bluuebunny/crossref_metadata_2025 huggingface dataset:
Hospital beds and personal protective equipment planning for COVID-19 pandemic: A computer simulation approach
Authors: Lu Yiruo , Guan Yongpei , Fishe Jennifer , Hogan Thanh , Zhong Xiang
Published: June 2020

Health care systems are at the frontline to fight the COVID-19 pandemic. An emergent question for each hospital is how many general ward and intensive care unit beds are needed and how much personal protective equipment to be purchased. However, hospital pandemic preparedness has been hampered by a lack of sufficiently specific planning guidelines. In this paper, we developed a computer simulation approach to evaluating bed utilizations and the corresponding supply needs based on the operational considerations and constraints in individual hospitals. We built a data-driven SEIR model which is adaptive to control policies and can be utilized for regional forecast targeting a specific hospital’s catchment area. The forecast model was integrated into a discrete-event simulation which modeled the patient flow and the interaction with hospital resources. We tested the simulation model outputs against patient census data from UF Health Jacksonville, Jacksonville, FL. Simulation results were consistent with the observation that the hospital has ample bed resources to accommodate the regional COVID patients. After validation, the model was used to predict future bed utilizations given a spectrum of possible scenarios to advise bed planning and stockpiling decisions. Lastly, how to optimally allocate hospital resources to achieve the goal of reducing the case fatality rate while helping a maximum number of patients to recover was discussed. This decision support tool is tailored to a given hospital setting of interest and is generalizable to other hospitals to tackle the pandemic planning challenge.
Bioactive Nanocomposites Composed of Magnesium Oxide Nanoparticles and 58S Bioactive Glass: Synthesis, Characterization, Bioactivity Evaluation and Antibacterial Activity
Authors: Zaferani Seyed Peiman Ghorbanzade , Nabian Nima , Rabiee Sayed Mahmood
Published: June 2020

One of the main strategies to facilitate bone defect healing is the application of a variety of biological materials such as ceramic-based implants and scaffolds. Bioactive glasses are recognized as the favorable biomaterials in bone tissue engineering since they can quickly form a bond with both hard and soft tissues. In this study, novel bioactive nanocomposites based on 58S bioactive glass in composite with various weight percent of magnesium oxide nanoparticles were prepared. DLS measurements represented that 98.1% of 58S glass particles possessed the particle size between 70 and 200 nm. The bioactivity of nanocomposite powders was evaluated through immersion of samples in the simulated body fluid (SBF) at different time intervals of 14 and 28 days. Moreover, the nanocomposite samples were characterized in terms of morphology, phase structure and functional groups using Scanning electron microscopy (SEM), X-ray diffraction and Fourier transform infrared spectroscopy (FTIR) before and after soaking in the SBF solution. It was found that hydroxyapatite was formed on the surface of all nanocomposites after soaking in the SBF solution, although they bioactivity decreased with an increase in the amount of MgO nanoparticles from 15 wt. % to 25 wt. %. Moreover, antibacterial activity of the produced nanocomposites against MRSA bacteria was investigated and the results showed that 58S-15Mg exhibited the highest bactericidal activity.
Different Outcomes of Three Localized Primary Gastric Amyloidosis Cases
Authors: Liu Xuemei , Di Lianjun , Zhu Jiaxing , Wu Xinglong , Li Hongping , Wu Huichao , Tuo Biguang
Published: June 2020

Background: Localized primary gastric amyloidosis is a rare disorder characterized by the extracellular deposition of insoluble fibrillary protein confined to the stomach, which can mimic various diseases, including gastrointestinal stromal tumors, gastric cancer and ulcers in endoscopic examination. Case presentation: Here, we report a series of 3 cases of localized gastric amyloidosis mimicking gastric mucosa-associated lymphoid tissue (MALT) lymphoma by endoscopic examination that were evaluated over the past ten years in our hospital. The different times of detection of this rare disease resulted in three totally different outcomes, indicating the significant importance of the early detection, diagnosis and treatment of this rare disease. The difficulty of making an accurate diagnosis and differential diagnosis is highlighted, and this report may provide more clinical experience for the diagnosis of localized primary gastric amyloidosis.Conclusions: Localized gastric amyloidosis is a rare metabolic disease that can look like MALT lymphoma. Early detection, diagnosis and treatment of this rare disease results in an excellent prognosis.
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19
Authors: Toma Ilario De , Dierssen Mara
Published: June 2020

Background: SARS-CoV-2 has spread uncontrollably worldwide while we still ignore how particularly vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID-19 pandemic. Individuals with DS have more risk of infections with respiratory complications and present signs of auto-inflammation. They also suffer from multiple comorbidities that are associated with poorer COVID-19 prognosis in the general population. All this might place DS individuals at higher risk of SARS-CoV-2 infection or poorer clinical outcomes.Methods: In order to get insight into the interplay between DS genes and SARS-cov2 infection and pathogenesis we retrieved the genes belonging to the molecular pathways involved in COVID-19 and the host proteins interacting with viral proteins from SARS-CoV-2. We therefore analyzed the overlaps of these genes with HSA21 genes, HSA21 interactors and other genes consistently differentially expressed in DS (using public transcriptomic datasets) creating a DS-SARS-CoV-2 network.Results: We detected COVID-19 protective and risk factors that might affect the susceptibility of individuals with DS both at the infection stage and in the progression to acute respiratory distress syndrome.Conclusion: Our analysis suggests that at the infection stage DS individuals might be more susceptible to infection due to triplication of TMPRSS2, that primes the viral S protein for entry in the host cells, even though the anti-viral interferon I signaling is upregulated in DS and this might increase the initial anti-viral response. In the second pro-inflammatory immunopathogenic phase of the infection, the prognosis for DS patients might worsen due to upregulation of inflammatory genes that might favor the typical cytokine storm of COVID-19. We also detected strong downregulation of the NLRP3 gene, critical for maintenance of homeostasis against pathogenic infections, possibly leading to bacterial infection complications.
De novo mutations in GFAP cause Alexander disease: clinical features, fMRI and functional analysis
Authors: Song Xiaoxuan , Jiang Jingwen , Tian Wotu , Zhan Feixia , Zhu Zeyu , Huang Xiaojun , Liu Xiaoli , Li Binyin , Tang Huidong , Cao Li
Published: June 2020

Background: Alexander disease (AxD) is a progressive and fatal neurological disorder characterized by white matter degeneration and Rosenthal fibers inclusions, which was caused by GFAP mutations. Since the first description of AxD, more than 550 cases have been reported. We identified two patients with de novo mutations in GFAP gene causing bulbospinal AxD, and further investigated the pathogenicity of identified variants. Results: Two de novo mutations in GFAP gene were identified (c.214G>A, p.E72K and c.1235C>T, p.T412I) by whole exome sequencing, of which c.1235C>T was the first reported. Clinical assessment revealed that both probands similarly presented bulbar symptoms, pyramidal signs and white matter atrophy in periventricular regions. We conducted a novel data-driven method to analyze fMRI characteristics. Increased brain functional connectivity in occipital and posterior parietal cortex was first discovered in AxD. Grey matter atrophy was also observed in one patient. Functional studies showed that the solubility of p.T412I GFAP was lower than wild type, while p.E72K and p.T412I were at a similar level to wild type, suggesting that mutations located in the tail domain could decrease the solubility of GFAP. Abnormal inclusions of mutant GFAP were colocalized with ubiquitin, 20S proteasome, protein 1 light chain 3-II (LC3-II) and lysosome. Western blotting indicated the ubiquitin-proteasome pathway was blocked while autophagy was activated as a mechanism for degrading aggregates. Conclusions: GFAP mutations identified in our study were associated with AxD and accompanied by protein functional alterations. Our findings further expand the clinical and genetic spectrum of AxD.
Survival Benefit of Patients Aged≥ 75 Years Diagnosed With High-risk Non-metastatic Prostate Cancerafter Definitive Treatmentof the Primary Tumor: A Population-based Study
Authors: Yu JunJie , Xu Bin , Chen Ming
Published: June 2020

Background:The survival benefit of active treatment for high-risk prostate cancer patients aged≥ 75 years remains controversial. We further evaluated the effect of definitive treatment(DT) for those patients in a population-based cohort.Methods:Retrospective analysis of 17848 elderly (≥75 years) men in the Surveillance, Epidemiology, and End Results(SEER) database(2004-2016) who diagnosed non-metastatic high-risk prostate cancer. Kaplan-Meiersurvival curves were used to compare cancer-specific survival (CSS) and overall survival (OS). Propensity-adjusted multivariate Cox regression analysis fitted to identify independent prognostic factors. Logistic regression models were used as a predictor for DT.Results:A total of 17848 patients were identified, 10365 patients receiving DT (including 4284 receiving surgery, 5683 receiving EBRT, 367 receiving BT, 569 receiving EBRT+BT, 92receiving Chemotherapy) and 7473 receiving non-DT. PSM methods wereperformedand compared all baseline factors, including insurance/marital status, age, race,T /N stage, grade, Gleason score(GS),PSA. After PSM, these two groups achieved a median survival time (MST) of 99, 67months for OS, respectively(P<0.01).And older age (age ≥ 80 years) status showed a worse survival benefit (P<0.01). The subgroup analysis illustrated that surgery(MST=122) vsEBRT(MST=111) vs BT(MST=116) vs EBRT+BT(MST=121) subgroups achieved better OS than Chemotherapy group(MST=66)(P<0.01). However, EBRT+BT subgroup had better 3- and 5-year OS (93% and 82.2%). Multivariate Cox proportional hazards model showed unmarried status, older age (age ≥ 80 years), T4 stage, high tumor grade, PSA ≥10 ng/mL were significantly associated with a worse OS, whereas DT (HR, 0.65; p < 0.001) and other race(HR, 0.773; p < 0.001) were associated with a better OS. And logistic regression illustrated that poor differentiated grade was independently predictor (OR=1.427;p=0.022)Conclusions: This study indicated that insurance status, marital status, age, race, T /N stage, grade, GS, PSA and treatment modalities affected OS and CSS in elderly men with non-metastatic high-risk prostate cancer. DT, especially surgery and radiotherapy, might provide favorable OS not CSS compared with NDT for older patients (≥75 years), whereas chemotherapy was not recommended.
Evaluation of a training program for soft skill education and financial literacy to community health workers in India: a quasi-experimental study
Authors: sharma shantanu , Arora Kanishtha , Chandrashekhar Chandrashekhar , Sinha Rajesh Kumar , Akhtar Faiyaz , Mehra Sunil
Published: June 2020

Background

The soft skills of community health workers (Accredited Social Health Activists, ASHA) are known to be effective in negotiating behaviour change in the community; however, there has been a meagre focus towards improving them. Considering this gap, we adopted a comprehensive training program, known as Personal Advancement and Career Enhancement (P.A.C.E.), to empower ASHAs on soft skills and financial literacy. The present study intends to assess the training program in two districts of Uttar Pradesh, India, by examining changes in knowledge, perceptions, and practices of ASHAs about soft skills and financial literacy.

Methods

We conducted a quasi-experimental, non-randomized, controlled study with pre- and post-test assessments. Data were collected on socio-demographic characteristics, knowledge, and practices related to soft skills (communication skills, self-confidence, problem–solving and decision-making skills, time and stress management skills) and financial literacy. Additionally, perceptions regarding changes in practices related to gender issues, soft skills, and savings at the personal, community, and workplace levels were obtained from the intervention group. Factor analysis was performed to obtain the change patterns by assessing the degree to which the four domains of soft skills, financial literacy, and domains of perceptions of change in practices were correlated to each other. A general linear regression model was performed to assess associations among change pattern scores and socio-demographic variables.

Results

The data of 171 ASHAs were analyzed (intervention group:86 and control group:85). There was a significant improvement in the average post-test scores of all the soft skills and financial literacy in the intervention group (p<0.001). Three distinct change patterns were found post-training in the intervention group. Factor 1 (high loadings for perceptions related to change in practices) was positively associated with ASHAs aged 38 years and above and with experience of ≤12 years. On the contrary, the change in financial literacy and self-confidence scores was common among ASHAs with more than 12 years of experience.

Conclusions

The P.A.C.E training program was found effective in improving the soft skills and financial literacy of ASHAs in India.
Evaluation of Drought Tolerance in Arkansas Cowpea Lines at Seedling Stage
Authors: Cui Qirui , Xiong Haizheng , Yufeng Yufeng , Eaton Stephen , Imamura Sora , Santamaria Jossie , Ravelombola Waltram , Mason Richard Esten , Wood Lisa , Mozzoni Leandro Angel , Shi Ainong
Published: June 2020

Cowpea [Vigna unguiculate (L.) Walp.] is not only a healthy, nutritious, and versatile leguminous crop; it also has a relatively high adaptation to drought. Research has shown that cowpea lines have a high tolerance to drought, and many of them can survive more than 40 days under scorching and dry conditions. The cowpea (Southern pea) breeding program at the University of Arkansas has been active for more than 50 years and has produced more than 1000 advanced breeding lines. The purpose of this study was to evaluate the drought-tolerant ability in Arkansas cowpea lines and use the drought-tolerant lines in cowpea production or as parents in cowpea breeding. A total of 36 University of Arkansas breeding lines were used to screen drought tolerance at the seedling stage in this study. The experiment was conducted in the greenhouse using a randomized complete block design (RCBD) with two replicates, organized in a split-plot manner, where the drought treatment (drought and nondrought stress) as the main plot and the cowpea genotypes as the subplot. Drought stress was applied for 4 weeks, and three drought-tolerant–related traits were collected and analyzed. Results showed that cowpea breeding lines: ‘17-61’, ‘17-86’, ‘Early Scarlet’, and ‘ARBlackeye #1’ were found to be drought tolerant.
Propuesta de un algoritmo para la asignación dinámica de espectro en redes ópticas elásticas (EON)
Authors: Ossa Hernández Sebastián David , Vargas Gutiérrez José Alejandro , Gómez Agredo Gustavo Adolfo
Published: June 2020

Este artículo trata sobre el desarrollo e implementación de una nueva propuesta para realizar la asignación dinámica de espectro en una red OPS FlexGrid, mediante un algoritmo voraz basado en el movimiento pendular. Este algoritmo fue implementado en una red con rejillas de ocho y dieciséis slots y también fue comparado con el algoritmo LAUC – VF adaptado a redes RSA, arrojando resultados satisfactorios relacionados con los parámetros de medición, tales como, la probabilidad de bloqueo de la red y el retardo de extremo a extremo. El desarrollo de esta propuesta proporciona una nueva alternativa para la gestión de las redes ópticas elásticas (EON) con asignación de espectro fija en el tiempo.
Investigación orientada a la innovación empresarial y al desarrollo tecnológico
Authors: López Quintero José Germán
Published: June 2020

En este siglo, la investigación es reconocida como valor transformacional del sector productivo. En dicho contexto, es posible entender el rol que juega la investigación como elemento constituido primordial, para la innovación de productos, procesos y servicios destinados a empresas ya establecidas e incluso a proponer nuevos negocios de base tecnológica, además de ser reconocida como un elemento clave para solucionar problemas dentro de la sociedad.
Risk Factors Affecting the Performance of Construction Projects in Gaza Strip
Authors: Tayeh Bassam A. , Salem Tareq J. , Abu Aisheh Yazan I. , Alaloul Wesam S.
Published: June 2020

Background:

The construction industry is generally associated with a high level of risk and ambiguity because of the nature of its working contexts. In the Gaza Strip, construction projects are among the riskiest projects, which require the application of the right rules and adherence to the proper management standards. Identification of these risks is the first step in risk management.

Aims:

This study aims to investigate and understand the main risks faced by the construction projects in the Gaza strip.

Methods:

A questionnaire survey was conducted to achieve the study aim, whose applicability was tested through a pilot study. Using targeted participants from engineering offices and consulting engineering companies, 70 questionnaires were distributed and collected with a response rate of 85.71%. The Quantitative method was used for data analysis using SPSS. 38 risk factor statements were considered from the seven clusters of risk factors.

Results:

The results show that the political risk factor was determined to be the highest with a Relative Important Index (RII) of 75.47%, while the design factor was the least factor with an average RII of 61.89%.

Conclusion:

It is recommended that companies should appoint a specialist in the field of risk management.
The Writer as Reporter: Portraiture in Literary Reportage and Documentary Writing
Authors: Boyd Maunsell Jerome
Published: June 2020

This article explores how several novelists in the first half of the twentieth century, including James Agee, Jack London, George Orwell, and John Steinbeck, portrayed other, often marginal, real lives in works of reportage and documentary writing—terms variously defined and utilised by critics and practitioners, but seen here as hybrid, intersecting forms of life writing. It argues that such work has an extremely artful element of verbal portraiture of real-life people, often in dialogue with photography. The process of writing and witnessing reportage work differs substantially from that of fiction. Focusing on certain factors key to the portraiture in reportage—including unfamiliarity, representativeness, standpoint, and objectivity—the article analyses these writers’ treatment of them. The extent to which these writers revealed their documentary or reportorial role to their subjects, or disguised it, is also considered. Moving between international, cultural, political and social contexts, and deeply informed by chance and accident, early twentieth century reportage emerges as a highly interactive, volatile, and intersubjective space in its portraiture of others, nonetheless defined finally by the writer’s point of view.
My Poyln
Authors: Herbst Marcel
Published: June 2020

The note of My Poyln was written as an introduction to a planned photography book regarding a Jewish past that is cleansed from its erstwhile meaning, desolated, and mourned. The thrust to research and photograph a former time grew slowly, over many years. My reading of the Holocaust is one of grief about the denial of the past (and a more humane future) and the lost cross-ethnic, rich culture. That theme I follow in writing and photography—next to my more normal concerns relating to more mundane matters—see: www.4mat.ch.
The lowering of high vowels before [r] in Latin
Authors: Cser András
Published: June 2020

This paper discusses a putative sound change in the early history of Latin and synchronic alternations apparently related to it. The lowering of short high vowels before the rhotic is problematic on several counts; so much so that serious doubt has been cast on its reality. On the other hand, due to widespread alternations in the morphophonology of Classical Latin it is reasonable to assume that such a lowering operated as a synchronic rule at that stage. A minor asymmetry in the relevant alternations of verbal affixes in infectum-based vs. perfectum-based formations presents an interesting problem to which I suggest two tentative explanations.
Improving High School and Vocational School Teachers in Writing Skill
Authors: Surya Awang , Azharul Firmansyah , Wilarso W. , Idris Mustopa , Azziqi Yusril Zindar , Retno Iwung Hari
Published: June 2020

Sekolah Tinggi Teknologi Muhammadiyah Cileungsi has the duty of the College Dharma Chess which includes education and teaching activities, research and community service, and AIKA and Al-Islam. The purpose of this research is to teach writing methods to teachers, to facilitate teaching and learning. The method used in this research are identification of the problem, conduct a field survey, finding material, and direct training  to representatives of each high school / vocational school teachers. In this training participants were given the easiest writing method. From telling great writers in life in the world, where they can exist in writing. Then the participants were asked to write an article to get used to writing. After the end of the activity, participants are asked to share in the group or discuss directly with the speaker, so that the writing that has been made can be immediately reviewed. Solutions in writing training, taking the time to write, and frequent discussions with people who often write. The result of this research is the teachers know writing techniques to develop teaching activity in the classroom.
RELATIONSHIP HUSBAND’S SUPPORT WITH NUTRITIONAL STATUS OF INJECTABLE CONTRACEPTIVES ACCEPTOR
Authors: Ambarwati Nining , Armini Ni Ketut Alit , Krisnana Ilya
Published: June 2020

Hormonal contraception type injectable contraceptives increasingly popular in Indonesia because of its practical, cost-effective, and safe. Side effects of use injectable contraceptives is changes in nutritional status. Nutritional status is a measure in the assessment of nutritional fulfillment that reflects a person's health status. Changes in nutritional status are multifactorial like husband’s support. This study aims to explain the relationship between husband’s support with nutritional status on injectable contraceptives acceptor. This study used cross sectional design. The sample in this research is women of childbearing age who use injectable contraceptive of Puskesmas Gading Surabaya region obtained by purposive sampling technique. Independent variable is husband’s support. The dependent variable is the nutritional status of injectable contraceptives acceptor. The instruments in this study were questionnaires and BMI measurements. To find out the relationship, this study uses Spearman correlation test. Husband’s support with nutritional status on injectable contraceptives acceptor, obtained result p = 0,00 (r) = -0,546. The husband’s support with nutritional status on injectable contraceptives acceptor has a moderate correlation with negative correlation coefficient, it means that less respondents get support from their husbands, nutritional status will increase until they get overweight or obese. It is necessary to increase the involvement of husbands in deciding the use of contraception, so women of childbearing age of injecting contraceptives acceptor receives adequate husband’s support.
EFFECT OF COMBINATION PURSED LIP BREATHING AND GUIDED IMAGERY MUSIC ON PEAK EXPIRATORY FLOW PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Hariyono Rudi , Soedarsono Soedarsono , Makhfudli Makhfudli
Published: June 2020

ABSTRACTBackground: Peak expiratory flow influenced by several things, such as anxiety, a psychological factor that is becoming a major comorbidities of COPD and affect the occurrence of exacerbations, increase respiration rate, duration expiratory time, and hyperinflation. This study aimed to determine the effect of combination pursed lip breathing and guided imagery music to increase  value of peak expiratory flow in patients with COPD. Methods: The study was quasi-experimental design with pretest posttest with control group approach, respondents of this study is 46 patients with COPD with sampling technique, simple random sampling. Results: Pursed lip breathing increase peak expiratory flow values by the significant of p value = 0.000 (p <0.05). The combination of pursed lip breathing and guided imagery music increase peak expiratory flow values by the significant of p value = 0.000 (p <0.05). COPD patients who received a combination of pursed lip breathing and guided imagery music increased peak expiratory flow value higher than the pursed lip breathing without combination with significant of p value = 0.000 (p <0.05).Conclusion:The combination of pursed lip breathing and guided imagery music proved to have an effect on increasing the value of peak expiratory flow higher than pursed lip breathing without combination.
Identification of Physical Activities in Post Stroke Patients
Authors: Agustiyaningsih Titik , Marta Ollyvia Freeska Dwi , Mashfufa Erma Wahyu
Published: June 2020

Introduction: The incidence of recurrent strokes is increasing accompanied by the absence of intensive monitoring of physical activity that needs to be more addressed. The aims of intensively monitoring of physical activity to reduce disruption/ disability for life, to decrease the economic burden of the family, and to reduce the risk of death in stroke patients. Objectives: The purpose of this study was to determine the physical activity of patients after stroke attack. Method: We used an observational study design by case control approach, without giving certain treatment to the subjects of this study. We collected the demographic data from the participants and the International Physical Activity Questionnaire was used to measure the physical activity. The study was conducted at Aisyiyah Islamic Hospital in Malang, the average population was 30 people per month and samples were taken using purposive sampling technique. Data was collected by IPAQ questionnaire consisting of activities carried out around the house, activities at work and recreation activities and observation sheets. Results: The results showed that most physical activity of stroke sufferers was in the mild category (68.3%. Dicussion: It is recommended that respondents continue to do physical activity to reduce the prevalence of stroke recurrence.
A Quantitative Test between Formalin Fresh and Boiled Fish at the Fish Market in Tulungagung
Authors: Setyowati Lilis , Purwanto Edi , Ningtyas Nurmala Agustin
Published: June 2020

Introduction: Fish is one of the sources of animal protein that many people look for because it is readily available and affordable. Nowadays, found in many traditional markets of traders, fish managers use formalin to preserve their wares. Objective: The purpose of this study was to determine differences in levels of boiled and fresh fish in TPI Tulungagung. Design quantitative analytic research studies cross-sectional. Quantitative formalin test with Formalin Kit returns UV-Vis spectrophotometer in the Biomedical Laboratory FK UMM, and Mann-Whitney test. The study population of fresh and boiled fish taken from 3 TPI in Tulungagung. The sampling technique was random sampling, each with four samples. Result: The results showed that the average value of formalin in boiled fish was 1.63 mg / ℓ and fresh 4.54 mg / ℓ. There was a significant difference in formalin levels in boiled fish and fresh fish (p) <0.001. The samples from TPI Tulungagung contaminated formalin. However, the content of formalin in fresh fish is higher than boiled fish. It is very high from the BPOM standard. Discussion: The public is more concerned with the abuses committed, especially the use of formalin in circulation.
The Relation between Fatigue and Self-management in Patient with Diabetes Melitus Type 2 in Dr Soebandi Hospital Jember
Authors: Yazid Syahrul Abdul , Sutawardana Jon Hafan , Siswoyo Siswoyo
Published: June 2020

Introduction: Fatigue that felt by diabetes melitus patient will be a barrier when doing self-management. An ineffectiveness of self-management will affect many complications, either macrovascular and microvascular. Objective: The goal of this research is determine the relation of fatigue and self-management of diabetes melitus type 2. Method: The design of this research is using observative correlative with cross – sectional way. There are 102 research samples obtained from the calculation G*Power. The methode of taking the data doing with way to gather use with Multidemensional Fatigue Inventory (MFI20) questionnaire and Diabetes Self-Management (DSMQ) that has tested validity and realibility for analyze the fatigue and self-management. The data from analyzed using spearman rank (α = 0,05). Results: Research’s result average of respondent showed that general fatigue (15,66), physical fatigue (13,8), reduced activity (12,44), reduced motivation (11,01), mental fatigue (11,37). Patient self-management showed if from 102 respondent in majority has good self-management 86 (84.3%) dan 15 (14,7%) the rest of respondent has enough – good. The second analyzed test showed that no relation that significant between fatigue and self-management. Discussion: There are other factor can influence self-management such as, social support and family support. Analyzed test showed if have corelation between reduce activity with managemen glukosa
Industrial relations climate and employee intention to quit: The roles of voice and silence
Authors: Jiang Yongzhong , Yao Yi
Published: June 2020

Using social influence theory, we examined a model regarding the mediating effects of voice and silence in the relationship between industrial relations climate and employee intention to quit. Data were collected at 2 time points from 536 frontline employees at firms in an industrial
park in China. We tested the hypothesized relationships using multiple mediation structural equation modeling and bootstrapping analysis. The results demonstrate that harmonious industrial relations climate reduced intention to quit by increasing employee voice, and hostile industrial relations
climate increased intention to quit by increasing employee silence. Our findings highlight the importance of the roles of employee voice and silence in the relationship between industrial relations climate and employee intention to quit.
Pode o subalterno mapear e incidir no planejamento regional? Conflitos territoriais e disputas cartográficas no ordenamento fundiário do oeste do Pará
Authors: Ficher Teixeira Assis Wendell
Published: June 2020

O ato de mapear é um exercício de poder que, simultaneamente, representa e nomeia o espaço. No intuito de elucidar como o aparato cartográfico tem sido utilizado em disputas territoriais, este artigo se dedica à análise do ordenamento fundiário conduzido pelo Governo do Pará no conjunto de glebas Mamuru-Arapiuns no final dos anos 2000. A ideia é compreender como se desenrolou a destinação de terras e analisar as formas de atuação das populações tradicionais e dos movimentos sociais na construção de uma proposta contra-hegemônica de uso e apropriação dos territórios. Ademais, busca-se entender como os mapas participativos são elaborados e utilizados nesse contexto de disputa territorial e cartográfica. Para tanto, lança-se mão de levantamentos bibliográficos e da realização de trabalhos de campo. As disputas materializadas nos mapas refletem um terreno onde o conflito se processa por meio da incomensurabilidade de interesses, por sua vez, orientados pela forma como a natureza é significada e utilizada material e simbolicamente.
ANALISIS EKONOMI ISLAM TERHADAP BAGI HASIL PEMBIAYAAN MUDHARABAH UNTUK USAHA MIKRO PADA BAITUL QIRADH ABU INDRAPURI
Authors: Jumadi Jumadi
Published: June 2020

This study generally aims to analyze the concept of mudharabah financing in Baitul Qiradh (BQ) Abu Indrapuri for micro-enterprises. Specifically, the paper reviews the systems implemented in the management and revenue-sharing mechanisms derived from these micro-enterprises. This study employs primary and secondary data which were collected through interview and documentation studies. The data were analyzed using descriptive analysis method. The findings show that generally the concept of mudharabah financing in BQ Abu Indrapuri is based on Fatwa Dewan Syariah Nasional No. 07/DSN/MUI/IV/2000. In the implementation level, however, the application of profit sharing and collateral system was not fully shariah compliance. The imbalance between the concept and implementation because the BQ still refers to the conventional banking rules.

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Penelitian ini secara umum bertujuan untuk menganalisis konsep pembiayaan mudharabah pada Baitul Qiradh (BQ) Abu Indrapuri untuk usaha mikro. Secara spesifik, tulisan mengkaji tentang sistem yang diterapkan dalam pengelolaan dan mekanisme pembagian pendapatan yang diperoleh dari usaha mikro tersebut. Penelitian ini menggunakan data primer dan sekunder yang dikumpulkan dengan teknik wawancara bebas, dan studi dokumentasi. Data yang diperoleh dianalisis dengan menggunakan metode deskriptif analisis. Hasil penelitian menunjukkan bahwa secara umum konsep pembiayaan mudharabah pada BQ Abu Indrapuri berpedoman pada Fatwa Dewan Syariah Nasional No.07/DSN/MUI/IV/2000. Akan tetapi, dalam implementasinya masih terdapat hal-hal yang tidak sesuai dengan konsep syariah yaitu pada sistem bagi hasil dan jaminan. Terdapat ketimpangan antara konsep dan implementasi disebabkan karena BQ Abu Indrapuri masih mengacu pada aturan sistem perbankan konvensional.
Margarida Vale de Gato: apresentação de ‘Mulher ao mar’ e entrevista
Authors: Pequeno Tatiana
Published: June 2020

O presente texto objetiva introduzir o leitor na poesia da escritora portuguesa Margarida Vale de Gato a partir de questões relacionadas às temáticas feministas, de gênero e sexualidade considerando, para tanto, seu projeto poético intitulado Mulher ao mar, publicado pela primeira vez em 2010. Contém ainda uma breve entrevista feita com a poeta no final de 2017.
PENGARUH PROFITABILITAS, STRUKTUR MODAL, DAN KEPUTUSAN INVESTASI TERHADAP NILAI PERUSAHAAN (PADA SEKTOR FARMASI YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2013-2017)
Authors: Oktiwiati Eka Dela , Nurhayati Mafizatun
Published: June 2020

This study aims to determine the effect of Profitability, Capital Structur, and Investment Decision to company values. This population is pharmacist companies of Indonesia Stock Exchange on periode 2013 to 2017. The research design is causal research. The sampling technique is purposive sampling method. The method derived 6 companies that meet the criteria from 9 companies during the observation period of five years. Total sampel are 30 sample. The analysis technique used is the panel data regression. The results showed that profitability has positive and significant influence towards the firm value, while the capital structure has positive and significant towards the firm value. And the investment decision has positive and significant influence towards the firm value.
O TRATO COM O CONHECIMENTO DA GINÁSTICA EM CLASSES MULTISSERIADAS: APONTAMENTOS DA PEDAGOGIA HISTÓRICO-CRÍTICA E DA METODOLOGIA DO ENSINO DA EDUCAÇÃO FÍSICA CRÍTICO-SUPERADORA PARA O CURRÍCULO DAS ESCOLAS PÚBLICAS
Authors: Taffarel Celi Nelza Zulke , Costa Cláudio Dos Santos , Vilas-Bôas Júnior Jaildo Calda dos Santos
Published: June 2020

O texto tem como objetivo identificar as contribuições teórico-metodológicas da Pedagogia Histórico-Crítica (PHC) e da Abordagem Crítico-Superadora (ACS) para o trato com o conhecimento da Ginástica, em classes multisseriadas, nas escolas públicas do campo. Partindo da realidade concreta das escolas que estão sendo fechadas em decorrência da aplicação da política baseada em ajustes estruturais e da negação sistemática do acesso ao conhecimento clássico, na disciplina Educação Física, para os estudantes do campo, estamos apresentando elementos teórico-metodológicos advindos da PHC e da ACS para subsidiar o trabalho educativo e suas possibilidades superadoras no trato com o conhecimento da Ginástica.
A EXPERIÊNCIA EDUCACIONAL DOS ATLETAS NOS JOGOS OLÍMPICOS DA JUVENTUDE: UMA REVISÃO SISTEMÁTICA
Authors: Souza Adriano Lopes de , Tavares Otávio
Published: June 2020

O objetivo do presente estudo é compreender o que vem sendo produzido na literatura nacional e internacional a respeito da participação dos jovens atletas de elite no Jogos Olímpicos da Juventude, com foco na sua experiência educacional. Para tanto, realizamos uma revisão sistemática qualitativa. As buscas foram realizadas em cinco bases de dados diferenciadas, a partir das quais selecionamos sete artigos em consonância com os critérios de inclusão e exclusão. Os resultados apontaram que a participação nos YOG pode promover um conjunto de aprendizagens valorativas aos jovens atletas. Entretanto, tais experiências educacionais parecem materializar-se muito mais a partir de reuniões e interações socioculturais de caráter informal entre eles. Conclui-se que o sucesso deste novo megaevento não reside em replicar os Jogos Olímpicos como preparação da juventude para atuar nas edições adultas, mas na sua capacidade/potencialidade para equilibrar mais claramente a tríade esporte-competição-educação.
A patient-level model to estimate lifetime health outcomes of patients with type 1 diabetes
Authors: Tran-Duy An , Knight Josh , Palmer Andrew J , Petrie Dennis , Lung Tom WC , Herman William H , Eliasson Björn , Svensson Ann-Marie , Clarke Philip M
Published: June 2020

OBJECTIVE

To develop a patient-level simulation model for
predicting lifetime health outcomes of patients with type 1 diabetes and as a
tool for economic evaluation of type 1 diabetes treatment based on data from a
large, longitudinal cohort.

RESEARCH DESIGN AND METHODS

Data for model development were obtained from the Swedish National Diabetes Register. We derived
parametric proportional hazards models predicting absolute risk of diabetes
complications and death based on a wide range of clinical variables and history
of complications. We used linear regression models to predict risk factor
progression. Internal validation was performed, estimates of life expectancies
for different age-sex strata were computed, and the impact of key risk factors
on life expectancy was assessed.

RESULTS

The study population consisted of 27,841 patients with type
1 diabetes with a mean duration of follow-up of 7 years. Internal validation
showed good agreement between predicted and observed cumulative incidence of death
and 10 complications. Simulated life expectancy was approximately 13 years
lower than that of the sex- and age-matched general population, and patients
with type 1 diabetes could expect to live with one or more complications for approximately
40% of their remaining life. Sensitivity analysis showed the importance of preventing
renal dysfunction, hypoglycaemia and hyperglycaemia, and lowering HbA1c in
reducing the risk of complications and death.

CONCLUSIONS

Our model was able to simulate risk factor progression
and event histories that closely match the observed outcomes, and project events
occurring over patients’ lifetimes. The model can serve as a tool to estimate
the impact of changing clinical risk factors on health outcomes to inform
economic evaluations of interventions in type 1 diabetes.
Need Assessment Of Learning Inclusive Program For Students In Nonformal Of Early Childhood Education
Authors: Putra Ari
Published: June 2020

The concept of the inclusive program is an organized according to the ability and needs of students with the aim of learners to be successful and can optimize the potential within themselves. Currently, the inclusive program is newly embodied in formal education programs such as elementary, junior, and senior high schools. The current problem does not clear the maturity of the concept of the inclusive education program in non-formal education, especially in non-formal of early childhood education. This study aims to find out how the assessment process done by teachers in Bunayya Islamic preschooler finding out the source of learning needs such as students with special needs. The research method used is the qualitative method by using triangulation of subject, time, and place. The result of this research show that Bunayya Islamic preschooler make an initiative to create their own learning concepts without technical guidance such as inclusive curriculum development and lesson plans. Bunayya Islamic preschooler runs the learning program by planning, implementing and evaluating the needs of learning resources of children with special needs. The conclusion of this study are the teacher performs several steps such as the identification of special needs children, pre-qualification priorities and the development of the learning curriculum to adopted the learning interpretation and alternative program for preschoolers and parent’s concepts
Arts and Crafts: Fun Activities to Train Early Childhood Cooperation
Authors: Azhima Idzni
Published: June 2020

Abstract : Cooperation is one form of an aspect of social emotional development that needs to be developed in early childhood to be able to have a collaborative attitude, interact with other people and have an attitude of responsibility for their work. Learning methods that can be used in an effort to improve the ability of child cooperation, namely by group work methods. In this study, group work was applied based on playing art and craft activities. The purpose of writing this article is to add an alternative method of learning to improve collaboration skills in early childhood.
School Readiness of Preschool Children Entering Elementary School Based on Nijmeegse Schoolbekwaamheids Test (Nst) (Case Study at Early Childhood Education Al Husna Pengging Boyolali In 2017)
Authors: Fauziyah Nur
Published: June 2020

This is descriptive research to find out school readiness in terms of N.S.T (Nijmeegse Schoolbekwaamheids Test) test results. Research uses quantitative approach. Subject of the research is students of early childhood education Al Husna Kindergarten B level in Pengging Boyolali which will enter elementary school. Number of research subject is 32 students. Measuring instrument used on the research is N.S.T (Nijmeegse Schoolbekwaamheids Test) and also observation. Analysis of data will be done quantitatively with simple statistic technique. Result of the research shows that from 32 students, 50% stated has readiness as much 16 students, 40,6% is quite ready as much 13 students meanwhile not ready is 9,4% as much 3 students.The most prominent aspect in its level of maturity is aspect of form observations and the ability to distinguish which is 84,4% for 27 students. The least aspect on the task of understanding the story is 25% for 8 students. Qualitatively, school readiness aspect from cognitive aspect is observation and the ability to distinguish, notions of big, number and comparison, concentrate and memory already reaches a fairly optimal level of maturity. Meanwhile related aspect with understanding stories and pictures of people skill the level of preparedness is not yet optimal.
KEPEMIMPINAN DAN PROMOSI JABATAN DAN KINERJA KARYAWAN (STUDI KASUS: PERUSAHAAN UMUM (PERUM) JAMINAN KREDIT INDONESIA KANTOR CABANG PEKANBARU)
Authors: KUSDIANA YAYU , ANGGRIANI IRIEN VIOLINDA
Published: June 2020

ABSTRAK  YAYU KUSDIANA, NIDN: 1006067701 dan IRIEN VIOLINDA ANGGRIANI, NIDN: 2006117501 Pengaruh Kepemimpinan Dan Promosi Jabatan Terhadap Kinerja kinerja karyawan pada Perum Jamkrindo Kantor Cabang Pekanbaru.Tujuan penelitian ini untuk mengetahui pengaruh Kepemimpinan Dan Promosi Jabatan Terhadap Kinerja kinerja karyawan pada Perum Jamkrindo Kantor Cabang Pekanbaru.Metode dalam penelitian ini menggunakan metode deskriptif kuantitatif.Penelitian ini menggunakan populasi sensus, yaitu seluruh jumlah populasi dijadikan sampel.Sampel dalam penelitian ini sebanyak 44.Uji hipotesis terdiri dari uji F, dan uji T. Berdasarkan hasil uji F terbukti bahwa kepemimpinan dan jabatan promosiimemiliki pengaruh dengan tingkat signifikan 0,00 terhadap kinerja karyawan pada Perum Jamkrindo Kantor Cabang Pekanbaru, ditunjukkan dengan nilai Fhitung lebih besar dari Ftabel(59,887>3,23) dengan tingkat signiikan 0,000 < 0.05, sedangkan hasil uji koefisien determinasi (R2) diperoleh nilai adjusted R square sebesar 0,733 atau 73,3% yang artinya kpeemimpinan dan promosi jabatan memiliki pengaruh terhadap kinerja karyawan pada Perum Jamkrindo Kantor Cabang Pekanbaru dan sisanya sebesar 26,7% dipengaruhi oleh faktor lain.Berdasarkan uji T terbukti bahwa kepemimpinan berpengaruh signifikan terhadap kinerja karyawan pada Perum Jamkrindo Kantor Cabang Pekanbaruditunjukkan dengan nilai thitung lebih besar dari ttabel (3,636>1,68195)dan promosi jabatan berpengaruh dengan tingkat signifikan 0,000terhadap kinerja karyawan pada Perum Jamkrindo Kantor Cabang Pekanbaru ditunjukkan dengan nilai thitung lebih besar dari ttabel (8,538>1,68195).
Устойчивость карбапенемрезистентных штаммов Klebsiella pneumoniae к колистину: молекулярные механизмы и бактериальный фитнес
Authors: Шамина О. В. , Крыжановская О. А. , Лазарева А. В. , Алябьева Н. М. , Маянский Н. А.
Published: June 2020

В последние годы широкое использование колистина в лечении инфекционных заболеваний привело к появлению и распространению колистинрезистентности. По данным литературы, формирование устойчивости может приводить к затратам внутренних биологических ресурсов и снижению уровня приспособленности и поддержания жизнедеятельности (бактериального фитнеса). Целью исследования было изучить молекулярные механизмы резистентности к колистину и их влияние на бактериальный фитнес карбапенемрезистентных (карба-Р) штаммов K. pneumoniae, выделенных у пациентов в г. Москве в 2012–2017 гг. Из 159 карба-Р-изолятов 71 изолят (45%) обладал резистентностью к колистину (минимальная подавляющая концентрация больше 2 мг/л); секвенирование по методу Сенгера позволило обнаружить механизмы устойчивости у 26 (37%) изолятов. Кривые роста были построены путем измерения оптической плотности при длине волны 600 нм в течение 15 ч. Конкурентный рост колистинрезистентных (кол-Р) изолятов K. pneumoniae оценивали относительно колистинчувствительного (кол-Ч) изолята. Кол-Р- и кол-Ч-изоляты в экспоненциальной фазе роста смешивали в пропорции 1 : 1, инкубировали в среде Луриа–Бертани и затем наносили на агар Луриа–Бертани, содержащий 10 мг/л колистина, и без него. Индекс конкуренции рассчитывали как отношение выросших кол-Р- и кол-Ч-колоний. Резистентность к колистину не влияла на кинетику роста K. pneumoniae, но снижала конкурентоспособность относительно кол-Ч-изолята. Тем не менее были обнаружены кол-Р-изоляты с высоким уровнем конкурентоспособности по сравнению с кол-Ч-изолятами такого же сиквенс-типа. Таким образом, необходимы дальнейшие исследования влияния резистентности к колистину на бактериальный фитнес.