bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultural identity and glocalization—A case study of Thai restaurants in Kunming
Authors: Yin Zhouyan , Ardsmiti Narong
Published: August 2024

This article focuses on Thai restaurants in Kunming and discusses whether Thai food is adapted to the local taste. It also investigates the values and meaning of Thai food for different consumer groups. The study adopts an ethnographic approach and uses fieldwork and participant observation to examine the complex processes of cultural adaptation, culinary negotiations, and the formation of cultural bonds within this gastronomic landscape. This study reveals the multifaceted facets of Thai cuisine, encompassing ecological dimensions, distinctive gastronomic practices, and cultural customs rooted in Thailand. It explores the transnational mobility of Thai cuisine, tracing its journey across borders and its subsequent glocalization in Kunming's culinary milieu. The study looks at the nuanced strategies deployed by Thai culinary practitioners to integrate authentic Thai ingredients while simultaneously responding to local tastes and preferences. An important aspect of this study is to examine the diverse spectrum of diners visiting Thai restaurants in Kunming. By analyzing the different perceptions and culinary preferences of Chinese and Thai diners, the study unravels the complex ways in which Thai cuisine negotiates authenticity and local resonance. The delicate balance between authenticity and glocalization is proving to be a key strategy for Thai restaurants to maintain their uniqueness while gaining local acceptance. In conclusion, this ethnography sheds light on the vibrant tapestry of cultural identity and glocalization in the context of Thai restaurants in Kunming. Through an in-depth examination of the interaction between Thai cuisine, the community, and the local environment, this study contributes a deeper insight into the intricately complex dynamics that shape the culinary landscape and cultural interactions in Kunming.
MAGNITUDE OF PREMARITAL SEXUAL PRACTICE AND ASSOCIATED FACTORS AMONG ADIGRAT HIGH SCHOOL STUDENTS, ETHIOPIA, A CROSS SECTIONAL STUDY
Authors: Beyene Kasahun , Hinkosa Leta , Bekele Daniel , Demtsu Balem
Published: August 2024

ABSTRACTINTRODUCTION: Premarital sexual practice is sexual intercourse experienced before marriage. It usually leads to sexual and reproductive health problems that are the main causes of death, disability and disease among young people in the world particularly in Africa including Ethiopia. OBJECTIVE: To assess the magnitude of premarital sexual practice and associated factors among Adigrat high school students, Ethiopia, 2015. OBJECTIVE: To assess the magnitude of premarital sexual practice and associated factors among Adigrat high school students, Ethiopia, 2015. METHODS: A school based cross-sectional study was conducted through self-administered questionnaires. The sample size was determined using single population proportion formula. Data was entered and cleaned using EPI info version 7 and exported and analyzed using Statistical Package for Social Sciences (SPSS) version 20. Logistic regression model was used to measure the association of outcome and independent variables. RESULT: 567 Adigrat high school students participated in the study. This study revealed that 17.6% of the study participants had practiced premarital sexual intercourse before the study period. The variables found to be associated with premarital sexual practice were, educational level, attending entertainment programs, sexual communication with friends and use of addictive substances. CONCLUSION AND RECOMMENDATION: There were a substantial proportion of high school students who practiced premarital sexual intercourse. Therefore, collaborative effort needs to address sexual and reproductive health issues of students related to premarital sexual practice.
TORÇÃO UTERINA EM VACA HOLANDESA: CORREÇÃO E EVOLUÇÃO DO CASO
Authors: Seibel Renata , Barcellos Leonardo José Gil , Moraes Rayssa Emiliavaca de
Published: August 2024

A torção uterina consiste em um movimento rotacional do útero sobre seu eixo longitudinal. Entre os fatores de risco, estão a idade e o número de partos, peso excessivo do feto, transporte dos animais e pastoreio em áreas de declive, além da contenção e derrubamento de vacas ao final da gestação. Os sinais clínicos variam conforme o grau da torção, contudo, podem ser observados taquicardia, dispneia, algia, abdome tenso, além de dificuldade em se locomover. O diagnóstico, portanto, baseia-se na palpação vaginal e/ou transretal. Dependendo do caso, a correção pode ser feita pelo método cirúrgico por meio da cesariana ou, então, por manobras obstétricas, como é o caso do rolamento. O objetivo deste relato é o de descrever o caso de uma vaca holandesa, com aproximadamente cinco anos de idade, que apresentou distocia devido a torção uterina completa. Após a correção da torção uterina, a paciente apresentou cetose, metrite e deslocamento de abomaso à esquerda, e várias condutas foram empregadas para a resolução desses problemas. Com a resolução do caso, a paciente permaneceu viva e, atualmente, segue sua vida produtiva.
Climate Change and Aspen 2014
Authors: Arnott James ,   Aspen Global Change Institute, Katzenberger John , Osenga Elise
Published: August 2024

In 2014, AGCI completed a second study intended to support the City of Aspen in preparing for the impacts of climate change through resiliency planning. More information about the City’s resiliency planning effort can be found on their website, www.ourfutureaspen.com.
EVALUATE THE RESULTS OF THE QI GONG NOURISHES HEALTH EXERCISE METHOD IN POST-COVID-19 TREATMENT
Authors: PGS Vân , Ngô Thuật , PGS Vân , TS ĐÔNG
Published: August 2024

Objective : Evaluate the treatment effectiveness of the Qi Gong nourishes health practice method and some related factors in post-COVID-19 treatment. Research method : Clinical intervention, before-after comparison of treatment on 121 patients with post-COVID-19 disorders according to modern medicine and belongs to the Lung and Spleen qi deficiency of traditional medicine, came for examination and treatment. treatment at the National Hospital of Acupuncture from March to October 2023. Patients can practice Qi Gong nourishes health Nguyen Van Huong exercise once a day, 30-45 minutes each time. Evaluation criteria include dyspnea (mmrc scale), fatigue (Borg-CR scale), quality of life score (EQ-5D-5L scale) on days D0, D15 and D30 after treatment. The collected data are processed using SPSS 20.0, the difference is statistically significant when p < 0.05. The study complied with 13 principles of biomedical ethics. Results: Excellent and good effectiveness 68.6%. Clinical symptoms of modern medicine and traditional medicine improved statistically significantly compared to the time before treatment (p<0.05), quality of life score EQ-5D-5L excellent reached 39.7 %; good reached 43%; 17.3% Average; The level of shortness of breath gradually improved, the effectiveness after treatment reached excellent 30.5%; good 57%; Average 12.4%; Fatigue level improved excellently, effectiveness after treatment reached 81.8% excellent; 16.5% good and 1.7% Average. Conclusion : Nguyen Van Huong's Qi Gong nourishes health practice method is excellently effective in improving post-COVID-19 disorders of the Lung and Spleen qi deficiency.
A Literature Review on the Impact of Legal Reforms on Administrative Efficiency in Local Governments
Authors: Pramono Wahyu , Hariadi Berian , Mulia Rizki Afri , Putri Rianda Prima , Meilina Susiyanti , Suryaningsih Suryaningsih
Published: August 2024

This research paper offers an extensive literature review concerning the effects of legal alterations on the operational efficiency of municipal administrations. Despite implementing numerous legislative modifications to improve administrative efficacy, many local governing bodies encounter obstacles such as bureaucratic procedures, corruption, and insufficient institutional capabilities. Successful instances in nations like South Korea and Singapore underscore the significance of digitalization within public administration and unwavering political dedication in overcoming these hindrances and bolstering transparency. Conversely, in regions such as India and various African countries, obstacles like institutional shortcomings and widespread corruption hinder the effectiveness of reform initiatives. Critical elements for the success of such reforms encompass institutional capacity, political backing, and the integration of information and communication technologies. Public involvement and the effective management of bureaucratic opposition are also paramount. This analysis furnishes valuable insights for policymakers and scholars aiming to devise and execute more effective legal reforms. Policy recommendations entail continual training for governmental officials, persistent political dedication, and customized strategies tailored to local reform implementation obstacles.
Graph-Enhanced Spatio-Temporal Interval Aware Network for Next POI Recommendation in Mobile Environment
Authors: Zhang Xu , Liu Deao , Yan Liang , Zhang Zhiqing , Li Yan
Published: August 2024

With the rapid spread of mobile device, technologies in mobile cloud increased quick and introduce huge volume of mobile data and computation. Human movement between POIs are recorded in mobile cloud, which indicate personalized behaviors. Most POI recommendation method in mobile cloud proposed to utilize recurrent neural networks and self-attention mechanism to discover users’ potential movement behaviors. In this paper, we propose a graph-enhanced spatio-temporal interval aware network (GESTIAN) to recommend the next POI. In GESTIAN, we propose a graph-based general pattern learning module to learn common behavior patterns based on a global trajectory flow graph to address the challenges caused by cold start. Furthermore, we propose a heterogeneous network with spatio-temporal interval aware with self-attention and gate recurrent unit to extract users’ long-term and short-term spatio-temporal dependencies, respectively. In addition, we leverage the scale between positive and negative samples by randomly sampling negative samples. We conduct extensive experiments based on two real-world check-in datasets. The experimental evaluations demonstrate that the proposed GESTIAN outperforms most challenging baselines by approximately 2%-10%, and achieves better performance over few-check-in history users.
Analysis of Online Business Development in The Modern Era According to Islamic View
Authors: Fardian Firmansyah
Published: August 2024

This scientific research was made using qualitative developmental research methods. This qualitative research method is defined as a research method based on the philosophy of postpositivism, where the researcher is used as the key instrument, the data processing technique is carried out in a combined way. Data analysis is deductive in nature, in this case the author of the article looks for assumptions about questions that have been asked by other people in the past. This is done in order to facilitate the process of doing this research. While the sampling technique used snowball sampling technique, with this method can obtain information through interviews. It is also a rule to obtain research information must interview 10 people. The object of this journal is in the form of writing about online business that continues to grow according to the Islamic view. Regarding the population itself, how is the process of developing online business in this modern era. Online business is now increasingly popular among young people and adults, because the income from the online business itself is very tempting. Where only a little capital can profit a lot. The existence of this journal is to explain how the views of Islam are related to online business that continues to develop in modern times. The results of this scientific study are based on the Islamic view of businesses that use online systems that must comply with Islamic law. The Prophet himself stated that buying and selling was lawful. Doing business online itself can have a very influential impact on society because it is easy, practical, and fast. If you want to do business online there is no usury, there is fraud, there is deception, then online is not in accordance with Islam. Any business model, especially online business that is carried out based on the Qur'an and the Hadith of the Prophet Muhammad SAW.
Konstitusionalitas Pengaturan Tindak Pidana Administrasi Dalam Undang-Undang
Authors: Ahmad Furqan Darajat  , Humam Balya
Published: August 2024

Penelitian ini bertujuan untuk menjawab rumusan masalah : Bagaimana pertimbangan Hukum dalam putusan Mahkamah Agung No. 16 K/AG/2010.?; Bagaimana Kesesuaian Putusan Mahkamah Agung dengan Hukum Islam ? Data penelitian ini diperoleh melalui studi pustaka dan studi dokumen. Selanjutnya data tersebut dianalisis dengan metode deskriptif analisis dengan menggunakan pola fikir deduktif yakni menjelaskan secara umum selanjutnya penulis menganalisis tentang dasar-dasar hukum dan aturan-aturan tentang pembagian harta waris dalam kawin beda agama. Majelis hakim Mahkamah Agung menggunakan pendapat seorang ulamaâ€™ Yusuf al-Qarad}awi sebagai dasar dalam memutus perkara ini, dalam pendapatnya Yusul al-Qarad{awi memperbolehkan seorang muslim mendapatkan harta waris dari non muslim, serta majelis hakim menimbang lamanya masa perkawinan antara pewaris dan tergugat selama 18 tahun. Hasil analisis menyebutkan bahwa majelis hakim mahkamah agung menggunakan pendapat Yusuf al-Qarad}awi yang memperbolehkannya seorang muslim mendapatkan waris dari non muslim, akan tetapi majlis hakim mahkamah agung sebaliknya, memberi waris kepada non muslim dan itu tidak sesuai dengan syariat Islam. Jadi, sangatlahtidaktepatjikamajelis hakim mahkamah agung menggunakan pendapat tersebut sebagai dasar pertimbangan dalam memutus perkara tersebut. Berdasarkan kesimpulan diatas diharapkan agar pemerintah memberikan aturan yang jelas tentang hukum kewarisan, agar di lain waktu tidak terjadi salah penafsiran dalam menetapkan hukum, dan diharapkan kepada para penegak hukum lebih cermat dan lebih berhati-hati dalam menetapkan hukum, supaya tidak terjadi pelanggaran hukum yang berlaku di Indonesia
Ushul Fiqh Dan Qawaid Al-Fiqhiyyah Sebagai Metode Istinbath Pengembangan Produk Lembaga Keuangan Syariah
Authors: Kamrullah
Published: August 2024

Ushul fiqh dan qawaid al-fiqhiyyah merupakan dua disiplin ilmu yang sangat urgen bagi para ahli hukumIslam dalam pengembangan produk perbankan syriâ€™ah, karena dengan kedua ilmu ini, seorang mujtahid atau ahli hukumIslam, dapat memperoleh kemudahan untuk mengetahui hukum-hukum kontemporer ekonomi yang tidak terdapat dalamnash sharÃ®h (dalil pasti) dalam Al-quran maupun al-hadis. Selain itu, ilmu Ushul al-Fiqh dan Qawaid al-fiqhiyyah juga dapat mempermudah untuk memahami dan menguasai permasalahan furÃ»â€™iyah atau fiqhiyyah yang terus berkembang dengan laju perkembangan zaman, situasi dan kondisi, dan itu semua tidak terhitung jumlahnya.  Ilmu ushul fiqh dan qawaid al-fiqhiyyah dalam bidang ekonomi bisa menjadi sebuah solusi dalam menjastifikasi dan memberikan ligitimasi terhadap seluruh gerak aktifitas ekonomi perbankan dalam berbagai bidang transaksi (muamalah), yang bilamana semua itu sudah  sesuai dengan prinsip syariâ€™ah yakni, tidak bertentangan nash danmaqhasid al-syariâ€™ah.
Tradisi Keagamaan Masyarakat Pesisir(Studi Kasus Masyarakat Nelayan Desa Ketapang Raya Kecamatan Keruak
Authors: Lenny Herlina
Published: August 2024

Tradisi dan perwujudan ajaran agama memiliki keterkaitan yang erat, karena itu tradisi tidak dapat dipisahkan begitu saja dari masyarakat atau lembaga dimana ia dipertahankan, sedangkan masyarakat juga memiliki hubungan timbal balik bahkan saling mempengaruhi dalam agama. Agama mempengaruhi jalannya masyarakat dan pertumbuhan masyarakat mempengaruhi pemikiran terhadap agama. Keberagamaan manusia, pada saat yang bersamaan selalu disertai dengan identitas budayanya masing-masing yang berbeda-beda. Beberapa sikap keagamaan yang tampak dalam diri seseorang dalam menjalankan tugasnya, diantaranya adalah kejujuran, keadilan, bermanfaat bagi orang lain, rendah hati, bekerja efisien, visi kedepan, disiplin tinggi, dan keseimbangan. Secara umum budaya dapat terbentuk secara prescriptive dan dapat juga secara terprogram sebagai bagian dari proses pembelajaran atau solusi terhadap suatu masalah. Pertama adalah pembentukan atau terbentukanya tradisi keagamaan melalui penuturan, peniruan, penganutan dan penataan suatu tradisi dari atas atau dari luar pelaku budaya yang bersangkutan. Kedua pembentukan budaya secara terprogram melalui proses pembelajaran. Pola ini bermula dari dalam diri pelaku budaya, dan suatu kebenaran, keyakinan, anggapan dasar atau dasar yang dipegang teguh sebagai pendirian, yang kemudiandiaktualisasikan menjadi kenyataan melalui sikap dan perilaku
КАЗАХСТАНСКАЯ СТОМАТОЛОГИЧЕСКАЯ АССОЦИАЦИЯ
Authors: Темирбаев М.А.
Published: August 2024

История возникновения Казахстанской стоматологической ассоциации начинается с 25 декабря 1991 года и тесно связана с приобретением суверенитета Республики Казахстан. КСА развивалась вместе с развитием нашей страны и создана путем добровольной ассоциации граждан, которая действует на основании Конституции, Гражданского кодекса, Закона “Об общественных Объединениях” и других нормативных правовых актов Республики Казахстан.
Hacia un análisis del retorno social de la contratación pública mediante la contabilidad social
Authors: Alea Arrate Beloke
Published: August 2024

El sector público ha recurrido tradicionalmente al sector privado con el objetivo de realizar proyectos de interés general, articulando dichas colaboraciones a través de distintos instrumentos jurídicos. En concreto, la colaboración público-privada de tipo contractual ha sido objeto de una notable evolución desde sus orígenes, positivizada en las distintas disposiciones de carácter normativo. En la actualidad, la contratación pública se concibe como una herramienta al servicio del sector público para el cumplimiento efectivo de sus fines.El presente artículo tiene como objetivo realizar un análisis sobre la viabilidad jurídica de utilizar la contabilidad social como herramienta para evaluar el retorno social generado por las empresas –el sector privado– en el desarrollo de los contratos del sector público. Esta herramienta, de igual manera, pretende visibilizar el valor generado por las empresas de economía social, en coherencia con el fomento que pretende la propia Ley de Contratos del Sector Público.
Cooperativa de trabajo asociado en fraude de ley
Authors: Arnau Cosín María José
Published: August 2024

En esta sentencia se analizan las consecuencias derivadas de un supuesto de una cooperativa de trabajo asociado de transportes en fraude de ley o falsa cooperativa, desde una perspectiva jurídico penal. El presidente de la cooperativa es acusado y así lo confirma la Sala de lo Penal del Tribunal Supremo, tras la inadmisión del recurso de casación planteado, de dos delitos: un delito contra las personas trabajadoras y otro delito de estafa agravada por ser el trabajo un bien de primera necesidad, así como por la gravedad de la conducta y por la cuantía defraudada. Al margen de la condena penal, es de gran interés, revisar el supuesto fraude cooperativo y laboral que se ha producido en el presente caso.
Fermented calabash fruit-derived choline (Crescentia cujete L.) against artificial-induced ischemic stroke in rat models: Analysis of N/LR, PWR, histopathology, GM-CSF, and VEGF
Authors: Prakoso Yos Adi , Hidayah Jasir Hakim , Widyarini Sitarina
Published: August 2024

Ischemic stroke is commonly caused by a thrombus and its standard treatment may have side effects. Hence, the alternative therapy against ischemic stroke requires elucidation. This study aimed to analyse the efficacy of fermented calabash fruit-derived choline (Crescentia cujete L.) (FC-C) against ischemic stroke. This study consisted of four groups: CO (sham-operated group); and the other groups (CU, FC, and PR) were artificially induced ischemic stroke, while CU (untreated); FC (2.94 mg/kg BW FC-C); and PR (496 mg/kg BW piracetam). The therapy was applied for 14 days. The neuro-deficit, blood, and brain samples were collected and the data was analysed. The results showed that the FC-C potentially affects the body weight and neuro-deficit score in rats with artificial-induced ischemic stroke compared to the other treatments. The score of neuro-deficit correlated to the percentage of infarct area in the FC group that indicated the smallest area than the others. Utilization of FC influenced the decrease of the level of N/ LR, promoted the histopathological repair, and increased expression and level of granulocyte-macrophage colonystimulating factors (GM-CSFs) and vascular endothelial growth factor (VEGF), but not regarding the platelet-towhite blood cell ratio (PWR). In conclusion, FC-C has beneficial effects for artificial ischemic stroke in rat models. The advanced study regarding the safety of FC-C must be elucidated to support the current findings.
Computational investigation into Parinari curatellifolia flavonoids as lead hepatoprotective therapeutics
Authors: Amobonye Ayodeji , Sabiu Saheed , Olaleye Mary Tolulope , Pillai Santhosh
Published: August 2024

Parinari curatellifolia (PC), an indigenous African plant has numerous nutritional, and medicinal benefits, including hepatoprotection. Following the established approach of using plant metabolites as prototype drugs, flavonoids from PC were investigated as potential hepatoprotective therapeutics using in silico approach. Initially, the flavonoids were identified by high performance liquid chromatography (HPLC), afterwards, their drug-likeness, biological activities, and toxicity were predicted using different algorithms and softwares. HPLC revealed 3-methylquercetin, chrysin, kaempferol, quercetin, pinocembrin, tricetin, apigenin, baicalein, genistein, isorhamnetin, and myricetin as prominent flavonoids in PC extract. Furthermore, all the compounds fulfilled Lipinski’s rule of five, were predicted to be non-toxic, and were also shown by prediction of activity spectra for substances to demonstrate probable hepatoprotection mechanisms. Molecular docking of the Parinari flavonoids and Cytochrome P450 1A1 showed binding energy scores ranging from −8.7 to −10.2 kcal/mol, while molecular dynamic simulation confirmed the stability of the complexes formed with ΔGbind ranging from −35.85 to –32.00. Hence, this study establishes the hepatoprotective effect of the natural PC compounds and proposes the activation of Cytochrome P450 1A1 as a major mechanism of action. In addition, a successful effort has been made to validate previously reported flavonoid activities of PCs using a comprehensive computational approach.
Belgijska klinika kryminologiczna a rozwój nauk społecznych i prawo karne
Authors: Stępniak Piotr Andrzej
Published: August 2024

Artykuł omawia genezę, rozwój oraz perspektywy kryminologii klinicznej. Autor przedstawia nowy jej paradygmat, związany ze Szkołą Kryminologii Katolickiego Uniwersytetu w Louvain-la-Neuve. Jest on formułowany w związku z rozwojem nauk społecznych, ściślej z teorią interakcjonizmu symbolicznego oraz kontroli społecznej. W tekście zawarto opis narodzin oraz rozwoju kryminologii klinicznej ze szczególnym uwzględnieniem prac Étienne’a De Greeffa, Christiana Debuysta i in. W takim kontekście autor zastanawia się nad koniecznością bardziej dialektycznego sposobu myślenia w kryminologii, a także wieloaspektowego, interdyscyplinarnego rozumienia zjawisk kryminalnych. W ramach tej dyskusji analizuje istotę podejścia klinicznego, próby jego połączenia z podejściem interdyscyplinarnym, a także zintegrowania podejścia psychologicznego z wiedzą socjologiczną, psychoanalizą i psychopatologią. Omawia teoretyczną podstawę takiej syntezy, tj. koncepcję przestępcy jako aktora społecznego. Autor ocenia miejsce i wkład kryminologii klinicznej do kryminologii światowej, a także wpływ na politykę karną oraz rozwój myśli kryminologicznej w Polsce. Tekst kończą uwagi o tzw. trzeciej drodze rozwoju współczesnej kryminologii, która byłaby efektem syntezy różnych podejść i koncepcji kryminologicznych.   The article discusses the genesis, development, and prospects of clinical criminology. The author presents the new paradigm related to the School of Criminology of the Catholic University of Louvain-la-Neuve. This problem is formulated in connection with the development of social sciences, more precisely with the theories of symbolic interactionism and social control. The text describes the birth and development of clinical criminology, with a particular emphasis on the works of Etienne de Greeff, Christian Debuyst and others. In this context, the author considers the need for a more dialectical way of thinking in criminology, as well as a multi-faceted, interdisciplinary understanding of criminal phenomena. As part of such a discussion, he analyzes the essence of the clinical approach, combines it with an interdisciplinary approach, and integrates the psychological approach into sociology, psychoanalysis, and psychopathology. He discusses the theoretical basis of such a synthesis: the concept of an offender as a social actor. The author evaluates the place and contribution of clinical criminology to world criminology, as well the impact on criminal policy and the development of criminological thought in Poland. The text ends with comments about the so-called third way of development of modern criminology, which would be the result of synthesizing various criminological approaches and concepts.
A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia
Authors: Kwon Hyo Jun , Santhosh Devi , Huang Zhen
Published: August 2024

Amyloid β (Aβ) forms aggregates in the Alzheimer’s disease brain and is well known for its pathological roles. Recent studies show that it also regulates neuronal physiology in the healthy brain. Whether Aβ also regulates glial physiology in the normal brain, however, has remained unclear. In this article, we describe the discovery of a novel signaling pathway activated by the monomeric form of Aβ that plays essential roles in the regulation of microglial activity and the assembly of neocortex during development. We find that activation of this pathway depends on the function of amyloid precursor (APP) and heterotrimeric G proteins in microglia and inhibits microglial immune activation at transcriptional and post-transcriptional levels. Genetic disruption of this pathway during neocortical development results in microglial dysregulation and excessive matrix proteinase activation, leading to basement membrane degradation, neuronal ectopia, and laminar disruption. These results uncover a previously unknown function of Aβ as a negative regulator of brain microglia and substantially elucidate the molecular mechanisms underlying this regulation. Considering the prominence of Aβ and neuroinflammation in the pathology of Alzheimer’s disease, they also highlight a potentially overlooked role of Aβ monomer depletion in the development of the disease.
Augmented Reality-based Learning Media for Very High Frequency Omni-directional Range (VOR) Navigation Training
Authors: Djunaedi  , Sahrul  , Yahya Muhammad
Published: August 2024

This research aims to develop Augmented reality (AR) based learning media for the Very high frequency omni directional range (VOR) course as a navigation aid at Aviation Polytechnic. The use of AR technology is expected to improve the understanding and practical skills of cadets in understanding the concepts and operations of VOR. The research method used is Research and Development (R&D) with the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation). At the analysis stage, learning media needs were identified through surveys and interviews with lecturers and cadets. The design stage involves designing storyboards and AR usage scenarios for VOR material. Development is done by creating AR applications that can be accessed through mobile devices. Implementation is done by integrating AR learning media into the teaching process in class and laboratory. Evaluation is done to measure the effectiveness of AR learning media through trials and assessments from cadets and lecturers. The results showed that AR-based learning media increased cadets' learning engagement and motivation, and facilitated the understanding of complex VOR concepts. The effectiveness evaluation showed a significant increase in learning outcomes in cadets using AR media compared to conventional learning methods. Based on these findings, AR learning media is recommended to be implemented in the future.
Seasonal Abundance of Thrips in Rabi Onion under Southern Telangana Climatic Conditions
Authors: Supraja K. V. L. , Kavitha K. , Kumari D. Anitha , Reddy M. Venkateswara
Published: August 2024

Aims: Onion (Allium cepa L.) belongs to family Amaryllidaceae (Alliaceae) is one of the most important commercial vegetable and condiment crop grown in India. Given the economic significance of the crop, the current study was conducted to determine the population fluctuations in thrips population in relation to weather parameters.
Study Design: RBD (One factor Analysis).
Place and Duration of Study: The experiment was carried out at Vegetable Research Station, ARI, SKLTSHU, Rajendranagar, Hyderabad during Rabi 2023-24.
Methodology: 300 m2 plot was demarcated for seasonal incidence studies and the area was divided into five quadrants i.e., four on the corners and fifth was taken in the middle of the plot. The observations were recorded on the number of thrips per plant by selecting 10 plants randomly from each quadrant at weekly intervals i.e., SMW wise from transplanting till harvest during morning hours between 7.00 AM to 9.00 AM through visual counting by tapping method using 10X magnifying lens (Apexel 2 in 1 12x/24x Super Macro Mobile Lens).
Results: The initial infestation of thrips (5.64 thrips/plant) was observed during the seedling stage i.e., fifteen days after transplantation (51st SMW) and the peak population of the (42.34 thrips/plant) was recorded during 8th SMW at the physiological maturity stage. It was observed that there was a significantly positive correlation with maximum temperature (r=0.831**) and minimum temperature (r=0.602*), was found to be non-significant and negatively correlated with morning relative humidity (r=-0.496), significant and negatively correlated with evening relative humidity (r=-0.837**).
Conclusion: Studies on the seasonal abundance of thrips in Rabi onion are essential for understanding their population fluctuations and aid in developing forecasting models and devising appropriate management strategies based on the crop’s growth stage.
Interplate seismicity at the CRISP drilling site: The 2002 Mw 6.4 Osa Earthquake at the southeastern end of the Middle America Trench
Authors: Arroyo Ivonne G. , Grevemeyer Ingo , Ranero Cesar R. , von Huene Roland
Published: July 2014

We investigate potential relations between variations in seafloor relief and age of the incoming plate and interplate seismicity. Westward from Osa Peninsula in Costa Rica, a major change in the character of the incoming Cocos Plate is displayed by abrupt lateral variations in seafloor depth and thermal structure. Here a Mw 6.4 thrust earthquake was followed by three aftershock clusters in June 2002. Initial relocations indicate that the main shock occurred fairly trenchward of most large earthquakes along the Middle America Trench off central Costa Rica. The earthquake sequence occurred while a temporary network of OBH and land stations ∼80 km to the northwest were deployed. By adding readings from permanent local stations, we obtain uncommon P wave coverage of a large subduction zone earthquake. We relocate this catalog using a nonlinear probabilistic approach within both, a 1‐D and a 3‐D P wave velocity models. The main shock occurred ∼25 km from the trench and probably along the plate interface at 5–10 km depth. We analyze teleseismic data to further constrain the rupture process of the main shock. The best depth estimates indicate that most of the seismic energy was radiated at shallow depth below the continental slope, supporting the nucleation of the Osa earthquake at ∼6 km depth. The location and depth coincide with the plate boundary imaged in prestack depth‐migrated reflection lines shot near the nucleation area. Aftershocks propagated downdip to the area of a 1999 Mw 6.9 sequence and partially overlapped it. The results indicate that underthrusting of the young and buoyant Cocos Ridge has created conditions for interplate seismogenesis shallower and closer to the trench axis than elsewhere along the central Costa Rica margin.
The 10,240‐member ensemble Kalman filtering with an intermediate AGCM
Authors: Miyoshi Takemasa , Kondo Keiichi , Imamura Toshiyuki
Published: July 2014

The local ensemble transform Kalman filter (LETKF) with an intermediate atmospheric general circulation model (AGCM) is implemented with the Japanese 10 petaflops (floating point operations per second) “K computer” for large‐ensemble simulations of 10,240 members, 2 orders of magnitude greater than the typical ensemble size of about 100. The computational challenge includes the eigenvalue decomposition of 10,240 × 10,240 dense covariance matrices at each grid point. Using the efficient eigenvalue solver for the K computer, the LETKF computations are accelerated by a factor of 8, allowing a 3 week experiment of 10,240‐member LETKF with an intermediate AGCM for the first time. The flow‐dependent 10,240‐member ensemble revealed meaningful long‐range error correlations at continental scales. The surface pressure error correlation shows teleconnection patterns like the Pacific North American pattern. Specific humidity error correlation shows continental scale wave trains. Investigations with different ensemble sizes suggest that at least several hundred members be necessary to capture these continental scale error correlations.
Light attenuation characteristics of glacially‐fed lakes
Authors: Rose Kevin C. , Hamilton David P. , Williamson Craig E. , McBride Chris G. , Fischer Janet M. , Olson Mark H. , Saros Jasmine E. , Allan Mathew G. , Cabrol Nathalie
Published: July 2014

Transparency is a fundamental characteristic of aquatic ecosystems and is highly responsive to changes in climate and land use. The transparency of glacially‐fed lakes may be a particularly sensitive sentinel characteristic of these changes. However, little is known about the relative contributions of glacial flour versus other factors affecting light attenuation in these lakes. We sampled 18 glacially‐fed lakes in Chile, New Zealand, and the U.S. and Canadian Rocky Mountains to characterize how dissolved absorption, algal biomass (approximated by chlorophyll a), water, and glacial flour contributed to attenuation of ultraviolet radiation (UVR) and photosynthetically active radiation (PAR, 400–700 nm). Variation in attenuation across lakes was related to turbidity, which we used as a proxy for the concentration of glacial flour. Turbidity‐specific diffuse attenuation coefficients increased with decreasing wavelength and distance from glaciers. Regional differences in turbidity‐specific diffuse attenuation coefficients were observed in short UVR wavelengths (305 and 320 nm) but not at longer UVR wavelengths (380 nm) or PAR. Dissolved absorption coefficients, which are closely correlated with diffuse attenuation coefficients in most non‐glacially‐fed lakes, represented only about one quarter of diffuse attenuation coefficients in study lakes here, whereas glacial flour contributed about two thirds across UVR and PAR. Understanding the optical characteristics of substances that regulate light attenuation in glacially‐fed lakes will help elucidate the signals that these systems provide of broader environmental changes and forecast the effects of climate change on these aquatic ecosystems.
Metal Sandwiches and Metal‐Matrix‐Composites Based on 3D Woven Wire Structures for Hybrid Lightweight Construction
Authors: Sennewald Cornelia , Kaina Steffen , Weck Daniel , Gruhl Andreas , Thieme Mike , Hoffmann Gerald , Stephani Günter , Böhm Robert , Cherif Chokri , Andersen Olaf , Kieback Bernd , Hufenbach Werner A.
Published: July 2014

Within this paper the development of 3D woven wire structures in cellular design for multifunctional multi component‐composite semi‐finished products for economically efficient and resource‐conserving processing into hybrid lightweight constructions is described. These structures can be produced in a modified weaving process and are supplied for subsequent processing such as joining and heat treatment. The developed 3D woven wire structures are predestined for the use in lightweight structures due to their high geometric variability, adjustable mechanical properties, and temperature‐resistance at a low specific weight. The structures are used as core material in sandwich construction or reinforcing material in metal matrix composites. By combining such wire structures with carbon fibers, a new class of material especially suitable for infiltration with metal matrix can be realized with outstanding high mechanical properties such as good impact and crash resistance as well as a high flexibility regarding the choice of materials and optimized structural design. Experimental investigations of mechanical properties and the failure behavior of textile based metal sandwiches and metal‐matrix‐composites with wire reinforcement have been carried out. For this purpose, extensive static and dynamic tests have been performed. The mechanical properties are compared to commercial lightweight materials of the same class as a benchmark.
Manufacture and Testing of Thermoelectric Modules Consisting of BxC and TiOx Elements
Authors: Feng Bing , Martin Hans‐Peter , Börner Floriana‐Dana , Lippmann Wolfgang , Schreier Max , Vogel Karin , Lenk Andreas , Veremchuk Igor , Dannowski Marcel , Richter Christin , Pfeiffer Peter , Zikoridse Gennadi , Lichte Hannes , Grin Juri , Hurtado Antonio , Michaelis Alexander
Published: July 2014

The synthesis and production of thermoelectrical active ceramic materials, the concepts of the module design by simulation, the assembly of modules by laser joining, and the investigations concerning the operation modes are described in this paper. Investigations of the material structure, the phase composition, and the thermoelectrical properties illustrate the material development. The newly developed technological route is described. The simulated results of thermoelectric modules for operational cases are compared with gained experimental data.
High Enhanced Efficiency and Mechanism of Ultra‐Long SiC Nanowires in Composites
Authors: Wei Jian , Li Kezhi , Yuan Hudie , Hao Rui
Published: July 2014

Ultra‐long SiC nanowires with large aspect ratios of 2 × 104–5 were incorporated successfully into epoxy resin to form SiC nanowires/epoxy composite via a preliminary homogenously dispersive process in ethanol. 9.7 and 13.3% bending strength increases were achieved for the composites with the addition of very small quantity (0.1 and 0.125 wt%) of ultra‐long SiC nanowires. The prepared ultra‐long SiC nanowires have the highest enhanced efficiency than other shorter ones in epoxy resin composites. Microstructure analysis implies that the nanowire disperse homogenously in the composite and have well combination with matrix. The ultra‐long nanowires can exert their extraordinary high modulus and tensile strength of SiC nanowires in this condition. The obtained high enhanced efficiency is the mutual effect of high modulus and strength, large aspect ratio, fine distributed state, moderate interface bondings, and formed a three‐dimensional network of the ultra‐long SiC nanowires.
Radiographic evaluation of stillbirth: What does it contribute?
Authors: Swenson Erica , Schema Lynn , McPherson Elizabeth
Published: July 2014

Despite advances in perinatal care, stillbirth is relatively common (1/160 births) and frequently remains unexplained. Most recent protocols for etiologic evaluation of stillbirth either omit radiography or reserve it for infants with obvious skeletal disproportion. Over the past 30 years, the Wisconsin Stillbirth Service Program has collected radiographic images from 2,032 stillbirths and second trimester losses, of which about 25% (517) showed abnormalities. Review of these images by a medical geneticist showed that radiographs yielded a diagnosis in 45% of the infants with abnormalities (11.5% of all radiographs obtained) and were critical, yielding a diagnosis that would otherwise have been missed or incomplete in 1.5% of the total infants. The probability of a diagnosis was not significantly different between miscarriages <20 weeks and stillbirths. Diagnoses were mainly fetal, most commonly sporadic birth defects, idiopathic hydrops, chromosome abnormalities, and skeletal dysplasias, but chorioamnionitis with fetal sepsis, complications of twinning, and cord accidents were also diagnosed radiographically. Radiographs may help direct the use of newer technologies such as chromosomal microarray or gene sequencing. Limiting radiographs to infants with obvious skeletal disproportion would have resulted in many of these diagnoses, including 4/24 skeletal dysplasias, being overlooked. We recommend at least an anterior/posterior babygram film as part of the permanent record of all second trimester losses and stillbirths. © 2014 Wiley Periodicals, Inc.
Acroscyphodysplasia as a phenotypic variation of pseudohypoparathyroidism and acrodysostosis type 2
Authors: Mitsui Toshikatsu , Kim Ok‐Hwa , Hall Christine M. , Offiah Amaka , Johnson Diana , Jin Dong‐Kyu , Toh Teck‐Hock , Soneda Shun , Keino Dai , Matsubayashi Shohei , Ishii Tomohiro , Nishimura Gen , Hasegawa Tomonobu
Published: July 2014

Acroscyphodysplasia (OMIM250215) is a distinctive form of metaphyseal dysplasia characterized by the distal femoral and proximal tibial epiphyses embedded in cup‐shaped, large metaphyses known as metaphyseal scypho (“scypho” = cup) deformity. It is also associated with severe growth retardation and brachydactyly. The underlying molecular mechanism of acroscyphodysplasia has not yet been elucidated, although scypho‐deformity of the knee has been reported in three patients with acrodysostosis due to a mutation in the PDE4D gene. We report on the clinical, radiological, and molecular findings of five female patients with acroscyphodysplasia; two were diagnosed as pseudohypoparathyroidism (PHP) or Albright hereditary osteodystropy, and the other three as acrodysostosis. They all had radiological findings consistent with severe metaphyseal scypho‐deformity and brachydactyly. Heterozygous mutations were identified in the PHP patients consisting of one novel (p.Q19X) and one recurrent (p.R231C) mutation of the GNAS gene, as well as, in the acrodysostosis patients consisting of two novel mutations (p.T224I and p.I333T) of the PDE4D gene. We conclude that metaphyseal acroscyphodysplasia is a phenotypic variation of PHP or acrodysostosis caused by either a GNAS or PDE4D mutation, respectively. © 2014 Wiley Periodicals, Inc.
Protective properties of PPy‐Au nanocomposite coatings prepared by sonoelectrochemisty and optimized by the Taguchi method
Authors: Ashassi‐Sorkhabi Habib , Bagheri Robabeh , Rezaei‐Moghadam Babak
Published: July 2014

The polypyrrole (PPy) and polypyrrole‐Au (PPy‐Au) nanocomposite films have been sonoelectrochemically synthesized on St‐12 steel electrodes using the galvanostatic technique. Experimental design according to the Taguchi method has been applied to optimize the factors on the synthesis of PPy‐Au nanocomposite coating. Three factors were used to design an orthogonal array L9: Synthesis time (t), Current density (I), and Concentration of HAuCl4 (C). The synthesized Au nanoparticles during polymerization were characterized by Ultraviolet–visible (UV‐visible) spectroscopy. Characterization of the surfaces was done by scanning electron microscope (SEM), energy dispersive X‐ray spectrum (EDX), and atomic force microscope (AFM). The scanning electron microscopy (SEM) image of PPy shows a smooth surface while PPy‐Au nanocomposite film has a compact morphology. Moreover, energy dispersive X‐ray spectrum (EDX) is evidence for the incorporation of Au nanoparticles. The corrosion protection of coatings was investigated by open circuit potential (OCP) time trends, potentiodynamic polarization technique, and electrochemical impedance spectroscopy (EIS) in a NaCl 3.5% solution. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41087.
Primary Cell Cultures for Understanding Rat Epididymal Inflammation
Authors: Chapin Robert E. , Winton Timothy R. , Nowland William S. , Kumpf Steven W. , Davenport Scott , Karanian David , Streck Randal D. , Coskran Timothy M. , Barbacci‐Tobin Elsa G. , Houle Christopher , Campion Sarah N.
Published: July 2014

Treatment‐induced epididymal inflammation and granuloma formation is only an occasional problem in preclinical drug development, but it can effectively terminate the development of that candidate molecule. Screening for backup molecules without that toxicity must be performed in animals (generally rats) that requires at least 2 to 3 weeks of in vivo exposure, a great deal of specially synthesized candidate compound, and histologic examination of the target tissues. We instead hypothesized that these treatments induced proinflammatory gene expression, and so used mixed‐cell cultures from the rat epididymal tubule to monitor the induction of proinflammatory cytokines. Cells were exposed for 24 hr and then cytotoxicity was evaluated with the MTS assay and mRNA levels of Interleukin‐6 (IL‐6) and growth‐related oncogene (GRO) were measured. We found that compounds that were more toxic in vivo stimulated a greater induction of IL‐6 and GRO mRNA levels in vitro. By relating effective concentrations in vitro with the predicted Ceff, we could rank compounds by their propensity to induce inflammation in rats in vivo. This method allowed the identification of several compounds with very low inflammatory induction in vitro. When tested in rats, the compounds produced small degrees of inflammation at an acceptable margin (approximately 20×), and have progressed into further development
Cardiovascular event‐free survival after adjuvant radiation therapy in breast cancer patients stratified by cardiovascular risk
Authors: Onwudiwe Nneka C. , Kwok Young , Onukwugha Eberechukwu , Sorkin John D. , Zuckerman Ilene H. , Shaya Fadia T. , Daniel Mullins C.
Published: July 2014

The objective of this study was to estimate the risk of a cardiovascular event or death associated with modern radiation in a population of elderly female breast cancer patients with varying baseline cardiovascular risk. The data used for this analysis are from the linked Surveillance, Epidemiology, and End‐Results (SEER)‐Medicare database. The retrospective cohort study included women aged 66 years and older with stage 0–III breast cancer diagnosed between 2000 and 2005. Women were grouped as low, intermediate, or high cardiovascular risk based on the presence of certain clinical diagnoses. The risk for the combined outcome of a hospitalization for a cardiovascular event or death within 6 months and 24 months of diagnosis was estimated using a multivariable Cox model. The median follow‐up time was 24 months. Among the 91,612 women with American Joint Committee on Cancer (AJCC) stage 0–III breast cancer: 39,555 (43.2%) were treated with radiation therapy and 52,057 (56.8%) were not. The receipt of radiation therapy in the first 6 months was associated with a statistically significant increased risk for the combined outcome in women categorized as high risk (HR = 1.510; 95% CI, 1.396–1.634) or intermediate risk (HR = 1.415; 95% CI, 1.188–1.686) but not low risk (HR = 1.027; 95% CI, 0.798–1.321). Women with a prior medical history of cardiovascular disease treated with radiation therapy are at increased risk for an event and should be monitored for at least 6 months following treatment with radiation therapy.