CHANGES IN THE OPTICAL DENSITY OF VENOUS BLOOD PLASMA IN PATIENTS WITH PATHOLOGY OF DIFFERENT TISSUES OF THE ABDOMINAL CAVITY
Authors: Shurma А.І. , Grynchuk F.V. 
Published: June 2022

Rapid and adequate diagnosis of infl ammatory and destructive injuries of the abdominalorgans is an urgent problem of emergency abdominal surgery. The basis of laboratorydiagnosis in emergency abdominal surgery is to determine the number of leukocytes andtheir forms, the content of C-reactive protein. But the results of such studies are nonspecific. With unclear clinical symptoms, this creates the preconditions for diagnostic errors.To avoid such errors, the determination of the optical characteristics of venous bloodplasma is used. In particular, we studied the optical density of venous blood plasma in theultraviolet spectrum. However, the informativeness of the method was about 86%. Thisneeds improvement. Previous studies of the optical density of venous blood plasma in theinfrared range have shown prospects. Therefore, we conducted new research.The aim of the study – to evaluate the possibility of using the determination of theoptical density of venous blood plasma in the infrared range for diagnosis in emergencyabdominal surgery. The aim of the work is to evaluate the possibilities of using thedetermination of the optical density of venous blood plasma for the diagnosis of acuteinfl ammatory- destructive intra- abdominal pathology.Materials and methods. 42 patients were examined. Among them were: liver abscess –3 cases, acute necrotic pancreatitis – 7, acute intestinal obstruction with intestinalnecrosis – 4, acute edematous pancreatitis – 3, acute phlegmonous appendicitis – 4, acutephlegmonous cholecystitis – 11, unclamped hernia, uncomplicated care – 6.Results. We found in the infrared spectrum a number of maxima of the values of theoptical density of blood plasma, which are localized at wavelengths λ = 365, 555, 620,715, and 770 nm (table). Indicators of optical density at these wavelengths diff ered indiff erent diseases and complications. The obtained results indicate that the optical densityof venous blood plasma in the infrared range varies, depending on the characteristics ofintra- abdominal pathology. At each of the wavelengths, the indicators for diff erent diseasesdiff ered signifi cantly. The most pronounced changes were at wavelengths λ = 365, 555.In all patients with destructive changes in organs (phlegmonous appendicitis, phlegmonouscholecystitis, necrotic pancreatitis, acute intestinal obstruction with intestinal necrosis,liver abscess) in this range were signifi cantly lower in this range. (0.05) than in patientsfrom the control group and in patients with acute edematous pancreatitis. Exceptions werepatients with pinched hernias without intestinal necrosis. The optical density of venousblood plasma in these patients did not diff er statistically signifi cantly from other patients.Conclusions. 1. Patients with diseases of the abdominal cavity at wavelengths = 365-770 nm have characteristic maxima of the optical density of venous bloodplasma, the values of which diff er depending on the type of disease. 2. At wavelengths  =365, 555 nm in patients with destructive changes in organs, the optical density of venousblood plasma is statistically signifi cantly lower (p <0.05) than in most patients withoutdestructive changes in organs. 3. Determination of optical density is a promising area forimproving the diagnosis of acute surgical pathology of the abdominal cavity.