bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: SYNTHESES OF (RS)‐HOMOIBOTENIC ACID AND (RS)‐4‐BROMOHOMOIBOTENIC ACID. AN UNUSUAL MICHAEL TYPE REACTION AND ISOXAZOLE DEPROTECTION
Authors: HANSEN J. J. , KROGSGAARD‐LARSEN P.
Published: April 2016

Der Isoxazolaldehyd (I) kondensiert mit Malonsäure in 55%iger Ausbeute zur ungesättigten Carbonsäure (III), aus der man mit Ammoniak unter Addition Homoiboteninsäure (IV) erhält.
ChemInform Abstract: ELECTROPHILIC SUBSTITUTION OF 1,2‐BENZISOTHIAZOL‐3‐ACETIC ACID
Authors: UNO H. , KUROKAWA M.
Published: April 2016

Die Benzoisothiazolessigsäure (I) reagiert mit Brom zur α‐Bromcarbonsäure (II), die zur Brommethylverbindung (III) decarboxyliert werden kann und nach Finkelstein das Iodid (IV) ergibt.
ChemInform Abstract: STUDIES ON PYRIMIDINE DERIVATIVES. IX. COUPLING REACTION OF MONO‐SUBSTITUTED ACETYLENES WITH IODOPYRIMIDINES
Authors: EDO K. , SAKAMOTO T. , YAMANAKA H.
Published: April 2016

Die Umsetzung der 2‐Iodopyrimidine (I) mit Acetylenen (II) in Gegenwart des Pd‐Komplexes (III) und CuI führt zu den Alkinylpyrimidinen (IV) in sehr guten Ausbeuten.
ChemInform Abstract: TOTAL SYNTHESIS OF (RC)‐SPARSOMYCIN
Authors: HELQUIST P. , SHEKHANI M. S.
Published: April 2016

Hydroxymethylierung des Uracils (I) ergibt den Alkohol (II), der zu dem Aldehyd (III) oxidiert wird.
ChemInform Abstract: SYNTHESIS BASED ON THIONYLAMIDES. V. 2‐OXOTETRAHYDRO‐1,3‐OXAZINES
Authors: PEL'KIS N. P. , SLYUSARENKO E. I. , LEVCHENKO E. S.
Published: April 2016

Alkalische Cyclisierungen der Bromverbindungen (II) liefern die Titelverbindungen (III).
ChemInform Abstract: REACTIONS OF SILIRANES WITH ELEMENTAL SULFUR AND WITH TERT‐BUTYL MERCAPTAN. PREPARATION OF THE 2,3‐DITHIA‐1‐SILACYCLOPENTANE RING SYSTEM
Authors: SEYFERTH D. , DUNCAN D. P. , HAAS C. K.
Published: April 2016

Die gaschromatographische Auftrennung des Reaktionsgemisches aus der Umsetzung von (I) mit Schwefel (II) liefert die vier isomeren Produkte (III)‐(VI), die durch Schwefel‐Einschiebung und Umlagerung entstehen.
ChemInform Abstract: ORGANIC COMPOUNDS OF PHOSPHORUS. XII. AMMONIUM ACETATE/ACETIC ACID, A REAGENT T FOR THE DIRECT HETEROCYCLIZATION OF BIS‐ AND TRIS(1‐ALKYNYL)PHOSPHINE OXIDES
Authors: SKOLIMOWSKI J. , SIMALTY M.
Published: April 2016

Bis‐ (I) und Tris‐alkinyl‐phosphinoxide (III) cyclisieren beim Erhitzen mit Ammoniumacetat in Essigsäure zu 1,4‐Azaphosphorin‐Derivaten (II) bzw. (IV).
ChemInform Abstract: TRIENEIRON TRICARBONYL AND BISALLYLDIIRON HEXACARBONYL Π‐COMPLEXES FROM PHOTOLYSIS OF DIVINYLCYCLOPROPANES INDUCED BY IRON PENTACARBONYL
Authors: SAREL S. , LANGBEHEIM M. , RINGEL I.
Published: April 2016

Die Diene (I) reagieren mit Eisenpentacarbonyl bei Belichtung zu den isomeren Ketonen (III) u‐nd (IV) sowie den Komplexen (V)‐(VII).
ChemInform Abstract: RAPID AMIDE HYDROLYSIS MEDIATED BY COPPER AND ZINC
Authors: GROVES J. T. , DIAS R. M.
Published: April 2016

Untersuchungen zeigen, daß die Hydrolyse der Amid‐Bindung des in den 1:1‐Komplexen (IV) unter Deprotonierung koordinierten Liganden (III) wesentlich beschleunigt wird, liegt das Zentralmetallion senkrecht zu der Amid‐Ebene.
ChemInform Abstract: REACTION OF CIS‐ AND TRANS‐DIACIDODIAMMINEPLATINUM(II) WITH SULFUR‐CONTAINING DIPEPTIDES
Authors: MOGILEVKINA M. F. , RAR V. I. , NIKIFOROVA G. L. , CHEREMISINA I. M.
Published: April 2016

Durch Eindampfen wäßriger Lösungen der Pt(II)‐Komplexe (I) und (IV) nach Zusatz stöchiometrischer Mengen entsprechender Dipeptide werden in röntgenamorpher Form (II) und (V) isoliert (IR‐, UV‐Spektren).
ChemInform Abstract: USEFUL DETHIOACETALIZATION WITH SOFT ACID METAL SALTS: THALLIUM TRINITRATE AND MERCURIC PERCHLORATE
Authors: FUJITA E. , NAGAO Y. , KANEKO K.
Published: April 2016

Durch Tl(NO3)3 oder Hg(ClO4)2 werden aus Dithioacetalen, z.B. aus dem Steroiddithioacetal (I), die entsprechenden Carbonylverbindungen, z.B. (II), schonend und in hohen Ausbeuten regeneriert, auch in Anwesenheit von hydrolyseund oxidationsempfindlichen funktionellen Gruppen.
ChemInform Abstract: A CONVENIENT SYNTHESIS OF STEROIDAL NITROSOACETATES AND NITROACETATES
Authors: SHAFIULLAH D. , ALI H.
Published: April 2016

ö‐Oximinocholestane (I) reagieren mit Bleitetraacetat in Benzol/Essigsäure bei Raumtemperatur zu einem Gemisch aus 6ß‐Acetoxy‐öa‐rlitroso‐(II) und Sa‐Acetoxy‐öß‐nitrocholestanen (III).
ChemInform Abstract: FORMATION OF A THIO ANALOG OF NORACRONINE
Authors: DIMMOCK J. R. , REPTA A. J. , KAMINSKI J. J.
Published: April 2016

Bei der Umsetzung des krebshemmenden Alkaloids Acronin (I) mit P4S10 entsteht durch gleichzeitige Etherspaltung das Thionoracronin (II).
ChemInform Abstract: SYNTHESIS OF DAUNORUBICIN ANALOGS WITH NOVEL 9‐ACYL SUBSTITUENTS
Authors: SMITH T. H. , FUJIWARA A. N. , HENRY D. W.
Published: April 2016

Daunorubicin (Ia) liefert durch Alkylierung des entsprechenden Lithiumenolats das Propionylderivat (II), das in analoger Weise in das Keton (III) übergeführt wird.
ChemInform Abstract: Metallic Borides, La2Re3B7 and La3Re2B5, Featuring Extensive Boron—Boron Bonding.
Authors: Bugaris Daniel E. , Malliakas Christos D. , Chung Duck Young , Kanatzidis Mercouri G.
Published: April 2016

Single crystals of La2Re3B7 (I) and La3Re2B5 (II) are grown from mixtures containing the elements in the La:Re:B molar ratio of 1:3:5 covered by a La/Ni eutectic (compound (I)) or 1:2:1 with 1 equiv.
ChemInform Abstract: Luminescence Properties of Ca5Y3Na2(PO4)5 (SiO4)F2:Eu Phosphors.
Authors: Shi Yurong , Liu Bitao , Li Wan , Yang Xue , Ci Zhipeng , Li Chunyang , Wang Zhenling , Chen Fenghua
Published: April 2016

The phosphors Ca5Y3Na2(PO4)5 (SiO4)F2:xEu (0 ≤ x ≤ 0.1) are synthesized by solid state reaction of stoichiometric mixtures of CaCO3, Y2O3, Eu2O3, NaF, NH4H2PO4, and H2SiO3 (600 °C in air for 4 h, 1100 °C for 4 h in 95% N2/5% H2 atmosphere).
ChemInform Abstract: Studies on Crystallographic and Electrical Behavior of Neodymium Substituted Perovskite: La1‐xNdxMnO3.
Authors: Chourasia Rashmi , Shrivastava O. P. , Varma Vijay
Published: April 2016

La0.9Nd0.1MnO3 and La0.7Nd0.3MnO3 are prepared by firing stoichiometric amounts of La(NO3)3, Nd2O3, and MnCO3 (Pt crucible, 1.
ChemInform Abstract: Crystal Structure and Hydrogenation Properties of Pd5As.
Authors: Kohlmann H. , Vasseur M. , Sayede A. , Lefevre G. , Sander J. M. , Doyle S.
Published: April 2016

Single phase Pd5As is prepared by heating stoichiometric amounts of the elements (evacuated silica tubes, 973 K, 4 d).
ChemInform Abstract: Crystal and Magnetic Structures of the Oxide Sulfides CaCoSO and BaCoSO.
Authors: Salter Edward J. T. , Blandy Jack N. , Clarke Simon J.
Published: April 2016

CaCoSO (I) and BaCoSO (II) are prepared by solid state reaction of stoichiometric amounts of CaO (BaO), Co, and S (Al2O3 crucible in evacuated silica tubes, 25→900 °C resp.
ChemInform Abstract: The Ternary Ho—V—Ga System at 750 °C, and New Rare Earth Vanadium and Chromium Gallides.
Authors: Verbovytskyy Yuriy
Published: April 2016

A total of 46 binary and ternary phases within the title phase equilibrium are prepared by arc melting the elements followed by annealing (evacuated quartz tubes, 750 °C, 10 d).
ChemInform Abstract: Transition‐Metal‐Doped M‐Li8ZrO6 (M: Mn, Fe, Co, Ni, Cu, Ce) as High‐Specific‐Capacity Li‐Ion Battery Cathode Materials: Synthesis, Electrochemistry, and Quantum Mechanical Characterization.
Authors: Huang Shuping , Wilson Benjamin E. , Smyrl William H. , Truhlar Donald G. , Stein Andreas
Published: April 2016

Transition‐metal‐doped Li8ZrO6/C composites are prepared by heating mixtures of zirconyl nitrate, the dopant metal nitrate, and Super P carbon from room temperature to 400 °C followed by cooling back to room temperature.
ChemInform Abstract: Synthesis, Crystal Structure, and Optical Property of the Quaternary Chalcohalide Ba4Sb3S8Cl.
Authors: Zhao Hua‐Jun
Published: April 2016

The new title compound is prepared by solid state reaction of stoichiometric mixtures of BaCl2, Ba, Sb, and S (graphite crucible in evacuated silica tubes, 820 °C, 4 d; cooling to 320 °C at a rate of 5 °C/h).
ChemInform Abstract: LiNbO3‐Type Oxide (Tl1‐xScx)ScO3: High‐Pressure Synthesis, Crystal Structure, and Electronic Properties.
Authors: Belik Alexei A. , Yi Wei , Kumagai Yu , Katsuya Yoshio , Tanaka Masahiko , Oba Fumiyasu
Published: April 2016

Polycrystalline (Tl1‐xScx)ScO3 (x ≈0.26) is obtained by hot press sintering of stoichiometric amounts of Sc2O3 and Tl2O3 (Au or Pt capsules in belt‐type high‐pressure apparatus, 7.7 GPa, 1673 K, 1—2 h).
ChemInform Abstract: Synthesis, Structure, and Polymorphism of A3LnSi2O7 (A: Na, K; Ln: Sm, Ho, Yb).
Authors: Latshaw Allison M. , Yeon Jeongho , Smith Mark D. , zur Loye Hans‐Conrad
Published: April 2016

Crystals of K3SmSi2O7 (I) are grown from stoichiometric Sm2O3 and SiO2 in a KF flux (KF‐covered Ag crucible, 900 °C, 12 h).
ChemInform Abstract: Fast Synthesis of K0.5Na0.5NbO3 Powders at Low Temperatures by Microwave Hydrothermal Method.
Authors: Chen Liangping , Qiu Guibo , Peng Ben , Guo Min , Zhang Mei
Published: April 2016

Perfect cubic and well crystalline pure K0.5Na0.5NbO3 powders are prepared by microwave hydrothermal reaction of Nb2O5 in 6 M NaOH/KOH (1:5) solution (autoclave, 170 °C, 2 h).
ChemInform Abstract: Cesium Salts of Niobo‐Tungstate Isopolyanions with Intermediate Group V—Group VI Character.
Authors: Sures Dylan J. , Molina Pedro I. , Miro Pere , Zakharov Lev N. , Nyman May
Published: April 2016

Cs4Na2 [Nb4W2O19]·12H2O (I) and Cs3Na [Nb2W4O19]·10H2O (II) are prepared by acidification of an aq.
ChemInform Abstract: Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones.
Authors: Wakeham Russell J. , Morris James A. , Williams Jonathan M. J.
Published: April 2016

The application of cis‐1,4‐butenediol as a hydrogen source for the asymmetric transfer hydrogenation of ketones (I) and (III) is reported.
ChemInform Abstract: Entropy‐Driven 1,2‐Type Friedel—Crafts Reaction of Phenols with N‐tert‐Butoxycarbonyl Aldimines.
Authors: Kato Masaru , Hirao Shogo , Nakano Katsuhiro , Sato Makoto , Yamanaka Masahiro , Sohtome Yoshihiro , Nagasawa Kazuo
Published: April 2016

The 1,2‐type Friedel‐Crafts reaction of phenols with N‐Boc aromatic aldimines in the presence of a conformationally flexible chiral guanidine bisthiourea catalyst is studied.
ChemInform Abstract: Microwave‐Assisted Organocatalyzed Rearrangement of Propargyl Vinyl Ethers to Salicylaldehyde Derivatives: An Experimental and Theoretical Study.
Authors: Tejedor David , Cotos Leandro , Marquez‐Arce Daniel , Odriozola‐Gimeno Mikel , Torrent‐Sucarrat Miquel , Cossio Fernando P. , Garcia‐Tellado Fernando
Published: April 2016

According to a DFT study on a simplified model, the reaction proceeds via a domino process comprising a [3,3]‐propargyl Claisen rearrangement, a [1,3]—H shift, a [1,7]—H shift (enolization), a 6π electrocyclization, and an aromatization step.
ChemInform Abstract: Organocatalytic Radical Involved Oxidative Cross‐Coupling of N‐Hydroxyphthalimide with Benzylic and Allylic Hydrocarbons.
Authors: Dian Longyang , Wang Sisi , Zhang‐Negrerie Daisy , Du Yunfei
Published: April 2016

The cross‐coupling reaction between N‐hydroxyphthalimide and various benzylic and allylic hydrocarbons is realized through an organocatalytic radical‐mediated process involving C(sp3)—O bond formation using tert‐butyl hydroperoxide as an oxidant and tetra‐n‐butylammonium iodide as a catalyst, during which the phthalimide N‐oxyl radical and benzylic and allylic radicals are generated in situ and react selectively by a radical/radical cross‐coupling reaction.
ChemInform Abstract: Facile and Highly Diastereoselective Synthesis of syn‐ and cis‐1,2‐Diol Derivatives from Protected α‐Hydroxy Ketones.
Authors: Jahn Emanuela , Smrcek Jakub , Pohl Radek , Cisarova Ivana , Jones Peter G. , Jahn Ullrich
Published: April 2016

A new and diastereoselective method for the synthesis of 1,2‐diols from Tmp‐protected α‐hydroxyketones is developed.
ChemInform Abstract: Copper‐Catalyzed Vicinal Oxyazidation and Diazidation of Styrenes under Mild Conditions: Access to Alkyl Azides.
Authors: Lu Ming‐Zhu , Wang Cheng‐Qiang , Loh Teck‐Peng
Published: April 2016

A novel vicinal oxyazidation and diazidation of styrenes (I) using the stable azidoiodine reagent (II) as an azide source is described.
ChemInform Abstract: Palladium‐Catalyzed sp2 C—H Arylation of Azoarenes with Arylhydrazines.
Authors: Li Mingyang , Ye Yong
Published: April 2016

A Pd‐catalyzed oxidative ortho‐arylation of azoarenes (I) with arylhydrazines (II) is developed.
ChemInform Abstract: Dioxygen‐Mediated Decarbonylative C—H Alkylation of Heteroaromatic Bases with Aldehydes.
Authors: Paul Subhasis , Guin Joyram
Published: April 2016

The facile metal‐free and scalable protocol allows the direct alkylation of a wide range of heteroaromatic compounds with aliphatic aldehydes as alkyl radical precursors.
ChemInform Abstract: Stereocontrolled Synthesis of Vinyl Boronates and Vinyl Silanes via Atom‐Economical Ruthenium‐Catalyzed Alkene‐Alkyne Coupling.
Authors: Trost Barry M. , Koester Dennis C. , Herron Alastair N.
Published: April 2016

A highly chemo‐, regio‐, and stereoselective Ru‐catalyzed coupling of internal alkynes with allyl boronates is developed to give a diverse range of synthetically valuable vinyl boronates which can be used for further transformations.
ChemInform Abstract: Light‐Driven Carboxylation of o‐Alkylphenyl Ketones with CO2.
Authors: Masuda Yusuke , Ishida Naoki , Murakami Masahiro
Published: April 2016

The title reaction allows the convenient synthesis of arylacetic acids with ortho‐acylated aryl substituents.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Couplings of Vinylogous Enolates: Application to Statin Structures.
Authors: Makarov Ilya S. , Kuwahara Takashi , Jusseau Xavier , Ryu Ilhyong , Lindhardt Anders T. , Skrydstrup Troels
Published: April 2016

For the first time, Pd‐catalyzed carbonylative couplings of vinyl and aryl iodides with vinylogous enolates are reported.
ChemInform Abstract: Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α‐Hydroxy Ketones.
Authors: Dong Kaiwu , Sang Rui , Soule Jean‐Francois , Bruneau Christian , Franke Robert , Jackstell Ralf , Beller Matthias
Published: April 2016

Olefins are smoothly and with excellent regioselectivity converted into the corresponding α‐hydroxy ketones using a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of a N‐heterocyclic carbene.
ChemInform Abstract: Synthesis of Enamides by Ruthenium‐Catalyzed Reaction of Alkyl Azides with Acid Anhydrides in Ionic Liquid
Authors: Pak Han Kyu , Han Junghoon , Jeon Mina , Kim Yongjin , Kwon Yearang , Park Jin Yong , Rhee Young Ho , Park Jaiwook
Published: April 2016

50 examples
ChemInform Abstract: Amines vs. N‐Oxides as Organocatalysts for Acylation, Sulfonylation and Silylation of Alcohols: 1‐Methylimidazole N‐Oxide as an Efficient Catalyst for Silylation of Tertiary Alcohols.
Authors: Murray James I. , Spivey Alan C.
Published: April 2016

A comparison of the relative catalytic efficiencies of Lewis‐basic amines vs.
ChemInform Abstract: Integrated Process of Aerobic Oxidation—Olefination—Asymmetric C—C Bond Formation Catalyzed by Robust Heterogeneous Gold/Palladium and Chirally Modified Rhodium Nanoparticles.
Authors: Miyamura Hiroyuki , Suzuki Aya , Yasukawa Tomohiro , Kobayashi Shu
Published: April 2016

A tandem process of aerobic oxidation and Horner—Wadsworth—Emmons olefination is successfully catalyzed by gold/palladium bimetallic nanoparticles.
ChemInform Abstract: Copper‐Mediated Halotrifluoromethylation of Unactivated Alkenes.
Authors: An Won , Ha Neul , Lee Hyun Myung , Malpani Yashwardhan R. , Lee Duck‐Hyung , Jung Young‐Sik , Han Soo Bong
Published: April 2016

A copper‐mediated halotrifluoromethylation of unactivated alkenes using Umemoto′s reagent and a copper(I) halide is developed.
ChemInform Abstract: Synthesis of α‐Tertiary Amine Derivatives by Intermolecular Hydroamination of Unfunctionalized Alkenes with Sulfamates under Trifluoromethanesulfonic Acid Catalysis.
Authors: Fei Jun , Wang Zhen , Cai Zheren , Sun Hao , Cheng Xu
Published: April 2016

A trifluoromethanesulfonic acid‐catalyzed hydroamination of unfunctionalized alkenes leading to α‐tertiary amine derivatives at temperatures as low as room temperature is reported.
ChemInform Abstract: Dual Catalytic Decarboxylative Allylations of α‐Amino Acids and Their Divergent Mechanisms.
Authors: Lang Simon B. , O'Nele Kathryn M. , Douglas Justin T. , Tunge Jon A.
Published: April 2016

To circumvent traditional limitations in decarboxylative couplings, a dual palladium and photoredox catalytic process is developed.
ChemInform Abstract: A Triazole Organocatalyst with Spiropyrrolidine Framework and Its Application to the Catalytic Asymmetric Addition of Nitromethane to α,β‐Unsaturated Aldehydes.
Authors: Liu Wen‐Xing , Chen Si‐Kai , Tian Jin‐Miao , Tu Yong‐Qiang , Wang Shao‐Hua , Zhang Fu‐Min
Published: April 2016

A series of new water‐compatible spiropyrrolidine triazole catalysts is designed and synthesized.
ChemInform Abstract: Cyanoacetic Acid as a Masked Electrophile: Transition‐Metal‐Free Cyanomethylation of Amines and Carboxylic Acids.
Authors: Wang Hongxiang , Shao Ying , Zheng Hao , Wang Hanghang , Cheng Jiang , Wan Xiaobing
Published: April 2016

A novel cyanomethylation reaction of primary aromatic amines, secondary, and even tertiary amines as well as of carboxylic acids is described.
ChemInform Abstract: Iodine‐Mediated Copper‐Catalyzed Efficient α‐C(sp2)‐Thiomethylation of α‐Oxoketene Dithioacetals with Dimethyl Sulfoxide in One Pot.
Authors: Shukla Gaurav , Srivastava Abhijeet , Nagaraju Anugula , Raghuvanshi Keshav , Singh Maya Shankar
Published: April 2016

This operationally simple one‐pot protocol includes region‐defined consecutive iodination and sulfenylation of the challenging α‐C(sp2)—H bond of dithioacetals employing cheap and readily available reagents.
ChemInform Abstract: Nickel(0)/N‐Heterocyclic Carbene‐Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Two Enones and an Alkyne: Access to Cyclohexenes with Four Contiguous Stereogenic Centers.
Authors: Kumar Ravindra , Tokura Hiromu , Nishimura Akira , Mori Tadashi , Hoshimoto Yoichi , Ohashi Masato , Ogoshi Sensuke
Published: April 2016

A diastereoselective access to cyclohexenes bearing four contiguous stereogenic centers through enantioselective [2 + 2 + 2] cycloaddition of two enones and one alkyne is developed.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Tropone and Its Analogues via Oxidative Ring Expansion of Alkynyl Quinols.
Authors: Zhao Jidong , Liu Jun , Xie Xin , Li Shi , Liu Yuanhong
Published: April 2016

The new and convenient regioselective strategy allows access to seven and six‐membered ring systems including tropones, benzotropones, benzoxepines, phenanthrenes and quinolin‐2(1H)ones.
ChemInform Abstract: Highly Enantioselective Aza‐Michael Reaction Between Alkyl Amines and β‐Trifluoromethyl β‐Aryl Nitroolefins.
Authors: Wang Leming , Chen Jiean , Huang Yong
Published: April 2016

Chiral N‐heterocyclic carbenes are used as noncovalent organocatalysts for the highly selective aza‐Michael addition between primary alkyl amines and various nitroolefins affording chiral trifluoromethylated amines.
ChemInform Abstract: Catalytic Conjunctive Cross‐Coupling Enabled by Metal‐Induced Metallate Rearrangement.
Authors: Zhang Liang , Lovinger Gabriel J. , Edelstein Emma K. , Szymaniak Adam A. , Chierchia Matteo P. , Morken James P.
Published: April 2016

Vinyl boronic ester ate complexes, synthesized from organoboronates and organolithium reagents, are involved in palladium‐induced metallate rearrangements wherein an 1,2‐migration of an alkyl/aryl group from boron to the vinyl α‐carbon takes place simultaneously with a C—Pd σ‐bond formation.
ChemInform Abstract: Ring‐Opening of Pyridines with Acylacetylenes and Water: Straightforward Access to 5‐[(Z)‐Acylethenyl]amino‐2,4‐pentadienals.
Authors: Trofimov Boris A. , Andriyankova Ludmila V. , Belyaeva Kseniya V. , Nikitina Lina P. , Afonin Andrei V. , Mal'kina Anastasiya G.
Published: April 2016

A hitherto unknown family of Zincke aldehydes is obtained.
ChemInform Abstract: Iridium‐Catalyzed Enantioselective Allylic Substitution of Enol Silanes from Vinylogous Esters and Amides.
Authors: Chen Ming , Hartwig John F.
Published: April 2016

Enol silanes of vinylogous esters and amides react as nucleophiles with a wide range of allylic carbonates affording the allylated products with high enantioselectivities and excellent branched‐to‐linear ratios.
ChemInform Abstract: Design of Supported Organocatalysts from Carboxylic Acids for the Mannich‐Type Synthesis of β‐amino Carbonyl Compounds.
Authors: Sarma Parishmita , Saikia Susmita , Borah Ruli
Published: April 2016

β‐Amino carbonyl compounds (IV) are selectively synthesized via Mannich‐type reactions using silica‐supported trifluoroacetic acid as highly efficient reusable catalyst.
ChemInform Abstract: Iridium‐Catalyzed Direct ortho‐C—H Amidation of Benzoic Acids with Sulfonylazides
Authors: Wei Ming‐E , Wang Lian‐Hui , Li Yu‐Dong , Cui Xiu‐Ling
Published: April 2016

affording various anthranilic acid derivatives
ChemInform Abstract: A One‐Pot Amidation of Primary Nitroalkanes.
Authors: Schwieter Kenneth E. , Johnston Jeffrey N.
Published: April 2016

A facile protocol for the synthesis of amides from nitroalkanes through a tandem halogenation/umpolung amide synthesis is developed.
ChemInform Abstract: Nickel‐Catalyzed Arylation of Heteroaryl‐Containing Diarylmethanes: Exceptional Reactivity of the Ni(NIXANTPHOS)‐Based Catalyst.
Authors: Cao Xinyu , Sha Sheng‐Chun , Li Minyan , Kim Byeong‐Seon , Morgan Catherine , Huang Rudan , Yang Xiaodong , Walsh Patrick J.
Published: April 2016

In most cases, educts bearing one aryl and one pyridyl residue are used for the preparation of the desired triarylmethane products.
ChemInform Abstract: Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols.
Authors: Barbato Keith S. , Luan Yi , Ramella Daniele , Panek James S. , Schaus Scott E.
Published: April 2016

Conditions for the chemoselective formation of either chiral di‐ and triarylmethane products or chiral 2,4‐diaryl chromans are developed.
ChemInform Abstract: Asymmetric Synthesis of Spiroketals with Aminothiourea Catalysts.
Authors: Yoneda Naoki , Fukata Yukihiro , Asano Keisuke , Matsubara Seijiro
Published: April 2016

The intramolecular bis‐cyclization of α,β‐unsaturated carbonyl compounds (I) tethered with an hydroxy substituted alkylketone side chain is optimized in the presence of bifunctional thiourea catalyst to give spiroketals.
ChemInform Abstract: Synthesis of Difluoroalkyl‐γ‐butyrolactones from Iododifluoromethyl Ketones and 4‐Pentenoic Acids.
Authors: Wang Jie‐Xiong , Wu Jing‐Jing , Chen Heng , Zhang Shao‐Wu , Wu Fan‐Hong
Published: April 2016

The title lactones are efficiently obtained by radical addition reaction of aromatic iododifluoromethyl ketones with pentenoic acids involving a sequential radical difluoroalkylation and nucleophilic cyclization.
ChemInform Abstract: Catalyst‐Free Preparation of Heterocyclic Thienyl Sulfides
Authors: Barrett Kristen , McKee James , Zanger Murray
Published: April 2016

Title compounds [(III), (V), and (VII)] are easily synthesized under mild conditions using a neat and catalyst‐free procedure.
ChemInform Abstract: Pyridazine N‐Oxides as Precursors of Metallocarbenes: Rhodium‐Catalyzed Transannulation with Pyrroles.
Authors: Kanchupalli Vinaykumar , Joseph Desna , Katukojvala Sreenivas
Published: April 2016

The synthetic utility of the novel approach is demonstrated by the two‐step transformation of one product into the antiproliferative agent (VI).
ChemInform Abstract: A [4 + 1] Cyclative Capture Approach to 3H‐Indole‐N‐oxides at Room Temperature by Rhodium(III)‐Catalyzed C—H Activation.
Authors: Yang Yaxi , Wang Xuan , Li Yuanchao , Zhou Bing
Published: April 2016

Various indole‐N‐oxides are obtained by [4+1] C—H oxidative cyclization of nitrones with diazo compounds.
ChemInform Abstract: Asymmetric Broensted Acid Catalyzed Synthesis of Triarylmethanes—Construction of Communesin and Spiroindoline Scaffolds.
Authors: Liao Hsuan‐Hung , Chatupheeraphat Adisak , Hsiao Chien‐Chi , Atodiresei Iuliana , Rueping Magnus
Published: April 2016

The functionalization of indoles with alcohols (II) proceeds with high enantioselectivity to give triarylmethanes (III) and (VI).
ChemInform Abstract: Catalytic Enantioselective Arylative Dearomatization of 3‐Methyl‐2‐vinylindoles Enabled by Reactivity Switch.
Authors: Wang Yang , Sun Meng , Yin Lei , Shi Feng
Published: April 2016

The first catalytic asymmetric dearomatization of 3‐methyl‐2‐vinylindoles is established by using quinone monoimides as suitable electrophiles in the presence of a chiral phosphoric acid, which affords chiral indole derivatives bearing a quaternary stereogenic center in a chemospecific and highly enantioselective fashion.
ChemInform Abstract: Synthesis of (E)‐Oxindolylidene Acetate Using Tandem Palladium‐Catalyzed Heck and Alkoxycarbonylation Reactions.
Authors: Lin Wei‐Jen , Shia Kak‐Shan , Song Jen‐Shin , Wu Ming‐Hsien , Li Wen‐Tai
Published: April 2016

A tandem Pd‐catalyzed Heck and alkoxycarbonylation reaction for the stereoselective synthesis of (E)‐oxindolylidene acetates is presented.
ChemInform Abstract: A Highly Enantioselective Thiolation of Sulfonyl Indoles to Access 3‐sec‐Sulfur‐Substituted Indoles in Water.
Authors: Chen Ping , Lu Sheng‐mei , Guo Wengang , Liu Yan , Li Can
Published: April 2016

Vinylogous imine intermediates generated in situ from sulfonylindoles undergo asymmetric 1,4‐addition with trityl mercaptan (I) to form the title compounds with good to excellent enantioselectivities.
ChemInform Abstract: Synthesis of Isatins by the Palladium‐Catalyzed Intramolecular Acylation of Unactivated Aryl C(sp2)—H Bonds.
Authors: Li Jue , Zheng Yang , Yu Xinling , Lv Songyang , Wang Qiantao , Hai Li , Wu Yong
Published: April 2016

Using air as the oxidant, the PdCl2‐catalyzed intramolecular cyclization of N‐alkylglyoxalanilides gives the corresponding isatins in good to high yields.
ChemInform Abstract: Enantioselective Synthesis of Hemiaminals via Pd‐Catalyzed C—N Coupling with Chiral Bisphosphine Mono‐Oxides.
Authors: Li Hongming , Belyk Kevin M. , Yin Jingjun , Chen Qinghao , Hyde Alan , Ji Yining , Oliver Steven , Tudge Matthew T. , Campeau Louis‐Charles , Campos Kevin R.
Published: April 2016

A novel approach to the enantioselective synthesis of hemiaminals via Pd‐catalyzed C—N coupling using commercially available chiral bisphosphine ligands is developed.
ChemInform Abstract: Gold(I)‐Catalyzed Dearomative [2 + 2]‐Cycloaddition of Indoles with Activated Allenes: A Combined Experimental—Computational Study.
Authors: Ocello Riccardo , De Nisi Assunta , Jia Minqiang , Yang Qing‐Qing , Monari Magda , Giacinto Pietro , Bottoni Andrea , Miscione Gian Pietro , Bandini Marco
Published: April 2016

The scope of the reaction encompasses both allenamides and aryloxyallenes as electrophilic partners.
ChemInform Abstract: Diversification of Edaravone via Palladium‐Catalyzed Hydrazine Cross‐Coupling: Applications Against Protein Misfolding and Oligomerization of Beta‐Amyloid.
Authors: MacLean Mark A. , Diez‐Cecilia Elena , Lavery Christopher B. , Reed Mark A. , Wang Yanfei , Weaver Donald F. , Stradiotto Mark
Published: April 2016

A library of 21 N‐aryl derivatives of edaravone is obtained by palladium‐catalyzed hydrazine monoarylation.
ChemInform Abstract: The First Example of an Unusual Rearrangement in the van Leusen Imidazole Synthesis.
Authors: Fodili Mokhtar , Nedjar‐Kolli Bellara , Vedrenne Marc , Saffon‐Merceron Nathalie , Lherbet Christian , Hoffmann Pascal
Published: April 2016

The imidazole ring system (V) can be prepared by reaction of TosMIC (IV) with a tautomeric enamine form (III) of a secondary ketimine.
ChemInform Abstract: A Facile Synthesis of 2,5‐Disubstituted Oxazoles via a Copper‐Catalyzed Cascade Reaction of Alkenes with Azides.
Authors: Li Jiu‐ling , Wang Ying‐chun , Li Wei‐ze , Wang Heng‐shan , Mo Dong‐liang , Pan Ying‐ming
Published: April 2016

Disubstituted oxazoles are synthesized via a novel and efficient method including 1,3‐dipolar cycloaddition/ring cleavage/1,2‐H migration/denitrogenation/copper‐catalyzed aerobic oxidative dehydrogenative cyclization cascade.
ChemInform Abstract: Silver‐Catalyzed Cyclization of Propargylic Amides to Oxazolines.
Authors: Wong Valerie H. L. , White Andrew J. P. , Hor T. S. Andy , Hii King Kuok Mimi
Published: April 2016

A ligand‐accelerated effect is observed in the cyclization of propargylic amides catalyzed by bis(pyridyl)silver(I) complexes, with an unexpected reversal of electronic demand to the analogous N—H addition reaction.
ChemInform Abstract: Metal‐Free Intermolecular Azide‐Alkyne Cycloaddition Promoted by Glycerol.
Authors: Rodriguez‐Rodriguez Marta , Gras Emmanuel , Pericas Miquel A. , Gomez Montserrat
Published: April 2016

The effect of glycerol in these metal‐free intermolecular Huisgen cycloadditions is rationalized with the help of DFT calculations.
ChemInform Abstract: Aldol Additions of Titanium and Boron Enolates of Achiral and Chiral δ‐Lactones to Achiral Model Aldehydes: Simple and Induced Diastereoselectivities.
Authors: Weber Fabian , Becker Fabian , Keller Manfred , Hillebrecht Harald , Brueckner Reinhard
Published: April 2016

It is found that titanium enolates in most cases syn‐selectively react with achiral aldehydes, whereas boron enolates react anti‐selectively in all cases.
ChemInform Abstract: Asymmetric Synthesis of 3,4‐Dihydrocoumarins Bearing an α,α‐Disubstituted Amino Acid Moiety.
Authors: Hejmanowska Joanna , Albrecht Anna , Pieta Jakub , Albrecht Lukasz
Published: April 2016

An organocatalytic approach for the stereoselective synthesis of 3,4‐dihydrocoumarins with an α,α‐disubstituted amino acid moiety incorporated is presented.
ChemInform Abstract: The Regioselective Iodination of Quinolines, Quinolones, Pyridones, Pyridines and Uracil.
Authors: Dutta Uttam , Deb Arghya , Lupton David W. , Maiti Debabrata
Published: April 2016

The title iodination is a radical based direct C—H iodination, which occurs at C3 or/and C5 position depending on the substrates.
ChemInform Abstract: Regioselective Synthesis of 1,2‐ and 1,4‐Dihydroquinolines by Palladium‐Catalyzed Intramolecular N‐Arylation.
Authors: Park Kyeong‐Yong , Lee Jinyong , Park Seong Jun , Heo Jung‐Nyoung , Lim Hwan Jung
Published: April 2016

A series of 1,2‐ and 1,4‐dihydroquinolines is prepared by Pd‐catalyzed intramolecular N‐arylation of Z‐enamines, formally prepared by the Horner—Wadsworth—Emmons olefination.
ChemInform Abstract: One‐Pot Dichotomous Construction of Inside‐Azayohimban and Pro‐Azayohimban Systems via an Enantioselective Organocatalytic Cascade; Their Use as a Model to Probe the (Aza‐)Indole Local Solvent Environment.
Authors: Yang Van‐Wei , Hong Bor‐Cherng , Kao Hsin‐Kai , Tu Ting‐Hsun , Shen Jiun‐Yi , Chen Chi‐Lin , Lee Gene‐Hsiang , Chou Pi‐Tai
Published: April 2016

Five contiguous stereocenters containing inside‐azayohimban (X) and pro‐azayohimban (IVa) as well as derivatives thereof are prepared and their photochemical properties are examined.
ChemInform Abstract: Tetraalkylammonium Salts as Hydrogen‐Bonding Catalysts.
Authors: Shirakawa Seiji , Liu Shiyao , Kaneko Shiho , Kumatabara Yusuke , Fukuda Airi , Omagari Yumi , Maruoka Keiji
Published: April 2016

Newly designed tetraalkylammonium salts (TAS) are investigated as hydrogen‐bonding catalysts for coupling reactions of chlorodihydroisoquinolines (I) with ketene acetals (II) or silyl enol ethers (IV).
ChemInform Abstract: One‐Pot, Facile, Highly Efficient, and Green Synthesis of Acridinedione Derivatives Using Vitamin B1.
Authors: Isik Ahmet , Aday Burak , Ulus Ramazan , Kaya Muharrem
Published: April 2016

Title compounds (IV) are efficiently synthesized through a one‐pot multicomponent condensation in the presence of the easily available, inexpensive, and nontoxic catalyst vitamin B1.
ChemInform Abstract: Core‐Scaffold‐Inspired Asymmetric Synthesis of Polysubstituted Chiral Hexahydropyridazines that Potently Inhibit Breast Cancer Cell Proliferation by Inducing Apoptosis.
Authors: Leng Hai‐Jun , Peng Fu , Zingales Sarah , Huang Wei , Wang Biao , Zhao Qian , Zhou Rui , He Gu , Peng Cheng , Han Bo
Published: April 2016

This asymmetric cascade approach utilizes an organocatalytic Michael reaction followed by intermolecular α‐amination and intramolecular hemiaminalization to yield chiral pyridazines with four or five contiguous stereogenic centers.
ChemInform Abstract: Green and Catalyst‐Free One‐Pot Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones in Water.
Authors: Olyaei Abolfazl , Rahbarian Fatemeh , Sadeghpour Mahdieh
Published: April 2016

A simple, highly efficient and straightforward method for the formation of the title compounds via three‐component coupling reactions of isatoic anhydride with aromatic aldehydes and aniline or NH4OAc is developed.
ChemInform Abstract: Metal‐Free [4 + 2] Annulation of Arylalkynes with tert‐Butyl Nitrite Through C(sp2)—H Oxidation to Assemble Benzo[e][1,2]oxazin‐4‐ones.
Authors: Yang Xu‐Heng , Song Ren‐Jie , Li Jin‐Heng
Published: April 2016

A metal‐free radical‐mediated [4+2] annulation of internal arylalkynes with tert‐butyl nitrite is presented for the synthesis of benzoxazinones through the addition of t‐BuONO across the CC triple bond, hydration, isomerization, and aromatic C(sp2)—H oxidation cascades.
ChemInform Abstract: Calcium‐Catalyzed Synthesis of 1,2‐Disubstituted 3‐Benzazepines.
Authors: Damsen Helena , Niggemann Meike
Published: April 2016

The title benzazepines are highly stereoselectively synthesized using simple enantiopure amino acids as chiral building blocks.
ChemInform Abstract: Modular Access to the Stereoisomers of Fused Bicyclic Azepines: Rhodium‐Catalyzed Intramolecular Stereospecific Hetero‐[5 + 2] Cycloaddition of Vinyl Aziridines and Alkenes.
Authors: Feng Jian‐Jun , Lin Tao‐Yan , Wu Hai‐Hong , Zhang Junliang
Published: April 2016

The title method provides fused azepine derivatives having multiple contiguous stereogenic centers.
ChemInform Abstract: Enantioselective Construction of the Biologically Important Cyclopenta[1,4]diazepine Framework Enabled by Asymmetric Catalysis by Chiral Spiro‐Phosphoric Acid.
Authors: Sun Meng , Wang Yang , Yin Lei , Cao Yang‐Yan , Shi Feng
Published: April 2016

The first catalytic asymmetric construction of the chiral title diazepines by three‐component tandem reactions of cyclopentanedione, phenylenediamine, and various isatins under mild reaction conditions using a chiral spiro‐phosphoric acid catalyst is presented.
ChemInform Abstract: The Synthesis of Structurally Diverse Macrocycles by Successive Ring Expansion.
Authors: Kitsiou Christiana , Hindes Jordan J. , I'Anson Phillip , Jackson Paula , Wilson Thomas C. , Daly Eleanor K. , Felstead Hannah R. , Hearnshaw Peter , Unsworth William P.
Published: April 2016

MgCl2‐ and pyridine‐promoted α‐acylation of cyclic β‐ketoesters [cf.
ChemInform Abstract: Palladium‐Catalyzed Regio‐ and Chemoselective Reactions of 2‐Bromobenzyl Bromides: Expanding the Scope for the Synthesis of Biaryls Fused to a Seven‐Membered Sultam.
Authors: Laha Joydev K. , Sharma Shubhra , Dayal Neetu
Published: April 2016

The title sultams are rapidly and easily obtained starting from readily accessible N‐alkyl‐benzenesulfonamides and bromobenzylbromides by domino reaction involving an N‐benzylation followed by an intramolecular direct C—H arylation ortho to the sulfonamide group.
ChemInform Abstract: Acylsilanes in Iridium‐Catalyzed Directed Amidation Reactions and Formation of Heterocycles via Siloxycarbenes.
Authors: Becker Peter , Pirwerdjan Ramona , Bolm Carsten
Published: April 2016

A highly efficient ortho‐amidation of aroylsilanes with sulfonyl azides is developed.
ChemInform Abstract: Triflimide‐Catalyzed Rearrangement of N‐(1‐Trimethylsilyl)allylhydrazones Results in the Formation of Vinylsilanes and Cyclopropanes.
Authors: Dittrich Sebastian , Bracher Franz
Published: April 2016

Terminal vinylsilanes are obtained by triflimide‐catalyzed rearrangement of the title hydrazones.
ChemInform Abstract: Facile Alder‐Ene Reactions of Silylallenes Involving an Allenic C(sp2)—H Bond.
Authors: Sabbasani Venkata R. , Huang Genping , Xia Yuanzhi , Lee Daesung
Published: April 2016

A silyl substituent is critical for the observed reactivity and selectivity in the Alder‐ene reactions of silylallenes with azodicarboxylate, ethyl glyoxylate, or benzyne.
ChemInform Abstract: Selective Alkenylation and Hydroalkenylation of Enol Phosphates Through Direct C—H Functionalization.
Authors: Hu Xu‐Hong , Yang Xiao‐Fei , Loh Teck‐Peng
Published: April 2016

The first Rh‐catalyzed cross‐coupling reactions of enol phosphates with a variety of activated alkenes and propyne derivatives (XIV) are described.
ChemInform Abstract: ent‐Abietane‐Type Diterpenoids from the Roots of Euphorbia ebracteolata with Their Inhibitory Activities on LPS‐Induced NO Production in RAW 264.7 Macrophages.
Authors: Liu Zhi‐guo , Li Zhan‐lin , Li Da‐hong , Li Ning , Bai Jiao , Zhao Feng , Meng Da‐li , Hua Hui‐ming
Published: April 2016

Four new ent‐abietane diterpenoids, ebractenoids K—N, are isolated along with six known ones from the roots of Euphorbia ebracteolata.
ChemInform Abstract: Sesquiterpenes and Prenylated C6—C3 Compounds from the Stems of Illicium henryi.
Authors: Zhuang Peng‐Yu , Zhang Gui‐Jie , Wang Xiao‐Jing , Zhang Yan , Yu Shi‐Shan
Published: April 2016

One new sesquiterpene, illihenlactone A (I), and a new prenylated sesquiterpene, illihenryione H (II), are isolated along with three known sesquiterpenes.
ChemInform Abstract: A Novel Selectfluor‐Mediated Regioselective O‐Benzyl Ether Acetolysis of Perbenzylated Monosaccharides.
Authors: Tambie Marlon S. , Jalsa Nigel Kevin
Published: April 2016

Selectfluor‐mediated benzyl group acetolysis is proved to be a mild and easy method to obtain partially benzylated and partially acetylated carbohydrates.
ChemInform Abstract: The Structure of Tagetitoxin.
Authors: Aliev Abil E. , Karu Kersti , Mitchell Robin E. , Porter Michael J.
Published: April 2016

Previously published structures of the potent title toxin are falsified.
ChemInform Abstract: Diffusion‐Assisted Synthesis of Co2FeSn Heusler Nanoparticles and Their Magnetic Properties.
Authors: Li Pengpeng , Kou Xinli
Published: April 2016

Co2FeSn Heusler nanoparticles (5—12 nm particle size) are prepared by boiling Co2Fe and Sn nanoparticles in tetraethylene glycol (stirring, 230 °C, 24 h) which results in diffusion of molten Sn into Co2Fe nanoparticles.
ChemInform Abstract: Electrically Conductive Porous Metal‐Organic Frameworks
Authors: Sun Lei , Campbell Michael G. , Dinca Mircea
Published: April 2016

Review: synthetic and electronic design strategies as well as selected applications of the title MOFs; 101 refs.
ChemInform Abstract: Schiff Base‐Derived Homogeneous and Heterogeneous Palladium Catalysts for the Suzuki—Miyaura Reaction
Authors: Das Pankaj , Linert Wolfgang
Published: April 2016

Review: 169 refs.
ChemInform Abstract: Catalytic Organic Transformations Mediated by Actinide Complexes
Authors: Karmel Isabell S. R. , Batrice Rami J. , Eisen Moris S.
Published: April 2016

Review: 107 refs.
ChemInform Abstract: Thioesters Synthesis: Recent Adventures in the Esterification of Thiols
Authors: Kazemi Mosstafa , Shiri Lotfi
Published: April 2016

Review: 67 refs.
ChemInform Abstract: The Concept of Multicatalysis in Aerobic Oxidation of Alcohols
Authors: Davi Michael , Lebel Helene
Published: April 2016

Review: 82 refs.
ChemInform Abstract: Advances in the Synthesis and Application of Isoindigo Derivatives
Authors: Bogdanov Andrei V. , Musin Lenar I. , Mironov Vladimir F.
Published: April 2016

Review: 132 refs.
ChemInform Abstract: Ester Coupling Reactions — An Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products
Authors: Tsakos Michail , Schaffert Eva S. , Clement Lise L. , Villadsen Nikolaj L. , Poulsen Thomas B.
Published: April 2016

Review: 285 refs.
ChemInform Abstract: Diverse Natural Products from Dichlorocyclobutanones: An Evolutionary Tale
Authors: Depres Jean‐Pierre , Delair Philippe , Poisson Jean‐Francois , Kanazawa Alice , Greene Andrew E.
Published: April 2016

Review: 73 refs.
ChemInform Abstract: Catalysts Containing the Adamantane Scaffold
Authors: Agnew‐Francis Kylie A. , Williams Craig M.
Published: April 2016

Review: [143 refs.
ChemInform Abstract: Synthesis of Spirocyclic Indolenines
Authors: James Michael J. , O'Brien Peter , Taylor Richard J. K. , Unsworth William P.
Published: April 2016

Review: 191 refs.
ChemInform Abstract: Enantioselective Syntheses of Indanes: From Organocatalysis to C—H Functionalization
Authors: Borie Cyril , Ackermann Lutz , Nechab Malek
Published: April 2016

Review: [144 refs.
ChemInform Abstract: Precipitation Polymerization: A Versatile Tool for Preparing Molecularly Imprinted Polymer Beads for Chromatography Applications
Authors: Pardeshi Sushma , Singh Sunit Kumar
Published: April 2016

Review: 116 refs.
ChemInform Abstract: Mild Radical Oxidative sp3‐Carbon—Hydrogen Functionalization: Innovative Construction of Isoxazoline and Dibenz[b,f]oxepine/azepine Derivatives
Authors: Gini Andrea , Garcia Mancheno Olga
Published: April 2016

Review: [46 refs.
ChemInform Abstract: Catalytic α‐Alkylation/Reduction of Ketones with Primary Alcohols to Furnish Secondary Alcohols
Authors: Lundberg Helena , Adolfsson Hans
Published: April 2016

Review: [38 refs.
ChemInform Abstract: Exploring the Aldol Reaction in the Synthesis of Bioactive Compounds
Authors: Ferreira Marco A. B. , Dias Luiz C. , Leonarczyk Ives A. , Polo Ellen C. , de Lucca Emilio C.
Published: April 2016

Review: 143 refs.
ChemInform Abstract: Palladium‐Catalyzed Oxyarylation, Azaarylation and α‐Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues
Authors: Buarque Camilla D. , Domingos Jorge L. O. , Netto Chaquip D. , Costa Paulo R. R.
Published: April 2016

Review: 132 refs.
ChemInform Abstract: Synthesis of Diastereomers of Alliin, Selenoalliin, and Isoalliin
Authors: Jayathilaka Lasanthi , Gupta Shalini , Huang Jin‐Sheng , Lee Jenny , Lee Bao‐Shiang
Published: April 2016

Review: 48 refs.
ChemInform Abstract: Synthetic Transformations of Ent‐kaurenoic Acid
Authors: Morarescu Olga
Published: April 2016

Review: 53 refs.
ChemInform Abstract: Recent Advances in 1,10‐Phenanthroline Ligands for Chemosensing of Cations and Anions
Authors: Alreja Priya , Kaur Navneet
Published: April 2016

Review: 242 refs.
Optimization of Polyhydroxybutyrate Production by Bacillus safensis EBT1
Authors: Madhumathi Ramasamy , Muthukumar Karuppan , Velan Manickam
Published: April 2016

The present study deals with the enhanced production of polyhydroxybutyrate (PHB) using a novel potent strain. On the basis of morphological, biochemical, and 16S rRNA analysis, the strain was identified as Bacillus safensis EBT1. The presence of PHB in the cells was identified and affirmed using fluorescent microscopy and Fourier transform infrared spectroscopy. The molecular weight of PHB was ascertained by gel permeation chromatography. Under optimized conditions, B. safensis EBT1 showed maximum PHB production and growth with glucose as the carbon source, yeast extract as the nitrogen source, and sugarcane bagasse as the substrate. The process parameters were optimized using central composite design: pH 7, 45 °C and 48 h incubation time. At these conditions, highest biomass concentration of 7.54 g/L and PHB production of 6.41 g/L were observed.
Neighbor palatability generates associational effects by altering herbivore foraging behavior
Authors: Hahn Philip G. , Orrock John L.
Published: April 2016

Despite increasing evidence that herbivory on a focal plant may hinge upon the identity of its neighbors, it is not clear whether predictable mechanisms govern the nature and magnitude of such associational effects. Using a factorial field experiment replicated at 14 sites across 80,000 hectares, we evaluated the mechanisms driving associational effects between two plant species mediated by grasshopper herbivores. Our experiment manipulated local neighborhood plant density (two levels) and frequency (three levels), nested within two larger‐scale habitat contexts (habitats that did or did not have past agricultural land use). We found that the more palatable plant species, Solidago nemoralis, experienced reduced herbivory (associational resistance) when rare due mainly to reduced grasshopper foraging activity. Damage to the less palatable plant species, S. odora, was affected by the interaction between plant frequency and the land‐use history of the site: it experienced increased damage (associational susceptibility) in even‐frequency neighborhoods, but only in sites with a history of agricultural use. Behavioral assays generally corroborated the results from the field, further supporting the importance of foraging behavior in generating associational effects. In finding that associational effects are contingent upon relative palatability among plants and events in the distant past that modify contemporary habitat structure (i.e., past agricultural land use), our work suggests that foraging decisions made at the neighborhood level are important for generating associational effects and that in some cases these neighborhood interactions also depend on the larger‐scale environmental context resulting from legacies of past land‐use events.
Interactive effects of shelter and conspecific density shape mortality, growth, and condition in juvenile reef fish
Authors: Ford John R. , Shima Jeffrey S. , Swearer Stephen E.
Published: April 2016

How landscape context influences density‐dependent processes is important, as environmental heterogeneity can confound estimates of density dependence in demographic parameters. Here we evaluate 19 populations in a shoaling temperate reef fish (Trachinops caudimaculatus) metapopulation within a heterogeneous seascape (Port Phillip Bay, Australia) to show empirically that shelter availability and population density interact to influence juvenile mortality, growth and condition. Although heterogeneity in shelter availability obscured the underlying patterns of density dependence in different ways, the combination of habitat and its interaction with density were two to six times more important than density alone in explaining variation in demographic parameters for juveniles. These findings contradict many small‐scale studies and highlight the need for landscape‐scale observations of how density dependence interacts with resource availability and competition to better understand how demographic parameters influence the dynamics of metapopulations in heterogeneous environments.
Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed‐type hypersensitivity
Authors: Sido Jessica M. , Nagarkatti Prakash S. , Nagarkatti Mitzi
Published: April 2016

Endocannabinoids are endogenous ligands for the cannabinoid (CB) receptors which include anandamide (AEA) and 2‐arachidonyl glycerol (2‐AG). 2‐AG has been linked to inflammation due to its elevated expression in animal models of autoimmunity and hypersensitivity. However, administration of exogenous 2‐AG has been shown to suppress inflammation making its precise role unclear. In the current study, we investigated the role of 2‐AG following immunization of C57BL/6 (BL6) mice with methylated BSA (mBSA) antigen, which triggers both delayed‐type hypersensitivity (DTH) and antibody response. We found that while naïve T cells and B cells expressed low levels of 2‐AG, expression significantly increased upon activation. Furthermore, mBSA‐immunized mice exhibited higher 2‐AG concentration than naïve mice. Exogenous 2‐AG treatment (40 mg/kg) in mBSA‐immunized mice led to reduced DTH response, and decreased Th1 and Th17‐associated cytokines including IL‐6, IL‐2, TNF‐α, and the IgG response. Addition of 2‐AG to activated popliteal lymph node (PopLN) cell cultures also inhibited lymphocyte proliferation. Together, these data show for the first time that activated T and B cells produce 2‐AG, which plays a negative regulatory role to decrease DTH via inhibition of T‐cell activation and proliferation. Moreover, these findings suggest that exogenous 2‐AG treatment can be used therapeutically in Th1‐ or Th17‐driven disease.