bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Professionals of Prevention in Italy: The Value of Expertise During COVID-19 Pandemic
Authors: Wachocka Malgorzata , Pattavina Fabio , Palluzzi Vincenzo , Cerabona Vito , Laurenti Patrizia
Published: December 2020

There are 22 different degree courses related to the Healthcare Professions in the Italian university system, which are divided into four areas. “Healthcare Professions of Prevention” is the fourth area and it is fundamental for the National Health Service. In particular, in this pandemic emergency situation, the contribution of the Prevention Technicians in the Environment and Workplaces (PTEW) is essential in the field and workplace management. The “Core Competence” of the PTEW is to carry out, with professional autonomy, prevention, verification, and control activities in the field of hygiene and safety of living and working environments. In the hospitals, the indications provided by national and/or regional authorities are implemented through procedures on good hygiene practices developed by PTEW (e.g., hand hygiene, “respiratory tract hygiene,” environmental hygiene, social distancing, and use of Personal Protective Equipment). One of the activities is the health surveillance on the field by population monitoring. The protocols foreseen for the “in-flow of workers” involve a wider control between social life and work. The PTEW will use a Check List divided into 3 macro phases: Entry, Activity Context, and Exit, defining each behavior of the work phases with a constant presence of verification of the procedures. The PTEW will be a Leader on the topics of education, training, and persuasion, considering a New Principle that “transforms the worker as active part in the application and diffusion of the safety measures”.
Radiographic and Venographic Appearance of Healthy and Laminitic Feet in Amiata Donkeys
Authors: Nocera Irene , Aliboni Benedetta , Ben David Liri , Gracia-Calvo Luis Alfonso , Sgorbini Micaela , Citi Simonetta
Published: December 2020

Introduction:Laminitis is a debilitating disorder resulting in irreversible anatomical changes in the feet of equids. Assessing specific anatomical features through radiography and venography provides diagnostic and prognostic information. The reference ranges are well-established in horses, but not in donkeys. It is also uncertain as to whether these ranges can be applied to every donkey breed. The present study characterizes the radiological and venographic hoof anatomy of healthy feet of Amiata donkeys and defines the changes associated with severe and mild laminitis.

Materials and Methods:A total of 16 forefeet were evaluated in 8 Amiata jennies. The animals underwent musculoskeletal examination, Obel grading assessment and radiological evaluation. Based on clinical examination and radiographic findings, the forefeet were grouped as healthy, mild or severe laminitic feet, thus the digital venograms were performed according to the group definition.

Results:Radiology revealed 7/16 healthy, 4/16 mild laminitic, and 5/16 severe laminitic forefeet. Statistical analysis showed differences between the healthy and laminitic forefeet for the dorsal angle (p< 0.0001) and angle of solar aspect (p< 0.0001) of the distal phalanx, for deviation between dorsal aspect of distal phalanx and the hoof wall (p< 0.0001) and phalangeal rotation angle (p= 0.0032). Venography was abnormal in mild and severe laminitic forefeet. In particular, the vascularization was reduced or absent at the lamellar-circumflex junction dorsally, at the sub-lamellar vascular bed and at the circumflex veins. Coronary plexus vascularization was absent in severe laminitic forefeet.

Discussion and Conclusions:This study provides the radiological parameters for the assessment of healthy and laminitic forefeet of Amiata donkeys. The mild laminitic foot venogram showed decreased vascularization mainly on lamellar-circumflex junction and sub-lamellar vascular bed, in latero-medial views. The severe laminitic foot showed very poor or absent vascularization in multiple areas. The technique is easily applicable and provides diagnostic support in laminitis.
Refinements to Animal Models for Biomedical Research
Authors: Musk Gabrielle C.
Published: December 2020

This collection includes the manuscripts published in the Special Issue of Animals: Refinements to Animal Models for Biomedical Research [...]
Drilling Capability of Orthodontic Miniscrews: In Vitro Study
Authors: Marchi Alessandra , Camporesi Matteo , Festa Maurizio , Salvatierra Luis , Izadi Sara , Farronato Giampietro
Published: December 2020

The aims of this study were to assess the values and mechanical properties of insertion torque (IT) of steel miniscrews inserted in artificial bone blocks (Sawbones, Pacific Research Laboratories, Vashon, WA, USA) with different bone densities and to detect any scratches on the surface of the miniscrews after insertion. Forty self-drilling miniscrews (Leone S.p.A. ø 1.75 mm, L 8 mm) have been inserted into bone blocks that mimic different stability conditions (density: 20 PCF—pounds per cubic foot, 40 PCF, and 30 + 50 PCF with 2 mm and 4 mm of cortical bone). Before insertion and after removal, all miniscrews were inspected with a stereomicroscope 5x and a SEM to detect potential microscopic cracks. Using an electronic surgical motor (W&H Dentalwerk Bürmoos GmbH, Werner Bader Str. 1, 5111 Bürmoos, Austria), the maximum insertion torque value was registered. Stereomicroscope and SEM examination did not indicate any morphological and surface structural changes to the miniscrews, irrespective of the bone density they were inserted into. The findings showed that IT increased significantly with increasing bone density. In each artificial bone block, morphostructural analysis demonstrated the adequate mechanical properties of the self-drilling miniscrews. IT measurements indicated torque values between 6 and 10 Ncm for blocks with a density of 30 + 50 PCF, whereas the suggested values are between 5 and 10 Ncm.
Psychological Effects of the COVID-19 Pandemic on Hungarian Adults
Authors: Szabó Csanád , Pukánszky Judit , Kemény Lajos
Published: December 2020

We aimed to explore psychological effects of the coronavirus pandemic on Hungarian adults in the time of the national quarantine situation in May 2020.We conducted a cross-sectional observational study with the use of an anonymous online questionnaire that consisted of 65 items. The following measuring instruments were used: Perceived Stress Scale (PSS-10); The General Anxiety Disorder Assessment (GAD)-2; The Patient Health Questionnaire (PHQ)-2; European Quality of Life Visual Analogue Scale (EQ-VAS); Self-administered inventory of complaints (Hungarian questionnaire); Shortened (Hungarian) version of the Ways of Coping Questionnaire; 2 open-ended questions to examine the participants’ mood and ways of coping during the pandemic. The data of 431 participants were analyzed, their average age was 47.53 ± 11.66 years, and the percentage of females was 90%. The mean of participants’ scores were the following: 19.34 ± 7.97 for perceived stress, 73.05 ± 21.73 for health status, and 8.68 ± 4.65 for neurotic complaints. Thirty-four and one-tenth percent of participants were depressed, 36.2% were anxious, and they tended to use problem-focused coping strategies more frequently than emotion-focused ones. We found significant correlations between all of the seven examined psychological variables. Our results highlight the importance of stress management in the psychological support of healthy adults in quarantine situation caused by the coronavirus pandemic.
Secure and Sustainable Sourcing of Plant Tissues for the Exhaustive Exploration of Their Chemodiversity
Authors: Joseph Rhodin C. , Silva da Fonseca Diniz Matheus , Magno do Nascimento Viviane , Barbosa Muribeca Abraão de Jesus , Costa Santiago Johan Carlos , da Cunha Borges Luziane , da Costa Sá Paulo Roberto , Portal Gomes Paulo Wender , da Silva Cardoso Júlio César , Rocha de Castro Marcela Natalia , Fiusa Thais , Rogez Hervé , Darnet Sylvain , Pinheiro Arruda Mara Silvia , Nascimento da Silva Milton , Cardoso Arruda Alberto , Boutin Jean A. , Silva Consuelo Yumiko Yoshioka e , Lautié Emmanuelle
Published: December 2020

The main challenge of plant chemical diversity exploration is how to develop tools to study exhaustively plant tissues. Their sustainable sourcing is a limitation as bioguided strategies and dereplication need quite large amounts of plant material. We examine if alternative solutions could overcome these difficulties by obtaining a secure, sustainable, and scalable source of tissues able to biosynthesize an array of metabolites. As this approach would be as independent of the botanical origin as possible, we chose eight plant species from different families. We applied a four steps culture establishment procedure, monitoring targeted compounds through mass spectrometry-based analytical methods. We also characterized the capacities of leaf explants in culture to produce diverse secondary metabolites. In vitro cultures were successfully established for six species with leaf explants still producing a diversity of compounds after the culture establishment procedure. Furthermore, explants from leaves of axenic plantlets were also analyzed. The detection of marker compounds was confirmed after six days in culture for all tested species. Our results show that the first stage of this approach aiming at easing exploration of plant chemodiversity was completed, and leaf tissues could offer an interesting alternative providing a constant source of natural compounds.
Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927
Authors: Lee Alex J. , Cadelis Melissa M. , Kim Sang H. , Swift Simon , Copp Brent R. , Villas-Boas Silas G.
Published: December 2020

We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A—a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV–Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH.
Improvement of Naturally Derived Food Colorant Performance with Efficient Pyranoanthocyanin Formation from Sambucus nigra Anthocyanins Using Caffeic Acid and Heat
Authors: Straathof Nicole , Giusti M. Monica
Published: December 2020

Consumers and regulations encourage the use of naturally derived food colorants. Anthocyanins (ACN), plant pigments, are unstable in foods. In aged red wines, ACN with a free hydroxyl group at C-5 condenses to form pyranoanthocyanins (PACN), which are more stable but form inefficiently. This study attempted to produce PACN efficiently using high cofactor concentration and heat. Elderberry anthocyanins were semi-purified and caffeic acid (CA) was dissolved in 15% ethanol and diluted with a buffer to achieve ACN:CA molar ratios of 1:50, 1:100, 1:150, and 1:200, then incubated at 65 °C for 5 days. The effect of temperature was tested using ACN samples incubated with or without CA at 25 °C, 50 °C, and 75 °C for 7 days. Compositional changes were monitored using uHPLC-PDA-MS/MS. Higher CA levels seemed to protect pigment integrity, with ACN:CA 1:150 ratio showing the highest tinctorial strength after 48 h. PACN content growth was fastest between 24 and 48 h for all ACN:CA ratios and after 120 h, all ACN had degraded or converted to PACN. PACN formed faster at higher temperatures, reaching ~90% PACN in 24 h and ~100% PACN in 48 h at 75 °C. These results suggest that PACN can form efficiently from elderberry ACN and CA if heated to produce more stable pigments.
Synthesis and Influence of 3-Amino Benzoxaboroles Structure on Their Activity against Candida albicans
Authors: Wieczorek Dorota , Kaczorowska Ewa , Wiśniewska Marta , Madura Izabela D. , Leśniak Magdalena , Lipok Jacek , Adamczyk-Woźniak Agnieszka
Published: December 2020

Benzoxaboroles emerged recently as molecules of high medicinal potential with Kerydin® (Tavaborole) and Eucrisa® (Crisaborole) currently in clinical practice as antifungal and anti-inflammatory drugs, respectively. Over a dozen of 3-amino benzoxaboroles, including Tavaborole’s derivatives, have been synthetized and characterized in terms of their activity against Candida albicans as a model pathogenic fungus. The studied compounds broaden considerably the structural diversity of reported benzoxaboroles, enabling determination of the influence of the introduction of a heterocyclic amine, a fluorine substituent as well as the formyl group on antifungal activity of those compounds. The determined zones of the growth inhibition of examined microorganism indicate high diffusion of majority of the studied compounds within the applied media as well as their reasonable activity. The Minimum Inhibitory Concentration (MIC) values show that the introduction of an amine substituent in position “3” of the benzoxaborole heterocyclic ring results in a considerable drop in activity in comparison with Tavaborole (AN2690) as well as unsubstituted benzoxaborole (AN2679). In all studied cases the presence of a fluorine substituent at position para to the boron atom results in lower MIC values (higher activity). Interestingly, introduction of a fluorine substituent in the more distant piperazine phenyl ring does not influence MIC values. As determined by X-ray studies, introduction of a formyl group in proximity of the boron atom results in a considerable change of the boronic group geometry. The presence of a formyl group next to the benzoxaborole unit is also detrimental for activity against Candida albicans.
Halogen-Induced Controllable Cyclizations as Diverse Heterocycle Synthetic Strategy
Authors: China Hideyasu , Kumar Ravi , Kikushima Kotaro , Dohi Toshifumi
Published: December 2020

In organic synthesis, due to their high electrophilicity and leaving group properties, halogens play pivotal roles in the activation and structural derivations of organic compounds. Recently, cyclizations induced by halogen groups that allow the production of diverse targets and the structural reorganization of organic molecules have attracted significant attention from synthetic chemists. Electrophilic halogen atoms activate unsaturated and saturated hydrocarbon moieties by generating halonium intermediates, followed by the attack of carbon-containing, nitrogen-containing, oxygen-containing, and sulfur-containing nucleophiles to give highly functionalized carbocycles and heterocycles. New transformations of halogenated organic molecules that can control the formation and stereoselectivity of the products, according to the difference in the size and number of halogen atoms, have recently been discovered. These unique cyclizations may possibly be used as efficient synthetic strategies with future advances. In this review, innovative reactions controlled by halogen groups are discussed as a new concept in the field of organic synthesis.
Present Status and Future Trends of Natural-Derived Compounds Targeting T Helper (Th) 17 and Microsomal Prostaglandin E Synthase-1 (mPGES-1) as Alternative Therapies for Autoimmune and Inflammatory-Based Diseases
Authors: Saviano Anella , Raucci Federica , Casillo Gian Marco , Indolfi Chiara , Pernice Alessia , Foreste Carmen , Iqbal Asif Jilani , Mascolo Nicola , Maione Francesco
Published: December 2020

Several natural-based compounds and products are reported to possess anti-inflammatory and immunomodulatory activity both in vitro and in vivo. The primary target for these activities is the inhibition of eicosanoid-generating enzymes, including phospholipase A2, cyclooxygenases (COXs), and lipoxygenases, leading to reduced prostanoids and leukotrienes. Other mechanisms include modulation of protein kinases and activation of transcriptases. However, only a limited number of studies and reviews highlight the potential modulation of the coupling enzymatic pathway COX-2/mPGES-1 and Th17/Treg circulating cells. Here, we provide a brief overview of natural products/compounds, currently included in the Italian list of botanicals and the BELFRIT, in different fields of interest such as inflammation and immunity. In this context, we focus our opinion on novel therapeutic targets such as COX-2/mPGES-1 coupling enzymes and Th17/Treg circulating repertoire. This paper is dedicated to the scientific career of Professor Nicola Mascolo for his profound dedication to the study of natural compounds.
Microextraction Techniques with Deep Eutectic Solvents
Authors: Plastiras Orfeas-Evangelos , Andreasidou Eirini , Samanidou Victoria
Published: December 2020

In this review, the ever-increasing use of deep eutectic solvents (DES) in microextraction techniques will be discussed, focusing on the reasons needed to replace conventional extraction techniques with greener approaches that follow the principles of green analytical chemistry. The properties of DES will be discussed, pinpointing their exceptional performance and analytical parameters, justifying their current extensive scientific interest. Finally, a variety of applications for commonly used microextraction techniques will be reported.
Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging
Authors: Munch Maxime , Rotstein Benjamin H. , Ulrich Gilles
Published: December 2020

Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures. However, this imaging modality still suffers from a low depth of penetration, thus limiting its use to shallow tissues or endoscopy-based procedures. In contrast, positron emission tomography (PET) presents a high depth of penetration and the resulting signal is less attenuated, allowing for imaging in-depth tissues. Thus, association of these imaging techniques has the potential to push back the limits of each single modality. Recently, several research groups have been involved in the development of radiolabeled fluorophores with the aim of affording dual-mode PET/OPI probes used in preclinical imaging studies of diverse pathological conditions such as cancer, Alzheimer’s disease, or cardiovascular diseases. Among all the available PET-active radionuclides, 18F stands out as the most widely used for clinical imaging thanks to its advantageous characteristics (t1/2 = 109.77 min; 97% β+ emitter). This review focuses on the recent efforts in the synthesis and radiofluorination of fluorescent scaffolds such as 4,4-difluoro-4-bora-diazaindacenes (BODIPYs), cyanines, and xanthene derivatives and their use in preclinical imaging studies using both PET and OPI technologies.
Mapping the Chiroptical Properties of Local Domains in Thin Films of Chiral Silicon Phthalocyanines by CD Imaging
Authors: Răsădean Dora-M. , Gianga Tiberiu-M. , Jávorfi Tamás , Hussain Rohanah , Siligardi Giuliano , Pantoș G. Dan
Published: December 2020

The first example of uniformly chiral thin films of silicon phthalocyanines (SiPcs) are reported. The local domains of the films are mapped using circular dichroism (CD) imaging (CDi) technique available at the Diamond B23 beamline. The CDi allowed us to increase the spatial resolution up to 525× when compared with benchtop spectrometers. The results indicate formation on-surface of chiral and stable supramolecular assemblies with homogenous distribution. Chemical functionalization and solvent choice for deposition allow controllable chiroptical properties to be obtained. The method and technique reported in this work could be applied to prepare and characterize a wide variety of chiral thin films.
Spectral Unmixing for Mapping a Hydrothermal Field in a Volcanic Environment Applied on ASTER, Landsat-8/OLI, and Sentinel-2 MSI Satellite Multispectral Data: The Nisyros (Greece) Case Study
Authors: Tompolidi Athanasia-Maria , Sykioti Olga , Koutroumbas Konstantinos , Parcharidis Issaak
Published: December 2020

The aim of this study was to propose a methodology that provides a detailed description of the argillic zone of a hydrothermal field, based on satellite multispectral data. More specifically, we developed a method based on spectral unmixing where hydroxyl-bearing alteration is represented by a single endmember (representing clays) and the three (nearly) non-altered primary volcanic lithologies, namely, two types of lava flows (basic and acidic compositions) and the loose materials (alluvial/beach deposits, scree, pyroclastic deposits, etc.), are represented by three endmembers. We also used one endmember representing elemental sulfur that is present in fumarolic vents hosted by active hydrothermal craters. The methodology was applied in the south part of Lakki plain inside the Nisyros volcano caldera (Greece), using Sentinel-2, Landsat-8/OLI, and ASTER satellite multispectral datasets. Specifically, it was applied separately to each one of the three datasets. The spectral unmixing results, combined with the relative geological map, provide quantitative estimations of the primary volcanic and loose material areas affected by alteration. In addition, pixels with high abundance values of hydroxyl-bearing alteration corresponded to mapped areas with strong hydrothermal alteration. The developed methodology is superior to conventional approaches (e.g., alteration spectral index) in terms of its ability to describe the overall pattern of the hydrothermal field. The most accurate results were taken when applied to ASTER or Sentinel-2 MSI data.
Experimental and Numerical Analysis of Multi-Hole Orifice Flow Meter: Investigation of the Relationship between Pressure Drop and Mass Flow Rate
Authors: Tomaszewski Adam , Przybylinski Tomasz , Lackowski Marcin
Published: December 2020

The paper presents the results of the experimental and numerical analysis of a six-hole orifice flow meter. The experiments were performed on humid air in a 100 mm diameter duct. The aim of this research was to investigate the mass flow and pressure drop dependency in an orifice of a predetermined shape and to compare the results obtained with computational formulas recommended in the ISO 5167-2 standard for a single-hole orifice flow meter. The experiments and calculations were performed on several multi-hole orifice geometries with different contraction coefficient in a wide range of Reynolds numbers. The pressure was probed immediately upstream and downstream of the orifice. The flow coefficient determined for the six-hole orifice flow meter investigated was compared with the flow coefficient of conventional single-hole orifice with the same contraction coefficient. The results from computational formulas for single-hole orifice from ISO 5167 are also included in the paper. During some experiments, an obstacle has been introduced in the duct at variable distance upstream from the orifice. The effect of the thus generated velocity field disturbance on the measured pressure drop was then investigated. Numerical simulation of the flow with the presence of the obstacle was also performed and compared with experimental data.
Design and Social Factors Affecting the Formation of Social Capital in Chinese Community Garden
Authors: Ding Xiaoying , Zhang Yukun , Zheng Jie , Yue Xiaopeng
Published: December 2020

In recent years, community gardens are becoming more and more popular in China. However, the role of these community gardens varies significantly: some community gardens serve as an effective means of promoting social capital, while others cause social contradictions and public doubts due to the lack of professional design and management. Therefore, this paper aims to learn and better understand what factors affect the formation of social capital in Chinese community gardens. It screened eleven design factors and seven social factors and made social capital scale through literature review and expert workshop. On this basis, this study selected 35 community gardens in China as sample spaces, and collected 1257 questionnaires about the perception for social capital of gardeners through survey. In the statistical analysis phase, factor analysis and regression analysis were applied to analyze the role and the relative importance of different factors and social capital. Results show that the integration with green infrastructure, accessibility, size, visual openness, planting form, proportion of unproductive landscape, agricultural infrastructure, and smart infrastructure have significant impacts on social capital level. Meanwhile, the types of stakeholders, management rules, supervision system, self-management team, and operational activities have similar impacts on social capital level. This study recommends that planners and designers should adjust the above related factors in community garden design, and local government is urged to integrate community gardens into urban plans and public policies.
A Study on Sustainable Usage Intention of Blockchain in the Big Data Era: Logistics and Supply Chain Management Companies
Authors: Park Kwang O.
Published: December 2020

The adoption of blockchain technology (BT) is becoming increasingly important to the logistics industry. It is expected to make the entire supply chain process more efficient and competitive by providing visibility, reliability, and economic viability. This study aims to explore factors influencing the adoption of blockchain in the logistics industry and examine the effects of the reciprocal causal relationship between the identified factors. Empirical research aimed at understanding the functional characteristics of BT and bolstering its application is considerably lacking. This study, therefore, aims to examine the concepts and the types of BT based on a literature review related to blockchain. Factors affecting blockchain adoption are identified using a model, which was developed using the unified theory of acceptance and use of technology (UTAUT) and the technology-organization-environment (TOE) frameworks as well as a literature review. The results provide fundamental insights into the adoption of BT in the logistics industry by increasing the understanding of associated factors and underscoring the functional characteristics of this emerging technology.
Construction Method and Performance Analysis of Chaotic S-Box Based on a Memorable Simulated Annealing Algorithm
Authors: Wang Juan , Zhu Yangqing , Zhou Chao , Qi Zhiming
Published: December 2020

The substitution box (S-box) is the only nonlinear components in the symmetric block cipher. Its performance directly determines the security strength of the block cipher. With the dynamic characteristics degradation and the local periodic phenomenon of digital chaos, and the security problems caused by them becoming more and more prominent, how to efficiently generate an S-box with security guarantee based on chaos has gradually attracted the attention of cryptographers. In this paper, a chaotic S-box construction method is proposed based on a memorable simulated annealing algorithm (MSAA). The chaotic S-box set is produced by using the nonlinearity and randomness of the dynamic iteration of digital cascaded chaotic mapping. The composite objective function is constructed based on the analysis of the performance indexes of S-box. The MSAA is used to efficiently optimize the S-box set. The matrix segmentation and scrambling operations are carried out on the optimized S-box. The cryptographic performance of chaotic S-box is tested and analyzed, and compared with the mainstream chaotic S-box of the same kind. The results show that the S-box constructed in this paper can not only stably and efficiently generate chaotic S-box with better performance, but also make an effective exploration of the construction of chaotic S-boxes based on intelligent algorithms.
KARAKTERISTIK INDIVIDU TERHADAP PERILAKU PEMERIKSAAN KESEHATAN TERDUGA TBC KE FASILITAS PELAYANAN KESEHATAN DI JAWA BARAT
Authors: Rahim Fitri Kurnia , Diniah Bibit Nasrokhatun , Wahyuniar Lely , Susianto Susianto , Puspanegara Aditiya , Hamdan Hamdan , Heriana Cecep
Published: December 2020

Indonesia memiliki kasus terbanyak ke-2 didunia. Sebanyak 32% kasus TBC tercatat sebagai un-reach atau detected but un-notified. Berdasarkan kegiatan pemberdayaan investigasi kontak masih ada sekitar 54% terduga TBC yang tidak melakukan pemeriksaan TBC di fasilitas layanan kesehatan (fasyankes) setelah dirujuk. Salah satu faktor yang dapat mempengaruhi perilaku pemeriksaan ke fasyankes adalah karakteristik individu terduga TBC. Penelitian ini bertujuan untuk mengetahui faktor dominan karakteristik individu yang mempengaruhi perilaku pemeriksaan ke fasyankes pada terduga TBC.

Penelitian ini menggunakan penelitian observasional analitik dengan metode kuantitatif dengan pendekatan cross sectional. Populasi penelitian ini sebanyak 426 responden. Sampel dalam penelitian ini bersifat probability sampling. Dengan teknik pengambilan sampel proportional random sampling. Pengumpulan data dengan wawancara menggunakan kuesioner online dengan google form Analisis yang digunakan adalah analisis chi-square dan multiple logistik berganda dengan nilai siginifikansi 95 %.

Hasil penelitian menunjukan terdapat 56,6 % terduga TBC yang belum melakukan pemeriksaan kesehatan di fasilitas kesehatan (fasyankes). Sebagian besar terduga yang tidak melakukan pemeriksaan yaitu memiliki latar belakang pendidikan SMP (30,3 %) dan tidak bekerja (47,7%). Faktor dominan yang mempengaruhi perilaku pemeriksaan TBC ke fasyankes adalah pendidikan (OR: 1,981; 95 % CI: 1,181-3,325; p 0,010), pekerjaan (OR: 1,738; 95 % CI: 1,1140-2,681; p 0,010), dan suku (OR: 0,382; 95 % CI: 0,159-0,916; p 0,031).

Faktor dominan yang mempengaruhi perilaku pemeriksaan pada terduga TBC adalah pendidikan, pekerjaan dan suku. Oleh karena itu, dalam program penemuan kasus perlu difokuskan pada masyarakat yang berlatar belakang pendidikan rendah, masyarakat yang tidak bekerja dan masyarakat yang berasal dari suku jawa.
Augmented Reality sebagai Media Edukasi Sejarah Bangunan Peninggalan Kesultanan Utsmaniyah menggunakan Metode Marker Based Tracking dan Algoritma Fast Corner Detection
Authors: Fayiz Muhammad , Hilmy Naufal , Darusalam Ucuk , Rubhasy Albaar
Published: December 2020

At this time, information and communication technology is growing rapidly. One example of technological developments is Augmented Reality (AR). Augmented Reality in theory is to present virtual effects in the real world. This AR technology has been applied in several fields. One of them is in the field of education. In this study, an AR application was made as an educational medium for the history of the heritage buildings of the Ottoman Empire, especially for Madrasah students in the subject of Islamic Cultural History (SKI). This research will discuss the history of heritage buildings of the Ottoman Empire such as; Hagia Sophia Monument, Yeni Valide Mosque, and Blue Mosque. The Ottoman Empire was one of the world's Islamic empires that played a major role in the spread of Islamic teachings. This AR application uses the Marker Based Tracking method and the Fast Corner Detection algorithm. The tools used are Android Studio, Unity 3D, Sketchup, Figma, and Vuforia. The results of this study resulted in the application having succeeded in displaying a 3D Object from the Ottoman Sultanate heritage building, along with a description next to the 3D Object. In addition, this Monument AR application also works well on the Android operating system.Keywords:Augmented Reality, Marker Based Tracking, Fast Corner Detection, 3D Object, Android.
Négytagú síkbeli mechanizmus tervezése és helyzetanalízise
Authors: Pál István , Burmeister Dániel
Published: December 2020

Jelen cikk egy négytagú síkbeli RRRP mechanizmus analitikus szintézisével és helyzetanalízisével foglalkozik. A vizsgálat tárgyát képező mechanizmus két kívánt helyzetéhez tartozó szintézise során vektorhurkok kerülnek felírásra, melyek skaláregyenletei egy nemlineáris egyenletrendszert alkotnak. A nemlineáris egyenletrendszer ismeretlenjei közül vannak szabadon választhatók, míg a többit numerikus eljárással határozzuk meg. A szabadon választott és ismeretlen változók megoldásai adják a mechanizmus tagjainak fő méreteit. A mechanizmus helyzetanalízise során szintén vektorhurkok skaláregyenletei szolgáltatnak nemlineáris egyenletrendszert, melyek segítségével meghatározhatók a mechanizmus másodlagos koordinátái az elsődleges koordináta függvényében.
ANALISIS HUKUM PIDANA DENDA PELANGGARAN LALU LINTAS DI KOTA BENGKULU (DITINJAU DARI UNDANG-UNDANG NOMOR 22 TAHUN 2009 TENTANG LALU LINTAS DAN ANGKUTAN JALAN)
Authors: Diansyah Apen
Published: December 2020

ABSTRAKPenelitian ini ditujukan untuk mengetahui penerapan denda terhadap pelanggar berlalu lintas di kota Bengkulu ditinjau dari Undang-undang Nomor 22 Tahun 2009, serta untuk mengetahui faktor penghambat dalam penerapan pidana denda terhadap pelanggar barlalu lintas di Kota Bengkulu. Penelitian dilaksanakan disatuan lalu lintas Polres dan Polda Kota Bengkulu. Adapun data yang didapatkan adalah data primer dan data sekunder melalui penelitian lapangan dan penelitian kepustakaan, kemudian data dianalisis dengan cara deskriptif. Peraturan yang tertera pada undang-undang yang tertera sepenuhnya untuk meningkatkan kesadaran untuk setiap pelanggar yang melakukan pelanggaran, tetapi pada kota Bengkulu undang-undang tersebut tidak sepenuhnya berjalan efektif. Menurut pandangan Undang-undang 22 Tahun 2009, penerapan pidana denda masuk dalam kategori pidana pokok (sesuai Pasal 10 KUHP) sebagai urutan terakhir atau keempat, sesudah pidana mati, pidana penjara dan pidana kurungan. Selain dari itu, faktor penghambat keefektifan Undang-undang seperti faktor ekonomi, faktor kedekatan emosional dan faktor kekebalan institusional.Kata kunci: tindak pidana; hukum pidana; dendaABSTRACTThis study aims to determine the application of violators from cities in Bengkulu in terms of Law Number 22 of 2009, and to find out the inhibiting factors in the application of fines to traffic violators in the city of Bengkulu. The research was carried out in the traffic city of the City Police of the City of Bengkulu. The data obtained are primary data and secondary data used for library research and research, then the data are analyzed descriptively. The regulations stated in the law that are fully stated to increase awareness for every offender who commits an offense, but in the city of Bengkulu the law is not fully effective. According to the view of Law 22 of 2009, the application of criminal fines falls into the main criminal category (according to Article 10 of the Criminal Code) as the last or fourth order, after the death penalty, imprisonment and imprisonment. Apart from that, factors inhibiting the effectiveness of the law such as economic factors, emotional proximity factors and institutional immune factors.Keywords: crime; criminal law; fines
MODEL KEBIJAKAN K3 BERBASIS PP NOMOR 11 TAHUN 1979
Authors: Oemara Syarief Amiroel , Ramadhani Wahyu
Published: December 2020

ABSTRAKKecelakaan kerja terjadi bukan hanya karena workplace risk dan masalah manusia (human) tetapi disebabkan oleh pengawasan pemerintah yang masih lemah mengenai penerapan Peraturan Pemerintah mengenai K3. Pemerintah hanya menganggap semuanya akan berjalan lancar apabila sudah memiliki hukum yang tegas. Padahal dalam kenyataannya, penerapan K3 masih sangat kurang meskipun telah memiliki Undang-Undang yang kuat. Tujuan penelitian ini adalah menghasilkan model kebijakan k3 berbasis PP No. 11 Tahun 1979. Penelitian ini berjenis hukum normatif. Hasil yang diperoleh dari penelitian ini adalah dengan adanya model kebijakan berbasis Peraturan Pemerintah Nomor 11 Tahun 1979 Tentang keselamatan kerja pada pemurnian dan pengolahan minyak bumi dan gas pemerintah dapat mengawasi perusahan yang belum membudayakan K3 di perusahaannya sehingga setiap perusahaan lebih mengutamakan kesehatan dan keselamatan kerja bagi setiap karyawan.Kata kunci: model; kebijakan K3; PP Nomor 11 Tahun 1979ABSTRACTAccidents work occurs not only because of workplace risk and human problems but caused by government supervision is still weak regarding the use of government regulation on K3. The Government only considers it all going smoothly when it already has strict laws. The application of K3 is still very lacking despite having a strong constitution. The purpose of this research resulted in a model-based K3 policy No. 11 year 1979. This research is a normative law. The results derived from this research are with the model of government regulation-based policy number 11 year 1979 about occupational safety on the purification and processing of petroleum, and government gases can supervise companies that have not Cultivate K3 in his company so that every company prioritizes health and safety for every employee.Keywords: model policy OSH; PP Number 11 The Year 1979
LA JUSTICIABILIDAD DE LOS DERECHOS ECONÓMICOS, SOCIALES Y CULTURALES: EVOLUCIÓN DE SU APLICACIÓN EN LA CORTE INTERAMERICANA DE DERECHOS HUMANOS
Authors: Galán Melo Gabriel S.
Published: December 2020

El presente ensayo describe —en un primer momento— la problemática en torno a la justiciabilidad de los derechos económicos, sociales y culturales, advirtiendo los posibles supuestos que justifican la no-justiciabilidad y la posición que sobre aquellos puede levantarse a partir de los instrumentos internacionales y regionales de protección de derechos humanos así como de las fuentes de interpretación que han sido desarrolladas por órganos oficiales. En un segundo momento, se describe la aplicación evolutiva del artículo 26 de la Convención Americana de Derechos Humanos en las sentencias de la Corte Interamericana de Derechos Humanos y los estándares utilizados a dicho efecto, a fin de concluir finalmente que los derechos económicos, sociales y culturales son —en efecto— justiciables en dicha corte.
THE MANDIBULAR NERVE, ITS COURSE, ANATOMICAL VARIATIONS AND PTERYGOMANDIBULAR SPACE. - A SYSTEMATIC REVIEW.
Authors: Kumar Manish , Karwasra Kapil , Chhaparwal Amit
Published: December 2020

Knowledge of mandibular nerve and its branches is important when performing dental and surgical procedures of mandible. So, this systematic review article revealed all details of mandibular nerve course and also important anatomical variations. Mandibular nerve during its course go through the pterygomandibular space and this space is important for inferior alveolar nerve block anaesthesia, so all details of pterygomandibular structure are also included in this review.
A PROSPECTIVE RANDOMISED CONTROLLED STUDY FOR EVALUATION OF INTRAPERITONEAL BUPIVACAINE INSTILLATION FOR POST CHOLECYSTECTOMY ANALGESIA
Authors: Singh Siddharth , Jauhari Ramendra Kumar , Mishra Yukteshwar , Singh Sanjay Kumar , Deb Adiveeth
Published: December 2020

Background: Intraperitoneal instillation of local anesthetic agents in laparoscopic cholecystectomy (LC) has been used to reduce postoperative pain and to decrease the need for postoperative analgesia.
Aims: This study aimed to evaluate the effectiveness of intraperitoneal instillation of bupivacaine (0.25%) for post operative analgesia in LC.
Settings and Design: This was a prospective, randomized, single blind study.
Materials and Methods: After obtaining ethical committee’s clearance and informed consent, 204 patients, aged 18–80 years, of either gender, and scheduled for LC were included and categorized into two groups (n = 102). Group A patients received 20 mL of 0.25% bupivacaine intraperitoneally, as well as at trocar site, after cholecystectomy, and Group B patients received the drug only at trocar site.
Statistical Analysis: The data were analyzed using paired t test. The results were analyzed and compared to previous studies. SPSS software version 22 was used, released 2013 (IBM Corp., Armonk, NY, USA).
Results: The Numerical Rating Scale (NRS) score was significantly lower in Group A for the first 8 hours post operatively. Rescue analgesia was given when NRS was more than or 5. Rescue analgesic requirement was also less in Group A for the first 8 hours.
Conclusion: The instillation of bupivacaine intraperitoneally is an effective method of postoperative pain relief in LC. It provided good analgesia in the early postoperative period. Requirement of rescue analgesics was also decreased.
ROLE OF SOCIO-DEMOGRAPHY AND BLOOD PARAMETERS IN SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS
Authors: Paul Debosmita , Parween Wasifa
Published: December 2020

Tuberculosis (TB) disease can progress in a multitude of directions subject to various intrinsic and extrinsic factors on host immune system, starting from genetic insult to nutritional and physiological state of the host. This study was conducted to assess the major socio-demographic characteristics and hematological and biochemical abnormalities for their role in susceptibility to pulmonary tuberculosis. 94 study subjects were enrolled in this study, of which 34 subjects comprised of new case Active Pulmonary TB (PTB), 30 with latent tuberculosis (LTB) and 30 healthy household subjects. All related demographic, socio-economic along with clinical data were collected through a predesigned and pre-tested questionnaire. (2-3) ml blood was drawn from each study subject aseptically for routine blood examination using automated cell counter. The male: female ratio for PTB=2.1:1, LTB=1.3:1, household contacts=0.7:1. Mostly Hindus (97.05% PTB, 90% LTB, 93.33% healthy) with higher proportion of married subjects among all groups (73.53% PTB cases, 70% LTB, 63.33% healthy) observed. 65% of PTB patients were illiterate or educated up to primary level with 40% of both LTB and household contacts with secondary education. 11.76% of PTB patients and 33.33% with LTB had family history of the disease. Prevalence of TB was higher among the poorer strata with 76.47% and 70% respectively in those with PTB and LTB. Male gender, marriage, positive family history and basic-education/illiteracy were found to be associated with disease susceptibility. Anemia and leukocytosis were observed among PTB patients as compared to those with LTB and household contacts.
ROBOT ARM (ADVANCED RISC MACHINE) AUTOMATIC ITEMS TRANSFER BASED ON COLOR USING ARDUINO UNO R3
Authors: Lesmana Dedi , Satria Budy , Sari Yessi Ratna
Published: December 2020

The latest evolution of technology lately had triggered a lot of creativity in our world,especially in robotic in industry. The use of a robot aims to save money and produces product with the same quality.The robot movers and goods is one of the implementation of technology in the field of robotics has the ability to help people to move goods from a place to place that has been made on the color of a grouping of the goods. In this research, robot was designed based on microcontroller 328. Also it is equipped with one DC motors as wheel driver, four servo motors as arm driver, one IR (Obstacle) sensor as an item detector and one TCS3200 sensors as colour.
Experience with the use of microbiological analyzer BactoSCREEN in a routine practice of clinical microbiology laboratory
Authors: Gordeeva Svetlana A. , Zolotarev A.Yu. , Movsisyan M.G. , Rozinko A.V.
Published: December 2020

Objective.

Assessment of bacterial identification effectiveness in clinical microbiology laboratory using the MALDI-MS based system BactoSCREEN.
Materials and Methods.

Bacteriological testing was done by the cultivation on Сolumbia agar with 5% of sheep blood (at 37°C for 24 hours). Colonies for identification were selected based on their growth pattern, type of hemolysis, morphology and consistency. The species identification was done by the MALDI-MS using the microbiology analyzer BactoSCREEN. Apart from MALDI-MS, we used morphology and biochemical methods for species identification when necessary. Serological tests were used for serovar and biovar identifications.
Results.

A total of 85945 bacterial identifications was performed in 2018. When compared to 2017, the throughput of the laboratory increased ten times. A total of 23252 isolates were obtained in the previously mentioned period. A single identification took 2.98–13.22 minutes including time for supporting procedures, whereas the staff time for one identification itself constituted an average of 1.55 minutes. When compared to manual methods, introduction of mass-spectrometry allowed us to achieve 3.5-fold decrease of the staff time in the average. Therefore, annual labor saving in terms of staffing corresponds to 11 full-time positions.
Conclusions.

In view of high throughput, analysis speed, simplicity and low cost of sample preparation, MALDI-MS identification fits well into the practice of clinical microbiology laboratory, especially when large-scale screening studies of bacterial cultures are required. The use of MALDI-MS is likely to be most promising when carrying out microbiological monitoring that is traditionally associated with large number of samples and wide range of microorganisms detected.
FORECASTING THE DEVELOPMENT OF SOCIALLY SIGNIFICANT DISEASES IN THE REGION BASED ON EXPONENTIAL SMOOTHING OF TIME SERIES
Authors: Коровин Евгений Николаевич , Ненашева Алина Николаевна , Сергеева Маргарита Анатольевна
Published: December 2020

В данной статье рассматривается один из подходов прогнозирования и анализа развития социально значимых заболеваний в Тамбовской области с использованием метода экспоненциального сглаживания. Анализ социально значимых заболеваний является одной из важных задач, стоящих перед медициной. С помощью прогнозирования можно разработать план мероприятий по уменьшению уровня развития социально значимых заболеваний. Целью статьи является составления прогноза на 2020-2022 года на основе статистики заболеваемости в период с 2008 по 2019 год для изучения будущей ситуации по развитиюзаболеваний в Тамбовской области. В работе был использован метод экспоненциального сглаживания, так как данный метод является одним из распространённых в прогнозировании, дающий достаточно точный общий прогноз. Результаты прогнозирования были визуализированы в виде графиков и проанализированы. По итогу анализа было выявлено будущее понижение уровня заболеваемости туберкулезом и злокачественными новообразованиями, повышение уровня заболеваемости психическими расстройствами, а также выявлено общее повышение заболеваемости социально значимыми заболеваниями в Тамбовской области. Данное прогнозирование позволит медицинским организациям регионаразработать дальнейшие мероприятия по снижению заболеваемости с учетом динамики роста или уменьшения уровня развития социально значимых заболеваний

This article discusses one of the approaches to predicting and analyzing the development of socially significant diseases in the Tambov region using the exponential smoothing method. The analysis of socially significant diseases is one of the important tasks facing medicine. With the help of forecasting, you can develop an action plan to reduce the level of development of socially significant diseases. The purpose of the article is to make a forecast for 2020-2022 based on morbidity statistics in the period from 2008 to 2019 to study the future situation in the development of diseases in the Tambov region. The method of exponential smoothing was used in the work, since this method is one of the most widespread in forecasting, which gives an accurate general forecast. The results of the forecast were visualized in the form of graphs and analyzed. The analysis revealed a future decrease in the incidence of tuberculosis and malignant neoplasms, an increase in the incidence of mental disorders, as well as a general increase in the incidence of socially significant diseases in the Tambov region. This forecasting will allow medical organizations in the region to develop further measures to reduce morbidity, taking into account the dynamics of growth or decrease in the level of development of socially significant diseases