bluuebunny/crossref_metadata_2025 huggingface dataset:
Intra-Organizational Social Capital and Product Innovation: The Mediating Role of Realized Absorptive Capacity
Authors: Ortiz Beatriz , Donate Mario J. , Guadamillas Fátima
Published: January 2021

This paper examines the influence on product innovation of factors based on a company’s transformation and exploitation of knowledge gathered from its intra-organizational relationships. Specifically, this paper analyses the influence of intra-organizational social capital (SC) (i.e., comprised of structural, relational, and cognitive dimensions) on realized absorptive capacity (RACAP). Moreover, it analyses the mediating role of RACAP on the relationship between internal SC and product innovation. Based on a sample of companies from the Spanish biotechnological and pharmaceutical industries, two hypotheses were tested using a structural equations model and the partial least squares (PLS) technique. The results support both hypotheses, suggesting that the development of strong and tightly knit links based on a common understanding and trust among company members lead the firm to develop dynamic capabilities for transforming and exploiting knowledge acquired externally, which fosters innovation based on new product development. Research limitations, implications and future research are also discussed by the authors of the paper.
Emotional vs. Neutral Face Exploration and Habituation: An Eye-Tracking Study of Preschoolers With Autism Spectrum Disorders
Authors: Bochet Aurélie , Franchini Martina , Kojovic Nada , Glaser Bronwyn , Schaer Marie
Published: January 2021

Diminished orienting to social stimuli, and particularly to faces, is a core feature of autism spectrum disorders (ASDs). Impaired face processing has been linked to atypical attention processes that trigger a cascade of pathological development contributing to impaired social communication. The aim of the present study is to explore the processing of emotional and neutral faces using an eye-tracking paradigm (the emotional faces task) with a group of 24 children with ASD aged 6 and under and a group of 22 age-matched typically developing (TD) children. We also measure habituation to faces in both groups based on the presentation of repeated facial expressions. Specifically, the task consists of 32 pairs of faces, a neutral face and an emotional face from the same identity, shown side by side on the screen. We observe differential exploration of emotional faces in preschoolers with ASD compared with TD. Participants with ASD make fewer fixations to emotional faces than their TD peers, and the duration of their first fixation on emotional faces is equivalent to their first fixation on neutral faces. These results suggest that emotional faces may be less interesting for children with ASD. We also observe a habituation process to neutral faces in both children with ASD and TD, who looked less at neutral faces during the last quarter of the task compared with the first quarter. By contrast, TD children show increased interest in emotional faces throughout the task, looking slightly more at emotional faces during the last quarter of the task than during the first quarter. Children with ASD demonstrate neither habituation nor increased interest in the changing emotional expressions over the course of the task, looking at the stimuli for equivalent time throughout the task. A lack of increased interest in emotional faces may suggest a lack of sensitivity to changes in expression in young children with ASD.
Misidentification of Acute Psychiatric Symptoms in the Emergency Room: Clinical Experience in China
Authors: Liu Fang , Chen Jianjun , Du Yang , Jiang Wenxia , Gong Lei , Mu Jun
Published: January 2021

Introduction: Patients who come to the emergency department because of acute psychiatric symptoms are often not admitted to the correct department timely. The purpose of this study is to identify the clinical characteristics of patients with acute psychiatric symptoms in order to achieve early and correct triage in the emergency room.

Methodology: We conducted a cross-analysis of inpatients who first came to the emergency department with acute psychiatric symptoms and then admitted to the department of neurology or psychiatry between years 2012 and 2018. Among them, 70 patients were rediagnosed and retransferred, with 38 patients to the department of neurology and 32 patients to the department of psychiatry. The clinical characteristics, laboratory examination, and Neuropsychiatric Inventory (NPI) were analyzed.

Results: Patients who were rediagnosed with neurological diseases were more prone to have somatic symptoms (headache, dizziness) (P < 0.05). Because of the atypical early clinical manifestations in the emergency room, fever and positive neurological signs do not necessarily represent the diagnosis of neurological diseases. On the other hand, the absence of these manifestations does not guarantee the diagnosis of psychiatric illness. According to NPI, abnormal behaviors, changes in appetite, and sleep disturbances were more obvious in patients with neurological diseases (P < 0.05), whereas patients with psychiatric disorders often showed prominent irritability (P < 0.05).

Conclusions: Acute psychiatric symptoms are usually complex and diverse. The triage and diagnosisshould be based on multiple factors. After triage, clinical symptoms should be dynamically observed.
The Effectiveness of Mental Health Rehabilitation Services: A Systematic Review and Narrative Synthesis
Authors: Dalton-Locke Christian , Marston Louise , McPherson Peter , Killaspy Helen
Published: January 2021

Introduction: Mental health rehabilitation services provide essential support to people with complex and longer term mental health problems. They include inpatient services and community teams providing clinical input to people living in supported accommodation services. This systematic review included international studies evaluating the effectiveness of inpatient and community rehabilitation services.

Methods: We searched six online databases for quantitative studies evaluating mental health rehabilitation services that reported on one or both of two outcomes: move-on to a more independent setting (i.e. discharge from an inpatient unit to the community or from a higher to lower level of supported accommodation); inpatient service use. The search was further expanded by screening references and citations of included studies. Heterogeneity between studies was too great to allow meta-analysis and therefore a narrative synthesis was carried out.

Results: We included a total of 65 studies, grouped as: contemporary mental health rehabilitation services (n = 34); services for homeless people with severe mental health problems (n = 13); deinstitutionalization programmes (n = 18). The strongest evidence was for services for homeless people. Access to inpatient rehabilitation services was associated with a reduction in acute inpatient service use post discharge. Fewer than one half of people moved on from higher to lower levels of supported accommodation within expected timeframes.

Conclusions: Inpatient and community rehabilitation services may reduce the need for inpatient service use over the long term but more high quality research of contemporary rehabilitation services with comparison groups is required.

Review registration: This review was prospectively registered on PROSPERO (ID: CRD42019133579).
Isolation, Solitude and Social Distancing for People Who Use Drugs: An Ethnographic Perspective
Authors: Roe Laura , Proudfoot Jesse , Tay Wee Teck Joseph , Irvine Richard D. G. , Frankland Stan , Baldacchino Alexander Mario
Published: January 2021

COVID-19 has resulted in deepened states of crisis and vulnerability for people who use drugs throughout Europe and across the world, with social distancing measures having far-reaching implications for everyday life. Prolonged periods of isolation and solitude are acknowledged within much addiction literature as negatively impacting the experiences of those in recovery, while also causing harm to active users – many of whom depend on social contact for the purchasing and taking of substances, as well as myriad forms of support. Solitude, however, is proposed by the authors as inherent within some aspects of substance use, far from particular to the current pandemic. Certain forms of substance use engender solitary experience, even where use is predicated upon the presence of others. Adopting a cross-disciplinary perspective, this paper takes as its focus the urgent changes wrought by the pandemic upon everyday life for people who use drugs, drawing on recent ethnographic fieldwork with substance users in Scotland. Beyond the current crises, the paper proposes solitude, and by extension isolation, as an analytical framework for better apprehending lived experiences of substance use.
Communication and Cooperation Between the Medical Academy, Medical Association, and Local Government: Health Counseling Program After Recovery From Coronavirus Disease 2019 (COVID-19) in Daegu
Authors: Kim Yun-A , Lee Geon Ho , Lee Keun-Mi , Ko Hae-Jin , Lee DongWook , Kim A-Sol
Published: January 2021

We are currently experiencing the disaster of the COVID-19 pandemic. Since the first case of Coronavirus disease 2019 (COVID-19) was confirmed in South Korea on January 20, the number of COVID-19 cases in South Korea has been rapidly increasing until early March due to a local spread in Daegu, which is one of the eight metropolitan cities in South Korea with a population of 2.5 million. As the medical academy has social accountability as professionals, Daegu-Gyeongbuk branch of the Korean Academy of Family Medicine (Daegu-Gyeongbuk branch) developed the health counseling program for discharged COVID-19 patients. The Daegu-Gyeongbuk branch communicated with Daegu Medical Association and Daegu city for this program and incorporated available resources and capabilities as a leader of this program. This newly developed counseling program consists of medical consultations, sending healthcare brochures and medical supplies, and the appraisal at the end of the program. Not only COVID-19 related symptoms but also other psychological problems are also dealt with during consultations. This program started on March 18, and over 1,700 recovered patients have been receiving counseling as of April 28. Communication and cooperation between the medical academy, medical association, and government are essential to overcome the COVID-19 pandemic. Besides, we expect to apply this health counseling program and our model of setting this program cooperating with medical association and government to different infectious pandemic crisis.
Reduced Rate of Inpatient Hospital Admissions in 18 German University Hospitals During the COVID-19 Lockdown
Authors: Kapsner Lorenz A. , Kampf Marvin O. , Seuchter Susanne A. , Gruendner Julian , Gulden Christian , Mate Sebastian , Mang Jonathan M. , Schüttler Christina , Deppenwiese Noemi , Krause Linda , Zöller Daniela , Balig Julien , Fuchs Timo , Fischer Patrick , Haverkamp Christian , Holderried Martin , Mayer Gerhard , Stenzhorn Holger , Stolnicu Ana , Storck Michael , Storf Holger , Zohner Jochen , Kohlbacher Oliver , Strzelczyk Adam , Schüttler Jürgen , Acker Till , Boeker Martin , Kaisers Udo X. , Kestler Hans A. , Prokosch Hans-Ulrich
Published: January 2021

The COVID-19 pandemic has caused strains on health systems worldwide disrupting routine hospital services for all non-COVID patients. Within this retrospective study, we analyzed inpatient hospital admissions across 18 German university hospitals during the 2020 lockdown period compared to 2018. Patients admitted to hospital between January 1 and May 31, 2020 and the corresponding periods in 2018 and 2019 were included in this study. Data derived from electronic health records were collected and analyzed using the data integration center infrastructure implemented in the university hospitals that are part of the four consortia funded by the German Medical Informatics Initiative. Admissions were grouped and counted by ICD 10 chapters and specific reasons for treatment at each site. Pooled aggregated data were centrally analyzed with descriptive statistics to compare absolute and relative differences between time periods of different years. The results illustrate how care process adoptions depended on the COVID-19 epidemiological situation and the criticality of the disease. Overall inpatient hospital admissions decreased by 35% in weeks 1 to 4 and by 30.3% in weeks 5 to 8 after the lockdown announcement compared to 2018. Even hospital admissions for critical care conditions such as malignant cancer treatments were reduced. We also noted a high reduction of emergency admissions such as myocardial infarction (38.7%), whereas the reduction in stroke admissions was smaller (19.6%). In contrast, we observed a considerable reduction in admissions for non-critical clinical situations, such as hysterectomies for benign tumors (78.8%) and hip replacements due to arthrosis (82.4%). In summary, our study shows that the university hospital admission rates in Germany were substantially reduced following the national COVID-19 lockdown. These included critical care or emergency conditions in which deferral is expected to impair clinical outcomes. Future studies are needed to delineate how appropriate medical care of critically ill patients can be maintained during a pandemic.
Face Masks During the COVID-19 Pandemic: A Simple Protection Tool With Many Meanings
Authors: Martinelli Lucia , Kopilaš Vanja , Vidmar Matjaž , Heavin Ciara , Machado Helena , Todorović Zoran , Buzas Norbert , Pot Mirjam , Prainsack Barbara , Gajović Srećko
Published: January 2021

Wearing face masks is recommended as part of personal protective equipment and as a public health measure to prevent the spread of coronavirus disease 2019 (COVID-19) pandemic. Their use, however, is deeply connected to social and cultural practices and has acquired a variety of personal and social meanings. This article aims to identify the diversity of sociocultural, ethical, and political meanings attributed to face masks, how they might impact public health policies, and how they should be considered in health communication. In May 2020, we involved 29 experts of an interdisciplinary research network on health and society to provide their testimonies on the use of face masks in 20 European and 2 Asian countries (China and South Korea). They reflected on regulations in the corresponding jurisdictions as well as the personal and social aspects of face mask wearing. We analyzed those testimonies thematically, employing the method of qualitative descriptive analysis. The analysis framed the four dimensions of the societal and personal practices of wearing (or not wearing) face masks: individual perceptions of infection risk, personal interpretations of responsibility and solidarity, cultural traditions and religious imprinting, and the need of expressing self-identity. Our study points to the importance for an in-depth understanding of the cultural and sociopolitical considerations around the personal and social meaning of mask wearing in different contexts as a necessary prerequisite for the assessment of the effectiveness of face masks as a public health measure. Improving the personal and collective understanding of citizens' behaviors and attitudes appears essential for designing more effective health communications about COVID-19 pandemic or other global crises in the future.

   To wear a face mask or not to wear a face mask?

   Nowadays, this question has been analogous

   to the famous line from Shakespeare's Hamlet:

   “To be or not to be, that is the question.”

   This is a bit allegorical,

   but certainly not far from the current circumstances

   where a deadly virus is spreading amongst us... Vanja Kopilaš, Croatia.
Online Multi-Domain Geriatric Health Screening in Urban Community Dwelling Older Malaysians: A Pilot Study
Authors: Alex Deepa , Fauzi Adhhani Binti , Mohan Devi
Published: January 2021

Introduction: With a rapidly aging population, the Malaysian health care system needs to develop solutions to address the lack of resources that are required for the assessment of the older person. The complex nature of geriatric syndromes coupled with the occurrence of multiple comorbid illnesses with aging, make geriatric assessment a resource intensive process. Digital health solutions could play an important role in supporting existing health care systems, especially in low and middle income countries, with limited speciality services in geriatrics.

Objective: This is a pilot study aimed at screening for geriatric syndromes through self-administered online surveys in urban community dwelling older Malaysians and assessing the pattern of geriatric syndromes in relation to the frailty status of the study participants.

Methods: This is a cross-sectional pilot study conducted between July-September 2020. Community dwelling adults aged 60 years and over were invited to take part in an online survey. Information on sociodemographic variables, comorbidities, and the self-reported results of geriatric syndromes (frailty, sarcopenia, anorexia of aging, urinary incontinence, falls, and cognitive impairment), were collected through the survey.

Results: Data was collected for 162 participants over a period of 2 months. The mean (SD) age of the respondents was 66.42 (5.25) years with 64.9% females. Majority of the respondents were of Chinese ethnic origin (67.9%) and had tertiary level of education (75.9%). The average time taken by participants to complete the survey was 16.86 min. Urinary incontinence was the highest reported geriatric syndrome (55.1%) followed by falls (37.6%), anorexia of aging (32.8%), cognitive impairment (27.8%), and sarcopenia (8.3%). Frailty was detected in 4.5% of the study population. Loss of weight in the previous year was the highest reported component of the frailty assessment tool. The presence of sarcopenia, anorexia of aging, poor/fair self-rated health, urinary incontinence, and multimorbidity were significantly higher in older adults who were frail or prefrail.

Conclusion: Screening for geriatric syndromes through online surveys is a feasible approach to identify older adults in the community who are likely to benefit from geriatric assessment. However, the demographic profile of the older population that are accessible through such digital platforms is limited.
An Evaluation of the Impact of Monetary Easing Policies in Times of a Pandemic
Authors: Li Ying , Sun Yunpeng , Chen Mengya
Published: January 2021

This article tests five major economies of the world, United Kingdom, Japan, Brazil, Chin and lastly, India, for the changes in the monetary policy decisions that have been implemented following the Covid-19 outbreak. The assessment was undertaken in the form of an event study analysis, further substantiated with a regression analysis conducted for exploring the significance of CPI and real GDP in predicting the policy interest rates in the economy. The results of the event study analysis presented that the abnormal changes in the interest rates were statistically significant in the case of the United Kingdom, Brazil, and China, while the abnormal changes were found to be statistically insignificant in the case of India and Japan.
EmotionNet Nano: An Efficient Deep Convolutional Neural Network Design for Real-Time Facial Expression Recognition
Authors: Lee James Ren , Wang Linda , Wong Alexander
Published: January 2021

While recent advances in deep learning have led to significant improvements in facial expression classification (FEC), a major challenge that remains a bottleneck for the widespread deployment of such systems is their high architectural and computational complexities. This is especially challenging given the operational requirements of various FEC applications, such as safety, marketing, learning, and assistive living, where real-time requirements on low-cost embedded devices is desired. Motivated by this need for a compact, low latency, yet accurate system capable of performing FEC in real-time on low-cost embedded devices, this study proposes EmotionNet Nano, an efficient deep convolutional neural network created through a human-machine collaborative design strategy, where human experience is combined with machine meticulousness and speed in order to craft a deep neural network design catered toward real-time embedded usage. To the best of the author’s knowledge, this is the very first deep neural network architecture for facial expression recognition leveraging machine-driven design exploration in its design process, and exhibits unique architectural characteristics such as high architectural heterogeneity and selective long-range connectivity not seen in previous FEC network architectures. Two different variants of EmotionNet Nano are presented, each with a different trade-off between architectural and computational complexity and accuracy. Experimental results using the CK + facial expression benchmark dataset demonstrate that the proposed EmotionNet Nano networks achieved accuracy comparable to state-of-the-art FEC networks, while requiring significantly fewer parameters. Furthermore, we demonstrate that the proposed EmotionNet Nano networks achieved real-time inference speeds (e.g., >25 FPS and >70 FPS at 15 and 30 W, respectively) and high energy efficiency (e.g., >1.7 images/sec/watt at 15 W) on an ARM embedded processor, thus further illustrating the efficacy of EmotionNet Nano for deployment on embedded devices.
Water-in-Oleogel Emulsions—From Structure Design to Functionality
Authors: Wijarnprecha Khakhanang , de Vries Auke , Sonwai Sopark , Rousseau Dérick
Published: January 2021

The development of water-in-oleogel (W/Og) emulsions is highlighted, with focus placed on the key properties dictating the structuring ability of both the continuous oleogelled and dispersed phases present. The gelling ability of oleogelators is distinguished by the formation of crystalline structures, polymeric strands, or tubules. Once a dispersed aqueous phase is introduced, droplet stabilization may occur via oleogelator adsorption onto the surface of the dispersed droplets, the formation of a continuous gel network, or a combination of both. Surface-active species (added or endogenous) are also required for effective W/Og aqueous phase dispersion and stabilization. Processing conditions, namely temperature-time-shear regimes, are also discussed given their important role on dispersed droplet and oleogel network formation. The effects of many factors on W/Og emulsion formation, rheology, and stability remain virtually unknown, particularly the role of dispersed droplet size, gelation, and clustering as well as the applicability of the active filler concept to foods. This review explores some of these factors and briefly mentions possible applications of W/Og emulsions.
Lessons Learned From the Battlefield and Applicability to Veterinary Medicine—Part 1: Hemorrhage Control
Authors: Edwards Thomas H. , Dubick Michael A. , Palmer Lee , Pusateri Anthony E.
Published: January 2021

In humans, the leading cause of potentially preventable death on the modern battlefield is undoubtedly exsanguination from massive hemorrhage. The US military and allied nations have devoted enormous effort to combat hemorrhagic shock and massive hemorrhage. This has yielded numerous advances designed to stop bleeding and save lives. The development of extremity, junctional and truncal tourniquets applied by first responders have saved countless lives both on the battlefield and in civilian settings. Additional devices such as resuscitative endovascular balloon occlusion of the aorta (REBOA) and intraperitoneal hemostatic foams show great promise to address control the most difficult forms (non-compressible) of hemorrhage. The development of next generation hemostatic dressings has reduced bleeding both in the prehospital setting as well as in the operating room. Furthermore, the research and fielding of antifibrinolytics such as tranexamic acid have shown incredible promise to ameliorate the effects of acute traumatic coagulopathy which has led to significant morbidity and mortality in service members. Advances from lessons learned on the battlefield have numerous potential parallels in veterinary medicine and these lessons are ripe for translation to veterinary medicine.
An Insight Into COVID-19: A 21st Century Disaster and Its Relation to Immunocompetence and Food Antioxidants
Authors: Siddique Faisal , Abbas Rao Zahid , Mansoor Muhammad Khalid , Alghamdi Etab Saleh , Saeed Muhammad , Ayaz Muhammad Mazhar , Rahman Moazur , Mahmood Muhammad Shahid , Iqbal Asif , Manzoor Maida , Abbas Asghar , Javaid Asif , Hussain Irshad
Published: January 2021

Coronavirus Disease 2019 (COVID-19) ranks third in terms of fatal coronavirus diseases threatening public health, coming after SARS-CoV (severe acute respiratory syndrome coronavirus), and MERS-CoV (Middle East respiratory syndrome coronavirus). SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) causes COVID-19. On January 30, 2020, the World Health Organization (WHO) announced that the current outbreak of COVID-19 is the sixth global health emergency. As of December 3, 2020, 64 million people worldwide have been affected by this malaise, and the global economy has experienced a loss of more than $1 trillion. SARS-CoV-2 is a positive-sense single-stranded RNA virus belonging to the Betacoronavirus genus. The high nucleotide sequence identity of SARS-CoV-2 with the BatCoV RaTG13 genome has indicated that bats could be the possible host of SARS-CoV-2. SARS-CoV-2 penetrates the host cell via binding its spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor, which is similar to the mechanisms of SARS-CoV and MERS-CoV. COVID-19 can spread from person to person via respiratory droplets and airborne and contaminated fomites. Moreover, it poses a significant risk to smokers, the elderly, immunocompromised people, and those with preexisting comorbidities. Two main approaches are used to control viral infections, namely, vaccination, and biosecurity. Studies to analyze the antigenicity and immunogenicity of SARS-CoV-2 vaccine candidates are underway, and few vaccines may be available in the near future. In the current situation, the Human Biosecurity Emergency (HBE) may be the only way to cope effectively with the novel SARS-CoV-2 strain. Here, we summarize current knowledge on the origin of COVID-19 as well as its epidemiological relationship with humans and animals, genomic resemblance, immunopathogenesis, clinical-laboratory signs, diagnosis, control and prevention, and treatment. Moreover, we discuss the interventional effects of various nutrients on COVID-19 in detail. However, multiple possibilities are explored to fight COVID-19, and the greatest efforts targeted toward finding an effective vaccine in the near future. Furthermore, antioxidants, polyphenols, and flavonoids, both synthetic and natural, could play a crucial role in the fight against COVID-19.
Functional Characterization of Two Thioredoxin Proteins of Toxoplasma gondii Using the CRISPR-Cas9 System
Authors: Zhang Zhi-Wei , Li Ting-Ting , Wang Jin-Lei , Liang Qin-Li , Zhang Hai-Sheng , Sun Li-Xiu , Zhu Xing-Quan
Published: January 2021

Toxoplasmosis caused by infection withToxoplasma gondiiis an important parasitic zoonosis with a worldwide distribution. In this study, we examined the functions of two thioredoxins (namely CTrp26 and CTrx1) ofT. gondiitachyzoites by generation of HA tag strains or gene deficient parasites in Type I RH strain (ToxoDB#10). Immunofluorescence analysis (IFA) was used to investigate the subcellular localization of the thioredoxins (Trxs). Results of IFA showed that both CTrp26 and CTrx1 were located in the cytoplasm ofT. gondii. Functional characterizations of CTrp26 and CTrx1-deficient parasites were performed by plaque assay, intracellular replication, egress, H2O2resistance, detection of reactive oxygen species (ROS) level and total antioxidant capacity (T-AOC) assaysin vitro, as well as mouse infectionin vivo. Our results showed that deletion of CTrp26 or CTrx1 did not influence the ability ofT. gondiiRH strain to replicate, egress, form plaque, resist H2O2exposure, maintain the ROS level, and T-AOC, and also did not serve as virulence factors in Kunming mice. Taken together, these results provide new properties of the two Trxs. Although they are not essential for RH strain, they may have roles in other strains of this parasite due to their different expression patterns, which warrants future research.
Recommended vs. Practice: Smallholder Fertilizer Decisions in Central Myanmar
Authors: Thar So Pyay , Farquharson Robert J. , Ramilan Thiagarajah , Coggins Sam , Chen Deli
Published: January 2021

Agriculture in Myanmar has substantial development potential given the abundance of land, water, and labor resources in the country. Despite this, agricultural productivity in Myanmar is low and farm incomes are amongst the lowest in Asia. The underperformance of crops and low yield is widely reported to be due to low fertilizer use by smallholders. This study investigated the perceptions of smallholders about fertilizer use for cereal crops by considering their motives and decision making. We reported results of a 600 smallholders’ survey and tested whether the reportedly low fertilizer use by smallholders is generally true for central Myanmar. We compared the fertilizer application timing against recommended “good management practices”. Among the surveyed rice farmers, the average fertilizer applied was much higher than previously reported national average fertilizer rates while the majority of the surveyed maize farmers were found to be applying less than the national recommended rates. With respect to timing, nearly half of the surveyed smallholders were not applying nitrogen at the estimated panicle initiation stage, which is often crucial to increase yield, and the majority (82%) of smallholders were applying phosphorus throughout the growth stages, when earlier applications are desirable. Smallholders may be able to reduce the cost of labor by reducing the number of P applications and avoiding late applications.
Weeds Hosting the Soybean Cyst Nematode (Heterodera glycines Ichinohe): Management Implications in Agroecological Systems
Authors: Rocha Leonardo F. , Gage Karla L. , Pimentel Mirian F. , Bond Jason P. , Fakhoury Ahmad M.
Published: January 2021

The soybean cyst nematode (SCN; Heterodera glycines Ichinohe) is a major soybean-yield-limiting soil-borne pathogen, especially in the Midwestern US. Weed management is recommended for SCN integrated management, since some weed species have been reported to be hosts for SCN. The increase in the occurrence of resistance to herbicides complicates weed management and may further direct ecological–evolutionary (eco–evo) feedbacks in plant–pathogen complexes, including interactions between host plants and SCN. In this review, we summarize weed species reported to be hosts of SCN in the US and outline potential weed–SCN management interactions. Plants from 23 families have been reported to host SCN, with Fabaceae including most host species. Out of 116 weeds hosts, 14 species have known herbicide-resistant biotypes to 8 herbicide sites of action. Factors influencing the ability of weeds to host SCN are environmental and edaphic conditions, SCN initial inoculum, weed population levels, and variations in susceptibility of weed biotypes to SCN within a population. The association of SCN on weeds with relatively little fitness cost incurred by the latter may decrease the competitive ability of the crop and increase weed reproduction when SCN is present, feeding back into the probability of selecting for herbicide-resistant weed biotypes. Therefore, proper management of weed hosts of SCN should be a focus of integrated pest management (IPM) strategies to prevent further eco–evo feedbacks in the cropping system.
Free and Microencapsulated Essential Oils Incubated In Vitro: Ruminal Stability and Fermentation Parameters
Authors: Amin Nida , Tagliapietra Franco , Arango Sheyla , Guzzo Nadia , Bailoni Lucia
Published: January 2021

Essential oils (EOs) are generally considered as an alternative to antibiotics because of their antimicrobial properties. Despite their vast variety, their volatile nature poses hindrance on their use in animal feeds, which demands a high degree of stability. This study aimed at testing the susceptibility of three EOs (mixtures of EOs based on cinnamaldehyde, named Olistat-Cyn, Olistat-G, and Olistat-P) in two forms (free: fEOs; and microencapsulated: mEOs) to in vitro ruminal degradation using the Ankom DaisyII technique. The microencapsulation was made using a matrix based on vegetable hydrogenated fatty acids. Compared to the fEOs, which were completely degraded within 48 h of in vitro incubation, the mEOs showed a low ruminal disappearance. In comparison to the fermentation profile at 0 h, Olistat-G significantly decreased the pH and the total protozoa number after 48 h, while the total VFAs increased. However, the other EOs (Olistat-Cyn and Olistat-P) had no effect on the rumen fermentation parameters. In conclusion, the protection of EOs from ruminal degradation by microencapsulation was found to be very effective to ensure rumen by-pass. Among the EOs, Olistat-G was capable of changing rumen fermentation, potentially reducing methane emissions.
Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate
Authors: Dagnell Markus , Cheng Qing , Arnér Elias S.J.
Published: January 2021

Protein tyrosine phosphatases (PTPs) can be regulated by several redox-dependent mechanisms and control growth factor-activated receptor tyrosine kinase phosphorylation cascades. Reversible oxidation of PTPs is counteracted by reductive enzymes, including thioredoxin (Trx) and Trx-related protein of 14 kDa (TRP14), keeping PTPs in their reduced active states. Different modes of oxidative inactivation of PTPs concomitant with assessment of activating reduction have been little studied in direct comparative analyses. Determining PTP1B activities, we here compared the potency of inactivation by bicarbonate-assisted oxidation using H2O2 with that of polysulfide-mediated inactivation. Inactivation of pure PTP1B was about three times more efficient with polysulfides as compared to the combination of bicarbonate and H2O2. Bicarbonate alone had no effect on PTP1B, neither with nor without a combination with polysulfides, thus strengthening the notion that bicarbonate-assisted H2O2-mediated inactivation of PTP1B involves formation of peroxymonocarbonate. Furthermore, PTP1B was potently protected from polysulfide-mediated inactivation by either TRP14 or Trx1, in contrast to the inactivation by bicarbonate and H2O2. Comparing reductive activation of polysulfide-inactivated PTP1B with that of bicarbonate- and H2O2-treated enzyme, we found Trx1 to be more potent in reactivation than TRP14. Altogether we conclude that inactivation of PTP1B by polysulfides displays striking qualitative differences compared to that by H2O2 together with bicarbonate, also with regard to maintenance of PTP1B activity by either Trx1 or TRP14.
Antioxidant Effects of Turmeric Leaf Extract against Hydrogen Peroxide-Induced Oxidative Stress In Vitro in Vero Cells and In Vivo in Zebrafish
Authors: Kim Sera , Kim Mingyeong , Kang Min-Cheol , Lee Hyun Hee L. , Cho Chi Heung , Choi Inwook , Park Yongkon , Lee Sang-Hoon
Published: January 2021

Oxidative stress, caused by the excessive production of reactive oxygen species (ROS), results in cellular damage. Therefore, functional materials with antioxidant properties are necessary to maintain redox balance. Turmeric leaves (Curcuma longa L. leaves; TL) are known to have antioxidant properties, including 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and Hydrogen peroxide (H2O2) radical scavenging activity in several studies. The antioxidant effects of TL come from distinct bioactive compounds, such as curcumin, total phenolic compounds, and flavonoids. Therefore, in this study, the antioxidant effects of a water extract of TL (TLE) against H2O2 treatment were assessed in vitro Vero cells and in vivo zebrafish models. The intracellular ROS generation and the proportion of sub-G1 phase cells were evaluated in H2O2- or/and TLE-treated Vero cells to measure the antioxidant activity of TLE. TLE showed outstanding intracellular ROS scavenging activity and significantly decreased the proportion of cells in the sub-G1 phase in a dose-dependent manner. Furthermore, cell death, ROS generation, and lipid peroxidation in the H2O2-treated zebrafish model were attenuated as a consequence of TLE treatment. Collectively, the results from this study suggested that TLE may be an alternative material to relieve ROS generation through its antioxidant properties or a suitable material for the application in a functional food industry.
Environmental Impact of Sulfate-Reducing Bacteria, Their Role in Intestinal Bowel Diseases, and Possible Control by Bacteriophages
Authors: Kushkevych Ivan , Dordević Dani , Vítězová Monika , Rittmann Simon K.-M. R.
Published: January 2021

Sulfate-reducing bacteria (SRB) represent a group of prokaryotic microorganisms that are widely spread in the anoxic environment (seabed, riverbed and lakebed sediments, mud, intestinal tract of humans and animals, metal surfaces). SRB species also have an impact on processes occurring in the intestinal tract of humans and animals, including the connections between their presence and inflammatory bowel disease (IBD). Since these SRB can develop antimicrobial resistance toward the drugs, including antibiotics and antimicrobial agents, bacteriophages could represent an additional potential effective treatment. The main objectives of the review were as follows: (a) to review SRB (both from intestinal and environmental sources) regarding their role in intestinal diseases as well as their influence in environmental processes; and (b) to review, according to literature data, the influence of bacteriophages on SRB and their possible applications. Since SRB can have a significant adverse influence on industry as well as on humans and animals health, phage treatment of SRB can be seen as a possible effective method of SRB inhibition. However, there are relatively few studies concerning the influence of phages on SRB strains. Siphoviridae and Myoviridae families represent the main sulfide-producing bacteria phages. The most recent studies induced, by UV light, bacteriophages from Desulfovibrio vulgaris NCIMB 8303 and Desulfovibrio desulfuricans ATCC 13541. Notwithstanding costly and medically significant negative impacts of phages on SRB, they have been the subject of relatively few studies. The current search for alternatives to chemical biocides and antibiotics has led to the renewed interest in phages as antibacterial biocontrol and therapeutic agents, including their use against SRB. Hence, phages might represent a promising treatment against SRB in the future.
Integration of Freeplay-Induced Limit Cycles Based On a State Space Iterating Scheme
Authors: Wang Xiangyu , Wu Zhigang , Yang Chao
Published: January 2021

Time integration is commonly used to obtain accurate system responses, such as the limit cycle oscillations (LCOs) for an aeroelastic system with freeplay. However, the integrations that start with various initial conditions (I.C.s) are usually studied case by case, so only a few system states can possibly be focused on. This paper proposes a state space iterating (SSI) scheme to find LCO solutions using time integration by using another method. First, a large number of arbitrary I.C. cases are used for time integrations, but only a very short integration time is required for each I.C. case. Second, system behaviors are depicted visually through a method that combines a modified Poincaré map and Lorenz map, in which the LCO solutions are found as fixed points via visual inspections. To verify the SSI scheme’s ability to find LCOs, a typical plunge–pitch wing section is established numerically. Time integrations with both the classic scheme and the proposed SSI scheme are carried out. The LCO results of the SSI scheme are well-aligned with those from the classic scheme. The SSI scheme visualizes the patterns of system responses using arbitrary I.C. cases and analyzes the LCO stability, which provides more mathematical insights into an aeroelastic system with freeplay.
Genetic Algorithm Based Deep Learning Neural Network Structure and Hyperparameter Optimization
Authors: Lee Sanghyeop , Kim Junyeob , Kang Hyeon , Kang Do-Young , Park Jangsik
Published: January 2021

Alzheimer’s disease is one of the major challenges of population ageing, and diagnosis and prediction of the disease through various biomarkers is the key. While the application of deep learning as imaging technologies has recently expanded across the medical industry, empirical design of these technologies is very difficult. The main reason for this problem is that the performance of the Convolutional Neural Networks (CNN) differ greatly depending on the statistical distribution of the input dataset. Different hyperparameters also greatly affect the convergence of the CNN models. With this amount of information, selecting appropriate parameters for the network structure has became a large research area. Genetic Algorithm (GA), is a very popular technique to automatically select a high-performance network architecture. In this paper, we show the possibility of optimising the network architecture using GA, where its search space includes both network structure configuration and hyperparameters. To verify the performance of our Algorithm, we used an amyloid brain image dataset that is used for Alzheimer’s disease diagnosis. As a result, our algorithm outperforms Genetic CNN by 11.73% on a given classification task.
Numerical Investigation on the Influence of Surface Flow Direction on the Heat Transfer Characteristics in a Granite Single Fracture
Authors: Gao Xuefeng , Zhang Yanjun , Hu Zhongjun , Huang Yibin
Published: January 2021

As fluid passes through the fracture of an enhanced geothermal system, the flow direction exhibits distinct angular relationships with the geometric profile of the rough fracture. This will inevitably affect the heat transfer characteristics in the fracture. Therefore, we established a hydro-thermal coupling model to study the influence of the fluid flow direction on the heat transfer characteristics of granite single fractures and the accuracy of the numerical model was verified by experiments. Results demonstrate a strong correlation between the distribution of the local heat transfer coefficient and the fracture morphology. A change in the flow direction is likely to alter the transfer coefficient value and does not affect the distribution characteristics along the flow path. Increasing injection flow rate has an enhanced effect. Although the heat transfer capacity in the fractured increases with the flow rate, a sharp decline in the heat extraction rate and the total heat transfer coefficient is also observed. Furthermore, the model with the smooth fracture surface in the flow direction exhibits a higher heat transfer capacity compared to that of the fracture model with varying roughness. This is attributed to the presence of fluid deflection and dominant channels.
Evaluation of Anticipatory Postural Adjustment before Quantified Weight Shifting—System Development and Reliability Test
Authors: Liaw Jiunn-Woei , Chen Rou-Shayn , Chen Vincent Chiun-Fan , Wang Yan-Ru , Chan Hsiao-Lung , Chang Ya-Ju
Published: January 2021

Anticipatory postural adjustment (APA) existed before a self-induced perturbation is an important motor control skill for balance and gait initiation, but cannot be easily monitored. During proactive balance test, a self-initiated weight shifting is produced. This might be an optimal paradigm for APA measurement. The purpose of this study was to investigate if APAs existed in the proactive balance test which consists of quantifiable weight shifting. The feature and reliability of the APAs were also evaluated. We firstly built a proactive balance test program on the commercially available Wii balance board. The program could generate adjustable target direction and distance for guiding subjects performing quantifiable weight shifting. The center of pressure (COP) was recorded and analyzed for balance-related variables (path length, path time, and direction error) and APA-related variables (APA time, APA distance, and APA correction). The results showed that APAs could be detected in every testing trial. Adequate to good reliability in both balance and APA-related variables were found. This study proved the feasibility of quantifying APA during proactive balance tests and its feasibility for clinical- and home-based measurements.
A Virtual Experiment for Learning the Principle of Daniell Cell Based on Augmented Reality
Authors: Tarng Wernhuar , Lin Yu-Jun , Ou Kuo-Liang
Published: January 2021

Chemistry is a science emphasizing both theory and experimentation. After learning the theoretical knowledge, experimental operation can help students understand chemical concepts and transform them into practical knowledge. Considering the safety issue and the lack of teaching time and experimental equipment, some teachers often choose to demonstrate an experiment instead of letting students conduct it by themselves. This may affect their learning motivation as well as the construction of chemical concepts and hands-on skills. This study combined the augmented reality (AR) technology with the operating principle of the Daniell cell to develop a virtual experiment for the application in high school chemistry courses. Students can conduct the virtual experiment using mobile devices by selecting the required equipment and materials from a deck of cards to set up the experimental environment. In the virtual experiment, students can use the galvanometer to measure the current after mounting the salt bridge on the beakers containing zinc sulfate and copper sulfate solutions. They can also see the change of molecular structures and movement of electrons and ions during the redox reactions to understand the important concepts and knowledge. An empirical research has been performed, and the analytical results show that both the virtual experiment and the real experiment could improve students’ learning achievement, but the former was more effective for the low-achievement students because they could explore autonomously to enhance cognition by observing the submicroscopic view of the redox reactions. The post-test results show that the average score of the low-achievement students in the experimental group (41.60) was significantly higher than that of the control group (27.67). Questionnaire results reveal that most students were satisfied with the learning contents, user interface, learning motivation, system reality, and practicality of the virtual experiment, and the average satisfaction score was 3.98 out of 5. The application of virtual experiments is not limited by time or space. Students only need to download the application (APP) software and print out the AR cards to practice at home, so it is suitable for large-scale promotion in rural areas.