bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 1 from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: April 2023

PDF - 2289K, Supplemental Figure 1. Expression of NUP98 and of NUP98 fusion oncoproteins in HEK293 cells. A, Schematic representation of the structures of human NUP98 (AAC50366) and of its chimeric oncoproteins. The GLFG repeats and the Rae1-interacting GLEBS domain are shown as black and dark grey boxes, respectively. The N-terminal portion of NUP98 is similar in the studied chimeras, spanning aa 1 to aa 469 in NUP98-HOXD13, and aa 1 to aa 514 in NLOC and NHHEX fusions. The HOXD13 (aa 252 to 335, AAC51635), LOC348801 isoform1 (aa 1 to 178, AAI26363), and HHEX (aa 140 to 270, NP_002720) C-terminal moieties are shown as coloured boxes. The homeodomain regions (HD) of HOXD13 and HHEX are indicated as a grey box within the coloured one. Also shown is the structure of NUP98-HOXD13IQN, which carries mutations of three amino acids within the homeodomain (white), impairing DNA binding. B, Western blot analysis showing the expression levels of the indicated proteins transiently expressed in HEK293 cells (T0), and after Nocodazole treatment at the indicated time points. Immunoblottings were performed with anti-NUP98 and anti-betaactin antibodies as a loading control.
Supplementary Figure Legend from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: April 2023

PDF file - 145K
Supplementary Table 1 from A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
Authors: Barsoum Ivraym B. , Smallwood Chelsea A. , Siemens D. Robert , Graham Charles H.
Published: April 2023

PDF file - 106K, Supplementary Table 1: Statistical analysis (two-way ANOVA) of results of cytolytic assays.
Supplementary Figures 1 - 4 from A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
Authors: Barsoum Ivraym B. , Smallwood Chelsea A. , Siemens D. Robert , Graham Charles H.
Published: April 2023

PDF file - 432K, Supplementary figures 1-2: HIF-1alpha-dependent up-regulation of PD-L1 expression in various tumour cell lines and co-localization of HIF-1alpha and PD-L1 in subcutaneous 4T1 tumours. Supplementary figure 3: Non-specific cytolytic activity of mouse CTLs against B16-F10 cells and total cytolytic activity (specific and non-specific) of mouse CTLs against B16-OVA cells. Supplementary figure 4: Effect of hypoxia and transfection with PD-L1 siRNA on PD-L1 protein levels in B16-OVA cells as well as effect of nitroglycerin therapy on the orthotopic growth of 4T1 tumours.
Supplementary Figure 3 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: April 2023

PDF file - 759K, The total mRNA levels of AZIN1 (left panel) and FLNB (right panel) in 69 matched pairs of ESCC and NT specimens in Cohort 1 (Paired Student's t test).
Supplementary Movie 4 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

MP4 file - 1786K, Supplementary movie S4: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after ICAT transfection.
Supplementary Movie 2 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

MP4 file - 3502K, Supplementary movie S2: time-lapse video-microscopy with a 10x magnification objective, of Mel501 cells plated on plastic 48 hr after ICAT transfection.
Supplemental Figure S1 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: April 2023

The relative ADAR1 expression level in nine ESCC cell lines, as detected by QPCR.
Supplementary Methods, Figure Legends, Tables 1 - 5 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

PDF file - 193K, Supplementary Table S1: Primers used to amplify the full-length mouse ICAT cDNA. Supplementary Table S2: Primers used to create the ICAT DQE mutant. Supplementary Table S3: Primers used for real-time quantitative PCR. Supplementary Table S4: siRNA oligonucleotides sequence. Supplementary Table S5: Endogenous level of ICAT, b-catenin, NEDD9 and Rac-GTP, cell morphology and migration speed in metastatic melanoma cell lines differ from non-metastatic cell lines.
Supplementary Figure 7 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

PDF file - 67K, (A) Heatmap representation of ICAT/CTNNBIP1 levels and unsupervised hierarchical clustering based on transcriptomic analysis of ICAT/CTNNBIP1 expression in 22 human melanoma metastases (31). (B) Significant decrease of median Distant Metastasis Free Survival (DMFS) time in cluster 1 (8 metastasis with high ICAT/CTNNBIP1 expression) compared to cluster 2 (14 metastases with intermediate to low ICAT/CTNNBIP1 expression). (C) Correlating NEDD9 mRNA expression levels with the expression ratio of b-catenin/ICAT shows a positive trend in metastatic melanoma (Jonsson et al., 2010). Note that tumors belonging to cluster 1 are in red and tumors belonging to cluster 2 are in green. *p<0.01
Supplementary Figure 3 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression
Authors: Wen Yu , Li Jiadong , Koo Jasmine , Shin Seung-Shick , Lin Yong , Jeong Byeong-Seon , Mehnert Janice M. , Chen Suzie , Cohen-Sola Karine A. , Goydos James S.
Published: April 2023

PDF file - 237KB, Supplemental Figure 3: Stable GRM1 knock-down cells lines were obtained by shRNA. 50% GRM1 protein level decrease in UACC9093-G4 cells dramatically decreased VEGF secretion, but 50% GRM1 protein level decrease in UACC903-G2 was not sufficient to decrease IL8 secretion to lower than that of untreated UACC903-G4.
Supplementary Figure 6 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

PDF file - 126K, (A) IF images of Lu1205 cells transiently transfected with pcDNA3 (Mock), CMV::ICAT WT (ICAT WT), CMV::ICAT DQE (ICAT DQE) expression vectors and treated for 24 hr with NSC23766 (Rac inhibitor) or Y27632 (Rho/ROCK inhibitor). Cells were incubated with an anti-phalloidin-FITC antibody (green) and DAPI (blue). B, Percentage of Lu1205 round cells after transfection and inhibitor treatment. The values reported are means plus-minus SEM of three independent measures. Note that overexpression of ICAT WT in the presence of Y27632 (ROCK inhibitor) increases slightly, but significantly (p=0.03), the number of round cells when compared to Y27632-treated cells. ns = non significant.
Supplementary Figure 4 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

PDF file - 234K, Stable exogenous ICAT expression increases Lu1205 and Mel501 cell lines migration.
Supplementary Figures 1 - 3 from Immunosurveillance by Antiangiogenesis: Tumor Growth Arrest by T Cell–Derived Thrombospondin-1
Authors: Schadler Keri L. , Crosby Erika J. , Zhou Alice Yao , Bhang Dong Ha , Braunstein Lior , Baek Kwan Hyuck , Crawford Danielle , Crawford Alison , Angelosanto Jill , Wherry E. John , Ryeom Sandra
Published: April 2023

PDF file - 706K, Supplemental Figure 1- TSP-1 suppresses tumor growth and is cleaved after immune activation. Supplemental Figure 2 - LCMVa infection inhibits B16F10 melanoma growth long term and does not change the number of macrophages or neutrophils in the tumor. Supplemetal Figure 3- Tumor suppression is T cell dependent.
Supplementary Figure Legends from Distinct Functions of Epidermal and Myeloid-Derived VEGF-A in Skin Tumorigenesis Mediated by HPV8
Authors: Ding Xiaolei , Lucas Tina , Marcuzzi Gian P. , Pfister Herbert , Eming Sabine A.
Published: April 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S3.
Data Supplement from Heparanase Cooperates with Ras to Drive Breast and Skin Tumorigenesis
Authors: Boyango Ilanit , Barash Uri , Naroditsky Inna , Li Jin-Ping , Hammond Edward , Ilan Neta , Vlodavsky Israel
Published: April 2023

Supplementary Figure 2: Over-expression of heparanase/8C in MCF10AT1 cells.
Data Supplement from Heparanase Cooperates with Ras to Drive Breast and Skin Tumorigenesis
Authors: Boyango Ilanit , Barash Uri , Naroditsky Inna , Li Jin-Ping , Hammond Edward , Ilan Neta , Vlodavsky Israel
Published: April 2023

Supplementary Figure 4: Accelerated tumor development in Hpa-Tg mice exposed to DMBA/TPA skin carcinogenesis treatment.
Supplementary Figure Legends from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: April 2023

PDF file - 144K
Supplementary Figure 8 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: April 2023

PDF file - 1486K, Figure. S8. Treatment with ASC-J9 could inhibit RCC cells migration, invasion and proliferation.
Supplementary Figure 5 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: April 2023

PDF file - 471K, Figure. S5. AR suppresses the expression of Hif-2αand VEGF via could miR-145.
Supplementary Figure 4 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: April 2023

PDF file - 271K, Figure. S4. HIF2a promoter luciferase assay also demonstrated that AR could modulate the transcription of HIF-2α in RCC cells.
Supplementary Figure 3 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: April 2023

PDF file - 1477K, Figure. S3. RCC cell proliferative ability were determined by BrdU incorporation assay.
Data Supplement from Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
Authors: Li Bin , Fei Dennis Liang , Flaveny Colin A. , Dahmane Nadia , Baubet Valérie , Wang Zhiqiang , Bai Feng , Pei Xin-Hai , Rodriguez-Blanco Jezabel , Hang Brian , Orton Darren , Han Lu , Wang Baolin , Capobianco Anthony J. , Lee Ethan , Robbins David J.
Published: April 2023

Pyrvinium attenuates SHH signaling via CK1a (Figure S1); Validation of CK1a shRNA (Figure S2); Increased CK1a activity induces Gli1 degradation (Figure S3).
Data Supplement from Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
Authors: Li Bin , Fei Dennis Liang , Flaveny Colin A. , Dahmane Nadia , Baubet Valérie , Wang Zhiqiang , Bai Feng , Pei Xin-Hai , Rodriguez-Blanco Jezabel , Hang Brian , Orton Darren , Han Lu , Wang Baolin , Capobianco Anthony J. , Lee Ethan , Robbins David J.
Published: April 2023

Legend for Supplementary Figures S1-S3.
Supplementary Table and Figure Legends from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: April 2023

Supplementary Table and Figure Legends
Supplementary Table 2 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: April 2023

Supplementary Table 2. Differentially expressed genes were identified between BRG1 mutant and BRG1 wild-type NSCLC cell lines, as described in Materials and Methods. Using an FDR threshold of .025, a total of 135 genes were down-regulated in the BRG1 mutant cell lines.
Supplementary Table S2 from RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation
Authors: Danussi Carla , Akavia Uri David , Niola Francesco , Jovic Andreja , Lasorella Anna , Pe'er Dana , Iavarone Antonio
Published: April 2023

Table S2. Drivers identified by Multi-Reg
Supplementary Figure 4 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: April 2023

Supplementary Figure 4. The figure shows kernal-smoothed data for nucleosome positioning about transcription start sites in the Brg1 KD human NSCLC cell line and in mouse SNF5 and Brg1 KO cells.
Supplementary Information from Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b
Authors: Shiah Shine-Gwo , Hsiao Jenn-Ren , Chang Wei-Min , Chen Ya-Wen , Jin Ying-Tai , Wong Tung-Yiu , Huang Jehn-Shyun , Tsai Sen-Tien , Hsu Yuan-Ming , Chou Sung-Tau , Yen Yi-Chen , Jiang Shih Sheng , Shieh Yi-Shing , Chang I-Shou , Hsiao Michael , Chang Jang-Yang
Published: April 2023

Supplementary Information. Include supplementary material, methods, table title and figure legends
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: April 2023

Supplemental Figure 1: Macroscopic analysis of metastatic mammary tumor growth
Data Supplement from A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer
Authors: Zhao Yu , Yang Yihua , Trovik Jone , Sun Kun , Zhou Liang , Jiang Peiyong , Lau Tat-San , Hoivik Erling A. , Salvesen Helga B. , Sun Hao , Wang Huating
Published: April 2023

Supplemental Tables S1-S5. Characteristics of the 45 normal tissues included in the PCDH10 expression analysis (S1); Characteristics of the 9 normal tissues included in the MALAT1 expression by ISH analysis (S2); Characteristics at primary treatment of 142 endometrial cancer patients from MoMaTEC* trial included in the MALAT1 investigation (S3); PCDH10 RNA expression from 142 prospectively collected endometrial cancer tumors, 19 metastatic lesions and 18 endometrial hyperplasia samples in relation to clinicopathologic data (S4); Oligos used for qRT-PCR, ChIP-PCR, Cloning and Bisulfate genomic sequencing (S5).
Data Supplement from A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer
Authors: Zhao Yu , Yang Yihua , Trovik Jone , Sun Kun , Zhou Liang , Jiang Peiyong , Lau Tat-San , Hoivik Erling A. , Salvesen Helga B. , Sun Hao , Wang Huating
Published: April 2023

Supplemental Methods and References. Description of additional methods and procedures used in the study. Also includes Supplemental References.
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: April 2023

Supplemental Figure 6: The IL4/IL4Ra interaction promotes colonization ability in vitro
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: April 2023

Supplemental Figure 7: Reduced IL4Ra expression results in reduced Erk and Akt activation in lung metastases
Supplementary Figure S6 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: April 2023

Supplemental Figure S6: Regression analysis of tissue-mimicking concentration-standard gel cubes.
Supplementary Figure S5 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: April 2023

Supplemental Figures S5A,B,C. Figure S5A: NIRF imaging of CT26 tumors (s.c.) and tumor to background ratios (TBR). Figure S5B: NIRF imaging of 4T1 tumors (o.t.)and TBR. Figure S5C: NIRF imaging of 4T1-derived metastases and TBR.
Data Supplement from Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells
Authors: Wang Xiao-kun , He Jie-hua , Xu Jing-hong , Ye Sheng , Wang Fang , Zhang Hui , Huang Zhen-cong , To Kenneth Kin Wah , Fu Li-wu
Published: April 2023

Supplementary Figure S4. A representative Western blot of the effect of afatinib on AKT and ERK 1/2 phosphorylation.
Data Supplement from Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells
Authors: Wang Xiao-kun , He Jie-hua , Xu Jing-hong , Ye Sheng , Wang Fang , Zhang Hui , Huang Zhen-cong , To Kenneth Kin Wah , Fu Li-wu
Published: April 2023

Supplementary figure legends
Supplemental Table 1 and Figures S1-6 from Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas
Authors: Illa-Bochaca Irineu , Ouyang Haoxu , Tang Jonathan , Sebastiano Christopher , Mao Jian-Hua , Costes Sylvain V. , Demaria Sandra , Barcellos-Hoff Mary Helen
Published: April 2023

Supplemental Table 1 and Figures S1-6. Table S1: tumor features. Fig. S1. Tumor growth curves from different irradiation group. Fig. S2. Host irradiation promotes ER-negative tumor growth. Fig. S3. Unsupervised hierarchical clustering of mouse tumors based on SD of 1.0. Fig. S4. Highly expressed genes in mammary stem cell are preferentially underexpressed in K18 compared to K14/18 tumor. Fig. S5. K14/18-IHPsi is negatively associated with MaSC signature. Fig. S6. Host irradiation exerts more robust effects on gene expression profile in ER-negative(ER-neg) than ER-positive(ER-pos) tumors.
Supplementary Figure S1 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: April 2023

Supplemental Figure S1: Specificity of TPP to Hsp70 vs Hsp60 protein
Supplementary Table 1 from A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis
Authors: Kong Ling-Min , Liao Cheng-Gong , Zhang Yang , Xu Jing , Li Yu , Huang Wan , Zhang Yi , Bian Huijie , Chen Zhi-Nan
Published: April 2023

PDF file - 75K, Oligonucleotide sequence of PCR primers and siRNA fragments.
Supplementary Figure 1 from Manganoporphyrins Increase Ascorbate-Induced Cytotoxicity by Enhancing H2O2 Generation
Authors: Rawal Malvika , Schroeder Samuel R. , Wagner Brett A. , Cushing Cameron M. , Welsh Jessemae L. , Button Anna M. , Du Juan , Sibenaller Zita A. , Buettner Garry R. , Cullen Joseph J.
Published: April 2023

PDF file - 123K, Supplementary Figure 1. AsPC-1 and Panc-1 cells treated with MnT2EPyP or MnTBAP in combination with AscH-.
Supplementary Figure 1 from A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis
Authors: Kong Ling-Min , Liao Cheng-Gong , Zhang Yang , Xu Jing , Li Yu , Huang Wan , Zhang Yi , Bian Huijie , Chen Zhi-Nan
Published: April 2023

PDF file - 30K, The effect of Sp1 and c-Myc overexpression or knockdown on CD147 expression detecting by western blot.
Supplementary Table 1 from The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
Authors: Raha Debasish , Wilson Timothy R. , Peng Jing , Peterson David , Yue Peng , Evangelista Marie , Wilson Catherine , Merchant Mark , Settleman Jeff
Published: April 2023

XLS file - 335KB, Gene expression comparison of KATO II cells and KATO II-derived DTPs.
Supplementary Figures 1 - 9 from The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
Authors: Raha Debasish , Wilson Timothy R. , Peng Jing , Peterson David , Yue Peng , Evangelista Marie , Wilson Catherine , Merchant Mark , Settleman Jeff
Published: April 2023

PDF file - 1635KB, Elevated ALDH1A1 activity in KATO II and GTL-16 DTPs (S1). ALDHhigh cells exhibit properties similar to CSCs (S2). Effect of DS on growth of parental cells and DTPs (S3). DS has opposite effects on pre- and post- KI-treated cells (S4). ALDH family members are expressed at higher level in DTPs (S5). Role of specific ALDH isoforms and cell density in drug tolerance drug (S6). Effect of the alternative ALDH inhibitor gossypol on drug-tolerant cells (S7). Increased mitochondrial respiration and ROS levels in KATO II ALDHhigh cells (S8). DS effect is not mediated by inhibition of efflux pumps or through proteasome inhibition (S9).
Data Supplement from Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer
Authors: Liu Deli , Xiong Huan , Ellis Angela E. , Northrup Nicole C. , Rodriguez Carlos O. , O'Regan Ruth M. , Dalton Stephen , Zhao Shaying
Published: April 2023

Supplementary Table S1. Canine MC case information, including histopathological description, ER status, genomic-wide studies, notable genomic changes, age, breed and sex.
Supplementary Table 1 from Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL
Authors: Richards Kristy L. , Motsinger-Reif Alison A. , Chen Hsiao-Wei , Fedoriw Yuri , Fan Cheng , Nielsen Dahlia M. , Small George W. , Thomas Rachael , Smith Chris , Dave Sandeep S. , Perou Charles M. , Breen Matthew , Borst Luke B. , Suter Steven E.
Published: April 2023

XLSX file - 116K, Canine genes that distinguish "ABC-like" and "GCB-like" subtypes (Fig. 5).
Data Supplement from Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer
Authors: Liu Deli , Xiong Huan , Ellis Angela E. , Northrup Nicole C. , Rodriguez Carlos O. , O'Regan Ruth M. , Dalton Stephen , Zhao Shaying
Published: April 2023

Supplementary Table S7. Supplementary data indicating altered genes and their function information.
Supplemental Table S2 from Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Authors: Nandhu Mohan S. , Hu Bin , Cole Susan E. , Erdreich-Epstein Anat , Rodriguez-Gil Diego J. , Viapiano Mariano S.
Published: April 2023

Sequences used for siRNA and semiquantitative RT-PCR primers.
Supplementary Table 1 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: April 2023

miRNA profiling in exosomes and cells.
Supplementary Figure 4 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: April 2023

Effect of RAB27A, RAB27B, and NSMASE2 inhibition on cellular migration and invasion. Bioinformatic analysis of mRNA target sites, AGO2 immunoprecipitation. Analysis of genomic alterations in the miR23b locus and correlation between expression and methylation of selected miRNAs (TCGA dataset).
Supplementary Figure 1 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: April 2023

NTA analysis, STR analysis, Pearson correlation values of miRNA expression in exosomes, correlation of miRNA and mRNA target abundance in cells vs. exosomes.
Supplementary Tables 1 - 6 from Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes
Authors: Hall Matthew D. , Telma Katherine A. , Chang Ki-Eun , Lee Tobie D. , Madigan James P. , Lloyd John R. , Goldlust Ian S. , Hoeschele James D. , Gottesman Michael M.
Published: April 2023

XLS file - 106KB, Use of solvent for assessing cytotoxicity of platinum complexes in the journal Molecular Cancer Therapeutics (S1). Use of solvent for assessing cytotoxicity of platinum complexes in the journal Public Library of Science (PLoS)(S2). Use of solvent for assessing cytotoxicity of platinum complexes in the journal Journal of Pharmacology and Experimental Therapeutics (JPET) (S3). Use of solvent for assessing cytotoxicity of platinum complexes in the journal Cancer Research (S4). Use of solvent for assessing cytotoxicity of platinum complexes in the journal Molecular Pharmacology (S5). Use of solvent for assessing cytotoxicity of platinum complexes (S6).
Supplementary Table 7 from Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes
Authors: Hall Matthew D. , Telma Katherine A. , Chang Ki-Eun , Lee Tobie D. , Madigan James P. , Lloyd John R. , Goldlust Ian S. , Hoeschele James D. , Gottesman Michael M.
Published: April 2023

PDF file - 65KB, Peaks observed for ESI+ mass spectra of Pt complexes dissolved in DMSO, associated with Pt-DMSO adducts.
Supplementary Figure 1 from Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes
Authors: Hall Matthew D. , Telma Katherine A. , Chang Ki-Eun , Lee Tobie D. , Madigan James P. , Lloyd John R. , Goldlust Ian S. , Hoeschele James D. , Gottesman Michael M.
Published: April 2023

PDF file - 1000KB, Scheme demonstrating the aquation of cisplatin in water, and prevention when stabilized in high chloride solution.
Supplementary Figure S1 from Sentinel Lymph Node Biopsy Revisited: Ultrasound-Guided Photoacoustic Detection of Micrometastases Using Molecularly Targeted Plasmonic Nanosensors
Authors: Luke Geoffrey P. , Myers Jeffrey N. , Emelianov Stanislav Y. , Sokolov Konstantin V.
Published: April 2023

Identification of the mouse anatomy from US images.
Supplementary Figure S4 from BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo
Authors: Shao Qiang , Kannan Aarthi , Lin Zhenyu , Stack Brendan C. , Suen James Y. , Gao Ling
Published: April 2023

Supplementary Figure S4. JQ1 suppresses MCC-2 cell proliferation; successful knockdown of p21, p27 and p57 expression in MCC cells; JQ1 increases Notch1 and NFï�«B gene expressions in MCC-3 and MCC-5 cells.
Data Supplement from Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks
Authors: Colvin Teresa A. , Gabai Vladimir L. , Gong Jianlin , Calderwood Stuart K. , Li Hu , Gummuluru Suryaram , Matchuk Olga N. , Smirnova Svetlana G. , Orlova Nina V. , Zamulaeva Irina A. , Garcia-Marcos Mikel , Li Xiaokai , Young Z.T. , Rauch Jennifer N. , Gestwicki Jason E. , Takayama Shinichi , Sherman Michael Y.
Published: April 2023

Supplemental Figure S1. Hsp70 depletion affects multiple pathways.
Supplementary Figure S5 from PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Authors: Yao Ruosi , Jiang Hao , Ma Yuhui , Wang Liping , Wang Lin , Du Juan , Hou Pingfu , Gao Yanyan , Zhao Li , Wang Guannan , Zhang Yu , Liu Dong-Xu , Huang Baiqu , Lu Jun
Published: April 2023

The subcelluar location of PRMT7 and Luciferase reporter assays of N-cadherin and Vimentin promoter activities.
Supplementary Figure S1 from PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Authors: Yao Ruosi , Jiang Hao , Ma Yuhui , Wang Liping , Wang Lin , Du Juan , Hou Pingfu , Gao Yanyan , Zhao Li , Wang Guannan , Zhang Yu , Liu Dong-Xu , Huang Baiqu , Lu Jun
Published: April 2023

Changes in mRNA levels of EMT marker genes and EMT inducers in PRMT7 overexpressing or knockdown cell lines.
Supplementary Table S3 from Complex Formation and Function of Estrogen Receptor α in Transcription Requires RIP140
Authors: Rosell Meritxell , Nevedomskaya Ekaterina , Stelloo Suzan , Nautiyal Jaya , Poliandri Ariel , Steel Jennifer H. , Wessels Lodewyk F.A. , Carroll Jason S. , Parker Malcolm G. , Zwart Wilbert
Published: April 2023

Supplementary Table S3. Motif analyses for ERα and RIP140 binding sites.
Supplementary Table S2 from Complex Formation and Function of Estrogen Receptor α in Transcription Requires RIP140
Authors: Rosell Meritxell , Nevedomskaya Ekaterina , Stelloo Suzan , Nautiyal Jaya , Poliandri Ariel , Steel Jennifer H. , Wessels Lodewyk F.A. , Carroll Jason S. , Parker Malcolm G. , Zwart Wilbert
Published: April 2023

Supplementary Table S2. Total read count and maps sequence reads for ChIP-seq datasets.
Supplementary Data from CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction
Authors: Estrach Soline , Lee Sin-Ae , Boulter Etienne , Pisano Sabrina , Errante Aurélia , Tissot Floriane S. , Cailleteau Laurence , Pons Catherine , Ginsberg Mark H. , Féral Chloé C.
Published: April 2023

Supplementary Data. Supplementary data containing supporting figure legends and mat and meth.
Supplementary Figure 1 from miR326 Maturation Is Crucial for VEGF-C–Driven Cortactin Expression and Esophageal Cancer Progression
Authors: Hong Chih-Chen , Chen Pai-Sheng , Chiou Jean , Chiu Ching-Feng , Yang Ching-Yao , Hsiao Michael , Chang Yi-Wen , Yu Yang-Hao , Hung Mien-Chie , Hsu Nai-Wen , Shiah Shine-Gwo , Hsu Nan-Yung , Su Jen-Liang
Published: April 2023

Supplementary Figure 1. The mRNA expression of Nrp1 and Nrp2 in ESCC cell lines. RT-PCR was showed the expression level of Nrp1 and Nrp2 in TE1, TE12, TE3, TE7, and TE8 cells. GAPDH was used as an internal control.
Supplementary Figure 2 from Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Authors: Xu Jinfei , Kadariya Yuwaraj , Cheung Mitchell , Pei Jianming , Talarchek Jacqueline , Sementino Eleonora , Tan Yinfei , Menges Craig W. , Cai Kathy Q. , Litwin Samuel , Peng Hongzhuang , Karar Jayashree , Rauscher Frank J. , Testa Joseph R.
Published: April 2023

PDF file - 326K, Supplementary Figure 2. A and C, H&E staining of MMs near pancreas in a WT mouse and liver in Bap1+/- mouse, respectively. B and D, Ki-67 staining showing higher proliferative index in MM from Bap1+/- mouse (D) than in tumor from WT mouse (B). E, histogram summarizing percentage of Ki-67-stained nuclei in MM tumors from WT (Bap1+/+) and Bap1+/- mice.
Data Supplement from A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets
Authors: Taguchi Ayumu , Taylor Allen D. , Rodriguez Jaime , Çeliktaş Müge , Liu Hui , Ma Xiaotu , Zhang Qing , Wong Chee-Hong , Chin Alice , Girard Luc , Behrens Carmen , Lam Wan L. , Lam Stephen , Minna John D. , Wistuba Ignacio I. , Gazdar Adi F. , Hanash Samir M.
Published: April 2023

Supplementary Table S1. X-chromosomal genes that are more than 2 fold higher in testis compared to other normal tissues in BioGPS database.
Data Supplement from Cryotherapy with Concurrent CpG Oligonucleotide Treatment Controls Local Tumor Recurrence and Modulates HER2/neu Immunity
Authors: Veenstra Jesse J. , Gibson Heather M. , Littrup Peter J. , Reyes Joyce D. , Cher Michael L. , Takashima Akira , Wei Wei-Zen
Published: April 2023

Supplementary Figure S1. (A) Untreated TUBO - tumor volume (mm3) and α-neu IgG (Ab4 equivalent μg/mL) are plotted on the left and right y-axis respectively. (B) Experimental Scheme - BALB/c females were vaccinated with pNeuE2 on day 0 and 2 (n= 4). Data representative of three independent experiments.
Supplementary Figure S11 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: April 2023

Supplementary Figure S11. A model for the functions of CtBP2 in modulating AR signaling in prostate cancer.
Supplementary Figure S1 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: April 2023

Supplementary Figure S1. CtBP2 is induced by androgen treatment.
Supplementary Video #4 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: April 2023

A single MDA-MB-231 breast cancer cell invading through the ECM towards an HMVEC vessel under shear stress (12-15 dyne cm-2).
Supplementary Video #2 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: April 2023

MDA-MB-231 breast cancer cells moving within a proteolytically degraded ECM track next to an HMVEC vessel under shear stress (12-15 dyne cm-2).
Supplemental Table and Figure Legends from Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers
Authors: Gan Gregory N. , Eagles Justin , Keysar Stephen B. , Wang Guoliang , Glogowska Magdalena J. , Altunbas Cem , Anderson Ryan T. , Le Phuong N. , Morton J. Jason , Frederick Barbara , Raben David , Wang Xiao-Jing , Jimeno Antonio
Published: April 2023

Supplemental Table and Figure Legends. Legends for Supplemental Figures S1-S6 and Supplemental Tables S1-S2.
Supplemental Figures S1-S6 from Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers
Authors: Gan Gregory N. , Eagles Justin , Keysar Stephen B. , Wang Guoliang , Glogowska Magdalena J. , Altunbas Cem , Anderson Ryan T. , Le Phuong N. , Morton J. Jason , Frederick Barbara , Raben David , Wang Xiao-Jing , Jimeno Antonio
Published: April 2023

Supplemental Figures S1-S6. Comparison of HN11 and TU167 by RNA-Seq Expression (S1); Suppression of Radiation-induced GLI1 using shRNA Model (S2); Cyst Formation Following Radiation Treatment in Orthotopic TU167-implanted Tumors (S3); Radiation-induced Gli1 Expression and the Effect of Rapamycin Inhibition in HN11 Cells (S4); Effect of siRNA inhibition on Head Neck Cancer Cells and Gli1 Nuclear Translocation (S5); Schema and Histology Detailing Radiation-induced Tumor Repopulation (S6).
Supplementary Figure Legends from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: April 2023

Supplementary Figure Legends. Supplementary Figure Legends
Supplementary Figure 4 from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: April 2023

Supplementary Figure 4. MCF-7:WS8 cells were treated with vehicle, 1nM E2, or 10nM, 100nM or 1µM concentrations of Dex, MPA, or NETA for 24 hours. PR mRNA expression was quantified by RT-PCR. 36B4 was used as an internal control. Means represent three samples in triplicate.
Supplemental Figure S1 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: April 2023

Supplemental Figure S1. Related to Figure 1: Generation and characterization of the SNAIL1-CBR mouse
Supplemental Figures 1 - 8 from Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells
Authors: Junttila Teemu T. , Li Ji , Johnston Jennifer , Hristopoulos Maria , Clark Robyn , Ellerman Diego , Wang Bu-Er , Li Yijin , Mathieu Mary , Li Guangmin , Young Judy , Luis Elizabeth , Lewis Phillips Gail , Stefanich Eric , Spiess Christoph , Polson Andrew , Irving Bryan , Scheer Justin M. , Junttila Melissa R. , Dennis Mark S. , Kelley Robert , Totpal Klara , Ebens Allen
Published: April 2023

Supplemental Fig. 1: Characteristics of T cell activation and killing induced by HER2-TDB. Supplemental Fig 2: Activation of T cells by HER2-TDB induces T cell proliferation. Supplemental Figure 3. Activity of HER2-TDB in NOD-SCID mice is dependent on human PBMCs. Supplemental Figure 4. TDB mediated killing by CD3-TG splenic T cells. Supplemental Figure 5. Effect of 4D5 on established mammary tumors in MMTV-huHER2 transgenic mice. CD3-TG T cells express both mouse and human CD3 on approximately 50% level of respective Balb/c mouse or human T cells. Supplemental Figure 6. Anti-tumor activity of HER2-TDB is T cell dependent. Supplemental Figure 7. T cells in CT26-HER2 tumors display CD69 activation marker. Supplemental Figure 8. CT-26-HER2 tumor infiltrating T cells express PD-1. CT-26-HER2 tumor cells express PD-L1.
Supplemental Figure S1 from Targeted Noninvasive Imaging of EGFR-Expressing Orthotopic Pancreatic Cancer Using Multispectral Optoacoustic Tomography
Authors: Hudson Shanice V. , Huang Justin S. , Yin Wenyuan , Albeituni Sabrin , Rush Jamie , Khanal Anil , Yan Jun , Ceresa Brian P. , Frieboes Hermann B. , McNally Lacey R.
Published: April 2023

Supplemental Figure S1. Quantification of EGF-750 probe MSOT signal accumulation within S2VP10L tumor xenografts at various time points.
Supplementary Table 1 from Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel
Authors: Nieuweboer Annemieke J.M. , Hu Shuiying , Gui Chunshan , Hagenbuch Bruno , Ghobadi Moghaddam-Helmantel Inge M. , Gibson Alice A. , de Bruijn Peter , Mathijssen Ron H.J. , Sparreboom Alex
Published: April 2023

PDF file - 77KB, Plasma pharmacokinetic parameters of paclitaxel (10 mg/kg) in mice using different formulations.
SI materials and methods from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: April 2023

additional information of materials and methods
Supplementary Figure Legends from Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel
Authors: Nieuweboer Annemieke J.M. , Hu Shuiying , Gui Chunshan , Hagenbuch Bruno , Ghobadi Moghaddam-Helmantel Inge M. , Gibson Alice A. , de Bruijn Peter , Mathijssen Ron H.J. , Sparreboom Alex
Published: April 2023

PDF file - 61KB
Supplementary Figure 5 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: April 2023

Contains Oncomine data.
Supplementary Figures 1 - 7, Table 1 from EGFR Blockade Enriches for Lung Cancer Stem–like Cells through Notch3-Dependent Signaling
Authors: Arasada Rajeswara Rao , Amann Joseph M. , Rahman Mohammad A. , Huppert Stacey S. , Carbone David P.
Published: April 2023

Supplementary Figure 1. ALDH assay time course in HCC827 cells and gating based on DEAB and DMSO controls. Supplementary Figure 2. Erlotinib treatment of H1650, EGFR mutant lung cancer cells but resistant to erlotinib. Supplementary Figure 3. Erlotinib treatment of EGFR wild type lung cancer cells increases the fraction of ALDH+ cells. Supplementary Figure 4. Related to Figure 3. EGFR mediated negative regulation of Notch3 transcriptional activity in a tyrosine kinase-dependent manner. Supplementary Figure 5 Validation of Notch1 and 3 expression upon transfection with siRNAs. Supplementary Figure 6. Validation of EGF-mediated association between EGFR and Notch 3 receptors in HCC2429 cells. Supplementary Figure 7. EGFR kinase activity is necessary for the tyrosine phosphorylation of the Notch3 receptor. Supplementary Table 1. Treatment with erlotinib increases ALDH+ cells in HCC827 cells.
Supplementary Table S1 from Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness, Proliferation, and Chemosensitivity
Authors: Chang Ching-Wen , Chen Yu-Syuan , Chou Shiu-Huey , Han Chia-Li , Chen Yu-Ju , Yang Cheng-Chieh , Huang Chih-Yang , Lo Jeng-Fan
Published: April 2023

Supplementary Table S1. Antibodies and reagents used.
Supplementary Methods from Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness, Proliferation, and Chemosensitivity
Authors: Chang Ching-Wen , Chen Yu-Syuan , Chou Shiu-Huey , Han Chia-Li , Chen Yu-Ju , Yang Cheng-Chieh , Huang Chih-Yang , Lo Jeng-Fan
Published: April 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Methods, Figure Legends from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: April 2023

Supplementary Methods, Figure Legends
Supplementary Figure 4 from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: April 2023

Supplementary Figure 4. Overexpression of miR-34a by lentiviral system in primary cells.
Supplementary Figure 2 from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: April 2023

Supplementary Figure 2. Expression levels of Notch family in tumorsphere cells.
Supplementary Video 2 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: April 2023

Live cell microscopy of MDA-MB-468 inducibly expressing empty expression plasmid and transiently transfected with H2B-GFP. The movie shows chromosome lagging.
Supplemental Figure S2 from Targeting Cancer Stem–like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma
Authors: Cornaz-Buros Sandrine , Riggi Nicolo , DeVito Claudio , Sarre Alexandre , Letovanec Igor , Provero Paolo , Stamenkovic Ivan
Published: April 2023

Supplemental Figure S2. ESFT-1 response to enoxacin in vivo.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S3. Validation of GL26-Cit cells independently transduced with gal-1-specific or control shRNA.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S4. GL26-Cit-gal1i cells do not undergo spontaneous cell-death in-vitro.
Supplementary Table S1 from Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes
Authors: Kanterman Julia , Sade-Feldman Moshe , Biton Moshe , Ish-Shalom Eliran , Lasry Audrey , Goldshtein Aviya , Hubert Ayala , Baniyash Michal
Published: April 2023

Primers for quantitative Real Time PCR.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: April 2023

Supplementary Figure 1. (A) QPCR for NPTX2 expression in an array of normal (n=4) and ccRCC (n=7) cell lines. All samples are normalized to a water negative control. Four shRNA lentiviral constructs (sh804, sh855, sh1316, sh1623) against NPTX2 were used to infect A498 cells. (B) Description of ccRCC cell line VHL mutational status. (C) QPCR for NPTX2 mRNA in each of the A498 NT vs. target lentiviral clones. (D) Western blot analysis for NPTX2 protein expression in all four A498 NPTX2 shRNA clones compared to NT control. Protein expression level quantitation is normalized to β-actin. (E) Proliferation (7 day) rescue assay of A498 cells transfected with either a human NPTX2 expression vector (+NPTX2) plasmid or empty vector (EV) control, and infected with NT control, sh1316 or sh1623 NPTX2 targeting lentivirus.