bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Vascular Pericytes and Cytomegalovirus Pathobiology
Authors: Alcendor Donald J.
Published: March 2019

Pericytes are multipotent cells of the vascular system with cytoplasmic extensions proximal to endothelial cells that occur along the abluminal surface of the endothelium. The interactions between endothelial cells and pericytes are essential for proper microvascular formation, development, stabilization, and maintenance. Pericytes are essential for the regulation of paracellular flow between cells, transendothelial fluid transport, angiogenesis, and vascular immunosurveillance. They also influence the chemical composition of the surrounding microenvironment to protect endothelial cells from potential harm. Dysregulation or loss of pericyte function can result in microvascular instability and pathological consequences. Human pericytes have been shown to be targets for human cytomegalovirus (HCMV) infection and lytic replication that likely contribute to vascular inflammation. This review focuses on human vascular pericytes and their permissiveness for HCMV infection. It also discusses their implication in pathogenesis in the blood–brain barrier (BBB), the inner blood–retinal barrier (IBRB), the placenta–blood barrier, and the renal glomerulus as well as their potential role in subclinical vascular disease.
Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review
Authors: Kinoshita Tomonari , Goto Taichiro
Published: March 2019

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and limited to the lungs. Despite the increasing research interest in the pathogenesis of IPF, unfavorable survival rates remain associated with this condition. Recently, novel therapeutic agents have been shown to control the progression of IPF. However, these drugs do not improve lung function and have not been tested prospectively in patients with IPF and coexisting lung cancer, which is a common comorbidity of IPF. Optimal management of patients with IPF and lung cancer requires understanding of pathogenic mechanisms and molecular pathways that are common to both diseases. This review article reflects the current state of knowledge regarding the pathogenesis of pulmonary fibrosis and summarizes the pathways that are common to IPF and lung cancer by focusing on the molecular mechanisms.
Growth and Proliferation of Renal Cell Carcinoma Cells Is Blocked by Low Curcumin Concentrations Combined with Visible Light Irradiation
Authors: Rutz Jochen , Maxeiner Sebastian , Juengel Eva , Bernd August , Kippenberger Stefan , Zöller Nadja , Chun Felix K.-H. , Blaheta Roman A.
Published: March 2019

The anti-cancer properties of curcumin in vitro have been documented. However, its clinical use is limited due to rapid metabolization. Since irradiation of curcumin has been found to increase its anti-cancer effect on several tumor types, this investigation was designed to determine whether irradiation with visible light may enhance the anti-tumor effects of low-dosed curcumin on renal cell carcinoma (RCC) cell growth and proliferation. A498, Caki1, and KTCTL-26 cells were incubated with curcumin (0.1–0.4 µg/mL) and irradiated with 1.65 J/cm2 visible light for 5 min. Controls were exposed to curcumin or light alone or remained untreated. Curcumin plus light, but not curcumin or light exposure alone altered growth, proliferation, and apoptosis of all three RCC tumor cell lines. Cells were arrested in the G0/G1 phase of the cell cycle. Phosphorylated (p) CDK1 and pCDK2, along with their counter-receptors Cyclin B and A decreased, whereas p27 increased. Akt-mTOR-signaling was suppressed, the pro-apoptotic protein Bcl-2 became elevated, and the anti-apoptotic protein Bax diminished. H3 acetylation was elevated when cells were treated with curcumin plus light, pointing to an epigenetic mechanism. The present findings substantiate the potential of combining low curcumin concentrations and light as a new therapeutic concept to increase the efficacy of curcumin in RCC.
Molecular Players of EF-hand Containing Calcium Signaling Event in Plants
Authors: Mohanta Tapan Kumar , Yadav Dhananjay , Khan Abdul Latif , Hashem Abeer , Abd_Allah Elsayed Fathi , Al-Harrasi Ahmed
Published: March 2019

Ca2+ is a universal second messenger that plays a pivotal role in diverse signaling mechanisms in almost all life forms. Since the evolution of life from an aquatic to a terrestrial environment, Ca2+ signaling systems have expanded and diversified enormously. Although there are several Ca2+ sensing molecules found in a cell, EF-hand containing proteins play a principal role in calcium signaling event in plants. The major EF-hand containing proteins are calmodulins (CaMs), calmodulin like proteins (CMLs), calcineurin B-like (CBL) and calcium dependent protein kinases (CDPKs/CPKs). CaMs and CPKs contain calcium binding conserved D-x-D motifs in their EF-hands (one motif in each EF-hand) whereas CMLs contain a D-x3-D motif in the first and second EF-hands that bind the calcium ion. Calcium signaling proteins form a complex interactome network with their target proteins. The CMLs are the most primitive calcium binding proteins. During the course of evolution, CMLs are evolved into CaMs and subsequently the CaMs appear to have merged with protein kinase molecules to give rise to calcium dependent protein kinases with distinct and multiple new functions. Ca2+ signaling molecules have evolved in a lineage specific manner with several of the calcium signaling genes being lost in the monocot lineage.
Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review
Authors: Paskal Adriana , Paskal Wiktor , Pietruski Piotr , Wlodarski Pawel
Published: March 2019

Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that polyethylene glycol (PEG) mediates axolemmal fusion, thus enabling the direct restoration of axon continuity. It also inhibits Wallerian degeneration and recovers nerve conduction. This systemic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, describes and summarizes published studies on PEG treatment efficiency in various nerve injury types and repair techniques. Sixteen original experimental studies in animal models and one in humans were analyzed. PEG treatment superiority was reported in almost all experiments (based on favorable electrophysiological, histological, or behavioral results). To date, only one study attempted to transfer the procedure into the clinical phase. However, some technical aspects, e.g., the maximal delay between trauma and successful treatment, await determination. PEG therapy is a promising prospect that may improve the surgical treatment of peripheral nerve injuries in the clinical practice.
Preliminary Study on Clusterin Protein (sCLU) Expression in PC-12 Cells Overexpressing Wild-Type and Mutated (Swedish) AβPP genes Affected by Non-Steroid Isoprenoids and Water-Soluble Cholesterol
Authors: Pająk Beata , Kania Elżbieta , Gołaszewska Anita , Orzechowski Arkadiusz
Published: March 2019

In this study we attempted to verify the hypothesis that the mevalonate pathway affects amyloid beta precursor protein (AβPP) processing and regulates clusterin protein levels. AβPP expression was monitored by green fluorescence (FL) and Western blot (WB). WB showed soluble amyloid protein precursor alpha (sAβPPα) presence in AβPP-wt cells and Aβ expression in AβPP-sw cells. Nerve growth factor (NGF)-differentiated rat neuronal pheochromocytoma PC-12 cells were untreated/treated with statins alone or together with non-sterol isoprenoids. Co-treatment with mevalonate, dolichol, ubiquinol, farnesol, geranylgeraniol, or water-soluble cholesterol demonstrated statin-dependent neurotoxicity resulted from the attenuated activity of mevalonate pathway rather than lower cholesterol level. Atorvastatin (50 μM) or simvastatin (50 μM) as well as cholesterol chelator methyl-β-cyclodextrin (0.2 mM) diminished cell viability (p < 0.05) and clusterin levels. Interestingly, co-treatment with mevalonate, dolichol, ubiquinol, farnesol, geranylgeraniol, or water-soluble cholesterol stimulated (p < 0.05) clusterin expression. Effects of non-sterol isoprenoids, but not water soluble cholesterol (Chol-PEG), were the most significant in mock-transfected cells. Geranylgeraniol (GGOH) overcame atorvastatin (ATR)-dependent cytotoxicity. This effect does not seem to be dependent on clusterin, as its level became lower after GGOH. The novelty of these findings is that they show that the mevalonate (MEV) pathway rather than cholesterol itself plays an important role in clusterin expression levels. In mock-transfected, rather than in AβPP-overexpressing cells, GGOH/farnesol (FOH) exerted a protective effect. Thus, protein prenylation with GGOH/FOH might play substantial role in neuronal cell survival.
Privacy-Preserving Secure Computation of Skyline Query in Distributed Multi-Party Databases
Authors: Qaosar Mahboob , Zaman Asif , Siddique Md. Anisuzzaman , Annisa  , Morimoto Yasuhiko
Published: March 2019

Selecting representative objects from a large-scale database is an essential task to understand the database. A skyline query is one of the popular methods for selecting representative objects. It retrieves a set of non-dominated objects. In this paper, we consider a distributed algorithm for computing skyline, which is efficient enough to handle “big data”. We have noticed the importance of “big data” and want to use it. On the other hand, we must take care of its privacy. In conventional distributed algorithms for computing a skyline query, we must disclose the sensitive values of each object of a private database to another for comparison. Therefore, the privacy of the objects is not preserved. However, such disclosures of sensitive information in conventional distributed database systems are not allowed in the modern privacy-aware computing environment. Recently several privacy-preserving skyline computation frameworks have been introduced. However, most of them use computationally expensive secure comparison protocol for comparing homomorphically encrypted data. In this work, we propose a novel and efficient approach for computing the skyline in a secure multi-party computing environment without disclosing the individual attributes’ value of the objects. We use a secure multi-party sorting protocol that uses the homomorphic encryption in the semi-honest adversary model for transforming each attribute value of the objects without changing their order on each attribute. To compute skyline we use the order of the objects on each attribute for comparing the dominance relationship among the objects. The security analysis confirms that the proposed framework can achieve multi-party skyline computation without leaking the sensitive attribute value to others. Besides that, our experimental results also validate the effectiveness and scalability of the proposed privacy-preserving skyline computation framework.
Selective Wander Join: Fast Progressive Visualizations for Data Joins
Authors: Procopio Marianne , Scheidegger Carlos , Wu Eugene , Chang Remco
Published: March 2019

Progressive visualization offers a great deal of promise for big data visualization; however, current progressive visualization systems do not allow for continuous interaction. What if users want to see more confident results on a subset of the visualization? This can happen when users are in exploratory analysis mode but want to ask some directed questions of the data as well. In a progressive visualization system, the online aggregation algorithm determines the database sampling rate and resulting convergence rate, not the user. In this paper, we extend a recent method in online aggregation, called Wander Join, that is optimized for queries that join tables, one of the most computationally expensive operations. This extension leverages importance sampling to enable user-driven sampling when data joins are in the query. We applied user interaction techniques that allow the user to view and adjust the convergence rate, providing more transparency and control over the online aggregation process. By leveraging importance sampling, our extension of Wander Join also allows for stratified sampling of groups when there is data distribution skew. We also improve the convergence rate of filtering queries, but with additional overhead costs not needed in the original Wander Join algorithm.
Unusual Behavior of Xylosandrus compactus (Coleoptera: Scolytinae) on Carob Trees in a Mediterranean Environment
Authors: Gugliuzzo Antonio , Criscione Giulio , Tropea Garzia Giovanna
Published: March 2019

Xylosandrus compactus (Eichhoff), commonly known as the black twig borer, was reported in Sicily (Italy) at the end of 2016, infesting Carob tree (Ceratonia siliqua L.) twigs, large branches, and trunks. Previous research indicated that X. compactus attacks only small twigs and branches, not large branches and tree trunks. This unusual behavior was monitored through the two following years in five sites in Ragusa province (Sicily, Italy). For each of the monitored sites, the diameter of the infested trunks and branches was recorded. Samples of branches and trunks presenting galleries were removed from the trees and analyzed in the laboratory. Xylosandrus compactus occurred on branches of all monitored trees, while the percentage of infested trunks of carob trees ranged from 60% to 80%. Inside the infested galleries, all biological stages of X. compactus were found. Infestations were also recorded on trunks and branches with diameters greater than 80 cm and 30 cm, respectively. The mean number of X. compactus specimens inside the galleries was recorded and gallery shape was described. Unordinary behaviors, like the one described here for the first time, can affect the current efficiency of management recommendations.
Wear Behavior of Copper–Graphite Composites Processed by Field-Assisted Hot Pressing
Authors: Liu Qian , Castillo-Rodríguez Miguel , Galisteo Antonio Julio , Guzmán de Villoria Roberto , Torralba José Manuel
Published: March 2019

Copper–graphite composites with 0–4 wt % graphite were fabricated by field-assisted hot pressing with the aim of studying the effect of graphite content on microhardness and tribological properties. Experimental results reveal that hardness decreases with the graphite content. Wear testing was carried out using a ball-on-disc tribometer with a normal load of 8 N at a constant sliding velocity of 0.16 m/s. The friction coefficient of composites decreases significantly from 0.92 to 0.29 with the increase in graphite content, resulting in a friction coefficient for the 4 wt % graphite composite that is 68.5% lower than pure copper. The wear rate first increases when the graphite content is 1 wt %; it then decreases as the graphite content is further increased until a certain critical threshold concentration of graphite, which seems to be around 3 wt %. Plastic deformation in conjunction with some oxidative wear is the wear mechanism observed in pure copper, while abrasive wear is the main wear mechanism in copper–graphite composites.
Preparation and Mechanical Properties of Graphene/Carbon Fiber-Reinforced Hierarchical Polymer Composites
Authors: Vázquez-Moreno Jose M. , Sánchez-Hidalgo Ruben , Sanz-Horcajo Estela , Viña Jaime , Verdejo Raquel , López-Manchado Miguel A.
Published: March 2019

Conventional carbon fiber-reinforced plastics (CFRP) have extensively been used as structural elements in a myriad of sectors due to their superior mechanical properties, low weight and ease of processing. However, the relatively weak compression and interlaminar properties of these composites limit their applications. Interest is, therefore, growing in the development of hierarchical or multiscale composites, in which, a nanoscale filler reinforcement is utilized to alleviate the existing limitations associated with the matrix-dominated properties. In this work, the fabrication and characterization of hierarchical composites are analyzed through the inclusion of graphene to conventional CFRP by vacuum-assisted resin infusion molding.
The Regenerative Applicability of Bioactive Glass and Beta-Tricalcium Phosphate in Bone Tissue Engineering: A Transformation Perspective
Authors: Lowe Baboucarr , Ottensmeyer Mark P. , Xu Chun , He Yan , Ye Qingsong , Troulis Maria J.
Published: March 2019

The conventional applicability of biomaterials in the field of bone tissue engineering takes into consideration several key parameters to achieve desired results for prospective translational use. Hence, several engineering strategies have been developed to model in the regenerative parameters of different forms of biomaterials, including bioactive glass and β-tricalcium phosphate. This review examines the different ways these two materials are transformed and assembled with other regenerative factors to improve their application for bone tissue engineering. We discuss the role of the engineering strategy used and the regenerative responses and mechanisms associated with them.
On Coating Techniques for Surface Protection: A Review
Authors: Fotovvati Behzad , Namdari Navid , Dehghanghadikolaei Amir
Published: March 2019

A wide variety of coating methods and materials are available for different coating applications with a common purpose of protecting a part or structure exposed to mechanical or chemical damage. A benefit of this protective function is to decrease manufacturing cost since fabrication of new parts is not needed. Available coating materials include hard and stiff metallic alloys, ceramics, bio-glasses, polymers, and engineered plastic materials, giving designers a variety freedom of choices for durable protection. To date, numerous processes such as physical/chemical vapor deposition, micro-arc oxidation, sol–gel, thermal spraying, and electrodeposition processes have been introduced and investigated. Although each of these processes provides advantages, there are always drawbacks limiting their application. However, there are many solutions to overcome deficiencies of coating techniques by using the benefits of each process in a multi-method coating. In this article, these coating methods are categorized, and compared. By developing more advanced coating techniques and materials it is possible to enhance the qualities of protection in the future.
Effects of Swell on Wave Height Distribution of Energy-Conserved Bimodal Seas
Authors: Orimoloye Stephen , Karunarathna Harshinie , Reeve Dominic E.
Published: March 2019

An understanding of the wave height distribution of a sea state is important in forecasting extreme wave height and lifetime fatigue predictions of marine structures. In bimodal seas, swell can be present at different percentages and different frequencies while the energy content of the sea state remains unaltered. This computational study investigates how the wave height distribution is affected by different swell percentages and long swell periods in an energy-conserved bimodal sea both near a wave maker and in shallow water. A formulated energy-conserved bimodal spectrum was created from unimodal sea states and converted into random waves time series using the Inverse Fast Fourier Transform (IFFT). The resulting time series was used to drive a Reynolds-Averaged Navier Stokes computational (RANS) model. Wave height values were then extracted from the model results (both away near and near the structure) using down-crossing analysis to inspect the non-linearity imposed by wave-wave interactions and through transformations as they propagate into shallow waters near the structure. It is concluded that the kurtosis and skewness of the wave height distribution very inversely with the swell percentage and peak periods. Non-linearities are greater in the unimodal seas compared to the bimodal seas with the same energy content. Also, non-linearities are greater structure side than at wave maker and are more dependent on the phases of the component waves at different frequencies.
Improved Covariance Matrix Estimation for Portfolio Risk Measurement: A Review
Authors: Sun Ruili , Ma Tiefeng , Liu Shuangzhe , Sathye Milind
Published: March 2019

The literature on portfolio selection and risk measurement has considerably advanced in recent years. The aim of the present paper is to trace the development of the literature and identify areas that require further research. This paper provides a literature review of the characteristics of financial data, commonly used models of portfolio selection, and portfolio risk measurement. In the summary of the characteristics of financial data, we summarize the literature on fat tail and dependence characteristic of financial data. In the portfolio selection model part, we cover three models: mean-variance model, global minimum variance (GMV) model and factor model. In the portfolio risk measurement part, we first classify risk measurement methods into two categories: moment-based risk measurement and moment-based and quantile-based risk measurement. Moment-based risk measurement includes time-varying covariance matrix and shrinkage estimation, while moment-based and quantile-based risk measurement includes semi-variance, VaR and CVaR.
Ecosystem Productivity and Water Stress in Tropical East Africa: A Case Study of the 2010–2011 Drought
Authors: Robinson Eugene S. , Yang Xi , Lee Jung-Eun
Published: March 2019

Characterizing the spatiotemporal patterns of ecosystem responses to drought is important in understanding the impact of water stress on tropical ecosystems and projecting future land cover transitions in the East African tropics. Through the analysis of satellite measurements of solar-induced chlorophyll fluorescence (SIF) and the normalized difference vegetation index (NDVI), soil moisture, rainfall, and reanalysis data, here we characterize the 2010–2011 drought in tropical East Africa. The 2010–2011 drought included the consecutive failure of rainy seasons in October–November–December 2010 and March–April–May 2011 and extended further east and south compared with previous regional droughts. During 2010–2011, SIF, a proxy of ecosystem productivity, showed a concomitant decline (~32% lower gross primary productivity, or GPP, based on an empirical SIF–GPP relationship, as compared to the long-term average) with water stress, expressed by lower precipitation and soil moisture. Both SIF and NDVI showed a negative response to drought, and SIF captured the response to soil moisture with a lag of 16 days, even if it had lower spatial resolution and much smaller energy compared with NDVI, suggesting that SIF can also serve as an early indicator of drought in the future. This work demonstrates the unique characteristics of the 2010–2011 East African drought and the ability of SIF and NDVI to track the levels of water stress during the drought.
Influence of Water on Tribolayer Growth When Lubricating Steel with a Fluorinated Phosphonium Dicyanamide Ionic Liquid
Authors: Urtis Luigi , Arcifa Andrea , Zhang Peng , Du Junxiao , Fantauzzi Marzia , Rauber Daniel , Hempelmann Rolf , Kraus Tobias , Rossi Antonella , Spencer Nicholas
Published: March 2019

This work aims to elucidate the role of environmental humidity on the tribological behavior of steel surfaces lubricated with an ionic liquid comprised of a fluorinated phosphonium cation—tributyl-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-octyl-phosphonium—and a dicyanamide anion (i.e. N(CN)2−). Ball-on-disk tribotests were carried out at room temperature and at various levels of relative humidity (RH). Water was found to be required to promote the formation of a tribofilm over the contact area. The reaction layer exhibited a patchy morphology, which resembles that observed formed with conventional antiwear additives such as ZnDTP. A surface-chemical analysis of the tribofilm indicated that the tribofilm is composed of fluorides, oxides, and phosphates, pointing to a stress-induced degradation of the ions and corrosion of the sliding counterparts, which is enabled by the presence of water at the sliding interface.
Numerical Analysis and Its Laboratory Verification in Bending Test of Glue Laminated Timber Pre-Cracked Beam
Authors: Kawecki Bartosz , Podgórski Jerzy
Published: March 2019

The paper describes an approach to model glue laminated timber (GLT) made of pinewood (softwood), taking into account damage processes in timber and adhesive layers. An example of a pre-cracked beam has been presented. Obtaining necessary material properties has been supported by several finite elements models (FEM), laboratory tests and a wide literature survey. The authors have taken into consideration an orthotropic material with damage for timber lamellas and isotropic traction separation law for bonding layers. Both plane stress CPS8R and COH2D4 finite elements from the Simulia ABAQUS system or mesh density, used in the numerical analyses, have been carefully chosen and tested. The GLT beam model has been verified on the basis of several values, using two types of testing techniques—MTS 809 machine measurements and digital image correlation (DIC). Additional results revision has been provided by measuring a crack shear displacement (CSD), using the original laboratory test setup by the authors’ idea. Finally, some conclusions and introductory recommendations for modelling a glue laminated timber in a plane stress have been formulated. The paper is a part of a wider research on timber-polymer composites, which is still under development.
Non-Destructive Evaluation of Impacted CFRP by IR Thermography
Authors: Swiderski Waldemar , Hlosta Pawel
Published: March 2019

The aim of the article is to present a new technique providing an increase in the reliability of standard destructive tests of light ballistic shields. During the ballistic impact (i.e., of projectiles or fragments) on the material and its penetration by these incoming items, the absorbed kinetic energy is transformed into heat. In particular, the material regions that are damaged generate heat, and around and above the damage, on particular areas of the surface of the sample, the temperature signal increases. While registering, thermal cameras can process the impact and penetration of a material by a projectile and can accurately determine the area of the material (around the point of impact and the area of penetration) that has been damaged. Two infrared cameras were used for our testing work. One recorded the changes to the temperature field on the surface with the ballistic impact and the second one on the opposite surface. These results were compared with those obtained by optical active thermography performed by the reflection approach. Selected results from all the tests are presented in this paper.
Preparation and Physical Properties of High-Belite Sulphoaluminate Cement-Based Foam Concrete Using an Orthogonal Test
Authors: Liu Chao , Luo Jianlin , Li Qiuyi , Gao Song , Jin Zuquan , Li Shaochun , Zhang Peng , Chen Shuaichao
Published: March 2019

Prefabricated building development increasingly requires foam concrete (FC) insulation panels with low dry density (ρd), low thermal conductivity coefficient (kc), and a certain compressive strength (fcu). Here, the foam properties of a composite foaming agent with different dilution ratios were studied first, high-belite sulphoaluminate cement (HBSC)-based FCs (HBFCs) with 16 groups of orthogonal mix proportions were subsequently fabricated by a pre-foaming method, and physical properties (ρd, fcu, and kc) of the cured HBFC were characterized in tandem with microstructures. The optimum mix ratios for ρd, fcu, and kc properties were obtained by the range analysis and variance analysis, and the final optimization verification and economic cost of HBFC was also carried out. Orthogonal results show that foam produced by the foaming agent at a dilution ratio of 1:30 can meet the requirements of foam properties for HBFC, with the 1 h bleeding volume, 1 h settling distance, foamability, and foam density being 65.1 ± 3.5 mL, 8.0 ± 0.4 mm, 27.9 ± 0.9 times, and 45.0 ± 1.4 kg/m3, respectively. The increase of fly ash (FA) and foam dosage can effectively reduce the kc of the cured HBFC, but also leads to the decrease of fcu due to the increase in mean pore size and the connected pore amount, and the decline of pore uniformity and pore wall strength. When the dosage of FA, water, foam, and the naphthalene-based superplasticizer of the binder is 20 wt%, 0.50, 16.5 wt%, and 0.6 wt%, the cured HBFC with ρd of 293.5 ± 4.9 kg/m3, fcu of 0.58 ± 0.02 MPa and kc of 0.09234 ± 0.00142 W/m·k is achieved. In addition, the cost of HBFC is only 39.5 $/m3, which is 5.2 $ lower than that of ordinary Portland cement (OPC)-based FC. If the surface of the optimized HBFC is further treated with water repellent, it will completely meet the requirements for a prefabricated ultra-light insulation panel.
The Effect of Thermal Contact Number on the Tube–Tube Contact Conductance of Single-Walled Carbon Nanotubes
Authors: Yang Xueming , Zhang Xinyao , Cao Bingyang
Published: March 2019

The contact conductance of single, double, and triple thermal contacts of single-walled carbon nanotubes (SWCNTs) was investigated using molecular dynamics simulations. Our results showed that the effect of the thermal contact number on the contact conductance was not as strong as previously reported. The percentages of contact conductance of double and triple thermal contacts were about 72% and 67%, respectively, compared to that of a single thermal contact. Moreover, we found that the contact conductance of the double and triple thermal contacts was associated with the SWCNT length and the positional relationship of the thermal contacts.
Crosstalk Between Mammalian Antiviral Pathways
Authors: Watson Samir F. , Knol Lisanne I. , Witteveldt Jeroen , Macias Sara
Published: March 2019

As part of their innate immune response against viral infections, mammals activate the expression of type I interferons to prevent viral replication and dissemination. An antiviral RNAi-based response can be also activated in mammals, suggesting that several mechanisms can co-occur in the same cell and that these pathways must interact to enable the best antiviral response. Here, we will review how the classical type I interferon response and the recently described antiviral RNAi pathways interact in mammalian cells. Specifically, we will uncover how the small RNA biogenesis pathway, composed by the nucleases Drosha and Dicer can act as direct antiviral factors, and how the type-I interferon response regulates the function of these. We will also describe how the factors involved in small RNA biogenesis and specific small RNAs impact the activation of the type I interferon response and antiviral activity. With this, we aim to expose the complex and intricate network of interactions between the different antiviral pathways in mammals.
Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs
Authors: Biswas Saumik , Chakrabarti Subrata
Published: March 2019

Management of chronic diabetic complications remains a major medical challenge worldwide. One of the characteristic features of all chronic diabetic complications is augmented production of extracellular matrix (ECM) proteins. Such ECM proteins are deposited in all tissues affected by chronic complications, ultimately causing organ damage and dysfunction. A contributing factor to this pathogenetic process is glucose-induced endothelial damage, which involves phenotypic transformation of endothelial cells (ECs). This phenotypic transition of ECs, from a quiescent state to an activated dysfunctional state, can be mediated through alterations in the synthesis of cellular proteins. In this review, we discussed the roles of non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in such processes. We further outlined other epigenetic mechanisms regulating the biogenesis and/or function of non-coding RNAs. Overall, we believe that better understanding of such molecular processes may lead to the development of novel biomarkers and therapeutic strategies in the future.
Correction: Billeaud et al. “Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants” Nutrients 2018, 10, 690
Authors: Billeaud Claude , Boué-Vaysse Carole , Couëdelo Leslie , Steenhout Philippe , Jaeger Jonathan , Cruz-Hernandez Cristina , Ameye Laurent , Rigo Jacques , Picaud Jean-Charles , Saliba Elie , Hays Nicholas P. , Destaillats Frédéric
Published: March 2019

The authors wish to make a correction to the published version of their paper [...]
Modelling the Association between Core and Discretionary Energy Intake in Adults with and without Obesity
Authors: Fong Mackenzie , Li Ang , Hill Andrew J , Cunich Michelle , Skilton Michael R , Madigan Claire D , Caterson Ian D
Published: March 2019

Background: Many dietary recommendations for weight control rely on the assumption that greater core food intake will displace intake of energy-dense discretionary foods and beverages. However, there is little evidence to support these assumptions. This study examined the naturalistic relationship between daily core and discretionary energy intake, and with discretionary food and discretionary beverage intake, separately. The impact of weight status on these associations was also examined. Method: One hundred participants completed a four-day (non-consecutive) estimated food diary. Discretionary foods and beverages were identified by reference to the Australian Dietary Guidelines. Non-discretionary items were considered core items. Simultaneous-equation random effects models using disaggregated dietary data controlling for sociodemographic variables were used to determine the association between various dietary components. Result: Core energy intake correlated negatively with discretionary energy intake (cross-equation correlation, ρ = −0.49 (95% CI: −0.57, −0.39)). Its correlation with discretionary foods (−0.47 (−0.56, −0.37)) was stronger than that with discretionary beverages (−0.19 (−0.30, −0.07)) The correlation between core energy intake and discretionary energy intake was significantly stronger in participants who did not have obesity (−0.67 (−0.71, −0.50)) than those with obesity (−0.32 (−0.46, −0.17)) (p = 0.0002). Conclusions: Core and discretionary energy intake share an inverse and potentially bidirectional, relationship that appears to be stronger with discretionary foods than discretionary beverages. These relationships were significantly weaker in participants with obesity which may indicate less precise dietary compensation in these individuals. While strategies that promote greater intake of core foods may assist with weight maintenance in individuals of healthy weight, its impact in individuals with obesity may be limited. These strategies should be accompanied by direct messages to reduce commensurately the intake of discretionary items, with special attention paid to discretionary beverage consumption.
Validation of Energy and Nutrition Intake in Japanese Elderly Individuals Estimated Based on a Short Food Frequency Questionnaire Compared against a 7-day Dietary Record: The Kyoto-Kameoka Study
Authors: Watanabe Daiki , Nanri Hinako , Yoshida Tsukasa , Yamaguchi Miwa , Sugita Mayu , Nozawa Yoshizu , Okabe Yuki , Itoi Aya , Goto Chiho , Yamada Yosuke , Ishikawa-Takata Kazuko , Kobayashi Hisamine , Kimura Misaka ,   Kyoto-Kameoka Study Group
Published: March 2019

To determine the association between geriatric disorders and dietary intake, validation of a food frequency questionnaire (FFQ) for elderly individuals is needed. We compared energy and nutrient intakes derived from dietary records (DR) and FFQ in an elderly population and compared the data against results from middle-aged individuals (30–68 years) from a previous study. Current participants included 65 women and 78 men (65–88 years) who completed FFQ and 7-day DR in a subpopulation of the Kyoto-Kameoka study. Our FFQ was created for middle-aged individuals. To validate the FFQ, we investigated equivalent precision by comparing the correlation coefficients between the present and previous study. Median correlations for energy and nutrient intake between the DR and FFQ in the current and previous studies were 0.24 and 0.30 (p = 0.329) in women and 0.24 and 0.28 (p = 0.399) in men, respectively. The median ratio of FFQ to DR for these intakes were also similar. The accuracy and precision of the FFQ for energy and nutrient intake in elderly individuals did not differ compared with previous findings in a middle-aged population. A validation study evaluating energy and nutrient intake using recovery biomarkers is further needed.
Are the Motives for Food Choices Different in Orthorexia Nervosa and Healthy Orthorexia?
Authors: Depa Julia , Barrada Juan Ramón , Roncero María
Published: March 2019

Recent research points to the bidimensional nature of orthorexia, with one dimension related to interest in healthy eating (healthy orthorexia) and another dimension related to a pathological preoccupation with eating healthily (orthorexia nervosa). Research was needed to provide further support for this differentiation. We examined the food-choice motives related to both aspects of orthorexia. Participants were 460 students from a Spanish university who completed the Teruel Orthorexia Scale and the Food Choice Questionnaire. By means of structural equation modeling, we analyzed the relationship between orthorexia, food-choice motives, gender, body mass index, and age. The motives predicting food choices in orthorexia nervosa and healthy orthorexia were quite different. In the case of orthorexia nervosa, the main motive was weight control, with sensorial appeal and affect regulation also showing significant associations. For healthy orthorexia, the main motive was health content, with sensorial appeal and price also showing significant associations. This supports the hypothesis that orthorexia nervosa is associated with maladaptive eating behavior motived more by weight control than by health concerns.
Embryology in Helosis cayennensis (Balanophoraceae): Structure of Female Flowers, Fruit, Endosperm and Embryo
Authors: Gonzalez Ana Maria , Sato Héctor A. , Marazzi Brigitte
Published: March 2019

Helosis cayennensis (Balanophoraceae s.str.) is a holoparasite characterised by aberrant vegetative bodies and tiny, reduced unisexual flowers. Here, we analysed the development of female flowers to elucidate their morpho-anatomy and the historical controversy on embryo sac formation. We also studied the developmental origin of inflorescences and the ontogeny of fruits, embryo and endosperm and discussed in a phylogenetic framework. Inflorescences were analysed by optical, fluorescence and scanning electron microscopy. Inflorescences of H. cayennensis arise endogenously. Female flowers lack perianth organs, thus only consist of the ovary, two styles and stigmata. Ovules are undifferentiated; two megaspore mother cells develop inside a nucellar complex. The female gametophyte, named Helosis-type, is a bisporic four-celled embryo sac, provided with a typical egg apparatus and a uni-nucleated central cell. Fertilization was not observed, yet a few-celled embryo and cellular endosperm developed. In sum, results confirm that, among Santalales holoparasites, Helosis is intermediate in the reduction series of its floral organs. Although perianth absence best supports the Balanophoraceae s.str. clade, our literature survey on female flower developmental data across Balanophoraceae s.l. highlights the many gaps that need to be filled to really understand these features in the light of new phylogenetic relationships.
Expression of Genes Related to Sugar and Amino Acid Transport and Cytokinin Metabolism during Leaf Development and Senescence in Pisum sativum L.
Authors: Ninan Annu S. , Grant Jan , Song Jiancheng , Jameson Paula E.
Published: March 2019

Gene editing is becoming the plant breeding tool of choice, but prior to targeting a gene for editing, a knowledge of the gene family members (GFMs) controlling yield is required in the specific crop plant. Critical to yield are components from senescing leaves. We targeted genes controlling senescence in Pisum sativum and the release and transport of carbohydrates and amino acids from the source leaves to the pods and seeds. The expression of GFMs for cytokinin biosynthesis (IPT) and destruction (CKX), sucrose transporters (SUT), Sugar Will Eventually be Exported Transporters (SWEET), amino acid permeases (AAP), and cell wall invertases, was determined using RT-qPCR. GFMs were differentially expressed in leaves of different ages. The expression of many gene family members was lower in the expanding sink leaves compared with the senescing leaves, with the exception of two PsAAP GFMs and PsCKX5, which were highly expressed. Expression of specific PsSWEETs, SUTs, and AAPs increased in the mature and/or senescing leaves. Expression of PsIPTs was least in the mature source leaves, but as strong in the senescing leaves as in the young source leaves. PsCKX7 was expressed in source and senescing leaves. We discuss the potential impact of the targeted reduction of specific PsCKX GFMs on source-sink relationships.
Effect of a Modified Silicone as a Thickener on Rheology of Liquid CO2 and Its Fracturing Capacity
Authors: Li Qiang , Wang Yanling , Wang Fuling , Li Qingchao , Kobina Forson , Bai Hao , Yuan Lin
Published: March 2019

The low viscosity of pure liquid CO2 hindered the development of CO2 fracturing technology. A modified silicone polymer was prepared as a CO2 thickener to investigate the effect of temperature, pressure, shear rate and thickener content (wt.%) on the apparent viscosity and rheology of thickened liquid CO2. In addition, CO2 fracturing capacity was evaluated with the numerical simulation of extended finite element. The results displayed that an apparent viscosity of up to 1.3 mPa·s at 303 K and 18 MPa was attained over liquid CO2 using the thickener of 3 wt.% and Toluene of 9 wt.% as additives. Compared to the commercial linear polydimethylsiloxane, a better apparent viscosity was obtained from the mixture of this prepared thickener, Toluene and CO2. The apparent viscosity decreases with increasing temperature and shear rate. By contrast, an improving apparent viscosity was revealed with an increase in the pressure from 8 to 14 MPa and thickener content from 1 to 3 wt.%. The rheological index decreased with increasing thickener content with pressure but the rise in temperature led to an increasing rheological index. The mesh structure theory of the thickener, CO2 and Toluene molecules was in this paper gives a good explanation for the discrepancy between CO2 viscosity with the thickener content, temperature, pressure, or shear rate. Compared to pure CO2, the numerical simulation of CO2 fracturing demonstrated an excellent fracturing capacity by using the thickened CO2 fracturing fluid in shale reservoirs. This investigation could provide the basic reference for the development of CO2 fracturing technology.
d-, l- and d,l-Tryptophan-Based Polyamidoamino Acids: pH-Dependent Structuring and Fluorescent Properties
Authors: Lazzari Federica , Manfredi Amedea , Alongi Jenny , Marinotto Daniele , Ferruti Paolo , Ranucci Elisabetta
Published: March 2019

Chiral polyamidoamino acids were obtained by polyaddition of N,N’-methylenebisacrylamide with d-, d,l- and l-tryptophan (M-d-Trp, M-d,l-Trp and M-l-Trp). l-tryptophan/glycine copolymers, M-G-l-Trp5, M-G-l-Trp10, M-G-l-Trp20 and M-G-l-Trp40, were prepared from l-tryptophan/glycine mixtures. These polymers were amphoteric, with acid-base properties similar to those of the parent amino acids. The l-tryptophan/glycine copolymers with high glycine content were water soluble in the pH range 2-12. M-G-l-Trp40 showed a solubility gap centred at pH 4.5 and all tryptophan homopolymers were soluble only at pH > 7. Dynamic light scattering measurements performed in their solubility ranges, namely 2-11 M-G-l-Trp5, M-G-l-Trp10 and M-G-l-Trp20 and 7-11 for M-G-l-Trp40, M-d-Trp, M-l-Trp and M-d,l-Trp, showed that the size of all samples did not significantly vary with pH. Both M-l-Trp and M-G-l-Trp copolymers showed pH-dependent circular dichroism spectra in the wavelength interval 200–280 nm, revealing structuring. All samples were fluorescent. Their emission spectra were unstructured and, if normalized for their tryptophan content, almost superimposable at the same pH, providing evidence that only tryptophan governed the photoluminescence properties. Changing pH induced in all cases a slight shift of the emission wavelength maximum ascribed to the modification of the microenvironment surrounding the indole ring induced by different protonation degrees.
Optimizing Polymer Solar Cells Using Non-Halogenated Solvent Blends
Authors: Kocak Guler , Gedefaw Desta , Andersson Mats R.
Published: March 2019

More environmentally friendly polymer solar cells were constructed using a conjugated polymer, poly (2,5-thiophene-alt-4,9-bis(2-hexyldecyl)-4,9-dihydrodithieno[3,2-c:3′,2′h][1,5] naphthyridine-5,10-dione, PTNT, as a donor material in combination with PC71BM as an acceptor in a bulk heterojunction device structure. A non-halogenated processing solvent (o-xylene) and solvent additives that are less harmful to the environment such as 1-methoxynaphthalene (MN) and 1-phenylnaphthalene (PN) were used throughout the study as processing solvents. The most widely used halogenated solvent additives (1,8-diiodooctane (DIO) and 1-chloronaphthalene (CN)) were also used for comparison and to understand the effect of the type of solvent additives on the photovoltaic performances. Atomic force microscopy (AFM) was employed to investigate the surface morphology of the films prepared in the presence of the various additives. The best-performing polymer solar cells provided a high open-circuit voltage of 0.9 V, an efficient fill factor of around 70%, and a highest power conversion efficiency (PCE) of over 6% with the use of the eco-friendlier o-xylene/MN solvent systems. Interestingly, the solvent blend which is less harmful and with low environmental impact gave a 20% rise in PCE as compared to an earlier reported device efficiency that was processed from the chlorinated solvent o-dichlorobenzene (o-DCB).
Construction of Carbon Microspheres-Based Silane Melamine Phosphate Hybrids for Flame Retardant Poly(ethylene Terephthalate)
Authors: Xue Baoxia , Qin Ruihong , Wang Jie , Niu Mei , Yang Yongzhen , Liu Xuguang
Published: March 2019

To improve the flame retardancy and inhibit the smoke of poly(ethylene terephthalate) (PET), carbon microspheres (CMSs)-based melamine phosphate (MP) hybrids (MP-CMSs) were constructed in situ with the introduction of CMSs into the hydrothermal reaction system of MP. The integrated MP-CMSs were modified by 3-Aminopropyltriethoxysilane (APTS) to obtain the silane MP-CMSs (SiMP-CMSs) to strengthen the interface binding between the MP-CMSs and PET matrix. The results showed that the SiMP layer was loaded on the CMSs surface. The addition of only 3% SiMP-CMSs increased the limiting oxygen index (LOI) value of the PET from 21% ± 0.1% to 27.7% ± 0.3%, reaching a V-0 burning rate. The SiMP-CMSs not only reduced heat damage, but also inhibited the smoke release during PET combustion, whereupon the peak heat release rate (pk-HRR) reduced from 513.2 to 221.7 kW/m2, and the smoke parameters (SP) decreased from 229830.2 to 81892.3 kW/kg. The fire performance index (FPI) rose from 0.07 m2s/kW to 0.17 m2s/kW, demonstrating the lower fire risk. The proportion of the flame-retardant mode in the physical barrier, flame inhibition, and char effects were recorded as 44.53%, 19.04%, and 9.04%, respectively.