bluuebunny/crossref_metadata_2025 huggingface dataset:
Visual Outcome after Cataract Surgery in a South-Eastern Nigerian Tertiary Hospital
Authors:   Ophthalmology Department, Enugu State University of Science and Technology Teaching Hospital Parklane, Enugu, GC Eze , ES Onah ,   Ophthalmology Department, Enugu State University of Science and Technology Teaching Hospital Parklane, Enugu
Published: May 2024

Background: Cataract is the leading cause of reversible blindness worldwide. Aim: To evaluate the visual outcome of cataract surgeries done in a South-Eastern tertiary hospital. Methodology: The study is a 2-year retrospective study from January 2021 to December 2022. Case notes of all eligible patients that had cataract surgery within the study period were pulled out and relevant information extracted from them. Collected data was analyzed using SPSS version 21. Results were presented in percentages, tables and pie charts. Results: One hundred and eighty-two eyes were analyzed. Visual outcome continued to improve postoperatively in majority of the patients from first day to 3 months and was even better in some when corrected with glasses or with pinhole. The overall visual outcome was good in 70.3% and poor in 10.4% at 3 months. The major causes of poor visual outcome were aphakia and advanced glaucoma. Conclusion: The overall visual outcome after cataract surgery in these patients did not meet the WHO standard. Thus, there is need for training and re-training of the cataract surgeons, good patients’ selection, in-depth pre-operative work up as well as centre-based provision of needed equipments/ consumables in other to improve the visual outcome.
Foveal Changes after Uneventful Phacoemulsification Surgery for Senile Nuclear Cataract
Authors:   Department of Ophthalmology American University of Beirut Medical Center, Ibrahim Salti Haytham , George Ghazi Nicola ,   Department of Ophthalmology, LAU Medical Center Rizk Hospital
Published: May 2024

Objective: To describe foveal thickness and foveal anatomical changes after uneventful phacoemulsification surgery. Design: Interventional case control study. Participants: Both eyes of healthy phakic patients presenting to the American University of Beirut Medical Center Eye clinic for phaco-emulsification surgery in one eye (the study eye). The fellow eye served as control. Methods: OCT images of the macula were taken pre-operatively, then on a weekly basis for 12 weeks post-operatively. Outcomes: post op foveal thickness and morphological changes. Results: From the originally recruited 66 patients, 52 patients (104 eyes) completed the study. A transient increase in foveal thickness was observed in 36/52 (69%) eyes mostly between weeks 4 and7 post operatively. Twenty-seven eyes developed anatomic changes including: microcysts in 15 eyes (55%), regular cysts in 6 eyes (22%), and epiretinal membranes in 6 eyes (11.5%). Changes appeared as early as 1 week post operatively, and lasted on the average 4 weeks. Conclusion: Uncomplicated cataract surgery can lead to transient thickening of the macula as well as morphological changes.
The Effect of Dissatisfaction on Complaining Behavior of Delivery App
Authors:   The Foodservice Management Society Of Korea, Kim Youn-Min
Published: May 2024

The purpose of this study was to identify dissatisfaction factors and complaint behavior factors for delivery apps and to investigate the influence of dissatisfaction factors on complaint behavior through empirical analysis. To achieve the purpose of this study, a survey using convenience sampling was conducted targeting adults who had experienced dissatisfaction and complaint behavior with delivery apps, focusing on Seoul and the metropolitan area. The questionnaires were distributed from January 15, 2024 to January 29, 2024. 250 of which 15 inappropriate questionnaires were excluded and only 235 were used as final data for empirical analysis. The analysis results are as follows. First, among the dissatisfaction factors with delivery apps, system dissatisfaction had a significant effect on private complaint behavior. Second, among the dissatisfaction factors with delivery apps, system dissatisfaction, cancellation and refund dissatisfaction, and delivery time dissatisfaction had a significant effect on public complaint behavior. The results of this study provided basis for exploring efficient strategic measures for dissatisfaction by identifying the dissatisfaction and complaint behavior of delivery app consumers.
The Impact of Young Cooks' Perceived Work Environment on Self-efficacy and Turnover Intention
Authors:   The Foodservice Management Society Of Korea, Yoon Ji-Won , Lee Jong-Min
Published: May 2024

The purpose of this study is to uncover the turnover intention of MZ generation cooks, that is, young cooks, and to find out the factors that can lower it. Therefore, to find out the effect of the work environment perceived by young cooks on self-efficacy and turnover intention. An empirical analysis was conducted targeting cooks aged 19 to 34 working in the restaurant industry in Korea. The results of the analysis showed that work environment affects self-efficacy and that high self-efficacy lowers turnover intention. The better the facility environment and welfare environment, the lower the intention to change jobs. Therefore, in order to lower the turnover cost of young cooks, self-efficacy must be increased by investing in the facility environment among the working environment, and factors related to the welfare environment will also be improved to reduce the turnover of young cooks, thereby reducing turnover costs and new recruitment costs.
The Effect of Regular Restaurant Consumption Experience on Place Attachment and Behavioral Intention
Authors:   The Foodservice Management Society Of Korea, Lee Ki-Seoung
Published: May 2024

In this study, the consumption experience of a regular restaurant was divided into four types of experiences and the structural influence relationship between place attachment and behavioral intention and the influence relationship between consumption experience and behavioral intention with place attachment playing a mediating role were identified. A total of 318 samples were coded in the form of an online questionnaire from January 10 to January 20, 2023, and used for statistical analysis using programs of SPSS 21.0 and AMOS 18.0. First, the behavioral, cognitive, and emotional experiences of regular restaurant consumption had a positive effect on place attachment. Second, behavioral and cognitive experiences of regular restaurant consumption had a positive effect on behavioral intention. Third, place attachment had a positive effect on behavioral intention. Fourth, the behavioral and cognitive experiences of the regular restaurant had indirect effects on behavioral intention through attachment to place. Therefore, a good experience and place at a regular restaurant can be a means and weapon to attract customers, and it is important to increase market share through continuous visits and recommendations by increasing new customers and creating loyal customers.
The Effects of Dietary Lifestyle on Purchase Intention of Convenience Store Lunch Box: Mediating Role of Perceived Quality of Convenience Store Lunch Box
Authors:   The Foodservice Management Society Of Korea, Lee Myung Chul
Published: May 2024

We examined the impact of dietary lifestyle on purchase intention of convenience store lunch boxes and the mediating role of perceived quality. This study conducted a survey using the convenience sampling method targeting consumers who had experience purchasing convenience store lunch boxes in Seoul, Gyeonggi, Daejeon, and Gwangju from February 19 to February 25, 2024. We used 251 copies of the questionnaire as final analysis data, and analysis was conducted using the SPSS 23.0 package program. The analysis is summarized as follows. First, the health-seeking type of dietary lifestyle had a significant impact on the purchase intention of convenience store lunch boxes. On the other hand, the convenience-seeking type had no significant effect on the purchase intention of convenience store lunch boxes. Second, perceived quality was found to play a mediating role between health-seeking dietary lifestyle and purchase intention of convenience store lunch boxes. The results of this study provided basic data that could contribute to the development of convenience store lunch box products and increase sales by understanding consumers' dietary lifestyles.
The impact of experience with robot baristas on relationship quality and intention to reuse
Authors:   The Foodservice Management Society Of Korea, Kang Kyung-Tae
Published: May 2024

The purpose of this study is to investigate the influence of experience with robot baristas on the quality of relationships and intention to reuse. This study was limited to users with experience with robot baristas in the Seoul area and used a Judgment sampling method among non-probability sampling methods. The survey questions consisted of a total of 19 items, and an online survey was conducted using Google. The data used in this study was the SPSS 27.0 program. As a result of hypothesis testing, Hypothesis 1 experience had a positive (+) effect on the quality of relationships. Hypothesis 2 Relationship quality had a positive (+) effect on reuse intention. Hypothesis 3 Experience had a positive effect on intention to reuse. This study is different from existing research by conducting a study on the impact of experience with a robot barista on relationship quality and reuse intention. We hope that the analysis results will be used as basic academic data and achievements in food tech-related fields.
A Study on the Moderating Effect of Local Food Involvement in the Differences of Selection Attributes and Behavioral Intentions of Marine and Leisure Tourist Resorts - Focusing on Busan and Yeosu -
Authors:   The Foodservice Management Society Of Korea, Lee Won-Sol
Published: May 2024

This study was conducted for visitors to Busan and Yeosu to find out what moderating effect and selection attribute the local food's involvement in the selection attribute of marine tourist destinations has on the intention of action. As a result of the study, first, as a result of comparing the difference between the visited areas for the selection attribute of marine tourist destinations in Hypothesis 1, it was found that there were significant differences in leisure facilities, convenience facilities, and food. Second, in the relationship between the selection attribute of marine tourist destinations and the involvement of local foods, convenience facilities and food were found to have an effect, and environment and leisure facilities were rejected. Third, in the relationship between the selection attribute of marine tourist destinations and the intention of action, it was found that environment, leisure facilities, and food had an effect, and convenience facilities were rejected.
Effect of bakery cafe SNS word-of-mouth information characteristics on trust, word-of-mouth acceptance and sharing behavior, and revisit intention
Authors:   The Foodservice Management Society Of Korea, Ha Yeon-Ok , Kwon Mi-Ryon , Yang Su-Hyun
Published: May 2024

In this study, we examined the relationship between bakery cafe SNS word-of-mouth information characteristics and trust, word-of-mouth acceptance and sharing behavior, and revisit intention, and verified the correlation between each factor. Among the bakery cafe SNS word-of-mouth information characteristic factors, agreeability and liveliness were found to have an effect on trust, while the timeliness factor was found to have no effect. Trust was found to have an effect on word-of-mouth acceptance, and word-of-mouth acceptance was found to have an effect on sharing behavior and revisit intention. These research results are meaningful in activating more effective and useful marketing strategies in the bakery industry.
Big Data Analysis of Greenwashing Awareness and Issues: Focusing on Starbucks
Authors:   The Foodservice Management Society Of Korea, Lee Chae-Eun , Lee Jin-Young
Published: May 2024

This study conducted big data analysis using text mining to investigate Starbucks’ perception of greenwashing and social issues. Starbucks’ greenwashing-related keywords were collected through portal sites such as Naver, Daum, Google, and Big Kines’ newspapers, and 11,522 keywords were derived using Textom. The results of analyzing UCINET 6 and NetDraw as the top 50 keywords are as follows. First, as a result of the degree centrality analysis, the centrality was high in the order of ‘reusable cup’, ‘eco-friendly’, ‘paper straw’, ‘plastic’, ‘use’, ‘controversy’, ‘reusable container’, and ‘marketing’. Second, the eigenvector was influential in the order of ‘reusable cup’, ‘eco-friendly’, ‘paper straw’, ‘plastic’, ‘use’, ‘controversy’, ‘multiple containers’, ‘event’, and ‘environment’. In this study, the results of clustering through CONCOR analysis were classified into four groups: ‘brand image’, ‘disguised environmentalism controversy’, ‘eco-friendly policy’, and ‘reusable cup evaluation’. In this study, Starbucks’ perception of greenwashing and issues were identified, and it is expected that it will be provided as a guideline for companies to build effective marketing strategies for sustainable growth by referring to basic data on eco-friendly management in the future.
Research Trend Analysis to Verify the Moderating Effect in 「Journal of Foodservice Management」: For Papers Published from the First Issue in 1998 to 2023
Authors:   The Foodservice Management Society Of Korea, Moon Sung-Sik
Published: May 2024

In this study, we looked at research trends on verification of mediation effects through papers published in 「Restaurant Management Research」. As a result of the analysis, first, recently (since 2020), interest in the mediation effect among restaurant management researchers has increased. Second, regression analysis and structural equation modeling are mainly used as mediation effect verification methodologies. Third, the mainly used parameters are customer satisfaction, self-efficacy, trust, perceived value, innovative behavior, subjective norm, primary satisfaction, and emotional response. And after 2020, trust, emotional response, and subjective norm were used a lot. The results of this study will be able to provide basic information to restaurant management researchers who wish to conduct research to verify mediation effects in the future. It is also meaningful in that it provides a theoretical basis for selecting appropriate parameters according to the characteristics of the research subject.
FPGA Based Efficient Detection of Blood Group and Hb-anemic Using Image Processing-VLSI Approach
Authors: Chairman M  , Deepak M  , Priyatharsini S  , Maragatharaj S
Published: May 2024

During the critical situation of a patient, an immediate blood transfusion from others to a patient is necessary. The blood groups are AB, B, A and O. The identification of the blood group and Hb- anemic help to decide blood transfusion during emergencies. In order to check anaemia as well as to take complete blood count and to monitor a number of diseases, the hemoglobin test is an important one. But both tests are not possible in remote and village areas, because they require additional equipments and trained personnel which can be afforded only in lab. The conventional test methods involve the risk of infection, possibility of occurring human errors, more time consumption and noise interference. By addressing these limitations, an effective hardware system is proposed to detect blood group and Hbanemic by exploiting image processing mechanism with FPGA based VLSI process. The front-end model was developed using MATLAB software, where the input blood sample images were converted into gray-scale and perform GLCM model to generate the statistical parameters. The back-end model was developed using XILINX FPGA Spartan 6 kit/ Altera Quartus Ⅱ. The data with code is then fed to hardware kit to compare and correlate with the training samples using Stump Boost Regression Algorithm (SBRA). We considered World Health Organization (WHO)'s HCS method to detect Hb-anemic. The proposed system shows improved performance, optimal accuracy, less error rate and less time with low cost. This system can be used as a technician-free self-testing device, minimising the exposure of patients to clinical settings.
Enhancing Cyber-Physical Systems Dependability through Integrated CPS-IoT Monitoring
Authors: Anitha Cuddapah , Tellur Anil , Brahma Rao KBV , Kumbhar Vijaya , Gopi Telagamalla , Jadhav Sachin , RG Vidhya
Published: May 2024

This abstract investigates the convergence of collection tree protocols, cyber-physical systems (CPS), dependability, epidemic modelling, the Fourth Industrial Revolution (4IR), and the Internet of Things (IoT). Our research focuses on improving the dependability of Cyber-Physical Systems (CPS) by examining the incorporation of Internet of Things (IoT) monitoring and collecting tree protocols. The objective of the study is to develop a strong framework for collecting and analysing data in real-time. This will be done by using epidemic modelling to forecast and avoid system breakdowns. Within the framework of the Fourth Industrial Revolution, the study focuses on highlighting adaptive and fault-tolerant designs for Cyber-Physical Systems (CPS). By integrating these technologies, we tackle issues related to the reliability of systems, providing valuable knowledge on flexible adjustment, robustness, and uniform communication protocols. This book makes a valuable contribution to the changing field of Cyber-Physical Systems (CPS), providing a comprehensive methodology that is in line with the revolutionary possibilities of the Fourth Industrial Revolution
Coupling of Rough Set Theory and Predictive Power of SVM Towards Mining of Missing Data
Authors: Bhagat Surendra Nath , Rath Premansu Sekhar , Mitra Anirban
Published: May 2024

Rough set theory offers a novel approach to identifying structural correlations amidst imprecise or noisy data, particularly applicable to variables with diverse values. It presents a promising avenue for handling fuzzy, conflicting, and uncertain data, with recent models incorporating various fuzzy generalizations. This technique stands out as a popular solution within artificial intelligence, particularly in data analysis and processing tasks. In the medical domain, where missing data poses a significant challenge, leveraging rough set theory alongside machine learning algorithms for disease prediction is common. This paper proposes a model that effectively predicts missing values using rough set theory, addressing the prevalent issue of incomplete data. By providing a systematic approach and robust algorithm, the model demonstrates the adaptability and potential of rough set theory in contemporary data analysis scenarios. Classification of the predicted data set using supervised Learning Model (SVM) results in accuracy of 82.1% while the F1 score is 82.6%. Through validation with reallife medical datasets using supervised classification techniques, the paper underscores the accuracy and applicability of the proposed algorithm, offering a valuable tool for researchers and practitioners grappling with the complexities of modern data analysis.
Comprehending AI's Role in Literature and Arts from a Transhumanist Perspective
Authors: Jerrin Neil Beeto , Bhuvaneswari G
Published: May 2024

This research paper embarks on a journey into the transhumanistic intersection between human intelligence and Artificial Intelligence (AI) in the context of producing literature and arts. It argues that human-AI collaboration is a catalytic process for expansion and innovation, with AI emerging as a potential creative partner. This exploration delves into how AI can serve as an extension of human articulation, enhancing artistic capabilities and broadening the horizons of artistic expression. The study underscores the pivotal role of AI in artistic domains by tracing its historical development in creative fields, examining collaborations between human artists and AI systems, and exploring real-world applications to illuminate the potential advantages and challenges of AI-aided creativity. The paper further delves into the ethical and philosophical considerations surrounding authorship, authenticity, and human intervention in AI-generated elements, as well as their societal and cultural implications, offering a glimpse into how AI applications are reshaping contemporary society. Moreover, the research probes into how AI-generated art disrupts traditional aesthetic art forms, reshapes artistic norms, and fosters versatile interpretations. By scrutinizing the potential impacts and risks associated with AI in literature and arts, this research paper aims to shed light on the symbiotic power of AI as an extension of human intelligence in the creative spectrum within the framework of Transhumanism.
Tele-dentistry: An Alternative Dental Care Access
Authors: Naik Debasruti , Giri Motirmoy , Sahu Nikita , Das Utkalika
Published: May 2024

In the practice of tele-dentistry, online consultation is done and the basic oral care advice and service is provided via a virtual platform. Tele-dentistry increases the efficiency and impact of dentistry by promoting collaboration and connecting dental care providers to patients in need. This article review and discuss the applications and scope of teledentistry as a part of health care services to both urban and rural population. Articles on tele-dentistry were searched and reviewed from various databases like PubMed, Science Direct, Google Scholar, and Cochrane database. Teledentistry assisted healthcare delivery can be an ideal set up in India. It can create prospect for all kind of healthcare specialist along with dental specialist to work out together. Tele-dentistry will be just an alternative way of accessibility to medical facilities. The prospective of tele-dentistry will definitely be a remarkable in the future in India
La neurotomía periférica selectiva (NPS) en el tratamiento quirúrgico de la espasticidad
Authors: Cubillos Lobos Alejandro
Published: May 2024

La neurotomía periférica selectiva (NPS) en el tratamiento quirúrgico de la espasticidad
Nuevas estrategias neuro-oncológicas en el tratamiento de gliomas
Authors: Ottaviano Fabio H.
Published: May 2024

Nuevas estrategias neuro-oncológicas en el tratamiento de gliomas
New staging of endometrial carcinoma – FIGO 2023
Authors:   Department of Gynecology and Obstetrics, 3rd Medical Faculty, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic, Hruda Martin , Sehnal Borek , Halaška Michael J. , Drozenová Jana , Robová Helena , Pichlík Tomáš , Rob Lukáš
Published: May 2024

Aim: To review the changes in the new version of the FIGO 2023 staging system for endometrial cancer. Methods and results: The new FIGO 2023 endometrial cancer staging system provides key updates for the diagnosis and treatment of endometrial cancer. An important step in diagnosis is molecular classification, which allows more accurate risk stratification for recurrence and the identification of targeted therapies. The new staging system, based on the recommendations of the international societies ESGO, ESTRO and ESP, incorporates not only the description of the pathological and anatomical extent of the disease, but also the histopathological characteristics of the tumour, including the histological type and the presence of lymphovascular space invasion. In addition, the staging system uses molecular testing to classify endometrial cancers into four prognostic groups: POLEmut, MMRd, NSMP and p53abn. Each group has its own specific characteristics and prognosis. The most significant changes have occurred in stages I and II, in which the sub-staging better reflects the biological behaviour of the tumour. This update increases the accuracy of prognosis and improves individualized treatment options for patients with endometrial cancer. Conclusion: The updated FIGO staging of endometrial cancer for 2023 incorporates different histologic types, tumour features, and molecular classifications to better reflect the current improved understanding of the complex nature of several endometrial cancer types and their underlying bio logic behaviour. The aim of the new endometrial cancer staging system is to better define stages with similar prognosis, allowing for more precise indication of individualised adjuvant radiation or systemic treatment, including the use of immunotherapy. Key words: endometrial cancer – FIGO – staging – molecular classification – update
A new perspective on Endometrial Carcinoma classification and management strategies in context of molecular subtypes
Authors:   Department of Gynaecology nad Obstetrics, Faculty of Medicine, University P. J. Safarik in Košice, Hospital AGEL Košice-Šaca Inc., Slovak Republic, Ballová Zuzana , Gašparová Petra , Sitáš Martina , Dosedla Erik
Published: May 2024

Endometrial cancer is the most common gynecological cancer and the second most prevalent female malignancy in the developed world. It is typically diagnosed in postmenopausal women, presenting with the characteristic clinical symptom of uterine abnormal bleeding. In the past, only two histological types were considered. However, it has become increasingly evident that endometrial cancer is a clinically heterogeneous disease, and this heterogeneity is closely associated with the diversity of underlying molecular alterations. The Cancer Genome Atlas classification has significantly advanced the diagnosis, risk stratification, and management of endometrial cancer by categorizing it into four molecular subgroups, each characterized by distinct mutational burdens and copy number alterations. Key words: endometrial cancer – molecular classification – POLE mutation – The Cancer Genome Atlas Research Network – hysterectomy – targeted therapy – mismatch-repair – p53
Artificial activation of sperm motility in vitro
Authors:   Repromeda s.r.o., Brno, Czech Republic, Trávník Pavel , Ješeta Michal , Hüttelová Renata , Křen Radomír , Landsmann Lukáš , Nesvadbová Andrea , Tauwinklová Gabriela
Published: May 2024

Aim: The sperm activation method is a modern methodological approach that is used more and more often in practice. The number of studies focused on methods of artificial activation of human sperm motility are constantly increasing. Standard sperm selection methods can fail in some cases, among other things, because very young sperm are isolated that have not yet completed their development. In these cases, artificial stimulation of their movement can have a positive effect and greatly facilitate and faster the process of selecting suitable sperm. Methylxanthines are most often used as activating agents. However, opinions on the safety of using these substances on sperm are not uniform. The aim of the thesis is to present current knowledge about artificial activation of sperm motility for in vitro fertilization and subsequent embryonic development. Methodology: Research of relevant literature in Web of Science, Scopus, PubMed/Medline databases. Results and conclusion: The literature analysis shows that this method is safe and effective in the selection of immotile spermatozoa. Scientific studies have been conducted to verify the safety and reliability of this method. The conclusion of these studies is the positive impact of this method of selection, especially in cases of sperm obtained from testicular tissue after method testicular sperm extraction. In these cases, the method of artificial sperm activation facilitated and accelerated the selection of sperm before intracytoplasmic sperm injection. Undamaged spermatozoa, which are immobile due to incomplete maturation, were activated. Key words: spermatozoa – in vitro fertilization – motility – theophylline
Metrics of uterine myomatosis symptomatology in clinical practice
Authors:   Department of Obstetrics and Gynecology, Medical Faculty of Masaryk University and University Hospital Brno, Czech Republic, Hudeček Robert , Mekiňová Lenka , Šimová Soňa , Bánovská Lucie , Hledíková Andrea
Published: May 2024

Aim: A review of diagnostic options and standardized methods for specifying clinical symptoms associated with uterine myomatosis. Methods: A literature search of databases aimed at finding validated metrics for assessing myomas symptomatology. Results: Summary of obligatory and optional examination methods in the diagnosis of uterine fibroids and methods of examination of reproductive parameters of the couple in relation to myomatosis. Defining the metrics of bleeding manifestations of myomatosis with emphasis on the “Pictorial Bleeding Assessment Chart”. Reviewing metrics of algic manifestations of myomatosis and quality of life with emphasis on the “Quality of Life Questionnaire – Myomatosis – Severity Symptom Scale”. Conclusion: The purpose of the applicable metrics, which summarize objective findings and subjective complaints of patients, is to describe and evaluate possible correlations and dynamics of changes in the health status, depending on the chosen therapy. Key words: uterine fibroid symptoms
Trophoblast stem cells, trophoblast invasion, and organoids – advancements in gynecology
Authors:   Department of Gynaecology nad Obstetrics, Faculty of Medicine, University P. J. Safarik in Košice, Hospital AGEL Košice-Šaca Inc., Slovak Republic, Gašparová Petra , Ballová Zuzana , Bačenková Darina , Trebuňová Marianna , Dosedla Erik
Published: May 2024

The human placenta serves as a vital barrier between the mother and the developing fetus during pregnancy. A defect in the early development of the placenta is associated with severe pregnancy disorders. Despite its complex development, various molecular processes control placental development, and the specialization of trophoblast cells is still not fully understood. One primary obstacle is the lack of suitable cell model systems. Traditional two-dimensional (2D) cell cultures fail to mimic in vivo conditions and do not capture the intricate intercellular interactions vital for studying placental development. However, three-dimensional (3D) organoid models derived from stem cells that replicate natural cell organization and architecture have greatly improved our understanding of trophoblast behavior and its medicinal applications. Organoids with relevant phenotypes provide a valuable platform to model both placental physiology and pathology, including the modeling of placental disorders. They hold great promise for personalized medicine, improved diagnostics, and the evaluation of pharmaceutical drug efficacy and safety. This article provides a concise overview of trophoblast stem cells, trophoblast invasion, and the evolving role of organoids in gynecology. Key words: trophoblast stem cells – trophoblast invasion – organoids – pregnancy complications
Dynamics of serum levels and reference ranges of copeptin in the 3rd trimester of pregnancy in healthy pregnant women with uncomplicated pregnancy and delivery
Authors:   Department of Obstetrics and Gynecology, Faculty of Medicine, Palacky University and University Hospital Olomouc, Czech Republic, Roubalova Lucie , Gardo Alzbeta , Horejskova Sabina , Dudova Alexandra , Krofta Ladislav , Lubusky Marek
Published: May 2024

Objective: Copeptin is a stable fragment of vasopressin. Copeptin levels have been found to reflect the degree of endothelial stress in various conditions, including acute coronary syndrome. Copeptin may be a bio marker for endothelial stress during pregnancy. However, there is still a lack of understanding of its dynamics and levels throughout pregnancy. This study aims to describe intra-individual and longitudinal changes in copeptin levels at 30th and 36th gestational weeks in healthy pregnant women with uncomplicated pregnancy and delivery and to establish specific reference ranges. Methods: A total of 125 pregnant women with uncomplicated pregnancy and delivery were included. These women were monitored throughout their pregnancy and gave birth at the Department of Obstetrics and Gynecology Olomouc University Hospital. The blood was taken at ~30 and ~36 gestational weeks. Serum copeptin levels were measured using a Kryptor Compact PLUS analyzer. For statistics, we used R software and the "referenceRanges" package. Results: It was found that serum levels of copeptin were significantly higher in the 36th week group than in the 30th week group (P < 0.05). Cook's distance was used to eliminate outliers. The 30th week median was 3.377 pmol/l, reference range = 1.343–7.829 pmol/l, and the 36 week was median 4.735 pmol/l and reference range = 2.06–13.2 pmol/l. In the 36th week reference range, the median was higher than in healthy, non-pregnant women (P < 0.05). Copeptin values can exceed 10 pmol/l, particularly after the 36th week. In the 3rd trimester, this value may indicate cardiovascular and endothelial overload. Conclusion: Copeptin levels were found to vary significantly depending on gestational week. The proposed reference ranges take into account the increased secretion of vasopressin in pregnancy. The existence of specific upper reference limits represents a potential advantage in detecting pregnant women prone to hypertensive disease in the 3rd trimester. Key words: copeptin – vasopressin – preeclampsia – gestational hypertension – reference ranges – pregnancy
Liver transplantation for acute liver failure
Authors: Kieslichová Eva
Published: May 2024

Summary: Acute liver failure is a rare, highly devastating, potentially reversible condition characterised by the sudden onset of severe liver dysfunction in individuals without pre-existing liver disease and with a poor prognosis. In recent decades, advances in the diagnosis of the disease, a better understanding of its pathophysiology and the development of supportive care have improved the prognosis of patients with acute liver failure. However, despite the success of conservative therapy, urgent liver transplantation remains the only chance of survival for a large proportion of patients with acute liver failure. Early diagnosis of the disease, implementation of supportive care and identification of patients indicated for urgent liver transplantation are essential measures in the management of patients with acute liver failure. Key words: acute liver failure – transplantation – supportive therapy – prognostic criteria
Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria
Authors: Odunlami Gbenga Joshua , Ajibade Adeola , Omotosho Bolanle Aderonke , Hassan Muzamil Olamide , Adefidipe Adeyemi Abiola , Olanrewaju Fatai Olatunde , Enitan Ademola Olusegun , Adetunji Tajudin Adesegun , Akinyele Olumide Akinniyi , Okunola Oluyomi
Published: May 2024

Introduction

The aims were to study the sociodemographic characteristics of patients presenting to the clinic and to study the clinical and serological pattern of systemic lupus erythematosus (SLE) in a new rheumatology clinic of a predominantly Yoruba population.

Material and methods

This was a retrospective, cross-sectional study conducted over 7 years (January 2017 – December 2023). Patients who satisfied the 1997 American College of Rheumatology (ACR) and/or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria were enrolled using their medical records. Patients with overlap syndromes and other inflammatory or noninflammatory rheumatic diseases were excluded from the study. Their sociodemographic, clinical, laboratory, and treatment data were retrieved from their medical records and analysed using IBM SPSS version 23.0 software.

Results

A total of 65 patients were diagnosed with SLE with a frequency of 15.8%. The mean age ±SD of the patients at presentation was 33.85 years ±11.01 and the female to male ratio was 9.8 : 1. The median (IQR) duration of symptoms at presentation was 7.0 months (3–24). The common clinical presentations included synovitis (86.2%), acute cutaneous rash (53.8%), oral ulcers (52.3%), nonscarring alopecia (50.8%), and serositis (47.7%). Proteinuria was seen in 37.7% of the patients and the predominant renal histopathological feature was Class IV. Antinuclear antibody was 100% positive with 50.94% of the patients having a titre of 1 : 5,120 and above. Anti- double-stranded deoxyribonucleic acid and anti-Smith antibodies each had 50% prevalence. Dyslipidaemia was found in 76.7% of the patients.

Conclusions

The study’s findings are largely consistent with similar studies done in Africa. Further prospective multi-centred studies are needed to further determine the epidemiological characteristics of the disease in Nigeria with a multi-ethnic population.
ĐIỀU TRỊ PHẪU THUẬT UNG THƯ ĐẠI TRÀNG PHẢI XÂM LẤN ĐẦU TỤY TÁ TRÀNG
Authors: Thái Nguyên Hưng , Khổng Văn Quang
Published: May 2024

Đặt vấn đề: Ung thư đại tràng phải (UTĐTP) tiến triển tại chỗ xâm lấn đầu tụy và hoặc tá tràng là tổn thương hiếm gặp. Phẫu thuật triệt căn bao gồm cắt ½ đại tràng phải và cắt khối tá tụy hoặc cắt đoạn tá tràng còn gặp nhiều khó khăn do tỷ lệ tử vong và biến chứng cao. Mổ nối tắt hoặc cắt đại tràng phải (diện cắt R1-2) có thời gian sống ngắn. Bởi vậy chúng tôi nghiên cứu đề tài nằm nhằm mục tiêu mô tả các đặc điểm lâm sàng, cận lâm sàng và đánh giá kết quả phẫu thuật của ung thư đại tràng phải tiến triển tại chỗ, xâm lấn tá tràng và hoặc đầu tụy. Đối tượng và phương pháp nghiên cứu: Nghiên cứu hồi cứu những BN được chẩn đoán ung thư đại tràng phải xâm lấn tá tràng và/hoặc đầu tụy, được phẫu thuật tại khoa ngoại bụng 2, BV K. Kết quả nghiên cứu: 7 BN, Nữ 6/7 BN (85,7%), Nam 1/7 BN (14,3%) tuổi TB 58,3T, 100% có bán tắc ruột, 3/7 BN (42,8%) khám bụng sờ thấy khối U. CLVT phát hiện khối U ĐTP 100%. CLVT không phát hiện khối UTĐTP xâm lấn tá tràng hay đầu tụy. Kết quả NSĐT 6/7 BN (85,7%) có khối u gây hẹp lòng ĐT. Nội soi dạ dày nghi thủng tá tràng 1 BN. Tổn thương trong mổ: 5/7 BN UTĐTP xâm lấn tá tràng (1UTĐTP thủng vào DII tá tràng trên bóng Vater; 2 UTĐTP thủng vào DII-DIII tá tràng; 2 UTĐTP xâm lấn gối dưới tá tràng), kích thước khối ung thư TB 7,6 cm (5-10 cm), thời gian mổ TB 3,3 h; Phẫu thuật cắt ½ ĐTP - cắt đoạn DII tá tràng, cắt hang vị, dẫn lưu (DL) mỏm tá tràng 1 BN; Cắt ½ ĐTP+ cắt đoạn DII-DIII tá tràng, cắt hang vị, DL mỏm tá tràng 2 BN, cắt ½ ĐTP, khâu gối dưới tá tràng, nối vị tràng 2 BN; cắt ½ ĐTP, nối vị tràng 2 BN; Thời gian nằm viện TB 10,7 ngày, Không có BN tử vong (TV), 2 BN nhiễm trùng vết mổ, 2 BN rò < 50-100ml/24. Kết quả GPB: ung thư biểu mô tuyến T4aN0M1 2 BN;T4bN0M0 5 BN. Kết luận: Ung thư đại tràng phải xâm lấn tá tràng và hoặc đầu tụy có thể  phẫu thuật (PT) triệt căn  khi chưa có di căn xa. PT triệt căn bao gồm cắt ½ đại tràng phải và cắt khối tá tụy có tỷ lệ tử vong và biến chứng cao đối với bệnh nhân có nguy cơ phẫu thuật cao và nhiều bệnh toàn thân phối hợp. Mổ cắt ½ ĐTP và cắt đoạn tá tràng hoặc cắt ½ ĐTP và cắt tá tràng hình chêm là lựa chon phù hợp, có tỷ lệ tử vong và biến chứng thấp hơn, khi ung thư chỉ xâm lấn tá tràng với điều kiện đạt được diện cắt an toàn (1cm cách vùng tá tràng xâm lấn). Mổ cắt 1/2 ĐTP palliative (diện cắt R1-2) hoặc nối tắt có thời gian sống thêm ngắn (9- 11 tháng).
MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ HÌNH ẢNH TỔN THƯƠNG TRÊN PHIM CHỤP CỘNG HƯỞNG TỪ Ở BỆNH NHÂN NGỘ ĐỘC KHÍ N2O ĐIỀU TRỊ TẠI TRUNG TÂM CHỐNG ĐỘC
Authors: Bùi Như Quỳnh , Đỗ Thị Hồng Loan , Nguyễn Thị Thu Hương , Đỗ Thị Hằng , Bùi Ngọc Thu Hiền , Hà Kiều Lâm , Nguyễn Tiến Hoàng Anh , Nguyễn Như Quỳnh , Nguyễn Hồng Diệp , Lê Tuấn Vũ , Huỳnh Thị Nhung , Lê Quang Thuận
Published: May 2024

Mục tiêu: Mô tả đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị bệnh nhân ngộ độc khí N2O điều trị tại Trung tâm Chống độc, Bệnh viện Bạch Mai 2022-2023. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang, hồi cứu 32 bệnh nhân được chẩn đoán ngộ độc N2O từ 04/2022 đến 04/2023 tại Trung tâm Chống độc, Bệnh viện Bạch Mai. Kết quả: Bệnh nhân ngộ độc N2O hay gặp triệu chứng thần kinh, tâm thần như: tê bì 96,9%, yếu liệt chi 59,4%, giảm cảm giác 34,4%, thay đổi hành vi 12,5%. Nồng độ homocystein trung bình tăng 80,29 ± 17,93 μmol/L, nồng độ vitamin B12 trung bình 304,55 ± 83,01 pmol/L. Chụp cộng hưởng từ tổn thương nhiều hơn ở các đốt C3 đến C6 (tổn thương C3 là 40%, C4 là 45%, C5 là 45%, C6 là 30,1%) tiếp đến là tổn thương ở tủy ngực (dưới 20%) và thắt lưng ít gặp hơn (dưới 5%). Tổn thương tủy có dấu hiệu “chữ V ngược” gặp ở 14 bệnh nhân chiếm tỷ lệ 75%. Nồng độ vitamin B12 ở nhóm bệnh nhân có dấu hiệu “chữ V ngược” thấp hơn nhóm bệnh nhân không có dấu hiệu này. Đa số bệnh nhân sau điều trị lúc ra viện đã đỡ các triệu chứng lâm sàng. Kết luận: Ngộ độc N2O gây ra các triệu chứng về thần kinh, tâm thần; xét nghiệm homocystein có mức độ tin cậy tốt hơn vitamin B12 trong chẩn đoán ngộ độc N2O; tổn thương điển hình trên hình chụp cộng hưởng từ là dấu hiệu “chữ V ngược” có liên quan đến giảm vitamin B12.
MỐI LIÊN QUAN GIỮA NGHIỆM PHÁP ĐI BỘ 6 PHÚT VÀ TỶ LỆ TÁI NHẬP VIỆN Ở NGƯỜI BỆNH SUY TIM MẠN ĐIỀU TRỊ NGOẠI TRÚ TẠI BỆNH VIỆN ĐA KHOA ĐỨC GIANG NĂM 2023
Authors: Đào Chiến Thắng , Phạm Huy Hùng , Đỗ Thị Trang , Vũ Thị Bảo Ngân , Phạm Thị Mai Hương
Published: May 2024

Mục tiêu: Phân tích mối liên quan giữa nghiệm pháp đi bộ 6 phút và tỷ lệ tái nhập viện ở người bệnh suy tim mạn điều trị ngoại trú tại Bệnh viện Đa khoa Đức Giang năm 2023. Đối tượng và phương pháp: sử dụng thiết kế mô tả theo dõi dọc 109 người bệnh suy tim mạn điều trị ngoại trú đến khám định kỳ có chỉ định thực hiện nghiệm pháp đi bộ 6 phút từ 05/2023 đến 09/2023 tại khoa Nội Tim mạch – Bệnh viện Đa khoa Đức Giang. Kết quả: 20,78% BN gặp biến cố tái nhập viện. Thời gian tái nhập viện trung bình của nhóm chung: 33,3 ± 14,0. Điểm cắt của quãng đường đi bộ trong nghiệm pháp đi bộ 6 phút tiên lượng tái nhập viện trong vòng 90 ngày sau xuất viện là 305 mét. Thời gian tái nhập viện trung bình của nhóm đi bộ < 305 m là: 29,1 ± 12,0. Thời gian tái nhập viện trung bình của nhóm đi bộ ≥ 305 m là: 37,5 ± 16,0. Kết luận: Nghiệm pháp đi bộ 6 phút nên được xem xét thực hiện ở người bệnh suy tim điều trị ngoại trú đến khám bệnh định kỳ để đánh giá mức độ gắng sức và tư vấn cho người bệnh về chế độ sinh hoạt, lao động hàng ngày. Hơn nữa, nghiệm pháp đi bộ 6 phút có giá trị dự đoán tái nhập viện trong vòng 90 ngày do suy tim.
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ PHẪU THUẬT UNG THƯ VÀ CÁC KHỐI U TÁ TRÀNG
Authors: Thái Nguyên Hưng , Khổng Văn Quang
Published: May 2024

Nghiên cứu hồi cứu mô tả đặc điểm  lâm sàng, cận lâm sàng  cũng như đánh giá kết quả phẫu thuật  ung thư tá tràng và các khối u tá tràng. Có 10 BN, Nam  60% (6 BN) Nữ 40% (4 BN). Tuổi TB 52,5. Triệu chứng lâm sàng (LS) thường gặp: đau bụng 90%, xuất huyết tiêu hóa (XHTH) 30%, hẹp tá tràng 30%. Chụp CLVT phát hiện U tá tràng 90%; Nội soi dạ dày (NSDD) phát hiện u 60% (50% U D' niêm mạc). Siêu âm nôi soi (SANS) 20% (phát hiện GIST 20%). Mổ cấp cứu (sốc mất máu) 20%, mổ phiên 80%. Tổn thương: Ung thư DII  tá tràng (adenocarcinoma: AC) 1 BN (10%), GIST DII tá tràng 2 BN (20%), GIST DII-DIII 3 BN (30%), GIST DIII-IV 1 BN (10%), U lympho  DIV 1 BN (10%), U cơ  DII (leiomyoma) 2 BN (20%). Phẫu thuật cắt khối tá tụy 1 BN; Cắt đoạn DII trên Vater, cắt bán phần dạ dày, dẫn lưu (DL) mỏm tá tràng 1BN (10%); Cắt đoạn DII D' bóng Vater, cắt hang vị, Dl mỏm tá tràng 1 BN (10%); Cắt đoạn DII-DIII, nối tận-tận, cắt hang vị, DL mỏm tá tràng  3 BN (30%); Cắt đoạn DII-DIII-DIV, nối tân-tận, cắt hang vị, DL mỏm tá tràng 1 BN (10%); Cắt đoạn DIV, cắt đoạn ruột non, nối vị tràng 1 BN (10%); Khâu cầm máu, cắt hang vị, DL mỏm tá tràng 1 BN (10%); Nối vị tràng, nối mật ruột  1 BN (10%). Không có  tử vong (TV) trong, sau mổ và  ≤ 30 ngày. Không có BN mổ lại. Biến chứng rò 3 BN (1 BN sau cắt khối tá tụy, rò mật và tụy; 2 BN rò nhỏ sau cắt đoạn tá tràng  điều trị nội). Kết luận: Ung thư tá tràng hay các khối u tá tràng hiếm gặp (Tỷ lệ <1% với AC tá tràng, < 4-5% với GIST tá tràng). Triệu chứng thường gặp là đau bụng, xuất huyết tiêu hóa, hẹp tá tràng. Chụp CLVT và SANS có giá trị chẩn đoán cao các khối U tá tràng. + Đối với ung thư tá tràng AC, cắt đoạn tá tràng hay cắt khối tá tụy phụ thuộc vào vị trí U  cho kết quả (thời gian sống sau 5 năm) tương đương với điều kiện đạt được diên cắt R0. Giá trị tiên lượng quan trọng nhất là di căn hạch. + Đối với GIST tá tràng, phẫu thuật bao gồm cắt khối tá tụy (khối U DII  liên quan tới bóng Vater hoặc gây tắc mật), cắt đoạn tá tràng hay cắt tá tràng hình chêm. Phẫu thuật cắt khối tá tụy có tỷ lệ TV và biến chứng cao. Cắt đoạn tá tràng có thời gian sống thêm tương đương với cắt khối tá tụy nếu đạt được diện cắt R0 (1-2 cm cách), có tỷ lệ  biến chứng và TV giảm. + Các khối u cơ   (leiomyoma) nên chỉ định  nút mạch  (khi có XHTH), mổ cắt U khi BN ổn định.
ĐÁNH GIÁ CĂNG THẲNG LIÊN QUAN ĐÁI THÁO ĐƯỜNG VÀ CÁC YẾU TỐ LIÊN QUAN TRÊN BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÍP 2 CAO TUỔI
Authors: Võ Lê Quỳnh Như , Nguyễn Thanh Huân
Published: May 2024

Đặt vấn đề: Đánh giá tỉ lệ căng thẳng mức độ trung bình - nặng và các yếu tố liên quan trên bệnh nhân đái tháo đường típ 2 cao tuổi. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả thực hiện trên 161 bệnh nhân ≥60 tuổi mắc đái tháo đường típ 2 từ 3 tháng trở lên điều trị ngoại trú tại Phòng khám Nội tiết Bệnh viện Thống Nhất Thành phố Hồ Chí Minh từ tháng 10 năm 2023 đến cuối tháng 11 năm 2023. Đối tượng nghiên cứu được ghi nhận kết quả từ việc phỏng vấn bằng bộ câu hỏi đánh giá mức độ căng thẳng liên quan đái tháo đường Diabetes Distress Scale (DDS-17) cùng các yếu tố liên quan. Kết quả: Người cao tuổi mắc căng thẳng đái tháo đường mức độ trung bình - nặng thường có trình độ học vấn thấp dưới trung học phổ thông (35% so với 5%, p <0,001), thời gian bệnh dưới 5 năm năm thường mắc căng thẳng mức độ nặng hơn (31,8% so với 13,8%, p<0,001) và >10 năm sẽ có nguy cơ mắc căng thẳng mức độ trung bình (73,2% so với 45,5%, p<0,001). Ngoài ra, bệnh nhân dùng thuốc uống và tuân thủ dùng thuốc kém và khả năng kiểm soát đường huyết không tốt làm tăng khả năng bị căng thẳng (p<0,05). Về phương diện lão khoa, căng thẳng ít gặp ở nhóm bệnh nhân không suy yếu (79% so với 17%, p<0,001), không uống quá 5 loại thuốc mỗi ngày và không có hoặc ít bị trầm cảm lão khoa (p<0,05). Khi thực hiện hồi quy logistic đa biến, các yếu tố liên quan đến căng thẳng trên bệnh nhân đái tháo đường típ 2 cao tuổi là tăng huyết áp (OR 0,16; KTC 95% 0,03 – 0,99; p <0,05), bệnh võng mạc đái tháo đường (OR 269,74; KTC 95% 7,71 – 9431, 64; p <0,05), phương thức điều trị (OR 4,60; KTC 95% 1,46 – 14,89; p <0,05), việc tuân thủ dùng thuốc (OR 3,63; KTC 95% 1,30 – 10,16; p <0,05), mức độ kiểm soát đường huyết (OR 1,28; KTC 95% 0,34 – 4,79; p <0,05) và trầm cảm lão khoa (OR 16,76; KTC 95% 0,00 – 1544,85; p <0,05). Kết luận: Thời gian mắc bệnh, phương pháp điều trị, bệnh đồng mắc liên quan đái tháo đường, sự tuân thủ dùng thuốc và khả năng kiểm soát đường huyết, đa bệnh đa thuốc và trầm cảm lão khoa là những yếu tố làm tăng nguy cơ căng thẳng ở người cao tuổi. Căng thẳng đái tháo đường là một vấn đề cần được tầm soát đánh giá trong chăm sóc sức khoẻ của người cao tuổi và là mục tiêu chiến lược trong bảo vệ sức khoẻ tinh thần theo khuyến cáo của ADA 20241.
VAI TRÒ CỦA 18FDG- PET/CT TRONG CHẨN ĐOÁN GIAI ĐOẠN BỆNH UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ TẠI BỆNH VIỆN 19-8
Authors: Ngô Trọng Nguyên , Đỗ Thị Lệ Thúy , Trần Tất Hiến
Published: May 2024

Mục tiêu: Đánh giá giá trị của 18FDG - PET/CT trong chẩn đoán giai đoạn UTPKTBN. Đối tượng, phương pháp nghiên cứu: nghiên cứu tiến cứu trên 60 BN ung thư phổi không tế bào nhỏ (UTPKTBN) mới phát hiện, được chụp 18FDG PET/CT tại khoa chẩn đoán hình ảnh, Bệnh viện 19-8 từ 04/2021 - 08/2023. Kết quả: Chẩn đoán giai đoạn T giữa CLVT và PET/CT có sự tương đồng rất cao với hệ số kappa= 0,78. Chẩn đoán giai đoạn N và M giữa CLVT và PET/CT tương đồng yếu với hệ số kappa lần lượt là 0,38 và 0,26. Có 24 BN (40%) tăng giai đoạn sau chụp PET/CT. Kết luận: Chẩn đoán giai đoạn T giữa CLVT và PET/CT có sự tương đồng rất cao tuy nhiên chẩn đoán giai đoạn N và M giữa CLVT và PET/CT tương đồng yếu. 40% BN tăng giai đoạn sau chụp PET/CT.