bluuebunny/crossref_metadata_2025 huggingface dataset:
PCD-otofajinin bitki immünitesiyle korelasyonu
Authors: BAŞ Berna
Published: March 2023

Önemli bir katabolik olay olan otofaji bitkilerin gelişim süreçlerinde ve biyotik/abiyotik strese verdiği tepki sonucunda istenmeyen/hasarlı yapıların/moleküllerin sitoplazmik içerikle beraber vakuollerin içine alınarak litik enzimlerle parçalanması ve nihayet sitoplazmanın tasfiyesiyle hücre ölümü olayıdır. Otofaji konukçu-patojen interaksiyonlarında bitki immünitesinin düzenlenmesinde birçok önemli role sahiptir. Patojen organizmaların yaşam stratejilerine göre bitkilerde otofaji yoluyla hipersensitif reaksiyon (HR) ölümleri ya baskılanmakta ya da teşvik edilmektedir. Aslında otofaji bitki hücrelerinin biyotik faktörlere karşı kendini korumak ve homeostazı stabil tutmak amacıyla patojenleri veya patojene ait yapıları ortadan kaldırmak suretiyle yeni bir adaptasyon yolu olarak da düşünülebilir. HR hücre ölümlerinde otofajinin moleküler mekanizması kesin olarak bilinmese de, otofajiye dahil olan proteolitik enzimlerin HR hücre ölümlerini desteklemesi nedeniyle, bitki ETI (Effector-Triggered Immunity) immün sistemin bileşenlerinden olan HR programlı hücre ölüm kapsamında ele alınmaktadır. Otofaji bitki immünitesinde anti-patojenik yeni bir sistem olmaya aday doğal bir hücresel prosestir. Yeni çalışmalar, bitki immünitesinde HR-PCD (HR-Programmed Cell Death) sürecinde hücre yıkımının otofajiyle bağlantılı olduğunu düşündürmektedir. Bu derleme otofajik sistem ağının bitki immünitesiyle koreleli olduğunu örneklerle açıklamaktadır.
Efficacy of school-based career guidance interventions: A review of recent research
Authors: Sharapova Nargiza , Zholdasbekova Saule , Arzymbetova Sholpan , Zaimoglu Omer , Bozshatayeva Gulshat
Published: March 2023

This paper aims to examine the impacts of career guidance interventions on school students’ career-related skills, knowledge and beliefs by combining relevant empirical studies conducted in the last 10 years. A random-effects meta-analytic technique was employed for this purpose. After screening, electronic databases using pre-defined eligibility criteria, nine studies involving a total of 1,433 participants were included in the final meta-analysis. The analysis yielded a weighted mean effect size of 0.42 (95% confidence interval = 0.19, 0.65; z = 3.61, p < 0.01) which may be construed as a moderate-to-high effect size with a significant difference between the treatment and control conditions at post-treatment. As a result, post-test career-related outcomes in students who received career guidance were significantly higher than in non-guidance groups. The results suggest that career interventions may provide some modest developmental progression in school-age children and adolescents particularly through improving learners’ career decidedness and attitudes such as future time perspective. These findings might have strategic implications for policy and practice. This paper extends past research on career guidance effectiveness by identifying the combined effect size of relevant career interventions.
Lokasyon Bazlı Reklamların Tüketici Tutumları ve Satınalma Niyetleri Üzerindeki Etkilerinin İncelenmesi (Examining the Effects of Location-Based Advertising on Consumer Attitudes and Purchasing Intentions)
Authors: Tekin Burcu , Baş Mehmet
Published: March 2023

Amaç –Bu çalışmanın amacı, lokasyon bazlı reklamların tüketici tutumları ve satın alma niyetleri üzerindeki etkilerini incelemektir.Dolayısıyla, çalışmada Bruner ve Kumar (2007)’ın lokasyon bazlı reklamlara yönelik geliştirdikleri tutum ölçeği baz alınmaktadır.Bruner ve Kumar (2007) tarafından lokasyon bazlı reklamlara yönelik geliştirilen tutum ölçeği bu çalışmada yeniden incelenmiştir.Yöntem –Çalışmanın ana kitlesi Türkiye'de akıllı telefon kullanan tüketicilerden oluşmaktadır.Çalışmada kolayda örnekleme yöntemi kullanılmıştır.Veriler elektronik ortamda anket yoluyla toplanmıştır ve IBM SPSS 20 programı kullanılarak analiz edilmiştir.Bulgular –Araştırma bulgularına göre, teknoloji düşkünlüğünün lokasyon bazlı reklamlara yönelik tutum üzerinde anlamlı bir etkiye sahip olduğu belirlenmiştir. Buna karşılık analiz sonuçları teknoloji fikir liderliği, materyalizm ve kötümserliğin lokasyon bazlı reklamlara yönelik tutum üzerinde etkisi olmadığını ortaya koymuştur. Buna ek olarak lokasyon bazlı reklamlara yönelik tutumların satın alma niyetini olumlu yönde etkilediği ve cinsiyet üzerinde farklılık göstermediği belirlenmiştir.Tartışma –Araştırma sonucu Bruner ve Kumar (2007)’ın lokasyon bazlı reklamlara yönelik geliştirdikleri modelin boyutlarından farklılaşmış ve yalnızca teknoloji düşkünlüğünün modele katkı sağladığı tespit edilmiştir. Lokasyon bazlı reklamları, diğer reklam türlerinden ayrıştırmalı ve lokasyon bazlı reklamlara yönelik tutumları belirleyen daha farklı değişkenler üzerine yoğunlaşılması gerektiği söylenebilmektedir.
Pay Geri Alım Duyurularının Pay Getirileri Üzerindeki Etkisi: Borsa İstanbul da Covid-19 Salgını Öncesindeve Sırasında Karşılaştırmalı Bir Analiz (The Impact of Share Repurchase Announcements on Share Returns: AComparative Analysis Before and during Covid-19 Pandemic in Borsa Istanbul)
Authors: Kaya Bekir , Öner Kaya Emine
Published: March 2023

Amaç – Bu çalışmanın amacı, Borsa İstanbul’da işlem gören şirketlerin pay geri alım duyurularının pay getirileri üzerindeki kısa dönem etkisinin belirlenmesidir. Ayrıca, Covid-19 salgını öncesinde ve sırasında pay fiyatlarının pay geri alım duyurularına verdiği tepki incelenmekte ve karşılaştırılmaktadır. Yöntem – Çalışmanın örneklemi, 2018-2022 döneminde Kamuyu Aydınlatma Platformu (KAP)’nda 72 şirket tarafından açıklanan pay geri alım işlemlerinin başlatılmasına ilişkin 101 bildirimi içermektedir. Olay çalışması yöntemi kullanılarak, belirlenen farklı olay pencereleri için günlük ortalama anormal getiriler (AAR) ve kümülatif ortalama anormal getiriler (CAAR) hesaplanmış ve ardından bu getirilerin anlamlılığını test etmek için parametrik ve parametrik olmayan testler uygulanmıştır. Bulgular – Test sonuçları, pay geri alım duyurularının pay getirileri üzerinde istatistiksel olarak anlamlı pozitif etkilere sahip olduğunu göstermektedir. Ayrıca pay fiyatlarının pay geri alımı duyurularına verdiği tepkide, 11 Mart 2020 tarihinde Covid-19’un pandemi ilan edilmesinden önce ve sonra istatistiksel olarak anlamlı bir farklılık olduğu tespit edilmiştir. Tartışma – Bulgular, Borsa İstanbul’da pay geri alım duyurularının ardından anormal getiri elde etme imkânı olduğunu göstermektedir. Ayrıca elde edilen sonuçların, düşük değerlenme ve sinyal verme hipotezlerini desteklediğini ifade etmek mümkündür.
Tüketici Tercih ve Davranışlarında İyi Tarım Uygulamalarına Yönelik Bir Araştırma: Karaman İli Örneği (A Study on Good Agricultural Practices in Consumer Preferences and Behaviors: The Case of Karaman Province)
Authors: Oflaz Özkan , Göktaş Bora , Erdoğan Tarakçı İnci
Published: March 2023

Amaç –Organik Tarım ürünlerinin birim maliyetinin yüksek olması, konvansiyonel ürünlerin ise, kimyasal kalıntılar barındırması nedeniyle insan sağlığına, çevreye (toprak, su vb.) ve doğadaki diğer yaşam paydaşlarına (hayvanlar, bitkiler vb.) zararlı olması tüketicileri iyi tarım uygulamaları ürünlerine yöneltmiştir. İyi Tarım Uygulamalarına (İTU) yönelik tüketici tutumlarını “İnsan Sağlığı”, “Çevreye Faydası” ve “Satın Alma” boyutu bakımındanincelemek ve istatistiksel sınamalar yaparak bulguları ortaya koymaktır. Yöntem –Araştırmanın popülasyonu, Karaman ilinde gıda ürünleri alışverişleri yapan hane halkları arasından, kolayda örnekleme yöntemi ile seçilmiştir. Nicel araştırma modeli benimsenerek yürütülen bu çalışmada veri toplama aracı olarak anket kullanılmıştır. Ankette demografik sorular, tüketici tutum ölçeği ve marka kişiliği ölçeğinden yararlanılmıştır. Elde edilen veriler, SPSS-25 istatistik programı kullanılarak analiz edilmiştir. Ayrıca bu veriler ile tek yönlü varyans (Anova) testi, T-testi, Korelasyon analizi yapılmıştır.Bulgular –Araştırma sonucunda ortaya çıkan bulgulara göre; İTÜ’nininsan sağlığına ve çevreye faydalıdır algısı gibi boyutların tüketicilerin tutum ve davranışlarına etki ettiği anlaşılmıştır. Ayrıca bu boyutlar arasında tüketicilerin demografik özelliklerine dair istatistiksel olarak anlamlı farklılıklar elde edilmiştir.Tartışma –Tüketicilerin sağlık ve çevre bilincine bağlı olarak tarımsal gıda ürünlerini satın alma noktasında tutum ve davranışlarının değiştiği görülmektedir. Bireylerin satın aldıkları gıdaların insan sağlığına olumsuz etkilerive çevreye verdikleri zararı hakkında bilgisi arttıkça insan sağlığına ve çevreye daha duyarlı hale geldikleri görülmüştür
Six Blind Men and an Elephant: Workaholism vs. Work-Engagement from the Big-Two Personality Perspective rather than the Big Five
Authors: Gözükara Yıldız İzlem , Buruk Pelin , Şimşek Ömer Faruk
Published: March 2023

Purpose – This study attempts to compare and contrast workaholism and work engagement in terms of their dispositional antecedents. Although both concepts are perceived as heavy work investment, workaholism is associated with negative consequences such as burnout, counterproductive behavior, work-family conflict, psychosomatic symptoms, and declining work performance. Work engagement, on the other hand, is associated with positive aspects that include superior performance, organizational commitment, organizational citizenship behavior, physical and mental health. To distinguish a workaholic from a work engaged employee, this study offers a bird’s eye view using the Big Two, the higher order traits of the Big Five.
Design/Methodology/Approach – The study is conducted on a sample of 250 full-time teachers (male: 154, female: 96; mean age:33.38 years) who were working at a higher education institution or a K-12 school in Istanbul, Turkey. The response rate was 90.9%. The convenience sampling method was used in data collection procedures. The data obtained by the survey method were analyzed using the structural equation modeling and common method variance techniques.
Finding – According to the results, stability was positively and significantly correlated with work engagement but negatively and significantly correlated with workaholism. Plasticity, on the other hand, was correlated strongly and positively with workaholism yet had no statistically significant correlation with work engagement. The negative and weak correlation between Stability and workaholism became a stronger path in the structural regression model, indicating the presence of a suppressor effect. Discussion – The results of this research reveal that if an organization prefers work engaged employees rather than workaholics, then during the selection process, the hiring decision makers should look for the trait Stability as well.
Identifying the Innovative Tension: A Meta-Analysis on Innovative Firm Behavior, Organizational Ambidexterity and Innovative Performance
Authors: Kula Mehmet Emirhan
Published: March 2023

Purpose –In terms of business activities determining which financial and human resources will use existing knowledge (exploitation) and which will make efforts to discover new knowledge (exploration) creates an innovative tension. Since the choice of innovative action leads to different expectations and different outputs, the cause and consequences of tension will also differ for each firm. Ultimately, the purpose of the study is to reveal the relation amongst innovative firm behavior, organizational ambidexterity,and innovative firm performance in the axis of innovative tension.Design/methodology/approach –In this study, meta-analysis was used to determine the effect size of innovative firm behavior on organizational ambidexterity and the effect size of organizational ambidexterity on innovative performance. To test the hypotheses determined in the research, the studies published since 2000 were reviewed and the appropriate ones were selected within the framework of certain criteria. The determined database is divided into two separate data sets (Dataset 1 consists of 19 studies, 30 effect values, 11246 samples -dataset 2 consists of 22 studies, 49 effect values, 98630 samples). The first data set was used to investigate the relation between innovative firm behavior and organizational ambidexterity and the second data set was used to test the relation amongst organizational ambidexterity and innovative firm performance.Findings –According to the effect size level obtained from the meta-analysis, it was found that innovative firm behavior has a positive and significant effect on organizational ambidexterity and organizational ambidexterity has a positive and significant effect on innovative performance.Discussion –Considering the requirements of the technology era we live in, it is necessary to take into account that innovative attitude and behavior, organizational ambidexterity, and innovative performance network have the power to determine not only the production of new products and services but also the rules of the competition game on the global basis. While the wrong choice to be made at this point will directly affect the life span of the firm, the right one will contribute to the effectiveness of a new actor at the level of macro competition.
Liver Transplantation for perihilar cholangiocarcinoma. Do we need to move forward?
Authors: Dopazo Cristina , Charco Ramón
Published: March 2023

Perihilar cholangiocarcinoma (pCCA) is a challenging disease with limited options. Surgical resection and adjuvant therapy remain the only established treatment for those with resectable disease. Since the publication of the Mayo protocol in 2000, neoadjuvant chemoradiation and liver transplantation have become the standard of care in selected patients with unresectable de novo pCCA or resectable pCCA arising under primary sclerosing cholangitis. However, its application is diverse worldwide, and the need for donor organs is one of the main limitations. Also, differences in the neoadjuvant regimen used were observed. In this review, we discuss the latest results of this approach, the recommended tools for diagnostic work-up, and advances in systemic therapy to improve patient selection and long-term survival.
Theranostic extracellular vesicles: a concise review of current imaging technologies and labeling strategies
Authors: Aafreen Safiya , Feng Jonathan , Wang Wenshen , Liu Guanshu
Published: March 2023

Extracellular vesicles (EVs), or exosomes, are naturally occurring nano- and micro-sized membrane vesicles playing an essential role in cell-to-cell communication. There is a recent increasing interest in harnessing the therapeutic potential of these natural nanoparticles to develop cell-free regenerative medicine and manufacture highly biocompatible and targeted drug and gene delivery vectors, amongst other applications. In the context of developing novel and effective EV-based therapy, imaging tools are of paramount importance as they can be used to not only elucidate the underlying mechanisms but also provide the basis for optimization and clinical translation. In this review, recent efforts and knowledge advances on EV-based therapies have been briefly introduced, followed by an outline of currently available labeling strategies by which EVs can be conjugated with various imaging agents and/or therapeutic drugs and genes. A comprehensive review of prevailing EV imaging technologies is then presented along with examples and applications, with emphasis on imaging probes and agents, corresponding labeling methods, and the pros and cons of each imaging modality. Finally, the potential of theranostic EVs as a powerful new weapon in the arsenal of regenerative medicine and nanomedicine is summarized and envisioned.
Monitoramento tecnológico do processamento do óleo de licuri (Syagrus coronata) para fins alimentícios
Authors: Dias Freires Jainni
Published: March 2023

O licuri, nativo da caatinga, apresenta polpa adocicada e amêndoas comestíveis ricas em óleo que pode ser aproveitado tecnologicamente. Assim, objetivou-se realizar o monitoramento tecnológico do processamento do óleo de licuri a fim de visualizar o cenário atual e definir as perspectivas futuras. Foram utilizadas as bases de patentes do INPI e ESPACENET utilizando as denominações “Syagrus coronata”, “licuri” e “ouricuri”, além da palavra-chave “óleo” nos idiomas inglês e português. Também foram pesquisadas produções científicas utilizando as mesmas palavras-chave do levantamento de patente, através das bases Google acadêmico, Periódicos Capes e Scopus. Foram encontradas 15 patentes e 51 produções científicas referentes ao uso do óleo de licuri, tendo a primeira patente publicada na década de 70 e pouco mais da metade das produções científicas publicadas nos últimos 6 anos. Por ser naturalmente brasileiro, o país e seus inventores destacaram-se em inovação tecnológica acerca do uso do óleo de licuri. O referido óleo apresentou múltiplas aplicações, destacando-se, principalmente, na produção de cosméticos, alimentação animal, bem como no desenvolvimento de biocombustíveis, tendo como área menos aplicada a da indústria de alimentos. Apenas duas patentes estiveram relacionadas ao seu uso na dieta humana, sendo para produtos de panificação e suplementação alimentar. Diante disso, ainda há diversas possibilidades de inovação tecnológica com o uso do óleo de licuri, seja com atualizações nas áreas já estudadas ou sua aplicação em outros nichos de mercado, especialmente os de alimentos e saúde, considerando a importância de inovação nessas áreas.
Educação e cultura política antimilitarista: a contribuição dos movimentos sociais libertários e anarquistas
Authors: Mariana Fernando Bomfim
Published: March 2023

Este artigo trata de alguns pressupostos da educação e da cultura política antimilitarista, a partir de conceitos, significados e vivências cotidianas que residem nos movimentos sociais e nas produções científicas libertárias e anarquistas – pautados distintamente pela resistência antiautoritária e anticapitalista. Para isso, evidencio dinâmicas contrárias às guerras, ao militarismo e demais práticas de terrorismo de Estado, assinalando o significado político indissociável das lutas sociais que promovam a paz a partir da justiça social, igualdade, liberdade e outros valores que nos possibilite o reencontro com a arte de viver e o respeito radical aos seres humanos e à vida no planeta Terra.
Editor’s intro
Authors: Chernykh S. I.
Published: March 2023

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Distance learning potential of the teacher's additional vocational education system
Authors: Aldoshina M. I.
Published: March 2023

Introduction. In the modern socio-cultural and valeological situation, the problem of increasing the professional competence of a teacher in the system of additional professional education by means of distance learning becomes urgent. The purpose of the study is to develop a theory of distance learning and to substantiate the potential of the contextual situation in the system of additional professional education of a teacher.Purpose setting. Research objectives: to substantiate the methodological basis of the theory of distance learning by means of a contextual situation; to clarify the concept of «distance learning by means of a contextual situation»; to organize experimental work on the implementation of a distance learning model by means of a contextual situation in the additional professional education of a teacher.Methodology and methods of the study: a) theoretical: analysis and systematization of specialized research on the subject; b) empirical: quantitative and qualitative analysis of the data of rapid testing and interviews conducted among students of the Institute of Continuing Education of the Kursk State University, Institutes of Educational Development of Kursk and Orel regions; c) diagnostic: experiment, expert evaluation method, methods of statistical data processing.Results. The development of the theory of distance learning by means of the contextual situation in the system of additional professional education of a teacher is focused on maintaining a balance between the development of individual educational routes of students, which will positively affect the personification of the teacher»s education in post-university improvement, and further successful professional self-realization and the growth of professional and pedagogical competence with the synergetic effect of competence and contextual methodological approaches.Conclusion. Based on the results obtained, we generalize the potential of distance learning by means of using the contextual situation in the system of additional professional education of a teacher. The results of the study can be used by university teachers, graduate students, undergraduates to identify promising and effective pedagogical technologies at different levels of professional education of teachers.
Infection and Social Dislocation: Wellbeing Impacts of COVID-19 on Children and Young People - Perspectives of Rwandan Leaders
Authors: Abbott Pamela , Bingwaho Agnes , Cowan Eilidh , D'Ambruoso Lucia
Published: March 2023

COVID-19, the fear it engendered, and the policy measures to manage its spread have disproportionately impacted the wellbeing of children and adolescents (CAs). We present an intensive critical realist case study of the impact of COVID-19 on the health and wellbeing of CAs in Rwanda, seeing it as much a social and political crisis as a medical and public health one. To do this, we carried out interviews with a purposive sample of 25 leaders with a working knowledge of children and young people; they were more likely than the CAs themselves to observe changes across the CA population within their remit and more likely to be looking for general explanations rather than individual experiences. The findings show that CAs' responses to the changes wrought on their lives by Covid-19 were conditioned by their age, gender, social class and if they lived in urban or rural areas. However, Covid19 has not just revealed the structural weakness of the Rwandan health system but of education, social protection, child protection, employment, family, and financial systems. The pathway to (adverse) impacts of COVID-19 on CAs is conditioned by these institutions and their interactions together with structural socioeconomic inequalities both within Rwanda and globally.
Menstrual Attitudes in the U.S. and China: Insights from Mobile Menstrual Tracking Applications for Teenagers
Authors: Peng Sisi , Yang Yuyin , Haselton Martie G
Published: March 2023

Mobile software applications (apps) have transformed how individuals oversee and maintain their own health. One way that girls can monitor their menstrual cycles is through the increasingly widespread use of mobile menstrual tracking apps. This study aims to examine menstrual symptom tracking for adolescents in English and Chinese apps, exploring menstrual literacy, cross-cultural differences, and framing, or presentation, of symptoms. The mixed methods content analysis involved 15 popular free menstrual tracking apps in English (n = 8) and Chinese (n = 7). Quantitative analysis of qualitative data was conducted through manual coding of content and automatically analyzing sentiment, or emotional tone, using a computational approach. We found that: (1) Menstrual literacy on symptom management or treatment was generally insufficient, (2) There were more available emotional than physical symptoms in English than Chinese apps, (3) Symptoms were framed more negatively than positively, somewhat more in Chinese than English apps. Findings emphasize the importance of improving information in digital menstrual trackers. Our findings further reflect cultural differences in emotional expression and negative attitudes toward menstruation. Since adolescence is a critical developmental stage that requires ample support, digital menstrual trackers can uniquely shape attitudes and experiences, ultimately, empowering teenagers to better manage their menstrual health.
IRAPs in Combination with Highly Informative ISSRs Confer Effective Potentials for Genetic Diversity and Fidelity Assessment in Rhododendron
Authors: Wen Sulin , Zhao Hong , Zhang Manying , Qiao Guang , Shen Xiaohui
Published: March 2023

Rhododendron is well-known for the colorful corolla. Molecular marker systems have the potentials to elucidate genetic diversity as well as to assess the genetic fidelity in rhododendrons. In the present study, the reverse transcription domains of long terminal repeat retrotransposons were cloned from rhododendrons and used to develop inter-retrotransposon amplified polymorphism (IRAP) marker system. Subsequently, 198 polymorphic loci were generated from the IRAP and inter-simple sequence repeat (ISSR) markers, of which 119 were derived from the IRAP markers. It was justified that in rhododendrons, IRAP markers were superior to the ISSRs in some polymorphic parameters such as the average number of polymorphic loci (14.88 versus 13.17). In comparison with the single one, the combination of IRAPs and ISSRs systems was more discriminative for detecting 46 rhododendron accessions. Further, IRAP markers demonstrated more efficiency in genetic fidelity detection of in vitro R. bailiens, an endangered species just recorded in Guizhzhou Province, China. The available evidences revealed the distinct properties of IRAP and ISSR markers in the rhododendron-associated applications, and highlighted the availability of highly informative ISSR and IRAP markers in the genetic diversity evaluation and the genetic fidelity assessment of rhododendrons, which may facilitate the preservation and genetic breeding in rhododendron plants.
Exploring Routes to Enhance the Calculation of Free Energy Differences via Nonequilibrium Work SQM/MM Switching Simulations by Using Hybrid Charge Intermediates Between MM and SQM Level of Theory or Non-linear Switching Schemes
Authors: Schoeller Andreas , Woodcock H Lee , Boresch Stefan
Published: March 2023

Nonequilibrium work switching simulations and Jarzynski’s equation are a reliable method to compute free energy differences, ΔAlow→high, between two levels of theory, such as a pure molecular mechanical (MM) and a quantum mechanical/molecular mechanical (QM/MM) description of a system of interest. Despite the inherent parallelism, the computational cost of this approach can quickly get very high. This is particularly true for systems where the core region, the part of the system to be described at different levels of theory, is embedded in an environment, such as explicit solvent water. We find that even for relatively simple solute–water systems, switching lengths of at least 5 ps are necessary to compute ΔAlow→high reliably. In this study, we investigate two approaches towards an affordable protocol, with emphasis on keeping the switching length well below 5 ps. Inserting a hybrid charge intermediate state with modified partial charges which resembles the charge distribution of the desired high level makes it possible to obtain reliable calculations with 2 ps switches. Attempts using step-wise linear switching paths, on the other hand, did not lead to improvement, i.e., faster convergence for all systems. To understand these findings, we analyzed the solutes’ properties as a function of partial charges used, the number of waters in direct contact with the solute, and studied the time needed for water molecules to reorient themselves upon a change in the solute’s charge distribution.
Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson
Authors: Tassone Annalisa , Meringolo Maria , Ponterio Giulia , Bonsi Paola , Schirinzi Tommaso , Martella Giuseppina
Published: March 2023

Much evidence suggests a correlation between degeneration and mitochondrial impairment. Typical cases of degeneration can also be observed in physiological phenomena (aging) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have as a common denominator the dyshomeostasis of mitochondrial bioenergy.
Even neurodegenerative diseases show a bioenergetics imbalance in their pathogenesis or progression. Huntington's chorea and Parkinson's disease are both neurodegenerative diseases, but while Huntington's disease is a genetic, and progressive disease with early manifestation and severe penetrance, Parkinson's disease is a pathology with a multifactorial aspect. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early onset diseases linked to gene mutation, others can appear in young adults and senescent only post-injury, and a final group is idiopathic.
Huntington's was defined as a hyperkinetic disorder, while Parkinson's is a hypokinetic disorder; but in the middle, there are a lot of similarities as well as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc.
In the review, we would embrace the theories that both diseases start and develop in light of mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.
Risk Factors of Breast Cancer Recurrence in Pathologic Complete Response Achieved by Patients Following Neoadjuvant Chemotherapy
Authors: Choi Joon Young , Woen Doyoun , Jang Sung Yoon , Lee Hyunjun , Shin Dong Seung , Kwak Youngji , Chae Byung Joo , Yu Jonghan , Lee Jeong Eon , Kim Seok Won , Nam Seok Jin , Ryu Jai Min
Published: March 2023

Background: Pathologic complete response (pCR) of breast cancer after neoadjuvant chemotherapy (NAC) is highly related to molecular subtypes. Patients who achieved tumor pCR after NAC have a better prognosis. However, despite of better prognosis, pCR patients have a potential for recurrence. There is little evidence of risk factors of recurrence in patients with pCR. We aim to analyze factors associated with tumor recurrence in patients who achieved pCR. Methods: This study retrospectively reviewed the data of patients diagnosed with breast cancer who achieved pCR after receiving NAC between January 2009 and December 2018 in Samsung Medical Center. pCR was defined as no residual invasive cancer in the breast and axillary nodes even if there is residual ductal carcinoma in situ (ypT0 or ypTis with ypN0). Breast cancers are classified into 4 subtypes based on hormone receptors (HR) and human epithelial growth factor receptor 2 (HER2) status. Patients who had bilateral breast cancer, inflammatory breast cancer, distant metastasis, unknown subtype, and histologically unique case were excluded from the study. Results: In total 483 patients were included in this study except for patients who corresponded to the exclusion criteria. The median follow-up duration was 59.0 months (range, 0.5-153.3 months). Breast cancer recurred in 4.1% of patients (20 of 483). There was a significant difference in clinical T (p = .004) and clinical N (p = .034) stage in the Kaplan-Meier curve for disease-free survival. Molecular subtypes (p = .573), Ki67 (p = 1.000), and breast surgery type (p = .574) were not associated with tumor recurrence in patients who achieved pCR after NAC. In the clinical T stage and clinical N stage, there was a significant difference between recurrence and no-recurrence groups (clinical T stage; p = .045, clinical N stage; p = .002). Univariable Cox regression revealed statistical significance in the clinical T stage (p = .049) and clinical N stage (p = .010), while multivariable Cox regression demonstrated non-significance in the clinical T stage (p = .320) and clinical N stage (p = .073). Conclusion: Results in this study showed that clinical T, clinical N stage, and molecular subtypes were not statistically significant predictors of recurrence in patients who achieved pCR after NAC. It is hypothesized that a multicenter-based study would lead to the identification of factors as predictors of recurrence after achieving pCR.
Pendanaan dalam Pencapaian Akses Universal Air Minum di Indonesia
Authors:   Program Studi Magister Perencanaan dan Kebijakan Publik Universitas Indonesia, Sudarsono Ratria Anggraini , Nurkholis Nurkholis ,   Fakultas Ekonomi dan Bisnis Universitas Indonesia
Published: March 2023

RPJMN 2015–2019 mengamanatkan pencapaian akses universal air minum tahun 2019. Penelitian ini menganalisis pencapaian kebijakan tersebut menggunakan regresi data panel. Random Effect Model (REM) menunjukkan variabel pendanaan, PDRB per kapita, dan kepadatan penduduk mampu menjelaskan variabel cakupan air minum sebesar 23,57%, sementara sisanya dijelaskan variabel di luar model. Variabel PDRB per kapita berpengaruh terbesar pada cakupan air minum, diikuti kepadatan penduduk. Untuk pendanaan, APBN signifikan memberikan pengaruh tertinggi pada cakupan air minum, diikuti APBD. Investasi berpengaruh positif, namun tingginya investasi per kapita belum tentu memberikan tambahan cakupan air minum tinggi.
Keterkaitan Spasial di Enam Negara Asia: Analisis Input-Output Dunia
Authors:   Fakultas Ekonomi dan Bisnis, Universitas Muhammadiyah Prof. Dr. HAMKA, Jakarta, Muchdie M. , Imansyah M. Handry ,   Fakultas Ekonomi, Universitas Lambung Mangkurat, Banjarmasin, Prihawantoro Socia ,   Kedeputian Bidang Pengkajian Kebijakan Teknologi, BPPT, Jakarta
Published: March 2023

Artikel ini menyajikan hasil analisis keterkaitan spasial di enam negara Asia, berdasarkan perhitungan efek limpahan dan efek balik pada tabel input-output dunia, yang diagregasikan untuk enam negara Asia, yang meliputi Cina, Indonesia, India, Jepang, Korea, dan Taiwan ditambah Australia, Amerika Serikat, dan the Rest of the World. Hasil analisis memperlihatkan bahwa, pertama, pengganda output di enam negara Asia cenderung meningkat dalam waktu 2000–2014. Ini merupakan indikasi pertumbuhan ekonomi yang konsisten. Kedua, kecuali di Cina, efek limpahan juga cenderung meningkat. Ketiga, tahun 2000, negara yang paling besar menikmati limpahan adalah Amerika Serikat dan Jepang, tetapi tahun 2014, limpahan terbesar beralih ke Cina. Keempat, efek balik yang terbesar terjadi di Cina dan Jepang. Efek balik terkecil terjadi di India dan Indonesia. Cina mempunyai efek limpahan terkecil tetapi menerima efek balik terbesar.
Perkembangan Teknologi Informasi, TFP, dan Emisi Gas CO2 di Indonesia
Authors:   Program Studi Ekonomi Pembangunan Fakultas Ekonomi dan Bisnis Universitas Ahmad Dahlan, Moddilani Ganiko , Irwandi Irwandi ,   Jurusan Ilmu Ekonomi Fakultas Ekonomika dan Bisnis Universitas Gadjah Mada
Published: March 2023

Penelitian ini menjelaskan pengaruh perkembangan teknologi informasi, total faktor produktivitas (TFP), dan urbanisasi terhadap emisi gas CO2 di Indonesia dari tahun 1975–2014. Untuk menguji secara empiris, penelitian ini menggunakan model Autoregressive Distributed Lag (ARDL). Ada beberapa hasil dalam penelitian ini. Pertama, koefisien nilai TFP pada jangka pendek lebih rendah daripada nilai koefisiennya pada jangka panjang sehingga penelitian ini menunjukkan bahwa hipotesis Enviromental Kuznets Curve (EKC) tidak terbukti. Hal ini menjadi salah satu penyebab naiknya emisi gas CO2. Kedua, teknologi informasi memiliki dampak yang signifikan terhadap naiknya emisi gas CO2. Ketiga, urbanisasi di Indonesia mengurangi emisi gas CO2.
Pola Perdagangan Global pada Perusahaan-Perusahaan Berteknologi Tinggi
Authors:   Fakultas Ekonomi dan Bisnis Universitas Airlangga, Sari Dyah Wulan , Restikasari Wenny ,   Fakultas Ekonomi dan Bisnis Universitas Airlangga
Published: March 2023

Penelitian ini menggunakan data tingkat perusahaan pada industri manufaktur berteknologi tinggi di Indonesia untuk menentukan kemampuan produksi suatu perusahaan, dari berbagai variabel perdagangan global, seperti intensitas ekspor, perdagangan vertikal yang terintegrasi, dan perdagangan dua arah terhadap. Penelitian ini menggunakan pendekatan generalized method of moment (GMM) untuk menguji faktor terpenting dari fenomena perdagangan global. Pada sampel penuh, hasil penelitian menunjukkan bahwa perdagangan vertikal yang terintegrasi dan perdagangan dua arah merupakan faktor penentu yang signifikan terhadap kemampuan produksi perusahaan sedangkan intensitas ekspor tidak. Pada sub-sampel pedagang biasa, intensitas ekspor merupakan faktor penentu yang signifikan terhadap kemampuan produksi perusahaan, sedangkan pada sub-sampel pedagang vertikal intensitas ekspor bukan merupaka faktor penentu.
Pengaruh Volatilitas Makroekonomi terhadap Alokasi Kredit Bank
Authors:   Departemen Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis, Universitas Indonesia, Colin Simanjuntak Ronald , Kacaribu Febrio ,   Departemen Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis, Universitas Indonesia
Published: March 2023

Penelitian ini membahas dampak volatilitas makroekonomi terhadap alokasi kredit bank. Hipotesis yang dibangun bahwa volatilitas makroekonomi akan memengaruhi bank bersikap hati-hati dalam menerbitkan kredit baru. Penelitian ini menggunakan data panel dengan sampel sepuluh bank dengan menggunakan Model Baum. Penelitian ini menggunakan volatilitas makro ekonomi sebagai variabel bebas. Penelitian ini menggunakan uji regresi generalized method of moment untuk meneliti hubungan antara variabel dependen dan bebas. Hasil dari penilitian ini menunjukkan adanya hubungan negatif antara volatilitas inflasi dan volatilitas pertumbuhan GDP dengan penyaluran kredit, sedangkan untuk volatilitas depresiasi nilai tukar tidak memiliki pengaruh terhadap penyaluran kredit.
Pengaruh Kesetaraan Gender terhadap Ketimpangan Capaian Pendidikan di Indonesia Tahun 2015–2019
Authors:   Badan Pusat Statistik Kabupaten Bolaang Mongondow, Yuniar Aninditya , Yuniasih Aisyah Fitri ,   Politeknik Statistika STIS
Published: March 2023

Pendidikan merupakan salah satu modal manusia yang sangat mendasar. Hak untuk memperoleh pendidikan diatur dalam UUD 1945 dan program wajib belajar sudah digalakkan pemerintah namun nyatanya rata-rata lama bersekolah penduduk Indonesia masih cukup rendah. Hal ini diduga akibat adanya ketimpangan capaian pendidikan penduduk. Metode analisis dalam penelitian ini menggunakan analisis data panel FEM dengan metode estimasi FGLS–SUR. Hasil penelitian menemukan bahwa ketimpangan pendidikan di Indonesia tergolong ke dalam kategori ketimpangan rendah selama 5 tahun terakhir dan dipengaruhi secara signifikan oleh kesetaraan gender, anggaran pemerintah, tingkat pengangguran, dan rasio Gini.
Indikator Makroekonomi dalam Perspektif Sentimen Media Massa Internasional di Negara ASEAN
Authors:   Politeknik Negeri Samarinda, Sukmana Eman , Musdalifah Musdalifah ,   Politeknik Negeri Samarinda, Amaludin Bakhtiar ,   Sekretariat Jenderal Kemenkeu, Nurcahyo Anton ,   Politeknik Negeri Samarinda
Published: March 2023

Penelitian ini dilakukan untuk menganalisis pengaruh sentimen media massa internasional terhadap indikator makroekonomi di lima negara ASEAN, yaitu Indonesia, Malaysia, Thailand, Singapura, dan Brunei Darussalam. Tujuan dari penelitian ini untuk mengembangkan model prakiraan makroekonomi berdasarkan hasil analisis indeks makroekonomi dan sentimen internasional yang menggabungkan data GDELT dan Indikator Perkembangan Dunia. Hasil penelitian menyebutkan bahwa setiap variabel indeks ekonomi memiliki korelasi terhadap variabel sentimen berita. Indikator yang paling berkorelasi dengan variabel sentimen berita, yaitu Current Account Balance (CAB) (0.777628), Foreign Direct Investment (FDI) (0.727840), dan Inflasi (-0,223941). Oleh karena itu, pembuat kebijakan ekonomi (pemerintah setiap negara) dan pelaku pasar mengandalkan beragam model yang menggabungkan informasi lunak yang mencakup ukuran subjektif mengenai sikap tentang kondisi ekonomi saat ini dan masa depan.
Tuberkulosis di Indonesia: Apakah Status Sosial-Ekonomi dan Faktor Lingkungan Penting?
Authors:   Universitas Pertamina, Kusumaningrum Amalia , Wulandari Grace ,   Universitas Pertamina, Kautsar Achmad ,   Universitas Pertamina
Published: March 2023

Tujuan dari penelitian ini adalah untuk melihat status sosial ekonomi dan faktor lingkungan terhadap tuberkulosis di Indonesia dengan menggunakan data Indonesian Family Life Survey (IFLS) tahun 2014. Tahap pertama, analisis karakteristik individu dengan metode regresi logistik. Tahap kedua, estimasi status sosial ekonomi dengan memasukkan koreksi dari hasil tahap pertama. Sementara itu, pada tahap ketiga menambahkan faktor kondisi lingkungan rumah dan memasukkan koreksi dari hasil tahap sebelumnya. Studi ini menemukan faktor pendapatan rumah tangga memengaruhi kejadian tuberkulosis, terutama rumah tangga yang memiliki pendapatan kurang dari Rp600.000. Selain itu, tingkat pendidikan, khususnya SMA dan perguruan tinggi, juga berpengaruh signifikan terhadap tuberkulosis. Sementara itu, faktor kondisi lingkungan rumah yang tidak layak tidak berpengaruh signifikan.
Analisis Kesalahan Siswa dalam Menyelesaikan Soal Cerita pada Materi Aritmatika Sosial Berdasarkan Tahapan Newman's Error Analysis (NEA) Kelas VII SMP NEGERI 187 JAKARTA
Authors: WT Wiranti , Meiliasari  , Dhianti Leny
Published: March 2023

Penelitian ini bertujuan untuk mendeskripsikan apa saja jenis kesalahan yang dilakukan siswa dan faktor penyebab siswa melakukan kesalahan dilihat dari aspek keterampilan siswa dalam menyelesaikan soal cerita pada materi aritmatika sosial berdasarkan tahapan  Newman’s Error Analysis (NEA) Metode yang digunakan dalam penelitian ini yaitu metode penelitian deskriptif kualitatif. Subjek yang dipilih dalam penelitian ini sebanyak 8 siswa, dengan kriteria: 4 siswa yang melakukan kesalahan yang banyak dilakukan oleh siswa lain dan 4 siswa yang melakukan kesalahan yang unik atau berbeda dengan siswa lain. Teknik pengumpulan data dilakukan melalui tes tertulis dan wawancara. Tes tertulis diadakan secara offline, sedangkan wawancara dilaksanakan secara online melalui aplikasi Zoom. Hasil penelitian menunjukan bahwa jenis-jenis kesalahan yang dilakukan siswa dalam menyelesaikan soal cerita aritmatika sosial diantaranya: 1) Kesalahan membaca; 2) Kesalahan memahami masalah; 3) Kesalahan transformasi; 4) Kesalahan keterampilan proses; 5) Kesalahan penulisan jawaban akhir. Terdapat 4 faktor penyebab kesalahan ditinjau aspek keterampilan siswa yakni dari segi: 1) linguistik: penguasaan kata/kalimat yang kurang baik dan belum matang, tidak bisa menyusun kata yang dipikirkan sesuai dengan pemahaman terhadap maksud soal; 2) perseptual: membaca dengan teknik superficial reading (membaca dangkal), kurang memilki keterampilan dalam menentukan posisi nilai tempat pada suatu bilangan; 3) berhitung: tidak menguasai keterampilan pada operasi pada matematika, kurang berlatih menyelesaikan soal cerita dengan variasi yang berbeda; 4) atensional: kekurang cermatan, tidak memahami apa yang diminta pada soal.
Liability of Mining Companies Related to Environmental Pollution in the Perspective of Prophetic Law
Authors: Suciati St. Muslimah , Sarif Asri , Rasmuddin  , Arfa Arfa
Published: March 2023

This study aims to analyze aspects of mining company liability related to environmental pollution in the perspective of prophetic law. A review of prophetic law is used as an analytical knife to confirm the existence of prophetic law, one of which emphasizes "unity" between the interests of humans and the universe (including the environment). This research is a normative legal research by prioritizing the concept and statutory approach. The results of the study confirm that proper legal responsibility for mining companies if it is proven that there is environmental pollution in a preventive manner or prevention, mining companies need to anticipate that before mining companies carry out mining activities, they must submit a post-mining reclamation plan and provide a post-mining reclamation guarantee fund. Then in the implementation of mining activities supervision must be carried out continuously and negotiate/persuade or supervise so that mining companies carry out their mining activities in compliance with permit conditions and other conditions for carrying out environmentally sound mining activities. Viewed from the perspective of prophetic law, legal accountability for mining companies in relation to environmental pollution is actually in accordance with three aspects of prophetic law, namely aspects of transcendence, humanization, and liberation. Therefore, in order to make law enforcement effective regarding legal liability for mining companies in relation to environmental pollution, it is necessary to harmonize and synchronize laws and regulations as well as the need for efforts to maintain coherence between statutory regulations and practice in the field.
Widening participation students’ experience and perception of flipped learning statistics compared with traditional teaching in higher education
Authors: Mathias Jinhua , Walczak Izabela , Leech Stephen
Published: March 2023

This paper presents data from a study comparing student experience and attainment when teaching statistics using Traditional Teaching (TT) and Flipped Learning (FL) approaches on a Foundation level module at a UK university. A survey of students’ experience and perception of FL was conducted at the end of the year. The results showed that the students liked the flexibility of FL and believed that studying asynchronously encouraged them to improve their independent learning skill and motivated them to search for more information for the subject, a finding broadly supported by other studies (Price and Walker, 2021). However, what was surprising, is that students believed they learned ‘better’ with TT than with FL, a perception supported by student overall attainment data. The study concludes that careful considerations must be made to make FL effective. These include the student demographic and their mathematics competency, the module contents and difficulty level. Otherwise, the use of FL may reduce students’ engagement and academic performance in Maths at Foundation level.
Potencial del biochar para la remediación de suelos contaminados con metales
Authors:   , Huillca Huanaco Ccoscco Eduardo
Published: March 2023

La contaminación de los suelos por metales pesados y metaloides es uno de los principales problemas del último siglo debido a la intensificación de diversas actividades como la minería, agricultura y metalurgia; se ha reportado la bioacumulación de metales en hortalizas, peces y aves, debido a un incremento de su movilidad y biodisponibilidad en el medio. Ante este problema, en este estudio se explora el potencial del biochar como una tecnología exitosa y sostenible que posee la capacidad de inmovilizar metales en el suelo gracias a los procesos de sorción que ocurren en la interacción metal-biochar que involucra diversos mecanismos fisicoquímicos dominados por fuerzas electrostáticas, siendo los parámetros más influyentes en las propiedades del biocarbón, la materia prima y la temperatura de pirólisis. Asimismo, el empleo de este producto rico en carbono también puede mejorar las propiedades fisicoquímicas y biológicas del suelo, garantizando la seguridad alimentaria y la salud pública; por último, el biocarbón representa una alternativa de mitigación y adaptación ante el cambio climático debido a su potencial de secuestro de carbono.
Enfermedades gastrointestinales más comunes en hurones (Mustela putorius furo)
Authors:   , Falcón Enciso Antony Odoniel
Published: March 2023

Se presenta una revisión actualizada sobre las enfermedades gastrointestinales más comunes en los hurones domésticos (Mustela putorius furo). Se recopiló información proveniente tanto de artículos científicos como de literatura gris. La revisión permitió clasificar a estas enfermedades en infecciosas y no infecciosas. Dentro de las infecciosas se describe a la coccidiosis, enteritis por coronavirus e infecciones bacterianas, mientras que en enfermedades no infecciosas se describe a de la Enfermedad Inflamatoria Intestinal (IBD) y la obstrucción por cuerpo extraño. Se resumen los siguientes aspectos sobre cada enfermedad: etiología, factores predisponentes, signos clínicos, diagnóstico, tratamiento y prevención. Todas estas enfermedades pueden considerarse para realizar diagnósticos diferenciales puesto que comparten signos clínicos similares y solo con determinadas pruebas se puede llegar al diagnóstico definitivo.