bluuebunny/crossref_metadata_2025 huggingface dataset:
The spark of life: discharge physics as a key aspect of the Miller–Urey experiment
Authors: Longo Savino
Published: April 2024

The Miller–Urey experiment demonstrated the possibility of producing biomolecules from the chemical components of the primordial atmosphere, using an electric discharge. It profoundly influenced the development of prebiotic chemistry and astrobiology. The essential aspect of the experiment is the action of the electric field on a gaseous mixture, which produces chemically active species. These last react to ultimately form biomolecules. In this work the hypotheses and methods used to describe the chemical activation of a gas by an electric field, used in computational chemistry and in the physics of electrical discharges, are contrasted, showing that the second provides a much more realistic description of the primary events. A future model should combine the insights of the two communities to bring forth a faithful and insightful description of the experiment, from the primary events to the formation of biomolecules.
Parenting by mothers from marginalized communities and the role of socioeconomic disadvantage: insights from marginalized Roma communities in Slovakia
Authors: Van Laer Stanislava , Fiľakovská Bobáková Daniela , Kolarcik Peter , Engel Ofer , Madarasová Gecková Andrea , Reijneveld Sijmen A. , de Kroon Marlou L. A.
Published: April 2024

Background

Roma living in marginalized communities often face poor living conditions and material deprivation, which may negatively impact parenting. Our aim is to compare the parenting behavior (support, harsh discipline, and stimulation) of mothers from marginalized Roma communities and the majority population in Slovakia. We also examine the role of socioeconomic disadvantage and related worries in the differences in parenting behavior between these groups.

Methods

We obtained cross-sectional data from mothers of children aged 14–18 months using the first wave of the longitudinal RomaREACH study dataset. Two groups were included in the sample: 93 mothers from MRCs and 102 mothers from the majority. We performed multiple regression and mediation analyses to assess whether the educational level of mothers, the degree of poverty, and poverty-related feelings of stress and worries explain parenting behavior differences between the groups of mothers.

Results

We found significant differences in parenting, especially in harsh disciplining and stimulation. These two domains were significantly associated with maternal education, degree of poverty, and poverty-related stress and worries. The degree of poverty partially mediated stimulation differences between the two groups of mothers.

Conclusion

Parenting in MRCs seems harsher and less stimulative than parenting in the Slovak majority. These differences are associated with the socioeconomic disadvantage of mothers. The degree of poverty partially explains why parenting in MRCs is less stimulative. These results may inform intervention efforts aimed at disadvantaged families.
Temperament and emotional overeating: the mediating role of caregiver response to children’s negative emotions
Authors: Ju Sehyun , Iwinski Samantha , Bost Kelly K.
Published: April 2024

Objective

This study aimed to investigate the mediating effects of caregiver responses to a child’s negative emotions on the associations between infant temperament and emotional overeating in preschool children.

Method

A sample of 358 children and their caregivers enrolled in the STRONG Kids 2 (SK2) birth cohort study (N = 468) provided data for this analysis. Caregivers completed questionnaires assessing child temperament at 3 months, caregiver response to negative emotions at 18 months, and child emotional overeating at 36 months. Structural Equation Modeling was conducted using the lavaan package in RStudio to test hypothesized models examining whether the relations between early temperament and subsequent emotional eating were mediated by caregiver responses to a child’s emotions.

Results

Findings revealed that infant temperamental orienting/regulation predicted the later development of emotional overeating through supportive caregiver responses to a child’s negative emotions. Lower levels of orienting/regulation were associated with greater emotional overeating, explained by less supportive caregiver responses to the child’s emotions. Moreover, infant surgency had a positive direct influence on emotional overeating at 36 months. Both supportive and non-supportive caregiver responses to a child’s negative emotions had significant direct influences on emotional overeating.

Conclusion

The results highlight the importance of caregiver response to a child’s negative emotions as a mediator between infant temperament and emotional overeating in preschool children. Intervention strategies can be implemented to support caregivers in adopting supportive responses to their child’s negative emotions to promote healthy eating behaviors from early childhood. Future studies are needed to explore these pathways of influences throughout child development.
Exploring suicide ideation in university students: sleep quality, social media, self-esteem, and barriers to seeking psychological help
Authors: Landa-Blanco Miguel , Romero Karol , Caballero Ivin , Gálvez-Pineda Ernesto , Fúnes-Henríquez María José , Romero Rina
Published: April 2024

The purpose of the current study is to analyze how variations in suicidal ideation scores can relate to sleep quality, social media consumption, self-esteem, and perceived barriers to seeking psychological help in a sample of university students in Honduras. A quantitative cross-sectional design was used. Self-reported data was collected from a non-random sample of 910 university students in Honduras; their average age was 24.03 years (SD=6.05). Most respondents were women (67%) with men accounting for 33% of the sample. Measurements included item 9 of the Patient Health Questionnaire-9, the Single-Item Sleep Quality Scale, Rosenberg’s Self-Esteem Scale, Barriers to Seeking Psychological Help Scale for College Students, and a self-reported questionnaire on social media. In response to the query, “Over the past two weeks, how frequently have you experienced thoughts that you would be better off dead or of hurting yourself?” 54% (n=495) of participants indicated “not at all” 18% (n=168) reported “several days” 14% (n=129) responded “more than half of the days” and 13% (n=118) stated “nearly every day”. The results from the ordinal logistic regression model indicate that sleep quality and self-esteem serve as protective factors associated with decreased suicide ideation. At the same time, a higher number of social media platforms used per week and perceived barriers to seeking psychological help increase suicide ideation. Altogether, these variables explained 19% of the variance in suicidal ideation scores. Suicidal ideation is highly prevalent among the sampled university students.
Damage to the public health system caused by war-related looting or vandalism in the Tigray region of Northern Ethiopia
Authors: Gufue Zenawi Hagos , Haftu Hiluf Kalayou , Alemayehu Yibrah , Tsegay Etsay Weldekidan , Mengesha Meresa Berwo , Dessalegn Berhe
Published: April 2024

Background

The war that started on November 4, 2020, in the Tigray region of Northern Ethiopia severely affected the health sector. However, there is no available evidence to suggest the economic damage caused to the public health system because of war-related looting or vandalism. This study was aimed at estimating the cost of war-related looting or vandalism in Tigray’s public health system in Northern Ethiopia in 2021.

Methods

A provider perspective, a mixed costing method, a retrospective cross-sectional approach, a 50% inflation rate, and a 50 Ethiopian birr equivalent to one United States dollar ($) for the money value were used. The data were analyzed using Microsoft Excel, taking into consideration the Sendai framework indicators.

Results

The total economic cost of the war-related looting or vandalism in monetary terms was more than $3.78 billion, and the damage to the economic value in monetary terms was more than $2.31 billion. Meanwhile, the direct economic loss to the health system in monetary terms was more than $511 million. According to this assessment, 514 (80.6%) health posts, 153 (73.6%) health centers, 16 (80%) primary hospitals, 10 (83.3%) general hospitals, and 2 (100%) specialized hospitals were damaged and/or vandalized either fully or partially due to the war.

Conclusion

This war seriously affected the public health sector in the Tigray region. The Federal Government of Ethiopia, the Ministry of Health of Ethiopia, the Tigrayan Government, the Tigray Regional Health Bureau, and the international community must make efforts to find resources for the revitalization of the damaged, plundered, and vandalized healthcare system.
Assessment of burnout, resilience, and thriving among academic health professionals: findings from an international study
Authors: Nahas Abdul Rahman Fata , Elnaem Mohamed Hassan , Mubarak Naeem , Khatwa Merna Abou , Barakat Muna , Faller Erwin , Kassem Lamyaa M. , Ramatillah Diana Laila , Jaber Ammar , Akkawi Muhammad Eid , Al-Shami Abdulkareem Mohammed , Chandran Sarath , Mohamed Islam , Jack Iain , Abouelhana Ahmed , Courtenay Aaron , Elrggal Mahmoud E.
Published: April 2024

Introduction

Burnout, resilience, and thriving significantly impact academics, particularly in health professions, where responsibilities are extensive. This study aimed to explore these constructs among academic health professionals, examining sociodemographic and work-related factors influencing these outcomes.

Methods

A cross-sectional study was conducted among academic health professionals via web-based professional networks from August 2022 to February 2023. Validated tools were used, and descriptive and inferential statistics were applied.

Results

505 participants were included, predominantly female (63%), with a mean age of 38.15 ± 9.6 years. High burnout was reported by 10.9%, 13.7% experienced exhaustion, and 6.3% were disengaged. Resilience and thriving were moderate at 59.2 and 51.9%, respectively. Age correlated negatively with burnout (r = −0.131, p = 0.003) but positively with resilience (r = 0.178, p < 0.001). Females reported higher exhaustion (p = 0.014), while males showed greater resilience (p = 0.016). Instructors exhibited lower resilience compared to assistant professors (p < 0.001) and associate professors (p < 0.001). Those at public universities reported higher exhaustion than those at private universities (p < 0.001).

Conclusion

Variable levels of burnout, resilience, and thriving were observed among academic health professionals, influenced by sociodemographic and work-related factors. Interventions targeting resilience and thriving may mitigate burnout risk and enhance engagement among academics in health professions.
Application of machine learning for lung cancer survival prognostication—A systematic review and meta-analysis
Authors: Didier Alexander J. , Nigro Anthony , Noori Zaid , Omballi Mohamed A. , Pappada Scott M. , Hamouda Danae M.
Published: April 2024

Introduction

Machine learning (ML) techniques have gained increasing attention in the field of healthcare, including predicting outcomes in patients with lung cancer. ML has the potential to enhance prognostication in lung cancer patients and improve clinical decision-making. In this systematic review and meta-analysis, we aimed to evaluate the performance of ML models compared to logistic regression (LR) models in predicting overall survival in patients with lung cancer.

Methods

We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. A comprehensive search was conducted in Medline, Embase, and Cochrane databases using a predefined search query. Two independent reviewers screened abstracts and conflicts were resolved by a third reviewer. Inclusion and exclusion criteria were applied to select eligible studies. Risk of bias assessment was performed using predefined criteria. Data extraction was conducted using the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies (CHARMS) checklist. Meta-analytic analysis was performed to compare the discriminative ability of ML and LR models.

Results

The literature search resulted in 3,635 studies, and 12 studies with a total of 211,068 patients were included in the analysis. Six studies reported confidence intervals and were included in the meta-analysis. The performance of ML models varied across studies, with C-statistics ranging from 0.60 to 0.85. The pooled analysis showed that ML models had higher discriminative ability compared to LR models, with a weighted average C-statistic of 0.78 for ML models compared to 0.70 for LR models.

Conclusion

Machine learning models show promise in predicting overall survival in patients with lung cancer, with superior discriminative ability compared to logistic regression models. However, further validation and standardization of ML models are needed before their widespread implementation in clinical practice. Future research should focus on addressing the limitations of the current literature, such as potential bias and heterogeneity among studies, to improve the accuracy and generalizability of ML models for predicting outcomes in patients with lung cancer. Further research and development of ML models in this field may lead to improved patient outcomes and personalized treatment strategies.
The effect of land cover on the foraging behavior and pollen in the honey of the giant bee Apis dorsata in Sumatra
Authors: Raffiudin Rika , Dyahastuti Meis , Nugraha Rahmia , Sayusti Tiara , Djuita Nina Ratna , Suwananda Erik , Allvioningrum Vera , Mardhony Reza , Biagioni Siria , Setyaningsih Christina Ani , Prasetyo Lilik Budi , Priawandiputra Windra , Atmowidi Tri , Saad Asmadi , Behling Hermann
Published: April 2024

Introduction

Apis dorsata, the common bee pollinator in tropical forests, is experiencing a population decrease due to several anthropogenic factors that lead to land cover changes and habitat loss. Land cover changes may alter their resource supply and foraging behavior. Our study aimed to determine foraging behavior and botanical origin using pollen of A. dorsata honey in two land cover types: plantationdominated landscape (PL) in Kampar (Riau) and forest-agriculture-dominated landscape (FL) in Kerinci (Jambi) Sumatra, Indonesia.

Methods

We observed two colonies of A. dorsata flight direction and flight activities in each land cover from 9 am–3pm. Honey was harvested from both nests of A. dorsata and the pollen in the honey was analyzed using acetolysis procedure. Vegetation analysis in both locations was conducted based on the flight directions of the giant honey bees.

Results

The foraging data of A. dorsata showed a difference in the total number of bees between these two land cover types. The number of bees flying out and returning to the nest was higher in Kerinci than in Kampar, while high morning foraging activities were recorded in both land cover types. Furthermore, the foraging activity of the colonies in the PL landscape, i.e., flying out and returning to the nest with and without pollen, decreased at noon. The palynological results of the honey showed that in the PL landscape, pollen diversity was very low and mainly consisted of Elaeis gueneensis pollen (97%). Meanwhile, pollen types and concentrations were much higher in the FL than in the PL.

Discussion

This result suggests that A. dorsata exhibits a more varied foraging behavior in a diverse and heterogeneous landscape in Kerinci compared to a plantation-dominated habitat in Kampar.
Apneustic anesthesia ventilation improves pulmonary function in anesthetized bottlenose dolphins (Tursiops truncatus)
Authors: Le-Bert Carolina R. , Bukoski Alex , Downs John , Hodgson David S. , Thombs Lori , Ridgway Sam H. , Bailey James
Published: April 2024

Introduction

Use of mechanical ventilation during general anesthesia is a necessary practice in the anesthetization of small cetaceans as spontaneous ventilation fails to provide adequate gas exchange. Currently available methods of ventilation do not account for the intermittent breathing strategy of representative species within this infraorder of fully aquatic mammals and may have a significant effect on cardiac and respiratory physiology.

Methods

To understand the impact of mechanical ventilation on cardiopulmonary function in one small species of cetacean, the bottlenose dolphin (Tursiops truncatus), we compared controlled mechanical ventilation (CMV) to a novel ventilation method known as apneustic anesthesia ventilation (AAV). AAV simulates the normal inspiratory breath-hold pattern of dolphins. Ten anesthetic procedures (dental procedure, n = 9; bronchoscopy, n = 2) were performed on nine dolphins (age range: 10–42 years; mean = 32 years; median = 37 years; female = 3, 40%; male = 6, 60%). In a cross-over study design, dolphins were instrumented and randomly assigned to AAV or CMV as the initial mode of ventilation, then switched to the alternate mode. Baseline cardiopulmonary data were collected and again after 30 min on each mode of ventilation. Cardiac index, stroke volume index, systemic vascular resistance, alveolar dead space, alveolar-arterial oxygen tension gradient, arterial oxygen content, oxygen delivery index, and dynamic respiratory system compliance index were calculated at each of the four time points.

Results

During AAV, dolphins had higher arterial oxygen tension, higher mean airway pressure, reduced alveolar dead space ventilation and lower alveolar-arterial oxygen difference. Cardiovascular performance was not statistically different between the two modes.

Discussion

Our study suggests AAV, which more closely resembles the conscious intermittent respiratory pattern phenotype of dolphins, improves ventilation and pulmonary function in the anesthetized dolphin. Future studies should evaluate the cardiopulmonary effects of neutral buoyancy and cardiopulmonary sparing drug protocols to reduce the need for hemodynamic support of current protocols.
Application of the HRE-S to 140 horses with trigeminal-mediated headshaking and the association of clinical signs with diagnosis, therapy, and outcome
Authors: Kloock Tanja , Hellige Maren , Kloock Anke , Feige Karsten , Niebuhr Tobias
Published: April 2024

Background

Horses with trigeminal-mediated headshaking (TMHS) exhibit different headshaking patterns (HSPs), electric shock-like jerking, signs of nasal irritation, and painful facial expressions. The History Rest and Exercise Score (HRE-S) was developed to objectively clarify the severity of the condition in affected horses. This score considers the history and severity of clinical signs at rest and exercise. This study aimed to assess the frequency of different clinical signs and their individual associations with diagnosis, treatment, and outcome in horses diagnosed with TMHS.

The clinical records of horses presented with headshaking (HS) at the Clinic for Horses, University of Veterinary Medicine Hannover, between 2006 and 2021 were assessed retrospectively for clinical signs, diagnosis, and treatment. A total of 140 horses were included in the study. Video recordings were evaluated using the HRE-S and compared to the score described by Talbot. Following discharge, owners were interviewed via telephone about the outcome. Correlations between the presence and severity of clinical signs, diagnosis, and outcome were evaluated.

Results

The following clinical signs were significantly correlated with a higher HRE-S and grade by Talbot: HS at walk (independently of HSP) (52.9%, 74/140), increased total number of demonstrated HSP (independent of the dominant HSP) (more than one HSP per horse in 91.4%, 128/140), signs of nasal irritation (75.9%, 104/137), painful facial expression (67.8%, 80/118), and electric shock-like jerking (77.5%, 107/138). Diagnosis and outcome do not correlate with the presence of the above-mentioned clinical signs.

Conclusion

The HRE-S was confirmed as a valid tool to evaluate disease severity in a cohort of 140 horses with HS. Additionally, clinical signs identified as indicators for higher disease severity may have a stronger negative effect on patient welfare, but they do not correlate with diagnosis or outcome.
Predefined Time and Accuracy Adaptive Fault-Tolerant Control for Nonlinear Systems with Multiple Faults
Authors: Su Yakun , Jiang Yaling , Tong Miao , Wang Huanqing
Published: April 2024

This work mainly studies the issue of predefined time and accuracy adaptive fault-tolerant control for strict-feedback nonlinear systems with multiple faults. The faults in the controlled system include actuator faults and external system faults. The unknown functions for nonlinear systems are approximated by fuzzy logic systems (FLSs). And then, according to the backstepping technique and the predefined time stability theory, an adaptive fuzzy control algorithm is presented, which can make sure that all closed-loop system signals remain predefined time bound and the tracking error converges to a predefined accuracy within the predefined time. Ultimately, the effectiveness of the presented control algorithm is proved through two simulation examples.
MnO2/AgNPs Composite as Flexible Electrode Material for Solid-State Hybrid Supercapacitor
Authors: Mladenova Borislava , Dimitrova Mariela , Stoyanova Antonia
Published: April 2024

A MnO2/AgNP nanocomposite was synthesized using a sonochemical method and investigated as an electrode material in a solid-state hybrid supercapacitor. Aquivion’s sodium and lithium electrolyte membrane serves as an electrolyte and separator. For comparison, MnO2 was used as the active material. The developed supercapacitor containing a carbon xerogel as a negative electrode, the MnO2/AgNP composite as a positive electrode and a Na+-exchange membrane demonstrated the highest performance characteristics. These results indicate that the incorporation of silver nanoparticles into the MnO2 structure is a prospect for obtaining an active composite electrode material for solid-state supercapacitors.
DFT Simulations Investigating the Trapping of Sulfides by 1T-LixMoS2 and 1T-LixMoS2/Graphene Hybrid Cathodes in Li-S Batteries
Authors: Babar Shumaila , Hojaji Elaheh , Cai Qiong , Lekakou Constantina
Published: April 2024

The aim of this study is to investigate new materials that can be employed as cathode hosts in Li-S batteries, which would be able to overcome the effect of the shuttling of soluble polysulfides and maximize the battery capacity and energy density. Density functional theory (DFT) simulations are used to determine the adsorption energy of lithium sulfides in two types of cathode hosts: lithiated 1T-MoS2 (1T-LixMoS2) and hybrid 1T-LixMoS2/graphene. Initial simulations of lithiated 1T-MoS2 structures led to the selection of an optimized 1T-Li0.75MoS2 structure, which was utilized for the formation of an optimized 1T-Li0.75MoS2 bilayer and a hybrid 1T-Li0.75MoS2/graphene bilayer structure. It was found that all sulfides exhibited super-high adsorption energies in the interlayer inside the 1T-Li0.75MoS2 bilayer and very good adsorption energy values in the interlayer inside the hybrid 1T-Li0.75MoS2/graphene bilayer. The placement of sulfides outside each type of bilayer, over the 1T-Li0.75MoS2 surface, yielded good adsorption energies in the range of −2 to −3.8 eV, which are higher than those over a 1T-MoS2 substrate.
Cellulose Nanocrystals Show Anti-Adherent and Anti-Biofilm Properties against Oral Microorganisms
Authors: Panio Antonella , Ionescu Andrei C. , La Ferla Barbara , Zoia Luca , Savadori Paolo , Tartaglia Gianluca M. , Brambilla Eugenio
Published: April 2024

Cellulose nanocrystals (CNCs) are cellulose-derived nanomaterials that can be easily obtained, e.g., from vegetable waste produced by circular economies. They show promising antimicrobial activity and an absence of side effects and toxicity. This study investigated the ability of CNCs to reduce microbial adherence and biofilm formation using in vitro microbiological models reproducing the oral environment. Microbial adherence by microbial strains of oral interest, Streptococcus mutans and Candida albicans, was evaluated on the surfaces of salivary pellicle-coated enamel disks in the presence of different aqueous solutions of CNCs. The anti-biofilm activity of the same CNC solutions was tested against S. mutans and an oral microcosm model based on mixed plaque inoculum using a continuous-flow bioreactor. Results showed the excellent anti-adherent activity of the CNCs against the tested strains from the lowest concentration tested (0.032 wt. %, p < 0.001). Such activity was significantly higher against S. mutans than against C. albicans (p < 0.01), suggesting a selective anti-adherent activity against pathogenic strains. At the same time, there was a minimal, albeit significant, anti-biofilm activity (0.5 and 4 wt. % CNC solution for S. mutans and oral microcosm, respectively, p = 0.01). This makes CNCs particularly interesting as anticaries agents, encouraging their use in the oral field.
Extracellular Vesicle-Related Non-Coding RNAs in Hepatocellular Carcinoma: An Overview
Authors: Augello Giuseppa , Cusimano Alessandra , Cervello Melchiorre , Cusimano Antonella
Published: April 2024

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is a major public health problem worldwide, and it is often diagnosed at advanced stages, when no effective treatment options are available. Extracellular vesicles (EVs) are nanosized double-layer lipid vesicles containing various biomolecule cargoes, such as lipids, proteins, and nucleic acids. EVs are released from nearly all types of cells and have been shown to play an important role in cell-to-cell communication. In recent years, many studies have investigated the role of EVs in cancer, including HCC. Emerging studies have shown that EVs play primary roles in the development and progression of cancer, modulating tumor growth and metastasis formation. Moreover, it has been observed that non-coding RNAs (ncRNAs) carried by tumor cell-derived EVs promote tumorigenesis, regulating the tumor microenvironment (TME) and playing critical roles in the progression, angiogenesis, metastasis, immune escape, and drug resistance of HCC. EV-related ncRNAs can provide information regarding disease status, thus encompassing a role as biomarkers. In this review, we discuss the main roles of ncRNAs present in HCC-derived EVs, including micro(mi) RNAs, long non-coding (lnc) RNAs, and circular (circ) RNAs, and their potential clinical value as biomarkers and therapeutic targets.
Real-World Electronic Medical Records Data Identify Risk Factors for Myelofibrosis and Can Be Used to Validate Established Prognostic Scores
Authors: Kappenstein Max , von Bubnoff Nikolas
Published: April 2024

Myelofibrosis (MF) is a myeloproliferative neoplasia arising de novo as primary myelofibrosis (PMF) or secondary to polycythemia vera or essential thrombocythemia. Patients experience a high symptom burden and a marked reduction in life expectancy. Despite progress in molecular understanding and treatment, the clinical and prognostic heterogeneity of MF complicates treatment decisions. The International Prognostic Scoring System (IPSS) integrates clinical factors for risk stratification in MF. This study leverages the TriNetX database with more than 64,000 MF patients to assess the impact of accessible parameters on survival and complicating events, including AML transformation, cachexia, increased systemic inflammation, thrombosis and hemorrhage. Age over 65 years correlated with increased risks of death, AML transformation, thrombosis and hemorrhage. Anemia (Hb < 10 g/dL), leukocytosis (>25 × 103/µL) and thrombocytopenia (<150 × 103/µL) reduced survival and increased risks across all assessed events. Monocytosis is associated with decreased survival, whereas eosinophilia and basophilia were linked to improved survival. Further, as proof of concept for the applicability of TriNetX for clinical scores, we devised a simplified IPSS, and confirmed its value in predicting outcomes. This comprehensive study underscores the importance of age, anemia, leukocytosis and thrombocytopenia in predicting disease trajectory and contributes to refining prognostic models, addressing the challenges posed by the disease’s heterogeneity.
The Use of Non-Prescribed Medicines in Infants from Birth to Six Months in Rural Areas of Polokwane Municipality—Limpopo Province, South Africa
Authors: Makwela Maishataba Solomon , Maimela Eric , Bopape Makoma Melicca , Mashaba Reneilwe Given
Published: April 2024

The WHO and UNICEF recommend that only breastmilk, vitamin drops, oral rehydration solution, and prescribed medicine can go through the infant’s mouth. Non-prescribed medications (NPM) include over-the-counter medications and traditional medicine and are contraindicated during infancy. Furthermore, the updated exclusive breastfeeding (EBF) indicator details that herbal fluids and similar traditional medicines are counted as fluids, and infants who consume these are not exclusively breastfed. However, the use of these items is common among caregivers for various reasons, including religious reasons, cultural beliefs, prevention of diseases, and the treatment of diseases. The practice of administering NPM before six months of age undermines exclusive breastfeeding and can result in undesirable health outcomes. Methods: The purpose of this study was to determine the prevalence of NPM, describe the types of medications used, and explain why caregivers use NMP in infants younger than six months of age. A quantitative approach and a facility-based cross-sectional survey were used to conduct this study. Convenience sampling was used to select clinics, and proportionality and simple random sampling were used to select 146 participants. Data were analyzed using SPSS (29). A p-value of p < 0.05 was considered significant. Results: In this study, the prevalence of NPM was 75.3%. Of the 146 participants, most were 25–35 years old (54%) and first-time mothers (36.3%). More caregivers had high school and matric (67.1%), and 84.2% of caregivers delivered in public health facilities. Almost three-quarters are unemployed (66.7%) and on a child support grant (56.4%). About 43.6% of infants received NPM within the first month of life. The main source of advice to give NPM was family members (86.4%). The main reasons for administering NPM were the treatment of the umbilical cord (57.3%) and the prevention of colic (32.7%). The results show a statistically significant association between the administration of medication and the age of the infant, p < 0.005. Conclusions: Non-prescribed medications are highly prevalent in the rural areas of Polokwane and are practiced by caregivers between the ages of 25–35 years advised by the families. Access to self-medication should be controlled, especially in the first month of life. Interventions to reduce the use of NPM should be targeted at young mothers and their families.
True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations—Brief Report
Authors: Hoffmann Michèle , Banz Yara , Halter Jörg , Schoumans Jacqueline , Tchinda Joëlle , Bacher Ulrike , Pabst Thomas
Published: April 2024

Donor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL’s clinical challenge lies in its late onset. Its origin is affected by donor cell anomalies, transplant environment, and additional mutations. A 43-year-old woman, treated for early stage triple-negative breast cancer, developed mixed-phenotype acute leukemia (MPAL), 12 years later. Following induction chemotherapy, myeloablative conditioning, and allo-HSCT from her fully HLA-matched brother, she exhibited multiple cutaneous relapses of the original leukemia, subsequently evolving into DCL of the bone marrow. Cytogenetic analysis revealed a complex male karyotype in 20 out of 21 metaphases, however, still showing the MPAL phenotype. DCL diagnosis was confirmed by 90.5% XY in FISH analysis and the male karyotype. Declining further intensive chemotherapy including a second allo-HSCT, she was subsequently treated with repeated radiotherapy, palliative systemic therapies, and finally venetoclax and navitoclax but died seven months post-DCL diagnosis. This case underlines DCL’s complexity, characterized by unique genetics, further complicating diagnosis. It highlights the need for advanced diagnostic techniques for DCL identification and underscores the urgency for early detection and better prevention and treatment strategies.
Hygrothermal Performance of the Hemp Concrete Building Envelope
Authors: Kaboré Aguerata , Maref Wahid , Ouellet-Plamondon Claudiane M.
Published: April 2024

The search for environmentally friendly and low-carbon-footprint construction materials continues progressively. Researchers are now interested in innovative materials that connect with the principles of sustainable construction, and materials such as hemp concrete prove to be promising. This article presents the results of a study that aimed to evaluate the hygrothermal performance of hemp concrete integrated into the building envelope using the hygrothermal tool WUFI Pro 6.2. The simulation model was compared and verified with existing models before its utilization for this study. The results of this verification were in good agreement, which gave us more confidence in its application for further parametric studies of building envelopes in hot climate zones. Three wall systems were simulated: (i) a wall system with hemp concrete, (ii) a compressed earth block wall, and (iii) a cement block wall. The most important variables used in the simulations were the hygrothermal properties of the materials or wall components and the incident solar radiation. The simulation results showed that hemp concrete has good thermal performance and temperature and humidity regulation capabilities of the building envelope. The interior surface temperatures of the hemp concrete walls were between 22.1 °C and 24.6 °C compared to the compressed earth block and cement block walls, where the surface temperatures were between 22.0 °C and 27 °C and between 21.2 °C and 28.7 °C, respectively, and between 23 °C and 45 °C for the exterior temperatures. These values remain the same with the increase in exterior temperatures for hemp concrete walls. In conclusion, hemp concrete could be a great alternative material for use in construction for hot climate zones.
Auditing and Analysis of Natural Gas Consumptions in Small- and Medium-Sized Industrial Facilities in the Greater Toronto Area for Energy Conservation Opportunities
Authors: Baig Altamash Ahmad , Fung Alan S. , Kumar Rakesh
Published: April 2024

This paper presents the findings of fifteen energy audits conducted on industrial sites in Canada’s Greater Toronto Area (GTA). The audits covered a range of industries including food processing, packaged goods, and finishing processes (powder-coating). The primary focus of the audits was to analyze the natural gas consumption and the performance of major-gas-consuming equipment. The audits identified natural-gas-consuming equipment that could be optimized to yield energy and operational cost savings and greenhouse gas (GHG) reduction opportunities. Food production plants’ energy intensity ranges from 5.59 m3/ft2 to 17.73 m3/ft2. Therefore, there is a significant opportunity to improve energy consumption through better technology integration. The results of the audits indicate a trend of an increase in the percentage of non-productive consumption with non-productive time. The proposed energy-saving measures include reducing non-productive natural gas consumption, gas-fired equipment tune-up, optimizing boiler loads, and reducing oven exhaust by using variable frequency drives (VFDs). The findings of this study could be used to develop a demand-side management program specifically for small- and medium-sized industrial facilities in the Greater Toronto Area and other parts of Canada.
Detonation Cell Size Prediction Using Artificial Neural Networks (ANNs) for Hydrogen/Hydrocarbon/Ammonia/Nitrous Oxide Mixtures
Authors: Bakalis Georgios , Ng Hoi Dick
Published: April 2024

In this work, a previously developed three-feature Artificial Neural Network (ANN) model with dimensional inputs is directly applied to predict the cell size of hydrocarbon/ammonia/nitrous oxide mixtures and compare these to experimental data. This model uses as inputs three ZND parameters (MCJ, ΔI, and σ˙max), which are mainly calculated using Konnov’s and Mével’s mechanisms. A similar prediction is obtained with the two mechanisms for the biogas–O2, H2–O2, H2–N2O, and NH3–O2 mixtures, indicating that the model is not only limited to Konnov’s chemical kinetic mechanism which was used for its training. The overall good agreement between the ANN predictions and the actual experimental values for the aforementioned mixtures, which are not used in the original training of the ANN model, is promising and shows its potential for application and extension to other mixtures and initial conditions, provided that the chemical kinetic parameters describing the ideal reaction zone structure could be computed. The model is then used to compare experimental cell size data from two detonation tube facilities, and also different chemical kinetic mechanisms for NH3-N2O mixtures. In the end, the original ANN model is expanded with the inclusion of additional cell size data, showing a slightly lower mean error for the predicted cell sizes if the data for the mixtures considered in this study are taken into account for the training of the new ANN model.
Discrete and Continuous Adjoint-Based Aerostructural Wing Shape Optimization of a Business Jet
Authors: Tsiakas Konstantinos , Trompoukis Xenofon , Asouti Varvara , Giannakoglou Kyriakos , Rogé Gilbert , Julisson Sarah , Martin Ludovic , Kleinveld Steven
Published: April 2024

This article presents single- and multi-disciplinary shape optimizations of a generic business jet wing at two transonic cruise flow conditions. The studies performed are based on two high-fidelity gradient-based optimization tools, assisted by the adjoint method (following both discrete and continuous approaches). Single discipline and coupled multi-disciplinary sensitivity derivatives computed from the two tools are compared and verified against finite differences. The importance of not making the frozen turbulence assumption in adjoint-based optimization is demonstrated. Then, a number of optimization runs, ranging from a pure aerodynamic with a rigid structure to an aerostructural one exploring the trade-offs between the involved disciplines, are presented and discussed. The middle-ground scenario of optimizing the wing with aerodynamic criteria and, then, performing an aerostructural trimming is also investigated.
Detection of Pipeline Leaks Using Fractal Analysis of Acoustic Signals
Authors: Zagretdinov Ayrat , Ziganshin Shamil , Izmailova Eugenia , Vankov Yuri , Klyukin Ilya , Alexandrov Roman
Published: April 2024

In this paper, the possibility of using monofractal and multifractal analysis of acoustic signals of pipelines to detect leaks is considered. An experimental stand has been created to study the fractal characteristics of acoustic signals of pipelines with “slit” type defects. During the experiments, defects of the “slit” type pipeline with dimensions of 2 mm, 8 mm, and 20 mm were modeled. Detrended fluctuation analysis (DFA) and the multifractal detrended fluctuation analysis (MF-DFA) were used. As a result of the experimental studies, it was found that the occurrence of leakage leads to the occurrence of anticorrelated vibrations in a pipeline with multifractal properties. The analyses of acoustic signals by DFA and MF-DFA methods make it possible to reliably determine the leakage. The Hurst exponent and the width of the multifractal spectrum can serve as indicators of the occurrence of leaks in pipelines.
Characteristics of the Genetic Spread of Carbapenem-Resistant Acinetobacter baumannii in a Tertiary Greek Hospital
Authors: Papadopoulou Martha , Deliolanis Ioannis , Polemis Michalis , Vatopoulos Alkiviadis , Psichogiou Mina , Giakkoupi Panagiota
Published: April 2024

Acinetobacter baumannii (Ab) has increasingly been identified as a cause of hospital-acquired infections and epidemics. The rise of carbapenem-resistant Acinetobacter baumannii (CRAB) poses significant challenges in treatment. Nosocomial outbreaks linked to CRAΒ A. baumannii strains have been reported worldwide, including in Greece. This study aimed to analyze the molecular epidemiology trends of multidrug-resistant A. baumannii isolates in a tertiary hospital in Athens, Greece. A total of 43 clinical isolates of extensively drug-resistant (XDRAB), pan-drug-resistant (PDRAB), and CRAB were collected from patients suffering from blood infection, hospitalized between 2016 and 2020 at the internal medicine clinics and the ICU. A.baumannii isolates underwent testing for Ambler class B and D carbapenemases and the detection of ISAba1, and were typed, initially, using pulsed-field gel electrophoresis, and, subsequently, using sequence-based typing and multiplex PCR to determine European Clone lineages. The blaOXA-23 gene accompanied by ISAba1 was prevalent in nearly all A. baumannii isolates, except for one carrying blaOXA-58. The intrinsic blaOXA-51-like gene was found in all isolates. No Ambler class B carbapenemases (VIM, NDM) were detected. Isolates were grouped into four PF-clusters and no one-cluster spread was documented, consistent with the absence of outbreak. The study indicated that XDR/PDR-CRAB isolates predominantly produce OXA-23 carbapenemase and belong to European Clone II. Further research is needed to understand the distribution of resistant bacteria and develop effective prevention and control strategies.
X-ray Synchrotron Radiation to Look at Pigments in Antiquities: Overview and Examples
Authors: Gianoncelli Alessandra , Schöder Sebastian , Plaisier Jasper R. , Fugazzotto Maura , Barone Germana , Russo Alfonsina , Mazzoleni Paolo , Raneri Simona
Published: April 2024

The recent upgrading of synchrotron radiation (SR) sources has favored, in the last few years, the construction and design of beamlines optimized for the study of cultural heritage materials, which may require ad hoc setups, specific spatial resolutions, and detection limits. In the field of cultural heritage, integrated approaches combining different techniques are often required, even at large facilities, where some beamlines offer the possibility of performing different types of measurements at the same point of analysis, complementing preliminary information usually obtained by conventional laboratory and/or portable in situ methods. An overview of the last ten years of synchrotron applications for the study of pigments is given, with discussion of upstream and downstream challenges to methods and techniques. The possibilities offered by the synchrotron techniques are illustrated by a case study of a particular class of painted ceramics, as an example of different research questions that are solved by a combination of SR-based methods.
Mandarin Variety Significantly Affects the Metabolites Present in the Leaves
Authors: Maciá-Vázquez Alejandro Andy , Núñez-Gómez Dámaris , Martínez-Nicolás Juan José , Legua Pilar , Melgarejo Pablo
Published: April 2024

Late-season varieties of mandarin (Citrus reticulata Blanco) have a high economic value, so their study, characterization, and comparison among different commercial varieties is of great interest for agriculture. Detailed metabolomic analysis of mandarin leaves can provide valuable information on agronomic characteristics, vegetative development, and tree response to abiotic and biotic stresses. In this study, an analysis of the main metabolites presents in the leaves of three late-season mandarin orange varieties (‘Afourer’, ‘Orri’ and ‘Tango’), cultivated under homogeneous conditions, was carried out using nuclear magnetic resonance (1H NMR) and multivariate statistical analysis techniques. The results show that organic acids and sugars are the metabolites with the highest presence in mandarin leaves, especially malate and sucrose. Ten amino acids and other metabolites such as choline and trigonelline were also detected. Metabolites such as asparagine and isoleucine were widely implicated in the metabolic pathways of the detected compounds. The ‘Orri’ variety showed significantly more differences in metabolite concentrations compared to the other two varieties studied. Malate and sucrose were shown to be the metabolites with the greatest significant differences between the varieties compared. From an agronomic point of view, the ‘Orri’ variety differs from the other two varieties because it has concentrations of metabolites that provide good resistance to abiotic and biotic stresses and fruits of higher quality and sweetness.
Signaling of Plant Defense Mediated by Receptor-like Kinases, Receptor-like Cytoplasmic Protein Kinases and MAPKs Triggered by Fungal Chitin in Horticultural Crops
Authors: Reyes Zamora Orlando , Troncoso-Rojas Rosalba , Báez-Flores María Elena , Tiznado-Hernández Martín Ernesto , Rascón-Chu Agustín
Published: April 2024

Fresh horticultural products are economically significant foods that are highly demanded by consumers worldwide; however, they are highly perishable and susceptible to deterioration by fungi, which contribute to their short shelf-life and cause significant post-harvest losses. Among the alternatives suggested for fungal control in plants is the elicitation of the innate plant defense mechanism, which may be activated when specific molecules of the phytopathogen, such as chitin, are recognized. Chitin is a long-chain polymer of N-acetyl-α-D-glucosamine of the fungal cell wall; it possesses biological activity by eliciting the plant immune response. This molecule and its oligosaccharides are recognized through transmembrane receptors known as receptor-like kinases (RLKs) and receptor-like proteins (RLPs). Mediated by receptor-like cytoplasmic kinases (RLCKs), which bind to the intracellular domain of these receptors, they initiate intracellular signal transduction via MAP kinases, triggering the plant defense response. In model plants, such as Oryza sativa (rice) and Arabidopsis thaliana, the set of RLK/RLP-RLCK-MAP kinases is involved in plant immunity triggered by chitin. Furthermore, in horticultural products, research into the molecular events between these three elements has suggested that similar processes occur. However, little is known about these molecular events in fruits. Against this background, the present review provides the most recent and relevant findings on the molecular associations of these three elements in the response to fungal chitin in plants and outlines which elements could participate in this signaling process in horticultural crops.