bluuebunny/crossref_metadata_2025 huggingface dataset:
Family Business at Dun Emer and Cuala
Authors: Bergmann Loizeaux Elizabeth
Published: July 2023

This chapter explores collaboration at the Irish craft cooperative Dun Emer (later Cuala) Industries, co-founded by William Butler Yeats’s sisters Elizabeth Corbet Yeats (Lolly) and Susan Mary Yeats (Lily). Lily ran the embroidery division, Lolly the hand press, with W. B. Yeats as literary editor. Clashing personalities and gender dynamics made for contentious relations, especially among these three siblings. Nevertheless, out of their collaboration came WBY’s emergence as a modern poet, the establishment of Dun Emer/Cuala Press as one of the most important fine printing presses of the twentieth century, and Lily’s underappreciated, distinctive embroideries. The collaboration of WBY with Lolly on his volume of poems In the Seven Woods (1903), the press’s first book, and the collaboration of WBY with Lily in the 1930s on embroidered illustrations to his poems demonstrate the remarkable creativity that flourished despite, and perhaps at times sharpened by, the contention in a family business that ran from 1902 to 1986.
The Writings of Jack Yeats
Authors: Allen Nicholas
Published: July 2023

The particularities of Jack Yeats’s formation in a late imperial world shaped by the intimate attachments of his family to a migrant Ireland of the west coast and sea anchor his art in contexts that are obscure to any reader since. This chapter draws some of the coordinates by which the literary works might be approached, through attention to form, sequence, and the suggestive correspondence of memory with time and event. Thinking about how these coordinates might apply to larger questions again, of modernism, literature, history, and perhaps of ideas of Ireland itself, suggests the necessity of reading Jack Yeats’s literary works, which are themselves part of a wider network of aesthetic experiments that attend and shape the fragmentation of the late British imperial world into broken forms of still uncertain meaning.
Illustrating Yeats
Authors: Quin Jack
Published: July 2023

This chapter discusses the illustration of Yeats’s poetry and prose across his writing life as he moved publishers from Charles Kegan Paul to T. Fisher Unwin, to the Cuala Press, and to Macmillan. Yeats revised and refined his aesthetic preferences from photomechanically reproduced narrative paintings to Celtic interlace designs, symbolist flora and fauna to line work inspired by Byzantine mosaics, and abstract, geometrical renderings that aligned with his mythography of gyres and historical cycles. The chapter begins with Yeats’s earliest illustrated poems for magazines decorated by his brother, Jack Yeats, before turning to the poet’s more sustained collaboration with Althea Gyles for Unwin book covers at the turn of century, including The Secret Rose. The third section discusses the minimalist decorative aesthetic of Dun Emer and the Cuala Press, and the extent to which Yeats favoured a more restrained and uniform design identity to his books in later years. The fourth section traces Yeats’s correspondence and collaboration with Norah McGuinness and T. Sturge Moore on some of his most iconic book covers for Macmillan. His growing interest in geometry and the aesthetics of Byzantine mosaics in the 1920s inform several of these covers, including The Tower, The Winding Stair, and the Stories of Red Hanrahan and the Secret Rose. With the selection of new artists and livery to cover old books, illustration afforded Yeats an opportunity to step backwards in history to an abstract or symbolic phase of art that was antiquated and yet strikingly modern and refreshing.
Playing Yeats
Authors: Lonergan Patrick
Published: July 2023

If there is a tradition of staging W. B. Yeats’s plays, it is one in which successive generations discover his work as if no one has ever done so before: the plays are performed, sometimes with reverence but often with a healthily iconoclastic commitment to experimentation; they are well received, prompting questions about why they are not better appreciated—and then they are forgotten, until the pattern begins again. The purpose of this chapter, therefore, is not just to trace the production history of Yeats’s drama but also to consider why those isolated moments have never coalesced into a distinctive tradition.
Yeats and Contemporary Poetry
Authors: Groarke Vona
Published: July 2023

In the preface to this volume, The Oxford Handbook of W. B. Yeats, the editors posed Yeats’s question, via Plato’s ghost, ‘What then?’ This chapter offers ‘Twelve Speculative Takes’ in answer to the question ‘What now?’ How do we read Yeats in light of the preoccupations of contemporary poetry? How do we vivify Yeats in the environmental turn; the revolt against form; the twenty-first-century media; the wake of MeToo; the nationalism that co-opts his work; the twenty-first-century academy; litigation culture; the institutionalization of creativity; a pervasive climate of buzzwords and advertising? As an epilogue to the Handbook, these speculative takes prompt us to ask, ‘What next?’
The Arabidopsis F-box protein SKP1-INTERACTING PARTNER 31 modulates seed maturation and seed vigor by targeting JASMONATE ZIM DOMAIN proteins independently of jasmonic acid-isoleucine
Authors: Varshney Vishal , Hazra Abhijit , Rao Venkateswara , Ghosh Shraboni , Kamble Nitin Uttam , Achary Rakesh Kumar , Gautam Shikha , Majee Manoj
Published: July 2023

F-box proteins have diverse functions in eukaryotic organisms, including plants, mainly targeting proteins for 26S proteasomal degradation. Here, we demonstrate the role of the F-box protein SKP1-INTERACTING PARTNER 31 (SKIP31) from Arabidopsis (Arabidopsis thaliana) in regulating late seed maturation events, seed vigor, and viability through biochemical and genetic studies using skip31 mutants and different transgenic lines. We show that SKIP31 is predominantly expressed in seeds and that SKIP31 interacts with JASMONATE ZIM DOMAIN (JAZ) proteins, key repressors in jasmonate (JA) signaling, directing their ubiquitination for proteasomal degradation independently of coronatine/jasmonic acid-isoleucine (JA-Ile), in contrast to CORONATINE INSENSITIVE 1, which sends JAZs for degradation in a coronatine/JA-Ile dependent manner. Moreover, JAZ proteins interact with the transcription factor ABSCISIC ACID-INSENSITIVE 5 (ABI5) and repress its transcriptional activity, which in turn directly or indirectly represses the expression of downstream genes involved in the accumulation of LATE EMBRYOGENESIS ABUNDANT proteins, protective metabolites, storage compounds, and abscisic acid biosynthesis. However, SKIP31 targets JAZ proteins, deregulates ABI5 activity, and positively regulates seed maturation and consequently seed vigor. Furthermore, ABI5 positively influences SKIP31 expression, while JAZ proteins repress ABI5-mediated transactivation of SKIP31 and exert feedback regulation. Taken together, our findings reveal the role of the SKIP31-JAZ-ABI5 module in seed maturation and consequently, establishment of seed vigor.
Lipoxin A4 promotes antibiotic and monocyte bacterial killing in established Pseudomonas aeruginosa biofilm formed under hydrodynamic conditions
Authors: Thornton Julianne M. , Padovani Cristina M. , Rodriguez Ana , Spur Bernd W. , Yin Kingsley
Published: July 2023

Pseudomonas aeruginosa is a gram‐negative, opportunistic bacteria commonly found in wounds and in lungs of immunocompromised patients. These bacteria commonly form biofilms which encapsulate the bacteria, making it difficult for antibiotics or immune cells to reach the bacterial cells. We previously reported that Lipoxin A4 (LxA4), a Specialized Pro‐resolving Mediator, has direct effects on P. aeruginosa where it reduced biofilm formation and promoted ciprofloxacin antibiotic efficacy in a static biofilm‐forming system. In the current studies, we examined the actions of LxA4 on established biofilms formed in a biofilm reactor under dynamic conditions with constant flow and shear stress. These conditions allow for biofilm growth with nutrient replenishment and for examination of bacteria within the biofilm structure. We show that LxA4 helped ciprofloxacin reduction of live/dead ratio of bacteria within the biofilm. THP‐1 monocytes interacted with the biofilm to increase the number of viable bacteria within the biofilm as well as TNF‐α production in the biofilm milieu, suggesting that monocyte interaction with bacterial biofilm exacerbates the inflammatory state. Pre‐treatment of the THP‐1 monocytes with LxA4 abolished the increase in biofilm bacteria and reduced TNF‐α production. The effect of decreased biofilm bacteria was associated with increased LxA4‐induced monocyte adherence to biofilm but not increased bacteria killing suggesting that the mechanism for the reduced biofilm bacteria was due to LxA4‐mediated increase in adherence to biofilm. These results suggest that LxA4 can help antibiotic efficacy and promote monocyte activity against established P. aeruginosa biofilm formed under hydrodynamic conditions.
SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
Authors: Luo Yuanyuan , Zhou Shuaishuai , Xu Tao , Wu Wanling , Shang Pingping , Wang Shuai , Pan Defeng , Li Dongye
Published: July 2023

Background:

Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is a key protein that maintains myocardial Ca2+ homeostasis. The present study aimed to investigate the mechanism underlying the SERCA2a-SUMOylation (small ubiquitin-like modifier) process after ischemia/reperfusion injury (I/RI) in vitro and in vivo.

Methods:

Calcium transient and systolic/diastolic function of cardiomyocytes isolated from Serca2a knockout (KO) and wild-type mice with I/RI were compared. SUMO-relevant protein expression and localization were detected by quantitative real-time PCR (RT-qPCR), Western blotting, and immunofluorescence in vitro and in vivo. Serca2a-SUMOylation, infarct size, and cardiac function of Senp1 or Senp2 overexpressed/suppressed adenovirus infected cardiomyocytes, were detected by immunoprecipitation, triphenyltetrazolium chloride (TTC)-Evans blue staining, and echocardiography respectively.

Results:

The results showed that the changes of Fura-2 fluorescence intensity and contraction amplitude of cardiomyocytes decreased in the I/RI groups and were further reduced in the Serca2a KO + I/RI groups. Senp1 and Senp2 messenger ribose nucleic acid (mRNA) and protein expression levels in vivo and in cardiomyocytes were highest at 6 h and declined at 12 h after I/RI. However, the highest levels in HL-1 cells were recorded at 12 h. Senp2 expression increased in the cytoplasm, unlike that of Senp1. Inhibition of Senp2 protein reversed the I/RI-induced Serca2a-SUMOylation decline, reduced the infarction area, and improved cardiac function, while inhibition of Senp1 protein could not restore the above indicators.

Conclusion:

I/RI activated Senp1 and Senp2 protein expression, which promoted Serca2a-deSUMOylation, while inhibition of Senp2 expression reversed Serca2a-SUMOylation and improved cardiac function.
Increase in Newborns Ventilated Within the First Minute of Life and Reduced Mortality After Clinical Data-Guided Simulation Training
Authors: Vadla May Sissel , Mduma Estomih Raphael , Kvaløy Jan Terje , Mdoe Paschal , Hhoki Barikiel Hhando , Sarangu Sabrina , Michael Paskalina , Oftedal Bjørg , Ersdal Hege
Published: July 2023

Introduction

Birth asphyxia–related deaths is a major global concern. Rapid initiation of ventilation within the “Golden Minute” is important for intact survival but reported to be challenging, especially in low-/middle-income countries. Helping Babies Breathe (HBB) is a simulation-based training program for newborn resuscitation. The aim of this HBB quality improvement (QI) intervention was to decrease time from birth to ventilation and document potential changes in perinatal outcomes.

Method

Prospective observational QI study in a rural Tanzanian hospital, October 1, 2017, to August 31, 2021, first-year baseline, second-year QI/simulation intervention, and 2-year postintervention. Trained research assistants observed wide-ranging information from all births (N = 12,938). The intervention included monthly targeted HBB simulation training addressing documented gaps in clinical care, clinical debriefings, and feedback meetings.

Results

During the QI/simulation intervention, 68.5% nonbreathing newborns were ventilated within 60 seconds after birth compared with 15.8% during baseline and 42.2% and 28.9% during the 2 postintervention years (P < 0.001). Time to first ventilation decreased from median 101 (quartiles 72–150) to 55 (45–67) seconds (P < 0.001), before increasing to 67 (49–97) and 85 (57–133) seconds after intervention. More nonbreathing newborns were ventilated in the intervention period (12.9%) compared with baseline (8.5%) and the postintervention years (10.6% and 9.4%) (P < 0.001). Assumed fresh stillborns decreased significantly from baseline to intervention (3.2%–0.7%) (P = 0.013).

Conclusions

This QI study demonstrates an increase in nonbreathing newborns being ventilated within the Golden Minute and a significant reduction in fresh stillborns after introduction of an HBB QI/simulation intervention. Improvements are partially reversed after intervention, highlighting the need for continuous simulation-based training and research into QI efforts essential for sustainable changes.
Alec Grant: a living tribute
Authors: Carson Jerome
Published: July 2023

Purpose

This paper aims to provide a living tribute to the leading autoethnographer, Alec Grant.

Design/methodology/approach

Alec provided Jerome with a list of names of people he might approach to write a tribute on his behalf.

Findings

The accounts describe the influence that Alec has had both as an educator and as a trusted colleague for the people approached.

Research limitations/implications

While this is a living tribute, it is about one man and could, therefore, be described as a case study. Some people wonder what can be learned from a single case study. Read on and find out.

Practical implications

Alec has carved out a path for himself. In many senses, he chose “The Road Less Travelled”. He has never shied away from challenging “The System” and defending the rights of the marginalized and socially excluded. It is not a road for the faint-hearted.

Social implications

For systems to change, radical thinkers need to show the way. “Change keeps us safe” (Stuart Bell).

Originality/value

Alec was a well-known and highly respected cognitive behavioural academic practitioner and the author of key textbooks in the field. He then decided to reinvent himself as an autoethnographer. This has brought him into contact with a much more diverse group of people. It has also brought him home to himself.
Precise determination of initial printable time for cement mortar 3D printing using a derivative method
Authors: Sukontasukkul Piti , Maho Buchit , Komkham Sila , Pianfuengfoo Satharat , Zhang Hexin (Johnson) , Yoo Doo-Yeol , Tangchirapat Weerachart , Sae-Long Worathep , Limkatanyu Suchart , Chindaprasirt Prinya
Published: July 2023

Purpose

This study aims to propose a technique that establishes a mathematical relationship between width and time, and utilizes a derivative method to determine the initial printable time (tint) for mortar suitable for 3D printing. The study conducted experimental tests on the tint, layer strain, and the relationship between filament width and time. These tests involved plain mortar and mortar reinforced with micro-fibers at varying volume fractions. The tint was determined analytically using the derivative method.

Design/methodology/approach

This study introduces a technique to accurately determine the initial printable time (tint) and width/height of printed cement mortar. Precise tint determination is essential for ensuring proper filament printing timing and eliminating the need for trial and error.

Findings

Results show that the proposed technique accurately determines the tint, as evidenced by the resemblance between expected and actual initial widths. Fiber-reinforced mortar (FRM) has a smaller tint than plain mortar, which decreases with an increasing fiber content. Additionally, FRM displays smaller layer strains compared to plain mortar.

Research limitations/implications

Results show that the proposed technique accurately determines the tint, as evidenced by the resemblance between expected and actual initial widths. FRM exhibits smaller tint and displays smaller layer strains than plain mortar.

Originality/value

This study introduces a novel technique that uses a mathematical relationship to determine the tint and height of cement mortar printing.
Percentage of low attenuation area on computed tomography detects chronic lung allograft dysfunction, especially bronchiolitis obliterans syndrome, after bilateral lung transplantation
Authors: Kubo Yujiro , Sugimoto Seiichiro , Shiotani Toshio , Matsubara Kei , Hashimoto Kohei , Tanaka Shin , Shien Kazuhiko , Suzawa Ken , Miyoshi Kentaroh , Yamamoto Hiromasa , Okazaki Mikio , Toyooka Shinichi
Published: July 2023

Introduction

The percentage of low attenuation area (%LAA) on computed tomography (CT) is useful for evaluating lung emphysema, and higher %LAA was observed in patients with chronic lung allograft dysfunction (CLAD). This study investigated the relationship between the %LAA and the development of CLAD after bilateral lung transplantation (LT).

Methods

We conducted a single‐center retrospective study of 75 recipients who underwent bilateral LT; the recipients were divided into a CLAD group (n = 30) and a non‐CLAD group (n = 45). The %LAA was calculated using CT and compared between the two groups from 4 years before to 4 years after the diagnosis of CLAD. The relationships between the %LAA and the percent baseline values of the pulmonary function test parameters were also calculated.

Results

The %LAA was significantly higher in the CLAD group than in the non‐CLAD group from 2 years before to 2 years after the diagnosis of CLAD (P < .05). In particular, patients with bronchiolitis obliterans syndrome (BOS) exhibited significant differences even from 4 years before to 4 years after diagnosis (P < .05). Significant negative correlations between the %LAA and the percent baseline values of the forced expiratory volume in 1 s (r = −.36, P = .0031), the forced vital capacity (r = −.27, P = .027), and the total lung capacity (r = −.40, P < .001) were seen at the time of CLAD diagnosis.

Conclusion

The %LAA on CT was associated with the development of CLAD and appears to have the potential to predict CLAD, especially BOS, after bilateral LT.
A complex intervention to support breastfeeding: A feasibility and acceptability study
Authors: Lucchini‐Raies Camila , Marquez‐Doren Francisca , Perez J. Carola , Campos Solange , Beca Paulina , Lopez‐Dicastillo Olga
Published: July 2023

Aims

The aims of this study are to assess the acceptability and feasibility of a multicomponent intervention to support breastfeeding women and their families and explore its effectiveness.

Methods

A pilot study with control and intervention groups was conducted using the complex intervention framework in two primary healthcare centres. Overall, 44 childbearing women, their partners/relatives and 20 healthcare professionals participated in the study. The intervention's feasibility and acceptability were measured. The percentage of exclusive breastfeeding rates and women's self‐efficacy were measured at pre‐intervention, at 10 days postpartum, and again at 2, 4 and 6 months postpartum. Postpartum depression risk was measured at 2 and 6 months postpartum. Professional self‐efficacy was measured at pre‐intervention and 3 months later.

Results

The intervention was feasible and acceptable. No difference in self‐efficacy existed between the intervention and control groups. Preliminary effects of the intervention were found in exclusive breastfeeding percentage and postpartum depression risk in the intervention group.

Conclusion

The intervention is feasible and acceptable. The results are promising not only for breastfeeding maintenance but also for preventing postpartum depression and recovering exclusive breastfeeding during pandemics.

Trial registration

ClinicalTrials.gov ID: NCT03944642.
Infant colic and abdominal pain; associations with infant multimorbidity and maternal perceived stress up to 3 months postpartum—A cross‐sectional/cohort study in the PreventADALL study
Authors: Despriee Åshild Wik , Småstuen Milada Cvancarova , Glavin Kari , Lødrup Carlsen Karin C. , Magi Caroline Aleksi Olsson , Söderhäll Cilla , Hedlin Gunilla , Nordhagen Live , Jonassen Christine M. , Rehbinder Eva Maria , Nordlund Björn , Skjerven Håvard
Published: July 2023

Aims and Objectives

The primary aim was to explore whether infants with pain symptoms (colic, abdominal pain and visit to healthcare provider with pain or other discomforts) had increased multimorbidity (common infections, eczema and food sensitivity) compared with infants without these conditions. Secondarily, we aimed to determine whether infant pain symptoms were associated with maternal perceived stress in pregnancy and 3 months postpartum.

Background

Infant colic and abdominal pain are common concerns in early infancy. Nevertheless, to our knowledge, little research exists on the relationship between infant pain and common infant infections, eczema and food sensitization as comorbidities, and the impact of infant pain on the development of maternal perceived stress from pregnancy to infancy is inconsistent.

Design

This study was cross‐sectional and partly prospective.

Methods

The sample consisted of mother–infant pairs (N = 1852); information regarding infant pain and multimorbidity was collected from the 3‐month questionnaire and postpartum visits in the PreventADALL prospective cohort study. Chi‐square tests and regression analyses were conducted. The STROBE checklist was followed.

Results

Our results showed a statistically significant higher proportion of respiratory and other infections in infants with pain symptoms. The odds of infant pain were higher for infants with multimorbidity compared to those with no comorbidity. Mothers of infants with colic and of infants visiting healthcare with pain and other discomforts reported statistically significant higher perceived stress by 3 months compared with mothers of infants with no reported pain.

Conclusion

Our results indicate an association between infant pain symptoms and the presence of infections. Mothers of infants with colic and visiting healthcare had higher perceived stress compared to the no pain group.

Implications for Practice

Our study indicates that infant pain is associated with infant multimorbidity and maternal perceived stress, which may be useful when planning diagnostic, treatment and coping strategies in infant and family care.

Patient or Public Contribution

The PreventADALL is a collaborative study with governmental and patient organisation representation. Selected infants with parents were also contributing during calibrating courses on eczema assessment for the data collectors.

Trial Registration

The study was approved by the Regional Committee in Norway (2014/518) and Sweden (2014/2242–31/4) and registered at clinicaltrial.gov (NCT02449850). Link for clinical trials: https://clinicaltrials.gov/ct2/show/NCT02449850
Spatial Migration Experience and Turnover Intention: Empirical Evidence from Japan
Authors: Wang Jian , Chen Xueting , Sun Furong , Qian Xuepeng
Published: July 2023

Migration experience has a profound impact on psychological health and well‐being, but relatively little is known about how spatial relocation affects turnover intention in the labor market. This study attempted to examine the effects of spatial migration experience on turnover intention. Using individual‐level survey data on people's migration experience and career development from Japan, we verified the central hypothesis that internal migration has positive effects on later turnover intention by employing both linear and ordered probit regressions. Further, several robustness checks were conducted in order to address endogeneity issues. We first corrected for the self‐selection bias in two ways, adding the number of companies worked for as a control variable to partly capture the individual psychological factors and estimating with the treatment effects model. Then a sub‐sample regression was used to eliminate the bias from active migration due to job change. All confirmed the positive effect of migration experience on turnover intention.
HLA variants and TCR diversity against SARS‐CoV‐2 in the pre‐COVID‐19 era
Authors: Buhler Stéphane , Sollet Zuleika Calderin , Bettens Florence , Schäfer Antonia , Ansari Marc , Ferrari‐Lacraz Sylvie , Villard Jean
Published: July 2023

HLA antigen presentation and T‐cell mediated immunity are critical to control acute viral infection such as COVID‐19 caused by SARS‐CoV‐2. Recent data suggest that both the depth of peptide presentation and the breadth of the T‐cell repertoire are associated with disease outcome. It has also been shown that unexposed subjects can develop strong T‐cell responses against SARS‐CoV‐2 due to heterologous immunity. In this study, we explored the anti‐SARS‐CoV‐2 T‐cell repertoire by analyzing previously published T‐cell receptor (TCR) CDR3β immunosequencing data in a cohort of 116 healthy donors and in the context of immune reconstitution after allogeneic hematopoietic stem cell transplantation in 116 recipients collected during the pre‐COVID‐19 era. For this, 143,310 publicly available SARS‐CoV‐2 specific T‐cell sequences were investigated among the 3.5 million clonotypes in the cohort. We also performed HLA class I peptide binding predictions using the reference proteome of the virus and high resolution genotyping data in these patients. We could demonstrate that individuals are fully equipped at the genetic level to recognize SARS‐CoV‐2. This is evidenced by the 5% median cumulative frequency of clonotypes having their sequence matched to a SARS‐CoV‐2 specific T‐cell. In addition, any combination of HLA class I variants in this cohort is associated with a broad capacity of presenting hundreds of SARS‐CoV‐2 derived peptides. These results could be explained by heterologous immunity and random somatic TCR recombination. We speculate that these observations could explain the efficacy of the specific immune response against SARS‐CoV‐2 in individuals without risk factors of immunodeficiency and infected prior to vaccination.
Research on Two-Level Equalization Strategy of Lithium-Ion Battery Based on Graph Theory
Authors: Wu Tiezhou , Li Houjia , Li Hongguang , Zhao Rui
Published: July 2023

To solve the problem of inconsistency in the use of series-connected lithium-ion battery packs, this paper proposed a topological structure of dual-layer equalization based on a flying capacitor circuit and Cuk circuit, as well as a control strategy seeking the shortest equalization path. In this structure, batteries are divided into two forms: intra-group and inter-group; the intra-group equalization is the lower-level equalization while the flying capacitor circuit is used as an equalization circuit to achieve equalization between individual battery cells; and the inter-group equalization is the upper-level equalization while Cuk circuit is used as equalization circuit to achieve equalization between battery packs; each battery pack shares a battery cell, thus to obtain more options on equalization path. The proposed strategy, with state of charge as the balancing variable, represents the topological structure of the circuit in the form of graph by adopting graph theory control, seeks the optimal equalization path via ant colony optimization algorithm with global search, thus to improve the equalization speed and efficiency. At last, the structure and the strategy proposed in this paper were simulated in matlab/simulink to compare with the maximum value equalization method in the condition of static, charging, and discharging. The result of the simulation experiments shows that the equalization method based on graph theory control reduces the equalization duration by approximately 17%, and improves the equalization efficiency by approximately 2%, which verifies the superiority and effectiveness of the structure and strategy proposed in this paper.
NDE Requirements of ASME V
Authors: Matthews Clifford
Published: July 2023

NDE is covered in each ICP BoK in four separate areas: the core inservice API code itself; the construction ‘application’ code; ASME V; and API RP 577. These complement each other to complete the full picture. The split is well defined and follows the same pattern in all three BoKs (Table 11.1 shows an example from API 510 ICP).
Introduction to API 570
Authors: Matthews Clifford
Published: July 2023

API 570 is the widest and least specialized of the ICPs. Piping comes in many forms and sizes and there’s a lot of it; up to 20 000 km in some plants. The API 570 Effectivity List (see Chapter 3 of this book) includes publications that cover flanges, valves and other fittings that make up a piping system. The BoK has recently been widened to cover parts of API RP 576 Inspection of Pressure-Relieving Devices, aligning it with API 510. Owing to its wide applicability, API 570 is often the first ICP certificate attempted by candidates. The piping construction code, ASME B31.3, is easier to understand than ASME VIII-I for vessels and the back-up technical information in API RP 574 is less refinery-process specific than the equivalent for vessels, API RP 572, so it’s easier to understand without refinery experience.
ASME B31.3 Process Piping
Authors: Matthews Clifford
Published: July 2023

This chapter explains the role of ASME B31.3 ‘Process Piping’ in the API 570 BoK. B31.3 is a construction code for the manufacture and testing of new piping. It is subdivided into a large number of chapters and sections, several of which are applied to welding repair, pressure testing and other in-service activities. ASME B31.3 is the code referenced frequently in API 570 and so forms an important part of the API 570 BoK.
Introduction to API 510
Authors: Matthews Clifford
Published: July 2023

API 510 and its partner API 570 are the most common ICPs. Vessels come in many forms and sizes and API 510 provides general coverage of unfired vessels (not boilers or fired heat-exchangers). It can be used for not only refinery hydrocarbon and process vessels but (with interpretation) vessels from other process industries also.
API RP 571: Damage Mechanisms (API 510)
Authors: Matthews Clifford
Published: July 2023

API RP 571: Damage Mechanisms Affecting Fixed Equipment in the Refining Industry appears in all three ICP BoKs as follows
Tank Non-Destructive Examination (NDE)
Authors: Matthews Clifford
Published: July 2023

API exams like to ask questions about NDE. Monitoring the extent of NDE required and assessing the results is a large part of the API inspector’s role, even though the tests themselves are usually performed by the NDE examiner. Potential exam questions for API 653 consist of questions sourced from
API 510/570/653 ICP Examinations: What to Expect
Authors: Matthews Clifford
Published: July 2023

The API 510, 570 and 653 examinations have changed over the past few years and now consist of 170 multiple choice questions, comprising 110 closed-book questions and 60 open-book questions. Of these, 30 are classified as ‘pre-test questions’ and don’t count towards your final score.
Mental Fatigue Impairs Tackling Technique in Amateur Rugby Union Players
Authors: Davidow Demi , Smith Mitchell , Ross Tayla , Laura James Gwyneth , Paul Lara , Lambert Michael , Jones Ben , Hendricks Sharief
Published: July 2023

Purpose: To test the effects of mental fatigue (MF) on tackling technique on the dominant and nondominant shoulders in rugby union. Methods: Twenty male amateur rugby union players and a total of 953 tackles were analyzed. A randomized crossover counterbalanced design was used across a non-MF (control) and an MF condition. During each condition, each player performed 24 tackles, divided into 4 sets of 6 tackles (3 tackles on each shoulder). In the MF condition, players performed the Stroop Task between each set of tackles. A video recording of each tackle was used to evaluate each player’s technical proficiency. A score of 1 point was awarded if a specific technique was performed correctly, and 0 point was given if not. The total score, measured in arbitrary units (AU) out of 11, represents the player’s overall tackling proficiency. Results: Overall, players displayed a significantly lower technical proficiency score in the MF condition compared to control (set 2: control 7.30 [7.04–7.57] AU vs MF 6.91 [6.70–7.12] AU, P = .009, effect size (ES) = 0.30 small and set 3: control 7.34 [7.11–7.57] AU vs MF 6.88 [6.66–7.11] AU, P = .002, ES = 0.37 small). For the nondominant shoulder, players had a significantly lower technical proficiency score during the MF condition at set 2 (control 7.05 [6.68–7.41] AU vs MF 6.69 [6.42–6.96] AU, P = .047, ES = 0.29 small) and set 3 (control 7.14 [6.83–7.45] AU vs MF 6.61 [6.35–6.87] AU, P = .007, ES = 0.49 small). Conclusions: MF can diminish a player’s overall tackling proficiency, especially when tackling on the nondominant shoulder. The physiological mechanism for this finding may be impaired executive function and suboptimal functioning of neural signals and pathways, which result in less skillful coordination of movement. To further understand and explain MF-induced physiological changes in tackling, the feasibility of monitoring brain activity (such as electroencephalogram) and neuromuscular function (such as electromyogram) needs to be investigated. The findings from this study may also contribute to the development of more effective tackle training programs for injury prevention and performance.
Purpura fulminans in a hyposplenic patient arising from pneumococcal sinusitis
Authors: Tew Zi Yi , Johnson Daniel , Louis Gerard , Bhowmick Kaushik
Published: July 2023

We report a previously healthy woman in her 50s who presented with sepsis, rapidly progressive purpuric rash and disseminated intravascular coagulation. She was diagnosed with acute infective purpura fulminans due to invasive pneumococcal infection likely secondary to sinusitis. Our case report discusses our initial diagnostic uncertainty and approach in investigating and treating such a critically unwell patient.
Shear Bond Strength of Colored and Sandblasted Zirconia to Ceramic Veneers Fabricated by the Pressing and Layering Techniques: An In Vitro Study
Authors: Abbasi Mahsa , Ebadian Behnaz , Aminianpour Negin
Published: July 2023

Introduction. Porcelain-veneered zirconia (PVZ) restorations are increasingly used due to their optimal esthetics and high strength. However, chipping of porcelain limits the application of PVZ restorations. The aim of this study was to assess the shear bond strength (SBS) of colored and sandblasted zirconia to ceramic veneers fabricated by the pressing and layering techniques. Materials and Methods. Sixty cubic zirconia specimens (10 × 10 × 2 mm) were assigned to three groups according to their surface treatment: (I) control, (II) sandblasting with 50 μm alumina particles (S), and (III) coloring (C). Each group was subsequently divided into two subgroups according to the porcelain-veneering technique: (I) layering (L) and (II) pressing (P). The specimens underwent 10,000 thermal cycles between 5 and 55°C, and their biaxial SBS was measured in an electromechanical universal test machine (0.5 mm/min with 2.5 kN load cell). The failure mode was also assessed under a stereomicroscope. Three samples were randomly selected from each subgroup (n = 18) for examination of zirconia-phase transformation by X-ray diffraction (XRD). Two-way and one-way ANOVA followed by the post hoc Tukey test were used to analyze statistical differences among the groups and subgroups (α = 0.05). Results. The sandblasted zirconia with press porcelain (SP) subgroup showed the highest (24.40 ± 8.16 MPa) and the colored zirconia with press porcelain (CP) subgroup showed the lowest (13.76 ±3.62 MPa) SBS. All failures were cohesive. Rate of phase transformation in layered porcelain was significantly lower than that in pressed porcelain (P<0.01). Conclusion. The sandblasted group showed the highest and the colored group showed the lowest SBS; the layered group showed higher SBS than the pressed group.
A Target Damage Effectiveness Assessment Mathematical Calculation Method with Uncertain Information Based on an Adaptive Fuzzy Neural Network
Authors: Li Hanshan , Zhang Xiaoqian
Published: July 2023

Aiming to address the issue of assessing the effectiveness of target damage in air defense interception under projectile and target intersection, this paper proposes a novel target damage effectiveness assessment mathematical calculation method using an adaptive fuzzy neural network. The design and calculation methods introduce the target cabin’s damage weight factor, the dispersion error and coverage density and fire density of warhead fragment, and the ratio of the number of warhead fragments to the cross‐sectional area of the target as the primary damage factors, and we establish a new model for calculating the target damage efficiency using Takagi‐Sugeno adaptive fuzzy neural network with the multiple damage factors. In the designed model, we take the characteristic parameters of warhead fragments formed by the projectile explosion as the sample data and learn the mapping relationship between damage factors and damage effect expressed by the system of fuzzy rule. Combined with the vulnerability weight and damage factors of the target, the fuzzy rule system is applied to predict and calculate the damage probability and damage effectiveness. In addition, we use shot‐line technology to set up the intersection criterion between warhead fragments and target, analyze the coordinate relationship of the projectile explosion relative to the target based on the ground coordinate system, and derive the distribution density function of warhead fragment and research a calculation model for target damage probability with multiple vulnerable cabins. Finally, we use the established model to train, test, and calculate the data from the actual projectile and target intersection damage test and present the comparison results to other damage calculation methods. By calculation and comparative analysis, the results show the smaller the distance between projectile and target, as well as the smaller the average intersection angle, and the larger the weight coefficient of the warhead fragment covering the target cabin, the total target damage probability increases obviously. In the two experimental calculations, the target cabin with the largest weight coefficient was considered, and compared with the existing literature, the damage probability of the proposed calculation method was increased by 9.13% and 10.93%, respectively, and it is clear that the proposed target damage assessment method can effectively reflect the real target damage effectiveness in the state of projectile and target intersection.
MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads
Authors: Uliano-Silva Marcela , Ferreira João Gabriel R. N. , Krasheninnikova Ksenia ,   Darwin Tree of Life Consortium, Blaxter Mark , Mieszkowska Nova , Hall Neil , Holland Peter , Durbin Richard , Richards Thomas , Kersey Paul , Hollingsworth Peter , Wilson Willie , Twyford Alex , Gaya Ester , Lawniczak Mara , Lewis Owen , Broad Gavin , Martin Fergal , Hart Michelle , Barnes Ian , Formenti Giulio , Abueg Linelle , Torrance James , Myers Eugene W. , Durbin Richard , Blaxter Mark , McCarthy Shane A.
Published: July 2023

Background

 PacBio high fidelity (HiFi) sequencing reads are both long (15–20 kb) and highly accurate (> Q20). Because of these properties, they have revolutionised genome assembly leading to more accurate and contiguous genomes. In eukaryotes the mitochondrial genome is sequenced alongside the nuclear genome often at very high coverage. A dedicated tool for mitochondrial genome assembly using HiFi reads is still missing.

Results

 MitoHiFi was developed within the Darwin Tree of Life Project to assemble mitochondrial genomes from the HiFi reads generated for target species. The input for MitoHiFi is either the raw reads or the assembled contigs, and the tool outputs a mitochondrial genome sequence fasta file along with annotation of protein and RNA genes. Variants arising from heteroplasmy are assembled independently, and nuclear insertions of mitochondrial sequences are identified and not used in organellar genome assembly. MitoHiFi has been used to assemble 374 mitochondrial genomes (368 Metazoa and 6 Fungi species) for the Darwin Tree of Life Project, the Vertebrate Genomes Project and the Aquatic Symbiosis Genome Project. Inspection of 60 mitochondrial genomes assembled with MitoHiFi for species that already have reference sequences in public databases showed the widespread presence of previously unreported repeats.

Conclusions

 MitoHiFi is able to assemble mitochondrial genomes from a wide phylogenetic range of taxa from Pacbio HiFi data. MitoHiFi is written in python and is freely available on GitHub (https://github.com/marcelauliano/MitoHiFi). MitoHiFi is available with its dependencies as a Docker container on GitHub (ghcr.io/marcelauliano/mitohifi:master).
RegEMR: a natural language processing system to automatically identify premature ovarian decline from Chinese electronic medical records
Authors: Cai Jie , Chen Shenglin , Guo Siyun , Wang Suidong , Li Lintong , Liu Xiaotong , Zheng Keming , Liu Yudong , Chen Shiling
Published: July 2023

Background

The ovarian reserve is a reservoir for reproductive potential. In clinical practice, early detection and treatment of premature ovarian decline characterized by abnormal ovarian reserve tests is regarded as a critical measure to prevent infertility. However, the relevant data are typically stored in an unstructured format in a hospital’s electronic medical record (EMR) system, and their retrieval requires tedious manual abstraction by domain experts. Computational tools are therefore needed to reduce the workload.

Methods

We presented RegEMR, an artificial intelligence tool composed of a rule-based natural language processing (NLP) extractor and a knowledge-based disease scoring model, to automatize the screening procedure of premature ovarian decline using Chinese reproductive EMRs. We used regular expressions (REs) as a text mining method and explored whether REs automatically synthesized by the genetic programming-based online platform RegexGenerator +  + could be as effective as manually formulated REs. We also investigated how the representativeness of the learning corpus affected the performance of machine-generated REs. Additionally, we translated the clinical diagnostic criteria into a programmable disease diagnostic model for disease scoring and risk stratification. Four hundred outpatient medical records were collected from a Chinese fertility center. Manual review served as the gold standard, and fivefold cross-validation was used for evaluation.

Results

The overall F-score of manually built REs was 0.9444 (95% CI 0.9373 to 0.9515), with no significant difference (paired t test p > 0.05) compared with machine-generated REs that could be affected by training set sizes and annotation portions. The extractor performed effectively in automatically tracing the dynamic changes in hormone levels (F-score 0.9518–0.9884) and ultrasonographic measures (F-score 0.9472–0.9822). Applying the extracted information to the proposed diagnostic model, the program obtained an accuracy of 0.98 and a sensitivity of 0.93 in risk screening. For each specific disease, the automatic diagnosis in 76% of patients was consistent with that of the clinical diagnosis, and the kappa coefficient was 0.63.

Conclusion

A Chinese NLP system named RegEMR was developed to automatically identify high risk of early ovarian aging and diagnose related diseases from Chinese reproductive EMRs. We hope that this system can aid EMR-based data collection and clinical decision support in fertility centers.
Prevalence and modifiable risk factors for dementia in persons with intellectual disabilities
Authors: Takenoshita Shintaro , Terada Seishi , Inoue Tomokazu , Kurozumi Taku , Yamada Norihito , Kuwano Ryozo , Suemitsu Shigeru
Published: July 2023

Background

People with intellectual disability (ID) without Down syndrome (DS) are presumed to be at higher risk of developing dementia due to their lower baseline cognitive reserve. We aimed to determine the prevalence of dementia in people with ID without DS and to identify risk factors of dementia.

Methods

This was a cross-sectional survey and multicenter study in Japan. Adults with ID without DS residing in the facilities were included. Caregivers of all participants were interviewed by medical specialists, and participants suspected of having cognitive decline were examined directly. ICD-10 criteria for dementia, DC-LD criteria for dementia, and DSM-5 criteria for neurocognitive disorders were used to diagnose dementia. The severity of ID, educational history, and comorbidities were compared by dividing the groups into those with and without dementia.

Results

A total of 1831 participants were included; 118/1831 (6.44%) were diagnosed with dementia. The prevalence of dementia for each age group was 8.8%, 60–64 years; 9.0%, 65–69 years; 19.6%, 70–74 years; and 19.4%, 75–79 years. Age, severity of ID, duration of education, hypertension, depression, stroke, and traumatic brain injury were significantly associated with the presence of dementia.

Conclusions

Although the prevalence of dementia in people with ID without DS was found to be higher at a younger age than in the general population, the results of this study suggested that adequate education, prevention of head trauma and stroke, and treatments of hypertension and depression may reduce the risk of dementia. These may be potentially important modifiable risk factors for the prevention of dementia in these people.
Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report
Authors: Sánchez-Boluarte Sofía S. , Aguirre-Quispe Wilfor , Herrera Aramburú Manuel , Tatum William O. , De La Cruz Ramírez Walter
Published: July 2023

Background

Focal cortical dysplasia (FCD) is a common cause of drug-resistant epilepsy. Electroencephalography (EEG) biomarkers that predict good postoperative outcomes are essential for identifying patients with focal epilepsies.

Case presentation

We report the case of a 21-year-old female with seizure onset at the age of 9, characterized by left-hand dystonic posturing and impaired awareness, which evolved to bilateral tonic-clonic seizures, evaluated in a neurological referral center in Lima, Peru. During 6-h video-EEG, interictal EEG revealing focal brief potentially ictal rhythmic discharges (BIRDs) over the right frontal central region, lasting less than 10 s. The ictal features were characterized by low-voltage fast activity over the same area. Brain magnetic resonance imaging (MRI) demonstrated a focal lesion of focal cortical dysplasia type II in the right frontal lobe. The patient underwent a lesionectomy guided by electrocorticography, which showed continuous polyspikes. BIRDs showing a brief burst of spikes lasting longer than 0.5 s, were also identified on intraoperative electrocorticography (ECoG) and helped define the extent of resection. The patient obtained an Engel Outcome Class IA at 6 years of follow-up.

Conclusions

The atypical BIRDs on ECoG can be used as a prognostic biomarker for prolonged seizure-freedom outcome in patients with epilepsy. Additional reports are needed in developing countries with and without brain MRI lesions to advance outpatient presurgical evaluations despite limited resources.