bluuebunny/crossref_metadata_2025 huggingface dataset:
Neutron Activation Analysis of Trace Elements in Parkinson’s Disease
Authors: Danilova E. A. , Osinskya N. S. , Khanova M. N. , Khusniddinova S. Kh.
Published: October 2023

Relevance: Parkinson's disease along with secondary parkinsonism is the most common neurodegenerative disease of the elderly people and remains a serious medical and social problem. Parkinsonism

or shaking palsy is categorized as a chronic progressive brain disease. Studying the trace elements imbalance, determining their content in bio-substrates, particularly in hair, is one of the methodological

approaches for early diagnosis of the neurodegenerative processes and improving the methodology for

effective treatment.

Purpose: To investigate by neutron activation analysis the hair elemental composition of patients with

secondary parkinsonism in chronic liver failure (SPCLF) and to assess the imbalance of trace elements

affecting the severity and course of the disease.

Material and methods: The study involved 77 patients aged 30 to 82 years, including 21 patients with

parkinsonism syndrome in chronic liver failure, 29 patients with Parkinson's disease and 27 patients

with vascular parkinsonism.The trace element status of patients was studied by hair analysis using the

neutron activation method at the VVR-SM reactor of the INP.

Results: The hair elemental composition of patients with secondary parkinsonism in chronic liver failure was studied and the content of copper, manganese, selenium, chromium, zinc, cobalt and bromine

in the hair of all studied patients was determined. A comparative assessment of the elements imbalance in the studied groups was carried out. Correlation analysis between the elements revealed a positive correlation between manganese and iron (r =0.51) and a negative correlation between manganese

and bromine (r =–0.74) in the group of patients with secondary parkinsonism in chronic liver failure.

Conclusion: The imbalance of trace elements affecting the severity and course of the disease was assessed. It is shown that the revealed deficiency of copper, iron and zinc contribute to even greater accumulation of manganese in the basal ganglia, worsening the course of the disease.
Multi-Radionuclide in Vivo Imaging of Solid Tumors in Small Laboratory Animals for Experimental Oncology
Authors: Shpakova K. E. , Finogenova Y. A. , Skribitsky V. A. , Lipengolts A. A. , Smirnova A. V. , Skripachev I. A. , Bolshakov S. M. , Skribitskaya A. V. , Grigorieva E. Y.
Published: October 2023

Purpose: To show the feasibility of the simultaneous trimodal PET/SPECT/CT with 18F-FDG and 177Lu-DOTATATE for characterization of syngeneic subcutaneous mouse tumor model.

Material and methods: Female C57Bl/6 mice with transplanted subcutaneous melanoma B16F10 were

used for the study. Preclinical trimodal PET/SPECT/CT imaging system MiLabs VECTor 6 (Netherlands) was used. Mice from the first control group were intravenously injected with 177Lu-DOTATATE

and underwent SPECT/CT. Mice from the second control group were intravenously injected with 18F-FDG and underwent PET/CT. Mice from the experimental group were intravenously injected with 18F-FDG and 177Lu-DOTATATE in one syringe and underwent simultaneous PET/SPECT/CT imaging.

Results: Distribution pattern of each radiopharmaceutical 18F-FDG and 177Lu-DOTATATE in the tumor

of mice from experimental group was similar to the pattern, observed in control groups. 177Lu-DOTATATE was detected in the tumor periphery, and its concentration decreased with time. 18F-FDG

was detected in the tumor as a large homogeneous focus of hyperfixation and its concentration increased with time. Biodistribution of both tracers in the mouse organism, according to PET/SPECT/CT

after single injection, was similar to the distribution of the tracers individually in PET and SPECT.

Conclusion: The obtained results of the study confirm that neither physical or physiological interference nor chemical reaction between two tracers occurred. The tracers had no pharmacological influence on each other. The decrease of 177Lu-DOTATATE in experimental tumor indicated low level of SSTR

expression, the increase of 18F-FDG revealed high level of metabolic activity in the tumor.
Sustainable Tourism Development Index: A Scientifically Practical Proposal
Authors: Diakomihalis Mihail N , Diakomichalis Nikolaos-Marios
Published: October 2023

Sustainable tourism development requires self-limitation and the delimitation on national or regional development, within the frame of Carrying Capacity (CC), while maximizing economic benefits evaluated in the Tourist Satellite Account (TSA). Sustainable Tourism should be determined by Carrying Capacity while Development level should be depicted on Tourism Satellite Account, at national or at local level. The research question of this study is to define where the “golden ratio” is located between sustainability and economic benefits maximization. Tourism experts and academics evaluated the sub-criteria, based on the Analytic Hierarchy Process (AHP), which form the Sustainable Tourism Index, within the framework of environmental protection, natural sources savings, eco-friendly practices, green investments, and of the highest contribution to GDP, to employment, to local income and to local and federal tax revenues. The results will support local and federal policy makers to design and apply tourism development ensuring sustainability.
Sentencias
Authors: Cabanillas Sánchez Antonio
Published: October 2023

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Su Güvenliği Bağlamında Nil Havzası Girişimi’nin (NHG) İklim Değişikliğine Yönelik Uyum ve Azaltım Stratejileri
Authors: İLKBAHAR Hasan
Published: October 2023

İklim değişikliği, insanoğlunun karşılaştığı en önemli sorunlardan biri olarak kabul edilmiştir. Bu nedenle iklim değişikliğine yönelik acil çözümler küresel siyaset gündemini meşgul etmiştir. Kyoto Protokolü ve Paris İklim Anlaşması önemli gelişmeler olarak kabul edilmiştir. Bununla birlikte, bölgesel örgütler de iklim değişikliğinin ele alınmasında önemli rol oynamışlardır. Bu bağlamda, 1999’da kurulan Nil Havzası Girişimi (NHG) genellikle bölgedeki adil su paylaşımı, kullanımı ve yönetimi ile ilgilenmiş olsa da, iklim değişikliği ve bunun havzadaki su, gıda ve enerji güvenliği üzerindeki olumsuz etkilerini de gündemine almıştır. Bu nedenle, NHG’nin yeni oluşturulan stratejileri çoğunlukla su güvenliği temelinde iklim değişikliğine uyum ve azaltım konularını içermektedir. Bununla birlikte NHG’nin bu politikalarının yeterince başarılı olmadığı gözlenmiştir. Bu bağlamda çalışma, NHG tarafından yayınlanan politika belgeleri, dokümanlar ve raporlar ile üye devletlerin politikaları üzerinden söz konusu başarısızlığın nedenlerini analiz etmeyi amaçlamaktadır.
A NOITE DAS BRINCADEIRAS MORTAIS (1986) COMO ‘ANTI-SLASHER’: UMA PROPOSTA DE ANÁLISE
Authors: Cánepa Laura Loguercio
Published: October 2023

Este trabalho discute o filme A Noite das Brincadeiras Mortais (April Fool’s Day, Fred Walton, EUA, 1986), que pertence ao primeiro ciclo dos filmes de horror slasher, feitos principalmente nos EUA, na década de 1980, para o público adolescente. Nossa análise buscará destacar um aspecto que singulariza A Noite das Brincadeiras Mortais dentro desse ciclo, que é seu caráter farsesco e, por isso, autorreflexivo e crítico, antecipando, talvez de modo mais radical, sátiras que entrariam em voga a partir do final da década de 1990. Para realizar essa discussão, recorreremos aos debates sobre os filmes slasher (Dika, 1987; Clover, 1992; Piñedo, 1997; Clayton, 2015; Roche, 2016) e ao enquadramento desse subgênero na tradição do horror como espetáculo de choque, especialmente a partir da herança do Théatre du Grand Guignol (Schneider, 2001; Hand & Wilson, 2002; Ndalianis, 2012).
The Effect of Clinical Decision Support System on the Rates of Patients Who Reapply to the Emergency Department with the Same Diagnosis
Authors: ÖZKAN Elife , KÖSE İlker
Published: October 2023

Aim: We aim to decrease readmissions with the same diagnosis within 24 hours in emergency departments when many patients are admitted, such as during a pandemic.
Methods: A comparison was made between the quarterly and monthly increases in 2021, 2020, and 2019 during the pandemic period. The root cause analysis determined that non-branch physicians and after-hours visits contributed to the increase in readmissions to the emergency department within 24 hours. A complete digital structure in State Hospital, Hospital Information Management System level 7 has enabled standardized diagnosis by eliminating physician and branch-based differences with the decision support systems established by the Hospital Information System by utilizing digital measures. Cross-sectional and retrospective reapplication rates 2019, 2020, 2021 2nd Period (April, May, June). Quality Standards in Health Emergency Department two data sets were used as The Basic Health Statistics Module data. Result as the 2019, 2020, and 2021 monthly reapplication rates of emergency department 2nd Period (April, May, June) month comparison Application rates 2020-year 2nd Period. Looking at the same months in 2021 and 2020, it is seen that the reapplication rate decreased below 2% within 24 hours.
Results: This means that the application rate has returned to pre-pandemic levels. It is aimed at making it easier and more effective to work in situations that lead to collective admissions to emergency hospital services. The same situation has been an example of similar practices within hospital services.
Conclusion: The application rate returned to its status outside the pandemic period. Differences in physician-induced approaches to diagnosis and treatment were eliminated, and standardization was achieved.
Evaluation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Covid-19 Patients Treated with Tocilizumab Due to Cytokine Storm
Authors: DUKSAL Faysal , BURNİK Cengiz , YAVUZ Serkan , MERMER Mehmet
Published: October 2023

Background/Aims: There is a significant increase in proinflammatory cytokine levels in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients entering cytokine storm. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), also increase in inflammatory diseases. The aim was to evaluate the NLR and PLR of coronavirus disease 2019 (COVID-19) patients receiving tocilizumab (TCZ) due to cytokine storm.
Materials and Methods: In this retrospective, cross-sectional study conducted in between March and December 2020, adult patients with laboratory-confirmed COVID-19 were analyzed
Results; The mean age of 519 patients included in the study was 61.6 ± 17.0 years, with male predominance (64.7%). 70.7% of patients had at least one type of comorbidity and the most common comorbid conditions were chronic obstructive pulmonary disease (45.9%) and asthma (28.7%). 399 patients who were given TCZ (group 1) and 120 patients who were not given TCZ (group 2) were evaluated. Compared with group 2, group 1 had more male predominance and they were older (p<0.001). The mortality rate, which was found to be 48.6% in group 1, was approximately twice as high in the intensive care unit (ICU). NLR and PLR were significantly higher and lymphopenia was more prominent in group 1, especially in ICU patients than group 2 (p<0.001).
Conclusion: High NLR, PLR and lymphopenia was more common in critically ill Covid-19 patients. Therefore, they may be used as a marker to predict poor prognosis. It can be suggested to treat these patients more aggressively in the initial period.
An Ensemble Learning Approach for detection of Chronic Kidney Disease (CKD)
Authors:   Department of CSE, PVP Siddhartha Institute of Technology, Vijayawada, India, Swamy B. Narasimha ,   Department of CSE, Seshadri Rao Gudlavalleru Engineering College, India,   Department of Computer Science and Engineering, Symbiosis Institute of Technology, Symbiosis International University, Pune, India; IEEE Senior Member, Symbiosis International University, Pune, India,   Department of CSE, PVP Siddhartha Institute of Technology, Vijayawada, India,   Department of Information Technology, MLR Institute of Technology, Hyderabad,   Gwangju Institute of Science and Technology, South Korea, Nakka Rajeswari , Sharma Aditi , Praveen S. Phani , Thatha Venkata Nagaraju , Gautam Kumar
Published: October 2023

Chronic kidney disease (CKD) is a common and possibly fatal condition affecting billions worldwide. Early detection and accurate diagnosis of CKD are critical for timely intervention and improved patient outcomes. In recent years, machine learning techniques have shown great promise in assisting medical professionals in detecting and diagnosing various diseases. This study aims to develop a novel machine learning (ML) model for detecting CKD using clinical and demographic data. The dataset used in this study comprises a comprehensive collection of patient records, including laboratory test results, medical history, and demographic information. Feature selection is one of the techniques that, combined with the ML approach, select the significant features. Several ML algorithms were implemented to detect CKD in the early stages but identified the issues with existing ML algorithms. The developed models' performance is assessed using precision, accuracy, and recall metrics. Additionally, feature importance analysis is conducted to identify the key factors influencing CKD diagnosis. The strength of the proposed approach shows accurately by identifying the individuals at risk of CKD and distinguishing between different stages of the disease. The dataset used for this research was collected from the UCI repository, which consists of 25 attributes, 550 samples, 400 CKD affected, and 150 standard models. The dataset consists of two folders, training and testing. The training utilizes 1000 samples with detailed patient health conditions. The developed CKD detection model shows promising results, achieving high accuracy of 97.98%. on the test dataset. By leveraging machine learning algorithms, this approach can assist healthcare professionals in making more informed decisions regarding early intervention and personalized treatment plans for patients with CKD. Ultimately, applying machine learning techniques in CKD detection can improve patient outcomes and reduce healthcare costs.
Saccharomyces cerevisiae como cultura de levedura com meio fermentativo melhora o desempenho de bovinos confinados
Authors: Oliveira Paulo Eduardo Piemontez de , Souza Andre Martins de , Heker Junior Julio Cezar , Sidor Fernando de Souza , Cristo Fernando Braga , Costa Luísa da , Nascimento Mariana Quintino , Figueiredo Adriana Nogueira , Manzano Ricardo Pereira , Neumann Mikael
Published: October 2023

Elevar o teor energético da ração dos animais tem por intuito potencializar o desempenho produtivo e promover melhor acabamento nas carcaças. No entanto, esta ação quando realizada ao acaso pode gerar disfunções no trato gastrointestinal que comprometem o desempenho. Uma forma de evitar tais disfunções é administrar leveduras Saccharomyces cerevisiae de forma suplementar na ração dos animais. O objetivo do presente estudo foi avaliar o efeito do uso de Saccharomyces cerevisiae, como cultura de leveduras ou como levedura autolisada, no comportamento ingestivo, digestibilidade aparente da ração, desempenho produtivo e as características de carcaça de novilhos terminados em confinamento. Foram utilizados 36 animais ½ Angus x ½ Nelore com peso corporal médio inicial de 369 ± 4 kg. O experimento teve duração de 133 dias divididos em 28 dias de adaptação às rações e instalações experimentais, e quatro períodos de avaliação, sendo três períodos de 28 dias e um quarto período de 21 dias. O delineamento experimental foi de blocos inteiramente casualizados com três tratamentos e seis repetições. Os tratamentos foram: ração sem leveduras (Controle); ração com cultura de leveduras (7 g animal-1 dia-1); e ração com levedura autolisada (7 g animal-1 dia-1). A ração experimental foi constituída por 400 g kg-1 silagem de milho e 600 g kg-1 concentrado em base de matéria seca. Os animais suplementados com cultura de leveduras permaneceram mais tempo ruminando e apresentaram maior digestibilidade aparente da matéria seca em relação aos demais (5,94 horas dia-1 e 74,67%, respectivamente).  O uso de cultura de leveduras promoveu maiores ganhos de peso diário de 0-56, 0-84 e de 0-105 dias (1,661, 1655 e 1,667 kg dia-1, respectivamente) em relação aos animais que receberam levedura autolisada e aos que não receberam nenhum aditivo, assim como a conversão alimentar foi melhor para estes animais. Os ganhos de carcaça diário e do período experimental foram superiores para os animais que receberam cultura de leveduras em suas rações (1,119 kg dia-1 e 117,5 kg respectivamente). Os animais suplementados com cultura de leveduras possuíram maior espessura de gordura no Longissimus dorsi, na região do costilhar e maior ganho de gordura subcutânea ao longo do período de terminação (5,61, 6,25 e 3,04 mm, respectivamente). O uso da cultura de leveduras na fase de terminação é recomendado, pois melhora a digestibilidade da ração e promove maior ganho de peso, ganho de carcaça e maior deposição de gordura subcutânea.
Avaliação nutricional e laboratorial como preditores do tempo de hospitalização, gravidade da doença de base e mortalidade em cães
Authors: Fabretti Andrei Kelliton , Siqueira Raquel Carolina Simões , Gomes Lucas Alécio , Venturini Danielle , Pereira Patrícia Mendes
Published: October 2023

Prognóstico é definido na medicina, como uma predição baseada no diagnóstico do paciente e nas possibilidades terapêuticas, acerca da duração da enfermidade, gravidade da doença e taxa de óbito. Os índices de prognóstico utilizados em medicina humana ou mesmo os poucos padronizados para medicina veterinária não são muito difundidos ou aplicados na clínica de pequenos animais. Dessa forma, esta pesquisa objetivou identificar variáveis de uso comum na rotina clínica que possam ser úteis como marcadoras de prognóstico, se correlacionando, especificamente como o tempo de internamento (TI), gravidade de doença e mortalidade. Para tal, foram avaliados 246 cães da rotina de um hospital veterinário escola do sul do Brasil, estudados em relação ao estado nutricional (EN) (por anamnese, exame físico e laboratorial), exames hematológicos e diversos parâmetros bioquímicos séricos. Foram calculadas as frequências, médias e desvios-padrões das variáveis, análises de correlação e análises comparativas (Kruskal-Wallis em α = 5%). Foram considerados marcadores relevantes de gravidade de doença em cães: presença de desnutrição, incluindo histórico de hiporexia, anorexia, escore de condição corporal (ECC) ≤3 e escore de massa muscular (EMM≤2); baixos valores de transferrina (TF), da capacidade total de ligação ao ferro (CTLF) e anemia; além de valores elevados de índice de saturação da transferrina (IST), lactato e da relação PCR/albumina. Nos animais sem doenças sistêmicas ou com doenças sistêmicas discretas a moderadas, os indicadores de elevado TI foram: baixos valores de albumina, relação Proteína-C-Reativa (PCR)/Albumina e hiporexia. Nos animais com doenças sistêmicas críticas, os indicadores de baixo TI (secundários a alta mortalidade) foram: baixos valores de índice de massa corporal (IMC) e hemoglobina (HB). Os indicadores de mortalidade em cães doentes foram: hipoalbuminemia e elevada concentração de ureia. Conclui-se que a constatação dessas alterações, especialmente quando ocorrem simultaneamente, embasa a determinação do prognóstico em cães de uma população hospitalar, de maneira objetiva, prática e acessível.
Características e diferenças nos sintomas dos períodos menstrual e pré-menstrual em mulheres sedentárias
Authors: Zago Laura , Lima-Trostdorf Talitha , Macedo Christiane de Souza Guerino
Published: October 2023

Objetivo: Estabelecer as diferenças de sintomas físicos e mentais nos períodos menstrual e pré-menstrual em mulheres sedentárias. Métodos: Estudo transversal, por questionário, respondido por 77 mulheres saudáveis, de 18 a 35 anos, sedentárias e que não fizessem uso de anticoncepcional continuamente. O questionário incluiu questões sobre dados antropométricos, sintomas físicos e mentais nos períodos menstrual e pré-menstrual. O teste Mann Whitney comparou os momentos menstrual e pré-menstrual.Resultados: No período menstrual, em uma escala numérica de 0 a 10 pontos, observou-se maiores queixas de dor (7/10), mau humor (7/10), desânimo (8/10), irritabilidade (8/10), ansiedade (7/10), choro (7/10), raiva (9/10) e impacto nas atividades de vida diárias (AVDs) (7/10). Já no período pré-menstrual observou-se queixas de cefaleia (5/10), edema/retenção hídrica (6/10), mau humor (6/10), tristeza (6/10), irritabilidade (7/10), choro (7/10) e raiva (6/10). Quando comparados o período menstrual e pré-menstrual, o período menstrual apresentou piores sintomas de dismenorreia (P<0,05), lombalgia (P<0,05), dor nos membros inferiores (P<0,05), dificuldade de concentração (P<0,05), aumento do sono (P<0,05) e desânimo (P<0,05). As voluntárias apontaram 14 sintomas piores, com intensidade igual ou maior que sete no período menstrual, e apresentarem 9 sintomas com intensidade igual ou maior que sete no7 período pré-menstrual.Conclusão: Os sintomas no período menstrual são mais intensos quando comparados ao período pré-menstrual e podem afetar AVDs. O presente estudo destaca a importância de análises e cuidados em relação do período menstrual já que tem grande impacto nos fatores físicos, mentais e emocionais das mulheres sedentárias.
Avaliação dos atributos acesso, coordenação e Integralidade na atenção primária à saúde da criança
Authors: Dornelles Bárbara de Andrade Alves , Tacla Mauren Teresa Grubisich Mendes , Rossetto Edilaine Giovanini , Toso Beatriz Rosana Gonçalves de Oliveira , Fontana Louise Marina Silva , Souza Gisleine Tiemi de , Gabani Flávia Lopes
Published: October 2023

Objetivo: avaliar os atributos acesso, coordenação e integralidade da Atenção Primária à Saúde das criançasmenores de 12 anos, em município do Sul do Brasil. Método: trata-se de pesquisa quantitativa, avaliativa, parte deestudo multicêntrico, em que foram avaliados registros de 39 unidades básicas de saúde. Utilizou-se o instrumentoPrimary Care Assessment Tool versão criança, aplicado a 609 cuidadores, para avaliação dos atributos acesso(utilização e acessibilidade), coordenação (integração de cuidados e sistema de informações) e integralidade(serviços disponíveis e prestados). Valores de escores maior ou igual a 6,6 foram definidos como elevados eequivalentes ao valor 3 ou mais da escala Likert. Resultados: Apresentaram grau de orientação satisfatório paraAtenção Primária à Saúde os atributos acesso de primeiro contato-utilização (9,4), coordenação-integração decuidados (7,4), coordenação-sistema de informações (7,6) e integralidade-serviços prestados (6,9). Menoresescores foram observados nos atributos acesso de primeiro contato-acessibilidade (4,8), e integralidade-serviçosdisponíveis (6,5). Conclusão: O vínculo com a Atenção Primária à Saúde é bom, porém há necessidade deaumento da oferta de consultas, agilidade nos atendimentos e ampliação de recursos tecnológicos de comunicação.Também se sugere aumento da disponibilização de serviços especializados às crianças com necessidades especiais.
Role of Preoperative Nerve Conduction Studies for Penetrating Hand Injuries Involving the Median Palmar Cutaneous Nerve
Authors: Patel Saral , Hutchinson David , Arango Sebastian D. , Miller Andrew J. , McBeath Rowena
Published: October 2023

Penetrating lacerations to the hand are a common cause of nerve injury and can lead to debilitating pain and numbness in the distribution of the nerve affected. Owing to an overlap in the cutaneous innervation from different sensory nerves, clinically identifying the injured nerve can be difficult. We present a novel case of isolated injury to the palmar cutaneous nerve from a penetrating knife injury which was detected using ‘comparison waveform’ nerve conduction studies. Using this technique, we can isolate injuries to the palmar cutaneous branch of the median nerve (PCBmdn) from the median nerve, dorsal radial sensory nerve, and lateral antebrachial cutaneous nerve. In addition, sensory nerve testing identified conduction block as the mechanism of injury, which resolved after surgery at 8 weeks postoperatively. Preoperative nerve conduction study can discern the level of nerve injury to PCBmdn only, thus eliminating the need for median and radial nerve exploration at the forearm, unnecessary incisions, pain, and scarring. The objective of this case report is to illustrate the value of preoperative comparison waveform nerve conduction study, particularly the PCBmdn, in patients presenting with neurologic deficits who have sustained penetrating lacerations to the hand.
Editorial Review on Volume 8 Issue 2
Authors: Magnano Paola
Published: October 2023

N/A
Assessment of antitubercular treatment induced adverse drug reactions data at a tertiary care hospital
Authors: Shanmugam Deepa , Mukhyaprana Sudha , Selvakumar Gomathi , Devipriya Siddiraju , Chandramouliswaran Ramachandra
Published: October 2023

Background: Standard anti-tuberculosis (TB) treatment is highly effective, but managing adverse drug responses is a major challenge that can negatively affect treatment compliance and outcomes of an anti-tubercular treatment (ATT) regimen. Hence, monitoring of these adverse drug reactions (ADRs) is very essential wherein the drug-causing ADR can be detected and an appropriate therapeutic regimen can be given to the patient.

Aims and Objectives: To assess the ATT-induced ADRs in Individual Case Safety Reports (ICSRs), to find the incidence and prevalence of ADRs due to ATT, and to analyze the causality assessment of the ADRs due to ATT.

Materials and Methods: A retrospective observational study was carried out using spontaneous ICSRs data from the ADR monitoring centre at Madras Medical College, Chennai. A suspected adverse drug reaction reporting form (sADR reporting form) provided by the Pharmacovigilance Programme of India was used to collect the data of an ICSR.

Results: A total of 93 ICSRs were assessed during the study period. The majority of the ADRs occurred in males (n = 55), and the maximum number of ADRs were found in the age group of 18–44 years (n = 46). The majority of the ICSRs were categorized as “serious” (n = 60), of which the maximum number of ADRs belonged to the “hospitalization/prolonged hospital stay” category (n = 45). Most of the suspected ATT drugs involved in implicating ADRs were found to be fixed-dose combination pills of Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol (n = 71). Most of the ADRs were “skin and subcutaneous disorders” (n = 51) of the system organ class. The outcome of the ADRs was assessed and found that the majority of them were in the “recovering” (n = 54) category, and the majority of the ICSRs were found to be “probable” (n = 67).

Conclusion: An effective implementation of a Pharmacovigilance system with early detection and management of ADRs is needed to overcome the nonadherence to TB therapy.
Evaluate the impact of foundation course conducted at the level of 1st-year MBBS students at Assam Medical College, Dibrugarh – A student perspective
Authors: Baruah Mauchumi , Begum Tazkira , Bora Rituparna , Dastidar Abhijit
Published: October 2023

Background: Since 2019, the Medical Council of India (MCI) has started to introduce Competency-based Medical Education, which highlighted the importance of an 1-month duration foundation course. This period is considered necessary for the students to adapt to the new environment in the college. The present study was done to evaluate the impact of foundation course conducted at the entry level of MBBS students.

Aims and Objectives: The objectives of the study are as follows: 1. Evaluate the input of the students on all the topics of the Foundation course modules and 2. Based on student’s input, improve the course for future sessions.

Materials and Methods: All the new 1st-year medical students admitted in November 2022 were the study subjects. The guidelines laid down by the MCI were followed when implementing the foundation program. A pre-designed Google Form questionnaire, which included items that were appropriate to the research question, was circulated among the students, and input from them was used to evaluate the program. Feedback was received from students using a three-point Likert Scale.

Results: It was observed that after the implementation of the 1-month duration foundation course, knowledge of the students as well as the need and the importance regarding all the modules increased and was found to be extremely significant statistically (P < 0.0001).

Conclusion: Overall, the sessions in the foundation were positively received by the students. The information thus gathered will enable us to enhance the program for the following year and fulfill the objectives of the course.
Blockchain Data Analytics: A Review
Authors: Rabia Aslam Khan  , Muhammad Bilal But  , Sabreena Nawaz
Published: October 2023

Blockchain technology has emerged as a transformative force with widespread applications across various industries. In particular, the analysis of blockchain data has become crucial for crypto businesses and financial institutions seeking to protect transactions from illicit activities, minimize the risk of financial crimes, and ensure compliance with regulations. This paper presents a comprehensive review of blockchain data analytics, focusing on its significance in these domains. The paper examines the advancements and possibilities in blockchain data analytics, shedding light on their transformative potential. It provides an overview of the techniques and tools used for analyzing blockchain data, including transaction tracing, pattern recognition, and anomaly detection. Moreover, it explores the challenges and opportunities associated with blockchain data analytics, such as scalability, privacy concerns, and regulatory frameworks.
Health hazards from chemical substances and ionizing radiations
Authors: Shahid Saman
Published: October 2023

Ionizing radiation (IR) is known to probe the DNA-damaging effects and hence the risk of cancer can emerge. This small cohort study aimed to evaluate the lifetime fatal cancer risk (FCR) and non-fatal cancer risks (NCR) from IRs and compared them with the risks of other chemical substances (Nickel, Arsenic, Benzene & Asbestos) in nuclear medicine (NM) workers of the INMOL cancer hospital, Lahore. The procedure for the FCR and NCR risk calculation was followed through the guidelines of ICRP and UNSCEAR using probability coefficient. A high-capacity TLD reader was used to calculate whole-body AAED (annual average effective dose) (mSv). All occupational cancer risks were compared with the risks from other chemical substances through the Mann-Whitney U test. The FCRs were decreased from 7.854 10-4 to 3.836 10-4, similarly NCRs were also decreased from 1.57 10-4 to 7.672 10-4 in NM workers from 2015-2019. The fatal/non-fatal cancer risks from IR in INMOL hospital workers were found considerably lower than the risks from other carcinogenic substances. Significant differences existed between the IR fatal/non-fatal cancer risks with the risk values of other chemical substances. The standard risk value (2.80 10-2) of IR dose-effect can be used to compare the lifetime cancer risk from the other chemical substances in the occupational workers who are continuously being exposed to toxic substances occupationally.
Removal of nickel ions from aqueous solution using treated rice husk: an adsorption study
Authors: Irfan Muhammad Zahid , Qamar Sabih , Saeed Usman , Ali Meesam , Aleem Waqas , Qamar Nida , Shahid Arbab , Rehman Zia Ur
Published: October 2023

This article deals with the biosorption of nickel metal on the surface of rice husk and its acid treated form under batch experimentations. Various parameters were studied such as time, concentration of synthetic solution, pH and bio sorbent dose to determine the effect of adsorption of nickel metal on the surface of rice husk. Equilibrium time was found to be 92 min. The amount of nickel adsorbed increased with increase in their contact time. It was found that acid treated rice husk has good ability to remove highest amount of nickel in comparison with raw form of rice husk. The percentages for the removal of nickel was achieved as 86% and 66% for treated and raw form of rice husk respectively. It could be concluded that the removal efficiency was enhanced by increasing wastewater initial concentration in the first percentage of adsorption and then decreased due to saturation of rice husk particles.
Removal of heavy metals from wastewater of textile industry using polymeric nano-adsorbent
Authors: Khan Waqar Ali , Masood Hafiz Miqdad , Shahzad Khurram , Imran Muhammad , Ali Najaf , Naveed Ahmad
Published: October 2023

Wastewater of textile industry having impurities and heavy metal ions cause problems in human society that can endanger the human health through food chain. Adsorption of heavy metal ions before draining makes wastewater safe for aquatic life and human health. Now a days adsorption of heavy metal through polymeric Nano adsorbent is the emerging technology which is more efficient than conventional adsorbents like activated carbon. The pH 9.0 gave maximum 96% sorption of Co at 1.0 g/L adsorbent dosage, due to increased electrostatic force of attraction produced by the negative charge at the surface of sorbent which is favorable for adsorbing cationic species. In the beginning of 15 minutes retention time, metal ions adsorption was faster due to availability of more number of adsorptive sites but further increase of retention time decreased the sorption due to partial desorption that may occur due to the charge density and diameter of hydrated ions. Similarly in case of Cu, the maximum sorption was 95% at 7.0 pH using 1.0 g/L adsorbent dosage.
Evaluation of energy sources from municipal solid waste of Gujranwala city in Pakistan
Authors: Siddiqi Aijaz Ahmad , Ali Chaudhry Haider , Iqbal Tanveer , Mehmood Khan Haris , Iqbal Muhammad Waqas , Irfan Muhammad
Published: October 2023

The worldwide atmosphere has been seriously deteriorating due to the poor handling of waste produced in order to get useful products for achieving the high living standards and technological development. Therefore, waste management is a serious concern to avoid ecological damage. Methane gas generated on waste landfill sites is the source of greenhouse gas that is prime contributors to environmental degradation. The main intention is to measure the amount of methane gas produced from Municipal Solid Waste (MSW) at the site of Bakhrewali in the Cantonment (Rahwali), Gujranwala, Pakistan and to estimate the extent of energy that potentially could be retrieved from the MSW site. The waste samples were gathered to evaluate the energy content, composition, and methane concentration. The findings from the MSW characterization revealed that the primary constituent of Bahrewali site, Gujranwala MSW is organic waste. The concentration of methane from sites 1, 2 and 3 were analysed to be 118.45, 35.32, 48.26 ppm methane/g waste. The calorific value of samples 1, 2 and 3 were determined to be 13.45, 12.24, and 11.01 MJ/kg respectively. The outcomes confirm that there is production of methane at the waste sites and the municipal waste could be utilized for energy recovery. The analysis of samples collected from MSW sites shows that there is great potential in the waste to be combusted and used for electricity generation.
Modelling of the isothermal vapor-liquid equilibrium of alternative refrigerants: Determination of phase diagrams (high-pressure/low-pressure) and optimized binary interaction parameters
Authors: MADANI Hakim , Zerfa Abdnour , Maalem Youcef , Beicha Abdellah
Published: October 2023

In this work, a thermodynamic model for prediction of Vapor-Liquid Equilibrium (VLE) at moderate pressures (up to 19 bar) and different temperatures (288-323 K) is developed by using Soave-Redlich-Kwong (SRK) and Peng-Robenson (PR) equations of state (EoS) in combination with the classical van der Waals (vdW) mixing rules. Four refrigerant binary systems have been considered in this study (R134a+ R1336mzz (E)), (R600a+R1234ze (Z)), (R600a+R1243zf), (R744+R152a). Also, a new method was used to improve binary interaction parameters (kij). A comparison of experimental phase equilibrium data in the literature with the predicted results showed very good representation for some mixing rules.
A IMPORTÂNCIA DO PROJETO ELÉTRICO RESIDENCIAL NA SEGURANÇA E EFICIÊNCIA ENERGÉTICA
Authors: Morais Vinícius Oliveira , Gualberto Fabisleine Vieira Cabral , De Melo Júnior Gilmar Fernando
Published: October 2023

A eletricidade vem crescendo de maneira acelerada nas últimas décadas, sendo de suma importância para população moderna onde os equipamentos elétricos e eletrónicos fazem parte do cotidiano dos mesmos, com isso se torna mais importante a necessidade de projetos elétricos para dimensionamento de equipamentos de proteção e condutores elétricos para seu melhor desempenho e segurança.  O presente estudo bibliográfico foi para avaliar a importância dos projetos elétricos em residências, evitando os riscos aos moradores, abordando a necessidade de projetos e dimensionamentos dos equipamentos dentro das residências. A abordagem metodológica deste trabalho está organizada no formato de uma revisão de literatura, que inclui um diálogo exploratório e bibliográfico de natureza qualitativa. Os resultados deste estudo destacam que a execução de projetos elétricos em conformidade com as Normas Brasileiras Regulamentadoras (NBR) não apenas proporciona segurança nas residências, mas também contribui para o melhor desempenho na proteção dos equipamentos elétricos. Este artigo ressalta a relevância dos projetos elétricos residenciais como um pilar essencial para a segurança e eficiência energética nas residências modernas, enfatizando a necessidade.
OS IMPACTOS PSICOLÓGICOS EM CRIANÇAS E FILHOS DE PAIS SEPARADOS
Authors: Lopes Amanda Loucherlison Ferreira , Mesquita Luana Marques
Published: October 2023

O divórcio é um momento de ruptura um relacionamento de um casal sendo caracterizado muito das vezes com sentimentos negativos e envolve aspectos sociais, antropológicos e religiosos. Com isso se levanta a problemática: quais os impactos psicológicos em crianças filhos de pais separados ou divorciados? Para responder essa pergunta, foi proposto como objetivo principal e secundários:  compreender a importância da família no desenvolvimento da criança; apontar os impactos psicológicos em crianças filhos de pais separados ou divorciados; demonstrar o papel do psicólogo no processo de divórcio; documentar os impactos do divórcio na educação dos filhos. Com relação aos resultados o divórcio é o momento de quebra da dinâmica familiar trazendo impactos psicológicos para pais, e os filhos. Dentre os impactos estão diminuição rendimento escolar, e o surgimento de transtornos de ansiedade. Além disso, o psicólogo atua diretamente nos processos judiciais de guarda ao analisar a síndrome de alienação parental. Conclui-se então que o divórcio é um momento traumático para as crianças que o vivenciam necessitando, portanto, a intervenção do psicólogo com relação aos aspectos emocional, da vida escolar e no auxílio da Justiça.
Implementasi Budaya Religius Dalam Mendisiplinkan Peserta Didik SMP Muhammadiyah 3 Kota Bandung
Authors: Nurpujianti Cici , Mukhlishah  , Ibrohim Iim , Muhtadin  , Hernawati
Published: October 2023

Sekolah memiliki peran penting untuk dapat meminimalisir serta menanggulangi kenakalan remaja dengan meningkatkan dan memperkuat karakter disiplin peserta didik, melalui pembiasaan dan penerapan budaya beragama yang dilakukan di sekolah. Tujuan menjadikan peserta didik yang mempunyai kepribadian baik dengan menerapkan kedisiplinan. Maka dari itu, Pentingnya disiplin karena beberapa alasan, yaitu karena kesadaran diri, sehingga siswa berhasil dalam belajarnya. Tanpa disiplin yang baik, suasana sekolah menjadi kurang kondusif seperti peserta didik yang datang terlambat, aturan bahkan memberikan sanksi ketika peserta didik tidak disiplin. Sekolah dapat membiasakan norma-norma, nilai-nilai kehidupan dengan menerapkan kedisiplinan. Disiplin merupakan jalan bagi peserta didik dalam meraih kesuksesan dan berguna bagi masa depan. Penelitian ini bertujuan untuk mengetahui implementasi budaya keagamaan dalam mendisiplinkan peserta didik melalui: 1) Desain implementasi budaya keagamaan dalam mendisiplinkan peserta didik kelas 8 SMP Muhammadiyah 3 Kota Bandung 2) Implementasi budaya keagamaan dalan mendisiplinkan peserta didik kelas 3) Faktor pendukung dan penghambat implementasi budaya keagamaan dalam mendisiplinkan peserta didik, 4) Hasil implementasi budaya keagamaan dalam mendisiplinkan peserta didik kelas 8 SMP Muhammadiyah 3 Kota Bandung. Metode yang digunakan dalam penelitian ini adalah analisis deskriptif dengan pendekatan kualitatif. Pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa adanya suatu perubahan perilaku peserta didik setelah menerapkan budaya religius,
Peran Ekstrakulikuler Hizbul Wathon Pada Jiwa Kepemimpinan Siswa SMP Muhammadiyah 3 Kota Bandung
Authors: Kaniawati Imasdewi , Hendarriyadi  , Chadidjah Sitti , Ibrohim Iim , Hernawati Hernawati
Published: October 2023

Jiwa kepemimpinan merupakan salah satu topik yang selalu menarik untuk diteliti dan dikaji, karena paling banyak diamati sekaligus hal yang sedikit bisa dipahami. Yang menjadi masalah yaitu dinamika itu ke arah lebih baik atau malah mengalami kemunduran. Untuk mengatasi adanya kemunduran dibutuhkan upaya-upaya untuk mengantisipasinya, yaitu dengan adanya pendidikan kepemimpinan sejak dini. Fokus penelitian ini adalah latihan Hizbul Wathon dalam mengembangkan jiwa kepemimpinan melalui Latihan PBB, Tali-temali, Semafhore, Sandi morse dan Penjelajahan. Penelitian ini bertujuan untuk mengetahui: 1) Program ekstrakulikuler Hizbul Wathon Di SMP Muhammadiyah 3 Kota Bandung. 2) Mengetahui jiwa kepemimpinan siswa pada anggota Hizbul Wathon di SMP Muhammadiyah 3 Kota Bandung. 3) Hasil implementasi jiwa kepemimpinan siswa di SMP Muhammadiyah 3 Kota Bandung. Metode yang digunakan dalam penelitian ini adalah deskriptif analisis dengan pendekatan kualitatif. Pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa 1) kesimpulan Program ekstrakulikuler Hizbul Wathon kelas 8 SMP Muhammadiyah 3 Kota Bandung mencakup . a) Latihan PBB (pelaturan baris berbaris), b) Latihan tali-temali, c) Latihan semafhore d) latihan sandi morse, e) Latihan penjelajahan. 2) Jiwa kepemimpinan siswa kelas 8 SMP Muhammadiyah 3 Kota Bandung nampak baik. Hal tersebut dibentuk melalui pelaksanakan pelatihan PBB (pelaturan baris berbaris), Latihan tali temali, Latihan semafhore, Latihan sandi morse, dan Latihan penjelajahan. 3) Hasil implementasi jiwa kepemimpinan siswa kelas 8 SMP Muhammadiyah 3 Kota Bandung cukup baik. Hal tersebut ditunjukan dengan didapatkanya siswa di SMP Muhammadiyah 3 Kota Bandung yang setelah mengikuti pelatihan Hizbul Wathon lebih disiplin dalam memanfaatkan waktu, pelaksanaan pelatihan di sekolah dan luar sekolah lebih baik serta lebih menaati peraturan sekolah yang ada.
Pengaruh Model Discovery Learning Terhadap Kemampuan Kolaborasi Siswa Pada Mata Pelajaran Akidah Akhlak Kelas VIII Mts Cijawura Kota Bandung
Authors: Sopiah Siti , Hadiati Pujawardani Hani
Published: October 2023

Penelitian ini dilatar belakangi oleh kemampuan kolaborasi siswa yang masih tergolong rendah. Hal tersebut terlihat dari banyaknya siswa yang aktif hanya itu-itu saja, kurang mampu menyatukan pendapat, saling mengandalkan temannya untuk presentasi, dan sering memilah dalam menentukan anggota kelompok. Tujuan dalam penelitian ini yaitu, 1) untuk mengetahui model discovery learning kelas VIII di MTs Cijawura Kota Bandung 2) untuk mengetahui realitas kemampuan kolaborasi kelas VIII di MTs Cijawura Kota Bandung 3) untuk mengetahui pengaruh model discovery learning terhadap kemampuan kolaborasi siswa pada mata pelajaran akidah akhlak kelas VIII di MTs Cijawura Kota Bandung. Penelitian ini menggunakan pendekatan kuantitatif. Metode yang digunakan penelitian ini adalah analisis deskriptif. Populasi sampel adalah seluruh siswa kelas VIII di Mts Cijawura Kota Bandung yang berjumlah 75 siswa.data yang terkumpul dianalisis menggunakan analisis instrumen, uji asumsi klasik, uji statistik deskriptif, dan pengujian hipotesis uji t, dan analisis reagresi sederhana. Hasil dalam penelitian ini yakni 1) hasil analisis deskriptif diperoleh sebesar 3,60. Maka dapat disimpulkan bahwa penggunaan model discovery learning kelas VIII di MTs Cijawura Kota Bandung termasuk “baik”. 2) hasil analisis deskriptif diperoleh sebesar 3,46. Maka dapat disimpulkan bahwa realitas kemampuan kolaborasi kelas VIII di MTs Cijawura Kota Bandung termasuk “baik”. Model pembelajaran discovery learning berpengaruh signifikan terhadap kemampuan kolaborasi siswa dengan nilai signifikansi pada tabel coeffisiens sebesar 0,000 lebih kecil dari 0,05. Maka dapat disimpulkan bahwa model pembelajaran discovery learning dapat dijadikan sebagai salah satu alternatif pengembangan kemampuan kolaborasi.
Crush Syndrome Knowledge Levels of Nursing Students: An Intervention Study
Authors: ÖZPULAT Funda , TAŞDELEN BAŞ Melike , MOLU Birsel
Published: October 2023

This study had two objectives: (1) determining how much nursing students know about Crush syndrome and (2) using an intervention program to increase their knowledge level. This quasi-experimental pretest-posttest research was conducted between October 21 and December 31, 2021. The sample consisted of 43 third-grade nursing students taking the “Disaster Management and Nursing” course. The researchers designed a case and presented participants with an “Algorithm for the Medical Approach to the Wounded with Crush Syndrome” (AMAWCS). They asked all participants to mark the right approaches based on the algorithm. Participants had a significantly higher posttest CSKF score (24.61±.62) than the pretest CSKF score (21.67±3.01) (p ˂.001). Most participants stated that they had taken a course on crush syndrome before (86%). Participants who had taken a course on crush syndrome before had a significantly higher pretest and posttest CSKF score than those who had not (˂.001). The AMAWCS teaches nursing students about crush syndrome, related complications, and medical interventions. Our results show that algorithms can help nursing students learn what crush syndrome is and how to treat it. In this way, we can ensure high-quality nursing care to treat crush syndrome.
Çocuklarda Deri Muayenesi; Hemşirenin Rol ve Sorumlulukları
Authors: DEMİRCİ ECEVİT Esra , AYDIN ATEŞ Nuran
Published: October 2023

Deri tüm vücudumuzu kaplayan en geniş organımızdır. Yaşımızı ve sağlık durumumuzu yansıttığı gibi birçok hastalık konusunda bizlere ipuçları verebilir. Çocuklarda derinin dikkatli muayene edilmesi çok önemlidir ve çocukla ilgili hemşireye oldukça önemli ipuçları verir. Dikkatli ve bütüncül yapılan bir deri muayenesi çocuğun beslenme ve hidrasyon durumu, psikolojik durumu ve aile yapısı hakkında bizi bilgilendirir. Deri yapı ve fonksiyon olarak çocuklarda ve yetişkinlerde büyük benzerlik gösterse de yaş dönemlerine göre dikkat edilmesi gereken bazı farklılıklar ve noktalar vardır. Deri muayenesinde sisteme özgü öykü alınmalı ve ardından yine sisteme özgü fizik muayene yapılmalıdır. Derinin izlenmesi ve değerlendirilmesi hemşirelik mesleğinin yetki ve sorumlulukları kapsamında da belirtilmiştir. Aynı zamanda çocukluk çağı boyunca yaş dönemlerine göre görülen deri hastalıkları da değişkenlik göstermektedir. Hemşireler bu hastalıkların neler olduğunu, hangi belirti ve bulgular ile seyredebileceğini bilmeli ve aileleri yönlendirmelidir. Bu derleme pediatri hemşirelerinin yaş dönemlerine göre çocuklarda deri muayenesi yaparken dikkat etmeleri gereken noktalara, muayene tekniklerine ve çocuklarda sık görülen deri hastalıklarına güncel bir bakış açısı sunmaktadır.