bluuebunny/crossref_metadata_2025 huggingface dataset:
Antidepressant Drugs and COVID-19: A Review of Basic and Clinical Evidence
Authors: Mas Marta , García-Vicente Juan , Estrada-Gelonch Anaïs , Pérez-Mañá Clara , Papaseit Esther , Torrens Marta , Farré Magí
Published: July 2022

The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter development strategy in order to support clinicians with this difficult therapeutic dilemma. There is evidence to support the theory that some antidepressants can reduce concentrations of different cytokines in humans and animals and, recently, the antiviral activity of some antidepressants against SARS-CoV-2 has been reported. The aims of this narrative review are to evaluate the possible role of antidepressants in the treatment of COVID-19 infection and the possible benefits and risks of patients taking antidepressants for mental disorders and COVID-19 infection. A review was performed to analyse the current literature to identify the role of antidepressant medication in the treatment of COVID-19 patients. The electronic search was completed in MEDLINE and MedRxiv/BioRxiv for published literature and in ClinicalTrials.gov for ongoing clinical trials. The results show some evidence from preclinical data and observational studies about the possible efficacy of some specific antidepressants for treating COVID-19 infection. In addition, two published phase II studies testing fluvoxamine showed positive results for clinical deterioration and hospitalization rate versus a placebo. Seven ongoing clinical trials testing fluvoxamine, fluoxetine, and tramadol (as per its anti-inflammatory and antidepressant effect) are still in the early phases. Although the available evidence is limited, the sum of the antiviral and anti-inflammatory preclinical studies and the results from several observational studies and two phase II clinical trials provide the basis for ongoing clinical trials evaluating the possible use of antidepressants for COVID-19 infection in humans. Further investigations will be needed to support the possible use of antidepressants for this application.
Quantitative Measurements of Vessel Density and Blood Flow Areas Primary Angle Closure Diseases: A Study of Optical Coherence Tomography Angiography
Authors: Lin Bingying , Zuo Chengguo , Gao Xinbo , Huang Danping , Lin Mingkai
Published: July 2022

(1) Purpose: To measure the change in vessel density (VD) and the flow area (FA) on the retina of eyes with primary angle-closure diseases (PACD), including primary angle-closure suspect (PACS), primary angle-closure (PAC), acute primary angle-closure (APAC) and primary angle-closure glaucoma (PACG). (2) Methods: Patients with PACD were prospectively enrolled in this study. All participants underwent thorough ophthalmic examinations. The mean defect (MD), retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thickness, VD measurement, and blood FA were measured. (3) Results: A total of 147 eyes from 121 subjects were included in this study. The VD of the nerve head layer was significantly lower in PACG and APAC (all p < 0.001). APAC and PACG had lower FA of all layers, except for the choroid layer (p < 0.05). The macular VD of the whole image and blood FA in the superficial layer was significantly lower in PACG (all p < 0.001). The MD, RNFL, and GCC thickness demonstrated a strong correlation with whole image VD in the superficial layer (p < 0.001), while the inside disc VD did not show a significant correlation with MD, RNFL, and GCC thickness (p > 0.05). (4) Conclusions: There was a significant decrease in the VD and FA on the optic disc as well as the VD and FA of the superficial layer in the macular area in APAC and PACG. The changes in VD and FA are correlated with the severity of the glaucomatous structural damage and functional impairment.
Geographic Range Expansion and Taxonomic Notes of the Shortfin Neoscopelid Neoscopelus cf. microchir (Myctophiformes: Neoscopelidae) in the North-Eastern Atlantic
Authors: Bañón Rafael , Carlos Alejandro de , Acosta-Morillas Víctor , Baldó Francisco
Published: July 2022

One specimen of the shortfin neoscopelid Neoscopelus microchir Matsubara, 1943, has been recorded for the first time on the Porcupine Bank, southwestern Ireland, providing a new northern limit of distribution for the eastern Atlantic. Morphometric and meristic parameters confirm the taxonomic identification. However, DNA barcoding shows deficiencies in current taxonomy and the potential occurrence of cryptic species. On this basis, the specimen is cautiously reported as Neosopelus cf. microchir pending a taxonomic revision of the genus.
Multi-AUV Cooperative Navigation Algorithm Based on Temporal Difference Method
Authors: Ren Ranzhen , Zhang Lichuan , Liu Lu , Wu Dongwei , Pan Guang , Huang Qiaogao , Zhu Yuchen , Liu Yazhe , Zhu Zixiao
Published: July 2022

To reduce the cooperative positioning error and improve the navigation accuracy, a single master–slave AUV cooperative navigation method is proposed in this paper, which mainly focuses on planning the optimal path of the master AUV by the time difference (TD) method, under the premise that the path of the slave AUV has been planned. First, the model of multi-AUV cooperative navigation is established, and the observable problem of the system is analyzed. Second, for the single master–slave AUV cooperative navigation system, a Markov decision process (MDP)-based multi-AUV cooperative navigation model is established, and the master AUV path planning method is designed based on the TD method. Finally, the extended Kalman filter (EKF) and unscented Kalman filter (UKF) nonlinear filtering algorithms are applied to simulate and verify the algorithm that is proposed in this paper. The results show that the theoretical positioning error of the slave AUV can be controlled to about 3.2m by planning the path of the master AUV using the TD method. This method can not only reduce the observation error and positioning error of the slave AUV during the whole cooperative navigation process, but also keep the relative measurement distance between the master AUV and the slave AUV within an appropriate range.
So Close Yet So Far: Age and Growth of Blue Antimora Antimora rostrata (Moridae, Gadiformes, Teleostei) off New Zealand and Macquarie Island (Southwestern Pacific Ocean)
Authors: Korostelev Nikolai B. , Welsford Dirk C. , Belyakov Vladimir V. , Bush Andrei G. , Orlov Alexei M.
Published: July 2022

Age and growth of blue antimora Antimora rostrata were examined in the waters off New Zealand and Macquarie Island (southwestern Pacific). Samples off Macquarie Island were collected from bycatch in the Patagonian toothfish longline fishery. Individuals between 20 and 44 years in age measured between 37.6–71.1 cm in total length. Bottom trawl catches from New Zealand waters consisted of smaller and younger fish (11 to 38 years), measuring 22.5–52.5 cm long. The age classes with the greatest numbers in the former area were represented by fish aged 33–34 years (25.7%). In the latter area, the most numerous age classes were 21–23 years (12.1%), 28–29 years (17.6%), and 32 years (6.6%). The blue antimora from off the Macquarie Island show similar growth rates to those of individual fish from the Ross, Lazarev and Weddell Seas, waters off the Kerguelen and Crozet Islands, and southeastern Greenland. Individuals from New Zealand waters demonstrate the slowest growth rates compared to other parts of the species’ range but are quite similar to individuals from the Flemish Cap area. Further research to identify the stock structure of this broadly distributed species is warranted to provide context to differences in growth rates observed between populations.
Metabolic Plasticity of Candida albicans in Response to Different Environmental Conditions
Authors: Gallo Mariana , Giovati Laura , Magliani Walter , Pertinhez Thelma A. , Conti Stefania , Ferrari Elena , Spisni Alberto , Ciociola Tecla
Published: July 2022

The ubiquitous commensal Candida albicans, part of the human microbiota, is an opportunistic pathogen able to cause a wide range of diseases, from cutaneous mycoses to life-threatening infections in immunocompromised patients. Candida albicans adapts to different environments and survives long-time starvation. The ability to switch from yeast to hyphal morphology under specific environmental conditions is associated with its virulence. Using hydrogen nuclear magnetic resonance spectroscopy, we profiled the intracellular and extracellular metabolome of C. albicans kept in water, yeast extract–peptone–dextrose (YPD), and M199 media, at selected temperatures. Experiments were carried out in hypoxia to mimic a condition present in most colonized niches and fungal infection sites. Comparison of the intracellular metabolites measured in YPD and M199 at 37 °C highlighted differences in specific metabolic pathways: (i) alanine, aspartate, glutamate metabolism, (ii) arginine and proline metabolism, (iii) glycerolipid metabolism, attributable to the diverse composition of the media. Moreover, we hypothesized that the subtle differences in the M199 metabolome, observed at 30 °C and 37 °C, are suggestive of modifications propaedeutic to a subsequent transition from yeast to hyphal form. The analysis of the metabolites’ profiles of C. albicans allows envisaging a molecular model to better describe its ability to sense and adapt to environmental conditions.
Comparative Physiological and Transcriptome Analysis Provide Insights into the Response of Cenococcum geophilum, an Ectomycorrhizal Fungus to Cadmium Stress
Authors: Shi Yuyu , Yan Tianyi , Yuan Chao , Li Chaofeng , Rensing Christopher , Chen Yahua , Xie Rongzhang , Zhang Taoxiang , Lian Chunlan
Published: July 2022

Cadmium (Cd) displays strong toxicity, high mobility, and cannot be degraded, which poses a serious threat to the environment. Cenococcum geophilum (C. geophilum) is one of the most common ectomycorrhizal fungi (ECMF) in the natural environment. In this study, three Cd sensitive and three Cd tolerant strains of C. geophilum were used to analyze the physiological and molecular responses to Cd exposure. The results showed that Cd inhibited the growth of all strains of C. geophilum but had a less toxic effect on the tolerant strains, which may be correlated to a lower content of Cd and higher activity of antioxidant enzymes in the mycelia of tolerant strains. Comparative transcriptomic analysis was used to identify differentially expressed genes (DEGs) of four selected C. geophilum strains after 2 mg/L Cd treatment. The results showed that the defense response of C. geophilum strain to Cd may be closely related to the differential expression of functional genes involved in cell membrane ion transport, macromolecular compound metabolism, and redox pathways. The results were further confirmed by RT-qPCR analysis. Collectively, this study provides useful information for elucidation of the Cd tolerance mechanism of ECMF.
Functional Characterization of the M36 Metalloprotease FgFly1 in Fusarium graminearum
Authors: Wang Xintong , He Miaomiao , Liu Huanhuan , Ding Huiyi , Liu Kouhan , Li Ying , Cheng Peng , Li Qiang , Wang Baotong
Published: July 2022

Fungalysin metallopeptidase (M36), a hydrolase, catalyzes the hydrolysis of alanine, glycine, etc. Normally, it is considered to play an important role in the progress of fungal infection. However, the function of fungalysin metallopeptidase (M36) in Fusarium graminearum has not been reported. In this study, we explored the biological functions of FgFly1, a fungalysin metallopeptidase (M36) of F. graminearum. We found that ΔFgFly1 did not affect the ability to produce DON toxin, although it inhibited spore germination during asexual reproduction and reduction in pathogenicity compared with PH-1. Therefore, we speculated that FgFly1 affects the pathogenicity of F.graminearum by affecting pathways related to wheat disease resistance. Target protein TaCAMTA (calmodulin-binding transcription activator) was selected by a yeast two-hybrid (Y2H) system. Then, the interaction between FgFly1 and TaCAMTA was verified by bimolecular fluorescent complimentary (BiFC) and luciferase complementation assay (LCA). Furthermore, compared with wild-type Arabidopsis thaliana, the morbidity level of ΔAtCAMTA was increased after infection with F.graminearum, and the expression level of NPR1 was significantly reduced. Based on the above results, we concluded that FgFly1 regulated F. graminearum pathogenicity by interacting with host cell CAMTA protein.
Pressure Injuries and Management after Spinal Cord Injury
Authors: Vecin Nicole M. , Gater David R.
Published: July 2022

Spinal cord injury (SCI) results in motor paralysis and sensory loss that places individuals at particularly high risk of pressure injuries. Multiple comorbidities associated with autonomic, cardiovascular, pulmonary, endocrine, gastrointestinal, genitourinary, neurological, and musculoskeletal dysfunction makes it even more likely that pressure injuries will occur. This manuscript will review the structure and function of the integumentary system, and address the multidisciplinary approach required to prevent and manage pressure injuries in this vulnerable population.
Identification of Pathogenic Variant Burden and Selection of Optimal Diagnostic Method Is a Way to Improve Carrier Screening for Autosomal Recessive Diseases
Authors: Sotnikova Evgeniia A. , Kiseleva Anna V. , Kutsenko Vladimir A. , Zharikova Anastasia A. , Ramensky Vasily E. , Divashuk Mikhail G. , Vyatkin Yuri V. , Klimushina Marina V. , Ershova Alexandra I. , Revazyan Karina Z. , Skirko Olga P. , Zaicenoka Marija , Efimova Irina A. , Pokrovskaya Maria S. , Kopylova Oksana V. , Glechan Anush M. , Shalnova Svetlana A. , Meshkov Alexey N. , Drapkina Oxana M.
Published: July 2022

Cystic fibrosis, phenylketonuria, alpha-1 antitrypsin deficiency, and sensorineural hearing loss are among the most common autosomal recessive diseases, which require carrier screening. The evaluation of population allele frequencies (AF) of pathogenic variants in genes associated with these conditions and the choice of the best genotyping method are the necessary steps toward development and practical implementation of carrier-screening programs. We performed custom panel genotyping of 3821 unrelated participants from two Russian population representative samples and three patient groups using real-time polymerase chain reaction (PCR) and next generation sequencing (NGS). The custom panel included 115 known pathogenic variants in the CFTR, PAH, SERPINA1, and GJB2 genes. Overall, 38 variants were detected. The comparison of genotyping platforms revealed the following advantages of real-time PCR: relatively low cost, simple genotyping data analysis, and easier detection of large indels, while NGS showed better accuracy of variants identification and capability for detection of additional pathogenic variants in adjacent regions. A total of 23 variants had significant differences in estimated AF comparing with non-Finnish Europeans from gnomAD. This study provides new AF data for variants associated with the studied disorders and the comparison of genotyping methods for carrier screening.
Assessing Landscape Instability through Land-Cover Change Based on the Hemeroby Index (Lithuanian Example)
Authors: Jasinavičiūtė Agnė , Veteikis Darijus
Published: July 2022

The increasing anthropogenic impact on landscapes globally has increased interest in assessing landscape naturalness. This study assessed the changes in land cover in Lithuania and identified the most common reasons for land-use change. Coordination of Environment Information (CORINE) land-cover data were used to assess the changes in land cover naturalness in Lithuania from 1995 to 2018. Land-cover types were ranked according to the hemeroby index, ranging from natural landscape with no human impact to anthropogenic landscapes with excessively strong human impact. Land use trends in Lithuania were related to agricultural and forestry activities. During the analysed period, these areas decreased by as much as 11.19%, and the number of areas with a particularly strong impact from human activities also decreased. Land cover naturalness did increase in areas less suitable for agriculture. The impact of human activities on the naturalness of the landscape needs to be explored in detail at the local level, which should be followed by appropriate spatial-planning decisions to ensure ecological balance through as many sustainable solutions as possible, especially with the European Commission adoption the European Green Deal.
Mass Spectrometry Imaging Spatial Tissue Analysis toward Personalized Medicine
Authors: Gonçalves Juliana P. L. , Bollwein Christine , Schwamborn Kristina
Published: July 2022

Novel profiling methodologies are redefining the diagnostic capabilities and therapeutic approaches towards more precise and personalized healthcare. Complementary information can be obtained from different omic approaches in combination with the traditional macro- and microscopic analysis of the tissue, providing a more complete assessment of the disease. Mass spectrometry imaging, as a tissue typing approach, provides information on the molecular level directly measured from the tissue. Lipids, metabolites, glycans, and proteins can be used for better understanding imbalances in the DNA to RNA to protein translation, which leads to aberrant cellular behavior. Several studies have explored the capabilities of this technology to be applied to tumor subtyping, patient prognosis, and tissue profiling for intraoperative tissue evaluation. In the future, intercenter studies may provide the needed confirmation on the reproducibility, robustness, and applicability of the developed classification models for tissue characterization to assist in disease management.
Free Convection and Heat Transfer in Porous Ground Massif during Ground Heat Exchanger Operation
Authors: Basok Borys , Davydenko Borys , Koshlak Hanna , Novikov Volodymyr
Published: July 2022

Heat pumps are the ideal solution for powering new passive and low-energy buildings, as geothermal resources provide buildings with heat and electricity almost continuously throughout the year. Among geothermal technologies, heat pump systems with vertical well heat exchangers have been recognized as one of the most energy-efficient solutions for space heating and cooling in residential and commercial buildings. A large number of scientific studies have been devoted to the study of heat transfer in and around the ground heat exchanger. The vast majority of them were performed by numerical simulation of heat transfer processes in the soil massif–heat pump system. To analyze the efficiency of a ground heat exchanger, it is fundamentally important to take into account the main factors that can affect heat transfer processes in the soil and the external environment of vertical ground heat exchangers. In this work, numerical simulation methods were used to describe a mathematical model of heat transfer processes in a porous soil massif and a U-shaped vertical heat exchanger. The purpose of these studies is to determine the influence of the filtration properties of the soil as a porous medium on the performance characteristics of soil heat exchangers. To study these problems, numerical modeling of hydrodynamic processes and heat transfer in a soil massif was performed under the condition that the pores were filled only with liquid. The influence of the filtration properties of the soil as a porous medium on the characteristics of the operation of a soil heat exchanger was studied. The dependence of the energy characteristics of the operation of a soil heat exchanger and a heat pump on a medium with which the pores are filled, as well as on the porosity of the soil and the size of its particles, was determined.
Surface Quality Control Strategy of Aspherical Mold Based on Screw Feed Polishing of Small Polishing Tool
Authors: Zhang Jiarong , Wang Han , Zhu Xiangyou , Yao Honghui , Zhuo Shaomu , Ma Shuaijie , Zhan Daohua , Cai Nian
Published: July 2022

For small aspherical molds, it is difficult for the existing polishing method to take into account the correction of the surface error and the control of the uniformity of the surface roughness (SR) distribution, because the polishing tool is always larger than the small mold. Therefore, we used viscoelastic polyester fiber cloth to wrap the small steel ball as a polishing tool to adapt to the surface shape change of the aspherical mold, and designed a semi-flexible small polishing disc tool with microstructure, which can better adapt to the curvature change of aspherical surface and obtain better SR Ra. At the same time, a combined polishing method of constant speed and variable speed for screw feed was proposed to improve the uniformity of SR distribution in the paper. Then, a series of theoretical analysis and experimental verification were carried out in this paper to predict the tool influence function (TIF) of the two polishing tools and the effectiveness of the combined polishing method. In the experiment, a TIF bandwidth of about 0.46 mm was obtained with a small spherical polishing tool, which favors the surface shape correction of the small aspherical mold. The experiment of uniform removal with a small polishing disc tool was carried out to quickly reduce the Ra. Finally, the surface quality of the aspherical mold was effectively improved, combined with the constant speed and variable speed polishing modes of screw feed of the small spherical polishing tool and the smoothing effect of the small polishing disc tool. The peak valley (PV) of two small aspherical molds with an optical effective diameter less than 13 mm converged from 0.3572 μm and 0.2075 μm to 0.1282 μm and 0.071 μm, respectively. At the same time, the SR dispersion coefficient was reduced from 27.9% and 41.6% to 14.2% and 12.7%, respectively. The study provides a good solution for the surface quality control of small aspherical molds.
Disinfection and Biocompatibility of Titanium Surfaces Treated with Glycine Powder Airflow and Triple Antibiotic Mixture: An In Vitro Study
Authors: Alovisi Mario , Carossa Massimo , Mandras Narcisa , Roana Janira , Costalonga Massimo , Cavallo Lorenza , Pira Enrico , Putzu Maria Grazia , Bosio Davide , Roato Ilaria , Mussano Federico , Scotti Nicola
Published: July 2022

The aim of this in vitro study was to compare three disinfection protocols of biofilm-coated machined (MAC) and acid etched (SLA) commercial pure Grade 4 Titanium disks. Samples were infected with a vial of polymicrobial biofilm to simulate peri-implantitis in vitro. Seventeen MAC and twenty SLA titanium disks were randomly assigned to: (1) glycine powder air-flow (GYPAP) for 1 min; (2) a local delivered triple paste antibiotic composed by a gel mixture with ciprofloxacin, metronidazole, and clarithromycin (3MIX) for 1 h; and (3) a combination of both (GYPAP + 3MIX). Biocompatibility of the titanium disks after each treatment protocol was assessed by measurement of adhesion and growth of adipose-derived mesenchymal stem cells (ASCs) after 24 and 72 h. A confocal laser scanning microscope (CLSM) assessed the antibacterial effect of each treatment. Data of the antibacterial efficacy and cell viability were presented as mean with standard deviation and calculated by one-way ANOVA with multiple comparisons via Bonferroni tests. Results were considered significant with p < 0.05. The higher cell viability was achieved by the 3MIX and GYPAP combination on the SLA surfaces after 72 h. CLSM analysis showed a mean ratio of dead bacteria statistically higher in the 3MIX + GYPAP group compared with the GYPAP and 3MIX subgroups (p < 0.05). In conclusion, data showed that the combination of GYPAP and 3MIX could be preferred to the other protocols, especially in presence of SLA titanium surface.
Structural Performance of EB-FRP-Strengthened RC T-Beams Subjected to Combined Torsion and Shear Using ANN
Authors: Amini Pishro Ahad , Zhang Zhengrui , Amini Pishro Mojdeh , Liu Wenfang , Zhang Lili , Yang Qihong
Published: July 2022

This research study applied Artificial Neural Networks (ANNs) to predict and evaluate the structural responses of externally bonded FRP (EB-FRP)-strengthened RC T-beams under combined torsion and shear. Previous studies proved that, compared to reinforced concrete (RC) rectangular beams, RC T-beams performance in shear is significantly higher in structural analysis and design. The structural response of RC beams experiences a critical change while torsion moments are applied in load conditions. Fiber Reinforced Polymer (FRP) is used to retrofit the structural elements due to changing structural design codes and loadings, especially in earthquake-prone countries. We applied Finite Element Method (FEM) software, ABAQUS, to provide a precise numerical database of a set of experimentally tested FRP-retrofitted RC T-beams in previous research works. ANN predicted structural analysis results and Mean Square Error (MSE) and Multiple Determination Coefficients  (R2) proved the accuracy of this study. The MSE values that were less than 0.0009 and R2 values greater than 0.9960 showed that the ANN precisely fits the data. The consistency between analyzed experimental and numerical results demonstrated the accurate implication of ANN, MSE, and R2 in predicting the structural responses of EB-FRP- strengthened RC T-beams.
Investigation of Microstructural Features and Mechanical Characteristics of the Pressureless Sintered B4C/C(Graphite) Composites and the B4C-SiC-Si Composites Fabricated by the Silicon Infiltration Process
Authors: Jiang Tao
Published: July 2022

The B4C/C(graphite) composites were fabricated by employing a pressureless sintering process. The pressureless sintered B4C/C(graphite) composites exhibited extremely low mechanical characteristics. The liquid silicon infiltration technique was employed for enhancing the mechanical property of B4C/C(graphite) composites. Since the porosity of the B4C/C(graphite) composites was about 25–38%, the liquid silicon was able to infiltrate into the interior composites, thereby reacting with B4C and graphite to generate silicon carbide. Thus, boron carbide, silicon carbide, and residual silicon were sintered together forming B4C-SiC-Si composites. The pressureless sintered B4C/C(graphite) composites were transformed into the B4C-SiC-Si composites following the silicon infiltration process. This work comprises an investigation of the microstructure, phase composition, and mechanical characteristics of the pressureless sintered B4C/C(graphite) composites and B4C-SiC-Si composites. The XRD data demonstrated that the pressureless sintered bulks were composed of the B4C phase and graphite phase. The pressureless sintered B4C/C(graphite) composites exhibited a porous microstructure, an extremely low mechanical property, and low wear resistance. The XRD data of the B4C-SiC-Si specimens showed that silicon infiltrated specimens comprised a B4C phase, SiC phase, and residual Si. The B4C-SiC-Si composites manifested a compact and homogenous microstructure. The mechanical property of the B4C-SiC-Si composites was substantially enhanced in comparison to the pressureless sintered B4C/C(graphite) composites. The density, relative density, fracture strength, fracture toughness, elastic modulus, and Vickers hardness of the B4C-SiC-Si composites were notably enhanced as compared to the pressureless sintered B4C/C(graphite) composites. The B4C-SiC-Si composites also manifested outstanding resistance to wear as a consequence of silicon infiltration. The B4C-SiC-Si composites demonstrated excellent wear resistance and superior mechanical characteristics.
Study on Plant Crushing and Soil Throwing Performance of Bionic Rotary Blades in Cyperus esculentus Harvesting
Authors: Zhu Hao , Wang Dongwei , He Xiaoning , Shang Shuqi , Zhao Zhuang , Wang Haiqing , Tan Ying , Shi Yanxin
Published: July 2022

Soil blocking and plant entanglement are the main challenges in Cyperus esculentus harvesting and excavating. The structure of the rotary blade is one of the critical factors affecting plant crushing and soil throwing performance. Inspired by the composite motion of longitudinal soil cutting and lateral soil throwing of the oriental mole cricket, a bionic rotary blade was designed with the contour curve of the excavation edge and excavation surface of its forefoot claw toe. The bionic rotary blade’s mechanical and kinematic analysis revealed its cutting mechanism. A flexible plant soil, bionic, rotary blade discrete element model was developed to simulate the Cyperus esculentus digging process. The optimal excavation edge and excavation surface were selected by a single factor experiment, and the optimal operating parameters of the bionic rotary blade were obtained by quadratic regression orthogonal rotational combination design. The results showed that the bionic rotary blade, based on the excavation edge and excavation surface of mole cricket first claw toe, had the longest throwing distance and the largest number of broken bonds. The best combination of operating parameters of the bionic rotary blade was 11.16 mm for blade spacing, 0.66 m/s for forward speed, and 300 rpm for shaft speed. The field experiment was carried out according to the best parameters. The results showed that the bionic rotary blade’s average soil throwing distance and plant crushing rate were 632.30 mm and 81.55%, respectively; thereby, not only meeting the requirements of Cyperus esculentus harvesting, but proving superior to the operation performance of the Chinese standard rotary blade IT245 and rotary blade with optimized cutting edge (IT245P). The results of this study can provide bionic design ideas and methods for the design of soil-cutting-based tillage machinery’s soil-engaging components, such as the rotary blade and returning blade.
Electrical Machines Winding Technology: Latest Advancements for Transportation Electrification
Authors: Selema Ahmed , Ibrahim Mohamed N. , Sergeant Peter
Published: July 2022

The ever-increasing demand for higher-power dense electrical machines has resulted in different electrical, mechanical, and thermal stresses, which can eventually cause machine failure. For this reason, the management of stresses and losses must be thoughtfully investigated to have a highly reliable electrical machine. The literature agrees that winding losses are the dominant loss mechanism in many electrical machines. However, statements vary on how to mitigate these losses along with the aforementioned stresses. To avoid winding failure, a study of the various winding topologies would allow for a better consideration of the challenges and limitations in the performance of different electrical machines. To this aim, this paper introduces a comprehensive review for different winding topologies. Many reported cases in the literature are summarized and compared. Moreover, the utilization of additive manufacturing (AM) in the production of the machine windings is presented, showing a high level of maturity of this emerging technology. Finally, different challenges facing the design of machine windings are introduced including the AC high frequency losses, thermal management, mechanical and acoustic problems, insulation aging, automated production, and winding manufacturability.
Electrically Small Wideband Monopole Antenna Partially Loaded with Low Loss Magneto-Dielectric Material
Authors: Kabalan Aladdin , Sharaiha Ala , Tarot Anne-Claude
Published: July 2022

A miniaturized new topology of the planar monopole antenna using a Magneto-Dielectric Material (MDM) is proposed in this paper. The antenna element is realized by introducing slots partially covered by the MDM. We optimized and modified the MDM topology and dimensions to enhance the impact of this material on the planar monopole antenna, including slots in its structure. This new monopole shows a miniaturization rate of 60% of the antenna’s height (51 cm antenna’s height is miniaturized to 20 cm) by covering only 5% of the antenna surface by the MDM. The measured results show the antenna’s central working frequency of 130 MHz, while the bandwidth is 30% using a broadband matching circuit using the Real Frequency Technique (RFT).
State Machines and Hypergroups
Authors: Massouros Gerasimos G. , Massouros Christos G.
Published: July 2022

State machines are a type of mathematical modeling tool that is commonly used to investigate how a system interacts with its surroundings. The system is thought to be made up of discrete states that change in response to external inputs. The state machines whose environment is a two-element magma are investigated in this study, focusing on the case when the magma is a group or a hypergroup. It is shown that state machines in any two-element magma can only have up to three states. In particular, the quasi-automata and quasi-multiautomata state machines are described and enumerated.
Hölder Inequalities for a Generalized Subclass of Univalent Functions Involving Borel Distributions
Authors: Murugusundaramoorthy Gangadharan , Cotîrlǎ Luminiţa-Ioana
Published: July 2022

In this article, by making use of the Borel distributions series, we introduce a new family of normalized holomorphic functions in the open unit disk and investigate necessary and sufficient conditions for functions f to be in this new class. Furthermore, results on the modified Hadamard product, Hölder inequalities, and closure properties under integral transforms and subordination results are discussed in detail.
Epoxinnamide: An Epoxy Cinnamoyl-Containing Nonribosomal Peptide from an Intertidal Mudflat-Derived Streptomyces sp.
Authors: Kang Sangwook , Han Jaeho , Jang Sung Chul , An Joon Soo , Kang Ilnam , Kwon Yun , Nam Sang-Jip , Shim Sang Hee , Cho Jang-Cheon , Lee Sang Kook , Oh Dong-Chan
Published: July 2022

Cinnamoyl-containing nonribosomal peptides (CCNPs) form a unique family of actinobacterial secondary metabolites and display various biological activities. A new CCNP named epoxinnamide (1) was discovered from intertidal mudflat-derived Streptomyces sp. OID44. The structure of 1 was determined by the analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data along with a mass spectrum. The absolute configuration of 1 was assigned by the combination of advanced Marfey’s method, 3JHH and rotating-frame overhauser effect spectroscopy (ROESY) analysis, DP4 calculation, and genomic analysis. The putative biosynthetic pathway of epoxinnamide (1) was identified through the whole-genome sequencing of Streptomyces sp. OID44. In particular, the thioesterase domain in the nonribosomal peptide synthetase (NRPS) biosynthetic gene cluster was proposed as a bifunctional enzyme, which catalyzes both epimerization and macrocyclization. Epoxinnamide (1) induced quinone reductase (QR) activity in murine Hepa-1c1c7 cells by 1.6-fold at 5 μM. It also exhibited effective antiangiogenesis activity in human umbilical vein endothelial cells (IC50 = 13.4 μM).
Leptomeningeal Carcinomatosis in a Patient with Pancreatic Cancer: A Rare Phenomenon?
Authors: Sayanagi Taichi , Ohishi Yumiko , Katayama Makoto , Tamura Ryota
Published: July 2022

Complication of leptomeningeal carcinomatosis (LMC) is critical. It causes rapid neurological deterioration, and subsequently, discontinuation of the ineffective treatment even in body tumor dormancy. Large molecular chemotherapeutic agents that are unlikely to penetrate the CSF space, are more likely to not treat LMC, typically in chemo-sensitive tumors. With the introduction of novel regimens, significant advances in overall survival have been observed even in formerly chemo-resistant tumors, such as pancreatic cancer. Although such cases are still rare, the number of pancreatic cancer patients complicated with LMC are increasing, and this therefore needs more recognition. A 49-year-old woman was diagnosed with stage IVa pancreatic cancer. She underwent surgery, and subsequent adjuvant chemotherapy. After three lines of chemotherapy over a 3-year period, where the body disease remained dormant, the patient was complicated by LMC. The diagnosis was made 4 months after the onset of headache. The patient received intrathecal methotrexate treatment but succumbed shortly after treatment induction. Pancreatic cancer is still relatively chemo-resistant and is one of the least likely types of tumor to be complicated by LMC due to patients dying of the primary tumor. Advancements in treatments have led to a prolonged period of primary tumor control, but not in the CNS due to the poor penetration of chemo-agents to this site. The present case seems to be a typical result of modern era anti-cancer therapy. Therefore, we emphasize the necessity of earlier recognition of this complication so that we can initiate specific treatment targeting the CSF space, especially in this formerly chemo-resistant tumor in order to improve its prognosis.
Modeling and Simulation of Metallurgical Processes in Ironmaking and Steelmaking
Authors: Echterhof Thomas , Ohno Ko-Ichiro , Visuri Ville-Valtteri
Published: July 2022

The UN’s 2030 Sustainable Development Goals, the Paris Agreement, and the European Green Deal, among other goals, all aim to improve the sustainability of industrial production and reduce CO2 emissions [...]
Nasal Microbiota, Olfactory Health, Neurological Disorders and Aging—A Review
Authors: Thangaleela Subramanian , Sivamaruthi Bhagavathi Sundaram , Kesika Periyanaina , Bharathi Muruganantham , Chaiyasut Chaiyavat
Published: July 2022

The nasal region is one of the distinct environments for the survival of various microbiota. The human microbial niche begins to inhabit the human body right from birth, and the microbiota survive as commensals or opportunistic pathogens throughout the life of humans in their bodies in various habitats. These microbial communities help to maintain a healthy microenvironment by preventing the attack of pathogens and being involved in immune regulation. Any dysbiosis of microbiota residing in the mucosal surfaces, such as the nasal passages, guts, and genital regions, causes immune modulation and severe infections. The coexistence of microorganisms in the mucosal layers of respiratory passage, resulting in infections due to their co-abundance and interactions, and the background molecular mechanisms responsible for such interactions, need to be considered for investigation. Additional clinical evaluations can explain the interactions among the nasal microbiota, nasal dysbiosis and neurodegenerative diseases (NDs). The respiratory airways usually act as a substratum place for the microbes and can act as the base for respiratory tract infections. The microbial metabolites and the microbes can cross the blood–brain barrier and may cause NDs, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and multiple sclerosis (MS). The scientific investigations on the potential role of the nasal microbiota in olfactory functions and the relationship between their dysfunction and neurological diseases are limited. Recently, the consequences of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) in patients with neurological diseases are under exploration. The crosstalk between the gut and the nasal microbiota is highly influential, because their mucosal regions are the prominent microbial niche and are connected to the olfaction, immune regulation, and homeostasis of the central nervous system. Diet is one of the major factors, which strongly influences the mucosal membranes of the airways, gut, and lung. Unhealthy diet practices cause dysbiosis in gut microbiota and the mucosal barrier. The current review summarizes the interrelationship between the nasal microbiota dysbiosis, resulting olfactory dysfunctions, and the progression of NDs during aging and the involvement of coronavirus disease 2019 in provoking the NDs.
Assessment of the Effect of Organic Matter on Rare Earth Elements and Yttrium Using the Zhijin Early Cambrian Phosphorite as an Example
Authors: Wu Shengwei , Yang Haiying , Fan Haifeng , Xia Yong , Meng Qingtian , He Shan , Gong Xingxiang
Published: July 2022

The geochemistry of rare earth elements and yttrium (REY) in phosphorite has been widely studied. However, the effect of organic matter on REY enrichment has not been well determined. We utilized paired inorganic (δ13Ccarb) and organic (δ13Ccarb) carbon isotopes, total organic carbon (TOC), and REY content (∑REY) of the Zhijin Motianchong (MTC) phosphorite and compared them with those of Meishucun (MSC) phosphorite to reveal the effect of organic matter on REY. The δ13Ccarb of the MTC area (≈0‰) is heavier than that of the MSC area (−5.23‰ to −1.13‰), whereas δ13Corg is lighter (−33.85‰ to −26.34‰) in MTC than in MSC (−32.95‰ to −25.50‰). Decoupled δ13Ccarb and δ13Corg in MTC indicate the contribution of chemoautotrophic organisms or methanotrophic bacteria. Compared to the MSC phosphorite, the MTC phosphorite has higher ∑REY and TOC, and these parameters have a positive relationship. MTC phosphorite has REY patterns resembling those of contemporary organic matter. Furthermore, dolomite cement has a higher ∑REY than dolomite in the phosphorus-bearing dolostone. Additionally, pyrites are located on the surface of fluorapatite in the Zhijin phosphorites. It is reasonable to suggest that the REY was released into the pore water owing to the anaerobic oxidation of organic matter at the interface between seawater and sediment, resulting in the REY enrichment of Zhijin phosphorites.
Lead Isotopes and the Sources of Granitic Magmas: The Sveconorwegian Granite and Pegmatite Province of Southern Norway
Authors: Rosing-Schow Nanna , Andersen Tom , Müller Axel
Published: July 2022

Lead isotope analyses of K-feldspar from late Sveconorwegian (900–1000 Ma) granitic pegmatites and A-type, ferroan granitic intrusions in four different areas of southern Norway analyzed by laser-ablation inductively coupled plasma source mass spectrometry (LA-ICPMS) give compositions in the range 206Pb/204Pb = 16.637 to 17.555, 207Pb/204Pb = 15.445 to 15.534, 208Pb/204Pb = 36.317 to 37.459. These compositions broadly overlap with the initial compositions estimated from previously published solution TIMS whole-rock and feldspar Pb isotope analyses of late Sveconorwegian granitic plutons across the region, suggesting that magmas forming A-type granite plutons and granitic pegmatites have been derived from broadly similar source rocks, i.e., from a continental crust that initially formed in Palaeoproterozoic time (ca. 2.10–1.86 Ga), and subsequently underwent intracrustal partial melting, differentiation and rejuvenation via mafic underplating in Mesoproterozoic time.
Insights on the Modulation of SIRT5 Activity: A Challenging Balance
Authors: Mori Matteo , Cazzaniga Giulia , Meneghetti Fiorella , Villa Stefania , Gelain Arianna
Published: July 2022

SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field.
The Influence of Tyrosol-Enriched Rhodiola sachalinensis Extracts Bioconverted by the Mycelium of Bovista plumbe on Scopolamine-Induced Cognitive, Behavioral, and Physiological Responses in Mice
Authors: Kwon Mi-Jin , Lee Ju-Woon , Kim Kwan-Soo , Chen Hao , Cui Cheng-Bi , Lee Gye Won , Cho Young Ho
Published: July 2022

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by cognitive deficits, which are accompanied by memory loss and cognitive disruption. Rhodiola sachalinensis (RSE) is a medicinal plant that has been used in northeastern Asia for various pharmacological activities. We attempted to carry out the bioconversion of RSE (Bio-RSE) using the mycelium of Bovista plumbe to obtain tyrosol-enriched Bio-RSE. The objective of this study was to investigate the effects of Bio-RSE on the activation of the cholinergic system and the inhibition of oxidative stress in mice with scopolamine (Sco)-induced memory impairment. Sco (1 mg/kg body weight, i.p.) impaired the mice’s performance on the Y-maze test, passive avoidance test, and water maze test. However, the number of abnormal behaviors was reduced in the groups supplemented with Bio-RSE. Bio-RSE treatment improved working memory and avoidance times against electronic shock, increased step-through latency, and reduced the time to reach the escape zone in the water maze test. Bio-RSE dramatically improved the cholinergic system by decreasing acetylcholinesterase activity and regulated oxidative stress by increasing antioxidant enzymes (superoxide dismutase (SOD) and catalase (CAT)). The reduction in nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling in the brain tissue due to scopolamine was restored by the administration of Bio-RSE. Bio-RSE also significantly decreased amyloid-beta 1–42 (Aβ1–42) and amyloid precursor protein (APP) expression. Moreover, the increased malondialdehyde (MDA) level and low total antioxidant capacity in Sco-treated mouse brains were reversed by Bio-RSE, and an increase in Nrf2 and HO-1 was also observed. In conclusion, Bio-RSE protected against Sco-induced cognitive impairment by activating Nrf2/HO-1 signaling and may be developed as a potential beneficial material for AD.
The Wako-Saitô-Muñoz-Eaton Model for Predicting Protein Folding and Dynamics
Authors: Ooka Koji , Liu Runjing , Arai Munehito
Published: July 2022

Despite the recent advances in the prediction of protein structures by deep neutral networks, the elucidation of protein-folding mechanisms remains challenging. A promising theory for describing protein folding is a coarse-grained statistical mechanical model called the Wako-Saitô-Muñoz-Eaton (WSME) model. The model can calculate the free-energy landscapes of proteins based on a three-dimensional structure with low computational complexity, thereby providing a comprehensive understanding of the folding pathways and the structure and stability of the intermediates and transition states involved in the folding reaction. In this review, we summarize previous and recent studies on protein folding and dynamics performed using the WSME model and discuss future challenges and prospects. The WSME model successfully predicted the folding mechanisms of small single-domain proteins and the effects of amino-acid substitutions on protein stability and folding in a manner that was consistent with experimental results. Furthermore, extended versions of the WSME model were applied to predict the folding mechanisms of multi-domain proteins and the conformational changes associated with protein function. Thus, the WSME model may contribute significantly to solving the protein-folding problem and is expected to be useful for predicting protein folding, stability, and dynamics in basic research and in industrial and medical applications.
Anchoring NiO Nanosheet on the Surface of CNT to Enhance the Performance of a Li-O2 Battery
Authors: Chen Shuang , Wang Shukun , Dong Yunyun , Du Hongmei , Zhao Jinsheng , Zhang Pengfang
Published: July 2022

Li2O2, as the cathodic discharge product of aprotic Li-O2 batteries, is difficult to electrochemically decompose. Transition-metal oxides (TMOs) have been proven to play a critical role in promoting the formation and decomposition of Li2O2. Herein, a NiO/CNT catalyst was prepared by anchoring a NiO nanosheet on the surface of CNT. When using the NiO/CNT as a cathode catalyst, the Li-O2 battery had a lower overpotential of 1.2 V and could operate 81 cycles with a limited specific capacity of 1000 mA h g−1 at a current density of 100 mA g−1. In comparison, with CNT as a cathodic catalyst, the battery could achieve an overpotential of 1.64 V and a cycling stability of 66 cycles. The introduction of NiO effectively accelerated the generation and decomposition rate of Li2O2, further improving the battery performance. SEM and XRD characterizations confirmed that a Li2O2 film formed during the discharge process and could be fully electrochemical decomposed in the charge process. The internal network and nanoporous structure of the NiO/CNT catalyst could provide more oxygen diffusion channels and accelerate the decomposition rate of Li2O2. These merits led to the Li-O2 battery’s better performance.