bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of full-waveform inversion to land data: Case studies in onshore Mexico
Authors: Reta-Tang Cristina , Sheng James , Liu Faqi , Cantú Alfredo Vázquez , Vargas Alejandro Cabrales
Published: March 2023

Velocity model building and imaging for land surveys are often challenging due to near-surface complexity contaminating the reflection signal. Incorporating full-waveform inversion (FWI) in the velocity model building workflow for land surveys offers benefits not achieved with traditional model building tools, but it also brings difficulties. We have developed an effective model building workflow for land seismic data that incorporates dynamic matching FWI (DMFWI). DMFWI employs an objective function that uses multidimensional local windowed crosscorrelations between the dynamically matched version of observed and synthetic data. Dynamic matching de-emphasizes the impact of amplitudes, allowing the algorithm to focus on using kinematic information for velocity updates. The proposed workflow produces a geologically plausible and consistent model for data acquired with limited offsets. Refraction and reflection tomography may also be included in the workflow. The workflow is applied to onshore surveys in Mexico. Despite challenges of the near-surface geology and limitations of the acquisition parameters in the study areas, the proposed model building workflow successfully derives a high-resolution velocity model that significantly improves the migrated depth image.
Seismic Soundoff: Why you need the Gravity and Magnetic Encyclopedic Dictionary
Authors: Geary Andrew
Published: March 2023

Serguei Goussev discusses his new book, Gravity and Magnetic Encyclopedic Dictionary. Goussev describes his motivation for compiling the resource, the unique format he created, a few of his favorite terms, and what he hopes the book will achieve.
A Roundtable on Environmental Injustice and Border Abolition
Authors: Cohen Ilana , Crow-Willard Emma , Dutta Gupta Tanaya , Hammami Jamila , Jozef Guerline , Sacco Steven , Shull Kristina , Walker Angela V. , Wane Aly , Watman Daniel , Wheatley Christine
Published: March 2023

This article posits border abolition as a radical alternative to the Anthropocene. It convenes a group of eleven activists, organizers, scholars, practitioners, educators, and storytellers to discuss their work building cross-border solidarities along the US-Mexico border and in US immigration detention, Puerto Rico, Ghana, and the Bengal Delta. Participants provide critical analysis of the origins of environmental injustice and border violence and discuss how a confluence of ecological crisis, environmental racism, and border militarization since the 1980s disproportionately impacts BIPOC and queer/trans communities and exacerbates migrant precarity and displacement worldwide. Participants share ways they have built alternatives to border and ecological violence through migrant accompaniment, legal and policy advocacy, divestment activism, storytelling, education, and sustainability projects. The discussion is organized around three key themes: environmental injustice, racism, and borders; strategies adopted by organizers to build environmental and migrant justice; and visions of border abolition.
ISG20L1 acts as a co-activator of DAPK1 in the activation of the p53-dependent cell death pathway
Authors: Zou Shuxian , Zhang Chongchong , Xu Huan , Liu Zhihui , Hu Yongliang , Wang Wei , Liu Kun , Wen Qing , Song Lun
Published: March 2023

Our previous studies have revealed that GADD45α is a liable proapoptotic protein, which undergoes MDM2-dependent constitutive ubiquitylation and degradation in resting cancer cells. Under chemotherapeutic agent (such as arsenite, 5-Fu and VP-16) exposure, DAPK1 functions as a novel p53 (also known as TP53) kinase, which induces phosphorylation of p53 at Ser15 and transactivates the p53 target Ets-1, to synergistically repress IKKβ-dependent MDM2 stability, and ultimately removes the inhibitory effect of MDM2 on GADD45α, resulting in GADD45α accumulation and cell apoptosis. In the current study, we show that there is a strong induction of ISG20L1 (also known as AEN) expression in several cancer cell lines under exposure of arsenite and other chemotherapeutic agents. Surprisingly, although originally identified as a transcriptional target of p53, ISG20L1 induction was not controlled by p53. Instead, ISG20L1 functioned as upstream activator of p53 by interacting with DAPK1, and plays an essential role in promoting DAPK1–p53 complex formation and the subsequent activation of Ets-1/IKKβ/MDM2/GADD45α cascade. Therefore, our findings have revealed novel function of ISG20L1 in mediating cancer cell apoptosis induced by chemotherapeutic agents via modulating activation of the DAPK1- and p53-dependent cell death pathway.
Από το «απελευθερωτικό επαναστατικό πρόταγμα» στην αλλοτρίωση μέσω του ολοκληρωτικού γραφειοκρατικού κράτους
Authors: Δρίτσας Γιώργος
Published: March 2023

Ο 19ος αιώνας αποτέλεσε έναν αιώνα πολυποίκιλων μεταβολών και ανακατατάξεων. Το παλιό Ancien Régime είχε ήδη ξεκινήσει να ακολουθεί μία καθοδική πορεία σε όλες τις χώρες της Ευρώπης. Ταυτόχρονα νέα έθνη-κράτη αναφάνηκαν και μαζί τους νέες πολιτικές κατευθύνσεις και παραγωγικές σχέσεις. Ο αιώνας που επέφερε την άνθιση του Διαφωτισμού στο πεδίο των ιδεών και του Καπιταλισμού στο πεδίο της οικονομίας ήταν πλέον εδώ. Ο φιλόσοφος Karl Marx, προσπαθώντας να ερμηνεύσει το νέο φαινόμενο, όπως τουλάχιστον αυτό διαμορφώθηκε στη χώρα του τη Γερμανία, κατέληξε στην πεποίθηση ότι η τεχνική εξέλιξη και η πρόοδος μέσω της Βιομηχανικής Επανάστασης είχαν παρακωλυθεί, μέσα στον νέο αστικό κόσμο που είχε τότε αναδυθεί. Αργότερα το έργο του και οι απόψεις του αυτές θα τύγχαναν πολλών και διαφορετικών ερμηνειών, καθώς και παρερμηνεύσεων —ειδικά κατά τον 20ο αιώνα. Παρακάτω, στηριζόμενοι στις παρατηρήσεις του Κώστα Παπαϊωάννου πάνω στο ζήτημα αυτό, θα προσπαθήσουμε να δώσουμε απαντήσεις στην παραπάνω προβληματική και να σκιαγραφήσουμε τις προκύψασες φιλοσοφικές αντιδόσεις μεταξύ «δασκάλου» και «μαθητών».
Η πολιτική διάσταση της αρχαίας τραγωδίας στον Κώστα Παπαϊωάννου και τον Κορνήλιο Καστοριάδη
Authors: Σχισμένος Αλέξανδρος
Published: March 2023

Η σκέψη του Κ. Παπαϊωάννου γύρω από την ιστορία και την επαναστατική δραστηριότητα των μαζών υπήρξε πρωτότυπη και σημαντική, εντοπίζοντας ιστορικές συνδέσεις και συσχετισμούς που παρέμεναν ασαφείς για τον σύγχρονο στοχασμό. Μία από τις πιο σημαντικές για εμάς σήμερα θέσεις του αφορά τη σχέση μεταξύ της αρχαίας ελληνικής πολιτικής και της κλασικής αττικής δραματουργίας και την ανάδυση της αρχαίας αθηναϊκής δημοκρατίας ως «Θεατροκρατίας». Τον προβληματισμό του Παπαϊωάννου φαίνεται να συμμερίζεται ο έτερος διάσημος συνεπιβάτης του Ματαρόα, ο Κορνήλιος Καστοριάδης, που επίσης αναδεικνύει την πολιτική διάσταση της αρχαίας τραγωδίας ως κύριο θεσμό αυτοπεριορισμού της δημοκρατίας και κριτικού αναστοχασμού της πόλεως. Θα αναζητήσω συνοπτικά ομοιότητες και διαφορές των προσεγγίσεων του Παπαϊωάννου και του Καστοριάδη στην αττική τραγωδία, με στόχο να τεθεί εκ νέου ο προβληματισμός γύρω από τον πολιτισμό, το ήθος και τον τραγικό χαρακτήρα του δημοκρατικού διακυβεύματος.
Effectiveness of a Disease Management Program (DMP) in controlling the progression of Chronic Kidney Disease among hypertensives and diabetics.
Authors: Sequira Leena , Prabhu A. Ravindra , S Mayya Shreemathi , Prasad Nagaraju Shankar , S Nayak Baby
Published: March 2023

Background: In India, the number of patients with type II diabetes mellitus in 2006 was 40.9 million and is expected to increase by 2025 to 69.9 million. The occurrence rate of stage 5 CKD was 151 per million population in India.

Diabetes Mellitus and hypertension were the usual triggers of Chronic Kidney Disease (CKD). A structured education program helps in the prevention of diabetes and hypertension related complications. 

Methods: This quasi-experimental study was conducted among 88 participants who had hypertension, diabetes mellitus, or both for five or more years with an objective to find the effect of a Disease Management Program on delaying progression of CKD in patients with hypertension or diabetes mellitus. 

 The baseline data were collected on demographic proforma, serum creatinine, blood pressure, and random blood sugar, and the patients were taught the management of hypertension and diabetes mellitus. In the fourth and the eighth month, blood pressure and blood sugar were reassessed. At one-year blood pressure, blood sugar, and serum creatinine were tested. Baseline and one-year follow-up blood pressure, blood sugar, and estimated Glomerular Filtration Rate were compared. Descriptive statistics and "Wilcoxon signed-rank test" were used to analyze the data.  

 Results: In one year, the mean systolic blood pressure reduced by six mm of Hg and mean blood sugar by 24 mg/dl. The prevalence of CKD stage three and above (< 60 ml/min/m2) was nine (10.22%). The median decline in eGFR was 5 ml/min/m2 (Z= 5.925, P< 0.001). 

Conclusion: The Disease Management Program led to improvements in blood pressure and diabetes control and median progression of CKD was estimated at five ml/min/m2/year.
Phytochemicals, proximate composition, minerals and volatile oil analysis of Zanthoxylum acanthopodium DC. fruits
Authors: Satria Denny , Dalimunthe Aminah , Pertiwi Dewi , Muhammad Mahatir , Kaban Vera Estefania , Nasri Nasri , Waruwu Syukur Berkat
Published: March 2023

Background: The use of herbal plants is adopted as a traditional medicine because of their minimal side effects. Most plants have bioactive ingredients and nutritional content that can potentially be used as treatments. One plant that has the potential to be a source of modern medicine is Zanthoxylum acanthopodium DC. Historically the use of traditional medicine as a treatment has enjoyed a good sense of trust among the public. The purpose of this study was to perform a qualitative phytochemical screening and proximate analysis of samples of Zanthoxylum acanthopodium DC.

Methods: Used in this study were the phytochemical screening test using the thin-layer chromatography method and the proximate analysis using the AOAC method, which included measuring the ash, water, carbohydrate, total fat, protein, and crude fiber content of the samples. Hydrodistillation was used to isolate volatile oil from the sample, which was then identified using gas chromatography-mass spectrometry. The research method used is experimental.

Results: From the test, it was found that the phytochemical content of Zanthoxylum acanthopodium DC is alkaloids, flavonoids, tannins, saponins, glycosides, steroids, and triterpenoids. Proximate analysis obtained ash content of 6.19%, water content of 6.35%, carbohydrates of 35.4%, total fat of 2.46%, protein of 16.2%, and crude fiber of 33.4%. Mineral test results prove that Zanthoxylum acanthopodium DC contains Pb (<0.07 mg/Kg), Cd (<0.03 mg/Kg), As (<0.03 mg/Kg), Hg (0.0011 mg/Kg), Mn (43.1 mg/Kg), K (321 mg/Kg), Ca (0.22 mg/Kg), Mg (198 mg/Kg), Fe (52.1 mg/Kg), and Na (23.6 mg/Kg). The highest content of essential oil in Zanthoxylum acanthopodium DC is geranyl acetate, with a concentration of 24.26%.

Conclusions: This study concludes that the research findings of Zanthoxylum acanthopodium DC indicate that the phytochemical, mineral, and volatile oil content of the sample is strongly related to its potential to be developed as food and medicine.
In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease
Authors: Alugoju Phaniendra , Vishnu Bhandare Vishwambar , S. Patil Vishal , V. K. D Krishna Swamy , Borugadda Prem Kumar , Tencomnao Tewin
Published: March 2023

Background

Alzheimer's disease (AD) is a neurological condition that primarily affects older people. Currently available AD drugs are associated with side effects and there is a need to develop natural drugs from plants. Aquilaria is as an endangered medicinal plant genus (commonly called agarwood plants) and various products of Aquilaria plant spp. including resinous heartwood, leaves, bark, and stem have been widely used in various traditional medicine systems. Research on agarwood plants is sparse and only a few previous studies demonstrated their neuroprotective properties in vitro. Owing to the presence of a plethora of secondary metabolites in agarwood plants, it is imperative not only to protect these plants but also evaluate the bioactivity of agarwood phytochemicals.

Methods

Computational methods such as AutoDock Vina and molecular dynamic (MD) simulations were employed for the docking of 41 selected agarwood compounds with AD-related molecular targets. 

Results and Conclusion

According to docking data, three compounds aquilarisin, aquilarisinin, aquilarixanthone showed highest binding affinity to selected AD targets compared to their known inhibitors. MD simulation studies revealed that, selected agarwood compounds' protein-ligand complexes showed remarkable structural stability throughout 100 ns simulation. The agarwood chemicals aquilarisin, aquilarisinin, aquilarixanthone, pillion, and agarotetrol are consequently suggested as some of the found hits against AD targets, however, additional experimental validation is required to establish their effectiveness.
Sugar content and erosive potential of commonly prescribed Orodispersible tablets- An in vitro study.
Authors: Anand Lahari , Pentapati Kalyana , Shenoy Revathi , Yelleti Geethika , Kumar Saurabh
Published: March 2023

Background: Dental caries is a major non-communicable disease of public health concern caused due to freely available dietary sugars. We aimed to compare the sugar content and erosive potential with duration of use and drug classes of orodispersible tablets (ODTs). 

Methods: We conducted an in vitro evaluation of the total sugar content (TSC), Potential of Hydrogen (pH), solubility, and Titratable Acidity (TA) of commonly prescribed 62 ODTs. TA was measured by titrating the samples with known amount of. 0.1N sodium hydroxide (NaOH) with phenolphthalein indicator and pH was determined by digital pH meter. TSC was evaluated by phenol sulphuric acid. Solubility was assessed by filtration. 

Results: Out of the 62 ODTs, majority were Antimicrobials (n=30). One-quarter of the ODTs (26%) had a mean pH below ≤5.5. No significant difference was seen in the mean pH with respect to different drug classes (p=0.082) and duration of use of ODTs. A significant difference was seen in the mean percentage solubility with respect to drug classes (p<0.001). Antimicrobials had the least percentage of solubility as compared to other drug classes. Antiemetics and proton pump inhibitors (24.33 ± 17.34) had significantly higher mean percentage sugar content than Antimicrobials (23.25 ± 17.16). No significant difference was seen in the mean TSC with respect to various drug classes (p=0.718) and between the duration of use of drugs (P=0.568) respectively. No significant difference was seen in the mean percentage TA with respect to drug class (p=0.123) and duration of use of drugs (p=0.424). 

Conclusion: Overall, we can conclude that one in four ODT formulations had a pH below 5.5 (critical pH).  Only one ODT formulation did not have a sugar content. No difference was seen in the mean pH, sugar content, and TA with respect to duration of use of drugs and drug classes.
ecoSound-web: an open-source, online platform for ecoacoustics
Authors: Darras Kevin F.A. , Pérez Noemí , - Mauladi , Dilong Liu , Hanf-Dressler Tara , Markolf Matthias , Wanger Thomas C
Published: March 2023

Passive acoustic monitoring of soundscapes and biodiversity produces vast amounts of audio recordings, but the management and analyses of these raw data present technical challenges. A multitude of software solutions exist, but none can fulfil all purposes required for the management, processing, navigation, analysis, and dissemination of acoustic data. The field of ecoacoustics needs a software tool that is free, evolving, and accessible. We take a step in that direction and present ecoSound-web: an open-source, online platform for ecoacoustics designed and built by ecologists and software engineers. ecoSound-web can be used for storing, organising, and sharing soundscape projects, manually creating and peer-reviewing annotations of soniferous animals and phonies, analysing audio in time and frequency, computing alpha acoustic indices, and providing reference sound libraries for different taxa. We present ecoSound-web’s features, structure, and compare it with similar software. We describe its operation mode and the workflow for typical use cases such as the sampling of bird and bat communities, the use of a primate call library, and the analysis of phonies and acoustic indices. ecoSound-web is available from: https://github.com/ecomontec/ecoSound-web
Onufrij Wolanśkyj i idee ultramontanizmu w Kościele greckokatolickim na początku ХХ wieku
Authors: Lechniuk Roman
Published: March 2023

ONUFRIY VOLYANSKY AND IDEAS OF THE ULTRAMONTANISM IN GREEK-CATHOLIC CHURCH IN GALICIA IN THE EARLY 20TH CENTURY
The article analyzes the life and ideas of the Greek Catholic priest Onufriy Volyansky which are an infrequent example of the spread of ultramontane ideas among the Greek Catholic clergy in Galicia. The author examines the role of Volyansky’s studies, primarily at the Faculty of Theology of the University of Innsbruck, in shaping his worldview. Volyansky’s public-journalistic legacy is also considered in detail, first of all in the church magazine “Nyva”, because there his views can be seen in the most detailed and clear way. As a representative of ultramontanism – an idea that put the interests of the Catholic Church first, rather than individual nations or any other – Volyansky strongly opposed the spread of modern ideologies like socialism or liberalism, criticized various anti-church ideas that gained popularity in the early twentieth century. He contrasted them with the idea of the Church and Christian principles’ dominance in politics, culture, and other aspects of society. According to the author, the ultramontanism of Onufriy Volyansky had no chance to become a popular idea in the realities of the early twentieth century. However, his ideas are not without significance, and also show the involvement of at least part of the Greek Catholic clergy in the main intellectual debates that took place in the Catholic Church at that time.
Características anatómicas del conducto cístico en una muestra de cadáveres del anfiteatro de una institución universitaria en Bogotá Colombia.
Authors: Quijano Blanco Yobany , Rizo Tello Victor Zein
Published: March 2023

RESUMEN

Introducción. En comparación con otros países, los estudios sobre características anatómicas del conducto cístico son escasos.

Objetivo. Describir las características anatómicas del conducto cístico en una muestra de 60 especímenes cadavéricos en Colombia.

Materiales y métodos. Se realizó un estudio descriptivo analítico transversal donde se empleó y diseco el conducto cístico de 60 bloques digestivos humanos.

Resultados. Siguiendo la clasificación de Taybi, se encontraron variaciones con implantación alta (75%), baja (25%), en espiral anterior (1.6%), espiral posterior (1.6%), conducto cístico accesorio (1.6%) y doble conducto cístico (3.2%). En cuanto a las dimensiones del conducto cístico este presentó una longitud promedio de 19.4mm y un diámetro promedio de 3.3mm. Las características anatómicas usuales fueron similares a las reportadas en la literatura.

Conclusiones. La anatomía usual está presente en el 92% de los casos y las variantes anatómicas en el 8%. La longitud y el diámetro del conducto cístico están dentro del promedio reportado en la literatura.
Análisis de calidad de vida relacionada con salud oral en adultos con maloclusión
Authors: Díaz-Reissner Clarisse , Roldán-Merino Juan , Casas Irma
Published: March 2023

Introducción: Pacientes que requirieron tratamiento de ortodoncia reportaron impactos negativos en la calidad de vida relacionada con salud oral en comparación con aquellos pacientes con oclusión normal. Objetivo: Analizar la calidad de vida relacionada con salud oral en pacientes con diferentes niveles de severidad de maloclusión que acudieron a consultorios odontológicos públicos de Paraguay durante el año 2017. Metodología: Estudio transversal. Se midieron variables sociodemográficas como sexo, edad, residencia y nivel de estudios y variables clínicas como diastema, máxima irregularidad anterior maxilar y mandibular, resalte incisal y mordida cruzada anterior. Se utilizó el cuestionario Perfil de Impacto de Salud Oral en su versión paraguaya (OHIP-14Py) y el Índice de Estética Dental (IED). Resultados: Formaron parte del estudio 269 pacientes, la mayoría mujeres (75,1%). El puntaje IED fue de 31,35±11,56. Se observó resalte incisal aumentado (>2 mm) en poco más de la mitad (52,4%) y una baja frecuencia de mordida cruzada anterior (5,9%) y mordida abierta (10,0%). Al evaluar por dimensiones, la incapacidad psicológica (p=0,028), social (p=0,034) y minusvalía (p=0,552) aumentaron conforme el nivel de severidad de maloclusión, siendo estadísticamente significativa las dos primeras. Conclusión: Conforme aumenta la gravedad del nivel de maloclusión disminuye significativamente la calidad de vida oral para las dimensiones incapacidad psicológica e incapacidad social.
A corpus-based study of syntactic complexity of translated and non-translated chairman’s statements
Authors: Wang Zhongliang , Lui Kanglong , Moratto Riccardo
Published: March 2023

The chairman’s statement of the corporate annual report plays an important role in informing the decision-making of investors. Thus, it is often targeted at an international audience. The present study compares the syntactic complexity of translated chairman’s statements (Chinese to English) and non-translated ones (English), to determine the role that translation plays in conveying the chairman’s message. The results show that translated chairman’s statements are significantly simpler in subordination as well as overall sentence complexity, using fewer verbal phrases and T-units than the non-translated ones. However, translated chairman’s statements have longer length of production units, use more coordinate phrases and complex nominals than their non-translated counterparts. The findings indicate that simplification exists in half of the 14 syntactic complexity measures, providing some evidence for the simplification universal. They also reveal that in addition to translation universals, social factors also affect the complexity level of translated and non-translated chairman’s statements. The findings of the present study contribute to a systematic understanding of syntactic features of translated and non-translated chairman’s statements, enrich the present knowledge of translation universals and provide pedagogical implications for translation teaching and training in the context of Chinese-English translation.
The Winner’s Curse in Dynamic Forecasting of Auction Data: Empirical Evidence from eBay
Authors: Haruvy Ernan , Nia Meisam Hejazi , Özer Özalp , Şimşek A. Serdar
Published: March 2023

Problem definition: Dynamic forecasting models in auctions have fallen short on two dimensions: (i) the lack of an equilibrium model for final bids and (ii) the lack of a winner’s curse (i.e., a tendency to overpay conditional on winning the auction) adjustment to allow bidders to account for a common value component in the auction item. In this paper, we develop a methodology to accurately predict equilibrium stage bids from the initial bidding dynamics and quantify the impact of the winner’s curse. This methodology allows us to conduct policy simulations to optimize auction design parameters. Methodology/Results: Dynamic auctions typically have a stage of high exploratory activity, followed by an inactivity period, and then an equilibrium stage of last-minute bids with sharp jumps. With a Kalman filter approach, we use exploratory stage bids to predict an auction item’s valuation distribution. We feed this prediction into an equilibrium model and apply item-specific adjustments for winner’s curse, bidder heterogeneity, and inactivity period. We use the resulting equilibrium model to predict the equilibrium stage bids. Our methodology improves the forecast of equilibrium stage bids by 11.33%, on average, compared with a state-of-the-art benchmark. This improvement is even higher (18.99%) for common value auctions. We also find that (i) significantly more (respectively, fewer) bidders internalize the winner’s curse in common value (respectively, private value) auctions; (ii) bidders in common value auctions decrease their bids by 6.03% because of the winner’s curse; and (iii) the inactivity period has a lesser impact on the equilibrium stage bids in private value auctions. Managerial implications: Our proposed methodology is intended to facilitate the need in academia and practice for real-time bid predictions that encompass different levels of the common value component in auctions. Using our methodology, auction platforms can support their choice of minimum bid increment policies and decide how to allocate resources across different auctions to mitigate the adverse effects of the winner’s curse.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1165 .
Comparison of Language Development, Emotional and Behavioral Problems, Parental Attitude Characteristics, Parental Stress Level and Related Factors in Preschool Period, Between Preterm and Term-Born Children
Authors: GÜLLER Barış , YARCI Erbu , YAYLACI Ferhat
Published: March 2023

Objective: We aimed to investigate language development, emotional and behavioral problems, parental attitudes,
parental stress levels, and related factors in preschool period between children who were born preterm and term.
Material and Methods: We included 176 children, of whom 90 were born preterm and 86 term, and their mothers.
Mothers filled out the sociodemographic data form, Child Adjustment and Parent Efficacy Scale (CAPES-TR), Parenting
Stress Index-Short Form (PSI-SF), and Parenting Styles and Dimensions Questionnaire – Short Version (PSDQ) scales.
Denver II Developmental Screening Test (DDST) and Test of Early Language Development - Third Edition (TELD-3) were
applied to children.
Results: The mean age was 37.97±3.62 months for the preterm children, and 38.77±3.28 months for the term
children. The scores of preterm children were lower in the TELD-3 subtests. The rates of children with abnormal
development regarding personal social development and language development were significantly higher in preterm
children (p=0.007 for personal social development and <0.001 for language development, respectively). CAPES-TR
emotional and behavioral problems scores were higher in preterm children. CAPES-TR Parental Self-Efficacy Subscale
was lower in preterm children (p<0.001). PSI-SF total score and PSDQ permissive parenting subscale score were higher
in mothers of preterm children (p=0.005 and p<0.001, respectively).The preterm-born children were more commonly
diagnosed with language disorder and global developmental delay (p=0.006 and p=0.019, respectively). A positive
correlation was found between the week of birth, maternal education level and monthly income level and TELD-3
scores, DENVER personal social and language development level (p<0.050).
Conclusion: Our study revealed closer follow-up is important for preterm children to plan special education support when
it is necessary.
Jüvenil İdiopatik Artritli Hastalarda Leflunomid Tedavisinin Değerlendirilmesi: Tek Merkez Deneyimi
Authors: ARSLANOĞLU AYDIN Elif , ÖZDEL Semanur , BAGRUL Ilknur , KOCAMAZ Nesibe Gokce , BAĞLAN Esra , TUNCEZ Serife , BULBUL Mehmet
Published: March 2023

Amaç: Juvenil idiyopatik artrit (JİA), çocukluk çağının en sık görülen kronik romatizmal hastalığıdır. Metotreksat (MTX), leflunomid (LFN) gibi hastalık modifiye edici antiromatizmal ilaçlar (DMARD) JİA'da birinci basamak tedavilerdir. MTX en sık reçete edilen ilaçtır ve çalışmalar ağırlıklı olarak MTX etkinliğini ve güvenliğini ele almaktadır. Ancak LFN ile ilgili veriler sınırlıdır. Bu çalışmada, JİA hastalarında LFN tedavisi ile ilgili kliniğimizin deneyimlerini sunmayı amaçladık.
Gereç ve Yöntem: Bu retrospektif çalışmaya hastanemiz çocuk romatoloji polikliniğinde düzenli olarak takip edilen ve LFN tedavisi verilmiş JİA hastaları dahil edildi. Hasta demografik bilgileri, klinik ve laboratuvar özellikleri ile ilgili veriler tıbbi dosyalardan elde edildi.
Bulgular: Çalışmaya ortanca (çeyrekler arası aralık) hastalık başlangıç yaşı 7,3 (3,1-12,0) yıl olan 18 hasta (15 kadın ve 3 erkek) dahil edildi. 8 hastada oligoartiküler JİA, 7 hastada poliartiküler JİA, 2 hastada sistemik JİA ve 1 hastada entezitle ilişkili artrit (ERA) vardı. Tüm hastalara başlangıç tedavisi olarak MTX verildi (ERA tanısı konan bir hasta sulfasalazin ile tedavi edildi hariç). Gastrointestinal sistem (GİS) intoleransı nedeniyle başlangıçta MTX alan tüm hastalarda MTX kesildi ve LFN tedavisi başlandı. Daha önce MTX alırken GİS intoleransı gelişen hastalık aktivitesi düşük olan yedi hastadan altısına LFN tedavisi verildi. Bu hastalarda LFN ile tam remisyon sağlandı. MTX ile remisyonda izlenen dört hastada hastalık aktivasyonu görüldü. Daha önce MTX intoleransı olan bu hastalara LFN tedavisi verildi. Dört hastanın üçünde LFN ile remisyon sağlandı. MTX ile remisyon sağlanamayan orta ve yüksek hastalık aktivitesine sahip altı hastaya biyolojik tedavi başlandı. Yeterli yanıt alınamayan bu hastalarda MTX kesilerek LFN tedavisi başlandı. LFN ve biyolojik ajan kombinasyonu ile sadece bir hastada inaktif hastalık elde edildi. ERA tanılı bir hastada sulfasalazin tedavisine yetersiz yanıt alması üzerine LFN tedavisine geçildi ve LFN ile tam remisyon elde edildi.
Sonuçlar: LFN tedavisi, diğer DMARD'larla düşük hastalık aktivitesi ve/veya remisyonu olan ve ilaç kesildikten sonra nüks olan hastalarda faydalı olabilir.
A violência necropopulista do governo Bolsonaro e o ataque ao projeto constitucional de Estado de bem-estar social democrático no Brasil
Authors: Santos Andre Leonardo Copetti , Seadi Humberto Acacio Trez
Published: March 2023

Este trabalho tem como objetivo central demonstrar o caráter necropopulista das narrativas e ações políticas do governo Bolsonaro e o potencial de violência nelas contido contra o projeto constitucionalizado de bem-estar social e democrático. O artigo demonstra, em primeiro lugar, as bases ideológicas da social democracia que foi positivada no texto constitucional através de um modelo de Estado de bem-estar social. Em seguida, faz uma análise, a partir de uma tipologia da violência, acerca da possibilidade de considerar-se como violência, ações governamentais que, aparentemente, possam ser consideradas como opções políticas baseadas em uma visão de mundo particular. Por fim, procura desvelar o caráter de violência objetiva (sistêmica, estrutural e simbólica) que está arraigado a discursos, entrevistas e ações do governo de Bolsonaro, que atingem frontalmente e visam desestruturar o avanço civilizatório-constitucional que representou a positivação do Estado de Bem-Estar Social e Democrático na Constituição da República de 1988.
O cuidado ético da pessoa além do atendimento de saúde mental protocolar
Authors: Ikeda Walter Lucas , Teixeira Rodrigo Valente Giublin
Published: March 2023

O artigo apresenta um panorama do desenvolvimento das políticas públicas de saúde mental cujo atendimento é instrumentalizado por um rito protocolar estabelecido por normas e diretrizes que regulamentam o tema. Dessa maneira, o problema de pesquisa que orienta esta investigação é: em que medida o atendimento meramente protocolar cumpre um cuidado ético? A hipótese que se trabalha é que o protocolo embarga o cuidado ético, porque promove a despersonalização dos usuários do sistema único de saúde. O objetivo geral da pesquisa é analisar a relação entre as políticas de saúde mental e o cuidado ético dentro de um regime protocolar, com a finalidade de desenvolver uma crítica ética de alteridade. Dessa forma, estabelecem-se dois objetivos específicos, que correspondem à estrutura do texto em duas seções: a) apresentar um panorama das políticas de saúde no Brasil a partir de 1970, com o início do movimento antimanicomial; e b) analisar a questão do cuidado ético no protocolo de atendimento atual aos usuários de saúde mental no Brasil, a partir do conceito de alteridade de Emmanuel Lévinas. O método utilizado para a crítica ética é o fenomenológico, buscando delinear a análise da percepção intersubjetiva desencadeada no atendimento, em especial do Eu que atende em relação ao Outro atendido, a partir de Emmanuel Lévinas. Ao final da investigação, os resultados apontam a necessidade de um protocolo ético de cuidado que transcenda o mero atendimento protocolar, como condição de possibilidade da alteridade.
Effective evidence gathering for stress-free clinic inspections
Authors: Chauhan Taruna
Published: March 2023

Taruna Chauhan focuses on the requirements for the Care Quality Commission. In terms of evidence gathering, the same thinking applies for the other statutory bodies
Aesthetic nurse titles
Authors: King Sharon
Published: March 2023

Sharon King explores the various definitions of titles seen in aesthetic nursing and what that means for the practitioners and the public
Ten Years of Management of Esophageal Atresia in Benin: State of the Art, Experiences and Needs for Families of Children with Stoma
Authors: Samuel Boris Gogan Mahunakpon Vihotogbe Leon , Romeo Houegban Amoussou Sedjro Clotaire , Metchihoungbe Codjo Serge , Khen-Dunlop Naziha , Sergine Dossou Modoukpe Grace Immaculee , Covi Aldrico Pautin , Fiogbe Michel Armand , Gbenou Antoine Seraphin
Published: March 2023

Background/Purpose: Esophageal atresia (EA) is a congenital defect in the thoracic esophagus associated or not with a tracheoesophageal fistula (TEF). It is associated with high mortality in low-income countries such as Burkina Faso, Madagascar and Ghana. The purpose of this study was to present the recent management of newborns with EA/TEF in Benin and to identify the needs of families whose children have survived.

Method: Over a period of 10 years, 54 newborns with EA/TEF operated on in the 2 largest university hospitals in Benin were included. Two groups were identified. Group A (n=33) included newborns in whom a primary repair had been performed. Group B (n=21) involved newborns who underwent staged repair. Staged repair involved cervical oesophagostomy + gastrostomy (n= 7) or upper oesophageal pouch suction + gastrostomy (n=2) or cervical esophagostomy + stoma of the lower esophageal pouch (n=12). Ten parents from group B were interviewed for the needs survey. The significance level was defined as p < 0.05.

Results: There were 31 male newborns. The median for gestational age was 37 gestational weeks (range: 35 - 38). Polyhydramnios was observed in 4 cases. The mean birth weight was 2365 g. (range: 1000 g - 3500 g). The mean age at diagnosis was 3.48 days (range: 24 hours - 19 days). Surgery was performed at day 5 on average with extremes from day 2 to day 17. The surgery lasted an average of 2h12 min and the overall mortality rate was 74.07%. Mortality rate in group A was 100% and 33.33% in group B. There was a strong statistically significant difference in survival between the two groups. (p=19.10-8). Sepsis was the most common cause of death. Stress, fear and anxiety of losing the child were the difficulties frequently encountered at bedtime and every day. Four parents had to stop their activities to be available to take care of their child. All the parents had expressed the need for psychological support.

Conclusion: Pending an improvement of the technical platform, staged repair remains an essential option for the survival of patients. The creation of a framework for discussion with families authorizing social actions and quality medical support is desired.
The inverse Horn problem
Authors: Queiró João Filipe , Santana Ana Paula
Published: March 2023

Alfred Horn's conjecture on eigenvalues of sums of Hermitian matrices was proved more than 20 years ago. In this note, the problem is raised of, given an          $n$-tuple $\gamma$ in the solution polytope, constructing Hermitian matrices with the required spectra such that their sum has eigenvalues $\gamma$.
Periprosthetic joint infection in patients with multiple arthroplasties
Authors: Sangaletti Rudy , Zanna Luigi , Akkaya Mustafa , Sandiford Nemandra , Ekhtiari Seper , Gehrke Thorsten , Citak Mustafa
Published: March 2023

Aims

Despite numerous studies focusing on periprosthetic joint infections (PJIs), there are no robust data on the risk factors and timing of metachronous infections. Metachronous PJIs are PJIs that can arise in the same or other artificial joints after a period of time, in patients who have previously had PJI.

Methods

Between January 2010 and December 2018, 661 patients with multiple joint prostheses in situ were treated for PJI at our institution. Of these, 73 patients (11%) developed a metachronous PJI (periprosthetic infection in patients who have previously had PJI in another joint, after a lag period) after a mean time interval of 49.5 months (SD 30.24; 7 to 82.9). To identify patient-related risk factors for a metachronous PJI, the following parameters were analyzed: sex; age; BMI; and pre-existing comorbidity. Metachronous infections were divided into three groups: Group 1, metachronous infections in ipsilateral joints; Group 2, metachronous infections of the contralateral lower limb; and Group 3, metachronous infections of the lower and upper limb.

Results

We identified a total of 73 metachronous PJIs: 32 PJIs in Group 1, 38 in Group 2, and one in Group 3. The rate of metachronous infection was 11% (73 out 661 cases) at a mean of four years following first infection. Diabetes mellitus incidence was found significantly more frequently in the metachronous infection group than in non-metachronous infection group. The rate of infection in Group 1 (21.1%) was significantly higher (p = 0.049) compared to Groups 2 (6.2%) and 3 (3%). The time interval of metachronous infection development was shorter in adjacent joint infections. Concordance between the bacterium of the first PJI and that of the metachronous PJI in Group 1 (21/34) was significantly higher than Group 2 (13/38; p = 0.001).

Conclusion

The findings of this study suggest that metachronous PJI occurs in more than one in ten patients with an index PJI. Female patients, diabetic patients, and patients with a polymicrobial index PJI are at significantly higher risk for developing a metachronous PJI. Furthermore, metachronous PJIs are significantly more likely to occur in an adjacent joint (e.g. ipsilateral hip and knee) as opposed to a more remote site (i.e. contralateral or upper vs lower limb). Additionally, adjacent joint PJIs occur significantly earlier and are more likely to be caused by the same bacteria as the index PJI.

Cite this article: Bone Joint J 2023;105-B(3):294–300.
How long do ankle arthroplasties last?
Authors: Jennison Toby , Ukoumunne Obi , Lamb Sallie , Sharpe Ian , Goldberg Andrew J.
Published: March 2023

Aims

Despite the increasing numbers of ankle arthroplasties, there are limited studies on their survival and comparisons between different implants. The primary aim of this study was to determine the failure rates of primary ankle arthroplasties commonly used in the UK.

Methods

A data linkage study combined National Joint Registry (NJR) data and NHS Digital data. The primary outcome of failure was defined as the removal or exchange of any components of the implanted device. Life tables and Kaplan-Meier survival charts were used to illustrate survivorship. Cox proportional hazards regression models were fitted to compare failure rates between 1 April 2010 and 31 December 2018.

Results

Overall, 5,562 primary ankle arthroplasties were recorded in the NJR. Linked data show a one-year survivorship of 98.8% (95% confidence interval (CI) 98.4% to 99.0%), five-year survival in 2,725 patients of 90.2% (95% CI 89.2% to 91.1%), and ten-year survival in 199 patients of 86.2% (95% CI 84.6% to 87.6%). The five-year survival for fixed-bearing implants was 94.3% (95% CI 91.3% to 96.3%) compared to 89.4% (95% CI 88.3% to 90.4%) for mobile-bearing implants. A Cox regression model for all implants with over 100 implantations using the implant with the best survivorship (Infinity) as the reference, only the STAR (hazard ratio (HR) 1.60 (95% CI 0.87 to 2.96)) and INBONE (HR 0.38 (95% CI 0.05 to 2.84)) did not demonstrate worse survival at three and five years.

Conclusion

Ankle arthroplasties in the UK have a five-year survival rate of 90.2%, which is lower than recorded on the NJR, because we have shown that approximately one-third of ankle arthroplasty failures are not reported to the NJR. There are statistically significant differences in survival between different implants. Fixed-bearing implants appear to demonstrate higher survivorship than mobile-bearing implants.

Cite this article: Bone Joint J 2023;105-B(3):301–306.
An assessment of the impact of developmental dysplasia of the hip on patients’ wellbeing
Authors: Franco Helena , Saxby Nathan , Corlew Daniel S. , Perry Daniel C. , Pigeolet Manon
Published: March 2023

Aims

Within healthcare, several measures are used to quantify and compare the severity of health conditions. Two common measures are disability weight (DW), a context-independent value representing severity of a health state, and utility weight (UW), a context-dependent measure of health-related quality of life. Neither of these measures have previously been determined for developmental dysplasia of the hip (DDH). The aim of this study is to determine the DW and country-specific UWs for DDH.

Methods

A survey was created using three different methods to estimate the DW: a preference ranking exercise, time trade-off exercise, and visual analogue scale (VAS). Participants were fully licensed orthopaedic surgeons who were contacted through national and international orthopaedic organizations. A global DW was calculated using a random effects model through an inverse-variance approach. A UW was calculated for each country as one minus the country-specific DW composed of the time trade-off exercise and VAS.

Results

Over a four-month period, 181 surgeons participated in the survey, with 116 surgeons included in the final analysis. The global DW calculated to be 0.18 (0.11 to 0.24), and the country-specific UWs ranged from 0.26 to 0.89.

Conclusion

This is the first time that a global disability weight and country-specific utility weights have been estimated for DDH, which should assist in economic evaluations and the development of health policy. The methodology may be applied to other orthopaedic conditions.

Cite this article: Bone Jt Open 2023;4(3):120–128.
Error performance of an L-PPM modulated ADR-based MIMO-VLC system with and without channel estimation error
Authors: Dixit Vipul , Kumar Atul
Published: March 2023

In recent years, visible light communication (VLC) has emerged as a potential technique for beyond 5G communication networks. In this study, an angular diversity receiver (ADR) is used to propose a multiple-input multiple-output (MIMO) VLC system employing L-pulse position modulation (L-PPM). Repetition coding (RC) is used at the transmitter, while receiver diversity techniques such as maximum-ratio combining (MRC), selection best combining (SBC), and equal gain combining (EGC) are used at the receiver to improve performance. This study presents the exact probability of error expressions for the proposed system with and without channel estimation error (CEE). The analysis shows that the probability of error of the proposed system increases as the estimation error increases. Further, the study shows that the increase in signal-to-noise ratio is not enough to counter the impact of CEE, especially when the estimation error is large. The distribution of error probability of the proposed system using EGC, SBC, and MRC throughout the area of the room is presented. The simulation findings are compared to the analytical results.
Strongly enhanced sensitivities of CMOS compatible plasmonic titanium nitride nanohole arrays for refractive index sensing under oblique incidence
Authors: Han Weijia , Reiter Sebastian , Schlipf Jon , Mai Christian , Spirito Davide , Jose Josmy , Wenger Christian , Fischer Inga A.
Published: March 2023

Titanium nitride (TiN) is a complementary metal-oxide-semiconductor (CMOS) compatible material with large potential for the fabrication of plasmonic structures suited for device integration. However, the comparatively large optical losses can be detrimental for application. This work reports a CMOS compatible TiN nanohole array (NHA) on top of a multilayer stack for potential use in integrated refractive index sensing with high sensitivities at wavelengths between 800 and 1500 nm. The stack, consisting of the TiN NHA on a silicon dioxide (SiO2) layer with Si as substrate (TiN NHA/SiO2/Si), is prepared using an industrial CMOS compatible process. The TiN NHA/SiO2/Si shows Fano resonances in reflectance spectra under oblique excitation, which are well reproduced by simulation using both finite difference time domain (FDTD) and rigorous coupled-wave analysis (RCWA) methods. The sensitivities derived from spectroscopic characterizations increase with the increasing incident angle and match well with the simulated sensitivities. Our systematic simulation-based investigation of the sensitivity of the TiN NHA/SiO2/Si stack under varied conditions reveals that very large sensitivities up to 2305 nm per refractive index unit (nm RIU−1) are predicted when the refractive index of superstrate is similar to that of the SiO2 layer. We analyze in detail how the interplay between plasmonic and photonic resonances such as surface plasmon polaritons (SPPs), localized surface plasmon resonances (LSPRs), Rayleigh Anomalies (RAs), and photonic microcavity modes (Fabry-Pérot resonances) contributes to this result. This work not only reveals the tunability of TiN nanostructures for plasmonic applications but also paves the way to explore efficient devices for sensing in broad conditions.
Dynamic opto-mechanical eye model with peripheral refractions
Authors: Zhao Yanbo , Fang Fengzhou
Published: March 2023

Many myopia control methods based on the peripheral defocus theory have emerged towards applications in recent years. However, peripheral aberration is a critical issue, which is still not well-addressed. To validate the aberrometer for peripheral aberration measurement, a dynamic opto-mechanical eye model with a wide visual field is developed in this study. This model consists of a plano-convex lens representing cornea (f’ = 30 mm), a double-convex lens representing crystalline lens (f’ = 100 mm), and a spherical retinal screen with a radius of 12 mm. To optimize the quality of spot-field images from the Hartman-Shack sensor, the materials and surface topography for the retina are studied. The model has an adjustable retina to achieve Zernike 4th item (Z4 focus) ranging from -6.28 µm to +6.84 µm. As for mean sphere equivalent, it can achieve -10.52 D to +9.16 D at 0° visual field and -6.97 D to +5.88 D at 30° visual field with a pupil size of 3 mm. To realize a changing pupil size, a slot at the back of the cornea mount and a series of thin metal sheets with 2, 3, 4, and 6 mm holes are generated. Both on-axis aberrations and peripheral aberrations of the eye model are verified by a well-used aberrometer and the eye model to mimic a human eye in a peripheral aberration measurement system is illustrated.