bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Addition of a Thallium Vertex to Empty and Centered Nine‐Atom Deltahedral Zintl Ions of Germanium and Tin.
Authors: Rios Daniel , Gillett‐Kunnath Miriam M. , Taylor Jacob D. , Oliver Allen G. , Sevov Slavi C.
Published: April 2011

The empty and Ni‐centered Ge9 and Sn9 clusters react with TlCp and add a tenth Tl‐vertex to form bicapped square antiprismatic closo‐clusters [M9Tl]3‐ (M: Ge, Sn) and [Ni@M9Tl]3‐.
ChemInform Abstract: U(VI) Uranyl Cation—Cation Interactions in Framework Germanates.
Authors: Morrison Jessica M. , Moore‐Shay Laura J. , Burns Peter C.
Published: April 2011

The isomorphous uranyl germanates (IV), (VI) and (VIII) crystallize in the trigonal space group P$\bar 3$1c with Z = 2 (single crystal XRD).
ChemInform Abstract: Role of Anions and Reaction Conditions in the Preparation of Uranium(VI), Neptunium(VI), and Plutonium(VI) Borates.
Authors: Wang Shuao , Villa Eric M. , Diwu Juan , Alekseev Evgeny V. , Depmeier Wulf , Albrecht‐Schmitt Thomas E.
Published: April 2011

Compounds (III), (V), and (VII) are characterized by single crystal XRD, UV/VIS/NIR and fluorescence spectroscopy.
ChemInform Abstract: Buckled Layers in K0.66Mn2O4·0.28H2O and K0.99Mn3O6·1.25H2O Synthesized at High Pressure: Implication for the Mechanism of Layer‐to‐Tunnel Transformation in Manganese Oxides.
Authors: Chu Qingxin , Wang Xiaofeng , Zhang Xinhao , Li Qiliang , Liu Xiaoyang
Published: April 2011

K0.66Mn2O4·0.28H2O (I) is synthesized by reaction of MnO2 in a KOH flux (Pt tube, 50 MPa, 550 °C, 12 h).
ChemInform Abstract: Novel Polyselenidoarsenate and Selenidoarsenate: Solvothermal Synthesis and Characterization of [Co(phen)3] [As2Se2(μ‐Se3)(μ‐Se5)] and [Co(phen)3]2[As8Se14].
Authors: Zhao Jing , Liang Jingjing , Chen Jiangfang , Pan Yingli , Zhang Yong , Jia Dingxian
Published: April 2011

The structures of title compounds (III) (monoclinic, space group C2, Z = 4) and (IV) (triclinic, P$\bar 1$, Z = 1) are determined by single crystal XRD.
ChemInform Abstract: A Cagelike Polyanion with a Ag+ Enwrapped, [AgAs2Mo15O54]11‐.
Authors: Zhang Yanping , Li Lili , Sun Tao , Liu Bin , Hu Huaiming , Xue Ganglin
Published: April 2011

The salts (IV) and (V) of the title anion crystallize in the orthorhombic space group Pnma with Z = 4 (single crystal XRD).
ChemInform Abstract: Disulfonimide‐Catalyzed Asymmetric Vinylogous and Bisvinylogous Mukaiyama Aldol Reactions.
Authors: Ratjen Lars , Garcia‐Garcia Pilar , Lay Frank , Beck Michael Edmund , List Benjamin
Published: April 2011

The present new disulfonimide catalyzed vinylogous Mukaiyama aldol addition of crotonic acid derivatives (I) to aldehydes can also be applied to ketene acetal nucleophiles (IV).
ChemInform Abstract: Synthesis of Enantiopure 1,4‐Dioxanes, Morpholines, and Piperazines from the Reaction of Chiral 1,2‐Diols, Amino Alcohols, and Diamines with Vinyl Selenones.
Authors: Bagnoli Luana , Scarponi Catalina , Rossi Maria Giovanna , Testaferri Lorenzo , Tiecco Marcello
Published: April 2011

The reaction of enantiopure diols, amino alcohols, or diamines with vinyl selenones in the presence of NaH represents a novel route to the title compounds.
ChemInform Abstract: Catalytic Asymmetric α‐Alkylation of Aldehydes via a SN2′‐Type Addition—Elimination Pathway.
Authors: Gomez‐Bengoa Enrique , Landa Aitor , Lizarraga Aitziber , Mielgo Antonia , Oiarbide Mikel , Palomo Claudio
Published: April 2011

An amine‐catalyzed α‐alkylation of aldehydes is described.
ChemInform Abstract: Iodoamidation of Olefins with Chloramine Salts and Iodine in Aqueous Media.
Authors: Minakata Satoshi , Hayakawa Junpei
Published: April 2011

A new and convenient method for the efficient iodoamination of olefins in aqueous medium is developed.
ChemInform Abstract: Azomethine Ylide Annulations: Facile Access to Polycyclic Ring Systems.
Authors: Zhang Chen , Das Deepankar , Seidel Daniel
Published: April 2011

New 1,6‐annulation reactions of azomethine ylides are reported.
ChemInform Abstract: A General Procedure for the Synthesis of Enones via Gold‐Catalyzed Meyer—Schuster Rearrangement of Propargylic Alcohols at Room Temperature.
Authors: Pennell Matthew N. , Unthank Matthew G. , Turner Peter , Sheppard Tom D.
Published: April 2011

In the presence of [Au(PPh3)]NTf2 and MeOH or 4‐methoxyphenylboronic acid, propargylic alcohols undergo convenient rearrangement to enones.
ChemInform Abstract: The Nonmetathetic Role of Grubbs′ Carbene Complexes: From Hydrogen‐Free Reduction of α,β‐Unsaturated Alkenes to Solid‐Supported Sequential Cross‐Metathesis/Reduction.
Authors: Poeylaut‐Palena Andres A. , Testero Sebastian A. , Mata Ernesto G.
Published: April 2011

A microwave‐induced reduction of alkenes (I), (III), and (V) with triethylsilane proceeds readily in the presence of Grubbs′ II catalyst.
ChemInform Abstract: Gold‐Complexes Catalyzed Oxidative α‐Cyanation of Tertiary Amines.
Authors: Zhang Yan , Peng Hao , Zhang Ming , Cheng Yixiang , Zhu Chengjian
Published: April 2011

The first examples for the direct oxidative cyanation of tertiary amines catalyzed by a gold catalyst are given.
ChemInform Abstract: Palladium‐Catalyzed Novel Arylations of Cyclic β‐Bromo α,β‐Unsaturated Aldehydes with Triarylbismuths as Multicoupling Organometallic Nucleophiles.
Authors: Rao Maddali L. N. , Banerjee Debasis , Dhanorkar Ritesh J.
Published: April 2011

An efficient method is presented for the Pd‐catalyzed cross‐coupling of cyclic bromoalkenes with triarylbismuths to afford the corresponding aryl derivatives.
ChemInform Abstract: A Chiral Rh‐Phosphite Complex Dislaying High Activity in the Enantioselective Rh‐Catalyzed Addition of Arylboronic Acids to Carbonyl Compounds: When and Why atropos Is Better Than tropos.
Authors: Jumde Varsha R. , Facchetti Sarah , Iuliano Anna
Published: April 2011

The rhodium/deoxycholic acid complex bearing the atropoisomeric (S)‐binaphthyl moiety is shown to catalyze the asymmetric addition of arylboronic acids to aldehydes (I) or the challenging ketone (IV).
ChemInform Abstract: Indolinylmethanol Catalyzed Enantioselective Reformatsky Reaction with Ketones.
Authors: Lin Ning , Chen Miao‐Miao , Luo Ren‐Shi , Deng Yan‐Qiu , Lu Gui
Published: April 2011

The enantioselective Reformatzky reaction of an α‐bromo ester with various ketones is developed using NiBr2 and a chiral indolinylmethanol ligand as catalyst.
ChemInform Abstract: Cooperative Catalytic Reactions Using Organocatalysts and Transition Metal Catalysts: Enantioselective Propargylic Alkylation of Propargylic Esters with Aldehydes.
Authors: Yoshida Akiko , Ikeda Masahiro , Hattori Gaku , Miyake Yoshihiro , Nishibayashi Yoshiaki
Published: April 2011

In the presence of CuOTf, BINAP, and the prolinol (PRO) propargylic esters are found to undergo highly enantioselective reaction with aldehydes to afford alcohols like (III), (IV), (VI), and (VII).
ChemInform Abstract: Convergent Synthesis of Functionalized Fluoroallylamines by the Julia—Kocienski Reaction.
Authors: Calata Charlene , Pfund Emmanuel , Lequeux Thierry
Published: April 2011

Amino sulfones are used as precursors in the synthesis of functionalized flouroallylamines.
ChemInform Abstract: Palladium‐Catalyzed Addition of Alkynes to Cyclopropenes: An Entry to Stereodefined Alkynylcyclopropanes.
Authors: Tenaglia Alphonse , Le Jeune Karel , Giordano Laurent , Buono Gerard
Published: April 2011

The Herrmann—Beller phosphapalladacycle catalyzes the reaction at room temperature without addition of any base.
ChemInform Abstract: Autoxidative Annulation Cascade of the α‐Cyano β‐TMS‐Capped Alkynyl Cycloalkanone System.
Authors: Wong Ying‐Chieh , Hsieh Min‐Tsang , Amancha Prashanth K. , Chin Chih‐Lung , Liao Cheng‐Feng , Kuo Chun‐Wei , Shia Kak‐Shan
Published: April 2011

The presence of the trimethylsilyl moiety and a cyano group are essential for the annulation as no autooxidative cyclization takes place using the terminal alkyne (XI) or ester (XII).
ChemInform Abstract: Room Temperature Aryl Trifluoromethylation via Copper‐Mediated Oxidative Cross‐Coupling.
Authors: Senecal Todd D. , Parsons Andrew T. , Buchwald Stephen L.
Published: April 2011

Under the mild conditions, a wide range of trifluoromethylated arenes and heteroarenes is available.
ChemInform Abstract: Structure—Enantioselectivity Effects in 3,4‐Dihydropyrimido[2,1‐b]‐benzothiazole‐Based Isothioureas as Enantioselective Acylation Catalysts.
Authors: Smith Andrew D. , et al. et al.
Published: April 2011

An isothiourea catalyst is developed for the kinetic resolution of a variety of secondary aromatic alcohols using low catalyst loading (0.1—0.25 mol%).
ChemInform Abstract: Highly Enantioselective Henry Reactions in Water Catalyzed by a Copper Tertiary Amine Complex and Applied in the Synthesis of (S)‐N‐trans‐Feruloyl Octopamine.
Authors: Lai Guoyin , Guo Fengfeng , Zheng Yueqin , Fang Yang , Song Haigang , Xu Kun , Wang Sujing , Zha Zhenggen , Wang Zhiyong
Published: April 2011

Asymmetric Henry reaction of nitromethane with a diversity of aromatic or aliphatic aldehydes proceeds efficiently in water under phase‐transfer catalysis conditions with a Cu(II)—prolinol‐derived tridentate ligand complex.
ChemInform Abstract: Facile Synthesis of Hydroxyformamidines by the N‐Oxidation of Their Corresponding Formamidines.
Authors: Cibian Mihaela , Langis‐Barsetti Sophie , Hanan Garry S.
Published: April 2011

Improved reaction conditions are developed for the synthesis of formamidines (III).
ChemInform Abstract: Cu‐Catalyzed One‐Pot Synthesis of Unsymmetrical Diaryl Thioethers by Coupling of Aryl Halides Using a Thiol Precursor.
Authors: Prasad D. J. C. , Sekar Govindasamy
Published: April 2011

The new and efficient method can also be applied successfully to the synthesis of symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles.
ChemInform Abstract: Ni‐Catalyzed Intramolecular Cycloaddition of Methylenecyclopropanes to Alkynes.
Authors: Yao Bangben , Li Yong , Liang Zunjun , Zhang Yuhong
Published: April 2011

The process allows a facile access to a broad spectrum of cyclopenta[a]indene structures including derivatives which are suitable for further functionalization [cf.
ChemInform Abstract: Argentic Oxide Mediated N‐Dearylation of β‐Lactams.
Authors: Zarei Maaroof , Jarrahpour Aliasghar
Published: April 2011

The use of AgO allows a simple and efficient process which affords, compared to CAN, similar yields within a shorter time (10 min versus 45 min).
ChemInform Abstract: Organic Iron for the PdCl2/FeCl3‐Cocatalyzed Coupling Cyclization of 2,3‐Allenoates in the Presence of Allylic Bromides.
Authors: Chen Bo , Ma Shengming
Published: April 2011

The method gives access to β‐allylic substituted butenolides by use of FeCl3 as cocatalyst of PdCl2.
ChemInform Abstract: New Strategy for the Synthesis of N‐Aryl Pyrroles: Cu‐Catalyzed C—N Cross‐Coupling Reaction of trans‐4‐Hydroxy‐L‐proline with Aryl Halides.
Authors: Reddy V. Prakash , Kumar A. Vijay , Rao K. Rama
Published: April 2011

It is demonstrated that amino acid (I) is an efficient nucleophilic coupling partner in the reaction with aryl iodides and bromides.
ChemInform Abstract: The Vinyl Moiety as a Handle for Regiocontrol in the Preparation of Unsymmetrical 2,3‐Aliphatic‐Substituted Indoles and Pyrroles.
Authors: Huestis Malcolm P. , Chan Lina , Stuart David R. , Fagnou Keith
Published: April 2011

Rh‐catalyzed reactions of anilides (I) or methyl‐2‐acetamidoacrylate (VI) with various enynes proceed with excellent regioselectivity to furnish 2‐alkenyl indoles and pyrroles, respectively.
ChemInform Abstract: A Silver‐Promoted Auto‐Tandem Catalysis for the Synthesis of Multiply Substituted Tetrahydrocarbazoles.
Authors: Wang Ming‐Zhong , Zhou Cong‐Ying , Che Chi‐Ming
Published: April 2011

Silver(I) triflate promotes the reaction of acetylenic aldehydes with various indole derivatives to give the title compounds as diastereomeric mixtures.
ChemInform Abstract: An Efficient Synthesis of Pyrazole Chalcones under Solvent‐Free Conditions at Room Temperature.
Authors: Kumar Parvin , Kumar Sunil , Husain Khalid , Kumar Ashwani
Published: April 2011

Simply grindig of pyrazole aldehydes with acetophenones in the presence of activated Ba(OH)2 results in formation of pyrazole‐substituted chalcones.
ChemInform Abstract: Asymmetric α‐Amination of 4‐Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,N′‐Dioxide Complex: Highly Enantioselective Synthesis of 4‐Amino‐5‐pyrazolone Derivatives.
Authors: Yang Zhigang , Wang Zhen , Bai Sha , Liu Xiaohua , Lin Lili , Feng Xiaoming
Published: April 2011

With only 0.05 mol% of catalyst loading [cf.(VII)], the reaction proceeds without obvious influence on reactivity and enantioselectivity, albeit with a somewhat prolonged reaction time.
ChemInform Abstract: The Convenient Synthesis of 4‐Arylmethylidene‐4,5‐dihydro‐3‐phenylisoxazol‐5‐ones.
Authors: Ablajan Keyume , Xiamuxi Hainimu
Published: April 2011

The one‐pot synthesis of title compounds (III) involves formation of 3‐phenylisoxazolone (IV) and subsequent reaction with aldehydes in one‐pot.
ChemInform Abstract: Synthesis and in Vitro Cytotoxic Evaluation of Some Thiazolylbenzimidazole Derivatives.
Authors: Luo Yu , Xiao Feng , Qian Shijing , Lu Wei , Yang Bo
Published: April 2011

The novel title derivatives are synthesized in order to test their in vitro antitumor activity against SMMC‐7721 and A549 cell lines in comparison to taxol.
ChemInform Abstract: Enantioselective Organocatalytic Domino Michael—Acetalization—Henry Reactions of 2‐Hydroxynitrostyrene and Aldehyde for the Synthesis of Tetrahydro‐6H‐benzo[c]chromenones.
Authors: Hong Bor‐Cherng , Kotame Prakash , Liao Ju‐Hsiou
Published: April 2011

Comparable results are obtained using ethanol or pure water as a solvent with the latter having an advantage of shorter reaction times.
ChemInform Abstract: Regiocontrolled Preparation of 3‐Acyl‐6‐aryl‐2‐pyridones via Condensation of 3‐Aryl‐3‐chloropropeniminium Salts with β‐Keto‐amides.
Authors: Gmiza Thouraya , Ayed Mohamed Adnen Hadj , Khiari Jamel Eddine , Ben Hassine Bechir
Published: April 2011

The advantages are a simple reaction procedure and high yields.
ChemInform Abstract: n‐Butyltriphenylphosphonium Peroxodisulfate: A Cheap and Efficient Reagent for the Aromatization of Hantzsch 1,4‐Dihydropyridines.
Authors: Gorjizadeh Maryam , Abdollahi‐Alibeik Mohammad
Published: April 2011

Various substrates are successfully oxidized to the corresponding pyridines using the title reagent as oxidant in refluxing acetonitrile.
ChemInform Abstract: Synthesis of Substituted 8‐Aminoquinolines and Phenanthrolines Through a Povarov Approach.
Authors: De Kavita , Legros Julien , Crousse Benoit , Chandrasekaran Srinivasan , Bonnet‐Delpon Daniele
Published: April 2011

A Povarov/oxidation sequence is used to prepare a variety of 8‐aminoquinolines.
ChemInform Abstract: Ruthenium‐Catalyzed Synthesis of 2‐ and 3‐Substituted Quinolines from Anilines and 1,3‐Diols.
Authors: Monrad Rune Nygaard , Madsen Robert
Published: April 2011

Complete regioselectivity is observed in the reaction with 1‐substituted diols affording 2‐substituted quinolines exclusively.
ChemInform Abstract: Iridium‐Catalyzed Asymmetric Intramolecular Allylic Amidation: Enantioselective Synthesis of Chiral Tetrahydroisoquinolines and Saturated Nitrogen Heterocycles.
Authors: Teichert Johannes F. , Fananas‐Mastral Martin , Feringa Ben L.
Published: April 2011

An iridium catalyst is used for the first time for the synthesis of chiral tetrahydroisoquinolines.
ChemInform Abstract: Amine Directed Pd(II)‐Catalyzed C—H Bond Functionalization under Ambient Conditions.
Authors: Haffemayer Benjamin , Gulias Moises , Gaunt Matthew J.
Published: April 2011

The Pd‐catalyzed C—H bond functionalization of β‐arylethylamines proceeds under mild conditions and allows C—H carbonylation, C—H arylation, and C—H amination.
ChemInform Abstract: The Tertiary Amino Effect: An Efficient Method for the Synthesis of α‐Carbolines.
Authors: Majumder Swarup , Bhuyan Pulak J.
Published: April 2011

A facile synthesis of α‐carbolines based on the cyclization of tertiary amines (IX) is given.
ChemInform Abstract: Synthesis of Chromeno[3,4‐b]quinolines: Electrophilic Aromatic Substitution under Heck Conditions.
Authors: Morris Andrew L. C. , Jackson Yvette A.
Published: April 2011

Electron‐donating groups on the phenoxy ring of substrates (I) increase the rate of cyclization reactions, whereas deactivating substituents such formyl and nitro inhibit the process.
ChemInform Abstract: Synthesis of 1‐Substituted 1,2,3,4‐Tetrahydrobenz[g]isoquinoline‐5,10‐diones.
Authors: Shinkevich Ekaterina , Deblander Jurgen , Matthijs Sandra , Jacobs Jan , De Kimpe Norbert , Abbaspour Tehrani Kourosch
Published: April 2011

The novel synthesis of N‐acyl substituted isoquinoline derivatives (III) through the activated Pictet—Spengler reaction has to be carried out in the presence of AlCl3.
ChemInform Abstract: Nitrogen Heteroaromatic Cations by [2 + 2 + 2] Cycloaddition.
Authors: Cizkova Martina , Kolivoska Viliam , Cisarova Ivana , Saman David , Pospisil Lubomir , Teply Filip
Published: April 2011

A variety of fused heterocyclic cations is prepared in the reaction with the gaseous acetylene, catalyzed by rhodium or irridium complexes.
ChemInform Abstract: Supramolecular Synthesis of 3,4‐Dihydropyrimidine‐2(1H)‐one/thiones under Neat Conditions.
Authors: Asghari Sekineh , Tajbakhsh Mahmood , Kenari Behnam Jafarzadeh , Khaksar Samad
Published: April 2011

Sulfonylated β‐cyclodextrin is found to be an efficient heterogeneous catalyst for the three‐component reaction.
ChemInform Abstract: Convergent Assembly of Structurally Diverse Quinazolines.
Authors: Crespo Abel , Coelho Alberto , Diz Paula M. , Fernandez Franco , Novoa de Armas Hector , Sotelo Eddy
Published: April 2011

The Vilsmeier—Haack‐based carboannulation strategy is applied to prepare a variety of different halogenated quinazoline derivatives, strongly dependent on the N‐substitution and reaction temperature.
ChemInform Abstract: First Example of Quinoxaline‐Directed C—H Activation: A Novel Method for Acetoxylation of Arenes.
Authors: Reddy B. V. Subba , Ramesh K. , Yadav J. S.
Published: April 2011

Iodosobenzene diacetate and palladium acetate as the catalyst are used for the regioselective acetoxylation of phenyl substituted quinoxaline derivatives.
ChemInform Abstract: Synthesis and Activity of Novel 1‐Halogenobenzylindole Linked Triazole Derivatives as Antifungal Agents.
Authors: Na Young Min
Published: April 2011

A variety of the title triazole derivatives (I) (33 examples), analogues of voriconazole, is synthesized and evaluated for antifungal activities.
ChemInform Abstract: Efficient Synthesis of [1,3]Oxazino[3,2‐f]phenanthridine Derivatives by a Novel 1,4‐Dipolar Cycloaddition Involving a Phenanthridine—Dimethyl Acetylenedicarboxylate Zwitterion and Aromatic Aldehydes.
Authors: Li Ming , Pan Lei , Wen Li‐Rong
Published: April 2011

The multicomponent procedure allows the regioselective synthesis of the title skeleton under mild conditions.
ChemInform Abstract: One‐Pot Syntheses of 2‐(2‐Sulfanyl‐4H‐3,1‐benzothiazin‐4‐yl)acetic Acid Derivatives via Reactions of 3‐(2‐Isothiocyanatophenyl)prop‐2‐enoic Acid Derivatives with Thiols or Sodium Sulfide.
Authors: Fukamachi Shuhei , Konishi Hisatoshi , Kobayashi Kazuhiro
Published: April 2011

Title compounds can be synthesized by two different pathways.
ChemInform Abstract: Facile Route for Novel Quinazolinone‐Fused Azauracils Through Cyclodesulfurization of Thioquinazolinones.
Authors: Kale Raju R. , Prasad Virendra , Tiwari Vinod K.
Published: April 2011

Thioquinazolinones react with two equivalents of silver cyanate to give quinazoline‐fused azauracils via a cyclodesulfurization process.
ChemInform Abstract: Expeditious Entry to Enantiopure Mono‐ and Bis(tricyclic) β‐Lactams by Single or Double [2 + 2] Cycloaddition of Allenynes.
Authors: Alcaide Benito , Almendros Pedro , Aragoncillo Cristina , Gomez‐Campillos Gonzalo
Published: April 2011

Thermal cycloaddition of β‐lactam‐tethered allenynes, e.g. (III), provides access to structurally novel tricyclic β‐lactams containing a seven‐membered ring and a strained cyclobutene ring.
ChemInform Abstract: Polyethylene Glycol (PEG‐400): An Efficient and Recyclable Reaction Medium for the Synthesis of Novel 1; 5‐Benzodiazepines and Their Antimicrobial Activity.
Authors: Konda Shankaraiah G. , Shaikh Baseer M. , Chavan Sanjay A. , Dawane Bhaskar S.
Published: April 2011

Condensation of o‐phenylenediamine with chalcones (II) provides the target compounds (12 examples) which are evaluated for antifungal and antibacterial activity.
ChemInform Abstract: Benzoylureas as Removable cis Amide Inducers: Synthesis of Cyclic Amides via Ring Closing Metathesis (RCM).
Authors: Brady Ryan M. , Khakham Yelena , Lessene Guillaume , Baell Jonathan B.
Published: April 2011

The benzoylurea auxiliary in (I) and (IV) facilitate the formation of macrocyclic lactams via stabilization of a cisoid amide bond, promoting rapid and high yielding ring closure via ring closing metathesis.
ChemInform Abstract: A New Method for the Synthesis of Dichlorophosphines.
Authors: Tavtorkin Alexander N. , Toloraya Sofia A. , Nifant'ev Eduard E. , Nifant'ev Ilya E.
Published: April 2011

Reaction of alkyl and aryl phosphines with PCl5 provides a simple synthesis of the target compounds.
ChemInform Abstract: Crocipodin (I), a Benzotropolone Pigment from the Mushroom Leccinum crocipodium (Boletales).
Authors: Kerschensteiner Lydia , Loebermann Florian , Steglich Wolfgang , Trauner Dirk
Published: April 2011

isolation, structure elucidation and synthesis
ChemInform Abstract: Cytotoxic and Protective DNA Damage of Three New Diterpenoids from the Brown Alga Dictoyota dichotoma.
Authors: Ayyad Seif‐Eldin N. , Makki Mohamed S. , Al‐kayal Nazeeha S. , Basaif Salim A. , El‐Foty Kalid O. , Asiri Abdullah M. , Alarif Walied M. , Badria Farid A.
Published: April 2011

The biological activity of compounds (I) is relatively high in all types of assays (bleomycin‐dependent DNA damage, cytotoxicity against WI‐38, HepG2, MCF‐7 cells and antioxidant activity).
ChemInform Abstract: Antioxidant Activity of a New C‐Glycosylflavone from the Leaves of Ficus microcarpa.
Authors: Kim Young Ho , et al. et al.
Published: April 2011

The bioactive‐guided fractionation of the methanol extract of F.microcarpa leaves furnishes one new C‐glycosylflavone, ficuflavoside (I), one new megastigmane glycoside, ficumegasoside (II), and twelve known compounds including flavonoids, phenylpropanoids, megastigmanes and sterol derivatives.
ChemInform Abstract: The Pd‐Catalyzed Alder‐Ene Reactions of N‐Protected and Propargylated 1‐Amino‐2‐aryl‐2‐cyclohexenes as a New Route to C3a‐Arylhexahydroindoles: Towards the Total Synthesis of Tazettine.
Authors: Lehmann Anna L. , Willis Anthony C. , Banwell Martin G.
Published: April 2011

A series of N‐protected and propargylated 1‐amino‐2‐arylcyclohex‐2‐enes is prepared on routes similar to that described for (V).
ChemInform Abstract: Bafilomycins Produced by an Endophytic Actinomycete Streptomyces sp. YIM56209
Authors: Yu Zhiguo , Zhao Li‐Xing , Jiang Cheng‐Lin , Duan Yanwen , Wong Lily , Carver Kristopher C. , Schuler Linda A. , Shen Ben
Published: April 2011

isolation, structure determination and cytotoxicity of two new bafilomycins, 9‐hydroxybafilomycin D (Ia) and 29‐hydroxybafilomycin D (Ib), together with nine known bafilomycins
ChemInform Abstract: Cycloheximide and Congeners as Inhibitors of Eukaryotic Protein Synthesis from Endophytic Actinomycetes Streptomyces sps. YIM56132 and YIM56141.
Authors: Huang Sheng‐Xiong , Yu Zhiguo , Robert Francis , Zhao Li‐Xing , Jiang Yi , Duan Yanwen , Pelletier Jerry , Shen Ben
Published: April 2011

[isolation, structure and activity of two new cycloheximide congeners, i.e.
ChemInform Abstract: Aspergilones A and B, Two Benzylazaphilones with an Unprecedented Carbon Skeleton from the Gorgonian‐Derived Fungus Aspergillus sp.
Authors: Shao Chang‐Lun , Wang Chang‐Yun , Wei Mei‐Yan , Gu Yu‐Cheng , She Zhi‐Gang , Qian Pei‐Yuan , Lin Yong‐Cheng
Published: April 2011

Aspergilone A(I) possessing an azaphilone structure, and its symmetrical dimer with a unique methylene bridge, aspergilone B(II), are isolated from the culture broth of the marine derived title plant.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Dihydro‐aryl/alkylsulfanyl‐cyclohexylmethyl‐oxopyrimidines (S‐DACOs) as High Active anti‐HIV Agents.
Authors: He Yan‐Ping , et al. et al.
Published: April 2011

A combinatory library of title compounds is designed by exploring the effect of the 6‐cyclohexyl moiety in the 4‐pyrimidinone series on the anti HIV‐1 activity.
ChemInform Abstract: Discovery of a Novel Nitroimidazolyl—Oxazolidinone Hybrid with Potent anti Gram‐Positive Activity: Synthesis and Antibacterial Evaluation.
Authors: Foroumadi Alireza , et al. et al.
Published: April 2011

Among the three investigated compounds, (Ic) exhibits the most promising activity against Gram‐positive bacteria at non‐cytotoxic concentrations.
ChemInform Abstract: Synthesis and in vitro Antimycobacterial Activity of 8‐OCH3 Ciprofloxacin Methylene and Ethylene Isatin Derivatives.
Authors: Feng Lian‐Shun , Liu Ming‐Liang , Zhang Shu , Chai Yun , Wang Bo , Zhang Yi‐Bin , Lv Kai , Guan Yan , Guo Hui‐Yuan , Xiao Chun‐Ling
Published: April 2011

A series of novel 8‐OMe ciprofloxacin methylene and ethylene isatin derivatives (I) with remarkable improvement in lipophilicity are synthesized and evaluated for their in vitro activity against some mycobacteria.
ChemInform Abstract: Antiproliferative Activity of Phenylbutyrate Ester of Haloperidol Metabolite II [(.+‐.)‐MRJF4] in Prostate Cancer Cells.
Authors: Marrazzo Agostino , Fiorito Jole , Zappala Laura , Prezzavento Orazio , Ronsisvalle Simone , Pasquinucci Lorella , Scoto Giovanna M. , Bernardini Renato , Ronsisvalle Giuseppe
Published: April 2011

MRJF4 (I) inhibits cell growth in the prostate cancer cell lines LNCaP and PC3.
ChemInform Abstract: Modulation of PPAR Subtype Selectivity. Part 2. Transforming PPARα/γ Dual Agonist into α Selective PPAR Agonist Through Bioisosteric Modification.
Authors: Bahekar Rajesh , et al. et al.
Published: April 2011

Bioisosteric replacement of the rigid oxazole ring of a previously reported PPARα/γ dual agonist with a flexible lipophilic tail leads to a series of oxime containing benzyl dioxanecarboxylic acid derivatives.
ChemInform Abstract: Mechanism of Formation of Perovskite‐Type Layered Oxides
Authors: Zvereva Irina A. , Missyul Alexander B.
Published: April 2011

Review: 85 refs.
ChemInform Abstract: Theoretical View on the Origin and Implications of Structural Distortions in Polyoxometalates
Authors: Lopez Xavier , Vila‐Nadal Laia , Aparicio‐Angles Xavier , Poblet Josep M.
Published: April 2011

Review: 50 refs.
ChemInform Abstract: Synthesis of Saturated Five‐Membered Nitrogen Heterocycles via Pd‐Catalyzed C—N Bond‐Forming Reactions
Authors: Wolfe John P. , Neukom Joshua D. , Mai Duy H.
Published: April 2011

Review: 233 refs.
ChemInform Abstract: Schmidt Reaction of Flavanone Derivatives: Synthesis of Benzoheterazepine Derivatives
Authors: Mphahlele Malose J.
Published: April 2011

Review: 33 refs.
ChemInform Abstract: Transition Metal Catalyzed Synthesis of Monocyclic Five‐Membered Aromatic Heterocycles
Authors: Dudnik Alexander S. , Gevorgyan Vladimir
Published: April 2011

Review: 318 refs.
ChemInform Abstract: Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products
Authors: Bringmann Gerhard , Gulder Tanja , Gulder Tobias A. M. , Breuning Matthias
Published: April 2011

Review: 564 refs.
ChemInform Abstract: Naphthalene Derivatives: A New Range of Antimicrobial Agents with High Therapeutic Value
Authors: Rokade Y. B. , Sayyed R. Z.
Published: April 2011

Review: 23 refs.
ChemInform Abstract: Supramolecular Complexes Based on Cyclodextrins
Authors: Chernykh E. V. , Brichkin S. B.
Published: April 2011

Review: 102 refs.
ChemInform Abstract: Effective Supramolecular Chirogenesis in Ethane‐Bridged Bis‐porphyrinoids
Authors: Borovkov Victor
Published: April 2011

Review: 39 refs.
ChemInform Abstract: Gold‐Catalyzed Addition of Nitrogen and Sulfur Nucleophiles to C—C Multiple Bonds
Authors: Widenhoefer Ross A. , Song Feijie
Published: April 2011

Review: 71 refs.
ChemInform Abstract: Rhodium‐Catalyzed C—H Aminations
Authors: Lebel Helene
Published: April 2011

Review: 77 refs.
ChemInform Abstract: Synthetic Methods. Part 1. Free‐Radical Reactions
Authors: Rowlands Gareth J.
Published: April 2011

Review: 51 refs.
ChemInform Abstract: Organocatalysis
Authors: Buckley Benjamin R. , Neary Stephen P.
Published: April 2011

Review: 44 refs.
ChemInform Abstract: Ionic Liquids and Dense Carbon Dioxide: A Beneficial Biphasic System for Catalysis
Authors: Jutz Fabian , Andanson Jean‐Michel , Baiker Alfons
Published: April 2011

Review: 244 refs.
ChemInform Abstract: Oxoammonium Salt Oxidations of Alcohols
Authors: Bobbitt James M.
Published: April 2011

Review: 64 refs.
ChemInform Abstract: Aliphatic Aldehydes in the Synthesis of Carbo‐ and Heterocycles. Part 1. Synthesis of Three‐, Four‐, and Five‐Membered Rings
Authors: Dyachenko V. D. , Karpov E. N.
Published: April 2011

Review: data published over the last 12 years are summarized and systematized; 177 refs.
ChemInform Abstract: Novel Triptycene‐Derived Hosts: Synthesis and Their Applications in Supramolecular Chemistry
Authors: Chen Chuan‐Feng
Published: April 2011

Review: 59 refs.
ChemInform Abstract: The Chemistry of D3‐Trishomocubane
Authors: Levandovsky I. A. , Sharapa D. I. , Cherenkova O. A. , Gaidai A. V. , Shubina T. E.
Published: April 2011

Review: 89 refs.
ChemInform Abstract: Organoiodine(V) Reagents in Organic Synthesis
Authors: Zhdankin Viktor V.
Published: April 2011

Review: 208 refs.
ChemInform Abstract: Secondary Metabolites of Fungi from Marine Habitats
Authors: Rateb Mostafa E. , Ebel Rainer
Published: April 2011

Review: 478 refs.
ChemInform Abstract: Marine Chemical Ecology in Benthic Environments
Authors: Paul Valerie J. , Ritson‐Williams Raphael , Sharp Koty
Published: April 2011

Review: 270 refs.
ChemInform Abstract: Chemical Ecology of the Marine Plankton
Authors: Sieg R. Drew , Poulson‐Ellestad Kelsey L. , Kubanek Julia
Published: April 2011

Review: 97 refs.
ChemInform Abstract: Antifouling Marine Natural Products
Authors: Fusetani Nobuhiro
Published: April 2011

Review: 124 refs.
ChemInform Abstract: New Trends in Polymer Electrolytes
Authors: Srivastava Neelam , Tiwari Tuhina
Published: April 2011

Review: 145 refs.
ChemInform Abstract: Bioorganometallics: Future Trends in Drug Discovery, Analytical Chemistry, and Catalysis
Authors: Hillard Elizabeth A. , Jaouen Gerard
Published: April 2011

Review: 92 refs.
ChemInform Abstract: Multifunctionality in Hybrid Magnetic Materials Based on Bimetallic Oxalate Complexes
Authors: Clemente‐Leon Miguel , Coronado Eugenio , Marti‐Gastaldo Carlos , Romero Francisco M.
Published: April 2011

Review: 99 refs.
ChemInform Abstract: Determining Association Constants from Titration Experiments in Supramolecular Chemistry
Authors: Thordarson Pall
Published: April 2011

Review: 38 refs.
ChemInform Abstract: Theory, Experiment and Unusual Features of Potential Energy Surfaces of Pericyclic and Pseudopericyclic Reactions with Sequential Transition Structures
Authors: Birney David Martin
Published: April 2011

Review: 69 refs.
ChemInform Abstract: Studying Double Group Transfer Reactions by Means of Computational Methods
Authors: Fernandez Israel , Cossio Fernando P.
Published: April 2011

Review: 56 refs.
ChemInform Abstract: Experimental Approaches for NMR Studies of Side‐Chain Dynamics in High‐Molecular‐Weight Proteins
Authors: Sheppard Devon , Sprangers Remco , Tugarinov Vitali
Published: April 2011

Review: 182 refs.
ChemInform Abstract: The Chemical Composition of Biomass
Authors: Vassilev Stanislav V. , Baxter David , Andersen Lars K. , Vassileva Christina G.
Published: April 2011

Review: 95 refs.
ChemInform Abstract: High‐Resolution Microwave Spectroscopy of Chiral Molecular Contact Pairs
Authors: Liu Xunchen , Xu Yunjie
Published: April 2011

Review: 49 refs.
ChemInform Abstract: Solid‐State 13C NMR Spectroscopy — A Powerful Characterization Tool for Thermotropic Liquid Crystals
Authors: Narasimhaswamy T.
Published: April 2011

Review: 121 refs.
Asymmetric polymerizations of chiral 4‐benzyl‐2‐ethynyloxazoline with rhodium catalyst and chiroptical properties of the polymers
Authors: Onimura Kenjiro , Shintaku Keiko , Rattanatraicharoen Poompat , Yamabuki Kazuhiro , Oishi Tsutomu
Published: April 2011

Optically active 4‐alkyl‐2‐ethynyloxazoline derivatives (BnEOx) were polymerized with rhodium catalysts. The polymerization in toluene produced polymer with the highest absolute values of specific rotation ([α]D = −77.3°). The yields, molecular weights, and specific rotations of poly(BnEOx)s were influenced by polymerization conditions. The copolymerization with phenylacetylene (PA) was effective to increase the molecular weight of the copolymer. It is interesting to note that the copolymers exhibited positive specific rotations ([α]D = +4.7° to +62.5°) despite the fact that [α]Ds of BnEOx and the homopolymer are negative sign. The chiroptical properties were investigated by the chiral/achiral copolymerization of BnEOx with PA. The copolymerizations of BnEOx with PA gave copolymers containing higher order structure such as one‐handed helical conformation. Furthermore, induced Cotton effects were observed in the π–π* transition region of conjugated main chain depending a complex of these polymers with zinc triflate salt in tetrahydrofuran solution, indicating the formation of chiral supramolecular aggregates. Chirality, 2011. © 2011 Wiley Periodicals, Inc.
Experimental and theoretical studies of vacuum‐ultraviolet electronic circular dichroism of hydroxy acids in aqueous solution
Authors: Fukuyama Takayuki , Matsuo Koichi , Gekko Kunihiko
Published: April 2011

The electronic circular dichroism (ECD) spectra of three L‐hydroxy acids (L‐lactic acid, (+)‐(S)‐2‐hydroxy‐3‐methylbutyric acid, and (−)‐(S)‐2‐hydroxyisocaproic acid) were measured down to 160 nm in aqueous solution using a vacuum‐ultraviolet ECD spectrophotometer. To assign the two positive peaks around 210 and 175 nm and the one negative peak around 190 nm in the observed spectra, the ECD spectrum of L‐lactic acid was calculated using time‐dependent density functional theory (DFT) for the optimized structures by DFT and a continuum model. The observed ECD spectrum was successfully reproduced as the average spectrum for four optimized structures with seven water molecules that localized around the COO− and OH groups of L‐lactic acid. The positive peak around 210 nm and the negative peak around 185 nm in the calculated spectrum were attributable to the nπ* transition of the carboxyl group, with the latter peak also being influenced by the ππ* transition of the carboxyl group; however, the positive peak around 165 nm involved unassignable higher energy transitions. The comparison of the calculated ECD spectra for L‐lactic acid and L‐alanine revealed that the network with loose hydrogen bonding around the COO− and OH groups is responsible for the flexible conformation of hydroxy acids and complicated side‐chain dependence of ECD spectra relative to amino acids. Chirality, 2011. © 2011 Wiley Periodicals, Inc.
Mapping the Catechol Binding Site in Dopamine D1Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues
Authors: Bonner Lisa A. , Laban Uros , Chemel Benjamin R. , Juncosa Jose I. , Lill Markus A. , Watts Val J. , Nichols David E.
Published: April 2011

A novel class of isochroman dopamine analogues, originally reported by Abbott Laboratories, have >100‐fold selectivity for D1‐like over D2‐like receptors. We synthesized a parallel series of chroman compounds and showed that repositioning the oxygen atom in the heterocyclic ring decreases potency and confers D2‐like receptor selectivity to these compounds. In silico modeling supports the hypothesis that the altered pharmacology for the chroman series is due to potential intramolecular hydrogen bonding between the oxygen in the chroman ring and themeta‐hydroxy group of the catechol moiety. This interaction realigns the catechol hydroxy groups and disrupts key interactions between these ligands and critical serine residues in TM5 of the D1‐like receptors. This hypothesis was tested by the synthesis and pharmacological evaluation of a parallel series of carbocyclic compounds. Our results suggest that if the potential for intramolecular hydrogen bonding is removed, D1‐like receptor potency and selectivity are restored.
Resource allocation for multiuser cognitive OFDM networks with proportional rate constraints
Authors: Wang Shaowei , Huang Fangjiang , Yuan Mindi , Du Sidan
Published: April 2011

In this paper we study the resource allocation problem for the multiuser orthogonal frequency division multiplexing (OFDM)‐based cognitive radio (CR) systems with proportional rate constraints. The mutual interference introduced by primary user (PU) and cognitive radio user (also referred to secondary user, SU) makes the optimization problem of CR systems more complex. Moreover, the interference introduced to PUs must be kept under a given threshold. In this paper, the highest achievable rate of each OFDM subchannel is calculated by jointly considering the channel gain and interference level. First, a subchannel is assigned to the SU with the highest achievable rate. The remaining subchannels are always allocated to the SU that suffers the severest unjustness. Second, an efficient bit allocation algorithm is developed to maximize the sum capacity, which is again based on the highest achievable rate of each subchannel. Finally, an adjustment procedure is designed to maintain proportional fairness. Simulation results show that the proposed algorithm maximizes the sum capacity while keeping the proportional rate constraints satisfied. The algorithm exhibits a good tradeoff between sum capacity maximization and proportional fairness. Furthermore, the proposed algorithm has lower complexity compared with other algorithms, rendering it promising for practical applications. Copyright © 2011 John Wiley & Sons, Ltd.
Mobile device integration of a fingerprint biometric remote authentication scheme
Authors: Chen Chin‐Ling , Lee Cheng‐Chi , Hsu Chao‐Yung
Published: April 2011

Various user authentication schemes with smart cards have been proposed. Generally, researchers implicitly assume that the contents of a smart card cannot be revealed. However, this is not true. An attacker can analyze the leaked information and obtain the secret values in a smart card. To improve on this drawback, we involve a fingerprint biometric and password to enhance the security level of the remote authentication scheme Our scheme uses only hashing functions to implement a robust authentication with a low computation property. Copyright © 2011 John Wiley & Sons, Ltd.
Male urethral pap smears and peniscopy examination and polymerase chain reaction human papillomavirus correlation
Authors: Lilia Tena‐Suck Martha , Alarcón‐Herrera América , Tirado‐Sánchez Andrés , Rösl Frank , la Vega Horacio Astudillo‐de
Published: April 2011

The aims of this study were to determine HPV in a male population and its correlation with penile gross inspection and urethral pap smears. Fifty male volunteers were included in the study; all of them were sexual partners of women with evidence of HPV‐related cervical diseases. Urethral Pap smear features and polymerase chain reaction (PCR; HPV detection) of urethral samples were correlated. Statistical analyses were conducted to identify variables associated with high and low‐risk HPV types. Mean age of participants was 33.14 ± 1.52 (range, 23–50 years), and the mean age for those with high risk HPV was 32.12 ± 6.66 and 34.08 ± 6.58 for subjects with low‐risk HPV (P = 0.820). Penile gross inspection revealed 19 (38%) cases with no lesions, papules in balanoprepusial furrol/sulcus in 23 (46%) cases, papilla in 23 (46%) cases, urethral lesions in 22 (44%) cases, penile body plaques in 22 (44%) cases, melanoses in 11 (22%) cases, sebaceous cysts on scrotum in 10 (20%) cases, and molting of the glands in 28 (56%) cases. Cytopathologic analysis revealed koilocytes in 24 (48%) cases. Dyskeratosis was observed in 24 (48%) cases. A bacterial background was found in 27 (54%) cases, and inflammatory cells were found in 27 (54%) cases. Twenty‐six (52%) cases showed cytological features suggestive of Gardnerella Vaginalis. Twenty‐four (48%) cases were high‐risk HPV, and 26 (52%) were low‐risk HPV (P = 0.037) as assessed by PCR‐based detection. There was a statistically significant difference between koilocytes and bacterial background with high‐risk human papillomavirus (P = 0.001). Abnormal colposcopy examination detected lesions were sampled for cytology by Pap smears. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Diagnostic value of liquid‐based (Liqui‐PREP) preparations and interobserver reproducibility in fine needle aspiration cytology of the nodular thyroid lesions
Authors: Tetikkurt U. S. , Oz Puyan F. , Oz F. , Erdogan N. , Ceylan S. , Yakupoglu A.
Published: April 2011

The aim of this study is to define the diagnostic role of Liqui‐Prep (LP) technique for the diagnosis of thyroid lesions and to assess interobserver variabilities. In all, 98 thyroid FNA (fine needle aspiration) cytology samples from 83 patients for preoperative evaluation of thyroid nodules, prepared by the LP, were examined. The LP slides were independently evaluated by three pathologists and they were classified into the five categories according to the Bethesda system. The histopathologic diagnoses were grouped as follows: benign, follicular neoplasm, and malignant. Agreements between LP and histopathologic diagnoses were investigated using kappa values. Marginal homogenity and kappa tests were used for statistical analysis for the evaluation of the agreement between the pathologists and the interobserver variability of the thyroid aspiration cytology results. The presence of nucleoli, nuclear grooving, overlapping, intranuclear inclusion, and nuclear irregularity were recorded and scored on each case based on LP slide review. Concurrences between LP and the histologic diagnoses for the three pathologists were almost perfect (k = 0.798; k = 0.826; k = 0.880). When the observers were paired there was no significant difference from the diagnostic point of view. Interobserver agreement among the three pathologists was moderate. Initially diagnostic difficulties may occur because of the inadequate experience of the pathologists concerning the evaluation of the cytologic changes associated with this new technique. Liqui‐Prep technique is useful for the cytologic diagnosis of the thyroid nodules. The nuclear irregularity was the most essential feature for the differentiation of malignant lesions from follicular neoplasm by the LP method. Diagn. Cytopathol. 2011; © 2011 Wiley‐Liss, Inc.
Isolated leishmanial lymphadenopathy – A rare type of leishmaniasis in India: A Case Report
Authors: Sharma Mahamaya , Malhotra Ashwini
Published: April 2011

A patient presented with isolated, soft to firm, inguinal swelling since childhood clinically thought to be a benign lipomatous lesion. Fine‐needle aspiration of the swelling revealed amastigote form of Leishmania donovani in a background of reactive lymphoid hyperplasia. Excision of the swelling resulted in reversal of positive Aldehyde test. Isolated leishmanial lymphadenopathy in an immunocompetent person, is a rare manifestation of leishmaniasis in India. The possible role of transplacental transmission is discussed. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Patterns of papillary thyroid carcinoma cells analyzed in fine‐needle aspiration smears may reveal changes in tumor cell behavior
Authors: Nikonenko Alexander G. , Bozhok Yuriy M.
Published: April 2011

Fine‐needle aspiration (FNA) cytology is widely used to examine thyroid lesions. However, its diagnostic accuracy is limited by the narrow choice of cytopathologic markers indicative of invasive/metastatic powers of a tumor. The aim of this study was to identify features that may serve as such indicators. We have examined FNA smears of 50 histologically proven papillary thyroid carcinoma (PTC) cases applying computer‐assisted morphometry to assess patterns formed by PTC cells. Cytokeratine (CK) 8 immunocytochemistry was used to verify the epithelial origin of cells under study. All analyzed smears contained blood, histiocyte‐like cells and CK8‐positive follicular cells occurring both as single cells and in monolayer cell sheets. In 60% of cases we revealed cell sheets displaying two distinct cell patterns. The first one (pattern R) consisted of moderately pleomorphic, rather regularly arranged cells having an amphophilic cytoplasm. The second one (pattern I) was formed by highly pleomorphic cells with a basophilic cytoplasm. Patterns R and I were clearly different in cell size and shape as well as in nuclear size and shape. These patterns were never observed within the same cell sheet indicating that they may be formed by different subclones of tumor cells. Thus, it can be concluded that PTC frequently displays two definitely different cell patterns. We think that these patterns have a potential to serve as indicators for early events of an invasive/metastatic process. It remains to be seen whether the simultaneous occurrence of these patterns is a PTC‐specific feature. Diagn. Cytopathol. 2012;40:E55–E61. © 2011 Wiley Periodicals, Inc.
Endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) of mediastinal lymph nodes: Experience from region with high prevalence of tuberculosis
Authors: Manucha Varsha , Kaur Gagandeep , Verma Kusum
Published: April 2011

Utility of EUS‐FNA in diagnosing granulomatous lesions of mediastinum in regions with high prevalence of tuberculosis has not yet been evaluated. In the present study, utility and limitations of EUS‐FNA of mediastinal lesions from a tertiary care center with high prevalence of tuberculosis were studied. All cases where EUS‐FNA had been performed to diagnose mediastinal lymphadenopathy from January 2006 to December 2008 were retrieved from the files of cytopathology laboratory. These were reviewed by the cytopathologist.

Two hundred and eighty one EUS‐FNA aspirates from 269 patients were evaluated. Satisfactory aspirates were available in 259 cases. A cytological diagnosis of granulomatous lymphadenitis was rendered in 206 cases. Of these, tuberculosis could be established as an etiology in 76 cases and sarcoidosis in 7 cases only. In remaining 123 cases the etiology of granulomatous lymphadenitis could not be established and clinical correlation was suggested. Malignancies were diagnosed or suspected in 24 and 5 cases, respectively. The study highlights that the dilemma of tuberculosis versus sarcoidosis persists in regions with high prevalence of tuberculosis. However, EUS‐FNA is useful in diagnosing unsuspected malignancies and confirming the presence of granulomatous lymphadenitis. Diagn. Cytopathol. 2013; 41:1019–1022.© 2011 Wiley Periodicals, Inc.