bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Pembelajaran Life Skill Education dalam Upaya Penguatan Pendidikan Karakter di Kabupaten Bone
Authors: Arifuddin Arifuddin , Suhra Sarifa , Nursaba Sarifa , Halijah Sarifa
Published: July 2023

This paper aims to reveal the suitability of Life Skills Education learning with the 2013 curriculum which is able to strengthen the character education of students in schools designated by the local government as Unicef piloting schools in Bone Regency. This research is located in SMP Negeri 2 Ajangale so it includes field research using a qualitative approach. The research instrument used an interview guide and google form. The results showed that; The formulation of Life Skills Education Learning Implementation that is Relevant to the 2013 Curriculum is based on six core curriculum components, namely, curriculum objectives, Program/Material Content and Structure, Learning media, methods, and evaluation.These characters include; the ability to self-regulate, creative, critical thinking, making decisions, negotiating, cooperating, solving problems, participating, able to manage stress and emotions, resilient, able to survive, empathize with communication, and appreciate differences.
Efektivitas Penggunaan Metode A Ba Ta Tsa dalam Pembelajaran Al-Qur’an di LTQA Ibnu Mas’ud Beurawe Banda Aceh
Authors: Hikmah Nadyatul , Isri Saifullah , Zulkhairi Teuku
Published: July 2023

The learning method is a way that is taken by educators in delivering subject matter in order to achieve effective learning objectives. Among the methods used to eradicate illiteracy in the Qur'an is the A Ba Ta Tsa method at the Ibn Mas'ud Children's Tahfizh Qur'an Institute (LTQA) Beurawe Village Banda Aceh, but in practice there are still educators who have not applied the A method. Ba Ta Tsa properly and correctly. This study aims to determine the process of implementing Al-Qur'an learning using the A Ba Ta Tsa method, to determine the competence and professionalism of teachers in using the A Ba Ta Tsa method and to find solutions to the problems that occur in the process of implementing ak-Qur'an learning. based on the A ba Ta Tsa method at LTQA Ibnu Mas'ud, Beurawe Village, Banda Aceh. The method used in this research is classroom action research. The subjects in this study were educators and students. Data collection techniques in this study using observation and tests. The results of this study indicate that the process of implementing the learning of the Qur'an using the A Ba Ta Tsa method has been effective with the average achievement of each cycle is 89%, the competence and professionalism of the teacher in using the A Ba Ta Tsa method is very good and every problems always find solutions to solve them. So that the use of the A Ba Ta Tsa method in Ibn Mas'ud's LTQA has been implemented well.
Urgensi Akhlak Bagi Guru dalam Menjalani Kehidupan di Era Society 5.0
Authors: Ichsan Muhammad
Published: July 2023

In the current era of Society 5.0, talking about the urgency of morality, especially for teachers, is an interesting matter, where with the current dynamics, many teachers do not understand the urgency of morality, so they do not show noble character, that is, they cannot be an example for students or society. Therefore, the importance of these morals needs to be known and learned and practiced in everyday life so that they can continue to improve themselves and their people in a better direction. Morals are conditions or characteristics that are imprinted and seep into the soul, so that the perpetrator of the deed does something spontaneously and easily without making it up. Morals according to the understanding of Islam is one of the results of faith and worship, because human faith and worship are not perfect unless noble morals emerge from them. Therefore, morality in Islam is rooted in faith and piety and has a direct goal, a close one, namely self-esteem and a distant goal, namely the pleasure of Allah SWT. Among the goals of education is to form good morals in children and this is only possible if the teacher has good morals too. This means that morals are in accordance with Islamic teachings, as exemplified by the main educator, namely the Apostle Allah Muhammad Saw. As for the moral urgency for educators (teachers) in life in the 5.0 era, they include: 1) Increasing the degree of piety, 2) Encouraging goodness, 3) Perfection of faith, 4) Virtue in the afterlife, and 5) Getting along with neighbors.
Konseling Trait and Factor untuk Meningkatkan Self Confidence Siswa
Authors: Muslima Muslima
Published: July 2023

The purpose of this study was to find out the application of Trait and Factor counseling in increasing the Self-Confidence of students at MTsN 4 Pidie and SMP Negeri 4 Sakti, by helping students to increase their self-confidence in the learning process at school and outside of school. Knowing the condition of students' self-confidence is still at a low level, counseling is given to increase self-confidence. The research method used was pre-experimental designs with one group pretest-posttest design. The results of the study showed that students with low self-confidence, lacked focus during PBM, students were passive and indifferent during the teaching and learning process, were not enthusiastic about participating in school activities, there were still many students who cheated when there were assignments. But problems can be overcome by providing Trait and Factor counseling, students are given treatment through Trait and Factor counseling with self-confidence material. The results obtained were an increase in scores from the initial pretest and posttest results at the end.
STRATEGI INOVATIF GURU PENDIDIKAN AGAMA ISLAM DI ERA SOCIETY 5.0
Authors: Anida Anida
Published: July 2023

The era of society is a refinement of the previous industrial era 4.0. The era of society shows a minimal human role which all leads to the use of machines or ICT in various fields. This era has an impact on all lines of life including the education sector. For this reason, Islamic religious education needs to improve and innovate learning strategies to be better and in accordance with the times. This research is library research by analyzing related studies to produce a conclusion regarding the innovative strategy of Islamic education in the era of society 5.0. through this study shows that one of the things that needs to be done in Islamic education is to change the paradigm of thinking about the concept of Islamic learning and opening oneself to new things as a support for accelerating the understanding of religious objects in students. This includes getting used to the learning process using the e-learning system with an interesting approach and adapting to the environment.
K
Authors: Fahmi Angga , Mesiono Mesiono , Salminawati Salminawati
Published: July 2023

Strengthening character education through honestness and responsibility habitation in pai learning at SD MUHAMADIYAH 30 MEDAN. This study aims to determine (1) how to plan a program to strengthen character education through the habit of honesty and responsibility in PAI learning at SD Muhamadiyah 30 Medan. (2) How is the strategy for implementing strengthening character education through the habit of honesty and responsibility in PAI learning at SD Muhamadiyah 30 Medan. (3) How do teachers assess the success of strengthening character education through the habit of honesty and responsibility in PAI learning at SD Muhamadiyah 30 Medan. (4) What are the supporting and inhibiting factors in strengthening character education through the habit of honesty and responsibility in PAI learning at SD Muhamadiyah 30 Medan. The research material is Islamic religious education teacher and the sample is class students V SD Muhamadiyah 30 Medan. This type of research is qualitative, with descriptive analysis. The results showed that strengthening character education through the habit of honesty and responsibility in PAI learning at SD Muhamadiyah 30 Medan. The conclusions show (1) planning can be done by planning activities to be carried out in writing and focusing on what characters are instilled in students to make it easier for teachers to provide character strengthening to students. (2) The teacher as a character model cooperates with parents and the environment as well as consistency in giving character reinforcement to children, then the teacher must be active in managing learning. (3) Paying attention to taking an in-depth approach and testing whether the child's attitude has changed and has what character it has not. (4) Parents, teachers and the surrounding environment and facilities are supporting factors as well as obstacles in strengthening student character education.
TASAUF SEBUAH PENDEKATAN PENDIDIKAN AKHLAQUL KARIMAH DALAM KONTEKS PEMIKIRAN QUR’ANI
Authors: Miskahuddin Miskahuddin
Published: July 2023

Talking about Sufism, of course, cannot be separated from the efforts of a servant of Allah in his efforts to purify his personality with good deeds to produce good morals through worship to draw him closer to Allah S.W.T. based on the teachings of the Qur'an al-Karim as a guideline of his life in this world. Al-Qur'an as a way of life for all mankind is able to teach eternal goodness and as the main model that is truly perfect for moral education in order to shape the good morals of the Muslim human person, especially for those who believe in him by always studying and practicing all the contents of his teachings alone. Sincere eyes hope for the pleasure of Allah so that with Allah's permission, humans who are haqqul sure to practice it truly will certainly be able to lead them to glory and happiness both physically and mentally in this world and the safety of happiness in the hereafter. In relation to moral education for humans in the Sufism approach, it can actually be said that their efforts are trying to purify themselves which will not break away from the guidance and guidance of the Qur'an as the main basis for improving human morality so that they become obedient and ethical servants of God. karimah. Sufism as a science can be a movement of Islamic teachings that teach knowledge about how to purify the soul and clarify morals in order to build the body and mind of humans so that they can obtain true happiness in the world and also eternal happiness in the hereafter.
Model Kepemimpinan Digital Kepala Sekolah di Era Teknologi
Authors: Zubaidah Zubaidah , Putra Rahmad Syah
Published: July 2023

Currently, transformation has occurred so quickly, the Industrial Revolution Era was one of the eras of very rapid technological development. With the rapid development of technology, various knowledge, new skills, and new leadership have been born in realizing the competitiveness of an educational institution. This article aims to describe the leadership of school principals in the technological era. The writing of this article uses a qualitative descriptive approach (library research), by conducting a careful review of some material and leadership theory. The results of the study show that: 1) a leader or leaders in the technological era in order to bring a team to a better realm, must master 10 (ten) skill models namely complex problem solving, critical thinking, creativity, management ability, coordination, emotional intelligence , making policies/decisions, service orientation, negotiation, and cognitive flexibility; 2) There are digital leadership characteristics that exist in a school principal in the Technology Age, including: responsibility and innovation in order to direct the organization to transform towards digital; 3) The implementation of digital leadership in educational institutions, of course, must be carried out by a Principal with several stages, namely: The emerging, implementing, instilling and transforming stages, and 4C, namely; critical in thinking and able to generate solutions, communication, collaborative, as well as creative and innovative.
Peningkatan Hasil Belajar Siswa Kelas IX SMP Negeri 2 Jeunieb melalui Pemanfaatan Media Audio Visual pada Materi Qurban dan Aqiqah
Authors: Nasriati Nasriati , Nurbayani Nurbayani
Published: July 2023

The low learning outcomes of class IX students of SMP Negeri 2 Jeunieb are due to the lack of direct student involvement in the learning process. To overcome this problem, conducted classroom action research (CAR) through the use of Audio Visual Media. The purpose of this study was to determine the increase in student activity and learning outcomes by using Audio Visual Media for class IX at SMP Negeri 2 Jeunieb. The research subjects consisted of 30 students. The source of the research data was obtained from qualitative data in the form of data from observations of teacher and student activities as well as quantitative data in the form of test data on student learning outcomes. The results of the first cycle of research on the ability to understand qurban and aqiqah material after using audio-visual media reached a class average of 54% in the less good category. The implementation of cycle II was able to improve the learning process of cycle I. This was shown in the class average test scores of 81.73%. This was also shown in students being more active in learning, they held discussions to find good learning outcomes, were able to work in groups and able to understand qurban and aqiqah material well. Teacher activities in cycle II also show that teachers are more prepared, able to motivate students and able to explain material well and carry out their main role as facilitators and student assistants in conducting discussions to find a learning outcome. Based on these research results, learning using Audio Visual Media can improve the learning outcomes of class IX students of SMP Negeri 2 Jeunieb.
Fenomenologis Moderasi Beragama pada Madrasah di Aceh
Authors: Muhammad Imran
Published: July 2023

Today, in understanding, the millennial generation has appeared to deviate from the concept of moderation, as evidenced by the emergence of terror from millennials. Today's millennials are trapped in religious ideology which has the potential to damage the peace and harmony of the nation and state. The adherents of this ideology are easy to recognize, among the criteria that appear and can be seen immediately are in terms of attitude, such as feeling themselves the holiest, most righteous, apart from those who are heretics, heretics, and even disbelievers. This study tries to describe the phenomena that occur and the efforts of madrasas in Aceh in fostering students not to be trapped in religious phenomena that undermine the peace of the nation and state. The results of the study show that these radical or extremist actors indoctrinate millennials with an understanding that is contrary to the government's attitude towards the diversity of religious communities or stereotypes towards Religious Moderation. besides that through the use of information technology such as social media by creating content that leads to rejection of government policies, especially regarding religious moderation. The efforts of madrasas in Aceh in fostering students are through habituation of spiritual attitudes and character development in extracurricular activities.
The Tradition of the Angkola People on Slaughtering Buffaloes in the Death Ceremony
Authors: Rasyid Arbanur , Lubis Rayendriani Fahmei , Lubis Maulana Arafat , Azizan Nashran
Published: July 2023

This study aims to determine the background, process, and purpose of the Angkola people in slaughtering buffalo in a death ceremony. This study uses a descriptive analysis approach to describe the results of the research findings. In addition, the researcher used observation, interview, and document analysis techniques in collecting research data. The results indicate several reasons behind the slaughtering buffalo in the death ceremony. First, this tradition aims to preserve the Angkola cultural customs that have existed since Islam entered Indonesia. Besides, it also drives to keep the titles held by parents from being lost. Socially, this ritual is planned to feed the public where there are generally many people who come to see the procession. Lastly, Mora Kahanggi and Anak Boru played a significant role in supporting the funding for this ritual.
Evolución clínica en neuromielitis óptica comparando el manejo con azatioprina o rituximab
Authors: Sánchez Botero Paulina , Gómez Laverde Tomás , Vallejo Tamayo Sara , Tarquino Castro Isabella , Ramírez Villada Natalia , Restrepo Carlos A. , Zuluaga María I.
Published: July 2023

INTRODUCCIÓN:
El espectro de trastornos de neuromielitis óptica (NMOSD) es un grupo de enfermedades desmielinizantes, inflamatorias y autoinmunes, caracterizadas por episodios recurrentes de neuritis óptica y mielitis transversa longitudinal extensa, entre otras manifestaciones clínicas. Su tratamiento crónico se basa en el uso de terapias inmunosupresoras como azatioprina (AZA), micofenolato mofetilo (MFM) o rituximab (RTX). El objetivo del presente estudio es realizar un análisis comparativo de la respuesta al tratamiento con AZA o RTX.

MATERIALES Y MÉTODOS:
Se realizó un estudio observacional, analítico, retrospectivo, en el cual se incluyeron inicialmente 69 pacientes con diagnóstico confirmado de NMOSD. Tras aplicar los criterios de inclusión y exclusión 59 pacientes fueron incluidos en el análisis final.

RESULTADOS:
En el grupo de RTX se evidenció una mejoría importante en el estado funcional en comparación con el grupo de AZA, en el que se vio un empeoramiento de este al año de seguimiento. El perfil de seguridad fue similar entre ambos grupos, con una adherencia significativamente superior en el grupo de RTX.

DISCUSIÓN:
Los hallazgos del presente estudio respecto a las ventajas del uso de RTX sobre AZA se encuentran en concordancia con resultados de estudios previos reportados en la literatura.

CONCLUSIONES:
Los resultados respaldan el uso de RTX sobre AZA como terapia de mantenimiento para pacientes con NMOSD, al estar asociado principalmente con una mejoría notable en la funcionalidad de los pacientes, al igual que una mayor adherencia al tratamiento.
Desenlace funcional asociado al ataque cerebrovascular menor en una población colombiana: un estudio de cohorte
Authors: Silva-Sieger Federico Arturo , Álvarez-Pabón Yelitza , López-Romero Luis Alberto
Published: July 2023

INTRODUCCIÓN.
El ACV menor hace referencia a un evento isquémico que cursa con síntomas leves. Se ha señalado que estos pacientes pueden presentar un desenlace clínico desfavorable.

OBJETIVO:
Evaluar el desenlace funcional a 90 días de pacientes con ACV isquémico menor, atendidos en dos hospitales de Bucaramanga, Colombia, entre los años 2015 y 2017.

MÉTODOS.
Estudio de cohorte en pacientes con ACV isquémico agudo y un puntaje NIHSS ? 5 puntos. Un desenlace clínico desfavorable a 90 días de seguimiento fue medido como un puntaje Rankin-m ? 3 puntos. Se realizó un análisis bivariado a través de modelos de regresión binomial simple y ajustado por edad y sexo. Un valor p <0,05 fue considerado estadísticamente significativo.

RESULTADOS.
Se incluyeron 90 pacientes (edad de 66,6± 13,5 años, 54,4% (n=49) de sexo masculino). El 36,5% (n=23) de los pacientes presentó un puntaje Rankin-m de 3 a 6 puntos. El antecedente de diabetes mellitus (RR: 2,50 IC 95%:1,33-4,70) y un Rankin-m previo de 2 (RR 2,12 IC 95%:1,39-3,24) fueron variables independientemente asociadas a discapacidad significativa.

CONCLUSIÓN.
Un estado funcional previamente comprometido, sumado a la disfunción endotelial que genera la diabetes mellitus, contribuye a un desenlace desfavorable en los pacientes con ACV menor.
Evaluación de síntomas neuropsiquiátricos para la detección temprana de trastorno neurocognoscitivo
Authors: Botero-Rodríguez Felipe , López Figueroa Catalina , Moreno-Contreras Juanita
Published: July 2023

INTRODUCCIÓN:
El diagnóstico oportuno del trastorno neurocognitivo es de los principales retos en la atención de los trastornos neurocognitivos. Por esto, se han generado estrategias para la detección preclínica de la enfermedad, entre ellas las destinadas a evaluar síntomas neuropsiquiátricos (NPS) como la escala Mild Behavior Impairment - Checklist (MBI-C).

MÉTODOS:
Inicialmente se realizó una búsqueda en BVSalud, Medline y PsycNet, luego se realizó una búsqueda en bola de nieve. Se incluyeron términos referentes a deterioro comportamental leve (abarcando los NPS en etapas tempranas), deterioro cognitivo leve y términos específicos del MBI-C.

RESULTADOS:
La presencia de NPS se asocia con un aumento en la incidencia anual de demencia. Al evaluarlos con MBI-C, su puntuación se correlaciona con biomarcadores como una mayor atrofia cortical, la presencia de la proteína ?-amiloide, así como disminución en funciones ejecutivas como la capacidad de enfocar la atención y la memoria de trabajo.

DISCUSIÓN:
Los hallazgos en la literatura sugieren la utilidad de MBI-C como marcador de neurodegeneración en estadios previos a la demencia, esto mediante la evaluación de su capacidad predictiva de forma independiente y al compararla con otros biomarcadores.

CONCLUSIONES:
MBI-C supone ser un instrumento de fácil aplicabilidad e interpretación, sostenible e incluyente. Sin embargo, quedan vacíos sobre la pertinencia de esta escala, por lo que surge la necesidad de investigar este tema.
THEORETICAL APPROACHES TO THE STUDY OF SOCIAL AND LABOR RELATIONS
Authors:   Central Russian Institute of Management, Branch of RANEPA, KAIRA Yu.V. , SAPRYKIN S.S. ,   LLC “FLUID-LINE”
Published: July 2023

This work is devoted to the consideration of theoretical approaches to the study of social and labor relations. The purpose is to consider theoretical approaches to the study of social and labor relations in their historical development both abroad and in domestic science and present them in relation to the conditions of the transforming social and professional sphere of the modern Russian society. The achievements of Soviet scientific thought in terms of organization, work culture, influence of external and internal factors on labor relations, as well as study of the workers’ reaction and influence of interpersonal relations in the team are highlighted. The article presents the prerequisites and historical continuity of theoretical scientific thought in the analysis of the nature of social and labor relations and their correlation with the observed social reality. The role of social and labor functions and actual typologies of relations in modern conditions are considered separately. Contradictions in labor relations are revealed against the background of modern problems of regional labor markets. As a result, it is summarized that social and labor relations have changed, developed and transformed under the influence of socio-historical realities, but labor values remained and still remain the regulator of the employee's labor behavior, and their study will improve both the efficiency of social and labor relations and all labor activity.
IMPROVING THE STATE POLICY IN THE SPHERE OF THE AGRO-INDUSTRIAL COMPLEX OF MODERN RUSSIA: DOCTRINE AND INSTITUTIONS
Authors:   ANO ", ALIMENKO I.A. ,   Agency for Regional Socio-Economic Projects",   LLC “Logrus-Agro”
Published: July 2023

The purpose of the work is to conduct a research analysis of the effectiveness the state policy of the agricultural sector after the adoption of the "Food Security Doctrine", while focusing on the quality of doctrinal documents and on the effectiveness of the development institutions that affect the agro-industrial complex. The article explores the essence of the priorities of the state agro-industrial policy taking into account the Food Security Doctrine adopted in 2010. The importance of development institutions in improving this policy, which has a positive effect on the saturation of the domestic food market, is highlighted. The authors, in the framework of the analysis of the available empirical information on the problems of the agro-industrial complex, come to the conclusion that the state policy in relation to this industry had three important dimensions. First, it is the solution of acute food problems that threatened socio-political stability and political order. Secondly, it is the relief of the negative effects of the backwardness of the agricultural sector, which requires modernization, which has become one of the drivers of economic growth since the 2010s. Thirdly, it is a radical reduction in the country's dependence on imported food. The research results are based on the following. First, the state agro-industrial policy of the Russian Federation in the 2000s led to the saturation of the Russian market with domestic agricultural products, and the country's dependence on imports of this type of goods was reduced. Secondly, the availability of doctrinal and strategic documents of this type of sectoral policy led to the achievement of the planned indicators of the "Food Security Doctrine" for grain, meat (pork and chicken), sunflower oil by the beginning of 2020. Thirdly, the improvement of the state policy in the sphere of the agro-industrial complex is possible only in the conditions of activation of the old, stimulation of new development institutions. At the same time, the functioning of these institutions should be based on effective interaction between the state, business, the scientific and expert community.
Políticas públicas sobre el cambio climático
Authors: Cueva Quezada Nilton Isaías , Morales Mijahuanca María Elizabeth , Gonzales Dongo Américo Jesús , Ludeña González Gerardo Francisco , Medina Sotelo Cristian Gumercindo
Published: July 2023

Introducción. El cambio climático representa para el mundo una de las amenazas más latentes de los últimos tiempos, cuyas consecuencias para la humanidad representan el principal reto de los gobiernos y sus políticas públicas. Objetivo. Conocer la grave problemática que viene causando el cambio climático al planeta, así como las políticas públicas implementadas. Materiales y métodos. La metodología empleada fue la descripción narrativa mediante la revisión y análisis de la información producto de la búsqueda de información en las bases especializadas Scopus, Web Of Science, Scielo y Redalyc. Resultados. Se demuestra que con las normas actuales no es viable combatir la excesiva generación de gases de efecto invernadero Conclusiones. El calentamiento global es irreversible y el principal causante de la desglaciación, por ende, de la pérdida gradual de los glaciares lo que generará la disminución del agua y el desabastecimiento de agua potable.
From mass to structure: modified van Krevelen diagram and adjusted indexes for high-resolution mass data of organic matter
Authors: Xiaoqiu Yang , Chen Hechao , Wu Jing , Li Yaofei , Zhang Yulin , Zhang Qiwei
Published: July 2023

The traditional van Krevelen diagram, the nominal oxidation of organic
carbon, and several aromaticity indexes generally considered C, H, O, N,
P, and S factors, or just C, H, and O. However, these evaluated methods
may provide incorrect interpretation for high-resolution mass data of
organics containing halogen elements. Therefore, we adapted the van
Krevelen diagram and the other indexes with halogen elements and
verified with 2235 model organics. The results demonstrated that the
modified van Krevelen diagram and the adjusted indexes were more
accurate for the analysis of mass data, either in the compound
classification or in the evaluation of oxidation state of organic
matter.
Affordable event and monthly rain samplers: Improving isotopic datasets to understand meteorological processes
Authors: Carton Cécile , Barbecot Florent , Hélie Jean-François , Horoi Viorel , Birks Jean , Picard Antoine , Mona Jorge
Published: July 2023

Stable isotopes of the water molecule have emerged as powerful tracers
of the sources and trajectories of water leading to precipitation, at
different spatial and temporal scales. However, the high cost of
commercially available rain samplers for isotopic analysis, have made
using them for high spatial resolution networks and for studies being
conducted in developing countries prohibitively expensive. We have
designed a low-cost, simple, and robust rain sampler capable of sampling
precipitation for isotopic analysis on the event and monthly scale,
based on the existing designs provided in the literature. The event rain
samplers were tested to determine the minimum amount of rainfall to
minimize isotopic fractionation, both from post-sampling evaporation and
equilibration. These new rain samplers will enable isotopic sampling of
precipitation at high spatial resolutions. All the instructions for
constructing and using these samplers are made openly accessible to the
scientific community so they can easily be repeated and adapted to the
needs of each project. This open access and low-cost methodology will
help democratize the use of isotopes for hydrological studies in
developing countries.
Investigating the Role of Genetic Variation in vgll3 and six6 in the Domestication of Gilthead seabream (Sparus aurata Linnaeus) and European seabass (Dicentrarchus labrax Linnaeus)
Authors: MOULISTANOS ARISTOTELIS , Nikolaou Theopisti , Sismanoglou Smaragda , Gkagkavouzis Konstantinos , Karaiskou Nikoleta , Antonopoulou Efthimia , Triantafyllidis Alexandros , Papakostas Spiros
Published: July 2023

Gene function conservation is crucial in molecular ecology, especially
for key traits like growth and maturation in teleost fish. The vgll3 and
six6 genes are known to influence age-at-maturity in Atlantic salmon,
but their impact on other fish species is poorly understood. Here, we
investigated the association of vgll3 and six6 in the domestication of
gilthead seabream and European seabass, both undergoing selective
breeding for growth-related traits in the Mediterranean. We analysed two
different sets of samples using two different genotyping approaches. The
first dataset comprised farmed and wild populations from Greece,
genotyped for SNPs within the genomic range of the two genes
(“gene-level genotyping”). The second dataset examined 300k to 600k
SNPs located in the chromosomes of the two genes, derived from a
meta-analysis of a Pool-Seq experiment involving farmed and wild
populations distributed widely across the Mediterranean
(“chromosome-level genotyping”). The gene-level analysis revealed a
significant effect of domestication on both genes in each species. This
finding was partially supported by the chromosome-level analysis,
identifying highly differentiated regions associated with domestication
at varying distances from the candidate genes. Noteworthy genomic
features were found, such as a CpG island in gilthead seabream and novel
candidate genes in European seabream, warranting further investigation.
These findings support a putative role of vgll3 and six6 in the
maturation and growth of gilthead seabream and European seabass,
emphasizing the need for further research on their conserved function.
FID-LCC: Fuzzy-based Intelligent Model for Lung Cancer Classification using Soft Computing Techniques
Authors: Illa Pavan Kumar , Thillaigovindan Senthil Kumar
Published: July 2023

In present scenario, 72% of all fatalities globally are caused by lung
cancer, which is the cellular fission of aberrant cells within the
lungs. With a 19% likelihood of survival, lung cancer is also known as
one of the major causes of death. A number of techniques, including
X-rays, CT scans, biopsies, and others, can be used to diagnose tumors.
The Computer Tomography (CT) scan technique is one of the most effective
methods for detecting lung cancer early among the methods mentioned
above. An early and precise diagnosis is crucial for the disease’s
treatment. The creation of multiple machine learning algorithms can
effectively forecast outcomes. The accuracy of the model in classifying
diseases, however, is significantly influenced by the model’s complexity
and the decision of the appropriate machine learning approach for the
given dataset. To address this issue, this work develops a Fuzzy-based
Intelligent Model for Lung Cancer Classification (FID-LCC). The wavelet
cleft fuzzy algorithm can be used in the model to aggregate the features
from the obtained images. Then, using Improved Binary Particle Swarm
Optimization (IBPSO), the anomalous features can be selected. Following
that, classification is accomplished using convolutional neural networks
(CNN). The simulation findings demonstrate that the proposed strategy’s
accuracy in determining the Lung Cancer is greater to other traditional
methods when the classifier’s performances are compared.
Vapor pressure deficit was not a primary limiting factor for gas exchange in an irrigated, mature dryland Aleppo pine forest
Authors: Preisler Yakir , Grünzweig José , Ahiman Ori , Amer Madi , Oz Itay , Feng Xue , Muller Jonathan D. , Ruehr Nadine , Rotenberg Eyal , Birami Benjamin , Yakir Dan
Published: July 2023

Climate change is often associated with increasing vapor pressure
deficit (VPD) and changes in soil moisture (SM). While atmospheric and
soil drying often co-occur, their differential effects on plant
functioning and productivity remain uncertain. We investigated the
divergent effects and underlying mechanisms of soil and atmospheric
drought based on continuous, in situ measurements of branch gas exchange
with automated chambers in a mature semiarid Aleppo pine forest. We
investigated the response of control trees exposed to combined
soil‒atmospheric drought (low SM, high VPD) during the rainless
Mediterranean summer and that of trees experimentally unconstrained by
soil dryness (high SM; using supplementary dry season water supply) but
subjected to atmospheric drought (high VPD). During the seasonal dry
period, branch conductance (g ), transpiration rate
(E) and net photosynthesis (A ) decreased in low-SM
trees but greatly increased in high-SM trees. The response of E and g
to the massive rise in VPD (to 7 kPa) was negative in
low-SM trees and positive in high-SM trees. These observations were
consistent with predictions based on a simple plant hydraulic model
showing the importance of plant water potential in the g
and E response to VPD. These results demonstrate that
avoiding drought on the supply side (soil moisture) and relying on plant
hydraulic regulation constrains the effects of atmospheric drought (VPD)
as a stressor on canopy gas exchange in mature pine trees under field
conditions.
Quantifying nonstationarity in ecological time series
Authors: Gee Kenneth , Munch Stephan , Rogers Tanya
Published: July 2023

Nonstationarity due to climate change, human impacts, and invasive species presents a major challenge for ecosystem forecasting, as past behavior cannot necessarily predict future behavior. While time-varying linear models may adequately detect nonstationarity in some cases, such models are often poor at forecasting and fail to correctly identify nonstationarity in nonlinear systems. Here we propose a nonlinear generalization of existing models that improves nonstationarity quantification and forecast skill. We demonstrate the effectiveness of the method in simulated datasets and experimental and field time series known to be stationary or nonstationary. Evaluating nonstationarity over subsets of the empirical time series shows that apparent nonstationarity strongly depends on the length and starting time of the series analyzed. Thus, any evaluation of nonstationarity should be conditional on a certain time window. This method could aid both in quantifying the intensity of nonstationarity in ecosystems and producing better forecasts in a changing world.
Equine cervical vertebral interbody fusion, a narrative review
Authors: Crecan Cristian Mihaita
Published: July 2023

Cervical vertebral stenotic myelopathy (CVSM) is the primary target for
spinal cord surgery in horses. Decompression of the spinal cord is the
main objective of the surgery in order to promote healing of the
compressive lesion and restoration of full function. The present study
is a narrative review of the literature concerning different cervical
stabili- sation techniques that have been used to alleviate spinal cord
compression and minimize the associated clinical symptoms. It is the aim
of this study to briefly chronologically de- scribe and compare the
success rate and long-term prognosis of each surgical procedure that has
been described, and asses future research directions. It is the author’s
opinion that in order to make the treatment less technically
challenging, to lower complications, and to improve outcomes, further
surgical approaches for equine cervical stabilization are required.
Design of Fractional-order Filters From The Fractional Chebyshev Polynomials: A Meta-Heuristic Approach
Authors: Amgad Andrew , abdelaty amr , Attia Hazem A. , Radwan Ahmed G. , Elbarawy Menna T. M. M.
Published: July 2023

The study presents a straightforward and systematic method for creating
a low-pass filter with fractional-order Chebyshev polynomials. The
method utilize the flower pollination algorithm (FPA) as a
meta-heuristic optimization technique to calculate the optimal filter
coefficients. A stability test is conducted during the optimization
process to ensure that the filter remains stable. To validate the
method’s effectiveness, the researchers implemented the Valsa
approximation of the fractional order capacitor and conducted circuit
simulations using LTspice. The results indicated that the proposed
filter design method was successful in achieving the desired magnitude
response curve.
A Review on Moringa oleifera as a Potential Biofungicide against Soil Borne Fungal Disease on Chilli Growth
Authors: Othman Nur Maizatul Idayu , Alyas Nur Dalila , Shamsuddin Aida Soraya
Published: July 2023

Moringa oleifera, or drumstick tree, is popularly known as the
miracle tree. Almost every part of this tree is scientifically proven to
be useful, be it root, bark, gum, leaf, fruit, flower, and seed. Over
the years, many scientific studies have illustrated large bioactive
compounds from Moringa oleifera extract. It is possible that the
antifungal property of Moringa oleifera is closely associated
with the presence of its bioactive compounds. However, this finding is
limited to human studies and few on agricultural importance despite
their potentiality. Nonetheless, various studies found good antifungal
activity of Moringa oleifera extract, the promising results for
the antifungal activity made it a good candidate to replace the
synthetic fungicide. In this regard, this review focuses on using
Moringa oleifera extracts as a potential biofungicide against the
soil borne fungal disease that destroys most cash crops, especially
chillies. Conclusively, this review outline the current state of
knowledge and provides a compilation of evidence-based literature on
Moringa oleifera extract to provide a reference for its potential
application as biofungicide against soil borne fungal disease.
Untitled Item Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes
Authors: Simó Rafael , Franch-Nadal Josep , Vlacho Bogdan , Real Jordi , Amado Ester , Flores Juana , Mata-Cases Manel , Ortega Emilio , Rigla Mercedes , Vallés Joan-Anton , Hernández Cristina
Published: July 2023

  

ABSTRACT

Objective: Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the present study was to evaluate whether this is an important issue in subjects with type 2 diabetes with mild or moderate non-proliferative DR (NPDR), which represent the vast majority of subjects with DR attended in the Primary Care.  

Research Design and Methods: retrospective nested case-control study of subjects with type 2 diabetes and previous mild or moderate NPDR. Using SIDIAP (“Sistema d'informació pel Desenvolupament de la Recerca a Atenció Primària”) database, we selected 1,150 individuals with EWDR and 1,150 matched controls (DR without EWDR). The main variable analyzed was the magnitude of the reduction of HbA1c in previous 12 months. The reduction of HbA1c was categorized in rapid (>1.5% reduction in < 12 months) and very rapid (>2% in <6 months). 

Results: We did not find any significant difference in HbA1c reduction between cases and controls (0.13±1.21 vs. 0.21±1.18; p=0.12). HbA1c reduction did not show significant association with worsening of DR, neither in the unadjusted analyses nor in adjusted statistical models that included the main confounding variables: duration of diabetes, baseline HbA1c, presence of hypertension and antidiabetic drugs. In addition, when stratification by baseline HbA1c was performed we did not find that those patients with higher levels of HbA1c presented higher risk to EWDR.

Conclusion: Our results suggest that the rapid reduction of HbA1c is not associated with progression of mild or moderate NPDR. 
Sodium hydroxide-induced subclinical irritation. A test for evaluating stratum corneum barrier function.
Authors: Wilhelm K P , Pasche F , Surber C , Maibach H I
Published: July 2023

This report concerns the development of a short, simple, non-invasive test for assessing sensitivity to irritant dermatitis. Application of NaOH (0.005-2.0 mol/l) to human skin resulted in significantly greater skin surface water loss directly after exposure (1-15 min) than of control (water). The increase in skin surface water loss after NaOH application was dose-dependent (0.005-0.1 mol/l) and application time-dependent (1-10 min). Application times exceeding 10 min did not further increase skin surface water loss and doses higher than 0.1 mol/l reversed the effect on skin surface water loss. 15 min after removal of the alkali, skin surface water loss baseline values were almost regained. This procedure did not cause visible reactions or discomfort for the volunteers. In a subsequent experiment, volunteers were exposed to 0.2 mol/l NaOH for 5 min on one forearm and to 1% sodium lauryl sulfate for 24 h contralaterally. Skin surface water loss after 5 min of NaOH application was significantly correlated with transepidermal water loss measurements after 24 h of sodium lauryl sulfate patch application. This is, to our knowledge, the first description of a procedure for quantifying interindividual differences in stratum corneum barrier function without inducing visible changes or causing volunteers discomfort. Use of this model should help to further investigate skin barrier function as well as to test protective devices and barrier creams.
Punctate porokeratotic keratoderma: some pathogenetic analyses of hyperproliferation and parakeratosis.
Authors: Kondo S , Shimoura T , Hozumi Y , Aso K
Published: July 2023

An 82-year-old Japanese woman had numerous palmoplantar keratotic plugs and pits, resembling 'music box spines'. Histological examination revealed compact columns of parakeratosis in the horny layer. Ultrastructually, the affected stratum corneum contained numberous variable-sized pyknotic nuclei, and cells in the stratum granulosum contained fewer keratohyalin granules. Autoradiographic analysis by [3H]thymidine [3H]TdR incorporation into epidermal cells of affected skin slices in organ culture revealed that only basal cells below the keratotic plug were stimulated to proliferate. Two-dimensional gel electrophoresis revealed that palmar keratotic plugs contained the keratin filaments that are specifically present in the plantar viable epidermal layer, or other hyperproliferative epithelial cells.
Parental education in the treatment of childhood atopic eczema.
Authors: Broberg A , Kalimo K , Lindblad B , Swanbeck G
Published: July 2023

To evaluate the role of health education in the treatment of childhood atopic eczema, an eczema school was arranged for the parents. Fifty consecutive patients (aged 4 months-6 years 2 months) with atopic eczema of varying severity were randomly assigned into two groups; one group receiving routine information given by the physician during the medical visit, and the other group also visiting a trained nurse to receive further information on eczema treatment and practical training in controlling atopic eczema. The therapeutic effect was better in the group which had received extra guidance. We suggest that systematic training in eczema treatment should be organized as an important part of eczema treatment.
Immunological phenomena in harmless mice during experimental carcinogenesis induced with long-term topical application of 7, 12-dimethylbenzanthracene (DMBA)
Authors: Gliński W , Langner A , Obalek S , Marzulli FN.
Published: July 2023

To estimate the influence of topical treatment with DMBA and induced tumors on delayed hypersensitivity, the response of spleen lymphocytes to PHA in vitro and macrophage migration inhibition with PHA were studied in DMBA-treated hairless mice. DNA synthesis and blastic transformation of cultured lymphocytes decreased after 6-12 weeks of DMBA application. Lymphocyte response to PHA gradually diminished during the experiment, as compared with control animals. Since the malignant transformation of skin tumors was not observed before 16 weeks of DMBA carcinogenesis, it seems that derangements in cellular immunity preceded the malignant proliferation. The increase in spleen weight and the absence of PHA-induced inhibition of macrophage migration in hairless mice with malignant tumors may also be related to the influence of the tumor itself on the lymphatic system of experimental animals.
Deposition of fibrinogen (FR-antigen) in skin diseases. I. Psoriasis vulgaris and Psoriasis arthropathica (with special reference to heparin-precipitable fraction)
Authors: Fyrand O , Husby G.
Published: July 2023

Twenty-five in-patients with psoriasis arthropathica (ps.a.) and 18 in-patients with psoriasis vulgaris (ps.v.) were examined for cryofibrinogen as heparin-precipitable fraction (HPF), for total fibrinogen in plasma and by immuno-fluorescence (IF) technique for FR-antigen in tissue sections of affected and unaffected skin. A control group of 14 in-patients with various non-psoriatic dermatoses were examined with if for FR-antigen in unaffected skin. Pathological quantities of HPF were found in 6% in ps.v. and in 48% in ps.a. Total fibrinogen in plasma was normal in ps.v. (365 mg%), and moderately elevated in ps.a. (471 mg%). In psoriatics, FR-antigen was found in unaffected skin ps.v. in 50%, in ps.a. in 72%. In affected skin, the figures were 67% and 84% respectively. No direct relationship could be found between the incidence and the degree of HPF, and depositions of FR-antigen in the tissue sections in the skin at the time of the examination. In the control group, no FR-antigen could be found in unaffected skin, except in one case of acne cystica, with traces of FR-antigen in a few areas of the tissue section.
Skin reactions to primary irritants in men and women
Authors: Björnberg A.
Published: July 2023

The skin reactions to skin provocation tests with 11 primary irritants were compared in 21 pairs of men and women with hand eczema, matched for age, and in 21 pairs of non-eczematous subjects. With a few exceptions, no statistically significant differences were demonstrated in the intensities of the skin reactions between the sexes. The general skin reactivity in tests with irritants seems to be the same in men and women.
Circinate erosive balanitis and HL-A 27
Authors: Lassus A , Tiilikainen A , Stubb S , Reunala T , Johansson E.
Published: July 2023

The HL-A phenotype of 17 patients with a typical clinical picture of circinate erosive balanitis was determined. Eight of the patients had other signs of Reiter's disease and 9 had balanitis alone. HL-A 27 was found to be present in 15 of the 17 cases. One patient of each group lacked this antigen. The frequency of the other histocompatibility antigens did not significantly differ from that of a Finnish control population.
A case of the Klippel-Trenaunay-Parkes Weber syndrome
Authors: Palatsi R.
Published: July 2023

An extreme case of Klippel-Trenaunay-Parkes Weber syndrome is presented. The patient had extensive cutaneous naevus involving the left side of the body and consisting of naevus flammeus, hemangioma cavernosum, and naevus verrucosus. The left extremities were longer and there were multiple arteriovenous connections between a and v subclavia and a and v radialis. Secondary symptoms were sciatica, varicosity and osteoporosis.