bluuebunny/crossref_metadata_2025 huggingface dataset:
On problematic issues of qualification of crimes related to the illegal production and circulation of materials or objects with pornographic images of minors
Authors: Яшков Сергей Александрович
Published: September 2022

В настоящей работе исследуются преступления, предусмотренные ст. 242.1-242.2 УК РФ. Автор анализирует особенности уголовной ответственности за незаконные манипуляции с порнографическим изображением несовершеннолетних, а именно деяния, связанные с изготовлением и оборотом материалов или предметов с такими изображениями. Анализируются объективные и субъективные признаки заявленных составов преступлений с целью определения проблем, которые могут возникнуть при расследовании указанной категории преступлений. Рассматриваются особенности предмета анализируемых преступлений; потерпевших - несовершеннолетних, в том числе малолетних; сложности при определении сущности объективной стороны состава преступления (по некоторым из альтернативных деяний), в том числе при определении момента окончания преступления. Исследуются также проблемы, которые могут возникнуть при доказывании умысла на совершение отдельных преступлений, предусмотренных анализируемыми статьями уголовного закона. Кроме того, в рамках определенного примера анализируется такой факультативный признак субъективной стороны состава преступления, как цель, а именно изготовление порнографических материалов или предметов. В результате автор приходит к выводу, что все возникающие в процессе расследования трудности могут быть преодолены за счет изучения судебно-следственной практики, а также путем обращения к теории уголовного права, посвященной основам квалификации преступлений.

This paper examines the crimes under Art. 242.1-242.2 of the Criminal Code of the Russian Federation. The author analyzes the features of criminal liability for illegal manipulations with the pornographic images of minors, namely, acts related to the production and circulation of materials or objects with such images. The author analyzes the objective and subjective features of the declared corpus delicti in order to identify problems that may arise in the investigation of this category of crimes. The article discusses the features of the subject of the analyzed crimes; victims - minors; difficulties in determining the essence of the objective side of the corpus delicti (for some of the alternative acts), including in determining the moment when the crime ends. The author also explores the problems that may arise when proving intent to commit certain crimes provided for by the analyzed articles of the criminal law. In addition, within the framework of a certain example, the article analyzes such an optional feature of the subjective side of the corpus delicti as a goal, namely the production of pornographic materials or objects. As a result, the author concludes that all the difficulties arising in the process of investigation can be overcome by studying the judicial and investigative practice, as well as by referring to the theory of criminal law, devoted to the basics of qualification of crimes.
Management accounting: monitoring investment indicators as a justification in case of disagreement with the bank
Authors: Остаев Гамлет Яковлевич , Злобина Оксана Олеговна , Хосиев Борис Николаевич
Published: September 2022

В статье рассматриваются вопросы управленческого учета как базы для принятия инвестиционного решения в отношении реальных инвестиций и привлечения кредитных средств. Информация, формирующаяся в системе управленческого учета, а именно в разрезе мониторинга инвестиционных показателей (внутренней и внешней среды), наиболее эффективна как доказательная база при форс-мажорных обстоятельствах, в том числе если банк по каким-либо причинам заморозил счета экономического субъекта. Соответственно, система управленческого учета аккумулирует информацию по различным индикаторам, свидетельствующую о том, что бизнес-проект, под который получены инвестиции, может окупаться и приносить инициаторам проекта дополнительную прибыль. Сделан вывод о том, что методы управленческого учета должны быть эффективны с точки зрения привлечения инвестиций и реализации проекта.

The article examines the issues of management accounting as a basis for making investment decisions in relation to real investments and attracting credit funds. The information generated in the management accounting system, namely in the context of monitoring investment indicators (internal and external environment), is most effective as an evidence base under force majeure circumstances, including if the bank freezes the accounts of an economic entity for some reason. Accordingly, the management accounting system accumulates information on various indicators, indicating that the business project for which investments have been received pays off and can bring additional profit to the project initiators. The article concludes that management accounting methods are effective in terms of attracting investment and project implementation.
ADAPTIVE MULTI-CRITERIA RISK MANAGEMENT SYSTEM
Authors: Фомин Г. П. , Сухорукова И. В. , Грибов А. Ф.
Published: September 2022

В статье рассматривается архитектура построения системы управления рисками на основе фундаментальных аксиом теории управления и принципов теории управления рисками для формирования адаптивной структуры риск-менеджмента. В качестве наиболее эффективного метода моделирования предлагается использовать гибридный с использованием преимуществ как формальных, так и неформальных методов и моделей в построении адаптивной системы управления рисками на предприятиях по принципу снизу-вверх. Для снятия возникающих противоречий индикативных показателей рисков предлагается использовать многокритериальный метод структуризации характеристик в моделях оценки по разным критериям целевых функций - минимизации времени или затрат, максимизации выручки от продаж или прибыли, что и определяет риск неупущенной возможности. Архитектура гибридной адаптивной модели предполагает радикальную схему изменения управленческого поведения, заключающуюся в переходе от обычного регулирования сверху к непосредственному регулированию рисковых факторов в процессе и местах их проявления.

Article discusses the architecture of building a risk management system based on fundamental axioms of management theory and principles of risk management theory to form adaptive structure of risk management. As the most effective modeling method, it is proposed to use a hybrid one, using the advantages of both formal and informal methods and models in building an adaptive risk management system in enterprises on bottom-up basis. To remove the emerging contradictions of indicative risk indicators, it is proposed to use a multi-criteria method of structuring characteristics in evaluation models according to different criteria of objective functions - minimizing time or costs, maximizing sales revenue or profit, which determines the risk of an un-missed opportunity. Architecture of hybrid adaptive model assumes a radical scheme for changing managerial behavior, which consists in transition from conventional regulation from above to direct regulation of risk factors in process and places of their manifestation.
EDUCATION QUALITY MANAGEMENT IN TECHNICAL UNIVERSITIES
Authors: Татаркина Л. А. , Карельская Е. В.
Published: September 2022

Деятельность технических вузов связана с потоком многообразных изменений. Адаптация к инновациям, их внедрение требуют разнообразных преобразований, как правило, новых для вузов и потому носящих инновационный характер. С целью успешного внедрения поставленных инновационных целей необходим способ управления изменениями инновационного характера, то есть любому техническому вузу необходима модель управления инновационной деятельностью технического вуза. Цель статьи показать организационные формы управления техническим вузом, которые будут способствовать повышению уровня знаний обучающегося. Показаны проблемы, стоящие перед техническими вузами, которые должны готовить высокообразованных инженеров для высокотехнологичного производства. Сформирована главная задача профессионального обучения студентов в технических вузах, рекомендовано применение кейс-метода для решения, в процессе обучения, реальных производственных задач, показана роль производственной и преддипломной практики с целью повышения качества образования в технических вузах. Рекомендована балльно-рейтинговая система контроля успеваемости студентов. Для технических вузов предложена схема научно-учебно-инновационного комплекса, структура рынка разработок и модель деятельности высшего технического учебного заведения. Предложено использовать цикл Шухарта-Деминга для построения модели повышения качества образования в вузе. Показано, что управление качеством образования в техническом вузе - это совокупность организационных форм управления.

Activities of technical universities are associated with a stream of diverse changes. Adaptation to innovations, their implementation require a variety of transformations, usually new for universities, and therefore of an innovative nature. In order to successfully implement the set innovation goals, a way to manage innovative changes is needed, that is, any technical university needs a model for managing the innovation activity of a technical university. The purpose of the article is to show the organizational forms of managing a technical university, which will help to increase the level of knowledge of the student. The problems facing technical universities, which must train highly educated engineers for high-tech production, are shown. The main task of vocational training of students in technical universities is formed; industrial and undergraduate practice in order to improve the quality of education in technical universities. A score-rating system for monitoring students' progress is recommended. For technical universities, a scheme of a scientific-educational-innovative complex, a structure of the development market
Сравнительный палиноморфологический анализ подродов Limniris (Tausch) Spach и Scorpiris Spach рода Iris L.(Iridaceae) флоры Армении
Authors: Айрапетян А. М.
Published: September 2022

Pollen morphology of species from the subgenera Limniris (Tausch) Spach and Scorpiris Spach of the genus Iris L. (Iridaceae) of the flora of Armenia was studied using light and scanning electron microscopes. The results revealed that the main differences between these two subgenera are the shape of pollen grains and the type of pollen apertures. Boat-shaped pollen grains with an monosulcate apertures were found in representatives of the subgenus Limniris, while species of the subgenus Scorpiris are characterized by the spheroidal inaperturate pollen grains.
Are C-reactive protein, neutrophil to lymphocyte, platelet to lymphocyte ratios, and mean platelet volume related to the severity of idiopathic carpal tunnel syndrome?
Authors: Altun Yasar
Published: September 2022

Aim: The aim of this study was to investigate the correlation of C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and red cell distribution width (RDW) in patients with idiopathic carpal tunnel syndrome (CTS).
Methods: One hundred patients with CTS and 60 control subjects were included in this study. Medical records and laboratory findings of the participants were analyzed retrospectively between March 2019 and February 2020. Laboratory result values obtained from the members included in the study were examined.
Results: There was a correlation between CRP and the severity of CTS (p<0.01). There was also a positive correlation between CRP and symptom severity scale (p<0.01) and functional status scale (p<0.01). No statistically significant changes were observed in the measurements of blood values other than CRP in the patients.
Conclusions: In this study, a relationship was found between CRP, one of the hematological parameters, and the presence or severity of CTS.
Treatment Outcome in Transplant Ineligible Patients with Multiple Myeloma: A Single center real-life experience
Authors: Uysal Ay , Merter Mustafa , en A
Published: September 2022

Objective: The objective of this study is to assess the choice of first-line and other line options, treatment outcome, and survival effects in transplant-ineligible patients with multiple myeloma (MM) in the novel anti-myeloma agents’ era.
Materials and Methods: Forty-five transplant-ineligible patients with MM were evaluated retrospectively. Patients’ characteristics, disease score, cytogenetic, LDH, treatment lines, treatment protocol, treatment response, and survival status at the last follow-up were examined.
Results: The median age was 71 (range, 60-85) years. Thirty-nine (86,6%) patients were over 65 years old, 32 (71,1%) of them had poor performance scores and 25 (55,6%) of them had comorbidity. The most used induction regimen was bortezomib plus cyclophosphamide plus dexamethasone (n:33;73,3%). The overall response rate was detected in 30 (66,6%) patients in overall induction regimens. The maintenance treatment was applied to 14 (31,1%) patients after induction treatment and lenalidomide plus dexamethasone (Rd) was used for maintenance treatment. Twelve (85,8%) patients are still on maintenance treatment with VGPR or better response. The most used second-line regimen was Rd (n:12; 46,1%) and bortezomib plus lenalidomide plus dexamethasone (n:9;34,6%). The median follow-up period was evaluated as 36 (1-81) months. After the first-line treatment, progression-free survival was found to be 12 (0-64) months. The median overall survival (OS) was 17 (1-81) months. Twelve patients are alive without progression. The median OS was significantly shorter among patients with high LDH at the time of diagnosis than patients with normal LDH [28 (12.06–43.94) months vs 47.21 (21.23–50.77) months, respectively] (p=0.037). The median PFS was not reached in patients with maintenance treatment, in patients without maintenance treatment the median PFS was detected 23 (10-35.9) months (p=0.058).
Conclusion: An induction regimen should be well chosen to ensure a deep and prolonged response, and maintenance treatment should be preferred in suitable patients to maintain response in transplant-ineligible patients.
Blood transcriptional signatures of gallstone pathogenesis in patients with cholelithiasis and choledocholithiasis

Running Title: Blood gene expression gallstone
Authors: Albayrak Do , anlar Oguzhan , Kahya Ey , an Ayten , Doganlar Zeynep
Published: September 2022

Objective
Disease-specific molecular signalling in peripheral blood has the potential to inform on pathophysiological mechanisms of diseases. Here, we aimed to investigate the blood-based gene expression profiles that reflect disease-specific pathogenic mechanisms of gallstones, such as antioxidant defence, heat-shock responses, DNA damage and repair, ABC pump mechanisms, mucin signals, mitochondrial dysfunction and apoptosis in patients with Cholelithiasis (CHL) and Choledocholithiasis (CHDL)
Materials and Methods
The relative fold-change in the mRNA expression levels of 73 genes were analysed using a gallstone-related qRT-PCR array in 10 control individuals, 24 CHL patients and 23 CHDL patients. Serum malondialdehyde levels was determined by thiobarbituric-acid reactive substance assays, and 8-hydroxy-2-deoxyguanosine levels was determined by ELISA assays.
Results
Our results showed that peripheral whole blood gene expression profile strongly reflects tissue specific molecular signalling in gallstone pathogenesis. The present findings of altered gene expressions including antioxidant defence (CuZn-SOD, CAT), heat shock protein (HSP70), DNA repair (MLH1 and RAD18), pro-apoptotic (P53, BAX, Cyt-c and Caspase 3), ABC transporter (ABCB1, ABCC2, and LRP1) and Mucin signals (MUCIN4, MUCIN5AC and MUCIN5B) point out to DNA damages via oxidative stress as well as deteriorating ABC types pump mechanisms and mucin signals in CHL and CHDL patients. Our findings may also suggest that activation of mitophagy activator, DRP1/hFIS1/PINK1 axis induced by oxidative stress and DNA damage may have a role in the pathogenesis of CHL and CHDL.
Conclusions
Our results indicate that a blood-based gene expression signature has promising accuracy for monitorize pathogenesis of disease in CHL patients, CHDL patients and unaffected controls.
Is Health Literacy Clue on the Self-Efficacy of Diabetes Patients?
Authors: Ozcan Gizem , Ozkaraman Ayse
Published: September 2022

Objective: This research was conducted to evaluate the relationship between health literacy level and self-efficacy in patients with diabetes mellitus.
Methods: This cross-sectional study was conducted inpatient and outpatient clinic of internal medicine at the city hospital. The sample of the study consisted of 700 conscious patients diagnosed with diabetes mellitus for at least one year. The data of the study were collected using the Health Literacy Questionnaire-European Union Scale and Type 2 Diabetes Self-Efficacy Scale. Data were analyzed using regression analysis and correlation analyses.
Results: In this study, the level of health literacy general index was sufficient level, and the average of the self-efficacy scale was high. It was observed that health promotion and health service literacy level were effectived in estimating the self-efficacy level of diabetes patients. As the health literacy level of patients for health service and health promotion increased, general self-efficacy level increased.
Conclusion: Health promotion and health service literacy level are effective in estimating the self-efficacy level of diabetes patients.
Comorbidity analysis in obstructive sleep apnea patients
Authors: anl Mustafa
Published: September 2022

Background/Aim: Obstructive sleep apnea (OSA) is a syndrome that causes complete or partial cessation of breathing and as a result of several pathways, hypertension (HT), type 2 diabetes mellitus (DM), and hyperlipidemia (HL) are usually seen as comorbidities. The main problem in the literature is, due to the presence of some confounders, especially body mass index (BMI), it is still not clear that if OSA is an independent risk factor for these comorbidities. This issue may be shown more clearly with BMI and age-matched subjects since they are strongly related to metabolic diseases and HT. Comparison of the ratios of the presence of DM, HL, and hypertension between the age and BMI matched groups is primarily aimed in the present study to see if moderate and severe OSA could be an independent risk factor for these comorbidities.
Methods: Patients admitted with sleep problems were retrospectively scanned from the patient files and cases with polysomnography and routine blood test were included. The body mass indexes, ages, smoking, and alcohol habits of the cases were noted. Two groups were formed based on polysomnography, taking a threshold value of the apnea-hypopnea index (AHI) of 15. Group 1 had cases with AHI <15 (normal and mild apnea patients) and Group 2 had cases with AHI≥15 (moderate/severe apnea patients). Subjects were accepted as having DM, HL, or HT if they are on medication or if their examination and/or laboratory results show the presence of these diseases. The ratios of these diseases within the groups were compared.
Statistical Analysis: Numerical variables were given as mean±standard deviation. Categorical variables were shown as a number. Categorical variables were tested with the Chi-Square test or Fisher’s exact test and an independent T-test was used for two independent groups. Statistical significance was accepted as p<0.05.
Results: There were 22 cases with an AHI<15 and 17 cases with an AHI ≥15, with similar mean BMI and age (p= 0.206, p= 0.054 respectively). The ratio of hypertension was found significantly higher in moderate/severe OSA patients (47% vs 5%; p=0.005). On the other hand, the ratios of DM and HL were found statistically similar (p=0.49, p=1.0 respectively).
Conclusion: This study aimed to show the possible independent role of sleep apnea in metabolic diseases and HT, by creating two groups with similar BMI, age, and cigarette and alcohol habits. The results support moderate/Severe OSA as an independent risk factor for hypertension, while DM and HL are thought to be in close relationship with BMI.
Acute Kidney Injury Following COVID-19 and Risk factors for Progression to Chronic Kidney Disease
Authors: ksel enver , nta derya
Published: September 2022

Background: Acute kidney injury (AKI) is one of the frequent complications of COVID-19 infection. The predictors of progressive kidney disease for patients with COVID-19- associated AKI (COV-AKI) are unclear. In our study, we aimed to demonstrate the risk factors of non-recovery of COV-AKI.
Method: COV-AKI developed in 901 of 3337 patients treated in our hospital for COVID-19 between April 1, 2020 and November 30, 2020. 331 of 901 patients with COV-AKI died at the hospital. Of these patients, 459 patients who met the inclusion criteria were included in the study, while 111 patients were excluded. At 3 months post-AKI, 399 of 459 cases (Group 1) recovered from AKI, and 60 (Group 2) did not.
Results: The median age of the patients included in the study was 68 (59-76), and 44.9% (206) of them were women. Thirty-five of 60 patients in Group 2 developed de novo chronic kidney disease while 25 patients had a history of chronic kidney disease (CKD) and experienced a disease progression. We found that patients with low serum albumin levels (hypoalbuminemia) at admission (P<0.001) were associated with non-recovery of AKI or occurrence of CKD progression, in COV-AKI.
Conclusions: Although the short-term outcomes of COV-AKI are relatively well-known, the long-term outcomes are needed to be clarified more. This study indicates hypoalbuminemia may be indicators of non-recovery in COV-AKI.
The Prevalence of Insomnia in University Students and Its Relationship with Quality of Life: A University Sample
Authors: lmaz Yavuz , u Nesim
Published: September 2022

Aim: The goal of this study was to find out how common sleep disorders are among university students and to see how they relate to depression, anxiety, stress levels, personality factors, and overall quality of life.
Materials and Methods: This study comprised a total of 856 students. Initially, Pittsburg Sleep Quality Index (PSQI) and a Sociodemographic Data Form were applied. Those with a PSQI score of ≥6 were scheduled for a second interview and a psychiatric interview was conducted. The participants were divided into two groups as those diagnosed with insomnia (n=104) and control group (n=95). Both groups were applied Insomnia Severity Index (ISI), Depression Anxiety Stress Scale (DASS), Eysenck Personality Questionnaire-Revised/Abbreviated Form (EPQR-S), and Short Form-36 (SF-36).
Results: Point prevalence of insomnia among study participants was 12.1%. Insomnia was more common in those who have just started university, were staying in dormitories, had a physical disorder, were smoking, had no regular breakfast habits, and were using electronic media more frequently. When compared to the control group, the ISI scores, DASS depression, anxiety, and stress scores, and EPQR-S neuroticism scores were statistically substantially higher in the insomnia group. Physical function, role limitation (physical), pain, general health, vitality (energy), social function, role limitation (emotional), and mental health were statistically substantially lower in the insomnia group than in the control group on the SF-36 subscales.
Conclusion: Insomnia is a prevalent affliction among college students. In students with insomnia, depression and anxiety disorders are more common. Insomnia is also linked to a low quality of life and certain personality features.
Local Anesthetic Systemic Toxicity: Evaluation of Awareness and Knowledge Levels of Anesthesia Technicians
Authors: n Pelin
Published: September 2022

Objective: The aim of our study is to measure the levels of knowledge about the systemic toxicity of local anesthetics among anesthesia technicians, who will be the first to recognize local anesthetic systemic toxicity in the absence of an anesthesiologist or related physician.
Materials and Methods: A total of 196 anesthesia technicians working at different hospitals were included in the study. A questionnaire was used as a data collection tool. The data obtained were evaluated statistically using IBM SSPS Statistics 25.0 for Windows.
Results: When the distribution of the participants according to knowledge of systemic toxicity was examined, it was seen that 56.1% of the participants answered “yes” to having such knowledge, 24% of the participants said “no,” and 19.9% of the participants did not remember. Regarding what must be done urgently in the event of local anesthetic systemic toxicity development, 74% of the participants said that the administration of local anesthetic should be stopped, 84.2% said that airway safety should be ensured, 100% said that oxygen should be administered, 65.3% said that a call for help should be made, 65.8% said that preparations for tracheal intubation should be started, 66.3% said that a safe venous line should be opened, 30.1% said that convulsions should be treated, and 51% said that a 20% lipid solution should be administered.
Conclusion: Based on our findings, we conclude that anesthesia technicians need training to increase their awareness of and knowledge about the symptomatology, prevention, and treatment of local anesthetic systemic toxicity.
Keyword: Drug toxicity, Awareness, Technicians.
Association Analysis of Two Polymorphisms in Neuregulin 1 Gene in a Turkish Schizophrenia Sample
Authors: l Ay , Kartalc kr , zen Mustafa
Published: September 2022

Objective:
NRG1 is one of the genes that was reported to have susceptibility alleles effecting the phenotype of schizophrenia. There are many SNPs (single nucleotide polymorphisms) located in the NRG1 gene with suspected alleles which were associated to schizophrenia. In this study, we investigated the potential associations between schizophrenia and NRG1 polymorphisms rs4560751 and rs3802160.

Material and Methods:
We collected DNA samples of 96 patients diagnosed for schizophrenia and 100 healthy controls living in Malatya-Turkey. We genotyped two NRG1 SNPs mentioned above and compared case and control groups for distributions of alleles and genotypes. We also tested the potential associations in dominant models. We used Chi-Squared test for hypothesis testing.

Results:
No significant differences were seen between the groups of patients and controls for the distributions of alleles and genotypes of two NRG1 SNPs we have screened.

Conclusion:
The results of our experiments and statistical tests we have done indicated that in the population we have screened there was no sufficient evidence to support the association of NRG1 SNPs rs4560751 and rs3802160 with schizophrenia.
Predictive Value of the Interface Pressure and Frequency of Pressure Ulcer in Elderly Patients in the İnternal Medicine Intensive Care Units
Authors: Bulut Ebru , ne Zeynep
Published: September 2022

Aim: Pressure ulcers develop frequently in immobile elderly. Pressure is extrinsic factor and it plays a major role in ulcer development. Nurses use a pressure ulcer risk assessment tools and risk assessment effectives as a means to ulcers preventing. To determine frequency and predictive value of interface pressure in pressure ulcer development in elderly patients hospitalized in internal medicine intensive care units.
Materials and Methods: The study involved 140 patients admitted to internal intensive care clinics between May 2018 and August 2018 without pressure ulcers and who stayed in the ICU for more than 72 hours. Participants were scored using the Braden scale and were examined for the risk level of pressure ulcers. The inclusion criteria were age over 65 years and having a high risk of developing pressing ulcers. Patients were evaluated by “Questionnaire Form,“ Braden Risk Assessment Scale” and “ Palm Q-Portable Interface Pressure Sensor” every two days during their stay in the clinic.
Results: Pressure ulcer developed in 22.1% of the patients but it didn’t develop in any of the oral feeding patients. The mean time for ulcer to develop was 6.90 (standard deviation 2.9) days. In patients with pressure ulcers, while the mean interface pressure value was 47.75 (standard deviation 6.79) mmHg at the beginning of the final evaluation position, 51.25 (standard deviation 6.71) mmHg at the end of the position.
Conclusion: In all interface pressure measurements of patients who developed pressure ulcer, the interface pressure values increased at the end of the position compared to the beginning of the position.
Comparison Of C-Reactive Protein And High-Sensitivity C-Reactive Protein in Acute Appendicitis Patients With Normal White Blood Cells Counts
Authors: k Dr , cel Assoc , Turan Dr , n Prof
Published: September 2022

Objective: Acute appendicitis is one of the main causes of acute abdominal pain. The main goal of treatment is early diagnosis and emergency surgical intervention. Late diagnosis leads to complex acute appendicitis (gangrene, abscess, and perforation). Although the signs and symptoms of acute appendicitis are well known, it is sometimes difficult to diagnose. Various laboratory markers have been studied for the diagnosis of acute appendicitis, but none showed superiority over physical examination or imaging. In addition, the superiority of high-sensitivity C-reactive protein (hs-CRP) over C-reactive protein (CRP) in patients diagnosed with acute appendicitis has not been evaluated in any study to date. With the current study, we aimed to compare CRP and HsCRP values in patients with acute appendicitis whose white blood cells (WBC) are in the normal range.

Materials and methods: In this study, serum levels of CRP and hs-CRP were measured in 45 patients with acute appendicitis (who had normal WBC values) and 42 healthy controls. The results obtained were statistically evaluated in terms of significant differences between the two study groups. In addition, ROC (Receiver Operating Characteristic) analysis was performed to determine the power of CRP and HsCRP in the differential diagnosis of acute appendicitis.

Results: CRP and HsCRP levels of the patient group were significantly higher than the control group (0,002 and <0,001 respectively). ROC analysis results revealed that HsCRP has higher diagnostic power than CRP in discriminating between AA patients and healthy people.

Conclusion: This study showed that HsCRP may be a more effective biochemical marker in the diagnosis of acute appendicitis instead of CRP.
EFFECTIVENESS OF CT ANGIOGRAPHY AND CT PERFUSION IMAGING PERFORMED ON 16-SLICE CT SCANNER IN PREDICTION OF ACUTE INTRACRANIAL PARENCHYMAL HEMATOMA PROGRESSION: A RETROSPECTIVE STUDY
Authors: Ozpar Rifat , Kocaeli Hasan , Hakyemez Bahattin
Published: September 2022

Purpose: To compare the effectiveness of computed tomography (CT) angiography (CTA), CT Perfusion (CTP) spot signs, and CTP parametric maps obtained from the examinations performed on a 16-slice CT for predicting acute intraparenchymal hematoma (AIPH) progression.

Methods: Thirty-one patients who presented to the emergency department with acute neurological symptoms and were diagnosed with AIPH on initial head CT examination were included in this study. The patients were administered CTA and CTP within 3 hours of the diagnosis of AIPH and follow-up head CT 24 hours after the first diagnosis. Diagnostic performance of spot signs in CTA and CTP, abnormality presence in CTP parametric maps, and the relationship between them and hematoma progression were investigated.

Results: Sensitivity, specificity, positive predictive, negative predictive and accuracy values in predicting hematoma progression were 85.7%, 95.8%, 95.8%, 85.7%, and 93.5% for CTA spot sign; 71.4%, 95.8%, 83.3%, 92% and 83.9% for CTP spot sign; 14.3%, 87.5%, 100%, 87.5% and 70.9% for all CTP parametric maps, respectively. CTP parametric maps could not be created due to motion artifacts in 19.4% of patients.

Conclusion: The spot sign is a valuable finding that predicts hematoma progression on CTA and CTP examinations performed on a 16-slice CT device. On the other hand, perfusion maps obtained from CTPs are less effective in predicting hematoma progression. Motion artifacts can be seen with a significant frequency in AIPH cases and may prevent the formation of parametric perfusion maps. Limitations of CT equipment and methods should be considered when deciding on the correct method to predict the hematoma progression.
Immunoexpression of androgen receptor in genital tissues of male BALB/c mice
Authors: R Fatih
Published: September 2022

Aim: Androgens are hormones that are essential for the differentiation and development of male genital organs, preserving their structural features and maintaining their functions. These hormones exert their effects on target tissues mainly through androgen receptors (AR). The aim of this study was to determine the AR immunoexpression pattern in the genital tissues of male mice.
Materials and Methods: A total of 6 BALB/c male mice were anesthetized with ether, and the genital tissues, which were quickly removed from the body, were fixed in Bouin’s solution for 18 hours. Tissues that underwent routine histological procedures after fixation were embedded in paraffin. Tissue sections cut with a thickness of 5 µm from paraffin blocks were taken on a slide and examined by staining with immunohistochemical methods.
Results: AR-positive immunostaining in the testis was observed only in somatic cells such as Sertoli, peritubular myoid cells, and Leydig cells. Germ cells were AR-negative. In the caput epididymis, ductus deferens, and seminal vesicle, AR positive immunoexpression was observed in stromal cells, especially epithelial cells. Although AR-positive staining was observed in some of the epithelial and stromal cells in these organs, some of them were AR-negative.
Conclusion: In the current study, it was determined that the AR expression pattern in the genital tissues of male BALB/c mice was similar to that in other species, although there were minor differences. The findings support the hypothesis that androgens exert their effects in testis mainly through somatic cells, and their effects in other genital tissues through epithelial cells, and the fact that androgens/ARs are essential for maintaining the structures and functions of male genital organs.
Parotid masses: The effectiveness of preoperative diagnostic methods on definitive diagnosis
Authors: kaya Serhat , Altunta Ahmet
Published: September 2022

Objective: 85% of neoplasms originating from the major salivary glands are seen in the parotid gland. The diagnosis of parotid masses can sometimes be made with a simple anamnesis and physical examination. However, despite all advanced examinations and biopsies, the preliminary diagnosis can be very different from the postoperative pathological diagnosis due to the unique embryological and anatomical features of the parotid gland. In our study, we aimed to evaluate the relationship between the accuracy of diagnostic tools and postoperative pathological diagnoses in patients who underwent parotidectomy.
Materials and Methods: The files of patients who underwent surgery between 2014 and 2019 due to a parotid mass were evaluated. Preoperative neck ultrasound, computed tomography, magnetic resonance imaging, and fine-needle aspiration biopsies were evaluated. Postoperative pathological diagnoses and preoperative examination findings, imaging methods, and preliminary diagnoses obtained according to fine-needle aspiration biopsy results were compared and sensitivity, specificity, and accuracy rates were determined.
Results: According to the postoperative pathologic diagnosis, 31 of the tumors were reported as benign (91.1%) and 3 as malignant (8.8%). Ultrasound defined 10 of 17 patients with benign pathology as benign (58.8%) and 7 as nondiagnostic (41.1%). Magnetic resonance imaging reported 11 of 15 benign cases as benign (73.3%), and defined 1 malignant case as nondiagnostic. It was observed that 20 of the patients who underwent fine-needle aspiration biopsy were reported as benign and 4 as nondiagnostic. Postoperative pathology results of 2 of 24 patients were reported as malignant, and 22 of them as benign.
Conclusion: Although magnetic resonance imaging gives the most accurate information among the imaging methods evaluated for preoperative parotid masses, it cannot always make a definitive diagnosis. Although fine-needle aspiration biopsy is useful in distinguishing between malignant and benign tumors, malignant tumors can be reported as benign.
A SEMI-DEFECTED GROUND PLANE AND A BINARY GENETIC ALGORITHM FOR DESIGNING A VERY COMPACT TRIPLE-BAND PIFA ANTENNA
Authors: Wakrim Layla , Khabba Asma , Amadid Jamal , Ibnyaich Saida
Published: September 2022

we suggest in this study a very compact triple band PIFA antenna for mobile and wireless applications.by using the binary genetic algorithm and a semi-defected ground plane. This antenna with the dimension of 38×40×1.9 mm3 is dedicated to LTE Band 11 (1427.9-1495.9 MHz), HIPERLAN/2 (5.15-5.35 GHz), WLAN (5.15-5.35 GHz) and 5G Sub-6GHz applications. To accomplish triple-band operation with acceptable performance purpose of using the genetic algorithm is to dictate the form of the ground plane of the antenna. The simulation results showed that the developed PIFA antenna has optimal operation on three frequencies. The first resonance frequency is 1.32 GHz with a bandwidth (S11 < -10 dB) from 1.28 GHz to 1.38 GHz. The middle and higher bands are centred respectively at 3.12 GHz and 5.2 GHz, with a bandwidth from 3.05 to 3.17 GHz and 4.93 to 5.44 GHz, respectively.
Determining job satisfaction and job stress levels of nurses during the novel coronavirus (COVID-19) pandemic: A cross-sectional survey
Authors: Kayaoglu Kubra , Aslanoglu Eren
Published: September 2022

This study aims to determine the job satisfaction and job stress experienced by nurses during the COVID-19 pandemic. This descriptive study was conducted with 129 nurses working in a pandemic hospital in a province in eastern Turkey. This study was carried out between June 2021 and January 2022, after obtaining ethical committee approval. "Nurse Information Form", "Minnesota Satisfaction Questionnaire (MSQ)", and "Perceived Job Stress Scale (PJSS)" was used to collect the data. The data were collected by the researchers using the online data collection method. Besides descriptive statistics (mean, standard deviation, frequency), Mann-Whitney U Test, Kruskal Wallis-H Test, and Spearman’s Correlation Analysis were used in the data assessment, and significance was evaluated at the level of p <0.05. It was found that the mean scores of the nurses were 3.07±0.82 for overall MSQ, 2.17±0.35 for the subscale of Intrinsic Satisfaction and 2.10±0.46 for the subscale of Extrinsic Satisfaction. They obtained a total mean score of 3.27±0.82 from the Perceived Job Stress Scale. A significant negative correlation was found between job satisfaction and job stress experienced by the nurses during the COVID-19 pandemic. It was found that during the pandemic, the nurses had a high level of job stress and a moderate level of job satisfaction. As their job stress increased, their job satisfaction decreased. In line with these results, attention should be paid to the mental status of nurses, and job stress management training should be given to obtain job satisfaction and reduce job stress.
The effect of Covid-19 phobia on work stress and psychological resilience of nurses exposed to surgical smoke in the operating room
Authors: Kapikiran Gurkan , Cici Remziye , Topdemir Esra
Published: September 2022

The purpose of the study is to determine the effect of Covid-19 Phobia on the work stress and psychological resilience of nurses exposed to surgical smoke in the operating room emergency surgical interventions. This study was designed as descriptive and correlational research, and it was conducted with 160 nurses working in the operating room units of three different hospitals in Türkiye between the dates of August 2020 and May 2021. The work stress scale, brief resilience scale, and Covid-19 phobia scale (C19P-S) were used for data collection. It was determined that the mean work stress score of the nurses was high with a score of 40.11±4.91, the mean score for psychological resilience was moderate with a score of 15.00±3.95, and the mean score for C19P-S was high with a score of 71.58±15.45. There was a significant negative strong (r: -.706) correlation found between Covid-19 phobia and psychological resilience. It was found that there was a positive moderate significant correlation (r: .589) between Covid-19 phobia and work stress (p<0.05). Covid-19 phobia was determined high for nurses exposed to surgical smoke, Covid-19 phobia increased work stress for nurses and negatively affected their psychological resilience level.
Evaluation of preoperative anxiety in cancer patients: Experience of a single center
Authors: Duymus Mehmet , Urfali Senem , Ugur Mustafa , Dal Mehmet , Donmez Yasemin , Bag Yusuf , Temiz Muhyittin
Published: September 2022

Anxiety disorder is observed in half of the patients in the preoperative period. Psychological disorders are also frequently observed in cancer patients and need to be supported. The aim of the present study is to determine the level of preoperative anxiety in patients with malignant and benign diagnoses who were planned for elective surgery and to reveal its relationship with socio-demographic data. A tertiary hospital-based cross-sectional study was conducted in the general surgery clinic between June 1, 2021- March 31, 2022, on 158 patients who underwent elective surgery. Participants were evaluated in two groups depending on their diagnosis; the cancer group and the benign group. The socio-demographic data were recorded and the level of anxiety was determined by the Beck Anxiety Inventory (BAI). The median age of participants was 55 (19-78) years. There were 72 (45.6%) patients in the cancer group and 86 (54.4%) patients in the benign group. There was no significant difference in age, gender, marital status, job, level of income, and family cancer history between the two groups. There were significant differences between the groups in level of education, and previous surgical history (p=0.035, and p=0.037, respectively). BAI scores of the cancer group and control group were 10.5 (0-35) and 5 (0-49), respectively (p<0.001). The level of anxiety in the cancer group was also significantly higher than in the benign group (p<0.001). Cancer patients have more anxiety during the preoperative period than patients who were with benign diseases. We believe that previous surgical history and education level are other factors that affect anxiety.
Can eosinophil to monocyte ratio be a new marker for recurrence in graves' disease?
Authors: Baser Ozden , Koseoglu Derya , Catak Merve
Published: September 2022

Prognostic parameters are crucial in the choice of treatment in Graves' disease (GD), thus,these parameters may not be easily achievable in all situations. However hematological parameters is important in inflammation and easy to obtain. In this study we aimed to elucidate whether these parameters could determine the prognosis in patients with Graves Disease. This retrospective analysis consisted of 114 individuals with a diagnosed with GD. The enrolled patients were treated with anti-thyroid drugs for an average of 14 months and the mean follow-up period after treatment discontinuation was 17.4 months. After the follow-up period subjects have been segmented to 2 groups as: Group 1 relapsed (n:61) and Group 2 non-relapsed (n:53). The neutrophil to lymphocyte ratio (NLR) of the relapsing individual was statistically significantly higher compared to other group, while the eosinophil to monocytes ratio (EMR) was lower. In the multiregression analysis, both parameters were found to be independent risk factors in predicting relapse [(OR=3.1, p:0.026 for NLR) (OR=1.5, p<0.001 for EMR)]. In addition, a value of 0.17 EMR had 70% sensitivity and 80% specificity in determining recurrence. EMR was found to be an independent predictor of prognosis with high specificity. The calculation of EMR before initiating treatment could provide beneficial outcomes for the choice of treatment in patients with GD.
Influence of Sociodemographic and Clinical Characteristics on Sexual Function Domains of Health Related Quality of Life in Multiple Sclerosis Patients
Authors: Hajric Selma , Serdarevic Amra , Sulejmanpasic Gorana , Suljic Enra
Published: September 2022

Background: Multiple sclerosis is a progressive inflammatory disease of the the central nervous system. Problems with sexual functions are the common features of multiple sclerosis and important factor that contribute to the quality of life among affected persons. Objective: The aim of the study was to evaluate the influence of sociodemographic and clinical characteristics on sexual functions domains of health related quality of life (HRQOL) in multiple sclerosis patients. Methods: This study included 100 MS patients treated at the Department of Neurology, Clinical Center University of Sarajevo. Inclusion criteria were an Expanded Disability Status Scale score between 1.0 and 6.5, age between 18 and 65 years, stable disease on enrollment. HRQOL was evaluated by the Multiple Sclerosis Quality of Life-54 questionnaire. Mann-Whitney and Kruskal-Wallis test were used for comparisons between sociodemographic and clinical characteristics and HRQOL scores. Results: Out of 60% of patients reported to have sexual dysfunction, and 55 % were female patients. Younger patients had statistical significant higher median value of sexual function score (91.68 vs. 58,28, p=0.001) and satisfaction with sexual life scores (62.5 vs 37.5 , p =0.019) comparing to older patients. Employed patients also showed statistical significant higher median value of sexual function score (82 vs. 66.7, p=0.003) comparing to unemployed patients and also statisticaly significant higher median scores considering satisfaction with sexual life among employed patients (p=0,001). There were no differences in sexual functions scores considering gender, marital status and education. Patients with higher level of disabilty, progressive type of disease, more relapses and longer diseas duration had statistical significant lower median value of sexual function score and also satifaction with sexual life scores, except for disease duration Conclusion: Aging, dysability and progression are major factors that contribute to lower sexual function scores and satisfaction with sexual life among multiple sclerosis patients. Althoug women reported sexual problems more often then men, impact of these problems on quality of life are similar in men and women with MS.