bluuebunny/crossref_metadata_2025 huggingface dataset:
The mediating role of inflammation in the association between pregnancy loss history and gestational diabetes mellitus
Authors: Li Qiong , Wang Haixia , Sun Lijun , Wang Peng , Yin Wanjun , Ma Shuangshuang , Tao Ruixue , Ge Jinfang , Zhu Peng
Published: June 2023

Background

To assess the association of pregnancy loss history with an elevated risk of Gestational diabetes mellitus (GDM) and to investigate whether this association was mediated by high-sensitivity C-reactive protein (hs-CRP).

Methods

We prospectively collected venous blood and pregnancy loss history information from 4873 pregnant women at 16–23 weeks of gestation from March 2018 to April 2022. Hs-CRP concentrations were measured from collected blood samples. A 75 g fasting glucose test was performed at 24 to 28 weeks of gestation for the diagnosis of GDM, with data obtained from medical records. Multivariate linear or logistic regression models and mediation analysis were used to examine the relationships between pregnancy loss history, hs-CRP, and GDM.

Results

A multivariable-adjusted logistic regression analysis revealed that compared with pregnant women with no induced abortion history, subjects with 1 and ≥ 2 induced abortions had a higher risk for GDM (RR = 1.47, 95% CI = 1.19–1.81; RR = 1.63, 95% CI = 1.28–2.09). Additionally, the mediation analysis indicated this association was mediated by an increased hs-CRP level with a 20.4% of indirect effect ratio. However, no significant association between a history of miscarriage and the prevalence of GDM was observed.

Conclusions

A history of induced abortion was significantly associated with an increased risk of GDM, and this association occurred in a dose-response effect. Hs-CRP may be accounted for a mediation effect in the pathways linking induced abortion history with GDM.
Association between neck circumference and diabetes mellitus: a systematic review and meta-analysis
Authors: Li Dandan , Zhao Yuxin , Zhang Lifang , You Qiqi , Jiang Qingqing , Yin Xiaoxv , Cao Shiyi
Published: June 2023

Background

Despite that several original researchers have investigated the association between neck circumference (NC) and the risk of diabetes mellitus (DM), their results remain controversial. This review aimed to quantitatively determine the risk of DM in relation to the NC.

Methods

We conducted a literature search of PubMed, Embase, and the Web of Science from these databases’ inception through September 2022 to identify observational studies that examined the association between NC and the risk of DM. A meta-analysis of the random-effects model was applied to combine the results of the enrolled studies.

Results

Sixteen observational studies involving 4,764 patients with DM and 26,159 participants were assessed. The pooled results revealed that NC was significantly associated with the risk of type 2 DM (T2DM) (OR = 2.17; 95% CI: 1.30–3.62) and gestational DM (GDM) (OR = 1.31; 95% CI: 1.17–1.48). Subgroup analysis revealed that after controlling for BMI, the relationship between the NC and T2DM remained statistically significant (OR = 1.94; 95% CI: 1.35–2.79). Moreover, the pooled OR of T2DM was found to be 1.16 (95% CI: 1.07–1.27) for an increment per each centimeter in the NC.

Conclusions

Integrated epidemiological evidence supports the hypothesis that a greater NC is associated with an increased risk of T2DM and GDM.
A new dosing regimen of ropeginterferon alfa-2b is highly effective and tolerable: findings from a phase 2 study in Chinese patients with polycythemia vera
Authors: Jin Jie , Zhang Lei , Qin Albert , Wu Daoxiang , Shao Zonghong , Bai Jie , Chen Suning , Duan Minghui , Zhou Hu , Xu Na , Zhang Sujiang , Zuo Xuelan , Du Xin , Wang Li , Li Pei , Zhang Xuhan , Li Yaning , Zhang Jingjing , Wang Wei , Shen Weihong , Zagrijtschuk Oleh , Urbanski Raymond , Sato Toshiaki , Xiao Zhijian
Published: June 2023

Ropeginterferon alfa-2b represents a new-generation pegylated interferon-based therapy and is administered every 2–4 weeks. It is approved for polycythemia vera (PV) treatment in the United States and Europe with a starting dose of 100 µg (50 µg for patients receiving hydoxyurea) and intra-patient dose titrations up to 500 µg at 50 µg increments, which took approximately 20 or more weeks to reach a plateau dose level. This study aimed to assess ropeginterferon alfa-2b at an alternative dosing regimen with a higher starting dose and quicker intra-patient dose titrations, i.e., the 250–350–500 μg schema, in 49 Chinese patients with PV with resistance or intolerance to hydroxyurea. The primary endpoint of the complete hematologic response rate at treatment weak 24 was 61.2%, which was notably higher than 43.1% at 12 months with the approved dosing schema. The JAK2V617F allele burden decreased from baseline to week 24 (17.8% ± 18.0%), with one patient achieving a complete molecular response. Ropeginterferon alfa-2b was well-tolerated and most adverse events (AEs) were mild or moderate. Common AEs included alanine aminotransferase and aspartate aminotransferase increases mostly at grade 1 or 2 levels. Patients did not present with jaundice or significant bilirubin level increase. No grade 4 or 5 AEs occurred. Seven patients (14.3%) experienced reversible, drug-related grade 3 AEs. No AEs led to treatment discontinuation. Ropeginterferon alfa-2b at the 250–350–500 μg regimen is highly effective and well-tolerated and can help patients achieve greater and rapid complete hematologic and molecular responses.

Clinical Trial Registration: This trial is registered at ClinicalTrials.gov (Identifier: NCT05485948) and in China (China National Medical Products Administration Registration Number: CTR20211664).
The role of 18F-FDG PET/CT in distinguishing benign from malignant portal vein thrombosis
Authors: Abokoura Sameh , Ellaban Heba Said , Aly Rasha Abdelhafiz
Published: June 2023

Background

Diagnosis of tumour thrombosis and differentiating it from benign thrombosis are essential for managing patients, planning treatments, and minimising unneeded anticoagulation therapy. Bland thrombi occur in both cancer and non-cancer patients; tumour thrombi and bland can coexist. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is useful in detecting and diagnosing tumour thrombosis and distinguishing it from benign thrombosis.

Objective

This study’s aim was to assess the value of 18F-FDG PET/CT in distinguishing benign from malignant portal vein thrombosis (PVT) in liver cirrhosis patients.

Methods

A retrospective study was conducted on 38 patients who had PVT that was histopathologically confirmed and performed 18F-FDG PET/CT scans at our institute between January 2021 and April 2022. For all patients, sociodemographic data, visual analysis, semiqualitative analysis (SUVmax value), and associated hepatic pathology were collected.

Results

The SUVmax values were significantly higher in the tumour thrombosis group (6.26 ± 1.94), compared to the bland thrombosis group (1.79 ± 0.69), (P < 0.001). The ROC curve of semiqualitative analysis (SUVmax) revealed a sensitivity of 96.3% and a specificity of 36.4%, at area under curve of 0.827 with SUVmax > 3.5 as the pathological cut-off value to distinguish tumour from bland thrombi.

Conclusions

By using semiqualitative analysis, 18F-FDG PET/CT is a valuable new technique in differentiating between neoplastic and bland PV thrombi, with optimal cut-off SUVmax value > 3.5 as a criterion.
GC-MS analysis of honeybee products derived from medicinal plants
Authors: Montaser Maha , Sayed Ahmed M. , Bishr Mokhtar M. , Zidan Ehab W. , Zaki Mohamed A. , Hassan Hossam M. , Mohammed Rabab , Hifnawy Mohamed S.
Published: June 2023

Background

Honeybees provide a wealth of valuable natural products containing health-promoting bioactive compounds, including honey, bee bread, bee venom, bee pollen, propolis, and royal jelly. In the present study, we investigated the chemical composition of four honeybee products (bees, honey, royal jelly, and bee bread) derived from three medicinal plants (marjoram, trifolium, and citrus) using headspace GC-MS.

Results

GC-MS analysis coupled with the headspace method resulted in identification of 24 volatile compounds in marjoram honey, 14 volatile compounds in trifolium honey, and 25 volatile compounds in citrus honey, e.g., some of these compounds appeared in all three types of honey aroma, which are 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 2-furancarboxaldehyde, 5-(hydroxymethyl) and other unique compounds specific for each type where 23 compounds were from marjoram bees, 38 compounds from trifolium bees, and about 37 compounds were identified in citrus bees where 2,4-decadienal, (E, E) and methyl N-methyl anthranilate were common in all. Furthermore, the volatile compounds of all three types of royal jelly aroma were acetic acid, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 8-nonen-2-one and furfural where one compound appeared in both marjoram and trifolium royal jelly that is 2-furancarboxaldehyde,5-(Hydroxymethyl) and the volatile compounds in marjoram and citrus are 2,3-butanediol and 5-methylfurfural also only one volatile compound appear in both trifolium and citrus royal jelly that is furfur alcohol, Finally, 3 compounds from marjoram bee bread, 30 volatile compounds from trifolium bee bread, and 3 volatile compounds in citrus bee bread were identified.

Conclusions

A detailed metabolomic analysis of the four honey product groups revealed an intriguing chemical diversity, with each sample exhibiting its own chemical fingerprint.
Clinical index to quantify the 1-year risk for common postpartum mental disorders at the time of delivery (PMH CAREPLAN): development and internal validation
Authors: Vigod Simone N. , Urbach Natalie , Calzavara Andrew , Dennis Cindy-Lee , Gruneir Andrea , Thombs Brett D. , Walker Mark , Brown Hilary K.
Published: June 2023

Background

Common postpartum mental health (PMH) disorders such as depression and anxiety are preventable, but determining individual-level risk is difficult.

Aims

To create and internally validate a clinical risk index for common PMH disorders.

Method

Using population-based health administrative data in Ontario, Canada, comprising sociodemographic, clinical and health service variables easily collectible from hospital birth records, we developed and internally validated a predictive model for common PMH disorders and converted the final model into a risk index. We developed the model in 75% of the cohort (n = 152 362), validating it in the remaining 25% (n = 75 772).

Results

The 1-year prevalence of common PMH disorders was 6.0%. Independently associated variables (forming the mnemonic PMH CAREPLAN) that made up the risk index were: (P) prenatal care provider; (M) mental health diagnosis history and medications during pregnancy; (H) psychiatric hospital admissions or emergency department visits; (C) conception type and complications; (A) apprehension of newborn by child services (newborn taken into care); (R) region of maternal origin; (E) extremes of gestational age at birth; (P) primary maternal language; (L) lactation intention; (A) maternal age; (N) number of prenatal visits. In the index (scored 0–39), 1-year common PMH disorder risk ranged from 1.5 to 40.5%. Discrimination (C-statistic) was 0.69 in development and validation samples; the 95% confidence interval of expected risk encompassed observed risk for all scores in development and validation samples, indicating adequate risk index calibration.

Conclusions

Individual-level risk of developing a common postpartum mental health disorder can be estimated with data feasibly collectable from birth records. Next steps are external validation and evaluation of various cut-off scores for their utility in guiding postpartum individuals to interventions that reduce their risk of illness.
Survival After Implementation of a Decision Support Tool to Facilitate Evidence-Based Cancer Treatment
Authors: Ojha Rohit P. , Lu Yan , Narra Kalyani , Meadows Rachel J. , Gehr Aaron W. , Mantilla Emmanuel , Ghabach Bassam
Published: June 2023

PURPOSE

Decision support tools (DSTs) to facilitate evidence-based cancer treatment are increasingly common in care delivery organizations. Implementation of these tools may improve process outcomes, but little is known about effects on patient outcomes such as survival. We aimed to evaluate the effect of implementing a DST for cancer treatment on overall survival (OS) among patients with breast, colorectal, and lung cancer.

METHODS

We used institutional cancer registry data to identify adults treated for first primary breast, colorectal, or lung cancer between December 2013 and December 2017. Our intervention of interest was implementation of a commercial DST for cancer treatment, and outcome of interest was OS. We emulated a single-arm trial with historical comparison and used a flexible parametric model to estimate standardized 3-year restricted mean survival time (RMST) difference and mortality risk ratio (RR) with 95% confidence limits (CLs).

RESULTS

Our study population comprised 1,059 patients with cancer (323 breast, 318 colorectal, and 418 lung). Depending on cancer type, median age was 55-60 years, 45%-67% were racial/ethnic minorities, and 49%-69% were uninsured. DST implementation had little effect on survival at 3 years. The largest effect was observed among patients with lung cancer (RMST difference, 1.7 months; 95% CL, –0.26 to 3.7; mortality RR, 0.95; 95% CL, 0.88 to 1.0). Adherence with tool-based treatment recommendations was >70% before and >90% across cancers.

CONCLUSION

Our results suggest that implementation of a DST for cancer treatment has nominal effect on OS, which may be partially attributable to high adherence with evidence-based treatment recommendations before tool implementation in our setting. Our results raise awareness that improved process outcomes may not translate to improved patient outcomes in some care delivery settings.
Ensuring Ethical Postprogression Therapy for Patients in Randomized Trial Control Arms
Authors: Cliff Edward R. Scheffer , Kesselheim Aaron S. , Feldman William B.
Published: June 2023

@Eddie_Cliff et al explore the scientific & ethical reasons why patients randomized to the control arm of trials should 'crossover' to receive the investigational therapy if their disease progresses
Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
Authors: Buttigieg Marco M. , Rauh Michael J.
Published: June 2023

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients.
Obstetric and Gynecologic Disorders and the Nervous System
Authors: Marulanda Erika , Tornes Leticia
Published: June 2023

OBJECTIVE

This article discusses obstetric and gynecologic associations with common neurologic disorders.

LATEST DEVELOPMENTS

Neurologic complications of obstetric and gynecologic disorders can arise throughout the lifespan. Caution should be exercised when prescribing fingolimod and natalizumab to patients with multiple sclerosis who are of childbearing potential because of the risk of disease rebound when they are discontinued. OnabotulinumtoxinA is considered safe in pregnancy and lactation based on long-term observational data. Hypertensive disorders of pregnancy are associated with higher subsequent cerebrovascular risk, likely via multiple mechanisms.

ESSENTIAL POINTS

Neurologic disorders may present in a variety of obstetric and gynecologic contexts, with meaningful implications for recognition and treatment. These interactions must be considered when treating women with neurologic conditions.
Hematologic Disorders and the Nervous System
Authors: Mauermann Michelle L. , Southerland Andrew M.
Published: June 2023

OBJECTIVE

This article discusses the epidemiology, diagnosis, treatment, and prevention of neurologic complications of red blood cell, platelet, and plasma cell disorders.

LATEST DEVELOPMENTS

Cerebrovascular complications can occur in patients with blood cell and platelet disorders. Treatment strategies to prevent stroke are available for patients with sickle cell disease, polycythemia vera, and essential thrombocythemia. A diagnosis of thrombotic thrombocytopenic purpura should be considered in patients with neurologic symptoms, hemolytic anemia, thrombocytopenia, mild renal insufficiency, and fever. Plasma cell disorders can be associated with peripheral neuropathy, and classification of the monoclonal protein type and neuropathy aid in diagnosis. Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome can present with arterial and venous neurologic events.

ESSENTIAL POINTS

This article discusses the neurologic complications of blood cell disorders and the most recent advances in prevention and treatment.
Viral evasion of the interferon response at a glance
Authors: Zhu Junji , Chiang Cindy , Gack Michaela U.
Published: June 2023

Re-emerging and new viral pathogens have caused significant morbidity and mortality around the world, as evidenced by the recent monkeypox, Ebola and Zika virus outbreaks and the ongoing COVID-19 pandemic. Successful viral infection relies on tactical viral strategies to derail or antagonize host innate immune defenses, in particular the production of type I interferons (IFNs) by infected cells. Viruses can thwart intracellular sensing systems that elicit IFN gene expression (that is, RIG-I-like receptors and the cGAS–STING axis) or obstruct signaling elicited by IFNs. In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge about the major mechanisms employed by viruses to inhibit the activity of intracellular pattern-recognition receptors and their downstream signaling cascades leading to IFN-based antiviral host defenses. Advancing our understanding of viral immune evasion might spur unprecedented opportunities to develop new antiviral compounds or vaccines to prevent viral infectious diseases.
RELACIÓN ENTRE PERCEPCIONES DE LA ENSEÑANZA, SEXO Y ACTITUDES HACÍA LAS MATEMÁTICAS DE ESTUDIANTES
Authors: Radovic S. Darinka , Pampaka María
Published: June 2023

Este artículo explora la relación entre las percepciones de estudiantes sobre el tipo de enseñanza que experimentan en matemáticas [más o menos centrada en el estudiantado] y sus emociones, autoconcepto y disposición hacia las matemáticas. También considera la pregunta de si existen diferencias en esta relación con respecto al sexo del estudiantado. Utiliza datos de casi 300 estudiantes de Chile de 7 año, agrupados en 8 aulas de clases. El análisis correlacional sugiere la existencia de una asociación positiva y significativa entre cuán centrada en los estudiantes es percibida la enseñanza y actitudes más positivas del estudiantado hacia las matemáticas. Sin embargo, este efecto es independiente del sexo, sugiriendo que la enseñanza centrada en estudiantes no necesariamente ofrecen una ventaja para las niñas, sino que son positivas tanto para alumnas como para alumnos.
Vicarious Learning Without Knowledge Differentials
Authors: Park Sanghyun , Puranam Phanish
Published: June 2023

The benefits of vicarious learning are usually conceptualized in terms of a mechanism for learners to utilize the superior knowledge of others. Building on the fact that vicarious learning typically co-occurs and interacts with individual learning-by-doing, we propose an alternative mechanism—one in which vicarious learning is useful because it corrects for certain well-known limitations of individual learning-by-doing. Using computational agent-based models, we show that, under this mechanism, vicarious learning can be beneficial, even without any ex ante differential knowledge to exploit. Our analysis contributes to a deeper understanding of the microfoundations of vicarious learning, which is a vital component of organizational learning. We draw implications for empirical analysis and managerial practice.

This paper was accepted by Lamar Pierce, organizations.

Funding: Financial support from The Desmarais Fund at INSEAD is gratefully acknowledged.

Supplemental Material: The data file and online appendix are available at https://doi.org/10.1287/mnsc.2023.4842 .
Are patients with HHV-8 associated Castleman disease successfully treated with rituximab at risk of subsequently developing HHV-8 negative (idiopathic) Castleman disease? iMCD after HHV-8-associated MCD
Authors: Ha Gavin , Kwong Kelsey , Tanaka Bryce , Nishimura Yoshito , Chong Christina
Published: June 2023

Introduction: Multicentric Castleman disease (MCD) is a lymphoproliferative disorder characterized by lymph node histopathology and systemic symptoms. To our knowledge, there are no descriptions in the literature of long-term outcomes of human herpesvirus-8 (HHV-8)-associated MCD. Case Description: We report a case of a 70-year-old male living with human immunodeficiency virus and a history of human herpesvirus-8 (HHV-8)-associated MCD. The patient reported having had low-grade fever for two weeks. Extensive workup revealed systemic lymphadenopathy without evidence of autoimmune disease or malignancy. Lymph node biopsy was consistent with HHV-8-negative idiopathic MCD (iMCD). The patient was subsequently scheduled for anti-interleukin-6 therapy. Discussion: The present case is the first report of probable development of iMCD after long-term follow-up for HHV-8-associated MCD. The case illustrates the possible long-term consequences of MCD, suggesting the necessity of further research on the pathogenesis of CD. Conclusion: Given the uncertainty in the long-term outcomes of HHV-8-associated MCD, periodic surveillance of patients with a history of HHV-8-associated MCD is warranted. Prospective nationwide cohort studies comparing characteristics of HHV-8-associated MCD and iMCD would bring further insights.
Primary splenic diffuse large B-cell lymphoma: a case report
Authors: Maia Neves Nuno , Lopes Ana Pestana , Carvalho Coelho Susana , Raimundo Anabela , Mafra Maria Manuela , Bayão Horta Alexandra
Published: June 2023

Primary splenic lymphoma (PSL) is a rare disease and an improbable cause of splenomegaly or splenic nodules. On the contrary, splenic secondary involvement as part of an advanced lymphoproliferative disorder is more common. The authors present the case of a 49-year-old woman with a primary splenic diffuse large B-cell lymphoma (PS-DLBCL), in which the absence of other organs’ involvement determined an ultrasound-guided biopsy of the spleen to achieve a definitive diagnosis. With this case the authors intend to emphasise the extensive differential diagnosis of splenomegaly, splenic nodules or infiltrates, the usefulness of splenic biopsy in establishing the diagnosis and recall a rare disease, with non-specific presenting symptoms, in which the diagnostic workup is challenging.
Post-death burial and funeral practices in rural Alberta
Authors: Grainger Brooklyn , Wilson Donna M , Rainsford Suzanne
Published: June 2023

Background:

Burial and funeral practices are important customary mortuary rituals, especially in rural areas as people are likely to have different values and interests than people who live in larger cities. However, little is known about rural post-death practices in Canada.

Aims:

This review gathered information on funeral and burial practices in rural Alberta, a western Canadian province with a diverse rural population.

Methods:

A literature review of community print sources, including obituaries and funeral home websites, was conducted for select representative rural communities.

Findings:

This review found that cremations outnumber burials, and mortuary ceremonies more commonly occur in non-religious settings. Furthermore, personalised post-death rituals were identified as highly significant to rural people as they allow the dead to remain connected to their rural land, family and community.

Conclusion:

It is important to understand rural mortuary rituals to help prepare dying rural people and their families.
Paediatric end-of-life care at home
Authors: Larsen Signe Hoff Kobborg , Bording Inger , Bjergegaard Margit , Buchreitz Jakob , Mouritzen Bente Toth , Brix Lotte , Jespersen Bodil Abild , Neergaard Mette Asbjoern
Published: June 2023

Background:

A terminally ill child should have the possibility to be at home with their family during the end of life. Provision of care from primary care nurses (PCNs) is crucial, but no model exists on how specialised paediatric palliative care teams (SPPCTs) support the PCNs to perform this task.

Aim:

To investigate how PCNs evaluated a shared care model between a SPPCT and PCNs in paediatric end-of-life care.

Method:

A 23-item questionnaire was distributed to PCNs involved in care of 14 terminally ill children in November 2019 and January 2020. Descriptive statistics were used.

Findings:

A total of 20 questionnaires were returned from nurses who agreed/completely agreed that an introductory meeting made them better prepared (78.9%) to deal with the death of a child in their care, cooperating with family members (70.6%) and dealing with own emotions (73.7%). A total of 69.2% felt the meeting helped coping with parents' pressure and 88.9% stated that the trajectory changed how they saw themselves involved in future paediatric palliative care.

Conclusion:

The shared care model was evaluated positively. Clear agreements and specialist support were prerequisites for good trajectories at the end of life. Further research is needed to investigate if the shared care model optimises palliative care and security in relation to child and family.
Academic Chairs’ Leaderships Styles and Teachers’ Job Satisfaction in Higher Education Institutions in UAE
Authors: Mahmoud Elsayed , Belbase Shashidhar , Alsheikh Negmeldin
Published: June 2023

This study aims to identify the dominant leadership styles of chairs from the perspective of faculty members in different college departments in higher education in the UAE. Furthermore, the study aims to identify the teachers' perceptions of leadership styles that affect their job satisfaction. The study used quantitative means with faculty members in different higher educational settings in the UAE. The survey used a five-point Likert scale. The leadership styles have values (completely agree =5, agree = 4, neutral =3, disagree=2, completely disagree=1). The job satisfaction questions have values (completely satisfied =5, satisfied = 4, fairly satisfied =3, dissatisfied =2, completely dissatisfied=1). The chosen subjects were faculty members from different colleges. Those subjects are 135 university teachers who are divided into four age groups. The data revealed no dominant leadership styles in the colleagues from faculty members' perspectives; however, the statistics lean towards the laissez-faire leadership style. It also reveals correlations between the three leadership styles and job satisfaction. The democratic leadership style has the greatest impact and most significant environment and incentives among the three independent variables.
The Mediating Effect of Work-Life Balance in the Relationship Between Job Stress and Career Satisfaction
Authors: Çobanoğlu Fatma , Yıldırım Özen , Şarkaya Sevda Seven , Sertel Gülsüm
Published: June 2023

This study is aimed to find out the mediating role of work-life balance in the relationship between job stress and career satisfaction. The responses of high school teachers to career satisfaction, work life balance and work stress scales were utilized in the study. The data was analyzed using SPSS 26, Lisrel 8.80 and Jamovi 2.3. According to the results, one of the important determinants of teachers' career satisfaction is the work-life balance; there is a negative relationship between job stress and career satisfaction, and as the job stress increases, the work-life balance decreases. Finally, in the model, it was found that teachers’ job stress has a direct effect on career satisfaction, but also has an indirect effect through work-life balance. Based on all these results, educational organizations need to reorganize the work environment and conditions that will provide career satisfaction and work-life balance to their employees. However, while making these arrangements, it is of great importance to eliminate or even remove the factors that create job stress.
The Antimicrobial Properties of Malaysian Propolis as Intracanal Medicament in Endodontics
Authors: Rosli N. , Elliaziz N.A. Che , Al-Bayaty F.H. , Ismail I.H.
Published: June 2023

Numerous studies have shown that propolis, from the sting and stingless bees, possessed antimicrobial, antifungal, antidiabetic, antitumoral and antioxidant properties. Propolis produced by stingless bees, Heterotrigona itama, also possessed these properties but in varying intensity. Exploiting this natural product with antimicrobial properties against Enterococcus faecalis (EF), would be advantageous in endodontics. Particularly where the current synthetic medicament, calcium hydroxide (Ca(OH)2), failed to remove these bacteria, predominantly found in failed root canal-treated (RCT) teeth. The aims of this study are to determine the antimicrobial properties of Malaysian propolis (MP) against Enterococcus faecalis and to compare the antibacterial effect of MP with Ca(OH)2 as an intra-canal medicament. Raw propolis was purchased from Humaira Honey Sdn Bhd, Lenggong, Perak and the ethanolic extraction method was carried out until lyophilization. Antimicrobial susceptibility testing (AST) was done on five samples, namely, MP, Ca(OH)2, 2% chlorhexidine (CHX), 70% ethanol, and sterile normal saline (SDW), where CHX, 70% ethanol and SDW as controls. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) methods were carried out. The MIC and MBC for MP and CHX were done using the micro-dilution method on 96-well, while Ca(OH)2 were performed using the serial macro-dilution method. The results were analysed by Kruskal Wallis test with Mann-Whitney posthoc test and repeated-measures ANOVA with Bonferroni post hoc test (p <0.05). The mean MIC from three trials that were carried out on the samples was CHX (<0.008%) < MP (0.03%) < Ca(OH)2 (0.62%). While the MBC values for three trials were found to be CHX (0.011%) < MP (0.07%) < Ca(OH)2 (1.25%). In conclusion, MP was shown to be antibacterial and effective against Enterococcus faecalis and is more effective when compared to Ca(OH)2, which is commonly used as an intra-canal medicament. Further research is needed to test MP’s clinical efficacy.
Combinatorial barcoding of cells with Laser Particles
Authors: Martino Nicola , Yan Hao , Kim Kwon-Hyeon , Dannenberg Paul H. , Wu Yue , Abbot Geoffrey , Zhu Han , Kwok Sheldon J.J. , Yun Seok-Hyun
Published: June 2023

Laser Particles are a novel class of microparticles with discrete emission lines that function as optically readable barcodes. Here, we introduce their use as intracellular tags to uniquely identify individual cells.
Development of Multifocal Optical Coherence Tomography and Ocular Phantom for Wide Field Murine Eye Imaging
Authors: Brais-Brunet Simon , Maltais-Tariant Raphaël , Boudoux Caroline , Dehaes Mathieu
Published: June 2023

Retinal and vitreous imaging of murine models with optical coherence tomography allows longitudinal investigations of ocular diseases. Here, we present a multifocal lens imaging system calibrated with an ocular phantom mimicking the mouse eye.
Investigations on Performance Parameters of Phakic Intraocular Lens using a Wavefront Sensor
Authors: Prakash Avijit , Gupta Arpit , Burada Dali Ramu , Khan Gufran S
Published: June 2023

The paper presents a slope based wavefront sensor for testing of phakic Intraocular lenses (pIOLs). A Shack-Hartmann wavefront sensor is used to measure the performance parameters in order to optimise the pIOLs. Both the simulation and experimental results have been presented.
Reconstructing polarimetric information from existing intravascular optical frequency domain imaging data
Authors: Jones Georgia , Otsuka Kenichiro , Bouma Brett E. , Villiger Martin
Published: June 2023

Using the inherent properties of existing clinical intravascular OFDI systems, we present a robust signal processing software which resolves the polarization properties of coronary plaques and apply this method to existing patient datasets.
A Comparative Study of Image Reconstruction Methods in Full Field Optical Coherence Tomography (FF-OCT) for Biological Tissues
Authors: S Dushyanth , Chakraborty Sandeep , Kuo Wen-Chuan , Anna Tulsi
Published: June 2023

A systematic comparative analysis of image reconstruction algorithms has been performed for full-field optical coherence tomography. Results suggest that derivative based method can overcome significantly the residual fringes compared to other algorithms for biological applications.
Real-space Structured Illumination Microscopy Reconstruction by Iterative Optimization
Authors: Shepherd Douglas P. , Brown Peter T.
Published: June 2023

We develop a real-space reconstruction approach for structured illumination microscopy using physics inspired machine learning and automatic differentiation. By optimizing pattern parameters during reconstruction, our approach suppresses common artifacts.
Speckle Contrast Reduction through the use of a Modally-Specific Photonic Lantern in Few-Modes Optical Coherence Tomography
Authors: Maltais-Tariant Raphaël , Brais-Brunet Simon , Dehaes Mathieu , Boudoux Caroline
Published: June 2023

We demonstrate how a modally-specific photonic lantern can be used in optical coherence tomography to both reduce speckle contrast and increase signal-to-noise ratio.
Real time diagnosis and mapping of ablative margins for prostate cancer using rapid on-site microscopy
Authors: Behr Madeline , Halat Shams , Sholl Andrew , Krane L. Spencer , Brown J. Quincy
Published: June 2023

Structured illumination microscopy can add valuable on-site feedback during diagnostic prostate biopsy procedures to triage to potential localized intervention and guide mapping of ablative margins.
Age-Related Changes in Tissue Structure of the Heart Left Ventricle Assessed with Multiphoton Microscopy
Authors: Bueno Juan M. , Martínez-Ojeda Rosa M. , Asensio M. Carmen , García-Mendívil Laura , Pérez-Zabalza María , Ordovás Laura , Pueyo Esther
Published: June 2023

Multiphoton microscopy has been used to explore age-related changes in the tissue arrangement of the left ventricle in a porcine model. Images reveal significant differences.
Optical Coherence Tomography Enabled Classification of the Human Venoatrial Junction
Authors: Joasil Arielle S. , Therien Aidan M. , Hendon Christine P.
Published: June 2023

The venoatrial junction is an important substrate of atrial fibrillation. We showcase that OCT sub-images of the venoatrial junction can be classified as left atrium or pulmonary vein using a deep CNN with high accuracy.
Clinical prototype of multi-spot air-puff OCT for assessment of corneal biomechanical asymmetry
Authors: Karnowski Karol , Milkiewicz Jadwiga , Pachacz Angela , Curatolo Andrea , Cetinkaya Onur , Pietruch Rafal , Consejo Alejandra , Bartuzel Maciej , Eliasy Ashkan , Abass Ahmed , Elsheikh Ahmed , Marcos Susana , Wojtkowski Maciej
Published: June 2023

The ability to perform multi-meridian, simultaneous measurements of air-induced corneal deformation is expected to highly improve the accuracy of assessing corneal biomechanics. We propose a simplified method targeting 3-D deformation measurements that could be introduced to any swept-source OCT system. We utilize a spatial-depth-encoded multiplexing technique to provide a 9-spot measurement of the deformation. The method is promising for the assessment of corneal deformation asymmetries in the detection and diagnosis of corneal pathologies such as keratoconus. We present in detail the system and key requirements to provide simultaneous 9-spot deformation measurement. Finally, results on porcine eyes ex vivo and human eye in vivo are presented.
Spatio-temporal optical coherence tomography (STOC-T) for high-resolution imaging of the human and mouse retina in vivo
Authors: Borycki Dawid , Węgrzyn Piotr , Egidijus Auksorius , Kulesza Wiktor , Tomczewski Sławomir , Curatolo Andrea , Wojtkowski Maciej
Published: June 2023

We developed and applied spatio-temporal optical coherence tomography (STOC-T), which supported by computational aberration correction enables high resolution imaging of the human and mouse retina in vivo.
Spatio-Temporal Optical Coherence Tomography with optimized light source for in vivo imaging of chorioretinal complex
Authors: Auksorius Egidijus , Adomavičius Karolis , Borycki Dawid , Węgrzyn Piotr , Tomczewski Slawomir , Liżewski Kamil , Žičkienė Ieva , Wojtkowski Maciej
Published: June 2023

We present an optical imaging system, termed STOC-T, for in vivo imaging of chorioretinal complex that uses an optimized multimode fiber for crosstalk noise reduction in OCT images.
Localization-based spot decoding for accurate multiplexed RNA-FISH at scale
Authors: Coullomb Alexis , Brown Peter , Shepherd Douglas
Published: June 2023

A new spot decoding method allows to infer at scale and more accurately mRNA species from 3D spots localized with a physics-based approach in big datasets of barcoded RNA-FISH experiments.
Surface-enhanced Raman spectroscopy (SERS) for the detection of Rhodamine 6G and Crystal Violet
Authors: Kaur Navneet , Varsha Varsha , Das Gautam
Published: June 2023

A SERS substrate was manufactured using gold nanorods on the tapered optical fiber, which assisted in detecting Rhodamine 6G (R6G) and Crystal Violet (CV) at low concentrations. The distribution of gold nanorods produced a rough surface.
Cherenkov Light Emission in Intensity Modulated Radiation Therapy of the Larynx
Authors: Dubal Jigar , Arce Pedro , Florescu Lucia
Published: June 2023

We perform numerical experiments based on Monte Carlo simulations and clinical data to investigate Cherenkov light emission in intensity modulated radiation therapy of laryngeal cancer and demonstrate that Cherenkov light-based tumour probing could be feasible.
The Use of Optical Coherence Tomography to Evaluate the Effects of Glyphosate on Aquatic Organisms
Authors: Meemon Panomsak , Thanomsit Chutima
Published: June 2023

We have investigated the use of optical coherence tomography (OCT) to assess morphological changes or tissue damage in glyphosate-exposed freshwater organisms, such as fish, prawns, and shellfish, as compared to non-exposed samples.
Classification of Microbial Samples Using Two-Color Line-of-Sight Fluorescence Imaging
Authors: Herzog Joshua M. , Sick Volker
Published: June 2023

Rapid, low-cost diagnosis of infections is challenging and requires innovation. Two-color fluorescence imaging is proposed to distinguish between microbial species. Microbial smear images show the technique is promising for classifying species in vitro.
Speckle and Shadow Artifacts Reduction in Scattering-Based Light Sheet Microscopy
Authors: Zhao J. , Liang B. , Dobo E. , Khan M. J. , Yang E. , Kang D.
Published: June 2023

Scattering-based light sheet microscopy (sLSM) using a laser had challenges with speckle noise and shadow artifacts. We developed an LED-based sLSM setup that significantly reduces speckle noise and shadow artifacts.
Quantifying Age-Related Changes in Skin Microstructure and Function Using In Vivo Multiphoton Microscopy
Authors: Rodriguez Marcos R. , Woessner Alan E. , Edison Ragan , Quinn Kyle P.
Published: June 2023

Through label-free multiphoton microscopy, aged skin exhibited changes in autofluorescence and second harmonic generation indicating reduced glucose catabolism and a more fragmented collagen fiber network relative to young skin.
Deep Learning Methods for Sensorless Adaptive Optics
Authors: Xu Guozheng , Garnreiter Isabelle , Smart Thomas J. , Chambers Michael G. , Durech Eduard , Ng Ringo , Sun Jennifer , Sarunic Marinko V.
Published: June 2023

We present our progress on image-guided (wavefront sensor-less) adaptive optics using Deep Learning Methods to optimize the image quality using high numerical aperture OCT and confocal microscopy with a custom developed instrument.
Fluorescence-based multiplexed point-of-care sensor using deep learning
Authors: Goncharov Artem , Joung Hyou-Arm , Ghosh Rajesh , Han Gyeo-Re , Ballard Zachary S. , Maloney Quinn , Bell Alexandra , Aung Chew Tin Zar , Garner Omai B. , Di Carlo Dino , Ozcan Aydogan
Published: June 2023

We present a multiplexed paper-based point-of-care sensor processed by a hand-held fluorescence reader and neural networks that quantify three cardiovascular disease biomarkers from human serum samples, achieving a limit-of-detection of ≤0.52 ng/mL for each biomarker.
The design of Optical Coherence Tomography Probe in Dermatology
Authors: Le Nhan M. , Lu Jie , Xing Zhiying , Shi Yaping , Sathyakumar Athira B. , Wang Ruikang
Published: June 2023

We summarized our recent developments in optical coherence tomography and its utility in clinical settings as a diagnostic and monitoring tool, and in cosmetics as an assessment tool.
Deep Brain Polarization Sensitive Optical Coherence Tomography: Depth Resolved Retardance and Optic Axis Measurement
Authors: Masoumi Shadi , Jones Georgia , Lee Jaeyul , Quémener Mireille , Hariri Lida P. , Parent Martin , Cote Daniel C. , Villiger Martin
Published: June 2023

We present improved reconstruction of depth-resolved optic axis orientation in catheter-based polarization-sensitive optical coherence tomography, by using the intrinsic retardance of the catheter-sheath as reference, and image white matter fiber bundles in sheep brain.
Towards point-of-care diagnostics and monitoring of hyper-tensive episodes (A Monte Carlo approach)
Authors: Main Mark , Kallepalli Akhil
Published: June 2023

We present an assessment of photon transport through healthy and hypertensive tissue models using Monte Carlo methods. The tissue models (including skin layers and blood vessels) are assessed under red wavelength illumination in TracePro.
Parallel interferometric near-infrared spectroscopy (rcNIRS) monitors the blood flow and absorption of the human brain in vivo
Authors: Borycki Dawid , Samaei Saeed , Nowacka Klaudia
Published: June 2023

We developed and applied parallel interferometric near-infrared spectroscopy (πNIRS) for rapid cerebral blood flow and absorption monitoring. By operating ~100-500x faster than competing optical techniques, we can monitor prefrontal cortex activation in humans in vivo.
Augmented optical neural implants using plasmonic nanomodulators integrated on multimode fibers
Authors: Pisano Filippo , Collard Liam , Kashif Muhammad Fayyaz , Balena Antonio , Pisanello Marco , Zheng Di , De Angelis Francesco , Grande Marco , Ciracì Cristian , De Vittorio Massimo , Pisanello Ferruccio
Published: June 2023

We present a strategy to enhance the performances of optical neural implants using the interaction of light guided in multimode fibers with angle- and wavelength-dependent resonances supported by integrated plasmonic metasurfaces.
Enhanced Uptake and Retention of Graphene Quantum Dots in HeLa Cell Nuclei.
Authors: Gorav Gorav , Khedekar Vrushali , Varier Geetha K. , Nandakumar P.
Published: June 2023

The nuclear pore complex (NPC) is an intricate protein structure located on the nuclear envelope that functions as the sole gateway for nuclear cytoplasm transport. Our experimental studies show the dual uptake rates of GQDs in HeLa nuclei indicate two phenomena occurring simultaneously. Export studies confirm bidirectionality and retention.
Spherical Aberration and Scattering Compensation in Microscopy Images through a Blind Deconvolution Method
Authors: Bueno Juan M. , Ávila Francisco J.
Published: June 2023

A deconvolution method based on both spherical aberration and scattering compensation has been proposed to enhance the quality of images acquired with different types of microscopes.
Characterization of camera performance to correct speckle contrast estimates
Authors: Kim Byungchan , Cheng Tom Y. , Zilpelwar Sharvari , Boas David A. , Cheng Xiaojun
Published: June 2023

We have developed a camera characterization protocol to estimate the camera parameters needed for estimation of fundamental speckle contrast in photon-starved speckle contrast optical spectroscopy (SCOS) systems.
Third Harmonic Generation Textural Analysis of Alzheimer’s Disease Brain Tissues
Authors: Bhuvanesh Swathy , Anna Tulsi , Sun Chi-Kuang , Chakraborty Sandeep
Published: June 2023

Third harmonic generation microscopy textural analysis is used to differentiate Alzheimer’s disease (AD) stages between 8- and 15-months old AD mice models. Obtained Haralick’s textural features can differentiate these stages with high sensitivity and specificity.
Correlated Structural and Functional Deficits in a Mouse Model of Demyelination
Authors: Das Aniruddha , Borovicka Julie , Icardi Jacob , Agochiya Priyanka , Singh Shriya , Dana Hod
Published: June 2023

Concurrent two-photon and third-harmonic generation microscopy recordings from the hippocampus of mice fed with cuprizone to induced demyelination showed a correlation between the severity of myelin loss and reduced neuronal firing in the same mice.
Extensive Mie scattering analysis for biomedical application using PyMieSim.
Authors: de Sivry-Houle Martin Poinsinet , Godbout Nicolas , Boudoux Caroline
Published: June 2023

Introducing PyMieSim, a Python simulation package for Mie scattering analysis from light emission to detection. The library is first employed to study the effect of structured field collection in coherent detection schemes, demonstrating an emerging property that allows for previously unexploited contrast mechanism. We, then, showcase the rapid library computing speed towards optimizing the design of a flow-cytometry system.
Design And Simulation of Lithium Niobate Thin Film Ridge Waveguide for Integrated Optics Applications
Authors: K. Dismas Choge , Waswa David W.
Published: June 2023

We propose a TFLN ridge waveguide with a Si3N4 strip for photonic integrated circuits applications. The dispersion is found to be -0.1 ps/m/nm at 1550 nm which is 6 times higher than single-mode fiber dispersion.
Flicker optoretinography (f-ORG) with chirped frequency stimulus for retinal tissue characterisation
Authors: Wojtkowski Maciej , Tomczewski Slawomir , Węgrzyn Piotr , Curatolo Andrea
Published: June 2023

We used the flicker ORG method with a variable frequency stimulus to measure the frequency characteristics of photoreceptor activity. Data are collected using a Spatio-Temporal Optical Coherence Tomographic (STOC-T) system. We use a white-light LED for stimulation, which is driven by a linear chirped signal (5 Hz to 45 Hz). This approach allows much faster response measurements across the available spectrum than performing data acquisition at individual frequencies.
Measuring brain function during motor imitation with high-density diffuse optical tomography (HD-DOT)
Authors: George Tessa G. , Yang Dalin , King Kelsey T. , McMorrow Sophia R. , Sobolewski Chloe M. , Tunçgenç Bahar , Nebel Mary Beth , Marrus Natasha M. , Mostofsky Stewart H. , Eggebrecht Adam T.
Published: June 2023

We utilized HD-DOT to image fifty adults as they observed and imitated sequences of upper extremity movements. We show HD-DOT is resilient to movement and successfully maps spatially distributed brain function during gross motor movements.
In vivo stiffness mapping of the human cornea using high-frequency optical coherence elastography
Authors: Feng Xu , Li Guo-Yang , Ramier Antoine , Yun Seok-Hyun
Published: June 2023

Measuring the spatial variation of the cornea has clinical significance for diagnosing corneal ectasia disease and evaluating refractive surgery outcomes. We present spatially-resolved stiffness mapping of the human cornea in vivo using optical coherence elastography.