bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Pengelolaan Kawasan Ekowisata Mangrove Berkelanjutan Di Taman Wisata Alam Teluk Yotefa Kota Jayapura.
Authors: Rumahorbo Basa T.
Published: July 2023

The concept of environmental management based on sustainability ecotourism is starting to be seen as important given the large amount of environmental damage. Until now the mangrove forest in Yotefa Jayapura Bay Nature Park has not been managed properly as an ecotourism destination, therefore a Mangrove Ecotourism Area Management Strategy is needed in Yotefa Jayapura Bay Nature Park. This study aims to analyze the management strategy for the mangrove ecotourism area in Hamadi Beach, Kota Jayapura using a qualitative approach with descriptive analysis and SWOT analysis. The results of the study show that based on observations through surveys, it is known that Mangrove forests, especially around the Yotefa Bay Nature Park, Jayapura. There are 4 strategies in managing the mangrove ecotourism area management strategy at Hamadi Beach, Jayapura City, namely: 1. Development of community-based ecotourism with support government through related agencies, 2. Providing comfortable and safe facilities and infrastructure and improving the arrangement of facilities that are lacking, 3. Increasing community participation in various activities related to mangrove forests and tourism, 4. Outreach to ecotourism activities for the community.
Analisis Perubahan Garis Pantai Menggunakan Digital Shoreline Analysis System: Studi Kasus Wilayah Pesisir Kota Jayapura, Provinsi Papua
Authors: Hamuna Baigo , Kalor John Dominggus
Published: July 2023

Study of shoreline change is an important step in understanding the dynamics in the coastal area in Jayapura City and is a first step to reduce the risk of coastal erosion and also minimize social, physical and economic losses. This research was conducted in the coastal area of Yos Sudarso Bay, Jayapura City, Papua Province by utilizing multi-temporal Landsat satellite imagery (Landsat 5 TM, Landsat 7 ETM+ and Landsat 8 OLI-TIRS) for 1994, 2000, 2007, 2014 and 2020. Analysis Shoreline changes are determined using the Digital Shoreline Analysis System (DSAS). End Point Rate (EPR), Net Shoreline Movement (NSM) and Linear Regression Rate (LRR) are used to calculate the rate of change of the coastline and predictions of change of the coastline for the next 10 years. The results showed that in the period 1994-2000 there was an area of 535749.22 m2 of abrasion and 399361.87 m2 of accretion. During the 2000-2007 period, 453,876.10 m2 of abrasion occurred and 447,121.39 m2 of accretion. In the 2007-2014 period there was 781,274.83 m2 of abrasion and 259,221.26 m2 of accretion. In the 20014-2020 period, 93,328.79 m2 of abrasion occurred and 74,204.42 m2 of accretion. Spatially, the coastal areas of Yos Sudarso Bay, Jayapura City, which experienced abrasion included Holtekamp Beach, Hamadi Beach, and a small part in Youtefa Bay, while those that experienced accretion included DOK II Beach, Entrop Beach, Ciberi Beach, in Youtefa Bay and Cape Ria. The shoreline changes rate (LRR) in the coastal area of Yos Sudarso Bay, Jayapura City due to abrasion in the period 1994 to 2020 is 0.89 m/year, while the shoreline change rate due to accretion is 0.70 m/year. Based on the prediction of shoreline changes at Holtekamp Beach, it is predicted that the highest abrasion will occur as far as 50.19 m with an average abrasion distance of 20.22 m, while the highest accretion is as far as 19.19 m with an average accretion distance of 10.55 m.
Perbandingan Stok Karbon Mangrove Rhizophora mucronata di Kampung Enggros dan Entrop, Jayapura, Papua.
Authors: Hisyam Muhammad , Indrayani Ervina , Kalor John D , Waum Ida
Published: July 2023

Mangrove ecosystems have an important role as a filter for CO2 gas that is in the air through the process of photosynthesis. This is why the existence of mangrove forests is of great concern in maintaining the carbon cycle in the world. Most of the mangrove forests in Indonesia are in the Papua region, which accounts for one-third of the total area of mangrove forests in Indonesia. One of the mangrove forest areas that is quite thick is in the Youtefa Bay area in Enggros and Entrop Villages with Rhizophora mucronata species found. This research was conducted by measuring the carbon content using an allometric formula that utilizes stem diameter values. This study showed that the biomass of Rhizophora mucronata in Entrop Village was more than that of Enggros Village, which was 1063.44 Kg. Carbon content and absorption also showed results that were directly proportional to the biomass in Entrop Village at 19.4616 and 71.42 Kg/m2. The ratio of the difference in biomass and carbon content between the two villages also shows a difference of 14%.
Pola Distribusi Spasial Dan Temporal Spesies Lebtobrama Sp. Dengan Menggunakan Teknologi Citra Satelit Aqua Modis Di Perairan Distrik Naukenjerai Kabupaten Merauke.
Authors: Welliken Marius Agustinus , Melmambessy Edy H.P
Published: July 2023

This study aims to determine the spatial and temporal variations of chlorophyll-a and SST by using fashionable satellite data in Naukenjerai District waters and the correlation of chlorophyll-a and SST to the distribution of species Lebtobrama Sp. in the Naukenjerai District. This research was conducted in May to June 2022 in the waters of the Naukenjerai District. MODIS image data analysis was performed at the Aquatic Resources Management Laboratory. The data used are data on the catch and the coordinates of the catch from May to June 2022. The results of this study indicate that the distribution of species Lebtobrama Sp. catches from May to June was 857 kg for 12 trips. While the range of chlorophyll-a in May to June ranged from 0.3 mg /m³ - 2.28 mg/m³ and the SPL range from May to June ranged between 25.42°C - 28.42°C. The results of the correlation between chlorophyll-a and species Lebtobrama Sp. catches showed a moderate relationship (correlation coefficient (r) 0.48), while the relationship between SPL and species Lebtobrama Sp. catches showed a strong relationship (correlation coefficient (r) 0.58) and the relationship of chlorophyll-a and SPL with the trapped catch shows a strong relationship (correlation coefficient (r) 0.59).
PROSPEK USAHA SAMPAH PLASTIK PADA RT 05 AIR SAKULA DESA LAHA KECAMATAN TELUK AMBON
Authors: Melmabessy Simson
Published: July 2023

Letak Kota Ambon berada sebagian besar dalam wilayah pulau Ambon, dan secara geografis terletak pada posisi: 3 -4 Lintang Selatan dan 128 -129 Bujur Timur, dimana secara keseluruhan Kota Ambon berbatasan dengan Kabupaten Maluku Tengah. Sesuai Peraturan Pemerintah Nomor 13 Tahun 1979 luas wilayah Kota Ambon seluruhnya 377 Km2 dan berdasarkan hasil Survey Tata Guna Tanah tahun 1980 luas daratan Kota Ambon tercatat 359,45 km2. Sesuai Perda Kota Ambon Nomor 2 Tahun 2006, Kota Ambon memiliki lima kecamatan dengan luas masing-masing: Kecamatan Nusaniwe 8.834,30 Ha, Kecamatan Sirimau 8.681,32 Ha, Kecamatan Teluk Ambon 9.368,00 Ha, Kecamatan Teluk Ambon Baguala 4.011,00 Ha dan Kecamatan Leitimur Selatan dengan luas 5.050 Ha.Adapun luas Kecamatan Teluk Ambon 9.368,00Ha yang berpotensi menghasilkan sampah yang sangat besar yang dihasilkan oleh idustri rumah tangga,kios/tempat usaha, pedagang, Bandara Pattimura dan Pertamina, ditambah dengan lasehan dan industry-industri lainnya. Hal ini akan menjadi peluang usaha bagi masyarakat yang berdomisili dekat dengan lokasi tersebut.Sampah seringkali dikaitkan dengan sesuatu yang kotor, kumuh dan sangat menjijikan. Namun siapa sangka jika sampah yang tak berguna tersebut dapat dimanfaatkan menjadi suatu benda yang bernilai tinggi. Sampah yang berada di lingkungan masyarakat mulanya akan dibuang ke tempat pembuangan sampah sementara atau yang biasa disebut TPS, kemudian akan diangkut kembali ke TPA (Tempat Pembuangan Akhir) untuk dikelola kembali oleh Dinas lingkungan hidup dan persampahan Kota Ambon. Namun tidak semua sampah dapat terangkut, dan inilah masalah yang sering terjadi pada sampah.Pengelolaan sampah yang dilakukan masyarakat umumnya hanya memberikan dampak negatif, yaitu dilakukan dengan membakar sehingga menyebabkan polusi udara, ditimbun menjadi polusi tanah, dan dibuang kesungai atau laut menyebabkan polusi air, sehingga pengolahan sampah  harusnya dapat menggunakan cara yang berbeda.Pengelolaan sampah plastik dapat dijadikan berbagai produk yang mempunyai nilai ekonomi yang tinggi.
SEARCHING FOR A FAIR ALLOCATION OF SCARCE MEDICAL RESOURCES UNDER EU LAW: A NEED FOR BALANCE FOR THE ELDERLY?
Authors: KAYA Gözde
Published: July 2023

Fair allocation of scarce medical resources during emergency situations such as the COVID-19 pandemic is a highly challenging task. The pandemic has revealed that age was invoked as a criterion in terms of granting access to medical treatment in some European Union countries such as Italy. This paper analyses whether or not the use of chronological age alone might be justified for any such differential treatment in the event of scarcity. The paper seeks to demonstrate that older persons should not be automatically excluded from receiving access to healthcare which might otherwise amount to direct discrimination under European Union law.
BREXİT KARARINI MEŞRULAŞTIRMA ARACI OLARAK TÜRKİYE’NİN AVRUPA BİRLİĞİ ÜYELİĞİ: AYRILMA YANLISI AKTÖRLERİN SÖYLEMLERİNİN ANALİZİ
Authors: KOÇER Gökhan , SEPLİ Ayçe
Published: July 2023

Bu çalışma, Birleşik Krallık’ta Avrupa Birliği (AB) referandumuna giden süreçte yürütülen ayrılma kampanyasını incelemekte ve referandum tartışmalarını şekillendiren ayrılma yanlısı aktörler olarak ön plana çıkan Vote Leave (VL) ve Birleşik Krallık Bağımsızlık Partisi’nin (UKIP) yürüttüğü kampanyaya odaklanmaktadır. Çalışmanın örneklemini, Türkiye’nin AB üyeliğine ilişkin olarak gerçekleşen tartışmalar oluşturmaktadır. Çalışmada temel amaç, ayrılma yanlısı aktörlerin Türkiye’nin üyeliği hakkında ürettikleri Avrupa şüpheci söylemler aracılığıyla inşa etmeye çalıştıkları AB temsillerini ortaya koyarak, Brexit kararını nasıl meşrulaştırmaya çalıştıklarını açıklığa kavuşturmaktır. Çalışmada, araştırma metodu olarak söylemsel-tarihsel yaklaşım benimsenmiştir. Çalışmanın bulgularına göre, ayrılma yanlısı söylemlerde, Türkiye’nin olası üyeliği araçsallaştırılarak, AB ve Birleşik Krallık’ın AB üyelinin devam etmesi durumu sorunsallaştırılmıştır. Bu da, Avrupa şüpheciliğinin söylemsel olarak yeniden üretilmesini sağlayarak Brexit yönünde verilen oylara zemin hazırlama işlevi görmüştür.
Європейські орієнтири розвитку України в умовах війни та глобальних викликів ХХІ століття: синергія наукових, освітніх та технологічних рішень. Том 1.
Authors:   Національний університет ", Ківалов Сергій Васильович ,   Одеська юридична академія"
Published: July 2023

Матеріали Міжнародної науково-практичної конференції «Європейські орієнтири розвитку України в умовах війни та глобальних викликів ХХІ століття: синергія наукових, освітніх та технологічних рішень». У першому томі збірника містяться наукові напрацювання вчених, практиків, військовослужбовців у теоретичній та емпіричній площині в умовах повномасштабного військового вторгнення у сферах філософських основ, загальної теорії та історичних досліджень держави і права, актуальних проблем світових соціально-політичних процесів, соціології та психології. Висвітлено питання загроз національній безпеці в їхньому конституційному вимірі, у рамках міжнародного та європейського права, трудового права та права соціального забезпечення, земельного, аграрного та екологічного права, пов’язані з функціонуванням економіки та підприємництва в умовах європейського вибору України. Розглянуто проблеми інформатизації та цифровізації суспільства, захисту інформації та кібербезпеки в умовах військового вторгнення, питання методики викладання іноземних мов, теорії та практики перекладу, проблеми лінгвістики та журналістики. Збірник розраховано на наукових та науково-педагогічних працівників, здобувачів вищої освіти, практичних працівників у сферах юридичної, економічної, соціологічної, політологічної, психологічної, філологічної наук, журналістики та кібербезпеки тощо.
OPPORTUNITIES FOR OBTAINING ADDITIONAL YIELD FROM SUCKERS OF THE VINE VARIETIES DUNAV AND PANSE PRÉCOCE
Authors:   Agricultural University, Plovdiv, Bulgaria, Keranova N. , Emurlova F. ,   Trakia University, Stara Zagora, Bulgaria, Roychev V. ,   Agricultural University, Plovdiv, Bulgaria, Ivanov A. ,   Trakia University, Stara Zagora, Bulgaria
Published: July 2023

The possibilities of obtaining an additional grape yield from suckers in early ripening seed table varieties Dunav and Panse Précoce were studied. It was found that, under the soil and climatic conditions of the experiment, the vines of these varieties annually form suckers on their main shoots, from which an additional grape yield can be obtained by the end of the growing season. In the case of Dunav, this yield was 25.30 % and in the case of Panse Précoce − 32.44 % of the yield of the main shoots. In both varieties, there is a mathematically proven very strong positive correlation between most of the studied ampelographic parameters recorded in the main shoots and their suckers. The most frequently observed increase in their values in the main shoots leads to the same in the suckers. The analytical representation of these relationships by regression models proves their direction.
EFFECT OF BOTTLE AGING ON COMPOSITION OF ORGANIC ACIDS IN WHITE WINES FROM GRAPEVINE VARIETIES OF HUNGARIAN BREEDING GROWN IN THE LOWER DON REGION
Authors:   All-Russian Research Ya.I. Potapenko Institute for Viticulture and Winemaking – Branch of the Federal State Budget Scientific Institution «Federal Rostov Agricultural Research Center», Novocherkassk, Russia,, Kalmykova N.N. , Kalmykova E.N. ,   All-Russian Research Ya.I. Potapenko Institute for Viticulture and Winemaking – Branch of the Federal State Budget Scientific Institution «Federal Rostov Agricultural Research Center», Novocherkassk, Russia,, Gaponova T.V. ,   All-Russian Research Ya.I. Potapenko Institute for Viticulture and Winemaking – Branch of the Federal State Budget Scientific Institution «Federal Rostov Agricultural Research Center», Novocherkassk, Russia,
Published: July 2023

The aim of the work was to study the influence of bottle aging on the composition of organic acids and organoleptic properties of wines made from white grapevine varieties of Hungarian breeding growing in the Lower Don Region. The objects of the study were dry white wines made from grapevine varieties of Hungarian breeding − Bianca, Lakhedyi mesesh, Crystal, control − Aligote (Vitis vinifera L.), aged in a bottle from 1 to 3 years in the oenoteca of the Institute. The studies showed that during 3 years of aging the total content of organic acids (sum) decreased by 0.35−2.41 g/dm3. The largest decrease in the amount of organic acids was noted in the experimental wines from the variety Bianca (by 2.41 g/dm3). In the experimental wines the total amount of tartaric and malic acids was 56,8−76,3% of all the acids in the wine and decreased in the wines from variety Aligote (control) − by 11.2 %; Bianca − by 18.6 %; Lakhedi Mezesh − by 10,2 %; Kristall − by 7 % as it was aged in the bottle. The greatest decrease in tartaric acid concentration was observed in experimental wines of Bianca variety (by 2.4 g/dm3). In all the experiments the concentrations of succinic acid (by 13.3−28.3 %) and citric acid (by 20−38 %) decreased. The change of succinic acid content in the wines from Aligote variety (control) occurred after 2 years of aging in bottle, and of citric acid after 3 years of aging. In wines from varieties of Hungarian breeding (Bianca, Lakhedy Mesz, Crystal) it was observed that the change of citric acid content occurred after 2 years of aging and of amber acid content after 3 years. As a result of the organoleptic analysis it was determined that the highest tasting scores were given to Aligote (Control) (8,7−8,9 points) and Lakheddi mezesz (8,6−8,7 points), these wines during 3 years long aging had a bright varietal aroma, and more over their bouquet has improved, they have a light harmonious taste with a long pleasant aftertaste.
Extra-Thoracic Subclavian Vein Access: The Tips And Tricks
Authors:   University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria, Edafe Emmanuel Auchi , Dodiyi-Manuel Sotonye T ,   University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
Published: July 2023

The success of any trans-venous procedure involves the rate liming step, which is the access. The procedure cannot be performed without the access site. It is the key that open the success of the procedure. There are many procedures that require extra-thoracic subclavian vein. These procedures may include: central venous pressure monitoring, administration of multiple medications and drips, high volume/flow resuscitation, emergency venous access, inability to obtain peripheral venous access, repetitive blood sampling, administering hyperalimentation, vasopressors, caustic agents, or other concentrated fluids; insertion of transvenous cardiac pacemakers, hemodialysis or plasmapheresis and insertion of pulmonary artery catheters. In this review, we discuss the various techniques of accessing the vein and it tips and tricks..
A Case of Idiopathic Intracranial Hypertension in Association with Central Venous Sinus Thrombosis in Post-Partum Woman
Authors:   Anesthetic Registrar, Department of Anesthesia, Critical Care and Pain Medicine, Beaumont Hospital, Dublin, Ireland, Qutishat Fadi , Lal Shankar ,   Anesthetic and ICU fellow, Department of Anesthesia, Critical Care and Pain Medicine, Beaumont Hospital, Dublin, Ireland, Murphy Stephen ,   ICU fellow, Department of Anesthesia, Critical Care and Pain Medicine, Beaumont Hospital, Dublin , Ireland, Masoud Mustafa ,   ICU fellow, Department of Anesthesia, Critical Care and Pain Medicine, Beaumont Hospital, Dublin , Ireland, Power Michael ,   Anesthetesia and ICU Consultant, Department of Anesthesia, Critical Care and Pain Medicine, Beaumont Hospital, Dublin, Ireland
Published: July 2023

This case report discusses a rare case of idiopathic intracranial hypertension (IIH) in association with central venous sinus thrombosis (CVST) in a post-partum woman. The patient fortunately recovered from this rare disorder and was discharged well after about 3 weeks of hospital stay. In this paper, we will describe various stages of her condition, the factors or causes that may be responsible, the diagnosis and treatment provided to the patient, and the effects of a multispecialty approach on the patient's outcomes.
Differential expression of heat shock proteins in cutaneous squamous cell carcinoma
Authors:   Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China, Yu-Xin Jiang , Jing Xu ,   Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China, Ang Li ,   Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China, Wang Ping ,   Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China, Ai-Jun Chen ,   Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
Published: July 2023

Cutaneous squamous cell carcinoma (CSCC) is a malignant tumor originating from keratinocytes in the epidermis, which seriously affects people's life safety. Heat shock proteins (HSPs) are molecular chaperones that help maintain protein stability and are involved in tumor activities. However, there is currently no systematic study of HSPs in CSCC. In this study, we used qPCR and WB to explore the expression of 14 HSPs at mRNA and protein levels in human immortalized keratinocytes HACAT cells, human CSCC cell lines COLO-16 and SCL-1 cells, and collected human CSCC samples for histological verification. Eventually, we found that the expression levels of different HSPs in CSCC were different. HSPB6, HSPB8 and HSPB11 showed no dysregulation in CSCC. HSPB4, HSPB5, HSPB7, HSPB10 and HSP40 were significantly upregulated in CSCC cells, while HSPB1, HSPB9, HSP60, HSP70, HSP90 and HSP100 were significantly downregulated. In summary, we validated the expression of 14 common HSPs in CSCC, which may lay the foundation for the study of HSPs in CSCC.
Syphylitical Myelopathies: Study of 8 observations at National Hospital Ignace Deen, University of Conakry
Authors:   Neurology Department, Ignace Deen Conakry University Hospital, Conakry University Hospital, ML Touré , Othon G Carlos , TH Baldé , SM Diallo , BKJB, Ballo , Djibo Hamani AB , Sakadi F , Sakho A , Kassa DF , Cissé FA , Cissé A
Published: July 2023

Introduction: Myelopathies occurring in the context of neurosyphilis have been poorly studied clinically, radiologically and in tropical settings. The diagnostic certainty of the syphilitic etiology of myelopathy is difficult to establish because of the multiplicity of causes of spinal cord damage. Patients and Methods: We carried out a retrospective study of 269 patients hospitalized for spinal cord disorders between January 2015 and December 2021, among whom 8 (eight) patients were identified for progressive syphilitic myelopathy diagnosed by the positivity of VDRL-TPHA serological reactions in the blood and cerebrospinal fluid and radiological data. Magnetic resonance imaging was performed in all patients. Results: The neurological signs were limited to the existence of a sensory-motor spinal semiology in particular, paraparesis with sphincter disorders, especially moderate urinary disorders, without an obvious infectious syndrome in a context of positive serological reactions VDRL-TPHA in the blood and cerebrovascular fluid. spinal. Lumbar puncture shows hypercellularity with lymphocyte predominance on average 65% and hyperproteinorachia varying from 0.98 to 1.36 g/l. magnetic resonance imaging performed in all patients contributed to the diagnosis by showing hypersignals in T2, expression of more or less extensive lesions on several segments.
Ischemic Cerebrovascular Accidents in HIV Patients on Antiretroviral Therapy: Clinical, Paraclinical And Prognostic Aspects in The Neurology Department of The University Hospital Center of Conakry
Authors:   Neurology Department, Ignace Deen National Hospital in Conakry, Souleymane Djigue Barry , Wenceslas Sossa Doré Malé ,   Neurology Department, Ignace Deen National Hospital in Conakry, Karinka Diawara ,   Neurology Department, Ignace Deen National Hospital in Conakry, Mohamed Lamine Condé ,   Neurology Department, Ignace Deen National Hospital in Conakry, Lamine Touré Mohamed ,   Neurology Department, Ignace Deen National Hospital in Conakry, Victor Bognon ,   Neurology Department, Ignace Deen National Hospital in Conakry, Cissé Fodé Abass ,   Neurology Department, Ignace Deen National Hospital in Conakry
Published: July 2023

Introduction: Ischemic stroke (Stroke) constitute, due to the demographic and epidemiological transition, a real challenge for developing countries and HIV infection, a real public health problem in these countries. The objective of our study was to describe aspects of clinical, paraclinical and prognostic ischemic stroke in people living with HIV (PLHIV) on antiretrovirals (ARVs). Material and methods: This was a prospective study of the descriptive type lasting 6 months from January 1, 2022 to June 31, 2022, relating to ischemic cerebrovascular accidents (DALYs) in HIV patients on ARVs.Were included patients admitted or hospitalized in the service for seropositive ischemic stroke under ARV for an average duration of 35.5 months. Patients recently put on ARVs and those with an obvious cause of DALY such as (diabetes, uncontrolled hypertension, emboligenic heart disease) were excluded. Results: During our study period, 336(94%) patients were listed. Among them, 20 have ischemic stroke associated with HIV on ARVs, i.e. 6%. This study showed that the average age of onset of ischemic stroke in PLHIV on ARV was 49 ± 11.6 years with a sex ratio F/M of 1.22. The risk factors were high blood pressure 13 (65%), diabetes 05 (25%), followed by alcohol 04 (20%). HIV type 1 was represented at 100%, then 16 (80%) of our patients were at WHO stage III with a CD4 count between 200 and 300 cells/µl09 (45%). The therapeutic line of ARVs was dominated by TDF+3TC+EFV at 14 (70%) followed by AZT+3TC+LPV/r at 04 (20%) and the average duration of patients on ARV was 35.5 months. The favorable evolution was marked 13 (65%), followed by a death in (10%) or 02. The location on the cerebral scanner was dominated by the sylvian artery in 12 (60%) of cases followed by the anterior cerebral artery (ACA) 06 (30%) and the posterior cerebral artery ( PCA) 02 (10%). Conclusion: Ischemic stroke in HIV patients on ARVs requires early management and regular monitoring
Disseminated Intravascular Coagulation Associated With SARS-COV-2 Infection: A Post- Mortem Case Study
Authors:   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, da Silva Cláudio Gleidiston Lima , dos Santos Maria do Socorro Vieira ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, Machado Sávio Samuel Feitosa ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, Barreto Tiburi Rosa Gabryella ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, Pinheiro Jucá Marina Catunda ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, Lima Barros Luana ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, de Carvalho Ana Flávia Moreira ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, Novais Lima Bruna Raynara ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, de Souza Bezerra, João Pedro ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil, Leite Rolim Neto Modesto ,   School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil
Published: July 2023

The mechanisms of coagulation disorder in COVID-19 are complex. However, it is already postulated that endotheliopathy and platelet activation may be important factors, causing direct damage to endothelial cells and the imbalance of inflammatory response, manifesting by venous arterial or microvascular thrombosis. The present study aims to describe a clinical case of an 8-year-old female patient with disseminated intravascular coagulation due to sepsis of viral etiology.
Genital Manifestations of Monkeypox Infection: Two Case Reports
Authors:   Department of Urology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil, de Souza Vale Ana Luiza Muniz , de Lima Junior Carlos Alberto ,   Department of Urology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil, Pereira-Correia João Antonio ,   Department of Urology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil, Fernandes Muller Valter José ,   Department of Urology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil
Published: July 2023

We present two cases of HIV-positive male patients, with a confirmed diagnosis of monkeypox through molecular diagnosis, with genital involvement.
The Mini Review of The Impacts of Long COVID-19 on Multi-System
Authors:   Shanghai University of Medicine and Health Sciences, Shanghai, China, Yao Xinyuan , Xu Qi ,   Shanghai University of Medicine and Health Sciences, Shanghai, China, Ye Weidong ,   Shanghai University of Medicine and Health Sciences, Shanghai, China, Chen Shuyi ,   Shanghai University of Medicine and Health Sciences, Shanghai, China, Li Shuang ,   Shanghai University of Medicine and Health Sciences, Shanghai, China
Published: July 2023

COVID-19 is a highly contagious respiratory illness caused by the novel coronavirus SARS-CoV-2. Symptoms of COVID-19 can range from mild to severe and include fever, cough, and difficulty breathing. As research deepens, more and more data indicate that the number of patients continue to experience symptoms of COVID-19 long after they have recovered from the initial illness. We summarized the long COVID-19 symptoms in an integrated way and found that the symptoms of each system are correlated to some extent, suggesting that a multi-system evaluation is necessary when treating COVID-19, rather than merely focusing on treating individual systems. As the novel coronavirus is a new virus and the human immune system's response mechanisms are not yet fully understood, the impact of long COVID-19 may last for a significant period of time. This review may help clinical practitioners gain a comprehensive understanding of long COVID-19 to alleviate patients’ affection
Successful Treatment of Severe Lead Poisoning Children with Low Dosage of CaNa2EDTA -A Retrospective Study of 8 Cases from China
Authors:   Department of pediatrics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China, Li Peng , Huang Shuxia ,   Department of pediatrics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China
Published: July 2023

Background: To analyze the clinical features, treatment and prognosis of 8 Chinese children with severe lead poisoning. Methods: 8 children with blood lead levels (BLLs) over 45ug/dL hospitalized at Beijing Chaoyang Hospital of Capital Medical University from January 2015 to December 2019 were diagnosed as severe lead poisoning. Detailed medical data were retrospectively studied. All patients accepted the chelation therapy with calcium disodium ethyleneaminetetraacetate (CaNa2 EDTA). Results: The onset age ranged from 3 months to 12 years old. BLLs ranged from 46.6ug/dL to 120.2ug/dL. The sources of lead exposure were different while 3 cases had taken Chinese herbs. 3 cases had symptoms of nervous system. 3 cases had anemia. 2 cases had abnormal liver function. All patients had normal renal function. All cases accepted the repeated treatment of consecutive intravenous CaNa2 EDTA (20mg/kg/d, 5 days every month), until BLLs remained below 40ug/dL. 1 case One case got rash and one patient got transient elevated serum transaminase during the courses. All cases had BLLs under 45ug/dL on followup. Conclusion: Chinese herbs containing lead might be one of the attributing factors of lead poisoning in children. Low dosage of CaNa2 EDTA was relatively safe and effective in dealing with lead poisoning in children.
Determinants of Neonatal Morbidity And Mortality In The Suburbs of Dakar in Senegal
Authors:   Department of Pediatrics, National Hospital Center of Pikine, Dakar/Senegal, Ly F , Ndiaye D , Sakho Kane A , Sarr FN
Published: July 2023

Introduction: Neonatal morbidity and mortality is a major public health problem in developing countries such as Senegal. The objective of our study was to study the determinants of neonatal morbidity and mortality in a hospital located in the suburbs of Dakar in Senegal. Materials and methods: We conducted a retrospective, descriptive and analytical study over the period from 1 January to 31 December 2019 (1 year). Results: Of the 1198 children hospitalized in the ward, all 500 were newborns. (incidence=41.7%). The sex ratio was 1.29. The most common maternal pathologies were hypertension, preeclampsia and diabetes. The notion of urogenital infection was reported in 21% of cases MPR was greater than 12 hours in 60% of cases. More than a quarter (27%) of newborns had not screamed at birth and 74% were resuscitated. Almost half of newborns (43%) were preterm infants. Hypotrophs accounted for 48% (n=202). Diagnoses on admission were dominated by infections neonatal, inhalation of amniotic fluid, hyaline membrane disease and perinatal asphyxia. The mortality rate was 19% (n=95). The most frequently found causes of death were related to prematurity (48.4%), respiratory distress (82%) and nosocomial infections (20%). Conclusion: Despite initiatives undertaken at the national level, statistics remain alarming and call for more efforts to be made to achieve the Sustainable Development Goals (SDGs) by 2030.
Infectious Complications After A Liver Transplant
Authors:   Director of Agrinio ICU, Thessaloniki, Greece, Michailidou Evangelia Michail , Katsanos Georgios ,   Assistant Professor of Surgery, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece, Antoniadis Nikolaos ,   Assistant Professor of Surgery, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece, Argiriadou Eleni ,   Associate Professor of Anaesthesiology – Cardioanaesthesiology, Department of Anesthesiology and Intensive Care, Aristotle University of Thessaloniki, Greece
Published: July 2023

Liver transplantation is a life-extending procedure for patients with end-stage liver disease (ESLD), post-transplant infections continue to be a leading cause of morbidity and mortality. Infection risk varies over time, with issues most commonly related to transplant surgery and nosocomial infections in the early post-transplant period. Because of the increased burden of immunosuppression, opportunistic infections become more common between 1 and 12 months post-transplant. As immunosuppression is reduced after 12 months, the risk of opportunistic infections decreases. Recipients are still vulnerable to community-acquired infections, and recurrent cholangitis may become an issue in those with chronic allograft dysfunction or recurrent cholestatic liver disease. This article will go over a strategy for dealing with infectious complications in the early, intermediate, and late stages following liver transplantation, with a focus on the most common infections as well as those of emerging concern
A Unified Primary Care Approach for the Management of Insomnia and Confusion Using the Clinical Pathway
Authors:   Department of Pharmacy, Nagoya Memorial Hospital, Japan, Kabeya Megumi , Yuasa Shu ,   Department of Pharmacy, Nagoya Memorial Hospital, Japan, Tokoro Chiaki ,   Nursing Department, Nagoya Memorial Hospital, Japan, Kubota Yosuke ,   Division of Psycho-oncology and Palliative Care, Nagoya City University Hospital, Japan, Tanaka Yoshiteru ,   Department of Pharmacy, Shinseikai Dai-ichi Hospital, Japan, Ina Kenji ,   Department of Geriatric Medicine, Shinseikai Dai-ichi Hospital, Japan, Kayukawa Satoshi ,   Department of Hematology, Nagoya Memorial Hospital, Japan.
Published: July 2023

Background: Delirium and confusion are risk factors for falls and its related injuries. Therefore, we designed a unified clinical pathway to reduce the risk of delirium among hospitalized patients. Methods: A unified approach of pharmacotherapy for managing insomnia and confusion, which is subdivided based on the patients’ age (<70 versus ≥70 years) and presence of diabetes mellitus, was implemented in Nagoya Memorial Hospital, Japan. Risk factors for delirium were assessed via a multidisciplinary approach. For older high-risk patients, suvorexant or trazodone was prophylactically prescribed to promote sleep. If delirium occurred, either quetiapine or perospirone was administered prior to the usage of risperidone or haloperidol. The amounts of prescribed sleep inducers and antipsychotic agents were examined. The application rate of the clinical pathway and incidence of falls were compared before and after its introduction. Results: The application of a unified approach for the management of insomnia and confusion significantly decreased the prescribed amounts of benzodiazepines and may be associated with the reduced incidence of falls among hospitalized patients. Conclusions: A clinical pathway assisted the selection of sleep inducers and antipsychotic agents. This is useful for managing inpatients safely by preventing delirium and subsequent falls.
Multicenter Randomized Controlled (Comparative) Open Prospective Study to Evaluate The Efficacy of The R-DA-EPOCH-21 And R-mNHL-BFM-90 ± Autologous Hematopoietic Stem Cell Transplantation Programs in Untreated Patients With De Novo Diffuse B-Cell Large Cell Lymphoma With Signs of Poor Prognosis - DLBCL-2015 Protocol
Authors:   National Medical Research Center for Hematology, Moscow, Russian Federation (Russia), Magomedova Aminat , Kravchenko Sergey , Misyurina Anna , Mangasarova Yana , Margolin Oleg , Fastova Ekaterina , Babaeva Fatima , Gorenkova Lilia , Bagova Madina , Nesterova Ekaterina , Sychevskaya Ksenia , Moiseeva Tatyana , Kovrigina Alla , Obukhova atyana , Dvirnyk Valentina , Maryina Salia , Galtseva Irina , Galuzyak Vladimir , Danishyan Karen , Kostina Irina , Gitis Mikhail , Sudarikov Andrey , Nikulina Elena , Biderman Bella , Klyasova Galina , Galstyan Gennady , Spirin Mikhail , Kulikov Sergey , Chabaeva Yulia , Zinina Elena , Kryuchkova Irina , Sizikova Svetlana , Sergeyevicheva Vera , Ksenzova Tatyana , Anikina, katerina , Shelekhova Tatyana , Arzhanukhina Olga , Kaplanov Kamil , Konstantinova atyana , Serdyuk Olga , Sychyova Tatyana , Chagorova Tatyana , hunayeva Irina Nec , Anchukova Lyudmila , Dzarasova Oksana , Savchenko Valery , Parovichnikova Elena
Published: July 2023

Background: NHL-BFM-90 chemotherapy is highly effective in pediatric aggressive B-cell lymphomas. Purpose: To evaluate the efficacy and toxicity of the R-mNHL-BFM-90 and R-DAEPOCH-21 programs in adult patients with de novo DLBCL. Patients and methods: Inclusion criteria: newly diagnosed DLBCL (NOS), no previous chemotherapy, 2 or more signs of poor prognosis, age 18-60. The protocol included 140 patients from 13 medical centers in Russia: R-DA-EPOCH-21 – 33; R-DAEPOCH-21+auto-HSCT - 29; R-mNHL-BFM-90 - 33; R-mNHL-BFM-90+ auto-HSCT -35 patients. R-DA-EPOCH-21 branch: 6 courses were performed. If CR was not achieved, 2 courses of R-DHAP were performed ± auto-HSCT. Branch R-mNHL-BFM-90 included 6 cycles: RA-RB-RA-RB-RA-RB. If CR was not achieved, 2 courses of R-DHAP ± auto-HSCTResults: Of 62 patients on R-DA-EPOCH-21±auto-HSCT, CR was achieved in 36 (58.1%) patients, PR was achieved in 14 (22.6%) patients, progression was reported in 6 (9.7%) patients, 3 (4.8%) patients had died, and treatment continued in 3 (4.8%) patients. Of 68 patients on R-mNHL-BFM-90±autoHSCT CR was achieved in 63 (92.7%) patients, PR was achieved in 2 (2.9%) patients, progression was not reported, 2 (2.9%) patients had died, and treatment continued in 1 (1.5%) patient. The 4-year OS of patients in the high-risk group 94% on R-mNHL-BFM-90 therapy, 81% on R-DA-EPOCH-21 therapy;. the 4-year EFS of patients in the high-risk group was 78% and 43%, respectively (p = 0.0004). Conclusion: R-mNHL-BFM-90 program is highly effective in de novo DLBCL NOS adult patients; toxicity is acceptable.
Comparison of The Use of Carvedilol Versus Nebivolol in The Treatment of Acute Decompensation in The Patient With Chronic Heart Failure: Evaluation of Clinical Variables
Authors:   Instituto de Investigaciones Cardiovasculares, Universidad de los Andes, Mérida Venezuela Correspondence, Sánchez Francisco J , García Z Jorge L ,   Instituto de Investigaciones Cardiovasculares, Universidad de los Andes, Mérida Venezuela Correspondence, Guanay Gabriela ,   Instituto de Investigaciones Cardiovasculares, Universidad de los Andes, Mérida Venezuela Correspondence, González Maite ,   Instituto de Investigaciones Cardiovasculares, Universidad de los Andes, Mérida Venezuela Correspondence, Donis José H ,   Instituto de Investigaciones Cardiovasculares, Universidad de los Andes, Mérida Venezuela Correspondence
Published: July 2023

Previous trials demonstrated the safety of using beta-blockers in the acute decompensation of heart failure; it is unknown whether the use of nebivolol translates into an improvement in clinical parameters at 96 hours, compared to the use of carvedilol in a similar study group. Objectives: To compare the effect of 2 treatment strategies, where the difference is made by the type of beta-blocker, in patients with acutely decompensated chronic heart failure. Methods: A single-center, prospective, experimental, randomized, double-blind clinical trial was carried out, 22 patients with LVEF ≤ 40% were randomly assigned to receive carvedilol or nebivolol with daily dose increase, clinical variables were measured for 96 hours. Results: The carvedilol group reached a maximum dose of 33.3 ± 10 mg and nebivolol 9.37 ± 1.25 mg, with both treatment strategies compensation was achieved in more than 50% of the patients in both groups, without statistically significant differences for the majority of patients. clinical variables, except for greater weight loss in the carvedilol group, reaching an absolute reduction of 5.62 kg (95% CI 3.22-8.02 kg) versus nebivolol with 2.54 kg (95% CI 0. 14-4.94 kg) at 96 hours of follow-up (p 0.001). Conclusions: In patients with acutely decompensated chronic heart failure and reduced LVEF, the use of beta-blockers is safe and well tolerated, guarantees clinical improvement and rapid compensation, with doses diuretic drops. The group with carvedilol showed greater weight reduction, compared to the nebivolol group in the study population.
Antioxidant Properties of Extracts From Cultured and Wild Macromycetes
Authors: Khramchankova V.
Published: July 2023

The antioxidant properties of benzene, methanol, and ethanol extracts from Agaricus bisporus, Lentinula edodes, Pleurotus ostreatus (cultivated species); Fomes fomentarius, Inonotus obliquus и Trametes versicolor (wild species) were studied. The total content of flavonoids and antioxidant activity were evaluated (DPPH, PFRAP, CUPRAC and β-carotene bleaching assay). The yield of benzene extracts was up to 1.9%; methanol up to 7.2%; ethanol to 9.6%. The content of total flavonoids in methanol and ethanol extracts from wild macromycetes was up to 29.5 mEq of rutin per gram of extract. Extracts from macromycetes showed low antioxidant activity in the PFRAP and CUPRAC reactions. It was found that methanol extracts from F. fomentarius and T. versicolor, as well as ethanol extracts from L. edodes, F. fomentarius and T. versicolor, have high antiradical activity against DPPH and β-carotene radical.
Distribution of Unionidae, Euglesidae, Pisidiidae and Corbiculidae Family Species in the Sangzor River Aquatic Ecosystems in Biotopes
Authors: Boymurodov S. , Fayzullayev U.
Published: July 2023

Our research revealed 20 species of Bivalvia, 1 subspecies and 1 variety of the Sangzor River and its surrounding aquatic species belonging to 4 families and 5 genera. Of the species listed in the table: Euglesa hissarica, E. (Casertiana) obliquata, Odhneripisidium polytimeticum are more numerous. They are found in the amount of 1-4 m per 1 m2. The rest of the species are relatively rare. Euglesa (Cyclocalyx) gurvichi, Odhneripisidium terekense, O. (Kuiperipisidium) issykkulense were first discovered in the basin of the Sangzor river. These Bivalves are crenophils and pelolimnophils living in springs depending on their habitat. The length of the Sangzor River and the presence of all biotopes in which mollusks live, made the river a favorable habitat for mollusks. However, it should be noted that while all species occur in the river, they vary in density.
Comparative Analysis of Game Development Tools
Authors: Razzhivin A. , Limanova N. , Kozlov V.
Published: July 2023

This article discusses several engines used for game development. Developers use game engines as a tool to manage complex aspects of the gameplay. The article describes several engines: Unity, Unreal Engine and Cry Engine to choose the best one for the initial stages of development. Research has shown that Unity is a suitable engine for small development teams, Unreal Engine is designed to develop high-quality games with intense graphics, while the feature of Cry Engine is to create realistic natural environments.
Уголовное преследование как вид, форма (естественное и логичное продолжение) прокурорского надзора или почему в иностранных государствах (Франция, Германия, США, Великобритания) в деятельности прокуратуры нет никакого разделения и противопоставления между уголовным преследованием и надзором
Authors: Imankulov T.
Published: July 2023

On the basis of a comparative legal analysis of the essence of the concept of ‘criminal prosecution of a prosecutor’, it was concluded that in developed European democracies in the activities of the prosecutor’s office there is no separation and opposition between criminal prosecution and supervision. In itself, the implementation of criminal prosecution by the prosecutor is considered as an activity in the interests of society and citizens on behalf of the state and only in the context of the principle of impartiality, that is, the prosecutorial criminal prosecution itself is unthinkable without the requirement of strict compliance with the law. This approach seems to be theoretically and practically correct and justified.

На основе сравнительно-правового анализа сущности понятия «уголовное преследование прокурора» сделан вывод о том, что в развитых европейских демократиях в деятельности прокуратуры нет никакого разделения и противопоставления между уголовным преследованием и надзором. Само по себе осуществление прокурором уголовного преследования рассматривается как деятельность в интересах общества и граждан от имени государства и только в контексте принципа беспристрастности, то есть само прокурорское уголовное преследование немыслимо без требования неукоснительного соблюдения закона. Такой подход представляется теоретически и практически верным и обоснованным.
Memoir Works of Tugolbai Sydykbekov
Authors: Damilova N.
Published: July 2023

In this article, the significance of memoir works in literature and socio-historical development is noted. It is noted that Kyrgyz literature also has a lot of literary masters who contributed to memoir literature, one of them is T. Sydykbekov, who is one of the main aims of literary studies to carefully study the uniqueness of memoir works, author’s skill, poetics of the work as the author’s personal findings. Aim is to reveal the Way novel by T. Sydykbekov as a memoir with evidence. The article talks about the memoir work of a famous Kyrgyz writer. The author is one of the pioneers of the memoir genre in Kyrgyz literature, has created a number of works of the memoir genre, which contribute to a deep understanding of the character of specific historical figures, their views on their position in society, the peculiarities of their activities, as well as the nature of morals, national culture and values ​​of the young generation in modern times. society. It is noted that deep understanding is a great importance in upbringing.