bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence de la motivation au travail des agents sur la performance du centre de santé de référence de la commune III du district de Bamako
Authors: Traoré Yaya , Belem Yacouba , Traoré Hawa
Published: February 2025

The demotivation of agents at work negatively affects the functioning of health structures. The resolution of this problem requires in-depth investigations to identify the real causes and propose adequate solutions. This study aims to analyse the factors of demotivation at work of the staff of the CSRéf of Commune III of the district of Bamako and the impact of their motivation on the performance of the structure. We carried out a qualitative study with 23 agents through semi-directive interviews, a documentary review and a content analysis according to Miles and Huberman (2003). The study's results made it possible to identify demotivation factors at the organization of services such as the inadequacy and insufficiency of consultation and hospitalization rooms, the irregularity of continuing training, low salaries and the career management of community agents.On the other hand, certain factors such as schedules and workload, internal communication, the choice of training participants and the adequacy of themes, the management of discounts and the career of government employees contribute to good motivation of employees. Concerning hierarchical superiors' management style, most employees were satisfied with decision-making, social relations and conflict management. According to employees, motivation at work has a positive impact on the performance of the CSRéf. Therefore, adopting an exemplary motivation system for employees inspired by this study is essential for the CSRéf.
Analysis of Spatial-Temporal Patterns of Wildfire Susceptibility in Queen Elizabeth National Park (QENP) - Uganda
Authors: Irumba Derrick Robert , Gidudu Anthony , Kayondo Lydia Mazzi
Published: February 2025

This study determined the variability of wildfire susceptibility in Queen Elizabeth National Park (QENP) in space and time. QENP is a protected area in Western Uganda. MODIS and VIIRS data for a six-and-a-half-year period from January 2015 - June 2021 were obtained to create an inventory of past fires. From these fires, spatial and temporal patterns were derived from exploratory spatial data analyses. The Weights of Evidence (WOE) method, a Bayesian form of statistical modelling, was used to determine the relationship between fires and wildfire conditioning factors, as well as to model wildfire susceptibility. Results of the study showed that the occurrence of wildfires within the study area vary seasonally. Sixty-one percent (61%) of the fires were observed to occur in the first dry season of the year, while thirty-one percent (31%) of the fires were observed to occur in the second dry season. Among the wildfire conditioning factors, altitude, vegetation (as measured by NDVI), and proximity to lakes indicated the highest correlation with the occurrence of fires. These conditions were attributed to physiographic influences, water stress in vegetation, and the socio-economic activities of the fishing villages around the lakes respectively. From the derived wildfire susceptibility maps, varying levels of wildfire susceptibility were determined. Proportional values of 19% and 20% of the study area were classified with very high and high susceptibility levels respectively. The remaining 61% of the study area was covered by moderate, low, and very low susceptibility levels. The study results provided vital findings about the seasonal patterns of wildfire occurrence, factors influencing the occurrence of wildfires and the locations most susceptible to wildfires. This information will enable managers to allocate fire management resources optimally to efficiently mitigate against wildfires within QENP.
Looking at the Draft and Thinking the Environs. Exercises in Genetic Criticism
Authors: Antoniuk Mateusz
Published: February 2025

The essay is devoted to the following problem: how is it possible to search for a link between genetical analysis of the rough draft and the reflection about the spatial and social surroundings, within which the creative action took place. “Environment” here is understood, firstly, as the very same sheet of paper, used by the author to create the poem, secondly, as the interpersonal and social relation, that stimulates (but also limits) creative subject’s activity, thirdly, as the “hospital”, what means: a material space, an institution and a social situation), in which the creative subject strives to preserve their subjectivity. As the cases studied in this kind of “regime of interpretation” serve the working manuscript left by three major Polish poets of twentieth century: Czesław Miłosz, Tadeusz Różewicz and Zbigniew Herbert.
“Observe, Decrypt, Inform” – Working on a Walking Performance
Authors: Burzyńska Anna R.
Published: February 2025

The article deals with the creative process of creating a so-called walking performance. The analysed case study is the performance Skrót. Krakau Files [Short Cut. The Krakau Files, 2003] produced by Goethe-Institut in Kraków and created by the Swiss theatre director, Stefan Kaegi. The work on the performance is described from two perspectives. The first is internal (creative) – the author co-created the dramaturgy of the project and supervised its proper exploitation. The second is external (critical, exploratory, research-related). It includes references not only to existing theories of walking performance and audio walk but also to ideas such as flâneurism (as seen by Charles Baudelaire and Walter Benjamin), psychogeography, the drift, the writings of Michel de Certeau, Guy Debord and the Situationists.
$\mathcal{S}$-adic characterization of minimal dendric shifts
Authors: Gheeraert France , Leroy Julien
Published: February 2025

Dendric shifts are defined by combinatorial restrictions of the extensions of the words in their languages. This family generalizes well-known families of shifts such as Sturmian shifts, Arnoux-Rauzy shifts and codings of interval exchange transformations. It is known that any minimal dendric shift has a primitive $\mathcal{S}$-adic representation where the morphisms in $\mathcal{S}$ are positive tame automorphisms of the free group generated by the alphabet. In this paper we give an $\mathcal{S}$-adic characterization of this family by means of two finite graphs. As an application, we are able to decide whether a shift space generated by a uniformly recurrent morphic word is (eventually) dendric.

Comment: 36 pages
The Inappropriate Photoreceptor Depolarization May Give Rise to Age-Related Macular Degeneration: Clinical Evidence
Authors: Magonio Fabrizio
Published: February 2025

Age-related Macular Degeneration (AMD) is a complex, multifactorial, progressive retinal disease that affects millions of people worldwide. Alterations in phototransduction, renewal of the outer segments of photoreceptors, visual transduction and retinol metabolism have a major impact on retinal health.

Mutations within any of the molecules responsible for these visual processes cause different types of degenerative retinal diseases. Increase in membrane potential caused by accidental binding to a foreign molecule, increased temperature or ocular pressure could trigger an electrochemical overload in the photoreceptor which would be inappropriately depolarized. The signs of this process are clearly visible with Optical Coherence Tomography (OCT): hyper-reflective vertical lines that cross the choroid at the points of interruption of the ellipsoid zone resulting in atrophy and compromise of the outer hematoretinal barrier.

The occasional finding of these lines would represent the first clinical sign of a degenerative process which could subsequently give rise to those events characterizing AMD.
Quercetin inhibits largemouth bass rhabdovirus infection by enhancing the immune response in Micropterus salmoides
Authors: Xue Mingyang , Jiang Yangyang , Xu Chen , Huang Zhenyu , Jiang Nan , Li Yiqun , Meng Yan , Fan Yuding , Zhou Yong
Published: February 2025

The Largemouth bass Rhabdovirus (LMBRaV) is a highly virulent pathogen that results in substantial mortality rates and economic losses within the largemouth bass (Micropterus salmoides) aquaculture industry. The utilization of medicinal plant extracts has emerged as a promising strategy for combating aquatic animal diseases. In this study, we aimed to evaluate the anti-LMBRaV properties effects of nine plant-derived compounds utilizing EPC cells and largemouth bass. Among them, quercetin demonstrated a notable inhibitory effect on LMBRaV replication in EPC, with a reduction of 93.6% at 20 mg/L. Quercetin exerts its anti-LMBRaV properties on cells may result from its ability to inhibit viral entry, mitigate nuclear damage, and inactivate the virus directly. In vivo experiments showed that the preventive protection rate of quercetin against LMBRaV infection in largemouth bass reached 57.7%, and decreased LMBRaV viral loads in liver, spleen and kidney. Moreover, quercetin appeared to induce the expression of several immune-related genes, including interferon (IFN), and major histocompatibility complex 1 (MHC-1), myxovirus resistance 1 (MX1), and nuclear factor erythroid 2-related factor 2 (Nrf2), suggesting its potential for immunoregulation. Furthermore, quercetin mitigated the pathological alterations in the immune organs of largemouth bass infected with LMBRaV. In summary, quercetin shows promise as an immunomodulatory agent against LMBRaV infections in largemouth bass.
A perspective on Paul Younger’s work on the Newcastle Science Central Deep Geothermal Borehole and new developments from the NetZero GeoRDIE project
Authors: Brown Christopher S. , Kolo Isa , Falcone Gioia
Published: February 2025

Paul Younger, to whose memory this issue is dedicated, was an early advocate of a geothermal energy renaissance in the north of England. This paper offers background to the experience gained with the Eastgate BH1 and Eastgate BH2B boreholes, focused on exploring the geothermal potential of the Weardale Granite, followed by what has subsequently become known as the Newcastle Science Central Deep Geothermal Borehole (NSCDGB), which found a sequence of (presumed) Fell Sandstones. These efforts represent not only a legacy piece of the energy infrastructure in the UK, but also a legacy of Paul Younger. While the NSCDGB has not been developed using conventional geothermal methods, it has proved invaluable in providing data and a modelling test-bed for the geothermal potential of northern England and it is hoped that in future years it can serve as a testing facility for deep geothermal research. Research carried out as part of the recently concluded NetZero GeoRDIE has confirmed that it could still be converted to a Deep Borehole Heat Exchanger (DBHE), with an indicative total continuous heat yield of >50 kW for a lifetime of 25 years if repurposed to c.920 m depth.
Driving Growth in Healthcare Organizations through a Strategic Account Management Program
Authors:   USA, Taranekar Priyanka
Published: February 2025

This paper examines the implementation and impact of Strategic Account Management (SAM) programs in
healthcare organizations with a proposed framework as the solution to overcome limitations of traditional
SAM models. The study presents a comprehensive framework for developing and executing SAM programs,
focusing on seven key steps: strategic account identification, account profiling, internal resource alignment,
value co-creation, KPI establishment, change management, and continuous performance monitoring. The
paper also considers the economic impact of implementing the proposed framework with a case analysis
of a mid-sized healthcare organization with USD 100M in revenue. The impact assumptions include a 5%
year-over-year revenue growth, 1% increase in gross margin, and improved customer retention, resulting in
a significant economic benefit of USD 5.2 million increase in annual gross profit. The findings suggest that
SAM programs enable healthcare organizations to build stronger partnerships with high-value accounts,
enhance customer satisfaction, and maintain competitive advantage in an increasingly dynamic healthcare
landscape. This research contributes to the understanding of how healthcare organizations can transition
from transactional relationships to value-driven partnerships through structured account management
strategies.
Ultrasound Ablation Technology Medical Devices
Authors:   Staff Engineer, Medical Devices, Ablation Technology, Healthcare, MedTech, USA, Hiremath Somashekharayya
Published: February 2025

One of the most advanced developments in medical ablation technology is High-Intensity Ultrasound (HIU).
This technology offers precise and minimally invasive treatment for several ailments, such as breast cancer,
prostate cancer, and renal denervation (RDN). Technology uses ultrasound transducers to emit targeted
pressure waves that generate heat within tissues, resulting in localized ablation while sparing surrounding
areas. This paper explores the principles, applications, and advancements in ultrasound ablation, including
intravascular non-focused Ultrasound for RDN and the evolving role of HIU in oncological and non-oncological
treatments. In this paper, ultrasound ablation technology, HIU system designs, transducer materials, and
bench evaluations are addressed, and the effects and range, as well as the future of ultrasound ablation
technologies are explored in the field of medical devices and biomedical applications.
Enhanced Particle Swarm Optimization Algorithm for Cloud Computing Environments Workload Scheduling
Authors: Zeenath Sultana  , Dr. Raafiya Gulmeher  , Asra Sarwath
Published: February 2025

Because of cloud services' increased accessibility, enhanced performance, and affordability, cloud service providers are always looking for ways to speed up work completion in order to increase revenues and save energy costs. Even though many scheduling algorithms have been developed, many of these methods only focus on one aspect of the scheduling process. An innovative method called the Enhanced Particle Swarm Optimisation Algorithm (EPSOA) is put forward to effectively improve optimisation outcomes for the cloud workload scheduling issue. The PSO and the Lévy flight are integrated by EPSOA. The purpose of adding Lévy combat is to increase the PSO's search space and speed up convergence via adaptive crossover. The Cloudsim program is used to simulate and assess the EPSOA model under various test scenarios. By using a variety of factors and contrasting them with those of current algorithms, the efficacy of EPSOA is evaluated. The results show that EPSOA performs better than other algorithms in terms of execution cost, energy consumption, and resource usage, demonstrating its effectiveness in managing the difficulties associated with multi objective cloud job scheduling.
Advancing Solar Still Performance with Nano-Integrated Thermal Energy Storage Systems
Authors: Santosh kumar Gupta  , Devesh kumar
Published: February 2025

Obtaining safe drinking water is still a major worldwide concern, especially in resource-limited regions. Solar distillation provides an eco-friendly and cost-effective solution and this study advances the field by integrating innovative materials into hybrid solar still systems. By combining phase change materials (PCMs) such as stearic acid, lauric acid, and Paraffin wax with nanoparticles like CuO and TiO₂, the research introduces a groundbreaking approach to optimizing heat transfer and enhancing water productivity. The experimental setup features a solar still connected to a solar water heater, employing advanced materials to boost energy efficiency and distillate output. This novel integration significantly improves exergy performance, pushing the boundaries of conventional solar still technologies. The results reveal a transformative leap in water production efficiency, demonstrating the potential of sustainable, innovative solutions to tackle global water scarcity. This study redefines the capabilities of solar distillation systems, showcasing how the synergy between PCMs and nanoparticles can revolutionize water purification in a practical, scalable, and environmentally responsible manner.
Performance Analysis of 2D Dual-Gate MoTe2 FETs With High-k Dielectrics: A Comparative Study Of HfO2 And La2O3
Authors: Vikram Pratap Singh  , Surendra Kumar  , Shivam Verma  , Amritanshu Pandey
Published: February 2025

The proposed work uses MoTe2, a type of Transition Metal Dichalcogenide (TMD) channel material, to investigate a monolayer double-gated 2D-FET configuration. The monolayer double-gated 2D-FET structure is advantageous for ultra-large-scale integration and offers more control over subthreshold parameters. Additionally, these designs offer minimal leakage and excellent control over the channel's current. The design of a double-gated 2D-FET using High-K gate dielectric materials, such as lanthanum dioxide and hafnium oxide, as the gate oxide is covered in this study. A comparison of silicon dioxide transistors of the same size, Hafnium oxide and lanthanum oxide as the gate oxide is performed. The comparison primarily focuses on performance metrics such as transconductance, subthreshold slope, and drain current behavior. Using a High-K dielectric material leads to an increase in ON current, which in turn enhances other parameters such as the subthreshold slope, transconductance, and intrinsic gain.
Features of the selection of pathogenetic therapy in an elderly, comorbid patient with Crohn's disease
Authors:   Ulyanov Chuvash State University, Cheboksary, Russia, Tarasova Larisa V. ,   Republic Clinical Hospital, Cheboksary, Russia, Kucherova Nadezhda Yu. ,   Ulyanov Chuvash State University, Cheboksary, Russia; Republic Cardiology Dispensary; Cheboksary, Russia, Ivanova Daria A. ,   Ulyanov Chuvash State University, Cheboksary, Russia, Tsyganova Julia V. ,   Ulyanov Chuvash State University, Cheboksary, Russia
Published: February 2025

The article describes a clinical case and the importance of selecting pathogenetic therapy in an elderly comorbid patient with inflammatory bowel disease – Crohn's disease.
A clinical case of iron deficiency anemia in a patient with pulmonary arterial hypertension: a multidisciplinary problem
Authors:   Polyakov Samara Regional Clinical Cardiological Dispensary, Samara, Russia, Balkina Ksenia V. ,   Samara State Medical University, Samara, Russia, Pavlova Tatyana V. ,   Polyakov Samara Regional Clinical Cardiological Dispensary, Samara, Russia;
Published: February 2025

Recently, the correction of iron deficiency in patients with chronic heart failure has been widely studied to improve the prognosis and course of the disease. At the same time, there are not so many works devoted to the study of the use of iron preparations in patients with pulmonary arterial hypertension. Timely diagnosis and treatment of anemia or latent iron deficiency in patients of this category not only correct the symptoms of anemia, but also prevent the progression of the disease. However, at present, in real clinical practice, parenteral iron preparations in patients with latent iron deficiency are rarely used, as a result of which active outreach among practitioners is necessary in order to expand the use of this type of treatment.
The role of decreased myocardial inotropic function in the development of cardiovascular complications in patients with chronic heart failure and pneumonia caused by Pseudomonas aeruginosa
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Tarzimanova Aida I. , Ponomareva Liubov A. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Popova Elena N. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Chinova Alina A. ,   Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russia, Ponomarev Andrey B. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Podzolkov Valery I. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: February 2025

Background. Chronic heart failure (CHF) is the final result of cardiovascular diseases and is difficult to treat. According to epidemiological studies, the prevalence of severe CHF phenotypes is increasing. To date, predictors of poor prognosis in patients with CHF and pneumonia caused by Pseudomonas aeruginosa (P. aeruginosa) have not been determined.
Objective. To assess the role of decreased myocardial inotropic function as a predictor of adverse cardiovascular complications in patients with CHF and pneumonia caused by P. aeruginosa.
Materials and methods. The study included 92 patients who were divided into a group of patients with pneumonia caused by P. aeruginosa (Group I) and a group of patients with pneumonia caused by Staphylococcus aureus (S. aureus) (Group II). All patients underwent routine general clinical examination, determination of NT-proBNP level, transthoracic echocardiography, electrocardiography, Doppler ultrasound of the deep veins of the lower extremities, chest and head CT scan.
Results. Cardiovascular complications occurred significantly more often in patients with CHF and pneumonia caused by P. aeruginosa than in patients with CHF and pneumonia caused by S. aureus. A decrease in left ventricular ejection fraction <40% was associated with a more severe course of the disease and a greater number of cardiovascular complications (OR 1.833, 95% CI 1.188–3.400; p<0.05).
Conclusions. Patients with CHF and P. aeruginosa-associated pneumonia are at greater risk of developing cardiovascular complications than patients with pneumonia caused by S. aureus. Reduced inotropic myocardial function is a reliable predictor of cardiovascular complications.
Keywords: heart failure, pneumonia, Pseudomonas aeruginosa.
Personalization of therapy in patients with atrial fibrillation: a case report
Authors:   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Ostroumova O.D. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Kochetkov A.I. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Litvinova S.V. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Filippova T.V. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia
Published: February 2025

A clinical case of a 65-year-old man with newly diagnosed AF is presented. The patient consulted a cardiologist because of a first-time paroxysm of atrial fibrillation (AF), which was stopped with medication in hospital (propafenone at a dose of 1.5 mg/kg intravenously for 10 minutes). It is known from the anamnesis that the patient suffers from arterial hypertension and stage I obesity, and previously suffered from gastric bleeding. According to esophagogastroduodenoscopy, chronic Helicobacter erosive active severe gastritis was detected. During the consultation, the patient was recommended anticoagulant therapy (apixaban 5 mg × 2 times a day), gastroenteroprotective therapy (rebamipide 100 mg × 3 times a day + rabeprazole 20 mg 2 times a day), antiarrhythmic therapy (propafenone 150 mg × 3 times) and H. pylori eradication therapy (clarithromycin 500 mg × 2 times a day, amoxicillin 1000 mg × 2 times a day). Using a specific clinical case as an example, the article discusses modern approaches to improving the safety of anticoagulant therapy and choosing a rhythm control strategy in patients with AF.
Infarction-like electrocardiogram during aortic dissection
Authors:   Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia, Tsibulskaya N.Yu. ,   Emergency Hospital named after. N.S. Karpovich, Krasnoyarsk, Russia, Harkov E.I. ,   Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Emergency Hospital named after. N.S. Karpovich, Krasnoyarsk, Russia, Ryabkov E.I. ,   Emergency Hospital named after. N.S. Karpovich, Krasnoyarsk, Russia, Kononovich U.A. ,   Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia, Mashintseva A.D. ,   Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia
Published: February 2025

A clinical example demonstrates the difficulties of differential diagnosis of infarct-like ECG during aortic dissection. The difficulty of diagnosis was the absence of pain, impaired consciousness of the patient, the presence of anisocoria, ECG changes simulating acute myocardial infarction with ST segment elevation, and the presence of obstructive changes in the coronary arteries according to the results of coronary angiography. The diagnosis was initially confirmed by aortography, then by multislice computed tomography of the aorta and echocardiography. Possible clinical diagnostic signs of aortic dissection are given.
FULLSCREEN > Archive > 2024 > Vol 5, №10 (2024) > Efficacy of fremanezumab in patients with chronic migraine and concomitant depression Efficacy of fremanezumab in patients with chronic migraine and concomitant depression
Authors:   Clinic of Professor Kinzersky, Chelyabinsk, Russia, Timokhovich A.Y. , Berdnikova A.V. ,   Alexander Vein Headache Clinic, Moscow, Russia; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Latysheva N.V. ,   Alexander Vein Headache Clinic, Moscow, Russia; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: February 2025

Background. Migraine is a common chronic disorder that ranks third in the disability-adjusted life years among nervous system disorders.
It is well known that migraine is strongly associated with the depression/anxiety disorders; there is overwhelming data suggesting common mechanisms underlying migraine and depression, including involvement of the neurotransmitter systems, such as calcitonin gene-related peptide (CGRP).
Aim. Efficacy of fremanezumab in patients with chronic migraine (CM) and concomitant depression.
Methods. A total of 48 patients aged 23–57 years with the established diagnosis of CM and depression took part in the study. Fremanezumab in a dose of 225 mg was administered monthly throughout 6 months. Clinical interviewing and headache diary assessment were performed every month, and the Hamilton Depression Inventory (Hamilton Depression Rating Scale) was filled during the first visit, on months 3 and 6.
Results. A significant decrease in the headache frequency with the steady increase of effect by month 3 of therapy and the effect persistence by month 6 of therapy is reported in patients with CM and depression. A significant decrease in the depression scores based on the Hamilton Depression Rating Scale is observed.
Conclusion. Fremanezumab can be used as one of the first-line drugs for treatment of patients with CM and concomitant depression.
Influencia de los hábitos alimenticios en el rendimiento académico de los estudiantes de Ingeniería Agroindustrial
Authors: Pantoja Tirado Lucia Ruth , Aguirre Vargas Elza Berta
Published: February 2025

Eating habits begin at an early age, but as students enter college, they develop changes in their eating styles. Early adulthood is an influential stage of life for developing healthy eating patterns. In the Ancash region, there is scarce information on the nutrition of university students. Therefore, the objective of the research was to determine the influence of eating habits related to the academic performance of students of Agroindustrial Engineering at the Universidad Nacional del Santa. The research was quantitative, the design used was descriptive, with a cross-sectional cut. A situational diagnosis was made with respect to eating habits, in order to develop strategies that promote healthy eating. Spearman correlation was used to evaluate the relationship between academic performance and eating habits. The results show that eating habits have a direct relationship with the academic performance of Agroindustrial Engineering students at the Universidad Nacional del Santa being this relationship very high (? = 0.940). University students should prioritize the intake of nutritious food, since their diet has a direct influence on their academic performance.
The Role of Corporate Communications in Enhancing Employee Engagement: A Structured Communications Approach for Various Use Cases
Authors: Rashed Rana
Published: February 2025

Purpose: The purpose of this research is to fill the gap in existing literature by examining employee engagement needs and how those needs can be addressed through corporate communication practices.
Methodology: The research will examine a Gallup Q12 survey report and analyse the employee engagement needs and how those needs relate to other aspects of the workplace culture. By synthesizing the findings from the literature and extracting insights from the secondary data, the study aim is to suggest a simple corporate communications model that can be implemented in the workplace to enhance employee engagement.
Findings: The study showed that the collective impact of the opportunity to do what can be done best, the commitment to the company’s purpose while having less close friends at work, has a positive impact on employee engagement – which draws attention to the need of balancing social connections with the needs of employee performance and commitment.
Unique Contribution to Theory, Practice and Policy: The research will suggest a corporate communications model that can be implemented in the workplace to enhance employee engagement. Recommendations may include effective use of the different communication channels, employee interactions, as well as understanding the impact of job satisfaction, commitment, and performance on employee engagement and how this relates to communication practices.
Motion of a Symmetric Top Analyzed by Circular Motion
Authors: Wang Weitao
Published: February 2025

When a symmetrical rigid top rotates on a plane, it will encounter resistance to prevent it from falling due to gravity. According to various theoretical inferences and practical proofs, the original vertical kinetic energy of the top is converted into horizontal kinetic energy because of unknown reason. I attribute this unknown reason to the horizontal circular motion of the top, and derive the specific movement trajectory of the top base on this, including three movement trajectories and their conditions.
Machine learning models accurately predict T-DNA insertion into plant genomes
Authors: Smith Sawyer , Agah Azin
Published: February 2025

Agrobacterium tumefaciens is a gram-negative bacterium of the family Rhizobiaceae and is known for its pathogenic ability to induce a neoplastic response in over 100 different species of plants, often leading to significant decline in individual plant health. The mechanism by which tumors are induced includes a segment of DNA contained within the bacterium’s Ti plasmid which is integrated in the host genome. The T-DNA is oncogenic, encoding enzymes that increase the production of certain plant hormones ultimately leading to tumor formation. The impressive ability of T-DNA to integrate into plant genomes has led to its use as a common method of genetic transformation in plants. While it has been documented that the T-DNA insertion occurs at double strand breaks, the mechanism of insertion still remains elusive. Currently, the point at which the T-DNA is inserted in the host genome is believed to be somewhat random with respect to the surrounding sequences, and uncontrolled multiple insertion sites appear to be a common phenomenon. In this study, we utilized machine learning algorithms to assess the nucleotide sequences that are important in integration of Ti plasmid into the host genome. Various machine learning algorithms have yielded high-accuracy models provided sequence data alone.
Music Therapy in Alzheimer’s Disease: Considerations for Implementation in Vietnam
Authors: Ly Tri Duc
Published: February 2025

Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for an estimated 60-70% of dementia cases. The disease is characterized by a progressive loss of cognitive function associated with an excessive number of senile plaques in the cerebral cortex and subcortical gray matter atrophy accompanied by Beta-amyloid and neurofibrillary tangles consisting of tau protein. While there has yet to be an effective treatment for Alzheimer’s disease, music therapy (MT) has shown promise for reducing a variety of symptoms. For instance, MT was able to reduce agitation, anxiety, and depression as well as aid cognitive, sensory, and socio-emotional abilities. Additionally, MT is easy to implement and well-tolerated by most patients and caregivers. However, MT is currently not widely prescribed in many countries, including Vietnam. We reviewed the literature on MT and dementia, with a focus on AD to better understand factors affecting MT efficacy and barriers to implementing MT for individuals with AD in Vietnam. Further research is warranted to gain a better understanding of factors affecting the efficacy of MT for individuals with AD, with considerations specifically for individuals with AD in Vietnam.
Mutant p53R175H-Associated Protection of Ovarian Cancer Precursor Cells from Cisplatin Requires Expression of SLC6A6 Taurine Transporter
Authors: Polotaye Teagan , Centeno Daniel , Iwanicki Marcin
Published: February 2025

Tumor suppressor gene TP53 is ubiquitously mutated in ovarian cancer precursor lesions that undergo pervasive accumulation of DNA damage. Prior literature provides evidence that the expression of mutant p53 protein in epithelial cells is associated with increased survival in response to DNA-damaging treatments.  Hence, identification and understanding of the mechanisms that, in response to DNA damage accumulation, support survival of ovarian cancer precursor cells carrying p53 mutations might provide important information about the evolution of the disease. Here we used a combination of OC precursor cell models, biochemistry, microscopy, and flow cytometry to provide evidence that the taurine transporter, the SLC6A6 molecule, contributes to cell protection from DNA-damaging (cisplatin) treatment. We found that expression of mutant p53R175H in OC precursor cells, the fallopian tube non-ciliated epithelial (FNE) cells, induced resistance to the DNA-damaging agent cisplatin. Most importantly, shRNA-mediated targeting of SLC6A6 transcript re-sensitized FNE cells expressing mutant p53R175H to cisplatin treatment. Our studies are consistent with the model that the loss of SLC6A6 alters mechanisms involved in the regulation of cell survival in response to DNA damage.
PERBANDINGAN METODE REGRESI LINEAR DAN K-NEAREST NEIGHBOR (KNN) DALAM MEMPREDIKSI PRODUKSI TANAMAN PADI DI PULAU SUMATERA
Authors: Hidayatullah Muhammad Reefy
Published: February 2025

Padi merupakan bahan pangan yang sangat penting untuk menunjang kebutuhan pangan di Indonesia, khususnya di Pulau Sumatera. Faktor-faktor yang memengaruhi produksi padi meliputi luas panen, kelembapan, curah hujan, dan suhu rata-rata. Setiap tahun, suhu bumi yang terus meningkat akibat pemanasan global berdampak pada iklim yang fluktuatif, sehingga dapat menghambat produksi padi. Memahami faktor-faktor tersebut menjadi penting untuk pengembangan strategi yang efektif dalam meningkatkan produktivitas padi. Penelitian ini menggunakan bahasa pemrograman Python pada Google Colab untuk membandingkan metode regresi linear berganda dan K-Nearest Neighbors (KNN) dalam memprediksi produksi padi di Pulau Sumatera. Hasil penelitian menunjukkan bahwa metode regresi linear lebih akurat dibandingkan KNN, dengan nilai R² regresi linear sebesar 0,868181, lebih unggul 18,94% dibanding KNN. Selain itu, regresi linear memiliki nilai MAE yang lebih rendah sebesar 22,03% dan nilai MSE yang lebih rendah sebesar 55,49% dibanding KNN. Hasil ini menunjukkan bahwa regresi linear lebih andal dalam memprediksi produksi padi di Pulau Sumatera dan dapat digunakan sebagai alat bantu dalam pengambilan keputusan strategis di sektor pertanian.
PENGEMBANGAN DAN IMPLEMENTASI APLIKASI PELAYANAN JASA BERBASIS WEB PADA CV ALTRAMA ENERGI
Authors: Gultom Ananda Christianto , Batubara Supina , Sitorus Zulham
Published: February 2025

Kualitas jasa layanan yang prima mampu menciptakan loyalitas konsumen sehingga dapat tercipta hubungan kerja yang saling menguntungkan antara kedua belah pihak. CV Altrama Energi adalah salah satu perusahaan layanan jasa penyewaan alat berat maupun perawatan atau perbaikannya untuk berbagai kebutuhan pekerjaan berat seperti konstruksi maupun pertanian. Dengan kondisi pengelolaan data yang tidak efektif mengakibatkan pimpinan CV Altrama Energi kesulitan melakukan pencarian data, pemantauan jadwal pekerjaan maupun penagihan. Hal ini dapat mempengaruhi reputasi CV Altrama Energi dimata konsumen yang dapat mengakibatkan terputusnya hubungan kerjasama dengan konsumen. Tujuan penelitian ini adalah mengembangkan dan mengimplementasikan aplikasi layanan jasa berbasis web untuk mengolah data jasa penyewaan dan jasa perbaikan alat berat pada CV Altrama Energi menggunakan metode prototipe, perancangan aplikasi menggunakan unified modelling language, dan pengujian menggunakan metode Black Box. Hasil penelitian ini menunjukkan bahwa metode prototipe cocok digunakan dalam pengembangan aplikasi di CV Altrama Energi karena seringnya terjadi perubahan kebutuhan serta aplikasi yang dihasilkan user friendly digunakan oleh pegawai administrasi maupun pimpinan CV Altrama Energi.
ROMANIA'S PROGRESS IN IMPLEMENTING SUSTAINABLE DEVELOPMENT GOAL 8 OF THE 2030 AGENDA. A STATISTICAL ASSESSMENT
Authors: IFTIMOAEI Ciprian , BACIU Ionuț-Cristian , GABOR Robert-Vicențiu
Published: February 2025

Initially, sustainable development was regarded as a response to the ecological crisis caused by the intensive industrial exploitation of resources and ongoing environmental degradation, with an emphasis on preserving environmental quality. Over time, the concept has broadened to encompass the complex notion of quality of life, integrating social, cultural, political, and economic dimensions. At its core, sustainability recognizes the dependence of human activities on the environment and its resources. Key elements such as health, social security, and macroeconomic stability are considered vital for ensuring a high quality of life. The 2030 Agenda for Sustainable Development, titled Transforming our World, was adopted by the UN General Assembly on September 25, 2015, with the support of leaders from 193 countries. This framework updates the vision of sustainable development through 17 Sustainable Development Goals (SDGs) and 169 specific targets. Romania, as one of the signatories, has been implementing its National Sustainable Development Strategy (2018-2030) since 2018. This work adopts an exploratory perspective to examine the progress made in achieving SDG 8 – Decent Work and Economic Growth – on global, European, and national levels. To analyze Romania's progress toward SDG 8, we will employ descriptive statistical methods and principal components analysis. The data, spanning the years 2008-2023, are sourced from the National Institute of Statistics and Eurostat. The findings of this study aim to support the assessment and monitoring of Romania's achievements under SDG 8 and to inform strategies and public policies that promote decent work and economic growth.
THE ROLE OF THE SOCIAL ECONOMY IN ACHIEVING SUSTAINABLE DEVELOPMENT OBJECTIVES
Authors: IFTIMOAEI Manuela , PETRESCU Claudia
Published: February 2025

The article explores the impact of the social economy in Romania on the achievement of the Sustainable Development Goals (SDGs) of the UN 2030 Agenda, considering the specific contributions of different types of social economy organizations in achieving sustainable results. These organizations include: economically active NGOs (operating under Government Ordinance No. 26/2000, Law No. 246/2005), licensed social enterprises (operating under the Social Economy Law No. 219/201) and licensed protected units (operating under Law 448/2006 on the protection and promotion of the rights of persons with disabilities). The paper aims to assess the contribution of these economic entities to sustainable development by identifying their specific activities that influence progress towards the achievement of the SDGs. Comparative analysis of different types of organizations helps to understand how each contributes to different aspects of sustainable development.
The study was based on updated data from the Register of Associations and Foundations (published on the website of the Ministry of Justice), the National Register of Social Enterprises - RUES (published on the website of ANOFM) and the Register of Authorized Protected Units (published on the website of the National Authority for the Protection of the Rights of Persons with Disabilities, Ministry of Labour and Social Solidarity).
The results underline the direct contribution of social economy organizations to SDG 1 (Poverty Free), SDG 3 (Health and Well-being), SDG 4 (Quality Education), SDG 8 (Decent Work and Growth), SDG 10 (Reducing Inequalities) and SDG 12 (Responsible Consumption and Production). By reporting on the SDGs, organizations clarify their social impact, improve transparency and accountability, and at the same time increase their attractiveness to donors and partners. This approach facilitates the creation of strategic partnerships and fundraising, contributing to sustainable and effective solutions. The SDGs also provide a clear framework for monitoring progress, assessing long-term impact and supporting public policies that promote sustainable economic and social development.
In conclusion, social economy organizations play a key role in transforming society and in achieving a significant number of Sustainable Development Goals, having a positive impact on communities, the environment and local economic development and are thus fundamental pillars of global sustainable development.
THE STATUS OF SOCIO-HUMAN DISCIPLINES IN PRE-UNIVERSITY EDUCATION. CASE STUDY IN ROMAN, ROMANIA
Authors: POENARU Alexandra-Georgiana
Published: February 2025

In this article, we present the results of an empirical study through which we analyzed the perception of teachers and students towards socio-human disciplines (with a case study in the municipality of Roman, Romania).  We were interested in the perceptions of teachers and students regarding the importance of socio-human disciplines specific to secondary and high school levels, by applying questionnaires to a sample of 110 teachers and 133 students. Comparatively, we wanted to know if there are significant differences between teachers' and students' opinions regarding the importance of socio-human subjects, to what extent there is the perception that the socio-human field is intended for students and less for students, as well as the differences in students' opinions according to their gender, class of studies, study path and environment of residence. This analysis were doubled by in-depth documentation on the school curricula, and the direct and indirect skills that students must acquire.
Energy Consumption and Economic Growth Nexus: Insights from EU Member States
Authors: ANDREI Dalina-Maria
Published: February 2025

The aim of this paper is to examine possible correlations between economic growth
and energy consumption in the European Union (EU27) member economies for the 1995-2021
interval. It searches for some short/long term relationships of these through a panel type model,
based on the Cobb-Douglas neoclassic production function. Reference examples in the literature
and tests applied for unit roots and cointegration determine our option for an autoregressive
distributed lag (ARDL) model able to identify both common coefficients of long-term relationship
between variables and individual (specific to each EU member country) coefficients on short-term
relationships. The per capita gross domestic product (GDP), as endogenous variable, is facing
three exogenous here chosen, that are: labor force participation rate (Labor); fixed capital
formation (GFCF) and the variable of interest primary per capita energy consumption (PEC). Our
results indicate a constant per capita GDP growth concomitant with the energy consumption
reduction - both these on aggregate in the EU region - thus suggesting a possible decoupling of
economic growth from energy consumption for recent years. But such a possibility wouldn’t
necessarily deny the existence of a long-term relationship between these two factors. These
results come to be completed by the ones of each individual EU member country, and so each
one of these will be found with its, existing or not, short- and long-term relationships between
the model variables.
Rethinking fairness of business and human rights standards in times of challenge for climate protection: a new universal paradigm?
Authors: GENTIMIR Alina , POPESCU Ada-Iuliana
Published: February 2025

Understanding the multivalent dimensions of the climate protection, including its ef-
fects on the rule of law, international and European intergovernmental organizations have de-
cided to act for rethinking the strategy of functioning business and human rights standards in
environmental protection general context. The article proposes solutions for such a strategy like
coherent macro and micro measures, transversality of action, synergy of normative, independ-
ence of control mechanisms, a closed collaboration established between intergovernmental
organizations, Governments and civil society. Would be necessary for human rights holders and
State and business enterprises obligations to satisfy exigencies of fairness? Would be taken into
consideration the double role of businesses related to activities that impact climate change in the
case of all the obligations imposed to business? Would be more efficient for States and, subse-
quently, for all business enterprises to implement “the smart mix of measures”? Using traditional
approach of 'black letter' methodology in order to collate, organize and describe legal rules, as
well qualitative and quantitative research methods for look to the impact of the law in practice
and the role played by public policy and a comparative historical approach for the human rights
analysis, the article emphasizes that despite recently lost battles in human rights and climate
protection, a general political will currently exists for creation and adoption of a new legal
frameworks which incorporates divers and stronger guarantees for a better protection of human
rights and environment.
A GIS-based model for multicriteria assessment of architectural cultural heritage conservation status
Authors: SPIRIDON-URSU Petronela , BREABĂN Iuliana-Gabriela , SANDU Ion , URSU Adrian
Published: February 2025

This paper aims to develop a model for assessing the conservation state of monuments
and cultural heritage sites, assisting local decision-makers in prioritizing conservation,
preservation, and management actions. The research focuses on religious monuments in the
Moldavian Plain from Romania using multi-criteria analyses to evaluate risks from natural factors,
socio-demographic elements, and economic development. The used methods aim to standardize
the level of natural and anthropogenic risk for religious cultural heritage in the counties of
Botoșani and Iasi through quantitative and qualitative approaches. For the digitization of
monument churches, data from the official list of historical monuments, topographic maps and
aerial photographs were combined. A tabular database was created, integrating various risk
indicators, with scores from 1 to 5, to obtain a total risk score for each monument. The study
integrates both natural and human geographical parameters into a Geographic Information
System (GIS) to create a pre-assessment risk model based on existing data. This model could
serve as a tool for decision-makers and specialists to identify the most vulnerable sites, optimize
expenses, and prioritize actions, ultimately saving time and resources.
This work was co-funded by the European Social Fund, through Operational Programme Human
Capital 2014-2020, project number OCU/993/6/13/153322, project title” Educational and
training support for Ph.D. students and young researchers in preparation for insertion into the
labor market”.