bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of a methylene blue and glyceryl trinitrate- based cream for the treatment of chronic anal fissures: a phase II randomized pilot trial from a referral coloproctological unit
Authors: Lobascio Pierluigi , Tomasicchio Giovanni , Cassetta Noadia , Altomare Donato Francesco , Gallo Gaetano , Pezzolla Angela , Laforgia Rita
Published: June 2024

BACKGROUND (MAIN AIM): Chronic anal fissures (CAFs) are the second most common anorectal disease. Non-surgical treatment includes several options with controversial efficacy. The aim of this study was to evaluate the efficacy and safety of a new ointment based on methylene blue in addition to glyceryl trinitrate. METHODS: A phase II randomized single-centre triple-blinded study was carried out in a tertiary proctology unit on patients with CAF. The enrollment started after local ethical approval (Study n.6461, Protocol approval n. 0045085). Eligible consecutive patients were randomized to create three different groups, each receiving a different ointment. The efficacy of the treatment was evaluated with the REALISE score. RESULTS: Nine patients with Cream A (median age 47 years, IQR 40–56, 22% female), nine with B (median age 52 years, IQR 49–57, 33% female), and nine with C (median age 58 years, IQR 46–62, 55% female). In group A, REALISE scores decreased significantly from a median of 22 (IQR 12–25) to 6 (IQR 4–8) (p < 0.05) after 40 days. In group B, REALISE scores improved significantly from a median of 20 (IQR 17–22) to 5 (IQR 4–9) (p < 0.05). In group C, REALISE scores decreased significantly from a median of 19 (IQR 19–20) to 4 (4–5) (p < 0.05). No statistically differences were recorded. The healing rate was 77% with Creams A and C, while it was 44% with Cream B. CONCLUSION: Methylene blue-based ointments could be a new and innovative treatment for the non-operative management and healing of CAFs.
A Two-Phase Approach for Solving the Multi-Skilled and Irregular Personnel scheduling Problem
Authors: Xue Ning , Bai Ruibin , Landa-Silva Dario , Cui Tianxiang , Jin Huan
Published: June 2024

In the realm of personnel scheduling, where demand is subject to variability, the creation of a work schedule for irregular worker presents a significant challenge. This difficulty is amplified when the specific shift types are not predefined and when workers possess varying levels of availability and distinct skill sets. Additionally, due to legal and cost constraints, personal preferences, and fairness considerations, the scheduling problem becomes even more complex. The typical personnel scheduling process generally consists of two main stages: shift design and shift assignment. During the shift design stage, a scheduler designs a set of shifts and calculates the required number of workers to meet the demand. The shift assignment stage involves allocating workers to each individual shift, while satisfying various constraints to achieve certain objectives.The shift design and assignment stages can be approached as a single problem or solved as two separate problems. In this paper, a two-phase method is investigated, where the first phase is addressed by an integer programming approach, and the second phase is solved using a memetic approach. Real-world retail store scheduling instances are used to test and compare these methods. The solution time and quality suggest that the proposed methods can be effectively applied to solve the irregular scheduling problem commonly encountered in retail stores.
Two-Stage Genetic Algorhitm for Optimization Logistics Network for Groupage Delivery
Authors: Malashin Ivan P. , Tynchenko Vadim S. , Masich Igor S. , Sukhanov Denis A. , Kudryavtsev Alexey A. , Ageev Daniel A. , Neluyb Vladimir A. , Gantimurov Andrei P. , Borodulin Alexey S.
Published: June 2024

This study explores groupage delivery optimization through a two-stage GA framework. The goal of optimization is to define locations of regional branch warehouses of Logistics Network to reduce transportation costs. The first stage of the GA focuses on identifying branch warehouses from a list of cities and uses the standard binary string approach, while the second stage solves Vehicle Routing Problem (VRP) using combinatorial GA. This research contributes to advancing logistics optimization methodologies and provides valuable insights for solving Location Routing Problem (LRP) which entails two problems: the Facility Location Problem (FLP) and the Multiple Vehicle Routing Problem (MVRP).
First record of Culicoides deltus as a putative vector of Onchocerca flexuosa in Slovak red deer (Cervus elaphus)
Authors: Kočišová Alica , Schreiberová Andrea , Kasičová Zuzana , Janošková Nikola
Published: June 2024

In the research conducted in years 2016–2022, 63,950 biting midges were trapped during 74 collections conducted in the area of Volovsky Mountains in Slovakia for the purpose of identifying the species composition, the host preference and the transmission or potential parasites in wild nature. The collected biting midges were of 29 species, while the most frequently detected were the Culicoides biting midges (C. obsoletus/C. scoticus/C. montanus), representing 47.9% of all biting midges. The species identification of biting midges was carried out based on their morphology and by applying molecular methods. The host preference of biting midges was molecularly identified by sequencing a 350-bp sequence of the mitochondrial cytochrome b gene (cyt b). The presence of Onchocerca flexuosa DNA in Culicoides deltus was confirmed by the sequencing of fragments of mitochondrial genes cox1. The sequences matched the previously published sequences for O. flexuosa. Data on high prevalence of infections caused by Onchocerca worms in red deer in Slovakia has already been published and indicates that there are favourable conditions for vectors and a suitable environment for parasite circulation in Slovakia. According to the authors’ knowledge, this was the first-ever detection of O. flexuosa in C. deltus in wild nature.
An Novel Efficient Bi-Objective Evolutionary Algorithm for Frequent and High Utility Itemsets Mining
Authors: Ma Li , Li Chongyang , Lu Hengyang , Fang Wei , Lin Jerry Chun-Wei
Published: June 2024

Mining frequent and high utility itemsets (FHUIs) from transaction database is an important task in data mining. In order to overcome the difficulties of parameter setting and huge search space in traditional algorithms for mining FHUIs, the task of mining FHUIs was modeled as a bi-objective problem and then solved by multi-objective evolutionary algorithms (MOEAs) in previous works. However, MOEAs may be inefficient when the number of transactions and items in the transaction database becomes large. To address this problem, we propose a novel efficient bi-objective evolutionary algorithm for mining FHUIs (NBOEA-FHUI). In NBOEA-FHUI, a novel initialization strategy is proposed, which takes the support, utility, and diversity of the initial population into account. The proposed initial strategy can make the initial population have relative high utility and support values with high population diversity. To improve the quality of the offspring, a method for estimating the support and utility value of itemsets and an offspring generation strategy are proposed in NBOEA-FHUI. The support and utility values of itemsets which are roughly proportional to their true values can be calculated by the estimation method with little computation. The proposed offspring generation strategy can generate better offspring based on the estimated support and utility value. Experimental results on several real datasets demonstrate that the proposed algorithm has better performance than the state-of-the-art MOEAs in terms of the convergence speed, search efficiency, and solution accuracy in the task of mining FHUIs.
Machine Learning for Groundwater Storage Prediction: Leveraging Climatic Variables
Authors: Md. Saleh , M. Rasel H.
Published: June 2024

Once abundant and readily available, groundwater (GW) is now dwindling at an alarming rate. This vital resource is under growing pressure from both natural and human-induced factors. Groundwater Level (GWL) is closely related to Groundwater Storage (GWS) thus the decline in GWL creates a shortage in GWS. This research developed a robust predictive model for GWS in Rajshahi district, Bangladesh, for the period 2001–2022 using six climatic variables, namely, Mean Temperature, Cloud Coverage, Humidity (percent), Solar Radiation, Sunshine, and Wind Speed. Three Machine Learning (ML)-based regression models- Random Forest (RF), Support Vector Machine (SVM), and Gradient Boosting Machine (GBM) were applied for this purpose. Results showed that the accuracy level was quite high while RF regression was plugged into the observed dataset (R2 = 0.80). Moreover, among the six climatic variables, cloud coverage, humidity, and wind speed contributed 87.4% altogether to predict the GWS. These findings offer valuable insights not only for understanding the GWS dynamics in Rajshahi district but also for informing sustainable management strategies. By providing decision-makers with a clear understanding of the key climatic drivers and their impact, this research empowers them to implement effective interventions and conservation measures to ensure the long-term availability of this critical resource.
Monitoring Long-term Cardiac Activity with Contactless Radio Frequency Signals
Authors: Chen Yan , Zhang Bin-Bin , Zhang Dongheng , Li Yadong , Lu Zhi , Chen Jinbo , Wang Haoyu , Zhou Fang , Pu Yu , Hu Yang , Ma Likun , Sun Qibin
Published: June 2024

Cardiovascular diseases claim over 10 million lives annually, highlighting the critical need for long-term monitoring and early detection of cardiac abnormalities. Existing techniques like electrocardiograms (ECG) and Holter are accurate but suffer from discomfort caused by body-attached electrodes. While wearable devices using photoplethysmography offer more convenience, they sacrifice accuracy and are susceptible to environmental interference. Here we present a radio frequency (RF)-based sensing system that monitors long-term heart rate variability (HRV) with clinical-grade accuracy. For the first time, our system successfully overcomes the orders-larger interference from respiration motion by overturning the conventional signal processing framework. By identifying previously undiscovered frequency ranges where heartbeat information predominates over other motions, we generate prominent heartbeat patterns with harmonics typically considered detrimental. Extensive evaluations, including a large-scale clinical setting involving 7,090 participants and a long-term daily scenario spanning two months, demonstrate that our system can monitor HRV and diagnose abnormalities with comparable performance to clinical-grade ECG-based systems. This RF-based HRV sensing system has the potential to support active self-assessment and revolutionize medical prevention with long-term and precise health monitoring.
Tax impacts on MNE investment: evidence for cross-border relocation
Authors: Hanappi Tibor , Whyman David
Published: June 2024

Multinational enterprises (MNEs) differ from other corporations—domestic groups or standalone entities—in various ways. Their organizational structures span large numbers of jurisdictions, which is likely to affect how they react to country-specific changes in taxation. We investigate MNE investment responses to taxation within and across a large number of countries using MNE entity- and group-level data. Our results show that MNE tax responsiveness is distinctively heterogenous within countries and that there are investment spillovers to and from countries that did not experience a tax change themselves, confirming the specific nature of MNE investment responses to taxation. Furthermore, it suggests that tax increases at host jurisdiction level may not lead to statistically and quantitatively significant investment responses at the MNE group level, while showing some evidence of positive cross-border tax effects on investment by entities in other jurisdictions within the same MNE group. This finding suggests that the well-document negative relationship between taxation and MNE investment within a host jurisdiction might partially mask the MNE rebalancing the location of its investment to other host jurisdictions in response to changes in cross-jurisdictional tax rate differentials rather than purely decreasing its investment globally.
Lived Experience of Comfort on Sexuality and Fertility for Survivors of Hematopoietic Stem Cell Transplants: Phenomenological Study
Authors: BACALHAU Lúcia , PONTÍFICE-SOUSA Patrícia
Published: June 2024

Purpose: To grasp the scope of sexuality and fertility within the lived experiences of comfort and discomfort among allogeneic stem cell transplant survivors.
Methods: We employed a qualitative approach through van Manen's phenomenology of practice. The phenomenon was revealed via phenomenological interviews, incorporating narratives and illustrative episodes that captured the lived experiences of 20 survivors. We gathered descriptions of these experiences from participants from July 2020 to May 2021. During our phenomenological reflection on these accounts, we adhered to stages like epoché, reduction, and vocative, as outlined by van Manen (1).
Results: The exploration of comfort within the realms of sexuality and fertility yielded several themes: desire and the relationship; immunosuppression as a limitation on sexual activit; the body does not correspond to desire; the future: fertility and the couple's relationship; the challenges of disclosure and intervention.
Conclusion: The findings indicate that survivors have long-term challenges with sexual expression and activity, stemming from the physical constraints of GVHD, perceptions of their immunosuppression, and the significance of their partnership, all of which translate into requirements for nursing care.
Implications for Cancer Survivors
Considering the experiences of these participants and the observed comfort linked to the sexuality of AHSCT survivors, we can contemplate the care practices and recognize sexuality as a field of action for nurses in this context to enhance comfort for these individuals.
Identification and validation of an invasion-related disease-free survival prognostic model for tongue squamous cell carcinoma
Authors: Fang Wei , Wan Di , Peng Yanhui , Yang Xiaoqin
Published: June 2024

Background:
Tongue squamous cell carcinoma (TSCC) a common malignant tumor type, with aggressive invasion and poor prognosis. To date, invasion-related gene expression signatures for the prognostic stratification of TSCC patients are unavailable in clinical practice. This study aimed to assess the impact of invasion-related genes on the prognosis of TSCC patients.
Methods:
We obtained the mRNA profiles and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases (TCGA-TSCC and GSE41116, respectively). The TSCC samples from the TCGA-TSCC cohort were randomly divided into TCGA training and TCGA test datasets at a 7:3 ratio. Next, a disease-free survival (DFS) prognostic risk model was established based on univariate and stepwise multivariate Cox regression analyses of TCGA training cohort. Moreover, prognostic genes were screened. Then, the model was evaluated and validated using the TCGA test and GSE41116 datasets. In addition, the prognostic genes were validated in the human TSCC cell line UM1 and the human oral keratinocyte (HOK) cell line using qRT‒PCR analysis.
Results:
Atotal of 70 candidate genes related to invasion were identified in TCGA-TSCC. DFS data were subsequently constructed, and 6 prognostic genes, HMGN2, MYL12B, ACTB, PPP1CA, PSMB9, and IFITM3, were identified. The TSCC samples were divided into high- and low-risk groups in the TCGA training, TCGA test, and GSE41116 cohorts, separately. In particular, the patients with TSCC in the low-risk group had longer disease-free survival (DFS) than those in the high-risk group. Furthermore, qRT‒PCR analysis confirmed that the expression levels of the 6 prognostic genes were significantly greater in the TSCC cell line UM1 than in the HOK cell line.
Conclusion:
This study identified new invasion-related target genes related to poor prognosis in TSCC patients, providing new insights into the underlying mechanisms of TSCC invasion.
Preparation of a novel Ag3PO4/Bi-MOF heterojunction photocatalyst for the degradation of organic pollutants under visible light irradiation
Authors: Ji Yufeng , Zou Congyang , Wang Yong , Zhou Zhuyou , Liu Menghe , Xu Ying , Liu Ruijie , Yang Mingjie
Published: June 2024

In this study, a novel photocatalyst composed of Ag3PO4 and Bi-MOF was synthesized via chemical precipitation at room temperature. The morphology, chemical composition, and molecular structure of the composite materials were characterized using SEM, XRD, FTIR, XPS, and various other analytical techniques. Photocatalytic activity of the samples was evaluated by degrading tetracycline hydrochloride and rhodamine B. The composite materials exhibited significantly enhanced photocatalytic activity compared to pure Bi-MOF and Ag3PO4, with APBM-1/1 performing the most effectively. The degradation rates of rhodamine B (RhB) and tetracycline hydrochloride (TCH) were 99% and 86.9% within 50 min and 30 min of light exposure, respectively. The possible mechanisms of photocatalytic degradation of pollutants were proposed by electron paramagnetic resonance (EPR) and capture experiments. The construction of a type-II heterojunction interface between Ag3PO4 and Bi-MOF accelerated the efficiency of the interfacial charge separation, which resulted in excellent photocatalytic activity.
Comparison of seaweed species composition and coverage of Sargassum and Myagropsis communities between artificial and natural reefs in Wakasa Bay, Japan
Authors: Matsui Akira , Kawamura Masakatsu , Nozawa Shigehiro , Takeyama Masatomo , Inoue Naoya
Published: June 2024

The threat of declining seaweed beds has been a concern around the world. Seagrass and seaweed (brown algae) beds are essential habitats supporting fisheries. However, approximately 22% of these habitats have been lost in Japan due to increased coastal landfill sites and ports. This study aims to rehabilitate the depletion of these habitats by constructing an artificial reef in Wakasa Bay, Japan, and monitoring brown algae (Sargassum and Myagropsis) succession in 2 years and 4 years after the construction was completed. In this study, we set up five sites on the artificial reef as a treatment area and one site on the natural reef as a control area and then identified the seaweed species composition of the Sargassum and Myagropsis communities and their coverage on each reef using underwater visual observation by scuba divers. The seaweed coverage on the artificial reef was already close to that on the natural reef in 2 years after construction. However, the dominant species on the artificial reef was not conformable to that on the natural reef in 2 years after construction. The dominant species on the artificial reef changed to S. horneri/S. confusum in 2 years after construction and M. myagroides in 4 years after construction. On the other hand, the dominant species on the natural reef changed to S. patens in 2 years after construction and M. myagroides in 4 years after construction. That is, the species composition on the artificial reef was close to that on the natural reef in 4 years after construction. Thus, the recovery of species composition takes longer than that of seaweed coverage on the artificial reef.
Properties of particle board and briquette from Lantana camara: A path to Adaptive Management
Authors: Ramkumar V. R. , Thanigai K. , Ram Ritesh Kumar , Murali G. , Prakash V. , Gautam Veer Singh , murthy Narasimha , Ranjan Manish
Published: June 2024

This study explores the potential of Lantana camara (LC), a weed eradicated from forest and non-forest areas, for developing particle boards and value-added products. The study was conducted in four stages; the initial stage involved an examination of the anatomical characteristics of Lantana sticks to assess their industrial suitability. In the second stage, the study focused on investigating the physical and mechanical properties of Lantana sticks. In the third stage, particle boards with a thickness of 19 mm were manufactured, employing urea-formaldehyde as a binder. A comprehensive evaluation was carried out to assess various characteristics of the board, including modulus of elasticity, modulus of rupture, thickness swelling, water absorption, density, internal bond strength, and screw withdrawal. Additionally, a comparative study was undertaken to assess the variability and performance of particle boards made from wood (Melia dubia). In the final stage, the study investigated the development of briquettes from LC. A thorough analysis of fuel properties was conducted, including calorific value, proximate and elemental analysis, ash elemental analysis, density, and energy density of LC biomass. LC exhibits a composition characterized by 25% lignin and 65% cellulose. Additionally, the cellular characteristics of LC, including the number of cells per ray and the cell frequency, were observed to be 12.5 and 4.6/mm, respectively, resembling those of Melia dubia. Moreover, both LC (shrub) and Melia dubia (hardwood) demonstrated comparable basic densities, falling within the range of approximately 410–550 kg/m³ for LC and 481–501 kg/m³ for Melia dubia.
Research and Application of Adaptive Projection Map Matching Algorithm under the Background of Complex Roads
Authors: fu xiaoxue , cheng hongtao , chen yijin
Published: June 2024

To address the problems of easy volatility, empty matching, incorrect matching, and low matching accuracy, an adaptive projection map matching algorithm is proposed based on existing map matching algorithms for intersecting urban roads. First, the method of setting the distance threshold was used to eliminate abnormal location points. Then, by comparison with the AutoNavi map, the missing data in the OpenStreetMap were filled. To reduce the matching time, the grid index was generated, and the impossible methods were filtered by the error circle. Second, the probabilities of the projection distance and direction were assigned, and the corresponding weight coefficients were adjusted adaptively. Finally, the probabilities of the candidate methods were calculated by considering both the projection distance and direction, which helped to determine the actual road and improve the matching accuracy. At the same time, real-time driving data from Changzhou taxi vehicles were used for experimental verification. The results show that the adaptive projection map matching algorithm can increase the matching accuracy by approximately 4% compared with other existing matching algorithms and shorten the single-point matching time by approximately 1.5 ms, which realizes accurate map matching under complex intersecting methods.
Virtual screening, XGBoost based QSAR modelling, Molecular Docking and Molecular Dynamics Simulation approach to discover a new inhibitor targeting ErbB1 Protein
Authors: Bouchama Fateh , Kraim Khairedine , Brahimi Mohammed , Saihi Youcef , Mezghiche Karima , Nacereddine Abdelmalek Khorief , Djerourou Abdelhafidh , Taha Mutasem Omar
Published: June 2024

ErbB1 is a protein found on certain types of human cells that binds to a substance called epidermal growth factor (EGFR). The ErbB1 protein is involved in cell signalling pathways that control cell division, proliferation, and survival. Sometimes, mutations in the EGFR gene cause ErbB1 proteins to be made in higher-than-normal amounts on some types of cancer cells. The aim of this study is using the virtual screening based on ligand and structure drug design using respectively QSAR, molecular docking & molecular dynamics simulations approaches to identify novel antitumor small molecules. Therefore, the QSAR model was developed and validated using XGBOOST as a learning algorithm classifier trained on 5215 compounds. The validated model is used for screening of more than 80k natural products downloaded and prepared from the ZINC database to offer us only 36 as potent predicted inhibitors against ErbB1. The selected active compounds were docked against the target represented by the PDB ID: 3POZ. The obtained top five scoring compounds were compared to the reference ligand TAK285, to the Lapatinib and the Erlotinib drugs, after this phase their stability into the ErbB1 protein binding site has been validated using the molecular dynamics simulation.
A Novel Method for Maintaining Low and Constant Salinity in Ice During Desalination of Binary Mixtures Using Directional Solidification
Authors: Kumar Virkeshwar , Kumar Narendra , Sarawagi Radhika
Published: June 2024

Water scarcity is a global issue worsened by population growth, climate change, and industry. Freezing-based desalination shows potential with lower energy needs and less environmental impact. However, current freezing methods produce ice with inconsistent salt levels, and new solutions are needed. This paper proposes a novel method inspired by directional solidification principles to achieve uniform low salinity in ice formation. This study investigates the efficacy of directional solidification techniques for desalination, contrasting them with conventional top cooling methods. Three distinct setups were employed: Setup_1 utilized top cooling, while Setups 2 and 3 incorporated directional solidification akin to the Bridgman and Czochralski methods. The conventional approach often leads to non-uniform salinity distribution within ice structures due to complex convection phenomena, whereas directional solidification ensures consistent salinity throughout the ice volume. Experimental results demonstrate uniform salinity levels along the lengths of water solutions, measuring 0.34±0.04 wt% NaCl for 1.7 wt% NaCl water and 0.7±0.05 wt% NaCl for 3.4 wt% NaCl water. In multistaging desalination, this saline ice again melts and is further desalinized using the same leads to 0.1±0.05 wt% NaCl, which can be directly used for the drinking stage. Additionally, energy consumption analysis reveals directional solidification’s potential for significant energy savings, with around a 5% reduction observed compared to conventional methods for single-stage desalination. This study marks the initial exploration of desalination via directional solidification, suggesting avenues for further investigation, particularly concerning energy optimization through numerical simulations.
Vergleich der Kongruenz von „Field of View“ (FOV) und der „Region of Interest“ (ROI) von DVT-Aufnahmen mit geräteseitig vordefinierten FOV-Einstellungen
Authors:   , Marzouq Muntazer
Published: June 2024

Diese Arbeit hatte das Ziel, die Größe einer DVT-Aufnahme (FOV) mit der Größe der durch die Indikationsstellung definierten Region (ROI) zu vergleichen. Durch eine speziell dafür entwickelte Software sollten Messungen in den Datensätzen ermöglicht werden. Die dazu verwendeten 332 Datensätze wurden zufallsverteilt aus den mit einem Orthophos SL-3D DVT-Gerät der Firma Dentsply Sirona in der Poliklinik für zahnärztliche Chirurgie und Implantologie des ZZMK (Carolinum) in Frankfurt angefertigten Röntgenaufnahmen selektiert. Es wurde die Auswertungssoftware ExRoi entwickelt, mit der die Werte des axialen Durchmessers, die Höhe (vertikale Dimension) sowie die Distanz der Mittelpunkte von FOV und ROI direkt in den Datensätzen bestimmt werden konnten. Zusätzlich wurde festgehalten, welche rechtfertigenden Indikationen gestellt und welche Auflösungsmodi verwendet wurden. Die Stichprobe bestand aus Aufnahmen mit einem axialen Durchmesser von 8 cm [VOL 1] (n= 76, entsprechend 46,39%), 5 cm Durchmesser [VOL 2] (n = 102, entsprechend 30,72%) und 11 cm Durchmesser [VOL 3] (n= 154, entsprechend 22,89%). 95,18% der Aufnahmen wurden im HD-Modus mit laut Herstellerangaben vier Mal so vielen Aufnahmen im Vergleich zum SD-Modus angefertigt. Hauptindikationen waren Implantat Planung (45,1%) und Planungen komplizierter Zahn-Extraktionen (25,5%). Die Messungen zum Vergleich des axialen Durchmessers zeigten, dass bei Verwendung des VOL 2 die ROI im Mittel den größten Anteil der FOV nutzt (78,52 %), den kleinsten Anteil nutzt durchschnittlich VOL 1 (56,04 %). Dazwischen liegt VOL 3 (69,12 %). In der Vertikalen nutzt die ROI von VOL 3 mittelwertig den größten Anteil der FOV (81,87 %), den kleinsten Mittelwert hat VOL 1 (58,76 %). VOL 2 liegt zwischen diesen Werten (64,47 %). In allen Fällen war das FOV größer als die ROI und die ROI lag im Bereich des gewählten FOV. Die Mittelpunkte von FOV und ROI lagen im Mittel in der axialen Ebene in Abhängigkeit vom gewählten Volumen um rund 9-13 mm auseinander, in der coronalen und sagittalen Ebene um rund 5-6mm. Aus diesen Ergebnissen kann für das verwendete Gerät eine gute Trefferquote für die ROI abgeleitet werden. Höhe und Durchmesser des FOV hätten in den meisten Fällen kleiner gewählt werden können, liegen aber angesichts der vorhandenen Auswahl-Optionen des Röntgengeräts zur Dimensionierung der Volumina in einem akzeptablen Bereich.
Einfluss von Interaktionsdatenbanken auf die Arzneimitteltherapiesicherheit im Krankenhaus
Authors:   , Ilgner Liv Frederike
Published: June 2024

Die Ergebnisse der Studie und die Diversität der Datenbanken ist groß. Für 12 Datenbanken wurde ein Punktesystem mit elf Items entworfen, um die Qualität der einzelnen Datenbanken zu objektivieren. Keine Datenbank konnte alle Bewertungskriterien erfüllen. Der insgesamt schlechte Punktedurchschnitt ist ein Indikator für die Mängel der aktuell verfügbaren Datenbanken. Außerdem konnten wir einen Qualitätsunterschied zwischen kostenpflichtigen und kostenfreien Datenbanken beweisen und mussten im Zuge dieser Ergebnisse die Frage stellen, ob kostenfreie Datenbanken überhaupt nützlich sind. Zwischen den kostenpflichtigen Datenbanken fallen die Qualitätsunterschiede weniger gravierend aus, wenngleich Stärken und Schwächen sich deutlich unterscheiden. Die häufigsten Wechselwirkungen wurden in allen Datenbanken mit großem Abstand zwischen rein psychiatrischen Interaktionspaaren erfasst. Dieses zeigt, wie wechselwirkungsreich Psychopharmaka sind und dass psychiatrische Patienten besonders vulnerabel sind. Die Nutzung digitaler Hilfsmittel scheint bei Betrachtung der hohen Anzahl ausgegebener Warnmeldungen unabdingbar zu sein, dennoch existiert große Uneinheitlichkeit bei der Bewertung der einzelnen Interaktionen. Die Vorstellung, dass zwei Kliniker bei Nutzung zweier unterschiedlicher Datenbanken zu völlig unterschiedlichen Empfehlungen kommen, fällt nicht schwer. Gleichzeitig könnte die Kooperation von Heilberuflern, die unterschiedliche Datenbanken verwenden, die Chance auf zusätzlichen Informationsgewinn und Austausch erhöhen, was im Umkehrschluss in einer erhöhten Arzneimitteltherapiesicherheit resultiert. In Studien konnte der positive Effekt interdisziplinärer Zusammenarbeit bereits bewiesen werden. Zusammenfassend konnten umfangreiche Differenzen zwischen allen untersuchten Datenbanken aufgezeigt werden. Um den Anforderungen des klinischen Alltags zu genügen, müssen digitale Unterstützungssysteme weiterentwickelt werden. Die „ideale Datenbank“ gibt es bisher nicht – das lässt sich durch unser Punktesystem beweisen. Um im klinischen Alltag Patientensicherheit zu gewährleisten ist die Nutzung einer einzelnen Datenbank bisher nicht ausreichend. Die Gewährung der Patientensicherheit sollte unser oberstes Ziel sein und um dieses zu erreichen, bedarf es vieler Komponenten. Neben der Nutzung und vor allem Weiterentwicklung digitaler Unterstützungssysteme sollte auch der zwischenmenschliche Austausch weiter gefördert werden. Interdisziplinäre Zusammenarbeit im Sinne pharmazeutischer Dienstleistungen zur Medikationsanalyse könnten ein zusätzliches Instrument zur Vermeidung arzneimittelbezogener Probleme werden. Zukünftig werden unsere Patienten am meisten von optimaler Nutzung weiterentwickelter Technologien, sowie wachsendem zwischenmenschlichem Austausch profitieren.
Temporal Separation of Red and Blue Photons Does Not Increase Photon Capture or Yield of Lettuce
Authors: Liu Jun , Bugbee Bruce
Published: June 2024

Temporal separation of red (R) and blue (B) (alternating R/B) photons has been reported to increase leaf area, photon capture, and yield of lettuce compared with delivering both colors together (concurrent R+B). We grew three diverse lettuce cultivars (Grand Rapids, Rex, and Red Sails) under concurrent R+B photons (9/1 ratio) and alternating R/B photons (9/1 ratio) under an equal daily light integral (DLI) of either 8.6 or 23 mol⋅m−2⋅d−1. Contrary to five previous studies, we found no increase in either leaf area or fresh mass and dry mass in any of the alternating R/B photon treatments compared with concurrent R+B photons. In fact, at a DLI at 8.6 mol⋅m−2⋅d−1, alternating R/B photons decreased the dry mass of ‘Grand Rapids’ and ‘Rex’ lettuce by 38% and 17%, respectively. Two previous studies reported that photosynthetic rates increased with alternating R/B photons; however, we found that the net assimilation rate was generally decreased by alternating R/B photons. An analysis of images obtained from automated digital photography revealed that the relative expansion rate of leaves was 61% higher during intervals of pure B rather than intervals of pure R photons at the same photosynthetic photon flux density; however, this did not result in a higher leaf area compared with concurrent R+B photons. Overall, our studies do not indicate that alternating R/B photons increase lettuce leaf area or yield compared with concurrent R+B photons.
Exploring Students’ Perception of Quizizz as a Learning Media in Higher Education
Authors: Sitompul Harun , Sayekti Retno , Saragih Sri Rahmah Dewi , Salminawati
Published: June 2024

The use of game in education has been evidenced to improve students’ engagement in learning. However, much research shows that the use of game in learning is only effective for high school students, while its use for students of higher education is limited. Research on game in education has predominantly been occupied by Kahoot! while Quizizz has received less analysis. This research aims to explore student perception of Quizizz as a learning media and the related obstacles experienced in a library science study program of State Islamic University of North Sumatera in Indonesia. The research uses a combination of quantitative and qualitative methods, such as survey and focused group discussion, with a sample of 272 undergraduate students. The study found that the use of games in learning actively increased student engagement and led to a significant improvement in independence and self-control in learning. During the learning activity students maintain that they gain their self-confidence while enjoying the game. The research suggests that to increase learning achievement, educators should use various teaching strategies that encourage students’ active mental and physical engagement. Additionally, it is expected that this learning experience and content will enhance students' retentive memory.
Generative invertible quantum neural networks
Authors: Rousselot Armand , Spannowsky Michael
Published: June 2024

Invertible Neural Networks (INN) have become established tools for the simulation and generation of highly complex data. We propose a quantum-gate algorithm for a Quantum Invertible Neural Network (QINN) and apply it to the LHC data of jet-associated production of a Z-boson that decays into leptons, a standard candle process for particle collider precision measurements. We compare the QINN’s performance for different loss functions and training scenarios. For this task, we find that a hybrid QINN matches the performance of a significantly larger purely classical INN in learning and generating complex data.
RAPIDLY INVOLUTING CONGENITAL HEMANGIOMA SIMULATING CONGENITAL SARCOMA.
Authors:   Service de Dermatologie et de Venerologie., Baybay H. , Dahmani B. ,   Service de Dermatologie et de Venerologie., Boularbah S. ,   Service de Dermatologie et de Venerologie., Elloudi S. ,   Service de Dermatologie et de Venerologie., Soughi M. ,   Service de Dermatologie et de Venerologie., Douhi Z. ,   Service de Dermatologie et de Venerologie., Maaroufi M. ,   Service de Radiologie CHU Hassan II - Fes., Rimani M. ,   Service Danatomie Pathologique HASSAN Rabat., Mernissi FZ. ,   Service de Dermatologie et de Venerologie.
Published: June 2024

Rapidlyinvolutingcongenitalhemangiomaisararevasculartumorthat generally has a good prognosis.we report the case of a newborn boy witha left temporalvascular lesion. Ulcerationand bleeding are rarely reported in rapidly involuting congenital hemangioma, We describe a case of a newborn boy who presented with rapidly involuting congenitalhemangioma complicated by ulceration and bleeding Suggesting diagnosis of congenital sarcomawhich was ruled out byskin biopsy.
Role of artificial intelligence for strengthening human resource system via mediation of technology competence
Authors: Al-Ayed Sura
Published: June 2024

This study aims to investigate the relationships between artificial intelligence in human resources (HR), technology competence, and HR system strength within organizations. Employing a cross-sectional methodology, survey data were collected from 272 employees working in HR departments in the private sector of Saudi Arabia. Partial least squares structural equation modeling was utilized for analysis to evaluate these relationships. The results indicate a significant positive relationship between artificial intelligence in HR and both technology competence (β = 0.444, p < 0.001) and HR system strength (β = 0.539, p < 0.001). Additionally, there is a positive impact of technology competence on HR system strength (β = 0.272, p = 0.021). These findings underscore the importance of investing in AI technologies and enhancing employees’ technological skills to improve HR system effectiveness. Furthermore, the study emphasizes the necessity for organizations to prioritize agility and adaptability in HR strategies while addressing ethical and social considerations surrounding AI in HR practices. Moreover, the study elucidates the role of artificial intelligence in fostering innovation and sustainability within HR practices, contributing to organizational resilience and competitiveness.
AcknowledgmentThe author extends her appreciation to the Arab Open University for funding this work through Research Fund No. (AOUKSA-524008).
Audiovisuais Ecosóficos: A educação ambiental através de telas
Authors: Marques Rodrigo Müller , Mazzarino Jane
Published: June 2024

Este estudo trata de um processo de formação de professores em Educação Ambiental, por meio da construção de audiovisuais socioambientais. As Tecnologias de Informação e Comunicação (TICs), foram usadas em uma experiência de educomunicação socioambiental com uso e produção de audiovisuais perpassada pela perspectiva da ecosofia, a qual propõe a criação de novos territórios existenciais a partir da interação entre o eu, o nós (socius) e o ambiente. Tem-se por objetivo deste estudo analisar produções audiovisuais socioambientais ecosóficas e suas potências para a efetivação da EA. A metodologia de pesquisa, caracteriza-se como qualitativa e bibliográfica, ancorada na pesquisa-ação com observação participante. Como procedimentos técnicos para a produção de dados, utilizaram-se diários de campo, gravações em áudio e transcrições de encontros realizados com professores, além de análises etnográficas dos dois audiovisuais produzidos durante a formação de quatro professoras de diferentes níveis e redes da Educação Básica. Os resultados demonstram que audiovisuais socioambientais constituem-se em uma estratégia para a reinvenção dos modos de fazer educação ambiental no espaço escolar e a ecosofia, enquanto pano de fundo, fornece diversas possibilidades para os diferentes fazeres da Educação Ambiental.
Atribuições causais para resultados acadêmicos e seus impactos diferenciais sobre os hábitos de estudo de estudantes universitários
Authors: De Souza Jerson Sandro Santos , Mascarenhas Suely Aparecida do Nascimento
Published: June 2024

O presente estudo tem por objetivo analisar como as atribuições causais para resultados acadêmicos interferem nos hábitos de estudo de estudantes do ensino superior. Para tanto, empreendeu-se uma pesquisa descritiva, correlacional e de enfoque quantitativo. Participaram do estudo 102 estudantes de graduação e pós-graduação. Os dados foram coletados por meio de duas escalas do tipo Likert e analisados de acordo com procedimentos da estatística descritiva e inferencial. Os resultados indicam que as diferentes atribuições causais referentes a resultados acadêmicos impactam de modo diferencial os hábitos de estudo e o desempenho acadêmico de estudantes do ensino superior, sendo que as atribuições causais mais adaptativas (internas, instáveis e controláveis), relativas tanto ao bom como ao fraco desempenho acadêmico, relacionam-se aos melhores indicadores de hábitos de estudo e de desempenho acadêmico geral. Também foram discutidas as implicações dos achados para programas de apoio psicopedagógico ao processo de estudo-aprendizagem no ensino superior.
Monitoring Pesticide Residues in Anuran Liver Tissue: A Proposal for the Sample Preparation Method
Authors: Lima Igor , Santos Allyson , Vieira Andressa , Gondim Patrícia , Cascon Paulo , Faria Anizio
Published: June 2024

In this work, a miniaturized version of the QuEChERS (quick, easy, cheap, effective, rugged, and safe) method was optimized, validated, and applied for extracting eight pesticide residues in anuran liver tissue samples. The extracts were quantified by high-performance liquid chromatography with diode array detection, and the detected residues in liver tissue samples were identified by tandem mass spectrometry-liquid chromatography. The optimized extraction method entailed the scale reduction of the QuEChERS method twenty times using 500 mg of liver tissue sample, 200 mg Mg2SO4, 50 mg NaCl, 1.5 mL of acetonitrile, and a mixture of 25 mg C18 + 25 mg PSA (primary-secondary amine) as dispersive solid-phase extraction sorbent. The method was validated using liver tissue samples spiked at two levels of pesticide concentrations according to the SANTE/11312/2021 document. Recoveries ranged from 91-110% with a relative standard deviation < 20%. The method robustness assessed by the Steiner and Youden test resulted in recovery rate variations of less than 2% for all pesticides after deliberated changes in seven variables. The validated method was applied to 72 liver tissue samples from two anuran species, registering residues of some pesticides in 31 samples. The proposed method proved to be efficient, precise, and robust for determining pesticide residues in anuran liver tissues.
A Case of Parotid Mucoepidermoid Carcinoma Recurring along the Mask Strap Line
Authors: Whangbo Chang Ho , Yoo Jae Ho , Kim Jeong Kyu , Lee Dong Won
Published: June 2024

Mucoepidermoid carcinoma is one of the most common malignant tumors that occur in the salivary glands. While several cases of distant metastasis have been reported, instances of metastasis to the skin are rare. We present the case of a 72-year-old man diagnosed with parotid mucoepidermoid carcinoma who experienced temporary remission following surgical resection and adjuvant chemoradiotherapy. However, the carcinoma recurred along the skin at the periauricular area along the mask line. Given the current prevalence of COVID-19, the practice of wearing masks has become more widespread. This case report highlights the recurrence of mucoepidermoid carcinoma along the mask strap line, emphasizing the importance of distinguishing it from benign dermatological conditions.
Dermatofibrosarcoma Protuberans on the Occipital Scalp Showed Uncommon Presentation: A Case Report
Authors: Jeong Jiwon , Chung Chul Hoon , Cho SeongJin
Published: June 2024

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma, with an incidence of about 0.8% to 5% per million people per year, accounting for 1% of soft tissue sarcomas. In its early stage, DFSP is typically found as a violet or pinkish macule or patch, and it can develop into a palpable mass with ulceration or bleeding. The standard treatment for DFSP is wide local excision of the tumor with a 2- to 3-cm negative margin, and radiation therapy or chemotherapy can be conducted with surgical treatment. A 35-year-old man had a palpable mass on the left side of his occipital scalp without color change, ulceration, or bleeding, which typically are present in malignancy. A magnetic resonance imaging (MRI) scan showed a 3-cm homogenous enhanced mass without adhesion between the scalp and the mass. Unexpectedly, a biopsy revealed the round mass to be DFSP. A wide excision and rotation of the scalp flap were performed. The patient recovered without any complications and received adjuvant radiotherapy at a dose of 60 Gray (Gy) for six weeks. There was no recurrence through six months of follow-up. Here we report this unique case of DFSP with atypical presentation.
Brachiopods and rugose corals in an upper Serpukhovian (Mississippian) biostrome: preliminary results from the Djebel Arhlal (Béchar Basin, Algeria)
Authors: Atif K. F. T. , Aretz M. , Legrand-Blain M. , Bouzid A. , Aimouche M.
Published: June 2024

The Djebel Arhlal is the southernmost outcrop of upper Serpukhovian strata in the Béchar Basin. Here the Djenien member of the Djenien Formation is three-folded and it contains a 10 m-thick coral biostrome in its middle unit formed by Siphonodendron, Diphyphyllum and Lithostrotion. Distances between in situ colonies are in the order of several decimetres and the space between them is filled with bioclastic limestone containing coral rubble. Few brachiopods and solitary corals are found as dwellers within the biostrome, but these groups are much more common in the strata below and above the coral biostrome. This is especially true for the brachiopods, which reach diversities of more than a dozen species in specific horizons. They mainly belong to the orders Productida, Spiriferida and Athyridida. Agitated open-marine platform interior or platform margin settings are the general facies encountered in the Djenien member at the Djebel Arhlal. The field data, including brachiopod coquinas and many fragmented brachiopods and corals, are confirmed by microfacies analysis. However, the coral biostrome records a quieter setting at the interface of middle and outer ramp settings, as seen in the co-existence of in situ coral growth, input of reworked material, deposition of carbonate mud, and sparitic textures. This autoparabiostrome at Djebel Arhlal is compared to other rather thick and of exceptional horizontal extension upper Serpukhovian biostromes (few kilometres).
Biozonation des Foraminifères planctoniques du Crétacé supérieur de Tunisie centro-septentrionale
Authors: Rami A. , Zaghbib-Turki D. , Saadi M.
Published: June 2024

Les séries du Crétacé supérieur étudiées dans les différentes régions de la Tunisie centro-septentrionale ont livré une microfaune particulièrement riche en Foraminifères planctoniques. La richesse et la bonne conservation de ces microfossiles nous ont permis d’établir une biozonation détaillée de l’intervalle Albien p.p. (Vraconien)-Maastrichtien.
L’échelle de zonation établie contient les principaux fossiles marqueurs de Foraminifères planctoniques (15 zones et 5 sous-zones) du Crétacé supérieur adoptés par nos prédécesseurs dans d’autres régions méditerranéennes. Certains fossiles index de cette biozonation sont identifiés à l’échelle planétaire.