bluuebunny/crossref_metadata_2025 huggingface dataset:
Grapevine (Vitis vinifera L.) varietal assortment and evolution in the Marche region (central Italy)
Authors: Crespan Manna , Migliaro Daniele , Larger Simone , Pindo Massimo , Palmisano Massimo , Manni Alvise , Manni Elisa , Polidori Enzo , Sbaffi Francesco , Silvestri Quintilio , Silvestroni Oriana , Velasco Riccardo , Virgili Settimio , Camilli Giuseppe
Published: July 2021

Italy is one of the richest countries in terms of grapevine varietal assortment, and the Marche region in central Italy has an ancient winegrowing tradition. Increasing interest in autochthonous grapevine varieties prompted efforts to recover and identify local minor germplasm also in this region, and to search for pedigree relationships and determine the evolution of varietal assortment. In the present study this was done using nuclear and chloroplast microsatellite markers and SNP markers from the Vitis18kSNP chip. Eighteen new genotypes were found, of which seventeen belonged to well-known, less known and even unknown vines found to be specific to the Marche region. The rearranged pedigree highlighted the complex intertwining relationships between Marche varieties. Second-degree relationships were also derived. Some minor Marche varieties have increased the number of parent-offspring related members of Garganega, Sangiovese, Crepolino/Visparola and Sciaccarello, which are varieties already recognised as founders or recurrent parents of many Italian cultivars. Crepolino/Visparola was shown to be a key variety in the evolution of the Marche varietal assortment, having played the role of parent and grandparent, as explained by the presence of this genotype in the region in ancient times. Surprisingly, Semidano, a well-known Sardinian variety, played a clear role as parent or grandparent of three minor Marche varieties, testifying to its presence in central Italy in ancient times. Incrocio Bruni 54 was confirmed as an offspring of Sauvignon and Verdicchio, as declared by the breeder. The parentage of Lacrima was completed: this variety was found to be a spontaneous cross between Nera Rada and Aleatico.A dendrogram of genetic similarity clearly resembled the groups defined with the pedigree reconstruction and it gave an indication of the genetic similarity of the varieties excluded from the strictest parentage links.
Peningkatan Produktivitas Melalui Penerapan 5S di IKM Kulit di Sleman, Yogyakarta
Authors:   Teknik Industri, Universitas Islam Indonesia, Miranda Suci , Kusrini Elisa ,   Teknik Industri, Universitas Islam Indonesia
Published: July 2021

Small and Medium Enterprise (SME) called MARS Genuine Leather is one of the SMEs under the guidance of the Department of Industry and Trade (Disperindag) in the Sleman region, Yogyakarta. In 2018, MARS and 10 other SMEs in Sleman and Bantul Regency have involved in research with the Department of Industrial Engineering at the Islamic University of Indonesia regarding supply chain performance analysis using the Supply Chain Operation Reference (SCOR) Model. The results showed that MARS had the lowest supply chain value among the 5 SMEs in the Sleman region. Continuing the results of the research, improvements were made through Community Service activities regarding the implementation of 5S in MARS. the Department of Industry and Trade (Disperindag) of Sleman has provided several pieces of training on the implementation of 5S for SME owners. However, this training has not been applied directly to each IKM. Therefore, this service activity aims to provide hands-on training on the implementation of 5S at IKM MARS as well as one of the improvements that can be made to the results of previous supply chain performance analysis research. The results of this service are in the form of direct training guidance at IKM, videos of the first 3S implementation (Seiri, Seiso, Seiton), and a checklist form that can be used by IKM as an internal audit. The 5S knowledge and skills that have been applied in MARS are expected to help the enterprise to reduce waste as well as increase productivity in the future.
CRISPR Cas9 Tip of an Iceberg: It’s Potential in Genome Editing and Many More
Authors: Ahmad Jalal , Siddique Nayyer
Published: July 2021

Clustered regularly interspaced short palindromic repeats or CRISPR, one of the major technological tools from nature's toolbox, has revolutionized the scientific world with its potential use in humans and plants. CRISPR Cas9 was first known as an adaptive immune system of bacteria. It is a system that cleaves foreign DNA. It has been exploited to be used as a genome editing tool for correcting genetic diseases in humans, for plants to create stress-resistant plants, and for a variety of different purposes. This review provides a basic overview of its applications in different areas of biological research. It has immense potential for a variety of researches, but it's still a mystery for science. It feels like scientists just know a tip of an iceberg.
Development and Performance Evaluation of a Two-Wheel Tractor Mounted Conservation Tillage Trencher for Sugarcane
Authors: Tabriz Sayed Shams , Awal Mohammad Abdul , kader Mohammad Abdul , Hossen Mohammad Sanowar , Ali Md. Rostom , Hossain Md. Ayub
Published: July 2021

An efficient design of conservation tillage trencher (CTT) saves time, natural resources, and conserves soil health by avoiding vigorous soil disturbance of tillage operations. A two-wheel tractor operated CTT has constructed with modified rotary shafts, toolbar frames, depth control bars, bed shapers and chisel ploughs for conservation tillage operation of sugarcane plantation. The performance evaluation of developed CTT was tested for comparing the suitability with small-scale farmer’s practice (SFP) and large farm practice (LFP). Finally, the CTT is applied for preparing sugarcane farmland in different conservation tillage methods of i) bed cum trenching (BT), ii) zero-tillage trenching (ZT) and iii) strip-tillage (ST). The performance of effective field capacities of CTT were 0.14 ha h-1, 0.12 ha h-1 and 0.14 ha h-1 for BT, ZT and ST, respectively. Developed CTT saved time 80% and 26-37% over SFP and LFP, and required 96% and 26-36% less labour than SFP and LFP, respectively. Conservation tillage required 7-10 l ha-1diesel whereas SFP and LFP required 25 l ha-1and 65 l ha-1, which reduced CO2 emission by 60-72% and 85-89% compared to SFP and LFP, respectively. Ultimately, newly developed CTT saved sugarcane land preparation costs by 86% to 90% compared to conventional tillage systems.
Intermixing the OPN1LW and OPN1MW Genes Disrupts the Exonic Splicing Code Causing an Array of Vision Disorders
Authors: Neitz Maureen , Neitz Jay
Published: July 2021

The first step in seeing is light absorption by photopigment molecules expressed in the photore-ceptors of the retina. There are two types of photoreceptors in the human retina that are respon-sible for image formation, rods and cones. Except at very low light levels when rods are active, all vision is based on cones. Cones mediate high acuity vision and color vision. Furthermore, they are critically important in the visual feedback mechanism that regulates refractive development of the eye during childhood. The human retina contains a mosaic of three cone types, short-wavelength (S), long-wavelength (L) and middle-wavelength (M); however, the vast major-ity (~94%) are L and M cones. The OPN1LW and OPN1MW genes, located on the X-chromosome at Xq28, encode the protein component of the light-sensitive photopigments. Here we review mechanism by which splicing defects in these genes cause vision disorders.
THE USE AND MAINTENANCE OF HORSES IN THE ASPECT OF NATURAL TRAINING METHODS
Authors:   Institute of Animal Science and Fisheries, Siedlce University of Natural Sciences and Humanities, Poland, RATAJCZAK Angelika , DANIELEWICZ Agata ,   Institute of Animal Science and Fisheries, Siedlce University of Natural Sciences and Humanities, Poland, PLUTA Michał ,   Department of Horse Breeding and Use, University of Life Sciences in Lublin, Poland
Published: July 2021

As a result of evolution, humanity transitioned from a nomadic to a sedentary way of life, from hunting and gathering to crop production and animal husbandry. Domestication involved capturing wild horses and adapting them to the conditions in which they were raised by humans. This resulted in a change in the treatment of horses and the perception of their emotional needs. The focus shifted to building relationships with the horse, understanding it, and treating it as a rational being. Currently, horses are seen as one of the most intelligent animals ‘cooperating’ with people. In this study, 62 horses at four equestrian centres were examined. The horses included mares, stallions and geldings between the ages of 3 and 26 years, belonging to eight breeds: Arabian, Malopolski, Hucul, Polish Half-Bred, Silesian, Polish Coldblood, Shetland pony, and Haflinger. The analysis of forms of horse training indicated that all centres used classical training methods for 100% of their horses. The trainers declared interest in natural methods, but as support for classical training. Natural methods of working with horses were applied at centres 2 and 3, where horses were ridden both for recreation and for sport. This type of training was not observed at centre 1, where horses were used only for recreational riding, or at centre 4, which dealt mainly in breeding and training of race horses. Horses at centre 3 and most of those at centre 2 took part in in Parelli’s Seven Games, Join-Up, and desensitization to unknown objects, and imprinting of foals was practiced. This indicates that horse trainers are currently applying natural methods, but are not completely giving up classical training. A study was carried out to investigate the approach of contemporary horse breeders to forms of housing and use with respect to their interest in foal imprinting, natural horsemanship, Join-Up, and desensitization to unknown objects.
Analysis of Competitive Strategies of Tourism Industry in the Midst of Covid-19 Pandemic: A Case from Philippines
Authors: De Jesus Fhrizz S. , Grace E. Co Annalene , Zolete Czarina P.
Published: July 2021

This study described the Analysis of Competitive Strategies and Challenges of Tourism Industry in the Midst of Covid-19 Pandemic and provide recommendations. Specifically, it looked into the challenges and recommendations of the owners of operational tourist spots in the selected municipalities in Nueva Ecija which are Bongabon and Laur and analyzed how comparative strategies contribute to the challenges and recommendations of the owners of operational tourist spots. This study used the descriptive-evaluative method and total enumeration for its sampling procedure. As to its findings, to improve the tourism operation of the respondents amidst the Covid-19 pandemic, the result shows that the respondents “always” used competitive strategies in their businesses. Based on the result, the focus-strategy which is one of the elements of comparative strategies was ranked number one, it means that the owners of operational tourism spots wanted to take all the challenges they were encountered amidst pandemic, it is not a barrier for them to stop their businesses that is why they want to know in a market due to their pleasing tourist spots compared to its competitors and they have recommendations on how to innovate and improve their operational tourist spots.
Is It Possible to Prevent Radicalism through Women's Participation in STEM (Science, Technology, Engineering, and Mathematics) Education?: Challenges and Opportunities
Authors: Imaduddin Muhamad
Published: July 2021

Women and education as an effort to prevent radicalism are connected. If the international community tries to engage education as part of a strategy to reduce terrorism, it should be necessary to consider the content of education. One of the SDGs mandates in “equality” is the importance of women to be involved in mastering STEM. This study reveals how the challenges and opportunities for women's relationships and participation in STEM education can make it possible to prevent the emergence of radicalism. This was carried out by exploring several kinds of literature related to the level of women's participation and the usefulness of STEM education. The role of women is shown by their participation as learners, educators, and directly involved in the STEM industry as a workforce. As an educator, women's participation occupies a much better position than workforces. STEM content can be integrated with radicalism issues to be resolved in the classroom to practice critical thinking skills. Women as STEM workers face obstacles that have nothing to do with their abilities, such as stereotyping, discrimination, violence, and abuse. Religious education integrated with STEM education provides an opportunity to reduce radicalism values with women taking part in it.
Desacralization of Marriage in the Islamic Community of Javanese Farmers
Authors: Sardjuningsih Sardjuningsih
Published: July 2021

Field research with a phenomenological approach, in the District of Kabuh-Jombang. The barren rural socio-geographical setting makes tradition basics a reference and measure of norms of action. The uniqueness of this study with previous research is the process of reducing the sacredness of marriage by placing the status of Widower or Widow better than the status of an old spinster or old age. Research with a Phenomenological approach with Robert Merton's Structural-Functional analysis knife rests on deep interview techniques of 20 informants consisting of couples who experience young and divorced couples, families, and community leaders. produce conclusions that the tradition of underage marriage is a social fact, a habit that still continues to this day, constructed with noble and sacred meaning. In the social process the Nobleness of meaning is not supported by other social facts, that being a widower or widow is better than being an old woman or old woman. This puts divorce better than maintaining marriage. This pragmatic outlook is contrary to the ideal ideals of a sacred marriage. The result of a complex divorce is a negative new social fact that is neglecting the rights of children to be paid by their parents. This negative social fact is due to the dysfunctional social control and social structure of the process of adaptation to change.
Gender Equality on Nahdlatul Ulama and Muhammadiyah Perspective
Authors: Abidin Ahmad Zainal , Ratnawati Dewi , Taufiqurrahim Taufiqurrohim , Aziz Thoriqul
Published: July 2021

Factors related to the discrimination of women's rights include religious perspectives that are contaminated by cultural patriarchy, race, social strata, gender identity, sexual orientation, age, and health. Liberation of women's rights can be realized by Islamic organizations which are free from the negative influence of patriarchal culture. These organizations are Nahdatul Ulama 'and Muhammadiyah. The focus of the discussion includes the gender perspective of Nahdatul Ulama and Muhammadiyah. it also want to trace the gender equality perspective of Nahdatul Ulama' and Muhammadiyah. The method used by the writer is in the form of library research. Sources of data are taken from relevant theme raised by the author. The results of research are giving freedom for women to realize their rights and potential both in the public sector and domestic sector. 
Gembyangan Waranggana: The Process of Abjection toward Warangganas and Langen Tayub Tradition.
Authors: Mujahidah Affaf
Published: July 2021

The concept of representation of Dewi Sri manifested in the Langen Tayub performance. However, as the massive development in Javanese society, the image of warangganas has gradually derogated. Even waranggana has been synonymous with prostitute, being a waranggana is not similar to be a sexual worker. There are many requirements of being a waranggana. Not only must able to sing obligatory gendhings, a waranggana is required to be a good dancer. Therefore, a waranggana training system was established in Ngrajek, Sambirejo, Tanjunganom, Nganjuk regency, East Java. The procession of graduation from this training has been an annual tourism agenda of Nganjuk regency, called gembyangan waranggana. The existence of training system for waranggana has been an antithesis of pejorative image of warangganas. Therefore, this paper aims to analyze on the existence of waranggana training system in Nganjuk. Refers to Kristeva idea of abjection of women role, this paper will focus on how the negative perception of warangganas has been formulated. Moreover, the discussion of government policies for managing this training system will be another highlight. The first chapter will be an introduction which represented by the history of gembyangan waranggana. The second chapter will explain the process being a good waranggana and skills have to be mastered. Then will continue by the social condition of waranggana and the society’s perception toward them. All chapters will be wrapped up by the last chapter, discussion.
РАСПРОСТРАНЕНИЕ ВАРИАНТОВ ВИРУСА SARS-COV-2, ВЫЗЫВАЮЩИХ ОЗАБОЧЕННОСТЬ (VOC) И ИНТЕРЕС (VOI) НА ОСНОВЕ КОЛИЧЕСТВА ИХ ГЕНОМОВ, ДЕПОНИРОВАННЫХ В БАЗУ ДАННЫХ GISAID ЗА НЕДЕЛЮ с 03.07.2021 г. по 09.07.2021 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: July 2021

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с 03.07.2021 г. по 09.07.2021 г.
EFFECT OF SCREEN HOUSE MODIFICATION AT FLOWER BUD STADIA ON FLOWER QUALITY OF CHRYSANTHEMUM AT MEDIUM UPLAND ELEVATION
Authors: Shintiavira Herni , Sulistyaningsih Endang , Purwantoro Aziz , Wulandari Rani Agustina
Published: July 2021

Higher temperature and light intensity at the medium upland elevation decrease the number of blooming flowers, flower diameter, and red color flower intensity of Chrysanthemum morifoliumcompared to that at the high upland elevation. The environmental modification was needed during the flower development phase to improve the quality of chrysantheum at a medium upland elevation. The study aimed to find the suitable screen house environmental modification for increasing the chrysanthemum quality at the medium upland elevation. The study consisted of two factors. First, environmental modification of a screen house, such as (1) control, (2) the addition of shading net on the rooftop of the screen house, (3) the addition of a misting system in the screen house, and (4) the addition of a combination of shading net on the rooftop and misting system in the screen house. Second, the chrysanthemum varieties, including (1) Yastayuki (white flower), (2) Arosuka Pelangi (yellow flower), and (3) Socakawani (red flower). Experiments were arranged in a completely randomized design with three replications. Data were analyzed by combined ANOVA. The results showed that either the addition of a shading net or misting system reduced the number of flower buds growing. The competition among flower buds was found to be reduced by decreasing the number of flower buds.  Consequently, the number and diameter of the blooming flower increased. The addition of a shading net on top of the screen house was the most suitable environmental modification to increase the chrysanthemum quality at the medium upland elevation.
RESISTANT LEVEL OF SOYBEAN GERMPLASM AGAINST POD SUCKING BUGS (Riptortus spp.)
Authors: Herlina Lina , Istiaji Bonjok , Koswanudin Dodin , Sutoro Sutoro
Published: July 2021

Increasing productivity of soybean has often been constrained by pod sucking bugs (Riptortus spp.) which caused a serious damage  and yield losses up to 80%. Breeding for obtaining soybean variety resistant to pod suckers needs the availability of soybean germplasm resistant to the pest. The study aimed to obtain a candidate for soybean variety resistant to Riptortus spp. through the selection of 100 accessions of soybean. The study included the preparation of test plants and test insects, pest infestations, observations, and looking for a practical screening method for pod sucking pests. The experiment used a completely randomized design for two treatments (infested and non-infested Riptortus spp.). Cikuray variety and PI-092734 accession were used as a control. Results showed that there was a very low correlation among variables observed. Twelve soybean accessions showed a resistance to Riptortus spp., i.e. C7301-113AC-POP, Lokal Madiun-3549, Lokal Klungkung, ML.2974, Singgalang, Lokal Jepara, Lokal Jatim, Lokal Trenggalek, Lokal Tulungagung, Lokal Tabanan, Lokal Blitar, and Lokal Kuningan 10. These accessions were more resistant than the popular released variety such as Wilis, Grobogan, Detam 2, and Gepak Ijo. Small seed size was not a major determinant of soybean resistance to pod suckers. The addition of observational components, i.e. probing preference and oviposition, indicated that crop damage was indirectly influenced by the high frequency of probing and oviposition, although its relation to plant tolerant mechanisms still needs further investigation. Indeterminate plant types require further validation as to whether they contribute significantly to plant resistance against pod sucking insects.
Determinants of Agricultural Technology Adoption by Smallholder Farmers in Developing Countries: Perspective and Prospect for Indonesia
Authors: Suprehatin Suprehatin -
Published: July 2021

The role of agricultural technology is important in developing countries. However, in many cases the adoption rate of modern agricultural technology by smallholder farmers is low. Therefore, a better understanding of agricultural technology adoption determinants is important as a major component of agricultural growth. This paper is a review and synthesize of the literature related to potential factors that may constrain or encourage smallholder farmer adoption of new agricultural technologies. The determinant factors influencing smallholder farmer adoption of new technologies in developing countries vary from study to study based on contextual applicability and specific local condition. There are four major typologies of determinant factors are identified to help explain low adoption rates of particular agricultural technology in developing countries which are technology attributes, farmer or farm household characteristics, farm characteristics and institutional factors. Future policy recommendations on adoption decision should consider all those four important factors to provide better understanding of new agricultural technology adoption by smallholder farmers, resulting in improved livelihoods for smallholders.

Keywords: Agricultural, technology, adoption, farmer

 

Abstrak

DETERMINAN ADOPSI TEKNOLOGI PERTANIAN OLEH PETANI KECIL DI NEGARA BERKEMBANG: PERSPEKTIF DAN PROSPEK UNTUK INDONESIA

Peran teknologi pertanian sangat penting di negara berkembang. Meskipun demikian, tingkat adopsi teknologi pertanian baru oleh petani kecil masih rendah. Oleh karena itu, pemahaman terhadap faktor-faktor yang menentukan keputusan petani dalam mengadopsi teknologi sangat penting untuk meningkatkan pertumbuhan sektor pertanian. Tulisan ini adalah hasil sintesis terhadap beberapa literatur ilmiah yang berkaitan dengan faktor penghambat atau pendorong petani kecil dalam mengadopsi teknologi pertanian. Faktor yang memengaruhi petani kecil mengadopsi teknologi pertanian di negara berkembang berbeda antarstudi berdasarkan kebutuhan dan kondisi lokal tertentu. Empat kelompok utama faktor penentu yang dapat menjelaskan rendahnya adopsi teknologi di negara berkembang yaitu atribut teknologi, karakteristik petani, usaha tani, dan faktor kelembagaan. Rekomendasi kebijakan terkait keputusan adopsi teknologi seharusnya mempertimbangkan keempat kelompok faktor tersebut untuk dapat memahami lebih baik adopsi teknologi baru oleh petani kecil guna meningkatkan kesejahteraannya.

Kata kunci: Pertanian, teknologi, adopsi, petani
Manitoba Public Libraries Response to the Early Stages of COVID-19
Authors: Macdonald Kerry , Robert Andrew , Bannerman-Gobeil Breanne , Bee Richard , Chorney Alan , Heinrichs Caralie , Lee Stacey , Murray Kelly , Sucha Melanie
Published: July 2021

Like many libraries across Canada, Manitoba public libraries have grappled with the challenges that COVID-19 has presented. Libraries have struggled to remain operational and offer a high level of service to patrons within the constraint of public health orders, all the while ensuring the safety and employment of their staff. Within the ever-changing environment of COVID-19, the Manitoba Library Association recognized the need to gather information from the library community in order to better position themselves to lend support and in an attempt to bridge information gaps. This article describes a study conducted by the Manitoba Library Association whereby fifty-five Manitoba public libraries were surveyed to identify how they were responding to COVID-19 and what their needs might be. The survey questions were divided into 6 sections (facilities, services, communications, staffing, connecting, wrap-up) and the results provide information and insight into how the Manitoba library community has dealt with the pandemic. More importantly, the results can serve to guide other libraries in decision-making and preparation for a pandemic.
Análisis comparativo del marco legal en salud mental y suicidio en México
Authors: Valdez-Santiago Rosario , Marín-Mendoza Eréndira , Torres-Falcón Marta
Published: July 2021

Objetivo. Analizar el marco legislativo y normativo en salud mental y suicidio en México. Material y métodos. Se rea­lizó un análisis secundario de los principales ordenamientos jurídicos en materia de salud mental y suicidio, vigentes hasta septiembre de 2020, de las 32 entidades de México y del nivel federal. Resultados. Se analizaron 51 documentos. Sólo 14 entidades cuentan con una Ley de Salud Mental y dos estados tienen una Ley de Suicidio. A nivel federal, se definen los li­neamientos de atención de la conducta suicida en las normas técnicas de la Secretaría de Salud. Sin embargo, en las leyes de salud, nacional o estatales, han existido omisiones al respecto. La prevención no se define a profundidad en la mayoría de los documentos analizados. Conclusiones. Es prioritario impulsar leyes integrales de salud mental y conducta suicida armonizadas en el ámbito nacional.
Daños colaterales de la pandemia por Covid-19 en el tamizaje de cáncer de mama
Authors: Villaseñor-Navarro Yolanda , Sollozo-Dupont Isabel
Published: July 2021

No disponible.
MULTIDRUG RESISTANCE OF Klebsiella pneumoniae IN CATS IN BOGOR, INDONESIA
Authors: Ramadhan Juliadi , Safika Safika , Ika Mayasari Ni Luh Putu
Published: July 2021

This study aims to measure the level of antibiotic resistance to Klebsiella pneumoniae isolated from clinical cats in Bogor. Samples were isolated and identified macroscopically, microscopically, and biochemically. Positive isolates were tested for antibiotic sensitivity using the Kirby-Bauer disk diffusion method. The results showed that Klebsiella pneumoniae isolated from sputum and laryngeal swabs of clinic cats in Bogor had experienced Multidrug Resistance (MDR). The highest level of resistance to Klebsiella pneumoniae occurred in the β-lactam group (amphicillin 76%) followed by the tetracycline group (oxytetracycline 72% and tetracycline 68%), then the quinolone group (enrofloxacin 52%), and finally the aminoglycoside group (gentamicin 44%). The results of this study are expected to be taken into consideration in the use of antibiotics for the treatment of cases related to the Klebsiella pneumoniae bacteria.
A Influência da Participação em Jogo On-line na Atitude de Alunos de Curso Presencial de Administração em Relação a Cursos na Modalidade a Distância
Authors: Da Silva Deivson  Aroeira , Moura Luiz Rodrigo Cunha , Higuchi Agnaldo Keiti
Published: July 2021

Vários motivos já conhecidos levam ao descrédito da modalidade EaD e prejudicam seu potencial transformador por meio da universalização da educação. Apesar disso, no caso do ensino da Administração, instituições utilizam jogos on-line, não presenciais, como ferramentas de ensino. Por isso, esse estudo tem como objetivo analisar como a participação em jogo empresarial on-line, promovido por organização do sistema “S”, influencia a atitude de alunos de cursos de graduação em Administração presenciais em relação a cursos EaD. Por meio de pesquisa documental em dados fornecidos por instituição de ensino superior de Minas Gerais, levantaram-se informações que passaram por análise de conteúdo de Bardin, estatísticas de frequência e correlação de Spearman. Os resultados indicam que a participação no jogo on-line contribui para o aprendizado e a formação, porém não influi na atitude dos alunos em relação à  EaD.
COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance
Authors: Simonetti Michele , Zhang Ning , Harbers Luuk , Milia Maria Grazia , Brossa Silvia , Nguyen Thi Thu Huong , Cerruti Francesco , Berrino Enrico , Sapino Anna , Bienko Magda , Sottile Antonino , Ghisetti Valeria , Crosetto Nicola
Published: July 2021

While mass-scale vaccination campaigns are ongoing worldwide, genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to monitor the emergence and global spread of viral variants of concern (VOC). Here, we present a streamlined workflow—COVseq—which can be used to generate highly multiplexed sequencing libraries compatible with Illumina platforms from hundreds of SARS-CoV-2 samples in parallel, in a rapid and cost-effective manner. We benchmarked COVseq against a standard library preparation method (NEBNext) on 29 SARS-CoV-2 positive samples, reaching 95.4% of concordance between single-nucleotide variants detected by both methods. Application of COVseq to 245 additional SARS-CoV-2 positive samples demonstrated the ability of the method to reliably detect emergent VOC as well as its compatibility with downstream phylogenetic analyses. A cost analysis showed that COVseq could be used to sequence thousands of samples at less than 15 USD per sample, including library preparation and sequencing costs. We conclude that COVseq is a versatile and scalable method that is immediately applicable for SARS-CoV-2 genomic surveillance and easily adaptable to other pathogens such as influenza viruses.
The mortality outcomes and survival pattern of patients of Myeloproliferative Neoplasms in Malaysia
Authors: Yap Yee Yee , Sathar Jameela , Law Kian Boon , group MPN registry working
Published: July 2021

Background: The prognostication of myeloproliferative neoplasm (MPN) has always been challenging even in the advent of Janus kinase 2 (JAK2 V617F) molecular studies. The survival pattern of MPN in a developing country such as Malaysia is still undetermined.Materials and Methods: This was a retrospective study using information from 774 patients from the National MPN Registry conducted from the year 2009 to 2015 in Malaysia. Patients with the diagnosis of essential thrombocythaemia (ET), polycythaemia vera (PV), primary myelofibrosis (PMF) and unclassified MPN (MPN-U) were included. Survival data were traced until December 2018. Results: The cohort consisted of 42.0% ET, 41.0% PV, 8.9% PMF and 8.1% MPN-U, with 48.8% Malay, 39.1% Chinese, 7.1% Indian, 5.0% Others. The subtypes analysis revealed that male MPNs was more than female MPNs except in ET. The Chinese ethnicity was associated with the highest incidence of ET. The mortality rate was the highest in PMF followed by MPN-U then PV and ET (p<0.0001). Survival analysis revealed that the overall survival differed significantly according to characteristics such as sex, sub-types, JAK2 V617F mutation, bone marrow fibrosis, presence of splenomegaly, diabetes mellitus, hypertension, and bleeding manifestation. Cox regression analysis identified age, haemoglobin level, sex, and subtype as a significant risk factor for mortality outcome. Conclusion: Patients with ET had the slightly better OS while PMF had the worst OS. This is in conjunction with low haemoglobin, worsening bone marrow fibrosis, splenomegaly, diabetes mellitus, hypertension and bleeding. JAK2 V617F mutation was seemingly resulting in inferior overall survival especially in ET and PMF. The survival outcome of the MPN registry is instrumental for future policy development of effective healthcare in Malaysia.
Validation of an Individualized Home-Made Superficial Brachytherapy Mould Applied for Non-Melanoma Skin Cancer
Authors: Jaberi Ramin , Siavashpour Zahra , akha Naser zare , Gholami Mohammad Hadi , Jafari Fatemeh , Biniyaz Mandana
Published: July 2021

Purpose: This study was conducted to evaluate the effect of a Brachytherapy (BT) customized mold (Condensation silicone elastomer (Protesil TM )) thickness ,on dose distribution pattern in deeper lesions used for nonmelanoma skin cancers (NMSC).Material and Method: MOSFET TM and GAFCHROMIC TM EBT3 film dosimeters were used for the different thicknesses of a Brachytherapy (BT) customized mold (up to 20 mm), skin dose and dose in different depths were evaluated.Result: The received dose to the surface is overestimated by TPS.Skin dose can be reduced from 250 to 150% of prescription dose by increasing mold thickness from 5 mm to 20 mm. There was a 7.7% difference in calculated dose by TPS and measured dose by MOSFET. Film dosimetry data was unreliable. There was a good agreement between film dosimetry, MOSFET detector, and TPS results, in the depth of 5mm<.Conclusion: Any individualized material chosen to use for making the customized surface BT mold should be validated at BT departments. Protesil TM can be selected as feasible material to make any form of superficial molds. For thicker NMSC lesions up to 20 mm using thicker molds up to 20 mm can be. Even for 10 mm lesions, by changing mold thickness from 5 mm to 20 mm, skin dose would reduce. Protesil TM can be used to make an individualized superficial BT mold. By increasing the mold thickness, lesions can be treated without overexposing the skin surface and skin dose reduced by increasing mold thickness. So, superficial BT can be recommended as an appropriate treatment option for NMSC lesions with some consideration.
Hub gene identification and prognostic model establishment for patients with HBV-related hepatocellular carcinoma
Authors: Wang Lianmei , Meng Jing , Qin Shasha , Liang Aihua
Published: July 2021

Hepatocellular carcinoma (HCC) is associated with poor 5-year survival. Chronic infection with hepatitis B virus (HBV) contributes to ~50% of HCC cases. Identification of biomarkers is pivotal for the therapy of HBV-related HCC (HBV–HCC). We downloaded gene-expression profiles from Gene expression omnibus (GEO) datasets with HBV-HCC patients and the corresponding controls. Integration of these differentially expressed genes (DEGs) was achieved with the Robustrankaggreg (RRA) method. DEGs functional analyses and pathway analyses was performed using the Gene ontology (GO) database, and the Kyoto encyclopedia of genes and genomes (KEGG) database respectively. Cyclin-dependent kinase 1 (CDK1), Cyclin B1 (CCNB1), Forkhead box M1 (FOXM1), Aurora kinase A (AURKA), Cyclin B2 (CCNB2), Enhancer of zeste homolog 2 (EZH2), Cell division cycle 20 (CDC20), DNA topoisomerase II alpha (TOP2A), BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B), and ZW10 interactor (ZWINT), were identified as the top-ten hub genes. The expression of hub-genes was verified in the liver cancer-riken, JP project from international cancer genome consortium (ICGC-LIRI-JP), the cancer genome atlas (TCGA) HCC cohort, and Human protein profiles dataset. A four-gene prognostic related model based on the expression of ZWINT, EZH2, FOXM1 and CDK1 were established through Cox regression analysis in ICGC-LIRI-JP project, and verified in TCGA-HCC cohort. Furthermore, a nomogram model based on pathology stage, gender and four-genes prognostic model was built to predict the prognosis for HBV–HCC patients. In conclusion, ZWINT, EZH2, FOXM1 and CDK1 play a pivotal role in HBV-HCC, and are potential therapeutic targets of HBV HCC.
Extension of the TOPSIS Method for Decision-making Problem Under Dual Hesitant Fuzzy Language Environment
Authors: Zhang Nian , Zhou Qin , Wei Guiwu
Published: July 2021

In order to comprehensively and actually describe the evaluation process, the dual hesitant fuzzy linguistic (DHFL) set is introduced in this paper, which includes more decision-making information, such as fuzzy state, hesitant process and language information. Specifically, some basic concepts of DHFL set are illustrated and a new distance measure for DHFL information is proposed, which is suitable for overcoming the irrational traditional methodology upon the general distance measure and basic probability concepts. Then, technique for order preference by similarity to ideal solution (TOPSIS) method is extended in dual hesitant fuzzy language environment, a novel TOPSIS method using the DHFL set is presented. Finally, the sensitivity analysis is performed to verify the feasibility and stability of the developed method, then the advantages of the proposed method are also confirmed by detailed comparative analysis.
Low-Dose Fractionated Irradiation Selectivly Regulate CSPGs and PNNs, Promote Serotonergic Axonal Regeneration
Authors: Zhang Qiang , Xu Jiao , Xiong Xiaoxiao , Zhu Bifeng , Zhu Bo , Xiong Ying , Wang Wei
Published: July 2021

Chondroitin sulphate proteoglycans (CSPGs) are major components to impeding axonal regeneration, condense in the extracellular-matrix to form perineuronal nets (PNNs) which interdigitate with axonal contacts. Each CSPG comprises a core protein with covalently attached chondroitin-sulfate glycosaminoglycan side chains (CS moieties). In the past, the representative treatment for CSPGs were chondroitinase-ABC which destroys all CS moieties. However, recent rodents researches found some CS moieties promote axon regeneration rather than inhibit axon regeneration. Using a canine model of spinal cord injury (SCI), which is a superior translational model for progressing rodent data into clinical practice, we showed that specific sulfation patterns of CS moieties play different role in modulation of axon re-growth. Upregulated CS-A expression occurred at 1-day post-SCI, earlier than CS-C expression which was increased at 14-days post-SCI. CS-A was mainly colocalized with astrocytes but CS-C was upregulated in both astrocytes and neurons/axons. Treatment with low-dose fractionated irradiation (LDI) significantly inhibited the expressions of astrocyte-associated CS-A and CS-A-enriched PNNs, but no inhibitory effect on CS-C and CS-C-enriched PNNs. There was a positive correlation between a reduction of CS-A-enriched PNNs and an increase of serotonergic (5-hydroxytryptamine, 5-HT) axonal sprouting. Increased serotonergic axon sprouting proximal to the lesion accompanied 5HT receptor up regulation following LDI treatment. Furthermore, LDI treatment promoted hindlimb motor function recovery following SCI. Taken together, our findings show that specific sulfation patterns of CS moieties and CSPG-enriched PNNs involved in carrying instructions for regulating axonal regeneration and that LDI treatment may be an efficacious strategy for treating SCI.
Development of a Korean Version of Simple, Intuitive Descriptions for Clinical Use of the Generic Functioning Domains in the ICD-11 Chapter V
Authors: Kim Hyun-Jin , Cho Kyeyeob , Kim Jiin , Koo Mi Jung , Yu Jeonga , Kim Hogene , Kwon Ilho , Kim Wanho
Published: July 2021

Background: The World Health Organization recommends the International Classification of Functioning, Disability, and Health (ICF) as a framework for collecting comprehensive information about functioning and disability. However, the utility of the ICF is limited by some inconsistencies in the understanding of the ICF categories. Simple, intuitive descriptions (SIDs) highlight the core concepts of the ICF category definitions in user-friendly languages and enhance the utility of the ICF for routine clinical practice. Currently, the 10th revision of the International Classification of Disease (ICD-10) is being universally used for mortality and disease-related data and as a major indicator of health status in South Korea and worldwide. However, the 11th revision (ICD-11) was developed in 2018 with the addition of Chapter V which reflects functioning properties and better explains the association between functioning and disease. We aimed to develop a Korean version of SIDs for clinical use of the generic functioning domains in the ICD-11 Chapter V.Methods: The initial Korean SID version proposal for the ICF Generic-30 set was translated following the Italian version. For the remaining 17 codes in the generic functioning domains were developed using the original ICF descriptions; the WHO Disability Assessment Schedule; Model Disability Survey; Korean Classification of Functioning, Disability, and Health; and a previous Japanese study. Multistage consensus virtual (Zoom) conferences were held in October 2020 in Korean to develop the SIDs. The final proposal for the Korean version of the SIDs was selected through three rounds of voting. Results: This study demonstrated a total of 47 codes of generic functioning domains in the ICD-11 Chapter V. From vote A, 20 of the 47 items were selected; from vote B, 23 of the remaining 27 items were selected; and the remaining four items were ultimately selected from the final vote. All experts agreed to the final SID proposal. Conclusions: This is the first study in South Korea to attempt the development of SIDs for ICD-11 Chapter V. Therefore, the findings of this study could be used broadly when ICD-11 is adopted for use in Korean clinical settings.
Wideband Hybrid Precoding Techniques for THz Massive MIMO in 6G Indoor Network Deployment
Authors: P Jeyakumar , V Vishnu , S Srinitha , P Muthuchuchidambaranathan , Ramesh Arvind
Published: July 2021

Terahertz (THz) communication is becoming an up-and-coming technology for the future 6G networks as it provides an ultra-wide bandwidth.Appropriate channel models and precoding techniques are essential for supporting the desired coverage and mainly to resolve the severe path loss in THz signals. Initially, the Sub-THz channel (140 GHz) impulse response by using NYUSIM Channel Simulator for 6G indoor office scenario is investigated in this work. The highlight is on Large scale and Small scale parameters like propagation delay and path loss, antenna array gain, etc. The beam split effect is a critical challenge of THz wideband communication.Therefore We have proposed three different THz precoding methodologies like the hybrid precoding, analog beamforming, and the delay-phase precoding to address this challenge. We then extensively investigate its diverse number of time delayers, varying number of antenna elements, and comparison with frequency - mmWave and Sub-THz have been discussed. Finally, the proposed delay-phase precoding techniques outperforms the other precoding techniques with 97% of optimal precoding. So, this an efficient approach for implementing the future indoor communication network deployment for 6G.
Raabin-WBC: a large free access dataset of white blood cells from normal peripheral blood
Authors: Kouzehkanan Zahra Mousavi , Saghari Sepehr , Tavakoli Eslam , Rostami Peyman , Abaszadeh Mohammadjavad , Mirzadeh Farzaneh , Satlsar Esmaeil Shahabi , Gheidishahran Maryam , Gorgi Fatemeh , Mohammadi Saeed , Hosseini Reshad
Published: July 2021

Accurate and early detection of peripheral white blood cell anomalies plays a crucial role in the evaluation of an individual's well-being. The emergence of new technologies such as artificial intelligence can be very effective in achieving this. In this regard, most of the state-of-the-art methods use deep neural networks. Data can significantly influence the performance and generalization power of machine learning approaches, especially deep neural networks. To that end, we collected a large free available dataset of white blood cells from normal peripheral blood samples called Raabin-WBC. Our dataset contains about 40000 white blood cells and artifacts (color spots). To reassure correct data, a significant number of cells were labeled by two experts, and the ground truth of nucleus and cytoplasm were extracted by experts for some cells (about 1145), as well. To provide the necessary diversity, various smears have been imaged. Hence, two different cameras and two different microscopes were used. The Raabin-WBC dataset can be used for different machine learning tasks such as classification, detection, segmentation, and localization. We also did some primary deep learning experiments on Raabin-WBC, and we showed how the generalization power of machine learning methods, especially deep neural networks, was affected by the mentioned diversity.
Diagnostic Performance of CMR, SPECT, and PET Imagings for the Detection of Cardiac Amyloidosis: A Meta-Analysis
Authors: Wu Zhaoye , Yu Chunjing
Published: July 2021

Background: Noninvasive myocardial imaging modalities, such as cardiac magnetic resonance (CMR), single photon emission computed tomography (SPECT), and Positron emission tomography (PET), are well-established and extensively used to detect cardiac amyloid (CA). The purpose of this study is to directly compare CMR, SPECT, and PET scans in the diagnosis of CA, and to provide evidence for further scientific research and clinical decision-making.Methods: PubMed, Embase, and Cochrane Library were searched. Studies used CMR, SPECT and/or PET for the diagnosis of CA were included. Pooled sensitivity, specificity, positive and negative likelihood ratio (LR), diagnostic odds ratio (DOR), their respective 95% confidence intervals (CIs) and the area under the summary receiver operating characteristic (SROC) curve (AUC) were calculated. Quality assessment of included studies was conducted.Results: A total of 31 articles were identified for inclusion in this meta-analysis. The pooled sensitivities of CMR, SPECT and PET was 0.84, 0.98 and 0.78, respectively. Their respective overall specificities were 0.87, 0.92 and 0.83. Subgroup analysis demonstrated that 99mTc-HMDP manifested the highest sensitivity (0.99). 99mTc-PYP had the highest specificity (0.95). The AUC values of 99mTc-DPD, 99mTc-PYP, 99mTc-HMDP were 0.89, 0.99, and 0.99, respectively. PET scan with 11C-PIB demonstrated a pooled sensitivity of 0.91 and specificity of 0.97 with an AUC value of 0.98.Conclusion: Our meta-analysis reveals that SEPCT scans present better diagnostic performance for the identification of CA as compared with other two modalities.
Transmission type Dual-frequency Vortex Beams Generator for Multiple OAM Modes
Authors: Zhang L. , Li J.
Published: July 2021

We design a transmission-type metasurface to generate terahertz dual-frequency orbital angular momentum (OAM) vortex beams with different topological charges (l = 1, l = 2) at frequency of 0.81THz and 1.63THz. By adding a deflection factor, the proposed metasurface produces a OAM vortex beam with a preset tilted direction at two frequencies. By utilizing a complex convolution operation, we can achieve two symmetric tilted beams with different topological charges (l = 1, l=-1) at two frequencies on the same metasurface. These OAM vortex beams can effectively improve communication system capacity, and have potential applications in terahertz communication.