bluuebunny/crossref_metadata_2025 huggingface dataset:
Düşük Etkili Kentleşme (DEK) Uygulamalarının Kentsel Yağmursuyu Drenaj Sistemi Üzerindeki Etkileri
Authors: Hacı Abdülbaki , Gülbaz Sezar , Paşa Yasin
Published: September 2024

İklim değişimi ve kentleşme hızının artmasıyla birlikte verimli su kullanımının önemi giderek artmaktadır. Günümüzde, yağmursuyu hasadı yapılarak yağmursuyunun tekrar kullanılması ve su temini üzerindeki baskının azaltması hedeflemektedir. Ayrıca, su kaynaklarının korunması amacıyla doğa tabanlı çözüm yöntemlerini içeren Düşük Etkili Kentleşme (DEK) uygulamalarının kullanılması büyük öneme sahiptir. DEK, hidrolojik çevrimi korumak, selin ve yayılı kirlilik kaynaklarının olumsuz etkilerini azaltmak için tasarlanmış bir yağmursuyu yönetimi uygulamasıdır. Bu çalışma kapsamında, Çevre Koruma Kuruluşu Yağmursuyu Yönetim Modeli (EPA SWMM) kullanılarak kentleşme baskısı altında olan İstanbul Esenyurt ilçesinde bulunan bir yerleşim alanının hidrolojik ve hidrolik modeli oluşturulmuştur. Daha sonra, farklı DEK uygulamaları modele entegre edilerek bu uygulamaların yüzeysel akışa ve askıda katı madde (AKM) konsantrasyonuna olan etkisi incelenmiştir. Bu kapsamda, 2, 5, 10, 25, 50 ve 100 yıllık tekerrür aralığına sahip yağışlar ile İSKİ’den temin edilen yağmursuyu drenaj planları modelde kullanılmıştır. Çalışma kapsamında, yağmur varili/tankı (YV), yağmur bahçesi (YB) ve geçirimli kaldırım (GK) DEK uygulamaları, oluşturulan hidrolojik-hidrolik modele dahil edilmiştir. Model sonuçları incelendiğinde DEK uygulamalarının pik debiyi ve AKM konsantrasyon değerlerini büyük oranda azalttığı görülmüştür. Yapılan simülasyonlar sonucunda DEK uygulamalarının 2, 5, 10, 25, 50, 100 tekerrür aralıklı yağışların oluşturduğu akışın pik değerini sırasıyla, %9.89, %10.46, %9.43, %9.14, %9.34 ve %9.02 ve askıda katı madde maksimum konsantrasyon değerlerini %3.85, %3.25, %3.17, %4.80, %4.64 ve %4.75 oranlarında düşürdüğü gözlemlenmiştir.
Évolution technologique et conformité fiscale : l’expérience du Rwanda
Authors: Hakizimana Naphtal , Santoro Fabrizio
Published: September 2024

Les données sur les transactions économiques sont essentielles pour que les administrations fiscales soient en mesure de faire respecter la législation fiscale, et la technologie peut jouer un rôle clé dans l’obtention de l’information. Au cours de la dernière décennie, les administrations fiscales africaines ont de plus en plus adopté des avancées technologiques telles que les systèmes intégrés, la déclaration électronique et les logiciels de facturation électronique (EBM). Ces logiciels permettent aux contribuables de numériser leurs transactions et de transférer automatiquement les informations de facturation à l’administration fiscale. Grâce à leur potentiel élevé, les entreprises peuvent réduire leurs coûts administratifs et de conformité, rationaliser les transactions, améliorer la tenue des registres, renforcer leur capacité administrative et, dans le cas des petites entreprises, améliorer leur capacité à attirer des clients et à se lancer dans des activités commerciales grâce à une précision accrue et à une plus grande transparence. Résumé du document no. 30 sur l’administration fiscale en Afrique.
A ARTE COMO ESTRATÉGIA PARA ESTIMULAR O DESENVOLVIMENTO DA AUTONOMIA E DO SENSO CRÍTICO NA UNIVERSIDADE
Authors: Frota Menezes Lucia Nayara , Sousa Ferreira Gomes Rita Helena
Published: September 2024

A ARTE COMO FERRAMENTA PARA DESENVOLVER A AUTONOMIA E O SENSO CRÍTICO NA UNIVERSIDADE 
Resumo: Parte-se da ideia de que a arte pode ser utilizada no desenvolvimento da autonomia e do senso crítico do estudante universitário. Trata-se de uma pesquisa bibliográfica articulando educadores como: Paulo Freire, Susan O’Neill e Augusto Boal com o contexto da arte na educação das universidades. No levantamento realizado pouco se evidenciou a utilização da arte na educação, principalmente quando se pensa no ensino superior. A pesquisa também serviu como base para produção de um fanzine que trouxe um compilado de sugestões de atividades artísticas possíveis para auxiliar no processo de ensino nas universidades.
TEORIAS EDUCACIONAIS SUBSIDIADORAS E SUBSIDIÁRIAS AO COMPUTER SUPPORTED COLLABORATIVE LEARNING
Authors: Licks Missel Machado Luís Antônio , Soares Fabrício , Dos Santos Nunes Miriam , Da Silva Patrícia Fernanda , Rockenbach Tarouco Liane Margarida
Published: September 2024

O presente artigo visa identificar como a teoria da aprendizagem colaborativa apoiada por computador (CSCL) é fundamentada pela teoria construtivista de Jean Piaget e sócio-construtivista de Lev Vygotsky, além de sua relação com outras contribuições teóricas. Essas teorias salientam a importância da interação social no processo de aprendizagem. Para tanto, compreender as inter-relações dessas teorias é fundamental para que os professores da educação básica e ensino superior possam criar e incorporar atividades construtivistas às suas estratégias de ensino, integrando o uso de recursos computacionais para promover a aprendizagem colaborativa entre os alunos, de maneira a atingir os domínios cognitivos superiores da taxonomia de Bloom na implementação da CSCL. Por fim, o artigo  aborda o potencial de aplicação da CSCL com o metaverso, um ambiente virtual de aprendizado, destacando experimentos onde os alunos podem  interagir colaborando, criando e aprendendo.
DIÁRIO 1973 - 1983
Authors: Fampa Gabriel
Published: September 2024

O artigo propõe uma investigação de Diário 1973 - 1983, diário fílmico do cineasta David Perlov, compreendendo o cotidiano como exílio idealizado pelo autor. Nessa perspectiva, que se apoia na análise crítica das noções de arquivo e de cotidiano, percebe-se a câmera e a fabricação da imagem como meios que procuram isolar o presente de significações contextuais e implicações traumáticas do passado de Perlov. Entende-se que à câmera de Perlov é dado o papel de tanto concretizar quanto impedir exílio idealizado pelo autor em Diário 1973 - 1983.
Yaşlı Bireylerde Hafif Kognitif Bozuklukta Albümin ve Globulin Etkisi
Authors: Keskin Demircan Sultan , Aytar Zeynep Ece
Published: September 2024

Hafif kognitif bozukluğun başladığı dönemdeki değiştirilebilir faktörlerin bilinmesi ve erken fark edilmesi, tedavisi kısıtlı olan demansın önlenebilmesi için önemlidir. İnflamasyon ve demans arasındaki ilişki bilindiğinden, çalışmamızda albümin (A) ve globulin (G) düzeylerinin hafif kognitif bozukluğa etkisini göstermeyi amaçladık. Çalışmaya geriatri polikliniğine unutkanlık şikâyeti ile başvuran 60 yaş ve üstü hastalardan demans tanısı almayan hastalar alındı. Malignite, romatolojik hastalıklar ve aktif enfeksiyonu olan hastalar çalışma dışı bırakıldı. Mini Mental Durum Değerlendirmesinden (MMSE) 24-27 arası almış ve klinik demans skoru (CDR) skoru 0.5 olan hastalar hafif kognitif bozukluk, 28-30 arası alan ve CDR skoru 0 olanlar kontrol grubunu oluşturdu. Yesavage geriatrik depresyon skalası ile depresyon varlığına, geriatrik nütrisyon indeksi ile malnütrisyon riskine karar verildi. Hastaların yaş ortalaması 69.15±5.59 ve % 63.6 si kadın hastaydı. Hastaların 59.9 % unda hafif kognitif bozukluk, %77.9 u eğitimsiz ve % 55.9’u obezdi. Hafif kognitif bozukluk olan grupta anlamlı olarak kadın prevalansı, obezite ve eğitimsizlik daha fazlaydı (p=0.004, p=0.016, p <0.001). Hafif kognitif bozukluk olan grup ile sağlam grup arasında albümin, globulin, A/G, ürik asit, vitamin B12, vitamin 25(OH)D3 vitamini düzeyleri arsındaki fark anlamsızdı (p=0.687, p=0.517, p=0.542, p=0.472, p=0.914, p=0.703). Çok yönlü analizlerde de albümin, globulin, A/G ile hafif kognitif bozukluk arasında ilişkili bulunamadı. Tek yönlü analizlerde kadın olmak, obez olmak, eğitimsiz olmak ve GFR, hafif kognitif bozukluk riskini artırmaktaydı (OR:1.78, OR:1.77, OR: 4.62, OR:1.02; p=0.040, p= <0.001, p=0.017, p=0.036, sırasıyla). Hafif kognitif bozukluk, inflamatuar süreç dışında obezite ve eğitimsiz olmak gibi sebeplerden de etkilenmektedir. Albümin, globulin ve A/G düzeylerini etkileyen başka patolojik durumlar da olduğundan hafif kognitif bozukluk için kullanımı uygun değildir.
WITHDRAWN: A Multi-Objective Optimization Model for Energy Allocation and Petroleum Products Distribution in Green Supply Chains (Case Study of IRAN National Petroleum Corporation MIANDOB)
Authors: Attaria Mahdi Yousefi Nejad , Ejlaly Babak , Ghahvechia Fatemeh
Published: September 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
SARS-CoV-2 infection rates and associated risk factors in healthcare settings: systematic review and meta-analysis
Authors: Bansal Amit , Trieu Mai-Chi , Eriksson Emily M , Zhou Fan , McVernon Jodie , Brokstad Karl Albert , Cox Rebecca Jane
Published: September 2024

To protect healthcare workforce during the COVID-19 pandemic, rigorous efforts were made to reduce infection rates among healthcare workers (HCWs), especially prior to vaccine availability. This study aimed to investigate the prevalence of SARS-CoV-2 infections among HCWs and identify potential risk factors associated with transmission. We searched MEDLINE, Embase, and Google Scholar from 1 December 2019 to 5 February 2024. From 498 initial records, 190 articles were reviewed, and 63 studies were eligible. ROBINS-E tool revealed a lower risk of bias in several domains; however, some concerns related to confounding and exposure measurement were identified. Globally, 11% (95% confidence interval (CI): 9-13) of 283,932 HCWs were infected with SARS-CoV-2. Infection rates were associated with a constellation of risk factors and major circulating SARS-CoV-2 variants. Household exposure (odds ratio (OR): 7.07; 95% CI: 3.93-12.73), working as a cleaner (OR: 2.72; 95% CI: 1.39-5.32), occupational exposure (OR:1.79; 95% CI: 1.49-2.14), inadequate training on infection prevention and control (OR: 1.46; 95% CI: 1.14-1.87), inefficient use of personal protective equipment (OR: 1.45; 95% CI: 1.14-1.84), performing aerosol generating procedures (OR: 1.36; 95% CI: 1.21-1.52) and inadequate hand hygiene (OR: 1.17; 95% CI: 0.79-1.73) were associated with an increased SARS-CoV-2 infection. Conversely, history of quarantine (OR: 0.23; 95% CI: 0.08-0.60) and frequent decontamination of high touch areas (OR: 0.52; 95% CI: 0.42-0.64) were protective factors against SARS-CoV-2 infection. This study quantifies the substantial global burden of SARS-CoV-2 infection among HCWs. We underscore the urgent need for effective infection prevention and control measures, particularly addressing factors such as household exposure and occupational practices by HCWs, including cleaning staff.
Characterization of Betalains-Enriched Nutraceutical Tablets from Beta vulgaris L. Pomace Powder
Authors:   Gargi Gargi74 Ghoshal, Kaur Akashdeep
Published: September 2024

The objective of this research was to develop nutraceutical tablets enriched with phytonutrients and antioxidants by dehydrating beetroot pomace, which is abundant in bioactive compounds, and integrating it with pomace extract obtained using ultrasonication. The research involved evaluating the packaging, microstructure, and physical and chemical properties of freeze-dried powder. The freeze-dried powder exhibited favorable flow properties, reduced Hausner ratio, and low hygroscopicity. Analysis confirmed higher phytochemical content, supported by FTIR. SEM and particle size distribution analysis indicated consistent particle generation. The freeze-dried powder was mixed with pomace extract in a 1:1 weight-to-volume ratio to augment phytonutrient levels before compression into tablets. The tablets exhibited rapid disintegration and in vitro release profiles of betalains. Storage at 25 ± 2°C over five months revealed significant humidity and water movement, retaining approximately 81% of phytochemicals and 78% antioxidant activity. This approach not only effectively utilizes beetroot waste but also produces bioavailable nutraceutical tablets, offering significant health benefits.
From survival rates to therapeutic targets: Investigating peroxisome-related genes in head and neck squamous cell carcinoma
Authors: Zhang Wenmin , Wu Si-yuan , Zhang Jing , Wu Zhi-biao , Huang Hong-wei , Lin Xuhong
Published: September 2024

This study focused on Head and Neck Squamous Cell Carcinoma (HNSCC) and recognized peroxisomes as key regulators of tumor progression. The aim was to identify prognostic biomarkers using a peroxisome-related gene model. Various analyses, including differential, univariate, and LASSO Cox regression, were employed to construct and validate the prognostic model using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Diagnostic and prognostic efficacy of peroxisome-related genes were evaluated through T-test and survival analysis. Tumor immune infiltration analysis revealed a correlation between immune cell infiltration score and peroxisome-related model. The peroxisome-related gene prognostic model demonstrated excellent predictive ability for HNSCC patients, with the risk score as an independent prognostic factor. High expression of ABCD2 and ACOX3 emerged as protective prognostic biomarkers, suggesting a favorable impact on patient prognosis, while increased PHYH expression was associated with higher risk, indicating its potential role as an adverse prognostic gene in HNSCC. These model genes showed a positive correlation with six distinct types of immune cells in the TIMER database. In conclusion, the peroxisome-related gene prognostic model effectively predicts HNSCC prognosis, and ABCD2, ACOX3, and PHYH are identified as potential prognostic
Influence of Polypharmacy on Post-surgical Mortality in Elderly Adults With Hip Fracture
Authors: García-Tercero Elisa , Rosique Alejandro Valcuende , Rosique Ana Valcuende , Rubio Daniela Andrea Villalón , Bono Ana Navalón , Cunha-Pérez Cristina , Ribes José Viña , Tarazona-Santabalbina Francisco José
Published: September 2024

Purpose: Polypharmacy is a common problem in surgical patients with hip fractures. Their influence on the mortality is what we pretend to study, aiming to inform management strategies and reduce mortality risks.
Methods: A retrospective study was conducted at Hospital de la Ribera, Alzira, targeting patients aged ≥70 who underwent hip fracture surgery in 2017 and 2018. Data were extracted from electronic medical records, including demographic details, comorbidities, and medication use. Polypharmacy was defined as the use of five or more medications. Mortality rates were analyzed at 30 days, 6 months, 1 year, 2 years, and 5 years post-surgery using Kaplan-Meier survival curves and Cox regression analysis.
Results: Among 644 patients included, (mean age 84.5 years, 70.5%women), polypharmacy was present in 63.8%, and severe polypharmacy (≥10 medications) in 19.1% of patients. Polypharmacy significantly increased mortality at all time intervals: 30 days (10.6% severe polypharmacy vs 3.0% no polypharmacy, p=0.042), 6 months (22.7% vs 9.6%, p=0.003), 1 year (39.4% vs 11.9%, p<0.001), 2 years (51.5% vs 14.8%, p<0.001), and 5 years (76.2% vs 26.3%, p<0.001).It was also associated with higher rates of major complications and red cell transfusions. Hazard ratios for 5-year mortality were significantly elevated for patients on hypotensives, benzodiazepines, antidiabetics, opioids, neuroleptics, and anti-dementia drugs.
Conclusion: Polypharmacy significantly impacts postoperative mortality and morbidity in elderly hip fracture patients. Effective management, including medication review and deprescribing strategies, is crucial to improving outcomes. Comprehensive geriatric assessments and interdisciplinary approaches are recommended to optimize treatment and reduce the adverse effects of polypharmacy.
Identification of key macrophage subtypes and therapeutic targets in periodontitis using integrated bioinformatics analysis and machine learning
Authors: Li Li , He Chengjiang , Dai Fang , Yang Yuting , Long Ting , Yang Kaiqiang , Ai Yufeng , Xu Fancheng , Wu Jianxin , Deng Libin , Song Li
Published: September 2024

The innate immune system is fundamental to the body's primary defence against pathogens and plays a critical role in the pathogenesis of periodontitis (PD). Macrophages, as a key component of this innate response, are instrumental in the disease's development and progression. However, our understanding of the distinct macrophage subtypes implicated in PD and the identification of novel therapeutic targets remains limited. We obtained single-cell RNA sequencing (scRNA-seq) and bulk sequencing data from PD patients from the Gene Expression Omnibus (GEO). By integrating the scRNA-seq data, we have constructed a comprehensive single-cell atlas of the human gingiva. Key macrophage subtypes were screened using gene set variation analysis (GSVA). CellChat was used to assess intercellular communication. Using three machine learning algorithms, four hub genes (FCN1, CD93, XBP1, CTSH) associated with FCN1 + MAC were identified. These results were further validated experimentally. We revealed that macrophage subtypes were closely associated with inflammation and bone destruction in PD patients. Four hub genes that could be used as biomarkers to distinguish PD were identified. Our study found novel disease markers and potential drug targets, providing a foundation for more precise and effective interventions in the management of PD.
Association of changes in the left ventricular ejection fraction with physical function characteristics and survival in patients with heart failure
Authors: Fukuta Yoshitatsu , Tanaka Shinichiro , Kawaguchi Tomonori , Arizono Shinichi , Sawai Shota , Yoshida Akihisa , Tsugita Natsumi , Fuseya Takahiro , Segawa Tomonori
Published: September 2024

Background: The relationship between the degree of change (Δ) in the left ventricular ejection fraction (ΔLVEF) and physical function and survival remains unclear. Therefore, we assessed the associations among physical characteristics, the ΔLVEF, and physical function and survival in response to heart failure (HF) treatment.
Methods: In this retrospective cohort analysis, patients with HF aged ≥65 years who underwent cardiopulmonary exercise testing (CPX) were classified into three groups based on the LVEF (recovered [HFrecEF], worsened [HFworEF], and unchanged [HFuncEF]). CPX measured the peak oxygen uptake (VO2) and peak minute ventilation (VE).
Results: Overall, 191 patients were included. Age, height, and weight did not differ significantly between the groups. The HFworEF group showed significant deterioration in blood urea nitrogen, creatinine, brain natriuretic hormone, and estimated glomerular filtration levels. Oral administration of beta-blockers was significantly higher in the HFrecEF group than in the other groups. Based on the Kruskal–Wallis test, the three groups differed significantly in terms of the peak VO2 (HFrecEF, median 806.5; HFworEF, 600.0; and HFuncEF, 749.0; P<.05), heart rate (HFrecEF, 121.0; HFworEF, 100.0; and HFuncEF, 107.0; P<.05), and VE (HFrecEF, 35.3; HFworEF, 25.8; and HFuncEF, 34.0; P<.01). Furthermore, the peak VO2 (ρ: 0.25) and peak VE (ρ: 0.18) were not correlated with the ΔLVEF (all P<.01). The HFrecEF group had a significantly lower mortality rate at 60 months compared with the HFuncEF group (log-rank test, P<.05).
Conclusions: The HFworEF group had poor heart and kidney function and low physical function. The HFrecEF category had a relatively favourable long-term mortality rate at 60 months. ΔLVEF was not correlated with physical function.
Transforming in-service high school biology teachers’ acceptance of evolution through professional development
Authors: Pérez-Vega Ángel Eduardo , Papa Riccardo , Borrero Michelle
Published: September 2024

Background: Evolution plays a significant role in the understanding of biology. Educators must acknowledge the importance of this theory for effective biology teaching, but there are several educational gaps both in the classroom and in in-service teachers that need to be addressed to help improve the acceptance and understanding of the theory of evolution. In this study, the Measure of Acceptance of the Theory of Evolution (MATE) was translated, adapted, and evidence was gathered for its use with Spanish-speakers, as means to study how in-service teachers’ acceptance of the theory of evolution changes after participating in a professional development program (PD), framed in the genome-to-phenome overarching theme.
Results: Evidence was gathered to evaluate content validity, response process, internal structure, and reliability of the MATE instrument for it use with Spanish speakers (i.e., MATE-E). A pilot test was conducted, enabling an Exploratory Factor Analysis to be performed. Five factors were identified. When administered to teachers that participated in a PD program, descriptive statistics showed that all teachers had higher scores in the posttest. A Wilcoxon matched pairs and signed ranks test produced a Zscore of -2.023 and a p value of .043.
Conclusions: MATE’s translation to Spanish, as well as its adaptation, and the evidence-gathering process for the instrument’s possible use with Spanish-speaking participants are discussed. A PD was implemented to develop concepts related to the theory of evolution for in-service teachers. MATE-E was administered to five teachers before and after participating in the PD program. A Wilcoxon matched pairs and signed ranks test was carried out to test if treatment was effective in changing their acceptance of the theory of evolution. The null hypothesis was rejected; and it can be confirmed that the treatment was both significant and positive in changing participants’ acceptance of the theory of evolution.
The genetic interaction between Atopic dermatitis and Celiac disease: A bidirectional two-sample Mendelian randomization study
Authors: Rong Jian , Chang Peng , Li Yaoyao , Wang Xin , Song Mei
Published: September 2024

Background: Multiple previous observational studies have reported inconsistent results in investigating the association between atopic dermatitis (AD) and celiac disease (CD).Observational studies may be inadequate for elucidating potential causal relationships between AD and CD due to the issues of reverse causation and confounding variables. The existence of a bidirectional causal relationship between AD and CD remains unclear.
Objective: To investigate the potential bidirectional causal relationship between atopic dermatitis and celiac disease.
Methods: Utilizing the summary statistics from large-scale Genome-Wide Association Studies (GWASs) in European populations, we examined the potential bidirectional causal effects between AD and CD through a bidirectional Mendelian randomization analysis. The inverse-variance weighted (IVW) method was employed as the primary analytical approach. The MR-Egger, weighted median, simple mode, and weighted mode were utilized as complementary approaches.
Subsequently, a series of sensitivity analyses were conducted to evaluate the robustness and reliability of the MR findings.
Results: Our findings revealed that the IVW results indicated a significant increase in the prevalence of AD in individuals with genetically predicted CD (OR = 1.46, CI = 1.07-1.96, PIVW = 0.014) and conversely (OR = 1.05, CI = 1.03-1.08, PIVW = 4.80x10-6). Furthermore, subsequent sensitivity analyses addressing heterogeneity, pleiotropy, and other potential biases substantiated these results.
Conclusions: We established a bidirectional causal relationship between atopic dermatitis and celiac disease through a two-sample bidirectional MR study. Therefore, early screening and preventive measures are recommended for patients with atopic dermatitis and celiac disease to mitigate long-term complications and reduce additional burdens.
Are there any differences between women with long term gastric bypasses and non-operated matched controls in body composition, muscular strength and physical performance?
Authors: Sánchez Andrés , Basfi-fer Karen , Inostroza Jorge , Carrasco Gabriela , Sambra Verónica , Codoceo Juana , Rojas Pamela
Published: September 2024

Introduction:
There is concern about an excessive loss of fat-free mass (FFM), and its consequences in the long term after bariatric surgery. The aim of this study was to evaluate body composition, muscle strength and physical performance in a group of women who underwent Roux-en-Y Gastric Bypass (RYGB-G) more than 2 years ago, and had stable weight, not significant weight regain, using micronutrient supplementation and compare them with a non-operated control group (CG).
Methods
We assessed body composition by DEXA, handgrip strength (HGS) and physical performance through sit-to-stand tests in the RYGB-G (n = 13) and in a CG (n = 13) matched by age, body mass index, skin phototype and physical activity level. Dietary intake, sun exposure, nutritional, biochemical and hormonal assessments were done in both groups.
Results
The RYGB-G had a mean follow-up of 6.7 ± 2.8 years and had a greater FFM (42.3 ± 4.9 vs 38.4 ± 4.5kg, p = 0.049), FFM% (60.7 ± 5.1 vs 56.1 ± 5.1%, p = 0.027) and FFM/Fat Mass (1.72 ± 0.43 vs 1.39 ± 0.30kg, p = 0.033) than the CG. The CG had a higher fat mass percentage (FM% 36.4 ± 5.2 vs 41.1 ± 5.3%, p = 0.029). There were no differences between the groups for HGS or physical performance tests. The average energy intake was significantly higher in the CG 1021.5 (957.5-1278.7) vs 1498.6 (1310.7-1767.7) kcal/day p = 0.002.
Conclusion
Women with a long term RYGB (BMI 27.5 ± 3.4 kg/m2) and regular use of micronutrients supplementation had a higher FFM, FFM%, FFM/FM and lower FM% compared to a CG, without differences in HGS or physical performance tests.
Hierarchical methodology framework for assessing dynamic evolution trends and driving mechanisms of water conservation in the Yellow River Basin, China
Authors: Zhao Gaolei , Tian Shimin , Liang Shuai , Jing Yongcai , Chen Rongxu , Wang Wanwan , Han Bing
Published: September 2024

Water conservation (WC) is a critical ecological service function in the Yellow River Basin (YRB). There is currently a lack of detailed exploration of WC development processes and the impact mechanisms of driving factors at spatiotemporal scales in the YRB. By collecting data on DEM, land use, soil, meteorology, reservoirs, and observed discharge, this study established a large-scale WC model using the Soil and Water Assessment Tool (SWAT). The abrupt change test, empirical orthogonal function (EOF), wavelet analysis, hierarchical partitioning analysis (HPA), geodetectors, and aridity index were employed to analyze the multi-spatiotemporal characteristics and driving forces of WC calculated using the water balance method. The results are as follows: (1) The average WC among the YRB was 9.11 mm (74.68 × 108 m3) from 1960 to 2020. Pasture and forests contributed to 48.65% and 22.05% of the average annual WC, respectively. (2) WC exhibited four forms: less/more in the YRB, more in the southeast (northwest), and less in the northwest (southeast). (3) Forests and pastures in land use had higher average WC capacity, while Gansu, Shaanxi, and Qinghai ranked in the top three for average WC among the nine provinces. (4) Precipitation was the major driving force affecting WC variations, with the interaction between precipitation and actual evapotranspiration being the most significant. (5) Drought was a significant cause of negative WC. Protecting and managing crucial WC areas was essential for improving the ecological environment. This research elucidates the driving forces of WC in the YRB, providing scientific support for improving regional WC and promoting sustainable development.
Serum Lactate Dehydrogenase and Gamma-Glutamyl Transferase Correlate Optimally with Nottingham Prognostic Index for Breast Cancer
Authors: Rutenge Sylvery Mwesige , Kyaruzi Victor Meza , Misidai Mungeni , Mchembe Mabula Daud , Mwanga Ally Hamisi
Published: September 2024

Background
LDH and GGT have been identified as prognostic serum markers for breast cancer patients. The serum level of LDH is increased due to increased anaerobic glycolysis in malignant neoplastic conditions. GGT has also been noted to increase in circulation, indicating the extent of oxidative stress within the body. Their levels are high in advanced breast cancer patients. Moreover, in our setting, there are no serum marker data available on a routine basis for breast cancer surveillance among women orfor predicting patient prognosis. Thus, these markers can augment the available tool(s) for predicting breast cancer prognosis since they are widely available, accessible, and economically affordable.
Objective
This study aimed to assess the correlation between LDH/GGT and the NPI among women with breast cancer.
Study Methods
A cross-sectional study was conducted for 12 months. The data were collected by interviewing patients, patients’ files and from the hospital’s electronic database (Jeeva) and then completed the structured checklist. IBM SPSS version 27 was used to analyse the data. The mean, median and standard deviation were used to present numerical variables. Categorical variables are presented as frequencies or proportions. Correlations were assessed and analysed by Spearman correlation coefficient and linear regression models,while receiver operating characteristic (ROC) curves were used to determine the accuracy.
Results
The 104 patients who underwent radical mastectomy for breast cancer had a mean age of 48.51 ±12.80 years. Among them, 27 (26%) were diagnosed before 40 years of age.
With a Spearman coefficient of r=0.66 and p<0.01, a regression coefficientof b=4.21 and p<0.001, and a coefficient of determination of 28.3%, a substantial positive correlation between LDH and the NPI was found. Based on the NPI and TNM, LDH demonstrated significant predictive accuracy for the prognosis of breast cancer patients, with AUCs of 0.85 (95% CI: 0.77 - 0.92, p<0.001) and 0.87 (0.80 - 0.94, p<0.001), respectively, according to the ROC curve.
A weak positive correlation between GGT and the NPI was observed, with a Spearman coefficient of r=0.46 and p<0.01. With AUCs of 0.73 (95% CI: 0.62 ─ 0.83, p<0.001) and 0.76 (95% CI: 0.67 ─ 0.85, p<0.001) for the ROC curve, GGT showed modest predictive accuracy for the prognosis of breast cancer patients based on the NPI and TNM, respectively.
Conclusion
Preoperative serum levels of LDH and GGT can serve as predictors for breast cancer outcome for women with breast cancer undergoing modified radical mastectomy in conjunction with other potential prognostic factors.
The mediating effect of self-efficacy and physical activity with the moderating effect of social support on the relationship between negative body image and depression among Chinese College students: a cross-sectional study
Authors: Yuan Ye , Zheng Junyi , Yang Ke , Su Yuqi , Jin Lei , Mao Huapei , Zhou Qiang , Wu Daili
Published: September 2024

Background
Fitness to maintain an ideal body shape is becoming increasingly popular among college students. However, it also leads to many mental health issues. This study explores the pathways through which negative body image affects depression in college students. It also examines possible means of implementing depression interventions in college populations through the mediating roles of self-efficacy and physical activity, and the moderating role of social support.
Method
The present study employed a convenience sampling method to collect data from 600 university students using the Body Image Scale, Self-Efficacy Scale, Physical Activity Scale, General Social Support Scale and Depression Self-Rating Scale. Data analysis and structural equation modeling were conducted using SPSS, M-plus and R software.
Result
The result indicate that negative body image is positively correlated with depression. Self-efficacy and physical exercise play a chain mediating role between body image and depression. Additionally, social support moderates the effects of self-efficacy by predicting the pathway through which physical activity effects depression.
Conclusion
The study suggest that individuals with a negative body image are more prone to depression and that physical exercise can help alleviate their depressive symptoms. Self-efficacy is an important mediator, and social support moderates adherence to physical exercise. Therefore, attention should be paid to the mental health issues of college students with negative body images.
Suicidality, resilience and burnout in a population of oncology nurses
Authors: Despotović Milena M. , Ristić Dragana Ignjatović , Banković Dragić , Milovanović Dragan , Stepanović Željko , Despotović Mile , Zlatanović Milena , Raketić Diana , Milisavljević Milan , Boljanović Jelena , Ćetković Mila
Published: September 2024

Oncology care gives employees the opportunity to care for people during the most difficult periods of their lives, which can affect the psychological well-being of nurses in different domains. The aim of this work is to examine to which extent resilience and professional burnout influence the occurrence of suicidality in oncology nurses and determine the differences compared to other populations. The study included a total of 75 oncology nurses, as well as three control groups: nurses of various specialities, administrative workers and nursing students. The respondents filled out the Serbian version of the RASS-Suicidality Assessment Scale, the Serbian version of the Brief Resilience Scale-BRS, and the Maslach Inventory for Professional Burnout. The observed variables were compared by Spearman's Rho correlation. In the population of oncology nurses and technicians, resilience and suicidality are negatively correlated with each other (r = -0.375, p = 0.001). In the same population, professional burnout and suicidality are not correlated, but the correlation was significant in all other control groups. Our research established the importance of strengthening the resilience of employees in the health sector, through various programs and trainings. Working professionals are more often forced to develop individual protective strategies and incorporate them into daily practice.
How digital technology affects economic growth through industrial structural change?
Authors: Yang Tilong , Du Changyu
Published: September 2024

This article explores through an empirical study how changes in industrial structure as a result of the development of digital technology can affect economic growth. The study finds that, in general, the development of digital technology has a positive impact on economic growth, but based on the perspective of industrial structure change, the servitization of the industrial structure due to the development of digital technology can inhibit economic growth. Thus, economy factor must be guided to integrate deeply with the real economy, especially the manufacturing industry, and must not be allowed to flow excessively into the service industry.
JEL Codes: L160; O14; O47
Feasibility of Using Ready Mix Concrete Plants Wash Water as Mixing Water in Concrete
Authors: Shamseldein Ayman , Amr Mohamed , Attia Fatma
Published: September 2024

Egypt relies heavily on the Nile River as its main source of drinking water. With Ethiopia's new dam and Egypt's increasing population, researchers anticipate a major water shortage. In response, the Egyptian government has launched several initiatives, such as canal linings and seawater desalination plants, to prevent potential water loss. This research aims to offer a solution by reducing the use of potable water in concrete production, which currently accounts for over 16% of the country's fresh water consumption. The proposed approach involves using recycled wash water from ready-mix plants instead of potable water. At present, these plants use potable water for washing. Each cubic meter of concrete produced requires 70 litres of wash water for the truck mixer and pump. By replacing potable water with recycled wash water, potable water usage could decrease by 30%. Given Egypt's concrete production levels, this could save around 11 million cubic meters of water annually. This saved water could irrigate 70,000 feddans using traditional methods or 420,000 feddans with advanced irrigation techniques. This research explores the feasibility of using wash water in concrete by examining four replacement ratios: 25%, 50%, 75%, and 100%. The findings suggest that while wash water can be used in concrete with an optimal replacement ratio with potable water.
Floristic composition, structure and regeneration status as affected by agro-climatic variation in the Bale mountains national park, South-eastern Ethiopia
Authors: Muhammed Annissa , Elias Eyasu
Published: September 2024

Background
The Bale Mountains National Park (BMNP) is an internationally significant biodiversity hotspot located in the Bale eco-region, southeastern highlands of Ethiopia. Despite its huge ecological importance, habitat degradation occurs at an alarming rate across different agro-climatic zones, posing a severe threat to the survival of many species. This study aims to assess the effects of agro-climatic variation on floristic composition, structure, and explore the human-induced factors responsible for ecosystem changes in the park.
Results
A total of 144 sampling plots covering an area of 5.76 ha were established across three altitudinal gradients with four replications to collect representative vegetation data. Mean species comparison across agro-climatic zones was determined using one-way ANOVA and significant differences were reported with p < 0.05. Results showed that both species richness (76) and mean DBH of woody species (49.63 ± 1.34 cm) were significantly higher in the sub-moist mid highland than in the cold humid afro-alpine zone (29) and in the cool moist mid highlands (31 and 44.50 ± 1.42 cm, respectively). The density of seedlings, saplings, and mature trees was significantly higher in the sub-moist mid highland compared to the cool moist mid highlands.
Conclusion
The study concludes that the sub-moist mid-highland harbors most species and has trees with higher DBH, requiring protection against ecological degradation due to human activities. The higher altitude cold humid afro-alpine zone is ecologically fragile and needs a comprehensive natural resource management strategy that combines restoration and protection of the natural ecosystem.
Sexual health literacy among unmarried men attending premarital counseling center in Ardabil, Iran, 2023
Authors: Rashidi Nima , Mashoufi Mehrnaz , Mardi Afrouz , Shadman Atefeh
Published: September 2024

Background
Sexual health literacy (SHL) is an important predictor of an individual's sexual behavior. However, little is known about this issue among Iranian men. This study aimed to determine sexual health literacy in unmarried men attending the premarital counseling center in Ardabil, Iran, 2023.
Methods
This analytic cross-sectional study was conducted in Ardabil Province between April and October 2023 with unmarried men referred to the only premarriage counseling center. A total of 384 eligible men were included in the study via a simple random sampling method. Data were collected via a demographic questionnaire and a standardized SHELA questionnaire and were analyzed via SPSS software version 27.
Results
Over 50% of the participants had adequate (36%) and excellent (23%) SHL. The results revealed that men’s education level was significantly related to SHL and all of its dimensions (P < 0.05). Additionally, there was a significant correlation between men's occupation and their ability to access SHL (P < 0.05), and urban men had lower levels of SHL than rural men did (P < 0.05).
Conclusions
The findings suggest that more than half of the unmarried men had adequate or excellent SHL. Factors such as education, occupation and place of residence had a significant relationship with SHL. More planning and special attention should be given to this topic.
Pay for performance (P4P) and estrangement: A mixed-method study on the physicians’ perceptions of the influence of a new reimbursement system on themselves as professionals, their moral stances, and their work and private lives
Authors: Kavas Mustafa Volkan , Tut Hasan , Şenyürek Gamze , Elhan Atilla Halil
Published: September 2024

Background
Pay-for-performance system (P4P) has been in operation in the Turkish healthcare sector since 2004. While the government defended that it encouraged healthcare professionals’ job motivation, and improved patient satisfaction by increasing efficiency and service quality, healthcare professionals have emphasized the system’s negative effects on working conditions, physicians’ trustworthiness, and cost-quality outcomes. In this study, we investigated physicians’ accounts of current working conditions, their status as a moral agent, and their professional attitudes in the context of P4P’s perceived effects on their professional, social, private, and future lives.
Methods
First, we held 3 focus groups with 19 residents and 1 specialist regarding their lived experiences under P4P and thematically analyzed the transcripts. Second, we developed a questionnaire to assess how generalizable the qualitative findings are for a broader group of physicians. The tool has three parts questioning 1) demographic information, 2) working conditions, and 3) perceived consequences and effects of P4P. 2136 physicians responded to the survey. After refining the data, we conducted the statistical analysis over 1378 responses by using Spearman's correlation coefficient, exploratory factor analysis (EFA) for categorical data, and Kruskal-Wallis variance analysis.
Results
Thematic analysis revealed two dimensions: 1) factors leading to estrangement, and 2) manifestations of estrangement. As for the initial, participants thought that P4P affected relationships at work; family and social relationships; working conditions; quality of the specialty training; quality of healthcare services; and it caused healthcare system-related consequences. Concerning the latter, the following themes emerged: Estrangement of the physician; damaging effects on physician’s psychology; physician’s perception of their future life; and physician as a moral agent. According to EFA, a 5-factor structure was appropriate: F1) Estrangement; F2) adverse effects on the physician’s quality of life; F3) favorable consequences; F4) physicians becoming disreputable; F5) unfavorable consequences.
Conclusions
The findings suggest that under P4P, physicians have become more estranged towards their profession, their patients, and themselves. They suffer from deteriorating working conditions, lack of motivation, lack of work-related satisfaction, and hopelessness regarding their future. Furthermore, P4P impairs their ability to realize themselves as moral subjects practicing in alignment with professional values and principles.
A timeless gene-regulated pheromone binding protein governs female mating behavior in Bactrocera dorsalis
Authors: Jiao Yuting , Luo Guohong , Lu Yongyue , Cheng Daifeng
Published: September 2024

The rhythmic mating behavior of insects has been extensively documented, yet the regulation of this behavior through sex pheromone sensing olfactory genes controlled by the clock genes in the rhythm pathway remains unclear. In this study, we investigated the impact of circadian rhythm on female recognition of male rectal Bacillus-produced sex pheromone in B. dorsolis. Behavioral and electrophysiological assays revealed a peak in both mating behavior and response to sex pheromones in the evening in females. Comparative transcriptome analysis of female heads demonstrated rhythmic expression of the Timeless gene-Tim and odorant binding protein gene-Pbp5, with highest expression levels occurring in the evening. Protein structural modeling, tissue expression patterns, RNAi treatment, and physiological/behavioral studies supported Pbp5 as a sex pheromone binding protein whose expression is regulated by Tim. Furthermore, manipulation of female circadian rhythm resulted in increased morning mating activity, accompanied by consistent peak expression of Tim and Pbp5 during this time period. These findings provide evidence that insect mating behavior can be modulated by clock genes through their effects on sex pheromone sensing processes. Our results also contribute to a better understanding of the molecular mechanisms underlying rhythmic insect mating behavior.
Colon Cancer Image Enhancement using Grundwald Letnikov Fractional Order Derivative
Authors: Patowary Sudipta , Tuithung Themrichon
Published: September 2024

Fractional calculus, which deals with derivatives and integrals of non-integer order, has gained significant attention over the past decade due to its ability to model complex systems more accurately than traditional integer-order calculus. Many systems in science and engineering exhibit behaviors that cannot be fully described by integer-order derivatives and integrals alone. Fractional-order methods have found significant application in image enhancement, deniosing, texture analysis, image fusion and so on. The first-order (gradient) and second-order (Laplacian) derivatives, are sensitive to abrupt changes in pixel intensities, typically corresponding to edges and corners in images. Fractional-order derivatives can suppress noise more effectively while preserving important image features, leading to smoother and more accurate results in noisy imagesIn this paper, we introduce a novel image processing method utilizing the Grundwald-Letnikov fractional order derivative and applied on EBHI-SEG dataset colon cancer images. This approach effectively suppresses noise and minimizes abrupt changes in pixel intensities, which are typically associated with edges and corners in images. The performance of the proposed method was evaluated using the PSNR (Peak Signal-to-Noise Ratio), NAE (Normalized Absolute Error), and SSIM (Structural Similarity Index) metrics. Our method demonstrated superior accuracy compared to existing techniques.
Properties of promising cartilage implants based on cellulose/polyacrylamide composite hydrogels: results of in vivo tests carried out over a period of 90 – 120 days
Authors: Buyanov Alexander L. , Gofman Iosif V. , Bozhkova Svetlana A. , Saprykina Natalia N. , Netyl’ko Georgii I. , Panarin Evgenii F.
Published: September 2024

High-strength composite hydrogels “cellulose-polyacrylamide” were synthesized by free-radical polymerization of acrylamide conducted inside the previously formed physical network of regenerated plant cellulose. Partial hydrolysis of the amide groups of these hydrogels yielded their ionic forms with a degree of hydrolysis of 0.1 and 0.25. The cylindrical hydrogel samples of three compositions were implanted in the preformed osteochondral defects of the rabbit’s femoral knee joints. No signs of migration or disintegration of the tested implants were revealed in the course of in vivo tests as long as 90 and 120 days after the implantation. The mechanical behavior of hydrogel samples-implants before implantation and after their removal from the joints of laboratory animals was studied in detail. The morphology and chemical composition of the removed implants were studied by SEM combined with the EDX method. The results obtained were shown that the mechanical characteristics of hydrogel implants remained practically unchanged after in vivo tests. The removed implants, as well as the initial hydrogels, endured cyclic compression loading at the amplitude up to 50 %. Compression stresses up to 3 – 10 MPa were recorded in these tests, which is close to the data obtained by several authors for natural articular cartilages in the same conditions of loading. The principal differences in the chemical composition and morphology of the implant area adjacent to the subchondral bone for non-ionic and ionic types of implants have been revealed. For non-ionic implants in this area intensive mineralization with formation of calcium phosphates inside the polymeric hydrogel network is observed, while the border area of ionic implants practically does not undergo mineralization.