bluuebunny/crossref_metadata_2025 huggingface dataset:
Adhesive Strength of Glass Fiber-Reinforced Posts with Silane Conditioning Versus Universal Adhesive System Conditioning: An In Vitro Study
Authors: Martínez-Campos Reynaldo , Vilchez-Reynaga Luzmila , Santander-Rengifo Flor , López-Gurreonero Carlos , Aliaga-Mariñas Ana , Aroste-Andía Rosa , Cayo-Rojas César
Published: August 2024

Aim:

The current study compared the push-out adhesive strength of glass fiber-reinforced posts with a silane-treated surface versus a universally adhesive-treated surface. In both cases, a universal self-adhesive cement was used.

Materials and Methods:

Thirty bovine teeth were used in an in vitro experiment. Through cutting, the root and coronal sections were divided. Subsequently, the manufacturer’s recommendations were followed for the placement of glass fiber-reinforced posts through root canal therapy, gutta-percha removal, and canal shaping. On the basis of how the posts were treated prior to cementation, the samples were split into three groups (n = 10). Posts in group A (control) did not get any prior treatment. Posts in group B had previously received a silane treatment. Posts in Group C had previously been coated with universal adhesive. Following the application of RelyX Ultimate universal self-adhesive cementation, the samples were segmented and subjected to a Push-Out test at a speed of 1 mm/min on a universal testing apparatus. Intergroup ANOVA was used to evaluate the adhesive strength means (measured in MPa), and Tukey’s post hoc test was performed afterward, with a significance level of P < 0.05.

Results:

Compared to the glass fiber-reinforced posts pre-treated with silane (P = 0.003) and the control group (P < 0.001), the adhesive strength of the posts pre-treated with universal adhesive was significantly higher. Similarly, the adhesive strength of the glass fiber-reinforced posts that had been pre-treated with silane was considerably higher than that of the control group (P = 0.012).

Conclusion:

Posts reinforced with glass fiber and pre-treated with universal adhesive exhibited notably greater adhesive strength compared to those pre-treated with silane. When compared to utilizing universal self-adhesive cement without pre-treatment, both pre-treatment techniques greatly increased the adhesive strength of glass fiber-reinforced posts.
Prenatal Ultrasound and Magnetic Resonance Findings of Glutaric Acidemia Type 1 and Its Challenges in Prenatal Diagnosis
Authors: Wang Jo-Ting , Lee Han-Jui , Chang Tung-Yao
Published: August 2024

Glutaric acidemia type 1 (GA1) presents unique challenges in prenatal diagnosis, especially in cases with no family history. This review article aims to review and present the prenatal ultrasound and magnetic resonance findings of GA1 and consolidate key insights into the difficulties associated with GA1 prenatal diagnosis and the neuroimaging features that require careful differentiation during the diagnostic process.
The effect of prone positioning on surgical pleth index in patients undergoing spine surgery under general anesthesia – A prospective observational study
Authors: Musti Smita , Chakrabarti Dhritiman , Bansal Sonia
Published: August 2024

Background and Aims:

Surgical Pleth Index (SPI) provides an objective assessment of nociception - anti-nociception balance but is influenced by multiple confounders. The effect of change of position on SPI, has not been studied extensively. The aim of the study was to observe the effect of prone positioning on SPI and its correlation with hemodynamic variables, in patients undergoing lumbar and thoracic spine surgery.

Material and Methods:

This prospective observational pilot study included 14 patients. In addition to hemodynamic monitoring, SPI, entropy and pulse pressure variability (PPV) were monitored. Propofol and Fentanyl infusions were used for maintenance of anesthesia. The patients were made prone on bolsters and all the variables were recorded every 5 minutes in supine position and after making prone for 20 minutes, before and after incision, muscle splitting and laminectomy.

Results:

Comparing the last value of the variables in the supine position with those immediately after making prone, SPI increased by 16.36 units (P = 0.003), followed by gradual reduction over the next 20 minutes. Mean arterial pressure and heart rate increased transiently (Pvalue = 0.028 and 0.025, respectively) without any significant change in PPV. Surgical incision also led to a significant increase in SPI.

Conclusion:

Prone positioning leads to significant increase in SPI, probably due to increased sympathetic tone.
Oropharyngeal Cancer in a Thalassemic Patient: Role of Iron Overload in Carcinogenesis
Authors: Sahu Swarnita , Halder Shikha , Hukku Shelley , Atul Tyagi
Published: August 2024

ABSTRACT

The thalassemia syndromes are inherited α and β globin biosynthesis disorders. Patients with β thalassemia major require intensive blood transfusions to survive. Chronic blood transfusions can lead to blood-borne infections, alloimmunization, febrile reactions, and lethal iron overload. With the recent advances in treatment approaches and improvements in chelation therapy, thalassemic patients are living longer. Because of this, new complications are emerging, the majority of which are related to the treatment, and few are related to the primary pathology. One of the rarely reported complications is malignancy. The role of iron in carcinogenesis is still debatable. The role of iron in colorectal, liver, kidney, lung, and stomach cancer either as a cancer initiator or as a promoter is well documented. The most probable causes are iron autooxidation, pro-inflammatory cytokines activation of oxidative responsive transcription factors, and iron-induced hypoxia signaling. However, there is hardly any literature mentioning the role of iron in head-and-neck cancers. We report a case of oropharyngeal cancer in a thalassemia patient and discuss the possibility of association between the two diseases with emphasis on the aggressiveness of the cancer in the background of thalassemia and iron overload.
Anesthesia and its environmental impact: approaches to minimize exposure to anesthetic gases and reduce waste
Authors: Samad Khalid , Yousuf Muhammad Saad , Ullah Hameed , Ahmed Syed Shabbir , Siddiqui Khalid Maudood , Latif Asad
Published: August 2024

In today’s era of modern healthcare, the intersection between medical practices and environmental responsibility has gained significant attention. One such area of focus is the practice of anesthesia, which plays a crucial role in various surgical procedures. Anesthetics such as nitrous oxide and volatile halogenated ethers (desflurane, isoflurane, sevoflurane) are examples of medical gases that are strong greenhouse gases that contribute to global warming. During medical procedures, most of these anesthetic agents are released into the atmosphere, which exacerbates their influence on the environment. Also anesthesia delivery systems have traditionally utilized high flow rates of gases, leading to not only excessive consumption but also a considerable environmental impact in terms of greenhouse gas emissions. However, the emergence of low-flow anesthesia (LFA) presents a promising solution for achieving emission reduction and cost savings, thereby aligning healthcare practices with sustainability goals. Understanding LFA involves the administration of anesthetic gases to patients at reduced flow rates compared to conventional high-flow methods. This practice requires precision in gas delivery, often incorporating advanced monitoring and control systems. By optimizing gas flow to match the patient’s requirements, LFA minimizes wastage and excessive gas release into the environment, subsequently curbing the carbon footprint associated with healthcare operations. Decreasing volatile anesthetic delivery provides safe and effective strategies for anesthesia providers to decrease costs and reduce environmental pollution. Current literature support in favor of LFA represents an area of cost containment and an opportunity to lessen the environmental impact of anesthesia. This article will cover the concept of LFA, the distinctions between low flow and minimal flow, and the potential advantages of LFA, such as those related to patient safety, the environment, and the economy.
Overview of obesity and effect of bariatric surgery in Aljouf area, Saudi Arabia
Authors: Felemban Hana Bahraldeen , Mutlaq Baseem Saber , Hamoud Alhassan Ismail , Ziyad Alluheed Mohamad , Takia Yousfi Iman , Abdulkarim Alolayan Mohammed , Ibrahim Albahooth Khalid , Zaki Alsharari Abdulrahman
Published: August 2024

Introduction:

Studies have shown that obesity is increasingly prevalent in Saudi Arabia (SA). As the nation has witnessed economic growth and associated lifestyle changes, obesity has emerged as a significant problem, according to the findings of Salem et al. in 2022. Although obesity has reached a prevalence of 41.1% in males and 77.6% in females in SA,research on this topic has been lacking.

Aim:

To highlight the prevalence of obesity in Aljouf area and demonstrate the effect of bariatric surgery on patient health.

Methods:

We conducted a retrospective chart review using relevant demographic and clinical data from 2020 onward collected from the Arcus Air system. Statistical analysis: Descriptive statistical analysis was performed, and numerical data were presented as median (interquartile range [IQR]) and categorical data as frequencies and percentages. Numerical variables were tested for normality using the Shapiro-Wilk normality test. Statistical significance was set at P<0.05 were considered significant. STATA® 15.1 was employed for the analysis.

Results:

We included 196 patients who underwent bariatric surgery. Their median age was 34 years (range,17–52), and females constituted 65% . Approximately 80% of the study subjects had a baseline body mass index (BMI) of >40kg/m2, and approximately 13% had diabetes mellitus (DM). Ten days after surgery, a significant decline was observed in the median BMI of 39.3 (37.3–41.4) compared to the pre-operative median BMI of 42 (40–44 ). A further significant decrease was observed in BMI three months later (median BMI: 33.7 [31–36.98]). This was paralleled by improvement in HbA1c levels in patients with DM or pre-diabetes, with a median value of 5.5% (5.4–6.6) three months after surgery compared to a baseline median of 6.6% (6.2–7.4).

Discussion:

The data demonstrated that obesity was more prevalent in females than males. We observed a statistically significant change in weight loss based on BMI in the first ten days following the procedure (39; 37.2–41.3) and again at the three-month follow-up (33.7; 31–36.98), P <0.0001. Patients with comorbidities such as DM and hypertension showed significant health improvements, unlike those with high high-density or low-density lipoprotein levels.

Conclusion:

Bariatric surgery is an effective approach to weight reduction in patients with obesity. The study demonstrated significant reductions in comorbidities (DM and HTN), in addition to overall health improvements. There is a need to raise awareness of obesity’s effects on society. Further studies are required in northern regions.
A comprehensive review on creating curricula to teach robotic surgery
Authors: Kaaki Suha K.
Published: August 2024

Since 2017, robotic-assisted surgery has significantly grown, enabling surgeons to overcome weaknesses interrelated to traditional laparoscopic surgery. Therefore, the high growth of robotic-assisted surgery has necessitated the development of a curriculum that will support effective learning of this technology. Although different curricula have been developed and validated over the years, researchers have different views on their effectiveness; some of them reveal that some are better than others. This review aims to highlight and discuss numerous curricula that have been developed to teach robotic-assisted surgery. In understanding the creation of curricula that can be used to teach robotic surgery, comprehensive searches of literature materials from PubMed, MEDLINE and Embase were conducted. After the investigation, research articles on robotic surgery curricula published in English from 2014 to 2022 were located and used. Based on the research materials, it was established that creating and implementing a standard curriculum incorporating simulation training, mentorship, didactic lessons, and hands-on practice is one of the best when applied in robotic surgery training. This is because it shows a significant improvement in didactic, cognitive, psychomotor, and communication skills when implemented. Besides, the results indicated that other curriculum programs such as da Vinci® Technology Training Pathway and Fundementals of Robotic Surgery are crucial in creating a curriculum to teach robotic surgery since they influence procedure-specific skills and knowledge, including but not limited to instrumentation, patient selection, system and patient positioning, preoperational operation, procedural steps, port placement, management, and complications. Therefore, this shows that to achieve the most effective training curricula for robotic surgery, it is vital to combine several teaching methods for surgeons to achieve great expertise.
Incidental finding of carcinoid tumor postappendectomy and a review from Gulf Cooperation Council countries
Authors: Alotaibi Abdulrahman Muaod , Alfaiel Emad Ahmed , Alsatouf Khaled Aabdulmawla , Aloufi Ayah , Moshref Leena Hatem
Published: August 2024

Scanty of research in Gulf Cooperation Council countries address the neuroendocrine tumors (NETs) with a gap in reported cases after appendectomy in Saudi Arabia compared to others. This study aimed to describe the experience of a single tertiary care private hospital in the management of incidentally discovered NETs after appendectomy and to review the series from nearby countries. A retrospective data review was done between January 2016 and January 2018 in the Surgery Department at Dr. Soliman Fakeeh Hospital (Jeddah, Saudi Arabia). Among 458 appendectomies, 3 appendiceal carcinoid tumors were identified (0.67%). All patients present with acute appendicitis. The carcinoid tumor was not diagnosed preoperatively. The mean diameter of the appendix was 10 mm, while the histopathology diameter of the discovered carcinoid was 5 mm. There were no postoperative complications. All patients were disease-free at follow-up. None of them received reoperation or adjuvant therapy.
Sayburç a mid-9th millennium BC site in the foothills of the Eastern Taurus
Authors: Özdoğan Eylem
Published: August 2024

A Pre-Pottery Neolithic site at Sayburç is currently being studied as part of the Şanlıurfa Neo-lithic Research Project – Taş Tepler (Türkiye), which is focused on the Neolithic Period at the Şanlıurfa Plateau. The settlement belongs to the early sedentary societies on the plateau, characterized by monumental buildings, T-shaped pillars, and rich symbolic elements that distinguish the region from its contemporaries in Southwest Asia. A growing body of evidence indicates that rituals and the associated symbolism and narratives play a pivotal role in the formation of the region’s early sedentary societies. The construction of special buildings in Sayburç, situated close to dwellings and accompanied by associated symbolism, illustrates the intertwining of the sacred with everyday life. This paper presents the preliminary results of the first three years of research on the site and discusses the cultural dimension of the region itself.
Imaging approach for jaw and maxillofacial bone tumors with updates from the 2022 World Health Organization classification
Authors: Choi Woongsoon John , Lee Peggy , Thomas Penelope C , Rath Tanya J , Mogensen Monique A , Dalley Roberta W , Wangaryattawanich Pattana
Published: August 2024

Jaw and maxillofacial bone lesions encompass a wide variety of both neoplastic and non-neoplastic pathologies. These lesions can arise from various tissues, including bone, cartilage, and soft tissue, each presenting distinct challenges in diagnosis and treatment. While some pathologies exhibit characteristic imaging features that aid in diagnosis, many others are nonspecific. This overlap often necessitates a multimodal imaging approach, combining techniques such as radiographs, computed tomography, and magnetic resonance imaging to achieve a diagnosis or narrow the diagnostic considerations. This article provides a comprehensive review of the imaging approach to jaw and maxillofacial bone tumors, including updates on the 2022 World Health Organization classification of these tumors. The relevant anatomy of the jaw and dental structures that is important for accurate imaging interpretation is discussed.
Effect Of Organizational Culture And Empowerment On Organizational Commitment To Improve Employee Performance In Puskesmas Ngemplak 1
Authors: Wulandari Astrilia , Subiyanto Didik , Herawati Jajuk
Published: August 2024

This study examines the effect of Organizational Culture and Empowerment on Organizational Commitment to improve Employee Performance at Puskesmas Ngemplak 1. This research was conducted on all employees of Puskesmas Ngemplak 1, totalling 40 people. This research is quantitative. The sample of this study used a sampling technique with a questionnaire or questionnaire. The sample data collection was carried out by distributing questionnaires directly to each employee. The number of questionnaires distributed and processed was as many as 20 questionnaires. Data processing in this study uses multiple linear regression analysis techniques, assisted by the SPSS program version 20.0. The results of this study indicate that organisational culture has a positive and significant effect on organisational commitment. Organisational culture has a positive and significant impact on performance. The empowerment of members has a positive and significant impact on organisational commitment. Assignment of members has a positive and significant effect on performance, and organisational commitment also positively and significantly impacts performance. This proves that organisational culture and member empowerment on organisational commitment significantly affect the performance of the employees of Puskesmas Ngemplak 1
Organizational Culture and Employee Competence on Employee Performance to Improve Service Effectiveness in the North Sumedang Public Health Center
Authors: Hidayat Ardi , Chaerudin Abdul Rauf , Kurniawanto Hadi
Published: August 2024

This study aims to analyze the Influence of Organizational Culture And Competence Of Employees To Improve Employee Performance Effectiveness Environmental Health Center Services In North Sumedang Sumedang The method used is descriptive analysis, variables consisted of independent variables that Organisation Culture And Employee Competence, variable between the employee performance, the dependent variable is Effectiveness Service. The study population was Kaler City Employee Health Center and the Employee Health Center as 75orang Situ. The sampling is done using the Census, where the entire population of as many as 75 people were made respondents in the study. Data were collected with a documentary study and field study through observation, interviews and questionnaires and data analysis techniques using statistical analysis with path analysis model (path analysis). The results of the study hypothesis testing obtained evidence that Organizational Culture and Employee Competence real and positive impact on employee performance to Improve Effectiveness of Environmental Health Center Services In North Sumedang Sumedang that is equal to 84%. While the influence of outside variables Employee Performance and Effectiveness Service is at 16%, that other factors not examined or epsilon factor. For further advice given author to convey the presence of some of the findings in the study and because of the limited time in research, it is expected to come advisable to conduct further research on organizational culture, employee competency, employee performance and effectiveness of services and different perspectives through a disciplined approach good knowledge of Public Administration and other disciplines
MODEL MATEMATIKA DINAMIKA HARGA CRYPTOCURRENCY
Authors: Yonesa Salsabila , Subhan Muhammad
Published: August 2024

Current technological developments have digital money or cryptocurrency which is currently being used as an investment by the world community. here are views about cryptocurrencies, there is a profitable opportunity by involving cryptocurrencies into the economy and monetary system. The aim of this research is to form a cryptocurrency price dynamics model, analyze the stability of the equilibrium point and interpret the results of the model simulation. This type of research is basic or theoretical research. The method used is a descriptive method. This dynamic model takes the form of a system of differential equations consisting of five equations. In the analysis of the dynamic model, it was found that one equilibrium point was unstable because it did not meet the requirements. Based on the analysis of the simulation results that have been carried out, it shows that cryptocurrency prices deviate from fundamental values with the encouragement of liquidity prices resulting in cryptocurrency prices deviating from the equilibrium point
O protagonismo de Rita Lee na subversão do amor romântico
Authors: Anaz Sílvio Antonio Luiz
Published: August 2024

As canções de Rita Lee contribuíram para alimentar o imaginário do rock nacional em temas como a celebração da liberdade, da rebeldia e do que é profano. Além de trazer esses temas, seu trabalho contribuiu para adicionar um elemento original: a erotização do amor romântico. Aborda-se aqui, a partir da análise de alguns de seus principais sucessos, o protagonismo da artista na subversão das canções de amor que predominavam no pop-rock brasileiro.
Goiânia, 90 anos
Authors: Pinto Junior Rafael Alves
Published: August 2024

Resenha do livro: OLIVEIRA, Eliézer Cardoso de; MENDONÇA, Jales Guedes Coelho; CHAUL, Nasr Fayad; JAIME, Nilson. Goiânia, 90 anos. Goiânia: Edições Goiás + 300, 2024. 336 p.
Euclides da Cunha
Authors: Teixeira Daher Anna Paula
Published: August 2024

Texto crítico sobre a vida e obra de Euclídes da Cunha.
Pareceristas desta Edição
Authors: Editores de albuquerque: revista de história
Published: August 2024

Pareceristas dos manuscritos submetidos pelo sistema de avaliação revisão por pares duplo-cego.
Is the development of arrhythmia predictable in rheumatoid arthritis?
Authors: Gülkesen Arif , Yıldırım Uslu Emine , Akgöl Gürkan , Alkan Gökhan , Ali Kobat Mehmet , Ali Gelen Mehmet , Fuad Uslu Muhammed
Published: August 2024

Objectives: This study aimed to determine whether there is a difference in the electrocardiography (ECG) measurements of healthy controls and rheumatoid arthritis (RA) patients and to predict whether they can be used to determine the risk of arrhythmia in patients.

Patients and methods: The prospective study included 50 cardiac asymptomatic RA patients (38 males, 12 females; mean age: 46.8±9.1 years; range, 18 to 60 years) who met the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology RA criteria and 50 healthy volunteers (34 males, 16 females; mean age: 43.4±10.4 years; range, 18 to 60 years) as a control group between June 1, 2022, and August 31, 2022. Disease activity of the patients was calculated with the Disase Activity Score (DAS28). Heart rate, minimum and maximum QT intervals, QT dispersion, minimum and maximum P waves, P wave dispersion (Pd), minimum and maximum Tp-e intervals, Tp-e dispersion, minimum and maximum corrected QT (QTc) intervals, QTc dispersion, and the Tp-e/QTc ratio in ECGs were calculated.

Results: The mean disease duration of the RA group was 9.09±5.74 years. The mean C-reactive protein level was 9.83±8.29, the mean erythrocyte sedimentation rate was 26.12±16.28 mm/h, and the mean DAS28 was 3.03±0.37. There was a statistically significant increase in the maximum P wave, Pd, maximum QT, QT dispersion, maximum QTc, QTc dispersion, maximum Tp-e, Tp-e dispersion, and Tp-e/QTc dispersion parameters in the RA group compared to the control group, while there was a significant decrease in the minimum P wave, minimum QT, and minimum QTc parameters.

Conclusion: In our study, the Pd, QTc dispersion, Tp-e dispersion, and Tp-e/QTc dispersion values of our patients, which indicate the risk of atrial and ventricular arrhythmia, were found to be significantly higher. This finding suggests that our patients had an increased risk of cardiac morbidity and mortality. Arrhythmias are the likely source of the increase in sudden cardiac death in RA, and these new indicators measured on ECG can be used as standardized cardiovascular morbidity and mortality indicators in the future.
DEVELOPMENT OF PREDICTION MODELS FOR COMPRESSIVE STRENGTH IN CEMENT MORTAR WITH BENTONITE USING MACHINE LEARNING TECHNIQUES
Authors: Altuncı Yusuf Tahir , Saplıoğlu Kemal
Published: August 2024

In this study, the effects of bentonite-substituted cement mortar, cement compressive strength, cement quantity, spread values, water absorption percentages by weight, and porosity values on the 28-day compressive strength were investigated using Multiple Regression, Adaptive Neuro-Fuzzy Inference System and the intuitive optimization method known as Particle Swarm Optimization. Based on the results obtained from 18 data points, with 4 of them used for testing and 14 for training, effective and ineffective input parameters were identified in comparison to Multiple Regression. Subsequently, Particle Swarm Optimization and Adaptive Neuro-Fuzzy Inference System main models were designed according to the obtained results. As a result of the study, it was determined that cement compressive strength, cement quantity and water absorption parameters have a higher impact on compressive strength compared to other parameters. It was found that the best accuracy model was achieved with the Particle Swarm Optimization model, and the results of the Multiple Regression model can also be used in predicting outcomes.
When Digitalization Meets Regulation across Borders: An Explainer with Actionable Insights
Authors: Coche Eugenie , Kolk Ans
Published: August 2024

A flurry of regulations has emerged across the world to govern the use, transfer and storage of data, affecting digital and traditional firms, of all sizes. To guide business practitioners and educators, this article provides insights into key components of digital laws and what they mean for different types of firms. We take the European Union as starting point, given its prominent and extra-territorial rule-setting, but also reflect on other cross-border (future) digital regulations. Our analysis of relevant details reveals a need for practitioners to be prepared and forward-looking, considering firms’ specifics, internationally converging ethical principles and (future) digitally-aware generations.
THE EFFECT OF CORPORATE SOCIAL RESPONSIBILITY & CAPITAL STRUCTURE ON COMPANY VALUE MODERATED PROFITABILITY AND FIRM SIZE
Authors: Jesslyn Claresta , Budidarma I Gusti Agung Musa
Published: August 2024

The purpose of this study is to analyze the influence of corporate social responsibility (CSR) and capital structure on company value with profitability and firm size as moderation variables. This study uses secondary data in the form of annual reports on the non-primary consumer, transportation, industrial, energy, health, and technology sectors listed on the Indonesia Stock Exchange in 2021 - 2023. The sample of companies studied is 154 companies with 462 data. The results show that the combination of independent variables, profitability as moderating variables, and the interaction of independently variable with moderation can affect the company's value by 71.79%. The significance values of CSRE, DAR, SIZE, CSR with firm size (CSRE x SIZE) and Capital Structure With Firm Size (DAR x SIZE) have values of 0.3724, 0.6024, 0,3405, 0.4334, and 0.6602 > 0.05. The combination of independently variables, profitability, and capital structures with firm sizes have values 0.1827, 0.3435, 0.4335, and 0.663, respectively. The impact of CSR on firm value is moderated by profitability, while firm size moderates the influence by capital structure. Furthermore, examining the role of different types of CRS activities or varying approaches to capital structure could provide insights into why certain strategies might succeed or fail in enhancing company value.
POTENSI PENGGUNAAN TANAMAN ANTING-ANTING (Acalypha indica L) SEBAGAI ZAT AKTIF PADA PEMBUATAN LIP BALM DAN SEDIAAN KOSMETIK LAINNYA
Authors: Suhesti Iin , Hariyani Anisa , Hidayah Aisyah Nur , Sahara Arofah Frisca
Published: August 2024

Lip balm merupakan salah satu produk kosmetik yang paling sering digunakan saat ini, terutama oleh kaum wanita. Tujuan penggunaan lip balm yaitu untuk melembabkan bibir dan mengurangi bibir pecah-pecah. Tetapi banyak sediaan lip balm yang menggunakan bahan kimia berbahaya sehingga dapat mengakibatkan bibir menjadi hitam, iritasi sampai ke kanker kulit, sehingga diperlukan lip balm yang menggunakan zat aktif dari bahan alam salah satunya adalah tanaman Anting-anting (Acalypha indica L). Penelitian ini dilakukan dengan metode narative review yang bertujuan untuk mengetahui potensi penggunaan tanaman anting-anting (Acalypha indica L) sebagai zat aktif pada pembuatan lip balm dan sediaan kosmetik lainnya. Hasil dari beberapa literatur diperoleh golongam flavonoid yang berhasil diidentifikasi dari tanaman anting-anting (Acalypha indica L) adalah isoflavon, flavon, flanolol, flavanon, dihidroksiflavonol, khalkon dan antosianidin. Ditemukan juga kandungan antioksidan dengan persen inhibisi (IC50) menggunakan pelarut etanol fraksi TH, HB, HA secara berturut-turut adalah 127,87 ppm; 132,97 ppm; dan 133,68 ppm dengan kategori sedang. Sedangkan dengan pelarut heksana, kloroform dan methanol diperoleh aktivitas antioksidan yang signifikan dengan nilai IC50 yaitu 6,19 ± 0,010 mg/ml; 5,70 ± 0,050 mg/ml; dan 7,79 ± 0,020 mg/ml. Kadar antioksidan pada daun dengan konsentrasi 200, 400, dan 600 μg yaitu 17,12%; 26,87%; dan 31,14%. Sedangkan pada akar dengan konsentrasi 200, 400, dan 600 μg yaitu 26,16%; 41,84%; dan 53,27%. Berdasarkan kandungan flavonoid dan antioksidan, tanaman anting-anting (Acalypha indica L) berpotensi sebagai zat aktif pada pembuatan lip balm dan sediaan kosmetik lainnya.
EFEKTIVITAS PENYULUHAN KESEHATAN RAMUAN JAMU SAINTIFIK UNTUK PENURUN KADAR ASAM URAT PADA IBU-IBU PKK DI DUKUH BASIN KEBONARUM KLATEN
Authors: Swaraswati Annisa , Dewi Indri Kusuma , Kirwanto Agus
Published: August 2024

Berdasarkan hasil Riskesdas tahun 2013, prevalensi penyakit sendi berdasarkan gejala yaitu NTT (33,1%), Jawa Barat (32,1%) dan Bali (30%). Penggunaan tumbuhan yang ada di Indonesia sangat minim karena kurangnya dukungan terhadap program saintifikasi jamu. Masyarakat belum mengetahui ramuan jamu saintifik sebagai penurun kadar asam urat. Berdasarkan hasil studi pendahuluan, mayoritas warga Dukuh Basin belum mengetahui ramuan jamu saintifik (daun kepel, herba tempuyung, kayu secang, herba meniran, kunyit dan temulawak) sebagai penurun kadar asam urat. Penelitian ini bertujuan untuk mengetahui efektivitas penyuluhan kesehatan ramuan jamu saintifik untuk penurun kadar asam urat pada Ibu-ibu PKK di Dukuh Basin. Penelitian ini menggunakan quasi eksperiment design dengan rancangan one grup pretest posttest. Populasi dalam penelitian ini adalah Ibu-ibu PKK di Dukuh Basin dengan teknik purposive sampling. Instrumen yang digunakan berupa angket. Hasil penelitian didapatkan nilai mean pretest 69,51 dan posttest 97,44 dengan selisih nilai mean 27,92. Hasil analisis bivariat menggunakan t-test P=0,000 (P<0,05) yang menunjukan bahwa ada pengaruh yang signifikan antara peningkatan pengetahuan sebelum penyuluhan dan sesudah penyuluhan. Kesimpulan dari penelitian ini adalah penyuluhan kesehatan tentang ramuan jamu saintifik untuk penurun kadar asam urat efektif terhadap peningkatkan pengetahuan Ibu-ibu PKK di Dukuh Basin.
FORMULASI DAN UJI FISIK SEDIAAN SALEP EKSTRAK DAUN JAMBU AIR (Syzygium aqueum (Burm F.) Alston) DENGAN VARIASI TIPE BASIS SALEP
Authors: Permatasari Yunita Dian , Kirani Nava , Nafisah Umi , Dewi Aptika Oktaviana Trisna
Published: August 2024

Water guava leaves contain chemical compounds such as flavonoids, tannins and saponins. As a medicinal preparation, water guava leaves can be made into an ointment. This study aims to determine the ointment formulation, conduct physical evaluation of the ointment and determine the effect of different types of ointment base extracts of water guava leaves on physical properties. Water guava leaves extract was made by maceration method of ethanol 70% solvent.  Ointment are made with four types of bases which include hydrocarbon base, absorption, water washed and water soluble. Each formula was tested for physical properties including organoleptic, homogeneity, pH, dispersal, and adhesion. The data obtained were then analyzed using the One Way ANOVA test method. The results showed that the four ointment formulas had different shapes and colors, had the same odor and had good homogeneity. The pH test of the hydrocarbon bases ointment was 4.09, the absorption bases was 3.98, the water-washed bases was 4.33, and the water-soluble base was 3.87 did not meet the pH test parameters. The dispersibility test results for hydrocarbon bases 6.20 cm, absorption basis 6.19 cm met the test parameters, base ointment was washed with water 3.99 cm, water soluble base 3.49 cm did not meet the dispersibility test parameters. The results of  the adhesion test for hydrocarbon bases 11.85, absorption bases 12.11, water washable bases 20.03, and water soluble bases 4.97, which means they meet the adhesion test parameters. The results of the  One Way ANOVA test showed that the pH test, spreadability and adhesion had the same significant value, namely 0.000 <0.05. These results indicate that the different types of ointment bases used  have a significant effect on pH, dispersion and adhesion.
TINGKAT PENGETAHUAN KONSUMEN TENTANG SWAMEDIKASI PENGGUNAAN OBAT BEBAS DAN OBAT BEBAS TERBATAS DI TOKO OBAT BERIJIN LUWES WONOGIRI
Authors: Darojati Ulfa Afrinurfadhilah , Dewi Alminati Sari
Published: August 2024

Pengobatan sendiri atau yang disebut dengan pengobatan sendiri merupakan upaya yang paling banyak dilakukan oleh masyarakat untukmengatasi gejala penyakit sebelum mencari pertolongan ke tenaga kesehatan. Prevalensi dari pengobatan sendiri cenderung meningkat di kalangan masyarakat untuk mengatasi gejala atau penyakit yang dianggap ringan. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan tentang swamedikasi penggunaan obat OTC dan OTC Terbatas pada konsumen di Toko Obat Perizinan Luwes Wonogiri. Penelitian ini dilakukan dengan menggunakan metode survei deskriptif, yaitu metode penelitian yang mengambil sampel dari suatu populasi dan menggunakan formulir google yang didistribusikan melalui tautan. Data diperoleh dari kuesioner, diolah dengan Microsoft Office Excel. Hasil data dari kuesioner diolah menggunakanMicrosoft Office Excel. Sampel dalam penelitian ini sebanyak 126 responden. Penelitian dilakukan kepada konsumen dalam rentang usia 17-50 tahun yang mengunjungi Obat Luwes Toko Wonogiri. Sebanyak 75 responden berusia antara 17-25 tahun, 50 responden berusia 26-40 tahun, dan 1 responden berusia >40 tahun. Penelitian menunjukkan bahwa ada 44,44% orang memiliki kebaikanpengetahuan, 44,44% masyarakat memiliki pengetahuan cukup baik, dan 11,11% memiliki pengetahuan kurang. Kesimpulan dari penelitian ini adalah tingkat pengetahuan konsumen tentang pengobatan sendiri obat bebas dan obat bebas terbatas di Toko Obat Perizinan Luwes Wonogiri bagus.
PEMBUATAN DAN VALIDASI KUESIONER EVALUASI PENERAPAN PERMENKES NOMOR 73 TAHUN 2016 DI APOTEK SWASTA KOTA TARAKAN
Authors: Rukaya Benazir Evita , Syuhada Syuhada , Mustika Tahuti
Published: August 2024

Standar pelayanan kefarmasian merupakan tolak ukur yang digunakan sebagai pedoman bagi tenaga farmasi dalam penyelenggaraan pelayanan di Apotek. Dimana kualitas pelayanan dapat dievaluasi dan dinilai berdasarkan tingkat kepuasan dari pengguna jasa layanan. Untuk mengukur tingkat kepuasan tentunya membutuhkan instrumen yang valid dan reliabel agar hasil yang diberikan konsisten dan dapat dipercaya. Tujuan dari penelitian ini adalah untuk membuat kuesioner yang relevan dengan Permenkes nomor 73 Tahun 2016 dan tentunya telah diuji validitas dan realibilitasnya. Penelitian ini merupakan penelitian analisis deskritif kualitatif, dengan menggunakan teknik purposive sampling dalam penentuan responden. Penilaian dilakukan dengan membagikan kuesioner kepada 8 responden yang merupakan apoteker. Adapun metode penyebaran kuesioner yang digunakan adalah metode tes ulang atau test-retest-method. Metode tersebut merupakan metode yang dilakukan lebih dari satu kali yaitu hari ke-1, 3 dan 6, menggunakan instrumen yang sama, kemudian hasil dari tes tersebut dikorelasikan menggunakan Software SKALO V.0.4. dan Software SPSS untuk menilai validitas dan realibilitas instrument yang digunakan. Hasil dari uji validitas dan reabilitas kuesioner ini dinyatakan valid dan reliabel dimana berdasarkan pendapat dari 8 responden yang ada juga menyatakan bahwa kuesioner ini relevan dengan Permenkes Nomor 73 Tahun 2016. Sehingga dapat disimpulkan bahwa kuesioner ini dapat menjadi alternatif  pilihan untuk dijadikan alat ukur evaluasi pelayanan kefarmasian di Apotek karena telah dinyatakan valid, reliabel dan relevan dengan Permenkes Nomor 73 Tahun 2016.
TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK MITRA SEHAT ANDA PURWANTORO
Authors: Amalia Annora Rizky , Wulandari Deny Balita
Published: August 2024

Apotek adalah sarana pelayanan kefarmasian tempat apoteker melakukan praktik kefarmasian. Pelayanan kefarmasian merupakan salah satu bentuk pelayanan kesehatan di apotek dan merupakan satu kesatuan yang tidak terpisahkan yang berperan penting dalam meningkatkan kualitas hidup pasien dan juga meningkatkan kepuasan pasien. Kepuasan pasien merupakan bagian penting dari pelayanan kefarmasian karena dapat digunakan untuk mengukur kualitas pelayanan. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di Apotek Mitra Sehat Anda Purwantoro. Penelitian ini dilakukan dengan menggunakan metode survei deskriptif, yaitu metode penelitian yang mengambil sampel dari suatu populasi dan menggunakan kuesioner sebagai alat pengumpulan data. Sampel dalam penelitian ini adalah 100 responden. Kuesioner terdiri dari 18 pertanyaan yang telah dinyatakan reliabel dan valid, mengukur tingkat kepuasan pasien berdasarkan 5 dimensi yaitu reliabilitas, daya tanggap, jaminan, empati dan bukti nyata. Hasil penelitian menunjukkan bahwa tingkat kepuasan pada dimensi keandalan adalah 82% (sangat puas), daya tanggap 83,67% (sangat puas), jaminan 84,5% (sangat puas), empati 83,33% (sangat puas), dan berwujud 82,75% (sangat puas). Dengan rata-rata semua dimensi menunjukkan nilai sebesar 83,25%. Kesimpulan dari penelitian ini adalah tingkat kepuasan pasien terhadap pelayanan kefarmasian di Apotek Mitra Sehat Anda Purwantoro sangat puas.
KESESUAIAN PERESEPAN OBAT PASIEN KRONIS BPJS RAWAT JALAN POLIKLINIK JANTUNG TERHADAP FORMULARIUM NASIONAL DI RSU ASTRINI WONOGIRI
Authors: Wigatiningtyas Ariska , Utami Dwi Setyowati
Published: August 2024

Resep yang diberikan kepada pasien di era Jaminan Kesehatan Nasional (JKN) harus mengacu pada Formularium Nasional. Disparitas penulisan resep dengan Formularium Nasional akan berdampak pada mutu pelayanan rumah sakit dalam memberikan pelayanan kefarmasian kepada pasien. Dari September sampai November 2021, tujuan dari penelitian ini adalah untuk mengetahui kesesuaian obat peresepan pasien kronis di poliklinik jantung rawat jalan BPJS ke Formularium Nasional di RSU Astrini Wonogiri. Penelitian ini dilakukan sebagai survei deskriptif (noneksperimental). Cara pengambilan sampel dari suatu populasi dengan menggunakan sampling acak sistematik. Populasi penelitian ini termasuk 1567 pasien dengan total ukuran sampel 113 pasien dan 788 item obat dengan inklusi dan eksklusi kriteria. Menurut temuan penelitian, 742 item obat, atau 94,16% dari penulisan resep, berada sesuai Formularium Nasional, sedangkan 46 item obat atau 5,84% tidak. Kementerian Target kesehatan 100% belum tercapai. Semakin tinggi persentase resep yang sesuai dengan Formularium Nasional, semakin tinggi kualitas pelayanan yang diberikan oleh Instalasi Farmasi.
KESESUAIAN PROSES REKONSTITUSI ANTIBIOTIK INJEKSI DI BANGSAL ANAK RUMAH SAKIT UMUM (RSU) ASSALAM GEMOLONG SRAGEN
Authors: Anggrahini Mustika , Anggraini Truly Dian
Published: August 2024

Proses rekonstitusi adalah proses pencampuran medium pelarut kedalam masa serbuk kering hingga menghasilkan zat tersuspensi yang dilakukan secara aseptik. Penelitian ini bertujuan untuk mengetahui kesesuaian proses rekonstitusi antibiotik injeksi serbuk kering di bangsal anak RSU Assalam Gemolong. Penelitian ini merupakan penelitian deskriptif menggunakan teknik sampling jenuh dengan pengumpulan data pengamatan secara langsung menggunakan checklist selama satu bulan. Hasil penelitian menunjukkan persentase kesesuaian proses rekonstitusi antibiotik injeksi berdasarkan SPO & Panduan Pencampuran Obat RSU Assalam Gemolong yaitu pada kesesuaian perhitungan dosis, pemilihan jenis pelarut dan penyimpanan setelah di rekonstitusi (100%), kesesuaian pada perhitungan volume pelarut (62,63%), kesesuaian pada pembuatan label obat (76,77%), kesesuaian pada pencampuran obat secara aseptis (58,58%), serta kesesuaian pada pembuangan semua bekas pencampuran obat (88,89%). Sedangkan berdasarkan Pediatric Injectable Drug 10th edition & Handbook on Injectable Drugs 17th edition diperoleh hasil penelitian yaitu kesesuaian pada perhitungan dosis (90,91%), kesesuaian pada pemilihan jenis pelarut dan pada penyimpanan setelah direkonstitusi (100%), serta kesesuaian pada perhitungan volume pelarut (58,59%). Maka persentase kesesuaian proses rekonstitusi antibiotik injeksi berdasarkan SPO & Panduan Pencampuran Obat RSU AssalamGemolong yaitu 83,84% dari 7 aspek pengamatan, Sedangkan berdasarkan Pediatric Injectable Drug 10th edition & Handbook on Injectable Drugs 17th edition yaitu 87,37% dari 4 aspek pengamatan.
TINGKAT KEPATUHAN PENGGUNAAN MASKER PASIEN APOTEK KEPUTRAN SEBAGAI UPAYA PENCEGAHAN PENULARAN VIRUS COVID-19 DI MASA PANDEMI
Authors: Apriastuti Rohma , Adiningsih Retnowati
Published: August 2024

Dunia saat ini tengah waspada dengan penyebaran virus corona dan menjadi pandemi di seluruh dunia. Jumlah kasus covid-19 yang terus  meningkat menjadikan permasalahan yang serius. Hasil penelitian sebelumnya, 74,19% responden  patuh dalam penggunaan masker dan 25,81% responden tidak patuh dalam penggunaan masker. Tujuan penelitian untuk mengetahui tingkat kepatuhan pasien Apotek Keputran dalam menggunakan masker sebagai upaya pencegahan penyebaran virus covid-19. Penelitian ini merupakan penelitian deskriptif kuantitatif  dengan menggunakan metode purposive sampling, dimana responden dalam penelitian adalah pasien Apotek Keputran sebanyak 100 orang dengan menggunakan instrumen kuisioner tentang kepatuhan memakai masker. Hasil data yang diperoleh didapatkan responden laki-laki sebanyak 52 orang (52%) dan perempuan 48 orang (48%). Mayoritas responden (36%) berusia 15 – 30 tahun dan usia terendah 56 – 64 tahun (16%). Pendidikan responden paling banyak adalah tamatan SMA (36%) dengan pekerjaan tertinggi sebagai pegawai swasta (26%). Hasil penelitian menunjukkan kategori patuh sebanyak 68 orang (68%) dan tidak patuh sebanyak 32 orang (32%), dimana sebagian besar yang tidak patuh merupakan tamatan SD dan tergolong usia 56 – 64 tahun. Dari hasil penelitian, disimpulkan bahwa tingkat kepatuhan pasien Apotek Keputran dalam menggunakan masker yang baik dan tepat sebesar 68%.
GAMBARAN PENGETAHUAN MASYARAKAT TENTANG DAGUSIBU DI DUKUH POKO RT 02 RW 05 DESA DUWET WONOSARI KLATEN
Authors: Ningsih Yuliana Salma Eka , Sari Yunita Dian Permata , Putri Vania Santika
Published: August 2024

Drugs are used to cure the disease that is being suffered by the patient. However, theres people who not know the actual use drugs tht are good and right, so that errors in the use of drugs often occur. DAGUSIBU (Get, Use, Save, Discard) is a Drug Awareness Family Movement Program created by the Indonesian Pharmacist Association in achieving public understanding and awareness of the correct use of drugs (Indonesian Pharmacist Association, 2014). The purpose of this study was to determine the level of knowledge about DAGUSIBU as a self-medication effort among the people of Dukuh Poko RT 02 RW 05 Duwet Village, Wonosari, Klaten. This type of research is a non-experimental research with a descriptive survey design of the community in Dukuh Poko RT 02 RW 05 Duwet Village, Wonosari, Klaten. The number of samples used were 86 respondents and the data collection technique used the total sampling method. The data obtained is the percentage of each answer to the questionnaire that has been filled in by the respondent. Based on the results of data processing, it was obtained that the level of public knowledge was in the good category, 57 (66%), 23 (27%) had sufficient knowledge, and 6 (7%) lacked knowledge. So it can be concluded that the average level of knowledge about DAGUSIBU medicine in the Dukuh Poko RT 02 RW 05 community has a good level of knowledge (80%).
PENGARUH VARIASI CARBOPOL DAN CMC-NA SEBAGAI GELLING AGENT TERHADAP FORMULASI DAN EVALUASI SEDIAAN GEL LENDIR BEKICOT (Achatina Fulica)
Authors: Subekti Istiara
Published: August 2024

Bekicot (Achatina fulica) mengandung achasin yang dapat digunakan sebagai anti jerawat. Untuk memudahkan penggunaannya dibuat dalam bentuk sediaan gel. Penelitian ini bertujuan untuk mengetahui formulasi dan evaluasi gel lendir bekicot (Achatina Fulica) dengan variasi konsentrasi karbopol dan pembentuk gel CMC-Na. sebagai pembentuk gel terhadap sifat fisik sediaan gel lendir bekicot (Achatina Fulica). Metode penelitian yang digunakan adalah metode eksperimen. Sediaan gel dibuat menggunakan bahan aktif lendir bekicot (Achatina Fulica) dengan berbagai konsentrasi gelling agent karbopol 1%, karbopol: CMC-Na 0,5%: 0,5%, dan CMC-Na 1%. Hasil uji organoleptik sediaan gel F1 berwarna putih, F2 berwarna putih pekat, F3 bening. Uji homogenitas menunjukkan sediaan homogen, uji pH sediaan gel F1= 3,86±0,030; F2= 4,87±0,15; F3= 6,90±0,08, F1 dan F2 tidak memenuhi syarat pH kulit 4,5-6,5. Uji adhesi F1= 1,03±0,01 detik; F2= 1,13±0,015 detik; F3= 1,07±0,01 tidak sesuai dengan parameter persyaratan uji adhesi. Uji daya sebar F1= 5,41±0,28; F2= 4,75±0,25; dan F3= 1,07±0,01. F3 memenuhi syarat uji daya sebar yaitu 5-7cm, uji viskositas F= 13070 ±116; F2= 35889±163; F3= 3530±133. F1 dan F2 memenuhi persyaratan viskositas yaitu 2000-4000 cps. Hasil uji hedonik yang paling disukai panelis adalah F3. Berdasarkan hasil SPSS menggunakan metode One Way Anova dan kruskall-wallis dapat dikatakan bahwa variasi gelling agent karbopol dan CMC-Na berpengaruh signifikan terhadap hasil evaluasi fisik daya sebar, namun tidak berpengaruh signifikan terhadap viskositas, adhesi, dan pH.