bluuebunny/crossref_metadata_2025 huggingface dataset:
Dampak Aspek Capital, Assets, Earning, dan Liquidity Pada Kesehatan Keuangan Perbankan
Authors: Hayatie Marliza Noor , Alam Sur Widiya Astuti , Gautama Muhammad Shapiq
Published: October 2020

Perbankan memiliki pengaruh yang besar terhadap perekonomian dalam perannya di sebuah negara, sehingga bank dijadikan gambaran kemajuan sebuah negara. Rasio yang digunakan untuk menilai kesehatan keuangan perbankan pada penelitian ini adalah CAEL (Capital, Assets, Earning, Liquidity). Salah satu indikator yang dipakai untuk mengukur tingkat kesehatan keuangan suatu bank adalah Return On Assets (ROA). Data kuantitatif dalam penelitian ini adalah data laporan keuangan pada perusahaan perbankan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2018. Dari penelitian yang dilakukan dapat disimpulkan bahwa rasio BOPO (Biaya Operasional/ Pendapatan Operasional) dari aspek pendapatan, lebih dominan pengaruhnya terhadap Return On Assets (ROA) jika dibandingkan dengan rasio CAR (Capital Adequacy Ratio) dari aspek permodalan, Rasio NPL (Non Performing Loan) dari aspek harta, Rasio LDR (Loan to Deposit Ratio) untuk aspek likuiditas.
Pengaruh Current Ratio, Debt To Equity Ratio dan Return On Equity Terhadap Harga Saham (Studi Pada PT. Lippo Cikarang, Tbk Periode 2014-2019)
Authors: Arista Finti , Musadad Anwar
Published: October 2020

Penelitian dilakukan dengan menggunakan metode deskriptif dan verifikatif, yaitu: mengumpulkan,  menyajikan,  menganalisis,  dan  melakukan  pengujian  hipotesis,  serta membuat  kesimpulan  dan  saran.  Sampel  dikumpulkan  menggunakan metode Purposive Sampling menggunakan 24 data keuangan dari laporan keuangan PT. Lippo Cikarang, Tbk dari selama periode 2014-2019. Teknik analisis data menggunakan teknik  Analisis Regresi Linier Berganda dan Analisis Koefisien Determinasi. Adapun hasil penelitian menyatakan bahwa CR, DER dan ROE berpengaruh terhadap Harga Saham PT. Lippo Cikarang, Tbk selama periode 2014-2019 sebesar 61,8%.
NUMERICAL SOLUTION OF NONLINEAR EQUATIONS IN ELECTRONIC TABLES AND VISUAL BASIC FOR APPLICATIONS
Authors: Korolev A. L.
Published: October 2020

The article discusses some methods for numerically finding the roots of nonlinear equations, which are determined by numerical methods using the construction of a spreadsheet Microsoft Excel and an application in the Visual Basic for Applications environment. The simplest methods are used: the binary division method and the chord method. The article presents the construction of spreadsheets, the algorithm, the method of creation the VBA application, and the text of the corresponding procedures. The material of the article can be used in informatics courses, both at school and at university, for the development of interdisciplinary connections between informatics and mathematics and expanding ideas about the possibilities of spreadsheets. The problems presented in the article were successfully solved by 10th grade students (profile "Mathematics. Informatics") and first-year students of pedagogical university of the profiles "Physics. Mathematics", "Physics. Informatics". The article reflects the author's personal experience of teaching the course "Informatics" at South Ural State University of Humanities and Education and at school.
METHODS FOR CONSTRUCTING AND IMPLEMENTING A DIGITAL GEOINFORMATION MODEL USING MS EXCEL IN A SCHOOL INFORMATICS COURSE
Authors: Nazarov D. M. , Kovtun D. B.
Published: October 2020

The article describes a methodology for teaching the technology of constructing a geoinformation model using MS Excel. This methodology is built taking into account the Federal State Educational Standard of Secondary General Education and the requirements provided for in the implementation of the approximate educational program of the course "Informatics" along the line "Modeling and Formalization". The authors proposed a laboratory work, within which the students, firstly, learn the new capabilities of the MS Excel package, associated with the use of Power Query and 3D Maps technologies; secondly, they get the initial skills in processing "raw" data in real time; thirdly, they learn the modeling process, in fact, without going beyond the competence of the school informatics course. In general, the laboratory work describes the technology of geoinformation modeling of real processes and has great variability, and therefore can be easily adapted for research and visualization of other updated data. The format for describing the methodology for performing laboratory work is presented in the form of the traditional Key-by-Key technology, which is widely used in obtaining professional competencies in the field of information technology.
UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA)
Authors: Karim Fatmawati , Susilawati Susilawati , Oswari Liniyati D , Dzakiyah Dzakiyah , Anindita Fahira
Published: October 2020

Penelitian ini menggunakan ekstrak akar kayu kuning (Arcangelisia flava) untuk melihat aktifitas sebagai antidiabetes yang dapat menurunkan kadar glukosa darah tikus putih jantan (Rattus novergicus) galur wistar yang diinduksi aloksan. Rancangan penelitian ialah studi eksperimental secara in vivo dengan pendekatan post test with control group design. Penelitian ini menggunakan 70 ekor tikus dan dibagi secara acak menjadi 14 kelompok dengan jumlah tikus lima ekor perkelompok yaitu kontrol negatif (NaCMC 0,5%), kontrol positif (acarbose 4,5 mg/kgBB), ekstrak heksana akar kayu kuning(dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB), ekstrak etil asetat akar kayu kuning (dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB), ekstrak etanol akar kayu kuning (dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB), dan ekstrak aquades akar kayu kuning (dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB). Seluruh kelompok diinduksi dengan aloksan 160 mg/kgBB sehingga mempunyai glukosa darah sewaktu ≥200 mg/dL (pretest). Setelah 15 hari diberi perlakuan, dilakukan pengukuran glukosa darahnya (posttest). Hasil penelitian menunjukkan bahwa ekstrak etanol dosis 750 mg/kgBB, ekstrak etil asetat (dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB) dan ekstrak aquadest (dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB) memiliki kemampuan menurunkan kadar glukosa darah dan hanya etil asetat dosis 750 mg/kgBB, aquadest dosis 500 mg/kgBB dan 750 mg/kgBB yang mampu menurunkan kadar glukosa darah hampir menyerupai kontrol positif (acarbose). Dari hasil uji fitokimia didapatkan adanya alkaloid dan flavonoid di dalam ekstrak etanol, etil asetat dan aquades, dan tannin hanya terdapat dalam ekstrak etanol dan etil asetat.
PENGARUH WAKTU PERENDAMAN PLAT RESIN AKRILIK DALAM PERASAN MURNI BAWANG PUTIH TERHADAP JUMLAH KOLONI CANDIDA ALBICANS
Authors: Natasya Christine , Miftahullaila Mourent , Sinamo Sopan , Nurul Nurul , Griselda Janice
Published: October 2020

Gigi tiruan lepasan yang kotor dapat menjadi tempat melekatnya mikroorganisme. Jika tidak dilakukan pembersihan rutin, maka akan dapat menimbulkan penyakit seperti denture stomatitis yang disebabkan oleh jamur Candida albicans. Perasan murni bawang putih diketahui memiliki kandungan allicin yang dapat menghambat pertumbuhan Candida albicans. Hal tersebut membuat peneliti ingin mengetahui pengaruh lama perendaman bahan basis gigi tiruan akrilik dalam perasan murni bawang putih 50% terhadap jumlah koloni Candida albicans. Jenis penelitian ini merupakan penelitian laboratorium eksperimen dengan rancangan control group post test only. Kelompok sampel terdiri dari dua, kelompok perlakuan direndam dalam perasan murni bawang putih 50% dan kelompok kontrol direndam dalam aquades steril. Setiap kelompok dibagi berdasarkan lama waktu perendaman. Uji analisis yang digunakan ialah uji t test dan dilanjutkan dengan LSD. Hasil penelitian ini diperoleh rata-rata koloni Candida albicans setelah perendaman dalam perasan murni bawang putih 2 jam, 4 jam, 6 jam, dan 8 jam adalah 23,50±9,290; 18,83±1,941; 17,17±1,329 dan 10,33±1,211. Semakin lama waktu perendaman semakin sedikit jumlah koloni Candida albicans pada plat resin akrilik.
Ефективність комплексної програми фізичної реабілітації хворих на бронхіальну астму в поєднанні з патологією гепатобіліарної системи
Authors: Клапчук В. , Марюхніч Н. , Фоменко Т.
Published: October 2020

Мета. Науково обґрунтувати, розробити і визначити ефективність комплексноїпрограми фізичної реабілітації хворих на бронхіальну астму в поєднанні з патологієюгепатобіліарної системи.Методи. Розрахунок індексу Робінсона (подвійного добутку) для оцінки обмінно-енергетичних процесів в міокарді; розрахунок адаптаційного потенціалу серцево-судинної системи, вегетативного індексу Кердо, експіраторного гіпоксичного індексу, інтенсивності болю за допомогою візуально-аналогової шкали ВАШ та психоемоційного стану за тестом САН. Результати. Обстежено 20 осіб віком від 36 до 60 років (з них 10 жінок і 10 чоловіків) з діагнозом бронхіальна астма і супутніми патологіями гепатобіліарної системи. У реабілітаційному комплексі використано лікувальну гімнастику, яка відрізнялась поєднаннямспеціальних фізичних вправ для бронхіальної астми та патології гепатобіліарної системи,способи вольового керування диханням для профілактики та купірування бронхоспазму,сегментарно-рефлекторний та точковий масаж, фізіотерапію, дієтотерапію. Висновки. Під впливом проведеного курсу фізичної реабілітації у експериментальній групі достовірно покращились показники психологічного тесту САН (з 40,2 ± 1,89 до 49,5 ± 2,01 ум. од.; р < 0,01), за шкалою інтенсивності болю ВАШ (з 60,9 ± 2,12 % до 45,6 ± 2,3 %; p < 0,001), адаптаційного потенціалу серцево-судинної системи (з 3,2 ± 0,16 до 2,8 ± 0,14 балів; p < 0,05), а також індексу Робінсона (з 101,4 ± 3,4 до 93,2 ± 2,46 ум. од.; p < 0,05) та експіраторного гіпоксичного індексу (з 3,42 ± 0,17 до 2,60 ± 014 ум. од.; р < 0,01). Досліджені показники функціональних резервів організму хворих на бронхіальну астму, яка поєднується з патологією гепатобіліарної системи, у основній групі кращі, ніж у контрольній. В основній групібуло виявлено більш суттєвий реабілітаційний єфект, що доказує ефективність та перевагирозробленої реабілітаційної програми і дозволяє рекомендувати її до впровадження.
Проблема реабілітації осіб із сенсомоторною афазією внаслідок гострого порушення мозкового кровообігу з позиції фізичного терапевта
Authors: Сибірякін Я. , Балаж М.
Published: October 2020

Мета. Розглянути проблему реабілітації осіб із сенсомоторою афазією внаслідок гострого порушення мозкового кровообігу з позиції фізичного терапевта. Методи. Теоретичний аналіз і узагальнення сучасних науково-методичних літературних даних про реабілітацію осіб із сенсомоторною афазією. Висновки. Наявність сенсомоторної афазії визначає прогноз щодо функціонального відновлення хворого після мозкового інсульту та суттєво впливає на тактику і стратегію ведення пацієнта. На сьогодні основним доведеним підходом в реабілітації таких пацієнтів залишається терапія мови та мовлення (логотерапія). Робіт, які б надавали обґрунтування саме особливостям фізичної терапії пацієнтів із сенсомоторною афазією внаслідок мозкового інсульту у доступній літературі не виявлено, проте наявні попередні дослідження, які свідчать про перспективність розвідок у напрямку виявлення найбільш ефективних стратегій застосування заходів фізичної терапії у пацієнтів із афазією.
Психофізіологічна характеристика стану спортсменів-гандболістів з різним рівнем мотивації до спортивного результату
Authors: Федорчук С. , Іваскевич Д. , Борисова О. , Когут І. , Маринич В. , Тукаєв С. , Петрушевський Є.
Published: October 2020

Мотивація досягнення є одним з основних чинників успішності змагальної діяльності,мобілізації спортсмена до щоденних багаторічних фізичних і психічних навантажень. Одним зметодів прогнозування надійності та успішності спортивної діяльності є моніторинг функціона-льного стану центральної нервової системи спортсменів у взаємозв'язку з їх індивідуально-ти-пологічними характеристиками.Мета. Оцінити психофізіологічні показники спортсменів-гандболістів з різним рівнем мотива-ції до досягнення успіху та уникнення невдач. Методи. У дослідженні брали участь 18 спорт-сменів-гандболістів (КМС) віком 16–17 років. Для визначення психофізіологічних властивостейнервової системи спортсменів використовували діагностичний комплекс «Діагност-1». Длявизначення рівня мотивації у спортсменів були використані тести: «Методика діагностикимотивації до досягнення успіху Т. Елерса» і «Методика діагностики мотиваційної спрямованостіособистості на уникнення невдач Т. Елерса».Результати. Серед обстежених виявлено 83,3 % спортсменів з помірно високим і дуже ви-соким рівнем мотивації досягнення успіху і 16,7 % – з середнім рівнем мотивації досягненняуспіху. Виявлено 22,2 % спортсменів з високим і дуже високим рівнем мотивації уникненняневдач, 55,6 % спортсменів – із середнім рівнем мотивації уникнення невдач, 22,2 % спорт-сменів – з низькою мотивацією уникнення невдач. Більш високий рівень мотивації досягненняуспіху відповідав більш високому рівню сили нервових процесів, працездатності головногомозку (в режимі нав’язаного ритму) і більш високій точності в реакції на рухомий об єкт (мен-шому сумарному запізнюванню за результатами кращої спроби). Рівень мотивації уникненняневдач у обстежених спортсменів асоціювався з моторним компонентом реакції вибору одно-го сигналу з трьох: чим вище був у спортсменів рівень захисту, тим більшою виявилася швид-кість реакції вибору. Виявлені взаємозв’язки мотивації досягнення успіху і уникнення невдачз психофізіологічними характеристиками спортсменів можуть мати прогностичну цінність івикористовуватися для оптимізації спортивного вдосконалення молоді в даному виді спорту.
Study of the effects of the principle of low-volume infusion therapy
Authors: Baydamirova A. , Maharrambayli I.
Published: October 2020

Objective. To study the effects of low-volume infusion therapy on the pathogenetic elimination of endogenous intoxication in a patient with coronary heart disease.

Materials and methods. The study included 30 patients diagnosed with COVID-19. The age of the patients was 45-65 years. All patients underwent generally accepted clinical laboratory and instrumental examinations. Rheosorbilact 200 ml intravenous was prescribed to all patients for the purpose of low-volume infusion therapy to reduce metabolic disorders, reduce the amount of free radicals and weaken inflammatory reactions, eliminate endogenous intoxication. The drug contains potassium chloride, calcium contains magnesium chloride, sodium lactate, sodium chloride and sorbitol.

Results and discussion. The drug was positively received by patients during treatment and no side effects were observed. A “mild” effect on the pH of the blood was observed during the determination of Rheosorbilact. In addition, lactate has been shown to have a positive effect on cardiac function, liver and kidney detoxification function. The positive effect of Rheosorbilact on the functional state of the endothelial layer of microvascular vessels should be noted. As is known, the endothelial layer, which determines the motility of the vascular wall, has anti-inflammatory, antiplatelet, antiproliferative activity. Therefore, improvement of endothelial function under the influence of Rheosorbilact has been observed to increase the stability of hemovascular homeostasis and to maintain a stable level of adequate tissue perfusion in the examined patients. The unconditional advantage of the drug is the improvement of hemorrhagic parameters, as well as prophylactic antithrombotic effect. In elderly patients with ischemic heart disease, a 30 % decrease in platelet aggregation activity was observed during the administration of Rheosorbilact in combination with drugs for complex treatment. One of the positive effects of the drug was the improvement of rheological properties and microcirculation of the blood. In particular, a decrease in blood viscosity from 1.35±0.02 to 1.25±0.03 and a 25 % decrease in the erythrocyte aggregation index were observed in elderly patients.

Conclusions. Thus, according to the results of the presented study, Rheosorbilact can be prescribed for the treatment of endogenous intoxication for small-volume infusion in patients with COVID-19 diagnosed with cardiovascular diseases. A positive effect on the size was observed.
Application of sorbitol-based infusion preparation for normalization of biochemical indicators in the blood in surgery patients with direct rectal cancer
Authors: Varivoda Ye.S. , Orishchin I.Ya. , Lutsiv V.M. , Varivoda V.Ye. , Dzis B.R. , Chaban V.Ye. , Dzis R.P. , Karpovich Ye.Р.
Published: October 2020

Objective. To study the effect of intravenous infusions of the complex drug Rheosorbilaсt polyfunctional action on the biochemical parameters in the blood in operated patients with rectal cancer after anterior resection of the rectum in the early postoperative period.

Materials and methods. The study of biochemical parameters in the blood of 30 patients with colorectal cancer was performed in the first days after surgery, and on the 2nd, 3rd, 5th day after administration of the drug Rheosorbilact. The drug was administered intravenously at a rate of 40 drops per minute. The daily dose of Rheosorbilact was 800.0 ml.

Results. As a result of biochemical studies in patients with colorectal cancer, in the first days after anterior resection of the rectum revealed a decrease in total protein, increased concentrations of urea, creatinine and blood glucose. To correct the biochemical parameters in the blood of such patients immediately after surgery was administered intravenous infusion of Rheosorbilact. After repeated intravenous infusions of Rheosorbilact for 5 days, a significant increase in total protein content, a significant decrease in the concentration of urea, creatinine and blood glucose in the operated patients was found. Therefore, multiple intravenous infusions of the complex drug Rheosorbilact multifunctional action lead to the normalization of biochemical parameters in the blood.

Conclusions. In patients with rectal cancer after anterior resection of the rectum in the first days after surgery revealed a decrease in total protein, increased concentrations of urea, creatinine and blood glucose. Repeated intravenous infusions of the complex drug Rheosorbilact multifunctional action normalize the biochemical parameters in the blood in operated patients with rectal cancer after anterior resection of the rectum in the early postoperative period. Rheosorbilact infusion is recommended for widespread medical use in such patients, especially in the early postoperative period.
Evaluation of complex treatment of patients with postoperative hypothyroidism and non-alcoholic fatty liver disease
Authors: Gavrylenko V.E.
Published: October 2020

Objective. To evaluate the effectiveness of comprehensive treatment of patients with postoperative hypothyroidism (PH) and non-alcoholic fatty liver disease (NAFLD).

Materials and methods. 40 patients (20 men and 20 women) aged 42±6 years with PH and NAFLD were examined. Patients were divided into two groups: main (n=20) and control (n=20). Prior to the study and after 1 month, the level of total cholesterol (TH), triglycerides (TG), low-density lipoprotein (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST) was determined. Patients in both groups were prescribed levothyroxine sodium (125-175 μg a day). Additionally, the 1st group of patients received arginine hydrochloride 42 mg/ml according to the scheme 200 ml a day per 15 days, the next 15 days L-arginine aspartate 200 mg/ml 5 ml a day. And the control group received only levothyroxine sodium.

Results. The level of TH in 1st group decreased from 7.1±0.8 to 6.7±0.4 mmol/l, and in 2nd – from 7.2±0.7 to 6.97±0.35 mmol/l. In the 1st group TG decreased from 3.9±0.4 to 3.5±0.3 mmol/l, and in the 2nd – from 3.8±0.5 to 3.7±0.1 mmol/l. LDL in 1st group decreased from 5.9±1.4 to 5.5±1.2 mmol/l, in the 2nd – from 5.8±1.3 to 5.7±1.4 mmol/l. The level of ALT in 1st group decreased from 47.5±1.82 to 40.1±1.73 IU/l, the level of AST – from 41.3±1.52 to 39.8±1.33 IU/l, in no changes in AST and ALT levels were observed in the control group.

Conclusions. Comprehensive treatment of patients with PH and NAFLD contributed to the improvement of liver transaminases (reduction of AST, ALT), as well as the normalization of the lipid profile (reduction of TC, TG and LDL).
Possibilities of the correction of placental dysfunction in women with preeclampsia
Authors: Karimov A.Kh. , Davletova D.M.
Published: October 2020

Objective. To study the possibilities of diagnosing placental dysfunction and its correction in women with preeclampsia.

Materials and methods. 72 women with preeclampsia in the 2nd and 3rd trimesters of pregnancy were examined at the multidisciplinary clinic of the Tashkent Medical Academy from 2017 to 2019. All women underwent: clinical, laboratory, echography, color Doppler mapping of the vessels of the uteroplacental-fetal system with Doppler analysis of blood flow velocity.

Results and discussion. Diagnostic criteria for placental dysfunction: the placenta acquires its echographic picture at the beginning of the 2nd trimester of pregnancy. During the 2nd and 3rd trimesters of pregnancy, the thickness of the placenta corresponds to 2-3.6 cm. A decrease of <2 cm is regarded as hypoplasia, an increase >4 cm as hyperplasia. Premature aging of the placenta was detected in 77.3 % of cases, the presence of cysts of the placental tissue – in 4.5 %, turbid amniotic fluid – 59.09 %, oligohydramnios – in 27.3 %. At 24th week, the fetal thigh length lag was less by 9.04 % (p<0.05). Doppler criteria for placental dysfunction: in almost equal proportions there are circulatory disorders in the uteroplacental and fetal-placental blood flow (28.2 and 27.7 %). Treatment of placental dysfunction in compensated form: was carried out according to the generally accepted method according to the national guidelines; 4.2 g of L-arginine (Tivortin, “Yuria-Pharm”, Ukraine) was added to the complex therapy in the hospital in dosage 100 ml per day for 7 days. Then Tivortin aspartate was continued on an outpatient basis, orally, 20 ml (1 table spoon 4 times per day, 20 days). The effectiveness of therapy was monitored again after 2 weeks.

Conclusions. Timely initiation of therapy for uterine-fetal-placental blood flow disorders in the 2nd trimester was more effective than in the 3rd.
Fluid resuscitation patients with burn sepsis
Authors: Kovalenko O.M. , Osadcha O.I. , Kovalenko A.A. , Grisha A.S. , Lynnyk O.M. , Belinska N.G.
Published: October 2020

Objective. The purpose the of the study is to improve the fluid therapy regimens for burn sepsis patient.

Materials and methods. The study is based on the observation 52 patients with burn sepsis aged 23 to 65 years, with a total body surface area more than 35 % at the Kyiv City Clinical Hospital № 2 during 2016-2019. Patients were divided into two groups: the main group – 30 patients were treated with crystalloids, plasma, albumin and Rheosorbilact (RSL); control group – 16 patients received treatment without using of RSL. Clinical and biochemical parameters of endogenous intoxication (tissue destruction products, medium weight molecules (MWM), concentrations of lipid oxidation products (LOP) – by diene conjugate content and oxidatively modified proteins (OMP) – by carbonyl groups) were studied.

Results and discussion. Syndrome of endogenous intoxication was an increase in burn sepsis patients, which correlated with an increase in the number of LOP, OMP, MWM, namely an increase in the hydrophobic (most toxic) fraction of MWM, which is 2-3 times higher than in healthy, sick and both groups. MWM and hydrophobic fraction remained high during the observation period in patients of the comparison group. MWM decreased by 1.35 times in patients of the main group relative to the group of crystalloids. The level of carbonyl groups of serum OMP in patients of the comparison group was 50 % higher than in the main group. The indicators of LOP exceeded 1.45 times in the comparison group, which testified to the continuation of oxidative stress and the continuation of systemic inflammation. Acute respiratory distress syndrome (ARDS) was characterized by the appearance of bilateral infiltrates in the lungs, according to radiography. This common organ dysfunction was detected in 75 % of patients in the comparison group and in 63 % of patients in the RSL-group. The duration of mechanical ventilation in the main group decreased by 1,6 days.

Conclusions. The use of Rheosorbylact for patients with burn sepsis at a dose of 15 ml/kg has led to a decrease in the manifestations of intoxication syndrome, reduction of MWM, LOP, OMP, clinical manifestations of systemic inflammatory response, septic complications by 1.3 times, septic shock from 16 to 12 %, and the incidence of ARDS from 75 to 63 %.
Application of the “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III
Authors: Petrushenko V.V. , Grebeniuk D.I. , Skupyi O.M. , Lonskyi K.L. , Stoika R.I.
Published: October 2020

Objective. To evaluate the effectiveness of the “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III.

Materials and methods. 45 patients with a confirmed diagnosis of peripheral arterial occlusive disease of the lower extremities and chronic arterial insufficiency IIb-III were included in the study. All patients were randomly divided into two groups. Patients from experimental group received “Trio” pharmacotherapy (multicomponent isoosmolar solution containing petoxifyllin; multicomponent hyperosmolar solution containing sodium lactate; L-arginine hydrochloridum solution). Patients from comparison group received medical therapy with multicomponent hyperosmolar solution containing sodium lactate and L-arginine hydrochloridum solution.

Results and discussion. The duration of hospital stay was significantly shorter (p<0.01) in the experimental group (7.9±0.97 days) than in the comparison group (9.8±1.63 days). After treatment painless walking distance and peripheral oxygen saturation were significantly greater (p<0.01) in the experimental group (126.25±72.16 m and 90.65±5.07 %) than in the comparison group (54.20±33.59 m and 79.48±6.91 %). At the same time, and intensity of pain was significantly lower (p<0.01) in the experimental group (3.25±1.68 points) than in the comparison group (4,80±1.53 points). The values of the ankle-brachial pressure index were not differing (p<0.05) in both groups (0.49±0.16 and 0.51±0.17 for the experimental group and comparison group, respectively).

Conclusions. “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III allows to improve the basic indicators of the functional state of the microvasculature of the lower extremities.
Analysis of age and associated pathology in patients with hip artoprosthesics
Authors: Svirgun M.V. , Semenenko A.I.
Published: October 2020

Objective. To analyze the presence of concomitant pathology in patients of different age categories who underwent hip arthroplasty by different methods.

Materials and methods. The study retrospectively analyzed 555 case histories of patients (282 men and 273 women) for the presence of concomitant pathology in different age groups (from 20 to 95 years). The age category was determined according to the 2015 World Health Organization age classification. Statistical processing was performed according to StatPlus programs, the differences were considered significant at p<0,05.

Results and discussion. By age, patients were distributed as follows: juvenile (up to 25 years) – 2 patients (percentage of the total was 0,36 %); young (from 25 to 44 years) – 36 patients (6,49 %); middle-aged (from 45 to 59 years) – 132 patients (23,78 %); elderly (from 60 to 74 years) – 236 patients (42,52 %); senile (from 75 to 90 years) – 145 patients (26,13 %) and long-lived (over 90 years) – 4 patients (0,72 %). The average age of patients was 65.18±0.55 (M±m). Concomitant pathology was diagnosed in 484 patients (87,22 %). Depending on the existing concomitant pathology, patients were distributed as follows: no concomitant pathology – 71 patients (percentage of the total was 12,79 %); with hypertension – 38 patients (6.85 %); with diabetes – 11 patients (1.98 %); with coronary heart disease (CHD) – 104 patients (18,74 %); CHD + hypertension – 316 patients (56,94 %); with myocardial infarction – 3 patients (0,54 %); with a stroke – 2 patients (0,36 %); patients with encephalopathy of various genesis – 2 patients (0,36 %); with respiratory pathology – 3 patients (0,54 %); patients with systemic connective tissue diseases – 5 patients (0,90 %). Studies to date have shown a significant increase in comorbidities associated with the age of patients. One of the important predictors and unmodified risk factors for postoperative complications is the age of patients. The influence of age on the result of hip arthroplasty can be explained by a number of factors: the formation of endothelial dysfunction with impaired blood flow, changes in the blood coagulation system and more.

Conclusions. With the development of medical practice, the average life expectancy of the population increases, the methods of arthroplasty and the anesthesiological support of operations are improved, the duration of surgical interventions is reduced. These factors contribute to the steady increase in the number of total joint arthroplasty, in the average age of patients undergoing arthroplasty and, accordingly, in the total comorbid load. That is why stratification of the degree of operative risk continues to be one of the most pressing problems in orthopedic patients.
Transfusion therapy optimization at an acute obstetric blood loss
Authors: Sedinkin V.A.
Published: October 2020

Objective. To define the role of the cryoprecipitate (CP) and prothrombin complex concentrate (PCC) in the acute obstetric blood loss treatment via the assessment of the water sectors’ state, hemostasis, and frequency and severity of clinical manifestations of the multiple organ dysfunction syndrome (MODS).

Materials and methods. 140 women had been examined (over the years 2006-2018), whose child delivery or early postnatal period (fourth stage of labor) had got complicated by an acute severe blood loss with a circulating blood volume deficit of 40 to 60 %. Based on the intensive treatment (IT) characteristics, the patients had been divided into three groups. In the group 1 (post-hoc analysis, n=50), a normal acute blood loss intensive treatment as per the relevant clinical protocols of the Health Ministry of Ukraine had been being provided. In the group 2 (n=44), an acute blood loss intensive treatment as per the abovementioned clinical protocols of the Health Ministry of Ukraine with use of the CP as the first-line drug had been being provided. In the group 3 (n=46), the PCC (Octaplex 20 IU/kg) had been added within the treatment. Thereat, there had been assessed such criteria as follows: RBC count, Hb, Ht, prothrombin index (PI), activated partial thromboplastin time, fibrinogen; the water sectors of the human body had been assessed noninvasively, via the integral impedance method; as well as the clinical signs of the MODS.

Results and discussion. The use of the CP as the first-line drug at a dose of 8 to 10 units had enabled to get decreased the total volume of the infusion and transfusion media by 13.7 % (p<0.05), and the total volume of the administered fresh frozen plazma (FFP) – by 12 % (p<0.05) respectively. The adding of the PCC to the relevant IT guidelines had been resulting in a reduction of the total volume of the infusion and transfusion media by 24.5 % (p<0.01), of the administered plasma volume – by 22 % (p<0.01), and of the corpuscular volume – by 9.1 % (p<0.05) respectively. Furthermore, a decrease in the vasopressor support rate (by 5.1 times, p<0.01) and in the vasopressor support duration (by 1.5 natural days, p<0.01), as well as in the adaptive lung ventilation rate and duration (by 5.7 times, p<0.01), had been being observed; thereat, the number of the patients needing the use of the diuretics had been being reduced (by 2.9 times, p<0.01), as well as the duration of their administration (by 1.7 natural days, p<0.01 respectively). The PI and fibrinogen rate had been corresponding to the norms by the end of the 1st natural day of treatment.

Conclusions. The use of the CP as the first-line drug in the IT of an acute obstetric blood loss ensures a verifiable lessening of need for the infusion and transfusion media. The PCC as the first-line drug prevents the development and progress of the coagulopathy at the treatment of an acute obstetric blood loss, what decreases the frequency and severity of clinical manifestations of the MODS credibly.
Personification of infusion therapy in patients with ischemic stroke depending on the severity of the violation of energy-structural status
Authors: Serikov K.V. , Shifrin G.A. , Smyrnova L.M.
Published: October 2020

Objective. To determine the tactics of infusion therapy in patients with ischemic stroke (IS) depending on the severity of the violation of energy-structural status (ESST).

Materials and methods. A study of 32 patients with severe IS on the National Institutes of Health Stroke Scale (16,7±1,5), who were in the department of anesthesiology with intensive therapy units of the Municipal Non-Profit Enterprise «City Hospital № 9» Zaporizhzhia City Council. Of these, 11 were men (34,4 %; the average age – 68,2±2,5 years), 21 were women (65,6 %; average age – 72,1±1,6).

Results and discussion. In patients with IS, disorders ESST were defined as hyperergic damage at values of cardiac index (CI) of 4,45-5,09 L×min-1×m-2 and oxygen consumption index (IVO2) 186-210 ml×min-1×m-2, and at values of CI ≥5,10 L×min-1×m-2 and IVO2 ≥211 ml×min-1×m-2 – as hyperergic insufficiency. While hypoergic damage ESST occurred at values of CI 2,33-1,82 L×min-1×m-2 and IVO2 104-85 ml×min-1×m-2, and at CI ≤1,81 L×min-1×m-2 and IVO2 ≤84 ml×min-1×m-2 hypoergic insufficiency of ESST was observed. The daily fluid requirement of a patient with IS was calculated according to the formula 4+2+1: for the first 10 kg of weight – 4 ml×kg-1×h-1; from 11 to 20 kg – 2 ml×kg-1×h-1; from 21 kg – on 1 ml×kg-1×h-1 (Park G.R., Roe P.G., 2005; Netyazhenko V.Z., Halushko O.A., 2012).

Infusion therapy in patients with IS and hyperergic damage ESST was performed with 0,9 % sodium chloride solution according to the formula 4+2+1 on the background of the use of esmolol intravenously bolus 250 mg and subsequent administration of 50 mсg×kg-1×min-1, and in hyperergic insufficiency 500 mg of esmolol intravenously bolus and subsequent administration of 100 mсg×kg-1×min-1. While in hypoergic damage ESST on the background of infusion therapy used dopamine or dobutamine 1-5 mсg×kg-1×min-1, and in hypoergic insufficiency, the dose of dopamine or dobutamine was increased to achieve the desired effect.

Conclusions. The personification of infusion therapy depending on the severity of the violation of ESST can improve the results of treatment of patients with IS in the most acute period.
Treatment of bleeding in a patient with immune coagulopathy (acquired haemophilia A)
Authors: Stasyshyn O.V. , Krasivska V.V.
Published: October 2020

Objective. We are representing the case of acquired haemophilia A and analyze the timeliness and adequacy of treatment.

Materials and methods. The subject of the study was immune coagulopathy with a factor VIII (FVIII) inhibitor – acquired haemophilia A.

Results and discussion. Female, 33 years old, pregnancy II, urgent delivery. There was excessive bleeding in the early postpartum period, hemostatic therapy was provided. She hospitalized three times with recurrences of uterine bleeding. Vacuum aspiration of the walls of the uterine cavity was performed twice. After the third recurrence, blood loss of 1200 ml and ineffectiveness of conservative treatment, laparotomy and extirpation of the uterus was performed. Despite intensive care, the bleeding continued, the patient was transferred to the regional clinical hospital, where she was diagnosed with DIC syndrome, stage III, severe anemia. Three relaparotomies were performed, the source of bleeding was not found, there was excessive bleeding from the operating field. The total blood loss was 24,447 ml. Intensive infusion-transfusion therapy was continued, which gave unstable hemostasis. The patient received 12,060 ml of fresh-frozen plasma (FFP), 15,130 ml of erythrocytes, 600 ml of albumin 10 %, 20 doses of cryoprecipitate (CP), 16,000 U of activated prothrombin complex (APCC), 8 mg of recombinant activated factor VII (rVIIa), 8,000 U of prothrombin complex (PC). 16.1 BU/ml of inhibitor FVIII, FVIII <1.0 %, activated partial thromboplastin time (APTT) – 146.1 s was detected on day 37. Within 30 days, blood loss was 10,608 ml; patient received 23,420 ml of FFP, 2,080 ml of erythrocytes, 17 mg of rVIIa, 19,000 U of APCC, 6000 U of PC, 61 dose of CP, 50,000 IU of FVIII. Immunosuppressive therapy (prednisolone 1-1.5 mg/kg/day) was started on day 67 and lasted for 12 months. Bleeding stopped completely 10 months after delivery, and after 14 months the inhibitor was not detected, factor levels and APTT returned to normal. Scheduled reconstructive surgery on the urinary tract was performed without the use of transfusion replacement therapy.

Conclusions. Recurrent postpartum hemorrhage requires early diagnosis of coagulation factors inhibitors, which will ensure specific transfusion and immunosuppressive therapy, avoidance of serious consequences, including extirpation of the uterus and reduce the economic costs of treatment.
The effectiveness of combined pulse therapy in patients with rheumatoid arthritis
Authors: Shukurova S.M.
Published: October 2020

Objective. To study the efficacy of the tolerance of combined regimens of the therapy with high doses of methylprednisolone and methotrexate of the patients with rheumatoid arthritis (RA).

Materials and methods. The study included 85 patients with RA who underwent inpatient treatment in the Rheumatologic Department of the Clinical Hospital of Dushanbe city for the period 2018-2019. From them, women – 83.2 %, men – 26.8 %; the average duration of the disease is 7.4 years. Extra-articular manifestations of RA were determined in 74.3 % of patients. Against the background of the standard therapy, a regimen of bolus pulse therapy (methylprednisolone 500-1000 mg and methotrexate) was taken for 3 days, which has been followed for observation for a year. The effectiveness of the treatment was assessed according to the American College of Rheumatology (ACR) 20/50/70 criteria. The number of the swollen joints and painful joints (NPV), ESR, C-reactive protein level, and the overall disease activity were determined.

Results and discussion. After 1 month of therapy, significant positive dynamics were recorded in the all estimated parameters of the RA activity. There was a significant decrease in NPV, as well as the intensity of pain according to the visual analogue scale. During 3 months of observation, 78 % of the observed patients showed improvement and only 11 % of patients had side effects and have not been required of the discontinuation of the treatment.

Conclusions. The combined pulse therapy of methylprednisolone and methotrexate was an effective and well-tolerated for systemic manifestations of RA and contributed to a significant decrease in RA activity in the shortest time.
Efficiency of nitrate oxide donor Tivortin in women with post-infarction cardiosclerosis in the perimenopausal period with heart failure
Authors: Rofieva H.Sh.
Published: October 2020

Objective. To study the effectiveness of the effect of L-arginine in women in the perimenopausal period with post-infarction cardiosclerosis with manifestations of heart failure.

Materials and methods. The study included 135 women who were hospitalized at the age from 45 to 60 years. All patients were divided into two groups: group I consisted of 80 women (mean age ‒ 45.1±6.6 years) in the perimenopausal period; group II included 55 women (mean age ‒ 60.6±4.6 years) in the postmenopausal period. The functional state of the heart was investigated by the echo-Doppler method. Treatment and observation continued for 3 months. To identify the effectiveness of the therapy was assessed by monthly echo-Doppler sonography. The first group, against the background of basic therapy (nitrates, β-blockers, antiplatelet agents, statins), additionally received the drug L-arginine 4.2 % (Tivortin) solution of 100 ml intravenously drip for 7-8 days, followed by 5 ml (1 g) 3 times per day inside within 3 months. The second group received only the main therapy without the use of L-arginine.

Results. When conducting a comparative assessment of the structural and functional indicators of the heart in women of the first group, it showed that against the background of the main therapy when receiving the drug L-arginine 4.2 % solution 100 ml intravenously before and after treatment were as follows: left atrium size ‒ 5.13±0.18 up to, 4.61±0.14 after; the size of the right ventricle ‒ 3.11±0.01 up to, 2.90±0.08 after; thickness of the interventricular septum ‒ 1.42±0.05 up to, 1.34±0.04 after; posterior wall thickness of left ventricle ‒ 1.38±0.04 up to, 1.34±0.04 after; index of left ventricle myocardial mass ‒ 127.0±5.4 up to, 112.0±4.7 after; end diastolic volume ‒ 144±0.80 up to, 122.0±6.4 after; minute volume ‒ 4.36±0.20 up to, 5.30±0.20 after; ejection fraction ‒ 48 % up to, 52 % after; stroke volume ‒ 54 ml up to, 62 ml after. Clinically noted an increase in exercise tolerance, a decrease in the frequency of nitrate intake and an improvement in the quality of life.

Conclusions. In women of group 1, against the background of basic therapy with the addition of L-arginine 4.2 %, the functional class of heart failure decreases from II to I, the indicators of diastolic filling of the left ventricle are normalized, and the incidence of repeated myocardial infarction decreases.
PROBLEMS OF TRANSPORT FORMATION AND PEDESTRIAN INFRASTRUCTURE OF A LARGEST CITY IN THE XXI CENTURY
Authors: Votinov M.
Published: October 2020

The article describes the features of the study of transport infrastructure, which is due to the transformation of socio-economic conditions that cause a change in the role and place of man in the modern world, diversify and lead to a rapid change in his needs in the material and spatial environment. All this determines the need to recon-sider the existing approaches to the architectural and spatial organization of the city environment. The formation of the architectural environment taking into account the different needs of different social groups became the main in architectural and urban planning. However, so far, unfortunately, very little attention is paid to the humanistic and artistic aspects of the formation of the material and spatial environment of modern man, containing the transport and pedestrian infrastructure of the city. Although these objects and problems of formation of the archi-tectural environment the citizen faces daily. New and rather complex problems caused by the action of scientific and technological progress and the development of motorization of the population, which can be formulated as «transport and city», «car and city», «architecture and transport», are becoming more and more important. Rapid spatial growth of cities, a multiple increase in the urban population and the area of built-up areas, extensive de-velopment of suburban areas raise both the problems of organizing transport systems and the problems of parking and storage of individual vehicles. As the territories develop with the help of the city's transport infrastructure, it is becoming increasingly clear that nature's resources are not coping with the extensive use of its lands.
The total number of cars tends to increase significantly. Mass motorization creates a huge number of interre-lated problems: social; economic; environmental; sanitary and hygienic, etc.
Large and largest cities, which were built in the early to mid-twentieth century in anticipation of the devel-opment of mainly public transport to serve passengers, are not designed to increase the growth of the fleet of indi-vidual vehicles. Individual vehicles are increasingly absorbing the open spaces of the city, making it difficult for people to come into contact with the natural environment. Today, cars are stored in the most inappropriate places: on sidewalks, lawns and even on playgrounds.
The population of cities is increasingly feeling the crisis of the architectural environment, covering places for car storage, the inconvenience of using parking lots, the constant conflicts of movable and immovable vehicles. Street injuries are growing. The impact of vehicles, in particular their parking, often leads to the dehumanization of urban spaces, discomfort and the ecological crisis of the urban environment.

Keywords: transport, transport and pedestrian infrastructure, modern city, humanization.
Design Of Web-Based School Library Information System Using YII Framework In SMA Karya Pembangunan Ciwidey
Authors: Pasaribu Johni S , Sunarya Po Abas
Published: October 2020

The rapid development of the computer world that brings every individual or group of people will use information and communication technology in every activity. Likewise in the world of education, including libraries that utilize information and communication technology in managing the process of borrowing and returning library books. The benefits of making a web-based library information system include being able to save time where there is no need for manual recording, making it easier to find book data or library members, making it easier in making book loan reports and other reports and other benefits. The research method used is Research and Development (R&D). The making of software is done by a waterfall model consisting of: (1) needs analysis, (2) design, (3) implementation, and (4) testing. Then UML visual modeling is used which is the standardization of modeling language for object-oriented software development. The expected results of this study produce a web-based library information system using the YII Framework with MVC (Model View Controller) method in SMA Karya Pembangunan Ciwidey that can solve existing problems. The formulation of the problem of this research is how to build a library information system in SMA Karya Pembangunan Ciwidey so that it can present accurate and efficient information. The purpose of this research is to produce a library information system.
Designing Application For Defect Recording and Handover Of Property Based On Mobile Application by Applying SQLite Technology
Authors: Winasis Persis Haryo , Maulana Raga , Susanto Yodi
Published: October 2020

Property development companies that produce housing products, high rise dwellings, and office buildings generally have data on the quality of buildings, one of which is obtained during the defect inspection process between developers and consumers before handing over units. Recording data is generally still done manually using a form on a paper. For these conditions, researchers tried to build an application based on mobile apps to digitally record the defect checklist of the dwelling so that the data collected can be processed for the needs of analysis and development strategies. Difficulties encountered during the unit handover process using digital methods on the newly completed property, one of which is the quality of data and internet signals. Mobile apps certainly require a data signal connection to send data to the server. This Android-based mobile apps will implement SQLite technology which allows the recording of transactions to be done locally first, which can then be synchronized into the database server after getting the required internet data connection. SQLite was chosen because it has a relatively small library code unlike relational DBMS in general. SQLite is also easy to use without complex configurations. With the support of the ease of function of SQLite it also allows applications to be integrated with the property sales application system.