bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis kestabilan lereng desain Disposal WDNW Tutupan tahun 2018 pada PT Adaro Indonesia, Propinsi Kalimantan Selatan
Authors: Nurahma Asti Puspita , Nurhakim Nurhakim , Hakim Romla Noor
Published: January 2022

Kestabilan lereng disposal menjadi hal yang sangat penting demi kelangsungan suatu pertambangan agar sesuai dengan yang direncanakan. Selain geometri lereng, karakteristik dari material timbunan mempengaruhi dari segi kekuatannya. Perluasan disposal akan menimbunan ex-settling pond dimana terbentuknya sedimentasi lumpur. Hal ini menjadi perhatian lebih karena menyangkut masalah keamanan dan keselamatan pekerja.Penelitian ini diawali dengan uji lapangan Standard Penetration Test (SPT) yang mana nilai tumbukan dimasukan ke dalam persamaan agar mendapat nilai kohesi tanah. Proses selanjutnya adalah menentukan input material properties yang digunakan untuk melakukan analisis kestabilan lereng overall slope pada bongkaran dari Pit North Tutupan untuk mengetahui nilai safety factor-nya.Nilai safety factor minimum yang dipakai sebagai batas kritis adalah 1,2. Analisis menggunakan metode kesetimbangan batas yaitu metode Morgenstern-Price dengan bantuan software Slide versi 6.0 dari Rocscience. Dari hasil analisis 11 sayatan, diperoleh nilai safety factor desain lereng tidak mencapai 1,2. Untuk lereng keseluruhan sayatan E-E’ belum stabil dengan nilai safety factor sebesar 1,016 dan sayatan J-J’ nilai SF yang dihasilkan sebesar 1,194. Dengan hasil ini, maka perlu upaya penanggulangan untuk mencegah terjadinya gangguan kestabilan lereng disposal seperti merancang ulang geometri lereng dan melakukan treatment sludge bila perlu.
ANALISIS KOMPARASI KEMAMPUAN MENULIS ILMIAH PESERTA DIDIK DITINJAU DARI MODEL PEMBELAJARAN PROYEK YANG DIPADUKAN DENGAN KLINIK LITERASI SAINS PADA TEMA COVID-19
Authors: Indarwati Rosi , Arif Syaiful
Published: January 2022

Abstrak. Pengenalan mengenai menulis ilmiah seharusnya sudah dimulai dari jenjang menengah pertama (SMP) sehingga peserta didik akan lebih mudah menyesuaikan pada jenjang belajar selanjutnya. Oleh sebab itu guru berupaya untuk mengenalkan dan meningkatkan kemampuan menulis ilmiah peserta didik dengan penerapan model pembelajaran proyek yang dipadukan dengan klinik literasi sains. penelitian dilakukan pada kelas VIII MTs Al Ishlah Kebonsari Madiun. Kemudian data yang diperoleh dianalisis menggunakan analisis deskriptif kuantitatif dan menggunakan uji statistik Uji-t (Two tailed dan One tailed) menggunakan Minitab 16. Data yang diperoleh sebelumnya telah dilakukan uji homogenitas dan reliabilitas. Dari hasil penelitian didapatkan P-Value sebesar 0.000 kurang dari 0,05 maka H0 ditolak atau kemampuan menulis peserta didik kelas eksperimen yang menggunakan model pembelajaran proyek dipadukan dengan klinik  literasi sains berbeda dengan kemampuan menulis kelas kontrol yang menggunakan  model pembeajaran konvensioanal. Untuk mengetahui kelas mana yang lebih baik maka dilakukan uji-t one tailed yang menghasilkan  estimate for different kelas eksperimen terhadap kelas kontrol sebesar 13,76 yang berarti  kelas eksperimen lebih baik dibandingkan dengan kelas kontrol.berdasarkan nilai post test kelas kontrol mendapatkan rata-rata nilai sebesar 65,8 dan kelas eksperimen mendapat rata-rata sebesar 79,58. Hasil ini menunjukkan kelas eksperimen lebih baik dibandingkan dengan kelas kontrol. Abstract.  Introduction to scientific writing should have started in the middle class so that learners could more easily adjust to the next study. Thus the teacher seeks to introduce and improve the ability to write scientifically learners with the application of project learning models combined with science literacy clinics. Studies were carried out during eighth grade MTS al ishlah kebonsari. Then the data acquired is analyzed using a quantitative descriptive analysis and using the uji-t statistic test (two tailed and one tailed) using minitab 16. Previously acquired data has been done with homogeneity and religious testing. With the value of research generated at $10,000 less than 0.05, h0 was rejected or the ability to write students experiment classes using project learning models blended with conventional control clinics. To find out which class is better then do a uji-t one tailed that produces an experiment for different classes on a control class of 1376 which means an experimental class is better than a control class. Based on the control post test scores get the average value of 65.8 and the experiment class gets an average of 79.58. These results suggest experiment classes are better than control class..
PENGEMBANGAN E-MODUL PEMBELAJARAN IPA SMP KELAS VII BERBASIS MODEL PEMBELAJARAN LEVELS OF INQUIRY UNTUK MENINGKATKAN LITERASI SAINS SISWA
Authors: Mijaya N. P. Anggi Putri , Sudiatmika A. A. I. Agung Rai , Suardana I Nyoman
Published: January 2022

Penelitian ini bertujuan menghasilkan e-modul pembelajaran IPA berbasis model pembelajaran Levels of Inquiry yang valid, praktis, dan efektif untuk meningkatkan literasi sains siswa SMP kelas VII. Jenis penelitian ini adalah penelitian pengembangan (Research and Development) dengan menggunakan model pengembangan ADDIE oleh Dick dan Carey, meliputi 1) analisis, 2) perancangan, 3) pengembangan, 4) implementasi dan 5) evaluasi.  Data pada penelitian ini dikumpulkan dengan teknik pemberian angket dan tes literasi sains. Adapun rancangan penelitian untuk uji keefektivitasan menggunakan One Group Pretest-Posttest Design. Data hasil penelitian di analisis secara deskriptif. Hasil penelitian menunjukkan bahwa (1) e-modul sangat valid dari segi materi (KVG=0,89), media (x ̅=96,75), dan bahasa (x ̅=97,45) (2) e-modul sangat praktis dari praktisi guru (x ̅=91,83) dan praktisi siswa (x ̅=91,53), (3) e-modul efektif meningkatkan literasi sains siswa dengan kualifikasi sedang (=0,52). Berdasarkan hasil penelitian, dapat disimpulkan bahwa produk e-modul pembelajaran IPA SMP kelas VII berbasis model pembelajaran Levels of Inquiry untuk meningkatkan literasi sains siswa memperoleh penilaian yang valid, praktis dan efektif.
PENGEMBANGAN LKPD DIGITAL MENGGUNAKAN PENDEKATAN SAINTIFIK BERBASIS KREATIVITAS MATA PELAJARAN KIMIA MATERI PEMBUATAN MAKANAN BERUPA KOLOID
Authors: Lavtania Neysia , Nulhakim Lukman , Utari Enggar
Published: January 2022

Tujuan penelitian ini untuk menganalisis dan mendeskripsikan langkah-langkah, pengembangan LKPD digital menggunakan pendekatan saintifik berbasis kreativitas. Penelitian ini dilakukan pada peserta didik kelas XI SMAN 1 Kalanganyar dengan materi pembuatan makanan berupa koloid, metode yang digunakan adalah R&D yang merujuk pada model  ADDIE dengan lima tahap yaitu yaitu 1) Analisis  2) Desain 3) Pengembangan  4)Implementasi dan 5) Evaluasi. Validasi dilaksanakan pada ahli media dan ahli materi, kemudian uji coba dilakukan kepada peserta didik. Data yang dihasilkan dari  uji coba berupa instrumen, dianalisis dengan mendiskripsikan kelayakan produk LKPD digital melalui validitas analisis rata-rata LKPD digital. Kelayakan validasi ahli materi sebesar 85%, ahli media 81,25% dengan kategori sangat layak. Setelah divalidasi selanjutnya di uji cobakan pada peserta didik sehingga diperoleh persentase kesesuaian jawaban LKPD digital menggunakan pendekatan saintifik berbasis kreativitas diperoleh nilai rata-rata sebesar 89% kategori sangat efektif. Hasil respon peserta didik tehadap LKPD digital sebesar 93%. Dengan demikian, penelitian ini dapat disimpulkan bahwa lembar kerja peserta didik (LKPD) digital menggunakan pendekatan saintifik berbasis kreativitas mata pelajaran kimia materi pembuatan makanan berupa koloid dapat digunakan oleh peserta didik kelas XI SMA Negeri 1 kalanganyar.
PENGEMBANGAN PENUNTUN PRAKTIKUM KIMIA DASAR INOVATIF TERINTEGRASI PENDEKATAN GUIDED INQUIRY UNTUK MENGEMBANGKAN KETERAMPILAN PROSES BELAJAR MAHASISWA
Authors: Pane Eva Pratiwi , Simangunsong Anita Debora
Published: January 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kelayakan penuntun praktikum kimia dasar inovatif dalam perkuliahan kimia dasar dan mengetahui perbedaan hasil belajar mahasiswa yang menggunakan penuntun praktikum kimia dasar inovatif terintegrasi pendekatan guided inquiry pada materi laju reaksi. Lokasi penelitian di Universitas HKBP Nommensen Pematangsiantar. Sampel penelitian diambil sebanyak 30 mahasiswa. Data pada penelitian ini diperoleh dari lembar observasi aktivitas siswa dan tes hasil belajar siswa. Teknik pengumpul data menggunakan lembar aktivitas dan tes objektif dalam bentuk pilihan ganda yang terdiri dari 20 soal. Teknik analisis data menggunakan metode analisis deskriptif kualitatif berdasarkan penjelasan deskriptif hasil wawancara dan beberapa komentar dari validator. Berdasarkan hasil penilaian lembar observasi aktivitas siswa diperoleh nilai masing-masing observer I 89,3; observer II 77,3 dan observer III 78,2. Hasil tes objektif menunjukkan peningkatan hasil belajar rata-rata gain sebesar 0,52 berada pada kategori sedang yang merupakan peniaian dari ranah kognitif. Sehingga dapat disimpulkan bahwa penuntun praktikum kimia dasar inovatif terintegrasi pendekatan guided inquiry untuk meningkatkan keterampilan proses mahasiswa dapat meningkatkan hasil belajar mahasiswa pada materi laju reaksi.
Realization of metabolic risk factors in adolescents born prematurely, depending on the features of eating behavior
Authors:   Siberian State Medical University, Tomsk, Russian Federation, Rafikova Yu.S. , Podporina M.A. ,   Siberian State Medical University, Tomsk, Russian Federation, Saprina T.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Mikhalev E.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Zhelev V.A. ,   Siberian State Medical University, Tomsk, Russian Federation, Loshkova E.V. ,   Siberian State Medical University, Tomsk, Russian Federation
Published: January 2022

Objective. To determine the incidence of metabolic syndrome components in adolescents born prematurely, depending on the presence of eating disorders. Patients and methods. Group I (n = 58) included adolescents who were born preterm. In group II (n = 65), there were adolescents born full-term. The mean age of participants was 12.3 years. To diagnose metabolic syndrome, the criteria of the International Diabetes Federation (2009) were used. Eating behavior of adolescents was studied using the Dutch Eating Behavior Questionnaire (DEBQ). Results. Overweight was statistically significantly more frequent among adolescents born preterm (36% versus 9% in the comparison group, OR 5.7; 95% CI 2.2–15.2) as well as visceral fat accumulation (36% versus 6%, OR 8.8; 95% CI 2.9–27.2) and stage 1 hypertension (35% versus 2%, OR 33.8; 95% CI 4.4–261.3). Eating disorders in adolescents born prematurely differed by gender: boys were more likely to have eating disorders (emotional and external eating, and their combination, 73%) than girls (36%, OR 4.4; 95% CI 1.5–13.2). Conclusion. The realization of metabolic risk factors in adolescents born preterm is affected not only by eating disorders but also by premature birth itself. Key words: metabolic syndrome, prematurity, eating behavior, adolescents born preterm
ANALISIS PSIKOLOGI DAN NILAI PENDIDIKAN KARAKTER DALAM NOVEL MATA DI TANAH MELUS SERTA PEMANFATAANNYA DALAM PEMBELAJARAN SASTRA
Authors: Kinanti Ainidya Marhaenita , Andayani Andayani , Suyitno Suyitno
Published: January 2022

The objectives of this research are to describe and explain (1) the structure of  novel Mata di Tanah Melus by Okky Madasari; (2) the psychological aspects of main character in the novel based on human needs’ theory by Abraham Maslow; (3) the value of education character in the novel Mata di Tanah Melus; (4) to describe relevance in the novel with literature learning in the junior high school. This research used a qualitative descriptive method in psychology literature to describe psychological aspects of the main character. The data source of this research is the novel entitled Mata di Tanah Melus by Okky Madasari publised Gramedia Pustaka Utama. The validaty data used the triangulation data source. The results show that (1) the novel structures are theme, character and characterization, plot, and setting; (2) the psychplogical aspect of main character based of human needs’ theory are included; a physiological needs, the needs of savety, love and belonging, esteem of Matara are not fulfill well; (3) the most dominant value of caracter education is curiosity; (4) the relevance of the novel with literature learning in the junior high school based on the results of interviews.
KEMAMPUAN MENULIS TEKS DESKRIPSI SISWA SEKOLAH MENENGAH KEJURUAN
Authors: Purbania Basyaroh , Rohmadi Muhammad , Setiawan Budhi
Published: January 2022

This study aims to describe ability, results percentage, difficulties faced, and how to overcome students' difficulties in writing description compositions seen from the aspects of content, organization, effective sentence mastery, vocabulary, and mechanics in class XI AP1 SMK Batik 2 Surakarta. This study is a descriptive qualitative using a case study approach. The sampling technique used in this study is purposive sampling. The data sources in this study are documents (students’ description composition) and informants (teachers and students). Data collection techniques are carried out by document analysis and in-depth interviews. Data validity is done by data triangulation techniques, theories, and informant reviews. Data analysis techniques use interactive models, namely data collection, data reduction, data presentation, and conclusion drawing. The results of the study are as follows. The ability results to be included in the category pretty good with vulnerable grades of 61-75. Furthermore, the results percentage of each aspect included the content aspect of 19%, the organizational aspect of 22%, the effective sentence mastery aspect by 16%, the vocabulary aspect by 24%, and the mechanical aspect by 19%. The influence of the writing description composition ability is caused by the difficulties faced by students in writing, namely: difficult to express ideas, difficult to develop sentences, difficult to determine good and right spelling, and difficult to concentrate. The solutions are: create an outline, look for sources of inspiration, use the enhanced spelling handbook, and more time to study (writing practice).
ANALISIS TEKS DAN KONTEKS TEKS DRAMA KARYA SISWA SEKOLAH MENENGAH ATAS
Authors: Sasongko Hari Agus , Wardani Nugraheni Eko , Suhita Raheni
Published: January 2022

This study aims to determine the textual and contextual aspects of the drama text by the class XI SMA Negeri 1 Sukoharjo school year 2016-2017. The research used in this study is analysis of the content analyses with a qualitative approach. The primary Data used in this study was a collection of drama text by the XI SMA Negeri 1 Sukoharjo class. The secondary Data used is the form of articles, books, journals and research results conducted by some researchers. The Data used is taken by the purposive sampling method. To test the validity/validity of data in this study using the source triangulation techniques, and triangulation theory. The results of the study were 179 reference data, 23 60 data for the The researchers found three reference data, i.e. persona, demonstrative, and comparative references. The details are as follows: There are 122 data-refering personas, 41 demonstration reference data, and 16 comparative refering. In the drama text by the class XI SMA Negeri 1 Sukoharjo also found a lexical aspect. The lexical aspects found are: (1) Reps, (2) Sinonimi, (3) Antonimi, and (4) collocations. Details are as follows: 37 data reps, 6 data Sinonimi, 12 data Antonimi, and 16 colocation data. In this study there were four principles that became a reference in the contextual analysis of the drama text, namely: 1) The principle of personal interpretation, 2) The principle of locational interpretation, 3) The principle of temporal interpretation, and 4) the principle of analogy. Based on this, it can be noted that there is a conjugual element in the collection of drama text by the students of the class XI SMA Negeri 1 Sukoharjo. The manuscript of a drama text by SMA Negeri 1 Sukoharjo is a textual aspect, lexical and grammatically. There are four principles that are referenced in the contextual analysis of the drama text, i.e. personal interpretation principles, locational interpretation principles, temporal interpretation principles, and analogy principles.
ANALISIS STRUKTURALISME GENETIK DAN NILAI PENDIDIKAN KARAKTER NOVEL MARYAM KARYA OKKY MADASARI SEBAGAI BAHAN AJAR SASTRA DI SEKOLAH MENENGAH ATAS
Authors: Dewi Laeli Rohmawati , Rohmadi Muhammad , Suhita Raheni
Published: January 2022

This study aims to describe the intrinsic elements of the novel 1) Maryam by Okky Madasari; (2) the author's view of the world; (3) the value of character education in the novel of Maryam; and (4) the relevance of the novel of Maryam as the materials literature in high school. The research of applying qualitative methods with genetic structuralism approach. Data and data sources this research is the archives/documents and informants. Research subject retrieval technique used the purposive sampling. The technique of data collection used the analysis of documents and in-depth interviews. The validity of the data used triangulation theory and sources. Data analysis technique used analysis of the flow. Results of the study are: (1) there is  relationship between substance of the novel of Maryam includes themes, characters and characterization, setting, plot, point of view, and value; (2) the author's world view includes the religious view, humanism, and feminism; (3) the story in the novel of Maryam contains 10 values character education includes religious tolerance, hard working, independent, democratic, curiosity, friendly/communicative, social care, and responsibility; (4) the novel Maryam relevant with learning materials of literature in high school especially in KD (3.8) Interpret the author's view on life in the novel is read and Analyze (3.9) and linguistic content of the novel.
NILAI PENDIDIKAN KARAKTER DAN NILAI SOSIAL DALAM NOVEL AROK DEDES KARYA PRAMOEDYA ANANTA TOER SERTA PEMANFAATANNYA SEBAGAI BAHAN AJAR CERITA SEJARAH SISWA SMA
Authors: Mitaviana Amaylia Galuh , Suwandi Sarwiji , Setiawan Budhi
Published: January 2022

This study aims to describe and explain: (1) the value of character education (moral) in the novel Arok Dedes by Pramoedya Ananta Toer, (2) the social values contained in the novel Arok Dedes by Pramoedya Ananta Toer, and (3) the use of character education values and social values in the novel Arok Dedes as the development of historical story teaching materials for high school students. The data source in this study is the novel Arok Dedes by Pramoedya Ananta Toer. The method used is descriptive qualitative with a content analysis approach. Sources of data used are novel documents of Arok Dedes and informants. The sampling technique used purposive sampling. Data collection techniques using document analysis techniques and interviews. The data validity was done by theory triangulation and source triangulation. The data analysis technique in this research is content analysis. The results of this study are (1) there are character education values (moral), including ing ngarso sung tuladha, ing madya mangun karsa, tut wuri handayani, honesty, justice, tolerance, wisdom, self-discipline, cooperation, courage, and democracy; (2) social values, including the values of love, devotion, help, kinship, loyalty and care; and (3) novel Arok Dedes deserves to be used as teaching material for class XII SMA because it contains character education values. The most dominant character education value is justice, and the dominant social value is kinship.
ALIH KODE DAN CAMPUR KODE DALAM FILM "PARIBAN DARI TANAH JAWA" KARYA ANDIBACHTIAR YUSUF
Authors: Tanjung Josua
Published: January 2022

Penelitian ini bertujuan untuk mendeskripsikan (1) bentuk alih kode dan campur kode dan (2) faktor penyebab terjadinya alih kode dan campur kode pada film Pariban dari Tanah Jawa karya Andibachtiar Yusuf. Penelitian ini adalah penelitian kualitatif. Pengumpulan data dilakukan dengan teknik simak dan dilanjutkan dengan teknik catat. Keabsahan data dalam penelitian ini menggunakan teknik tringulasi teori. Teknik analisis data yang digunakan dalam penulisan ini adalah deskriptif kualitatif. Hasil penelitian adalah sebagai berikut: Pertama, gejala alih kode melibatkan pemakaian bahasa Batak, bahasa Indonesia, dan bahasa Inggris. Gejala campur kode melibatkan pemakaian bahasa Batak, bahasa Inggris, dan bahasa Indonesia. Kedua, faktor penyebab terjadinya alih kode berkaitan dengan hubungan penutur dengan mitra tutur, latar tempat, sosial, budaya dan situasi pembicaraan. Faktor penyebab campur kode berkaitan dengan faktor ekstralinguistik dan intralinguistik.
MAIN CAUSES OF EXCESS MORTALITY IN RUSSIA IN THE CONTEXT OF THE COVID-19 PANDEMIC
Authors:   Novosibirsk State Pedagogical University, Novosibirsk, Russia, Goroshko N,V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Patsala S.V. ,   Novosibirsk State Pedagogical University, Novosibirsk, Russia
Published: January 2022

Significance. The COVID-19 pandemic has had a significant impact on the mortality rates in Russia. In order to objectively assess mortality, scientists propose to calculate and analyze the scale of excess mortality, which is a more comprehensive indicator of the overall impact of the pandemic on population loss compared to the number of deaths from COVID-19. The purpose of the study is to identify the scale of excess mortality in Russia in the context of the COVID-19 pandemic and its determining factors. Material and methods. The information base of the study was made up of the Rosstat demographic statistics, as well as publications in the periodical press and the Internet. Within the framework of the study, methods of statistical analysis and empirical research (comparison), general logical and analytical methods were used. Results. Using a five-year average method, the scale of excess mortality in Russia was calculated and evaluated, as well its determining factors during the pandemic were analyzed. The distribution of excess mortality by gender, age and place of residence was implemented. The factors of both direct and indirect effects of the coronavirus infection on the excess mortality rate in the country were identified. The pandemic has intensified manifestation of factors that had been determining the mortality dynamics in Russia for several years. Among the latter ones are noncommunicable diseases (primarily, cardiovascular diseases and cancer, which increase the risk of severe COVID-19, as well as those conditions that have deteriorated due to the delayed or postponed care delivery during the pandemic) and external causes of death (depression, alcohol poisoning and drug abuse).
IMPACT OF URBAN ECOLOGY ON THE HEALTH OF PRESCHOOL CHILDREN (BASED ON THE MONITORING STUDY RESULTS)
Authors:   Vologda Research Center of the Russian Academy of Sciences, Vologda, Russia, Razvarina I.N.
Published: January 2022

Significance. Characterizing industrial potential of the Vologda Region, it should be noted that it is mainly concentrated on metallurgical and chemical enterprises. In the course of their work, substances harmful to human health enter the environment. Emissions have a serious impact on the environment and human health. Taking into account significance of the study of risk factors for public health, the purpose of this study is to analyze the impact of unfavorable environmental conditions on the health of children aged 1 to 5 years living in cities of the regional importance (Vologda and Cherepovets). Material and Methods: The study used a sociological method. Prospective monitoring of observation of cohorts of families with children was used as a tool [1]. In the region (two cities: Vologda, the largest industrial center in the North-West of Russia and Cherepovets; regional centers of Veliky Ustyug, Kirillov and the urban-type settlement Vozhege) the study sample consisted of families with children born over a certain period of time. The monitoring involved families with children born in 1998, 2001 and 2004, 2014, 2020, however, the study also analyzed data of the ecologically unfavorable cities: Vologda and Cherepovets for 2015-2019. To assess health status of the preschool minors, the indicators of health groups were taken, which were determined in accordance with the Order of the Ministry of Health of the Russian Federation No. 514n as off August 10, 2017 "On the Procedure for conducting preventive medical examination of minors" [8]. Environmental conditions proposed for the assessment of the respondents included the following ones: water quality, purity of air, soil, remoteness from highways, lack of green spaces, outdoor playground for children [3]. In addition to sociological data, the information base of the study included research conducted by the Russian and foreign scientists in the field of health and healthy lifestyle, analytical materials of the World Health Organization (WHO), data of the Federal State Statistics Service and its Vologda territorial department, the medical information and analytical center of the Vologda region. The processing and analysis of the initial information was carried out using the Microsoft Office Excel software and SPSS software package. Results. Among other risk factors, polluted air, water, and soil within the territory where families with children live are the cause of disease development in preschool children in Vologda and Cherepovets.
ANALYSIS OF MORTALITY OF PATIENTS WITH DIABETES MELLITUS IN THE SAMARA REGION
Authors:   Samara City Polyclinic No.4 of the Kirovsky district, Samara, Russia, Pervyshin N.A. , Lebedeva I.V. ,   A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation, Moscow, Russia, Lebedeva E.A. ,   Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia, Galkin R.A. ,   Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia, Suslin S.A. ,   Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia
Published: January 2022

Significance: analysis of the mortality structure of patients with diabetes mellitus makes it possible to obtain information not only about the disease outcomes, but also to assess dynamics in epidemiological indicators of complications of diabetes mellitus, especially their terminal stages, which is one of the key effectiveness indicators of medical and rehabilitation measures. The purpose of the study: to conduct a dynamic analysis of the level and structure of mortality of patients with diabetes mellitus in the Samara region for the period from 2000 to 2017. Material and methods: the object of the study was a depersonalized database of the state register of diabetes mellitus in the Russian Federation and the Samara region and the death registration form of patients with diabetes mellitus of the annual report on diseases of the endocrine system. The mortality rates were calculated, the structure of mortality of patients with diabetes mellitus was analyzed according to the ICD-10 disease classes individually for diabetes mellitus type 1 and 2. Results: trends in the dynamics in mortality of patients with diabetes mellitus in the Samara region generally correspond to the Russian ones. Significant differences in the trends in mortality rates in patients with type 1 diabetes mellitus have been identified: the mortality rate in the Samara region increases against the background of the decreased indicator in the Russian Federation, and different vectors of the dynamics in mortality from atherosclerotic cardiovascular diseases are registered. Conclusion: the main reason for changes in the long-term decreasing trend in mortality from diabetes mellitus in the Samara region in 2010-2017 was changes introduced to the procedure for registering causes of death. When entering data into the state register of diabetes mellitus, if the cause of death is indicated as "diabetes mellitus", it is mandatory to indicate the direct cause of death. A limited list of basic mortality indicators of patients with diabetes mellitus is proposed, which can serve as indicators for the dynamic assessment of the epidemiological situation with complications of diabetes mellitus, as well as objective criteria for effectiveness of the ongoing medical and rehabilitation measures.
DYNAMICS IN TUBERCULOSIS INCIDENCE IN RUSSIA IN THE FIRST TWENTY YEARS OF THE XXI CENTURY
Authors:   Federal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian Federation, Moscow, Russia, Tsybikova E.B.
Published: January 2022

To assess progress in implementing the Program aimed at eliminating tuberculosis (TB) in Russia, the author has analyzed TB incidence in 2001-2020. The analysis results showed that in order to obtain reliable information, it is necessary to monitor not only the overall TB incidence, but also its structural components, such as the incidence of TB-HIV co-infection and the incidence of tuberculosis with multidrug resistance, that could have a negative impact on the prospects for reducing the overall TB incidence to the target values. Purpose: to analyze TB incidence in Russia in dynamics in 200120-20. Material and methods: information from the Federal statistical observation forms No. 8 and No. 33, as well as the Rosstat data on the Russian average annual population, for 2001-2020. Results: Over the past 20 years (2001-2020), there has been a steady decline in TB incidence in Russia; in 2020 the incidence rate equaled to 32.4 per 100,000 population. Such dynamics had a positive impact on the implementation of the TB Elimination Program in Russia, which has been fast progressing over the past 5 years. However, a widespread of TB-HIV co-infection registered in the last decade in a number of subjects of the Russian Federation, may have a negative impact on the dynamics in TB incidence in future, slowing down the rate of its decline, while the co-infection of HIV and multidrug-resistant tuberculosis can significantly increase the risk of death among patients with TB-HIV co-infection.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 15.01.2022 г. по 21.01.2022 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: January 2022

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с 15.01.2022 г. по 21.01.2022 г.
AIS data case study : evaluating reception of AIS position reports on the Missouri River by LOMA AIS sites in April and August 2020
Authors: Tetreault Brian , Kress Marin , DiJoseph Patricia
Published: January 2022

This Coastal and Hydraulics Engineering Technical Note (CHETN) describes a method for evaluating the received coverage from Automatic Identification System (AIS) shoreside sites along the Missouri River managed by the US Army Corps of Engineers (USACE) Lock Operations Management Application (LOMA), and presents the results of that analysis. The purpose is to identify AIS coverage gaps in the current system. Reception of AIS transmissions between shore-based transceivers and vessels is generally line-of-sight between the vessel and the AIS site antenna. However, signal reception may be affected by factors such as the distance and terrain between the vessel and the transceiver site, quality of the transceiver installation, state of the equipment either aboard the vessel or at the shore transceiver station, and atmospheric phenomena. Quantifying coverage gaps along the inland waterways system can inform research that uses AIS data, provide information on the performance of the AIS network, and provide guidance for efforts to address coverage gaps to improve navigation safety. In autumn 2020, severe shoaling was occurring on the Missouri River. As the shoals were identified, the Kansas City District requested the LOMA system transmit AIS Aid to Navigation (AtoN) to mark the shoals in several critical areas. However, vessel pilots sometimes reported that they were not receiving the AIS AtoN being transmitted. At the request of the Kansas City District, the US Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory (ERDC-CHL), conducted a coverage analysis using data collected from the LOMA AIS transceivers in the area to determine if there were coverage issues and their extent and to aid in determining the best means of addressing any coverage gaps.
Classification and Localization of Fracture-Hit Events in Low-Frequency Distributed Acoustic Sensing Strain Rate with Convolutional Neural Networks
Authors: Chen Mengyuan , Tang Jin , Zhu Ding , Hill Alfred
Published: January 2022

Distributed acoustic sensing (DAS) has been used in the oil and gas industry as an advanced technology for surveillance and diagnostics. Operators use DAS to monitor hydraulic fracturing activities, examine well stimulation efficacy, and estimate complex fracture system geometries. Particularly, low-frequency DAS can detect geomechanical events such as fracture hits because hydraulic fractures propagate and create strain rate variations in the rock. Analysis of DAS data today is mostly done post-job and subject to interpretation methods. However, the continuous and dense data stream generated live by DAS poses the opportunity for more efficient and accurate real-time data-driven analysis. The objective of this study is to develop a machine learning-based workflow that can identify and locate fracture-hit events in simulated strain rate responses correlated with low-frequency DAS data. In this paper, “fracture hit” refers to a hydraulic fracture originating from a stimulated well intersecting an offset well. We start with building a single fracture propagation model to produce strain rate patterns observed at a hypothetical monitoring well. This model is used to generate two sets of strain rate responses with one set containing fracture-hit events. The labeled synthetic data are then used to train a custom convolutional neural network (CNN) model for identifying the presence of fracture-hit events. The same model is trained again for locating the event with the output layer of the model replaced with linear units. We achieved near-perfect predictions for both event classification and localization. These promising results prove the feasibility of using CNN for real-time event detection from fiber-optic sensing data. Additionally, we use edge detection techniques to recognize fracture-hit event patterns in strain rate images. The fracture-hit location can be identified using recognized pixels in the image. The accuracy of edge detection-based location identification is also plausible, but edge detection is dependent on the assumption of pattern shape and image quality, hence it is less robust compared to CNN models. This comparison further supports the need for CNN applications in image-based real-time fiber-optic sensing event detection.
Analysis of the Risk of Complications During Pregnancy in Pregnant Women With Assisted Reproductive Technology: A Retrospective Study Using Registry Linkage From 2013 to 2018 in Shanghai, China.
Authors: He Mulan , Sun Xiaoxi , Wang Chunfang , Sui Yilun
Published: January 2022

Background: To evaluate the differences in pregnancy outcomes between assisted reproductive technology (ART) patients and natural pregnant women in Shanghai, China in the past 6 years objectively. And to assess the feasibility of the research method of registry-database linkage in mainland China. Methods: This retrospective study was conducted using registry-database linkage. A total of 8,102 pregnancies with ART and 8,096 parturients with spontaneous conception (SC) from 10 reproductive centers and 111 hospitals composed our retrospective study. The primary outcomes were the rates of obstetric complications (pregnancy-induced hypertention [PIH], gestational diabetes mellitus [GDM], placenta previa, mode of delivery, preterm birth [PTB], low birth weight [LBW], and macrosomia). The prenatal outcomes were compared between ART (n=8,102) and SC parturients (n=8,096), frozen-thawed embryo transfer (FET) (n=5513) and fresh embryo transfer (n=2589), and in vitro fertilization (IVF) (n=5144) and intracytoplasmic sperm injection (ICSI) (n=2958). We calculated odds ratios (ORs) and 95% confidence intervals (CIs). Results: The final matching rate of the target population was 92% by using registry linkage. ART resulted in a higher rate of multiple birth, PTB, LBW, cesarean section, placenta previa and GDM compared with SC in the singleton cohort. In ART patients, pregnant women with FET had a significantly higher risk of PIH than those with fresh embryo transfer (14.1% Vs 9.3%, AOR 1.526, 95% CI 1.300-1.790), but there was no difference between IVF and ICSI. FET is also related to the severity of PIH.Conclusions: ART increased the rate of complications during pregnancy, the risk and severity of PIH in patients with FET was higher than that in patients with fresh embryo transfer. The registry-database linkage study is an objective and feasible research method in mainland China.
Release Characteristics of Pb from Zn-Pb Mine Tailings Under Simulation Leaching Conditions
Authors: Akhavan Ahmad , Golchin Ahmad
Published: January 2022

In this paper, the results obtained from various leaching tests to determine the leaching behavior of lead from lead-zinc mine tailing under natural conditions were evaluated. In order to measure the level of toxicity of the tailings, synthetic precipitation leaching procedure (SPLP), toxicity characteristic leaching procedure (TCLP), leachate extraction procedure (LEP), and field leach test (FLT) protocols were used. The effect of liquid to solid ratio, particle size, contact time, and pH on lead release from tailings was also tested. Based on the results, the release of lead from the tailings was entirely affected by pH and amphoteric leaching behavior was observed. According to the results of the TCLP leaching protocol, the tailings categorized as hazardous material. Lead mobility index for S1 and S2 samples were 51% and 5.6%, respectively. The release of lead from the tailings was affected by the solubility process. The highest amount of lead release from S1 and S2 samples were observed in the particle size range of 0.3-0.5 mm and 0.6-1.0, mm respectively. According to the results, management of tailings and prevention of the release of lead into the environment, requires a special strategy. Controlling the amount of pore water, the size range of tailing particles in order to prevent wind erosion, prevent in situ pH changes, and acidification of tailings, and classification is essential factors in tailing management. In fact, health and diet security, climate change, safe water, accountable production, biodiversity, and ultimately the people must be considered in the planning of the authorities.
Automated Target-Driven Molecular Machine-Based Engineering Process For SARS-CoV-2 Monitoring
Authors: Fan Zhenqiang , Xie Minhao , Pan Jianbin , Zhang Kai
Published: January 2022

Nucleic acid structured electrochemiluminescence (ECL) biosensors provide valuable, versatile, programmable support for the development of medical diagnostics. Here, we constructed an automated DNA molecular machine with just one thiol-modified DNA probe and three nucleic acid probes on the surface of Ti3C2-based composites to monitor SARS-CoV-2, free from the limitations of motion tracks on the DNA molecular machine and significantly decreasing the probe modification fee. In the presence of the target, the designed DNA molecular machine conducted a modular reaction to transduce the target concentration information into an enhancement of the ECL signal based on DNA hybridization calculations. Modular, scalable reactions occur on DNA automata, reducing complex bioanalytical reactions to a single nucleic acid probe unit and eliminating the tedious steps of laying down motion tracks required by traditional molecular machines. By designing three capture probes, it is possible to extend the application ranges of the protocol from single to multi-target monitoring. Moreover, the strategy implements the bioanalysis of the SARS-CoV-2 in complex environments such as saliva dilutions and serum dilutions, which is valuable in promoting public health development and evaluating the environmental hazards of SARS-CoV-2.
Corneal Irregular Astigmatism And Visual Function On Anterior Segment Optical Coherence Tomography In TGFBI Corneal Dystrophy
Authors: Abe Yuito , Omoto Takashi , Kitamoto Kohdai , Toyono Tetsuya , Yoshida Junko , Asaoka Ryo , Yamagami Satoru , Miyai Takashi , Usui Tomohiko
Published: January 2022

The purpose of this study was to evaluate corneal irregular astigmatism of patients with granular and lattice corneal dystrophy (GCD and LCD). 70 GCD, 35 LCD, and 23 control eyes were included. Anterior and posterior corneal topographic data obtained from anterior segment optical coherence tomography were expanded into four components via Fourier harmonic analysis. These components were compared with healthy eyes and the association between each component and best-corrected visual acuity (BCVA) was investigated. Anterior and posterior components increased in LCD eyes, but none increased in GCD. Posterior components of GCD type 2 (GCD2), anterior and posterior of LCD type 1 (LCD1), posterior of LCD type IIIA (LCD 3A) and type IV (LCD4) significantly increased. BCVA was significantly associated with anterior and posterior components in LCD eyes but not in GCD. The anterior components of LCD1, anterior and posterior of LCD3A, and posterior of LCD4, but not the posterior of LCD3A, were positively correlated with BCVA. As conclusions, in GCD eyes, none of the components differed from those of the control and BCVA was not significantly associated with them. In LCD eyes, the anterior and posterior components increased, and BCVA was significantly associated with the anterior and posterior components.
Utilization of Freeze Thaw Process for Sodium Alginate and Polyvinyl Alcohol-Based Hydrogel Composite
Authors: Muangsri Rapeepan , Chuysinuan Piyachat , Thanyacharoen Thanyaluck , Techasakul Supanna , Ummartyotin Sarute
Published: January 2022

Abstract

Sodium alginate and poly vinyl alcohol-based hydrogel was successfully prepared by freeze thaw process. Without crosslinking agent, hydrogel was formed by using 3, 5 and 7 consecutive cycles of freeze thaw. Hydrogel can be formed by hydrogen bonding formation between OH-group of sodium alginate and poly vinyl alcohol throughout network. Scanning electron microscope reported that microstructure of hydrogel was well packed. The interconnect porosity was also observed. Differential scanning calorimetry exhibited that two exothermic peaks at temperature of 110ºC and 225ºC were observed due to evaporation of water molecule and melting temperature of hydrogel, respectively. The swelling behavior was rapidly increased within initial stage and then it was dimensionally stable. With low sodium alginate content, tensile strength was slightly superior, whereas low in vitro degradation behavior was observed. It was remarkable to note that sodium alginate and poly vinyl alcohol-based hydrogel exhibited outstanding properties for being as a medical material.
Comparison of Molecular and Morphological Identification of Ticks in Vellore District of Tamil Nadu
Authors: Saravanan Kalaimani , Aruliah Rajasekar , Prakash John A J , Kannan Kamarasu , Paramasivan Ramlingam , David Ernest
Published: January 2022

In this study, we have comparatively identified molecular and morphological features of ticks in Vellore district of Tamil Nadu. A total of 541 ticks were collected from domestic animals in the Vellore district of Tamil Nadu. The research was carried out between October 2018 and December 2019. The collected tick specimens were transferred into two sterile tubes and stored at room temperature in 70% alcohol. The tick was identified using PCR amplification of the 18SrRNA genes of Rhipicephalus sp (MW131877, MW318996, MW131878, MT952071) and Heamaphysalis sp (MW327046), the mtCOX1 gene of Rhipicephalus microplus (MT941478, MT941466, MT941463), and Hylomma marginatum (MW327046) (MW322564). The phylogenetic tree indicates that there was a common ancestor tick between Rhipicephalus sp., Heamaphysalis sp., and Hylomma marginatum in Vellore, Tamil Nadu. The tick was identified morphologically as two genera, Rhipicephalus sp. and Heamaphysalis sp. This is one of the first reports on ticks in the Vellore district of Tamil Nadu, as well as the morphological confirmation of two genera, Rhipicephalus and Heamaphisalis, through the sequencing of the 18SrRNA and mtCOX1 genes.
Presence and localization of apelin and its cognate receptor in the testis of the dog using immunohistochemical and molecular biology technique.
Authors: Troisi Alessandro , Dall'Aglio Cecilia , Maranesi Margherita , Orlandi Riccardo , Pastore Sara , Bazzano Marilena , Polisca Angela
Published: January 2022

Apelin, a member of the adipokine family, is a new endogenous peptide and it’s involved, by interacting with a specific receptor, in the control of human and laboratory animals’male reproduction. As far as we know, no data is available about the presence of the apelinergic system in dog testicles. Therefore the aim of this study was to show, for the first time, its presence and distribution in the canine testis by immunoistochemistry and molecular biology studies. For this purpose, five fertile and healthy male dogs were used and subjected to elective orchiectomy. The immunohistochemical reaction evidenced the presence of apelin and its receptor in the canine testis. In particular, apelin appeared localized in spermatids and spermatozoa with a positive signal in the “acrosomal bodies”. Regarding to the apelin receptor, a positive immunoreaction was evidenced in the cytoplasm of the cells localized in the basal portion of the seminiferous tubules, likely Sertoli’s cells, and in the cytoplasm of Leydig cells. The RT-PCR analysis showed the presence of transcripts for apelin and apelin receptor in all the samples examined. In conclusion our result allows us to hypothesize that the role of the paracrine and endocrine apelinergic system reported in laboratory animals can also be found in the dog.
Management of an Incompetent Mid-second (Mid-2nd) Trimester Absent Ectocervix: a Case Series. Cervical Amplification Pre-cerclage Insertion
Authors: Adedipe Tolu O , Akintunde Ade A , Chukwujama U.O
Published: January 2022

Cervical cerclage is a treatment for an incompetent cervix, the latter being a contributor to spontaneous preterm birth. There is significant difficulty with a transvaginal cerclage insertion for the absent vaginal or ecto-cervix in the mid-2nd trimester period resulting in a higher risk of late miscarriages, extremely preterm labour with subsequent neonatal morbidity and mortality. A retrospective review of cases managed by additional surgical techniques and protocols increased the likelihood of a successful insertion in this cohort of patients. This was supported by adjuvant post-operative management protocol which included vaginal progesterone use, regular infection screening and lifestyle advice.Cerclage insertion was mostly from 18- 20 weeks gestational age (GA) with an increased gestational latency of 13 gestational weeks (range 12-18) with all deliveries after 34 weeks GA. Mean gestational age at delivery was 36 weeks +1 (253 days) with a range of 241- 264 days in this small cohort of patients with minimal surgical complications and corresponding good neonatal outcomes.This technique has the potential to be a beneficial therapeutic option in management of an incompetent mid-2nd trimester absent ecto-cervix.