bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing nasolabial cyst: Experience at a tertiary care teaching hospital in Eastern India
Authors: Swain Santosh Kumar , Dubey Debasmita
Published: December 2023

Background:

Nasolabial cysts are non-odontogenic cysts that arise from the nasal alar area. Sublabial resection of the nasolabial cyst is considered an effective surgical modality of treatment.

Objective:

This study aimed to evaluate the clinical presentation, diagnosis and treatment of nasolabial cyst at a tertiary care teaching hospital in eastern India.

Methods:

This was a retrospective study of 38 cases of nasolabial cysts managed between May 2018 and June 2022. The detailed clinical presentations, investigations and treatment of nasolabial cysts of the patients were studied.

Results:

Out of 38 cases of the nasolabial cyst, 22 (57.9%) were seen on the left side, 13 (34.2%) were seen on the right side and 3 were seen bilaterally. The most common presenting complaint was facial swelling (84.2%). Computed tomography of the nose and paranasal sinuses was done in 24/38 (70.5%) patients studied. Surgical excision of the nasolabial cysts was done by intraoral sublabial approach in 32 (84.2%) cases and 6 underwent endoscopic transnasal marsupialisation. The most common post-operative complication was post-operative facial/perinasal swelling. One case of recurrence was reported who underwent endoscopic transnasal marsupialisation.

Conclusions:

Nasolabial cysts are an uncommon clinical entity but manifest cosmetic deformity and nasal obstruction. Intraoral sublabial excision and endoscopic transnasal marsupialisation are important surgical techniques for the nasolabial cyst. The post-operative complications and chance of recurrence are rare.
Paroxysmal nocturnal haemoglobinuria presenting as cortical cerebral venous thrombosis
Authors: Nouduri Abhishek Venkata , Talasila Akshara Sai Sri , Shetty Mallikarjuna , Khaleelullah Syed , Srikanth Rama , Iyer Aishwarya
Published: December 2023

Paroxysmal nocturnal haemoglobinuria (PNH) arises as a consequence of mutation of phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene that is required for synthesis of the glycosylphosphatidylinositol proteins to the cell surface of blood cells. Patients with PNH usually present with features of chronic unexplained anaemia, but can also present with bone marrow failure and thrombosis at unusual sites. We present the case of a 27-year-old who presented with complaints of headache and easy fatigability, on evaluation was found to have coombs negative haemolytic anaemia and brain magnetic resonance venogram revealed thrombosis in the left transverse and sigmoid sinuses. On further investigation, found to have PNH clone in both red and white blood cell lineages and diagnosed as PNH. Hence, any patient presenting with chronic non-immune intravascular haemolysis, unexplained anaemia and unusual thrombosis should alert the physician to consider PNH as a differential diagnosis to avoid delay in diagnosis and better management.
An unusual case of angioedema
Authors: Naini Abhilash , Sree Aakula Suguna , Talasila Akshara Sai Sri , Pappu Sai Subrahmanyam , Shetty Mallikarjuna
Published: December 2023

A 40-year-old female with diabetes mellitus and hypothyroidism presented with a 15 days history of itching all over the body associated with urticarial rash which resolved spontaneously and rapid-onset facial swelling and stiffness for 10 days with the inability to open eyelids due to swelling. On physical examination, the face was swollen diffusely with restriction of eye and mouth opening due to the swelling. In view of unresponsiveness to parenteral steroids and antihistamines, non-allergic causes of angioedema were suspected. Peripheral blood smear examination revealed 55% atypical cells. Bone marrow aspirate examination was suggestive of acute myeloid leukaemia with monocytic differentiation.
Extensive venous thrombosis – A rare presentation of ulcerative colitis in a young female
Authors: Durgam Ramya , Hussain Gundluru Zakeer , Harshitha Bonam , Raju Y. Sathyanarayana
Published: December 2023

Extraintestinal manifestations (EMs) are well recognised in association with ulcerative colitis (UC). Immunologically mediated and thrombotic events are uncommon manifestations of this disease. We present the case of a 28-year-old female with a 2-year history of loose stools presenting with bilateral lower limb oedema. On evaluation, extensive deep venous thrombosis of bilateral lower limbs extending to the inferior vena cava and acute on chronic pulmonary thromboembolism was evident. Laboratory evaluation demonstrated anaemia, leucocytosis, elevated C-reactive protein and erythrocyte sedimentation rate, positive perinuclear antinuclear cytoplasmic antibody, antinuclear antibody-immunofluorescence and stool for occult blood. Colonoscopy and histopathological examination of colonic mucosa were suggestive of inflammatory bowel disease favouring the diagnosis of UC. She was started on oral prednisolone 20 mg daily with brisk improvement in her anaemia. She was therapeutically anticoagulated for extensive venous thrombosis. She continued to deteriorate and developed severe respiratory distress and cardiogenic shock and was given mechanical ventilatory support. This case report reviews venous thrombosis as a rare extraintestinal complication of UC, including the presentation, diagnosis and treatment.
Paravertebral extramedullary haematopoiesis mimicking myeloid sarcoma
Authors: Debahuti Mohapatra , Das Prateek , Govardhan Tulasi , Kumar Bhola Rajesh
Published: December 2023

Extramedullary haematopoiesis (EMH) is the formation and development of blood cells outside the bone marrow. They are benign process associated with myeloproliferative disorders, haemolytic anaemia, hereditary spherocytosis and Gaucher’s disease. The common locations for EMH are reticuloendothelial system, namely liver, spleen and lymph node. However, other locations such as lung, urogenital system, retroperitoneum and mediastinum are rare sites of occurrence. A 50-year-old male, with sickle cell disease, presented with a history of dyspnoea and backache showing a bilateral mass in the paravertebral (thoracic) region, pleural thickening and small mass in the lung. The clinical diagnosis was lung neoplasm. The needle core biopsy was obtained from the paravertebral mass. Microscopy showed trilineage haemopoietic proliferation along with few fat cells. Thus, the diagnosis of EMH was made. Being a rare benign entity, EMH often mimics malignancy as well as granulocytic sarcoma which show the presence of acute or chronic leukaemia, presence of increased eosinophilic precursor and increased number of myeloblasts. Thus, the awareness of the entity as well as early diagnosis helps the patient in appropriate management of this benign yet rare entity.
Bleomycin for Intralesional Sclerotherapy of Haemangioma in the Oral Mucosa: Case Report and Mini Review of Literature
Authors: Nazar Jincy , Philip Rony Mukkoottil
Published: December 2023

Haemangiomas are benign congenital anomalies of the vascular system. Percutaneous sclerotherapy is used to treat vascular malformations, which can cause significant discomfort and/or disfigurement. In this article, we present the clinical case of a female patient diagnosed with a superficial capillary haemangioma of the gingiva at the age of adulthood, where two intralesional injections with a solution of bleomycin were performed at 1-month intervals between them, with very good aesthetic and functional results, only 3 months after starting therapy and the authors investigate the effectiveness and safety of bleomycin injections for vascular malformations regarding size reduction, symptom relief, quality of life, adverse events (including pulmonary fibrosis) and patient satisfaction.
Stem cells and pain
Authors: Silva Matheus Deroco Veloso da , Piva Maiara , Martelossi-Cebinelli Geovana , Stinglin Rosa Ribas Mariana , Hoffmann Salles Bianchini Beatriz , K Heintz Olivia , Casagrande Rubia , Verri Jr Waldiceu A
Published: December 2023

Pain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant experience. For years, science has sought to find treatment alternatives, with minimal side effects, to relieve pain. However, the currently available pharmacological options on the market show significant adverse events. Therefore, the search for a safer and highly efficient analgesic treatment has become a priority. Stem cells (SCs) are non-specialized cells with a high capacity for replication, self-renewal, and a wide range of differentiation possibilities. In this review, we provide evidence that the immune and neuromodulatory properties of SCs can be a valuable tool in the search for ideal treatment strategies for different types of pain. With the advantage of multiple administration routes and dosages, therapies based on SCs for pain relief have demonstrated meaningful results with few downsides. Nonetheless, there are still more questions than answers when it comes to the mechanisms and pathways of pain targeted by SCs. Thus, this is an evolving field that merits further investigation towards the development of SC-based analgesic therapies, and this review will approach all of these aspects.
Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment
Authors: Abu-El-Rub Ejlal , Almahasneh Fatimah , Khasawneh Ramada R , Alzu'bi Ayman , Ghorab Doaa , Almazari Rawan , Magableh Huthaifa , Sanajleh Ahmad , Shlool Haitham , Mazari Mohammad , Bader Noor S , Al-Momani Joud
Published: December 2023

BACKGROUND

Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases. Diabetes mellitus (DM) is a frequently diagnosed chronic disease characterized by hyperglycemia which initiates many multisystem complications in the long-run. DM patients can benefit from MSCs transplantation to curb down the pathological consequences associated with hyperglycemia persistence and restore the function of damaged tissues. MSCs therapeutic outcomes are found to last for short period of time and ultimately these regenerative cells are eradicated and died in DM disease model.

AIM

To investigate the impact of high glucose or hyperglycemia on the cellular and molecular characteristics of MSCs.

METHODS

Human adipose tissue-derived MSCs (hAD-MSCs) were seeded in low (5.6 mmol/L of glucose) and high glucose (25 mmol/L of glucose) for 7 d. Cytotoxicity, viability, mitochondrial dynamics, and apoptosis were deplored using specific kits. Western blotting was performed to measure the protein expression of phosphatidylinositol 3-kinase (PI3K), TSC1, and mammalian target of rapamycin (mTOR) in these cells.

RESULTS

hAD-MSCs cultured in high glucose for 7 d demonstrated marked decrease in their viability, as shown by a significant increase in lactate dehydrogenase (P < 0.01) and a significant decrease in Trypan blue (P < 0.05) in these cells compared to low glucose control. Mitochondrial membrane potential, indicated by tetramethylrhodamine ethyl ester (TMRE) fluorescence intensity, and nicotinamide adenine dinucleotide (NAD+)/NADH ratio were significantly dropped (P < 0.05 for TMRE and P < 0.01 for NAD+/NADH) in high glucose exposed hAD-MSCs, indicating disturbed mitochondrial function. PI3K protein expression significantly decreased in high glucose culture MSCs (P < 0.05 compared to low glucose) and it was coupled with significant upregulation in TSC1 (P < 0.05) and downregulation in mTOR protein expression (P < 0.05). Mitochondrial complexes I, IV, and V were downregulated profoundly in high glucose (P < 0.05 compared to low glucose). Apoptosis was induced as a result of mitochondrial impairment and explained the poor survival of MSCs in high glucose.

CONCLUSION

High glucose impaired the mitochondrial dynamics and regulatory proteins in hAD-MSCs ensuing their poor survival and high apoptosis rate in hyperglycemic microenvironment.
Cell-type specific role of autophagy in the liver and its implications in non-alcoholic fatty liver disease
Authors: Raza Sana , Rajak Sangam , Singh Rajani , Zhou Jin , Sinha Rohit A , Goel Amit
Published: December 2023

Autophagy, a cellular degradative process, has emerged as a key regulator of cellular energy production and stress mitigation. Dysregulated autophagy is a common phenomenon observed in several human diseases, and its restoration offers curative advantage. Non-alcoholic fatty liver disease (NAFLD), more recently renamed metabolic dysfunction-associated steatotic liver disease, is a major metabolic liver disease affecting almost 30% of the world population. Unfortunately, NAFLD has no pharmacological therapies available to date. Autophagy regulates several hepatic processes including lipid metabolism, inflammation, cellular integrity and cellular plasticity in both parenchymal (hepatocytes) and non-parenchymal cells (Kupffer cells, hepatic stellate cells and sinusoidal endothelial cells) with a profound impact on NAFLD progression. Understanding cell type-specific autophagy in the liver is essential in order to develop targeted treatments for liver diseases such as NAFLD. Modulating autophagy in specific cell types can have varying effects on liver function and pathology, making it a promising area of research for liver-related disorders. This review aims to summarize our present understanding of cell-type specific effects of autophagy and their implications in developing autophagy centric therapies for NAFLD.
Any role for transarterial radioembolization in unresectable intrahepatic cholangiocarcinoma in the era of advanced systemic therapies?
Authors: Elvevi Alessandra , Laffusa Alice , Elisei Federica , Morzenti Sabrina , Guerra Luca , Rovere Antonio , Invernizzi Pietro , Massironi Sara
Published: December 2023

Intrahepatic cholangiocarcinoma (iCCA) is recognized as the second most frequently diagnosed liver malignancy, following closely after hepatocellular carcinoma. Its incidence has seen a global upsurge in the past several years. Unfortunately, due to the lack of well-defined risk factors and limited diagnostic tools, iCCA is often diagnosed at an advanced stage, resulting in a poor prognosis. While surgery is the only potentially curative option, it is rarely feasible. Currently, there are ongoing investigations into various treatment approaches for unresectable iCCA, including conventional chemotherapies, targeted therapies, immunotherapies, and locoregional treatments. This study aims to explore the role of transarterial radioembolization (TARE) in the treatment of unresectable iCCA and provide a comprehensive review. The findings suggest that TARE is a safe and effective treatment option for unresectable iCCA, with a median overall survival (OS) of 14.9 months in the study cohort. Studies on TARE for unresectable iCCA, both as a first-line treatment (as a neo-adjuvant down-staging strategy) and as adjuvant therapy, have reported varying median response rates (ranging from 34% to 86%) and median OS (12-16 mo). These differences can be attributed to the heterogeneity of the patient population and the limited number of participants in the studies. Most studies have identified tumor burden, portal vein involvement, and the patient’s performance status as key prognostic factors. Furthermore, a phase 2 trial evaluated the combination of TARE and chemotherapy (cisplatin-gemcitabine) as a first-line therapy for locally advanced unresectable iCCA. The results showed promising outcomes, including a median OS of 22 mo and a 22% achievement in down-staging the tumor. In conclusion, TARE represents a viable treatment option for unresectable iCCA, and its combination with systemic chemotherapy has shown promising results. However, it is important to consider treatment-independent factors that can influence prognosis. Further research is necessary to identify optimal treatment combinations and predictive factors for a favorable response in iCCA patients.
Serum omentin-1 is correlated with the severity of liver disease in patients with chronic hepatitis C
Authors: Peschel Georg , Weigand Kilian , Grimm Jonathan , Müller Martina , Buechler Christa
Published: December 2023

BACKGROUND

Patients with chronic hepatitis C virus (HCV) infection have increased serum omentin-1. Omentin-1 is an anti-inflammatory adipokine, and higher levels may be a direct effect of HCV infection. Successful elimination of HCV by direct acting antivirals almost normalized circulating levels of various molecules with a role in inflammation.

AIM

To evaluate the effect of HCV infection on serum omentin-1, serum omentin-1 levels of HCV patients were measured before therapy and at 12 wk after therapy end. Associations of serum omentin-1 with parameters of inflammation and liver function were explored at both time points. Serum omentin-1 levels of patients with and without liver cirrhosis, which was defined by ultrasound or the fibrosis-4 (FIB-4) score, were compared.

METHODS

Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay in 84 chronic HCV patients before therapy and at 12 wk after therapy end where sustained virological response 12 (SVR12) was achieved in all patients. Serum omentin-1 of 14 non-infected controls was measured in parallel.

RESULTS

In patients with chronic HCV, serum omentin-1 levels were not related to viral load or viral genotype. HCV patients with liver steatosis and HCV patients with diabetes had serum omentin-1 levels comparable to patients not suffering from these conditions. Serum omentin-1 levels at SVR12 were similar in comparison to pretreatment levels. In addition, serum levels did not differ between HCV-infected patients and non-infected controls. Serum omentin-1 levels did not correlate with leukocyte count or C-reactive protein. Positive correlations of serum omentin-1 with bilirubin and the model for end-stage liver disease score (MELD) were detected before therapy and at SVR12 in the whole cohort. Bilirubin and the MELD score also positively correlated with serum omentin-1 levels in the subgroup of patients with ultrasound diagnosed liver cirrhosis before therapy. At SVR12, serum omentin-1 levels of patients with liver cirrhosis negatively correlated with albumin. Before therapy start, patients with high FIB-4 scores had increased serum omentin-1 in comparison to patients with a low score. Serum omentin-1 levels of patients with liver cirrhosis defined by ultrasound were increased at baseline and at SVR12.

CONCLUSION

Present study showed that liver cirrhosis, but not HCV infection per se, is related to elevated serum omentin-1 levels.
Methods for improving colorectal cancer annotation efficiency for artificial intelligence-observer training
Authors: Grudza Matthew , Salinel Brandon , Zeien Sarah , Murphy Matthew , Adkins Jake , Jensen Corey T , Bay Curtis , Kodibagkar Vikram , Koo Phillip , Dragovich Tomislav , Choti Michael A , Kundranda Madappa , Syeda-Mahmood Tanveer , Wang Hong-Zhi , Chang John
Published: December 2023

BACKGROUND

Missing occult cancer lesions accounts for the most diagnostic errors in retrospective radiology reviews as early cancer can be small or subtle, making the lesions difficult to detect. Second-observer is the most effective technique for reducing these events and can be economically implemented with the advent of artificial intelligence (AI).

AIM

To achieve appropriate AI model training, a large annotated dataset is necessary to train the AI models. Our goal in this research is to compare two methods for decreasing the annotation time to establish ground truth: Skip-slice annotation and AI-initiated annotation.

METHODS

We developed a 2D U-Net as an AI second observer for detecting colorectal cancer (CRC) and an ensemble of 5 differently initiated 2D U-Net for ensemble technique. Each model was trained with 51 cases of annotated CRC computed tomography of the abdomen and pelvis, tested with 7 cases, and validated with 20 cases from The Cancer Imaging Archive cases. The sensitivity, false positives per case, and estimated Dice coefficient were obtained for each method of training. We compared the two methods of annotations and the time reduction associated with the technique. The time differences were tested using Friedman’s two-way analysis of variance.

RESULTS

Sparse annotation significantly reduces the time for annotation particularly skipping 2 slices at a time (P < 0.001). Reduction of up to 2/3 of the annotation does not reduce AI model sensitivity or false positives per case. Although initializing human annotation with AI reduces the annotation time, the reduction is minimal, even when using an ensemble AI to decrease false positives.

CONCLUSION

Our data support the sparse annotation technique as an efficient technique for reducing the time needed to establish the ground truth.
Efficacy and prognostic impact of Pericarpium Trichosanthis injection combined with nicorandil for intractable angina pectoris in elderly patients: A retrospective study
Authors: Li Jun , Kong Mo-Wei , Xie Yu-Yu , Wang Ze-Bi , Xu Li , He Guo-Xiang
Published: December 2023

BACKGROUND

Coronary artery disease (CAD) is a leading cause of global cardiovascular mortality. Refractory angina pectoris, a manifestation of CAD, requires effective drug treatments. Pericarpium Trichosanthis injection, a traditional Chinese medicine, improves cardiovascular symptoms, while nicorandil alleviates spasms and angina. Both have potential in treating CAD.

AIM

To investigate the therapeutic effects of combining Pericarpium Trichosanthis injection and nicorandil in elderly patients suffering from refractory angina caused by coronary heart disease.

METHODS

A retrospective analysis was conducted on the data of 130 patients diagnosed with refractory coronary heart disease. Based on the different treatment regimens administered during hospitalization, the patients were divided into a control group (58 cases) and a study group (72 cases). The control group received conventional treatment, which included aspirin, statins, and nitrate vasodilators. In addition to the conventional medication, the study group received a combination treatment of Pericarpium Trichosanthis injection and nicorandil.

RESULTS

After treatment, the study group showed significantly higher left ventricular ejection fraction and cardiac output, and lower brain natriuretic peptide and C-reactive protein levels compared to the control group. The study group also exhibited improvements in angina, quality of life, exercise endurance, and lipid profiles. Multivariate logistic regression analysis revealed a relationship of lipid levels and heart function with the combined treatment. Some patients in the study group experienced headaches during treatment, but no significant adverse reactions were observed. Follow-up showed that the treatment was well-tolerated, with no drug-related adverse reactions detected.

CONCLUSION

Combination of Pericarpium Trichosanthis injection and nicorandil is more effective than conventional treatment in improving symptoms and heart function in elderly patients with refractory angina pectoris.
Pulmonary and tricuspid regurgitation after Tetralogy of Fallot repair: A case report
Authors: Cao Jing-Yi , Ning Xiao-Ping , Zhou Guang-Wei , Li Bai-Ling , Qiao Fan , Han Lin , Xu Zhi-Yun , Lu Fang-Lin
Published: December 2023

BACKGROUND

Tetralogy of Fallot (TOF) is one of the most common congenital heart defects, and surgery is the primary treatment. There are no precise guidelines on the treatment protocol for tricuspid regurgitation (TR) as a common complication of TOF repair. The timing for treatment in patients presenting with valve regurgitation after TOF repair is often difficult to determine. Here, we report the first case of sequential treatment of pulmonary and TR using interventional therapy.

CASE SUMMARY

We present the case of a 52-year-old female patient, who had a history of TOF repair at a young age. A few years later, the patient presented with pulmonary and tricuspid regurgitation. The symptoms persisted and TR worsened following percutaneous pulmonary valve implantation. Preoperative testing revealed that the patient’s disease had advanced to an intermediate to advanced stage and that her general health was precarious. Because open-heart surgery was not an option for the patient, transcatheter tricuspid valve replacement was suggested. This procedure was successful, and the patient recovered fully without any adverse effects. This case report may serve as a useful resource for planning future treatments.

CONCLUSION

Treatment of both valves should be considered in patients with tricuspid and pulmonary regurgitations following TOF repair. The interventional strategy could be an alternative for patients with poor general health.
İlk Zâhidlerden Riyâh b. Amr el-Kaysî Hakkındaki Zındıklık ve Râbia el-Adeviyye ile Evliliği İddiaları Üzerine Bir Değerlendirme
Authors: ARSLAN Ahmet
Published: December 2023

Bu makale; zühd döneminin önemli simalarından Riyâh b. Amr el-Kaysî’nin hayatını, zühd anlayışını, hakkındaki iddiaları ve Râbia el-Adeviyye ile olan ilişkilerini ele almaktadır. Zühd döneminde yaşayan zâhidlerin hayat tarzları ve fikirleri, tasavvufî düşüncenin temelini oluşturmuştur. Ancak bazı zâhidler, eleştirilere de maruz kalmıştır. Eleştirilen zâhidlerin biri hicrî II. asırda Basra’da yaşayan Riyâh b. Amr el-Kaysî’dir. Riyâh, Ebû Dâvûd-es-Sicistânî ve Ebü’l-Hüseyin el-Malatî tarafından zındıklıkla itham edilmiştir. Malatî’ye göre Riyâh, Allah sevgisiyle hüllet makamına erdiğinden şeriat emirleriyle mükellef olmadığını ileri sürmüştür. Ayrıca son dönem araştırmacıları, Riyâh’ın Râbia el-Adeviyye ile evli olabileceğini öne sürmüşlerdir. Bu çalışmanın amacı Riyâh b. Amr el-Kaysî’nin zühd anlayışını, hakkındaki ithamları, Râbia el-Adeviyye ile olan ilişkilerini ayrıntılı bir şekilde incelemektir. Çalışmada önce Riyâh’ın hayatı, bulunduğu zühd ortamı ve zühd anlayışı ortaya konmuş, ardından bu bilgiler ışığında hakkındaki iddialar incelenmiştir. Araştırma neticesinde Riyâh’ın dinî inançlardan uzak bir yaşamının olmadığı, aksine katı bir zühd hayatı sürdüğü, bu nedenle zındıklıkla itham edildiği ve Adana’daki Yakapınar’da (Misis) şehit düştüğünün rivayet edildiği anlaşılmıştır.
Robustness against Read Committed for Transaction Templates with Functional Constraints
Authors: Vandevoort Brecht , Ketsman Bas , Koch Christoph , Neven Frank
Published: December 2023

The popular isolation level Multiversion Read Committed (RC) trades some of
the strong guarantees of serializability for increased transaction throughput.
Sometimes, transaction workloads can be safely executed under RC obtaining
serializability at the lower cost of RC. Such workloads are said to be robust
against RC. Previous work has yielded a tractable procedure for deciding
robustness against RC for workloads generated by transaction programs modeled
as transaction templates. An important insight of that work is that, by more
accurately modeling transaction programs, we are able to recognize larger sets
of workloads as robust. In this work, we increase the modeling power of
transaction templates by extending them with functional constraints, which are
useful for capturing data dependencies like foreign keys. We show that the
incorporation of functional constraints can identify more workloads as robust
that otherwise would not be. Even though we establish that the robustness
problem becomes undecidable in its most general form, we show that various
restrictions on functional constraints lead to decidable and even tractable
fragments that can be used to model and test for robustness against RC for
realistic scenarios.
Dilemma of School Management Teams in Balancing Discipline and Multiple Deprivations among Learners through Integrated Management Approach
Authors: Khanyile Hlengiwe Goodness , Mpuangnan Kofi Nkonkonya
Published: December 2023

The United Nations Convention on the Rights of the Child (UNCRC) has emphasized the paramount importance of ensuring the safety and protection of children globally. In alignment with this goal, the South African government took a proactive step by prohibiting corporal punishment as a means of disciplining learners within schools. However, this prohibition subsequently led to a resurgence of learner indiscipline within the educational system. The objective of this study was to delve into the experiences of School Management Teams (SMT) employing an integrated management approach to maintain discipline in an environment marked by multiple challenges. Through qualitative research methods involving interviews and document analysis, this study gathered insights from purposively selected participants, including teachers (2), SMT members who are also parents (2), and student leaders (4). Thematic analysis was conducted on the data and findings were categorized based on the emerging themes. The outcomes of this research shed light on several critical factors affecting discipline within schools. Firstly, the leniency exercised by teachers was identified as a significant factor undermining the enforcement of the school code of conduct. Secondly, overcrowded classrooms emerged as a substantial obstacle, making it arduous for teachers to offer individualized attention and promptly address behavioural issues. Lastly, inadequate support from the Department of Basic Education was recognized as a clear barrier to effectively upholding discipline in schools. In light of these findings, it is imperative to advocate for comprehensive training programs and adequate resource allocation for school management teams. These initiatives would equip SMTs to navigate the unique challenges associated with multiple deprivations and effectively manage disciplinary matters. Such investments are indispensable for fostering an environment conducive to effective education and overall growth of learners.
Chasing Light: How Dichromatic LEDs Affect the Elemental Profile of Gongolaria barbata
Authors: YILMAZ Melis , AK İlknur
Published: December 2023

This study aims to investigate the influence of three different dichromatic LED light sources and varying photoperiod durations on the mineral content and trace element compositions in cultivated Gongolaria barbata under controlled culture conditions. During the experiment, red-blue (RB), blue-green (BG), red-green (RG) and fluorescent lights were examined at 16:16, 12:12, and 8:16 Light: Dark (L:D) photoperiods, and at 150 μmol photon m-2 s-1 intensity of light in all treatments. The elemental compositions of the thallus samples were analyzed for Mg, Ca, K, Na, P, Zn, Mo, Cu, Mn, Cr, Co, Cd, Fe, and As.. Our results showed that macro element and trace element compositions significantly varied among different experimental groups. Regarding the order of abundance, macroelements were ranked as follows: K > Na > Ca > Mg > P. Meanwhile, trace elements followed this order: As > Zn > Mn > Cr > Co > Cu > Cd > Mo > Fe. Among the experiment groups, the highest value of the macro elements was recorded as 1041.3±22.2 mg kg-1 for K, and the lowest value was 26.61±0.02 mg kg-1 for the P. Among the trace elements, for As, the highest value was recorded as 1339.86±5.27 µg kg -1, and the lowest was determined at 1.93±0.04 mg kg-1 for the Fe. The findings highlight that LED lighting conditions can significantly influence the elemental composition of G. barbata.
KARIZ SU SİSTEMİNİN UYGUR KÜLTÜRÜNDEKİ SOSYOKÜLTÜREL DEĞERİNİN ARAŞTIRILMASI
Authors: Özçalık Mahire , Cobanoglu Ozkul
Published: December 2023

Doğal kaynaklarn hiçbiri sınırsız değildir. Doğal kaynakları bilinçli şekilde kullanmak, kaynakların ömrünü uzatabilir ve sürdürülebilirliği sağlanabilir. Su kaynağının bilinçsizce kullanılmasından dolayı yer altı tatlı su kaynakları bitmek üzere olup su kıtlığı yaşanmaktadır. Eskiden 30-40 metre derinlikten su alınıyorken günümüzde yer altı su sondajlarının derinliği neredeyse 300-400 metreye ulaşmıştır. Ancak kaliteli suya erişilmek istendiğinde bu derinlik daha da artmaktadır. Bu durumdan yola çıkarak yakın süre zarfında su kaynaklarına ulaşımın zorlaşacağı hatta su kıtlığının meydana geleceğini söylemek mümkündür. Bu durumda su kullanımı hakkında insanları bilinçlendirilmesi ve karız su sitemlerinin tekrardan canlandırılması giderek azalmakta olan su kaynaklarımızın korunmasındaki önemli yöntemlerden biri olabilir. Bu kapsamda, günümüzde iklim değişikliği sonucu karşı karşıya kaldığımız kuraklık sorunları karşısında suyun insanlar ve tüm canlılar için önemi göz önünde bulundurularak Uygur kültüründe karız su sistemlerinin toplum yaşamındaki yeri ve sosyokültürel değerinin araştırılması çalışmada ele alınmıştır. Araştırmanın amacı; iklim değişikliği, küresel ısınma ve özellikle de yanlış kullanımı sonucu suyun azalma tehlikesi ile karşı karşıya kaldığımız bugünlerde, suyun sağlıklı yaşam için temel bir ihtiyaç olduğunu, ekonomik bir mal olmadığı algısını oluşturmak ve ata kültürüne sahip çıkılarak atalarımızın doğa ile uyum içinde suya ve ekolojik dengeye sahip yaşama ilkelerinden yararlanılmasına katkı sağlamaktır
ZORDUN SABİR’İN “DOLAN YAŞLİRİ” (DOLAN GENÇLERİ) ADLI HİKÂYESİNİN ÇÖZÜMLEMESİ
Authors: Zağoğli A. Serdar
Published: December 2023

Çağatay edebiyatının devamı olan, 20. yüzyılın başlarından itibaren temelleri atılan ve konu üzerinde çalışan edebiyat tarihçileri tarafından Çağdaş Uygur Edebiyatı olarak adlandırılan bu süreç, farklı zorluklar ve önemli aşamalardan geçerek bugüne ulaşmıştır. Doğu Türkistan’daki milliyetçi Çin yönetimi, iki kez kurulan Cumhuriyet, Komünist Çin istilası, Kültür Devrimi gibi olaylar edebiyata farklı şekillerde yansımıştır. Ayrıca günümüzdeki soykırım niteliğindeki baskılar Uygur edebiyatının soluğunu kesmiştir. Özgürlük, sosyal baskı, inançsal kısıtlanmalar vb. meseleler hep edebiyatın konusu olmuştur; yazarlar da hoşnutsuzluğunu kalemi aracılığıyla ifade etmiştir.
İkinci Cumhuriyet’in merkezi olan Gulca’da doğup büyüyen Zordun Sabir’in eserlerinde, yaşadığı dönem ve bu dönemdeki Uygur halkının sosyal hayatı ifade edilir. Uygur halkının yaşam biçimi, hayata bakışı ve karşılaştığı farklı sıkıntıları dile getirmesi yönüyle Sabir’in eserleri bir toplumun hafızası niteliği taşır. Türkiye’de yakında Türkçeye çevrilen “Anayurt” adlı üç ciltli tarihî romanı ile tanınan Sabir’in hikâyeleri de ustalığının birer kanıtı mahiyetindedir. Bu makalede Zordun Sabir’in 1979 tarihli, Kültür Devrimi’nden sonra bir köyde geçen olayları anlattığı ya da oradan esinlenerek kaleme aldığı, Uygurların sosyal yaşamı ve düşünce yapısından kareler sunduğu ve dönem şartlarını göz önünde bulundurarak otoriteyi eleştirdiği “Dolan Yaşliri” (Dolan Gençleri) adlı hikâyesi çözümlenecektir.
Bu hikâye metne bağlı inceleme yöntemi ile çözümlenmiş olup yöntem, edebî eseri bir metin olarak görüp öz ve biçim bakımından irdelemeyi amaçlar. Hikâyenin çözümlemesinde dil, üslup, yapı, kişiler, olaylar, ve diğer unsurlar üzerinde durulmuştur.
COMPARATIVE MORPHOMETRIC, MERISTIC AND OSTEOLOGICAL STUDIES ON ADULT AND YOUNG HILSA (TENUALOSA ILISHA)
Authors: Hosen Talukder Md. Monuar , Hoque Majedul , Ara Ismot
Published: December 2023

Tenualosa ilisha (matured/adult) and jatka (immature/young), locally known as Ilish, is designated as the national fish of Bangladesh. Both the stages were collected from different fish markets from Savar, Bangladesh during the exploration. This study was carried out on comparative morphometric, meristic and osteology between the Tenualosa ilisha (matured) and jatka (immature/young). The morphometric characteristics were higher in matured Tenualosa ilisha than immature jatka and among them head length, pre-dorsal length, postorbital length, the height of anal fin, eye diameter length, and abdominal region length were found significantly different. The proportion of standard length and snout length, head length and snout length, abdominal region length and standard length were significantly different between the two stages. Among the meristic characteristics; number of dorsal fin rays, anal fin rays and scales on the lateral line were found with little differences between matured hilsa and jatka. There are very small differences in the number of scales, scutes and fin rays of different fins between the two stages of fishes. The osteological comparison reveals more or less identical structure. Most of the bones of the skull were similar in structure but differed in size, shape and thickness.
FROM SPARROW TO EAGLE: AN IN-DEPTH ANALYSIS OF AVIFAUNA AT RIE BHOPAL CAMPUS
Authors: Aryaa Apeksha , Kumar Vishal
Published: December 2023

Birds are the indicator of a healthy ecosystem. Any ecosystem that houses diverse birds is sustainable, balanced and healthy. This concept ignited a curiosity to find out about our ecosystem through birds. In this order, authors embarked on a nine-month-long study, spanning from August 2022 to April 2023, to meticulously monitor the avian population within the campus of Regional Institute of Education (RIE), Bhopal, India. Throughout this duration, authors witnessed a captivating array of birds, including both resident and migratory species. The cumulative tally unveiled an impressive count of 67 distinct bird species. These findings led us to the resolute conclusion that the RIE Bhopal campus is endowed with remarkable richness and diversity. To uphold this magnificence, it becomes imperative to implement sustainable measures for its preservation and conservation.
Modular Bodies of Animated Characters and Posthumanist Connotations. Translation into Russian
Authors: Oktan Ahmet , Akyol Oktan Kevser , Çon Gülsüm Büşra
Published: December 2023

This article discusses the molecularization of the body and the meanings pointed out via cyborg bodies in the context of animated characters. We analyze films of Ghost in the Shell (Mamoru Oshii, 1995), Ghost in the Shell: SAC_2045- Sustainable War (Shinji Aramaki Michihito and Fujii Kenji Kamiyama, 2021), Gunnm (Hiroshi Fukutomi, 1993), and Alita: Battle Angel (Robert Rodriguez, 2019) in the context of related philosophical discussions. We carry out the discussion about the body on two axes. First, we examine forms of presenting the modular bodies and discuss their socio-cultural connections. In these narratives, the evolution of the body beyond organic boundaries transforms it into a space where the character reflects the subjectivity and a tool that offers a narcissistic experience of omnipotence regarding bodily strength and competence. However, it sometimes causes the characters to become alienated from their bodies and engage in existential inquiries. Thus, secondly, we examine the existential inquiries/crises of the characters arising from the modularization of their bodies and the philosophical connotations that these emphases indicate. If on this axis, posthumanist arguments that stand out with objections to Cartesian distinctions such as machine-human, mind-body, woman-man, and anthropocentric approaches constitute the focus of the discussions.
The Unpredictable Corporeal Topos. A Review of F. Bork Petersen's Book “Body Utopianism. Prosthetic Being Between Enhancement and Estrangement
Authors: Yakushenkova Olesya S
Published: December 2023

This is a review of Franziska Bork-Petersen's book “Body Utopianism. Prosthetic Being Between Enhancement and Estrangement”, which discusses the changes in corporeality and the use of various tools that have become an important part of contemporary culture. It explores the relationship between culture, the transformation of corporeality and our perception of these changes. The book offers an interesting perspective on the changing corporeality of the contemporary world and its socio-cultural implications.
UM ANDROID BASEADO EM BLOCKCHAIN
Authors: Pedrosa Priscila
Published: December 2023

Este artigo tem o objetivo de apresentar um experimento em direito e tecnologia e, a partir dele, refletir sobre como a arte pode ajudar transformar o direito a partir da organização autônoma do trabalho. Como fundamentação teórica utilizaremos o diálogo produtivo entre Miroslav Milovic e Antonio Negri. A compreensão deste experimento traz novas heurísticas e arquiteturas que ajudam a representar outras experiências de cooperação e remuneração, demonstrando o que o professor Milovic chamaria de “direito como potência”, uma maneira de reinventar o direito a partir de práticas imanentes. A problemática da discussão se dá em torno da busca por alternativas aos modelos de organização que conhecemos, desvelando que há muito mais formas de se organizar do que as que conhecemos e as que pretendemos regular com as categorias jurídicas existentes. No campo teórico, a discussão parte da hipótese negriana de que o trabalho constitutivo da potência produz o mundo, constrói novas instituições, produz novas normas e (re)estrutura poderes constituídos. O diálogo entre as teorias de Antonio Negri de poder constituinte, enquanto potência imanente da multidão que subverte estruturas existentes, com o pensamento de Miroslav Milovic e a potência autorreflexiva da diferença como condição para uma abertura do direito para uma vida autêntica nos darão a perspectiva para analisarmos o experimento Plantoid como essa potência imanente capaz de criar relações autênticas e criativas unindo arte, ciência e tecnologia para imaginar novas relações entre organização, direito e instituições. Apresentamos dois problemas: O que o experimento do Plantoid nos diz sobre reinvenção das relações sociais e do direito como potência transformadora? O que o experimento Plantoid subverte e constitui novos direitos?
PARA PENSAR UMA JURISPRUDÊNCIA DOS CORPOS
Authors: Corrêa Murilo Duarte Costa
Published: December 2023

Quando Miroslav Milovic escreveu Direito do simulacro (Milovic, 2022), o fez como um resumo e à guisa de encerramento de um curso que Miro ministrou, e que teve lugar na Universidade de Brasília. Este curso, em franco diálogo com a filosofia de Gilles Deleuze e Félix Guattari, tematizava um “direito da potência” – tema que talvez não soasse estranho se pensássemos em Espinosa e em seu desafio ao Direito Natural clássico (Deleuze, 2008a), mas que pensado junto a Deleuze e Guattari poderia parecer fora de lugar. Muitos estudiosos de Deleuze e Guattari talvez o ignorem, mas, com seu gesto, Miro prolongava sabiamente uma das trilhas que havia sido aberta por Félix Guattari (2022) nos seus années d’hiver: evitar manter sobre o direito uma concepção juridicista e estreita demais. Pensar o direito e a sua prática em sentidos cada vez mais ampliados, como um verdadeiro equipamento coletivo no coração do qual os grupos de usuários tensionam, recriam e subvertem instituições; assim, o direito poderia se transformar em uma verdadeira máquina de enunciação coletiva.
PRAVO NA TELO KOD NIČEA I FUKOA
Authors: Milovic Miroslav
Published: December 2023

Ovaj tekst analizira kritičke mogućnosti Ničeovog i Fukoovog razmišljanja koja proističu iz koncepta tela. Ako je za Ničea filozofija loše razumevanje tela, za Fukoa je mogućnost preispitivanja same subjektivnosti. Kroz ova čitanja je moguće razmišljati o pravu na telo kao ponovnom otkriću života.
КОНЦЕПТУАЛИЗАЦИЈА ЛЕКСЕМА ЂАВО И ВРАГ У СРПСКОМ ЈЕЗИКУ
Authors: M. Манојловић Кристина
Published: December 2023

The subject of the work is the conceptualization of the terms đavo and vrag in the modern Serbian language. The paper gives a brief overview of previous research on the theory of conceptual metaphor as a basic domain of interest in cognitive linguistics, with the aim of gaining insight into the problem of this theory, its clarification and application to extracted material. The conceptual domains that the lexemes đavo and vrag form in language were pointed out through the theory of conceptual metaphors. Discovering the semantic potential led to the observation of metaphors that structure the mentioned terms and participate in their conceptualization, which is the goal of this analysis. The material was excerpted and analyzed from the electronic corpus of the contemporary Serbian language (SrpKor). The most typical source domains that were determined: ENTITY, HUMAN, ANIMAL, OBJECT, MATTER, etc., helped in establishing conceptual metaphors that were constructed from more general to more concrete (THE DEVIL IS A LIVING BEING→THE DEVIL IS A HUMAN→THE DEVIL IS AN ALLY / MASTER TO WHOM WE SERVE / JUDGE, etc.)
СОЦИОЛИНГВИСТИЧКИ ПРИСТУП ГОВОРУ СЕЛА СТАЈКОВЦА
Authors: Г. Митић Анђела
Published: December 2023

The paper presents the results of sociolinguistic research on the speech of Stajkovce village. The speech of Stajkovce village belongs to the Prizren-South Moravian dialect. The goal is to present the representation of four most important dialectal features through gender, age and educational levels of speakers from the village of Stajkovce, in order to determine the status of the dialect among different speakers. The research was conducted with the help of recording the spontaneous speech of the respondents, in which participated sixteen speakers of different age, education and gender. All speakers were classified into four age groups, where respondents of both sexes were equally represented, and into three educational groups. Four dialectal features were observed. The transcribed and accented material was analyzed by quantitative analysis. Quantitative analysis resulted in frequency indices, frequency scales and diagrams. Based on the obtained values, a qualitative analysis was performed. The results show that the lowest preservation of dialect features in the separated age groups occurred in subjects aged 15 to 20 years, while the highest preservation of dialect features occurred in subjects aged 40 to 60 years. In addition, there are differences in the representation of dialect features among speakers of different genders within the same age groups. The group of speakers with primary school education had the lowest frequency indices, and the group of speakers with secondary school education had the highest indices. At the end, conclusions are offered about the threat of observed dialectic traits.
РАДНЕ БИОГРАФИЈЕ ПРЕДАВАЧА СРПСКОГ КАО СТРАНОГ ЈЕЗИКА НА ОНЛАЈН-ПЛАТФОРМИ ПРЕПЛИ
Authors: М. Новаковић Александар , Р. Јаћимовић Јована
Published: December 2023

The paper analyzes the work biographies of Serbian as a foreign language lecturers on the platform Preply, with the aim of creating a clearer picture of the qualifications they possess, but also of the ways in which they present themselves to potential students. For the purposes of the research, the observation method, the descriptive method and the theoretical analysis method with the content analysis technique were used. The material for this research consisted of a total of 67 work biographies. The analysis of the collected data showed that the role of teachers is played by professors of Serbian as a mother tongue and Serbian as a foreign language, then professors of foreign languages (Russian, English, Italian, Arabic, French and Spanish), professors of chemistry, music, medicine, mathematics, then economists, engineers , psychologists, handball players, tennis players, and even those who, apart from being native speakers of the Serbian language, have no special professional qualifications. In this connection, appropriate legalities were observed in the writing of work biographies and the design of their constituent parts.