bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Green Accounting, Kinerja Lingkungan dan Ukuran Perusahaan Terhadap Financial performance (Studi Kasus pada Perusahaan Sektor Pertambangan yang Terdaftar di Bursa Efek Indonesia Tahun 2017-2018)
Authors: Dita Eka Mutia Anin , Ervina Deasy
Published: June 2022

The mining sectorial is an industry that directly related to nature so the activities carried out will have an impact on enviromental sustaibibility around it. If the company take so much care to enviromental factor maybe there is an impact to firm’s financial performance. This study aims to examine and anlyze  the effect of green accounting, enviromental performance and firm size on the financial performance of companies that listed on Indonesian Stock Exchange from 2017-2018 in mining sector. This research using a purposive sampling methode which has 34 firm samples. The result show that green accounting has no effect to financial performance, enviromental performance effects on financial performance and firm size has no effect to financial performance.
Keywords :Green Accounting; Enviromental Performance; Firm Size; Financial performance
Analisis Efisiensi Penentuan Harga Pokok Produksi dengan Metode Full Costing pada Peternak Lele di Desa Blimbing Kecamatan Gudo Kabupaten Jombang (Studi Kasus pada Peternakan milik Pak Sukirno)
Authors: Tita Rahmawati Silvia , Ari Pertiwi Dwi
Published: June 2022

Harga pokok produksi yakni tarif yang dikeluarkan pada pengolahan bahan mentah menjadi output. Tujuan utama penelitian ini yaitu agar bisa memahami perhitungan yang digunakan pada peternak ikan lele sudah memperhitungkan dengan benar dan membandingkan serta menghitung kesesuaian peenjumlahan harga pokok produksi sesuai dengan metode penuh. Dari hasil penelitian ini memperlihatkan bahwa perhitungan harga pokok produksi milik peternak ikan lele di Desa Blimbing Kecamatan Gudo Jombang menerapkan perhitungan dengan menambahkan biaya bahan baku dan biaya overhead pabrik. Pada metode penuh ini dijelaskan bahwa metode ini Mempertimbangkan semua elemen biaya produksi, termasuk biaya bahan baku, biaya tenaga kerja langsung dan biaya pabrik tidak langsung, termasuk variabel perilaku dan perilaku konstan, mengolah biaya produksi ternak ikan lele di Desa Blimbing Kecamatan Gudo Jombang belum sepenuhnya sesuai dengan metode penuh.
Kata Kunci: Full Costing, Harga Pokok Produksi, Harga Pokok Produk
Pengaruh Earning Per Share (EPS) dan Ukuran Perusahaan terhadap Harga Saham (Studi Pada Perusahaan Manufaktur Sub Sektor Makanan dan Minuman Yang Listing Di BEI Periode 2016-2018)
Authors: Fadlan Ali Mohammad , Agustina Rachma
Published: June 2022

Harga saham mencerminkan nilai suatu perusahaan, semakin tinggi nilai perusahaan secara tidak langsung berpengaruh pada harga saham juga akan meningkat. Penelitian ini dilakukan untuk mengetahui  pengaruh Earning Per Share (EPS) dan Ukuran perusahaan terhadap Harga Saham pada perusahaan makanan dan minuman yang Listing di BEI periode 2016-2018. Sampel pada penelitian ini sebanyak 11 perusahaan dengan teknik purposive sampling. Jenis penelitian yang digunakan yaitu penelitian kuantitatif. Hasil dari penelitian ini menunjukkan bahwa Earning Per Share (EPS) berpengaruh signifikan terhadap Harga Saham, sedangkan Ukuran Perusahaan tidak berpengaruh signifikan terhadap harga saham.
 Kata kunci: Earning Per Share, Ukuran Perusahaan, Harga Saham
Pengaruh Penghindaran Pajak (Tax Avoidance) Terhadap Biaya Utang (Study pada Perusahaan Food and Beverages di Bursa Efek Indonesia 2018-2020)
Authors: Musaddad Abdullah , Agustina Rachma
Published: June 2022

This study aims to determine the effect of tax avoidance on the cost of debt in food and beverages companies on the IDX for the 2018-2020 period. Using quantitative methods with secondary data in the form of financial statements of food and beverages companies on the IDX for the 2018-2020 period. Sampling used purposive sampling of 14 food and beverages companies on the IDX for the 2018-2020 period. The data is processed using SPSS with the results of the study showing that tax avoidance has no effect on the cost of debt.
Keywords: Tax Avoidance ; Cost of Debt
Faktor-Faktor Yang Mempengaruhi Audit Delay (Study pada Perusahaan Food and Beverages di Bursa Efek Indonesia 2018-2020)
Authors: Afifah Yuliana
Published: June 2022

Public companies are required to publish financial statements in time that has been set by the OJK which is lees than 120 days.  The delay of the company in the publish financial statements to give effect to the good name of the company and the trust investor that can make declining investor confidence to the company. One of the companies that experienced a delay in the publishing of financial statements Food and Beverages Companies on the IDX in 2018-2020. Purpose of the study is determine of the factors that effect audit delay. Data analysis in this study used the logistic regression method.  The results of this study indicate that company size has no effect on audit delay in food and beverages companies on the IDX 2018-2020, leverage does not affect audit delay on food and beverages companies on the IDX 2018-2020, KAP size does not affect audit delay on food companies.  and beverages on the IDX 2018-2020, and the auditor's opinion has an effect on audit delay in food and beverages companies on the IDX 2018-2020.
 Keywords: Firm Size; Leverage; KAP Size; Auditor Opinion; Audit Delay
Analisis Penentuan Harga Jual berdasarkan Metode Variable Costing dan Job Order Costing pada IKM Sabda Batik Ecoprint
Authors: Hestiningsih Wiwik
Published: June 2022

Company would expect the maximum profit for his efforts. The achievement of profit maximally strongly influenced by the calculation of the cost of production, the determination of the selling price, and sales volume of a product appropriately. This study aims to determine the calculation of the cost of production in IKM Sabda Batik Ecoprint Jombang in determining the selling price and the next will be compared with the calculations of the researchers using the method of variable costing and job order costing. Types of research method used is qualitative research with descriptive approach. The information in the qualitative method is obtained by means of observation, interview, and documentation. The results showed that the calculation of cost of production in IKM Sabda Batik Ecoprint Jombang using the method of full costing. The calculation is to obtain a higher yield than the calculation of the cost of production based on the method of variable costing and job order costing. These results are aligned with the determination of the product selling price fabric ecoprint is the selling price per unit based on the method of full costing obtain a result that is higher than the selling price per unit based on the method of variable costing and job order costing.
Key words: Selling price; variable costing; Job Order Costing
Pengaruh Kondisi Keuangan, Disclosure, Opini Audit pada Tahun Sebelumnya Terhadap Opini Audit Going Concern (Studi Kasus pada Perusahaan Wholesale and Retail Trade di BEI Tahun 2019-2020)
Authors: Wahyuni Ririn , Pertiwi Dwi Ari
Published: June 2022

The purpose of this research is to find out the influence of financial conditions, disclosures and audit opinions during the previous year on the Going Concern Audit Opinion in Wholesale and Retail Trade companies listed on the IDX in 2019-2020. The sample technique in this research is using purposive sampling technique and obtained a sample of 66 Wholesale and Retail Trade companies listed on the IDX in 2019-2020. Logistic regression method was used to analyze the data in the study. The results of the study indicate that financial conditions have no effect on going concern audit opinion, this is represented by a significance value of 0.700 which is greater than 0.05. Meanwhile, the disclosure has an impact on the going concern audit opinion with the resulting value being 0.000 less than 0.05, and last year's audit opinion does not affect the going concern audit opinion, because the significance value is 0.290 greater than 0.05.
 Keywords: Financial Conditio; Disclosure; Audit Opinion in Previous Year; Audit Opinion Going Concern
Faktor yang Berpengaruh Pada Auditor Switching (Studi Pada BUMN Yang Listing di BEI 2018-2020)
Authors: Ma'summah Zety
Published: June 2022

This study aims to examine the effect of financial distress, management turnover, KAP size, partial audit opinion on auditor switching. The sample technique used in this study uses purposive sampling and obtained a sample of 48 BUMN companies listed on the IDX in 2018-2020.  Data analysis used logistic regression method.  The test results show that the audit opinion has no effect on auditor switching due to the significance level of 0.466, greater than 5%.  KAP size has no effect on auditor switching because the significance level value is 0.763, which is greater than 5%.  Management changes have no effect on auditor switching due to value.  The significance obtained is 0.941, greater than 5%. Financial distress has no effect on auditor switching because the significance value is 0.243, which is greater than 5%.
 Key words: Auditor Switching; Audit Opinion; KAP Size; Management Change;Financial Distress.
Implementasi Program Peduli Fakir Miskin Dalam Upaya Pemberdayaan Dana Zakat Pada Mustahik
Authors: Yanti Novia Indra , Umar As’ad
Published: June 2022

Poverty is a problem that remains unresolved, one of the causes of poverty is that muzaki in paying zakat is done in the traditional way, such as muzaki paying zakat there is still one that gives directly to mustahik. This research was conducted to find out the implementation of zakat fund empowerment in mustahik in LAZISMU Jombang through caring for the poor and to know the impact of the poor caring program in LAZISMU Jombang in an effort to empower zakat funds in mustahik. The research method used is qualitative with descriptive analysis through a phenomenological approach, besides that the author also uses library research and field research. Data collection techniques that are carried out are interviews, observation, and documentation. The results of this study indicate that the implementation of empowerment of zakat funds on mustahik in LAZISMU through caring for the poor is a form of empowerment, a mechanism for proposing mustahik, mechanisms for determining assistance, training and skills, mustahik business management, mechanisms for delivering assistance, and assistance mechanisms. The impact of the program on caring for the poor at LAZISMU Jombang in an effort to empower zakat funds in mustahik is to increase business capital, increase business, implement Islamic business ethics, and the ability to pay ZIS
Upaya Meningkatkan Pendapatan Ekonomi Mustahik Melalui Program Sentra Ternak Mandiri (STM) di Lembaga Amil Zakat Ummul Quro (LAZ-UQ) JOMBANG
Authors: Ulfa Maria
Published: June 2022

The research purpose to know implementation program livestock center (STM) and the Mustahik economic revenue of the independent livestock program at the institution Amil Zakat Ummul Quro (LAZ-UQ) Jombang. The method used in this study is qualitative research method. The data collection techniques use interviews, observation and documentation. The data analysis techniques used is a data reduction, data presentation and data deduction. Research shows that the implementation of the independent livestock center program (STM) requires a few steps there are: location survey of implementation program, assessment of prospective members, companion selection, formation of livestock groups, submission of seeds and implementation program, mentoring process, counseling and training, monitoring and evaluation. Post implementation of an independent livestock center program (STM) has been proven to increase Mustahik economics income as well as improve the quality of life. From the sale of the sheep can be used to needing necessary daily, or for education costs. Besides these result can also improve the condition of the house, build a small shop, some even buy motorbikes
Pengaruh Kualitas Layanan Terhadap Kepuasan Muzakki ( Studi Kasus Pada Lembaga Sosial Pesantren Tebuireng Jombang )
Authors: Basri Hasan , Sopingi Imam , Sudarwanto Tri
Published: June 2022

The competition of Social Institutions in Jombang is very fast, Each institution competes to gain the trust of the community in order to channel the assets of the agency. Strictly speaking, competition for Social Institutions requires a lot of effort to maintain the weaknesses of protection. The success of this business is largely determined by the ability of the institution to provide quality services. The purpose of this research is to study the factors of service quality for muzakki (case study in LSPT). Data collection conducted in this study is by collecting, interviewing, library research, questionnaire collection using a Likert scale and non probolity sampling methods, namely incidental sampling with slovin formula as many as 104. The method used is multiple regression. The results showed that X1 (physical evidence) had a significant effect on muzaki satisfaction where the significance value was greater than 5%, that is 0.05 with t count (2.692)> t table (1.983). X2 (reliability) is significant with the value of t arithmetic (2.762)> t table. (1,983). X3 (responsiveness) has a significant effect on the value of t arithmetic (3.393)> t table (1.983). X4 is not significant to satisfaction with t arithmetic (- 2,413)> t table (1,983). X5 (Empathy) has a significant effect on muzakki satisfaction with t arithmetic (2.582)> t table (1.983)
Implementasi Akad Murabahah dalam Pembiayaan Produktif pada KSPPS BMT NU Jombang
Authors: Andika Muhammad , Rosyadi M. Syam'un
Published: June 2022

Akad murabahah sebagai pembiayaan mendominasi di lembaga keuangan syariah. Akan tetapi dalam praktiknya terdapat masalah salah satunya berkaitan dengan penerapan dan waktu pelaksanaan akad tersebut. Tujuan penelitian mengetahui Implementasi Akad Murabahah dalam Pembiayaan Produktif yang dilakukan oleh KSPPS BMT NU Jombang beserta penerapan prinsip-prinsip syariah yang ada didalamnya. Pendekatan penelitian menggunakan pendekatan deskriptif kualitatif yang bersifat naturalistik, pada kondisi yang alamiah pada objek yang apa adanya dan tidak dimanipulasi. Hasil menunjukan implementasi akad murabahah dalam pembiayaan produktif pada KSPPS BMT NU Jombang adalah menggunakan akad murabahah bil wakalah. Penerapan tersebut dilakukan melalui dua tahap yaitu tahap awal dan tahap akhir. Sedangkan dalam penerapan prinsip-prinsip syariah terdapat penerapan yang sesuai dan ada yang tidak sesuai dengan prinsip syariah dan secara garis besar dapat disimpulkan bahwa pelaksanaan akad murabahah bil wakalah yang dilakukan oleh KSPPS BMT NU Jombang belum sesuai dengan ketentuan peraturan Fatwa Dewan Syariah Nasional Nomor 04/DSN-MUI/IV/2000 tentang Murabahah.
Peran Baitul Maal Wa Tamwil (BMT) Usaha Gabungan Terpadu (UGT) Sidogiri Dalam Pemberdayaan Pedagang Mikro
Authors: Elya Zuliana  , Ajib Ridlwan Ahmad , Dardiri Masyhudan
Published: June 2022

Capital is one of the problems faced by micro traders. The presence of BMT is a solution for those who need capital assistance to develop a business, so it needs a direct role from BMT. This study aims to determine the financing mechanism in BMT UGT Sidogiri Cabang Jombang and to know the role of BMT UGT Sidogiri Cabang Jombang in empowering micro traders. The research method used is descriptive analysis method. Data collection techniques used are observation, interviews, and documentation. The results of this study indicate that 1) the financing mechanism in BMT UGT Sidogiri Cabang Jombang is very easy and fast by going through several stages, namely the applicant proposes financing by meeting the requirements, then analysis and survey will be carried out. After submission in acc, the next stage is he contract process and the disbursement process. 2) The role of BMT UGT Sidogiri Cabang Jombang in empowering micro traders is by providing capital assistance through financing. In addition to financing, BMT UGT Sidogiri Cabang Jombang also provides financing but has not been maximized, namely only as an initiative in the form of providing motivations to traders.
Analisis Kelayakan Pembiayaan Mudharabah di BMT Bina Ummat Sejahtera Cabang Cukir
Authors: May Nor Azita  , Ajib Ridlwan Ahmad , Hidayati Athi
Published: June 2022

This research is motivated by the large number of prospective members applying for financing at the Cukir Branch of BMT BUS, one of which is mudharabah financing. Of course, of the many who proposed this financing, there are some obstacles, there are financing that is not easy, doubtful and stuck or said to be with financing problems. The purpose of this research is to identify the procedure for providing mudharabah financing as well as the feasibility of mudharabah financing along with the implementation of the 5C principle which is carried out at the Cukir Branch Branch Bus BMT. This research uses qualitative research using primary information taken using observations and interviews which are used to obtain information on mudharabah financing at the BMT Bus Cukir Branch and for secondary information research documentation: library research, Internet library books and overwriting the profile of BMT Bis. The research results show that in carrying out the mudharabah financing procedure at the BMT Bus Cukir Branch, it is very correct to carry out the 5C principle carefully to prospective members and likewise the feasibility of mudharabah financing to practice the 5C principle but for prospective members who have long and honestly met the needs of the BMT Bus Branch Cukir only analyzes using Capacity, Capital and Collateral.
PERAN BANK WAKAF MIKRO DALAM MENINGKATKAN KESEJAHTERAAN MASYARAKAT (STUDI KASUS BWM TEBUIRENG MITRA SEJAHTERA)
Authors: M. Daim Faisal Bagus Aji Apriliawan , Ajib Ridlwan Ahmad , Haryanti Peni
Published: June 2022

Micro waqf banks are predicted to be a solution in improving the welfare of the poor and micro business actors around Islamic boarding schools, where this micro waqf bank is presented in accordance with Islamic values. The purpose of this study was to determine the management of the BWM Tebuireng Mitra Sejahtera fund and its role in improving the welfare of the pesantren environment. This research approach is to use a qualitative descriptive approach based on observations, interviews, or document review. This research also shows that BWM Tebuireng Mitra Sejahtera has a role in improving people's welfare. This has been proven through the ability of the community to implement Maqoshid Sharia in the form of religious protection (Hifdzu Ad-Din), protection of the soul (Hifdzu An-Nafs), protection of reason (Hifdzu Akl), protection of descendants (Hifdzu An-Nashl) protection of property (Hifdzu Maal).
Analisis Persepsi Pedagang Muslim Dalam Memilih Produk Lembaga Keuangan Syariah (Studi Kasus Pedagang Muslim Kawasan Makam Gusdur Tebuireng Jombang)
Authors: Zamroni Azhar Andi , Yasin Ach , Hidayati Athi`
Published: June 2022

Lembaga Keuangan Syariah ialah lembaga beserta usaha pokok memberikan pembiayaan dan jasa dalam lalu lintas pembayaran dan peredaran uang dengan prinsip pokok syariah, untuk menolong umat muslim dari riba, namun masih banyak pedagang muslim yang belum menggunakan jasa lembaga keuangan syariah. Maksud reset  ini yaitu untuk mengenal persepsi dan motivasi pedagang muslim dalam memilih produk-produk lembaga keuangan syariah. Pendekatan penelitian ini memakai kualitatif. pengumpulan data dengan wawancara. populasi penelitian ini adalah para pedagang yang ada di Jombang. Hasil Penelitian menunjukkan para pedagang bersepsi bahwa LKS khususnya pada BMT memiliki kontribusi yang sangat besar bagi pemberdayaan maupun pengembangan usaha kecil, tetapi pedagang berkeluh kesah tentang prosedur dalam peminjaman di LKS.

Kata Kunci : Persepsi, Lembaga Keuangan Syariah
Reaksi Pasar Saham Jakarta Islamic Index Sebelum dan Sesudah Pengumuman Kabinet Indonesia Maju
Authors: Seno Aji Tony , Fitriana Arinta
Published: June 2022

The purpose of this study was to determine the significant differences in the TVA(trading volume activity) and AR(abnormal return) on the JII stock for the observation period before and after the announcement of Indonesia Maju Cabinet 2019. The data in this study were secondary data obtained from Indonesia Stock Exchange(IDX) and Yahoo Finance with event windows of 2 days before and 2 days after the announcement. Data processing in this study used paired sample t test and Wilcoxon signed rank test with the Shapiro Wilk test as a requirement to determine the normality point of the data distribution. The study results indicated that there were a disvergence in TVA and there was no significant disvergence in AR before and after the announcement of Indonesia Maju Cabinet 2019 which represents the market reaction to the event when viewed from trading activity and stock prices.
 Keywords: Trading Volume Activity, Abnormal Return, Jakarta Islamic Index
Problematika Moral Hazard pada Pembiayaan Mudharabah di BMT Maslahah Cabang Ngoro Kabupaten Mojokerto
Authors: Agustianto Mochammad Andre , Alfafa Muhimmatin
Published: June 2022

Penelitian ini merupakan penelitian kualitatif yang berupaya untuk menyingkap problematika penyebab terjadinya Moral Hazard pada transaksi pembiayaan Mudharabah yang terjadi pada BMT Maslahah Cabang Ngoro Kabupaten Mojokerto dan strategi mitigasi risiko yang dilakukan. Penelitian ini merupakan penelitian Studi Kasus yang disajikan secara deskriptif kualitatif dengan menjadikan BMT Maslahah Cabang Ngoro Kabupaten Jombang sebagai objek penelitian.  Hasil penelitian mengungkapkan terdapat dua faktor penyebab terjadinya moral hazard, faktor internal dan faktor eksternal. Adapun strategi mitigasi risiko yang dilakukan adalah dengan cara Early Warning Sytem Before Transaction berupa pengetatan analisis kelayakan calon anggota dan pengawasan melekat secara On Site Monitoring.
 Kata kunci: Moral Hazard; Mitigasi Risiko;BMT Maslahah
A Composite of Cubic Calcium-Magnesium Sulfate and Bioglass for Bone Repair
Authors: Chen Yan , Zhang Tie , Zhang Qi , Lei QingJian , Gao ShiJie , Xiao KangWen , Yan FeiFei , Cai Lin
Published: June 2022

Calcium sulfate (CS) bone cement has been shown to have good biocompatibility and can be used as a bone filler for repairing bone defects. However, its clinical application is limited due to its low compressive strength and weak bone repair activity. To this end, in this study, cubic crystalline magnesium-doped calcium sulfate (MgCS) was prepared and mixed with 45S5 bioglass (BG) to form a composite bone cement (MgCS/BG). The results show that cubic crystal calcium sulfate helps to increase the compressive strength of the composite bone cement to more than 60 MPa. More importantly, the obtained magnesium-doped composite bone cement can promote the adhesion and differentiation of mesenchymal stem cells and has good bioactivity. Through a skull defect model, it was found that MgCS/BG can significantly enhance bone defect repair and new bone formation. This new composite MgCS/BG is very promising for future translation into clinical applications.
Prevalence of Kudoa thyrsites (Myxozoa, Multivalvulida) in Atlantic Mackerel, Scomber scombrus L., in the Vicinity of the Faroe Islands
Authors: Højgaard Dánjal Petur , í Homrum Eydna , Salter Ian
Published: June 2022

Atlantic mackerel Scomber scombrus is an important migratory fish in Faroese waters and the Northeast Atlantic at large. Similar to other fish species from marine environments, mackerel can be infected by the myxozoan parasite Kudoa thyrsites, leading to myoliquefaction that renders the fish commercially unviable. Despite the ecological and economic significance of K. thyrsites as a parasite, little is known regarding its prevalence in the Faroese mackerel fishery. Prior to analysing field samples, we examined 104 samples of Atlantic mackerel selected from a Faroese processing plant on the basis of visible soft-tissue. Using microscope smears we observed K. thyrsites in 98% of the soft-tissue mackerel specimens and a direct comparison with qPCR demonstrated strong agreement between the two techniques (Φ = 0.429, p<0.01; Fisher’s exact test). We used qPCR to analyze a total of 594 Atlantic mackerel specimens, collected from Faroese fishing grounds during 2017 and 2018. Overall prevalence was 4.1% (95% confidence interval; 2.5-5.7%) and ranged from 0-14% at different locations. Infection by K. thyrsites was documented in fish as young as 2 years (195g) and up to 14 years (615g) of age. A logistic regression model indicated the odds of infection were statistically associated with sampling location and month, but not gender, age, weight or length, although a Chi-squared test on age categories showed the oldest fish (>10 years) had highest prevalence (10.8%, CI: 4.2-17.5%). In order to investigate potential infection pathways we performed qPCR analysis on eDNA in water samples collected from the Faroese Plateau. However, we found no molecular evidence for K. thyrsites spores in Faroese plankton assemblages. Our data support the prevailing hypothesis that both the alternating invertebrate host and infection of Atlantic mackerel by K. thyrsites occurs in more southern waters.
Automated High-Definition MRI Processing Routine Robustly Detects Longitudinal Morphometry Changes in Alzheimer’s Disease Patients
Authors: Rechberger Simon , Li Yong , Kopetzky Sebastian J. , Butz-Ostendorf Markus ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: June 2022

Longitudinal MRI studies are of increasing importance to document the time course of neurodegenerative diseases as well as neuroprotective effects of a drug candidate in clinical trials. However, manual longitudinal image assessments are time consuming and conventional assessment routines often deliver unsatisfying study outcomes. Here, we propose a profound analysis pipeline that consists of the following coordinated steps: (1) an automated and highly precise image processing stream including voxel and surface based morphometry using latest highly detailed brain atlases such as the HCP MMP 1.0 atlas with 360 cortical ROIs; (2) a profound statistical assessment using a multiplicative model of annual percent change (APC); and (3) a multiple testing correction adopted from genome-wide association studies that is optimally suited for longitudinal neuroimaging studies. We tested this analysis pipeline with 25 Alzheimer’s disease patients against 25 age-matched cognitively normal subjects with a baseline and a 1-year follow-up conventional MRI scan from the ADNI-3 study. Even in this small cohort, we were able to report 22 significant measurements after multiple testing correction from SBM (including cortical volume, area and thickness) complementing only three statistically significant volume changes (left/right hippocampus and left amygdala) found by VBM. A 1-year decrease in brain morphometry coincided with an increasing clinical disability and cognitive decline in patients measured by MMSE, CDR GLOBAL, FAQ TOTAL and NPI TOTAL scores. This work shows that highly precise image assessments, APC computation and an adequate multiple testing correction can produce a significant study outcome even for small study sizes. With this, automated MRI processing is now available and reliable for routine use and clinical trials.
Improving the Robustness of Human-Machine Interactive Control for Myoelectric Prosthetic Hand During Arm Position Changing
Authors: Ke Ang , Huang Jian , Wang Jing , He Jiping
Published: June 2022

Robust classification of natural hand grasp type based on electromyography (EMG) still has some shortcomings in the practical prosthetic hand control, owing to the influence of dynamic arm position changing during hand actions. This study provided a framework for robust hand grasp type classification during dynamic arm position changes, improving both the “hardware” and “algorithm” components. In the hardware aspect, co-located synchronous EMG and force myography (FMG) signals are adopted as the multi-modal strategy. In the algorithm aspect, a sequential decision algorithm is proposed by combining the RNN-based deep learning model with a knowledge-based post-processing model. Experimental results showed that the classification accuracy of multi-modal EMG-FMG signals was increased by more than 10% compared with the EMG-only signal. Moreover, the classification accuracy of the proposed sequential decision algorithm improved the accuracy by more than 4% compared with other baseline models when using both EMG and FMG signals.
Case Report: Clinical Outcome From Pallidal Stimulation in a Patient With Levodopa-Resistant Dopa-Responsive Dystonia
Authors: Wang Xue , Mei Shanshan , Tian Zichen , Wang Lin , Hao Guiliang , Zhu Xin , Mao Wei , Li Jianyu
Published: June 2022

Dopa-responsive dystonia (DRD) is a group of movement disorders with genetic and clinical heterogeneity. Dramatic response to levodopa is the hallmark of DRD. Therefore, DRD cases with poor response to levodopa are rarely reported. In addition, the clinical outcomes from deep brain stimulation (DBS) in levodopa-resistant patients remain unclear. Here, we described the clinical outcome of pallidal stimulation in a DRD patient having a poor response to levodopa. The patient was a 25-year-old man and had a 7-year history of cervical dystonia. A novel frameshift mutation in the GCH1 gene was found in the patient as well as his elder sister and mother. Unfortunately, he had no response to a large dosage of levodopa/benserazide (600/150 mg per day) and onabotulinumtoxin A injection. Therefore, bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) was performed. With parameter adjustments, the severity of his torticollis was gradually improved and relieved substantially in the 8-month follow-up visit. Our current report highlights that GPi-DBS therapy leads to promising clinical outcomes for levodopa-resistant DRD.
Utilization of Drivers’ Dynamic Visual Characteristics to Find the Appropriate Information Quantity of Traffic Engineering Facilities on Straight Roads of Grassland Highways
Authors: Li Hangtian , Xie Songfang , Yang Feng , Lu Yang , Zhu Shoulin
Published: June 2022

To find the appropriate range of information quantity, we studied how the information quantity of traffic engineering facilities (TEFs) on straight roads of grassland highways affects a driver’s eye movements. We used a combination of survey, statistics, analysis of variance, and the establishment of virtual scene to do this research, and carried out simulated driving tests at six levels (Z0, Z1, Z2, Z3, Z4, and Z5) of TEF information quantity. The driver’s fixation duration, visual search breadth, and glance speed were evaluated in a quantitative way. Results showed that the information quantity had a significant impact on eye movements. It is concluded that the information quantity from 0 to 10 bits/km may cause problems to drivers, whereas the information quantity of 40 bits/km serves as the limit. The information quantity from 30 to 40 bits/km is the appropriate one for TEF on grassland highways.
Dietary Magnesium Intake Level Modifies the Association Between Vitamin D and Insulin Resistance: A Large Cross-Sectional Analysis of American Adults
Authors: Liu Ya , Gong Rongpeng , Ma Haixiu , Chen Siai , Sun Jingwei , Qi Jiarui , Pang Yidan , An Juan , Su Zhanhai
Published: June 2022

Background

Previous clinical studies and randomized controlled trials have revealed that low serum vitamin D levels are associated with the risk of developing insulin resistance. Magnesium has been reported to be a protective factor for insulin resistance, and magnesium has been considered an important co-factor for vitamin D activation. However, the effect of dietary magnesium intake on the relationship between vitamin D and the risk of developing insulin resistance has not been comprehensively investigated. Therefore, we designed this cross-sectional analysis to assess whether dietary magnesium intake modifies the association of vitamin D and insulin resistance.

Methods

A total of 4,878 participants (male: 48.2%) from 4 consecutive cycles of the National Health and Nutrition Examination Survey (2007–2014) were included in this study after a rigorous screening process. Participants were stratified by their dietary magnesium intake into low-intake (<267 mg/day) and high-intake (≥267 mg/day) groups. We assessed differences between serum vitamin D levels and the risk of developing insulin resistance (interaction test), using a weighted multivariate logistic regression to analyze differences between participants with low and high magnesium intake levels.

Results

There was a negative association between vitamin D and insulin resistance in the US adult population [OR: 0.93 (0.88–0.98)], P < 0.001. Dietary magnesium intake strengthened the association (P for interaction < 0.001). In the low dietary magnesium intake group, vitamin D was negatively associated with the insulin resistance [OR: 0.94 (0.90–0.98)]; in the high dietary magnesium intake group, vitamin D was negatively associated with insulin resistance [OR: 0.92 (0.88–0.96)].

Conclusion

Among adults in the United States, we found an independent association between vitamin D level and insulin resistance, and this association was modified according to different levels of magnesium intake.
Values of MRI Imaging Presentations in the Hepatobiliary Phase, DWI and T2WI Sequences in Predicting Pathological Grades of Intrahepatic Mass-Forming Cholangiocarcinoma
Authors: Xing Li-Hong , Zhuo Li-Yong , Wang Jia-Ning , Zhang Yan , Zhu Feng-Ying , Wang Chu , Yin Xiao-Ping , Gao Bu-Lang
Published: June 2022

Objective

To retrospectively investigate the value of various MRI image menifestations in the hepatobiliary phase (HBP), DWI and T2WI sequences in predicting the pathological grades of intrahepatic mass-forming cholangiocarcinoma (IMCC).

Materials and Methods

Forty-three patients of IMCCs confirmed by pathology were enrolled including 25 cases in well- or moderately-differentiated group and 18 cases in poorly-differentiated group. All patients underwent DWI, T2WI and HBP scan. The Chi square test was used to compare the differences in the general information. Logistic regression analysis was used to analyze the risk factors in predicting the pathological grade of IMCCs.

Results

The maximal diameter of the IMCC lesion was < 3 cm in 11 patients, between 3 cm and 6 cm in 15, and > 6 cm in 17. Sixteen cases had intrahepatic metastasis, including 5 in the well- or moderately-differentiated group and 11 in the poorly-differentiated group. Seventeen (39.5%) patients presented with target signs in the DWI sequence, including 9 in the well- or moderately-differentiated group and 8 in the poorly-differentiated group. Twenty (46.5%) patients presented with target signs in the T2WI sequence, including 8 in the well- or moderately-differentiated group and 12 in the poorly-differentiated group. Nineteen cases (54.3%) had a complete hypointense signal ring, including 13 in the well- or moderately-differentiated group and 6 in the poorly-differentiated group. Sixteen (45.7%) cases had an incomplete hypointense signal ring, including 5 in the well- or moderately-differentiated group and 11 in the poorly-differentiated group. The lesion size, intrahepatic metastasis, T2WI signal, and integrity of a hypointense signal ring in HBP were statistically significantly different between two gourps. T2WI signal, presence or non-presence of intrahepatic metastasis, and integrity of hypointense signal ring were the independent influencing factors for pathological grade of IMCC.

Conclusion

Target sign in T2WI sequence, presence of intrahepatic metastasis and an incomplete hypointense-signal ring in HBP are more likely to be present in poorly-differentiated IMCCs.
Adjuvant Chemotherapy Benefit in Elderly Stage II/III Colon Cancer Patients
Authors: Chen Xin , Tu Junhao , Xu Xiaolan , Gu Wen , Qin Lei , Qian Haixin , Jia Zhenyu , Ma Chuntao , Xu Yinkai
Published: June 2022

Background

Studies providing more evidence to guide adjuvant chemotherapy decisions in elderly colon cancer patients are expected.

Methods

We obtained data from the Surveillance, Epidemiology and End Results (SEER) database between 2004 and 2012. Kaplan-Meier survival curves were constructed to calculate the cancer-specific survival (CSS) rate, and comparisons of survival difference between different subgroups were performed using the log-rank test. Multivariate Cox proportional hazards regression models were carried out to estimate hazard ratio (HR) and 95% confidence intervals (CIs) of different clinicopathological characteristics.

Results

In stage II colon cancer patients aged 70 years or older, the Kaplan-Meier survival analysis showed that the 5-year CSS rates of no chemotherapy and chemotherapy groups were 82.0% and 72.4%, respectively (P < 0.001). In stage III colon cancer patients aged 70 years or older, the Kaplan-Meier survival analysis showed that the 5-year CSS rates of no chemotherapy and chemotherapy groups were 50.7% and 61.3%, respectively (P < 0.001). Patients with chemotherapy receipt were independently associated with a 35.8% lower cancer-specific mortality rate (HR = 0.642, 95% CI: 0.620-0.665, P < 0.001) compared with those who did not receive chemotherapy.

Conclusions

Adjuvant chemotherapy should be considered during the treatment of stage III colon cancer patients aged 70 years or older, but the chemotherapy benefit in elderly stage II colon cancer is suboptimal.
A Novel IL3-ETV6 Fusion in Chronic Eosinophilic Leukemia Not Otherwise Specified With t(5; 12) (q31; p13): A Case Report and Literature Review
Authors: Zhao Cenzhu , Wang Man , Zhan Yuchen , Xu Yang , Chen Suning , Wang Qinrong , An Jingnan , Liu Tianhui
Published: June 2022

Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) is classified as Myeloproliterative Neoplasms (MPN) and refers to chronic eosinophilic leukemia with some atypical recurrent genetic evidence(1). A rare fusion of ACSL6-ETV6 was previously identified in patients with the t(5;12) (q31; p13) karyotype(2). Here, we report a case of CEL-NOS with a translocation of t(5;12) (q31; p13) and identify IL3-ETV6 transcription, which has not been identified in hematologic diseases. In this patient, eosinophilia was observed. And compared with CEL-NOS patients without ETV6 fusion, a higher mRNA expression level of IL3 was found. After failing treatment with dasatinib, the patient was given hydroxyurea (HU). Subsequently his white blood cell (WBC) and eosinophils decreased significantly and remained in the normal range until publication. Due to the side effects, treatment with HU was replaced by PEG-interferon (PEG-IFN). What’s more, we summarized the case in our study and 21 patients with the karyotype of t(5; 12) (q31; p13) reported by other groups. It was found that most of them had similar clinical manifestations of eosinophilia and tyrosine kinase inhibitor (TKI) insensitivity. The ectopic mRNA expression of IL3 may be the main cause of eosinophilia, and HU and prednisone acetate (PAT), as well as IFN, were considered treatments for this group.
Aptamer-Based Triple Serum Fluorescence Intensity Assay: A Novel and Feasible Method for the Clinical Diagnosis of Primary Hepatic Carcinoma
Authors: Zhou Jian-Ming , Han Fang-Li , Zhang Hong-Li , Sun Ying , Li Zi-Hua , Wang Ting , Zhang Kun-He
Published: June 2022

Background and Aims

Aptamers are artificial ligands that bind to biological targets with high specificity and affinity. We previously selected a group of aptamers against the serum of primary hepatic carcinoma (PHC) via systematic evolution of ligands by exponential and enrichment (SELEX) method, and some of the aptamers were valuable for PHC diagnosis in polyacrylamide gel electrophoresis (PAGE) analysis. Here, we used aptamers to develop a novel method suitable for the clinical diagnosis of PHC.

Methods

The intensities of serum autofluorescence, cell-free DNA (cfDNA)-related fluorescence and aptamer-related fluorescence, named the aptamer-based triple serum fluorescence intensity (ATSFI), were sequentially measured at 8 °C and 37 °C in one tube by using a real-time polymerase chain reaction (PCR) system as a fluorimeter in patients with PHC (n=346) or liver cirrhosis (n=321). The diagnostic performances of ATSFI indicators alone and in combination were evaluated by area under the receiver operator characteristic curve (AUROC), and the underlying clinical mechanisms were analyzed by bivariate correlation.

Results

The measurement of ATSFI was high throughput, rapid, convenient, and low cost. The aptamer-related fluorescence indicator SEA-SE37 was the most valuable for PHC diagnosis among all fluorescence indicators and superior to alpha-fetoprotein (AFP) (AUROC 0.879 vs. 0.836). The logistic model of ATSFI indicators exhibited excellent diagnostic performance for PHC, including AFP-negative, early and small PHCs, with AUROCs of 0.935-0.950 and accuracies of 86.8-88.3%. The diagnostic performance was further improved when ATSFI indicators were combined with AFP, with AUROCs of approximately 0.95 and accuracies of approximately 90%, suggesting ATSFI was independent of but complementary to AFP in PHC diagnosis. ATSFI models were highly valuable in clinical decision-making. The aptamer-related fluorescence intensity was generally independent of the clinicopathological characteristics of PHC but correlated with laboratory characteristics of PHC serum.

Conclusions

The ATSFI assay is a novel, robust and feasible method for the clinical diagnosis of PHC.
Medulloblastoma and the DNA Damage Response
Authors: McSwain Leon F. , Parwani Kiran K. , Shahab Shubin W. , Hambardzumyan Dolores , MacDonald Tobey J. , Spangle Jennifer M. , Kenney Anna Marie
Published: June 2022

Medulloblastoma (MB) is the most common malignant brain tumor in children with standard of care consisting of surgery, radiation, and chemotherapy. Recent molecular profiling led to the identification of four molecularly distinct MB subgroups – Wingless (WNT), Sonic Hedgehog (SHH), Group 3, and Group 4. Despite genomic MB characterization and subsequent tumor stratification, clinical treatment paradigms are still largely driven by histology, degree of surgical resection, and presence or absence of metastasis rather than molecular profile. Patients usually undergo resection of their tumor followed by craniospinal radiation (CSI) and a 6 month to one-year multi-agent chemotherapeutic regimen. While there is clearly a need for development of targeted agents specific to the molecular alterations of each patient, targeting proteins responsible for DNA damage repair could have a broader impact regardless of molecular subgrouping. DNA damage response (DDR) protein inhibitors have recently emerged as targeted agents with potent activity as monotherapy or in combination in different cancers. Here we discuss the molecular underpinnings of genomic instability in MB and potential avenues for exploitation through DNA damage response inhibition.
Significance of Triple Detection of p16/ki-67 Dual-Staining, Liquid-Based Cytology and HR HPV Testing in Screening of Cervical Cancer: A Retrospective Study
Authors: Yu Li , Chen Xun , Liu Xubin , Fei Lingyan , Ma Hanyu , Tian Tian , Wang Liantang , Chen Shangwu
Published: June 2022

In addition to liquid-based cytology (LBC) and HR HPV testing, p16/ki-67 dual-staining is another method for cervical cancer screening. The combination of any two methods can improve the accuracy of screening, but some cervical lesions are still missed or misdiagnosed. In this retrospective study, the significance of LBC, HR HPV testing and especially p16/ki-67 dual-staining in cervical lesion screening was evaluated with reference to histological diagnosis. At the same time, we tried to explore the value of p16/ki-67 dual-staining combined with LBC and HR HPV testing (triple detection) in improving the diagnostic specificity of CIN2+ and reducing the missed diagnosis of CIN2+ lesions. We found that p16/ki-67 dual-staining was valuable in identifying cervical CIN2+ lesions and reducing the missed diagnosis of CIN2+ in HPV negative patients. More than 96% of CIN2+ patients were positive for two or three tests of triple detection. Whole positive triple detection can effectively predict high grade cervical lesions. In conclusion, the triple detection can distinguish almost all cervical CIN2+ lesions. Our data put forward and highlight the feasibility and significance of triple detection in cervical lesion screening.
Heterogeneity Analysis of Bladder Cancer Based on DNA Methylation Molecular Profiling
Authors: Wang Shuyu , Xu Dali , Gao Bo , Yan Shuhan , Sun Yiwei , Tang Xinxing , Jiao Yanjia , Huang Shan , Zhang Shumei
Published: June 2022

Bladder cancer is a highly complex and heterogeneous malignancy. Tumor heterogeneity is a barrier to effective diagnosis and treatment of bladder cancer. Human carcinogenesis is closely related to abnormal gene expression, and DNA methylation is an important regulatory factor of gene expression. Therefore, it is of great significance for bladder cancer research to characterize tumor heterogeneity by integrating genetic and epigenetic characteristics. This study explored specific molecular subtypes based on DNA methylation status and identified subtype-specific characteristics using patient samples from the TCGA database with DNA methylation and gene expression were measured simultaneously. The results were validated using an independent cohort from GEO database. Four DNA methylation molecular subtypes of bladder cancer were obtained with different prognostic states. In addition, subtype-specific DNA methylation markers were identified using an information entropy-based algorithm to represent the unique molecular characteristics of the subtype and verified in the test set. The results of this study can provide an important reference for clinicians to make treatment decisions.
Ribonuclease A Family Member 2 Promotes the Malignant Progression of Glioma Through the PI3K/Akt Signaling Pathway
Authors: Wu Tingfeng , Chen Yongxiu , Yang Liying , Wang Xiangyu , Chen Ke'en , Xu Dianshuang
Published: June 2022

The treatment of patients with glioma still faces many difficulties. To further optimize treatment, it is necessary to identify more accurate markers as treatment targets and predict prognostic indicators. RNASE2 was identified as a differentially expressed gene (DEG) in glioma tissues using bioinformatics analysis. In glioma microarrays, 31.21% (54/173) and 68.79% (119/173) patients showed low and high RNASE2 protein expression levels, respectively. RNASE2 protein levels were considerably correlated with age, WHO grade, relapse, and death. Both mRNA and protein levels were associated with the overall survival of patients with glioma. To investigate the role of RNASE2, it was overexpressed or silenced in glioma cells. RNASE2 overexpression promoted cell proliferation, migration, and invasion. In addition, its overexpression promoted the growth of subcutaneous tumors and lung metastasis of glioma cells. Key protein levels in the PI3K/Akt signaling pathway were upregulated by RNASE2 overexpression. In contrast, RNASE2 knockdown had the opposite effects. Furthermore, LY294002 blocked the effects of RNASE2 on the cell function of glioma cells. In conclusion, RNASE2 is a novel marker associated with the diagnosis and prognosis of patients with glioma, and it promotes the malignant progression of gliomas through the PI3K/Akt signaling pathway.