EFFECT OF SORPTION-DETOXIFYING COMPLEXES ON THE ACCUMULATION OF CADMIUM AND LEAD IN ORGANS AND TISSUES OF WHITE RATS
Authors:   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K. I. Skryabin, Ya. R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow, Russian Federation, Zakharova Lyubov L. , Brichko Natalia A. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K. I. Skryabin, Ya. R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow, Russian Federation, Zhorov Georgy А. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K. I. Skryabin, Ya. R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow, Russian Federation, Obryvin Viktor N. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K. I. Skryabin, Ya. R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow, Russian Federation, Lemiyaseva Svetlana V. ,   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K. I. Skryabin, Ya. R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow, Russian Federation
Published: November 2021

The environmental consequences of technogenic pressure pose a real threat to the health of the population and animals. The main danger to humans is the presence of pollutants of radiation and chemical nature in food. The production of animal products that meet the regulatory requirements, and the ensure of veterinary and sanitary welfare in regions with increased anthropogenic load is impossible without the use of effective methods of reduce the intake and accumulation of pollutants in the organism of animals. Therefore, in areas with a difficult environmental situation, when performing general detoxification, it is necessary to use a wider range of pharmacological agents, including antioxidants, immunomodulators, vitamin and mineral supplements and other biologically active substances that compensate for the negative effects that develop in the body as a result of exposure to harmful ecological factors, contribute to the restoration of health, increase the productivity of farm animals and product quality. In this regard, the combined use of anti-toxic and biologically active substances in the composition of sorption-detoxifying complexes is rational. As a result of testing the effectiveness of seven samples of sorption-detoxifying complex compositions in terms of their effect on the accumulation of Cd and Pb in the body of white rats, it was found that studied formulations reduce their intake to organs and tissues by 1.2-2.9 times, depending on the composition of the detoxifier, both separately and with the presence of heavy metals when combined with radioactive substances in the feed.