bluuebunny/crossref_metadata_2025 huggingface dataset:
Trataka: A Promising Intervention to Reduce Anxiety in Children? A Randomized Controlled Trial with Cognitive and Electrodermal Measures
Authors: Pandya Parth Rajesh
Published: December 2024

Background:

One in five children suffers crippling dental anxiety, and traditional calming methods often fall short. Trataka, an ancient yogic technique, offers a powerful new approach to manage this anxiety.

Objective:

The objective is to investigate whether Trataka practice is more effective than relaxation techniques in reducing anxiety in children undergoing dental procedures.

Methodology:

A two-arm, parallel-group, randomized controlled trial was conducted with 120 children aged 8–11 years requiring local anesthesia for dental procedures. Participants were randomized to either a Trataka group (n = 60) or a relaxation techniques group (n = 60). Both groups received 4 weeks of training on their assigned intervention. The primary outcome was anxiety level measured by the Mood and Anxiety Symptom Questionnaire (MASQ) administered pre- and postintervention. Secondary outcomes included electro-dermal activity (EDA) test results and the Stroop Colour Word Test (SCWT), both performed pre- and postintervention, and observed anxiety-related behaviors during procedures.

Results:

Children in the Trataka group exhibited a significantly greater reduction in anxiety compared to the relaxation techniques group, as measured by the MASQ score (P < 0.001) and lower EDA response during the SCWT (P < 0.01). The Trataka group also displayed fewer observed anxiety-related behaviors during procedures (P < 0.001).

Conclusions:

The findings suggest that Trataka may be more effective than relaxation techniques in reducing anxiety in children undergoing dental procedures.
Yoga Therapy Attenuates the Progression of Diabetes – Insights from Proteomics and Metabolomics Analysis
Authors: Sonwane Babasaheb P. , Raut Pooja , Chitalkar Jyotsna , Godbole Smita , Sabnis Shanta , Gupta Jyoti , Santhakumari B. , Deshpande Mukund V. , Kulkarni Mahesh J.
Published: December 2024

Objective:

Diabetes management remains challenging despite advancements in therapeutics, with many subjects developing complications. Yoga has been shown to aid diabetes management. This study investigates the impact of yoga therapy on diabetes progression, utilizing proteomics and metabolomics analyses to explore underlying molecular mechanisms.

Methodology:

A 3-month longitudinal study involving healthy subjects with prediabetes and diabetes was conducted. Blood glucose, glycated hemoglobin (HbA1c), lipid profile, and malondialdehyde (MDA) levels were measured before and after the yoga intervention.

Results and Conclusion:

Healthy subjects showed no significant changes in blood glucose, lipid profile, HbA1c, or MDA levels. However, subjects with prediabetes and diabetes experienced positive changes, with decreases in HbA1c and MDA levels. Proteomics and metabolomics analyses provided insights into the molecular mechanisms by which yoga attenuates diabetes progression in subjects with prediabetes and diabetes. This study is a pioneering effort to understand the molecular basis of yoga’s beneficial effects on diabetes management.
Assessment of the Diagnostic and Prognostic Values of CD200 and CD43 in CLL and Leukemic Phase of NHL
Authors: Al-Khafaji Teeb M. Jaafar , Rashid Ahmed Ibraheem
Published: December 2024

BACKGROUND:

Chronic lymphoproliferative disorders (LPDs), such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), are comprised heterogeneous malignant hematopoietic clinicopathologic syndromes with broad clinical features. Molecular diagnostic procedures such as immunophenotyping and cytogenetics have improved the accuracy of diagnosis in recent years. While CLL and NHL were previously indistinguishable based on clinical or immunophenotypic parameters, new biomarkers such as CD200 and CD43 have facilitated separation from one another allowing for prognostication in these hematological disorders.

AIM OF STUDY:

To evaluate the diagnostic and prognostic significance of CD200 and CD43 expression in CLL and the leukemic phase of NHL.

SUBJECTS AND METHODS:

The patients studied were 145 who have chronic lymphoproliferative disorders that attended the Baghdad Teaching Hospital at Medical City from (January 1, 2020, to December 31, 2020; they were divided into CLL and NHL groups observed in this cross-sectional study. CD200 and CD43 were assessed as baseline. Clinical and laboratory results were collected, combining CLL staging with the Ann Arbor method and NHL staging with the modified Rai system, respectively.

RESULTS:

CD200 and CD43 were found to have a significant correlation in distinguishing between CLL and NHL. Most CD200-positive patients have moderate to extreme levels of CLL expression, whereas NHL patients generally have dim- or moderate-positive expression patterns. CD43 expression is also dim to moderate in most cases in CLL and few NHL cases.

CONCLUSIONS:

This study shows CD200 and CD43 useful in distinguishing CLL from NHL in leukemic phase. These two markers have the highest co-expression in CLL relative to NHL, which suggests their combination might significantly improve diagnostic power.
Evaluating the Impact of Lenalidomide on Bone Marrow Cancer Treatment: Monitoring White Blood Cell, Hemoglobin, and Platelet Levels
Authors: Hussein Hiba Jumaa , Nazar Lara Ali , Ghazi Hamsa Ghwamer
Published: December 2024

BACKGROUND:

Lenalidomide (LEN), also known as Revlimid, is a drug used to treat multiple myeloma (MM), smoldering myeloma, and myelodysplastic syndromes. It is used as a first-line treatment for MM, along with dexamethasone.

OBJECTIVE:

To investigate the effects of LEN on the function of bone marrow (BM) by monitoring the changes in the number of white blood cells (WBCs), hemoglobin levels, and platelet counts in people who were getting treatment.

MATERIALS AND METHODS:

Includes 90 blood samples from 30 cancer patients before treatment and 30 cancer patients after treatment and 30 healthy individuals aged 60–75 years and is conducted at City Medical Hospital. The blood samples are analyzed to detect Erythrocyte Sedimentation Rate (ESR) by using an ESR fast detector, and detect WBC, red blood cell, and platelets by Mindray CBC-21S. Tests are performed weekly initially, and then biweekly or monthly, taking into account ethical issues such as obtaining consent and criteria for adjusting treatment based on side effects or changes in blood counts.

RESULTS:

The findings revealed a notable change in the amount of WBCs at the start of the study. These cells significantly decreased and then level off a few months after treatment (2–5) months. Before and after medication, the levels of hemoglobin were changing. The results also showed that the number of platelets in some cases dropped by a large amount.

CONCLUSION:

Adding LEN could help patients with BM cancer since it reduces microvascularization and most likely increases the particular T cell-driven anti-leukemic response.
Enhancing Venous Thromboembolism Risk Prediction through Novel Biomarkers and Inflammatory Indicators
Authors: Al-Maaroof Zainab Wahab
Published: December 2024

BACKGROUND:

Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism, is a common disease and considerable cause of morbidity and mortality worldwide, especially among hospitalized or postoperative patients. However, the prediction accuracy calculated with the help of traditional methods (including Wells score and D-dimer tests) is not so ideal to predict this risk of disease; therefore, novel biomarkers need to be explored. This study aims to evaluate the potential of new biomarkers, such as thrombin generation, microRNAs (miRNAs), Factor VIII, and inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6), to enhance the prediction of VTE risk, thereby facilitating earlier and more precise interventions.

SUBJECTS AND METHODS:

A case–control study in care hospital enrolled 500 participants, including 250 with confirmed VTE and 250 controls without complications. Participants aged 18 years or older who had not received anticoagulant treatment before the start of the trial exclusion criterion included current infection, pregnancy, and hematological disorders. Plasma was collected for biomarker analysis in the following: D-dimer, thrombin generation, factor VIII levels, and inflammatory markers using enzyme-linked immunosorbent assay (ELISA) (CRP/IL-6/miRNAs), CAT, and real-time polymerase chain reaction.

RESULTS:

The current study revealed that D-dimer levels were much higher in VTE patients compared with controls while Thrombin generation time decreased in VTE patients, miRNAs miR-145 and miR-223 are highly expressed in those patients. Factor VIII and inflammatory markers were significantly elevated in patients compared with the control group.

CONCLUSION:

The study highlights the importance of novel biomarkers such as thrombin generation time, factor VIII levels, circulating miRNAs, and inflammatory markers in assessing VTE risk. These biomarkers may be able to identify people at a greater risk, which could lead to more personalized medical interventions for high-risk populations. The finding underlines the importance of integrating these biomarkers into clinical guidelines for risk prediction and prevention compared to patients without these conditions.
Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child
Authors: Mardewi I Gusti Ayu , Lestari Anak Agung Wiradewi , Wande I Nyoman , Mahartini Ni Nyoman
Published: December 2024

Mixed-phenotype acute leukemia (MPAL) is characterized by the expression of markers from multiple hematopoietic lineages, including myeloid, B-cell, and T-cell origins. This case report describes a 3-year, 8-month-old girl who presented with swelling in both eyes, initially accompanied by lumps on the neck and a fever that subsided with antipyretics. After the neck lumps resolved, eye swelling began in the right eye and later progressed to the left eye. Bone marrow aspiration confirmed the presence of mixed-lineage leukemia, revealing myeloblasts with Auer rod, monoblast, and lymphoblast. Leukemia phenotyping identified a mixed lineage involving myeloid, B-cell, and T-cell markers, supporting the diagnosis of MPAL. The patient was treated according to the acute lymphoblastic leukemia induction therapy protocol with vincristine and daunorubicin, and fluid hydration and allopurinol were taken to prevent tumor lysis syndrome. This case highlights the diagnostic complexity and need for a comprehensive treatment approach in managing MPAL.
A Rare Case of Superior Mesenteric Artery Thrombosis in Multiple Myeloma
Authors: Singh Jasminder , Yadav Kusum , Kaushik Ankush , Babu Irshad
Published: December 2024

Superior mesenteric artery (SMA) thrombosis is a life-threatening illness which results in bowel ischemia due to compromised blood supply to small bowel along with proximal colon. A 60-year-old male presented with symptoms of dull aching diffuse type of abdominal pain associated with vomiting, diarrhea, and fever. His clinical examination was unremarkable. His hemoglobin levels were low with markedly raised erythrocyte sedimentation rate and alkaline phosphatase levels. On diagnostic evaluation, he was found to have multiple myeloma with SMA thrombosis associated with bowel ischemia and sepsis. This case report emphasizes the importance to rule out the possibility of plasma cell dyscrasias in elderly patients presenting with clinical features of mesenteric artery thrombosis.
Association between microRNA 92a-3p and GATA3 Levels in Packed Red Blood Unit with Storage Time in Blood Banks
Authors: Obeidat Nour , Fararjeh Abdulfattah , Al-Sanabrah Ola
Published: December 2024

BACKGROUND:

The concentration of microRNAs (miRNAs), which are the negative regulators of cellular mRNAs, is higher in mature red blood cells (RBCs) than in other blood cell types. Age-related storage abnormalities are more prevalent in human-packed RBCs (PRBCs) but less is known about how miRNAs affect inflammation in humans after transfusion.

MATERIALS AND METHODS:

Four different blood bags containing the blood of four healthy donors were used to collect samples. Total ribonucleic acid (RNA) was isolated from the units at 0, 14, 21, and 28 days following storage. The expression of GATA3 was assessed using the Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). To find the expression of miRNAs, the Illumina platform employed RNA sequencing (RNA seq).

RESULTS:

Most of the miRNAs were downregulated with storage time, however, miRNA 92a-3p was shown to be one of the most upregulated miRNAs after 28 days and downregulated at days 14 and 21 of storage. The level of GATA3 expression was increased on days 14 and 21 of storage and decreased on day 28 of storage. The results presented suggest that miRNA 92a-3p may control GATA3 expression in PRBCs kept in blood banks, which could, therefore, trigger an adverse immunological reaction.

CONCLUSION:

Overall, we found that there is an association between GATA3 level and miRNA 92a-3p in PRBCs which could demonstrate that GATA3 is a potential target of miR-92a-3p.
Nonsurgical Approaches for Managing Hypersplenism in Thalassemia
Authors: Almohammadi Abdullah Talal
Published: December 2024

Hypersplenism is a common manifestation of transfusion-dependent thalassemia. It results from extramedullary hematopoiesis and ineffective erythropoiesis. The end result of massive splenomegaly and chronic pancytopenia requiring transfusion debilitates the patient and implies a huge burden on the medical system. Classically, splenectomy has been the favorable approach, but the newer pharmacological approaches reversing the pathology or the minimally invasive radiological procedure can push splenectomy as the last resort and ultimately save the patients from the morbidity associated with splenectomy.
The Study of Mono- and Polysubstance Abuse Effects on Complete Blood Count Parameters in Samples of Iraqi Patients
Authors: Gatea Athmar Kadhim , Hussien Kareem Nasir , Al-Jabory Mohammed Ali
Published: December 2024

BACKGROUND:

Substance abuse represents a major health problem worldwide. In Iraq, the number of substance abusers increased, both single and polysubstance, alcohol and medications. Abuse of these substances is associated with changes in different blood parameters secondary to their direct immune, inflammatory, toxic and stressor effects on hematopoiesis, and indirect effect on liver and kidneys. These changes involve total white blood cell (WBC) count, especially lymphocyte count and their ratio to neutrophil count and platelet (PLT), in addition to their effect on red blood cell (RBC) and PLT parameters, and pancytopenia.

OBJECTIVES:

We evaluated the effect of substance abuse on the complete blood count (CBC) parameters.

PATIENTS AND METHODS:

This study was performed over 6 months on 114 participants; 57 of them were substance abusers and 57 were healthy people from Al-Sadiq Teaching Hospital/Psychiatry Department. A questionnaire was used to collect the demographic data related to substance including type, number and duration of abuse. In addition a blood sample was collected from the participants for CBC assessment.

RESULTS:

There is a significant difference between substance abusers and healthy people in WBC parameters only in lymphocyte count (P = 0.004) and neutrophil/lymphocyte ratio (P = 0.03). In RBC parameters, RBC count (P = 0.005), mean corpuscular volume (P = 0.008), mean corpuscular hemoglobin (P = 0.04), and red cell distribution width-standard deviation (P = <0.0001). In PLT parameters, PLT count (P = 0.007), mean PLT count (P = <0.0001), PLT-large cell ratio (P = <0.0001), and PLT/lymphocyte ratio (P = 0.0006). For the duration of substance abuse as well as the number of substance abuse, the only significant change in the CBC was involving the lymphocyte count (P = 0.04).

CONCLUSION:

Polysubstance misuse is widespread in samples taken and has a significant effect on different hematological parameters. This finding is correlated with different studies worldwide increasing the need for attention payment in the follow-up and management of drug addicts.
Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy
Authors: Alzahrani Musa Fares
Published: December 2024

Acute myeloid leukemia (AML) constitutes a heterogeneous group of clonal myeloid neoplasms that is associated with a large number of recurrent genetic abnormalities. Mutations in IDH2 gene can be found in nearly 10% of newly diagnosed AML patients. The impact of IDH2 mutations on prognosis in the absence of other genetic abnormalities remains to be unclear in fit patients although recently believed to be favorable in less fit patients receiving less intensive therapy. Enasidenib, which is an IDH2 inhibitor, was recently developed, but it is currently not widely available and it is only approved in the relapsed or refractory setting. Moreover, fit patients with AML who fail to respond to conventional induction chemotherapy represent a high-risk group in whom the only potential cure is allogeneic stem cell transplantation (AlloSCT), which is ideally performed after achievement of complete remission following treatment with a salvage regimen. Previous studies have shown efficacy of venetoclax combination with azacitidine (VenAza) in newly diagnosed unfit patients. It is still unknown if VenAza is an effective salvage regimen for fit IDH2-mutated AML patients who fail to respond to traditional chemotherapy. Here, we report two cases with IDH2-mutated AML, both of whom salvaged successfully with VenAza, which allowed bridging to the definitive treatment of AlloSCT.
A Comprehensive Analysis of Various Airfoils for Unmanned Aerial
Vehicles/Micro Aerial Vehicles Application
Authors: Roy Indranil , Rao Sameera
Published: December 2024

The purpose of this study is to analyze different airfoils using various tools
like X-Foil and Reynolds-averaged Navier–Stokes (RANS) computational fluid
dynamic (CFD) analysis (ANSYS Fluent) and compare both the results with wind
tunnel experimental data to choose an aerodynamically efficient airfoil, which
is suitable for an unmanned aerial vehicle/micro aerial vehicle (UAV/MAV) and
its operational domain of Reynolds number. The main objective of this analysis
is to identify and give us an understanding of the airfoil that has a higher
value of Cl max and minimum possible value of Cd. This
article discusses various low Reynolds number airfoils, i.e., for the range of
Reynolds number between 50,000 and 200,000, which is mostly used for MAVs. Also,
between the range of 100,000 and 200,000 for UAVs, which have displayed
considerable performance in the past. The article also presents an effort to
understand the phenomenon of laminar separation bubbles.
Campus Bus Station Layout Planning in Mountainous Universities Based
on User Needs
Authors: Duan Ran , Tang Rui , Wang Zhigang , Zhao Yixue , Wang Qida , Yang Jiyi , Su Jiafu
Published: December 2024

The planning of mountain campus bus routes needs to take into account user
demand, convenience, and other factors. This study adopts a comprehensive
research method that combines quantitative and qualitative viewpoints. From the
perspective of university students, this article studies the demand of campus
public transportation and proposes the layout of campus bus routes in
mountainous universities to meet the needs of users. The psychological needs
questionnaire was used to investigate college students’ expectation of bus
station service function. Taking three mountain universities as examples, the
integration and selectivity of campus road networks are evaluated by using space
syntax analysis, which provides valuable insights into the quality of bus stop
areas. This article discusses the correlation between psychological needs
assessment of college students and objective conditions of campus road network.
The study concludes with the following findings: (1) The pedestrian environment
quality at the university bus station in the mountain falls below the standard,
highlighting a considerable disparity between the current conditions and the
expectations of students and faculty. (2) Both the teaching and residential
areas of the mountainous university exhibit a heightened reliance on public
transportation and usage frequency. (3) Enhancements in public transport support
infrastructure have the potential to significantly reduce transportation costs.
(4) Considering the constraints imposed by unalterable elements of the existing
pedestrian network, the positive impact of bus stop facilities and green
landscapes can alleviate challenges associated with limited road network
options, thus facilitating pedestrian mobility. This research lays the
groundwork for further optimization of the campus layout in mountainous colleges
and universities.
Qualified Hoses for Marine Applications
Authors:   Hydraulic Hose and Hose Fittings Committee
Published: December 2024

The following list consists of hose data provided as of December 2024 and is for convenience in determining acceptability of nonmetallic flexible hose assemblies intended for usage under 46 CFR Part 56.60-25. Where the maximum allowable working pressure (MAWP) or type of fitting is not specified, use the manufacturer’s recommended MAWP or type of fitting. This list has been compiled by SAE staff from information provided by the manufacturers whose product listings appear in this document.

Manufacturers wishing to list their products in this document shall:

Successfully test their hose to the requirements of SAE J1942, Table 1.

Submit a letter of certification to the SAE J1942 test requirements for each specific type of hose tested (see sample table, Table 1) along with the test results. All sizes should be included in the same letter, which must also include all of the information necessary to make an SAE J1942-1 listing.

SAE will review the letter and may, at their discretion, request to see further test results. A copy of the submittal letter marked “Accepted for Listing” will be returned to the applicant upon approval.

The cutoff date for inclusion of a hose listing in the annual SAE Handbook is September 30 of the preceding year. However, listed hoses may be used on vessels as soon as the “Accepted for Listing” letter is issued by SAE.
Instructions for Using Plug-In Electric Vehicle (PEV) Communications, Interoperability, and Security Documents
Authors:   Hybrid - EV Committee
Published: December 2024

This SAE Technical Information Report (TIR) establishes the instructions for the documents required for the variety of potential functions for PEV communications, energy transfer options, interoperability, and security. This includes the history, current status, and future plans for migrating through these documents created in the Hybrid Communication and Interoperability Task Force, based on functional objective (e.g., [1] If I want to do V2G with an off-board inverter, what documents and items within them do I need, [2] What do we intend for V3 of SAE J2953, …).
Conceptualization and Development of a Web-based Platform for Multicultural Mathematics Resources
Authors: Abah Joshua Abah , Chinaka Taurayi Willard
Published: December 2024

This study reports on the conception and development of an online ethnomathematics instructional content repository for mathematics teachers. The study adopts a developmental research design to build a platform on WordPress, a free and open-source content management system (CMS) based on PHP & MySQL. The presentation in this paper begins with a broad background of the intent for building the website for multicultural mathematics resources. The conceptual discussion of ethnomathematics is next presented, followed by the theory of realistic mathematics education, which is a theoretical foundation of the study. Culture-based mathematics instructional design is then conceptualised. The details of the developmental research design follow this. The core deployment of the cleanroom software development model is presented and followed by the system specification of the developed web-based platform. A preliminary assessment of VillageMath’s navigation and structure indicated that the designed innovation has the potential to aid mathematics teachers in providing the necessary guided re-invention of the mathematics classroom along the culture-based continuum. The web-based platform for multicultural mathematics resources is designed to ground culture-based mathematics instruction and student learning in the values, norms, crafts, beliefs, practices, experiences, and language derived from existing indigenous knowledge systems.
Complex Dynamics of the School Governing Body in Using an Integrated Management Approach to Maintain Discipline among Learners
Authors: Khanyile Hlengiwe Goodness , Mpuangnan Kofi Nkonkonya
Published: December 2024

The introduction of the South African Schools Act 84 of 1996 (SASA) brought about a participatory decision-making approach to school governance and professional management. This approach established school governing bodies (SGBs) and significantly influenced their roles and functions. As a result of this shift, the principal is no longer the sole decision-maker in the school. The principal's role in school management and governance has shifted to focus on being the key figure most influenced by the participatory decision-making process and the primary implementer of School Governing Body (SGB) policies.  This study explored the experiences of SGBs in using an integrated management approach to undertake their role in maintaining discipline in high schools in the context of multiple deprivations. This research employed a qualitative approach, using interviews and document analysis to collect data from a targeted group of participants, including two teachers, four SGB members who are also parents, and two student leaders. The collected data were analyzed using thematic analysis, with the findings organized into relevant themes. The findings highlight key factors contributing to disciplinary challenges among learners in schools, including the absence of positive role models in the community, inadequate training for individuals managing disciplinary issues, unstable societal behaviours, dysfunctional family dynamics, and minimal parental involvement in their children's education. It was recommended that integrated management seminars be organized to educate all stakeholders on their roles in addressing learner discipline. Additionally, programs should be implemented to enhance parental involvement in schools. Furthermore, schools should collaborate with the community to address poverty effectively.
Swimming Against the Tide: Resource Mobilization and its Implications for Rural Schools of South Africa
Authors: Mkhize Themba Ralph , Ndwandwe Ntokozo Dennis
Published: December 2024

In a developing country like South Africa, the quality of education has a pivotal role in eliminating poverty and bringing about economic transformation. This constitutes the central goal of the National Development Plan. However, research has consistently demonstrated that providing quality education is linked to the availability or the absence of resources in South Africa. Therefore, in rural communities where resource scarcity is prevalent, the goal of quality inclusive education for all remains elusive and impossible to achieve. Driven by this challenge, in this study, we elicited insights from various stakeholders in a rural community about how they mobilize resources or can enhance resource mobilization in their context. We adopted a qualitative research approach, employing participatory methodologies such as transect walks, SWOT analysis and photovoice to engage the participants on what they described as resources in their rural context and how these resources could be mobilized. The findings presented three sets of capital under which resources that may drive the provision of quality education can be housed. These are human capital, cultural capital, and social-organizational capital. Based on the findings, we argue that the dominant discourse that rural communities lack capital is a “half reality” and that the challenge is the lack of awareness of what is available and how it can be harnessed to enhance the provision of quality education. We therefore recommend focused approaches to resource identification and mobilization.
CLINICAL EVALUATION OF VYOSHADI GUTIKA IN VATAJA PRATISHYAYA (ALLERGIC RHINITIS)
Authors: - Archana , Verma Keerti , k. Singh Sanjay
Published: December 2024

The present clinical trial was carried out with the prime aim of assessing the effect of Vyoshadi Gutika on Vataja Pratishyaya in children between 5 and 16 years of age. It can affect any age group, but it is more prevalent in children. Pratishyaya is one of the most common diseases among Nasa Roga. This is defined as the condition where the secretion is produced due to the vitiation of Vata and Kapha at the root of the nose which flows down through the nose against the inspired air. Vataja Pratishyaya can be correlated with Allergic Rhinitis. Allergic rhinitis is caused by the inflammation of airway mucosa with hypersensitivity and is characterised by watery nasal discharge, nasal obstruction, sneezing, nasal dryness, hoarseness of voice and headache [1]. Managing the disease is essential as it can lead to the obstruction of Prana Vayu. The ancient Acharya developed various Ayurvedic formulations through continuous study, experiments, observation and judgements. Vyoshadi Gutika is one of the formulations mentioned in the Sharangadhara Samhita Madhyam Khand 7th chapter under Kumar-Tantra and has been chosen for the present study.
Aim: To evaluate the efficacy of Vyoshadi Gutika in Vataja Pratishyaya.
Objectives: -To provide an economical and safe herbal formulation for Pratishyaya. To observe the adverse ef-fects of the drug during the clinical trial.
Methods: A total of 40 patients were registered between 5 and 16 years of age with classical symptoms of Prat-ishyaya. The drug Vyoshadi Gutika was administered in a daily dose fixed as per Young’s rule. The trial lasted 35 days.
Result: Overall, the study revealed that Vyoshadi Gutika has a highly significant effect on the management of Vataja Pratishyaya.
A REVIEW OF KARNADHOOPANA FROM BRIHATRYAYI: AS A TREATMENT OF
VARIOUS KARNAGATA VYADHIS
Authors: Pradnya Kharat , Manisha Pingale
Published: December 2024

In Ayurveda's holistic approach to health and wellness, Dhoopana karma Is a remarkable gem. Karna Dhoopana,
used in Shalakya tantra, stands out as a traditional therapy specifically designed for treating ear diseases. Karna
Dhoopana is performed by introducing medicated smoke into the ear canal. This article aims to study Karna
Dhoopana from various references available in brihatryayi and contemporary ayurveda literature across the internet. Materials and methods used to achieve the objectives are relevant and available in Ayurveda Samhita and
articles from the internet. The following article discusses the introduction of Karna Dhoopana, the probable mode
of action of the treatment, and Karna Dhoopana yogya Dravya / yoga indicated according to various diseases and
suggested SOP.
AYURVEDIC ASPECT OF PELVIC ORGAN PROLAPSE-A REVIEW
Authors: Raju Ade Dhanashree , Khalache Tinku Ganesh
Published: December 2024

The uterus, urinary bladder and rectum are the pelvic organs. These organs are held in their appropriate anatomi-cal position by the support of pelvic floor muscles and ligaments. But when laxity or loss of tone is seen in these muscles and ligaments, these pelvic organs get displaced in a downward direction due to their weight and gravi-ty. After some time, it results in the prolapse of the respective organ. Pelvic organ Prolapse (POP) is found commonly in old age, i.e. in the menopausal age group. Mostly, it is seen in multipara women, i.e., a woman who gives birth to more than one child. Mostly it is associated with the feeling of something coming out of the vagina, which causes discomfort while sitting or walking. Also, it leads to some urinary symptoms such as ur-gency or frequency or painful micturition, etc. This includes first-degree, second-degree, and third-degree uterine prolapse and cystocele. ureterocele, rectocoele. Management can be done using surgical and non-surgical meth-ods. In Ayurveda, it can be corelated to yonirogas Mahayoni, prasramsini, phalini/andini and vatiki yonivyapat. If any women who are prone to mithya ahara viharas, dukha prasava dushta arthava, who didn't follow proper dinacharya, rajaswalacharya, garbhini paricharya, sootika paricharya, results in improper dosha vitiation, rasa, rakta, mamsa, medo dhatu dushti, which in turn causes upadhatu arthava, kandara, sira vitiation resulting in loosening of ligaments, muscles and structures associated with pelvic organ supports, causing organ to prolapse. Prasramsini can be corelated to first or second-degree uterine prolapse, Andini/phalini as cystocoele, and Mahayoni as third-degree uterine prolapse/procidentia. The lakshana "Bhramsa in Vatiki yonivyapat” can be corelated to the displacement of garbhashaya.
AN AYURVEDIC APPROACH OF PCOS: A REVIEW ARTICLE
Authors: Mukayanamath Pooja , Ram Sunita D.
Published: December 2024

Polycystic ovarian syndrome is multifactorial endocrine disorder affecting one in every five women between 15-
30 years of age in India. As PCOS may lead to infertility-like conditions, it becomes essential to contrive remedies for these conditions. Ayurveda, being a traditional science, can help treat such conditions. Using different
Ayurvedic principles, we can diagnose & treat such conditions as PCOS.
GENETICS AND HEREDITY THROUGH AYURVEDA SAMHITAS
Authors: S Sruthi , Murthy Mamata , Hegde Shruti
Published: December 2024

Understanding Genetics and Heredity through the kaleidoscope of Ayurveda enables Vaidyas to realise the mer-its of preventive measures required in planning a swasthakutumba and thereby building a swasthasamaja. Sci-ence of Genetics and Heredity is creating revolutionary waves across the globe with the development of tech-nology and evidence-based medicine. Adequately training our practitioners to deal with the diagnosis & man-agement of these disorders is the need of the hour. For preventive measures, the right diagnosis is mandatory, and for the latter, dosha-dushya sammurchana should be assessed. Acharyas have mentioned dushti of beeja, beejabhaga or beejabhaga-avayava, invariably having repercussions on offspring. Shareera Sthana, dedicated exclusively to garbha sambhava and vikasa, is thus a foundation in this sector. A faithful and comprehensive approach to the rachanatmaka shareera from the beginning is mandatory. Therefore, a retrospective study of Rachana Shareera for a deeper insight into Genetics in Ayurveda is attempted.
MATERIALS AND METHODS
Relevant Samhitas were screened for critical literary review of the references regarding garbha paricharya, several articles from indexed journals, PubMed, and other textbooks were also used to acquire information re-garding genetics, heredity, and related disorders.
CONCEPTUAL UNDERSTANDING OF SENILE DEMENTIA - AN AYURVEDIC PERSPECTIVE.
Authors: Vinay Vardhan Vedantam , Kamath.T Shrilatha , G bhat Vijayendra
Published: December 2024

Senile Dementia is a prevalent condition among the ageing population, characterized by a significant decline in
cognitive functions that interfere with daily activities. Key cognitive areas affected include memory, visuospatial
skills, language, and problem-solving abilities. It affects 5% of individuals over 65 and 33-50% of those over 85
years. There are 7.7 million new cases of dementia every year. Approximately 6% of the population above 60
years are suspected of dementia. Senile dementia can be understood as an alteration of Smriti(memory). In Jara
(old), where a person faces difficulties in Grahana(Receiving), Dharana(Retention), Smarana(Remembrance),
Vachana(Speech) and Vijnanashakti (Intelligence) is considered Smriti Bhramsha (Dimished memory). Jara
Chikitsa is a branch that focuses on health management for ageing and addresses disorders related to old age. It
is known as Vardhakya Janya Vikaras. Vata is the dominant Dosha, which gets vitiated along with Rajas and Tamas, leading to Smriti Bhramsha .
AGANTUJA VRANA IN PRAMEHI (INSULIN DEPENDENT PATIENT) – A CASE STUDY
Authors: Mohanty Bishnupriya , Joshi Alhad
Published: December 2024

Increase cases of Madhumeha now become evident cause for Prameha Pidaka; when we fail to approach the disease in precise way. Sometime pathology of original disease remains associated or may not. Those Pidakas are
addressed here as Agantuja Vrana. Apamarga Kshara, Aragwadhadi Kashayam tablet, Shilajitwadi Loha and
combination of other Bhashmas are used here with bi-dimensional approach of tropical as well as internal application. The clinical success has discussed in this paper.
EFFECTS OF AMLAKI CHURNA ON BLOOD GLUCOSE LEVELS IN PRE-DIABETES & TYPE 2 DIABETES MELLITUS: A CASE STUDY
Authors: Mohanty Bishnupriya , Yadav Rohit Kumar
Published: December 2024

Diabetes being the “iceberg disease”, the incidence of type 2 diabetes mellitus has increased globally due to sedentary lifestyle, food habits, stress, strain, etc. The prevalence of type 2 diabetes mellitus is over 26.4% of the
population in Goa. In Ayurveda Acharya Bhavaprakasha quotedआमलकी(Emblica officinalis) as
“रक्तपित्तप्रमेहपिरंवृष्यंरसायनम” and explains pharmacological action of आमलकीin haritakyadi varga (shloka no.
37-41) as वयस्थािन, रसायन, पिदोषशामक and specifically Pramehaghna. It is considered the best Naimittika Rasayana for the management of diabetes mellitus. Henceआमलकी churna is selected in type 2 diabetes mellitus for
the study. In the present study 5 subjects of pre-diabetes and 5 subjects of known case of diabetes mellitus are
selected. All 10 subjects were treated with आमलकी churna 2 gm twice daily half an hour before food with warm
water. The effect of therapy was evaluated at the interval of 4 weeks which was done on the basis of objective
parameters. The objective parameters were fasting blood sugar levels, post prandial blood sugars and glycosolated
hemoglobin (HbA1C).It was seen that आमलकी churna has reduced blood sugar levels. It also reduced the dose of
conventional drug which may cause side effects with long term use.
A CONCEPTUAL STUDY ON YOGIC BREATHING AND ITS COMPARISON WITH THE RESPIRATORY MECHANISM ACCORDING TO MODERN SCIENCE
Authors: Bochalya Anita , Gumber Tamanna , Gupta Suwalal , Bhatnagar Vikash , M. Lahange Sandeep
Published: December 2024

Breathing influences every cell in the body and is closely connected to brain function. On average, a person takes
15–16 breaths per minute, totaling around 21,600 breaths daily. By controlling Prana, the life force, one can effectively regulate bodily functions and enhance the development of the body, mind, and spirit. Breaking governs the
mind, intellect, and ego, helping to balance one's individual and cosmic existence. Hatha Yog views Prana Tattwa
(the life force principle) as more important than Manas Tattwa (the mental principle), as Prana remains active even
when the mind is at rest, such as during sleep. Therefore, Prana is considered more essential than the mind.1
Before practicing Pranayama (breath control), Yoga practitioners must train the muscles of the pulmonary cavity
and become more aware of their breathing patterns. This helps strengthen their vital energy and prepares them for
practice. It is crucial to breathe slowly, deeply, and rhythmically while maintaining a calm and peaceful state of
mind, as irregular breathing can disrupt brain function.
ANUSHLAYA KARMA IN THE MANAGEMENT OF FATTY LIVER DISEASE – A
CASE REPORT
Authors: R Megha , Thyagaraja C
Published: December 2024

Background: Fatty liver is one of lifestyle diseases, though it is reversible. Fatty liver, which can be correlated to
Yakrit-vikara of ancient science, Acharya Sushruta has mentioned Siravyadhana at Dakshina Kurpara Sandhi.
Materials and methods: A case study on 51 years old male with complaints of distension of abdomen, decreased
appetite, burning sensation in the epigastric region, fatigue since one year. Diagnosed with Grade 2 fatty liver was
treated with four sittings of Siravyadha at Dakshina Kurpara Sandhi, which was done at intervals of 7 days, and
follow-up was taken after 15 days on completion of the treatment. Result & conclusion: U.S.G. Abdomen was
repeated after 15 days and showed encouraging results and improved liver grade; symptomatic improvement was
also seen. This case report helps to know the efficacy of Siravyadhana as Ardachikitsa in Shalya Tantra and reaffirms the classical reference on specific sites of Raktamokshana in Yakrit-Viikara and other specific clinical condition.
EFFECTIVE MANAGEMENT OF LOBULAR CAPILLARY HEMANGIOMA THROUGH KSHARA KARMA – A CASE REPORT
Authors: K Honnaik Anupama , Chandanshive Anil B. , Kumbar Ashwini
Published: December 2024

Lobular capillary hemangioma is a benign vascular tumour that arises in tissues such as the skin and mucous
membranes. The ratio of males to females was 1: 1.2, resulting from an imbalance in angiogenic factors, which
leads to a rapid proliferation of capillaries of a neovascular, friable, and lobulated character. Skin presentation is
rare and most observed with a history of trauma. Reactive granulation will result in erosion, ulceration, and bleeding. Ulceration, bleeding, and cosmetic appearance demand its treatment, which is only the excision. Different
therapies have variable degrees of success and variable rates of recurrence. This clinical condition is well explained in Ayurveda under Arbuda and Dustavrana. In the present case, a 14-year-old female patient diagnosed
with an ulcerated lobular capillary hemangioma was successfully treated with complete excision and Kshara karma with Tikshna Apamarga pratisaraniya Kshara followed by vrana chikitsa. A follow-up study has revealed no
recurrence after two years.
ANALYSIS OF DINACHARYA OR THE DAILY REGIMENS FOR THE MAINTE-NANCE OF HEALTH
Authors: S Anuradha. , T M Chaitra , T V Varun
Published: December 2024

The aim of Ayurveda is to maintain the health of a healthy individual and treat the diseased one. Our acharyas describe that man who has Doshas, Dhatus, Agni, mala and Kriyas as usual and whose Atma, Indriya, and Manas are peaceful is said to be healthy. The word Dinacharya has two words: Dina, which means day/day to day, and Charya, which means regimens and duties to be carried out. Dinacharya aims to maintain normal health and increase the life span without any disease. Dinacharya, or the daily routine in Ayurveda, emphasises the significance of aligning daily activities with natural rhythms to promote holistic well-being. This article ex-plores the principles of Dinacharya, detailing its components such as waking, personal hygiene, meals, work, and rest. By integrating these practices, individuals can enhance physical health, mental clarity, and emotional balance. The article highlights the scientific underpinnings of Dinacharya, illustrating its relevance in modern lifestyles marked by stress and imbalance. Furthermore, it discusses practical applications for implementing Dinacharya in everyday life, demonstrating how these ancient wisdoms can foster resilience and vitality in con-temporary society. Through this exploration, the article aims to inspire readers to adopt a structured daily routine that harmonizes with their biological clock, ultimately promoting a healthier, more fulfilling life.
Here, an attempt was made to understand the importance of Dinacharya in all the points mentioned above.
A CASE STUDY ON MANAGEMENT OF KATIGRAHA WITH MATRA BASTI AND
BANDANA
Authors: Sajith M , Prakash Dave Om , Pai Surekha , Komalankutty Anagha
Published: December 2024

Katigraha is a condition classified under Vataja nanatmaja vyadhi, primarily characterised by varying degrees of pain in the lower back region, ranging from mild to severe. Low back pain can stem from various acute or chron-ic conditions that significantly impact an individual's daily activities. This case study discusses a female patient who presented with acute pain in the lumbosacral area. Her pain was evaluated using the Visual Analog Scale (VAS) and the Oswestry Low Back Pain Disability Scale. The patient underwent treatment involving bandaging with Murivenna, Matravasti with Dhanwantara Tailam, and was administered Shamanaoushadhi’s such as Rasnasaptaka kwatha, Trayodashanga guggulu, and Shallaki 400 tablets for ten days. The patient's pain, disabil-ity, and tenderness were assessed every second day. By the tenth day, she reported improved flexibility and comfort while lying supine. The patient experienced significant relief from pain and stiffness and enhanced walking ability.
PURGATION THERAPY IN BRONCHIAL ASTHMA (“TAMAKE TUVIRECHANAM”)-A CASE REPORT
Authors: singh Ramraj , Dorage Priyanka , Gulhane Jayant
Published: December 2024

With the highest frequency in developed nations, asthma is a widespread illness that is becoming more and more
common worldwide. Approximately 300 million individuals globally have asthma, and by 2025, an additional 100
million are expected to be impacted by the condition. Ayurveda has been an outstanding source of Internal detoxification therapy and herbal medicine since prehistoric times. Patients seeking alternative and complementary medicine to treat their asthma are doing so since current asthma therapy is not working well enough owing to side effects. A 52-year-old male patient with a known case of recurrent bronchial asthma who is undergoing scheduled
purgation therapy for the condition ("TAMAKE TU VIRECHANAM") has shown significant improvement with
long-lasting benefits and fewer adverse effects.
A CONCEPTUAL REVIEW ON MOOTRASHMARI W.S.R TO UROLITHIASIS
Authors: Holeyannavar Madhu M , - Aniruddha
Published: December 2024

Urolithiasis is a global health problem with a high recurrence rate. It is also called Nephrolithiasis or kidney
stones. Urolithiasis is the formation of calculi, or a condition associated with urinary calculi. The term calculi are
synonymous with uroliths, stones, or crystals. Kidney stone formation or Urolithiasis is a complex process
resulting from several physiochemical events, including supersaturation, nucleation, growth, aggregation, and
kidney retention. The most common stones are struvite, calcium oxalate, urate, cystine and silica. Mootrashmari
is a disease manifesting essentially from suppressing the urge to void. According to pathology, the
Sthansamshraya stage of the disease Mootrashmari takes place in Basti, considered the Mootravaha strotas.
Thus, due to similar pathophysiology and clinical features, Mootrashmari can be linked to Urolithiasis. This
article attempts to compile and interpret scattered references of Mootrashmari in Ayurvedic texts with the concept
of urolithiasis.
ARCHITECTURAL DESIGNS MENTIONED IN CHARAKA SAMHITA FOR DIF-FERENT TREATMENT PROTOCOL -A REVIEW
Authors: B.Kompalwar Nagkrishna , M Gahunge Pankaj , N Katariya Nisha
Published: December 2024

Charak Samhita mentions various architectural designs or structures in various chapters for treatment purposes or
for Vihar (accommodation) in different types of diseases or conditions. This article compiles and reviews all such
structures mentioned in different places throughout the Charak Samhita. like Sutikagara, Kumaragara mentioned
in Sharirsthana, Aturalaya, Kutisweda mentioned in Sutrasthana, Dhara graha, Kutipraveshika mentioned in
Chikitsa sthan, etc. Each structure will be described in the format purpose, its designs and structure, its importance in the present era, and Vastu Shastra’s view. We have taken some of Vastu Shastra's references wherever needed to explain structure or architectural design.