bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Efficacy of Intraoperative Cell Saver Autologous Blood Salvage in Emergency Thoracoscopic Surgery for Massive Hemothorax.
Authors: Itano Hideki , Takeda Takayuki , Nakahara Hidehito , Kobayashi Toshinori , Hinami Junsuke
Published: December 2020

Objectives: The objectives of this study were to investigate the efficacy of intraoperative Cell Saver autologous blood salvage in emergency thoracoscopic surgery for massive hemothorax.methods: Nine consecutive cases, including 8 idiopathic hemopneumothoraxes and 1 late-onset traumatic hemothorax, for which emergency surgery was performed at Uji Tokushu-kai Hospital between 2009 and 2016, were retrospectively reviewed. Results: The median total blood loss was 2200 cc (range, 840–4170 cc). Intraoperative Cell Saver autotransfusion with a median volume of 820 cc was performed in the last 7 patients. The first 2 patients who did not receive an autotransfusion required substantially more allogeneic blood transfusion (10 and 14U, respectively), while the other 7 autotransfusion patients required much smaller amounts of allogeneic transfusion (4 U in 3 and 0 U in 4). Four autotransfusion patients who did not undergo preoperative chest tube drainage and/or who had drainage of < 150cc received a greater amount of intraoperative autotransfusion (mean, 1162 ± 414 cc) than the other 3 patients who had a chest tube drainage of ≥ 150 cc (mean, 666.7 ± 150 cc; P = 0.0574). Torn and bleeding arteries were thoracoscopically clipped in 7 patients. One patient with right lung collapse over 2.5 days developed severe acute respiratory distress syndrome intraoperatively, but fully recovered. Conclusions: Utilizing intraoperative autologous blood salvage with the sparing of preoperative chest tube drainage to the maximum possible extent is an efficient strategy to reduce both overall blood loss and allogeneic blood transfusion in emergency thoracoscopic surgery for massive hemothorax.
Seroepidemiology of respiratory syncytial virus infection in rural and semi-rural areas of the Littoral Region of Cameroon
Authors: Mandi Henshaw Eyambe , Epie Bekolo Cavin , Eyoh Agnes , Jan Sindhiya , Clemens Sue Ann Costa , Clemens Ralf , Yimer Solomon Abebe
Published: December 2020

Background The respiratory syncytial virus (RSV) has been established as a leading cause of acute lower respiratory illness (ALRI) in infants and children. In 2015, the global disease burden (GBD) study estimated that the overall RSV-ALRI mortality could be as high as 118 200, with most death occurring in low- and middle-incomes countries (LMICs). This study aimed to assess the burden of RSV infection among children less than two years with acute respiratory infections (ARI) in the Littoral region of Cameroon. Methods We carried out a cross-sectional study in seven health centres in the Littoral region of Cameroon. Venous blood was collected using serum separation tubes from eligible children who visited these health centres with acute respiratory infections. ELISA testing was used to assess the seroprevalence of anti-IgM RSV for the total population and by selected demographic and health parameters and potential risk factors. Results The overall RSV-associated ARI seroprevalence was 33% (95%CI:23.6-42.3; 33/100 children). The only demographic factor significantly associated with RSV acquisition was age of six months and below (odds ratio: 7.54 (2.62, 23.36); p=0.000). Children who were clinically diagnosed to be concomitantly infected with malaria had a lower risk of RSV infection (odds ratio: 0.38 (0.14, 0.95; P = 0.03). Conclusions The RSV burden is high among children less than two years with ARI in the Littoral region of Cameroon. There is a need for an effective public health RSV surveillance system with standard laboratory techniques and equipment to better understand the RSV disease age-specific incidence, seasonality, risk factors and RSV burden among patients in communities in Cameroon.
Current status of periodontitis and its association with tobacco use amongst adult population of Sunsari district, in Nepal
Authors: Goel Khushboo , Sharma Shivalal , Baral Dharnidhar , Agrawal Santosh
Published: December 2020

Background: Tobacco products are considered significant, but preventable factors related to initiation and progression of periodontal diseases. We assessed the prevalence of periodontitis and evaluated its association with tobacco use and other factors amongst the adult population of Sunsari district in eastern Nepal.Methods: A community-based, cross-sectional study was conducted in rural municipalities in the province one of eastern Nepal. A total of 440 adults were interviewed with a set of a standardized pre-tested semi-structured questionnaire. Data on social demographics, adverse oral habits followed by periodontal clinical examination were recorded. Prevalence of periodontitis was assessed by a case definition provided by CDC-AAP. Univariate and multivariate logistic regression analysis was done to measure the association between tobacco use and other factors with periodontitis.Results: The overall prevalence of periodontitis was found to be 71.6%. Majority (85.4%) of tobacco users had periodontitis and they were significantly associated with the disease and its severity. The study identified age groups, 45-65 years (AOR=7.58, 95% CI, 3.93-14.61), plaque accumulation (AOR=1.01, 95% CI, 1.00- 1.02), smoking (AOR=3.14, 95% CI, 1.36- 7.27), khaini users (smokeless tobacco, AOR=2.27, 95% CI, 1.12-4.61) and teeth loss (AOR=2.02, 95% CI, 1.21-3.38) as the significant factors associated with periodontitis. Conclusion: The prevalence of periodontitis is high in the surveyed rural adult population. Cigarette smoking along with the use of smokeless tobacco in the form of khaini were identified as significant factors associated with periodontitis.
Quality of care for children with malaria at private health facilities in Mid-Western Region of Uganda: A cross section study
Authors: Wanzira Humphrey , Tumwine Daniel , Bukoma Patrick , Musiime Allan , Biculu Juliet , Ediamu Tom , Gudoi Samuel , Tibenderana James , Mulebeke Ronald , Nantanda Rebecca , Achan Jane
Published: December 2020

Background: Approximately 50 percent of the population in Uganda seeks health care from private facilities but there is limited data on the quality of care for malaria in these facilities. This study aimed to document the quality of malaria case management in private health facilities innine districts in the Mid-Western region of Uganda, an area of moderate malaria transmission. Methods: This was a cross sectional study in which purposive sampling was used to select fifteen private-for-profit facilities from each district. An interviewer-administered questionnaire that contained both quantitative and open-ended questions was used. Information was collected on availability of treatment aides, knowledge on malaria, malaria case management, laboratory practices, malaria drugs stock and data management. We determined the proportion of health workers that adequately provided malaria case management according to national standards. Results: Of the 135 health facilities staff interviewed, 61.48% (52.91 - 69.40) had access to malaria treatment protocols while 48.89% (40.19 - 57.63) received malaria training. The majority of facilities, 98.52% (94.75 - 99.82) had malaria diagnostic services and the most commonly available anti-malarial drug was artemether-lumefantrine, 85.19% (78 - 91), followed by Quinine, 74.81% (67 - 82) and intravenous artesunate, 72.59% (64 – 80). Only 14.07% (8.69 – 21.10) responded adequately to the acceptable cascade of malaria case management practice. Specifically, 33.33% (25.46 - 41.96) responded correctly to management of a patient with a fever, 40.00% (31.67 - 48.79) responded correctly to the first line treatment for uncomplicated malaria, whereas 85.19% (78.05 - 90.71) responded correctly to severe malaria treatment. Only 28.83% submitted monthly reports, where malaria data was recorded, to the national database. Conclusion: This study revealed sub-optimal malaria case management practices at private health facilities with approximately 14% of health care workers demonstrating correct malaria case management cascade practices. To strengthen the quality of malaria case management, it is recommended that the NMCD distributes up to date guidelines and tools, coupled with training; continuous mentorship and integrated supportive supervision; provision of adequate stock of essential anti-malarials and RDTs; reinforcing communication and behavior change approach and increasing support for data management at private health facilities.
Transjugular Intrahepatic Portosystemic Shunt for Hepatic Sinusoidal Obstruction Syndrome Associated with Consumption of Gynura Segetum
Authors: Zhang Lijie , Li Qing , Makamure Joyman , Zhao Dan , Liu Ziyi , Zheng Chuansheng , Liang Bin
Published: December 2020

Background: To evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) on hepatic sinusoidal obstruction syndrome (HSOS) associated with consumption of Gynura segetum (GS). Methods: We retrospectively reviewed 9 consecutive patients with GS-related HSOS who were refractory to supportive treatment and underwent TIPS at our institution between January 2014 and September 2019. The patients were evaluated for safety and efficacy, including TIPS complications and changes in portosystemic pressure gradient (PPG), ascites, total bilirubin, liver size and portal vein diameter. Results: TIPS procedures were performed successfully in the 9 patients, without any TIPS technique-related complications. The PPG was improved by TIPS in all patients (mean PPG before TIPS, 30.4 ± 5.2 vs. 13.0 ± 4.1 mm Hg post-TIPS, P=0.008). Except for one patient who was lost to follow-up, the remaining 8 patients survived with a median follow-up period of 12 months (range, 5-39 months). Although the level of total bilirubin was significantly increased 5-7 days after TIPS compared with that before the procedure (3.57 ± 1.58 vs. 4.82 ± 2.06 mg/dl, P=0.017), it returned to baseline level at 1-month follow-up (3.53 ± 2.72 vs. 4.82 ± 2.06 mg/dl, P=0.401). The patients experienced complete resolution or obvious reduction of ascites (P<0.001), significant reduction of liver size (16.7 ± 2.2 vs. 13.7 ± 1.7 cm, P=0.018), and significant enlargement of the portal trunk (10.7 ± 2.5 vs. 13.4 ± 2.4 mm, P=0.017) after TIPS compared to the pre-TIPS state. Conclusion: TIPS may offer a potentially useful treatment for the GS-related HSOS.
Three-dimensional Construction of Micrometer Level in Rat Stomach by Synchrotron Radiation
Authors: Tao Qiang , Gao Chen-Chen , Tong Xue-Hong , Yuan Shi-Zhen , Xu Jingdong
Published: December 2020

Background: The structural changes of gastric mucosa are considered as an important window of early gastric lesions. This article shows an imaging method of the stomach that does not use imaging agents. X-ray phase-contrast images of different stages of gastric development were taken using micrometer level X-ray in-line phase-contrast imaging (XILPCI) technique on synchrotron radiation facility. The aim of the study was to demonstrate that the imaging technique is an appropriate method for micron imaging of the gastric structures.Methods: The stomachs of 4-, 6- and 12-week-old rats were removed and cleaned. XILPCI has 1000 times greater soft tissue contrast than that of X-ray traditional absorption radiography. The projection images of the rats stomachs were recorded by an XILPCI charge coupled device (CCD) at 9 μm image resolution.Results: The X-ray in-line phase-contrast images of the different stages of rats’ gastric specimens clearly showed the gastric architectures and the details of the gastro-duodenal region. 3-dimensional stomach anatomical structure images were reconstruction.Conclusion: The reconstructed gastric 3D images can clearly display the internal structure of the stomach. XILPCI may be a useful method for medical research in the future.
“Preterm birth risk, me?” Women risk perception about premature delivery
Authors: Silva Thaís Valéria , Bento Silvana Ferreira , Katz Leila , Pacagnella Rodolfo
Published: December 2020

Background: Risk perception is based on collective indicators, but it is influenced by the individual’s self-perception of his health-disease process. This study aims to investigate the risk perception of pregnant who were identified as high-risk for premature birth and to seek strategies for better management of such cases.Methods: This is a cross-sectional study where women who had completed their participation in P5 trial were contacted and invited to answer a structured questionnaire with open questions. Data were collected by telephone and analyzed using thematic analysis. The analysis categories were defined, and all the answers were reviewed, categorized, grouped, and a descriptive summary was prepared.Results: 208 Brazilian women have participated.Three categories were identified: 1) Risk perception mediated by health professionals; 2) Self-perception of risk through personal experiences and relationships; 3) Perception of treatment success. After receiving an explanation from a healthcare professional about short cervix and premature birth, women understood the risk of premature delivery, recognizing the importance of early diagnosis to prevent premature birth. Unsuccessful previous experiences in prior pregnancies influenced women's risk perception. Patients believed in the success of the treatment performed, placing their hopes on the treatment even without research guarantees about benefits.Conclusion: Pregnant women’s risk perception regarding prematurity is based partly on personal and family experiences but mainly on information given by healthcare professionals. The risk perception about preterm birth may contribute to healthy pregnancy, guiding necessary interventions and preventing adverse outcomes. Prevention studies on prematurity should thus focus on neonatal outcomes.
CERTL reduces C16 ceramide, amyloid-β levels and inflammation in a model of Alzheimer's disease
Authors: Crivelli Simone Mwenda , Luo Qian , Stevens Jo , Giovagnoni Caterina , Kruining Daan van , Bode Gerard , Hoedt Sandra den , Hobo Barbara , Scheithauer Anna-Lena , Walter Jochen , Mulder Monique T , Exley Christopher , Mold Matthew J. , Mielke Michelle M. , De Vries Helga E , Wouters Kristiaan , Hove Daniel L.A. van den , Berkes Dusan , Ledesma María Dolores , Verhaagen Joost , Losen Mario , Bieberich Erhard , Martinez-Martinez Pilar
Published: December 2020

Background: Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers, crucial for ceramide and sphingomyelin balance in cells. Extracellular forms of CERTs co-localize with amyloid-β (Aβ) plaques in AD brains. To date, the significance of these observations for the pathophysiology of AD remains uncertain.Methods: The plasmid expressing CERTL, the long isoform of CERTs, was used to study the interaction of CERTL with amyloid precursor protein (APP) by co-immunoprecipitation and immunofluorescence in HEK cells. The recombinant CERTL protein was employed to study interaction of CERTL with amyloid-β (Aβ), Aβ aggregation process in presence of CERTL, and the resulting changes in Aβ toxicity in neuroblastoma cells. CERTL was overexpressed in neurons by adeno associated virus (AAV) in a familial mouse model of familial AD (5xFAD). Ten weeks after transduction, animals were challenged with behavior tests for memory, anxiety and locomotion. At week twelve, brains were investigated for sphingolipid levels by mass spectrometry, plaques and neuroinflammation by immunohistochemistry, gene expression and/or immunoassay.Results: Here, we report that CERTL, binds to APP, modifies Aβ aggregation and reduces Aβ neurotoxicity in vitro. Furthermore, we show that intracortical injection of AAV, mediating the expression of CERTL, decreases levels of ceramide d18:1/16:0 and increases sphingomyelin levels in the brain of male 5xFAD mice. CERTL in vivo over-expression has a mild effect on animal locomotion, decreases Aβ formation and modulates microglia by decreasing their pro-inflammatory phenotype.Conclusion: Our results demonstrate a crucial role of CERTL in regulating ceramide levels in the brain, in amyloid plaque formation and neuroinflammation, thereby opening research avenues for therapeutic targets of AD and other neurodegenerative diseases.
Prognostic value of Glypican family genes in early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy and possible mechanisms
Authors: Liu Jun-qi , Liao Xi-wen , Wang Xiang-kun , Yang Cheng-kun , Zhou Xin , Liu Zheng-qian , Han Quan-fa , Fu Tian-hao , Zhu Guang-zhi , Han Chuang-ye , Su Hao , Huang Jian-lu , Ruan Guo-tian , Yan Ling , Ye Xin-ping , Peng Tao
Published: December 2020

Background: This study explored the prognostic significance of Glypican (GPC) family genes in patients with pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Methods: A total of 112 PDAC patients from TCGA and 48 patients from GEO were included in the analysis. The relationship between overall survival and the expression of GPC family genes as well as basic clinical characteristics was analyzed using the Kaplan-Meier method with the log-rank test. Joint effects survival analysis was performed to further examine the relationship between GPC genes and prognosis. A prognosis nomogram was established based on clinical characteristics and prognosis-related genes. Prognosis-related genes were investigated by genome-wide co-expression analysis and gene set enrichment analysis (GSEA) was carried out to identify potential mechanisms of these genes affecting prognosis. Results: In TCGA database, high expression of GPC2 , GPC3 , and GPC5 was significantly associated with favorable survival (log-rank P = 0.031, 0.021, and 0.028, respectively; adjusted P value = 0.005, 0.022, and 0.020, respectively), and joint effects analysis of these genes was effective for prognosis prediction. The prognosis nomogram was applied to predict the survival probability using the total scores calculated. Genome-wide co-expression and GSEA analysis suggested that the GPC2 may affect prognosis through sequence-specific DNA binding, protein transport, cell differentiation and oncogenic signatures (KRAS, RAF, STK33, and VEGFA). GPC3 may be related to cell adhesion, angiogenesis, inflammatory response, signaling pathways like Ras, Rap1, PI3K-Akt, chemokine, GPCR, and signatures like cyclin D1, p53, PTEN. GPC5 may be involved in transcription factor complex, TFRC1, oncogenic signatures (HOXA9 and BMI1), gene methylation, phospholipid metabolic process, glycerophospholipid metabolism, cell cycle, and EGFR pathway. Conclusion: GPC2 , GPC3 , and GPC5 expression may serve as prognostic indicators in PDAC, and combination of these genes showed a higher efficiency for prognosis prediction.
Genome-wide association analysis reveals genetic variations and candidate genes associated with salt tolerance related traits in Gossypium hirsutum
Authors: Xu Peng , Guo Qi , Meng Shan , Zhang Xianggui , Xu Zhenzhen , Guo Wangzhen , Shen Xinlian
Published: December 2020

Background: Cotton is more resistant to salt and drought stresses as compared to other field crops, which makes itself as a pioneer industrial crop in saline-alkali lands. However, abiotic stresses still negatively affect its growth and development significantly. It is therefore important to breed salt tolerance varieties which can help accelerate the improvement of cotton production. The development of molecular markers linked to causal genes has provided an effective and efficient approach for improving salt tolerance.Results: In this study, a genome-wide association study (GWAS) of salt tolerance related traits at seedling stage was performed based on two years of phenotype identification for 217 representative upland cotton cultivars by genotyping-by-sequencing (GBS) platform. A total of 51,060 single nucleotide polymorphisms (SNPs) unevenly distributed among 26 chromosomes were screened across the cotton cultivars, and 25 associations with 27 SNPs scattered over 12 chromosomes were detected significantly (-log10p>4) associated with three salt tolerance related traits in 2016 and 2017. Among these, the associations on chromosome A13 and D08 for relative plant height (RPH), A07 for relative shoot fresh matter weight (RSFW), A08 and A13 for relative shoot dry matter weight (RSDW) were expressed in both environments, indicating that they were likely to be stable quantitative trait loci (QTLs). A total of 12 salt-induced candidate genes were identified differentially expressed by the combination of GWAS and transcriptome analysis. Three promising genes were selected for preliminary function verification of salt tolerance. The increase of GH_A13G0171-silenced plants in salt related traits under salt stress indicated its negative function in regulating the salt stress response.Conclusions: These results provided important genetic variations and candidate genes for accelerating the improvement of salt tolerance in cotton.
Effect of Insert Angles on Cutting Tool Geometry
Authors: Shvets S. V. , Astakhov V. P.
Published: December 2020

An analysis of publications has shown that mechanically clamped indexable inserts are predominantly used in modern tool manufacturing. Each insert has its shape and geometry in the tool coordinate system. The static system’s required geometry is achieved by the tilting of the insert pocket in the radial and axial directions. Therefore, it is of great importance in the tool design to know the relationships between the insert’s geometry parameters in the tool coordinate system where the geometry paraments of the insert are defined and working geometry parameters of the tool defined in the static coordinate system. The paper presents the developed methodology for determining the insert pocket base surface position to ensure the required values of the tool geometry parameters of the selected indexable insert in the static coordinate system. The graphs of the dependence of each of the angles of the insert geometry on the angles of rotation of this insert in the front and profile planes are presented as the level lines for practical use. Using these graphs, one can optimize all geometric insertion parameters in the static coordinate system. The model of the calculations of the mechanism of the insert clamping by a screw is developed. The basic size and tolerance of the output link determine the distance from the intersection line of the base surfaces to the thread axis on the pocket and the minimum amount of the screw stroke on the insert clamping in the pocket.

Keywords: indexable insert, cutting tool, coordinate system, base surfaces, geometric parameters.
WOMEN EQUAL SHAREHOLDERS IN HINDU JOINT FAMILY, WITH SPECIAL REFERENCE TO THE CASE OF - VINEETA SHARMA VS RAKESH SHARMA & ORS
Authors:   B.A.LL.B (4th year) New Law College, Bharati Vidyapeeth deemed to be University, Pune., Verma Abhinit , Kant Choudhary Krishna ,   B.A.LL.B (4th year) New Law College, Bharati Vidyapeeth deemed to be University, Pune.
Published: December 2020

This Research Paper will coverthe concept ofÂ–whether women have equal shares over the coparcenary property or not & on the other hand it will also discuss the landmark judgment of Vineeta Sharma V/S Rakesh Sharma which has opened up a space for the women to have equal shares in the ancestral property of Hindu Undivided Family.Since the inception of the Hindu Succession Act, 1956 the provision for the division of property of Hindu Undivided Family was only limited to the sons but the amendment of 2005 made some of the special changes to the act, adding daughters as the equal shareholders to the coparcenary property and even this amendment providedthat,the daughter can be the Karta of the Hindu Undivided Family.With special reference to the case of Vineeta Sharma vs Rakesh Sharma this research note will provide in-depth analysis with conflicting case laws where it will be put forth whether the coparcenary property are the property of the sons or even the daughter can claim for equal shares over the Hindu Undivided Family property.
IMPACT OF COVID-19 ON THE TOURISM INDUSTRY IN INDIA
Authors:   ijar, Dogra Twinkal
Published: December 2020

The purpose of this study is to examine the effect of COVID-19 on the tourism industry in India. The tourism industry as compared to the other important industries of a country is highly affected due to the internal and external shocks. In the past few months, the drastic outbreak of the novel coronavirus has caused great losses to the tourism industry. The Indian tourism industry accounted for 9.2% of Indias GDP in 2018 and braced 42.673 million jobs, 8.1% of its total employment.The Indian tourism and hospitality industry is now gawking at a likely job loss of around 38 million. The governments across the world are trying to woo back visitors from domestic and international markets. Travel and tourism companies will have to recuperate the trust and confidence of people in the recovery period to travel again after the pandemic. The present study suggests that the travel and hospitality sector should restructure their approach by introducing measures like changing peoples social behavior, wearing a mask when stepping out, social distancing, and hesitation to travel far distances.
ROLE OF R2TP COMPLEX IN LYMPHOMA AND ITS THERAPEUTIC POTENTIAL
Authors:   Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029., Lone Moien , Akhter Qulsum ,   Government Degree College for Women, Nawakadal Srinagar-190002., Kumar Mithilesh ,   School of Life Sciences, Jaipur National University, Jagatpura, Jaipur-302017., Maqbool Umar ,   Department of Surgery, All India Institute of Medical Sciences, New Delhi-110029., Shadang Mahaiwon ,   Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029.,   Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029., S. Chauhan Shyam ,   Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029., A. Mir Riyaz ,   Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029.
Published: December 2020

The R2TP complex which comprises of RUVBL1, RUVBL2, PIH1D1 and RPAP3 in humans is known to be a specialized Co-chaperone of Hsp-90 protein. This multimeric-protein complex is involved in the assembly and maturation of several multi-subunit complexes including RNA polymerase II, small nucleolar ribonucleoproteins, and complexes containing phosphatidylinositol-3-kinase-like kinases. Since their discovery as a co-chaperone of Hsp90, the R2TP complex is involved in multitude of cellular processes including, chromatin remodelling, transcription regulation, ribonucleoprotein complex biogenesis, mitotic assembly, telomerase complex assembly, and apoptosis. Lymphoma arises from the abnormal proliferation of B-cells and the R2TP complex have been reported to play an important role in the activation of p53 and RB. Therefore, the inactivation in any of the tumor suppressor pathways can drive cells to malignancy.However, there are multiple factors which may contribute towards malignancy but the folding defects in these tumor suppressor pathways could be one of the reasons. R2TP is tightly linked with oncogenesis and its inhibition can decrease the proliferation activity of cancer cells. So, the multisubunit chaperone complex as well as its components could be promising candidates for cancer chemotherapy.
STRATEGIC DEVELOPMENT PLAN OF SELECTED STATE UNIVERSITIES AND COLLEGES (SUCS) IN CALABARZON: AN EMERGING PROCESS FOR FACULTY DEVELOPMENT PROGRAM
Authors:   Laguna State Polytechnic University- Santa Cruz-Main Campus, Philippines., C. Ampo Richard
Published: December 2020

The qualifications and the competencies of the faculty is a stronghold in bringing up the quality of education in the tertiary level. Hence, this study looks through in-depth analysis the provisions in the Strategic Development Plan (SDP), focus on Faculty Development. Thus, the result becomes an outlined process for recommendation in the formulation of an action plan in the institutional level vis-Ã -vis faculty development program.Descriptive survey method was employed in this study to determine the perception of the respondents on the existence of the provisions in the Strategic Development Plan of 5 SUCs in CALABARZON, Region IV-A. Results of the study showed that all the indicators of SDP-planning, finance, management intervention, leadership focus, and learning opportunities, were perceived highly observable in connection with faculty professional development and faculty skills improvement. Likewise, findings revealed highly significant relationship among the variables under consideration. Pertinent to the outcomes of the study, teachers in higher education should enhance their professional discipline, which include interpersonal and social skills, professional growth, management and leadership abilities, as well as paralegal knowledge. It is therefore necessary to strengthen SDP comprehensively with a collaborative efforts of higher school officials and faculty to achieve the targeted goals of the SUCs towards better student learnings resulting to global-quality graduates.As to the findings of the study, it was concluded that the provisions contained in the Strategic Development Plan have significant relationship with faculty professional development and faculty skills improvement. With this finding, the null hypothesis stated as there is no significant relationship between the universitys SDP and faculty professional, faculty skills development is partially sustained.
MODELING METAL NANOPARTICLES INFLUENCE TO PROPERTIES OF SILICON SOLAR CELLS
Authors:   Bachelor Student, Department of Physics, Andijan State University, Uzbekistan., Gulomov Jasurbek , Aliev Rayimjon ,   Professor, Department of Physics, Andijan State University, Uzbekistan., Nasirov Murad ,   Docent, Department of Physics, Andijan State University, Uzbekistan., Ziyoitdinov Jakhongir ,   PhD Student, Department of Physics, Andijan State University, Uzbekistan.
Published: December 2020

Nanotechnologies are entering every field. Nanoparticles have been widely used in medicine and technology. We decided to study the behavior of nanoparticles under the influence of light and its effects on solar cells, based on a number of properties. How gold and silver nanoparticles are introduced into the optical layer of the solar cell has been studied enough to affect the properties of the solar cell. However, the effect of silicon-based solar cell metal nanoparticles in the n domain on the solar cell has not been sufficiently studied. In addition, in this study, the properties of solar cells, which included nanoparticles of various shapes, were modeled. Since the end of the last century, new methods of modeling have been introduced into scientific research. A lot of modeling software has been developed. They are based on a numerical method. Synopsys program of Sentaurus TCAD software package was used in the modeling to ensure the accuracy and reliability of the research. Using Sentaurus TCAD, a model of a silicon-based solar cell with simple and various shapes of platinum nanoparticles embedded in the n field was developed. The focus is on determining the effect of the shape of a nanoparticle introduced on solar cells on its properties. The effect of nanoparticles on the optical and I-V characteristics of a solar cell is also analyzed in depth.
IMPLEMENTING QUALITY A MISSING PIECE WITH A NEED FOR PROCESS OF BEHAVIOR CHANGE: A CASE FOR IMPLEMENTING QUALITY CB-IRS DELIVERY MODEL IN ZAMBIA
Authors:   Ministry of Health,National Malaria Elimination Centre, Lusaka, Zambia., Hakwia Kooma Emmanuel , Zinyengere David ,   Health Environment and Developmen Consultancy(HEDEC), Zimbabwe.
Published: December 2020

Background: In the wake of increasing malaria cases in Zambia, IRS has been coming under increasing accountable pressurefromthe publicfor quality IRS performance and its decentralized approach. In response, anew IRS approach Community-BasedIndoor Residual Spraying (IRS)Delivery model has been introduced in the country and institutionalized in the community health care system.The objective of this study was to introduce quality assurance approach methods to the model in terms of structure, process and outcomes for quality performance. Materials and Methods: We reviewed both published and unpublished documents, articles, papers on quality service delivery and explored field experiences and the understanding of IRS service delivery. The Donabedian model has been found to lead to improvements of quality that in turn could improve the health outcome of the community. Equally, dimensions of quality were analyzed under effectiveness, efficacy, acceptability, equity and relevance to IRS delivery of services and best approaches. Results: Quality assurance becomes strong and successful when its well organized with features of a health atmosphere that motivates IRS teams, Spray operators (SOPs), and the house hold owners, thus becoming a common goal as a result of good level management. The District IRS Operational Committee, typically must possess quality assurance superior technical skills and expertise. However, it is not only quality assurance guidelines that strengthen team building but also established rules, processes, tracking ofprogress, IRS quality assurance learningenvironment, improvements and leadership support initiatives. These could be supplemented by enabling tools and a nurturing qualityfriendly atmosphere within the IRS teams and SOPs as front liners. Donabedian model for improvement of quality has been widely adopted in the hospital care set up, but hasnot yet been fully recognized, utilized and validated in the vector control system. Conclusion: The study suggests that the Donabedian`s structure-process-outcome isa valid modelfor implementingquality CB-IRS Delivery model in the IRS program campaign. The interventions that perform well in terms of structure tend to perform better forquality service delivery processes, that in turn have favorable influence on the community health status outcome.
STRUCTURAL, MORPHOLOGICAL AND VIBRATIONAL STUDIES OF MAGNESIUM DOPED LITHIUM TITANATE ANODE MATERIALS FOR LI-ION BATTERIES
Authors:   Department of Nuclear Physics, Andhra University, Visakhapatnam, 530003, India., Vijaya Lakshmi D. , Vikram Babu B. ,   Department of Physics, Aditya Engineering College (A), Kakinada, 533005, India., Sushma Reddi M. ,   Department of Physics, Dr. B. R. Ambedkar University, Srikakulam, 532410, India., Raju M. K. ,   Department of HBS, WISTM Engineering College, Visakhapatnam, 531173, India., Rama Krishna A. ,   Department of ECE, Aditya College of Engineering and Technology, Kakinada, 533005, India., Samatha K. ,   Department of Physics, Andhra University, Visakhapatnam, India -530003., Lakshmi Narayana P.V. ,   Department of Nuclear Physics, Andhra University, Visakhapatnam, 530003, India.
Published: December 2020

In the present paper, we study the results of the substitution of Mg2+ in Li4Ti5O12 anode materials with the chemical composition of Li4-xMgxTi5O12 with x = 0, 0.1 and 0.3. Spinel structured Li4-xMgxTi5O12 materials are prepared by conventional ceramic method. The structural, morphological, chemical compostion and vibrational studies of the prepared anode samples are systematically characterized by thermal analysis, XRD, SEM, EDS and FT-IR. Phase formation is confirmed by thermal analysis followed by the XRD and FT-IR spectroscopic results. The X-ray diffraction (XRD) technique exposed that the materials belonged to spinel type having the space group as Fd-3m. Synthesized samples are quite large upto 0.98 to 1.3 ?m in diameter and the grain size had a wide distribution range. EDS is used to identify the elements. The FT-IR spectra show tetrahedral and octahedral sites to be inhabited by the MO6 oxide lattice.
GENETIC ALGORITHMS APPROACH FOR OPTIMIZATION OF HYBRID POWER PLANT SIZING IN SAHELIAN ZONE: CASE STUDY IN BURKINA FASO
Authors:   Laboratoire de Recherche en Energetique et Meteorologie de lEspace (LAREME), Norbert ZONGO University, Koudougou, Burkina Faso., Tissologo Moussa , Ouedraogo Seydou ,   Department of Electrical Engineering, University Institute of Technology, Nazi BONI University, 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso., Ouattara Frederic ,   Laboratoire de Recherche en Energetique et Meteorologie de lEspace (LAREME), Norbert ZONGO University, Koudougou, Burkina Faso.
Published: December 2020

Electrification development in rural areas is essential in order to meet electricity needs at bearable cost, for rural areas population development. This work presents optimization of hybrid electric power plant composed of solar photovoltaic and biogas generators, without electrical energy storage, for low-cost electrification of rural and peri-urban areas, at four sites in Sahel region of Burkina Faso. Simulation results give electricity kilowatt-hour cost about 0.0616 dollar at Gorom-Gorom site, 0.0611 dollar at Dori site, 0.0616 dollar at Djibo site and 0.0616 dollar at Sebba site. Compared to kilowatt-hour cost charged by the national electricity distribution company, who is from 0.1345 dollar, produced electricity cost at these sites is very competitive and accessible for this region population. Use of biogas in addition to solar as an energy source for electrical hybrid power plant has made it possible to reduce significantly polluting and greenhouse gas emissions.
WOMEN AND WORK IN MANIPUR
Authors:   Assistant Professor, Department of Economics, Manipur University., Sophia Arambam
Published: December 2020

Women in Manipur are noted for their high economic work participation rates. A trip through all the lanes, by- lanes, markets of Manipur will depict active participation of women in economic activity of the economy. There is the all-women Ima Market in the heart of Imphal City which is run almost exclusively by women vendors since ancient times. It seemed as if no other place in India will ever see such active participation of women in economic activity. The culture and ethos of the land speak of womens economic participation from ancient times.From traditional times, women had a greater role to play in the economic life of Manipur, compared to the patriarchy dominated rest of India. They face lesser discrimination than in other parts of the country. Moreover, social norms are such that there is lesser pressure on women to marry, greater freedom in their movement, in choice of occupation and in the choice of their life partner. Hence, they were able to play an active role in the economy. Census data show higher work participation of women in Manipur as compared to overall India, but NSS data do not always show such higher work participation rates, except insome years. Women are always working, in paid and in unpaid work but their work may not be effectively captured in official statistics. Theyconcentrate in the informal sector,in home-based work and in subsistence activities, the magnitude of which are sometimes difficult to capture adequately. The paper uses secondary data to study the employment status of women workers in the economy of Manipur. It shows how women of Manipur participate in productive sectors of the economy and in fact are the backbone of the economy of Manipur.
DEFINITION OF NEW SPATIAL REGIONS IN SOUTH-EAST EUROPE
Authors:   University of National and World Economy., Petrov Kamen
Published: December 2020

The exhibition presents the problems of cross-border cooperation and opportunities for partnership. Within the European Union, conditions are created for regional development on the national territory, as well as for border and cross-border cooperation. In this direction, the article outlines the processes of building a number of Euroregions, which are designed to promote regional development. This report will clarify some of the reasons for their construction, their role and what model of cooperation is available within the European Economic Area.
APPLICATIONS OF SOURCES OF SELF EFFICACY: SYNOPSISOFARTICLE REVIEW
Authors:   Department of Business and Management Studies, Trincomalee Campus, Eastern University, Sri Lanka., Priyadharsan S. , Saravanabawan A. ,   Department of Human Resource Management, Faculty of Management Studies and Commerce, University of Jaffna, Sri Lanka.
Published: December 2020

Self-efficacy is a vital concept and a key element for all sectors. Without self-efficacy, successful achievement cannot be achieved for every individual in an organization. Taking into account the sources of self-efficacy, it plays a major role in all sectors. The objectives of the review are to find out how the sources of self-efficacy apply to each sector and which factor is strongly influenced therein. Articles are collected from the period of 2001 to 2020. Review of research articles, it shows that the sources of self-efficacy applied in sports, career, education, marketing, social networks, health, etc. Finding revealed that most of the articles published in the field of education, career and sports. The mastery experience is strongly influenced by the variable. At the end of the review, most of the research has been carried out in an international context, very few research takes place in Sri Lanka. Further suggestion for the future should be to research organizations in the service sector.
DEVELOPMENT OF HIGHER EDUCATION IN INDIA SINCE INDEPENDENCE TO MODERN ERA
Authors:   Principal, Maa Vindhyavashini Post Graduate College of Education Padma, Hazaribag, Vinoba Bhave University., Prasad Chetlal , Kumar Sanjay ,   HOD (B.Ed.) J.J. College, Koderma, A constituent Unit of VinobaBhave University.
Published: December 2020

The institutional framework of higher education in India consists of Universities and Colleges. As reported in 2019, India has 993 universities and 39,931 colleges. One of the key objectives of the Department is to increase the Gross Enrolment Ratio (GER) in higher education to 30% by 2020. Higher Education system in the country is governed by multiple agencies with University Grant Commission (UGC) as the apex body. The rule and regulations by these agencies makes the higher education system more complex. The various stakeholders in the regulatory framework in the country are State Governments, professional councils like University Grant Commission (UGC), All India Council for Technical Education (AICTE), National Council for Teacher Education (NCTE) etc. and five professional councils at the state level like Rehabilitation Council of India (RCI), State Educational and Research Council (SCERT) etc. This regulatory arrangement of higher education in India is very complex and disfunctional. Global Initiative for Academics Network (GIAN): The programme seeks to invite distinguished academicians, entrepreneurs, scientists, experts from premier institutions from across the world, to teach in the higher educational institutions in India.UGCs Learning Outcome-based Curriculum Framework (LOCF) in HEIs.by updating curriculum fromacademic year 2019-20.and adopting learner centric teaching learning processes bysuitable improvement in the pedagogy.
Effect of feed supplementation on growth performance and plasma minerals and metabolites in hair lambs grazing Panicum maximum
Authors: MARTÍNEZ MANUEL , GASPERÍN ISAAC DE , VICENTE JORGE , PINOS-RODRÍGUEZ JUAN
Published: December 2020

Forty-eight hair lambs (12.7 ± 1.9 kg BW) that grazed Panicum maximum pasture in the daytime and were kept in yards overnight were used to evaluate the influence of a feed supplement on growth performance, plasma minerals and metabolites. Lambs were randomly assigned to two treatments: no feed supplement (control) and feed supplement (300 g/head per day). The growth performance trial lasted 77 days. At the end of the trial, blood samples were collected to determine plasma minerals and metabolites. Feed supplementation improved total BW gain, ADG and feed conversion as compared to no supplementation. Supplemented lambs had higher serum concentrations of total protein, albumin, globulin and glucose than lambs not supplemented. Packed blood cell volume, haemoglobin, urea and cholesterol, as well as blood mineral values in lambs not supplemented were similar to those of supplemented lambs. Feed supplementation of growing lambs grazing pasture in the daytime and kept in yards overnight is an important management strategy for improving growth performance and some blood metabolites related to health and nutritional status.
Agreement between ECG values obtained in the sternal recumbent position and right lateral recumbency in goats
Authors: SZALUŚ-JORDANOW OLGA , CZOPOWICZ MICHAŁ , SZPINDA OKTAWIA , MICKIEWICZ MARCIN , MOROZ AGATA , KABA JAROSŁAW , GARNCARZ MAGDALENA , FRYMUS TADEUSZ
Published: December 2020

The aim of the study was to analyze if body positioning during electrocardiogram recording has an influence on the results in goats. Forty-seven Polish White Improved and Polish Fawn Improved goats from a large dairy herd selected for sanitary culling due to caprine arthritis-encephalitis virus (CAEV) infection, ranging from 2-12 years (median 5.5 years) were included in the study. ECG records were obtained from each goat in the sternal recumbent position and in right lateral recumbency using ASPEL AsCARD Mr. Silver machine with a frequency range of 0.05-150 Hz. The signals from leads I, II, III, aVR, aVL and aVF were recorded for 30 seconds. The mean values of P, QRS, T, PQ, QT, P-R duration (in sec) and P, Q, R, S, T waves amplitude (mV) were measured and analyzed. Values obtained in both positions did not differ significantly.
AROMA PROFILE AND PHENOLIC CONTENT OF MERLOT RED WINES PRODUCED IN HIGH-ALTITUDE REGIONS IN BRAZIL
Authors: Arcari Stefany , Caliari Vinícius , Souza Edson , Godoy Helena
Published: December 2020

In Brazil, wine-growing regions of high altitude have been evaluated for the cultivation of grapes destined for the production of quality wines. In this study the phenolic content, the volatile compounds profile and the in vitro antioxidant activity of samples produced in Água Doce, Campos Novos and Tangará were determined using spectrophotometric and chromatographic techniques. A total of 95 volatile compounds were identified in the samples analyzed, of which borneol is reported in Brazilian Merlot wines for the first time. The quantitative results showed that the most important volatile compounds for wine aroma were esters, fatty acids, 1-hexanol and 2-phenylethanol alcohols, and C13-norisoprenoids β-damascenone and α-ionone. The phenolic content observed was comparable to the results obtained for Merlot red wines from other regions in Brazil and in other countries. Also, the wine samples were effective in capturing the free radicals DPPH and ABTS.
Eksplorasi Lumut (Bryophyta) di Kawasan Air Terjun Bukit Gatan Provinsi Sumatera Selatan
Authors: Utami Febri Yulia , Harmoko Harmoko , Fitriani Linna
Published: December 2020

This study aims to determine the type of moss in the Bukit Gatan Waterfall Region of Ulu Terawas STL Musi Rawas Regency, as well as Abiotic Factors in the Bukit Gatan Waterfall Area in the District of Ulu Terawas STL Musi Rawas District. This research is descriptive Descriptive: direct observation in the location of the Bukit Gatan Waterfall Area, STL Ulu Terawas Musi Rawas Regency with a roaming method or exploring the Waterfall Area. Data were analyzed descriptively qualitatively. Types of moss found in 2 Classes namely Bryopsida and Hepaticopsida, consisting of 5 Orders namely Pottiales, Bryales, Fissidentales, Hypnales, and Jungermaniales, consisting of 5 Families namely Pottiaceae, Batramiaceae, Fissidentaceae, Hypnaceae and Plagiochilaceae, consisting of 6 Genus Hyophila, Philotiphll, Philotropll , and Plagiochila, consisting of 7 species namely Hyophila javanica, Philonotis hastata, Fissidens atroviridis, Hyophila apiculata, Ectropothecium sp., Taxiphyllum sp., and Plagiochila asplenoides. The Abioic Factor is pH Temperature which is an average of 6.6, temperatures with an average of 27 ºC, humidity with an average of 6.3% and at an appropriate light intensity of 285lux.