bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiview deep learning based on tensor decomposition and its application in fault detection of overhead contact systems
Authors: Zhang Xuewu , Gong Yansheng , Qiao Chen , Jing Wenfeng
Published: February 2021

This article mainly focuses on the most common types of high-speed railways malfunctions in overhead contact systems, namely, unstressed droppers, foreign-body invasions, and pole number-plate malfunctions, to establish a deep-network detection model. By fusing the feature maps of the shallow and deep layers in the pretraining network, global and local features of the malfunction area are combined to enhance the network's ability of identifying small objects. Further, in order to share the fully connected layers of the pretraining network and reduce the complexity of the model, Tucker tensor decomposition is used to extract features from the fused-feature map. The operation greatly reduces training time. Through the detection of images collected on the Lanxin railway line, experiments result show that the proposed multiview Faster R-CNN based on tensor decomposition had lower miss probability and higher detection accuracy for the three types faults. Compared with object-detection methods YOLOv3, SSD, and the original Faster R-CNN, the average miss probability of the improved Faster R-CNN model in this paper is decreased by 37.83%, 51.27%, and 43.79%, respectively, and average detection accuracy is increased by 3.6%, 9.75%, and 5.9%, respectively.
Interdecadal weakening of the cross-equatorial flows over the Maritime Continent during the boreal summer in the mid-1990s: drivers and physical processes
Authors: Zhao Xiaoxuan , Dong Buwen , Lu Riyu
Published: February 2021

In this study, the cross-equatorial flows (CEF) on both high and low level (HCEF/LCEF) troposphere over the Maritime Continent (MC) in boreal summer are found to have experienced an interdecadal weakening in the mid-1990s based on both JRA55 and NCEP reanalyses. The outputs of 8 coupled models in CMIP6 are used to investigate drivers and the corresponding mechanisms. Model results show that the role of external forcing is weak in the interdecadal weakening of CEF. By contrast, the observed interdecadal weakening of both HCEF and LCEF can be largely explained by internal variability associated with a negative phase of the interdecadal Pacific Oscillation (IPO). Associated with negative IPO are anomalous divergence (convergence), enhanced precipitation over MC and anomalous cyclonic (anticyclonic) circulations, reduced precipitation over western North Pacific (WNP) in the upper (lower) troposphere. Sensitivity experiments based on MetUM-GA6 further manifest that this IPO phase transition can lead to the interdecadal weakening of CEF, in which the central tropical Pacific (CTP) sea surface temperature (SST) anomalies play a dominant role. The cold SST anomalies in CTP lead to reduced local convection and trigger enhanced convection over MC through changes in the Walker circulation. The enhanced convection over MC leads to a change in local Hadley circulation over the western Pacific sector. This change is characterized by anomalous ascents over MC, southerlies in the upper troposphere, descents and reduced precipitation over WNP and northerlies in the lower troposphere, leading to the weakening of CEF. Meanwhile, positive SST anomalies over MC associated with negative IPO also make a contribution to the weakening of CEF by inducing a change in the Hadley circulation in the western Pacific sector through similar processes.
Oral antibiotic bowel decontamination in open and laparoscopic sigmoid resections for diverticular disease
Authors: Wirth Ulrich , Schardey Josefine , von Ahnen Thomas , Zimmermann Petra , Kühn Florian , Werner Jens , Schardey Hans Martin , Rau Bettina M. , Gumpp Julia
Published: February 2021

Purpose

There is an ongoing debate on whether or not to use oral antibiotic bowel decontamination in colorectal surgery, despite the numerous different regimens in terms of antibiotic substances and duration of application. As we routinely use oral antibiotic bowel decontamination (selective decontamination of the digestive tract (SDD) regimen and SDD regimen plus vancomycin since 2016) in surgery for diverticular disease, our aim was to retrospectively analyze the perioperative outcome in two independent centers.

Methods

Data from two centers with a routine use of oral antibiotic bowel decontamination for up to 20 years of experience were analyzed for the perioperative outcome of 384 patients undergoing surgery for diverticular disease.

Results

Overall morbidity was 12.8%, overall mortality was 0.3%, the overall rate of anastomotic leakage (AL) was 1.0%, and surgical site infections (SSIs) were 5.5% and 7.8% of all infectious complications including urinary tract infections and pneumonia. No serious adverse events were related to use of oral antibiotic bowel decontamination. Most of the patients (93.8%) completed the perioperative regimen. Additional use of vancomycin to the SDD regimen did not show a further reduction of infectious complications, including SSI and AL.

Conclusion

Oral antibiotic decontamination appears to be safe and effective with low rates of AL and infectious complications in surgery for diverticular disease.
COVID-19 im Alter – Die geriatrische Perspektive
Authors: Wirth R. , Becker C. , Djukic M. , Drebenstedt C. , Heppner H. J. , Jacobs A. H. , Meisel M. , Michels G. , Nau R. , Pantel J. , Bauer J. M.
Published: February 2021

Schwerwiegend verlaufende COVID-19-Erkrankungen betreffen vorwiegend die ältere Bevölkerung. Die Mortalität der hospitalisierten COVID-19-Patienten im Alter über 80 Jahre liegt international bei bis zu 54 %. Daher ist ein Blick auf die Erkrankung aus geriatrischer Perspektive erforderlich. Diagnostik und Therapie der COVID-19-Erkrankung unterscheiden sich bei den älteren Patienten nicht grundsätzlich von der bei jüngeren Patienten. Allerdings ist bei Patienten im hohen Alter gehäuft mit einer atypischen Symptomatik zu rechnen. Der Rehabilitationsbedarf nach durchgemachter Infektion ist bei älteren COVID-19-Patienten deutlich höher als bei jüngeren Patienten. Paradoxerweise steht der Notwendigkeit vermehrter Rehabilitationsleistungen jedoch ein sinkendes Angebot geriatrischer Rehabilitationsmöglichkeiten gegenüber, da viele Abteilungen entweder geschlossen oder deren Behandlungskapazitäten reduziert wurden. Generell sollten Quarantäne- und Isolationsmaßnahmen in der älteren Bevölkerung verstärkt auf ihre Verhältnismäßigkeit überprüft werden, da die gesundheitlichen und emotionalen Auswirkungen gravierend sein können. Angesichts der ungünstigen Prognose bei hochaltrigen COVID-19-Patienten kommt der Berücksichtigung des Patientenwillens eine besondere Bedeutung zu. Daher sollten Angehörige und Ärzte sich frühzeitig, d. h. möglichst bereits vor dem Auftreten einer Infektion, bemühen, diesen zu eruieren und angemessen zu dokumentieren. Erfreulicherweise lassen die bisherigen Daten hoffen, dass die Impfung mit den in Deutschland zugelassenen mRNA-Impfstoffen gegen SARS-CoV‑2 auch im hohen Alter gut wirksam ist.
Fertility preserving management of early endometrial cancer in a patient cohort at the department of women’s health at the university of Tuebingen
Authors: Andress Jürgen , Pasternak Jana , Walter Christina , Kommoss Stefan , Krämer Bernhard , Hartkopf Andreas , Brucker Sara Yvonne , Schönfisch Birgitt , Steinmacher Sahra
Published: February 2021

Purpose

To investigate the oncologic and reproductive outcome of a conservative treatment with progestin agents in early-stage grade 1 endometrial cancer (G1EC), grade 2 endometrial cancer (G2EC) or complex atypical hyperplasia (CAH) in young premenopausal women.

Methods

Women treated for early-stage endometrial cancer or atypical hyperplasia of the endometrium with a conservative therapy between 2006 and 2018 were enrolled in this retrospective analysis. Progestin agents were orally administered on a daily basis for 3 months for at least one cycle. Endometrial tissue was obtained by hysteroscopy and Dilatation & Curettage (D&C) being performed before and after end of treatment. Therapeutic response was assessed by pathological examination.

Results

A total of 14 patients were included. After treatment with progestin agents, 11 of these patients initially showed a complete or partial response. Three patients with early-stage endometrial cancer did not respond.

Of the three patients with initially diagnosed atypical hyperplasia, none showed any remaining disease later. Of the eight patients with initially diagnosed endometrial cancer, who had responded to first treatment, three patients were re-diagnosed with endometrial cancer later. One patient with initial endometrial cancer became pregnant but aborted in the 10th week.

Conclusion

Due to its good efficacy, progestin agents offer a feasible therapeutic option in the fertility-preserving treatment of early-stage endometrial cancer in young premenopausal women. However, recurrence rate remains high. Therefore, a close follow-up is mandatory, also in responders. Patients should be informed of limitations and risks of conservative treatment. Yet after completion of family planning, hysterectomy should be performed.
Ontogenetic development of the shoulder joint muscles in frogs (Amphibia: Anura) assessed by digital dissection with implications for interspecific muscle homologies and nomenclature
Authors: Engelkes Karolin , Panpeng Supak , Haas Alexander
Published: February 2021

Previous myological studies show inconsistencies with regard to the identification and naming of the shoulder joint muscles in frogs and toads (Amphibia: Anura). Those inconsistencies were revealed and resolved by assessing the ontogenetic development, innervation, and adult morphology of selected anuran species representing ancient lineages and two major neobatrachian groups. To do so, digital dissections of volumes acquired by histological serial sectioning, episcopic microtomy, and contrast-enhanced micro-computed tomography scanning were performed and three-dimensional reconstructions were derived. Muscle units crossing the shoulder joint were defined, their ontogenetic development was described, their homology across species was established, and a consistent nomenclature was suggested. The mm. anconaeus, dorsalis scapulae, latissimus dorsi, and the group of scapulohumeralis muscles were ontogenetically derived from the dorsal pre-muscle mass present in all tetrapods. The ventral pre-muscle mass gave rise to the mm. cleidohumeralis, episternohumeralis, supracoracoideus, coracoradialis, subcoracoscapularis, coracobrachialis, and pectoralis. The results indicate that the mm. anconaeus, dorsalis scapulae, latissimus dorsi, coracoradialis, and the portionis sternalis and abdominalis of the m. pectoralis have consistently been recognized and denoted in previous studies, whereas the names for the muscle units commonly denoted as m. coraco-brachialis longus and as parts of the m. deltoideus are misleading with regard to the ontogenetic origin of these muscles. The mm. scapulohumeralis profundus anterior and posterior, although present, have been overlooked in some studies. The mm. cleidohumeralis, supracoracoideus, and coracobrachialis are present with two parts or portions in some species, these portions have previously not always been recognized and assigned correctly.
T helper cell trafficking in autoimmune kidney diseases
Authors: Riedel Jan-Hendrik , Turner Jan-Eric , Panzer Ulf
Published: February 2021

CD4+T cells are key drivers of autoimmune diseases, including crescentic GN. Many effector mechanisms employed by T cells to mediate renal damage and repair, such as local cytokine production, depend on their presence at the site of inflammation. Therefore, the mechanisms regulating the renal CD4+T cell infiltrate are of central importance. From a conceptual point of view, there are four distinct factors that can regulate the abundance of T cells in the kidney: (1) T cell infiltration, (2) T cell proliferation, (3) T cell death and (4) T cell retention/egress. While a substantial amount of data on the recruitment of T cells to the kidneys in crescentic GN have accumulated over the last decade, the roles of T cell proliferation and death in the kidney in crescentic GN is less well characterized. However, the findings from the data available so far do not indicate a major role of these processes. More importantly, the molecular mechanisms underlying both egress and retention of T cells from/in peripheral tissues, such as the kidney, are unknown. Here, we review the current knowledge of mechanisms and functions of T cell migration in renal autoimmune diseases with a special focus on chemokines and their receptors.
Improved Online Algorithms for Knapsack and GAP in the Random Order Model
Authors: Albers Susanne , Khan Arindam , Ladewig Leon
Published: February 2021

The knapsack problem is one of the classical problems in combinatorial optimization: Given a set of items, each specified by its size and profit, the goal is to find a maximum profit packing into a knapsack of bounded capacity. In the online setting, items are revealed one by one and the decision, if the current item is packed or discarded forever, must be done immediately and irrevocably upon arrival. We study the online variant in the random order model where the input sequence is a uniform random permutation of the item set. We develop a randomized (1/6.65)-competitive algorithm for this problem, outperforming the current best algorithm of competitive ratio 1/8.06 (Kesselheim et al. in SIAM J Comput 47(5):1939–1964, 2018). Our algorithm is based on two new insights: We introduce a novel algorithmic approach that employs two given algorithms, optimized for restricted item classes, sequentially on the input sequence. In addition, we study and exploit the relationship of the knapsack problem to the 2-secretary problem. The generalized assignment problem (GAP) includes, besides the knapsack problem, several important problems related to scheduling and matching. We show that in the same online setting, applying the proposed sequential approach yields a (1/6.99)-competitive randomized algorithm for GAP. Again, our proposed algorithm outperforms the current best result of competitive ratio 1/8.06 (Kesselheim et al. in SIAM J Comput 47(5):1939–1964, 2018).
Two Remarks on Graph Norms
Authors: Garbe Frederik , Hladký Jan , Lee Joonkyung
Published: February 2021

For a graph H, its homomorphism density in graphs naturally extends to the space of two-variable symmetric functions W in $$L^p$$

L
p

, $$p\ge e(H)$$

p
≥
e
(
H
)

, denoted by t(H, W). One may then define corresponding functionals $$\Vert W\Vert _{H}\,{:}{=}\,|t(H,W)|^{1/e(H)}$$

‖
W
‖

H

:
=

|
t

(
H
,
W
)

|

1
/
e
(
H
)

and $$\Vert W\Vert _{r(H)}\,{:}{=}\,t(H,|W|)^{1/e(H)}$$

‖
W
‖

r
(
H
)

:
=

t

(
H
,
|
W
|
)

1
/
e
(
H
)

, and say that H is (semi-)norming if $$\Vert \,{\cdot }\,\Vert _{H}$$

‖

·

‖

H

is a (semi-)norm and that H is weakly norming if $$\Vert \,{\cdot }\,\Vert _{r(H)}$$

‖

·

‖

r
(
H
)

is a norm. We obtain two results that contribute to the theory of (weakly) norming graphs. Firstly, answering a question of Hatami, who estimated the modulus of convexity and smoothness of $$\Vert \,{\cdot }\,\Vert _{H}$$

‖

·

‖

H

, we prove that $$\Vert \,{\cdot }\,\Vert _{r(H)}$$

‖

·

‖

r
(
H
)

is neither uniformly convex nor uniformly smooth, provided that H is weakly norming. Secondly, we prove that every graph H without isolated vertices is (weakly) norming if and only if each component is an isomorphic copy of a (weakly) norming graph. This strong factorisation result allows us to assume connectivity of H when studying graph norms. In particular, we correct a negligence in the original statement of the aforementioned theorem by Hatami.
Validation of the Italian Version of the Functional Oral Intake Scale (FOIS-It) Against Fiberoptic Endoscopic Evaluation of Swallowing and Nutritional Status
Authors: Ninfa Aurora , Pizzorni Nicole , Eplite Angelo , Moltisanti Claudia , Schindler Antonio
Published: February 2021

The Functional Oral Intake Scale (FOIS) is a reliable and valid tool to assess functional oral intake of food and liquids in patients with oropharyngeal dysphagia (OD). Its validity was established for stroke patients against Videofluoroscopic Swallowing Study in English and Chinese and against Fiberoptic Endoscopic Evaluation of Swallowing (FEES) in German. FOIS was cross-culturally validated into Italian (FOIS-It), but construct validity against instrumental assessment and nutritional status was not investigated. The study aims at contributing to the validation of the FOIS-It, by performing convergent and known-group validity against FEES and nutritional status in patients with OD of different etiologies. Overall, 220 adult patients with OD of etiological heterogeneity were recruited. FOIS-It score and Body Mass Index (BMI) were collected. FEES was performed to assess swallowing safety and efficiency based on the Penetration-Aspiration Scale (PAS) and the Yale Pharyngeal Residue Severity Rating Scale (YPRSRS). Moderate to weak associations with PAS (ρ = − .37, p < .01), YPRSRS in the pyriform sinuses (ρ = − .20, p < .01), and BMI (ρ = .24, p < .01) were detected with Spearman’s correlation. FOIS-It distribution was compared with the Mann–Whitney U and Kruskal–Wallis tests. Significantly lower FOIS-It scores were detected among patients with penetration/aspiration (PAS > 2) and penetration (PAS > 2 ≤ 5) for all consistencies (p < .01), aspiration (PAS > 5) of liquids and semisolids (p < .001), residue in the pyriform sinuses (YPRSRS > 3) with semisolids (p < .001) and solids (p = .02), and malnutrition (BMI ≤ 18.5; p = .019). FOIS-It appears as a valid tool to assess functional oral intake against FEES’ measures of swallowing safety and efficiency and nutritional status in patients with OD of etiological heterogeneity.
Early clinical management of autosomal recessive polycystic kidney disease
Authors: Liebau Max Christoph
Published: February 2021

Autosomal recessive polycystic kidney disease (ARPKD) is a rare but highly relevant disorder in pediatric nephrology. This genetic disease is mainly caused by variants in the PKHD1 gene and is characterized by fibrocystic hepatorenal phenotypes with major clinical variability. ARPKD frequently presents perinatally, and the management of perinatal and early disease symptoms may be challenging. This review discusses aspects of early manifestations in ARPKD and its clincial management with a special focus on kidney disease.
Untersuchung eines Doppelspitzschlägels aus dem römerzeitlichen Marmorsteinbruchrevier Spitzelofen in Kärnten, Österreich
Authors: Scheiblechner Wolfgang , Karl Stephan , Modl Daniel , Strobl Susanne , Haubner Roland
Published: February 2021

Ein Doppelspitzschlägel aus dem römerzeitlichen Marmorsteinbruchrevier Spitzelofen in Kärnten wurde untersucht, um dessen Herstellung und Einsatz bei der Marmorbearbeitung beurteilen zu können.

Das Eisen wurde in Form von Luppen aus Rennfeuern erhalten. Inhomogene Kohlenstoffverteilungen im Schlägel können auf die Eisenherstellung im Rennfeuer sowie die Verarbeitung durch Schmieden zurückgeführt werden. Das Eisen des Doppelspitzschlägels besteht weitgehend aus Stahl mit eutektoidem (0,8 % C) Kohlenstoffgehalt, wobei vor allem an der Spitze ein Gradient zu fast reinem Ferrit beobachtet wurde. Es wurden die erwarteten Stahlgefüge, wie Perlit, Zwischenstufe, Widmannstättscher Ferrit und Ferrit, gefunden, jedoch kein Martensit. Um dies abzuklären, wurden Spitzen nachgeschmiedet und gehärtet, wobei auch hier kein Martensit an den Oberflächen der Spitzen nachgewiesen werden konnte.

Versuche zur Marmorbearbeitung mit einem nachgeschmiedeten Doppelspitzschlägel zeigten, dass eine regelmäßige Nachbearbeitung der Werkzeuge notwendig war, was auch die im Steinbruchrevier gefundenen Schmiedeplätze erklärt.
Navigated iliac screw placement may reduce radiation and OR time in lumbopelvic fixation of unstable complex sacral fractures
Authors: Hoffmann M. F. , Yilmaz E. , Norvel D. C. , Schildhauer T. A.
Published: February 2021

Purpose

Instability of the posterior pelvic ring may be stabilized by lumbopelvic fixation. The optimal osseous corridor for iliac screw placement from the posterior superior iliac spine to the anterior inferior iliac spine requires multiple ap- and lateral-views with additional obturator-outlet and -inlet views.

The purpose of this study was to determine if navigated iliac screw placement for lumbopelvic fixation influences surgical time, fluoroscopy time, radiation exposure, and complication rates.

Methods

Bilateral lumbopelvic fixation was performed in 63 patients. Implants were inserted as previously described by Schildhauer. A passive optoelectronic navigation system with surface matching on L4 was utilized for navigated iliac screw placement. To compare groups, demographics were assessed. Operative time, fluoroscopic time, and radiation were delineated.

Results

Conventional fluoroscopic imaging for lumbopelvic fixation was performed in 32 patients and 31 patients underwent the procedure with navigated iliac screw placement. No differences were found between the groups regarding demographics, comorbidities, or additional surgical procedures.

Utilization of navigation led to fluoroscopy time reduction of more than 50% (3.2 vs. 8.6 min.; p < 0.001) resulting in reduced radiation (2004.5 vs. 5130.8 Gy*cm2; p < 0.001). Operative time was reduced in the navigation group (176.7 vs. 227.4 min; p = 0.002) despite the necessity of additional surface referencing.

Conclusion

For iliac screws, identifying the correct entry point and angle of implantation requires detailed anatomic knowledge and multiple radiographic views. In our study, additional navigation reduced operative time and fluoroscopy time resulting in a significant reduction of radiation exposure for patients and OR personnel.
Lactoferrin affects rhinovirus B-14 entry into H1-HeLa cells
Authors: Denani Caio Bidueira , Real-Hohn Antonio , de Carvalho Carlos Alberto Marques , Gomes Andre Marco de Oliveira , Gonçalves Rafael Braga
Published: February 2021

Lactoferrin is part of the innate immune system, with antiviral activity against numerous DNA and RNA viruses. Rhinoviruses, the leading cause of the common cold, are associated with exacerbation of respiratory illnesses such as asthma. Here, we explored the effect of bovine lactoferrin (BLf) on RV-B14 infectivity. Using different assays, we show that the effect of BLf is strongest during adhesion of the virus to the cell and entry. Tracking the internalisation of BLf and virus revealed a degree of colocalisation, although their interaction was only confirmed in vitro using empty viral particles, indicating a possible additional influence of BLf on other infection steps.
A structured pathway for developing your complex abdominal hernia service: our York pathway
Authors: Smith O. , MacLeod T. , Lim P. , Chitsabesan P. , Chintapatla S.
Published: February 2021

Purpose

Clinical pathways are widely prevalent in health care and may be associated with increased clinical efficacy, improved patient care, streamlining of services, while providing clarity on patient management. Such pathways are well established in several branches of healthcare services but, to the authors’ knowledge, not in complex abdominal wall reconstruction (CAWR). A stepwise, structured and comprehensive approach to managing complex abdominal wall hernia (CAWH) patients, which has been successfully implemented in our practice, is presented.

Methods

A literature search of common databases including Embase® and MEDLINE® for CAWH pathways identified no comprehensive pathway. We therefore undertook a reiterative process to develop the York Abdominal Wall Unit (YAWU) through examination of current evidence and logic to produce a pragmatic redesign of our own pathway. Having introduced our pathway, we then performed a retrospective analysis of the complexity and number of abdominal wall cases performed in our trust over time.

Results

We describe our pathway and demonstrate that the percentage of cases and their complexity, as defined by the VHWG classification, have increased over time in York Abdominal Wall Unit.

Conclusion

A structured pathway for complex abdominal wall hernia service is one way to improve patient experience and streamline services. The relevance of pathways for the hernia surgeon is discussed alongside this pathway. This may provide a useful guide to those wishing to establish similar personalised pathways within their own units and allow them to expand their service.
Sweetness profiles of glycosylated rebaudioside A and its binary mixtures with allulose and maltitol
Authors: Jung Jinsil , Kim SooHyun , Park Sunghee , Hong Jae-Hee
Published: February 2021

Rebaudioside A is a promising natural alternative sweetener but they produce increased bitterness, astringency, and unpleasant aftertastes. Glycosylation and blending with different sweeteners are known to improve the sensory characteristics of rebaudioside A. The present study was conducted to identify the relative sweetness and sensory profile of glycosyl rebaudioside A (g-reb A). The relative sweetness of g-reb A compared to 5% sucrose was determined using the two-alternative forced choice method. The sensory profiles of g-reb A and its mixtures with allulose and maltitol (1:1 ratio) were compared to those of rebaudioside A, rebaudioside D, rebaudioside M, sucralose, allulose, maltitol, and sucrose using descriptive analysis conducted by eight trained panelists. The relative sweetness of g-reb A was 155, which was lower than that of rebaudioside A. In addition, the bitter taste and aftertaste, astringency, and sweet onset of g-reb A were decreased compared to those of rebaudioside A.
Extraction of volatile organic compounds from leaves of Ambrosia artemisiifolia L. and Artemisia annua L. by headspace-solid phase micro extraction and simultaneous distillation extraction and analysis by gas chromatography/mass spectrometry
Authors: Son Ji Hyeon , Islam Md Atikul , Hong Joon Ho , Jeong Ji Young , Song Ok Yeon , Kim Hui Eun , Khan Naeem , Jamila Nargis , Kim Kyong Su
Published: February 2021

This study was designed to analyze the volatile organic compounds in the leaves of Ambrosia artemisiifolia L. and Artemisia annua L. from Korea. For extraction of volatile compounds, headspace-solid phase micro extraction (HS-SPME) and simultaneous distillation extraction (SDE) were applied and analyzed by gas chromatography/mass spectrometry (GC/MS). From the results, SDE extraction was found to give the highest concentration of volatile compounds with an average concentration of 1,237.79 mg/kg for A. annua L. leaves compared to 1,122.73 mg/kg by HS-SPME technique. A total of 116 volatile organic compounds were identified, including 76 similar volatile organic compounds detected by both the methods of extraction in leaves of subject species at varying concentrations. Among these 33 volatile organic compounds were reported for the first time from the subject plant species. Thus the present research findings extend the characterization of volatile organic compounds from leaves of A. annua L. and A. artemisiifolia L. species and reported some distinguishing compounds which may be used for their discrimination.
Fast-track identification of CTX-M-extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacterales in bloodstream infections: implications on the likelihood of deduction of antibiotic susceptibility in emergency and internal medicine departments
Authors: Boattini Matteo , Bianco Gabriele , Iannaccone Marco , Ghibaudo Davide , Almeida André , Cavallo Rossana , Costa Cristina
Published: February 2021

This study aims at presenting a reliable fast-track diagnostics for the detection of CTX-M ESBL- (CTX-M-p) and carbapenemase-producers (CA-p) directly from blood cultures (BCs) of patients with Enterobacterales (EB) bloodstream infections (BSIs) admitted in emergency and internal medicine departments and its contribution in estimation of in vitro antibiotic susceptibility. A fast-track workflow including MALDI-TOF species identification and two lateral flow immunochromatographic assays for the detection of CTX-M-p and CA-p directly from BCs was performed in parallel with conventional routine, and results were compared. A total of 236 BCs of patients suffering from EB BSI were included. Accuracy of the fast-track workflow ranged from 99.6 to 100%. Among E. coli isolates, CTX-M-p (20.5%) were susceptible to ceftolozane-tazobactam (C/T, 97%), ceftazidime-avibactam (CZA, 100%), and piperacillin-tazobactam (TZP, 84.8%), whereas CTX-M-and-main-carbapenemases-non-producer (CTX-M-CA-np, 79.5%) isolates were susceptible to all the antibiotics tested. Among K. pneumoniae isolates, CTX-M-p (23.3%) were poorly susceptible to TZP (40%) but widely susceptible to C/T (90%), CZA (100%), and amikacin (90%), whereas CTX-M-CA-np (55.8%) were also susceptible to cefepime. CA-p K. pneumoniae (20.9%) were susceptible to CZA (88.9%). All the species other than E. coli and K. pneumoniae were CTX-M-CA-np and were widely susceptible to the antibiotics tested except for isolates of the inducible and derepressed AmpC- or AmpC/ESBL-p species. Rapid identification of species and phenotype together with knowledge of local epidemiology may be crucial to determine the likelihood of deduction of in vitro antibiotic susceptibility on the same day of positive BC processing.
Competence-based assignment of tasks to workers in factories with demand-driven manufacturing
Authors: Staruch Bożena , Staruch Bogdan
Published: February 2021

The paper is motivated by real problems concerning tasks assignment to workers in medium-sized upholstered furniture plants managed using the Demand-Driven Manufacturing. Although the methodology was developed for furniture plants it can be applied to other types of production plants. We involve competence coefficients, which describe the level of the worker’s skills or capabilities to perform a specific task. The competence coefficients are also used to block the possibility of assigning the given task to a worker that has no skills to do it. Additionally, we involve a dummy worker to the model which guarantees the existence of a solution to the problem. We present and discuss Integer Linear Programming Models for the posted problem that are closely related to the Generalized Assignment Problem. We also discuss the potential use of the presented methodology to solve real-life problems related to production management.
A systematic review of the quality of reporting of interventions in the surgical treatment of Crohn’s anal fistula: an assessment using the TIDiER and Blencowe frameworks
Authors: Tyrell S. , Coates E. , Brown Steven R. , Lee M. J.
Published: February 2021

Background

Crohn’s anal fistula is a challenging condition, and may require multiple surgical procedures. To replicate successful procedures, these must be adequately reported in the literature. The aim of this study was to review the quality of reporting of components of surgical interventions for Crohn’s anal fistula.

Methods

A systematic review was conducted. It was registered with PROSPERO (CRD:42019135157). The Medline and EMBASE databases were searched for studies reporting interventions intended to close fistula in patients with Crohn’s disease, published between 1999 and August 2019. Abstracts and full texts were screened for inclusion by two reviewers. Dual extraction of data was performed to compare reporting to the TIDiER and Blencowe frameworks for reporting of interventions.

Results

Initial searches identified 207 unique studies; 38 full texts were screened for inclusion and 33 were included. The most common study design was retrospective cohort (17/33), and the most frequently reported interventions were anal fistula plug (n = 8) and fibrin glue (n = 6). No studies showed coverage of all domains of TIDieR. Reporting was poor among domains related to who provided an intervention, where it was provided, and how it was tailored. Reporting of domains in the Blencowe framework was poor; the majority of studies did not report the component steps of procedures or efforts to standardise them.

Conclusions

This study demonstrates that reporting on technical aspects of interventions for Crohn’s anal fistula is poor. Surgeons should aim to improve reporting to allow accurate reproduction of techniques both in clinical practice and in clinical trials.
Model-driven engineering city spaces via bidirectional model transformations
Authors: Visconti Ennio , Tsigkanos Christos , Hu Zhenjiang , Ghezzi Carlo
Published: February 2021

Engineering cyber-physical systems inhabiting contemporary urban spatial environments demands software engineering facilities to support design and operation. Tools and approaches in civil engineering and architectural informatics produce artifacts that are geometrical or geographical representations describing physical spaces. The models we consider conform to the CityGML standard; although relying on international standards and accessible in machine-readable formats, such physical space descriptions often lack semantic information that can be used to support analyses. In our context, analysis as commonly understood in software engineering refers to reasoning on properties of an abstracted model—in this case a city design. We support model-based development, firstly by providing a way to derive analyzable models from CityGML descriptions, and secondly, we ensure that changes performed are propagated correctly. Essentially, a digital twin of a city is kept synchronized, in both directions, with the information from the actual city. Specifically, our formal programming technique and accompanying technical framework assure that relevant information added, or changes applied to the domain (resp. analyzable) model are reflected back in the analyzable (resp. domain) model automatically and coherently. The technique developed is rooted in the theory of bidirectional transformations, which guarantees that synchronization between models is consistent and well behaved. Produced models can bootstrap graph-theoretic, spatial or dynamic analyses. We demonstrate that bidirectional transformations can be achieved in practice on real city models.
Early EEG Alterations Correlate with CTP Hypoperfused Volumes and Neurological Deficit: A Wireless EEG Study in Hyper-Acute Ischemic Stroke
Authors: Ajčević Miloš , Furlanis Giovanni , Miladinović Aleksandar , Buoite Stella Alex , Caruso Paola , Ukmar Maja , Cova Maria Assunta , Naccarato Marcello , Accardo Agostino , Manganotti Paolo
Published: February 2021

Brain electrical activity in acute ischemic stroke is related to the hypoperfusion of cerebral tissue as manifestation of neurovascular coupling. EEG could be applicable for bedside functional monitoring in emergency settings. We aimed to investigate the relation between hyper-acute ischemic stroke EEG changes, measured with bedside wireless-EEG, and hypoperfused core-penumbra CT-perfusion (CTP) volumes. In addition, we investigated the association of EEG and CTP parameters with neurological deficit measured by NIHSS. We analyzed and processed EEG, CTP and clinical data of 31 anterior acute ischemic stroke patients registered within 4.5 h from symptom onset. Delta/alpha ratio (DAR), (delta + theta)/(alpha + beta) ratio (DTABR) and relative delta power correlated directly (ρ = 0.72; 0.63; 0.65, respectively), while alpha correlated inversely (ρ = − 0.66) with total hypoperfused volume. DAR, DTBAR and relative delta and alpha parameters also correlated with ischemic core volume (ρ = 0.55; 0.50; 0.59; − 0.51, respectively). The same EEG parameters and CTP volumes showed significant relation with NIHSS at admission. The multivariate stepwise regression showed that DAR was the strongest predictor of NIHSS at admission (p < 0.001). The results of this study showed that hyper-acute alterations of EEG parameters are highly related to the extent of hypoperfused tissue highlighting the value of quantitative EEG as a possible complementary tool in the evaluation of stroke severity and its potential role in acute ischemic stroke monitoring.
A generalised complete flux scheme for anisotropic advection-diffusion equations
Authors: Cheng Hanz Martin , Boonkkamp Jan ten Thije
Published: February 2021

In this paper, we consider separating the discretisation of the diffusive and advective fluxes in the complete flux scheme. This allows the combination of several discretisation methods for the homogeneous flux with the complete flux (CF) method. In particular, we explore the combination of the hybrid mimetic mixed (HMM) method and the CF method, in order to utilise the advantages of each of these methods. The usage of HMM allows us to handle anisotropic diffusion tensors on generic polygonal (polytopal) grids, whereas the CF method provides a framework for the construction of a uniformly second-order method, even when the problem is advection dominated.
Space and Place. A Morphological Perspective
Authors: Furia Paolo
Published: February 2021

The morphological account of landscape aims to overcome the contrast between an objectivist/scientific account of space and the more qualitative/subjective account of place. It does so by actualizing the notion of landscape, which endows a materiality often overlooked in contemporary spatial theories. In this paper, I will discuss what has been called the ‘space-place conundrum’ by referring mostly to the human geography contemporary debate on space and place. In the following, I will retrieve Carl Sauer’s morphological conception of landscape as an alternative framework aimed at rephrasing both the concepts of space and place. Landscape must be freed from the cage of the aesthetic gaze so that it can be understood as a lived and dynamic complex of interacting forms that encompass the embodied subject. In the end, I will outline the main characteristics of a morphological conception of landscape, paving the way for further inquiries.
The impact of age on patient-reported outcomes after oncoplastic versus conventional breast cancer surgery
Authors: Ritter M. , Ling B. M. , Oberhauser I. , Montagna G. , Zehnpfennig L. , Lévy J. , Soysal S. D. , Castrezana L. López , Müller M. , Schwab F. D. , Kurzeder C. , Haug M. , Weber W. P. , Kappos E. A.
Published: February 2021

Purpose

Some studies have indicated age-specific differences in quality of life (QoL) among breast cancer (BC) patients. The aim of this study was to compare patient-reported outcomes after conventional and oncoplastic breast surgery in two distinct age groups.

Methods

Patients who underwent oncoplastic and conventional breast surgery for stage I-III BC, between 6/2011–3/2019, were identified from a prospectively maintained database. QoL was prospectively evaluated using the Breast-Q questionnaire. Comparisons were made between women < 60 and ≥ 60 years.

Results

One hundred thirty-three patients were included. Seventy-three of them were ≥ 60 years old. 15 (20.5%) of them received a round-block technique (RB) / oncoplastic breast-conserving surgeries (OBCS), 10 (13.7%) underwent nipple-sparing mastectomies (NSM) with deep inferior epigastric perforator flap (DIEP) reconstruction, 23 (31.5%) underwent conventional breast-conserving surgeries (CBCS), and 25 (34.2%) received total mastectomy (TM). Sixty patients were younger than 60 years, 15 (25%) thereof received RB/OBCS, 22 (36.7%) NSM/DIEP, 17 (28.3%) CBCS, and 6 (10%) TM. Physical well-being chest and psychosocial well-being scores were significantly higher in older women compared to younger patients (88.05 vs 75.10; p < 0.001 and 90.46 vs 80.71; p = 0.002, respectively). In multivariate linear regression, longer time intervals had a significantly positive effect on the scales Physical Well-being Chest (p = 0.014) and Satisfaction with Breasts (p = 0.004). No significant results were found concerning different types of surgery.

Conclusion

Our findings indicate that age does have a relevant impact on postoperative QoL. Patient counseling should include age-related considerations, however, age itself cannot be regarded as a contraindication for oncoplastic surgery.
Adversity Tries Friends: A Multilevel Analysis of Corporate Philanthropic Response to the Local Spread of COVID-19 in China
Authors: Chen Hanwen , Liu Siyi , Liu Xin , Yang Daoguang
Published: February 2021

We examine corporate philanthropic decisions in response to the local spread of COVID-19. From a strategic perspective, firms may proactively undertake philanthropic efforts to limit the spread of the pandemic and avoid a degraded business environment. From the perspective of non-trivial costs, increased economic uncertainty can raise concerns about business survival and lead to conservative philanthropic strategies. Following the proverb “prosperity makes friends, adversity tries them,” at the provincial level, our results support the second perspective. Specifically, when the spread of the pandemic worsens in a province, local firms are less likely to make COVID-19-related donations in terms of likelihood and amount. Investors also react negatively, not only to the local spread of COVID-19 but also to COVID-19-related philanthropic donations. At the organizational level, our evidence indicates that there is at least some level of cost–benefit analysis underlying corporate philanthropic decisions. Specifically, corporate philanthropic donations, especially those made to the local business environment, are significantly affected by organizational-level factors, such as pre-existing resource availability and motives to acquire political and reputational resources. Overall, our multilevel study presents a comprehensive picture of corporate philanthropic decisions amid the COVID-19 crisis.
Re-framing the threat of global warming: an empirical causal loop diagram of climate change, food insecurity and societal collapse
Authors: Richards C. E. , Lupton R. C. , Allwood J. M.
Published: February 2021

There is increasing concern that climate change poses an existential risk to humanity. Understanding these worst-case scenarios is essential for good risk management. However, our knowledge of the causal pathways through which climate change could cause societal collapse is underdeveloped. This paper aims to identify and structure an empirical evidence base of the climate change, food insecurity and societal collapse pathway. We first review the societal collapse and existential risk literature and define a set of determinants of societal collapse. We develop an original methodology, using these determinants as societal collapse proxies, to identify an empirical evidence base of climate change, food insecurity and societal collapse in contemporary society and then structure it using a novel-format causal loop diagram (CLD) defined at global scale and national granularity. The resulting evidence base varies in temporal and spatial distribution of study and in the type of data-driven methods used. The resulting CLD documents the spread of the evidence base, using line thickness and colour to depict density and type of data-driven method respectively. It enables exploration of how the effects of climate change may undermine agricultural systems and disrupt food supply, which can lead to economic shocks, socio-political instability as well as starvation, migration and conflict. Suggestions are made for future work that could build on this paper to further develop our qualitative understanding of, and quantitative complex systems modelling capabilities for analysing, the causal pathways between climate change and societal collapse.
The Bundle Theory Approach to Relational Quantum Mechanics
Authors: Oldofredi Andrea
Published: February 2021

The present essay provides a new metaphysical interpretation of Relational Quantum Mechanics (RQM) in terms of mereological bundle theory. The essential idea is to claim that a physical system in RQM can be defined as a mereological fusion of properties whose values may vary for different observers. Abandoning the Aristotelian tradition centered on the notion of substance, I claim that RQM embraces an ontology of properties that finds its roots in the heritage of David Hume. To this regard, defining what kind of concrete physical objects populate the world according to RQM, I argue that this theoretical framework can be made compatible with (i) a property-oriented ontology, in which the notion of object can be easily defined, and (ii) moderate structural realism, a philosophical position where relations and relata are both fundamental. Finally, I conclude that under this reading relational quantum mechanics should be included among the full-fledged realist interpretations of quantum theory.
The Effect of Different Flaw Data to Machine Learning Powered Ultrasonic Inspection
Authors: Koskinen Tuomas , Virkkunen Iikka , Siljama Oskar , Jessen-Juhler Oskari
Published: February 2021

Previous research (Li et al., Understanding the disharmony between dropout and batch normalization by variance shift. CoRR abs/1801.05134 (2018).http://arxiv.org/abs/1801.05134arXiv:1801.05134) has shown the plausibility of using a modern deep convolutional neural network to detect flaws from phased-array ultrasonic data. This brings the repeatability and effectiveness of automated systems to complex ultrasonic signal evaluation, previously done exclusively by human inspectors. The major breakthrough was to use virtual flaws to generate ample flaw data for the teaching of the algorithm. This enabled the use of raw ultrasonic scan data for detection and to leverage some of the approaches used in machine learning for image recognition. Unlike traditional image recognition, training data for ultrasonic inspection is scarce. While virtual flaws allow us to broaden the data considerably, original flaws with proper flaw-size distribution are still required. This is of course the same for training human inspectors. The training of human inspectors is usually done with easily manufacturable flaws such as side-drilled holes and EDM notches. While the difference between these easily manufactured artificial flaws and real flaws is obvious, human inspectors still manage to train with them and perform well in real inspection scenarios. In the present work, we use a modern, deep convolutional neural network to detect flaws from phased-array ultrasonic data and compare the results achieved from different training data obtained from various artificial flaws. The model demonstrated good generalization capability toward flaw sizes larger than the original training data, and the effect of the minimum flaw size in the data set affects the$$a_{90/95}$$a90/95value. This work also demonstrates how different artificial flaws, solidification cracks, EDM notch and simple simulated flaws generalize differently.