bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of the adult facilitator in accompanying child survivors of violence
Authors:   Ivanovo State Medical Academy, Pchelintseva Evgenia V.
Published: September 2023

The article is devoted to the current problem of facilitating technology of accompanying children who have survived violence, used by adults in the process of organizing free creative play, displaying the child’s experiences and traumatic events. Currently in Russia there is a process of spreading violence against children, which is caused by socio-economic instability and social divisions in society. There is no doubt that preschool age is the most sensitive, sensory stage of formation of moral concepts of ‘good’ and ‘evil’, personal qualities of empathy, sympathy, empathy. However, the dominance in society of aggressiveness and egoistic manifestations on the part of adults, has a serious impact on the socialization of the personality — engenders a state of emotional deprivation of the child to the mother, hypocrisy and adaptation to those forms of behavior that will be advantageous for the child to avoid punishment or all sorts of humiliation in front of adults. The sphere of special interest in the presented format is the innovative search for means and methods that ensure the restoration of the psycho-emotional state of the personality of a child who has experienced adult violence. Special attention in the article is paid to such categories as facilitator, free creative play as a leading means of overcoming the consequences of psychological confusion of a person who has experienced violence, his/her detachment from society, depression, as well as aggression in relations with other subjects, which is often encountered in the created conditions. The scientific understanding of the use in the format of technology of the method of free creative play as a joint activity of an adult with a child, focused on the development of children’s independence, initiative of personality, consistent with the age and individual preferences, leading to the correction of psycho-traumatic consequences of violence, providing positive dynamics of emotional and cognitive spheres of the psyche is outlined
Education of tolerant attitude of design students to the needs of different age groups of the population
Authors:   Magnitogorsk State Technical University n.a. G.I. Nosova, Zhdanova Nadezhda S.
Published: September 2023

The article summarizes the experience of fostering a tolerant attitude of students-future designers in the process of designing interiors for people of different age groups. Many years of experience show that most of the students try to take for designing the life situation that they know best, that is, their age group. The expansion of the age limits of consumers ensures not only the deepening of all project competencies, but also allows the educational process to be carried out: to form a tolerant attitude towards the characteristics of people. The process of implementation of design projects provides an active and varied activity of students, which stimulates the positive development of the individual.
Corporate training of employees in lean manufacturing methods and tools
Authors:   Kazan Innovation University named after V.G. Timiryasov, Chelnokova Tatiana A. , Krasnov Timur E.
Published: September 2023

As part of the urgent tasks of organizing corporate training and staff development in companies, the solutions implemented in the leading electric grid company of the Republic of Tatarstan — JSC “Grid Company”, on the organization of its own educational course aimed at mastering the methods and tools of lean production by employees of the enterprise are considered. The article describes the theoretical justification and experimental approbation of pedagogical and organizational conditions for corporate training of employees in lean production methods and tools. The analysis of the factors that most affect the effectiveness of the development of the corporate training system is carried out. The experience of organizing targeted training of the company’s employees with a sufficient level of theoretical knowledge and practical experience in the field of implementing lean production methods and tools for their pedagogical activities within the organization in order to effectively train all the company’s personnel is considered. The indicators of readiness of an employee of the company to carry out pedagogical activities, as well as indicators of the level of development of the educational program by trainees are presented. In the final part of the article, recommendations are given to organizations planning to organize their own corporate training, having prepared for this training their own staff-teachers who have a sufficient level of knowledge and experience on the topic of the planned corporate training.
A instrução pública nas páginas do jornal católico O Mariano (1935-1956)
Authors: Sousa Ormano Queiroz de , Colares Anselmo Alencar
Published: September 2023

O presente artigo faz uma abordagem acerca da instrução pública registrada em Santarém, Pará, no período de 1935 a 1956, recorte temporal relativo à existência do jornal católico O Mariano, periódico que teve relevância pelo contexto histórico registrado em suas páginas, balizado na ideologia católica, nas quais transpareciam informações de áreas variadas norteando o doutrinamento religioso. Entrelaçam-se as informações com o contexto político do Estado Novo de Getúlio Vargas, buscando a percepção da relação Estado e Igreja. Em meio às notícias veiculava também informações da instrução escolar, o que determinou a pesquisa realizada nesse veículo de comunicação da Congregação Mariana dos Moços de Santarém, grupo de religiosos leigos, posteriormente sendo transformado em órgão oficial da então Prelazia de Santarém, hoje arquidiocese. No norteamento do estudo, adotou-se como percurso metodológico a pesquisa bibliográfica e documental, e para sua análise histórico-crítica levantaram-se problematizações que deram suporte para as linhas norteadoras dando a possibilidade de delinear a substância da análise acerca da compreensão da instrução e sua prática em Santarém naquele período. Investigou-se a relação da instrução educacional com as possíveis concepções dadas pela imprensa católica santarena na primeira metade e no primeiro decênio da segunda metade do século XX. Constatou-se interesses implícitos veiculados nas notícias caracterizando a proposta educacional católica e suas interfaces com orientações oficiais do Estado brasileiro naquele período.
Parvovirus B19 and Human Parvovirus 4 Encode a Homologous “X Protein” in a Reading Frame Overlapping the VP1 Capsid Gene: A VP1/X Overlap in Parvovirus B19 and PARV4
Authors: Karlin David G
Published: September 2023

Viruses frequently contain overlapping genes, which encode functionally unrelated proteins from the same DNA or RNA region but in different reading frames. Yet overlapping genes are often overlooked during genome annotation, in particular in DNA viruses. Here we looked for the presence of overlapping genes likely to encode a functional protein in human parvovirus B19 (genus erythroparvovirus), using an experimentally validated software, Synplot2. Synplot2 detected an open reading frame, X, conserved in all erythroparvoviruses, which overlaps the VP1 capsid gene, and is under highly significant selection pressure. In a related virus, human parvovirus (genus tetraparvovirus), Synplot2 also detected an open reading frame under highly significant selection pressure, ARF1, which overlaps the VP1 gene. X and ARF1 have exactly the same location (both overlap the region of VP1 encoding the phospholipase A2 domain), and encode proteins with similar predicted properties, such as a transmembrane region, strongly suggesting that they are homologous. These findings provide compelling evidence that the X protein must be expressed and functional. It is probably translated either from a polycistronic mRNA by a non-canonical mechanism, or from an unmapped monocistronic mRNA. Finally, we also discovered proteins predicted to be expressed from a frame overlapping VP1 in other species related to parvovirus B19: porcine parvovirus 2 (Z protein) and bovine parvovirus 3 (X-like protein).
Mitogenome Variations in a Global Population of Aspergillus fumigatus
Authors: Thorn Veronica , Xu Jianping
Published: September 2023

Aspergillus fumigatus is a ubiquitous, critical priority human fungal pathogen. Despite its clinical importance, there is limited knowledge regarding the variations of the genome within mitochondria, the powerhouse organelle within eukaryotic cells. In this study, we leveraged publicly available raw, whole genome sequence data from 1939 isolates to investigate the variations in the mitochondrial genomes of A. fumigatus. These isolates were isolated from 22 countries on six continents, as well as from outer space and from within the International Space Station. In total, our analysis revealed 39 mitochondrial single nucleotide polymorphisms (mtSNPs) within this global sample and together, these 39 mtSNPs grouped the 1939 isolates into 79 mitochondrial multilocus genotypes (MLGs). Among the 79 MLGs, 39 were each distributed in at least two countries and 30 were each shared by at least two continents. The two most frequent MLGs were also broadly distributed: MLG11 represented 420 isolates from 11 countries and four continents and while MLG79 represented 418 isolates from 18 countries and five continents, consistent with long-distance dispersals of mitogenomes. Our population genetic analyses of the mtSNPs revealed limited differentiation among continental populations but highly variable genetic differences among national populations, largely due to localized clonal expansions of different MLGs. Phylogenetic analysis and Discriminant Analysis of Principal Components of mtSNPs suggested the presence of at least three mitogenome clusters. Linkage disequilibrium, Index of Association, and phylogenetic incompatibility analyses collectively suggested evidence for mitogenome recombination in natural populations of A. fumigatus. In addition, sequence read depth analyses revealed an average ratio of ~20 mitogenomes per nuclear genome in this global population but the ratios varied among strains within and between certain geographic populations. Together, our results suggest evidence for organelle dynamics, genetic differentiation, recombination, and both widespread and localized clonal expansion of the mitogenomes in the global A. fumigatus population.
Promoted Cellular Immune Responses Due to Positive Effect of CVC1302-Induced Lysosomal Escape in Mice
Authors: Yu Xiaoming , Zhang Yuanyuan , Hou Liting , Qiao Xuwen , Zhang Yuanpeng , Cheng Haiwei , Lu Haiyan , Chen Jin , Du Luping , Zheng Qisheng , Hou Jibo , Tong Guangzhi
Published: September 2023

Here, we found higher percentage of CD8+ T cells in piglets immunized with CVC1302-adjuvanted inactivated FMDV vaccine. We wonder whether promoted cellular immunity induced by CVC1302-adjuvanted inactivated FMDV vaccine due to the promoted antigen cross-presentation efficiency of OVA by DC mainly via the cytosolic pathways, demonstrated by enhanced levels of lysosomal escape of OVA in DC, loaded with OVA and CVC1302. Higher levels of ROS and significant enhanced elevated lysosomal pH in DC facilitated the lysosomal escape of OVA. Significant enhanced CTL activities were observed in mice immunized with OVA-CVC1302. Overall, CVC1302 increased the cross-presentation of exogenous antigens and the cross-priming of CD8+ T cells by alkalizing the lysosomal pH and facilitating the lysosomal escape of antigen. These studies shed new light on the development of immunopotentiators to improve the cellular immunity induced by vaccine.
Quantitative Characteristics and Environmental Interpretation of Vegetation Restoration in Burned Areas of the Dry Valleys of Southwest China
Authors: He Zhixue , Luo Jun , Zhang Bin , Wang Lei , Liu Hui , Ma Xueyang , Yue Tianxiang
Published: September 2023

Fire is a common natural disturbance in forest ecosystems and plays an important role in subsequent vegetation patterns. Based on the spatial sequence method instead of the time successional sequence method, this study selected burned areas in different locations in the Anning River Basin, which contains typical dry valleys. Quadrat surveys and quantitative classification were used to identify the vegetation classification, distribution pattern, and environmental interpretation during the natural restoration process after forest fire. The results showed that: (1) the vegetation community in the early stage of natural recovery after forest fire disturbance could be divided into seven community types, and Quercus guyavaefolia H. Leveille (Qg) was the dominant species in the community; (2) vegetation samples could be divided into five ecological types, and the classification and distribution pattern of community types in this region changed most obviously with altitude; and (3) detrended correspondence analysis could clearly classify vegetation community types, and detrended canonical correspondence analysis could well reveal the relationships between species and environmental factors. This study provides a scientific basis guiding the restoration of ecosystem structural stability and biodiversity in burned areas.
Performance Evaluation Of Clustering Algorithms With Constraints And Parameters
Authors: PRASAD M , T Srikanth
Published: September 2023

Data Extraction is a technique is called as clustering which is used to retrieve data either from the files or data bases or both. This paper focuses on the performance evaluation parameters of the clustering algorithms based on different parameters or conditions or constraints and parameters which are used to perform the clustering process to get the clusters on the data sets. Therefore best clusters are retrieved when best parameters or conditions or constraints or preferences which are applied on the data sources for the clustering process. These parameters or conditions or constraints are opted by the user called as user preferences.
Toxicological Evaluation and Central Nervous System Depressant Activities of Lizard Dung in Wistar Rats
Authors: Jimoh Abdulgafar Olayiwola , Okwor Sydney Chibuzor , Tukur Umar Muhammed , Abubakar Bilyaminu , Hudu Shuaibu Abdullahi , Sani Zuwaira , Mohammed Umar , Haruna Muhammad Sanusi , Adeshina Kehinde Ahmad
Published: September 2023

Though studies have characterized lizard dung as an unconventional psychoactive substance of abuse, this has not been demonstrated in experimental settings. We evaluated the toxicity and CNS activity of lizard dung in Wistar rats. The acute and subacute toxicity studies were conducted via oral and inhalational routes. Classical models of tail suspension, forced swim, elevated plus maze, hole board, and sodium pentobarbital-induced sleeping time tests were adopted and the lizard dung were administered via both routes. No mortality was observed for all doses of the test substance administered via both routes during the toxicity studies. Significant changes in serum urea, creatinine, bilirubin, ALP, ALT and AST were recorded. Mixed inflammatory infiltrates and oedema were observed in the lungs from the group that inhaled 1.0g darkish part of lizard dung. Lizard dung produced marked reduction in the exploratory behaviour. Our findings indicate depression of the CNS.
Recovery of Tropical Forests in Southern Haiti Reflects Shift in Local Governance
Authors: Sylvéus Angelet , Cunha Christhian Santana , Flores Bernardo Monteiro , Jakovac Catarina Conte , Peroni Nivaldo
Published: September 2023

Anthropogenic disturbances interacting with natural disturbances, ecological and socio-economic factors can provoke forest degradation and modulate ecosystem resilience. In Haiti, protected areas recently created to reduce forest loss, require studies about forest dynamics and land use to assure the development of sustainable management policies. We combine field interview with Landsat satellite images of the Macaya National Park collected between 1985 and 2021 to investigate: 1) how much of the original forest area has been converted into agricultural or logged area since 1985; and 2) how do elevation and slope influence the expansion of human-induced land-use changes. Our results indicate an increase of 11.36% in forest cover and a reduction of 75.34% in agriculture class cover, despite the passage of seven hurricanes in the region. Forest recovery was apparently unrelated to elevation and slope, and likely reflected the implementation of new environmental laws and policies with the creation of the Macaya National Park in 1983. Restoration and protection programs contributed to ensure access to financial resources, technical assistance and new technology, thus promoting a shift into a more resilient forest system. This study brings hope for forest conservation in Haiti by showing that positive results can be achieved through inclusive collaboration.
A High-Precision Classification Method for Fish Feeding Behavior Analysis Based on Improved RepVGG
Authors: Yang Pu , Liu Qiang Ye , Li Zhenbo
Published: September 2023

Fish feeding behavior analysis plays a critical role in aquaculture, marine fisheries, and ecological monitoring. At present, the accuracy of current fish feeding behavior analysis is easily affected by the environment, and the hypoxia state in water and high temperature have a huge impact on behavior. In addition, the poor stability, and the speed is affected by the calculation amount of the model, so it cannot be applied to aquaculture ponds. In order to solve the above problems, we propose an improved RepVGG-based method for fish feeding behavior analysis to identify nine behavioral states of fish populations, including hypoxia, hot, and normal states of none, medium, and strong feeding. Firstly, our method adds the identity and residual branches to the block of the VGG network, focusing on the acceleration operation to ensure accuracy. At the same time, the Efficient Channel Attention (ECA) module is added to reduce dimensionality to balance speed and accuracy. To evaluate the effectiveness of the method, it is validated on a constructed fish feeding behavior dataset and compared with a Convolutional Neural Network (CNN) including AlexNet, VGG16, ResNet34, MobileNet V3, and RepVGG. The experimental results show that after 15 epochs of training, the average precision of proposed method reached 97%. Compared with the basic classification algorithm, our method can increase by at least 3% while the inference speed exceeds 85 Frames Per Second (FPS). This study can be integrated into the aquaculture vision system to guide users to plan feeding strategies, and provide new ideas and methods for water quality monitoring.
Effects of S-Adenosylhomocysteine-Hydrolase Down-Regulation on Wnt Signaling Pathway in SW480 Cells
Authors: Pavicic Ivana , Rokic Filip , Vugrek Oliver
Published: September 2023

Disorder of S-adenosylhomocysteine hydrolase (AHCY) activity leads to the potentially lethal rare disease AHCY deficiency, first described in 2004 by Baric and co-workers [1]. In order to shed new light on molecular aspects of the disease, in particular changes at transcriptome level, we enabled knock-down of AHCY expression in model systems such as the colon cancer cell line SW480 to simulate the environment occurring in AHCY deficiency patients. Further, we per-formed deep sequencing of mRNA, followed by differential expression and molecular pathway analysis. Fifteen differentially expressed networks were identified, and interestingly, we found a predicted effect of AHCY down-regulation on the expression of the Lymphoidphoid enhanc-er-binding factor 1 (LEF1) gene, indicating changes in the TCF4/LEF1 complex. LEF1, a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a down-stream mediator of the Wnt/β-catenin signaling pathway [2]. LEF1 is essential in stem cell maintenance, and especially in its role in epithelial-mesenchymal transition (EMT). Western blot analysis of LEF1 protein expression confirmed our transcriptomic data predictions and revealed significantly increased LEF1 protein in AHCY- deficient cells, providing a novel link between AHCY and cancer cell phenotype.
The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors
Authors: Fernandes Lívia da Rocha , Lopes Juliana Romano , Bonjorno Andressa Francielli , Prates João Lucas Bruno , Scarim Cauê Benito , Dos Santos Jean Leandro
Published: September 2023

The effective treatment of human immunodeficiency virus (HIV), also known as acquired immunodeficiency syndrome (AIDS), has transformed a highly lethal disease into a chronic and manageable condition. However, better methods need to be developed for eliminating the virus from reservoirs, enhancing patient access and adherence to therapy, and improving treatment in the long term to reduce adverse effects. From the perspective of drug discovery, one promising strategy is the development of anti-HIV prodrugs. This approach aims to enhance the efficacy and safety of treatment, promoting the development of more appropriate and convenient systems for patients. In this review, we discussed the use of the prodrug approach for HIV antiviral agents and emphasized nucleoside reverse transcriptase inhibitors. We comprehensively described various strategies that are used to enhance factors such as water solubility, bioavailability, pharmacokinetic parameters, permeability across biological membranes, chemical stability, drug delivery to specific sites/organs, and tolerability. These strategies might help researchers conduct better studies in this field. We also reported successful examples from the primary therapeutic classes while discussing the advantages and limitations. In this review, we highlighted the key trends in the application of the prodrug approach for treating HIV/AIDS..
The Comparison of Numerical Simulations of Offshore and Onshore Wind Turbines with Experimental Data. Part II: Steady-State Flows
Authors: AsemanBakhsh Mohammad Ali , Karimi Omid
Published: September 2023

Renewable energy research becomes increasingly necessary as it grows in importance. Wind turbines are an excellent method of harnessing wind energy, which is one of the most important renewable energy sources. In light of the importance of studying wind turbine performance, this study describes the background and principles of wind turbine operation. Computational fluid dynamics (CFD) was used to evaluate the hydrodynamic performance of two types of offshore and onshore wind turbines. Mechanical power and thrust force are calculated using the CFD model for both types of turbines in a steady state based on the number of blades and rotors. The results of three-dimensional simulations are compared with those of experimental testing. Based on the method and assumptions used, the offshore turbine's mechanical torque showed an average deviation of about 4%. Increased wind speed increased mechanical power and thrust, while turbulence caused irregular pressure distributions on surfaces as a result of turbulence intensity. Furthermore, as the free wind speed increases, the blade tip and hub speed will also increase, expanding the vortices created by that flow.
Comparative Transcriptome Analysis of Shiga Toxin-Producing Escherichia coli O157:H7 on Bovine Rectoanal Junction Cells and Human Colonic Epithelial Cells During Initial Adherence
Authors: Edison Lekshmi K. , Kudva Indira T. , Kariyawasam Subhashinie
Published: September 2023

Shiga toxin-producing Escherichia coli (STEC) are notorious foodborne pathogens capable of causing severe diarrhea and other life-threatening complications in humans. Cattle remain a major reservoir and asymptomatic carriers of STEC. In reservoir animals, the rectoanal junction (RAJ) serves as the primary colonization site of STEC playing a critical role in its transmission to humans through contaminated food sources. However, the molecular mechanisms behind the adaptation of STEC in the RAJ of the asymptomatic reservoir host and its subsequent infection of human colonic epithelial cells in an event of a foodborne transmission to cause diarrhea remain largely unexplored. This study aimed to unravel the intricate dynamics of STEC O157:H7 serotype in these two distinct host environments: bovine RAJ cells and human colonic epithelial cells, during initial colonization. In this context, comparative transcriptomics analysis was employed to investigate the differential gene expression profiles of STEC O157:H7 during its interaction with these cell types. The bacterial cells were cultured under controlled conditions to simulate the microenvironments of both bovine RAJ and human colonic epithelial cells. Using high-throughput RNA sequencing, we identified key bacterial genes and regulatory pathways that were significantly modulated in response to each specific host environment. Our findings reveal distinct expression patterns of bacterial genes involved in virulence, including adherence, metal iron homeostasis and stress response in STEC O157:H7 grown in bovine RAJ cells as op-posed to human colonic epithelial cells six hours post-infection. Additionally, the comparative analysis highlights the potential role of certain genes in host adaptation and tissue-specific pathogenicity. Furthermore, this study sheds light on the potential factors contributing to the survival and persistence of STEC O157:H7 in the bovine reservoir, and its ability to colonize in-testinal epithelium and cause disease in humans.
Physical and Biological Stream Health in an Agricultural Watershed
After 30+ Years of Targeted Conservation Practices
Authors: Varela Will L , Mundahl Neal D , Bergen Silas , Staples David F , Cochran-Biederman Jennifer , Weaver Cole
Published: September 2023

Agricultural activities within watersheds can have negative effects on river ecosystems, but numerous conservation practices can be implemented that reduce soil erosion, increase water infiltration, slow runoff, and improve soil quality. Our study focused on analyzing overall stream health (instream and riparian physical, instream biological) at 56 stream sites within an agricultural watershed (83,000 hectares, 70% croplands and rangelands) with a 30+-year history of targeted conservation practices to protect local water resources of importance for tourism and recreation. After implementation of >900 best management practices (BMPs) over the last 20 years in the study subwatersheds, only 20% of the stream sites examined exhibited good stream health and 40% were in poor condition, based on a combination of instream and riparian factors and aquatic community integrity. Time since implementation, location, and total coverage of BMPs within the relatively large subwatersheds all may have contributed to the apparent limited effectiveness of these conservation management practices toward producing observable improvements in stream health to date. Many indicators of stream health (e.g., fine sediments, sediment embeddedness, fish biotic integrity) differed significantly among subwatersheds, but those differences could not be explained by differences in numbers or coverages of BMPs in those subwatersheds. Longitudinal stream health patterns were similar among subwatersheds (moderate health in headwaters, poor in mid-reaches, good in lower reaches), likely due, in part, to similarities in locations of spring discharges and channel instability. New rules protecting stream riparia, maintenance of existing BMPs, and future BMPs targeting remaining problem areas should lead to improving stream health in this large watershed.
Processing Methods of Dried Persimmons
Authors: Hafizov Gharib , Hafizov Samir , Hafizov Rashid
Published: September 2023

A significant increase in persimmon production, combined with a higher percentage of fruits intended for export, led to the need to adapt post-harvest technology to ensure that the fruits reach the end consumer in optimal condition. Persimmon is a climacteric fruit, so the respiratory rate and ethylene production regulate its ripening during storage. Depending on the variety, it can be tart or impatient (initially). During mass harvesting, the pulp of persimmon, regardless of its variety, is usually very hard, but then it softens quickly, which creates problems during transportation. The fruit pulp of tart varieties of persimmon is usually lighter than that of tart varieties, but there are fewer filamentous fibers in the pulp of tart varieties that support its structure, therefore, during post-harvest aging, seedless astringent fruits soften faster than less tart fruits with 1-2 or more seeds. In addition, there are many intermediate varieties that change their food-tasting and technological properties depending on the degree of pollination in a single year. This encourages farmers to adhere to various strategies to reduce post-harvest losses. Persimmons are usually sold fresh or dried in the markets. In this article, we sought to compile an up-to-date and brief overview of the latest achievements in the persimmon drying technique, which may arouse interest among farmers and entrepreneurs seeking to implement their projects in this field of production activity.
The Multifaceted Impact of Green Spaces on Urban Well-being and Sustainability
Authors: verma vishakha
Published: September 2023

The rapid growth of urban areas has led to a decline in the amount of green space available to residents. This has a number of negative consequences for human health and well-- being. Green spaces provide a number of benefits for human health, including improved physical, mental, and social health. They also have a number of economic benefits, such as increased property values and reduced crime rates. Given the many benefits of green spaces, it is clear that they are essential for the health and well-being of urban residents. Policymakers and planners should prioritize the creation and preservation of green spaces in urban areas.
Convergence Analysis of Numerical Solutions of Advection-Diffusion-Reaction Equations Using a Finite Difference Method an Application to Air Pollution Problems
Authors: Sungnul Surattana , Para Kanokwarun , Moore Elvin James , Sirisubtawee Sekson , Phongthanapanich Sutthisak
Published: September 2023

In this paper, we analyze the convergence of a finite difference method with the implicit forward time central space (FTCS) scheme for solving the three-dimensional advection-diffusion-reaction equation (ADRE). It is proved that the method is unconditionally convergent. We apply the scheme to obtain numerical solutions for the transport of pollutants in street tunnel problems with various reaction coefficients and various rates of change of concentrations of sources or sinks of pollution.
Leaflet: Operative Steps for interventional studies
Authors: Meringolo Maria , Delle Monache Sergio , Giuseppina Martella , Peppe Antonella
Published: September 2023

Clinical trials often involve new substances characterized or developed for a specific pathology or class of pathologies. At other times, a clinical trial is observational; in other words, a known substance has a range of effects on a given cohort of subjects. The types of trials are different and complex, and often, the young clinical novice and the inexperienced researcher cannot correctly evaluate how to follow.
In this paper, we want to create a mini guide for beginners in clinical trials and provide elements to design a clinical trial. We intend to point out where to find the materials and how to adjust even in the absence of sponsors so that even the most inexperienced and without means researcher can get an idea of the complexity of the process and deal with it in the right way.
We do not presume to be exhaustive, nor claim to value all the elements, but instead realize a checklist.
With this spirit, starting to talk about the experimental phases of the drug and ending with the clinical trial, we want to help those who face this problematic "world."
STRATEGI MENDAMPINGI DAN MENSTIMULASI DALAM MENINGKATKAN MEMBACA ANAK USIA DINI MELALUI CERGAM (CERITA BERGAMBAR)
Authors: Amalia Dina , Rosdiana Aliva
Published: September 2023

Requirements for entry into primary school are not only based on the age limit of the child, but also on reading requirements. Besides that, the lack of interesting image visualization media makes it seem monotonous and boring for children. The purpose of this dedication to the community is to provide knowledge for teachers and parents at Ilman Nafi' tutoring in Kudus Regency regarding strategies to assist and stimulate early childhood reading. Calistung stands for reading, writing and calculating, these three are basic abilities that a person must possess in order to learn other things more easily. The method of counseling activities starts from event preparation, pre-test before giving material, giving material through power point slides, post-test evaluation, and closing. The instrument in providing material is power point, to carry out the pre-test and post-test using a questionnaire. The output to be achieved is that the teacher and parents make the Cergam (Cerita Bergambar) media and practice and apply it so that they can increase children's interest in reading. The PkM gap analysis is to minimize the need for Calistung through fun reading strategies with Cergam media. The results of the service obtained a pre-test score of 15% and an increase in the post-test score to 100%, the increase in scores from before and after giving the material shows that the counseling has succeeded in increasing knowledge for teachers and parents of Ilman Nafi's tutoring.

 

Abstrak

Persyaratan untuk masuk ke sekolah dasar tidak hanya didasarkan pada batas usia anak, tetapi juga pada persyaratan membaca. Selain itu kurangnya media visualisasi gambar yang menarik sehingga terkesan monoton dan membosankan bagi anak. Tujuan Pengabdian kepada Masyarakat ini untuk memberikan pengetahuan bagi guru dan orang tua di bimbingan belajar Ilman Nafi’ Kabupaten Kudus mengenai strategi mendampingi dan menstimulasi membaca anak usia dini. Calistung adalah singkatan dari membaca, menulis, dan menghitung, ketiganya merupakan kemampuan dasar yang harus dimiliki seseorang agar dapat mempelajari hal lain dengan lebih mudah.  Metode kegiatan penyuluhan mulai dari persiapan acara, pre-test sebelum pemberian materi, pemberian materi melalui slide power point, post-test evaluasi, dan penutupan. Instrumen dalam memberikan materi adalah power point, untuk melakuakan pre-test dan post-test menggunakan angket. Luaran yang ingin dicapai adalah guru dan orang tua membuat media Cergam (Cerita Bergambar) serta mempraktikkan dan menerapkan melalui media Cergam sehingga dapat meningkatkan minat membaca anak. Gap analysis PkM yaitu meminimalisir kebutuhan Calistung melalui strategi membaca menyenangkan berbantu media Cergam. Hasil pengabdian diperoleh nilai pre-test sejumlah 15% dan meningkat pada nilai post-test menjadi 100%, kenaikan nilai dari sebelum dan sesudah pemberian materi menunjukkan bahwa pemberian penyuluhan berhasil menambah pengetahuan bagi guru dan orang tua bimbingan belajar Ilman Nafi’.
On the issue of the effectiveness of the maintenance of insurance medical organizations in the healthcare system of the Russian Federation.
Authors:   Federal State Budgetary Educational Institution of Higher Education «Samara State Medical University» of the Ministry of Health of the Russian Federation, Saraev A. R. , Cherkasov S. N. ,   Federal State Institution of Science Institute of Management Problems them. V. A. Trapeznikov Russian Academy of Sciences, Lukin A. G. ,   Federal State Autonomous Educational Institution of Higher Education «Samara State University of Economics» of the Ministry of Education and Science of the Russian Federation
Published: September 2023

The problems of domestic healthcare are associated with a number of factors that are influenced by the indicators of the economic state of the country, while the main problem is insufficient funding, largely related to the participation of insurance medical organizations in healthcare. A comparison of the cost of maintaining the CFR and the Pension Fund of Russia over a long period of time clearly shows that the effectiveness of the healthcare system with the participation of the CFR is significantly less than the effectiveness of the Pension Fund.
The current state and prospects for the development of rural health care.
Authors:   GBUZ MO MONICA named after M. F. Vladimirsky, Yakushin M.A. , Bakirova E.A. ,   N.A. Semashko National Research Institute of Public Health, Yarotsky S.Yu. ,   N.A. Semashko National Research Institute of Public Health, Vorobieva A.V. ,   N.A. Semashko National Research Institute of Public Health, Vasiliev M.D. ,   N.A. Semashko National Research Institute of Public Health, Gorenkov R.V. ,   GBUZ MO MONICA named after M. F. Vladimirsky
Published: September 2023

The article discusses current trends in the development of primary health care in the Russian Federation. The reasons that caused in the 90s. of the last century, the destruction of rural health care, as well as the effectiveness of restorative measures. A comparative description of the main indicators of the health of rural and urban residents is given. The mortality rate for rural residents is much higher than for urban residents with a steady upward trend. There is a disproportion between the relatively low morbidity rates of the rural population with cardiovascular and oncological pathologies and mortality from the same diseases, which may be due to insufficiently effective detection of these categories of diseases. The concept of a geriatric contact center is proposed, aimed at eliminating the shortage of personnel and resource support for rural healthcare.
Organization of the educational process in improving the primary prevention of non-medical consumption of psychoactive substances by minors.
Authors:   Izhevsk State Medical Academy of the Ministry of Health of Russia, Tikhomirova G.I. , Lukin A.Yu. ,   BUZ UR “Republican Narcological Dispensary of the Ministry of Health of UR”
Published: September 2023

The article presents the results of an experiment conducted in teaching teenagers from among healthy individuals and at-risk groups to prevent the use of psychoactive and other non-drug drugs using a differentiated approach taking into account their metacognitive styles and information coding styles. The main goal of teaching teenagers children was to instill motivation for health-saving behavior as the main meaning of life. After the classes conducted by specially trained personnel from among teachers, narcologists, medical psychologists, nurses with specialized teenagers, positive results were noted in increasing the assessments of hygienic competence of teenagers, their medical activity and motivation to preserve.
A resilient path forward for the Marine Transportation System : recommendations for response and recovery operations from the 2017-2019 hurricane seasons
Authors: Chambers Katherine , Straub Jessamin , Murphy Joshua , Russ Emily ,   U.S. Committee on the Marine Transportation System Resilience Integrated Action Team
Published: September 2023

The Marine Transportation System (MTS), Resilience Integrated Action Team (RIAT), is tasked by the coordinating board of the US Committee on the MTS to serve as a coordinating body to identify the impacts, best practices, and lessons learned by federal agencies involved in the response and recovery of the MTS after hurricane seasons. In response to this request, the RIAT has focused its analysis on the ability of MTS federal agencies to prepare, respond, recover, and adapt to as well as from disruptions. This was accomplished through workshops focused on gathering the collective experiences of emergency response professionals. In 2017, recommendations were gathered based on experiences responding to Hurricanes Harvey, Irma, and Maria. In this report, a similar approach was adopted to gather findings from Hurricanes Florence and Michael in 2018 and Hurricane Dorian in 2019. Utilizing the successes, challenges, and best practices from all six of these storms, the RIAT identified key coordinating bodies and the participants for each and key takeaways relative to the coordination of agencies with respect to the four steps of resilience: prepare, absorb, recover, and adapt.
Optimising global conservation, restoration, and agriculture for people and nature
Authors: Duarte Gabriela , Krieger Joana , Capellão Renata , Lacerda Eduardo , Mortara Sara , Rocha Diogo , Oliveira Luiz Gustavo , Iribarrem Alvaro , Gomes Fernanda , Brooks Thomas , Chaplin-Kramer Rebecca , Enquist Brian , Feng Xiao , Hannah Lee , Hill Samantha , Leclère David , Merow Cory , Obersteiner Michael , Roehrdanz Patrick , Sharp Richard , Watson James , Loyola Rafael , Strassburg Bernardo
Published: September 2023

The Kunming-Montreal Global Biodiversity Framework is a worldwide plan to urgently address and reverse biodiversity loss, intending to achieve a harmonious relationship between humanity and nature by 2050. This paper seeks to contribute to operationalising the framework, specifically concerning biodiversity conservation and nature's contributions to people. Using a global analytical approach, we identify optimised areas for conservation, restoration and agriculture, considering food production, urban expansion, population growth, and climate change projections. By formulating scenarios for increasing natural areas enabled by improvements in agricultural productivity and trade, and considering local and global constraints on restoration actions, we analyse potential outcomes for biodiversity and people. Our findings demonstrate that an optimised spatial allocation of land use could substantially mitigate projected negative impacts and even surpass the current situation, leading to significant socio-environmental gains. However, the best global scenarios for nature and people require integrated planning that considers mitigating climate change, reducing human pressure on natural habitats, increasing trade, and changing human behaviour. Aligning efforts to protect and restore nature with broader sustainability goals through coordinated and transformative action is central to implement the Global Biodiversity Framework and delivery of a more sustainable future.
Box-Behnken design in optimizing heavy metal removal from wastewater using selenium hybridized graphitic carbon nitride nanocomposites
Authors: Mohamed Yasser , Elgohary Elzahraa , Nazer Hossam A. El
Published: September 2023

In this study Box–Behnken designs and response surface methodology (BBD-RSM) was used for optimizing heavy metal adsorption. The hazardous effect of wastewater on agriculture, animals and human as well makes its remediation is being considered a global challenge. Herein, a novel visible-light-responsive selenium-doped graphitic carbon nitride composites via the exfoliation of g-C3N4 polymer with different concentrations of selenium precursor (1w%, 2.5w%, 5w%, with respect to the weight of g-C3N4) under ultrasound irradiation condition to produce the hybridized the corresponding polymeric nanocomposites (5%Se/g-C3N4), (10%Se/g-C3N4) and (25%Se/g-C3N4) denoted names C1, C2, C3; respectively. Full chracterization for the nanocomposites was performed using scanning electron microscope (SEM), X-ray diffraction (XRD), UV-Vis diffuse reflection spectroscopy. The as-prepared nanocomposites compared to pure g-C3N4 were applied in wastewater treatment for a real sample collected from Siwa Lake that suffered from increasing the heavy metal ions due to industrial drainage. Testing the catalytic activity of the prepared composites in treatment of wastewater sample collected from Siwa Lake in Egypt affected by the industrial drainage that was analyzed to determine the occurred polluted heavy metal ions. It was indicated that this sample contained Ca(II), Zn(II), Fe(II), Cu(II), Mn(II) and Cd(II) ions. The metal adsorption measurements were developed using atomic absorption spectroscopy (AAS) to show the removal efficiency of metal ions.
Hybrid DEA-BW-KEMIRA Approach for Multiple Attribute Decision-Making: A Weighted Analysis Perspective
Authors: Soltanifar Mehdi
Published: September 2023

This study presents a novel hybrid approach for Multiple Attribute Decision-Making (MADM), integrating the Data Envelopment Analysis (DEA), Best Worst Method (BWM), and KEmeny Median Indicator Ranks Accordance (KEMIRA) methods. The proposed approach utilizes DEA to streamline the weight selection process in decision-making. By combining BWM and KEMIRA, the hybrid approach improves the accuracy and efficiency of attribute ranking and decision-making. Empirical results demonstrate the effectiveness of the proposed approach in addressing MADM problems with multiple attributes. The weighted analysis perspective provided by this hybrid approach offers valuable insights into decision-making processes, assisting decision makers in making informed choices. This research contributes to the advancement of MADM methodologies and introduces a new approach for handling complex decision scenarios.
PAWS: A Synergy-Based Robotic Quadruped Leveraging Passivity for Robustness and Behavioural Diversity
Authors: Stella Francesco , Achkar Mickael , Santina Cosimo Della , Hughes Josie
Published: September 2023

Quadrupedal animals show remarkable capabilities in traversing diverse terrains and display a range of behaviors and gait patterns. Achieving similar performance is a key goal for robotics researchers. We propose a bio-inspired approach to the design of quadrupeds that seeks to exploit the body and the passive properties of the robot. Using this novel approach we develop \textit{PAWS}, a Passive Automata With Synergies. By leveraging the principles of motor synergies, the design incorporates variable stiffness, biological anatomical insights, and self-organization to simplify control while maximizing its capabilities. The resulting synergy-based quadruped requires only four actuators and exhibits emergent, animal-like dynamical responses, including robustness to environmental perturbations and a wide range of behaviors. The finding contributes to the development of machine intelligence, and provides robots with more efficient and natural-looking robotic locomotion by combining synergistic actuation, compliant body properties, and embodied compensatory strategies.
Theory of resonantly enhanced photo-induced superconductivity
Authors: Michael Marios , Eckhardt Christian , Chattopadhyay Sambuddha , Kennes Dante , Demler Eugene , Sentef Michael
Published: September 2023

Optical driving of materials has emerged as a versatile tool to control their properties, with photo-induced superconductivity being among the most fascinating examples. In this work, we show that light or lattice vibrations coupled to an electronic interband transition naturally give rise to electron-electron
attraction that may be enhanced when the underlying boson is driven into a non-thermal state. We find this phenomenon to be resonantly amplified when tuning the boson’s frequency close to the energy difference between the two electronic bands. This result offers a simple microscopic mechanism for photo-induced superconductivity and provides a recipe for designing new platforms in which light-induced superconductivity can be realized. We propose a concrete setup consisting of a graphene hBN-SrTiO3 heterostructure, for which we estimate a superconducting Tc that may be achieved upon driving the system.