bluuebunny/crossref_metadata_2025 huggingface dataset:
Supraorbital and mini-pterional keyhole craniotomies for brain tumors: a clinical and anatomical comparison of indications and outcomes in 204 cases
Authors: Avery Michael B. , Mallari Regin Jay , Barkhoudarian Garni , Kelly Daniel F.
Published: November 2021

OBJECTIVE

The authors’ objective was to compare the indications, outcomes, and anatomical limits of supraorbital (SO) and mini-pterional (MP) craniotomies in patients with intra- and extraaxial brain tumors, and to assess approach selection, utility of endoscopy, and surgical field overlap.

METHODS

A retrospective analysis was conducted of all brain tumor patients who underwent an SO or MP approach. The analyzed characteristics included pathology, endoscopy use, extent of resection, length of stay (LOS), and complications. On the basis of preoperative MRI data, tumor heatmaps were constructed to compare surgical access provided by both routes, including coronal projection heatmaps for parasellar tumors.

RESULTS

From 2007 to 2020, 158 patients underwent 173 (84.8%) SO craniotomies and 30 patients underwent 31 (15.2%) MP craniotomies; 71 (34.8%) procedures were reoperations. Of these 204 operations, 110 (63.6%) SO and 21 (67.7%) MP approaches were for extraaxial tumors (meningiomas in 65% and 76.2%, respectively). Gliomas and metastases together represented 84.1% and 70% of intraaxial tumors accessed with SO and MP approaches, respectively. Overall, 56.1% of tumors accessed with the SO approach and 41.9% of those accessed with the MP approach were in the parasellar region. Axial projection heatmaps showed that SO access extended along the entire ipsilateral and medial contralateral anterior cranial fossa, parasellar region, ipsilateral sylvian fissure, medial middle cranial fossa, and anterior midbrain, whereas MP access was limited to the ipsilateral middle cranial fossa, sylvian fissure, lateral parasellar region, and posterior aspect of anterior cranial fossa. Coronal projection heatmaps showed that parasellar access extended further superiorly with the SO approach compared with that of the MP approach. Endoscopy was utilized in 98 (56.6%) SO craniotomies and 7 (22.6%) MP craniotomies, with further tumor resection in 48 (49%) and 5 (71.4%) cases, respectively. Endoscope-assisted tumor removal was clustered in areas that were generally at farther distances from the craniotomy or in angled locations such as the cribriform plate region where microscopic visualization is limited. Gross-total or near-total resection was achieved in 120/173 (69%) SO approaches and 21/31 (68%) MP approaches. Major complications occurred in 11 (6.4%) SO approaches and 1 (3.2%) MP approach (p = 0.49). The median LOS decreased to 2 days in the last 2 years of the study.

CONCLUSIONS

This clinical experience suggests the SO and MP craniotomies are versatile, safe, and complementary approaches for tumors located in the anterior and middle cranial fossae and perisylvian and parasellar regions. The SO route, used in 85% of cases, achieved greater overall reach than the MP route. Both approaches may benefit from expanded visualization with endoscopy.
Influence of dexamethasone on visible 5-ALA fluorescence and quantitative protoporphyrin IX accumulation measured by fluorescence lifetime imaging in glioblastomas: is pretreatment obligatory before fluorescence-guided surgery?
Authors: Wadiura Lisa I. , Reichert David , Sperl Veronika , Lang Alexandra , Kiesel Barbara , Erkkilae Mikael , Wöhrer Adelheid , Furtner Julia , Roetzer Thomas , Leitgeb Rainer , Mischkulnig Mario , Widhalm Georg
Published: November 2021

OBJECTIVE

Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is nowadays widely applied for improved resection of glioblastomas (GBMs). Initially, pretreatment with dexamethasone was considered to be essential for optimal fluorescence effect. However, recent studies reported comparably high rates of visible fluorescence in GBMs despite absence of dexamethasone pretreatment. Recently, the authors proposed fluorescence lifetime imaging (FLIM) for the quantitative analysis of 5-ALA–induced protoporphyrin IX (PpIX) accumulation. The aim of this study was thus to investigate the influence of dexamethasone on visible fluorescence and quantitative PpIX accumulation.

METHODS

The authors prospectively analyzed the presence of visible fluorescence during surgery in a cohort of patients with GBMs. In this study, patients received dexamethasone preoperatively only if clinically indicated. One representative tumor sample was collected from each GBM, and PpIX accumulation was analyzed ex vivo by FLIM. The visible fluorescence status and mean FLIM values were correlated with preoperative intake of dexamethasone.

RESULTS

In total, two subgroups with (n = 27) and without (n = 20) pretreatment with dexamethasone were analyzed. All patients showed visible fluorescence independent from preoperative dexamethasone intake. Furthermore, the authors did not find a statistically significant difference in the mean FLIM values between patients with and without dexamethasone pretreatment (p = 0.097).

CONCLUSIONS

In this first study to date, the authors found no significant influence of dexamethasone pretreatment on either visible 5-ALA fluorescence during GBM surgery or PpIX accumulation based on FLIM. According to these preliminary data, the authors recommend administering dexamethasone prior to fluorescence-guided surgery of GBMs only when clinically indicated.
Stereotactic radiosurgery for glioblastoma considering tumor genetic profiles: an international multicenter study
Authors: Bunevicius Adomas , Pikis Stylianos , Kondziolka Douglas , Patel Dev N. , Bernstein Kenneth , Sulman Erik P. , Lee Cheng-chia , Yang Huai-che , Delabar Violaine , Mathieu David , Cifarelli Christopher P. , Arsanious David E. , Dahshan Basem A. , Weir Joshua S. , Speckter Herwin , Mota Angel , Tripathi Manjul , Kumar Narendra , Warnick Ronald E. , Sheehan Jason P.
Published: November 2021

OBJECTIVE

Molecular profiles, such as isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA methyltransferase (MGMT) methylation status, have important prognostic roles for glioblastoma patients. The authors studied the efficacy and safety of stereotactic radiosurgery (SRS) for glioblastoma patients with consideration of molecular tumor profiles.

METHODS

For this retrospective observational multiinstitutional study, the authors pooled consecutive patients who were treated using SRS for glioblastoma at eight institutions participating in the International Radiosurgery Research Foundation. They evaluated predictors of overall and progression-free survival with consideration of IDH mutation and MGMT methylation status.

RESULTS

Ninety-six patients (median age 56 years) underwent SRS (median dose 15 Gy and median treatment volume 5.53 cm3) at 147 tumor sites (range 1 to 7). The majority of patients underwent prior fractionated radiation therapy (92%) and temozolomide chemotherapy (98%). Most patients were treated at recurrence (85%), and boost SRS was used for 12% of patients. The majority of patients harbored IDH wild-type (82%) and MGMT-methylated (62%) tumors. Molecular data were unavailable for 33 patients. Median survival durations after SRS were similar between patients harboring IDH wild-type tumors and those with IDH mutant tumors (9.0 months vs 11 months, respectively), as well as between those with MGMT-methylated tumors and those with MGMT-unmethylated tumors (9.8 vs. 9.0 months, respectively). Prescription dose > 15 Gy (OR 0.367, 95% CI 0.190–0.709, p = 0.003) and treatment volume > 5 cm3 (OR 1.036, 95% CI 1.007–1.065, p = 0.014) predicted overall survival after controlling for age and IDH status. Treatment volume > 5 cm3 (OR 2.215, 95% CI 1.159–4.234, p = 0.02) and absence of gross-total resection (OR 0.403, 95% CI 0.208–0.781, p = 0.007) were associated with inferior local control of SRS-treated lesions in multivariate models. Nine patients experienced adverse radiation events after SRS, and 7 patients developed radiation necrosis at 59 to 395 days after SRS.

CONCLUSIONS

Post-SRS survival was similar as a function of IDH mutation and MGMT promoter methylation status, suggesting that molecular profiles of glioblastoma should be considered when selecting candidates for SRS. SRS prescription dose > 15 Gy and treatment volume ≤ 5 cm3 were associated with longer survival, independent of age and IDH status. Prior gross-total resection and smaller treatment volume were associated with superior local control.
Spinal anesthesia in contemporary and complex lumbar spine surgery: experience with 343 cases
Authors: Breton Jeffrey M. , Ludwig Calvin G. , Yang Michael J. , Nail T. Jayde , Riesenburger Ron I. , Liu Penny , Kryzanski James T
Published: November 2021

OBJECTIVE

Spinal anesthesia (SA) is an alternative to general anesthesia (GA) for lumbar spine surgery, including complex instrumented fusion, although there are relatively few outcome data available. The authors discuss their experience using SA in a modern complex lumbar spine surgery practice to describe its utility and implementation.

METHODS

Data from patients receiving SA for lumbar spine surgery by one surgeon from March 2017 to December 2020 were collected via a retrospective chart review. Cases were divided into nonfusion and fusion procedure categories and analyzed for demographics and baseline medical status; pre-, intra-, and postoperative events; hospital course, including Acute Pain Service (APS) consults; and follow-up visit outcome data.

RESULTS

A total of 345 consecutive lumbar spine procedures were found, with 343 records complete for analysis, including 181 fusion and 162 nonfusion procedures and spinal levels from T11 through S1. The fusion group was significantly older (mean age 65.9 ± 12.4 vs 59.5 ± 15.4 years, p < 0.001) and had a significantly higher proportion of patients with American Society of Anesthesiologists (ASA) Physical Status Classification class III (p = 0.009) than the nonfusion group. There were no intraoperative conversions to GA, with infrequent need for a second dose of SA preoperatively (2.9%, 10/343) and rare preoperative conversion to GA (0.6%, 2/343) across fusion and nonfusion groups. Rates of complications during hospitalization were comparable to those seen in the literature. The APS was consulted for 2.9% (10/343) of procedures. An algorithm for the integration of SA into a lumbar spine surgery practice, from surgical and anesthetic perspectives, is also offered.

CONCLUSIONS

SA is a viable, safe, and effective option for lumbar spine surgery across a wide range of age and health statuses, particularly in older patients and those who want to avoid GA. The authors’ protocol, based in part on the largest set of data currently available describing complex instrumented fusion surgeries of the lumbar spine completed under SA, presents guidance and best practices to integrate SA into contemporary lumbar spine practices.
PENGARUH APLIKASI FITOHORMON TERHADAP PERKECAMBAHAN BENIH GAHARU (Gyrinops versteegii) PASCA PROSES PENYIMPANAN
Authors: Wahid Sarowan , Wangiyana I Gde Adi Suryawan
Published: November 2021

The purpose of this research was to examine the effect of phytohormone and its concentration on germination of 1-week storage G. versteegii’s seeds. Factorial Completely Randomize Design was used with two factors: type of phytohormone (J1:Atonik, J2:gibberellic acid) and phytohormone concentration (K1:200ppm, K2:400ppm). ANOVA shows that phytohormone concentration was the only factor that has a significant difference at α=0.05. Four hundred ppm was an ideal concentration that supports G. versteegii’s seed's better germination rate on atonic and gibberellic acid. However, gibberellic acid has supported a better germination rate than atonic at 400 ppm concentration. It is concluded that gibberellic acid at 400 ppm concentration is the best treatment for G. versteegii germination.
PERUBAHAN SIFAT FISIK DAN CITA RASA KOPI ARABIKA ASAL BONDOWOSO PADA BERBAGAI TINGKAT PENYANGRAIAN
Authors: Suud Hasbi Mubarak , Savitri Dyah Ayu , Ismaya Safa Rajni
Published: November 2021

Arabica coffee from the plantation on the foothill of Ijen-Raung mountains in Bondowoso is well known for its Java Arabica Coffee specialty. The exploration to strengthen the specialty identity is keep going on. This study aims to determine the changes in physical properties and flavor of that arabica coffee during roasting at various times and temperatures of roasting. The aspects of physical properties that were studied include weight to volume ratio, coffee bean dimension, and a color index of RGB (red green blue). The weight-to-volume ratio and color index of RGB decreased as the time and temperature roasting increased. The change in dimension of the coffee bean was caused by roasting also detected, but not dominant signifies the roasting level. This is due to the dimension change of coffee bean in each roasting profile having tiny differences and the dimension of the green bean had high variation. Based on this study, it is known that the roasting with a maximum temperature of 165°C and total time process of 9.5 minutes gives the highest total score of aroma, flavor, acidity, and aftertaste of that arabica coffee.
Combinación de Clozapina + Aripiprazol en esquizofrenia de inicio muy precoz resistente. A propósito de un caso
Authors: Osorio Ángela , Antúnez María B. , Hernando Segura R. , Gordo Seco R.
Published: November 2021

La Esquizofrenia de Inicio Precoz es un cuadro infrecuente pero muy grave, que requiere de la instauración temprana de un tratamiento eficaz. La Clozapina es el estándar en el tratamiento de la psicosis refractaria y su eficacia en niños y en adolescentes es similar a la de los adultos, aunque esta población tiene más riesgo de sufrir efectos adversos potencialmente graves que comprometan su funcionamiento y calidad de vida. Una estrategia para sortear estos inconvenientes habitualmente utilizada en la práctica clínica,  es la combinación de antipsicóticos que se sustenta en que al disminuir la dosis de los fármacos respecto a la monoterapia se disminuyen los efectos adversos que se producen a dosis más altas. Presentamos el caso de un paciente varón, de 13 años, diagnosticado de Esquizofrenia Paranoide de Inicio Muy Precoz, resistente a tratamiento, en el que se utilizó la combinación de Clozapina+Aripiprazol con buenos resultados a nivel de eficacia y tolerancia. El paciente presentaba, además, sintomatología obsesivo-compulsiva que se relacionó con la Clozapina, que remitió tras la adición al tratamiento de Aripiprazol.
URGENSI PEMBENTUKAN PERATURAN DAERAH DI ERA OTONOMI DAERAH
Authors: Lesmana Indra
Published: November 2021

Pelaksanaan desentralisasi dalam negara kesatuan berarti memberikan hak untuk mengatur dan mengurus kepentingan dan aspirasi masyarakat setempat pembentukan daerah otonom dan penyerahan kewenangan secara hukum dari pemerintah pusat ke pemerintah daerah untuk mengatur, mengurus dan/atau bagian dari urusan pemerintahan tertentu. Untuk itu daerah otonom diberikan kewenangan untuk membentuk peraturan daerah. Penelitian ini merupakan penelitian hukum normatif yang membahas tentang urgensi pembentukan peraturan daerah pada era otonomi daerah ialah sebagai rule dari pelaksanaan otonomi daerah, utamanya menyangkut urusan-urusan pemerintahan sebagaimana dimaksud pada Undang-Undang Pemerintahan Daerah dan Peraturan Pemerintah Nomor 38 Tahun Tahun 2007 tentang Pembagian Urusan Pemerintahan antara Pemerintah, Pemerintahan daerah Provinsi, dan Pemerintahan Daerah Kabupaten/Kota. Serta konsep ideal peraturan daerah pada era otonomi daerah dikembalikan kepada asas formil dan materil pembentukan peraturan perundang-undangan sebagaimana termuat didalam Undang-Undang Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan.

URGENCE FOR ESTABLISHING REGIONAL REGULATIONS IN THE ERA REGIONAL AUTONOMY

The implementation of decentralization in a unitary state means giving the right to regulate and manage the interests and aspirations of the local community, the formation of an autonomous region and the delegation of legal authority from the central government to the regional government to regulate, manage and/or part of certain government affairs. For this reason, autonomous regions are given the authority to form regional regulations. This research is a normative legal research that discusses the urgency of the formation of regional regulations in the era of regional autonomy, namely as a rule for the implementation of regional autonomy, especially regarding government affairs as referred to in the Regional Government Law and Government Regulation Number 38 of 2007 concerning Division of Affairs. Government between the Government, Provincial Government, and Regency/City Regional Government. And the ideal concept of regional regulations in the era of regional autonomy was returned to the formal and material principles of the formation of laws and regulations as contained in Law Number 12 of 2011 concerning the Establishment of Legislations.
KONSEP PERLINDUNGAN PACU JALUR KABUPATEN KUANTAN SINGINGI
Authors: Tiaraputri Adi , Diana Ledy
Published: November 2021

Pacu jalur merupakan salah satu tradisi dari Kabupaten Kuantan Singingi Provinsi Riau. Pacu jalur juga termasuk dalam ruang lingkup kebudayaan. Untuk ada kelestarian kebudayaan tentunya harus ada perlindungan terhadap kebudyaan tersebut. Tulisan ini mengkali terkat konsep perlindungan yang dapat diberikan pada tradisi pacu jalur. Metode penelitian dalam tulisan ini melalui pendekatan yuridis normatif.  Dalam tulisan ini mengkaji konsep perlindungan untuk pacu jalur dapat melalui perlindungan warisan budaya tak benda dan kekayaan intelektual komunal.

Pacu Jalur is one of the traditions of Kuantan Singingi Regency, Riau Province. Pacu jalur is also included in the scope of culture. For there to be preservation of culture, of course, there must be protection of that culture. This paper examines the concept of protection that can be given to the tradition of racing lanes. The research method in this paper is through a normative juridical approach. In this paper, we examine the concept of protection for the runway through the protection of intangible cultural heritage and communal intellectual property.
PEMERIKSAAN SAKSI DALAM PERKARA PIDANA BERDASARKAN IUS CONTITUM INDONESIA
Authors: Parlindungan S Toni
Published: November 2021

Proses pemeriksaan saksi dimulai dari penyidikan sampai pada tingkat penuntutan di pengadilan. Di tingkat penyidikan maka terlebih dahulu saksi diperiksa oleh penyidik dengan memperhatikan perlindungan terhadap saksi yaitu tanpa ancaman atau tekanan.dari pihak manapun. Kemudian saksi dapat diperiksa di tempat kediaman saksi dan saksi diperiksa tanpa disumpah. Sedangkan pada tingkat penuntutan atau pesidangan maka terlebih dahulu saksi dipanggil untuk didengar keterangannya. Penelitian ini bertujuan untuk memenuhi kebutuhan terhadap objek penulisan atau suatu karya ilmiah guna mendapatkan data-data, pokok-pokok pikiran, serta pendapat lainnya dari pakar atau media apapun, yaitu terkait pemeriksaan saksi dalam perkara pidana berdasarkan ius contitum indonesia. Dalam penelitian ini penulis menggunakan metode penelitian hukum normative.

 

Abstract

The process of examining witnesses starts from the investigation to the level of prosecution in court. At the level of investigation, the investigator first examines witnesses by paying attention to the protection of witnesses, namely without threats or pressure from any party. Then the witness can be examined at the witness' residence and the witness can be examined without being sworn in. Meanwhile, at the level of prosecution or trial, witnesses are first called to be heard. This study aims to meet the need for the object of writing or a scientific work in order to obtain data, main ideas, and other opinions from experts or any media, which is related to the examination of witnesses in criminal cases based on ius contitum indonesia. This research the authors use normative legal research methods
ANALISIS YURIDIS KEDUDUKAN SURAT PERNYATAAN SETOR MODAL SEBAGAI PENGGANTI BUKTI SETOR MODAL DALAM PENDIRIAN PERSEROAN TERBATAS DI INDONESIA
Authors: Oktavia Dewi , Svinarky Irene
Published: November 2021

Penelitian ini menjelaskan bahwa pada Pasal 32 Ayat (1) Undang-Undang Nomor 40 Tahun 2007 tentang Perseroan Terbatas disebutkan bahwa modal dasar pendirian Perseroan Terbatas paling sedikit berjumlah Rp50.000.000,. Namun jumlah tersebut menyulitkan bagi pelaku Usaha Mikro, Kecil, dan Menengah (UMKM), khususnya usaha mikro. Oleh karena itu, dalam Peraturan Menteri Hukum dan Hak Asasi Manusia Nomor 4 Tahun 2014 kemudian mempermudah pendirian Perseroan Terbatas dengan pendiri hanya membuat Surat Pernyataan Telah Menyetor Modal tanpa harus menyetorkan modalnya. Mengingat penyetoran modal pendirian Perseroan Terbatas merupakan kewajiban yang mutlak yang harus dipenuhi oleh siapapun yang telah menyetujui penempatan modalnya pada Perseroan Terbatas dalam suatu dokumen resmi, baik yang dilakukan sebelum maupun setelah Perseroan Terbatas berdiri dan memperoleh status sebagai badan hukum, maka ketiadaan penyetoran modal pada saat yang telah ditentukan dapat melahirkan perikatan utang-piutang antara Perseroan Terbatas sebagai kreditur dengan pemegang saham sebagai debitur. Metode yang digunakan dalam penelitian ini adalah penelitian hukum normatif.

Abstract

This research explain that Article 32 Paragraph (1) of Law Number 40 of 2007 concerning Limited Liability Companies states that the authorized capital for the establishment of a Limited Liability Company is at least IDR 50,000,000,. However this number makes it difficult for Micro, Small and Medium Enterprises (MSMEs), especially micro businesses. Therefore, in the Regulation of the Minister of Law and Human Rights Number 4 of 2014 then it makes it easier for the establishment of a Limited Liability Company with the founders only to make a Statement of Having Paid Capital without having to deposit their capital. Considering that the payment of capital for the establishment of a Limited Liability Company is an absolute obligation that must be fulfilled by anyone who has approved the placement of their capital in a Limited Liability Company in an official document, either before or after the Limited Liability Company has been established and obtained its status as a legal entity, there is no capital injection at the time. which has been determined can give birth to a debt-receivable agreement between the Limited Liability Company as a creditor and the shareholders as the debtor. . The method used in this research is normative legal research.
Determination of honey quality in the context of physico-chemical and microbiological data in Bosnia and Herzegovina
Authors: Landeka Viktor , Kurtagić Harun , Pažin Jovica , Sarić Edita
Published: November 2021

The aim of this study was to examine the correlation of the obtained results and the overall quality of honey by testing some physico-chemical and
microbiological parameters of honey quality. The quality of honey is determined by it’s organoleptic, biological, physicochemical and microbiological
properties. The purpose of this study was to evaluate the relationship between physico-chemical properties and microbiological properties and for
the purpose of determining honey quality.
Samples were submitted by honey producers in Bosnia and Herzegovina (B&H) in 2018. A total of 14 samples of various categories of honey
from different geographical areas of B&H were taken for testing. Microbiological analysis was performed for recommended microorganisms:
aerobic mesophilic bacteria, bacteria from the family Enterobacteriaceae, sulfite-reducing clostridia and yeasts and molds from the guidelines
for microbiological criteria for food in B&H (FSA B&H 2013), which is adapted to EU regulations. Of the total number of samples examined,
all complied with the regulations. In 50% of the examined honeys, the presence of predominant microorganisms within the permissible deviation
was recorded. The presence of yeasts and molds was found in 35% of honey samples at a concentration of 10 to 100 cfu/g, while the presence of
aerobic mesophilic bacteria was recorded in 15% of the sample over a concentration of 100 cfu/g and in them 15% at a concentration of 10 to 100
cfu/g, Enterobacteriaceae and sulfito-reducing clostridia were not isolated and counted. From the physico-chemical parameters, the following were
examined: the content of reducing sugars, sucrose and total sugars, electrical conductivity, the content of mineral substances, the content of free
acids and the content of moisture (dry matter). All physico-chemical parameters are in accordance with the required quality of the Rulebook on
honey quality (Official Gazette of B&H, 37/09).
Given the very diverse complexity of honey composition, it is very difficult to say the actual source of microbiological activity of the honey samples
tested in this study. Considering that the parameters of possible antimicrobial activity have not been examined and considering the obtained results,
it is not possible to say with certainty whether and which of the tested physicochemical parameters affects the total microbiological activity of honey.
The microbiological presence in the samples indicates the necessity of production, handling and storage of honey, according to the rules of good
hygienic practice.
The assesement of bioactive potential and sensory acceptability of coffee and its byproducts- cascara and silverskin
Authors: Mandura Ana , Cazalens Evan , Komes Draženka , Vojvodić Cebin Aleksandra , Pudić Robert , Šeremet Danijela , Natucci Pasquino Marion
Published: November 2021

Through the decades, coffee has been representing one of the most consumed beverages worldwide and consequently, during the coffee cherry
processing, significant amount of coffee byproducts is generating, thus ending as an agro- industrial waste. Besides macro and micronutrient
content, coffee cascara and coffee silverskin are coffee by-products which can have valuable bioactive potential. For that purpose, ethanol extracts
and water infusions (beverages) of green coffee, roasted coffee, coffee cascara and coffee silverskin were analysed for total phenolic content,
antioxidant capacity and individual identification of polyphenolic compounds by High Performance Liquid Chromatography Analysis paired with
Photo-Diode Array detector (HPLC- PDA), with further sensory analysis of beverages. Results showed that beverages were generally evaluated with
the higher bioactive potential than ethanol extracts, while roasted coffee beverages exhibited the highest content of TPC and antioxidant capacity
in comparison to the ethanol extract. Among all samples, green coffee beverage was evaluated as the most valuable source of 5-caffeoylquinic
acid (36.7 mg/g dw), while coffee cascara (9.2 mg/g dw) contained the highest content of caffeine. Although roasted beverage expectedly scored as
the highest acceptable (6.2), silverskin and cascara were evaluated with relatively satisfactory results of the overall acceptability (4.6- 5.2), thus
showing the potential for the improvement in terms of preparation and, furthermore, greater consumer acceptance.
Клініко-лабораторні та генетичні паралелі у хворих з гетеро- та гомозиготними сімейними гіперхолестеринеміями в Україні
Authors: Mitchenko O. I. , Romanov V. Y. , Vakaluk I. P. , Isayeva A. S. , Rudenko L. V. , Chulaevska N. M. , Timokhova K. O. , Chulaievska I. V.
Published: November 2021

The aim – clinical, laboratory and genetic parallels of patients with hetero- and homozygous familial hypercholesterolemia (FH) in Ukraine.Materials and methods. 231 FH patients were included in the Ukrainian FH Registry: 8 children (under 18 years of age) and 223 adult patients (197 heterozygous FH (HeFH) patients, 26 homozygous FH (HoFH) patients, verified according to DLCN criteria). The patients underwent general clinical, laboratory, instrumental examinations and genetic testing.Results and discussion. Among HeFH patients against the background of early manifestation of atherosclerosis, the male patients were more likely to have coronary heart disease and peripheral atherosclerosis, xanthomatosis and higher DLCN scores against an increase in % obesity and hypertension among HeFH women on the background of significantly lower DLCN. In the HoFH patients despite the inclusion of mostly reproductive aged females in the Registry, it is among women the most severe variants of FH were registered. They were characterized by a predominance of coronary heart disease, MI, xanthomatosis, the need for myocardial revascularization and prosthetic heart valves on the background of higher DLCN scores, cholesterol, LDL-C and ApoB values ​​up to 1.7±0.2 g/L and Lp (a) up to 119.5±31.4 nmol/L. In HoF patients and the most severe variants of the clinical course, who had levels of «statin naive» cholesterol and LDL above 20 mmol/L a more significant increase in these values were found: ApoB average 3.2±1.1 (maximum – 4.72) g/L and Lp (a) to 121.5±41.5 (maximum – 163) nmol/L and reduction of apoA1 level to 0.9±0.1 g/L.Conclusions. HeFH patients retain gender features of the risk factors profile, which corresponds to the main gender-related trends revealed by the Ukrainian population study with a predominance of coronary heart disease, peripheral atherosclerosis and xanthomatosis on the background of higher scores on DLCN in men. HoFH patients showed a reverse trend, namely among women – the predominance of coronary heart disease, myocardial infarction, xanthomatosis and the need for revascularization on the background of a higher score on DLCN. The cohort of HoFH women revealed the most severe FH cases with LDL-C > 20 mmol/L, which was accompanied in 100 % of cases by early development of coronary heart disease and the need for myocardial revascularization, despite young age (36.5±3.9) and preserved reproductive function. According to HoFH patients genetic testing, pathogenetic mutations were detected in 72.3 % of women and 55.5 % of men (92.3 % in LDLR and 7.7 % in apoB). In the cohort of the most severe patients with LDL and LDL cholesterol > 20 mmol/L, genetic mutations were detected in 100 %
Significado de estar sano, enfermedad y curación para los sobanderos indígenas del departamento de Nariño
Authors: Aldair Ezequiel Andrade-Burgos  , Karen Dayana Coral-Cepeda  , Ernesto José Córdoba-Arteaga  , Eunice Yarce-Pinzón  , Jonathan Adrián Muñoz-Luna
Published: November 2021

Introducción: Estudio que tuvo por objetivo comprender los significados de estar sano, enfermedad y curación de lesiones musculares y esqueléticas para los sobanderos del resguardo indígena Quillasinga “Refugio del Sol”. Se realizó un estudio cualitativo fenomenológico, aplicando un instrumento de recolección de información con entrevista semiestructurada de 14 preguntas, dirigidas a 4 sobanderos de la comunidad Quillasinga. Desarrollo: Para los sobanderos el significado de salud, enfermedad y curación tiene múltiples definiciones, que dependen de diferentes factores que influye en la interpretación de este conocimiento, como la cultura, el entorno y, sobre todo, la cosmovisión que tenga cada población. Conclusiones: Cabe resaltar que, desde la cosmovisión indígena, se entiende por curación: una tradición enfocada al tratamiento de lesiones musculares y esqueléticas, que utilizan diferentes métodos ancestrales, convirtiendo su práctica terapéutica en una manera de curación holística e integral, que beneficia a todo aquel que acuda a ellos; enfermedad: la desconexión del cuerpo con el plano astral, compuesto por diferentes creencias espirituales que conforman el aura de una persona (espíritu), como también el consumo permanente de alimentos cultivados con químicos, que contribuyen a la pérdida de la energía positiva del cuerpo. Finalmente, se puede decir que todas sus prácticas tradicionales se fundamentan en el aprendizaje empírico que hace parte de una cascada generacional.
Korespondencija Vladimira Ćopića s Isom Kršnjavim
Authors: Matković Stjepan
Published: November 2021

Članak donosi korespondenciju koju je Vladimir Ćopić upućivao Isidoru Kršnjavomu od 1912. do 1923. godine. Uvodni dio teksta donosi pregled biografskih podataka. U fokusu se nalazi Ćopićeva pripadnost mladohrvatskomu pokretu koji je Kršnjavi podupirao. Isto tako ukazuje se da je Ćopić kao student uživao naklonost staroga Profesora. Najveći broj priloga odnosi se na Ćopićevo javljanje iz ruskoga zarobljeništva tijekom Prvoga svjetskog rata. U njima se očituje njegovo raspoloženje i opisuju ponovni susreti s predratnim suradnicima koji su također bili zarobljeni na različitim bojištima. Korespondencija pokazuje da ni Ćopićevo pristajanje uz boljševizam nije narušilo prijateljstvo i njegovo poštovanje prema staromu Kršnjavome.
Ogrizovićev Dioklecijan – realnost ili fikcija?
Authors: Cambi Nenad
Published: November 2021

Milan Ogrizović napisao je u povodu proslave 1600. obljetnice Milanskog edikta dramu Car Dioklecijan, koju je inscenirao u posebno napisanom epilogu Smrt cara Dioklecijana, izvedenom u Peristilu Dioklecijanove palače u Splitu 28. listopada 1913. godine. Glavni lik drame je car Dioklecijan, koji je u historijskim vrelima predstavljen kao nepomirljivi neprijatelj kršćanstva. Dokazujući tezu o velikom caru kao progonitelju kršćana, Ogrizović se referira i na neke historijski nepotvrđene događaje iz njegova života. Autor članka pronalazi i kritički komentira niz sadržajnih i kronoloških nepodudarnosti između autentičnih historijskih vrela i sadržaja drame. Zaključuje da se Ogrizović postavio slobodno u odnosu na povijesne činjenice, držeći da je kao književnik imao pravo na svoju umjetničku slobodu.
A ê hoĉu kako mogu – nekoliko misli o hrvatskoglagoljskoj pisanoj baštini
Authors: Dürrigl Marija-Ana
Published: November 2021

U radu se ukratko, na temelju nekoliko tipičnih iskaza glagoljaških pisara, kompilatora i prevoditelja, sažimlju neki pogledi na glagoljsku tekstnu zajednicu. Kroz odabrane se citate otkriva povezanost raznorodnoga sadržaja rukopisa (a neki od njih slagani su po idealu "što općenitijega" materijala, kao da se stremilo kakovu srednjovjekovnom enciklopedizmu, čemu je najbliže Petrisov zbornik iz 1468. godine) s konkretnim okruženjem, odnosno publikom za koju su tekstovi pisani, te s polifunkcionalnošću velikoga broja prepisanih, prevedenih ili kompiliranih sastava. To je postupak kroz koji je ostvaren specifičan fenomen "migracije", pokretljivosti i prilagođavanja raznih predložaka i izvora, čime su glagoljaši hrvatsku glagoljsku pisanu riječ učinili dijelom zajedničke europske srednjovjekovne kulturne, duhovne i književne tradicije.
Fast threshold ECDSA with honest majority1
Authors: Damgård Ivan , Jakobsen Thomas P. , Nielsen Jesper Buus , Pagter Jakob Illeborg , Østergaard Michael Bæksvang
Published: November 2021

ECDSA is a widely adopted digital signature standard. A number of threshold protocols for ECDSA have been developed that let a set of parties jointly generate the secret signing key and compute signatures, without ever revealing the signing key. Threshold protocols for ECDSA have seen recent interest, in particular due to the need for additional security in cryptocurrency wallets where leakage of the signing key is equivalent to an immediate loss of money. We propose a threshold ECDSA protocol secure against an active adversary in the honest majority model with abort. Our protocol is efficient in terms of both computation and bandwidth usage, and it allows the parties to pre-process parts of the signature, such that once the message to sign becomes known, they can compute a secret sharing of the signature very efficiently, using only local operations. We also show how to obtain guaranteed output delivery (and hence also fairness) in the online phase at the cost of some additional pre-processing work, i.e., such that it either aborts during the pre-processing phase, in which case nothing is revealed, or the signature is guaranteed to be delivered to all honest parties online.
Anonymity and rewards in peer rating systems1
Authors: Garms Lydia , Ng Siaw-Lynn , Quaglia Elizabeth A. , Traverso Giulia
Published: November 2021

When peers rate each other, they may rate inaccurately to boost their own reputation or unfairly lower another’s. This could be mitigated by having a reputation server incentivise accurate ratings with a reward. However, assigning rewards becomes challenging when ratings are anonymous, since the reputation server cannot tell which peers to reward for rating accurately. To address this, we propose an anonymous peer rating system in which users can be rewarded for accurate ratings, and we formally define its model and security requirements. In our system ratings are rewarded in batches, so that users claiming their rewards only reveal they authored one in this batch of ratings. To ensure the anonymity set of rewarded users is not reduced, we also split the reputation server into two entities, the Rewarder, who knows which ratings are rewarded, and the Reputation Holder, who knows which users were rewarded. We give a provably secure construction satisfying all the security properties required. For our construction we use a modification of a Direct Anonymous Attestation scheme to ensure that peers can prove their own reputation when rating others, and that multiple feedback on the same subject can be detected. We then use Linkable Ring Signatures to enable peers to be rewarded for their accurate ratings, while still ensuring that ratings are anonymous. Our work results in a system which allows accurate ratings to be rewarded, whilst still providing anonymity of ratings with respect to the central entities managing the system.
Comparison of functional outcome scales in paediatric acute encephalitis: Responsiveness and outcome predictors
Authors: Teo Jia Hui , Shabhani Sheru , Qiao Fan , Ng Zhi Min , Chan Derrick Wei-Shih
Published: November 2021

PURPOSE: To compare scoring systems and their ability to capture short and long-term recovery of paediatric patients with acute encephalitis. To identify clinical predictors of short-term outcomes by correlating functional outcome measures at 1 month post diagnosis of acute encephalitis. METHODS: Patients with encephalitis diagnosed between July 2011 and 2016 based on Granerod’s criteria were studied in this retrospective cohort study. Functional outcome scores on WeeFIM, LOS, GOS-E, mRS and ICF at initial presentation and 1, 3, 6 and 12 months later were compared. RESULTS: WeeFIM and LOS scores both showed maximum change in the first 3 months, reflecting highest recovery in this period. With WeeFIM, the greatest change occurred within the first month following diagnosis. On univariate analysis, seizure frequency in the first month, presence of movement disorder, presence of autonomic dysfunction and lower baseline functional score was associated with poorer WeeFIM scores at 1 month. The latter three variables remained statistically significant on multivariate analysis. CONCLUSION: WeeFIM is a potentially preferred functional outcome assessment tool as it demonstrated greatest recovery within the first month due to a trend of high responsiveness and relatively low ceiling effect. Presence of autonomic dysfunction and movement disorders at diagnosis correlated with poorer outcome at 1 month post diagnosis.
Breast cancer suppression by curcumin-naringenin-magnetic-nano-particles: In vitro and in vivo studies
Authors: Askar Mostafa A. , El Shawi Omama E. , Abou zaid Omayma A.R. , Mansour Nahla A. , Hanafy Amal M.
Published: November 2021

BACKGROUND:

The limitations of surgery, radiotherapy, and chemotherapy in cancer treatment and the increase in the application of nanomaterials in the field of biomedicine have promoted the use of nanomaterials in combination with radiotherapy for cancer treatment.

OBJECTIVE:

To improve the efficiency of cancer treatment, curcumin-naringenin loaded dextran-coated magnetic nanoparticles (CUR-NAR-D-MNPs) were used as chemotherapy and in combination with radiotherapy to verify their effectiveness in treating tumors.

METHODS:

CUR-NAR-D-MNPs were prepared and studied by several characterization methods. Median inhibitory concentration (IC50) and cellular toxicity were evaluated by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The cell death and radiosensitization were studied by acridine orange/ethidium bromide dual staining of MCF-7 human breast cancer cells.

RESULTS:

CUR-NAR-D-MNPs induce apoptosis and inhibited cell proliferation through reactive oxygen species (ROS) generation. CUR-NAR-D-MNPs used alone had a certain therapeutic effect on tumors. CUR-NAR-D-MNPs plus radiotherapy significantly reduced the tumor volume and led to cell cycle arrest and induction of apoptosis through modulation of P53high, P21high, TNF-αlow, CD44low, and ROShigh signaling

CONCLUSIONS:

CUR-NAR-D-MNPs are effective in the treatment of tumors when combined with radiotherapy, and show radiosensitization effects against cancer proliferation in vitro and in vivo.
Evidence for V363 Cas as a First Overtone Anomalous Cepheid
Authors: Shawn Kafal
Published: November 2021

V363 Cassiopeiae was observed through 51 acquisitions of each of V, B, i and z filters, during a 15 day observation window. From the observations, folded light curves were generated using a PDM technique. It was my objective to provide further evidence for this star’s reclassification as a first overtone Anomalous Cepheid, as some past papers have proposed (Fernley, 1998). Based on our light curve characteristics (shape, and period), V363 Cas appeared to favor the anomalous Cepheid class over any RR Lyrae class. My observed period of 0.545 days is higher than the typical range of periods for RRd Lyrae, reported between 0.25 and 0.49 days (Soszynski et al., 2008). The RRab type Lyrae, as some have imposed on V363 Cas (Kholopov et al., 1985), was ruled out due to the evidence for overtone pulsation by Hajdu et al. (Hajdu, Jurcsik, et al., 2009) and Fernley (Fernley, 1998). Finally, a rough distance comparison to GAIA, using Nemec’s 1994 P-L-[Fe/H] for Anomalous Cepheids (Nemec, Nemec, & Lutz, 1994), estimated the distance of V363 Cas to be closer to the distance estimated by GAIA than estimates made with RRd class equations.
СУЧАСНІ ПЕДАГОГІЧНІ ТЕХНОЛОГІЇ ЯК ЧИННИК УСПІШНОЇ ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ ФАХІВЦІВ
Authors: ПЛАЧИНДА Тетяна
Published: November 2021

У статті актуалізовано питання необхідності застосування в освітньому процесі закладів вищої освіти сучасних педагогічних технологій з метою вдосконалення професійної підготовки майбутніх фахівців, зокрема авіаційної галузі. Зазначається, що одним із напрямів осучаснення освітнього процесу є SТЕМ-освіта. Наголошується, що метою вищої освіти є здобуття особою високого рівня наукових професійних і загальних компетентностей, необхідних для діяльності за певною спеціальністю чи в певній галузі знань. Аналізуються кваліфікаційні характеристики фахівці авіаційної галузі, які мають володіти комплексними компетентностями, зокрема розглянуто вимоги до інженера з управління повітряним рухом, диспетчера управління повітряним рухом, командира повітряного судна, пілота (другого пілота). Зазначається, що в епоху цифрових технологій та креативної економіки актуалізації набувають компетентності, що дозволять критично мислити, взаємодіяти та комунікувати, мати навички творчого підходу до справи. Зауважується, що зважаючи на тенденції викладання дисциплін в останні десятиліття (відповідність освітнього процесу сучасним тенденціям в галузі освіти та відображення в ньому останніх науково-технічних досягнень; активація пізнавальної діяльності; впровадження інформаційно-комунікаційних технологій; синергетичний підхід; упровадження останніх досягнень науки і техніки в освітній процес, сучасне навчальне обладнання; пріоритетним завданням освіти стає не стільки засвоєння певного об’єму знань умінь і навичок, скільки формування компетенцій, пов’язаних з подальшою професійною діяльністю, таких як: здатність до самоосвіти, ініціативність, уміння працювати в колективі, гнучкість і креативність мислення, інноваційність тощо), саме застосування засобів STEM-освіти дозволить розширити можливості ефективної й якісної професійної підготовки майбутніх фахівців, зокрема авіаційної галузі. Висновлюється, що означена сучасна педагогічна технологія демонструє потужний науковий потенціал для ефективної професійної підготовки майбутніх фахівців, із запровадженням пошуководослідницького підходу під час викладання навчальних дисциплін у закладах вищої освіти. Впровадження кращих європейських практик зі STEM-освіти та їхнє активне використання є перспективним напрямом у вищій школі України.
Dimensi Kearifan Lokal dalam Novel Laskar Pelangi
Authors: Suaedi Hasan
Published: November 2021

Kearifan lokal sering kali diartikan sebagai sebuah warisan budaya. Kearifan lokal dapat terbentuk melalui interaksi antar individu dalam suatu masyarakat dengan lingkungan tempat tinggalnya. Kearifan lokal secara teoritis mengandung tiga dimensi utama, yaitu pengetahuan, nilai, dan kepemimpinan. Ketiga dimensi tersebut sangat penting untuk diwariskan kepada generasi muda. Pewarisan kearifan lokal dalam novel Laskar Pelangi disosialisasikan melalui orangtua dan tokoh masyarakat. Oleh karena itu, proses sosialisasi kearifan lokal disampaikan melalui kekuasaan yang berbeda antara generasi muda, orang tua, dan tokoh masyarakat. Guna mengungkapkan dimensi kearifan lokal yang disosialisasikan oleh individu yang memiliki kuasa, maka peneliti menggunakan teori wacana kritis. Teori wacana kritis memnadang sebuah teks (novel) bagian dari interaksi sosial dan kebudayaan. Oleh karena itu, pengarang dalam menulis novel menginterpretasi pristiwa sosial ke dalam novelnya.Pendekatan dalam penelitian ini adalah kualitatif. Sedangkan jenis penelitian yang digunakan berupa kajian teks. Kajian teks dalam penelitian ini menggunakan model analisis data Fairlough. Luaran dalam penelitian ini adalah berupa laporan penelitian, eksplorisasi kearifan lokal, sebagai bahan pembelajaran bahasa dan sastra terutama untuk membentuk karekter peserta didik melalui budaya kearifan lokal. Kemudian penelitian ini ditargetkan dipublikasikan dalam jurnal terakreditasi. Jurnal terakreditasi yang menjadi target adalah Belajar Bahasa.Dimensi kearifan lokal dalam novel Laskar Pelang diungkapkan dengan tiga dimensi. Ketiga dimensi tersebut adalah (a) dimensi pengetahuan lokal yang terdiri dari cerdas cermat sebagai media untuk meningkatkan harkat dan martabat sekolah dan pengetahuan tentang guru linguasalnya, (b) dimensi nilai lokal yang dipercaya oleh masyarakat terdiri dari nilai lokal Islam dan nilai semangat dalam menempuh pendidikan formal, (c) dimensi mekanisme pengambilan keputusan lokal yang dijalankan oleh masyarakat terdiri dari kepala sekolah sebagai pengamil keputusan dan orang pintar sebagai pengambil solusi.