Terpenes effect on lipidogram parameters in patients with metabolic syndrome (pilot data)
Authors:   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Doskina E.V. ,   Archimed V Clinic of New Medical Technologies LLC, Moscow, Russian Federation, Maganova F.I. ,   Initium-Pharm LLC, Moscow, Russian Federation, Bibova O.A. ,   Initium-Pharm LLC, Moscow, Russian Federation, Zakirova A.M. ,   Kazan State Medical University, Kazan, Russian Federation,   Central City Clinical Hospital No. 18 named after K.Sh. Zyiatdinov, Kazan, Russian Federation, Kashapov L.R. ,   Kazan Federal University, Kazan, Russian Federation,   BIOMED Diagnostic and Treatment Center LCC, Kazan, Russian Federation, Osmanova V.M. ,   PreventMed" LLC, St. Petersburg, Russian Federation, Rashitova E.L. ,   Dmitry Rogachev National Medical Research Center for Children's Hematology, Oncology and Immunology, Moscow, Russian Federation
Published: November 2024

Background: metabolic syndrome (MS) is a precursor to atherosclerosis, type 2 diabetes mellitus, and cardiovascular complications, highlighting the critical need for timely intervention in emerging disorders.
Aim: this study aims to assess the efficacy of the terpene-containing biologically active dietary supplement CardioOrganik® (Initium-Pharm,
Russia) in patients diagnosed with MS.
Patients and Methods: an outpatient study was conducted involving 31 patients with MS, including 20 women (54%), aged between 45 to
76 years (mean age 54±6 years). Patients had not previously taken hypolipidemic medications prior to their inclusion in the study. Clinical
assessments included evaluation of patient complaints, general clinical parameters, blood lipid profile, serum glucose levels, and homocysteine
levels (n=21). Additional measurements included blood pressure, body weight, heart rate, and both echocardiographic and electrocardiographic
examinations. Following the baseline assessment, patients were advised to take 1 capsule of the biologically active dietary supplement three
times daily, 20 minutes before meals, over a period of 3 months. A follow-up assessment was carried out subsequently.
Results: initial assessments identified elevated total cholesterol levels in 25 patients. Following the 3-month intervention, reductions in
cholesterol were observed in all patients, with 7 patients (28%) achieving normalized levels. Reductions in triglycerides and low-density lipoproteins (LDL) were observed across all participants, while high-density lipoproteins (HDL) increased in 100% of patients without
surpassing reference levels. At baseline, normal homocysteine levels (5–15 mmol/l) were present in only 2 patients (9.52%). Post-therapy, 19 patients demonstrated normalization of homocysteine levels. Fasting glucose levels decreased from 7.8±0.81 to 7.38±0.76 mmol/l after 3 months. All patients exhibited weight loss during the study period.
Conclusion: the terpene-containing biologically active dietary supplement CardioOrganik ® demonstrated efficacy in addressing dyslipidemia and normalizing homocysteine levels, supporting its recommendation as a component of preventive treatment tactics in
patients with metabolic syndrome.
KEYWORDS: terpens, lipidogram, metabolic syndrome, homocysteine, dyslipidemia.
FOR CITATION: Doskina E.V., Maganova F.I., Bibova O.A., Zakirova A.M., Kashapov L.R., Osmanova V.M., Rashitova E.L. Terpenes effect on lipidogram parameters in patients with metabolic syndrome (pilot data). Russian Medical Inquiry. 2024;8(9):537–543 (in Russ.). DOI: 10.32364/2587-6821-2024-8-9-6