bluuebunny/crossref_metadata_2025 huggingface dataset:
Acral Lentiginous Melanoma of the Thumb: Dermoscopy and Treatment
Authors: Tammaro Antonella , Adebanjo Ganiyat Adenike Ralitsa , Sorotos Michail , Cantisani Carmen , Chello Camilla , Erasmus Hans Peter , Grippaudo Francesca Romana , Santanelli Di Pompeo Fabio , Pellacani Giovanni
Published: September 2023

Melanoma affecting glabrous skin is a challenging entity that needs to be managed by an interdisciplinary team of dermatologists, oncologists, and surgeons. The thin subcutaneous layer of glabrous skin, which speeds up its metastatic spread, is one of the key elements that contributes to the aggressiveness of this form of cutaneous cancer when identified in this anatomical region. Acral lentiginous melanoma is a rare melanocytic malignancy that is usually associated with ominous outcomes, especially in those with dark skin. Moreover, more extensive research is needed to elucidate the puzzle of molecular drivers and their relationship with thermal injury. We reported our experience in order to highlight the value of timely diagnosis and treatment.
Computed Tomography Pulmonary Angiography Prediction of Adverse Long-Term Outcomes in Chronic Thromboembolic Pulmonary Hypertension: Correlation with Hemodynamic Measurements Pre- and Post-Pulmonary Endarterectomy
Authors: Gopalan Deepa , Riley Jan Y. J. , Leong Kai’en , Alsanjari Senan , Auger William , Lindholm Peter
Published: September 2023

CT pulmonary angiography is commonly used in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). This work was conducted to determine if cardiac chamber size on CTPA may also be useful for predicting the outcome of CTEPH treatment. A retrospective analysis of paired CTPA and right heart hemodynamics in 33 consecutive CTEPH cases before and after pulmonary thromboendarterectomy (PTE) was performed. Semiautomated and manual CT biatrial and biventricular size quantifications were correlated with mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR) and cardiac output. The baseline indexed right atrioventricular volumes were twice the left atrioventricular volumes, with significant (p < 0.001) augmentation of left heart filling following PTE. Except for the left atrial volume to cardiac index, all other chamber ratios significantly correlated with hemodynamics. Left to right ventricular ratio cut point <0.82 has high sensitivity (91% and 97%) and specificity (88% and 85%) for identifying significant elevations of mPAP and PVR, respectively (AUC 0.90 and 0.95), outperforming atrial ratios (sensitivity 78% and 79%, specificity 82% and 92%, and AUC 0.86 and 0.91). Manual LV:RV basal dimension ratio correlates strongly with semiautomated volume ratio (r 0.77, 95% CI 0.64–0.85) and is an expeditious alternative with comparable prognostic utility (AUC 0.90 and 0.95). LV:RV dimension ratio of <1.03 and ≤0.99 (alternatively expressed as RV:LV ratio of >0.97 and ≥1.01) is a simple metric that can be used for CTEPH outcome prediction.
Tungiasis: Participation of Cats and Chickens in the Dispersion and Maintenance of the Disease in an Endemic Tourist Area in Brazil
Authors: Teixeira Jamille Bispo de Carvalho , dos Santos Katharine Costa , Guedes Paula Elisa Brandão , Vitor Rebeca Costa , Bitar Thammy Vieira , Harvey Tatiani Vitor , Sevá Anaiá da Paixão , Carlos Renata Santiago Alberto
Published: September 2023

Tunga spp. are fleas commonly found in impoverished tropical regions. In Vila Juerana, a tourist community in Ilheus, Bahia, Brazil, where tungiasis is endemic, dogs are the main host of fleas during their life cycle. However, there is no information about the role of cats and chickens in tungiasis in the village. Of the 272 households investigated, 112 had domestic animals, 48 had only dogs, 28 had only cats, and nine had only chickens. Of the 27 households with cohabitation among species, 16 had cats and dogs, eight had chickens and dogs, and three had dogs, cats, and chickens. The injuries due to tungiasis were ranked according to the Fortaleza classification, considering stages I, II, and III as viable lesions. The paws/feet of 71/111 (63.9%) cats and 173/439 (39.4%) chickens were inspected. Dogs that lived with positive cats and chickens also were inspected. Among the 38% (27/7; 95% IC 26.74–49.32) positive cats, 16 cohabited houses with infected dogs but none lived with positive chickens. Of the chickens, 2.3% (4/173; 95% IC 0.07–4.5) had lesions caused by tungiasis. In each household where a cat was infected, the dog was also positive. Two chickens cohabited with an infected dog and the other two did not coexist with other species. Cohabitation with infected dogs and the absence of house confinement restrictions in Vila Juerana make cats important carriers that spread tungiasis in this community. Chickens had a low frequency of tungiasis lesions despite living in proximity to infected dogs and cats.
Molecular Docking and Molecular Dynamics Simulations in Related to Leishmania donovani: An Update and Literature Review
Authors: Challapa-Mamani Mabel R. , Tomás-Alvarado Eduardo , Espinoza-Baigorria Angela , León-Figueroa Darwin A. , Sah Ranjit , Rodriguez-Morales Alfonso J. , Barboza Joshuan J.
Published: September 2023

Leishmaniasis, a disease caused by Leishmania parasites and transmitted via sandflies, presents in two main forms: cutaneous and visceral, the latter being more severe. With 0.7 to 1 million new cases each year, primarily in Brazil, diagnosing remains challenging due to diverse disease manifestations. Traditionally, the identification of Leishmania species is inferred from clinical and epidemiological data. Advances in disease management depend on technological progress and the improvement of parasite identification programs. Current treatments, despite the high incidence, show limited efficacy due to factors like cost, toxicity, and lengthy regimens causing poor adherence and resistance development. Diagnostic techniques have improved but a significant gap remains between scientific progress and application in endemic areas. Complete genomic sequence knowledge of Leishmania allows for the identification of therapeutic targets. With the aid of computational tools, testing, searching, and detecting affinity in molecular docking are optimized, and strategies that assess advantages among different options are developed. The review focuses on the use of molecular docking and molecular dynamics (MD) simulation for drug development. It also discusses the limitations and advancements of current treatments, emphasizing the importance of new techniques in improving disease management.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico
Authors: Ortega-Balleza Jessica , Guerrero Abraham , Castro-Escarpulli Graciela , Martínez-Vázquez Ana , Cruz-Hernández María , Luna-Santillana Erick , Acosta-Cruz Erika , Rodríguez-Sánchez Irám , Rivera Gildardo , Bocanegra-García Virgilio
Published: September 2023

The global spread of antimicrobial resistance genes (ARGs) is a major public health concern. Mobile genetic elements (MGEs) are the main drivers of this spread by horizontal gene transfer (HGT). Escherichia coli is widespread in various environments and serves as an indicator for monitoring antimicrobial resistance (AMR). Therefore, the objective of this work was to evaluate the whole genome of multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources. Four E. coli strains previously isolated from human urine (n = 2), retail meat (n = 1), and water from the Rio Grande River (n = 1) collected in northern Tamaulipas, Mexico, were analyzed. E. coli strains were evaluated for antimicrobial susceptibility, followed by whole genome sequencing and bioinformatic analysis. Several ARGs were detected, including blaCTX-M-15, blaOXA-1, blaTEM-1B, blaCMY-2, qnrB, catB3, sul2, and sul3. Additionally, plasmid replicons (IncFIA, IncFIB, IncFII, IncY, IncR, and Col) and intact prophages were also found. Insertion sequences (ISs) were structurally linked with resistance and virulence genes. Finally, these findings indicate that E. coli strains have a large repertoire of resistance determinants, highlighting a high pathogenic potential and the need to monitor them.
A Wheeler–DeWitt Non-Commutative Quantum Approach to the Branch-Cut Gravity
Authors: Bodmann Benno , Hadjimichef Dimiter , Hess Peter Otto , de Freitas Pacheco José , Weber Fridolin , Razeira Moisés , Degrazia Gervásio Annes , Marzola Marcelo , Vasconcellos César A. Zen
Published: September 2023

In this contribution, motivated by the quest to understand cosmic acceleration, based on the theory of Hořava–Lifshitz and on the branch-cut gravitation, we investigate the effects of non-commutativity of a mini-superspace of variables obeying the Poisson algebra on the structure of the branch-cut scale factor and on the acceleration of the Universe. We follow the guiding lines of a previous approach, which we complement to allow a symmetrical treatment of the Poisson algebraic variables and eliminate ambiguities in the ordering of quantum operators. On this line of investigation, we propose a phase-space transformation that generates a super-Hamiltonian, expressed in terms of new variables, which describes the behavior of a Wheeler–DeWitt wave function of the Universe within a non-commutative algebraic quantum gravity formulation. The formal structure of the super-Hamiltonian allows us to identify one of the new variables with a modified branch-cut quantum scale factor, which incorporates, as a result of the imposed variable transformations, in an underlying way, elements of the non-commutative algebra. Due to its structural character, this algebraic structure allows the identification of the other variable as the dual quantum counterpart of the modified branch-cut scale factor, with both quantities scanning reciprocal spaces. Using the iterative Range–Kutta–Fehlberg numerical analysis for solving differential equations, without resorting to computational approximations, we obtained numerical solutions, with the boundary conditions of the wave function of the Universe based on the Bekenstein criterion, which provides an upper limit for entropy. Our results indicate the acceleration of the early Universe in the context of the non-commutative branch-cut gravity formulation. These results have implications when confronted with information theory; so to accommodate gravitational effects close to the Planck scale, a formulation à la Heisenberg’s Generalized Uncertainty Principle in Quantum Mechanics involving the energy and entropy of the primordial Universe is proposed.
Correction: Lee, C.-P.; Chen, M.-R. Conquering the Nuclear Envelope Barriers by EBV Lytic Replication. Viruses 2021, 13, 702
Authors: Lee Chung-Pei , Chen Mei-Ru
Published: September 2023

In the original publication [...]
Securing the Future Railway System: Technology Forecast, Security Measures, and Research Demands
Authors: Unger Simon , Heinrich Markus , Scheuermann Dirk , Katzenbeisser Stefan , Schubert Max , Hagemann Leon , Iffländer Lukas
Published: September 2023

The railway industry—traditionally a conservative industry with low adaption speed for innovation—is currently entering its digitization phase. The sector faces a challenge in integrating new technologies and approaches into the employed—often safety-critical—systems. Keeping the systems secure while conforming to the demanding safety norms creates previously unknown problems. In the last decades, the number of attacks on the railway system has increased. Furthermore, with standardized digital technologies, the attack surface will keep growing. Therefore, in this work, we look into the foreseeable future of the railway system and present 21 likely use cases. We analyze these use cases regarding possible threats, rate the severity of these threats, and deduce and rate necessary countermeasures. To this end, we model these use cases and the corresponding threats and countermeasures using Attack Graphs. We use a graphical solution for the risk and security analysis due to advantages over other methods, i.e., table-based solutions, like simplified presentation and an easier understanding of relationships, dependencies, and interactions between various elements. From these Attack Graphs, we extracted 14 commonly recurring attack strategies. After analyzing 49 countermeasures regarding their current maturity and further research and standardization demands, we identified 21 in need of further investigation. This implies that 21 necessary countermeasures to secure these future use cases require further research to apply to railway systems or require standardization. These results will help researchers focus on the necessary research and standardization and railway operators to ensure the security of their systems.
Adaptive Individual-Level Cognitive Driving Anomaly Detection Model Exclusively Using BSMs
Authors: Wu Di , Tu Shuang Z. , Whalin Robert W. , Zhang Li
Published: September 2023

Detecting drivers’ cognitive states poses a substantial challenge. In this context, cognitive driving anomalies have generally been regarded as stochastic disturbances. To the best of the author’s knowledge, existing safety studies in the realm of human Driving Anomaly Detection (DAD) utilizing vehicle trajectories have predominantly been conducted at an aggregate level, relying on data aggregated from multiple drivers or vehicles. However, to gain a more nuanced understanding of driving behavior at the individual level, a more detailed and granular approach is essential. To bridge this gap, we developed a Data Anomaly Detection (DAD) model designed to assess a driver’s cognitive abnormal driving status at the individual level, relying solely on Basic Safety Message (BSM) data. Our DAD model comprises both online and offline components, each of which analyzes historical and real-time Basic Safety Messages (BSMs) sourced from connected vehicles (CVs). The training data for the DAD model consist of historical BSMs collected from a specific CV over the course of a month, while the testing data comprise real-time BSMs collected at the scene. By shifting our focus from aggregate-level analysis to individual-level analysis, we believe that the DAD model can significantly contribute to a more comprehensive comprehension of driving behavior. Furthermore, when combined with a Conflict Identification (CIM) model, the DAD model has the potential to enhance the effectiveness of Advanced Driver Assistance Systems (ADAS), particularly in terms of crash avoidance capabilities. It is important to note that this paper is part of our broader research initiative titled “Automatic Safety Diagnosis in the Connected Vehicle Environment”, which has received funding from the Southeastern Transportation Research, Innovation, Development, and Education Center.
European Inter-Laboratory Proficiency Test for Dourine Antibody Detection Using the Complement Fixation Test
Authors: Hébert Laurent , Froger Delphine , Madeline Anthony , Lecouturier Fanny , Lemans Charlène , Zientara Stephan
Published: September 2023

Dourine is a sexually transmitted parasitic disease affecting equids. Its causative agent is referred to as Trypanosoma equiperdum and the prescribed serodiagnosis method is the complement fixation test (CFT). In the context of our European Reference Laboratory mandate for equine diseases (excluding African horse sickness), we organised dourine CFT inter-laboratory proficiency tests (ILPTs) in 2015, 2018 and 2022 to evaluate the performance of the European Union network of National Reference Laboratories (NRLs) for dourine. ILPT panels were composed of horse sera with or without antibodies against Trypanosoma spp. originating from non-infected, immunised or experimentally infected horses. Twenty-two NRLs participated in at least one of the three sessions. In 2015, 2018 and 2022, the percentage of laboratories obtaining 100% of the expected results was 57, 90 and 80, respectively. These dourine CFT ILPTs showed the benefits of standardising the method’s detection limit and underlined the constant need to evaluate NRLs to improve the network’s performance. These results also argue in favour of the need for a representative bio-bank to improve the representativeness of ILPT samples and to allow the adoption of alternative serological methods for international surveillance of dourine.
Postoperative Computed Tomographic Assessment of the Complete Resection of an Infiltrative Lipoma Compressing the Spinal Cord in a Dog
Authors: Kim Junyoung , Kim Kitae , Oh Dayoung , Myung Hyunwook , Choi Jihye , Yoon Junghee
Published: September 2023

Infiltrative lipomas, which are locally invasive tumors composed of well-differentiated adipocytes, are histologically identical to lipomas but have a tendency to infiltrate adjacent muscle and fibrous tissue without metastasis, such as muscle; connective tissue; bone; and, in rare cases, peripheral nerves and the spinal cord. They differ from liposarcomas yet also exhibit neoplastic cell infiltration and often recur despite surgical removal. A 10-year-old spayed Maltese female dog presented with hindlimb paresis and back pain for two months. Computed tomography and magnetic resonance imaging revealed an extensive fatty mass impinging on the vertebral canal, compressing the spinal cord, and extending into the surrounding muscle layers and thoracic cavity. The mass was surgically removed, and subsequent postoperative computed tomography confirmed complete removal of the mass using Vitrea® advanced visualization fat measurement. Histopathological analysis confirmed that the mass was an infiltrative lipoma. The patient’s symptoms completely resolved after surgery, with no recurrence reported at the 2-year follow-up. This case highlights the benefits of using postoperative computed tomography combined with the automated fat measurement technique to determine whether reoperation is necessary or to predict patient prognosis by identifying potential residual lipoma post-surgery.
Research on Robust Control of Intelligent Vehicle Adaptive Cruise
Authors: Zhu Zhaoxin , Bei Shaoyi , Li Bo , Liu Guosi , Tang Haoran , Zhu Yunhai , Gao Chencheng
Published: September 2023

To improve the anti-interference and robustness of the adaptive cruise control system in car-following mode, this paper designs a robust controller for the automobile adaptive cruise control system which contains two layers, the upper and lower structures, based on the μ control theory. On the one hand, the upper controller calculates the theoretical safety distance between two automobiles based on the current working conditions, and it calculates the expected acceleration of the vehicle through an optimal control method based on the safety distance and two vehicle speeds. On the other hand, this paper constructs the lower μ integrated controller of an automobile longitudinal dynamics system based on the performance requirements of an adaptive cruise control system and solves it in Matlab. Then, through calculation and simulation, it demonstrates that the designed dual-layer LQR-μ controller has good performance robustness and robust stability, which can significantly improve the anti-interference ability and driving safety performance of the vehicle during the following cruise process.
Psychological defenses in patients with autonomic nervous system disorder
Authors:   FSBEI HE Petrozavodsk State University, Khyanikyainen I.V. , Rzheutskaya N.A. ,   FSBEI HE Petrozavodsk State University
Published: September 2023

In order to identify psychosocial characteristics of individuals with autonomic nervous system disorder (ANSD), 104 patients of the organized population of Petrozavodsk (n=104; mean age 36.8±10.7 years; gender index 1:1) were examined. The control group included healthy individuals (n=30; mean age 36.1±5.5 years; gender index 1:1; p=0.761). The ANSD diagnosis was confirmed by means of the Questionnaire for identifying signs of vegetative changes and the Study scheme for detecting signs of vegetative disorders (Vein A.M. et al., 2003), as well as by palpatory examination using the Markelov-Naryshkin method. The calculation of the Kerdo index in the patients with ANSD showed a predominance of sympathicotonia (40.38% and 50.0% of cases among men and women, respectively) over parasympathicotonia (21.15% of the patients without gender differences). In addition, psychological defenses (PD) were investigated using the method of the Life Style Index (LSI) (R. Plutchik, H. Kellerman, R. Conte, 1979). It was found that the patients with ANSD were characterized by an increase in the overall stress index of psychological defense mechanisms due to “regression” (22.28±15.45 (0) / 35.57±14.6 (9.33±5.31)), “projections” (23.97±17.61 (10.78±3.59) / 31.23±18.05 (12.83±6.11)), and “substitutions” (20.43±12.74 (5.65±1.15) / 16.29±10.85 (6.67±3.98)), with statistically rarer use of “denial” (36.71±15.42 (47.68±13.98) / 34.18±17.64 (51.8±14.37) percentiles among men with ANSD (healthy individuals) / women with ANSD (healthy individuals); p=0.001). Gender specificity was noted only in relation to the PD “reactive education”, with its predominant use by women 37.88±23.71 (compared with 23.27±19.37 percentiles in men; p<0.01). The identified psychosocial predictors are aimed at timely diagnosis and optimization of medical and psychological rehabilitation of patients with ANSD.
Vestibular schwannomas with neuroimaging signs of spontaneous regression: frequency of continued growth after surgery
Authors:   FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Kurnukhina M. Yu. , Brevdo A. M. ,   FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Cherebillo V. Yu. ,   FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Gavrilov G. V. ,   FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Ashryapova D. Sh. ,   FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Politova A. O. ,   FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia
Published: September 2023

Purpose. To determine the frequency of continued growth after surgical treatment in patients with neuroimaging signs of spontaneous regression of vestibular schwannoma. Material and methods. The study included 55 patients with histologically verified vestibular schwannoma. For a comparative assessment of the results of the study, 2 groups were formed: group I included 58.2 % of patients who had no signs of spontaneous regression (gender ratio — 1:4, more often — women), group II included 41.8 % of patients with the presence of one of the MR signs of regression (gender ratio was 1:1.3). The following parameters were analyzed as the studied MR characteristics: the presence of scalloped borders, the filling of the internal auditory canal with cerebrospinal fluid, and the heterogeneity of the accumulation of contrast agent by the tumor. The retrosigmoid access was used for the patients of the studied groups. Results. The patients with these neuroimaging parameters were characterized by a prolonged asymptomatic period which led to the diagnosis of vestibular schwannoma in the late stages — KOOS 4 (𝜒2=4.8; p<0.03). In the patients with MR characteristics of spontaneous regression with any size of vestibular schwannoma, a high frequency of continued growth after surgical treatment was revealed (p<0.05), which demonstrates the «aggressiveness» of the course of the disease. The results obtained indicate the need for increased oncological alertness in these patients. Conclusions. A detailed study of the MR characteristics of spontaneous regression of vestibular schwannomas can improve the patients’ quality of life and treatment outcomes.
Visceral obesity is a risk factor for the health of children and adolescents (literature review)
Authors:   FBSI «Novosibirsk Research Institute of Hygiene» of Rospotrebnadzor, Novosibirsk, Russian Federation, Novikova I. I. , Shevkun I. G. ,   Federal service of Rospotrebnadzor, Moscow, Russian Federation, Sorokina A. V. ,   FBSI «Novosibirsk Research Institute of Hygiene» of Rospotrebnadzor, Novosibirsk, Russian Federation, Romanenko S. P. ,   FBSI «Novosibirsk Research Institute of Hygiene» of Rospotrebnadzor, Novosibirsk, Russian Federation, Shepeleva O. A. ,   3FGBOU VO «Northern State Medical University» of the Ministry of Health of Russia, Arkhangelsk, Russian Federation, Gavrish S. M. ,   FBSI «Novosibirsk Research Institute of Hygiene» of Rospotrebnadzor, Novosibirsk, Russian Federation
Published: September 2023

The article presents the results of an analytical review of publications on the problem of visceral obesity in children and adolescents, which in recent years has been given increasing importance as a risk factor for the development of chronic non-infectious pathology due to the peculiarities of the etiology and pathogenesis of the formation of visceral obesity. The purpose of the study is to analyze Russian and foreign scientific publications devoted to the study of this problem. The analytical method of research is used in the work. About 200 literature sources have been worked out, 56 sources were used in the article, of which 20 are articles by foreign authors. The analytical review reflects the prevalence of visceral obesity. In the child and adolescent population, features of the etiology and pathogenesis of the formation of visceral obesity, its role in the development of the metabolic syndrome and its associated chronic non-infectious pathology. The data of studies characterizing the factors influencing the development of visceral obesity and methods for assessing adipose tissue, including those in children and adolescents, are presented.
The relationship between the birth rate and wages of the population in the regions of Russia in 2020-2022
Authors:   Federal Scientific Center of Hygiene named after F. F. Erisman» Rospotrebnadzor, Mytishchi, Russia, Pavlovskaya N.A.
Published: September 2023

The article conducted an analysis of the relationship of fertility and wages in the regions of the Russian Federation for 2020, 2021 and 2022. It is shown that a decrease in the birth rate in many regions led to an increase in the number of regions with low birth rate (5.8–7.9 people by 1000) by 3 times. It was established that with salaries from 15 to 50–60 thousand rublesшIn a month, the birth rate depended on the level of salaries. At the same time, the intensity of the salary contribution to the birth rate depended on the salary. The lower the salary was, the more intense the influence of its birth rate is intensively expressed. The most intensive effect on the decrease in the birth rate was observed with salaries of 15–20 thousand rubles/month. The lowest birth rate was noted in regions in which more than 19 % of the population received a salary of less than 15 thousand rubles/month. Currently, with salaries of more than 60 thousand rubles a month, the influence of the economic factor on the birth rate is small. The results can be used in the development of issues to improve the demographic situation in the Russian Federation.
Myocardial infarction and pregnancy
Authors:   FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov of the Ministry of Health of Russia, Klimov V. A.
Published: September 2023

The article presents an analysis of circulatory disorders in the coronary vessels during pregnancy, childbirth, and the postpartum period. In recent years, there has been a tendency towards an increase in the level of maternal mortality associated with cardiovascular diseases. There has been a rise in the incidence of myocardial infarction and acute coronary syndrome both during pregnancy and childbirth. These indicators are associated with physiological changes in the main parameters of hemodynamics and the hemostatic system at different stages of gestation, which often provokes or complicates the development of coronary heart disease. The main pathogenetic mechanisms responsible for the development of cardiac catastrophe, such as atherosclerosis, spontaneous dissection of the coronary arteries, coronary thrombosis, and vasospasm, are considered. Particular attention is paid to the characteristic features of the clinical picture and the importance of modern diagnostic methods in establishing an accurate diagnosis, including determining the level of troponin, pregnancy-associated plasma protein A, transthoracic and transesophageal echocardiography, and coronary angiography. The basic principles of managing pregnancy with coronary heart disease at different stages have been determined, including the choice of delivery method and management in the postpartum period. The issues of pharmacological therapy are considered, taking into account the possible negative impact on the health of the mother and fetus.
Some current aspects of regional rehabilitology
Authors:   Orenburg State Medical University, Kaspruk L. I. , Mikhailov S. N. ,   Orenburg State Medical University
Published: September 2023

In 2023, September 8 marks World Physical Therapy Day. Modern domestic trends in the development of a comprehensive rehabilitation system are bringing regional specialists not only to a new level of recognition and demand, but also to the need to create innovative approaches to the modern system of professional training. The narrative of combining a variety of restorative measures that have an effect on the patient, the emergence of statutory enactments regulating various areas of rehabilitation, as well as the approval of a new medical specialty “Physical and Rehabilitation Medicine” with the corresponding professional specialist standard prove the increasing relevance of comprehensive rehabilitation. The study presents a particularly significant function of medical personnel in the rehabilitation system and identifies regional features in the process of specialist training using the example of the Orenburg Region.
A patient with constipation
Authors:   SBHI RR Kerch City Children’s Hospital, Rybachok O. A.
Published: September 2023

Constipation is slow, difficult, or systematically insufficient bowel movement (bowel voiding). The World Health Organization in the “International Statistical Classification of Diseases and Related Health Problems. ICD-10” classifies constipation as a disease (code K59.0). Meanwhile, gastroenterology organizations such as the World Gastroenterology Organization and the American Gastroenterological Association take a different position, emphasizing that constipation is not a disease, but a symptom. Leading Russian gastroenterologists share the same position.
Understanding the patient’s experience of coeliac disease diagnosis: a qualitative interview study
Authors: Harper Alice M , Watson Jessica , O’Donnell Rachel , Elwenspoek Martha MC , Banks Jonathan
Published: September 2023

Background

Coeliac disease (CD) presents with non-specific symptoms, and delays to diagnosis are common. The traditional diagnostic pathway involves serological testing followed by endoscopic biopsy; however, the evidence is increasing about the effectiveness of a diagnosis without the need for a biopsy.

Aim

To understand the patient’s experience of being diagnosed with CD.

Design and setting

A qualitative study was conducted, which involved semi-structured interviews with adults diagnosed with CD living in the UK.

Method

Participants (n= 20) were purposefully sampled from 200 adults who had completed a diagnostic confidence survey. Interviews were conducted via video-conferencing software (Zoom), recorded, and transcribed verbatim. Data were analysed using reflexive thematic analysis.

Results

Interviewees faced pre-diagnostic uncertainty, presenting with non-specific symptoms that many experienced for several years and may have normalised. GPs often attributed their symptoms to alternative diagnoses, commonly, irritable bowel syndrome or anaemia. Investigations caused further uncertainty, with half of the interviewees unaware that their initial serology included a test for CD, and reporting long waits for endoscopy and challenges managing their diet around the procedure. Their uncertainty reduced once they received their biopsy results. Endoscopy was presented as the ‘gold standard’ for diagnosis and most interviewees believed that the procedure was necessary for diagnostic confidence and conviction in a lifelong gluten-free diet.

Conclusion

Patients experience uncertainty on the pathway to a diagnosis of CD. GPs could improve their experiences by being mindful of the possibility of CD and sharing information about serological testing. Policy and guidance should address the time to endoscopy and diet during diagnosis. If diagnosis without biopsy is adopted, then consideration should be given to clinical pathway implementation and communication approaches to reduce patient uncertainty.
Zum Einfluss karolingischer Sammeltätigkeit auf die Überlieferung spätantiker Bibeldichtungen
Authors: Kreuz Gottfried Eugen
Published: September 2023

Un nombre anormalement élevé de poèmes bibliques de l’Antiquité tardive, ont été transmis comme Pseudépigraphes, et les noms des auteurs auxquels ils ont été attribués semblent suivre un modèle étrange, étant donné qu’ils se réfèrent rarement à des poètes, mais presque toujours aux premiers prosateurs chrétiens. Depuis Reinhart Herzog, qui a publié quelques considérations préliminaires sur les causes de ce phénomène dans son livre essentiel sur la poésie biblique en 1975, aucune enquête supplémentaire n’ a été entreprise. L’étude présentée ici tente (1) de montrer quels critères ont été déterminants pour la compilation de «corpus scolaires » à l’époque carolingienne, et quelle influence ce processus a eu sur les noms des auteurs attribués à ces poèmes ; (2) de donner des exemples de l’évolution de quelques-uns de ces «corpus scolaires » , à savoir celui contenu dans le manuscrit Paris, BNF, lat. 13047, et le corpus exégétique compilé par le prêtre Wigbod pour l’Ancien et le Nouveau Testament.
À propos d’un manuscrit de Nicolò Leonico Tomeo, le modèle de l’édition princeps du Lapidaire orphique
Authors: Cariou Morgane
Published: September 2023

Numerous links exist between manuscripts that belonged to the Paduan philosopher Nicola Leonico Tomeo and the editions published by Aldus Manutius and his heirs. This article investigates the case of MS Paris, BNF, Greek 2764. As is demonstrated by discreet markings made with dry point, MS 2764 provided the copy-text for the edition of the Orphic Lithica published by Gian Francesco d’Asola in 1517. It was also used for the first edition of Colluthus, prepared by Aldus Manutius in 1504. Contrary to what might be thought on the basis of both marginal branches and a dedication to a woman named Fosca, MS 2764 was not copied by Tomeo. Tomeo was only the owner and annotator of the MS. It was, in fact, written by a copyist belonging to Tomeo’s circle who imitated his master’s marginalia in order to pay tribute to him. Three copies of the Orphic Lithica produced around that time by Zacharias Callierges enable us to identify the scribe’s circle. Further analysis of MS 2764 shows that the marginalia so far ascribed to Tomeo were in fact quite common in his circle. Two appendices to the article aim at offering a glimpse of Tomeo’s rich library. The first one lists and describes 12 manuscripts (now in the BnF) that were copied by Tomeo. It also tries to identify three different writing styles and to differentiate the folios that were copied by Tomeo himself from those that were written by collaborators using a very similar style of writing. The second appendix lists 16 manuscripts (also preserved in the BnF) that were annotated by Tomeo.
As contribuições da arte na educação especial como ferramenta pedagógica lúdica e inclusiva
Authors: Cintra Rosana Carla Gonçalves Gomes , Brum Ana Paula Vaz
Published: September 2023

O artigo investiga a contribuição da arte como ferramenta pedagógica lúdica na Educação Especial, para a inclusão das crianças com deficiência na educação infantil. Como base teórica, utilizamos as contribuições de Vygotsky na psicologia histórico-cultural. O problema de pesquisa é: qual a relevância da arte como ferramenta pedagógica, facilitadora de aprendizagem e inclusão na educação infantil? A fim de encontrar encaminhamentos, organizamos nossos procedimentos metodológicos por pesquisas em documentos, periódicos, livros, dissertações e teses e, análise do questionário intitulado “Inquérito para professores do Brasil que atuam na educação infantil e possuem crianças inclusas”, respondido por 21 profissionais da educação infantil do estado de Mato Grosso do Sul na cidade de Campo Grande. Como resultado, percebeu-se que a arte facilita a aprendizagem, o acolhimento das diferenças, o desenvolvimento das especificidades, promovendo inclusão.
Fuerza del suelo pélvico postparto tras un programa de rehabilitación
Authors: Gallegos Ana Sofía Guzmán , Díaz Mónica Hernández , Centeno Elizabeth Orduña , Sánchez Daniela Natalia Solís , Vargas María Eustolia Pedroza , Morales Ángel Salvador Xeque , Hernández Arely Guadalupe Morales
Published: September 2023

Introducción: El suelo pélvico (SP) es un conjunto de estructuras que se encargan de soportar a los órganos que resguardan y dan estabilidad mientras se realizan actividades, como estar de pie o realizar movimientos, así como mantener la continencia.  Gracias a los tejidos blandos presentes en el SP, se tienen cualidades físicas que ayudan en su función, por ejemplo, la resistencia, contractibilidad, flexibilidad y la fuerza. Es así, como la fuerza muscular está encargada de mejorar la ejecución de acciones motoras que permiten la continencia urinaria y fecal, también favorece el control postural, contribuyendo en el patrón respiratorio y el complejo abdomino-lumbo-pélvico. El parto es un evento en el cuál todo el complejo abdomino-lumbo-pélvico se ve alterado, principalmente la pérdida de la estabilidad pélvica y a su vez la pérdida de la fuerza muscular. El postparto es un periodo que comienza a partir del alumbramiento y que continúa a través del tiempo, clasificándose en postparto inmediato, precoz y tardío. Un programa de rehabilitación es un conjunto de ejercicios enfocados a un mismo fin, dirigido hacia al SP resulta altamente beneficioso para la mejora de la calidad de vida de la mujer, la vuelta a su condición pre-gestacional y a modificar cualquier alteración músculo-esquelética desarrollada en el embarazo, parto o preexistente a la gestación. Objetivo: Determinar la fuerza del suelo pélvico postparto antes y después de un programa de rehabilitación. Método: Se revisaron 33 expedientes clínicos, de pacientes de la clínica Fisio Ser, pertenecientes a mujeres primíparas de entre 18 y 45 años que hubieran pasado el alumbramiento a partir de la semana 36 de gestación, por parto no instrumentado, de los cuales se obtuvieron datos acerca de la valoración del suelo pélvico por medio del protocolo P.E.R.F.ECT, con la finalidad de comparar la variabilidad de la fuerza tras un periodo de rehabilitación fisioterapéutica de dos meses. Resultados: De los expedientes revisados, la edad P50=32 (rango: 25-41 años), el 100% de las participantes mostró cambios significativos en la fuerza resultando en una media de 3.7 y DE final de 1.1. Conclusión: El ejercicio terapéutico en mujeres postparto es eficaz y la comparación de la fuerza en el suelo pélvico tras la rehabilitación muestra una ganancia significativa (0.000 Wilcoxon Signed Ranks Tes).
Social Entrepreneurship in the UAE: An Exploration of Undergraduates' Attitudes, Motivations and Intentions
Authors: Hamouda Angela , Wood Bronwyn
Published: September 2023

This exploratory study examines the attitudes towards social entrepreneurship amongst a group of students in an early cohort mandated by the government to undertake entrepreneurship education. As such, the study collects responses from students across a range of disciplines, focusing on their interpretation of the impact and importance of the education they have received and how it relates to (and motivates) them to pursue entrepreneurship, and social entrepreneurship in particular, themselves. As a ‘first step’, this initial study highlights areas which should be examined in detail through qualitative methods and suggests early indications for elements which would be useful in a framework to support policy and community interest in social entrepreneurship endeavours.
Toward Universal Creativity Assessment by Untrained Judges
Authors: Batal Thibaut
Published: September 2023

The purpose of a creativity session being first to generate many ideas, how to fast and reliably assess each one’s creativity, even with non-creativity experts? Creative people appearing not only to be good at generating ideas but also at implicitly evaluating them, improving people’s assessment would further improve their own creativity. This paper investigates canonical components of originality to identify universal creative performance subscales assessable by untrained judges. Three originality criteria emerged from theoretical research: (1) Feelings, emotions; (2) Imagination, fantasy; (3) Logical complexity. One criterion was used to assess appropriateness: (4) Consistency as defined by four rules. A corpus of 100 ideas were distributed for assessments by untrained judges (n=41). All ideas were assessed by 4 expert judges on a single criterion: creativity. Surprisingly the criterion (4), which had four clear rules to define it, showed insufficient reliability and had to be disregarded for the analysis. The three other criteria proved consistent with one another and were hence reduced to an assessment of originality. They showed poor consistency with expert judges’ ratings. These results are discussed and call for further research to better understand creativity.
A Literature Review and Emerging Trends on Key Topics of Risks and Challenges Facing Tourism Real Estate Investments
Authors: Anastasopoulos Ioannis , Varelas Sotirios
Published: September 2023

Tourism real estate entrepreneurs and general real estate investments face a multitude of risks and challenges that can impact their success. These risks can stem from economic, environmental, and political factors. Economical risks such as inflation and recession can affect the demand for real estate investments. Environmental risks such as natural disasters or climate change can lead to damage to the property and the desirability of the location. Political risks such as changes in regulations or geopolitical tensions can also affect the success of the investment. This paper conducts a literature review in order to mitigate these risks for entrepreneurs and real estate investors before making investment decision. This paper includes analyzing the local market, understanding the demographic trends, and identifying potential challenges that may arise. Moreover, the implementation of risk management strategies and the existence of a contingency plan can contribute to the stability and sustainability of this type of investment with a focus on real estate, especially tourism real estate. Further research and analysis are needed to better understand the impacts of technological advancements on the real estate industry. Advancements such as virtual reality and blockchain technology have the potential to revolutionize the industry, but there is still much to learn about how they will affect the market. Additionally, the impacts of climate change on the real estate industry need to be further explored. As extreme weather events become more frequent, it is important to understand how this will impact the desirability of certain locations and the potential for property damage. In conclusion, the risks and challenges facing tourism real estate entrepreneurs and general real estate investments are numerous and varied. It is essential for investors to conduct thorough research and analysis before making any investment decisions and to implement risk management strategies to protect against unexpected events.
Realization of Entrepreneurial Intentions in Global Crises: A Qualitative Study
Authors: Neff Alexander , Würthner Tanja , Weber Patrick , Werth Daniel
Published: September 2023

Managers have at least two social roles in their job position: One is to keep the business running while the other role searches for entrepreneurial opportunities to exploit. Both roles have one aspect in common: the security of the organization’s existence, in short term as manager and in long term as entrepreneur. Our paper compares entrepreneurial intentions - the mental preparation to follow entrepreneurial goals – as well as the realization of these intentions in crises. The research question is: how do global crises affect the realization of entrepreneurial intentions? The approach is explorative, describes four directions of entrepreneurial intentions and what happened during their realization. We conducted two qualitative interview series, partly structured with two sequentially partly standardized guidelines, one in 2018/19 with 13 participants, the follow-up series in 2022/23 with 10 of the 13. The intentions of the interviews from 2018/19 were assigned to four directions: four of the wholesaling managers intended no to low collaboration in the familiar markets (direction I), four sought high collaboration in the familiar markets (II), two wanted no to low collaboration but to engage in unfamiliar markets (III), and three were looking for high collaboration in unfamiliar markets (IV). During the second interview series we confronted the participants with their intentions. The responses of 2022/23 show that global crises influenced the entrepreneurial intentions in different ways. Despite several crises between the two interview series, three wholesalers followed their intentions. All others changed directions. While some managers struggled with the situation and postponed or even discarded the intentions others saw new opportunities and exploited them. Consequently, it can be stated that crises can nevertheless maintain intentions and/or lead to new ideas. In times of a crisis, it is advisable to continue to keep both roles: the manager role must guide the company through the crisis, while at the same time ensuring its existence by exploiting opportunities as entrepreneur. For this purpose, we derived entrepreneurial paths from the results: (1) focus on existing business in familiar market, (2) expansion of the business segment in familiar market, (3) entering unfamiliar markets.