bluuebunny/crossref_metadata_2025 huggingface dataset:
Neighborhood deprivation in relation to lung cancer in individuals with type 2 diabetes—A nationwide cohort study (2005–2018)
Authors: Li Xinjun , Jansåker Filip , Sundquist Jan , Crump Casey , Hamano Tsuyoshi , Sundquist Kristina
Published: July 2023

Background

Neighborhood deprivation has been found associated with both type 2 diabetes and lung cancer. The aim of this study was to examine the potential association between neighborhood deprivation and lung cancer incidence or mortality in individuals diagnosed with type 2 diabetes. The results may identify a new risk or prognostic factor for lung cancer in this important subgroup and help develop a more contextual approach to prevention that includes neighborhood environment.

Methods and findings

The study population included adults (n = 613,650) aged ≥ 30 years with type 2 diabetes during 2005 to 2018 in Sweden. Cox regression was used to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) for incidence or mortality of lung cancer associated with neighborhood deprivation. All models were conducted in both men and women and adjusted for individual-level characteristics (e.g. age, smoking- and alcohol-related comorbidities, sociodemographic factors). The cumulative incidence and mortality for lung cancer were 1.08% (95% CI, 1.06 to 1.11) and 0.93% (0.90 to 0.95), respectively, in the study population during the study period. Neighborhood deprivation was associated with both incidence and mortality of lung cancer in patients with type 2 diabetes independently of the individual-level characteristics. In the fully adjusted models, comparing high- with low-deprivation neighborhoods, the HRs for lung cancer incidence were 1.21 (1.10 to 1.33) in men and 1.08 (0.95 to 1.21) in women. The corresponding HRs for lung cancer mortality were 1.04 (1.00 to 1.07) in men and 0.97 (0.94 to 1.00) in women. Competing risk analyses including cardiovascular mortality attenuated the results.

Conclusion

In this large cohort of individuals with type 2 diabetes, we found higher lung cancer incidence and mortality in patients living in areas with high neighborhood deprivation, even after adjusting for individual-level characteristics. These findings may help develop a more contextual approach that includes the neighborhood environment when allocating resources for disease prevention and care in patients with type 2 diabetes. These findings could also help inform clinical care for patients with type 2 diabetes, particularly those living in deprived neighborhoods.
A scoping review protocol on diagnostic strategies to detect occult malignancies in individuals with ischemic stroke
Authors: Leentjens Jenneke , Chornenki Nicholas L. J. , Spiegelenberg Janneke , Ly Valentina , Dowlatshahi Dariush , Siegal Deborah M.
Published: July 2023

Background

Emerging data show an increased risk of ischemic stroke in patients with a new diagnosis of cancer. As the risk of stroke begins to increase 150 days before cancer is diagnosed, stroke may be the first clinical manifestation of undiagnosed cancer. About 6% of patients with cryptogenic ischemic stroke (unknown etiology after diagnostic evaluations) are diagnosed with cancer within one year. However, the optimal cancer screening strategy in this population is not known. We aim to conduct a scoping review of screening strategies for occult cancer in individuals with ischemic stroke.

Methods

Electronic databases including MEDLINE (Ovid), EMBASE (Ovid), CINAHL (EBSCOhost) and Scopus will be systematically searched to identify articles that report on screening strategies for occult cancer in individuals with ischemic stroke. At least two investigators will independently perform two-stage study selection consisting of title/abstract screening and full-text review, followed by data extraction. Thereafter, a thematic analysis will be conducted to provide an overview of what diagnostic tests/strategies have been used, and their clinical utility in terms of positive and negative predictive value (when available).

Conclusion

We anticipate that the findings of this scoping review will identify strategies used to detect occult cancer in individuals with ischemic stroke and summarize their clinical utility (if reported). Addressing this knowledge gap will help guide the development of future clinical trials on occult cancer screening patients with ischemic stroke.
Investigation of anti-proliferative and anti-angiogenic properties of Parkia javanica bark and fruit extracts in zebrafish
Authors: Dhakal Rasik , Kalladka Krithika , Singha Achinta , Pandyanda Nanjappa Dechamma , Ravindra Jeshma , Vittal Rajeshwari , Sil Samir Kumar , Chakraborty Anirban , Chakraborty Gunimala
Published: July 2023

The use of herbal products as traditional medicines has been a practice in India for centuries. Due to high ethnic diversity, the pool of herbal medicines is enormous, and they are often preferred over modern medicines in certain parts of the country. Cancer is one of the major non-communicable diseases affecting people worldwide. Despite considerable research, cancer is a disease that is still not understood completely, and there have been constant efforts towards the identification of novel drugs or approaches in cancer management. Parkia javanica, an important medicinal plant and a rich source of flavonoids and terpenoids, is widely studied for its antioxidant and anti-inflammatory activities. Traditionally, the fruit and bark extracts of P. javanica find use as home remedy for dysentery and piles in NE India. Moreover, the fruits are consumed by the people of North-East (NE) India as vegetables, either in steamed or cooked form. In this study, crude extracts of P. javanica fruit and bark were obtained, the sub-lethal dose was determined and were then analyzed for anti-proliferative and anti-angiogenic properties using a battery of assays in zebrafish embryos. The sub-lethal concentration 50 (LC50) was found to be 28.66 mg/L and 346.66 mg/L for bark and fruit extract respectively, indicating a decreased toxicity of the fruit extract compared to that of the bark. The anti-proliferative and anti-angiogenic properties were more pronounced for the fruit extract compared to the bark extract. Although preliminary, the results of the study suggest that P. javanica fruits possess potent anti-angiogenic and anti-proliferative properties, which can be further studied for the isolation of active phytochemicals for use as therapeutic agents.
UNCERTAINTIES IN CLIMATE CHANGE SCENARIOS FOR DETERMINING TEMPERATURE AND RAINFALL PATTERNS IN REGIONS WITH MIXED CLIMATE CONDITIONS
Authors:   Department of Soil and Water Engineering, PAU, Ludhiana, 141004, India, Aggarwal Rajan , Kaur Samanpreet ,   Department of Soil and Water Engineering, PAU, Ludhiana, 141004, India, U Din Dar Mehraj ,   Department of Soil and Water Engineering, PAU, Ludhiana, 141004, India, Kuriqi Alban ,   CERIS, Instituto Superior Tecnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal
Published: July 2023

Aim of the study: This study aims to quantify uncertainty in climate change impact assessment on crop production by using all available climate models (GCMs) under both harsh and mild emission scenarios from 2020 to 2095, which has not yet been done in the study region. Material and methods: In this regard, a comparative study was carried out for Ludhiana district, Punjab, India, in which Global Climate Model (GCM) outputs for daily maximum (Tmax) and minimum temperature (Tmin) and rainfall under A1B scenario concerning Mid Century (MC) (2020-2050) and End Century (EC) (2070-2095) was extracted from ECHam5-GCM and PRECIS model. DSSAT v.4.6.1 model and Papadakis method were used to study the climate change behavior under these two-time slices. In addition, climate data from RCP scenarios for the future were extracted from five randomly selected GCMs under scenarios RCP 4.5 and RCP 8.5 using the marksim DSSAT weather generator. Results and conclusions: The results showed that the annual minimum temperature would increase by 2.4 °C and 2.45 °C during EC using ECHAM5 and PRECIS models. In contrast, under RCPs 4.5 and 8.5 scenarios, the mean annual temperature would increase by 1.56°C in MC and 3.11°C in EC compared to that of the baseline period and 2.75°C in MC and 5.46°C in EC compared to that of the baseline period, respectively. The corresponding likely decrease in annual RF under RCP 4.5 is 98 mm and 90 mm during MC and EC, respectively. The corresponding increase in annual RF under RCP 8.5 is 153 mm and 251 mm, respectively.
The use of data mining methods to identify risks of fetal pathology
Authors:   Bryansk State Technical University, Leonov Yury , Filippova Lyudmila ,   Bryansk State Technical University, Martynenko Aleksey ,   Bryansk State Technical University, Sviridova Elvira ,   Bryansk State Technical University
Published: July 2023

Reducing child mortality is reflected in several United Nations Sustainable Development Goals and is a key indicator of human progress. The use of information technology makes it possible to process a large number of generated statistical data, or to form new ones over time based on the results of analyses and examinations of a huge number of patients, use the results to determine deviations in the early stages and identify the influence of certain indicators on the likelihood of pathologies. Based on the analysis, the functional requirements for the system are formulated and the task of developing a new information and analytical system is set. The article is devoted to the actual problem of determining the risks of fetal pathology during pregnancy. A variant of the classification of the presence of fetal abnormalities using multinomial logistic regression and a method for clustering patient risk groups using the k -means method was proposed, an optimization technique based on the Broyden - Fletcher - Goldfarb - Shanno method was applied, where memory (L-BFGS) was used as a limitation, the classification of fetal health occurs according to the specified three classes. An information system has been developed to visualize the results of analytical methods. When creating the software package, the client - server architecture was used, which allows the server device to support multi-user mode and provide simultaneous work with several clients. The system includes: an application for Windows, an application for Android. Server interaction module, database interaction module, data analysis module, patient data processing module, doctor data processing module, module, statistical sampling module, personal data protection module, rights differentiation module, visualization module. The modular architecture allows you to upgrade the system, add new modules as needed and make changes to the modules while maintaining the integrity of the system. The developed system has passed the stages of testing and performance evaluation.
Modeling of the library collection acquisition process
Authors:   Orenburg State University, Dusakaeva Slushash , Bolodurina Irina ,   Orenburg State University
Published: July 2023

Сonstantly increasing assortment of literature of various genres and directions offered by publishers sets a problem for the libraries when purchasing new literature in the conditions of limited budgeting. In this connection, the task of the qualitative acquisition of the library stock is urgent. The main conceptual idea for the solution of the problem is the maximum satisfaction of the information needs of various types of library resource users. To implement the users informational preferences, a general mathematical model of decision-making support has been developed in the task of optimizing library stock acquisition. It allows it to be replenished and renewed in order to meet the information needs of library resource users and takes into account the limited budgeting for acquiring new books. The demand for library resources is considered as the optimality criterion. A formalized approach to the process of completing the library fund with popular printed publications is proposed. To reduce the area dimension of possible solutions, a model approximation of the optimization problem has been constructed. The transition from the optimization problem to its model approximation is based on the ideas of identifying the most important features of the area of possible values and the segmentation of the readership. In the practical implementation of the constructed model, the method of data mining, the method of analyzing strategic alternatives and the theory of fuzzy sets in accordance with the specifics of the problem to be solved were used in determining each significant classification problem. The model, constructed and tested on the basis of the scientific library of the Orenburg State University (OSU), allows to take into account not only the influence of various factors on the quality of the library stock, but also the issues caused by the limited budgeting of libraries.
Application of the random dichotomous classification method to assessment builder’s brand based on consumer’s reviews
Authors:   Perm National Research Polytechnic University, Minin Anton , Fedoseev Sergey ,   Perm National Research Polytechnic University
Published: July 2023

The brand influences the success and sustainability of the builder. In this paper, the authors continue to address the problem of managing developer branding based on information on the Internet. The paper proposes a dichotomous classification that allows you to classify developer reviews based on randomly labeled data. he dichotomous classification method allows you to work with small databases, in contrast to methods based on the construction of artificial neural networks, which require large samples of data. The method was implemented in the "Eidos" system. The Eidos system is based on automated system cognitive analysis (ASC-analysis). The decision to change the recall marker was made on the basis of changing the credibility of the model by Van Riesbergen's F-measure. The application of the dichotomous classification method to classify developers' reviews was tested on the example of OJSC "Perm Silicate Panels Plant" (PZSP). The dichotomous classification method allowed us to distinguish 20 negative and 63 positive reviews in the collected sample. The performance and adequacy of the method used is shown. In particular, it is shown that it is possible to divide the collected textual information about the developer into two clusters without prior training. The dichotomous classification method reduces the developer's response time to a reference. This paper proposes an algorithm for reference clustering based on the dichotomous classification method. This algorithm can be used as a basis for software to collect and analyze developer data, as well as to manage developer branding.
A REORGANIZAÇÃO DO CONVÍVIO FAMILIAR COM CRIANÇAS EM PANDEMIA PELA COVID-19 NO BRASIL
Authors: SOMMERHALDER ALINE , ZANOTTO LUANA , PENTINI ANNA ALUFFI
Published: July 2023

RESUMO: Este artigo objetiva discutir o convívio doméstico cotidiano de famílias com crianças em idade escolar diante da pandemia de COVID-19. Intenciona, ainda, problematizar possíveis mudanças na rotina de vida de crianças brasileiras, em decorrência da ausência de frequência presencial nas escolas e ampliação de tempo diário em contextos domésticos. O trato crítico-interpretativo ofertado aos dados pauta-se nas concepções de convívio familiar, em consonância com o pensamento teórico sócio-humanista. Com aplicação de método misto (quantitativo e qualitativo), apresenta parte de resultados brasileiros obtidos por meio de questionário on-line, e-survey, em formato de opinião pública. Participaram 478 famílias brasileiras, majoritariamente residentes em municípios do estado de São Paulo. Os resultados indicam que a estruturação familiar acompanha mudanças propostas pelos adultos como sujeitos protagonistas de um saber fazer no cotidiano doméstico transformado pela pandemia. À luz da dialogia freireana, as mudanças indicadas pelos adultos ocorreram pela ampliação do sentimento de proximidade e reconhecimento dos filhos, além da inserção na rotina das atividades escolares e recriação de novas formas de educação diante dos diversos limites impostos. As alterações ocorridas na esfera domiciliar perpassam pela compreensão de novas configurações que estabeleçam relações educativo-dialógico-cooperativa entre os diferentes membros, crianças e adultos.
LEITURA ANTES E DEPOIS DA APOSENTADORIA: REPRESENTAÇÕES SOCIAIS E PRÁTICAS DE PROFESSORAS
Authors: OLIVEIRA NETO ANTÔNIO DURÃES DE , VELOSO GEISA MAGELA
Published: July 2023

RESUMO: Este artigo tem o objetivo de discutir a constituição das práticas e representações sociais de leitura de professoras aposentadas, mapeando os processos e as funções do ler antes e depois da aposentadoria. Para isso, realizou-se uma pesquisa qualitativa com participação de 55 docentes. Na revisão de literatura, lançou-se mão dos estudos de Batista (1998); Britto (1998); Corsino (2010); Guareschi (1995); Moscovici (1978; 2015); Zilberman (1999). Constatou-se, à luz dos estudos de Serge Moscovici (1978) acerca da Teoria das Representações Sociais, que, no decurso das trajetórias vividas, ocorreram mudanças relacionadas à finalidade das práticas leitoras. Na infância e adolescência, as representações sociais de leitura foram construídas no contexto da ausência de livros e leituras, e nas atitudes vinculadas ao incentivo e à prática, direcionadas à família e à escola. Na fase adulta, antes da aposentadoria, a leitura tinha um caráter obrigatório, vista como fundamental para a atuação docente em sala de aula. Depois de se aposentarem, as práticas de leitura das professoras ganham novos contornos e passam a ser realizadas a partir de seus interesses pessoais, ou seja, leem o que querem e quando querem, sem terem consigo a imposição de realizarem leituras para atender a uma necessidade profissional.
CONCEPTUAL AND PEDAGOGICAL DIFFERENCES BETWEEN THE TERMS “BRINCADEIRA” AND “GAME” IN BRAZIL
Authors: MELLO MARIA APARECIDA
Published: July 2023

ABSTRACT: This article is part of a thesis produced for a competitive examination for the full professor position. Its objective was to identify the theoretical differences between the concepts of “brincadeira”1 and “game,” the role of each one in children’s learning, and its implications in pedagogical practices in Early Childhood Education. The Cultural-Historical Theory was the basis for the theoretical research through the genetic method in the methodology from a bibliographic survey in books and scientific articles about “brincadeira” and “game,” and in Russian authors only about “game.” The results pointed out the importance of the differentiation between both terms in Early Childhood Education, as well as enabled the proposition that “brincadeira” is the main activity of children from 0 to 3 years old, and “game,” especially “role-play,” as the main activity of children from three to six years old. The importance of these results for children’s learning corroborates the centrality of the playful aspect in the activities of Early Childhood Education, distinguishing “brincadeira” and games in their contents, motives, needs, and specificities for children. This proposal to change the main activity in Early Childhood Education also indicates the need for “brincadeira” from 0 to 3 years old to develop into role-play games for children from 3 to 6 years old since both are essential for children’s activities to also change from involuntary to voluntary and volitional activities. The implications of this research for teaching practices are centered on the need for teachers to know and include role-play games in the activities of 3 to 6-year-old children, helping them develop autonomy, volitional activities, and self-control of their attitudes.
O refluxo gastroesofágico e a relação mãe e bebê: estudo de caso
Authors: Zacara Deborah Juliana dos Santos , Miranda Monica Carolina , Barros Izabella Paiva Monteiro de
Published: July 2023

Resumo O presente artigo problematiza aspectos afetivos inerentes à relação materno-filial que podem estar associados ao surgimento e estabelecimento de sintomas psicossomáticos de refluxo gastroesofágico no bebê de até 1 ano de idade. Para tanto, apresenta-se estudo de caso de uma díade mãe-bebê auxiliado por entrevista semiestruturada, aplicação das pranchas 1, 2 e 7MF do teste de apercepção temática e observação naturalista. Cada instrumento foi analisado qualitativamente e teve seus resultados integrados e articulados à teoria psicanalítica. Os principais resultados apontaram certa fragilidade egóica e necessidade de apoio social por parte da mãe, compatíveis com o período do puerpério. São discutidas possíveis maneiras de funcionamento do psiquismo materno, por exemplo, quando sobrecarregado com afetos ansiosos, há sobredeterminação de sintomas psicofuncionais no bebê, os quais, por sua vez, causam efeitos no modo como a mãe se posiciona no exercício da maternagem suficientemente boa, marcando um interjogo relacional.
Elaboration and implementation of a protocol for the Golden Hour of premature newborns using an Implementation Science lens
Authors: Silva Elizangela Sant’Anna da , Primo Cândida Caniçali , Gimbel Sarah , Almeida Márcia Valéria de Souza , Oliveira Norma Suely , Lima Eliane de Fátima Almeida
Published: July 2023

Objective: describe the process of designing and implementing a care protocol for the first hour of life of premature newborns. Method: a participatory research study using an implementation science framework, the Consolidated Framework for Implementation Research (CFIR) was employed to determine drivers and facilitators of implementation success of the Golden Hour protocol for newborns at a large university hospital in southeastern Brazil. A multi-professional team, including first line providers and managers participated in six stages of quality improvement: situational diagnosis; protocol elaboration; training protocol implementation; barrier and facilitator assessment; and protocol monitoring and review. Qualitative and monitoring data collected across these six stages were analyzed using descriptive statistics and content analysis. Results: the institution’s Golden Hour protocol was organized by the multi-professional team based on a collective and dialogical approach. The protocol prioritized the infant’s cardiopulmonary stability, as well as prevention of hypothermia, hypoglycemia and infection. After four months of implementation, the care team was evaluated the protocol as a good quality intervention, necessary for the service, low-cost and not very complex. One suggested improvement recommended was to carry out refresher training to address staff turnover. Conclusion: implementation of the Golden Hour protocol introduced an appropriate and feasible neonatal care quality improvement process, which requires periodic refresher training to ensure greater adherence and better neonatal results.
Elaboração e implementação de protocolo para Hora Ouro do recém-nascido prematuro utilizando ciência da implementação
Authors: Silva Elizangela Sant’Anna da , Primo Cândida Caniçali , Gimbel Sarah , Almeida Márcia Valéria de Souza , Oliveira Norma Suely , Lima Eliane de Fátima Almeida
Published: July 2023

Objetivo: descrever o processo de elaboração e implementação de protocolo assistencial para a primeira hora de vida do recém-nascido prematuro. Método: pesquisa participativa, que utilizou referencial da ciência da implementação e os domínios do Consolidated Framework for Implementation Research. Estudo realizado em hospital universitário no sudeste do Brasil, com participação da equipe multiprofissional e gestores. O estudo foi organizado em seis etapas, por meio do ciclo de melhoria contínua (Plan, Do, Check, Act): diagnóstico situacional; elaboração do protocolo; treinamentos; implementação do protocolo; levantamento de barreiras e facilitadores; monitoramento e revisão do protocolo. Os dados foram analisados por estatística descritiva e análise de conteúdo. Resultados: o primeiro protocolo Hora Ouro da instituição foi organizado pela equipe multiprofissional a partir de uma abordagem coletiva e dialógica. O protocolo priorizou a estabilidade cardiorrespiratória, prevenção de hipotermia, de hipoglicemia e de infecção. Após treinamento e implementação por quatro meses, o protocolo foi avaliado como uma intervenção de qualidade, necessária ao serviço, de baixo custo e pouco complexa. A principal sugestão de melhoria foi realizar ações educativas frequentes. Conclusão: a implementação provocou mudanças e iniciou um processo de melhoria da qualidade da assistência neonatal, sendo necessária a manutenção dos treinamentos para maior adesão e melhores resultados.
Distrés psicológico en estudiantes de enfermería: relación con tiempo de pantalla, dieta y actividad física
Authors: Ramón-Arbués Enrique , Granada-López José Manuel , Satústegui-Dordá Pedro José , Echániz-Serrano Emmanuel , Sagarra-Romero Lucía , Antón-Solanas Isabel
Published: July 2023

Objetivo: determinar la prevalencia de síntomas de ansiedad y depresión, al igual que su asociación con el tiempo de pantalla, la dieta y la actividad física, en una cohorte de estudiantes de enfermería. Método: estudio descriptivo y transversal sobre una muestra de 648 estudiantes de enfermería. Se utilizaron la Hospital Anxiety and Depression Scale, la versión corta del International Physical Activity Questionnaire y el Índice de Alimentación Saludable español. Se llevaron a cabo diferentes modelos de regresión lineal múltiple para analizar la asociación entre los síntomas de ansiedad y depresión, y el tiempo de pantalla, la dieta y la actividad física. Resultados: la prevalencia de síntomas de ansiedad y depresión fue de 24,1% y 3,7%, respectivamente. El tiempo de pantalla prolongado (>6 horas por día), baja actividad física y dieta inadecuada se asociaron de manera independiente y significativa con una mayor sintomatología psicológica. Conclusión: la salud mental de los estudiantes de enfermería podría beneficiarse de implementarse iniciativas que promuevan estilos de vida saludables.
Derrubar para edificar: presenças e ausências raciais e de gênero no Museu de Arte Contemporânea do Ceará
Authors: Marcondes Guilherme
Published: July 2023

Resumo Compreendendo os museus como espaços de preservação, divulgação e construção da memória, o acervo do Museu de Arte Contemporânea do Ceará (MAC/CE) foi tomado para análise. O objetivo da pesquisa era entender quem eram os(as/es) artistas cujas produções estéticas compunham o acervo da instituição em termos raciais e de gênero. A pesquisa entrecruzou, então, a sociologia da arte com a sociologia das relações étnico-raciais e a sociologia do gênero, com especial enfoque nas teorias feministas negras, tendo como questão de trabalho, portanto, a pergunta: qual o papel da racialidade e do gênero no processo de legitimação de artistas no campo da arte contemporânea brasileira? Este artigo descreve o processo de pesquisa e seus resultados (que incluem uma exposição realizada no MAC/CE), apresentando as ausências e presenças no acervo em questão. Apesar do senso comum tomar o universo das artes visuais como um espaço de liberdade, cujas regras seriam menos rígidas e discriminatórias, a pesquisa, que contou também com a aplicação de questionário com artistas do acervo, indica que os padrões estabelecidos na sociedade envolvente também se fazem presentes no mundo da arte.
Research on Integrated Resorts (IR) and the Tourism Strategy Choice of Singapore
Authors:   The Korea International Trade Research Institute, Kim Jee-Seon
Published: July 2023

Purpose – The purpose of this study is to trace the process by which Singapore considered and reached social consensus on the development of integrated resorts (IR), including casinos. Additionally, this study aims to derive policy implications as a systemic basis for future IR development in Japan. Design/Methodology/Approach – A meta-analysis was conducted to analyze the context and content of policy decisions in detail, focusing on the theoretical discussion of the characteristics of Singaporean IR, and the political and social decision-making process surrounding the introduction of the IR business. Findings – The Singaporean government demonstrated an inclusive policy decision-making process that convinced various stakeholders, especially civil society and the religious community, on the introduction of casinos. In addition, to minimize the social side effects of introducing casinos, the government actively provided safety measures, and pursued a strategy to lead investors to invest a large amount of money in Singapore’s tourism infrastructure along with license renewal negotiations. Research Implications – By analyzing the policy compliance process of citizens and the effective use of policy framing regarding politically and socially controversial IR business, this study helps to understand the policy decision-making process concerning IR. Furthermore, through the successful case of Singapore, this study can provide a framework that can be applied systematically for future IR business development in Japan.
Ehnolinguistic features of family rituals of Transcarpatians in M. Dochinets’s “Indents and treasures” collection
Authors:   National University of Uzhhorod, Uzhhorod, Ukraine, PYSKACH Оlha
Published: July 2023

The paper examines the reproduction peculiarities of action, real-object and verbal elements of family rituals in the context of artistic style; the specifics of the artistic representation of the family rituals of Transcarpathians in connection with the personality of M. Dochynets himself as an implicit narrator has been traced; semantic and word-forming and etymological analysis of ceremonial names has been carried out as well. The family rituals of Transcarpathians are artistically reproduced in the short stories “Circus”, “Ant in Amber”, “Domestic Bird” (birth ceremony); “Black Angel”, “Wax Rings” (funeral rite); “Mother’s Bread” (wedding ceremony). Family rituals in M. Dochynets’s works are represented both through artistic images and the prism of philosophical, traditional folk and religious ideas of the author himself as an implicit narrator. The picture of his artistic world reproduces the peculiarities of the national Ukrainian worldview and world consideration. Action elements of family rites are most vividly reproduced, including washing and dressing of the deceased, night vigil near the deceased, wedding invitations, gift giving to the young, etc. In most of them, pagan and Christian traditions are closely intertwined, fixed in the mental consciousness of Transcarpathians. The specificity of the real-object plan of family rites in M. Dochynets’s novel is the reflection of mystical, symbolic features formed on the basis of mythical and religious ideas of the people. The verbal context of the family rituals of the analyzed collection is represented mainly by lexemes and occasionally by phrasemes. By origin, these are mostly Ukrainian proper names with Proto-Slavic roots and a few borrowings. Most of the ceremonial nominations are the words of Ukrainian origin used mostly in the literary language, with the exception of a few dialectical words (sváyba, krúzhmo, uprovíd, dérevúsche). Symbolic meaning is inherent in such names as soul, candle, cross, wax rings, etc.
Verbalization of the red colour mythologem in Oleksii Dovhiy’s poetry
Authors:   Taras Shevchenko national University of Kyiv, STROKAL Oleksandr
Published: July 2023

The peculiarities of the linguistic expression of the mythologem “red” on the material of Oleksii Dovhiy’s poetic texts are analyzed in the study. The author of the article characterized the grammatical, semantic, stylistic, individual-author’s characteristics of using the language units denoting the realities associated with the considered mythologem. During the research, the author made a number of theoretical generalizations about the role of linguistic means in the process of representing the poet’s creative idea, features of the worldview of his lyrical hero. The article clarifies the role and functions of poetic text in the authorreader dialogue. The researcher analyzed a number of scientific statements concerning the peculiarities of interaction of individuals’ linguistic worldview within a certain collective, and found that ethnic-regional peculiarities, local traditions, customs and rituals affect the individual’s psycholinguistic paradigm. The researcher based his point of view on the issue of linguistic understanding of the concepts of myth, mythologem and mythema. The article emphasizes the special function of linguistic units that denote the realities associated with the color red in Oleksii Dovhiy’s poetic texts. The analyzed units were grouped according to their grammatical characteristics, structure and semantics. The author of the article found out that words denoting the mythologem of the color red and the realities associated with it participate in the creation of a number of author’s images and motifs in the analyzed poetic texts, which significantly expand the boundaries of the semantic content of this mythologeme. During the research, it was found that in numerous authorial contexts, the mythologem of the color red is associated with images of the ideal locus, changes, transformations, revolutions and wars, as well as with the feeling of love and female beauty. The author of the article noted that verbalizers of the ideal locus are often associated with images of the sun in the lyrical hero’s mind; the words, which indicate to the changes are often associated with images of fire, wounds and blood; words, which in the lyrical hero’s mind are associated with love and female beauty, contain in their composition semantic indications of different types of shades of red.
New dictionary of linguistics terminology. Publication Review: Ukrainian-English-Lithuanian-Polish-Greek-Latin Dictionary of Linguistic Terminology
Authors:   Institute of the Lithuanian Language, Vilnius, Republic of Lithuania, GRITĖNIENĖ Аurelija
Published: July 2023

Publication Review: Ukrainian-English-Lithuanian-Polish-Greek-Latin Dictionary of Linguistic Terminology / edited by О. Nika, S. Hrytsenko. Sumy: Universytetska knyha, 2022. 220 p.
Кассационное производство по уголовному делу: проблемы производства в суде кассационной инстанции по уголовному делу
Authors: Кузнецова В.А.
Published: July 2023

Статья рассматривает процедуру кассационного производства по уголовному делу в России. Авторы анализирует основные проблемы, связанные с этой процедурой, такие как ограничения, накладываемые изменением закона, и необходимость установления существенных ошибок в приговоре. Также обсуждаются изменения в законодательстве России, которые влияют на процедуру кассации. В статье представлены требования, которые необходимо соблюдать при проведении кассационного производства по уголовному делу.
Metabolic therapy in the rehabilitation of children with the consequences of perinatal hypoxia
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Goncharova O.V. , Mashkovtseva E.V. ,   Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Nartsissov Y.R. ,   Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russian Federation,   Biomedical Research Group, BiDi Pharma GmbH, Siek, Germany
Published: July 2023

Perinatal hypoxia is a common cause of developmental delays, disorders of the nervous and cardiovascular systems, and immune disorders. Early comprehensive rehabilitation of children with hypoxic lesions to the central nervous system can alleviate pathological manifestations and normalize the process of development. This review discusses different aspects of metabolic therapy for the rehabilitation of such children and describes the results of some studies assessing the efficacy of Glycine and Biotredin in children with various disorders. The combination of these two drugs proved to be effective in premature infants of various gestational age through normalizing their neurological status and improving weight and growth parameters. The article also describes the principles of metabolic correction of speech disorders in the critical preschool period, as well the mechanisms underlying the effect of the drugs on the cellular metabolism of the nervous system. Key words: hypoxia, metabolic therapy, preterm birth, glycine, speech disorders
Challenges in the diagnosis and treatment of acute respiratory infections in children during the tridemic
Authors:   Kazan State Medical Academy, branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation, Safina A.I. , Vyzhlova E.N. ,   N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russian Federation, Malinovskaya V.V. ,   N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russian Federation
Published: July 2023

This article describes cases of acute respiratory viral infections in children during the tridemic characterized by simultaneous circulation of various strains of influenza virus, respiratory syncytial virus, and SARS-CoV-2 viruses. The differential diagnosis based on clinical manifestations alone is extremely challenging, while laboratory methods for rapid pathogen identification are lacking. This dictates the need to revise antiviral therapy tactics. The new approach implies the inclusion of interferon alpha-2b with antioxidants that have a wide range of antiviral activity. Early initiation of treatment with interferon alpha-2b prior to pathogen identification ensures good therapeutic results. High frequency of mixed infections and risk of complications in children with functional and morphofunctional abnormalities necessitates higher doses of interferon alpha-2b and longer treatment, particularly in patients with severe infections (influenza, COVID-19, or their combination). Key words: influenza, ARVI, COVID-19, tridemic, children, interferon, antioxidants
Side effects of lidocaine in outpatient pediatrics
Authors:   N.F.Filatov Children’s City Clinical Hospital No 5, Saint Petersburg, Russian Federation, Udaltsov M.A. , Pshenisnov K.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian, Aleksandrovich Yu.S. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian, Kaziakhmedov V.A. ,   N.F.Filatov Children’s City Clinical Hospital No 5, Saint Petersburg, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian, Esikov V.V. ,   N.F.Filatov Children’s City Clinical Hospital No 5, Saint Petersburg, Russian Federation, Aleksandrovich I.V. ,   I.I.Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation
Published: July 2023

Lidocaine poisoning with parenteral administration, accompanied by systemic toxic effects, is quite rare in pediatric practice, but even single cases may cause the development of critical conditions that require treatment in the intensive care unit. Objective. To demonstrate a clinical case of severe lidocaine poisoning in two children and the main measures to stabilize the condition of patients with overdoses of local anesthetics. The article presents the basic historical data on the creation of lidocaine, its pharmacokinetics and pharmacodynamics in children. The maximum single dose was indicated based on the patient's weight. The main principles of intensive therapy for lidocaine poisoning in children were considered, and the algorithm of actions in the development of a life-threatening state was provided. Special attention was paid to the use of the «lipid rescue protocol» in hemodynamic disorders and cardiac arrest. Conclusion. When prescribing local anesthetics in children, one should take into account the anatomical and physiological characteristics of the child, the age characteristics of the pharmacological effects of the drugs, and the maximum permissible single dose, which will prevent the occurrence of iatrogenic life-threatening complications. Key words: lidocaine, poisoning, systemic toxic effects, intensive care, pediatric
Saccharomyces boulardii CNCM I-745 and acute intestinal infections: new data and an old problem
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Belmer S.V.
Published: July 2023

Acute intestinal infections (AIIs) have always been a significant problem in all age groups, particularly in children under 5 years of age. AIIs are characterized by high incidence and can result in severe or even life-threatening dehydration. Therefore, rehydration is the first and compulsory component of the treatment in these patients. In addition to oral rehydration, probiotics are crucial for AII treatment. Probiotics are live microorganisms that can improve the health of the host when prescribed in adequate doses. Multiple microorganisms with probiotic activity have been isolated so far. Saccharomyces boulardii, a probiotic yeast, has a special place among all probiotics. One of its strains, S. boulardii CNCM I-745, has demonstrated its high probiotic activity and safety in numerous randomized clinical trials and confirmed by meta-analyses. In particular, in a randomized controlled trial SABINA conducted in Argentina, S. boulardii CNCM I-745 showed higher efficacy than Bacillus clausii in reducing the duration of acute diarrhea in children. In 2023, the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) provided updated recommendations for the use of probiotics for the management of AIIs. Among other things, it states that S. boulardii CNCM I-745 can be recommended for the management of acute gastroenteritis in children, since there is evidence of reduced duration of diarrhea. Thus, isolation of S. boulardii CNCM I-745 provided new treatment options for a wide range of diseases, including AIIs. Key words: acute intestinal infections, acute gastroenteritis, acute enteritis, probiotics, S.boulardii CNCM I-745, treatment, children, recommendations, Enterol
KEDUDUKAN HUKUM PEMEGANG SAHAM YANG TIDAK MELAKUKAN PENYETORAN MODAL SECARA PENUH ATAS PEMBAGIAN DIVIDEN DALAM PERSEROAN TERBATAS
Authors: Nata Indra Jaya
Published: July 2023

This article aims to find out about the legal standing of shareholders who do not make a full capital deposit on dividend distribution in a limited liability company. This legal research is a normative legal research and the legal source used consists of primary legal material and secondary legal material, then analyzed by deductive method of silogism based on the mindset of the general to specific things, by connecting between the major premise and the minor premise is further drawn conclusively. The results of this legal research show that the legal standing of shareholders who do not make a full capital deposit causes the loss of shareholders' rights in accordance with Article 52 paragraph (1) of the UUPT including the right to obtain dividend distribution. Such rights will be obtained by shareholders after carrying out their obligations to deposit capital in full.
KAJIAN YURIDIS PRAKTIK PERSEKONGKOLAN DALAM TENDER (Studi Putusan KPPU Perkara Nomor 24/KPPU-I/2016)
Authors: Az Zarah Intania
Published: July 2023

This research aims to determine the consideration of a conspiracy in the Commission decision on Case No. 24 / KPPU-I / 2016 and implementation of legal justice in the Commission’s Decision Case No. 24 / KPPU-I / 2016 in terms of economic and fairness aspects. This research is a normative law research which are prescriptive and applied. The approach used are the statute approach and the case approach. The sources of legal materials consist of primary legal materials, secondary and tertiary legal materials with literature study. This research used deductive analysis technique. Commission’s in Decision Number 24 / KPPU-I / 2016 has considered on the case in accordance with Law No. 5 of 1999, however its considerations do not consider whether the consequences of the conspiracy are hindering business competition or not. The commission in deciding the Commission Case Number 24 / KPPU-I / 2016 tended to only pay attention to the justice aspect  while the economic aspect seemed a little neglected, so that the KPPU Decision Number 24 / KPPU-I / 2016 did not fully fulfill legal justice.

Keywords: Tender Conspiracy; Business Competition; Fairness
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Authors: Sun Yifei , Zhang Yihan , Zhang Jifeng , Chen Y. Eugene , Jin Jian-Ping , Zhang Kezhong , Mou Hongmei , Liang Xiubin , Xu Jie
Published: July 2023

Background :
sodium-dependent glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2, respectively. SGLT-2 is almost exclusively expressed in the renal proximal convoluted tubule cells. SGLT-1 is expressed in the kidneys but also in other organs throughout the body. Many SGLT inhibitor drugs have been developed based on the mechanism of blocking glucose (re)absorption mediated by SGLT1/2, and several have gained major regulatory agencies’ approval for treating diabetes. Intriguingly these drugs are also effective in treating diseases beyond diabetes, for example heart failure and chronic kidney disease. We recently discovered that SGLT-1 is upregulated in the airway epithelial cells derived from patients of cystic fibrosis (CF), a devastating genetic disease affecting greater than 70,000 worldwide.
Results:
in the present work, we show that the SGLT-1 upregulation is coupled with elevated endoplasmic reticulum (ER) stress response, indicated by activation of the primary ER stress senor inositol-requiring protein 1a(IRE1a) and the ER stress-induced transcription factor X-box binding protein 1 (XBP1), in CF epithelial cells, and in epithelial cells of other stress conditions. Through biochemistry experiments, we demonstrated that XBP1 acts as a transcription factor for SLC5A1 by directly binding to its promoter region. Targeting this ER stress ® SLC5A1 axis by either the ER stress inhibitor Rapamycin or the SGLT-1 inhibitor Sotagliflozin was effective in attenuating the ER stress response and reducing the SGLT-1 levels in these cellular model systems.
Conclusions:
the present work establishes a causal relationship between ER stress and SGLT-1 upregulation and provides a mechanistic explanation why SGLT inhibitor drugs benefit diseases beyond diabetes.
Measurements of the Corpus Callosum in epileptic patients Using Magnetic Resonance Imaging
Authors: Sharifi Yasaman , Rahimian Elham , Rafaati Ali , Tafakhori Abbas
Published: July 2023

Background and Purpose:
In recent years, magnetic resonance imaging (MRI) has been used to evaluate seizures in patients with epilepsy. The Corpus callosum (CC) serves as a crucial communication structure between the two brain hemispheres, making it valuable to study MRI changes in patients with epilepsy. This study aimed to measure the CC in patients with epilepsy and report any structural differences.
Materials and Methods:
We conducted a cross-sectional study involving 150 patients diagnosed with epilepsy. T2W MRI mid-sagittal cuts were taken to measure the length and width of the middle third of the CC.
Results:
The mean length of the CC was 6.89 ± 0.59 cm, while the mean width of the middle third of the CC was 3.23 ± 1.3 mm. Significant correlations were found between CC measurements and factors such as the number of drugs used, drug resistance, refractory epilepsy (RE), and the presence of MRI lesions.
Conclusion:
The results demonstrate that epilepsy affects the CC, and there is likely a correlation between CC width, the number of drugs used, drug resistance, and the presence of primary lesions in MRI. These findings can contribute to further studies on prognostic factors in epilepsy.