bluuebunny/crossref_metadata_2025 huggingface dataset:
Grand Challenges in Materials Science: A Special Issue
Authors: Uskoković Vuk
Published: September 2023

Materials science has and will continue to be a science at a crossroads [...]
Distance Correlation Market Graph: The Case of S&P500 Stocks
Authors: Ugwu Samuel , Miasnikof Pierre , Lawryshyn Yuri
Published: September 2023

This study investigates the use of a novel market graph model for equity markets. Our graph model is built on distance correlation instead of the traditional Pearson correlation. We apply it to the study of S&P500 stocks from January 2015 to December 2022. We also compare our market graphs to the traditional market graphs in the literature, those built using Pearson correlation. To further the comparison, we also build graphs using Spearman rank correlation. Our comparisons reveal that non-linear relationships in stock returns are not captured by either Pearson correlation or Spearman rank correlation. We observe that distance correlation is a robust measure for detecting complex relationships in S&P500 stock returns. Networks built on distance correlation networks, are shown to be more responsive to market conditions during turbulent periods such as the COVID crash period.
Improved Power Series Solution of Transversely Loaded Hollow Annular Membranes: Simultaneous Modification of Out-of-Plane Equilibrium Equation and Radial Geometric Equation
Authors: He Xiao-Ting , Li Fei-Yan , Sun Jun-Yi
Published: September 2023

The ability to accurately predict the shape of a transversely loaded hollow annular membrane is essential to the design of bending-free hollow annular shells of revolution, which requires a further improvement in the hollow annular membrane solution to meet the needs of this accurate prediction. In this paper, the large deflection problem of a transversely loaded hollow annular membrane is reformulated by simultaneously modifying the out-of-plane equilibrium equation and radial geometric equation, and a newer and more refined power series solution is derived. The reason why the classical radial geometry equation induces errors is revealed. The convergence and asymptotic behavior of the power series solution obtained is analyzed numerically. The newly derived solution is compared with the two previously derived solutions graphically, showing that the newly derived solution performs basically as well as expected. In addition, the anticipated use of the hollow and not-hollow annular membrane solutions for the design application of bending-free annular shells of revolution is discussed.
The Fuzzy Differential Transform Method for the Solution of the System of Fuzzy Integro-Differential Equations Arising in Biological Model
Authors: Routaray Mitali , Sahu Prakash Kumar , Chalishajar Dimplekumar Navinchandra
Published: September 2023

This article deals with the implementation of fuzzy differential transform method for solving a system of nonlinear fuzzy integro-differential equations. This system appears in a model of biological species living together. Though the differential transform method is an iterative method, the current approach reduces this model to a set of nonlinear algebraic equations due to its delay terms. The basic definitions and theorems are first presented. The applicability and accuracy of the current methodologies have been demonstrated through the discussion of a few exemplary situations.
The Recurrence Coefficients of Orthogonal Polynomials with a Weight Interpolating between the Laguerre Weight and the Exponential Cubic Weight
Authors: Min Chao , Fang Pixin
Published: September 2023

In this paper, we consider the orthogonal polynomials with respect to the weight w(x)=w(x;s):=xλe−N[x+s(x3−x)],x∈R+, where λ>0, N>0 and 0≤s≤1. By using the ladder operator approach, we obtain a pair of second-order nonlinear difference equations and a pair of differential–difference equations satisfied by the recurrence coefficients αn(s) and βn(s). We also establish the relation between the associated Hankel determinant and the recurrence coefficients. From Dyson’s Coulomb fluid approach, we prove that the recurrence coefficients converge and the limits are derived explicitly when q:=n/N is fixed as n→∞.
The Effects of Mindfulness on Glycemic Control in People with Diabetes: An Overview of Systematic Reviews and Meta-Analyses
Authors: Hamasaki Hidetaka
Published: September 2023

Background: Previous research has demonstrated the effectiveness of mindfulness interventions in improving glycemic control. By enhancing attention control, emotion regulation, and self-awareness, mindfulness shows promise in managing the lifestyle factors associated with cardiovascular disease risk. However, the impact of mindfulness on glycemic control in people with diabetes remains unclear. This overview aims to summarize the current evidence of the impact of mindfulness interventions on glycemic control in people with diabetes and propose suggestions for future research. Methods: The author searched electronic databases (PubMed/MEDLINE, Embase, and Cochrane Library) to identify relevant systematic reviews and meta-analyses. The current evidence regarding the effects of mindfulness on glycemic control in people with diabetes was summarized. Results: This review evaluated a total of five systematic reviews and meta-analyses of randomized controlled trials (RCTs). Mindfulness interventions show potential for improving glycemic control as measured by hemoglobin A1c (HbA1c) levels, as well as reducing stress, depression, and anxiety in people with diabetes. Four out of five systematic reviews and meta-analyses reported a significant reduction in HbA1c levels by approximately 0.3%. However, the available studies lacked adequate description of key characteristics of study subjects, such as body mass index, medication, and disease conditions, which are essential for assessing the impact of mindfulness on glycemic control. Moreover, there was significant heterogeneity in the intervention methods employed across the included RCTs. Conclusions: Mindfulness interventions are effective in improving glycemic control in people with type 2 diabetes. However, the overall quality of the reviewed studies raises uncertainty regarding the effectiveness of mindfulness as a treatment for people with diabetes. Further research is necessary to elucidate the biological effects of mindfulness on physiological, neurological, and endocrinological functions in humans.
Fabrication of Polycrystalline Zeolitic Imidazolate Framework Membranes by a Vapor-Phase Seeding Method
Authors: Qiang Zhiqin , Yi Zihao , Wang Jun-Wei , Khandge Rahul Sampat , Ma Xiaoli
Published: September 2023

The reliable fabrication of polycrystalline zeolitic imidazolate framework (ZIF) membranes continues to pose challenges for their industrial applications. Here, we present a vapor-phase seeding approach that integrates atomic layer deposition (ALD) with ligand vapor treatment to synthesize ZIF membranes with high propylene/propane separation performance. This method began with depositing a ZnO coating onto the support surface via ALD. The support underwent treatment with 2-methylimidazole vapor to transform ZnO to ZIF-8, forming the seed layer. Subsequent secondary growth was employed at near-room temperature, allowing the seeds to grow into a continuous membrane. ZIF-8 membranes made on macroporous ceramic support by this method consistently demonstrated propylene permeances above 1 × 10−8 mol Pa−1 m−2 s−1 and a propylene/propane separation factor exceeding 50. Moreover, we demonstrated the effectiveness of the vapor-phase seeding method in producing the ZIF-67 membrane.
Orientation Dependence of B19’-Martensite Reorientation Stress and Yield Stress in TiNi Single Crystals
Authors: Panchenko Elena Y. , Eftifeeva Anna S. , Fatkullin Ilya D. , Tagiltsev Anton I. , Surikov Nikita Y. , Zherdeva Maria V. , Timofeeva Ekaterina E. , Chumlyakov Yuriy I.
Published: September 2023

This paper deals with the effect of crystal orientation on the B19’-martensite reorientation stress and yield stress in compression in TiNi single crystals with different Ni contents varying from 50.4 to 51.2 at.%. It was experimentally shown that the martensite yield stress appears to be higher for the [111]B2-oriented single crystals than for the [001]B2-oriented single crystals regardless of Ni content. The difference between martensite yield stress for the two investigated orientations increases with the growth of Ni content. The maximum difference between martensite yield stress σcrM for two investigated orientations is 996 MPa at Ni content of 51.2 at.% (σcrM = 1023 MPa for the [001]B2-orientation and σcrM = 2019 MPa for the [111]B2-orientation). As a result of comparison with the B2-austenite yield stress, it was found that this is not an ordinary case. The [001]B2 orientation is a high-strength in B2-austenite and a low-strength in B19’-martensite. It was experimentally shown that the B19’-martensite reorientation stresses weakly depend on the orientation and chemical composition compared with the martensite yield stress. The reasons for the orientation dependence of the martensite yield stress in compression and the deformation mechanisms of B19’-martensite are discussed.
Point-of-Care Devices for Viral Detection: COVID-19 Pandemic and Beyond
Authors: Yadav Sumit K. , Verma Damini , Yadav Ujala , Kalkal Ashish , Priyadarshini Nivedita , Kumar Ashutosh , Mahato Kuldeep
Published: September 2023

The pandemic of COVID-19 and its widespread transmission have made us realize the importance of early, quick diagnostic tests for facilitating effective cure and management. The primary obstacles encountered were accurately distinguishing COVID-19 from other illnesses including the flu, common cold, etc. While the polymerase chain reaction technique is a robust technique for the determination of SARS-CoV-2 in patients of COVID-19, there arises a high demand for affordable, quick, user-friendly, and precise point-of-care (POC) diagnostic in therapeutic settings. The necessity for available tests with rapid outcomes spurred the advancement of POC tests that are characterized by speed, automation, and high precision and accuracy. Paper-based POC devices have gained increasing interest in recent years because of rapid, low-cost detection without requiring external instruments. At present, microfluidic paper-based analysis devices have garnered public attention and accelerated the development of such POCT for efficient multistep assays. In the current review, our focus will be on the fabrication of detection modules for SARS-CoV-2. Here, we have included a discussion on various strategies for the detection of viral moieties. The compilation of these strategies would offer comprehensive insight into the detection of the causative agent preparedness for future pandemics. We also provide a descriptive outline for paper-based diagnostic platforms, involving the determination mechanisms, as well as a commercial kit for COVID-19 as well as their outlook.
Carbon-Based Enzyme Mimetics for Electrochemical Biosensing
Authors: Sánchez-Tirado Esther , Yáñez-Sedeño Paloma , Pingarrón José Manuel
Published: September 2023

Natural enzymes are used as special reagents for the preparation of electrochemical (bio)sensors due to their ability to catalyze processes, improving the selectivity of detection. However, some drawbacks, such as denaturation in harsh experimental conditions and their rapid de- gradation, as well as the high cost and difficulties in recycling them, restrict their practical applications. Nowadays, the use of artificial enzymes, mostly based on nanomaterials, mimicking the functions of natural products, has been growing. These so-called nanozymes present several advantages over natural enzymes, such as enhanced stability, low cost, easy production, and rapid activity. These outstanding features are responsible for their widespread use in areas such as catalysis, energy, imaging, sensing, or biomedicine. These materials can be divided into two main groups: metal and carbon-based nanozymes. The latter provides additional advantages compared to metal nanozymes, i.e., stable and tuneable activity and good biocompatibility, mimicking enzyme activities such as those of peroxidase, catalase, oxidase, superoxide dismutase, nuclease, or phosphatase. In this review article, we have focused on the use of carbon-based nanozymes for the preparation of electrochemical (bio)sensors. The main features of the most recent applications have been revised and illustrated with examples selected from the literature over the last four years (since 2020).
Implementation of Wavelet-Transform-Based Algorithms in an FPGA for Heart Rate and RT Interval Automatic Measurements in Real Time: Application in a Long-Term Ambulatory Electrocardiogram Monitor
Authors: García Limón José Alberto , Martínez-Suárez Frank , Alvarado-Serrano Carlos
Published: September 2023

Cardiovascular diseases are currently the leading cause of death worldwide. Thus, there is a need for non-invasive ambulatory (Holter) ECG monitors with automatic measurements of ECG intervals to evaluate electrocardiographic abnormalities of patients with cardiac diseases. This work presents the implementation of algorithms in an FPGA for beat-to-beat heart rate and RT interval measurements based on the continuous wavelet transform (CWT) with splines for a prototype of an ambulatory ECG monitor of three leads. The prototype’s main elements are an analog–digital converter ADS1294, an FPGA of Xilinx XC7A35T-ICPG236C of the Artix-7 family of low consumption, immersed in a low-scale Cmod-A7 development card integration, an LCD display and a micro-SD memory of 16 Gb. A main state machine initializes and manages the simultaneous acquisition of three leads from the ADS1294 and filters the signals using a FIR filter. The algorithm based on the CWT with splines detects the QRS complex (R or S wave) and then the T-wave end using a search window. Finally, the heart rate (60/RR interval) and the RT interval (from R peak to T-wave end) are calculated for analysis of its dynamics. The micro-SD memory stores the three leads and the RR and RT intervals, and an LCD screen displays the beat-to-beat values of heart rate, RT interval and the electrode connection. The algorithm implemented on the FPGA achieved satisfactory results in detecting different morphologies of QRS complexes and T wave in real time for the analysis of heart rate and RT interval dynamics.
Carbon-Based Electrochemical (Bio)sensors for the Detection of Carbendazim: A Review
Authors: Venegas Constanza J. , Bollo Soledad , Sierra-Rosales Paulina
Published: September 2023

Carbendazim, a fungicide widely used in agriculture, has been classified as a hazardous chemical by the World Health Organization due to its environmental persistence. It is prohibited in several countries; therefore, detecting it in food and environmental samples is highly necessary. A reliable, rapid, and low-cost method uses electrochemical sensors and biosensors, especially those modified with carbon-based materials with good analytical performance. In this review, we summarize the use of carbon-based electrochemical (bio)sensors for detecting carbendazim in environmental and food matrixes, with a particular interest in the role of carbon materials. Focus on publications between 2018 and 2023 that have been describing the use of carbon nanotubes, carbon nitride, graphene, and its derivatives, and carbon-based materials as modifiers, emphasizing the analytical performance obtained, such as linear range, detection limit, selectivity, and the matrix where the detection was applied.
Design Strategies of 40 nm Split-Gate NOR Flash Memory Device for Low-Power Compute-in-Memory Applications
Authors: Yook Chan-Gi , Kim Jung Nam , Kim Yoon , Shim Wonbo
Published: September 2023

The existing von Neumann architecture for artificial intelligence (AI) computations suffers from excessive power consumption and memory bottlenecks. As an alternative, compute-in-memory (CIM) technology has been emerging. Among various CIM device candidates, split-gate NOR flash offers advantages such as a high density and low on-state current, enabling low-power operation, and benefiting from a high level of technological maturity. To achieve high energy efficiency and high accuracy in CIM inference chips, it is necessary to optimize device design by targeting low power consumption at the device level and surpassing baseline accuracy at the system level. In split-gate NOR flash, significant factors that can cause CIM inference accuracy drop are the device conductance variation, caused by floating gate charge variation, and a low on-off current ratio. Conductance variation generally has a trade-off relationship with the on-current, which greatly affects CIM dynamic power consumption. In this paper, we propose strategies for designing optimal devices by adjusting oxide thickness and other structural parameters. As a result of setting Tox,FG to 13.4 nm, TIPO to 4.6 nm and setting other parameters to optimal points, the design achieves erase on-current below 2 μA, program on-current below 10 pA, and off-current below 1 pA, while maintaining an inference accuracy of over 92%.
Molecular Mechanisms of Persistence in Protozoan Parasites
Authors: Tarannum Asfiha , Rodríguez-Almonacid Cristian Camilo , Salazar-Bravo Jorge , Karamysheva Zemfira N.
Published: September 2023

Protozoan parasites are known for their remarkable capacity to persist within the bodies of vertebrate hosts, which frequently results in prolonged infections and the recurrence of diseases. Understanding the molecular mechanisms that underlie the event of persistence is of paramount significance to develop innovative therapeutic approaches, given that these pathways still need to be thoroughly elucidated. The present article provides a comprehensive overview of the latest developments in the investigation of protozoan persistence in vertebrate hosts. The focus is primarily on the function of persisters, their formation within the host, and the specific molecular interactions between host and parasite while they persist. Additionally, we examine the metabolomic, transcriptional, and translational changes that protozoan parasites undergo during persistence within vertebrate hosts, focusing on major parasites such as Plasmodium spp., Trypanosoma spp., Leishmania spp., and Toxoplasma spp. Key findings of our study suggest that protozoan parasites deploy several molecular and physiological strategies to evade the host immune surveillance and sustain their persistence. Furthermore, some parasites undergo stage differentiation, enabling them to acclimate to varying host environments and immune challenges. More often, stressors such as drug exposure were demonstrated to impact the formation of protozoan persisters significantly. Understanding the molecular mechanisms regulating the persistence of protozoan parasites in vertebrate hosts can reinvigorate our current insights into host–parasite interactions and facilitate the development of more efficacious disease therapeutics.
Encapsulation of Hemp (Cannabis sativa L.) Essential Oils into Nanoemulsions for Potential Therapeutic Applications: Assessment of Cytotoxicological Profiles
Authors: Aguzzi Cristina , Perinelli Diego Romano , Cespi Marco , Zeppa Laura , Mazzara Eugenia , Maggi Filippo , Petrelli Riccardo , Bonacucina Giulia , Nabissi Massimo
Published: September 2023

Industrial hemp (Cannabis sativa L.), due to its bioactive compounds (terpenes and cannabinoids), has gained increasing interest in different fields, including for medical purposes. The evaluation of the safety profile of hemp essential oil (EO) and its encapsulated form (nanoemulsion, NE) is a relevant aspect for potential therapeutic applications. This study aimed to evaluate the toxicological effect of hemp EOs and NEs from cultivars Carmagnola CS and Uso 31 on three cell lines selected as models for topical and inhalant administration, by evaluating the cytotoxicity and the cytokine expression profiles. Results show that EOs and their NEs have comparable cytotoxicity, if considering the quantity of EO present in the NE. Moreover, cells treated with EOs and NEs showed, in most of the cases, lower levels of proinflammatory cytokines compared to Etoposide used as a positive control, and the basal level of inflammatory cytokines was not altered, suggesting a safety profile of hemp EOs and their NEs to support their use for medical applications.
5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens
Authors: Rogacheva Elizaveta , Kraeva Lyudmila , Lukin Alexey , Vinogradova Lyubov , Komarova Kristina , Chudinov Mikhail , Gureev Maxim , Chupakhin Evgeny
Published: September 2023

A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(1,3-oxazol-5-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c] pyridine (13g), which is superior to nitrofurantoin. These results confirmed the benefit of combining a THPP scaffold with a nitrofuran warhead. Certain structure–activity relationships were established in the course of this study which were rationalized by the induced-fit docking experiments in silico.
A Pharmacokinetic Study of Sixteen Major Bioactive Components of Jinshui-Huanxian Granules in Pulmonary Fibrosis Model and Control Rats Using Orbitrap Fusion Mass Spectrometry
Authors: Zhang Weiwei , Wan Yan , Sun Shuding , Xie Yang , Zhao Di , Li Bing , Li Jiansheng , Tian Yange , Feng Suxiang
Published: September 2023

Jinshui-Huanxian granules (JHGs), a Chinese herbal compound prescription, have shown a therapeutic effect in reducing lung tissue damage, improving the degree of pulmonary fibrosis, replenishing lungs and kidneys, relieving cough and asthma, reducing phlegm, and activating blood circulation. However, these active compounds’ pharmacokinetics and metabolic processes were unclear. This study aimed to compare the pharmacokinetics, reveal the metabolic dynamic changes, and obtain the basic pharmacokinetic parameters of 16 main bioactive compounds after intragastric administration of JHGs in control and pulmonary fibrosis (PF) model rats by using Orbitrap Fusion MS. After administration of JHGs, the rat plasma was collected at different times. Pretreating the plasma sample with methanol and internal standard (IS) solution carbamazepine (CBZ), and it was then applied to a C18 column by setting gradient elution with a mobile phase consisting of methanol 0.1% formic acid aqueous solution. Detection was performed on an electrospray ionization source (ESI), and the scanning mode was SIM. Pharmacokinetic parameters were analyzed according to the different analytes’ concentrations in plasma. The matrix effect was within the range of 79.01–110.90%, the extraction recovery rate was 80.37–102.72%, the intra-day and inter-day precision relative standard deviation (RSD) was less than 7.76%, and the stability was good, which met the requirements of biological sample testing. The method was validated (r ≥ 0.9955) and applied to compare the pharmacokinetic profiles of the control group and PF model group after intragastric administration of the JHGs. The 16 analytes exhibited different pharmacokinetic behaviors in vivo. In the pathological state of the PF model, most of the components were more favorable for metabolism and absorption, and it was more meaningful to study the pharmacokinetics. Above all, this study provided an essential reference for exploring the mechanism of action of JHGs and guided clinical medication as well.
The Effect of Organic Matter from Sewage Sludge as an Interfacial Layer on the Surface of Nano-Al and Fluoride
Authors: Gao Fan , Ma Xueqin , Tan Yi , Zhang Bo , Yang Yixing , Nie Hongqi , Xu Zhixiang
Published: September 2023

Due to its high reactivity, the nano aluminum particle (n-Al) has attracted more attention in energetic materials but is easily oxidized during processing. In order to realize sewage sludge (SS) resource and n-Al coating, the organic matter was extracted from SS, using the deep eutectic solvent method due to its strong dissolving capacity, and then the organic matter was pretreated by ball milling, which was used as an interfacial layer between n-Al and fluoride. It was found that organic matter was successfully extracted from SS. The main organic matter is proteins. The ball milling method can effectively destroy the secondary structure of proteins to release more active functional groups. During the pretreatment, the Maillard reaction broke the proteins structure to form more active low molecular weight compounds. It was confirmed that n-Al can be coated by PBSP under mild conditions to form a uniform core-shell structure. PFOA can effectively coat the n-Al@PBSP to form n-Al@PBSP/PFOA, which can enhance the combustion of n-Al. The gas phase flame temperature can notably improve to 2892 K. The reaction mechanism between n-Al and coating was analyzed. The results could help SS treatment and provide new insights for n-Al coating and SS-based organic matter recovery and utilization.
Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity
Authors: Sharma Richa , Yadav Lalit , Nasim Ali Adnan , Yadav Ravi Kant , Chen Rui Hong , Kumari Neha , Ruiqi Fan , Sharon Ashoke , Sahu Nawal Kishore , Ippagunta Sirish Kumar , Coghi Paolo , Wong Vincent Kam Wai , Chaudhary Sandeep
Published: September 2023

A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen) reaction under microwave irradiation conditions. The structure elucidation of all the synthesized spirooxindoles were done using 1H and 13C NMR and HRMS spectral analysis. The single crystal X-ray crystallographic study of compound 4l was used to assign the stereochemical arrangements of the groups around the pyrrolidine ring in spiro[pyrrolidine-2,3′-oxindoles] skeleton. The in vitro anticancer activity of spiro[pyrrolidine-2,3′-oxindoles] analogs 4a–w against human lung (A549) and liver (HepG2) cancer cell lines along with immortalized normal lung (BEAS-2B) and liver (LO2) cell lines shows promising results. Out of the 23 synthesized spiro[pyrrolidine-2,3′-oxindoles], while five compounds (4c, 4f, 4m, 4q, 4t) (IC50 = 34.99–47.92 µM; SI = 0.96–2.43) displayed significant in vitro anticancer activity against human lung (A549) cancer cell lines, six compounds (4c, 4f, 4k, 4m, 4q, 4t) (IC50 = 41.56–86.53 µM; SI = 0.49–0.99) displayed promising in vitro anticancer activity against human liver (HepG2) cancer cell lines. In the case of lung (A549) cancer cell lines, these compounds were recognized to be more efficient and selective than standard reference artemisinin (IC50 = 100 µM) and chloroquine (IC50 = 100 µM; SI: 0.03). However, none of them were found to be active as compared to artesunic acid [IC50 = 9.85 µM; SI = 0.76 against lung (A549) cancer cell line and IC50 = 4.09 µM; SI = 2.01 against liver (HepG2) cancer cell line].
Shortwave Infrared InGaAs Detectors On-Chip Integrated with Subwavelength Polarization Gratings
Authors: Huang Huijuan , Yu Yizhen , Li Xue , Sun Duo , Zhang Guixue , Li Tao , Shao Xiumei , Yang Bo
Published: September 2023

Shortwave infrared polarization imaging can increase the contrast of the target to the background to improve the detection system’s recognition ability. The division of focal plane polarization indium gallium arsenide (InGaAs) focal plane array (FPA) detector is the ideal choice due to the advantages of compact structure, real-time imaging, and high stability. However, because of the mismatch between nanostructures and photosensitive pixels as well as the crosstalk among the different polarization directions, the currently reported extinction ratio (ER) of superpixel-polarization-integrated detectors cannot meet the needs of high-quality imaging. In this paper, a 1024 × 4 InGaAs FPA detector on-chip integrated with a linear polarization grating (LPG) was realized and tested. The detector displayed good performance throughout the 0.9–1.7 um band, and the ERs at 1064 nm, 1310 nm and 1550 nm reached up to 22:1, 29:1 and 46:1, respectively. For the crosstalk investigation, the optical simulation of the grating-integrated InGaAs pixel was carried out, and the limitation of the ER was calculated. The result showed that the scattering of incident light in the InP substrate led to the crosstalk. Moreover, the deviation of the actual grating morphology from the designed structure caused a further reduction in the ER.
Potential Role for Diet in Mediating the Association of Olfactory Dysfunction and Cognitive Decline: A Nationally Representative Study
Authors: Vohra Varun , Assi Sahar , Kamath Vidyulata , Soler Zachary , Rowan Nicholas
Published: September 2023

In the context of a growing body of evidence associating olfactory dysfunction (OD) with cognitive decline, this cross-sectional study used data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) sample in order to explore the role of dietary intake in this association. Leveraging a nationally representative sample of U.S. adults aged 60 years and older, this study analyzed dietary patterns using exploratory factor analysis. OD was categorized based on the NHANES Pocket Smell Test, and cognitive function was measured with a battery of tests. Survey-weighted multivariable regressions and causal mediation analysis were used to examine the relationship between dietary patterns, OD, and cognitive function. Results indicated that a poor adherence to a diet rich in monounsaturated fats (MUFAs) and polyunsaturated fats (PUFAs) was independently associated with both cognitive and olfactory dysfunctions, after adjusting for sociodemographic and health factors. Moreover, the relationship between OD and cognitive decline was found to be partly mediated by adherence to such a diet. This study proposes a potential link between diet, olfactory function, and cognitive decline, highlighting the role of nutritional interventions in mitigating cognitive decline, particularly in individuals with olfactory impairment.
The Role of the Western Diet on Atopic Dermatitis: Our Experience and Review of the Current Literature
Authors: Ilaria Proietti , Ersilia Tolino , Nicoletta Bernardini , Federica Trovato , Andrea Vizzaccaro , Nevena Skroza , Concetta Potenza
Published: September 2023

The correlation between health and diet has always been a subject of interest in the field of dermatology and medicine in general. However, studies in the literature are still scarce, and need further investigation in the field of inflammatory skin diseases. In this paper, we report a case of a patient with atopic dermatitis whose complete recovery occurred only after combining dupilumab therapy with a Mediterranean diet regimen.
The Role of Lipids in the Regulation of Immune Responses
Authors: Garcia Chelsea , Andersen Catherine J. , Blesso Christopher N.
Published: September 2023

Lipid metabolism plays a major role in the regulation of the immune system. Exogenous (dietary and microbial-derived) and endogenous (non-microbial-derived) lipids play a direct role in regulating immune cell activation, differentiation and expansion, and inflammatory phenotypes. Understanding the complexities of lipid–immune interactions may have important implications for human health, as certain lipids or immune pathways may be beneficial in circumstances of acute infection yet detrimental in chronic inflammatory diseases. Further, there are key differences in the lipid effects between specific immune cell types and location (e.g., gut mucosal vs. systemic immune cells), suggesting that the immunomodulatory properties of lipids may be tissue-compartment-specific, although the direct effect of dietary lipids on the mucosal immune system warrants further investigation. Importantly, there is recent evidence to suggest that lipid–immune interactions are dependent on sex, metabolic status, and the gut microbiome in preclinical models. While the lipid–immune relationship has not been adequately established in/translated to humans, research is warranted to evaluate the differences in lipid–immune interactions across individuals and whether the optimization of lipid–immune interactions requires precision nutrition approaches to mitigate or manage disease. In this review, we discuss the mechanisms by which lipids regulate immune responses and the influence of dietary lipids on these processes, highlighting compelling areas for future research.
Effects of Indonesian Shortfin Eel (Anguilla bicolor) By-Product Oil Supplementation on HOMA-IR and Lipid Profile in Obese Male Wistar Rats
Authors: Megawati Ginna , Syahruddin Siti Shofiah , Tjandra Winona , Kusumawati Maya , Herawati Dewi Marhaeni Diah , Gurnida Dida Achmad , Musfiroh Ida
Published: September 2023

The prevalence of people being overweight and obese has increased globally over the past decades. The use of omega-3 fatty acids—a compound usually primarily found in fish oil—has been known to improve the metabolic profile of obese patients. As the demand for eels increases, the number of waste products from the eels increases and creates environmental problems. This study was conducted to investigate the effect of a newly discovered Indonesian Shortfin eel by-product oil supplementation on the Homeostasis Model Assessment-Estimated Insulin Resistance (HOMA-IR) and lipid profiles of obese male (Lee index ≥ 0.3) Wistar rats (Rattus norvegicus). The oil was extracted from waste products (heads). Fifteen obese rats were divided into three groups and were administered NaCl (C), commercial fish oil (CO), and Indonesian shortfin eel by-product oil (EO). All groups had statistically significant differences in total cholesterol, LDL, and triglyceride levels (p < 0.05). The CO and EO group showed a significant decrease in total cholesterol, LDL, and triglyceride after treatment. However, no significant difference was found in HDL levels and HOMA-IR. The supplementation of Indonesian shortfin eel by-product oil significantly improved lipid profile while effectively mitigating environmental challenges.
Enhancing Bioaccessibility of Plant Protein Using Probiotics: An In Vitro Study
Authors: Marttinen Maija , Anjum Mehreen , Saarinen Markku T. , Ahonen Ilmari , Lehtinen Markus J. , Nurminen Päivi , Laitila Arja
Published: September 2023

As plant-based diets become more popular, there is an interest in developing innovations to improve the bioaccessibility of plant protein. In this study, seven probiotic strains (Bifidobacterium animalis subsp. lactis B420, B. lactis Bl-04, Lactobacillus acidophilus NCFM, Lacticaseibacillus rhamnosus HN001, Lacticaseibacillus paracasei subsp. paracasei Lpc-37, Lactiplantibacillus plantarum Lp-115, and Lactococcus lactis subsp. lactis Ll-23) were evaluated for their capacity to hydrolyze soy and pea protein ingredients in an in vitro digestion model of the upper gastrointestinal tract (UGIT). Compared to the control digestion of protein without a probiotic, all the studied strains were able to increase the digestion of soy or pea protein, as evidenced by an increase in free α-amino nitrogen (FAN) and/or free amino acid concentration. The increase in FAN varied between 13 and 33% depending on the protein substrate and probiotic strain. The survival of probiotic bacteria after exposure to digestive fluids was strain-dependent and may have affected the strain’s capacity to function and aid in protein digestion in the gastrointestinal environment. Overall, our results from the standardized in vitro digestion model provide an approach to explore probiotics for improved plant protein digestion and bioaccessibility of amino acids; however, human clinical research is needed to evaluate the efficacy of probiotics on amino acid absorption and bioavailability in vivo.
Synthesis and Biological Activity of Piperidinothiosemicarbazones Derived from Aminoazinecarbonitriles
Authors: Ziembicka Dagmara , Gobis Katarzyna , Szczesio Małgorzata , Augustynowicz-Kopeć Ewa , Głogowska Agnieszka , Korona-Głowniak Izabela , Bojanowski Krzysztof
Published: September 2023

To investigate how structural modifications affect tuberculostatic potency, we synthesized seven new piperidinothiosemicrabazone derivatives 8–14, in which three of them had a pyrazine ring replacing the pyridine ring. Derivatives 8–9 and 13–14 exhibited significant activity against the standard strain (minimum inhibitory concentration (MIC) 2–4 μg/mL) and even greater activity against the resistant M. tuberculosis strain (MIC 0.5–4 μg/mL). Additionally, the effects of compounds 8–9 were entirely selective (MIC toward other microorganisms ≥ 1000 μg/mL) and non-toxic (IC50 to HaCaT cells 5.8 to >50 μg/mL). The antimycobacterial activity of pyrazine derivatives 11–12 was negligible (MIC 256 to >500 μg/mL), indicating that replacing the aromatic ring was generally not a promising line of research in this case. The zwitterionic structure of compound 11 was determined using X-ray crystallography. Absorption, distribution, metabolism, and excretion (ADME) calculations showed that all compounds, except 11, could be considered for testing as future drugs. An analysis of the structure–activity relationship was carried out, indicating that the higher basicity of the substituent located at the heteroaromatic ring might be of particular importance for the antituberculous activity of the tested groups of compounds.
Transcriptomic Profiling after In Vitro Δ8-THC Exposure Shows Cytoskeletal Remodeling in Trauma-Injured NSC-34 Cell Line
Authors: Chiricosta Luigi , D’Angiolini Simone , Gugliandolo Agnese , Salamone Stefano , Pollastro Federica , Mazzon Emanuela
Published: September 2023

Neuronal cell death is a physiological process that, when uncontrollable, leads to neurodegenerative disorders like spinal cord injury (SCI). SCI represents one of the major causes of trauma and disabilities worldwide for which no effective pharmacological intervention exists. Herein, we observed the beneficial effects of Δ8-Tetrahydrocannabinol (Δ8-THC) during neuronal cell death recovery. We cultured NSC-34 motoneuron cell line performing three different experiments. A traumatic scratch injury was caused in two experiments. One of the scratched was pretreated with Δ8-THC to observe the role of the cannabinoid following the trauma. An experimental control group was neither scratched nor pretreated. All the experiments underwent RNA-seq analysis. The effects of traumatic injury were observed in scratch against control comparison. Comparison of scratch models with or without pretreatment highlighted how Δ8-THC counteracts the traumatic event. Our results shown that Δ8-THC triggers the cytoskeletal remodeling probably due to the activation of the Janus Kinase Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway and the signaling cascade operated by the Mitogen-Activated Protein (MAP) Kinase signaling pathway. In light of this evidence, Δ8-THC could be a valid pharmacological approach in the treatment of abnormal neuronal cell death occurring in motoneuron cells.
Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery
Authors: Du Xuan , Yada Erica , Terai Yuki , Takahashi Takuya , Nakanishi Hideyuki , Tanaka Hiroki , Akita Hidetaka , Itaka Keiji
Published: September 2023

The growing significance of messenger RNA (mRNA) therapeutics in diverse medical applications, such as cancer, infectious diseases, and genetic disorders, highlighted the need for efficient and safe delivery systems. Lipid nanoparticles (LNPs) have shown great promise for mRNA delivery, but challenges such as toxicity and immunogenicity still remain to be addressed. In this study, we aimed to compare the performance of polyplex nanomicelles, our original cationic polymer-based carrier, and LNPs in various aspects, including delivery efficiency, organ toxicity, muscle damage, immune reaction, and pain. Our results showed that nanomicelles (PEG-PAsp(DET)) and LNPs (SM-102) exhibited distinct characteristics, with the former demonstrating relatively sustained protein production and reduced inflammation, making them suitable for therapeutic purposes. On the other hand, LNPs displayed desirable properties for vaccines, such as rapid mRNA expression and potent immune response. Taken together, these results suggest the different potentials of nanomicelles and LNPs, supporting further optimization of mRNA delivery systems tailored for specific purposes.
Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Responding to Pro-Inflammatory Cytokines
Authors: Grabarczyk Mikolaj , Ksiazek-Winiarek Dominika , Glabinski Andrzej , Szpakowski Piotr
Published: September 2023

Astrocytes are considered to be the dominant cell fraction of the central nervous system. They play a supportive and protective role towards neurons, and regulate inflammatory processes; they thus make suitable targets for drugs and supplements, such as polyphenolic compounds. However, due to their wide range, knowledge of their anti-inflammatory potential remains relatively incomplete. The aim of this study was therefore to determine whether myricetin and chrysin are able to decrease chemokine release in reactive astrocytes. To assess the antioxidant and anti-inflammatory potential of polyphenols, human primary astrocytes were cultured in the presence of a reactive and neurotoxic astrocyte-inducing cytokine mixture (TNF-α, IL-1a, C1q), either alone or in the presence of myricetin or chrysin. The examined polyphenols were able to modify the secretion of chemokines by human cortical astrocytes, especially CCL5 (chrysin), CCL1 (myricetin) and CCL2 (both), while cell viability was not affected. Surprisingly, the compounds did not demonstrate any antioxidant properties in the astrocyte cultures.
Mechanism of TCF21 Downregulation Leading to Immunosuppression of Tumor-Associated Macrophages in Non-Small Cell Lung Cancer
Authors: Liu Hong , He Run , Yang Xuliang , Huang Bo , Liu Hongxiang
Published: September 2023

Lung cancer, as one of the high-mortality cancers, seriously affects the normal life of people. Non-small cell lung cancer (NSCLC) accounts for a high proportion of the overall incidence of lung cancer, and identifying therapeutic targets of NSCLC is of vital significance. This study attempted to elucidate the regulatory mechanism of transcription factor 21 (TCF21) on the immunosuppressive effect of tumor-associated macrophages (TAM) in NSCLC. The experimental results revealed that the expression of TCF21 was decreased in lung cancer cells and TAM. Macrophage polarization affected T cell viability and tumor-killing greatly, and M2-type polarization reduced the viability and tumor-killing of CD8+T cells. Meanwhile, overexpression of TCF21 promoted the polarization of TAM to M1 macrophages and the enhancement of macrophages to the viability of T cells. Furthermore, there appears to be a targeting relationship between TCF21 and Notch, suggesting that TCF21 exerts its influence via the Notch signaling pathway. This study demonstrated the polarization regulation of TAM to regulate the immunosuppressive effect, which provides novel targets for the treatment of lung cancer.
Real Aperture Continuous Terahertz Imaging System and Spectral Refinement Method
Authors: Xue Kailiang , Zhang Wenna , Wang Zhaoba , Jin Yong , Guo Xin , Chen Youxing
Published: September 2023

In order to meet the increasing demand of non-destructive testing (NDT) in engineering practice, a continuous terahertz NDT platform based on linear scanning has been developed, with a center frequency of 154 GHz and a bandwidth of 56 GHz. This system combines frequency modulation continuous wave (FMCW) radar technology with a continuous scanning structure, as well as a data acquisition platform to provide a non-contact detection method; this is highly efficient and compensates for the shortcomings of traditional methods such as microwave, X-ray, ultrasonic, and others in safety inspection and special detection. In addition, a signal processing method of spectral refinement and correction is proposed in this paper for accurate thickness measurement. The results show that the method has a high accuracy for ABS, PVC, and ceramic matrix composites. By extracting the characteristic parameters, the detection and imaging of prefabricated defects, such as debonding and bubbles in composite materials, have been successfully achieved. This helps to evaluate the internal state of the inspected object more intuitively and further meets the requirements of industrial NDT.
Implementation or Suppression of the Collective Lasing of the Laser Channels at the Intracavity Spectral Beam Combining
Authors: Kamynin Vladimir A. , Kashin Vitalii V. , Nikolaev Dmitri A. , Tsvetkov Vladimir B.
Published: September 2023

The spectral and spatial output parameters of a two-channel, Yb-doped fiber laser operating in the intracavity spectral beam combining mode were investigated. We showed that by using active media with slightly different gain spectra, it is possible to implement either the spectral combining mode of the independent laser channels or the mode of collective lasing of the channels. The difference in the gain spectra of the active media was realized due to the difference in the threshold inverse population in the Yb-doped fibers.
Imaging through a Scattering Medium under Different Intensities of Ambient Light Interference
Authors: Zhang Yantong , Huang Huiling , Wu Feibin , Han Jun , Yang Yi , Li Ruyi
Published: September 2023

Many solutions for imaging through a scattering medium are sensitive to noise, which can lead to degradation or even to a failure of the image quality. This is especially the case in practical application scenarios, which are always filled with changing ambient light interference; as such, the traditional methods are difficult to practically apply. Therefore, in this paper, a spatial-frequency dual-domain learning neural network is designed for reconstructing the target of a speckle pattern under different intensities of ambient light interference. The network is mainly based on two modules. One module is designed from two perspectives, frequency domain denoising and the spatial-frequency spectrum of the speckle pattern. Another module is a dual-feature fusion attention module, which is used to improve the accuracy of the network. The experimental results demonstrate that the network is capable of reconstructing complex targets with high quality under varying intensities of interfering light. Furthermore, it is not constrained by the optical memory effect, exhibiting remarkable robustness and generalizability. The research based on this paper provides a feasible path for the practical application of scattering imaging methods.