bluuebunny/crossref_metadata_2025 huggingface dataset:
Cover crops improve soil structure and change organic carbon distribution in macroaggregate fractions
Authors: Gentsch Norman , Riechers Florin Laura , Boy Jens , Schweneker Dörte , Feuerstein Ulf , Heuermann Diana , Guggenberger Georg
Published: February 2024

Abstract. Soil structure is sensitive to intensive soil management. It can be ameliorated by a reduction in soil cultivation and stimulation of plant and microbial mediators for aggregate formation, with the latter being a prerequisite and measure for soil quality. Cover crops (CCs) are part of an integrated approach to stabilize or improve soil quality. Thereby, the incorporation of diverse CC mixtures is hypothesized to increase the positive effects of CC applications. This study entailed an investigation of the legacy effect of CCs on soil aggregates after three crop rotations in the second main crop (winter wheat) after the last CC treatment. Four CCs (mustard, phacelia, clover, and oat) cultivated in pure stands and with a fallow treatment were compared to a mixture of the four CC species (Mix4) and a highly diverse 12-plant-species mixture (Mix12) in a long-term field experiment in Germany. The organic carbon (OC) distribution within macroaggregate fractions (16–8, 8–4, 4–2, 2–1, and <1 mm) and their aggregate stability were measured by dry- and wet-sieving methods, and the mean weight diameter (MWD) was calculated from water-stable aggregates. The results showed that, compared to the fallow, all CCs increased the MWD between 10 % and 19 % in soil under the following main crop. The average MWD increase over the fallow was slightly higher for CC mixtures (16 %) than for single CCs (12 %). Most of the OC (67.9 % on average) was stored in the <1 mm aggregate fraction, highest in the topsoil and decreasing with soil depth. The intermediate fractions (8–4 mm, 4–2 mm, 2–1 mm) stored 8.5 %, 10.5 %, and 11.0 % of the total OC, while 2.1 % was stored in the 16–8 mm fraction. Higher MWD improvement at the 20–30 cm depth also indicates additional benefits from a reduction in the cultivation depth. Structural equation modelling (SEM) suggests that single CCs were more likely to increase OC storage in small macroaggregates <1 mm, while CC mixtures were more likely to increase OC in the largest fraction (8–16 mm). Different individual CC species or mixtures exhibited varying involvement in the formation of different aggregate fractions. We provide evidence that litter quality, root morphology, and rhizosphere input, which affect microbial mediators of aggregate formation, might be the main reasons for the observed differences between CC treatments. Cover crops are valuable multifunctional tools for sustainable soil management. Here, we showed that they contribute to structure amelioration in arable soils. Increasing the functional diversity of plant species in CC mixtures could be a strategy to further enhance the positive effects of CCs in agroecosystems.
Efectos positivos del procesamiento visual en el desarrollo de la competencia intercultural de estudiantes chinos de español de nivel intermedio
Authors: Qian Gong , Chenjie Yuan , Yiyang Cheng
Published: February 2024

Estudios previos han demostrado que el procesamiento visual favorece el desarrollo de L2 en general. En vista de que la competencia de L2 implica tanto la competencia lingüística como la intercultural, este estudio se pone foco en investigar si las ayudas visuales sirven para el desarrollo de ambas competencias, o solo una de ellas. A cuarenta estudiantes chinos de español de nivel intermedio se les pidió que completaran una serie de tareas dirigidas tanto al idioma español como a la cultura española después de que se les presentara una seria de materiales: a la mitad se les presentaron los materiales audiovisuales mientras que a la otra mitad se le ofrecieron los auditivos correspendientes. Los resultados muestran que el procesamiento visual beneficia el desarrollo de la competencia intercultural de los estudiantes chinos de español de nivel intermedio, pero apenas juega un papel en el desarrollo de su competencia lingüística. Nuestro hallazgo sugiere que los materiales visuales deben incluirse en la enseñanza de L2 para mejorar el desarrollo de la competencia intercultural de los estudiantes de L2
Sobre variación cultural en comunicación no verbal. Del siglo XIX al siglo XXI: inventarios comparativos de gestos
Authors: Cestero Mancera Ana M.
Published: February 2024

La comunicación no verbal se convirtió en objeto de investigación fundamental de la disciplina independiente conocida por el mismo nombre a mediados del siglo XX; no obstante, se le ha prestado atención desde la antigüedad clásica, lo que ha proporcionado concepciones y tratamientos de la comunicación no verbal que, junto con estudios detallados y profundos, devienen en la creencia actual de que los signos no verbales son parte indispensable de la comunicación humana, y culturales. Tomando como base aportaciones que consideramos fundamentales del siglo XIX y, sobre todo, del siglo XX, en las que se trabaja desde una perspectiva con marcos teórico-metodológicos de corte filosófico, lingüístico, antropológico y psicológico, que han aumentado en empirismo con el paso del tiempo y ofrecen datos significativos y descripciones de gran interés, damos cuenta, en este artículo, de la variación cultural, geolectal, documentada en épocas pasadas y décadas cercanas, en repertorios de gestos contrastivos, que sienta las bases para la investigación presente y futura.
Tradicionalidad discursiva y formularidad del (inicio de) turno en la literatura dialógica a lo largo de la historia del español
Authors: Del Rey Quesada Santiago
Published: February 2024

En este artículo tendremos en cuenta algunas fórmulas típicas de inicio de turno o constituyentes exclusivas de turno en la historia de la literatura española. Estudiaremos la continuidad de la fórmula desde el latín y la variación diacrónica en función de preferencias discursivas (por ejemplo, en lo que respecta a la función de tópico/foco) y sistemáticas (sustitución de esquemas gramaticales, preferencias sintácticas, obsolescencia léxica, etc.). El análisis permitirá comprender la importancia de ciertas tradiciones literarias para la habitualización de determinadas fórmulas, sin olvidar que el diálogo, como categoría (macro-) genérica, es transversal a diferentes subgéneros. Por otro lado, se insistirá en la relevancia del siglo XIX como período clave en la evolución de la oralidad elaborada gracias a la proliferación de la comedia, incluidas las traducciones de los comediógrafos latinos. Concluiremos que las fórmulas dialógicas son manifestación de una tradicionalidad supraidiomática que, en numerosos casos, ha resultado invisible al investigador.
LA SECONDA CONCLUSIONE A CUI ARRIVA HERCOLE FILOGENIO NEL SUO TRATTATO ‘‘DELL’ECCELLENZA DELLA DONNAʼʼ.
Authors: Koutrakis Spiros
Published: February 2024

Nel 1589 Hercole Filogenio scrisse un discorso che intitolò Dell’eccellenza della donna volendo allinearsi ‘‘all’opinione di coloro che si sforzano scoprire l’errore di molti, quali tanto si affannano in avilire il feminil sesso’’ e dedicò il suo scritto a Flavia Peretti Orsina, una donna distinta della sua epoca e dotata di uno spirito inquieto che con i suoi interessi contribuì allo sviluppo della società in cui viveva. Nel suo tentativo di preservare le donne dal biasimo manifestato dal maschilismo egemone e allo stesso tempo elogiare le loro virtù, parte da due conclusioni, l’analisi e l’approfondimento delle quali, per mezzo di un’argomentazione valida, costituiscono il nucleo testuale della sua opera. L’articolo presenta e analizza i ragionamenti che Filogenio sviluppa nella seconda parte del suo discorso sui quali intende imperniare la dimostrazione della seconda conclusione: che la Donna non è superiore né inferiore all’Uomo, ma simile e uguale di nobiltà, d’eccellenza e di perfezione.
Relazioni intertestuali con le scrittrici nel dialogo di Cristoforo Cronzini d’Ancona
Authors: Duraccio Caterina
Published: February 2024

Duranti gli anni della Querelle des femmes si è assistito ad un’importante crescita di testi in difesa o in detrazione della causa femminile. Una delle caratteristiche principali di questa tendenza letteraria risiede nelle reciproche relazioni che le opere stabiliscono tra loro, attraverso una fitta rete di richiami intertestuali. Il Dialogo Della Dignità e della nobiltà delle donne (1624) dello scrittore marchigiano Cristoforo Bronzini aderisce appieno alla pratica intertestuale che mette a servizio della memoria storico-culturale. Nel presente articolo si analizzano i rapporti intertestuali del trattato seicentesco con opere di scrittrici come Lucrezia Marinella, Moderata Fonte ed Isabella Cervoni, mettendo in rilievo le diverse funzioni che l’intertestualità adempie nei testi della Querelle des femmes.
Expresión del ideal femenino en oraciones y canciones fúnebres italianas del siglo XVI
Authors: Bertomeu Masià María José
Published: February 2024

El estudio de algunas oraciones y canciones breves impresas en Italia durante el siglo XVI a la muerte de mujeres de la alta nobleza es una fuente de gran interés para estudiar el lenguaje utilizado para presentarlas como modelos y reducir sus personalidades a concretas características arquetípicas enraizadas en la tradición literaria y filosófica, formuladas en la literatura comportamental para las damas, que se multiplicó a partir de mediados de siglo. En el presente artículo bosquejamos estas características en algunas obras dedicadas a la muerte de tres de las grandes damas de la época en Italia.
Veturia en el Perigynaecon: la defensa de la patria como valor femenino en Mario Equicola
Authors: Rodríguez Mesa Francisco José
Published: February 2024

En 1501, Mario Equicola concluye el Perigynaecon, la única obra filógina que el humanista de Alvito compondría en toda su vida. Este tratado se idea con una clara finalidad instrumental, pues el autor deseaba entrar al servicio de Isabella d’Este, marquesa consorte de Mantua. Precisamente por ello, tras cada uno de los argumentos que Equicola presenta y detrás de cada una de las mujeres ejemplares que menciona para ensalzar el valor femenino a lo largo de la historia se pueden establecer paralelismos más o menos claros con los problemas que Isabella tuvo que afrontar en su primera década en la corte mantuana. En este artículo analizamos la función que Veturia desempeña en el seno del elenco de mujeres ejemplares del Perigynaecon y profundizamos en algunos de los motivos que podrían haber empujado a Equicola a decantarse por incluir a la madre de Coriolano entre las mujeres a las que alude en su tratado.
Escritores filóginos en el debate renacentista sobre las segundas nupcias: Del rimaritarsi de Sperone Speroni
Authors: Martín-Clavijo Milagro
Published: February 2024

En el breve tratado Del rimaritarsi (1542) el humanista italiano Sperone Speroni aborda un tema de interés en el Renacimiento, el de las viudas y las segundas nupcias. Se parte del análisis de este texto y se confronta con los de otros humanistas del mismo periodo, como Erasmo, Fusco, Valier, Trissino, Savonarola, Zarrabin, Cabei, Trotto, Dolce o Vives, para poder entender que la defensa del matrimonio también para la viuda es uno de los elementos clave del nuevo concepto de familia en la sociedad moderna.
Doenças Emergentes e Ambiente na Era do Antropoceno e da Inequidade em Saúde
Authors: A. C. Galvão Luiz
Published: February 2024

O artigo aborda a relação entre doenças emergentes e ambiente, destacando a importância das condições ambientais na propagação e evolução dessas doenças. O texto baseado em uma apresentação feita à ANM aborda como as atividades humanas e sua interação com o ambiente têm desencadeado uma série de efeitos que afetam a saúde global, principalmente das populações vulnerabilizadas por um processo histórico que estruturou uma sociedade desigual, injusta e violenta.
A Mais Grave Doença Emergente Está em Declínio?
Authors: Pretti Dalcolmo Margareth
Published: February 2024

No escopo do seminário Doenças emergentes e reemergentes organizado pela ANM, o objetivo deste texto é considerar o histórico da Covid19, doença assim denominada pela Organização Mundial da Saúde, em março de 2020, e seu prognóstico epidemiológico, após o aparecimento de novas cepas a partir da cepa ancestral de Wuhan. Antecedido pelos países europeus mais atingidos como Itália e Espanha, no Brasil, o primeiro caso foi diagnosticado em fevereiro de 2020, num paciente de 61 anos que viajará à Itália. A vacinação em massa, iniciada em janeiro de 2021, resultou em grande impacto reduzindo a gravidade dos casos, hospitalizações e mortes. O desafio atual é o tratamento de milhares de pessoas com sequelas da Covid19, ou Covid longa, que necessitam reabilitação.
Doenças Emergentes e Reemergentes: Contribuições da Diplomacia da Saúde para Seu Enfrentamento
Authors: Marchiori Buss Paulo , Reges Paula
Published: February 2024

Este artigo examina a resposta do sistema multilateral das Nações Unidas às doenças emergentes e reemergentes, com focos na Secretaria Geral (SG), Assembleia Geral das Nações Unidas (AGNU) e na agência especializada em saúde, a OMS e seu braço hemisférico, a Organização Pan-americana da Saúde (Opas), do início da pandemia de COVID-19, ao redor de janeiro de 2020, até a última Assembleia Mundial da Saúde (maio de 2023) e a última AGNU (setembro de 2023). A metodologia utilizada foi identificar e analisar os principais textos produzidos no âmbito do sistema multilateral, vale dizer suas resoluções, documentos básicos e declarações referentes ao tema, destacando e comentando criticamente suas principais conclusões.
AIDS, DoençaEmergente Que Permanece
Authors: Grinsztejn Beatriz , Moreira Jalil Emilia , Gonçalves Veloso Valdileia
Published: February 2024

No início da década de 1980, a epidemia de AIDS surpreendeu o mundo. Apesar do sucesso inquestionável na resposta ao HIV nas últimas quatro décadas, muitos desafios e necessidades não atendidas permanecem. Em 2021, 38 milhões de pessoas viviam com HIV em todo o mundo, com 1,5 milhão de novas infecções anuais. O tratamento passou a esquemas cada vez mais seguros, melhor tolerados, mais fáceis de administrar e mais eficazes. Dados os desafios associados à adesão à terapia diária, os esforços atuais estão focados no desenvolvimento de esquemas antiretrovirais com ação mais longa ou liberação prolongada. Em paralelo, as estratégias biomédicas revolucionaram a prevenção do HIV nos últimos 15 anos.
The rates of different crimes and the use of illicit substances before and during imprisonment among prisoners
Authors: Shakeel Muhammad , Khan Umair , Shakeel Adeela
Published: February 2024

Introduction: There is a strong association between the use of substances and criminal behaviour. The use of illicit substances is not only a criminal act, but it also predisposes a person to other crimes. As the use of illicit substances is quite common among criminals, similarly the rate of crimes is also high among substance users.
Objectives: To document the rates of different crimes among prisoners and the rates of the use of different substances among them before and during imprisonment.
Materials & Methods: In this observational study, 327 sample size was achieved through systematic probability sampling technique from central prison Haripur from November to December 2022. Data were analyzed for descriptive statistics through SPSS 24; rates and  percentages were calculated for categorical variables, while the mean and standard deviation were calculated for continuous variables.
Results: The prisoners were almost all males (99.1%) with only 0.9% females. The mean age of the prisoners was 38.64 ± 12.57 years. The most common crime was murder (44.5%). The lifetime rate of the use of tobacco before imprisonment was 63.3% while it increased up to 67.3% during imprisonment. Almost 32.75% reported the use of illicit substances before imprisonment while 23.5% were still using illicit substances inside the prison.
Conclusion: Imprisonment does not cessate the habit of substance use by prisoners, it merely alters the pattern and magnitude of the problem, in relation to ease of access of illicit substances.
Performance Obstacles Usually Experience by Critical Care Nurses
Authors: Rahman Ihsanur , Ullah Imdad , Ullah Naveed , Dad Afsar
Published: February 2024

Introduction: Nursing care and patient safety may be significantly associated with the work environment of critical care nurses. The key factors affect nurse's outcome have not been clearly identified so that, to provide clear indication to redesign the work environment and improve the nursing care and patients’ safety. Performance obstacles are the main factors to prevent the capability of nurses to perform their task effectively related to their working environment.
Objective: To identify the performance obstacles commonly experienced by critical care nurses in their work environment in tertiary care hospitals Peshawar, Khyber Pakhtunkhwa, Pakistan.
Methodology: A mixed methods and cross-sectional study conducted in tertiary care hospitals Peshawar. Data were collected via convenient sampling through pre structured validated and adopted questionnaire, and univariate analyses was applied using SPSS. The key performance obstacles were reported by Critical care nurses.
Results: Critical care nurses (N=129) from three hospitals in Peshawar participated in the study. The most prominent performance obstacles were; spent much time for teaching family members (76%), delay in receiving medications from pharmacy (64.3%), distraction from family members, and delay in receiving medical orders (51.9% and 51.9%) respectively.
Conclusion: Critical care nurses usually experience various performance obstacles in their daily work environment. Further study on performance obstacles is the time demand on nursing work burden, quality of care and patients’ safety. Apart from these obstacles there is a need for redesigning of the work environment of critical care nurses to overcome these obstacles.
Immunochromatographic Detection of SARS CoV-2 Antigen In Comparison With the Polymerase Chain Reaction for Laboratory Diagnosis of Covid-19 in Karachi, Pakistan
Authors: Abbas Muhammad , Iqbal Nasima , Ullah Rahman , Ur Rahman Waheed , Ullah Habib
Published: February 2024

Introduction: The Covid-19 pandemic raised the question of which laboratory test was relevant for a rapid and accurate diagnosis of the disease. The current two methods for the detection of SARS CoV-2 are the ICT (Immunochromatographic Technique) and the PCR (Polymerase Chain Reaction) tests; therefore comparative analysis of test performance has to be done.
Objective: To perform a comparative analysis of two different techniques (Immunochromatographic technique for Antigen and Polymerase Chain Reaction for RNA) which are implicated for the detection of SARS CoV-2.
Materials & Methods: The Rapid Antigen Test (RAT) and Polymerase Chain Reaction (PCR) were performed for the detection of Covid-19 on individuals having the signs and symptoms of SARS Covid-19. Immunochromatographic technique (ICT) was performed by SD Biosensor kits, while for Polymerase Chain Reaction RNA extraction was performed by Liferiver® auto extraction analyzer, and amplification was performed by SLAN®-48P Real-Time PCR System.
Results: Among of 100 samples tested, 62 (23.56%) were positive on ICT while PCR had 66 (22.44%) and 38 were negative on ICT while PCR had 34. Thus the sensitivity of ICT was 90.77% (95% CI, 80.98% - 96.54%) and specificity was 91.43% (95% CI 76.94%-98.20%). The Positive Predictive Value was 95.16% while the Negative Predictive Value was 84.21%. However the Cohen’s Kappa Index Value was recorded as 0.806.
Conclusion: The clinical performance of SD Biosensor Roche kits was excellent. On the basis of sensitivity and specificity it was concluded that RAT have comparable results with RT PCR.
Keywords: Antigen, COVID-19, diagnosis, immunoassay, PCR, SARS-CoV-2.
Stress levels and the factors associated with perceived stress among medical students
Authors: Yasmeen Qamar , Yasmeen Nighat , Yasmeen Summaira
Published: February 2024

Introduction: The life of a medical student is stressful due to a variety of known and modifiable factors that tend to affect their academic output. Identification and amelioration of these stressors would go a long way to improve medical education.

Objective: To assess stress levels and factors associated with perceived stress among medical students.

Materials & Methods: A cross sectional study was conducted from March 2022 to June 2022 on 409 randomly selected preclinical and clinical students of different medical colleges of Faisalabad, Punjab, Pakistan. A structured questionnaire was used for data collection about socio-demographic characteristics and potential risk factors (personal, environmental, academic) related to stress. The Kessler Psychological Distress Instrument (K10) was used for assessment of perceived stress levels.  Data analysis was done with SPSS version 21 for descriptive statistics.

Results: Most students were of the age group of 18-20 years (46.7%) with 55.3% males and 44.7% females.  Majority of students (59.2%) students were day scholars with 40.8% resident in hostels. According to K10 scale, 7.8% students were normal, 49.6% had mild stress, and 32.1% had moderate stress. Severe stress was present in 10.5% of medical students. Levels of stress were positively associated with Academic, Psychosocial, Environmental, and Health Related stressors.

Conclusion: Medical students of the selected colleges in Faisalabad suffered considerable levels of stress related to a number of modifiable factors that affected their academic performance.
Recurrence of pulmonary tuberculosis associated with non-specific lung diseases – a current problem in phthisiopneumology
Authors: Tudor Elena , Moscovciuc Ana , Simionica Iurie , Sincarenco Marina , Iavorschi Constantin , Brumaru Albina , Rivneac Lidia , Pirlog Irina
Published: February 2024

The analysis of the specialized literature demonstrates an increase in the incidence of pulmonary tuberculosis recurrence. In the development of relapse of pulmonary tuberculosis an important role belongs to comorbidities, among which non-specific lung diseases are of major importance. The association of tuberculosis with non-specific lung diseases determines the presence of a syndrome of mutual aggravation, characterized by severe clinical symptoms.
Tuberculosis of the larynx – aspects of diagnosis and treatment
Authors: Tudor Elena , Cabac Vasile , Budu Ana-Maria , Cernev Daniela , Osman Victor
Published: February 2024

Tuberculosis is a chronic infectious and transmissible disease caused by Mycobacterium tuberculosis. It represents the most common granulomatous pathology affecting the larynx. In most cases it is secondary to pulmonary tuberculosis. Laryngeal tuberculosis is a public health problem due to changes in the clinical pattern of the disease that frequently leads to misdiagnosis and delayed treatment, which increases the risk of contagion. The purpose of this paper is to highlight the diagnostic and treatment aspects of laryngeal tuberculosis.
From the medical to the bio-psychosocial approach of COPD patients through the lens of the International Classification of Functioning, Disability and Health
Authors: Condratchi Diana
Published: February 2024

The article presents the literature review, in which the results of the research regarding the course of the medico-social expertise over the years are presented, starting from the medical and work expertise and with the elucidation of the latest bio-psychosocial approaches of the disabled person. At the same time, the article reflects the principles of implementation of the International Classification of Functioning, Disability and Health in patients with COPD. The following databases were used as a source of scientific literature: Google Scholar, PubMed and eLibrary. The keywords that were used in the search: "COPD", "CIF", "numeric codes", "bio-psychosocial model of disability".
Diálogos em direito: a sociedade, a lei e os tribunais – volume 2
Authors:   Hildeliza Boechat Cabral,   Alinne Arquette,   Moyana Robles-Lessa
Published: February 2024

Ao nos deparamos com a organização de um segundo volume, é possível identificar e reconhecer a importância do Direito — enquanto ciência — a toda organização social. Afinal, a função social do Direito é organizar socialmente a vida cotidiana dos cidadãos, e sem diálogo não é possível adequar direitos, deveres e interesses sociais. Este segundo volume dá continuidade aos objetivos do primeiro, abordando, de modo interdisciplinar, temas contemporâneos e de interesse social. Sua construção teve como intuito contribuir com debates e reflexões pertinentes a este tempo de profundas transformações sociais, movido por inovações tecnológicas, pelo conhecimento genérico da internet e pela fugacidade das conexões. É nosso desejo que os diálogos propostos nesta obra colaborem com o entendimento, a experiência e a prática de um Direito equânime.
Evaluation of Antioxidant and Dermato-protective activities of Origanum vulgare extracts
Authors: Belhacini Nadjiba , Alem Karima , Boumendjel Amel , Messarah Mahfoud
Published: February 2024

Medicinal plants represent an economic and accessible natural reservoir of new molecules with biological activities. This study aims to investigate the potential use of "Origanum vulgare", a medicinal plant native to Skikda-Algeria, as a origin of bioactive compounds with antioxidant and photo-protective properties. To this end, the plant's extracts were tested in vitro using four different methods to measure their ability to inhibit free radicals. The extracts were also tested for their capacity to protect skin from sun's rays by measuring their sun protection factor (SPF). The obtained results showed that Origanum vulgare contained high levels of total polyphenols and flavonols with strong antioxidant and photo-protective properties in its extracts, thus suggesting its potential therapeutic applications as a valuable natural resource for the pharmaceutical industry. This plant was also proven to have a very important inhibition of free radicals where ethyl acetate and N butanol extracts had the best IC50 and A0.5 with significant values in some tests lower than the standards. The SPF measure showed high photo-protective activity with an SPF of 47.29±0.00, 47.30±0.00, and 47.21±0.14 respectively. This suggests that the extracts could potentially be used in cosmetic formulations and as a skincare agent. Overall, the plant of Origanum vulgare can represent an interesting source of bioactive compounds, and consequently, the extracts can be useful in the pharmaceutical field for various therapeutic applications.
Spectrophotometric Multi-Component Quantitation of Rosiglitazone, Glibenclamide and Metformin HCl in Pharmaceutical Dosages Form by using Cramer’s Matrix
Authors: Singh Baghel Uttam , Sharma Abhay , Gautam Harshit , Mukim Mohammad , Singh Deeksha , Dave Shuchi , Srivastava B. , Singh Bhawani
Published: February 2024

Objective: This article illustrates the development of a simple, precise and accurate spectrophotometric analysis method for the determination of Rosiglitazone, Glibenclamide and Metformin hydrochloride in their pharmaceutical preparations by using Cramer's matrix. Method: The absorbance of the sample solution was measured at 315.6nm and 229.2nm for the estimation of rosiglitazone and glibenclamide, respectively and at 237.0nm for estimation of metformin hydrochloride by Shimadzu double beam UV-visible spectrophotometer. Results: The result of the analysis for method was tested and validated for various parameters according to ICH guidelines and found satisfactory. The method was successfully applied for the determination of these drugs in their tablet dosage forms. Conclusion: Simultaneous estimation of active ingredients in multicomponent pharmaceutical products normally requires the use of chromatographic separation techniques, like thin layer chromatography, high performance thin layer chromatography, high performance liquid chromatography or gas chromatography etc., followed by their quantitation. But this article illustrates direct spectroscopic estimation of multicomponent formulation by using Cramer's matrix.
Profession for the Magnitude of Temperature and Exposure time on Opuntia elatior cladode extraction on percent yield using design expert software
Authors: Abdul Ahad Hindustan , Abdalla Abdelaziz Mazin Aboobaida , Bakrey Hossamaldeen , Abdu Abdulkadir , Elshiekh Mohamed Yassin Babkir , A. Noureldeen Amal.
Published: February 2024

The drive of the currentexamination is to decide the consequence of temperature and duration on Opuntia elatior cladodes extraction. The literature claims that little attempt was made to extract from cladodes and other plant parts. The effect of dependent factors on the independent response was not attempted to be screened for. The effect of the dependent variable on the answer was controlled during the experiment's design by the Design Expert. The effect of independent variables (temperature and exposure duration) on the response (% yield) could also be evaluated by positioning, authenticating, and hauling out samples in the water. The extraction and exposure times are directly proportional, and the research found that 40°C is the best temperature for removing the substance from cladodes.
Comparative Evaluation of Formulations Designed using Chemically Modified Pectin and Eudragit for Sustained Release of Nateglinide
Authors: J. Shinde Anilkumar , S. Khandekar Sachin , S. Bhatia Manish , A. Tamboli Firoj , J. Jarag Ravindra , N. More Harinath
Published: February 2024

The present work was proposed to chemically modified Pectin with its hydrophilicity reduced and potential for being an universal excipient. The Bulk densities of NTGT granules were found to be 0.3473 which indicate good packing capacity. Carr’s index of NTGT granules were found to be 5.88 which indicate excellent flow properties. Hausner ratio of NTGT granules were found to be 1.0621. Angle of repose of NTGT granules were excellent flow properties. The formulations MP1P2 after optimization to limit the release in the first 3 hrs could also be equally effective. Comparative evaluation of the designed formulations, the release of nateglinide from tablets coated with eudragit RL100 was progressively prolonged, as concentration of eudragit in the coating solution was increased about 63.91% at 12hr of NTGEUD3 batch. The formulated batches gives a clear indication that once daily formulations of nateglinide as oral hypoglycemics drug can be designed using this approach and subsequent release at a consistently uniform rate for sustained action has been achieved.
Project management of the lifecycle of students' research projects in higher pharmaceutical education
Authors: Litvinova T.M. , Galuzina I.I. , Babaskina L.I. , Babaskin D.V. , Glazkova I.U. , Savinova O.V.
Published: February 2024

Management of students' research activities in recent years has been following the principles of project management, which involves the inclusion of project lifecycle management models. The aim is to determine the possibilities of using project lifecycle management models based on the Project Management Institute Project Management Body of Knowledge-6 methods in the research projects made by students receiving higher pharmaceutical education. The models under study are rigid (cascade, iterative, V-model) and flexible models (Agile models, AZ model). The assessment was carried out by 19 experts in the fields of knowledge of the Six-Pointed Star Project Management Body of Knowledge model according to the Likert scale. It has been established that rigid and flexible models can be selectively applied in the research of junior and senior students, depending on the priority of individual areas of knowledge of the Six-Pointed Star Project Management Body of Knowledge model and the scale of work. Among rigid models, the iterative model and the V-model were better than the cascade model in some areas of knowledge and at a certain scale of the research project. Among flexible models, Agile models outperformed the AZ model in terms of time and cost, and the AZ model was better than Agile models in terms of quality and risk. The preferential opportunities for the application of project lifecycle management models in the students' research projects in each of the fields of knowledge of the Six-Pointed Star Project Management Body of Knowledge model have been shown. For a more detailed study of the process of choosing a project lifecycle management model for students' research projects, it is necessary to create an algorithm for this process.
Chiral Lewis Bases for Asymmetric Organocatalysis
Authors: Waser Mario
Published: February 2024

Chiral Lewis bases (LBs) are versatile nucleophilic organocatalysts that allow for numerous highly enantioselective transformations. Over the last years our group had a strong interest in the utilization of chiral LBs (i.e. isothioureas, phosphines, amines) for the activation and control of simple carboxylic acid derivatives (via in situ C1 ammonium enolate formation) and allenoates (via in situ betaine formation) for numerous applications. In this presentation I will give an overview of our most recent results, presenting past and ongoing investigations focusing on the development and mechanistic understanding of new cyclization reactions as well as new a-functionalization chemistry.
INVESTIGATING THE STRESS-STRAIN STATE OF OBTAINING BIMETALLIC PIPES THROUGH COMPUTER MODELING
Authors: BABAYAN A.A. , BALASANYAN B.S. , PETROSYAN G.L.
Published: February 2024

The problem is solved with dimensionless quantities. This makes it possible to obta¬in solutions from bimetallic composite pipes taking into account the real properties of any solid material, as well as bimetallic materials with different porosities.
The inner tube of the bimetallic pipe is in a state of plane stress. The differential equation of the element of the conical part of the pipe and the Laplace equation of a thin-walled cylindrical pipe in a conical matrix, as well as a simplified form of the Mises plasticity condition are investigated. As a result, by integrating the obtained differential equation, formulas for determining dimensionless meridional and circumferential stresses are obtained, as well as current porosities v. In addition, to determine v, formulas from the deformation plasticity theory of porous materials are used.
The outer tube of the bimetallic pipe is in a state of dimensional stress. As a result, the Laplace equation and the simplified plasticity condition change compared to the previous one.
Numerical calculations of the stress-strain state of bimetallic completing pipes are carried out in the MS EXCEL software environment. In particular, computer modeling of the outer pipe is carried out by the preliminary determination of various initial values of the meridional dimensionless stress σ ̅_m0. It is shown that to the pipe extrusion process corresponds an initial stress value σ ̅_m0 at which the meridional stress σ ̅_m of the pipe upon the exiting value is zero.
STUDYING THE PROCESS OF SULFIDING AN OXIDIZED COPPER ORE BY THE METHOD OF MECHANOCHEMICAL ACTIVATION
Authors: AVAGYAN H.V.
Published: February 2024

In recent years, a new direction has appeared in metallurgical processes according to which the processing of concentrates is carried out by a combination of mechanical and metal-thermal methods of recovery. This contributes to the intensification of further redox processes and the production of fundamentally new modified products.
In the case of enrichment of oxidized copper minerals, a more acceptable type of surface activation are mechanical activation processes with a combination of added reagents. It is established that sulfiding of oxidized copper minerals with elemental sulfur, silicon and sodium sulfides proceeds actively. As a result of the research, the optimal modes of sulfiding oxidized copper ores are determined.
As a result of comprehensive research, a technology has been developed for processing oxidized copper minerals in a mill by sulfiding and subsequent flotation.
DEVELOPING A SUN TRACKING SYSTEM IN THE DISCRETE MODE OF SOLAR STATIONS
Authors: AGHABEKYAN D.V. , AYVAZYAN A.G. , TOVMASYAN R.A. , VARDANYAN A.A.
Published: February 2024

A solar tracking system in discrete control mode has been developed and tested for solar stations. It has been shown that the use of short positioning stops leads to a reduction in the power consumption of the rotary device several times, while the daily power generation decreases slightly.
AN ACCURACY IMPROVEMENT TECHNIQUE FOR ON-CHIP CURRENT SOURCES
Authors: SAHAKYAN V.A.
Published: February 2024

A new design technique for accuracy improvement of on-chip reference current sources is proposed. A mathematical model has been developed describing the operation of the proposed technique. Based on the obtained equations, the variation of the reference current caused by the changes in operating conditions and process inaccuracies of the technological should not exceed 1…2%. The proposed technique has been implemented in the design of on-chip reference current source circuit in 14 nm FinFet technology. Spice simulations performed for the developed circuit show less than ± 5% variation of the reference current in the -40...1250C temperature range considering the process variations in ±3 sigma range. The circuit keeps that accuracy for the supply voltage drop up to 0.66 V.
A PAGE FROM THE HISTORY OF THE FORMATION OF ARTSAKH STATE UNIVERSITY
Authors: HARUTYUNYAN M.A. , AVANESYAN A.S.
Published: February 2024

The creation of Artsakh State University became an important event in the cultural life of the newly independent Nagorno-Karabakh Republic. In a difficult period for the people of Artsakh, a historiographic reinterpretation of the process of founding a state university is required in terms of assessing the memorable anniversary, showing political courage at the right time and disseminating the experience of the recent past, making flexible decisions, and finding effective approaches to solving the problems facing the higher educational system of Republic of Artsakh in current situation.
The purpose of this study is to clarify the founding process of the Artsakh State University on the basis of archival documents and works that have acquired primary source value, and to reinterpred its historical significance for the scientific and educational system of Republic of Artsakh.
To achieve this goal, the following research tasks were proposed and solved. Firstly, the educational, political and moral significance of the inclusion of the former Stepanakert State Pedagogical Institute in the higher education al system of the Armenian SSR for the democratic struggle of the population of Nagorno-Karabakh for reunification with the Armenian SSR is shown, State Pedagogical Institute into the system of universities of the Armenian SSR in the context of a long-term policy of integrating institutions-enterprises of Nagorno-Karabakh into the corresponding structures of the Armenian SSR, overcoming legislative and bureaucratic obstacles under the conditions of Soviet totalitarianism with the active support of our compatriots from the Armenian SSR, we noted the creation of the Artsakh State University as one of the symbols of the statehood of the NKR and one of the forges of qualified personnel.
Rezension von: Deutsche in aller Welt : VDA-Abreisskalender, 1937
Authors: Schäfer Josef
Published: February 2024

Deutsche in aller Welt. VDA-Abreisskalender, hg. vom Volksbund für das Deutschtum im Ausland, für das Jahr 1937, Berlin : VDA, 1936.
Rezension von: DJH-Wanderführer, Bd. 1
Authors: Senn Ernst , Reichsverband für Deutsche Jugendherbergen. Gau Schwaben
Published: February 2024

Von Jugendherberge zu Jugendherberge durch das schöne Schwabenland. Wanderungen, Jugendherbergen u. Ortsgruppen in Württemberg u. Hohenzollern u. in den Nachbargauen, hg vom Gau Schwaben e.V. im Reichsverband für Deutsche Jugendherbergen, Bd. 1, 11., neu bearb. Auflage, Stuttgart : Gau Schwaben im Reichsverband für Deutsche Jugendherbergen, 1934. 255 Seiten : Ill., Kt.
Rezension von: Nolle, Albert, Geschichte des Zeitungswesens in Hohenzollern von seinen ersten Anfängen bis zum Jahre 1850
Authors: Senn Ernst , Nolle Albert
Published: February 2024

Albert Nolle: Geschichte des Zeitungswesens in Hohenzollern von seinen ersten Anfängen bis zum Jahre 1850, Diss. masch., München 1934. 108 Seiten.
Which came first? An association between Fournier’s gangrene and a presentation of priapism
Authors: Sarver Jordan , Farley Remington , Tapper Alexander
Published: February 2024

Introduction: Fournier’s gangrene and priapism are two urological emergencies that have a similar goal of prompt surgical evaluation.

Case Report: A 62-year-old male was presented for perineal pain along with a rigid phallus. He was found to have a necrotizing infection of his suprapubic region, scrotum, phallus, and corporal bodies associated with a presentation of priapism.

Conclusion: Prior case studies have reported isolated Fournier’s gangrene to the penile shaft, corpora of the penis, and even more unique in the penile corpora with an associated diagnosis of priapism. Here we present one of the only known cases of Fournier’s gangrene associated with a presentation of priapism.
CRITERIA FOR ULTRASOUND SUSPICION OF THYROID NODULE
Authors: Radia. Benyahia  , Ali. Gaoua  , Kamel. Hail  , Chahira Mazouzi  , Nabil Raa  , SE. Bendib
Published: February 2024

A thyroid nodule is a formation well differentiated from the rest of the thyroid. It represents the most frequent thyroidpathology, and the majority of these nodules are benign. Assessment of patients with thyroid nodules includes history,clinical examination, TSH measurement and thyroid ultrasound.In this article, we will detail the criteria for suspicion, including the place of ultrasound in the evaluation of thyroidnodules, based on the EU-TIRADS criteria
Understanding The Role Of Health Literacy In Self-Medication: Findings From A Cross-Sectional Study In West Godavari District Of Andhra Pradesh
Authors: Balla Sri Krishna Veni , Yanamadala Dr. Pavan Kumar , Gogulamanda Rupa Lavanya , Eduresi Manjusha , Palivela Nandini , Nagabathula Hepsibha , Srisurya K. L. N. S. , Danduprolu Durga Bhavani
Published: February 2024

Background: Self-medication is the practice of treating any ailment or symptom that a person diagnoses for themselves without first visiting a physician. Different communities display different behaviours; hence the purpose of this study is to statistically investigate the patterns and prevalence of self-medication usage. Although health literacy practices have been increasingly recommended in public health literature, there is a lack of studies that examine the relationships between health literacy and self-medication. Methodology: A quantitative, descriptive, cross-sectional, community-based research approach was used in a sample of 316 participants. Health literacy was measured by Single Item Literacy Screener. Data was analysed using SPSS 29.0 version. Results: A total of 316 participants agreed to participate (63.9% were females). The results showed that more than half, 53.4% had adequate health literacy. The prevalence of self-medication was 74%, in these 52% had used medicines by previous prescription and 8% used alternative medicine. There was a significant relationship between the overall health literacy level and practice of self-medication. Conclusion: Improving the health literacy level of the public can reduce inappropriate self-medication Therefore, the design and implementation of training programs are necessary to increase the perception on the risk of self-medication. Appropriate reading skills are important for accessing health information, using health care services, and achieving desirable health outcomes.
Anti-Diabetic Evaluation Of The Traditional Siddha Polyherbal Formulation - Madhu Mukthi Kudineer Chooranum By In Silico Analysis
Authors: Rajamanickam Dr. Baskar , Govindaraju Dr. Bharathkumar , Selvaraaju Dr. Selvapriya Sikkal , Thangarasu Dr. Hemadevi , kareem Dr. Shameem Fathima Abdul
Published: February 2024

Background: From ancient times Siddha medicines have been proven to treat a wide range of communicable and noncommunicable diseases. In India, the number of people affected with diabetes is increasing drastically and it is considered as an epidemic. Purpose: To assess the anti-diabetic activity of the active compounds of the polyherbal formulation – Madhu Mukthi Kudineer Chooranum (MKC) by docking against potent enzymes involved in diabetes mellitus by in silico method. Methods: The major target enzymes Dipeptidyl peptidase, Glycogen synthase kinase - 3β, Alpha-glucosidase and Alpha-amylase were docked against the 10 active compounds present in the MKC using Auto Dock tools. Conclusion: The strong interactions between the target enzymes and the active compounds proved the anti-diabetic efficacy of the MKC formulation. Thus, the intake of MKC has potential benefits in the treatment of Type II Diabetes Mellitus.
Importância e Relevância do Brazilian Journal of Transplantation para a Transplantação Brasileira
Authors: Boin Ilka de Fatima Santana Ferreira , Haddad Luciana , Ferreira Gustavo Fernandes
Published: February 2024

O Brazilian Journal of Transplantation, por meio de sua atuação e comprometimento com altos padrões éticos e acadêmicos, almeja consolidar-se como uma referência na disseminação de conhecimento e avanço científico no campo dos transplantes, tanto nacional quanto internacionalmente. É inegável a contribuição social da BJT como um veículo de divulgação confiável e avaliado por pares. Alcança não apenas a comunidade científica, mas também a população em geral, desmistificando os processos de doação de órgãos, evidenciando o modelo de distribuição dos órgãos por meio da fila única nacional e sensibilizando para a necessidade da doação.
A strategic guide for solving problems in precipitation gravimetric analysis
Authors: Rodrigues Alex Bruno Lobato , Rodrigues Magda Luzia Pantoja , Lobato Ana Paula Freire , De Oliveira Heliana Marques , Soares Francisco de Souza , Florentino Alexandro Cezar , Malheiros Joaquina Barboza
Published: February 2024

This study evaluated the use of a heuristic table as a pedagogical tool for solving the problems of gravimetric analysis by precipitation in analytical chemistry. Targeting undergraduate chemistry students, this study adopts a qualitative-quantitative approach and employs an action research methodology. The central hypothesis suggests that the heuristic table facilitates the interpretation, data organization, and analysis of gravimetric problems. The results indicated a significant improvement in students' understanding and skills following the introduction of the table, indicating its efficacy as a meaningful learning tool (p-value < 0.05). This study contributes to the development and validation of effective didactic methodological approaches in analytical chemistry to promote meaningful learning.