bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S6 from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies
Authors: Chan Henry , Trout Christina V. , Mikolon David , Adams Preston , Guzman Roberto , Mavrommatis Konstantinos , Abbasian Mahan , Hadjivassiliou Haralambos , Dearth Lawrence , Fox Brian A. , Sivakumar Pallavur , Cho Ho , Hariharan Kandasamy
Published: February 2024

Pearson correlation coefficient (cc) of SIRPA expression vs each macrophage-related gene in each of the separate TCGA cohorts, sorted high to low based on the mean of the correlation coefficients
Supplementary Methods from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies
Authors: Chan Henry , Trout Christina V. , Mikolon David , Adams Preston , Guzman Roberto , Mavrommatis Konstantinos , Abbasian Mahan , Hadjivassiliou Haralambos , Dearth Lawrence , Fox Brian A. , Sivakumar Pallavur , Cho Ho , Hariharan Kandasamy
Published: February 2024

Preparation of BMS-986351
Supplementary Figure S2 from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies
Authors: Chan Henry , Trout Christina V. , Mikolon David , Adams Preston , Guzman Roberto , Mavrommatis Konstantinos , Abbasian Mahan , Hadjivassiliou Haralambos , Dearth Lawrence , Fox Brian A. , Sivakumar Pallavur , Cho Ho , Hariharan Kandasamy
Published: February 2024

Baseline CD47 expression by flow cytometry in colorectal cancer cell lines (A) and in DLBCL cell lines (B).
Teknologi Nontermal pada Pengolahan Pangan
Authors: Hawa La Choviya , Yulianingsih Rini , Putranto Angky Wahyu , Ali Dego Yusa
Published: February 2024

Buku ini memperkenalkan teknik pengolahan pangan terkini yang menggunakan prinsip tanpa pemanasan atau "nontermal" untuk meningkatkan kualitas produk pangan. Beberapa teknologi nontermal yang dijelaskan pada buku ini seperti pulsed electric field (PEF), ultrasonikasi, high hydrostatic pressure (HHP), gelombang mikro dan teknologi kriogenik. Setiap teknologi diulas secara lengkap meliputi dasar teori, prinsip kerja sistem, skema alat dan proses, serta menjelaskan kelebihan dan kekurangan proses yang dapat dijadikan acuan untuk penyempurnaan teknologi selanjutnya. Buku ini juga memberikan contoh dan studi kasus tentang aplikasi teknologi nontermal pada sektor pangan terutama pada produk susu, jus buah, bubur, irisan sayuran, ekstraksi, dan produk kering yang dirangkum baik dari hasil penelitian penulis maupun dari hasil penelitian dan referensi lainnya. Secara keseluruhan, buku ini dapat memberikan manfaat dan memberikan pengetahuan sistematis kepada semua kalangan seperti mahasiswa di tingkat sarjana, master dan doktoral, akademisi, tenaga ahli di bidang pangan dan agroindustri, para peneliti dan pembaca dari kalangan industri, serta pelaku bisnis pangan melalui beberapa contoh desain proses dan aplikasi teknologi nontermal untuk dijadikan sebagai referensi.
Tributo aos 120 anos da compositora e maestra Joanídia Sodré
Authors: Rosário Ana Claudia Trevisan
Published: February 2024

Nos 120 anos de nascimento de Joanídia Sodré, reaviva-se sua memória através de um breve relato de sua trajetória artística, seus pioneirismos e seu envolvimento junto ao movimento feminista brasileiro. Embora não tenha sido tão intensa sua participação, compôs o Hino Feminino ou Hino Feminista, em 1922, com letra da jornalista e poetisa Maria Eugênia Celso, participante muito ativa do mesmo movimento, homenageada, neste ano, por seus 60 anos de falecimento. Apresentarei uma breve biografia das autoras do hino, pontuando importantes momentos de suas trajetórias e destacando a influência de suas famílias, especificamente do pai e a precocidade de Sodré, dentre as compositoras brasileiras. Por último, contemplaremos uma análise mais aprofundada da composição, que se constituiu um dos símbolos da Federação Brasileira pelo Progresso Feminino.
Em harmonia com a natureza: recepção e estudo de "Under the greenwood tree" – uma canção de William Shakespeare para As You Like It (Como Gostais)
Authors: Zwilling Carin , Maciel Filho Leonel
Published: February 2024

Para a celebração dos 400 anos da edição do 1o Fólio de Shakespeare (1623) preparamos uma homenagem com a recepção e estudo de "Under the greenwood tree", uma canção de William Shakespeare para As You Like It, II.v. (Como Gostais), visando esclarecer a função da música na cena, sua motivação original, como se insere no diálogo protagonizado pelos personagens, transportando o público para o mundo dourado da floresta das Ardenas "onde não há inimigos a não ser o inverno e o mau tempo". (II.v.6–8) Para tanto, dividimos o artigo em várias camadas de comentários e, ao final, disponibilizamos a partitura composta para a canção por Thomas Augustine Arne, com o coro adicionado por William Linley ‒ o exemplo mais antigo encontrado, uma vez que a música original para esta canção se perdeu.
Semiquantitative 18F-FDG PET/CT in monitoring glucocorticoid response of immunoglobulin G4-related effusive constrictive pericarditis: a case report
Authors: An Soo Yeon , Sun Byung Joo
Published: February 2024

Background

Immunoglobulin G4 (IgG4)-related effusive constrictive pericarditis (ECP) is a rare manifestation of IgG4-related disease (IgG4-RD). It can lead to persistent pericardial fibrosis, resulting in cardiac tamponade, diastolic dysfunction, and heart failure. Glucocorticoids are the primary treatment for effectively reducing inflammation and preventing fibrosis. However, guidelines for monitoring treatment response are lacking and tapering glucocorticoid therapy for specific target organs remains a challenge. Recent studies on IgG4-RD have demonstrated that semiquantitative measurements of fluorine-18 fluorodeoxyglucose (18F-FDG) uptake in the main involved organs in positron emission tomography/computed tomography (PET/CT) scanning are correlated to disease activity. We present a case of IgG4-related ECP to demonstrate the usefulness of 18F-FDG PET/CT for diagnosing and treatment follow-up of IgG4-related ECP.

Case presentation

Herein, a 66-year-old woman diagnosed with IgG4-related ECP presented with breathlessness, leg swelling, rales, and fever. Laboratory tests revealed markedly elevated levels of C-reactive protein, and transthoracic echocardiography revealed constrictive physiology with effusion. High IgG4 levels suggested an immune-related pathogenesis, while viral and malignant causes were excluded. Subsequent pericardial biopsy revealed lymphocyte and plasma cell infiltration in the pericardium, confirming the diagnosis of IgG4-related ECP. 18F-FDG PET/CT revealed increased uptake of 18F-FDG in the pericardium, indicating isolated cardiac involvement of IgG4-RD. Treatment with prednisolone and colchicine led to a rapid improvement in the patient’s condition within a few weeks. Follow-up imaging with 18F-FDG PET/CT after 3 months revealed reduced inflammation and improved constrictive physiology on echocardiography, leading to successful tapering of the prednisolone dose and discontinuation of colchicine.

Conclusion

The rarity of IgG4-related ECP and possibility of multiorgan involvement in IgG4-RD necessitates a comprehensive diagnostic approach and personalized management. This case report highlights the usefulness of 18F-FDG PET/CT in the diagnosis and treatment follow-up of isolated pericardial involvement in IgG4-RD.
Scoping review on the role of the family doctor in the prevention and care of patients with foetal alcohol spectrum disorder
Authors: Leruste Sébastien , Doray Bérénice , Maillard Thierry , Lebon Christophe , Marimoutou Catherine , Spodenkiewicz Michel
Published: February 2024

Background

Foetal alcohol spectrum disorder (FASD) is the leading preventable cause of nongenetic mental disability. Given the patient care pathway, the General Practitioner (GP) is in the front line of prevention and identification of FASD. Acknowledging the importance of the prevalence of FASD, general practitioners are in the front line both for the detection and diagnosis of FASD and for the message of prevention to women of childbearing age as well as for the follow-up.

Objectives

The main objective of the scoping review was to propose a reference for interventions that can be implemented by a GP with women of childbearing age, their partners and patients with FASD. The final aim of this review is to contribute to the improvement of knowledge and quality of care of patients with FASD.

Methods

A scoping review was performed using databases of peer-reviewed articles following PRISMA guidelines. The search strategy was based on the selection and consultation of articles on five digital resources. The advanced search of these publications was established using the keywords for different variations of FASD: "fetal alcohol syndrome," "fetal alcohol spectrum disorder," "general medicine," "primary care," "primary care"; searched in French and English.

Results

Twenty-three articles meeting the search criteria were selected. The interventions of GPs in the management of patients with FASD are multiple: prevention, identification, diagnosis, follow-up, education, and the role of coordinator for patients, their families, and pregnant women and their partners. FASD seems still underdiagnosed.

Conclusion

The interventions of GPs in the management of patients with FASD are comprehensive: prevention, identification, diagnosis, follow-up, education, and the role of coordinator for patients, their families, and pregnant women and their partners.

Prevention interventions would decrease the incidence of FASD, thereby reducing the incidence of mental retardation, developmental delays, and social, educational and legal issues.

A further study with a cluster randomized trial with a group of primary care practitioners trained in screening for alcohol use during pregnancy would be useful to measure the impact of training on the alcohol use of women of childbearing age and on the clinical status of their children.
Association of personal and systemic factors on intrapartum risk perception and obstetric intervention rates: a cross-sectional study
Authors: Peterwerth Nina H , Halek Margareta , Schäfers Rainhild
Published: February 2024

Background

Risk perception is fundamental to decision-making; therefore its exploration is essential to gaining a comprehensive understanding of the decision-making process for peripartum interventions. The aim of this study was to investigate associations between personal and systemic factors of the work setting and the risk perception of obstetric healthcare professionals, and in turn how this might influence decisions regarding obstetric interventions.

Methods

Case vignettes were used to measure risk perception. A quantitative cross-sectional online survey was performed within an exploratory sequential mixed-methods design, and an intervention readiness score created. Associations were calculated using location and dispersion measures, t-tests and correlations in addition to multiple linear regression.

Results

Risk perception, as measured by the risk assessment score, was significantly lower (average 0.8 points) for midwives than for obstetricians (95%-CI [-0.673; -0.317], p < .001). Statistically significant correlations were found for: years of experience and annual number of births in the current workplace, but this was not clinically relevant; hours worked, with the groups of participants working ≥ 30,5 h showing a statistically significant higher risk perception than participants working 20,5–30 h (p = .005); and level of care of the current workplace, with the groups of participants working in a birth clinic (Level IV) showing a statistically significant lower risk perception than participants working in Level I hospital (highly specialised obstetric and neonatal care; p = .016). The option of midwife-led birthing care showed no correlation with risk perception. The survey identified that risk perception, occupation, years in the profession and number of hours worked (i.e. full or part time) represent significant influences on obstetric healthcare professionals’ willingness to intervene.

Conclusions

The results of the survey give rise to the hypothesis that the personal and systemic factors of professional qualification, occupation, number of hours worked and level of acuity of the workplace are related to the risk perception of obstetric healthcare professionals. In turn, risk perception itself made a significant contribution to explaining differences in willingness to intervene, suggesting that it influences obstetricians’ and midwives’ decision-making. Overall, however, the correlations were weak and should be interpreted cautiously. The significant variations in the use of interventions must be addressed in order to provide the highest quality and best possible care for childbearing women and their families. To this end, developing strategies to improve interdisciplinary relationships and collaboration is of great importance.

Trial registration

German Clinical Trials Register DRKS00017172 (18.06.2019).
A nomogram for predicting adverse pathologic features in low-risk papillary thyroid microcarcinoma
Authors: Gong Lei , Li Ping , Liu Jingjing , Liu Yan , Guo Xinghong , Liang Weili , Lv Bin , Su Peng , Liang Kai
Published: February 2024

Background

Identifying risk factors for adverse pathologic features in low-risk papillary thyroid microcarcinoma (PTMC) can provide valuable insights into the necessity of surgical or non-surgical treatment. This study aims to develop a nomogram for predicting the probability of adverse pathologic features in low-risk PTMC patients.

Methods

A total of 662 patients with low-risk PTMC who underwent thyroid surgery were retrospectively analyzed in Qilu Hospital of Shandong University from May 2019 to December 2021. Logistic regression analysis was used to determine the risk factors for adverse pathologic features, and a nomogram was constructed based on these factors.

Results

Most PTMC patients with these adverse pathologic features had tumor diameters greater than 0.6 cm (p < 0.05). Other factors (age, gender, family history of thyroid cancer, history of autoimmune thyroiditis, and BRAFV600E mutation) had no significant correlation with adverse pathologic features (p > 0.05 each). The nomogram was drawn to provide a quantitative and convenient tool for predicting the risk of adverse pathologic features based on age, gender, family history of thyroid cancer, autoimmune thyroiditis, tumor size, and BRAFV600E mutation in low-risk PTMC patients. The areas under curves (AUC) were 0.645 (95% CI 0.580–0.702). Additionally, decision curve analysis (DCA) and calibration curves were used to evaluate the clinical benefits of this nomogram, presenting a high net benefit.

Conclusion

Tumor size > 0.60 cm was identified as an independent risk factor for adverse pathologic features in low-risk PTMC patients. The nomogram had a high predictive value and consistency based on these factors.
Dra. territorios en disputa: ¿la autogestión de hábitat como estrategia de reapropiación de comunes urbanos?.
Authors: Cecilia Zapata María
Published: February 2024

El proceso de hipermercantilización que impone la reestructuración capitalista de los ‘70 encuentra en las ciudades posibilidades predilectas para la acumulación inmobiliaria y, por ende, la desposesión de amplios sectores sociales. Este escenario, en la Ciudad de Buenos Aires (Argentina), generó brechas para la emergencia de experiencias de producción autogestionaria de hábitat con capacidad de reapropiación de comunes urbanos que implicaron una disputa concreta en materia productiva, comunitaria y cultural. Desde una metodología cualitativa basada en la teoría fundamentada y a partir de la identificación de dimensiones específicas de análisis, en este artículo se reflexiona sobre las disputas materiales y simbólicas existentes en torno a la práctica autogestionaria en las experiencias habitadas del Programa de Autogestión de la Vivienda. Se demuestra que sólo algunos proyectos se imbricaron en prácticas concretas de autogestión de hábitat disputando la reapropiación de comunes urbanos, en detrimento de un conjunto de experi
Clinical negligence: should the NHS consider a no-fault system?
Authors: Tingle John
Published: February 2024

John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, considers recent discussions and recommendations to review the current compensation scheme
Spaces of Estrangement in Luiz Ruffato's Eles Eram Muitos Cavalos
Authors: Beal Sophia
Published: February 2024

Abstract: In 2001, Luiz Ruffato published Eles eram muitos cavalos , one of the most celebrated Brazilian novels of the last thirty years. That same year, the renowned geographer Ana Fani Alessandri Carlos—who has dedicated most of her career to studying São Paulo— published the article "São Paulo hoje: as contradições no processo de reprodução do espaço." Ruffato's and Carlos's texts render a moment just prior to widespread access to the internet and social media that transformed spatial practices, communication, activism, and consumption within global cities. I return to Ruffato's novel over two decades after its initial publication to analyze how it—in ways that dovetail with contemporary Brazilian urban geography— envisions the right to the global city, particularly residents' experience of estrangement. Both Ruffato and Carlos capture the ways that the dominance of the capitalist production of space creates estrangement because residents are disconnected from a social fabric, fearful of the street, and less able to create collective urban memories. As Carlos spatially explains the production of estrangement in São Paulo, Ruffato, employing innovative aesthetic solutions, imagines how individuals experience estrangement in the city. The novel, despite its local specification, conveys, more broadly, residents' sensory and emotional experiences of estrangement in global cities.
Association of Dietary Inflammatory Index with CKD progression and estimated glomerular filtration rate in the American CKD population: A cross-sectional study
Authors: Xu Zichen , Li Lei , Jiang Luqing , Zhai Ying , Tang Yu , Liu Daoqin , Wu Qiwen
Published: February 2024

Purpose

The number of CKD patients is on the rise worldwide, and diet has become an essential aspect influencing the treatment and prognosis of CKD. However, limited research has explored the association of the Dietary Inflammatory Index (DII) with CKD progression and the essential kidney function indicator, eGFR, in CKD patients. This study aimed to analyze the association between DII and CKD progression and eGFR in the US CKD population using data from the National Health and Nutrition Examination Survey (NHANES).

Methods

This study utilized data obtained from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018, with a total sample size of 2,488 individuals. Study used multiple imputation, based on 5 replications and a chained equation approach method in the R MI procedure, to account for missing data. Weighted multiple logistic regression was used to analyze the relationship between DII and the risk of higher CKD stage and a weighted multiple regression analysis was used to assess the relationship between DII and eGFR. Weighted Generalized Additive Models and smoothed curve fitting were applied to detect potential non-linear relationships in this association.

Results

In all three models, it was found that DII was positively associated with the risk of higher CKD stage (P < 0.0001), and an increase in DII was associated with a decrease in eGFR (P < 0.0001). The trend across quartiles of DII remained statistically significant, revealing a gradual elevation in higher CKD stage risk and reduction in eGFR levels for the second, third, and fourth quartiles compared to the lowest quartile (P for trend < 0.0001). Upon adjusting for age, gender, race, education level, poverty income ratio (PIR), marital status, body mass index (BMI), metabolic equivalent (MET) score, drinking, smoking, history of hypertension, history of diabetes, cotinine, systolic blood pressure, diastolic blood pressure, total triglycerides, and total cholesterol, we found a positive correlation between DII and the risk of higher CKD stage (OR = 1.26, 95% CI: 1.14–1.40). Further investigation revealed that an increase in DII was associated with a decrease in eGFR (β = -1.29, 95% CI: -1.75, -0.83). Smooth curves illustrated a non-linear positive correlation between DII and CKD risk, while a non-linear negative correlation was observed between DII and eGFR.

Conclusions

Our study results indicate that an increase in DII is associated with an increased risk of higher CKD stage and a decrease in eGFR in all three models. In the fully adjusted model, the risk of higher CKD stage increased by 26% and the eGFR decreased by 1.29 ml/min/1.73 m2 for each unit increase in DII. This finding suggests that in patients with CKD in the US, improved diet and lower DII values may help slow the decline in eGFR and delay the progression of CKD.
The return of Place: When local media collaborates with public libraries
Authors: Edwardsson Malin Picha , Zuiderveld Maria
Published: February 2024

Generally speaking, public libraries and local media are quite different, but at the same time, they share similarities when it comes to promoting local democratic processes. So, what happens when they collaborate with a common goal? What are their actual similarities and differences? Can they collaborate in order to strengthen each other? How does this collaboration relate to the scientific discussion about public space and place, participatory journalism and civic engagement? These are some of the questions explored in this article. Our research draws empirically on semi-structured interviews with Swedish journalists and librarians in an unusual project with the aim to explore how new forms of collaboration between libraries and local newspapers could strengthen the information and media literacy leading up to the general elections in September 2022. The collaboration resulted in an increased awareness about the importance of place, as local media companies discovered how important place is for connecting with their readers. Furthermore, we draw the conclusion that both local media companies and public libraries could be more active when creating an arena for democratic discussions since there is great potential for more collaboration in the future. Even though they face different conditions, Swedish media could continue to explore this particular road to increased relevance in order to enhance civic engagement.
liberdade de expressão
Authors: Dantas Júnior João Fabrício
Published: February 2024

A liberdade de expressão, consagrada à Constituição e ainda em documentos de Direito Internacional sobre direitos humanos, é uma das principais facetas de um regime democrático. Por outro lado, como todo direito, há limitações. O discurso de ódio, assim, tematicamente mostra-se desafiador a aqueles que pregam uma suposta liberdade plena de ideias. Os tempos de comunicação de massa, potencializados por perfis de redes sociais que alcançam uma grande quantidade de seguidores, no Brasil, podem ser momentos desafiantes para as balizas legais da expressão de ideias. A manifestação de pensamento, seu abuso ou, ainda, a completa inadequação constitucional do discurso de ódio, pedem um aprofundamento, que beberá ainda de balizas entregues pelo Direito Internacional e, também, do quanto o sistema jurídico permitiria um controle antecipado de tal conteúdo sob as balizas da proibição da censura, como prevê a própria Constituição. A liberdade de expressão, assim, poderia encontrar limites temáticos que se mostrariam diferentes em diferentes democracias. O quadro brasileiro demanda este aprofundamento.
Dignidade da pessoa humana e criminalização:
Authors: Kelner Lenice , Knaesel Arrabal Alejandro , Analú Marcolla Fernanda
Published: February 2024

Este artigo tem por intuito analisar a possibilidade de inserção no ordenamento jurídico brasileiro da castração química como pena para os crimes sexuais, frente ao princípio da dignidade da pessoa humana. O estudo oferece um panorama comparativo da aplicação dessa medida nos Estados Unidos da América e da Espanha, partindo de informações estatísticas e resultados de cada país quanto a efetividade de tal prática na diminuição da reincidência dos crimes sexuais. Destaca-se que, assim como no Brasil, todos os países que tentaram ou implantaram a pena de castração química para os crimes sexuais precisaram analisar a pena sob a ótica constitucional, principalmente no que tange a dignidade da pessoa humana e a vedação das penas cruéis. Enquanto os Estados Unidos da América adotaram legalmente a castração química sob o argumento que representa um tratamento clínico (e não uma pena), a Espanha e o Brasil, em contrapartida, reconhecem que a medida caracteriza uma afronta aos direitos humanos, o que resulta em sua inconstitucionalidade. Em que pese haver projetos de lei que versem sobre essa matéria desde o ano de 1997, todos os projetos foram arquivados por afrontar os princípios norteadores da Constituição Federal de 1988.
Gräberfelder der Czarna Hańcza Gruppe. Die Bestattungsbräuche der alten Sudauer
Authors: Jończyk Ludwika
Published: February 2024

Dieser Beitrag ist den Bestattungsbräuchen in der Zeit vom Ende des 9. bis zum 13. Jh. in dem Gebiet gewidmet, das historisch mit dem Stamm der Sudauer (Jaćwingowie) verbunden ist. Auf einer Übersichtskarte, die die frühmittelalterliche Besiedlung auf preußischem Gebiet darstellt, ist eine Ansammlung von Fundstellen hervorgehoben, die als Czarna Hańcza Gruppe bezeichnet wird. Innerhalb dieses Komplexes wurden bisher 16 Gräberfelder entdeckt. Deren Analyse ergab, dass im Laufe von mehr als 150 Jahren Forscher aus verschiedenen Ländern ähnliche Nekropolen entdeckt haben. Sie befanden sich auf dem Staatsgebiet mehrerer Länder (zuerst Russland und Ostpreußen, dann Polen und Litauen) und wurden in den meisten Fällen stichprobenartig untersucht und nie zusammengeführt.

Es handelt sich um flache Brandgräberfelder. In einigen von ihnen wurden sehr flache und ausgedehnte Gruben beobachtet, in den Konzentrationen von verbrannten Knochen und Ausrüstung beobachtet wurden, osteologisches und archäologisches Material aber auch verstreut in den ganzen Gruben zu finden war. In anderen Fällen konnten nur erhebliche Mengen von verbrannten menschlichen Knochen und mitunter sehr reiche Ausrüstungsbeigaben in der Oberflächenschicht festgestellt werden.

Die Ausstattung weist sehr oft Spuren von vorsätzlicher Zerstörung (Schneiden, Biegen, Brechen) und Verbrennung auf dem Scheiterhaufen auf. Eine Übersicht, die Tausende von Fundfragmenten, die bisher aus der Czarna Hańcza Gruppe bekannt sind einbezieht, ermöglichte es, die Leitfunde für diese Region zu definieren.
Penyusunan Instrumen Maturity Assessment Design Toolkit Berbasis COBIT 2019
Authors: Indrawati Anna Retno , Rozas Indri Sudanawati , Wahyudi Noor
Published: February 2024

Penerapan teknologi informasi dalam organisasi selain disamping membutuhkan investasi yang besar juga mempunyai risiko yang tinggi sehingga membutuhkan pengawasan secara menyeluruh, oleh karena itu diperlukan tata kelola TI dan audit agar berjalan sesuai tujuan. Audit teknologi informasi dilakukan menggunakan framework, salah satunya yaitu COBIT 2019 yang merupakan versi terbaru dari COBIT. Audit TI dilakukan dengan tujuan menemukan dan memperbaiki gap antara keadaan dan tujuan organisasi. Untuk menemukan gap perlu dilakukan penilaian maturity. Dalam COBIT 2019 untuk mendapatkan nilai maturity diperlukan nilai capability dari tujuh komponen yang ada, namun COBIT 2019 hanya terdapat panduan penilaian capability untuk komponen proses belum beserta enam komponen lainnya. Penelitian ini bertujuan untuk mengembangkan maturity assessment design toolkit yang sesuai dengan framework COBIT 2019. Metode yang digunakan dalam penelitian ini adalah Research and Development (RnD) level 1 Sugiyono yang disesuaikan dengan kebutuhan penelitian. Hasil penelitian menunjukkan bahwa proses desain produk dilakukan dalam enam tahapan yaitu identifikasi proses, identifikasi komponen, identifikasi aktivitas, identifikasi capability, desain perhitungan nilai capability, dan desain perhitungan nilai maturity.
Penerapan Deep Learning Untuk Klasifikasi Kesegaran Daging Sapi Berbasis Mobile Apps
Authors: Ekamila Teris , Rahayu Fajar , Zuchriadi Achmad , Octa Indarso Andhika
Published: February 2024

Tingginya konsumsi daging sapi di Indonesia membuat kebutuhan daging sapi di Indonesia selalu naik secara signifikan setiap tahun. Hal ini berbanding terbalik dengan produksi daging sapi di Indonesia yang menyebabkan impor dan harga daging sapi terus melonjak naik. Keadaan ini membuat pedagang daging sapi melakukan kecurangan mencampur daging sapi segar dengan tidak segar. Untuk mengatasi masalah tersebut, dibutuhkan suatu sistem untuk mengklasifikasi dan  mendeteksi kesegaran daging sapi sesuai karakteristik yang dimilikinya. Salah satu metode deep learning yang banyak digunakan saat ini yaitu Convolutional Neural Network (CNN). Pada CNN, citra diolah menjadi sebuah model yang mampu mengklasifikasikan kelas pada kesegaran daging sapi. Model klasifikasi terbaik pada penelitian ini yaitu akurasi  sebesar 100% pada data latih dan data uji, nilai loss sebesar 0,0233 dengan learning rate, epoch dan optimizer ADAM untuk meningkatkan tingkat akurasi pada model. Implementasi model pada mobile apps berbasis Android yang dapat digunakan untuk mendeteksi tingkat kesegaran daging sapi.
Endangerment: foreign experience and realities of martial law in Ukraine
Authors: Kozych I.V.
Published: February 2024

In this article, from the point of view of a comparative analysis, the legal provisions of the criminal legislation of some foreign countries, dedicated to the regulation of criminal liability for endangerment, are considered. The characteristic features of the method of normative display of the features of the crime, the use of different approaches to the differentiation of criminal liability are analyzed. The need for the implementation of certain provisions in the process of implementing the domestic criminal law policy has been defined and substantiated.In particular, Part 3 of Article 135 of the Criminal Code of Ukraine provides for responsibility for "Actions provided for in Parts One or Two of this Article, if they caused the death of a person or other grave consequences." In foreign countries, committing such acts may require other qualifications. In particular, if a person left another person in danger with the intention of encroaching on his life, then in such cases the culprit is punished as for intentional murder. In some countries, there is liability for holding another person from providing assistance or hindering it. There is also differentiation in the age of the injured person, which can lead to the definition of a different list of persons who are obliged or should provide assistance to them. In addition to the specified opportunities for improving the current criminal legislation, the peculiarities of the application of the specified norm under martial law were considered.
The issue of Abkhazia and South Ossetia in Georgian-russian interstate relations
Authors: Adamovych S.V. , Adamovych I.S.
Published: February 2024

In this article the authors explore historical and legal grounds of separatist tendencies in South Ossetia and Abkhazia, the role of russia in stirring up the confrontation of autonomies with Georgia and influence of these processes on Georgian-russian interstate relations. In the authors’s opinion separatist tendencies in South Ossetia and Abkhazia are of a long-term nature and were shaping through Soviet national policy, the federal system of the USSR, lack of centralized power in Georgia during the period of disintegration of the USSR, dissatisfaction of regions because of Georgia implementing ethnonational policy, active participation of russia in inciting separatist movements. Over the years, russia has actually interfered in the internal politics of Georgia, explaining this with the concept of «special responsibility». russia’s policy was carried out under the guise of neutrality and peacemaking, which helped for a certain period of time to convince the international community that russia was trying to resolve the conflict.The rapprochement policy and creation of a system of agreements with self-proclaimed republics is part of Russia’s plan to maintain influence in the South Caucasus region, create obstacles for Georgia on its way to Euro-Atlantic integration, and prevent any US advance in the region. Prospects for conflict resolution in the short term are insignificant, since it is beneficial for russia to delay the frozen state as long as possible. On the other hand, Georgia is unable to solve the issue of the return of Abkhazian and Ossetian autonomies on its own without sufficient military power, economic potential and the support of Western allies, who currently have a war in Ukraine on their agenda. Therefore, the most likely development of events in the region is strategic patience, which over time will most likely benefit only one side of the conflict.
The content and scope of the concept of «corruption criminal offense» in the criminal law of Ukraine
Authors: Lyashchenko V.L.
Published: February 2024

The article states that both in the doctrine of criminal law and in law enforcement practice, there are still unresolved problems related to the content and scope of the concept of «corruption criminal offense». After the introduction of the concept of corruption crime into the Criminal Code of Ukraine in the footnote to Art. 45 of the Criminal Code of Ukraine, scientific discussions have changed their emphasis on the analysis of the validity of the definition of the relevant concept in the form of an exhaustive list of crimes belonging to the elements of corruption; concentrated on the list itself, defined by the legislator, on its addition or, on the contrary, reduction. The purpose of this article was to generalize scientific positions regarding the content and scope of the concept of corruption criminal offense and to define on this basis the author’s definition of the corresponding concept.It has been established that the main vectors to which the scientific results of the studies covered in the special literature are aimed are three: 1) addition, expansion of the list defined in the footnote to Art. 45 of the list of corruption criminal offenses; 2) reduction, narrowing of such a list. The list of corruption criminal offenses, and it acts in this case as the scope of the concept of «corruption criminal offense», directly depends on the content of this concept. In this context, attempts to define the concept of corruption criminal offense using a certain set of features that characterize the two concepts that meaningfully make it up: «corruption» and «criminal offense» seem productive. Both of these concepts are normatively defined: the Law of Ukraine «On Prevention of Corruption» and Art. 11 of the Criminal Code of Ukraine contain relevant definitions.The article proposes to leave in the definition a list of «unconditionally corrupt» criminal offenses, the constitutive features of which are signs of corruption offenses: abuse of official position in the broad sense and the presence of unlawful gain as the purpose, object or means of committing the offense. Article should be excluded from the current version of such a list. 210 of the Criminal Code of Ukraine. However, this will not mean that an act that falls under this criminal law prohibition cannot be corrupt. It should be considered in the context of the second group of encroachments - corruption «under condition». When formulating the definition of this group, it seems worth abandoning an exhaustive list, indicating in the normative provision the signs of the actual composition of the encroachment.
Odontoglossum crispum: a tale of love, loss and scientific discovery
Authors: Seaton Philip T.
Published: February 2024

This is the story of Odontoglossum crispum (Oncidium alexandrae), from the 19th century to the present day. It is a love story because Odontoglossum crispum was considered by many to be the most beautiful of all orchid species. It was collected by the hundreds of thousands from the cloud forests of its native Colombia and exported to Britain, the rest of Europe and the USA. Vast numbers were lost in transit. When they arrived many perished due to a lack of understanding of its needs in cultivation. Only the ‘best’ forms were grown, and the remainder discarded. Today much of its native habitat has either disappeared or been despoiled due to human actions. Few plants remain in cultivation in the UK. It was one of the first species to be grown commercially from seed, most notably in the UK by Charlesworth & Co., following the scientific discovery by Noël Bernard that orchid seeds required the participation of a suitable fungus to germinate under natural conditions.
Selection of equipment for experimental studies of the stress-strain state of reinforced soil bases and pavement structures
Authors: Kleveko V. I. , Teterin E. I.
Published: February 2024

Reinforced soil structures are often used in the practice of transport and industrial construction. The existing methods for calculating such structures have a number of significant drawbacks and do not always allow to accurately determine the design parameters, especially for settlement and tensile stresses in the reinforcing layers. To improve the methods for calculating reinforced soil structures, it is necessary to conduct full-scale experiments to determine their stress-strain state. Field experiments to assess the stress-strain state of reinforced soil structures are a complex technical problem. Most often, in these full-scale experiments, round stamps of various diameters are used. In the course of research, it is necessary to measure normal stresses and vertical displacements in the core of the reinforced soil base and tensile stresses in the reinforcing layers. To improve the accuracy of measurements and reduce the distortions that sensors introduce into the stress-strain state of reinforced soil structures, their careful selection is necessary for a number of parameters. The paper provides recommendations on the selection of pressure sensors for measuring vertical normal stresses in the soil mass. The diameter of the pressure sensors should not exceed 28-80 mm, depending on the diameter of the round die used for testing, and the recommended thickness of the pressure sensors should not exceed 2.8-8.0 mm. After the selection of pressure sensors, it is necessary to determine the measuring strain gauge system. The main criteria for selecting a measuring strain gauge system are the number of active strain gauges in each pressure sensor, the total number of measurement channels, and the electrical resistance of strain gauges. To measure tensile stresses in the reinforcing layers, you can use miniature strain gauge sensors using bridge or half-bridge connection schemes for active strain gauges.
Heat treatment of ground surface using an electric arc plasma generator
Authors: Sirotyuk V. V.
Published: February 2024

The article presents a generalization of the results of experimental and theoretical studies on the intensive thermal effect on the surface of foundations from cohesive soils (as opposed to deep heat treatment) using an electric arc generator of low-temperature plasma (plasmatron). A plasmatron with massive consumable electrodes made of borosilicated graphite and a wide "blurred" plasma torch was used for heat treatment. Physical and mathematical modeling of the thermal effect on the surface of clay soil by a moving high-temperature source has been performed. For the first time, a special installation was manufactured and experimental studies were carried out on the heat treatment of ground surfaces on the site with an electric arc plasma torch. It is established that the effective heat flux density reaches 2.5-.3.5 kW/cm2. The main part of the thermal energy for the used plasmatron enters the material due to radiant heat transfer. An analytical mathematical model of the temperature field of a three-dimensional semi-bounded body in the technological process under consideration is given by an essentially nonlinear boundary value problem for a nonlinear heat equation with nonlinear boundary conditions of the second kind. When solving thermophysical problems, the ground semi-bounded space was considered as a quasi-homogeneous medium having a constant initial temperature and initial thermophysical parameters that change in the process of temperature increase. The effective values of the thermophysical characteristics were determined on the basis of experimental data. Calculations and experiments have shown that the temperature boundary leading to significant changes in the structural properties of soils drops to a depth of 4-6 cm from the surface, despite the boiling of the ground melt with a temperature of 2500 ...2800 K on the ground surface. Therefore, a new technological principle of heat treatment is proposed, which consists in building up the ground melt in layers of 4-5 cm up from the initial surface. The impossibility of obtaining a positive effect even with the use of a powerful high-temperature source of exposure in the case of traditional surface heat treatment technology has been confirmed. The new plasma technology of surface heat treatment of ground surfaces to the stage of silicate melt allows to obtain a common layer of the required thickness. At the same time, the efficiency of surface heat treatment is significantly increased. The new technology of layer-by-layer surface deposition reduces cracking in the layer when the melt cools, but does not eliminate this negative process.
Dual-channel call center model with exchange of requests and repeat calls
Authors: Barkalov S. A. , Serebryakova E. A.
Published: February 2024

Computer simulation of stationary distribution of states in a call center for a two-channel RQ system with exchange of requests is presented. Such systems are becoming increasingly relevant due to the parallel use of both human dispatchers and voice intelligent bots for servicing calls. The simulation is based on solving the system of stationary Chapman-Kolmogorov equations for the Markov process describing the RQ-system. The system of equations proposed in the work differs from previous models by the presence of an exchange of requests between service channels in accordance with customer preferences. It takes into account the possibility of random repeated calls within a given average time. Service time in channels and delay time of requests in orbits have exponential distribution laws. Requests in orbit have the property of impatience, i.e. leave the system after some random time. To find the stationary distribution of states in orbits, the iterative numerical Gauss-Seidel method is used, which ensures fast convergence of calculations. Each channel has its own orbit of requests. The accuracy of the solution is controlled by increasing the maximum number of requests in orbit until the result stabilizes. The model demonstrates the sensitivity of system performance to the asymmetry of customer preferences when changing channels. Numerical simulation was carried out for the call center of the housing management company "StroyTekhnika" in the city of Voronezh. Application flows and repeat call parameters were calculated based on data from the company website and social network analysis. Accounting for repeat calls reduces system throughput compared to the option of completely impatient customers who do not use repeat calls. The case of completely impatient customers describes the limit state of a service system. At the same time, redistributing calls in favor of a more productive channel improves the overall performance of the system. The results obtained show the feasibility of using high-performance multi-channel voice bots while simultaneously stimulating a shift in customer preferences in favor of intelligent automata.
The seahills and seahills ecosystems in the nearshore of Thua Thien-Hue province (Central Vietnam)
Authors: Bui Van Vuong , Nguyen Van Quan , Nguyen Dac Ve , Nguyen Duc The , Tran Thi Thu Trang , Pham Van Chien , Nguyen Thi Kim Anh , Dang Hoai Nhon , Nguyen Thi Mai Luu , Hoang Thi Chien , Le Van Nam , Dinh Hai Ngoc , Tran Huu Long , Le Dinh Nam , Phan Dong Pha , Vu Le Phuong
Published: February 2024

At the seabed in the nearshore, Vietnam has sandbars, shoals, bedrock knobs, rock reefs, and other landforms with elevations a few to several tens of meters higher than the seabed, which is always under the lowest astronomical tide (chart datum) and material structure of diverse compositions such as sands, gravel, boulders, blocks, etc. They have determined and warned on the chart map for the safety of navigation and the navy. These areas are significant fishing grounds due to abundant fish, shrimp, and benthic organisms. However, until now, investigation, research, and knowledge regarding these landforms’ environment, biomes, and naturals have yet to be explored. This paper presents some initial results of natural features (morphology, genetic terrain, material compositions, and types), environmental features, ecological community features (diversity, major groups of organisms, marine fish resources), and their significance in marine biomes (distribution of organisms, ecological linkage, habitats of endemic species) of a sandbar, bedrock in the nearshore in Thuan An, Tu Hien - Chan May and Lang Co - Hai Van - Son Cha of Thua Thien Hue province in the framework project of Thua Thien Hue province and National Independent Project belongs to the National Program 562 with Code Number is ĐTĐLCN.78/22. Based on these findings, the authors proposed naming this terrain “seahill” and the accompanying ecosystem “seahill ecosystems” in the nearshore of Vietnam while continuing to investigation, survey, and research.
Civil liability for damages caused by doctors without specialization
Authors: Boratyńska Maria
Published: February 2024

As is well known, the determinant and premise of a doctor’s civil and professional liability is compliance or failure to exercise due diligence. Theoretically, doctors are subject to uniform measures of diligence in the sense that, for the circumstances of a specific case, an objective standard of compliance is established, which is required of the doctor in front of the patient, without thinking about where and how a particular doctor should try it out in advance. Meanwhile, not all doctors are equally skilled. Passing the exam and the obtained medical diploma are just the beginning. You must first complete a postgraduate internship, and then usually also a specialization, which may last as long as medical studies. The Act on the Professions of Doctor and Dentist restricts the professional rights of trainees and specialists (brief description here). Nevertheless, it is commonly known that specialists are regularly appointed to be on duty independently. Against this background, the question arises to what extent such a way of organizing work is correct from the point of view of the patient's right to healthcare services provided with due diligence, and how is the responsibility of medical entities and doctors themselves presented for faults committed in such conditions. In particular – how to assess the fault of an insufficiently skilled specialist or trainee and how to plan the proper organization of medical care over a patient, taking into account the obvious need to educate doctors also through surgical practice on a living organism. Moreover, what are the duties of a professionally dependent physician in such circumstances? The considerations will be illustrated with practice cases and court judgments.