bluuebunny/crossref_metadata_2025 huggingface dataset:
ABDOMINAL WALL RECONTRUCTION UTILIZING POSTERIOR COMPONENT SEPARATION TRANSVERSUS ABDOMINIS MUSSCLE RELEASE IN CASE OF HUGE INCISIONAL HERNIA
Authors: Laver O. P. , Patskan B. M.
Published: February 2025

Resume. Introduction. Postoperative ventral hernia is a fairly common postoperative complication that occurs in patients who have undergone laparotomy. Depending on various factors, such as age, obesity, contamination of the surgical field, and the number of previous surgical interventions, the probability of this complication varies from 5 % to 31 %.
A large ventral hernia is a challenge for the surgeon when reconstructing the abdominal wall, due to difficulties in closing the defect. Each case requires an individual approach for choosing a surgical technique. In the surgical treatment of giant ventral hernias, a mesh implant should always be used, and its retromuscular placement has a number of advantages when combined with the component separation technique.
Objective. To present a clinical case of reconstruction of the anterior abdominal wall using the posterior component separation technique in the TAR (Transversus abdominis muscle release) technique.
Materials and methods. The basis of this study was the anamnesis data, objective data, visualization data of the state of the abdominal wall according to the performed preoperative computer tomography of the abdominal organs, intraoperative photofixation of the surgical intervention and postoperative computer tomography in the second year after the surgical intervention.
Results. Analyzing the data of the objective examination, comparing the data of the preoperative and postoperative computer tomography of the abdominal cavity and abdominal wall, there are clear signs of successful reconstruction of the abdominal wall, the return of the muscles to their previous anatomical position, and complete elimination of the preoperative hernia defect.
Conclusion. According to the results of this clinical case:

Reconstruction of the abdominal wall by the method of posterior component separation in case of large ventral hernias allows to achieve full anatomical restoration of the muscles of the abdominal wall to their previous position, to eliminate large hernia defects and to use large mesh implants in the retromuscular position, avoiding their direct contact with the organs of the abdominal cavity.
The results of the computed tomography performed for the second postoperative year and their comparison with the preoperative study confirms the reliability and stability of the obtained result.
COMPARATIVE EVALUATION OF METHODS OF R EVASCULARIZATION OF ARTERIAL BLOOD FLOW I N PATIENTS WITH MULTI-LEVEL OCCLUSIVE-STENOTIC LESIONS OF MAIN ARTERIES IN OBLITERATING ATHEROSCLEROSIS OF THE LOWER EXTREMITIES
Authors: Shaprynskyi V. V.
Published: February 2025

Abstract. In Ukraine, from 3 to 10% of the population suffers from occlusive diseases of the arteries of the lower extremities. It is important, that the cause of lower limb ischemia in 45-50% of patients is an atherosclerotic impression.
The aim: to study the results of the treatment of multi-level occlusive-stenotic lesions of the main arteries of the lower extremities by choosing the optimal method of surgical revascularization in obliterating atherosclerosis.
Materials and methods: the research is based on the results of examination and treatment of 267 patients with critical ischemia of the lower extremity III, IV degrees according to Fontaine.
The results. In the case of a combination of occlusion of the superficial femoral artery with stenotic-occlusive lesion of the arteries of the popliteal segment against the background of obliterating atherosclerosis, the use of simultaneous revascularization of the two layers of the lesion allows to expand the indications for revascularization of the arteries in this category of patients and improve the results of treatment.
Conclusions: postoperative thrombosis of the reconstruction area in patients, who underwent complex restoration of the patency of the iliac-popliteal arterial segment in various combinations in order to correct the phenomena of critical ischemia occur in 10.5%, and in patients, who underwent restoration of the patency of the iliac-popliteal arterial segment without intervention on arteries of the distal channel – in 27.8%.
SARS-COV-2 VIRAL INFECTION AND THE POST-COVID-19 SYNDROME DEVELOPMENT DISRUPTS IMMUNO-RESISTANCE AND PROMOTES ONCOGENESIS
Authors: Klimova O. M. , Boyko V. V. , Lavinska О. V. , Agarkova A. M. , Hashina V. О. , Kritsak V. V.
Published: February 2025

Summary. A viral infection of COVID-19 with an acute and asymptomatic course can cause a chronic violation of immune resistance, damage to many organs and tissues, including the lungs. Induction of malignancy after COVID-19 may occur due to the mutagenic effect of this virus, which leads to a high risk of mortality. It is important to determine the factors of the post-COVID-19 syndrome (PCS) formation and predictors of the oncogenesis development.
The aim. To investigate the integral cytotoxicity of blood serum by screening biophysical characteristics and to detect violations of phagocytosis and receptor expression of CD16+ killer NK cells and CD8+ T lymphocytes and to determine the control points of immune resistance disorders for their personalized correction in different cohorts of patients with PCS and complicated lung cancer.
Materials and methods. Patients (n = 18) with a complicated course of lung cancer aged from 53 to 71 years were examined. We studied the content of DAMP fractions (spectrophotometry); oxygen-independent and oxygen-independent phagocytosis of neutrophils, expression of differentiation clusters on lymphocytes (light microscopy).
Results. In patients with malignant lesions of the lungs, screening methods revealed a decrease in serum electrical conductivity, which is reversible to its resistance against the background of a significant increase in the content of the DAMP oligonucleotide fraction (260 nm); the absorbing function of a large number of antigens increased, but the digestive function of neutrophils was insufficient in oxygen-independent phagocytosis; there was a low metabolic reserve of the NADPH-oxidase system in oxygen-dependent phagocytosis; changes in the ratio of cytotoxic T lymphocyte subpopulations. An increase in the CD16+ NK cells content of innate immunity and an increase in the expression of CD8+ killer/suppressor T lymphocyte receptors of the adaptive link of immunity was observed in response to the competitive effect of suppressor receptors.
Conclusions. It is appropriate to determine the control points of changes in innate and adaptive immunity for effective personalized treatment of oncological lung pathology against the background of immune resistance disorders formed during the PCS development. Along with surgical treatment, it is advisable to use substances of biotechnological origin of the new generation, activators of transcription factors of co-stimulatory molecules and monoclonal antibodies to co-suppressor receptors of CD16+ killer NK cells and CD8+ cytotoxic T lymphocytes.
INFORMATIVENESS OF SURROGATE AND SPECIFIC INDICES FOR THE DIAGNOSIS OF INSULIN RESISTANCE IN WOMEN OF EARLY REPRODUCTIVE AGE
Authors: Melnyk A. A.
Published: February 2025

Abstract. Insulin resistance (IR) is a disorder characterised by a decrease in the biological response to insulin. Prolonged hyperinsulinaemia has a devastating impact on women’s health and is a trigger for the development of matabolic, cardiovascular and reproductive diseases, which can be irreversible.
Stress, rapid weight loss and weight gain, obesity, abuse of fast carbohydrates, lack of physical activity contribute to the development of IR and require a quick response and timely prevention to maintain a woman’s health.
In the practice of a doctor, the determination of HOMA and Matsuda indices, insulin levels before and after a 75 g glucose load are widely used to diagnose IR.
Objective To study the factors influencing insulin secretion and to investigate the effectiveness of HOMA and Matsuda indices.
Materials and Methods. This study included 82 women of early reproductive age. They were divided into a study group and a control group. To facilitate data collection, a questionnaire was created, and anthropometric parameters such as height, weight, waist circumference (WC), and body mass index (BMI) were measured. Laboratory diagnostics were performed: luteinising hormone (LH), follicle-stimulating hormone (FSH), sex-binding globulin (BPG), thyroid-stimulating hormone (TSH), prolactin, dehydroepiandrosterone sulfate (DHEA-s), total testosterone, free testosterone index, HOMA-IR (Homeostasis Model Assessment of Insulin Resistance), glucose tolerance test (GTT) plus insulin determination, Matsuda index.
Results. A weak direct relationship was found between HOMA and OT (r=0.353576), BMI (r=0.36090423), TSH (r=0.212637559), and total testosterone (r=0.241491459). A weak direct relationship is observed between the Matsuda index and the duration of bleeding during the menstrual cycle (r=0.263762). There is an inverse weak relationship between total testosterone (r=-0.351298232) and Matsuda index. Insulin levels formed relationships with WC (r=0.321900051), BMI (r=0.333470666), TSH (r=0.249578215), and total testosterone (r=0.278921593). Insulin levels after a 75 g glucose load had a direct correlation with FSH levels (r=0.291379519).
Conclusions. The relationships between fasting insulin levels and those after a 75 g glucose load with the studied parameters were established: WC, BMI, TSH, total testosterone, FSH. Between the HOMA and Matsuda indices, there is a direct correlation with the studied indicators of WC, BMI, TSH, total testosterone, duration of bleeding during menstruation.
OBJECTIFICATION OF THE ASSESSMENT OF INVOLUTIONAL CHANGES IN THE FACE AND NECK
Authors: Bondarev R. V. , Logvinov Ye. O.
Published: February 2025

Abstract. Objective. To evaluate the clinical efficacy of the Merz scale for assessing structural changes in the upper, middle, and lower thirds of the face and neck in order to objectify involutional changes and develop a profile of domestic female patients seeking plastic surgery consultations.
Materials and Methods. The study involved the examination of 210 female patients with involutional changes in the face and neck. The Merz scale was used to objectify structural changes in the upper third of the face. The Merz scale was applied to assess changes in the upper, middle, and lower thirds of the face, as well as the neck.
Results. Among the domestic patients who sought aesthetic surgery consultations, the upper third of the face was the least problematic area. The total aesthetic score for the middle third of the face, according to the Merz scale, was (9.75±3.74), and the total aesthetic score for the lower third of the face and neck was (23.31±7.98).
Conclusions. The total aesthetic score for the face and neck in domestic patients seeking aesthetic surgery for the correction of problematic areas was (48.53±15.81) (range 12-79, median 49, Q1 39, Q3 62, IQR 23, CA -0.18). The use of the Merz scale to objectify the results of surgical correction of involutional changes in the face and neck appears promising for future research.
ALGORITHM FOR DIAGNOSING THE MIGRATION OF FOREIGN BODIES OF GUNSHOT ORIGIN
Authors: Khoroshun E. M. , Makarov V. V. , Negoduyko V. V. , Shchapov P. F. , Zamyatin P. M. , Verevkin I. V. , Suprun R. M.
Published: February 2025

Resume. The aim is to propose an algorithm for diagnosing the migration of foreign bodies of gunshot origin.
Materials and methods. We have analysed 90 cases of gunshot blind wounds of various localisations for a certain period, where there was a foreign body migration by different ways. All the wounded were male, the average age was (43.2±4.1) years. The number of migrated foreign bodies was 104. Multislice spiral computed tomography of the head, chest and abdominal organs, pelvis with and without contrast, radiographic examinations of the head, chest and abdominal organs, ultrasound examination of the heart, blood vessels, joints, abdominal organs, soft tissues, video esophagogastroduodenoscopy, video colonoscopy, video bronchoscopy were performed. Statistica 10 software (StatSoft, Inc., USA) was used for statistical analysis. Statistical processing of the study results was performed using non-parametric statistical methods. Mathematical data processing was performed according to generally accepted methods with the calculation of arithmetic averages.
Results. The algorithm for diagnosing the migration of foreign bodies of gunshot origin includes the following steps: examination of the wound site, primary radiography or multislice computed tomography (primary studies); if hollow organs are suspected to be damaged, endoscopic examinations are performed; if major vessels are suspected to be damaged, multislice computed tomography with angiographic contrast (final studies) and control studies: ultrasound, radiography and multislice computed tomography as indicated. Statistical analysis of the multi-stage sequential-parallel model showed an increase in the weighting coefficients from the initial diagnosis to the control diagnosis and indicates an increase in the effectiveness of the final and control diagnosis compared to the initial diagnosis.
Conclusions. The increase in the weighting coefficients from the primary to the control examination indicates an increase in the effectiveness of the final and control diagnostics compared to the primary diagnostics. The application of the algorithm for the diagnosis of foreign bodies of gunshot origin allows to determine the treatment tactics and the scope of surgical intervention.
SURGICAL CARE FOR INJURIES TO THE PELVIC AND INTRAPARATIC ORGANS
Authors: Zamyatin P. M. , Gasanov N. G. , Cheverda V. M. , Istomin А. G. , Miroshnichenko Yu. V.
Published: February 2025

Summary. The goal. In 2/3 of victims with closed abdominal trau­ma, there are injuries to internal organs and the skeleton with the development of retroperitoneal hematoma and bleeding. The mortality rate in victims with injuries to retroperitoneal structures and pelvic organs reaches 60%. The presence of blood loss raises the question for surgeons and traumatologists of the need to provide emergency surgical care, the purpose of which is to stop bleeding and eliminate its consequences after injury.
Materials and methods. 114 victims (aged 19-70 years and older) with traumatic injuries of the pelvic organs and retroperitoneal space, accompanied by massive blood loss, who were treated in the traumatology department and the polytrauma department of the Kharkiv City Emergency Hospital named after Prof. O. I. Meshchaninov, as well as in the department of emergency surgery, traumatic shock, anesthesiology, resuscitation and intensive therapy of the State Institution «V. T. Zaitsev Institute of Internal Medicine of the National Academy of Sciences of Ukraine» were examined.
The results. Urgent examinations were performed on all victims. Radiological methods were used. Thus, with the help of a survey radiograph of the abdominal cavity, not only fractures of the pelvic bones were detected, but also the presence of free gas in the abdominal cavity and accumulation of gas in the retroperitoneal space, signs of retroperitoneal hematoma, deformation of the urinary bladder by retroperitoneal hematoma. Ultrasound helped to establish the presence of a massive retroperitoneal and paranephral hematoma.
Conclusions. The use of the balloon hemostasis technique to tem­porarily stop bleeding allows you to reduce the rate of blood loss, the growth of retroperitoneal hematoma, and prevent the development of purulent-septic complications, as well as improve the conditions for further assistance and the sequence of its implementation, depending on the extent of the injury.
FEATURES OF DIAGNOSTIC SURGICAL TREATMENT OF COMPLICATIONS OF NECROTIC PANCREATITIS
Authors: Boyko V. V. , Merkulov A. O. , Shevchenko A. M. , Tkach S. V. , Zelenova G. V. , Dogadailo O. I. , Radchenko M. V. , Voskresenska N. M. , Sydoriak A. V.
Published: February 2025

Summary. The aim of the study. On the basis of the conducted research, optimize the program of comprehensive diagnosis of complications of necrotic pancreatitis and the principles of surgical treatment of infected pancreatic necrosis.
Materials and methods. Analysis of diagnosis and treatment of 496 patients with acute pancreatitis was performed. Necrotic forms of purulent pancreatitis were diagnosed in 178 (35.9%) patients. Clinical, biochemical and bacteriological methods of laboratory diagnostics were carried out upon admission to the hospital and every 2-5 days depending on the severity of their condition. Ultrasound and endoscopic examination were performed for diagnostic and therapeutic purposes. X-ray diagnostic methods were widely used: X-ray of the stomach and duodenum with barium, fistulography, puncture pancreatocystography. Diagnostic scales were used to study the severity of the course of acute pancreatitis and the prognosis of the disease. The obtained data were processed using statistical methods.
Results. The use of modified surgical tactics in the treatment of infected forms of pancreatic necrosis made it possible to reduce postoperative mortality to 14.3%.
Conclusions. Indications for early surgical interventions in pancreatic necrosis are biliary pathology and the impossibility of excluding other acute pathology from the abdominal organs, as well as the progression of pancreatic necrosis with significant deterioration of the patient’s general condition.
The principle of surgical treatment of infected pancreatic necrosis is to perform surgical intervention in relatively late (more than 20 days from the onset of the disease), after suppression of the systemic inflammatory reaction and possible sequestration of necrosis centers.
In surgical treatment, the method of completing the operation for necrotic pancreatitis and its purulent-necrotic complications is closed lavage, which is more effective in the treatment of localized forms of purulent-necrotic pancreatitis; the method of programmed relaparotomy - for common forms of purulent complications of intra-abdominal localization and widespread purulent peritonitis; the method of treatment through a «controlled» laparostomy is effective in the treatment of large retroperitoneal phlegmons.
PREVENTION OF LOCAL HERNIOPLASTY COMPLICATIONS IN PATIENTS WITH LARGE VENTRAL HERNIAS DUE TO OBESITY
Authors: Kravets O. V. , Duzhyi I. D. , Piatykop Н. І. , Danylenko I. A. , Pak V. Ya.
Published: February 2025

Abstract. Aim. Study of the effectiveness of preventive measures in the development of wound complications of hernioplasty in patients with large ventral hernias who suffer from obesity.
Materials and methods. An analysis of the results of treatment of 365 patients with ventral hernias who had obesity of various degrees was carried out. Depending on the condition of the hernia gate, alloplasty was performed in one of three options: «Onlay», «Inlay» or «Sublay» with active drainage. A set of measures to prevent the development of local complications included lowering the body mass index; antibiotic prophylaxis of complications; intraoperative washing of the wound with antiseptic solutions; washing the wound through drainage with solutions of antiseptics; application of an elastic bandage.
The results. The use of preventive measures made it possible to reduce the number of complications by 9,3%. The greatest number of complications was observed in patients with III and IV degrees of obesity and in patients who underwent plastic surgery using the «Onlay» method.
Conclusions. Obesity is a risk factor for the development of postoperative complications in patients operated on for large ventral hernias. As the method of choice for operative treatment, it is recommended to use the «Sublay» technique. The use of a complex of preventive measures allows to reduce the frequency of local complications and reduce the length of stay of patients in the hospital.
LAPAROSCOPIC ROBOT-ASSISTED PROSTATECTOMY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA (LITERATURE REVIEW)
Authors: Horovyi V. I. , Shaprynskyi V. O. , Tserkovniuk R. G. , Sosnin M. D. , Kapshuk O. M. , Moraru-Burlesku R. P. , Dovgan I. I. , Balatskyi O. R. , Metashop O. S. , Taheiev V. R. , Livakovskyi S. K.
Published: February 2025

Annotation. The article presents a review of the literature over the past 15 years regarding the surgical treatment of patients with benign prostatic hyperplasia. It was established that during this period of time, new surgical methods of treating benign prostatic hyperplasia appeared in the arsenal of urologists, namely: laparoscopic and robot-assisted prostatectomy (including single-port). These minimally invasive operations dramatically reduced the percentage of open prostatectomies by reducing the number of intra- and postoperative complications, reoperations, postoperative bed days, and wound pain. Laparoscopic robot-assisted prostatectomy, when compared with laparoscopic prostatectomy, allows for better visualization of the operative field, greater volume and accuracy of instrument movements in hard-to-reach areas, less intraoperative blood loss and postoperative bed-day. The authors presented the methods and results of laparoscopic robot-assisted prostatectomy according to the literature in patients with benign prostatic hyperplasia. The introduction of robot-assisted prostatectomy will improve the results of treatment of patients with benign prostatic hyperplasia in Ukraine.
BREAST RECONSTRUCTION TRAM FLAP AFTER RADICAL MASTECTOMY (CLINICAL CASE)
Authors: Yevtushenko D. V. , Honcharova N. M. , Kolesnyk V. P. , Syvozhelizov A. V. , Kulish V. P. , Mykhaylik M. V. , Dniprovskyi A. S.
Published: February 2025

Summary. Approaches to the treatment of breast cancer were formed in proportion to the development of science and medicine and are still being improved. Today, it is generally known that treatment should be comprehensive, include methods of therapeutic measures depending on the characteristics of the disease in a particular patient, primarily on the form of growth and degree of tumor spread.
The goal is to improve the results of surgical treatment of patients with breast cancer.
Materials and methods. The article presents a clinical case from practice regarding the use of the TRAM Flap breast reconstruction technique after radical mastectomy.
Results and their discussion. Breast reconstruction after radical mastectomy is the optimal method for improving the quality of life of patients. A thorough preoperative examination provides surgeons with more detailed information about the site of future surgical intervention and minimizes the risks of such complications as ischemia and necrosis of the skin and subcutaneous muscle tissue.
Conclusions. According to the data of the study, it was found that the described surgical technique has positive results from a cosmetic point of view and the psychological state of the patient.
Gamified-Learning on enhancing English speaking skills among A1 learners at FineTuned English Language Institute, August 2024 to January 2025 Academic Period
Authors: Robles Juárez Ana Karen , Cango Patiño Adriana Elizabeth
Published: February 2025

This study analyzes the impact of gamified learning on the English oral proficiency development of A1 students at Fine-Tuned English Language Institute from August 2024 to January 2025. The study is focused on action research, and mixed methods approach, quantitative data from pre-and post-tests were combined with qualitative surveys. The sample included nine students aged eight to nine years, according to the Common European Framework of Reference (CEFR). The aim was to evaluate the effectiveness of gamified learning and to explore students' attitudes towards this methodology. The intervention followed Mertler's action research cycle, which is to plan, act, develop, reflect, and employ the Presentation, Practice, Production (PPP) methodology. The gamified activities were based on the second unit of the Fly Higher book published by Richmond ELT in 2022 and adapted to the student's level. The results showed significant improvements in fluency, grammar, vocabulary, and pronunciation. Finally, the study concludes that gamified learning is a dynamic and effective approach to improving speaking in EFL contexts, promoting a participatory environment that overcomes the limitations of traditional methods.
Incidencia de sobrepeso y obesidad en adolescentes en primer nivel de atención: sin relación con la funcionalidad familiar
Authors: Robles González Blanca Guadalupe , López Ramírez Lady Andrea , Martínez Hernández Jesús Francisco , Miranda Marín María del Rosario
Published: February 2025

Introducción: El sobrepeso y la obesidad es considerando un problema de salud pública, afectando a un 30% de la población, con consecuencias biológicas, sociales, culturales y económicas. Se ven afectadas por factores predisponentes como el sedentarismo, problemas psicológicos y estilos de vida poco saludables a nivel familiar. Objetivo general: Determinar la relación entre la funcionalidad familiar con el sobrepeso y la obesidad en adolescentes de 10 a 19 años de edad adscritos en la Unidad de Medicina Familiar No 23. Material y métodos: Se realizó un estudio de corte transversal, muestreo probabilístico aleatorio simple. Utilizando como herramienta el test FF-SIL, el análisis de datos se llevó a cabo mediante el cálculo de medidas de tendencia central y la construcción de tablas cruzadas.   Resultados: Se obtuvieron los datos de 335 pacientes, el 49.25% fueron hombres y 50.74% mujeres. El 84.17% padecían sobrepeso, 9.85% tuvo obesidad leve y 5.97% obesidad moderada. En funcionalidad familiar se encontró una media de 52.86 puntos. Fue más frecuente encontrar familias moderadamente funcionales con un 49.55%, seguido de familias funcionales en un 36.41%, disfuncionales en 13.73% y severamente disfuncionales en 0.29%. Conclusión: La expresión de afecto es un factor común en las familias moderadamente funcionales. Sin embargo, la falta de comunicación caracteriza a las familias severamente disfuncionales, lo que puede llevar a consecuencias negativas para sus miembros. Es fundamental ofrecer apoyo psicológico y terapia familiar, así como intensificar programas educativos para padres. De esta manera promover la adopción de estilos de vida saludables en las familias y mejorar su bienestar.
ESTRATÉGIAS PARA A IMPLANTAÇÃO EFETIVA DE SERVIÇOS DE FARMÁCIA HOSPITALAR NO CONTEXTO DO SISTEMA ÚNICO DE SAÚDE DO BRASIL
Authors: Novais Suelen da Rocha , Rodrigues Eder Pereira , Rodrigues Urbanir Santana , Rodrigues Gustavo Urbano Santana , Lima Claudia Feio da Maia , Machado Lucas Dias Soares , Praxedes Marcus Fernando da Silva
Published: February 2025

Introdução: A Farmácia Hospitalar (FH) é uma unidade clínica essencial para garantir o uso seguro e eficaz de medicamentos, desempenhando um papel crucial na gestão de cuidados em saúde. Objetivos: o presente estudo tem o objetivo de identificar estratégias eficazes para a implantação de serviços de FH no Sistema Único de Saúde (SUS) do Brasil. Metodologia: Revisão narrativa da literatura realizada na base de dados Biblioteca Virtual de Saúde, com o uso dos descritores em Ciências da Saúde:: "farmácia hospitalar" ("hospital pharmacy"), "implantação de serviços farmacêuticos" ("implementation of pharmaceutical services"), "gestão hospitalar" ("hospital management"), "efetividade dos serviços de farmácia" ("effectiveness of pharmacy services"), "integração multiprofissional" ("multidisciplinary integration") e "estratégias de implantação" ("implementation strategies"). publicados entre 2018 e 2024, A análise envolveu a avaliação descritiva, categorização e interpretação dos estudos selecionados, com foco nas práticas eficazes para a implementação desses serviços no Brasil. Resultados: Foram incluídos 15 artigos. Os resultados mostram que a presença do farmacêutico clínico contribui significativamente para a redução de problemas relacionados a medicamentos e a melhoria dos desfechos terapêuticos. Além disso, a adoção de tecnologias e sistemas de monitoramento é essencial para promover a eficiência e a qualidade da assistência farmacêutica. Conclui-se que, com um planejamento adequado e políticas públicas efetivas, a FH pode elevar a segurança do paciente e a eficácia dos tratamentos no SUS.
RELATO DE CASO - HÉRNIA DE PETERSEN
Authors: Guimbala Vitor Machado , Feitoza J.A , Neto Plinio Cezar , Ceribeli Daniel , Rodrigues Felippe Edson Fonseca
Published: February 2025

Paciente do sexo masculino, 30 anos, procura atendimento por queixa de dor abdominal difusa, tipo cólica, intermitente e intensa há 2 dias. Referiu que quadro álgico estava associado à parada de eliminação de flatos e fezes, nega febre. Paciente pós cirurgia bariátrica (by-pass gástrico) há 10 anos e pós colecistectomia, sem outras comorbidades.Tomografia de abdome evidenciou distensão difusa de todo o intestino delgado, nível hidroaéreo e provável hérnia interna. Abordagem cirúrgica de emergência foi realizada observando-se segmento de alça de delgado proximal (alça alimentar) com aproximadamente 40 cm de elemento herniário trombosado, sem sinais de perfuração, distando 5 cm do Y de Roux. Presença de moderada quantidade de líquido serohemático em cavidade. Sendo realizado enterectomia segmentar de segmento trombosado com anastomose laterolateral. Discussão: As hérnias internas são complicações comuns em pacientes pós-bariátricos por bypass gástrico. Apesar da recomendação de realizar o fechamento de espaço de Petersen no intraoperatório, ainda há incidência de hérnia no seguimento de médio e longo prazo. Novas alternativas como a sutura de jejuno no mesocólon transverso ou uso de clipes para servir como método para facilitar o diagnóstico precoce. Considerações finais: A hérnia de Petersen é uma complicação comum em pacientes pós-bariátricos por bypass gástrico em Y-de-Roux. Trata-se de um quadro que necessita de diagnóstico e abordagem precoce, pois implica diretamente na morbimortalidade e no desfecho do paciente conforme a evolução do quadro, sendo assim, necessita constar como um diagnóstico diferencial importante a ser considerado pelo cirurgião.
INFECÇÃO URINÁRIA NA GESTAÇÃO: UMA ANÁLISE DA ASSOCIAÇÃO COM A PREMATURIDADE.
Authors: Sousa João Lucas Moita de , Magalhães Rebeca de Sena , Ruberto Vitor Saymon Nascimento , Costa Luis Gustavo de Oliveira , Bernardes Gabriel Parente , Silva Thiago Pinheiro da , Santos Monique Vitória de Oliveira , Duarte Yasmin Raiana Viana dos Anjos , Macedo Caroline Gomes , Macedo Ana Emília Gomes
Published: February 2025

Objetivo: Investigar fatores de associação entre a Infecção do Trato Urinário (ITU) e o parto prematuro. Métodos: Trata-se de uma revisão integrativa qualitativa que promoveu um estudo transversal com corte entre janeiro de 2019 a dezembro de 2023 por meio de artigos selecionados para focar na robustez e qualidade das informações. Resultados: Estudos mostram que existem fatores de riscos frequentes quando se trata da infecção do trato urinário gestacional, sendo os principais: baixo nível econômico, higiene insatisfatória, baixo nível educacional, recorrência de ITU e imunossupressão seja por doenças crônicas (diabetes, câncer etc.) e uso de drogas (maconha, cocaína, álcool). Além disso, verificou-se a ausência de conduta específica para detecção e tratamento da ITU com idade gestacional baixa. Conclusão: Conclui-se que os principais fatores como ITU recorrente, tabagismo, idade materna e a demora para diagnóstico e tratamento de ITU devem ser imediatamente correlacionados à ruptura de membrana prematura, cabendo o rastreio, detecção e sensibilidade para manejo adequado.
INNOVACIÓN Y EQUIDAD EN PROGRAMAS SOCIALES: IMPACTO EN LA NUTRICIÓN Y BIENESTAR EN HUÁNUCO, PERÚ
Authors: Barrón Herrera Mijel , Bazán Tanchiva Luis Javier , Chávez Díaz Jorge Miguel , Bazán Tanchiva José Antonio
Published: February 2025

El estudio estuvo vinculado con el Objetivo de Desarrollo Sostenible ODS 2; que pretende eliminar el hambre, garantizar la seguridad alimentaria, optimizar la nutrición y promover una agricultura sostenible. Un programa de complementación alimentaria bien gestionado es clave para alcanzar esta meta, ya que garantiza que los alimentos lleguen a las poblaciones más vulnerables, asegurando una distribución equitativa y adecuada de recursos. Este estudio tuvo como objetivo determinar de qué manera la gestión de programa de complementación alimentaria influye en la satisfacción de los beneficiarios de un distrito de Huacaybamba, Huánuco, 2024. La metodología fue de tipo básica, con un enfoque cuantitativo, el diseño no experimental, transversal, de nivel correlacional - causal y de método hipotético-deductivo. Se aplicó la encuesta como técnica, y como instrumento el cuestionario. La población fue de 100 beneficiarios; y la muestra de 80 beneficiarios. Se obtuvo como resultados, el valor de Chi-cuadrado es 2855,029 con un valor de Sig. de 0,001; el valor de Nagelkerke en un 99,9%; y las estimaciones de parámetros de Wald de 17,697; se concluyó que la gestión de programa de complementación alimentaria influye positivamente en la satisfacción de los beneficiarios de un distrito de Huacaybamba, Huánuco, 2024.
LESÕES MÚSCULO-ESQUELÉTICAS RELACIONADAS COM O TRABALHO EM PROFISSIONAIS DE SAÚDE: EPIDEMIOLOGIA, CARACTERIZAÇÃO E AVALIAÇÃO
Authors: COSTA J.F. , Prazeres Virgínia Maria Pereira , Rodrigues Tânia Marisa Pinto
Published: February 2025

O capítulo aborda as Lesões Músculo-Esqueléticas Relacionadas com o Trabalho em profissionais de saúde, destacando a sua epidemiologia, caracterização e avaliação. Estas lesões são uma das principais causas de absentismo laboral e perda de produtividade, afetando significativamente áreas como músculos, tendões, ligamentos e nervos devido a atividades repetitivas e condições ergonómicas inadequadas. Os profissionais de saúde, especialmente os enfermeiros, são particularmente vulneráveis devido à natureza física das suas funções, como o levantar e transferir pacientes, sendo a dor lombar o sintoma mais comum, seguido de dores no pescoço, ombros e joelhos. A "epidemia" de Lesões Músculo-Esqueléticas Relacionadas com o Trabalho na Europa afeta milhões de trabalhadores, traduzindo-se em altos custos para as Organizações, com cerca de 67% das doenças profissionais em Portugal a serem atribuídas a estas lesões. O capítulo destaca a importância de identificar padrões comuns e fatores de risco para desenvolver intervenções preventivas eficazes. Para a avaliação das Lesões Músculo-Esqueléticas Relacionadas com o Trabalho, são utilizados instrumentos como o Questionário Nórdico Músculo-esquelético (QNM) e o Índice MAPO, que ajudam a mapear os fatores de risco e a desenvolver estratégias de intervenção. Em resumo, o capítulo sublinha a necessidade de melhorar as condições de trabalho e implementar medidas preventivas para criar um ambiente de trabalho mais seguro e saudável.
PERFIL E CONHECIMENTO DE GESTANTES SOBRE DIABETES MELLITUS GESTACIONAL E SEUS FATORES DE RISCO
Authors: Miranda Michele Calori Correia Azevedo , Pereira Mariane Carolina de Souza , Marçal João Bueno , Gomes Lilian Cristiane
Published: February 2025

Objetivo: Descrever o perfil e o conhecimento de gestantes sobre diabetes mellitus gestacional e seus fatores de risco. Métodos: Estudo transversal, descritivo e de abordagem quantitativa, desenvolvido em uma amostra de 30 gestantes em acompanhamento de pré-natal em uma unidade ambulatorial de um município do interior mineiro, no ano de 2023. A coleta de dados foi por meio de entrevista individual, com a aplicação de instrumento semiestruturado. Resultados: Houve maior frequência de mulheres solteiras, média de idade inferior a 30 anos, com média escolaridade e renda familiar média próxima a dois salários mínimos; 56,7% estavam entre a segunda e a quinta gestações, com idade gestacional de 21 semanas ou mais (53,3%), tendo iniciado o pré-natal com até 10 semanas (80%) e realizado pelo menos seis consultas (63,3%). A maioria negava o diagnóstico de diabetes gestacional (86,6%) e/ou comorbidades (70%), mas referiu histórico familiar da doença (76,7%); houve desconhecimento acerca do diabetes gestacional, suas complicações e fatores de risco. Conclusão: É fundamental a implementação e/ou expansão de intervenções educativas que possam promover maior conhecimento e engajamento das gestantes em comportamentos saudáveis, com vistas a reduzir os fatores de risco e a possibilidade de desfechos perinatais desfavoráveis.
FATORES DE RISCO, TERAPIAS E IMPACTOS DOS TRANSTORNOS DE ANSIEDADE NA PRIMEIRA INFÂNCIA: UMA REVISÃO DE LITERATURA
Authors: Barbalho Samuel Mariano de Magalhães , Carvalho Elena Ribeiro Guerra , Queiroz Mariana Stela Oliveira , Oliveira Valdemir Teixeira de
Published: February 2025

Introdução:Os transtornos de ansiedade na primeira infância são condições prevalentes que afetam o desenvolvimento emocional, social e cognitivo das crianças. Fatores genéticos, neurobiológicos e ambientais contribuem para sua manifestação, enquanto intervenções comportamentais, como a terapia cognitivo-comportamental (TCC) e a terapia de interação pai-filho, têm demonstrado eficácia no manejo.Objetivo:Avaliar os fatores de risco, abordagens terapêuticas e impactos psicossociais dos transtornos de ansiedade na primeira infância, destacando estratégias eficazes e identificando lacunas no cuidado.Metodologia:Foi realizada uma revisão de literatura qualitativa e exploratória, analisando 12 artigos publicados entre 2023 e 2024. Os temas foram categorizados em fatores de risco, terapias comportamentais, tratamento farmacológico, impactos psicossociais e disparidades regionais.Resultados:Os fatores de risco incluem influências genéticas, eventos estressantes precoces e estilos parentais controladores. As terapias comportamentais, especialmente a TCC, mostraram-se eficazes no manejo da ansiedade. Tratamentos farmacológicos são indicados apenas para casos graves, devido a preocupações com efeitos colaterais. A ansiedade não tratada está associada a dificuldades psicossociais e acadêmicas, reforçando a necessidade de intervenções precoces.Conclusão:Os transtornos de ansiedade na primeira infância exigem intervenções integrativas e personalizadas, considerando tanto fatores biológicos quanto psicossociais. Futuros estudos devem explorar abordagens terapêuticas mais equitativas e adaptadas às realidades culturais e regionais.
Pengembangan Media Pembelajaran Interaktif Berbasis Website Menggunakan Goggle Sites Pada Materi Sistem Komputer di SMA Negeri 1 Tapa
Authors: Abdari Vikky Alamsyah , Hadjaratie Lillyan , Dwinanto Arif , Pakaya Nikmasari , Pakaya Jemmy A. , Bau Rahmat Taufik R. L
Published: February 2025

Penelitian ini bertujuan untuk mengetahui hasil pengembangan media pembelajaran berbasis website menggunakan Google Sites pada materi Sistem Komputer kelas X di SMA Negeri 1 Tapa memenuhi kriteri valid dan kriteria praktis. RD atau Research and Development merupakan metode yang digunakan dalam penelitian ini dengan menggunakan ADDIE (Analysis, Design, Development, Implementation, Evaluation) sebagai model penelitian. Hasil dari penelitian dengan melakukan uji validitas media, ahli materi dan praktikalitas. Uji validitas media memperoleh hasil sebesar 94,15% dengan kategori “sangat valid” untuk ahli materi memperoleh hasil sebesar 93,33% dengan kategori “sangat valid” dan untuk uji praktikalitas memperoleh hasil sebesar 93,12% rata – rata presentase yang dalam hal ini termasuk ke dalam kategori “sangat praktis”.  Berdasarkan hasil tersebut dapat disimpulkan bahwa media pembelajaran berbasis website menggunakan Google Sites pada materi sistem komputer di SMA negeri 1 tapa praktis dan valid untuk menjadi media yang digunakan untuk kebutuhan pembelajaran.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA MATERI KONSEP DAN KEBUTUHAN SISTEM BERORIENTASI OBJEK
Authors: Umar Brahmantio Putra , Suhada Sitti , Bouty Abd Aziz , Hadjaratie Lillyan , Dai Roviana H. , Dwinanto Arif , Mas’ud Huzaima
Published: February 2025

Pada observasi awal ditemukan permasalahan pada proses pembelajaran materi konsep dan kebutuhan sistem berorientasi objek, guru hanya mengandalkan media utama seperti buku cetak sehingga menyampaikan materi kurang efektif dan didapati nilai ulangan harian siswa di bawah dari KKM ( Kriteria Ketuntasan Minimal ). Penelitian ini bertujuan untuk mengembangkan media pembelajaran berbasis android pada materi Konsep dan Kebutuhan Sistem Berorientasi Objek dan mengetahui kelayakan dari media pembelajaran berbasis android yang dikembangkan. Pada penelitian ini menggunakan metode penelitian dan pengembangan dengan model pengembangan Four-D (4D). Terdapat 4 tahapan dalam model pengembangan (Four-D) 4D, yaitu : define (Pendefinisian), design (Perancangan), develop (Pengembangan), dan disseminate (Penyebaran). Hasil Penelitian ini pada uji kelayakan ahli media mendapatkan rata-rata persentase 93,75% dengan kategori sangat layak, dan pada uji kelayakan ahli materi mendapatkan rata-rata persentase 91,66% dengan kategori sangat layak. Selain itu, pada uji respon siswa mendapatkan rata-rata persentase 90,09%. Berdasarkan hasil penelitian tersebut maka dapat simpulkan bahwa media pembelajaran yang telah dikembangkan valid dan sangat layak untuk digunakan dalam proses pembelajaran.
REVIEW OF IOT SUBJECT: TREND AND CHALLENGE FOR RESEARCH AND PUBLICATION
Authors: Nadifa Ulfatun , Mohamad Yasin , Asmara Bambang Panji , H Haeriani , Ode Asri Aristi Ayuningsi , Dongka Rahmat Hidayat , Ashari Sri Ayu , Saputra Wahyu , Mutmainnah Nur
Published: February 2025

The Internet of Things (IoT) has emerged as a transformative technology that is revolutionizing various industries and everyday life. This study aims to explore current trends and challenges in IoT research and publication. The research method employed in this study begins with a blind search across various international journal databases, followed by ranking the minimum and maximum percentages of each IoT subject. The journal databases used include IEEE, Science Direct, Taylor and Francis, and NATURE. Subjects with minimal rankings or IoT journal topics with the lowest percentages in each database were then reviewed based on predetermined filters. The blind search results revealed that IoT subjects with the lowest percentages were IoT Smart Farming at 0.87%, IoT Smart Bin at 1.54%, and IoT Smart Water at 2.73%. A review was subsequently conducted on journals covering IoT subjects to identify trends and challenges related to techniques, tools, and objects in the subjects with the lowest percentages.
Pengaruh Kinerja Perusahaan Dan Pertumbuhan Penjualan Terhadap Penghindaran Pajak: Peran Moderasi Direksi Wanita
Authors: Fanetha Nathania , Oktavini Eva
Published: February 2025

Tujuan dilakukannya penelitian ini adalah untuk mengetahui peran moderasi direksi wanita pada penghindaran pajak yang dipengaruhi oleh kinerja perusahaan dan pertumbuhan penjualan. Pemilihan sampel dengan metode purposive sampling. Pada penelitian ini digunakan model regresi linier berganda dengan menggunakan Stata 17. Sampel penelitian adalah 234 data perusahaan sektor consumer non-cyclicals yang tercatat di Bursa Efek Indonesia periode 2020 – 2022. Hasil penelitian ini menunjukkan bahwa kinerja perusahaan berpengaruh negatif signifikan terhadap penghindaran pajak yang berarti semakin baik kinerja perusahaan maka tindakan penghindaran pajak juga menurun sedangkan pertumbuhan penjualan berpengaruh positif signifikan terhadap penghindaran pajak yang berarti semakin tinggi tingkat pertumbuhan penjualan maka semakin tinggi tindakan penghindaran pajak. Direksi wanita tidak dapat memoderasi hubungan kinerja perusahaan dan pertumbuhan penjualan terhadap penghindaran pajak hal ini dikarenakan proporsi direksi wanita yang masih minim dan kedudukan direksi wanita belum mendominasi.
Pengaruh Penerimaan BPHTB dan PBB Terhadap Pendapatan Asli Daerah Kota Tomohon
Authors: Tala Olifia Yodiawati , Sumual Frida Magda , Rawung Laura Theresia
Published: February 2025

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh Bea Perolehan Hak Atas Tanah dan Bangunan dan Pajak Bumi dan Bangunan secara parsial dan simultan terhadap Pendapatan Asli Daerah Kota Tomohon selama periode 2020–2023. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan data sekunder dari hasil Laporan Realisasi Anggaran Pemerintah Kota Tomohon tahun 2021 – 2023. Teknik pengambilan sampel menggunakan sampling jenuh yaitu realisasi Pendapatan asli daerah (PAD), Bea Perolehan Hak atas Tanah dan Bangunan (BPHTB) dan Pajak Bumi dan Bangunan (PBB) di Kota Tomohon selama tahun 2021-2023 dengan total sampel yaitu 36. Hasil penelitian ini menunjukkan bahwa Bea Perolehan Hak Atas Tanah dan Bangunan (BPHTB) tidak berpengaruh terhadap Pendapatan Asli Daerah secara parsial, kemudian Pajak Bumi dan Bangunan berpengaruh positif dan signifikan terhadap Pendapatan Asli Daerah, dan secara simultan Bea Perolehan Hak Atas Tanah dan Bangunan (BPHTB) dan Pajak Bumi dan Bangunan berpengaruh signifikan terhadap Pendapatan Asli Daerah. Dengan hasil penelitian ini maka berimplikasi pada Badan Pengelolaan Keuangan dan Pendapatan daerah Kota Tomohon mendapat manfaat besar dari penggunaan Bea Perolehan Hak Atas Tanah dan Bangunan (BPHTB) dan Pajak Bumi dan Bangunan secara bersamaan.
Pengaruh Struktur Modal Dan Profitabilitas Terhadap Nilai Perusahaan
Authors: Ayahu Elsanti , Amaliah Tri Handayani , Mahmud Muliyani
Published: February 2025

Penelitian ini bertujuan untuk menguji pengaruh struktur modal dan profitabilitas terhadap nilai perusahaan pada perusahaan subsektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia periode 2016-2021. Metode penelitian yang digunakan adalah metode penelitian kuantitatif deskriptif statistik. Jenis data yang digunakan adalah data sekunder yaitu data berdasarkan laporan keuangan Tahun 2016-2021 yang diperoleh melalui situs www.idx.co.id. Metode pengambilan sampel dengan menggunakan purposive sampling diperoleh 8 perusahaan dengan menggunakan analisis regresi berganda. Hasil penelitian menunjukan bahwa Struktur Modal berpengaruh negatif dan signifikan terhadap Nilai Perusahaan pada Perusahaan manufaktur sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2021. Profitabilitas berpengaruh positif dan signifikan terhadap Nilai Perusahaan pada Perusahaan manufaktur sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2021. Secara simultan Struktur Modal dan Profitabilitas berpengaruh signifikan terhadap nilai perusahaan pada Perusahaan manufaktur sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2021.
Penerapan Konsep Entitas dalam Mengidentifikasi Perkembangan Usaha Mikro Sektor Barang Ritel di Kecamatan Kabila Bone Kabupaten Bone Bolango
Authors: Monoarfa Amelia Ramadhani , Tuli Hartati , Lukum Amir
Published: February 2025

Penelitian ini bertujuan untuk mengetahui penerapan konsep entitas dalam mengidentifikasi perkembangan usaha mikro di Kecamatan Kabila Bone Kabupaten Bone Bolango. Penelitian menggunakan pendekatan analisis deskriptif. Sampel dalam penelitian ini sebanyak 31 orang. Pengumpulan data menggunakan kuesioner Teknik analisis data menggunakan analisis deskriptif dan uji instrumen. Hasil Penelitian menunjukkan bahwa responden dewasa dan lansia, serta mereka dengan tingkat pendidikan yang lebih tinggi, lebih efektif dalam menerapkan prinsip entitas. Pengalaman dan pendidikan formal terbukti berhubungan positif dengan kemampuan pengelolaan keuangan yang lebih baik. Selain itu, usaha yang telah berdiri lebih lama menunjukkan praktik pengelolaan keuangan yang lebih matang. Penelitian ini menegaskan pentingnya penerapan prinsip entitas dalam pengelolaan keuangan untuk mencapai pertumbuhan usaha mikro yang berkelanjutan.