bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH BAHAN BAKU DAN TEKNIK PEWARNAAN TERHADAP VARIABEL KEUANGAN SOUVENIR BARONG PADA BTIKK
Authors: Normal I Nyoman
Published: December 2023

The aims of this research was to determine the effect of changes in raw materials and coloring techniques on the financial variables of biscuit-baked barong souvenirs at BTIKK in 2019. This research method is descriptive quantitative, which data sources are internal and external, both primary and secondary. The analysis techniques are: a standard cost system based on full costing to calculate the cost of goods manufactured, cost-plus pricing to calculate the selling price, and the operating profit margin method to calculate profitability. The results showed that the change in raw material from CN-17 cast mass to BPN-01 cast mass and the coloring technique from underglaze to onglaze could increase financial variables (cost of goods manufactured, selling price, and operating profit margin) of biscuit-baked barong souvenir (l30,0 - w10,0 - h25,0). The effect on the cost of goods manufactured of barong souvenir made of CN-17 mass raw material for underglaze staining, BPN-01 cast mass raw material under underglaze staining, CN-17 cast mass raw material onglaze staining, and BPN-01 cast mass raw material for onglaze staining are increasing respectively 548.76%, 553.64%, 563.88%, and 568.67% respectively compared to biscuit-baked barong  souvenir, because changes in raw materials and / or coloring techniques change the composition and types of raw materials which cost more expensive, time processing takes longer, the cost of colour material is more expensive, and the frequency of burning is increased by two or three times.
KUALITAS PELAYANAN DAN PROMOSI PENGARUHNYA TERHADAP KEPUASAN PELANGGAN PADA AGROWISATA LEBAH ETNO BALI FOUNDATION DI DESA BAHA MENGWI
Authors: Komang Juniasih Ida Ayu , Radendra Suastama Ida Bagus , Oka Dharma Putu Dananjaya
Published: December 2023

Agrotourism is an activity related to tourism activities which is also a lesson for tourists to get to know more about the production process in the agricultural sector and make the agricultural area a place to enjoy agricultural products directly. The purpose of the study was to determine the effect of service quality and promotion on customer satisfaction at the Bali Foundation's Ethno Bees Agrotourism. The types of data used in this study are qualitative data and quantitative data, with data sources namely primary data and secondary data. Methods of collecting data by means of observation, interviews, documentation and questionnaires.  The results showed that there was a positive and significant influence between service quality and promotion on customer satisfaction, which means that the higher the service and promotion quality, the higher the customer satisfaction. In this case, every improvement in service quality and promotion will increase customer satisfaction. In addition, there is a positive and significant influence between service quality and promotion simultaneously on customer satisfaction at the Bali Foundation's Ethno Bee Agrotourism in Baha Mengwi Village.
PELATIHAN KEAHLIAN DAN PENERAPAN TEKNOLOGI IT BERPENGARUH TERHADAP KINERJA KARYAWAN PT. TELKOM INDONESIA,Tbk UNIT GES WITEL DENPASAR
Authors: Suputra Gumi Wiryawan , Chandra Adnyani Ni Putu
Published: December 2023

Professional human resource management is one of the important aspects in the company. There are several indicators that can affect human resources, namely training, development, performance, and job satisfaction. Not only human resource management, one of the factors that can affect the internal and external success of a business or business and increase productivity and employee performance is the existence of information technology. The purpose of this study was to analyze the effect of skills training on employee performance, to analyze the effect of IT technology on employee performance and to analyze IT skills and technology training on employee performance at PT. Telkom Indonesia, Tbk Unit GES Witel Denpasar. The types of data used in this study are qualitative and quantitative data, with the data source being primary data. The data collection method was carried out by distributing questionnaires to the respondents, while the data analysis techniques used were: classical assumption test and hypothesis testing. The results showed that IT skills and technology training had a significant effect on employee performance at PT. Telkom Indonesia, Tbk Unit GES Witel Denpasar.
STRATEGI PEMASARAN UMKM DI TENGAH PANDEMI COVID-19 (STUDI KASUS PADA BENETREE COFFEE, DENPASAR)
Authors: Lasmini Ni Ketut , Narti Ni Ketut , Sanjaya Ida Bagus , Widiantari KD Nindiana
Published: December 2023

This study aims to determine the company's strengths, weaknesses, opportunities, and threats and to find out the right marketing strategy to be applied to Benetree Coffee. The research was conducted for 3 months, starting from January - March 2021 at Benetree Coffee. The research method used is descriptive qualitative and quantitative. While the analytical tools used are SWOT analysis with IFAS (Internal Factor Analysis Summary) matrix, EFAS (External Factor Analysis Summary) matrix, IE matrix (Internal External), SWOT matrix. The results of the IFAS matrix analysis are 2.897 which indicates that the company's internal position is strong. The results of the EFAS matrix analysis are 2,774. The results of the mapping on the IE matrix show that Benetree Coffee in the marketing strategy occupies position V. This indicates that Benetree Coffee is in a growth position. The results of the SWOT matrix show that there are 11 alternative strategies that can be done by company.
PROSEDUR STANDAR OPERASIONAL PEMESANAN PAKET WISATA PELAYARAN DI LE PIRATE EXPLORE CRUISE-LABUAN BAJO
Authors: Setiyarti Tettie , Eka Safitri Ni Putu , Sundari Pipit
Published: December 2023

When serving guests, the Reservation Department of a shipping company must be provided with guidelines, work references (sequence), and training in providing services. All forms of work guidelines and references are then referred to as Standard Operating Procedures (hereinafter abbreviated as SOP). On this article, based on the research that has been carried out, the author wants to explain in more detail, using a qualitative descriptive research method, regarding the SOP of the Reservation Department at Le Pirate Explore Cruise â€“ Labuan Bajo. The research that forms the basis of this article was carried out in the first and second quarters of 2021, at a time when Bali and East Nusa Tenggara had not yet fully opened their tourism activities. Based on the findings, the research divides the process of implementing the Standard Operating Procedures (SOP) of the Reservation Department into three main thematic, namely: 1) the role of the Owner in making and supervising PSO Reservations; 2) Reservation Department staff behavior; and 3) obstacles faced by the Reservation Department in implementing PSO.
PERUBAHAN UNDANG-UNDANG NOMOR 22 TAHUN 2019 (TENTANG SISTEM BUDIDAYA PERTANIAN BERKELANJUTAN) OLEH UNDANG-UNDANG NOMOR 11 TAHUN 2020 TENTANG CIPTA KERJA DAN PREDIKSI IMPLIKASINYA
Authors: Radendra Suastama Ida Bagus , Komang Juniasih Ida Ayu
Published: December 2023

This study aims to find out which provisions in Law Number 22 of 2019 concerning Agricultural Cultivation Systems were amended by the "Job Creation Law" (Law Number 11 of 2020). This research also aims to find out and understand the rationale and intent underlying the changes made by the Job Creation Law to Law Number 22 of 2019 concerning the Agricultural Cultivation System (hereinafter simply referred to as the Agricultural Cultivation System Law). This research further attempts to estimate predictions related to the implications of these changes by understanding the contents of the new provisions and comparing them with the contents of the amended provisions. This research data collection method is a research method / literature study, especially on primary legal materials, namely laws and regulations. The type of approach and analysis method used in this research is a qualitative approach. The definition of research with a qualitative approach is research that focuses attention on the ideas or values that underlie an act or action of the actor or an event that is related or arises or which is a consequence or result / product of the act / action. The conclusions of this study are: 1. The articles of Law Number 22 of 2019 concerning the Sustainable Agricultural Cultivation System as amended through the Job Creation Act (especially Article 31 of the Job Creation Law) are: Article 19, Article 22, Article 32, Article 43, Article 86, Article 102, and Article 108 of the Law on Sustainable Agricultural Cultivation Systems (Law Number 22 of 2019), as well as the abolition of Article 111 of Law Number 22 of 1999 concerning Sustainable Agricultural Cultivation Systems. 2. The rationale for the amendment of several laws, judging from the comparison between the old provisions and the new provisions of the amended article (comparison between the sound of the articles before and after the amendment), is the idea of providing a legal basis for the Central Government and/or Regional Governments to adopt certain policies or take certain actions related to Agriculture in order to increase Indonesia's attractiveness for investment, business and industry. 3. Things that are expected to occur after the enactment of the Job Creation Act which changes quite a number of laws to increase the attractiveness of Indonesia's investment, is the higher investor confidence and the sense of security of investors to invest in Indonesia, which in turn is expected to increase as well. the value and volume of investment from investors / business people, both from within the country and abroad.
Pengaruh harga dan kualitas produk terhadap keputusan pembelian produk snack french fries pt. siantar top di nusa dua
Authors: Widyanasari Dessy , Derisyani Dian
Published: December 2023

This study aims to analyze and want to know the magnitude of the influence of price and product quality on purchasing decisions for French Fries products, besides that it also wants to know the price comparison of other products, namely Bee Kris snack. This type of research uses a quantitative approach. The method of data collection in this study uses a questionnaire. The measurement scale used in this study is the Likert scale. The analytical technique used is descriptive statistical analysis and normality analysis technique consisting of f test and t test. The data in this study were processed using For Windows SPSS 21
MEMBANGUN CUSTOMER VALUE PADA INDUSTRI PARIWISATA BALI (Suatu Pendekatan Kualitas Pelayanan, Citra, Kepuasan dan Loyalitas Wisatawan)
Authors: Seri Astini Ni Nyoman , Gede Udiyana Ida Bagus
Published: December 2023

This study analyze about developing the customer value on the industry of tourism bali. The aim of this study is to discover the role and the relation among the customer value and the quality of service, the image, satisfaction and tourist loyality. The methodology of this study consist of library research, all the data source are secondary data such as books, journals, and newspapers.
Escola e esfera pública
Authors: Emiliano Batista Douglas
Published: December 2023

O tema deste artigo é a possível relação entre o discurso pedagógico centrado no aluno e a desinformação. O que se objetiva aqui é mostrar que tal discurso pedagógico pode ter levado à “formação” de alunos porosos à desinformação, ao irracionalismo, à polarização etc. O método de pesquisa empregado foi o teórico e bibliográfico. E a fundamentação conceitual deste artigo se deu a partir da Psicanálise e Educação. O principal resultado obtido se relaciona com a concepção de que a pedagogia centrada no aluno, desde as primeiras décadas do século XX, pode ter centrado narcisicamente o aluno em si mesmo, o que teria ocorrido em função da marginalização do professor, bem como de sua autoridade e alteridade em face dos aprendizes. Além disso, as revoluções tecnológicas endossaram, a partir dos anos 60, tal marginalização docente na escola ao pressupor que a iniciativa do aluno de opinar ferozmente a respeito de tudo seria a expressão mais icônica do dito protagonismo discente. Em face disso, conclui-se aqui que o ensimesmamento narcísico e opiniático dos alunos pode ter sido propício à contemporânea difusão de desinformações, de “teorias” conspiratórias irracionalistas e de pós-verdades, e as quais vêm parasitando – e até mesmo erodindo – a esfera pública.
A política de gestão, responsabilização e testagem na rede estadual de ensino do Amazonas
Authors: Silva Josemar Farias da , Oliveira Selma Suely Baçal de
Published: December 2023

O artigo tem como objetivo analisar um conjunto de propostas e ações organicamente articuladas, desenvolvidas no âmbito da rede estadual de ensino do Amazonas que se denominou como uma Política de Gestão, Responsabilização e Testagem. As contribuições teórico-metodológicas do materialismo histórico e dialético guiaram o percurso da análise documental. Desse modo, observa-se o movimento de disputa pela hegemonia da escola pública, que baseado no paradigma da qualidade total em educação, se materializa a partir da implementação de sistemas de testagem em larga escala, como principal mecanismo de aferição da qualidade educacional. Os resultados mostram que a agenda do capital financeiro para a educação no Amazonas configura-se como um grande mercado a ser explorado, considerando as contradições e antagonismos de uma sociedade de classes ao qual a escola está inserida.
Efeito sedativo, físico e comportamental produzido por subdose de metadona no acuponto Yin Tang de gatos
Authors: Guirro Erica Cristina Bueno do Prado , Ribeiro Eduarda , Waterkemper Nadine , Mocellin Lucas Dill , Wolfran Luciana , Thomas Letícia D. , Fukushima Fabiola Bono , Mariani Luiza Prado Ricardo dos Santos
Published: December 2023

A acupuntura é uma técnica chinesa milenar na qual os acupontos são estimulados por agulhas. A estimulação de acupontos por fármacos denomina-se farmacopuntura e o uso de subdoses reduz os efeitos colaterias. A metadona é um opioide sintético capaz de promover boa analgesia e sedação leve. O objetivo deste estudo foi verificar o efeito sedativo, físico e comportamental produzido por subdose de metadona administrada no acuponto Yin Tang de gatos. Esse foi um estudo prospectivo, randomizado e duplo-cego. Foram utilizados 36 gatos hígidos, de 21,8 ± 13,4 meses e com peso de 3,6 ± 0,9 kg. Após 60 minutos de adaptação ao ambiente, em T0 (tempo zero) os gatos foram submetidos à avaliação basal de frequência cardíaca (FC), frequência respiratória (FR), pressão arterial sistólica não invasiva, temperatura retal, diâmetro pupilar, presença de sialorreia, náusea, vômito, excitação, vocalização, exposição de 3ª pálpebra e escore de sedação. Realizou-se, então, os tratamentos conforme o grupo experimental, sendo G1 (n = 7): 0,05 ml de NaCl 0,9% no acuponto Yin Tang e 0,05 ml de NaCl 0,9% SC; G2 (n = 7): 0,05 ml de NaCl 0,9% no acuponto Yin Tang e 0,05 mg/kg de metadona SC; G3 (n = 7): 0,05 ml de NaCl 0,9% no acuponto Yin Tang e 0,10 mg/kg de metadona SC; G4 (n = 8): 0,05 mg/kg de metadona no acuponto Yin Tang e 0,05 ml de NaCl 0,9% SC; e G5 (n = 7): 0,10 mg/kg de metadona no acuponto Yin Tang e 0,05 ml de NaCl 0,9% SC. Houve reavaliação dos parâmetros em T10min, T20min, T30min, T40min, T50min e T60min. Os dados paramétricos foram submetidos à ANOVA de uma via seguida por Tukey, enquanto os dados não paramétricos foram submetidos à Kruskal Wallis, sempre com p < 0,05. Não observou-se variação significativa de FC, pressão arterial sistólica, exposição de 3ª pálpebra e escore de sialorreia, náusea, vômito, excitação e vocalização. Houve variação sutil e transitória de FR, temperatura retal e de diâmetro pupilar. Em relação à sedação, observou-se que entre tempos o escore de G4 em T0 foi menor que em T40; e em G5 o escore de T20, T30 e T40 foi superior ao verificado em T0, T10, T50 e T60. Entre grupos, em T0, T10, T50 e T60 não houve variação significativa, todavia, em T20, T30 e T40, o escore de G4 e G5 foi superior ao apresentado por G1, G2 e G3. Esses achados evidenciaram que as subdoses de metadona no Yin Tang praticamente não interferiram parâmetros físicos e comportamentais, mas foram capazes de promover sedação leve. Assim, conclui-se que subdoses de metadona (0,05 ou 0,10 mg/kg) aplicadas no Yin Tang de gatos promovem sedação leve isenta de efeitos colaterais. O protocolo com 0,10 mg/kg é mais efetivo.
Acupuntura aplicada para reabilitação oral de cão submetido à mandibulectomia total bilateral – Relato de caso
Authors: Ferreira Camilla , Ribeiro Thayana Queiroz , Capriglione Luiz Guilherme Achcar , Michelotto Junior Pedro Vicente , Mariani Luiza Prado Ricardo dos Santos
Published: December 2023

As neoplasias têm grande incidência em animais de companhia em vários países e a depender do grau de malignidade, cirurgias curativas são frequentes. As margens necessárias para a completa excisão tumoral, bem como o tamanho do tumor, vão influenciar no quão agressivo será o procedimento. Nesse contexto, a reabilitação desses pacientes é de extrema importância para a adaptação e qualidade de vida no pós-operatório dos pacientes e de seus tutores. Esse relato de caso discorre sobre a reabilitação de um Golden Retriever, submetido à uma mandibulectomia total bilateral utilizando a acupuntura como meio de reabilitação. Considerando a alta complexidade do procedimento cirúrgico e a dificuldade da paciente voltar a se alimentar no pós-operatório, a acupuntura foi de grande relevância em sua recuperação, visto que a sonda de faringostomia não pôde ser retirada para que fosse possível manter a necessidade energética da paciente. Portanto a acupuntura se mostrou eficaz e de extrema importância física, emocional e psicológica no auxílio ao retorno parcial da alimentação, melhorando sua qualidade de vida e dos tutores.
Uso de terapia integrativa em caso de paralisia facial em muar – Relato de caso
Authors: Santi Thasla de Freitas , Mariani Luiza Prado Ricardo dos Santos , Capriglione Luiz Guilherme Achcar
Published: December 2023

Na medicina equina, a lesão em nervo facial é relativamente corriqueira, sendo a sua maior incidência devido a traumas e/ou compressões na região do músculo masseter. O tratamento clínico pode ser instituído junto com a terapia complementar, como a prática de acupuntura e eletroestimulação. Este resumo tem como objetivo relatar o caso de um burro de um ano de idade, o qual, ao sair da cocheira, cortou a região do músculo masseter do lado esquerdo. O animal foi sedado a fim de visualizar melhor a extensão e profundidade do corte, evidenciando lesão corto-contusa na região mandibular. Instituiu-se tratamento com dexametasona (2,5 mg/kg por via intravenosa por oito dias) e vitamina B12 (2.000 mcg/kg por cinco dias por via intramuscular). Sem sucesso, optou-se por realizar terapia complementar com acupuntura e eletroestimulação por meio da transcutaneous electrical nerve simulation (TENS). Ao iniciar as sessões, no exame físico pôde-se observar a paralização da região da narina e lábio, voltados para o lado direito, atingindo apenas o ramo bucal ventral do nervo facial. Foram realizadas cinco sessões de acupuntura com intervalo de dois dias, empregando-se o agulhamento seco nos acupontos estômago (E)-7, E-4, intestino grosso (IG)-20, triplo aquecedor (TA)-17 e IG4 (ponto mestre da face e boca), com agulhas de acupuntura 0,25 x 15mm. A eletroestimulação com TENS foi realizada em 250Hz no modo pulsado por 15 minutos, a cada dois dias, por dez dias. Associado às terapias, solicitou-se o uso de uma rede de feno, a fim de estimular diariamente a região paralisada ao animal procurar o feno para se alimentar. Ao final das cinco sessões, pôde-se observar uma grande melhora na região das narinas e lábio superior, que estavam centralizadas. Conclui-se que o uso da acupuntura como terapia complementar se mostrou eficaz neste caso de paralisia do nervo facial, uma vez que contribuiu para a centralização da região das narinas e lábio superior após as sessões de acupuntura.
Autonomia e dependência como posicionamentos: uma contribuição para uma ética do cuidado
Authors: Vilar Stella Crivellenti , Amorim Katia de Souza , Guanaes-Lorenzi Carla
Published: December 2023

O discurso social sobre o cuidado (care) levanta questionamentos relacionados desde o contexto político e social em que este se dá à micropolítica das interações. Sobre esta questão, abre-se a discussão sobre o posicionamento ético do cuidador, que pode atuar de maneira autoritária em relação à pessoa cuidada, considerada desprovida de autonomia. Este princípio é entendido como limitante às possibilidades de direitos da pessoa cuidada quando em condição de dependência. Abordando a questão de forma crítica, à luz de do construcionismo social e da fenomenologia, a presente reflexão contribui para a discussão epistemológica sobre dependência e autonomia especialmente no cuidado de idosos. Constatam-se possibilidades efetivas para a pessoa cuidada exercer sua autonomia. Nota-se como esta autonomia pode emergir através das relações com os cuidadores e da responsividade destes, principalmente por meio da corporeidade, em detrimento da linguagem verbal e racional.
Qualidade de vida em adultos com transtorno déficit de atenção e hiperatividade
Authors: Batista Von Borowski Sílvia , Da Silva Rizzatti Letícia , Machado Lopes Fernanda
Published: December 2023

O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) afeta, além de crianças, muitos adultos. Gera grande impacto na vida desses indivíduos, resultando em dificuldades acadêmicas, profissionais, sociais e emocionais. O objetivo deste estudo foi descrever os níveis de qualidade de vida (QV) em brasileiros diagnosticados com TDAH em acompanhamento psicoterapêutico e/ou farmacológico. Participaram 106 adultos, os quais responderam um questionário sociodemográfico e à Escala de Satisfação com a Vida WHOQOL – Bref.  O perfil sociodemográfico dos participantes deste estudo, contrário à maior parte da literatura, foi de pessoas com alta escolaridade e empregadas. Apesar disso, a maioria deles percebe seu nível de QV como baixo, pois 40,6% referiu que está regular e 28,3% que precisa melhorar, comparado com os que percebem como bom (29,2%) ou muito bom (1,9%). Tal constatação suscita a discussão sobre a eficácia e efetividade do tratamento e o alinhamento deste com os valores e metas dos pacientes. Recomenda-se que os profissionais de saúde atentem para o custo emocional nos processos de manutenção de rotinas, trabalho e expectativas de bem-estar dos pacientes. Além disso, que façam uma avaliação periódica dos déficits e potencialidades para um plano de tratamento direcionado às características e necessidades que suscitem melhor percepção de QV por parte dos indivíduos com TDAH.
O conhecimento em Avaliação Psicológica para os Estudantes de Graduação
Authors: Sousa Rocha André
Published: December 2023

Este estudo objetivou investigar o conceito de avaliação psicológica em estudantes de graduação. Participaram 87 universitários, 65,3% se declararam do sexo feminino, de uma faculdade no estado do Ceará, de semestres variados. Utilizou-se um questionário sociodemográfico e um questionário contendo seis perguntas abertas acerca da avaliação psicológica. Os dados foram analisados no software iramuteq por meio de duas técnicas: Nuvem de Palavras e Classificação Hierárquica Descendente (CHD). A CDH indicou a existência de três classes, que enfatizam a avaliação psicológica: conceitos e instrumentos utilizados (classe 1), parâmetros psicométricos dos instrumentos psicológicos (classe 2) e Satepsi: requisitos mínimos de autorização para uso do teste psicológico (classe 3). Conclui-se que a função do satepsi e a noção da avaliação psicológica foram compreendidas. Contudo, os aspectos psicométricos são pouco assimilados. Desse modo, é preciso repensar em técnicas e recursos de ensino que possam contribuir para a melhoria da formação.
Geopolymer Binder for the Production of Sustainable Alternative Building Materials
Authors:   , Vītola Laura
Published: December 2023

In the Doctoral Thesis, geopolymer binders corresponding to the European Green Deal have been developed, and their properties investigated. The properties of geopolymer binders are characterised depending on the composition, temperature and mixing time of the composition, as well as the presence of zeolites in the composition. The mechanical and physical properties of geopolymer binders were determined, the microstructure was studied, the chemical and mineralogical composition was determined, and their suitability for the production of bio-composites was characterised.
Determination of consciousness, self-consciousness and subjectness within the framework of the information concept
Authors: Gribkov Andrei Armovich , Zelenskii Aleksandr Aleksandrovich
Published: December 2023

The article is devoted to the study of the nature of consciousness within the framework of the information concept. The paper proposes a definition of consciousness as an informational environment in which an extended model of reality is realized. The process of realization of this extended model is defined as thinking. The result of thinking is information objects that form a system in the form of information environment. Information objects are reflections of the real world properties, not directly, but by means of translation through a special object – a carrier of consciousness. In the case of human consciousness, such a carrier is a human being (represented in the form of his nervous system). As a result, consciousness can be qualified as a simulacrum of reality, i.e., a model of a model: an information model of the carrier of consciousness, which in turn is a means of physical modeling of the real "big" world. Possible mechanisms mediating thinking are considered. For this purpose, two new concepts are introduced: neural circuit and neurophysical pattern. An approach to the study of self-consciousness based on the localization of the consciousness carrier in the multidimensional space of states of initial real objects, as well as their reflections in the form of information objects is proposed. This localization is ensured by the presence of feedbacks. Summarizing the results of the study, the article states the following connection between consciousness, self-consciousness and subjectness: under certain conditions (when consciousness is localized in the state space of the carrier of consciousness), consciousness acquires the property of self-consciousness, a special case of which (when the initiator of changes determining localization is the carrier of consciousness) is self-consciousness endowed with subjectness.
A unified approach to dissecting biphasic responses in cell signaling
Authors: Ramesh Vaidhiswaran , Krishnan J
Published: December 2023

Biphasic responses are encountered at all levels in biological systems. At the cellular level, biphasic dose-responses are widely encountered in cell signaling and post-translational modification systems and represent safeguards against overactivation or overexpression of species. In this paper, we provide a unified theoretical synthesis of biphasic responses in cell signaling systems, by assessing signaling systems ranging from basic biochemical building blocks to canonical network structures to well-characterized exemplars on one hand, and examining different types of doses on the other. By using analytical and computational approaches applied to a range of systems across levels (described by broadly employed models), we reveal (i) design principles enabling the presence of biphasic responses, including in almost all instances, an explicit characterization of the parameter space (ii) structural factors which preclude the possibility of biphasic responses (iii) different combinations of the presence or absence of enzyme-biphasic and substrate-biphasic responses, representing safeguards against overactivation and overexpression, respectively (iv) the possibility of broadly robust biphasic responses (v) the complete alteration of signaling behavior in a network due to biphasic interactions between species (biphasic regulation) (vi) the propensity of different co-existing biphasic responses in the Erk signaling network. These results both individually and in totality have a number of important consequences for systems and synthetic biology.
Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level
Authors: Yamaguchi Atomu , Maeshige Noriaki , Noguchi Hikari , Yan Jiawei , Ma Xiaoqi , Uemura Mikiko , Su Dongming , Kondo Hiroyo , Sarosiek Kristopher , Fujino Hidemi
Published: December 2023

The regulation of inflammatory responses is an important intervention in biological function and macrophages play an essential role during inflammation. Skeletal muscle is the largest organ in the human body and releases various factors which mediate anti-inflammatory/immune modulatory effects. Recently, the roles of extracellular vesicles (EVs) from a large variety of cells are reported. In particular, EVs released from skeletal muscle are attracting attention due to their therapeutic effects on dysfunctional organs and tissues. Also, ultrasound (US) promotes release of EVs from skeletal muscle. In this study, we investigated the output parameters and mechanisms of US-induced EV release enhancement and the potential of US-treated skeletal muscle-derived EVs in the regulation of inflammatory responses in macrophages. High-intensity US (3.0 W/cm2) irradiation increased EV secretion from C2C12 murine muscle cells via elevating intracellular Ca2+ level without negative effects. Moreover, US-induced EVs suppressed expression levels of pro-inflammatory factors in macrophages. miRNA sequencing analysis revealed that miR-206-3p and miR-378a-3p were especially abundant in skeletal myotube-derived EVs. In this study we demonstrated that high-intensity US promotes the release of anti-inflammatory EVs from skeletal myotubes and exert anti-inflammatory effects on macrophages.
Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a
Authors: Cullinan Megan M , Klipp Robert C , Camenisch Abigail , Bankston John R
Published: December 2023

Acid-sensing ion channels (ASICs) are trimeric proton-gated sodium channels. Recent work has shown that these channels play a role in necroptosis following prolonged acidic exposure like occurs in stroke. The C-terminus of ASIC1a is thought to mediate necroptotic cell death through interaction with receptor interacting serine threonine kinase 1 (RIPK1). This interaction is hypothesized to be inhibited at rest via an interaction between the C- and N-termini which blocks the RIPK1 binding site. Here, we use two transition metal ion FRET methods to investigate the conformational dynamics of the termini at neutral and acidic pH. We do not find evidence that the termini are close enough to be bound while the channel is at rest and find that the termini may modestly move closer together during acidification. At rest, the N-terminus adopts a conformation parallel to the membrane about 10 Å away. The distal end of the C-terminus may also spend time close to the membrane at rest. After acidification, the proximal portion of the N-terminus moves marginally closer to the membrane whereas the distal portion of the C-terminus swings away from the membrane. Together these data suggest that a new hypothesis for RIPK1 binding during stroke is needed.
Pharmacoscreening, molecular dynamics, and quantum mechanics of inermin from Panax ginseng: a crucial molecule inhibiting exosomal protein target associated with coronary artery disease progression
Authors: V Janakiraman , M Sudhan , Wani Abubakar , Ahmad Sheikh F. , Nadeem Ahmed , Sharma Ashutosh , Ahmed Shiek S. S. J.
Published: December 2023

Background

Exosomes, microvesicles, carry and release several vital molecules across cells, tissues, and organs. Epicardial adipose tissue exosomes are critical in the development and progression of coronary artery disease (CAD). It is hypothesized that exosomes may transport causative molecules from inflamed tissue and deliver to the target tissue and progress CAD. Thus, identifying and inhibiting the CAD-associated proteins that are being transported to other cells via exosomes will help slow the progression of CAD.

Methods

This study uses a systems biological approach that integrates differential gene expression in the CAD, exosomal cargo assessment, protein network construction, and functional enrichment to identify the crucial exosomal cargo protein target. Meanwhile, absorption, distribution, metabolism, and excretion (ADME) screening of Panax ginseng-derived compounds was conducted and then docked against the protein target to identify potential inhibitors and then subjected to molecular dynamics simulation (MDS) to understand the behavior of the protein-ligand complex till 100 nanoseconds. Finally, density functional theory (DFT) calculation was performed on the ligand with the highest affinity with the target.

Results

Through the systems biological approach, Mothers against decapentaplegic homolog 2 protein (SMAD2) was determined as a potential target that linked with PI3K-Akt signaling, Ubiquitin mediated proteolysis, and the focal adhesion pathway. Further, screening of 190 Panax ginseng compounds, 27 showed drug-likeness properties. Inermin, a phytochemical showed good docking with −5.02 kcal/mol and achieved stability confirmation with SMAD2 based on MDS when compared to the known CAD drugs. Additionally, DFT analysis of inermin showed high chemical activity that significantly contributes to effective target binding. Overall, our computational study suggests that inermin could act against SMAD2 and may aid in the management of CAD.
Experiências e percepções dos consumidores de restaurantes: um estudo exploratório
Authors: Levistsk Vanessa Carolina Brante , De Oliveira Alessandro Silva
Published: December 2023

O setor de restaurantes no Brasil ocupa um papel importante na economia e na geração de emprego. Cabe aos restaurantes atenderem uma demanda crescente de pessoas que consomem fora do lar. No entanto, é importante que os gestores dos restaurantes se preocupem em oferecer experiências de consumo agradáveis e memoráveis por meio de produtos e serviços de qualidade para torná-los leais. Assim, o objetivo desse trabalho é realizar um estudo qualitativo e exploratório, que visa identificar algumas experiências e percepções dos consumidores de restaurantes. Para a concretização desse objetivo foi realizado uma revisão de literatura seguida de comentários postados por consumidores que frequentaram restaurantes em Campo Grande – MS. Essas postagens são comentários públicos disponíveis no site de busca Google. As temáticas comportamentais dos consumidores que foram abordadas, contemplam a qualidade percebida, experiência de consumo e a lealdade do consumidor. Por meio das postagens de alguns clientes de restaurantes, ficou evidenciado que eles tiveram uma ótima experiência ao consumirem certos tipos de comidas. Para outros consumidores as experiencias foram tão impactantes que não tinham palavras para descrever e que o lugar ficaria gravado em suas memórias. Cabe ressaltar que este é um trabalho exploratório, dessa forma não há resultados conclusivos que podem ser generalizados.
Effect of 4 microalgal diets on the proximal composition, chlorophyll concentration, and total carotenoid content in Artemia franciscana
Authors: Millán-Almaraz Martha Irene , López-Peraza Diana J , Nieves-Soto Mario , Peraza-Yee Mario M
Published: December 2023

Microalgae are the primary source of food for Artemia franciscana. In turn, Artemia serve as live food for various species in culture. The chemical composition of Artemia is of great importance because it affects the nutritional quality of the organisms produced in aquaculture systems. For this reason, the present study aimed to characterize the nutritional value, proximal composition, concentration of chlorophyll a and b, and total carotenoid content in the microalgae Thalassiosira weissflogii, Chaetoceros muelleri, Tetraselmis suecica, and Nannochloropsis sp., which were used to feed juvenile A. franciscana for 6 h. Artemia juveniles fed with these microalgae species exhibited higher concentrations of proteins, carbohydrates, lipids, chlorophyll a and b, and total carotenoids than those in the control. The organisms fed with Tetraselmis suecica presented the highest content of chlorophyll b, while those fed with Thalassiosira weissflogii and Chaetoceros muelleri showed the highest values of total carotenoids and chlorophyll a.
Effect of Vestibular Rehabilitation on Sleep Quality and Depression in the Elderly With Chronic Dizziness: A Prospective Study
Authors: Dastgerdi Zahra Hosseini , Gohari Nasrin , Mehrabifard Mobina , Seifi Hasti , Khavarghazalani Bahare
Published: December 2023

Background and Objectives: Dizziness and the accompanying complaints, including sleep disorders and depression, are common among the elderly. This study investigated the effect of vestibular rehabilitation on complaints of dizziness, sleep problems, and the severity of depression in older people with chronic dizziness.Subjects and Methods: The study included 25 participants with chronic dizziness accompanied by comorbid sleep disturbance (Pittsburgh Sleep Quality Index [PSQI] global score >5). Participants completed the Dizziness Handicap Inventory (three sub-scales: physical, emotional, and functional), the PSQI, and the Persian version of the shortened Beck Depression Inventory (BDI-13) before and after the vestibular rehabilitation.Results: The findings showed that the handicap caused by dizziness, the severity of depression, and the quality of sleep in the study participants improved significantly after the intervention (p<0.05).Conclusions: Vestibular rehabilitation is an effective intervention to reduce dizziness handicap, comorbid sleep disturbance, and depression.
Combination Therapy of Choline Alfoscerate With Ginkgo biloba Monotherapy in Age-Related Hearing Loss: Effects and Outcomes
Authors: Kim Dae Hyun , Seo Young Joon
Published: December 2023

Background and Objectives: Ginkgo biloba and choline alfoscerate are used as adjuvant treatment for presbycusis, but studies on how the monotherapy differs from the combination therapy are lacking. Therefore, this study aimed to compare the audiologic outcomes between Ginkgo biloba monotherapy and Ginkgo biloba and choline alfoscerate combination therapy.Subjects and Methods: The study groups are divided into three: negative control, monotherapy, and combination therapy groups. All groups’ pure tone audiometry was measured by dividing the study period into Initial, 3-6, 6-9, 9-12, 12-15 months, and checked whether differences between groups were present.Results: The combination therapy showed less gradient gap than the monotherapy, indicating less hearing loss rate than the monotherapy. Based on the Kaplan–Meier curve, the combination therapy showed better results in terms of survival time of hearing.Conclusions: As a pharmacological treatment for presbycusis, combination therapy shows better results than monotherapy.
Incorporation of Technology in the Mathematics Classroom: A Review of its Extent in Ghana's Educational Landscape
Authors: Atteh Evans , Boadi Augustine , Amoah Esther
Published: December 2023

In the early stages, humans exhibited apprehension towards interacting with computers, however presently, the majority of individuals possess the ability to effectively utilize computers and their associated functionalities. The incorporation of technology in the field of mathematics extends beyond basic tasks such as typing and printing questions or delivering courses using PowerPoint. Instead, it involves utilizing technology to effectively educate learners on a wide range of mathematical concepts and topics. The incorporation of technology in mathematics education yields beneficial outcomes for both the instruction and acquisition of mathematical concepts.  Hence, it is imperative for educators in the field of mathematics to include technology into their instructional practices, while also fostering a culture that promotes the utilization of technology by students for the purpose of enhancing their mathematical learning experiences The aim of the paper is to draw attention to existing literature that examines the integration of technology in math classrooms in Ghana, including the available technologies, their use for teaching math, the competence of math teachers in integrating technology, the relationship between the mathematics curriculum and technology integration, the benefits of technology in developing math concepts, the challenges of teaching with technology, and the implications of incorporating technology in math education.
Comparison of Data Fluctuations that Lead to Cyber Security Attacks: A Difference between Surface, Deep and Dark Net
Authors: Patel Hrishitva
Published: December 2023

The term "darknet" refers to the address space on the internet that is not being used, and users do not anticipate that this area will interact with their machines. Darknet is a source of cyber intelligence. In order to develop network security, it is necessary to conduct studies of the many dangers that comprise the network. In this research, we offer brand new machine learning classifiers that go by the name stacking ensemble learning. Their purpose is to evaluate and categorize darknet traffic. This novel approach employs predictions created by three different base learning techniques in order to deal with the issues relating to darknet attacks. The software was validated using a dataset that had more than 141,000 records and was derived from the CIC-Darknet 2020 database. The findings of the experiment indicated that the classifiers used in the investigation were able to easily differentiate between benign and malignant traffic. The classifiers have the ability to efficiently recognize known as well as unknown threats with a high degree of precision and accuracy that is greater than 99% in the training and 97% in the testing phases, with increments ranging from 4 to 64% based on the algorithms that are currently in use. As a consequence of this, the suggested system will become more reliable and accurate as more data is collected. Additionally, in comparison to other AI algorithms already available, the suggested system has the lowest standard deviation.
Effect of Seed-Borne Mycoflora on Seed Germination and Seedling Vigour of Soybean (Glycine max L.)
Authors: Sahu Suresh Kumar , Vikram  , Sunderrao Raut Ravindra , Sahu Shanta , Sahu Bhavesh Kumar , Tandon Ashwarya L.
Published: December 2023

The present study aimed to investigate the impact of seed-borne mycoflora on soybean (Glycine max L.). Seed germination and subsequent seedling vigour are important factors for influencing crop establishment and yield potential. Six varieties of soybean seed samples viz. JS 95-60, JS 97-52, RSC 10-46, RSC 10-71, CG Soya-1 and seven seed-borne mycoflora viz. Fusarium spp., Alternaria spp., Colletotrichum spp., Cladosporium spp., Macrophomina spp., Penicillium spp. and Trichoderma spp. were selected for the experiment. A pot experiment was conducted to study the effect of seed-borne mycoflora on seed germination and seedling vigour of soybean. The results revealed that, among seed inoculation techniques maximum reduction in seedling vigour index over control was observed in Colletotrichum spp. (27.24%) inoculated seedlings and overall increased seedling vigour of soybean varieties was observed in Trichoderma spp. (26.52%) inoculated seedlings. Among soil inoculation techniques maximum reduction in seedling vigour index over control was observed in Macrophomina spp. (38.41%) inoculated seedlings and overall increased seedling vigour of soybean varieties was observed in Trichoderma spp. (24.40%) inoculated seedlings.
Estimates of Contribution, Claustration and Principal Component Analysis in Different Genotype of Brinjal (Solanum melongena L.)
Authors: Chaudhary Akhil Kumar , Kumar Lav , Kumar Shani , Maurya Rajat Kumar , Kumar Rupesh
Published: December 2023

The present investigation was carried out in thirty-two genotypes of brinjal with a view to estimate the extent of variability, variance and genetic divergence. The experiment was conducted in Randomized Block Design with three replications at Department of Vegetable Science, Acharya Narendra Deva University of Agriculture and Technology Narendra Nagar, (Kumarganj), Ayodhya (U.P.), during Kharif, 2020-21. Each treatment consisted of twelve plants in two rows, having spacing of 60 cm x 50 cm with net plot size of 1.2 m x 3.0 m2. Based on the Principal Component Analysis (PCA) with 15 parameters of cent percent diversity, it formed 6 Principal Components (PCs) with more than one Eigen value. These components indicate maximum variation among the variables with a diversity percentage of 75.46%. The first PC showed 19.59% variation, while the second, third, fourth, fifth and sixth (PCs) showed the variation of 19.18%, 11.48%, 9.37%, 8.29% and 7.54% respectively. Contribution of diverse traits in principal component analysis showed positive and maximum variable loaded component PCI for T.S.S (0.3321), PC II for number of primary branches per plant (0.0.6397), PC III for days to 50 % flowering (0.5158), PC IV for plant height (0.0.592), PC V for day to first fruit harvest (0.4073) and PC VI for day to first fruit harvest (0.5741).
Uma intervenção psicologicamente ética sobre o sujeito aderente a movimento de pureza sexual
Authors: Andrade Almeida Saulo Albert
Published: December 2023

Este trabalho analisa a ética acerca da intervenção da psicóloga na angústia culposa do sujeito sobre a própria libido resultante de participação em movimento evangélico de pureza sexual. O seu embasamento teórico envolve: um resumo sócio-histórico da castidade dentro do cristianismo; uma netnografia que engloba desabafos e relatos compartilhados dentro de comunidades e espaços virtuais evangélicos sobre algumas das modalidades de angústias e sofrimentos atrelados à participação nesse tipo de movimento; e uma análise do código de ética brasileiro da psicologia acerca da questão religiosa. O objetivo é compreender como a psicóloga pode intervir eticamente sobre o sofrimento desse sujeito sem (necessariamente) afastá-lo da sua religião. O resultado almejado é o desenvolvimento de metodologias psicologicamente em consonância com o código de ética da categoria que permitam ajudar esse sujeito a lidar positivamente com a sua própria sexualidade.
Ouvindo a criança transgênero
Authors: Vieira Magnus Daniella , Rosa Cristiano Eduardo da , Felipe Jane
Published: December 2023

Neste artigo objetivamos realizar um mapeamento das produções intelectuais brasileiras que ouviram crianças transgênero em suas investigações a fim de compreender como essa temática está sendo analisada. A pesquisa também discute sobre as demandas e os dilemas que envolvem a transgeneridade infantil e as questões éticas e metodológicas que permeiam as pesquisas com crianças no Brasil. O levantamento foi realizado em plataformas de busca da internet que indexam e disseminam estudos científicos, sendo analisados por meio de uma perspectiva pós-estruturalista. Constatamos que os trabalhos recuperados nas buscas predominantemente fazem reflexões teóricas, baseados em levantamentos bibliográficos e também em memórias acerca da infância de adultos(as) trans. Nesse sentido, consideramos que urge a necessidade de mais estudos com crianças transgênero no país, tensionando como se entende a transgeneridade na infância e que conhecimentos potencialmente podem ser produzidos por esses sujeitos.