bluuebunny/crossref_metadata_2025 huggingface dataset:
The breath shape controls intonation of mouse vocalizations
Authors: MacDonald Alastair , Hebling Alina , Wei Xin Paul , Yackle Kevin
Published: July 2024

Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct sounds with different denotations, like in tonal languages and, perhaps, the 10 sounds in the murine lexicon. A basic tone is created by exhalation through a constricted laryngeal voice box, and it is thought that more complex utterances are produced solely by dynamic changes in laryngeal tension. But perhaps, the shifting pitch also results from altering the swiftness of exhalation. Consistent with the latter model, we describe that intonation in most vocalization types follows deviations in exhalation that appear to be generated by the re-activation of the cardinal breathing muscle for inspiration. We also show that the brainstem vocalization central pattern generator, the iRO, can create this breath pattern. Consequently, ectopic activation of the iRO not only induces phonation, but also the pitch patterns that compose most of the vocalizations in the murine lexicon. These results reveal a novel brainstem mechanism for intonation.
Perceptual error based on Bayesian cue combination drives implicit motor adaptation
Authors: Zhang Zhaoran , Wang Huijun , Zhang Tianyang , Nie Zixuan , Wei Kunlin
Published: July 2024

The sensorimotor system can recalibrate itself without our conscious awareness, a type of procedural learning whose computational mechanism remains undefined. Recent findings on implicit motor adaptation, such as over-learning from small perturbations and fast saturation for increasing perturbation size, challenge existing theories based on sensory errors. We argue that perceptual error, arising from the optimal combination of movement-related cues, is the primary driver of implicit adaptation. Central to our theory is the increasing sensory uncertainty of visual cues with increasing perturbations, which was validated through perceptual psychophysics (Experiment 1). Our theory predicts the learning dynamics of implicit adaptation across a spectrum of perturbation sizes on a trial-by-trial basis (Experiment 2). It explains proprioception changes and their relation to visual perturbation (Experiment 3). By modulating visual uncertainty in perturbation, we induced unique adaptation responses in line with our model predictions (Experiment 4). Overall, our perceptual error framework outperforms existing models based on sensory errors, suggesting that perceptual error in locating one’s effector, supported by Bayesian cue integration, underpins the sensorimotor system’s implicit adaptation.
Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency
Authors: Hensel Zach
Published: July 2024

Accurate estimation of the effects of mutations on SARS-CoV-2 viral fitness can inform public-health responses such as vaccine development and predicting the impact of a new variant; it can also illuminate biological mechanisms including those underlying the emergence of variants of concern. Recently, Lan et al. reported a model of SARS-CoV-2 secondary structure and its underlying dimethyl sulfate reactivity data (Lan et al., 2022). I investigated whether base reactivities and secondary structure models derived from them can explain some variability in the frequency of observing different nucleotide substitutions across millions of patient sequences in the SARS-CoV-2 phylogenetic tree. Nucleotide basepairing was compared to the estimated ‘mutational fitness’ of substitutions, a measurement of the difference between a substitution’s observed and expected frequency that is correlated with other estimates of viral fitness (Bloom and Neher, 2023). This comparison revealed that secondary structure is often predictive of substitution frequency, with significant decreases in substitution frequencies at basepaired positions. Focusing on the mutational fitness of C→U, the most common type of substitution, I describe C→U substitutions at basepaired positions that characterize major SARS-CoV-2 variants; such mutations may have a greater impact on fitness than appreciated when considering substitution frequency alone.
Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency
Authors: Hensel Zach
Published: July 2024

Accurate estimation of the effects of mutations on SARS-CoV-2 viral fitness can inform public-health responses such as vaccine development and predicting the impact of a new variant; it can also illuminate biological mechanisms including those underlying the emergence of variants of concern
1
. Recently, Lan et al reported a high-quality model of SARS-CoV-2 secondary structure and its underlying dimethyl sulfate (DMS) reactivity data
2
. I investigated whether secondary structure can explain some variability in the frequency of observing different nucleotide substitutions across millions of patient sequences in the SARS-CoV-2 phylogenetic tree
3
. Nucleotide basepairing was compared to the estimated “mutational fitness” of substitutions, a measurement of the difference between a substitution’s observed and expected frequency that is correlated with other estimates of viral fitness
4
. This comparison revealed that secondary structure is often predictive of substitution frequency, with significant decreases in substitution frequencies at basepaired positions. Focusing on the mutational fitness of C
→
T, the most common type of substitution, I describe C
→
T substitutions at basepaired positions that characterize major SARS-CoV-2 variants; such mutations may have a greater impact on fitness than appreciated when considering substitution frequency alone.
Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia
Authors: Ichimura Yoshinobu , Sugiura Yuki , Katsuragi Yoshinori , Sou Yu-Shin , Uemura Takefumi , Tamura Naoki , Komatsu-Hirota Satoko , Ueno Takashi , Koike Masato , Waguri Satoshi , Komatsu Masaaki
Published: July 2024

Protein spinster homolog 1 (SPNS1) is a lysosomal transporter of lysophospholipids and sphingosine, which has recently been identified to be mutated in patients with neurodegeneration. However, its physiological role, especially in the nervous system, remains largely unknown. In this study, we generated, for the first time, nervous system-specific
Spns1
knockout mice,

Spns1
flox/flox

;nestin-
Cre
, and found that the mutant mice develop neurological symptoms, such as epilepsy, and growth retardation, and die by 5 weeks of age. The mutant mice exhibited dysmyelination and oligodendrocyte shedding, while maintaining the neurons. Mutant mouse brains showed accumulation of lysophospholipids, predominantly in regions, such as the olfactory bulb and hippocampus. Furthermore, whereas sphingosine accumulated in the mutant mouse brain, the levels of ceramide and sphingoglycolipids, which are the main myelin components, were decreased. Our findings imply that abnormal sphingosine metabolism causes dysmyelination and white matter dysplasia in brain-specific
Spns1
-knockout mice, and indicate a possible role of SPNS1 mutation in the pathogenesis of congenital cerebral white matter dysplasia in humans.
Renal Actinomycosis Camouflaging as Malignancy: A Diagnostic Challenge
Authors: Mathew Jassal , Vijay Smrthi , Joseph Lincy
Published: July 2024

Actinomycosis is an unusual infection that typically appears in the thoracic, cervicofacial, and abdominal areas. However, the occurrence of renal actinomycosis in adults remains rare, with few cases reported since 1990. Actinomycosis is often considered “the most misdiagnosed disease” due to its tendency to be overlooked even by experienced clinicians. Hereby authors report a case of a 55-year-old male with pyrexia of unknown origin and weight loss, presenting with pallor upon general examination. Further investigation revealed microcytic hypochromic anaemia and neutrophilic leukocytosis on peripheral blood smear. A heterogeneous mass with internal vascularity in the left kidney was identified on abdominal ultrasound. Subsequent Computed Tomography (CT) abdomen confirmed an ill-defined lesion in the mid and lower pole of the left kidney, with extrarenal extension into the perinephric space, and a filling defect in the left renal vein. A provisional diagnosis of a left renal tumour infiltrating the spleen and splenic flexure of the colon was made. The patient then underwent a left radical nephrectomy, splenectomy, and limited colonic resection. Histopathological examination confirmed actinomycosis with abscess formation in the kidney and colon. The patient was treated with crystalline penicillin for eight weeks until considered disease-free. Renal actinomycosis poses challenges in diagnosis due to its ambiguous clinical and laboratory features. Often mimicking malignant neoplasms on imaging, it can confuse even experienced clinicians. Early detection is crucial for precise medical intervention and to reduce unnecessary surgeries.
Sociodemographic Determinants of Burden and Resilience among Caregivers of Children Diagnosed with Cancer: A Cross-sectional Study
Authors: Thakur Dipti , Aleem Sheema , Karia Sagar , Mahajan Amita , Verma Chandrika
Published: July 2024

Introduction: Caregiving encompasses various challenges and adversities, with resilience playing a crucial role in navigating these hurdles. However, resilience is influenced by individual characteristics, prompting an examination of how demographic variables impact resilience and caregiver burden among caregivers of cancer patients in India. Aim: To investigate the relationship between demographic variables and resilience, as well as caregiver burden, among caregivers of cancer patients in India. Materials and Methods: In this cross-sectional study, a clinical sample of 125 caregivers {males (46.4%) and females (53.6%)} from Indraprastha Apollo Hospital, New Delhi, India was assessed. Resilience was measured using the Connor-Davidson Resilience Scale (CD-RISC), while caregiver burden was evaluated using The Burden Assessment Schedule (BAS). Various demographic factors, including gender, age, qualification, socio-economic status, loss of work, number of children, travel for treatment, duration of treatment, type of illness, and employment status, were examined. T-tests and Analysis of Variance (ANOVA) were utilised for data analysis. Results: The predominance was of female caregivers, comprising 67 (53.6%) individuals, primarily falling within the age bracket of 30-40 years demographic variables significantly influenced resilience levels among caregivers (p-value ranged from 0.001 to 0.86). However, caregiver burden was not significantly impacted by demographics overall (p-value ranged from 0.24 to 0.98), although certain sub-domains were affected. Notably, male caregivers demonstrated higher levels of resilience compared to females (T=9.88, p=0.001), with postgraduate qualifications correlating with increased resilience (mean: 17.02) and lower caregiver burden (mean: 81.53). Additionally, age did not significantly affect the results (effect size ranged from 0.10 to 0.86). Conclusion: The study underscores the importance of tailored support strategies for caregivers, particularly focusing on enhancing resilience among female caregivers and addressing specific burden dimensions affected by demographic factors of socio-economic status and qualification. Overall, resilience was affected by gender, socio-economic status, number of children, travel, duration of treatment, and employment significantly, but caregiver burden was not significantly affected by any demographic variable.
The Effect of Awareness on Big Data Adoption Readiness in Public Sector Auditing in Tanzania: Assessing TAM Model
Authors: Moshi Albert , Sife Alfred , Matto George
Published: July 2024

Big data plays a pivotal role in auditing by unlocking unprecedented opportunities to extract meaningful insights from vast volumes of data. However, the usage of big data in public sector auditing in Tanzania is still limited, highlighting the need to explore the factors that influence its adoption readiness. This study explores the effect of awareness on auditors’ perception towards big data adoption readiness in public sector auditing. Specifically, it focuses on two key Technology acceptance model (TAM) factors, which are perceived ease of use and perceived usefulness. Data were collected from a sample of 221 auditors by using random sampling technique. Confirmatory factor analysis using Partial least square structural equation modelling performed the analysis. The findings revealed that awareness on big data adoption readiness plays a crucial role in shaping the perceived ease of use and perceived usefulness of big data technology. Higher levels of awareness are associated with increased perceived usefulness and perceived ease of use and consequently perceived usefulness was found as a major predictor of big data adoption readiness. The study concludes that empowering auditors with a deeper understanding of big data and its practical applications in public sector auditing could significantly increase their adoption readiness. Specifically, the findings suggest that providing targeted training programs, workshops, and seminars to enhance auditors' awareness and knowledge of big data technologies and their potential benefits would be an effective strategy to promote the readiness for big data adoption.
Spider Species Identification: Bridging Traditions with Molecular and Deep Learning Approaches
Authors: Shrivastava Aakriti , Sharma V. K.
Published: July 2024

This article provides an in-depth review of various methods employed in the identification and sequencing of spiders, highlighting the advancements and challenges in the field. With the increasing importance of spiders in ecological studies, medical research, and biodiversity conservation, accurate identification and genetic analysis have become crucial. This review discusses traditional and modern techniques, shedding light on their applications, limitations, and future prospects.
The exploration begins with an analysis of taxonomists' etymological choices, examining patterns in naming conventions across continents and centuries. Traditional morphological identification, anchored in backbone taxonomy, dichotomous keys, and statistical analyses, highlights the advantages and challenges of relying on observable features. The study transitions to molecular techniques, elucidating the applications and challenges of DNA barcoding, Next-Generation Sequencing (NGS), and metabarcoding in spider identification. The integration of deep learning models, exemplified by the YOLOv7-based Spider Identification APP, represents a landmark in computer vision for efficient and user-friendly spider species recognition. The study's multifaceted approach provides a nuanced understanding of spider taxonomy, bridging historical practices with state-of-the-art technologies, and lays the groundwork for future advancements in the field.
Phytochemical Screening of Artocarpus odoratissimus (Marang) Seed Extract and Its Antimicrobial Potential against Staphylococcus aureus & Escherichia coli
Authors: Jr Genaro F. Alderite
Published: July 2024

Aims: Artocarpus odoratissimus, often called locally as "Marang," is well-known in the Philippines for its economic and nutritional value. No phytochemical studies have been conducted on Artocarpus odoratissimus cultivated locally in Davao City. The purpose of this study is to establish an initial chemical profile of the species by examining the secondary metabolites found in Artocarpus odoratissimus seed ethanol and methanol extract and determining their antimicrobial activity against selected soil microorganisms, particularly Staphylococcus aureus and Escherichia coli.
Study Design:  Laboratory experiments were conducted at San Pedro College, Davao City, to assess the qualitative phytochemical components and antibacterial activity of crude ethanolic and methanolic extracts of A. odoratissimus against selected soil bacteria.
Place and Duration of Study: At San Pedro College, the study was conducted in the science laboratories between December 2022.
Methodology: Seed extracts were prepared using ethanol and methanol solvents through maceration techniques. Standard methods were employed to identify the presence of various phytochemicals qualitatively. The disc diffusion method was utilized to assess the effectiveness of the extracts against specific bacterial strains, including E. coli and S. aureus. The extent of inhibition zone formation was measured to determine the antimicrobial potential.
Results: Qualitative analysis revealed the presence of various secondary metabolites in Artocarpus odoratissimus seed extracts, including flavonoids, tannins, phenolics, saponins, steroids, terpenoids, and alkaloids. Furthermore, the seed extracts exhibited limited antimicrobial activity against Escherichia coli and Staphylococcus aureus as determined by the zone of inhibition assay.
Conclusion: Seed extracts from Artocarpus odoratissimus showed promise due to the presence of health-promoting compounds. While initial tests against bacteria were limited, further research can improve extraction methods and explore how these compounds work together for broader antibacterial effects. Future studies should also precisely measure the compounds, test against more bacteria, and explore potential uses based on the extract's profile.
Study of Regular Variations in Vertical Total Electron Content (VTEC) from 2013 to 2021 at Station BF01 in Ouagadougou
Authors: Ouédraogo Pouraogo , Guibula Karim , Diabaté Abidina , Fleury Rolland , Ouattara Frédéric
Published: July 2024

This paper presents the regular variations of the Vertical Total Electron Content (VTEC) at station BF01 (Lat. = 12.3714 N and Long. = -1.5197 W) in Ouagadougou (Burkina Faso) located in the trough of the equatorial ionisation anomaly near the northern ridge of the West African zone. The period studied runs from 2013 to 2021. The VTEC is extracted from the raw Global Navigation Satellite System - Continuously Operating Reference Station (GNSS-CORS) data recorded at station BF01 during the study period. The analysis of diurnal variations showed three types of profiles with a dominant profile being the Dome type. Generally speaking, the daily VTEC profiles show a minimum at dawn between 4:00 UT and 6:00 UT followed by a rapid increase from sunrise to a maximum around 15:00 UT, then a gradual decrease in the late afternoon and during the night to reach the minimum just before sunrise. On some days, a second nocturnal maximum is observed between 19:00 UT and 20:00 UT. Seasonal and annual variations revealed that for each year, the highest VTEC values are observed during the equinox, although with higher values at the March equinox. It was also found that the lowest VTEC values are recorded at the summer solstice in each year. The regular variations in the VTEC at station BF01 during the study period therefore highlight three anomalies: the semi-annual anomaly, the equinoctial asymmetry and the winter anomaly. Furthermore, the VTEC at station BF01 in Ouagadougou evolves in phase with the sunspot cycle.
Aquatic Insects Consumed in Togo: Diversity and Nutritional Potential
Authors: Badanaro Fegbawe , Tagba Pelei , Melila Mamatchi
Published: July 2024

This study identified the species of aquatic insects consumed in Togo, and determined the chemical composition of the most common species (Cybister tripunctatus (Sharp, 1882) (Coleoptera: Dytiscidae)). This was achieved through ethnoentomological surveys and species identification at the insectarium of the University of Lomé and it provided information on aquatic insects consumed in Togo. Samples of C. tripunctatus were collected in the three localities where ethnoentomological surveys were carried out. Ash, protein, vitamin and lipid contents were determined according to AOAC reference methods. Fiber content was determined using the Weende method. Minerals were analyzed by atomic absorption spectrophotometry and colorimetry. Lipid composition in fatty acids was determined by gas chromatography, and protein composition in amino acids was determined by separation of amino acids using the Biochrom 30+ analyzer. Forty-five out of 120 people interviewed from the Moba ethnic group said they occasionally consumed adult dytics. Four species consumed by this aborigine population was identified. None of these species is sold commercially. According to the respondents, the consumption of dytics is motivated by their nutritional and therapeutic virtues. C. tripunctatus consists of 10.32% moisture, 36.52% proteins, 26.98% lipids, 12.60% fibers, 4.94% carbohydrates, and has an energy value of 1804.19 kJ/100g. All essential amino acids are present in C. tripunctatus.  Lipids are rich in unsaturated fatty acids, particularly essential fatty acids. In terms of micronutrient composition, the species studied is rich in minerals and vitamins. The mineral content is 10.32% and depends on the nature of the minerals present. Vitamins content also varies. The ratios of minerals, and fatty acids are balanced. These data show the socio-economic importance of dytics consumed in Togo and the quantitative and qualitative richness of C. tripunctatus in nutrients. This species could therefore contribute to the nutritional balance of consumers.
Autoregressive Distributed Lag (ARDL) Analysis of the Relationship Between Public Health Expenditure and Economic Growth in Benin
Authors: Ayena Cherif , Biaou Barthelemy , Guidime Camille , Baranon Mouhamadou Djima , Nahini Ambroise Tchando , Soglo Achille Mahuna
Published: July 2024

Aims/ Objectives: To examine the impact of public health expenditure on economic growth in Benin. Study Design: Autoregressive Distributed Lag (ARDL) model analysis approach.Place and Duration of Study: E´ cole Nationale de Statistique, de Planification et de De´mographie (ENSPD), Universit ´e de Parakou, Benin, between January and April 2024.Methodology: This research utilizes data from the World Bank’s World Development Indicators (WDI) database, covering the period from 1977 to 2017. The method used is the Autoregressive Distributed Lag (ARDL) model analysis approach with tree models. The study adopts the human capital production function from Romer (1990) as a base model, which is modified to account for factors influencing the total productivity of the factors, following Romon’s (1998) approach.Results: The associated balance correction was negative and significant for each model, confirming the existence of long-term relationships. The results of the study also reveal that public health expenditure has a negative long-term and positive short-term impact on economic growth in Benin. Moreover, life expectancy at birth, in turn, has a positive effect on economic growth in the short and long term. Furthermore, Benin’s policy of openness to the outside world and the inflation rate has a negative impact in the short and long term on economic growth.Conclusion: The results of the selected model indicate that public health spending has a positive impact on economic growth in Benin in the short term, while its effect is negative in the long term.
Implicações da pós-verdade no comportamento informacional e em informações de saúde
Authors: Suedde Shirley de Souza Felix , Barbosa Ana Cibele de Oliveira , Souza Marco Tulio Moreira de , Santos Vagner Marcelo Ramos , Santos José Carlos Sales dos
Published: July 2024

A pós-verdade, caracterizada pelo uso sistemático de informações enganosas, distorcidas ou falsas para moldar a opinião pública, tem se tornado uma preocupação crescente na sociedade contemporânea e têm causado impactos significativos no comportamento informacional das pessoas. O presente artigo objetiva analisar as implicações da pós verdade no comportamento informacional e em informações de saúde. A metodologia utilizada é uma revisão de literatura, e o resultado de inúmeras discussões realizadas no grupo de pesquisa “Laboratório de Pesquisa em Comportamento Informacional”.  Utilizamos visões de diferentes autores, que compõem os principais entendimentos sobre a origem, conceitos e as implicações da pós-verdade no comportamento informacional, demonstrando como afeta a confiança nas fontes de informação, nas relações sociais, no processo de tomada de decisões. Foram explorados diversos aspectos relacionados à desinformação, incluindo sua definição, o papel do comportamento informacional na sua propagação, as motivações que impulsionam sua disseminação, os aspectos psicológicos, sociais envolvidos nesse processo e como também o impacto da pós-verdade e de fake News em informações de saúde. Concluímos, destacando a importância de se combater os efeitos negativos da pós-verdade, promovendo a educação informacional, literacia em saúde, o pensamento crítico, capacitando as pessoas a verificar fontes, avaliar a credibilidade dos conteúdos e entender a importância de fontes mediadas e responsáveis.
Biblioterapia: mediação da informação e o processo da leitura terapêutica por profissionais da saude do Hospital Martagão Gesteira
Authors: Oliveira Maria Socorro Sobreira , Santos José Carlos Sales dos , Silva Teotonilia Maria Batista da , Macedo Paula Vanessa Franco
Published: July 2024

A biblioterapia, compreendida como a terapia por meio dos livros, pode transmitir informações que possibilitam gerar um estado de enlevo, que desperta emoções e sentimentos em pacientes específicos, como crianças e adolescentes em tratamento de câncer. Nessa perspectiva, esta pesquisa teve por objetivo avaliar como o processo de leitura associada à biblioterapia interfere na dimensão terapêutica em crianças em tratamento de câncer internadas, pelos profissionais da saúde, no Hospital Martagão Gesteira em Salvador-Bahia. Para a concretização da pesquisa, tornou-se necessária a aprovação do Comitê de Ética em Pesquisa da Maternidade Climério de Oliveira da UFBA(CEP/MCO) sob o parecer nº 4.827.922. Participaram da pesquisa de campo 29 crianças em tratamento de câncer internadas no referido hospital e 10 profissionais da saúde. Nos procedimentos metodológicos, adotamos a técnica de observação direta e a técnica de aplicação de Formulários nos Encontros Biblioterapêuticos para analisar entre profissionais da saúde os benefícios percebidos na prática de leitura e contação de histórias no Hospital Martagão Gesteira. A pesquisa ocorreu no âmbito da oncologia pediátrica, especificamente na Sala de Quimioterapia, na Enfermaria e no Ambulatório Oncológico do Hospital Martagão Gesteira, onde ocorrera os Encontros Biblioterapêuticos e a aplicação dos Formulários entre as crianças e os profissionais de saúde. Nosso trabalho foi embasado nos estudos dos teóricos que versam sobre a temática em tela. Na apresentação e discussão dos resultados, podemos inferir que as práticas biblioterapêuticas respondem positivamente no comportamento das crianças em estado de adoecimento, de modo a permitir mudanças expressivas de um estado doloroso e apático para um estado de alegria, bem-estar e calma, como evidenciado pelos respondentes profissionais de saúde. E ao analisarmos o resultado desta pesquisa, observamos que a biblioterapia contribui para a saúde mental e emocional, potencializando a coragem e a alegria, afastando o medo e a ansiedade, e promovendo bem-estar, como foi comprovado na análise dos respondentes, crianças e profissionais de saúde.
Palavras-chave: Biblioterapia. Mediação da Informação Ciência da Informação
construção de diagnósticos arquivísticos: considerações sobre a aplicação da técnica 5W2H na atividade diagnóstica
Authors: Lourenço Felipe Teixeira , Carneiro Andressa Glenda Rodrigues , Silveira Ana Paula de Alcântara
Published: July 2024

O diagnóstico arquivístico é a pedra angular que irá nortear todas as demais atividades arquivísticas. Entendemos que uma forma adequada de sistematizar os resultados apresentados no diagnóstico arquivístico é através da ferramenta metodológica do 5w2h. Esta ferramenta consiste em uma estratégia para estruturar pensamentos, ideias, planejamento e possíveis ações de forma organizada e material através de respostas as seguintes palavras: what, when, why, where, who, how e how Much. Assim, o objetivo deste artigo é refletir sobre a seguinte pergunta norteadora: a utilização da ferramenta metodológica 5w2h pode auxiliar o diagnóstico arquivístico de forma a potencializar suas características de ação política e mediadora da informação de maneira a dar maior visibilidade não apenas ao arquivo, enquanto unidade administrativa, mas também ao profissional arquivista? Para tanto, utilizamos a base de dados da Bracpi no intuito de promover uma revisão bibliográfica de literatura na área da Ciência da Informação que possibilite ponderar acerca da questão proposta neste artigo E a partir da análise da literatura propomos um modelo de diagnóstico arquivístico que se utiliza da técnica 5w2h. Conclui-se que há real possibilidade de que o uso do modelo aqui proposto  pode ocasionar melhoria na comunicação entre as áreas, maior destaque do profissional arquivista e aumento de aprovações de suas ações.
Demonologia e Psicanálise:
Authors: Henriques Rogério Paes
Published: July 2024

Discorre-se sobre as relações entre possessão demoníaca e histeria, tomando-se como referente a psicanálise freudo-lacaniana. A histeria, tanto para Freud quanto para o "primeiro Lacan" (déc. 1950), apontava para aquilo que - futuramente no ensino lacaniano (déc. 1970) - se designaria como uma das posições femininas sexuadas. Freud localiza tal posição no pintor protagonista de "Uma neurose demonológica do século XVII" reescrevendo sua história como um caso paradigmático de histeria masculina. Freud o "historisteriza" [hystorise] - conforme o neologismo de Lacan - e, portanto, o despatologiza.
Trieb à Deriva
Authors: Oliveira Lucas Mota
Published: July 2024

Resumo a ser inserido
Meu Primeiro Sutiã
Authors: Abreu Márcio de
Published: July 2024

Resumo a ser inserido
If We Forgive Our Fathers What is Left
Authors: Rigaud Murilo , Pimentel Santos Santana Coelho João
Published: July 2024

O presente ensaio tem por objetivo realizar uma análise e algumas reflexões acerca do poema forgiving our fathers, publicado por Dick Lourie, contido no livro Ghost Radio (1998). Essa obra literária compreende uma variedade de poemas acerca de artistas clássicos do Rock and Roll, da política americana e de uma nostalgia da juventude nos anos 1950. O poema explora a imagem poética de um pai em meio a cenários contraditórios, refletindo um eu lírico cindido que questiona, por fim, o que restaria após um perdão. O texto lírico pretendido explora uma problemática custosa para a psicanálise: a função paterna. Os comentários acerca dessa imagem poética do pai têm como base os conceitos do Complexo de Édipo, a partir da leitura de Jacques Lacan (1856-1939/2019a; 1856-1939/2019b), e o Mito do Pai Primevo, concebido por Sigmund Freud (1912-1914/2012).
Pharmaceutical Bioburden Testing
Authors: Hentz, PhD Nathaniel G.
Published: February 2013

Manufacturing of pharmaceutical products, whether small molecules or biotherapeutics such as oligonucleotides, monoclonal antibodies, recombinant proteins, vaccines, and blood and plasma products are under regulatory control which demands various safety, efficacy and quality measures. This overview focuses on bioburden and microbial contamination detection, which are critical to overall pharmaceutical product safety. Not only the pharmaceutical products but also the entire manufacturing process from incoming raw materials to fill/finish and final product is tested. Bioburden and microbial detection are also required for process validation, cleaning validation, aseptic operation, qualification of water systems, and personnel monitoring. Included in this overview are the considerations necessary for successful microbial detection as well as some common procedures that are currently used in industry. Since standard industry methodologies rely on microbial growth as part of bioburden testing, a huge lag time exists between sampling and reporting. Therefore, a review of newer, more rapid methodologies is presented. Although newer technologies exist, regulatory hurdles still have to be overcome. As pharmaceutical companies continue to adopt newer technologies for their regulatory filings, there is no doubt that these rapid technologies will become suitable alternatives.
The Hydroxide‐Promoted Catalytic Hydrodefluorination of Fluorocarbons by Ruthenium in Aqueous Media
Authors: Konnick Michael M. , Bischof Steven M. , Periana Roy A. , Hashiguchi Brian G.
Published: February 2013

A ruthenium complex ligated by the non‐innocent protic ligand 2,6‐imidizoylpyridine (IPI) in aqueous potassium hydroxide media is shown to be a suitable catalyst for the CF bond activation and subsequent hydrodefluorination (and hydrogenolysis) of a model fluorocarbon. Furthermore, the conversion of CF bonds was enhanced upon increasing the concentration of potassium hydroxide [KOH]. A simple, non‐ligated heterogeneous analogue derived from ruthenium(III) trichloride trihydrate dissolved in aqueous potassium hydroxide is shown to be an even more active catalyst, capable of hydrodefluorination of aryl fluorocarbons at room temperature and alkyl fluorocarbons under more forcing conditions.
Rhodium‐Catalyzed Enantioselective Hydrogenation of (E)‐Enol Acetate Acids
Authors: Arena Giada , Barreca Giuseppe , Carcone Luca , Cini Elena , Marras Giovanni , Nedden Hans G. , Rasparini Marcello , Roseblade Stephen , Russo Adele , Taddei Maurizio , Zanotti‐Gerosa Antonio
Published: February 2013

The novel rhodium complex [Rh(S)‐Phanephos(cod)]‐catalyzed hydrogenation of disubstituted (E)‐enol acetate carboxylic acids is reported. The catalytic cycle works under 30 bar of hydrogen under conventional heating giving different 3‐acetoxy‐2,3‐disubstituted carboxylic acids with ee ≥90%. Hydrogenation occurred also under microwave dielectric heating without eroding the enantioselectivity but improving the overall efficiency of the process. With microwaves, hydrogen pressure and reaction time required for complete hydrogenation dropped to 5 bar and 30 min, respectively. The best performance of this catalyst under microwave irradiation was TON 100, TOF 196 h−1 with ee 99% on a 6‐g scale.
Implications of Agglomeration Economies and Market Access for Firm Growth in Food Manufacturing
Authors: Schmit Todd M. , Hall Jeffrey S.
Published: February 2013

With the persistent changes in technology and increased competition in food manufacturing, it is important to reassess the effects of agglomeration economies and market access on the performance of firms. Using survey data from New York food processors, an ordered logit analysis reveals that firm growth is related to important upstream and downstream market condiations. The clustering of similar manufacturers was found to have important effects on firm revenue growth, with the benefits of firm clustering increasing significantly with the level of local urbanization. For these reasons, policies that promote intra‐industry or cross‐industry collaboration would likely benefit food manufacturers, but these benefits would not be limited to firms in close geographic proximity to one another. Moreover, in rural areas especially, manufacturing firms and community planners need to be aware of possible negative effects of competition from growing concentrations of firms so that these issues can be addressed before local business growth is adversely affected.
Indium Tin Oxide Electrode Modified by a NH2+ Ion Implantation Technique for Determination of Melamine
Authors: Zhang Mingxing , Hu Jingbo
Published: February 2013

The purpose of this study was to develop a novel, reliable and highly sensitive electrochemical method for detection of melamine. 1.0×10−4 M melamine was hydrolyzed to ammeline in 0.5 M H2SO4 at 80 °C for 20 min. Subsequently it was electrochemically detected by cyclic voltammetry (CV) in 0.1 M phosphate buffer solution (pH 7.0) at NH2/ITO electrode. The method detected melamine in the linear range of 1.0×10−10–5.0×10−8 M and the detection limit was 3.0×10−11 M. The method had been successfully applied to the determination of melamine in milk powder and human urine samples.
Voltammetric Determination of Iron(III) in Water
Authors: Lu Min , Compton Richard G.
Published: February 2013

A square wave voltammetric procedure for the determination of trace amounts of Fe(III) was developed at an unmodified edge plane pyrolytic graphite (EPPG) electrode and a screen printed electrode (SPE). This simple procedure was applied to real samples of commercially bottled mineral water. Sensitive results in the micromolar region could be achieved without modification of the electrode. Using the WHO guideline limits for the Fe(III) concentration in drinking water, recovery percentages at an EPPG gave 103 % and 107 %, and 98.6 % and 95.0 % at a SPE for the 5.36 µM (0.3 mg L−1) and 53.6 µM (3.0 mg L−1) additions of Fe(III), respectively.
Discussion on the article ‘Coastal and inland karst morphologies driven by sea level stands: a GIS based method for their evaluation' by Canora F, Fidelibus D and Spilotro G
Authors: Waele Jo De , Parise Mario
Published: February 2013

Comments are presented on the article by Canora et al. (2012) dealing with karst morphologies driven by sea level stands in the Murge plateau of Apulia, southern Italy. Our comments start from cave levels, that are considered in the cited article as a proof of sea level stands. We argue that the presence of sub‐horizontal passages in cave systems is not a sufficient condition for correlating them with hypothetical past sea level stands. Such a correlation must be based upon identification of speleogenetic features within the karst systems, and/or geological field data. The problems encountered when using cave surveys for scientific research, and their low reliability (especially in the case of old surveys) are then treated, since they represent a crucial point in the paper object of this discussion. Eventually, we present some final consideration on cave levels and terraces, and on the specific case study, pointing out once again to the need in including geological field data to correctly find a correspondance between flat landforms and sea level fluctuations. Our main conclusion is that field data and information on speleogenesis of the underground karst landforms cannot be disregarded in a study that claims to deal with the influence of sea‐level changes on caves. Copyright © 2013 John Wiley & Sons, Ltd.
Decadal volcanic deformation in the Central Andes Volcanic Zone revealed by InSAR time series
Authors: Henderson S. T. , Pritchard M. E.
Published: February 2013

Decadal trends of volcanic deformation in the Central Andes Volcanic Zone (CVZ) are identified with Interferometric Synthetic Aperture Radar (InSAR) stacks and time series velocity maps covering an area 19°S–27°S and 66°W–69°W. We combine over 750 ERS and Envisat interferograms from two descending and three ascending tracks. These tracks cover 100,000 km 2 and span 1992–2011. Our analysis extends observations at Cerro Blanco, Uturuncu, and Lazufre volcanic centers and uncovers two previously undocumented deformation centers: Cerro Overo in Northern Chile and Putana Volcano in Southwest Bolivia. Cerro Overo exhibits a transition from steady −0.4 cm/yr deflation to 0.5 cm/yr inflation over several years. Putana Volcano underwent a short‐lived episode of uplift between 13 September 2009 and 31 January 2010, with a maximum uplift of 4.0 cm. Cerro Blanco continues −1.0 cm/yr deflation since 1995. Uplift at Lazufre began between 1997 and 2000 and has gradually accelerated to 3.5 cm/yr since 2005. Uturuncu volcano continues 1.0 cm/yr monotonic uplift since 1992 and shows evidence for a broad moat of subsidence surrounding the uplifting region. Four of the nine deformation events in the CVZ are not obviously associated with a particular volcanic edifice. Furthermore, there is significant spatial and temporal variability of these deformation events within a small geographic area.
Influence of rotation on the metal rain in a Hadean magma ocean
Authors: Moeller A. , Hansen U.
Published: February 2013

Today, it is widely accepted that during its early evolution, the Earth experienced a magma ocean that covered most of its surface. The separation of metal from silicate was much facilitated in the environment of such a magma ocean. The differentiation mechanism is known as the “metal‒rain scenario”. Our study will focus on the settling dynamics of these metal droplets. Because of the low viscosity of molten silicate and a higher rotation period of the Earth at that time the rotation has a potentially strong influence on the dynamics of the magma ocean. We use numerical 3D fluid simulations to analyze the combined effects of strong rotation and convection on the settling of the iron droplets. We show that the influence of rotation on the settling depends on the latitude. At the poles, the influence of rotation is only marginal. At the equator, three different scenarios can be distinguished. First, at low rotation rates, the particles form a dense layer at the bottom. Second, for strong rotation, the particles stay mostly suspended and layers form in the temperature field. Third, at higher rotation rates, the particles form a ribbon‒like structure in the middle of the box. The influence of rotation on the iron droplets may lead to a scenario where part of the iron is kept in the mantle instead of transported to the core. This would have a strong influence on the later states of the differentiation process and the amount of siderophile elements in the mantle.
Irreversible mass loss of Canadian Arctic Archipelago glaciers
Authors: Lenaerts Jan T. M. , van Angelen Jan H. , van den Broeke Michiel R. , Gardner Alex S. , Wouters Bert , van Meijgaard Erik
Published: February 2013

The Canadian Arctic Archipelago (CAA) contains the largest volume of glacier ice on Earth outside of Antarctica and Greenland. In the absence of significant calving, CAA glacier mass balance is governed by the difference between surface snow accumulation and meltwater runoff—surface mass balance. Here we use a coupled atmosphere/snow model to simulate present‐day and 21st century CAA glacier surface mass balance. Through comparison with Gravity Recovery and Climate Experiment mass anomalies and in situ observations, we show that the model is capable of representing present‐day CAA glacier mass loss, as well as the dynamics of the seasonal snow cover on the CAA tundra. Next, we force this model until 2100 with a moderate climate warming scenario (AR5 RCP4.5). We show that enhanced meltwater runoff from CAA glaciers is not sufficiently compensated by increased snowfall. Extrapolation of these results toward an AR5 multimodel ensemble results in sustained 21st century CAA glacier mass loss in the vast majority (>99%) of the ~7000 temperature realizations.
Signature of fault zone deformation in near‐surface soil visible in shear wave seismic reflections
Authors: Ghose Ranajit , Carvalho Joao , Loureiro Afonso
Published: February 2013

Small‐throw seismogenic fault segments hidden in the Holocene sediments are crucial but difficult targets in seismic exploration. We report here the detection of the deformation pattern and a concealed fault segment in the unconsolidated sediments at Vila Franca Xira, Portugal, through identification in shear wave reflection data of multiple signatures of ductile deformation associated with faulting. We find step‐like changes in the stacking velocity along a shallow subsoil layer boundary, indicating synsedimentary faulting. We also recognize a consistent distortion in the moveout of the reflection events in the raw shear wave data. Synthetic modeling of seismic data helps in interpreting these observations and identifying backscattered energy from a steeply dipping shallow fault zone. Prior to this finding, there was no evidence for Holocene activity of this fault, although the fault is considered to be the most probable source for the disastrous 1531 earthquake.
Near real‐time monitoring of volcanic surface deformation from GPS measurements at Long Valley Caldera, California
Authors: Ji Kang Hyeun , Herring Thomas A. , Llenos Andrea L.
Published: February 2013

Long Valley Caldera in eastern California is an active volcanic area and has shown continued unrest in the last three decades. We have monitored surface deformation from Global Positioning System (GPS) data by using a projection method that we call Targeted Projection Operator (TPO). TPO projects residual time series with secular rates and periodic terms removed onto a predefined spatial pattern. We used the 2009–2010 slow deflation as a target spatial pattern. The resulting TPO time series shows a detailed deformation history including the 2007–2009 inflation, the 2009–2010 deflation, and a recent inflation that started in late‐2011 and is continuing at the present time (November 2012). The recent inflation event is about four times faster than the previous 2007–2009 event. A Mogi source of the recent event is located beneath the resurgent dome at about 6.6 km depth at a rate of 0.009 km3/yr volume change. TPO is simple and fast and can provide a near real‐time continuous monitoring tool without directly looking at all the data from many GPS sites in this potentially eruptive volcanic system.
Variations of OH radical in an urban plume inferred from NO2 column measurements
Authors: Valin L. C. , Russell A. R. , Cohen R. C.
Published: February 2013

The evolution of atmospheric composition downwind of a city depends strongly on the concentration of OH within the plume. We use space‐based observations of NO2, a molecule that affects both the sources and sinks of OH, to examine the functional dependence of OH concentration on the speed of the wind over Riyadh, Saudi Arabia. These observations illustrate the nonlinear dependence of the OH concentration on NO2 and on the rate of atmospheric mixing. We derive a range of NOx lifetimes of 5.5–8.0 h, lifetimes that correspond to an effective plume‐averaged OH concentration of 7.6 × 106 molecules cm–3 at fast (26 km h–1) and 5.2 × 106 molecules cm–3 at slow (4 km h–1) wind speeds.
The effect of domain size on the relationship between circulation type classifications and surface climate
Authors: Beck Christoph , Philipp Andreas , Streicher Florian
Published: February 2013

The ability of circulation type classifications (CTCs) to resolve surface climatic and environmental variables is essential with respect to their application in synoptic climatological applications. This ‘synoptic skill’ depends on several factors including inherent properties of classification methods but as well varying boundary conditions. In this contribution the relevance of the size of the spatial domain for which CTCs are derived is investigated. To this end varying automated CTCs are applied to daily gridded sea level pressure data for 1950–2010 and in each case eight spatial domains of varying size centred around 44 locations spread over the greater north Atlantic European region. For the resulting more than 7000 CTCs the synoptic skill for daily temperature and precipitation taken from the E‐OBS v4.0 data set has been estimated using varying evaluation metrics. Resulting values of evaluation metrics aggregated according to varying domain sizes reveal a distinct influence of the size of the domain on the synoptic skill of CTCs. In general highest skill appears to be achieved for domain sizes with a horizontal dimension of roughly 1300–1800 km (in west–east direction) thus covering most frequent size ranges of synoptic scale systems. However, optimal domain sizes tend to be smaller for precipitation (compared to temperature) in summer (compared to winter) and in more continental regions (compared to more oceanic regions). Distinct deviations from the overall finding of relatively small optimal domains emerge for temperatures above/below certain thresholds for which in certain locations and seasons continental scale domains yield highest synoptic skill. Finally the comparison of varying CTCs concerning the effect of the domain size for synoptic skill shows marked differences between methods and moreover clearly elucidates that differences in synoptic skill that can be attributed to varying domain sizes reach comparable magnitude than those related to differing methods.