bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Results of Food Plant Seed Breeding Training in 2013 on the Development Unit of Food Plant Seeds and Horticulture, West Kalimantan Province
Authors: Umardani Gunawan
Published: June 2021

This study aimed to evaluate the 2013 food plant seed breeding training program that adopts Kirk Patrick's approach by using four levels of evaluation stages, namely Reaction Evaluating, Learning Evaluating, Behavior Evaluating, and Results Evaluating. This study was qualitative descriptive. The research informant was the Head of the Food and Horticultural Plant Seed Development Unit of West Kalimantan Province. The training participants were represented by 7 Heads of Seed Garden Installation, one committee, one instructor as a training facilitator, as well as one farmer breeder who did not participate in the training program. Data collection was carried out through observation and in-deft interview techniques with the informants. The results of descriptive analysis showed that the policy context concerning the objectives to be achieved and the program was considered clear according to the majority of informants and also running well. At the Reaction Stage, most of the informants admitted that the time given was too limited: however, the participants were satisfied with the atmosphere of the Food Plant Seed breeding training activities, the instructor was considered to be competent and mastered the learning media so that he was able to motivate the participants to be active in learning, the committee had also worked optimally. At the Learning Stage, the learning method was presented interestingly yet the participants were not yet fully skillful. At the Behavior Stage, the majority of informants from the participants' group acknowledged that there had been a change in behavior which was shown by the improvement of skills after participating in the Food Plant Seed breeding training program. Finally, at the Yield Stage, after a few months of participating in the breeding training of these food crop seeds, there had been a change in production even though has not been able to exceed the production yield of the breeding farmers who did not participate in the breeding training program of these food crop seeds.
The Utilization of Effective Microorganism 4 (EM4) on Growth of Oil Palm Seedling in Pre Nursery
Authors: Astutik Dwi , Rahhutami Ratih , Handini Aline Sisi , Sutopo Ahmad
Published: June 2021

A planting medium that rich in nutrients is needed for oil palm, especially in the nursery phase. This study aimed to determine the effect of various doses of EM4 and to get the best dose of EM4 on the growth of oil palm seedlings in the pre-nursery. The research method used was a non-factorial completely randomized design with 4 treatments, namely 0 ml EM4 (A1), 4 ml EM4 (A2), 8 ml EM4 (A3), and 12 ml EM4 (A4). Each treatment was repeated 6 times so that there were 24 experimental units. The data obtained were analyzed for variance at the 5% level, if the effect was real, it was followed by the least significant difference (LSD) test. Based on the results of the study, it could be concluded that application of various EM4 doses had a significant effect on plant height (4-12 MST), the number of leaves (4-8 MST), trunk girth (4-12 MST), and shoot wet weight but did not significantly affect the number of leaves (12 MST), the volume of roots, length of roots, root wet weight and shoot dry weight, dry weight root, the best dose was shown at a dose of 12 ml EM4.
Comparison of the Dominance of Internal and External Influences on the Return of Shares of Companies Listed in IDX30
Authors: Arifin Hutama Sanputra , Koroy Tri Ramaraya , Ruwanti Gemi , Arifin Zainal
Published: June 2021

This study aims to determine the comparison of external and internal influences on stock returns on the Indonesia Stock Exchange. The research method uses quantitative methods from secondary data of financial analysis on 16 companies from 30 companies on the IDX Index that have a high level of liquidity and have a large capitalization selected by the IDX (Indonesia Stock Exchange) with several selection criteria, the selection is carried out by the IDX regularly 2 times every year, namely in February and August. from 2014-2018 and data from Bank Indonesia on economic growth and inflation in the same year. The data analysis technique used multiple regression. The results show that the influence of external factors in the form of economic growth and inflation is more dominant than the company's internal factors in the form of DY (Dividend Yield), EPS (Earning Per Share), ROE (Return On Equity), PER (Price Earning Ratio) affect stock returns. Implementation for companies that go public needs to pay attention to the dynamics of environmental changes, especially the inflation rate which can cause investors to sell their shares, while this phenomenon is an opportunity for some investors to get a cheaper share price than many other investors have released.
Pemberian Tepung Singkong yang Ditambahkan Isoamilase dalam Pakan terhadap Performa Ayam Broiler
Authors: Mardiah Rahmadani  , Hermana W , Nahrowi Nahrowi
Published: June 2021

Cassava has the potential use to replace corn as an energy source in poultry feed.However, the level of substitution is not optimal because of the difference ratio ofamylose and amylopectin in maize and cassava. This study aimed to examine the effectof cassava flour with addition of isoamylase as a corn substitute in the ration on theperformance of broilers. The material used in this study was 150 male day-old chickenbroiler which were randomly divided into 3 treatments and 5 replications. Thetreatments were P0: 50% corn in the ration (control); P1: Substitution of 50% of cornby cassava flour; P2: Substitution of 50% of corn by cassava flour which contained0.14% isoamylase. The variables measured were feed intake, body weight, weight gain,feed conversion ratio, income over feed and chick cost and mortality rate. Data from thecomplete randomized design were analyzed using Analysis of Variance, the significantresults between the treatments were obtained by Duncan Multiple Range Test. Theresults showed that the substitution of corn by cassava flour without and with 0.14%isoamylase was not significantly affect final body weight, body weight gain, feed intakeand feed conversion ratio. The most profitable Income over feed cost obtained was thetreatment of P2 that is Rp 6,543.50. It can be concluded that the corn substitution bycassava flour without and with addition of 0.14% isoamylase was able to produce thesame performance as broiler chickens fed with corn in the ration for five weeks of thestudy.

Key words: broiler, isoamylase, cassava flour, performance
Haemorrhagic suprarenal pseudocysts: a systematic review of a rare condition from family physicians’ perspective during the COVID-19 global pandemic
Authors: Olowu Adekunle , Alzehairy Adel Abbas
Published: June 2021

Adrenal cysts are rare lesions that could be epithelial, endothelial, parasitic or haemorrhagic[1], as well as pseudocysts. Haemorrhagic adrenal cysts are extremely rare and are often asymptomatic, so diagnosis can be really challenging. This can prove really difficult for primary care physicians who are often the frontline clinicians these patients tend to present to. They are usually benign lesions and do not often cause mortality if detected early and prompt surgery is done, as was the case with the patient in our case report[4]. When they do become symptomatic, they can present with different systemic symptoms as documented in literature, including in our case report[2,4]. Diagnosis is usually through Ultrasound and CT Scan and management is largely laparoscopic or open excision depending on the size of the lesion, surgical expertise and local protocol. Most patients make full recovery and mortality is extremely low [3]. The aim of this review is to provide a broader overview of the subject, highlight salient points in several studies relating to haemorrhagic cysts, provide an up to date follow up information on the index patient in our case report and to explore possible areas for future study [4,6]. This review also includes a suggested management algorithm and intends to emphasize the fact that patients who present in primary, urgent or emergency care settings with persistent non-specific symptoms should be investigated for rare diseases.
Study of physicochemical, functional, particle size and fermentation properties of flours composed of wheat and young shoots of palmyra palm in the perspective of the preparation of compound bread
Authors: Michel Arthur Niamke  , Abdoulaye Toure  , Soronikpoho Soro  , Jaurès Elidjé Atchowo  , Joseph Allico Djaman
Published: June 2021

This study on wheat flour type 55, the flour of young shoots of Palmyra palm (Borassus aethiopum Mart.), the mixture of the two (2) flours containing 5%, 10%, 15%, 20%, 25% of flour of young shoots of the palmyra palm, is an enhancement of the young shoots of the palmyra palm, a tuber little transformed in Côte d'Ivoire. The study on the physicochemical properties of the different flours revealed that the incorporation of the flour of young shoots of palmyra palm in the compound flours increased the content of reducing sugars, total sugars and especially fibers, which is beneficial for the health of populations ; the lipid and ash contents of wheat flour and of compound flour are not significantly different at the 5% threshold; the bulk density contents of all the flours are not significantly different at the 5% threshold with a general average of 0.65g / ml. The study of the functional properties revealed that the percentage solubility and the water absorption capacity of wheat flours and compound flours are not significantly different at the 5% level; that the swelling power of all the flours is not significantly different at the 5% level with a general average of 0.057 g/g. This study also consisted in evaluating the fermentation activity of Saccharomyces cerevisiae during the fermentation at 30 °C of baking dough containing 0%, 5%, 10%, 15%, 20%, and 25% of flour of young shoots of palmyra palm. When the incorporation rate is equal to 5%, we observe an increase in the fermentation activity of Saccharomyces cerevisiae and a significant volume increase in the fermentation paste. However, when the flour content of young shoots is greater than 5%, a gradual decrease in the fermentation activity of the yeast is observed. The granulometric study revealed that the flour of young shoots of palmyra palm is the finest with a grain content of less than 63µm diameter higher.
Abnormal night melatonin level in a patient with well-controlled epilepsy without sleep disturbances – could it be associated with levetiracetam therapy: A case report
Authors: Orlina Georgieva Chaneva  , Zdravka Nikolaeva Vasileva
Published: June 2021

We present a case report of a 23-year old male with newly diagnosed epilepsy manifested with generalized tonic seizures. Levetiracetam (LEV) was started and the patient was seizure free. The patient demonstrated intermediate chronotype determined by the Morningness-Eveningness Questionnaire (MEQ). There was no epileptiform activity on electroencephalography (EEG) and polysomnography (PSG), sleep architecture disturbances (PSG) or daytime sleepiness (Epworth sleepiness score, Multiple sleep latency test) at the onset and after 3 months of LEV therapy. The melatonin serum levels after 3 months of LEV treatment were 22.00 pg/ml at 3 a.m. and 23.60 pg/ml at 8 a.m. - there was no normal night peak concentration. This abnormality may be associated with a later night peak melatonin concentration, the treatment with levetiracetam being a possible explanation. We consider the presented clinical case of special interest because of the combination of absence of normal night peak melatonin concentration, normal sleep parameters and non-extremely presented chronotype. We suggest that such patients could benefit from add-on therapy with melatonin.
Epidemiological, therapeutic, cytogenetic, and molecular profile of chronic myeloid leukemia at the national reference university hospital of N’Djamena from 2010-2020, Chad
Authors: Djimadoum Mbanga  , Bessimbaye Nadlaou  , Issakou Bakarnga-Via  , Josué Mbairané  , Choua Ouchemi  , Abdelsalam Tidjani  , Avocksouma Djona Atchenemou
Published: June 2021

The aim is to determine the epidemiological and cytogenetic profile (Philadelphia chromosome: Ph1) and the bcr-abl gene in patients with chronic myeloid leukemia (CML) and to assess the therapeutic response of patients to hydroxy-urea and Imatinib treatment. From January 1, 2010 to December 30, 2020, an observational study for diagnostic and analytical purposes was carried out in 54 cases of CML at the National Reference University Hospital (CHU-RN) of N’Djamena. All selected patients presented with splenomegaly on physical examination. Significant differences were observed between the proportion of housewives (31.48%) and civil servants (3.70%), emaciated patients (27.84%) and those with fever (3.70%) with the probabilities of 0.001 and 0.001 respectively. Hyperleukocytosis ranged from 100,000-149,000 GB / mm3 (42.30%) and the platelet count ranged from 20,000 / mm3 to 611,000 / mm3. Polymorphic and massive myeloma was 30-80% of cases, a medullary karyotype with 33.33% Ph1 + chromosome and 66.66% Ph1-, 33.33% bcr-abl transcript and 33.33% transcribed b3 a2 respectively. The treatment regimens were: Hydroxy-Urea (HU) + prednisolone (60%), and Imatinib + prednisolone (40%). Partial hematological remission was obtained in 40% of cases. CML is a condition that occurs at all ages and especially in men in our region. The continuation of this study at the national level will allow the public authorities to achieve national prevalence and to organize effective prevention and early management.
Revenue And Marketing Channel Of Oyster Mushroom In Probolinggo District
Authors: Lidyana Novita , Perwitasari Dyah Ayu , Rustianawati Mutimmah
Published: June 2021

This research is a quantitative research. Primary data is the result of filling out questionnaires by all respondents, namely all mushroom farmers in Probolinggo. And secondary data in the form of all mushroom farmer data in Probolinggo with a total population of 60 mushroom farmers in Probolinggo. The selection of oyster mushroom farmer respondents was carried out using the census method. The samples in this study were all farmers who cultivated oyster mushrooms in Probolinggo Regency. The results of this study indicate that oyster mushroom farmers in Probolinggo use logs. By using this tool, it can increase the income of mushroom farmers. So that the oyster mushroom in Probolinggo is suitable to be used as a business / developed field. The marketing channel pattern of oyster mushrooms in Probolinggo uses two patterns. Namely the first pattern, mushroom farmers sell mushrooms to resellers, resellers will resell to retailers and retailers will sell again to end consumers. For the second pattern, mushroom farmers sell resellers, and resellers will sell directly to the final consumer. From the above analysis it can be concluded that the second channel is more profitable for farmers in terms of income.
Elaboración de mapas axiológicos mediante el análisis de correspondencias simples en el discurso de la educadora Inés María Mendoza Rivera
Authors: Flores Muñoz Héctor Rubén
Published: June 2021

Nuestro problema de investigación se enmarca en la crisis de valores que enfrenta la sociedad contemporánea. El método analítico implementado es la técnica de análisis de contenido axiológico de naturaleza cuantitativo. Para sustentar los planteamientos se abordan los valores desde la perspectiva educativa y su importancia en la formación integral del ser humano. Los resultados obtenidos en la investigación coinciden con los ideales de la profesora Inés María Mendoza Rivera. Esta educadora contribuyó con la defensa de la enseñanza en el idioma español y el desarrollo de la educación en Puerto Rico a mediados del siglo XX. Los objetivos de esta investigación son: comprobar si los diversos niveles del modelo de Hall-Tonna tienen o no la misma incidencia en el discurso epistolar y narrativo de Inés María Mendoza y establecer mapas axiológicos a partir del cruce de los diferentes discursos considerados y el mayor o menor predominio de los diversos niveles axiológicos del modelo de Hall-Tonna.
La competencia comunicativa en estudiantes de los grados de Maestro: Una revisión sistemática
Authors: García-Martínez Inmaculada , Sierra-Arizmendiarrieta Beatriz , Quijano-López Rocío , Pérez-Ferra Miguel
Published: June 2021

Los avances tecnológicos han transformado las formas de comunicación e interacción en la sociedad y en el ámbito educativo. Estos cambios han incidido tanto en las instituciones escolares, como en los propios docentes, evidenciándose la necesidad de un replanteamiento de las funciones intrínsecas del profesorado, así como del tipo de formación que precisan para desempeñar su futuro ejercicio profesional eficazmente. A pesar de la volatilidad con la que el profesor actual debe lidiar, la competencia comunicativa sigue siendo una capacitación esencial, que debe trabajar y desarrollar para cumplir con su principal cometido, enseñar. La presente investigación tiene la finalidad de ofrecer una panorámica sobre cómo se trabaja la competencia comunicativa a nivel internacional. El diseño metodológico responde a una revisión sistemática, siguiendo las directrices PRISMA, en las bases de datos Web of Science y Scopus sobre el campo de la lingüística y la formación del profesorado. Los trabajos se estudiaron mediante un análisis de contenido cualitativo partiendo de una población de 434 artículos, siendo la muestra final, 19. Entre los hallazgos encontrados, se detecta la relevancia concedida a la consolidación de vías metodológicas orientadas a la transmisión del conocimiento lingüístico, así como la adquisición de la competencia comunicativa necesaria por parte de los estudiantes, en distintos niveles educativos. Asimismo, se observa una inclinación a señalar como importante la necesidad formativa en el futuro docente con respecto a la competencia comunicativa, marcándola como necesaria para su desempeño profesional.
Performance y fotografía: una aproximación a los primeros itinerarios en España
Authors: Tejo Veloso Carlos
Published: June 2021

Entendemos el suceder y el efímero tiempo compartido como elementos indisolubles de la performance, vindicando la presencia como uno de los pilares esenciales de esta práctica. Estas afirmaciones -que podrían resultar limitadoras- no desestiman la importancia de otros soportes como la fotografía o el video que, en ocasiones, interactúan con la performance a una estrecha distancia. Sensibles a estas aproximaciones, prestaremos especial atención a la colaboración que se establece entre performance y fotografía repasando conceptos como presencialidad, subjetividad, veracidad, documento o performatividad. Dada la amplitud del tema, hemos establecido una acotación temporal centrada en el contexto español de las fecundas décadas de 1960 y 1970. Estos años trajeron consigo la aparición de una simbiosis internacional entre el medio fotográfico y la performance; un despertar que impulsó significativos cambios de valor de la fotografía y -en el caso español- la conservación de una performance escasamente investigada.
Time that remains
Authors: Dobričić Igor
Published: June 2021

Encarte de Igor Dobričić
Performance y activismo. Contrapublicidad como estrategia por la justicia climática
Authors: Free Culture NL Fossil
Published: June 2021

Fossil Free Culture NL (FFC-NL) es un colectivo de artistas y activistas radicado en los Países Bajos, cuyo principal objetivo es romper los patrocinios y vínculos entre las corporaciones de combustibles fósiles y las instituciones culturales.

A través de sus propuestas artísticas, FFC-NL evidencia la disonancia cognitiva entre la misión de una institución cultural que promueve y preserva la cultura, y la aceptación de fondos de una corporación que es responsable de la destrucción de culturas y los sistemas naturales que sostienen la biodiversidad en este planeta, incluida la vida humana. Sin estos sistemas la cultura no sería posible.

Con sus acciones performáticas y estrategias de contrapublicidad, su trabajo ha conseguido importantes logros, como que el Museo Van Gogh (2018) y el Concertgebouw (2020) rompieran los lazos con Royal Dutch Shell, logrando una plaza de los Museos (Museumplein) de Ámsterdam, corazón cultural de los Países Bajos, libre de combustibles fósiles.
Efficiency of using a feed additive based on malt extract under stressful conditions
Authors: Tishina O.A. , Yarovan N.I.
Published: June 2021

The article presents the results of studying the degree of digestibility of a feed additive based on malt extract in animals. The question of the importance of a diet with a high content of nutrients is raised. The type and quality of feeding has a great influence on the body of animals. Only with full-fledged feeding and the creation of conditions for animals that meet their biological characteristics, it is possible to ensure intensive growth and long-term maintain high productivity due to hereditary data. The article also points out the importance of the use of plant antioxidants and adaptogens when the body is exposed to stress factors. An important non-specific trigger mechanism of the stress reaction is the activation of free radical oxidation, in particular lipid peroxidation, which leads to a violation of structural membranes and membrane enzymes. The article shows the possibility of using antioxidants in animals during the recovery period after the received stress factor. The concentration of total protein and the content of its fractions indicate the appropriate level of protein nutrition. Also, the study of these indicators characterizes the functional state of the liver, which is involved in the metabolism of substances, including protein. Total protein is an individual constant indicator that reflects the state of protein metabolism of the body, and, in this regard, is considered as the main link in the control of the digestibility of feed. Protein metabolism has a wide specificity and determines the state of carbohydrate and lipid metabolism. All metabolic transformations, anabolism and catabolism of organic substances are closely interrelated, coordinated and regulated by neurohormonal mechanisms, directing chemical processes in the right direction. The metabolism is not divided into the exchange of proteins, lipids and nucleic acids, but is a single metabolic process. The greatest positive effect was obtained when using malt extract in addition to the main diet in feeding. Also, good results were obtained when applying flaxseed oil and malt extract to the main diet.
RESEARCHING METHODS FOR PROCESSING TEXT INFORMATION AND REVIEWING THE STAGES OF AN ARTIFICIAL INTELLIGENCE MODEL CREATION AT PRODUCING CHATBOTS
Authors: Ivanova Anastasiya , Kuz'menko Aleksandr , Filippov Rodion , Filippova Lyudmila , Sazonova Anna , Leonov Yuriy
Published: June 2021

The task of producing a chatbot based on a neural network supposes machine processing of the text, which in turn involves using various methods and techniques for analyzing phrases and sentences. The article considers the most popular solutions and models for data analysis in the text format: methods of lemmatization, vectorization, as well as machine learning methods. Particular attention is paid to the text processing techniques, after their analyzing the best method was identified and tested.
PENGEMBANGAN MODUL PENANGANAN KESEHATAN MENTAL BERBASIS KOMUNITAS DI KABUPATEN MALANG
Authors: Nisa Walda Isna
Published: June 2021

Abstrak

Gangguan mental umumnya terjadi karena tekanan yang berasal dari faktor eksternal. Oleh karena itu, pengetahuan praktis mengenai gangguan jiwa selayaknya juga dipahami oleh masyarakat. Masyarakat diharapkan dapat berpartisipasi melalui metode pemberdayaan komunitas guna meningkatkan kemandirian dalam penanganan kesehatan mental, sehingga tidak ada lagi pasien gangguan jiwa yang di pasung dan kehilangan produktifitasnya. Penelitian ini bertujuan untuk memperoleh gambaran pelaksanaan pertolongan pertama kesehatan mental pada masyarakat Bantur yang dikemas dalam bentuk modul. Metode yang digunakan dalam penelitian ini adalah R&D dengan tahapan: 1)Identifikasi masalah, 2)Pengumpulan data, 3)Merancang produk, 4)Pengembangan produk, 5)Validasi dan evaluasi produk, 6)Diseminasi dan implementasi, 7)Pembuatan produk masal. Penelitian dilakukan di Kecamatan Bantur Kabupaten Malang dengan subyek penelitiannya adalah masyarakat yang memiliki keterlibatan dalam berbagai kasus Gangguan Mental. Berdasarkan hasil validitas uji kelompok sebanyak 81% dari 10 orang memilih bahwa modul sudah layak. Selain itu hasil dari validasi ahli modul ini termasuk dalam kriteria “Layak Digunakan”. Setelah dilakukan diseminasi dengan 30 peserta diketahui hasil pre-test adalah 60,3 dan post-test 64,37 dengan signifikansi 0,000 < 0,05 yang menunjukkan ada perbedaan yang signifikan terhadap pemahaman peserta sebelum dan sesudah sosialisasi modul. Maka dapat disimpulkan bahwa Modul Penanganan Kesehatan Mental Berbasis Komunitas ini layak dan efektif untuk digunakan.

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Interlingual Subtitles to Increase High School Students’ Ability in Understanding Explanation Texts
Authors: Pratama Ikke Dewi , Retnaningsih Woro , Prakoso Muhammad Romdhoni
Published: June 2021

This paper explores the use of interlingual subtitle as a media in teaching reading skill in one of private high schools in Surakarta. This research was initially conducted as the teachers found problems in teaching genres of texts, especially explanation text. Interlingual subtitle which is placed in videos is offered by the researchers as a solution and expected to help students in understanding the content of explanation text. This research uses classroom action research method with two cycles. The objectives of this research are to find out: 1) the implementation of interlingual subtitle in teaching explanation text, and 2) the impacts of interlingual subtitle on students’s achivements. The subjects of this research are 33 students of social science class and 33 students of natural science class. It is found out that interlingual subtitle can be used as a supplementary material in teaching explanation text. Interlingual subtitle has also contributed positively to the increasing scores of the students during the pre-test to the post-test.

 
DAMPAK APLIKASI FLY ASH DARI PEMBANGKIT LISTRIK DI PT. GREAT GIANT PINEAPPLE-LAMPUNG TERHADAP AKTIVITAS BIOLOGI TANAH DI LAHAN MARGINAL
Authors: Kurniawati Nurleni , Priyadi Priyadi
Published: June 2021

[EFFECT OF FLY ASH APPLICATION FROM POWER PLANT OF PT. GREAT GIANT PINEAPPLE ON SOIL BIOLOGYCAL ACTIVTY IN MARGINAL LAND]. Fly ash is a coal combustion waste containing nutrients that can be used to improve the soil fertility. The waste continues to increase but its handling is still limited because it is still classified as hazardous and toxic waste (B3). This study aims to determine the soil biological activity due to the application of fly ash and cow manure on marginal soils. The study was conducted using a completely randomized block design arranged factorial. The first factor is the dosage level of fly ash (F), namely 0 g/pot (0 ton/ha), 75 g/pot (50 ton/ha), 150 g/pot (100 ton/ha), and 225 g/pot (150 ton/ha) and the second factor is the dose of cow manure with three levels, namely 15 g/pot (10 ton/ha), 30 g/pot (20 ton/ha), and 45 g/pot (30 ton/ha). The observation parameters were (total population of fungi, bacteria, and soil respiration). The results showed that the addition of fly ash at various doses affected the soil biological activity by increasing the population of fungi, bacteria and soil respiration. The highest population of microorganisms was fungi, which was 17.8 x 107 Log CFU/g, bacteria 13.7 x 105 Log CFU/g, while the highest soil respiration was 54.53 mg CO2 at a dose of 100 ton/ha fly ash. In addition, the application of cow manure at a dose of 10, 20, 30 ton/ha  did not affect observed variables.
Medium, Small and Medium Enterprises and Digital Platforms
Authors: wijayap teddy
Published: June 2021

UAS PI Teddy Wijaya Pangestu
Tumor-targeted drug delivery systems for anticancer therapies can selectively provide an appropriate cytotoxic payload to cancer cells, reducing the side effects of chemo.
Authors: Dowaidar Moataz
Published: June 2021

Anticancer drugs aim to quickly divide and kill or destroy cells. Chemotherapy is effective, but it has the drawback of being unspecific. Other disadvantages of classical chemotherapy include inadequate drug therapy indices, evident toxicity, and increased risk of multidrug resistance (MDR) in long-term treatment. Furthermore, when these chemotherapy drugs are usually supplied, the dose may cause harm to many other critical organs in addition to healthy cells. Anticancer therapies are intensely interested in tumor-targeted drug delivery systems, since they not only boost the safety and efficacy of the drug, but also reduce the catastrophic side effects associated with chemotherapy. Such dynamically customized drug delivery devices can selectively provide an appropriate cytotoxic payload to cancer cells. They are beneficial in reducing some of the primary limitations of conventional medicines, such as bypassing biological barriers and overcoming drug resistance. Targeted medications limit harm to healthy cells while killing cancer cells. Because of their obvious benefits, customized medication delivery systems have taken their position in the drug delivery industry. Various ligands have grabbed researchers' attention in biological and therapeutic contexts and will continue to do so. FA-targeted delivery methods have already shown great effectiveness in preclinical models and considerable promise for future clinical applications. Because FR is overexpressed in a number of malignancies, FA must be employed as the preferred ligand to selectively target tumor cells and enjoy the benefits. Under in vitro, physiological and different storage circumstances, FA-(co)polymer and FA-drug conjugates were substantially more stable. To summarize, the major advantages of cancer targeting FA-nanoconjugates include selective internalization of nanoconjugates by cells (over) expressing FRs, simple conjugation chemistry, non-immunogenicity, and retention of nanoconjugate cargo in the endocytic vesicle after internalization rather than lysosomal processing as is the case with antibody.
Genome-editing is promising for producing therapeutically relevant animal models for possible therapies for rare human diseases
Authors: Dowaidar Moataz
Published: June 2021

The CRISPR/Cas9 genome-editing method shows tremendous promise in developing therapeutically relevant animal models to evaluate potential treatments for uncommon human illnesses. While damaging mutations are commonly fixed in laboratories in cultured cells and patient-derived iPSCs, CRISPR/Cas9 genome editing has emerged as a feasible technique to target somatic cells in rare monogenic and other genetically defined human illnesses. Recent advances in CRISPR/Cas9 technology have also enabled clinical gene therapy investigations. To get FDA clearance, several commercially accessible CRISPR/Cas9-based products have undergone several rounds of clinical development. The worldwide gene editing industry is anticipated to increase quickly to suit the therapeutic demands of several unique diseases that lack viable therapies. While this approach has hastened the development of breakthrough rare disease medicines, several key problems remain unsolved regarding the effectiveness, safety and off-target consequences of CRISPR/Cas9 genome editing in patients. Furthermore, anticipated clinical uses of genome editing pose ethical and regulatory challenges. Most gene therapy applications target somatic cells, such as blood and bone marrow cells, so genome alterations are not inherited and passed onto future generations. Due to the unclear long-term effects of germline gene therapy, possible treatments targeting germ cells are deemed dangerous.
Medium, Small and Medium Enterprises and Digital Platforms
Authors: Elier Inggrid
Published: June 2021

Central Bureau of Statistics of the Republic of Indonesia (Indonesian: Badan Pusat Statistik / BPS) states the Indonesian economy experienced deflation of 0.1% in July 2020. The food, beverage, and tobacco group experienced deflation of 0.79% and contributed to deflation of 0.19%. Foodstuffs that contributed to deflation included shallots, broiled chicken, rice, garlic, cayenne pepper and sugar. This deflation in food and beverages indicates a decline in demand for food.
Neurotrophin gene therapy may be able to treat individuals with noise-induced hearing loss or neural presbyacusis
Authors: Dowaidar Moataz
Published: June 2021

Neurotrophin (NT) cochlear gene therapy might perhaps give a single treatment that might greatly enhance neuronal survival, resulting in CI patients, provided the many challenges described above can be adequately addressed and safety concerns allayed by more animal model investigations. This is particularly crucial for juvenile CI patients, who have to rely on electrical hearing for the remainder of their lives, and whose outcomes are quite different. In addition, NT gene therapy may have the potential to treat patients with noise-induced hearing loss or neural presbyacusis (e.g., age-related cochlear synaptopathy), where primary neuronal loss is a key cause of hearing loss. Animal research into noise-induced hearing loss has shown that even exposures that generate only reversible threshold alterations and no hair cell loss can lead to permanent loss of SGN synapses on hair cells, resulting in functional impairments and ultimately SGN degeneration. Cochlear synapses frequently precede both hair cell loss and threshold increases in human ears, according to current studies. Cochlear synaptopathy is characterized by ears with intact hair cell populations and normal audiograms as "hidden" hearing loss. Many frequent perceptual abnormalities, including speech-in-noise difficulties, tinnitus, and hyperacusis, are likely produced by suppressing affected neurons, which radically alters information processing. Thus, in the future, NT gene therapy may be successful in inducing SGN peripheral axon resprouting and synaptic regeneration into residual (or even regenerated) hair cell populations. We have demonstrated compelling evidence that, in this investigation, BDNF gene therapy can boost SGN survival and enhance peripheral axon maintenance or rerouting. NT-3 has been found in adult animals exposed to acoustic damage to induce synaptic regeneration of these fibers, reconnecting them to hair cells and their ribbon synapses, and restoring hearing function. Combining BDNF and NT-3 gene therapy may be the most effective way to maintain/restore a more normal cochlear neuronal substrate.
Analisis Penggunaan Model Inkuiri Untuk Mengetahui Kemampuan Representasi Verbal Dan Matematis Dalam Pembelajaran Fisika Di SMA
Authors: mubarok ilham
Published: June 2021

Tujuan penelitian ini untuk mengetahui penggunaan pembelajaran fisika model inkuiri pada siswa SMA pada kemampuan representasi verbal dan matematis. Pada pembelajaran fisika perlu adanya pengetahuan teori dasar dan aplikasinya, jadi tidak hanya sekedar mengetahui rumus-rumus matematika dan mengerjakan soal matematika. Penulisan ini didesain sebagai penelitian studi literature dengan mengkaji beberapa sumber untuk dikaji dan dibuat kesimpulan. Hasil penulisan mendapatkan bahwa kemampuan representasi verbal siswa yang menggunakan model inkuiri inkuiri termasuk dalam kategori tinggi, sedangkan kemampuan representasi verbal siswa yang tidak menggunakan model inkuri termasuk dalam kategori sedang. Kemampuan representasi matematis siswa yang menggunakan model inkuiri dan yang tidak menggunakan model inkuiri termasuk dalam kategori tinggi. Dengan demikian, perlu adanya kesiapan siswa dalam menerima berbagai metode pembelajaran.
MSMEs and Digital Platforms
Authors: Suharsono Andrea Anne
Published: June 2021

There should be mutual reinforcement between MSMEs and large businesses in the context of equitable distribution and realizing the greatest possible prosperity for the entire community. The government is obliged to direct, guide, protect and foster the business climate.
EFEK RUMAH KACA
Authors: Astutin2505 Liya
Published: June 2021

Sinar matahari yang tidak terserap permukaan bumi akan dipantulkan kembali dari permukaan bumi ke angkasa. Setelah dipantulkan kembali berubah menjadi gelombang panjang yang berupa energy panas. Namun sebagian dari energi panas tersebut tidak dapat menembus kembali atau olos ke luar angkasa, karena lapisan gas-gas atmosfer sudah terganggu komposisinya. Akibatnya energy panas yang seharusnya lepas ke angkasa (stratosfer) menjadi terpancar kembali ke permukaan bumi (traposfer) atau adanya energi panas tambahan kembali lagi ke bumi dalam kurun waktu yang cukup lama, sehingga lebih dari kondisi normal, inilah efek rumah berlebihan karena komposisi lapisa gas rumah kaca atmosfer terganggu, akibatnya memicu naiknya suhu rata-rata dipermukaan bumi maka terjadilah pemanasan global.
CRISPR/Cas9 has introduced new gene therapy possibilities for muscular dystrophies
Authors: Dowaidar Moataz
Published: June 2021

Advancements in using CRISPR/Cas9 have introduced a host of new therapy possibilities for muscular dystrophies (MDs). There is a definite feeling of hope in the industry, but other barriers lay ahead, and they will define the future of MD gene editing. The ambiguity surrounding AAV transduction of satellite cells in vivo must be explained so that, if required, effort may be focused on optimizing vector targeting. Although the satellite cell correction needs are evident, it must be determined experimentally if high muscle turnover has a deleterious effect on CRISPR approaches. Another issue with muscular HDR is its low editing efficiency. Even outside the MD, exogenous, effective DNA integration would open up a slew of new possibilities.Either conventional HDR must be upgraded, or alternative techniques must be developed. The fact that both myotubes and latent satellite cells are post-mitotic means the latter are the most effective. Homology-independent targeted integration (HITI), homology-mediated end joining (HMEJ) and prime editing are three novel potentials. Duplication removal is another technique to restore full-length proteins. Duplications are the second most frequent DMD mutation, and a single sgRNA technique was used to restore dystrophin. To date, CRISPR/Cas9-mediated duplication removal has only been evaluated in DMD patient cells and must be tested in vivo. Because of their demonstrated track record in in vivo research and clinical trials, AAVs are expected to be employed in early generations of MD CRISPR therapy. Currently, AAVs may be the biggest choice, but future drugs will almost probably require a different delivery approach. It may take the shape of nanoparticles, which may carry a large range of transiently expressed payloads, while being very variable. If satellite cells can not be repaired, their capacity to escape immune reactions is crucial. To decrease the effects of muscle turnover, re-administration of nanoparticles may be utilized to treat MD throughout one's life. However, effective nanoparticle dosing for CRISPR in vivo editing has yet to be established in the muscle. Because this was not an AAV problem, the focus should be on new compositions of nanoparticles rather than improving the CRISPR/Cas9 system. The lack of published data suggests that nanoparticles' systemic muscle transport remains a considerable challenge. Due to muscle volume in the human body and the need to target muscles within the thoracic cavity, local intramuscular injections are not practical. Future research will focus primarily on developing an effective, muscle-specific nanoparticle that can be administered through circulation. The challenges ahead are tremendous, but with the appropriate focus and resources, answers will emerge, bringing therapeutic genome editing closer to the clinic than ever. While this research focused on DMD, the mentioned principles and methodology may and will undoubtedly be extended to several other MDs.
Affective Regulation Through Touch: Homeostatic and Allostatic Mechanisms
Authors: Fotopoulou Aikaterini , Von Mohr Mariana , Krahé Charlotte
Published: June 2021

We focus on social touch as a paradigmatic case of a unifying perspective on the embodied, cognitive and metacognitive processes involved in social, affective regulation. Social touch appears to have three interrelated but distinct functions in affective regulation. First, it regulates affects by fulfilling embodied expectations about social proximity and attachment, mostly likely by convergent hedonic, dopaminergic and analgesic, opioidergic pathways. Second, caregiving touch such as feeding or warming an infant regulates affect by socially enacting homeostatic control and co-regulation of physiological states, most likely by corresponding ‘calming’ autonomic and endocrine pathways. Third, affective touch such as gentle stroking, kissing or tickling regulates affect by allostatic regulation of the salience and epistemic gain of particular experiences in given contexts and timescales, possibly regulated by oxytocin release and related ‘salience’ neuromodulators and circuits.
Inequalities in population health loss by multiple deprivation: COVID-19 and pre-pandemic all-cause disability-adjusted life years (DALYs) in Scotland
Authors: Wyper Grant Mark Andrew , Fletcher Eilidh , Grant Ian , Harding Oliver , de Haro Moro Maria Teresa , Stockton Diane L , McCartney Gerard
Published: June 2021

Background: COVID-19 has caused almost unprecedented change across health, education, the economy and social interaction. It is widely understood that the existing mechanisms which shape health inequalities have resulted in COVID-19 outcomes following this same, familiar, pattern. Our aim was to estimate inequalities in the population health impact of COVID-19 in Scotland, measured by disability-adjusted life years (DALYs) in 2020. These were scaled against pre-pandemic inequalities in DALYs combined across all causes, derived from the Scottish Burden of Disease (SBoD) study.Methods: National deaths and daily case data were input into the European Burden of Disease Network consensus model to estimate DALYs. Total Years of Life Lost (YLL) were estimated for each area-based deprivation quintile of the Scottish population. Years Lived with Disability were proportionately distributed to deprivation quintiles, based on YLL estimates. Inequalities were measured by: the range, Relative Index of Inequality (RII), Slope Index of Inequality (SII), and attributable DALYs were estimated by using the least deprived quintile as a reference. Overall, and inequalities in, COVID-19 DALYs were scaled against pre-pandemic estimates of inequalities across all causes from the SBoD study.Results: Marked inequalities were observed across several measures. The SII was 2,048–2,289 COVID-19 DALYs per 100,000 population. The RII was 1.16, meaning that the rate in the most deprived areas was around 58% higher than the mean population rate, with 40% of COVID-19 DALYs attributed to differences in area-based deprivation. Overall DALYs due to COVID-19 ranged from 7–20% of the annual pre-pandemic impact of inequalities in health loss combined across all causes.Conclusion: The substantial population health impact of COVID-19 in Scotland was not shared equally across areas experiencing different levels of deprivation. The extent of inequality due to COVID-19 was similar to averting all annual DALYs due to diabetes. In the wider context of population health loss, overall ill-health and mortality due to COVID-19 was, at most, a fifth of the annual population health loss due to inequalities in multiple deprivation. Implementing effective policy interventions to reduce health inequalities must be at the forefront of plans to recover and improve population health.
PROBLEMATIKA KEUANGAN PADA PERUSAHAAN MANUFAKTUR DI INDONESIA
Authors: Nuraini Ani
Published: June 2021

Dalam buku ini membahas tentang pengaruh informasi non finansial yang terdiri dari variabel Corporate Governance, R&D, Informasi Pasar dan Faktor Makro yang di mediasi oleh Informasi Finansial berupa Financial Performance yang terdiri dari CR, TATO, DAR dan ROE, dengan menggunakan pengaruh tidak langsung dan pengaruh langsung terhadap Probabilitas Default. Dalam hasil kajian menemukan bahwa Financial Performance yang berpengaruh signifikan Corporate Governance, R&D, Informasi Pasar, sedangkan Faktor Makro yang signifikan adalah interest, akan tetapi R&D memberikan pengaruh menurunkan Financial Performance. Tahap kedua regresi logistik dengan variabel dependen Probabilitas Default yang signifikan Financial Performance, Corporate Governance dan Informasi Pasar, sedangkan R&D, faktor makro dan variabel kontrol tidak signifikan secara langsung, akan tetapi dengan mediasi Financial Performance variabel R&D dan variabel makro interest signifikan dalam mempengaruhi Probabilitas Default.
Nurturing Professionalism in current Health Professions Education
Authors: Rimal Jyotsna
Published: June 2021

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Enhancing operational efficiency of Vietnamese textile and garment enterprises in the context of the EVFTA
Authors:   Banking Academy, The State Bank of Vietnam, Tran Thi Thu Huong , Pham Tien Manh ,   Banking Academy, The State Bank of Vietnam
Published: June 2021

The textile and garment industry is one of the main export sectors of Vietnam, contributing significantly to the economic growth of the country. From the beginning, the textile and garment industry is developing day by day and there are changes to adapt to new economic conditions. The EVFTA is considered to be a boost for Vietnamese textile and garment enterprises with many opportunities and challenges. In the new context, these firms need to have more positive changes to take advantage of opportunities that the Agreement brings to improve operational efficiency. This article analyses the opportunities and challenges that the EVFTA brings to the Vietnamese textile and garment enterprises. In addition, empirical research is applied to study the factors affecting the performance of enterprises in this sector, to find out solutions to them improving operational efficiency in the context of the new agreement taking effect.