bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Variation among Pharmacogenes in the Sardinian Population
Authors: Idda Maria Laura , Zoledziewska Magdalena , Urru Silvana Anna Maria , McInnes Gregory , Bilotta Alice , Nuvoli Viola , Lodde Valeria , Orrù Sandro , Schlessinger David , Cucca Francesco , Floris Matteo
Published: September 2022

Pharmacogenetics (PGx) aims to identify the genetic factors that determine inter-individual differences in response to drug treatment maximizing efficacy while decreasing the risk of adverse events. Estimating the prevalence of PGx variants involved in drug response, is a critical preparatory step for large-scale implementation of a personalized medicine program in a target population. Here, we profiled pharmacogenetic variation in fourteen clinically relevant genes in a representative sample set of 1577 unrelated sequenced Sardinians, an ancient island population that accounts for genetic variation in Europe as a whole, and, at the same time is enriched in genetic variants that are very rare elsewhere. To this end, we used PGxPOP, a PGx allele caller based on the guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), to identify the main phenotypes associated with the PGx alleles most represented in Sardinians. We estimated that 99.43% of Sardinian individuals might potentially respond atypically to at least one drug, that on average each individual is expected to have an abnormal response to about 17 drugs, and that for 27 drugs the fraction of the population at risk of atypical responses to therapy is more than 40%. Finally, we identified 174 pharmacogenetic variants for which the minor allele frequency was at least 10% higher among Sardinians as compared to other European populations, a fact that may contribute to substantial interpopulation variability in drug response phenotypes. This study provides baseline information for further large-scale pharmacogenomic investigations in the Sardinian population and underlines the importance of PGx characterization of diverse European populations, such as Sardinians.
PET Probes for Preclinical Imaging of GRPR-Positive Prostate Cancer: Comparative Preclinical Study of [68Ga]Ga-NODAGA-AMBA and [44Sc]Sc-NODAGA-AMBA
Authors: Kálmán-Szabó Ibolya , Szabó Judit P. , Arató Viktória , Dénes Noémi , Opposits Gábor , Jószai István , Kertész István , Képes Zita , Fekete Anikó , Szikra Dezső , Hajdu István , Trencsényi György
Published: September 2022

Gastrin-releasing peptide receptors (GRPR) are overexpressed in prostate cancer (PCa). Since bombesin analogue aminobenzoic-acid (AMBA) binds to GRPR with high affinity, scandium-44 conjugated AMBA is a promising radiotracer in the PET diagnostics of GRPR positive tumors. Herein, the GRPR specificity of the newly synthetized [44Sc]Sc-NODAGA-AMBA was investigated in vitro and in vivo applying PCa PC-3 xenograft. After the in-vitro assessment of receptor binding, PC-3 tumor-bearing mice were injected with [44Sc]Sc/[68Ga]Ga-NODAGA-AMBA (in blocking studies with bombesin) and in-vivo PET examinations were performed to determine the radiotracer uptake in standardized uptake values (SUV). 44Sc/68Ga-labelled NODAGA-AMBA was produced with high molar activity (approx. 20 GBq/µmoL) and excellent radiochemical purity. The in-vitro accumulation of [44Sc]Sc-NODAGA-AMBA in PC-3 cells was approximately 25-fold higher than that of the control HaCaT cells. Relatively higher uptake was found in vitro, ex vivo, and in vivo in the same tumor with the 44Sc-labelled probe compared to [68Ga]Ga-NODAGA-AMBA. The GRPR specificity of [44Sc]Sc-NODAGA-AMBA was confirmed by significantly (p ≤ 0.01) decreased %ID and SUV values in PC-3 tumors after bombesin pretreatment. The outstanding binding properties of the novel [44Sc]Sc-NODAGA-AMBA to GRPR outlines its potential to be a valuable radiotracer in the imaging of GRPR-positive PCa.
Biochemical Neuroadaptations in the Rat Striatal Dopaminergic System after Prolonged Exposure to Methamphetamine Self-Administration
Authors: Jayanthi Subramaniam , Ladenheim Bruce , Sullivan Patricia , McCoy Michael T. , Krasnova Irina N. , Goldstein David S. , Cadet Jean Lud
Published: September 2022

Perturbations in striatal dopamine (DA) homeostasis might underlie the behavioral and pathobiological consequences of METH use disorder in humans. To identify potential consequences of long-term METH exposure, we modeled the adverse consequence DSM criterion of substance use disorders by giving footshocks to rats that had escalated their intake of METH during a drug self-administration procedure. Next, DA D1 receptor antagonist, SCH23390 was injected. Thereafter, rats were euthanized to measure several indices of the striatal dopaminergic system. Footshocks split the METH rats into two phenotypes: (i) shock-sensitive that decreased their METH-intake and (ii) shock-resistant that continued their METH intake. SCH23390 caused substantial dose-dependent reduction of METH taking in both groups. Stopping SCH23390 caused re-emergence of compulsive METH taking in shock-resistant rats. Compulsive METH takers also exhibited greater incubation of METH seeking than non-compulsive rats during withdrawal from METH SA. Analyses of DA metabolism revealed non-significant decreases (about 35%) in DA levels in resistant and sensitive rats. However, striatal contents of the deaminated metabolites, DOPAL and DOPAC, were significantly increased in sensitive rats. VMAT2 and DAT protein levels were decreased in both phenotypes. Moreover, protein expression levels of the D1-like DA receptor, D5R, and D2-like DA receptors, D3R and D4R, were significantly decreased in the compulsive METH takers. Our results parallel findings in post-mortem striatal tissues of human METH users who develop Parkinsonism after long-term METH intake and support the use of this model to investigate potential therapeutic interventions for METH use disorder.
Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder
Authors: Szeleszczuk Łukasz , Frączkowski Dawid
Published: September 2022

Propranolol, a non-cardioselective β1,2 blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. This review focuses on the application of propranolol in the treatment of various types of anxiety and stress, with particular reference to stage fright and post-traumatic stress disorder (PTSD). Both mechanisms of action as well as comparison with other therapies are presented. As those indications for propranolol are, in most countries, considered off-label, this review aims to gather information that can be useful while making a decision about the choice of propranolol as a drug in the treatment of those mental conditions.
Temporal Expression of Myogenic Regulatory Genes in Different Chicken Breeds during Embryonic Development
Authors: Gu Shuang , Wen Chaoliang , Li Junying , Liu Honghong , Huang Qiang , Zheng Jiangxia , Sun Congjiao , Yang Ning
Published: September 2022

The basic units of skeletal muscle in all vertebrates are multinucleate myofibers, which are formed from the fusion of mononuclear myoblasts during the embryonic period. In order to understand the regulation of embryonic muscle development, we selected four chicken breeds, namely, Cornish (CN), White Plymouth Rock (WPR), White Leghorn (WL), and Beijing-You Chicken (BYC), for evaluation of their temporal expression patterns of known key regulatory genes (Myomaker, MYOD, and MSTN) during pectoral muscle (PM) and thigh muscle (TM) development. The highest expression level of Myomaker occurred from embryonic days E13 to E15 for all breeds, indicating that it was the crucial stage of myoblast fusion. Interestingly, the fast-growing CN showed the highest gene expression level of Myomaker during the crucial stage. The MYOD gene expression at D1 was much higher, implying that MYOD might have an important role after hatching. Histomorphology of PM and TM suggested that the myofibers was largely complete at E17, which was speculated to have occurred because of the expression increase in MSTN and the expression decrease in Myomaker. Our research contributes to lay a foundation for the study of myofiber development during the embryonic period in different chicken breeds.
Evaluation of the Effect of the Fibroblast Growth Factor Type 2 (FGF-2) Administration on Placental Gene Expression in a Murine Model of Preeclampsia Induced by L-NAME
Authors: Martinez-Fierro Margarita L , Garza-Veloz Idalia , Castañeda-Lopez Maria Eugenia , Wasike Dorothy , Castruita-De la Rosa Claudia , Rodriguez-Sanchez Iram Pablo , Delgado-Enciso Ivan , Flores-Mendoza Jose
Published: September 2022

The abnormal implantation of the trophoblast during the first trimester of pregnancy precedes the appearance of the clinical manifestations of preeclampsia (PE), which is a hypertensive disorder of pregnancy. In a previous study, which was carried out in a murine model of PE that was induced by NG-nitro-L-arginine methyl ester (L-NAME), we observed that the intravenous administration of fibroblast growth factor 2 (FGF2) had a hypotensive effect, improved the placental weight gain and attenuated the fetal growth restriction, and the morphological findings that were induced by L-NAME in the evaluated tissues were less severe. In this study, we aimed to determine the effect of FGF2 administration on the placental gene expression of the vascular endothelial growth factor (VEGFA), VEGF receptor 2 (VEGFR2), placental growth factor, endoglin (ENG), superoxide dismutase 1 (SOD1), catalase (CAT), thioredoxin (TXN), tumor protein P53 (P53), BCL2 apoptosis regulator, Fas cell surface death receptor (FAS), and caspase 3, in a Sprague Dawley rat PE model, which was induced by L-NAME. The gene expression was determined by a real-time polymerase chain reaction using SYBR green. Taking the vehicle or the L-NAME group as a reference, there was an under expression of placental VEGFA, VEGFR2, ENG, P53, FAS, SOD1, CAT, and TXN genes in the group of L-NAME + FGF2 (p < 0.05). The administration of FGF2 in the murine PE-like model that was induced by L-NAME reduced the effects that were generated by proteinuria and the increased BP, as well as the response of the expression of genes that participate in angiogenesis, apoptosis, and OS. These results have generated valuable information regarding the identification of molecular targets for PE and provide new insights for understanding PE pathogenesis.
Sequestration of Inflammation in Parkinson’s Disease via Stem Cell Therapy
Authors: Gordon Jonah , Lockard Gavin , Monsour Molly , Alayli Adam , Choudhary Hassan , Borlongan Cesario V.
Published: September 2022

Parkinson’s disease is the second most common neurodegenerative disease. Insidious and progressive, this disorder is secondary to the gradual loss of dopaminergic signaling and worsening neuroinflammation, affecting patients’ motor capabilities. Gold standard treatment includes exogenous dopamine therapy in the form of levodopa–carbidopa, or surgical intervention with a deep brain stimulator to the subcortical basal ganglia. Unfortunately, these therapies may ironically exacerbate the already pro-inflammatory environment. An alternative approach may involve cell-based therapies. Cell-based therapies, whether endogenous or exogenous, often have anti-inflammatory properties. Alternative strategies, such as exercise and diet modifications, also appear to play a significant role in facilitating endogenous and exogenous stem cells to induce an anti-inflammatory response, and thus are of unique interest to neuroinflammatory conditions including Parkinson’s disease. Treating patients with current gold standard therapeutics and adding adjuvant stem cell therapy, alongside the aforementioned lifestyle modifications, may ideally sequester inflammation and thus halt neurodegeneration.
Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death
Authors: Albadawy Reda , Hasanin Amany Helmy , Agwa Sara H. A. , Hamady Shaimaa , Aboul-Ela Yasmin M. , Raafat Mona Hussien , Kamar Samaa Samir , Othman Mohamed , Yahia Yahia A. , Matboli Marwa
Published: September 2022

Background: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease that urgently needs effective therapy. Rosavin, a major constituent of the Rhodiola Rosea plant of the family Crassulaceae, is believed to exhibit multiple pharmacological effects on diverse diseases. However, its effect on non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, and the underlying mechanisms are not fully illustrated. Aim: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA-6881-5P and lnc-SPARCL1-1:2) in NASH rats. Results: High sucrose high fat (HSHF) diet-induced NASH rats were treated with different concentrations of rosavin (10, 20, and 30 mg/kg/day) for the last four weeks of dietary manipulation. The data revealed that rosavin had the ability to modulate the expression of the hepatic cell death-related RNA panel through the upregulation of both (HSPD1/TNF/MMP14/ITGB1) mRNAs and their epigenetic regulators (miRNA-6881-5P and lnc-SPARCL1-1:2). Moreover, rosavin ameliorated the deterioration in both liver functions and lipid profile, and thereby improved the hepatic inflammation, fibrosis, and apoptosis, as evidenced by the decreased protein levels of IL6, TNF-α, and caspase-3 in liver sections of treated animals compared to the untreated NASH rats. Conclusion: Rosavin has demonstrated a potential ability to attenuate disease progression and inhibit hepatic cell death in the NASH animal model. The produced effect was correlated with upregulation of the hepatic cell death-related (HSPD1, TNF, MMP14, and ITGB1) mRNAs—(miRNA-6881-5P—(lnc-SPARCL1-1:2) RNA panel.
The “6B” Strategy: Build Back a Better Blood–Brain Barrier
Authors: Calvier Laurent , Alexander Anna E. , Herz Joachim
Published: September 2022

Under pathological conditions such as multiple sclerosis (MS), leukocytes infiltrate the central nervous system where they, in concert with activated microglia, promote inflammatory demyelination resulting in a broad spectrum of symptoms, including paralysis. Therefore, all current therapeutic approaches to MS target the immune system, blocking inflammation and paralysis progression, but may compromise the immune system. In this focused review, we present an underestimated compartment, the blood–brain barrier, which is compromised during MS and becomes permeable to leukocytes infiltrating the central nervous system. This barrier has the potential to offer new therapeutic strategies and is easily accessible for drugs. We highlight this paradigm using the example of the therapeutic anti-Reelin strategy we have developed. Reelin is a plasma protein that regulates the expression of adhesion markers on the endothelial surface, thus promoting the infiltration of inflammatory cells and propagating inflammation. Building Back a Better Blood–Brain Barrier (the “6B” strategy) may have advantages compared to actual immunosuppressive drugs because it restores a physiological function rather than suppressing the immune system.
The Effect of Bean Seed Treatment with Entomopathogenic Fungus Metarhizium robertsii on Soil Microarthropods (Acari, Collembola)
Authors: Novgorodova Tatiana , Vladimirova Natalia , Marchenko Irina , Sadokhina Tatyana , Tyurin Maksim , Ashmarina Lyudmila , Bakshaev Dmitry , Lednev Georgy , Danilov Viktor
Published: September 2022

The treatment of agricultural crops with entomopathogenic fungi may disturb the structure of soil microarthropod communities, which can have an adverse impact on soil fertility and, ultimately, on the yield. The effect of the treatment of broad bean (Vicia faba L.) seeds, with the entomopathogenic fungus Metarhizium robertsii, on the abundance and community structure of soil microarthropods in the rhizosphere was assessed in different phases of plant vegetation in a two-year experiment. Under the conditions of the gradually decreased abundance of M. robertsii both in the soil cenoses and in the plants during summer, no adverse effect was revealed of the bean seed treatment, with the entomopathogenic fungus, on the abundance of soil microarthropods (Acari: Mesostigmata, Prostigmata, Oribatida and Astigmata; Collembola) and the structure of their communities. Similar results were obtained in the analysis, taking into account the positive colonization of plants. Some changes in the microarthropod community structure were explained primarily by the spatial heterogeneity of the field, the hydrothermal regime, and the features of the microarthropod life cycles. The results indicate the possibility of using dressing seeds with conidial suspension for plant inoculation with entomopathogenic fungus (at least M. robertsii) as a potentially safe plant protection method for non-target soil microarthropods.
Bioconversion Potential of Agro-Industrial Byproducts by Tenebrio molitor—Long-Term Results
Authors: Bordiean Anna , Krzyżaniak Michał , Stolarski Mariusz Jerzy
Published: September 2022

The aim of this study was to compare the growth performance, feed conversion ratio (FCR), and efficiency of ingested feed (ECI) by larvae of the Tenebrio molitor beetle. The growth and development potential of the yellow mealworm was evaluated by using chicken feed (CF), rapeseed meal (RM), wheat bran (WB), and willowleaf sunflower (WS) to obtain inexpensive and various sources of feed. The results showed that the fastest growth with shorter larval development time (74.7 days) was found for insects fed a WB 100 diet. Regarding the final fresh weight of larvae, the highest values were found for larvae grown on WB diets. However, the lowest FCR (1.53 to 1.59) was found for larvae fed RM diets mixed with CF and on the control diet (CF 100). In most cases, it was found that byproduct diets mixed with CF improve the ECI of mealworms, thus contributing to an efficient bioconversion of byproducts into edible sources of nutrients. Thus, except for pure WS as a feed, these byproducts can be used to grow yellow mealworm larvae and may be added to the versatile list of substrates and feed used by small- and large-scale insect producers.
A Metric for Questions and Discussions Identifying Concerns in Software Reviews
Authors: Wakimoto Michiyo , Morisaki Shuji
Published: September 2022

Previous studies reported that reviewers ask questions and engage in discussions during software reviews and that the concerns identified by the questions and discussions help detect defects. Although such concerns about potential defects lead to finding defects, review metrics such as the number of defects detected do not always reflect the questions and discussions because concerns which are not applicable to the review material are excluded from the number of defects. This paper proposes a metric, the number of questions and discussions, which identifies concerns in reviews. First, we defined an effective question, which identifies concerns. Then, we defined detailed review processes (identifying, sharing, and recording processes), which capture how concerns identified by effective questions are shared and defects are documented. We conducted a case study with 25 projects in industry to investigate the impact of the number of effective questions, which identified concerns on the number of detected defects in subsequent testing. The results of a multiple regression analysis show that the number of effective questions predicts the number of defects in subsequent testing at the significance level of 0.05.
A Review of Monkeypox: The New Global Health Emergency
Authors: Rajsri Kritika Srinivasan , Rao Mana
Published: September 2022

Monkeypox, once a rare zoonotic disease, has been endemic to some African countries since its original identification among humans in 1970. Since then, cases in non-endemic regions have been linked to returning travelers or those who had contact with transported animals. The causative agent, Monkeypox virus, belongs to Orthopoxviruses, the same family as Variola—the causative organism for smallpox. Although most monkeypox outbreaks until recently were linked to zoonotic transmission, secondary human–human transmission in smallpox-unvaccinated individuals was observed in a small proportion of overall cases. Smallpox was declared to be eradicated in 1980, and since its eradication, Monkeypox virus has been the most significant poxvirus to cause human disease. The 2022 monkeypox outbreak marks a significant paradigm shift in the human and poxvirus association, with new modes of transmission and concerns of viral evolution and entrenchment as a sexually transmitted disease. Monkeypox clinically resembles smallpox but is far milder. At this time, there are no approved therapies for monkeypox, and antiviral agents effective against smallpox are being utilized. Additionally, preventive strategies being utilized include smallpox vaccinations such as JYNNEOS and ACAM2000. In this narrative review, we discuss the virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox.
Turismo comunitario y resiliencia: entre la sinergia y la literatura científica emergente
Authors: Chontasi David , Chicaiza Tatiana , Noguera Dayana , Naula Luis , Duarte Carolina
Published: September 2022

El objetivo de la investigación fue determinar el tipo de contribuciones científicas generadas alrededor del turismo comunitario y la resiliencia en Latinoamérica a lo largo de los últimos diez años de modo que sea un aporte para recientes investigadores dentro del área de estudio. Para ello, fue necesario la aplicación metodológica cualitativa a través del análisis documental en donde se identificó, revisó y clasificó de forma rigurosa la literatura especializada. La aplicación metodológica permitió delinear los resultados bajo tres criterios de análisis: fundamentos teóricos utilizados, finalidad de articular turismo comunitario y resiliencia, y uso de marco teórico-metodológicos frameworks de evaluación de resiliencia en turismo comunitario y que demuestren la capacidad adaptativa comunitaria. Los hallazgos permiten deducir que la vinculación del turismo comunitario y la resiliencia como áreas de interés académico y científico es emergente y que está ganando incidencia en Latinoamérica, especialmente en países como México, Costa Rica, Ecuador.
Free and forced vibration analysis of a Z-shaped structure with multi-span elastic supports
Authors: Liu Wei , Shi Kai , Li Jieyu , Sun Hailong , Zhao Qiang
Published: September 2022

In this paper, an in-plane Z-shaped structure with multi-span elastic supports is proposed to investigate the natural frequency and transmission response through employing in-plane governing equation and transfer matrix method. Based on the solutions of transverse vibration and torsional
vibration, the total transfer matrix for the Z-shaped structure with multi-span elastic supports is derived. Furthermore, natural frequencies and mode shapes of the Z-shaped structure are calculated. Finite element simulation method (FEM) is conducted here to verify the theoretical results.
In order to effectively evaluate the vibration reduction performance, transmission response of the Z-shaped structure under different boundary supports and multi-span elastic supports is analyzed. This work is significant for the vibration reduction of in-plane Z-shaped structure, especially
the multi-span elastic support case in engineering applications.
Determinants of adaptive behavior of a master's student of psychological and pedagogical education as a subject of scientific reflection
Authors: Svetlana-Aligaryevna Minyurova , Jennet-Kamilyevna Aminova
Published: September 2022

The article reveals the current views of the professional community on adaptive behavior, the ideas of transition to the development of a relatively stable personality structure of a master's student of psychological and pedagogical education. The data were obtained using the methods of psychological diagnostics: a multi-level personal questionnaire (MLO) "Adaptability", the questionnaire " SOP-2 "(Tendency to deviant behavior), the method "Depersonalization by professional systems", the analysis of educational activities with a focus on the method of cases, social assessments, individual conversations. Considering the current state, problems and diagnostic assessments, it can be reached the logical conclusion that the determinants of the formation and development of adaptive behavior are the dialectical laws of the development of matter, and the totality of indicators of individual personal adaptive potential, the tendency to deviate behavior, life satisfaction and educational effectiveness will determine the level of the studied behavior.
Potret Integrasi Islam dan Budaya Era Walisongo
Authors: Adib Hamdan
Published: September 2022

Sampai dengan saat ini bentuk ini masih banyak sekali bentuk budaya yang dipermasalahankan karena bukan bawaan asli agama Islam yang ada di Arab. Budaya yang ada di Indonesia yang seberapa bagian sudah menyatakan dan mengakui bahwa budaya itu menjadi ciri Islam yang ada di Indonesia oleh sebagian lainnya di tentang karena memang tak ada dalil sejarah ataupun Naqli yang membuktikannya. Maka dalam penelitian ini akan dijelaskan mengenai kajian integrasi yang ada di Nusantara ini yang dimulai sejak era walisongo dan eksis sampai dengan sekarang. Metode yang digunakan dalam penelitian ini yaitu kualitatif library research dimana peneliti akan melakukan kajian ke dalam berbagai literatur yang berkaitan dengan Islam dan Budaya yang ada di Nusantara dari berbagai dokumen. Hasil yang ditemukan yaitu islam di jawa dimana masyarakat jawa masih mempertahankan tahlilan, slametan dan budaya yang melekat pada masyarakat yang sudah berbuah nilainya dari yang awalnya bercorak hindu budha berubah menjadi Islami, selain itu sistem pendidikan pesantren juga mewarnai integrasi ini, islam di sumatra yang didukung oleh tiga kekuatan, yaitu pesantren, pasar dan istana, serta islam yang ada di Indonesia timur dilakukan oleh murid-murid dari salah satu walisngo yang ada di pulau Jawa. Melalui penelitian ini maka akan ditemukan baik secara teoritik mengenai integrasi Islam dan budaya nusantara serta praktik yang terjadi.
Potret Ideal Sikap Moderat Kiai di Era Millenial
Authors: Dzulqarnain Muhammad Idlom
Published: September 2022

Abstract Problem pecahnya persatuan menjadi masalah laten sekaligus ancaman keutuhan bangsa. Perpecahan dan konflik ideologi tidak hanya terjadi antar agama, ras, atau kelompok. Perpecahan dan disintegrasi juga rentan terjadi antar pemuka agama atau kiai, dan antar santri. Mulai dari akibat fanatisme buta, pemikiran yang kolot, dan kurangnya kesadaran toleransi. Oleh karena itu perlu ada kesadaran kiai untuk bersikap moderat. Karena pemikiran kiai memiliki banyak pengaruh terhadap para santri. Tujuan penelitian ini untuk menganalisis bagaimana indikator moderat, serta potret ideal sikap moderat kiai. Penelitian ini menggunakan metode kualitatif dan analisis deskriptif. Hasil penelitian menujukkan beberapa inidikator moderat kiai dapat dipetakan pada empat aspek. Pertama, aspek aqidah atau ideologi.  Para kiai dalam menggunakan dalil perlu seimbang antara dalil naqli maupun dalil aqli, sehingga tidak mudah memvonis orang lain salah. Kedua, aspek sosial. Para kiai perlu bergaul dengan semua golongan, mengutamakan urusan bersama, dan perdamaian. Ketiga, aspek budaya. Kiai perlu menekankan preventif daripada punishment dengan kekerasan, demokratis dan membiasakan budaya musyawarah dalam memutuskan perkara. Budaya toleransi dengan tetap menjaga budaya atau metode lama yang baik, dan tetap terbuka dengan kebaruan atau teknologi. Keempat, aspek kebangsaan. Kiai perlu menjaga eksistensi kesatuan bangsa dengan menjunjung sikap toleransi, menghormati serta menaati pemerintah selama tidak menyimpang dari norma dan agama, menyampaikan pendapat atau kritik kepada penguasa dengan cara bijak tanpa kekerasan. Keywords: kiai, moderat, pesantren.
Tantangan Dakwah: Tinjauan Faktual Kekosongan Dai Pada Bulan Suci Ramadhan Di Masjid Darussalam Kampung Pisang Kota Sorong
Authors: Faradillah Sitti Mutia
Published: September 2022

The purpose of the study to examine the factors causing the constrained activities of da'wah in the holy month of Ramadan in the Darussalam Mosque Kampung Pisang Sorong City west Papua. The da'wah activity in question is a routine lecture by the dai (preachers) conducted every night of ramadan that has been programmed by the Ministry of Religious Affairs of Sorong City. This research uses qualitative research type. As for data collection, researchers use interview methods to primary informants, namely the management of The Darussalam Mosque Kampung Pisang, the dai / mubaligh listed in the schedule of lectures, worshipers (mad'u) Darussalam Mosque Kampung Pisang, and the Ministry of Religious Affairs that compiled the schedule of the lecture. As for the observation method, the author directly observes the situation in the field both from BKM / the manager of The Darussalam Mosque Kampung Pisang, Jamaah (mad'u) Masjid Darussalam Kampung Pisang, the dais listed in the lecture schedule, and the Ministry of Religion. This research is expected to be a reference in overcoming the vacancy according to the causative factors in the holy month of Ramadan throughout the Mosque, especially in the Darussalam Mosque Kampung Pisang. Thus da'wah activities can run well without any obstacles.
Experimental Composite Indicators of Cyclical Response in Surveys of Consumer Expectations of the Population
Authors: Kitrar L. A. , Lipkind T. M. , Ustinova R. A.
Published: September 2022

The article proposes a theoretical rationale and procedure for constructing new composite indicators that combine the results of quarterly consumer expectations surveys conducted by the Federal State Statistics Service (Rosstat). The information capabilities of surveys for the period 2005–2021 were studied to find the best alternative to the traditional consumer confidence index in the context of early estimates of the growth in household final consumption. The experimental Consumer Behavior Index reflects the «common profile» in the changes in the key parameters of consumer activity. The index is based on time series of primary survey indicators with high cross-correlation coefficients and a confirmed statistically significant causal relationship with a statistical referent – the growth rate of the final consumption expenditure of households. The new Consumer Anxiety Index with a counter-directional profile assesses the scale and tendencies of household response to market shocks based on short-term gaps between the indicator components and their long-term average.In accordance with the proposed procedure for statistical testing of the time series, a cross-correlation analysis was carried out. Granger causality was studied, principal component analyses applied, unobservable cyclical components were identified in the dynamics of the Consumer Behavior Index and the referent using Hodrick – Prescott, Christian – Fitzgerald and Kalman statistical filters, and phase-by-phase movement of these components is demonstrated. A statistically significant cyclical correspondence and a close relationship of leading and coinciding nature between the composite survey-based index and the growth rate of the final consumption expenditure of households were confirmed.
Some Aspects of Methodological Support of Bank Value Management in the Russian Market of Financial Services
Authors: Polyakov K. L. , Polyakova M. V. , Zagonova E. A.
Published: September 2022

In the introduction, the authors argue the relevance of the researched problem of improving the algorithm for estimating transaction cost of bank’s purchase and sale in the Russian financial services market. It is emphasized that the need to manage the value of a commercial enterprise arises not only when planning the purchase and sale transaction of the entire business or part of it. The valuation is taken into account, first of all, when corporatizing an organization, attracting new shareholders, insuring its property, obtaining a loan secured by property, calculating the fair value of taxes.The first part of the paper substantiates the business valuation algorithm intended for a potential investor and adapted to the conditions of the Russian financial market. This takes into account the specific features of each bank in question. Based on the data from open financial statements (for 2017–2022), the parameters required in the procedure for obtaining estimates are calculated.The second part of the paper presents the result of selecting indicators of the external and internal economic environment of banks that have a significant statistical relationship with the resulting valuation. The selected factors are under the control of managers and can be used to guide the proposed cost estimate. Data were obtained on the direction and strength of influence of selected factors on the value of business. The selection algorithm is based on mathematical modeling using bank data for the period under consideration.The valuation is based on a comparative approach, where the values of the multiples are calculated using a linear regression model. To organize cost management, a panel regression model is built, which allows to select significant financial indicators and determine the nature of their impact on the bank's value.
The Essentials of Paragraph Writing to Develop Writing Skill
Authors: Rahman Md Mohidur
Published: September 2022

Paragraph is a group of related sentences dealing with a central idea. It is important to practice writing, develop writing skill, organize thoughts and improve the bent of expression. It starts with an attitude in the topic sentence, develops coherently and cohesively with the supporting ideas and ends with the restatement of the theme of the topic sentence. It requires two important factors – free hand writing and in-depth knowledge on the rules of introducing, developing, modulating and terminating. Besides, the unity, logical arrangement of supporting ideas, coherence, cohesion, completeness etc are the important elements of paragraph. But there is a false allegation to paragraph writing. Most of our teachers say that paragraph has no rules. For this, our students commit it for examination only and as such, suffer from poor writing skill. Thus, this paper aims at finding out the theories or rules of paragraph writing for writing practice and developing their writing skill.
CARACTERÍSTICAS FÍSICO-QUÍMICAS DA CAMA DE AVIÁRIO E DESEMPENHO DE FRANGOS DE CORTE ALOJADOS EM DIFERENTES MATERIAIS DE CAMA E DUAS DENSIDADES
Authors: De Almeida Brainer Mônica Maria , De Souza Martins Jean , Bonifácia Marra da Silva Valéria , Baleroni Rodrigues de Godoy Heloísa , Fabino Neto Ronaildo
Published: September 2022

A cama de aviário é utilizada para absorver umidade e se tornar uma barreira do contato direto da ave com o chão em sistemas intensivos de criação. Desse modo, contribui para o bem-estar e melhor desempenho produtivo das aves por reduzir as mudanças bruscas de temperatura nos galpões. O objetivo deste trabalho foi avaliar as características físico-químicas de quatro tipos de material de cama aviária sob duas densidades de alojamento e o desempenho de frangos de corte alojados nos diferentes tratamentos no período de 42 dias. Foi adotado o delineamento experimental inteiramente ao acaso, em um esquema fatorial 4 x 2 (quatro tipos de material de cama e duas taxas de lotação) e cinco repetições. Os quatro tipos de material de cama foram areia lavada, maravalha, casca de arroz e feno de Tifton 85 e as duas taxas de lotação foram 10 e 14 aves/m2. Os parâmetros de desempenho dos animais avaliados foram: ganho de peso, consumo, conversão alimentar, peso vivo e viabilidade, enquanto que as características analisadas da cama foram: pH, temperatura e umidade. Os materiais de cama aviária utilizados não afetaram negativamente o desempenho das aves, entretanto as aves alojadas na densidade de 10 aves/m2 apresentam melhor desempenho. Não houve diferença entre os valores de pH e temperatura dos diferentes tratamentos, entretanto a umidade da cama de areia na densidade de 10 aves/m2 foi significativamente maior que a dos demais materiais. Portanto, os materiais de cama aviária utilizados nesse estudo apresentaram características físico-químicas semelhantes, sendo que a areia lavada tem maior poder de absorção de água, mas, mesmo assim, não afetou negativamente o desempenho das aves. As aves alojadas na densidade de 10 aves/m2 apresentaram melhor desempenho.
INVESTIGAÇÃO DE EVENTO ADVERSO ASSOCIADO À VACINAÇÃO ANTIRRÁBICA
Authors: De Paula Júnior Rogério Augusto
Published: September 2022

A raiva é uma antropozoonose endêmica no Brasil. O animal infectado transmite o vírus rábico principalmente através de mordeduras. Por muitos anos cães e gatos representaram a principal fonte de infecção para seres humanos em áreas urbanas. Desde o ano de 1973, o Programa Nacional de Profilaxia da Raiva estabelece que cães e gatos devem ser imunizados contra raiva. A vacinação animal é um meio seguro, confiável e eficaz para proteger animais contra doenças infecciosas e prevenir a transmissão de zoonoses, contudo a administração de vacinas não é isenta de riscos. Portanto as ocorrências de evento adverso associados à vacinação devem ser investigadas, pois a demonstração da segurança das vacinas contribuiu para o sucesso dos programas de imunização. Este estudo descreve o relato de caso de um animal suspeito de apresentar reação adversa à vacinação antirrábica.
PEIXES PEÇONHENTOS DO BAIXO TIETÊ
Authors: Saraiva Rocha Moreira Isleide , HADDAD JUNIOR VIDAL
Published: September 2022

O rio Tietê faz parte de uma das principais hidrovias do Brasil, a hidrovia Paraná – Tietê, sendo grande fonte de subsistência para os pescadores que possuem risco na atividade devido peixes que podem causar acidentes traumatizantes e envenenamento por inoculação de veneno através de algum aparato ósseo, como ferrão. A arraia fluvial possui ferrão na cauda e causa ferimento de grande importância podendo afastar o pescador de suas atividades por um longo período, devido à demora da cicatrização do ferimento.
Neologismos con prefijos productivos
Authors: Pierabella Silvana Elide
Published: September 2022

El siguiente artículo brinda información sobre el método empleado en la detección automática de neologismos dentro de un corpus tratado con la herramienta NooJ, la cual es utilizada por investigaciones académicas en todo el mundo, dado que puede configurarse para cualquier idioma.
Results of Ixodes Tick-Borne Borreliosis Monitoring in Crimea in 2015–2021
Authors: Kovalenko  , Sitnikova Alexandra L. , Zinich  , Yakunin  , Abibulaev Dlyaver E. , Vladychak  , Poluektova  , Pidchenko  , Tikhonov Sergey N.
Published: September 2022

Introduction: The studies of borreliosis and the official disease registration in Crimea began in the year 2000. An obvious increase in the number of human cases of Ixodes tick-borne borreliosis has been observed since then: 204 cases of Lyme disease were registered in Crimea in 2000–2014 and already 324 cases in the years 2015–2021.
Objective: To specify reservoirs, vectors and boundaries of natural foci of tick-borne borreliosis in Crimea based on the results of research conducted in 2015–2021.
Materials and methods: Collection of Ixodes ticks and trapping of small mammals were carried out in all administrative areas in different landscape zones of the Crimea. The field material was delivered to the laboratory, where it was identified, pooled, and investigated using molecular genetic methods. Geoinformation technologies were used to map the results.
Results and discussion: The majority of positive markers of tick-borne borreliosis were found in pools of Ixodes ticks in the Mountain and Foothill area while positive samples from small mammals were detected in the Steppe part of the peninsula. The dominant species of reservoirs (gen. Crocidura, Cricetulus, Rattus) and vectors (gen. Ixodes) of tick-borne borreliosis in Crimea in the years 2015–2021 were identified.
Conclusion: Lyme borreliosis is distributed almost throughout the whole territory of the Crimean Peninsula. A systematic local monitoring of reservoirs and vectors of tick-borne borreliosis is important to clarify the features of activity of natural foci in different natural zones, to determine the diversity of Borrelia species, and to assess the disease risk for humans.
İç Ortam Kalitesinin Önemi Üzerine Bir Araştırma
Authors: BULUT KARACA Ülger
Published: September 2022

Günümüzde insanlar zamanlarının büyük bölümünü konut, ofis, okul gibi kapalı mekânda geçirmektedir. Son yıllarda yaygın olarak görülen hasta bina sendromu, bina kaynaklı hastalıklar, okullarda öğrenim performansının ve ofis ortamlarında çalışanların verimliliklerinin azalması gibi sağlık ve verimlilik sorunları iç ortam kalitesi ile ilişkilendirilmektedir. Bu çalışmada iç ortam kalitesi ve sürdürülebilir bina kavramları ilişkilendirilerek, insan sağlığı ve verimliliği konularında iç ortam kalitesinin (iok) önemine dikkat çekmek amaçlanmaktadır. Bu çalışma kapsamında iok’ni belirleyen parametrelerden aktif olarak ölçülebilen ve kontrol edilebilen ısıl konfor, iç hava kalitesi, aydınlatma ve görsel konfor, akustik konfor ele alınmıştır. İok ile ilgili standart ve literatür taraması ile elde edilen bulgular sonucunda bu parametrelerin tanımları, kullanıcı üzerindeki etkileri, ölçülme yöntemleri ve yeşil bina sertifikasyon sistemleri ile ilişkileri ele alınmıştır. Sonuçta, iok'nin çalışmada ele alınan temel parametrelerinin, bina kullanıcılarının sağlığı ve üretkenliği ile ilişkili olduğu; dikkate alınmasında önemli sağlık ve finansal yararlar olduğu; iç ortamdaki fiziksel koşulların, uygun tasarım ve bina işletim sistemleri ile karşılanabileceği, yeşil bina sertifika sistemlerinin binalarda iok’nin gelişimine katkı sağladığı sonuçlarına ulaşılmıştır.
Ilqo’; Strategi Peningkatan Keterampilan Berbicara Di Pondok Pesantren Salafiyah Syafi’iyah
Authors: Hanun Aisyatul
Published: September 2022

This research is based on increasing the Santri’s interest in learning Arabic language in Islamic Boarding School of Salafiyah Syafiiyah Sukorejo Situbondo. It can be seen from various dorm areas which have been designed a particular room to learn Arabic even almost every complex. However, each complex has a different learning strategy. so, the effect on learning resultwill be different.

Based on perceptions from different sides, learning Arabic in syafahiyah is not as easy as learning Arabic theories “nahwu-sharraf”. Meanwhile, Islamic boarding school environment that tends to use the classic system, learn more Arabic to comprehend classic books. For this reason, it is necessary to accentuate the purpose of every learning process.

In learning maharah al-kalam that was held in Salafiyah Syafi'iyah Sukorejo Situbondo boarding school, that is El-Marwah community used “ilqa strategy” to make students easier to apply vocabulary which has been memorized everyday and get more newmufrodat in every discussion process, in addition students are more confident to communicate in Arabic.
Perancangan dan Implemantasi Sistem Overall Equipment Effectiveness (OEE) in Production Berbasis Web dan Programmable Logic Controller (PLC) menggunakan Sensor Keyence di PT. Penstone Auto Indonesia
Authors: Sidik Abdul , Wahidin Mokhamad , Elanda Anggi
Published: September 2022

Penelitian ini bertujuan untuk merancang sebuah sistem untuk mengetahui jumlah product yang OK dan Reject pada produksi setiap hari berbasis web pada PT.Penstone Auto Indonesia. Pada PT tersebut selama proses produksi terdapat beberapa permasalahan yang muncul diantaranya belum adanya pengukuran workingtime dan cycletime pada mesin Blowmolding-Injection sehingga tidak dapat diketahui efektifitas dari kinerja mesin  Blowmolding-Injection, juga proses Quality Assurance (QA) dan pelaporan Report masih dilakukan secara manual. Metode penelitian yang digunakan adalah metode penelitian kualitatif dengan desain penelitian yaitu DSR (Design Science Research) yang memiliki 6 tahapan yaitu identifikasi masalah, identifikasi objek dari solusi, desain dan pengembangan, demonstrasi, evaluasi dan komunikasi.  Dari hasil penelitian yang di lakukan dengan pengembangan sistem informasi OEE pada PT. Penstone Auto Indonesia di dapatkan nilai workingtime dan cycletime sehingga dapat diketahui efektifitas dari kinerja mesin Blowmolding-Injection.
ПРО ІНТЕГРОВАНИЙ ПІДХІД ДО ПРОЦЕСУ ВИКОРИСТАННЯ ДУХОВНОГО ПОТЕНЦІАЛУ ДЕРЖАВИ У ЗБРОЙНИХ СИЛАХ
Authors: Голота Анатолій
Published: September 2022

Яскравим прикладом інтегрованого підходу до модернізації науки є синтез, або процес конвергенції системи морально-психологічного забезпечення (МПЗ) та стратегічних комунікацій (СК) Збройних Сил України, як складової стратегічних комунікацій держави. Про цей процес сказано вже чимало, але важливо відмітити, що це має стати значною подією у військовій науці і вона напряму пов’язана з агресією Росії в Україні.
ВИВЧЕННЯ НАКОПИЧЕННЯ ВАЖКИХ МЕТАЛІВ ОВОЧАМИ ЗА РІЗНОГО ПЕРІОДУ ЇХ ВЕГЕТАЦІЇ
Authors: Піддубна Антоніна
Published: September 2022

Овочівництво – важлива галузь сільськогосподарського виробництва, яка забезпечує населення різноманітним асортиментом високопоживних продуктів харчування з високим вмістом біологічно активних речовин, які сприяють поліпшенню обміну речовин та забезпечують нормальний розвиток і функціонування організму людини, підвищуючи його стійкість до несприятливих факторів.
МОНІТОРИНГ ЯКОСТІ ТА БЕЗПЕЧНОСТІ КОРМІВ ДЛЯ ТВАРИН ЗА МІКРОБІОЛОГІЧНИМИ КРИТЕРІЯМИ
Authors: Кравцова Оксана , Чечет Ольга , Гайдей Ольга , Шуляк Світлана , Гереймович Віолетта , Марчук Ольга
Published: September 2022

У статті описано аналіз державного моніторингу кормів на 2021 рік за мікробіологічними критеріями якості і безпеки, що проводився Державним науково-дослідним інститутом з лабораторної діагностики та ветеринарно-санітарної експертизи, регіональними державними лабораторіями Держпродспоживслужби України. Проведена робота спрямована на оцінки якості та безпеки кормів згідно заходів та умов, необхідних для здійснення контролю небезпечних факторів і забезпечення придатності кормів з урахуванням їх використання згідно із призначенням відповідно до Закону України “Про безпечність та гігієну кормів” [1]. Результати моніторингових досліджень надали інформацію про рівень контамінації кормів умовно-патогенними та патогенними мікроорганізмами. Була встановлена невідповідність деяких зразків кормів вимогам щодо безпеки за наявністю патогенних мікроорганізмів. З огляду на це актуальними є заходи направлені на недопущення ризиків для здоров’я тварин і людини, пов’язаних як з кормами безпосередньо, так і з навколишнім середовищем, забезпечення випуску якісної продукції та попередження потрапляння до організму людини умовно-патогенної та патогенної мікрофлори, що становлять загрозу для здоров’я. Моніторинг показників якості та безпеки кормів сприяє досягненню благополуччя тварин та їх високої продуктивності, а також отримання безпечної та якісної продукції тваринного походження, а значить і забезпечення доброго здоров'я населення.
ІМІТАТОР ШВИДКИХ ЗАВМИРАНЬ БАГАТОПРОМЕНЕВОГО КАНАЛУ ЗВ'ЯЗКУ
Authors: Магомедова Марія , Почерняєв Віталій
Published: September 2022

При побудові імітатора швидких завмирань необхідно розробити пристрій, що генерують процес з чотирьохпараметричним законом розподілу амплітуди і фаз сигналу (імітатор закону розподілу); пристрій, що автоматично управляє змінами параметрів цього закону (облаштування управління параметрами - ОУП); облаштування перенесення сформованих завмирань на досліджуваний сигнал.