bluuebunny/crossref_metadata_2025 huggingface dataset:
Türkiye’de Lisanslı Depoculuk Sisteminin Tarım Piyasalarına Entegrasyonu ve Benimsenmesinin Önündeki Kısıtlar
Authors: Karabaş Selma
Published: May 2024

Bu çalışmanın amacı, tarım piyasalarının finansal piyasalarla buluşmasını ve ürün ihtisas borsacılığı ile türev piyasalara geçişini hızlandırmayı vadeden lisanslı depoculuk sisteminin, Türkiye’de beklenen başarıyı neden yakalayamadığını tespit etmektir. Bu amaçla çalışma, lisanslı depoculuk sisteminin tarım piyasalarına entegrasyonu ve üreticiler tarafından benimsenmesini engelleyen kısıtlara odaklanmıştır. Lisanslı depoculuk sisteminin üreticiye, sanayiciye, tüccara, tarımsal ve finansal piyasalara önemli avantajlar sunduğu literatürde birçok çalışmada yer almaktadır. Bu denli avantajlı bir sistemin benimsenmesini engelleyen unsurların belirlenmesi önemli görülmüştür. Yapılan araştırma ile, Türkiye’de lisanslı depoculuk sisteminin üreticide yeterince karşılık bulmamasının, gelişmekte olan diğer ülkelerde de aynı nedenlere bağlı olduğu tespit edilmiştir. Araştırma bulgularına göre, sistemin benimsenmesinde en önemli kısıt, lisanslı depo kapasitesinin yetersizliği, tarımın yapısal sorunları ve küçük ölçekli üreticiyi sisteme çekecek yeterli unsurun bulunmamasıdır. Türkiye ve gelişmekte olan çoğu ülkede tarımsal üretim, küçük çiftliklerde yapılmaktadır. Tarım sektörünün büyük çoğunluğunu oluşturan küçük aile çiftliklerinin sisteme katılımını sağlayacak politika ve motivasyon araçları geliştirilmediği sürece, sistemin amacına hizmet etmesi mümkün gözükmemektedir.
Karadeniz Bölgesinde Yaşayan Tüketicilerin Fındığa Yönelik Tutumlarının Belirlenmesi Üzerine Bir Araştırma
Authors: Öztürk Derya
Published: May 2024

Bu çalışmada, Karadeniz Bölgesinde yaşayan tüketicilerin fındığa yönelik tutumlarının belirlenmesi amaçlanmıştır. Araştırmada ayrıca, katılımcıların fındığa yönelik tutumlarının demografik özelliklerine göre farklılık gösterip göstermediği de tespit edilmeye çalışılmıştır. Araştırmanın evrenini Karadeniz Bölgesinde yaşayan 18-65 yaş arasındaki kişiler oluşturmaktadır. Örneklemini ise kolayda örnekleme yöntemi ile seçilen ve gönüllü olarak araştırmaya katılan 384 kişi oluşturmaktadır. Verilerin analizinde tanımlayıcı istatistiksel analizler, açımlayıcı faktör analizi, t-testi ve Anova testleri kullanılmıştır. Araştırma bölgesindeki tüketicilerin çoğunluğunun fındığı genellikle haftada 2-3 kez olmak üzere yarım avuç kadar natürel iç fındık şeklinde akşam öğünlerinde tükettikleri görülmüştür. Tüketicilerin fındığa yönelik tutumlarını ölçmek amacıyla yapılan faktör analizi sonucunda sağlık, kültür, mutluluk ve lezzet olmak üzere dört alt boyut elde edilmiştir. Fındığa yönelik tutum ölçeğinin lezzet alt boyutu hariç diğer bütün alt boyut ortalamalarının tüketicilerin bazı demografik özelliklerine göre farklılaştığı tespit edilmiştir. Bekar ve erkek tüketicilerin evli ve kadın tüketicilere oranla fındığa yönelik tutumlarında mutluluk alt boyutunun daha önemli olduğu görülmüştür. Tüketicilerin yaş ve eğitim düzeyi arttıkça fındığa yönelik tutumlarında sağlık alt boyutunun daha önemli olduğu sonucuna ulaşılmıştır. Bu çalışma sonucunda elde edilen bulguların; fındık tüketicilerinin yaşam standartlarını sağlıklı yaşam ve psikolojik olarak mutluluk ekseninde ele alarak insanlara yol göstermesi açısından faydalı olacağı düşünülmektedir.
Siyez, Dinkel ve Kavılca Unu ile Kaplanmış Tavuk Nuggetların Soğukta Depolama Süresince Bazı Kalite Özelliklerinin İncelenmesi
Authors: Fadıloğlu Eylem Ezgi , Ergezer Haluk , Demiray Engin
Published: May 2024

Bu çalışmanın amacı, Siyez, Kavılca ve Dinkel gibi atalık buğday unlarının tam buğday unu yerine kaplama formülasyonlarında kullanılmasının tavuk nuggetların kalitesi üzerine etkilerini araştırmaktır. 4°C’de 7 gün depolanan derin yağda kızartılmış tavuk nuggetların kimyasal özellikleri, kalite karakteristikleri, pH, lipid oksidasyonu, renk, doku ve duyusal özellikleri değerlendirilmiştir. Hamur formülasyonları, nuggetların kimyasal ve kalite özelliklerini önemli ölçüde etkilediği, Dinkel unu ile kaplanan tavuk nuggetlarda kaplama kalınlığının, kaplama yapışma oranının ve pişirme veriminin en yüksek olduğu tespit edilmiştir. Kontrol örneklerinin renk puanlarının depolama süresi boyunca azaldığı, atalık unlarla kaplanmış tavuk nuggetların renk puanlarının değişmediği tespit edilmiştir. 0. günde Siyez unu ile kaplı örnekler en yüksek lezzet puanını alırken, 3. günde örneklerin lezzet puanlarının birbirine yakın olduğu tespit edilmiştir. Depolamanın 7. gününde kontrol örneği en düşük lezzet puanını almıştır. Siyez unu ile kaplanmış tavuk nuggetların sululuk puanlarının depolama süresince değişmediği, doku puanlarının arttığı tespit edilmiştir. Siyez ve Kavılca unu ile kaplanmış nuggetların genel kabul edilebilirlik puanları depolamanın 0. ve 3. günlerinde kontrol örnekleriyle benzer bulunmuştur. Doku profil analizinde, tüm nuggetlarin sertlik, yapışkanlık, elastikiyet ve sakızımsılık değerleri arasında anlamlı bir farklılık olmadığı belirlenmiştir. Depolama süresi arttıkça Kavılca unu ile kaplı örneklerin sertlik değerinin arttığı, çiğnenebilirlik değerlerinin azaldığı tespit edilmiştir.
Hyaline fibromatosis syndrome: a rare, yet recognizable syndrome
Authors: Daşar Tuğba , Gönen Hasibe Nesligül , Kösemehmetoğlu Kemal , Tekşam Özlem , Boduroğlu Koray , Utine Gülen Eda , Şimşek Kiper Pelin Özlem
Published: May 2024

Background. Hyaline fibromatosis syndrome is a rare autosomal recessive disorder caused by ANTXR2 pathogenic variants. The disorder is characterized by the deposition of amorphous hyaline material in connective tissues. The hallmarks of the disease are joint contractures, generalized skin stiffness, hyperpigmented papules over extensor surfaces of joints, fleshy perianal masses, severe diarrhea, and gingival hypertrophy. The severity of the disease varies and prognosis is poor. No specific treatment is yet available. Most patients with the severe form of the condition pass away before the second year of age. In this study, we describe the clinical and molecular findings of a cohort of seven hyaline fibromatosis syndrome patients who were diagnosed and followed up at a single tertiary reference center in Turkey.
Methods. Genomic DNA was extracted by standard salting out method from peripheric blood samples of three patients. In one patient DNA extraction was performed on pathology slides since peripheric blood DNA was not available. All coding exons of the ANTXR2 were amplified and sequenced on ABI Prism 3500 Genetic Analyser.
Results. Sanger sequencing was performed in 3 patients and homozygous c.945T>G p.(Cys315Trp), c.1073dup p.(Ala359CysfsTer13), and c.1074del p.(Ala359HisfsTer50) variants were identified in ANTXR2. All patients passed away before the age of five years.
Conclusions. HFS is a rare, progressive disorder with a broad phenotypic spectrum. HFS can be recognized easily with distinctive clinical features. Nevertheless, it has poor prognosis with increased mortality due to severe clinical decompensation.
Exercise capacity and muscle strength in patients who have undergone the Fontan procedure: a retrospective follow-up study
Authors: Tekerlek Haluk , Sağlam Melda , Selçuk Sinem Nur , Aykan Hayrettin Hakan , Vardar Yağlı Naciye , Çalık Kütükcü Ebru , İnal İnce Deniz , Karagöz Tevfik
Published: May 2024

Background. Due to their relationship with clinical progression, follow-up of exercise capacity and muscle strength is important for optimal disease management in patients who have undergone the Fontan procedure. We aimed to retrospectively analyze exercise capacity and muscle strength trajectory over approximately 2 years.
Methods. Exercise capacity was assessed using an exercise stress test with the modified Bruce protocol on a treadmill, hand grip and knee extensor strength using a hand dynamometer, and body composition using a bioelectrical impedance device. Exercise capacity, muscle strength, and body composition follow-up data recorded between 2020 and 2022 were compared.
Results. Fifteen patients [median age from 17 (first assessment) to 18 years (last assessment), 5 females)] with a 20-month median follow-up time were analyzed retrospectively. There was an increase in weight, height, body mass index, and body fat weight (p<0.05). There was a tendency for increased handgrip strength (%) (p=0.069), but no significant difference was observed in the knee extensor strength of patients during the follow-up period (p>0.05). The changes in heart rate (HR) and oxygen saturation were higher in the last test than in the first test (p<0.05). Maximum HR (HRmax), % predicted HRmax and HR reserve recorded during the test and HR 1 minute after the test were similar between the first and last tests (p>0.05).
Conclusions. After 20 months of follow-up, exercise capacity and muscle strength did not decline; instead, the body mass index and fat weight increased. Patients who have undergone the Fontan procedure may not be experiencing a decline in exercise capacity and muscle strength over relatively short time periods during childhood, adolescence, and early adulthood.
‘You Have To Respect The Water’: Participant Experiences of Appreciating and Managing the Risks Associated with Open Water Swimming – A Rapid Ethnographic Study
Authors: Christie Mark , Elliott David
Published: May 2024

Open water swimming (OWS) has rapidly grown in popularity, driven by the purported health benefits of cold-water immersion. A paucity of research remains specifically considering the notable risks inherent in OWS participation, and a lack of qualitative research on freshwater swimming experiences, and safety-related issues therein. This rapid ethnographic study, based at a dedicated OWS lake in the UK, conducted semi-structured interviews with OWS participants (n=17; female=11, male=6). Two core themes emerged: environmental issues impacting OWS experiences and behaviours; and knowledge and education of OWS which highlighted safe/unsafe practices, levels of education for managing risks, personal preparedness, swimming solo/with others, use/non-use of specialised equipment, anxieties relating to participation, and environmental conditions. Findings suggest a lack of safe practice persists pertaining to immersion in cold water environments. Specific strategies are suggested that organisations involved with the promotion of the sport should consider to promote safer and more enjoyable OWS experiences.
Exploring school counselor-principal collaboration, self-efficacy, and school climate: A comprehensive review of literature
Authors: Geesa Rachel Louise , Kunce Derien , Hunt Audrey
Published: May 2024

School counselors and principals have many shared responsibilities within PK-12 schools to better meet students’ social/emotional, academic, and career and college readiness needs. School counselor-principal collaboration can promote the success of PK-12 students, staff, and the overall school environment. Within the area of school counselor-principal collaboration, more research is needed regarding the implementation of collaboration methods between the two professions at pre-service levels. Due to this need, we conducted an extensive literature review to examine the developments and outcomes of school counselor-principal collaboration. Based on the review of 33 articles, the following themes emerged within the literature. These themes focus on increased individual and group self-efficacy of school counselors and administrators, the importance of school counselor-principal collaboration at the pre-service level, the assignment of non-counseling duties resulting in school counselor burnout, the need for self-advocacy of school counselors, and the relationship of positive school climate and school counselor-principal collaboration.
Qualitative and quantitative metabolomics of Pamburus missionis Swingle – a medicinal tree taxon
Authors: Yaswanthi M. Sai , Pallavi P. N. , Savithramma N.
Published: May 2024

Since ancient times, Plant based medicine is a well-known oldest form of healthcare to mankind. Even the commercial medications used for the treatment of various ailments today, contains a large proportion of plant derived chemical compounds. Hence chemical profiling of medicinal plants gained a key role to use them in pharmaceuticals as well as commercial industries. Pamburus missionis is one of the medicinal plants used in the Indian and Srilankan traditional medicine system to reduce kapha dosha. The ayurvedic physicians used its leaves to treat swelling, piles, fractures, fistula, puerperal diseases and as serpent venom. Therefore, the present study was undertaken to reveal the phytocompounds from various parts of this plant. Metabolomics revealed the presence of primary and secondary metabolites like carbohydrates, lipids, proteins, alkaloids, phenols, flavonoids, steroids etc. From the aqueous extract, Alkaloid content is almost same in leaf, stem and bark extracts with around 1.2 to 1.3 g (w/v%) and completely absent in the fruit. Phenolic content and steroids are notably high in leaf extract with 112.77±0.34 mg/g of extract and 17.91±0.26 mg respectively, where the flavonoid content in fruit extract with 44.69±0.30 mg/g of extract and the tannin content in bark extract with 62.37±1.75 mg/g of extract.
Morphological and pathogenic characterization of Fusarium species causing common bean root rot in Uganda
Authors: Erima Samuel , Nyine Moses , Edema Richard , Nkuboye Allan , Nakibuule Justine , Paparu Pamela
Published: May 2024

Fusarium root rot (FRR) of common bean occurs in Africa, Central and South America, and causes yield losses of up to 86%. Recently, FRR-like wilt symptoms were observed in Uganda’s agroecology zones. To identify the causal pathogen, we conducted surveys in seven agroecology zones to determine the prevalence and incidence of the reported disease. During the surveys, diseased roots were collected for pathogen isolation.  Fungal strains were characterized using colony color, mycelial growth rate and microscopic structures such as conidia and microconidia. The pathogenicity of 99 strains on five bean varieties was determined in artificially inoculated soils in the screenhouse. Based on field symptoms, the observed wilting was identified to be Fusarium root rot, the prevalence of which varied across agroecologies, with the highest (95%) in the Karamoja pastoral zone (KP) and the lowest (40%) in West Nile farming system (WN). Similarly, the incidence of FRR was highest (87%) in KP, and lowest (20%) in WN. Fusarium strains differed in growth rate, colony color, shape and size of microscopic structures. All evaluated strains were pathogenic on common bean and caused severities of 0.9 to 98.3%. Further studies are required to identify the isolated strains at the species level using molecular tools.
Physicochemical, cooking and sensory properties of Mackerel fish burger fortified with globe artichoke Cynara scolymus L.
Authors:   Department of Food Technology, Faculty of Agriculture, Kafrelsheikh University, Egypt, ELMESHAD WALAA , ABDELGALEEL MOHAMMED ,   Department of Food Technology, Faculty of Agriculture, Kafrelsheikh University, Egypt, BORIY ESMAIL ,   Food Sciences and Technology Department, Faculty of Agriculture, Damanhur University, Egypt, BADAWY W.Z. ,   Department of Food Technology, Faculty of Agriculture, Kafrelsheikh University, Egypt, ALI MOSTAFA ,   Department of Food Technology, Faculty of Agriculture, Kafrelsheikh University, Egypt
Published: May 2024

The present study aims to characterize the globe artichoke parts, receptacle (AR) and bracts (AB), and to evaluate the quality characteristics of fish burger formulated by partial substitution of Mackerel fish meat with different level of both AR and AB. Physicochemical, cooking measurements and sensory characteristics of fish burgers were analyzed. The study results showed that the used artichoke parts had high protein, crude fiber, inulin and ascorbic acid contents. Total phenolics content of AR and AB was 43.1 and 38.2 (mg galic acid equivalent/g), respectively. The addition of artichoke parts to fish burger showed improvement in the cooking properties for instance increase cooking yield and decrease cooking loss and shrinkage, without noteworthy differences in sensory properties. Moreover, it was concluded that artichoke parts could be a great source of health-promoting phenolic compounds with high antioxidant activity. Therefore, our results could promote the consumption of artichoke parts and their using in di􀵵 erent industrial food applications.
Transacción del cuerpo como mercancía en Hasta ya no ir de Beatriz García Huidobro
Authors: Bianchi Paula Daniela
Published: May 2024

En Hasta ya no ir de la escritora chilena Beatriz García Huidobro se trabajarán las diversas estrategias de resistencia y transgresión esgrimidas por la protagonista que lleva a cabo para sobrevivir la hostilidad de aquello que se percibe como peligroso. Es decir, cómo a partir de la reactivación y transacción de su propio cuerpo como mercancía constituye su identidad, construye nuevos espacios indeterminados donde circulan otros cuerpos y articula la ambigüedad de las configuraciones femeninas.
Historia de un entusiasmo: una invitación a la escritura
Authors: Valencia Ortiz Ida
Published: May 2024

La obra Historia de un entusiasmo, escrita por Laura Restrepo es el motivo del siguiente artículo donde la autora explora las perspectivas de lectura que abre esta narración, cautivante y convulsionada por dedicarse a revisar el periodo presidencial de Belisario Betancurt (1982-1986), y su fallido proceso de paz. Se parte del cuestionamiento que hace la autora de las dinámicas de poder desde las altas esferas, hasta la cotidianidad y el drama íntimo de sus personajes
Transformaciones de la Identidad y Pasiones Humanas
Authors: Gómez Goyeneche Maria Antonieta
Published: May 2024

Se plantea en este artículo una inquietud teórica respecto a una corriente de las metamorfosis, motivada bajo efectos de las pasiones humanas y sus repercusiones para con la construcción identitaria de personajes de índole ficcional. A través de las ilustraciones seleccionadas en la mitología grecorromana y su recreación literaria en Ovidio, así como en algunos cuentos de hadas, se explora en su motivación algunos paralelos e implicaciones culturales que corresponden a esta posibilidad creativa.
UM ESTUDO SOBRE DISCIPULADO ATRAVÉS DO CULTO FAMILIAR E SUA IMPORTÂNCIA PARA MISSÃO.
Authors: Gabriel Marques da Silva Eder , Rodrigues dos Santos Manoel
Published: May 2024

Introdução: A família é o nosso primeiro e principal ciclo social durante as fases da vida. Através dela somos influenciados, alicerçamos nossa cosmovisão e recebemos as primeiras bases de nossas crenças e princípios. Mas para que o desenvolvimento desses elementos seja possível, faz-se necessário acompanhamento, instrução e uma série de cuidados que englobam o processo de discipulado. Através do culto familiar, pais e filhos se reúnem em um momento de comunhão com Deus e com a família, proporcionando um encontro diário que pode ser oportuno para exercer o discipulado. Este trabalho visa apresentar como o discipulado através do culto familiar tem sua importância para a missão.
Objetivo: Analisar o discipulado através do culto familiar e sua importância para a missão.
Método: Faz-se necessária a utilização do método de abordagem dedutiva de pesquisa qualitativa que buscará medir a importância do discipulado para o cumprimento da missão a partir do papel desenvolvido pela família, conforme fundamentos nos argumentos de Rossman e Rallis (CRESWELL, 2007, p. 184). Porém, também apresentará suas fundamentações através de pesquisa bibliográfica, porque analisará o que os pesquisadores e estudiosos declaram sobre o discipulado no culto familiar.
Resultados esperados: Espera-se a partir da pesquisa supracitada, identificar o processo de discipulado nos lares resultante do culto familiar, concomitantemente, medir sua importância para o cumprimento da missão a partir do papel desenvolvido pela família.
Descritores: Discipulado, culto familiar, missão.
The icon of Ukrainian Nazis: on the question of the historical assessment of the «heroes» under the Protection of the Virgin Mary and their modern admirers
Authors:   Omsk State Technical University, Sushko A. V.
Published: May 2024

The study is based on a source analysis (external criticism) of a modern icon of Ukrainian nationalists, on which, under the Protection of the Virgin Mary, among other historical figures, Greek Catholic metropolitans Andrei Sheptytsky and Joseph Slipyi are depicted, as well as the leaders of the OUN-UPA (organizations recognized as extremist in Russia and banned) Stepan Bandera and Roman Shukhevych. A historical assessment of the activities and the presence of these figures who collaborated with the German Nazis on the icon is given. The main emphasis is on the interaction of the depicted «heroes» with the NSDAP, SS, SD and Gestapo, found guilty of crimes against humanity by the International Military Tribunal. In addition to the image itself, which became the reason for writing this article, the source for the study is the forensic investigative documentation of the Soviet state security agencies, during and after the end of the Great Patriotic War, interrogating captured employees of the German special services, Ukrainian nationalists and witnesses to their war crimes. The presence of specific common features in the biographies depicted on the icon of Nazi criminals has been established. The author emphasizes that people who publicly glorify Ukrainian nationalists through an icon are subject to Article 4 of the International Convention on the Elimination of All Forms of Racial Discrimination, which requires states parties to the Convention to prosecute them.
Keeping the memory of Napoleonic wars: forms of international cooperation between Russia and the German Empire at the beginning of the twentieth century
Authors:   Dostoevsky Omsk State University, Lizogub A. S.
Published: May 2024

The article is devoted to the characteristics of the main forms of international cooperation used at the beginning of the twentieth century keeping the memory of significant events in military history. Based on archival documents, press materials and personal testimonies, the preparation, semantic content and attitude of society towards Russia’s participation in commemorative projects implemented on the territory of the German Empire on the eve of the First World War are analyzed. The focus is on considering the features and problems of building narratives about the joint military past of the two empires within the framework of the international exhibition in Breslau and the opening of monuments in Leipzig. The author concluded that the implementation of commemorative projects dedicated to the 100th anniversary of the victory in the Napoleonic wars is influenced by the existing system of international relations. Behind the scenes of the grandiose celebrations was hidden the desire of the German Empire to provide a historical justification for its foreign policy course. For the Russian state, participation in joint projects provided an opportunity to remind Europe of its role in the international arena and the strength of the army. Promising directions for further research of the problem are outlined.
Treatment modalities for management of skeletal and dental Class III malocclusion – A case series
Authors: Panda Sukanya , Remin N. M. , Biswal Soumyashree , Tandon Ragni
Published: May 2024

Class III malocclusion is a challenging phenomenon to comprehend. Research done to determine the cause of Class III malocclusion revealed that the deformity affects all aspects of the craniofacial system, not only the jaws. Skeletal and dentoalveolar abnormalities coexist in the majority of patients with Class III malocclusion. Orthognathic surgery, dentoalveolar compensation, and growth modification are the three main therapies available for skeletal Class III malocclusion. Until the pubertal growth spurt, growth modification needs to be started. Thereby, in order to deal with skeletal Class III malocclusion in a grownup, orthognathic surgery collectively with conventional orthodontic therapy will be required in order optimize facial esthetics as well as attain stable occlusion. The objectives of the case series are to highlight different approaches to resolving skeletal Class III malocclusion, which includes orthognathic surgery, orthopedic appliance therapy, and extractions.
Efficiency of friction versus frictionless mechanics for correcting bimaxillary dentoalveolar protrusion in dizygotic twins – A case report
Authors: Aziz Rezeen , Goutham B. , Somaiah Sanju , Muddaiah Sunil
Published: May 2024

The purpose of this case presentation is to determine the efficiency of two treatment mechanics in correcting clinically comparable malocclusion in dizygotic twins. The case report describes the orthodontic management of 19-year-old non-identical twins diagnosed with bimaxillary dentoalveolar protrusion on a Class I skeletal base with severe crowding using two different treatment mechanics. The first patient was treated with frictionless mechanics by making use of Kalra simultaneous intrusion and retraction arch for space closure, whereas the friction mechanics accomplished the task in the second patient with mini-implant (Titanium mini-implant, FavAnchor™ SAS, Favorite supplies, Thane west, Maharashtra, India) assisted power arm (Power hook, Azdent Orthodontics, Zhengzhou, China) retraction. It evaluated the overall treatment duration, anterior torque control, and level of comfort for the patients with the two mechanics. The post-treatment results in both cases exhibited remarkable change in inclination of upper anterior teeth which were established through cephalometric findings. Moreover, the anterior torque control was comparatively superior with loop mechanics over mini-implant assisted sliding mechanics. Both the treatment mechanics effectively and efficiently corrected the malocclusion with considerable impact on soft-tissue profile.
Blue sclera syndrome (Lobstein – Van der Hoeve)
Authors:   Ufa Eye Research Institute, Ufa, Russian Federation, Babushkin A.E. , Israfilova G.Z. ,   Ufa Eye Research Institute, Ufa, Russian Federation, Saitova G.R. ,   Ufa Eye Research Institute, Ufa, Russian Federation
Published: May 2024

The article presents a literature review and a case presentation of the rare and often hereditary condition «blue sclera», which is also called Lobstein – Van der Hoeve syndrome. As is known, the triad of this syndrome – blue sclera, bone pathologies and hearing impairment – is manifested in infancy. Despite its typical clinical signs, difficulty with diagnosis can cause incomplete and late clinical manifestation, in particular in adult patients. The authors emphasize associations of glaucoma process and the syndrome and confirm the fact of refractory glaucoma in blue sclera syndrome, which required maximum hypotensive therapy and subsequent radical knife surgery. Unfortunately, to date there is no effective treatment for many disabling genetic conditions, including the blue sclera syndrome and osteogenesis imperfecta. Treatment strategies for the blue sclera remain symptomatic and present real challenges; given the known and severe concomitant changes in the skeleton system and hearing, require interdisciplinary approach. There is hope that advancements obtained at the course of clinical trials will contribute to improving the treatment of these conditions. Key words: blue sclera syndrome, osteogenesis imperfecta, glaucoma, refractory to treatment, interdisciplinary approach to treatment
Personnel Selection Based on the LBWA, TOPSIS and GRA Methods: A Case Study on Foreign Trade Company
Authors: Özekenci Emre Kadir
Published: May 2024

Recruitment and personnel selection are affected by significant factors. Thus, personnel selection is one of the main decision-making problems for a company’s long-term survival. The objective of this study is to identify the most suitable candidate for the export department of a company operating in Mersin, using the Level Based Weight Assessment (LBWA)-based Technique of Order Preference Similarity to the Ideal Solution (TOPSIS) and Grey Relational Analysis (GRA) methods. The criteria were determined based on the literature review and experts’ opinions. The weight of criteria was calculated by the LBWA method, and the alternatives (candidates) were ranked using the TOPSIS and GRA methods. The LBWA results showed that fluency in a foreign language and team player were the most and least important criteria, respectively. The results from both methods (TOPSIS and GRA) suggested different candidates for the relevant positions. Furthermore, sensitivity analyses were conducted to assess the validity and robustness of the results. In conclusion, the findings of this study provide valuable insights to decision-makers involved in the personnel selection process.
Türkiye’de Hayvanların Korunması Politikası
Authors: Çankaya Hürol , Ekiz Cengiz , Şahin Nur
Published: May 2024

Hayvanların korunması ile ilgili literatürü incelediğimizde Türkiye’de bu alandaki tartışmaların kökeninin 19. yüzyıla uzandığı görülmektedir. Modernleşme süreci, hayvanların korunması sürecini kırılganlaştırmaya başlamış ve dönemin kamu otoritesi, nefret dili kullanarak hayvanlara yönelik şiddetin meşrulaştırılmasına neden olmuştur. 1980’li yıllardan itibaren etkisiz yasal düzenlemeler ile sorun derinleşmiş ve 2004 yılında 5199 sayılı Hayvanları Koruma Kanununun yürürlüğe girmesiyle de bu süreç yeni bir evreye girmiştir.
Türkiye’de hayvanlara yönelik geliştirilen kamu politikaları hak ekseninden uzaktır. Türkiye’deki mevzuat, hayvanları “eşya” ya da “meta” kategorisi üzerinden tanımlamaktadır. Hayvan hakları konusunda kamu otoritesi, düzenleme ve karar düzeyinde hiçbir politika inşa etmemiştir. Üstelik, kurumsal yapıdaki yetki ve görev karmaşası, hayvanların korunması sürecini doğrudan etkilemektedir. Türkiye’de hayvanların korunmasına ilişkin yasal tedbirlerin etkisizliği hem merkezi yönetimin hem de yerel yönetimlerin teşkilat yapısına da yansımıştır. Bu yapının yerel düzeydeki koordinasyonunu İl Hayvanları Koruma Kurulu yürütmektedir. Kurulun yetki ve işlevindeki dağınıklık, hayvan hakları konusunda somut düzenlemelerin yapılmasını ve tedbirlerin alınmasını zorlaştırmaktadır.
Çalışma üç bölümden oluşmaktadır. İlk kısım, hayvan haklarının Osmanlı ve Cumhuriyet dönemlerini kapsayan yüz yıllık tarihçesini içermektedir. İkinci kısım, Türkiye’de hayvan hakları politikasının çerçevesini kapsamaktadır. Üçüncü kısım ise yasal işleyişin dayanaklarını oluşturan idari ve hukuksal yapıyı tartışmaktadır.
LCC Hipotezi Çerçevesinde Çevresel Kalite ve Kentleşme Arasındaki İlişki: Türkiye’den Ampirik Kanıtlar
Authors: Çamkaya Serhat
Published: May 2024

Yük kapasitesi faktörü, son zamanlarda geliştirilen ve doğanın sadece tüketim tarafını değil, aynı zamanda arz tarafını dikkate alan son derece kapsamlı bir çevresel kalite göstergesidir. Bu yüzden son dönem çalışmalara bakıldığında yük kapasitesi faktörünün çevresel kalite göstergesi olarak kullanıldığı görülmektedir. Bu bağlamda çalışma, önceki literatürden farklı olarak Türkiye’de yük kapasitesi eğrisi (LCC) hipotezi çerçevesinde yük kapasitesi faktörü üzerinde ekonomik büyümenin ve kentleşmenin uzun dönemli etkisini test etmeyi amaçlamaktadır. Söz konusu etkinin testi için 1961-2022 dönemi arasındaki yıllık veriler ve Fourier temelli zaman serisi teknikleri (ADF, ADL ve FMOLS) kullanılmıştır. Ayrıca, çalışmanın uzun dönem sağlamlık sınaması yine Fourier temelli DOLS ve kesirli frekanslı esnek Fourier Toda-Yamamoto (FFFF-TY) nedensellik teknikleriyle sınanmıştır. Çalışmadan elde edilen ampirik bulgular, Türkiye’de LCC hipotezinin geçerli olduğunu fakat Türkiye’deki gelirin çevresel kaliteyi iyileştirebilecek seviyede olmadığını göstermektedir. Ayrıca, bulgular artan kentleşmenin yük kapasitesi faktörünü azaltarak çevresel kaliteyi bozduğunu ortaya koymaktadır. Ampirik bulgulardan hareketle, Türkiye’deki politika yapıcılar çevresel kalitenin arttırılması için bazı politikaları ivedilikle hayata geçirmelidir. Bunun için politika yapıcılar, daha fazla yenilenebilir enerji kaynaklarına yatırım yapacak adımları atmalıdır. Ayrıca, yeşil büyümenin tesisi için de gerekli adımlar atılmalıdır. Son olarak, sürdürülebilir kentleşmenin tesisi için ortak paydaşlarla kapsamlı çevresel stratejiler oluşturulmalı ve uygulamaya konmalıdır.
Analyzing Türkiye’s Import Dependency of Exports: A Sectoral Approach
Authors: Varlık Serdar , Sevgi Nurhan Hande , Berument Hakan
Published: May 2024

The high import dependency of exports is an important cause of external vulnerability for economies pursuing an export-led growth strategy. The purpose of this paper is to analyze the import dependency of exports in Türkiye, which adopts the export-led growth model, and to identify the sectors that will contribute to reducing the import dependency of exports. This study investigates Türkye’s time-varying import dependency of exports from January 2013 to January 2024 using ISIC Rev.4 classification and state space model. The findings reveal that while the import dependency of exports was on a downward trend from early 2013 until September 2019, this trend reversed after this date and the import dependency of exports started to increase rapidly. A one percentage increase in the deviation of exports from their potential increases the import dependency of exports by 0.65% on average. The highest import dependence of exports is observed in the Manufacturing sector. When examining manufacturing sub-sectors, Textile, Wearing Apparel and Basic Metals show the highest dependency increase, while Beverages, Tobacco Products and Printing & Reproduction of Recorded Media sub-sectors exhibit the lowest. From this point of view, in order to reduce the import dependency of exports, policies such as increasing export potential, reducing deviations from potential and encouraging vertical integration with the domestic industrial structure, as well as providing tax advantages to encourage the use of domestic intermediate goods especially in sectors with high import dependency can be recommended. Furthermore, technological innovations that allow using domestically produced intermediate goods and capital goods also may create permanent effects on decreasing import dependency.
Synthesis of Cs3Cu2I5 Nanocrystals in a Continuous Flow System
Authors: Arslanova Ksenija , Ganswindt Patrick , Lorenzen Tizian , Kostyurina Ekaterina , Karghiosoff Konstantin , Nickel Bert , Müller-Caspary Knut , Urban Alexander S.
Published: May 2024

Achieving the goal of generating all of the world’s energy via renewable sources and significantly reducing our energy usage will require the development of novel abundant, nontoxic energy conversion materials. Here, we develop a cost-efficient and scalable continuous flow synthesis of Cs3Cu2I5 nanocrystals as a basis for the rapid advancement of novel nanomaterials. Ideal precursor solutions were obtained through a novel batch synthesis, whose product served as a benchmark for the subsequent flow synthesis. Realizing this setup enabled a reproducible fabrication of Cs3Cu2I5 nanocrystals. We determined the effect of volumetric flow rate and temperature on the final product’s morphology and optical properties, obtaining 21% quantum yield with the optimal configuration. Consequently, we can tune the size and morphology of the nanocrystals with far more precision and in a much wider range than previously achievable. The flow setup is easily applicable to other relevant nanomaterials. It should enable a rapid determination of a material’s potential and subsequently optimize its desired properties for renewable energy generation or efficient optoelectronics.
Synthesis and Application of Robust Spiro [Fluorene 9] CAAC Ruthenium Alkylidene Complexes to the „One-Pot“ Conversion of Allyl Acetate to Butane-1,4-diol
Authors: Erdélyi Ádám , Farkas Vajk , Turczel Gábor , Nagyházi Márton , Bényei Attila , Ledesma Recta Merell Lystra , Nagy Tibor , Kéki Sándor , Osterthun Ole , Klankermayer Jürgen , Tuba Róbert
Published: May 2024

A series of a novel CAAC ligands featuring a spiro-fluorene group have been synthesized and complexed with ruthenium alkylidenes, yielding the corresponding Hoveyda-type derivatives as a new family of olefin metathesis catalysts. The novel complexes have been characterized by XRD, HRMS and NMR measurements. The synthetized complexes were tested in catalysis and showed good activity in olefin metathesis, as demonstrated on diethyl diallylmalonate and allyl acetate substrates. The unique backbone in the ligand system with the large, yet inflexible condensed system renders interesting properties to the catalyst, exemplified by the good catalytic performance and improved Z selectivity. In addition, the catalyst can also serve as a hydrogenation catalyst in a consecutive (one-pot) reaction. The latter reaction can convert allyl acetate to butane 1,4 diol, a valuable chemical intermediate for biodegradable polybutylene succinate (PBS).
ZAGREB CONNECTION INDICES ON POLYOMINO CHAINS AND RANDOM POLYOMINO CHAINS
Authors: Sigarreta Ricardo Sayle , Cruz Suárez Hugo Adán
Published: May 2024

In this manuscript, we delve into the exploration of the first and second Zagreb connection indices of both polyomino chains and random polyomino chains. Our methodology relies on the utilization of Markov chain theory. Within this framework, the article thoroughly examines precise formulas and investigates extreme values. Leveraging the derived formulas, we further explore and elucidate the long-term behavior exhibited by random polyomino chains.
Flux decline prediction in dead-end ultrafiltration combining fluorescence spectroscopy and mechanism-informed machine learning
Authors: Tagliavini Matteo , Snyder Shane Allen
Published: May 2024

Membrane fouling, which leads to water flux decline with time, is the greatest challenge in membrane filtration. The complexity of phenomena itself, as well as the heterogeneous and fluctuating characteristics of dissolved organic matter, make fouling prediction an arduous task. In this work, a novel approach to predict fouling and flux decline under fluctuating organic load is proposed, developed and validated. A semi-empirical mechanistic model (Hermia) is empowered with support vector machine to address the mechanistic complexity of fouling phenomena. The inputs of the machine learning steps are the initial flux, the organic load, and the excitation-emission fluorescence spectra. The model was trained varying initial flux, organic carbon load and composition. Model validation on unknown experiments (e.g., experiments the model was not trained on) revealed a good predictive accuracy, with R2 ranging from 0.87 to 0.99, with an average of 0.95. The proposed approach is expected to have great potential in the field of membrane processes and water technologies in general.
Polypharmacological Modulation of Atrial Fibrillation: Rational Design, Synthesis, and Evaluation of Novel Compounds Targeting NaV1.5, KV1.5, and K2P Channels
Authors: Camargo-Ayala Lorena , Bedoya Mauricio , Dasí Albert , Prüser Merten , Prent-Peñaloza Luis , Adasme-Carreño Francisco , Kiper Aytug , Rinné Susanne , Camargo-Ayala Paola Andrea , Peña-Martínez Paula Andrea , Bueno-Orovio Alfonso , Varela Diego , Wiedmann Felix , Márquez-Montesinos José Carlos Estanislao , Schmidt Constanze , Rodriguez Blanca , Ravens Ursula , Decher Niels , Gutiérrez Margarita , González Wendy
Published: May 2024

During atrial fibrillation (AF), electrical remodeling occurs, involving ion channels like NaV1.5, KV1.5, and TASK-1. A promising AF treatment encompasses inhibiting these channels. In this study, acetamide compounds were designed based on the local anesthetic pharmacophore as potential NaV1.5, KV1.5, and TASK-1 inhibitors. Compound 6f emerged as the most potent in the series, with IC50 values determined in Xenopus oocytes of approximately 0.3 µM in TASK-1, 81.5 µM in KV1.5, and 21.2 µM in NaV1.5. Unexpectedly, 6f activated at 100 µM another cardiac K2P channel (TASK-4) by about 40%. Next, we performed patch clamp experiments of human atrial cardiomyocytes from sinus rhythm (SR) or AF patients. In SR 6f reduced action potential amplitude (indicating NaV1.5 block) while in AF it increased action potential duration (APD), reflecting high affinity for TASK-1. Additionally, a hyperpolarization in resting membrane potential occurred in AF cardiomyocytes by 6f, consistent with the TASK-4 activation we observed. In a mathematical whole-atria model, 6f prolonged APD and tissue refractoriness, proving efficacious both for AF prevention and cardioversion. Favorable pharmacokinetic properties of 6f in silico, including good absorption and low toxicity, as well as its lack of cytotoxicity in a hemolytic assay, suggest its potential as an AF treatment.
La novela biográfica y la reescritura histórica desde los márgenes. Apuntes en torno a Maestra Vida de Guillermo Thorndike
Authors: Pek Bardales Pereyra Gregory , Vallejos Rodríguez Zulema
Published: May 2024

Cuando la historia es contada desde la perspectiva de actores distintos, se alteran las versiones generalmente aceptadas de los hechos, y el resultado de los acontecimientos, así como también la imagen que guardamos de nuestros más caros personajes históricos, sus actitudes y motivaciones. Novelas como Maestra Vida nos permiten conocer y reconstruir un pasado histórico pétreo, aparentemente inamovible, recuperar los silencios de la historia y presentar el pasado desde una perspectiva diferente.
José Agustín de la Puente Candamo en los inicios del Opus Dei en el Perú
Authors: de la Puente Brunke Manuel
Published: May 2024

La figura de José Agustín de la Puente Candamo en los inicios del Opus Dei en el Perú, vinculados al ambiente académico, principalmente en el Instituto Riva-Agüero de la Pontificia Universidad Católica del Perú.
José Agustín de la Puente. La virtud del servicio
Authors: Quiñones Tinoco Leticia
Published: May 2024

En los casi veinte años asistiendo al doctor José Agustín de la Puente Candamo en la biblioteca de su casa de Orbea, la autora recuerda a este insigne historiador y destaca la virtud de servicio.
ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
Authors: Veronese Matteo , Kallabis Sebastian , Kaczmarek Alexander Tobias , Das Anushka , Robers Lennart , Schumacher Simon , Lofrano Alessia , Brodesser Susanne , Müller Stefan , Hofmann Kay , Krüger Marcus , Rugarli Elena I
Published: May 2024

Complexes of ERLIN1 and ERLIN2 (ER lipid raft–associated 1 and 2) form large ring-like cup-shaped structures on the endoplasmic reticulum (ER) membrane and serve as platforms to bind cholesterol and E3 ubiquitin ligases, potentially defining functional nanodomains. Here, we show that ERLIN scaffolds mediate the interaction between the full-length isoform of TMUB1 (transmembrane and ubiquitin-like domain–containing 1) and RNF170 (RING finger protein 170). We identify a luminal N-terminal conserved region in TMUB1 and RNF170, which is required for this interaction. Three-dimensional modelling shows that this conserved motif binds the stomatin/prohibitin/flotillin/HflKC domain of two adjacent ERLIN subunits at different interfaces. Protein variants that preclude these interactions have been previously linked to hereditary spastic paraplegia. Using omics-based approaches in combination with phenotypic characterization of HeLa cells lacking both ERLINs, we demonstrate a role of ERLIN scaffolds in limiting cholesterol esterification, thereby favouring cholesterol transport from the ER to the Golgi apparatus and regulating Golgi morphology and the secretory pathway.
Doxastic Partiality and the Puzzle of Enticing Right Action
Authors: Lewis Max
Published: May 2024

It is common to think that our intimates are required to help us. But it can be problematic to appeal to certain kinds of facts (e.g., previous favors or prudentially relevant facts) in order to entice them to help us—even when those facts provide them with sufficient or decisive reason to help us. This is puzzling because, in these cases, our intimates have sufficient or decisive reason to act in the way we are trying to entice them to act. Moreover, it generally seems more problematic to appeal to certain kinds of facts (e.g., previous favors or prudentially relevant facts) in order to entice our intimates to do things that help us than it is to appeal to these facts in order to entice nonintimates to perform the same actions. This too is puzzling because one is usually permitted to ask more from one's intimates than non-intimates. I argue that these enticements are intuitively problematic because they indicate that one violates a demand of good intimate relationships. In particular, they indicate that one violates a demand for a certain kind of doxastic partiality; that is, one should trust one's intimates to follow what one's intimates know are demands of good intimate relationships. More specifically, one fails to trust one's intimates to be sufficiently motivated to protect or promote one's needs, desires, interests, projects, and well-being for one's own sake. Making such requests of nonintimates is not usually intuitively problematic because one is not required to trust non-intimates to be motivated in this way.
Elizabeth Anscombe on Murder
Authors: Stuchlik Joshua
Published: May 2024

The topic of murder was among Elizabeth Anscombe’s central preoccupations. Drawing on both her published writings and newly available archival resources, this paper reconstructs Anscombe’s theory of murder. I show that Anscombe was concerned to deny the semantic thesis that “murder” means “killing that is unjustified or impermissible” and I show how her theory surmounts three challenges that seem to support the semantic thesis. In doing so, I discuss her views on responsibility, the significance of the distinction between intention and foresight, and the concept of a title to kill.
Pemetaan Dampak Kerusakan Ekosistem Mangrove Terhadap Lingkungan Keamanan Maritim
Authors: Rinika Yuslita , Ras Abdul Rivai , Ras Abdul Rivai , Yulianto Bayu Asih , Yulianto Bayu Asih , Widodo Pujo , Widodo Pujo , Saragih Herlina Juni Risma , Saragih Herlina Juni Risma
Published: May 2024

Hutan Mangrove memberikan banyak manfaat untuk untuk kelangsungan hidup manusia di sektor lingkungan, hutan mangrove dapat menyerap karbon, mencegah intrusi laut, erosi dan abrasi pantai, peredam gelombang, filtrasi air dan nursery grown bagi beberapa jenis hewan terutama ikan. Di sisi ekonomi hutan mangrove dapat menjadi sumber penghidupan untuk masyarakat yang tinggal disekitarnya baik dengan eksploitasi sumberdaya yang ada dihutan mangrove maupun menjadikannya sebagai tempat wisata. Namun, total luas hutan mangrove yang luas dan iringi dengan berbagai manfaat hutan mangrove di ikuti dengan laju kerusakan hutan mangrove Indoesia yang termasuk tercepat di dunia. Penelitian ini menggunakan metode menggunakan studi pustaka kualitatif deskriptif dengan pendekatan Studi Literatur. Penelitian ini bertujuan untuk memetakan dampak kerusakan ekosistem mangrove terhadap lingkungan keamanan maritim.