bluuebunny/crossref_metadata_2025 huggingface dataset:
Policy scenario analysis of achieving the "dual carbon" goal for the road transportation sector in China
Authors: He Ling-Yun , Yang Shuang
Published: March 2024

The goal of "dual carbon" has brought the pressure of reducing carbon emissions to the road transportation sector in China. This study aims to identify and analyze possible policy measures that would help to achieve this goal from the perspective of the whole life cycle. We build a bottom-up computing framework based on the LEAP model. Six policy scenarios are designed to quantitatively assess their effects. The results show that promoting pure electric vehicles (PEV) and plug-in hybrid electric vehicles (PHEV) is appropriate for the passenger vehicles (PV), light-duty trucks (LDT), and mini trucks (MT) sub-sectors, while hydrogen fuel cell vehicles (FCV) are more suitable for the promotion of the heavy-duty trucks (HDT), heavy-duty buses (HDB), and medium-duty buses (MDB) sub-sectors. Additionally, the recycling of vehicle materials can effectively reduce the carbon emissions during the life cycle of motor vehicles. Furthermore, reducing the carbon emissions from the vehicle cycle of PV and the fuel cycle of HDT should be taken seriously. The main contribution of this study lies in establishing a comprehensive list of vehicle cycle carbon emission factors, covering various sub-sectors of China's road transportation sector. Besides, this study considers China's strategic planning and "dual carbon" goal, and proposes policy recommendations specifically tailored to the practical issues faced by China.
Stopping Gender-Based Violence and Harassment at Work
Authors: Pillinger Jane , Runge Robin R. , King Chidi
Published: March 2024

Women across the world experience gender-based violence and harassment in the workplace. In the context of globalization and neoliberalism, work plays an important role in constructing and maintaining the economic, social and cultural systems of oppression that women face. Women in insecure, precarious employment and women not protected by trade unions are the most at risk of violence and as the #MeToo movement has shown, it stretches across societies rich and poor.

In June 2019, the International Labour Organization adopted a ground-breaking global treaty on eliminating violence and harassment in the world of work. This historic vote was the result of more than a decade of campaigning and lobbying by women trade union leaders and their allies across the world. Chidi King, Robin Runge and Jane Pillinger played a key role in the campaign and the negotiation of the Convention. Combining both their activist and academic backgrounds, this book documents their unique insights into and experience of the campaign and its landmark achievement in international labour law, global policy and the cross-movement building of workers' and women's rights, which has reignited the role of trade unions, and particularly women in trade unions, in global advocacy.
Xiconomics
Authors: Cainey Andrew , Prange Christiane
Published: March 2024

Matters of ideology and security have become deeply entwined in China's economic and business environment. The context is more politicized, more uncertain. At the heart of Xiconomics is the Dual Circulation Strategy, which marks out clear dividing lines between China's domestic economy and the rest of the world. It sets out how China seeks to manage the links between the two just when western countries are also focusing on decoupling and 'friendshoring'. In order to prosper, business leaders and policy-makers need to understand these new international dynamics.

In this concise and incisive analysis, Andrew Cainey and Christiane Prange explain what is happening in China and how this affects its relations with other countries. They identify what foreign companies need to do, how strategies need to change, and what this all means for managing the China business as part of a global portfolio, under a range of geopolitical scenarios.
Resources needed by critical access hospitals to address identified infection prevention and control program gaps
Authors: Soma Mounica , Scebold Jody , Vasa Angela , Fitzgerald Teresa Ann , Tyner Kate , Lalam Satya Kumar , Beach Sue , Ashraf Muhammad Salman
Published: March 2024

Objective:

The study examined resources needed by Infection Preventionists (IP) to address infection prevention and control (IPC) program gaps.

Design:

A 49-question survey.

Setting:

Licensed Critical Access Hospitals (CAHs) in Federal Emergency Management Area (FEMA) Region VII.

Participants:

IP at licensed CAHs.

Methods:

The survey conducted between December 2020 and January 2021 consisted of questions focusing on four categories including IPC program infrastructure, competency-based training, audit and feedback, and identification of high-risk pathogens/serious communicable diseases (HRP/SCD). An IPC score was calculated for each facility by totaling “Yes” responses (which indicate best practices) to 49 main survey questions. Follow-up questions explored the resources needed by the CAHs to implement or further strengthen best practices and mitigate IPC practice gaps. Welch t-test was used to study differences in IPC practice scores between states.

Results:

50 of 259 (19.3%) CAHs participated in the survey with 37 (14.3%) answering all 49 questions. CAHs responding to all questions had a median IPC score of 35. There was no significant difference between IPC practice scores of CAHs in NE and IA. The top three IPC gaps were absence of drug diversion program (77%), lack of audits and feedback for insertion and maintenance of central venous catheters (76%), and missing laboratory risk assessments to identify tests that can be offered safely for patients under investigation for HRP/SCD (76%). Standardized audit tools, educational resources, and staff training materials were cited as much-needed resources.

Conclusion:

IPC practice gaps exist in CAHs. Various resources are needed for gap mitigation.
Domain adaptation with transfer learning for pasture digital twins
Authors: Pylianidis Christos , Kallenberg Michiel G.J. , Athanasiadis Ioannis N.
Published: March 2024

Domain adaptation is important in agriculture because agricultural systems have their own individual characteristics. Applying the same treatment practices (e.g., fertilization) to different systems may not have the desired effect due to those characteristics. Domain adaptation is also an inherent aspect of digital twins. In this work, we examine the potential of transfer learning for domain adaptation in pasture digital twins. We use a synthetic dataset of grassland pasture simulations to pretrain and fine-tune machine learning metamodels for nitrogen response rate prediction. We investigate the outcome in locations with diverse climates, and examine the effect on the results of including more weather and agricultural management practices data during the pretraining phase. We find that transfer learning seems promising to make the models adapt to new conditions. Moreover, our experiments show that adding more weather data on the pretraining phase has a small effect on fine-tuned model performance compared to adding more management practices. This is an interesting finding that is worth further investigation in future studies.
On the Turán number of the hypercube
Authors: Janzer Oliver , Sudakov Benny
Published: March 2024

In 1964, Erdős proposed the problem of estimating the Turán number of the d-dimensional hypercube

$Q_d$

. Since

$Q_d$

is a bipartite graph with maximum degree d, it follows from results of Füredi and Alon, Krivelevich, Sudakov that

$\mathrm {ex}(n,Q_d)=O_d(n^{2-1/d})$

. A recent general result of Sudakov and Tomon implies the slightly stronger bound

$\mathrm {ex}(n,Q_d)=o(n^{2-1/d})$

. We obtain the first power-improvement for this old problem by showing that

$\mathrm {ex}(n,Q_d)=O_d\left (n^{2-\frac {1}{d-1}+\frac {1}{(d-1)2^{d-1}}}\right )$

. This answers a question of Liu. Moreover, our techniques give a power improvement for a larger class of graphs than cubes.

We use a similar method to prove that any n-vertex, properly edge-coloured graph without a rainbow cycle has at most

$O(n(\log n)^2)$

edges, improving the previous best bound of

$n(\log n)^{2+o(1)}$

by Tomon. Furthermore, we show that any properly edge-coloured n-vertex graph with

$\omega (n\log n)$

edges contains a cycle which is almost rainbow: that is, almost all edges in it have a unique colour. This latter result is tight.
On the behaviour of the upstream-travelling waves in merging twin-jet systems
Authors: Stavropoulos Michael N. , Martini Eduardo , Edgington-Mitchell Daniel M. , Weightman Joel , Jordan Peter , Nogueira Petrônio A.S.
Published: March 2024

There is currently considerable interest in the guided-jet mode, as a result of recent works demonstrating it being the upstream component of various resonant systems in high-speed flows. For given jet operating conditions, the mode is known to exist over only a finite-frequency range that, for a twin-jet system, has been observed to vary with both jet separation and solution symmetry. Vortex-sheet and finite-thickness linear stability models are here employed to consider the behaviour of the guided-jet mode as the two jets are brought together, for both a planar and round twin-jet system. It is demonstrated that in both cases as the twin-jet system merges it forms a higher-order mode of an equivalent single-jet geometry. This then imposes a constraint on the guided-jet mode as the finite-frequency range must change to meet that of the equivalent geometry the system merges to, explaining the previously observed dependence on jet separation.
The role of consciousness in Chinese nominal metaphor processing: a psychophysical approach
Authors: Cheng Kaiwen , Chen Yu , Yan Hongmei , Wang Ling
Published: March 2024

Conceptual metaphor theory (CMT) holds that most conceptual metaphors are processed unconsciously. However, whether multiple words can be integrated into a holistic metaphoric sentence without consciousness remains controversial in cognitive science and psychology. This study aims to investigate the role of consciousness in processing Chinese nominal metaphoric sentences ‘A是B’ (A is[like] B) with a psychophysical experimental paradigm referred to as breaking continuous flash suppression (b-CFS). We manipulated sentence types (metaphoric, literal and anomalous) and word forms (upright, inverted) in a two-staged experiment (CFS and non-CFS). No difference was found in the breakthrough times among all three types of sentences in the CFS stage, while literal sentences were detected more slowly than either metaphoric or anomalous sentences in the non-CFS stage. The results suggest that the integration of multiple words may not succeed without the participation of consciousness, let alone metaphoric processing. These findings may redefine ‘unconscious’ in CMT as ‘preconscious’ and support the indirect access view regarding how the metaphoric meaning is processed in the brain.
‘A sad inheritance of misery’: the cultural life of hereditary scrofula in eighteenth-century England
Authors: Gallagher Noelle Dückmann
Published: March 2024

This essay argues that scrofula was one of several disorders, including gout, rickets, and venereal disease, that were ‘rebranded’ as hereditary in response to broader cultural changes that took place during the Restoration and eighteenth century in England. While the purposes of scrofula’s recategorisation were more political than medical, they resulted in this heretofore relatively obscure childhood ailment assuming a new prominence within both medical and popular discourses of the period. Scrofula became both emblem and proof of the links between sexual promiscuity, financial profligacy, and physiological degeneration, its symbolic status reinforced by the legal and moral language used to model processes of hereditary transmission. By likening the inheritance of scrofula to the inheritance of original sin—or, more commonly, to the inheritance of a ‘docked entail’ or damaged estate—eighteenth-century writers and artists not only made this non-inherited ailment into a sign of catastrophic hereditary decline; they also paved the way for scrofula to be identified as a disease of aristocratic vice, even though its association with crowded, unsanitary living conditions likely made it more common among the poor. By the same token, financial models of disease inheritance facilitated a bias toward paternal transmission, with scrofula often portrayed as passing, like a title or an estate, from father to son rather than from mother to daughter.
L2 to Lp bounds for spectral projectors on the Euclidean two-dimensional torus
Authors: Demeter Ciprian , Germain Pierre
Published: March 2024

We consider spectral projectors associated to the Euclidean Laplacian on the two-dimensional torus, in the case where the spectral window is narrow. Bounds for their L2 to Lp operator norm are derived, extending the classical result of Sogge; a new question on the convolution kernel of the projector is introduced. The methods employed include $\ell^2$ decoupling, small cap decoupling and estimates of exponential sums.
Coping self-efficacy mediates effects of posttraumatic distress on communal coping in parent-adolescence dyads after floods
Authors: Shoji Kotaro , Benight Charles C. , Afifi Tamara , Felix Erika D.
Published: March 2024

Social cognitive theory provides a framework of human agency during environmental challenges, with coping self-efficacy (CSE) as an important construct underlying adaptation. We examined two alternative models involving CSE as a mediator of the association between posttraumatic stress symptoms (PTSS) and communal coping among parent-youth dyads after severe floods using Bayesian dyadic multilevel modeling. The first model included PTSS as the independent variable and communal coping as the dependent variable (disaster distress model). The independent and dependent variables were replaced for each other in the second model (communal coping model). We used data from 485 parent-youth dyads who experienced floods between 2015 and 2016 in Texas, USA. Parents of children (69% women) aged 10–19 years old, and their oldest child (53% male; Mean age = 13.75) in that age range were recruited. We assessed PTSS, CSE, and communal coping for parents and youths. Results favored the disaster distress model over the communal coping model. In the disaster distress model, results demonstrated that CSE declines as PTSS increases, predicting decreased communal coping. This mediation effect of CSE is stronger for youths compared to parents, indicating that children’s CSE is affected more by PTSS.
Dhikr and Qur’an Recitation Therapy: An Idea to Recover the Mental Health of Families of the Death Victims of Mount Marapi Eruption in West Sumatra, Indonesia
Authors: Pohan Rizky Andana , Marimbun Marimbun , Chalidaziah Wan , Ramadhani Erfan , Putri Ramtia Darma , Laras Palasara Brahmani
Published: March 2024

Background:

Volcanic eruption is one of the most common disasters in Indonesia. One of the most fatal volcanic eruptions in Indonesia in 2023 was the eruption of Mount Marapi in West Sumatra. This caused a psychological impact on the survivors and families of the victims who died.

Problem:

Psychological interventions are usually only provided to survivors. It is very rare to find psychosocial assistance provided to the families of victims who died, even though they also experience acute and prolonged mental health disorders, such as trauma and even depression. So, we offer the idea of remembrance therapy and reading the Qur’an to restore the mental health of the families of the deceased victims.

Conclusion:

Dhikr and Qur’an recitation therapy fosters sincerity, patience, and self-acceptance so as to restore mental health in the families of the victims of the Mount Marapi eruption. The therapy serves as a calming factor for the soul because it contains various wisdoms for the calamities experienced. The whole series of therapy is closed with prayer as a form of surrendering the soul to God.
THERMODYNAMIC FORMALISM FOR AMENABLE GROUPS AND COUNTABLE STATE SPACES
Authors: Beltrán Elmer R. , Bissacot Rodrigo , Borsato Luísa , Briceño Raimundo
Published: March 2024

Given the full shift over a countable state space on a countable amenable group, we develop its thermodynamic formalism. First, we introduce the concept of pressure and, using tiling techniques, prove its existence and further properties, such as an infimum rule. Next, we extend the definitions of different notions of Gibbs measures and prove their existence and equivalence, given some regularity and normalization criteria on the potential. Finally, we provide a family of potentials that nontrivially satisfy the conditions for having this equivalence and a nonempty range of inverse temperatures where uniqueness holds.
PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation
Authors: Penack Olaf , Abouqateb Mouad , Peczynski Christophe , Boreland William , Gülbas Zafer , Gedde-Dahl Tobias , Castilla-Llorente Cristina , Kröger Nicolaus , Eder Mathias , Rambaldi Alessandro , Bonifazi Francesca , Blau Igor Wolfgang , Stelljes Matthias , Dreger Peter , Moiseev Ivan , Schoemans Hélène , Koenecke Christian , Peric Zinaida
Published: March 2024

There is an increased risk of GVHD and of non-relapse mortality (NRM) after allogeneic stem cell transplantations (alloSCT) when mismatched unrelated donors (MMUD) are used. In Europe, it is standard practice to use rabbit anti-thymocyte globulin (rATG) to reduce the high NRM and GVHD risks after MMUD alloSCT. As an alternative to rATG, post-transplantation Cyclophosphamide (PTCy) is in increasing clinical use. It is currently impossible to give general recommendations regarding preference for one method over another since comparative evidence from larger data sets is lacking. To improve the evidence base, we analyzed the outcome of rATG vs. PTCy prophylaxis in adult patients with hematologic malignancies undergoing first peripheral blood alloSCT from MMUD (9/10 antigen match) between Jan 2018 and June 2021 in the database of the European Society for Blood and Marrow Transplantation (EBMT). We performed multivariate analyses using the Cox proportional-hazards regression model. We included 2123 patients in the final analyses (PTCy, n = 583; rATG, n = 1540). p values and hazard ratios (HR) presented here are multivariate outcomes. Two years after alloSCT we found a lower NRM in the PTCy group of 18% vs. 24.9% in the rATG group; p = 0.028, HR 0.74. Overall survival in the PTCy cohort was higher with 65.7% vs. 55.7% in the rATG cohort; p < 0.001, HR 0.77. Progression-free survival was also better in the PTCy patients with 59.1% vs. 48.8% when using rATG; p = 0.001, 0.78. The incidences of chronic GVHD and acute GVHD were not significantly different between the groups. We found significantly lower NRM as well as higher survival in recipients of peripheral blood alloSCTs from MMUD receiving PTCy as compared to rATG. The results of the current analysis suggest an added value of PTCy as GVHD prophylaxis in MMUD alloSCT.
TGF-β-driven LIF expression influences neutrophil extracellular traps (NETs) and contributes to peritoneal metastasis in gastric cancer
Authors: Zhang Fangbin , Yan Yan , Cao Xinguang , Guo Changqing , Wang Ke , Lv Shuai
Published: March 2024

Gastric cancer (GC), notorious for its poor prognosis, often advances to peritoneal dissemination, a crucial determinant of detrimental outcomes. This study intricately explores the role of the TGFβ-Smad-LIF axis within the tumor microenvironment in propagating peritoneal metastasis, with a specific emphasis on its molecular mechanism in instigating Neutrophil Extracellular Traps (NETs) formation and encouraging GC cellular functions. Through a blend of bioinformatics analyses, utilizing TCGA and GEO databases, and meticulous in vivo and in vitro experiments, LIF was identified as pivotally associated with GC metastasis, notably, enhancing the NETs formation through neutrophil stimulation. Mechanistically, TGF-β was substantiated to elevate LIF expression via the activation of the Smad2/3 complex, culminating in NETs formation and consequently, propelling peritoneal metastasis of GC. This revelation uncovers a novel potential therapeutic target, promising a new avenue in managing GC and mitigating its metastatic propensities.
A citric acid cycle-deficient Escherichia coli as an efficient chassis for aerobic fermentations
Authors: Zhou Hang , Zhang Yiwen , Long Christopher P. , Xia Xuesen , Xue Yanfen , Ma Yanhe , Antoniewicz Maciek R. , Tao Yong , Lin Baixue
Published: March 2024

Tricarboxylic acid cycle (TCA cycle) plays an important role for aerobic growth of heterotrophic bacteria. Theoretically, eliminating TCA cycle would decrease carbon dissipation and facilitate chemicals biosynthesis. Here, we construct an E. coli strain without a functional TCA cycle that can serve as a versatile chassis for chemicals biosynthesis. We first use adaptive laboratory evolution to recover aerobic growth in minimal medium of TCA cycle-deficient E. coli. Inactivation of succinate dehydrogenase is a key event in the evolutionary trajectory. Supply of succinyl-CoA is identified as the growth limiting factor. By replacing endogenous succinyl-CoA dependent enzymes, we obtain an optimized TCA cycle-deficient E. coli strain. As a proof of concept, the strain is engineered for high-yield production of four separate products. This work enhances our understanding of the role of the TCA cycle in E. coli metabolism and demonstrates the advantages of using TCA cycle-deficient E. coli strain for biotechnological applications.
Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes
Authors: Zhou Xinrui , Seow Wan Yi , Ha Norbert , Cheng Teh How , Jiang Lingfan , Boonruangkan Jeeranan , Goh Jolene Jie Lin , Prabhakar Shyam , Chou Nigel , Chen Kok Hao
Published: March 2024

High-dimensional, spatially resolved analysis of intact tissue samples promises to transform biomedical research and diagnostics, but existing spatial omics technologies are costly and labor-intensive. We present Fluorescence In Situ Hybridization of Cellular HeterogeneIty and gene expression Programs (FISHnCHIPs) for highly sensitive in situ profiling of cell types and gene expression programs. FISHnCHIPs achieves this by simultaneously imaging ~2-35 co-expressed genes (clustered into modules) that are spatially co-localized in tissues, resulting in similar spatial information as single-gene Fluorescence In Situ Hybridization (FISH), but with ~2-20-fold higher sensitivity. Using FISHnCHIPs, we image up to 53 modules from the mouse kidney and mouse brain, and demonstrate high-speed, large field-of-view profiling of a whole tissue section. FISHnCHIPs also reveals spatially restricted localizations of cancer-associated fibroblasts in a human colorectal cancer biopsy. Overall, FISHnCHIPs enables fast, robust, and scalable cell typing of tissues with normal physiology or undergoing pathogenesis.
Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors
Authors: Chang Jiang , Wu Shurong , You Ting , Wang Jianfeng , Sun Bingjing , Xu Bojun , Xu Xiaochun , Zhang Yaping , Wu Shuang
Published: March 2024

About one third of vascular plants develop glandular trichomes, which produce defensive compounds that repel herbivores and act as a natural biofactory for important pharmaceuticals such as artemisinin and cannabinoids. However, only a few regulators of glandular structures have been characterized so far. Here we have identified two closely-related MYB-like genes that redundantly inhibit the formation of glandular cells in tomatoes, and they are named as GLAND CELL REPRESSOR (GCR) 1 and 2. The GCR genes highly express in the apical cells of tomato trichomes, with expression gradually diminishing as the cells transition into glands. The spatiotemporal expression of GCR genes is coordinated by a two-step inhibition process mediated by SlTOE1B and GCRs. Furthermore, we demonstrate that the GCR genes act by suppressing Leafless (LFS), a gene that promotes gland formation. Intriguingly, homologous GCR genes from tobacco and petunia also inhibit gland formation, suggesting that the GCR-mediated repression mechanism likely represents a conserved regulatory pathway for glands across different plant species.
Exploring functional dysconnectivity in schizophrenia: alterations in eigenvector centrality mapping and insights into related genes from transcriptional profiles
Authors: Ji Yuan , Cai Mengjing , Zhou Yujing , Ma Juanwei , Zhang Yijing , Zhang Zhihui , Zhao Jiaxuan , Wang Ying , Jiang Yurong , Zhai Ying , Xu Jinglei , Lei Minghuan , Xu Qiang , Liu Huaigui , Liu Feng
Published: March 2024

Schizophrenia is a mental health disorder characterized by functional dysconnectivity. Eigenvector centrality mapping (ECM) has been employed to investigate alterations in functional connectivity in schizophrenia, yet the results lack consistency, and the genetic mechanisms underlying these changes remain unclear. In this study, whole-brain voxel-wise ECM analyses were conducted on resting-state functional magnetic resonance imaging data. A cohort of 91 patients with schizophrenia and 91 matched healthy controls were included during the discovery stage. Additionally, in the replication stage, 153 individuals with schizophrenia and 182 healthy individuals participated. Subsequently, a comprehensive analysis was performed using an independent transcriptional database derived from six postmortem healthy adult brains to explore potential genetic factors influencing the observed functional dysconnectivity, and to investigate the roles of identified genes in neural processes and pathways. The results revealed significant and reliable alterations in the ECM across multiple brain regions in schizophrenia. Specifically, there was a significant decrease in ECM in the bilateral superior and middle temporal gyrus, and an increase in the bilateral thalamus in both the discovery and replication stages. Furthermore, transcriptional analysis revealed 420 genes whose expression patterns were related to changes in ECM, and these genes were enriched mainly in biological processes associated with synaptic signaling and transmission. Together, this study enhances our knowledge of the neural processes and pathways involved in schizophrenia, shedding light on the genetic factors that may be linked to functional dysconnectivity in this disorder.
Exploring research trends and priorities of genus Melia
Authors: S Suresh Ramanan , Arunachalam Ayyanadar , Sahoo Uttam Kumar , Upadhyaya Kalidas
Published: March 2024

The genus Melia is known for its secondary metabolites and recently, this genus is being explored for its timber. There are vast differences among its species. For instance, Melia azedarach is reported to be invasive and while another species, M. dubia, has diverse utility with complex germination and regeneration characteristics. Researchers globally have been working on various aspects of this genus; In this study, using topic modelling and science mapping approach, we attempted to understand research facets on this genus. The literature corpus of the Web of Science database was explored using a single keyword—“Melia” which yielded 1523 publications (1946–2022) and after scrutiny metadata of 1263 publications were used in the study. Although nine individual species were cited in the publications, only three species are accepted viz., M. dubia, M. azedarach, and M. volkensii. This implies taxonomic uncertainty, with potential confusion in assigning scientific findings to particular species. Thus, a taxonomic relook on this genus is warranted for a better assessment of the economic utility in many countries. More importantly, our results indicate that the research interests have recently shifted from the secondary metabolite constituents towards growth, biomass, wood properties, germination, plantation, and green synthesis. The shift in research focus toward wood properties of Melia sp. can impact the wood demand–supply at a global scale owing to its fast growth and the possibility of cultivation over a wider geographical range.
Design, control, aerodynamic performances, and structural integrity investigations of compact ducted drone with co-axial propeller for high altitude surveillance
Authors: Jayakumar Shyam Sundar , Subramaniam Indira Prasanth , Stanislaus Arputharaj Beena , Solaiappan Senthil Kumar , Rajendran Parvathy , Lee It Ee , Madasamy Senthil Kumar , Gnanasekaran Raj Kumar , Karuppasamy Arunkumar , Raja Vijayanandh
Published: March 2024

Compact multi-rotor unmanned aerial vehicles (UAVs) can be operated in many challenging environmental conditions. In case the UAV requires certain considerations in designing like lightweight, efficient propulsion system and others depending upon the application, the hybrid UAV comes into play when the usual UAV types cannot be sufficient to meet the requirements. The propulsion system for the UAV was selected to be coaxial rotors because it has a high thrust-to-weight ratio and to increase the efficiency of the propulsion system, a unique propeller was proposed to achieve higher thrust. The proposed propeller was uniquely designed by analyzing various airfoil sections under different Reynolds’s number using X-Foil tool to obtain the optimum airfoil section for the propellers. Since the design with duct increases efficiency, the Hybrid UAV presented in this paper has the modified novel convergent–divergent (C–D)-based duct which is a simplified model of a conventional C–D duct. The yawing and rolling maneuverings of the UAV could be achieved by the thrust vectoring method so that the design is simpler from a structural and mechanical perspective. The use of UAVs has risen in recent years, especially compact UAVs, which can be applied for applications like surveillance, detection and inspection, and monitoring in a narrow region of space. The design of the UAV is modeled in CATIA, and its further performance enactment factors are picked from advanced computational simulations relayed bottom-up approach. The predominant computational fluid dynamics (CFD) and fluid structure interaction (FSI) investigations are imposed and optimized through Computational Analyses using Ansys Workbench 17.2, which includes analysis of structural behaviour of various alloys, CFRP and GFRP based composite materials. From the structural analysis Titanium alloy came out to be the best performing materials among the others by having lower total deformation and other parameters such as normal and equivalent stress. The dynamics control response is obtained using MATLAB Simulink. The validations are carried out on the propeller using a thrust stand for CFD and on the duct through a high-jet facility for structural outcomes to meet the expected outcome.
Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women
Authors: Mizuno Satoshi , Wagata Maiko , Nagaie Satoshi , Ishikuro Mami , Obara Taku , Tamiya Gen , Kuriyama Shinichi , Tanaka Hiroshi , Yaegashi Nobuo , Yamamoto Masayuki , Sugawara Junichi , Ogishima Soichi
Published: March 2024

Recently, many phenotyping algorithms for high-throughput cohort identification have been developed. Prospective genome cohort studies are critical resources for precision medicine, but there are many hurdles in the precise cohort identification. Consequently, it is important to develop phenotyping algorithms for cohort data collection. Hypertensive disorders of pregnancy (HDP) is a leading cause of maternal morbidity and mortality. In this study, we developed, applied, and validated rule-based phenotyping algorithms of HDP. Two phenotyping algorithms, algorithms 1 and 2, were developed according to American and Japanese guidelines, and applied into 22,452 pregnant women in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank project. To precise cohort identification, we analyzed both structured data (e.g., laboratory and physiological tests) and unstructured clinical notes. The identified subtypes of HDP were validated against reference standards. Algorithms 1 and 2 identified 7.93% and 8.08% of the subjects as having HDP, respectively, along with their HDP subtypes. Our algorithms were high performing with high positive predictive values (0.96 and 0.90 for algorithms 1 and 2, respectively). Overcoming the hurdle of precise cohort identification from large-scale cohort data collection, we achieved both developed and implemented phenotyping algorithms, and precisely identified HDP patients and their subtypes from large-scale cohort data collection.
Polygenic risk score-based prediction of breast cancer risk in Taiwanese women with dense breast using a retrospective cohort study
Authors: Hung Chih-Chiang , Moi Sin-Hua , Huang Hsin-I , Hsiao Tzu-Hung , Huang Chi-Cheng
Published: March 2024

Mammographic screening has contributed to a significant reduction in breast cancer mortality. Several studies have highlighted the correlation between breast density, as detected through mammography, and a higher likelihood of developing breast cancer. A polygenic risk score (PRS) is a numerical score that is calculated based on an individual's genetic information. This study aims to explore the potential roles of PRS as candidate markers for breast cancer development and investigate the genetic profiles associated with clinical characteristics in Asian females with dense breasts. This is a retrospective cohort study integrated breast cancer screening, population genotyping, and cancer registry database. The PRSs of the study cohort were estimated using genotyping data of 77 single nucleotide polymorphisms based on the PGS000001 Catalog. A subgroup analysis was conducted for females without breast symptoms. Breast cancer patients constituted a higher proportion of individuals in PRS Q4 (37.8% vs. 24.8% in controls). Among dense breast patients with no symptoms, the high PRS group (Q4) consistently showed a significantly elevated breast cancer risk compared to the low PRS group (Q1–Q3) in both univariate (OR = 2.25, 95% CI 1.43–3.50, P < 0.001) and multivariate analyses (OR: 2.23; 95% CI 1.41–3.48, P < 0.001). The study was extended to predict breast cancer risk using common low-penetrance risk variants in a PRS model, which could be integrated into personalized screening strategies for Taiwanese females with dense breasts without prominent symptoms.
Reliable relay assisted communications for IoT based fall detection
Authors: Alharbi Khulud K. , Alvi Sajid H. , Ali Bakhtiar , Mirza Jawad , Javed Muhammad Awais , Alharbi Hatem A.
Published: March 2024

Robust wireless communication using relaying system and Non-Orthogonal Multiple Access (NOMA) will be extensively used for future IoT applications. In this paper, we consider a fall detection IoT application in which elderly patients are equipped with wearable motion sensors. Patient motion data is sent to fog data servers via a NOMA-based relaying system, thereby improving the communication reliability. We analyze the average signal-to-interference-plus-noise (SINR) performance of the NOMA-based relaying system, where the source node transmits two different symbols to the relay and destination node by employing superposition coding over Rayleigh fading channels. In the amplify-and-forward (AF) based relaying, the relay re-transmits the received signal after amplification, whereas, in the decode-and-forward (DF) based relaying, the relay only re-transmits the symbol having lower NOMA power coefficient. We derive closed-form average SINR expressions for AF and DF relaying systems using NOMA. The average SINR expressions for AF and DF relaying systems are derived in terms of computationally efficient functions, namely Tricomi confluent hypergeometric and Meijer’s G functions. Through simulations, it is shown that the average SINR values computed using the derived analytical expressions are in excellent agreement with the simulation-based average SINR results.
Analysis of the potential application of a residential composite energy storage system based on a double-layer optimization model
Authors: Zhao Xueyuan , Ying Xiaoyu , Gao Weijun , Qian Fanyue , Tan Yang , Xie Jing
Published: March 2024

Along with the further integration of demand management and renewable energy technology, making optimal use of energy storage devices and coordinating operation with other devices are key. The present study takes into account the current situation of power storage equipment. Based on one year of measured data, four cases are designed for a composite energy storage system (ESS). In this paper, a two-tiered optimization model is proposed and is used to optimizing the capacity of power storage devices and the yearly production of the system. Furthermore, this paper performs a comparative analysis of the performance of the four cases from the energy, environmental and economic perspectives. It is concluded that this kind of energy storage equipment can enhance the economics and environment of residential energy systems. The thermal energy storage system (TESS) has the shortest payback period (7.84 years), and the CO2 emissions are the lowest. Coupled with future price volatility and the carbon tax, the electrothermal hybrid energy storage system (HESS) has good development potential. However, the current investment cost is very high, and it will not be possible to recover this cost in 10 years. Finally, it is recommended that the cost of equipment be reduced in combination with subsidies and incentives for further promotion. The research results not only fill a gap in the study area, but also provide some suggestions for further development of industry and research on user-side energy storage.
Both local stability and dispersal contribute to metacommunity sensitivity to asynchronous habitat availability
Authors: Moisset de Espanés Pablo , Ramos-Jiliberto Rodrigo
Published: March 2024

The stability of isolated communities depends on the complexity of their foodwebs. However, it remains unclear how local stability interacts with dispersal in multitrophic metacommunities to shape biodiversity patterns. This lack of understanding is deeper in the more realistic frame of landscapes that exhibit non-trivial and time-varying structures. Therefore, in this study, we aim to evaluate the influence of local stabilizing factors versus dispersal in determining the sensitivity of metacommunity biodiversity to increasing asynchrony of site availability. Additionally, we assess the role of foodweb complexity and landscape structure as modulating factors. To accomplish our goals we developed a model based on random matrices for local communities, which are linked by stochastic dispersal over explicit dynamic landscapes. We ran numerical simulations and computed the effect sizes of foodweb temperature, self-limitation, dispersal ability, and all pairwise combinations, on the sensitivity of biodiversity to landscape asynchrony. In our experiments we explored gradients of species richness, foodweb connectance, number of sites, and landscape modularity. Our results showed that asynchrony among site availability periods reduced $$\alpha$$
α
-diversity and increased $$\beta$$
β
-diversity. Asynchrony increased $$\gamma$$
γ
-diversity at high dispersal rates. Both local and regional stabilizing factors determined the sensitivity of metacommunities to landscape asynchrony. Local factors were more influential in landscapes with fewer sites and lower modularity, as well as in metacommunities composed of complex foodwebs. This research offers insights into the dynamics of metacommunities in dynamic landscapes, providing valuable knowledge about the interplay between local and regional factors in shaping ecological stability and species persistence.
Synthesis of novel organophosphorus compounds via reaction of substituted 2-oxoindoline-3-ylidene with acetylenic diesters and triphenylphosphine or triphenyl phosphite
Authors: Najafi Mahsa , Marandi Ghasem
Published: March 2024

An efficient reaction between triphenylphosphine or triphenyl phosphite and 2-oxoindoline-3-ylidene derivatives in the presence of acetylenic esters leads to functionalized 2-oxoindoline-3-ylidene containing phosphorus ylieds or phosphonate esters. All compounds obtained in these reactions are stable and have good yields.
Bearded capuchin monkeys as a model for Alzheimer’s disease
Authors: Diehl Rodriguez Roberta , Tavares Maria Clotilde H. , Brucki Sonia Maria Dozzi , Takada Leonel Tadao , Otaduy Maria Concepción Garcia , da Graça Morais Martin Maria , Kimie Suemoto Claudia , Grinberg Lea T. , Leite Claudia Costa , Tomaz Carlos , Nitrini Ricardo
Published: March 2024

The absence of a natural animal model is one of the main challenges in Alzheimer’s disease research. Despite the challenges of using nonhuman primates in studies, these animals can bridge mouse models and humans, as nonhuman primates are phylogenetically closer to humans and can spontaneously develop AD-type pathology. The capuchin monkey, a New World primate, has recently attracted attention due to its skill in creating and using instruments. We analyzed one capuchin brain using structural 7 T MRI and performed a neuropathological evaluation of three animals. Alzheimer-type pathology was found in the two of the capuchins. Widespread β-amyloid pathology was observed, mainly in focal deposits with variable morphology and a high density of mature plaques. Notably, plaque-associated dystrophic neurites associated with disruption of axonal transport and early cytoskeletal alteration were frequently found. Unlike in other species of New World monkeys, cerebral arterial angiopathy was not the predominant form of β-amyloid pathology. Additionally, abnormal aggregates of hyperphosphorylated tau, resembling neurofibrillary pathology, were observed in the temporal and frontal cortex. Astrocyte hypertrophy surrounding plaques was found, suggesting a neuroinflammatory response. These findings indicate that aged capuchin monkeys can spontaneously develop Alzheimer-type pathology, indicating that they may be an advantageous animal model for research in Alzheimer’s disease.
Exploiting long read sequencing to detect azole fungicide resistance mutations in Pyrenophora teres using unique molecular identifiers
Authors: Zulak Katherine G. , Farfan-Caceres Lina , Knight Noel L. , Lopez-Ruiz Francisco J.
Published: March 2024

Resistance to fungicides is a global challenge as target proteins under selection can evolve rapidly, reducing fungicide efficacy. To manage resistance, detection technologies must be fast and flexible enough to cope with a rapidly increasing number of mutations. The most important agricultural fungicides are azoles that target the ergosterol biosynthetic enzyme sterol 14α-demethylase (CYP51). Mutations associated with azole resistance in the Cyp51 promoter and coding sequence can co-occur in the same allele at different positions and codons, increasing the complexity of resistance detection. Resistance mutations arise rapidly and cannot be detected using traditional amplification-based methods if they are not known. To capture the complexity of azole resistance in two net blotch pathogens of barley we used the Oxford Nanopore MinION to sequence the promoter and coding sequence of Cyp51A. This approach detected all currently known mutations from biologically complex samples increasing the simplicity of resistance detection as multiple alleles can be profiled in a single assay. With the mobility and decreasing cost of long read sequencing, we demonstrate this approach is broadly applicable for characterizing resistance within known agrochemical target sites.
Decadal demographic shifts and size-dependent disturbance responses of corals in a subtropical warming hotspot
Authors: Sommer Brigitte , Hodge Jessica M. , Lachs Liam , Cant James , Pandolfi John M. , Beger Maria
Published: March 2024

Long-term demographic studies at biogeographic transition zones can elucidate how body size mediates disturbance responses. Focusing on subtropical reefs in eastern Australia, we examine trends in the size-structure of corals with contrasting life-histories and zoogeographies surrounding the 2016 coral bleaching event (2010–2019) to determine their resilience and recovery capacity. We document demographic shifts, with disproportionate declines in the number of small corals and long-term persistence of larger corals. The incidence of bleaching (Pocillopora, Turbinaria) and partial mortality (Acropora, Pocillopora) increased with coral size, and bleached corals had greater risk of partial mortality. While endemic Pocillopora experienced marked declines, decadal stability of Turbinaria despite bleaching, coupled with abundance increase and bleaching resistance in Acropora indicate remarkable resilience of these taxa in the subtropics. Declines in the number of small corals and variable associations with environmental drivers indicate bottlenecks to recovery mediated by inhibitory effects of thermal extremes for Pocillopora (heat stress) and Acropora (heat and cold stress), and stimulatory effects of chlorophyll-a for Turbinaria. Although our study reveals signs of resilience, it foreshadows the vulnerability of subtropical corals to changing disturbance regimes that include marine heatwaves. Disparity in population dynamics suggest that subtropical reefs are ecologically distinct from tropical coral reefs.
Microscopic characteristics and sources of atmospheric dustfall in open-pit mining coal resource-based city in the arid desert area of Northwest China
Authors: Deng Yayuan , Wu Hongxuan , Zhao Tingning , Shi Changqing , Zhang Yan , Li Feng
Published: March 2024

Atmospheric dustfall is solid air pollutant, has a major impact on the environment and human health. The objective of this study was to investigate the microscopic characteristics and sources of atmospheric dustfall in open-pit mining coal resource-based city in the arid desert area of Northwest China. The characteristics of size and shape factors, variation of shape factors with size distribution, types of individual particles, and sources of atmospheric dustfall, which were collected in the open-pit mining area and surrounding areas, were analyzed by X-ray diffraction (XRD) and scanning electron microscopy coupled with an energy dispersive spectrometer (SEM–EDS) combined with graphical method and shape factors. The results showed that the atmospheric dustfall in all functional areas was dominated by coarse-grained particles. The shape of the atmospheric dustfall deviated from spherical shape, and with decreasing particle size, the difference in shape factors increased in each functional area. The EDS and XRD analyses indicated the presence of 13 types of particles. The sources were mainly local and included soil dust from each functional area; industrial dust, construction dust, biogenic impurities, fossil fuel combustion, wear products of motor vehicle parts, motor vehicle exhaust emissions, and emission and excreta from biological activities in each functional area except the desert area; emissions from a steel plant in the industrial area; coal-associated ore, coal dust, coal gangue emissions, and emissions from the spontaneous combustion of coal gangue in the open-pit mining area; secondary chemical crystallization products in the industrial area and the open-pit mining area; dust generated by vehicles abrading the surface of the off-mine coal road and in the open-pit mining area.