bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
Authors: Bertotti Andrea , Migliardi Giorgia , Galimi Francesco , Sassi Francesco , Torti Davide , Isella Claudio , Corà Davide , Di Nicolantonio Federica , Buscarino Michela , Petti Consalvo , Ribero Dario , Russolillo Nadia , Muratore Andrea , Massucco Paolo , Pisacane Alberto , Molinaro Luca , Valtorta Emanuele , Sartore-Bianchi Andrea , Risio Mauro , Capussotti Lorenzo , Gambacorta Marcello , Siena Salvatore , Medico Enzo , Sapino Anna , Marsoni Silvia , Comoglio Paolo M. , Bardelli Alberto , Trusolino Livio
Published: April 2023

PDF file - 27K
Supplementary Figure 6 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
Authors: Bertotti Andrea , Migliardi Giorgia , Galimi Francesco , Sassi Francesco , Torti Davide , Isella Claudio , Corà Davide , Di Nicolantonio Federica , Buscarino Michela , Petti Consalvo , Ribero Dario , Russolillo Nadia , Muratore Andrea , Massucco Paolo , Pisacane Alberto , Molinaro Luca , Valtorta Emanuele , Sartore-Bianchi Andrea , Risio Mauro , Capussotti Lorenzo , Gambacorta Marcello , Siena Salvatore , Medico Enzo , Sapino Anna , Marsoni Silvia , Comoglio Paolo M. , Bardelli Alberto , Trusolino Livio
Published: April 2023

PDF file - 3.8MB
Supplementary Figures, Methods, and References from Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
Authors: Andraos Rita , Qian Zhiyan , Bonenfant Débora , Rubert Joëlle , Vangrevelinghe Eric , Scheufler Clemens , Marque Fanny , Régnier Catherine H. , De Pover Alain , Ryckelynck Hugues , Bhagwat Neha , Koppikar Priya , Goel Aviva , Wyder Lorenza , Tavares Gisele , Baffert Fabienne , Pissot-Soldermann Carole , Manley Paul W. , Gaul Christoph , Voshol Hans , Levine Ross L. , Sellers William R. , Hofmann Francesco , Radimerski Thomas
Published: April 2023

PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP production, proliferation assays, enzymatic assays with JAK2 JH1, purification of tyrosine phosporylated peptides and mass-spectrometry; Supplementary References.
Supplementary Materials, Figures 1-7, Table 1 from Metformin Accelerates the Growth of BRAFV600E-Driven Melanoma by Upregulating VEGF-A
Authors: Martin Matthew J. , Hayward Robert , Viros Amaya , Marais Richard
Published: April 2023

PDF file - 1.6MB
Supplementary Tables 1-6 from Evolutionary Pathways in BRCA1-Associated Breast Tumors
Authors: Martins Filipe C. , De Subhajyoti , Almendro Vanessa , Gönen Mithat , Park So Yeon , Blum Joanne L. , Herlihy William , Ethington Gabrielle , Schnitt Stuart J. , Tung Nadine , Garber Judy E. , Fetten Katharina , Michor Franziska , Polyak Kornelia
Published: April 2023

PDF file - 2.2MB
Supplementary Figure 8 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer
Authors: Goel Hira Lal , Chang Cheng , Pursell Bryan , Leav Irwin , Lyle Stephen , Xi Hualin Simon , Hsieh Chung-Cheng , Adisetiyo Helty , Roy-Burman Pradip , Coleman Ilsa M. , Nelson Peter S. , Vessella Robert L. , Davis Roger J. , Plymate Stephen R. , Mercurio Arthur M.
Published: April 2023

PDF file - 819K, List of primer sequences for semi-quantitative and quantitative PCR
Supplementary Figure 7 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer
Authors: Goel Hira Lal , Chang Cheng , Pursell Bryan , Leav Irwin , Lyle Stephen , Xi Hualin Simon , Hsieh Chung-Cheng , Adisetiyo Helty , Roy-Burman Pradip , Coleman Ilsa M. , Nelson Peter S. , Vessella Robert L. , Davis Roger J. , Plymate Stephen R. , Mercurio Arthur M.
Published: April 2023

PDF file - 504K, Response of xenografts of human prostate cancer specimens to IGF-1R inhibition as a function of NRP2 expression
Supplementary Figure S7 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
Authors: Jahchan Nadine S. , Dudley Joel T. , Mazur Pawel K. , Flores Natasha , Yang Dian , Palmerton Alec , Zmoos Anne-Flore , Vaka Dedeepya , Tran Kim Q.T. , Zhou Margaret , Krasinska Karolina , Riess Jonathan W. , Neal Joel W. , Khatri Purvesh , Park Kwon S. , Butte Atul J. , Sage Julien
Published: April 2023

- PDF file 965K, Analysis of microarray data for the different GPCR subunits in SCLC cells and growth inhibition of several other types of neuroendocrine tumors by the TCAs
Supplementary Figure 5 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer
Authors: Goel Hira Lal , Chang Cheng , Pursell Bryan , Leav Irwin , Lyle Stephen , Xi Hualin Simon , Hsieh Chung-Cheng , Adisetiyo Helty , Roy-Burman Pradip , Coleman Ilsa M. , Nelson Peter S. , Vessella Robert L. , Davis Roger J. , Plymate Stephen R. , Mercurio Arthur M.
Published: April 2023

PDF file - 484K, Evaluation of the contribution of FOXO1 to NRP2 expression
Supplementary Figure S6 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
Authors: Jahchan Nadine S. , Dudley Joel T. , Mazur Pawel K. , Flores Natasha , Yang Dian , Palmerton Alec , Zmoos Anne-Flore , Vaka Dedeepya , Tran Kim Q.T. , Zhou Margaret , Krasinska Karolina , Riess Jonathan W. , Neal Joel W. , Khatri Purvesh , Park Kwon S. , Butte Atul J. , Sage Julien
Published: April 2023

- PDF file 980K, Expression levels of the ligands of the GPCRs targeted by the TCAs and the enzymes required for their biosynthesis in SCLC cells
Supplementary Figure 1 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer
Authors: Goel Hira Lal , Chang Cheng , Pursell Bryan , Leav Irwin , Lyle Stephen , Xi Hualin Simon , Hsieh Chung-Cheng , Adisetiyo Helty , Roy-Burman Pradip , Coleman Ilsa M. , Nelson Peter S. , Vessella Robert L. , Davis Roger J. , Plymate Stephen R. , Mercurio Arthur M.
Published: April 2023

PDF file - 536K, Invasive behavior of cell lines used and assessment of NRP2 expression in prostate glands and cancer
Supplementary Figure S2 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
Authors: Jahchan Nadine S. , Dudley Joel T. , Mazur Pawel K. , Flores Natasha , Yang Dian , Palmerton Alec , Zmoos Anne-Flore , Vaka Dedeepya , Tran Kim Q.T. , Zhou Margaret , Krasinska Karolina , Riess Jonathan W. , Neal Joel W. , Khatri Purvesh , Park Kwon S. , Butte Atul J. , Sage Julien
Published: April 2023

Supplementary Figure S2 - PDF file 1676K, Induction of cell death and decreased proliferation following imipramine and promethazine treatment
Supplementary Table 1 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Authors: Collisson Eric A. , Trejo Christy L. , Silva Jillian M. , Gu Shenda , Korkola James E. , Heiser Laura M. , Charles Roch-Philippe , Rabinovich Brian A. , Hann Byron , Dankort David , Spellman Paul T. , Phillips Wayne A. , Gray Joe W. , McMahon Martin
Published: April 2023

XLS file - 41K, Cell lines used in this study and their genotype
Supplementary Methods, Figures 1-9 from An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway
Authors: Guo Deliang , Reinitz Felicia , Youssef Mary , Hong Cynthia , Nathanson David , Akhavan David , Kuga Daisuke , Amzajerdi Ali Nael , Soto Horacio , Zhu Shaojun , Babic Ivan , Tanaka Kazuhiro , Dang Julie , Iwanami Akio , Gini Beatrice , DeJesus Jason , Lisiero Dominique D. , Huang Tiffany T. , Prins Robert M. , Wen Patrick Y. , Robins H. Ian , Prados Michael D. , DeAngelis Lisa M. , Mellinghoff Ingo K. , Mehta Minesh P. , James C. David , Chakravarti Arnab , Cloughesy Timothy F. , Tontonoz Peter , Mischel Paul S.
Published: April 2023

PDF file - 903K
Supplementary Figure 5 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Authors: Collisson Eric A. , Trejo Christy L. , Silva Jillian M. , Gu Shenda , Korkola James E. , Heiser Laura M. , Charles Roch-Philippe , Rabinovich Brian A. , Hann Byron , Dankort David , Spellman Paul T. , Phillips Wayne A. , Gray Joe W. , McMahon Martin
Published: April 2023

PDF file - 379K, Dose response curves of human PDA cell lines treated with either MEK inhibitor GSK1120212, AKT inhibitor GSK690693, or both together
Supplementary Figure 4 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Authors: Collisson Eric A. , Trejo Christy L. , Silva Jillian M. , Gu Shenda , Korkola James E. , Heiser Laura M. , Charles Roch-Philippe , Rabinovich Brian A. , Hann Byron , Dankort David , Spellman Paul T. , Phillips Wayne A. , Gray Joe W. , McMahon Martin
Published: April 2023

PDF file - 2.1MB, MEK inhibition induces AKT activation
Supplementary Video 5 from IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
Authors: Smith Courtney , Chang Mee Young , Parker Katherine H. , Beury Daniel W. , DuHadaway James B. , Flick Hollie E. , Boulden Janette , Sutanto-Ward Erika , Soler Alejandro Peralta , Laury-Kleintop Lisa D. , Mandik-Nayak Laura , Metz Richard , Ostrand-Rosenberg Suzanne , Prendergast George C. , Muller Alexander J.
Published: April 2023

AVI file - 3MB, 360 degree views of the lungs of a Lox-KrasG12D mouse 24 weeks following Ad-cre virus infection. Tumor/vasculature is colored red (exterior)/orange (interior) with surrounding lung tissue colored translucent green
Supplementary Figure 3 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Authors: Collisson Eric A. , Trejo Christy L. , Silva Jillian M. , Gu Shenda , Korkola James E. , Heiser Laura M. , Charles Roch-Philippe , Rabinovich Brian A. , Hann Byron , Dankort David , Spellman Paul T. , Phillips Wayne A. , Gray Joe W. , McMahon Martin
Published: April 2023

PDF file - 194K, RAF and MEK co inhibition
Supplementary Video 4 from IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
Authors: Smith Courtney , Chang Mee Young , Parker Katherine H. , Beury Daniel W. , DuHadaway James B. , Flick Hollie E. , Boulden Janette , Sutanto-Ward Erika , Soler Alejandro Peralta , Laury-Kleintop Lisa D. , Mandik-Nayak Laura , Metz Richard , Ostrand-Rosenberg Suzanne , Prendergast George C. , Muller Alexander J.
Published: April 2023

AVI file - 2.2MB, 360 degree views of the lungs of an Ido1-/- KrasG12D mouse 18 weeks following Ad-cre virus infection. Tumor/vasculature is colored red (exterior)/orange (interior) with surrounding lung tissue colored translucent green
Supplementary Figure 2 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Authors: Collisson Eric A. , Trejo Christy L. , Silva Jillian M. , Gu Shenda , Korkola James E. , Heiser Laura M. , Charles Roch-Philippe , Rabinovich Brian A. , Hann Byron , Dankort David , Spellman Paul T. , Phillips Wayne A. , Gray Joe W. , McMahon Martin
Published: April 2023

PDF file - 331K, MEK inhibitor PD325901 inhibits MEK in vivo
Supplementary Video 3 from IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
Authors: Smith Courtney , Chang Mee Young , Parker Katherine H. , Beury Daniel W. , DuHadaway James B. , Flick Hollie E. , Boulden Janette , Sutanto-Ward Erika , Soler Alejandro Peralta , Laury-Kleintop Lisa D. , Mandik-Nayak Laura , Metz Richard , Ostrand-Rosenberg Suzanne , Prendergast George C. , Muller Alexander J.
Published: April 2023

AVI file - 2.5MB, 360 degree views of the lungs of a Lox-KrasG12D mouse 18 weeks following Ad-cre virus infection. Tumor/vasculature is colored red (exterior)/orange (interior) with surrounding lung tissue colored translucent green
Supplementary Table 7 from Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1
Authors: Byers Lauren Averett , Wang Jing , Nilsson Monique B. , Fujimoto Junya , Saintigny Pierre , Yordy John , Giri Uma , Peyton Michael , Fan You Hong , Diao Lixia , Masrorpour Fatemeh , Shen Li , Liu Wenbin , Duchemann Boris , Tumula Praveen , Bhardwaj Vikas , Welsh James , Weber Stephanie , Glisson Bonnie S. , Kalhor Neda , Wistuba Ignacio I. , Girard Luc , Lippman Scott M. , Mills Gordon B. , Coombes Kevin R. , Weinstein John N. , Minna John D. , Heymach John V.
Published: April 2023

PDF file, 95K, Antibodies used in reverse-phase protein microarrays
Supplementary Table 5 from Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1
Authors: Byers Lauren Averett , Wang Jing , Nilsson Monique B. , Fujimoto Junya , Saintigny Pierre , Yordy John , Giri Uma , Peyton Michael , Fan You Hong , Diao Lixia , Masrorpour Fatemeh , Shen Li , Liu Wenbin , Duchemann Boris , Tumula Praveen , Bhardwaj Vikas , Welsh James , Weber Stephanie , Glisson Bonnie S. , Kalhor Neda , Wistuba Ignacio I. , Girard Luc , Lippman Scott M. , Mills Gordon B. , Coombes Kevin R. , Weinstein John N. , Minna John D. , Heymach John V.
Published: April 2023

PDF file, 61K, mRNA transcripts significantly different between SCLC and NSCLC tumors.
Supplementary Table 1 from Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1
Authors: Byers Lauren Averett , Wang Jing , Nilsson Monique B. , Fujimoto Junya , Saintigny Pierre , Yordy John , Giri Uma , Peyton Michael , Fan You Hong , Diao Lixia , Masrorpour Fatemeh , Shen Li , Liu Wenbin , Duchemann Boris , Tumula Praveen , Bhardwaj Vikas , Welsh James , Weber Stephanie , Glisson Bonnie S. , Kalhor Neda , Wistuba Ignacio I. , Girard Luc , Lippman Scott M. , Mills Gordon B. , Coombes Kevin R. , Weinstein John N. , Minna John D. , Heymach John V.
Published: April 2023

PDF file, 54K, Small cell lung cancer cell lines.
Supplementary Figure Legends 1-10 from Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors
Authors: Jaspers Janneke E. , Kersbergen Ariena , Boon Ute , Sol Wendy , van Deemter Liesbeth , Zander Serge A. , Drost Rinske , Wientjens Ellen , Ji Jiuping , Aly Amal , Doroshow James H. , Cranston Aaron , Martin Niall M.B. , Lau Alan , O'Connor Mark J. , Ganesan Shridar , Borst Piet , Jonkers Jos , Rottenberg Sven
Published: April 2023

PDF file - 86K
Supplementary Table 2 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
Authors: O'Connell Michael P. , Marchbank Katie , Webster Marie R. , Valiga Alexander A. , Kaur Amanpreet , Vultur Adina , Li Ling , Herlyn Meenhard , Villanueva Jessie , Liu Qin , Yin Xiangfan , Widura Sandy , Nelson Janelle , Ruiz Nivia , Camilli Tura C. , Indig Fred E. , Flaherty Keith T. , Wargo Jennifer A. , Frederick Dennie T. , Cooper Zachary A. , Nair Suresh , Amaravadi Ravi K. , Schuchter Lynn M. , Karakousis Giorgos C. , Xu Wei , Xu Xiaowei , Weeraratna Ashani T.
Published: April 2023

PDF file 197K, Table of patient characteristics, and Wnt5A staining in paired samples pre and post-therapy
Supplementary Figure 2 from Noncovalent Wild-type–Sparing Inhibitors of EGFR T790M
Authors: Lee Ho-June , Schaefer Gabriele , Heffron Timothy P. , Shao Lily , Ye Xiaofen , Sideris Steve , Malek Shiva , Chan Emily , Merchant Mark , La Hank , Ubhayakar Savita , Yauch Robert L. , Pirazzoli Valentina , Politi Katerina , Settleman Jeff
Published: April 2023

PDF file - 28K, PKC412 is the most selective EGFR T790M inhibitor tested versus EGFR wild-type.
Supplementary Figures 1-3 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence
Authors: Wall Meaghan , Poortinga Gretchen , Stanley Kym L. , Lindemann Ralph K. , Bots Michael , Chan Christopher J. , Bywater Megan J. , Kinross Kathryn M. , Astle Megan V. , Waldeck Kelly , Hannan Katherine M. , Shortt Jake , Smyth Mark J. , Lowe Scott W. , Hannan Ross D. , Pearson Richard B. , Johnstone Ricky W. , McArthur Grant A.
Published: April 2023

PDF file - 165K, Morphology of tumors. SF2: Everolimus restores B-cell development. SF3: B-cell precursors in the bone marrow
Supplementary Methods, Figures 1-5 from mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
Authors: Rodrik-Outmezguine Vanessa S. , Chandarlapaty Sarat , Pagano Nen C. , Poulikakos Poulikos I. , Scaltriti Maurizio , Moskatel Elizabeth , Baselga José , Guichard Sylvie , Rosen Neal
Published: April 2023

Supplementary Methods, Figures 1-5 from mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
Supplementary Figure 4 from PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
Authors: Ibrahim Yasir H. , García-García Celina , Serra Violeta , He Lei , Torres-Lockhart Kristine , Prat Aleix , Anton Pilar , Cozar Patricia , Guzmán Marta , Grueso Judit , Rodríguez Olga , Calvo Maria Teresa , Aura Claudia , Díez Orland , Rubio Isabel T. , Pérez José , Rodón Jordi , Cortés Javier , Ellisen Leif W. , Scaltriti Maurizio , Baselga José
Published: April 2023

PDF file - 3.4MB, Concordance in ER, PR, HER2, and PTEN expression between original patient tumors and the derived tumor grafts
Supplementary Figure 2 from PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
Authors: Ibrahim Yasir H. , García-García Celina , Serra Violeta , He Lei , Torres-Lockhart Kristine , Prat Aleix , Anton Pilar , Cozar Patricia , Guzmán Marta , Grueso Judit , Rodríguez Olga , Calvo Maria Teresa , Aura Claudia , Díez Orland , Rubio Isabel T. , Pérez José , Rodón Jordi , Cortés Javier , Ellisen Leif W. , Scaltriti Maurizio , Baselga José
Published: April 2023

PDF file - 208K, PI3K blockade suppresses BRCA1/2 transcription
Supplementary Figure 7 from Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells
Authors: Ding Yu , Hubert Christopher G. , Herman Jacob , Corrin Philip , Toledo Chad M. , Skutt-Kakaria Kyobi , Vazquez Julio , Basom Ryan , Zhang Bin , Risler Jennifer K. , Pollard Steven M. , Nam Do-Hyun , Delrow Jeffery J. , Zhu Jun , Lee Jeongwu , DeLuca Jennifer , Olson James M. , Paddison Patrick J.
Published: April 2023

PDF file - 27K, Measurement of mitotic transit times BTIC-G166 cells using live microscopy for mBUB1B allelic complementation experiments (from Figure 5)
Supplementary Table 1 from Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors
Authors: Ercan Dalia , Xu Chunxiao , Yanagita Masahiko , Monast Calixte S. , Pratilas Christine A. , Montero Joan , Butaney Mohit , Shimamura Takeshi , Sholl Lynette , Ivanova Elena V. , Tadi Madhavi , Rogers Andrew , Repellin Claire , Capelletti Marzia , Maertens Ophélia , Goetz Eva M. , Letai Anthony , Garraway Levi A. , Lazzara Matthew J. , Rosen Neal , Gray Nathanael S. , Wong Kwok-Kin , Jänne Pasi A.
Published: April 2023

PDF file - 74K, Table describing clinical and molecular characteristics of NSCLC patients
Supplementary Figure 5 from Coordinate Direct Input of Both KRAS and IGF1 Receptor to Activation of PI3 kinase in KRAS-Mutant Lung Cancer
Authors: Molina-Arcas Miriam , Hancock David C. , Sheridan Clare , Kumar Madhu S. , Downward Julian
Published: April 2023

Supplementary Figure 5 - PDF file 124K, Effects of combining MEK and IGF1R inhibitors on cell viability and apoptosis in NSCLC cell lines
Supplementary Tables 1 - 3 from MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer
Authors: Mitra Anirban K. , Zillhardt Marion , Hua Youjia , Tiwari Payal , Murmann Andrea E. , Peter Marcus E. , Lengyel Ernst
Published: April 2023

PDF file - 198K, Analysis of microRNA array and gene array data.
Supplementary Figure Legend from Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer
Authors: Bose Ron , Kavuri Shyam M. , Searleman Adam C. , Shen Wei , Shen Dong , Koboldt Daniel C. , Monsey John , Goel Nicholas , Aronson Adam B. , Li Shunqiang , Ma Cynthia X. , Ding Li , Mardis Elaine R. , Ellis Matthew J.
Published: April 2023

PDF file - 22K
Supplementary Table 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Authors: Sen Malabika , Thomas Sufi M. , Kim Seungwon , Yeh Joanne I. , Ferris Robert L. , Johnson Jonas T. , Duvvuri Umamaheswar , Lee Jessica , Sahu Nivedita , Joyce Sonali , Freilino Maria L. , Shi Haibin , Li Changyou , Ly Danith , Rapireddy Srinivas , Etter Jonathan P. , Li Pui-Kai , Wang Lin , Chiosea Simion , Seethala Raja R. , Gooding William E. , Chen Xiaomin , Kaminski Naftali , Pandit Kusum , Johnson Daniel E. , Grandis Jennifer R.
Published: April 2023

PDF file - 165K, EC50 values of STAT3 decoy in cancer cell lines
Supplementary Figure Legends 1-7, Table Legends 1-2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Authors: Sen Malabika , Thomas Sufi M. , Kim Seungwon , Yeh Joanne I. , Ferris Robert L. , Johnson Jonas T. , Duvvuri Umamaheswar , Lee Jessica , Sahu Nivedita , Joyce Sonali , Freilino Maria L. , Shi Haibin , Li Changyou , Ly Danith , Rapireddy Srinivas , Etter Jonathan P. , Li Pui-Kai , Wang Lin , Chiosea Simion , Seethala Raja R. , Gooding William E. , Chen Xiaomin , Kaminski Naftali , Pandit Kusum , Johnson Daniel E. , Grandis Jennifer R.
Published: April 2023

PDF file - 70K
Supplementary Figure 7 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Authors: Sen Malabika , Thomas Sufi M. , Kim Seungwon , Yeh Joanne I. , Ferris Robert L. , Johnson Jonas T. , Duvvuri Umamaheswar , Lee Jessica , Sahu Nivedita , Joyce Sonali , Freilino Maria L. , Shi Haibin , Li Changyou , Ly Danith , Rapireddy Srinivas , Etter Jonathan P. , Li Pui-Kai , Wang Lin , Chiosea Simion , Seethala Raja R. , Gooding William E. , Chen Xiaomin , Kaminski Naftali , Pandit Kusum , Johnson Daniel E. , Grandis Jennifer R.
Published: April 2023

PDF file - 107K, Systemic delivery of cyclic STAT3 decoy does not affect total or pSTAT3 expression levels
Supplementary Figure 6 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Authors: Sen Malabika , Thomas Sufi M. , Kim Seungwon , Yeh Joanne I. , Ferris Robert L. , Johnson Jonas T. , Duvvuri Umamaheswar , Lee Jessica , Sahu Nivedita , Joyce Sonali , Freilino Maria L. , Shi Haibin , Li Changyou , Ly Danith , Rapireddy Srinivas , Etter Jonathan P. , Li Pui-Kai , Wang Lin , Chiosea Simion , Seethala Raja R. , Gooding William E. , Chen Xiaomin , Kaminski Naftali , Pandit Kusum , Johnson Daniel E. , Grandis Jennifer R.
Published: April 2023

PDF file - 122K, STAT3 decoy treatment does not inhibit cell viability or STAT3 target gene expression in A4 STAT3 null cells
Supplementary Figure 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Authors: Sen Malabika , Thomas Sufi M. , Kim Seungwon , Yeh Joanne I. , Ferris Robert L. , Johnson Jonas T. , Duvvuri Umamaheswar , Lee Jessica , Sahu Nivedita , Joyce Sonali , Freilino Maria L. , Shi Haibin , Li Changyou , Ly Danith , Rapireddy Srinivas , Etter Jonathan P. , Li Pui-Kai , Wang Lin , Chiosea Simion , Seethala Raja R. , Gooding William E. , Chen Xiaomin , Kaminski Naftali , Pandit Kusum , Johnson Daniel E. , Grandis Jennifer R.
Published: April 2023

PDF file - 2.5MB, The chemistry used to generate the modified decoys
Supplementary Table 13 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia
Authors: Geng Huimin , Brennan Sarah , Milne Thomas A. , Chen Wei-Yi , Li Yushan , Hurtz Christian , Kweon Soo-Mi , Zickl Lynette , Shojaee Seyedmehdi , Neuberg Donna , Huang Chuanxin , Biswas Debabrata , Xin Yuan , Racevskis Janis , Ketterling Rhett P. , Luger Selina M. , Lazarus Hillard , Tallman Martin S. , Rowe Jacob M. , Litzow Mark R. , Guzman Monica L. , Allis C. David , Roeder Robert G. , Müschen Markus , Paietta Elisabeth , Elemento Olivier , Melnick Ari M.
Published: April 2023

XLS file - 176K, DNA methylation and gene expression signature of MLLr ALL
Supplementary Table 10 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia
Authors: Geng Huimin , Brennan Sarah , Milne Thomas A. , Chen Wei-Yi , Li Yushan , Hurtz Christian , Kweon Soo-Mi , Zickl Lynette , Shojaee Seyedmehdi , Neuberg Donna , Huang Chuanxin , Biswas Debabrata , Xin Yuan , Racevskis Janis , Ketterling Rhett P. , Luger Selina M. , Lazarus Hillard , Tallman Martin S. , Rowe Jacob M. , Litzow Mark R. , Guzman Monica L. , Allis C. David , Roeder Robert G. , Müschen Markus , Paietta Elisabeth , Elemento Olivier , Melnick Ari M.
Published: April 2023

XLS file - 136K, DNA methylation and gene expression signature of E2A-PBX1-positive B-ALL
Supplementary Methods, Figures, Tables, and References from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer
Authors: Wang Xiao-Song , Shankar Sunita , Dhanasekaran Saravana M. , Ateeq Bushra , Sasaki Atsuo T. , Jing Xiaojun , Robinson Daniel , Cao Qi , Prensner John R. , Yocum Anastasia K. , Wang Rui , Fries Daniel F. , Han Bo , Asangani Irfan A. , Cao Xuhong , Li Yong , Omenn Gilbert S. , Pflueger Dorothee , Gopalan Anuradha , Reuter Victor E. , Kahoud Emily Rose , Cantley Lewis C. , Rubin Mark A. , Palanisamy Nallasivam , Varambally Sooryanarayana , Chinnaiyan Arul M.
Published: April 2023

Supplementary Methods, Figures, Tables, and References from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer
Supplementary Movie 8 from Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium
Authors: Iwanicki Marcin P. , Davidowitz Rachel A. , Ng Mei Rosa , Besser Achim , Muranen Taru , Merritt Melissa , Danuser Gaudenz , Ince Tan , Brugge Joan S.
Published: April 2023

File Type: .mov; File Size: 1.5 MB.
Supplementary Table 4 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
Authors: Sanda Takaomi , Tyner Jeffrey W. , Gutierrez Alejandro , Ngo Vu N. , Glover Jason , Chang Bill H. , Yost Arla , Ma Wenxue , Fleischman Angela G. , Zhou Wenjun , Yang Yandan , Kleppe Maria , Ahn Yebin , Tatarek Jessica , Kelliher Michelle A. , Neuberg Donna S. , Levine Ross L. , Moriggl Richard , Müller Mathias , Gray Nathanael S. , Jamieson Catriona H.M. , Weng Andrew P. , Staudt Louis M. , Druker Brian J. , Look A. Thomas
Published: April 2023

XLSX file - 35K, Sensitivities to TYK2 knockdown and JAK Inhibitor I treatment, and phosphorylation status of downstream signaling molecules in T-ALL cell lines and Ba/F3 clones.
Supplementary Table 3 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
Authors: Sanda Takaomi , Tyner Jeffrey W. , Gutierrez Alejandro , Ngo Vu N. , Glover Jason , Chang Bill H. , Yost Arla , Ma Wenxue , Fleischman Angela G. , Zhou Wenjun , Yang Yandan , Kleppe Maria , Ahn Yebin , Tatarek Jessica , Kelliher Michelle A. , Neuberg Donna S. , Levine Ross L. , Moriggl Richard , Müller Mathias , Gray Nathanael S. , Jamieson Catriona H.M. , Weng Andrew P. , Staudt Louis M. , Druker Brian J. , Look A. Thomas
Published: April 2023

XLSX file - 30K, Targeting sequences for shRNAs.
Supplementary Table 1 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
Authors: Sanda Takaomi , Tyner Jeffrey W. , Gutierrez Alejandro , Ngo Vu N. , Glover Jason , Chang Bill H. , Yost Arla , Ma Wenxue , Fleischman Angela G. , Zhou Wenjun , Yang Yandan , Kleppe Maria , Ahn Yebin , Tatarek Jessica , Kelliher Michelle A. , Neuberg Donna S. , Levine Ross L. , Moriggl Richard , Müller Mathias , Gray Nathanael S. , Jamieson Catriona H.M. , Weng Andrew P. , Staudt Louis M. , Druker Brian J. , Look A. Thomas
Published: April 2023

XLSX file - 36K, Cell viability profile by RAPID assay.
Supplementary Figure Legend and Methods from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
Authors: Sanda Takaomi , Tyner Jeffrey W. , Gutierrez Alejandro , Ngo Vu N. , Glover Jason , Chang Bill H. , Yost Arla , Ma Wenxue , Fleischman Angela G. , Zhou Wenjun , Yang Yandan , Kleppe Maria , Ahn Yebin , Tatarek Jessica , Kelliher Michelle A. , Neuberg Donna S. , Levine Ross L. , Moriggl Richard , Müller Mathias , Gray Nathanael S. , Jamieson Catriona H.M. , Weng Andrew P. , Staudt Louis M. , Druker Brian J. , Look A. Thomas
Published: April 2023

PDF file - 138K
Supplementary Figures 6 - 8 from Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment
Authors: Braas Daniel , Ahler Ethan , Tam Brenna , Nathanson David , Riedinger Mirielle , Benz Matthias R. , Smith Kathleen B. , Eilber Fritz C. , Witte Owen N. , Tap William D. , Wu Hong , Christofk Heather R.
Published: April 2023

PDF file - 85K, Supplemental Figure 6: Gemcitabine has a cytotoxic effect on three liposarcoma cell lines. Supplemental Figure 7: Gemcitabine is cytotoxic to liposarcoma cell lines and xenograft tumors in mice. Supplemental Figure 8: Gemcitabine decreases tumor growth in serially passaged LPS2 xenografts.
Supplementary Table 2 from Outlier Kinase Expression by RNA Sequencing as Targets for Precision Therapy
Authors: Kothari Vishal , Wei Iris , Shankar Sunita , Kalyana-Sundaram Shanker , Wang Lidong , Ma Linda W. , Vats Pankaj , Grasso Catherine S. , Robinson Dan R. , Wu Yi-Mi , Cao Xuhong , Simeone Diane M. , Chinnaiyan Arul M. , Kumar-Sinha Chandan
Published: April 2023

XLSX file - 776K, Breast sample kinome compendium by RNA-Seq.
Supplementary Figure 2 from Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling
Authors: Young Amy , Lou David , McCormick Frank
Published: April 2023

PDF file - 319K, Validation of multiple siRNAs targeting HRAS, KRAS, or NRAS
Supplementary Figure 7 from Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers
Authors: Barkovich Krister J. , Hariono Sujatmi , Garske Adam L. , Zhang Jie , Blair Jimmy A. , Fan Qi-Wen , Shokat Kevan M. , Nicolaides Theodore , Weiss William A.
Published: April 2023

PDF file - 60K
Supplementary Figure 5 from Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers
Authors: Barkovich Krister J. , Hariono Sujatmi , Garske Adam L. , Zhang Jie , Blair Jimmy A. , Fan Qi-Wen , Shokat Kevan M. , Nicolaides Theodore , Weiss William A.
Published: April 2023

PDF file - 45K
Supplementary Figure 11 from Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers
Authors: Barkovich Krister J. , Hariono Sujatmi , Garske Adam L. , Zhang Jie , Blair Jimmy A. , Fan Qi-Wen , Shokat Kevan M. , Nicolaides Theodore , Weiss William A.
Published: April 2023

PDF file - 219K
Supplementary Methods, Figures 1-9, Tables 1-3 from Genomic Complexity and AKT Dependence in Serous Ovarian Cancer
Authors: Hanrahan Aphrothiti J. , Schultz Nikolaus , Westfal Maggie L. , Sakr Rita A. , Giri Dilip D. , Scarperi Stefano , Janikariman Manickam , Olvera Narciso , Stevens Ellen V. , She Qing-Bai , Aghajanian Carol , King Tari A. , de Stanchina Elisa , Spriggs David R. , Heguy Adriana , Taylor Barry S. , Sander Chris , Rosen Neal , Levine Douglas A. , Solit David B.
Published: April 2023

PDF file - 356K
Supplementary Figure 10 from Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers
Authors: Barkovich Krister J. , Hariono Sujatmi , Garske Adam L. , Zhang Jie , Blair Jimmy A. , Fan Qi-Wen , Shokat Kevan M. , Nicolaides Theodore , Weiss William A.
Published: April 2023

PDF file - 524K
Supplementary Figure 1 from Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers
Authors: Barkovich Krister J. , Hariono Sujatmi , Garske Adam L. , Zhang Jie , Blair Jimmy A. , Fan Qi-Wen , Shokat Kevan M. , Nicolaides Theodore , Weiss William A.
Published: April 2023

PDF file - 174K
Supplementary Table 7 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Authors: Marcotte Richard , Brown Kevin R. , Suarez Fernando , Sayad Azin , Karamboulas Konstantina , Krzyzanowski Paul M. , Sircoulomb Fabrice , Medrano Mauricio , Fedyshyn Yaroslav , Koh Judice L.Y. , van Dyk Dewald , Fedyshyn Bohdana , Luhova Marianna , Brito Glauber C. , Vizeacoumar Franco J. , Vizeacoumar Frederick S. , Datti Alessandro , Kasimer Dahlia , Buzina Alla , Mero Patricia , Misquitta Christine , Normand Josee , Haider Maliha , Ketela Troy , Wrana Jeffrey L. , Rottapel Robert , Neel Benjamin G. , Moffat Jason
Published: April 2023

XLS file - 41K
Supplementary Figure Legends 1-6 from Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Authors: Juvekar Ashish , Burga Laura N. , Hu Hai , Lunsford Elaine P. , Ibrahim Yasir H. , Balmañà Judith , Rajendran Anbazhagan , Papa Antonella , Spencer Katherine , Lyssiotis Costas A. , Nardella Caterina , Pandolfi Pier Paolo , Baselga José , Scully Ralph , Asara John M. , Cantley Lewis C. , Wulf Gerburg M.
Published: April 2023

PDF file - 169K
Supplementary Figure 6 from Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Authors: Juvekar Ashish , Burga Laura N. , Hu Hai , Lunsford Elaine P. , Ibrahim Yasir H. , Balmañà Judith , Rajendran Anbazhagan , Papa Antonella , Spencer Katherine , Lyssiotis Costas A. , Nardella Caterina , Pandolfi Pier Paolo , Baselga José , Scully Ralph , Asara John M. , Cantley Lewis C. , Wulf Gerburg M.
Published: April 2023

PDF file - 159K, Erk phosphorylation after treatments with NVP-BKM120 in vivo. Tumor tissues were harvested from MMTV-CreBRCA1f/fp53+/- mice within 3 hours after the last treatment with NVP-BKM120. Tissues were fixed and processed for immunohistochemistry with anti-phospho ERK (Thr202/Tyr204) antibodies. 400 x magnification
Supplementary Table 5b from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Authors: Marcotte Richard , Brown Kevin R. , Suarez Fernando , Sayad Azin , Karamboulas Konstantina , Krzyzanowski Paul M. , Sircoulomb Fabrice , Medrano Mauricio , Fedyshyn Yaroslav , Koh Judice L.Y. , van Dyk Dewald , Fedyshyn Bohdana , Luhova Marianna , Brito Glauber C. , Vizeacoumar Franco J. , Vizeacoumar Frederick S. , Datti Alessandro , Kasimer Dahlia , Buzina Alla , Mero Patricia , Misquitta Christine , Normand Josee , Haider Maliha , Ketela Troy , Wrana Jeffrey L. , Rottapel Robert , Neel Benjamin G. , Moffat Jason
Published: April 2023

XLS file - 47K
Supplementary Figure 3 from Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Authors: Juvekar Ashish , Burga Laura N. , Hu Hai , Lunsford Elaine P. , Ibrahim Yasir H. , Balmañà Judith , Rajendran Anbazhagan , Papa Antonella , Spencer Katherine , Lyssiotis Costas A. , Nardella Caterina , Pandolfi Pier Paolo , Baselga José , Scully Ralph , Asara John M. , Cantley Lewis C. , Wulf Gerburg M.
Published: April 2023

PDF file - 137K, Effects of the combination of NVP-BKM120 and Olaparib (left pair, treated with NVP-BKM120 at 30 mg/kg/day and Olaparib at 50 mg/kg/day) and of Olaparib alone (right pair, 50 mg/kg/day). Mice were imaged before and after 3 daily treatments, the repeat scan was obtained within 3 hours after the third treatment. The mouse on the right had multiple synchronous primary tumors, labeled in the before and after images with blue, orange and yellow arrows. Percent FDG-uptake was 65% (tumor with orange arrow), 55% (tumor with blue arrow) and 64% (tumor with yellow arrow). The mouse in the image pair on the right that was treated with Olaparib carried only one macroscopically detectable tumor (red arrow). Olaparib treatments increased FDG-uptake by 75% in this tumor. Note that in the after-Olaparib-treatment image (far right) several hotspots in the upper thorax are visible which upon necroscopy were found to be tumors of less than 2 mm in diameter
Supplementary Table 4 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Authors: Marcotte Richard , Brown Kevin R. , Suarez Fernando , Sayad Azin , Karamboulas Konstantina , Krzyzanowski Paul M. , Sircoulomb Fabrice , Medrano Mauricio , Fedyshyn Yaroslav , Koh Judice L.Y. , van Dyk Dewald , Fedyshyn Bohdana , Luhova Marianna , Brito Glauber C. , Vizeacoumar Franco J. , Vizeacoumar Frederick S. , Datti Alessandro , Kasimer Dahlia , Buzina Alla , Mero Patricia , Misquitta Christine , Normand Josee , Haider Maliha , Ketela Troy , Wrana Jeffrey L. , Rottapel Robert , Neel Benjamin G. , Moffat Jason
Published: April 2023

XLS file - 32K
Supplementary Figure Legends from Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis
Authors: Eisinger-Mathason T.S. Karin , Zhang Minsi , Qiu Qiong , Skuli Nicolas , Nakazawa Michael S. , Karakasheva Tatiana , Mucaj Vera , Shay Jessica E.S. , Stangenberg Lars , Sadri Navid , Puré Ellen , Yoon Sam S. , Kirsch David G. , Simon M. Celeste
Published: April 2023

Supplementary Figure Legends - PDF file 104K, Supplementary Figure Legends
Supplementary Figure 2 from Identifying the Ubiquitin Ligase Complex That Regulates the NF1 Tumor Suppressor and Ras
Authors: Hollstein Pablo E. , Cichowski Karen
Published: April 2023

Supplementary Figure 2 - PDF file 250K, DN-Cul3 stabilizes Cul3 targets regulates neurofibromin-dependent MAPK activation
Supplementary Methods, Figures S1 - S14, Tables S1, S3 - S10 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Authors: Lin Ling , Chamberlain Lynn , Pak Magnolia L. , Nagarajan Arvindhan , Gupta Romi , Zhu Lihua J. , Wright Casey M. , Fong Kwun M. , Wajapeyee Narendra , Green Michael R.
Published: April 2023

Supplementary Information includes: Supplementary Methods providing additional information on experimental techniques and data analysis; Supplementary Figures S1-S14 providing critical control experiments and raw data analyses for experiments presented in the main manuscript; and Supplementary Tables S1-S10 summarizing data presented in the main manuscript as well as listing reagents.
Supplementary Table S6 from Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Authors: Shi Hubing , Hugo Willy , Kong Xiangju , Hong Aayoung , Koya Richard C. , Moriceau Gatien , Chodon Thinle , Guo Rongqing , Johnson Douglas B. , Dahlman Kimberly B. , Kelley Mark C. , Kefford Richard F. , Chmielowski Bartosz , Glaspy John A. , Sosman Jeffrey A. , van Baren Nicolas , Long Georgina V. , Ribas Antoni , Lo Roger S.
Published: April 2023

XLSX file 12K, DP-specific genetic variants in the PI3K-PTEN-AKT pathway and their gene IDs, conservation predictions as well as allelic frequencies in normal, baseline and DP tissues as called by distinct pipelines
Supplementary Table S4 from Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Authors: Shi Hubing , Hugo Willy , Kong Xiangju , Hong Aayoung , Koya Richard C. , Moriceau Gatien , Chodon Thinle , Guo Rongqing , Johnson Douglas B. , Dahlman Kimberly B. , Kelley Mark C. , Kefford Richard F. , Chmielowski Bartosz , Glaspy John A. , Sosman Jeffrey A. , van Baren Nicolas , Long Georgina V. , Ribas Antoni , Lo Roger S.
Published: April 2023

XLS file 56K, List of called variants re-sequenced by Sanger, their gene identities, protein sequences, and the primers used for Sanger sequencing
Supplementary Table S3 from Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Authors: Shi Hubing , Hugo Willy , Kong Xiangju , Hong Aayoung , Koya Richard C. , Moriceau Gatien , Chodon Thinle , Guo Rongqing , Johnson Douglas B. , Dahlman Kimberly B. , Kelley Mark C. , Kefford Richard F. , Chmielowski Bartosz , Glaspy John A. , Sosman Jeffrey A. , van Baren Nicolas , Long Georgina V. , Ribas Antoni , Lo Roger S.
Published: April 2023

XLSX file 16K, WES data characteristics including library construction, total reads, base coverage, capture specificity
Supplementary Table S2 from Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Authors: Shi Hubing , Hugo Willy , Kong Xiangju , Hong Aayoung , Koya Richard C. , Moriceau Gatien , Chodon Thinle , Guo Rongqing , Johnson Douglas B. , Dahlman Kimberly B. , Kelley Mark C. , Kefford Richard F. , Chmielowski Bartosz , Glaspy John A. , Sosman Jeffrey A. , van Baren Nicolas , Long Georgina V. , Ribas Antoni , Lo Roger S.
Published: April 2023

PDF file 175K, Catalogue of mechanisms and pathways analyzed and their results
Supplementary Methods, Figure Legend, Tables 1 - 2 from Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors
Authors: Castaño Zafira , Marsh Timothy , Tadipatri Ramya , Kuznetsov Hanna S. , Al-Shahrour Fatima , Paktinat Mahnaz , Greene-Colozzi April , Nilsson Björn , Richardson Andrea L. , McAllister Sandra S.
Published: April 2023

PDF file - 125K, Supplemental Table 1: PCR Oligonucleotide Primers. Supplemental Table 2: Antibodies.
Supplementary Table S1 from Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Authors: Shi Hubing , Hugo Willy , Kong Xiangju , Hong Aayoung , Koya Richard C. , Moriceau Gatien , Chodon Thinle , Guo Rongqing , Johnson Douglas B. , Dahlman Kimberly B. , Kelley Mark C. , Kefford Richard F. , Chmielowski Bartosz , Glaspy John A. , Sosman Jeffrey A. , van Baren Nicolas , Long Georgina V. , Ribas Antoni , Lo Roger S.
Published: April 2023

PDF file 89K, Clinical characteristics of patients and their responses to BRAF inhibitors
Supplementary Figure 8 from Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors
Authors: Castaño Zafira , Marsh Timothy , Tadipatri Ramya , Kuznetsov Hanna S. , Al-Shahrour Fatima , Paktinat Mahnaz , Greene-Colozzi April , Nilsson Björn , Richardson Andrea L. , McAllister Sandra S.
Published: April 2023

PDF file - 159K, Identification of Instigating Human Breast Tumor Surgical Specimens.
Supplementary Figure S2 from Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Authors: Shi Hubing , Hugo Willy , Kong Xiangju , Hong Aayoung , Koya Richard C. , Moriceau Gatien , Chodon Thinle , Guo Rongqing , Johnson Douglas B. , Dahlman Kimberly B. , Kelley Mark C. , Kefford Richard F. , Chmielowski Bartosz , Glaspy John A. , Sosman Jeffrey A. , van Baren Nicolas , Long Georgina V. , Ribas Antoni , Lo Roger S.
Published: April 2023

PDF file 8842K, Supplementary Figure S2 contains Sanger re-sequencing to estimate the specificity of WES
Supplementary Figure 6 from Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors
Authors: Castaño Zafira , Marsh Timothy , Tadipatri Ramya , Kuznetsov Hanna S. , Al-Shahrour Fatima , Paktinat Mahnaz , Greene-Colozzi April , Nilsson Björn , Richardson Andrea L. , McAllister Sandra S.
Published: April 2023

PDF file - 90K, EGF and IGF-1 Together Modulate Viability and Expression Profile of Responder Cells.
Supplementary Figure 5 from Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors
Authors: Castaño Zafira , Marsh Timothy , Tadipatri Ramya , Kuznetsov Hanna S. , Al-Shahrour Fatima , Paktinat Mahnaz , Greene-Colozzi April , Nilsson Björn , Richardson Andrea L. , McAllister Sandra S.
Published: April 2023

PDF file - 51K, EGF and IGF-1 Together Modulate Tumorogenicity of Responder Cells in vitro.
Supplementary Figure 3 from Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors
Authors: Castaño Zafira , Marsh Timothy , Tadipatri Ramya , Kuznetsov Hanna S. , Al-Shahrour Fatima , Paktinat Mahnaz , Greene-Colozzi April , Nilsson Björn , Richardson Andrea L. , McAllister Sandra S.
Published: April 2023

PDF file - 174K, Activation of EGF and IGF1 Receptors.
Supplementary Table 1 from Prospective Blinded Study of BRAFV600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders
Authors: Hyman David M. , Diamond Eli L. , Vibat Cecile Rose T. , Hassaine Latifa , Poole Jason C. , Patel Minal , Holley Veronica R. , Cabrilo Goran , Lu Timothy T. , Arcila Maria E. , Chung Young Rock , Rampal Raajit , Lacouture Mario E. , Rosen Neal , Meric-Bernstam Funda , Baselga José , Kurzrock Razelle , Erlander Mark G. , Janku Filip , Abdel-Wahab Omar
Published: April 2023

Supplemental Table 1: Concordance of initial urinary cell-free DNA (cfDNA) assessment of BRAFV600E mutation with tissue biopsy BRAFV600E result.
Supplementary Figure 2 from Prospective Blinded Study of BRAFV600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders
Authors: Hyman David M. , Diamond Eli L. , Vibat Cecile Rose T. , Hassaine Latifa , Poole Jason C. , Patel Minal , Holley Veronica R. , Cabrilo Goran , Lu Timothy T. , Arcila Maria E. , Chung Young Rock , Rampal Raajit , Lacouture Mario E. , Rosen Neal , Meric-Bernstam Funda , Baselga José , Kurzrock Razelle , Erlander Mark G. , Janku Filip , Abdel-Wahab Omar
Published: April 2023

Supplemental Figure 2: Radiographic, histologic, and molecular evaluation of KRASG12S mutant patient with Erdheim-Chester Disease (ECD).
Supplementary Materials from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress
Authors: Feng Yu-xiong , Sokol Ethan S. , Del Vecchio Catherine A. , Sanduja Sandhya , Claessen Jasper H.L. , Proia Theresa A. , Jin Dexter X. , Reinhardt Ferenc , Ploegh Hidde L. , Wang Qiu , Gupta Piyush B.
Published: April 2023

PDF file 99K, Supplementary figure and table legends
Supplementary Figure 2 from GSK-3α Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1–TAB Stabilization and Regulation of Noncanonical NF-κB
Authors: Bang Deepali , Wilson Willie , Ryan Meagan , Yeh Jen Jen , Baldwin Albert S.
Published: April 2023

PDF file - 181K, Left: Kras regulates TAK1 levels. HKRAS cells were transiently transfected with non-targeting or Kras siRNA for 72 hours. TAK1 was immunoprecitated from whole cell extracts and immunoblotted for specified antibodies. Right: TAK1 inhibition induces apoptosis. MiaPaCa-2 cells were treated with the TAK1 inhibitor, 5Z-7-oxozaenol at indicated concentrations for 24 hours. Whole cells extracts were immunoblotted with specified antibodies.
Supplementary Methods, Figure Legends, Table Legends from Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma
Authors: Ryan Russell J.H. , Drier Yotam , Whitton Holly , Cotton M. Joel , Kaur Jasleen , Issner Robbyn , Gillespie Shawn , Epstein Charles B. , Nardi Valentina , Sohani Aliyah R. , Hochberg Ephraim P. , Bernstein Bradley E.
Published: April 2023

Supplementary Methods, Figure Legends, Table Legends
Supplementary Table 2 from Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution
Authors: Dewhurst Sally M. , McGranahan Nicholas , Burrell Rebecca A. , Rowan Andrew J. , Grönroos Eva , Endesfelder David , Joshi Tejal , Mouradov Dmitri , Gibbs Peter , Ward Robyn L. , Hawkins Nicholas J. , Szallasi Zoltan , Sieber Oliver M. , Swanton Charles
Published: April 2023

XLS file 33K, Supplementary Table 2: Univariate and Multivariate survival analysis for TCGA and validation cohort