bluuebunny/crossref_metadata_2025 huggingface dataset:
Reinforcement Learning-Optimized Personalized Cancer Treatment Strategies: A Case Study of Lung Cancer
Authors: Zhou Chichun , Liu Zhaocong , Li Xinhui , Nai Shuncheng , Zhang Junpeng , Lan Yuanping , Li Lijuan , Liu Yi , Wang Bin , Liu Yaling
Published: October 2024

Personalized cancer treatment strategies (PCTS) tailor treatments on the basis of a patient’s health status, cancer type, and stage. By considering the evolving interactions of treatment options over time, PCTS seeks to balance cancer suppression with minimizing harm and maximizing therapeutic benefits. However, limited clinical trial resources limit the ability to explore optimal PCTSs fully through experimentation, presenting a significant challenge to their development. In this study, we introduce a "digital twin" model that integrates comprehensive patient health data, cancer characteristics, and individual treatment responses and employs reinforcement learning (RL) to identify the optimal PCTS. Using lung cancer as a case study, we calibrated model parameters for various demographic groups, cancer stages, and treatment options, utilizing real clinical data from the SEER dataset. The RL-optimized PCTS significantly outperformed traditional clinician decisions, leading to notable improvements in patient survival. For example, among women aged 45--64 years with stage IIIA, IIIB, IVA, and IVB lung cancer, survival increased by 46%, 59%, 23%, and 149%, respectively. Similarly, for men aged 45--64 years, survival improved by 108%, 97%, 40%, and 62%, respectively, across the same stages. This study lays a critical foundation for the use of AI in optimizing PCTS and paves the way for further research and clinical applications.
Imine based covalent adaptable networks from diacetone acrylamide polymerization
Authors: Chen Hanghang , hou Zihao , Li Liqiong , Deng Haoyu , Ouyang Yixue , Ye Dezhan , Jiang Xiancai
Published: October 2024

The construction of covalent adaptable networks (CANs) without the need for post-modification, complex monomer synthesis routes, or expensive materials is highly desirable for the practical application of dynamic covalent chemistry. In the present study, the commercially available acrylate monomer, diacetone acrylamide (DAAM), was initially polymerized using a traditional radical polymerization method. Subsequently, it was cross-linked with amine agents under hot-processing conditions to form aliphatic imine-based CANs. The resulting materials exhibited glass transition temperatures (Tg) in the range of 95 to 107°C, good thermal stability, mechanical and thermomechanical properties. All samples were amenable to mechanical recycling. Post-recycling, both the tensile strength and Young's Modulus exhibited a slight deterioration, retaining approximately 80% of their original properties. The results from gel content analysis and structural characterization of both pristine and recycled samples indicate that the observed reduction in mechanical properties and Tg (approximately 70°C) can be attributed to a decrease in the degree of cross-linking and the release of aliphatic ketone groups. Furthermore, all samples demonstrated degradability under acidic conditions, attributable to their aliphatic imine structure. By using this facile approach to prepare acrylate-based imine CANs, we establish an important framework for polymer materials that are both reprocessable and biodegradable.
Evaluation of proximate composition, and mineral content of five soybean varieties in two research centers
Authors: Ateye Mahamed Dol , Ali Abdulkarim Mohammed , Hassen Shamsedin Mahdi , Jama Hodo Mohamed
Published: October 2024

Soybean is a valuable source of high-quality protein and oil, widely used in human diets. This study aimed to evaluate the proximate composition and mineral content of soybean varieties from two Ethiopian research centers and Dolo-Ado. Mature soybean seeds were collected from Kelafo, Dolo-Ado, and local markets. Proximate composition (moisture, ash, fat, protein, fiber) and mineral content (calcium, iron, magnesium, zinc) were analyzed using standard methods, with triplicate measurements. Data were analyzed using Design Expert version 13 and Excel 2019. Moisture content ranged from 4.78–7.34%, protein 19.65–30.35%, fat 5.37–21.61%, and fiber 3.75–6.29%. Calcium ranged from 48.9–157.2 mg/100g, iron 5.37–12.06 mg/100g, magnesium 658.5–2429.1 mg/100g, and zinc 3.79–6.45 mg/100g. Varieties K-Pawa 1, K-Pawa 3, D-Pawa 3, and D-Gezale exhibited high nutritional value, making them suitable for addressing protein-energy malnutrition and mineral deficiencies, particularly in vulnerable populations such as infants and lactating mothers.
Unveiling the Dynamics of Alternative Investment Funds (AIFs): A Comprehensive Analysis of Their Role in Capital Formation in the Indian Financial Landscape
Authors: Paul Vethamuthu Richard
Published: October 2024

This study delves into the intricate dynamics of Alternative Investment Funds (AIFs) in the context of the Indian financial landscape. The primary focus is on understanding how these factors influence gross capital formation, making AIFs increasingly integral to capital-raising activities in the Indian economy. By employing pooled data, this research sheds light on the multifaceted investments made by AIFs and their role in shaping the future of capital formation. The study reveals that AIFs, with their encompassing categories I, II and III of investment avenues, can play a pivotal role in transforming traditional investment practices. The findings underscore the significance of AIFs in offering alternative avenues for investment, providing a way forward for traditional investors. The implications of these results extend to policy considerations, particularly for developing countries exploring innovative approaches to capital formation.
An Analysis of DEI Practices in the Sustainability Reports of Leading ESG Companies in Korea
Authors:   Human Engagement Institute, Kim Taesung , Baek Pyounggu
Published: October 2024

The purpose of this study was to identify the current status and characteristics of diversity, equity, and inclusion (DEI) activities implemented by companies in South Korea and to provide insights into future directions for development. To achieve this, the study analyzed the DEI-related activities of companies consistently rated as excellent in ESG management evaluations, based on their sustainability reports. Texts relevant to DEI from 86 sustainability reports for the year 2023, covering activities from January to December 2022, were collected and analyzed. The results revealed that, first, the term “D&I” is used more frequently than “DEI” in sustainability reports, and DEI is often presented in the context of human rights management. Second, within the Plan (input) - Do (execution) - See (output) framework, categories identified include in the Plan area: the establishment of DEI management principles, setting DEI promotion strategies, and constructing DEI governance; in the Do area: fostering a DEI organizational culture, DEI-based talent development, and DEI-based human resource management; and in the See (output) area: managing human diversity, board diversity, and DEI performance management. Based on the findings, both academic and practical implications were presented, along with suggestions for the future role of HRD in relation to DEI
A Study on the Implementation of ChatGPT in University Settings: Exploring the Experiences of Learners and Instructors
Authors:   Human Engagement Institute, Shin Sunae , Kim Jiwon , Shin Suhkyung
Published: October 2024

The study aims to explore ChatGPT's future role in university writing education and propose teaching strategies by analyzing the perceptions of instructors and learners in courses utilizing ChatGPT. Three instructors developed and analyzed a Chat-GPT-based writing course by conducting thematic interviews with six students. The results of the interview analysis are as follows: First, ChatGPT served as a tool not only to assist learners' activities but also to provide assistance in cognitive and metacognitive strategy development. Second, instructors found it challenging to provide timely and effective scaffolding in ChatGPT-based classes. Third, learners showed differences in their use of ChatGPT between individual and group activities, and it was particularly noted that ChatGPT facilitated learner engagement and had a positive impact during group activities. Recommendations include tailored scaffolding strategies for different learning activities and timely support strategies for instructors, focusing on ChatGPT's interaction with both learners and instructors
INFLUENCE OF MOUTH WASH AND BEVERAGE ON THE SURFACE ROUGHNESS AND COLOR-STABILITY OF ZIRCONIA RE-INFORCED LITHIUM DISLICATE AND SUPER-HIGH TRANSLUCENT ZIRCONIA
Authors: Thenukutty Faseela , Kallayil Anas
Published: October 2024

The goal of this study was to see how commercially available, commonly prescribed mouth rinse and black coffee affected the colour stability and surface roughness of Zolid fx, a recently introduced super high translucent zirconia, and Vitasuprinity, a zirconia reinforced lithium disilicate.To simulate 10 years of exposure to mouth-rinse solutions, Zolid fx and vitasuprinnity samples were immersed for 120 hours at a constant temperature of 37.C every 24 hours and the solutions were replenished, and immersion was continued up to 120 hours. After immersion, the samples were kept in an artificial salivary substitute until testing.A spectrophotometer was used to measure the colour change of the samples. The study employs a contact type spectrophotometer calibrated on white with D65 illumination and a geometric 2% observer curve. The CIE L*a*b* values were measured, and the average reading was calculated for each specimen, and the surface roughness was measured using a Mitutoyo SDA 350 profilometer over a transverse length of 4 mm and a cut-off value of 0.8 mm before and after immersion in the mouth rinse and black coffee. The measurements were repeated three times, and the mean values were computed. The findings were statistically examined.There were no significant differences in the colour of the samples before and after exposure to the mouth rinse, and the delta E value measured was less than 3, indicating that the difference was clinically insignificant. The surface roughness of the sample after immersion did not differ statistically between groups.As a result, it was concluded that Listerine can be safely prescribed and used in patients who have or are receiving Zolid fx and vitasuprinity restorations, and that black coffee does not stain them or affect their optical properties and surface texture, which can cause a perceptible amount of change.
GAME THEORY IN STARTUP STRATEGY: INSIGHTS INTO FINANCIAL AGREEMENTS, COMPETITIVE MARKETS, AND MARKET ENTRY TIMING
Authors: Agarwal Khushee
Published: October 2024

This research delves into the application of game theory in enhancing decision making within businesses by structuring data into a payoff matrix, for evaluating the relative benefits of cooperation and competition, among enterprises. The study illustrates that game theory contributes to shaping decisions and impacts the planning for a companys expansion. Business owners who understand game theory acquire perspectives on when to collaborate and compete in ventures. This insight is very useful, for firms that aim to thrive in the startup ecosystem. The paper will focus on the primary decisions such as the agreement with the venture capitalist making decisions in competitive markets and determining the optimal market entry timing.
ASSOCIATION ENTRE TROUBLE BIPOLAIRE ET MALADIE DE PARKINSON : A PROPOS DUN CAS
Authors:   Equipe de Recherche Pour La Sante Mentale, Service Universitaire Psychiatrique, CHU Mohamed VI, Marrakech., Farricha Hannan El , Hasna Zizi ,   Equipe de Recherche Pour La Sante Mentale, Service Universitaire Psychiatrique, CHU Mohamed VI, Marrakech., Fahiri Fatima Zahrae El ,   Equipe de Recherche Pour La Sante Mentale, Service Universitaire Psychiatrique, CHU Mohamed VI, Marrakech., Zineb Ennaciri ,   Equipe de Recherche Pour La Sante Mentale, Service Universitaire Psychiatrique, CHU Mohamed VI, Marrakech., and AdaliImane ,   Equipe de Recherche Pour La Sante Mentale, Service Universitaire Psychiatrique, CHU Mohamed VI, Marrakech., Fatiha Manoudi ,   Equipe de Recherche Pour La Sante Mentale, Service Universitaire Psychiatrique, CHU Mohamed VI, Marrakech.
Published: October 2024

La maladie de Parkinson (MP) et le trouble bipolaire(TB) sont deux maladies qui surviennent aux extremites opposees de la vie.Plusieurs etudes concluent a lexistence dun lien entre le TB et la MP : le TB est lie ou influence la MP et vice versa. En effet, lexposition aux antipsychotiques chez les sujets ayant un TB pourrait favoriser la survenue dune MP idiopathique et inversement, la levodopa , un medicament utilise contre la MP, active les recepteurs de la dopamine et peut induire la manie chez certaines personnes.Bien que lexplication ne soit pas claire, la voie dopaminergique est actuellement mise en evidence dans diverses etudes. Cette comorbidite expose a des enjeux diagnostiques et therapeutiques complexes, rendant la prise en charge de ces patients difficile. Dans cet article, nous presentons le cas dune patiente agee de 65ans, suivie pour une MP depuis 12 ans, hospitalisee pour tentative de suicide par ingestion massive de levodopadans un cadre depressif. Linterrogatoire a revele lexistence de troubles de lhumeur negliges qui ont precede de plusieurs annees lapparition de la MP.Levolution a ete favorable sous quetiapine.
Cuando el tejido del texto excede lo verdadero: la teoría plural del relato histórico en Odo Marquard
Authors: De Navascués Nicolás
Published: October 2024

El artículo desarrolla una interpretación del conjunto de la obra de Odo Marquard, exponente de la hermenéutica escéptica, desde la idea de la disciplina implícita en una consideración fuerte de la verdad histórica y la pretensión de sentido. Por tanto, es un estudio de filosofía política enfocado desde los problemas que la filosofía de la historia ha suscitado en la hermenéutica contemporánea. Después de tratar la cuestión de la veracidad en el campo histórico, defiendo que, para la convivencia política, es fundamental desimperializar la historia y ofrecer una práctica histórica desligada de una noción de “Verdad” que arrase con la discusión política.
Comparison of Plasma Corin Levels in Gestational Hypertensive Patients, Normotensive Pregnant and Normotensive Non-Pregnant Women
Authors: Humaira Fayyaz  , Al-Aqmer Noora Hassan Hezam , , Sibgha Zulfiqar
Published: October 2024

Background:  Multiple factors play role in gestational hypertension including vasopressin production and Renin-angiotensin-aldosterone system activation. Opposing these effects, corin plays an important role in mediating natriuretic peptide biosynthesis cascade which is an important factor in regulating fluid balance and blood pressure. Corin levels have been studied in relation to gestational hypertension and results were controversial.Objective:: This study aimed at comparing plasma corin levels in gestational hypertensive patients, normotensive pregnant women, and normotensive non-pregnant women.Methods: This was a cross sectional comparative study conducted for one year at Shaikh Zayed Medical Complex. By convenient sampling, ninety women aged 18-45 years were included; thirty pregnant (primigravida and multigravida) with gestational hypertension, thirty pregnant (primigravida and multigravida) normotensive women, and thirty non-pregnant normotensive women. Patients with gestational diabetes, renal diseases, hypertension before pregnancy, and other cardiovascular diseases were excluded. Informed consent was taken and demographic data was recorded. Three ml of blood was taken from each participant and corin levels were measured using ELISA kit. Data was analysed using SPSS 24.Results: A significant difference was found in BMI among the three groups with the gestational hypertensive patients having the highest BMI (p-value < 0.05). There was no significant difference in gravid and parity count between gestational hypertensive patients and pregnant normotensive women. No significant difference was found in corin levels among the three groups and there was no significant correlation between corin levels and age nor between corin levels and BMI.Conclusion: There is no significant difference in plasma corin levels amongst gestational hypertensive patients, normotensive pregnant women, and normotensive non-pregnant women.
Oasis urbanos en el desierto sudcaliforniano
Authors: Peña Azcona Ivett , Cariño Olvera Martha Micheline , Escalona Aguilar Miguel Ángel
Published: October 2024

Alcanzar la soberanía alimentaria en las ciudades es un desafío que se agudiza en ambientes áridos y aislados, como La Paz, Baja California Sur, México. Los habitantes originarios no practicaron la agricultura, por lo que la construcción de agroecosistemas oasianos fue indispensable para el autoabastecimiento de comunidades sedentarias, gracias a la complementariedad de la agrobiodiversidad, la ganadería extensiva y la pesca. Este sistema socioecológico perdió su centralidad en 1950 y desde entonces una acelerada inserción en la globalización ha generado una presión sobre la naturaleza e incrementado la vulnerabilidad en un territorio donde los efectos del cambio climático se agudizan, lo que compromete la alimentación y la salud de su población. Dilucidamos los derroteros iniciales que encaminan procesos de transiciones agroecológicas, resultado de una investigación con incidencia social, que buscan superar tal situación crítica. Mediante una metodología cualitativa y la investigación acción participante, con un enfoque interdisciplinario, caracterizamos prácticas urbanas y periurbanas capaces de territorializar transiciones agroecológicas y (re)construir oasis urbanos en la búsqueda de la soberanía alimentaria.
Relevancia de la inteligencia cultural en la calidad en el servicio al turismo internacional
Authors: Arjona Granados María del Pilar
Published: October 2024

Los actuales cambios en el escenario global repercuten en la conformación del turismo internacional en México. Los estudios de la Organización para la Cooperación y el Desarrollo Económico indican que las economías emergentes tendrán mayor presencia en el turismo en los próximos años. La presente investigación se enfoca en la validación de los elementos que inciden en la calidad en la provisión de servicios turísticos internacionales, a partir de la identificación y el análisis de los factores multiculturales que integran la inteligencia cultural. La metodología consiste en un estudio cualitativo exploratorio; la muestra se compone de expertos en turismo internacional familiarizados con la práctica, atención, sistemas y modelos de competitividad tanto en el sector público como en el privado. Los resultados se centran en la validación de los datos de las entrevistas a conocedores en el área con la literatura y la determinación de los factores que repercuten en la calidad del servicio y la competitividad del sector respecto a las necesidades multiculturales de los visitantes extranjeros.
Explicar la frontera a los no fronterizos
Authors: Arvide Basterra Margarita Isabel
Published: October 2024

Reseña del libro Guerra y paz en la frontera del Bravo (1830-1880), escrito por Miguel Ángel González Quiroga y publicado en su versión en español, por la Universidad Autónoma de Nuevo León el año 2023.
Booming Artificial Intelligence in Oral Cancer Diagnosis: From Image Processing to Stage Classification
Authors: Gopalakrishnan Shankari , Prabhu Dhamodharan , Gopinath Subash C.B.
Published: October 2024

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Orexin Receptor System: Molecular Insights and Therapeutic Implications
Authors: Sharma Prachi , Choudhary Gunjan , Sachdeva Monika , Mehta Geetika , Tripathi Rashmi
Published: October 2024

Neuropeptide neurotransmitters, orexins, are produced in the lateral hypothalamus.
They are extensively dispersed throughout the central nervous system, except the cerebellum and
peripheral nervous system. Orexin works by attaching themselves to G-protein-coupled receptors:
orexin receptor 1 (OXR1) & orexin receptor 2 (OXR2). They play a role in the regulation of energy
homeostasis, appetite, sleep-wake cycles, and other disorders like cancer, ischemic stroke, depression,
Alzheimer's disease, and narcolepsy. Prepro-orexin peptide undergoes proteolytic breakdown
to create these neurotransmitters. Orexin receptor antagonists decrease both non-rapid eye
movement and rapid eye movement sleep, which increases awake through the lateral preoptic region.
It encourages eating and supports the control of feeding habits, thus can be used in the treatment
of obesity. In Alzheimer's disease, orexin enhances tau protein-mediated neurodegeneration
and beta-amyloid buildup by interacting with the biomarkers of the illness found in the cerebrospinal
fluid (beta-amyloid/tau proteins). It also lessens neuroinflammation, enhances cognitive performance,
and prevents the formation of plaque, which contains beta-amyloid and tau proteins.
A Review of Published Cases Regarding the Amphotericin B Deoxycholate Overdose in the Pediatric Population and a Case Report
Authors: Shahrabi Marzieh , Savadi Sana , Tavakolifar Yousef , Solduzian Mohammad
Published: October 2024

Considering the fact that two available and commonly used formulations of amphotericin
B could be used instead of each other by mistake. Also, an updated and comprehensive data
regarding management of this medication error was not available; the current review was conducted
to gather available data among the pediatric population and discuss management and outcome
of patients in case such an error occurs. We review all the cases of amphotericin B overdose
which reported in PubMed and google scholar so far then discuss an 8-years-old girl diagnosed
with Ewing sarcoma who inadvertently received five times more than therapeutic dose of amphotericin
B deoxycholate (5mg/kg/day).In total, ten of the cases were exactly matched to our purpose
of the study. In our case, fluid and electrolyte management was aggressively undertaken and
she was put under cardiac monitoring for 7 days following detection of the medication error. Finally,
she was discharged from hospital with stable condition. Reviewed data in this manuscript
showed that amphotericin B deoxycholate overdose could cause severe complications and lead to
cardio toxicity, electrolyte imbalance and death. Aggressive cardiac, fluid and electrolyte monitoring
and management of any problem as soon as they were detected was the pathway followed by
the authors of this review and others who faced this medication error. The role of NAC and hydrocortisone
in the managing amphotericin B deoxycholate overdose requires further investigation.
A Comprehensive Review on Insect Repellent Agents: Medicinal Plants and Synthetic Compounds
Authors: Yadav Deepak Kumar , Rathee Sunny , Sharma Versha , Patil Umesh K.
Published: October 2024

Plant-based repellents have been used for generations as personal protection against mosquitoes. Ethnobotanical studies provide valuable knowledge for developing natural prod-ucts. Commercial repellents with plant-based ingredients are popular, but insufficient studies follow Pesticide Evaluation Scheme WHO guidelines. Further standardized studies are needed to evaluate repellent compounds and develop high-repellency and safe products. Essential Oils (EOs) from aromatic plants have gained popularity as low-risk insecticides due to their low toxicity and short environmental persistence. These plant-derived EOs, produced through steam distillation, have repellent, insecticidal, and growth-reducing effects on various insects. They control phytophagous insects, bite flies, and home and garden insects. US registration is the main hurdle for new EOs. This review explores the use of essential oils from plants as a natural repellent, focusing on their effectiveness and synergistic effects. Essential oils are vol-atile mixtures of hydrocarbons with diverse functional groups, and their effectiveness is linked to monoterpenes and sesquiterpenes. Synergistic effects can improve their effectiveness, and the use of other natural products, like vanillin, can increase protection time. Cymbopogon spp., Ocimum spp., and Eucalyptus spp. are among the most promising plant families.
Revolutionizing Quinolone Development for DNA Gyrase Targeting; Discovering the Promising Approach to Fighting Microbial Infections
Authors: . Shafiurrahman , Hasan Syed Misbahul , Singh Kuldeep , Kumar Arun , . Suvaiv , Bano Jeba , Shahanawaz Mo. , Ahmad Sana , Kushwaha Shom Prakash
Published: October 2024

DNA gyrase is a type II topoisomerase enzyme that can cause negative supercoiling in DNA by using the energy produced by ATP hydrolysis. There are two main types of topoi-somerases: type I and type II. Type I enzymes cut a single strand of DNA and are further clas-sified as type IA if they connect to a 5′ phosphate of DNA, or type IB if they link to a 3′ phos-phate. Type II topoisomerases break both strands, creating a staggered double-strand break.
Antimicrobial resistance is a major concern for the global healthcare system. Resistance is the ability of microorganisms to neutralize and withstand antimicrobial drugs previously used to treat microbial infections. Some known classes of DNA gyrase inhibitors are coumarins, cyclo-thialidines, and quinolones. Antimicrobial medicines such as quinolones have been widely used to treat microbiological diseases. However, the increased use of quinolones has led to the emer-gence of quinolone-resistant bacteria, which poses a serious risk to public health. Microorgan-isms can cause resistance due to changes in the target enzymes, DNA gyrase, and topoisomerase IV, which are responsible for transcription and DNA replication. Additionally, differences in drug entry and efflux may also play a role in resistance. Plasmids that produce the Qnr protein can mediate resistance to quinolones by protecting the quinolone targets from inhibition. This review aims to revolutionize the discovery of quinolone-based antibiotics, specifically targeting DNA gyrase, a critical enzyme in bacterial DNA replication, to enhance the efficacy and spec-ificity of anti-microbail agents against microbial infections.
Correlation between Cognitive Impairment and Peripheral Biomarkers - Significance of Phosphorylated Tau and Amyloid-β in Alzheimer’s Disease: A New Insight
Authors: Sarkar Subhajit , Bhui Utpal , Kumar Bimlesh , Ashique Sumel , Kumar Prashant , Sharma Himanshu , Bhowmick Mithun , Pal Radheshyam , Kumar Tinku
Published: October 2024

The correlation between elevated levels of amyloid-β and phosphorylated
tau (p-tau) protein and AD is widely recognized. A rise in pTau and amyloid-
β levels aids in separating AD from other neurodegenerative conditions. In
this study, we have assessed the correlation between cognitive impairment and
peripheral biomarkers, tau and amyloid-β levels, in AD patients with mild
Alzheimer's disease in order to develop protein-based markers in a more useful
way. An enzyme-linked immunosorbent assay has been used to determine the
levels of tau and p-tau in the serum of the different groups and it has revealed
their levels to be noticeably greater in AD compared to mild AD and even higher
compared to elderly controls. Based on the cutoff levels for tau, p-tau, and
amyloid-β in patients with AD and mild AD, having high sensitivity and specificity,
which have been described in numerous studies by respective International
Research Groups (with the greatest number of pieces of available evidence),
the plasma concentration of these proteins can be used as a diagnostic indicator
for AD and mild AD. These levels may also offer a practical guide to their implementation
in the clinical routine.
Data Security and Privacy Preservation in Cloud-Based IoT Technologies: an Analysis of Risks and the Creation of Robust Countermeasures
Authors: Pathak Mayank , Mishra Kamta Nath , Singh Satya Prakash
Published: October 2024

The Internet of Things (IoT) is a revolutionary technology being used in many different
industries to improve productivity, automation, and comfort of the user in the cloud and
distributed computing settings. Cloud computing is essential because it makes data management
and storage more effective by automatically storing and examining the enormous
amounts of data generated by Internet of Things applications. End users, companies, and government
data are consequently migrating to the cloud at an increasing rate. A survey of the literature,
however, reveals a variety of issues, including data integrity, confidentiality, authentication,
and threat identification, that must be resolved to improve data security and privacy. To
effectively address contemporary data security concerns, the existing approaches need to be
improved. Ensuring secure end-to-end data transmission in a cloud-IoT situation requires innovative
and dependable protocol architecture. New technologies that address some of the issues
related to cloud data include edge computing, fog, blockchain, and machine learning. This paper
provides a thorough examination of security risks, classifying them and suggesting possible
defenses to safeguard cloud-IoT data. It also highlights innovative approaches, such as blockchain
technology and machine learning, applied to privacy and data security. The paper also
explores existing issues with respect to data privacy and security in today's cloud-IoT environments.
It suggests possible future directions, including the need for end-user authentication,
enhanced security, and procedures for recovering data in the event of an attack.
Introduction
Authors: Cheng Y.M. , Law C.W.
Published: October 2024

This chapter introduces the basic considerations for the structural forms of tall
buildings and the history and lists of tall buildings in Hong Kong. A general introduction to the
structure of the whole book is also included to facilitate the readers
Approaches and Methods for Analysis of Building Structure
Authors: Cheng Y.M. , Law C.W.
Published: October 2024

This chapter introduces the classical methods as well as the modern computational
approach for tall building analysis. The structural behaviour of basic structural elements as well
as sub-systems and joints are discussed in detail. The second-order effect with respect to large
deformation which is important for steel structures is also discussed in this chapter. The
materials in this chapter can greatly enhance the application of computer programs for the
analysis of complicated tall buildings.
Criteria for Foundation Options Selection
Authors: Cheng Y.M. , Law C.W.
Published: October 2024

This chapter gives an introduction to the various considerations in the selection of
foundations, which include cost, geology, settlement, loadings, and the surrounding buildings.
Shallow Foundation Analysis and Design
Authors: Cheng Y.M. , Law C.W.
Published: October 2024

This chapter discusses the ultimate limit state, and serviceability limit state design
of shallow foundation, which is further complimented by site tests. Classical and computational
methods for simple footing and raft foundation analysis and design are discussed in detail in
sthis chapter.
Pile Foundation Analysis, Design and Construction
Authors: Cheng Y.M. , Law C.W.
Published: October 2024

In this chapter, different types of piles are classified, with the method of construction
and design. The analysis and design of piles include vertical and lateral load analysis for single
piles and pile groups. A detailed discussion of the various field pile tests and the methods for
interpretation are included to assist the readers in the field control of pile installation.
Design and Construction of Buildings and Foundations with Illustrative Examples
Authors: Cheng Y. M. , Law C. W.
Published: October 2024

This book is an essential guide to analysis and design of tall buildings and foundations. The book covers the basic consideration of tall buildings, selection of a suitable structural form, structural materials, and analytical methods for several types of construction loadings. The last chapter of this book presents an illustrated case study for learners. An appendix of different structural analysis calculations rounds up the book. The detailed analysis and learning material presented in the book is intended to enable readers to master the basics and understand how to execute practical civil engineering projects.

Key features:
Covers the essentials of skyscraper design and construction in detail with a focus on learning.
Covers building modelling parameters and criteria with design reports and computer inputs.
Includes analysis and notes for foundation layout, loadings and the excavation and lateral support system (ELS).
Includes more than 250 detailed illustrations of concepts, construction plans and photos from real projects.
Includes references and appendices for advanced readers.
Includes more details than most of the similar texts, with practical guidelines based on references from many buildings and foundation projects.
The authors have extensive research and practical experience of buildings and foundation analysis and design in Hong Kong, and have actively served as regional engineering committee members overseeing structural and foundation disciplines.
Imperforata Hymen: Secondary Urinary Retention due to Hematocolpos Compression in a 13-Year-Old Woman
Authors: Sentosa I Gede Bagus , Kurniawan Rommy Andika
Published: October 2024

Imperforate hymen is a rare congenital anomaly in which the hymen completely covers the vaginal opening, caused by the failure of vaginal plate canalization during the embryonic period. This article reported a 13-year-old girl with a chief complaint of cyclic monthly lower abdominal pain, suprapubic pain, and inability to urinate. She denied prior menstruation. Cystic mass was palpated in the suprapubic area, and the hymen was seen covering the entire vaginal introitus. Hematometra and hematocolpos were found on abdominal ultrasonography and the patient was diagnosed with imperforate hymen. Hymenectomy was performed and she had regular menstruation afterwards. If left untreated, it can lead to morbidities such as infection, endometriosis, subfertility, and kidney failure. It is essential for clinicians to consider imperforate hymen as the differential diagnosis and examine the external genitalia, especially in adolescents with cyclic monthly lower abdominal pain and amenorrhea.
Examining the Relationship between Infection Control Practices and ESBL Bacterial Carriage in Healthcare Workers
Authors: Ayunisih Lintang Sekar , Krisniawati Nia , Wicaksono Madya Ardi , Hestiyani Rani Afifah Nur , Widhi Anriani Puspita Karunia Ning
Published: October 2024

The Enterobacteriaceae family widely produces Extended Spectrum Beta-Lactamase (ESBL), and infection by ESBL-producing bacteria can significantly increase morbidity, complicate therapeutic difficulties, escalating healthcare costs, and increase mortality rates. Transmission of these bacteria within the hospital environment may lead to the prevalence of ESBL-producing bacterial carriers among healthcare workers. Health workers' infection prevention and control (IPC) behavior plays a role in transmitting these pathogenic bacteria. This study aimed to determine the relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital. This research used an observational analytic approach with a cross-sectional method. The sampling technique involved purposive sampling, resulting in a total sample of 61 people. Data were obtained by completing an IPC behavior questionnaire and collecting rectal swab samples cultured on CHROM ESBL Agar media. Statistical analysis was done using the Mann-Whitney test. The research identified a prevalence of 13.1% (8/61) ESBL-producing bacterial carriers among health workers at Banjarnegara Islamic Hospital. However, based on statistical analysis, the p-value was 0.664, leading to the rejection of the hypothesis (accepted if p-value <0.05). In conclusion, there is no significant relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital.
“Open the world of art to residents and guests of the city” about the artistic work of N. I. Verkhoturov in the Irkutsk province at the turn of the 19th – 20th centuries
Authors: Tkachev V. V.
Published: October 2024

Relevance. Throughout the entire period of development of the urban environment, artists changed their attitude towards artistic spaces. N. I. Verkhoturov is one of many who not only sought to increase the interest of residents in his works, but also to create an artistic environment in the Irkutsk province. These aspects strengthen and intensify the work on studying the artistic heritage of the master, which has been preserved in the archives and museums of Irkutsk.

The purpose is to present the work of N. I. Verkhoturov on creating artistic spaces for the interaction of artists with visitors to exhibitions in the Irkutsk province at the turn of the 19th - 20th centuries.

Objectives: to identify materials about the activities of N. I. Verkhoturov, within the framework of which the process of coordinating the work of the creative community is described; explore artistic events aimed at disseminating knowledge about Russian art; analyze archival materials in the context of their influence on the attitude of N. I. Verkhoturov in the construction of pedagogical and creative activities, cooperation with artists and collectors.

Methodology. The work is based on an integrated approach. The principles of historicism, objectivity, and scientific character are taken into account; problem-chronological and historical-genetic methods are used.

Results. As part of the work in the archives of the Irkutsk region, materials were identified that describe the activities of N. I. Verkhoturov at the turn of the 19th - 20th centuries in creating educational institutions and organizing exhibition pavilions. Considering stories related to the master’s participation in events, one can be convinced of a change in the public’s attitude towards artists, museums, and art collections.

Conclusions. N.I. Verkhoturov participated in the creation of a drawing school, the work of educational institutions and public and scientific organizations. As a result of interaction with artists and collectors, centers of artistic life appeared in the Irkutsk province. Studying publications and materials on the history of art and the urban environment, the artist showed interest in creating educational institutions, workshops, and maintaining the work of museums and art galleries.
Challenging (appealing) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the process of state registration of a legal entity
Authors: Gabov A. V.
Published: October 2024

Relevance. A legal entity is a popular legal tool for citizens of the Russian Federation to implement their economic and other interests, as evidenced by the statistical data of the Federal Tax Service of Russia in terms of state registration of legal entities. The scale of interaction between applicants and authorized bodies, as well as persons (organizations) involved in the state registration process, the current (far from optimal) state of legislation on state registration, which creates a favorable basis for the emergence of conflicts and disputes, suggests the need to develop effective forms and means of protecting the rights and legally protected interests of applicants, which, unfortunately, does not exist yet.

The purpose of the article is to identify key problems and trends in the development of legislation in terms of appealing (challenging) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the process of state registration of a legal entity.

Objectives of the study: to analyze the development of legislation in terms of appealing (contesting) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the process of state registration of a legal entity; to identify the directions of such development, to understand the reasons for their formation; to identify the main problems and formulate ways to overcome them.

Methodology. The article is written on the basis of traditional methods for legal research; the study is based on a systems analysis.

Results. It has been established that the existing regulations were formed to a greater extent "spontaneously", in the absence of a special political and legal basis; inconsistency in the provisions of the main regulatory documents has been revealed; problems arising with pre-trial appeal of decisions (actions / inaction) of authorized bodies, actions of the MFC and its employees have been identified; problems with appealing / challenging the actions / inaction of notaries are indicated.

Conclusion. The study shows the need for a systemic reform of the rules governing issues of appealing (challenging) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the state registration process; directions for appropriate changes are proposed.
Is it possible to raise the question of the responsibility of the court?
Authors: Filippov P. М.
Published: October 2024

Relevance. Responsibility of the court for unlawful decisions has always been a matter of key concern. Since the times of Roman law which established the responsibility of judges for negligent performance of their duties to the parties, this issue with its diversified constituents has demanded to be thought over. The author reasons upon the need to establish social responsibility of judges, as well as the need to consolidate the principle of good faith in relation to their activities in the consideration and resolution of disputes.

The purpose of the research is to establish the meaning and content of the court responsibility in the framework of civil proceedings.

The research objectives are to determine social prerequisites needed to determine the responsibility of courts; to identify the importance of judges’ fair practices in determining their responsibility; and to critically comprehend the axiom "Jura novit curia" in the context of the topic under study.

Methodology. The research is based on the universal dialectical method of scientific cognition with applying analysis, deduction, description, generalization and formal legal methods.

The research resulted in the developed author's vision of the responsibility of courts. The author declares that the existence of social responsibility makes any person liable, so a judge must first of all foresee adverse consequences of his/her behavior. As the issue of good faith in terms of the judge’s conduct is not declared in procedural codes, the matter of the indisputable authority of the judicial system remains unresolved.

Conclusion. The paper frames the author's conclusion generated by many years of research about the need for a radical transformation of the institution of responsibility of courts for unlawful decisions beyond the framework of procedural appeal that is established by law.
Civil law means of implementing state policy in the field of culture
Authors: Mokhov A. A.
Published: October 2024

Relevance. The combination of external and internal threats in the field of mental (socio-cultural) security requires urgent measures in terms of correcting the state's cultural policy. Modern strategic planning documents in one way or another affect the ongoing cultural policy, identify its defects. In this regard, proposals are increasingly being made to prepare and adopt a Federal law "On Culture" that is adequate to modern geopolitical and socio-cultural realities. Ensuring mental security, preserving and strengthening traditional Russian spiritual and moral values, along with public measures, also require increased attention to civil law means of implementing state policy in the field of culture.

The purpose is to develop theoretical recommendations for improving legislation governing the organization and holding of cultural, entertainment and other cultural events.

Objectives: to establish the influence of civil law means aimed at ensuring state policy in the field of culture; to determine an approximate catalog, a list of means that can be used by the legislator in the development and adoption of the Federal Law "On Culture".

Methodology. In the process of working on the study, the dialectical-materialistic method, the systematic method, the method of analysis and synthesis, formal legal, as well as comparative legal methods were used.

Results of the study are reflected in the formulated proposals aimed at improving the legislation on culture by expanding the possible range of civil law tools that ensure a coordinated state policy in the field of culture.

Conclusion. In the course of the study, a justification was presented for the need to introduce into the legislation on culture and the practice of organizing an appropriate type of activity, holding cultural and entertainment events and similar events such civil legal means as: contracts, corporate and ethical acts, as well as starting points on civil liability.
Legal regulation of intellectual property protection for artificial neural networks
Authors: Ogarok M. A.
Published: October 2024

Relevance. Fundamental differences in the processes of development and maintenance of artificial neural networks from the algorithmic approach determine the relevance of the development of the existing scientific and methodological platform for solving technological and regulatory issues in the field of software development and legal protection of intellectual property of artificial intelligence systems.

The purpose of the study is to formulate scientifically based conclusions that determine the directions for solving the scientific problem of legal protection of intellectual property on artificial neural networks.

Objectives: to formulate a list of scientific tasks necessary for solving the scientific problem of legal protection of intellectual property rights to artificial neural networks; to develop proposals for improving the regulatory framework for registering intellectual property rights to artificial neural networks.

Methodology. The methodological basis of scientific research was the dialectical method of understanding the phenomena and processes of the surrounding reality.

Results. The obtained results of the study provide the opportunity to improve the regulatory framework establishing the basic principles of legal relations arising during the registration of intellectual property rights to artificial neural networks.

Conclusion. The solution to the problem of legal protection of intellectual property on artificial neural networks should be based on the improvement of the existing regulatory framework for the registration of intellectual property rights, as well as regulatory acts that determine the rules for registering and securing intellectual property rights to arrays of training sample data and (or) arrays of trained models of artificial neural networks, as well as to the topology of integrated circuits of neuromorphic processors.