bluuebunny/crossref_metadata_2025 huggingface dataset:
Doing Difference: The Bright Side, Dark Side, and Unexpected
Authors: Phipps Marcus , Lu Fang-Chi , Bove Liliana
Published: September 2023

Entities, including organisations, brands and individuals, pursue a strategy of difference (a way to be dissimilar to others) to improve their performance outcomes and well-being. In this editorial, we introduce five research articles and two expert commentaries that examine some aspects of such difference. We further highlight the challenges that consumers face when taking action to meet the goal of difference. Using activity theory and its associated systemic framework, we uncover three contradictions (community, power and knowledge) that manifest as tensions or conflicts as consumers navigate difference. Being aware of these contradictions assists marketers in capitalising on the bright side, preparing for the unexpected and avoiding the dark side of consumers’ efforts towards difference. We also suggest a research agenda to stimulate future scholarship on difference.
Research on nonlinear dynamics and primary resonance characteristics of electric drive gear transmission system for clean propulsion vehicles
Authors: Mo Shuai , Liu Wenbin , Tang Xu , Zhang Wei
Published: September 2023

To study the nonlinear dynamic characteristics of the electric drive transmission system of clean propulsion vehicles, a rotor-bearing system consisting of dual-stage meshing gear pairs and multiple loaded bearings was established. The influence of time-varying meshing stiffness, tooth side clearance, bearing clearance, and other factors were considered. A multi-degree of freedom vibration differential of the system was established equation, to analyze the vibration characteristics of various parts of the transmission system under different parameters. Using time-domain diagrams, poincaré cross-sections, bifurcation diagrams, and other images to study the vibration of gears. In addition, the primary resonance stability equation of the system is derived and its stability under different conditions is analyzed using meshing damping, stiffness, and load as variables. The results show that as the rotational speed increases, the first stage gear of the system undergoes the “single cycle-bifurcation-chaos-bifurcation-single cycle” vibration process, while the second stage gear undergoes two such processes. The instability intervals can be obtained as [3092,4859] and [8098,10896] r/min, [2797,3533] and [9423,14135] r/min respectively. Avoiding these speed ranges helps to improve the stability and safety of automotive motion.
Illustrating Stravinsky: integration of new media design in live Philharmonic Orchestra performance
Authors: Bhutipunthu Dynaya , Konstanz Dale
Published: September 2023

Today, as arts organizations, including philharmonic orchestras, look for new ways to engage their patrons and attract new audiences, the use of new media can enhance experiences at arts venues and events such as concerts, and can lead to greater appreciation of art forms that are sometimes considered outmoded and staid. This study focuses on the search for an appropriate approach, design process and implementation of new media design for symphonic orchestra performance. The case study examines the integration of new media for the Thailand Philharmonic Orchestra’s live performance of The Rite of Spring, an early 20th-century avant-garde masterpiece composed by Igor Stravinsky. Motion graphics and AR technology were utilized to bring hand-drawn and painted elements inspired by the music and Russian folk art to life.
Monsoon as method
Authors: Bremner Lindsay , Cullen Beth , Cane Jonathan , Geros Christina
Published: September 2023

This paper is a reflective discussion of the research method developed by a small research team over a 5-year period as it intra-acted with the south Asian monsoon in three south/southeast Asian cities. It reflects on how the team’s practice was transformed from being research on or about the monsoon as a discrete unit of analysis, to research in the monsoon and with its agential materiality. The paper first outlines the theoretical resources from cultural geography, anthropology, feminist theory, posthuman theory, and science and technology studies that the project drew from. After this theoretical section, the paper then discusses the practical implications of the method and the two emergent strands of research (‘weather matters’ and ‘construction matters’) that were followed in Chennai, Dhaka, and Yangon. The final section of the paper reflects on the extension of the method into the formatting of a book and an online exhibition. The paper concludes by arguing that what the method offers to cultural, weather-based research in monsoonal and other climes, is a situated, non-formulaic method that recognizes the affordances of the Earth’s agency, of matter and of other-than-human lives for generating knowledge of and ways of being in changing weather-worlds.
Incidence and Etiology of Rare Saphenous Nerve Injury After Knee Surgery with Adductor Canal Block: A Retrospective Observational Study
Authors: Like Brian J. , Soffin Ellen M. , Ortolan Sarah , Guheen Carrie R. , Yang Elaine , Sneag Darryl B. , Kramskiy Vladimir N. , Ranawat Anil S. , Beckman James D.
Published: September 2023

Background:

Adductor canal block (ACB) is commonly included in multimodal analgesia regimens for knee surgery. Nonetheless, the incidence, etiology, and procedure-specific risk of saphenous nerve injury after knee surgery with ACB have not been established.

Purpose:

We sought to identify the risk of saphenous nerve injury during knee surgery with ACB.

Methods:

We conducted a retrospective cohort study of patients at a single institution who underwent elective knee surgery with ultrasound-guided ACB between January 1, 2014, and December 31, 2018, and had subsequent saphenous nerve injury. The primary outcome was the incidence of saphenous nerve injury within 3 months of surgery, by surgical type and approach. Secondary outcomes included attribution of the most likely etiology and clinical outcome of the injury.

Results:

In 28,196 cases of knee surgery with ACB, we identified 18 cases (0.06%) of saphenous nerve injury. The most common surgery associated with saphenous nerve injury was anterior cruciate ligament (ACL) reconstruction with autograft (8/18 cases); 3 cases of injury were seen after TKA, 2 after medial patellofemoral ligament reconstruction, 2 after arthroscopy/meniscal surgery, and 1 after patellar fixation. The most likely etiology of nerve injury was attributed to ACB in 5 of 18 cases (28%) and to non-ACB cause in 13 of 18 (72%). Prognosis was rated as unknown in 11 of 18, poor in 2 of 18, favorable in 3 of 18, and full recovery in 2 of 18.

Conclusions:

This 5-year retrospective, single-institution cohort study found a low overall incidence of saphenous nerve injury after knee surgery with ACB, but the injury likelihood varied based on surgery and approach. Although not statistically significant, ACL reconstruction with hamstring autograft and ACB performed for postoperative rescue analgesia were most frequently associated with nerve injury.
Neighborhood Deprivation and Association With Medical Complications, Emergency Department Use, and Readmissions in Shoulder Arthroplasty Patients
Authors: Gordon Adam M. , Sheth Bhavya K. , Conway Charles A. , Horn Andrew R. , Sadeghpour Ramin , Choueka Jack
Published: September 2023

Background:

Social determinants of health are prognostic indicators for patients undergoing orthopedic procedures.

Purpose:

Using the area deprivation index (ADI), a validated, weighted index of material deprivation and poverty (a 0%-to-100% scale, with higher percentages indicating greater disadvantage), we sought to evaluate whether there are associations in shoulder arthroplasty patients between higher ADI and rates of (1) medical complications, (2) emergency department (ED) utilizations, (3) readmissions, and (4) costs.

Methods:

We queried the PearlDiver nationwide database for patients who had undergone primary shoulder arthroplasty from 2010 to 2020. Patients from regions associated with high ADI (95%+) were 1:1 propensity matched to a comparison group by age, sex, and Elixhauser Comorbidity Index. This yielded 49,440 patients in total. Outcomes included 90-day complications, ED utilizations, readmissions, and costs. Logistic regression models computed odds ratios (ORs) of ADI on the dependent variables. P values of < .05 were significant.

Results:

Patients from high ADI regions showed higher rates and odds of complications than those in the comparison group (10.84% vs 9.45%; OR: 1.10), including acute kidney injuries (1.73% vs 1.38%; OR: 1.23), urinary tract infections (3.19% vs 2.80%; OR: 1.13), and respiratory failures (0.49% vs 0.33%; OR: 1.44), but not increased ED visits (2.66% vs 2.71%; OR: 0.99) or readmissions (3.07% vs 2.96%; OR: 1.03). Patients from high ADI regions incurred higher costs on day of surgery ($8251 vs $7337) and at 90 days ($10,999 vs $9752).

Conclusions:

This 10-year retrospective database study found that patients from high ADI regions undergoing primary shoulder arthroplasty had increased rates of all 90-day medical complications, suggesting that measures of social determinants of health could inform health care policy and improve post-discharge care in these patients.
Smaller diameter sheaths are required to safely perform transradial neurointerventions
Authors: Hanaoka Yoshiki , Koyama Jun-ichi , Nakamura Takuya , Kitamura Satoshi , Abe Daishiro , Yamazaki Daisuke , Inomata Yuki , Horiuchi Tetsuyoshi
Published: September 2023

We read with great interest the paper titled “Transradial access with Simmons guiding catheter for carotid artery stenting: Feasibility and procedural complications in a single-center experience” by Muszynski et al. The authors concluded that a transradial carotid artery stenting (CAS) using a Glidesheath Slender 7F Introducer/7F Envoy Simmons 2 catheter system was feasible with a high procedural success rate and low access site complication rate. We completely agree with their conclusions. In this study, large-diameter sheaths were used. Large sheaths increase the risk of developing radial artery spasms. Interventionalists must be aware that radial artery spasm can not only require an access crossover, but can also cause severe access site complications, such as eversion or avulsion of the radial artery, catheter/sheath entrapment, and compartment syndrome. A 6F Simmons guiding sheath has a smaller outer diameter than the Glidesheath Slender 7F Introducer does, and it offers a large-bore working channel compatible with a 10-mm diameter Wallstent and Acculink. Transradial CAS with a 6F Simmons guiding sheath has previously yielded a high procedural success rate without serious access site complications. Nevertheless, we believe that a further decrease in the sheath diameter is required to safely perform transradial neurointerventions in more patients.
Reorientation of the Community-Engaged Research in the Era of COVID-19: Innovative Strategies for Adaptive Capacity Evaluation in the Vietnamese Mekong Delta
Authors: Phan Loan Thi , Jou Sue-Ching , Van Khanh Duong
Published: September 2023

The implementation of Community-engaged research (CenR) has faced many challenges in the context of the COVID-19 pandemic, especially when researchers are based in another part of the country or the world. This paper presents a researcher’s initiative for implementing CenR in partnership with local universities, particularly engaging local students to become part of the communities and bridge the gap between researchers and communities. The project aims to engage local communities working in tourism services in assessing their adaptive capacity (AC) to climate change in the Vietnamese Mekong Delta (VMD). Notably, this study was conducted with the researchers being located in Taiwan while the research area was situated in the VMD. Methods used include field trips, in-depth interviews (IDIs), focus group discussions (FGDs), local workshops, and people participation geographic information system (PPGIS). Two groups of students at Kien Giang University (KGU) and Dong Thap University (DTU) (Vietnam) were involved. The article provides the process of engaging with local students, from searching and selecting them, to obtaining consents, engaging and building trust, training and guiding them in field trips, engaging with local communities, collecting and analyzing data, and developing future projects in those communities. The study offers a novel approach that can be extrapolated in the context of global system crises such as climate change, disasters, or emergency situations in remote areas that often experience limited connectivity with the outside world. By encouraging the creativity of students and researchers, this study promotes the continuity of research efforts even in times of uncertainty and crisis.
Regulatory perspective of cancer drug development: An overview
Authors: Panchal Anurag , Musyuni Pankaj , Aggarwal Geeta
Published: September 2023

Despite the fact postulated that better technology and scientific knowledge will lead to better medical services, the truth is very distinctive. Despite having the most cutting-edge scientific knowledge, America and the majority of Europe ironically have the maximum cancer rates. It shows that using technology and science alone to treat cancer and other diseases is inadequate. Additionally, it is now widely acknowledged that majority of pre-clinical tumour models are insufficient, because more than 95% of substances and molecules that kill cancerous cells in culture or reduce tumours in animals may fail in clinical studies in people. Additionally, the majority of anti-cancer medications which are authorised by regulatory bodies like the FDA have either no impact on survival of cancer patients or may raise by a few months. This is amidst the fact that majority of presently offered chemotherapeutic drugs are very expensive, leading to a lack of affordability.
A sustainable data processing approach using ultraviolet-spectroscopy as a powerful spectral resolution tool for simultaneously estimating newly approved eye solution in the presence of extremely carcinogenic impurity aided with various greenness and whiteness assessment perspectives: Application to aqueous humor
Authors: Attia Khalid A.M. , El-Olemy Ahmed , Abbas Ahmed Emad F. , Eid Sherif M.
Published: September 2023

Drug impurities are now seen as a major threat to drug safety around the world, especially when it comes to carcinogenic impurities. Here, we present the first spectrophotometric approach for the quantification of lignocaine and fluorescein in the presence of 2,6-xylidine, lignocaine’s carcinogenic impurity. The approach depends on overcoming unresolved bands through a data processing strategy employing 10 affordable, simple, and sensitive spectrophotometric methods. Fluorescein analysis (1–16 μg mL−1) was performed using direct ultraviolet spectrophotometry (D0) at 478 nm; then, the ratio subtraction method allowed the removal of interference caused by the fluorescein spectrum. From the resulting ratio spectra, 2,6-xylidine (40–160 μg mL−1) can be efficiently determined at 280 nm. However, lignocaine (72–320 μg mL−1) was analyzed using different ultraviolet-based methods, including continuous wavelet transform, ratio derivative by Savitzky–Golay filters, mean centering, second derivative of ratio spectra, ratio spectra difference spectrophotometry, extended ratio subtraction, absorbance subtraction, Q-absorbance ratio, and area under the curve. In line with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH), the presented approach was evaluated by its coefficients of determination, detection limits, quantification limits, and relative standard deviations. Similarly, the developed approach was assessed for whiteness, greenness, and sustainability using five assessment tools, including National Environmental Method Index, Eco-Scale Assessment, Complementary Green Analytical Procedure Index, Analytical Greenness Metric, and RGB12, offering promising results. Owing to the satisfactory analytical performance, besides the sustainability, affordability, simplicity, and cost efficiency of the presented methods, their application for quality control and in situ analysis in minimal-infrastructure laboratories increases, increasing the surveillance potential.
Violet dyes of the 1860s: Hofmann, Britannia, violet de Paris, Wanklyn’s, and Crystal violet (1883)
Authors: Plater M John , Raab Andrea , Hartmann Horst
Published: September 2023

Two 19th-century historical violet dyes from the Historische Farbstoffsammlung, Technical University of Dresden, have been analysed by liquid chromatography–mass spectrometry (LC-MS). The data are presented as charts with retention time and two scales: electron spray mass spectrometry counts ( m/z) and milli-absorption units (UV). These dyes are complex mixtures as anticipated from the synthetic methods involving partial alkylation of rosaniline or synthesis using mixtures of N-methylaniline and N,N-dimethylaniline. The charts typically show chromophores separated by CH2 units which have separated well. Hofmann’s violet is presumably made by Hofmann’s method of synthesis, but the analyses do not verify with certainty who the inventors are because of the complexity of the dye mixtures.
An audit of CTPA and V/Q scan for investigation of pulmonary embolism in pregnancy
Authors: Ehrlich Romy , Lowe Sandra
Published: September 2023

Background

Pulmonary embolism (PE) can be fatal yet difficult to diagnose in pregnancy. Computed tomography pulmonary angiogram (CTPA) or ventilation/perfusion (V/Q) scans are often conducted, potentially leading to low positive scan rates.

Methods

Retrospective data analysis was conducted for pregnant women and non-pregnant age-matched control who underwent CTPA and/or V/Q scan for investigation of PE. The main outcomes were the positive and non-diagnostic imaging rates.

Results

In total, 440 women underwent V/Q or CTPA scans, 86 of whom were pregnant (19.5%). The positive scan rate was 3.5% and 8.8% in the pregnant and non-pregnant groups, respectively ( p = 0.1). The non-diagnostic scan rate was similar between pregnant and non-pregnant groups (13.9% vs 9.9%, p = 0.3). Within the pregnant group, there were more non-diagnostic CTPAs than V/Q scans ( p = 0.005).

Conclusion

Our study confirms a low positive imaging rate and a relatively high non-diagnostic CTPA rate in pregnancy. Newer strategies are needed to reduce the number of negative imaging studies conducted.
Bioactive Ingredients of Helleborus niger L. (Christmas Rose): The Renaissance of an Old Medicinal Herb—A Review
Authors: Cuny Eckehard
Published: September 2023

The medicinal plant Helleborus nig er L. (Ranunculaceae) found in the European Alps has been valued as an effective remedy for numerous diseases for centuries. Recent preclinical evaluations showed pharmacologic potential of the plant extract for cancer treatment. Furthermore, several compounds extracted from H niger exhibited potent pharmacological effects. Thus, the renaissance of this old and proven medicinal herb requires better knowledge of its bioactive ingredients. A key ingredient of H niger is protoanemonin which is responsible for its burning hot taste and vesicant effect. Protoanemonin possesses antibacterial, antifungal, cytotoxic, and antimutagenic activity, and its isolation, synthesis, and preparation as a therapeutically valuable medicinal product are well elaborated. Anemonin, the dimer of protoanemonin, has antimicrobial, anti-inflammatory, and antimalarial activity, whereas (−)-ranunculin, a protoanemonin glycoside, possesses cytotoxicity and antimutagenic activity. (+)-Ranuncoside, another protoanemonin glycoside, has a spiro acetal molecular scaffold, a feature that is responsible for the biological activity of a multitude of natural products. Furthermore, the flavonoids kaempferol glycoside, quercetin glycoside, and glucosyl-phenyllactic acid have been isolated, and other phenolics with complex structures were detected as well. The main active ingredient of H niger rhizomes is the bufadienolide hellebrin. It is a steroidal cardiac diglycoside with utility for heart failure treatment. Hellebrin and its aglycon hellebrigenin are patented as lead compounds to treat cancer. Recently, additional bufadienolides as well as ecdysteroids were isolated from H niger whole plants and showed potent cytotoxicity on human cancer cell lines. Finally, various saponins have been determined by mass spectrometry, of which 4 compounds isolated from the rhizome are awaiting pharmacological assessment. This review gives an overview of the current knowledge of the isolation, synthesis, structure elucidation, derivatization, and biological activities of known H niger constituents. Furthermore, recent advances concerning the development of pharmaceuticals from these constituents and their derivatives are described.
Serum Cartilage Oligomeric Matrix Protein Concentration Increases More After Running Than Swimming for Older People
Authors: Hay Alexandra M. , Rhoades Madison J. , Bangerter Stephanie , Ferguson Seth A. , Lee Hyunwook , T. Gill Martha , Page Garritt L. , Pope Andrew , Measom Gary J. , Hager Ronald L. , Seeley Matthew K.
Published: September 2023

Background:

Knee osteoarthritis is common in older people. Serum cartilage oligomeric matrix protein (sCOMP) is a biomarker of knee articular cartilage metabolism. The purpose of this study was 2-fold: to (1) determine acute effects of running and swimming on sCOMP concentration in older people; and (2) investigate relationships between sCOMP concentration change due to running and swimming and measures of knee health in older people.

Hypotheses:

Running would result in greater increase in sCOMP concentration than swimming, and increase in sCOMP concentration due to running and swimming would associate positively with measures of poor knee health.

Study Design:

Cross-sectional.

Level of Evidence:

Level 3.

Methods:

A total of 20 participants ran 5 km and 19 participants swam 1500 m. sCOMP concentration was measured immediately before, immediately after, and 15, 30, and 60 minutes after running or swimming. sCOMP concentration change due to running and swimming was compared. Correlations between sCOMP concentration change due to running and swimming, and other measures of knee health were evaluated, including the Tegner Activity Scale and Knee injury and Osteoarthritis Outcome Score.

Results:

sCOMP concentration increased 29% immediately after running, relative to baseline, but only 6% immediately after swimming ( P < 0.01). No significant relationship was observed between acute sCOMP change due to running and swimming, and observed measures of knee health ( P > 0.05). Participants with clinically relevant knee symptoms exhibited greater sCOMP concentration before and after running and swimming ( P = 0.03) and had greater body mass ( P = 0.04).

Conclusion:

Running results in greater acute articular cartilage metabolism than swimming; however, the chronic effects of this are unclear. Older people with clinically relevant knee symptoms possess greater sCOMP concentration and are heavier, independent of exercise mode and physical activity level.

Clinical Relevance:

These results describe the effects of exercise (running and swimming) for older physically active persons, with and without knee pain.
Complete migration of a fully covered self-expandable metallic stent after endoscopic ultrasound-guided hepaticogastrostomy: A case report
Authors: Tomooka Fumimasa , Kitagawa Koh , Mitoro Akira , Motokawa Yuki , Takami Masayoshi , Asada Shohei , Nishimura Norihisa , Ozutsumi Takahiro , Fujinaga Yukihisa , Yoshiji Hitoshi
Published: September 2023

A male patient underwent gastrojejunal bypass surgery in 2017. In 2020, he was referred to our hospital for suspected obstructive jaundice. Subsequently, he was diagnosed with cholangiocarcinoma, and endoscopic retrograde cholangiopancreatography was attempted via balloon-assisted enteroscopy. However, the endoscope did not reach the duodenal papilla owing to the abdomen–small intestine adhesion. Therefore, endoscopic ultrasound-guided hepaticogastrostomy was performed using a dedicated plastic stent. After stent placement, obstructive jaundice and cholangitis promptly improved. However, we replaced the plastic stent with a fully covered self-expandable metal stent because stent occlusions occurred frequently. Two months after fully covered self-expandable metal stent placement, the patient developed cholangitis again. Notably, during the endoscopic procedure, the stent was found to be completely migrated. Nevertheless, the fistula was still open, and the patient was successfully retreated with the maintained fistula of endoscopic ultrasound-guided hepaticogastrostomy.
Managed transparency: Chinese government transparency
Authors: Lee Yunsoo , Sun Zongfeng
Published: September 2023

There are few questions about the fact that China has achieved substantial strides in economic development over the last four decades. Nonetheless, many have cast doubts on its path of increasing transparency. Previous analyses on Chinese transparency have shed light on this issue in isolation. For this reason, we attempt to offer an integrated account of Chinese government transparency. Moreover, transparency involves various dimensions and types. For a complete understanding of transparency, therefore, considering diverse measures is critical. This article aims to provide a condensed overview of government transparency in China by considering various measures of transparency. To a certain extent, China has been successful in bringing greater transparency. Still, in many accounts, it cannot be said that the Chinese government has achieved sufficient progress in promoting transparency.
Satisfaction and Feasibility Evaluation of an Electronic Massager—Expert Manipulative Massage Automation (EMMA): A Pilot Study
Authors: Yang Juan , Croghan Ivana T. , Fokken Shawn C. , Johnson Devan E. , Calva Jason J , Do Alexander , Mueller Michael R. , Bauer Brent A. , Chon Tony Y.
Published: September 2023

Background:

Electronic massagers have gained popularity for their non-invasive and cost-effective approach to healthcare. However, existing electronic massagers require manual manipulation, leading to inconsistency.

Objective:

To investigate the feasibility and acceptability of the Electronic Massager—Expert Manipulative Massage Automation (EMMA) among the American population.

Methods:

A single-arm pilot study was conducted at Mayo Clinic Rochester campus. Participants received massage therapy with the EMMA treatment model and completed a demographics and Satisfaction Survey Questionnaire. Data were collected using REDCap, and statistical analysis was performed.

Results:

Twenty healthy volunteers (13 women, 7 men; median age, 47 years) participated and completed the intervention within 2 weeks. No adverse events were reported. Overall, the acceptability and satisfaction of massage utilizing EMMA were high, with all participants finding the study worthwhile, willing to participate again, and willing to recommend the study to others. Regarding the overall experience, 65.0% reported a better-than-expected experience. Responses to open-ended post-treatment questions showed that most participants enjoyed the warmth (35%), pressure (25%), and relaxation (20%) provided by EMMA, with the majority suggesting no changes or improvements were needed. However, some participants expressed a desire for an expanded massage area (20%).

Conclusions:

This study suggests that the EMMA massager has high acceptability and satisfaction among healthy volunteers, thus demonstrating its feasibility. However, further research is needed to optimize EMMA and assess its clinical effectiveness.
Women’s Configurations of Family, Work, and Education: Mapping Diverse Pathways Throughout Adulthood
Authors: Jane Lee Bo-Hyeong , Manzoni Anna
Published: September 2023

We investigate how women’s family, work, and education statuses are configured over the life course, defining different pathways throughout adulthood. Using data from the National Longitudinal Study of Adolescent and Adult Health, we conduct a repeated measures latent class analysis to explore the various pathways of family, work, and education that women take between their late teens and early forties. Additionally, we investigate the extent to which these pathways vary by race and socioeconomic background. We find seven distinct pathways. In three of the pathways, women are likely to become mothers at an earlier age, but differ in terms of education and work patterns. Three other pathways include women who focus primarily on college in early adulthood, but differ in terms of their work and family patterns. An additional pathway comprises women who remain largely independent while working and continuing education into adulthood. Pathways vary significantly by race, parents’ education, and early family poverty. This study highlights the fluidity of women’s work and educational experiences across adulthood, and articulates significant nuances in the different combinations of women’s family, work, and education across demographic backgrounds.
Magnitude and Predictors of Medication Administration Errors Among Nurses in Public Hospitals in Northeastern Ethiopia
Authors: Gebrye Dagne Belete , Wudu Muluken Amare , Hailu Molla Kassa
Published: September 2023

Introduction

Currently, patient safety and quality of care have become a public health concern. However, medication administration errors are common in global medical settings and may cause problems ranging from the subtle to the fatal.

Objective

To assess the Magnitude and determinant factors of Medication Administration Errors among nurses working in the public hospitals in the Eastern Amhara region, Northeastern Ethiopia, 2022.

Methods

A multicenter hospital-based cross-sectional study design was used in South Wollo Zone public hospitals from February–March 2022, with 423 nurses selected using a simple random method. Data were collected using a pretested questionnaire, entered, and analyzed using EpiData 4.6.0 and SPSS 26. Predictors of medication administration errors were identified by multivariate logistic regression.

Result

Magnitude of Medication Administration Errors in the study areas was 229 (55%), 95% CI [0.501, 0.599]. Service provision to ≥ 11 patients per day (AOR: 2.52, 95% CI [1.187, 6.78]), interruption (AOR: 4.943, 95% CI [2.088, 11.712]), lack of training (AOR: 6.35, 95% CI [3.340, 7.053]), ≥ 4 years and 5–9 years of experience respectively (AOR: 3.802, 95% CI [1.343, 10.763]), (AOR: 2.804, 95% CI [1.062, 7.424]) were factors associated with Medication Error. likewise, shortage of time (AOR: 5.637, 95% CI [2.575, 12.337]), lack of guidelines (AOR: 2.418, 95% CI [1.556, 5.086]), workload (AOR: 7.32, 95% CI [3.146, 17.032]) and stress (AOR: 12.061, 95% CI [33.624, 53.737]) were determinant factors for Medication Administration Errors.

Conclusion and recommendation

In the current study, medication administration errors were common. Patient load, interruption, nurse's service experience, time deficit, stress, a lack of training, and the absence of guidelines were associated with medication administration errors. Therefore, ongoing training, the availability of guidelines, the presence of a good working environment, and the retention of experienced nurses can all be critical steps in improving patient safety.
Associations between neurovascular coupling and cerebral small vessel disease: A systematic review and meta-analysis
Authors: Yang Sheng , Webb Alastair John Stewart
Published: September 2023

Purpose:

The pathogenesis of cerebral small vessel disease (cSVD) remains elusive despite evidence of an association between white matter hyperintensities (WMH) and endothelial cerebrovascular dysfunction. Neurovascular coupling (NVC) may be a practical alternative measure of endothelial function. We performed a systematic review of reported associations between NVC and cSVD.

Methods:

EMBASE and PubMed were searched for studies reporting an association between any STRIVE-defined marker of cSVD and a measure of NVC during functional magnetic resonance imaging, transcranial Doppler, positron emission tomography, near-infrared spectroscopy or single-photon emission computed tomography, from inception to November 3rd, 2022. Where quantitative data was available from studies using consistent tests and analyses, results were combined by inverse-variance weighted random effects meta-analysis.

Findings:

Of 29 studies (19 case-controls; 10 cohorts), 26 reported decreased NVC with increasing severity of cSVD, of which 18 were individually significant. In 28 studies reporting associations with increasing WMH, 25 reported reduced NVC. Other markers of cSVD were associated with reduced NVC in: eight of nine studies with cerebral microbleeds (six showing a significant effect); three of five studies with lacunar stroke; no studies reported an association with enlarged perivascular spaces. Specific SVD diseases were particularly associated with reduced NVC, including six out of seven studies in cerebral amyloid angiopathy and all four studies in CADASIL. In limited meta-analyses, %BOLD occipital change to a visual stimulus was consistently reduced with more severe WMH (seven studies, SMD −1.51, p < 0.01) and increasing microbleeds (seven studies, SMD −1.31, p < 0.01).

Discussion and Conclusion:

In multiple, small studies, neurovascular coupling was reduced in patients with increasing severity of all markers of cSVD in sporadic disease, CAA and CADASIL. Cerebrovascular endothelial dysfunction, manifest as impaired NVC, may be a common marker of physiological dysfunction due to small vessel injury that can be easily measured in large studies and clinical practice.
Ischaemic Stroke After Chronic Subdural Haematoma: An Uncommon Complication in a Common Disease
Authors: Datta Debajyoti , Chatterjee Debarshi
Published: September 2023

Background

Chronic subdural haematoma (CSDH) is a common neurosurgical disease, particularly among the elderly, especially those on antiplatelet or anticoagulation with trivial trauma. While anticoagulants/antiplatelets increase the chance of rebleeding in cases of CSDH, discontinuation may increase the risk of stroke in these patients.

Case Description

We report two cases of CSDH in elderly patients with risk factors who suffered from an ischaemic stroke after undergoing surgery. The first case was an elderly gentleman who had a history of percutaneous coronary intervention, presenting with a CSDH. He developed an anterior cerebral artery infarct in the immediate postoperative period. The second was an elderly gentleman with a history of hypertension presenting with a concomitant left thalamic infarct and large left-sided CSDH. He developed a second middle cerebral artery infarct of the opposite side in the immediate postoperative period.

Conclusion

The medications used for stroke prophylaxis, that is, antiplatelets and anticoagulants are predisposing factors for the development of CSDH. However, the perioperative period of these patients remains vulnerable to the development of new-onset ischaemic stroke.
Suitability of Valuation Methods to E-Commerce Industry – A Case Study
Authors: gupta N N Sen , Sharma Sanjit Lal
Published: September 2023

Today’s business world is witnessing a big revolution in doing business. Now the commerce has a prefix ‘e’ and the market is shifting onto the clouds. With introduction of e-commerce and government inclination towards digital economy, behavioral shift toward internet based transaction has gained momentum. E-commerce or internet based business are now a part of mainstream commerce. The changing way of doing business necessitates adaptation in the way a business is being valued. There are various valuation methods namely Asset based, Earning based and Cash flow based which were used and are also relevant to internet based business, however, consideration required towards new emerging operating indicators. Through this case study we will try to evaluate the popular valuation methods for its suitability to E-commerce based industry where many newly introduced operating indicators such as Gross Merchandise Value (GMV), Customer monetization rate, customer base measuring units Mobile MAUs has impacts on business valuation.
Role of Compressed Biogas to Assess the Effects of Perceived Value on Customer Satisfaction and Customer Loyalty
Authors: Sirothiya Monika , Chavadi Chandan
Published: September 2023

India’s growing economy demands more energy and to sustain this demand, there is an urge to diversify into alternative sources of energy. Compressed biogas (CBG) is a versatile energy source that can replace dependency on fossil fuels. CBG is used in industries or commercial sectors for cooking, heating, power generation, and as a transportation fuel. To effectively market CBG, it is desirable to know customers’ perception of CBG. This study examined the effect of perceived value (functional, social, and convenience) on customer satisfaction. Primary data was gathered from 97 respondents. The list of respondents comprised Business to business (B2B) customers, industrial customers, and commercial customers. The results of the study were analyzed using SPSS and AMOS 24 statistical tools. The findings of this study revealed that each dimension of perceived value affects satisfaction differently and customer satisfaction influenced customer loyalty.
Empirical Scale for Revenge Buying Behaviour: A Curious Consequence of Pandemic
Authors: Malhotra Ms. Suzanee
Published: September 2023

The present paper aims to explain the new phenomenon of revenge buying behaviour witnessed among consumers as an aftermath of the pandemic. This paper also aims to develop and validate a new scale that can empirically measure the revenge buying behaviour. Recommendations and observations made by Churchill in 1979 are used to develop and validate the revenge buying behaviour scale. The factor analysis results indicate empirical evidence for the 13-item revenge buying behaviour scale. The results show that the scale is valid and reliable. Added purchasing power, feel store environment, feel good factor and desire satiation were noted as the four factors forming a part of the empirical scale for the revenge buying behaviour. The study also suggests that people hold special value for ‘in-store’ shopping. This research is among the first to present an empirical scale for the revenge buying behaviour, and it adds value to the domain of consumer buying behaviour post the changes brought in by the pandemic.
Indian Startups (2016–2021): What Lies Ahead?
Authors: Das Khanindra Ch.
Published: September 2023

Startup India, which was launched in January 2016, completed five years in January 2022. To mark this occasion, January 16 has been declared as the National Startup Day, starting from 2022. Startup India has made a few significant strides in the preceding five years. We highlight 10 key features of the Indian startup ecosystem followed by a few grey areas where the startup community, academic fraternity, and policy making institutions could pay specific attention.
Women Leaders in the Insurance Sector
Authors: Sinha Saloni
Published: September 2023

This is an interview of Ms. Sathya Saran, the author of Being Ritu: The Unforgettable Story of Ritu Nanda, which is aimed at highlighting the role of women leaders in the insurance sector.
Narsarsukite in peralkaline granites from the Papanduva Pluton, Graciosa Province, south Brazil: Insights from textural and compositional features
Authors: Vlach Silvio R.F. , Vilalva Frederico C.J.
Published: September 2023

We report textural and compositional data for the titanosilicate narsarsukite [Na2(Ti,Fe3+)Si4(O,F)11] in peralkaline granites from the Papanduva Pluton in Graciosa Province, south-southeastern Brazil. Two distinct narsarsukite generations, one late magmatic and the other post-magmatic, were identified on the basis of textural and compositional features. The magmatic generation consists of larger, euhedral to subhedral variably zoned crystals and late poikilitic intergrowths between narsarsukite and albite laths, representing the crystallisation of the latest melt pockets. The post-magmatic generation forms smaller, typically fibrous crystals and irregular aggregates that occur interstitially or replace the primary mafic minerals, particularly arfvedsonite. Compositions of narsarsukite from the Papanduva Pluton cover most of the compositional range described in known occurrences. The magmatic generation is enriched in Zr and depleted in Al. The Fe3+ and Al contents show a positive correlation for the magmatic crystals, but a negative correlation for the post-magmatic narsarsukite. The Al/Fe3+ ratios are higher in the post-magmatic crystals and can be used to discriminate between the two generations. The compositional variations are controlled mainly by the heterovalent substitution (Ti, Zr)4+ + O2– = (Al, Fe)3+ + F1–, and are compatible with (OH)1– ions in the O site. Narsarsukite has significantly higher concentrations of mid REE+Y and HFSE and very low to absent contents of LREE and LILE relative to the host-rocks. The average REE pattern of the magmatic crystals is highly fractionated, consistent with the expected strong preference for the smaller HREE. The post-magmatic crystals that replace arfvedsonite have flatter patterns, with higher concentrations of LREE and MREE. Their compositions suggest a fluid phase relatively rich in HFSE, REE, Y, Pb, Th and U. Narsarsukite is a common phase in strongly peralkaline granites such as the Papanduva Pluton and the well-known Strange Lake Complex, and should be considered a diagnostic mineral of highly peralkaline SiO2-oversaturated rocks containing rare Ti and Zr mineral assemblages.
Hemostasis defects underlying the hemorrhagic syndrome caused by mammarenaviruses in a cynomolgus macaque model
Authors: Lafoux Blaise , Baillet Nicolas , Picard Caroline , Fourcaud Gustave , Borges-Cardoso Virginie , Reynard Stéphanie , Journeaux Alexandra , Germain Clara , Perthame Emeline , Mateo Mathieu , Hortion Jimmy , Carnec Xavier , Pietrosemoli Natalia , Moroso Marie , Lacroix Orianne , Jourjon Ophélie , Barron Stéphane , Vallve Audrey , Duthey Aurélie , Jacquot Frédéric , Barrot Laura , Dirheimer Manon , Raoul Hervé , Nougier Christophe , Baize Sylvain
Published: September 2023

Viral hemorrhagic fevers (HF) are a group of acute febrile diseases with high mortality rates. Although hemostatic dysfunction appears to be a major determinant of the severity of the disease, it is still unclear what pathogenic mechanisms lead to it. In clinical studies it is found that arenaviruses, such as Lassa, Machupo, and Guanarito viruses cause HF that vary in symptoms and biological alterations. In this study we aimed to characterize the hemostatic dysfunction induced by arenaviral HF to determine its implication in the severity of the disease and to elucidate the origin of this syndrome. We found that lethal infection with Machupo, Guanarito, and Lassa viruses is associated with cutaneomucosal, cerebral, digestive, and pulmonary hemorrhages. The affected animals developed a severe alteration of the coagulation system, which was concomitant with acute hepatitis, minor deficit of hepatic factor synthesis, presence of a plasmatic inhibitor of coagulation, and dysfunction of the fibrinolytic system. Despite signs of increased vascular permeability, endothelial cell infection was not a determinant factor of the hemorrhagic syndrome. There were also alterations of the primary hemostasis during lethal infection, with moderate to severe thrombocytopenia and platelet dysfunction. Finally, we show that lethal infection is accompanied by a reduced hematopoietic potential of the bone marrow. This study provides an unprecedented characterization of the hemostasis defects induced by several highly pathogenic arenaviruses.
Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response
Authors: Hurwitz Stephanie N. , Jung Seul K. , Kobulsky Danielle R. , Fazelinia Hossein , Spruce Lynn A. , Pérez Empar Baltasar , Groen Nathalie , Mesaros Clementina , Kurre Peter
Published: September 2023

Hematopoietic stem and progenitor cell (HSPC) transplantation serves as a curative therapy for many benign and malignant hematopoietic disorders and as a platform for gene therapy. However, growing needs for ex vivo manipulation of HSPC-graft products are limited by barriers in maintaining critical self-renewal and quiescence properties. The role of sphingolipid metabolism in safeguarding these essential cellular properties has been recently recognized, but not yet widely explored. Here, we demonstrate that pharmacologic and genetic inhibition of neutral sphingomyelinase 2 (nSMase-2) leads to sustained improvements in long-term competitive transplantation efficiency after ex vivo culture. Mechanistically, nSMase-2 blockade activates a canonical integrated stress response (ISR) and promotes metabolic quiescence in human and murine HSPCs. These adaptations result in part from disruption in sphingolipid metabolism that impairs the release of nSMase-2–dependent extracellular vesicles (EVs). The aggregate findings link EV trafficking and the ISR as a regulatory dyad guarding HSPC homeostasis and long-term fitness. Translationally, transient nSMase-2 inhibition enables ex vivo graft manipulation with enhanced HSPC potency.
An approach for proteins and their encoding genes synonyms integration based on protein ontology
Authors: Wang Xiaohong , Jing Xiaoli , Dou Fangkun , Cao Haowei
Published: September 2023

Background

Biological research is generating high volumes of data distributed across various sources. The inconsistent naming of proteins and their encoding genes brings great challenges to protein data integration: proteins and their coding genes usually have multiple related names and notations, which are difficult to match absolutely; the nomenclature of genes and proteins is complex and varies from species to species; some less studied species have no nomenclature of genes and proteins; The annotation of the same protein/gene varies greatly in different databases. In summary, a comprehensive set of protein/gene synonyms is necessary for relevant studies.

Results

In this study, we propose an approach for protein and its encoding gene synonym integration based on protein ontology. The workflow of protein and gene synonym integration is composed of three modules: data acquisition, entity and attribute alignment, attribute integration and deduplication. Finally, the integrated synonym set of proteins and their coding genes contains over 128.59 million terminologies covering 560,275 proteins/genes and 13,781 species. As the semantic basis, the comprehensive synonym set was used to develop a data platform to provide one-stop data retrieval without considering the diversity of protein nomenclature and species.

Conclusion

The synonym set constructed here can serve as an important resource for biological named entity identification, text mining and information retrieval without name ambiguity, especially synonyms associated with well-defined species categories can help to study the evolutionary relationships between species at the molecular level. More importantly, the comprehensive synonyms set is the semantic basis for our subsequent studies on Protein–protein Interaction (PPI) knowledge graph.