bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of the fracture strength of single unit metal ceramic and monolithic zirconium restorations in the molar region: A systematic review and meta-analysis
Authors: İŞİSAĞ Özer , PEKTAŞ Nur
Published: April 2023

Background: Despite the increasing popularity of monolithic zirconia restorations (MZ), metal ceramic restorations (MC) are still considered the gold standard in the posterior region. The aim of this systematic review and meta-analysis was to compare the fracture strengths of single unit MC and MZ in the molar region.
Methods: This review was structured based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA 2020). Literature search was conducted in PubMed and Web of Science databases until November 18, 2022. In vitro studies that evaluated the fracture strength of MC and MZ were included. Statistical analyzes were performed with CMA (Comprehensive Meta-Analysis) program, with a significance level of 0.05.
Results:Five of 753 studies were selected. Fracture strengths of MZ and MC did not show a statistically significant difference both tooth (95% CI:-1.589: 2.118, p=0.779, z= 0.280) and implant (95% CI: -2.215: 2.191, p=0.992 z= -0.010) supported restorations. However in tooth supported restorations a significant difference was found in the subgroup analysis considering different abutment materials (P<0.001) and aging treatments (P<0.001). Additionally in implant supported restorations a significant difference was found in subgroup analysis considering different cements (p=0.001) and load speeds (p=0.001).
Conclusion:Within the limitations this present study, fracture strengths of MZ and MC did not show a significant difference in implant or tooth supported single unit restorations at posterior region.
Clinical relevance: MZ may be an alternative to MC in posterior single restorations. Present results should be interpreted with caution, as included studies were in vitro.
Detection of Cardiovascular Disease Using Gut Microbiota Data
Authors: Duyar Can , Senica Simone Oliver , Kalkan Habil
Published: April 2023

Gut microbiota are defined as the microbial population of the intestines. They include various types of bacteria which can influence and predict the existence or onset of some specific diseases. Therefore, it is a common practice in medicine to analyze the gut microbiota for diagnostic purposes by analyzing certain measurable biochemical features associated with the disease under investigation. However, the evaluation of all the data collected from the gut microbiota is a labor-intensive process. Machine learning algorithms may be a helpful tool to identify the hidden patterns in gut microbiota for the detection of disease and other classification problems. In this study, we propose a deep neural model based on 1D-CNN to detect cardiovascular disease using bacterial taxonomy and OTU (Operational Taxonomic Unit) table data. The developed method is compared to classical machine learning algorithms, regression, boosting algorithm and a deep model, TabNet, developed for tabular data and obtained outperforming classification results. The proposed method is robust and well adapted to taxonomy data in tabular form. It can be easily adapted to detect other diseases by using taxonomy data.
Structural features of T-DNA that induce transcriptional gene silencing during agroinfiltration
Authors: Iida Emi , Kuriyama Kazunori , Tabara Midori , Takeda Atsushi , Suzuki Nobuhiro , Moriyama Hiromitsu , Fukuhara Toshiyuki
Published: April 2023

Agrobacterium tumefaciens (Rhizobium radiobacter) is used for the transient expression of foreign genes by the agroinfiltration method, but the introduction of foreign genes often induces transcriptional and/or post-transcriptional gene silencing (TGS and/or PTGS). In this study, we characterized the structural features of T-DNA that induce TGS during agroinfiltration. When A. tumefacienscells harboring an empty T-DNA plasmid containing the cauliflower mosaic virus (CaMV) 35S promoter were infiltrated into the leaves of Nicotiana benthamiana line 16c with a GFP gene over-expressed under the control of the same promoter, no small interfering RNAs (siRNAs) were derived from the GFP sequence. However, siRNAs derived from the CaMV 35S promoter were detected, indicating that TGS against the GFP gene was induced. When the GFP gene was inserted into the T-DNA plasmid, PTGS against the GFP gene was induced whereas TGS against the CaMV 35S promoter was suppressed. In other words, depending on the combination of promoter and coding sequences on T-DNA and the host nuclear genome, either or both TGS and/or PTGS could be induced by agroinfiltration. We also showed the importance of terminator sequences in T-DNA for gene silencing and the possible involvement of three siRNA-producing Dicers in the induction of TGS. These results are valuable for controlling gene expression by agroinfiltration.
Two point mutations in CYP4CE1 promoter contributed to the differential regulation of CYP4CE1 expression by FoxO between susceptible and nitenpyram resistant Nilaparvata lugens
Authors: Zhang Huihui , Lin Xumin , Yang Baojun , Zhang Lingchun , Liu Zewen
Published: April 2023

Four P450s were reported to be important for imidacloprid resistance in Nilaparvata lugens, a major insect pest on rice, which was confirmed in this study in an imidacloprid resistant strain (ImiR). Here we found that only two (CYP4CE1 and CYP6ER1) from these four P450 genes were over-expressed in a nitenpyram resistant strain (NitR) when compared to a susceptible strain SUS. CYP4CE1 RNAi reduced nitenpyram and imidacloprid resistance in NitR and ImiR strains, with a more reduction in nitenpyram resistance. The transcription factor FoxO mediated nitenpyram resistance in NitR and ImiR strains, but it was not differentially expressed among strains. The potential reason for the differential regulation of FoxO on CYP4CE1 expression was mainly from sequence differences in CYP4CE1promoter between susceptible and resistant insects. In six FoxO response elements predicted in CYP4CE1 promoter, the single-nucleotide polymorphisms were frequently detected in over 50% of NitR and ImiR individuals. The luciferase reporter assays showed that two mutations, -650T/G and -2205T/A in two response elements at the position of -648 bp and -2200 bp, mainly contributed to the enhanced regulation on CYP4CE1 expression by FoxO in resistant insects. The frequency was over 69% for both -650T/G and -2205T/A detected in NitR and ImiR individuals, but less than 20% in SUS insects. In conclusion,CYP4CE1 over-expression importantly contributed to nitenpyram resistance in N. lugens, and two mutations in CYP4CE1 promoter of resistant insects led to an enhanced regulation on CYP4CE1 expression by FoxO.
Drug-resistance, treatment outcome and their predictors in pulmonary tuberculosis at Yirgalem General Hospital Multidrug-Resistance Tuberculosis treatment initiation center, Sidama Region, South Ethiopia: a Retrospective cohort study
Authors: Kebede Assefa Hamato , Idris Hassen Mamo
Published: April 2023

Background: Tuberculosis (TB) is one of the oldest diseases known and the spread of drug-resistant TB poses significant challenges in TB control and eradication program globally, and also the distribution varies geographically worldwide and within the countries. Lack of universal access to rapid diagnostic test, poor infection control and mismanagement of TB at different level increases the spread of DR-TB. The final treatment outcome of patient implicates the level of program implementation in TB control. The current study aimed to assess the proportions of drug-resistance, treatment outcome and their predictors among pulmonary MDR/RR-TB treated patients.
Methods: A six year, 2014 to 2019 retrospective cohort review was conducted for all confirmed pulmonary DR-TB cases admitted at Yirgalem General Hospital treatment initiation center. The records of 228 total MDR/RR-TB cases 32 cases, such as referral cases outside the study area, extra pulmonary tuberculosis and incomplete data were excluded.
Results: Overall, 196 MDR/RR-TB patients included in the study. 184(93.9%) cases were labeled as rifampicin (RIF) mono-drug resistance and 8 (4.1%) cases had resistance to both Isoniazid and Rifampicin (MDR-TB) while 4 (2%) patients were diagnosed for additional resistance for second line drugs (SLDS) at the enrollment. Overall, 131(68.9 %) patients had the recorded treatment success in which 86 (43.9%) patients declared cured while 27(13.8%) declared completed treatment. The trend of successful treatment outcomes fluctuates over the years. The proportion declines from 81.9% in 2014 to 52.4% in 2016. Unsuccessful treatment in cohort was 65(31.1%) of MDR-TB. Of which 18(9.2%) were died during the treatment course while 27(13.8%) and 6(3.1%) were LTFU and treatment failure respectively. multivariate analysis revealed, being above age greater than 26 (AOR: 1.45; 95%CI: 1.044, 2.006), co-morbid disease other than HIV (AOR: 1.71; 95%CI: 0.937, 12.618), baseline positive sputum smear (AOR: 0.54; 95%CI: 0.375, 0.789) were significantly associated with unfavorable treatment outcomes with P-value<0.05.
Conclusion: 2% additional resistance for SLDs is alarming. Treatment success rate was lower than targeted set by World health organization. Factors affecting poor treatment outcome in MDR-TB management needs to be addressed through targeted interventions. Strengthened TB control strategies should in place to reduce further transmission of drug resistance.
Multifractal analysis of local polynomial entropies for recurrence time
Authors: Si Hongying , Peng Dongmei , Liu Lei
Published: April 2023

In this paper, we introduce the local polynomial entropies and mul-tifractal spectra associated with Poincaré recurrences. By using characteristics of a dynamical system we establish an exact formula on multifractal spectrum of local polynomial entropies for recurrence time.
Mathematics Subject Classification (2010). 54H20, 37B20, 37B40.
Transferable deep learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing
Authors: Yu Xiang , Wu You , Shao Wenna , Yan Mengxiao , Wang Yuqin , Li Xiaofei , Gregory Brian , Yang Jun , Wang Hongxia
Published: April 2023

RNA modifications play crucial roles in various biological processes. Current methods for epitranscriptome profiling using nanopore direct RNA sequencing (DRS) are unable to simultaneously identify multiple types of modifications. Here, we developed TandemMod, a transferable deep learning framework capable of detecting multiple types of RNA modifications in single DRS data. To train high-performance TandemMod models, we generated in vitro epitranscriptome (IVET) datasets from plant cDNA libraries, containing thousands of transcripts labeled with various types of RNA modifications. TandemMod trained on IVET datasets displayed high accuracy of prediction, outperforming existing tools. We applied TandemMod to identify RNA modifications in human cell lines and rice grown in different environments, demonstrating its applicability across species and conditions. In summary, we provide an IVET resource with ground-truth labels that can serve as benchmark datasets for DRS-based machine learning methods, and a deep learning framework, TandemMod, for identifying diverse RNA modifications using single DRS data.
Using the ceRNA network to predict the new circRNA-miRNA-mRNA on pathogenesis of systemic lupus erythematosus
Authors: He Juanjuan , Jianwen Liu , Chenmin Wu , Yunfeng Dai , Zhihan Chen , Yanfang Wu
Published: April 2023

Background
Circular RNAs (circRNAs) are a new class of endogenous non-coding RNA molecules that do not have a 5'-terminal cap and a 3'-terminal poly (A) tail and form a closed ring structure with covalent bonds. They act as competitive endogenous RNAs (ceRNAs) or microRNAs (miRNAs), which in turn influence and regulate the expression of target genes and mRNA.
It has been established that these circRNA-associated ceRNAs play significant roles in autoimmune illnesses, although it is still unknown how the circRNA-miRNA-mRNA network in systemic lupus erythematosus works.
Methods
In this investigation, the self-test data and the differential expression of circRNA in the GEO database were retrieved, as well as the circRNA in the bone marrow of SLE patients and healthy volunteers. Using the limma package of R program, the differential expression of mRNA and miRNA in the GEO database was discovered. Then miRNA-mRNA pairs and circRNA-miRNA pairs were established using miRcode, miRDB, miRTarbase, and TargetScan. Additionally, circRNA-miRNA-mRNA ceRNA network was built using Cytoscape, and Hub genes were screened using a protein-protein interaction network.
Results
We created 66 up-regulated circRNAs, 164 down-regulated circRNAs, 167 up-regulated mRNAs, 1916 down-regulated mRNAs, 15 up-regulated miRNAs, and 71 down-regulated miRNAs in accordance with the predetermined hypothesis. SLE development is significantly influenced by pathways in malignancies, according to functional and enrichment studies. Significant biomarkers include SIRT and ESR1. Our predictions included hsa miR 22 3p and HSA circ 0000345, two possible miRNAs and circRNAs that may have a major impact on SLE.
Conclusions
Our study discovered novel circRNA miRNAs and mRNAs through ceRNA network analysis that could be employed as potential biomarkers for SLE and as treatment targets for SLE.
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
Authors: Choi In Young , Ling Jonathan P. , Zhang Jian , Helmenstine Eric , Walter Wencke , Bergman Riley E. , Philippe Céline , Manley James L. , Rouault-Pierre Kevin , Li Bing , Wiseman Daniel H. , Ouseph Madhu , Bernard Elsa , Li Xiao , Haferlach Torsten , Fazal Salman , Jain Tania , Gocke Christopher D. , DeZern Amy E. , Dalton W. Brian
Published: April 2023

Among the most common genetic alterations in the myelodysplastic syndromes (MDS) are mutations in the spliceosome gene SF3B1. Such mutations induce specific RNA missplicing events, directly promote ring sideroblast (RS) formation, generally associate with more favorable prognosis, and serve as a predictive biomarker of response to luspatercept. However, not all SF3B1 mutations are the same, and here we report that the E592K variant of SF3B1 associates with high-risk disease features in MDS, including a lack of RS, increased myeloblasts, a distinct co-mutation pattern, and decreased survival. Moreover, in contrast to canonical SF3B1 mutations, E592K induces a unique RNA missplicing pattern, retains an interaction with the splicing factor SUGP1, and preserves normal RNA splicing of the sideroblastic anemia genes TMEM14C and ABCB7. These data expand our knowledge of the functional diversity of spliceosome mutations, and they suggest that patients with E592K should be approached differently from low-risk, luspatercept-responsive MDS patients with ring sideroblasts and canonical SF3B1 mutations.
Oral Health-Related Quality of Life (OHQoL) in implant-supported rehabilitations: a double-blind longitudinal prospective single-center observational cohort study
Authors: Manfredini Mattia , Pellegrini Matteo , Rigoni Marta , Beretta Mario , Maiorana Carlo , Poli Pier Paolo
Published: April 2023

Objectives. To evaluate Oral Health-Related Quality of Life (OHRQoL) perceived by the patient before and after implant-prosthetic rehabilitation, to determine the physical and psychological impact that dental implants and related prosthetic rehabilitations could have in partial or edentulous patients. Finally, it was evaluated if demographic and clinical variables could influence the patient's perceived OHRQoL.
Materials and Methods. A double-blind longitudinal prospective single-center observational cohort study was conducted with patients requiring implant-prosthetic rehabilitation to evaluate OHRQoL before (T0), during (T1), and after treatment (T2) with implant-prosthetic rehabilitations. The three scores obtained at T0, T1, and T2, respectively, were compared with the variables patient's sex, age, implants placed in the aesthetic zone versus nonaesthetic zone, number of implants used in the rehabilitation, site of rehabilitation, type of definitive prosthetic rehabilitation, and type of recipient's bone.
Results. A total of 100 patients rehabilitated with 427 implants were enrolled. Statistically significant data emerged regarding the total OHRQoL score, its 7 domains, and VAS score in the 3 times considered and in relation to gender, age, aesthetics, implants number, dental arch, type of prosthesis, and type of surgery.
Conclusions. Implant-prosthetic rehabilitations significantly improve OHRQoL and aesthetics in edentulous or partially edentulous patients. The change in OHRQoL is accompanied by a marked improvement in the patient's aesthetic perception of the new smile similar in all intervals of the study.
Clinical Relevance. OHRQoL could provide the basis for any dental health care program and should be considered an important element in the overall oral health program.
Fast convergence to an approximate solution by message-passing for complex optimizations
Authors: Hayashi Yukio
Published: April 2023

Message-passing (MP) is a powerful tool for finding an approximate solution in optimization. We generalize it in product-sum form, and numerically show the fast convergence. From the linearity of MP in a logarithmic space, it is derived that an equilibrium solution exists in a neighborhood of random initial values. These results will give one of the reason why the convergence is very fast in collective computation based on a common mathematical background.
WITHDRAWN: Cognitive Behavior Therapy for Academic Burnout, Procrastination, Self-Handicapping Behavior, and Test Anxiety among Adolescents: A Randomized Control Trial
Authors: Abbas Qasir , Khurshid Khizra , Rauf Umara , Anwar Nida , Aljhani Sumayah , Ramzan Zoobia , Shahzadi Mafia
Published: April 2023

Objective Emotional instability during adolescence could make them susceptible to developing mental problems, and these problems could enhance in severity when left unresolved. Other life stressors like job competition, peer pressure, and parental unrealistic expectations could further deteriorate their mental health. Therefore, the present study is designed to investigate the impact of cognitive behavioral therapy (CBT) on adolescents to manage procrastination, burnout, self-handicapping behavior, and test anxiety to enhance academic motivation and achievement.Materials and Methods A total of 200 students were enrolled for eligibility assessment, and 129 participants met the eligibility criteria. Participants were divided into two groups, the experimental group, and the waitlist control group. All the students completed their demographics form and screening tool, the eligible participants were given assessment measures at pre-post-assessment stages (8 weeks intervals). We used different assessment measures to assess the outcome i.e. General Procrastination Scale (GPS), Maslach Burnout Inventory-Student Survey (MBI-SS), Self-handicapping Scale (SHS), Test Anxiety Inventory (TAI), and Living up to Parental Expectation Scale (LPES). Repeated measures ANOVA was used to analyze the results.Results The current RCT findings suggest that CBT substantially reduced emotional and behavioral problems and helped the students manage parental unrealistic expectations in the experimental group compared to the waitlist control condition. Further, CBT significantly reduced the degree of procrastination {F (1, 63) = 25.01, p < .000, η2 = .29} academic burnout {F (1, 63) = 11.08, p < .000, η2 = .16}, test anxiety {F(1, 63) = 88.17, p < .000, η2 = .59}, and self-handicapping {F (3, 56) = 10.17, p < .000, η2 = .16} among adolescents. Overall, CBT significantly helped the students to manage parental unrealistic expectations through providing relationship skills and training {F (3,56) = 546.46, p < .001, η2 = .89)}.Condition: It is concluded that CBT is an effective and evidence-based treatment intervention to address emotional disturbance caused by procrastination, burnout, test anxiety, and self-handicapping behavior among adolescents. Furthermore, it is concluded that CBT is also an effective intervention that helped students to manage peer pressure and parental unrealistic expectations.
Transcriptome analysis of Indian freshwater pearl mussel Lamellidens marginalis to unravel the genes associated with biomineralization
Authors: SUMAN SONAL , Kumar Pavan , Saurabh Shailesh , Katneni Vinay Kumar , Prabhudas Sudheesh K. , Gireesh-Babu P. , Das Rekha , Chaudhari Aparna
Published: April 2023

Background:The freshwater pearl mussel Lamellidens marginalis is found throughout India and is culturing to produce freshwater pearls. Understanding the process of pearl biomineralization provides insight into the genes responsible for the secretion of the complex nacre. However, information on the transcriptome of L. marginalis pearl sac, mantle tissue and gonads are lacking.
Methods and Results: The present study generated the transcriptome resources for L. marginalis and identified genes involved in the biomineralization process in the species. The Illumina paired-end sequencing generated 11.13 million raw reads, and the reads were assembled into 133,246 contigs and 26,373 unigenes. 21,033 out of 26,373 unigenes showed homology with previously reported molluscan proteins. Genes of several proteins associated with biomineralization, namely, pif, perlucin, calreticulin, calmodulin, chitin synthase, chitin dehydrogenase, carbonic anhydrase, tyrosinase, shell matrix protein, chitinase 3, chitinase domain-containing protein 1, chitinase-like protein PB1E7.04c, and putative chitinase-1 were identified in the study.
Conclusion: This study's findings will help identify differentially expressed genes that govern the characteristics of the pearl and identify the type-I markers in the genes.
Does corruption hinder the effect of financial development on economic complexity? Evidence from MENA countries
Authors: Valentine Soumtang Bime , Motande Mondjeli Mwa Ndjokou Itchoko , Cassandra Koumis Ngagni Agathe
Published: April 2023

The objective of this article is to assess the effect of corruption in the relationship between financial development and economic complexity in Middle Eastern and North African countries from 1995 to 2020. Using the two-stage least squares method, the results reveal significant heterogeneous effects of financial development on economic complexity as a function of corruption. Specifically, the results show that corruption worsens the effect of financial access, depth, and efficiency on economic complexity over the period. In contrast, it improves the effect of financial stability on economic complexity in the region. The results appear to be robust to additional factors, another measure of economic complexity, and change in estimation technique. This result calls on policy makers to tighten controls on corruption to allow financial development to significantly enhance economic complexity.
JEL Codes: D63, K42, G20.
Gymnosperms (Pinophyta) in the Komarov Historical Collection of the Herbarium of the Herzen State Pedagogical University of Russia (HERZ)
Authors: Трофимова А.С. , Ганжур А.В. , Евдокимов А.С.
Published: April 2023

Статья содержит сведения о гербарных образцах голосеменных растений гербарной коллекции Российского государственного педагогического университета им. А.И. Герцена (HERZ). Рассмотренные материалы принадлежат к исторической части Гербария и в большинстве своем датированы концом XIX - началом XX в. Приведена информация о местах сбора имеющихся в коллекции гербарных образцов (в большинстве своем территорий современной России и Украины, некоторые образцы - из зарубежных стран - Швейцарии, Республики Корея, Японии), систематическом положении образцов (большинство представителей относятся к классу Pinopsida), а также об ученых-коллекторах, проводивших сбор и определение растений. В результате исследования обнаружено шесть гербарных образцов голосеменных растений с пометкой«dupla», собранных в ходе экспедиций Переселенческого управления. Дано краткое описание мероприятий по инвентаризации и систематизации имеющихся образцов голосеменных растений. Приведена сравнительная информация о состоянии аналогичных гербарных коллекций других высших учебных заведений Российской Федерации.

This article contains information about herbarium specimens of gymnosperms from the herbarium collection of the Herzen State Pedagogical University of Russia (HERZ). The considered materials belong to the historical part of the herbarium and are mostly dated to the end of the 19th - beginning of the 20th century. The article provides information about the collection sites for herbarium specimens available in the collection (mostly - with the territory of modern Russia and Ukraine; however, some specimens were brought from foreign countries: Switzerland, the Republic of Korea, Japan). Information is provided on the systematic position of the specimens (most representatives belong to the class Pinopsida), as well as on the scientists-collectors who collected and identified the plants. As a result of the study, 6 herbarium specimens of gymnosperms marked "dupla" were found, collected during the expeditions of the Resettlement Administration. In addition to research, a brief description of the measures for the inventory and systematization of the available samples of gymnosperms is given. The article also provides comparative information on the state of similar herbarium collections of other higher educational institutions of the Russian Federation.
Plastification and wood pressing method
Authors: Леонович А.А.
Published: April 2023

Древесину осины пропитывали водой, водными растворами карбамида и карбамида с добавкой фосфорной кислоты. Термомеханическим методом исследовали деформируемость древесины, установили основные температурные переходы. В условиях горячего прессования вода выступает не столько как литический агент, но, главным образом, как пластификатор. Карбамид снижает температуру расстекловывания на 70 С, начиная с превращений, связанных с выделением аммиака (132 С). Кислота взаимодействует с карбамидом и создаёт слабокислую среду, способствуя прочности прессованной древесины. Прессование изделий проводили при 160…180 С в две стадии со сдувкой свободной воды и последующей термообработкой при 150…180 С. Запатентован способ изготовления прессованной модифицированной древесины преимущественно паркета плотностью 600-620 кг/м3, прочностью при изгибе 120-150 МПа без использования пресс-форм.

Aspen wood was impregnated with water, aqueous solutions of urea and urea with the addition of phosphoric acid. The thermomechanical method was used to study the deformability of wood, and to establish the main temperature transitions. Under hot pressing conditions, water acts not so much as a lytic agent, but mainly as a plasticizer. Carbamide reduces the devitrification temperature by 70 C, starting with transformations associated with the release of ammonia (132 C). The acid interacts with the carbamide and creates a slightly acidic environment, contributing to the strength of the pressed wood. Products were pressed at 160...180 C in two stages with blowing off free water and subsequent heat treatment at 150...180 C. A method of manufacturing pressed modified wood, predominantly parquet, with adensity of 600-620 kg/m3 and a bending strength of 120-150 MPa without the use of molds has been patented.
The Effect of Big Data on the Development of the Insurance Industry
Authors: Belhadi Abdelkader , Abdellah Noureddine , Nezai Azzeddine
Published: April 2023

Big data is at the heart of the insurance industry through the uses it provides, where the year 2022 is considered the beginning of the “digital revolution” when humans were able to store more digital information in technological tools than ever before. Research results have shown the impact relationship between big data and various industries, including the insurance industry. Big data has improved all aspects of the insurance process, from pricing and underwriting to claims management and customer service to ultimately more effective risk management. Based on practical and theoretical practices in this framework, the question arises whether big data has brought about development in the insurance industry. Therefore, the purpose of this study was to gain a better understanding of the impact of big data on all aspects of the insurance industry. The research findings showed that the quantity and quality of data collected and used by insurance companies directly impact the services produced and developed. Big data enables insurers to identify patterns, trends and behaviors, allowing them to develop customized products and services. Also, by collecting and utilizing quality big data, insurance companies can provide more efficient and effective services, improving customer satisfaction and increasing profitability. Although big data is a lucrative opportunity for the insurance industry, it is also a threat as companies that need the means to access big data, technologies and skills will see their competitiveness drop significantly in the future. On the other hand, intermediary platforms, particularly GAFTA (Google, Apple, Facebook, Twitter, Amazon) that control the entire data value chain, can seek a large percentage of profits by providing the value chain to insurers, or the purchase of these platforms for vulnerable insurance companies, allowing them to dominate the insurance market.
The Effect of Organisational Citizenship Behavior on Cultural Diversity: A Case Study of Ophthalmological Hospital Friendship Algeria-Cuba
Authors: Zohra Djalab , Naas Said Ali , Karima Kasmi , Al-hamdany Saba Noori , aldeen Essa Eshag Emad
Published: April 2023

The increasing mobility of people around the world has led to an increasingly culturally diverse workforce, and there may be negative effects on certain cultural groups to achieve an organisational competitive advantage. In relation to this idea, this study shows the influence of both a shared vision and loyalty, teamwork, and nationality, gender, satisfaction, justice, and conflict tolerance on organisational citizenship behavior in light of cultural diversity. Testing whether these factors are related to the determination of organisational citizenship behavior through the binary response technique of multiple logistic regression, a random sample was selected from the general community of the Algerian-Cuban Friendship Hospital of Ophthalmology, and the number of its members was estimated to be 213 by answering a set of questions about the most influential factors in determining organisational citizenship behavior in the light of cultural diversity, the findings revealed a positive and meaningful relationship between shared vision, loyalty, teamwork, and nationality and organisational citizenship behavior In light of cultural diversity, these individuals often adapt to the new culture by changing their behaviors, values, and attitudes as well. Besides, there is no relationship between gender, satisfaction, justice, conflict tolerance and organisational citizenship behavior in light of cultural diversity. The current study suggests that the hospital management should formulate its values according to the employee’s cultural citizenship values, and this should be done with the different dimensions of the employee’s cultural citizenship values to reduce any conflict that arises due to differences in the value system, through training the employees continuously learn how to modify their behaviors depending on the cultural situations They face and strengthen organisational unity and cohesion. Organisational citizenship behaviors such as loyalty, shared vision, teamwork, job satisfaction, organisational justice, and tolerance of conflict can be linked to several competencies organisations use to select, train, and evaluate individuals In light of cultural diversity.
A data science-based marketing decision support system for brand management
Authors: Chornous Galyna , Fareniuk Yana , Rolandas Giedraitis Vincentas , Ulvidienė Erstida , Kharlamova Ganna
Published: April 2023

To improve the marketing activity and brand management and justify the most effective marketing decisions, organizations should implement different information technologies, mathematical methods and models into the marketing decision support system (MDSS). The goal of this paper is to form an architecture of an MDSS, the model base of which is developed on Data Science tools, in particular regression analysis and machine learning methods. The proposed MDSS is a multi-agent information system comprising nine intellectual agents (market environment monitoring, data processing, marketing mix modeling, price policy support, portfolio management, strategic analysis, forecasting, customer segmentation, and customer classification). The functionality of these agents is realized through Data Science, which allows for the optimization of marketing activities (e.g., an effective brand management strategy and its elements (portfolio strategy, price policy, and media strategy) or solving the problems of attracting new and retaining current customers with the maximal return on marketing investments). The MDSS analyzes the marketing environment, media activity, and business indicators by constructing different models and forecasting various combinations of marketing factors to select the best one. The joint work of MDSS agents provides decision-makers with interactive reports. The research findings offer a scientific basis for making effective marketing decisions based on data, and the proposed MDSS can become part of an intelligent system for planning marketing activities.
Modelling volatility effects between stock, oil, gold and forex markets: Evidence from India
Authors: Ingalhalli Varsha , Kolamker Prachi
Published: April 2023

Although several studies on the integration of diverse stock markets have been conducted in the financial literature, most of them have focused on the integration and volatility spillovers across established stock markets. The present study explores the dynamics of integration and volatility spillover across gold, oil, forex, and stock markets during four significant events in India: the pre-changed government regime, the post-changed government regime, the post-Brexit referendum date, and the COVID era. Daily data from 2010 to 2022 is divided into four categories using the Chow test. This is done to examine if these events’ financial turmoil affects market interconnectivity. The unit root test determines data stationarity. The ARCH LM test examines series volatility clustering, and the BEKK GARCH test examines market volatility spillover. Results indicate that gold cannot be considered a hedge or safe haven. Secondly, market interconnectedness increased during the crisis period. Third, domestic political and geopolitical conditions globally do not increase the scale of spillover amongst financial assets, though they impact the spillover’s magnitude. The results of this study have several important implications for portfolio diversification and risk management.
The topological soliton decay in a linear defect of the domain structure of twisted nematic
Authors:   IMCP UFRC RAS, Ufa, Russia, Delev V.A.
Published: April 2023

In this paper, the topological soliton decay in an oscillating linear defect of electroconvective structure (Williams domains) arising in π/2 twisted nematic liquid crystal are studied. In contrast to planarly oriented nematics, hydrodynamic flows in the domains of a twisted nematic have a helical character. Since, in addition to the tangential velocity component, there is also axial component, the direction of which is opposite in neighboring domains. This feature leads to the formation of stable localized extended objects — linear defects oriented normal to Williams domains. With increasing applied voltage, “zig-zag” oscillations occurs in linear defects. The boundaries between the “zig” and “zag“ states are classical dislocations. It has been found, that the dislocation, moving along the core of the defect, breaks up into an antidislocation and two dislocations. Unlike case of planarly oriented nematics, dislocations are not isolated from each other by unperturbed rolls but remain “bound” by hydrodynamic flows within the core of a linear defect. It is assumed that the splitting of the dislocation occurs as a result of the local instability of the orientational twist mode of the director n due to its strong coupling with the hydrodynamic velocity. In the framework of the sine–Gordon equation, in the presence of a dissipative term and spatial perturbations, the mechanism of a topological soliton (kink) decay into antisoliton and two solitons is considered.
Two-Dimensional numerical parametric modeling of the capillary microgripper cooling system with unsteady fluid flow
Authors:   Mavlyutov Institute of Mechanics UFRC RAS, Ufa, Russia, Nasibullayev I.Sh.
Published: April 2023

The paper presents a parametric analysis of a 2D model of a fluid cooling system for the hot side of a Peltier element of a capillary microgripper. An unsteady flow of coolant in the cooling chamber is considered. The cooling efficiency is studied for three chamber geometries with different radiator locations: monolithic, located on the Peltier element; with one or three ribs. Mathematical models are built: fluid flow through the microgripper chamber; heating the radiator with the hot side of the Peltier element; heat transfer from the radiator to fluid and the removal of the heated fluid from the chamber. The simulation is carried out in the FreeFem++ program until the average change in the temperature of the radiator over the period of fluid oscillations reaches saturation (microgripper operating mode). Using the method of orthogonal central compositional planning, analytical dependences of response functions (maximum temperature on the radiator, amplitude of temperature change on the radiator, and time to establish the operating mode) on model factors (average coolant velocity, heat transfer coefficient, frequency and amplitude of fluid velocity oscillations) are obtained. For each considered geometry and response function, leading and insignificant factors are determined. A parametric analysis of the influence of the physical parameters of the system on the operation of the cooling system was carried out. The simulation results show that the geometry that provides a high degree of cooling and a faster exit to the operating mode (radiator with three fins) has a large amplitude of temperature fluctuations on the radiator and can be used in technical devices that are less sensitive to temperature fluctuations on the radiator. The single fin radiator geometry provides the least radiator temperature fluctuation and can be used to cool capillary microgripper.
Using an ant algorithm to find a strategy for the behavior of a group of mobile robots on a work field with obstacles
Authors:   Mavlyutov Institute of Mechanics of UFRC RAS, Ufa, Russia, Darintsev O.V. , Migranov A.B.
Published: April 2023

A more complex solution to the problem of the distribution of tasks in a group of mobile robots, in the presence of obstacles in the workspace, is considered. The work is a continuation of a cycle of research in which the basic algorithm for solving the tasks was one of the types of ant algorithm — the multicolonial ant system method in combination with the trajectory planning algorithm implemented using the principle of dynamic programming. The task statement, the workspace model, the goals of the robots functioning and the parameters characterizing their work have been adjusted. The choice of free parameters of the ant algorithm for performing multi-criteria optimization and tuning of the solution is carried out: the number of iterations, the number of intercolonial groups of ants, the weight of the concentration of the pheromone of arcs, the weight of the heuristic attractiveness of arcs and the pheromone evaporation coefficient. The results of computational experiments conducted in the presence of static (known in advance) and dynamic (other robots) obstacles in the workspace are presented. The proposed algorithm was tested using the example of a group consisting of three robots performing 10 tasks. As shown in the results of computational experiments, robot trajectories are built on a subset of free cells of the workspace and do not intersect cells with obstacles. At the same time, the configuration of the work field affects not only the actual routes of robots, but also the redistribution of tasks between them, and the number of robots involved. Additionally, a series of computational experiments with different combinations of values of free parameters was carried out to determine the optimal ratios and implement a more efficient ant algorithm. Optimization was carried out by a single adjustment method, which allowed us to find the required values of free parameters. It is shown that the adjustment of the parameters made it possible to reduce the relative error in the synthesis of the optimal route of movement of a group of robots by 3–6 %.
Investigation of the spectral characteristics of a thermoviscous fluid flow in an annular channel
Authors:   Mavlyutov Institute of Mechanics, UFRC RAS, Ufa, Russia, Nizamova A.D. , Kireev V.N. , Urmancheev S.F. ,   Bashkir Sate University, Ufa, Russia
Published: April 2023

The flow of a thermoviscous model fluid in an annular channel with a given temperature field is considered. The problem of the stability of the flow of a thermoviscous fluid is solved on the basis of the generalized equation by the spectral method of expansion in Chebyshev polynomials of the first kind. The effect of taking into account the exponential dependence of the fluid viscosity on temperature and channel geometry on the spectral characteristics of the equation of hydrodynamic stability of an incompressible fluid flow in a flat channel for various wall temperatures is studied. Spectral patterns of eigenvalues of the generalized equation are constructed. The spectral characteristics determine the structure of the eigenfunctions and the critical parameters of the flow of a thermoviscous fluid. In this case, the eigenfunctions demonstrate the behavior of transverse velocity perturbations, their possible growth or decay with time. It is shown that the structure of the spectra largely depends both on the properties of the liquid, determined by the index of the functional dependence of viscosity, and on the geometry of the channel. It has been established that for small values of the thermoviscosity parameter, the spectrum is comparable to the spectrum for an isothermal fluid flow in a flat channel, however, as it increases, the number of eigenvalues and their density increase, that is, there are more points at which the problem has nonzero amplitudes of transverse velocity perturbations. The stability of a thermoviscous fluid flow depends on the presence of an eigenvalue with a positive imaginary part among the entire set of found eigenvalues for fixed parameters of the Reynolds number and wave number. It is shown that, at fixed values of the Reynolds number and wave number, the flow can become unstable with an increase in the thermoviscosity parameter.
Large Right Ventricular Hemangioma Presented as Acute Pulmonary
Embolism at Two Weeks Post-COVID19 Vaccination: A Case Report
Authors: Hassan Essam , Arafat Amr A. , Alahmadi Saeed , Roomi Asadullah , Adam Adam I
Published: April 2023

Background:

Right ventricular hemangioma is very rare. Corona Virus disease (COVID-19) and vaccination were documented to cause diverse thromboembolic phenomena.

Case presentation:

We report a large right ventricular hemangioma presented as acute pulmonary embolism two weeks after COVID-19 vaccination associated with acute kidney injury and significantly elevated Interleukin-6 (IL-6). There was no thrombocytopenia; therefore, the diagnosis of vaccine-induced immune thrombotic thrombocytopenia (VIIT) was deemed unlikely. The patient underwent emergency cardiac surgery. The mass was excised through a right atriotomy, and tricuspid annuloplasty was done. IL-6 normalized after six days with resolution of acute kidney injury.

Conclusions:

Pulmonary embolism is a rare presentation of the right ventricular hemangioma, and COVID-19 vaccination could play a role in this presentation. Cardiac hemangioma could be associated with high IL-6 that resolves with excision.
Synthesis of 1,4-Benzodiazepines by Palladium-Catalyzed C-N Coupling
Authors: Bhardwaj Pranshu , Kaur Navjeet
Published: April 2023

1,4-benzodiazepines play a valuable role in organic and medicinal chemistry. In
this review article, we have mainly discussed the synthesis of various 1,4-benzodiazepines in
the presence of a palladium catalyst. Different reactions, such as intramolecular N-arylation,
reductive elimination, oxidative addition, intramolecular alkylation, C-H activation, aryl-aryl
bond formation, etc., are included. For these types of syntheses, an easy and efficient catalytic
domino process has been reported, including the intermolecular or intramolecular reactions. In
this review article, we have also discussed catalyst regeneration and some ligand-free Pdcatalyzed
reactions.
Interaction of Human Gut Microflora with Commonly Consumed Herbs and Spices: A Review
Authors: Irshad Aksa , Rasane Prasad , Gurumayum Sushma , Singh Jyoti , Kaur Sawinder , Patel Avinash Singh , Kumar Ashwani , Kaur Jaspreet , Gunjal Mahendra , Sharma Kanu
Published: April 2023

Herbs and spices are used since time memorable to transfuse color and add flavors to
food. Their antibacterial properties also help preserve raw and cooked foods. Various diets composed
of herbs and spices, as consistent with various researches, have been shown to influence life
within the human digestive tract. This modulation forms the basis of various health effects that the
herbs and spices and the microflora have on the human health. The intestinal microbiota is engaged
in a critical function of promoting health, composed of favourable microbes (Lactobacillus
and Bifidobacterium) and potentially harmful microorganisms (Salmonella thyphimurium and
Escherichia coli). Spices and herbs make double oddities, i.e., inhibiting the proliferation of hazardous
microbes while promoting favorable ones. The paper reviews the relevant manuscripts
published in the past 20 years to understand the microbial modulation dynamics of herbs and
spices. PubMed, Mendeley, SciELO, Scopus, Science Direct, and other peer-reviewed databases
were accessed for the review. Microbial modulation is achieved by means of herbs and spices owing
to the reduction of oxidative stress caused by reactive oxygen radicals, such as OHˉ, singlet
O2, hydrogen peroxide, and superoxide radical, which leads to a threat to the intestinal microbiota.
Spices and herbs have essential oils that serve as prebiotics, reducing the demand to impart artificial
antioxidants, thus avoiding the associated health risks. Thus, the present review explores the
mechanisms and underlying functions of herbs and spices in the human gut biome.