bluuebunny/crossref_metadata_2025 huggingface dataset:
The Clinical Value of Long Noncoding RNA DDX11-AS1 as a Biomarker for the Diagnosis and Prognosis of Hepatocellular Carcinoma
Authors: Luo Xiaojun , Wang Yang , Zhang Xi , Liu Wenbin
Published: August 2022

Hepatocellular carcinoma (HCC) is a high-mortality malignant tumor with genetic and phenotypic heterogeneity, making predicting clinical outcomes challenging. The purpose of this investigation was to examine the potential usefulness of lncRNA DDX11 antisense RNA 1 (DDX11-AS1) as a biomarker for diagnosis and prognosis in hepatocellular carcinoma (HCC). The TCGA-LIHC datasets were searched for patients’ clinical information and RNA-seq data, which were then collected. Relative expression levels of DDX11-AS1 in HCC tissues were determined by qRT-PCR. In order to test the sensitivity and specificity of the DDX11-AS1 receiver, receiver operating characteristic curves were utilized. The association of DDX11-AS1 expression with clinicopathological factors or prognosis was statistically analyzed. We found that the levels of DDX11-AS1 were higher in HCC specimens than in normal specimens. ROC analysis showed that DDX11-AS1 was a useful marker for discriminating HCC tissues from normal nontumor specimens. According to the results of clinical tests, a high level of DDX11-AS1 expressions was significantly related to the pathologic stage (

p
=
0.015

) and the histologic grade (

p
<
0.001

). Survival studies indicated that patients with higher DDX11-AS1 expression had a significantly poorer overall survival (

p
=
0.005

) and progression-free interval (

p
=
0.003

) than those with lower DDX11-AS1 expression. Multivariate survival analysis verified that DDX11-AS1 expression level was an independent predictor for HCC patients. Overall, DDX11-AS1 may serve as a tumor promotor during HCC progression, and its high level may be a potential marker for HCC patients.
Noncontact Defect Detection Method of Automobile Cylinder Block Based on SVM Algorithm
Authors: Yan Juncen
Published: August 2022

Based on the problems encountered in the gateway system, this article developed the SVM algorithm support vector machine auxiliary system based on the function of the hybrid network gateway to help the gateway dynamically adjust its operating status to ensure the stability of the gateway system and the real-time internal data. This paper studies the noncontact defect detection system of automobile cylinder block on the basis of the SVM algorithm. There are many thin holes in the wall of automobile engine cylinder block, the structure is complex, and the processing is easy to deform. In order to solve the problem of deformation of the automobile engine cylinder block during the milling process, this paper uses a combination of simulation and experiment to analyze the clamping deformation and milling deformation during the machining of the top surface of the automobile cylinder block and proposes the control of the milling deformation profile error measure. Aiming at the problems of backward detection technology, low detection efficiency, and low detection accuracy for the detection of defects on the inner surface of the master cylinder of automobile brakes, this paper uses the machine vision technology to choose the noncontact method of measurement. The use of laser nonultrasonic contact systems is not limited to workpieces having regular shapes, such as planes and cylinders. It is limited to workpieces with regular shapes such as planes and cylinders. In the automotive and other industrial fields, for various curved parts with free-form surfaces, nondestructive testing techniques of laser nonultrasonic contact systems are generally required to find defects. In the research of the noncontact defect detection method of the automobile cylinder block based on the SVM algorithm, this paper hopes that the detection efficiency and detection accuracy of the inner surface of the brake cylinder can be improved, and the defect location can be accurately found.
Large-Scale Agile Transformations for Software Quality Assurance: An Empirical Case Study from Pakistan
Authors: Wadood Kamran , Nigar Natasha , Shahzad Muhammad Kashif , Islam Shahid , Jaleel Abdul , Abalo Douhadji
Published: August 2022

Software quality plays an important role in the easy and quick adoption of a software product by the end users. Agile methods have proven to play an effective role in ensuring software quality; however, the public sector is hesitant in its adoption. This study evaluates the adoption of agile methods in the public sector in-house software development and capitalization of potential benefits. A quantitative approach is used with 28 survey questionnaires based on budget, time, quick debugging and correction, maintenance, easy testing, and installation as software quality components to assess the employability of agile methods. The questionnaire was served to 216 information technology (IT) professionals (project managers: 6%, developers: 61%, quality assurance (QA) leads: 8%, and testers: 25%) from the public sector companies having experience in software development using agile and waterfall methods. The quality components and hypotheses are evaluated using the T-test and chi-square test, respectively, with a 95% confidence interval. The results highlight the benefits of using agile methodologies for software quality components in the public sector. Additionally, the findings demonstrate how agile software development approaches significantly affect the quality of software products and successful delivery within budget and deadline.
Effect of Seed Pretreatment Methods on Germination and Early Seedling Growth of Senna spectabilis
Authors: Zembele Erick R , Ngulube Elisha S
Published: August 2022

The objectives of the study were to evaluate the effect of pretreatment methods on germination of Senna spectabilis seed and determine the effect of pretreatment methods on height and root collar diameter growth of Senna spectabilis seedlings. The experimental treatments involved were control; seeds soaked in cold water for 12 h, 24 h, and 48 h; seeds soaked in hot water and allowed to cool for 12 h, 24 h, and 48 h; and nicked seeds using secateurs. The experiment was arranged in a completely randomized design (CRD) with four replications. The data variables assessed were seedling height, root collar diameter, and survival rate. Data were subjected to one-way ANOVA using Minitab software. Results showed that there were significant differences

p
≤
0.
05

among treatment means on germination, seedling height, and root collar diameter, while the survival rate was not statistically significant

p
≥
0.05

. Nicked seeds and those soaked in hot water and allowed to cool for 12 h had an outstanding performance in terms of germination and seedling growth. It is, therefore, recommended that farmers should be encouraged to use nicked and hot water soaked for 12 h seed in order to achieve high germination and growth efficiencies in their homestead gardens.
Educational Evaluation of Piano Performance by the Deep Learning Neural Network Model
Authors: Liao Yuanyuan
Published: August 2022

In recent years, the piano education industry has occupied a huge market. However, the automatic evaluation function of piano performance has shortcomings in existing piano education products. Deep learning (DL) algorithm and the recurrent neural network (RNN) structure can help in automatics evaluation function of the piano performance. This paper proposes a Musical Instrument Digital Interface (MIDI) piano evaluation scheme based on the RNN structure and the Spark computing engine using the Deeplearning4J DL framework. The Deeplearning4J framework can run on the Java Virtual Machine; therefore, the entire system does not require cross-platform development. The Spark distributed computing engine realizes parallelization in music data preprocessing, feature extraction, and model training. Combined with the training user interface (UI) provided by the Deeplearning4J, it can improve developmental efficiency. Additionally, the RNN parameters are analyzed. The results demonstrate that the error value of the three-layer RNN structure is smaller than other closest rivals’ techniques. In particular, few piano training institutions and MIDI website datasets are used as the basis, and the experimental samples are collected. The neural network is trained, and the performance of the evaluation model is tested. The results show that the evaluation outcomes of the designed performance evaluation model for the piano are fundamentally consistent with the real levels of the players with assured feasibility; after 3k times of the training periods, the error of the RNN model is close to 0.01 and the network converges.
Dynamic Audit of Internet Finance Based on Machine Learning Algorithm
Authors: Zhang Jianhui
Published: August 2022

Internet finance is a direction for the development of the new system. The existing research mostly analyzes how to build a risk early warning system from a qualitative perspective to promote a more healthy development of Internet finance companies. This paper aims to study the role of machine learning algorithm in the dynamic audit of Internet finance. It proposes Apriori algorithm, data mining, Bayesian network, and other methods, and related experiments are also conducted on the dynamic audit of Internet financial risk based on machine learning algorithm. The experimental results show that in Internet finance, private enterprises have the highest profit rate, which can reach 20%. But the higher the profit, the greater the financial risk. The machine learning algorithm can make a good intelligent identification of the capital circulation of Internet financial enterprises. This can provide timely feedback on abnormal capital problems, which can help auditors better manage the company’s capital circulation.
Adaptive Feature Analysis in Target Detection and Image Forensics Based on the Dual-Flow Layer CNN Model
Authors: Liang Nannan , Xu Haifeng , Zhang WanLi , Cui Lin
Published: August 2022

With the rapid development of artificial intelligence technology, image editing technology has evolved from relying on software such as Photoshop and GIMP for manual modification to using artificial intelligence technology to achieve intelligent and automated tampering of images. Editing, falsifying, and disseminating digital images have become simple and easy, leading to a crisis of confidence in digital images and reducing their reliability as judicial evidence. Therefore, how to identify falsified images, improve their trustworthiness, and avoid judicial injustice has become a problem that must be overcome in the information age. In this paper, we propose a target detection and adaptive feature analysis in image forensics based on a dual-flow layer CNN model, which can effectively perform image forensics. The results show that our algorithm has a clear theoretical basis, a small operational complexity, and a high detection accuracy.
Prediction Method of User Behavior Label Based on the BP Neural Network
Authors: Shen Ruihang
Published: August 2022

With the development of big data, precision marketing helps businesses to be more efficient in selling products and stand out from the fierce competition. In this paper, the backpropagation neural network is introduced as an approach to analyze the data of user online behaviors and create labels for each user. In this way, the business will be able to realize accurate user classification and forecast users’ future behaviors and thus achieve precision marketing. The study tested the backpropagation neural network with a real user behavior dataset from Taobao for a recommendation. According to users’ behavior data, the network successfully classified users into 5 clusters with distinct labels and this information can give the business valuable insights into their customers for precision marketing and selling products.
RPNs Levels Are Prognostic and Diagnostic Markers for Hepatocellular Carcinoma
Authors: Zheng Wangyang , Zheng Yuling , Bai Xue , Zhou Yongxu , Yu Liang , Ji Daolin , Leng Kaiming , Meng Nanfeng , Wang Hang , Huang ZiYue , Xu Yi , Cui Yunfu
Published: August 2022

The ribophorin family (RPN) is an essential regulatory subunit of the proteasome. By influencing the ubiquitin-proteasome system activity, ribophorins (RPNs) are responsible for almost all physiology and pathology processes of mammalian cells. Nevertheless, little is known about the role of RPNs in HCC. In this work, we first evaluated the transcriptional levels and the prognostic and diagnostic value of RPNs based on the public database. Firstly, we found all RPNs were surprisingly consistently upregulated in HCC tissues. Moreover, the RPNs’ expression pattern is correlated with HCC tumor grade. The TCGA HCC platforms’ data indicated that RPN2, RPN3, RPN6, RPN9, RPN10, RPN11, and RPN12 have robust diagnosis values. Then, survival analysis revealed that the high expression of RPN1, RPN2, RPN4, RPN5, RPN6, RPN9, and RPN11 was correlated with unfavourable HCC overall survival. Then, genetic alteration, immune infiltration feature, gene-genes network, and functional enrichment for RPNs indicated that RPNs have many potential biosynthesis activities expert for UPS functions. Moreover, western blot and qRT-PCR results confirmed these results. The silencing of RPN6 and RPN9 significantly reduced HCC cells’ proliferation, migration, and invasion ability in vitro. An in vivo tumor model further validated the oncogene effect of RPN6 on HCC cell growth. Moreover, RPN6 and RPN9 could promote cell migratory and invasive potential by affecting the epithelial-mesenchymal transition (EMT) process. In summary, this study suggests that the RPN family has the potential to be potential biomarkers and targets for HCC.
Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection
Authors: Zhang Jie , Chen Yanlei , Liu Zhiwu , Pan Zhihao
Published: August 2022

Endoscopic submucosal dissection (ESD) is a minimally invasive technique to completely peel the pathological mucosa from the submucosa under endoscopy, which has been often utilized to treat early gastric cancer. During the operation, anesthesia is required to reduce the discomfort due to the complexity, high risk, and longtime operation of ESD. In this study, we compared different anesthesia methods on anesthetic effect and postoperative pain in patients (≥65 years old) with early gastric cancer during ESD. For this purpose, 60 patients with early gastric cancer who were more than 65 years old were selected from January 2019 to December 2021, where 30 patients treated with simple intravenous general anesthesia were divided into the simple group and 30 patients treated with intravenous combined inhalation general anesthesia were regarded as the composite group. The hemodynamic index, wake-up time, postoperative pain intensity, operation time, and the incidence of adverse reactions were compared between the two groups. For the hemodynamic index before incision, after incision, and at the end of the operation, the mean arterial pressure (MAP) in the composite group was higher than that in the simple group

P
<
0.05

and the heart rate (HR) was lower than that in the simple group

P
<
0.05

. After the ESD operation, the wake-up time and visual analogue scale (VAS) in the composite group were lower than those in the simple group

P
<
0.05

. In addition, the ESD operation time and incidence of adverse reactions in the composite group was significantly lower than that in the simple group

P
<
0.05

. These results showed that intravenous combined inhalation general anesthesia had a good anesthetic effect, stable hemodynamics during ESD operation, and slight postoperative pain.
Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism
Authors: Tang Jie , Zhu Jichao , Shu Longwen , Huang Xiaohong , Ma Siming
Published: August 2022

Objective. The study aimed to investigate the relationship between human leukocyte antigen (HLA-DQB1) gene variants and recurrent miscarriage. Methods. HLA-DQ gene polymorphisms (PCR-SSP) were detected in 50 couples with recurrent miscarriage (URSA group) and 30 couples with normal births (control group) using sequence-specific primer-guided polymerase chain reaction. Results. The frequency of the DQB1

∗

0303 allele in the URSA group (21.50%) was substantially higher than that of the control group (11.67%) (

P
=
0.0260

0.05, RR = 1.754); however, the frequency of the DQB1

∗

0302 allele in the URSA group (4.00%) was substantially lower than that of the control pair (10.00%) (

P
=
0.0318

0.05, RR = 0.400); the frequency of sharing one allele was 46.00% (23/50) in the URSA group and 0.00% (0/30) in the normal control group; the frequency of sharing two alleles was 40.00% (2/50) in the URSA group and 43.33% (13/30) in the normal control group, with no significant difference between the two groups. Conclusion. For the Zhejiang population, HLA-DQB1

∗

0303 may be a susceptibility gene for recurrent miscarriage, while HLA-DQB1

∗

0302 may be protective against recurrent miscarriage, especially for women.
Etiology of Emergency Visit and In-Hospital Outcomes of Patients with COPD
Authors: Zhang Xueyang , Zhou Qingtao , Wang Shengfeng , Ma Qingbian , Sun Yongchang
Published: August 2022

Backgrounds. Patients with COPD often visit the emergency department (ED) due to exacerbation of respiratory symptoms (dyspnea, cough, and sputum production). Because manifestations of acute exacerbation of COPD (AECOPD) are nonspecific, differential diagnosis is critical in this acute setting. The causes for emergency visiting and the in-hospital outcomes are varied in patients with COPD. This study aimed to investigate the distributions of etiologies and the in-hospital outcomes of patients with COPD who presented to the ED because of exacerbation of respiratory symptoms. Methods. This was a retrospective study on COPD patients who had visited the ED and been hospitalized in a tertiary hospital because of worsening respiratory symptoms including cough, sputum production, and dyspnea from January 2017 to April 2020. Demographics, clinical manifestations, and laboratory studies in the ED were collected as the baseline data. The primary diagnosis at discharge or death was recorded. The hospitalization settings (general wards and ICU), the in-hospital outcomes, and associated factors were analyzed. Results. During the study period, 392 patients with COPD (male 302 (77.0%)), with a median age of 78 years, visited the ED and hospitalized in this hospital. The first 3 causes for emergency visit were AECOPD (n = 314, 80.1%), acute coronary artery syndrome with or without congestive heart failure (n = 24, 6.1%), and pulmonary embolism (n = 13, 3.3%). For patients with AECOPD (n = 314), 51.6% (n = 162) was admitted to ICU, and 6.4% (n = 20) died. Multivariate logistic analysis showed that age, atrial fibrillation, NT-pro BNP ≥300 pg/ml, and blood pH <7.3 were independent risk factors for ICU admission. Age, comorbid malignancy, NT-pro BNP ≥1800 pg/ml, and pneumonia on CT scan were independent risk factors for hospital mortality in patients with AECOPD. Conclusion. In COPD patients visiting the ED because of worsening respiratory symptoms, nearly 20% were due to non-AECOPD causes. For those with AECOPD, age, atrial fibrillation, NT-pro BNP ≥300 pg/ml, and blood pH <7.3 were independent risk factors for ICU admission, while advanced age, underlying malignancy, elevated NT-pro BNP, and pneumonia on CT scan were risk factors for hospital mortality.
Mutual Trust Influence on the Correlation between the Quality of Corporate Internal Control and the Accounting Information Quality Using Deep Learning Assessment
Authors: Zhao Ying
Published: August 2022

There is a close correlation between internal control and accounting information quality in the process of enterprise management, and this correlation drives the effect of internal control on accounting information quality, thus forming the effect that internal control optimization promotes accounting information quality optimization. This paper firstly gives a brief description of internal control and accounting information quality and then evaluates the correlation between internal control and accounting information quality based on deep learning and proposes a specific modeling method. Through the correlation and promotion of internal control and enterprise accounting information quality, the optimization of enterprise accounting information quality is achieved. And in combination with the actual case analysis, it is found that the method of this paper can achieve 92% accuracy of correlation analysis, and the analysis is more efficient.
Design and Optimization of Psychological Emergency Response System for College Students Based on IoT and Computational Intelligence
Authors: Wang Xiaoli
Published: August 2022

Today, when university students are the future subjects of society, psychological crises are constantly emerging. At the same time, considering the rapid socioeconomic development, competition among the best talents, cultural diversity, and the growth of temptations and events in public health, all of these put growing students through the wringer. However, when traditional sentiment data are analyzed through manual selection, it usually has some drawbacks such as small sample size, poor real-time status, high transaction costs, and high human errors. We need to use modern technology, applied technology, and computer intelligence to collect psychological data from all respondents, which is ultimately measured by sentiment data. Use the results of emotional data analysis to deal with emergencies in a timely manner. The system designed in this paper has unprecedented advantages in terms of automation, timeliness, and accuracy compared to previous participatory psychotherapy methods.
Application of Machine Learning Algorithm in Stadium Engineering Building Information Model Management System
Authors: Chen Qi , Sheng Nan
Published: August 2022

BIM (building information modeling) is a building information modeling technology. It is a modeling technology that has quietly emerged in the architectural design and construction industry and will gradually replace the traditional CAD drawing technology. In addition to carrying geometric information of graphics, it can also carry buildings and building components. The engineering and nonengineering information of the building space has a higher degree of visualization and a stronger sense of three-dimensionality, and all the building information can be put into a model. The model can provide dynamic information on engineering construction cost management processes and can be processed by a computer in real time. The purpose of this paper is to study the new method of stadium project building information model management after the introduction of deep learning technology. This article first introduces the artificial neural network under machine learning algorithms by building a neural network model and combining it with the engineering construction information model and then integrating machine learning algorithms into the construction information model technology so that the originally three-dimensional model can further information integration. Compared with the original building information model, the data processing is more efficient and the management level has greatly improved. The experimental results of this paper show that machine learning algorithms can optimize the construction information model of stadium engineering and increase the efficiency of project management by 20%.
Thermal Performance of a Dimpled Tube Parabolic Trough Solar Collector (PTSC) with SiO2 Nanofluid
Authors: Arun M. , Barik Debabrata , Sridhar K. P. , Dennison Milon Selvam
Published: August 2022

In this research work, dimple texture tubes and silicon dioxide (SiO2) nanofluid were used to analyze the performance parameters of a solar water heater. For this purpose, SiO2 was mixed with deionized (DI) water using an ultrasonic dispersion device to prepare the nanofluids (SiO2/DI-H2O). The size of the nanoparticle was in the range of 10-15 nm. Different volume concentrations of the nanoparticles in the range of 0.1% to 0.5%, in steps of 0.1%, were chosen to prepare the nanofluids to carry out the experiments. Apart from this, computational fluid dynamics (CFD) tool was used to numerically analyze the parameters affecting the performance of the solar water heater, as well as the fluid flow pattern in the dimple texture tube. During the experiment, the mass flow rate of the base fluid (water) varied in the range of 0.5 kg/min to 3.0 kg/min in steps of 0.5 kg/min. The added advantage of the dimple texture tube design led to an increase in turbulence in the flow pattern, resulting 34.2% increase in the convective heat transfer efficiency compared with the plain tube. Among all experimental modules, SiO2/DI-H2O with a mass flow rate of 2.5 kg/min and 0.3% volume concentration gives overall optimized results in absolute energy absorption, gradient temperature, and efficiency of the solar water heater. The efficiency metrics of the experimental results were compared with the simulation results, and it was in the acceptable range with an overall deviation of ±7.42%.
Identification of a Signature for Predicting Prognosis and Immunotherapy Response in Patients with Glioma
Authors: Zong Wei-Feng , Liu Cui , Zhang Yi , Zhang Suo-Jun , Qu Wen-Sheng , Luo Xiang
Published: August 2022

Glioma is a deadly tumor that accounts for the vast majority of brain tumors. Thus, it is important to elucidate the molecular pathogenesis and potential diagnostic and prognostic biomarkers of glioma. In the present study, gene expression profiles of GSE2223 were obtained from the Gene Expression Omnibus (GEO) database. Core modules and hub genes related to glioma were identified using weighted gene coexpression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis of differentially expressed genes (DEGs). After a series of database screening tests, we identified 11 modules during glioma progression, followed by six hub genes (RAB3A, TYROBP, SYP, CAMK2A, VSIG4, and GABRA1) that can predict the prognosis of glioma and were validated in glioma tissues by qRT-PCR. The CIBERSORT algorithm was used to analyze the difference of immune cell infiltration between the glioma and control groups. Finally, Identification VSIG4 for immunotherapy response in patients with glioma demonstrating utility for immunotherapy research.
Phytochemical Investigation of Egyptian Riverhemp: A Potential Source of Antileukemic Metabolites
Authors: Abdelgawad Shimaa M. , Hetta Mona H. , Ibrahim Mohamed A. , Balachandran Premalatha , Zhang Jin , Wang Mei , Eldehna Wagdy M. , Fawzy Ghada A. , El-Askary Hesham I. , Ross Samir A.
Published: August 2022

As part of our research group’s continuous efforts to find alternative treatments for cancer, the aqueous ethanol extract of Sesbania sesban L. Merr. (SS, Egyptian riverhemp) demonstrated an antileukemic activity against K562 cell line. Bioguided fractionation of SS leaves hydroethanolic extract resulted in the isolation of one new compound (33) named as hederatriol 3-O-β-D-glucuronic acid methyl ester as well as 34 known compounds. Seven compounds ((34), (22), (20), (24), (21), (19), and (35)) showed high antiproliferative effects (IC50 = 22.3, 30.8, 31.3, 33.7, 36.6, 37.5, and 41.5 μM, respectively), while four compounds ((32), (5), (29), and (1)) showed milder activities (IC50 = 56.4, 67.6, 83.3, and 112.3 μM, respectively). A mechanistic study was further carried out on a molecular genetics level against several transcription factors signaling pathways that are incorporated in the incidence of cancer. The results showed that compounds (22) and (21) demonstrated a specific inhibition of Wnt pathway (IC50 = 3.8 and 4.6 μM, respectively), while compound (22) showed a specific inhibition of Smad pathway (IC50 = 3.8 μM). Compound (34) strongly altered the signaling of Smad and E2F pathways (IC50 = 5 μM). The bioactive metabolites were further investigated in silico by docking against several targets related to K562 cell line. The results showed that compounds (22) and (34) exhibited a strong binding affinity towards topoisomerase (docking score = −7.81 and −9.30 Kcal/Mole, respectively). Compounds (22) and (34) demonstrated a strong binding affinity towards EGFR-tyrosine kinase (docking score = −7.12 and −7.35 Kcal/Mole, respectively). Moreover, compound (34) showed a strong binding affinity towards Abl kinase (docking score = −7.05 Kcal/Mole).
Development of Music Online Teaching System Based on Distributed Database Search Technology
Authors: Shun Wang
Published: August 2022

With the continuous advancement of Internet technology, the traditional music teaching model has slowly evolved from offline to online. Nowadays, music platforms no longer focus solely on music but are supplemented by some social functions. Under the current huge market demand, in order to meet the individual needs of different music users, more and more music platforms continue to perform technological updates. Various music platforms have sprung up continuously. Although they provide users with a variety of options, at the same time, users must download corresponding applications to experience each music platform, which brings a certain degree of confusion to users. In order to solve such problems, this article implements a download-free music online education system through PWA. Aiming at the shortcomings of traditional database search engine systems, this article studies the implementation methods of distributed database search engines. First, a search engine architecture based on a cloud database is proposed so that the existing database search engine system can be implemented in the HBase distributed database, thereby improving the efficiency of the search engine. Secondly, a new data preprocessing method is proposed, which improves the data interaction technology between the relational database and the HBase distributed database, and simplifies the project development framework. Subsequently, this paper proposes a multiuser detection algorithm, which can determine duplicate data entries by calculating keyword similarity to improve the accuracy of search results. This paper promotes the development of music teaching by integrating a multiuser detection algorithm and distributed database search technology and applying it to the construction of music teaching online system.
[Retracted] Clinical Application of Spiral CT Reconstruction Imaging in Patients with Tracheal Stenosis before Anesthesia
Authors: Dai Shijie , Yao Yingying , Xia Daolin
Published: August 2022

In order to solve the problem of CT reconstruction imaging, this paper presents a study on the clinical application of preanesthesia in patients with tracheal stenosis. Patients with tracheal stenosis and multislice spiral CT virtual endoscopy (CTVE) were diagnosed, and their application effects were analyzed. Methods. 60 patients with tracheal stenosis were selected for clinical observation. The patients were given tracheal stenosis examination and multislice spiral CT virtual endoscopy. The examination results of the two groups were compared and analyzed by statistical methods. Results. There was no significant difference in the detection rate, sensitivity, accuracy, and specificity between the two groups (P > 0.05). Conclusion. Multislice spiral CT virtual endoscopy combined with a fiberoptic bronchoscope for clinical diagnosis of tracheal stenosis can complement each other. Combined use can effectively improve the detection consistency, and is safe and reliable. It can be used as an effective means for the diagnosis of tracheal stenosis.
Severe Bullous Pemphigoid Onset after Jugular Catheter Placement in a Patient on Hemodialysis
Authors: Jacobs Lucas , Feoli Francesco , Bruderer Pascal , Top Semra , Grozdev Ivan , Cubilier Edouard , Collart Frederic
Published: August 2022

Pruritus is highly prevalent in the dialysis population. Its etiology however remains often unclear with uremic pruritus primarily suspected unless compelling evidence of another cause. Although bullous pemphigoid (BP) is considered idiopathic, there are growing data in the literature on BP provoked by different factors, such as medications or surgical procedures. These secondary dermatoses are described as rather mild conditions and more frequent in the elderly Caucasian. We herein describe a newly dialyzed African man of 76 years old, treated by a sulfonylurea such as an antidiabetic drug, who developed a severe BP after jugular catheter placement.
Immunochemotherapy - A Missed Opportunity for Metastasized Malignant Melanoma? Reporting a Therapeutic Success with Checkpoint Inhibitor Rechallenge after Cytotoxic Immuno-Priming in a Heavily Pretreated Patient
Authors: Kiderlen Til R. , Delmastro Nicola , Jobst Friedemann , de Wit Maike
Published: August 2022

Treatment of metastasized malignant melanoma still has very limited therapeutic options. After exhaustion of immuno-checkpoint inhibition (ICI) and potentially targeted therapy, no promising alternatives are currently available. We report on an 83-year-old patient suffering from disseminated metastatic melanoma who showed an almost complete response to ICI following chemotherapy, after repeated failure of different regimens including two nonresponsive regimens of ICI. The presented outcome suggests a cytotoxic immuno-priming, facilitating a response to prior nonresponsive ICI. As this concept has not been established until now for malignant melanoma, in contrast to multiple other cancer entities, our case report corroborates previous evidence and therefore suggests a new treatment option, which should be researched further.
Protein Loss in Peritoneal Effluent: Different Meaning for 24-h versus PET Samples
Authors: Malho Guedes Anabela , Calças Marques Roberto , Domingos Ana Teresa , Laranjo Céu , Silva Ana Paula , Rodrigues Anabela
Published: August 2022

Introduction: Quantification of peritoneal protein loss (PPL) may be expressed according to a timely collection (24-h measurement or 4-h PET assessment) and as a concentration. The aim of this study was to compare the quantification methods of 24-h and 4-h collections. Methods: This study included 81 prevalent peritoneal dialysis patients. Demographics and clinical and bioelectrical impedance features were registered. PPL was measured (4-h PET and 24-h results) and peritoneal protein clearance was calculated. A linear regression model was performed. Results: Age and continuous ambulatory peritoneal dialysis (compared to cycler) were positively associated with greater PPL on 24-h collections. Neither cardiovascular disease, hypertension, diabetes nor the comorbidity Charlson Index was significantly associated with PPL. There was a consistent univariable relationship with D/P creatinine, whichever sampling method was used. Only 24-h measurements of PPL correlated with body composition variables. In multiple linear regression analysis, D/P creatinine association with PPL stands out. On the other hand, 24-h determinations (in grams or clearance) were associated with overhydration. PET protein quantification was associated with peritoneal creatinine clearance. Discussion/Conclusion: Different methods sign different pathophysiological pathways. PET protein loss quantification should be regarded as a marker of peritoneal membrane intrinsic permeability. Measurements of a 24-h sample might be closer to patients’ clinical status and prognosis, signalizing opportunities for therapy intervention.
Bowel Perforation in a Patient with Hepatocellular Carcinoma during Lenvatinib Treatment
Authors: Mizokami Ken , Watanabe Akiko , Yamaguchi Eriko , Saito Akira
Published: August 2022

We present a case of severe bowel perforation during lenvatinib treatment for advanced hepatocellular carcinoma. Although the Hartmann’s procedure was performed, the patient died 48 h after the operation. The histopathological findings suggested that lenvatinib was involved in the etiology of bowel perforation in this case.
Ischemic Necrosis of the Gastric Remnant Treated Successfully Using Total Remnant Gastrectomy
Authors: Hara Tetsuhiro , Tokumoto Noriaki , Shimbara Kensuke , Adachi Tomohiro , Hanaki Hideaki , Shimomura Manabu , Aoki Yoshiro , Kano Mikihiro , Kohashi Toshihiko , Hihara Jun , Funakoshi Mahito , Kaneko Mayumi , Mukaida Hidenori
Published: August 2022

Distal gastrectomy (DG) with lymph node dissection is considered as the standard treatment for gastric cancer. Ischemic necrosis of the gastric remnant is a rare but serious complication of DG that requires careful consideration for early diagnosis and treatment to lower the associated mortality rate. A 71-year-old male presented to our hospital with hyperglycemia and was evaluated for suspected diabetes. The patient’s medical history was otherwise unremarkable. Computed tomography (CT) revealed a thickening of the stomach wall, with follow-up esophagogastroduodenoscopy revealing type 3 gastric cancer in the greater curvature of the antrum. Biopsy specimen confirmed a pathological diagnosis of mucinous adenocarcinoma, with a clinical diagnosis of cT3N0M0, cStageIIB. An open DG with Billroth I reconstruction was performed, without incident. On postoperative day 1, the patient developed a high fever, abdominal pain, and elevated white blood cell count (12,200/μL). On postoperative day 2, his C-reactive protein level increased to >30 mg/dL. CT revealed an edematous thickening of the stomach wall, with poor mucosal enhancement of the remnant stomach and thinning of the anastomosis wall, with air nearby. Emergency surgery was performed for suspected leakage. Intraoperative findings showed no evidence of leakage. Intraoperative endoscopy revealed a necrotic gastric remnant, and we performed a total remnant gastrectomy with Roux-en Y reconstruction. The patient was discharged in a stable condition, 25 days after the first surgery. Although ischemic necrosis of the gastric remnant is a rare complication, its possibility should be carefully considered after DG, for early diagnosis and treatment.
Intramural Hematoma and Retroperitoneal Hematoma Following a Routine Colonoscopy: An Uncommon Complication of a Common Procedure
Authors: Jalal Ayesha , Khatiwada Pratik , Shoreibah Mohamed , Dauer Ryan
Published: August 2022

Colonoscopy is used worldwide for screening colon cancer. Routine colonoscopy is considered a safe procedure with relatively fewer adverse events. We present a case of intracolonic and retroperitoneal hematoma following a routine colonoscopy. This case highlights an uncommon life-threatening complication of a common procedure. A 50-year-old female presented with abdominal pain and syncopal episode following an uneventful screening colonoscopy. CT abdomen revealed intracolonic and retroperitoneal hematoma. This eventually led to exploratory laparotomy and right hemicolectomy after failure of conservative management. Clinicians need to be aware of the potentially life-threatening complications associated with colonoscopy for overall safety of colonoscopy.
Removal of Subfoveal Massive Hard Exudates through an Intentional Macular Hole in Patients with Diabetic Maculopathy: A Report of Three Cases
Authors: Iwane Yukako , Imai Hisanori , Yamada Hiroko , Sotani Yasuyuki , Oishi Mariko , Nakamura Makoto
Published: August 2022

Recently, good postoperative visual acuity has been reported using surgical removal of hard exudates (HEs) through an intentional macular hole (iMH). We report 3 cases of subfoveal HE secondary to diabetic maculopathy (DM) treated with HE removal via an iMH. Pars plana vitrectomy (PPV) was performed in three eyes of 3 patients with subfoveal HE secondary to DM. In all eyes, after PPV, internal limiting membrane (ILM) peeling of the lower half was performed within the range of papilla diameter 2 centered on the fovea, leaving the upper half for subsequent inverted ILM flap technique. Then, by grabbing the inner layer of the fovea using ILM forceps, an iMH was created. The HE was then flushed from the iMH with a balanced salt solution as much as possible. Finally, the inverted ILM flap technique was performed using the upper half of the ILM that was left during the previous maneuver. At the end of the surgery, the eyes were flushed with 50 mL of 20% sulfur hexafluoride (SF6) after the fluid-air exchange of the vitreous cavity. After surgery, HE was adequately removed, iMH was completely closed, and visual acuity improved in all eyes. This surgical procedure did not cause a central scotoma but rather improved the central sensitivity of the visual field in all eyes. No serious surgery-related complications occurred. In conclusion, HE removal via an iMH hole can be one of the treatment options for patients with subfoveal HE secondary to DM.
Kikuchi-Fujimoto Disease in a Crohn’s Patient
Authors: Shaikh Danial H. , Ghazanfar Haider , Sandhu Tegveer , Hussain Ali Naqqi Ul , Patel Harish
Published: August 2022

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, focal, self-limiting disease. We report a unique case of KFD in a patient with coexisting Crohn’s disease. Our patient is a 23-year-old African American female with a past medical history significant for Crohn’s disease who presented to the clinic because of a painless lump over the right side of the neck for the past 3 weeks. On physical examination, the patient was found to have enlarged nontender right cervical lymph nodes from levels 2 to 4. An excisional biopsy of the right neck lymph node was done which revealed necrotizing histiocytic lymphadenitis, favoring a diagnosis of KFD. Over the course of the next 2 months, her lymphadenopathy got resolved. This is the first case of KFD in a patient with Crohn’s Disease. Lymphoma remains a feared adverse outcome for immunomodulatory drugs, thus necessitating their cessation upon signs of lymphadenopathy. Our case highlights the importance of a detailed workup in order to access the underlying cause of the lymphadenopathy so that the immunomodulatory drugs can be resumed in these patients.
Judicialização da assistência hospitalar negada por planos e seguros de saúde no Estado de São Paulo
Authors: Cruz Joana Indjaian , Lima Leon Faria de
Published: August 2022

Este artigo sistematizou a legislação e as alterações da regulamentação das coberturas dos planos de saúde entre 1998 e 2020 e analisou 2.845 acórdãos do Tribunal de Justiça do Estado de São Paulo no ano de 2018, relacionados a negativas de coberturas reclamadas por consumidores de planos de saúde. As coberturas hospitalares, dentre as quais destacam-se as cirurgias e internações, foram o principal objeto das demandas, compondo 41% do total estudado. A maioria das coberturas hospitalares excluídas ou negadas não constavam no rol de procedimentos e eventos em saúde da Agência Nacional de Saúde Suplementar. A regulamentação dessa agência, com destaque para o rol de procedimentos e eventos em saúde, relaciona-se com a exclusão de coberturas hospitalares por planos de saúde, sendo utilizada como argumento para a defesa judicial da negativa de cobertura pelas operadoras de planos de saúde, em conjunto com as previsões contratuais. O Tribunal de Justiça do Estado de São Paulo, na maioria das vezes (80% dos casos estudados), garantiu a cobertura hospitalar demandada, fundamentando as decisões prioritariamente no Código de Defesa do Consumidor, na Jurisprudência do Tribunal de Justiça do Estado de São Paulo, nas súmulas do tribunal e na Lei n. 9.656/1998 (Lei dos Planos de Saúde). Conclui-se que o Poder Judiciário, quando provocado, tende a reconhecer o direito dos consumidores ao acesso às coberturas assistenciais, muitas vezes em contraposição à regulação setorial pela Agência Nacional de Saúde Suplementar.
Benzeção como recurso em saúde: estudo transversal com idosos moradores de área rural
Authors: Jesien Stephanie , Marmitt Luana Patrícia , Meucci Rodrigo Dalke
Published: August 2022

OBJETIVO Estimar a prevalência e os fatores associados à procura de benzedeiras para tratamento de problemas de saúde entre idosos residentes na área rural do município do Rio Grande-RS. MÉTODOS Estudo transversal, de base populacional com amostragem aleatória, realizado no ano de 2017. O desfecho foi analisado em três categorias (nunca usou/usou nos últimos 12 meses/usou há mais de 12 meses). Para análise dos fatores associados foi utilizada regressão logística multinomial. RESULTADOS Foram entrevistados 1.030 idosos. As prevalências da procura por benzedeira nos últimos 12 meses e há mais de 12 meses foram de 9,5% e 15,8%, respectivamente. Na análise ajustada, as características associadas à utilização de benzedeira há mais de 12 meses foram: estar na faixa etária de 80 anos ou mais e ter problemas de coluna e artrose. Seguir a religião evangélica foi identificado como fator de proteção para a utilização desse recurso. Já a procura por benzedeira no último ano esteve relacionada com a faixa etária dos 70–79 anos, seguir religiões espiritualistas, presença de doença nos últimos 12 meses, problemas na coluna e artrose e preferência por utilização de serviços de urgência e emergência. Sexo feminino permaneceu associado apenas à utilização há mais de 12 meses. CONCLUSÃO Este estudo traz uma contribuição original a um tema pouco avaliado em estudos epidemiológicos, pois o conhecimento da frequência e dos determinantes da busca por esse tipo de terapia popular, pode ser utilizado para melhorar a qualidade e o acesso aos serviços de saúde oferecidos à população idosa de áreas rurais.
Erring on the Side of Indigenous peoples
Authors: Ojeda-Zavala Nicolas
Published: August 2022

The recognition of indigenous peoples’ right to participate in decision-making is one of the most important developments in international law, enabling them to use their knowledge and influence the adoption of measures that could affect them. However, due to a narrow approach to indigenous participation, states often disregard this knowledge, thus moving forward without having full certainty about potential effects on indigenous peoples’ environment and livelihood. In this context, there is a role for the precautionary principle, by which states must avoid the materialisation of non-negligible harm in situations of scientific uncertainty. Yet, this principle has been shaped by a conventional understanding of ‘science’, inadequate to deal with these risks and uncertainties involving socio-cultural aspects beyond conventional sciences. Considering this, I argue that the adoption of effective precautionary measures requires relying on another relevant form of knowledge, traditional knowledge, expanding this notion of ‘science’ and strengthening indigenous peoples’ participatory rights.
Six new species of Cladosporium associated with decayed leaves of native bamboo (Bambusoideae) in a fragment of Brazilian Atlantic Forest
Authors: COSTA PRICILA P. , ROSADO ANDRÉ W. C. , PEREIRA OLINTO L.
Published: August 2022

The Atlantic Forest has the greatest diversity of plants per hectare, and it is considered the main center of bamboo biodiversity in the world. Studies on bambusicolous fungi are scarce and concentrated in temperate regions. Cladosporium is one of the largest genera of dematiaceous hyphomycetes fungus and their adaptation to different environments allows them to have a broad lifestyle. Currently, this genus has been taxonomically and phylogenetically elucidating with the help of extensive polyphasic analyzes. This study aimed to characterize 17 Cladosporium isolates associated with decayed leaves of three bamboo species at a fragment of the Brazilian Atlantic Forest, namely “Parque Estadual da Serra do Brigadeiro”, Minas Gerais state, Brazil. Phylogenetic studies revealed that all isolates belong to the C. cladosporioides species complex. Six new Cladosporium species were found and named herein as C. aulonemiae, C. bambusicola, C. benschii, C. brigadeirensis, C. chusqueae and C. pseudotenuissimum. This study contributes with several taxonomic novelties for knowledge about the diversity of the C. cladosporioides species complex.