bluuebunny/crossref_metadata_2025 huggingface dataset:
RP-HPLC Method for Quantification of Bilastine and Monteleukast Sodium in Pharmaceutical Dosage form
Authors: Bhanu Mohammed Sameera , Dadi Vasudha , Rao Yarraguntla Srinivasa , Prasad Rao K Vara
Published: April 2023

A simple, accurate, precise and robust reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the simultaneous estimation of Bilastine and Monteleukast Sodium in bulk and pharmaceutical dosage form. Chromatographic separation was performed on an Zodiac sil RP C18 column (100mm × 4.6mm, 3µm) with mobile phase consist a mixture of 75:25% v/v acetonitrile: phosphate Buffer pH adjusted to 5.2 with ortho-phosphoric acid in an isocratic elution mode, at a flow rate of 1 ml/min. The detection was monitored at 272nm. The retention time of Monteleukast Sodium and Bilastine were found to be 3.668 min and 2.746 min respectively. Linearity range was found between 20-100µg/ml for Bilastine with correlation coefficient of 0.999 and 5-25µg/ml for Monteleukast Sodium with correlation coefficient of 0.999. This method was validated with respect to linearity, precision, accuracy, ruggedness, limit of detection, limit of quantification and robustness. This method was successfully applied for the simultaneous estimation of Bilastine and Monteleukast Sodium in bulk and pharmaceutical formulation.
Analysis of H-index and Papers Citation in Computer Science Field using K-Means Clustering Algorithm
Authors: Obaid Omar Ibrahim
Published: April 2023

This paper provides an analysis of H-index and paper citations in the computer science field using K-Means Clustering Algorithm. By leveraging cutting edge visual analytics through the use of Power BI and Orange Data Mining tool with K-Means clustering algorithm, we are able to present a comprehensive review of how H-index and citations impact the scholarly evaluation of authors in computer science field. The analysis obtained will assist academics seeking to expand their research influence while providing additional context to the general audience seeking to understand how machine learning algorithms can contribute to data exploration. The analysis conducted has revealed that area of research which has the highest value of citation and H-index include the following topics: Artificial-Intelligence, Computational-Intelligence, Data-mining, Evolutionary-Algorithms, and Big Data Analytics. Finally, the analysis of this research clearly demonstrated that paper citations remain an important factor for determining scientific impact in disciplines such as computer science given its close relationship with established metrics such as h-index scores.
İlkokul Düzeyinde Yaratıcı Drama Uygulamalarının Akademik Başarıya Etkisi: Bir Meta Analiz Çalışması
Authors: YILMAZ Muhammet , YÜKSEL Reyhan , KURT Murat , TOY Mehmet
Published: April 2023

Meta analiz farklı çalışmalarda ulaşılmış sonuçlar birleştirilerek genel bir sonuç çıkarmak için yapılan analiz anlamına gelmektedir. Bu çalışmada yaratıcı dramanın akademik başarıya etkisi ele alınmıştır. Çalışmanın amacı; ilkokul düzeyinde uygulanan yaratıcı drama etkinliklerinin akademik başarıya etkisini ortaya koymak olarak belirlenmiştir. Araştırma örneklemini 2005-2022 yılları arasında Türkiye’de yapılan ve dâhil edilme kriterleri doğrultusunda 26 lisansüstü tez (23 yüksek lisans ve 3 doktora tezi) oluşturmaktadır. Araştırmaya dahil edilen lisansüstü tez çalışmalarına Yüksek Öğretim Kurulu Başkanlığı (YÖK) Tez Merkezi veri tabanından ulaşılmıştır. Tarama yapılırken "ilkokul", "drama", "yaratıcı drama", "deneysel", "başarı" ve "ilkokul, başarı, drama" anahtar kelimeleri kullanılmıştır. Araştırmaya dahil edilecek çalışmaların gruplanması ve istenilen verilere kolayca ulaşılabilmesi için kodlama formu kullanılmıştır. Yayın yanlılığı, etki büyüklüğü ve heterojenlik testlerinin hesaplanmasında Comprehensive Meta-Analysis (CMA) yazılımından yararlanılmıştır. Begg and Mazumdar rank correlation istatistiği sonuçlarına göre 26 çalışma ile başlayan analizlerde; p değerinin (p=0.000) 0,05’ten küçük olması yayın yanlılığına işaret etmiştir. Bu durumda bireysel çalışmaların genel etkiyi etkileme düzeyleri tekrar incelenmiştir. Yayın yanlılığını azaltmak için bireysel etki büyüklüğü yayın yanlılığı oluşturan çalışmalar analiz dışı bırakılmıştır. Bu durumda analize 18 çalışma verisi ile devam edilmiştir. Araştırma sonuçlarına göre; analize dahil edilen çalışmaların çok büyük bir kısmı huni grafiğinin iç kısmında toplanmış ve ortak etkiye katkısının yüksek olduğu tespit edilmiştir. Araştırma sonuçları yaratıcı drama yönteminin akademik başarıyı artırmada etkili olduğunu göstermektedir. Bu nedenle akademik başarıyı artırmak amacıyla öğretim programlarında yaratıcı drama etkinliklerine daha fazla yer verilebilir.
Peer interactions, local markets, and wages: Evidence from Italy
Authors: Brunetti Irene , Intraligi Valerio , Ricci Andrea , Vittori Claudia
Published: April 2023

This paper investigates the relationship between the spatial distribution of occupations with a high content of peer interactions and wages among Italian provinces. At this aim, we use a unique employer-employee dataset obtained by merging administrative data on wages and labor market histories of individuals, with survey data on job tasks and contents. The spatial distribution of jobs intensive in peer-interactions is further measured according to the occupational structure of Italian provinces. The econometric analysis shows that the concentration of peer interactions leads to higher wages at the province level. These results are robust to firms and workers’ heterogeneity and endogeneity issues.
Oral Iron Treatment for Children with Nutritional Anaemia and Factors that Affect the Results
Authors: Yar Shahrukh , Afridi Jahanzeb Khan , Khan Asad , Rahman Tanzeel Ur , Rashid Nasar , Ahmad Tahir
Published: April 2023

Background: This study aimed to investigate the efficacy of oral iron therapy in childhood nutritional anaemia and to identify the factors affecting the outcome of 100 patients. Data was collected from the medical records of the patients. The study showed that oral iron therapy was effective in treating childhood nutritional anaemia, with the majority of patients (84%) achieving complete haematological recovery. The factors associated with successful treatment included age, gender, clinical presentation, and duration of iron therapy. The study shows suggest that oral iron therapy is an effective and safe treatment option for childhood nutritional anaemia and that age, gender, clinical presentation, and duration of iron therapy may affect the outcome of treatment. Methodology: This study was conducted department of pediatric hmc hospital Peshawar from jan 2021 to jan 2022 . The study included 100 patients aged between 2 and 12 years with childhood nutritional anaemia. Data was collected from the medical records of the patients, including demographic characteristics, clinical presentation, laboratory results, duration of iron therapy, and outcome of treatment. Descriptive statistics were used to analyze the data and logistic regression analysis was used to identify the factors affecting the outcome of treatment. Results: According to the findings, 84% of the kids who received oral iron therapy for treating childhood nutritional anaemia experienced positive effects. Age (OR=2.5, 95% CI: 1.3-4.7), male gender (OR=2.1, 95% CI: 1.1-4.3), clinical presentation (OR=2.8, 95% CI: 1.3-5.8), and length of iron therapy (OR=1.2, 95% CI: 1.1-1.3) were all linked with successful treatment. Conclusion: The study shows suggest that oral iron therapy is an effective and safe treatment option for childhood nutritional anaemia and that age, gender, clinical presentation, and duration of iron therapy may affect the outcome of treatment. Further studies are needed to confirm these findings and to identify the optimal duration of iron therapy in the treatment of childhood nutritional anaemia. keywords: Childhood nutritional anaemia, Oral iron therapy, Outcome, Factors,
Association Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD): A Cross-Sectional Study
Authors: Khan Jibran Umar Ayub , Fayaz Humera , Wahab Abdul , Haq Zia Ul , Iffat Syeda , Alam Intikhab
Published: April 2023

Background: In patients with gastrointestinal symptoms Helicobacter pylori has been known to cause non alcoholic fatty liver disease However, there is still gap in literature regarding it in our local clinical setting population. Objective: The study aims to determine association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease Materials & Methods: The cross-sectional study was done on 100 patients at the MMC General Hospital, from January 2022 to June 2022. Participants with both abdominal ultrasound (US) for diagnosing fatty liver disease and stool antigen for the detection of H. pylori infection were included. The pros and corns as well as rationale of the study were clearly explained to the participants with an option to withdraw from the study if needed .The data analysis was done by SPSS version 25. Results: Among cases 15(30%) patients were male and 35(70%) were female while among controls 16(32%) were male and 34(68%) were female. Among cases 35(70%) patients and among controls only 18(36%) participants were positive for H-Pylori. Frequency of H-Pylori infection was significantly higher among cases as that of controls. i.e. 70% vs. 36%, p-value<0.001 Odds ratio of 4.14 shows that among cases risk of H-pylori infection was 4.14 times higher as compared to controls. Data entry and analysis was done with SPSS version-25. Quantitative variables were presented with mean±SD and qualitative variables with frequency and percentage.Frequency of H-Pylori was compared among cases and controls with Chi Square test. Conclusion: There is an association between NAFLD and Hpylori indicating the need for regularly screening such patients. Keywords: NAFLD, H Pylori
Individual and Combined Efficacy of Antibiotics and Probiotics on the Growth of Broiler Chicken
Authors: Khan Sangeen , Sattar Abdul , Lodhi Sumaira Salahuddin , Abbas Azhar , Ali Farman , Rahman Shafiq Ur , Ahmad Abbas , Abbas Muhammad , Ahmad Naqeeb , Ullah Kaleem , Shoukat Muhammad Usman , Ullah Zia , Tauseef Isfahan , Naveed Muhammad
Published: April 2023

In Pakistan the poultry industry continues to grow to meet the demand for poultry products in world markets therefore, there is need for using probiotics instead of antibiotics to have maximum benefits. The present research work was carried out to study the effect of antibiotic and probiotic in combination and alone on the growth performance of broiler chickens. The effect of antibiotic and probiotic on the body weight gain, feed intake and feed conversion ratio was noted in all the birds. The study was conducted on 300 broilers chickens were divided into 10 groups. Nine of them having 25 birds with the control group having 75 birds. The antibiotic group was named A (A1, A2 and A3). In which A1 was received 150 mg Neomycin/kg feed, A2 was 200mg Neomycin/kg feed and A3 was 250 mg Neomycin/kg respectively. The probiotic group was named “B” and it was further sub divided into B1, B2 and B3. In which B1 was offered 1.5g Protexin/kg feed, B2 was offered 2g Protexin/ kg feed and B3 was 2.5g Protexin/kg feed. The group that received both antibiotic and probiotic was named C and was further divided into C1, C2 and C3. In which C1 was offered 150mg Neomycin and 1.5g Protexin/kg feed, C2 was offered 200 mg Neomycin and 2g Protexin/ kg feed and C3 was offered 250 mg Neomycin and 2.5 g Protexin/kg feed. We concluded that Neomycin antibiotic has not such better effect on the body weight gain, feed intake and feed conversion ratio. Protexin probiotic given alone improves the body weight gain, feed intake and feed conversion ratio. And the best result obtain was that of antibiotic and probiotic given in combination which significantly improves the body weight gain, feed intake and feed conversion ratio.
Variations in Serum Iron Profile, in Pre and Post Hemodialysis Patients of Chronic Renal Failure
Authors: Memon Majida , Memon Jawaid Hussain , Memon Faima Rani , Memon Aqeela , Ghafoor Abdul , Mumtaz Salma
Published: April 2023

Objective: To determine the variations in iron profile in pre- and post-hemodialysis patients with chronic renal failure. Material and methods: This cross-sectional study was conducted at the physiology department with the collaboration of the urology department of Liaquat University Hospital Hyderabad, from April 2021 to September 2021. Patient of either gender with chronic kidney disease between the ages of 18- and 50-years undergoing hemodialysis were included. Blood samples were collected using serum tubes to analyze the iron profile before and after dialysis. Changes in hematological parameters were evaluated by comparing pre and post data. All data were recorded in a proforma and entered into the SPSS 26.0 version for the purpose of analysis. Results: A total of 167 patients were studied; their mean age was 43.23+12.90 years. Out of all study subjects 61.1% were males and 38.9% were females. The mean duration of dialysis was 13.40 ± 2.88 months. As per the pre- and post-serum iron profiles, the average serum iron level, serum ferritin level, and serum TIBC were statistically insignificant (p- >0.05). Conclusion: In conclusion, the iron levels before dialysis were observed to be higher than after dialysis, and the average levels of serum ferritin and total iron binding capacity (TIBC) were found to be higher after dialysis, albeit statistically insignificant. Keywords: Hemodialysis, serum iron, ferritin, TIBC
Knowledge and Awareness of Community People on Dengue Fever Infection: A Cross-Sectional Study
Authors: Akhter Erum , Jawed Bilal , Ishaqui Azfar Athar , Ahmed Zeeshan , Ahmed Salman , Mustafa Bilal , Ali Imran , Ahmed Moeen , Imran Muhammad , Baig Sadia Ghousia , Siddiq Afshan , Ahmed Shayan
Published: April 2023

Objective: Pakistan has been suffering from epidemics of dengue infection in last two decades. One of the reasons of yearly high number of cases is due to lack of awareness and knowledge about prevention of dengue infection. The current study aimed to assess the level of knowledge and awareness of dengue infection common population of Karachi. Material and Methods: A cross-sectional survey-based study was carried out over a period of three months. First section comprised of demographic characteristics of participants, section two comprised of 7- items about the knowledge of dengue infection, while section three comprised of 5- items related to awareness and perception of dengue infection among participants. Results: A total of 201 participants were enrolled in the study with mean age of 26.9 years. Female participants were more as compared to male participants. Most of the participants belonged to low- or middle-income socio-economic status and had no history of dengue infection in the past. Less than half (39.8%) participants responded correctly that dengue mosquito breed in stagnant clean water. Around three-fourth population think that the chances of bite of mosquito is more in night time or dusk as compared to correct option of dawn. Around 37.3% participants were unaware that there is no vaccine available for the prevention or treatment of dengue infection. Around 30% respondents responded that antibiotics can be used for the treatment of dengue infection. Conclusion: The level of knowledge in the current study was observed to low as compared to the previous studies. The level of awareness and knowledge among common population needs to be improved among common population Keywords: Dengue, Knowledge, Awareness, Mosquito, Perception
Optimization, Fabrication and Characterization of Novel Meloxicam-Loaded Surface Attached Solid Dispersions to Ameliorate its Aqueous Solubility and Dissolution Employing Spray-Drying Technique
Authors: Shafique Shumaila , Mughal Ubed-Ur-Rehman , Dayo Abdullah , Mustapha Omer , Saleem Hina , Naeem Sabahat , Ahmed Salman
Published: April 2023

Objective: To formulate unmodified crystalline meloxicam solid dispersions by the use of surfactants and polymer. This polymeric particulate system is named as meloxicam-loaded surface attached solid dispersion (MSDs). Methodology: This experimental study was conducted at Lab of Physical and Industrial Pharmacy, Hanyang University, South Korea. The duration of this study was around seven months. The first phase of this study (optimization and fabrication) was completed within 3 months, while, solubility, dissolution and physicochemical characterization was completed in next 4 months. These surfaces attached solid dispersions were prepared by using spray drying technology. Moreover, HPMC and SLS were used as hydrophilic carriers. Various MSDs were prepared using carriers/drug, and were evaluated for aqueous solubility and dissolution studies. Results: Amongst different formulation prepared, MSDs3 having Meloxicam/HPMC/SLS in a (1:0.5:0.5) gave the highest solubility and dissolution (i.e. from 0.25 ±0.17ug/ml of meloxicam to 153 ±5.3ug/ml). Moreover, dissolution was enhanced from 2.96 ±0.55% to 47 ±1.07% at 15 minutes. Furthermore, physicochemical characterization was performed by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Conclusion: In conclusion we can predict a better solubility and dissolution of meloxicam in surface attached solid dispersion. Keywords: Meloxicam, solubility enhancement, spray drying, surface attached, solid dispersion
Facial Nerve Morbidity after Superficial Parotidectomy in the Absence of Nerve Conductor: A Cross-Sectional Study from a Tertiary Centre in Pakistan
Authors: Hashmi Fazila , Abbasi Mushtaq Ahmed , Akbar Muhammad , Chaudhry Salman Majeed , Arain Sohail Yousif , Ghufran Samar , Dhahri Mehvish Adeel , Dhahri Adeel Abbas
Published: April 2023

Objective: After superficial parotidectomy, the incidence of facial nerve injury for pleomorphic adenoma of the parotid gland remains the topic of interest despite different techniques to identify the nerve during surgery. We aim to evaluate the incidence of facial nerve injury in patients undergoing superficial parotidectomy without a nerve conductor. Material and Methods: After calculating the sample size, 101 patients, irrespective of age and gender, were included in this cross-sectional study at the Department of Surgery, for nine years, from 1st January 2012. The primary outcome was the incidence of temporary or permanent facial nerve injury with a follow-up period of 12 months. The data was calculated using SPSS version 23, where mean and standard deviation were calculated for continuous variables, and frequencies were calculated for categorical data. Results: Facial nerve injury was evident in 16/101 (15.8%) patients. Among these, the main truck of facial nerve was involved in 6(5.9%), temporary loss of function in 4(4.0%) and permanent injury in 2(2.0%). The most common branch of facial nerve affected was the marginal mandibular nerve (6, 5.9%), of which 4(4.0%) had a permanent loss. Additionally, four (4.0%) patients developed salivary fistula, whereas 2% developed Frey’s syndrome. Conclusion: Facial nerve injury should be clearly explained, in the consent, to the patient for a medicolegal purpose. Where the nerve stimulator is not available, identification of the proposed anatomical landmarks allows a safe recognition of the facial nerve Keywords: Pleomorphic adenoma, facial nerve, facial nerve injury, superficial parotidectomy
Frequency of Factors Leading to Oligohydramnios in Patients Presenting to Women and Children Hospital, Dera Ismail Khan
Authors: Shah Faryal , Ghafoor Maria , Bibi Najma , Saleem Aimen , Babar Rubina , Azam Abeela
Published: April 2023

Objective: To determine the frequency of factors leading to oligohydramnios in patients presenting to women and children hospital, Dera Ismail Khan. Materials and methods: This cross sectional study was conducted in obstetrics and gynecology department, Women and children teaching hospital Dera Ismail khan from 1 August, 2020 to 31 January, 2021, comprising 185 patients. Sampling technique used was convenient non-probability sampling. Factors leading to oligohydramnios (Primigravida, history of abortion, gestational age > 40 weeks, history of UTI and history of high blood pressure) were noted as per operational definition and recorded on especially designed proforma. Result: A total of 185 pregnant women with oligohydramnios were included in the study. Factors leading to oligohydramnios (Primigravida, history of abortion, gestational age > 40 weeks, history of UTI and history of high blood pressure) were noted. Age range in this study was from 18 to 35 years with mean age of 27.178±2.39 years and mean weight was 68.908±3.82 Kg. Factors leading to oligohydramnios were, primigravida 34.1%, History of Abortion 27%, gestational age > 40 weeks 45.4%, history of UTI 15.7% and history of high blood pressure was 21.1%. Practical implication: This study will help the gynecologists in diagnosis and analysis of the oligohydramnios based on the risk factors discussed in this research. Conclusion: It can be concluded from our study that most common associated factors were primigravida, history of abortion, gestational age > 40 weeks, history of UTI and history of high blood pressure. Keywords: Amniotic fluid, Gestation, Hypertension, Pregnancy, Oligohydramnios, Primigravida.
Modified Ultrafiltration and Acute Kidney Injury in Patients Undergoing Open Heart Surgery Using Cardiopulmonary Bypass
Authors: Azam Hammad , Alshammary Ayed Amesh , Farooq Sajid , Ghaffar Sahrish , Shahzadi Adeela , Baig Mirza Ahmad Raza
Published: April 2023

Objective: To determine the incidence of acute kidney injury (AKI) in patients undergoing open heart surgery using cardiopulmonary bypass (CBP) with and without modified ultrafiltration (MUF). Materials and Methods: A total of 150 patients who underwent open heart surgery using CPB in our hospital from Jan-2022 to Dec-2022. In group A patients MUF was performed during the CPB and atleast 1000 ml of volume was removed using MUF. While in group B patients, no filtration was performed during CPB. In ICU all patients were followed till three days after surgery to determine the incidence of AKI. Results: Mean age was 53.4±10.9 years in MUF group versus 55.6±11.8 years in control group, p-value 0.23. Majority, 53 (70.7%) patients were male in MUF and 57 (76%) in control group, p-value 0.55. Mean CPB time was 101.6±45.2 mins in MUF and 96.5±39.1 mins in control group, p-value 0.46. Mean X-clamp time was 47.5±19.3 mins in MUF and 51.4±21.6 mins in control group, p-value 0.43. The incidence of AKI was comparable, with frequency rate of 3 (4.0%) in MUF group versus 1 (1.3%) in control group, p-value 0.31. Conclusion: In present study, the incidence of AKI in MUF and control group was almost similar. So according to the results of present study, the use of MUF has no role in preventing or aggravating AKI in patients undergoing CPB. Keywords: Acute kidney injury, cardiopulmonary bypass, modified ultrafiltration.
Are Clinicians Communicating Adequately with Radiologists Through Radiological Requisition? A Clinical Audit Assessing Current Local Practice
Authors: Orakzai Zubair Janan , Begum Tabassum , Rashid Shamoona , Akhtar Nasreen
Published: April 2023

Background: To prevent controversy, the request forms were selected to use a method of convenience sampling and also included forms from both inpatient and outpatient different department. The aim of this study whether the different request forms that were submitted to the radiological department and notice that the patients having complete information in each form of different department of radiology. Study design: This was retrospective and descriptive study. The study was carried out at the department of Radiology, MTI Mardan Medical Complex, Mardan for six months duration from May 2022 to October 2022. Methods: The total participants request form were 300 which distribute, 85 forms in CT (computated tomography), 105 forms in MRI (magnetic resonance imaging) and 110 forms in US (ultrasound image). The completeness of the data entered by the doctors was examined on the forms to avoid bias. Results: Our audit information indicate that to analysed 300 request forms were filled out just the name of patients as well as part of examination. The different category of request form included name, age, diagnosis diseases, relevant history and Dr. Name or contact number. Conclusion: The referring doctors managed to fail to fully and precisely fill out all of the disciplines. To recognize this system and communicate about how it may be done better, we suggest having discussions with radiologists and doctors from different departments. Keywords: Radiologists, Radiology request form, Adequate.
Role of Kangaroo Mother Care in Growth and Breast Feeding Rates in Very Low Birth Weight (VLBW) Neonates
Authors: Nazir Saeed , Mubashar Aqsa , Naeem Bilquis , Riaz Maira , Aman Lubna , Salman Nayla
Published: April 2023

Introduction: World Health Organization has recommended kangaroo mother care for every infant weighing less than 2,000gs who is stable. The Kangaroo mother care (KMC) has been established for last few decades because there are insufficient resources in developing countries to care for infants with low birth weights (LBW). Methodology: It is a non-controlled retrospective observational cohort. Results: If we compare the means of the weights and lengths at birth, one month and three months there is statistically significant improvement in both groups. The growth at three months is better in KMC group. The mean of the day of breastfeeding and the KCM intervention are positively associated. The initiation of breastfeeding is different in both groups. Practical Implications: The intervention has long term benefits as the results have shown better association of KMC at three months. Early initiation and high rate of breastfeeding in KMC group also suggests positive association. Conclusion: Kangaroo mother care can be implemented as it shows positive outcomes. Keywords: Kangaroo Mother Care, Kangaroo mother method, Exclusive breastfeeding, neonatal care, Low birth weight.
BCL-2 Protein Ailesi ve Kanser
Authors: BABACAN Derya
Published: April 2023

Bu derlemenin odak noktası, BCL-2 ailesi proteinlerinin apoptozu düzenlemedeki rolüdür. Apoptoz, gelişimsel süreçte ve stres yanıtı olarak ortaya çıkan çok önemli bir biyolojik süreçtir. Bozulmuş apoptotik mekanizma kanser gelişiminde merkezi bir rol oynar ve ayrıca bilinen sitotoksik tedavilerin etkinliğini azaltır. B-hücreli lenfoma 2 (BCL-2) protein ailesinin üyeleri, pro- veya anti-apoptotik aktivitelere sahiptir ve son on yılda apoptozu, tümör oluşumunu ve antikanser tedavisine hücresel yanıtların düzenlemedeki önemleri açısından yoğun bir şekilde incelenmiştir. Apoptoz kaynaklı hücre ölümünün indüklediği inflamatuar yanıtlardan dolayı günümüzde apoptozu hedef alan antikanser ilaçların geliştirilmesi giderek daha fazla dikkat çekici hale gelmiştir. BCL-2 ailesi proteinlerinin apoptoz regülasyon mekanizması araştırılmış ve bütün bulgular, BCL-2 ailesi proteinlerinin kanser tedavisindeki potansiyelinin ne kadar önemli olduğunu vurgulamaktadır.
Focal laser and intravitreal bevacizumab for choroidal neovascularization secondary to Grönblad–Strandberg syndrome
Authors: Oderinlo Olufemi , Akanbi Toyin
Published: April 2023

Introduction: Pseudoxanthoma elasticum is a rare genetic disorder. It has several ocular features including angioid streaks and choroidal neovascularization which can significantly affect vision.

Case Report: A 50-year-old man presented with nine months history of poor vision affecting both distant and near vision. His best corrected visual acuities were 6/18 right eye and 1/60 left eye. His anterior segments were normal. Funduscopy revealed linear hyperpigmented irregular branching peripapillary lesions; angioid streaks both eyes. He had bilateral speckled retina pigment epithelial hyperpigmented lesions interspaced with dot hemorrhages in the macula region suggestive of likely choroidal neovascularization. He had “peau d’orange” skin appearance around his neck. Fundus fluorescein angiography showed features of occult subfoveal choroidal neovascularization. He was referred to a physician and had a skin biopsy which revealed histologic features of Pseudoxanthoma elasticum. He was treated with bilateral focal argon laser. However he had right intravitreal Bevacizumab after a large ipsilateral subfoveal hemorrhage. His visual acuities remained stable afterward.

Conclusion: Patients with Pseudoxanthoma elasticum have to be closely monitored for ocular manifestations. Choroidal neovascularization should be detected early and promptly treated. Antivascular endothelial growth factor injections have become the preferred treatment option for choroidal neovascularization in these patients.
Resenha de: Aspectos do Novo Radicalismo de Direita (T. W. Adorno)
Authors: Grison Everton Marcos , Maeso Benito Eduardo
Published: April 2023

Resenha de: Aspectos do Novo Radicalismo de Direita (T. W. Adorno)ADORNO, Theodor W. Aspectos do Novo Radicalismo de Direita. Tradução e apresentação de Felipe Catalani. São Paulo: Unesp, 2020. (Coleção Adorno)
A possível interlocução entre Foucault e o sistema prisional no Brasil
Authors: Costa Abraão Lincoln , Rockenbach Sérgio Eduardo
Published: April 2023

Com as frequentes tragédias ocorridas no âmbito das instituições prisionais no Brasil, surge a necessidade de debater a crise penitenciária e identificar as suas possíveis causas. O artigo propõe uma análise da falência da pena de prisão sob a abordagem das teorias do filósofo Michel Foucault, contidas principalmente em sua obra Vigiar e Punir: história da violência nas prisões. Utilizando-se de método similar ao do próprio autor, serão realizadas comparações de medidas punitivas anteriores à reforma penal com a conjuntura do atual ordenamento jurídico brasileiro. Com base no conteúdo histórico-filosófico da referida obra, será exposto o conceito de gestão dos ilegalismos, o qual se mostrará pertinente para explicar um dos fatores que contribui para a tão debatida crise no sistema penal. Em síntese, esperamos aproximar as teorias foucaultianas da ineficiência do sistema penal brasileiro.
Pela paz, pela utopia: anarquismos no pós-Segunda Guerra Mundial em abordagem transnacional
Authors: Viana Allyson Bruno
Published: April 2023

Resenha do livro Faces da Hidra Anarquista: linguagens utópicas e projetos políticos (1945-1970), de Cláudia Tolentino Felipe, publicada pela editora Cancioneiro, em 2021
Nota sobre a guerra, o jogo e o inimigo
Authors: Honesko Vinícius
Published: April 2023

A nota procura apresentar abordar os conceitos de guerra, jogo e inimigo a partir da leitura e questionamento das construções teóricas apresentadas por Carl Schmitt a respeito do tema. De início, aborda a questão da circularidade que se dá na constituição dos conceitos de "guerra" e "inimigo" em Schmitt, apontando como o autor estava ciente dessa questão. Na sequêcia, procura evidenciar como o conceito de jogo fora propositalmente obliterado por Schmitt na construção de sua teorização da guerra, sobretudo em virtude das implicações teóricas que isso poderia causar à sua concepção do político. Assim, procura apresentar a questão do "agonal" no âmbito da guerra, demonstrando como na Antiguidade Clássica - e isso a partir de autores como Huizinga, Vernant e Strauss - a guerra ritual (agonal) cumpria um papel fundamental na constituição do político. Por fim, tais implicações são apresentadas como contraparte à concepção schmittiana da guerra, de modo que as perspectivas de pesquisas sobre a problemática bélica possam ser redimensionadas para além da captura estatal dos mecanismos de guerra e de consequente obliteração do agônico que nesta se dá.
Os Tempos na (depois da) História: Revoltas, Crise e Guerra
Authors: Ruminott Sergio Villalobos , Cavalletti Andrea , Honesko Vinícius Nicastro
Published: April 2023

Apresentação do dossiê Os Tempos na (depois da) História: Revoltas, Crise e Guerra
A prática da avaliação psicológica das queixas escolares fundamentada na Psicologia Histórico-Cultural
Authors: Vieira Ana Paula Alves , Facci Marilda Gonçalves Dias
Published: April 2023

Os resultados de testes psicológicos são comumente usados para diagnosticar crianças que enfrentam dificuldades no processo de escolarização com algum transtorno/distúrbio, sem levar em conta as condições histórico-sociais, apresentando pouca possibilidade de superação da dificuldade no âmbito educativo. Por isso, pesquisadores têm proposto a realização de avaliações a partir da Psicologia Histórico-Cultural (PHC), teoria que se distingue teórica e metodologicamente das que embasam as avaliações tradicionais. Em busca de contribuir com esses estudos, o objetivo deste artigo é apresentar resultados de uma pesquisa acerca de procedimentos para a realização do processo de avaliação psicológica das queixas escolares. Foram planejadas e realizadas avaliações de oito crianças com tais queixas. Como resultado, apresenta-se uma síntese dos procedimentos realizados: encontro inicial com os familiares/responsáveis, os professores e as crianças, atividades com elas e encontro final para apresentar os resultados obtidos e possibilidades de intervenção. O procedimento considerou a formação social dos processos psicológicos a partir da análise da atividade-guia. Considera-se que este trabalho contribui para a prática do psicólogo que busca realizar avaliações psicológicas que se distinguem das tradicionais e para o desenvolvimento de posteriores pesquisas que englobem outros períodos do desenvolvimento e que tenham como finalidade mudanças no âmbito escolar, familiar e societário.
Saúde mental de agentes penitenciários, relacionada ao ambiente de trabalho
Authors: Simoni Jéssica Dinara Sabará , Kobori Eduardo Toshio
Published: April 2023

Este artigo pretende analisar a atuação dos agentes de segurança penitenciária, principalmente no que se refere à saúde mental dentro do ambiente de trabalho. Para isso, utilizamos o referencial foucaultiano com o intuito de contextualizar o ambiente do sistema carcerário, utilizamos também a psicodinâmica do trabalho para apresentar questões acerca do sofrimento e do estresse nesse ambiente. Nesse sentido, buscamos colocar em evidência a invisibilidade que ocorre pela forma gerencial das prisões, fechadas e hierarquizadas, bem como pelo sofrimento advindo do preconceito e exclusão dentro da sociedade. Sendo assim, a relevância deste trabalho se dá devido ao fato de existirem poucos estudos sobre a temática e, diante disso, surge a preocupação em trazer mais visibilidade a ela, evidenciando as mazelas dessa classe profissional e proporcionar a reflexão sobre o assunto. Ademais, as condições laborais dos agentes de segurança penitenciária demandam a criação de projetos e estratégias mais eficazes para lidar com o seu cotidiano, bem como promover a diminuição do estresse e mais qualidade de vida para os trabalhadores.
Effects of Budesonide Plus Vitamin AD on Children with Bronchial Asthma and the Effect on Serum IgE and C-reactive Protein
Authors:   Neonatology Department, Shijiazhuang Fourth Hospital, Wang Yan , Tan Yongpan ,   Ultrasound Department, Shijiazhuang Fourth Hospital, Zhang Lian ,   Neonatology Department, Dingzhou People’s Hospital, Zheng Lina ,   Neonatology Department, Shijiazhuang Fourth Hospital, Han Liping ,   Neonatology Department, Shijiazhuang Fourth Hospital, Xie Juan ,   Neonatology Department, Shijiazhuang Fourth Hospital, Cui Yao ,   Neonatology Department, Shijiazhuang Fourth Hospital, Zhang Ming ,   Neonatology Department, Shijiazhuang Fourth Hospital, An Xiaoyan ,   Neonatology Department, Shijiazhuang Fourth Hospital
Published: April 2023

Objective: To investigate the efficacy of budesonide plus vitamin AD in children with bronchial asthma and the efect on serum IgE and C-reactive protein (CRP). Methods: In this retrospective analysis, 80 children with bronchial asthma treated in our hospital from October 2018 to October 2020 were recruited and assigned 1:1 to receive either vitamin AD (control group) or budesonide plus vitaminAD (study group), with 40 cases in each group. Results: Budesonide potentiated the treatment efcacy of vitamin AD by 17.5% (P<0.05). Patients receiving the combined therapy exhibited more reduction in the serum concentrations of IgE and CRP versus those with monotherapy of vitamin AD (P<0.05). Patients in the study group had lower bronchial asthma symptom scores than those in the control group, suggesting more symptom mitigation produced by budesonide plus vitamin AD (P<0.05). Budesonide plus vitamin AD ofered better lung function restoration for patients versus vitamin AD alone, as evinced by the superior lung function indices (P<0.05). Patients with budesonide plus vitaminAD experienced a shorter duration of symptoms versus controls (P<0.05). Conclusion: Budesonide plus vitaminAD exerts a promising clinical efcacy in treating children with bronchial asthma.
Application of High Precision Mining for Optimising Load and Haul Operations at Kansanshi Mine, Zambia
Authors:   University of Zambia, Kangwa Katongo , Mutambo Victor ,   University of Zambia
Published: April 2023

Mining of copper and gold at Kansanshi is done in the Main and North West pits using hydraulic excavators and a mining fleet of haul trucks. In the recent past, there has been reduced truck deployment, increased truck and shovel waiting time, reduced production and reduced grade/quality of ore delivered to crushers. Therefore, there is need to improve productivity and optimise operations in mining, loading and hauling. This paper focuses on the use of High Precision Mining (HPM) through use of Wenco’s dispatching algorithm to achieve the best utilisation of all mining equipment and maximise production. The study involved establishing the precise bucket positioning, production rates, cycle times and monitoring the material type and quality /grade of ore delivered to the crushers. This was done by using BenchManager which relies on the motion of the Global positioning System (GPS) antenna scribing an arc as the excavator is rotated to determine the equipment’s centre of rotation by placing the bucket with the teeth flat on the ground (anywhere) and taking the rover and measuring left and right tooth on the outside of the teeth and taking note of the coordinates, first eastings then northings and lastly the elevation. With the tolerance of X=0.5m, Y=0.5m and Z=0.5m, it was noted that the events of a bucket mining out of the assigned polygon were reduced to about 50cm in distance from 34% to 15% and from 10% to 8% in terms of mismatches. The use of precision mining has led to reduced mining cost of about 10.3$/BCM, improved fleet/production reporting, high grade of the material delivered to the crushers of about 75% from the previous 65%. These results indicate that there is a strong business case for implementation of a Wenco fleet monitoring and dispatch system at the mine
Rapid Smartphone-based Image Reading for Assessing Quality of Active Pharmaceutical Ingredients of Commonly Prescribed Drugs-Lusaka Zambia
Authors:   University of Zambia, Nyirenda James
Published: April 2023

Third world countries suffer from supply of substandard therapeutic drugs and due to lack of robust quality testing facilities, many of these drugs find themselves in the dispensaries and various outlets for over the counter purchase. In order to ensure quality, simple yet informative tests are available and one of them is high performance thin layer chromatography. High Performance Thin Layer Chromatography (HPTLC) coupled with image acquisition by TLC software application on a smart phone and analysis by freeware Digitally enhanced Thin Layer Chromatography (DeTLC) respectively was performed using the minilab protocols for assessing quality of drugs dispensed at the University of Zambia clinic as well as drugs randomly bought from different pharmacies around Lusaka, Zambia. The quality of drugs was assessed by comparing retardation factors with standards and approximate percent active ingredient amounts were compared using the maximal K intensities derived by the DeTLC software for image analysis. Normalizing the spots to the 100% spot, mean values with respective standard deviations were : atenelol (85.6±0.5), ciprofloxacin (95.6±1.1), ketoconazole (78.2±1.1), mebendazole (95.5±1.1), nevirapine (96.7±1.1), penicillin v (100.5±1.1), quinine (92.9±1.1), rifampicin (99.3±0.7) and isoniazid (72.0±4.1). All the drugs tested were within the acceptable range of concentrations of the active pharmaceutical ingredient ( 0 to 5.3% Rf error). Thus, the simple robust HPTLC method coupled with simple to use digital imaging software provides a quick means to check on quality of the drugs dispensed.
Weather Forecasting over Iraq Using Machine Learning
Authors:   College of Science, University of Diyala, Baqubah, Iraq, .. Israa Jasim ,   Computer Science Department, University of Diyala, Diyala 32001, Iraq,   College of Science, University of Diyala, Baqubah, Iraq, Al-Nuaimi Bashar Talib Al , Baker Ther Intisar
Published: April 2023

The weather generally comprises various factors, such as wind speed, precipitation, and rainfall. Environmental weather forecasting is a demanding task for researchers, and in recent years it has attracted much study attention. Our assessment considers a wide range of weather conditions across Iraq utilizing information gathered from NASA's estimate of the world's energy resources for the years 1981 to 2021. Therefore, the correct forecast of meteorological parameters is a difficult challenge due to their changing environmental conditions. Random forest, decision tree, and GBR algorithms are used for weather forecasting. A comparison among used methods is performed and the RF is achieved the best results with accuracy, MAE, MSE, R2 of 92%, 0.5, 2.45, and 0.92, respectively.
New Public Service Sebagai Paradigma Administrasi Publik Pengawasan Obat dan Makanan
Authors: Dharma Alexander Arie Sanata
Published: April 2023

Tata kelola pemerintahan Indonesia mengalami big-bang decentralization pada masa reformasi dengan luaran utamanya adalah Otonomi Daerah. Salah satu tindak lanjut dari UU tersebut ialah terbentuknya sejumlah Lembaga Pemerintah Non Departemen pada tahun 2001, salah satunya adalah Badan Pengawas Obat dan Makanan. BPOM hadir sebagai instansi pusat yang memiliki perangkat di 33 ibukota provinsi dan 40 kabupaten/kota. Road Map Reformasi Birokrasi 2020-2024 menyebut bahwa Indonesia menyelenggarakan tiga paradigma administrasi publik secara paralel, mulai dari Weberian sampai dengan New Public Service. NPS hadir sebagai kritik pada Old Public Administration dan New Public Management dengan fokus utamanya adalah masyarakat. Penelitian ini menggunakan pendekatan kualitatif untuk menempatkan NPS pada konteks pengawasan Obat dan Makanan di Indonesia yang fungsinya dijalankan oleh BPOM. NPS terdiri dari 7 prinsip utama dan masing-masing memiliki kesesuaian dengan pelaksanaan pengawasan Obat dan Makanan di Indonesia. Peredaran komoditi seperti Obat tidak dapat dipandang sebatas NPM mengingat selain BPOM sebagai pemberi layanan dan industri farmasi sebagai penerima layanan, terdapat pula masyarakat yang akan memperoleh dampak langsung pada Obat dan Makanan yang beredar di Indonesia. Berdasarkan kesesuaian tersebut, direkomendasikan kepada BPOM untuk menekankan pentingnya paradigma NPS sebagai perspektif administrasi publik yang dianut oleh organisasi dan memuatnya pada dokumen-dokumen organisasi sehingga stakeholder memiliki pemahaman yang sama akan pola kerja BPOM berikut paradigma administrasi publik yang menyertainya.
Chronic Pulmonary Obstructive Disease (COPD) On High Resolution Computed Tomography
Authors: Ashraf Shahraz , Junaid Dar Ali , Nasir Urwa
Published: April 2023

The prevalent, preventable, and treatable chronic lung illness known as chronic obstructive pulmonary disease (COPD), which may be accurately detected on HRCT, affects both men and women worldwide. Objective: To evaluate the diagnostic features of chronic pulmonary obstructive disease (COPD) using high resolution computed tomography. Methods: This study included 120 patients with COPD at least having a comprehensive clinical record of 6MWT defined as COPD by a post-bronchodilator FEV1/FVC 70% with sustained expiratory flow limitation. The sample size was computed at 120 patients using convenient approach and non-contrast HRCT was performed using 64 slides scanning from the apex of the lung to the diaphragm. Emphysema scoring and -950 HU criteria were used to automatically partition the lungs without including the central airways. The data were entered and analyzed on SPSS version 22. Results: HRCT scan findings show that patients with parenchymal bands were 9(7.5%) with bronchial wall thickening, nodules were (24)20%, bronchiectasis were (23)19%, apical fibrosis were (19)15%, and tree on bud pattern were (12)10%. Conclusions: It is concluded that COPD is common in males and worsens in cigarette or tobacco smokers, with a prevalence of parenchymal bands, bronchial wall thickening, nodules, bronchiectasis, apical fibrosis, and tree-on-bud patterns.
Computational Prediction of Nigella sativa Compounds as Potential Drug Agents for Targeting Spike Protein of SARS-CoV-2
Authors: Ali Laraib , Saif Rashid , Hassan Raza Muhammad , Osama Zafar Muhammad , Zia Saeeda , Shafiq Mehwish , Ahmad Tuba , Anjum Iram
Published: April 2023

SARS-CoV-2 was first identified in Wuhan, China in December 2019 and has rapidly devastated worldwide. The lack of approved therapeutic drugs has intensified the global situation, so researchers are seeking potential treatments using regular drug agents and traditional herbs as well. Objectives: To identify new therapeutic agents from Nigella sativa against spike protein (PDB ID: 7BZ5) of SARS-CoV-2. Methods: The 46 compounds from N. sativa were docked with spike protein using Molecular Operating Environment (MOE) software and compared with commercially available anti-viral drugs e.g., Arbidol, Favipiravir, Remdesivir, Nelfinavir, Chloroquine, Hydroxychloroquine. The Molecular Dynamic Simulation (MDS) analysis was also applied to determine ligand-protein complex stability. Furthermore, the pharmacological properties of compounds were also analyzed using AdmetSAR and SwissADME. Results: Out of its total 46 ligands, 8 compounds i.e., Methyl stearate, Eicosadienoic acid, Oleic acid, Stearic acid, Linoleic acid, Myristoleic acid, Palmitic acid, and Farnesol were selected for further analysis based on their minimum binding energy ranges from -7.45 to -7.07 kcal/mol. The docking scores of N. sativa phytocompounds were similar to drugs taken as control. Moreover, post simulation analysis of Methyl stearate complex predicted the most stable conformer. Conclusions: Further, in-vivo experiments are suggested to validate the medicinal use of Methyl stearate as potential inhibitors against spike protein of SARS-CoV-2.