bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility and Effectiveness Assessment of SARS-CoV-2 Antigenic Tests in Mass Screening of a Pediatric Population and Correlation with the Kinetics of Viral Loads
Authors: Lanari Marcello , Biserni Giovanni Battista , Pavoni Matteo , Borgatti Eva Caterina , Leone Marta , Corsini Ilaria , Lazzarotto Tiziana
Published: October 2021

The gold standard for diagnosis of SARS-CoV-2 infection has been nucleic acid amplification tests (NAAT). However, rapid antigen detection kits (Ag-RDTs), may offer advantages over NAAT in mass screening, generating results in minutes, both as laboratory-based test or point-of-care (POC) use for clinicians, at a lower cost. We assessed two different POC Ag-RDTs in mass screening versus NAAT for SARS-CoV-2 in a cohort of pediatric patients admitted to the Pediatric Emergency Unit of IRCCS—Polyclinic of Sant’Orsola, Bologna (from November 2020 to April 2021). All patients were screened with nasopharyngeal swabs for the detection of SARS-CoV-2-RNA and for antigen tests. Results were obtained from 1146 patients. The COVID-19 Ag FIA kit showed a baseline sensitivity of 53.8% (CI 35.4–71.4%), baseline specificity 99.7% (CI 98.4–100%) and overall accuracy of 80% (95% CI 0.68–0.91); the AFIAS COVID-19 Ag kit, baseline sensitivity of 86.4% (CI 75.0–93.9%), baseline specificity 98.3% (CI 97.1–99.1%) and overall accuracy of 95.3% (95% CI 0.92–0.99). In both tests, some samples showed very low viral load and negative Ag-RDT. This disagreement may reflect the positive inability of Ag-RDTs of detecting antigen in late phase of infection. Among all cases with positive molecular test and negative antigen test, none showed viral loads > 106 copies/mL. Finally, we found one false Ag-RDTs negative result (low cycle thresholds; 9 × 105 copies/mL). Our results suggest that both Ag-RDTs showed good performances in detection of high viral load samples, making it a feasible and effective tool for mass screening in actively infected children.
Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons
Authors: Bergström Petra , Trybala Edward , Eriksson Charlotta E. , Johansson Maria , Satir Tugce Munise , Widéhn Sibylle , Fruhwürth Stefanie , Michno Wojciech , Nazir Faisal Hayat , Hanrieder Jörg , Paludan Soren Riis , Agholme Lotta , Zetterberg Henrik , Bergström Tomas
Published: October 2021

Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis. In neonates, both viruses can cause severe, disseminated CNS infections with high mortality rates. Here, we differentiated human induced pluripotent stem cells (iPSCs) towards cortical neurons for infection with clinical CNS strains of HSV-1 or HSV-2. Progenies from both viruses were produced at equal quantities in iPSCs, neuroprogenitors and cortical neurons. HSV-1 and HSV-2 decreased viability of neuroprogenitors by 36.0% and 57.6% (p < 0.0001), respectively, 48 h post-infection, while cortical neurons were resilient to infection by both viruses. However, in these functional neurons, both HSV-1 and HSV-2 decreased gene expression of two markers of synaptic activity, CAMK2B and ARC, and affected synaptic activity negatively in multielectrode array experiments. However, unaltered secretion levels of the neurodegeneration markers tau and NfL suggested intact axonal integrity. Viral replication of both viruses was found after six days, coinciding with 6-fold and 22-fold increase in gene expression of cellular RNA polymerase II by HSV-1 and HSV-2, respectively. Our results suggest a resilience of human cortical neurons relative to the replication of HSV-1 and HSV-2.
An Overview of the Application of Viruses to Biotechnology
Authors: Varanda Carla , Félix Maria do Rosário , Campos Maria Doroteia , Materatski Patrick
Published: October 2021

Viruses may cause devastating diseases in several organisms; however, they are simple systems that can be manipulated to be beneficial and useful for many purposes in different areas. In medicine, viruses have been used for a long time in vaccines and are now being used as vectors to carry materials for the treatment of diseases, such as cancer, being able to target specific cells. In agriculture, viruses are being studied to introduce desirable characteristics in plants or render resistance to biotic and abiotic stresses. Viruses have been exploited in nanotechnology for the deposition of specific metals and have been shown to be of great benefit to nanomaterial production. They can also be used for different applications in pharmacology, cosmetics, electronics, and other industries. Thus, viruses are no longer only seen as enemies. They have shown enormous potential, covering several important areas in our lives, and they are making our lives easier and better. Although viruses have already proven their potential, there is still a long road ahead. This prompt us to propose this theme in the Special Issue “The application of viruses to biotechnology”. We believe that the articles gathered here highlight recent significant advances in the use of viruses in several fields, contributing to the current knowledge on virus applications.
A Mixed-Methods Study to Evaluate Elementary School Staff’s Acceptability, Delivery Challenges, and Communication Regarding the Implementation of School-Located Influenza Vaccination Program in Hong Kong
Authors: Liao Qiuyan , Dong Meihong , Yuan Jiehu , Lam Wendy Wing Tak , Cowling Benjamin J. , So Hau Chi , Ip Dennis Kai Ming
Published: October 2021

This was a mixed-methods study comprising a questionnaire-based survey, a qualitative study, and analysis of school newsletters to evaluate elementary school staff’s acceptability, delivery challenges and communication about school-located influenza vaccination program (SIVP) in Hong Kong. We found that school staff with lower intention to implement SIVP perceived greater logistical difficulties in arranging SIVP. Challenges regarding program delivery included schools’ limited infrastructure, the burden of paperwork, the fear of being overwhelmed by multiple school-based vaccination schedules, lacking confidence in communicating with parents about influenza vaccines, and the difficulties in managing vaccination-related anxiety among children with intellectual disability. School staff were generally passive in communicating with parents and students about influenza vaccines. We also found that schools may use the school newsletters as a substitute of the formal informed consent forms. Good partnerships among government, service providers and schools should be established to minimize the burden of paperwork for school staff, facilitate early planning of SIVP, and support schools with limited infrastructure and the vaccination of children with intellectual disabilities. Training is needed to enhance school staff’s confidence in communicating with parents and students about influenza vaccines and improve information delivery to support parents’ informed decisions for children’s vaccination.
Nocebo-Prone Behavior Associated with SARS-CoV-2 Vaccine Hesitancy in Healthcare Workers
Authors: Mitsikostas Dimos D. , Aravantinou-Fatorou Konstantina , Deligianni Christina , Kravvariti Evrydiki , Korompoki Eleni , Mylona Maria , Vryttia Pinelopi , Papagiannopoulou Georgia , Delicha Eumorphia-Maria , Dellis Athanasios , Tsivgoulis Georgios , Dimopoulos Meletios A. , Amanzio Martina , Sfikakis Petros P.
Published: October 2021

Among healthcare workers (HCWs), SARS-CoV-2 vaccine hesitancy may be linked to a higher susceptibility to nocebo effects, i.e., adverse events (AEs) experienced after medical treatments due to negative expectations. To investigate this hypothesis a cross-sectional survey was performed with a self-completed questionnaire that included a tool (Q-No) for the identification of nocebo-prone individuals. A total of 1309 HCWs (67.2% women; 43.4% physicians; 28.4% nurses; 11.5% administrative staff; 16.6% other personnel) completed the questionnaires, among whom 237 (18.1%) had declined vaccination. Q-No scores were ≥15 in 325 participants (24.8%) suggesting nocebo-prone behavior. In a multivariate logistic regression model with Q-No score, age, gender, and occupation as independent variables, estimated odds ratios (ORs) of vaccination were 0.43 (i.e., less likely, p < 0.001) in participants with Q-No score ≥ 15 vs. Q-No score < 15, 0.58 in females vs. males (p = 0.013), and 4.7 (i.e., more likely) in physicians vs. other HCWs (p < 0.001), independent of age, which was not significantly associated with OR of vaccination. At least one adverse effect (AE) was reported by 67.5% of vaccinees, mostly local pain and flu-like symptoms. In a multivariate logistic regression model, with Q-No score, age, gender, and occupation as independent variables, estimated ORs of AE reporting were 2.0 in females vs. males (p < 0.001) and 1.47 in physicians vs. other HCWs (p = 0.017) independently of age and Q-No score, which were not significantly associated with OR of AE. These findings suggest that nocebo-prone behavior in HCWs is associated with SARS-CoV-2 vaccination hesitancy indicating a potential benefit of a campaign focused on nocebo-prone people.
Stormwater Runoff Modelling in an Urban Catchment to Plan Risk Management for Contaminant Spills for Stormwater Harvesting
Authors: Myers Baden , Awad John , Pezzaniti David , Gonzalez Dennis , Page Declan , Dillon Peter
Published: October 2021

Water quality is a key consideration for urban stormwater harvesting via aquifers. This study assessed catchment spill management options based on a calibrated dynamic wave routing model of stormwater flow in an urban catchment. The study used measured travel times, pluviometer and gauging station observations from 21 storms to calibrate a stormwater model to simulate transport of pollutants from spill locations to the point of harvest. The simulations considered the impact of spill locations, spill durations, storm intensities and storm durations on the pollutant concentration at the point of harvest and travel time of a pollutant spill to the harvesting point. During dry weather, spill events travelled slower than spills occurring during wet weather. For wet weather spills, the shortest travel times tended to occur in higher intensity storms with shorter duration, particularly when a spill occurred in the middle of the storm. Increasing the intensity of rainfall reduced the peak concentration of pollutant at the harvest point via dilution, but it also reduced the time of travel. On a practical level, due to the short response times in urban catchments, management of spills should be supported by automated detection/diversion systems to protect stormwater harvesting schemes.
Characterization of the Transpiration of a Vineyard under Different Irrigation Strategies Using Sap Flow Sensors
Authors: Mancha Luis , Uriarte David , Prieto María
Published: October 2021

Lysimeters are the reference method for determining ETc, but they are expensive and complex, which limits their use. The first objective of this work was to adjust and evaluate the robustness of sap flow sensors in order to determine the transpiration of a vineyard and, together with an evaporation model, to calculate the ETc of the vineyard. For this purpose, we compared water consumption data obtained from a vineyard weighing lysimeter (ETcLys) with the sum of transpiration obtained from sap flow sensors (TSF) and evaporation estimated empirically over four years (2012, 2013, 2014 and 2015). The second objective was to obtain the relationship between the vegetative growth and transpiration of the vines with different water availability (irrigation and rainfed treatments), as an alternative method for estimating vine water needs adjusted to their real development. The third and last objective was to evaluate the transpiration response of the vines when subjected to water stress. We carried out the work in an experimental vineyard which has a well-established weighing lysimeter. As a result, a good match was obtained between vine sap flow and transpiration (R2 = 0.85) as well as a good relationship between vegetative growth and vine transpiration (FiPAR: R2Irrigation = 0.34. R2Rainfed = 0.54; LAI: R2Irrigation = 0.68. R2Rainfed = 0.53).
Multi-Criteria Analysis of the “Lake Baikal—Irkutsk Reservoir” Operating Modes in a Changing Climate: Reliability, Resilience, Vulnerability
Authors: Buber Alexander , Bolgov Mikhail
Published: October 2021

In the second half of the twentieth century, a cascade of reservoirs was constructed along the Angara: Irkutskoe, Bratskoe, Ust-Ilimskoe and Boguchanskoe, which were intended for producing renewable hydroelectric energy for providing transportation through the Angara and Yenisei Rivers, and for avoiding floods. The upper reservoir (Irkutsk Dam) is used to regulate the level of Baikal Lake. The cascade of Angarsk reservoirs is managed using the dispatch schedules developed in 1988. This article contains a multi-criteria analysis of the “Lake Baikal–Irkutsk Reservoir” operating modes in a changing climate, based on statistical summaries of performance criteria: reliability, resilience, vulnerability. Studies have shown that dispatch schedules need to be developed on the historical series of recent years, updated more often and optimization methods should be used for real-time management. This article discusses mathematical methods, algorithms and their implementations for the formation of reservoir operation modes based on dispatch schedules (DS) and optimization methods. Furthermore, mathematical methods, algorithms and programs have been developed for the formation of reservoir operation modes in real time, based on optimization approaches and long-term series of observed inflows, taking into account a given hierarchy of priorities of water users’ requirements. To solve the integer nonlinear large-dimensional task of performing water resource calculations, a special optimization algorithm was developed that allows decomposition of the task into a series of two-year dimensional independent subtasks.
Effects of Chlorpyrifos Ethyl on Cholinesterase and Growth of Silver Barb (Barbonymus gonionotus)
Authors: Cong Nguyen Van , Danh Dinh Thai , Nam Tran Sy
Published: October 2021

Chlorpyrifos ethyl is a popular insecticide widely used in agriculture within the Vietnamese Mekong delta, including for rice farming. Here, local farmers often apply pesticides at very high rates which leads to contamination of the surrounding environment. Silver barb (Barbonymus gonionotus) is a fish species indigenous to the delta, which resides in a variety of water bodies and is also commonly cultivated in rice–fish systems. As a result, this species is at high risk of exposure to chlorpyrifos ethyl. This study aims to determine the lethal concentration (LC50) of chlorpyrifos ethyl, as well as the effects of sub-lethal concentrations on the activity of cholinesterase and growth of Silver barb. Lethal concentration testing was conducted in a static non-renewed system. Three concentrations of chlorpyrifos ethyl (1%, 10% and 20% LC50-96 h) were conducted in triplicate to assess the effects of chlorpyrifos ethyl on the brain cholinesterase (ChE) of fingerling fish for 15 days, and on their growth for 60 days. Results showed that chlorpyrifos ethyl was highly toxic to fingerling Silver barb with a LC50-96 h of 0.119 ppm. The lowest observed effect concentration (LOEC) was 1%LC50-96 h for ChE and 10%LC50-96 h for growth. No observed effect concentration (NOEC) of chlorpyrifos ethyl for growth was 1%LC50-96 h. The result from this study suggests that ChE activity is significantly inhibited at environmentally realistic concentrations in the Vietnamese Mekong delta and can be used as a biomarker of pesticide exposure. Further study in the rice fields as well as in the canals or rivers is required.
Intelligent Virtual Reality Therapy Systems for Motor and Cognitive Rehabilitation: A Survey based on Clinical Trial Studies
Authors: Oliveira Juliana M. de , Munoz Roberto , Duarte João B. F. , Neto Aloísio V. Lira , Menezes José Wally M. , Albuquerque Victor Hugo C.
Published: October 2021

Rehabilitation is the process related to the recovery, maintenance or improvement of physical mental and / or cognitive skills necessary to carry out daily activities. Virtual reality therapy, virtual reality (VR) immersion therapy, simulation therapy or virtual reality exposure therapy is an intervention method of using virtual reality technology for psychological or occupational therapy. The possibility of simulating situations necessary for the treatment, controlling variables and reducing the patient’s exposure to risks are popular factors for this tool. Many studies indicate that therapy with the aid of virtual reality brings great benefits to the patient. In this article, we present, through a review of 117 articles, the feasibility of applying VR in treatments with clinical trial methodology, identifying through the "Patient, Intervention, Comparison and Outcomes" the characteristics, population, treatment time, forms of comparison and if the results obtained are effective. The characteristics identified during the process show that virtual reality applied to therapies can be used without negative interference in the treatment. In addition, the results show that VR in rehabilitation treatments are motivating and show better results than traditional treatments.
Experimental design for verification and validation of harmonic vibration control systems
Authors: Wang J.
Published: October 2021

Verification and validation represent an important procedure for model-based systems engineering design processes. One of the crucial tasks for verification and validation is to test whether the control system has reached performance limit. This is challenging since complicated theories
and complex steps are often involved to achieve such an objective; meanwhile, the state of the art for testing performance limit requires iterative procedures. A simple and one-off experimental design for telling whether a control system reaches its performance limit is thus necessitated.
This article introduces a remarkable test criterion for fulfilling the requirement. Both theoretical foundation and experiment design procedures are presented. Numerical examples are illustrated for the proposed method, where it is also shown that the simple method can be generalized to determining
performance limit maps over both frequencies and physical parameters.
Objetivos de desarrollo sostenible. Relevamiento inicial sobre las acciones y propuestas de contribución de las Facultades de Ciencias Económicas Nacionales Argentinas a la agenda 2030
Authors: Cavallo Marcela Analía , Ledesma Alicia Beatriz , Díaz Liliana Patricia , Facco Silvina María , Benzi Carolina Soledad , Schmidt Strano Erika
Published: October 2021

Este trabajo se realiza en el marco del proyecto de investigación “Aportes de la Universidad a la Agenda 2030. El impacto de las percepciones y expectativas de la comunidad académica de la Facultad de Ciencias Económicas y Estadística (UNR) en la consecución de los Objetivos de Desarrollo Sostenible” y presenta un relevamiento de acciones y propuestas de actividades y espacios en las facultades de ciencias económicas nacionales con relación a la propuesta de la Agenda 2030. En primer lugar, se muestran algunos aportes teóricos que han sido pilares para el diseño metodológico. A continuación, el estudio muestra la sistematización de la información disponible en los sitios web oficiales de las unidades académicas objeto de estudio analizada conforme a categorías teóricas desarrolladas en estudios tomados como referencia, que forman parte del estado del arte en el proyecto de investigación en curso. Como resultado del relevamiento exploratorio de los espacios virtuales de las unidades académicas en ciencias económicas nacionales argentinas, los primeros hallazgos permitieron además la construcción de categorías fundamentadas en esos datos que se incluyeron como subcategorías nuevas en los resultados. Finalmente fue posible arribar a conclusiones en torno a la propuesta teórica de Kestin et al (2017) y a las subcategorías definidas en este estudio, así como el grado de abordaje de las mismas para, finalmente, proponer algunas reflexiones acerca del grado de avance de la temática en Argentina.
Herramientas financieras para Pymes en contextos de incertidumbre. Acercamiento a su aplicación
Authors: Padován Alex A.
Published: October 2021

La economía argentina se caracteriza por sucesivos periodos de inestabilidad marcada en las principales variables macroeconómicas lo que suscita la generación de un contexto volátil donde la incertidumbre enmarca cualquier toma de decisión económica y financiera. Este contexto es particularmente nocivo para los negocios de las empresas pequeñas y medianas, quienes encuentran serios inconvenientes para lograr rentabilidad económica del negocio, generando a posteriori estrangulamientos en el giro financiero, todo lo cual puede afectar la capacidad de la PYME para continuar operativa durante estos ciclos económicos. Este trabajo de investigación tiene como objetivo plantear el abordaje de determinadas herramientas que pueden permitir, en la actualidad morigerar el impacto sobre la rentabilidad financiera del negocio y tener la posibilidad de transitar el ciclo económico adverso con éxito.
Sistema social empresarial y las innovaciones tecnológicas:
Authors: Caila María de las Mercedes , Leda Ayelén Cecilia , Pérez Sebastián , Ulla Irigoyen Verónica Liliana
Published: October 2021

En esta presentación se evalúan las distintas teorías relativas a la innovación empresarial, la innovación social y las teorías de la economía social, señalando los conceptos que se consideran relevantes para el análisis. Asimismo se detallan aspectos significativos del proceso de innovación obtenidos mediante estrategias cualitativas en un estudio de caso.
PENGARUH APLIKASI POC ( PUPUK ORGANIK CAIR ) URIN KAMBING DAN PESTISIDA ALAMI TERHADAP RESPON PERTUMBUHAN TANAMAN KACANG PANJANG ( Vigna sinensis L. ) BEDA VARIETAS DI DESA GUNUNG SELAMAT BILAH HULU LABUHAN BATU
Authors: Pertiwi Sarah Kristi , Rizal Khairul , Triyanto Yudi
Published: October 2021

AbstractThe Effect Of POC (Liquid Organic Fertilizer) Application Of Goat Urine And Natural Pesticides On The Growth Response Of Long Bean (Vigna Sinensis L.) Plant In Mountain Village Bilah Hulu Labuhan Batu, Sarah Kristi Pertiwi1, Khairul Rizal S.TP, M.Si2, Yudi Triyanto SP, M.Si3 Program Studi Agroteknologi, Fakultas Sains dan Teknologi Universitas Labuhanbatu. Long beans (Vigna sinensis L.)  are a vegetable plant as a source of vitamins and minerals. Long beans (Vigna sinensis L.)  are also a type of legume that is widely cultivated in Indonesia. Gunung Selamat Village is one of the villages with a variety of agricultural crops, one of which is long beans (Vigna sinensis L.). However, this community service was carried out because of the many problems faced by farmers, which caused the growth of long beans (Vigna sinensis L.)  to decline. The decline in production was caused, among others, by climate, soil, fertilizers, pests and diseases. Therefore, this community service is carried out to increase plant growth and reduce the use of synthetic fertilizers that can damage the soil ecosystem, therefore it is given the treatment of sprinkling liquid organic fertilizers on the soil and spraying vegetable pesticides from papaya leaves to prevent pests and diseases that attack long bean plants (Vigna sinensis L.). This treatment was designed to see the results of the growth rate response in long bean plants (Vigna sinensis L.). Keywords: Long Beans (Vigna sinensis L.), Liquid Organic Fertilizer, Natural Pesticides, Long Bean (Vigna sinensis L.) Plant Growth Response. AbstrakKacang Panjang (Vigna sinensis L.) merupakan salah satu tanaman sayuran sebagai sumber vitamin dan mineral. Kacang panjang (Vigna sinensis L.)  juga merupakan jenis kacang-kacangan yang banyak diusahakan di Indonesia. Desa Gunung Selamat merupakan salah satu desa dengan penghasilan tanaman palawija yang beragam salah satunya kacang panjang (Vigna sinensis L.). Namun, pengabdian masyarakat ini dilakukan karena banyak permasalahan yang dihadapi oleh petani sehingga menyebabkan pertumbuhan kacang panjang (Vigna sinensis L.)  menurun. Turunnya produksi ini antara lain disebabkan oleh iklim, tanah, pupuk, hama dan penyakit. Maka dari itu pengabdian masyarakat ini dilakukan untuk meningkatkan pertumbuhan tanaman serta mengurangi penggunaan pupuk sintetik yang dapat merusak ekosistem tanah, maka dari itu diberi perlakuan penyiraman pupuk organik cair pada tanah serta penyemprotan pestisida nabati dari daun pepaya untuk mencegah hama dan penyakit yang menyerang tanaman kacang panjang (Vigna sinensis L.). Perlakuan ini dibuat untuk melihat hasil respon tingkat pertumbuhan pada tanaman kacang panjang (Vigna sinensis L.).
EFEKTIVITAS E-MODUL ANALISIS REAL PADA PROGRAM STUDI PENDIDIKAN MATEMATIKA UNIVERSITAS KANJURUHAN MALANG
Authors: Riyadi Selamet , Qamar Kawakibul
Published: October 2021

Fokus penelitian ini adalah mengoptimalkan peran bahan ajar dengan mengembangkan dalam bentuk e-modul pada Program Studi Pendidikan Matematika Universitas Kanjuruhan Malang. Secara harfiah, e-modul dapat dimaknai sebagai modul elektronik, non cetak dan hanya berupa file yang dapat dibuka dengan bantuan media elektronik seperti Tablet, Smartphone, komputer PC dan media elektronik lain berbasis sistem operasi terutama Android. Salah satu perkuliahan yang mempunyai keterbatasan handout serta mempengaruhi kompetensi mahasiswa adalah mata kuliah Analisis Real. Model pengembangan yang digunakan dalam pengembangan modul pembelajaran ini adalah model pengembangan yang dirumuskan oleh Thiagarajan dengan model 4-D yang langkah-langkahnya meliputi Define, Design, Develop, Disseminate. Hasil kuisioner menunjukkan persentase modul pembelajaran. sebesar 82,05% yang mengindikasikan bahwa e-modul berada dalam kualifikasi baik.The focus of this study is to optimize the role by developing teaching materials in the form of e-modules in Mathematics Education Kanjuruhan University of Malang. Literally, e-modules can be interpreted as an electronic module, non-print and only in the form of files that can be opened with the help of electronic media such as tablets, smartphones, PCs and other electronic media, especially Android-based operating system. One of the lectures that have limited handouts and influencing students' competencies are courses Real Analysis. Model development used in the development of this learning module is a development model formulated by Thiagarajan with 4-D model of the steps include Define, Design, Develop, Disseminate. Results of questionnaires show the percentage of learning modules. of 82.05%, which indicates that the e-modules are in a good qualification
Profil Pemahaman Mahasiswa dalam Memecahkan Masalah pada Matakuliah Matematika SMP Ditinjau dari Multiple Intelligence
Authors: Susanti Vera Dewi
Published: October 2021

Tujuan penelitian ini adalah untuk mengetahui profil pemahaman mahasiswa semester III dengan kecerdasan linguistik, matematis logis dan visual dalam memecahkan masalah Matematika SMP. Metode penelitian yang digunakan adalah pendekatan kualitatif. Subyek penelitian terdiri dari tiga mahasiswa yang masing-masing memiliki jenis inteligensi linguistik, matematis logis, dan visual yang dominan. Teknik pengumpulan data berdasarkan hasil tes dan wawancara. Teknik analisis data terdiri dari reduksi data, penyajian data dan penarikan kesimpulan. Teknik keabsahan data yang digunakan adalah triagulasi teknik. Hasil penelitian ini adalah (1) Mahasiswa linguistik memenuhi 3 indikator pemahaman yaitu menerjemahkan, menafsirkan dan mengekstrapolasi dengan menerapkan pemecahan masalah secara berurutan dimulai dari memahami masalah, merencanakan pemecahan masalah, melaksanakan rencana dan memeriksa kembali, namun cenderung dalam memahami masalah. (2) Mahasiswa matematis logis memenuhi 3 indikator pemahaman yaitu menerjemahkan, menafsirkan dan mengekstrapolasi dengan menerapkan pemecahan masalah secara berurutan dimulai dari memahami masalah, merencanakan pemecahan masalah, melaksanakan rencana dan memeriksa kembali, namun cenderung dalam merencanakan pemecahan masalah. (3) Mahasiswa visual memenuhi 3 indikator pemahaman yaitu menerjemahkan, menafsirkan dan mengekstrapolasi dengan menerapkan konsep pemecahan masalah secara berurutan dimulai dari memahami masalah, merencanakan pemecahan masalah, melaksanakan rencana dan memeriksa kembali, namun cenderung pada memahami masalah dengan menggunakan sketsa atau gambar.
Merancang Uji Coba Realistic Mathematics Education (RME)
Authors: Nuraida Ida
Published: October 2021

Tujuan perancangan uji coba RME adalah untuk mengetahui apa yang harus dipersiapkan dalam  menghadapi perancangan uji coba matematika realistik, untuk mengetahui apa yang dilakukan dalam perancangan uji coba di sekolah, untuk mengetahui produk apa yang dihasilkan setelah  perancangan uji coba matematika realistik, dan untuk mengetahui tindak lanjut yang harus dilakukan apabila perancangan yang harus dilakukan tidak sesuai dengan harapan matematika realistik. Uji coba pembelajaran matematika di suatu sekolah dengan menggunakan pendekatan realistik memerlukan perencanaan yang matang, karena pembelajaran menggunanakan pendekatan realistik sangat kompleks, yaitu dimulai dari persiapan guru, persiapan fasilitas, persiapan materi, bahan ajar sampai kesiapan semua komponen yang ada di sekolah tersebut. Berdasar hal tersebut maka dalam uji coba RME memerlukan rancangan. Produk yang dihasilkan dari perancangan matematika realistik adalah pengetahuan guru, buku guru, buku siswa, silabus, RPP, LAS, dan instrumen.
Desain Didaktis Konsep Luas Daerah Trapesium Pada Pembelajaran Matematika Sekolah Menengah Pertama
Authors: Mulyani Eva
Published: October 2021

Penelitian ini dilatarbelakangi oleh munculnya hambatan belajar (learning obstacle) yang dialami peserta didik tentang konsep luas daerah trapesium. Tujuan penelitian ini adalah untuk menyusun dan mengimplementasikan bahan ajar pada konsep luas daerah trapesium. Lokasi penelitian dilaksanakan di SMP Negeri 2 Tasikmalaya. Penelitian ini menggunakan metode penelitian Desain Didaktis (Didactical Design Research). Teknik pengumpulan data dalam penelitian ini dilakukan dengan melaksanakan uji instrument learning obstacle, implementasi desain didaktis, wawancara dan dokumentasi. Hasil penelitian ini adalah suatu desain didaktis alternatif yang dapat digunakan dalam pembelajaran matematika Sekolah Menengah Pertama (SMP) pada materi konsep luas daerah trapesium.
Pengaruh Penggunaan Model Project Based Learning Terhadap Kemampuan Pemecahan Masalah Matematik Peserta Didik SMA
Authors: Muslim Siska Ryane
Published: October 2021

Penelitian ini bertujuan  untuk mengetahui pengaruh positif  penggunaan model Project Based Learning terhadap kemampuan pemecahan masalah matematik peserta didik dan untuk mengetahui bagaimana kemandirian belajar peserta didik dalam pembelajaran matematika dengan menggunakan  model Project Based Learning. Metode penelitian yang digunakan adalah metode penelitian eksperimen. Populasi dalam penelitian ini yaitu peserta didik kelas X SMA Negeri 3 Tasikmalaya. Sampel diambil secara acak menurut kelas, kelas yang menjadi sampel yaitu kelas X-1 sebagai kelas eksperimen yang berjumlah 33 orang peserta didik dan kelas X-3 sebagai kelas kontrol yang berjumlah 34 orang peserta didik. Instrumen yang digunakan berupa soal tes kemampuan Pemecahan Masalah matematik peserta didik dan lembar observasi kemandirian belajar peserta didik. Berdasarkan hasil penelitian analisis data, dan uji hipotesis dapat disimpulkan bahwa terdapat pengaruh positif penggunaan model Project Based Learning terhadap kemampuan Pemecahan Masalah eatif matematik peserta didik dan kemandirian belajar peserta didik dalam pembelajaran matematika dengan menggunakan  model Project Based Learning memperoleh kategori tinggi.
Pengembangan Soal Matematika Open-Ended Berkonteks Bumi Rafflesia
Authors: Ramadianti Winda , Syofiana Mardiah , Mahyudi Mahyudi
Published: October 2021

Tujuan dari penelitian ini adalah untuk menghasilkan soal  matematika open ended dalam konteks Bumi Rafflesia yang valid, praktis, dan memiliki efek potensial untuk mengembangkan kemampuan berpikir kreatif matematis siswa SMP. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian pengembangan yang terdiri dari tiga tahapan yaitu preliminary, prototyping, assessment. Analisis data yang digunakan adalah analisis kualitatif. Hasil penelitian berupa soal-soal open-eden berkonteks bumi Rafflesia yang terdiri dari 15 soal dalam bentuk uraian yang telah valid, praktis, dan memiliki efek potensial untuk mengembagkan kemampuan berpikir kreatif matematis.
Pengintegrasian TPACK dalam Pembelajaran Transformasi Geometri SMA untuk Mengembangkan Profesionalitas Guru Matematika
Authors: Rafi Ibnu , Sabrina Nurrita
Published: October 2021

Artikel ini membahas mengenai cara pengintegrasian kerangka Technological,  Pedagogical and Content Knowledge (TPACK) dalam pembelajaran transformasi geometri SMA untuk mengembangkan profesionalitas guru matematika. Artikel ini merupakan hasil kajian pustaka dengan sumber kajian berupa artikel jurnal, undang-undang dan laman web yang bertemakan TPACK, Uji Kompetensi Guru (UKG), profesionalitas guru, dan penggunaan GeoGebra dalam pembelajaran. Penulisan artikel ini dilatarbelakangi oleh capaian rata-rata Uji Kompetensi Guru (UKG) pada bidang studi matematika yang mengindikasikan perlu adanya pengembangan profesionalitas guru matematika, terutama pada kompetensi pedagogik dan profesional. Salah satu kerangka yang memfasilitasi pengembangan dua kompetensi tersebut adalah Technological, Pedagogical and Content Knowledge (TPACK). Melalui TPACK, guru matematika diharapkan dapat mengintegrasikan teknologi dalam pembelajaran pada materi matematika yang bersifat abstrak, seperti transformasi geometri. Berdasarkan hasil kajian, pengintegrasian TPACK dapat mengembangkan profesionalitas guru matematika melalui kegiatan workshop penggunaan GeoGebra dalam pembelajaran transformasi geometri SMA. DOI: https://doi.org/10.31235/osf.io/v2ygb
Penerapan Bahan Ajar Trigamaster Untuk Menghindari Mind In Chaos Siswa Pada Pokok Bahasan Trigonometri
Authors: Sartika Nenden Suciyati
Published: October 2021

Peneliti menerapkan materi Trigonometri yang dikembangkan melalui bahan ajar Trigamaster. Penerapan bahan ajar Trigamaster pada trigonometri dimaksudkan untuk menghindari terjadinya mind in chaos siswa dalam pembelajaran matematika. Mind in chaos pada siswa terhadap pelajaran matematika merupakan suatu kesan negatif yang jika dibiarkan terjadi sejak mereka masih kecil, yang pada akhirnya hingga dewasa kesan negatif tersebut, yang menyatakan bahwa matematika itu sulit dan menakutkan tetap menetap pada siswa. Hasil penelitian adalah penerapan bahan ajar Trigamaster untuk menghindari Mind In Chaos siswa sehingga memberikan pengalaman dan kesan positif siswa terhadap matematika khususnya pada pokok bahasan Trigonometri pembelajaran matematika.
Pengembangan Media Visual Basic Application untuk Meningkatkan Kemampuan Penalaran Siswa SMP dengan Pendekatan Open-Ended
Authors: Rohaeti Euis Eti , Bernard Martin , Novtiar Chandra
Published: October 2021

Penelitian ini memiliki tujuan mengetahui pengaruh media pembelajaran Visual Basic Application (VBA) for Microsoft Powerpoint dan Excel pada materi peluang terhadap kemampuan penalaran matematis siswa SMP. Sampel pada penelitian ini adalah 23 siswa kelas VIII salah satu SMP di Kota Cimahi Tahun Pelajaran 2018/2019. Pengambilan data diperoleh dengan metode tes untuk menentukan kemampuan penalaran matematis siswa yang kemudian dianalisis ketercapaian dan kesulitan siswa pada setiap indikator yang menjadi dasar pengembangan media pembelajaran. Media kemudian diujicobakan kembali dalam pembelajaran. Hasil dari penelitian ini adalah adanya pengaruh media pembelajaran Visual Basic Application (VBA) for Microsoft Powerpoint dan Excel dalam meningkatkan kemampuan penalaran siswa pada materi peluang, dan media tersebut dapat membantu guru saat menggunakan pendekatan Open-Ended sehingga pembelajaran di kelas lebih efektif, serta menciptakan pembelajaran peluang menjadi interaktif dan menyenangkan.
Distinguishing capture cross-section parameter between GIDL erase compact model and TCAD
Authors: Lee Kul , Shin Hyungcheol
Published: October 2021

A compact model of 3D NAND enables simulation at circuit- or system-level. Although a compact model for gate-induced-drain-leakage (GIDL)-assisted erase was proposed in a previous study, it is difficult to use practically because it has not been properly validated. In particular, a capture cross-section (CCS) value that is far from the real value is used. Furthermore, it does not consider the latest device structure and its operation. In this paper, a conventional GIDL-assisted erase compact model is validated using TCAD and has been improved more practically. It is confirmed that we should distinguish between CCS in TCAD and the compact model due to their differences. Based on their physical differences, an equation that can interconvert them is proposed and the model is successfully validated with proper CCS. Finally, the advanced GIDL-assisted erase compact model considering a tapered angle, single-side injection and word-line voltage is suggested.
Un vaccino contro o relativo all’influenza?
Authors: Di Carlo Miriam
Published: October 2021

Rispondiamo ai molti quesiti rivolti all’Accademia sulla correttezza di vaccino influenzale in alternativa a vaccino antinfluenzale. In alcune delle segnalazioni si parla di cartelli esposti nelle farmacie o nei consultori in cui compare vaccino influenzale anziché vaccino antinfluenzale.
Application of the Question and Answer Learning Method Through Reasoning Techniques to Improve Learning Activities of Class 6 Students at SDN Sukaharja 1 Telukjambe Timur District, Karawang Regency
Authors: Yayat Suryati  , Tarpan Suparman
Published: October 2021

The purpose of this study was to determine the increase in student learning activities by using the question and answer method through talaran techniques carried out on grade 6 students of Sukaharja 1 Elementary School, Telukjambe Timur District, Karawang Regency. The research method used is classroom action with observational research techniques, interviews, and tests and documentation. The researcher evaluates the learning process according to the success indicators that have been determined according to the competency standards and basic competencies and compares them with the Minimum Completeness Criteria (KKM), which is 65. The results of the analysis in the first cycle at the fourth meeting show that the value of students is still below the KKM as many as three participants students, with the lowest score of 51, and the class average was 86.16. In the second cycle, it shows an increase in the value of students at the fourth meeting with the lowest score of 70, and none of the students get a score below the KKM. The class average score has increased to 88.25. The learning activities of students had increased, which occurred in the first cycle obtaining an average of 58.10% to 76.51%. Meanwhile, the interviews conducted in the first cycle compared to the second cycle have different activities. In the first cycle, students still acted indifferently when the teacher explained and asked questions. In the second cycle, all students can respond well. The results showed that the application of the learning method through the memorization technique could increase the activity of grade 6 students in participating in learning at the Sukaharja 1 Elementary School, Telukjambe Timur District, Karawang Regency.
An Existence Result for a Class of Coupled Polyharmonic Systems
Authors: Ben Yahia Zeineb , Zine El Abidine Zagharide
Published: October 2021

This work deals with the existence of positive continuous solutions for a nonlinear coupled polyharmonic system. Our analysis is based on some potential theory tools, properties of functions in the Kato class Km, n and the Schauder fixed point theorem.
Cretaceous stage boundaries in the southern Interior Plains of Canada
Authors: Caldwell W. G. E. , North B. R.
Published: October 2021

Marine Cretaceous rocks of Berriasian to Aptian age are restricted to northwestern Alberta and north­eastern British Columbia where many stage and substage boundaries may be drawn only tentatively on the basis of limited molluscan faunas. A complete marine Albian succession is similarly restricted, although the middle and upper divisions of the stage are much more widespread. The complete Albian succession of the Peace River district contains a refined and well-documented sequence of ammonite and foraminiferal zones and would be a most suitable continental standard.
The Albian-Cenomanian (Lower-Upper Cretaceous) boundary has been reliably established in the continuous foraminifer- and mollusc-bearing sequences of the northwestern plains, but eastward it becomes enclosed in a hiatus. The same is true of successive stage boundaries from the Cenomanian­Turonian to the Santonian-Campanian. The bases for establishment of these boundaries, therefore, can be fully considered only on the western flank of the basin. The Campanian-Maastrichtian boundary may be precisely drawn in western Saskatchewan and traced westward to the Rocky Mountain front.
Zones based on ammonites and inoceramid bivalves form· the cornerstone of the biostratigraphy and chronostratigraphy of the southern Interior Plains and hold the key to the stage boundaries. Zones based on assemblages of benthonic foraminifers, rarely of planktonic foraminifers, supplement the molluscan zones. The foraminiferal zones are less reliable and less useful, however, because some benthonic assemblages are weakly diachronous, most foraminiferal zones span several molluscan zones, and many stage boundaries fall within individual foraminifer zones.
Tentative world-wide correlation of Early Cretaceous strata by limestone-marl cyclicities in pelagic deposits
Authors: Cotillon Pierre
Published: October 2021

Bed-scale pelagic marl-limestone alternations at a number of localities in the Tethyan realm are cyclic and display common characters related to duration, composition, mineralogical and microfaunal content. Parameters used to characterize the cycles show parallel evolutions in time over large areas and thus allow accurate correlation. Cycle thickness variations, figured by "cyclograms", makes it possible to correlate sequences from southeastem France to the northeastem Gulf of Mexico and also to apply the biozonation of Angles' parastratotype, located in the Vocontian Trough, to the oceanic Valanginian sections. Variation curves of minor cycle frequency also expresse the accumulation rate which is mainly influenced by the production of planktonic carbonate. They allow North Atlantic and worldwide correlations, particularly for Hauterivian and Albian sections. Whatever the global cause was controlling the variation of planktonic productivity (either very long-term climatic fluctuations or eustatic changes), the curves, which reflect these variations, present an efficient stratigraphic tool for transoceanic correlations especially when biostratigraphic methods are ineffective. Furthermore, they reflect some major Lower Cretaceous boun­daries of the western Tethys.
The Cenomanian-Turonian boundary problem in NW-Germany with comments on the north-south correlation to the Regensburg Area
Authors: Ernst G. , Wood C. J.
Published: October 2021

The lithostratigraphical successions across the Cenomanian-Turonian boundary are described. Two dif­ferent facies can be distinguished: A shallow water red marly limestone facies ('Rotpliiner') characterised by evidence of condensation and stratigraphical hiati; and a more complete deeper water facies with alternating marly limestones and black shales ('Black Shales' or 'SchwarzweiBe Wechselfolge'). A se­quence of litho- and ecoevents permits subdivision and correlation of the two facies. The base of both facies is apparently isochronous and rests on white coccolith limestones, the so-called 'Arme rhotoma­gense Schichten' of the Upper Cenomanian Calycoceras naviculare Zone. The stage boundary was traditionally drawn at the facies change, but biostratigraphical evidence places the boundary within the Rotpliiner/Black Shale formations.
In Lower Saxony the extinction datum of Rotalipora cushmani agrees with records from other areas, i.e. within the Upper Cenomanian Metoicoceras ges/inianum Zone below the entry of Actinocamax
plenus. From the Teutoburger Wald (Miinsterland) and Regensburg area (Bavaria) an apparent di­achroneity of this datum is indicated. The uppermost Cenomanian Neocardioceras juddii Zone of the international scheme has been identified only in the Black Shale facies. The diagnostic ammonites and inocaramid (Mytiloides aff. duplicostatus) of the basal Turonian Pseudaspidoceras f/exuosum Zone have not been recorded in either facies. For practical purposes the base of the Turonian is taken at the entry of Myti/oides, as is usual in Central Erope. Below this level there is a 'zone of uncertainty' with poorly preserved inoceramids of questionable generic identity. Above the entry of recognizable Mytiloides, an interregional fades-independent Myti/oides mytiloides ecoevent is traceable across W.-Germany to east­ern England.
Critical species concepts within Mytiloides are reviewed in the context of possible facies dependence. Of importance for the North-South correlation is the recognition of Mytiloides sp. at the base of the Praeglobotruncana helvetica Zone in the Regensburg area.
α-Ketol and α-iminol rearrangements in synthetic organic and biosynthetic reactions
Authors: Benz Scott , Murkin Andrew S
Published: October 2021

In the presence of a suitable acid or base, α-hydroxyaldehydes, ketones, and imines can undergo isomerization that features the 1,2-shift of an alkyl or aryl group. In the process, the hydroxy group is converted to a carbonyl and the aldehyde/ketone or imine is converted to an alcohol or amine. Such α-ketol/α-iminol rearrangements are used in a wide variety of synthetic applications including asymmetric synthesis, tandem reactions, and the total synthesis and biosynthesis of natural products. This review explores the use of α-ketol rearrangements in these contexts over the past two decades.
Insight into the Role of IL-1β rs1143634 (+3954C>T) Polymorphism in Cancer Risk: An Updated Meta-analysis and Trial Sequential Analysis
Authors:   Noakhali Science and Technology University, Jafrin Sarah , Aziz Md. Abdul , Islam Mohammad Safiqul
Published: October 2021

Review question / Objective: To assess the link of IL-1β rs1143634 (+3954C>T) Polymorphism with cancer. Condition being studied: The included studies must contain 1) genotypic information and detailed data of IL-1β rs1143634 (+3954C>T) polymorphism 2) case-control studies. Information sources: PubMed, Google Scholar, CNKI, Web of Science, and EMBASE.