bluuebunny/crossref_metadata_2025 huggingface dataset:
Sulfone Syndrome: A Unique Delayed Type of Drug Hypersensitivity from Dapsone
Authors: Thungthienthong Metus , Tongsengkee Nonthanat , Intapiboon Porntip
Published: April 2024

Nowadays, dapsone is more commonly used in some dermatologic and inflammatory conditions other than leprosy. Even though it has excellent therapeutic efficacy, its side effects are of common concern. Although immune mediated drug hypersensitivity is less common, it can be fatal. Sulfone syndrome is a unique presentation that occurs in dapsone hypersensitivity syndrome (DHR). Here, we report on a 22-year-old female who was prescribed one month of dapsone for dermatitis. She developed a generalized maculopapular rash and low-grade fever and observed that her sclera had a yellowish discoloration. This case report demonstrates a unique character of delay-type drug hypersensitivity from dapsone, with the aim of increasing physician awareness when prescribing dapsone.
JOURNALING THERAPY DALAM MENGATASI STRES GURU BIMBINGAN DAN KONSELING SMK DI KABUPATEN BOGOR
Authors: Suryaman Neng Triyaningsih , Wahjuningtijas Rindang , Wulandari Wenny
Published: April 2024

The Guidance and Counseling Teacher profession not only plays a role in helping students' problems and achieving their developmental tasks through guidance and counseling services, but also has other workloads as an educator in schools. Vocational high school counseling guidance teachers, especially in the Bogor Regency Area, are still found to experience collisions in dealing with student behavior that leads to stress. The purpose of this study is to help vocational high school counseling guidance teachers in Bogor Regency to express thoughts and feelings in Journaling Therapy activities to overcome feelings and complaints about stress, both those that arise due to work pressure in carrying out the profession as a teacher, as well as personal problems. With this, researchers conducted a study to prove how Journaling Therapy in overcoming stress in vocational high school counseling guidance teachers in Bogor Regency. This research was conducted using a descriptive qualitative approach. The results of this study found that vocational high school counseling guidance teachers in Bogor Regency experienced a state of stress and difficulty expressing their feelings.
DINAMIKA SUPERVISI DALAM MANAJEMEN BIMBINGAN DAN KONSELING SEKOLAH
Authors: Muliadi Hasibuan Marsal Yunas , Zulhadi Roiz , Dasril Dasril
Published: April 2024

The aim of this research is to describe the dynamics of implementing guidance and counseling supervision management. The research method employed is literature review. Content analysis is used as the data analysis method. The research findings reveal that the implementation of guidance and counseling supervision experiences various dynamics such as mismatched qualifications of supervisors, inconsistency in conducting supervision, and lack of motivation and support in its implementation.
Geografi Informasi Sistem Peternakan Burung di Jabodetabek Menggunakan Metode SLR
Authors: Himawan Imam , Suwela Nandang , Sihombing Redo Abeputra , Triyadi Triyadi , Fauzi Achmad
Published: April 2024

Perkembangan informasi mengenai penangkaran burung di Jabodetabek sangatlah minim, peneliti melihat kesempatan untuk mengelola data yang akan dijadikan sistem informasi penangkaran, kajian data mengadopsi dari komunitas APBN (Asosiasi Penangkaran Burung Nusantara). Observasi di lapangan, jenis burung Murai Batu (Copsyhus malabaricus) merupakan jenis dengan tingkat penangkapan tertinggi dari alam terbesar (sekitar 600-an ekor/bulan) karena telah menjadi komoditas perdagangan jenis satwa liar antar provinsi [1].  Metode yang digunakan dalam penelitian ini adalah SLR (Systematic Literatur Review) dengan data yang diperoleh melalui literature relevan dari tahun 2017 hingga 2022. Terdapat 3 Research Question (RQ), tujuanya agar informasi peternak dapat termonitoring persebaranya di Jabodetabek [2]. Serta burung endemic Indoensia dapat terselamatkan dari kepunahan, semakin banyak peternak di Indonesia maka semakin banyak kicau mania yang tersebar, hingga melestarikan fauna. Dengan menggunakan metode SLR, artikel jurnal direview dan teridentifikasi secara sistematis dengan langkah atau prosedur yang telah ditentukan dapat diikuti dalam setiap proses. Hasil penelitian ini menunjukkan bahwa metode yang digunakan dalam pengembangan sistem informasi geografis  tercapai dengan hasil titik peletakan peta digital [3].
The technical efficiency of chrysanthemum flower farming: A stochastic frontier analysis
Authors: Khoiriyah Nikmatul , Susilowati Dwi , Mintyastuti Dyah Sri , Ali Roihan Muhammad , Forgenie David
Published: April 2024

Over the years, improvements in standard of living and well-being have resulted in an increase in the demand for chrysanthemums, however, the recent COVID-19 pandemic has resulted in a fall in demand. As a result, this study investigates the technical efficiency of chrysanthemum farming and its major determinants. The study was conducted in Bumiaji Village, Bumiaji District, Batu, East Java, Indonesia between January and September 2022. Data was collected via interviews with chrysanthemum farmers using a questionnaire. A total of 35 chrysanthemum farms were selected using random sampling technique. The data was then analyzed using the stochastic frontier method combined with Maximum Likelihood Estimation (MLE). The results reveal that the efficiency of chrysanthemum farming is dominated by 0.91 to 0.93. (65.71 percent). Since technical efficiency is close to one, most chrysanthemum farmers are close to achieving maximum efficiency. The technical efficiency of chrysanthemum blooms was influenced by land area, inorganic fertilizers, organic fertilizers, and pesticides, but not by seeds or labor. The land area negatively impacts technical efficiency, implying that increasing land size decreases technological efficacy of chrysanthemum farming. Inorganic fertilizers, organic fertilizers, and pharmaceuticals have a positive effect or contribute to an increase in inorganic fertilizers, organic fertilizers, and pesticides. In terms of technical efficacy, chrysanthemum cultivation is close to its zenith. It is not necessary to exert effort to reach this ideal land, but inorganic fertilizers, organic fertilizers, and pesticides can assist.
Analysis of strategic programs in planning and developing cocoa agribusiness in Bantaeng Regency
Authors: Arsyad Muhammad , Jamil Muh Hatta , Andi Nuddin  , Madung Nurfaaidah , Amran Arman , Rio Akbar Rahmatullah
Published: April 2024

The fluctuation of production levels, low innovation adoption rates, and low cocoa prices at the farm level are important problems in cocoa agribusiness that cannot be allowed to prolong, especially in production centers such as Bantaeng Regency, South Sulawesi Province. The purpose of this research is to provides strategic program recommendations as a reference for policymakers in designing cocoa agribusiness planning and development. This research used Interpretative Structural Modeling (ISM) analysis to be able to formulate a complex policy structure based on elements and formulate a hierarchy of relationships between elements. The results show that there are five key programs in planning and developing cocoa agribusiness in Bantaeng Regency, namely effectiveness of extension in the field, capacity building of extension workers, the establishment of farming partnerships with companies, the establishment of specialized cocoa development team, and guarantee of price stability. These key programs need to be assisted by supporting programs such as institutional development programs, effective coordination between institutions, effective technology transfer to farmers, provision of organic technology, providing rewards for farmers, providing access to capital, strengthening digital marketing, and improving cocoa quality through fermentation. Based on the interpretation of this research, stakeholders need to have an understanding of the priorities and synergy between programs to ensure the development of cocoa agribusiness that is right on target and in accordance with the needs and conditions currently faced.
Kreacja struktur czasowych w narracjach graficznych na przykładzie Sandmana Neila Gaimana
Authors: Sadowska-Dobrowolska Katarzyna
Published: April 2024

Czas jako element strukturalny narracji jest rozbudowaną kategorią, na którą składa się: czas fabularny (czas narracji i następstwo zdarzeń), układ zdarzeń oraz tempo akcji. W narracjach graficznych temporalny wymiar fabuły kreowany jest nie tylko werbalnie: do kotwiczenia temporalności w poszczególnych kadrach wykorzystywana jest również warstwa ikoniczna. Prezentowany artykuł poświęcony jest opisowi sposobów kreacji struktur czasowych w narracjach graficznych oraz kotwiczenia ram czasowych w poszczególnych panelach i ich sekwencjach. Celem badań była próba stworzenia charakterystyki cech temporalnych wyrażanych najczęściej ikonicznie i/lub werbalnie. W badaniu amerykańskiej powieści graficznej The Sandman Neila Gaimana wykorzystano zarówno metody opisu przekazów werbalnych, tj. analizę składnikową i formalno-semantyczną, jak i jakościową analizę semiotyczną, typową dla opisu komunikatów multimodalnych. Przeprowadzone analizy wykazały istnienie regularności w sposobie wyrażania temporalności. Wskaźniki werbalne czasu dominują w przypadku kreowania linearnego schematu fabularnego i następstwa zdarzeń (retrospekcji i antycypacji). Werbalnych objaśnień warstwy ikonicznej obligatoryjnie wymaga również parataktyczny układ zdarzeń. Ikoniczna kreacja temporalnego wymiaru fabuły dominuje natomiast w przypadku budowania tempa akcji i sygnalizowania jego zmian oraz w tworzeniu układu symultanicznego.Ponadto warstwa graficzna odpowiada za wizualne kotwiczenie w poszczególnych kadrach czasowych ram fabuły.
ECONOMY, CRIME AND WRONG IN A NEOLIBERAL ERA
Authors: Carrier James G.
Published: April 2024

Corporate scandals since the 1990s have made it clear that economic wrongdoing is more common in Western societies than might be expected. This volume examines the relationship between such wrong-doing and the neoliberal orientations, policies, and practices that have been influential since around 1980, considering whether neoliberalism has affected the likelihood that people and firms will act in ways that many people would consider wrong. It furthermore asks whether ideas of economic right and wrong have become so fragmented and localized that collective judgement has become almost impossible.
Liminality in academic middle management
Authors: Davis-Salazar Karla L.
Published: April 2024

This article explores the complex academic-administrative role of the associate dean in US higher education administration. Previous research in Australia, UK and USA indicates that these academic middle managers experience significant conflict and ambiguity due to their roles and responsibilities as faculty members and administrators. Victor Turner's concept of liminality provides insight into the challenges of academic middle management at this administrative level. Analysing qualitative data collected through semi-structured interviews with associate deans at US research-intensive universities, I find that associate deans experience changes in perspective and relationships that foreground contradictions of meaning and highlight their paradoxical social status. I argue that, as part of a process of transition from faculty to administrator, the associate deanship is essential to the social construction of the university.
“Old” and new Hungarian graves on the left bank of the Dniester
Authors:   Leader researcher of the Scientific Research Laboratory “Archaeology” of the Pridnestrovian State University named after T.G. Shevchenko Pridnesrovie, Tiraspol’, Telnov Nikolay P. , Turk Attila ,   Pázmány Péter Catholic University (Budapest, Hungary), Razumov Sergey N. ,   Senior researcher of the Scientific Research Laboratory “Archaeology” of the Pridnestrovian State University named after T.G. Shevchenko / Pridnesrovie, Tiraspol’, Sinika Vitalij S. ,   Head of the Scientific Research Laboratory “Archaeology” of the Pridnestrovian State University named after T.G. Shevchenko Pridnesrovie, Tiraspol’
Published: April 2024

The article analyzes the materials obtained during the study of five Hungarian burials on the left bank of the Lower Dniester. Description of the of the barrow and the grave: Burial near the Butora village, which was sunk into an Early Bronze Age mound and contained a horse’s humerus and fragments of gold foil, was studied in 1978; it was previously published with erroneous cultural-chronological attribution or as uncertain. Two more graves were discovered in 1992 in Early Bronze Age mounds near the town of Slobodzeya. Until recently, archival documentation was considered lost, and anthropological materials and grave goods were not identified. А fragment of an iron steel was found in one of the burials. Bone plates for a bow, iron arrowheads, two iron knives (a long combat one and a short household one) were found in another burial. A Hungarian grave sunk in a Scythian mound was studied near Glinoe village, Slobodzeya district, in 2022, in the kurgan group “Sever”. A fire flint, an iron arrowhead, an awl and a knife, as well as gold foil and a horse’s humerus were found in the grave. A burial containing the humerus of small cattle and an iron arrowhead was excavated in 2023 in the Early Bronze Age mound situated at the “Kulak” cemetery near the Korotnoe village. Grave from the Butory cemetery, one of the burials near the town of Slobodzeya, as well as graves in the “Sever” group and from the “Kulak” cemetery were radiocarbon dated. Burial dating: Analogies to grave goods, as well as seven radiocarbon dates obtained in the Poznan, Kiev and Debrecen laboratories, allow us to date graves to the second half of the 9th – the first half of the 10th century. Final remarks: These burials, together with the Hungarian graves previously discovered in the North-Western Black Sea region, are archaeological sites left by the Hungarians east of the Carpathians immediately before finding their homeland.
Middle Course of Seversky Donets in the 17th–18th Centuries. Locals’ Tangible Culture
Authors:   Donetsk Republican Museum of Local Lore (Doneck, Russian Federation), Kravchenko Eduard E.
Published: April 2024

In the 17th century the development of the steppe outskirts of the Russian state witnessed settling in the middle course of the Seversky Donets River. The territory was developed by Russian military settlers and settlers from the Dnieper region – Cherkasses. Their number was increasing since the second half of the 17th century. During this period, a number of fortified settlements were built in the region, the most important of which were connected by the Thora defensive line. Later the area received not fortified settlements. The southernmost point of this region was the Bakhmut fortress founded in 1701. The development of the territories south of this fortress began in the second half of the century. It marks the beginning of the new stage in the development of the Russian people of the steppes of the Northern Azov region. Archaeological research of these monuments located in the north of Donbass was conducted at the turn of 20th–21st centuries. The explorations found undisturbed remains of the Torsa defensive line of the 17th century, and revealed a number of unfortified settlements. Archaeological excavations were carried out at key sites. The key sites include Sviatogorsk monastery as one of the earliest settlements in this area. More basic research was carried out at Kazachya Prystan (Raigorodok), Tor (Slavyansk), and a settlement located in the Yavor tract. These works helped obtain a large amount of archaeological material that describes different aspects of economic and cultural life of the people who were developing the Russian border steppes in the 17th–18th centuries. These people are direct ancestors of the current inhabitants of the settlements located in the north of the Donetsk region.
ANALYSIS OF THE POSSIBILITY OF INFORMATION TECHNOLOGIES INTEGRATION INTO THE PROCESS OF CORPORATE TRAINING FOR EMPLOYEES OF MILK PROCESSING ENTERPRISES IN UKRAINE
Authors: SENYK Yurii
Published: April 2024

Nowadays, the use of the latest IT technologies for educational purposes at milk processing enterprises is at a low level. That is why, to study the motives that have a significant impact on the intention to use technology in the process of training specialists of various directions and levels, a study was conducted based on one of the milk processing enterprises of the western region.
The methodology of the analysis was based on the concept of TAM, 32 specialists of various services of the milk processing enterprise in the western region of Ukraine, who are engaged in personnel training in addition to the job, took part in the survey. To obtain primary data, a questionnaire was developed based on literature data of similar studies.
The analysis includes testing for the adequacy of the data and the research model – the relationship between the six research elements. The obtained data indicate a relatively low level of confidence in the effectiveness of using computer technologies during corporate training, and the indicator of internal motivation or personal intentions (PI) is the lowest of all values - 3.44. Thus, it can be assumed that such data are related to certain internal beliefs of each member of the group of interviewed employees of the enterprise. To test this assumption, multiple-cause modeling (MIMIC) was used to assess whether there are correlations in respondents' intrinsic motivation with their age and level of education. The calculated coefficients will make it possible to assess the presence of a direct influence of these two variables on the level of employees’ motivation, and their value can be interpreted as the possible presence of an additional factor i.e. the presence of a degree or its absence, as well as the difference in the age of the respondents.
The obtained results of the statistical analysis established a correlation between motivation and higher education among employees, indicating that the presence of a specialist or master's degree increases the probability of using computer technologies in the learning process. This is probably related to the use of electronic learning technologies in the programs of their training at the university. Thus, it is obvious that in order to increase the use of IT technologies in the process of corporate training, it is necessary to form among the company's employees computer literacy skills necessary for life in modern society and to develop the ability to use the latest technologies for searching, analyzing, using and transmitting information.
PENGARUH KUALITAS PELAYANAN TERHADAP TINGKAT KEPUASAN KONSUMEN PENGGUNA LAYANAN JASA ANTAR MAKANAN (GOFOOD) DI KOTA CIREBON
Authors: Febianti Yopi Nisa , Welly Welly
Published: April 2024

One of the businesses developed by Gojek is Go-food. Go-food is a service feature provided by Gojek which provides food delivery services. Go-food services provide convenience in terms of mobility and the food ordering process. Apart from that, the simple payment system also makes Go-food a favorite choice among the public. This research aims to determine the effect of service quality on the level of satisfaction of users of food delivery services (Go-Food) in Cirebon City. Quality in this context includes aspects such as delivery speed, order accuracy, food quality, and customer service availability. This research uses a survey method by distributing questionnaires to Go-Food users in Cirebon City. The population of this research is people in the Cirebon City area who have used Go-Food services) with an unknown population size. The sampling technique uses purposive sampling. Using questionnaire data collection techniques. Test analysis uses multiple linear regression tests. The results of the analysis show that service quality has a significant positive effect on the level of satisfaction of Go-Food service users in Cirebon City. This means that the higher the quality of service provided by the company, the higher the satisfaction that consumers will feel.
ANALISIS PEMBIAYAAN MEKAAR PLUS SYARIAH PT. PERMODALAN NASIONAL MADANI MEKAAR CABANG RUPIT MUSI RAWAS UTARA
Authors: Hamidah Nur , Saleh Muhammad
Published: April 2024

Mekaar syariah financing is financing to meet the need for increased production both quantitatively and qualitatively. The purpose of this research is to determine the analysis of Mekaar reguler Sharia financing at PT. Madani National Capital (PNM) Mekaar North Rupit Musi Rawas Branch, supporting and inhibiting factors. The method used is qualitative with data collection techniques using interviews, observation, and documentation. The data analysis techniques used are data reduction, data display and verification. Test the validity of the data using Triangulation. Research respondents consisted of: area heads, branch heads, deputy branch heads, FAO, accounts officers. The research results found that PT. PNM Mekaar Syariah North Rupit Musi Rawas Branch conducted a financing analysis in 2 stages. The first analysis is analysis of the financing process, which consists of 4 stages in the form of preparation, identification, analysis and verification, finally monitoring. The second analysis is analysis of customer needs, in this case PNM carries out analysis in the form of Working Capital Turn Over (WCTO), Project Cost, and based on the Cost Budget Plan (RAB).
PENGARUH PERCEIVED ORGANIZATIONAL SUPPORT, MOTIVASI INTRINSIK, DAN PERSON JOB-FIT TERHADAP JOB SATISFACTION
Authors: Roji Fahrul , Kurniawan Ignatius Soni
Published: April 2024

A company's performance is mostly influenced by its human resources' capacity to adapt, develop, and contribute fully to the business. The primary element to gaining a competitive advantage is to implement effective and innovative HR management techniques. Companies must assure employee work satisfaction because it has a direct impact on productivity, retention, and the organizational image. This study aims to analyse the effect of perceived organisational support, intrinsic motivation, and person-job fit on job satisfaction among employees of PT Mitra Tirta Buwana Tbk Yogyakarta. This research is quantitative and uses primary data obtained from filling out questionnaires taken with the census technique on respondents. Data collection using direct surveys was processed using multiple linear regression analysis, preceded by classical assumption tests utilising the SPSS software application. The results stated that perceived organisation support has a significant positive effect on job satisfaction, intrinsic motivation has a significant positive effect on job satisfaction, and person-job fit has a significant positive effect on job satisfaction. The implication is that companies can increase antecedents to strengthen their employees' job satisfaction
DAMPAK GAYA KEPEMIMPINAN BERORIENTASI PRESTASI DAN IKLIM ORGANISASI TERHADAP KOMITMEN AFEKTIF DAAITV MELALUI KEPUASAN KERJA
Authors: Dina Dina , Ginting Ginta , Ariyani Ida
Published: April 2024

This study aims to ascertain the impact of independent factors like achievement-oriented leadership style and organizational climate. Affective commitment is a dependent variable, whereas job satisfaction is an intervening variable. The primary source of data for this quantitative study was an instantaneous Likert scale questionnaire delivered to each research participant. Employees of PT. X Jakarta and Medan make up the research population. A sample of 136 participants was selected using non-probability sampling techniques in conjunction with the purposive sampling approach. This study makes use of multivariate data analysis methods with the statistical model SEM-PLS. The results of the analysis show that there is a positive and significant effect of achievement-oriented leadership style on job satisfaction, affective commitment and affective commitment through job satisfaction. There is also a positive and significant effect of organizational climate on job satisfaction, affective commitment and affective commitment through job satisfaction. And there is a positive and significant effect of job satisfaction on affective commitment. These results provide managerial implications regarding how to increase employee affective commitment by paying attention to the achievement-oriented leadership style of the leaders and the organizational climate formed and increasing employee job satisfaction.
PENGARUH KURIKULUM MERDEKA BELAJAR TERHADAP HASIL BELAJAR EKONOMI DI MAN 1 SINTANG
Authors: Kamarullah Heri , Marganingsih Anna , Thoharudin Munawar
Published: April 2024

The Independent Learning Curriculum is a new innovation in improving the quality of learning, giving students the opportunity to choose learning according to their interests and needs. This research investigates the impact of the Independent Learning Curriculum on economic learning outcomes at Madrasah Aliyah Negeri 1 Sintang during the 2022/2023 academic year, by considering learning motivation as a moderating factor. Data from 280 students in grades XI A to XI H were collected through questionnaires and documentation, then analyzed using path analysis. The results of the analysis show that there is a positive and significant influence of the Independent Learning Curriculum on economic learning outcomes (correlation coefficient 0.160, t value 1.822, significance 0.035), as well as a positive and significant influence on learning motivation (correlation coefficient 0.382, t value 5.908, significance 0.000). Learning motivation was also proven to have a significant effect on economic learning outcomes (correlation coefficient 0.154, t value 2.242, significance 0.016). Furthermore, the implementation of the Independent Learning Curriculum indirectly influences economic learning outcomes through the mediation of learning motivation (correlation coefficient 0.152, t value 2.042, significance 0.022).
CREATING A SUSTAINABLE DIGITAL BUSINESS ECOSYSTEM: CHALLENGES AND OPPORTUNITIES FOR GLOBAL ECONOMIC DEVELOPMENT
Authors: Arifin Ahmad
Published: April 2024

This research aims to analyze the challenges and opportunities in creating a sustainable digital business ecosystem to support inclusive global economic growth. The research method used includes collecting and analyzing various documents such as research reports, academic publications, government policies, and industry documents related to digital business ecosystems, sustainability, and global economic development. The results show that the integration between the concepts of digital business ecosystems and sustainability has a crucial role in creating a sustainable business environment. Key factors such as digital inclusion, sustainable innovation and multi-stakeholder partnerships were identified as important elements in achieving this goal. The implications of this research highlight the need for collaborative action between governments, companies, and non-governmental organizations in designing policies and business practices that support sustainable economic growth. Building a comprehensive, forward-thinking, and environmentally friendly digital business network is essential for long-term economic development that positively impacts society. Stakeholders can achieve long-term improvements that benefit future generations by prioritizing economic, social, and environmental sustainability. This research aims to build a durable digital business environment for the betterment of the world economy through its contribution to academic literature and business practice.
Pertanggungjawaban Notaris Terhadap Pemalsuan Tanda Tangan Penghadap Atas Akta Kuasa Jual Beli
Authors: Raihan Iqbal , Hertanto Hasril
Published: April 2024

Jabatan Notaris adalah jabatan publik karena notaris diangkat dan diberhentikan oleh pemerintah. Notaris menjalankan tugas negara dan akta yang merupakan dokumen negara. Jabatan Notaris sangat rawan untuk terkena jeratan hukum, bukan hanya karena faktor internal yang berasal dari dalam diri Notaris, seperti kecerobohan, tidak mematuhi prosedur, tidak menjalankan etika profesi, melainkan juga faktor eksternal seperti moral masyarakat dimana Notaris dihadapkan dengan dokumen palsu, sedangkan dokumen tersebut mengandung konsekuensi hukum bagi pemiliknya. rumusan masalah dalam penelitian ini Bagaimanakah pertanggungjawaban Notaris yang telah melakukan tindak pidana pemalsuan tanda tangan pada pembuatan akta kuasa menjual? Dan Bagaimanakah pemberian sanksi kode etik bagi notaris yang telah dijatuhi hukuman pidana? Simpulan yang didapat dari penelitian ini adalah bahwa perbuatan Notaris tersebut terbukti dan bertanggung jawab atas perbuatannya melakukan pemalsuan tanda tangan dalam Akta Kuasa Menjual, dan sudah sepatutnya Notaris tersebut dikenakan sanksi kode etik Notaris mengenai pemberhentian dengan tidak hormat dikarenakan telah memenuhi unsur yang terkandung pada pasal 13 UUJN sebagaimana jika Notaris dihukum dengan ancaman pidana 5 (lima) tahun dapat langsung dilakukan pemberhentian dengan tidak hormat oleh Menteri.
Assumptions, Resources, and Inputs to Case Management: Implications for California’s Regional Center System
Authors:   , Flint Jonathan
Published: April 2024

This project adds to knowledge of case management assumptions, resources, and inputs for California’s Regional Center system by surveying members of the Service Access and Equity working group, formed by the Department of Developmental Services (DDS). It recommends development of a logic model to evaluate case management activities because their intended societal impacts are difficult to directly measure. Additionally, it adds to the debate on health equity and racial disparities in Medicaid long-term services and supports (LTSS). In 1969, passage of the Lanterman Developmental Disabilities Services Act (The Lanterman Act) led to the first and still only entitlement to community-based services that is granted to people with developmental and intellectual disabilities (I/DD) by a state. Twenty-one private, nonprofit Regional Centers have exclusive rights to provide case management and to purchase community- based services for eligible consumers within their catchment area. By contracting with DDS, Regional Centers receive reimbursement for case management operations, pass-through rates to purchase community-based services, and administer various grants, projects, and funds. This project contributes to understanding whether and how knowledge gaps in Regional Center case management affect expenditures of home- and community-based services (HCBS). In addition, Vogel et al. (2019) lay out systemic LTSS and demographic challenges in California: a higher percentage of people require services and have autism; a growing unpaid caregiver and adult consumer population aging-in-place at home; a struggle with rising labor costs to recruit and retain qualified personnel, high cost of housing for community living, and non-compliance with Medicaid HCBS regulation that may restrict federal funding. Surveying working group members’ knowledge of case management in home- and community-based services improves understanding of the disparities in service access for racial and non-English speaking consumers.
New coronavirus infection of professional origin in medical workers of the Republic of Tatarstan
Authors:   Kazan State Medical University, YAKUPOVA F. M. ,   Kazan (Volga Region) Federal University, GARIPOVA R. V. ,   Kazan State Medical University,   Kazan (Volga Region) Federal University,   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, SAFINA K. R. ,   Republic Center of Occupational Pathology, GISMIEVA A. I. ,   Kazan State Medical University, NURUTDINOVA A. R. ,   Kazan State Medical University, ALEKSEEVA E. I. ,   Kazan State Medical University
Published: April 2024

The purpose — to conduct a clinical, epidemiological and expert analysis of occupational cases of new coronavirus infection (NCVI) in medical workers (MW) of the Republic of Tatarstan. Material and methods. On the basis of the Republic Center for Occupational Pathology (RCPP), a retrospective analysis of the medical documentation was conducted (n = 47, 40 fatal cases, 7 complicated COVID-19 without fatal outcome, from April 2020 to August 2023). Results. The study group of MW with NCVI (n = 47) consisted mainly of women — 30 (63.8%), median age 58 (50; 64) years. Doctors of various specialties (20/42.5%) and nurses – 16 (34%) prevailed in the structure of positions of MW with NCVI. According to the vaccination history, only 12 (25.5%) MW were vaccinated. Comorbid is eases were detected in 43 (91.5%) patients. At the time of hospitalization, the leading clinical syndromes were infectious-toxic and respiratory. The diagnosis was verified in 46 (97.9%) MW by PCR when SARS-CoV2 RNA was detected in an oropharyngeal smear. Against the background of the disease severity, 40 (85.1%) MW had a fatal outcome, 7 (14.9%) had a complicated course with outcome in pneumofibrosis or sensor-neural hearing loss. Upon examination of the NCVI cases connection with the occupation, 40 (85.1%) were diagnosed with occupational disease (PD). according to Article 8 of Federal Law No. 125-FZ of 07/24/1998, various types of insurance and a one-time insurance were provided to medical workers and their family members (in case of the MW death), if the connection of the NCVI with the occupation was established. Conclusion. Connection of the NCVI with the occupation was established in 40 (85.1%) out of 47 medical workers (33 cases with a fatal outcome; 7 cases of a complicated COVID-19). The development of complicated and lethal forms of COVID-19 was registered in medical workers aged over 45 years old with unfavorable premorbid, including in vaccinated individuals with multiple comorbidity. Pre-contact immunoprophylaxis is still in demand in middle and older age groups, and in occupational risk groups. At the present stage, timely specific diagnosis of NCVI and the appointment of effective etiotropic and proactive pathogenetic therapy remain relevant.
Densitometric assessment of bone mineral density in young patients with Hodgkin’s lymphoma
Authors:   Federal Medical Biophysical Center named after A.I. Burnasyan, NAGIEVA A. R. , PRASKURNICHIY E. A. ,   Federal Medical Biophysical Center named after A.I. Burnasyan,   N.I. Pirogov Russian National Research Medical University, KITAEVA YU. S. ,   Federal Medical Biophysical Center named after A.I. Burnasyan,   Ural State Medical University
Published: April 2024

Hodgkin’s lymphoma is more often diagnosed in young patients. One of the late complications of pathogenetic therapy of Hodgkin’s lymphoma is osteopenia/osteoporosis and the increased risk of low-energy fractures. Conducting densitometry in young patients in order to assess the bone tissue condition is advisable, but its clinical assessment remains difficult. At the same time, early diagnosis and prevention of bone mineral density decrease in patients with Hodgkin’s lymphoma who received antitumor therapy are very relevant. The purpose — to study the features of densitometric indicators for the verification of osteopenia / osteoporosis in young patients with Hodgkin’s lymphoma. Material and methods. 63 people were included in the study, 33 of them were patients with Hodgkin’s lymphoma who received pathogenetic therapy, and 30 people the control group — healthy volunteers. Bone mineral density was measured in all patients using the HOLOGIC (Hologic Inc., Bedford) in the lumbar spine (L1–L4) and in the hip area (the total area of the hip and hip neck). Criteria such as minimum bone mineral density, T-criteria and Z-criteria for young patients with Hodgkin’s lymphoma were determined. Results. In the group of patients with Hodgkin’s lymphoma, a decrease in bone mineral density is significantly more often recorded in all measurement areas, as well as the Z-criterion in the lumbar spine. Regretfully, in young patients the T-criterion can only be used given a more intensive mineralization of bone tissue than in older people and the presence of additional risk factors for osteoporosis (PCTs, glucocorticosteroids, decreased androgenic and fertile function). In patients with HL who received pathogenetic therapy, a decrease in the T-criterion to osteopenia is more often observed in the proximal femur. Conclusion. In many cases, modern capabilities for osteoporosis diagnostic allow correcting mineral metabolism in bone tissue and preventing the development of complications in young patients with Hodgkin’s lymphoma.
Autoimmune postinfarction syndrome
Authors:   Saratov State Medical University, BLINOVA V. V. , BOGDANOVA T. M. ,   Saratov State Medical University, SEMENOVA V. A. ,   Saratov State Medical University, SERGEEVA E. O. ,   Saratov State Medical University, ZANKIN M. A. ,   Saratov State Medical University, SINKEEV M. S. ,   Saratov State Medical University
Published: April 2024

The purpose — to present a clinical case of diagnosing the autoimmune postinfarction syndrome (Dressler syndrome). Material and methods. The medical documentation of a patient with myocardial infarction complicated by Dressler syndrome was analyzed. Results. The clinical case presents a patient with acute extensive anterior myocardial infarction who sought medical help on the 2nd day of the disease, which may have caused the autoimmune postinfarction syndrome on the 11th day of the disease (fibrinous exudative pericarditis, focal pneumonia, eosinophilia and laboratory signs of inflammation). The patient’s low adherence to the treatment during hospitalization contributed to the subsequent development of coronavirus infection. Conclusion. The publication is of interest to cardiologists, doctors of functional and radiation diagnostics. The diagnosis of Dressler syndrome is based mainly on the results of laboratory and instrumental research methods as the onset and course of Dressler syndrome most often has a poor clinical picture.
Herpetic infections and inflammatory bowel diseases
Authors:   Kazan State Medical University, FATKULLINA G. R. , GABDRAHMANOVA CH. SH. ,   Prof. A.F. Agafonov Republican Clinical Infectious Diseases Hospital, DZAMUKOV S. R. ,   Kazan State Medical University, DZAMUKOVA M. I. ,   Kazan State Medical University
Published: April 2024

It is well known that herpes viruses are pantropic; therefore, herpes infections have a varied clinical picture. There are studies establishing a connection between the course of inflammatory bowel diseases, the effectiveness of their treatment, and the detection of herpesvirus DNA in the mucous membrane of the colon. The article examines a case of reactivation of a chronic herpetic infection with a predominant clinical picture of colitis against the background of immunosuppression after successive coronavirus SARS-Cov-2 and rotavirus infections. Against the background of antiviral therapy, clinical improvement was noted, laboratory parameters and histological analyzes were normalized.
Meningitis associated with B19 parvovirus in a child
Authors:   Kazan State Medical University, KHALIULLINA S. V. , DOLOVSKOVA D. E. ,   Republic Clinical Infectious Diseases Hospital named after Prof. A.F. Agafonov, ALATYREV E. YU. ,   Republic Clinical Infectious Diseases Hospital named after Prof. A.F. Agafonov, EMELYANOVA P. N. ,   Republic Clinical Infectious Diseases Hospital named after Prof. A.F. Agafonov
Published: April 2024

Damage to the nervous system is not typical for parvovirus infection, however, reports of such observations are becoming more and more widespread. We describe a case of meningitis associated with B19 parvovirus in an eight-month-old child without hematological diseases and immunodeficiency, which occurred simultaneously with staphylococcal enterocolitis. The diagnosis was made based on the detection of parvovirus B19 DNA in the cerebrospinal fluid and antibodies (Ig M) in the blood. Clinical symptoms were sparse, and the classic meningitis syndrome complex was not observed. There were also no typical manifestations of erythema infectiosum. Treatment included the administration of intravenous immunoglobulin and a short course of glucocorticosteroids. Recovery occurred 20 days after the disease onset. Observation for a month after discharge from the hospital did not show significant deviations in the child’s health.
Predictors of unfavorable prognosis of atypical hemolytic-uremic syndrome in children
Authors:   Russian University of Medicine, EMIROVA KH. M. ,   St. Vladimir Children’s Clinical Hospital, ORLOVA O. M. ,   Russian University of Medicine,   St. Vladimir Children’s Clinical Hospital, VAKHITOV V. K. ,   Kazan State Medical University, CHICHUGA E. M. ,   Voronezh State Medical University named after N. N. Burdenko, ZAITSEVA O. V. ,   Russian University of Medicine, MUZUROV A. L. ,   Russian Medical Academy for Continuing Professional Education, MAKAROVA T. P. ,   Kazan State Medical University, AVDONIN P. V. ,   Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, AVDONIN P. P. ,   Koltzov Institute of Developmental Biology of the Russian Academy of Sciences
Published: April 2024

Atypical hemolytic-uremic syndrome (aHUS) is an ultra-rare disease based on the development of complement-mediated thrombotic microangiopathy, which has an unfavorable prognosis in its natural course. The purpose — to determine predictors of unfavorable prognosis of aHUS in children. Material and methods. 70 patients (aged 2.5 months — 16 years) were examined at the debut of aHUS and 54 in the catamnesis (1–6 years). The activity of metalloproteinase ADAMTS13 was determined in all children in the acute period by the FRET method. The peculiarities of the course and outcomes of the disease were analyzed. Results. 62.9% of children had decreased ADAMTS13 activity. ADAMTS13 deficiency (57.2 vs 15.6%) was associated with prolonged thrombocytopenia (p = 0.03), development of anuric acute kidney injury (p = 0.0005), increased risk of anuria (OR 8.4; 95% CI 2.2–32.1) with the need for dialysis (OR 5.25; 95% CI 1.77–15.57). In the catamnesis group, 61.1% of cases had CKD, 53.7% had proteinuria, and 38.9% had arterial hypertension. The development of CKD directly correlated with CNS damage (rpb = 0.32, p = 0.02), duration of anuria (R = 0.74, p = 0.001), thrombocytopenia (R = 0.5, p = 0.0009), duration of dialysis (R = 0.45, p = 0.008) and late start of complement-blocking therapy with eculizumab (rpb = 0.54, p = 0.0004). CКD C2-C5 in the distant catamnesis (3–6 years) developed in children who had thrombocytopenia > 10 days at the debut of aНUS (p = 0.0005), anuria > 7 days (p = 0.03) and needed dialysis > 10 days (р = 0.02). Conclusion. ADAMTS13 activity deficiency is associated with a more severe course of acute аHUS episode, but does not affect the long-term prognosis. The risk of developing CKD is associated with the severity of acute aHUS. To improve the prognosis of renal and overall survival of patients with aHUS, long-term monitoring of the condition and preventive measures aimed at ensuring long-term remission are necessary.
Clinical significance of integral registration of markers of endotoxic immunity and colonization resistance of buccal epitheliocytes in recurrent bronchitis in adolescents
Authors:   Kazan State Medical University, PIKUZA O. I. , ZAKIROVA A. M. ,   Kazan State Medical University, SAMORODNOVA E. A. ,   Kazan State Medical University, FAYZULLINA R. A. ,   Kazan State Medical University, VOLYANYUK E. V. ,   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia
Published: April 2024

Recurrent bronchitis (RB) occupies one of the key places in the structure of nonspecific diseases of the respiratory tract and remains a significant medical and social problem in healthcare. The purpose — to investigate and evaluate the clinical significance of integral registration of markers of endotoxic immunity and colonization resistance of buccal epithelial cells (BE) in RB in adolescents. Material and methods. The study included 117 children (12–17 years old), including 78 with RB — the main group, 29 with acute bronchitis (AB) — the comparison group and 23 conditionally healthy children — the control group. The analysis of anamnestic, clinical, paraclinical data, verification of etiologically significant viruses, registration of artificial colonization of buccal epithelial cells (BE), colonization index (CI), micro-LAL test were carried out. Statistical processing of the results was carried out using the SPSS program. Results. A significant difference in markers of colonization resistance and anti-endotoxin protection was revealed in recurrent inflammation in the respiratory tract in comparison with AB in peers. In RB, the initial degree of Candida albicans adhesion to BE was significantly higher in relation to AB (p = 0.0427) and upon discharge from the hospital did not reach normative values, being significantly different from patients with AB (p = 0.0391). The high index of artificial colonization indicates the activation of allochthonous flora and disruption of the microbiota in the oral cavity, which negatively affects the body reactivity. In patients with RB, the titer of antiglycolipid antibodies significantly decreased and in 75% the values did not return to normal, while in AB they did not differ from the control. High levels of endotoxin were noted in RB compared to AB (p = 0.0317). Such patients were diagnosed with a more severe course of the disease with symptoms of endogenous intoxication and a long hospitalization period. Using the method of correlation analysis, a high direct relationship was established between artificial colonization and endotoxin concentration (r = 0.71). The relationship between these parameters in AB was significantly less pronounced (r = 0.3). The results obtained indicate close integration and mutual modulation of the local oral immunity and antiendotoxin defense. Conclusion. Integral registration of the markers of reactivity of specific anti-endotoxin immunity and colonization resistance reflect the severe inflammatory process in the respiratory tract and predict the risk of a chronic pathological process in the bronchopulmonary system.
Analysis for the Presence of Borax in IRTs and MSMEs Producing Karak in Bulu
Authors: Lucky Lucky Sanjaya , Widyastuti Retno , Hartati Sri
Published: April 2024

Home Industry products and Micro, Small and Medium Enterprises (MSMEs) in the form of traditional foods are widely developed in Sukoharjo Regency. Traditional food karak crackers are one of the products favored by the people of Central Java, especially Sukoharjo Regency. Karak crackers are a food that is much loved by the community because it tastes savory, cheap and can be used for side dishes and snacks. The main ingredient in making karak crackers is poor quality rice or rice groats with added salt and bleng. Bleng is alleged to contain borax, which is harmful when it enters the human digestive system. This study aims to determine the presence of borax contained in karak crackers produced by IRTs and MSMEs in Bulu Subdistrict and to select alternative ingredients to replace bleng (borax). This research was conducted with 2 methods, namely survey and evaluation, in the survey method to determine the sample using stratified purposive sampling with 3 levels. After the karak cracker samples were collected, the presence of borax was tested using turmeric extract. The results obtained stated that all samples from IRTs and MSMEs contained borax.