bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospective Evaluation of the Efficacy of Electrophysiological Appropriate Techniques for Nocturia Following Radical Prostatectomy
Authors: Yang Mei , Wang Xiaomei , Huang Chenyu , Gao Feng , He Liping , Huang Yasheng , Zhu Jingyu , Yu Qiqi
Published: October 2024

This study retrospectively examines the effectiveness of low-frequency electrical stimulation for addressing nocturia in patients experiencing urinary incontinence after undergoing radical prostatectomy. We reviewed the outcomes of 32 patients who had undergone radical prostatectomy and subsequently experienced urinary incontinence. These patients were divided into the control group ( n = 16) who received pelvic floor muscle training and the treatment group ( n = 16) who underwent electrophysiological appropriate technique treatment in conjunction with pelvic floor muscle training. We assessed changes in nocturnal voided volume, polyuria index, and nocturia-related quality of life at three different time points: before treatment, after 2 weeks, and at the 3-month follow-up. After 3-month follow-up, both groups exhibit reductions in nocturnal voided volume, and polyuria index compared with baseline and the 2-week mark ( p < .05). Treatment group outperformed the control group ( p < .05). The quality of life in the treatment group remained consistently high, while the control group did not show a statistically significant difference from baseline ( p > .05). The total effective rate was significantly higher in the treatment group (93.75%) than in the control group (75.00%, p = .044). This retrospective analysis suggests that electrophysiological appropriate technique treatment effectively mitigates nocturnal, leading to improved quality of life in patients with urinary incontinence following radical prostatectomy in the near term.
Reliability analysis and optimal replacement for a k-out-of-n system with various components subject to shocks
Authors: Kelkinnama Maryam , Lorvand Hamed
Published: October 2024

Consider a k-out-of- n system consisting of L types of components, L=1,2,…,n such that the number of components of the l th type is nl, l=1,2,…,L . Let this system is exposed to external shocks, and each entered shock may fail some components of the system. The system fails when at least n-k+1 components fail. In this paper, we study the reliability of this system under a shock model. In addition to reliability analysis, we investigate a preventive maintenance policy for this system to reduce abrupt failures. Numerical examples are also provided to illustrate theoretical achievements.
Depicting truth and transition at national memorial museums in Chile and Peru
Authors: Feldman Joseph P , Del Pino Huamán Ponciano
Published: October 2024

Comparative analysis of Peru’s Place of Memory, Tolerance, and Social Inclusion and Chile’s Museum of Memory and Human Rights reveals different perspectives on how to represent past truth commissions and processes of transitioning from violence in national memorial museums. Chile’s Museum of Memory and Human Rights displays a foundational truth about state violence established through the work of the country’s truth commissions. Peru’s Place of Memory, Tolerance, and Social Inclusion was conceived as a space for presenting locally situated experiences of the country’s internal war; it is also characterized by subtle efforts to distance the museum from the narrative of the Peruvian Truth and Reconciliation Commission. Owing in part to such departures, Peru’s Place of Memory, Tolerance, and Social Inclusion offers material for questioning the country’s post-transition present that has generally been absent in the human rights-focused exhibition of the Museum of Memory and Human Rights. An assessment of these contrasts, evident in the museums’ institutional histories and permanent exhibitions, potentially unsettles assumptions about the role of official memorialization in the aftermath of truth commissions.
COLODETECT 1: comparative evaluation of endocuff with computer-aided detection versus computer-aided detection alone versus standard colonoscopy for enhancing adenoma detection rates during screening colonoscopy—a pilot study
Authors: Caillo Ludovic , Delliot Clément , Chevallier Thierry , Bourgaux Jean-Francois , Prost Ardavan , Brunaud-Gagniard Bénédicte , Phoutthasang Valérie , Clerc Clémentine , Borderie Thomas , Daniel Jules , Pouderoux Philippe , Debourdeau Antoine
Published: October 2024

Background:

Independent use of artificial intelligence with computer-aided detection (CADe) and Endocuff Vision (ECV) has demonstrated enhanced adenoma detection rates (ADRs).

Objective:

Our pilot study aimed to define the necessary participant number for future randomized controlled trials (RCTs) by comparing the ADR of combined CADe + ECV against CADe alone and standard colonoscopy.

Design:

This single-center pilot study retrospectively analyzed a prospectively maintained database, where patients underwent screening colonoscopies sequentially by standard method, CADe alone, and then CADe + ECV.

Method:

The allocation of the technique depended on the study period. Patients were randomly selected from the cohort to form three groups of 30 patients, with stratification based on factors influencing the ADR. The primary endpoint was the ADR.

Results:

From April to June 2021, 244 patients underwent screening colonoscopy. 198 were eligible, and after randomization, 90 patients were included across three groups (colonoscopy n = 30, CADe n = 30, CADe + ECV = 30). The ADR was higher in the CADe + ECV group compared to the CADe and colonoscopy groups: 60% versus 40%, and 30%, respectively ( p = 0.03). The number of polyps ⩽3 mm detected was greater in the CADe + ECV group ( n = 23) versus CADe ( n = 7) and colonoscopy ( n = 12) groups, respectively ( p = 0.03). CADe + ECV identified more polyps in the cecum/right colon ( n = 26) compared to CADe ( n = 18) and colonoscopy ( n = 12) groups ( p = 0.04), and in the left colon/sigmoid ( n = 14) compared to CADe ( n = 5) and colonoscopy ( n = 2) ( p = 0.02).

Conclusion:

These findings underscore the synergic potential of combining CADe with ECV to enhance ADR and enable us to perform sample size calculations for future RCTs.

Registration:

Clinical Trials number: NCT05080088. Registration 06/06/2021.
An overview of risk assessment and monitoring of malignant transformation in cirrhotic nodules
Authors: Xiao Zhun , Yang Fangming , Liu Zheng , Chen Xinju , Ma Suping , Li Heng
Published: October 2024

Cirrhotic liver nodules can progress to hepatocellular carcinoma (HCC) through a multi-step carcinogenesis model, with dysplastic nodules being particularly high risk. Currently, monitoring the progression of non-HCC cirrhotic nodules is primarily through dynamic observation, but there is a lack of sensitive, efficient, and convenient methods. Dynamic monitoring and risk evaluation of malignant transformation are essential for timely treatment and improved patient survival rates. Routine liver biopsies are impractical for monitoring, and imaging techniques like ultrasound, computed tomography, and magnetic resonance imaging are not suitable for all patients or for accurately assessing subcentimeter nodules. Identifying serum biomarkers with high sensitivity, specificity, and stability, and developing a multi-index evaluation model, may provide a more convenient and efficient approach to monitoring pathological changes in cirrhotic nodules.
Bridging the Atlantic: The case of EU–US parliamentary diplomacy
Authors: Vandeputte Samuel , Hecke Steven Van
Published: October 2024

With the rise of non-executive forms of diplomacy, political scientists have increasingly focused on the role of parliaments as diplomatic actors. This article aims to deepen the study of European parliamentary diplomacy through an extensive case study of transatlantic parliamentary diplomacy (TPD) between the European Parliament and the US Congress during the Obama and Trump administrations (2009–21). It is hypothesised that the decrease in EU–US political alignment under the Trump administration resulted in a corresponding decrease in both the salience and positivity of TPD. Counter-intuitively, the data shows that the decrease in political alignment correlated with a higher quantity of TPD. However, a content analysis of the joint reports of the Transatlantic Legislators’ Dialogue indicates that the attitude of this TPD is found to have become increasingly negative.
Use of an injection of aripiprazole given once every 2 months (Abilify Asimtufii®) in people with bipolar I disorder: a Plain Language Summary of Publication
Authors: McIntyre Roger S. , Such Pedro , Yildirim Murat , Madera-McDonough Jessica , Jin Na , Watkin Suzanne , Zhang Zhen , Larsen Frank , Harlin Matthew
Published: October 2024

The purpose of this summary is to explain key findings from a study that included people with bipolar I disorder, as described in two separate articles (see the ‘Further Information’ section for more details).

The study compared a new formulation of aripiprazole, given as an injection once every 2 months, with a once‑monthly injection of aripiprazole.
Researching Decolonization: Exploring the Applicability of the Concept of Decolonization to Student Activism in Ghana
Authors: Anderson Eugenia Ama Breba
Published: October 2024

This article provides a comprehensive overview of the role university students played in the decolonization discourse in Ghana. It analyses whether or not the concept of decolonization can be used to investigate the resistance of student movements through their activism. The consciousness of student movements such as the National Union of Ghana Students (NUGS) of the continuous existence of forms of colonialism despite nominal independence can be seen in student struggles for socio-economic and political justice especially struggles against neocolonialism and neoliberalism from the 1960s to the early 1990s. It investigates the continuities and discontinuities of different historical conjunctures of student movements and how these fed into the wider debates on decolonization. Using a qualitative multidisciplinary approach and relying chiefly on primary sources, open-ended interviews, newspapers and archival data, this paper analyses the connection between student political activism and the concept of decolonization in Africa. The article situates student actions within decolonisation discourses in Africa by analysing student efforts to ensure the total liberation of all African states, oppose neocolonialism, and contribute to Africa’s development.
Personality Traits, Emotional Regulation, and Happiness in Nursing Students: A Cross-Sectional Study
Authors: Shdaifat Emad , Alshowkan Amira , Alnemer Ali , Aljaafari Amani , Alsiddiq Amjad , Aljilwah Balqees , Alasfour Faris , AlYousuf Hussain , Alhamdan Wejdan , alnassar Zahrah
Published: October 2024

This cross-sectional study explored the relationship between emotional regulation, the Big Five personality traits, and happiness among 411 nursing students in Saudi Arabia, with an average age of 19.6. The Oxford Happiness Inventory, Big Five Personality Test, and Emotional Regulation Inventory were used as research instruments through selfadministered questionnaires. The findings revealed that nursing students had a moderate level of happiness (mean = 3.5), with students in their third year being happier than those in their first year. The most expressed personality traits among the students were agreeableness (79%) and conscientiousness (69%). Furthermore, the study discovered that cognitive reappraisal was higher among single students and those aged 19 or younger. Finally, the study identified extraversion, agreeableness, conscientiousness, neuroticism, and cognitive reappraisal as predictors of happiness level (adjusted R 2 = 57%). The study suggests that improving emotional regulation could enhance the happiness and well-being of nursing students.
Where Less Is More? The Effect of White Space and Product Image Dynamism on Consumer Attitudes Toward Advertisement
Authors: Liu Ping , Li Shouwei
Published: October 2024

The current study explores the role of white space within advertisements on consumers’ perceptions and the downstream consequences regarding their attitude toward the advertisement. We propose that advertisements with low (vs. high) white space on an advertisement enhances consumers’ perceived confinement about the advertisement (Study 1). Further, advertisements including high (vs. low) white space should increase consumers’ positive attitudes about the advertisement in response to the product image dynamism which is higher, while this is not the case for product image dynamism which is lower (Study 2). Two studies provide support for these propositions. This research not only helps to understand the different interpretations of white space, but also complements the literature on product image dynamism and advertising effectiveness.
Trans-Oral Protrusion of the Distal End of a Ventriculoperitoneal Shunt: A Case Report of an Unusual Complication
Authors: Nnang Joseph Y. B. , Takoutsing Berjo , Akob Lisa , Yada Gilbert , Endalle Geneviève , Njoya Mohammed , Owoundi Yvanah , Dongmo Astel , Berinyuy Mercy , Njineck Wunde , Semougnal Mustafa , Still Megan E. H. , Esene Ignatius
Published: October 2024

Ventriculoperitoneal shunting (VPS) is the surgical technique of choice to manage pediatric hydrocephalus. Despite having good results, it is prone to complications, some of which are rare. This is the case report of a 2-year-old male, with an uncomplicated VPS done at 6 months of age, presenting with vomiting, irritability, anorexia, and drooling. There was an oral protrusion of a tube dripping clear fluid. Imaging studies demonstrated evidence of gastric perforation with a cephalic migration and transoral protrusion of the distal end of the shunt tubing. A gastroplasty, and immediate revision of the distal shunt were done free of any complications. This case report underlines the importance of recognizing and managing trans-oral protrusion of the distal end of VPS system in a timely manner, and raises awareness of this uncommon complication and its potential influence on patient health and survival, given ventriculitis’ high lethality.
Influence of irradiation wavelength during laser-assisted doping of 4H-silicon carbide in liquid phase
Authors: Choutapalli Sree Harsha , H G Prashantha Kumar , Nakamura Daisuke , Jayaganthan R. , Vasa Nilesh J.
Published: October 2024

Laser-assisted doping of silicon carbide (SiC) substrates is challenging due to the low diffusion coefficient of dopant atoms and the chemically inert nature of SiC. Single crystal intrinsic 4H-SiC substrate is irradiated with neodymium-doped yttrium aluminium garnet (Nd3+):YAG laser with wavelengths of 1064, 355 and 266 nm, and krypton fluoride (KrF) excimer laser with the wavelength of 248 nm under liquid phase dopant sources. Different liquid solutions were used as dopant sources for aluminium (Al) and phosphorus (P). SiC was transparent to 1064 and 355 nm due to low absorption coefficients, while 266 and 248 nm showed better coupling due to higher absorption coefficients and led to the diffusion of atoms. The electrical resistance of the substrates was measured to be lower than 1000 kΩ after diffusion. Dispersive X-ray spectroscopy (EDS) studies showed that both laser wavelengths of 248 nm and 266 nm resulted in doping of Al and P, with the surface concentrations ranging from 0.5 to 1.5 at.% and from 0.24 to 0.6 at.%, respectively. Two-dimensional thermo-temporal simulation of the laser pulse interaction in the liquid phase revealed that unlike in air, during irradiation with 266 nm laser under liquid, the surface temperature of the substrate was slightly lower. However, the subsurface temperature increased along the depth by a few microns. Similarly, simulation studies with longer pulse irradiation also show that high temperature was maintained for a longer time, indicating improved dopant diffusion into the 4H-SiC substrate.
Ostial LCx: Achilles Heel of Left Main Bifurcation Angioplasty and How We Evolved in Its Management
Authors: Sharma Richa
Published: October 2024

In-stent restenosis (ISR) within bifurcation lesions of the left main (LM) coronary artery (LMCA) is challenging due to its complex anatomy and critical function. This case series highlights 3 patients with LM bifurcation ISR (Medina 1,1,1) post-index intervention using different stent strategies as follows:

Case 1

A 58-year-old male developed distal LM bifurcation stenosis after ostial left anterior descending artery (LAD) stenting. Mini-culotte bifurcation angioplasty effectively managed this.

Case 2

A 62-year-old male presented with neo-atherosclerosis-induced distal LM bifurcation ISR post-provisional LM-left anterior descending artery (LAD) stenting. A single-stent crossover with a drug-coated balloon in a large side branch achieved optimal flow restoration.

Case 3

A chronic total occlusion in the right coronary artery and distal LM bifurcation ISR due to stent overhang into LMCA in a 72-year-old male was resolved with a string culotte technique. These cases underscore ISR management strategies tailored to patient-specific anatomy and clinical needs, advocating advanced imaging techniques like intravascular ultrasound and optical coherence tomography for procedural precision and safety.
Safety of an Accelerated Ferric Gluconate Inpatient Infusion Regimen
Authors: Gray Erica , Parrott Tate , McCluggage Lauren
Published: October 2024

Background:

Inpatient use of intravenous iron has been increasing. Ferric gluconate is traditionally given once daily. Twice-daily dosing provides faster iron repletion, but there are limited data to support the safety of twice-daily dosing.

Objective:

The aim of this study was to investigate the safety of twice-daily dosing for ferric gluconate compared with daily dosing.

Methods:

This was an institutional review board-approved retrospective observational study of hospitalized adult patients who received intravenous ferric gluconate 250 mg daily or twice daily between January 1 and April 3, 2022. The primary composite safety outcome included hypotension, infusion reaction, rapid response alert, or escalation in level of care. Secondary outcomes included total amount of iron received, hospital length of stay, and changes in laboratory values.

Results:

A total of 126 patients were included in this study, with 63 patients in each group. The primary outcome occurred in 29 patients (46%) in the twice-daily group compared with 36 patients (57.1%) in the daily group (relative risk = 0.81; 95% CI, 0.57-1.13; P = 0.212). Changes in iron, hemoglobin, and transferrin saturation were similar between the 2 groups. Median length of stay was statistically shorter in the twice-daily group (7.79 days) compared with the daily group (12.9 days; p = 0.006).

Conclusions:

In this retrospective single-center study of hospitalized adult patients, those who received intravenous ferric gluconate twice daily did not experience an increased rate of a composite safety outcome of hypotension, infusion reactions, or escalation in level of care compared with those with daily dosing.
Current myeloproliferative neoplasm scoring systems for clinical practice
Authors: Pasquer Hélène , Kiladjian Jean-Jacques , Benajiba Lina
Published: October 2024

BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are clonal hematologic malignancies that are caused by the proliferation of myeloid cells that harbor a JAK-STAT pathway activating driver mutation. MPN management recommendations are based on the evaluation of different risks to prevent disease evolution–associated events while preserving patients’ quality of life. Such risks can be common across all MPNs or specific to each subtype (polycythemia vera [PV], essential thrombocythemia [ET], prefibrotic myelofibrosis [MF], and primary MF). Patients with MF harbor the worse prognosis, and hematopoietic stem cell transplantation (HSCT) is the only curative treatment at the expense of a high rate of morbidity and mortality. Therefore, accurate scoring systems to estimate overall survival are crucial for the management of patients with MF and the selection for HSCT. In PV and ET, the prediction of vascular events is prioritized given their higher incidence and related morbidity and mortality. Finally, quality of life evaluation is important for all subtypes. To predict these risks and adapt MPN therapeutic strategies, clinical risk scores have been developed over the past decades and more recently have incorporated molecular risk factors for more accurate risk stratification. The large number of scoring systems available, combined with disease heterogeneity and the necessity to predict diverse outcomes, make it difficult for clinicians to choose the most appropriate score to evaluate their patients’ risk in 2024. Here, we provide an overview of MPN disease evolution–associated event incidence and conduct an exhaustive comparative review of the scoring systems currently available for each risk. Finally, we propose an algorithm for the use of these scores in clinical practice in each MPN subtype.
Unravelling alternative splicing patterns in susceptible and resistant Brassica napus lines in response to Xanthomonas campestris infection
Authors: Yang Li , Yang Lingli , Zhao Chuanji , Bai Zetao , Xie Meili , Liu Jie , Cui Xiaobo , Bouwmeester Klaas , Liu Shengyi
Published: October 2024

Background

Rapeseed (Brassica napus L.) is an important oil and industrial crop worldwide. Black rot caused by the bacterial pathogen Xanthomonas campestris pv. campestris (Xcc) is an infectious vascular disease that leads to considerable yield losses in rapeseed. Resistance improvement through genetic breeding is an effective and sustainable approach to control black rot disease in B. napus. However, the molecular mechanisms underlying Brassica-Xcc interactions are not yet fully understood, especially regarding the impact of post-transcriptional gene regulation via alternative splicing (AS).

Results

In this study, we compared the AS landscapes of a susceptible parental line and two mutagenized B. napus lines with contrasting levels of black rot resistance. Different types of AS events were identified in these B. napus lines at three time points upon Xcc infection, among which intron retention was the most common AS type. A total of 1,932 genes was found to show differential AS patterns between different B. napus lines. Multiple defense-related differential alternative splicing (DAS) hub candidates were pinpointed through an isoform-based co-expression network analysis, including genes involved in pathogen recognition, defense signalling, transcriptional regulation, and oxidation reduction.

Conclusion

This study provides new insights into the potential effects of post-transcriptional regulation on immune responses in B. napus towards Xcc attack. These findings could be beneficial for the genetic improvement of B. napus to achieve durable black rot resistance in the future.
Response to "Neglecting normalization impact in semi-synthetic RNA-seq data simulation generates artificial false positives" and "Winsorization greatly reduces false positives by popular differential expression methods when analyzing human population samples"
Authors: Ge Xinzhou , Li Yumei , Li Wei , Li Jingyi Jessica
Published: October 2024

Two correspondences raised concerns or comments about our analyses regarding exaggerated false positives found by differential expression (DE) methods. Here, we discuss the points they raise and explain why we agree or disagree with these points. We add new analysis to confirm that the Wilcoxon rank-sum test remains the most robust method compared to the other five DE methods (DESeq2, edgeR, limma-voom, dearseq, and NOISeq) in two-condition DE analyses after considering normalization and winsorization, the data preprocessing steps discussed in the two correspondences.
Antibody-Drug Conjugates in Breast Cancer: Toward a Molecular Perspective Into Clinical Practice
Authors: Paz-Manrique Roberto , Pinto Joseph A. , Gomez Moreno Henry L.
Published: October 2024

Antibody-drug conjugates (ADCs) are at the forefront of cancer therapy, combining targeted precision with potent cytotoxicity. Conceived by Paul Ehrlich in the early 1900s, the concept of a magic bullet selectively eliminating cancer cells has evolved alongside bioengineering and cancer biology advancements. ADCs consist of a monoclonal antibody, linker, and cytotoxic payload, designed to target specific antigens on tumor cells while minimizing collateral damage. Mechanistically, ADCs are internalized via endocytosis, releasing the cytotoxic payload within the lysosome, potentially affecting neighboring tumor cells. ADC development has progressed through multiple generations, each addressing limitations of its predecessors. From gemtuzumab ozogamicin to trastuzumab emtansine (T-DM1), and now to third-generation agents such as trastuzumab deruxtecan (DS-8201) and disitamab vedotin (RC48), improvements have been made in target selectivity, potency, linker stability, and reduced off-target effects. Significant success has been seen in ADCs targeting human epidermal growth factor receptor 2 and trophoblast cell-surface antigen 2 antigens, especially in patients with breast cancer, including those resistant to previous therapies. The future of ADCs includes exploring new surface antigens, bispecific antibodies, immune-activating antibodies, radiopharmaceutical-loaded ADCs, and masked ADCs for tissue-specific activation. Ongoing research aims to optimize treatment efficacy while minimizing toxicity, expanding the potential of combination therapy. ADCs represent a promising frontier in precision cancer treatment, with continued research enhancing their potential in breast cancer and beyond. This review provides a comprehensive exploration of ADCs' evolution in breast cancer therapy, offering a molecular perspective to inform clinical practice and update colleagues on this dynamic field.
Almost 40 years of studying homeobox genes in C. elegans
Authors: Kratsios Paschalis , Hobert Oliver
Published: October 2024

Homeobox genes are among the most deeply conserved families of transcription factor-encoding genes. Following their discovery in Drosophila, homeobox genes arrived on the Caenorhabditis elegans stage with a vengeance. Between 1988 and 1990, just a few years after their initial discovery in flies and vertebrates, positional cloning and sequence-based searches showed that C. elegans contains HOX cluster genes, an apparent surprise given the simplicity and non-segmented body plan of the nematode, as well as many other non-clustered homeobox genes of all major subfamilies (e.g. LIM, POU, etc.). Not quite 40 years later, we have an exceptionally deep understanding of homeodomain protein expression and function in C. elegans, revealing their prevalent role in nervous system development. In this Spotlight, we provide a historical perspective and a non-comprehensive journey through the C. elegans homeobox field and discuss open questions and future directions.
Characterization of a rapid avoidance behavior in Manduca sexta larvae in response to noxious stimuli
Authors: Kondakath Gayathri , Trimmer Barry A.
Published: October 2024

This study focuses on the nociceptive responses observed in the tobacco hornworm (Manduca sexta). While prior investigations have described the sensory neurons and muscle activation patterns associated with the ‘strike’ behavior, there remains a gap in our understanding of the alternative ‘withdrawal’ movement, wherein the animal bends its head and thorax away from the stimulus. Our results show that stimulus location determines which nocifensive behavior is elicited. Interestingly, stimulation of specific mid-body segments could result in either withdrawal or strike, indicating a decision process rather than a hard-wired circuit. The withdrawal behavior was characterized using high-speed videography and electromyography. The results show that withdrawal in M. sexta is driven by contralateral ventral muscles, followed by an increase in ipsilateral muscle activation just before the bending stops. Dorsal muscles are co-activated throughout the movement. Although both withdrawal and strike behaviors involve sequential activation of lateral muscles, these behaviors involve different muscle groups. This discovery provides a novel model system to investigate the context dependence and decision-making processes triggered by stressful or noxious stimuli.
The glycoprotein hormone receptor (LGR1) influences Malpighian tubule secretion rate in Rhodnius prolixus
Authors: Al-Dailami Areej N. , Lange Angela B. , Orchard Ian
Published: October 2024

In the hemipteran Rhodnius prolixus, successful post-prandial diuresis is accomplished through the synergistic actions of the peptidergic diuretic hormone RhoprCRF/DH and the biogenic amine 5-hydroxytryptamine (5-HT), and by an antidiuretic hormone RhoprCAPA-2 that terminates diuresis by inhibiting this synergy. Lateral neurosecretory cells (NSCs) in the mesothoracic ganglionic mass release RhoprCRF/DH, while midline NSCs release RhoprCAPA-2 during blood feeding. These NSCs co-express GPA2/GPB5, a conserved glycoprotein hormone involved in various physiological processes across bilaterians. This study investigated the influence of GPA2/GPB5 signaling on Malpighian tubule (MT) fluid secretion in R. prolixus. GPB5-like immunoreactivity in lateral and midline NSCs decreased following a blood meal, suggesting release and a role in diuresis. Downregulating the GPA2/GPB5 receptor LGR1 via RNA interference resulted in an increased basal fluid secretion rate in MTs, which was inhibited by the antidiuretic hormone RhoprCAPA-2. dsLGR1 treatment reduced the effects of RhoprCRF/DH and 5-HT on MT secretion and eliminated their synergism. RT-qPCR revealed that the expression of the diuretic and antidiuretic hormone receptors decreased in MTs of dsLGR1-injected insects, indicating that GPA2/GPB5 influences the expression of these other receptors. Downregulating LGR1 resulted in a smaller blood meal size and disrupted the normal time course of diuresis. As LGR1 is the most abundantly expressed G protein-coupled receptor gene in R. prolixus MTs, our results suggest that GPA2/GPB5 signaling has a critical role in regulating the timing and success of water retention in the unfed state, and in the complex processes associated with feeding and diuresis in R. prolixus.
Management of economic security of a higher educational institution
Authors: Yudina Tat'yana , Duhanina Elena , Vinogradova Elena , Kalinina Ol'ga , Loginova Nadezhda , Reznik Galina , Vdovina Ol'ga , Filippov Kirill , Hrustalev Boris , Fedosova Tat'yana , Tikhomirova N. , Fyedosova Tatyana , Masych Marina
Published: October 2024

The problem of economic security of a higher educational institution is becoming particularly relevant. This is explained by the increasing competition between universities, the economic instability of society, the lack of mechanisms for insuring the risks of making managerial decisions in the field of education and other factors.
The textbook pays special attention to practical mechanisms for ensuring economic security both within the university and in its interaction with the external environment.
For managers and employees of economic services of higher educational institutions, as well as for everyone who studies the problems of economic security of Russian universities.
Criminal law of the Russian Federation. The special part
Authors: Gorshkova Natal'ya , Zezyulina Tat'yana , Pichugin Sergey , Tarakanov Il'ya , Mihaylov Aleksey , Pikin Ivan , Kolosov Anton , Golovkin Roman , Prohorova Marina , Zaripov Renat , Karlov Il'ya
Published: October 2024

The textbook examines in detail the categories and institutions of a Special part of criminal law, gives a general description and a detailed analysis of the elements of crimes, examines the issues of their qualification. Prepared in accordance with the provisions of the Constitution of the Russian Federation, the Criminal Code of the Russian Federation, federal laws and by-laws, explanations of the Plenum of the Supreme Court of the Russian Federation. The material is presented in an accessible form for effective learning of the discipline.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students studying in the specialty 40.05.02 "Law enforcement", graduate students, teachers of law schools, as well as all those who are interested in the qualification of crimes.
China's fuel and energy complex and the global energy problem
Authors: Zaharov Aleksandr , Dolgov Sergey , Anikina Elizaveta , Grebennikov Igor'
Published: October 2024

The monograph outlines the main factors influencing the development of the global energy market. Attention is paid to the specifics of using energy resources to solve urgent problems of the global fuel and energy sector - minimizing the consequences of the global energy crisis, ensuring the energy security of states, responding to the challenges of climate change, the transition to decarbonization, as well as global energy management. In the context of China's fuel and energy complex, the issues of exporting China's nuclear energy technologies, China's investments in the fuel and energy complexes of the countries of the African continent and Central Asia are considered. The objectives, strategy and prospects of China's participation in Arctic projects are considered. The energy security of Russia and other countries of the world is analyzed in the context of the prospects for the development of global energy until 2060. The development of mutually beneficial trade and economic relations between Russia and China in the energy sector, in the field of trade and investment is considered.
For researchers and practitioners in the field of energy, as well as for teachers, graduate students and students of economic fields of study and specialties of universities.
Textile materials science in the context of Industry 4.0: digital counterparts of textile materials
Authors: Abramov Anton , Shustov Yuriy , Rodicheva Margarita
Published: October 2024

The monograph examines the issues of developing digital counterparts of textile materials. The given material gives an idea of new tools for predicting the state of textile materials during their use in sewing products.
It may be useful to specialists in the field of clothing design, undergraduates studying in the fields of 27.04.01 "Standardization and metrology", 29.04.02 "Technologies and design of textile products", 29.04.05 "Design of light industry products", 09.04.02 "Information systems and technologies", as well as graduate students studying in the specialty 2.6.16 "Technology of textile products production and light industry."
Microbiology
Authors: Sidorenko Oleg
Published: October 2024

The textbook presents modern data on general microbiology, a comprehensive analysis of the industrial biotechnology industry and the bioconversion of renewable resources. For the first time, agricultural waste is considered as a raw material for obtaining useful products: organic fertilizers, feed additives, medicinal preparations, energy sources, etc.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the field of training "Technology of production and processing of agricultural products".
Word and thought: one step ahead
Authors: Harchenko Vera
Published: October 2024

The monograph is devoted to non-traditional ways of thinking, which can be added to the methods already available and well-proven. The idea of combining science and art, combining the intentional and the accidental, is not new. The word is perceived as a bright, weighty tool that opens up new depths of knowledge. Heuristic, unpredictable thought patterns lurk in the original use of language. Over forty diverse forms of such combined, convergent work operating in the modern world have been considered and summarized.
It is intended for linguists and a wide range of readers interested in the possibilities of the Russian language.
Meta-economics
Authors: Grodskiy Vadimir
Published: October 2024

The monograph presents for the first time the development of Karl Marx's formation model and its development as a necessary independent section of economics — "Meta-economics". The essence and historical causes of the crisis in the modern economy are shown. The overdue reconstruction of the most important imperfections of micro- and macroeconomics has been carried out. The author's proposals are aimed at improving the logical coherence of economic theory and bringing it closer to solving practical problems.
It is addressed to researchers, teachers and students of the Master's degree in economics.
Currency control
Authors: Sitnik Aleksandr , Arzumanova Lana , Artemov Nikolay , Guznov Aleksey
Published: October 2024

The textbook has been prepared in accordance with the federal state educational standard of higher education in the field of Law (qualification (degree) "Master"). In the theoretical part, based on the analysis of currency legislation, acts of currency regulation bodies, the practice of their application and the doctrine of financial law, the concepts of currency regulation and currency control, the system of currency control, types of currency restrictions, the legal status of participants in currency transactions, bodies and agents of currency control, types of liability for violation of currency legislation are revealed. Special attention is paid to the analysis of the currency legislation of the member states of the Eurasian Economic Union. The practical part contains tasks and tests. In addition, the textbook is provided with diagrams that clearly illustrate the main issues considered in the theoretical part.
For undergraduates, postgraduates, teachers of law and economics universities, practicing lawyers and entrepreneurs.
NAVIGATING THE REGULATORY LANDSCAPE OF VOLUNTARY SUSTAINABILITY STANDARDS IN INTERNATIONAL FOOD TRADE: A MULTILATERAL INTERPLAY - DOI: 10.12818/P.0304-2340.2024v85p171
Authors: Fu Jiangyuan
Published: October 2024

Voluntary sustainability standards (VSSs) are non-mandatory criteria designed to foster sustainable practices throughout the global supply chain. These standards are particularly prevalent in the agri-food sector, where they aim to support wider public policy objectives such as sustainable food production, animal welfare, healthy lifestyle, and labour conditions. Significant challenges arises from the fact that VSSs, despite their voluntary nature, they often impose mandatory effect in the global supply chain. They also often lack easily-identifiable features of the product themselves. These creates systematic problems for the global food trade system, where conventional regulation address governmental measures on goods with specific inherent characteristics that can be clearly identified in the final product. This article explored the interrelationship among private VSSs, national regulations and international treaties within the agri-food industry. It highlights ambiguity surrounding the regulatory framework for VSSs under the WTO law, noting the absence of a consensus on how relevant provisions should be interpreted. Despite the diversity among various VSSs, VSSs, this article argues for the potential for harmonization and equivalence among VSSs. By aligning various VSSs and with technical regulations, it is possible to strike a balance between trade liberalization and promotion of sustainable practices.
Code and Data Repository for On Discrete Subproblems in Integer Optimal Control with Total Variation Regularization in Two Dimensions
Authors: Manns Paul , Severitt Marvin
Published: October 2024

The goal of this repository to be able to trace and reproduce the results and plots in the referenced article. For the results in this article, we used the general purpose integer programming solver Gurobi version 10.0.0. In addition, you need to have the python packages pandas, numpy, scipy, and pybind11 installed to be able to build the code for computing the weights of the cutting planes from 5.1.1.
Bayesian Ensembles of Exponentially Smoothed Life-Cycle Forecasts
Authors: Guo Xiaojia , Lichtendahl Kenneth C. , Grushka-Cockayne Yael
Published: October 2024

Problem definition: We study the problem of forecasting an entire demand distribution for a new product before and after its launch. Firms need accurate distributional forecasts of demand to make operational decisions about capacity, inventory, and marketing expenditures. We introduce a unified, robust, and interpretable approach to producing these pre- and postlaunch distributional forecasts. Methodology/results: Our approach is inspired by Bayesian model averaging. Each candidate model in our ensemble is a life-cycle model fitted to the completed life cycle of a comparable product. A prelaunch forecast is an ensemble with equal weights on the candidate models’ forecasts, whereas a postlaunch forecast is an ensemble with weights that evolve according to Bayesian updating. Our approach is part frequentist and part Bayesian, resulting in a novel approach tailored to the demand forecasting challenge. We also introduce a new type of life-cycle or product diffusion model with states that can be updated using exponential smoothing. The trend in this model follows the density of an exponentially tilted Gompertz random variable. For postlaunch forecasting, this model is attractive because it can adapt itself to the most recent changes in a product’s life cycle. We provide closed-form distributional forecasts from our model. In two empirical studies, we show that when the ensemble’s candidate models are all in our new type of exponential smoothing model, this version of the ensemble outperforms several leading approaches in both point and quantile forecasting. Managerial implications: In a data-driven operations environment, our model can produce accurate forecasts frequently and at scale. When quantile forecasts are needed, our model has the potential to provide meaningful economic benefits. In addition, our model’s interpretability should be attractive to managers who already use exponential smoothing and ensemble methods for other forecasting purposes.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0359 .
TB or Not TB, That is the Question?
Authors: McAuliffe Ellen , Renton Bryan
Published: October 2024

A 26-year-old female presented with a 3-month history of dry cough, unintentional weight loss, night sweats and fatigue. Her background history was significant for ulcerative colitis, managed with Adalimumab for almost 2 years. Clinical examination was unremarkable, apart from some mild pallor. Abnormal chest x-ray findings prompted a computerised tomography (CT) thorax which demonstrated multifocal peri-bronchial consolidation. The differential diagnosis was multifocal organising pneumonia and tuberculosis (TB). Extensive investigations, including invasive bronchial imaging and biopsy, ultimately ruled out TB. This paper reports a case of Adalimumab-induced organising pneumonia and discusses its clinical implications.
Chronic Lymphocytic Thyroiditis is a Protective Factor for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Propensity Score Matching Analysis
Authors: Yu Jian , Li Xiaoyang , He Zhijian , He Jie , Rao Shangrui
Published: October 2024

Aims/Background The connection between lymph node (LN) metastases in papillary thyroid carcinoma (PTC) and chronic lymphocytic thyroiditis (CLT) has been examined in a number of prior investigations. However, there is ongoing debate over the effect of CLT on LN metastasis in PTC. In order to explain the relationship between CLT and LN metastasis more convincingly, we aimed to retrospectively review clinical data to investigate the correlation between CLT and LN metastasis in PTC using propensity score matching (PSM).

Methods Data on PTC patients at Wenzhou Central Hospital were collected retrospectively between 1 January 2018, and 31 March 2022. The patients were split into two groups based on whether they had CLT or not. The clinicopathological characteristics of the two groups were compared using a PSM analysis. The relationship between CLT and LN metastases was analyzed using logistic regression analysis.

Results Among the 773 PTC patients collected and examined, 213 showed simultaneous CLT. Prior to PSM, patients with CLT displayed a significantly lower incidence of LN metastasis (34.3% VS 44.8%, p = 0.008), a lower metastatic LN ratio (0 (0, 0.17) VS 0 (0, 0.38), p = 0.011), and a greater number of LNs dissected (7 (5, 11) VS 5 (3, 7), p < 0.001). These differences persisted after the PSM of 208 pairs. After PSM, patients with CLT displayed a significantly lower incidence of LN metastasis (35.0% VS 44.7%, p = 0.045), a lower metastatic LN ratio (0 (0, 0.17) VS 0 (0, 0.33), p = 0.038), and a higher number of dissected LNs (7 (5, 11) VS 5 (3, 7), p ≤ 0.001). Additionally, the multivariate logistic regression analysis indicated that CLT had a protective role against LN metastasis in both the matched group (odds ratio (OR), 0.62; 95% confidence interval (CI): 0.39–0.96; p = 0.032) and the unmatched group (OR, 0.63; 95% CI: 0.44–0.91; p = 0.014).

Conclusion Our data indicate that CLT may protect against LN metastases in patients with PTC. Patients having PTC with coexisting CLT have fewer LN metastases, a greater number of LNs dissected, and a lower metastatic LN ratio.
The Impact of Blood Pressure Rhythm and Perioperative Blood Pressure Variability on Short-Term Prognosis in Patients with Type A Aortic Dissection
Authors: Wu Yihui , Zhou Hao , Li Weifeng , Chen Suli , Wang Huajun , He Binbin , Jiang Huiqin , Wang Wenpeng
Published: October 2024

Aims/Background Previous studies have indicated a strong correlation between disturbances in blood pressure (BP) circadian rhythm and major cardiovascular adverse events. Similarly, blood pressure variability (BPV) has been closely linked to cerebral small vessel disease and leukoaraiosis. This study aims to investigate the relationship between BP rhythm and BPV with the short-term prognosis of patients with Type A aortic dissection, offering insights for targeted perioperative nursing interventions and improving patient outcomes.

Methods This retrospective study included patients undergoing surgical treatment for Type A aortic dissection at Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) from June 2022 to March 2024. The study followed patients from the completion of surgery to 30 days postoperatively, with all-cause mortality within 30 days as the endpoint representing poor short-term prognosis. Clinical data were compared along with: types of BP rhythm; BPV parameters including the mean 24-hour systolic BP (24hSBP), 24-hour diastolic BP (24hDBP), and pulse pressure; and the coefficient of variability (CV) for 24hSBP, 24hDBP, and pulse pressure. Multivariate logistic regression analysis was utilized to identify risk factors for poor short-term outcomes in these patients, and receiver operating characteristic (ROC) curves were plotted to assess the predictive value of BP rhythm types and BPV indicators.

Results The study ultimately included 115 participants, with 31 deaths occurring within 30 days post-surgery, resulting in a postoperative mortality rate of 26.96%. The multivariate logistic regression analysis revealed that white blood cell count, neutrophil count, non-dipping BP rhythm, pulse pressure, and the CV for 24hSBP, 24hDBP, and pulse pressure, were significant risk factors for poor short-term prognosis (p < 0.05). The ROC curve analysis demonstrated that non-dipping BP rhythm, pulse pressure, 24hSBP-CV, 24hDBP-CV, and pulse pressure-CV had areas under the curve (AUC) of 0.685, 0.749, 0.751, 0.773, and 0.763, respectively. The combination of these indicators yielded the highest AUC at 0.918.

Conclusion A combination of BP rhythm and BPV indicators provides significant predictive value for poor short-term outcomes in patients with Type A aortic dissection. Clinicians and nursing staff can use these features to formulate targeted preventive measures.