bluuebunny/crossref_metadata_2025 huggingface dataset:
Participatory Varietal Selection and Agronomic Performance Evaluation of Kik-Type Field Pea Varieties in Guji zone, Southern Ethiopia
Authors: Deresa Shumi
Published: November 2023

Abstract: In the main cropping season of 2021, a field experiment was carried out in the Bore, Dama, and Anna Sora districts of the Guji Zone on stations and farmers’ fields. The experiment’s goal was to compare agronomic traits with farmer input to evaluate on-farm varieties, choose farmers’ favorite varieties, and then recommend the best performing varieties for the Guji Highland field pea production regions. At the Bore Agricultural Research Center, an on-station experiment was conducted utilizing RCBD with three replications. Ten enhanced kinds that were introduced both nationally and regionally were tested and chosen based on their desirable characteristics. From each district, two farmer’s fields were used, and the farmer’s fields were replicated. Farmers employed a variety of factors in addition to agronomic information, such as days to blooming, plant height, pods per plant, and seed per pod, to evaluate field pea varieties. Growth habits, production performance, disease and insect resistance, marketability, and diet compatibility were the main selection criteria used by farmers. The majority of farmers chose the Burkitu variety, followed by the Bamo variety, based on the selection criteria. The analysis of the agronomic data also showed that the selected varieties for the farmers were chosen for their high yielding and other assessed qualities. Bilalo had the highest seed yield (4167 kg/ha), followed by Bamo (3312 kg/ha), and Adi (3104 kg/ha), according to the results of the combined analysis.Due to its excellent grain output, appealing seed color, large seed size, and overall preferable field performance, the Burkitu variety was chosen. These findings suggested that farmers had a thorough understanding of how to choose and decide on the chosen better varieties in comparison to the inferior types. Keywords: Farmers’ Criteria: kik-Type: Participatory Selection: Ethiopia
ЛИСТ ШВЕДСЬКОГО КАНЦЛЕРА КАРЛА ПІПЕРА ДО ПОЛЬСЬКОГО КОРОЛЯ СТАНІСЛАВА ЛЕЩИНСЬКОГО ПРО І. МАЗЕПУ від 21 вересня 1705 р.
Authors: Павленко Сергій , Мешковой Максим
Published: November 2023

У публікації вперше представлений переклад українською мовою листа шведського канцлера К. Піпера до польського короля С. Лещинського. У ньому високопосадовець Карла ХІІ дає від імені свого короля згоду надати гарантію гетьману І. Мазепі та його однодумцям, а також захист, опіку, в разі, якщо вони підтвердять своє бажання позбутися залежності від Москви.
«ДА НЕ ЗАЙДЕТЬ СОЛНЦЕ ВЪ ГНѢВЕ ВАШЕМ…»: ВІЗІЯ ГНІВУ В КИЄВО-ПЕЧЕРСЬКОМУ ПАТЕРИКУ
Authors: Петрушко Людмила
Published: November 2023

Метою статті є комплексний аналіз візії гніву, притаманної печерській емоційній спільноті та відображеної у тексті Києво-Печерського патерика. Методологія дослідження полягає в застосуванні методів аналізу, синтезу та узагальнення, класифікації та систематизації, індукції та дедукції, наративного, ретроспективного, історико-порівняльного, історико-хронологічного, історикосистемного, термінологічного аналізу, інтерпретаційного, контент-аналізу та методів історії емоцій. Наукова новизна. У статті здійснено першу спробу комплексного аналізу зафіксованої у тексті Києво-Печерського патерика візії гніву печерської спільноти. Висновки. Встановлено 4 актуальні обставини прояву гніву: дії без волі / всупереч волі носія влади (князів, батьків), образа, гріховність, невиправдання очікувань. Повідомлення про гнів засвідчують такі неістинні для печерської спільноти цінності, як власна воля, честь особиста або роду, узгодження дій із волею князя; а також правильний для печерян ідеал святості та благочестя. Як правильний сприймався, очевидно, гнів через гріх та беззаконня. У більшості випадків цей емоційний стан негативно сприймався печерською спільнотою, що узгоджується із християнською традицією. Гнів спричиняли пристрасті егоїзму, марнославства, честолюбства тощо. Він призводив до негативних наслідків. Особливо засуджувалося тривале перебування в гніві, а також священницьке служіння й причащання Святих Дарів у такому негідному стані. В уявленні людини українського Середньовіччя гнів, напевно, був прерогативою Бога. Єдино дозволеним людським гнівом визнавався гнів на гріх. Гнівні емоції співвідносилися з носіями влади, представниками вищих прошарків соціуму. Хоча нерідко гнів пов’язується із ворогами спасіння, вирішальною все ж визнається воля людини. Ліки проти нього – смирення (земний поклон, прохання про прощення).
Сергій Плохій. Брама Європи. Історія України від скіфських воєн до незалежності / Пер. з англ. Романа Клочка. – Переробл. і доп. вид. Харків: Книжковий Клуб «Клуб Сімейного Дозвілля», 2023. 512 с.
Authors: Гордієнко Дмитро
Published: November 2023

Український переклад нарису історії України «Брама Європи» професора Гарвардського університету, емігранта з України Сергія Плохія витримав низку видань в Україні, що незвично для сучасного українського книговидання, навіть в історичній тематиці. Первісно книга була написана й опублікована англійською мовою (Нью­Йорк, 2015) і призначалася для англомовного читача. Для українського історика вітчизняне видання книги С. Плохія цікаве з погляду того, що на Заході широкому загалу відомим є лише мінімум інформації з історії України, адже очевидно, що англійський переклад багатотомної академічної «Історії України­Руси» Михайла Грушевського потрапить у поле зору переважно невеликого кола науковців. Для українського ж загалу маємо ще один добрий та оригінальний синтез української минувшини. Структурно книга складається з 5 розділів, виділених за цивілізаційним та політичним критеріями.
ПОЛІТВІДДІЛИ МТС – КРЕМЛІВСЬКА ОКУПАЦІЙНА АДМІНІСТРАЦІЯ 1933–1934 рр. НА ПІВДНІ ЧЕРНІГІВЩИНИ
Authors: Еткіна Ірина
Published: November 2023

Метою статті є викриття ролі політвідділів МТС півдня Чернігівщини у виконанні злочинних наказів Сталіна та його оточення у 1933–1934 рр., що посилило трагедію Голодомору-геноциду в цьому краї та репресії проти свідомих українців.   Для цієї розвідки використано методологічний підхід «історії знизу» або загальнонауковий метод індукції, що дозволяє на основі аналізу великого масиву архівних джерел, які характеризують як роботу працівників політвідділів МТС, так і становище місцевого населення, робити загальні висновки. Наукова новизна розвідки полягає в тому, що проблема політвідділів МТС на матеріалах Чернігівщини не досліджена, на теренах України також не знайшла системного вивчення, незважаючи на велику увагу до тематики Голодомору в цілому.   Опрацьовані матеріали дозволили дійти таких висновків. На матеріалах Чернігівщини доведено, що працівники цих органів влади безпосередньо впроваджували злочинні накази Кремля на місцях у 1933–1934 рр., що призвело як до масових смертей селянства внаслідок голоду, так і до масових репресій тих, хто асоціювався для Сталіна з «петлюрівщиною», отже, до свідомих українців різних прошарків села. Проаналізовано фахові та морально-етичні якості кадрів політвідділів. Зроблено висновок про низький рівень освіти та культури працівників політвідділів МТС, відсутність моральних цінностей, підміну їх більшовицькою ідеологією, брак співчуття до жертв голодомору та репресій.
З ІСТОРІЇ ЖИТТЄВОГО ШЛЯХУ ЮРІЯ АНАТОЛІЙОВИЧА ПІНЧУКА (до 85-річчя від дня народження)
Authors: Дорохіна Тамара , Кахерський Юрій
Published: November 2023

Стаття присвячена видатному історику, історіографові, джерелознавцю ХХ–ХХІ ст. Ю.А. Пінчуку. Матеріал був підготовлений у 2022 р. до ювілею від дня народження науковця, проте з об’єктивних причин видання стало можливим у 2023 р. Мета статті – висвітлити основні етапи життєвого та творчого шляху Ю.А. Пінчука, вибір головної теми наукового дослідження, ініціативи вченого, пов’язані з увіковіченням пам’яті М.І. Костомарова. У статті приділено увагу професійній діяльності Ю.А. Пінчука в наукових установах, наставницькій роботі та популяризації української історіографії, виголошено основні студії, яким вчений присвятив своє життя. Методологічна основа роботи ґрунтується на базі біографічного методу, з використанням принципів історизму, об’єктивності, науковості та системності, що забезпечили комплексне дослідження проблеми. Висновки. Представлено значення наукової діяльності Ю.А. Пінчука загалом, його наукового доробку в контексті означеної проблематики – костомаровознавства, а також організаторської та навчально-просвітницької діяльності.
НЕНАУКОВІ ХРОНІКИ ВІЙНИ: ЖІНОЧИЙ ЕСТЕЗИС. 77 днів лютого. Україна між двома символічними датами російської ідеології війни / Упорядник М. Паплаускайте. Київ: Лабораторія, 2022. 224 с.
Authors: Каранда Марина
Published: November 2023

Це книга репортажів, написаних журналістками українського видання Reporters про гострий період війни між 24 лютого та 9 травня 2022 р. Опублікована вона у серпні 2022 р. Рік по тому книга не перестає бути актуальним свідченням масштабної трагедії, яка спіткала мільйони українців.
ГРАНТОВА ПРОЄКТНА ДІЯЛЬНІСТЬ ФАКУЛЬТЕТУ ДОШКІЛЬНОЇ, ПОЧАТКОВОЇ ОСВІТИ І МИСТЕЦТВ НАЦІОНАЛЬНОГО УНІВЕРСИТЕТУ «ЧЕРНІГІВСЬКИЙ КОЛЕГІУМ» ІМЕНІ Т. Г. ШЕВЧЕНКА ЯК ШЛЯХ ДО МІЖНАРОДНОГО ПАРТНЕРСТВА
Authors: Стрілець Світлана , Шпеко Анна
Published: November 2023

Мета статті – висвітлення грантової проєктної діяльності факультету дошкільної, початкової освіти і мистецтв Національного університету «Чернігівський колегіум» імені Т. Г. Шевченка як шляху до міжнародного партнерства у галузі освіти та науки.
Методологія. Для досягнення мети дослідження використано комплекс методів: теоретичні (аналіз і синтез нормативно-правових документів, наукових праць україн-ських дослідників, узагальнення та систематизація для структурування результатів дослідження та формулювання висновків) та емпіричні (спостереження та бесіда для відтворення перебігу реалізації грантових проєктів). 
Наукова новизна. У статті розкрито перебіг та результати участі науково-педагогічних працівників факультету дошкільної, початкової освіти і мистецтв Національного університету «Чернігівський колегіум» імені Т. Г. Шевченка у міжнародних грантових проєктах «Розвиток культури демократії в педагогічній освіті в Україні, Норвегії та Палестині» та «Підтримка демократії в освітній системі України під час війни»; показано, що грантова проєктна діяльність є шляхом до міжнародного партнерства у галузі освіти та науки.
Висновки. Реалізація грантових освітніх проєктів на факультеті дошкільної, початкової освіти і мистецтв Національного університету «Чернігівський колегіум» імені Т. Г. Шевченка доводить, що важливу роль у системному розширенні міжнародних науково-педагогічних контактів відіграє взаємодія з міжнародними організаціями, фондами і програмами у галузі освіти та науки. З огляду на кількарічний досвід, уважаємо, що ефективними формами міжнародного партнерства закладів вищої освіти мають стати: двосторонні та багатосторонні програми обміну між університетами; навчальні та наукові стажування; спільні заходи – міжнародні наукові конференції, наукові дослідження, проєкти, спрямовані на підвищення якості вищої освіти; професійна підготовка, перепідготовка та підвищення кваліфікації іноземних громадян за різними спеціальностями та програмами.
Viuria Grishin, 2019 (Lepidoptera: Hesperiidae): taxonomy, description of two new species, and remarks on the morphology of secondary sexual organs of males
Authors: Siewert Ricardo Russo , Lemes José Ricardo Assmann , Mielke Olaf Hermann Hendrik , Casagrande Mirna Martins
Published: November 2023

The taxonomy of the Neotropical Carcharodini genus Viuria Grishin, 2019 (Lepidoptera: Hesperiidae: Pyrginae) is presented. Two new species are described: Viuria inanna sp. nov. from south-southeastern habitats Brazil and Paraguay, and Viuria acadia sp. nov. from Brazil and Ecuador. Illustrations of adults, including morphology of secondary sexual organs in males, male and female genitalia, diagnoses, remarks, and updated geographical distributions are also provided for all species.
REFLEXIONES por CRISTINA TANIA FRIDMAN MEDALLA DE ORO DE WAS 2023 ASOCIACIÓN MUNDIAL PARA LA SALUD SEXUAL
Authors: FRIDMAN CRISTINA
Published: November 2023

CRISTINA TANIA FRIDMAN MEDALLA DE ORO DE    WAS 2023
A Procuradoria-Geral do Banco Central e a Sustentação Jurídica da Estabilidade das Políticas Monetárias
Authors: Strätz Murilo
Published: November 2023

Abordam-se os aspectos teóricos e legais do instituto da segurança jurídica, bem como a sua relação com a autonomia do Banco Central do Brasil (BCB) e a independência técnico-jurídica dos membros da Procuradoria-Geral do Banco Central do Brasil (PGBC), na contribuição que prestam para a estabilidade monetária e a segurança jurídico-econômica. Disseca-se o protoprincípio da segurança jurídica, a partir de suas classificações doutrinárias, na tentativa de demonstrar que as atribuições da PGBC se voltam a conferir calculabilidade e previsibilidade às expectativas jurídicas legitimamente depositadas pelos agentes financeiros e pela população em geral na execução da política monetária a cargo do BCB.
Preparation and anti-amyloid aggregation activity of curcumin loaded hydrocolloid films
Authors:   , Kanana Nattakan
Published: November 2023

Cur film was fabricated using 0.2% of curcumin, 3% of HPMC and 1% of PVP and characterized their physical and chemical properties. The FE-SEM micrographs, FTIR, DSC and TGA data confirmed the presence of curcumin and intermolecular interaction between curcumin and film-forming polymers. In addition, cur film possessed better pH stability than curcumin. Interestingly, the water solubility of curcumin in the cur film was 3.1 μg/mL which higher than that of curcumin approximately 2.8x10³ times. The shelf-life stability of cur film was evaluated at the interval times, 0, 15, 30, 60, 90 and 120 days by keeping in transparent and opaque sealed-bags at ambient temperature. It is found that curcumin amount, FTIR and TGA data do not showed the degradation of active compounds and are not significantly different between both storage conditions. However, the water solubility and pH stability slightly reduced as a function of storage time.
Preparation of chitosan beads containing and control releasing of saponin against golden apple snail Pomacea canaliculata
Authors:   , Khumsup Phetrada
Published: November 2023

Chitosan beads have been prepared to contain and control the release of saponin which used to against golden apple snails.  The morphology of chitosan beads were characterized by FTIR and SEM. The formation of chitosan beads have a regular spherical shape with regular size prepared by using 2% w/v of chitosan solution with mixed solution of 10%w/v sodium hydroxide, 1% w/v of sodium tripolyphosphated and 50% v/v of ethyl alcohol. Ten percentage of saponin (w/w) was loaded into chitosan matrix found that higher amount of saponin was released when compared with loading of 1% saponin (w/w). Furthermore, mixed tea seed meal in chitosan matrix with ratio of 1:3 w/w affected beads properties such as bigger bead sizes, rough surface and more water swelling that enhanced the amount of saponin release when compared with natural chitosan beads. Release behavior of saponin were studied in deionize water and calcium chloride solution, it was found that more release of saponin in deionized water. Moreover, toxic testing of saponin with other living animals in agriculture such as Nile Tilapia fish and Pomacea Canaliculata snails showed LC50 values of saponin to Nile Tilapia fish and P. Canaliculata snails were 2.13 ppm in 72 hours and 7.45 ppm in 96 hours. In addition, rice that treated saponin with concenetration of 10-50 ppm had been increase growing and high productivity. Summary it can be conclude that the mixture of chitosan and tea seed meal beads containing saponin have a potential to develop as molluscicide against golden apple snails with friendly environment.
Surface modification of ZnSe/ZnS Quantum dots with biocompatible polymer for biological applications
Authors:   , Palikanon Radawan
Published: November 2023

In this work, ZnSe/ZnS quantum dot nanoparticles (ZnSe/ZnS QDs) were synthesized and modified in order to apply in bio-application. ZnSe/ZnS QDs were synthesized using zinc stearate as zinc precursor and 1-octadecene as solvent by a hot-injection method in one-pot. The ZnSe/ZnS QDs were characterized using UV-visible spectroscopy, fluorescence spectroscopy and TEM. The photoluminescence of ZnSe/ZnS QDs was blue with the emission wavelength of about 400-450 nm and narrow full width at half maximum (FWHM) of about 20-30 nm. For TEM images, the results showed size and structure of ZnSe/ZnS QD nanoparticles. The average diameter of ZnSe/ZnS QDs particles was 3.8±0.4 nm. The size of ZnSe core QDs was increased upon coating with ZnS shell. In order to improve dispersibility in aqueous phase and reduce toxicity, ZnSe/ZnS QDs were modified with thiol-conjugated polyamidoamine (PAMAM) polymer by ligand exchange method. The results showed that ZnSe/ZnS QDs 4-(3,5-bis(mercaptomethyl)phenoxy)butanoic acid poly(amidoamine) (ZnSe/ZnS QDs-BMPBA-PAMAM) were obtained with higher efficiency than ZnSe/ZnS quantum dots dihydrolipoic acid poly(amidoamine) (ZnSe/ZnS QDs-DHLA-PAMAM). For cytotoxicity studied by methylthiazolyldiphenyltetrazolium bromide (MTT) assay, ZnSe/ZnS QDs were studied in comparison with the conventional CdSe/ZnS core-shell QDs. The Zn-based QDs exhibited lower toxicity than the Cd-based QDs, and the QDs that have been modified with thiol-conjugated PAMAM polymer showed higher biocompatibility than the ones without PAMAM and be more suitable for applying in biological applications.
Effects of preparation methods on activity of Ni/SiO2 fiber catalysts in ethanol steam reforming
Authors:   , Mhadmhan Sareena
Published: November 2023

The purpose of this research was to study the effects of preparation methods on Ni/SiO2 fiber catalyst for apply to investigate catalytic activity for hydrogen production in ethanol steam reforming (ESR). The catalysts were prepared by three different methods: impregnation (IM), deposition precipitation (DP) and strong electrostatic adsorption (SEA). Silica fiber (SF) supported nickel catalyst have been synthesized by using a combination of a sol-gel method and electrospinning technique. The prepared catalysts were characterized by BET, H2-TPR, XRD, SEM-EDX, TEM and TGA technique. The catalytic tests were performed at atmospheric pressure by using the steam/ethanol mole ratio of 9 and the space time of 18 gcatalyst·h/molethanol between 400 and 600°C. According to the results, the preparation method had a strong affect on catalytic performance of Ni/SiO2 fiber catalysts used in the ethanol steam reforming. The fiber catalyst prepared by strong electrostatic adsorption method was smaller NiO particle size and stronger metal-support interaction than deposition precipitation and impregnation methods. The NiO particle size in the nickel supported on silica fiber catalyst ranged from 7 nm to 22 nm. The highest catalytic activity was Ni/SF-SEA and their catalytic activity were ordered by Ni/SF-SEA > Ni/SF-DP > Ni/ SF-IM > Ni/SP-IM. The different catalytic activities were related to the particle size and metal-support interaction.
INVESTIGATION OF WELL PLAN PARAMETERS FOR DIRECTIONAL DRILLING IN GULF OF THAILAND
Authors:   , Hentoog Anusara
Published: November 2023

Directional drilling is commonly practiced in complex structure reservoir in Gulf of Thailand. Directional well path is planned by different well planner experiences. Torque and drag analysis are performed to examine drillability of well path. This process may take time and effort. This study provides optimum sets of well plan parameters i.e. kick off point (KOP), inclination (INC), build rate (BUR) based on torque and drag as criterion, to improve well planning process. This study is based on 4 well profiles; 2 dimensional (2D) build and hold, 2D build hold and drop, 3D build and hold and 3D build hold and drop. Each well profile requires different well plan parameters. To allow efficiency of well plan parameters varying process, a set of fundamental well construction and reservoir data are assumed. Constrain values are based on Gulf of Thailand field data. Derivative torque and drag from each well profile are observed, analyzed and evaluated. The effect of mud weight also investigates in this study. The study found that KOP and INC are the most important well plan parameters on torque and drag generated in deviated wells. Other well plan parameters show minor effect. 2 deg./100ft. BUR generates significantly low torque and drag in build section. However, there is a limit to apply. Varied mud weight afftects torque and drag as increase 1 pound per gallon of mud weight yields lower torque and drag as 1.5 percent approximatly. The parameters set and limit of well plan parameters for each well profiles are presented in this paper.
Effects of Polymer Adsorption and Desorption on Polymer Flooding in Waterflooded Reservoir
Authors:   , Sapniwat Sukruthai
Published: November 2023

Polymer Flooding is one of the most well-known methods in Enhanced Oil Recovery (EOR) technology which can be implemented after either primary or secondary recovery. Polymer can lower the mobility ratio of the displacement mechanism by means of increasing viscosity of injected water. Therefore, polymer flooding can increase volumetric sweep efficiency. Moreover, polymer adsorption onto rock surface can decrease permeability contrast in reservoir with high heterogeneity. Due to reduction of the absolute permeability, effective permeability to water is also reduced. Once polymer is adsorbed onto rock surface, polymer can also be desorbed when different fluids are injected. This study focuses on polymer adsorption/desorption behavior in the reservoir as well as effects on operating parameters and interest reservoir conditions. Reservoir simulator called STARS® commercialized by Computer Modeling Group is utilized to assess interest effects. The results show that performing polymer flooding after water pre-injection sooner can increase oil recovery factor in the shortest period and similar results are also obtained from higher injection rate. The difference of polymer mass injected into the reservoir, represented by polymer concentration affects the optimum polymer slug size. Higher polymer concentration requires smaller slug size of polymer to attain constant oil recovery factor, vice versa. Polymer desorption causes polymer re-employment from the previously adsorbed onto rock surface, resulting in improving of sweep efficiency in the further period of polymer flooding process. However, the optimum value of polymer desorption degree in difference polymer concentration exists. When using high polymer concentration, total polymer desorption allows chasing water to bypass polymer slug, causing adverse effect on sweep efficiency. In reservoir with variation in permeability, polymer can be injected to retard early water breakthrough. However, degree of polymer desorption should be zero to allow permanent adsorption as reduction of relative permeability to water can be maintained to ensure slow movement of inject fluid. Magnitude of polymer adsorption does not affect much on oil recovery factor when degree of polymer desorption is varied. In high magnitude of polymer adsorption, zero polymer desorption causes less effective polymer to maintain viscosity whereas effects of reduction of relative permeability dominates effects of maintaining viscosity in case of 50 percent polymer desorption. Combination of total desorption with high residual resistant factor shows favorable results. Sweep efficiency is improved also at boarder of flood pattern and moreover, diverting of chasing water to border zones results in very favorable sweep efficiency.
PHARMACOKINETIC/PHARMACODYNAMIC STUDY OF VORICONAZOLE FOR INVASIVE ASPERGILLOSIS TREATMENT IN THAI ADULT PATIENTS
Authors:   , Tantasawat Montira
Published: November 2023

An azole antifungal , voriconazole (VRZ), exhibits nonlinear pharmacokinetics (PK) due to saturated metabolism and several factors influence its PK. Currently, PK parameters of VRZ in adult Thai patients have not been identified, which causes uncertainty in VRZ level estimation. This study aimed to determine the VRZ PK parameters for adult Thai patients, factors influencing these parameters and the association between the VRZ concentration and clinical outcome in invasive aspergillosis (IA) treatment. Medical records of eligible patients at Ramathibodi Hospital during January 2013 and March 2016 were retrospectively reviewed. Of all 53 patients including in pharmacokinetic study, the median Km of were 0.26 mg/L and 0.67 mg/L for CYP2C19 EM and non-EM, respectively (p = 0.008). The Vmax of voriconazole were not different between each CYP2C19 phenotype (0.43 vs. 0.48 mg/kg/h for CYP2C19 EM and non-EM, respectively). Other than CYP2C19 phenotype, age, TB, and ALP were the significant factors influencing the Km, while none of patient’s factors could predict Vmax. Among eighty-one patients who were eligible for clinical outcome assessment, overall treatment success rate was 76.5 % and hepatotoxicity rate was 13.6%. The treatment success rate at VRZ Ctr of 3-4 mg/L was more than 90%. When compare to lower Ctr level, the hepatotoxicity rate was dramatically increased with VRZ Ctr of more than 5 mg/L. This study provided Km and Vmax of VRZ for Thai adult patients with IA, however their wide range indicated the high variability between individuals. Therefore, the need to start VRZ treatment with the recommended doses followed by therapeutic drug monitoring was warranted. Recommended VRZ Ctr for IA treatment for Thai adult patients was 3-4 mg/L because of its high treatment success rate together with avoiding drug-induced hepatotoxicity.
Comparative pharmacokinetic study of asiaticoside and madecassoside as the pure compounds and mixture in the standardized extract of centella asiatica, ECa 233 in rats
Authors:   , Hengjumrut Patcharaporn
Published: November 2023

ECa 233, the standardized extract of Centella asiatica, contains not less than 80% triterpenoid glycosides, in a madecassoside:asiaticoside ratio of 1.5 (± 0.5): 1. In this study, we performed a pharmacokinetic comparison of madecassoside and asiaticoside following intravenous and oral administration of ECa 233, or an equivalent dose of the individual compounds, in rats. Blood, tissues, urine and feces were collected after dosing for the determination of drug and metabolite levels using liquid chromatography-tandem mass spectrometry. The results revealed that plasma levels of madecassoside, and to a lesser extent asiaticoside, were higher after administration of ECa 233 than the corresponding values for the pure compounds. The elimination half-life of madecassoside and asiaticoside were significantly prolonged after administration of ECa 233 (p < 0.05). The mean resident time of asiaticoside appeared to be prolonged following the oral administration of ECa 233 compared with following administration of the pure asiaticoside (12.79 vs 7.20 h). Interestingly, there was a bidirectional interconversion between asiaticoside and madecassoside consistent with the increased exposure of madecassoside and asiaticoside in ECa 233.  In tissue distribution studies, asiaticoside and madecassoside appeared to be widely distributed in several organs. Both madecassoside and asiaticoside were metabolized extensively; following intravenous administration of either compound, approximately 80-90% of the dose was recovered as madecasssic acid and asiatic acid in the feces.
Effects of vanillin on cancer stem-like phenotypes in non-small cell lung cancer through the inhibition of Akt pathway
Authors:   , Srinual Songpol
Published: November 2023

Metastasis of cancer and failure of current treatment is mostly caused by cancer stem cells (CSCs) which is a minor population within whole tumor. CSCs lead to cancer relapse and chemotherapeutic resistance especially in lung cancer. Previous study reported that protein kinase B (Akt) and its signaling pathways govern both protein signalings and the CSCs phenotypes. Hence, Akt and its molecular pathway become promising target for the development of anticancer drug. However, the study regarding on the negative effect of natural compound on CSCs in cancer have been less discovered. Vanillin, the natural compound from Vanilla planifolia, posed attractive pharmacological activities which have been recently found to suppress cancer metastasis. Hence, the effects of vanillin on CSCs have not been previously studied. This study aimed to investigate the effects of vanillin on cancer stem-like phenotypes and related signaling pathway in non-small cell lung cancer H460 cells. The results indicated that non-toxic concentration of vanillin suppresses CSC markers, CSC behaviors and related transcription factors significantly. Focusing on the underlying mechanism, vanillin inhibits Akt activation through a down-regulation of Akt. Interestingly, the decrease of Akt level is caused by vanillin- enhancing Akt degradation via ubiquitin-proteasomal pathway. This finding provides a promising biological activity of vanillin against CSCs which might be benefit for anticancer drug development.
Development of a health literacy questionnaire for predicting non-specific neck pain in office worker
Authors:   , Areerak Kantheera
Published: November 2023

The objective of this thesis was to develop a health literacy questionnaire for predicting non-specific neck pain in office workers. This thesis was divided into four stages: 1) systematic review of randomized control trials to gain insights into the effectiveness of education on the prevention and cure of non-specific neck and low back pain and to identify effective educational content to prevent and treat non-specific neck and low back pain; 2) the development of neck pain-specific health literacy questionnaire; 3) evaluation of the predictive validity of the neck pain-specific health literacy questionnaire; and 4) evaluation of the ability of neck pain-specific health literacy questionnaire to predict duration of recovery from non-specific neck pain in office workers.

The results showed that the education programs were not effective in preventing and treating neck pain as well as treating low back pain. Three education topics that may be effective in the prevention and treatment of neck and low back pain were identified, namely, function of the spine, information on activities, and information on coping with the problems. The neck pain-specific health literacy questionnaire comprised six questions, with total score ranging from 0 to 24. The questionnaire had acceptable psychometric properties and can differentiate between office workers with and without non-specific neck pain. The questionnaire had acceptable ability to predict incident non-specific neck pain, but was unable to predict duration of recovery from non-specific neck pain in office workers.
Effects of the turning point markers and verbal instructions on the timed up and go test in typical children
Authors:   , Bustam Ika
Published: November 2023

This study investigated the effects of the turning point markers (line, cone, and picture) and verbal instructions (non-qualitative and qualitative) on the Timed Up and Go (TUG) test in typical children aged 6 to 12 years. Two hundred and ten typical children (105 boy and 105 girls) participated in this study. They were divided into seven groups according their age. All participants were asked to randomly perform TUG test in 6 conditions (3 turning point markers × 2 verbal instructions). The results showed that the reduction of time spent performing TUG test was found in every age group when applied a picture and qualitative verbal instruction the test (p<0.05).  Time spent performing the TUG test was vary on age, turning point markers, and verbal instructions. However, there was nonlinear reduction of time spent performing TUG test with increasing age in whatever conditions.  The time was found the shortest in 12 years old children and the longest in 6 years old children. The results of this study revealed that the outcome of TUG test was significantly influenced by age, verbal instructions and turning point markers in typical children. Therefore, the use of TUG test in typical children should be considered about the selection of the same turning point markers, and verbal instructions in order to compare the TUG outcomes both between pre- and post-test and between age groups.
Effects of elastic therapeutic taping and lower extremity stretching on heel pain, foot disability, and ground reaction force in individuals with plantar fasciitis
Authors:   , Pinarattana Sulithep
Published: November 2023

The objective of this study was to compare the effects of three interventions in individuals with chronic plantar fasciitis. A total of 30 subjects were randomly divided into three groups with 10 subjects per group. The first group received a 4-day elastic therapeutic taping, the second group received a 7-day lower-extremity stretching exercise, and the other group received both elastic therapeutic taping and stretching protocols.  Outcomes including pain intensity, foot disability, ground reaction force, and range of motion were collected at baseline, the end of the first visit, and 1-week follow up.

The results of immediate effects revealed that all groups significantly decreased current pain (p<0.05). The results of short-term effects also found that all groups significantly reduced current pain (p<0.05). The combined treatment group also demonstrated a decrease in foot disability (p<0.05). However, there was no significant difference in change of all variables among three groups. The current taping application could relieve heel pain because it supported plantar fascia during weight bearing activities, so the fascia overstretching and repeated injury could be inhibited.  Stretching of plantar fascia, gastrocnemius, peronei, and hamstring muscles could reduce foot disability because such exercise could unload pressure on the fascia, and prevent foot overpronation during walking. Thus, the combination between taping and lower-extremity stretching may be recommended when treating plantar fasciitis for better outcome.
MULTIFACETED HEALTHY COACHING PROGRAM IMPROVE HbA1c AND QUALITY OF LIFE IN OLDER ADULT AND ELDERLY WITH DIABETES MELLITUS TYPE 2 : SEMI-URBAN DWELLER BANGKOK THAILAND
Authors:   , Junkhaw Tiwaporn
Published: November 2023

Currently, prevalence of diabetes is risen. The variety strategies of prevention and control, commonly held view is that multi-approached interventions are more effective approach in improving glycated hemoglobin (HbA1c) controlling and influencing quality of life. The aim of this study was to evaluate the effect of the Multifaceted Healthy Coaching Program to improve HbA1c and quality of life among older adult and elderly type 2 diabetics semi-urban dweller, Bangkok, Thailand. A randomized control trial was performed 2 phases and involved 274 T2DMt in phase I and randomized 40 uncontrollable to receive the DM management booklet, diary records for healthy behaviors group education, short message (SMS) reminder for healthy behaviors and drug adherence and individual telephone counselling monthly. Statistical analysis were used paired t-test and independent t-test. Changing in fasting plasma glucose (FPG) from baseline, 3 and 6 months were applied Repeated ANOVA measurement. The situation highlight reported uncontrollable T2DM and low-moderate quality of life. Additional, almost of them were majority female (70.1%) with the average of aged over 60 year, over normal BMI (85.4%) and 90.5% having comorbidity. At 6 month were a significant improvement of health literacy, knowledge of diabetes, self-efficacy, self-care activity, HbA1c and quality of life (p<0.01) in the intervention group when compared to the control group (P<0.01). The Multifaceted Healthy Coaching was an acceptable intervention in their ongoing care. It appears to lead a significant benefits for limited of health literacy with poorly controlled type 2 diabetes.
EFFECT OF USING SMARTPHONE BEFORE BED ON SLEEP QUALITY AMONG UNDERGRADUATE STUDENT AT CHULALONGLONG UNIVERSITY BANGKOK THAILAND
Authors:   , Bunyalug Mookrawee
Published: November 2023

Introduction: People perform better when they have a good sleep but the smartphone usage is the one activity that people do before bedtime which can interrupt their sleep. So, this study aimed to describe the association between using smartphone before bedtime and sleep quality of undergrad student of Chulalongkorn University. Methodology: This is the cross-sectional study. The sample size is 423 students, both male and female. There are 4 sections of the questionnaire; 1) General Information and Covariate factors, 2) Stress, 3) Smartphone Use Behavior and Mobile Phone Problematic Use Scale and 4) Sleep Quality (PSQI). Collecting the data by self-report. The descriptive statistic and Chi-square were used to analyze the data. Result: The study shows 96.9% of the participants use the smartphone before bedtime, besides 90.8% of the use it in bed. The Mobile Phone Problematic Use Scale (MPPUS) with the sleep quality is in poor level with 63.5%. The General Information (age and monthly allowance), covariate factor (caffeine drink and stress) and smartphone use in bed are significantly associated with sleep quality also in significant association with sleep quality (p < 0.003) Discussion: Overall, all the result has showed some gap that the participant is lack of concern about the smartphone use before bedtime with the sleep quality, the raising of smartphone use it not only rise among undergraduate student, but in every age group. Therefore, this problem should be solved by creating a campaign to educate the people, so that they can be aware of.
Sleep quality and migraine among undergraduate students in Chulalongkorn University
Authors:   , Muanprasong Sirilak
Published: November 2023

Background: Migraine is a specific chronic headache which involved sleep process and chronobiologic patterns in regulation of sleep and headache. Therefore, current study investigated whether migraine headache could affect sleep quality among undergraduate students. Methods: A cross-sectional study was used to study the undergraduate students at a large public university in Bangkok, Thailand (N=317). A self-administer questionnaire was ascertained general demographics. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep habits and quality. The criteria established by The International Headache Society (ICHD-II) were used to assess migraine status. Chi-square tests and multivariate logistic regression models were used to identify statistically significant associations. Results: Sleep quality components were not statistically associated with migraine status among undergraduate students. With those not statistical association, poor sleep quality was tended to increase a 1.299 times risk of migraine (AOR = 1.299; 95% CI 0.329-5.131). Less sleep duration than 6 hours was suggested to increase 1.35-fold odds of migraine students (AOR =1.352; 95% CI 0.519-3.523). Longer sleep latency than 15 min had a 1.277-fold increased odds of migraine (AOR =1.277; 95% CI 0.523-3.116) although statistical significant was not achieved. Conclusion: Migraineur students had more poor sleep than non-migraineur students but not significant. These findings emphasize the requirement to educate students on the importance of sleep and policy makers to take action to improve the quality of headache care and access to treatment in Chulalongkorn university.
INFLUENCES ON THE UTILIZATION OF ANTENATAL CARE SERVICES AMONG REPRODUCTIVE AGE GROUP WOMEN IN MID-WESTERN DEVELOPMENT REGION OF NEPAL: A POPULATION BASED STUDY USING THE NEPAL MULTIPLE INDICATOR CLUSTER SURVEY(MICS) 2014.
Authors:   , Adhikari Suman
Published: November 2023

The antenatal care (ANC) provides an opportunity for health information and services that can significantly enhance the health of women and their babies. Nepal has shown a significant progress in improving maternal health. However, maternal mortality rate (MMR) still remains high mostly in Mid-Western region in Nepal in comparison to other regions. This study aimed to explore the influencing factors associated with utilization of ANC. This study uses the data taken from the Multiple Indicator Cluster Survey (MICS) conducted in Nepal by the Ministry of Health and Population with a technical support from UNICEF. The analysis was conducted on 322 women who gave live birth in last two years preceding the survey. Bivariate and multivariate logistic regression analysis was carried out to identify influencing factors associated with ANC utilizations. Seventy-nine percent women attended ANC visits. Out of them only fifty-four percent women attended complete (four or more) ANC visits. Studies finds following factors affecting antenatal care utilization: Maternal age, education, wealth index, listening to radio and watching television. The following factors influences complete (four or more visits) antenatal care utilization: Education, Sub-region, wealth index and watching television. Overall ANC utilization was 79.8%. Frequency of antenatal care visits is not satisfactory in this region. Out of 257 who received ANC care, only 54% women received complete ANC (four or more visits). Maternal age, education and wealth index had prominent effect on utilization of ANC service. Parity, husband’s education and residence had no effect on the utilization of antenatal care visits in this study
FACTORS ASSOCIATED WITH DIARRHEA AMONG CHILDREN LESS THAN 5 YEARS OLD IN SUDAN: A SECONDARY ANALYSIS OF SUDAN MULTIPLE INDICATOR CLUSTER SURVEY 2014
Authors:   , Netsereab Tesfit
Published: November 2023

Diarrhea is the passage of three or more loose or liquid stools per day (or feces are discharged frequently from the bowl than the normal for the person). It is a leading cause of mortality and morbidity in children under the age of five in developing countries especially in the Sub-Sahara Africa including Sudan. The aim of the study was to explore the factors associated with diarrhea among children aged under 5 years in Sudan using the 2014 Sudan Multiple Indicator Cluster Survey (MICS). A total of 14081 children under 5 years old who had completed the survey questionnaire were considered for this study. Data was entered and cleaned using SPSS version 17. Bivariate analysis was done using Pearson’s Chi square test while multivariate analysis was done using binary logistic regression with 95% CI to examine the association between the dependent and independent variables. All variables with p-value <0.2 using the bivariate analysis was included in multivariate analysis. The prevalence of diarrhea was 26.9% (3785 children with diarrhea out of 14081). In multivariate analysis after controlling for other factors; children from the fourth wealth index quintile were 1.21 times more likely to develop diarrhea, (OR: 1.21, 95% CI: 1.037-1.423, P=0.016) than those children from the richest wealth index quintile. Children who were severely underweighted were 1.59 times more likely to develop diarrhea, (OR: 1.59, 95% CI: 1.301-1.948, P<0.001) than children who had a normal weight for age Z-score. The risk of diarrhea was 32% lower in severely wasted children, (OR: 0.68, 95% CI: 0.468-0.995, P=0.047) than those children who were obese. Children aged 6-11 and 12-23 months were about 2.5 times more at risk of getting diarrhea, (OR: 2.49, 95% CI: 2.105-2.944, P<0.001; OR: 2.45, 95% CI: 2.114-2.838, P<0.001 respectively) in comparison to children aged 48-59 months. Nutritional factors were found to be associated with diarrhea. Continuous governmental efforts to eradicate malnutrition and hunger are recommended. The MICS 2014 of Sudan has produced much of great value. But there are some questions about certain kinds of information. Unexpected results were found regarding main source and treatment of drinking water and toilet facilities. Further studies in the form of longitudinal studies are needed as one cannot infer causality using this kind of study.
STANDARDIZATION OF LONICERA JAPONICA FLOWERING BUD AND CONTENTS OF CHLOROGENIC, ROSMARINIC AND CAFFEIC ACIDS IN SELECTED THAI MEDICINAL PLANTS
Authors:   , Chaowuttikul Chayanon
Published: November 2023

Quantification of chlorogenic, rosmarinic and caffeic acids in 111 selected Thai medicinal plants using high performance liquid chromatography demonstrated that among 111 samples, 39.64% contained all of 3 compounds, 40.54% contained 2 compounds, 14.41% contained only 1 compound and 5.41% could not detect these 3 compounds. Lonicera japonica flowering buds were found to be the richest source for chlorogenic acid content, Melissa officinalis leaves showed the most rosmarinic acid content and the most caffeic acid content was found in Coffea canephora seeds. Pharmacognostic specification and chlorogenic acid content of L. japonica flowering bud from 15 various herbal drugstores throughout Thailand were established. Macroscopic and microscopic evaluation of flowering bud were demonstrated. Physico-chemical parameters including loss on drying, total ash, acid insoluble ash, water content, ethanol and water soluble extractive values were found to be 10.11, 6.59, 1.14, 10.82, 16.46 and 28.88 % by dry weight respectively. For quantitative analysis, chlorogenic acid content in flowering bud by TLC-densitometry compared to TLC-image analysis by imageJ software were found to be 2.24 and 2.09 g/100 g respectively which were not significantly different (P = 0.13). The validation parameters of all quantitative analysis were investigated according to ICH guideline. HPLC as well as TLC-densitometry and TLC-image analysis were demonstrated as suitable, reliable and efficient methods for the quantitative analyses. In vitro biological activities of L. japonica flowering bud compared to chlorogenic, rosmarinic and caffeic acids were evaluated by brine shrimp lethality assay, MTT cell viability assay, comet assay, antimicrobial activities, antioxidant activities and yeast alpha-glucosidase inhibition assay. The results demonstrated that flowering bud ethanolic extract showed non-toxicity on brine shrimp nauplii and 6 tested cell lines. Chlorogenic, rosmarinic and caffeic acids demonstrated toxicity against brine shrimp nauplii. They showed more cytotoxic potentials against tested cell lines than the extract but were still accepted as no cytotoxicity. The extract and 3 compounds showed human lymphocyte DNA damage by comet assay. They were no inhibitory activities against tested microorganisms. The extract and the compounds demonstrated the abilities of DPPH and nitric oxide scavenger and reducing power. However, only the compounds exhibited beta-carotene bleaching activity. Moreover, they inhibited enzyme activity in yeast alpha-glucosidase inhibition study.
Improving Vocabulary Mastery By Using Describing Pictures
Authors: Hayati Nur , Sholah Hanif Maulaniam
Published: November 2023

The results of this study are in the first cycle; the average result of the pre-test was 44. In the post-test, the average of the test results was 57. Next, in cycle two, the average result of the post-test was 76. There was an improvement in every cycle by describing the picture. The students who passed the passing grade in the pre-test of cycle II are 53.8%, but there is a different result in the post-test. 84.5% of students pass with an excellent score. From both test results, there is an improvement of about 30.7%. There is a significant improvement in cycle II. This increase can be seen from the value of each student, which has increased compared to the pre-test. There are improvements in 10, 12.5, 20, 22.5, and even 32.5. This improvement really proves that this method is able to improve vocabulary skills. Because more than 75% of students pass with good scores, this research fulfills the criteria for success.