bluuebunny/crossref_metadata_2025 huggingface dataset:
Slower, shorter, sadder: A qualitative study exploring how dog walks change when the canine participant develops osteoarthritis
Authors: Belshaw Zoe , Asher Lucy , Dean Rachel S
Published: August 2019

Background: Dog walking may have multiple physical and mental health advantages, but not all dog owners appear to benefit. Dog health is a described barrier to dog walking activity, but specific causes and impacts of reduced exercise in owners of dogs with health problems have not previously been reported. The current study used a qualitative methodology to explore the impact of canine osteoarthritis on dog walking activity.
Methods: Owners of dogs with osteoarthritis living in the United Kingdom (UK) were recruited through veterinary practices for semi-structured interview about life with an osteoarthritic dog. Participants were asked to reflect on walks that they had taken with their dog before he/she developed osteoarthritis, and to describe how those walks had changed. Interviews were transcribed verbatim and thematic analysis was used to construct key themes.
Results: Forty owners of 35 osteoarthritic dogs were interviewed. Prior to their dog’s development of osteoarthritis, dog walking distance, speed and location were usually decided by the owner to satisfy the needs and enjoyment of dog and walker. A diagnosis of canine osteoarthritis led to both dogs and their owners altering the walks undertaken. Walks were typically slower, shorter and limited to locations where physical infrastructure, underfoot surface and gradients were perceived by the owner to be navigable by their dog. Most owners did not go on additional walks without their dog due to feelings of guilt and because walking without a dog was less enjoyable. Many owners described negative effects on their own physical health and diminished enjoyment of walking as a result of their dog’s condition.
Conclusion: Our research suggests that osteoarthritic dogs may reduce the walking exercise their owners are able or willing to undertake. Since osteoarthritis is a common condition in older dogs, this is an important finding for those advocating dog ownership as a positive public health intervention. Strategies may be needed to ensure that owners of dogs that develop physical incapacities can continue to enjoy the health benefits they previously associated with dog walking. Future studies investigating dog walking activity should ensure that the health status of the dog has been considered.
Comparative metabolome analysis of serum changes in sheep under overgrazing or light grazing conditions
Authors: Zhang Jize , Gao Yang , Guo Huiqin , Ding Yong , Ren Weibo
Published: August 2019

Background Overgrazing is a primary contributor to severe reduction in forage quality and production in Inner Mongolia, leading to extensive ecosystem degradation, sheep health impairment and growth performance reduction. However, no clear information about the effect of overgrazing on sheep health and nutritional metabolism is available because no objective biomarkers are currently evident. We hereby hypothesize that reduced sheep growth performance under overgrazing conditions would be associated with metabolic and immune alterations. This study used an untargeted metabolomics analysis by conducting ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) of sheep serum under overgrazing and light grazing conditions to identify metabolic disruptions in response to overgrazing.Results The sheep daily body weight gain as well as serum biochemical parameters associated with immune responses, protein synthesis and energy production (immunoglobulin G, albumin, glucose, and nonesterified fatty acids) were significantly decreased with overgrazing than under the light grazing condition. In contrast, other serum parameters such as alanine and aspartate aminotransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, and interleukin-8 were markedly higher in the overgrazing group. Principal component analysis discriminated the metabolomes of the light grazing from the overgrazing group. Multivariate and univariate analyses revealed alternations in the serum concentrations of 15 metabolites (9 metabolites exhibited a marked increase, whereas 6 metabolites showed a significant decrease) in the overgrazing group. Major alterations of fatty acid oxidation, bile acid biosynthesis, and purine and protein metabolism were observed.Conclusions These findings offer metabolic evidence for putative biomarkers for overgrazing-induced changes in serum metabolism. Target-identification of these particular metabolites may potentially increase our knowledge of the molecular mechanisms of impaired sheep health and reduced sheep growth performance under overgrazing conditions.
Knowledge On Neonatal Danger Signs And Associated Factors Among Mothers Who Gave Birth In The Last One Year Prior To This Study In Debre Markos Town, East Gojjam, Northwest Ethiopia 2017: A Community Based Cross Sectional Study.
Authors: Yirdaw Birhanu Wubale , Badi Marta Berta , Gudayu Temesgen Worku , Tamiru Animut Tagele , Ayinalem Getie Lake , Bante Simachew Animen , Dessalegni Samuel Abebe
Published: August 2019

Abstract
Background: Neonatal mortality is a concern for global population especially in developing countries. The majority of neonatal mortality occurs at home where only few families recognize key danger signs of neonatal illness. Thus, we assessed the knowledge on neonatal danger signs of illness and associated factors among mothers who gave birth in the last one year prior to this study in Debre Markos town, East Gojjam, northwest Ethiopia.
Methods: A community-based, cross-sectional study was conducted among 521 mothers. Cluster sampling technique was used to select the study participants and interviewed using structured and pre-tested questionnaire. Data were entered to Epi Info and exported to SPSS for analysis. Variables in binary logistic regression with a P value <0.2 were fitted to multivariable logistic regression. Significant variables were declared at 95% CI and a P value <0.05.
Results: A total 473 participants were interviewed by making a response of 91.0%. The proportion of knowledgeable mothers was found to be 26.2% (95% CI 22.2, 30.4). Mother’s secondary and tertiary education(AOR=3.64, 95% CI 1.14, 11.61 and AOR=3.80, 95% CI 1.25, 11.56), husband’s secondary and tertiary education(AOR=4.22, 95% CI 1.53, 11.60 and AOR=4.34, 95% CI 1.52, 12.37) respectively, antenatal care attendance(AOR = 3.54, 95% CI 1.62, 7.75), postnatal care attendance(AOR = 2.41, 95% CI 1.13, 5.14), getting prepared for birth(AOR =2.43, 95% CI 1.20, 4.89) and access for television(AOR = 2.06, 95% CI 1.01, 4.21) were found to be positively associated with being knowledgeable on neonatal danger signs.
Conclusion: Mothers’ knowledge on neonatal danger signs was low. The finding showed that, intervention modalities to increase parental education, both antenatal and postnatal care attendance, mothers’ preparedness for birth and advocating the use of television might be helpful to improve mothers’ knowledge on neonatal danger signs.
Key words: Neonatal Danger Signs, Mothers’ Knowledge, East Gojjam, Ethiopia
Recursos de la web 2.0 aplicados en el aula invertida en apoyo del proceso de formación profesional del psicólogo
Authors: Fernández Sánchez Néstor , Quispe Palpa Paola Alexandra
Published: August 2019

El objetivo de este estudio fue favorecer el aprendizaje de los conceptos relacionados con los primeros días de la vida, desde la perspectiva de la Psicología, en un grupo de 114 estudiantes de la carrera de psicología,aprovechando principios metodológicos del aula invertida, bajo la hipótesis de que el aprendizaje relacionado con los primeros días de la vida, desde la perspectiva de la psicología se verá favorecido al aplicar estrategias de enseñanza derivadas de la propuesta Aula invertida. El estudio se desarrolló bajo el método cuasiexperimental pretest-postest, con una muestra asignada por conveniencia, en el que se aplicó un cuestionario elaborado ad hoc para explorar los conocimientos previos y posteriores a un curso. La diferencia de 53.76 (p< 0.001, con T-Student) entre las calificaciones iniciales y finales generales, así como en cada tema específico permiten confirmar que la forma de trabajo realizada bajo los principios de Aula invertida benefició el aprendizaje de los conceptos deseados.
Innovative controlling and audit – opportunities for SMEs
Authors: Písař Přemysl , Kupec Václav
Published: August 2019

This research is oriented to SME’s innovation activities, its management system and competitiveness based on innovations. Research is focused on causalities between innovative controlling, audit, enterprise innovation activities and the results put in context with ROA, ROE, turnover. Data for this research were collected in 317 European SMEs by researches by using questionnaire and analyzed by advanced statistical methods. The aim of this research is to identify key factors for successful innovation enterprise activities, to define weaknesses and common mistakes. Secondary aim is to design controlling process for SME’s innovation activities. The findings of this research are opening up topics for further research.
DEFINING “FINANCIAL STABILITY”
Authors: Stefaniak Stanisław
Published: August 2019

After the Global Financial Crisis (GFC) of 2008 the term “financial stability” rose to prominence in financial regulatory circles. The paper employs methodological tools from political economy, discourse analysis and comparative legal analysis to track the trajectory of this rise in the narratives of scholarship on financial law, policy documents and relevant European legislation and finds that the meaning of the term is subject to change and malleable. It is argued that the substance of financial stability can only be deciphered once the broader ideas about the functioning of financial markets and roles of central banks are taken into context. It is then established that these ideas were redefined in the aftermath of the GFC in line with the new macroprudential paradigm, and how they came to inform subsequent policies and legislation in the European Union.
Efeito de uma intervenção nutricional no conhecimento sobrenutrição entre alunos do ensino fundamental de uma escola municipal na zona sul de São Paulo
Authors: Lima Maria Zilda Alves , Fuentes Hazel Yvette , Souza Alessandra Mira de , Salgueiro Marcia Maria Hernandes de Abreu de Oliveira
Published: August 2019

Adolescentes; Conhecimento; Educação nutricional.
Insegurança alimentar de beneficiários do Programa de Assistência às Crianças Carentes com Alergia e Intolerância Alimentar no Maranhão
Authors: Sodré Luiz Eduardo de Andrade , Carvalho Carolina Abreu de , Fonsêca Poliana Cristina de Almeida , Monteiro Silvio Gomes , Conceição Sueli Ismael Oliveira da
Published: August 2019

Segurança Alimentar e Nutricional; Política Nutricional; Criança.
Perfil de resistência de Pseudomonas aeruginosa provenientes de água superficial e efluente hospitalar: teste de sensibilidade a antimicrobianos e detecção de metalo-β-lactamase
Authors: Silva Júnior Samuel de Alcântara , Baraúna Letícia , Santos Geiza Almeida Louredo dos , Pagung Elaine , Carvalho Pascua Leonardi , Freire Sigrid Costa Valbão , Moraes Rodrigo , Santos Rodrigo Pratte
Published: August 2019

Águas de superfície; Pseudomonas aeruginosa; Resistência a Múltiplos Medicamentos.
Política nacional e contexto local: a implementação da política de saúde bucal em uma capital brasileira
Authors: Contarato Priscilla Caran , Machado Cristiani Vieira
Published: August 2019

Saúde Bucal, Políticas Públicas, Integralidade em Saúde Política Nacional de Saúde Bucal; Centro de Especialidades Odontológicas.
Efeitos das terapias combinadas ultrassom + Corrente Aussie e ultrassom + Corrente Estereodinâmica no tratamento de gordura abdominal: estudo de casos
Authors: Costa Raíssa Biff , Garcez Valéria Ferreira , Da Silva Gleice Mara Aparecio , Cristofolli Laís , Panichella Eduardo Gusman , Nascimento Meg Caroline Afonso de Miranda do , Limana Mirieli Denardi
Published: August 2019

Gordura abdominal; Ultrassom; Terapêutica; Estética; Antropométrica.
Análise de dispositivos externos de acessibilidade nos serviços municipais de saúde: uma abordagem para deficientes físicos
Authors: Batistão Guilherme Trindade , Chaves Mariana Dias , Gomes Jaime de Oliveira
Published: August 2019

Acesso aos serviços de saúde; Análise espacial; Pessoas com deficiência.
O docente de enfermagem e a Síndrome de Burnout: um panorama na Universidade Regional do Cariri
Authors: Luna Neto Raimundo Tavares de , Cavalcante Maria Luana Barreto , Correia Agnes Raque da Silva , Ferreira Natalia Bastos , Adami Fernando
Published: August 2019

Esgotamento Profissional; Docentes; Educação em Enfermagem.
O relevante papel da vigilância para assegurar a efetividade da fluoretação da água de abastecimento público
Authors: Esposti Carolina Dutra Degli , Frazão Paulo
Published: August 2019

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Escova alternativa confeccionada com fibra de Buriti
Authors: Pinheiro Carolina Leão , Tuma Carlos Eduardo da Silva Nossa
Published: August 2019

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Estado nutricional de crianças e adolescentes admitidos para internação em um hospital universitário
Authors: Silva Claudileide de Sá , Cabral Poliana Coelho , Galvão Silvana Frade , Diniz Alcides Silva , Arruda Ilma Kruze Grande de , Santos Cláudia Mota dos
Published: August 2019

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Uma análise narrativa da Judicialização da Saúde
Authors: Freitas Beatriz Cristina de , Meneghim Marcelo de Castro
Published: August 2019

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Conhecimento de uma equipe de enfermagem quanto aos riscos e manuseio do mercúrio
Authors: Nunes Karolini Zuqui , Barbiero Leticia Covre , Furier Lorena Barros , Fioresi Mirian
Published: August 2019

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Avaliação do serviço de testagem e aconselhamento em DST/HIV/AIDS na perspectiva do usuário
Authors: Silva Michel Platinir Ferreira da , Luna Izaildo Tavares , Bezerra Sara Taciana Firmino , Maia Carlos Colares , Moura Denizielle de Jesus Moreira , Pinheiro Patrícia Neyva da Costa
Published: August 2019

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Satisfação do usuário em relação aos serviços de saúde que prestam ações de controle da tuberculose no município de Vitória/ES
Authors: Negri Letícya dos Santos Almeida , Villa Tereza Cristina Scatena , Motta Maria Catarina Salvador , Zandonade Eliana , Prado Thiago Nascimento , Maciel Ethel Leonor Noia
Published: August 2019

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Avaliação de programas de saúde: um enfoque no Programa Saúde da Família
Authors: Galavote Heletícia Scabelo , Mattos Tânia Mara Cappi , Laignier Mariana Rabello
Published: August 2019

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Caracterização fitoquímica e atividade antimicrobiana de extratos de Solanum subinerme (Solanaceae)
Authors: Gonçalves Ana Paula Pereira , Vieira Gabriel de Deus , Cunha Príscila Naiara Araújo , Kissler Thaís Vanessa Leite , Hernández Anselmo Enrique Ferrer , Teles Carolina Bioni Garcia
Published: August 2019

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Manifestações bucais da anemia de células falciformes em gêmeos heterozigóticos
Authors: Gomes Ana Paula Martins , Ferreira Helena Carla Gomes , Guaré Renata de Oliveira , Gomes Ana Maria Martins
Published: August 2019

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Mortalidade de adolescentes por causas externas no estado do Paraná: análise de dados oficiais
Authors: Silva Marcos Martins da , Meschial William Campo , Oliveira Magda Lúcia Félix de
Published: August 2019

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Fatores relacionados à não doação de órgãos de potenciais doadores no estado de Sergipe, Brasil
Authors: Barreto Bruna Souza , Santana Rubia Janine Brandão , Nogueira Emília Cervino , Fernandez Benito Oliveira , Brito Fabiana Pereira Guimarães
Published: August 2019

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Disciplina Metodologia da Pesquisa Científica em Saúde na modalidade a distância: conteúdo, abordagem e avaliação
Authors: Lopes Vincent Beatriz Rodrigues , Martinez-Silveira Martha Silvia , Bastos Camacho Luiz Antonio
Published: August 2019

Assessment of a Research Methodology course via Distance Education
Síndorme do respirador bucal: a experiência clínica de profissionais de saúde de Vitória - ES
Authors: Sipolatti Karina , Dadalto Elaine Cristina Vargas
Published: August 2019

Respiração bucal; Prevençao e controle; Pré-escolar.
Proteínas Ósseas Morfogenéticas: aplicação no processo de reparação do complexo Dentina Polpa
Authors: Carvalho Lívia Reis , Silva Marcelo Filadelfo
Published: August 2019

Proteínas Ósseas Morfogenéticas; Dentina reparadora; Capeamento pulpar.
Assessment of the preferred restorative material – composite resin or ceramic – for anterior teeth restoration
Authors: Schünemann Fernanda Haverroth , Valmorbida Jonas Alberto , Bernardon Jussara Karina
Published: August 2019

Introduction and objective: To evaluate the perception of clinicians and undergraduate students concerning their preferences and experience in using composite resin and ceramic veneers to restore anterior teeth restorations. Material and methods: 60 participants including clinicians (n=30) and undergraduate students (n=30) volunteered for this study. The study consisted of two parts. Firstly, the participant answered questions about their use and possible failure of ceramic or composite resin for anterior teeth. In thesecond part, participants analyzed 3 photographs of the anterior smile and reported on the presence of healthy teeth or restored teeth, with composite resin or ceramic veneers. Results: For both groups, composite resin was frequently used over ceramic and the most important reported factor in this decision choice was the cost factor. Both groups presented a failure percentage higher than 50% for composite resin, and this percentage was higher forundergraduate students. In the visual analysis of the photographs, none of the participants identified all the restorations correctly. Conclusion: Composite resin is the most common material of choice for clinicians and undergraduate students. Distinguishing natural teeth from restored teeth has become increasingly difficult, despite the restorative material (composite resin or ceramic) used.
Comprehensive Analysis of the mRNA-lncRNA Co-expression Profile and ceRNA Networks Patterns in Chronic Hepatitis B
Authors: Chen Wenbiao , Lin Chenhong , Gong Lan , Chen Jianing , liang Yan , Zeng Ping , Diao Hongyan
Published: August 2019

Background:

Long non-coding RNAs (lncRNAs) are emerging as important regulators in
the modulation of virus infection by targeting mRNA transcription. However, their roles in chronic
hepatitis B (CHB) remain to be elucidated.

Objective:

The study aimed to explore the lncRNAs and mRNA expression profiles in CHB and asymptomatic
HBsAg carriers (ASC) and construct mRNA-lncRNA co-expression profile and ceRNA
networks to identify the potential targets of diagnosis and treatment in CHB.

Methods:

We determined the expression profiles of lncRNAs and mRNAs in CHB and ASC using
microarray analysis. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG)
pathway enrichment analyses were performed to explore their function. We also constructed coexpression,
cis-regulatory, and competing endogenous RNA (ceRNA) networks with bioinformatics
methods.

Results:

We identified 1634 mRNAs and 5550 lncRNAs that were differentially expressed between
CHB and ASC. Significantly enriched GO terms and pathways were identified, many of which were
linked to immune processes and inflammatory responses. Co-expression analysis showed 1196 relationships
between the top 20 up/downregulated lncRNAs and mRNA, especially 213 lncRNAs interacted
with ZFP57. The ZFP57-specific ceRNA network covered 3 lncRNAs, 5 miRNAs, and 17
edges. Cis-correlation analysis showed that lncRNA T039096 was paired with the most differentially
expressed gene, ZFP57. Moreover, by expending the clinical samples size, the qRT-PCR results
showed that the expression of ZFP57 and T039096 increased in CHB compared to ASC.

Conclusion:

Our study provides insights into the roles of mRNA and lncRNA networks in CHB, highlighting
potential applications of lncRNA-T039096 and mRNA-ZFP57 for diagnosis and treatment.
The Development of an Antimicrobial Contact Lens – From the Laboratory to the Clinic
Authors: Willcox Mark D.P. , Chen R. , Kalaiselvan P. , Yasir M. , Rasul R. , Kumar N. , Dutta D.
Published: August 2019

Contact lens wear is generally safe and provides excellent vision. However, contact lens wear is often associated with the risk of developing ocular surface infection and inflammation, and in severe cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been made to help reduce the incidence of infection and inflammation. This paper reviews the research progress from conception, through the laboratory and preclinical tests to the latest information on clinical testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that have been encountered. The journey has not always been linear or smooth, but has resulted in some of the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.
Molecular Docking Based Analysis to Elucidate the DNA Topoisomerase IIβ as the Potential Target for the Ganoderic Acid; A Natural Therapeutic Agent in Cancer Therapy
Authors: Sharma Kaushal K. , Singh Brijendra , Mujwar Somdutt , Bisen Prakash S.
Published: August 2019

Introduction:

Intermediate covalent complex of DNA-Topoisomerase II enzyme is the
most promising target of the anticancer drugs to induce apoptosis in cancer cells. Currently, anticancer
drug and chemotherapy are facing major challenges i.e., drug resistance, chemical instability
and, dose-limiting side effect. Therefore, in this study, natural therapeutic agents (series of
Ganoderic acids) were used for the molecular docking simulation against Human DNATopoisomerase
II beta complex (PDB ID:3QX3).

Methods:

Molecular docking studies were performed on a 50 series of ganoderic acids reported in
the NCBI-PubChem database and FDA approved anti-cancer drugs, to find out binding energy, an
interacting residue at the active site of Human DNA-Topoisomerase II beta and compare with the
molecular arrangements of the interacting residue of etoposide with the Human DNA topoisomerase
II beta. The autodock 4.2 was used for the molecular docking and pharmacokinetic and toxicity
studies were performed for the analysis of physicochemical properties and to check the toxicity effects.
Discovery studio software was used for the visualization and analysis of docked pose.

Results and Conclusion:

Ganoderic acids (GS-1, A and DM) were found to be a more suitable
competitor inhibitor among the ganoderic acid series with appropriate binding energy, pharmacokinetic
profile and no toxicity effects. The interacting residue (Met782, DC-8, DC-11 and DA-12)
shared a chemical resemblance with the interacting residue of etoposide present at the active site of
human topoisomerase II beta receptor.
Electrochemical Polymerised Graphene Paste Electrode and Application to Catechol Sensing
Authors: Manjunatha Jamballi G.
Published: August 2019

Objective:

To build up an advantageous strategy for sensitive determination of catechol (CC), a poly (proline) modified graphene paste electrode (PPMGPE) was fabricated and used as a voltammetric sensor for the determination of CC.

Methods:

The performance of the modified electrode was studied using cyclic voltammetric (CV) and differential pulse voltammetric method (DPV). The modified electrode was characterized by CV and DPV. The surface of the modified electrode was examined by FESEM. The electrochemical behavior of CC in phosphate buffer solution (pH 7.5) was inspected using bare graphene paste electrode (BGPE) and PPMGPE.

Results & Conclusion:

The PPMGPE shows a lower limit of detection, calculated to be 8.7×10–7mol L−1 (S/N=3). This modified electrode was applied successfully for the determination of CC in water samples without applying any sample pretreatment.
Prevalence of Early Childhood Caries in Children Aged 1 to 5 Years in the City of Quito, Ecuador
Authors: C. Acuña Jenny E. , S. Freitas Karina M. , Henriques Rafael P. , Cruz Emerson F. , Ordóñez Maria C. R Binz , C. Arias Ghenna E. , A. Balseca Guillermo M.
Published: August 2019

Background:

Early childhood caries is an aggressive pathology that can destroy the teeth in a short time, reaching the proximal surfaces, causing discomfort, pain and affecting the dental pulp, causing premature loss of deciduous teeth.

Objective:

The purpose of this research is to determine the prevalence of early childhood caries in children aged 1 to 5 years of the Metropolitan District of Quito.

Materials and Methods:

This is a cross-sectional study including a sample of 557 children attending child care centers in Quito, Ecuador, between May and July 2018. The sample was evaluated clinically registering the data in a simplified dental file containing the odontogram and the result of decayed, lost and sealed teeth, according to the dmft index, as well as data such as age and gender. Data were tabulated and analyzed statistically by independent t-test.

Results:

The prevalence of early childhood caries was found to be 59.61%. Children affected by early childhood caries presented a mean age of 2.83 years, the ones suffered the most from this pathology were those of 2 years (35.54%), followed by those of 3 years (34.94%) and 4 years (22.5%). Boys presented more early childhood caries (53.92%) in relation to the girls (46.08%).

Conclusion:

The early childhood caries presented a prevalence of 59.61% and a general dmft index of medium level of severity according to the classification of the World Health Organization, in children from 1 to 5 years of age in Quito, Ecuador.
Antibacterial Activity of Phytochemical Extracts and Endophytic Fungi of Carapa Guianensis Against Enterococcus Faecalis in Endodontic Infections An In Vitro Study
Authors: de Miranda Maria do Carmo M. , Carvalho Clarice M. , Faria Fernando S.E.D.V. , Nobreza Antonio M-S. , Pereira Thiago M. , Pivatto Keliin , da Costa Marcus V.C. , Guedes Orlando A. , de Araújo Estrela Cyntia R. , Borges Álvaro H.
Published: August 2019

Objective:

The objective of this study was to evaluate the antibacterial activity of phytochemical extracts and endophytic fungi of Carapa guianensis against Enterococcus faecalis. Carapa guianensis leaves and stems were collected to obtain phytochemical extracts and fungal metabolites and evaluated for in vitro antibacterial activity against E. faecalis using the disc diffusion method and dentin blocks with bacterial biofilm.

Methods:

Thirty dentin blocks were prepared and contaminated for 60 days with E. faecalis. The specimens were randomly divided into 6 experimental groups according to the test solution used: G1 – hexane stem extract of Carapa guianensis; G2 – methanol stem extract of Carapa guianensis; G3 – methanol leaf extract of Carapa guianensis; G4 – ethyl acetate extract of the endophytic fungus Penicillium isolated from Carapa guianensis; G5 – negative control, with no addition of bacterial inoculum; G6 – positive control.

Results:

Bacterial growth was analyzed by spectrophotometry after 14 days of direct contact between the extracts and dentin blocks. The hexane-stem, methanol-stem, methanol-leaf, and ethyl-acetate endophytic fungus Penicillium extracts inhibited bacterial growth in 100% of the samples.

Conclusion:

The present study demonstrated the antibacterial potential of phytochemical extracts and endophytic fungi of Carapa guianensis against E. faecalis.
Double Whammy: Pigment Nephropathy and Warfarin-related Nephropathy As Aetiology for Acute Kidney Injury in a Patient With Mechanical Heart Valves
Authors: Conjeevaram Arvind , Lohia Priyangani , GS Ravishankar , Vankalakunti Mahesha
Published: August 2019

It is well known that patients with mechanical heart valves may develop sheer stress related hemolysis and consequent pigment related nephropathy. Warfarin Related Nephropathy (WRN) is a relatively new entity and defined as Acute Kidney Injury (AKI) in the setting of an INR of > 3.0 excluding other obvious etiologies. A biopsy diagnosis of WRN is conducted when red blood cell casts are noted filling and blocking the tubules; additionally, glomerular hemorrhage may be observed. We describe a patient with mechanical heart valves on oral anticoagulation who developed both pigment nephropathy and WRN causing AKI.
A Case of Multiple Wasp Stings Causing Multi-organ Dysfunction Syndrome
Authors: Basnet Nabin , Pantha Binod , Acharya Sanjeev , Shrestha Barsha , Kafle Rishi
Published: August 2019

Wasp stings occur commonly and uncomplicated cases are generally managed at local health centers. Complicated cases are referred to tertiary hospitals for multi-specialty care. We report a case of a 30-year old gentleman from a remote center in Nepal who had multiple wasp stings and developed oligo-anuric acute kidney injury, liver failure, and rhabdomyolysis. He was promptly referred to our hospital after initial resuscitation. At our hospital, he was treated with intensive conventional supportive care and specific organ-supportive care including N-Acetylcysteine infusion and hemodialysis. With the treatment given, the general condition of the patient as well as liver function improved within the first week. However, the recovery of kidney function and urine output lagged behind. The patient showed signs of improvement in kidney function at the end of the third week and completely recovered by the 40thday of treatment.
Genetic Characterization of Pepino Mosaic Virus Isolates from Morocco
Authors: Souiri Amal , Zemzami Mustapha , Laatiris Hayat , Amzazi Saaid , Ennaji Moulay M.
Published: August 2019

Introduction:

Throughout the past few years, Pepino Mosaic Virus (PepMV) has rapidly evolved from an emerging virus to endemic pathogen that causes significant losses in tomato crops worldwide. Reliable detection and molecular characterization are very important tools to support disease control. Cross-protection can also be an effective strategy, but the efficacy depends strongly on the genotype. The genetic composition of the PepMV population in Morocco has not yet been determined.

Aims:

The current study aims to genetically characterize twelve PepMV isolates (PepMV-MA), all from different Moroccan tomato production areas, by analyzing nucleotide sequences of a part of the RNA-dependent RNA polymerase (RdRp), Triple Gene Block (TGB) and Coat Protein (CP) genes.

Results:

The sequence analysis of the twelve PepMV-MA isolates shows minor nucleotide differences between them, which implies a homogenous population. The phylogenetic analysis, based on the comparison with the major genotypes, showed that Moroccan PepMV populations share a very high sequence identity, 98%, with the Chilean strain (CH2), while the shared identity with the European strains (EU) is only 85%. Interestingly, Moroccan isolates reveal specific single nucleotide polymorphisms, some of which lead to amino acids changes. These mutations have never been described before, suggesting distinct variants that may enhance aggressiveness and symptomatology.

Conclusion:

Our careful sequence analysis and genotype determination, which placing homogenous Moroccan PepMV strains into CH2 genotype, would be a prerequisite for deploying effective cross-protection strategies for controlling the pathogen in the field.
Current Mode and Voltage Mode Third Order Sinusoidal Oscillator Using CCDDCCTA
Authors: Kushwaha Ajay K. , Kumar Ashok , Pareek Prakash
Published: August 2019

Objective:

In this paper, a novel third order sinusoidal oscillator based on current
controlled differential difference current conveyor transconductance amplifier (CCDDCCTA) is
proposed.

Methods:

The proposed circuit configuration consist of single CCDDCCTA, two grounded resistor
and three capacitors. It can concurrently yield output voltage and current. The amplitude of output
current can be easily tuned by the bias current. The non-ideality and Monte-Carlo analysis are discussed
and presented.

Results:

The stated results agree well with the theoretical estimation.

Conclusion:

The performance ofa proposed oscillator are analyzed with ORCAD 16.6 simulator
and the analog block has been depicted using 0.25 μm CMOS TSMC technology parameters.
Phosphonate Derivatives of 3,5-bis(arylidene)-4-piperidone: Synthesis and Biological Evaluation
Authors: Mishra Shweta , Das Debashree , Sahu Adarsh , Patil Shailendra , Agrawal Ram Kishore , Gajbhiye Asmita
Published: August 2019

Background:

3,5-Bis(arylidene)-4-piperidinones (BAP) belong to a wide class of cross
conjugated dienones. The 1,5-diaryl-3-oxo-1,4-pentadienyl fragment of the BAP moiety is responsible
for the molecule's anti-tumor, antioxidant, antimicrobial and anti-inflammatory manifestations.
In the present study, we present combinations of phosphonate and 3,5-bis(arylidene)-4-
piperidone pharmacophores. The anti-inflammatory, anti-oxidant potential, anti-proliferative, cytotoxic
potential and antimicrobial of the title compounds were evaluated in in-vitro bioassay paradigms.

Methods:

A novel class of phosphonate linked 3,5-Bis(aryl methylene)-4-piperidone derivatives
were synthesized from simple, versitalie and efficient synthetic methodology. All of the synthesized
compounds were screened for their in vitro anti-inflammatory, in vitro anti-oxidant potential,
in vitro anti-proliferative, in vitro cytotoxic potential and in vitro antimicrobial activity. Amongst
all the synthesized compounds in series, phosphonate derivatives of 3,5-Bis(arylmethylene)-4-
piperidone containing 4-hydroxy-3-methoxyphenyl curcumin like prototype were more active than
phenyl substituted compounds.

Results:

The results of the screening revealed that compounds 5e, 5f, 5g, 5h were more active candidates
as compared to 5a, 5b, 5c and 5d, however 5d can be readily endorsed as the most active
compound of the series. Structure- activity relationship of the synthesized series suggested that
structural resemblance of the synthesized compounds with that of curcumin was enormously accountable
for the compounds anti-inflammatory, antioxidant and cytotoxic potential activity.

Conclusion:

The in-vitro biological spectrum indicated that the substitution of groups at third and
fourth position and alkyl phosphonates substitution potentiates the activity as compared to curcumin.
Herbal Medications for the Management of Diabetes Mellitus: A Review
Authors: Al-Jaidi Bilal A. , Odetallah Haifa'a Marouf , Chandrasekaran Balakumar , Amro Razan
Published: August 2019

Diabetes mellitus is a chronic metabolic disorder of the endocrine system affecting people worldwide. It is a serious disorder that needs lifetime control which is mainly treated by numerous chemical agents. Most of these chemical agents are associated with various unpleasant adverse effects, as a result of which there is a growing interest towards the alternative medicines which are found to be comparatively safer causing less adverse effects. As there are many plant’s extracts which are evident to provide hypoglycemic effect, intensive investigations are under progress to explore their advantageous effects on diabetic patients. This article discusses some of these important plants that are either being used for diabetes treatment or under investigation for future drug development.
Research Progress of Photocatalytic Deep Denitrification Technology for Oil Products: Mini-review
Authors: Chen Ying , Zhang HuilLi , Liang YuNing
Published: August 2019

Due to the presence of nitrides in oil, the stability, storage and transportation safety
and deep processing of oil are affected. In recent years, denitrification of oil products has become
one of the research hotspots for solving environmental pollution and energy shortages.
Modified nanoparticles are important photocatalytic material because they have indicated improvement
in the performance as compared with other technologies when they are used for
denitrification. There are mainly three kinds of modified nanoparticles applied in the field of
photocatalytic denitrification, including titanium catalyst, bismuth catalyst and others. The research
on photocatalyst denitrification has been promoted by the advancement of science and
technology. This article focuses on the development process, research status and catalytic
mechanism of photocatalytic technology in the field of denitrification. In addition, it provides
guidance for the preparation of novel modified nanophotocatalysts for high-efficiency applications
in the field of denitrification of oils.
PENGEMBANGAN MEDIA EVALUASI PEMBELAJARAN SEJARAH BERBASIS ANDROID DI KELAS X SMK PENERBANGAN AAG ADISUTJIPTO
Authors: Setiawan Veri , Izmi Kusumawijaya Rizal
Published: August 2019

ABSTRAKTeknologi informasi dan komunikasi merupakan salah satu bidang yang berkembang pesat saat ini. Berbagai macam inovasi baru dikembangkan oleh para ahli. Pada penelitian ini, peneliti bertujuan untuk (1) mengembangkan media evaluasi pembelajaran sejarah berbasis android; (2) mengetahui efektifitas penggunaan media evaluasi pembelajaran sejarah berbasis android pada siswa kelas X SMK Penerbangan AAG Adisutjipto. Penelitian ini menggunakan model Addie oleh Molenda yang terdiri dari lima tahapan; (1) Analisis; (2) Desain; (3) Pengembangan; (4) Implementasi dan (5) Evaluasi. Hasil penelitian menunjukan kelayakan Media Evaluasi Pembelajaran Sejarah menurut ahli media diperoleh 92,3% dan termasuk dalam kategori sangat layak dan menurut ahli materi diperoleh 74% dan termasuk dalam kategori layak. Pada uji coba terbatas diperoleh persentase 82,6% dan termasuk dalam kategori sangat layak, pada Uji luas diperoleh persentase 80,5% dan termasuk dalam kategori sangat layak.  Kata Kunci: Android, media evaluasi, sejarah ABSTRACT             Information and communication technology is one of the most advanced fields today. Various new innovations come from the results of the development of the experts. In this research, the researchers aimed: (1) to produce history evaluation media based on android; (2) to know the effectiveness of the use of history evaluation media based on android applications in class X SMK Penerbangan AAG Adisutjipto. This research using ADDIE model by Molenda’s that consists of five stages; (1) analysis model; (2) design model; (3) development; (4) implementation; and (5) evaluation. The research result showed that History Evaluation Media based On Android with feasibility level according to the assessment by media expert was obtained by 92,3% which was category of very feasible, and assessment by material experts was obtained by 74% which was category of feasible. The limited trial result obtained percentage by 82,6% which was category of very feasible. The result of extensive trial obtained percentage by 80,5% which was category of very feasible.  Keyword: Android, media evaluation, history
LUBUKLINGGAU'S ULU ALPHABET AND ITS PRESERVATION
Authors: Asmara Yeni
Published: August 2019

AbstrakAksara Ulu merupakan aksara yang digunakan oleh masyarakat daerah pesisir Sumatera yaitu etnis Pasemah, Serawai, Rejang, dan Lembak yang zaman dahulu difungsikan sebagai media dalam penyampaian nilai-nilai kearifan lokal, menceritakan suatu kisah, mencatat hukum adat, menulis sajak atau syair,  menyampaikan ajaran agama, pengobatan, ataupun petuah. Pengaruh budaya asing di era globalisasi saat ini, dapat menyebabkan adanya perubahan kebudayaan sehingga terjadinya degradasi budaya lokal seperti Aksara Ulu yang keberadaannya semakin hilang eksistensinya terutama di beberapa daerah salah satunya Kota Lubuklinggau. Aksara Ulu tidak begitu familier di kalangan masyarakat terlebih lagi para pelajar sebagai generasi muda yang seharusnya aksara tersebut perlu dilestarikan dan dikembangkan dengan melalui berbagai upaya seperti melalui sosialisasi dan pembelajaran baik lingkungan formal maupun informal dalam kehidupan masyarakat sehingga aksara tersebut keberadaannya akan terus bertahan karena masyarakat pendukungnya tetap konsisten dalam memfungsikan aksara ulu sebagai identitas lokal yang harus dilestarikan. Kata Kunci : Aksara Ulu, Pelestarian AbstractThe Ulu alphabet by the Sumatra coastal communities, namely the Pasemah, Serawai, Rejang, and Lembak ethnic groups, which is functioned as media in delivering local wisdom values, telling a story, recording customary law, writing poems or poetry, conveying the teachings of religion, medicine, or advice. The influence of foreign culture in the current era of globalization does not rule out the possibility of local cultural degradation such as Ulu alphabet whose existence is almost vanished, especially in some areas, one of which is in Lubuklinggau. Ulu alphabet is not very common for the public, especially for the students as the young generation who should have preserved the alphabet and developed it through various efforts such as the introduction of reading and writing Ulu alphabet both in formal and informal environments in people's lives so that they remain exist and not eroded by the current development of the world. Keywords: Ulu Alphabet, Preservation
Расчетно-экспериментальное моделирование обратимых сбоев ячеек статической памяти субмикронных микросхем при воздействии потоков нейтронов
Authors: Пузанов А.С. , Венедиктов М.М. , Оболенский С.В. , Козлов В.А.
Published: August 2019

AbstractThe simulation of reversible single events in test samples of static memory microcircuits with design norms of 0.5, 0.35, 0.25, and 0.1 μm under the effect of neutron fluxes with various energies is performed. It is shown theoretically and experimentally that reversible single events can occur in modern microelectronics and nanoelectronics products under the effect of a fission-spectrum neutron flux caused by the passage of primary recoil atoms and nuclear reaction products along the microcircuit surface perpendicularly to the electric current lines in the near-drain transistor area. A series of irradiation experiments of static memory circuits with design norms of 0.35 μm is interpreted based on the proposed model.
Исследования поперечного среза и фотолюминесценции слоя GaAs, выращенного на подложке Si/Al-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=-
Authors: Сушков А.А. , Павлов Д.А. , Шенгуров В.Г. , Денисов C.А. , Чалков В.Ю. , Байдусь Н.В. , Рыков А.В. , Крюков Р.Н.
Published: August 2019

AbstractA GaAs/AlAs/GaAs/AlAs/Ge heterostructure grown on a Si/Al_2O_3(1 $$\bar {1}$$ 02) substrate is formed and studied. The Ge buffer layer is produced by the “hot wire” technique, whereas the III–V layers are grown by metal–organic vapor-phase epitaxy. The optical quality of the III–V layers is determined by photoluminescence spectroscopy. Structural studies are performed by high-resolution transmission electron microscopy. The elemental composition is determined by energy-dispersive X-ray spectroscopy. In the study, the possibility of growing a single-crystal GaAs layer on a Si/Al_2O_3 substrate through AlAs/GaAs/AlAs/Ge buffer layers is shown.
Безызлучательный перенос энергии в гибридных наноструктурах с различной размерностью
Authors: Хребтов А.И. , Резник Р.Р. , Убыйвовк Е.В. , Литвин А.П. , Скурлов И.Д. , Парфёнов П.С. , Кулагина А.С. , Данилов В.В. , Цырлин Г.Э.
Published: August 2019

AbstractA composite nanostructure based on quasi-one-dimensional InP nanowires with an InAsP nanoinsert, grown on a Si(111) substrate by the method of molecular-beam epitaxy, and CdSe/ZnS zero-dimensional colloidal quantum dots is reported for the first time. The nonradiative resonance energy transfer between components of the hybrid nanostructure, namely, between the colloidal quantum dots and the nanoinsert, is experimentally confirmed.
Особенности нелинейного отклика структуры сверхпроводник-нормальный металл с большим отношением удельных сопротивлений
Authors: Пестов Е.Е. , Ноздрин Ю.Н. , Рогов В.В. , Пашенькин И.Ю. , Водолазов Д.Ю.
Published: August 2019

Using the method of near-field microwave microscopy, we investigated the temperature dependence
of the third harmonic power P3ω (T) of superconductor – normal metal MoN / Al structures
with proximity effect. The presence of an additional (low-temperature) maximum and
vanishing in the dependence P3ω (T) for the MoN / Al structure, which disappear
when a weak perpendicular magnetic field is applied.
Электронно-дырочные димеры в "родительской" фазе квази-2D-купратов
Authors: Москвин А.С. , Панов Ю.Д.
Published: August 2019

One of the most important features of the parent cuprates such as La2CuO4, which predetermines their unusual behavior under non-isovalent substitution, is high ionic polarizability and proximity to the «polarization catastrophe». We show that at the same time parent cuprates are characterized by a charge transfer instability with the formation of a system of metastable dipole-active «Mott-Hubbard» excitons, or electron-hole (EH) dimers. Non-isovalent substitution shifts the phase equilibrium in the direction of condensation of EH-dimers and the formation of an inhomogeneous EH-liquid, in the simplest model, equivalent to a system of composite bosons.
To effectively describe the electronic state of doped cuprates, it is proposed to use the S = 1 pseudospin formalism, which allows one to consider novel charge states of the Anderson RVB-type phase. The recombination of EH-dimers under a critically small value of the energy of local and nonlocal correlations leads to the transition of the system to the Fermi-liquid state.
Квантовый размерный эффект в сверхпроводящих пленках алюминия
Authors: Арутюнов К.Ю. , Седов Е.А. , Голоколенов И.А. , Завьялов В.В. , Константинидис Г. , Ставринидис А. , Ставринидис Г. , Василиадис И. , Кехагиас Т. , Димитракопулос Г.П. , Комнину Ф. , Кроитору М.Д. , Шаненко А.А.
Published: August 2019

High-quality aluminum films on GaAs substrates were experimentally studied. A noticeable increase in the critical temperature of the superconducting transition with a decrease in the film thickness was found. The effect is interpreted as manifestation of the quantum size effect, which affects both the density of electron states and the electron-phonon interaction.
МСМ исследование влияния механических напряжений на магнитное состояние частиц Ni
Authors: Ермолаева О.Л. , Гусев Н.С. , Скороходов Е.В. , Рогов В.В. , Удалов О.Г.
Published: August 2019

AbstractThe effect of strains on ferromagnetic particles has been studied. Arrays of Ni microparticles of different shapes on glass substrates have been fabricated. The magnetic state of the fabricated particles as a function of the degree of glass substrate bending has been investigated. It has been established that the ground state of unbent particles is vortex. It is shown that the substrate bending leads to the transition from the vortex to quasi-homogeneous state.
Микромагнитное моделирование спин-волновых возбуждений в гофрированных пленках ЖИГ
Authors: Сахаров В.К. , Хивинцев Ю.В. , Дудко Г.М. , Высоцкий С.Л. , Филимонов Ю.А.
Published: August 2019

Particularities of the spin-wave spectrum in YIG film with the thickness of 0.4 μm and magnetization of 1.1 kG that was corrugated due to the periodical substrate relief in the form of grooves having width of 10 μm, depth of 0.5 μm, sloped walls and period of 20 μm were studied with the help of micromagnetic modelling. Calculations were carried out for the external magnetic field applied along (θ=0) and across (θ=90°) the grooves in the film plane, and showed that the anisotropy from the film form caused the spectrum quantization and localization of spin-wave excitations in the different parts of the sample. Besides that, spacial distribution of magnetization amplitude at fixed frequencies in the spectrum for θ=90° can be characterized by several spacial scales that differ by orders. This is explained by the strong inhomogeneity of equilibrium state at grooves' walls for θ=90° that leads to the effective excitation of short-wave part of the spin-wave spectrum in the periodical structure by Schlömann mechanism.