bluuebunny/crossref_metadata_2025 huggingface dataset:
Protection of Patent Right in India
Authors: Kanimozhi G.
Published: April 2023

Abstract: Intellect is the name for brain – created things. These inventions are referred to as property since they have a high commercial value. Patent can be used to protect inventions as intellectual property if they are new, non-obvious, practical, and enable. In general, the patent holder has thesole authority to forbid or stop others from making use of the protected innovation for commercial purposes. In other words, patent protection prevents anyone from using, distributionimporting, or selling the innovation for profit without the patent owner’s permission. Use Indian’s intellectual property protection rules if you generate any type of intellectual property. This is to prevent theft or unauthorized usage of your property. Is your intellectual property product of an invention or innovation? It’s important to comprehend all of India’s patent protection regulations. An agreement between the inventor and the government is what is referred to as a patent. Excluding others from producing, selling, offering to sell, licensing, and improperly exploiting any of the rights granted to the patent owner is a monopoly privilege. A products or a procedureis given patent protection. Patent are territorial in nature since they are protected by a national government. Only in the nation in which the patent is protected are patent rights enforceable. There is no such things as a “global patent” that is valid everywhere. The length of a patent’s protection varies depending on the nation, although it typically lasts 20 years from the date of filing. Patents are not awarded so that an inventor or applicant can gain from monopoly rights, but rather so that the innovation can benefit the public and advance the field of research and development
Design of Multilevel Inverter based Active Filter for Harmonic Elimination & Frequency Regulation
Authors: Bandyopadhyay Shubhang , Rout Tathagata
Published: April 2023

Abstract: For harmonic and reactive power adjustment in two-wire (single phase), three-wire (three phase without neutral), and four-wire (three phase with neutral) ac power networks with nonlinear loads, active filtering of electric power has already reached maturity. This article provides a thorough analysis of active filter (AF) designs, control methods, component choices, additional relevant technical and economic factors, and their selection for certain applications. It aims to give researchers and application developers working with AF technology a comprehensive perspective on the state of the technology
REANALYSIS SYSTEM - An Exam’s Result Analysis System
Authors: Samak Vikram Rajendra , Borate Rushikesh Ashok , Atar Prof. Roshani Usman
Published: April 2023

Abstract: The REANALYSIS SYSTEM is an innovative tool that addresses the challenges associated with manual analysis of exam results. This desktop-based application is designed to automate the analysis process, making it more efficient and less prone to errors. With a modern user interface and Telegram bot integration, the REANALYSIS SYSTEM is user-friendly and easy to use. One of the key advantages of the REANALYSIS SYSTEM is that it can complete the analysis process in just 20-30 seconds for a class of 100 students. This is a significant improvement over the 2-3 hours it would take to do the same task manually. This feature makes it a time-saving tool that allows teachers to focus on other important tasks. The REANALYSIS SYSTEM is also designed to reduce the occurrence of errors that commonly arise when performing mathematical calculations and statistical analysis manually. This is especially important in large classes, where the number of calculations involved can be overwhelming. The automation process of the system ensures that every calculation is accurate and error-free. Another notable feature of the REANALYSIS SYSTEM is its ability to generate password-protected reports. This is particularly useful when it comes to maintaining the confidentiality of exam result’s report. Teachers can rest assured that only authorized individuals will have access to the reports. The REANALYSIS SYSTEM is an efficient and reliable tool that simplifies the analysis process of exam results. Its modern user interface, Telegram bot integration, and password-protected reports make it a user-friendly and secure tool. It saves time, reduces errors, and ensures accuracy, making it an essential tool for teachers and educators.
Paradigm Shift of Digital Education Systems in Indian Education Industry
Authors: Gupta Mr. Vivek , Tiwari Dr. Richa , Ojha Devansh , Varun S. , R Dharun Sankar , TS Nithish Kumar , Bahadursha Sanjeev
Published: April 2023

Abstract: The fast adoption of digital technology in the Indian educational system has resulted in a paradigm change in recent years. This research paper aims to study the changing landscape of digital education systems in India and its impact on the education industry. The paper draws on an extensive literature review and associated data analysis to provide insight into the key drivers and challenges of this paradigm shift. The paper also delves into the challenges and limitations of the digital education system in India, including issues related to accessibility, affordability, quality, and equity. It addresses the digital divide, socioeconomic disparities, and unequal distribution of digital infrastructure that hinder the widespread deployment of digital education systems in the country. Furthermore, the research paper explores the potential benefits of digital education systems in India, such as increased access to quality education, personalized learning experiences, and improved outcomes. better learning outcomes. It also discusses emerging trends in digital education, including the use of artificial intelligence, virtual reality, and gamification, which are changing the way education is delivered and consumed in India. In summary, this research paper presents a comprehensive overview of the paradigm shift of digital education systems in the Indian education sector. It highlights the dynamics, challenges, benefits, and trends associated with the adoption of digital technologies in education. The findings of this study contribute to the existing database on digital education and provide valuable insights for policymakers, educators, and stakeholders to shape the future of education in India.
Multi-Parameter Health Monitoring System
Authors: Narayana Mr. K. Lakshmi
Published: April 2023

Abstract: "Multi-Parameter Health Monitoring System" (MPHMS) is an IOT term that describes the collecting and collaboration of patient data from sensors. Sensors, a Raspberry Pi 3 Model B, a GSM Module, and sensors make up the project's hardware platform. The sensors used in this suggested proposal collect the patient's heartbeat, temperature, and electrocardiogram (ECG). This system also monitors the extra Saline level and Falldetection. The sensor data will be stored to be used for patient health analysis in the Thing Speak cloud. These metrics' threshold levels are established in accordance with the general state of health.
An Overview on Detection of Temporary Fault and Permanent Fault for 3 Phase Load
Authors: Lodhe Abhay , Tandekar Ashish , Rokade Mayur , Dhuve Vaibhav , Sakhare Pratiksha , Wagdhare Ajay , Bhopche Harshal , Hiwarkar Dr. Chandrashekhar
Published: April 2023

Abstract: To Maintain reliability in Power System it is important to protect the 3 phase devices like inductive, resistive, etc against various faults occurring in it. This fault should be identified and analysed quickly for their remedies. The Project Aim is to develops an Automatic Tripping mechanism for the three-phase system. In the case of a temporary fault, the output of the project resets automatically within second. While in event of Permanent fault condition the permanent Trip. Due to these faults, the power system may suffer from considerable damage. This can lead to disturbance in power supply and may cause a standstill to various industries linked to the system. In a three phase power system, these faults are classified as LG (Line to Ground), LL (Line to Line), 3L (Three lines). This system can overcome such problem which by sensing the fault automatically and disconnects the system from the supply so that large scale damage to the system equipment can be avoided. The system automatically differentiates between a temporary disturbance and a permanent fault and appropriately cuts the supply for a short duration or long respectively. The purpose of this project is also to send the information to the mobile by using Global system for Mobile Communication (GSM) technology.
Sentiment Analysis for E-Commerce
Authors: Mehta Niyati , Mane Minakshi , Satpute Prathamesh , Mahale Aishwarya , Bhutekar Shivshankar
Published: April 2023

Abstract: The rise of e-commerce has brought about new challenges in understanding customers; needs and preferences. One of the ways to better understand customers is to analyse their feedback on products and services. Sentiment analysis is a powerful tool that can be used to gain insights into customers&; opinions and emotions towards products and services. The proposed project, "Happy Shopping" is an application that uses sentiment analysis to analyse customer feedback on products and services. The interface will display a summary of the most common sentiments expressed by customers for each product or service. This will enable customers to make more informed buying decisions based on the sentiments expressed by other customers. In conclusion, the "Happy Shopping" project aims to leverage sentiment analysis to enhance the customer experience in an e-commerce platform. The project will provide customers with valuable insights into other customers; sentiments towards products and services, as well as improve customer support services.
Entre filosofias e filosofias: o discurso que se faz no mundo
Authors: de Lima Pacheco Marcio , de Assis Costa da Silva Francisco
Published: April 2023

Este livro é fruto de várias pesquisas realizadas ao longo dos anos pelos seus autores. Esses expressam suas formas de pensar para que sejam criticados pelo leitor pois, a pesquisa que não se apresenta para ser apreciada, não tem comprometimento com a verdade. O título revela que a filosofia quer conversar com as mais diversas teorias, que, por várias vezes, são conflitantes entre si. São discursos que se apresentam ao mundo. Isso que se apresenta é a realidade, como diria Ayan Rand, independente da mente do observador em uma visada ética em que se busca a felicidade ou melhor e egoísmo racional, ou seja, a necessidade essencial da presença da razão como orientação moral para o indivíduo. É necessário um objetivismo em tudo no qual os fatos não possam ter qualquer interferência de emoções ou desejos dos homens. Para ser possível a apreensão objetiva da realidade, é necessário que os homens utilizem da razão a fim de melhor notarem a realidade. Portanto, cada leitor tem o comprometimento de fazer suas reflexões e críticas sobre os temas aqui versados.
Influencia de los tipos de agrupamiento en la competencia social de futuros docentes de Educación Física al implementar el aprendizaje cooperativo
Authors: Ortuondo Bárcena Jon , Hortigüela Alcalá David , Meroño García Lourdes , Zulaika Isasti Luis Mari
Published: April 2023

El objetivo de esta investigación fue comprobar la incidencia del aprendizaje cooperativo (AC) en la competencia social en función de los tipos de agrupamiento del alumnado. Participaron 53 estudiantes de tercer curso del Grado de Magisterio Educación Primaria de la mención de Educación Física (EF). Se utilizó un diseño cuasi-experimental donde se implementó una intervención durante cuatro meses con medidas pre-test y post-test a través de un cuestionario sociométrico. El tratamiento de datos se realizó mediante el software Sociomet. Los resultados obtenidos indican que los seminarios que han utilizado agrupamientos libres y heterogéneos han obtenidos mejores puntuaciones de percepción de competencia social que el seminario organizado en subgrupos homogéneos. Así pues, se considera que el criterio de homogeneidad debe ser descartado a la hora de implementar el AC en EF.
Proyectos co-tutorados de Educación Física entre universidad y escuela como contextos de aprendizaje colaborativos
Authors: Nieva Carolina , Martínez-Mínguez Lurdes , Moya Prados Laura
Published: April 2023

La educación superior actual necesita crear más experiencias de aprendizaje que relacionen la teoría con la práctica. El objetivo del estudio es analizar la percepción de docentes sobre el impacto de proyectos cotutorados en entornos de aprendizaje universitario de Educación Física en Infantil en el contexto español. La muestra está formada por 11 maestros y tres profesores. Se ha realizado un estudio de caso intrínseco dentro del paradigma interpretativo, a través de un informe reflexivo, analizando ocho preguntas cualitativas. Los resultados muestran influencias en: alumnado y niños, docentes, colaboración escuela-universidad, familias y asignatura universitaria. Como conclusiones, se detecta un impacto en la mejora de las competencias profesionales de EF del estudiantado y la creación de aprendizajes significativos en el contexto universitario. En las escuelas se ha referido al aumento de reconocimiento de la EF en Infantil por parte de la comunidad educativa y el aumento de formación permanente en el claustro.
Corpo e processos formativos em tempos de pandemia
Authors: Marchezi Tavares Gilead , Duda Sampaio Alice , Manucia Miranda Alves Aressa
Published: April 2023

Este artigo discute processos formativos partindo da análise do corpo e do movimento nas artes performativas para pensar um ethos de aprendizagem inventiva. As limitações impostas pela pandemia da COVID-19 compuseram o debate, tornando a investigação uma análise de experiência, na medida em que as pesquisadoras envolveram seu corpo e seu conhecimento, focalizando seu próprio processo formativo em meio ao isolamento social e ao uso das mídias digitais. Utilizou-se a pesquisa-intervenção para acompanhar os processos de transformação aos quais as pesquisadoras estavam sujeitas na medida em que investigavam. Indica-se novos modos de aprender, lançando mão do dispositivo grupal num ethos de aprendizagem inventiva.
Experiências de Pessoas em Situação de Rua com o Uso de Substâncias Psicoativas: Um Estudo no Contexto do Distrito Federal
Authors: Mello Leonardo Cavalcante de Araújo , Vanazzi Brisa Manuela dos Reis , Lazzaretti Mércia Correia
Published: April 2023

Investigou-se vivências de pessoas em situação de rua que usam/usaram substâncias psicoativas, a partir de um programa de reinserção social e geração de renda, no Distrito Federal. Trata-se de estudo realizado com quatro adultos a partir de entrevistas semiestruturadas. As informações foram analisadas pela Análise de Conteúdo, gerando as categorias: caracterização do uso de substâncias psicoativas; experiência com programas para usuários de álcool e outras drogas; história de vida e a situação de rua; projeto social e uso de substâncias psicoativas. Como resultados, evidenciou-se como os participantes se relacionam com substâncias psicoativas, como o projeto social investigado se configura como potencializador para transformação de vidas. Conclui-se que a história de vida dos sujeitos está ligada à situação de rua e uso de substâncias psicoativas, destacando-se o potencial transformador de programas sociais, possibilitadores de desenvolvimento econômico e social, e que modelos baseados em abstinência se mostraram ineficazes como forma de tratamento.
Diseño de un CanSat para medición de variables ambientales
Authors: Buitrago Paola , Camacho Briñez Raúl , Tejada Juan Camilo , Marmolejo Paola , Jaramillo Oscar Alberto
Published: April 2023

En el diseño de la estructura del pico satelital (CanSat: Can-Satellite), que permite simular las características de un satélite real, integrado en el volumen y la forma de una lata de soda, los principales subsistemas encontrados en un satélite fueron tenidos en cuenta, como potencia, sensores y un sistema de comunicación. La implementación se realiza con una NodeMCU V3 que es una placa de hardware abierto basada en ESP8266 (con un microprocesador Tensilica L106 de 32 bits), que nos permite establecer comunicación con los módulos:GPS, transceptor de RF y sensores; este es uno de los componentes actualmente utilizados para la implementación de sistemas basados en Internet de las cosas (IoT); Esto permite una alta disponibilidad de los componentes, incluidos los sensores, así como un bajo costo para la implementación y fabricación del pico-satélite.
Short-term determinants of banking profitability and financial sustainability of banks in Bangladesh: An empirical study of COVID-19 effects
Authors: Begum Farhana , Islam Kazi Saidul , Saroni Sangida Akter , Rahman Muhammad Khalilur , Sarker Bibhuti Bhusan , Omar Normah
Published: April 2023

The purpose of this study is to examine the profitability and financial sustainability of banks in Bangladesh before and during COVID-19. The study compares the profitability and financial sustainability of 23 listed private commercial banks. The data for short-term periods before the COVID-19 and during the COVID-19 crisis we used. Financial ratios, descriptive statistics, correlation matrix and linear regression model estimations are used for the analysis of data. The mean values of ROA, ROE and NIM are found before the COVID-19 crisis as 0.0019, 0.0270 and 0.0054, and during the COVID-19 as 0.00128, 0.01856 and 0.00321 respectively. On the other hand, the mean values of NFLR, CCR, ICR, and OSR are found before COVID-19 as 2.0936, 6.852, 0.9314 and 0.4751, and during COVID-19 as -2.5961, 5.879, 0.7673 and 0.3587 respectively. The findings construe a significant impact of the unprecedented pandemic. Within a short period of time, sample banks’ profitability and financial sustainability deteriorated significantly. A key implication of our study is that the private-sector commercial banks in Bangladesh experienced severe financial difficulties during COVID-19 which impacted their profitability and financial sustainability. The findings of the study suggest that adverse economic events have substantial effects on the financial realities of financial institutions. The findings of the study are expected to be useful to both academics and policymakers.
New Pixel
Authors: Joana Tavares
Published: April 2023

New Pixel é uma combinação de dois conconceitos drasticamente diferentes. "New", de Times New Roman, para as suas serifas e para a diferença do peso da linha – características tipográficas bastante clássicas. "Pixel", para as fontes pixelizadas que, embora apelem ao universo dos videojogos retro, continuam a ser fontes que representam a uma nova era digital e moderna.
Bolas
Authors: Figas
Published: April 2023

Bolas is a decorative display font that offers two weight options (Regular and Bold).
“I’m not getting paid to give you a TED talk on how my trans body works”. A qualitative study exploring healthcare encounters for hysterectomy as part of Female-to-Male gender affirming surgery
Authors: Filoche Sara , Ingamells Sarah , Steers Denise , Henry Claire , Hartley-Parsons Tai
Published: April 2023

Background: Healthcare for transgender people can be unsafe and
inequitable. Objectives: To explore the experiences of care
surrounding hysterectomy as part of female to male (FtM) gender
affirming surgery. Design: Qualitative observational study
Setting: Aotearoa/New Zealand Participants: Ten people
(out 12 people) who underwent FtM over a four-year period.
Results: No one person’s experience of the FtM journey was
affirming across the whole surgery journey. Transgender health literacy
was central to inclusive practice as it mediated bodily autonomy being
upheld. FtM (hysterectomy) surgery was described as “
life-saving”. The physical care environment influenced the
experience of the healthcare encounter. For example, the waiting room
was intimidating, with a gendered clinic name and toilets. Some
participants took a female support person/partner so that “
people looking would assume that I was there supporting her, not
the other way around.” Communication misalignments were evident around
information provided/understood about fertility and ovarian
preservation, requirement of a pre-operative pregnancy test, and
post-operatively, about bleeding and when sexual intercourse could be
resumed. Participants were also placed in the position of both receiving
care and providing education: “ I also shouldn’t have to be going
in there for treatment, and then being expected to educate the medical
professional that’s meant to be helping me… I’m not getting paid
to give you a TED talk on how my trans body works.”
Conclusions: A whole care pathway approach to increasing
transgender health literacy will facilitate better alignments in
communication, uphold bodily autonomy and lead to equitable inclusive
practice.
Analysis of respiratory virus detection in hospitalized children with acute respiratory infection during the COVID-19 pandemic in East China
Authors: Wu Ruoya , Zhang Jianwei , Liyan Mo
Published: April 2023

Objective During the COVID-19 pandemic, the adopted containment measures
have affected other respiratory virus epidemiology. Consequently, we
aimed to describe the characteristics of respiratory virus infection in
hospitalized pediatric acute respiratory infections (ARIs) patients
prior to and throughout COVID-19 in East China.   Methods Nasopharyngeal
secretions were collected from 9782 pediatric ARIs patients hospitalized
in Shaoxing Maternal and Child Health Hospital from January 2018 to
December 2022.  Changes in positivity viral detection rates and
epidemiological as well as clinical characteristics were analyzed and
compared. Results 1633 strains of 7 common respiratory viruses were
detected, with a total positive rate of 16.37% (821/5021) in 2018-2019
and 17.06% (812/4761) in 2020-2022.  Compared with 2018-2019, RSV
positive rate increased significantly in 2020-2022, while ADV, PIV-2,
PIV-3, and flu-B detection rates were significantly reduced (P
< 0.05).  The RSV-positive rate in winter increased
significantly more than in other seasons (P < 0.05), while
PIV-3 was mainly prevalent in spring and summer.   Conclusion During the
COVID-19 pandemic, there were significant age distribution and seasonal
differences in respiratory virus infection among hospitalized children
with ARIs in East China.
Spatio-temporal patterns of fine root distribution in four xerophytic species shifted by soil rock fragment contents
Authors: Hu Hui , Weikai Bao , Long Huang , Li Fanglan
Published: April 2023

Temporal and spatial distribution of fine root influences the potential
for resource acquisition in soil profiles, which defines how plants
interact with local soil environments; however, a deep understanding of
how vertical fine root distribution and their temporal dynamics varies
with soil structural variations is lacking. We subjected four xerophytic
species native to an arid valley of China, Artemisia vestita, Bauhinia
brachycarpa, Sophora davidii, and Cotinus szechuanensis, to increasing
rock fragment content (RFC) treatments (0%, 25%, 50%, and 75%, v
v-1) in an arid environment and measured fine root vertical profiles
over four years of growth. Fine root depth and biomass of woody species
increased with increasing RFC, but the extent of increase declined with
plant age. Increasing RFC also increased the degree of interannual
decreases in fine-root diameter. The limited supplies of soil resources
in coarse soils explained the increases in rooting depth and variations
in the pattern of fine root profiles across RFC. Fine root depth and
biomass of the subshrub species (A. vestita) in soil profiles decreased
with the increase in RFC and plant age, showing an opposite pattern from
the other three woody species. Within species, the annual increase in
fine root biomass varied with RFC, which led to large interannual
differences in the patterns of fine root profiles. Capacity of younger
or subshrub plants to cope with soil environmental changes were greater
than the older or shrub plants. These results provide insights into the
limitations of soil resources in dry and rocky environments, and have
management implications for degraded agroforest ecosystem.
Characteristics of SARS-CoV-2 Omicron BA.5 variants in Shanghai after ending the zero-COVID policy in December 2022: a clinical and genomic analysis
Authors: Liu Pengcheng , Cai Jiehao , Tian He , Li Jingjing , Lu Lijuan , Xu Menghua , Zhu Xunhua , Fu Xiaomin , Wang Xiangshi , Zhong Huaqing , Jia Ran , Ge Yanling , Zhu Yanfeng , Zeng Mei , Xu Jin
Published: April 2023

An unprecedented surge of Omicron infections appeared nationwide in
China in December 2022 after the adjustment of COVID-19 response policy.
In this study, we report the clinical and virological characteristics of
SARS-CoV-2 Omicron BA.5 infections among children in Shanghai during the
outbreak in late December 2022. We sequenced the 64 SARS-CoV-2 positive
samples obtained from hospitalized children. The genomic monitoring
revealed that the current outbreak was driven by the BA.5.2.48 and
BF.7.14 subvariants. Additionally, children with BA.5.2.48 infection
were more frequently observed to experience vomiting/diarrhea compared
to those with BF.7.14 infection. The high-frequency unique
non-synonymous mutations were present in BA.5.2.48 (N: Q241K) and
BF.7.14 (nsp2: V94I, nsp12: L247F, S: C1243F, ORF7a: H47Y) with respect
to their parental lineages. Of these mutations, C1243F mutation in S
protein, L247F mutation in nsp12, and H47Y mutation in ORF7a protein
were predicted to have a deleterious effect on the protein function.
Besides, H47Y mutation was also found to increase the stability of ORF7a
protein. Therefore, attention should be paid to these specific
mutations, especially for H47Y mutation, which could serve as a viral
immune escape strategy due to the potential immunomodulatory ability of
the ORF7a protein. Continuous genomic monitoring and clinical
manifestation assessments of the emerging variants will be crucial for
effective responses to the ongoing COVID-19 pandemic.
Tree biomass does not correlate with soil carbon stocks in forest-tundra ecotones along a 1100 km latitudinal gradient in Norway
Authors: Devos Claire , Ohlson Mikael , Næsset Erik , Klanderud Kari , Bollandsås Ole
Published: April 2023

Due to climate warming, forests are expanding to higher elevations and
latitudes at the expense of tundra vegetation. While the subsequent
increase in aboveground biomass is well-documented, there is much
speculation regarding the effects on soil organic carbon (SOC) stocks.
To provide insight into the consequences of tree encroachment into
treeless tundra, we sampled SOC stocks across 36 forest-tundra ecotones
along a 1100 km latitudinal gradient in Norway. Our results show that
SOC stocks vary greatly within, as well as among treeline ecotones, and
that tree biomass and tree species are not correlated with this
variability. Instead, SOC stocks increase with temperature, and vary
with slope steepness, slope aspect, and soil parent material. Applying a
‘space-for-time substitution’ perspective, our findings suggest that
tree encroachment into tundra is unlikely to have immediate consequences
for SOC stocks.
Strongyle Egg Reappearance Periods following Moxidectin Treatment in Horses in Southeast England
Authors: Mair Tim , Opie Rebecca , Moreton-Clack Michelle , Parkin Tim , Matthews Jacqui
Published: April 2023

Background: A reduction in the Egg Reappearance Period (ERP) has been
suggested to be an early indication of emerging anthelmintic resistance
in strongyles. Objective:To measure the strongyle ERP following
moxidectin treatment of horses in the southeast of England. Study
Design: Prospective study. Methods: Horses with a faecal egg count (FEC)
of > 400 strongyle eggs per gram (EPG) in a routine
screening sample were enrolled into the study. Moxidectin (400 mcg/kg)
was administered per os and FEC tests repeated every 2 weeks for 16
weeks. Results: Forty-eight horses completed the study. The mean EPG
prior to treatment was 1047 (range 375 – 2137 EPG). In all but two
horses, FEC was 0 EPG 2 weeks after moxidectin administration. In the
remaining two, the FECs were 12.5 EPG (97.8-98.3% reductions compared
to pre-treatment FEC). At 4 weeks post-treatment, 6 horses had positive
FECs (96.6-99.2% reductions). At 6 weeks, 11 horses had positive FECs
(83.8% reduction in one horse; >90% reduction in 10). At
8 weeks, 21 horses exhibited positive FECs (<90% reduction in
2). At 10 weeks, 27 horses had positive FECs (<90% in 6). At
12 weeks, 31 horses had positive FECs (<90% reduction in 11).
At 14 weeks, 34 horses had positive FECs (<90% reduction in
13). At 16 weeks, 38 horses had positive FECs (<90% reduction
in 17). Limitations: Weights of some horses were estimated using weigh
tapes rather than a weighbridge. Dosing of the horses with moxidectin
was carried out by owners. Conclusions: The results indicated acceptable
efficacy of moxidectin at 14 days after treatment; however, the ERP
pattern measured across the group suggest that this anthelmintic has a
considerably shorter suppressive effect on strongyle egg shedding than
measured when it was first introduced ( >13 weeks and up to
24 weeks).
UMP-CMP kinase 2 Inhibits ZIKV Replication through Activation of Type I IFN Signaling Pathway
Authors: Chen Limin , Zhu Ya , Shi Yaoqiang , Tan Qi , LI Shilin , Xie He , Li Bin , Duan Xiaoqiong
Published: April 2023

Abstract:Background: Cytidine/uridine monophosphate
kinase 2 (UMP-CMP kinase 2, CMPK2) has been reported as an antiviral
interferon-stimulated gene (ISG). We previously observed that the
expression of CMPK2 was significantly upregulated after Zika Virus
(ZIKV) infection in A549 cells. However, the role of CMPK2 in ZIKV
replication remains to be determined. Methods: CMPK2 or
retinoic acid inducible gene I (RIG-I) was overexpressed by plasmid
transfection or knocked down by siRNA, respectively in A549 cells before
the cells were infected with ZIKV. ZIKV RNA and NS1 protein were
detected by RT-qPCR and Western Blot, respectively. The activation
status of Jak-STAT signaling pathway was determined by the evaluation of
the phosphorylation level of STAT1 (p-STAT1, by Western Blot),
interferon stimulated response element (ISRE) activity (by dual
luciferase assay) and interferon stimulated gene (ISG) expression (by
RT-qPCR). Results: We found that ZIKV infection induced CMPK2
expression dependent on RIG-I. Overexpression of CMPK2 inhibited while
CMPK2 knockdown promoted ZIKV replication. Mechanically, we found that
CMPK2 inhibited ZIKV replication probably through the activation of
Jak/STAT signaling pathway as shown by the increased level of p-STAT1,
enhanced activity of ISRE, and the up-regulated expression of some
downstream ISGs. Conclusion: ZIKV infection induced CMPK2
expression, which activated the Jak/STAT signaling pathway to inhibit
ZIKV replication. Keywords: CMPK2; ZIKV; Jak/STAT signaling
pathway
Monomorphic Post-Transplant Lymphoproliferative Disorder in Pediatric Solid Organ Transplant Recipients: Treatment Approach Across Canada
Authors: Mark Catherine , Martin Gina , Baadjes Bjorn , Geerlinks Ashley V. , Punnett Angela , Lafay-Cousin Lucie
Published: April 2023

There are no standardized pediatric treatment protocols for monomorphic
post-transplant lymphoproliferative disorder (PTLD). We reviewed data
from Canadian pediatric centers to determine patient characteristics,
treatment approaches and outcomes. There were 55 eligible children
diagnosed with monomorphic PTLD between January 2001-December 2021.
Forty-nine (89%) underwent reduction of immunosuppression. The
majority, 44 (80%), received rituximab, 40/44 (91%) with concurrent
chemotherapy. A total of 46 (84%) children received chemotherapy:
LMB-96 (48%) and low-dose cyclophosphamide with prednisone (30%) being
the favored regimens. Projected 3-year event-free survival and overall
survival was 62% and 77%, respectively. Approach to monomorphic PTLD
treatment was relatively consistent across Canada.
TRANSIENT HYPERGLYCEMIA DURING ACUTE LYMPHOBLASTIC LEUKEMIA THERAPY: REVISITING RISK FACTORS AMONG INTERNATIONAL PROTOCOLS
Authors: Silva Lívia Cristina Oliveira e , Siviero-Miachon Adriana Aparecida , Sousa Ana Virgínia Lopes , Castro Angela Maria Spinola e
Published: April 2023

Background/Objectives: Transient hyperglycemia is an early
endocrine effect observed during ALL chemotherapy. The goal of this
study was to identify risk factors to hyperglycemia, compare data from
two international protocols, and perceive if its occurrence leads to
worse outcomes, such as infection, ALL relapse, or death.
Methods: Data refers to a cohort of 188 pediatric patients
undergoing ALL treatment at GRAACC/UNIFESP between 2004 and 2017. The
effect of individual characteristics (protocol treatment, gender, age,
ethnicity, family history of diabetes, puberty, nutritional status, ALL
cell lineage, and chromosome Philadelphia) on hyperglycemia development
was analyzed by univariate and multivariate logistic regression models.
The role of hyperglycemia as a risk factor for infection, ALL relapse,
and death was analyzed by ordinal logit regression, Fine and Gray
competing risks models, and univariate and multivariate Cox regression,
respectively. Results: The incidence of hyperglycemia was
43,6%. Puberty led to 7.9 greater risk for hyperglycemia (p=0.017). An
increase of one year of age led to a 14% reduction in the chance of
hyperglycemia among prepubertal individuals (p=0.039). The intermediate
risk for ALL relapse had 67% less chance for hyperglycemia than
high-risk patients (p=0.020). Hyperglycemia was not a risk factor for
infection during ALL treatment (p=0.840), for ALL relapse (p=0.302), or
for death (p=0.134). Conclusions: The identified risk factors
for hyperglycemia during ALL chemotherapy were: younger age, puberty,
and intermediate risk for ALL relapse. There was no difference in
hyperglycemia incidence between patients undergoing GBTLI-2009 or BFM
protocols. Hyperglycemia did not lead to worse outcome.
Several positive solutions to a nonlinear fractional differential equation together with the boundary conditions
Authors: Perween Gazala , Kumari Anita , Pati Smita
Published: April 2023

This paper deals with the study of existence of multiple positive
solutions to a type of nonlinear fractional differential equation D α (
y ) + p ( t ) f ( y ( t ) ) = 0 , t ∈ ( 0 , 1 ) , 1 < α ≤ 2
together with the boundary condition y ( 0 ) = 0 , y ′ ( 1 ) = 0 , where
D α represents the α-th order Riemann-Liouville type differential
operator. p( t) is a positive continuous function on
[0,1], and f:[0 ,∞)→[0 ,∞) is a continuous
function. We use Schauder’s fixed point theorem to obtain at least one
positive solution as well as we use Avery-Peterson fixed point theorem
to obtain at least three positive solutions. . AMS Subject
Categories: 34B18, 26A33 and 34B15.
Directional developable surfaces and their singularities in Euclidean 3-Space
Authors: Li Yanlin , Li Jing , Yang Zhichao , Abdel-Baky Rashad , Saad Mohamed
Published: April 2023

The developable surface is a surface that can be unfolded on a plane
without tearing or stretching, which is widely used in many fields of
engineering and manufacturing. This work presents a new version of
developable ruled surfaces in Euclidean 3-space. First, we establish an
adapted frame along a spatial curve, denoted by the quasi-frame. We then
introduce a parametric representation of a developable ruled surface and
call it a directional developable ruled surface. At the core of this
paper, we investigate the existence and uniqueness of such developable
surfaces, then study their classification by singularity theory and
unfolding method. Some examples are given in the final.
WHY IS THE INCIDENCE OF NON-CUTANEOUS MELANOMA HIGUER IN ASTURIAS THAN IN OTHER PARTS OF THE WORLD?
Authors: Luiña María Teresa Sotelo
Published: April 2023

This article presents data of incidence, cause, and other knowledge we
have about non cutaneous melanomas. What we found is that when analyzing
cases with this type of cancer in Asturias, the incidence is much higher
than what it is described in the literature for other parts of the
world. It is interesting because the study has been carried out in the
Central hospital of Asturias, it is the reference hospital in this
province of northern Spain. My opinion is that the life expectancy of
the region, combined with the lifestyle we have in Asturias, influences
these data in a very noticeable way.
Respiratory Culture Growth and 3-Year Lung Health Outcomes in Children with BPD and Tracheostomies
Authors: Steuart Rebecca , Pan Amy , Woolums Abigail , Benscoter Dan , Russell Christopher , Henningfeld Jennifer , Thomson Joanna
Published: April 2023

Background: While bacteria identification on respiratory
cultures is associated with poor short-term outcomes in children with
bronchopulmonary dysplasia (BPD) and tracheostomies, the influence on
longer-term respiratory support needs remains unknown.
Objective: To determine if respiratory culture growth of
pathogenic organisms is associated with ongoing need for respiratory
support, decannulation, and death at 3 years post-tracheostomy placement
in children with BPD and tracheostomies. Methods: This single
center, retrospective cohort study included infants and children with
BPD and tracheostomies placed 2010-2018 and >1 respiratory
culture obtained in 36 months post-tracheostomy. Primary predictor was
any pathogen identified on respiratory culture. Additional predictors
were any Pseudomonas aeruginosa and chronic P. aeruginosa
identification. Outcomes included continued use of respiratory support
(e.g., oxygen, positive pressure), decannulation, and death at 3 years
post-tracheostomy. We used Poisson regression models to examine the
relationship between respiratory organisms and outcomes, controlling for
patient-level covariates and within-patient clustering.
Results: Among 170 children, 59.4% had a pathogen identified,
28.8% ever had P. aeruginosa, and 3.5% had chronic P.
aeruginosa. At 3 years, 33.1% of alive children required ongoing
respiratory support and 24.8% achieved decannulation; 18.9% were
deceased. In adjusted analysis, any pathogen and P. aeruginosa
were not associated with ongoing respiratory support or mortality.
However, P. aeruginosa was associated with decreased risk of
decannulation (aRR 0.48, 95% CI 0.23-0.98). Chronic P.
aeruginosa was associated with lower survival probability.
Conclusion: Our findings suggest that respiratory pathogens
including P. aeruginosa may not promote long-term respiratory
dysfunction, but identification of P. aeruginosa may delay
decannulation.
Development and Evolution of Palmette Ornament: An Influence on Islamic Architecture
Authors: Zahra Fatima , Shahir Safrizal
Published: April 2023

Decorative architectural ornaments are the mainstay of several art forms. Islamic architecture had several properties and characteristics, including the non-depiction of living beings and emulating God's creation of wrongdoing. Therefore, floral, geometrical, and vegetal motifs became the main component of Islamic architectural ornaments. Similarly, Palmette is included and practiced on a large scale in Islamic architecture due to its vegetal or floral forms. This article focuses on the historical aspects of palmette ornament. Additionally, it explores the development and evolution of the ornament from west to east. Moreover, how palmette ornaments are practiced in Islamic Architecture. For this purpose, historical approach of description is used to explore and analyze the palmette ornament in depth.
Deoxysphingolipids – atypical skeletal muscle lipids related to insulin resistance in humans that decrease insulin sensitivity in vitro
Authors: Zarini Simona , Zemski Berry Karin A. , Kahn Darcy E. , Garfield Amanda , Perreault Leigh , Kerege Anna , Bergman Bryan C.
Published: April 2023

Sphingolipids are thought to promote skeletal muscle insulin resistance. 1-Deoxysphingolipids (dSL) are atypical sphingolipids that are increased in plasma of individuals with type 2 diabetes and cause β-cell dysfunction in vitro. However, their role in human skeletal muscle in unknown. We found that dSL species are significantly elevated in muscle of individuals with obesity and type 2 diabetes compared to athletes and lean individuals and are inversely related to insulin sensitivity. Furthermore, we observed a significant reduction in muscle dSL content in individuals with obesity who completed a combined weight loss and exercise intervention. Increased dSL content in primary human myotubes caused a decrease in insulin sensitivity associated with increased inflammation, decreased AMP-activated kinase (AMPK) phosphorylation, and altered insulin signaling. Our findings reveal a central role for dSL in human muscle insulin resistance and suggest dSL as therapeutic targets for the treatment and prevention of type 2 diabetes.
Prompt Assessment of Wire Ropes Technical Condition Based on Magnetic Testing Data
Authors:   INTRON PLUS, Ltd, Vorontsov A.N. , Volokhovsky V.Yu. ,   FGBOU VO NIU MPEI
Published: April 2023

A combined approach to the prompt analysis of technical condition of steel wire ropes of various functions is proposed. It is based on the bearing capacity (strength) criterion and the magnetic testing results. The principals are stated related to the strength assessment of degraded rope with measured local wire breaks and loss of metallic area due to corrosion (abrasion). After processing the received diagnostic charts the strength analysis is performed by means of appropriate mechanical model in terms of weak element hypotheses used in structure mechanics. Stress analysis gives the conservative strength estimates which will be referred to reliability margin. The stress safety factor is evaluated regarding the steady and cyclic loading. Because the measured data are of random nature and do not account for the distribution of faults at cross-section the statistical modeling of wear location over wires is performed. The total strength decrease is determined by superposition of strength reduction due to metallic area loss, and due to the wire breaks. Thus, the stress safety factor is considered as a probabilistic indicator of the state of the rope strength. The rope in service should be discarded if its stress safety factor becomes less than the empirical allowable strength factor which defines the rope margin of survival capability as a partially worn-out structure. Adjusted for regulatory disposal rules, three categories of worn rope condition are considered: serviceable, with a limited service life, and inoperative. These categories are presented by the green-yellow-red ranges at so-called «rope status map» in specified coordinates «Number of wire breaks — Loss of metallic section». The rope bearing capacity is promptly assessed by placing two mentioned testing data in corresponding position at the status map. An example is given related to the assessment of the status map for the load-carrying cable rod of the well pumping unit. Based on the obtained results the recommendations are formulated for application of the rope status maps as the templates for service personnel concerning further operation.
Acceptable Risk Criteria when Justifying the Safety of the Placement of Main Gas Pipelines within the Fifth Subzone of the Aerodrome Territory
Authors:   Rosaviatsiya, Averkiev A.A. , Churkin G.Yu. ,   ANO «Industrial Risk Research Agency», Talanova N.N. ,   ANO «Industrial Risk Research Agency», Sofyin A.S. ,   STC «Industrial Safety» CJSC
Published: April 2023

Issues of the safety of the placement of hazardous production facilities, in particular the main gas pipelines, within the boundaries of the fifth subzone of the aerodrome territory, as well as the possibility of applying a risk-oriented approach in justifying such placement, currently have a high degree of relevance. The review was carried out concerning the domestic and foreign approaches used in the field of ensuring the safety of the aircraft flights. At the same time, it was not possible to find studies devoted to assessing the impact of possible accidents at hazardous production facilities, located, or designed within the aerodrome territory, on the safety of aircraft flights. The present work was done to fill this gap. The following are proposed as key indicators of acceptable risk: the individual risk of death of passengers and crew members arising from accidents at hazardous production facilities within the fifth subzone of the aerodrome territory of the civil aviation aerodrome, and the expected number of deaths on board the aircraft as a result of such accidents during the year. The values of the acceptable risk criteria are assessed on the basis of the world experience in rationing risk indicators and, are also based on the open statistical data of domestic criteria for the safety of aircraft flights and air passengers applicable to the problem under consideration. The proposed set of criteria allows to link the methodology for ensuring the industrial safety of hazardous production facilities with the specifics of ensuring the safety of aircraft flights and the statistical accounting of aviation incidents and accidents. The need to develop a specialized calculation methodology for determining the actual values of risk indicators proposed as safety criteria is noted. The basic requirements related to this methodology are outlined in the paper.
Cost Effective Weather Monitoring Station
Authors: Al Rakib Md Abdullah , Samad MsT Fateha , Rahman Md. Moklesur , Abbas Fieid Ibna , Samad Mousume , Rahman Md. Ashiqur , Hossain Md. Miraj , Abbas Fysol Ibna
Published: April 2023

The system suggested in this study is a cutting-edge approach for tracking meteorological conditions in a specific location and making the data available elsewhere in the globe. The Internet of Items (IoT) is the technology underlying this, and it is a sophisticated and efficient method for connecting things to the internet and linking the entire universe of things in a network. Electronic devices, sensors, and vehicle electronic equipment might all be found here. The system uses sensors to monitor and regulate ambient factors such as temperature and relative humidity, and then sends the data to a web page, where it is plotted as graphical statistics. The data updated by the established system may be accessed over the internet from any location on the planet.
A pedagógusok önbevalláson alapuló digitális kompetenciaszintjének vizsgálata egy székelyföldi megyében a Covid-19 idején
Authors:   ", Tódor Imre ,   PhD, egyetemi adjunktus, Sapientia EMTE, Tanárképző Intézet, Csíkszereda,   igazgató, Sapientia EMTE PedPsi Kutatóközpont. E-mail: todorimre@uni.sapientia.ro"
Published: April 2023

"In our study, we are interested in the role of digital technologies in education and its inequality-forming/reducing effect, with a special focus on the social gap dimension of the phenomenon. In our study, we present the partial results of an empirical research among teachers in one of the counties of Szeklerland (Covasna), in which we compared the level of digital competence of teachers based on self-reflected data with social background variables such as gender, age, number of years in the profession, professional background, etc. The sample included teachers who had attended teacher training courses (N=312). The survey was conducted during COVID-19. Our results show that there are significant differences between users (teachers). Demographic indicators of teachers such as gender, age, type of workplace, location, etc. can be used to differentiate digital inequalities at the societal level. Keywords: teacher, COVID-19, social divide, digital divide, DigComp 2.1, DigCompEdu"