bluuebunny/crossref_metadata_2025 huggingface dataset:
Isoperistaltic versus antiperistaltic uncut Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: A propensity score matched analysis.
Authors: hangtian cui , Huabing Huang , Tianhang Luo , Xiaoyi Yin , Guoen Fang
Published: July 2020

Background
The uncut Roux-en-y anastomosis (URYA) has some clinical advantages after distal gastrectomy (DG). Little evidence exists regarding the influence of peristalsis on this anastomosis. We aimed to evaluate short-term outcomes of isoperistaltic URYA (iso-URYA) comparing with antiperistaltic URYA (anti-URYA) after DG.
Method:
Patients who underwent URYA for gastric cancer (GC) between January 2016 and December 2018 were selected from Shanghai Changhai Hospital, Navy Medical University. Short-term outcomes were compared between iso-URYA group and anti-URYA group after 1: 1 propensity score matching (PSM).
Result
A total of 612 patients were selected. 392 patients underwent iso-URYA and 220 patients underwent anti-URYA. After PSM, 183 patients for each group were included in the final analysis. No differences were found between them in terms of short-term complications,nutritional status and quality of life one year after surgery. Endoscopic examination showed that anti-URYA group had more severe gastritis (P = 0.036). In addition, the recanalization rate was significantly higher when the afferent loop was blocked by stapler.
Conclusion
The iso-URYA and anti-URYA group present similar results in short term outcomes. Ligation blocking afferent loop leads to lower recanalization rate.
Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial
Authors: Park Seonyoung , Kim Ah-Young , Cho Hyenseok , Baik Debora , Lee Hankil , Cho Sunghwa , Kang hye-young
Published: July 2020

Background
Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemotherapy (CC, 15.4 vs. 4.07 months). We conducted an economic evaluation of pralatrexate from a societal perspective.
Methods
Using a Markov model with a weekly cycle, we simulated the experience of patients with R/R PTCL receiving pralatrexate or CC for 15 years. The model consists of five health states; initial treatment, treatment pause, subsequent treatment, stem cell transplantation (SCT) success, and death. Comparative effectiveness was based on PROPEL phase II single-arm study and its matched historical control analysis. Costs included drug, drug administration, monitoring, adverse event management, and SCT costs.
Results
The incremental cost-effectiveness ratio of the base case was $39,153 per quality-adjusted life-year (QALY) gained. The results of one-way sensitivity analysis ranged from $33,949 to $51,846 per QALY gained, which remained within an implicit willingness-to-pay (WTP) threshold of anticancer drugs in Korea.
Conclusions
Pralatrexate is a cost-effective intervention with improved OS and incremental costs within the WTP limit. Pralatrexate could function as a new therapeutic option for patients suffering from life-threatening R/R PTCL.
Nutritional and Inflammatory Measures Predict Survival of Patients with Stage IV Colorectal Cancer
Authors: Takamizawa Yasuyuki , Shida Dai , Boku Narikazu , Nakamura Yuya , Ahiko Yuka , Yoshida Takefumi , Tanabe Taro , Takashima Atsuo , Kanemitsu Yukihide
Published: July 2020

Background: The present study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI) and modified Glasgow prognostic score (mGPS)) on overall survival (OS) in patients with stage IV colorectal cancer (CRC).Methods: Subjects were 996 patients with stage IV CRC who were referred to the National Cancer Center Hospital between 2001 and 2015. We retrospectively investigated correlations between OS and CONUT score, PNI, and mGPS. Multivariate analyses were performed using Cox proportional hazards regression models.Results: After adjusting for known factors (age, gender, ECOG performance status, location of primary tumor, CEA levels, histological type, M category, and prior surgical treatment), all three measures were found to be independent prognostic factors for OS in patients with stage IV CRC (CONUT score, p<0.001; PNI, p<0.001; mGPS, p<0.001). Significant differences in OS were found between low CONUT score (0/1) (n=614; 61%) and intermediate CONUT score (2/3) (n=276; 28%) (hazard ratio (HR)=1.20, p=0.031), and intermediate CONUT score and high CONUT score (≥4) (n=106; 11%) (HR=1.30, p=0.044). For mGPS, significant differences in OS were found between mGPS=0 (n=633; 64%) and mGPS=1 (n=234; 23%) (HR=1.83, p<0.001), but not between mGPS=1 and mGPS=2 (n=129; 13%) (HR=1.13, p=0.319). Patients with low PNI (<48.0) (n=443; 44%) showed a significantly lower OS rate than those with high PNI (≥48.0) (n=553; 56%) (HR=1.33, p<0.001).Conclusions: CONUT score, PNI, and mGPS were found to be independent prognostic factors for OS in patients with stage IV CRC, suggesting that nutritional and inflammatory status is a useful host-related prognostic indicator in stage IV CRC.Trial registration: retrospectively registered
Clinical, laboratory, and radiologic findings associated with mortality in COVID-19: A systematic review and meta-analysis
Authors: Rhim Hoo Jung , Park Jin Hyun , Lee Yuna , Kwon Seung Chan , Yu Min Gyu , Lee Hunju , Lee Solam , Ahn Yeon-Soon
Published: July 2020

Although there has been a surge in reports on coronavirus disease 2019 (COVID-19), the clinical signs and findings associated with fatal outcomes have rarely been studied. This systematic review and meta-analysis aimed to investigate the clinical, laboratory, and radiologic features associated with mortality in COVID-19. A comprehensive search was performed using PubMed, Embase, Web of Science, and other databases including government sources, for articles and reports published until May 1, 2020. We extracted the number of events (mortality and non-mortality) from case series and case-control and cross-sectional studies. Hazard ratios (HR) of each finding were extracted from studies with time-to-outcome analysis. In total, 23 studies met the inclusion criteria. Of them, 18 studies were case-control, cross-sectional, and case series study. Whereas, only 5 studies included time-to-outcome analysis. Male sex, age over 80 years, dyspnea, cardiovascular disease, chronic kidney disease, increased troponin I level, acute respiratory distress syndrome, acute kidney injury, and need of invasive mechanical ventilation were significantly associated with mortality. The identification of patients at higher risk of mortality has an utmost importance to achieve better treatment outcomes. The findings from our study may aid the prioritization in times of severe shortages of medical resources. Further studies analyzing diverse demographic and geographic populations are needed to generalize the findings from this study.
Treatment of Infrainguinal Arterial Occlusive Disease by Acotec Drug-coated Balloon in 435 Patients
Authors: ling rui , Cui Fengqiang , Chen Jianghao , Wang Hui , Shi Wenlong , Li Yanjie , Han Zenghui , Yu Jing , Wang Ling
Published: July 2020

Background: At present, there are many clinical trials of drug coated balloon in the treatment of lower extremity arterial occlusive diseases, but there are not many clinical data in the real world study. Here we aimed to evaluate the efficacy and safety ofAcotec drug-coated balloon (DCB) for chronic ischemic disease in lower extremity.Methods: Clinical data of 435 patientswith 564occlusive/stenotic lesions in 492lower extremities treated by DCB from April 2016 toApril2019 were retrospectively analyzed.The mean age was 63years.Rutherford stage 2, 3, 4, 5, and 6 were classified in 11, 167, 182, 109, and 23 limbs, respectively.The mean length of the targeted lesions was 179.6mm. Of all the lesions, 436 located at femoraland/or popliteal arteries, and 128 at infra-popliteal arteries. All the patients were followed up at 6-month intervals. The major evaluation endpoints included late lumen loss (LLL), target lesion restenosis, target lesion revascularization (TLR), and severe clinical events including mortality and major amputation.Results: The technique success rate was 96.1%.Stents were placed in 57 (13.1%) cases for flow-limited dissections or remnant stenosisgreater than 50% after DCB angioplasty.The mean follow-up time was 28.5 ± 12.1 months (12-48 months). The meanLLLwas 1.1 mm, 1.8mm, and 2.8 mm, respectively, 1, 2, and 3 years after operation. The rate ofrestenosis and TLRwas 17.3%and8.2%, respectively, 1 year after operation; 20.6% and 11.6%, respectively, 2 years after operation; 29.4% and 18.3%, respectively, 3 years after operation.Fourteenpatientsdiedand 25received amputation.Conclusion: AcotecDCBwas safe and effective in treating chronic ischemic diseases of lower extremities.A better clinical outcome was achieved in femoro-popliteal arteries, compared toinfrapopliteal arteries.
Cytoreductive Radiotherapy Combined with Abiraterone in Metastatic Castration-Resistance Prostate Cancer: A Single Center Experience
Authors: Liu Yang , Long Wen , Zhang Zitong , Mai Lixin , Huang Sijuan , Liu Boji , Cao Wufei , Wu Jianhua , Zhou Fangjian , Li Yonghong , He Liru
Published: July 2020

Background: To investigate the potential benefit of cytoreductive radiotherapy (cRT) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving abiraterone.Methods: From February 2014 to February 2019, 149 mCRPC patients treated with abiraterone were identified. Patients receiving cRT before abiraterone failure (AbiRT group) were matched by one-to-two propensity score to patients without cRT before abiraterone failure (non-AbiRT group).Results: The median follow-up was 23.5 months. Thirty patients (20.1%) were in the AbiRT group, whereas 119 patients (79.9%) were in the non-AbiRT group. The 2-year overall survival (OS) of patients managed by AbiRT, cRT after abiraterone failure, and no cRT was 89.5%, 72.0% and 72.0%, respectively (P = 0.001). On multivariate analysis, only AbiRT (HR, 0.17; 95%CI, 0.05–0.58; P = 0.004) and prognostic index (HR 2.71; 95% CI, 1.37–5.35; P = 0.004) were significant factors. After matching, AbiRT continued to be associated with improved OS (median OS not reached vs. 44.0 months, P = 0.009). Subgroup analysis revealed that patients aged ≤65 years (HR, 0.09; 95%CI, 0.01–0.65; P = 0.018), PSA ≤20 ng/mL (HR 0.29; 95% CI, 0.09–0.99; P = 0.048), chemotherapy-naïve upon abiraterone treatment (HR 0.20; 95% CI, 0.06–0.66; P = 0.008) and in intermediate prognosis groups (HR 0.13; 95% CI, 0.03-0.57; P = 0.007) had improved OS with AbiRT. Conclusions: cRT before resistance to abiraterone may improve survival in selected mCRPC patients: relatively young, chemotherapy-naïve, with a relatively low PSA level at the diagnosis of mCRPC.
Application of Ultrasound Artificial Intelligence in the Differential Diagnosis Between Benign and Malignant Breast Lesions of BI-RADS 4A
Authors: Niu SIHUA , Huang Jianhua , Li Jia , Liu Xueling , Wang Dan , Zhang Ruifang , Wang Yingyan , Shen Huiming , Qi Min , Xiao Yi , Guan Mengyao , Liu Haiyan , Li Diancheng , Liu Feifei , Wang Xiuming , Xiong Yu , Gao Siqi , Wang Xue , Zhu Jiaan
Published: July 2020

Background: The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is entirely based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS category. We analysed the morphological and texture characteristics of BI-RADS 4A benign and malignant lesions using AI, and the ultrasonic characteristics of BI-RADS 4A benign and malignant lesions were compared to examine the value of AI in the differential diagnosis of BI-RADS 4A benign and malignant lesions.Methods: A total of 206 lesions of BI-RADS 4A examined using ultrasonography were analysed retrospectively, including 174 benign lesions and 32 malignant lesions. All of the lesions were contoured manually, and the morphological and texture features of the lesions, such as circularity, depth-to-width ratio, number of spicules, edge roughness, edge fuzziness, margin lobules, energy, entropy, mean grey level, grey level variance, grey level similarity, internal calcification and angle between the long axis of the lesion and skin（ALS） of the ROI, were calculated using grey level gradient co-occurrence matrix analysis. The differences between benign and malignant lesions of BI-RADS 4A were analysed.Results: There were significant differences between the benign group and malignant group in margin lobules, entropy, internal calcification and ALS (P=0.013, 0.045, 0.045, 0.002, respectively). The malignant group had more margin lobules and lower entropy than the benign group, and the benign group had more internal calcification and a larger ALS than the malignant group. There were no significant differences in circularity, depth-to-width ratio, number of spicules, edge roughness, edge fuzziness, energy, mean of grey level, grey level variance, and grey level similarity between benign and malignant lesions.Conclusion: For benign and malignant lesions of BI-RADS 4A, margin lobules and internal echo uniformity are the critical points of differentiation. Some of the characteristics of atypical benign and malignant lesions are blurry or even inverted, which may lead to a deviation of the characteristics of benign and malignant lesions.
A CASE REPORT OF SUCCESSFUL TREATMENT OF STAGE IV EWING’S SARCOMA IN AN ADOLESCENT PATIENT
Authors: Kit O. I. , Yurchenko D. Yu. , Burtsev D. V. , Kuznetsov S. A. , Popovyan O. P. , Barashev A. A. , Chernogorov P. V. , Frantsiyants E. M. , Sagakyants A. B. , Kushtova L. B. , Mkrtchyan G. A. , Bespalova A. I. , Starzhetskaya M. V.
Published: July 2020

Background. Ewing’s sarcoma is one of the most common musculoskeletal cancers in children and adolescents. Extremely aggressive clinical course of Ewing’s sarcoma makes a successful treatment of this tumor difficult. Despite a comprehensive multidisciplinary approach to the treatment of this cancer, including chemotherapy, surgery and radiation therapy, rapid tumor progression, recurrence and resistance to chemotherapy are still common.

Our purpose was to present the results of a personalized approach to multidisciplinary combination treatment for musculoskeletal cancer involving polychemotherapy, 3D conformal radiation therapy and modern surgical technologies.

Description of the clinical case. A female patient presented to Rostov Research Institute of Oncology complaining of a tumor and moderate pain in soft tissues of the left iliac region, left lower extremity, and lameness when walking. After complete examination, the patient was diagnosed with Ewing’s sarcoma of the left ilium with lung metastases (Т3N0M1). The patient received 6 cycles of neoadjuvant chemotherapy according to EURO EWING 2008 protocol; tumor progression and lung metastasis were registered. Two cycles of second-line chemotherapy were performed; by the decision of the doctors’ council, the first stage of surgical treatment was performed: resection of the left ilium and the defect replacement with a temporary cement spacer. In the postoperative period, the patient underwent 8 cycles of adjuvant chemotherapy, external beam radiation therapy to the lungs (12 Gy total dose) and the primary tumor (46 iGy total dose), and 12 cycles of supporting therapy. A delayed second reconstructive stage of surgical treatment involved removal of a temporary cement spacer and implantation of an individual pelvic stability system. The patient was followed-up for 25 months after the combination treatment, had no complaints, and was able to ambulate without assistance; the motor function of the left hip joint was fully preserved. 

Conclusion. The use of non-standard high-technology approaches to surgical treatment of unfavorably localized Ewing’s Sarcoma in combination with chemo-radiation therapy allows patients with advanced tumors to achieve satisfactory results and good quality of life.
COMPARATIVE ANALYSIS OF MIGRATION ACTIVITY AND INVASIVE POTENTIAL OF CULTURED SOLID TUMOR CELLS
Authors: Danilova A. B. , Nekhaeva T. L. , Misyurin V. A. , Avdonkina N. A. , Emelyanova N. V. , Baldueva I. A.
Published: July 2020

Understanding of the sequence of events that ensure invasiveness of malignant cells is important for prognostic purposes. The study of the cellular and molecular pathways in the metastatic process lays the foundation for further progress in the treatment of cancer patients.

Purpose: a comparative analysis of in vitro migration and invasion of human solid tumor cells isolated from primary and metastatic lesions.

Material and Methods. Cell cultures of skin melanoma (SM, n=29), renal cell cancer (RCC, n=2), colorectal cancer (CRC, n=1), soft tissue and bone sarcomas (STBS, n=39) isolated from solid human tumors were studied. Cell migration and invasion were assessed using xCelligence (ACEA Bioscience Inc., USA).

Results. All solid tumor cell cultures demonstrated in vitro invasive potential (IP), which was 73.79 % for RCC; 53.16 % for SM; 43.96 % for STBS and 5.16 % for CRC. The rates of migration and invasion (SlopeInv) in STBS cells were higher than those in SM cells (39.33 and 25.3 μm/h (p<0.05), 95.32 and 59.82е-3, respectively (p<0.05). The differences in IP values depending on the origin of STBC cells (primary tumor, relapse, and metastasis) were revealed: 18.11 ± 3.05 %, 25.75 ± 5.57 %, 52.97 ± 5.64 %, respectively (p<0.05). We found a correlation between migration and invasion parameters of solid tumor cells and the expression of factors ensuring their mobility and affecting other cellular components of the tumor microenvironment, including cells of the immune system.

Conclusion. The biologically «aggressive» phenotype of SM and STBS cells is associated with the expression of the cancer-testis genes, such as PRAME, PASD1, SSX1 and with the production of HB-EGF, IGFBP, PLGF, PECAM-1, FST, SCF, IL-8. These products can be considered as new targets for therapeutic technologies aimed at influencing metastatic disease.
On the Acceleration of Time from the Perspective of Technological and Cognitive Innovativeness: A Structural-Semiologic Analysis of H. G. Wells’s The Time Machine
Authors: Zarić Miloš
Published: July 2020

The paper provides an analysis of Herbert George Wells’s novel The Time Machine (1895), specifically, of those aspects of the novel that deal with the relationship between the phenomenon of technological and cognitive innovativeness, on the one hand, and the experience of time and its perception, on the other. The concept of the acceleration of time, which is key to this study, denotes the phenomenon manifesting itself through the prism of two types of non-synchronization of “internal” or “subjective” time and “external”, collectively shared “objective time”: in the first case, “external” time is accelerated relative to “internal” time, while in the second, conversely, “internal” time is accelerated relative to “external time”. The paper offers a contextual analysis of The Time Machine, also employing a structural-semiologic approach and method, which in this case also includes the traditional functionalist method of differentiating between manifest and latent functions. The first research question the paper seeks to answer is how the idea/invention of the fictitious novum of the time machine came about, i.e. what kind of cognitive-innovative process enabled it. The other question, related to the first, is whether it is possible to “peer into” the infrastructure of the imagination of creative people, into that part that usually remains confined to the unconscious. A structural-semiologic analysis of the nature of the creativity/innovation process, which, in this study, is related to the Victorian era as the social and economic context in which The Time Machine was written, as well as to the interconnected domains of technological and cognitive innovativeness, suggests the possibility of establishing an Anthropology of Innovativeness as a new anthropological subdiscipline.
Organizational Culture in Ernst Young Serbia: From Proclaimed to Perceived Values
Authors: Dražeta Bogdan , Dražeta Lazar
Published: July 2020

In this paper, we examine the characteristics of organizational culture in Ernst Young Serbia. Employee perceptions of organizational culture were compared with the proclaimed company values. Interviews were conducted with 16 employees using the standardized questionnaire while the survey provided demographic and socio-economic profile of informants. Other research methods such as observation and participant observation were also used in the study. Based on the premise that organizational culture refers to a system of shared meaning held by members that distinguishes the organization from other organizations, we noticed a variety of employee perceptions including the collection of interpersonal relations, values, beliefs, attitudes, practices, rituals, rules and procedures. Ernst Young company defines its organizational culture in relation to the three core elements: inclusiveness, development and engagement. Proclaimed values of the company represent the desired employee behavior dimensions derived from above mentioned elements. These are: a) Integrity, respect, and teaming; b) Energy, enthusiasm, and the courage to lead; c) Building of relationships based on doing the right thing. Research has shown that the value system of the company has been successfully implemented in Serbia.
Petrićev argument o cjelovitosti u kontekstu suvremene psihologije
Authors: Janeš Luka
Published: July 2020

U radu razmatram Petrićev argument o cjelovitosti iznesen u »Pampsychiji«, najmanje istra­živanoj od četiriju knjiga Nove sveopće filozofije (Nova de universis philosophia, 1591.), u usporedbi s konceptima, metodologijom i pragmatičkim dosezima suvremene znanosti o ljudskoj psihi. Nastojao sam odrediti može li taj argument korespondirati metodološkom instrumentariju suvremene psihologije ili se radi o disjunktivnom, dakle animozitetnom odnosu. Naglasak je na Petrićevoj refleksiji glede »umocentričnosti« duše, pri čemu sam nastojao ukazati na dinamiku i dijalektičnost fenomena psihe kao temeljne odrednice Petrićeve psiho­ontologije te na važnost implementacije takve filozofijske refleksije u okvire sustava mentalnog zdravlja, kao pretpostavke cjelovitog integrativnog pristupa problematici.
Perspectiva actual sobre el uso de tecnologías de la información y la comunicación en personas con trastorno del espectro autista: Sistematización de experiencias
Authors: Gallardo Montes Carmen del Pilar , Caurcel Cara María Jesús , Rodríguez Fuentes Antonio
Published: July 2020

Este artículo sigue un enfoque cualitativo y está centrado en el método científico denominado “sistematización de experiencias”. Tuvo como objetivo analizar la influencia de las Tecnologías de la Información y la Comunicación (TIC) en la sociedad actual y cómo estas herramientas digitales influyen en el ámbito educativo. Se ha indagado en los efectos sobre personas con necesidades especiales, más concretamente para personas con Trastorno del Espectro Autista (TEA).
The evolution-similarity matrix: an evolutionary psychology perspective on cross-cultural advertising
Authors: Ivanov Lachezar , Buck Jordan , Sutherland Rory
Published: July 2020

Corrections to the article made on November 24, 2020
The standardization/adaptation debate in cross-cultural advertising is a topic on which little consensus prevails and which remains heavily discussed. Using evolutionary psychology, this paper presents a typology of advertising cues and explains their cross-cultural relevance and transportability. The paper highlights three distinct categories – human universals (evolved similarities), local adaptations (evolved differences), and local socialization (differences not due to evolution). The paper contributes to advertising theory by providing a meta-framework for the study of cross-cultural similarities and differences in the processing of advertising cues. It further assists advertising practice by delivering a framework aiding in cross-cultural advertising copy decisions. By raising the questions that the paper poses to develop the proposed typology categories, advertisers can identify which advertising cues are malleable by advertising and which are based on innate human preferences and are relatively stable. With that knowledge in hand, advertisers can decide when and to what extent to use a standardization approach versus an adaptation approach.
Determinants of capital structure: evidence from Jordanian service companies
Authors: K. Gharaibeh Omar , AL-Tahat Saqer
Published: July 2020

This paper examines capital structure determinants for service companies in Jordan between 2014 and 2018. Secondary data from 45 companies were analyzed using the panel regression approach. The results show that the independent variables, suggested as capital structure determinants, have an effect on the debt ratio made by the service companies. Size and non-debt tax shield have a positive significant effect on the debt ratio, while profitability and business risk have a negative significant impact on the debt ratio. In general, the findings support the notion that the trade-off, bankruptcy cost, agency cost and pecking order theories are crucial in explaining the capital structure of Jordanian service companies except for non-debt tax shields and tangibility factors. Jordanian service companies do not use fixed assets as collateral or companies with higher collateral value tend to borrow less debt. Although the coefficient of institutional investors is statistically insignificant, it is still negative and economically significant. This paper concludes that size, profitability, business risk, non-debt tax shields and institutional ownership factors are fundamental in terms of shaping the capital structure in Jordanian service companies.
Choosing for leaving a job: what is the most important consideration of married woman?
Authors: Made Dwi Puspitawati Ni , Wayan Gede Supartha I , Gusti Ayu Manuati Dewi I , Gede Riana I
Published: July 2020

Attitude is very crucial in determining the decision for a woman to stay in the job. This means that employees tend to have a desire to leave if they feel not attached to the company. Female employees who tend to be married have a role as an employee and family member. Married female employees will have high work engagement if they feel their work brings benefits to family life. This study aims to determine the effect of work-family enrichment on work engagement and turnover intention. The population of this research was 391 married women employees who worked at least a year in four-star hotels in Bali, Indonesia. The sample in this study is determined using a nonprobability sampling method with a saturated sample based on specified criteria, 331 questionnaires returned (response rate of 85%), but only 325 questionnaires were complete and feasible to be analyzed (usable response rate of 83%). Data were collected via questionnaire and analyzed using SEM (structural equation modeling). The results showed that married female employees were more enthusiastic about working when they could fulfill their multiple roles in work and be better family members. Their involvement in work seriously and feeling proud to be part of the company can reduce their intention to leave. This research is expected to be a consideration for management in making policies related to decreasing turnover intention.
Selection of indicators for the scenario modeling of the progressive countries’ economic development
Authors: Zgurovsky Michael , Gavrysh Oleg , Solntsev Sergiy , Kukharuk Anna , Skorobogatova Natalia
Published: July 2020

The study aims to improve methodical approach for formalizing the sustainable development models for progressive countries by suggesting the relevant representative indicators. The study is performed using the statistical approach to determine the suitability of data for further modeling using indicators of variation, taking into account the normality of the population distribution as the main criteria of the data set quality. The study highlights the results of processing measurable quantitative economic, social, and environmental indicators of different countries that may be used for identifying possible changes in the world’s sustainable development. The authors select the indicators for scenario modeling of the sustainable development of Brazil, India, China, Republic of Korea, and the USA, as well as suggest a set of relevant affecting factors. To confirm the meaningful impact of different factors, such as biological balance, conflicts intensity, corruption perception and other, a neural network is developed, and its preliminary training on the test data is conducted. The obtained results can be used to predict economic changes in the world under the influence of specific economic, social, and environmental factors.
Enterprise Resource Planning (ERP) systems success: impact of employees’ perceptions and satisfaction on expected benefits in a manufacturing setting
Authors: Cosmos Xulu Vukani , Suknunan Sachin
Published: July 2020

The benefits that Enterprise Resource Planning (ERP) systems can offer organizations are the primary reason behind their popularity. However, employees` satisfaction is one of the factors that affect ERP system benefits, while employees` expectations of such systems affect their satisfaction. The study aimed to identify and investigate how employees’ expectations of the general benefits from ERP systems influence employees` satisfaction and actual benefits derived. The study was performed in a manufacturing organization, and data collection entailed a quantitative questionnaire, targeting an entire population of 80 employees (ERP users). The study obtained a 66% response rate, and quantitative data analysis techniques were used. The study found out that users with high expectations were more dissatisfied and not benefiting from the ERP system compared to those with low expectations. Users with more experience did not find the ERP system very challenging compared to the users who had less experience. The Chi-square test of independence implied that the general expectations that users had on ERP systems did not affect their satisfaction (7.965, p = 0.241). Besides, there was a relationship between general expected benefits from an ERP system and the actual benefits of using it (19.342, p < 0.013). Furthermore, a moderate and significant relationship between actual benefits derived and user satisfaction was found (.451**, p < 0.001). The study concludes that there is a relationship between employees’ expected benefits, employees` satisfaction, and actual benefits derived from ERP systems.
Supply chain disruptions in the context of early stages of the global COVID-19 outbreak
Authors: Veselovská Lenka
Published: July 2020

The world finds itself facing unprecedented conditions as the global pandemic of the COVID-19 virus has led to fundamental changes in the global supply chains. This paper aims to assess the initial response undertaken by Central European companies in the early stages of the outbreak. The survey was conducted as a research method to collect data from a large number of companies. Since it takes time to assess long-term effects of the pandemic and related measures, various changes in supply chains are examined as the early results of the COVID-19 crisis and measures implemented by companies. The study examines how different economy sectors were changed due to this situation. The changes in operating volumes were identified as the most commonly used measures to accommodate new market developments. However, developing the new supply chain partnership was the most successful measure. This measure correlates with an increase in revenues and an increase in the number of customers. In some cases, disruptions in supply chains had positive effects on revenues as a reaction to the COVID-19 epidemic outbreak. Cross-country examinations found that all Polish companies implemented at least one new measure to tackle this crisis. Nearly 20% of Slovak companies and nearly 30% of Czech companies made no changes in their operations during the early stages of the crisis. However, overall, the supply chains in Central European countries turned out to be quite resilient, since most companies managed to survive the supply chain disruptions and in some cases even show signs of overcoming them completely.
Acknowledgement This contribution was supported by the project No. 1/0757/18, “Consumer behavior in buying goods of daily consumption with an emphasis placed different contents of goods offered on markets of selected EU countries”.
Az ageizmus kialakulására ható tényezők a magyar fiatalok és idősek körében
Authors: Kolos Krisztina , Kenesei Zsófia , Kiss Kornélia , Kovács Edina , Michalkó Gábor , Pinka-Sziva Ivett
Published: July 2020

Az élettel való elégedettség egyik fontos alakítója, hogy az egyes generációk milyen attitűdöt mutatnak más generációk irányában. Az utóbbi időben kedvezőtlen tendenciák érezhetők ebben a tekintetben; az egyes generációk hajlamosak a negatív attitűdök, előítéletek kialakítására, a sztereotip gondolkodásra vagy diszkriminációra. Ezt a jelenséget a szakirodalom „ageism”-nek nevezi. Kutatásunkban azt vizsgáltuk, hogy Magyarországon mennyiben jelenik meg a kor-alapú sztereotip gondolkodás, előítélet vagy diszkrimináció akár a fiatalok, akár az idősebbek körében, ezeket mennyiben befolyásolják demográfiai és viselkedésbeli változók. Az adatfelvételre 2018 decemberében került sor kérdőíves megkérdezés keretében. Eredményeink szerint a fiatalabb és az idősebb felnőttek eltérően gondolkodnak egymásról, de mindkét korosztály esetében a másik csoporttal való kapcsolatok minősége csökkentheti a sztereotip gondolkodást, előítéletet vagy diszkriminációt. A különböző érintetteknek, döntéshozóknak törekedniük kellene arra, hogy az egyes generációk pozitív tapasztalatokat szerezhessenek a korcsoportjukon kívüli emberekkel is.
HARMONIZING THE CLASH OF SUFISM AND SHARIA IN AL GHAZALI’S THOUGH
Authors: Ahmad Supriyadi
Published: July 2020

Al-Ghazali is an expert and great Muslim scholar who speaks up for moderate Sunni sufism, a sufism which is based on the doctrine of the asceticism of the Qur'an, Prophetic traditions, and the tradition of his companions. He succeeded in purifying Sufism from various deviations, and harmonizing Sufism with sharia, and making it "halal" for Sunnis. According to al-Ghazali, several terms in Sufism should be returned to the original teachings of the Qur'an and Prophetic traditions. In his view, ma'rifah is knowing the secrets of God and His various rules about everything that exists. Heart becomes a means of understanding for a Sufi. So the highest and most noble pleasure is recognizing Allah Almighty, known as ma'rifah. A wise person (‘arif) does not see other than Allah, and everything he or she knows in this existance is only Him and His various creations. In the knowledge of Mukasyafah for example, al-Ghazali wanted to avoid the mistakes of other Sufis who transgressed, such as Abu Yazid al-Bustami and Abu Manshur al-Hallaj with their philosophical concepts which tended to be very complicated.
MODERNIZATION AND COMMERCIALIZATION OF RELIGIOUS TOURISM ON REDUCTION OF PIWULANG VALUES SUNAN DRAJAT LAMONGAN (CRITICAL STUDY OF THE WEAKENING OF THE TEACHINGS AND CULTURAL VALUES OF SUNAN DRAJAT LAMONGAN)
Authors: Ulum Miftachul
Published: July 2020

Calling Sunan Drajat already familiar and his work has resonated in the archipelago. The struggle and character of the Walisongo to date remain in the hearts of the Indonesian people so that it becomes a separate tradition to always be blessed through the moment of Walisongo pilgrimage. The community is so hypnotized by the power to always appreciate good intentions through Walisongo pilgrimage moments as a form of gratitude and want to imitate Kipra and Walisongo's struggle. But with the development of the times and advances in technology, the community has been hypnotized by the presence of pilgrims. The community has used and tried to make profits only regardless of the actual conditions that religious tourism has become a magnet for mere profit. Many are forgotten and neglected from the essence of the sunan Drajat Lamongan tomb, which is a place to get closer to Allah on a pilgrimage.
CHINESE PESANTREN AND CHINA’S ACCEPTANCE TO ISLAM A STUDY ON COUNSELING SPIRIT IN CHINESE PESANTREN HU DENGZHOU JINGTANG JIAOYU
Authors: Anwar Moh Khoerul , Musyafak Nur , Musyrifin Zaen
Published: July 2020

Counseling is a psychological service provided by people who have the skills to listen well, the skills to understand others, and the skills to humanize people. These three spirits are done by one Islamic figure who teaches about Islamic culture in China to establish a pesantren (Jingtang Jiaoyu in Chinese) that has now increased. Hu Dengzhou is the early figure of Islamic education in China, and some concept developed by it is part of counseling. The idea applied is a) psychological services are given classically for people who need peace and peacefulness b) service processes are given gradually according to the assessment, if viewed from the aspect of counseling With the services provided in accordance with the results of the need assessment, c) individual counseling supplied for each student, as well as the teacher (Kyai in Indonesia) that accompanies each Student (Santri in Indonesia) so as to understand the characters, behaviors, personalities, and skills about student. The conclusion of this article is the spirit of counseling has existed since ancient times and has applied to pesantren based on Islamic culture, especially in China. Then Islam in China is not problematic because the Chinese government also recognizes that Islam is part of a culture that has existed since ancient times.
Implementation of the Methadone Maintenance Therapy Program for Highrisk Drug Prisoners
Authors: Zakaria Moch Subhan
Published: July 2020

The harm reduction program is a program that aims to assist inmates who use syringes (IDU's) in overcoming dependence on narcotics medically and to prevent the adverse effects caused by narcotics abuse. Where in general the use of heroin is done by injecting using a syringe alternately, or known as "For Wet" This can cause a new problem that is greater that the outbreak of the HIV/AIDS virus. Most prisoners use injecting narcotics before entering prison and have been infected with the HIV virus, so the risk of transmitting HIV/AIDS to other prisoners is very high. The tendency of the number of relapses (reuse) by prisoners who are in the period of coaching is quite high despite the efforts of strict supervision in the security sector, but in fact in several prisons/detention there is narcotics smuggling in various modes. For this reason, the Indonesian Ministry of Law and Human Rights through the Directorate General of Corrections organizes the P4GN program (Prevention of Eradication of Narcotics Abuse and Circulation) in prisons and detention environments by promoting the principle of "Total Abstinence" meaning that no use of any type of narcotics during coaching in prisons and prisons. But for the type of metadone, which is a type II narcotics can be tolerated because it is used for the purpose of treatment/healing of narcotics dependence and is also a government program implemented by the Ministry of Health as the leading sector.
Yaya Yollarında Kullanılan Farklı Zemin Döşeme Malzemelerinin Kullanım Performanslarının Belirlenmesi
Authors: SARIIŞIK Ali , CAN Songül
Published: July 2020

Bu çalışma, inşaat sektöründe kullanılan döşeme malzemelerinin kullanım alanlarındaki performanslarının belirlenmesi için yeni bir deney yöntemi olan bilye düşürme cihazı kullanılarak yapılan bir araştırmayı kapsamaktadır. Deneysel çalışmalarda zemin döşemesinde yaygın olarak kullanılan 4 farklı doğal taş, beton ve asfalt malzemeleri tercih edilmiştir. Bu çalışma üç bölümden oluşmaktadır: (1) bilye düşürme test cihazı kullanılarak malzemelerin, kopma enerjisi ve çarpma dayanımı değerlerinin belirlenmesi; (2) Griffith teorisi ile kırılma gerilmesinin hesaplanması ve (3) verilerin istatistiksel varyans analizi (ANOVA) ve K-ortalamalar kümeleme yöntemi ile sınıflandırılmasından oluşmaktadır. Bu deneylerden elde edilen veriler yardımıyla malzemelerin kopma enerjisi, çarpma dayanımı ve kırılma gerilmesi istatistiksel K ortalamalar kümeleme yöntemi ile kırılma potansiyeli indeksi belirlenmiştir. Malzemelerin belirlenen istatistiksel analiz sonuçları dikkate alınarak, kopma enerjisi, çarpma dayanımı ve kırılma gerilmesi sınıflandırılmış, kullanım alanlarındaki performansları belirlenmiştir. Yapılan analizler sonucunda, kırılma potansiyeli açısından beton örnekleri hariç sırasıyla; asfalt, granit, kireçtaşı, mermer ve bazalt örnekleri döşeme malzemesi olarak kullanılabilir.
Analysis of the changes and driving force of the water area in the Ulungur Lake over the past 40 years
Authors: Gao Fan , He Bing , Yan Zhenglon , Xue Songsong , Li Yizhen
Published: July 2020

The inland lakes in arid regions, especially the terminal lakes, are highly sensitive to the influence of human activities and climate change. In order to analyze the evolution of the area of water in Ulungur Lake (Buluntuohai Lake, Jili Lake) and the main causes of those changes, 3S technology, satellite data preprocessing, water extraction and database construction methods are combined with consideration of climatic changes and human activity in this study. The data in this study include 11 phases of remote sensing image data, field mapping data and relevant attribute data of the study area from 1977 to 2017. The results demonstrated the following. (1) Over the past 40 years, the change in Ulungur Lake's area was characterized by natural expansion, fluctuation stability, and recovery increase. Significant changes were mainly concentrated in the waters of Zhonghaizi, Xiaohaizi, Camel's Neck, and the waters near Akekule. (2) The period from 1977 to 1995 was the expansion period of the lake water area, and human activities were the main driving factors. The period from 2000–2017 was a smaller period of expansion of the lake water area, with warmer and more humid climate trends combined with human activities driving the change. (3) The water area that was extracted based on the MNDWI water index method can increase the contrast between bodies of water and buildings, which can aid in interpreting and extracting water element information from flat terrain and single types of surface features. This can provide an effective technical means for quantitative and dynamic analysis of the temporal and spatial changes in lake water area.
Comparative analysis of air scouring and unidirectional flushing of water distribution systems
Authors: Pourcel Florent , Duchesne Sophie
Published: July 2020

Unidirectional flushing is a widely used method to remove sedimented particles from water distribution systems and prevent water discolouration events. However, it shows low efficiency in cases of high pressure losses, usually requires large volumes of water, and does not remove incrustations. Air scouring is known for being very effective in particle removal with minimal impacts from pressure loss, requiring little water and improving hydraulic capacities by removing soft incrustations. Flushing sequences of unidirectional flushing and air scouring were performed in similar conditions on 18 pipe sections from four water distribution networks located in the province of Quebec, Canada; unidirectional flushing was also performed on 14 additional pipe sections located in three other water distribution networks. Total suspended solid concentration of flushed water, water flow and pressure were recorded to estimate the amount of flushed particles, the required water volume and the evolution of hydraulic capacities. Within the studied networks, the water requirements for air scouring were approximately 8-fold less than for unidirectional flushing and did not significantly improve the hydraulic capacity of the cleaned pipes.
Chronic “graft versus host” disease after allogeneic hematopoietic stem cell transplantation: basic characteristics, pathogenetic mechanisms, treatment strategies and problems of clinical practice
Authors: Machneva E. B. , Panarina V. Yu. , Aliev T. Z. , Shevtsov D. V. , Suleymanova A. M. , Konstantinova V. V. , Burya A. E. , Stepanyan N. G. , Skvortsova Yu. V. , Sidorova N. V. , Osmanov E. A. , Kirgizov K. I. , Varfolomeeva S. R.
Published: July 2020

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for different spectrum of diseases. This type of treatment is constantly improving, but HSCT remains a risky procedure with various possible complications, the main is – chronic “graft versus host” disease (cGVHD). сGVHD is immune disregulation, and characterized by a variety of clinical manifestations that reflect the multiple underlying pathophysiology mechanisms. The study of cGVHD has now made great progress, but there’s still a lot of questions. General characteristics, risk-factors of development, clinical manifestations, pathogenesis of cGVHD will be discussed in this article. Clinical case presented in this article explains usage of basic and novel agents for cGVHD treatment, prevention criterions for treatment of cGVHD in children.
Current algorithms for the treatment of chronic coronary total occlusions
Authors: Krestyaninov O. , Khelimskii D. , Badoian A. , Ibragimov R. , Naydenov R.
Published: July 2020

Chronic coronary total occlusions (CTOs) represent the most complex group of lesions in interventional cardiology, and technical success in their treatment depends on not only the characteristics of the lesions themselves but also the experience of the operator.Over the past few years, many CTO recanalisation techniques have been proposed, leading to the need for standardisation to achieve a higher success rate. As a result, a number of algorithms that allow the surgeon to choose one or another recanalisation technique depending on the angiographic features of the vessel have been proposed.This article provides an overview of the main algorithms for choosing a CTO recanalisation strategy and considers the clinical and angiographic characteristics that form the basis of the algorithms. The possibility of their use in clinical practice has also been evaluated.Received 7 April 2020. Revised 27 April 2020. Accepted 27 April 2020.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.Author contributionsConception and design: O.V. Krestyaninov, D.A. KhelimskiiDrafting the article: O.V. Krestyaninov, D.A. Khelimskii, A.G. Badoian, R.A. Naydenov, R.U. IbragimovCritical revision of the article: R.A. Naydenov, R.U. IbragimovFinal approval of the version to be published: O.V. Krestyaninov, D.A. Khelimskii, A.G. Badoian, R.A. Naydenov, R.U. Ibragimov