bluuebunny/crossref_metadata_2025 huggingface dataset:
Perisellar tumor coexisting with unruptured cerebral aneurysm: single-stage or staged surgery?
Authors: Wan Xi Chen , Chen Yu Xing , Wu Jie , Chen Shan Si , Tang Bin , Hong Tao , Wu Xiao
Published: March 2023

Objective
The coexistence of perisellar tumors and intracranial aneurysms was previously considered a rare phenomenon. In this study, we introduce our experience with surgical strategies for the treatment of such coexisting pathologies.
Methods
This retrospective study reviews the medical records and intraoperative videos of patients with coexisting pathologies of perisellar tumors and aneurysms from Nov 2017 to Oct 2022.
Results
Our study involved 20 patients, including 9 males and 11 females, with an average age of 53 years. All tumors were completely resected through the endoscopic endonasal approach (EEA) with the exception of 2 asymptomatic pituitary microadenomas with aneurysms in the internal carotid artery (ICA) C1 and C4 segments; for the latter, conservative management was chosen. Thirteen patients chose tumor resection first through the EEA with embolization or aneurysm conservation. Three patients selected the single-stage EEA, including one with a type of MP trigeminal schwannoma with an anterior communicating aneurysm, one with a pleomorphic xanthoastrocytoma with a left ICA paraclinoid aneurysm, and one with a recurrent pituitary adenoma with a right ICA paraclinoid aneurysm. In addition, there were 2 cases in which daughter aneurysms formed after embolization and before tumor resection. Of those, one patient who chose to treat the aneurysm conservatively experienced aneurysm rupture during the follow-up period. No CSF rhinorrhea, severe intracranial infection or surgical-related hemorrhage were found in any of the patients.
Conclusion
Staged surgery or conservative treatment for aneurysms can be considered a safe and effective strategy for the treatment of coexisting pathologies. It is necessary to decide the sequence of staged surgery according to whether the tumor causes obvious neurological symptoms or aneurysms with small processes. However, in very selected cases, the single-stage EEA can be used as part of a comprehensive treatment for such coexisting pathologies.
Ameliorating Prediabetes Symptoms via Aerobic Exercise Combined with Green Coffee and Chlorogenic Acid Intake by Targeting MondoA-TXNIP/ARRDC4-GLUT4 Axis inHigh Fat Diet-Induced Prediabetic Mice
Authors: Sadeghian-Renani Nahid , Marandi Sayyed Mohammad , Reisi Jalil , Safaeinejad Zahra , Nasr-Esfahani Mohammad Hossein , Marandi Sayed Mohammad
Published: March 2023

Background and Aim:
Type 2 diabetes (T2D) begins with prediabetes (PD), whose primary cause is insulin resistance (IR) in the muscle, liver, and adipose tissues, followed by hyperinsulinemia induced by beta (β)-cells and their destruction. As metabolic balance and homeostasis in the human body heavily depend on skeletal muscles, metabolic syndrome (MetS), hepatic steatosis (HS), and T2D may all occur by skeletal muscle failure. Improving understanding of the molecular mechanisms of muscle energy homeostasis and IR may accordingly help in discovering novel methods for combating metabolic disorders, like T2D. In this way, MondoA, an essential glucose-responsive transcription factor regulated by nutrients, such as glucose 6-phosphate (G6P), can reduce the increased amount of glucose inside the cell and prevent more glucose from entering the cell by amplifying the expression of two insulin pathway suppressors, viz, thioredoxin-interacting protein (TXNIP) and arrestin domain containing protein 4 (ARRDC4), under normal conditions. Against this background, the main objective of the present study was to examine the effects of aerobic exercise (Exe) alone and in combination with green coffee (GC) and chlorogenic acid (CGA) intake on the MondoA activity and the expression of its target genes in the skeletal muscles of a high-fat diet (HFD)-induced PD mouse model.
Materials and Methods
To develop PD, the C57 black 6 (C57BL/6) mice recruited in this study received an HFD for 12 weeks. Upon confirming the PD induction, the animals were given Exe, GC, CGA, or their combination for 10 weeks. Afterward, the metabolic data, i.e., fasting blood sugar (FBS), glucose tolerance test (GTT), the homeostatic model assessment for IR (HOMA-IR) index, plasma insulin levels, together with the cellular localization of MondoA and glucose transporter type 4 (GLUT4), as well as the TXNIP and ARRDC4 expression in the myocytes from various groups were evaluated.
Results
After administering the treatments in this study, the results established a downward trend in the TXNIP and ARRDC4 expression, a drop in the presence of MondoA in the cell nucleus, and a rise in GLUT4 in the muscle cell membrane.
Conclusion
By reducing the MondoA activity in the cell nucleus and expanding the presence of GLUT4 in the cell membrane, Aerobic exercise alone and in combination with green coffee and chlorogenic acid intake may be thus useful in lowering blood sugar and improving PD conditions in mice.
Multi-metal Nanozyme properties for colorimetric peroxidase reaction: Overview of an applicable method validation
Authors: Ravannakhjavani Fatemeh , Dehghan Somayeh Farhang , Panahi Davod , Moradpoor Zahra , Zendehdel Rezvan
Published: March 2023

Displacement of enzyme mimic nanomaterials has been developed due to disadvantages of natural enzymes. Peroxidases reaction could be used for H2O2 colorimetric evaluation in different media. We aim to develop a new method based on the best catalytic activity of metal Nanozyms. A method for H2O2 detection was carried out by TMB peroxidation of metal nanozymes. In this way peroxidase activity of Ag-nano zeolite Y, Cu-nano zeolite Y, Zn-nano zeolite Y and Ag,Cu,Zn -nano zeolite Y was evaluated by Central Composite Design. Total of 28.42 % from three metals was exchanged in multi metal nano zeolite Y (mMy) with higher peroxidase- like activity. Nanozyme Km and Vm were evaluated 0.076 and 8.76×108, respectively which produced fast and sensitive catalytic reaction.H2O2 method detection carried out by LOD level of 0.12 ppm, and recovery parameters of 99%, in the linear range of 0.5-50 ppm.The mMy nanozyme was validated for H2O2 colorimetric detection. In conclusion an applicable way as a fast, sensitive, accurate and reproducible method has been suggested for occupational exposure monitoring. Performance of validated method is higher than international OSHAVI-6 method.
A fuzzy approach to provide different information retrieval results for the same query
Authors: Chkiwa Mounira , Achour Fatma
Published: March 2023

In this paper, we present a feature of our information system which provide different results for users even they submit the same query. This differentiation is due to a main input taken in consideration: the user’s age. Besides of this input, results differentiation is based on the centralized document valorization defined in this paper. A centralized Web document’s content is mainly concise and focusing on the user interests materialized by keywords query. While an information retrieval process, web documents are ranked according to their relevance to a user query. This ranking is changed afterward by the valorization of centralized Web documents. The valorization value is based on the document features and the user age. This value could be positive or negative implying thus the enhancement of the ranking of the concerned document or its rank decrease. Hence, the users of our information retrieval system can get different results according to their ages even submitting the same query.
Graphene nanoplatelets/hydroxyapatite in PMMA composites for enhanced electrical properties
Authors: Abdullah Ahmed Q. , Ali Nadia A. , Hussein Seenaa I.
Published: March 2023

In this article, the casting method was used to prepare PMMA/hydroxyapatite nanocomposite films incorporated with contents graphene nanopalates (Gnp) of nano-size with combined loadings ranging from 0.5 to 1.5 weight %. The nanocomposite was characterized using Fourier transforms infrared (FTIR) spectroscopy, and. Scanning Electron Microscopy (SEM) analysis of the prepared sample, thermal conductivity, and the electrical properties at (1-10MHz) of the samples. The results for FT-IR, and SEM showed that the resulting material had a low agglomerated state, with multiple wrinkles of graphene flakes in the matrix of the PMMA. The thermal conductivity increased and improvement between (0.05–1.82) w/m.k and the electrical properties of nanocomposites revealed a significant improvement with increasing the amount of graphene also that exponent s between (1.25 < s < 1.35). The values of real part ɛ' and imaginary part ɛ’’ were reduced at the lower frequency and became constant at high frequency attributed to the relaxation time. The values of ε″ are high at low frequencies and it is decrease with increase frequencies due to polarization effects or to the dipoles not begins to follow the field variation at higher frequencies. The increase in tan δ with increase in Gnp content due to interfacial polarization mechanism occurred in the films corresponding to frequencies.
Oral health and individuals with a lived experience of an eating disorder: a qualitative study
Authors: Norrie Tiffany Patterson , Ramjan Lucie , S.Sousa Mariana , George Ajesh
Published: March 2023

The authors have requested that this preprint be removed from Research Square.
Effects of Parents' Health on Children's Educational Attainment
Authors: Ahn Joonhong
Published: March 2023

This paper examines the effects of parental health on children's educational attainment. Parental illness changes parenting quality both by affecting family wealth and in other ways that influence children's labor market outcomes by creating an educational environment and extra educational opportunities in childhood. Longitudinal data from the Korean Labor Income Panel Survey, for the period 1998 - 2018, enables me to examine parental illness effects in the early childhood and adolescent periods on children's ultimate educational achievement. Empirical application in this paper considers the effects of both unexpected and chronic health problems on children's human capital. We find that a parent's health problems, especially in the early childhood period, are strongly associated with a child's education.
JEL Codes: J62, I14, I24, I26
Prevalence of intestinal stoma complications and associated factors among children in Uganda, a cross sectional study
Authors: Kimbugwe Godfrey , Kakembo Nasser , Kisa Phyllis , Okeny Paul , Sekabira John
Published: March 2023

Purpose: Intestinal stomas are a common procedure performed in children. They carry a high complication rate which affects the child, family and hospital. This study was aimed at documenting these complications and their associated factors.
Methods: This was a cross-sectional study carried out at the paediatric surgery unit of Mulago Hospital which is the main referral hospital in Uganda over a period of one and a half months. It included 131 children whose caretakers were interviewed and children physically assessed for presence of intestinal stoma complications.
Results: The mean age was 2 years (SD±1) with a male to female ratio of 1.3:1. Anorectal malformation (ARM) (77/131) was the most common indication for stoma formation followed by Hirschsprungs disease (25/131). Sigmoid colon was the most exteriorised part (104/131) followed by ileum (27/131). Children with intestinal stomas who developed complications were 83/131 with peristomal dermatitis being the most common complication (54/131) followed by stoma prolapse (5/131). The factors associated with intestinal stoma complications were stoma placement after the age of 12 months (OR 10.7, CI 1.47-17.62, p-value 0.019) and exteriolization of the ileum (CI 0-0.66, p-value 0.028).
Conclusion: The prevalence of intestinal stoma complications is high in Uganda with stoma placement after the age of one year and having an ileostomy as the associated factors. Sigmoid divided colostomies and prioritization of children with ileostomies for stoma reversal will help to significantly reduce intestinal stoma complications.
Low-temperature Small-angle Electron-electron Scattering Rate in Fermi Metals
Authors: Arulsamy Andrew Das
Published: March 2023

Low-temperature elementary conductivity formula in Fermi metals is reviewed starting from Ohm’s law. This provides the background needed to understand why and how the equations exploited are complicated due to effective mass effect and complex scattering rate even in the presence of small-angle electron-electron scattering at low temperatures. Using the mathematical conditions and physical arguments exploited to derive the Drude conductivity formula, we arrive at our main result—the analytic scattering rate formula at low temperatures that gives rise to the famous T2 dependence without any ad hoc constants. Our derivation formally proves that the formula, 1/τ = (A/ℏ)(kBT)2/EF first guessed by Ashcroft and Mermin to be correct where A = Nimpurity/4π2 and Nimpurity is the number of impurities (or scattering centers) present in a given sample. We also highlight the discovery of a new fundamental physical constant, λArulsamy = [3ℏ2(4πε0)2]/[mele4] that associates quantum mechanical energy with that of thermal energy, and is also related to Rydberg constant.
PACS: 72.10.Bg; 72.10.-d
Distribution and relationship of antibiotics, heavy metals and resistance genes in the Hanjiang Reservoir, Shiyan, China
Authors: Jing LI , Li Lijuan , Li Qin , Fang Wen , Sun Yonghao , Lu Yu , Wang Jing , Zhu Yanrong , Zhang Yao
Published: March 2023

The Hanjiang Reservoir is an important water source for the middle route of China's South-to-North Water Diversion Project. The problems of water and soil quality in the Hanjiang reservoir have enormous biological and environmental impacts, resistant genetic contamination has emerged, but only few studies are concerned the correlation between heavy metals and metal resistance genes (MRGs). In this study, 8 antibiotics and 19 heavy metals were analyzed, the results showed that the highest antibiotic content was tetracycline, with mean concentrations of 43.2 µg/kg and 0.0221 µg/L. Mn was the highest heavy metal in soil with a content of 1,408.28 µg/kg, and in water was Zn with a content of 10.61 µg/L. We found that the most abundant antibiotic resistance genes (ARGs) and MRGs in the study area were bacA and arsT genes, coding for resistance mechanisms to bacitracin and arsenic, respectively. The data showed that heavy metals had a greater impact on antibiotic genes than antibiotics, and antagonism between resistance genes was more significant. This work expands our understanding of the correlations of antibiotics, heavy metals, and resistance genes in the Hanjiang reservoir, indicating that more attention should be paid to the effects of resistance genes and the quality of water.
Human clostridia improve visceral hypersensitivity in stressed mice through upregulation of 5-hydroxytryptamine 4
Authors: Xiao Yaodong , Miao Bei , Li Bowen , Li Li , Fei Sujuan , Zhao Yanchao
Published: March 2023

Background
Clostridium improves intestinal motility by modulating intestinal 5-hydroxytryptamine (5-HT) levels. However, there are few studies on human clostridia.
Aims
To evaluate whether human clostridia improves visceral hypersensitivity through the 5-HT4 pathway.
Methods
An irritable bowel syndrome (IBS) model was established using water avoidance stress (WAS) mice. WAS mice were treated with saline, human clostridial solution (enriched with Clostridium clusters IV ), prucalopride, PCPA, or RS39604 for 1 week, and group differences in body weight, fecal traits, abdominal withdrawal reflex (AWR), and electromyography results were evaluated. Group differences in SLC6A4, TPH1, 5-HT4, PKA, CREB, and pCREB expression in the distal colon and hippocampus and in the number of 5-HT4-expressing intestinal cells were also evaluated. Fecal short-chain fatty acid levels were measured.
Results
WAS mice showed slower body weight gain, lower fecal water content and Bristol score, and higher visceral sensitivity than the normal group. 5-HT4, PKA, CREB, and pCREB levels and the number of 5-HT4-expressing intestinal cells were lower in the distal colon and hippocampus in WAS mice than in normal mice. After 1 week, human clostridia treatment was superior to other treatments, and the levels of 5-HT4 signaling protein in the intestine and hippocampus and 5-HT4-expressing intestinal cells increased. The TPH1 antagonist PCPA or the 5-HT4 receptor antagonist RS39604 could interfere with the therapeutic effect of the bacterial solution, and human clostridia elevated fecal isovaleric acid levels.
Conclusion
Human clostridia improved visceral hypersensitivity by upregulating 5-HT4 signaling protein expression in the distal colon and hippocampus, demonstrating its therapeutic potential.
Experience of Psychosocial Rehabilitation; Perspectives of Depressed Adolescents
Authors: Kodzo Lalit Dzifa , Danso Nana Ama Asi , Budu Jemima Twumwaa , Kafle Baral Akriti , Zhang Ruixing
Published: March 2023

Given the multifaceted character of depression and its related symptoms, an adolescent living with it is at increased risk for a wide range of adverse events. This research aimed to understand and characterize the psychosocial rehabilitation experiences of depressed adolescent participants in the Greater Accra Region of Ghana. A cross-sectional semi-structured interview design influenced by an interpretive phenomenological analysis (IPA) technique was adopted. A nonprobability, purposeful approach to sampling was employed to recruit twenty-one adolescents (6 males, 15 females) from the community diagnosed with depression, discharged from admission for a month, and undergoing psychosocial rehabilitation. Using separate interviews, we gathered data and analyzed using interpretive phenomenological analysis to produce themes and sub-themes. These were presented with the participants' direct quotations. We discovered that the perspectives of adolescents' psychosocial rehabilitation experience include hopelessness and suicide ideation, coping difficulties, undesirable attitudes from support networks, challenges related to school, and isolation. Participants suggested appropriate therapeutic environments, encouraging support systems, and the media's role in preventing and treating depression among young people as rehabilitation approaches that could assist adolescents realize their “hoped-for” selves despite the diagnosis with depression. These results shed light on the tragic realities faced by depressed adolescents, confirming the urgent necessity to focus on their plights to aid in their rehabilitation and develop their coping strategies for a better life.
Discovery, mechanisms, and engineering of the missing apiosylation step in the biosynthesis of flavonoid apiosides in Leguminosae plants
Authors: Wang Hao-Tian , Wang Zi-Long , Chen Kuan , Yao Ming-Ju , Zhang Meng , Wang Rong-Shen , Zhang Jia-He , Ågren Hans , Li Fu-Dong , Li Jun-Hao , Qiao Xue , Ye Min
Published: March 2023

Apiose is a natural pentose containing an unusual branched-chair structure. Apiosides are bioactive natural products widely present in the plant kingdom. However, the essential apiosylation reaction in the biosynthetic pathways of apiosides has been missing. In this work, we report the first apiosyltransferase GuApiGT, which from medicinal plant Glycyrrhiza uralensis. GuApiGT could efficiently catalyze 2″-O-apiosylation of flavonoid glycosides, and exhibits strict sugar donor selectivity towards UDP-apiose. We solved the crystal structure of GuApiGT, determined a key sugar-binding motif (RLGSDH) through structural analysis and theoretical calculations, and obtained mutants with altered sugar selectivity through protein engineering. Based on the motif, we discovered 121 candidate apiosyltransferase genes from Leguminosae plants, and identified the functions of 4 enzymes. Moreover, we introduced GuApiGT and its upstream genes into Nicotiana benthamiana, and completed de novo biosynthesis of a series of flavonoid apiosides, including the anti-tussive compound liquiritin apioside at a yield of 5.46 mg/g (DW).
Microwave electrometry with bichromatic electromagnetically induced transparency in Rydberg atoms
Authors: Han Mingzhi , Hao He , Song Xiaoyun , Yin Zheng , Parniak Michal , Zeng Qingtian , Peng Yandong
Published: March 2023

A scheme for measuring microwave (MW) electric (E) fields is proposed based on bichromatic electromagnetically induced transparency (EIT) in Rydberg atoms. A bichromatic control field drives the excited state transition, whose absorption shows three EIT windows. When a MW field drives the Rydberg transition, the EIT windows split and six transmission peaks appear. It is interesting to find that the peak-to-peak distance of transmission spectrum is sensitive to the MW field strength, which can be used to measure MW E-field. Simulation results show that the measurement accuracy could be increased by about 4 times, and the minimum detectable strength of the MW E-field may be improved by about 3 times compared with the common EIT scheme. After the Doppler averaging, the minimum detectable MW E-field strength is about 5 times larger than that without Doppler effect. Also, we investigate other effects on the sensitivity of the system.
Low expression of NR1D1 and NR2E3 is associated with advanced features of retinoblastoma
Authors: Ding Jie , Sun Jie , Ma Rui-Qi , Zheng Ke , Han Yi-Nan
Published: March 2023

Purpose
To investigate the expression of nuclear receptor subfamily 1 group D member 1 (NR1D1) and nuclear receptor subfamily 2 group E Member 3 (NR2E3) in retinoblastoma (RB) and their correlation with the clinical and pathological features of RB.
Methods
Immunohistochemical (IHC) assays were performed to detect and evaluate the expression levels of NR1D1 and NR2E3 in paraffin-embedded tissue samples. The relationship between the expression levels and clinicopathological characteristics of RB patients was analyzed using the χ2 test or Fisher exact test.
Results
A total of 51 RB patients were involved in this research. The expression levels of NR1D1 (P=0.010) and NR2E3 (P=0.007) were significantly lower in RB tumor tissues than in normal retina. The expression levels of NR1D1 and NR2E3 were less positive in RB patients with advanced stages (P=0.007, P=0.015), choroidal infiltration (P=0.003, P=0.029), and optic nerve infiltration (P=0.036, P=0.003). In addition, a low expression level of NR2E3 was associated with high-risk pathology (P=0.025) and necrosis (P=0.035) of RB tissues.
Conclusion
The expression levels of NR1D1 and NR2E3 were decreased in RB and closely associated with the clinical stage and high invasion of the disease.These findings provide new insights into the mechanism of RB progression and suggest that NR1D1 and NR2E3 could be potential targets for treatment strategies.
A Week in the Life of the Human Brain: Stable States Punctuated by Chaotic-Like Transitions
Authors: Wang Maxwell , G'Sell Max , Richardson R. Mark , Ghuman Avniel
Published: March 2023

Critical neurocognitive processes, such as performing natural activities and fluctuations of arousal, take place over minutes-to-days in real-world environments. Here we harness the opportunity to study brain dynamics during real-world behavior continuously for 3-12 days using multi-electrode intracranial recordings in twenty humans. During this time, participants engaged in natural activities, including interacting with friends, family, and staff, watching TV, sleeping, etc., with simultaneous neural and video recordings. We found that brain network dynamics predicted neurocognitive phenomena such as circadian rhythm, arousal, and multiple aspects of behavior (socializing, watching a screen, etc.). The individual functional networks, as well as their pairwise interactions, possessed simple and stable dynamic properties that were conserved over days. In contrast to single or paired network behavior, the mixture of all functional networks showed patterns of “punctuated equilibrium”: periods where networks would remain in stable states that corresponded to behavior and were interrupted by transitory bursts that were difficult to predict, displayed chaotic characteristics, and coincided with behavioral transitions. Brain state statistics displayed power laws characteristic of critical dynamics that are a trait of systems where complexity emerges from simple and stable building blocks. These results indicate that the complex and flexible brain dynamics that underpin real-world behavior are an emergent property of mixtures of individual, stable networks with simple dynamics.
Impact of mining enterprises on tax revenues of the budget of the Republic of Komi
Authors:   Institute of Social, Economic and Energy Problems of the North, Komi Scientific Center of the Ural Branch of RAS, BURTSEVA Irina Grigor’evna , TIMUSHEV Evgeniy Nikolaevich ,   Institute of Social, Economic and Energy Problems of the North, Komi Scientific Center of the Ural Branch of RAS
Published: March 2023

Relevance. The problems of the withdrawal of natural resource rent in the development of mineral deposits have been relevant throughout the history of the development of natural resources, and they are of particular importance at the present stage, when the demand for a fair distribution of income comes to the fore in the economic and political development of society. The task of determining a reasonable economic assessment of mineral raw materials is one of the most difficult to solve in the field of environmental economics due to the huge variety of mineral deposits that are difficult to unify, price volatility, differentiated economic conditions for development, etc. The purpose of the research – determination of the degree of withdrawal of the potential value of mineral raw materials in the bowels through tax revenues generated by the mining enterprises of the republic. Research methodology. During the research, methods of economic and statistical analysis, economic and geographical analysis were used, monographic, abstract-logical, analytical, systematic approaches were used. Results. In the course of the study, a cost estimate was made of the mineral resource potential of the Komi Republic, which was based on the methodological recommendations of the Russian Geological Research Institute named after A. P. Karpinsky (VSEGEI), experts in the field of mineral raw material evaluation and the author’s methodology. The analysis of the main approaches of tax policy in the world practice was carried out, which, with all the existing differences between countries, testifies to the main goal of the fiscal policy of taxation of the mining industries – the maximum withdrawal of profits while maintaining the interest of entrepreneurs in continuing the high-risk mining business. The paper considered tax revenues generated in the extractive sector of the region’s economy, which were compared with the main macroeconomic indicators of the Komi Republic and the Russian Federation, as well as the results of the valuation of the mineral resource potential. Conclusion. As a result of the study, the dual role of taxation of the mining industry is shown – the vast majority of tax revenues are generated in the mineral resource sector, but the existing budget rules lead to the fact that at the regional level their role is significantly reduced. This should serve as an incentive to expand the opportunities for the development of deposits of local raw materials, the income from the development of which serves as a source of replenishment of the regional budget.
The use of fine fractions of waste from stone quarries in Azerbaijan as sand in the preparation of concrete
Authors:   Ural State Mining University, VALIEV Niyaz Gadym ogly , AFANDIYEVA Zarifa Jahangir kyzy ,   Azerbaijan State Oil and Industry University, OSMANLY Takhim Rustam ogly ,   Azerbaijan State Oil and Industry University
Published: March 2023

Relevance. In recent years, the enterprises of the construction industry of the republic are experiencing an acute need for inert materials, especially for fine aggregates. The sand deposits available in Absheron are very insignificant and, moreover, in some cases do not meet the requirements of regulatory documents. As a result, it is necessary to use imported sands, which are also not always of satisfactory quality due to their significant fine grain and high content of clay and silt particles. In addition, the use of imported sands significantly affects the cost of finished products. Therefore, the study of the possibility of using fine fractions of stone quarry waste instead of sand in the preparation of heavy concrete is very timely and of undoubted interest. In the article, the characteristics of the materials used for the preparation of concrete are considered in sufficient detail, the main properties of limestone sand with different content of dust particles are investigated, the influence of the properties of limestone sand on the strength characteristics of concrete and their resistance to various temperature and humidity influences is studied. For the purpose of comparison, samples were simultaneously made using river sand from the Mingechevir deposit. The obtained results show that in concrete on gravel and crushed stone when using limestone sand, in comparison with concrete on natural sand, the consumption of cement per 1m3 of concrete slightly increases. The purpose of the research. The article deals with the problem of using fine fractions of stone quarry waste as sand in the preparation of concrete. Research methodology. A simple technique was used to determine the volume increment upon swelling. The physical and mechanical tests of sand have been conducted, the study of the particle size modulus when mixed with gravel and crushed stone and the ability to increase volume during swelling are shown. Results. The use of cheap local wastes of shell limestones as small and large aggregates of concrete will make it possible to somewhat cover the need of the construction industry of the republic for aggregates, especially for fine aggregates. Conclusions. Limestone sands obtained by sawing the shell limestones of the Apsheron Peninsula are a suitable fine aggregate for the preparation of concrete.
Climate change and scarcity of water resources in Algeria
Authors:   Peoples’ Friendship University of Russia (RUDN University), ZERDOUMI Imed Eddine , ABRAMOV Vladimir Yur’evich ,   Peoples’ Friendship University of Russia (RUDN University)
Published: March 2023

The importance of work is due to the importance of water in the continuation of human life and its great role in practicing its various activities, which concern industry, agriculture and various fields. The research methods included the increasing scarcity of water resources resulting from the decrease in the quantities available to the individual, the deterioration of the quantity and the objectives of economic and social development, thus imposing the development and definition of a water management strategy in the medium and long term. In recent years, the water scarcity crisis has increased and exacerbated due to the drought wave that the region suffers from, and it has greatly affected the region. As a result of the research, by the year 2025, a deficit of one billion cubic meters of water will be recorded. It is also possible to avoid this deficit in the hydrographic region of Constantine – Seybousse – and this is due to the dams that are in the process of being completed. In order to eliminate the shortage of water in the region, the amount of storage in dams must be increased and water desalination plants should be established in several areas in order to re-use wastewater. We can also avoid the shortage in the amount of water by building small dams and hill reservoirs, and this is to avoid siltation in large dams. Among the solutions are also increasing surface and groundwater resources, searching for new resources, dealing with losses, and improving the quality of available water.
Vortex states in a PbTiO$_3$ ferroelectric cylinder
Authors: Kondovych Svitlana , Pavlenko Maksim , Tikhonov Yurii , Razumnaya Anna , Lukyanchuk Igor
Published: March 2023

The past decade’s discovery of topological excitations in nanoscale
ferroelectrics has turned the prevailing view that the polar ground
state in these materials is uniform. However, the systematic
understanding of the topological polar structures in ferroelectrics is
still on track. Here we study stable vortex-like textures of
polarization in the nanocylinders of ferroelectric
PbTiO_33,
arising due to the competition of the elastic and electrostatic
interactions. Using the phase-field numerical modeling and analytical
calculations, we show that the orientation of the vortex core with
respect to the cylinder axis is tuned by the geometrical parameters and
temperature of the system.
Transformation of accounting systems in different countries under the influence of convergent processes
Authors: Zhuravka Fedir
Published: March 2023

The harmonization process of accounting and reporting systems with the international standards is associated with a number of problems, which arise at different stages of implementation, not allowing to realize properly innovative development of the national economies and international investment projects. The monograph highlights the issues and perspectives of accounting and reporting systems transformation in different countries under the influence of IAS and IFRS.
Harnessing the Therapeutic Potential of Antimicrobial Peptides for
Cancers: State of the Art
Authors: Mahjoubin-Tehran Maryam , Rezaei Samaneh , Aghaee-Bakhtiari Seyed Hamid , Sahebkar Amirhossein , Oskuee Reza Kazemi , Mahmoudi Ali , Jalili Amin
Published: March 2023

Despite significant breakthroughs in cancer treatment, cancer remains a serious global health concern that takes thousands of lives each year. Still, drug resistance and adverse effects are the main problems in conventional cancer therapeutic approaches. Thus, the discovery of new anti-cancer agents with distinct mechanisms of action is a critical requirement that offers significant ob-stacles. Antimicrobial peptides (AMPs), which can be found in various forms of life, are recognized as defensive weapons against infections of microbial pathogens. Surprisingly, they are also capable of killing a variety of cancer cells. These powerful peptides can cause cell death in the gastrointesti-nal, urinary tract, and reproductive cancer cell lines. To emphasize the anti-cancer properties of AMPs, we summarize the research that examined their impact on cancer cell lines in this review.
An Update on Eating Disorders
Authors: Hussain Md. Sadique , Sharma Neha , Khurana Navneet
Published: March 2023

It is no surprise that eating disorders (EDs) are increasing all over the planet. With the
emergence of global westernization, development in technology, and societal changes, nearly all
regions of the globe have been influenced by the concept of a perfect body image and height.
EDs are a considerable public concern, a bewilderment for psychologists and a challenge for
physicians. The primary EDs include anorexia nervosa (AN), bulimia nervosa (BN), and binge
eating disorder (BED). AN is an ED that is psychological and possibly life-threatening. Usually,
people with AN experience an exceedingly low body weight due to their height and body shape.
The highest rate of occurrence is between 14 and 17 years of age. BN is an extreme, lifethreatening,
neurological ED in which you have binge eating cycles. You may not have any
sense of balance in your diet throughout these binges. The weight-control engagement of patients
with AN and BN results in various physiological shifts. EDs can control your lives and can be
quite hard to cope with. Yet you will develop a better understanding of who you are by therapy,
return to healthy eating and exercise, and undo any of the severe complications of AN. Investigation
into EDs has yielded valuable new information over the past few decades, notably involving
the psychological features and care of patients. The purpose of this study/review is to expand the
knowledge of the people about these EDs, their global burden, diagnostic criteria, risk factors,
medical complications, management, and the newly added avoidant/restrictive food intake disorder.
Synthesis and Electrochemical Applications of Carbon Nano-onions
Authors: Castaño Jorge A. , Betancourth Jolaine G. , Caicedo Dahiana L. , Visbal Renso , Chaur Manuel N.
Published: March 2023

Carbon nano-onions, a family of carbon nanomaterials, consist of multiple concentric fullerene-
like carbon shells which are highly defective and disordered. Due to their unique physicochemical
properties, such as high conductivity, high surface area, biocompatibility, thermal stability, and
others, they are promising nanomaterials for different electrochemical applications. In this sense, this
review outlines the synthetic methods available to afford carbon nano-onions in their pristine, functionalized
(covalent and non covalent) and doped forms and their use in energy storage, electrocatalysis
and sensing. Particularly, we review the performance and properties of carbon nano-onions as electrode
materials for supercapacitors, electrocatalysts in different reactions for fuel cells, and electrode
materials for sensors. In the last decade, as we will discuss, scientists have found that functionalized
and doped carbon nano-onions have better electrochemical properties than pristine carbon nanoonions,
such as specific capacitance, surface wettability, energy power, adsorption on an electrode
surface, and charge delocalization, among others.
Myocarditis and Pericarditis Related to mRNA COVID-19 Vaccination: A
Case Report
Authors: María Pérez López Elena , Diego Rangel Sousa , Jorge Navarro Roldán
Published: March 2023

Introduction:

Reported cases after the post-commercialization phase of mRNA vaccines
against COVID-19 have revealed that myocarditis and pericarditis may occur predominantly in
male adolescents after the second dose of the vaccine.

Case Presentation:

We report two cases of cardiac disorders associated with mRNA COVID-19
vaccination, both of them in 15 year-old males. One of the patients presented acute pericarditis and
the second one presented acute myocarditis with left ventricular dysfunction at hospital discharge.

Discussion and Conclusion:

Physicians should be aware with the typical manifestations of these
cardiovascular events after the vaccination and report suspicious cases to pharmacovigilance agencies
as soon as possible. The population should rely on the pharmacovigilance system that continues
to recommend vaccination as the most effective strategy to reduce the negative consequences
of the pandemic.
The Cell Death and Signal Transduction Mechanisms in Colorectal Carcinogenesis:
Recent Advances
Authors: Kashyap Monu Kumar , Ved Akash , Yadav Rajiv Ratan Singh , Singh Akhand Pratap , Kushwaha Mahima , Shukla Karuna S.
Published: March 2023

In underdeveloped nations, colorectal carcinogenesis (CRC) is a significant health issue. It is the third most
common outcome of cancer death. Despite a variety of therapy options, new medications are needed to lessen the severity
of this condition. In the colon, adenomatous polyps are the most common cause of CRC, occurring in 45 percent
of cases, particularly in patients over 60 years old. Inflammatory polyps are acquiring popularity in CRC, as well as
inflammation appears to exert a function in the disease, according to mounting research. The azoxymethane, dimethyl
hydrazine, APCmin/+ mouse model, and a combination of sulfated polysaccharides composed of dextran and sulfated
and dimethylhydrazine are among the experimental models used to study CRC in animals. Numerous signal transduction
pathways are engaged as CRC progresses. The p53, TGF-β, Delta-Notch, Salvador-Warts-Hippo (SWH), and
Kelch-like ECH associated protein 1 pathways are among the key signal transduction pathways. To decide cell destiny,
several signalling pathways work in tandem with the death of cell modalities, such as autophagy, necroptosis,
and apoptosis. In our lab, we have spent a lot of time looking into the cell signalling and mechanisms of cell death in
CRC. The pathogenesis of CRC, as well as the associated cell death and cell signalling pathways, are summarised in
this study.
Parametric Study on the Influence of Pedestrians' Road Crossing Pattern on Safety
Authors: Prakash Sathya , Karuppanagounder Krishnamurthy
Published: March 2023

Objective:

The present research concentrates on studying the road crossing time of pedestrians based on their pattern of the road crossing. The factors that influence the road occupancy time due to the irregular road crossing patterns of pedestrians have been studied.

Methods:

The research used a videographic survey of three midblock locations with different land-use types. The pedestrian variables from the video data are extracted to excel using a custom-made video player. The data set consists of 8718 pedestrian data, including all three sites, and the data is analysed using statistical methods. A binary logit analysis is performed to predict the variable influencing the crossing time High/Low.

Results:

According to the analysis, females making path changes and an increase in stage number show a higher road crossing time for pedestrians. Also, the absence of motor vehicles results in a higher road crossing time for pedestrians. The prediction accuracy of the model is 58.2%, and a variance of 6% shows a lesser degree of spread in the dataset.

Conclusion:

The inference from the study is that the crossing time of path-changing pedestrians is more than straight-moving pedestrians. Thus, an increase in road crossing time decreases the safety of pedestrians by increasing the exposure rate while crossing the road. So, the probability of safety risk is high when they practice irregular road crossing patterns.
The Effects of Different Temperaments on Vascular Parameters: A Pilot
Crossover Randomized Controlled Trial
Authors: Zakerian Mohsen , Roudi Fatemeh , Rezvani Reza , Jarahi Lida , Yousefi Mahdi , Anoushirvani Majid , Sahebkar Amirhossein , Motavasselian Malihe
Published: March 2023

Background:

According to the Persian Medicine (PM) point of view, the function of
the cardiovascular system and the risk of cardiovascular events would be different between subjects
having warm and cold temperaments. Moreover, different foods in terms of temperament
may lead to different acute and chronic effects on the body.

Objectives:

We investigated the postprandial effects of PM-based warm and cold test meals on arterial
stiffness indices in healthy men with warm and cold temperaments.

Methods:

Twenty-one eligible warm or cold temperament subjects with a similar range of age,
weight, and heights were enrolled in this pilot cross-over randomized controlled trial study during
February- October 2020. Two test meals (cold and warm PM-based temperament foods)
were designed as different interventions. Pulse wave velocity (PWV) and pulse wave analysis
(PWA) was obtained at the baseline state (following 12 hours fasting), 0.5, 2, and 4 hours after
the test meal consumption during each test day.

Results:

Warm temperament participants had higher values of lean body mass, total body water,
and protein content (P = 0.03, 0.02, and 0.02, respectively). Cold temperament individuals had
higher aortic heart rate (HR) following 12 hours of fasting (P <0.001). On the other hand, the
augmentation pressure (AP) of warm temperament individuals was higher than the colds (
P = < 0.001).

Conclusion:

According to the results of the present study, although warm temperament individuals
could have higher arterial stiffness at the fasting state, arterial stiffness indices had a greater
reduction following warm-temperament meal intake compared to cold-temperament meal.

Trial Registration number::

International Clinical Trials Registry Platform IRCT20200417
047105N1 (Where the full trial protocol can be accessed).
Üniversite Öğrencilerinin Aile Planlaması ve Cinsel Temasla Bulaşan Hastalıklara İlişkin Bilgi Düzeyi
Authors: SARI Canan , ADIGÜZEL Leyla , DEMİRBAĞ Birsel Canan
Published: March 2023

Amaç: Bu çalışma, sağlık alanında eğitim gören üniversite öğrencilerinin Aile Planlaması (AP) ve Cinsel Temasla Bulaşan Hastalıklar (CTBH) ile ilgili bilgi düzeyinin belirlenmesi amacıyla planlanmıştır. Yöntem: Çalışmanın örneklemini Türkiye’nin doğusunda bir şehirde sağlık alanında ön lisans eğitimi gören 304 öğrenci oluşturmuştur. Çalışmanın verileri “Kişisel Bilgi Formu” ve “Cinsel Temasla Bulaşan Hastalıklar (CTBH) ile ilgili bilgi testi” kullanılarak toplanmıştır. Bulgular: Öğrencilerin %58,8’inin lise eğitimini sağlık alanında bir meslek lisesinde tamamladığı, %75,6’sının AP bilgi düzeyini eksik bulduğu, % 68,7’sinin cinsellikle ilgili konuları ebeveynleri ile paylaşmadığı, en sık bilinen AP yönteminin prezervatif olduğu, %65,1’inin CTBH ile eğitim almak istedikleri belirlenmiştir. Öğrencilerin CTBH ile ilgili bilgi testi toplam puan ortalaması X+SS:13,24+3,08 (min:7 / maks: 22) olarak belirlenmiştir. Cinsiyet daha önce eğitim görülen lise, yaşanılan yer ve CTBH ile ilgili bilgi alma durumu ile CTBH ile ilgili bilgi testi toplam puan ortalaması arasında istatistiksel olarak anlamlı farklılık belirlenmemiş (p>0,05); ikinci sınıfta eğitim gören öğrencilerin CTBH ile ilgili bilgi testi toplam puan ortalaması istatistiksel olarak yüksek olduğu belirlendi (p<0,05). Sonuç: Öğrencilerin AP ve CTBH ile ilgili bilgi düzeylerinin yetersiz olduğu, CTBH ile ilgili bilgi testi toplam puan ortalamalarının düşük olduğu ve bu konuda eğitim almak istedikleri saptandı.
THE SIDE-EFFECTS OF COVID-19 VACCINE (CORONAVAC) :A STUDY IN A PROVINCE OF TURKEY
Authors: GÜVEN Oya , KAŞIKEMAN Okay , SELÇUK Hakan , DEMİRELLER Merve , KURT Bedriye Feyza
Published: March 2023

Objective: The discovery of vaccines during the COVID-19 pandemic was encouraged to establish immunity and decrease the effects of the virus. Vaccines, like any other medicine, include the possibility of side effects. This study was carried out to categorize the side effects and to show that no severe side effects developed. In this study, we aimed to examine the patients who came to the emergency department with side effects after administering the inactivated vaccine. Material Methods: In this study, between January and March 2021, healthcare workers and people over 80 who applied to the emergency department after developing a side effect after administering the Coronavirus disease-2019 (COVID-19) vaccine were included. Results: In the study, 82 (82.8%) were healthcare professionals, and 17 (17.2%) were in the over-80 age group. The most common side effect was COVID-like findings (47.5%). While the rate of applications to the emergency department after the first dose of vaccination was69.7% (n=69), it was observed that it decreased to 30.3% (n=30) after the second dose of the vaccine. Conclusion: In general, post-vaccination side effects are tolerable and not life-threatening. Furthermore, the risk of becoming infected with the virus post-vaccination is lower. Therefore, hesitation to vaccinate may cause more risk.