bluuebunny/crossref_metadata_2025 huggingface dataset:
Fault Identification for the Purposes of Evaluating the Risk of Induced Seismicity: A Novel Application of the Flowback DFIT
Authors: Zeinabady D. , Clarkson C. R. , Razzaghi S. , Haqparast S. , Benson A. L. , Azad M.
Published: January 2023

The existence of faults, pre-existing hydraulic fractures, and depleted areas can negatively impact the development of unconventional reservoirs using multifractured horizontal wells (MFHWs). For example, the triggering of fault slippage through hydraulic fracturing can create the environmental hazard known as induced seismicity (earthquakes caused by hydraulic fracturing). A premium has therefore been placed on the development of technologies that can be used to identify the locations of fault systems (particularly if they are subseismic) as well as pre-existing hydraulic fractures and depleted areas. The objective of this study is to develop a diagnostic tool to identify these conditions using DFIT-FBA, a modified diagnostic fracture injection test (DFIT) with flowback analysis (FBA). The time and cost efficiencies of the DFIT-FBA method in reservoir characterization provides an opportunity to conduct multiple field tests at a single point or along the lateral section of a horizontal well.

An analytical model that considers critical processes and mechanisms occurring during DFIT-FBA was first developed herein. The results of analytical modeling demonstrate that reservoir heterogeneities (i.e., faults) can be identified either by implementing multiple cycles of the DFIT-FBA method at a single point or by applying multiple DFIT-FBAs at different points along the lateral section of a horizontal well or at different wells. The analytical model is then verified using a fully coupled hydraulic fracture, reservoir, and wellbore simulator, and flowing pressure responses in the presence of a fault are illustrated. The practical application of the proposed method is demonstrated using DFIT-FBA field examples performed in a tight reservoir. Analysis of the field examples leads to the conclusion that a fault likely occurs near the toe of the horizontal lateral. This finding was confirmed by other field information and provides the opportunity to modify the main-stage hydraulic fracturing design to avoid induced seismicity events.
Rapid Simulation of Unconventional Reservoirs by Multidomain Multiresolution Modeling Based on the Diffusive Time of Flight
Authors: Chen Hongquan , Li Ao , Terada Kazuyuki , Datta-Gupta Akhil
Published: January 2023

The fast marching method (FMM)-based rapid flow simulation has been shown to accelerate simulation efficiency by orders of magnitude by transforming 3D simulation to equivalent 1D simulation using the concept of the “diffusive time of flight” (DTOF). However, the 1D transformation does not directly apply to multiwell problems. In this paper, we propose a novel DTOF-based multidomain multiresolution discretization scheme to accelerate multiwell simulation of unconventional reservoirs. Our method formulates multiwell simulation problems based on the DTOF which displays the pressure front propagation in unconventional reservoirs. The DTOF contours are used to partition the reservoir into local and shared domains. A local domain is where the flow is dominated by a single well, and the shared domain is where the fluid flow is influenced by multiple wells. The DTOF contours expand independently in local domains and interfere in the shared domain. After the partitioning, each domain is discretized using a multiresolution scheme whereby the original 3D fine mesh is preserved near the wells to account for detailed physics including gravity, and the rest of the domain is discretized into 1D mesh based on the DTOF contours to alleviate the simulation workload. The power and efficacy of our approach are demonstrated using synthetic and field-scale simulation models with different degrees of geologic and well-completion complexity. The simulation results, number of active cells, and computation time for the proposed discretization scheme are compared with the original high-fidelity 3D model for each case. The results show that the proposed method is suitable for multiwell simulation problems in unconventional reservoirs and can accelerate flow simulations by orders of magnitude with minimal loss of accuracy. The novelty of this work is the creation of DTOF-derived multiresolution discretization with local and shared domains to simplify and accelerate the calculation of subsurface flow problems, especially in unconventional reservoirs. Our workflow can be easily interfaced with commercial simulators, making it suitable for large-scale field applications.
A Critical Study on the Operation of the Police District Unit(Police Box): Focusing on securing the effectiveness of the Autonomous Police System
Authors:   Korean Association of Public Safety and Criminal Justice, Jung Se Jong
Published: January 2023

With the implementation of the revised Police Act, security affairs were converted into “national police affairs (public safety),” “criminal investigation,” and “autonomous police affairs”.
This study was planned under the awareness that the police are oblivious to the legislative purpose of the “Police Act” by unfairly operating a police district unit(police box).
In this paper, four issues were derived and the following comments were developed.
First, the local police spend most of their time on autonomous police affairs, except for the initial action on criminal investigations.
Second, if the head of the autonomous police department in charge of autonomous police affairs is excluded from the command line of the local police, there is a high concern that the authority to command and supervise the municipal and provincial police committees on autonomous police affairs will become nominal.
Third, the Police Act stipulates that the municipal and provincial police committees are in charge of the appointment and evaluation of public officials in charge of autonomous police affairs. However, by excluding local police officers who perform local police affairs from the category of “police officers in charge of autonomous police affairs” in Article 4 (1) of the Police Officials Appointment Order, the personnel authority of the municipal and provincial police committees is overshadowed.
Fourth, Article 28 (3) of the Police Act stipulates, “The head of the city and provincial police shall take charge of autonomous police affairs under the direction and supervision of the city and provincial police committees.” However, it has become very difficult for the municipal and provincial police committees to exercise their command and supervision rights for local police affairs.
DOPESLAM: A high-precision ROS-based semantic SLAM system
Authors: Roch Jesse , Najjaran Homayoun
Published: January 2023

Recent advancements in deep learning techniques have accelerated the growth of robotic vision systems. One way this technology can be applied is to use a mobile robot to automatically generate a 3D map and identify objects within it. This paper explores a solution to this problem by combining Deep Object Pose Estimation (DOPE) with Real-Time Appearance-Based Mapping (RTAB-Map) through means of loose-coupled parallel fusion. DOPE’s abilities are enhanced by leveraging its belief map system to filter uncertain key points which increases precision so only the best object labels end up on the map. Additionally, DOPE’s pipeline is modified to enable shape-based object recognition using depth maps so it can identify objects in complete darkness. Three experiments are performed to find the ideal training dataset, quantify the increased precision, and to evaluate the overall performance of the system. The results show the proposed solution outperforms existing methods in most intended scenarios such as in unilluminated scenes.
Discovery of a Vertebral Skeletal Stem Cell Driving Spinal Metastases
Authors: Greenblatt Matthew , Sun Jun , Hu Lingling , Bok Seoyeon , Yallowitz Alisha , Cung Michelle , McCormick Jason , Zheng Ling , Debnath Shawon , Niu Yuzhe , Tan Adrian , Lalani Sarfaraz , Morse Kyle , Shinn Daniel , Pajak Anthony , Li Zan , Li Na , Xu Ren , Iyer Sravisht
Published: January 2023

Vertebral bone is subject to a distinct set of disease processes from those of long bones, notably including a much higher rate of solid tumor metastases that cannot be explained by passive blood flow distribution alone. The basis for this distinct biology of vertebral bone has remained elusive. Here we identify a vertebral skeletal stem cell (vSSC), co-expressing the transcription factors ZIC1 and PAX1 together with additional cell surface markers, whose expression profile and function are markedly distinct from those of long bone skeletal stem cells (lbSSCs). vSSCs display formal evidence of stemness, including self-renewal, label retention and sitting at the apex of their differentiation hierarchy. Lineage tracing of vSSCs confirms that they make a persistent contribution to multiple mature cell lineages in the native vertebrae. vSSCs are physiologic mediators of spine mineralization, as genetic blockade of the ability of vSSCs to generate osteoblasts results in defects in the vertebral neural arch and body. Human counterparts of vSSCs can be identified in vertebral endplate specimens and display a conserved differentiation hierarchy and stemness. Multiple lines of evidence indicate that vSSCs contribute to the high rates of vertebral metastatic tropism observed clinically in breast cancer. Specifically, when an organoid system is used to place both vSSCs and lbSSCs in an identical anatomic context, vSSC-lineage cells are more efficient than lbSSC-lineage cells at recruiting metastases, a phenotype that is due in part to increased secretion of the novel metastatic trophic factor MFGE8. Similarly, genetically targeting loss-of-function to the vSSC lineage results in reduced metastasis rates in the native vertebral environment. Taken together, vSSCs are distinct from other skeletal stem cells and mediate the unique physiology and pathology of vertebrae, including contributing to the high rate of metastatic seeding of the vertebrae.
Propensity score-matched analysis comparing Hippocampus-Avoidance Whole-Brain Radiotherapy plus Simultaneous Integrated Boost with Hippocampus-Avoidance Whole-Brain Radiotherapy alone for multiple brain metastases-a retrospective study in multiple institutions
Authors: wang xiaoliang , Chen Jinping , Lei Zhanquan , Chen Haihong , Zhang Yufang , Liu Gang , Li Shaomin , Zheng Zhenhua , Wang Hui
Published: January 2023

Background: The optimal treatment for multiple brain metastases has been recently controversially discussed.This study was aimed to explore the feasibility of Hippocampus-Avoidance Whole-Brain Radiotherapy plus a simultaneous integrated boost(HA-WBRT+SIB) in the treatment of multiple brain metastases and assess tumor control in compared with Hippocampus-Avoidance Whole-Brain Radiotherapy(HA-WBRT) alone for brain metastases.
Methods: In this study, 63 patients with multiple brain metastases(≥4 metastases) had undergone HA-WBRT+SIB between January 2016 and December 2020 in the observation group：HA-WBRT (30Gy in 12 fractions, the maximum dose of the hippocampus≤14Gy) plus a simultaneous integrated boost(48Gy in 12 fractions) for brain metastases.Overall Survival (OS),Median survival,intracranial control (IC=control within the entire brain), intracranial progression-free survival(iPFS) and adverse events were compared with the control group(a HA-WBRT retrospective cohort) by propensity score matching analysis.
Results: After 1:1 propensity score matching,there were 56 patients in each group(the observation group,the control group). OS, media survival and iPFS were significantly longer in the observation group(18.4 vs 10.9 months,P＜0.001),(13.0 vs 8.0 months,P＜0.001),(13.9vs7.8 months,P＜0.001). In comparison of 1-year-IC rates, the observation group also demonstrated higher than the control group (51.8% vs 21.4%,P=0.002), respectively. Seven hippocampal metastases were found in the control group (4/56,7.1%) and observation group(3/56,5.4%) after HA-WBRT. The death rate of intracranial progression were 23.2% in the observation group and 37.5% in the control group.All adverse events were not significant difference between the two groups(P＞0.05).
Conclusions: HA-WBRT+SIB resulted in better OS,media survival,IC,iPFS, an acceptable risk of radiation response,and a potential way of declining neurocognitive adverse events,which may be a better treatment for patients with multiple brain metastases.
Assessment of Knowledge, Attitude and Practice of Residents towards Civil Registration and Vital Statistics in Gurage Zone, Ethiopia
Authors: Chernet Ayele Gebeyehu , Trueha Kassahun , Muanenda Sebsib , Cherie Kebadu Tadesse , Lentiro Kifle
Published: January 2023

Background: Even if the Government of Ethiopia has given great emphasis to strengthen CRVS system throughout the country, the system is still in its infancy stage. Therefore, this research aimed to examine knowledge, attitude and practice of people towards CRVS in Gurage Zone, Ethiopia.
Methods: About 439 household from three districts and two cities administrative were selected using a multi-stage random sampling technique. Well-structured questionnaire on Knowledge, attitude and practice was prepared and information was collected and analyzed from the household head from December 15-20, 2020.
Result: The result revealed that most of the residents have enough knowledge and good attitude about CRVS. But only 22.6% up to 39% of them know the official registration time and the practice of vital event registration was found to be very low.
Conclusion: The result showed that the residents have good knowledge and attitude towards CRVS while the practice is very low. Hence, improving the practice of registering vital events by eliminating obstacles is expected from the local and national administrative.
Persistent HPV infection after conization of cervical intraepithelial neoplasia—— a systematic review and meta-analysis
Authors: Zhang Yueyang , Ni Zhiwen , Wei Ting , Liu Qingsong
Published: January 2023

Objective
To systematically evaluate several factors of human papillomavirus (HPV) persistent infection following conization in patients with cervical intraepithelial neoplasia (CIN).
Methods
PubMed, EMBASE and Cochrane library were retrieved from January 1, 1998 to September 10, 2021. Random-effects models for meta-analyses was used and pooled relative risks with 95% confidence intervals was reported. Literature screening, data extraction and assessment of the risk of bias in the included studies were conducted independently by two researchers. Data-analysis was performed with Stata software, version 12.0.
Results
A total of 28 studies were enrolled finally in this study. Meta-analysis revealed that surgical margin and residual disease were correlated positively with the persistent HPV infection after conization. Compared with patients infected with other types of HPV, CIN patients with HPV 16 have higher persistent infection rate (OR = 1.967, 95% CI (1.232–3.140), P < 0.05).
Conclusions
CIN patients with postmenopausal, surgical margin and residual lesions positive, and HPV 16 are prone to persistent HPV infection after conization.
The outcomes of transcatheter adrenal ablation in patients with primary aldosteronism：a systematic review and meta-analysis
Authors: Yang Shunfan , Wang Guoliang , Li Nanfang , Zhu Qing
Published: January 2023

Background: Transcatheter adrenal ablation as an alternative treatment for primary aldosteronism(PA) patients is still controversial and the outcomes varies widely in existing studies. The aim of this meta-analysis is to evaluate the result of adrenal ablation and estimate effectiveness and safety of this therapy method.
Methods: A comprehensive search was performed across Pubmed, Embase and Cochrane Library databases for studies published up to October 2022. The outcomes analyzed were the combined clinical success rate, biochemical success rate and complication rate, which was employed with a random-effects model.
Results: Five studies comprising 234 PA patients were included in the study. The combined clinical success rate was 74% (95% CI: 69%-79%) and the bichemical success rate was 74%(95%CI: 53%-95%). Subgroup analysis showed that the combined clinical success rate from Unilateral PA (72%, 95%CI: 46%-98%) was similar to the rate from Unilateral+bilateral(73%, 95%CI :52.0%-94.0%) and the clinical success rate of PASO subgroup(78%, 95%CI: 66.0%-89.0%) was higher than the rate of other criteria(51%, 95%CI: 40.0%-63.0%). The combined complication rate of mild fever was 23% (95% CI: 12%- 33%), back pain was 84% (95% CI: 77%- 91%) and pleural effusion was 9% (95%CI: 0% -18%). All complications disappeared within one week after the procedure. There were no late complications or ablation-related deaths.
Conclusions: The transcatheter adrenal ablation for PA patients is safe and has a relatively high clinical success rate. Currently, this approach is suitable for PA patients unwilling to accept surgery and long-term mineralocorticoid receptor antagonists(MRAs) treatment.
Systematic Review Registration: INPLASY, identifier 2022110076
Analysis of Anterior Permanent Dentition in Chinese population via Cone-beam Computed Tomography
Authors: CHEN YU , Lu Bingtai , Dai Yu , You Yuehua , Wu Bin , Yan Zhengbin
Published: January 2023

Purpose
Investigation of roots and canals is crucial in clinical assessment and treatment. Morphologies such as root length, cemento-enamel junction curvature (CEJ-C), root furcation and canal variations are important factors yet remain to be discussed in depth.
Methods
In this retrospective study, we look into 4309 anterior teeth from 401 patients via cone-beam computed tomography (CBCT) in Chinese population, attempting to summarize the morphological characteristics of maxillary and mandibular anterior teeth.
Results
Maxillary and mandibular canines are observed with elevated root length compared with corresponding incisors (p < .0001), while those of mandibular central and lateral incisor varied with significant difference (p < .0001). The CEJ-C reveals significant increasement around incisors than canines in maxilla (p < .0001). Root furcation is detected in mandibular canines and lateral incisors. Moreover, all types of Vertucci’s classification are noticed with two other new types.
Conclusions
The current findings help to optimize the root morphological understanding of Chinese population especially in endodontics. Moreover, CEJ-C facilitates clinical aesthetic interpretation and treatment in implantology and prosthodontic. However, further study should be carried out to investigate morphologies of posterior dentition.
Age-stratified association between plasma adiponectin levels and morality in septic patients
Authors: Wang Hui , Ma Ming , Gao Yan-xiang , Wu Yi-na , Zhai Shan-shan , Li Chen , Duan Jun
Published: January 2023

Background:Plasma adiponectin (APN) levels are might be affected by age. The present study aimed to study the association between plasm APN levels and age, and the effects of APN levels on mortality in different age-stratified septic patients.Methods:The retrospective study that was performed with 173 patients with sepsis and 57 controls. Physical and demographic characteristics were recorded, blood samples were collected to measure plasma adiponectin levels. Using these data, we determined the association between plasma adiponectin levels and age, and the effect of plasma adiponectin levels on mortality in different age-stratified septic patients.Results:Three age group were defined: middle-age patients range of <60years, the old group of 60-80 years, and the elderly group of ≥80years. Plasma adiponectin levels increased with increasing age both in control group and sepsis group. Mortality increased with age: 12.3% in middle-aged patients, 24.6% in old patients, and 36.2% in elderly patients (P<0.001). In middle-age patients and old patients, according to the receiver operating characteristic curve, plasma APN levels had the comparable value in prediction of 28-day mortality. And adiponectin levels were an independent predictive factor for 28-day mortality for patients <80 years. However, in elderly patients, the adiponectin levels showed no significant association with 28-day mortality.Conclusions:A significant positive association between plasma APN levels and age in septic patients were found. Low circulating levels of APN were associated with 28-day mortality in septic patients aged <80years. The association between APN and mortality in sepsis patients aged >80years were not significantly found.
Coral-reefs off North and West Africa – Environmental settings
Authors: Buhl-Mortensen Lene , Houssa Rachida , Bengue B.M. , Nyadjro E , Cervantes D , Idrissi M , Mahu E , Dia AS , Olsen M , Mas C , Chierici M
Published: January 2023

As part of the EAF Nansen Program, three cold-water coral sites have been studied along the West African coast: in Mauritania-Morocco and Ghana/Côte d'Ivoire. The aim was to investigate their health status in contrasting environment to obtain knowledge on the physiological ranges and adaptive capacity to multiple stressors. The used data concerns the landscape, depth, water masses, temperature, dissolved oxygen concentration (DO), carbonate chemistry (pH, aragonite saturation WAr), macronutrients and particles (visual). The results are compared to the health status of other Lophelia pertusa reefs in such contrasting environments. The results show that large healthy reefs of L. pertusa reside off Ghana and Mauritania in the oxygen minimum zone (OMZ) with DO concentrations between 1.1 and 1.6 ml L− 1. They are located in corrosive waters with the lowest pH and WAr and high nutrient levels. The reefs off Morocco reside in waters similar to the Norwegian reefs in well oxygenated waters with oversaturated WAr but was showed to be less healthy (dead) compared to the reefs in the other two sites that resided in the OMZ. This study demonstrates that L. pertusa thrives in OMZ and corrosive aragonite waters, suggesting local adaptation to these conditions and supporting recommendations to continue research work on the same species in contrasting environments for potential effects of climate change.
Sexual Orientation and Study Cycle: Income Differences in Brazil
Authors: Mantovani Gabriela Gomes , Staduto Jefferson Andronio Ramundo
Published: January 2023

This article aims to measure and analyze income disparities and discrimination between homosexuals and heterosexuals in different study cycles (low, medium, and high education) in Brazil. Recentered influence function (RIF) regressions and income decomposition (RIF decomposition) were performed using microdata from the Continuous National Household Sample Survey from two periods (2013 to 2015 and 2016 to 2019). The results show income disparities between homosexuals and heterosexuals. Income differences are different by gender and between both selected periods, although they are greater for highly skilled workers and women. Income decompositions showed that the explained effect was largely responsible for the difference in income between homosexuals and heterosexuals. The counterfactual effects – positive and negative – on the income of homosexuals generated by this effect were higher for men although a pattern of behavior was not found by study cycle or between periods.
JEL codes: J12; J16; J31
Ca & Sbo : A Novel Optimized Placement Algorithms for an Efficient Vlsi Design
Authors: R Pavithra Guru
Published: January 2023

Designing a simplest architecture involves appropriate placement, which is often, regarded as a critical concerns of physical design engineers. Placement and routing of chips in automated manner is been research since decades and provides better predictive performance than manual procedures. However, most of the automated models operating under meta-heuristic optimization fails in obtaining optimal solution due to premature convergence and non-optimal placement of solutions. In this paper, we develop a novel meta-heuristic optimization method namely Cellular Automata (CA) and Satin Bowerbird Optimization (SBO) that combines Primal-dual lagrangian technique (SimPL) and Complex Primal dual lagrangian (ComPL) for attaining optimal placement and routing of chips. The process of CA and SBO optimization approach operates on obtaining optimized placement solutions from the SimPL and ComPL solutions. The combination of CA-SimPL, SBO-SimPL, CA-ComPL and SBO-ComPL is implemented on electronic design automation (EDA) tools with python simulator for pre-training and fine-tuning the optimization model. The simulation is conducted on a high-end computing system to test the computational time speed up ratio on different threads and half-perimeter wire length (HWPL). The results of simulation shows that the proposed models obtain increased performance with reduced computational time than other methods.
The First case of Pseudomonas oleovorans Sepsis in China: a case report
Authors: Liu Junbao , Wang Xingang , Hao Duo , Xie Peitao , Wu Bo , Tian Yixuan , Su Changhai
Published: January 2023

Background

Pseudomonas oleovorans (P. oleovorans) is an environmental isolate and rarely implicated in human infections. The bacterium has been isolated only in one reported case of blood infections. This case report describes the isolation of a rare Pseudomonas bacterium in a patient presenting with sepsis.

Case presentation

A 72-year-old woman was presented to a hospital in the Ordos of China, with a 2-day history of fever, chills, abdominal pain and nausea. P. oleovorans was identified in the patient’s blood culture using the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). The patient discharged on piperacillin-tazobactam therapy 3 weeks after admission.

Conclusions

These findings suggest that less common species of Pseudomonas need to be identified accurately. P. oleovorans is a known environmental contaminant and must also be considered as a potential pathogen.
Mnemonic-trained brain tuning to a regular odd-even pattern subserves digit memory in children
Authors: Pan Yafeng , Hao Ning , Liu Ning , Zhao Yijie , Cheng Xiaojun , Ku Yixuan , Hu Yi
Published: January 2023

It is said that our species use mnemonics – that “magic of memorization” – to engrave an enormous amount of information in the brain. Yet, it is unclear how mnemonics affect memory and what the neural underpinnings are? In this electroencephalography study, we examined the hypotheses whether mnemonic training improved processing-efficiency and/or altered encoding-pattern to support memory enhancement. By 22-day training of a digit-image mnemonic (a custom memory technique used by world-class mnemonists), a group of children showed increased short-term memory after training, but with limited gain generalization. This training resulted in regular odd-even neural patterns (i.e., enhanced P200 and theta power during the encoding of digits at even- versus odd- positions in a sequence). Critically, the P200 and theta power effects predicted the training-induced memory improvement. These findings highlight the plasticity of the mnemonic system in the developmental brain, and provide evidence of how mnemonics alter encoding pattern, as reflected in functional brain organization, to support memory enhancement.
UXT-V1 contributes to the malignant phenotypes of colorectal cancer via GSK3β by activating Wnt/β-catenin pathway
Authors: Chen Guanjun , Chen Huili , Xiao Qiaoqiao , Zhou Xinrui , Wang Fei , Chen Shuliang , Yu Xiaolan , Luo Fan , Li Li
Published: January 2023

Background: Colorectal cancer (CRC) is one of malignant tumors that seriously threatening human health. β-catenin is a central hub in Wnt pathway, aberrant activation of Wnt/β-catenin signaling pathway promotes the tumorigenesis/progression of CRC.
Methods and Results: Here we found a β-catenin interactor, UXT-V1, could modulate Wnt signaling. The expression of UXT-V1 mRNA was increased in CRC tissues. Overexpression of UXT-V1 increased the canonical Wnt signaling, as evidenced by Wnt reporter systems and the up-regulation of marker genes including Axin, CyclinD1 and c-Myc. While, knockdown of UXT-V1 impaired the expression of these genes and attenuated Wnt signaling. Mechanistically, overexpression of UXT-V1 could inhibit GSK3β mediated β-catenin phosphorylation and degradation. Knockout of UXT-V1 increased β-catenin phosphorylation, prevented CRC cell growth, and inhibited tumorigenesis in NOD-SCID mice.
Conclusions: Taken together, our findings revealed that UXT-V1 could control Wnt signaling through targeting GSK3β mediated β-catenin phosphorylation and degradation, providing a molecular basis for CRC treatment.
HELP – Heidelberg decision aid for lung cancer patients. A randomized controlled clinical trial
Authors: Deis Nicole , Unsöld Laura , Siegle Anja , Krisam Johannes , Thomas Michael , Villalobos Matthias
Published: January 2023

Background: Shared decision-making (SDM), which increases the patient's well-being, adherence, and the success of treatment, is becoming increasingly important in medicine and especially in oncology. To empower patients to participate more actively in consultations with their physicians, decision aids have been developed. In non-curative settings, such as the treatment of advanced lung cancer, decisions differ substantially from the curative setting, as uncertain gains in terms of survival outcomes and quality of life have to be weighed against severe side-effects of treatment regimens. There is still a lack of tools developed and implemented for such specific settings in cancer therapy that support shared decision-making. The aim of our study is to evaluate the effectiveness of the HELP decision aid.
Methods: The HELP-study is designed as a randomized, controlled, open monocenter trial with two parallel groups. The intervention consists of the use of the HELP decision aid brochure, accompanied by a decision-coaching session. The primary endpoint is clarity of personal attitude as operationalized by the Decisional Conflict Scale (DCS) after the decision-coaching. Randomization will be performed as stratified block randomization according to the characteristic of preferred decision-making at baseline with a 1:1 allocation.
The participants in the control group get usual care, i.e. the doctor-patient conversation takes place without preliminary coaching and deliberation about their preferences and goals.
Discussion: Developing decision aids (DA) for (lung) cancer patients with limited prognosis should empower patients to address these aspects and include information about “Best Supportive Care” as a treatment option. Using and implementing the decision aid HELP can not only give patients the possibility to include their personal wishes and values in the decision-making process, but also raise the awareness of shared decision-making itself among these patients and their physicians.
Trial registration: DRKS00028023 [registered on 8 February 2022]
Lipidomic signature of stroke recurrence after transient ischemic attack
Authors: Purroy Francisco , Ois A , Jove M. , Arque G , Sol J , Mauri-Capdevila G , Campello A. Rodriguez , Pamplona R , Portero M , Roquer J
Published: January 2023

Objective
To find new biomarkers of early stroke recurrence (SR) by using lipidomic strategies on patients who suffered a transient ischemic attack.
Methods
Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients. Recruited < 24 hours after the onset of symptoms.
Results
SR at 90 days follow-up was showed by 37 (8%) patients. In Cox proportional hazards models previous ischemic stroke (95%CI, 1.07–5.75), motor weakness (95%CI, 1.14–4.98), large-artery atherosclerosis (95%CI, 1.20–5.23) and female sex (95%CI, 1.31–5.46) were predictors of SR. Lipidomic profiling disclosed specific SR biomarkers: 7 lipid species differentially expressed between groups. Interestingly, 6 of these 7 lipid species belonged to the glycerolipid family and the other one is a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. Indeed, the detected lipid set express a condition of impaired response to energy supply and stress in SR patients compared to TIA non-SR patients. In this context, it is proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.
Conclusion
the lipidomic profiles of TIA subjects with non-SR and SR were different, with minor but significant changes. The observed changes in lipid patternssuggest pathophysiological mechanisms associated with the different formation of lipid droplets that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to early SR.
Blockchain and Mobile Client Privacy Protection in E-Commerce Consumer Shopping Tendency Identification Application
Authors: Liu Ruiqian , Wang Enjiang
Published: January 2023

In recent years, China's e-commerce has made great progress, and the growth trend of online shopping is obvious. Although China's online sales are far below half of the United States. One of the important reasons is the privacy risks of e-commerce and insufficient consumer trust, but it still hinders the development of e-commerce online shopping applications. According to the trust survey, interaction is an important condition for generating trust and an important element. However, in the existing e-commerce trust surveys, the impact of interaction is analyzed, but few surveys only have an impact on consumers' shopping tendency. Therefore, considering the importance of the reliability of e-commerce online shopping applications and the current issues related to consumer privacy protection between the blockchain and mobile clients, on this basis, through theoretical analysis and empirical research, consumers The influence of platform-type shopping websites on reliability and consumer shopping behavior factors and mechanisms, blockchain and mobile client privacy protection design investigation and verification forms. The shopping direction identification system of e-commerce consumers has to some extent made up for the shortcomings of previous empirical research on e-commerce trust behavior. In the field of consumer research, e-commerce has the importance of becoming a specific practical indicator.
On the stability of pairs of subharmonic centrifugal pendulum vibration absorbers allowing a rotational mobility
Authors: MAHE Vincent , Renault Alexandre , Grolet Aurélien , Mahé Hervé , Thomas Olivier
Published: January 2023

Centrifugal pendulum vibration absorbers (CPVAs) are passive devices used to reduce torsional vibrations in rotating machines. Previous works showed that a CPVA configuration with two pendulums oscillating in phase-opposition and at half the excitation frequency is efficient in reducing the rotor's vibrations. This paper deals with a new generation of CPVAs, in which the pendulums admit a rotational motion relative to the rotor in addition to the traditional translational motion. The aim of this study is to assess the dynamic stability of a particular subharmonic solution of CPVAs composed of several pairs of pendulum. To do so, a new method based on an analytical perturbation technique is proposed. It leads to more general conclusions than previous studies as the results are derived for CPVAs with any even number of pendulums. The validity of the analytical model is confirmed through a comparison with a numerical resolution of the system's dynamics, and new design guidelines are proposed.
An unusual case of hump-nosed-viper bite complicated with venom-induced thrombotic thrombocytopaenic purpura
Authors: Semina Thisal , Silva Shehan
Published: January 2023

Background: Hump-nosed-viper bites are common in Sri Lanka resulting in nephrotoxicity and coagulopathy. Venom induced consumptive coagulopathy (VICC) is a known complication which occurs in absence of nephrotoxicity.
Case Presentation: We report a case of hump-nosed-viper bite complicating with venom-induced thrombotic thrombocytopenic purpura (VITTP) of a 49 years old previously healthy male. Following envenomation, he developed anuria with acute kidney injury. The blood picture showed microangiopathic haemolytic anaemia with thrombocytopenia while the clotting profile was normal. A plausible diagnosis of VITTP was made per a high PLASMIC score (6/7). The patient underwent therapeutic plasma exchange (TPE) followed by high dose steroids along with renal replacement therapy. He made a full recovery.
Conclusion: VITTP is a manifestation that needs to be differentiated from VICC in hump-nosed-viper bites.
Circularity of resources in the craft brewery segment: an analysis supported by innovation
Authors: Julkovsky Dulcimar José , Sehnem Simone , Lara Ana Claudia , Ramos Maria da Conceição Pereira , Hermann Roberto Rivas
Published: January 2023

This article analyzes how the circularity of resources occurs in Brazilian craft breweries supported by innovation and proposes the creation of alternative craft breweries to promote circular economy. Data were collected through 11 interviews with entrepreneurs in the craft brewery segment, checklist application, and access to the website of the cases investigated. Our results expand the relationship with innovation suggesting that: a) the circularity of resources is still focused on several long-cycle practices; b) short cycles, which are the most desired for the retention of resource value in the production chain, are already present, but demand more attention from the enterprises surveyed; c) innovation practices can become barriers to or drivers for the feasibility of circular economy in the beer context; d) technical cycles are consolidated in most of the researched cases, while biological cycles still demand greater engagement from all stakeholders; e) the nature and content of circular practices imply different adoption stages in the cases investigated; f) companies invest in strengthening the relationship with consumers and suppliers in order to obtain support for current circular strategies in their ventures.
Identification of Hub Genes and Potential ceRNA Networks of Diabetic Cardiomyopathy
Authors: Hou Jun , Liang Wan Yi , Xiong Shiqiang , Long Pan , Yue Tian , Wen Xudong , Deng Haoyu
Published: January 2023

Introduction: Diabetic cardiomyopathy (DCM), a common complication of diabetes, is defined as ventricular dysfunction in the absence of underlying heart disease. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in the development of DCM.
Methods and Results: Weighted Gene Co-Expression Network Analysis (WGCNA) was used to identify key modules in DCM-related pathways. DCM-related miRNA-mRNA network and DCM-related ceRNA network were constructed by miRNA-seq to identify hub genes in these modules.
Results: we identified five hub genes that are associated with the onset of DCM, including Troponin C1 (Tnnc1), Phospholamban (Pln), Fatty acid binding proteins 3 (Fabp3), Popeye domain containing 2 (Popdc2), and Tripartite Motif-containing Protein 63 (Trim63). miRNAs that target the hub genes were mainly involved in TGF-β and Wnt signaling pathways. GO BP enrichment analysis found these miRNAs were involved in the signaling of TGF-β and glucose homeostasis. QCR results found the gene expressions of Pln, Fabp3, Trim63, Tnnc1, and Popdc2 were significantly increased in DCM.
Conclusion: Our study identified five hub genes (Tnnc1, Pln, Fabp3, Popdc2, Trim63) whose associated ceRNA networks are responsible for the onset of DCM.
Analysis of the correlation between climatic variables and Dengue cases in the city of Alagoinhas/BA
Authors: Batista Figuredo Marcos , Souza Monteiro Roberto Luiz , Nascimento Silva Alexandre , de Araújo Fontoura José Roberto , da Silva Andreia Rita , Pereira Alves Carolina Aparecida
Published: January 2023

The Aedes aegypti mosquito is the main vector of dengue and is an extremely synanthropic insect and due to its anthropophilic nature, it has specific reproductive needs. In addition to that, it also needs tropical regions that provide climate-prone conditions that favor vector development. In this article, we propose the cross-correlation analysis between the climatic variables air temperature, relative humidity, weekly average precipitation and dengue cases in the period from 2017 to early 2021 in the municipality of Alagoinhas, Bahia, Brazil. To do so, we apply the trend-free cross-correlation, $\rho DCCA$, being a generalization of the fluctuation analysis without trend, where we calculate the cross correlation between time series to establish the influence of these variables on the occurrence of dengue disease. The results obtained here were a moderate correlation between relative humidity and the incidence of dengue cases, and a low correlation for relative air temperature and precipitation. However, the predominant factor in the incidence of dengue cases in the city of Alagoinhas is relative humidity and not air temperature and precipitation.
Access to genetic diversity in cultivated forage pea (Pisum sativum var. arvense L. ) genotypes through ssr markers
Authors: Ertuş Mehmet Macit , Bezirganoğlu İsmail , Yazıcılar Büşra
Published: January 2023

Background
Forage pea (Pisum sativum var. arvense L.) is an important legume species with high nutritional value used in animal feed nutrition around the world. Forage pea have been grown for animal feeding in the high altitude of the Eastern Anatolia Region for a long time. However, commercial varieties of forage peas are replacing local varieties, especially due to easier seed availability. Therefore, it is aimed in this study is determine of genetic diversity and genome size variation of some forage pea commercial and landraces populations by SSR markers.
Methods and results
This study was carried out in 2021 with 18 populations in cultivated in Turkey. The 11 SSR markers successfully produced total 66 polymorphic bands by percentage of 89,2% for 18 forage pea (Pisum sativum var. arvense L.) populations. The markers produced a total of 66 alleles. These polymorphic alleles were ranged from 3 to 11 with average of 6.
Conclusions
Genetic diversity dendrogram was created forage pea cultivars populations. Generally, seven commercial cultivars and eleven populations of forage pea seperated each other as two main groups. As a result of the study, genetic differences were found between pea varieties, and it was concluded that local varieties should be evaluated in breeding programs.
Ascent Plunge Methods for Seclusion Preserving
Authors: T Arumuga Maria Devi , Sivakumar S
Published: January 2023

The two or more gatherings in possession of private information desire to disclose just the information necessary for collection to a third party. Ascent and descent aim to reduce an objective role so as to grasp only a small minimum. a preliminary implementation of data retirement and conservation with ascension plunge. This essay discusses several malware programmes and how to protect yourself from them. The two techniques, variational approach and least conservative approach, are introduced in the proposed work. The two methods are suggested for safely erecting blocks for both data that is parcelled vertically and that is dispersed on a level plane. As a result, no single festival owns the entirety of the data thanks to an equitable distribution of data or a vertical route.. The existing system that works on horizontally and vertically divided data including two or more gatherings. The secure matrix multiplication is utilized for the calculation for linear regression and arrangement for acting the operation securely. The straight relapse strategy is the one of the most mind-blowing technique for finding the informational collection of client without getting to the confidential information.
The complete genome sequence of andraeanum bacilliform virus, a novel badnavirus encoding the polyprotein through two open reading frames
Authors: Zhou Siqi , Zhou Xiaoyun , He Yiwen , Zhou Guohui , Yang Xin
Published: January 2023

A novel badnavirus, tentatively named as "andraeanum bacilliform virus" (AnBV), was identified in Anthurium andraeanum plants displaying leaf deformation and darkening. The viral complete genome sequence was determined by high-throughput and PCR sequencing. Similar to those of other Badnavirus, the genome of AnBV consists of a circular DNA molecule of 7212 bp with six open reading frames (ORFs) potentially coding for six proteins. Interestingly, ORF3 is split into two parts with a 55-nt intergenic region between them. Similar genome structure was reported in sweet potato pakakuy virus (SPPV) and jujube mosaic-associated virus (JuMaV). Pairwise comparisons of the highly conserved RT/RNase H region revealed the highest amino acid sequence identity (78.6%) to Dioscorea bacilliform AL virus 2 (DBALV-2). Phylogenetic analysis revealed that AnBV and DBALV-2 form a separate clade within the genus Badnavirus, suggesting that AnBV is a novel badnavirus infecting Anthurium andraeanum.
A cuproptosis-related long non-coding RNA risk coefficient model to predict outcomes and therapeutic responses in papillary renal cell carcinoma
Authors: Tang Cheng , Yang Guang , Huang WenLin , Chen Dan , Qu GenYi , Xu Yong
Published: January 2023

Background
Papillary renal cell carcinoma (pRCC) is the second most common subtype of renal cell carcinoma, second only to clear cell renal cell carcinoma (ccRCC). Compared with ccRCC, metastatic pRCC has worse outcomes. Copper is an essential micronutrient; its accumulation is related to cancer proliferation, growth, angiogenesis, and metastasis. The abnormal expression of long non-coding RNA (lncRNA) plays an essential role in developing pRCC. Our study aimed to predict outcomes in pRCC patients using a prognostic risk coefficient model for cuproptosis-related lncRNAs.
Methods
We obtained data from pRCC patients and cuproptosis-related genes from The Cancer Genome Atlas and the literature. Cuproptosis-related lncRNAs were obtained using co-expression analysis based on R language software. The prognostic risk model of cuproptosis-related pRCC was established using univariate and multivariate Cox regressions and LASSO regression analysis, and the model was validated. The high- and low-risk groups were divided by the median value of the risk coefficient. Finally, we performed correlation analysis and potential drug identification for high- and low-risk subgroups.
Results
Seven cuproptosis-related lncRNAs were included (AC019080.5, AC092807.3, AC107464.2, AL5941845.1, GCC2-AS1, NINJ2-AS1, and ZNF710-AS1). Riskscore and tumor stage were independent prognostic factors in pRCC. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway functional enrichment analysis showed that differentially expressed genes in pRCC cuproptosis-related lncRNAs were associated with the pathways of collagen-containing extracellular matrix formation and intracellular and extracellular structure formation. Correlation analysis of immune function showed that type II interferon responses, immune checkpoints, co-inhibition of T cells, cytolysis, co-inhibition of antigen-presenting cells, and human leukocyte antigen were significantly different between high- and low-risk groups. Higher Tumor Immune Dysfunction and Exclusion scores were observed in the low-risk group in the immune escape association analysis, illustrating the suboptimal effect of immunotherapy in low-risk patients. We identified 5-fluorouracil, epothilone B, gemcitabine, paclitaxel, pazopanib, and sunitinib as potentially more beneficial in the high-risk group; bortezomib, erlotinib, and sorafenib were more beneficial in the low-risk group.
Conclusion
We identified seven cuproptosis-related lncRNAs associated with pRCC outcomes and constructed a prognostic model that provides a basis for basic research and pRCC precision treatment.