bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS BEBAN KERJA MENTAL DAN FISIK MENGGUNAKAN METODE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION TASK LOAD INDEX (NASA-TLX) DAN CARDIOVASCULAR (CVL) (STUDI KASUS : CV. GRIYA SERASI PRODUKUTAMA)
Authors: Prasandi Farhan Naufal , Marlyana Novi , Sukendar Irwan
Published: July 2023

CV. Griya Serasi Produkutama merupakan perusahaan dibidang advertising. Perusahaan ini memiliki 9 karyawan, dibagian indoor dan outdoor, pada proses produksinya karyawan dituntut melakukan semua proses produksi secara bersamaan dan tidak terpaku pada satu proses produksi saja. Kondisi ini menyebabkan karyawan mengalami beban mental dan fisik berlebih karena melebihi jam kerja normal. Selain itu karyawan mengalami tekanan sampai kewalahan jika terjadi lonjakan pesanan secara tiba-tiba dikarenakan adanya event tertentu yang bersamaan dengan adanya proses produksi lainnya. Hal itu akan menimbulkan kelelahan berlebih dan akan mengganggu kesehatan. Beban kerja yang diukur adalah beban kerja mental dan fisik untuk mengetahui beban mental pada karyawan diukur dengan metode NASA-TLX dan beban kerja fisik diukur menggunakan metode CVL. Berdasarkan masalah tersebut analisa metode NASA-TLX memiliki rata-rata beban kerja mental 69,68% kategori sedang. Terdapat satu karyawan mempunyai WWL berat > 80 % yaitu Mamat 83,13%. Hasil analisa CVL diperoleh rata-rata 19,87% kategori tidak terjadi kelelahan. Dan dua karyawan diperlukan perbaikan yaitu Aris 36,48% CVL dan Budi 32,10% CVL. Berdasarkan analisa peneliti mengusulkan makanan nutrisi, peningkatan semangat kerja memberikan pelatihan, pemberian reward tiap bulannya. meningkatkan skill, memperhatikan kesehatan dengan memberikan check-up minimal satu kali dalam setahun.
STEM 4.0 APPROACH TO STRENGTHEN ADAPTIVE STUDENT CHARACTER
Authors: Sukamto Ismu , Maulina Hervin , Pangestu Deviyanti , Ghufron Anik
Published: July 2023

The purpose of this study was to determine the effectiveness of the STEM 4.0 approach in increasing CT which included differences in CT in experimental and control class students and in increasing student CT.The research method used is Quasi-Experimental Design with One Group Pretest-Postest. This research involved 56 university students. The sample was treated in the form of learning with the STEM approach. Student CT includes 5 indicators, namely: (1) Interpreting Problems, (2) Analyzing Solution of the Problem, (3) Applying Gained Solution, (4) Evaluating the Gained Solution, and (5) Concluding the Results Attached with Supportive Evidence.The results of the study prove that based on the results of the Independent T-Test, there are significant differences in students' CT in the STEM class and the conventional class. The increase in CT in the experimental group was also significant based on the results of the Paired Samples Test. Thus, it can be concluded that the STEM 4.0 approach facilitates students to master the concepts of learning materials (Science) with the help of technology (Technology) and is strengthened by the application of these concepts in making simple products (Engineering). In addition, concept mastery is also supported by linking environmental phenomena in learning (Mathematics). The implementation of STEM 4.0 is effective in improving CT.
Pengembangan Program Pengenalan Marketplace Digital Jiwa Wirausaha Pada Siswa Tunagrahita
Authors: Ashari Varricha Vina , Ediyanto Ediyanto , Pramono Eka
Published: July 2023

Vocational programs have become a trend in many countries around the world. In America, business schools are often out of reach of the lower middle class, especially in rural areas and small towns. Idayu 2 Pakis Malang Vocational Program, the vocational program has not found additional solutions in terms of operational performance. Therefore, it is necessary to encourage digital entrepreneurship that remains current. In addition, children's independence is highly expected and creates jobs, especially for Intellectual Disability children. Children with Intellectual Disability have a level of intelligence that is far below average which is characterized by limited intelligence and inability to interact socially. The condition of Intellectual Disability children who have below average levels of intelligence makes it difficult to think logically, making them less able to find and realize their desires. This study aims to increase the entrepreneurial spirit of students with disabilities, especially those who were most often the subject of previous research, namely students with limited intelligence and inability to interact socially or often called Intellectual Disability. This research was conducted using a continuous development research method. This continuous development research method is a method used to develop certain products and test the effectiveness of these products, the authors conclude that to achieve success in increasing the entrepreneurial spirit, learning practices must be packaged in interesting learning for children with special needs, especially Intellectual Disability students. By providing media or teaching materials that attract Intellectual Disability students, they will more quickly absorb learning and entrepreneurial spirit related to learning.
PERBANDINGAN KEJADIAN ANEMIA PADA IBU HAMIL YANG TERPAPAR DAN TIDAK TERPAPAR ASAP ROKOK DI DESA TAENG KABUPATEN GOWA
Authors: Rosdianah  , Anna Khuzaimah  , Yusril Ihsanul Mukarram  , Aura Audhilla Khadiamsi
Published: July 2023

Anemia merupakan kondisi kadar hemoglobin ibu berada di bawah normal sesuai dengan usia kehamilan. Salah satu faktor resiko terjadinya anemia adalah paparan asap rokok sebelum dan selama hamil dikarenakan pada asap rokok mengandung banyak zat yang berbahaya. Penelitian ini bertujuan untuk melihat perbandingan kejadian anemia pada ibu hamil yang terpapar dan tidak terpapar asap rokok. Jenis penelitian yang digunakan adalah cross sectional dengan metode pengambilan sampel yang digunakan adalah consecutive sampling dan didapatkan sampel sebanyak 57 sampel. Hasil penelitian didapatkan sebanyak 29 sampel (50,9%) terpapar asap rokok dan mengalami anemia, sedangkan sebanyak 7 sampel (12,3%) terpapar asap rokok tapi tidak mengalami anemia. Untuk sampel yang tidak terpapar asap rokok namun mengalami anemia sebanyak 3 sampel (5,2%) dan sebanyak 18 sampel (31,6%) tidak terpapar asap rokok dan juga tidak mengalami anemia. Kesimpulan dari hasil penelitian ini adalah angka kejadian anemia akan lebih tinggi pada ibu hamil yang terpapar asap rokok dibandingkan dengan yang tidak terpapar asap rokok.
EFEKTIVITAS EKSTRAK DAUN SIRSAK (Annona muricate Linn) TERHADAP PERUBAHAN KADAR FRAKSI LIPID PADA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG MENGALAMI DISLIPIDEMIA
Authors: Hidayati Prema Hapsari , Gina Isni Djanuaresty Iskandar  , Mufia Muin  , Nurul Faiqah  , Agung Sukriadi  , Rahmawati Mamille
Published: July 2023

Latar Belakang: Dislipidemia berhubungan dengan angka mortalitas akibat penyakit kardiovaskuler. Daun sirsak adalah obat tradisional yang dapat menurunkan kadar kolesterol darah. Studi mengenai efektivitas daun sirsak terhadap kadar kolesterol masih kurang dan mendapatkan hasil bervariasi. Tujuan: Mengetahui efek ekstrak daun sirsak (Annona muricata Linn) terhadap perubahan kadar fraksi lipid pada.Tikus jantan putih yang mengalami dislipidemia. Metode: Penelitian ini menggunakan one group pre-test post-test pada 15 ekor tikus putih jantan yang dibagi menjadi 3 kelompok. Kelompok pertama diberi ekstrak daun sirsak, kelompok kedua diberi simvastatin dan kelompok ketiga  diberi placebo. Hasil: Pada awal penelitian, pada kelompok tikus yang mendapat ekstrak Annona muricata,  rerata kadar kolesterol total adalah 188,4 mg/dL, trigliserida 107,4 mg/dl, LDL 94 mg/dl, dan HDL 24,8 mg/dl. Setelah perlakuan  didapatkan  rata rata kadar kolesterol total 136,2 mg/dL (p=0.023), trigliserida 90,4 mg/dL (p=0.018), LDL 81 mg/dL (p=0.000), HDL 28.8 mg/dL (p=0.02).  Kesimpulan: Ekstrak daun Annona muricata L dapat menurunkan secara signifikan kadar kolesterol total, kolesterol LDL, dan trigliserida,  serta juga dapat meningkatkan  kadar kolesterol HDL pada kelompok tikus hiperkolesteromia yang diinduksi oleh diet.
The Adaptation of the State Self-Compassion Scale Long and Short Form to Turkish Culture: Validity and Reliability Study
Authors: Ümmet Durmuş , Ünal Halil , Eksi Halil
Published: July 2023

Study 1. This study aimed to examine the psychometric properties of the Turkish version of the State Self-Compassion Scale-Long Form (SSCS-L). The research was conducted on 536 individuals. As a result of the linguistic equivalence study, a positive significant correlation ranging from r=.384 to .909 was found between the original and Turkish items of the study. As a result of CFA, fit index values were found as (χ2/sd= 386.886/120=3.224, p=.00), RMSEA=.064, NFI=.915, CFI=.939, IFI=.940, RFI=.892, GFI=.923 and SRMR=.046. The Self-Compassion Scale was used to test the criterion-related validity. Spearman's rank correlation coefficient was found to be .841. The internal consistency coefficient of the factors of the scale was calculated between .742 and .923. The item-total correlations ranged from .39 to .80, while the item discrimination index values of the upper-lower group ranged between 8.22 and 22.3. The research findings demonstrated that the State Self-Compassion Scale-Long Form is a valid and reliable instrument in Turkish culture.Study 2. This study aimed to examine the psychometric properties of the Turkish version of the State Self-Compassion Scale-Short Form (SSCS-S). The research was conducted on 536 individuals. As a result of the linguistic equivalence study, a positive significant correlation ranging from r=.505 to .797 was found between the original and Turkish items of the study. As a result of CFA, fit index values were found as (χ2/sd= 31.660 /9=3.518, p=.00), RMSEA=.075, NFI=.954, CFI=.967, IFI=.967, RFI=.924, GFI=.979 and SRMR=.033. The Self-Compassion Scale was used to test the criterion-related validity. Spearman's rank correlation coefficient was found to be .873. Cronbach's alpha coefficient was calculated .782 for the scale. The item-total correlations ranged from .36 to .64, while the item discrimination index values (t) of the upper-lower group ranged between 12.69 and 21.65. The research findings demonstrated the State Self-Compassion Scale-Short Form is a valid and reliable instrument in Turkish culture.
Digital Technology in Preschool Education: A Systematic Review
Authors: Atış Akyol Nevra , Turanoğlu Rabia , Parpucu Nurbanu
Published: July 2023

Studies on digital technology have become increasingly important for restructuring education both in the world and in Turkey. The rapid increase studies concerning digital technology in the field of preschool education in recent years reveal the need for a systematic review study that will guide future studies by evaluating the current situation of digital technology studies in Turkey. Within the scope of the research, the studies to be included in the systematic review were examined with the determined keywords between 2017-2022 and determined by examining based on the inclusion-exclusion criteria. 136 studies were included in the research and examined based on publication dates, research method, participant type, analysis method used and the subject of the study. The data were analysed by content analysis. The results showed that studies on digital technology in the preschool period have increased in recent years, content analysis is used more in parallel with the qualitative research method, documents are frequently reviewed, and that the most frequently discussed subject is the use of technology in education.
Notes on the New World allopatric beetle genus Mycotrupes (Scarabaeoidea: Geotrupidae) and on Geotrupacarus mycotrupetes (Krantz and Mellott) (Acari: Macrochelidae), an early derivative phoretic mite associate of Mycotrupes gaigei Olson and Hubbell in southeastern United States
Authors: Krantz Gerald W.
Published: July 2023

The five described species of the flightless, allopatric geotrupid beetle genus Mycotrupes are restricted to deep sand ridges in peninsular Florida and to adjacent, elevated sand hill habitats along the juncture of the Piedmont and the Atlantic Coastal Plain in southern South Carolina and Georgia, USA. Based on examination of major museum collections of all five described Mycotrupes species, it was concluded that Geotrupacarus mycotrupetes, a distinctive, early derivative macrochelid mite phoretic on Mycotrupes gaigei, does not occur on any of the other four described species of Mycotrupes, nor have other species of Geotrupacarus been found on any of these beetles, all of which (like Myco. gaigei) are isolated and allopatric in their own sand ridge or sand hill habitats. It also was determined that Geotrupes egeriei Germar, a winged, widely distributed geotrupid beetle that co-occurs with Myco. gaigei in Florida and which is strongly attractive to G. mycotrupetes in laboratory settings, has not expanded the range of G. mycotrupetes beyond peninsular Florida.
Stroke risk in radial versus femoral approach in coronary intervention: an updated systematic review and meta-analysis
Authors: Desai Aditya M. , Desai Darshi , Gan Arnold , Mehta Devanshi , Ding Kimberly , Gan Frances , Riangwiwat Tanawan , Sethi Prabhdeep S. , Mukherjee Ashis , Pai Ramdas G. , Prasitlumkum Narut
Published: July 2023

Aim

Peri-cardiac catheterization (CC) stroke is associated with increased morbidity and mortality. Little is known about any potential difference in stroke risk between transradial (TR) and transfemoral (TF) approaches. We explored this question through a systematic review and meta-analysis.

Methods

MEDLINE, EMBASE, and PubMed were searched from 1980 to June 2022. Randomized trials and observational studies comparing radial versus femoral access CC or intervention that reported stroke events were included. A random-effects model was used for analysis.

Results

The total population in our 41 pooled studies comprised 1 112 136 patients – average age 65 years, women averaging 27% in TR and 31% in TF approaches. Primary analysis of 18 randomized–controlled trials (RCTs) that included a total of 45 844 patients showed that there was no statistical significance in stroke outcomes between the TR approach and the TF approach [odds ratio (OR) 0.71, 95% confidence interval (CI) 0.48–1.06, P-value = 0.013, I
2 = 47.7%]. Furthermore, meta-regression analysis of RCTs including procedural duration between those two access sites showed no significance in stroke outcomes (OR 1.08, 95% CI 0.86–1.34, P-value = 0.921, I
2 = 0.0%).

Conclusions

There was no significant difference in stroke outcomes between the TR approach and the TF approach.
Ethical Communication in Healthcare Organizations
Authors:   Craiova University, Craiova, Romania, Predilă Ana-Maria
Published: July 2023

Today, sustainability is an economic concept increasingly applied in the global economy, and communication is an inevitable part of every strategy. The events of recent years, marked by the COVID-19 pandemic, have led to the transformation of the business model in the medical sector by including ethical communication as a main component. The article aims to analyze the ethical communication with patients in organizations in the medical sector to eliminate the high risks related to a sustainable medical act and only in this way will the conditions for realizing a relevant and viable medical act be created for the individual and society. The research was carried out by means of a questionnaire applied to patients from hospitals in Romania. The results prove that progress in the health sector has increased remarkably, and health management is better due to new knowledge about managing diseases and life-threatening problems for patients. Therefore, it is necessary to incorporate ethical principles in all communication activities in the medical sector globally. Ethical communication will determine an elimination of the risks related to the loss of the image of medical institutions, the occurrence of medical errors, and their related financial consequences.
Глава 8. ОСОБЕННОСТИ ТЕМПЕРАТУРНОГО РЕЖИМА ПРИБРЕЖНОЙ ЗОНЫ ПРИМОРСКОГО КРАЯ НА РУБЕЖЕ ВЕКОВ
Authors: Гайко Л.А.
Published: July 2023

По данным наблюдений на пяти гидрометеорологических станциях, расположенных вдоль морского побережья Приморья, проведено исследование пространственно-временной структуры среднемесячной температуры воды и воздуха за период 1960– 2020 гг. с целью выявления температурных особенностей района за три последних десятилетия (1991–2000; 2001–2010 и 2011–2020 гг.) на фоне базовой климатической нормы, вычисленной за тридцатилетний период, рекомендованный Всемирной метеорологической организацией (1961–1990), и являющейся показателем климатических колебаний. Сравнение аномалий среднемесячных температур за три последних десятилетия от базовой нормы показало, что отклонения температуры воды и воздуха на станциях в основном были выше базовой нормы, но происходили они не равномерно, а носили волнообразный характер. При исследовании межгодового хода температуры воды, и воздуха на всех станциях был выявлен положительный значимый линейный тренд. Полученные результаты подтверждают, что в современный период в этом регионе прослеживается тенденция роста температурного фона. Ключевые слова: аномалии температуры; гидрометеорологическая станция; климатическая норма; температура поверхностного слоя морской воды; температура воздуха; температурный тренд.
Post-Soviet Ukraine in the global grain market: supplies for the poor?
Authors: Degterev D. A. , Kurylev K. P.
Published: July 2023

The authors of the paper examine the problem of the participation of post-Soviet Ukraine in the global grain trade basing on a critical analysis and using extensive statistical data. Grain crops have traditionally occupied the most important place in the agro-industrial complex of Ukraine. Ever since Soviet times, the image of the “all-Union granary” has been entrenched in it, which was especially actively exploited in the last years of the existence of the USSR by nationalist elements, becoming a program for them in the fi ght against Moscow. In fact, the Ukrainian SSR only until the early 1930s was the main base for the production of marketable grain in the USSR. Subsequently, larger grain bases were formed in the RSFSR and KazSSR. After the start of the Special Military Operation, the thesis about Ukrainian grain as a central element of global food security again became a popular narrative and was used against the Russian Federation as part of a global information campaign. This strategic disinformation was intended to infl uence Russia’s actions in the framework of the “grain deal”. The purpose of the study is to fi nd an answer to the question of the extent to which the positions of the Ukrainian side actually correspond to realities. Based on the results of the study, the authors come to the conclusion that the decisive role of Ukraine declared by offi cial Kiev and the West in the supply of grain to global markets is exaggerated. The bulk of the grain is not sent to those countries that are experiencing serious problems with hunger and are vitally dependent on Ukrainian supplies.
Russian Policy in the face of global uncertainty: challenges and opportunit
Authors: Zhiltsov S. S.
Published: July 2023

Since February 2022, the foreign policy of the Russian Federation has been carried out in a fundamentally new reality. Contradictions between Russia and Western states have escalated. The reason for the escalation is the policy of the West, which in the last decade has consistently taken steps aimed at changing the current system in the fi eld of maintaining global security and stability in international relations. The United States began to implement a course focused on preserving its dominant position in world politics and the economy. The political leadership of the United States strives to achieve these goals by putting pressure on their partners and geopolitical competitors, primarily Russia and China. Such US aspirations have provoked opposition from Russia, which has faced new challenges since March 2014 following the reunifi cation of Crimea with the Russian state. After that, the West radically revised its political course towards Russia and began to implement the sanctions policy. The pressure on Russia has led to growing tensions with the West, and more recently to open confrontation. The provocative measures taken to preserve the confl ict in the Donbass were supplemented by preparations for an armed confl ict between Ukraine and Russia. Moreover, the West purposefully pushed Kyiv to a military confl ict with the Russian Federation, which after February 2022 was forced to radically revise its approaches to foreign policy. The intensifi ed confrontation with the West has set the task for Russia to revise its foreign policy in many areas. In particular, Russia began to pursue a new energy and economic policy and to expand contacts with non-Western states. At the same time, geopolitical turbulence provides Russia with new opportunities. In the fi eld of international relations, the Russian Federation have a chance to reduce its dependence on the West, which for a long time acted as the main foreign policy partner. In this sense, Russia’s relations with non-Western states open up new opportunities for defending its geopolitical positions.
On the History of Religious Cults of Pisidia: rock votive reliefs
Authors: Pashkova Anastasiya Yur'evna
Published: July 2023

This article examines a group of religious images, namely votive reliefs carved in rocks, discovered during field research in Pisidia, through the prism of the collective memory of religious cults. Our goal is, on the one hand, to better understand their significance in the local cult, and on the other hand, to consider some ways of perceiving and studying such reliefs over time. The object of consideration in this article will be the rock votive reliefs of Pisidia, which will clarify some aspects of the evolution of religious cults of Pisidia in connection with its history, starting from Hellenistic and ending with Roman times. Religious cults are a topic of great importance for researchers who study ancient religion and history, as well as engage in archaeological excavations. Each of the components of this problem acts as a useful basis for conducting research, but in the process of their joint consideration, they become a powerful tool for understanding the human relationship with the divine. Based on the study of rock votive reliefs, it can be concluded that the functions possessed by the cult and ritual practices of Roman Pisidia were directly related to the audience. These functions inevitably changed over time and could be interpreted differently by different people or even by the same people in different cases.
Three-stage periodization of the history of nationalism of Miroslav Hroch as an "ideal model" and the prospects for its application to Iranian historical studies
Authors: Kyrchanoff Maksym Waler'evich
Published: July 2023

The author analyzes the features and contradictions in the development of Iranian nationalism historical forms in contexts of the ideal models proposed in modernist historiography. The article focuses on the problems of nationalism’s inability to become the dominant political force that constructs the main features of the societal and state developments in Iran. The article is an attempt to transplant classical theories of nationalism into Iranian historical and cultural contexts. The author uses a three-stage “ideal” model of the development of nationalism originally proposed by Miroslav Hroch. Using the modernist approach of Miroslav Hroch, the author presumes that since the 19th century, traditions of political and ethnic nationalism developed in Iran when Qajars and Pahlavi dynasties actualized various strategies of nationalist modernization. The article presents a comparative analysis of various historical forms of Iranian nationalism in the context of the constructivist approach, formulated in the three-stage periodization of Miroslav Hroch. It is assumed that the nationalist modernization of the Qajars and Pahlavi in Iranian historiography is perceived through the prism of a constructivist approach. Therefore, the causes and forms of the crisis of the nationalist project in Iran are also analyzed with use of the “ideal” chronology of nationalism formulated by M. Hroch in contexts of the competition between the political principles of the nation and the religious ideals of the Ummah.
Section of monuments of Science and technology VOOPIK: history and main activities (on the example of the Sverdlovsk and Chelyabinsk regions)
Authors: Lakhtionova Elizaveta Sergeevna
Published: July 2023

The object of the study is the section of monuments of science and technology of the VOOPIK. The subject is the activity of the section of monuments of science and technology for the identification, study, accounting, preservation and updating of the corresponding category of monuments. The purpose of the study is to reconstruct the history of the emergence and functioning of this structural unit in the 1960s-1980s. The territorial framework is limited to the Sverdlovsk and Chelyabinsk regions, the leading industrial regions of the Urals, on the territory of which there were a large number of monuments of science and technology, monuments of industrial heritage. The author studies the history of the formation of the section of monuments of science and technology, and also gives a description of various types of its activities on the materials of the Sverdlovsk and Chelyabinsk regions. The problem posed has not yet been the subject of special study, and has only been touched upon in the context of the study of history in general of the All-Russian Society for the Protection of Historical and Cultural Monuments and its regional branches, in particular. This determines the scientific novelty of the article. The source material is represented by archival materials, many of which are being introduced into scientific circulation for the first time, for example, unique information about the project to create a Museum of the History of Science and Technology in Chelyabinsk. The author comes to the conclusion that there were both similar directions and significant differences in the activities of these sections. This was determined by several reasons. Of great importance was the personal factor, which also influenced the effectiveness of the functioning of the section of monuments of science and technology
Kamrai tachycardiák epikardiális ablációja: esetbemutatás és irodalmi áttekintés
Authors: Szilágyi Gergő , Csanádi Zoltán , Clemens Marcell
Published: July 2023

Kamrai tachycardiák (KT) gyakran fordulnak elő a cardiomyopathiák különböző formáiban. Emiatt, primer vagy szekunder prevenciós indikációban ICD-beültetés szükséges, azonban amennyiben antiaritmiás szer mellett is halmozott ICD-működéseket tapasztalunk, a kamrai tachycardia katéterablációja jön szóba. Egyes esetekben primer beavatkozásként, vagy az endokardiális abláció sikertelensége esetén annak kiegészítéseként epikardiális abláció válhat szükségessé. 48 éves dilatatív cardiomyopathiás betegünknél primer prevenciós indikációban VVI ICD-beültetés történt. KT okozta halmozott sokkleadás miatt amiodaronkezelés csak átmeneti sikert hozott, elektromos vihar miatt endokardiálisan végeztünk ablációt, amely kapcsán a bal kamra posterior falán történt ablációkat követőn klinikai KT-t nem tudtunk indítani. 2 hónappal a beavatkozást követően ismét elektromos vihar miatt került hospitalizációra, amiodaron- és mexiletinterápia hatástalansága miatt kombinált endo-epikardiális térképezést követően epikardiálisan is kiterjedt hegesedést találtunk. Ezen a területen végzett ablációkat követően klinikai ritmuszavart indukálni nem tudtunk. Utánkövetése során per os amiodaronkezelés mellett a kamrai tachycardiák száma jelentősen lecsökkent, a csak ritkán jelentkező tartós ritmuszavarokat ATP szünteti. Az epikardiális aritmiaszubsztrát egyes cardiomyopathiákban – így a NICM-ben is – friss tanulmányok alapján gyakori, így primeren vagy az endokardiális abláció kiegészítéseként szükség lehet epikardiális ablációra is. Multricentrikus tanulmányok alapján az epikardiális abláció sikeraránya gyakorlott centrumokban magas, a szövődmények aránya pedig nem magasabb az endokardiális megközelítéshez képest.
Sternotomia S-ICD-t viselő beteg esetében
Authors: Németh Marianna , Daróczi László , Osztheimer István , Parázs Nóra , Hartyánszky István , Gellér László , Merkely Béla , Zima Endre
Published: July 2023

Az utóbbi évtizedben a szubkután implantálható kardioverter defibrillátorok (S-ICD) az együregű transzvénás ICD-rendszerek megfelelő alternatíváivá váltak válogatott betegek esetében. Korlátozottak azonban a tapasztalatok azon S-ICD-vel élő betegekkel kapcsolatban, akiknél sternotomia végzése szükséges. Szívműtét során emiatt aggályok merülhetnek fel az elektróda károsodása, az elektróda újra elhelyezése, valamint a szegycsontzáró drótok és az elektróda között esetlegesen kialakuló interferencia miatt.
A szívinfarktus miatt kezelt betegek ellátásának és prognózisának fontosabb adatai Nemzeti Szívinfarktus Regiszter – 2022
Authors: Jánosi András
Published: July 2023

A Nemzeti Szívinfarktus Regiszter (NSZR) az első és mindezidáig az egyetlen kardiológiai regiszter, amely évi rendszerességgel számot ad munkájáról. 2022-ben – az előző évekhez viszonyítva – csökkent az infarktus fődiagnózissal finanszírozott kezelések és a regisztrált események száma. Az infarktusellátás minőségi paraméterei (a panasz kezdete és az érmegnyitás között eltelt idő, a primer transzport aránya, katéteres érmegnyitás gyakorisága, a katéteres beavatkozás szövődményei, a távozáskor javasolt gyógyszeres kezelés, a betegek 30 napos halálozásának aránya) nem változtak.
Ortho O-Annulated AzaBenzannulated PeryleneDiimide and BisAzaCoroneneDiimide
Authors: David Arthur H. G. , Shymon Daryna , Melville Hayley , Accou Lou-Ann , Gapin Adèle , Allain Magali , Alévêque Olivier , Force Maximilien , Grosjean Alexis , Hudhomme Pietrick , Le Bras Laura , Goujon Antoine
Published: July 2023

The development of new n-type organic semiconductors is crucial to the development of organic electronics. The introduction of heteroatoms into electron-acceptor units enables their properties to be fine-tuned and new applications to emerge. In this study, we present the preparation of BisAzaCoroneneDiimide derivatives annulated by the insertion of oxygen in their ortho position. These compounds exhibit high planarity and their properties are sensitive to the extension of their π-system. Their performance in preliminary organic electronics studies is also reported.
Use of Emerging C–H Functionalization Methods to Implement Strategies for the Divergent Total Syntheses of Bridged Polycyclic Natural Products
Authors: Sennari Goh , Sarpong Richmond
Published: July 2023

Carbon–hydrogen (C–H) bonds are ubiquitous in complex natural products. Over the past three decades, many methods to convert C–H bonds distal from functional groups, which were generally considered inert, have been developed. These advances now enable selective peripheral functionalizations at a late-stage. The direct engagement of traditionally unreactive C–H bonds in reactions expands chemical space by reducing functional group interconversions. As such, C–H functionalization serves as a powerful tool in medicinal and agrochemical chemistry as well as in the total synthesis of natural products where diversification to a broad array of compounds from a common intermediate is often desired. In this Account, we detail the thought processes and design principles that relied on emerging methods for C–H functionalization to prepare a wide range of bridged, polycyclic, natural products in the cephalotane and longibornane families from a common intermediate in each case.
Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form
Authors: Nerdy Nerdy , Margata Linda , Zebua Nilsya Febrika , Lestari Puji , Bakri Tedy Kurniawan , Yusuf Faisal , Aulianshah Vonna
Published: July 2023

The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenicol in the capsule dosage form. The sample analysis showed that all analyzed thiamphenicol in capsule dosage form showed good results both qualitatively and quantitatively. Qualitatively all the samples analyzed showed a specific peak at specific positions and specific wavenumbers. These results meet the requirements for containing thiamphenicol in the dosage form. Quantitatively all the samples analyzed ranged from 97.97% to 102.24% by peak height and peak area. These results meet the requirements for active substance levels in general preparations within 90.0% to 110.0%. The method validation for peak height and peak area showed that the accuracy parameter had a recovery percentage of 100.28% and 100.41% (between 98.0% to 102.0%), the precision parameter with a relative standard deviation of 0.31% and 0.37% (not more than 2.0%), and the linearity parameter with a correlation coefficient of 0.9999 and 0.9997 (not less than 0.99). The limit of detection value was 0.2971 mg/mL and 0.5338 mg/mL, the limit of quantitation value was 0.9004 mg/mL and 1.6176 mg/mL, the range for both was 80% to 120%, and the specificity for both met the requirement. The Fourier Transform Infrared method has been successfully developed, applied, and validated for qualitative analysis and quantitative analysis of thiamphenicol in capsule dosage form.
Dynamics of Extreme Rainfall and Its Impact on Forest and Land Fires in the Eastern Coast of Sumatra
Authors: Akhsan Hamdi , Irfan Muhammad , Supari Supari , Iskandar Iskhaq
Published: July 2023

This article examines the extreme climate events on the Eastern Coast of Sumatra over four decades (1981-2019) based on the extreme rainfall index defined using the Expert Team on Climate Change Detection and Indices (ETCCDI). The indices used include Consecutive Dry Day (CDD and the total rainfall per year (PRCPTOT). Theses indices were calculated and are based on the daily observation data from eight quality-controlled weather stations. While overall trends in extreme rainfall indices are not significant, there is a noticeable trend towards drought, with CDD rising by 1.23 days per decade and PRCPTOT decreased by 3.16 mm/year. The correlation between the Dipole Mode Index (DMI) and extreme rainfall indices in the August-September-October-November (ASON) period was positive, with CDD increasing with the more positive DMI value. On the other hand, the PRCPTOT index showed a decrease as the DMI more positive. The ENSO index and CDD are positively correlated during the dry season, while ENSO index negatively correlates with PRCPTOT. The duration of CDD during El Niño/positive Indian Ocean Dipole (IOD) events in 1997, 2015, and 2019 had significant impact on the forest and land fires on the Eastern Coast of Sumatra. The results are useful for policymakers in preventing forest and land fires on the Eastern Coast of Sumatra.
Isolation and Molecular Identification of Direct Red 80 Synthetic Dye Degradation Bacteria from Palembang Indonesia Jumputan Cloth Industrial Waste
Authors: Muharni Muharni , Nurnawati Elisa , Yohandini Heni , Widjajanti Hary
Published: July 2023

Industrial waste from Jumputan cloth production pose a significant risk to environmental safety due to their toxic synthetic dye content. Several studies have shown that the presence of bacteria in these materials plays a very important role in decolorization process of the constituent dye. Therefore, this study aims to isolate bacteria with the ability to decolorize direct red 80 from Jumputan cloth industrial waste. Characterization of isolates was carried out macroscopically, microscopically, and biochemically, followed by molecular identification using the 16S rRNA gene. Decolorization effects of the samples on red dye 80 were then assessed using a spectrophotometer at a maximum wavelength of 528 nm. The results showed that 6 bacteria isolates can degrade dye, with decolorizing power ranging from 26.33±0.94 - 73.67±0.47. The highest potential for decolorizing waste synthetic dye is seen in isolate BD 05. Phylogenetic analysis showed that there were 3 genera of bacteria among the samples obtained, namely Bacillus, Aeromonas, and Pseudomonas. These bacteria were closely related to Bacillus tropicus, Areomonas jandaei, and Pseudomonas stutzeri. Pseudomonas stutzeri (BD 05) has the highest potential in handling jumputan industrial waste.
Development and Validation GC/MS Method for Methamphetamine Analysis in Urine by Miniaturization QuEChERS
Authors: Aulia Soraya , Primaharinastiti Riesta , Purwanto Djoko Agus
Published: July 2023

This paper explains the development of a quick and easy gas chromatography (GC) approach to identify methamphetamine in urine. This research used gas chromatography with mass spectroscopy and a capillary column TG-5SILMS (5% phenyl methyl siloxane, 30 m x 0.32 x 25 m). The carrier gas flow rate was set at 1.0 mL/minute, the temperature inlet and detector had been set at 300°C, and the oven temperature was programmed to initiate at 50°C and held for 1.5 minutes before being raised to 300°C at a rate 40°C/minute and held for 3 minutes. Sample pre-treatment by modification of the QuEChERS method includes using a relatively large amount of inorganic salt, extraction volume and extraction cycle. The optimal conditions for processing a 400 uL urine sample were 160 mg magnesium sulphate, 40 mg sodium chloride, and 400 uL acetonitrile for organic solvent. According to the validation test, the detection limit for methamphetamine was 0.36 ug/mL; the quantitation limit was 1.09 ug/mL, and the calibration curve followed the regression line. y=1.0489x-3.7914, coefficient (r) was 0.9973. The recovery of the analyte spiked into urine at 5, 7 and 9 ug/mL on average was 100.5±2.33% for intraday dan 93.3±7.21% for interday. The precision was excellent, with an average coefficient of variation of 2.31%. The procedure was applied to four urine samples from drug users and the first abuser (25.51 ug/mL), the second abuser (15.05 ug/mL), the third abuser (17.72 ug/mL) and the last abuser (3.08 ug/mL) were all satisfactorily quantitated.
Hydroxyapatite-ZnO Biomimetic Toothpaste Formulation from Rice Snail Shell Waste
Authors: Intannia Wisaeni , Charlena Charlena , Suparto Irma Herawati
Published: July 2023

Toothpaste is a preparation for dental treatment to clean, beautify, and replace minerals that decay from the surface of the teeth. Prevention of damage to the mineral layer of the teeth, the addition of remineralizing agents to toothpaste preparations in the form of hydroxyapatite-ZnO composites is carried out. This study aims to synthesize and characterize hydroxyapatite-ZnO, as well as to formulate hydroxyapatite-ZnO toothpaste from rice field conch shell waste. Hydroxyapatite-ZnO composites have been successfully synthesized using the sol-gel method and characterized using X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), and Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). The XRD result obtained a crystal size of 59.90 nm with a crystallinity percentage of 68.85%. The absorption band at a wave number of 452 cm−1 is an indication that the ZnO compound has been successfully combined with hydroxyapatite. SEM-EDX analysis showed that the morphology of the compound was granular with a rough surface, uneven size, and shape. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria.
Coprecipitation Synthesis and Antimicrobial Effect Study of Europium Doped Spinel Manganese Ferrites Nanoparticles (MnEu0.1Fe1.9O4NPs)
Authors: Chidouh Amina , Tahraoui Tarek , Barhouchi Badra
Published: July 2023

Due to the high prevalence of micro-organisms resistant to conventional antimicrobials, the search for new antimicrobial drugs is underway, with nanoparticles being one of the options. This study reports for the first time the use of the coprecipitation method to synthesize europium (Eu) doped spinel manganese ferrites nanoparticles (MnEu0.1Fe1.9O4NPs). The purpose of this research is to determine the antimicrobial activity of MnEu0.1Fe1.9O4NPs. MnEu0.1Fe1.9O4NPs were analyzed using Fourier Transform Infrared Spectroscopy (FTIR), X Ray Diffraction (XRD), and Scanning Electron Microscopy (SEM) combined with Energy Dispersive X-Ray Analysis (EDX) to determine their structure, size, morphology and elemental compositions. The antimicrobial activity of synthesized nanoparticles was evaluated qualitatively using a diffusion disc on agar, followed by minimum inhibitory concentrations (MIC) determination. The findings show that all tested strains were adversely affected by the examined NPs, where E. coli exhibited the highest sensitivity to NPs, followed by S. aureus. The NPs displayed a moderate level of anti-candida action. MnEu0.1Fe1.9O4NPs could be exploited in biomedical usages.
Increasing the Solubility and Anti-Inflammatory Activity of Curcumin by Cocrystallization
Authors: Wicaksono Yudi , Barikah Kuni Zu’aimah , Yudatama Amanda Della , Maulia Havidhatul , Nuri Nuri , Setyawan Dwi
Published: July 2023

Curcumin (CUR) is a polyphenolic compound that exhibits potent anti-inflammatory activity. However, only a tiny amount of CUR is absorbed during oral administration, which is because CUR is difficult to dissolve in water. The aim of the research was to increase the solubility of CUR through the cocrystallization technique using isonicotinamide coformer (INIC) by solvent evaporation. Cocrystal characterization was carried out using a powder X-ray diffractometer (PXRD), a differential scanning calorimeter (DSC), a Fourier transform infrared spectrometer (FTIR), and a scanning electron microscope (SEM). Solubility was evaluated using the shaking method, while the anti-inflammatory activity test was carried out using the carrageenan induced mouse leg edema method. The resulting CUR-INIC (1:1) cocrystal has a diffractogram with new diffraction peaks of 2theta at 15.00, 16.22, and 22.89◦ compared to the individual diffractograms of CUR and INIC. In the cocrystal, CUR and INIC form intermolecular interactions of hydrogen bonds, resulting in a new solid phase with a melting point of 160.1◦C. The solubility of the CUR-INIC cocrystal in water was 73.1±0.23 ug/mL, which increased 14 times compared to the solubility of initial CUR, which was only 5.05±0.07 ug/mL. The CUR-INIC cocrystal showed a percentage of edema inhibition in mice (5 hours) 130% more potent than that of initial CUR. Therefore, CUR-INIC cocrystals can be used to improve CUR solubility to obtain more excellent anti-inflammatory effects.
Observation on the Application Effect of Targeted Infusion Safety Nursing in Inpatients with Cancer
Authors: Jin Xue , Li Wenfeng
Published: July 2023

Objective: To study the clinical effect of targeted infusion safety nursing during infusion of inpatients with cancer. Methods: From January 1, 2020, to January 1, 2023, a total of 6,614 infusion patients were treated in The First Affiliated Hospital of Wenzhou Medical University, and 300 inpatients with cancer were selected as the research objects and randomly divided into the observation group and the control group, with 150 patients in each group. The control group received routine infusion nursing, and the observation group received targeted infusion safety nursing. The targeted infusion safety nursing was judged by comparing the nursing quality assessment, incidence of adverse events, patient compliance, and patients’ mastery of infusion knowledge between the two groups. clinical effect. Results: After the targeted infusion safety nursing was given to the patients in the observation group, the patients in this group recognized the nursing quality, and the statistical score was higher than that in the control group; the incidence of adverse events in the observation group was lower than that in the control group. The compliance of the observation group was higher than that of the control group. The mastery of health knowledge in the observation group was also higher than that in the control group and the difference was statistically significant (P < 0.02). Conclusion: After implementing targeted infusion safety nursing for inpatients with cancer, it can effectively prevent the occurrence of adverse events, improve patient compliance, and increase the mastery of relevant knowledge of patients.
Aransemen Musik Angklung Diatonis: Studi Kasus Pada Karya Aransemen dan Pelatihan Musik Angklung
Authors: Qadaris Wildan , Ruchimat Ismet , Nalan Arthur S
Published: July 2023

Abstrak

Terdapat formulasi dalam aransemen musik angklung diatonis berikut pengembangan di

dalamnya. Formulasi tersebut dapat menjadi referensi bagi pelatih angklung maupun guru-guru

di berbagai sekolah yang bergerak dalam kegiatan intrakurikuler serta ekstrakurikuler musik

angklung diatonis. Artikel ini memaparkan pendekatan metodologis dalam aransemen musik

angklung diatonis dengan pelaksanaan yang akurat dan efisien serta penerapannya yang lebih

estetis. Tujuan artikel ini adalah untuk memberikan pendekatan metodis bagi praktisi angklung

dalam membuat sebuah karya aransemen. Arikel ini memaparkan tahapan-tahapan proses yang

harus dilalui oleh seorang arranger musik angklung dalam melakukan praktik aransemen

khususnya musik angklung diatonis. Hasil penelitian ini adalah berupa formulasi dalam teori

aransemen musik angklung yang dapat membantu para praktisi angklung dalam menentukan

langkah-langkah ketika memiliki keinginan untuk menciptakan sebuah karya aransemen musik

angklung diatonis. Tahapan tersebut meliputi: (1) kelompok unit angklung, (2) konsep

aransemen, (3) aransemen awal, (4) tahap akhir aransemen, (5) evaluasi dan revisi.

Kata kunci :aransemen, arranger, angklung, diatonis.