bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of holistic and integrated LCSA: Case study on laminated veneer lumber production in Central Germany
Authors: Zeug Walther , Bezama Alberto , Thrän Daniela
Published: October 2022

Purpose

We have to transform our societies and economic systems towards social, ecological, and economic (holistic) sustainability. Bioeconomy (BE) can contribute to sustainable development by substituting fossil-based products with renewable ones; however, sustainability is not intrinsic to BE.

Methods

Therefore, we developed a holistic and integrated life cycle sustainability assessment (HILCSA) method containing 91 indicators, implemented in openLCA, using the Ecoinvent and SoCa database, and addressing 15 out of 17 Sustainable Development Goals. We applied it for the first time to show its capabilities by assessing the holistic sustainability of laminated veneer lumber (LVL) relative to hot-rolled steel beams.

Results, discussion

Our results indicate that renewable bio-based construction materials can have a better holistic sustainability than fossil-based products for nearly all indicators, by less stressing the environment, having a less negative impact on society and being economically more efficient. However, fossil-based components of LVL such as phenolic resin are main contributors of negative impacts and should be reduced and replaced. Renewable resources from agriculture and forestry have significant impacts on land use (change).

Conclusions

HILCSA demonstrates to be able to provide comprehensive sustainability assessments as well as aggregated results. BE substitutes indeed can improve sustainability; however, sustainability assessments and HILCSA need to be further developed to allow conclusions to be drawn about absolute sustainability of BE.
Neural-Symbolic Ensemble Learning for early-stage prediction of critical state of Covid-19 patients
Authors: Fadja Arnaud Nguembang , Fraccaroli Michele , Bizzarri Alice , Mazzuchelli Giulia , Lamma Evelina
Published: October 2022

Recently, Artificial Intelligence (AI) and Machine Learning (ML) have been successfully applied to many domains of interest including medical diagnosis. Due to the availability of a large quantity of data, it is possible to build reliable AI systems that assist humans in making decisions. The recent Covid-19 pandemic quickly spread over the world causing serious health problems and severe economic and social damage. Computer scientists are actively working together with doctors on different ML models to diagnose Covid-19 patients using Computed Tomography (CT) scans and clinical data. In this work, we propose a neural-symbolic system that predicts if a Covid-19 patient arriving at the hospital will end in a critical condition. The proposed system relies on Deep 3D Convolutional Neural Networks (3D-CNNs) for analyzing lung CT scans of Covid-19 patients, Decision Trees (DTs) for predicting if a Covid-19 patient will eventually pass away by analyzing its clinical data, and a neural system that integrates the previous ones using Hierarchical Probabilistic Logic Programs (HPLPs). Predicting if a Covid-19 patient will end in a critical condition is useful for managing the limited number of intensive care at the hospital. Moreover, knowing early that a Covid-19 patient could end in serious conditions allows doctors to gain early knowledge on patients and provide special treatment to those predicted to finish in critical conditions. The proposed system, entitled Neural HPLP, obtains good performance in terms of area under the receiver operating characteristic and precision curves with values of about 0.96 for both metrics. Therefore, with Neural HPLP, it is possible not only to efficiently predict if Covid-19 patients will end in severe conditions but also possible to provide an explanation of the prediction. This makes Neural HPLP explainable, interpretable, and reliable.
Improving the wear resistance of copper tools for pressure die casting by laser melt injection
Authors: Warneke Philipp , Bohlen Annika , Seefeld Thomas
Published: October 2022

Highly conductive copper alloys are used for various tools in casting and welding technology. In pressure die casting, copper alloys are used for pistons pressing the metal melt into a die. The high thermal conductivity of these alloys allows short process times as a result of high cooling rates. Due to a poor wear resistance, wear occurs on the running surface of the pistons causing the metal melt to spurt out of the shot sleeve. In order to improve the service life of the pistons, a new approach was taken: a reinforcement of the copper alloys with fused tungsten carbide (FTC) particles by laser melt injection (LMI) at high process velocities. FTC provides a hardness between 2700 HV 0.1 and 3500 HV 0.1. During LMI, a melt pool is induced on the substrate by a laser beam and a filler material is injected into this melt pool by a powder nozzle. In contrast to laser cladding, the filler material remains in the solid state and the substrate works as matrix material. Thereby, specific material properties of the substrate—e.g. a high thermal conductivity—can be preserved within the surface layer. It was shown that the FTC particle reinforcement reduced the wear by 69–75%. Abrasion and adhesion were identified as the dominant wear mechanisms. The run-in behavior of FTC particle reinforced and non-reinforced parts was determined.
Micro structuring tool steel components using Precise Electrochemical Machining (PECM)
Authors: Wali Abdul , Platt Timo , Meijer Alexander , Biermann Dirk
Published: October 2022

Surface structuring offers great potential for modifying frictional properties for various applications, such as complex forming processes like sheet-bulk metal forming. The production of surface structures in micrometre range is challenging for manufacturing processes in particular when machining hard-to-cut materials like hardened tool steels. Precise electrochemical machining (PECM) has great potential for surface structuring and shaping of metallic materials regardless of their hardness with high surface quality and comparatively very short process times, especially when structuring large areas and batches. Micro structuring of hardened tool steel surfaces using PECM is investigated in this paper. Surfaces of high-speed tool steel and hot-work tool steel are structured using a commercial PECM machine with neutral solution of NaNO$$_3$$

3

as electrolyte. In a process sequence, PECM tools were manufactured in a first step producing selected structures by high-feed milling (HFM) and micromilling (MM). In a further process step, the negative shape of these complex structures was machined using the PECM process. Through this process chain, new types of structures can be generated which have different tribological properties than their corresponding negative shapes of HFM and MM structures. Tribological behaviour and wear properties of the structured surfaces are investigated through ring compression test (RCT).
Osteoclast Recycling and the Rebound Phenomenon Following Denosumab Discontinuation
Authors: Kim Albert S. , Girgis Christian M. , McDonald Michelle M.
Published: October 2022

Purpose of Review

Inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) with denosumab is an effective treatment in a number of conditions including osteoporosis where suppression of bone resorption is desired. However, denosumab discontinuation is associated with rebound increase in bone resorption and subsequent loss in bone mass and a rapid return to baseline fracture risk. We review recent data on the rebound increase in bone resorption following denosumab discontinuation and the potential mechanisms behind this phenomenon.

Recent Findings

Osteoclasts have been considered to be highly specialised cells that undergo apoptosis after fulfilling their function of bone resorption. However, recent studies suggest that osteoclasts are longer lived cells which migrate through vasculature and are capable of undergoing fission into a novel cell type (the osteomorph) and re-fusion in a process termed osteoclast recycling.

The life cycle of the osteoclast is more complex than previously appreciated. Osteoclast recycling provides a novel mechanistic framework to examine changes in osteoclast biology in response to treatment of bone diseases and provides an exciting new avenue towards personalised medicine.
Spiritualität und kultursensible Begleitung am Lebensende
Authors: Wasner Maria
Published: October 2022

Wenn die Diagnose einer schweren unheilbaren Erkrankung gestellt wird, bricht für die meisten Menschen eine Welt zusammen, nichts ist mehr wie es vorher war. Dies kann einen allumfassenden Schmerz auslösen. Cicely Saunders, die Begründerin der modernen Hospizbewegung, prägte dafür den Begriff des „total pain“: Schmerz, der sich auf körperlicher oder psychischer Ebene äußert, der Beziehungen auf den Prüfstand stellt (sozialer Schmerz) und der an den eigenen spirituellen Überzeugungen (spiritueller Schmerz) zweifeln lässt. Ziel der Hospiz- und Palliativversorgung ist daher der Erhalt oder die Verbesserung der Lebensqualität von schwerkranken und sterbenden Menschen und ihren Zugehörigen durch die Prävention und/oder Linderung dieses Schmerzes auf allen Ebenen. Der Beitrag erläutert, wie eine kultursensible Begleitung gelingen kann, welchen Stellenwert Spiritualität dabei einnimmt und welchen Beitrag die Soziale Arbeit leisten kann.
Assessment of the performance of satellite rainfall products over Makkah watershed using a physically based hydrologic model
Authors: Al-Areeq Ahmed M. , Al-Zahrani Muhammad A. , Sharif Hatim O.
Published: October 2022

Makkah region is one of the most flash flood-prone areas of Saudi Arabia due to terrain characteristics and the synoptic-scale weather conditions that intensify through interaction with the local topography causing high convective short-lived rainfall events, although these conditions are quite infrequent. Most of these events last for less than two hours. This study aims to assess the performance of five satellite precipitation products over a 1725 km2 sparsely gauged, arid basin. A fully distributed, physically based hydrologic model was forced by the five satellite precipitation products, and the evaluation included the hydrographs and runoff maps predicted by the model. Moreover, the propagation of the satellite rainfall errors into runoff predictions was quantified. Large variations and significant biases were found in satellites precipitation estimates compared to the available ground rainfall measurements. The Early IMERG product showed the best agreement with the reported total rainfall accumulations followed by Late IMERG while the other products significantly underestimated precipitation accumulations. Comparison with estimated runoff peaks showed that the Early IMERG product has the lowest errors in runoff peaks. Therefore, the hydrographs produced by the Early IMERG product were used as a reference to quantify the propagation of satellite precipitation errors into runoff predictions over the Makkah watershed. The results clearly indicated that both systematic and random rainfall errors were significantly amplified in runoff predictions.
Why hibernate? Predator avoidance in the edible dormouse
Authors: Ruf Thomas , Bieber Claudia
Published: October 2022

We address the question of ultimate selective advantages of hibernation. Biologists generally seem to accept the notion that multiday torpor is primarily a response to adverse environmental conditions, namely cold climate and low food abundance. We closely examine hibernation, and its summer equivalent estivation, in the edible dormouse, Glis glis. We conclude that in this species, hibernation is not primarily driven by poor conditions. Dormice enter torpor with fat reserves in years that are unfavourable for reproduction but provide ample food supply for animals to sustain themselves and even gain body energy reserves. While staying in hibernacula below ground, hibernators have much higher chances of survival than during the active season. We think that dormice enter prolonged torpor predominantly to avoid predation, mainly nocturnal owls. Because estivation in summer is immediately followed by hibernation, this strategy requires a good body condition in terms of fat reserves. As dormice age, they encounter fewer occasions to reproduce when calorie-rich seeds are available late in the year, and phase advance the hibernation season. By early emergence from hibernation, the best territories can be occupied and the number of mates maximised. However, this advantage comes at the cost of increased predation pressure that is maximal in spring. We argue the predator avoidance is generally one of the primary reasons for hibernation, as increased perceived predation pressure leads to an enhanced torpor use. The edible dormouse may be just an example where this behaviour becomes most obvious, on the population level and across large areas.
Climate-smart agriculture: Greenhouse gas mitigation in climate-smart villages of Ghana
Authors: Anuga Samuel Weniga , Fosu-Mensah Benedicta Yayra , Nukpezah Daniel , Ahenkan Albert , Gordon Christopher , Silvanus Baye Richmond
Published: October 2022

Climate-smart agriculture (CSA) is an approach that helps guide actions to transform agri-food systems towards green and climate-resilient practices and it remains prominent in food systems transformation in the light of increasing climate change impacts. Unfortunately, the quantification of the greenhouse gas (GHG) mitigation potential of CSA approaches is currently limited. Using the Cool Farm Tool (CFT), this paper quantifies the GHG mitigation of CSA based on farm-level experimental data. Individual interviews and focus group discussions were also conducted to identify farmers’ choices and willingness to adopt CSA practices. The study compared the GHG emission mitigation of CSA practices for two scenarios (baseline and mitigation). The study found that organic fertilizer input, residue incorporation, no-inorganic fertilizer and no-pesticide input reduced GHG emission intensity of sorghum (to 93.2 ± 25 kg CO2e GHG kg− 1 sorghum), rice (79.2 ± 22 kg CO2e GHG kg− 1 rice) and groundnut (69.7 ± 20 kg CO2e GHG kg− 1 groundnut) compared to the baseline. Lower GHG emission intensity was achieved with higher crop yield under CSA interventions. The study recommends that CSA promoters such as the Consultative Group for International Agriculture Research (CGIAR), Food and Agriculture Organization (FAO) and the World Bank focus on crop-specific CSA practices for higher GHG mitigation. CSA promoters such as the CGIAR, FAO and the World Bank should embrace participatory processes such as farmer schools to increase CSA uptake.
Treating a genre as a database: a digital research methodology for studying Chinese local gazetteers
Authors: Chen Shih-Pei , Yeh Calvin , Wang Sean , Che Qun
Published: October 2022

As digital humanities research relies on the digitization of sources, many of its applications are based on access to data on a huge scale that makes quantitative analyses and distant reading (or a birds-eye view) possible. Based on this assumption, we show how the genre of Chinese local gazetteers, with its volume, consistent structures, and broad geographic and temporal range, provides an ideal case to benefit from the digital approach. This paper introduces the Local Gazetteers Research Tools (LoGaRT), a suite of research tools designed for studying Chinese local gazetteers based on the philosophy that any comprehensive genre, such as Chinese local gazetteers, when accompanied with tools that aim to bring a collective lens to the genre, can greatly enrich the ways that scholars approach it and can transform the genre into a research infrastructure that enables new types of research. We report on how LoGaRT opens up new perspectives for researching Chinese history by showing case studies and the scholarly breakthroughs made by our research group. With this paper we hope to provide one possible answer to the question of how digital methods can contribute to humanities research. Even though LoGaRT is developed for a specific Chinese genre, we argue that the proposed research methodology and the corresponding user workflow and tools developed in our software can be applied to other genres or collections of sources when certain criteria are met.
The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation
Authors: Liao Xuezhu , Ye Yuanjun , Zhang Xiaoni , Peng Dan , Hou Mengmeng , Fu Gaofei , Tan Jianjun , Zhao Jianli , Jiang Rihong , Xu Yechun , Liu Jinmei , Yang Jinliang , Liu Wusheng , Tembrock Luke R. , Zhu Genfa , Wu Zhiqiang
Published: October 2022

Compared with most flowers where the showy part comprises specialized leaves (petals) directly subtending the reproductive structures, most Zingiberaceae species produce showy “flowers” through modifications of leaves (bracts) subtending the true flowers throughout an inflorescence. Curcuma alismatifolia, belonging to the Zingiberaceae family, a plant species originating from Southeast Asia, has become increasingly popular in the flower market worldwide because of its varied and esthetically pleasing bracts produced in different cultivars. Here, we present the chromosome-scale genome assembly of C. alismatifolia “Chiang Mai Pink” and explore the underlying mechanisms of bract pigmentation. Comparative genomic analysis revealed C. alismatifolia contains a residual signal of whole-genome duplication. Duplicated genes, including pigment-related genes, exhibit functional and structural differentiation resulting in diverse bract colors among C. alismatifolia cultivars. In addition, we identified the key genes that produce different colored bracts in C. alismatifolia, such as F3′5'H, DFR, ANS and several transcription factors for anthocyanin synthesis, as well as chlH and CAO in the chlorophyll synthesis pathway by conducting transcriptomic analysis, bulked segregant analysis using both DNA and RNA data, and population genomic analysis. This work provides data for understanding the mechanism of bract pigmentation and will accelerate breeding in developing novel cultivars with richly colored bracts in C. alismatifolia and related species. It is also important to understand the variation in the evolution of the Zingiberaceae family.
Parent-Adolescent Sexuality Communication in the African Context: A Scoping Review of the Literature
Authors: Agbeve Anthony Senanu , Fiaveh Daniel Yaw , Anto-Ocrah Martina
Published: October 2022

Introduction

Young people constitute a critical mass in Africa south of the Sahara (SSA) yet lack adequate information on sexuality education essential for their health and development.

Objectives

Guided by two sociological perspectives on socialization, that is, structural functionalism and conflict perspective, our study had 2 aims: 1) to identify and analyze studies investigating parent-adolescent sexuality communication (ie, triggers/contents) and 2) to identify and discuss barriers to sexuality-related communication between parents and adolescents.

Methods

The scoping review was conducted according to the Arksey and O'Malley framework and used PRISMA reporting guidelines for scoping reviews. We searched three databases (Scopus, PubMed, and Google Scholar) for relevant articles published in English in the last decade -2011 to 2021 and analyzed the data using a qualitative content analysis approach.

Results

A total of 1045 studies were identified. After abstract review, we identified 58 papers, and after full-text review, 16 studies were included in the final review. Aim 1a) Discussions of sexuality-related conversations were triggered by parents/caretakers due to pubertal/physical changes and adolescents’ "inapt" behaviors (eg, engaging in sex). Aim 1b) Our results showed that contents of sexuality education de-emphasized/avoided sensitive sexuality-related topics (such as condom use/contraception) that did not fit within the sociocultural norms/expectations, characterized by threats, cautions, and wrought with moralistic and religious views that evaded practical information regarding sex, contraception, and other critical sexual information. Aim 2: Two themes emerged as barriers that impede sexuality-related discussions, including whose responsibility it is to discuss sexuality-issues with adolescents and the gender differences/discordance of parent-adolescent dyads.

Conclusion

Sexuality education for adolescents in SSA is not comprehensive due to structured power relations. Thus, parent-adolescent sexuality communication falls short of the value of sexuality education for young people for whom accurate and complete sexual health information is critical for making informed decisions as they emerge into adulthood.
Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review
Authors: Hamzehnejadi Mohammadsadegh , Tavakoli Marziye Ranjbar , Homayouni Fatemeh , Jahani Zahra , Rezaei Masoud , Langarizadeh Mohammad Amin , Forootanfar Hamid
Published: October 2022

Introduction

Erectile dysfunction (ED) is a substantial cause of dissatisfaction among many men. This discontentment has led to the emergence of various drug treatment options for this problem.

Objectives

Unfortunately, due to various interactions, contraindications, and side effects, systemic therapies such as phosphodiesterase-5 inhibitors (including sildenafil, tadalafil, vardenafil, avanafil, etc.) are not welcomed in many patients. These problems have led researchers to look for other ways to reduce these complications.

Methods

This article holistically reviews the efficacy of topical prostaglandins and their role in treating ED. We sought to provide a comprehensive overview of recent findings on the current topic by using the extensive literature search to identify the latest scientific reports on the topic.

Results

In this regard, topical and transdermal treatments can be suitable alternatives. In diverse studies, prostaglandins, remarkably PGE1 (also known as alprostadil), have been suggested to be an acceptable candidate for topical treatment.

Conclusion

Numerous formulations of PGE1 have been used to treat patients so far. Still, in general, with the evolution of classical formulation methods toward modern techniques (such as using nanocarriers and skin permeability enhancers), the probability of treatment success also increases.
Civil War and the Collapse of the Social Bond
Authors: Lowrie Michèle , Vinken Barbara
Published: October 2022

Can civil war ever be overcome? Can a better order come into being? This book explores how the Roman civil wars of the first century BCE laid the template for addressing perennially urgent questions. The Roman Republic's collapse and Augustus' new Empire have remained ideological battlegrounds to this day. Integrative and disintegrative readings begun in antiquity (Vergil and Lucan) have left their mark on answers given by Christians (Augustine), secular republicans (Victor Hugo), and disillusioned satirists (Michel Houellebecq) alike. France's self-understanding as a new Rome – republican during the Revolution, imperial under successive Napoleons – makes it a special case in the Roman tradition. The same story returns repeatedly. A golden age of restoration glimmers on the horizon, but comes in the guise of a decadent, oriental empire that reintroduces and exposes everything already wrong under the defunct republic. Central to the price of social order is patriarchy's need to subjugate women.
Plants, Politics and Empire in Ancient Rome
Authors: Marzano Annalisa
Published: October 2022

The book investigates the cultural and political dimension of Roman arboriculture and the associated movement of plants from one corner of the empire to the other. It uses the convergent perspectives offered by textual and archaeological sources to sketch a picture of large-scale arboriculture as a phenomenon primarily driven by elite activity and imperialism. Arboriculture had a clear cultural role in the Roman world: it was used to construct the public persona of many elite Romans, with the introduction of new plants from far away regions or the development of new cultivars contributing to the elite competitive display. Exotic plants from conquered regions were also displayed as trophies in military triumphs, making plants an element of the language of imperialism. Annalisa Marzano argues that the Augustan era was a key moment for the development of arboriculture and identifies colonists and soldiers as important agents contributing to plant dispersal and diversity.
Textbook of Clinical Management of Club Drugs and Novel Psychoactive Substances
Authors: Abdulrahim Dima , Bowden-Jones Owen
Published: October 2022

There are global concerns about the proliferation and misuse of club drugs and novel psychoactive substances, yet we know little about their harms and research on clinical management and treatment remains limited. This book fills the knowledge gap by providing a detailed overview of the research evidence available to date. The book provides a framework that allows readers to understand this large number of new drugs, using classifications based on primary psychoactive effect. Within this framework, the book provides detailed reviews of the more commonly used drugs. Each chapter explores pharmacology, patterns and mode of use, acute and chronic harms, and clinical interventions supported by research evidence. An invaluable resource for clinical staff, this book will support clinicians working in the emergency department, substance misuse and addiction services, mental health services, primary care, sexual health services and more. It will also be of interest to academics and those developing drug policy.
Certification considerations for the configuration of a hydrogen-fuelled aeroplane
Authors: Spencer R.
Published: October 2022

Replacing kerosene with hydrogen as a fuel for propelling aeroplanes will undoubtably have ramifications for the existing certification basis and the necessary means of compliance. What this paper attempts to do is explain how a future hydrogen-powered aeroplane could be certified and how this will influence the aircraft’s design. Emphasis has been placed on the safety of hydrogen with regards flammability, ignition energy, cryogenic states and crashworthiness. The influence of certification on a future hydrogen-fuelled aeroplane’s configuration has been established. Lessons learnt from rockets are limited in scope. Consideration of hydrogen’s cryogenic and ambient temperature properties has established some fundamental safety principles. Fuel system crashworthiness influence on certification has been examined. An explosion prevention certification scheme has been developed. It is proposed to exclude oxygen from the fuel system and avoid accumulation of leaked or permeated hydrogen from adjacent zones. Three generic hydrogen-fuelled configurations have been considered for certification: adapting conventional airliner design, hydrogen-electric (fuel cell) propulsion and an unconventional approach. Hydrogen as a safe gas turbine fuel has been examined in technical and environmental terms. Further experimental work to close knowledge gaps in the aviation use of hydrogen has been suggested. In conclusion the necessary changes to the certification basis are outlined. Comments as to what the configuration of a future hydrogen-fuelled aeroplane might look like are provided. These observations are based on analysis of hydrogen’s properties, the existing certification basis, knowledge gaps, and what Special Conditions and Acceptable Means of Compliance might emerge in a future design Type Certification.
Measuring the processes of interdisciplinary team collaboration: Creating valid measures using a many-facet Rasch model approach
Authors: Wang Jue , Ahn Soyeon , Morgan Susan E.
Published: October 2022

Introduction:

The science of team science (SciTS) is an emerging research area that studies the processes and outcomes of team-based research. A well-established conceptual framework and appropriate methodology for examining the effectiveness of team science are critically important for promoting and advancing collaborative and interdisciplinary research. Although many instruments have been developed and used in the SciTS field, psychometric evidence has not been routinely assessed or reported for these scales. In addition, commonly used psychometric methods were mainly limited to internal consistency and factor analysis. To fill the gaps, this study introduces a framework based on Rasch measurement theory for creating and evaluating measures for team sciences.

Methods:

We illustrate the application of Rasch measurement theory through the creation of valid measures to evaluate the processes of interdisciplinary scientific teams. Data were collected from 16 interdisciplinary teams through a university-wide initiative for promoting interdisciplinary team collaboration. Psychometric evidence based on a many-facet Rasch model was obtained for assessing the quality of the measures.

Results:

The interdisciplinary teams differed in their clarity measures. Significant differences were also found between gender groups, racial groups, and academic ranks. We reported the reliability of measures and identified items that do not fit the model and may present potential threat to validity and fairness of SciTS measures.

Conclusion:

This study shows the great potential of using Rasch measurement theory for developing and evaluating SciTS measures. Applying Rasch measurement theory produces objective measures that are comparable across individuals, interdisciplinary teams, institutions, time, and various demographic groups.
Attenuation of turbulence in a periodic cube by finite-size spherical solid particles
Authors: Oka Sunao , Goto Susumu
Published: October 2022

To investigate the attenuation of turbulence in a periodic cube due to the addition of spherical solid particles, we conduct direct numerical simulations using an immersed boundary method with resolving flow around each particle. Numerical results with systematically changing particle diameters and Stokes numbers for a fixed volume fraction

$\varLambda$

show that the additional energy dissipation rate in the wake of particles determines the degree of the attenuation of turbulent kinetic energy. On the basis of this observation, we propose formulae describing the condition and degree of the attenuation of turbulence intensity. We conclude that particles with size proportional to

$\lambda /\sqrt {\gamma }$

, where

$\lambda$

and

$\gamma$

are the Taylor length and the mass density ratio between particles and fluid, most significantly reduce the intensity of developed turbulence under the condition that

$\gamma$

and

$\varLambda$

are fixed.
Religious Freedom and the Ethos of Democracy in Ernst-Wolfgang Böckenförde -
Discussed: Religion, Law, and Democracy: Selected Writings. By Ernst-Wolfgang Böckenförde. Edited by Mirjam Künkler and Tine Stein. Translated by Thomas Dunlap. Oxford: Oxford University Press, 2020. Pp. 480. $65.00 (cloth); Oxford Scholarship Online by subscription (digital). ISBN: 9780198818632. DOI: https://doi.org/10.1093/oso/9780198818632.001.0001.
Authors: Nicoletti Michele
Published: October 2022

According to Böckenförde’s interpretation in his famous essay “The Rise of the State as a Process of Secularization” (1967), in the formation of modern statehood religious freedom and, more generally, freedom of conscience played a central role. It was “for love of such freedom” that the modern state set inviolable limits on the exercise of its own coercive force vis-à-vis citizens relying on its protection. Nobody may be forced through the coercive tools of political power to hold true something that they do not believe. This dynamic of freedom is further taken up in Böckenförde’s analysis of church history and theological traditions, as this essay demonstrates. The conception of religious freedom as a right of the human person, contained in the Second Vatican Council declaration Dignitatis Humanae, is a real “Copernican turn.” It represents a true revolution in Catholic interpretation of democracy, public ethos, and natural law, which aims at reconciling modern freedom, democracy, and religion through a revised doctrine of the common good.
Maturing pharmacogenomic factors deliver improvements and cost efficiencies
Authors: Jarvis Joseph P. , Megill Scott E. , Silvester Peter , Shaman Jeffrey A.
Published: October 2022

An ever-expanding annotation of the human genome sequence continues to promise a new era of precision medicine. Advances in knowledge management and the ability to leverage genetic information to make clinically relevant, predictive, diagnostic, and targeted therapeutic choices offer the ability to improve patient outcomes and reduce the overall cost of healthcare. However, numerous barriers have resulted in a modest start to the clinical use of genetics at scale. Examples of successful deployments include oncologic disease treatment with targeted prescribing; however, even in these cases, genome-informed decision-making has yet to achieve standard of care in most major healthcare systems. In the last two decades, advances in genetic testing, therapeutic coverage, and clinical decision support have resulted in early-stage adoption of pharmacogenomics – the use of genetic information to routinely determine the safety and efficacy profile of specific medications for individuals. Here, through their complicated histories, we review the current state of pharmacogenomic testing technologies, the information tools that can unlock clinical utility, and value-driving implementation strategies that represent the future of pharmacogenomics-enabled healthcare decision-making. We conclude with real-world economic and clinical outcomes from a full-scale deployment and ultimately provide insight into potential tipping points for global adoption, including recent lessons from the rapid scale-up of high-volume test delivery during the global SARS-CoV2 epidemic.
ZAREMBA, SALEM AND THE FRACTAL NATURE OF GHOST DISTRIBUTIONS
Authors: COONS MICHAEL , EVANS JAMES , GROTH ZACHARY , MAÑIBO NEIL
Published: October 2022

Motivated by near-identical graphs of two increasing continuous functions—one related to Zaremba’s conjecture and the other due to Salem—we provide an explicit connection between fractals and regular sequences by showing that the graphs of ghost distributions, the distribution functions of measures associated to regular sequences, are sections of self-affine sets. Additionally, we provide a sufficient condition for such measures to be purely singular continuous. As a corollary, and analogous to Salem’s strictly increasing singular continuous function, we show that the ghost distributions of the Zaremba sequences are singular continuous.
ON MINIMAL RESTRICTED ASYMPTOTIC BASES
Authors: SHANG LINBO , LING DENGRONG , TANG MIN
Published: October 2022

Let
$h \geq 2$
be a positive integer. We introduce the concept of minimal restricted asymptotic bases and obtain some examples of minimal restricted asymptotic bases of order h.
HAS NO NONTRIVIAL IDEMPOTENTS
Authors: LIU YIFAN , ZHANG JIANGUO
Published: October 2022

We show that there is no nontrivial idempotent in the reduced group
$\ell ^p$
-operator algebra
$B^p_r(F_n)$
of the free group
$F_n$
on n generators for each positive integer n.
Exploiting tools for manipulating insect diapause
Authors: Denlinger David L.
Published: October 2022

Tools that could be used to subvert the insect diapause response offer potential for insect pest management as well as for the experimental manipulation of insects and the facilitation of mass rearing procedures. In some cases, it is desirable to break diapause on demand and in other cases, it may be attractive to exploit diapause for long-term storage of biocontrol agents or valuable experimental lines. This review highlights some of the diapause disruptors reported in the literature, as well as chemical and physical manipulations that can be used to extend diapause or even induce diapause in an insect not programmed for diapause. The insect hormones are quite effective agents for breaking diapause and in some cases for extending the duration of diapause, but a collection of other chemical agents can also act as potent diapause disruptors, e.g. organic solvents, weak acids and bases, carbon dioxide, imidazole compounds, LSD, deuterium oxide, DMSO, ouabain, cholera toxin, cyclic GMP, heavy metals, and hydrogen peroxide. Physical manipulations such as artificial light at night, anoxia, shaking and heat shock are also known diapause disruptors. Some of these documented manipulations prevent diapause, others terminate diapause immediately, others alter the duration of diapause, and a few compounds can induce a diapause-like state in insects that are not programmed for diapause. The diversity of tools noted in the literature offers promise for the development of new tools or manipulations that possibly could be used to disrupt diapause or manage diapause in controlled laboratory experiments and in mass-rearing facilities.
Depositional and thermal history of a continental, coal-bearing Middle Jurassic succession from Iran: Hojedk Formation, northern Tabas Block
Authors: Salehi Mohammad Ali , Wilmsen Markus , Zamanian Ehsan , Baniasad Alireza , Heubeck Christoph
Published: October 2022

During the early Bajocian, a conspicuous coal-bearing siliciclastic succession was deposited in the northern Tabas Bock, which is important for understanding the regional geodynamics of the Central-East Iranian Microcontinent (CEIM) as well as for the Jurassic coal genesis in this part of Laurasia. Sedimentary facies analysis in a well-exposed section of the lower Bajocian Hojedk Formation (Kalshaneh area, northern Tabas Block) led to the recognition of ten characteristic sedimentary facies and three facies associations, representing channels with point bars and floodplains of a Bajocian meandering river system. Modal analysis indicates that the mature quartz arenites and quartzo-lithic sandstones of the Hojedk Formation originated from the erosion and recycling of older, supracrustal sedimentary rocks on the Yazd Block to the west. The coal petrography and maturity show an advanced maturation stage, whereas the great thickness of these continental strata points to a pronounced extension-related subsidence in the northern Tabas Block. The rapid rate of differential subsidence can be explained by accelerated normal block-faulting in the back-arc extensional basin of the CEIM, facing the Neotethys to the south. Compared to the thick Jurassic, the post-Jurassic strata are relatively thin and played a limited role in the thermal history of the coal in the northern Tabas Block. A relatively high geothermal gradient in the tectonically highly mobile area of the northern Tabas Block and/or heating by regionally widespread Palaeogene intrusions were most probably the key drivers of the thermal maturation of the Middle Jurassic coals.
The Ethno-Necrocratic State: Mamillah and the Afterlives of Ethnocracy in Israel
Authors: Belli Meriam N.
Published: October 2022

Using the unique and historic Islamic cemetery of Mamillah in Jerusalem as a primary example, this essay discusses the ethno-necrocratic order that led to the 2008 Israeli High Court of Justice's codification of the supremacy of Jewish bodies and afterlives over non-Jewish ones, on the basis of advancing Israel's values. Hundreds of Palestinian burial grounds, starting with village cemeteries, have been destroyed since 1948. Indeed, funerary sites have testified to the omnipresence and millenarian existence of a population that the state has sought to erase from memory. In a few decades, the deathscape was radically altered, in cities as in the countryside. Although real estate corruption plagues Israeli politics, land use planning and real estate capitalism are inseparable from the ethno-racial politics of exclusion, which affect both the dead and the living.
The Real Effects of Equity Markets on Innovation
Authors: Mace Chris
Published: October 2022

In theory, financial markets promote innovation by selectively allocating capital to high-quality projects. In this article, I show that equity markets can also inhibit innovation. In public firms, I find that short-term equity market declines cause pharmaceutical companies to abandon early-stage drug developments, irrespective of drug quality or changes in a firm’s stock price. I show that financing constraints drive this behavior, highlighting that even short-term market fluctuations can have long-term effects on pharmaceutical innovation and prevent potentially life-saving drugs from progressing to the market.
Calculation of collisionless pitch-angle scattering of runaway electrons with synchrotron radiation via high-order guiding-centre equation
Authors: Liu Shi-Jie , Wang Feng , Liu Chang , Hu Di , Wu Kai-Bang , Liu Jian , Wang Zheng-Xiong
Published: October 2022

Recently, the collisionless pitch-angle scattering for relativistic runaway electrons (REs) in toroidal geometries such as tokamaks was discovered through a full orbit simulation approach (Liu et al., Nucl. Fusion, vol. 56, 2016, p. 064002), and it was then theoretically investigated that a new expression for the magnetic moment, including the second-order corrections, could essentially reproduce the so-called collisionless pitch-angle scattering process (Liu et al., Nucl. Fusion, vol. 58, 2018, p. 106018). In this paper, with synchrotron radiation, extensive numerical verification of the validity of the high-order guiding-centre theory is given for simulations involving REs by incorporating such an expression for the magnetic moment into our particle tracing code. A high-order guiding-centre simulation approach with synchrotron radiation (HGSA) is applied. Synchrotron radiation plays an essential role in the life cycle of REs. The energy of REs first increases and then becomes saturated until the electric field acceleration is balanced by the radiation dissipation. Unfortunately, the process cannot be simulated accurately with the standard guiding-centre model, i.e. the first-order guiding-centre model. Remarkably, it is found that the HGSA can effectively produce the fundamental process of REs. Since the time scale of the energy saturation of REs is close to seconds, the computational cost becomes significant. In order to save costs, it is necessary to estimate the time of energy saturation. An analytical estimate is derived for the time it takes for synchrotron drag to balance an accelerating electric field and the provided formula has been numerically verified. Test calculations reveal that HGSA is favourable for exploiting the dynamics of REs in tokamak plasmas.
‘Purification’ and ‘Hybridization’: (Re)construction and Reception of Theatrical Nationality in Western Tours of the Mei Lanfang and Tsutsui Troupes in 1930
Authors: GAO YANG
Published: October 2022

The Western tours of the Mei Lanfang and Tsutsui troupes in 1930 illustrated how to (re)construct the theatrical nationality of China and Japan through the manifestation and manipulation of the performance of Peking opera and kabuki. Through the ‘purification’ of Peking opera's stage presentation system, the Mei Lanfang troupe forged a ‘pure’ theatrical Chineseness that boosted the Americans’ fascination with the ‘(a)historicality’ of Chinese theatrical tradition. By presenting Westerners with a ‘hybridized’ kabuki, which embodied a ‘historically authentic’ theatrical Japaneseness, the Tsutsui troupe deconstructed Westerners’ psychological expectations of a culturally imagined ‘pure’ and ‘classical’ Japanese theatre. As two sides of the same coin, the two troupes’ (re)construction of theatrical Chineseness and Japaneseness together challenged the West's essentialist views of cultural ‘Others’, which forcibly endowed Eastern theatre with a pure and unchanged ‘otherness’.
The moderating role of adrenocortical reactivity in the associations between interparental conflict, emotional reactivity, and school adjustment
Authors: Pearson Joanna K. , Davies Patrick T. , Sturge-Apple Melissa L.
Published: October 2022

This study tested whether the associations between interparental conflict, children’s emotional reactivity, and school adjustment were moderated by children’s cortisol reactivity in a sample of young children (N = 243; mean age = 4.6 years at Wave 1; 56% female, 44% male) and their parents. Using a longitudinal, autoregressive design, observational assessments of children’s emotional reactivity at Wave 2 mediated the relationship between an observational measure of Wave 1 conflict between parents and teacher’s report of children’s school adjustment at Wave 3. However, children’s cortisol reactivity to parent conflict at Wave 1 moderated the first link, such that emotional reactivity operated as a mediator for children with heightened cortisol reactivity but not children with low cortisol reactivity. Moderation was expressed in a “for better” or “for worse” form hypothesized by biological sensitivity to context theory. Thus, children with high cortisol reactivity experienced greater emotional reactivity than their peers when faced with more destructive conflict but also lower emotional reactivity when exposed to more constructive interparental conflict. Results are discussed as to how they advance emotional security and biological sensitivity to context theories.
Migrating gradual types
Authors: CAMPORA JOHN PETER , CHEN SHENG , ERWIG MARTIN , WALKINGSHAW ERIC
Published: October 2022

Gradual typing allows programs to enjoy the benefits of both static typing and dynamic typing. While it is often desirable to migrate a program from more dynamically typed to more statically typed or vice versa, gradual typing itself does not provide a way to facilitate this migration. This places the burden on programmers who have to manually add or remove type annotations. Besides the general challenge of adding type annotations to dynamically typed code, there are subtle interactions between these annotations in gradually typed code that exacerbate the situation. For example, to migrate a program to be as static as possible, in general, all possible combinations of adding or removing type annotations from parameters must be tried out and compared. In this paper, we address this problem by developingmigrational typing, which efficiently types all possible ways of replacing dynamic types with fully static types for a gradually typed program. The typing result supports automatically migrating a program to be as static as possible or introducing the least number of dynamic types necessary to remove a type error. The approach can be extended to support user-defined criteria about which annotations to modify. We have implemented migrational typing and evaluated it on large programs. The results show that migrational typing scales linearly with the size of the program and takes only 2–4 times longer than plain gradual typing.