bluuebunny/crossref_metadata_2025 huggingface dataset:
Simple Direction-of-Arrival Estimation under Nonuniform Noise Scenarios
Authors: Sun Fenggang , Wu Jiefang , Fan Hao , Chen Lizhen , Lan Peng
Published: May 2022

The uniform white noise assumption is widely applied for most of the existing direction-of-arrival (DOA) estimation methods, which however may degrade the estimation performance. In practical scenarios, the nonuniform white noise model is more adequate. In this paper, we propose a simple DOA estimation method in the presence of spatially nonuniform white noise with unknown noise covariance matrix. The estimate of the unknown noise covariance matrix is firstly obtained by utilizing the shift property of identical subarrays. Then, the received signal covariance matrix is prewhitened by the estimated noise covariance, which can overcome the biased estimate of signal covariance. Finally, the performance improvement is verified by simulations in terms of resolution ability and estimation accuracy.
Network Pharmacology and In Vivo Analysis of Dahuang-Huangqi Decoction Effectiveness in Alleviating Renal Interstitial Fibrosis
Authors: Luo Yan , Xuan Chen , Cheng Junxiong , Xiong Yu , Cao Wenfu
Published: May 2022

Dahuang and Huangqi are the most frequently prescribed treatment methods for chronic kidney disease in China. Our study aimed to clarify the pharmacological mechanism of action of Dahuang-Huangqi decoction (DHHQD) in renal interstitial fibrosis (RIF). The intersection of genes targeted by DHHQD active ingredients and RIF target genes was searched using network pharmacology to build a chemical ingredient and disease target network. For in vivo analysis, Sprague–Dawley rats with unilateral urethral obstruction (UUO) were administered DHHQD, and their kidney function-related indicators and pathological indices were determined. The expression of core targets was quantified using real-time polymerase chain reaction and western blotting. A total of 139 common targets for DHHQD and RIF in chronic kidney disease were detected. Compared with the untreated UUO rats, the DHHQD-treated rats showed reductions in the following: blood urea nitrogen and serum creatinine levels, kidney tubular atrophy and necrosis, interstitial fibrosis, hyperplasia and abnormal deposition of extracellular matrix, and microstructural changes in the mesangial matrix and glomerular basement membrane. DHHQD treatment significantly regulated the levels of renal core proteins, such as eNOS, IL-6, EGFR, and VEGF and reduced the mRNA and protein expression of the core targets involved in inflammation pathways, such as PI3K/AKT and TLR4/NF-κB. DHHQD treatment ameliorated the severity of RIF by potentially regulating the AKT/PI3K and TLR4/NF-κB signaling pathways. Our study findings provide insights into the mechanisms associated with DHHQD action and essential data for future research.
Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3
Authors: Luo Xiaohua , Pan Ci , Guo Xiaopei , Gu Cunhua , Huang Yulian , Guo Jing , Zeng Ying , Yue Jinjing , Cui Shihong
Published: May 2022

Preeclampsia (PE) is a common pregnancy-related syndrome characterized by chronic immune activation. This study is aimed at exploring the role of miR-155 in the inflammatory pathogenesis of PE. Placental tissues and peripheral blood were collected from all subjects. BSP detection analysis was performed to evaluate miR-155 methylation levels. ELISA was performed to measure the levels of inflammatory cytokines and MMP2 in serum samples and cellular supernatants. HTR-8/SVneo and JEG-3 cells were transfected with miR-155 mimic and the inhibitor to establish the overexpressed miR-155 and silenced miR-155 cell models, respectively. Treatment with 5-Aza was performed to alter the DNA methylation level of miR-155. The PE rat model was established after subcutaneous injection of NG-nitro-L-arginine methyl ester. The CCK-8 assay, TUNEL staining, and Transwell assay were performed. Reverse transcription-quantitative PCR, Western blot analysis, and immunohistochemical assay were used to analyze related gene expression levels. The luciferase reporter assay was used to investigate the direct interaction between FOXO3 and miR-155. Results showed that miR-155 was remarkably upregulated and inversely correlated with the promoter methylation level in the placental tissue from PE patients. The in vitro experiments indicated that miR-155 decreased viability, migration, and invasion, but increased apoptosis in trophoblast cells. FOXO3 was confirmed as the target of miR-155. Transfection of the miR-155 inhibitor suppressed inflammation and oxidative stress, but elevated proliferation, migration, and invasion of trophoblast cells, which were abolished by 5-Aza treatment or cotransfection with si-FOXO3. In summary, our data suggested that methylation-mediated silencing of miR-155 can inhibit the apoptosis, inflammation, and oxidative stress of trophoblast cells by upregulating FOXO3.
Intelligent Control of a Driverless Energy Vehicle Based on an Environment Sensing Sensor
Authors: Xue Yuanfei , Lou Zhijiang
Published: May 2022

In order to solve the complex environment in the process of vehicle driving and the complexity of self-vehicle structure, intelligent vehicles are prone to rear end collision, lateral collision, and other safety accidents in the presence of tall trees, mountains, and other road environments, endangering the safety of people on board. According to parameters such as the speed of the vehicle, the movement of the blind spot, and the relationship between the vehicle and the blind spot, the model is based on the safety mode of the preceding vehicle. Based on the static obstacles that may exist in the sensing blind area, a sensor sensing blind area safety distance model is established. Based on the possible dynamic obstacles, the active collision avoidance algorithm based on the sensor perceived blind area is studied and simulated. The experimental results show that the selected sensor sensing blind area active collision avoidance controller can well adapt to a variety of special and emergency working conditions, can accurately complete the accurate control of sensor sensing blind area active collision avoidance, and avoid collision accidents to the greatest extent. Compared with the control group, the system designed in this paper can avoid more than 80% of the collision scenes compared with the previous anticollision system. It provides a reference for the future research of sensor sensing blind area-related topics and sensor sensing blind area active collision avoidance system. To a certain extent, it can improve the ability of intelligent vehicle environmental perception and reduce the incidence of rear end collision accidents.
Cooling a Hot Semiannulus with Constant Heat Flux by Using Fe3O4‐Water Nanofluid and a Magnetic Field: Natural Convection Mechanism
Authors: Yang Zhengqiang , Bouzgarrou S. M. , Marzouki Riadh , Aouaini Fatma , El-Shorbagy M. A. , Dahari Mahidzal , Shah Said Anwar , Suthar D. L.
Published: May 2022

In this simulation, the nanoparticle distribution and entropy generation were studied using the Buongiorno’s developed two‐phase model and magnetic field inside a porous semiannulus cavity. The influence of three terms was considered in the Buongiorno’s developed two‐phase model such as Brownian motion, thermophoresis, and magnetophoresis effects. In addition, the entropy generation was assessed due to temperature and velocity gradient. The evidence showed that the effects of the magnetic field in high porosities and volume fraction of nanoparticles were remarkable on the Nusselt number and entropy generation. Also, irreversibility due to heat transfer is much greater than fluid friction.
Prevalence of Refractive Error in School Children in Suining City of Sichuan Province, China: A School-Based Cross-Sectional Study
Authors: Liu Linglin , Li Heng , Tang Zhijin , Huang Zaihong , Yang Xu
Published: May 2022

Objective. To investigate the prevalence of refractive errors among school children in Suining City, Sichuan Province, and to provide a scientific basis for prevention and control of myopia. Methods. This was a school-based cross-sectional study. Children aged 6-15 years were selected from kindergartens, primary schools, and middle schools in the urban setting of Suining City. The children underwent ocular examination including measurement of uncorrected visual acuity (UCVA), visual acuity when wearing glasses, and noncycloplegic autorefractometry. Results. Of the 1200 eligible students, 1138 children (94.8%), 553 of them girls (47.4%), participated. The mean age was

10.64
±
2.89

years. The prevalence of myopia, hyperopia, astigmatism, and emmetropia was 59.1% (95% confidence interval (CI): 57.6, 60.5), 5.0% (95% CI: 4.7, 6.1), 38.4% (95% CI: 55.5, 58.5), and 25% (95% CI: 23.7, 26.2), respectively. In univariate analysis, the prevalence of myopia was correlated with age, female gender, and learning stage. The prevalence of hyperopia and astigmatism was correlated with age and learning stage. The prevalence of mild myopia, moderate myopia, and high myopia in the 1138 students was 17.7%, 41.4%, and 3.3%, respectively. The prevalence of mild, moderate, and high myopia all increased with age and learning stage. The prevalence of myopia differed by gender. The mean spherical equivalents of the right and left eyes were

−
1.40
±
1.99

diopters (D) and

−
1.29
±
1.93
 
D

, respectively, and the median values were -0.75 D and -0.6 D, respectively. The mean spherical equivalent increased with age, learning stage, and female gender. Conclusions. The most common type of refractive error was myopia which was associated with higher age, female gender, and higher learning stage. This study provides new data and recommendations for myopia-control in school-aged children in Sichuan province.
Wood Quality Defect Detection Based on Deep Learning and Multicriteria Framework
Authors: Sun Ping’an
Published: May 2022

Traditional nondestructive testing technology for wood defects has a series of problems such as low identification accuracy, high cost, and cumbersome operation, and traditional testing methods cannot accurately show the specific location and size of wood internal defects; it is urgent to explore a new nondestructive testing scheme for wood defects. Aiming at this problem, this paper designs and develops an automatic detection method for wood surface defects based on deep learning algorithm and multicriteria framework. By comparing the performance of different deep learning detection methods on the data set, the advantages and disadvantages of the detection method in this paper are proved. After a series of works, such as the development and optimization of the experimental algorithm, the algorithm proposed meets the requirements in both the detection accuracy and training time.
The Feasibility of Percutaneous Dilatational Tracheostomy in Immunosuppressed ICU Patients with or without Thrombocytopenia
Authors: Angelberger Marianne , Barnikel Michaela , Fraccaroli Alessia , Tischer Johanna , Antón Sofía , Pawlikowski Alexandra , op den Winkel Mark , Stemmler Hans Joachim , Stecher Stephanie-Susanne
Published: May 2022

Background. Percutaneous dilatational tracheostomy (PDT) has become the preferred method in several intensive care units (ICUs), but data on PDT performed in immunosuppressed and thrombocytopenic patients are scarce. This study aimed to analyze the feasibility of PDT in immunosuppressed and thrombocytopenic patients compared to conventional open surgical tracheostomy (OST). Methods. We retrospectively analyzed the charts of patients who underwent PDT or OST between May 2017 and November 2020. Our outcomes were stoma site infections and bleeding complications. Results. 63 patients underwent PDT, and 21 patients underwent OST. Distribution of gender ratio, age, SAPS II, time of ventilation before tracheostomy, and preexisting hematooncological diseases was comparable between the two groups. After allogeneic stem cell transplantation (alloSCT), patients were more likely to undergo PDT than OST (

p
=
0.033

). The PDT cohort suffered from mucositis more frequently (

p
=
0.043

). There were no significant differences in leucocyte or platelet count on the tracheostomy day. Patients with coagulation disorders and patients under immunosuppression were distributed equally among both groups. Stoma site infection was documented in five cases in PDT and eight cases in the OST group. Moderate infections were remarkably increased in the OST group. Smears were positive in six cases in the PDT group; none of these patients had local infection signs. In the OST group, smears were positive in four cases; all had signs of a stroma site infection. Postprocedural bleedings occurred in eight cases (9.5%) and were observed significantly more often in the OST group (

p
=
0.001

), leading to emergency surgery in one case of the OST group. Conclusion. PDT is a feasible and safe procedure in a predominantly immunosuppressed and thrombocytopenic patient cohort without an increased risk for stoma site infections or bleeding complications.
A Multiobjective Multiproduct Mathematical Modeling for Green Supply Chain considering Location-Routing Decisions
Authors: Zarean Dowlat Abadi Javad , Iraj Mohammad , Bagheri Ensieh , RabieiPakdeh Zeynab , Dehghani Tafti Mohammad Reza
Published: May 2022

Global warming and environmental pollution are concepts that are more or less encountered in the news and newspapers today. Protecting the environment is crucial to the survival of humanity and the many plant and animal species that inhabit the planet. Lack of control of greenhouse gases can increase the average surface temperature and lead to floods and serious damage in the near future. On the other hand, overproduction of plastics by factories can lead to environmental pollution and the destruction of many food cycles on Earth. In this study, in order to sustainability integrate issues in supply chain network design decisions, a multiobjective optimization model is presented, which is a two-level routing location problem and optimizes economic and environmental goals. The first level is decisions related to the selection of operating facilities from a set of potential facilities (manufacturers and distribution centers), and the second level is related to determining the number of products from distribution centers to retailers and from manufacturers to distribution centers. The objective function is also of the minimization type, which is related to minimizing fixed and variable costs, and minimizing the environmental effects of the whole chain, which includes reducing the costs of greenhouse gas and carbon emissions.
Chronic Oral Anticoagulation Therapy and Prognosis of Patients Admitted to Hospital for COVID-19: Insights from the HOPE COVID-19 Registry
Authors: Rivera-Caravaca José Miguel , Núñez-Gil Iván J. , Lip Gregory Y. H. , Uribarri Aitor , Viana-Llamas María C. , Gonzalez Adelina , Castro-Mejía Alex F. , Alonso González Berta , Alfonso Emilio , García Prieto Juan Fortunato , Cavallino Chiara , Cortese Bernardo , Feltes Gisela , Fernández-Rozas Inmaculada , Signes-Costa Jaime , Huang Jia , García Aguado Marcos , Pepe Martino , Romero Rodolfo , Cerrato Enrico , Becerra-Muñoz Víctor Manuel , Raposeiras Roubin Sergio , Santoro Francesco , Bagur Rodrigo , Sposato Luciano , El-Battrawy Ibrahim , López Masjuan Alvaro , Fernandez-Ortiz Antonio , Estrada Vicente , Macaya Carlos , Marín Francisco
Published: May 2022

Background. Most evidence regarding anticoagulation and COVID-19 refers to the hospitalization setting, but the role of oral anticoagulation (OAC) before hospital admission has not been well explored. We compared clinical outcomes and short-term prognosis between patients with and without prior OAC therapy who were hospitalized for COVID-19. Methods. Analysis of the whole cohort of the HOPE COVID-19 Registry which included patients discharged (deceased or alive) after hospital admission for COVID-19 in 9 countries. All-cause mortality was the primary endpoint. Study outcomes were compared after adjusting variables using propensity score matching (PSM) analyses. Results. 7698 patients were suitable for the present analysis (675 (8.8%) on OAC at admission: 427 (5.6%) on VKAs and 248 (3.2%) on DOACs). After PSM, 1276 patients were analyzed (638 with OAC; 638 without OAC), without significant differences regarding the risk of thromboembolic events (OR 1.11, 95% CI 0.59–2.08). The risk of clinically relevant bleeding (OR 3.04, 95% CI 1.92–4.83), as well as the risk of mortality (HR 1.22, 95% CI 1.01–1.47; log-rank

p

value = 0.041), was significantly increased in previous OAC users. Amongst patients on prior OAC only, there were no differences in the risk of clinically relevant bleeding, thromboembolic events, or mortality when comparing previous VKA or DOAC users, after PSM. Conclusion. Hospitalized COVID-19 patients on prior OAC therapy had a higher risk of mortality and worse clinical outcomes compared to patients without prior OAC therapy, even after adjusting for comorbidities using a PSM. There were no differences in clinical outcomes in patients previously taking VKAs or DOACs. This trial is registered with NCT04334291/EUPAS34399.
C ∗‐Algebra‐Valued Extended Rectangular Hb‐Metric Spaces and Presić‐Type Fixed Point Theorem with an Application
Authors: Kohi Madjid , Hosseinzadeh Hasan , Abazari Rasoul , Bagheri Ali , Parvaneh Vahid
Published: May 2022

In this article, we introduce the concept of C ∗‐algebra‐valued extended rectangular Hb‐metric spaces and use it to prove the Banach contraction principle (BCP). Also, we extend this concept to Presić type contractions and use a method to shorten the proof. We also take an application to show the usefulness of our main result.
Asymptotics of m‐Cliques in a Sparse Inhomogeneous Random Graph
Authors: Zhao Xiaofeng
Published: May 2022

One of the classical questions in random graph theory is to understand the asymptotics of subgraph counts. In inhomogeneous random graph, this question has not been well studied. In this study, we investigate the asymptotic distribution of m‐cliques in a sparse inhomogeneous random graph. Under mild conditions, we prove that the number of m‐cliques converges in law to the standard normal distribution.
Numerical Solution of the Absolute Value Equations Using Two Matrix Splitting Fixed Point Iteration Methods
Authors: Ali Rashid , Ali Asad , Alam Mohammad Mahtab , Mohamed Abdullah
Published: May 2022

The absolute value equations (AVEs) are significant nonlinear and non-differentiable problems that arise in the optimization community. In this article, we provide two new iteration methods for determining AVEs. These two approaches are based on the fixed point principle and splitting of the coefficient matrix with three extra parameters. The convergence of these procedures is also presented using some theorems. The validity of our methodologies is demonstrated via numerical examples.
[Retracted] Securitization Concept and Its Application to Environmental Problems in the Kurdistan Region: Prospects and Obstacles
Authors: Abdulrahman Salam Abdulqadir , Evcan Nusret Sinan
Published: May 2022

Environmental pollution has caused a wide range of problems across the globe. Various studies have focused on worldwide water and environmental issues and their effects on human health and political and social aspects. This article, on the other hand, discusses soil, water, and air pollution as well as the overuse of water resources. This study then discusses these problems as a security issue in the Kurdistan Region of Iraq (KRI) context. This research adopts a qualitative approach. It reviews the results of previous studies on soil, water, and air pollution in KRI to demonstrate the causes and scale of the problem. It then explores securitization by looking at the main components of the concept and how they can be applied and what needs to be adjusted. Results of the study have shown that pollution is widespread, water is overexploited, and there is a lack of an effective response by the Kurdistan Regional Government (KRG). In addition, in the KRI context, securitization is state‐centered, meaning that the country’s decision‐makers play an important role in securitizing issues. The Kurdistan Regional Government, that is, the securitizing actor, should do more on the speech act, and this should be preceded by substantial political, economic, and psychological changes. Finally, the government must also enforce strict water control to support its water policies.
[Retracted] Identification of a Ferroptosis‐Related Prognostic Signature in Sepsis via Bioinformatics Analyses and Experiment Validation
Authors: Zhu Sizhe , Huang Yabing , Ye Chenglin
Published: May 2022

Ferroptosis is a new type of programmed cell death that is different from apoptosis, cell necrosis, and autophagy, which might be involved in development of sepsis. However, the potential role of ferroptosis‐related genes (FRGs) in sepsis remained unclear. We identified 41 ferroptosis‐related differential expression genes by weighted correlation network and differential expression analysis. The hub module of 41 ferroptosis‐related differential expression genes in the protein‐protein interaction network was identified. Next, we estimated diagnostic values of genes in hub modules. TLR4, WIPI1, and GABARAPL2 with high diagnostic value were selected for construction of risk prognostic model. The high risk‐scored patients had significantly higher mortality than the patients with low risk scores in discovery dataset. Furthermore, the risk scores of nonsurvivor were higher than those of survivor in validation dataset. It suggested that risk score was significantly correlated to prognosis in sepsis. Then, we constructed a nomogram for improving the clinical applicability of risk signature. Moreover, the risk score was significantly associated with immune infiltration in sepsis. Our comprehensive analysis of FRGs in sepsis demonstrated the potential roles in diagnosis, prognosis, and immune infiltration. This work may benefit in understanding FRGs in sepsis and pave a new path for diagnosis and assessment of prognosis.
Quantitative Assessment of Posterior Maxillary Arch for Orthodontic Miniscrew Insertion Using Cone Beam Computed Tomography: A Cross-Sectional Analysis
Authors: Valizadeh Solmaz , Zafarmand A. Hamid , Hassan Yazdi Sara , Ghazizadeh Ahsaie Mitra
Published: May 2022

Background and Aim. The aim of this study is to assess the cortical bone thickness and interradicular distance between posterior maxillary teeth using cone beam computed tomography (CBCT). Methods and Materials. Cone beam computed tomography records of 35 patients (70 quadrants) from maxilla were evaluated. The images were analyzed using the NNT viewer software (version 23). The measurements were made on axial sections at 2, 4, 6, and 8 mm from CEJ. The optimal sites were defined in terms of mesiodistal palatal or buccal interradicular distance, alveolar cortical bone thickness, and palatal or buccal safe depth of the bone for miniscrew insertion. Descriptive statistics, paired t-test, and repeated measure ANOVA were used to analyze the data. Results. The mean buccal interradicular distance was the lowest between first and second molar (2.44 mm) and the highest between first and second premolar (3.28 mm). The mean palatal interradicular distance was the lowest between first and second premolar (3.64 mm) and the highest between second premolar and first molar (5.30 mm). The mean buccal safe depth was the lowest between canine and first premolar (1.96 mm) and the highest between first and second molar (2.61 mm). The mean palatal safe depth was the lowest between second premolar and first molar (3.35 mm) and the highest between first and second molar (3.56 mm). The thinnest and thickest buccal cortical thicknesses were detected on canine and first molar (1.04 mm) and on the second premolar and second molar (1.56 mm). Conclusion. The quantity and quality of the maxillary alveolar process is an important factor to decide where to insert the orthodontic miniscrews, necessitating careful preoperative evaluation.
Intelligent Algorithm‐Based Magnetic Resonance for Evaluating the Effect of Platelet‐Rich Plasma in the Treatment of Intractable Pain of Knee Arthritis
Authors: Huang Bing , Huang Yun , Ma Xin , Chen Yuequn
Published: May 2022

The application of intelligent algorithms in the treatment of intractable pain of patients with platelet‐rich plasma (PRP) knee osteoarthritis by magnetic resonance was investigated. The automatic diagnosis of magnetic resonance knee osteoarthritis was established with multiple intelligent algorithms, including gray projection algorithm, adaptive binarization algorithm, and active shape model (ASM). The difference between automatic magnetic resonance detection indexes of the patients with knee osteoarthritis and artificial measurement results was analyzed. The included patients received PRP treatment. Knee osteoarthritis MRI osteoarthritis knee scores (KOA MOAKS) and Western Ontario and McMaster Universities arthritis index (WOMAC) before and after treatment were compared. The results showed that the results of knee osteoarthritis scores, inferior angle of femur, superior angle of tibia, and tibiofemoral angle (TFA) by automatic magnetic resonance diagnostic model were entirely consistent with artificial detection results. After the treatment, the total scores of knee lateral area, interior area, central area, and patellar area were all remarkably lower than those before the treatment (P < 0.05). After the treatment, knee KOA MOAKS scores and WOMAC scores were both lower than those before the treatment (P < 0.05). Visual analogue scale (VAS) scores 1 week, 2 weeks, and 3 weeks after the treatment were decreased compared with those before the treatment (P < 0.05). Relevant studies indicated that intelligent algorithm‐based automatic magnetic resonance diagnostic knee osteoarthritis model showed good utilization values, which could provide the reference and basis for the treatment of the patients with knee osteoarthritis.
Automatic Control System Design for Industrial Robots Based on Simulated Annealing and PID Algorithms
Authors: Zhu Yahong , Jiao Jian
Published: May 2022

The industry is at the heart of a country’s development, and robot automation is the key to this. The automation of industrial robots is extremely beneficial to industrial development. Although China has been increasing its investment in industrial robot automation and control research, there are still many problems in the field of automation and control in the application of industrial robot technology, and there is still a certain gap between the developed countries. On the one hand, this is a serious obstacle to the development of industrial robotics in China, and on the other hand, it has a direct impact on the automation of industrial production, which has a very restrictive effect on industrial development. Therefore, it is necessary to focus on the value of computer technology, automation control technology, and sensor technology in the field of automation. The use of industrial robots can replace monotonous manual labour, reduce the intensity of operations, and increase productivity through high operational precision values. Scientific progress has driven the development process of industrial automation to a new level, allowing fully automated production equipment to become mainstream and gradually replace manual operations. In recent years, the development of industrial automation has led to the development of a series of related industries, of which automated manipulators are one. As a new automatic production line operation equipment, the development of manipulators can greatly improve the automation production level of enterprises and improve labour efficiency. This paper explores the development status of automated manipulators and explore the optimal motion path of manipulators in automatic control engineering by combining simulated annealing algorithm and PID algorithm, so as to greatly enhance the application of truss manipulators in production lines.
[Retracted] Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism
Authors: Perumalsamy Haribalan , Shanmugam Rajeshkumar , Kim Jun-Ran , Anandapadmanaban Gokulanathan , Huq Md. Amdadul , Dua Kamal , Chellappan Dinesh Kumar , Yoon Tae Hyun , Balusamy Sri Renukadevi
Published: May 2022

Origanum vulgare essential oil (EO) is traditionally well‐known for its aromatic properties and biomedical applications, including anticancer. This was the first report where oregano essential oil‐based nano emulsion (OENE) was synthesized for studying its effects on prostate cancer cell lines (PC3). At first, we have synthesized OENE and characterized using various spectroscopic analyses. The toxicity and inhibitory concentration (IC50) of OENE toward prostate cancer by MTT analysis were performed. The lipid biogenesis mediated, molecular target pathway analyses were performed using fluorescence cellular staining techniques, real‐time RT‐PCR, or western blotting analysis. OENE showed IC50 at 13.82 µg/mL and significantly induced distinct morphological changes, including cell shrinkage, cell density, and cell shape reduction. In addition, OENE could also significantly decreased lipid droplet accumulation which was confirmed by studying mRNA transcripts of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) (0.31‐fold), fatty acid synthase (FASN) (0.18‐fold), and sterol regulatory element‐binding protein (SREPB1) (0.11‐fold), respectively. Furthermore, there is a significant upregulation BAX (BCL2 associated X) and caspase 3 expressions. Nevertheless, OENE decreased the transcript level of BCL2 (B‐cell lymphoma 2), thus resulting in apoptosis. Overall, our present work demonstrated that OENE could be a therapeutic target for the treatment of prostate cancer and warrants in vivo studies.
Structural and Functional Properties of Activator Protein-1 in Cancer and Inflammation
Authors: Bhosale Pritam Bhagwan , Kim Hun Hwan , Abusaliya Abuyaseer , Vetrivel Preethi , Ha Sang Eun , Park Min Yeong , Lee Ho Jeong , Kim Gon Sup
Published: May 2022

The transcriptional machinery is composed of numerous factors that help to regulate gene expression in cells. The function and the fundamental role of transcription factors in different human diseases and cancer have been extensively researched. Activator protein-1 (AP-1) is an inducible transcription factor that consists of a diverse group of members including Jun, Fos, Maf, and ATF. AP-1 involves a number of processes such as proliferation, migration, and survival in cells. Dysfunctional AP-1 activity is seen in several diseases, especially cancer and inflammatory disorders. The AP-1 proteins are controlled by mitogen-activated protein kinases (MAPKs) and the NF-κB pathway. AP-1 inhibitors can be actively pursued as drug discovery targets in cancer therapy when used as a treatment to halt tumor progression. The consumption of phytochemicals in the diet is related to decreasing the incidence of cancer and proves to exhibit anticancer properties. Natural product targets AP-1 are effective cancer prevention and treatment options for various cancer types. Targeting AP-1 with natural products is an effective cancer treatment option for different cancer types. This review summarizes AP-1 subunit proteins, their structures, AP-1-related signaling, and its modulation by natural bioactive compounds.
High School Education in a Variety of Regional Autonomy: Paradigm and Challenges
Authors: Indra Ristapawa , Ritonga Mahyudin , Kustati Martin , Rini Rini , Zulmuqim  , Rahmat Iswanto  , Gheisari Asma
Published: May 2022

This study combines heuristic and phenomenological approaches to analyze past phenomena regarding issues related to the implementation of school autonomy. A naturalistic approach regarding contemporary logical phenomena is used to see the practice of school autonomy after being returned to the provincial government. The main data sources of this study were school principals, teachers, school committee administrators, education leaders, and experts who were selected at random. The results of the study revealed that, in the early phase of regional autonomy, schools had flexible authority in managing the contribution of the provincial government; quality control through the results of the National Examination became the main requirement in determining graduation and became a source of pride for district/city governments. District/city governments compete fiercely in achieving the highest ranking through the implementation of the National Examination. This causes cheating to often become a debated issue among education observers and the public regarding the implementation of the National Examination. The research findings show that, since 2017, the issue of cheating on the National Examination is no longer a frightening specter because student graduation is no longer only determined by the National Examination.
Randomized, Double-Blind, Placebo-Controlled Phase III Study of Paclitaxel ± Napabucasin in Pretreated Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Authors: Shah Manish A. , Shitara Kohei , Lordick Florian , Bang Yung-Jue , Tebbutt Niall C. , Metges Jean-Phillippe , Muro Kei , Lee Keun-Wook , Shen Lin , Tjulandin Sergei , Hays John L. , Starling Naureen , Xu Rui-Hua , Sturtz Keren , Fontaine Marilyn , Oh Cindy , Brooks Emily M. , Xu Bo , Li Wei , Li Chiang J. , Borodyansky Laura , Van Cutsem Eric
Published: May 2022

Purpose:

To compare napabucasin (generator of reactive oxygen species) plus paclitaxel with paclitaxel only in patients with second-line advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma.

Patients and Methods:

In the double-blind, phase III BRIGHTER study (NCT02178956), patients were randomized (1:1) to napabucasin (480 mg orally twice daily) plus paclitaxel (80 mg/m2 i.v. weekly for 3 of 4 weeks) or placebo plus paclitaxel. The primary endpoint was overall survival (OS). Secondary endpoints included progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and safety.

Results:

Overall, 714 patients were randomized (napabucasin plus paclitaxel, n = 357; placebo plus paclitaxel, n = 357). 72.1% were male, 74.6% had gastric adenocarcinoma, and 46.2% had peritoneal metastases. The study was unblinded following an interim analysis at 380 deaths. The final efficacy analysis was performed on 565 deaths (median follow-up, 6.8 months). No significant differences were observed between napabucasin plus paclitaxel and placebo plus paclitaxel for OS (6.93 vs. 7.36 months), PFS (3.55 vs. 3.68 months), ORR (16% vs. 18%), or DCR (55% vs. 58%). Grade ≥3 adverse events occurred in 69.5% and 59.7% of patients administered napabucasin plus paclitaxel and placebo plus paclitaxel, respectively, with grade ≥3 diarrhea reported in 16.2% and 1.4%, respectively.

Conclusions:

Adding napabucasin to paclitaxel did not improve survival in patients with pretreated advanced gastric or GEJ adenocarcinoma. Consistent with previous reports, the safety profile of napabucasin was driven by manageable gastrointestinal events; grade ≥3 diarrhea occurred at a higher frequency with napabucasin plus paclitaxel versus placebo plus paclitaxel.
O Direito às origens: segredo e desigualdade no controle de informações sobre a identidade pessoal
Authors: Fonseca Claudia
Published: May 2022

Neste artigo, analiso a interação entre adotados adultos em busca de suas origens biológicas e as figuras de autoridade que detêm informações sobre essas origens. Retomo brevemente a história do segredo envolvido na adoção, para desembocar na nova Lei de Adoção brasileira, que garante aos adotados “acesso irrestrito” aos seus dossiês. Trago a narrativa de adotados contatados por meio de uma associação (em Porto Alegre, Brasil) sobre suas experiências frustradas de busca, assim como de funcionários do Juizado local. Partindo do pressuposto que a busca das origens encerra muitos dos problemas encontrados nas discussões sobre outros direitos fundamentais, demonstro ao longo do artigo que os direitos são politicamente construídos, que envolvem sujeitos vivendo num mundo relacional, e que sua implementação passa pela microfísica dos espaços administrativos.
Bons chefes, maus chefes, chefões: elementos de filosofia política ameríndia
Authors: Perrone-Moisés Beatriz
Published: May 2022

Este artigo estabelece um diálogo entre mitos ameríndios e o pensamento de Pierre Clastres. Tem por fio condutor figuras de chefes ameríndios presentes na reflexão da antropologia política americanista e na mitologia. Os mitos são aqui tomados como pensamento (cf. Lévi-Strauss), e embora o próprio Clastres opusesse por vezes mito e pensamento, mitos como os que são aqui analisados podem ser lidos como reforço à sua famosa tese da Sociedade contra o Estado. Tais mitos são aqui apresentados, ao lado de outras histórias, como elementos a serem acrescentados à imagem do “chefe sem poder” ameríndio – e introduzir-lhe certas modulações. Trata-se, finalmente, de defender a necessidade de prosseguir a “revolução copernicana” proposta por Clastres, não mais em prol de uma teoria geral da política (ou antropologia política, em seus termos), mas para buscar os termos ameríndios de conceber e praticar política, uma filosofia política ameríndia (antropologia política ameríndia?).
O profeta, a palavra e a circulação do carisma pentecostal
Authors: Campos Roberta Bivar Carneiro
Published: May 2022

Este artigo aborda o surgimento e a atuação de líderes carismáticos no pentecostalismo brasileiro que desafia a visão comum do papel do pastor protestante na mediação com Deus. Para além da transformação do pastor em celebridade, reflito sobre a forma de autoridade do carisma pentecostal, sua circulação e transmissão. Três direções em que o carisma circula serão destacadas: 1. sua comodificação através de cursos e conferências pagos, tornando-se evidente que é possível aprender a ser líder com os próprios líderes carismáticos; 2. o carisma, além de ser apreendido num espaço comercial e público, também é passado como capital social e simbólico através dos nomes de família do líder carismático, a exemplo das famílias Valadão, Soares, Malafaia e outras; 3. a autoridade do carisma depende de sua propagação coletiva, que se faz entre os pastores e os fiéis. Estes últimos, por sua vez, também mimetizam o carisma do líder, acessando esse capital e adquirindo o habitus carismático através não só da participação nos cultos, mas também do consumo. Além de reconhecer a produção social do carisma, faz-se necessário entender a sua circulação e o seu compartilhamento. Seguir a trilha do carisma é também seguir a maneira como a mensagem pentecostal circula e se globaliza.
“A gente é que sabe” ou sobre as coisas katukina (pano)
Authors: Lima Edilene Coffaci de
Published: May 2022

Neste artigo irei abordar as transformações em curso em tornodo kampô, a aplicação da secreção do sapo-verde, entre os Katukina. Interessam-me os efeitos sociológicos e conceituais que se processam entre osKatukina com a popularização do kampô no meio urbano e sua valorizaçãocomo um recurso genético da biodiversidade de particular interesse para aciência. Assim, serão apresentadas e discutidas as transformações que têminício com a popularização do kampô no meio urbano, os embates internose externos que surgem por causa delas e como afetam e interagem com asconcepções nativas sobre o que se entende como um conhecimento. Seguireineste esforço, entre outras coisas, buscando uma exegese do termo Nokehaweti, que tem sido corriqueiramente traduzido como “cultura”, e abordandoparte do vocabulário relativo às formas de aprender, no qual a audiçãoe a visão ocupam um lugar de destaque e aparecem estritamente associadas.Ao final, buscarei explorar as elaborações e interpretações própriasdos Katukina sobre a “perda”, palavra recorrente quando se discutem osconhecimentos tradicionais, o patrimônio material e imaterial e a valorizaçãocultural.
A pintura esquecida e o desenho roubado: contrato, troca e criatividade entre os K«sêdjê
Authors: Souza Marcela Stockler Coelho de
Published: May 2022

Este artigo trata da experiência do povo K«sêdjê (Suyá) com umcontrato de cessão de direitos sobre grafismos para um fabricante de sandálias,incluindo a utilização de um padrão de pintura corporal feminina parafins publicitários. Dois aspectos desta experiência vão reter a atenção: primeiro,a dificuldade posta pelo fato de que os padrões de pintura corporalfeminina então utilizados pelos K«sêdjê eram todos parte do repertório gráficoalto-xinguano, não lhes pertencendo, portanto, e sim a seus vizinhos.Segundo, as negociações que se seguiram ao que os K«sêdjê interpretaramcomo uma quebra de contrato quando, um ano depois, desenhos que reconheciamcomo seus foram reaproveitados em sandálias de outra linha domesmo fabricante. O primeiro momento servirá de ponto de partida parauma tentativa de delinear certos aspectos do modo de criatividade próprioaos K«sêdjê. A partir do segundo, serão abordadas as diferentes concepçõesda natureza dos produtos dessa criatividade sustentadas pelos diversos atores(e da forma das transações em que figuraram), confrontando o que chamareio modelo do contrato e o modelo da troca. À guisa de conclusão, proponhover esses dois modelos como correspondendo a distintos modos decriatividade, os quais implicam diferentes concepções de “propriedade”.
Histórias tariano e tukano: política e ritual no rio Uaupés
Authors: Andrello Geraldo
Published: May 2022

Este artigo trata de um processo recente envolvendo grupostukano e tariano do rio Uaupés, noroeste da Amazônia, em um debate emtorno do reconhecimento oficial pelo Estado brasileiro da Cachoeira deIauaretê como patrimônio cultural do país, no contexto da nova política deregistro de bens culturais de caráter imaterial. A reflexão não se refere à novapolítica em si, ou à forma como vem sendo conduzida e executada pelosórgãos responsáveis. O foco central são os efeitos no contexto das própriasrelações entre os grupos indígenas, dos embates que engendrou. Sugiro queo evento e seus efeitos evocam uma dinâmica político-ritual pré-existente,acionando um corpus de conhecimentos em grande medida compartilhadoe que é objeto de disputas simbólicas referentes à ocupação histórica deIauaretê, uma localidade multiétnica semiurbana no rio Uaupés.
Apresentação
Authors: Lima Antonio Carlos de Souza
Published: May 2022

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A produção política da repulsa e os manejos da diversidade na saúde indígena brasileira
Authors: Teixeira Carla Costa
Published: May 2022

Considerando a permanência de práticas e percepçõesconcernentes ao princípio do higienismo e da busca por mudançascomportamentais observadas nas ações cotidianas dos profissionais da saúdee da engenharia sanitária nas terras indígenas, este artigo busca refletirsobre os processos políticos, normativos e técnicos que sustentam sua atualizaçãono contexto atual de conquista de direitos pelos povos indígenas. Destaforma, aponta para os manejos da diversidade cultural na história recente denosso país que, em nome da inclusão dos povos indígenas, parecem estarproduzindo novas hierarquias cívicas e civilizatórias. Ao privilegiar a análisedo manual de formação do agente indígena de saneamento, inserindo-o nocontexto recente de construção da política de saúde indígena brasileira, estetrabalho busca contribuir para a compreensão de processos de estatizaçãoespecíficos que articulam práticas e normas, emoções e regras, representaçõese valores, profissionais de saúde (e engenharia), indígenas (“usuários” elideranças) e gestores no cerne da construção da cidadania diferenciada.
O exercício da tutela sobre os povos indígenas: considerações para o entendimento das políticas indigenistas no Brasil contemporâneo
Authors: Lima Antonio Carlos de Souza
Published: May 2022

O objetivo do presente texto é lançar alguns elementos para sepensar sobre as formas pelas quais se dá a transmissão de conhecimentospara o exercício de poderes de Estado para além daquelas modelizadas pelainstituição escolar, seja em organizações formais de ensino e aprendizagem,ou em processos de treinamento específicos característicos de organizaçõesburocráticas, e pautados uns e outros essencialmente na codificação escrita.Com intenção de suscitar evocações e o raciocínio por homologias, tomocomo ponto de partida o estudo, no plano de um modelo histórico formal,da tutela como exercício de poder, e o que chamei de tradições de conhecimentospara a gestão colonial da desigualdade, na formação de quadros deagências de governo para ação direta junto aos povos indígenas, usando comocampo empírico o treinamento de técnicos em indigenismo da FundaçãoNacional do Índio nos anos 1970-1980.
Sobre artefatos-pessoa e produção ritual no baixo Oiapoque (Amapá)
Authors: Andrade Ugo Maia
Published: May 2022

Bancos zoomorfos, Mastros, Clarinetes e Maracás são itens fundamentaisdo turé dos índios Galibi-Marworno do norte do Amapá. Aocontrário de meramente comporem o acervo de objetos rituais, esses elementossão, simultaneamente, partícipes e destinatários da cerimônia, umavez que são Karuãna com invólucro de artefatos atuantes, notadamente nacura e causação de doenças. O presente texto visa refletir sobre a gênese daagência extra-humana e sobre modos de distribuição da pessoa no pensamentoxamânico regional que atribui intencionalidade e capacidade de relaçãoaos artefatos rituais.
New record and update on the geographic distribution of the Egyptian Tomb Bat Taphozous perforatus (E. Geoffroy, 1818) in Cameroon
Authors: Eric Moïse Bakwo Fils  , Kingha Zebaze Jasmine Flora  , Ervis Manfothang Dongmo , Manga Mongombe Aaron  , Jan Decher
Published: May 2022

The Egyptian Tomb Bat Taphozous perforatus is an emballonurid whose presence in Cameroon is least known. While there are previous records in the country from Waza and Yabassi, they are contested. Available publications fail to mention the presence of this species in the country, thus more information is needed to evaluate its presence. Recently, five specimens were captured near a cave entrance in Bocklé, Garoua in the Sahelian zone of northern Cameroon, adding a new locality to the distribution of the species. The discovery of this roost unequivocally confirms the presence of this species in Cameroon and indicates that the species has a wide distribution in the country as a resident species. Detailed geographical distribution of this species in Africa, along with detailed descriptions and photographs of available specimens are provided.
New additions to the lichen biota of Assam from Dhubri district, northeastern India
Authors: Biswas Suparna , Daimari Rebecca , Islary Pungbili , Nayaka Sanjeeva , Joseph Siljo , Dalip Kumar Upreti  , Sarma Pranjit
Published: May 2022

The present study deals with the exploration of lichen diversity in Dhubri district of Assam state. A total of 42 lichen species belonging to 10 families and 16 genera were recorded, the majority of which were crustose (93%) with Graphidaceae as the dominant family. Eleven of the lichen species under eight genera are new additions to the lichen biota of Assam.