumin and salmon calcitonin.
Intertwined charge-density-wave order in vanadium-based kagome superconductors
Authors: Wu Tao , Sun Kuanglv , Nie Linpeng , Li Hongyu , Zhao Jiyin , Rao Huachen , Yu Fanghang , Shi Mengzhu , Xiang Ziji , Ying Jianjun , Wang Zhenyu , Chen Xianhui
Published: March 2024

In correlated quantum materials, the intertwinement of multiple orders leads to rich exotic quantum states of matter and emergent phenomena. Recently, the discovery of superconductivity and charge density waves (CDWs) with multiple symmetry breakings in kagome superconductors AV3Sb5 (A = K, Rb, Cs) offers a new territory to study intertwined orders. Elastoresistance, which detects the electric resistance in response to an applied strain, offers a unique method to investigate the evolution of intertwined orders in AV3Sb5. Here, we perform a systematic measurement of elastoresistance in two hole-doped CsV3Sb5 series: CsV3Sb5-ySny (y = 0.04 and 0.06) and CsV3-xTixSb5 (x = 0.03, 0.05 and 0.09). Below the CDW transition temperature (TCDW), the elastoresistance coefficient in all samples undergoes a jump-like transition at TCDW and then another kink-like transition at a lower temperature (T*). Based on a Ginzburg-Landau analysis of CDW order, the jump-like transition at TCDW is well explained by a triple-Q CDW driven by lattice instability, while the kink-like transition around T* is ascribed to an interaction-driven quantum melting of triple-Q CDW, which leads to a nematic CDW state at low temperatures. Interestingly, the T* in all samples follows a perfect anti-correlation with the superconducting transition temperature (Tc), indicating an intertwinement of superconductivity and nematic CDW. Strikingly, the elastoresistance coefficient of Sn-doped samples exhibits a distinct temperature dependence from that of pristine and Ti-doped samples above TCDW, which is ascribed to a charge stripe instability enhanced by Sn doping. Our present findings provide a new perspective to understand the intertwined orders in kagome superconductors AV3Sb5.
Periocular lid oncology referral pathway - A need for standardised proforma? An analysis of 199 patients
Authors: Malik Mohsan , Giannakis Periklis , Iakovlev Ernest , Daniel Claire , Gupta Tarang , Kang Swan
Published: March 2024

Purpose
To evaluate the accuracy of the Local-Regional 2-week wait (2WW) referral pathway for peri-ocular cancers.
Methods
Clinicodemographic and pathological data available on our electronic health records were extracted for patients referred to specialist periocular oncology service under the suspected eyelid cancer pathway between July 2019 and May 2022. Descriptive statistics were computed along with the chi-square exact test to determine the statistical significance between the referrals and referrals that were rejected/downgraded on the biopsy and biopsy-proven cancer diagnosis rates.
Results
199 referrals were included for analysis. 145 of these were from accepted 2WW pathway referrals. Most were referred using the regional suspected ocular tumour form through their general practitioner, 113/145 (78%). The average time to be first seen at our service from the initial referral was 11 days (± 5). 81 out of 145 patients (56%) underwent biopsies with a cancer diagnosis yield of 14/81 cases (17%). The most common cancer diagnosis was basal cell carcinoma representing 12/81 (15%) of all biopsy-proven diagnoses.
Conclusion
We found the overuse of urgent suspected periocular cancer referral care pathway attributable to incomplete referral information. We recommend the development of a peri-ocular cancer-specific referral form to reduce the burden on services, focusing care to patients who require urgent referrals. More education is required for referring clinicians to ensure they are aware of benign peri-ocular conditions and prevent undue stress to patients. The generalisation of these findings outside the UK population requires corroboration internationally.
Optimal seasonal schedule for the production of isoprene, a highly volatile biogenic VOC
Authors: Iwasa Yoh , Hayashi Rena , Satake Akiko
Published: March 2024

The leaves of many trees emit volatile organic compounds (abbreviated as BVOCs), which protect them from various damages, such as herbivory, pathogens, and heat stress. For example, isoprene is highly volatile and is known to enhance the resistance to heat stress. In this study, we analyze the optimal seasonal schedule for producing isoprene in leaves to mitigate damage. We assume that photosynthetic rate, heat stress, and the stress-suppressing effect of isoprene may vary throughout the season. We seek the seasonal schedule of isoprene production that maximizes the total net photosynthesis using Pontryagin's maximum principle. The isoprene production rate is determined by the changing balance between the cost and benefit of enhanced leaf protection over time. If heat stress peaks in midsummer, isoprene production can reach its highest levels during the summer. However, if a large portion of leaves is lost due to heat stress in a short period, the optimal schedule involves peaking isoprene production after the peak of heat stress. Both high photosynthetic rate and high isoprene volatility in midsummer make the peak of isoprene production in spring. These results can be clearly understood by distinguishing immediate impacts and the impacts of future expectations. (195 words)
Optimizing Germination conditions of Ghaf Seed using ZnO Nanoparticle priming through Taguchi Method Analysis
Authors: Francis Dali V. , Subhan Abdul , Mourad Abdel-Hamid I. , Abdalla Abdelmoneim K. , Ahmed Zienab F. R.
Published: March 2024

Ghaf, a resilient tree in arid environments, plays a pivotal role in ecological restoration, desertification mitigation, and cultural heritage preservation. However, the seeds' inherent challenges, notably their hard outer coating restricting germination, emphasize the pressing need for innovative strategies. This work aimed to investigate the optimization of Ghaf seed germination process through seed priming with ZnO nanoparticles treatment (duration (t), concentration (c), temperature (T) and agitation (a), employing the Taguchi method for efficient experimental design. Notably, it revealed that concentration is a pivotal influencer in the optimization of Ghaf seed. The results showed that the concentration of ZnO nanoparticles has no linear relation with any other parameters. To verify the outcomes, validation tests were performed utilizing the predicted optimal parameters. The observed low error ratio, falling within the range of 1–6%, confirmed the success of the Taguchi methodology in identifying optimal levels of the factors chosen. Significantly, ZnO-primed seeds showcased a remarkable enhancement in Ghaf seed germination, increasing from 15–88%. This study introduces a novel approach utilizing ZnO nanoparticle treatment optimized through the Taguchi method, significantly enhancing seed germination rates of Ghaf seeds and offering a promising avenue for sustainable agricultural practices in arid environments.
Resection Combined with Hyperthermic Intra-peritoneal Chemotherapy Prevents Peritoneal Implantation Metastasis of Hepatocellular Carcinoma with Spontaneous Rupture
Authors: Feng Zhou-bin , Xu Yu-yan , Zhang Cheng , Wen Yao-hong , Feng Jia-nan , Pei Jing-yuan , Tan Hong-kun , Wang Chun-ming , Liu Wen-xuan , Cai Lei , He Guo-lin , Fu Shun-jun , Pan Ming-xin
Published: March 2024

Background
Hepatocellular carcinoma with spontaneous rupture (rHCC) is managed through conservative treatment, emergency resection, and trans-arterial embolisation. However, peritoneal implantation metastasis (PIM) remains highly likely owing to intraperitoneal free cancer cell dispersion within the abdominal cavity before achieving haemostasis. Although resection combined with hyperthermic intra-peritoneal chemotherapy (R-HIPEC) is used in cancer treatment, its effectiveness in preventing PIM of rHCC remains uncertain. This study aimed to evaluate the effectiveness of R-HIPEC in reducing peritoneal implantation metastasis of rHCC.
Methods
Data from 83 rHCC patients treated at Zhujiang Hospital of Southern Medical University between February 2013 and July 2023 were retrospectively analysed. Patients were categorised into interventional, resection, and R-HIPEC groups. PIM rates, time to recurrence-free survival (RFS), survival time, and other risk factors were analysed using the logistic or Cox regression model. Variables with P < 0.1 in the univariate analysis were included in the multivariate analysis.
Results
The resection and intervention groups showed no significant differences in PIM (64.5% vs 61.9%, P = 0.848), RFS (3.7 vs 4.3 months, P = 0.852), and overall survival (OS) (20.5 vs 6.9 months, P= 0.054). The R-HIPEC group exhibited lower PIM rates (23.1% vs 63.5%, P= 0.009) and longer OS (P = 0.045) than the non-HIPEC group, and the median OS was not reached in the R-HIPEC group. The R-HIPEC group had superior RFS (5.8 vs 3.6 months, P = 0.084) than the non-HIPEC group; however, the difference was not statistically significant. Multivariate analysis revealed that R-HIPEC was associated with lower PIM (odds ratio: 0.235, 95% confidence interval 0.056–0.981, P = 0.047).
Conclusions
R-HIPEC significantly reduced the occurrence of PIM, extended the RFS and OS in rHCC patients, and enhanced the overall prognosis.
Design of Sulfonamide-Based Glycosides Incorporated with 1,2,3-Triazole Scaffold as Potential VEGFR-2 and Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxic Activity and In Silico Studies
Authors: El-Bayaa Mohamed N. , Nossier Eman S. , El-Manawaty May A. , Abbas Hebat-Allah S.
Published: March 2024

The current study reports new sulfonamide-triazole-glycoside hybrids' design, synthesis, and anticancer activity. The target glycosides' cytotoxic activity was studied with a panel of human cancer cell lines. Azido sulfonamide compound 4 exhibited moderate activity against A-549 and HCT-116 and excellent potency against HepG-2 and MCF-7. Replacement of the azido group with 1,2,3-triazole- glycoside hybrids in 6-13 afforded variable activities against tested cell lines ranging from weak to excellent ones in acetylated glycosides 6-9. On the other hand, hydroxylated glycosides 10-13, revealed weak cytotoxicity except N-cyclohexylbenzene derivatives 11, 13 expressing promising activity against HepG-2.
In addition, the hydroxylated glycoside 13 gave moderate activity against MCF-7. To detect the probable action mechanism, the inhibitory activity of the promising sulfonamide-triazole-glycoside hybrids was studied against VEGFR-2, carbonic anhydrase isoforms hCA IX and hCA XII. Moreover, the docking evaluation was simulated to supply better rationalization and gain insight into the binding affinity between their targeted enzymes and the promising derivatives and used for further modification in the anticancer field.
Study of the optical rotation of potassium titanyl phosphate using the advanced dual-wavelength polarimetric method
Authors: Shopa Mykola , Ftomyn Nazar , Shopa Yaroslav
Published: March 2024

An advanced dual-wavelength high-accuracy universal polarimeter was applied to measure optical activity in potassium titanyl phosphate (KTP) nonlinear crystal. Two single-mode He-Ne lasers with close wavelengths of 594 and 633 nm were used as light sources in the experimental setup. Multiple internal reflection of the light was taken into account when processing the results of the polarimetric measurements. Analysis of the optical transmission function for the polarizer-sample-analyzer system and 2D intensity contour maps made it possible to determine the phase parameters, systematic errors, and eigenwaves ellipticity. Gyration tensor component of the KTP crystal is equal to g12 =1.4 · 10-5 which in terms of optical rotatory power corresponds to the value of 2.3 deg/mm.
Identification of genes involved in the tomato root response to Globodera rostochiensis parasitism under varied light conditions
Authors: Matuszkiewicz Mateusz , Święcicka Magdalena , Koter Marek , Filipecki Marcin
Published: March 2024

Understanding the intricate interplay between abiotic and biotic stresses is crucial for deciphering plant responses and developing resilient cultivars. Here, we investigate the combined effects of elevated light intensity and nematode infection on tomato seedlings. Chlorophyll fluorescence analysis revealed significant enhancements in PSII quantum yield and photochemical fluorescence quenching under high light conditions. qRT-PCR analysis of stress-related marker genes exhibited differential expression patterns in leaves and roots, indicating robust defense and antioxidant responses. Despite root protection from light, roots showed significant molecular changes, including down-regulation of genes associated with oxidative stress and up-regulation of genes involved in signalling pathways. Transcriptome analysis uncovered extensive gene expression alterations, with light exerting a dominant influence. Notably, light and nematode response synergistically induced more differentially expressed genes than individual stimuli. Functional categorization of differentially expressed genes upon double stimuli highlighted enrichment in metabolic pathways, biosynthesis of secondary metabolites, and amino acid metabolism, whereas the importance of specific pathogenesis related pathways decreased. Overall, our study elucidates complex plant responses to combined stresses, emphasizing the importance of integrated approaches for developing stress-resilient crops in the face of changing environmental conditions.
Cross-cultural adaptation of the Pelvic Floor Dysfunction SENTINEL screening tool for German-speaking female athletes
Authors: Albers Nina , Huebner Markus , Giagio Silvia , Turolla Andrea , Pillastrini Paolo , Stein-Brueggemann Daniela , Rudolph Finja , Juhasz-Boess Ingolf , Hollander Karsten , Marques Carlos
Published: March 2024

Introduction: Pelvic floor dysfunction (PFD), such as urinary or fecal incontinence or pelvic organ prolapse, is a common medical condition with increasing awareness in female athletes since they suffer more frequently from PFD than non-athletes. For female athletes PFD can be very disabling and stressful and may even lead to withdrawal from sport. Recently, a screening tool for PFD in female athletes was introduced (PFD-SENTINEL screening tool). In this study, we aimed to translate and culturally adapt the PFD-SENTINEL screening tool into German. Methods: Following an international guideline, forward and backtranslations of the screening tool were conducted throughout six progressive phases. A pre-final version of the PFD-SENTINEL screening tool for the German language was tested in a cohort of 27 potential users. Subsequently, a final version was adjusted and presented. Results: Twenty-two of the 27 potential users were female athletes (median age 24 years). Five of the potential users were healthcare professionals (median age 28 years). None of the participants had difficulties understanding the questionnaire, either linguistically or in terms of content. The final version was approved by the original developers. Conclusions: The PFD-SENTINEL screening tool holds promise to prompt specialist care and assessment, detecting potential PFD and helping to estimate the related prevalence in female athletes. Its successful translation and adaptation to the German language allows for future testing of its psychometric properties and application in German-speaking regions.
Relationship between Mutant Genes, SNPs and Mutation Types in Children with Hyperthyroidism Based on Canonical correlation Analysis
Authors: Mao Xiaojian , Tang Liangliang , Wang Heyong , Li Hongyi , Shao Yongxian , Liu Li , Zhang Wen , Headar Abdalbari
Published: March 2024

Objective
Generally, different mutation types affect patients to various degrees. Some mutation types, such as synonymous mutations, do not cause changes in amino acid sequence and have little impact on patients. In contrast, some types of mutations will lead to wrong encoding or stop encoding of amino acid sequences, which will have a more significant impact on patients. Therefore, this paper intends to find the genetic characteristics of hyperthyroidism in children from the perspective of mutation types: missense mutations, synonymous mutations, nonsense mutations, and splice site mutations, and explore the relationship between mutant Genes, SNPs, and mutation types in patients. Finally, find the mutation type in which the specific mutant gene and the mutation site were biased.
Methods
Use the canonical correlation analysis method to find the relationship between the mutant gene, the mutation site, and the mutation type.
Results
Based on the complete linear correlation, single value, and Pearson correlation coefficient, screen the mutant genes and SNPs, then get 23 representative mutant genes from 144 mutant genes in 39 children and 8 representative SNPs from 1221 SNPs in 39 children. Canonical variables were constructed using data from representative mutant genes, SNPs, and their corresponding mutation types for canonical correlation analysis. A significant positive correlation between the mutant gene and the mutation type and a significant positive correlation between SNPs and the mutation type were found through canonical variable correlation and significance tests.The mutant genes for children with hyperthyroidism consist of 23 representative mutant genes, among which the genes ACADM, ATM, BARD1, CALCA, CAPN3, CRP, DNMT1, DNMT3A, FANCC, GHRL, KANK1, LRSAM1, TPO, TSHR, VWF are all prone to missense mutations, nonsense mutation, and synonymous mutation, the gene CGA is prone to splice site mutation. Among the 23 genes, the gene KANK1 has the greatest impact on the ensemble of mutant genes. SNPs for children with hyperthyroidism consist of 8 representative SNPs, among which g.1529224C > T, g.23019637C > G and g.44651599T > C are prone to missense mutations, g.1533961C > T, g.12718004G > A, g.43082453A > G, g.44652143G > A and g.71809992C > T are prone to synonymous mutations. The site g.44651599T > C has the greatest impact on the ensemble of SNPs.
Conclusion
There is a strong correlation between gene mutation types and mutant genes and between mutation types and SNPs in children with hyperthyroidism. Each mutant gene and SNP has a more preferred mutation type, among which gene CGA and gene KANK1 may be the mutant gene that has the most significant impact on children, and SNP g.44651599T > C may be the SNP that has the greatest impact on children.