bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspectos electroclínicos de la epilepsia temporal mesial
Authors: Nariño González Daniel , Lizcano Meneces Angélica , Gómez Arias Bety
Published: July 2023

Introducción: la epilepsia del lóbulo temporal mesial se considera la más frecuente de las epilepsias focales, con signos y síntomas característicos que ayudan a definir su diagnóstico.
Contenidos: dentro de su historia natural, las crisis pueden iniciar en los primeros años de vida, usualmente como episodios febriles con un periodo de remisión, para reaparecer en la adolescencia o en el adulto joven. La presentación electroencefalográfica tiene un patrón característico, con aparición de puntas y ondas agudas interictales en la región temporal anterior, por lo general unilaterales, y con actividad ictal generalmente theta en la misma localización. La causa más frecuente es la esclerosis del hipocampo. El tratamiento con medicamentos anticrisis puede controlar la epilepsia, aunque algunos casos pueden evolucionar a la farmacorresistencia, en la cual la cirugía de epilepsia está indicada, y tiene buenos resultados.
Conclusiones: esta revisión se centra en la descripción de las características electroclínicas de la epilepsia temporal mesial, para hacer un diagnóstico temprano e iniciar un tratamiento adecuado, a efectos de lograr un mejor pronóstico y una mejor calidad de vida para los pacientes con epilepsia y sus familiares.
Features of technological regulation for cardiac bioimplants
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ministry of Education and Science of Ukraine, Kyiv, Ukraine, Shchotkina N. ,   Technical University of Applied Sciences Wildau, Wildau, Germany, Palamarchuk Y. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ministry of Education and Science of Ukraine, Kyiv, Ukraine, Skorokhod I. ,   Technical University of Applied Sciences Wildau, Wildau, Germany, Dolinchuk L. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ministry of Education and Science of Ukraine, Kyiv, Ukraine, Sokol A. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ministry of Education and Science of Ukraine, Kyiv, Ukraine, Motronenko V. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ministry of Education and Science of Ukraine, Kyiv, Ukraine, Besarab A. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ministry of Education and Science of Ukraine, Kyiv, Ukraine, Frohme M. ,   Technical University of Applied Sciences Wildau, Wildau, Germany, Herzog M. ,   Technical University of Applied Sciences Wildau, Wildau, Germany
Published: July 2023

Patients with congenital heart defects and cardiovascular diseases are required new approaches to surgical intervention. The use of biological cardiac implants, which are made from the extracellular matrix, is a promising trend in modern regenerative medicine. These bioimplants can completely replace defective tissue or organs, and when manufactured with strict protocols and quality control measures, can be safe and effective for therapeutic applications. The process of manufacturing bioimplants involves various risks that need to be assessed and mitigated with ongoing monitoring and evaluation necessary to ensure the highest standards of quality. Overall, this study was successfully evaluated the requirements for introducing a new medical device into practice and created a technical file that meets all necessary documentation for certification.
Radiographic reference values of the central knee anatomy in 8–16-year-old children
Authors: Vogt Bjoern , Hvidberg Emma , Rölfing Jan Duedal , Gosheger Georg , Møller-Madsen Bjarne , Abood Ahmed A , Weyer-Elberich Veronika , Laufer Andrea , Toporowski Gregor , Roedl Robert , Frommer Adrien
Published: July 2023

Background and purpose: For correction of leg-length discrepancy or angular deformity of the lower limb in skeletally immature patients temporary or permanent (hemi-)epiphysiodesis can be employed. These are reliable treatments with few complications. Recently, radiographic analysis of treatment-related alterations of the central knee anatomy gained interest among pediatric orthopedic surgeons. To date the comparison and adequate interpretation of potential changes of the central knee anatomy is limited due to the lack of defined standardized radiographic references. We aimed to establish new reference values of the central knee anatomy.Patients and methods: A retrospective analysis of calibrated longstanding anteroposterior radiographs of 254 skeletally immature patients with a chronological age ranging from 8 to 16 years was conducted. The following radiographic parameters were assessed: (1) femoral floor angle, (2) tibial roof angle, (3) width at femoral physis, and (4) femoral notch–intercondylar distance.Results: All observed radiographic parameters were normally distributed with a mean age of 12.4 years (standard deviation [SD] 2, 95% confidence interval [CI] 12.2–12.6). Mean femoral floor angle was 142° (SD 6, CI 141.8–142.9), mean tibial roof angle was 144° (SD 5, CI 143.7–144.1), mean width at femoral physis was 73 mm (SD 6, CI 72.8–73.9), and mean femoral notch–intercondylar distance was 8 mm (SD 1, CI 7.5–7.7). The estimated intraclass correlation coefficient values were excellent for all measurements.Conclusion: This study provides new radiographic reference values of the central knee anatomy for children between 8 and 16 years and we suggest considering values within the range of 2 SD as the physiological range.
IDENTIFIKASI STRUKTUR LAPISAN TANAH PADA LAHAN GAMBUT DENGAN METODE RESISTIVITAS KONFIGURASI WENNER-SCHLUMBERGER
Authors: Sapina Ega , Handayani Linda , Pebralia Jesi
Published: July 2023

Tanah gambut memiliki karakterisitik kandungan air dan kompresebilitasnya tinggi menyebabkan gambut rentan terjadi penurunan permukaan tanah ketika ada pembebanan. Penelitian ini bertujuan untuk menganalisis ketebalan lapisan tanah gambut di Desa Pandan Jaya Kecamatan Geragai Kabupaten Tanjung Jabung. Metode yang digunakan adalah metode geolistrik resistivitas konfigurasi Wenner-Schlumberger dengan sebanyak 4 lintasan pengukuran masing-masing 110 meter dengan jarak antar elektroda 10 meter. Dari hasil pengukuran resistivitas diperoleh bahwa lapisan gambut di Desa Pandan Jaya Kecamatan Geragai Kabupaten Tanjung Timur memiliki nilai resistivitas  mulai dari 5,03 Ωm hingga 130 Ωm. Dapat disimpulkan lapisan gambut pada lokasi penelitian memiliki ketebalan antara 5 m hingga 7 m.  Informasi ini sangat penting untuk pertimbangan kedalaman pondasi saat akan mendirikan bangunan di daerah tersebut.
SERUM CREATININE LEVEL IN LATE PRETERM INFANTS IN THE EARLY NEONATAL PERIOD
Authors:   Northern State Medical University, Arkhangelsk, Russia, Kiseleva L.G. , Vasilyeva S.N. ,   Perinatal Center with the Arkhangelsk Oblast Regional Clinical Hospital, Arkhangelsk, Russia, Solovieva A.S. ,   Northern State Medical University, Arkhangelsk, Russia, Borodina K.A. ,   Northern State Medical University, Arkhangelsk, Russia, Skachkova T.N. ,   Perinatal Center with the Arkhangelsk Oblast Regional Clinical Hospital, Arkhangelsk, Russia, Maikova N.V. ,   Perinatal Center with the Arkhangelsk Oblast Regional Clinical Hospital, Arkhangelsk, Russia, Pychina Y.N. ,   Perinatal Center with the Arkhangelsk Oblast Regional Clinical Hospital, Arkhangelsk, Russia
Published: July 2023

In accordance with the criteria for assessing the quality of medical care for prematurely born children, a study of serum creatinine is carried out on the first day of life. Elevated levels of the metabolite raise doubts about the advisability of prescribing a control analysis. The purpose of the study was to assess the level of serum creatinine in late preterm infants (34 to 36 weeks of gestation) in the early neonatal period for the correct interpretation of physiological changes in the blood. A retrospective cohort study of medical records was carried out, including an assessment of serum creatinine in late preterm infants on the first and on the 4th to 6th days of life. Two groups of participants were formed from 117 children: group 1 consisted of 62 premature babies with intrauterine growth restriction; group 2 included 55 premature babies with average physical development. The average creatinine level in late preterm infants varied from 85.0 (75.8; 101.6) µmol/l on the first day of life to 43.9 (28.8; 56.0) µmol/l on days 4th to 6th of life (p=0.001). Difference in creatinine level in children from G1 and G2 on the first day of life and at the end of the early neonatal period was not detected (p=0.864, p=0.104, respectively). A significant correlation was noted between the serum creatinine level in mother and child (p=0.001). The serum creatinine level in children in the first day of life is affected by the time of the day the blood sampling for analysis was taken. Thus, the average creatinine level in children at the beginning of the first day of life was 76.0 (68.4; 81.8) µmol/l and 101.6 (93.4; 110.9) µmol/l at the end of the first day of life (p=0.001). The high creatinine level in the first day of life reflects the maternal serum index with its subsequent decrease by the end of the early neonatal period which should be taken into account when assessing the postnatal adaptation of late preterm infants.
THROMBOLYTIC THERAPY IN PEDIATRIC PRACTICE: A BIBLIOGRAPHICAL REVIEW (PART 2)
Authors:   Morozov Children’s City Clinical Hospital, Moscow, Russia, Svirin P.V. ,   Hematology, Oncology and Radiation Therapy Department with the Pediatric Faculty of the Pirogov Russian National Research Medical University, Moscow, Russia, Larina L.E. ,   Propaedeutics of Children's Diseases Department with the Pediatric Faculty of the Pirogov Russian National Research Medical University, Moscow, Russia, Lavrentyevа I.N. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia
Published: July 2023

Part 2 of the Article represents published data dedicated to the thrombolytic therapy (TT) for thrombosis of various localizations in children. Options for dosing and methods of thrombolytic therapy are considered. Indications and contraindications for this method of treatment are described. information on thrombolytic therapy in newborns is provided as well. Part 1 of the Article is available at https://doi.org/10.24110/0031-403X-2023-102-3-145-150: P.V. Svirin, L.E. Larina, I.N. Lavrentyeva. Thrombolytic therapy in pediatric practice (Part 1). Pediatria n.a. G.N. Speransky. 2023; 102 (3): 145-150. DOI: 10.24110/0031-403X-2023-102-3-145-150.
MODERN VIEW ON THE ROLE OF THE INTESTINAL MICROBIOTA IN THE DEVELOPMENT OF METABOLIC DISORDERS
Authors:   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Bolotova N.V. , Cherednikova K.A. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Filina N.Yu. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Garifulina L.M. ,   Samarkand State Medical University (SSMI), Samarkand, Republic of Uzbekistan, Logacheva O.А. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia
Published: July 2023

Bibliographical review representing the modern approach to the features of the taxonomic composition of the microbiota of the gastrointestinal tract as the largest microbiome of the human body. Modern views on the relationship in the “intestine-microbiota-brain” system are given. The main theories concerning the relationship and the role of macro- and microorganisms in the formation of metabolic disorders, in particular, in the pathogenesis of obesity, are considered as well.
MENTAL HEALTH DISORDERS IDENTIFICATION IN PEDIATRIC PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS WITH CHRONIC PAIN SYNDROME
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Zubareva E.S. , Generalova D.D. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Santimov A.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Novik G.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Tamrazova O.B. ,   Department of Dermatovenereology with a course of Cosmetology of the Faculty of Continuing Medical Education with the School of Medicine of the Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Grechanyi S.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia
Published: July 2023

Mental health disorders in pediatric rheumatologists’ practice are often unrecognized and insufficiently taken into account by pediatric rheumatologists when managing patients suffering from juvenile idiopathic arthritis (JIA). The chronic pain syndrome, which complicates the course of JIA, largely has a psychosomatic basis and is associated both with the severity of mental disorders in the patients themselves and with the characteristics of parent-child relationships. The purpose of the research was to study the severity of manifestations of mental disorders, emotional regulation and parent-child relationships in pediatric patients with JIA with chronic pain syndrome in comparison with patients with acne. Materials and methods used: a single-center simultaneous study of adolescents aged 11 to 17 y/o was conducted in Oct.-Dec. 2022. Using a visual analogue scale, the severity of pain was assessed separately by the participants in the study and their parents; patients assessed their general condition, whilst the physician determined the overall assessment of the current activity of the disease. All of the participants had completed the Difficulties in Emotion Regulation Scale (DERS), Parental bonding instrument (PBI) and Strengths and Difficulties Questionnaire (SDQ) questionnaires. Results: the main group consisted of 30 suffering from JIA with chronic pain syndrome. The comparison group consisted of 40 with acne. In patients with JIA, the values in the scales “Behavioral problems” (p=0.001), “Hyperactivity” (p=0.001), “Problems with peers” (p=0.001), “Emotional detachment” (assessment of mothers and fathers, p=0.001) and “Hyper care” (assessment of mothers and fathers, p=0.001) were statistically significantly lower, whilst higher in the values for “Prosocial behavior” (p=0.026), “Awareness of own emotions” (p=0.001), “Emotional warmth” (assessment of mothers and fathers, p=0.001) and “Encouraging independence” (assessment of mothers and fathers, p=0.001). Conclusion: JIA patients with chronic pain syndrome demonstrated more favorable mental health outcomes compared to patients with acne, which is traditionally considered as a factor in the mental adjustment disorder of adolescents that negatively affects the emotional state, self-esteem and the quality of life.
AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE WITH VERY-EARLY ONSET
Authors:   N.F. Filatov Moscow City Children's Clinical Hospital of the Moscow Department of Healthcare, Moscow, Russia, Shumikhina M.V. , Chugunova O.L. ,   N.F. Filatov Moscow City Children's Clinical Hospital of the Moscow Department of Healthcare, Moscow, Russia,   Pirogov Russian National Research Medical University, Moscow, Russia, Gurevich A.I. ,   N.F. Filatov Moscow City Children's Clinical Hospital of the Moscow Department of Healthcare, Moscow, Russia
Published: July 2023

Both autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease may occur at any age starting infancy and up to adulthood. Manifestations of autosomal dominant polycystic kidney disease usually occur in adult patients with a risk of development of end-stage renal failure after the fifth decade of life. However, an increase in the number of pediatric cases of a very-early onset of the disease, in utero or during the first 18 months of life, had been registered recently, that were characterized by severe clinical manifestations which in tis turn had mimic the autosomal recessive polycystic kidney disease. The three infant cases of autosomal dominant polycystic kidney disease are observed in the Article with perinatal period features, clinical manifestations of the disease, tests’ results and its interpretation given. Children with very-early onset of autosomal dominant polycystic kidney disease are in the high-risk group for nephromegaly, severe hypertension and the early end-stage renal failure.
MORBIDITY STRUCTURE IN 14-YEARS-OLD RESIDENTS OF THE MOSCOW CITY (RUSSIA): CHECKUPS’ STUDY
Authors:   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Polishchuk A.R. , Romanova A.S. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Khaider M.Sh. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Balashov S.L. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Sevostyanov V.K. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Published: July 2023

For citation: A.R. Polishchuk, A.S. Romanova, M.Sh. Khaider, S.L. Balashov, V.K. Sevostyanov. Morbidity structure in 14-years-old residents of the Moscow City (Russia): checkups’ study. Pediatria n.a. G.N. Speransky. 2023; 102 (4): 217-218. DOI: 10.24110/0031-403X-2023-102-4-217-218.
ETIOLOGICAL FACTORS AND CLINICAL MANIFESTATIONS OF NEPHROCALCINOSIS IN CHILDREN
Authors:   National Medical Research Center for Children’s Health, Moscow, Russia, Nikolaeva R.A. , Ananin P.V. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Vashurina T.V. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Zrobok O.I. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Pushkov A.A. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Savostyanov K.V. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Fisenko A.P. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Tsygin A.N. ,   National Medical Research Center for Children’s Health, Moscow, Russia
Published: July 2023

Nephrocalcinosis can result from some of acquired causes as well as being a part of the symptomatic complex of hereditary diseases. Despite monogenic causes of nephrocalcinosis being rare they nevertheless represent a significant disease burden with early onset of symptoms and a risk for the chronic kidney disease development. The purpose of this research was to describe the etiological characteristics and clinical picture of children with nephrocalcinosis as well as to assess its progression and impact on further decline in renal function. Methods used: a retrospective-prospective cohort study of 85 children with nephrocalcinosis was conducted on the basis of the National Medical Research Center for Children’s Health (Moscow, Russia) in 2012-2023. Results: the median age of the nephrocalcinosis detection was 1.5 [0.3; 4.4] y/o. Median observation duration was 2.5 [1.0; 5.0] years. For 37 (63%) there was a causative mutation responsible for the development of the disease associated with nephrocalcinosis diagnosed. Mutations in the CYP24A1, CLCN5, AGXT and HPRT1 genes had predominated. Further nephrocalcinosis progression had no significant effect on kidney function within a 2-year follow-up. Conclusion: nephrocalcinosis may be a part of the diseases with a high risk for progression and poor renal prognosis. Early diagnosis of the nephrocalcinosis cause is important for obtaining accurate prognostic information and timely therapy initiation.
ON JULY 18, 2023 PEDIATRIC PRACTITIONERS AND SCIENTISTS IN RUSSIA AND WORLDWIDE HAVE CELEBRATED THE ANNIVERSARY OF THE EDITORIAL BOARD MEMBER WITH THE JOURNAL «PEDIATRIA» NAMED AFTER G.N. SPERANSKY, AN OUTSTANDING PEDIATRICIAN OF OUR TIME, HONORED SCIENTIST OF THE RUSSIAN FEDERATION, LAUREATE OF THE RUSSIAN FEDERATION GOVERNMENT PRIZE IN SCIENCE AND TECHNOLOGY, PRESIDENT OF THE UNION OF PEDIATRICIANS OF RUSSIA, ACADEMICIAN OF THE RUSSIAN ACADEMY OF SCIENCES, PROFESSOR LEYLA SEYMUROVNA NAMAZOVA-BARANOVA
Authors:   Russian Academy of Sciences (RAS), Moscow, Russia, Baranov A.A. , Namazova-Baranova L.S. ,   Russian Academy of Sciences (RAS), Moscow, Russia,   Union of Pediatricians of Russia, Moscow, Russia
Published: July 2023

ON JULY 18, 2023 PEDIATRIC PRACTITIONERS AND SCIENTISTS IN RUSSIA AND WORLDWIDE HAVE CELEBRATED THE ANNIVERSARY OF THE EDITORIAL BOARD MEMBER WITH THE JOURNAL «PEDIATRIA» NAMED AFTER G.N. SPERANSKY, AN OUTSTANDING PEDIATRICIAN OF OUR TIME, HONORED SCIENTIST OF THE RUSSIAN FEDERATION, LAUREATE OF THE RUSSIAN FEDERATION GOVERNMENT PRIZE IN SCIENCE AND TECHNOLOGY, PRESIDENT OF THE UNION OF PEDIATRICIANS OF RUSSIA, ACADEMICIAN OF THE RUSSIAN ACADEMY OF SCIENCES, PROFESSOR LEYLA SEYMUROVNA NAMAZOVA-BARANOVA
Electronic Information and Transaction Law, a means of information control in libraries
Authors: Nafisah Syifaun
Published: July 2023

The Ministry of Communication and Information of the Republic of Indonesia reported increased hoax news in society. Libraries as information management institutions require information control tools so that the information served complies with legal and ethical principles. Various problems often occur in libraries, such as copyright infringement and the discovery of adult content in children’s collections. The Law on libraries regulates collection management but does not explicitly stipulate what collections are permitted and prohibited. This study aims to find out Electronic Information and Transaction Law, a means of information control in libraries. This research used the content analysis method. It used quick note techniques and member checks to obtain data. Data analysis used the Miles and Huberman model. Data validation was performed through credibility testing using triangulation, transferability, dependability, and confirmability. According to the Law, legal and ethical information do not violate Intellectual Property Rights and moral norms and protect personal rights. Information also does not contain gambling, insults, defamation, extortion, violence, or threats. Information was also not fake, misleading, or hateful news. The information must be relevant, not derived from wiretapping, and free from content prohibited by the State. Based on these findings, libraries can adopt Law Number 19 of 2016 concerning Electronic Information and Transactions as a tool for information constraints because it follows the goals of libraries to provide legal and ethical information services.
Quatro conceitos fundamentais na filosofia de G. Agamben
Authors: Pin Alex Gonçalves , Cornelli Gabriele
Published: July 2023

A partir da indagação sobre onde, no corpo do poder, técnicas de individualização e procedimentos totalizantes se tocam, o objetivo do presente artigo é explicar as noções de bando, homo sacer e máquina segundo G. Agamben. Existe, pois, um centro no qual o duplo vínculo político encontra sua razão de ser, a saber, a inflexão entre soberania e governo que a máquina governamental - conceito que também é explicado – produz, e que consiste em que se a exceção torna possível à soberania intervir sobre o governo, a glória torna possível que o governo se articule com a soberania.
Palavras-chave: Agamben; Homo sacer; Máquina; Bando; Campo.
Geometric, landmark-guided technique reduces tissue trauma, surgery time, and subjective difficulty for canine peripheral lymphadenectomies: an educational crossover study
Authors: Worden Natalie J. , Bertran Judith , Reynolds Penny S. , Chase Ellis C. , Crews Chiquitha D. , Ham Kathleen , de Mello Souza Carlos H. , Regier Penny J. , Adin Christopher A. , Maxwell Elizabeth A.
Published: July 2023

OBJECTIVE

To compare the effect of a geometric, landmark-guided lymphadenectomy (LL) approach to peripheral lymph nodes (LNs) on successful LN identification, surgical time, tissue trauma, and ease of LN identification compared to standard lymphadenectomy (SL) and methylene blue–guided lymphadenectomy (MBL).

SAMPLE

18 adult, mixed-breed canine cadavers operated on by 7 veterinarians and 5 fourth-year veterinary students between July 23 and October 12, 2022.

METHODS

Participants were provided standardized, publicly available materials regarding the anatomy and surgical techniques for SL of 3 peripheral lymphocentrums: superficial cervical, axillary (ALN), and superficial inguinal (SILN). Participants performed the 3 SLs unilaterally on canine cadavers. Thereafter, they were randomly assigned to 2 crossover groups: MBL and LL. All dissections were separated by at least 2 weeks for each participant. Primary outcome measures included successful LN identification, surgical time, tissue trauma scores, and subjective difficulty.

RESULTS

Successful LN identification was highest with LL (86%) compared to SL (69%) and MBL (67%). Subjective difficulty scores were reduced with LL for SILN dissections. Tissue trauma scores were reduced when using LL for ALN and SILN compared to MBL and SL. Time to LN identification was reduced for ALN with LL. No significant differences were observed between MBL and SL, or for the superficial cervical dissections.

CLINICAL RELEVANCE

Peripheral lymphadenectomies are time consuming and difficult for veterinarians in early stages of surgical training. Little surgical guidance is provided within current literature. Geometric, landmark-guided lymphadenectomies may improve LN identification success and reduce surgical time, tissue trauma, and procedure difficulty, which could encourage their clinical application.
Oral voriconazole therapy in cats with histoplasmosis yielded mild side effects and a favorable outcome
Authors: Easterwood Loren F. , Harkin Kenneth R. , Rankin Amy J.
Published: July 2023

OBJECTIVE

Infection by Histoplasma organisms most commonly results in disseminated systemic infection in cats. Relapse during therapy with itraconazole and fluconazole has been reported. The aim of this study was to report the clinical response, duration of therapy, side effects, and outcome in cats with histoplasmosis that were treated with voriconazole.

ANIMALS

6 client-owned cats.

CLINICAL PRESENTATION

Medical records were reviewed of cats with confirmed histoplasmosis that presented to the Kansas State University Veterinary Health Center and received voriconazole therapy (n = 6 cats).

RESULTS

4 cats were switched to voriconazole from fluconazole (n = 2), itraconazole (1), or both (1), and 2 cats received voriconazole as initial therapy. Median starting dosage was 3.51 mg/kg PO every 72 hours. Two cats required a change in dosing interval from every 72 hours to every 96 hours due to hyporexia (n = 2) and an elevated ALT (1). Remission was documented in all 6 cats with a median time to a negative urine antigen of 256 days (range, 94 to 494 days).

CLINICAL RELEVANCE

Voriconazole therapy in 6 cats with histoplasmosis yielded mild side effects and a favorable outcome. Reported dosages provide a feasible alternative to daily dosing for owners of feline patients.
On uniform dichotomy in mean of stochastic skew-evolution semiflows in Banach spaces
Authors: Fülöp Tímea Melinda Személy
Published: July 2023

In this paper we consider three concepts of uniform dichotomy in mean for stochastic skew-evolution semiflows: uniform exponential dichotomy in mean, uniform polynomial dichotomy in mean and uniform h- dichotomy in mean. Some characterizations of these notions and connections between these concepts are given. The obtained results can be considered generalizations to the dichotomy case of the results from [29].
Price calculation of wooden bariatric beds
Authors: Hitka Miloš , Lorincová Silvia , Kajanová Jana , Štarchoň Peter , Sydor Maciej
Published: July 2023

In the field of interior and furniture, the pursuit of comfort has always been based on the anthropometric dimensions of the user. When optimizing the dimensions of the bed for the needs of today’s population, we start from the forecasted values of the relevant body dimensions, i.e. height and weight. Based on previous research, we can conclude that the anthropometric dimensions of the adult Slovak population after reaching the age of adulthood have increased statistically significantly by approx. 4.5–5% since the last measurements in 1987, from the point of view of the body growth process. In connection with the aforementioned findings, it is necessary for furniture companies producing bed furniture to adjust their calculation procedures for price formation depending on the needs of users, in order to forecast their financial situation. The goal of the work is to determine the cost increase for bariatric respondents, based on the determined dimensions of the wooden bed compared to a standard manufactured bed, and to determine the calculation formula for single-piece production. The results show that increasing the dimensions of the bed will increase the total costs by approximately 70%.
Identification the 2013 Curriculum Teacher's Book to Determine the Character Values of Class X Students on Circular Motion Material
Authors: Astalini* Astalini , Darmaji Darmaji , Kurniawan Dwi Agus , Sinaga Feliza Paramitha , Azzahra Miftahul Zannah , Triani Elza
Published: July 2023

The character of school students is currently in the declining category. This is due to the lack of emphasis on the time of the learning process and affects the level of success of the functions and objectives of national education. This study aims to determine the characters that are not embedded in the physics learning process for class X material for circular motion. The research method used is a qualitative method with the type of documentation research. The researcher uses a documentation study because the subject used is a 2013 curriculum teacher's book for class X circular motion. After studying the circular motion material, it is known that there are 18 characters that must be instilled during the physics learning process. However, these 18 characters are not fully embedded because there are some characters that are missing and will have a continuous negative impact on students. Due to the imperfection of this research, in the future, in the textbook of physics learning teacher class X on Circular Motion in the 2013 curriculum and its subsequent development, more attention should be paid to the character of students so that all these characters are fulfilled in order to create a good generation
Blended Learning Program Based on Multiple Representations: Needs Analysis to Stimulate Complex Problem Solving and Reduce Learning Loss
Authors: Azizah Munadhirotul , Herlina* Kartini , Abdurrahman Abdurrahman , Himawan Nur Arviyanto
Published: July 2023

Various complex problems arise along with the increasingly massive development of science and technology in the 21st century. Special skills are needed to survive and adapt to a complex environment and demand various problems to be solved. This study aimed to determine the need for developing multiple representations-based blended learning programs to stimulate complex problem-solving (CPS) and reduce learning loss. This study uses a qualitative descriptive method to provide an overview of the implementation of CPS in high schools and the learning loss during lessons during the Covid-19 pandemic. This research was conducted in July 2022. The data source was obtained using a non-test technique in the form of an open questionnaire. The subjects in this study were 13 physics teachers and 25 students spread across 4th provinces in Indonesia, including Lampung, DIY, Central Java and West Java. The data analysis technique is the Milles Hubberman analysis technique carried out continuously until the data is saturated. Data analysis involves three steps, data reduction, data presentation, and concluding/verification. Study result show that CPS has yet to be fully implemented in physics learning in high schools. Learning during the Covid-19 pandemic was ineffective and maximal, which resulted in most students experiencing setbacks in learning and a decrease in academic progress (learning loss). Therefore, developing a blended learning program based on multiple representations is necessary to stimulate complex problem-solving and reduce learning loss
The Contribution of Communication and Digital Literacy Skills to Critical Thinking
Authors: Amin* Astuti Muh. , Adiansyah Romi , Hujjatusnaini Noor
Published: July 2023

The contribution of communication and digital literacy skills to critical thinking in biology are rarely explored. The present study employed a correlational research design to determine how communication and digital literacy skills contributed to students’ critical thinking. In this study, communication and digital literacy skills served as the predictor variables, whereas critical thinking served as the criterion variable. Fourth semester students from Tadris Biology department at IAIN Ternate in North Maluku made up the research sample. Essay questions, questionnaires, and observation sheets were used to collect data. Research results show that communication skills and digital literacy simultaneously and significantly affect critical thinking skills. The study’s findings proved that communication skills and digital literacy contribute to critical thinking skills as much as 34.93% and 29.67%, respectively. These findings indicate that educators need to incorporate components of communication skills and digital literacy into their instruction in order to enhance students’ critical thinking skills.
Knowledge and Practice of Foot Self-Care Among Diabetic Patients in National Guard Primary Care in Riyadh
Authors: Eissa Abdullah , Albakri Sarrah , Haikel Kholoud , Alilaj Muath , Kattan Safanah , Lahsah Amnah
Published: July 2023

Objective: This study aimed to evaluate the level of knowledge and practice of foot self-care in diabetic patients in Primary care at National Guard hospital, Riyadh, Saudi Arabia.
Methods: This cross-sectional study was conducted among diabetic patients attending the three biggest primary healthcare centers of the National Guard Health Affairs in Riyadh, Saudi Arabia (ISKAN clinic, HCSC, and NGCSC). The patients were asked to fill a self-administrated questionnaire that investigated demographics, knowledge, inspection, and practice.
Results: Among 390 diabetic patients, 74.1% had type 2 diabetes, 6.4% had foot ulcers, and 23.1% received training on diabetic care. The knowledge score was 10.86 ± 1.66, whereas practice score was 20.2 ± 3.5. The mean score of knowledge was significantly affected by education level (p < 0.001), whereas the mean score of practice was significantly varied regarding gender (p < 0.001), education level (p-value = 0.001), occupation (p < 0.001), duration of diabetes (p-value = 0.001), and treatment (p-value = 0.001).
Conclusion: Diabetic patients in this study had a good level of knowledge regarding foot self-care, whereas the practice was acceptable but not optimum.
СТУДЕНТСЬКА АУДИТОРІЯ МИХАЙЛА ГРУШЕВСЬКОГО ФІЛОСОФСЬКОГО ФАКУЛЬТЕТУ ЛЬВІВСЬКОГО УНІВЕРСИТЕТУ: СКЛАД ТА ДИНАМІКА
Authors: ТЕЛЬВАК Віталій , ЖУРАВЛЬОВ Святослав , ВЛАДИГА Ольга
Published: July 2023

Анотація. Мета статті полягає у з’ясуванні кількісних характеристик, динаміки та національного складу студентської аудиторії М. Грушевського. Методологічне підґрунтя становить міждисциплінарний підхід. Особливий акцент зроблено на структурно-функціональному системному аналізі історіографічних фактів і порівняльно-історичному методі, виходячи з принципів об’єктивності й історизму. Наукова новизна статті полягає у спробі комплексного аналізу студентської аудиторії М. Грушевського. Висновки. Відзначено, що студентські каталоги філософського факультету Львівського університету постають найбільш вагомим джерелом для з’ясування особливостей науково-педагогічної праці М. Грушевського у галицьку добу його життя. Важливість цього документа полягає в тому, що завдяки його інформаційному потенціалу питання, в обговоренні яких раніше домінувала емоційно-спекулятивна складова, тепер отримали фактологічне підґрунтя для всебічного історіографічного аналізу. Так, здобута на підставі опрацювання каталогів інформація дає підставу переконливо атестувати М. Грушевського як популярного викладача не тільки серед української, але й польської і єврейської молоді. Більшість її представників стали помітними діячами того часу, популяризуючи чи трансформуючи отримані на студентській лаві історичні знання. Також вдалося з’ясувати національну та гендерну специфіку студентської аудиторії українського професора, відтворити різноплановість його дидактичних пропозицій, простежити фреквенцію відвідуваності різних курсів тощо. Отже, саме завдяки опрацьованим студентським каталогам М. Грушевський постає авторитетним і діяльним представником львівської університетської корпорації.
Approximating Weakly Preferred Semantics in Abstract Argumentation through Vacuous Reduct Semantics
Authors: Blümel Lydia , Thimm Matthias
Published: July 2023

We consider the recently introduced vacuous reduct semantics in abstract argumentation that allows the composition of arbitrary argumentation semantics through the notion of the reduct. We show that by recursively applying the principle of vacuous reduct semantics we are able to cover a broad range of semantical approaches. Our main result shows that we can recover the weakly preferred semantics as the unique solution of a fixed point equation involving an infinite application of the vacuous reduct semantics based only on the very simple property of conflict-freeness. We also conduct an extensive study of the computational complexity of the recursive application of vacuous reduct semantics, which shows that it completely covers each level of the polynomial hierarchy, depending on the recursion depth.
Tractable Explaining of Multivariate Decision Trees
Authors: Carbonnel Clément , Cooper Martin C. , Marques-Silva Joao
Published: July 2023

We study multivariate decision trees (MDTs), in particular,

classes of MDTs determined by the language

of relations that can be used to split feature space.

An abductive explanation (AXp) of the classification

of a particular instance, viewed as a set of feature-value

assignments, is a minimal subset of the instance

which is sufficient to lead to the same decision.

We investigate when finding a single AXp is

tractable. We identify tractable languages for real,

integer and boolean features. Indeed, in the case

of boolean languages, we provide a P/NP-hard dichotomy.
Streamlining Input/Output Logics with Sequent Calculi
Authors: Ciabattoni Agata , Rozplokhas Dmitry
Published: July 2023

Input/Output (I/O) logic is a general framework for reasoning about conditional norms and/or causal relations. We streamline Bochman’s causal I/O logics via proof-search-oriented sequent calculi. Our calculi establish a natural syntactic link between the derivability in these logics and in the original I/O logics. As a consequence of our results, we obtain new, simple semantics for all these logics, complexity bounds, embeddings into normal modal logics, and efficient deduction methods. Our work encompasses many scattered results and provides uniform solutions to various unresolved problems.
Property Directed Reachability for Planning Revisited
Authors: Clifton Ava , Gretton Charles
Published: July 2023

Property Directed Reachability (PDR) is a relatively new SAT-based search paradigm for classical AI planning. Compared to earlier SAT-based paradigms, PDR proceeds without unrolling the system transition function, and therefore without having the underlying procedure reason about potentially computationally expensive multi-step formulae. By maintaining a queue of obligations - i.e., a state at a timestep - and knowledge about what is possible at each planning step, PDR iteratively evaluates whether an obligation can be progressed by one step towards the goal. We develop and evaluate two new distributed PDR algorithms for planning, and additionally implement serial and portfolio PDR algorithms for planning. We are the first to consider distributed PDR for planning and the first to consider PDR based on incremental SAT solving in that setting. Our first new algorithm, PS-PDR, evaluates many obligations independently in parallel using a pool of incremental SAT workers. PS-PDR is unique amongst distributed PDR algorithms in centrally maintaining a single queue of obligations, enabling an efficient focused search compared to a PDR portfolio. Our second new algorithm, PD-PDR, sequences subproblems according to the compositional structure of the concrete problem at hand. Subproblems are solved independently in parallel, with a concrete plan obtained by combining subproblem plans. Our experimental evaluation exhibits strong runtime gains for both new algorithms in both satisfiable and unsatisfiable planning benchmarks.
Mathematical Foundations for Joining Only Knowing and Common Knowledge
Authors: Cramer Marcos , Pollaci Samuele , Bogaerts Bart
Published: July 2023

Common knowledge and only knowing capture two intuitive and natural notions that have proven to be useful in a variety of settings, for example to reason about coordination or agreement between agents, or to analyse the knowledge of knowledge-based agents. While these two epistemic operators have been extensively studied in isolation, the approaches made to encode their complex interplay failed to capture some essential properties of only knowing. We propose a novel solution by defining a notion of μ-biworld for countable ordinals μ, which approximates not only the worlds that an agent deems possible, but also those deemed impossible. This approach allows us to define a multi-agent epistemic logic with common knowledge and only knowing operators, and a three-valued model semantics for it. Moreover, we show that we only really need biworlds of depth at most ω²+1. Based on this observation, we define a Kripke semantics on a canonical Kripke structure and show that this semantics coincides with the model semantics. Finally, we discuss issues arising when combining negative introspection or truthfulness with only knowing and show how positive introspection can be integrated into our logic.
Run-Based Semantics for RPQs
Authors: David Claire , Francis Nadime , Marsault Victor
Published: July 2023

RPQs (regular path queries) are an important building block of most query languages for graph databases. They are generally evaluated under homomorphism semantics; in particular only the endpoints of the matched walks are returned.

However, practical applications often need the full matched walks to compute aggregate values. In those cases, homomorphism semantics are not suitable since the number of matched walks can be infinite. Hence, graph-database engines adapt the semantics of RPQs, often neglecting theoretical red flags. For instance, the popular query language Cypher uses trail semantics, which ensures the result to be finite at the cost of making computational problems intractable.

We propose a new kind of semantics for RPQs, including in particular simple-run and binding-trail semantics, as a candidate to reconcile theoretical considerations with practical aspirations. Both ensure the output to be finite in a way that is compatible with homomorphism semantics: projection on endpoints coincides with homomorphism semantics. Hence, testing the emptiness of result is tractable, and known methods readily apply. Moreover, simple-run and binding-trail semantics support bag semantics, and enumeration of the bag of results is tractable.
How to Manage a Budget with ATL+
Authors: Demri Stéphane , Rönnholm Raine
Published: July 2023

We study the alternating-time temporal logic ATL+ enriched with one resource (written ATL+(1)) extending ATL+ with the possibility to manage a budget.

We propose a game-theoretic semantics via the introduction of two evaluation

games so that the compositional semantics is captured by strategies in the games.

We show that the model-checking problem for ATL+(1) is in PSpace and we identify

several non-trivial fragments that can be solved in PTime. By-products of our investigations include also a simplified Pspace decision procedure for

resource-free ATL+, an effective way to synthesize constraints in

a version of ATL+(1) with parameters and a PSpace bound to solve an energy game

with one counter whose objectives are LTL formulae of temporal depth one.
Revising Boolean Logical Models of Biological Regulatory Networks
Authors: Aleixo Frederico , Knorr Matthias , Leite João
Published: July 2023

Boolean regulatory networks are used to represent complex biological processes, modelling the interactions of biological compounds, such as proteins or genes, with each other and with other substances in a cell. Creating and maintaining computational models of these networks is crucial for comprehending corresponding cellular processes, as they allow reproducing known behaviours and testing new hypotheses and predictions in silico. In this context, model revision focuses on validating and (if necessary) repairing existing models based on new experimental data. However, model revision is commonly performed manually, which is inefficient and prone to error, and the few existing automated solutions either only apply to simpler networks or are limited in their revision process, since they may not be able to produce a solution within a reasonable time frame or miss the optimal solution. In this paper, we develop a solution for revising logical models of Boolean regulatory networks, able to find repairs that are consistent with provided, possibly incomplete experimental data, and minimal w.r.t. the differences to the original network. We show that our solution can be used to revise different real-world Boolean logical models very efficiently, surpassing a previous solution in terms of solved instances and with a considerable margin w.r.t. processing time.
Learning Hierarchical Policies by Iteratively Reducing the Width of Sketch Rules
Authors: Drexler Dominik , Seipp Jendrik , Geffner Hector
Published: July 2023

Hierarchical policies are a key ingredient of intelligent behavior, expressing the different levels of abstraction involved in the solution of a problem. Learning hierarchical policies, however, remains a challenge, as no general learning principles have been identified for this purpose, despite the broad interest and vast literature in both model-free reinforcement learning and model-based planning. In this work, we introduce a principled method for learning hierarchical policies over classical planning domains, with no supervision from small instances. The method is based on learning to decompose problems into subproblems so that the subproblems have a lower complexity as measured by their width. Problems and subproblems are captured by means of sketch rules, and the scheme for reducing the width of sketch rules is applied iteratively until the final sketch rules have zero width and encode a general policy. We evaluate the learning method on a number of classical planning domains, analyze the resulting hierarchical policies, and prove their properties. We also show that learning hierarchical policies by learning and refining sketches iteratively is often more efficient than learning flat general policies in one shot.
A Framework for Combining Entity Resolution and Query Answering in Knowledge Bases
Authors: Fagin Ronald , Kolaitis Phokion G. , Lembo Domenico , Popa Lucian , Scafoglieri Federico
Published: July 2023

We propose a new framework for combining entity resolution and query answering in knowledge bases (KBs) with tuple-generating dependencies (tgds) and equality-generating dependencies (egds) as rules. We define the semantics of the KB in terms of special instances that involve equivalence classes of entities and sets of values. Intuitively, the former collect all entities denoting the same real-world object, while the latter collect all alternative values for an attribute. This approach allows us to both resolve entities and bypass possible inconsistencies in the data. We then design a chase procedure that is tailored to this new framework and has the feature that it never fails; moreover, when the chase procedure terminates, it produces a universal solution, which in turn can be used to obtain the certain answers to conjunctive queries. We finally discuss challenges arising when the chase does not terminate.