bluuebunny/crossref_metadata_2025 huggingface dataset:
The reporting quality of the interventional animal experiments in Chinese journals-based on the evaluated results of the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines
Authors: Ma Bin , Zhao Bing , Jiang Yanbiao , Zhang Ting , Shang Zhizhong , Zhang Weiyi , Hu Kaiyan , Chen Fei , Mei Fan , Gao Qianqian , Zhao Li , Kwong Joey S.W.
Published: February 2020

Objective To evaluate retrospectively the reporting quality of animal experiments published in Chinese journals adhering to the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines. Methods We searched databases including CNKI, WanFang, VIP and CBM by July, 2018. Two well-trained reviewers screened and extracted articles independently. The ARRIVE guidelines were used to assess the quality of animal experiment reports. The compliance rate of every item was analyzed according to different published time.Results 4342 studies were included finally, of which 73.03% had been cited ≤ 5 times, only 29.04% (1261/4342) were published in journals of Chinese Science Citation Database. The assessment results showed that the compliance rate of more than half of sub-items (51.28%, 20/39) was less than 50% and 65.00% (13/20) of sub-items was less than 10%.Conclusion The reporting quality of animal experiments in Chinese journals is generally lower than moderate level. Along with the publication of the ARRIVE guidelines in 2010, the compliance rate of most items in the ARRIVE guidelines has been improved to some extent. However, some specific items of methods, results and discussion were not still reported sufficiently and integrally. Therefore, it is necessary to popularize the ARRIVE guidelines, advocate researchers to adhere to the ARRIVE guidelines in the future and especially to promote the use of the ARRIVE guidelines in specialized journals, so as to promote the design, implementation and reporting of animal experiments, and ultimately improve their quality.
Improving the usefulness of evidence concerning the effectiveness of implementation strategies for knowledge products in primary healthcare: Protocol for a series of systematic reviews
Authors: Zomahoun Hervé Tchala Vignon , Massougbodji José , Bussières André , Thomas Aliki , Kairy Dahlia , Uwizeye Claude Bernard , Rheault Nathalie , Charif Ali Ben , Diendéré Ella , Langlois Léa , Tchoubi Sébastien , Gaye Serigne Abib , Légaré France
Published: February 2020

Background : The literature on the implementation of knowledge products is extensive. However, this literature is still difficult to interpret for policymakers and other stakeholders when faced with choosing implementation strategies likely to bring about successful change in their health systems. This work has the particularity to examine the scope of this literature, and to clarify the effectiveness of implementation strategies for different knowledge products. Consequently, we aim to: 1) determine the strengths and weaknesses of existing literature overviews; 2) produce a detailed portrait of the literature on implementation strategies for various knowledge products; and 3) assess the effectiveness of implementation strategies for each knowledge product identified and classify them. Methods : We will use a three-phase approach consisting of a critical analysis of existing literature overviews, a systematic review of systematic reviews, and a series of systematic reviews and meta-analyses. We will follow the Cochrane Methodology for each of three phases. Our eligibility criteria are defined following a PICOS approach: Population , individuals or stakeholders participating in healthcare delivery, specifically, healthcare providers, caregivers, and end users; I ntervention, any type of strategy aiming to implement a knowledge product including, but not limited to, a decision support tool, a clinical practice guideline, a policy brief, or a decision-making tool, a one-pager, or a health intervention; Comparison, any comparator will be considered; Outcomes, Phases 1 and 2 – any outcome related to implementation strategies including, but not limited to, the measures of adherence/fidelity to the use of knowledge products, their acceptability, adoption, appropriateness, feasibility, adaptability, implementation costs, penetration/reach and sustainability; Phase 3 – any additional outcome related to patients (psychosocial, health behavioral, and clinical outcomes) or healthcare professionals (behavioral and performance outcomes); Setting , primary healthcare has to be covered. For each phase, two reviewers will independently perform the selection of studies, data extraction, and assess their methodological quality. We will analyze extracted data, and perform narrative syntheses and meta-analyses when possible. Discussion : Our results could inform not only the overviews’ methodology, but also the development of an online platform for the implementation strategies of knowledge products. This platform could be useful for stakeholders in implementation science.
The CXCL12/CXCR4 signaling is required for DPP4 regulation of spontaneous inhibitory postsynaptic currents (sIPSCs)
Authors: Zhang Yusong , Chen Zhiguo , Yang Zhishan , Han Yadi
Published: February 2020

Background: Previous data suggested that dipeptidyl peptidase-IV (DPP4) involved in the occurrence of febrile seizure (FS), but its potential mechanism remains to be determined. Here, we investigated whether DPP4 regulated gamma-aminobutyric acid (GABA) mediated spontaneous inhibitory postsynaptic currents (sIPSCs) via the downstream C-X-C Motif Chemokine Ligand 12 (CXCL12)/ C-X-C chemokine receptor type 4 (CXCR4) signaling in cultured hippocampal neurons submitted to hyperthermia(39.5-40°C). Methods: Whole cell patch- clamp method was used to test sIPSC in vitro after DPP4 inhibition or CXCL12 administration. The level of CXCL12 and CXCR4 was tested using western blot analysis. The effect of CXCR4 antagonist AMD3100 (5 mg/ml, i.c.v) on seizures were tested using electroencephalogram (EEG) in a FS model. Results: We found that pharmacological DPP4 inhibitor sitagliptin (Sita,100μM) treatment or siRNA-mediated DPP4 knockdown enhanced the mean amplitude and frequency of sIPSCs in vitro. DPP4 knockdown with siRNA increased protein level of CXCL12 and CXCR4. Furthermore, CXCL12 (10 nM) treatment enhanced inhibitory transmission by increasing the mean frequency and amplitude of sIPSCs in vitro. AMD3100 administration decreased seizure severity by increasing hippocampal GABA content in vivo. Conclusions: Our data suggest that CXCL12/CXCR4 signaling is required for DPP4 regulation of sIPSCs, supporting that DPP4 played a key role in the pathogenesis of FS.
Knowledge, attitude and practice of Sri Lankan women towards breast cancer: A cross sectional study
Authors: Ranaweera N.D. , Dinesha P.M.C. , Pathirage C.A.K. , Weerasinghe P.W.D.N. , Senarathna D.M.K.N. , Ariyasena G.A.G.M.S. , Galgamuwa G.L.S. , Wijesiri H.S.M.S.K. , Balawardhana K.A.S.J.
Published: February 2020

Introduction Breast cancer is a type of cancer that develops from breast tissue. Although the knowledge on breast cancer among women in Sri Lanka is high, their practice of breast self-examination is poor. This study was aimed to determine attitudes, practices and the awareness of early detection techniques and risk factors among women in Sri Lanka. Method A study was conducted between two groups in National Cancer hospital, Sri Lanka and a peripheral women clinic consisting 317 participants in each group. Self-administered questionnaire was used to collect data regarding the awareness of early detection techniques, signs and symptoms and risk factors for breast cancers. Results A total of 33.8% of peripheral women clinic and 65.0% in National Cancer hospital patients had good knowledge regarding risk factors. The knowledge of risk factors, signs and symptoms and screening methods about breast cancers was significantly high in patients attending to National cancer hospital. Older aged people have less awareness about screening methods compared to younger people. People with high education background and those have a family history of breast cancer had more aware about screening and therapeutic methods. Conclusion Comparative to the peripheral women clinic, patients attending to National Cancer Hospital had a fairly good knowledge, practice and attitude regarding the early detection techniques, risk factors, signs and symptoms.
TMEM100 negatively regulated by microRNA-106b facilitates cellular apoptosis by repressing survivin expression in NSCLC
Authors: Ma Jun , Yan Tingting , Bai Yongrui , Ye Ming , Ma Xiumei , Wu Jihong , Zhang Lei
Published: February 2020

Background Non-small-cell lung cancer (NSCLC) is a common malignant tumor. Nevertheless, the 5-year survival rate of NSCLC patients remains poor. Thus, finding critical factors involved in regulating the progression of NSCLC is important for providing potential treatment targets. Methods CCK-8, colony formation, caspase-3 activity, luciferase reporter assay, and western blot assays were utilized in this study. Results We found that TMEM100 was significantly downregulated in NSCLC tissues compared with paired peritumoral tissues. Decreased TMEM100 expression was associated with poor clinical outcomes in NSCLC patients. Moreover, TMEM100 overexpression inhibited colony formation and facilitated apoptosis via repressing survivin expression in NSCLC cells, whereas TMEM100 knockdown had the opposite effect. In addition, miR-106b, a microRNA with controversial roles in different human cancers, was upregulated in NSCLC and directly downregulated TMEM100 expression. The roles of miR-106b in cell survival were mitigated by the restoration of TMEM100. Conclusions The above results indicate that TMEM100 induces cell apoptosis and inhibits cell survival by serving as a tumor suppressor and that miR-106b-degraded TMEM100 expression defines a potentially oncogenic pathway in NSCLC.
Klotho Deficiency Aggravated Diabetes-induced Podocyte injury
Authors: Chen Zhi , Zhou Qing , Liu Cong , Zeng Yiping , Yuan Shaolong
Published: February 2020

Background: Diabetic nephropathy (DN) is a progressive disease, the main pathogeny of which is podocyte injury inducing glomerular filtration barrier and proteinuria. The occurrence and development of DN could be partly attributed to the reactive oxygen species (ROS) generated by mitochondria. However, researches on how mitochondrial dysfunction (MtD) ultimately causes DNA damage is poor.Methods: We generated streptozotocin (STZ)-induced diabetic mice with wild-type(C57BL/6J) or Klotho deficiency mice (KL+/-) and treated podocytes with high glucose (HG) to investigated the function of Klotho on HG-induced podocyte injury in vivo and in vitro.Results: The absence of Klotho aggravated diabetic phenotypes indicated by podocyte injury accompanied by elevated urea albumin creatinine ratio (UACR), creatinine, urea nitrogen. Then, Klotho deficiency could significantly aggravate DNA damage by increasing 8-OHdG and reducing OGG1. Finally, Klotho deficiency may promote MtD to promote 8-OHdG-induced podocyte injury.Conclusions: Klotho deficiency may promote diabetes-induced podocytic MtD and aggravate 8-OHdG-induced DNA damage by affecting OOG1.
Antibiotic Resistance Profile of Bacteria Isolated from Wastewater Systems in Eastern Ethiopia
Authors: Ayele Awugchew Teshome , Alemayehu Tadesse , Ayele Yohanis , Serda Biresaw , Marami Dadi , Busa Nigusie
Published: February 2020

Background : Antimicrobial resistance is one of the major public health challenges in the 21st century. In response, World Health Organizations launched a global action plan on antimicrobial resistance since 2015, which is, along with other objectives, aimed to strengthen knowledge of the spread of Antimicrobial resistance through surveillance and research. As wastewater systems are important reservoirs of communal human and animal bacteria, antibiotic residue and resistance genes they are considered as surveillance hotspots. Objective : To assess the antibiotic resistance profile of proposed environmental resistance indicator bacteria in selected wastewater systems of Eastern Ethiopia from Feb. 2018 to Oct. 2019. Method : Three wastewater management systems in Eastern Ethiopia, such as the activated sludge system of Dire Dawa University, waste stabilization pond of Haramaya University and a septic tank of Hiwot Fana Specialized University Hospital were monitored by sampled quarterly over 18 months. A total of 66 samples was collected from 11 sampling locations and a total of 722 Escherichia coli (151), Aeromonas spp. (142), P. aeruginosa (143), E. faecalis (144), and E. faecium (142) were isolated using selective culture media and biochemical tests. Their antimicrobial susceptibility was tested using standard Kirby-Bauer disk diffusion method on the surface of the Mueller-Hinton agar and the result was interpreted according to EUCAST guidelines. Multiple Antibiotic Resistance Index (MARI) was calculated for each isolate and its change in the course of treatment was evaluated. Result : The highest percentage of resistance was seen for ampicillin among isolates of hospital wastewater effluent which is 36(94.7%), 33(91.7%) and 32(88.9%) for E. coli, E. faecalis, and E. faecium respectively. Lower rate of resistance was seen isolates from activated sludge system and gentamicin for isolates of activated sludge wastewater treatment system which is 10(16.4%), 8(13.3%), 11(18.9%), and 12(20.3%) for E. coli, E. faecalis, E. faecium , and P. aeruginosa respectively. MERI value was found to be variable across monitored sites and the course of the wastewater treatment process. Conclusion : The study has found a high level of environmental antibiotic resistance indicator bacteria thrive in the wastewater systems most of which were multi-resistant. Hospital wastewater exhibits higher resistance than the other two wastewater systems. The multi-drug resistance index has significantly increased in the course of the wastewater treatment process, indicating the possible proliferation of resistance in the wastewater treatment system.
INNOVATIVE METHODS OF PROMOTION OF RETAIL TRADE ENTERPRISES
Authors: Saher L. , Lazorenko V.
Published: February 2020

The high level of competition in retail makes the market participants constantly seek new tools to fight for the consumer and his means. One such tool is promotion. At the same time, the use of outdated technologies can not guarantee success. Accordingly, there is a need to find new tools for promoting retail businesses. The article determines that the modern promotion measures considered by scientists are unsystematic, there is no approach to the choice of promotion tools by retail enterprises of different types.
It has been researched that the most promising are the directions of trading by such innovative methods: neuromarketing, innovative activity, event-events and introduction of social marketing. The approach to choosing effective ways of competitiveness depending on the type of retail networks is formed. Yes, audio marketing has advantages and ease of use when compared to aromarketing. The most relevant innovative tools that can be applied to all types of networks are the availability of Wi-Fi and electronic price tags, at the expense of relatively low cost and constant effect. Neuromarketing is effective only under continuous use. Innovative activity at the enterprise is introduced gradually due to high costs. The proposed activities are permanent, so the amount of costs is further reduced and customer comfort increases. Event activities have many tools and have a greater impact on customer mood and loyalty. However, a large number of event events can adversely affect the image of the retail network.
Keywords: promotion, innovative methods, retail, efficiency, neuromarketing, innovative technologies, event events, social marketing.
RATIONALE OF DIRECTIONS OF STATE REGULATION OF SOCIAL SECTOR OF NATIONAL ECONOMY
Authors: Hubarieva I.
Published: February 2020

It is proposed to substantiate the directions of state regulation of the social sector of the national economy using a methodological approach to assess the level of development of the social sector of the national economy, which provides on the basis of an integrated assessment (which combines the national and regional level, includes the following components: income / expenditure, demography, macroeconomics employment) to determine the level of development of the social sector of the national economy with the subsequent identification of the problem field by specific composition ymi. The sequence of assessment of the level of development of the social sector of the national economy includes the following stages: formation of components and systems of indicators for assessing the level of development of the social sector of the national economy; an integrated assessment of the level of social sector development at regional and national levels; identification of the problematic field of state regulation of the social sector of the country.
Keywords: state regulation, social sector, national economy, integral indicator.
Diagnostics of the location of damage to tubing oil well pipes
Authors: Ishmuratov Timur A. , Sultanov Rif G. , Khusnutdinova Milyausha N.
Published: February 2020

The study is devoted to the mathematical description of the process of oil outflow in places of leakage of the tubing string, which allows a computer to locate a leakage in the tubing.
The authors propose methodology for identifying defects in the tubing and determining the location of the leak. The uniqueness of this methodology lies in quick determination of the place of leakage without the use of specialists, sophisticated and specialized equipment.
Mathematical modeling of oil flow in the tubing requires the apparatus of continuum mechanics. It is a general belief that the movement of oil in the pipe flows at low speeds due to its outflow from the hole. Using the general equations of mass and energy balance, the authors have obtained differential equations of fluid motion in a vertical pipe in the process of its outflow from the tubing and in the process of injection. Analytical expressions are the solution to these equations, as they can help in estimating the degree of damage and its location, as well as the feasibility of its eliminating.
The results show that an increase in the leakage and injection times leads to improving accuracy of locating damage. Thus, when conducting various geological and technical measures (GTM) at the well, it is possible to assess the presence of leakage and its intensity when deciding on the repair of tubing.
Data Tagging in Medical Images: A Survey of the State-of-Art
Authors: Chaki Jyotismita , Dey Nilanjan
Published: February 2020

A huge amount of medical data is generated every second, and a significant percentage
of the data are images that need to be analyzed and processed. One of the key challenges in this regard
is the recovery of the data of medical images. The medical image recovery procedure should
be done automatically by the computers that are the method of identifying object concepts and assigning
homologous tags to them. To discover the hidden concepts in the medical images, the lowlevel
characteristics should be used to achieve high-level concepts and that is a challenging task. In
any specific case, it requires human involvement to determine the significance of the image. To allow
machine-based reasoning on the medical evidence collected, the data must be accompanied by
additional interpretive semantics; a change from a pure data-intensive methodology to a model of
evidence rich in semantics. In this state-of-art, data tagging methods related to medical images are
surveyed which is an important aspect for the recognition of a huge number of medical images. Different
types of tags related to the medical image, prerequisites of medical data tagging, different
techniques to develop medical image tags, different medical image tagging algorithms and different
tools that are used to create the tags are discussed in this paper. The aim of this state-of-art paper
is to produce a summary and a set of guidelines for using the tags for the identification of medical
images and to identify the challenges and future research directions of tagging medical images.
Prevention and Healing of Calcium Signaling Mediated Neuronal Damage on successive Administration of Flavonoid Enriched Pterocarpus Marsupium Roxb in Peripheral Neuropathy Model
Authors: Shaju Neethi , Gautam Mrinmoy , Khayum Abdul , Venkatesh Gunasekaran
Published: February 2020

Background:

Modern research on peripheral neuropathy circumstance utter that treatments
with Vincristine (VCR) disturb the microtubular cells in sensory and motor neurons due to calcium
over- load in sciatic nerve, unfortunately, VCR triggering the release of Tumor necrosis factor-α
(TNFα) in central neurons causes excitotoxicity as well. Although ethnomedical information specifies
that Pterocarpus marsupium Roxb (PM) is widely used for various nervous disorders, not yet justified
on VCR induced peripheral neuropathy and in relation to central mechanism.

Objective:

This study is aimed to explore the possible central and peripheral mechanism of flavonoid
enriched PM in VCR induced neuropathy model.

Methods:

Neuropathic pain was induced in female Wistar rats by VCR (75μg/ kg/day, i.p) for 10 days.
Nociceptive thresholds were assessed by subjecting them to behavioral and biochemical estimation, proinflammatory
cytokines along with morphological evaluation.

Results:

PM significantly increased the nociceptive threshold evident from various behavioral models in
comparison to VCR group. More importantly, PM significantly reversed the VCR induced calcium elevation,
glutamate and aspartate release in the brain.

Discussion:

It was also observed that the raised TNF-α, Interleukin-1β were controlled and interleukin-
10 was elevated in sciatic nerve after PM treatment. Evident from histology, PM markedly reversed the
VCR induced axonal degeneration, Schwann cell hyperplasia, and myelin fibrosis.

Conclusion:

Flavonoid enriched PM both 100 & 200mg/kg post and co-administration exerted a preventive
and curative effect in VCR induced neuropathic pain by controlling calcium-mediated excitotoxicity
through peripheral and central mechanism.
Nanocrystalline ZnO: A Competent and Reusable Catalyst for the Preparation of Pharmacology Relevant Heterocycles in the Aqueous Medium
Authors: Saha Moumita , Das Asish R.
Published: February 2020

:

Nanoparticle catalyzed synthesis is a green and convenient method to achieve most of the chemical transformations in water or other green solvents. Nanoparticle ensures an easy isolation process of catalyst as well as products from the reaction mixture avoiding the hectic work up procedure. Zinc oxide is a biocompatible, environmentally benign and economically viable nanocatalyst with effectivity comparable to the other metal nanocatalyst employed in several reaction strategies. This review mainly focuses on the recent applications of zinc oxide in the synthesis of biologically important heterocyclic molecules under sustainable reaction conditions.

:

Application of zinc oxide in organic synthesis: Considering the achievable advantages of this nanocatalyst, presently several research groups are paying attention in anchoring zincoxide or its modified structure in several types of organic conversions e.g. multicomponent reactions, ligand-free coupling reactions, cycloaddition reaction, etc. The advantages and limitations of this nanocatalyst are also demonstrated. The present study aims to highlight the recent multifaceted applications of ZnO towards the synthesis of diverse heterocyclic motifs. Being a promising biocompatible nanoparticle, this catalyst has an important contribution in the fields of synthetic chemistry and medicinal chemistry.
Comparison of Regulatory Requirements for Pharmaceuticals in Non- European Union Member States Kosovo, Ukraine and Serbia
Authors: Jani Shivani , Patel Nilesh , Chotaliya Urvi , Patel Ashok
Published: February 2020

Background:

Literature review suggested that regulatory guidelines should be harmonized
for better processing of applications and for the upliftment of the regulatory field. Therefore
it was thought worthwhile to compare the guidelines for countries where there is requirement of
harmonization. Kosovo, Ukraine and Serbia were selected because of being European countries
and still they are not a part of EU.

Introduction:

Kosovo, Ukraine and Serbia are small countries of Europe but they are not members
of European Union. They have their own guidelines for the submission of MAA for marketing
of pharmaceuticals and medical devices. They are trying to obtain the EU membership and
therefore it was worthwhile to compare the guidelines of these countries.

Method:

The registration process of pharmaceuticals in Kosovo, Ukraine and Serbia was studied
throughly. Along with it, the guidelines for European Union were also studied. A comparison of
guidelines of all the three countries with the guidelines of European Union for pharmaceuticals
was carried out.

Result:

The comparison of guidelines showed that there are still some changes needed in the
guidelines of Kosovo, Ukraine and Serbia before they can merge with the guidelines of European
Union. Some of the points in the guidelines are very different from the guidelines of EU.

Conclusion:

So it was worthwile to study the regulatory requirements of pharmaceuticals in Non-
European Union Member States Kosovo, Ukraine and Serbia.
THE DEVELOPMENT OF ROLE-PLAYING LEARNING MODEL DESIGN ON ACCOUNTING SUBJECT
Authors: Saptono Laurentius , Brataningrum Natalina Premastuti
Published: February 2020

THE DEVELOPMENT OF ROLE-PLAYING LEARNING MODEL DESIGN ON ACCOUNTING SUBJECTAbstractThis study was aimed to generate a product of an effective role-playing learning model design on basic competences of practicing accounting cycles in service companies for the eleventh grade students. The research procedures were done based on ADDIE model. The developed product design was validated by the experts of learning materials, the experts of learning media, the experts of learning design, and the experts of characters building. The product was tested on Stella Duce 1 Senior High School students both in small groups which consisted of 12 people and a large group of 40 people. The instruments which was used to assess product validity included material aspects, media aspects, aspects of learning, and aspects of character building. The result of the experts’ validation and testing to students showed that it was a very good developed product. This meant that the role-playing learning model design on basic competences of practicing accounting cycles in service companies for the eleventh grade students was worth implementing in the learning activities.PENGEMBANGAN DESAIN PEMBELAJARAN MODEL ROLE-PLAYING PADA MATA PELAJARAN AKUNTANSIAbstrakPenelitian ini bertujuan untuk menghasilkan produk berupa desain pembelajaran model role-playing yang efektif untuk pembelajaran pada kompetensi dasar mempraktikkan siklus akuntansi perusahaan jasa untuk siswa kelas XI SMA. Prosedur pengembangan produk penelitian dilakukan berdasarkan Model ADDIE. Produk yang dikembangkan divalidasi oleh ahli materi pembelajaran, ahli media pembelajaran, ahli desain pembelajaran, dan ahli pendidikan karakter. Produk diujicobakan kepada siswa-siswa SMA Stella Duce 1 baik kelompok kecil yang terdiri dari 12 orang maupun kelompok besar yang terdiri dari 40 orang. Instrumen untuk menilai validitas produk mencakup aspek materi, aspek media, aspek pembelajaran, dan aspek pendidikan karakter. Hasil validasi dari para ahli dan hasil ujicoba pada siswa-siswa menunjukkan bahwa produk yang dikembangkan dinyatakan sangat baik. Artinya, desain model role-playing yang dikembangkan untuk pembelajaran pada kompetensi dasar mempraktikkan siklus akuntansi perusahaan jasa untuk siswa kelas XI SMA layak untuk diimplementasikan dalam praktik pembelajaran.
DEVELOPING INTERACTIVE MULTIMEDIA LEARNING FOR PSYCHOMOTOR DOMAIN TO STUDENTS OF VOCATIONAL HIGH SCHOOL
Authors: Nugraha Chandra Adhitama , Wahyono Sugeng Bayu
Published: February 2020

PENGEMBANGAN MULTIMEDIA PEMBELAJARAN INTERAKTIF UNTUK RANAH PSIKOMOTORIK SISWA SEKOLAH MENENGAH KEJURUANAbstrakPenelitian ini bertujuan untuk menghasilkan multimedia yang layak dan memiliki kontribusi dalam proses pembelajaran dengan memperhatikan ranah psikomotorik. Subjek penelitian adalah siswa kelas XI Sekolah Menengah Kejuruan. Penelitian ini menggunakan metode peneltian Research and Development yang diadaptasi dari Borg and Gall. Strategi pembelajaran menggunakan model ASSURE. Penelitian ini menempuh proses validasi masing-masing dua ahli materi dan ahli media. Validasi ahli bertujuan untuk menilai tingkat kelayakan dari multimedia. Penelitian ini menggunakan analisis deskriptif kuantitatif. Pengumpulan data menggunakan pedoman wawancara, lembar observasi, angket kelayakan multimedia oleh ahli media, angket kelayakan multimedia oleh ahli materi dan angket kelayakan multimedia oleh siswa. Skala penilaian menggunakan skala Likert dengan skala 1-5. Hasil dari penelitian menunjukan bahwa produk multimedia pembelajaran yang dikembangkan layak digunakan dan memiliki kontribusi pada ranah psikomotorik siswa. Hasil dari validasi ahli dan uji coba produk diperoleh hasil dengan rentang skor minimal memiliki kriteria “baik”, sehingga dikatakan produk yang dikembangkan “layak”.AbstractThis study aims to produce a viable multimedia that contributes in the learning process by paying attention to the psychomotor domain. The subject of research students of Grade XI Vocational High School. This research and development referred to the nine steps of Borg and Gall’s development model. This learning strategies using ASSURE model. This product was validated by two material experts and two media experts. Validating the material aimed to know the feasibility level of the multimedia. This research uses quantitative descriptive analysis. The data were collected by using interview guidelines, observations sheet, and a multimedia feasibility questionnaire by a media expert, a multimedia feasibility questionnaire by a material expert and a multimedia feasibility questionnaire by students. Scale assessment using Likert scale with scale 1-5. The result of this research showed that the multimedia learning is feasible to use and contribute in student psychomotor field. The results of experts validation and product trial results obtained with a minimum score range having a "good" criterion, so that said the developed product is "feasible".Keywords: multimedia, psychomotor, Research and Development
ANALISIS OPEN GOVERNMENT PADA DIREKTORAT JENDEREAL ENERGI BARU, TERBARUKAN DAN KONSERVASI ENERGI, KEMENTERIAN ENERGI DAN SUMBER DAYA MINERAL REPUBLIK INDONESIA
Authors: Respitawulan Anggraeni
Published: February 2020

The change paradign in energy demand side and supply side management make goverment should think creatively to increase nergy national mix 23% at 2025 with new and renewable energy development programme. This research aims to describe the open goverment strategy condition in new and renewable energy development programme use kualitatif method through interview and observation. In general pelaksaan open government have on the directorate general ebtke has been implemented in terms of planning, implementation and supervision activities. This reseach find that new and renewable energy programme basically has a good platform, proven from a lot of using information and technology to support the programme.  But unfortunately many platform are not used optimally to increase tranparency, participation and collaboration as a open goverment theory to the new and renenwable energy programme. In the transparency aspect informatio technology has used to broadcast information, in participation aspect, public has no access to policy formulation. While in the collaboration aspect show with many cooperation between goverment, private sector, public, NGO and other institution or country in various new and renewable energy programme.
PENANGGULANGAN ANAK JALANAN BERBASIS COMMUNITY DEVELOPMENT DI KOTA SERANG
Authors: Hasanah Budi , Putri Liza Diniarizky
Published: February 2020

Children must receive good education, positive parenting, protection and other rights so that they can growth properly. But actually, it did not happen in Kota Serang. It was caused by the increasing number of street children. There were increasing number of street children in 2016, 31 children so until now the total was 181 children. This research was about the prevention of street children based on community development with conflict theme and intervention model. This research used biddle theory with three indicators: explanatory, organizational and discussional.  This research used qualitative with descriptive method. The data from interview and deep discussion as well as observation used interactive model analysis. The results showed that there were some factors behind the number of street children in Kota Serang. Based on the FGD results, an alternative solution was need to reactivation the existing halfway house and form special team to take care the childreen who live there. Thus, the prevention of street childreen based on community development program could be run effectively.
IMPLEMENTASI KEBIJAKAN PNPK TATA LAKSANA THALASSEMIA DI KABUPATEN SUBANG
Authors: Dewanti Wanti , Irawati Ira , Halimah Mas
Published: February 2020

The increase of patients suffering Thalassemia especially in Subang district pushed the estabilishment of the organization named POPTI. The objective of this study is to analyse the role of POPTI in implementing handling policy PNPK of Thalassemia patients. The research method used is qualitative with conducting semi structured interview, observation, and documentation research. The result of this research shows that the role of POPTI is significant important in handling Thalassemia patients, yet the role has not fully gone well. There is still lack of coordination and communication between members and related agencies. This is the reason for implementing the handling policy of Thalassemia patients in Subang district, which hasn’t been optimal. Therefore, it is necessary to improve the system and awareness of chairman and members to coordinate and collaborate for handling Thalassemia patients in Subang district.
ANALISIS PERAN STAKEHOLDERS DALAM PENGATURAN DAN PEMBINAAN PEDAGANG KAKI LIMA
Authors: Susilo David Adi , Astuti Retno Sunu , Priyadi Budi Puspo
Published: February 2020

This study aims to determine the role of stakeholders in the regulation and guidance of street vendors in Tlogosari Kulon Village, Pedurungan District, Semarang City and to identify inhibiting factors in the implementation and management of street vendors. This research method uses descriptive qualitative, by collecting observational data, interviews, library research and documentation, interview techniques conducted to several informants including the Semarang City Trade Office, Semarang City Police Satpol, Tlogosari Kulon Urban Village, Street Vendors (PKL) in the Kelurahan Tlogosari Kulon and the Tlogosari Kulon Community. The results showed that the role of the Semarang City Trade Office as a policy creator, coordinating with other agencies and PKL Tlogosari Kulon, as well as building PKL Shelter Suryokusumo Market. The role of the community as an implementator is to provide active input in the regulation or preparation of public policies in the regulation and guidance of street vendors, both directly and indirectly. While the inhibiting factors are lack of effective communication, lack of human resources and a fragmented bureaucratic structure.
MULTIPLICATION EXAMINATION OF TURMERIC EXPLANTS USING AUXIN AND CYTOKININ TO MODIFIED MEDIA
Authors: Azizah Romadhoni Nur , Suminar Erni , Nuraini Anne , Mubarok Syariful
Published: February 2020

This study was aimed at obtaining the type and concentration of cytokines as well as the optimal concentration of auxin for the multiplication of turmeric shoots in vitro. The trial was conducted in September 2017 until February 2018 at the Tissue Culture Seed Technology Laboratory of the Faculty of Agriculture, Padjadjaran University. The materials used in this study were Murashige and skoog modified multiplication medium, jelly, sterile distilled water, HgCl2, 70% alcohol, clorox, tween 80 and fungicide and bactericidal. Growth Regulating Substances (GRS) used are BAP, TDZ, Zeatin and NAA. The explant source used was derived from the shoot of turmeric clones from Bogor. The experimental design in this study was Completely Randomized Design (CRD) with seven treatments and four replications. The planting medium used was Murashige Skoog Modification (MS) with the addition of Benzyl Amino Purine (BAP) 9 mg L-1, Thidiazuron (TDZ) 1 mg L-1, Zeatin 0.1 mg L-1 and NAA (0.01 mg L-1, 1 mg L-1). The results show that the combination of BAP 9 mg L-1 and NAA 0.01 mg L-1 produced the highest shoot induction at 12 weeks after planting. Giving zeatin 0.1 mg L-1 and NAA 1 mg L-1 produces the highest shoot length at 12 weeks after planting.PENGUJIAN MULTIPLIKASI EKSPLAN KUNYIT DENGAN PENAMBAHAN AUKSIN DAN SITOKININ PADA MODIFIKASI MEDIAPenelitian ini bertujuan untuk mendapatkan jenis dan konsentrasi sitokinin serta konsentrasi auksin yang optimal untuk multiplikasi tunas kunyit secara in vitro. Percobaan dilaksanakan pada bulan September 2017 sampai Februari 2018 di laboratorium Kultur Jaringan Teknologi Benih Fakultas Pertanian Universitas Padjadjaran. Bahan yang digunakan dalam penelitian ini adalah murashige dan skoog modified multiplication medium, agar-agar, aquades steril, HgCl2, alkohol 70%, clorox, tween 80, fungisida, dan bakterisida. Zat Pengatur Tumbuh (ZPT) yang digunakan yaitu BAP, TDZ, Zeatin, dan NAA. Sumber eksplan yang digunakan yaitu berasal dari tunas kunyit klon asal Bogor. Rancangan percobaan pada penelitian ini yaitu Rancangan Acak Lengkap (RAL) dengan tujuh perlakuan dan empat ulangan. Media tanam yang digunakan yaitu Murashige Skoog Modifikasi (MS) dengan penambahan Benzyl Amino Purine (BAP) 9 mg L-1, Thidiazuron (TDZ) 1 mg L-1, Zeatin 0,1 mg L-1, dan NAA (0,01 mg L-1, 1 mg L-1). Hasil percobaan menunjukkan bahwa kombinasi BAP 9 mg L-1 dan NAA 0,01 mg L-1 menghasilkan induksi tunas tertinggi pada 12 MST. Pemberian zeatin 0,1 mg L-1 dan NAA 1 mg L-1 menghasilkan panjang tunas tertinggi pada 12 MST.
THE ROLE OF HYDROGEL AND INCUBATION TIME TOWADS PH, C-ORGANIK, AND N-TOTAL SOIL
Authors: Winingsih Atih , Suriadikusumah Abraham , Mulyani Oviyanti , Nurbaity Anne , Trinuranisofyan Emma
Published: February 2020

The study was aimed at determining the role of hydrogels and the incubation time on pH, organic C and N-total soil with indicators of sweet corn plants (Zea mays Saccharata Sturt) on Jatinangor inceptisols. The study was conducted from February 2018 to April 2018 at the Ciparanje Experimental Field, Faculty of Agriculture, Padjadjaran University. The study used a Randomized Block Design (RBD) with nine treatments and three replications, consisting of controls; mixed hydrogels and urea incubation and urea only incubation . The parameters observed were pH using the Potentiometric method, C-Organic using the Walkey and Black and N-Total using the Kjeldahl method. The data then were analyzed by variance. Significant testing was conducted to determine the effect of treatment using the Fisher Test at the level of 5%. The results show that there is an effect of hydrogels and the incubation time of hydrogels on pH, organic C and N-total soil. The control treatment shows the highest pH of 6.88. The urea treatment and incubation hydrogel of 20 days shows the highest organic C at 2.80% and the highest N-total is found in the treatment of urea and 40 day incubation hydrogel which is 0.34%.PERAN HIDROGEL DAN WAKTU INKUBASINYA TERHADAP pH, C-ORGANIK, DAN N-TOTAL TANAHPenelitian bertujuan untuk mengetahui peran hidrogel dan waktu inkubasinya terhadap pH, C-organik dan N-total tanah dengan indikator tanaman jagung manis (Zea mays Saccharata Sturt) pada inceptisols Jatinangor. Penelitian dilakukan mulai bulan Februari 2018 hingga April 2018 di Lahan Percobaan Ciparanje Fakultas Pertanian Universitas Padjadjaran. Penelitian menggunakan Rancangan Acak Kelompok (RAK) dengan sembilan perlakuan dan tiga kali ulangan, yang terdiri atas kontrol; hidrogel dan urea inkubasi serta urea inkubasi. Parameter yang diamati adalah pH dengan menggunakan metode Potensiometri, C-Organik dengan menggunakan metode Walkey and Black dan N-Total dengan menggunakan metode Kjeldahl. Data hasil pengamatan pada penelitian akan dianalisis dengan sidik ragam. Pengujian signifikan untuk mengetahui pengaruh perlakuan digunakan Uji Fisher pada taraf 5%. Hasil penelitian menunjukkan terdapat pengaruh hidrogel dan waktu inkubasi hidrogel terhadap pH, C-organik dan N-total tanah. Perlakuan kontrol menunjukkan pH tertinggi yaitu 6,88. Perlakuan urea dan hidrogel inkubasi 20 hari menunjukkan C-organik tertinggi yaitu 2,80% dan N-total tertinggi yaitu perlakuan urea dan hidrogel inkubasi 40 hari yaitu 0,34%.
Разогрев электронов в чистом Ge в квантовом магнитном поле при термическом возбуждении носителей заряда
Authors: Банная В.Ф. , Никитина Е.В.
Published: February 2020

The results of an experimental study on charge carriers heating by an electric field (E) in pure Ge in a quantum magnetic field (H) at (E⊥H) at low temperatures (T=4,2;1,8 K) under thermal excitation are considered. It is shown that the dependence of E and H thermal ionization coefficient affects the average carrier lifetime under these conditions.
The obtained results are in qualitative agreement with the theory of cascade capture of carriers on isolated centers in crossed electric and magnetic fields.
Фотолюминесцентные и фотоэлектрические свойства тонкопленочной структуры ZnO-LiNbO-=SUB=-3-=/SUB=- в ультрафиолетовом и видимом диапазонах спектра
Authors: Григорьев Л.В. , Морозов И.С. , Журавлев Н.В. , Семенов А.А. , Никитин А.А.
Published: February 2020

In article are presebted the results of study the structural, optical, photoluminescent and photoelectric properties structure of the layer thin-film ZnO on the monocrystal LiNbO3 substrate. Presents the results of X-ray structural analysis of a zinc oxide thin film synthesized on a single-crystal lithium niobate substrate and on a KU-1 quartz substrate are presented. Are presented the results investigations of transmission spectra, reflection spectra and absorption spectra in the ultraviolet and visible spectral range. Are presented investigations spectral dependence of photoluminescence and the spectral dependence of the photoconductivity currents in the thin film structure of ZnO-LiNbO3 and the structure of ZnO-SiO2 in the ultraviolet and visible spectral range.
Механизмы перехода от ритмической активности к пачечной в модели ноцицептивного нейрона
Authors: Дик О.Е.
Published: February 2020

The transitions from tonic spiking to bursting for the nociceptive neuron model have been studied with changing the external stimulus value. The presence of the fold limit cycle bifurcation in the structure of the bifurcation diagram of the fast subsystem and the torus bifurcation in the structure of the bifurcation diagram of the full system lead to the emergence of special solutions of the type torus canards in these transitions. This confirms the assumption that torus canards are an obligatory feature for transitions between rhythmic and burst discharges
Фотокаталитические свойства композиции alpha-Bi-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=-/Bi в видимой области света в зависимости от концентрации металлического висмута и степени дефектности кристаллической решетки оксида висмута
Authors: Кириченко Е.А. , Каминский О.И. , Зайцев А.В. , Макаревич К.С. , Пячин С.А.
Published: February 2020

The photocatalytic activity of the α-Bi2O3/Bi heterostructure compositions obtained by the method of low-temperature pyrolysis of bismuth-sorbitol complexes was investigated. The effectiveness of catalysts is estimated by the rate of decomposition of methylene blue (MS) upon irradiation with light of the visible spectrum. The catalysts obtained by varying the amount of sorbitol in the composition of the precursor organo-mineral complex of bismuth and by varying the temperature of synthesis, differ in different contents of metallic Bi and have different degrees of defectiveness of the α-Bi2O3 crystal lattice. It is established that isothermal annealing of α Bi2O3/Bi compositions in air in the range of 400–600°C leads to relaxation of defects and an increase in the volume of the α-Bi2O3 crystal lattice. An increase in the annealing temperature to 550°С is accompanied by an increase in the catalytic activity of α-Bi2O3/Bi. However, at higher temperatures, degradation of the heterostructure occurs as a result of the oxidation of metallic bismuth, and the catalytic activity of the composition decreases.
Использование пленок из многослойного графена в качестве покрытий светоизлучающих GaAs-структур
Authors: Алафердов А.В. , Вихрова О.В. , Данилов Ю.А. , Звонков Б.Н. , Мошкалев С.А.
Published: February 2020

Экспериментально обнаружено существенное (почти на два порядка величины) увеличение интенсивности фото- и электролюминесценции диодной структуры с квантовой ямой InGaAs/GaAsSb/GaAs, слоем GaMnAs в качестве спинового инжектора и контактным покрытием из пленки многослойного графена. Результат объясняется возможным образованием гибридной системы многослойного графена и полупроводника GaAs под воздействием излучения He-Ne-лазера, приводящим к изменению зонной диаграммы гетероструктуры. Ключевые слова: светоизлучающая структура, GaAs, квантовая яма, многослойный графен, люминесценция, лазерное воздействие.
Толстые эпитаксиальные слои alpha-Ga-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=- : Sn на профилированной сапфировой подложке
Authors: Николаев В.И. , Печников А.И. , Гузилова Л.И. , Чикиряка А.В. , Щеглов М.П. , Николаев В.В. , Степанов С.И. , Васильев А.А. , Щемеров И.В. , Поляков А.Я.
Published: February 2020

Abstract Epitaxial layers of a new wide-band semiconductor (α-Ga_2O_3 doped with tin) have been grown by chloride epitaxy on smooth and patterned substrates, which are widely used to increase the emission yield in high-efficiency LED structures based on InGaN, and studied. The properties of the obtained gallium-oxide layers have been compared. Both types of samples had n -type conductivity, but the frequency and voltage dependences of their capacitance differed. Differences in the dislocation structure of epitaxial α-Ga_2O_3 layers on smooth and patterned substrates have been identified by X-ray diffractometry.
Изучение влияния допирования калием на характеристики перовскитного солнечного элемента
Authors: Вильданова М.Ф. , Никольская А.Б. , Козлов С.С. , Карягина О.К. , Шевалеевский О.И.
Published: February 2020

We have fabricated a series of potassium-doped (K-doped) perovskite solar cells (PSCs). Structural investigations of the developed PSCs have shown that alkai doping affects the perovskite layer structure and morphology with the increase of the crystallite size and surface uniformity. K-doped samples exhibite higher PV performance and improved operational stability compared to the control series of undoped PSCs, due to retarded recombination processes.