bluuebunny/crossref_metadata_2025 huggingface dataset:
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma
Authors: Ran Longyan , Mou Xiao , Peng Zhenglin , Li Xiaochen , Li Meirong , Xu Duo , Yang Zixi , Sun Xingwang , Yin Tao
Published: November 2022

Background：The third most often diagnosed disease globally and the second most prevalent cause of cancer-related death is colorectal cancer (CRC). Numerous human malignancies have been identified to overexpress ADORA2A. However, it is still ambiguous about its function in CRC.
Methods: RNA-seq with stable transfected SETDB1 knockdown cells was used to identify the differentially expressed genes. Further, knockdown of ADORA2A in CRC cell lines SW620 and HCT116 were performed with siRNA and overexpression of ADORA2A in SW480 cells were conducted with plasmid. CCK8, colony formation, wound healing and transwell assay were used to detect the effects of cell proliferation, migration and invasion after knockdown and overexpression of ADORA2A. Also, apoptosis was analyzed by flow cytometry, apoptosis-related proteins and key PI3K/AKT pathway proteins were detected using western blotting.
Results: ADORA2A was obtained with RNA-seq and played an important role in CRC prognosis. ADORA2A was relatively high expressed in SW620 and HCT116 cell lines compared to SW480 cell line. Knockdown of ADORA2A in SW620 and HCT116 cell lines inhibited cell proliferation, migration and invasion while overexpression of ADORA2A had the opposite results. In addition, ADORA2A also impacted the expression of apoptosis-related proteins, including as Bcl-2, Bax, caspase3 and caspase9, and reduced apoptosis. Furthermore, this process may include the PI3K/AKT signal pathway.
Conclusion: ADORA2A promotes CRC progression by PI3K/AKT signaling pathway. It might contribute to management and treatment of CRC.
IL-37 reduces calcification by inhibiting the oxidized low-density lipoprotein(ox-LDL)-induced toll-like receptor(TLR)/nuclear factor kappa-B(NF-κB) signaling pathway and suppressing cellular osteogenic transformation in smooth muscle cells
Authors: MA ChenYue , CAO YuKun , Wang Meng , HE QiongYi , CHAI Meng , ZHANG HaiTao
Published: November 2022

[Objective] Cardiovascular disease (CVD) is one of the leading causes of high mortality worldwide, and vascular calcification (VC) increases the incidence of adverse prognostic events and mortality in CVD. Osteogenic transformation of vascular smooth muscle cells (VSMCs) and induction of inflammation could be among the mechanisms of VC. Interleukin 37 (IL-37) is an anti-inflammatory factor that protects against atherosclerosis (AS) and VC by unknown mechanisms. Thus, the present study aimed to investigate the effect and mechanism of IL-37 on calcification in human aortic smooth muscle cells (HASMCs).
[Methods] The human aortic smooth muscle cells (HA-SMC) were purchased from CTCC (Meisen, China), Alizarin red S staining was used to measure the degree of cell calcification, flow cytometry measured the level of apoptosis, cell counting kit-8 (CCK-8) measured the cell proliferation activity, and qPCR was used to measure the expression of toll-like receptor(TLR4),nuclear factor kappa-B( NF-κB), Runt-related Transcription Factor 2(RUNX2), Smooth muscle actin(SMA), smooth muscle 22 alpha (SM22α), Msh homeobox 2(MSX2)、Osteocalcin(OC) and alkaline phosphatase (ALP). Western blot measured the level of TLR4, NF-κB, RUNX2, and phosphorylated NF-κB(PP65), and immunofluorescence was used to detect the expression and location of SM22α.Differences were analyzed via Student’s t test or one-way analysis of variance
[Results] Ox-LDL induction caused HA-SMC calcification and promoted HA-SMC apoptosis and value addition. After IL-37 intervention, calcification was significantly reduced, TLR4/NF-κB/RUNX2 expression activated by ox-LDL was decreased, and cell proliferation activity was inhibited, apoptosis rate was decreased, and PP65 expression was downregulated. IL-37 inhibited P65phosphorylation by inhibiting TLR. Down-regulation of osteogenesis-related factor expression plays a protective role against cellular calcification.
[Conclusion] The current data demonstrated that IL-37 inhibits NF-κB phosphorylation by downregulating the ox-LDL-activated TLR4-NF-κ Bsignaling pathway, reduces the expression of the osteogenic transcription factor RUNX2/ALP, and inhibits VSMC osteogenic transformation, thereby reducing the level of cellular calcification. These findings provided a basis for the use of IL-37 as a novel therapeutic target.
Comparison of Postoperative Hypersensitivity between Total Etch and Universal Adhesive System: A Randomized Clinical Trial
Authors: Javed Kiran , Noor Nouman , Nasir Muhammad , Manzoor Manzoor
Published: November 2022

Introduction: Total-etch is multistep but cheaper as compared to a single-step but expensive Universal adhesive. Manufacturers claim that the latest Universal adhesive causes less POH is merely clinically verified. Aim: To determine the mean post-operative hypersensitivity of three-step Total-etch as compared to one-step Universal adhesive on two teeth of the same patient by a qualified dentist. Material and Methodology: Composite restorations were performed on two different teeth of the same patient by applying Total-etch on one and Universal adhesive on another tooth, randomly of 100 patients. Post-operative hypersensitivity (POH) was recorded by visual analog scale before, immediately after, and 24 hours after restoration by using a cold stimulus. An Independent sample T-test was applied. Result: No significant difference was found between the POH of the two bonds before (p-value = 0.7), immediately after (p-value = 0.87), and 24 hours after (p-value = 0.67) the restoration. Discussion: Dentists want POH-free restoration. Claims without verification confuse dentists while selecting adhesives. Conclusion: No significant difference in POH was found when good sample size and proper technique were observed along with the removal of bias like different patients having different pain perceptions and multiple operators having different operating skills. Thus, dentists can choose any bond with convenience.
Detection and classification of liver cancers using computed tomography images
Authors: (M.S.c.) Girma Biniam Solomon , Abebe Argaw Getachew , Teferi Dille Seife
Published: November 2022

Objectives
The aim of this research was to develop an appropriate algorithm-routine that can automatically detect and classify liver cancers from the digital images of CT sample based on the texture and morphological features.
Method
The digital image processing (DIP) provides techniques first for liver image segmentation using semi-automatic technique from the enhanced abdominal CT images and classification using Artificial Neural Network (ANN) through texture features, then the liver tumor automatically extracted from the liver image using Otsu method which is a histogram based thresholding and the classification using ANN through morphological features.
Result
The samples were collected from a number of thirty six diagnosed patients in the procedure of abdominal CT images, at axial view in Black Lion Hospital from DICOM store in Addis Ababa. These images were selected to be processed and analyzed to get best generated result of the predefined classification model based on the extracted features. First nine texture features differentiate 12 normal and 24 abnormal liver images out of the given sample’s containing 36 images then tumor images extracted from the 24 abnormal images, the ANN classifier using six morphological features classified the 24 abnormal liver images as benign and malignant. It’s result presented by confusion matrix and showed that the maximum accuracy rate for tumor classification was 95.8%. The performance can be increased more by increasing the number of samples.
Conclusions
The outcome of this research work help radiologists to follow the condition of diseases at early stages and classify tumor as benign and malignant. It also helps in decreasing the rate of presence of disease by detecting cancer in its earlier stages.
Prioritized experience replay in DDPG via multi-dimensional transition priorities calculation
Authors: Cheng Nuo , Wang Peng , Zhang Guangyuan , Ni Cui , Gong Hui
Published: November 2022

The path planning algorithm of intelligent robot based on DDPG uses uniform random experience replay mechanism, cannot distinguish the importance of experience samples to the algorithm training process, and has some problems, such as unreasonable sampling of experience transitions and excessive use of edge experience, which lead to slow convergence speed and low success rate of path planning. In this paper, The priorities of experience transition based on the immediate reward, temporal-difference (TD) error and the loss function of Actor network are calculated respectively, and the information entropy is used as the weight to fuse the three priorities as the final priority. Furthermore, in order to effectively use the positive experience transitions and ensure the diversity of experience transitions, a method of increasing and decreasing the priority of positive experience transition is proposed. Finally, the sampling probability is calculated according to the priority of experience transition. The experimental results show that our proposed prioritized experience replay can not only improve the utilization rate of experience transitions and accelerate the convergence speed of DDPG, but also effectively improve the success rate of path planning, so as to provide a better guarantee for the robot to safely reach the target point.
Identification and Validation of Lipid-related Genes in Acute Myocardial Infarction
Authors: Liu Zheng-Yu , Liu Fen , zheng Peng-Fei , Cao Yan , Pan Hong-Wei , Peng Shao-Liang , Hong Xiu-Qin
Published: November 2022

Lipid metabolism plays an essential role in the genesis and progress of acute myocardial infarction (AMI). Herein, we identified and verified latent lipid-related genes involved in AMI by bioinformatic analysis. Lipid-related differentially expressed genes (DEGs) involved in AMI were identified using the GSE66360 dataset from the Gene Expression Omnibus (GEO) database and R software packages. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted to analyze lipid-related DEGs. Lipid-related genes were identified by two machine learning techniques: least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM-RFE). The receiver operating characteristic (ROC) curves were used to descript diagnostic accuracy. Furthermore, blood samples were collected from AMI patients and healthy individuals, and real-time quantitative polymerase chain reaction (RT-qPCR) was used to determine the RNA levels of lipid-related DEGs. Fifty lipid-related DEGs were identified, 28 upregulated and 22 downregulated. Several enrichment terms related to lipid metabolism were found by GO and KEGG enrichment analyses. After LASSO regression and SVM-RFE screening, four genes (ACSL1, CH25H, GPCPD1, and PLA2G12A) were identified as potential diagnostic biomarkers for AMI. Moreover, the RT-qPCR analysis indicated that the expression levels of these four lipid-related genes in AMI patients (n = 50) and healthy individuals (n = 50) were consistent with bioinformatics analysis results. There were 4 key lipid-related genes were identified associated with AMI using machine learning. The validation of clinical samples suggested that ACSL1, CH25H, GPCPD1, and PLA2G12A are expected to be diagnostic markers for AMI and provide new targets for lipid therapy of AMI.
EPMA quantification on the chemical composition of retained austenite in a Fe-Mn-Si-C-based multi-phase steel
Authors: Heo Yoon-Uk , Jeong Chang-Gon , Kim Soo-Hyun , Yoon Gun-Young , Trang T. T. T. , Woo Youngyun , Yoon Eun Yoo , Lee Young-Seon
Published: November 2022

An electron probe X-ray microanalyzer (EPMA) is an essential tool for studying chemical composition distribution in the microstructure. Quantifying chemical composition using standard specimens is commonly used to determine the composition of individual phases. However, the local difference in chemical composition in the standard specimens brings the deviation of the quantified composition from the actual one. This study introduces how to overcome the error of quantification in EPMA in the practical aspect. The obtained results are applied to evaluate the chemical composition of retained austenite in multi-phase steel. Film-type austenite shows higher carbon content than blocky-type one. The measured carbon contents of the retained austenite show good coherency with the calculated value from the X-ray diffraction.
The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis
Authors: Zhan Han-xiang , Meng Yu-Fan , Fan Zhi-Yao , Yang Jian , Li Yong-Zheng , Liu Shu-Jie , Gao Chang-Hao
Published: November 2022

Background： The role of dyslipidemia in pancreatic neuroendocrine tumors (PanNENs) is unclear. The aim of this study is to analyze the characteristics of serum lipid spectrum in PanNENs, and the effect of the variation in lipid profile on the development of PanNENs clinicopathological features and prognosis.
Methods All PanNENs patients between November 2012 and September 2020 in the authors' research center were identified from patient medical records and database. Clinicopathologic features, serum lipid level and overall survival results were retrospectively analyzed using statistical methods.
Results： This retrospective cohort study displays that insulinoma patients exhibits increased serum HDL level compared to non-functional PanNENs (OR:2.522; 95% CI:1.096-5.803; P = 0.030). High levels HDL were negatively correlated with tumor diameter (OR 0.233; 95% CI: 0.069-0.790; P=0.019). However, there was no significant difference between PanNENs patients with hyperlipidemia and normal blood lipid level in tumor location, tumor diameter, pathological grade, and clinical stage. In the univariate and multivariate analyses, there is also no significant correlation between hyperlipidemia and overall survival.
Conclusions： HDL was negatively correlated with the tumor size of PanNENs. Although the serum HDL level of insulinoma patients is higher than nonfunctional PanNENs, dyslipidemia may not be an independent predictor of survival outcome.
Psychological barriers to the use of opioid analgesics for treating pain in patients with advanced recurrent cancer (BAROC): a multicenter cohort study
Authors: Tsuno Takehiko , Kawaguchi Takashi , Yanaizumi Ryota , Kondo Junichi , Kojima Keiko , Igarashi Takashi , Inoue Masaki , Miura Tomofumi , Miyasato Akime , Azuma Kanako , Hamada Hiroshi , Saeki Tomoya , Mawatari Hironori , Ogura Hiroyuki , Kotani Akira , Yamaguchi Takuhiro , Hakamata Hideki
Published: November 2022

Purpose
We aimed to gain insight into psychological barriers towards initiation of strong opioid analgesic use in patients with advanced, recurrent cancer.
Methods
This study included 46 patients who were prescribed with opioid analgesics for advanced, recurrent cancer. The primary outcome was psychological barriers assessed using the Japanese version of the Barriers Questionnaire-II (JBQ-II). The secondary outcomes were psychological changes and pain relief 1 week after the induction of strong opioid analgesics.
Results
The mean (S.D.) age of participants was 63.6 (11.1) years. Further, 26.1% had an Eastern Cooperative Oncology Group (ECOG) performance status of ≥ 3. The mean JBQ-Ⅱ total score was 1.97 (95% confidence interval: 1.75, 2.19). At the initiation of opioid therapy, there was no difference in the total scores between the baseline and 1 week later. Nevertheless, there was a significant difference in the subscale “disease progression” score (mean 2.97 vs 2.59, difference in means 0.38, standard error 0.16, p = 0.026). Personalized Pain Goal (PPG) was achieved in about half of the participants, and a trend toward a higher score in the subscale “harmful effects” (concern about adverse events) was observed in those who did not achieve PPG.
Conclusion
This study showed that patients with advanced, recurrent cancer have psychological barriers to opioid induction. The relationship between the presence of psychological barriers before and after induction of opioid analgesics and the speed of pain improvement was determined. The results may provide fundamental information for prospective intervention studies to develop individualized education programs for patients with psychological barriers to opioids.
Recovery Period of Air Transportation: Vector Error Correction Model
Authors: İnan Tüzün Tolga
Published: November 2022

Air transportation has two significant modules named air passenger and freight. Air transport is the primary module of civil aviation and because of its nature, air transport has been simultaneously affected by Pandemics and crises. Gulf Crisis, 9/11, 2008–2009 Financial Crisis, SARS, and MERS Pandemics harm air transport, however, the influence of COVID-19 was more devastating than the other Pandemics and crises due to its global effect. This effect has continued a long period that still this effect exists now with a slight trend. The aim of this study is to analyse the selected variables that shows the past and future trend of air transportation related to operational and financial status. These variables are the primary ones that can define the countries' general status in air transport. The forecasting results are examined by 9-months forecasting with Vector Error Correction Model. It is forecasted that slightly decreasing trend will proceed in the following 9-months for passenger transportation due to fall and winter seasons. It is forecasted that slightly upward trend will proceed in the following 3-months and slightly decreased in the other 6-months for cargo transportation due to potential economic crisis in 2023. The originality of this paper is the first research related to analyse passenger and freight transportation together with the operational and financial parameters that defined in the sample of data and methodology sections.
Insurance Coverage of Dermabrasion and Chemical Peel Procedures: A Critical Analysis of 58 American Insurance Companies
Authors: Ha Michael , Finkelstein Emily R. , Wieland Mark , Qadri Aasheen , Brown Madeline , Ejimogu Jason , Rasko Yvonne M.
Published: November 2022

Background: Dermabrasion and chemical peels are infrequently utilized methods of treatment for medical grade conditions despite demonstrations of favorable outcomes. This may be due to the discrepancy of insurance coverage for these procedures.
Objective: To evaluate the frequency of insurance coverage for dermabrasion and chemical peel procedures in the treatment of acne, acne scarring, and non-melanoma skin cancers (NMSC).
Methods and Materials: A cross-sectional analysis of 58 insurance companies by web-based search or phone interview determined the number of insurers with a publicly available policy on dermabrasion or chemical peels. For each policy, the coverage status and any corresponding criteria were extracted.
Results: Dermabrasion to treat basal cell carcinoma and actinic keratosis was discussed by 13 (16%) and 21 (36%) insurers respectively. Twenty of twenty-three companies (87%) with a chemical peel policy for premalignant lesions provided coverage. Of the 25 companies (43%) that discussed treatment of acne with chemical peels, 14 (56%) provided reimbursement and 11 (44%) denied coverage. Coverage of acne was denied significantly less for chemical peels than for dermabrasion (p<0.006).
Conclusion: Inconsistencies in both inclusion and coverage between insurance companies may create an artificial barrier to receiving care.
Pre-Service Teachers’ Evaluation of the Student Internship Program: Basis for Design Improvement
Authors: Lobo Joseph
Published: November 2022

This descriptive-survey study aimed to evaluate the implementation of the institute at City College of Angeles. Obtained data for this study were solicited via judgment sampling from 84 pre-service teachers from the Bachelor of Physical Education and Bachelor of Performing Arts programs who had their internship last academic year 2021–2022. Descriptive statistics such as frequency, mean and standard deviation were used to describe the quality of the internship program based on institutional and company evaluation, program effectiveness, and thematic analysis for the comments and suggestions of students on the internship program offered. Based on the results, the internship program of the institute is very effective since it is responsive to the community's needs, and students develop skills needed for their careers. On the other hand, the deployment of students to various public schools emerged as the central theme based on the results. On a positive note, pre-service teachers highly appreciate the internship program. The results of this study are expected to improve the program design of the pre-service teachers of the institute. Regular review of the curriculum and offered courses matching the needs of the industry should be performed. Additionally, the recommendation on the possibility of forging linkages with other private schools and industries related to the program is a result of this study. Also, formulation and development of the institutional policies and guidelines of the program or deployment manual, which may serve as a reference for pre-service teachers, is highly suggested.
Estimation of height in a quilombola community in northeastern Brazil using anthropometric measurements of the hands
Authors: Aragão José Aderval , Sacramento Erick Mendonça do , Marcelo Israel Santos , Aragão Iapunira Catarina Sant’Anna , Aragão Felipe Matheus Sant’Anna , Reis Francisco Prado
Published: November 2022

Background
Estimating or predicting height, using fragments of the body or components of the human skeleton, for this purpose, originates from the idea of proportionality between the different parts of the body. The aim of this study is to estimate height from anthropometric measurements of the hands (length and width). The sample consisted of 300 individuals from a quilombola community in northeastern Brazil, 150 males and 150 females. All people from the quilombola community, enjoying good general health, were included, and those people who, presented deformities of the hand, spine and lower limbs were excluded.
Result
The correlation coefficients between height and hand length values were positive and moderate. As for females, the correlation between height and lengths of the right and left hands were respectively 0.574 (p < 0.0001) and 0.612 (p < 0.0001).
Conclusion
The measure that best correlated with height in the quilombola community in northeastern Brazil was hand length for both sexes, with the highest correlation for females.
Multi-Pollutant Water Quality Trading: An Approach for Groundwater Quality Management in Varamin Plain, Iran
Authors: Souri Mohammad Amin , Jamshidi Shervin , Moghaddam Hamid Kardan
Published: November 2022

Groundwater quality management is challenging due to the fate and transport of multiple pollutants in the porous media, extensive polluters, and late aquifer responses to pollution reduction practices. Water quality trading (WQT) is a regionally incentive-based strategy for self monitoring and groundwater quality improvement. This study evaluates the effectiveness of 12 waste load allocation (WLA) scenarios on groundwater nitrate and chloride abatement, simultaneously using MODFLOW and MT3D. The theoretical efficiencies of multi-pollutant WQT are also testified out of these WLA policies by considering environmental, economic and practical conditions. For these purposes, Varamin plain, south eastern Tehran, Iran was chosen as the study area where both point and non-point emission sources were considered in WQT. At first, an allowable groundwater quality limit (AQL) was set for pollutants regarding groundwater impairment and simulation outcomes. The AQL violations of WLAs were then calculated in addition to their marginal abatement costs and penalties. Here, nitrate abatement ranges between 3.3–15.3% while chloride abatement ranges between 4.5–23.6%. However, 5 WLA scenarios could pass the conditions of not violating any AQLs, and gaining remarkable benefits (> 25%) for all market attendants. Potential WQT strategies are finally prioritized regarding their viability and marginal costs. According to these conditions, trading discharge permits between WWTPs with 25% nitrate removal (sellers) and current farmers (buyers) is recommended as the optimal WQT alternative which imposes no penalties or land-use changes. Here, the overall benefits of sellers and buyers exceed 42% and 85%, respectively in comparison with not attending at any WLA scenario.
Study of promotor -21 A/T polymorphism of catalase CAT (rs7943316) gene in patients with breast cancer
Authors: Abdulabbas Hadi Sajid , Al-Mawlah Yasir Haider , Shaheed Salah Hashim , Jebor Mohammed Abdullah , Ali Suroor Mohammed
Published: November 2022

Oxidative stress is implicated in many forms of cancer, and catalase is one of the most critical enzymes involved in the organic body's defensive mechanism against stress on antioxidation. Catalase shows a vital role in the body's primary defense versus oxidative stress. Several studies have indicated that CAT gene polymorphism plays an essential role in the pathogenesis of cancer. This study aimed to recognize the influence of the CAT (rs7943316) gene polymorphism on breast cancer progress in patients using a collection of blood samples from each subject. After the extraction of genomic DNA, the SNP rs7943316 analysis was performed using PCR, RFLP, and electrophoresis on agarose. finally visualized under UV light and analyzed with SPSS software (version 23). This study revealed that the higher genotype in the control subjects was AT genotype 19 (63.3%), followed by TT genotype 11 (36.7%), and AA genotype (0%). In the BC group, AT genotype was the higher 39 (55.7%), followed by TT genotype 24 (34.3%), and AA genotype 7 (10.0%). Individual carriers of the A/T and T/T type of genotype were less expected to develop BC [OR = 0.135, 95% CI = 0.0073-2.4882, P value = 0.178] and [OR = 0.1420, 95% CI = 0.0075-2.70, P value = 0.1943], respectively. In addition, there are no significant differences in frequencies of the T allele of the CAT gene (rs7943316) between breast cancer patients and control groups [OR = 0.67, 95% CI = 0.4002-1.4459, P value = 0.4039]. In brief, the current study’s results suggest no correlation between rs7943316 polymorphisms of CAT genes and the development of BC; the genotypes AA, AT, and TT have no potential risk for breast cancer in patient women.
Rare Nodular Lesion on Gingiva - Peripheral Odontogenic Fibroma
Authors: Cardoso Camila Lopes , Teixeira Letícia Maria Pereira , Duarte Gabriel Lúcio Calazans , Silveira Heitor Albergoni , Costa Beethoven Estevao , Freitas Filho Silas Antonio Juvencio de , Consolaro Alberto , Ribeiro Júnior Paulo Domingos
Published: November 2022

Peripheral odontogenic fibroma (POF) is a rare lesion, the extraosseous counterpart of the odontogenic fibroma, an odontogenic tumor of ectomesenchymal origin. Clinically it resembles as the reactional processes and has slow growth. The purpose of the study is to present a clinical case of posterior maxillary POF mimicking inflammatory periodontal disease in a 42-year-old woman who, after complete surgical excision, is followed up every six months without recurrence of the lesion. POF is a lesion characterized by fibroblast proliferation containing portions of apparently inactive odontogenic epithelium. The surgical treatment, when well performed, presents a very favorable prognosis, with a rare chance of relapse. It is important to emphasize that all the gingival lesions should be submitted to the anatomopathological examination, and the radiographic examination of the region is fundamental to evaluate the extent of the lesion.
Traumatismo Dentário na Infância: Conduta de Professores do Ensino Fundamental Público do Sertão de Pernambuco
Authors: Ferraz Thays Maria Ramalho , Mourato Ivana Tamires Pires , Queiroz Virgínia Karla Pinheiro de , Melo Jéssica Gomes Alcoforado de , Filgueira Pedro Tardelly Diniz , Magalhães Vinicius Souto , Soares Diego Moura
Published: November 2022

Introdução: Os traumas dentários são lesões frequentes na infância e o atendimento imediato garante o melhor prognóstico. Em consequência disso, é fundamental que os professores, que passam um período com essas crianças, tenham o conhecimento sobre ações a serem realizadas em casos de traumatismos dentários. Objetivo: Dessa maneira, a pesquisa objetivou avaliar o nível de conhecimento dos professores do ensino fundamental da rede pública da cidade de Serra Talhada-PE, sobre condutas a serem tomadas em situações de trauma dentário na infância. Material e Método: Para avaliação foi utilizado um questionário estruturado, aplicado em 17 escolas do município. O questionário composto por I- dados pessoais e profissionais, experiência e informação prévia em traumas dentoalveolares; II- conhecimentos gerais sobre traumatismo dentoalveolar e fraturas dentárias. Os dados obtidos foram tabulados e analisados utilizando o SPSS 16.0. Uma amostra não probabilística, formada por 100 professores compôs este estudo. Resultados: Apenas 27% dos professores já tinham recebido algum tipo de informação acerca de trauma dentário. Sendo deste, 15% receberam informação em consultas odontológicas. Da mesma forma 40% dos participantes relataram algum tipo de experiência com trauma dentoalveolar. A média de conhecimento dos professores foi 3,16 (±1,23) sendo a mínima 0 e a máxima 7. Não houve diferença estatística nas médias de conhecimento para aqueles que apresentavam experiência prévia. Conclusão: Os professores demonstraram pouco conhecimento sobre os procedimentos de urgência a serem realizados nos casos de traumatismo dentário. Perante o exposto, é necessário capacitar esses profissionais para realizar o manejo inicial adequado.
Polish veterinarians - victims of the Katyn Massacre. Martyrology of the Polish War Cemetery in Kharkov
Authors: ŻWANKO LUBOW , KIBKAŁO DMYTRO , JAŚKOWSKI JĘDRZEJ M. , SOBOLEWSKI JAROSŁAW
Published: November 2022

The purpose of this study is to present the profiles of fifty-seven Polish veterinary surgeons, prisoners of the Starobielsk camp, murdered at the headquarters of the Kharkov NKVD Board in late April and early May 1940 and buried at the Polish War Cemetery, Cemetery of Victims of Totalitarianism in Kharkov. In the article, the authors provide a brief historical outline of the Red Army’s invasion of Poland in September 1939 and the motives leading to the Katyn Massacre. The main part of the article contains a list of names of Polish veterinary surgeons, victims of the Katyn Massacre, together with biographical notes. It highlights the fact that during the ongoing war in Ukraine, the cemetery, as a place of Polish memory, was bombed by the Russians with cluster bombs. It is also important to assume that after the end of the current war, the Polish War Cemetery in Kharkov will probably become the only memorial of the Katyn Massacre on the territory of the former USSR.
Preparation of sodium alginate films incorporated with hydroalcoholic extract of Macrocystis pyrifera L.
Authors: Ramos Judith , Villacrés Nelson Adrián , Cavalheiro Éder Tadeu Gomes , Alarcón Hugo A. , Valderrama Ana C.
Published: November 2022

Agroindustry needs novel materials to replace synthetic plastics. This article introduces sodium alginate films with antioxidant properties. The films, which were incorporated with hydroalcoholic extract of Macrocystis pyrifera L., were tested on sliced Hass avocados.

The research featured sodium alginate films incorporated with hydroalcoholic extracts of M. pyrifera. Uncoated avocado halves served as control, while the experimental samples were covered with polymer film with or without hydroalcoholic extract. A set of experiments made it possible to evaluate the effect of the extracts on polymeric matrices, release kinetics, and sensory profile of halved Hass avocados.

A greater concentration of hydroalcoholic extracts increased the content of phenolic compounds and their antioxidant activity. As a result, the bands in the carboxylate groups of sodium alginate became more intense. Crystallinity decreased, whereas opacity and mass loss percentage increased, and conglomerates appeared on the surface of the films. These processes fit the KorsmeyerPeppas kinetic model because they resulted from a combination of diffusion and swelling mechanisms in the films.

The films incorporated with hydroalcoholic extract of M. pyrifera proved to be an effective alternative to traditional fruit

wrapping materials.
The Integration of Transportation Modes for Bromo-Tengger-Semeru National Park
Authors: Priyambodo  , Hamid Abdul , Buditiawan Kristian , Setyawan Dendy , Adi Ari Sasmoko , Gartika Dewi , Suroso  , Alita Endriana Wahyu , Momon
Published: November 2022

Introduction:

The spread of the COVID-19 virus requires unprecedented steps from the government such as the restriction of travelers and activities and enforcement of social distancing to reduce interaction between individuals. This led to a drastic decrease in tourist visits to the TN-BTS between January and December 2020 with the area reported having been closed between April - July. Meanwhile, there was an inadequate transportation system at a tourist destination area before the pandemic and that made the movement more difficult during the pandemic. Therefore, this research is focused on describing transportation modes integration in the East Java-Indonesia TN-BTS area during this period.

Methods:

The intermodal integration was represented through the community's preference which was based on certain elements such as the need for connecting mode, main mode, multimodal network, transitional facilities, switching facilities with different networks, schedules integration, tariffs, routes, and times.

Results and Discussion:

The survey conducted, however, showed these indicators are below expectation as observed with the community satisfaction with transportation integration in the TN-BTS area measured to be very low, below 60%, using the Customer Satisfaction Index (CSI) tool. Moreover, the expectations on the variables for intermodal integration were also measured using Important Performance Analysis (IPA).

Conclusion:

The findings showed the policymakers and planners need to take steps to encourage the realization of transportation integration in the TN-BTS area to develop tourism in the area.
Quality of Bali beef cut on different management of slaughterhouses (RPH) in Bali province
Authors: Sriyani N. L. P. , Sampurna I Putu , Dewi Gusti Ayu M. K. , Sumardani N. L. G.
Published: November 2022

The purpose of this study was to determine the physical, chemical and microbiological quality of Balinese beef from Slaughterhouses (RPH) with different management in Denpasar City and Badung Regency as abattoirs that supply most of Bali beef on the island of Bali. The material used was male Bali beef in the Longisimus Dorsi (LD) muscle which was cut at three different abattoirs. The RPH are UPT RPH Mambal, UPT RPH Pesanggaran and RPH belonging to the community of RPH Darmasaba in Banjar Bersih Darmasaba Village. This study used a completely randomized design (CRD) with 3 treatments where three abattoirs were treated and each treatment consisted of 10 repetitions of Bali beef cuts. The variables sought in this study were physical quality variables, namely pH, color, water holding capacity, and meat cooking loss. Chemical quality variables are meat moisture content, protein content, fat content and ash content. Meat microbiological variables were TPC, colliform, e-coli and salmonella. The results showed that the physical quality of Bali beef slaughtered at the Darmasaba RPH had the lowest physical quality compared to the Mambal and Pesanggaran abattoirs, especially on the pH and meat color variables. The chemical quality of Bali beef slaughtered at the three abattoirs had no significant difference in water content, protein content, and ash content. The total plate count, coliform was below the SNI threshold while e-coli was not identified and salmonella was negative.
COMPORTAMIENTO, GLANDULAS ACCESORIAS Y CENTROS NEUROENDOCRINOS EN MACHOS DE DOS ESPECIES DE CANTHON (COLEÓPTERA: SCARABAEINAE)
Authors: Acta Zoológica Mexicana
Published: November 2022

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"Li buffoni", Fessa e la nuova malmaritata di Margherita Costa
Authors: Goethals Jessica
Published: November 2022

La prima commedia pubblicata in Italia da una donna fu Li buffoni di Margherita Costa (1641). Commedia ridicolosa, l’opera è una parodia della corte Medicea ambientata in nord Africa. Il presente studio considera la protagonista Marmotta, principessa di Fessa e moglie del principe di Marocco, come una rivisitazione innovativa del topos della malmaritata. Essa non è la moglie annoiata e adultera o la giovinetta desiderosa di evitare un’unione sgradita, ma una sposa i cui appetiti amorosi rimangono insoddisfatti perché il marito preferisce la compagnia di nani, gobbi, matti e altri ‘scherz[i] di natura’ del principato. Il saggio legge Li buffoni come una sfida fatta da una scrittrice ai luoghi comuni del mondo teatrale sul desiderio femminile. 

Keywords: Margherita Costa, «malmaritata», gender, burlesco, commedia
Conceptualizing Early Modern Metropolitan Space in Giovan Battista della Porta’s Comedy "Tabernaria" (1616). The Osteria del Cerriglio in Naples
Authors: Kodera Sergius
Published: November 2022

This contribution examines a particular instance in which two different ways of perceiving metropolitan space in 17th century Naples (espace véçu and espace conçu) become imbricated in the mode of comedy. Tabernaria stages not merely the place of the Osteria del Cerriglio, a historic urban site; through a characteristic mise en abîme, this scenic re-creation is doubled or mirrored in a theatrical place which only pretends to be the Cerriglio. Likewise, and again typical for this narrative strategy, the staged play itself is doubled by the ruse enacted by some of the personae for (or rather: against) other personae onstage. The audiences may then enjoy this oblique representation of a very real metropolitan space and its labyrinthine pitfalls, from a safe distance. 

Keywords: Naples, theater and space, espace véçu, espace conçu, Baratta map
Aproximación a las críticas portuguesas del siglo XVIII sobre poesía barroca Política, ideología y transición del gusto
Authors: Miranda Alma Delia
Published: November 2022

El objetivo de este trabajo es revisar las opiniones sobre la poesía barroca vertidas en paratextos de la Fénix Renascida, así como en revisiones del estado de la poesía portuguesa en el siglo XVIII: Carta VII del Verdadeiro Método de Estudar, de Luís António Verney; algunas de las Orações y Dissertações de Correia Garção; Nova arte de conceitos, de Leitão Ferreira; y Exame crítico de Valadares Sousa, y dilucidar si las motivaciones de estas ideas son de tipo político, ideológico o estético. 

Keywords: Poesía barroca, Luís António Verney, Correia Garção, Nova arte de conceitos, Exame crítico.
Gongorismo, religión y política en Luis de Tovar
Authors: Alonso Álvaro
Published: November 2022

El presente trabajo se centra en el casi desconocido poeta portugés Luis de Tovar, autor de un poema épico en castellano sobre San Antonio de Padua. Tomando como punto de partida el poema, se intenta precisar cuáles fueron las relaciones de su autor con la monarquía de los Austrias y su capital, Madrid, durante el reinado de Felipe III. El profundo apego de Tovar a su patria no implica en él anticastellanismo ni hostilidad hacia la dinastía reinante, aunque sí parece haber lamentado el progresivo incumplimiento de los acuerdos de Tomar. Su intensa relación con España se refleja también en el plano literario, ya que Tovar debe mucho a la poesía de Góngora y, en particular, a las Soledades. 

Keywords: Luis de Tovar, Góngora, épica culta, Monarquía Dual, Madrid, identidad portuguesa.
Versos para un pequeño príncipe de Portugal
Authors: Álvarez-Cifuentes Pedro
Published: November 2022

El nacimiento del futuro D. Pedro II de Portugal, el último hijo de los reyes D. João IV de Bragança y D.ª Luisa de Guzmán, fue festejado con grandes fastos y celebraciones. En el contexto jubiloso de la Restauração de la independencia de Portugal, los poetas de la corte lisboeta se esmeraron en ensalzar a la Casa de Bragança como nueva dinastía real, tanto en portugués como en otras lenguas. Se propone una contextualización y análisis de las publicaciones poéticas que aparecieron en 1648 con motivo del nacimiento del nuevo príncipe: el Jardim de Fanimor de Diogo Ferreira Figueiroa, el Aplauso Ulysiponense de Manuel Gomes Serrano, y los Varios versos ao felix nacimento do serenissimo infante Dom Pedro Manoel de la Academia dos Generosos. 

Keywords: Restauração, poesía panegírica, Academia dos Generosos, Casa de Bragança, D. Pedro II.
Portugueses ilustres en los paratextos de Lope de Vega: las dedicatorias a Ferreira y Sampayo (1620), Rodrigo Mascareñas (1623) y Faria y Sousa (1625)
Authors: García Aguilar Ignacio
Published: November 2022

En el período 1620-1625 Lope de Vega introduce y desarrolla una innovación paratextual en sus recopilaciones de comedias adocenadas, consistente en la inclusión de una dedicatoria al frente de cada una de las doce obras teatrales compendiadas en sus volúmenes. Con esta multiplicación de los dedicatarios persigue obtener ventajosos réditos por parte de importantes agentes del sistema literario de su época. Del casi centenar de dedicatorias teatrales que redactó durante este lustro, únicamente tres se dirigen a ingenios portugueses. El presente trabajo examina esos paratextos y los interpreta atendiendo a las estrategias que desarrolla el Lope de senecute en el marco de su complejo contexto histórico-literario. 

Keywords: Lope de Vega, dedicatorias, paratextos, Partes de comedias.
THE UTILIZATION OF SEA WATER IN A ESPECIALLY DESIGNED BATTERY (SABRINE SWALL BATTERY)
Authors: - Mursyidah , Susanto Adhi , BS Isnaeni
Published: November 2022

Batteries are chemical devices to save electricity. device capable of generating a DC voltage, ie by converting chemical energy contained in it into electrical energy through the reaction of electro clams, Redox (Reduction - Oxidation). The battery consists of several cells, these cells become energy storage in the form of chemical energy. Negative electrode called the cathode, which serve as electron donors. Positive electrode called the anode which serves as an electron acceptor. Between the anode and the cathode current will flow from the positive pole (anode) to the negative pole (cathode). While the electrons will flow from ktoda toward the anode.In this study, the batteries are designed to use sea water as electrolyte. Voltage measured for one cell is 0,75 Volt and measurable current of 100mA, to get the required voltage is 10 Volts 15 cells arranged in series. Testing is done by loading a flashlight with 5 LED, the results of this special design battery capable of powering 5 LED for seven days without stopping, this suggests that there are large energy stored in batteries. After charging the battery energy runs out of energy again just by replacing the sea water as electrolyte. These batteries are designed to be placed in the beach area and waterfront, it is intended that the sea water needs as the electrolyte can be easily obtained. The especially designed battery is one of the low technology and easy to be made, because the necessary materials readily available in the manufacture of batteries, the battery does not require extra maintenance, environmentally friendly and can be used for twenty-four hours as long as there is sea water.
STUDI PERBANDINGAN PERLAKUAN BAHAN BAKU DAN METODE DISTILASI TERHADAP RENDEMEN DAN KUALITAS MINYAK ATSIRI SEREH DAPUR (Cymbopogon citratus)
Authors: - Slamet , - Supranto , - Riyanto
Published: November 2022

Indonesia is rich in plant biodiversity. Indonesia volatile oil development efforts through increased development of one plant of lemon grass, which is one of the essential oil producing plants known as Cymbopogon citratus. Lemongrass essential oil in the chemical industry used as raw materials in the manufacture of cosmetics, perfume, deodorant, deodorant soap, floor cleaners and detergents.The purpose of this study was to determine the highest yield of lemongrass essential oil distillation using the method of water distillation, water-steam, and steam to the treatment of intact leaves and chopped leaves and know the quality of essential oil of lemongrass with the treatment of raw materials and different methods of distillation, the design used by two factors: variation in the treatment of raw material (whole leaves and chopped leaves) and the distillation process variation (distilled water (boiled), water-steam distillation and steam distillation. Data obtained from the analysis of yield, specific gravity, refractive index, and oil content of the compound citral essential (lemongrass oil).This study uses three methods of distillation, the distillation of water, water-steam distillation and steam distillation is carried out on samples of intact leaves and chopped leaves of fresh lemongrass. The results yield calculation and testing of physics and chemistry, as well as in the method of analysis SPSS One-Sample Test Statistics for the lemongrass essential oil products.Based on the  results of research on the treatment of raw materials and distillation methods can be concluded that the treatment of raw materials lemongrass intact leaves with water distillation method (boiled) at both the content yield 0.52%, 71.84% citral, specific gravity 0.8967 g/mL, and the refractive index of 1.4905. It is appropriate to mention that SNI 06-39-53-1995 yield 0.3%, the specific gravity of 0.8731 g/mL, and the refractive index of 1.4586. But the content of citral not meet SNI standards are 76.1%, but according to Guenther (2006) which states citral content of between 65% to 85%.
PEMANFAATAN ZEOLIT DIAKTIFKAN DENGAN LARUTAN ASAM UNTUK PEMURNIAN BIODIESEL
Authors: Furqon Muhammad Hidayat , Prasetya Agus , Wilopo Wahyu
Published: November 2022

Utilization of zeolite activated by acid solution for biodiesel purification has been done. This research is conducted to find the mechanism of biodiesel purification from catalyst with activated zeolite, the effectiveness of the activated zeolite of various particle size, soaking time and purification temperature, the economic feasibility of biodiesel production by using this method and the more economical method by comparing the cost and performance of biodiesel purification using activated zeolite and using water and acid solution.This research has used cooking oil, methanol and sodium hydroxide to make biodiesel, sulfuric acid as activator and zeolite from Gunung Kidul which is filled into wash column with support from vacuum pump to purify biodiesel. The variable of the research is particle size of zeolite among others: 12 mesh <De< 20 mesh, 20 mesh <De< 40 mesh and 40 mesh <De< 80 mesh, soaking time 0, 15 minutes, 30 minutes, 1 hour and 2 hours, and purification temperature 27oC, 40oC and 60oC.Mechanism of activated zeolite for purifying biodiesel from catalyst has been investigated that activated zeolite is using the absorption rate where catalyst will fill the empty pores of zeolite and its cation exchange capacity where it will exchange cation in zeolite surface with cation of catalyst so that zeolite can purify the unwashed biodiesel from catalyst. Optimization of biodiesel purification using zeolite activated by acid solution method can be achieved with particle size of the zeolite 20 mesh <De< 40 mesh, 30-minute soaking time and purification temperature at 27oC. Economic analysis of the use of zeolites in the optimum condition within one year resulted Payback Period 8.68 months, Benefit Cost Ratio 1.86, Net Present Value Rp 431,173,257.44 and Return of Investment -138 % and the use of zeolite activated by acid solution more economical than the use of water and acid solution as purifying biodiesel because of cost savings can be made up to 86% of method of using water and acid solution.