bluuebunny/crossref_metadata_2025 huggingface dataset:
Nationwide screening for Fabry disease in unselected stroke patients
Authors: Tomek Aleš , Petra Reková , Paulasová Schwabová Jaroslava , Olšerová Anna , Škorňa Miroslav , Nevšímalová Miroslava , Šimůnek Libor , Herzig Roman , Fafejtová Štěpánka , Mikulenka Petr , Táboříková Alena , Neumann Jiří , Brzezny Richard , Sobolová Helena , Bartoník Jan , Václavík Daniel , Vachová Marta , Bechyně Karel , Havlíková Hana , Prax Tomáš , Šaňák Daniel , Černíková Irena , Ondečková Iva , Procházka Petr , Rajner Jan , Škoda Miroslav , Novák Jan , Škoda Ondřej , Bar Michal , Mikulík Robert , Dostálová Gabriela , Linhart Aleš ,   on behalf of the National Stroke Research Network, part of Czech Clinical Research Infrastructure Network (CZECRIN) and Czech Neurological Society, Cerebrovascular Section
Published: December 2021

Background and aims

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by disease-associated variants in the alpha-galactosidase A gene (GLA). FD is a known cause of stroke in younger patients. There are limited data on prevalence of FD and stroke risk in unselected stroke patients.

Methods

A prospective nationwide study including 35 (78%) of all 45 stroke centers and all consecutive stroke patients admitted during three months. Clinical data were collected in the RES-Q database. FD was diagnosed using dried blood spots in a stepwise manner: in males—enzymatic activity, globotriaosylsphingosine (lyso-Gb3) quantification, if positive followed by GLA gene sequencing; and in females GLA sequencing followed by lyso-Gb3.

Results

986 consecutive patients (54% men, mean age 70 years) were included. Observed stroke type was ischemic 79%, transient ischemic attack (TIA) 14%, intracerebral hemorrhage (ICH) 7%, subarachnoid hemorrhage 1% and cerebral venous thrombosis 0.1%. Two (0.2%, 95% CI 0.02–0.7) patients had a pathogenic variant associated with the classical FD phenotype (c.1235_1236delCT and p.G325S). Another fourteen (1.4%, 95% CI 0.08–2.4) patients had a variant of GLA gene considered benign (9 with p.D313Y, one p.A143T, one p.R118C, one p.V199A, one p.R30K and one p.R38G). The index stroke in two carriers of disease-associated variant was ischemic lacunar. In 14 carriers of GLA gene variants 11 strokes were ischemic, two TIA, and one ICH. Patients with positive as compared to negative GLA gene screening were younger (mean 60±SD, min, max, vs 70±SD, min, max, P = 0.02), otherwise there were no differences in other baseline variables.

Conclusions

The prevalence of FD in unselected adult patients with acute stroke is 0.2%. Both patients who had a pathogenic GLA gene variant were younger than 50 years. Our results support FD screening in patients that had a stroke event before 50 years of age.
The distribution and reliability of TMS-evoked short- and long-latency afferent interactions
Authors: Toepp Stephen L. , Turco Claudia V. , Rehsi Ravjot S. , Nelson Aimee J.
Published: December 2021

Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) occur when the motor evoked potential (MEP) elicited by transcranial magnetic stimulation (TMS) is reduced by the delivery of a preceding peripheral nerve stimulus. The intra-individual variability in SAI and LAI is considerable, and the influence of sample demographics (e.g., age and biological sex) and testing context (e.g., time of day) is not clear. There are also no established normative values for these measures, and their reliability varies from study-to-study. To address these issues and facilitate the interpretation of SAI and LAI research, we pooled data from studies published by our lab between 2014 and 2020 and performed several retrospective analyses. Patterns in the depth of inhibition with respect to age, biological sex and time of testing were investigated, and the relative reliability of measurements from studies with repeated baseline SAI and LAI assessments was examined. Normative SAI and LAI values with respect to the mean and standard deviation were also calculated. Our data show no relationship between the depth of inhibition for SAI and LAI with either time of day or age. Further, there was no significant difference in SAI or LAI between males and females. Intra-class correlation coefficients (ICC) for repeated measurements of SAI and LAI ranged from moderate (ICC = 0.526) to strong (ICC = 0.881). The mean value of SAI was 0.71 ± 0.27 and the mean value of LAI was 0.61 ± 0.34. This retrospective study provides normative values, reliability estimates, and an exploration of demographic and testing influences on these measures as assessed in our lab. To further facilitate the interpretation of SAI and LAI data, similar studies should be performed by other labs that use these measures.
Evaluation of the efficacy of LAMP-based SARS-CoV-2 detection with simple RNA extraction from nasopharyngeal swabs: A prospective observational study
Authors: Karino Masaki , Harada Mizuki , Yamada Chihiro , Fukuoka Kyoko , Sugo Megumi , Hanada Hiroyuki , Masuda Daisaku , Adachi Shingo , Nakao Shota , Seki Masayuki , Yamato Masaya , Yamashita Shizuya , Takano Toru
Published: December 2021

The Loopamp SARS-CoV-2 Detection Kit is used for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Loop-mediated isothermal amplification (LAMP) is based on a measurement principle that can be used with a relatively simple device. Detection using this kit requires viral RNA extraction from samples with the QIAGEN QIAamp Viral Mini Kit (QIAGEN extraction) or the Loopamp Viral RNA Extraction Kit (Eiken extraction), which are recommended by the manufacturer. However, the efficacy of LAMP-based SARS-CoV-2 detection using these extraction methods has not been compared. In this study, we aimed to compare the results of genome extraction and detection from nasopharyngeal swab samples using the QIAGEN and Eiken extraction kits. The present study involved patients who presented to the Rinku General Medical Center with suspected COVID-19 (25 positive and 26 negative cases). A comparison of the results obtained using each extraction method with those obtained via PCR showed that the positive, negative, and overall concordance rates between QIAGEN extraction and PCR were 96.0% (24/25 samples), 100% (26/26), and 98.0% (50/51; κ = 0.96, 95% CI = 0.69–1.00), respectively. Results with Eiken extraction were also favorable, with positive, negative, and overall concordance rates of 88.0% (22/25), 100% (26/26), and 94.1% (48/51; κ = 0.88, 95% CI = 0.61–1.00), respectively. Favorable results were obtained using both QIAGEN and Eiken extraction kits. Since Eiken extraction can be completed in a few minutes, it enables prompt and reliable testing for SARS-CoV-2 detection.
Prevalence and clinical course of upper airway respiratory virus infection in critically ill patients with hematologic malignancies
Authors: Lee Jongmin , Kim Seok Chan , Rhee Chin Kook , Lee Jaewoong , Lee Jong Wook , Lee Dong-Gun
Published: December 2021

Background

The clinical significance of upper airway respiratory virus (RV) detection in patients with hematologic malignancies remains unclear. We aimed to investigate the association between upper airway RV detection and prognosis in critically ill patients with hematologic malignancies.

Methods

This retrospective observational study included 331 critically ill patients with hematologic malignancies who presented respiratory symptoms and their nasopharyngeal swab was tested using a multiplex PCR assay between January 2017 and December 2018. A logistic regression model was used to adjust for potential confounding factors in the association between assay positivity and in-hospital mortality.

Results

Among the 331 analyzed patients, RVs were detected in 29.0%. The overall mortality rates in the intensive care unit and hospital were 56.8% and 65.9%, respectively. Positive upper airway RV detection was associated with relapsed hematologic malignancies, higher level of C-reactive protein, and prior use of high dose steroids and anti-cancer chemotherapeutic drugs. Furthermore, it was independently associated with in-hospital mortality (adjusted odds ratio, 2.36; 95% confidence interval, 1.23 to 4.54). Among different RVs, parainfluenza virus was more prevalent among patients who died in the hospital than among those who survived (11.5% vs. 3.5%, P = 0.027).

Conclusions

RV detection in the upper respiratory tract was relatively common in our cohort and was significantly associated with a poor prognosis. Thus, it can be used as a predictor of prognosis. Moreover, RV presence in the upper respiratory tract should be examined in patients who have previously been prescribed with high dose corticosteroids and anti-cancer drugs.
Hybrid pointer networks for traveling salesman problems optimization
Authors: Stohy Ahmed , Abdelhakam Heba-Tullah , Ali Sayed , Elhenawy Mohammed , Hassan Abdallah A. , Masoud Mahmoud , Glaser Sebastien , Rakotonirainy Andry
Published: December 2021

In this work, we proposed a hybrid pointer network (HPN), an end-to-end deep reinforcement learning architecture is provided to tackle the travelling salesman problem (TSP). HPN builds upon graph pointer networks, an extension of pointer networks with an additional graph embedding layer. HPN combines the graph embedding layer with the transformer’s encoder to produce multiple embeddings for the feature context. We conducted extensive experimental work to compare HPN and Graph pointer network (GPN). For the sack of fairness, we used the same setting as proposed in GPN paper. The experimental results show that our network significantly outperforms the original graph pointer network for small and large-scale problems. For example, it reduced the cost for travelling salesman problems with 50 cities/nodes (TSP50) from 5.959 to 5.706 without utilizing 2opt. Moreover, we solved benchmark instances of variable sizes using HPN and GPN. The cost of the solutions and the testing times are compared using Linear mixed effect models. We found that our model yields statistically significant better solutions in terms of the total trip cost. We make our data, models, and code publicly available https://github.com/AhmedStohy/Hybrid-Pointer-Networks.
Minimum distance quantile regression for spatial autoregressive panel data models with fixed effects
Authors: Dai Xiaowen , Jin Libin
Published: December 2021

This paper considers the quantile regression model with individual fixed effects for spatial panel data. Efficient minimum distance quantile regression estimators based on instrumental variable (IV) method are proposed for parameter estimation. The proposed estimator is computational fast compared with the IV-FEQR estimator proposed by Dai et al. (2020). Asymptotic properties of the proposed estimators are also established. Simulations are conducted to study the performance of the proposed method. Finally, we illustrate our methodologies using a cigarettes demand data set.
Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis
Authors: Liu Xiaofang , Yang Guang , Luo Mengxin , Lan Qi , Shi Xiaoxia , Deng Haoyuan , Wang Ningning , Xu Xuezhu , Zhang Cong
Published: December 2021

Background

Vitamin E has long been linked to skin health, including all of its possible functions in cosmetic products, to its roles in membrane integrity and even the aging process. However, reports on the relationship between serum vitamin E levels and the risk of chronic inflammatory skin diseases have been inconsistent. We performed a systematic review and meta-analysis to evaluate the association between serum vitamin E levels and chronic inflammatory skin diseases.

Methods

We searched the PubMed, Web of Science and Scopus databases, with no time limit up to 30.06.2021. Studies examining serum vitamin E levels in patients with chronic inflammatory skin diseases were selected.

Results

Twenty articles met the inclusion criteria. Compared with controls, a lower vitamin E level was found in patients with vitiligo (SMD: -0.70, 95% CI: -1.21 to -0.19), psoriasis (SMD: -2.73, 95% CI: -3.57 to -1.18), atopic dermatitis (SMD: -1.08, 95% CI: -1.80 to -0.36) and acne (SMD: -0.67, 95% CI: -1.05 to -0.30).

Conclusions

Our meta-analysis showed that serum vitamin E levels were lower in patients suffering from vitiligo, psoriasis, atopic dermatitis and acne. This study highlights the need to evaluate vitamin E status to improve its level in patients with skin diseases.
Contact network analysis of Covid-19 in tourist areas——Based on 333 confirmed cases in China
Authors: Yang Zhangbo , Song Jingen , Gao Shanxing , Wang Hui , Du Yingfei , Lin Qiuyue
Published: December 2021

The spread of infectious diseases is highly related to the structure of human networks. Analyzing the contact network of patients can help clarify the path of virus transmission. Based on confirmed cases of COVID-19 in two major tourist provinces in southern China (Hainan and Yunnan), this study analyzed the epidemiological characteristics and dynamic contact network structure of patients in these two places. Results show that: (1) There are more female patients than males in these two districts and most are imported cases, with an average age of 45 years. Medical measures were given in less than 3 days after symptoms appeared. (2) The whole contact network of the two areas is disconnected. There are a small number of transmission chains in the network. The average values of degree centrality, betweenness centrality, and PageRank index are small. Few patients have a relatively high contact number. There is no superspreader in the network.
Health and well-being of university students before and during COVID-19 pandemic: A gender comparison
Authors: Gestsdottir Sunna , Gisladottir Thordis , Stefansdottir Runa , Johannsson Erlingur , Jakobsdottir Greta , Rognvaldsdottir Vaka
Published: December 2021

Objective

COVID-19 has affected people’s health in various ways. University students are a particularly sensitive group for mental and physical health issues. The aim of this study was to assess and compare the mental and physical health of male and female first-year university students during and before COVID-19.

Method

Total of 115 first-year university students (54% male) answered questions about mental and physical health. The students were asked to estimate their physical activity, sedentary behavior, loneliness, stress, and sleep quality during COVID-19 opposed to before the pandemic.

Result

Males had fewer symptoms of anxiety and depression, and their self-esteem was higher than females (p<0.05). Over 50% of both genders estimated their mental health to be worse than before COVID-19. Larger proportion of males (69%) compared to females (38%) estimated that their physical health had worsened than before the pandemic. Larger proportion of females (38%) than males (14%) experience increased loneliness and stress (68% vs. 48%). Over 70% of both genders estimated increased sedentary behavior than before the pandemic, and larger proportion of males (76%), compared to females (56%), estimated that they were less physically active than before COVID-19. About 50% of participants estimated their sleep quality was worse than before COVID-19.

Conclusion

University students estimated their mental and physical health to have deteriorated during the pandemic. Therefore, it is important that the school and healthcare systems assist students in unwinding these negative health and lifestyle changes that have accompanied the pandemic.
The development of the International Classification of Functioning, Disability and Health Core Sets for deafblindness: A study protocol
Authors: Paramasivam Abinethaa , Jaiswal Atul , Minhas Renu , Holzhey Peter , Keyes Karen , Lopez Ricard , Wittich Walter
Published: December 2021

Background

Individuals with deafblindness experience a combination of hearing and vision impairments. The World Health Organization has developed a global framework referred to as the International Classification of Functioning, Disability and Health (ICF) to describe health and functioning. From the full ICF classification, a selection of categories, referred to as ICF Core Sets, provide users with a tool to describe functioning and disability in specific health conditions. There has been no ICF Core Set created for deafblindness. Given that core sets are instrumental in improving clinical practice, research, and service delivery, the aim of this study is to develop an ICF Core Set for deafblindness.

Methods

As part of the preparatory phase in the ICF Core Set development, there are four studies that will be conducted. This includes the [1] systematic literature review that examines the researcher’s perspective, [2] qualitative study focusing on the individuals with deafblindness experience, [3] experts survey that looks at health professional’s perspective, and [4] empirical study that examines the clinical perspective. The studies will be conducted using the principles outlined by the ICF Research Branch for the development of ICF Core Sets. The systematic literature review protocol was submitted for registration on PROSPERO CRD42021247952.

Discussion

An ICF Core Set created for deafblindness will benefit individuals living with deafblindness who are often excluded from social participation, policies, and services. An ICF Core Set for deafblindness will have a significant impact on healthcare professionals, policymakers, researchers, service providers and individuals with deafblindness by facilitating communication among all stakeholder to support the functioning of those with deafblindness.
Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality
Authors: Ishaq Uzma , Malik Asmara , Malik Jahanzeb , Mehmood Asad , Qureshi Azhar , Laique Talha , Zaidi Syed Muhammad Jawad , Javaid Muhammad , Rana Abdul Sattar
Published: December 2021

Introduction

Coronavirus disease 2019 (COVID-19) is the ongoing pandemic with multitude of manifestations and association of ABO blood group in South-East Asian population needs to be explored.

Methods

It was a retrospective study of patients with COVID-19. Blood group A, B, O, and AB were identified in every participant, irrespective of their RH type and allotted groups 1, 2,3, and 4, respectively. Correlation between blood group and lab parameters was presented as histogram distributed among the four groups. Multivariate regression and logistic regression were used for inferential statistics.

Results

The cohort included 1067 patients: 521 (48.8%) participants had blood group O as the prevalent blood type. Overall, 10.6% COVID-19-related mortality was observed at our center. Mortality was 13.9% in blood group A, 9.5% in group B, 10% in group C, and 10.2% in AB blood group (p = 0.412). IL-6 was elevated in blood group A (median [IQR]: 23.6 [17.5,43.8]), Procalcitonin in blood group B (median [IQR]: 0.54 [0.3,0.7]), D-dimers and CRP in group AB (median [IQR]: 21.5 [9,34]; 24 [9,49], respectively). Regarding severity of COVID-19 disease, no statistical difference was seen between the blood groups. Alteration of the acute phase reactants was not positively associated with any specific blood type.

Conclusion

In conclusion, this investigation did not show significant association of blood groups with severity and of COVID-19 disease and COVID-19-associated mortality.
Reivindicações dos profissionais da informação
Authors: Miranda João
Published: December 2021

Os traços particulares do processo de profissionalização dos jornalistas colocam-nos perante desafios específicos, mas também perante modos singulares de confrontação desses problemas. Nas últimas quatro décadas, os jornalistas portugueses têm-se debatido com dilemas circunstanciais e sistémicos, que atravessam diferentes domínios da atividade. A partir da análise do conteúdo das resoluções finais, moções e relatórios-síntese dos quatro Congressos dos Jornalistas Portugueses (1982, 1986, 1998 e 2017), este estudo procura mapear as principais temáticas das reivindicações dos profissionais portugueses. Os resultados indiciam uma heterogeneidade nos assuntos que constituem as bandeiras de luta destes profissionais, envolvendo, nomeadamente, questões laborais, organização e controlo da profissão, ou a regulação da qualidade da informação.
Development of multiplex reverse transcription-polymerase chain reaction for differentiation of strains of infectious bursal disease virus and primary screening of the virus in Thailand
Authors: Charoenvisal Nataya
Published: December 2021

Background and Aim: A new set of primers (400 base pairs partial of VP2) was designed and used for the infectious bursal disease virus (IBDV) screening test. Using this new primer set, the enzymes MboI and BstNI were unable to differentiate the field and vaccine strains. As a result, a new simple, cheap, and appropriate tool for strain differentiation is required. The objective of this study was to develop the appropriate restriction fragment length polymorphism (RFLP) and multiplex reverse transcription-polymerase chain reaction (RT-PCR) for the differentiation of classic IBDV (cIBDV) strains and very virulent IBDV (vvIBDV) strains in Thailand.

Materials and Methods: Ninety seven bursa of Fabricius from 16 farms were collected from farms in the eastern and central regions of Thailand. RT-PCR screening showed that 82 samples were positive for IBDV and 15 samples were negative. Then, selected samples were sequenced from each farm with a positive test.

Results: The sequencing results showed that samples from six of the farms were vvIBDV and samples from the other six farms were cIBDV. Although the whole genome sequencing was incomplete, both the sequencing results of segment A and segment B showed high similarity between cIBDV and vvIBDV. Restriction enzyme cutting site and primers for multiplex RT-PCR were hard to design. An RT-PCR-RFLP method was developed, but it failed to differentiate IBDV strains. However, the multiplex RT-PCR was able to differentiate cIBDV from vvIBDV. Four primers were used in the multiplex RT-PCR.

Conclusion: These four primers were used together in one reaction at an annealing temperature of 45°C. Therefore, multiplex RT-PCR is a less complicated, cheaper, and less time-consuming method for the differentiation of cIBDV and vvIBDV strains.
A megbízható és objektív publikációs teljesítménymérés szükségessége A gazdálkodástudományok igénye a változásra és a tudomanymetria.com projekt
Authors: Krajcsák Zoltán , Szabó István
Published: December 2021

A tanulmány célja, hogy a tudományos közösségben a publikációs kiválóság értelmezési vitájában a gazdálkodástudományok vonatkozásában állást foglaljon a nemzetközi, minősített folyóiratcikkek kiemelt szerepe mellett. A szakterület fejlődéséhez, a nemzetközi kutatásokban való sikeres közreműködésekhez, az eredmények láthatóságának növeléséhez nélkülözhetetlen a nemzetközi folyóiratcikk-publikációk ösztönzése. Ezen túlmenően szakpolitikai igény, hogy elsősorban azok kapjanak finanszírozást, akik várhatóan előremozdítják a tudományt világszinten is. Az ösztönzés során figyelembe kell venni, hogy a teljesítményértékelési rendszerek sajátosságai önmagukban is mintául szolgálnak az egyéni publikációs stratégiák kialakításához. Amíg a habilitációs, egyetemi tanári, MTA doktori címek megszerzésének feltételeként előírt, nemzetközi folyóiratcikkekre vonatkozó szempontok csak jelképesen írják elő ezek teljesítését, addig egyre nagyobb a veszélye annak, hogy a hazai kutatók teljesítménye mindinkább elmarad a közép-európai átlagtól. A szerzők cikkükben bemutatják ennek egyik lehetséges ösztönzőjének, a tudomanymetria.com projektnek a szerepét a tudományterületi jellegzetességeket és kutatói életkort is figyelembe vevő publikációs kiválóság értékelésében, és ismertetik a közeljövőben történő, szakterületet érintő fontosabb változásokat is.
ALZHEIMER’S DISEASE, CEREBROVASCULAR DISEASE AND DEMENTIA: THEIR ASSOCIATION AND PREVENTION
Authors: Davey D.A.
Published: December 2021

Alzheimer’s disease (AD) and cerebrovascular disease (CVD) frequently co-exist and CVD acts additionally and synergistically with AD in ageing–related impairment of cognitive function and dementia. A significant number of men and women with normal cognition at the time of death have the neurodegenerative and cerebrovascular changes of AD and CVD and are regarded as having high cognitive reserve or cognitive resilience. Many measures used to prevent and treat cardiovascular disease, decrease the incidence, or delay the onset of ageing-related cognitive impairment and dementia. Ageing-related cognitive impairment and dementia are increased by adverse psycho-social factors and can be prevented or mitigated by appropriate psycho-social measures. There is now more than sufficient evidence to implement, as a matter of urgency, personal health and life-style measures and public health initiatives in the endeavor to prevent, postpone or ameliorate ageing-related cognitive impairment and dementia and to decrease its burden world-wide.
Entrevista com Jonas Capelli Jr
Authors: Martins Renato Parsekian , Zanardi Gustavo , Reis Sílvia Augusta Braga , Guedes Fabio , Capelli Jr. Jonas
Published: December 2021

Foi com imensa alegria que recebi o convite para coordenar a entrevista com o Dr. Jonas Capelli Junior. Impossível negar, no entanto, que com a satisfação veio também o peso da responsabilidade de falar sobre alguém que, mais do que colega de profissão, exemplo e professor, é um grande amigo. Aceitei sem titubear. Afinal, deve ser fácil escrever sobre alguém com tantos predicados. Como seu aluno e amigo há mais de 15 anos, posso dizer que o Dr. Jonas é o paulista mais carioca que conheço. Das ciclovias às quadras de tênis, passando pela cozinha, salas de aulas e consultórios, esse exímio ortodontista é inspiração para todos que com ele se relacionam. Na Ortodontia, ele contribui de forma enriquecedora em distintas frentes.
Seu software está enganando você: desafios digitais da Ortodontia
Authors: Bernd Guilherme
Published: December 2021

INTRODUÇÃO: A Ortodontia está cada vez mais digital, e a adaptação a essa realidade é necessária. Porém, a escolha das ferramentas digitais (softwares) que usamos para trabalhar pode influenciar nossos planejamentos e, até mesmo, o diagnóstico. O conhecimento de tais ferramentas digitais e de como elas funcionam é de suma importância na escolha do software que usaremos, e entender suas características e limitações pode influenciar nossos resultados. OBJETIVOS: A partir de um caso clínico, demonstraremos aspectos importantes de como os softwares interferem em nossas decisões e resultados. Assim, segmentação, algoritmos de movimentação, colisões digitais e deformação gengival são alguns dos importantes aspectos que devem ser analisados. CONCLUSÃO: Diferentes softwares podem trazer resultados divergentes quanto ao cálculo do número de alinhadores e outros aspectos. A tecnologia está evoluindo rapidamente nesse sentido, com aplicativos mais avançados e inteligência artificial aprimorada; porém, as sugestões realizadas por algoritmos de software não podem se sobrepor às decisões do ortodontista, quanto ao diagnóstico, estratégias de planejamento e condução clínica, a fim de se obter excelência nos resultados.
Tratamento de biprotrusão dentoalveolar em paciente com canino impactado associado a odontoma: relato de caso
Authors: Cunha Taís de Morais Alves da , Brandão Karla Magnólia Napoli , Barbosa Inêssa da Silva , Ferreira Vanessa Fernandes , Portugal Manuella Daltro , Amaral Carol Silva
Published: December 2021

NTRODUÇÃO: O tratamento da biprotrusão dentoalveolar frequentemente requer extrações dentárias, no intuito de diminuir a convexidade do perfil e permitir o selamento labial passivo. Nessas situações, o uso de ancoragem esquelética na mecânica de retração de dentes anteriores tem como principais vantagens a eliminação de efeitos colaterais indesejados e a diminuição da necessidade de colaboração dos pacientes, o que contribui para a eficiência do tratamento ortodôntico. OBJETIVO: Apresentar, por meio do relato de um caso clínico, os benefícios da ancoragem esquelética para a retração de dentes anteriores e a possibilidade de oclusão funcional com a extração unilateral de canino. DESCRIÇÃO DO CASO: Paciente Classe I de Angle com biprotrusão dentoalveolar, mordida aberta anterior e presença de canino superior impactado associado a odontoma, cujo tratamento foi conduzido com exodontias e utilização de mini-implantes como ancoragem. RESULTADO: Foi obtida oclusão mutuamente protegida, com função em grupo no lado em que o pré-molar substituiu o canino. Além disso, houve melhora significativa da estética dentofacial e do sorriso, com a colocação dos incisivos na inclinação adequada em suas bases ósseas. CONCLUSÃO: O uso da ancoragem esquelética permitiu fechamento de espaços, com adequado controle da inclinação dos dentes anteriores e da ancoragem posterior.
“Falha primária de erupção” existe?
Authors: Consolaro Alberto , Cardoso Mauricio de Almeida
Published: December 2021

INTRODUÇÃO: Não há como compreender onde haveria uma falha nos primórdios da odontogênese que pudesse ser chamada de “falha primária de erupção”. OBJETIVO: Uma análise bem fundamentada desse “diagnóstico” é o objetivo do presente artigo. DISCUSSÃO: A ossificação e o desenvolvimento dos germes dentários geram forças que expandem seu volume em todas as direções. Os dentes em formação tendem a se direcionar para o plano oclusal e a formar o processo alveolar, por apresentarem mais mediadores do tipo EGF nos seus espaços e tecidos pericoronários do que nas demais regiões. Os dentes com “falha primária de erupção” quase sempre têm anquilose e reabsorção dentária por substituição que não foram diagnosticadas, por serem usadas radiografias panorâmicas. Com as radiografias periapicais e tomografias, a causa local quase sempre é identificada. O histórico do paciente também é muito importante nessa identificação. CONCLUSÃO: Não existiria uma “falha primária de erupção”, mas se, após excluídas todas as causas, tender-se a usar esse termo, o mais adequado seria substituí-lo por “falha idiopática de erupção”, pois não se conseguiu identificar a causa localmente, mas ela existe, ou existiu, e não conseguimos descobri-la.
Left Ventricular Ballooning Patterns in Recurrent Takotsubo Cardiomyopathy: A Systematic Review and Meta-analysis of Reported Cases
Authors: Korabathina Ravi , Porcadas Jamie , Kip Kevin E. , Korabathina Puja R. , Rosenthal Andrew D. , Wassmer Peter
Published: December 2021

Recurrent takotsubo cardiomyopathy (TTC) and the clinical profiles and outcomes of patients have not been fully evaluated, nor has the effect of left ventricular ballooning pattern. After searching the medical literature for reports of patients with recurrent TTC, we identified 84 articles with 101 case descriptions. We divided the cases into those with only apical left ventricular ballooning patterns at recurrence (typical, n=60), and those with at least one midventricular or basal ballooning pattern (atypical, n=41). We then compared their clinical profiles and outcomes.

The groups were similar in terms of baseline demographic characteristics, presence and types of triggers, use of heart failure medications at TTC recurrence, electrocardiographic changes at presentation, initial left ventricular ejection fractions, timespans between recurrent TTC episodes, and recovery times after each event. However, patients in the atypical group had significantly fewer severe adverse events (cardiogenic shock and cardiac arrest) than did those in the typical group, with an estimated 63% lower odds (adjusted odds ratio=0.37; 95% CI, 0.14–0.97; P=0.039). Survival to hospital discharge was statistically similar but lower in the typical group (n=53; 88.3%) than in the atypical group (n=24; 96%).

Our results suggest that left ventricular ballooning patterns influence clinical outcomes, and that outcomes are more favorable in patients with recurrent TTC who have atypical left ventricular ballooning patterns.
Endovascular Treatment of Acquired Atheromatous Postsubclavian Aortic Coarctation
Authors: Sonawane Bhushan S. , Pavithran Sreeja , Sivakumar Kothandam
Published: December 2021

Coral reef aorta is a rare calcifying obstructive disease that involves the thoracoabdominal aorta. Similar presentations in the postsubclavian aorta may result in acquired atheromatous aortic coarctation leading to systemic hypertension and heart failure. The associated calcification makes surgical anatomic or extraanatomic bypass and thromboendarterectomy challenging. Extensive circumferential calcification often precludes endovascular intervention. We present the case of a 25-year-old man with an acquired atheromatous coarctation of the postsubclavian aorta who underwent successful endovascular treatment with use of a balloon-expandable covered stent.
SPECIFICS OF GRADUAL TRANSITION TO POST-EMERGENCY PARAMETERS FOR STATIC STABILITY TESTING OF DISTRIBUTED GENERATION FACILITIES
Authors:   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russian Federation, Gazizova O.
Published: December 2021

Design and operation of distributed generation facilities needs to provide for sufficient margin of static sta-bility in a variety of operating situations, including normal and post-emergency operation in parallel with the outer grid (the power system). Power system protections are often placed where the on-site power plants connect to the power system; these protections enable the loaded generators to become islanded in case of emergency; rated margin of static stability must be available in such post-emergency operation. To analyze static stability of synchronous generators and motor loads, we propose combining gradual equalization and gradual tran-sition to post-emergency parameters. However, the latter method has different quirks when applied to static stabi-lity testing of generators, depending on whether they are running in parallel or islanded. Besides, application of this method requires multiple constraints pertaining to the functioning of on-site power plants, among other things. The authors hereof have developed a single algorithm for static stability testing of generators and loads that applies well to on-site power plants whether they are islanded on running in parallel to the grid. The algorithm adjusts for constraints on excitation systems and is implemented in KATRAN software. A computational experiment is described herein that concerns an electricity delivery system that is powered by distributed generation facilities and carries heterogeneous motor loads. Specific features of such studies are additionally described.
COMPARATIVE ANALYSIS OF PRESSURE PULSATIONS CAUSED BY SPIRAL-VORTEX STRUCTURES IN THE FLOW PART OF THE HYDRAULIC TURBINE MODEL
Authors:   Novosibirsk State University, Novosibirsk, Russian Federation, Suslov D. , Litvinov I. , Gorelikov E. ,   Kutateladze Institute of Thermophysics, Siberian Branch of the RAS,  Novosibirsk, Russian Federation
Published: December 2021

The paper studies the pressure pulsations in the hydraulic turbines flow section arise as a result of vortex structures in non-optimal hydraulic turbine operation regimes. The authors directly compare the approaches to the extraction of synchronous and asynchronous components in pressure pulsation signals, as well as using the decomposition into azimuthal modes. Pressure pulsations were measured using four acoustic sensors while varying the operating regimes of the hydraulic turbine model. The pressure pulsations were compared for the shallow draft tube and the deep draft tube of the hydraulic turbine. It is shown that the level of pressure pul-sations is the same for two types of draft tubes. There is no methodological difference in the application of the two approaches to the extraction of pressure pulsations in the flow. The results shall be applicable in the de-velopment of new methods for suppressing spiral-vortex structures in non-optimal regimes of operation of hydraulic turbines in order to increase their overall efficiency.
MULTIVARIABLE CONTROL OF SOLAR BATTERY POWER: ELECTROTECHNICAL COMPLEX AS OBJECT WITH HESSIAN-DRIVEN GRADIENT FLOWS
Authors:   South Ural State University, Chelyabinsk, Russian Federation, Sologubov A. , Kirpichnikova I.
Published: December 2021

The paper presents certain development results for the novel extremum seeking controller based on Nesterov’s gradient flows for solar tracking systems. It achieves convergence to an arbitrarily small neighborhood of the set of the cost function optimizers. Our results evident ate that for arbitrarily large compact sets of initial conditions, and arbitrarily small neighborhoods of the optimizer, the controller can be tuned to guarantee convergence taking into account the influence of the Hessian, as well as with tuning parameters that have a fairly clear physical meaning. The influence of the Hessian as a vector field, which is a reflection of the distortion of transient processes in the system, and taking it into account is an urgent task, since it allows for a more flexible impact on the speed of transient processes, and by endowing the system with some damping and smoothing, also for its improved quality.
Czas, który wypadł z ram. Antropocen i ekokrytyczna lektura tekstów literackich
Authors: Szaj Patryk
Published: December 2021

Pierwsza część artykułu podejmuje teoretyczny namysł nad antropocenem jako epoką, w której nastąpiło radykalne wymieszanie czasu ludzkiego i geologicznego. W części tej przedstawione są wglądy formułowane w obrębie dyskursu antropocenu, a także ustalenia klimatologii. Skłaniają one do wypracowania widmontologii antropocenu jako epoki, w której „czas wypadł z ram”. Druga część artykułu przekłada ustalenia teoretyczne na praktykę literaturoznawczą (zwłaszcza ekokrytyczną). Autor rekonstruuje propozycje uprawiania ekokrytyki w czasach antropocenu sformułowane przez Timothy’ego Clarka oraz Lynn Keller i podejmuje wstępne próby przełożenia ich na kontekst literatury polskiej.
Brudna transcendencja. Rudymenty sacrum a przemiany współczesnych ekopoetyk
Authors: Soćko Joanna
Published: December 2021

Wychodząc od lektury kilku – pochodzących z końca XX w. – wierszy odnoszących się do przyrody, autorka redefiniuje tradycyjnie rozumianą transcendencję i immanencję, osadzając te kategorie w kontekście studiów postsekularnych i szeroko rozumianego nowego materializmu. Główną tezę artykułu stanowi bowiem przekonanie, że przedstawione przeformułowanie tych kategorii pozwala w ciekawy sposób przedstawić dynamikę zmian ekopoetyk charakterystycznych dla XX i XXI wieku. Omawiając wybrane przykłady poezji twórców odznaczających się wyjątkową świadomością nieprzejrzystości języka, autorka zwraca uwagę na istotną cezurę, jaką okazała się debata wokół pojęcia antropocenu i omawia obecne tendencje poetyckie, uwzględniające implikowany przez to pojęcie światopogląd.
„Za mało na ślad”. O Spisie z natury i innych wczesnych wierszach Krystyny Miłobędzkiej
Authors: Bogalecki Piotr
Published: December 2021

Artykuł stanowi próbę rekonstrukcji poetyki wczesnych tekstów Krystyny Miłobędzkiej. Głównym przedmiotem zamieszczonych w nim analiz jest tom Spis z natury, powstający w pierwszej połowie lat sześćdziesiątych XX wieku jako poetycki debiut, lecz wówczas nieopublikowany. Podejmując łączną lekturę dwóch składających się na niego cykli poetyckich – Anaglifów i Małych mitów – autor wskazuje na konieczność uzupełnienia nasuwającego się w lekturze tego pierwszego odczytania nieantropocentrycznego o implikowaną przez wielopoziomową strukturę tego drugiego interpretację postsekularną. Analizie poddano również cztery wiersze Miłobędzkiej – Małże, Widziane w ogniu, Patrzące chwytliwe oraz Klee – opublikowane w latach sześćdziesiątych w miesięczniku „Twórczość” i niewłączone w żaden jej tom. Pozwoliło to wskazać na możliwe związki wczesnej poezji autorki Wykazu treści z twórczością Francisa Ponge’a i Paula Klee.
Do źródeł, do gór. Protoekokrytyczne odczytania Waldenu Henry’ego Davida Thoreau i Na przełęczy Stanisława Ignacego Witkiewicza
Authors: Budnik Agnieszka
Published: December 2021

Artykuł przedstawia komparatystyczne ujęcie obrazów przyrody w literaturze przełomu XIX i XX wieku na przykładzieWaldenu, czyli życia w lesie Henry’ego Davida Thoreau oraz Na przełęczy Stanisława Witkiewicza. Punktem wyjścia do rozważań o początkach literatury środowiskowo zorientowanej jest lektura eseju D.H. Thoreau. W założycielskim dla gatunku przyrodopisarstwa tekście Amerykanina upatruje się również korzeni współczesnych badań ekokrytycznych: łączących w sobie postawę aktywistyczną i rewizyjną wobec relacji człowieka i pozaludzkiej przyrody. Choć przyrodopisarstwo nie wykształciło swojej tradycji na gruncie polskiego literaturoznawstwa, lektura Na przełęczy Stanisława Witkiewicza aż nadto zdaje się odpowiadać typologii tekstów zorientowanych środowiskowo, wypracowanej na podstawie eseju H.D. Thoreau przez Lawrence’a Buella.
Determinanty kredytu kupieckiego w Polsce w świetle wyników analizy danych panelowych – czynniki zróżnicowania wewnątrz i międzyobiektowego
Authors: Wiśniewski Marcin , Wiśniewska Dorota , Becella Adrian
Published: December 2021

Kredyt kupiecki stanowi istotny, chociaż, jak się wydaje, najmniej zbadany sposób finansowania przedsiębiorstw w Polsce. W niniejszym artykule autorzy analizują, jakie czynniki określają wybór kredytu kupieckiego przez przedsiębiorstwa w Polsce – jako źródła finansowania oraz sposobu tworzenia należności, a także diagnozują istnienie tzw. efektów indywidualnych, które różnicują poszczególne przedsiębiorstwa pod względem ogólnej skali zastosowania kredytu kupieckiego. Przeprowadzone przez autorów i opisane w tym artykule badania wskazują na zależność tych efektów za branży i struktury aktywów.
Ochrona autonomii człowieka w ramach wybranych gwarancji dotyczących wolności
Authors: Wojcieszak Agnieszka
Published: December 2021

Niniejszy artykuł w syntetyczny sposób prezentuje kwestie ochrony autonomii człowieka w ramach niektórych gwarancji dotyczących wolności. Rozważania podjęte przez autorkę koncentrują się wokół w pierwszej kolejności wokół ustalenia, czym jest wolność. Następnie poddano analizie problematykę ochrony autonomii człowieka z perspektywy obecnych rozwiązań legislacyjnych gwarantujących ochronę wolności, w szczególności przepisów konstytucyjnych, przepisów prawa cywilnego, a także niektórych spośród przepisów regulujących stosunki prawnomedyczne. Celem niniejszego artykułu jest bowiem zaprezentowanie, z jednej strony relacji istniejącej pomiędzy wolnością a autonomią, z drugiej zaś - ustalenie czy obecne przepisy gwarantują właściwą ochronę wolności, a w następstwie również autonomii.
On the forms of accretion of interstellar gas and dust during the formation of single stars and their planetary systems
Authors: Abdulmyanov Tagir
Published: December 2021

In this paper, the mechanisms of star formation and the formation of the equatorial gas and dust disk of protostars are considered. The viscous dynamics of the interstellar matter of gas and dust disks is mainly determined by perturbations of the matter density during gas accretion onto the equilibrium core of the protostar. Using the model of pulsating perturbations of the density of the gas-dust envelope of the protostar and the Navier-Stokes equations, the formulas for the dynamic viscosity of Keplerian and almost Keplerian disks are obtained. It is shown that in the regime of unstable equilibrium of the envelope, accretion of gas onto the core of the protostar begins. In the regime of stable equilibrium, the fragmentation of the gas-dust envelope and the equatorial disk of the protostar occurs. In the ring-shaped fragments of the disk, the process of formation of “embryos” of planets begins and accretion on the “embryos” of the planet also begins.
Typologizing nominal expressions: the noun phrase and beyond
Authors: Louagie Dana , Reinöhl Uta
Published: December 2021

This article develops foundations for a new typology of nominal expressions. Despite the significant diversity attested in languages around the world, a view traditionally and sometimes still found holds that languages either have ‘classic’, rigidly structured noun phrases (NPs) or lack them. A simple dichotomy, however, does not adequately represent the significant language-internal and crosslinguistic diversity of forms and functions of nominal expressions. While many linguists may not in fact think in such binary terms, a comprehensive typology is still wanting. This article offers foundations towards such a typology, with a particular emphasis on language-internal diversity. This diversity within languages has received little attention in previous studies, even while it reveals much about the actual complexity in the nominal domain. Besides surveying structural types and their motivating factors across as well as within languages from around the world, this article approaches nominal expressions also from a variety of other perspectives to enrich our understanding of them. This includes approaching nominal expressions from the perspective of word class systems as well as diachronically. We round off the article by looking at the impact of orality-literacy dimensions and communicative modes.
Corrosion behavior of particle reinforced aluminum composites
Authors: Karabulut Hasan , Karacif Kubilay , Çıtak Ramazan , Çinici Hanifi
Published: December 2021

In the study, the corrosion behavior of aluminum matrix composites reinforced with boron carbide (B4C), silicon carbide (SiC) and alumina (Al2O3) were investigated in saltwater (3.5 % NaCl). Composite materials were produced by powder metallurgy. For composite materials production, various reinforcement and aluminum powders were mixed by mechanical alloying for 4 and 10 hours. After mechanical alloying, mixed powders were compacted under 700 MPa pressure and sintered at 600 °C. Electrochemical corrosion tests were applied on specimens in the saltwater solution using potentiodynamic methods. According to the results of the investigation, the best corrosion resistance was obtained by aluminum/B4C and the lowest by aluminum/Al2O3 composites.
Effect of steel forming on vehicle side impact behavior
Authors: Doruk Emre
Published: December 2021

Despite the seemingly daily development of high-strength new generation steel sheets, steel sheets still remain the most important engineering material used in a vehicle body. These steel parts in a vehicle body, meant to absorb energy during impact, are generally produced by steel forming methods. These steel forming operations may contain processes such as deep drawing, bending, cutting, spring back, spinning. According to the production conditions and type of processes used during the production of sheet metal parts, thinning, thickening, plastic deformation, folding, tearing and wrinkling may occur. In order to achieve more reliable impact simulations, these effects in the forming process should be conferred on impact analysis. Within the scope of this study, an analysis of the critical parts in steel forming that absorb the most energy during the side impact was conducted – first for vehicles. In a subsequent impact analysis, the effects of changes (thickness distribution, residual stress, plastic deformation, etc.) during steel forming were examined.