bluuebunny/crossref_metadata_2025 huggingface dataset:
OS PROFESSORES DE ARTES E O ENSINO DA MUSICALIDADE NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Authors: Morantt Anna Alice , Gumbowsky Argos
Published: September 2021

Este estudo é resultante de uma pesquisa que aborda o ensino da musicalização nos anos iniciais do ensino fundamental das redes públicas municipal e estadual de Canoinhas, Santa Catarina, no ano letivo de 2020. O objetivo foi investigar as práticas pedagógicas dos professores de artes que atuam na rede escolar do município, bem como compreender as dificuldades que os docentes enfrentam na adoção do ensino musical como facilitador da aprendizagem dos alunos. A importância dessa pesquisa se constitui pelo diagnóstico dos problemas enfrentados nas escolas da rede municipal e estadual do município de Canoinhas com relação à introdução da musicalização em sala de aula. A metodologia adotada engloba a pesquisa exploratória, descritiva, bibliográfica, documental, de campo e quali-quantitativa. A população se constitui por 20 professores de Artes atuantes nos Anos Iniciais de Ensino Fundamental das escolas municipais e estaduais de Canoinhas. Como instrumento de pesquisa, utilizou-se um questionário composto por questões abertas e fechadas por meio da ferramenta online google forms. Foi possível constatar que os professores se sentem despreparados para o ensino da musicalidade, isso porque suas formações são em Artes Visuais (o que não contempla a formação musical);  o espaço físico não é adequado; a carga horária muito baixa; há a insuficiência de material e instrumentos; há a falta de oferta de cursos de capacitação aos docentes. Não obstante, é possível compreender que é preciso que se invista em formações pedagógicas aos professores com vistas a promover a melhoria do ensino musical, bem como o desenvolvimento da fruição dos alunos com relação a esse componente curricular obrigatório.
EM ESTADO-POÉTICO: INSURGÊNCIAS REFLEXIVAS SOBRE O PESQUISAR EM EDUCAÇÃO
Authors: Almeida Bruno Felix da Costa
Published: September 2021

O Ensaio apresenta algumas reflexões emergidas junto a Arte de Ser e de Estar músico-docente-pesquisador em estrita correlação às ações de pesquisar e refletir em um processo de doutoramento em educação. Tal insurgência foi provocada a partir do estudo dos textos “Carta a um jovem investigador em educação” (NÓVOA, 2015) e “A desmonumentalização do conhecimento escrito e arquivístico” (SANTOS, 2019), os quais constituem a trama-problematizadora, a fim expor o que se pensa sobre a ação de pesquisar, bem como os modos de apresentação dos fatos históricos, considerando versões da história. Contudo, discute-se às inquietudes de quem o escreve diante da ação de pesquisar em educação.
40Nós
Authors: Jesus Mariana
Published: September 2021

O projeto fotográfico 40Nós da artista visual e fotógrafa Mariana Jesus é um convite ao espectador para olhar dentro de um íntimo cotidiano. A série fotográfica retrata fragmentos dos dias pandêmicos da artista e sua companheira em um pequeno apartamento.
EDITORIAL
Authors: Wolffenbüttel Cristina Rolim
Published: September 2021

Breve resumo dos Artigos, Ensaios e Resenha da Tevista nº 46
Experiments on compression ignition engine powered by nano-fuels
Authors: Cieśliński Janusz T. , Krzyżak Jan , Kropiwnicki Jacek , Kneba Zbigniew
Published: September 2021

The use of nanoparticles in fuels provides new opportunities for modification of fuel properties, which may affect the operational parameters of engines, in particular the efficiency and fuel consumption. The paper presents comparison of compression ignition engine performance fuelled with neat diesel and nano-diesel. Alumina (Al2O3) was used as nanoparticles. Surface-active substances, including Span 80 surfactant, as well as water admixture were used to improve the stability of the produced fuel. Measurements of the thermal conductivity and dynamic viscosity of the produced mixtures were conducted. In this study was used naturally aspirated, water cooled, four-stroke diesel engine. Addition of Al2O3 nanoparticles result in 4% reduced fuel consumption, addition of TiO2 nanoparticles result in 10% reduced fuel consumption with respect to neat diesel fuel.
Forte São João e fortaleza de Santo Amaro da Barra Grande: guardiões da nossa identidade cultural
Authors:   Universidade Federal de Uberlândia, Nakamuta Adriana Sanajoti
Published: September 2021

Esta pesquisa é decorrente das reflexões geradas durante a graduação em Artes Plásticas na Faculdade de Artes, Filosofia e Ciências Sociais da Universidade Federal de Uberlândia e do projeto de pesquisa desenvolvido em 2003 e 2004 junto ao NUPAV (Núcleo de Pesquisa em Artes Visuais) com o apoio do PIBIC (Programa Institucional de Bolsas de Iniciação Científica – CNPq) sob a orientação da Dra. Yacy Ara Froner, que teve como objetivo o levantamento das construções fortificadas no litoral paulista brasileiro bem como uma síntese histórica e tipológica atual dos monumentos encontrados e registrados por meio de visitas locais.
As artes plásticas em Belo Horizonte, de 1918-1944: Aníbal Mattos e seu tempo
Authors:   Universidade Federal de Minas Gerais, Pousa Fabrize Santos
Published: September 2021

O interesse em estudar a arte produzida no início do século XX, aliado ao desejo de conhecer mais sobre a produção artística em Belo Horizonte levou-me a elaborar este estudo.
A unidade dos projetos estético e ideológico e a potencialidade do monumento no espaço urbano: o caso do monumento às Bandeiras e do monumento Duque de Caxias
Authors:   Universidade de São Paulo, Ribeiro Ana Carolina Fróes
Published: September 2021

No começo do século XX, as artes plásticas, no Brasil, pautavam-se na busca por uma identidade nacional e por uma modernidade já existente na Europa. Vivia-se, no país, a dubiedade de estar, de um lado voltado para o futuro e tendo a Europa a ser espelhada; e, de outro, voltado para busca por algo capaz de defini-lo e identificá-lo, mirando o passado e o tradicional.
A recepção estética dos monumentos culturais missioneiros e da arte barroca guarani no sítio de São Miguel, Rio Grande do Sul Autores João Batista Neto
Authors:   Universidade de São Paulo, Batista Neto João
Published: September 2021

Essa comunicação trata da nossa investigação no doutorado sobre a Recepção Estética dos monumentos culturais missioneiros junto aos visitantes das ruínas das Reduções Jesuíticas dos Guaranis. O objeto de análise é o sítio de São Miguel das Missões, no Rio Grande do Sul, que envolve o Museu das Missões e foi tombado como Patrimônio Cultural da Humanidade.
O retrato de Suzanne Bloch: o período azul de Pablo Picasso da obra do MASP
Authors:   Universidade Estadual de Campinas, Piacenza Luciana Bicalho
Published: September 2021

A obra "O Retrato de Suzanne Bloch" (Paris, 1904. Óleo sobre tela, 65 x 54 cm Museu de Arte de São Paulo Assis Chateaubriand, São Paulo) data do ano em que o artista Pablo Picasso transfere-se para Paris. Neste quadro, observamos a predominância da cor azul, a importância do desenho e a exposição do gesto do artista, marcado pelas pinceladas sobre o suporte.
O tocador pelo pincel: imagens da música popular na obra de Cândido Portinari
Authors:   Universidade Federal do Rio Grande do Sul, Téo Marcelo
Published: September 2021

Durante uma breve experiência sobre a obra de Cândido Portinari, acabei por me deparar com uma série de quadros que referenciavam manifestações musicais populares.
A "teoria do não-objeto”, a teoria dos “specific objects” e a emergência de novos meios artísticos no Brasil e nos Estados Unidos
Authors:   Universidade de São Paulo, Solfa Marilia
Published: September 2021

Essa pesquisa tem como objetivo aprofundar a compreensão da arte que se desenvolve nos dias atuais no Brasil e nos EUA através de um estudo comparativo da teoria e da produção artística das décadas de 50 e 60 desses países: o Neoconcretismo teorizado por Ferreira Gullar em 1959 no texto “Teoria do Não-objeto” e a Minimal Art teorizada por Donald Judd em 1965 no texto “Specific Objects”.
O aluno agregado – ou a presença de alguém que é, sem ser, na Escola Indígena Xucuru Kariri Warkanã de Aruanã, Caldas, MG
Authors: Silva Beatriz Sales da , Mantoan Maria Teresa Egler
Published: September 2021

O presente artigo tem o propósito de trazer à luz uma prática pedagógica da Escola Estadual Indígena Xucuru Kariri, do município de Caldas, MG. No intuito de entender a presença do aluno dito agregado nas turmas, vamos conhecer o que os diferentes atores da cena escolar pensam sobre o mesmo. Penetrar nos sentidos de cada uma das narrações (mônadas) em que o tema do estudo se desenrola é uma forma de reconhecer e de avaliar o que representa esse aluno para o processo educacional em uma perspectiva de escola hospitaleira.
Entre representación y representantes
Authors: Rey González Juan Carlos
Published: September 2021

Na Venezuela, depois da chegada ao poder da Revolução Bolivariana (1998), foi elaborado um novo texto constitucional (1999) em que, por primeira vez, foram reconhecidos os povos indígenas como sujeitos com direitos específicos. Este artigo revisará as principais ações do Estado em matéria indígena durante a primeira década da Revolução Bolivariana (1998-2008) com o fim de discutir o modo em que elas configuraram a representação oficial do indígena, bem como a forma em que se definiram as políticas orientadas à participação política desses grupos. A partir desta revisão, será possível apreciar que o Estado venezuelano criou um aparato institucional para que a tomada de decisões com respeito às populações indígenas não estivesse exclusivamente em suas mãos. Apesar de que esta estrutura própria supusesse uma participação cada vez maior, a partir de 2007 esta tendência se reverteu, dando lugar a um enfoque vertical orientado pela conformação do socialismo do século XXI. Assim, a participação dos povos indígenas venezuelanos na atividade do Estado foi condicionada pela evolução do projeto político revolucionário.
Performance de sonhos
Authors: Cimbaluk Lucas
Published: September 2021

Mais de vinte anos após a publicação original em inglês, de 1995, temos o privilégio de ter uma tradução em português do premiado livro “Performance de Sonhos: discursos de imortalidade Xavante” da antropóloga americana Laura R. Graham. Trata-se de uma excepcional etnografia, referência fundamental aos estudos sobre cosmologia Xavante, à etnologia indígena das Terras Baixas, de grupos Jê, em especial de estudos sobre os sons, os sonhos, performances e da análise de discursos. O livro traz análises inovadoras e instigantes que continuam em grande parte bastante atuais e que podem dialogar com trabalhos contemporâneos da área.
Círculos de coca e fumaça
Authors: Pedroso Diego Rosa
Published: September 2021

“Círculos de coca e fumaça”, publicação da tese de doutorado de Danilo Ramos, resultado de seus anos de pesquisa etnográfica no alto rio Negro, noroeste da Amazônia brasileira, constitui contribuição de grande importância para a literatura antropológica. O livro é uma etnografia das práticas do povo indígena Hupd’äh relativas à coca, com particular atenção a certa forma relacional constante da sociabilidade desse povo: as rodas de coca. Dada a riqueza e densidade da descrição etnográfica desenvolvida por Danilo Ramos, uma resenha que tente tratar de modo igual o conjunto dos capítulos está fadada ao fracasso. Assim, darei mais atenção ao contexto da pesquisa e ao lugar dos Hupd’äh na configuração social regional, os quais são apresentados logo na introdução e no primeiro capítulo. Passarei brevemente pelos capítulos subsequentes, a título de convite à leitura, arrematando com uma apreciação final do livro como um todo.
Phygital advergaming квести з доданою реальністю — ефективна технологія промоції бренда «NIKE»
Authors: Щегельська Юлія Павлівна
Published: September 2021

У цій статті досліджено досвід використання компанією «Nike» phygital advergaming AR-квестів як маркетингового та комунікаційного інструмента, за допомогою якого конверсія продажів лімітованих партій кросівок бренда за лічені хвилини сягає 100 %.
Виявлено, що оскільки сучасні споживачі швидко призвичаюються до нових форм, носіїв і методів реклами, всіляко ігнорують і уникають її, зокрема, встановлюючи програмне забезпечення для блокування рекламних повідомлень, компанії, що широко використовують phygital advergaming AR-квести, так само динамічно відкривають для себе нові можливості для промоції брендів і підтримання зв’язків із споживачами.
Доведено, що phygital advergaming AR-квести змінили традиційні маркетингові, брендінгові й комунікаційні моделі взаємодії між компаніями та споживачами їх продукції, оскільки перетворили процес покупки на гру, прихильників брендів на мисливців за речами, звичайний товар на статусний.
Досвід компанії «Nike», яка у 2017–2019 рр. трансформувала вулиці і парки окремих міст у Бразилії, Великобританії, Китаї, США, Японії та ін. країнах на свої AR pop up stores, свідчить, що використання phygital advergaming AR-квестів як промоційного засобу не тільки створює значний ажіотаж серед фанатів бренда, а й дозволяє легко привернути увагу нових цільових груп, а також уможливлює заміну прямої реклами позитивним WOM та органічним SMM й сприяє появі законодавців трендів у фанатській спільноті та амбасадорів бренда. В цілому, phygital advergaming AR-квести «Nike» створюють позитивний емоційний досвід взаємодії споживачів із брендом, що забезпечує його високу впізнаваність та підвищує лояльність до ТМ, а це, свою чергою, позитивно впливає на стимулювання збуту продукції.
У статті також наведено авторські визначення понять «phygital advergaming AR-квест» та «AR pop up shop/store».
Первинна комунікація з авторами в наукових журналах, індексованих Web of Science
Authors: Тріщук Ольга , Касянчук Валерія
Published: September 2021

Досліджено первинну комунікацію авторів з науковими журналами. Підкреслено важливість швидкого та правильного добору журналів для опублікування статті, що також пов’язано з проблемою існування «хижацьких» видань, які зосереджені на отриманні фінансової вигоди від публікацій і не забезпечують поширення наукової інформації. На основі наукових розвідок та рекомендацій видавців обґрунтовано важливість описів журналів для взаємодії з авторами і прийняття ними рішення про подальшу співпрацю. На прикладі видань комунікаційної тематики, індексованих Web of Science, установлено, що якісні видання використовують ті чи інші рекламні стратегії в цих текстах для залучення ширшого кола авторів й читачів. В описах журналів не лише вказують основну видавничу інформацію про видання, законність основ його випуску, а й роз’яснюють для аудиторії видавничі й наукові підходи, якими послуговується редакція. Встановлено низку способів впливу на автора. Опис читацької аудиторії зазвичай подають за допомогою предмета наукового зацікавлення, наукового статусу читачів, сфери діяльності, територіальної ознаки, досвіду. Пояснення мети роботи передбачає відображення впливу видання на наукову діяльність у своїй сфері. Підвищують авторитет видання і також відображають його активний внесок у наукову сферу такі способи, як підкреслення новизни й актуальності досліджень, підходів і предметної галузі видання, підтвердження високих професійних компетентностей редакції та рецензентів, вказування на зв’язок з фаховими професійними асоціаціями, науковими товариствами, закладами вищої освіти. Наявність цих аргументів може слугувати додатковим маркером для відокремлення якісних наукових журналів від «хижацьких».
Investigation of computational intelligence methods in forecasting problems at stock exchanges
Authors: Zaychenko Yuriy , Hamidov Galib , Gasanov Aydin
Published: September 2021

In this paper, the forecasting problem of share prices at the New York Stock Exchange (NYSE) was considered and investigated. For its solution the alternative methods of computational intelligence were suggested and investigated: LSTM networks, GRU, simple recurrent neural networks (RNN) and Group Method of Data Handling (GMDH). The experimental investigations of intelligent methods for the problem of CISCO share prices were carried out and the efficiency of forecasting methods was estimated and compared. It was established that method GMDH had the best forecasting accuracy compared to other methods in the problem of share prices forecasting.
Methods for researching the sustainability of production processes when implementing a cyber-physical system
Authors: Kudriavtceva Arina
Published: September 2021

The article presents an analysis of the methods and criteria for assessing sustainability and the development of stabilization systems, proposed in the theory of automatic control, and studies of approaches to ensuring sustainability, proposed and applied in the practice of controlling production processes. It is proposed to develop models when introducing a cyber-physical system of a production enterprise, combining the ideas of stabilization systems developed in the theory of automatic control, and methods of the theory and practice of managing production processes, while controlling the sustainability based on the laws and methods of systems theory and system analysis.
Modeling of a temperature field for extruder body
Authors: Trofymchuk Olexandr , Zelensky Kiril , Nastenko Ievgen
Published: September 2021

The paper considers the process of induction heating of the extruder body, the temperature of which determines the degree of heating of the polymer mixture in the zone of loading the dry mixture. A mathematical model of this process is formulated taking into account radiant heat transfer in the gap between the inductor and the case. An iterative numerical-analytical method is proposed for solving the corresponding nonlinear boundary value problem of housing heating, at the first iteration of which a linear boundary value problem is solved (without taking into account radiant heat transfer). At the subsequent stages, a nonlinear boundary value problem is solved. The iterative method is based on the application of integral transformations of the linear part of the problem, followed by an iterative scheme for finding a nonlinear problem. This scheme is based on the algorithms for the equivalent simplification of the expressions obtained by solving the problem. The results of mathematical modeling of the corresponding algorithms are presented.
Probiotic fermented dairy products – food or medication?
Authors:   Academician Yu.E.Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russian Federation, Khavkin A.I. , Kovtun T.A. ,   JSC «PROGRESS», Moscow, Russian Federation, Makarkin D.V. ,   JSC «PROGRESS», Moscow, Russian Federation, Fedotova O.B. ,   All-Russian Dairy Research Institute, Moscow, Russian Federation
Published: September 2021

One of the main strategies for preventing chronic diseases is a balanced diet from early childhood, with the inclusion of functional ingredients: dietary fiber, vitamins and vitamin-like compounds, minerals, polyunsaturated fatty acids, prebiotics and probiotics. A combined enrichment of fermented dairy products with prebiotics and probiotics contributes to the summation of their positive effective influence. Adding prebiotics and probiotics to the diet leads to the change in the intestinal microbiota composition towards a more balanced structure, thereby increasing the intestinal barrier function and the formation of optimal immune interactions. The most commonly used in human nutrition is a combination of bifidobacteria or lactobacilli with fructo-oligosaccharides in synbiotic products. It is important that the microorganisms are safe, stable in storage and able to survive in the gastrointestinal tract. The use of probiotic fermented dairy products has a positive impact on child health: it has anti-infectious and immunomodulatory effects, helps to normalize the gastrointestinal motility. These statements are confirmed by controlled studies in which children aged 8 to 18 months, recovering from acute respiratory disease, for which antibiotic therapy was prescribed, included in the diet drinking yoghurts enriched with Bifidobacterium lactis BB12 and inulin for 3 months. The inclusion of yoghurts in the children’s diet helped to normalize the intestinal microbiota composition after antibiotic therapy, as well as to strengthen the immune system by stimulating the synthesis of protective factors – secretory immunoglobulin A and lysozyme. Key words: fermented dairy products, child nutrition, probiotics, prebiotics, synbiotics, inulin, microbiota, functional foods, immune system, Bifidobacterium lactis BB12
Enteral nutrition for pediatric Crohn’s disease: significance and basic principles
Authors:   National Medical Research Center for Children’s Health, Moscow, Russian Federation, T.E.Borovik T.E.Borovik ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, A.S.Potapov A.S.Potapov ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, E.A.Roslavtseva E.A.Roslavtseva ,   National Medical Research Center for Children’s Health, Moscow, Russian Federation, A.I.Khavkin A.I.Khavkin ,   Academician Yu.E.Veltishchev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: September 2021

The characteristics of the diet traditionally recommended for Crohn’s disease often reduce patients’ consumption of essential nutrients. Therefore, an important role belongs to nutritional support with specialized formulas, the effectiveness of which has been proven both for inducing remission and optimizing the parameters of physical development and puberty, bone mineralization. Nutritional support should be provided for patients with newly diagnosed Crohn’s disease in the form of full enteral nutrition, and subsequently in remission, exacerbation, in the pre- and postoperative periods as an addition to the standard diet. Of particular interest is the CDED ModuLife program, which is based on a combination of enteral nutrition with specially selected foods aimed at reducing the activity of intestinal inflammation in Crohn’s disease. Key words: inflammatory bowel disease, Crohn’s disease, full enteral nutrition, partial enteral nutrition, enteral nutrition formulas
Alimentary factors affecting the formation of the nutritional status of school-age children
Authors:   Samara State Medical University, Samara, Russian Federation, Sazonova O.V. , Mazur L.I. ,   Samara State Medical University, Samara, Russian Federation, Pyrkova S.A. ,   Samara State Medical University, Samara, Russian Federation, Gavryushin M.Yu. ,   Samara State Medical University, Samara, Russian Federation, Gorbachev D.O. ,   Samara State Medical University, Samara, Russian Federation, Berezhnova O.V. ,   Samara State Medical University, Samara, Russian Federation
Published: September 2021

Objective. To reveal the dependence of the alimentary factor’s influence on the formation of nutritional status disorders in organized groups of school-age children. Patients and methods. A sample questionnaire and an anthropometric survey of 488 school children aged 8–9 years (group 1), 12–13 years (group 2) and 16–17 years (group 3) were conducted. Nutritional status was analyzed by anthropometric measurements using regional modified regression scales for the Samara Region. The analysis of the results obtained, including the risk of nutritional status disorders, was performed with the use of parametric statistical procedures. Results. Hot school meals were provided to 85.6% of pupils in grades 2–3, to 55.6% of sixth graders and 36.4% of pupils in the senior classes. A rational diet was revealed in 18.3% of cases in the junior school group and only in 7.0% of cases in group 3. The consumption of bread and bakery products, vegetables, fruits, milk, and dairy products increases by high school age. The frequency of fish and seafood consumption in most cases in each age group is limited to a few meals per month. Anthropometric studies showed a significant increase in the proportion of children with nutritional status disorders (underweight or overweight) between the ages of 12 and 17. Conclusion. The risk of nutritional status disorders in the examined children was due to the high frequency of consumption of bakery and confectionery products, decreased consumption of fruits and vegetables, and infrequent meals. Key words: school meals, regimen, nutritional structure, nutritional status
A case-based approach to nutritional correction in overweight and obese children and adolescents in outpatient practice
Authors:   Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation, Orlova S.V. , Volkova L.Yu. ,   National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russian Federation, Nikitina E.A. ,   Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation
Published: September 2021

Childhood obesity is one of the major public health problems in the twenty-first century. Up to 90% of all obesity cases in children and adolescents occur in a constitutional exogenous (simple) form. Treatment of obesity in its simple form in children is most appropriate to carry out on an outpatient basis. The main principle of prevention and treatment of overweight and obesity in children is the correction of nutrition and the development of healthy eating behavior. In order to improve the availability and quality of primary health care in the field of “dietetics”, a case-based approach to nutritional correction in overweight and obese children and adolescents has been developed. The proposed case-based approach has a modern scientific and methodological rationale, takes into account time norms for consulting patients during an outpatient appointment, is a plan of thematic consultations for the healthy diet development, ensures a gradual change in patient’s eating habits and individualization of the eating behavior correction, is aimed at the possibility of regular patient monitoring in the treatment process on an outpatient basis and promotes adherence to treatment. The development of the case-based approach is due to the high social significance of obesity, the tendency towards an increase in the number of overweight and obese children and adolescents in the Russian Federation and is aimed at implementing the main directions of the National Projects “Health” and “Demography”. Key words: children and adolescents, dietetics, healthy eating, case-based approach, nutritional correction, obesity, primary health care, eating behavior
Readiness to transition to adult healthcare services among adolescents with chronic kidney disease: a narrative review of international publications
Authors:   N.N.Burdenko Voronezh State Medical University, Voronezh, Russian Federation, E.N.Kulakova E.N.Kulakova ,   Voronezh Regional Children’s Clinical Hospital No 1, Voronezh, Russian Federation, T.L.Nastausheva T.L.Nastausheva ,   N.N.Burdenko Voronezh State Medical University, Voronezh, Russian Federation,   Voronezh Regional Children’s Clinical Hospital No 1, Voronezh, Russian Federation, A.P.Savchenko A.P.Savchenko ,   N.N.Burdenko Voronezh State Medical University, Voronezh, Russian Federation,   Voronezh Regional Children’s Clinical Hospital No 1, Voronezh, Russian Federation, T.G.Zvyagina T.G.Zvyagina ,   N.N.Burdenko Voronezh State Medical University, Voronezh, Russian Federation,   Voronezh Regional Children’s Clinical Hospital No 1, Voronezh, Russian Federation
Published: September 2021

The organization of a successful transition of adolescents with chronic diseases from pediatric to adult healthcare services is an important marker of healthcare quality. Despite the existence of both theoretical and empirical knowledge on this subject, there are still many issues that require further investigation. An evaluation of readiness to transition to adult healthcare services is one such issue. We conducted a narrative review in order to summarize the available data. We selected 43 articles that discuss the definition and meaning of the concept of “readiness” and/or methods and tools for assessing transition readiness in patients with chronic kidney disease (CKD). We found that experts have been studying the transition readiness of adolescents with CKD for more than 30 years. So far, there is no generally accepted definition of this concept. We have identified the following categories of indicators for evaluating adolescents’ transition readiness: clinical, physiological, psychological, social, and cognitive. Seven readiness evaluation tools were also identified, four of which were quantitative (UNC TRxANSITION Scale, RTQ, TRAQ, STARx), i.e. they determined readiness scores; three were qualitative (ON TRAC, Ready Steady Go, Got Transition) and were mainly used to facilitate structured conversations with patients. Further studies are needed to analyze this problem, particularly in the Russian healthcare system. These studies should focus on the development of special criteria of transition readiness and elaborate upon the subsequent integration of this methodology into routine clinical practice. It is important for timely modification of patient management tactics, the prevention of CKD progression, and the improvement of patients’ quality of life. Key words: transition readiness, readiness assessment, transition from pediatric to adult healthcare, adolescents, chronic kidney disease
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 11.09. по 17.09.2021 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: September 2021

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с 11.09. по 17.09.2021 г.
Evaluation of light limitation and depth on germinated seeds of two species of water chestnut cultured under experimental conditions
Authors: Dodd Lynde , Schad Aaron
Published: September 2021

This technical note describes the results of a mesocosm experiment to determine the light and depth limitations of growth chamber germinated seeds of two species of water chestnut (Trapa spp.) naturalized in the northeastern United States.
Intestinal Microbiota Shapes Gut Physiology and Regulates Enteric Neurons and Glia
Authors: Vicentini Fernando A. , Keenan Catherine M. , Wallace Laurie , Woods Crystal , Cavin Jean-Baptiste , Flockton Amanda , Macklin Wendy , Belkind-Gerson Jaime , Hirota Simon , Sharkey Keith A
Published: September 2021

Background: The intestinal microbiota plays an important role in regulating gastrointestinal (GI) physiology in part through interactions with the enteric nervous system (ENS). Alterations in the gut microbiome frequently occur together with disturbances in enteric neural control in pathophysiological conditions. However, the mechanisms by which the microbiota regulates GI function and the structure of the ENS are incompletely understood. Using a mouse model of antibiotic (Abx)-induced bacterial depletion, we sought to determine the molecular mechanisms of microbial regulation of intestinal function and the integrity of the ENS. Spontaneous reconstitution of the Abx-depleted microbiota was used to assess the plasticity of structure and function of the GI tract and ENS. Microbiota-dependent molecular mechanisms of ENS neuronal survival and neurogenesis were also assessed. Results: Adult male and female Abx-treated mice exhibited alterations in GI structure and function, including a longer small intestine, slower transit time, increased carbachol-stimulated ion secretion and increased intestinal permeability. These alterations were accompanied by the loss of enteric neurons in the ileum and proximal colon in both submucosal and myenteric plexuses. A reduction in the number of enteric glia were only observed in the ileal myenteric plexus. Recovery of the microbiota restored intestinal function and stimulated enteric neurogenesis leading to increases in the number of enteric glia and neurons. Lipopolysaccharide (LPS) supplementation enhanced neuronal survival alongside bacterial depletion, but had no effect on neuronal recovery once the Abx-induced neuronal loss was established. In contrast, short-chain fatty acids (SCFA) were able to restore neuronal numbers after Abx-induced neuronal loss, demonstrating that SCFA stimulate enteric neurogenesis in vivo.Conclusions: Our results demonstrate a role for the gut microbiota in regulating the structure and function of the GI tract in a sex-independent manner. Moreover, the microbiota is essential for the maintenance of ENS integrity, by regulating enteric neuronal survival and promoting neurogenesis. Molecular determinants of the microbiota, LPS and SCFA, regulate enteric neuronal survival, while SCFA also stimulates neurogenesis. Our data reveal new insights into the role of the gut microbiota that could lead to therapeutic developments for the treatment of enteric neuropathies.
Studying of Land Cover And Use Maps of South Asia Regions From 2001 To 2015 With AVHRR And MODIS Data
Authors: Ali Shahzad , Qi Huang An , Henchiri Malak , Sha Zhang , Khan Fahim Ullah , Sajid Muhammad , Ali Sajid , Yao Fengmei , Zhang Jiahua
Published: September 2021

In South Asia, annual land cover and land use (LCLU) is a severe issue in the field of earth science because it affects regional climate, global warming, and human activities. Therefore, it is vital essential to obtain correct information on the LCLU in the South Asia regions. LULC annual map covering the entire period is the primary dataset for climatological research. Although the LULC annual global map was produced from the MODIS dataset in 2001, this limited the perspective of the climatological analysis. This study used AVHRR GIMMS NDVI3g data from 2001 to 2015 to randomly forests classify and produced a time series of the annual LCLU map of the South Asia. The MODIS land cover products (MCD12Q1) are used as data from reference for trained classifiers. The results were verified using of the annual map of LCLU time series, and the space-time dynamics of the LCLU map were shown in the last 15 years, from 2001 to 2015. The overall precision of our 15-year land cover map simplifies 16 classes, which is 1.23% and 86.70% significantly maximum as compared to the precision of the MODIS data map. Findings of the past 15 years shows the changing detection that forest land, savanna, farmland, urban and established land, arid land, and cultivated land have increased; by contrast, woody prairie, open shrub-lands, permanent ice and snow, mixed forests, grasslands, evergreen broadleaf forests, permanent wetlands, and water bodies have been significantly reduced over South Asia regions.
COVID-19 Vaccine Acceptability: A Cross-Sectional Mixed Methods Study in Sierra Leone
Authors: Sheku Mahmud , Clemens Ralf , Clemens Sue Ann Costa , Kangbai Jia Bainga , Kargbo Iynnah , Jusu Morison Oliver , Swaray Ibrahim Bob
Published: September 2021

Background: Global immunization is critical to combat the COVID-19 pandemic and the public's willingness to be vaccinated will determine the success of elimination efforts. We measured the acceptability of COVID-19 vaccine and views in Sierra Leone.Method: We used a multi-method study including an online cross-sectional survey and semi-structured interviews to assess the acceptance of and perceptions about COVID-19 vaccination among 2146 Sierra Leoneans aged 18 years and above. Results: Most survey respondents (80.1%, n = 1719) would accept COVID-19 vaccination for themselves and close family,but 19.9% (n = 427) would reject vaccination. If vaccination was mandatory the acceptance rate would increase to 85.0%, (n = 1,823), while 15.0% (n = 318) of responders would still reject. COVID-19 vaccine awareness was high among respondents (yes: 75.2% n = 1613, no: 24.8%, n = 533).Safety, immunity, and trust in vaccines were the main reasons for vaccine acceptance. Distrust, uncertainties about vaccine safety and effectivenessand lack of belief in the COVID-19 pandemic triggered through media reports were the mainreasons for rejecting the COVID-19 vaccination. With respect to vaccine,a small majority would prefer a less reactogenic vaccine even at the cost of a lower efficacy over a more effective but more reactogenic vaccine (55.7%, n = 1195 vs 41.5%, n = 890) while2.8% (n = 61) of respondents said they would reject any vaccine.Country of origin had an important role in vaccine acceptance: 32.4% (n = 1121) would accept a vaccine from any country if licensed locally, but15.1%(n = 511) would rejectvaccines even if licensed from China,12.6% (n = 437), India11.4% (n = 393), USA 8.0% (n = 276), Germany7.8% (n = 271), Russia 7.7% (n = 267), UKand 5.0% (n = 173)from Belgium.Conclusion: Sensitizing the public about the COVID-19 infection risk, vaccine development processesand ensuring vaccine safety through continuous communication and community engagement, with community leaders leading by example as well as the independent role of regulatory authorities in safety and efficacy evaluation, would improve COVID-19 vaccine acceptance.
Rationale And Design of The Learning Implementation of Guideline-Based Decision Support System For Hypertension Treatment (LIGHT) Trial And LIGHT-ACD Trial
Authors: Song Jiali , Wang Xiu-Ling , Wang Bin , Gao Yan , Liu Jia-Min , Zhang Hai-Bo , Li Xi , Li Jing , Wang Ji-Guang , Cai Jun , Herrin Jeph , Armitage Jane , Krumholz Harlan M. , Zheng Xin
Published: September 2021

Background: Computerized clinical decision support systems (CDSS) are low-cost, scalable tools with the potential to improve guideline-based antihypertensive treatment in primary care, but their effectiveness needs testing in pragmatic trials. Methods: The Learning Implementation of Guideline-based decision support system for Hypertension Treatment (LIGHT) trial is a pragmatic, four-stage, cluster-randomized trial conducted in 94 primary care practices in China. For each city-based stage, practices are randomly assigned to either implementation of the CDSS for hypertension management (which guides physicians treatment recommendations based on measured blood pressure and patient characteristics), or usual care. Patients are enrolled during the first 3 months after site randomization and followed for 9 months. The primary outcome is the proportion of hypertension management visits at which guideline-based treatment is provided. In a separate sub-study conducted within the CDSS, with the patient as the unit of randomization, the LIGHT-ACD trial, patients are randomized to receive different initial mono- or dual- antihypertensive therapy. The primary outcome of the LIGHT-ACD trial is the change in blood pressure from the first visit after site randomization to 9 months.Discussion: The LIGHT trial will provide evidence on the effectiveness of a CDSS for improving guideline adherence for hypertension management in primary care in China. The sub-study, LIGHT-ACD trial, will provide data on the effect of different initial antihypertensive regimens for blood pressure management in this setting.Trial registration: ClinicalTrials.gov, identifier: LIGHT (NCT03636334) and LIGHT-ACD (NCT03587103). Registered on 3 July 2018.
The Effects of Dexmedetomidine on the Cognitive Function of Mild Cognitive Impairment (MCI) Rats
Authors: Zhou Qian , Xie Dongjin , Chen Ting , Gao Youguang , Lin Lanying , Lin Xianzhong
Published: September 2021

Background: The study sought to investigate the effects of dexmedetomidine on cognitive function after anesthesia and to examine its actual mechanism. Methods: A total of 48 rats were randomly divided into model Groups A, B, C, or D. Rats in Groups A, B, and C received a hypodermic injection of D-gal with a concentration of 1,000 mg·kg−1·d−1 respectively for 1 week. Group D received the same volume of saline. The Morris water maze (MWM) test was performed within 6 days of the injection. After the behavior test, Group A received an inhalation dose of 2% sevoflurane. Group B received an inhalation dose of 2% sevoflurane and an intraoperative infusion of dexmedetomidine with a concentration of 10 μg·kg−1·h−1. Group C served as the control group and received no treatment. Group D received an inhalation dose of 2% sevoflurane. Results: In relation to the model establishment, we found that there was no significant difference in body weight and swimming speed before and after modeling. There was no statistically significant difference in the escape latency between Groups A, B, C, and D before modeling. After modeling, there was no statistical difference in the escape latency between Groups A, B, and C, but the difference was statistically significant when compared to Group D (P<0.05). In relation to the dexmedetomidine intervention, we found that compared to Group C, MWM test performance in Group A and B was considerably worse (longer escape latencies and fewer platform crossings within 90 seconds), and were more significant in Group A. .Compared with Group D, the levels of IL-1, IL-6, and TNF-α of the brain homogenates were elevated, and this elevation was highest in Group A, followed by Group B; The pathological changes were consistent with changes in behavioral tests. In group A, there were obvious disorders of glial cell arrangement, apoptosis and deletion. There was no significant change in group D. And the changes of vertebral cells in group B and group C were slight, with orderly arrangement and intact cell structure.Conclusions: Dexmedetomidine inhibits the apoptosis of hippocampal cells and reduces the cognitive dysfunction of rats with MCI induced by D-galactose via the inhibition of the release of inflammatory cytokines.
Adipose-Derived Mesenchymal Stromal Cell-Derived Exosomes Alleviate Testicular Torsion Injury via Activation of PI3K/AKT and MAPK/ERK1/2 Pathways
Authors: Liu Hengchen , Shi Manyu , Li Xiangqi , Lu Wenjun , Zhang Mingzhao , Zhang Tingting , Wu Yang , Zhang Zenan , Cui Qingbo , Yang Shulong , Li Zhaozhu
Published: September 2021

Background: Exosomes have became a new therapeutic method in recent years. Adipose-derived mesenchymal stromal cell-derived exosomes (ADSC-Exos) have shown great potential in the treatment of ischemia-reperfusion injury. However, there is no research on whether ADSC-Exos can alleviate testicular torsion injury. Therefore, we investigated the protective effect of ADSC-Exos in alleviating testicular torsion-detorsion injury.Methods: ADSC-Exos were isolated by ultracentrifugation and injected into the torsion-detorsion-affected testes of rats. H&E staining and sperm quality were used to evaluate the therapeutic effects of ADSC-Exos, and the level of tissue oxidative stress was determined using malondialdehyde (MDA) and superoxide dismutase (SOD). In addition, TUNEL staining and immunohistological analyses (Ki67, cleaved Caspase-3, IL-6, IL-10, CCR7, and CD163) were used to clarify the effects of ADSC-Exos on spermatogenic cell proliferation, apoptosis, and the inflammatory microenvironment in vivo. Possible signaling pathways were predicted using sequencing technology and bioinformatics analysis. The signaling pathways were validated by proliferation (EdU), migration (transwell and scratch test), and apoptosis (flow cytometry, TUNEL, and western blot) in vitro.Results: ADSC-Exos alleviated testicular torsion-detorsion injury by attenuating oxidative stress and inflammatory responses. In addition, ADSC-Exos promoted the proliferation and migration of spermatogenic cells and inhibited their apoptosis by activating the PI3K/AKT and MAPK/ERK1/2 signaling pathways.Conclusions: Overall, we demonstrated that ADSC-Exos can alleviate testicular torsion injury and provided a new approach for treating testicular torsion injury.
Apixaban Prophylactic Anticoagulation in Patients With Nephrotic Syndrome
Authors: Meerhaeghe Tess Van , Cez Alexandre , Dahan Karin , Esteve Emmanuel , Elalamy Ismail , Boffa Jean Jacques , Ponlot Eleonore
Published: September 2021

Background

Nephrotic syndrome (NS) is associated with an increased risk of thromboembolic events (TE), due to hemostatic derangements. The use of direct oral anticoagulants (DOAC) in the prevention of TE hasn’t been studied intensively in patients suffering from NS.
Methods

Retrospective analysis of consecutive incident patients with NS due to glomerular disease, receiving apixaban for thrombophylaxis. It is an uncontrolled, single center study.
Results

We identified 27 patients treated with apixaban for the prevention of TE, in the context of NS. During follow-up apixaban Cmin and Cmax levels were measured. The mean duration of the anticoagulant treatment was 153 days (± 132). Patients were followed for a mean of 14.7 months (± 8.4) since the introduction of apixaban. Three patients had a TE at the time of NS diagnosis. Two patients had pulmonary embolism (PE) and one patient presented a stroke in lupus membranous nephropathy context. One patient developed PE approximately 2 months after introduction of apixaban treatment. No minor nor major bleeding events were noticed.
Conclusion

The present study shows that patients, suffering from severe NS under anticoagulant therapy with apixaban had reduced risk of venous and arterial TE compared to patients previously described in the literature, without increased risk of bleeding.
Typology and Characteristics of Indigenous Goats and Production Systems in Different Agro-Ecological Zones of Tanzania
Authors: Nguluma Athumani Shabani , Kyalo Martina , Tarekegn Getinet Mekuriaw , Loina Rose , Nziku Zabron , Chenyambuga Sebastian Wilson , Pelle Roger
Published: September 2021

A study was conducted in all agro-ecological zones in Tanzania to characterize the indigenous goat populations. Qualitative and quantitative data were collected from 688 randomly selected adult female goats. A total of 220 households were interviewed for description of production system. Income generation and meat production were the primary objectives of rearing goats across all the study areas. More than 55% of respondents grazed their animals freely in communal lands where natural pasture was the chief feed resource. Mating was mainly uncontrolled with apron and castration being used by goat keepers as mating control methods. Common diseases were contagious caprine pleural pneumonia and helminthiasis but majority had access to veterinary services and vaccinated their animals regularly. Feed shortage, prevalence of diseases, and water scarcity were the major constraints to goat production. There were morphological variations between and within these goat populations and discriminant analysis clustered the goats into two groups based on quantitative data. Most individuals from Ujiji, Newala, and Tanga goats were correctly classified into their source population, while misassignment was high for other populations. High twinning was observed in Ujiji and Lindi goats and low for Sukuma. The dominant coat color was plain white in Pare, Gogo, Maasai and Tanga. Other coat colour patterns were mixed black and white for Sukuma, reddish-brown for Lindi, black and reddish-brown for Ujiji, white and reddish-brown for Pwani and Maasai. Within and between variation observed is important as it can be used as a basis for genetic improvement through selection and/or crossbreeding.
Distortional Extrema and Holes in the Geometric Manifold
Authors: koehler dale
Published: September 2021

It is shown in the present work that the distorted-space model of matter as extended to extreme curvature limits results in characteristics mimicking those of galactic-holes. The distorted-geometry structures exhibit non-Newtonian features wherein the hole or core-region fields of the structure are energetically-repulsive (negative pressure), do not behave functionally in an r− 4 manner and terminate at zero at the radial origin (no singularity). Of particular interest is that of r− 6 energy-density behavior at structural radial distances near the core of the distortion, a region also displaying potential-well behavior.