bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-avoiding walks of specified lengths on rectangular grid graphs
Authors: Major László , Németh László , Pahikkala Anna , Szalay László
Published: July 2023

The investigation of self-avoiding walks on graphs has an extensive literature. We study the notion of wrong steps of self-avoiding walks on rectangular shape$$n\times m$$n×mgrids of square cells (Manhattan graphs) and examine some general and special cases. We determine the number of self-avoiding walks with one and with two wrong steps in general. We also establish some properties, like unimodality and sum of the rows of the Pascal-like triangles corresponding to the walks. We also present particular recurrence relations on the number of self-avoiding walks on the$$n\times 2$$n×2grids with any specified number of wrong steps.
The microcopepod family Oncaeidae: state of knowledge and perspectives
Authors: Böttger-Schnack Ruth , Schnack Dietrich
Published: July 2023

Since the discovery of the first oncaeid copepod described by Philippi in 1843 as Oncaea venusta, great progress has been achieved regarding the morphological/descriptive taxonomy of the microcopepod family Oncaeidae, occurring in all great oceans and all depth layers of the ocean. The species diversity of this family is still underestimated and the ecological role of oncaeids within the marine ecosystem is not yet well understood, but the life strategy appears to be fundamentally different from most other pelagic microcopepod families. The present paper aims at a comprehensive review of the current state of knowledge of this microcopepod family, including taxonomic and phylogenetic issues, questions of species identification, specific morphological and molecular genetic characteristics, information on regional and vertical distribution and abundance, motion behaviour, feeding and food relationships, reproduction aspects, biomass and elemental composition, respiration and metabolic rates. Relevant open questions are highlighted, and examples are given of shortcomings and high uncertainties in results of current attempts to include oncaeid copepods in various aspects of global marine ecosystem studies. It is concluded that continued support of taxonomic research is required for Oncaeidae and other small copepod species, based on an integrated approach of morphological and molecular genetic methods and user-friendly regional identification keys, to allow an adequate consideration of oncaeids in advanced ecological studies and to achieve a better understanding of the ecological role of this abundant microcopepod family in marine ecosystems.
The Added Diagnostic Value of Transcatheter CT Hepatic Arteriography for Intraprocedural Detection of Previously Unknown Colorectal Liver Metastases During Percutaneous Ablation and Impact on the Definitive Treatment Plan
Authors: van der Lei Susan , Opperman Jip , Dijkstra Madelon , Kors Nikita , Boon Rianne , van den Bemd Bente A. T. , Timmer Florentine E. F. , Nota Irene M. G. C. , van den Bergh Janneke E. , de Vries Jan J. J. , Scheffer Hester J. , Geboers Bart , Neuss Timothy , Schouten Evelien , Lissenberg-Witte Birgit I. , Puijk Robbert S. , Meijerink Martijn R.
Published: July 2023

Purpose

This study assessed the diagnostic value of CT hepatic arteriography (CTHA) for the intraprocedural detection of previously unknown colorectal liver metastases (CRLM) and the impact on the definitive treatment plan.

Materials and Methods

All patients treated with CTHA-guided percutaneous ablation for CRLM between January 2012 and March 2022 were identified from the Amsterdam Colorectal Liver Met Registry (AmCORE). Radiology reports of the ablative procedure and follow-up imaging were reviewed to see if (a) previously unknown CRLM were detected intra-procedurally and if (b) new CRLM, potentially missed on CTHA, appeared within 6 months following the procedure; three abdominal radiologists re-reviewed the baseline CTHA scans of these patients with early recurrence. To ratify immediate ablations of concomitantly detected CRLM, the upper limit of false positives was predefined at 10%.

Results

One hundred and fifty-two patients were included. With CTHA, a total of 17 additional tumours in 15 patients were diagnosed and treated immediately, two representing disappeared tumours following systemic chemotherapy. Compared to the conventional contrast-enhanced (ce)CT, ceMRI and 18F-FDG PET-CT, adding CTHA was superior for the detection of CRLM (P < .001). Within 12 months of follow-up 121, new CRLM appeared in 49/152 patients (32.2%); retrospective blinded assessment revealed 56 to already be visible on the baseline CTHA scan (46%); four lesions without substrate on follow-up scans were considered false positives (n = 4/60; 7%). Arterial ring enhancement was the most frequently reported imaging characteristic (n = 45/60; 75%).

Conclusion

The subsequent use of CTHA has added value for the detection of previously unknown and vanished CRLM. Taking into account the low number of false positives (7%) and the favourable safety profile of percutaneous ablation, we believe that immediate ablation of typical ring-enhancing supplementary tumours is justified and sufficiently validated.

Level of Evidence

Level 3; individual cross-sectional study with consistently applied reference standard and blinding.
The graft-versus-leukemia effect of prophylactic donor lymphocyte infusions after allogeneic stem cell transplantation is equally effective in relapse prevention but safer compared to spontaneous graft-versus-host disease
Authors: Stadler Michael , Hambach Lothar , Dammann Elke , Diedrich Helmut , Kamal Haytham , Hamwi Iyas , Schultze-Florey Christian , Varvenne Michael , Ehrlich Steve , Buchholz Stefanie , Koenecke Christian , Beutel Gernot , Weissinger Eva M. , Krauter Jürgen , Eder Matthias , Hertenstein Bernd , Ganser Arnold
Published: July 2023

Therapeutic donor lymphocyte infusions (tDLI) are used to reinforce the graft-versus-leukemia (GvL) effect in relapse after allogeneic stem cell transplantation (alloSCT). In contrast, the role of prophylactic DLI (proDLI) in preventing leukemia relapse has been less clearly established, although supported by retrospective, case-control, and registry analyses. We report a prospective, monocentric, ten year cohort of patients with high risk acute leukemias (AL) or myelodysplasia (MDS) in whom proDLI were applied beyond day +120 post alloSCT to compensate for lack of GvL.

272 consecutive allotransplanted AL or MDS patients in complete remission and off immunosuppression at day +120 were stratified according to the prior appearance of relevant GvHD (acute GvHD °II-IV or extensive chronic GvHD) as a clinical indicator for GvL. Escalating doses of unmodified proDLI were applied to 72/272 patients without prior relevant GvHD. Conversely, 157/272 patients with prior spontaneous GvHD did not receive proDLI, nor did 43/272 patients with contraindications (uncontrolled infections, patient refusal, DLI unavailability).

By day 160-landmark analysis (median day of first DLI application), proDLI recipients had significantly higher five-year overall (OS) and disease free survival (DFS) (77% and 67%) than patients with spontaneous GvHD (54% and 53%) or with contraindications (46% and 45%) (p=0.003). Relapse incidence for patients with proDLI (30%) or spontaneous GvHD (29%) was significantly lower than in patients with contraindications (39%; p=0.021). With similar GvHD incidence beyond day +160, non-relapse mortality (NRM) was less with proDLI (5%) than without proDLI (18%; p=0.036).

In conclusion, proDLI may be able to compensate for lack of GvL in alloSCT recipients with high risk AL or MDS.
Programmed death-ligand 1 (PD-L1) expression in primary gastric adenocarcinoma and matched metastases
Authors: Liu Drolaiz H. W. , Grabsch Heike I. , Gloor Beat , Langer Rupert , Dislich Bastian
Published: July 2023

Background

Combination of immunotherapy and chemotherapy is recommended for first line treatment of gastric adenocarcinoma (GC) patients with locally advanced unresectable disease or metastatic disease. However, data regarding the concordance rate between PD-L1 combined positive score (CPS) in primary GC and matched regional lymph node metastasis (LNmet) or matched distant metastasis (Dmet) is limited.

Methods

Tissue microarray sections from primary resected GC, LNmet and Dmet were immunohistochemically stained with anti-PD-L1 (clone SP263). PD-L1 expression was scored separately in tumour cells and immune cells and compared between matched primary GC, LNmet and/or Dmet. CPS was calculated and results for CPS cut-offs 1 and 5 were compared between matched samples.

Results

275 PD-L1 stained GC were analysed. 189 primary GC had matched LNmet. CPS cut-off 1 concordance rate between primary GC and LNmet was 77%. 23 primary GC had matched Dmet but no matched LNmet, CPS cut-off 1 concordance rate was 70%. 63 primary GC had both matched LNmet and matched Dmet, CPS cut-off 1 concordance rate of 67%. CPS cut-off 5 results were similar. The proportion of PD-L1 positive tumour cells increased from primary GC (26%) to LNmet (42%) and was highest in Dmet (75%).

Conclusion

Our study showed up to 33% discordance of PD-L1 CPS between primary GC and LNmet and/or Dmet suggesting that multiple biopsies of primary GC and metastatic sites might need to be tested before considering treatment options. Moreover, this is the first study that seems to suggest that tumour cells acquire PD-L1 expression during disease progression.
Early clinical trial unit tumor board: a real-world experience in a national cancer network
Authors: Weiss L. , Dorman K. , Boukovala M. , Schwinghammer F. , Jordan P. , Fey T. , Hasselmann K. , Subklewe M. , Bücklein V. , Bargou R. , Goebeler M. , Sayehli C. , Spoerl S. , Lüke F. , Heudobler D. , Claus R. , von Luettichau I. , Lorenzen S. , Lange S. , Westphalen C. B. , von Bergwelt-Baildon M. , Heinemann V. , Gießen-Jung C.
Published: July 2023

Purpose

Early clinical trials are the first step into clinical therapies for new drugs. Within the six Bavarian university-based hospitals (Augsburg, Erlangen, Regensburg, Munich (LMU and TU), Würzburg) we have enrolled a virtual network platform for patient discussion.

Methods

The virtual Early Clinical Trial Unit Tumor Board (ECTU Tumor Board) is a secured web-based meeting to evaluate early clinical trial options for patients, where representatives from local ECTUs participate. We retrospectively analyzed patient cases discussed between November 2021 and November 2022.

Results

From November 2021 to November 2022, a total of 43 patients were discussed in the ECTU Tumor Board. Median age at diagnosis was 44.6 years (range 10–76 years). The median number of previous lines of therapies was 3.7 (range 1–9 therapies) including systemic treatment, surgery, and radiation therapy. A total of 27 different tumor entities were presented and 83.7% (36/43) patients received at least one trial recommendation. In total, 21 different active or shortly recruiting clinical trials were recommended: ten antibody trials, four BiTE (bispecific T cell engager) trials, six CAR (chimeric antigen receptor) T-cell trials, and one chemotherapy trial. Only six trials (28.6%) were recommended on the basis of the previously performed comprehensive genetic profiling (CGP).

Conclusion

The ECTU Tumor Board is a feasible and successful network, highlighting the force of virtual patient discussions for improving patient care as well as trial recruitment in advanced diseases. It can provide further treatment options after local MTB presentation, aiming to close the gap to access clinical trials.
Numerical simulation of the extrusion and layer deposition processes in 3D concrete printing with the Particle Finite Element Method
Authors: Rizzieri Giacomo , Ferrara Liberato , Cremonesi Massimiliano
Published: July 2023

3D Concrete Printing (3DCP) is a rapidly evolving technology that allows for the efficient and accurate construction of complex concrete objects. In this paper, a numerical modelling approach is presented for the simulation of the printing process of cementitious materials, based on the homogeneous fluid assumption. To cope with the large deformations of the domain and the nonlinearity resulting from the use of a non-Newtonian rheological law, the Navier–Stokes equations are solved in the framework of the Particle Finite Element Method (PFEM). Furthermore, tailored solutions have been formulated and implemented for the time-dependent moving boundary conditions at the nozzle outlet and for the efficient handling of the inter-layer contact in the same PFEM framework. The overall computational cost is decreased by the implementation of an adaptive de-refinement technique, which drastically reduces the number of degrees of freedom in time. The proposed modelling approach is finally validated by simulating the printing process of six rectilinear layers and one multi-layer “wall”. The results show good agreement with the experimental data and provide valuable insights into the printing process, paving the way for the use of numerical modelling tools for the optimization of materials and processes in the field of 3D Concrete Printing.
Correlation of mucosal healing endpoints with long-term clinical and patient-reported outcomes in ulcerative colitis
Authors: Parkes Gareth , Ungaro Ryan C. , Danese Silvio , Abreu Maria T. , Arenson Ethan , Zhou Wen , Ilo Dapo , Laroux F. Stephen , Deng Huiwen , Sanchez Gonzalez Yuri , Peyrin-Biroulet Laurent
Published: July 2023

Background

We evaluated the clinical relevance of achieving histologic endoscopic mucosal improvement (HEMI) and the more stringent target of histologic endoscopic mucosal remission (HEMR) in the phase 3 maintenance trial of upadacitinib for moderately to severely active ulcerative colitis.

Methods

Clinical and patient-reported outcomes were assessed in patients with clinical response after 8- or 16-week upadacitinib induction who received 52-week upadacitinib maintenance treatment. Cross-sectional and predictive analyses evaluated the relationship between HEMR or HEMI at Week 8/16 and Week 52, respectively, and outcomes at Week 52. Adjusted odds ratios (aOR) were derived from logistic regressions for patients achieving HEMR or HEMI without HEMR versus those not achieving HEMI.

Results

Cross-sectional analyses showed that patients with HEMR had greater odds of achieving all clinical and patient-reported outcomes at Week 52 than those not achieving HEMI. In predictive analyses, patients with HEMR at Week 8/16 had significantly greater odds of achieving clinical remission (aOR = 3.6, p = 0.001) and endoscopic remission (aOR = 3.9, p < 0.001) at Week 52 than patients not achieving HEMI and HEMR. For patients achieving HEMI without HEMR, these odds were lower: clinical remission (aOR = 3.2, p < 0.001) and endoscopic remission (aOR = 2.4, p = 0.010). The odds of achieving clinically meaningful improvements in most patient-reported outcomes were directionally similar between HEMI and HEMR, but not statistically different to patients not achieving HEMI. No hospitalizations or surgeries were observed in patients with HEMR at Week 52.

Conclusions

Achievement of HEMR or HEMI is clinically relevant with HEMR being associated with greater likelihood of improvement in long-term clinical and patient-reported outcomes. https://www.clinicaltrials.gov NCT02819635.
Behavioural responses to horizontal vibrations of quasi-2D ideal granular beds: an experimental approach
Authors: Moss J. , Glovnea R.
Published: July 2023

In this experimental study, granular bed response to horizontal vibrations of various frequencies and amplitudes are examined with high-speed imaging. Ideal granular beds consisting of spherical glass beads are horizontally vibrated in a quasi-two-dimensional arrangement, firstly with homogeneous granular media and then with a ternary mixture to explore how bed response deviates with changes to material composition. Phenomena of note are the tendency for the homogeneous material to subdivide into discrete areas of crystalline lattice structures, bounded by non-crystalline lines of bead contacts, labelled in this paper as ‘shear lines’. Shear line failure arises as neighbouring crystalline areas slide relative to one another along their shared non-crystalline border, combining to form one larger crystalline area. Under vibration conditions where particle agitation and relative movement is high, sloshing occurs in the upper bed and triangular granular-gas regions form in the top corners. The ternary mixture also exhibits sloshing at low frequency and large amplitude, but the inhomogeneity of its composition prevents formation of ordered crystalline regions and shear lines, instead promoting low percolation and a jamming effect underneath the sloshing region. Surprisingly strong convective responses are induced in the inhomogeneous bed with more energetic vibrations. From the analysis of shear lines in the homogeneous beds, and of convection in the inhomogeneous beds, comparisons between homogeneous and inhomogeneous bed behaviour are drawn. Results are used to discuss how behavioural response of non-cohesive granular material to horizontal vibrations is ultimately tied to, and changes with, the geometric complexity of the internal packing structure. The concept of ‘geometric compatibility’ between constituent particle species in an inhomogeneous granular medium is proposed as an explanation for the low percolation and strong convective response to vibration.

Graphical abstract
Sexual health in long-term breast cancer survivors: a comparison with female population controls from the HUNT study
Authors: Smedsland Solveig K. , Vandraas Kathrine F. , Falk Ragnhild S. , Horn Julie , Reidunsdatter Randi J. , Kiserud Cecilie E. , Dahl Alv A. , Brekke Mette , Reinertsen Kristin V.
Published: July 2023

Purpose

Sexual health is an important aspect of quality of life. Knowledge concerning sexual health in long-term breast cancer survivors (BCSs) is limited. This study compared sexual health in BCSs 8 years after diagnosis with similarly aged controls and examined the impact of menopausal status at diagnosis and systemic breast cancer treatments on sexual health.

Methods

Women aged 20–65 years when diagnosed with stage I–III breast cancer in 2011–2012 were identified by the Cancer Registry of Norway (n = 2803) and invited to participate in a nationwide survey. Controls were women from the Trøndelag Health Study (HUNT4). Sexual functioning and sexual enjoyment were measured by the EORTC QLQ-BR23 subscales scored from 0 to 100, and sexual discomfort by the Sexual Activity Questionnaire scored from 0 to 6. Linear regression analyses with adjustments for sociodemographic and health-related variables were performed to compare groups. Differences of ≥ 10% of range score were considered clinically significant.

Results

The study samples consisted of 1241 BCSs and 17,751 controls. Sexual enjoyment was poorer (B − 13.1, 95%CI − 15.0, − 11.2) and discomfort higher (B 0.9, 95%CI 0.8, 1.0) among BCSs compared to controls, and larger differences were evident between premenopausal BCSs and controls (B − 17.3, 95%CI − 19.6, − 14.9 and B 1.2, 95%CI 1.0, 1.3, respectively). BCSs treated with both endocrine- and chemotherapy had lower sexual functioning (B − 11.9, 95%CI − 13.8, − 10.1), poorer sexual enjoyment (B − 18.1, 95%CI − 20.7, − 15.5), and more sexual discomfort (B 1.4, 95% 1.3, 1.6) than controls.

Conclusion

Sexual health impairments are more common in BCSs 8 years after diagnosis compared to similar aged population controls. During follow-up, attention to such impairments, especially among women diagnosed at premenopausal age and treated with heavy systemic treatment, is warranted.
A space–time variational method for optimal control problems: well-posedness, stability and numerical solution
Authors: Beranek Nina , Reinhold Martin Alexander , Urban Karsten
Published: July 2023

We consider an optimal control problem constrained by a parabolic partial differential equation with Robin boundary conditions. We use a space–time variational formulation in Lebesgue–Bochner spaces yielding a boundedly invertible solution operator. The abstract formulation of the optimal control problem yields the Lagrange function and Karush–Kuhn–Tucker conditions in a natural manner. This results in space–time variational formulations of the adjoint and gradient equation in Lebesgue–Bochner spaces, which are proven to be boundedly invertible. Necessary and sufficient optimality conditions are formulated and the optimality system is shown to be boundedly invertible. Next, we introduce a conforming uniformly stable simultaneous space–time (tensorproduct) discretization of the optimality system in these Lebesgue–Bochner spaces. Using finite elements of appropriate orders in space and time for trial and test spaces, this setting is known to be equivalent to a Crank–Nicolson time-stepping scheme for parabolic problems. Comparisons with existing methods are detailed. We show numerical comparisons with time-stepping methods. The space–time method shows good stability properties and requires fewer degrees of freedom in time to reach the same accuracy.
Trophic state and potential productivity assessment for Qaroun Lake using spatial techniques
Authors: Mohamed Hagar M. , Khalil Magdy T. , El-Zeiny Ahmed M. , Khalifa Nehad , Kafrawy Sameh B. El , Emam Wiam W. M.
Published: July 2023

Qaroun Lake is one of the most important Egyptian lakes which, recently, have been exposed to severe degradation in water quality and fish productivity. In this manuscript, Carlson’s trophic state index (CTSI) was used to evaluate the trophic state, while the trophometric index (TMI) was used to assess the potential productivity of Qaroun Lake. The present study is one of the initial attempts to investigate these indices in Qaroun Lake. To achieve this work, an integrated multidisciplinary approach was adopted integrating field investigation, geographic information system, and data analysis. CTSI combines three variables of water quality: chlorophyll-a (CHL-a), total phosphorus (TP), and transparency measured by Secchi disk depth (SDD). The result of overall CTSI showed the hypereutrophic state is represented by 62% and eutrophic state is represented by 38% of the total lake’s area. Moreover, the calculated TMI indicated the average potential productivity value (PP) is 619 t. It can be concluded that the hypereutrophic is the dominant state in Qaroun Lake. The present study recommends the application of TMI model to evaluate and monitor the changes in Qaroun Lake’s potential productivity in response to the changing environmental conditions and other biological pressures (e.g., Isopoda paraside).
Posterior wall thickness of the confluent inferior pulmonary veins measured by left atrial intracardiac echocardiography: implications for catheter ablation
Authors: Negishi Kodai , Okumura Ken , Onishi Fumitaka , Yoshimura Akino , Okamatsu Hideharu , Tsurugi Takuo , Tanaka Yasuaki , Sakai Yoshiro , Nakao Koichi , Sakamoto Tomohiro , Koyama Junjiro , Tomita Hirofumi
Published: July 2023

Background

Confluent inferior pulmonary veins (CIPV) is a rare anatomical variant. There is few evidence in the literature regarding anatomic landmarks consideration to guide radiofrequency application in avoiding complications in the esophagus in CIPV cases.

Methods

Of 986 consecutive patients undergoing atrial fibrillation (AF) ablation from July 2020 to June 2022, seven (0.7%) had CIPV with a common trunk connecting to the LA diagnosed by 3-dimensional contrast-enhanced computed tomography. Using intracardiac echocardiography (ICE) performed from the left atrium (LA), we measured the posterior wall thickness (PWT) of the CIPV adjacent to the esophagus and compared the measurement with the LA posterior wall thickness (LAPWT) at the left inferior PV level of 25 controls without CIPV. For ablation in CIPV patients, each superior PV was individually isolated, and box isolation of CIPV without ablating the CIPV posterior wall was added (tri-circle ablation technique).

Results

The CIPV PWT was 0.7 ± 0.1 mm, while non-CIPV LAPWT was 2.0 ± 0.4 mm (P < 0.001). In the CIPV group, upper and lower portions of the CIPV were both apart from the esophagus (mean distances, 6.7 ± 3.4 mm and 7.9 ± 2.7 mm, respectively). Individual superior PV isolation and box CIPV isolation resulted in complete isolation of all PVs, with no complications. All CIPV patients except one remained AF recurrence-free for 376 ± 52 days.

Conclusions

Although CIPV frequency is low, CIPV PWT is very thin and special care is needed during ablation. A “tri-circle” ablation strategy avoids ablating in the thinnest portion of the posterior wall. Further studies are warranted to assess the safety.
Investigating the Measurement Invariance of the Caregiver-Teacher Report Form (C-TRF) Factors in a Norwegian Early Childhood Education and Care Context
Authors: Stensen Kenneth , Lydersen Stian , Ranøyen Ingunn , Lekhal Ratib , Drugli May Britt , Buøen Elisabet Solheim
Published: July 2023

The Caregiver-Teacher Report Form (C-TRF) is an instrument frequently used by researchers and clinicians to assess psychopathology in preschool children based on information from early childhood education and care professionals. However, the measurement invariance of this instrument has not been investigated. Thus, the aim of the current study was to investigate the measurement invariance of the C-TRF for (1) girls vs. boys, and (2) for children below the age of three years old vs. three years or older, as measurement invariance is a prerequisite for a meaningful comparison of latent means between groups. Based on reports of 2904 children from 353 early childhood education and care professionals, our results showed full scalar invariance for an adapted C-TRF model, which supports the applicability of the instrument. However, awareness of the factor Somatic complaints and items with out-of-range parameters is warranted.
Effect of PI3K/AKT/mTOR signaling pathway-based clustered nursing care combined with papaverine injection on vascular inflammation and vascular crisis after replantation of severed fingers
Authors: Wang Na , Xiao Haijing , Lu Hongyan , Chen Kai , Zhang Shuhong , Liu Fei , Zhang Ning , Zhang Haijing , Chen Siyu , Xu Xiaoli
Published: July 2023

This research aimed to investigate the effect of PI3K (phosphatidylinositol 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target protein of rapamycin) signaling pathway-based clustering care combined with papaverine injection on vascular inflammation and vascular crisis after finger amputation and replantation. 100 patients admitted in General Hospital of Ningxia Medical University from April 2022 to December 2022 for replantation of severed fingers were selected and divided into a control group (n = 50) and an observation group (n = 50) using the randomized grouping principle. The control group received a papaverine injection and general nursing care, the observation group received a papaverine injection and clustered care. The pain score; constipation incidence; replantation finger survival rate; physician, nurse, and patient satisfaction; serum inflammatory factors; vascular crisis parameters; and occurrence of adverse reactions were compared between the two patient groups. Enzyme-linked immunosorbent assay was performed to detect PI3K, AKT, and mTOR protein concentrations in the venous blood of the two groups, and statistical analysis of the data was performed. On postoperative day 7, the pain score and incidence of constipation in the observation group were lower than those in the control group (P < 0.05); the survival rate of reimplanted fingers in the observation group was 88.00%, which was higher than that in the control group 80.00% (P < 0.05); the satisfaction of doctors, nurses, and patients in the observation group was higher than that in the control group; the concentrations of interleukin-1 (IL-1), tumor necrosis factor (TNF-α), blood flow resistance index (RI), and arterial pulsatility index (PI) in the observation group were lower than those in the control group, while the concentration of interleukin-10 (IL-10), vascular diameter, and Vm (mean blood flow velocity) were higher in the observation group than those in the control group; the differences were statistically significant (P < 0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P > 0.05). The concentrations of PI3K, AKT, and mTOR proteins in the observation group were higher than those in the control group (P < 0.05). The concentrations of PI3K, AKT, and mTOR proteins in the observation group were higher than those in the control group (P < 0.05). Overall, these findings suggest that clustered care combined with papaverine injection reduces vascular inflammatory symptoms and vascular crisis in the treatment of severed finger replantation through the PI3K/AKT/mTOR signaling pathway.
Lasst uns unsere Tools gemeinsam bauen!
Authors: Hepp Andreas , Hohmann Florian , Belli Alessandro
Published: July 2023

Der Artikel stellt das nutzer:innenzentrierte Verfahren der „Co-Creation“ für die selbst-reflexive Entwicklung von Forschungssoftware in der Kommunikations- und Medienwissenschaft vor. Im Kern sollen dabei drei Vorzüge von Co-Creation deutlich gemacht werden: Erstens ermöglicht es Co-Creation, Forschungssoftware mit engem Bezug auf bestehende Forschungspraktiken zu entwickeln. Zweitens hilft Co-Creation, Forschungssoftware dicht an die Handlungspraktiken von Menschen im Alltag heranzuführen und diese dabei als beforschte Subjekte ernst zu nehmen. Und drittens fördert Co-Creation die Entwicklung einer Forschendengemeinschaft um die jeweilige Forschungssoftware, die so deren nachhaltige Absicherung stützt. Um dies zu verdeutlichen, wird das Verfahren des Co-Creation als eine bestimmte Umgangsweise mit Infrastrukturen diskutiert, die das unsichtbare Arbeiten an ihr sichtbar und damit auch reflektierbar macht. Anschließend stellen wir den iterativen Prozess des Co-Creation detaillierter vor. Dabei legen wir die Ebenen der Praxis der Beforschten, der Praxis der Forschenden und der Praxis der Implementierenden mit ihren je spezifischen Methoden dar, die einem qualitativen Forschungsdesign der Kommunikations- und Medienwissenschaft nahestehen. Im Fazit wird das Potenzial von Co-Creation weit über die Entwicklung von Forschungssoftware hinaus diskutiert.
Sarcopenia, a condition shared by various diseases: can we alleviate or delay the progression?
Authors: Tarantino Giovanni , Sinatti Gaia , Citro Vincenzo , Santini Silvano , Balsano Clara
Published: July 2023

Sarcopenia is a severe condition common to various chronic diseases and it is reckoned as a major health problem. It encompasses many different molecular mechanisms that have been for a while discovered but not definitely clarified. Although sarcopenia is a disability status that leads to serious health consequences, the scarcity of suitable animal models has curtailed research addressing this disorder. Another limitation in the field of clinical investigation of sarcopenic patients is the lack of a generally accepted definition coupled with the difficulty of adopting common diagnostic criteria. In fact, both do not permit to clarify the exact prevalence rate and consequently limit physicians to establish any kind of therapeutical approach or, when possible, to adopt preventive measures. Unfortunately, there is no standardized cure, apart from doing more physical activity and embracing a balanced diet, but newly discovered substances start being considered. In this review, authors try to give an overview addressing principal pathways of sarcopenia and offer critical features of various possible interventions.
Immunohistochemical expression of HMGB1 and related proteins in the skin as a possible tool for determining post-mortem interval: a preclinical study
Authors: De-Giorgio Fabio , Bergamin Eva , Baldi Alfonso , Gatta Roberto , Pascali Vincenzo L.
Published: July 2023

Determining the post-mortem interval (PMI) is one of forensic pathology’s primary objectives and one of its most challenging tasks. Numerous studies have demonstrated the accuracy of histomorphology and immunohistochemical investigations in determining the time of death. Nevertheless, the skin, a robust and easy-to-remove tissue, has only been partially analyzed so far. By studying 20 adult male mice, we tried to determine whether post-mortem immunohistochemical detection in the skin of HMGB1 proteins and associated components (Beclin1 and RAGE) could be used for this purpose. We discovered that nuclear HMGB1 overexpression indicates that death occurred within the previous 12 h, nuclear HMGB1 negativization with high cytoplasmic HMGB1 intensity indicates that death occurred between 12 and 36 h earlier and cytoplasmic HMGB1 negativization indicates that more than 48 h have passed since death. RAGE and Beclin1 levels in the cytoplasm also decreased with time. The latter proteins’ negativization might indicate that more than 24 and 36 h, respectively, have passed from the time of death. These indicators might potentially be helpful in forensic practice for determining the PMI using immunohistochemistry.
C. Wright Mills in Copenhagen: Collaboration, Politics, and the Making of 'The Sociological Imagination
Authors: Petersen Klaus
Published: July 2023

American sociologist C. Wright Mills is one of the most important and controversial sociologists of the post-war period. Of Mills’ works, one book stands out:The Sociological Imagination, published by Oxford University Press in 1959. Little known is that Mills drafted his book during a 12-month Fulbright visit to University of Copenhagen 1956-1957. In the rich biographical literature on Mills this is mentioned only in the passing, or not at all. Based on hitherto unused archival material, this paper offers the first detailed account of his Copenhagen-visit during the Cold War. Bringing together this bulk of new historical traces sheds new light on the year Mills himself referred to as a “pivotal moment.” These 12 months in Copenhagen, amid the Cold War, was formative for Mills in two ways: First, Copenhagen was an entrepot to European center-left thinking both east and west of the Iron Curtain. Second, the stay in Copenhagen offered a ‘space of selfhood’, allowing Mills a necessary respite to develop his critical thinking. He did so in close cooperation with like-minded colleagues in Copenhagen. In the mid-1950s, the discipline was in the making in Denmark, and the visit of a prominent US scholar like Mills offered opportunities for Danish sociologist to further the discipline – and their standing within the discipline.
Impact of contemporary filial piety on the voluntary service behaviour of adolescents: a moderated mediation framework
Authors: Yuan Shujie , Jiang Runbin , Liu Jiayun
Published: July 2023

A timely understanding of adolescents’ voluntary service behaviour and its influencing mechanism is of great importance for promoting the sustainable development of voluntary service. This study explores the relationship between contemporary filial piety and voluntary service behaviour. A two-wave study was conducted among 339 adolescents in China to explore the mediating role of empathy and the moderating role of psychological collectivism between contemporary filial piety and voluntary service behaviour through structural equation modelling. We found that contemporary filial piety not only had a direct effect on voluntary service behaviour but also affected voluntary service behaviour through the mediating role of empathy. Psychological collectivism moderates the first half of the mediation path “contemporary filial piety→empathy→voluntary service behaviour.” The results reveal the mechanism by which contemporary filial piety influences adolescents’ voluntary service behaviour and provides an important reference for voluntary work.
Pathways from livestock to improved human nutrition: lessons learned in East Africa
Authors: Flax Valerie L. , Ouma Emily A. , Baltenweck Isabelle , Omosa Esther , Girard Amy Webb , Jensen Nathaniel , Dominguez-Salas Paula
Published: July 2023

The Livestock CGIAR (Consultative Group on International Agricultural Research) Research Program (Livestock CRP) generated evidence on livestock-to-nutrition pathways through the implementation of nutrition-related livestock programs and research. In this analysis, we compiled lessons learned from Livestock CRP projects and identified recommendations for nutrition-sensitive livestock programming and research in the context of the literature and through the development of an updated livestock-to-nutrition pathways framework. The updated framework shows the interconnected nature of the three main pathways—own-consumption, income, and women’s empowerment—along with other pathways and includes contextual factors, which were lacking in previous frameworks. Eight Livestock CRP projects were reviewed, including five integrated livestock and human nutrition projects, two studies on drivers of food choice, and one study to develop and test a tool to measure nutrition outcomes among pastoralists. Key lessons learned were that women’s empowerment in livestock-to-nutrition pathways is important, but challenging to measure; engaging male partners improves nutrition in livestock-keeping households; nutrition-sensitive livestock programs and researchers should articulate and measure livestock-to-nutrition pathways they are addressing; livestock keeping does not guarantee access to animal source foods; context and livelihoods are not static and program design should be adapted accordingly; and digital data collection systems can provide accurate and timely nutrition information. Key recommendations include developing tools to fill measurement gaps; creating shorter versions of validated tools for ease of use; using complexity-aware evaluation methods to capture the interconnected nature of livestock-to-nutrition pathways and shifting livelihoods; and conducting pathways analyses to better understand linkages in the framework and further refine it.
Field Efficacy, Sub-lethal, and Biochemical Effects of Certain Biorational Insecticides Against the New Intruder, Spodoptera frugiperda in Bani-Suef, Upper Egypt
Authors: Khamis Wael M. , El-Sabrout Ahmed M. , Shahin Rima , Abdel-Rahim Elham F.
Published: July 2023

Frequent inspections on sorghum and maize crops during seasons of 2021 and 2022 in some regions in Bani-Suef governorate, Egypt, discovered unprecedented invasions of Spodoptera frugiperda (J. E. Smith). Accordingly, our study on Beauveria bassiana and spinetoram was supporter to the Food and Agriculture Organization’s tendency in adopting biorational insecticides against S. frugiperda in Egypt. Exposure toxicity of LC25 values at 48 h of B. bassiana were 2.7 × 106 and 5.2 × 106 conidia mL−1 and spinetoram were 0.019 and 0.048 mg L−1 against the 2nd and 4th instar larvae laboratory strain of S. frugiperda, respectively. Sub-lethal effects (LC25) were accomplished on biological parameters against both instar larvae. LC25 of B. bassiana reduced adult emergency (89.91 and 91.05%) more than spinetoram (75.99 and 79.49%) against the 2nd and 4th instar larvae, respectively. The 2nd instar larvae exposed to LC25 of B. bassiana suppressed female fecundity (0.00 eggs) more than spinetoram (19.74 eggs). Enzymatic activity of lipase in hemolymph, fat bodies, and mid-gut of the 4th instars at 48 h showed significant drop in B. bassiana more than spinetoram. Glutathione-S-transferase (GST) levels in hemolymph for both insecticides were equal and exceeded the control. Fat bodies and mid-gut possessed the highest GST activity in B. bassiana followed by spinetoram and the control. Residual efficacy of spinetoram exceled B. bassiana at their field rates under semi-field condition in Bani-Suef along the two seasons of maize crop against both instars. Eventually, B. bassiana alongside spinetoram could afford good control especially on early instar larvae of S. frugiperda.
An improved estimation of distribution algorithm for rescue task emergency scheduling considering stochastic deterioration of the injured
Authors: Xu Ying , Li Xiaobo , Li Qian , Zhang Weipeng
Published: July 2023

Efficient allocating and scheduling emergency rescue tasks are a primary issue for emergency management. This paper considers emergency scheduling of rescue tasks under stochastic deterioration of the injured. First, a mathematical model is established to minimize the average mathematical expectation of all tasks’ completion time and casualty loss. Second, an improved multi-objective estimation of distribution algorithm (IMEDA) is proposed to solve this problem. In the IMDEA, an effective initialization strategy is designed for obtaining a superior population. Then, three statistical models are constructed, which include two tasks existing in the same rescue team, the probability of first task being processed by a rescue team, and the adjacency between two tasks. Afterward, an improved sampling method based on referenced sequence is employed to efficiently generate offspring population. Three multi-objective local search methods are presented to improve the exploitation in promising areas around elite individuals. Furthermore, the parameter calibration and effectiveness of components of IMEDA are tested through experiments. Finally, the comprehensive comparison with state-of-the-art multi-objective algorithms demonstrates that IMEDA is a high-performing approach for the considered problem.
Neurodiversity in Practice: a Conceptual Model of Autistic Strengths and Potential Mechanisms of Change to Support Positive Mental Health and Wellbeing in Autistic Children and Adolescents
Authors: Cherewick Megan , Matergia Michael
Published: July 2023

Objectives

Neurodiversity affirming frameworks are a paradigm shift from a deficit-focused approach to autism to recognizing autism as a heterogeneous constellation of differences in abilities and strengths. This article completed a literature review and data synthesis to (1) identify autistic strengths used in the design of psychosocial interventions, (2) propose mechanisms of change that explain strength-based psychosocial intervention effects on mental health and wellbeing outcomes, and (3) integrate findings in a conceptual model for testing in future research studies.

Methods

A search for articles was completed in June 2023 and resulted in 24 articles that met the inclusion criteria. The Distillation and Matching Model methods were used to code articles and subsequent conceptual groupings generated categorical domains included in the conceptual model.

Results

Autistic strengths identified in the design of psychosocial interventions were grouped into four domains: (1) perceptual, (2) reasoning, (3) expertise, and (4) character strengths. Mechanisms of change were grouped into four domains: (1) affective, (2) behavioral, (3) cognitive, and (4) physiological. The resulting conceptual model presents autistic strengths that can be leveraged in psychosocial interventions and potential mechanisms of change that explain intervention effects on mental health and wellbeing.

Conclusions

Growing focus on the translation of positive psychology has resulted in strength-based psychosocial intervention programs. However, intervention strategies have not leveraged the diverse array of autistic strengths identified by autistic individuals, their families, and their communities. Furthermore, research is needed to determine mechanistic paths by which strength-based interventions achieve positive effects on mental health outcomes in autistic children and adolescents.
Telomere Length in Patients with Gestational Diabetes Mellitus and Normoglycemic Pregnant Women: a Systematic Review and Meta-analysis
Authors: Pérez-López Faustino R. , López-Baena María T. , Ulloque-Badaracco Juan R. , Benites-Zapata Vicente A.
Published: July 2023

We performed a systematic review and meta-analysis of studies assessing telomere length in blood leukocytes or mononuclear cells in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The review protocol was registered in PROSPERO (CRD42022300950). Searches were conducted in PubMed, Embase, LILACS, CNKI, and Wang Fang, from inception through November 2022. The primary outcomes were maternal and offspring telomere length. The Newcastle-Ottawa Scale was used to assess the quality of included studies. Random-effect meta-analyses were applied to estimate standardized mean differences (SMDs) and their 95% confidence interval (CI). The meta-analysis of four studies showed no significant maternal telomere length difference (SMD = −0.80, 95% CI: −1.66, 0.05) in women with GDM compared to NPW. In the sensibility analysis omitting one study with a small sample of women, the telomere length becomes significantly reduced in women with GDM (SMD = −1.10, 95% CI: −2.18, −0.02). GDM patients had increased glucose (SMD = 0.28, 95% CI: 0.09, 0.46) and glycosylated hemoglobin than NPW (SMD = 0.62, 95% CI: 0.23, 1.01) while total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides did not display differences between women with and without GDM. There was no significant difference in cord blood telomere length in offspring from women with GDM and NPW (SMD = 0.11, 95% CI: −0.52, 0.30). Cord blood insulin levels (SMD = 0.59, 95% CI: 0.33, 0.85) and birthweight (SMD = 0.59, 95% CI: 0.39, 0.79) were higher in offspring from pregnant women with GDM than in those from NPW. There were no significant differences in maternal and offspring telomere length between pregnancies with and without GDM.
Causalgia: A Review of Nerve Resection, Amputation, Immunotherapy, and Amputated Limb CRPS II Pathology
Authors: Watson C. Peter N. , Midha Rajiv , Ng Denise W.
Published: July 2023

Background:

Causalgia and complex regional pain syndrome (CRPS) type II with nerve injury can be difficult to treat. Surgical peripheral nerve denervation for causalgia has been largely abandoned by pain clinicians because of a perception that this may aggravate a central component (anesthesia dolorosa).

Methods:

We selectively searched Pubmed, Cochrane, MEDLINE, EMBASE, CINAHL Plus, and Scopus from 1947 for articles, books, and book chapters for evidence of surgical treatments (nerve resection and amputation) and treatment related to autoimmunity and immune deficiency with CRPS.

Results:

Reviews were found for the treatment of causalgia or CRPS type II (n = 6), causalgia relieved by nerve resection (n = 6), and causalgia and CRPS II treated by amputation (n = 8). Twelve reports were found of autoimmunity with CRPS, one paper of these on associated immune deficiency and autoimmunity, and two were chosen for discussion regarding treatment with immunoglobulin and one by plasma exchange. We document a report of a detailed and unique pathological examination of a CRPS type II affected amputated limb and related successful treatment with immunoglobulin.

Conclusions:

Nerve resection, with grafting, and relocation may relieve uncomplicated causalgia and CRPS type II in some patients in the long term. However, an unrecognized and treatable immunological condition may underly some CRPS II cases and can lead to the ultimate failure of surgical treatments.