bluuebunny/crossref_metadata_2025 huggingface dataset:
Free Wi-Fi Calling Without Sim and Internet
Authors: Karsarpe Mahesh
Published: March 2023

Private businesses began to rely more and more on telephone communication as the contemporary telephone networks took shape. A lot of people choose to launch their own business. so that they could manage calls coming from within the company. Voice telephony on mobile devices is provided at a fee using a service provider like GSM, or at a lesser cost using an IP service provider. The purpose of this project is to build and implement a telephony programme that employs WLAN (Wireless Local Area Network) or Peer-to-Peer (P2P) WIFI as a free method of communication between mobile phones. Phone numbers will be converted into IP addresses by the 3CX Phone System software using a correlation between the most recent address books made available on mobile devices.The system will permit voice communications from users. The current setup does not support conference calls or call waiting, only one call per connection. We describe various security services that are appropriate to VoIP and make the case that end-to-end authentication and encryption ought to be offered by default.
Humic acid catalyzed solvent-free green protocol for synthesis of thioamide
Authors: Mukherjee Suvodip , Mitra Bijeta , Pariyar Gyan Chandra , Pal Sandipan , Deb Mayukh , Ghosh Pranab
Published: March 2023

An environmentally sustainable, green synthesis of thioamide through multi-component reaction (MCR) of aldehyde, amine and sulphur catalyzed by Humic acid in solvent-free condition at 100 oC. The key features of this protocol are use of humic acid, a greener, easily recyclable, easily available and almost unexplored catalyst and circumvention of noxious solvents that amplify the scope of the reaction. The proposed protocol also possesses tolerance to aromatic as well as aliphatic aldehydes and amines comprising variety electron donating and withdrawing functional groups.
Enhancing Cancer Treatment and Understanding Through Clustering of Gene Responses to Categorical Stressors
Authors: Hadi Christopher El , Hilal George , Aoun Rita
Published: March 2023

Cancer cells have unique metabolic activity in the glycolysis pathway compared to normal cells, which allows them to sustain their growth and proliferation. Therefore, inhibiting glycolytic pathways may provide a promising therapeutic approach to cancer treatment. In this first-of-its-kind study, we analyzed the genetic responses of cancer cells to stressors, particularly drugs that target the glycolysis pathway. Gene expression data for experiments on different types of cancer cells were retrieved from the Gene Expression Omnibus and expression fold-change was then clustered after dimensionality reduction. We identified four response clusters, the first and third are affected the most by anti-glycolytic drugs, consisting mainly of squamous and mesenchymal tissues, showing higher mitotic inhibition and apoptosis. Drugs acting on several glycolytic targets at once resulted in such responses. The second and fourth clusters were relatively unaffected by the treatments, succumbing the least to glycolysis inhibitors. These clusters are mainly gynecological and hormone-sensitive, with drugs acting on hexokinases mainly inducing this response. This study highlights the importance of analyzing the molecular states of cancer cells to identify potential targets for personalized cancer treatments and to improve our understanding of the disease.
Nutrient Uptake in Supplemented Substrate by Oyster Mushroom
Authors: Jesus Gabriel , Lavoranti Osmir , SCHAEFER Gilmar , OLIVEIRA Gabriel Dias , SILVA Ricardo Scheffer Andrade , Cuquel Francine
Published: March 2023

Spent mushroom substrate (SMS) can be a good alternative for the supplementation of the Oyster mushroom substrate, replacing the cereal bran normally used. Therefore, the objective was to evaluate the production of Pleurotus ostreatus supplemented with Lentinula edodes’ SMS, through the nutritional analysis of the substrate. Wheat straw was used as substrate and supplemented with rice bran (RB) or SMS in 0%, 7%,15% and 30%. Ca, K, Mg, Mn, Zn, Cu and Fe contents of the cultivation substrates (before and after harvest) were determined. Mycelial growth (cm²/day), mycelial time colonization (days), number of clusters, number of pileus, average clusters weight (g), pileus lenght (cm) and width (cm), productivity (1st, 2nd and 3rd flush) (%), biological efficiency (%) of mushrooms were evaluated. Results indicated mycelial growth was higher when the substrate was supplemented regardless of the source. The same tendency followed for second flush (%), third flush (%), average clusters weight (g), productivity (%) and biological efficiency (%). The proportions of 15% of SMS achieved the highest biological efficiency. All the nutrients analyzed had a decrease in their concentrations. The only nutrients that showed differences in absorption according to each substrate used were Ca, K and Mn. This difference was also noticed according to the type of supplement, in which substrates supplemented with SMS had greater absorption of Ca, while substrates supplemented with RB absorbed more K. It is noteworthy that the mineral contents in substrates directly affect the production of P. ostreatus, which implies that the SMS are a nutritional source in terms of mineral contents and thus can be recycled and used to replace rice bran and produce Oyster mushroom.
Rivaroxaban treatment for asymptomatic venous thromboembolism: Insights from the J’xactly Study
Authors: Migita Shohei , Okumura Yasuo , Fukuda Ikuo , Nakamura Mashio , Yamada Norikazu , Takayama Morimasa , Maeda Hideaki , Yamashita Takeshi , Ikeda Takanori , Mo Makoto , Yamazaki Tsutomu , Hirayama Atsushi
Published: March 2023

Background: An established treatment strategy against asymptomatic pulmonary embolism (PE) or deep vein thrombosis (DVT) remains lacking in Japan; therefore, in this study, we clarify the characteristics and outcomes of symptomatic compared to asymptomatic patients with PE (n = 419) or DVT (n = 597).
Methods: This prospective, multicenter sub-analysis of the J’xactly study in Japan included 1,016 patients (mean age, 68; 41% male) with venous thromboembolism (VTE) treated with rivaroxaban.
Results: Asymptomatic PE patients (47% of PE patients) were more likely to have active cancer and asymptomatic proximal DVT at lower severity than symptomatic PE patients, despite no differences in age, sex, or the proportion receiving intensive 30 mg/day-rivaroxaban. Patients with asymptomatic DVT (34% of DVT patients) were older, had higher rates of female sex, active cancer, and distal DVT, and received shorter, less intense rivaroxaban treatment. Incidences did not differ between asymptomatic and symptomatic PE patients for recurrent symptomatic VTE (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.22–1.62; P = 0.31) or major bleeding (HR, 0.68; 95% CI, 0.20–2.33; P = 0.58), nor between asymptomatic and symptomatic DVT patients for recurrent symptomatic VTE (HR, 0.56; 95% CI, 0.23–1.40; P = 0.21) and major bleeding (HR, 1.47; 95% CI, 0.54–3.97; P = 0.45).
Conclusions: The real-world composite adverse event rate for treatment with rivaroxaban, as physician-adjusted for dose and duration, was similar between asymptomatic and symptomatic patients regardless of the presence of PE or DVT, suggesting a favorable safety profile for potential rivaroxaban treatment for asymptomatic VTE.
Autoimmune diseases presenting with IgG4 related lesions at atypical sites - a tale of two cases with literature review
Authors: Baisya Ritasman , Yerram Keerthivardhan
Published: March 2023

Introduction IgG4RD overlapping with clinically overt autoimmune diseases (Rheumatoid arthritis ( RA) or anti-phospholipid syndrome (APS) is rarely reported in the literature. Here we report a tale of two cases with known autoimmune diseases – RA and primary APS presented with IgG4-related lesions involving unusual sites – oesophagus and right atrium of the heart respectively Case – The first case was a known RA presented with dysphagia, imaging suggestive of encasing mass in oesophagus causing stricture , biopsy was suggestive of IgG4RD. The second patient was a known case of primary APS presented with breathlessness, imaging revealed right atrial mass with histopathology was suggestive of IgG4RD . Both patients had significant improvement after starting steroid. Discussion – A few cases of known RA presenting with IgG4 mass is reported in literature though RA patients are frequently found to have increased number of IgG4 in their sera. Primary APS with IgG4 lesion is extremely uncommon. Though a several case reports or series are published regarding oesophageal and cardiac IgG4 related lesions, such lesions in the background of known autoimmunity is first described by us . Conclusion – This is the first case series of two cases with IgG4 related lesions in atypical site in known autoimmune diseases .
New strategies for the new environment. Stowaway feather star on crab Hyas sp. - Spitsbergen (Arctic)
Authors: Deja Kajetan , Dragańska-Deja Katarzyna , Węsławski Jan Marcin
Published: March 2023

This publication presents a possibly never-before-recorded new behaviour, adaptations of the filter feeder crinoid using Hyas crabs in the inner, heavily loaded with suspension runoff part of the Spitsbergen fjords. The work used a 16-hour and 45-minute time-lapse sequence showing the decompositions of Atlantic Cod. During the exposure, apart from typical organisms such as carrion crustaceans, crabs and starfish, several individuals of crinoids were observed. One of the crinoids attached its cirri to the edge of the platform for most of the exposure. The remaining individuals observed attached to the carapace of Hyas crabs for 6 hours 55 minutes. It was also found, basis on analysis of the video material from 202 locations examined in the summer season between 2015-2020 using a drop camera, additionally two locations with a positive occurrence of a comatulida. Both locations in the Ekmanfjorden and in the interior of the Vanmijenfjorden are areas under the strong influence of a glacier or a glacial river. So far, the occurrence of crinoids has been found mainly in locations outside of the influence of turbid waters from fjords. We believe that the new observation of the comatulida behaviour will allow it to colonize new regions gradually exposed by the retreating glaciers.
MSRHNN:Multidimensional Social Relation under Heterogeneous Neural Network for Recommendation
Authors: Millette Rhydian , Pinard Eulalia , Blaise Breanna , Vanier Callan
Published: March 2023

With the growing popularity of mobile smart devices and the availability of 4G and 5G networks, social recommendation systems have become a hot research topic for industrial applications. Social networks among users are built through social information, which can improve collaborative filtering and solve cold start and sparsity problems. Graph convolutional networks have been widely used to represent the interactions and structural relationships among entities, but the exponential increase of the domain introduces a new problem. In this paper, we propose a multidimensional social relation under heterogeneous neural network (MSRHNN). By embedding historical evaluations, various social networks constituting different dimensions, the attention integration of different social networks on user preferences is achieved. A static graph encoder is used to process the node representation of each heterogeneous graph at different time steps, which includes the node attribute information and edge information, to capture the changing feature information of the nodes in all time steps of the dynamic graph, and to obtain an effective node representation at each time step. The goal of the heterogeneous dynamic graph neural network is to capture the changing node representations of the same nodes and different nodes in the graph network at different time steps, in order to better perform the task of node classification in dynamic graphs. In this paper, the model of heterogeneous dynamic graph neural network is verified from data, and experiments show that heterogeneous dynamic graph neural network outperforms other representation learning methods.
Utopija u filozofiji Gordane Bosanac
Authors: Skuhala Karasman Ivana
Published: March 2023

U ovom članku donosim pregled razmišljanja o utopiji, hrvatske filozofkinje Gordane Bosanac (Varaždin, 1936. – Zagreb, 2019.). Ona se pitanjem utopije bavi u svoje dvije knjige Utopija i inauguralni paradoks. Prilog filozofsko-političkoj raspravi (2005.) i Ime utopije. Jugoslavensko samoupravljanje kao izigrani projekt emancipacije (2015.). Druga knjiga svojevrstan je nastavak prve. Radi boljeg razumijevanja i pregleda prvo iznosim teze iz njezine prve, a zatim i iz druge knjige. Osim što Bosanac u svojim knjigama obrađuje pojam utopije, ona jednako temeljito obrađuje pojmove inauguracija, inauguralni paradoks, socijalizam, komunizam i samoupravljanje. Počevši od samog pojma utopije, ona čitatelja vodi od Thomasa Morea, preko drugih renesansnih utopista, zatim Marxa i Engelsa, Blocha, pa sve do anti-utopizma.
Neka moguća pitanja i zadatci informacijskih i komunikacijskih znanosti
Authors: Špiranec Sonja , Kalebić Gracijano
Published: March 2023

U ovom se radu raspravlja o nekim mogućim pitanjima i zadacima od osobite važnosti za informacijske i komunikacijske znanosti. Tematiziraju se etička i tehnologijska pitanja, raspravlja se o ulozi i odgovornosti informacijskih i komunikacijskih intelektualaca, antropološkom pitanju informacijskih i komunikacijskih znanosti, političkoj ekonomiji, propagandi i odnosima s javnošću, korporacijama i postpolitici, praktičkim osnovama informacijskih i komunikacijskih znanosti, stvaralaštvu, utopijskoj dimenziji informacijskih i komunikacijskih znanosti, knjižnicama i tržištu, izazovima obrazovanja informacijskih i komunikacijskih stručnjaka te pogledu u budućnost. Izložena razmatranja i promišljanja o krucijalnim pitanjima i zadaćama informacijskih i komunikacijskih znanosti vode prema zaključku o potrebi njihove humanizacije, koja implicira odustajanje od nekritičkog usvajanja afirmacijskih diskursa o pitanjima informacijskog društva i kritički odnos prema cjelini života i društva.
Problem iznimnog (izvanrednog) stanja
Authors: Sunajko Goran
Published: March 2023

Rad polazi od analize Schmittova ključnog djela Politička teologija nakon 100 godina od njegova objavljivanja. U njemu je njemački filozof prava formulirao koncept političke teologije koji označuje odnos iznimnog stanja i decizionizma kao oblika pravno-političkog mišljenja. Doprinos rada ogleda se u naglasku na važnosti dvojakoga razumijevanja pojma iznimnog stanja: u prvom redu kao pojma iznimke koji fundira filozofiju prava i pravnu teoriju, a u drugom kao pojma iznimnog (izvanrednog) stanja koji označuje ustavnu kategoriju upravljanja državom u situacijama opasnosti. Schmitt će inzistirati na tomu da pitanje iznimnoga stanja nije pitanje pukog stanja nužde ili izvanrednog stanja, već širi filozofijsko-pravni koncept temeljen na metafizičkom porijeklu odluke. Suveren tako nije onaj koji odlučuje »u«, već »o« iznimnom stanju, a to znači da ga on, sukladno decizionističkom modelu, tek uspostavlja. Kontroverzno Schmittovo djelo rijetko je koga ostavilo ravnodušnim pa su ga podržavali kako desni, tako i lijevi politički teoretičari i filozofi, a danas se mora iznova promisliti kao upozorenje na opasnost koncepta iznimnog (izvanrednog) stanja koje se sve više pojavljuje u političkom fokusu.
Excitation transfer in disordered spin chains with long-range exchange interactions
Authors: Palaiodimopoulos Nikolaos E. , Kiefer-Emmanouilidis Maximilian , Kurizki Gershon , Petrosyan David
Published: March 2023

We examine spin excitation or polarization transfer via spin chains
with long-range exchange interactions in the presence of diagonal and
off-diagonal disorder. To this end, we determine the mean localization
length of the single-excitation eigenstates of the chain for various
strengths of the disorder. We then identify the energy eigenstates of
the system with large localization length and sufficient support at the
chain boundaries that are suitable to transfer an excitation between the
sender and receiver spins connected to the opposite ends of the chain.
We quantify the performance of two transfer schemes involving weak
static couplings of the sender and receiver spins to the chain, and
time-dependent couplings realizing stimulated adiabatic passage of the
excitation via the intermediate eigenstates of the chain which exhibits
improved performance.
Trophic classification and assessment of lake health using indexing approach and geostatistical methods for sustainable management of water resources
Authors: Auddy Nilabhra , Kumar Rai Atul , Chatterjee Sharmistha , Pobi Krishnendu , Dutta Subhankar , Nayek Sumanta
Published: March 2023

This study aims to analyse the spatio-temporal trends in water quality, trophic state, and organic contamination of an alpine lake in the Darjeeling Himalaya through field investigations and to portray a comprehensive picture using multivariate analysis. Analysed water parameters have shown notable seasonal variations and were within the acceptable range for inland surface water. Water quality index (WQI) and organic pollution index (OPI) values have displayed ‘poor’ to ‘heavily polluted’ status in the pre-monsoon season, with marginally better conditions during the post-monsoon studies. Trophic state indices (TSIs) values revealed ‘eutrophic to highly eutrophic’ conditions during the investigation period. The results of the PCA have depicted three major determining factors (i.e., anthropogenic contribution, geogenic or weathering, and seasonal/climatic factors) that control the overall pollution level in the lake water system. The current study can potentially be a benchmark for assessing and undertaking management and restoration measures for this nascent alpine ecosystem.
Editorial
Authors: De Araújo Marta Maria
Published: March 2023

.
Exploring Scoring Function Space: Developing Computational
Models for Drug Discovery
Authors: Bitencourt-Ferreira Gabriela , Villarreal Marcos A. , Quiroga Rodrigo , Biziukova Nadezhda , Poroikov Vladimir , Tarasova Olga , de Azevedo Junior Walter F.
Published: March 2023

Background:

The idea of scoring function space established a systems-level
approach to address the development of models to predict the affinity of drug molecules
by those interested in drug discovery.

Objective:

Our goal here is to review the concept of scoring function space and how to
explore it to develop machine learning models to address protein-ligand binding affinity.

Methods:

We searched the articles available in PubMed related to the scoring function
space. We also utilized crystallographic structures found in the protein data bank (PDB)
to represent the protein space.

Results:

The application of systems-level approaches to address receptor-drug interactions
allows us to have a holistic view of the process of drug discovery. The scoring function
space adds flexibility to the process since it makes it possible to see drug discovery
as a relationship involving mathematical spaces.

Conclusion:

The application of the concept of scoring function space has provided us
with an integrated view of drug discovery methods. This concept is useful during drug
discovery, where we see the process as a computational search of the scoring function
space to find an adequate model to predict receptor-drug binding affinity.
Carbonic Anhydrase 4 Serves as A Novel Prognostic Biomarker and
Therapeutic Target for Non-Small Cell Lung Cancer: A Study Based on
TCGA Samples
Authors: Xu Bo , Lou Yang , Xu Xiaoyi , Li Xianshuai , Tian Xin , Yu Zhaonan , Chen Xianguo
Published: March 2023

Background:

Carbonic anhydrase 4 (CA4) is a member of a large family of zinc metalloenzymes
that catalyze the reversible hydration of carbon dioxide and was found to have low expression
in non-small cell lung cancer (NSCLC). However, the specific role of CA4 in NSCLC and
the underlying mechanisms remain unknown.

Methods:

The bioinformatic analysis on lung adenocarcinoma (LUAD) and lung squamous cell
carcinoma (LUSC) datasets downloaded from The Cancer Genome Atlas (TCGA) database was
performed. We found that CA4 expression was lower in tumors than that in normal tissues, which
were verified by Real-time PCR. Lower CA4 levels were significantly associated with higher T
stages in LUAD and LUSC cohorts. Multivariate analysis showed that CA4 is an independent
prognostic factor for NSCLC. Furthermore, the expression of CA4 also correlated with immune infiltration
and drug sensitivity.

Results:

Ectopic expression of CA4 decreased NSCLC cell proliferation in vitro by CCK-8 assay.
CA4 caused G0/G1 cell cycle arrest by cell experiments. Mechanistic studies found that CA affects
the cell cycle and inhibits cell proliferation by downregulating the expression of CDK2.

Conclusion:

The present findings highlight the role of CA4 in NSCLC and identify CA4 as a potential
novel diagnostic and prognostic biomarker for the treatment of NSCLC.
Chronic Administration of Methamphetamine Aggravates
Atherosclerotic Vulnerable Plaques in Apolipoprotein E Knockout
Mice Fed with a High-cholesterol Diet
Authors: Cui Xiaoxue , Gao Bo , Yu Yijun , Gu Ye , Hu Liqun
Published: March 2023

Background:

It has been observed previously that chronic methamphetamine
(METH) administration could upregulate neuropeptide Y (NPY) expression and promote
atherosclerotic formation in apolipoprotein E knockout (ApoE-/-) mice fed with a normal
cholesterol or high diet and NPY might be involved in the pathogenesis of METHinduced
atherogenic effects through NPY Y1 receptor pathway. Vulnerable coronary
atherosclerotic plaque (VP) is a critical pathological finding responsible for the acute
coronary syndrome (ACS). In this study, we explored whether METH abuse could
aggravate the formation of VP in ApoE-/- mice fed with high cholesterol diet.

Objective:

The purpose of this study was to observe if chronic METH administration
could aggravate vulnerable plaque (VP) formation in ApoE-/- mice fed with a highcholesterol
diet

Methods:

Male ApoE-/- mice fed with a high-cholesterol diet were intraperitoneally
injected with normal saline (NS) or 8 mg/kg/day METH (M8) for 24 weeks. Body weight
was monitored from baseline to 24 weeks at 2 weeks intervals. After 24 weeks of
treatment, plasma lipid variables were measured. Movat's staining and immunohistochemical
staining were performed on frozen sections of the aortic roots to calculate
VP percentage and intraplaque hemorrhage (IPH) percentage and detect expression of
NPY, vascular endothelial growth factor (VEGF), and CD31. In vitro, the expressions of
Y2R, VEGF, and CD31 were detected by immunofluorescence staining in aortic
endothelial cells incubated with PBS, 100μM METH, 10nmol NPY, or 100μM METH plus
10nmol NPY for 12 hours.

Results:

The CD31 positive area, percentage of IPH, VP, and the expressions of NPY
and VEGF were significantly increased in the M8 group than in the NS group. In vitro,
the expressions of Y2R, VEGF, and CD31 were significantly increased in the
METH+NPY group than in the PBS, METH, and NPY groups and these effects could be
blunted by treatment with a Y2R antagonist or DPPIV inhibitor.

Conclusion:

Chronic METH administration could aggravate VP in ApoE-/- mice fed with
a high-cholesterol diet, possibly through upregulating vascular NPY and VEGF
expression and promoting angiogenesis and vessel rupture in atherosclerotic plaques.
Our findings indicated that increased VP formation might contribute to the development
of acute coronary syndrome post-chronic METH abuse by activating DPPIV/NPY/Y2R
pathway.
Epigenetics of Fear, Anxiety and Stress – Focus on Histone Modifications
Authors: Ell Marco A. , Schiele Miriam A. , Iovino Nicola , Domschke Katharina
Published: March 2023

Fear-, anxiety- and stress-related disorders are among the most frequent mental disorders.
Given substantial rates of insufficient treatment response and often a chronic course, a better understanding
of the pathomechanisms of fear-, anxiety- and stress-related disorders is urgently warranted.
Epigenetic mechanisms such as histone modifications - positioned at the interface between the biological
and the environmental level in the complex pathogenesis of mental disorders - might be highly informative
in this context. The current state of knowledge on histone modifications, chromatin-related
pharmacology and animal models modified for genes involved in the histone-related epigenetic machinery
will be reviewed with respect to fear-, anxiety- and stress-related states. Relevant studies, published
until 30th June 2022, were identified using a multi-step systematic literature search of the Pub-
Med and Web of Science databases. Animal studies point towards histone modifications (e.g.,
H3K4me3, H3K9me1/2/3, H3K27me2/3, H3K9ac, H3K14ac and H4K5ac) to be dynamically and
mostly brain region-, task- and time-dependently altered on a genome-wide level or gene-specifically
(e.g., Bdnf) in models of fear conditioning, retrieval and extinction, acute and (sub-)chronic stress.
Singular and underpowered studies on histone modifications in human fear-, anxiety- or stress-related
phenotypes are currently restricted to the phenotype of PTSD. Provided consistent validation in human
phenotypes, epigenetic biomarkers might ultimately inform indicated preventive interventions as well
as personalized treatment approaches, and could inspire future innovative pharmacological treatment
options targeting the epigenetic machinery improving treatment response in fear-, anxiety- and stressrelated
disorders.
Pyridazinone-substituted Benzenesulfonamides Demonstrate Inhibition of
Monoamine Oxidase
Authors: Petzer Anél , Shetnev Anton , Efimova Julia , Korsakov Mikhail , Filimonov Sergei , Petzer Jacobus P.
Published: March 2023

Background:

The monoamine oxidase (MAO) enzymes are important drug targets. Inhibitors
of MAO-A and MAO-B have been used to treat the symptoms of depression and Parkinson’s disease.

Methods:

A series of seventeen pyridazinone-substituted benzenesulfonamides was synthesized and evaluated
as potential inhibitors of human MAO-A and MAO-B. This study is a continuation of our interest in
the pharmacological activities of sulfonamide compounds.

Results:

Among the compounds evaluated, only 10 and 18 demonstrated appreciable inhibition of MAOB
with IC50 values of 2.90 and 4.36 μM, respectively. None of the benzenesulfonamides inhibited the
MAO-A isoform. Potential binding orientations and interactions of 10 and 18 with the active site of
MAO-B were investigated by computational approaches.

Conclusion:

Although these potencies are modest, this study is the first report on MAO inhibition by this
class of compounds. Active MAO-B inhibitors may serve as leads for the future discovery of therapeutic
agents for neurodegenerative disorders, such as Parkinson’s disease.
Clinical Trial Authorisation: A Final Look Back to Better Appraise the
New European Regulation
Authors: Vignot Stéphane , Guyader Gaelle , Salomon Valérie , Vella Philippe , Yoldjian Isabelle , Maison Patrick , Ratignier-Carbonneil Christelle
Published: March 2023

The implementation of the new European Clinical Trial Regulation on 31 January 2022,
is a major step to promote clinical research in Europe. The French National Agency for Medicines
and Health Products Safety (ANSM) proposes to share some key aspects of the preparation for the
application of the Regulation initiated in 2017 and to discuss shared indicators that should be
considered to monitor clinical trials opportunities on a territory with regards to access to innovation
for patients and attractiveness for sponsors. New criteria based on the time from the first request
for authorisation to the first inclusion could be of particular interest to appraise the implementation
of the European Clinical Trial Regulation.
A Computed Tomography-based Radiomics Analysis of Low-energy
Proximal Femur Fractures in the Elderly Patients
Authors: Mohammadi Seyed Mohammad , Moniri Samir , Mohammadhoseini Payam , Hanafi Mohammad Ghasem , Farasat Maryam , Cheki Mohsen
Published: March 2023

Introduction:

Low-energy proximal femur fractures in elderly patients result from factors,
like osteoporosis and falls. These fractures impose high rates of economic and social costs. In
this study, we aimed to build predictive models by applying machine learning (ML) methods on
radiomics features to predict low-energy proximal femur fractures.

Methods:

Computed tomography scans of 40 patients (mean ± standard deviation of age = 71 ± 6)
with low-energy proximal femur fractures (before a fracture occurs) and 40 individuals (mean ±
standard deviation of age = 73 ± 7) as a control group were included. The regions of interest, including
neck, trochanteric, and intertrochanteric, were drawn manually. The combinations of 25
classification methods and 8 feature selection methods were applied to radiomics features extracted
from ROIs. Accuracy and the area under the receiver operator characteristic curve (AUC) were
used to assess ML models' performance.

Results:

AUC and accuracy values ranged from 0.408 to 1 and 0.697 to 1, respectively. Three
classification methods, including multilayer perceptron (MLP), sequential minimal optimization
(SMO), and stochastic gradient descent (SGD), in combination with the feature selection method,
SVM attribute evaluation (SAE), exhibited the highest performance in the neck (AUC = 0.999,
0.971 and 0.971, respectively; accuracy = 0.988, 0.988, and 0.988, respectively) and the trochanteric
(AUC = 1, 1 and 1, respectively; accuracy = 1, 1 and 1, respectively) regions. The same
methods demonstrated the highest performance for the combination of the 3 ROIs’ features (AUC
= 1, 1 and 1, respectively; accuracy =1, 1 and 1, respectively). In the intertrochanteric region, the
combination methods, MLP + SAE, SMO + SAE, and SGD + SAE, as well as the combination of
the SAE method and logistic regression (LR) classification method exhibited the highest performance
(AUC = 1, 1, 1 and 1, respectively; accuracy= 1, 1, 1 and 1, respectively).

Conclusion:

Applying machine learning methods to radiomics features is a powerful tool to predict
low-energy proximal femur fractures. The results of this study can be verified by conducting
more research on bigger datasets.
Comparative Study for the Absorption of Carbon Dioxide in
Aqueous Amine Solvents for Enhanced Loading
Authors: Sood Akash , Thakur Avinash , Ahuja Sandeep Mohan
Published: March 2023

Aims:

The current study aimed to investigate the CO2 absorption capacity of the aqueous
alkanolamine, including primary, secondary, tertiary, and sterically hindered amines and polyamines,
i.e., monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA) and 2-
amino-2-methyl-1-propanol (AMP), tetraethylenepentamine (TEPA), triethylenetetramine (TETA), 3-
(Methylamino)propylamine (MAPA), and diethylenetriamine (DETA) at 40, 60, and 80°C at 1.1 bar.

Methods:

An increase in reaction temperature caused a decrement in CO2 loading across the board
for all solvents. The trend of CO2 loading was TEA < MEA < DEA < AMP < MAPA < DETA <
TETA < TEPA at 40 ºC, TEA < DEA < MEA < AMP < MAPA < DETA < TETA < TEPA, at
60ºC and TEA < DEA < AMP < MEA < MAPA < DETA < TETA < TEPA at 80ºC.

Results:

The results indicated that TEPA has great potential to be utilized as an energy-efficient
and non-corrosive solvent for CO2 capture since it has outperformed all other aqueous amine solvents
in this present study. Furthermore, the CO2 loading of sterically hindered amine (AMP) at the
same temperature was found to be higher than primary, secondary, and tertiary amines. Heat of
absorption (Δ Η abs) was also determined to gauge the energy requirement to regenerate absorbents
for cyclic loading from an economic viewpoint.

Conclusion:

DETA has the highest Δ Η abs = 84.48 kJ/mol. On the contrary, the long-chain tertiary
amine TEA resulted in the least Δ Η abs = 40.21 kJ/mol, among all other solvents. Whereas the sterically
hindered amine (AMP) was observed to possess mid-range Δ Η abs, i.e., 58.76 kJ/mol.
Among all selected solvents, polyamines showed higher Δ Η abs than other conventional amines
pertaining to the precedence of TEA<AMP<DEA< MEA<TETA<TEPA<MAPA<DETA.
Vibration monitoring of railway bridge pier and probability of scour occurrence
Authors: Kawabe D.
Published: March 2023

Abstract. This study aims to propose a way to estimate probability of scour occurrence of a railway bridge pier by means of ambient vibration monitoring. A remote real-time scour monitoring scheme utilizing ambient vibrations of piers is considered as an alternative method for conventional impact test. A stochastic approach to deal with uncertainty of estimated frequencies caused by relatively poor signal to noise of the ambient vibration is discussed. The probability distribution of the identified frequencies in a normal condition is modeled with a stable distribution, and the probability of scour occurrence is estimated using a logistic curve. The validity of proposed method is verified using monitoring vibration data during swollen river water period in the past.
Aeroacoustic energy harvesting using relaxor ferroelectric single crystals
Authors: Schipper M.J.
Published: March 2023

Abstract. This paper reports on the use of relaxor ferroelectric single crystal for harvesting aeroacoustic energy from the floor of a structural cavity. In particular, this work examines the optimisation of the single crystal transducer geometry to maximise the energy harvested. The transducers used are 0.175 mm thick [011] poled Mn-Pb(Mg1/3Nb2/3)O3-Pb(Zr,Ti)O3 (or Mn-PMN-PZT) single crystal fibre composite (or SFC). In this study, the SFCs are bonded to the floor of an experimental cavity within a low-speed wind-tunnel with an airspeed of ~ 60 m/s. Air flowing over the cavity creates an oscillatory pressure cycle that is used as a source of harvestable energy. Detailed multiphysics modelling and parametric optimisation were performed, with model predictions well matched to wind-tunnel experimental results. In particular it is shown that, due to the cavity geometry, an SFC mounted on the cavity floor perpendicular to the wind-tunnel flow produces ~4 times more power than an SFC mounted parallel.
Data-driven models for strain-based damage identification in composite wind turbine blades
Authors: Sierra J.
Published: March 2023

Abstract. The increasing demand for renewable energy has led to the development of several wind energy projects. A rising concern is the aging of these structures that must keep their serviceability and integrity for a long lifetime. That is why recent studies have focused on monitoring systems for data extraction based on accelerometers, fiber optic sensors, and piezoelectric sensors among many other sensing technologies. One of the most promising approaches is the use of fiber-Bragg-grating-based systems taking advantage of their proven benefits such as electromagnetic immunity, low size and weight, and ability to embed numerous sensors in a single optical fiber line. However, most of the reported studies have addressed the operational assessment of the acquisition systems without further deepening the exploitation of the acquired data for structural health monitoring purposes. This work aims to data exploitation of strain measurements acquired by simulated fiber Bragg gratings (FBG) for damage identification in wind turbine blades made of composite materials. A FEM model of a 2.5-meter-long wind turbine blade with 40 virtual FBGs strain sensors was used to obtain strain data under normal operational conditions. Then, strain measurements were calculated after defining several damages to the blade. Once the data were obtained, different data processing techniques following the pattern recognition paradigm were tested comparing their performance in terms of accuracy. The results will contribute to designing real-time automatic damage identification systems using FBGs strain sensors for composite wind turbine blades.
Higher-order effects of amplitude-modulation vibro-acoustic technique for characterization thermal damages in cement-based material
Authors: Yin T.
Published: March 2023

Abstract. This paper proposes a new amplitude-modulation vibro-acoustic (AMVA) technique to detect thermal damage in pristine graphene (PRG) mortar materials. A new third-order solution for an amplitude-modulated low-frequency pump wave and a high-frequency probe wave in infinite isotropic material is presented. The solution includes higher-order sidebands generated by intrinsic and acquired nonlinearities. A nonlinear parameter is defined according to the third-order solution to assess the different levels of thermal damage. The experimental study demonstrates the sensitivity and feasibility of the AMVA technique by comparing the nonlinear parameter with the linear measurements of the ultrasonic pulse velocity (UPV) test. The results show that the proposed AMVA technique is a potential tool to detect and monitor thermal damage in cement-based structures.
An optimized asset management petri net model for railway sections
Authors: Saleh A.
Published: March 2023

Abstract. Railways are important ways of transportation that are used massively. This makes it important to create an optimized asset management model that helps in reducing its Operation and Maintenance (O&M) costs while maintaining the quality of service and safety. Reinforcement learning (RL) is an adequate model for optimizing decisions based on unrelated factors as it connects the decision to a final goal without understanding the problem details. Also, it allows for automatic policy updates without any user intervention. On the other hand, the Petri net (PN) model, which is a bipartite graph of transitions and places, are adequate to be combined with Reinforcement learning since RL actions can be directly described by the PN transitions. In addition, PNs are suitable for maintenance modeling since it can model heterogeneous information, parallel operations, and synchronization, and provide a graphical interpretation. In this study, the Petri net method is used with Reinforcement Learning to create a tool for modeling and optimizing decisions within the maintenance of railway sections while taking into account several factors.
Structural health and performance monitoring of floating cover at the western treatment plant: Our chronology
Authors: Kong W.K.
Published: March 2023

Abstract. This paper provides a historical overview of the development of a diagnostic tool and its integration with the operational characteristics of a floating cover for structural health assessment and performance monitoring in terms of biogas harvesting of the floating covers at the Western Treatment Plant, Melbourne, Australia. Large membrane-like covers used in several environmentally sensitive application contexts, including (i) floating covers for clean water reservoirs, to prevent evaporation and pollution, (ii) landfill liners to stop leakage of hazardous chemicals or harmful matter, (iii) mining applications such as heap leaching, salt evaporation ponds and tailings impoundment are high value assets. Floating covers for anaerobic reactors in wastewater treatment plants are also constructed with these membrane structures. The covers on the anaerobic lagoons at the Western Treatment Plant, west of Melbourne, Australia is a large structure whose construction and installation costs mounts to tens of millions of dollars. They are used to collect biogas emitted during the anaerobic digestion of the raw sewage beneath the cover making it an important asset from an environment standpoint. The research team were provided with an opportunity to develop a diagnostic tool to assist with the safe and efficient operation of this critical asset.
Fatigue response of conformal load bearing antenna structures
Authors: Lu S.
Published: March 2023

Abstract. Non-woven, metal-coated, carbon veil has the potential to replace copper in radiofrequency transmission lines and micro-strip antenna elements. It is of importance to characterise the mechanical properties of these veils to implement them into antenna design. These veil materials are incorporated into a dielectric substrate made from glass-fibre reinforced plastic (GFRP). This antenna system can be integrated into a load bearing composite structure enhancing its multi-functionality and will therefore be exposed to the operational loads of the primary structure. An example of such primary structure is the wing of an unmanned aerial vehicle (UAV). This paper will report on a set of investigation detailing the effects of fatigue loading on the durability and the performance of this load bearing conformal antenna system. The fatigued antenna will be subjected to a series of cantilever loading to show the performance of the conformal antenna when the fatigue-exposed antenna is subjected to quasi-static loading that is expected during normal operation of the structure.
Numerical and experimental studies on the joint performance of fastened, bonded, and hybrid thin metal joints used in aircraft structures
Authors: Ekladious A.
Published: March 2023

Abstract. Static strength of mechanically fastened, bonded, and hybrid double lap joints are investigated in this study. Aerospace grade 7075-T6 aluminium alloy was chosen for the adherend as it is a widely used primary aircraft structure material. Mechanical fasteners were arranged in square array patterns to resemble typical rivet arrangements in airframes. The aim was to compare the joint performance of three distinct joining/repairing mechanisms: purely riveted, purely bonded, and a hybrid of both rivets and adhesive bonding. Finite element analysis (FEA) verification of the riveted configuration static strength indicated accurate prediction of both joint strength and failure mode. Detailed results will be reported in the paper. This paper presents the first stage of a systematic research program assessing the damage tolerance behaviour of crack growth, and design assessment of adhesive bonded/hybrid metallic joints under static and fatigue loadings, to achieve the optimum joint design for applications.
Comparative strain survey of an aerospace structure using distributed fibre optic strain sensing technology
Authors: Natividad G.
Published: March 2023

Abstract. Significant strides have been made in non-proprietary distributed FOS technologies suitable for structural health monitoring (SHM) applications. FOSs are resistant to electromagnetic interference, corrosion, and high-strain cyclic loading while also providing significant reductions in weight and the complexity of installation when compared to conventional electrical resistance foil strain gauges (FSGs). This paper builds on previous benchmarking of proprietary distributed FOSs and demonstrates a FOS-based high-density strain measurement capability on a large aircraft structure subjected to representative flight loading.
¿Qué sabemos de las abejas sin aguijón (Hymenoptera: Apidae, Meliponini) en México?: Diversidad, Ecología y polinización
Authors: Baena-Díaz Fernanda , Chévez Estrella , Porter-Bolland Luciana
Published: March 2023

El decremento en las poblaciones naturales y manejadas de polinizadores ha situado el interés sobre el papel de los polinizadores, principalmente en el sector agrícola, por los efectos reportados en lo que se conoce como la “crisis de los polinizadores”. Dentro de los polinizadores más representativos se encuentran las abejas, y dentro de éstas, las abejas sin aguijón (Apidae: Meliponini). Estas últimas tienen gran relevancia ecológica, económica y cultural en el mundo y particularmente en México, por ser un grupo manejado desde hace cientos de años para obtención de miel y otros productos de la colmena. En esta revisión de literatura nos enfocamos en documentar lo que se sabe sobre las abejas sin aguijón en cuanto a su distribución, genética y ecología. En particular nos interesa resaltar aspectos sobre sus interacciones y los servicios ecosistémicos que proveen. Nuestro objetivo fue sintetizar la información disponible para México e identificar áreas de oportunidad en el estudio de estas abejas, con el fin de promover mejores estrategias de conservación y manejo. Encontramos que falta intensificar los estudios de este grupo para poder realizar un análisis de cómo los cambios ambientales afectan la riqueza de especies, abundancia, distribución e interacciones. Así mismo, la falta de estudios longitudinales nos impide conocer la magnitud del declive de estos polinizadores. Finalmente, proponemos incluir en los estudios de ecología y genética de abejas sin aguijón un enfoque de participación social, la cual puede proveer información muy valiosa sobre abejas nativas en México.
Optical studies of quasi-two-dimensional organic metals (EDT-TTF)-=SUB=-4-=/SUB=-[Hg-=SUB=-3-=/SUB=-I-=SUB=-8-=/SUB=-]-=SUB=-1-x-=/SUB=- (x=0 and 0.027) --- comparative analysis within the "phase phonons" model
Authors: Petrov B. V.  , Volkov M. P.
Published: March 2023

Reflection spectra of quasi-two-dimensional organic conductors (EDT-TTF)4[Hg3I8]1-x, are considered, which, depending on the composition, demonstrate different phase transitions: x=0.027 --- metal-superconductor with Tc= 8.1 K, x=0 --- metal-insulator at a temperature of T<35 K. The polarized reflection spectra were analyzed using the "phase phonons" model, which takes into account the electronic-vibrational interaction. Using this model, the optical functions of both compounds were adequately described and the energy parameters of the π--electron system were obtained. It is shown that for the compound with x=0.027 these parameters change monotonically with temperature, while for x=0 they show a jump at the phase transition temperature. A comparison of the model parameter Delta (the value of the periodic potential) for crystals with different stoichiometric coefficients x=0 and x=0.027 was carried out and an assumption was made about the dependence of the periodic potential on the average charge of one EDT molecule. Keywords: organic conductors, EDT-TTF, layered structure, reflection spectra, "phase phonons" model, electronic-vibrational interaction, optical conductivity.
Spectral-angular characteristics of the radiation of a charged particle in the Redmond field
Authors: Kudryavtsev D. I.  , Kopytov G. F.  , Suhanov A.E.
Published: March 2023

Based on the solution of the equation of motion of a charge in an electromagnetic field, the classical theory of radiation of a relativistic charged particle linearly accelerated by a high-intensity laser pulse in the presence of a static component of the magnetic field is constructed. Solutions obtained by Kopytov G.F. and Pogorelov A.V., were used to study the spectral-angular characteristics of the radiation of a charged particle in a combination of the field of a plane monochromatic electromagnetic wave and a constant magnetic field, the so-called Redmond field. According to the calculated formulas for the radiation intensity of particles in the Redmond field, graphs of the dependence on the magnitude of the magnetic field, phase and phase-angular distributions are plotted. The Fourier transform of the intensity of the electric field of the radiation and the spectral density of the radiation of the particle in the case of linear polarization of the wave is obtained. Keywords: Redmond field, spectral-angular characteristics, charged particle, Lawson-Woodward theorem, superpower laser radiation.