bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Acupressure at Neiguan (P6) Point on Nausea and Vomiting During Early Pregnancy
Authors: Tariq Maria , Nayyer Uzma , Hassan Sana , Khan Sara Jamil , Yousaf Aisha , Malik Maryum Noor
Published: January 2025

Objective: This study investigates the effectiveness of acupressure at Neiguan Pericardium 6 (P6) point using Psi-Bands on severity of pregnancy-related nausea and vomiting, comparing the results with those of a placebo group.
Methodology: This randomized, placebo-controlled trial, 40 pregnant females experiencing mild to moderate levels of nausea and vomiting before 20 weeks of gestation were allocated into two groups equally (n=20). Pregnant females were recruited between April and June 2024 from Islamabad Diagnostic Centre (IDC), and Executive Clinics of IDC in Islamabad, Pakistan. In acupressure group, pressure was exerted on P6 point using a Psi-Band knob/button for 3 days, while in placebo group, the Psi-Band was worn without applying pressure to P6 point. Frequency and severity of nausea and vomiting were documented twice daily for 1 week, with intervention commencing on 4th day. ANOVA, Mann-Whitney U test, and Fisher's exact tests were employed for data analysis.
Results: The mean women age was 26.3±5.3 years. After three days of intervention, acupressure group showed a substantial decrease in nausea duration, frequency, and severity, as well as in vomiting frequency, compared to placebo group (p < 0.05). After intervention, acupressure and placebo groups showed a substantial difference in frequency and severity of nausea (p < 0.05), but insignificant difference was seen in duration of nausea or frequency of vomiting (p > 0.05).
Conclusion: Applying acupressure at P6 point using a wristband for at least 3 days seems to effectively relieve pregnancy-related nausea and vomiting. This effect may partially result from placebo effect.
pilares uexküllianos de Sebeok: Umwelt como modelo semiósico de lo real (o sobre el idealismo de la biosemiótica)
Authors: Bastard Rico Juan Alberto
Published: January 2025

Thomas Sebeok es reconocido por ser el principal fundador de la biosemiótica, doctrina interdisciplinaria en la que la semiótica y la biología se cruzan para comprender a los vivientes como seres de semiosis, es decir, capaces de producir e interpretar signos. De acuerdo con sus afirmaciones, su proyecto teórico se sostiene principalmente sobre dos pilares: la semiótica de Charles Sanders Pierce y la biología de Jakob von Uexküll. No obstante, esto no excluye otras influencias, como la de uno de los hijos de Uexküll, Thure. En esto texto se explora esta línea de influencia teórica en la obra sebeokena, esto es, la de los dos Uexküll. Por un lado, la doctrina del mundo circundante (Umweltlehre) de Jakob le permite a Sebeok comenzar a comprender procesos semiósicos no verbales más allá de lo humano, en plantas y animales. Por otro lado, la propuesta endosemiótica de Thure, que ve en la célula la unidad mínima de semiosis, le ayuda a Sebeok a extender el campo de estudio de la biosemiótica a todo lo vivo. Con ello, Sebeok logra comprender finalmente los mundos circundantes de los seres vivos como modelos semiósicos de lo real, esto es, como modelos fenoménicos y significativos constituidos subjetivamente por medio de signos. Esto implica la asunción de tesis idealistas, heredadas del trascendentalismo kantiano, que implican algunas consecuencias filosóficas que se analizan hacia el final del trabajo.
Students’ “Communication skill” Training Preferences at Dr. Rajendra Prasad Central Agricultural University, India
Authors: Sikdar Samrat , Prakash Satya
Published: January 2025

The study attempted to explore the preferences of the students enrolled in a Central Agricultural University of India (Dr. Rajendra Prasad Central Agricultural University) regarding future communication skills training programs from their placement point during 2024. Soft skills (especially the professional communication skills) have become one of the mandatory criteria for placement in contemporary India. It is quite insufficient to secure a job only based on the hard skills or knowledge as achieved throughout the degree program. This issue has received a tremendous attention by the different educational institutions in agriculture and allied sectors. 100 students from RPCAU were the respondents of this study, and they were asked to indicate their preferences regarding the future professional communication skills training sessions as conducted by the university’s placement cell. The students indicated their preferences regarding content, venue and duration of the future trainings, training participants’ size, time of the trainings, various methods used during those trainings, trainer types etc. The comprehensive view of the students’ preferences regarding the future soft skills trainings and this research study will be highly beneficial for the university administrators to sketch out the roadmap for future professional skills development trainings for the university students.
Development of Media Package for Creating Awareness among Rural Women Regarding use of Aloe vera
Authors: Mahal Parneet , Kaur Kanwaljit , Sharma Mandeep
Published: January 2025

To check the effectiveness of developed media package on Aloe vera, a sample of 130 rural women from 13 villages of Ludhiana district was purposively selected. The data were collected in April and May 2024 from Ludhiana district and were analyzed with the help of percentage, mean score and paired t-test. The media package containing printed material, WhatsApp messages and video clips on Aloe vera was developed and validated by 30 Subject Matter Specialists. Effectiveness of media package was measured in terms of mean change in health benefit, its nutritive value and usage into different forms for curing various ailments and awareness level of the respondents after the exposure of the media package. Interview schedule was constructed to collect data into two phases. Before exposure to media package data regarding status of growing and awareness level of Aloe vera plant. Printed materials related to plant were distributed to the respondents. WhatsApp message and video clips were sent to the rural women. After 25 days post awareness data were collected. Results of the study showed significant change between pre and post awareness mean score for its all parameters. So, the prepared media package was proved to be effective to motivate people.
Global Research Trends in Family Farming: A Bibliometric Insight
Authors: Suman Swati , Prusty Ajay Kumar , Deb Atanu , Kumari Alka , Reddy G Sriker
Published: January 2025

Family farming is considered as most sustainable form of agriculture, which is accepted worldwide. It is integral to food production, rural livelihood and cultural heritage. The concept of family farming changed significantly over time. The study utilizes the bibliometric analysis approach to examine the dynamic concept of family farming in the agricultural sector over the decade. The data is extracted from the Scopus database from 2015-2024 and analysed using bibliometric tools such as R Studio and VOSviewer. The study presents a thorough and measurable evaluation of the contributions from different countries, keyword frequencies and research trends with thematic evolution, offering a more empirical knowledge of the subject. The study investigates that the research has increasingly emphasized integrated and sustainable practices such as agroecology, gender role in farming and rural development policies. This shift reflects a growing recognition of family farming’s role in promoting sustainable agriculture, addressing global challenges and shaping a food-secure future for generations to come. To advance this crucial area of research, researchers, policymakers, and family farmers themselves must continue to work together.
Analyzing Perception and Hesitation in the Context of Home Science Career Aspirations
Authors: Kriti Komal , Singh Aarti , Yadav Akansha , Anshu Anshu
Published: January 2025

Home science, despite its rich potential for addressing contemporary societal needs, faces hesitation among prospective students as a viable career option. The study conducted in 2024 on 50 students from several Home Science Educational Institutions. This study adopted a descriptive approach, using structured close-ended questionnaires through quantitative analysis involving interviews and surveys to collect information. This study explored the relationship between students’ perceptions of home science as a career option and the factors contributing to their hesitancy in pursuing it. A chi-square analysis was conducted. The findings indicated that stereotypes, peer influence, and confusion about career pathways significantly impact students’ perceptions, contributing to hesitation in choosing home science. Conversely, gender bias, limited career knowledge, uncertainty about job opportunities, and lack of family support did not show significant relationships with students’ perceptions, indicating that these factors were less influential in their decision to consider home science as a viable career option. These findings highlighted the importance of addressing stereotypes and peer pressure while providing clearer career pathways to improve the perception of home science. The study suggested that targeted interventions in these areas could encourage more students to view home science as a rewarding and viable career choice.
Evaluating the Performance of Cluster Frontline Demonstration (CFLD) on Mustard in North Bengal
Authors: Sarkar Sujit , Padaria R N , Burman R R , Gurung Natasha , Barma Pranab
Published: January 2025

The production and productivity of mustard in terai and dooars region of North Bengal was comparatively low than national and state average, and farmers were still following decade old varieties and traditional practices. Hence, IARI regional station-Kalimpong promoted advance mustard varieties like PM 30, PM 26 and Pusa Vijay in the region through 600 CFLDs in 6 blocks of Jalpaiguri, Kalimpong and Darjeeling district in North Bengal. The demonstrations were conducted in five consecutive rabi seasons from 2019- 2023 and their performance were assessed each year against the control variety. The study used a mix of control- treatment and before-after experimental research design. The findings revealed that the maximum yield was recorded in Pusa Vijay (18.60 q/ha) followed by PM 26 (17.30 q/ha) and PM 30 (13.80 q/ha). The Pusa Vijay reported yield advantage of 48.92 per cent followed by PM 26 (45.09%) and PM-30 (31.16%). The study proved the effectiveness of CFLD in speedy outspread of suggested technologies of mustard horizontally among the farming communities. So, it is recommended that policy bodies should come up with sufficient financial support to frontline extension system for conducting CFLD under the guidance of scientists and extension professionals.
Cluster Analysis-Based Discernment of Farmers’ Typologies and Climate Change Adaptation Strategies among Rural Women
Authors: Pundir Simran , Padaria R N , Muralikrishnan L , Aiswarya S , Mukherjee Sweety , Shravani Kotha , Ghosh Bhaskar
Published: January 2025

Climate change poses significant challenges to agriculture, particularly in vulnerable regions like Uttar Pradesh and Haryana, where women contribute significantly to the agricultural workforce. They play a pivotal role in adopting climate-smart adaptation strategies ensuring food security, economic stability, and environmental sustainability. The study was conducted in 2024 to explore women farmers ‘adaptation strategies using K-means clustering. Based on their prioritization of 16 strategies, randomly selected 100 women farmers were found to belong in four distinct clusters. Cluster 1 emphasized crop and agronomic practices, changing planting dates, crop rotations, and Direct Seeded Rice (DSR). Cluster 2 prioritized mechanization and technology integration, raised-bed planting and laser levelling. Cluster 3 focused on soil and water management and harvesting practices, zero tillage, crop diversification, while Cluster 4 preferred sustainable practices as mulching, Integrated Pest Management (IPM), and bio-fertilizers. The analysis underscores the need for targeted agricultural and extension interventions tailored to each cluster’s unique priorities. Strategies include promoting climate-resilient crops, precision agriculture, conservation techniques, and bio-inputs. Extension approaches such as field demonstrations, custom hiring centers, and capacity-building workshops are recommended. These findings highlight importance of cluster-specific strategies to empower women farmers and enhance their resilience to climate change, contributing to sustainable development goals.
Knowledge Gap and Path Analysis of Adoption of Makhana (Euryale Ferox Salisb) Growers in Bihar
Authors: Kumar Sonu , Jha K K
Published: January 2025

This study examined the knowledge gap and adoption of the improved makhana cultivation technology in Bihar. The research utilized a descriptive research design and focused on four districts viz. Purnia, Katihar, Darbhanga, and Madhubani. During 2022–24, eight villages were purposively selected from these blocks which included Pipra and Birpur from Purnea block, Mirzapur and Lachhmipur from Barari block, Ballupur and Kishunpur from Bhadurpur block, and Chanuraganj and Simra from Jhanjharpur block. The study included 120 sample, with fifteen makhana growing farmers randomly chosen from each of the eight villages. The findings revealed that plant protection component (disease and pest control) had the highest mean knowledge gap (61.88%), with a relatively low knowledge index of 24.10, and adoption index of 19.33. Further technology adoption and knowledge level of farmers had positive and significant association with landholding size, annual income, income from makhana and training exposure. Improvement in information dissemination on latest technical knowhow via focused campaigns and farmer engagement activities through need based trainings is crucial for increasing the adoption of improved makhana cultivation technology among the farmers for enhanced productivity and profitability.
Evaluation of the Prevalence of congenitally permanent tooth agenesis among pediatric patients in the subregion of Antalya
Authors: BALLI AKGÖL Beyza , KIRZIOĞLU ERCAN Rukiye Gözde , BAYRAM Merve
Published: January 2025

Aim: This research aimed to ascertain the prevalence of congenitally permanent teeth agenesis, excluding third molars, among children residing in the subregion of Antalya, Turkey.
Material and Methods: A retrospective evaluation of panoramic radiographs from 3234 children (1567 females, 1667 males) aged 6 to 12 years was conducted. Participants with systemic illnesses, extracted teeth, ongoing orthodontic interventions, and congenital abnormalities were excluded. Chi-square test and One Sample Chi-square test were employed for comparing qualitative data.
Results: The study cohort exhibited a mean age of 9.02±1.99 years. The prevalence of congenitally permanent teeth agenesis was determined to be 1.9%, with a distribution of 2.3% among females and 1.6% among males, although no statistically significant disparity was observed between genders (p>0.05). Notably, a statistically significant difference in the occurrence of tooth agenesis was noted among the jaws (p<0.05), with a notably higher incidence observed in the mandibular region compared to the maxillary region (p<0.05). Mandibular second premolars represented the most frequently absent teeth, accounting for 77.9% of cases, a finding deemed statistically significant (p<0.05). Additionally, maxillary second premolars exhibited a notable prevalence of 15%, a proportion significantly higher than that observed for maxillary lateral incisors, mandibular lateral incisors, mandibular central incisors, and left mandibular first premolars (p<0.05).
Conclusion: The prevalence of congenitally teeth agenesis varies across populations. Timely and accurate diagnosis of agenesis of permanent teeth is essential to facilitate the development of a comprehensive long-term treatment strategy and improve prognostic outcomes in affected individuals.
Investigation of Readability and Quality Levels of Online Patient Information Texts Related to Jaw Cysts
Authors: DOLUNAY Uğur , KÜÇÜKKOLBAŞI Hasan , AKDOĞAN Yunus
Published: January 2025

Aim: The internet is frequently utilized as a resource for accessing health-related information, contributing significantly to health literacy. With the proliferation of internet usage, it has become evident that the majority of hospitals maintain websites, which serve as platforms for disseminating information to individuals regarding healthcare professionals, medical conditions, and treatment options. This study aims to assess the readability and quality of patient information texts about jaw cysts available on the internet.
Materials and Methods: In May 2023, patient information texts relating to "jaw cysts" from 62 out of the initial 120 websites retrieved through the Google search engine (Google LLC, Mountain View, California, USA) were assessed for readability and quality. Readability levels of the texts were determined using the "ARI(ARI)", while the quality assessment was conducted utilizing the DISCERN scale. Statistical analysis was performed using SPSS 23 (SPSS Inc., Chicago, IL, USA).
Results: According to the ARI, 50% (31 websites) of the patient information texts available on the internet were assessed at the 11-12 grade level, with 85.5% (53 websites) categorized as of medium difficulty. Additionally, based on the DISCERN scale assessment, 46.7% (29 websites) of the texts were rated as poor in quality.
Conclusion: In the creation of patient information texts concerning jaw cysts on the internet, it is imperative to take into account our society's health literacy levels. There is a pressing need for the development of higher quality and more readable texts to effectively disseminate information to the public.
FSUE “NAMI” work on reduction of complex urban air pollution with hazardous substances caused by vehicle operation
Authors: Azarov V. K. , Pervushin M. A. , Kutenev V. F.
Published: January 2025

The paper contains materials from the first studies of the problem of urban air pollution caused by vehicle operation to the United Nations (UN) Regulations being developed over the last 70 years. It also analyzes the materials of studies by NAMI experts, who significantly contributed to the issue of reducing urban air pollution during vehicle operation.
Analysis of possibilities and prospects of application of artificial intelligence technology in automotive design
Authors: Ivchenko V. I. , Pavlovich D. V. , Moysey O. N. , Bokhonko V. V.
Published: January 2025

Introduction (problem statement and relevance). Industrial and, in particular, automotive design are effective tools in positioning a product in the market and drawing purchaser’s attention. That is why it is vital to seek and test new methods and means aimed at enhancing designer capacities, improving the quality of their work results, reducing the development time and costs. One of the promising focus areas to improve the design process is the use of artificial intelligence (AI) capabilities. This raises the task of studying the world’s best practices in this area.

The purpose of the study is to determine the possibilities, development trends and prospects of application of AI technology when vehicle styling design developing and their practical application testing.

Methodology and research methods. Methods of analysis and systematization of results of research works in the area of application of AI technology in design have been used; an experiment on their practical application has been conducted.

Scientific novelty and results. An analytical review of research works on development, testing and application of algorithms, trainable models of systems and software programs using AI technology in vehicle designing has been carried out. Systems with machine learning tools ensuring generation of realistic images of vehicles and their components, creation and testing of styling design according to the set aesthetic and engineering criteria, assessment of the degree of similarity of the designs, software programs with integrated CAD/CAE systems have been reviewed. Results of testing of the process of creation of vehicle render images with the use of AI-powered software Vizcom have been presented.

Practical significance. Application of AI technology in vehicle styling design ensures faster search for design ideas, higher quality of images received, and extended possibilities of variable presentation of the initial design concept.
Analysis of the anti-lock braking system efficiency when applying the PID control algorithm and fuzzy logic
Authors: Nguen Chong Dyk , Karpukhin K. E. , Vu Khay Kuan , Nguen Khak Min’ , Nguen Van Khung
Published: January 2025

Introduction (problem statement and relevance). The braking system in a vehicle plays an extremely important role. Modern braking system technologies have been constantly improved throughout the history of the automotive industry development. Today, anti-lock braking system (ABS) are widely used and are standard for motor vehicles around the world. Methods to control the braking system in order to optimize the braking process efficiency have been studied by many scientists. This article investigates and develops a simulation model using digital technologies for evaluation of the braking system efficiency applying a number of different control methods.

The purpose of the study is to investigate the ABS efficiency when using different control methods by means of a number of operation efficiency evaluation indicators: braking time, braking distance, etc. The article represents three different control methods along with a detailed evaluation and selection of the most efficient one.

Methodology and research methods. The methods used in this study are based on the fundamental principles of the vehicle theory. The braking system characteristics are analyzed in detail in four ABS-related cases by means of development and application of two control algorithms: PID control and fuzzy logic.

Scientific novelty and results. The research results for the four cases show that the efficiency of the braking system when using the PID control method with the braking distance criterion has better results – 27.59% – compared to a braking system without ABS. The PID control method considered in the article gives the best results when studying braking systems with ABS on vehicles.

Practical significance. The results are based on application of different control methods in order to make optimal decisions to improve the efficiency of vehicle braking system use with a view to increase the vehicle safety level.
An Overview of New Oral Anticoagulant Toxicity
Authors: Çelik Kamuran , Elumar Funda
Published: January 2025

Extended life expectancy, changes in dietary habits, and a sedentary lifestyle have contributed to an increased risk of stroke and myocardial infarction. Atherosclerosis and thrombosis are the underlying causes of stroke and myocardial infarction. Anticoagulants have a significant role in both the prevention and treatment of these conditions. The difficulty of monitoring warfarin derivatives, which have been in use until recently, and their narrow therapeutic range paved the way for the development and use of new oral anticoagulants. Rivaroxaban, Apixaban, Edoxaban, and Betrixaban are Factor Xa inhibitors, while Dabigatran is a Thrombin (FIIa) inhibitor, and together they comprise the new oral anticoagulants. It is crucial to manage any accidental or intentional overdose with these new oral anticoagulants. The present review focuses on the characteristics of novel anticoagulants and their toxicological management.
Advancements in brain organoid models for neurodegenerative disease research
Authors: Park Soomin , Park Jong-Chan
Published: January 2025

Neurodegenerative diseases (NDs) such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are progressive disorders characterized by complex, human-specific pathology that poses challenges to drug discovery efforts. Traditional models, including two-dimensional cell cultures and animal models, often fall short in replicating the intricate cellular interactions observed in human neurodegeneration. This review explores the potential of brain organoid technology to address these limitations and offer a model more relevant to humans. Recent advancements in induced pluripotent stem cell (iPSC) technology have enabled the generation of patient-derived brain organoids that differentiate into various neural cell types within 3-dimensional structures. These iPSC-derived brain organoids establish a physiologically relevant microenvironment that mimics human brain architecture and cellular diversity. This review synthesizes studies on the application of brain organoids in modeling PD and AD pathology, including approaches to improve model fidelity. Brain organoids replicate disease-specific features, including dopaminergic neuron degeneration in PD and amyloid plaque formation in AD, offering valuable insights into disease mechanisms and potential therapeutic targets. However, challenges remain, including incomplete maturation, batch variability, and the absence of vascularization and complete cortical layering. Bioengineering approaches, including CRISPR-based gene editing and organ-on-a-chip technologies, are being investigated to overcome these obstacles. Brain organoid technology presents a transformative platform for the study of NDs, facilitating detailed research into disease mechanisms and testing of therapeutics. Overcoming existing challenges is crucial for maximizing the translational value of brain organoids, advancing personalized medicine, and supporting the development of effective therapies for NDs.
Influência da Reputação Corporativa e do Comportamento Corporativo Responsável no Desempenho de Mercado
Authors: Kisata Lauriany , Mazzioni Sady , Soschinski Caroline Keidann , Rosa Fabricia Silva da
Published: January 2025

Objetivo: Avaliar o efeito interativo da reputação corporativa e do comportamento corporativo responsável no desempenho de mercado em companhias abertas listadas na B3.
Método: Pesquisa quantitativa, com uso de regressão por mínimos quadrados ordinários (MQO). A amostra compreendeu 84 empresas listadas na B3, resultando em 504 observações correspondentes ao período de 2016 a 2021.
Resultados: Empresas com maior reputação corporativa, possuem maior índice de market-to-book e preço/lucro. No que concerne à influência do comportamento corporativo responsável, constatou-se que empresas com maior escore ESG e que adotam os ODS em seus relatórios de sustentabilidade, possuem maior índice market-to-book. Quanto ao efeito interativo, os resultados apontaram interatividade apenas entre a reputação corporativa e as práticas ESG com o índice market-to-book.
Originalidade/Relevância: O estudo amplia evidências sobre as implicações dos distintos fatores do comportamento corporativo responsável e da reputação corporativa, tanto de modo individual quanto interativo, sobre o desempenho de mercado das empresas. Considera diferentes proxies para comportamento corporativo responsável, que capturam perspectivas complementares acerca do desempenho de mercado das empresas brasileiras.
Contribuições Teóricas/Metodológicas: A pesquisa contribui ao demonstrar que o investimento em práticas responsáveis e em reputação corporativa induzem a criação de valor para as empresas, que são percebidas pelos investidores como mais atrativas. Adicionalmente, demonstra que a boa reputação corporativa gera expectativas mais elevadas do mercado sobre tais empresas, impulsionando o crescimento no preço das ações.
Fatores econômicos, financeiros e características que influenciam a Tempestividade da Informação Contábil do setor público nos municípios de Minas Gerais
Authors: Cirino Andréia Lopes , Araújo Juliana Maria de , Pereira Nathália Amaral , Junior Antonio Carlos Brunozi , Ferreira Marco Aurelio Marques
Published: January 2025

Objetivo: a presente pesquisa tem como objetivo compreender os elementos que influenciam na tempestividade da homologação dos Relatórios Resumidos de Execução Orçamentária (RREO).
Método: foram coletados dados financeiros, demográficos e de acesso à internet dos 853 municípios do estado de Minas Gerais. Os dados foram tratados através da regressão para dados de contagem utilizando o modelo Binomial Negativo.
Resultados: os resultados demonstram que as receitas correntes e os gatos públicos com pessoal, educação, saúde e segurança influenciam positivamente na tempestividade da homologação dos RREO.
Originalidade: Embora a tempestividade possibilite que os dados informados sejam disponibilizados em tempo hábil para influenciarem na tomada de decisão, a literatura ainda é escassa ao desvelar os aspectos que influenciam na tempestividade do setor público.
Contribuições teóricas/metodológicas: A contabilidade não é muito empregada como objeto de análise pela Teoria dos Stakeholders, mesmo as partes interessadas sendo frequentemente abordadas nas publicações contábeis. A literatura ainda carece de investigações mais aprofundadas sobre o tema, especialmente em contextos municipais.
Contribuições sociais/para a gestão: Este estudo oferece evidências sobre como os maiores investimentos realizados em educação, saúde e segurança, bem como o fluxo financeiro de receita corrente e o gasto com o pessoal tendem a influenciar para uma maior tempestividade.
KARAKTERISASI DAN SKRINING FITOKIMIA EKSTRAK BUNGA TELANG (Clitoria ternatea L.)
Authors: Rismayuti Bebie Ayu , Risa Supriningrum  , Supomo
Published: January 2025

Characterization is a step to determine the quality of an extract of natural materials, which includes specific, non-specific parameters, and phytochemical screening. This study aims to determine the specific, non-specific characteristics and secondary metabolite compounds of telang flower extract. Telang flowers are made into powdered simplisia, and the drying shrinkage is determined. Furthermore, extraction was carried out using the maceration method with 70% ethanol solvent. The drying shrinkage of the simplisia was 10% and the extract yield was 43.8%. Specific characterization results include organoleptic observations in the form of thick blue-black extract with a distinctive odor and bitter taste. The average content of soluble compounds in water is 58% and the average content of soluble compounds in ethanol is 17.67%. Non-specific characterization results include an average moisture content of 21.93%. Average ash content of 5% and acid insoluble ash content of 2%. The average specific gravity was 1.015 g/ml and the results of mold/chamir numbers were 1 × 102 colonies/g and total plate numbers were 1.3 × 103 colonies/g. Secondary metabolite compounds contained in telang flower extract include alkaloids, flavonoids, saponins, steroids and terpenoids.
Effect of interest rate and inflation on investment in Nigeria, 1981-2023
Authors: Metieh, Felix Chukwuka  , Mgbomene, Chukunalu
Published: January 2025

This research focused on the effect of interest rate and inflation on investment in Nigeria. Empirical evidence suggested that there has been little attention linking interest rate, inflation rate and investment in contemporary economic literature especially using other varieties of interest rates such as prime lending rate and savings rate. This research formulated three objectives which include: to determine the relationship between prime lending rate and investment, ascertain the relationship between inflation rate and total investment; and investigate the extent to which savings rate affect total investment in Nigeria. Data were sourced from central bank of Nigeria statistical bulletin and analyzed using error correction model. The result revealed that there was a significantly negative relationship between prime lending rate and total investment, inflation rate decreased total investment significantly and that savings rate had positive effect on total investment in Nigeria but the positive effect was not statistically significant. The conclusion was that prime lending rate and inflation rate have been detrimental to investment in Nigeria and as a result, it was recommended that savings rate and prime lending rate should be maintained to a stable state in order to encourage investment outlay in Nigeria.
 Keywords: Inflation Rate, Interest Rate, Investment, Prime Lending Rate, Savings Rate.
Aplicações da Inteligência Artificial na Bioinformática: Avanços, Possibilidades e Limites Morais
Authors: Neto Aristóteles Góes , Camargo Thiago Miguelito Navarro de
Published: January 2025

Inteligência Artificial (IA) compreende um campo de conhecimento transdisciplinar (abrangendo Ciências Exatas, Ciências da Vida e Humanidades como campos basilares) cujo objetivo é criar sistemas capazes de realizar tarefas que, quando realizadas por seres humanos, tendem geralmente a ser associadas com inteligência [1]. Entretanto, inteligência é um termo atrelado a um conceito abstrato, complexo e razoavelmente complicado de, inclusive, ser adequadamente definido, pois está muito impregnado por uma visão fortemente antropocêntrica. Antropocentricamente definida, inteligência compreenderia raciocínio e capacidade de resolução de problemas, bem como todos os conceitos diretamente acoplados a esses atributos, como, por exemplo, capacidade lógica, compreensão, raciocínio, planejamento, criatividade e pensamento crítico. Todavia, adotando uma visão mais ampla e geral, e dentro de um arcabouço biológico e, consequentemente, evolutivo, inteligência pode ser entendida como: (i) percepção de informações, (ii) retenção como conhecimento (memória) e (iii) aplicação desse conhecimento por comportamentos adaptativos em um determinado contexto (ambiente). Dessa forma, escapa-se da visão antropocêntrica forte, dominante em todas as Ciências Sociais e Humanas, contextualizando-a em toda a dimensão biológica [5].
Interactoma vírus-hospedeiro: como montá-lo?
Authors: Carvalho Lucas Miguel de
Published: January 2025

Este artigo tem como objetivo a construção e análise de um interactoma vírus-hospedeiro utilizando dados de interação proteína-proteína. Inicialmente, extraímos da literatura as interações entre as proteínas do SARS-CoV-2 e suas proteínas humanas correspondentes. Posteriormente, essas interações foram enriquecidas com o interactoma humano completo, obtido a partir do banco de dados BIOGRID, adicionando uma camada de complexidade ao modelo. Após a construção do interactoma viral, por meio de um procedimento detalhado no software Cytoscape, realizamos uma análise de enriquecimento funcional das proteínas humanas que interagem com a proteína S do vírus, utilizando a ferramenta Enrichr e a base de dados WikiPathways 2024. Esse processo visa identificar as principais vias biológicas envolvidas na infecção viral. Além disso, exploramos análises adicionais que podem ser realizadas a partir do interactoma completo, como a identificação de genes hub, os quais desempenham papéis cruciais no controle da rede de interações. A integração entre o interactoma específico do vírus e o interactoma humano completo proporciona uma visão mais ampla das consequências da infecção viral nas redes proteicas humanas, oferecendo insights fundamentais para o desenvolvimento de estratégias terapêuticas mais eficazes.
Kandungan gula total, karbohidrat, dan organoleptik sportfood berbahan dasar semangka kuning (Citrullus lanatus (Thunb.) Matsum.&Nakai) dan pisang raja (Musa acuminata x Musa balbisiana)
Authors: Farida Farida , Triastanti Resti Kurnia
Published: January 2025

Latar belakang: Pisang raja merupakan sumber karbohidrat dan kalium, sementara semangka kuning kaya dengan karbohidrat, kalium, dan sitrulin. Karbohidrat merupakan zat gizi makro yang memiliki peranan penting dalam mendukung performa atlet, dengan menyediakan energi yang siap pakai. Pangan olahraga dengan kandungan gula yang tinggi dalam berbagai sediaan sesuai untuk dikonsumsi sebelum, saat, dan setelah olahraga.  
Tujuan penelitian: Tujuan dari penelitian ini adalah untuk menentukan bentu sediaan yang paling disukai konsumen dengan tetap memiliki kandungan gula dan karbohidrat yang optimal.
Metode penelitian: Desain penelitian ini adalah true experiment dengan satu faktor. Faktor merupakan bentuk sediaan yang terbagi menjadi jus, jus saring buang ampas, dan gel. Produk dicobakan pada panelis tidak terlatih, kemudian dianalisis kandungan gula total dan karbohidrat.
Hasil: Nilai efektifitas menunjukkan bahwa dari hasil uji organoleptik aspek rasa, aroma, tekstur, dan warna, sediaan yang paling disukai adalah gel, meski pada aspek aroma dan warna tidak menunjukkan perbedaan yang signifikan. Kandungan gula total pada gel menunjukkan nilai tertinggi dibanding dua sediaan lainnya yaitu 1,58 g/100 g. Gel juga memiliki kandungan karbohidrat tertinggi yakni 12,39%.
Simpulan: Kesimpulan penelitian ini adalah sediaan bentuk gel merupakan bentuk sediaan yang paling optimal baik dari aspek organoleptik maupun kandungan gula total dan karbohidrat.
NEUROCIÊNCIA E ENSINO DE MATEMÁTICA COM JOGOS DIGITAIS
Authors: Benício de Sá Gilmara , Silva Anderson José , Rodrigues Eder Lino , Silva Evaneide Rocha da , Santos Francisco José dos , Silva José Marcos de Souza , Teixeira Maria Lúcia Lima Diógenes , Silva Neto Raimundo Cazuza da , Cruz William Figueredo
Published: January 2025

Este estudo investigou como os conhecimentos da neurociência poderiam ser aplicados no contexto educacional por meio do uso de tecnologias educacionais, visando otimizar os processos de aprendizagem. O problema central da pesquisa foi entender como as descobertas neurocientíficas podem ser integradas ao ensino por meio de tecnologias, com foco na personalização e eficácia do aprendizado. O objetivo geral foi analisar como essas contribuições da neurociência podem orientar o uso das tecnologias educacionais para melhorar a aprendizagem. A metodologia adotada foi bibliográfica, com análise de obras acadêmicas e artigos científicos sobre neurociência, educação e tecnologias. O desenvolvimento abordou a relação entre os processos cognitivos estudados pela neurociência e as tecnologias educacionais, destacando como plataformas digitais e inteligência artificial podem personalizar o ensino e contribuir para a inclusão de alunos com dificuldades de aprendizagem. Além disso, a pesquisa destacou a importância de um uso equilibrado das tecnologias, garantindo que elas complementem as interações humanas. As considerações finais apontaram que a integração entre neurociência e tecnologias educacionais oferece um grande potencial para aprimorar o ensino, mas também sugeriram a necessidade de estudos empíricos para avaliar o impacto real dessas ferramentas no ambiente escolar. A pesquisa contribuiu para a compreensão de como essas áreas podem se complementar na prática pedagógica.
Agitated Americans
Authors: Ahern Patrick
Published: January 2025

Not long after the so-called “statist” model of national identity was perceived to be waning with increasing globalization of power, the reactionary rise of authoritarian populist movements proliferated, promoting provincial and xenophobic outlooks. This ‘pathic nationalism’ has been promoted by the affective appeal of so-called ‘agitators’ who draw upon a shared sense of grievance, and rather than turning towards the sources of their frustration or offering a vision for its relief, only deepen submission to the current conditions. Though one could argue that anti-democratic and outright authoritarian impulses lie underneath nationalistic tendencies, these elements are brought to the fore in the pathic version of nationalism where the veneer of civil pride is undergirded by both a reified notion of “the people” and an affective aggressiveness toward an out-group. In this context, nationalistic impulses such as those found in the current expression of white and/or Christian nationalism in the United States entail a significant threat to the development and sustenance of a democratically organized society. In this essay, I explore the lessons of the early Frankfurt School, most notably by Theodor Adorno and Leo Lowenthal, for understanding the appeal and dangers of authoritarian populist agitators for the current development of an American national identity.
Pengembangan Media Pembelajaran Vidio Animasi Berbasis Aplikasi Canva Pada Materi IPAS Bagian Tubuh Tumbuhan Kelas IV SDN 10 Muara Sugihan
Authors: Khanifah Niken Asih , Arni Yusni , Pratiwi Marina , Anggrina Ulan Despi
Published: January 2025

Learning media is a component that has an important role in the implementation of learning. The problems that are often encountered are the lack of use of learning media during learning and also the use of learning resources which is still lacking (Ergantara & Sari, 2023). This research aims to develop animated video learning media based on the Canva application on science content material on plant body parts for class IV SDN 10 Muara Sugihan. The lack of learning media that attracts students' interest is the impetus for conducting this research. Students have characters who enjoy playing games, watching YouTube, TikTok and even making TikTok. The solution that educators can take is to introduce animated videos into the learning process. The aim of this research is to produce animated video learning media that is valid, practical and effective. This research uses the Research and Development (R&D) research method with a 4-D paradigm consisting of the stages of definition, design, development and distribution.
Meri Zaat Zarra-e-Benishan: A Tale of Resistance and Resilience in the Face of Patriarchy and Misogyny-A Foucauldian Discourse Analysis
Authors: Ghilzai Shazia Akbar , Khanam Tahira , Fatima Anbarin
Published: January 2025

This Study applies FDA (Foucauldian discourse analysis) to study how female characters resist patriarchy and misogyny in the novel “Meri Zaat Zarra-e-Benishan”. This novel is suitable for exploring female subject’s resistance because it is a true depiction of a typical patriarchal Pakistani society. This study focuses on the central ideas of FDA: power, resistance and agency. Throughout the novel protagonist Saba resists patriarchal power structures and female misogyny. She refuses to accept anything that male or female members chooses for her. She actively negotiates her position within her community. Through Saba's story, we see how both male and female misogynists can be equally damaging to women's progress, and the fight for equality. The protagonist journey is characterized by a strong sense autonomy, self-respect and self-reliance.  She encounters gender based prejudices but resists actively to establish her point of view. It illustrates effectively that Pakistani women are capable of resisting repressive power structures. The findings support Foucault’s view which suggests that power circulates within the society and a powerful subject is not all powerful, conversely a weak subject is not all powerless. Rather subjects negotiate their position in everyday interactions. The subjects who are at weak positions also exhibit power which they exert through resisting powerful structures.
ANALYSIS OF ARTIFICIAL INTELLIGENCE MODELS FOR PREDICTING VICAT TEMPERATURE OF VARIOUS COMPOUNDS BASED ON BIOHDPE COMPARING DIFFERENT MACHINE LEARNING TECHNIQUES
Authors: Llorca Alcón Manuel , GARCIA SANGUERA DAVID , LINARES PELLICER JORDI
Published: January 2025

Materials science is an interdisciplinary field that studies the structure, properties, behavior, and performance of materials. This work focuses on polyethylene polymers, the most widely used in the industry, with a particular emphasis on bio-polyethylenes, which align with sustainability goals by being derived from renewable materials such as biomass and agricultural crops, reducing dependence on fossil resources and minimizing the carbon footprint.
The VICAT temperature is a key measure for evaluating the thermal resistance of thermoplastic materials, indicating the temperature at which they begin to soften under load. A higher VICAT temperature suggests better resistance to thermal deformation. A BioHDPE matrix, known for its high impact and tensile strength, suitable for demanding applications, was used.
To improve mechanical and thermal properties, hemp fibers, almond powder, argan powder, and Halloysite nanotubes (HNT) were incorporated into the matrix, using organic waste to reduce costs. These components, available in the Mediterranean region, affect the VICAT temperature differently: hemp fiber and HNT enhance mechanical strength, while almond and argan powders may reduce it due to their tendency to decompose.
Machine learning (ML) techniques were applied to predict the VICAT temperature, aiming to reduce time and costs in the development of new materials. Regression models, including Multiple Linear Regression (MLR), Neural Networks (NN), Decision Trees (DT), and k-Nearest Neighbors (kNN), were compared, evaluated using the Mean Absolute Percentage Error (MAPE) and the coefficient of determination (R²). The best ML model was identified by a low MAPE and high R², ensuring high prediction accuracy.
This study demonstrates the potential of ML in predicting material properties, contributing to the efficient and sustainable design of new polymers.

Keywords: BioHDPE, Machine Learning, VICAT Temperature, Neural Networks, Prediction
LATTICE STRUCTURES GRADING FOR STIFFNESS OPTIMIZATION: AN APPROACH BASED ON TOPOLOGY OPTIMIZATION FOR PARTS MANUFACTURED VIA MULTI JET FUSION
Authors: INNOCENTI ALESSANDRO , MORENO NIETO DANIEL , BORGIANNI YURI , SALES LERIDA DAVID , MOLINA RUBIO SERGIO IGNACIO
Published: January 2025

The rapid advancement of additive manufacturing (AM) technology and computational design techniques has unveiled a promising synergy between these two fields. The high print resolution achievable nowadays enables the pro-duction of intricate shapes, such as lattice structures, which can be further opti-mized through simulation-driven design techniques such as topology optimization (TO). This paper presents an optimization workflow that leverages field-driven design to employ the results of a TO to locally vary the diameter of lattice struc-tures, aiming for weight reduction and stiffness maximization. The process in-volves the automation of nTop design software via Python scripts to systemati-cally evaluate design variants and identify optimal solutions. The workflow steps are demonstrated through the application to a connecting rod and conclude with the evaluation of the achieved mechanical performance of the optimized compo-nent via Finite Element Method (FEM) analysis.
Keywords: Additive Manufacturing, Topology Optimization, Lattice Structures, Field-Driven Design, Finite Element Method.