bluuebunny/crossref_metadata_2025 huggingface dataset:
A Silver–Russell-szindróma diagnosztikai lépései és terápiás lehetőségei egy családi halmozódást mutató eset kapcsán
Authors: Kovács Árpád Ferenc , Beniczky Nikolett Jusztina , Bertalan Rita Ágnes , Sallai Ágnes
Published: November 2022

A Silver–Russell-szindróma jellegzetes minor anomáliák mellett (relatív
macrocephalia, kiemelkedő homlok, kék sclera, lefelé ívelő szájzug,
micrognathia, alacsonyan ülő fülek, illetve arc-, skeletalis és végtagi
aszimmetria) súlyos, méhen belüli és születést követő növekedési zavarral jár.
Az endokrin rendszert érintő eltérések is kiemelt jelentőségűek. Kialakulásának
molekuláris háttere összetett, de a leggyakrabban a 11-es kromoszóma és/vagy a
7-es kromoszóma Silver–Russell-szindróma szempontjából kritikus régióinak
érintettsége okozza. A molekuláris géndiagnosztika mellett a
Netchine–Harbison-féle klinikai diagnosztikai pontrendszer segíti a diagnózis
felállítását. Bár a tünetegyüttes többnyire sporadikus megjelenésű, rendkívül
ritka familiáris halmozódást bemutató esetünkben a négy testvérből három
gyermeknél Silver–Russell-szindróma került felismerésre. A
Silver–Russell-szindróma korai, lehetőleg már újszülöttkori diagnosztizálása
kulcsfontosságú a megfelelő táplálásvezetés, a korai fejlesztés, majd a
növekedésihormon-kezelés időben történő elkezdése szempontjából. A betegek
gondozása és megfelelő utánkövetése kiemelkedő jelentőségű a szindrómához
társuló potenciális szövődmények időben történő felismerése és megfelelő
kezelése céljából. Orv Hetil. 2022; 163(45): 1775–1781.
Perifériás ideg epineuralis metilénkékfestése kadáverkézen
Authors: Szabó Tamás , Kormos Viktória , Gaszner Balázs , Rékási Zoltán
Published: November 2022

Bevezetés: A parciális aponeurectomia a Dupuytren-kontraktúra
kezelésére leggyakrabban végzett műtéti eljárás. A betegségben kialakuló
patológiás szövet megváltoztathatja a digitális ideg anatómiai elhelyezkedését,
ami megnehezíti az ideg műtét közbeni lokalizációját és dissectióját, és növeli
a iatrogén idegsérülés kockázatát. Intraoperatív idegfestési eljárással az ideg
lokalizációja megkönnyíthető lenne, ezáltal a iatrogén idegsérülés kockázata is
csökkenne. Állatkísérleteinkben korábban igazoltuk, hogy metilénkékoldattal a
perifériás ideg in vivo megfesthető az ideg struktúrájának és
funkciójának károsítása nélkül. Célkitűzés: A patkány nervus
ischiadicus modellen már sikeresen alkalmazott metilénkékoldattal végzett
idegfestési eljárás hatékonyságának vizsgálata humán kadáver digitális idegen.
Módszer: Vizsgálatunk első fázisában formalinnal fixált
kézen négy digitális ideg epineuralis festését végeztük el 40 µl 1 : 80-as
hígítású metilénkékoldattal. A második vizsgálatban fixáción át nem esett
kadáverkézen hat digitális ideg festését végeztük. A megfesthető idegszakasz
hosszának növelésére két ideg festéséhez 200 µl metilénkékoldatot használtunk.
Eredmények: Az epineuralis idegjelölés formalinfixált
idegeken nem működött ideálisan. Friss, formalinos fixáláson át nem esett humán
kadáver digitális idegen az idegfestési eljárást sikeresen alkalmaztuk, a
megfestett idegszakasz tekintetében állatkísérletes eredményeinket reprodukálni
tudtuk. 40 µl 1 : 80-as hígítású metilénkékoldattal átlagosan 13 mm-es, míg 200
µl oldat használatával 18 mm-es idegszakaszt sikerült megfesteni.
Következtetés: Formalinnal fixált digitális ideg festése a
fixáció következtében fellépő szöveti zsugorodás miatt korlátozottan lehetséges.
Formalinos fixáláson át nem esett digitális idegek esetén a megtartott anatómiai
viszonyok mellett 18 mm-es idegszakasz megfesthető. További vizsgálatokat
tervezünk Dupuytren-szövettel és hegszövettel körülvett digitális idegen, a
technika kézsebészeti műtétek során történő alkalmazhatóságának megítélésére.
Orv Hetil. 2022; 163(46): 1834–1839
A kontrasztanyag nélküli mágnesesrezonancia-angiográfia diagnosztikus teljesítménye alsó végtagi verőérbetegekben
Authors: Juhász Georgina , Csőre Judit , Suhai Ferenc Imre , Gyánó Marcell , Pataki Ákos , Vecsey-Nagy Milán , Pál Dániel , Fontanini Daniele Mariastefano , Bérczi Ákos , Csobay-Novák Csaba
Published: November 2022

Bevezetés: Az alsó végtagi verőérbetegség (lower extremity
arterial disease, LEAD) gyakran szövődik krónikus veseelégtelenséggel, így az
érintett betegeknél kiemelten fontos a nephroprotectiv képalkotó eljárások
alkalmazása. Célkitűzés: Célunk a kontrasztanyag nélküli
„quiescent-interval single-shot” mágnesesrezonancia-angiográfia (QISS MRA) és
digitális szubtrakciós angiográfia (DSA) diagnosztikus teljesítményének
összehasonlítása volt. Módszerek: A LEAD-betegeknél az elektív,
diagnosztikai célú DSA napján QISS MRA vizsgálatot is végeztünk. Egy 19
szegmentumból álló modell alapján értékeltük a szűkület mértékét (nincs
szűkület, <50%, 50–70%, >70%) és a képminőséget (5 pontos Likert-skála, 1:
nem diagnosztikus, 5: kiváló képminőség). A QISS MRA diagnosztikus
teljesítményét az obstruktív (>70%) lumenszűkületre vonatkoztatva határoztuk
meg, a DSA-t tekintve referenciastandardként. A szűkületek megítélhetőségének
interobszerver reprodukálhatóságát az ’intraclass’ korrelációs koefficiens (ICC)
kiszámításával osztályoztuk. Eredmények: 34 betegnél 623
szegmentumot értékeltünk a fenti szempontok szerint (10 nő, átlagéletkor: 67 ± 9
év). A QISS MRA minden régióban legalább a DSA-val megegyező, jó képminőséget
eredményezett (minden régió: 4 [4–5] vs. 4 [3–5];
aortoiliacalis: 4 [4–4] vs. 4 [4–5]; femoropoplitealis: 4 [4–4]
vs. 4 [4–5]; tibioperonealis: 4 [4–5] vs.
3,5 [3–4]; minden esetben p≤0,01). A QISS MRA értékelhetősége az összes régióban
felülmúlta a DSA-t (99,0% vs. 96,1%, p<0,001). A
diagnosztikusan értékelhetetlen szegmentumok száma négyszer több volt a DSA
esetében, mint a QISS MRA-nál (n = 24 vs. n = 6). A QISS MRA
diagnosztikus pontossága 91,3%, szenzitivitása 84,8%, specificitása 93,0%,
pozitív prediktív értéke 76,3%, negatív prediktív értéke 95,8% volt. A szűkület
mértékének interobszerver variabilitása az összes régióra vonatkoztatva 0,94
volt a QISS MRA és 0,88 a DSA esetében. Következtetés: A QISS
MRA megbízható alternatívának bizonyult a DSA-val összehasonlítva az alsó
végtagi verőérbetegség diagnosztikájában. Orv Hetil. 2022; 163(45):
1782–1788.
Ki adná a veséjét, és ki nem?
Authors: Chrisztó Zita , Urbán Róbert , Rigó Adrien
Published: November 2022

Bevezetés:Napjainkban az élő donorral történő szervtranszplantáció egyre gyakrabban végzett egészségügyi beavatkozás. Az élő szervdonáció az egészségügyi kérdéseken túl számos pszichoszociális kérdést felvet az adományozókkal és motivációjukkal kapcsolatban.Célkitűzés:Az élő vesedonációhoz fűződő attitűd, ismeretek, hiedelmek feltárása és az élődonációs hajlandóságot meghatározó főbb tényezők – mint érintettség, személyiségvonások, egyéni értékrend, jóllét és életcél – feltárása.Módszer:Keresztmetszeti vizsgálatban 571 felnőtt, magyar, önkéntes résztvevő töltötte ki az online kérdőívcsomagot, amely attitűdre, hiedelmekre és ismeretekre vonatkozó kérdéseket tartalmazott, a Schwartz Értékrend Kérdőívet, a Nagy Ötök személyiségtesztet, a WHO-5 Jóllét kérdőívet és az Életcél kérdőívet.Eredmények:A válaszadók többsége családtagnak és barátoknak adományozná életében egyik veséjét, a legkevesebben nem adományoznának egyáltalán, míg a válaszadók 16,8%-a akár ismeretlennek is hajlandó lenne. A résztvevők többsége tudta (71,8%), hogy a vese a leggyakrabban átültetett szerv, valamint hogy élő donorból is e szervet transzplantálják a leggyakrabban. Szignifikáns, de gyenge összefüggést találtunk az élődonációs szándék tekintetében az érintettséggel (r = 0,187), az egyéni értékrenddel (Én-átalakulás) (r = 0,208) és a transzplantációról való ismeretszinttel (r = 0,104). Szignifikáns összefüggés volt az ismeretek (r = –0,352) és a donorokkal kapcsolatos hiedelmek között (r = 0,136). Többszörös lineáris regresszióelemzés alapján az élődonációs szándékot szignifikánsan magyarázta az értékrend (Én-átalakulás) (β =0,218) és az a negatív hiedelem a donorokkal kapcsolatban, hogy az élődonációt követően rosszabb egészségügyi állapotba kerülnek (β =–0,207).Megbeszélés:Az élő szervadományozáshoz való hozzáállás összefüggésben áll a hiedelmekkel, melyek az egyén ismereteitől függenek, az ismereteket pedig befolyásolja az érintettség. A hozzáállás továbbá összefüggésben áll az egyén mások iránti jóindulatával és felelősségérzetével.Következtetés:Az élő szervadományozásról való ismeretek és az egyéni értékrend tényezői, mint jóindulat és szociális felelősségérzet, központi szerepet játszanak az egyén hozzáállásának alakulásában. Orv Hetil. 2022; 163(45): 1798–1805.
Tápcsatornai endoszkópos eljárásokkal összefüggő infekciós kockázat a SARS-CoV-2-járvány idején.
Authors: Fábián Anna , Bor Renáta , Tóth Tibor , Bacsur Péter , Bálint Anita , Farkas Klaudia , Milassin Ágnes , Molnár Tamás , Resál Tamás , Rutka Mariann , Gelley András , Gyökeres Tibor , Hagymási Krisztina , Kovalcsik Zsolt , Kristóf Tünde , Lombay Béla , Lovik Kálmán , Miheller Pál , Rácz István , Salló Zoltán , Tomcsik Zoltán , Varga Márta , Vincze Áron , Szepes Zoltán
Published: November 2022

Bevezetés: A COVID–19-pandémia jelentősen befolyásolta az
endoszkópos laboratóriumok működését. Az endoszkópos vizsgálatok nagy
vírusátviteli rizikójúnak számítanak. Célkitűzés: A
koronavírus-járványnak a magyarországi endoszkópos laborok működésére kifejtett
hatásának és az endoszkópos személyzet SARS-CoV-2-fertőzésben való
érintettségének felmérése a 2020-as évben. Módszerek: Országos
szintű, keresztmetszeti, kérdőíves tanulmányunk során magyarországi endoszkópos
laboratóriumok vezetőit kerestük meg online formában. Vizsgáltuk a 2020-ban
elvégzett felső és alsó tápcsatornai endoszkópiák számát a 2019-es
referenciaévhez viszonyítva (átlag [95%-os konfidenciaintervallum]), továbbá a
SARS-CoV-2-fertőzéssel érintett dolgozók számát és fertőződésük potenciális
forrását. Eredmények: A megkeresett intézmények 30%-ából
érkeztek válaszok (33/111). A referenciaévhez képest sem a felső (1593
[743–1514] vs. 1129 [1020–2166], p = 0,053), sem az alsó
tápcsatornai endoszkópos vizsgálatok száma (1181 [823–1538] vs.
871 [591–1150], p = 0,072) nem csökkent, bár a vírushullámoknak megfelelően
mindkét vizsgálattípus esetén 80%-ot meghaladó vizsgálatszám-csökkenést
tapasztaltunk. Dedikáltan fertőző betegek vizsgálatára kialakított helyiség az
intézetek 12%-ában állt rendelkezésre. A védőfelszerelések az első és a második
hullám alatt 70%-ban, illetve 82%-ban voltak mennyiségileg és minőségileg
megfelelőek. A vizsgálat előtt fertőzöttségirizikó-stratifikáció az intézetek
85%-ában, míg PCR-vizsgálat csupán 42%-ukban történt minden esetben. Az első és
második járványhullám alatt a dolgozói létszám az orvosoknál 33%-kal, illetve
26%-kal, az asszisztenseknél 19%-kal, illetve 21%-kal csökkent, elsősorban
életkori korlátozás, COVID-ellátásba való áthelyezés miatt. Az asszisztensek
32%-a, az orvosok 41%-a esett át COVID-fertőzésen, 16%-ban, illetve 18%-ban nem
megfelelő védőfelszerelés-használattal összefüggésben.
Következtetés: A járványhullámok alatti restrikciók
feloldását követően a vizsgálati terhelés emelkedik. A SARS-CoV-2-vakcinák
elérhetősége előtt az endoszkópos laborok dolgozóit érintő COVID-fertőzések
15%-a nem megfelelő védőfelszerelés-használattal volt összefüggésbe hozható. Orv
Hetil. 2022; 163(46): 1814–1822.
Sharing Lessons Learned
Authors: Rónay Johnston Emily , Solomon Amorao Amanda , Kim Jonathan
Published: November 2022

This article draws on our workshop presented at the 2021 Watson Conference that showcased the lessons we have learned about antiracist programming from piloting a Certificate in Antiracist Writing Pedagogy and launching the Inaugural Learning/Teaching for Justice Conference at our home insti­tution, the University of California, San Diego. Taken together, these two initiatives have taught us that antiracist work in high­er education necessitates three guiding values: intersectional collaboration, collective accountability, and radical care. In this article, we ground these values in scholarship and analyze the contradictory institutional context from which these values have emerged, namely from within a first-year writing program that expects students to become proficient in academic writing through the counterhegemonic study of social hierarchies and mass movements for justice. We explore the specific work we have done to navigate this contradiction so as to imagine and conspire with our audience towards substantive transformation within higher education. The article takes the form of a gather­ing of reflections from different stakeholders holding different positionalities within our program but who each have used in­tersectional collaboration, collective accountability, and radical care to guide their antiracist work. Specifically, the reflections represent those of the two presenters at the Watson Conference and those of a former student of theirs who was hired to coor­dinate the inaugural Learning/Teaching for Justice Conference. Regardless of our differing positionalities in the institution, we all three share an ethic of antiracist resistance and hope our experiences are useful as you engage in your own projects in the name of justice.
Social Justice Conference Planning for Writing Studies
Authors: Byrd Antonio , Novotny Maria , Pemberton Michael , Young Vershawn Ashanti
Published: November 2022

In this series of personal reflections, authors from the Social Justice at the Convention Committee and the Local Arrangements Committee discuss their efforts to do social justice conference planning for the Conference on College Composition and Communication from 2018 to 2021. The challenges of doing social justice programming in a shifting convention landscape have been tremendous but, the authors have found, they are not insurmountable. The authors use their experiences to offer a conceptual framework and guiding questions for enacting social justice events at academic con­ventions. The lessons the authors have learned in the process about funding, labor, sustainability, and ethics of incorporating community voices will be important and useful to readers who want to highlight such programming in national, regional, local, and online venues.
Does French have theme vowels?
Authors: Pomino Natascha , Remberger Eva-Maria
Published: November 2022

Most Romance languages have reduced the Latin conjugation classes (CCs) maintaining only three main classes which are marked as general rule by different theme vowels (ThVs). The development in French, however, is different and has led to less transparent verbal forms and to a CC system that is not describable, at first glance, in terms of ThVs. In our contribution, we pursue the following questions: Does French have ThVs? And if so, which form do the French theme “vowels” – or maybe better, theme extensions – have? Can French verbs be segmented in more than two constituents? Based on a critical discussion of psycholinguistic evidence and embedded in the framework of Distributed Morphology, we show that, in French, regular verbs, verbs with morphophonologically predictable allomorphy and even idiosyncratic verbs are decomposed for lexical access. We argue for two thematic CCs (with the ThV [-ə-] for the 1st CC of the type aimer and [-is-] for the CC of the type finir), while the remaining CCs are athematic. Certain types of root allomorphy, e.g. the (non)appearance of root final consonants, depend, in essence, on whether or not there is a ThV-position available. We propose a feature hierarchy for French CCs, which additionally mirrors the fact that even athematic CCs can have ThVs in certain neutralization contexts, where the realization of the ThV is taken over from the CC of the type finir.
Avaliações socioeconômicas e ambientais de propriedades agrícolas e entendimento ambiental de produtores rurais no Município de Floreal - SP
Authors: Delmilho Gustavo , Sergio Luis de Carvalho  , Miguel Spolon Fávaro
Published: November 2022

The term sustainability is in global evidence. It is an inescapable topic when discussing agribusiness, productivity, preservation of fauna, flora, climate, use of natural resources, waste disposal, among others. However, ways to improve this scenario are shown through the use of environmental education and community awareness. This work, in particular, aimed to evaluate the social, economic and environmental aspects of rural properties in the Municipality of Floreal - SP, as well as the perception of farmers. Questionnaires were applied to 40 producers containing 26 questions with different answers, addressing environmental issues and how they are treated. Factors such as: family composition, forms of work performed, and use of technologies were evaluated. Agricultural production was also estimated, in addition to factors resulting from these activities, such as production technologies, machinery used, soil conservation and riparian forests. From the answers, problems were revealed, as an example: lack of environmental perception, in addition to little relevance on the part of producers in this context. Another issue of paramount importance is the consequences, such as contamination of the environment, misuse of water resources present, among others. In the end, there was a lack of environmental education programs that would provide rural producers with a balanced view of managing their activity, without neglecting the safety of their own health and the environment in which they live.
Roadmap to the study of gene and protein phylogeny and evolution - a practical guide v2
Authors: not provided florian.jacques
Published: November 2022

Developments in sequencing technologies and the sequencing of an ever-increasing number of genomes have revolutionisedstudies into biodiversity and organismal evolution. This accumulation of data has been paralleled by the creation of numerous public biological databases through which the scientific community can mine the sequences and annotations of genomes, transcriptomes, and proteomes of multiple species. However, to find the appropriate databases and bioinformatic tools for respective inquiries and aims can be challenging. Here, we present a compilation of DNA and protein databases, as well as bioinformatic tools for phylogenetic reconstruction and a wide range of studies on molecular evolution. We provide a protocol for information extraction from biological databases and simple phylogenetic reconstruction using probabilistic and distance methods, facilitating the study of biodiversity and evolution at the molecular level for the broad scientific community.
LIMITES E POSSIBILIDADES PARA A IMPLANTAÇÃO DO IMPOSTO SOBRE GRANDES FORTUNAS NO BRASIL
Authors: Lima Nayara Rodrigues , Gonçalves Jonas Rodrigo , Costa Danilo da
Published: November 2022

O tema deste artigo é a implantação do Imposto sobre Grandes Fortunas no Brasil. Investigou-se o seguinte problema: “Quais são as vantagens e as desvantagens da implantação do Imposto sobre Grandes Fortunas no Brasil?”. Cogitou-se a seguinte hipótese “a efetivação desse imposto pode gerar dificuldades e malefícios à ordem economia-tributária brasileira”. O objetivo geral é discutir os limites e as possiblidades para a implantação do Imposto sobre Grandes Fortunas no Brasil. Os objetivos específicos são: apresentar todo o processo de tentativa de efetivar tal tributo desde a Constituição de 1988, descrever seus possíveis efeitos sobre o desenvolvimento econômico do país e situá-lo no contexto da Reforma Tributária. Este trabalho é importante para um operador do Direito devido a ser um tema constantemente debatido e pela sua complexidade; para a ciência, é relevante por apresentar o processo legal que envolve o tema agrega à sociedade pelo fato de se tratar de um tributo que afeta a sociedade. Trata-se de uma pesquisa qualitativa teórica com duração de seis meses.
O DIREITO DE IMAGEM EM TEMPOS VIRTUAIS
Authors: Novak Luiz Roberto , Ferreira de Souza Oshima Elaine Beatriz , Alexandre Fernandes Leonardo
Published: November 2022

Os desenvolvimentos tecnológicos nos últimos dois séculos, acompanhados pelo crescimento dos meios de comunicação de massa e da propaganda, chamaram a atenção da comunidade jurídica para o estudo das imagens. Originalmente, esse bem jurídico era usado para proteger outros direitos, como o direito à honra, à privacidade, aos direitos autorais e ao direito ao próprio corpo. Ao longo do tempo, viu-se que se trata de um bem jurídico autônomo e digno de proteção própria, mas há penalidades por lacunas na proteção da personalidade. O direito de imagem elevou a um direito fundamental autônomo, parte de uma lista de termos rígidos e rápidos essenciais à dignidade humana. A Constituição Federal também prevê novos significados de imagem – além da constituição física do indivíduo – que afirmam os atributos que uma pessoa apresenta à sociedade. Portanto, nos dias atuais cabe a indenização por dano moral quando o direito de imagem é violado, o que pode ocorrer por mera violação do direito ao retrato, independentemente de dano à honra ou outros direitos, conferindo proteção efetiva a autonomia do bem fundamental da personalidade.
Yabancılaşma Ve Dindarlık Üzerine Bir Araştırma
Authors: KAFALI Hasan , KAZAK Mehmet
Published: November 2022

Bu çalışmanın konusunu yabancılaşma ile sosyodemografik değişkenler arasındaki ilişkilerin tespit edilmesi ve yabancılaşma düzeyi ile dindarlık (dini tutum ve içsel dini motivasyon) arasındaki ilişkinin araştırılması oluşturmaktadır. Modern hayatın sonuçlarından olan yabancılaşma olgusunun alt boyutlarıyla bilimsel yöntemlerle araştırılması ve dindarlığın yabancılaşma üzerindeki etkisinin ortaya çıkarılması ve anlamlandırılması, sosyodemografik değişkenlerle yabancılaşma ve dindarlık arasındaki ilişkiler ve bunların etki düzeylerinin tespit edilmesi amaçlanmıştır. Nicel araştırma yöntemlerinden ilişkisel (korelasyonel) tarama modeline göre tasarlanan araştırmanın çalışma grubu 149’u erkek ve 155’i kadın üzere online platformlardan ve sosyal medyadan ulaşılmış 304 kişiden oluşmaktadır. Araştırmada, “Demografik Bilgi Anketi” ile birlikte, “Sosyal Yabancılaşma Ölçeği”, “Dini Tutum Ölçeği” “İçsel Dini Motivasyon Ölçeği” kullanılmıştır. Sosyodemografik değişkenlerden medeni durum, yaş, cinsiyet ve ekonomik değişkenlerin yabancılaşma üzerinde etkili oldukları sonucuna ulaşılmıştır. Yabancılaşmanın ve dindarlığın alt boyutları ile yapılan çalışmada, içsel dini motivasyonla yabancılaşma arasında istatistiksel olarak anlamlı negatif ilişki tespit edilmiştir. İçsel dini motivasyon arttıkça yabancılaşma azalmaktadır.
Modificación de los Procesos Cognitivos mediante Conflictos Estructurales con Aplicativos de Gamificación Formal
Authors: Diaz-Riva Meliza , Fernandez-Chaucayanqui Sol , Holguin-Alvarez Jhon
Published: November 2022

La gamificación desde el uso de plataformas en entornos virtuales, ha servido para diversos estudios con hallazgos en el aprendizaje estructural. Sin embargo, existen pocas evidencias en el uso de plataformas de gamificación formal que incluyan el conflicto cognitivo desde su utilidad pedagógica. Se ha realizado la investigación aplicando un diseño experimental con medidas pretest y postest. Aplicamos dos tipos de conflictividad cognitiva a los que denominamos Paquetes de gamificación y Paquetes cognitivos. Utilizamos gamificadores formales (Mural.ly, Mentimeter, Google Jamboard, Kahoot!), aplicados en tres grupos de comparación experimental de 150 estudiantes (M = 13,2 años; SD = 2,03). Se evaluaron tareas de lectura, matemática, razonamiento y ciencias de la investigación. Los hallazgos reportaron mayores efectos en el grupo que recibieron los Paquetes de gamificación, en segundo lugar se visualizaron los efectos de estrategias Paquetes cognitivos, debido a que estos fueron más lentos en la provocación de mejor rendimiento en el aprendizaje.
Formación Interdisciplinar-Humana para Estudiantes de Pregrado e integrantes de La Fundación Federico Arango
Authors: Gallego Monsalve Carlos Alberto , Grajales Carvajal Yeidy Luveny , Jiménez García Estefanía , Duque Castaño María Camila , Rios Yepes José Fernando
Published: November 2022

El objetivo de este texto es socializar brevemente la experiencia significativa Formación Interdisciplinar – Humana para Estudiantes de Pregrado e Integrantes de La Fundación Federico Arango, ejercicio desarrollado con El Semillero Cultivo de Vida perteneciente a la Facultad de Teología y Humanidades en la Línea de Religión y Cultura. Este objetivo se articula a la propuesta formativa de La Universidad Católica de Oriente que centra sus procesos de formación en “el servicio a la persona humana y a la comunidad” (Plan de Desarrollo UCO 2018…). Ejercicio que se hace evidente en formar a sus estudiantes en sus disciplinas, con la transversalidad del humanismo, fortaleciendo así el saber – saber, saber - hacer y el saber – ser. Humanismos que se fundamentan en el pensamiento de Monseñor Alfonso Uribe Jaramillo, quien plantea un hacer lo axiológico en una praxis desde la perspectiva humana cristiana. Es así como, nace el Proyecto Formación Interdisciplinar – Humana para Estudiantes de Pregrado e Integrantes de La Fundación Federico Arango, desde el entorno universitario, con sus discusiones académicas, desarrollando la propuesta práctica en un contexto social determinado. Trabajo que, desde la axiología se convierte en praxis con la metodología de Investigación Acción, generando en los estudiantes de la Universidad espacios académicos formativos que se comparten con los integrantes de la Fundación, con el propósito de llevar a ellos, un incentivo de por qué y para qué retomar procesos de cambio.
Evaluation, complications and treatment of chronic rhinosinusitis
Authors: Khatab Omar Ali , Bajaber Moataz Ali , Alharbi Nada Talal , Alharbi Naif Talal , Alshahrani Nada Aouda , Fageeh Nariman Ayman , Salman Ahmed Zuhair , Omran Samar Mohammed Al , Alshahrani Amal Faleh , Mira Abdulgader Jamal , Marouf Faris Ayman
Published: November 2022

Chronic rhinosinusitis (CRS) is a disease which commonly affects people of all ages and significantly impacts the quality of life. The clinical symptoms of CRS, which is defined by a chronic inflammation of the sinonasal mucosa, include persistent rhinorrhoea, nasal congestion, sinus pressure, and a diminished sense of smell that lasts longer than 12 weeks. CRS can be categorized into two groups: CRS with nasal polyps and CRS without nasal polyps. Inflammatory, environmental, and host factors are responsible for causing CRS although the mechanism is debatable. Diagnostic examination including anterior rhinoscopy, endoscopy or radiography, ideally from sinus computed tomography, can aid in confirmational diagnosis of CRS. The objective of the treatment is to improve mucociliary clearance, nasal drainage and outflow, reduce local infection and inflammation, and facilitate topical medicament access. Nasal saline irrigation and intranasal corticosteroid sprays are the first-line treatments. Antibiotics may be helpful for patients who have symptoms of a superimposed, acute active sinus infection. Endoscopic sinus surgery may be useful if medical therapy is ineffective. Referrals to otolaryngologists should be made for patients who are not responding to first-line medical therapy. CRS if not treated timely can further lead to complications including development of various diseases such as asthma breathing issues, smell disorders and certain bacterial and fungal infections. Effective treatment of the CRS is hence needed. The purpose of this research is to review the available information about evaluation, complications and treatment of CRS.
Scientific Integrity-Overcoming Challenges in Medical Research and Publication
Authors: Mahendra Jaideep
Published: November 2022

No Abstract.
Tirzepatide: Revolutionary Drug in Management of “Diabesity”
Authors: Chouhan Vansh , Spal Simran , Kumar Rakesh
Published: November 2022

Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist has recently been approved by FDA for type 2 diabetes in adults as a single dose weekly. Tirzepatide is in phase 3 development for adults with obesity or overweight with weight-related comorbidity. Tirzepatide is also under evaluation for treatment of non-alcoholic steatohepatitis, heart faialure and obstructive sleep apnea.
The War on Drugs: A Global Perspective
Authors: Sidhu Gulbahar Singh
Published: November 2022

No Abstract.
In planta colonisation of Beauveria bassiana in cotton plant and its effect against insect pests
Authors: Amutha M.
Published: November 2022

The aim of the present study was to evaluate the efficiency of artificial establishment of Beauveria bassiana as endophyte in cotton plant using different inoculation methods, and aimed to determine the effect of colonisation in cotton plant on key insect pests of cotton. Eight strains of B. bassiana isolated as endophytes were used in this experiment. The strains B. bassiana isolated as endophytes were concentrated at 1×108 conidia ml ?1 and bioassays were conducted under laboratory conditions on Aphis gossypii, Spodoptera litura and Pectinophora gossypiella. These endophytic strains demonstrated high virulence against above mentioned insects. Different inoculation methods were used to establish B. bassiana as endophyte in cotton plants. Endophytic colonisation of B. bassiana was successful in cotton plant. Beauveria bassiana colonised plant infested with insect was monitored at different time intervals. Survival of the insect was affected considerably in the B. bassiana inoculated plant. The current study clearly indicated that strains of B. bassiana isolated as endophytes caused the mortality of A. gosypii, S. litura and P. gossypiella as an entomopathogen and also as an endophyte.
Beauveria bassiana as an effective IPM component against cotton stem weevil Pempherulus affinis Faust
Authors: Priyatharsini G. , Premalatha K. , Krishnamoorthy S. V. , Sathiah N. , Senguttuvan K.
Published: November 2022

The Integrated Pest Management (IPM) in reduction of cotton stem weevil in ecofriendly manner is attaining importance in recent days. In present study, three treatments including IPM module 1, IPM module 2 and farmers’ practice were imposed against cotton stem weevil in a field trial. Among the three treatments, IPM module 2 which included basal application of FYM 25 t/ha and 250 kg/ha of neem cake, seed treatment with Beauveria bassania @10g/kg of seed, border crop with Hibiscus cannabinus, soil drenching with Imidacloprid 17.80 SL @ 25 g a.i./ha (125 ml/ha) at 15 DAS and placement of cotton stem bits (25 kg/500box/ha) + Hibiscus cannabinus stem bits (25 kg/500box/ha) + Chlorpyriphos dust 1.5 DP (2.5 kg/500box/ha) @ 30 DAS followed by earthing up @ 30 DAS recorded least stem weevil infestation of 13.21% with a yield of 1642.75 kg/ha. It was followed by IPM module 1 (21.78%) and farmers’ practice (33.56%) with yield of 1456.25 kg/ha and 1588.25 kg/ha, respectively. The mean survival of plants was also higher in IPM module 2 (94.28%) followed by farmers’ practice (88.57%) and IPM module 1 (80.00%).
Characterisation of native Bacillus thuringiensis isolates toxicity to fall armyworm, Spodoptera frugiperda (J.E. Smith)
Authors: Maheesha M. , Balasubramani V. , Murugan M. , Raveendran M. , Rajadurai G. , Tamilnayagan T. , Kokiladevi E. , Sathiah N.
Published: November 2022

Toxicity of nine indigenous Bacillus thuringiensis (Bt) isolates collected from Tamil Nadu, India were tested against fall armyworm, Spodoptera frugiperda. At 30 ?g/ml concentration, two Bt isolates viz., T350 and T532 recorded 100 per cent mortality whereas isolates T527 and T532 registered 96 per cent mortality against neonate larvae of S. frugiperda in leaf dip bioassay. SDS PAGE analysis of spore crystal mixture revealed the presence of Cry1 and Cry2 proteins with visible bands at 130 kDa and 65 kDa. PCR screening results showed the presence of cry1 (cry1A, cry1Aa, cry1Ab), cry2 (cry2Aa, cry2Ab) in four isolates and vip3A genes in three isolates but cry9 gene was not present in any of the isolates tested.
Do Sectoral Indices React Differently to Lockdowns Imposed Due to Covid-19? Lessons for Wealth Generation
Authors: Agarwal Saurabh , Agarwal Megha , Ghosh Renu
Published: November 2022

This research paper is an attempt to study the impact of Covid-19 on the sectoral indices using Event Study Methodology (EVM) and regression models. It tries to analyze the differences in mean returns of one composite and ten sectoral indices on India’s premier National Stock Exchange during four periods-before lockdowns, during the lockdown, during unlocking and post unlock. The analysis is based on 15346 daily observations. Imposition of Lockdown is found to have a positive impact on the daily mean return of the eleven Nifty indices under study. The mean returns of sectoral indices are compared using non-parametric tests. The mean returns across four periods are compared using Friedman’s ANOVA and are found to be significantly different over the four periods. Post Hoc Analysis using Wilcoxon signed-rank test revealed that the daily mean returns during the lockdown were more than the daily mean returns during the period before lockdown, during unlock period or post unlock period. Kruskal Wallis test was used to investigate the equality of means of eleven indices found, mean returns of indices to be equal to each other during all the four alternate periods studied separately. GARCH (1,1) model is then used to estimate returns and variance of sectoral indices A significant portion of variances in sectoral index returns was explained by the variances in market proxy Nifty 50. The study highlights the emerging relevance of the Energy, FMCG, Healthcare, IT and Pharma sector during the lockdown as the abnormal positive returns have increased in these sectors. Infrastructure, Media and realty sectors have been severely affected due to the lockdown. The robustness of estimated parameters is checked by using a dummy variable regression model and it is found that stock markets were strengthening during the period of lockdown. The results of the dummy variable regression model are in line with the results of the Event Study Methodology (EVM) and GARCH (1,1). Overall, the imposition of lockdown as a policy initiative by the Government of India helped in mitigating the effect of Covid-19 on the stock market.
PLFA Profiling of Coal Mine Spoil: An Integrated Approach for the Assessment of Ecological Restoration
Authors: Agrawal Payal , Maharana Jitesh Kumar , Patel Amiya Kumar
Published: November 2022

Coal mine overburden spoil created aftermath of mining activities represents disequilibrated geomorphic system. The pedodiversity including its link with biodiversity and landscape ecology describe the spatial diversity has emerged as functional determinants of ecosystem processes. Being the driving force mediating soil processes, ecosystem restoration through mine spoil genesis is monitored based on the shift in microbial community structure in different age series coal mine spoil. Phospholipid fatty acid analysis is culture-independent approach, which provides a set of molecular markers to determine microbial community composition and discriminate microbial communities of different origin. PLFAs are synthesized during microbial growth, rapidly degraded following cell death and reliably reflect living microbial communities. Relative distribution of 51 PLFAs revealed significant variation in microbial community structure across the sites with Shannon diversity index varies from 1.5265 (OB0) to 2.0139 (OB15) and Pielous evenness index from 0.4110 (OB0) to 0.5260 (OB15). Fungal to bacterial ratio exhibited an increasing trend from OB0 (0.055) to OB15 (0.348) over time, which revealed the sign of mine spoil genesis. The principal component analysis and redundancy analysis discriminate different age series coal mine spoil into independent clusters, which evaluated the broad scale patterns of microbial community structure influencing the pace and progress of mine spoil genesis.
A Critical Assessment of the Relationship between P/E Ratio, RONW and ROCE: A study of FMCG, IT and Banking Sectors
Authors: Jeevitha R. , Rema V.
Published: November 2022

Stock investing requires careful analysis of financial data to find out the company’s true worth. Valuation ratios and Return ratios can predict the share price performance, giving investors an opportunity to know if a stock is overvalued or undervalued. Data for the period from 2010 to 2020 is considered for the study. Price- Earnings ratio (P/E ratio), Return on Net Worth (RONW) and Return on Capital Employed (ROCE) for the top five companies in the FMCG, Banking, and IT sectors are taken for the study. The relationship between the identified variables has been analysed using correlation and linear regression techniques. The analysis reflects that there is a positive relationship between the P/E Ratio with RONW and ROCE for most of the companies in all three sectors. While many factors influence the investment decision, the P/E ratio is an important metric to consider. For the companies across the various sectors, it is evident that the ROCE and RONW have a very strong correlation and also exert influence on the P/E ratio. Therefore, a simple linear regression model is used to demonstrate the relationship between the P/E ratio and ROCE and P/E ratio and RONW. For all the companies across the sectors, a positive relationship is reflected between the P/E ratio and RONW and ROCE. It is essential to analyze the ratios together to get a comprehensive understanding of the financial performance of companies.
Privatisation and Corporate Governance Efficiency: Liquidity Ratio Assessment of the Nigerian Cement Industry
Authors: Gombe Bappayo Masu , Balami Dahiru Hassan , Magaji Sule , Musa Ibrahim
Published: November 2022

The study examines how privatization affects public corporations’ corporate governance efficiency in the management of the liquidity ratio of the Nigerian cement industry. The observed variables are liquidity ratio and fourteen Corporate Governance proxies as dependent variables and independent variables. Secondary data were outsourced from the cement firms. Descriptive statistics and Pooled OLS regressions were used for analysis. Results suggest that the factors affecting corporate governance efficiency and causing capacity underutilization in the cement industry are macro-economic challenges and the weak private sector. The average total market value of shares, average foreign ownership, the average percentage of executive directors and average workforce has a positive impact on the Cement industry’s performance. However, privatization harms the performance of the company. Likewise, corporate governance has a significant impact on the liquidity ratio of the 1cement industry in Nigeria. The study recommends that corporate governance should reduce the liquidity ratios via long-term investment that will enhance return on investment. In addition, suggests devising strategies for proper liquidity and risk management to enhance financial performance and move towards sustainability and growth.
Cellular Immunity in Mice Vaccinated with Recombinant Phospholipase D Toxoid of Hemiscorpius lepturus Scorpion
Authors: Safari-Foroushani Narges , Modarressi Mohammad Hossein , Bagheri Kamran Pooshang , Behdani Mahdi , Shahbazzadeh Delavar
Published: November 2022

Background: Hemiscorpius lepturus is one of the most dangerous scorpions in Iran and the world. Numerous studies have been conducted on phospholipases, especially phospholipase D, in this scorpion’s venom, and the results have shown this protein to be the main cause of death. Therefore, one of the most effective ways of preventing fatalities is to produce a toxoid vaccine from the deadly toxin of the venom. The present study was conducted to assess the non-toxicity of this toxoid and the safety of the vaccine candidate in BALB/c mice.
Methods: The production of interferon-gamma and interleukin-4 cytokines in the spleen cells of the mice was measured using ELISpot assay 28 days following immunization with rPLD toxoid.
Results: The unpaired t-test results showed a significant increase in the concentration of IFN-γ cytokine in the vaccinat­ed mice (P= 0.001), indicating that the immune system is directed toward the Th1 pattern, while no significant differ­ence was observed in the levels of IL-4 (P= 0.16) despite an increase in this cytokine. The in-vivo tests showed that the mice immunized with interval doses of 80µg of toxoid were completely protected against 10 × the LD100 of the venom. Moreover, the toxoid had no dermonecrotic effects and caused no necrotic and inflammatory complications in the rabbit skin.
Conclusion: As a vaccine, the toxoid has the potential to increase the Th1 cytokine response and, subsequently, in­crease acquired cellular immunity. Thus, this toxoid appears to be able to provide an effective vaccine against the ven­om of Hemiscorpius lepturus.
Spatial Distribution, Seasonal Abundance and Physio-Chemical Assessment of Mosquito Larval Breeding Sites in Mardan District, Khyber Pakhtunkhwa, Pakistan
Authors: Gul Sara , Khan Khurshaid , Sajjad Muhammad , Jamal Muhsin , Ullah Mujeeb , Rehman Gauhar , Ali Abid
Published: November 2022

Background: Mosquitoes (Diptera: Culicidae) are haemotophagus insects and are vectors of many arthropod-borne diseases. Present study aimed to explore species composition, seasonal abundance, spatial distribution and physio-chemical properties of larval breeding sites of mosquitoes in District Mardan, Khyber Pakhtunkhwa, Pakistan.
Methods: Both adults and larvae of mosquitoes were collected through light traps, insecticide spray, mouth aspirator and larval standard dipping method in District Mardan from May to November 2017. Water samples from larval sites were physio-chemically analysed.
Results: 5078 (3704 adults and 1374 larvae) mosquito specimens were collected in Mardan, Katlang and Takhtbhai tehsils. Six species in four genera were reported. Culex pipiens (89.80%) and Armigeres subalbatus (9.20%) were the most abundant species. Diversity was high in Takhtbhai (0.29) followed by Katlang (0.28) and Mardan (0.25). Greater number of specimens were recorded in peridomestic sites (93.97%) as compared to domestic habitats (6.03%). Culex pipiens larval abundance had negative correlation with pH whereas it correlated positively with electric conductivity, salinity, and TDS (total dissolved sulphur). Mosquito abundance peaked in August and July while the lowest was in May. Their monthly abundance had positive correlation with rainfall (r= 0.5069), relative humidity (r= 0.4439) and mean minimum temperature (r= 0.2866). Number of mosquitoes was highest at low elevation < 347m asl (above sea level) in agriculture land and near to water bodies (streams).
Conclusion: Culex pipiens being the most abundant species, was susceptible to high pH. Mosquitoes preferred habitats were at low elevation in agriculture land.
Anti Leishmanial Effect of Plantago psyllium (ovate) and White Vinegar on Leishmania major Lesion in BALB/c Mice
Authors: Moshfe Abdolali , Karami Keianoush , Bahmani Maryam , Naghmachi Mohsen , Askarian Shahrbanoo , Rezaei Abbas , Zare Roohallah , Jamshidi Ali
Published: November 2022

Background: Leishmania major is the etiologic agent of zoonotic cutaneous leishmaniasis in Iran, and glucantime in­jection is currently used for its treatment. This study aimed to evaluate the anti-leishmanial effect of topical Plantago psyllium and white vinegar in L. major infected BALB/c mice.
Methods: Thirty infected mice were divided into five groups as follows: Group‌ 1: treated with the combination of ovata powder and white vinegar, Group 2: treated with glucantime, Group 3: treated with white vinegar, Group 4: treated with the combination of ovata powder and water, and Group 5: without any treatment. All the groups were treated for 18 days. Lesion size was measured, and final smears were prepared for microscopic examination.
Results: The findings indicated that the difference in the mean areas of the ulcers in all the groups before and after treatment was not significant, except for the second (glucantime) and third (vinegar) groups. Also, the results showed that in the first, second, third, and fourth group, 6 (60%), 4 (80%), 3 (60%), and 2 (40%) mice were healed, respective­ly. However, ulcers remained in all the five mice of the control group.
Conclusion: The combination of ovata powder and white vinegar has been traditionally used to treat leishmanial lesions in Iran. It seems the most anti-leishmanial effect is related to vinegar and supported by Plantago. The route of treatment with this combination is very simple and painless in comparison with injection. Thus, further studies on this issue could help to design more effective and easy-to-use drugs.
Ectoparasites Diversity on Rodents and Shrews at Scrub Typhus Endemic Vellore District of Tamil Nadu, India
Authors: Paulraj Philip Samuel , Renu Govindarajan , Ranganathan Krishnamoorthi , Veeramanoharan Rajamannar , Kumar Ashwani
Published: November 2022

Background: Rodents and shrew living in the vicinity of human beings perform significant role to harbor different spe­cies of ectoparasites and thus act as the reservoir host for the spread of diseases to human and animals.
Methods: This study was undertaken to determine the species composition of the medically important ectoparasites present in the scrub typhus affected places of Vellore District using wonder and Sherman traps for trapping of live Ro­dent/Shrew during September 2017 to August 2018.
Results: Rodent/shrew hosts belonged to two Families, three sub families and five genera and five different species. These animals carried 23 species of ectoparasites including 17 trombiculid mites, two non-trombiculid mites, two ticks and two fleas. A total of 940 chigger mites were collected which belonged to three Tribes, six Genera, two Subgenera and 17 species. Adult mites collected belonged to two families, three genera and three species. Ticks collected were classified under one family, two genera and two species. Fleas fall under one family, one subfamily, one tribe, one ge­nus and two species.
Conclusion: This is the first record of 14 species of chigger mites and three species of adult mites from Vellore District, Tamil Nadu. Surveillance of these keystone ectoparasites helped to identify the medically important disease vectors causing acari-borne zoonotic diseases.
Discharge planning practice for patients with colorectal cancer in Thailand
Authors: Duangchan Cherdsak , Steffen Alana , Matthews Alicia K.
Published: November 2022

Background & Aim: Nurses play a vital role in discharge planning, especially for patients with colorectal cancer who require complex post-treatment care. However, there is a limited understanding of nurses' discharge planning practice in oncology settings. This study aimed to examine current discharge planning practices for patients with colorectal cancer among oncology nurses in Thailand and associated factors.
Methods & Materials: A cross-sectional survey study was conducted between October and November 2020. Oncology nurses involved in colorectal cancer care were recruited across Thailand via Facebook and the Line application. A convenience and snowball sample of 206 nurses completed the online survey. Descriptive statistics, t-test, and one-way ANOVA were used for data analysis.
Results: The discharge planning activity with the lowest mean score was related to sharing discharge planning summaries and/or care plans with other healthcare facilities (M = 3.00, SD= 1.32), followed by providing information about returning to work (M= 3.06, SD= 1.28), financial resources (M= 3.12, SD= 1.26), and disease (M= 3.13, SD= 1.25). Factors significantly associated with discharge planning practice included nursing education levels, specialty training in cancer care, and experience in colorectal cancer care.
Conclusion: Despite the availability of discharge planning guidelines, Thai oncology nurses did not perform the full scope of discharge planning activities required for patients with colorectal cancer. Additional strategies, resources, and support systems should be established to facilitate nurses' performance of the full scope of their discharge planning practice in oncology settings. Moreover, our results suggest the need for additional education and training in the form of enhanced curriculums and continuing education seminars addressing cancer care to advance nurses' discharge planning for patients with colorectal cancer.