bluuebunny/crossref_metadata_2025 huggingface dataset:
Degree of Fibrosis in Human Atrial Tissue Is Not the Hallmark Driving AF
Authors: S. Ramos Kennedy , Pool Lisa , van Schie Mathijs S. , Wijdeveld Leonoor F. J. M. , van der Does Willemijn F. B. , Baks Luciënne , Sultan H. M. Danish , van Wijk Stan W. , Bogers Ad J. J. C. , Verheule Sander , de Groot Natasja M. S. , Brundel Bianca J. J. M.
Published: January 2022

Background: The current paradigm is that fibrosis promotes electrophysiological disorders and drives atrial fibrillation (AF). In this current study, we investigated the relation between the degree of fibrosis in human atrial tissue samples of controls and patients in various stages of AF and the degree of electrophysiological abnormalities. Methods: The degree of fibrosis was measured in the atrial tissue and serum of patients in various stages of AF and the controls. Hereto, picrosirius and H&E staining were performed to quantify degree of total, endo-perimysial fibrosis, and cardiomyocyte diameter. Western blot quantified fibrosis markers: neural cell adhesion molecule, tissue inhibitor of metalloproteinase, lysyl oxidase, and α-smooth muscle actin. In serum, the ratio carboxyl-terminal telopeptide of collagen/matrix-metalloproteinase1 was determined. High-resolution epicardial mapping evaluated low-voltage areas and conduction abnormalities. Results: No significant differences were observed in the degree of fibrosis between the groups. Finally, no significant correlation—absolute nor spatial—was observed between all electrophysiological parameters and histological fibrosis markers. Conclusions: No differences in the degree of fibrosis were observed in patients from various stages of AF compared to the controls. Moreover, electrophysiological abnormalities did not correlate with any of the fibrosis markers. The findings indicate that fibrosis is not the hallmark of structural remodeling in AF.
Therapeutic Targeting of Intestinal Fibrosis in Crohn’s Disease
Authors: Santacroce Giovanni , Lenti Marco Vincenzo , Di Sabatino Antonio
Published: January 2022

Intestinal fibrosis is one of the most threatening complications of Crohn’s disease. It occurs in more than a third of patients with this condition, is associated with increased morbidity and mortality, and surgery often represents the only available therapeutic option. The mechanisms underlying intestinal fibrosis are partly known. Studies conducted so far have shown a relevant pathogenetic role played by mesenchymal cells (especially myofibroblasts), cytokines (e.g., transforming growth factor-β), growth factors, microRNAs, intestinal microbiome, matrix stiffness, and mesenteric adipocytes. Further studies are still necessary to elucidate all the mechanisms involved in intestinal fibrosis, so that targeted therapies can be developed. Although several pre-clinical studies have been conducted so far, no anti-fibrotic therapy is yet available to prevent or reverse intestinal fibrosis. The aim of this review is to provide an overview of the main therapeutic targets currently identified and the most promising anti-fibrotic therapies, which may be available in the near future.
Influence of ROCK Pathway Manipulation on the Actin Cytoskeleton Height
Authors: Grandy Carolin , Port Fabian , Pfeil Jonas , Gottschalk Kay-Eberhard
Published: January 2022

The actin cytoskeleton with its dynamic properties serves as the driving force for the movement and division of cells and gives the cell shape and structure. Disorders in the actin cytoskeleton occur in many diseases. Deeper understanding of its regulation is essential in order to better understand these biochemical processes. In our study, we use metal-induced energy transfer (MIET) as a tool to quantitatively examine the rarely considered third dimension of the actin cytoskeleton with nanometer accuracy. In particular, we investigate the influence of different drugs acting on the ROCK pathway on the three-dimensional actin organization. We find that cells treated with inhibitors have a lower actin height to the substrate while treatment with a stimulator for the ROCK pathway increases the actin height to the substrate, while the height of the membrane remains unchanged. This reveals the precise tuning of adhesion and cytoskeleton tension, which leads to a rich three-dimensional structural behaviour of the actin cytoskeleton. This finetuning is differentially affected by either inhibition or stimulation. The high axial resolution shows the importance of the precise finetuning of the actin cytoskeleton and the disturbed regulation of the ROCK pathway has a significant impact on the actin behavior in the z dimension.
Acknowledgment to Reviewers of ChemEngineering in 2021
Authors:   ChemEngineering Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Valence-, Dipole- and Quadropole-Bound Electronically Excited States of Closed-Shell Anions Formed by Deprotonation of Cyano- and Ethynyl-Disubstituted Polycyclic Aromatic Hydrocarbons
Authors: Strauss Marie E. , Santaloci Taylor J. , Fortenberry Ryan C.
Published: January 2022

Dicyano-functionalized benzene and naphthalene anion derivatives exhibit a relatively rich population of electronically excited states in stark contrast to many assumptions regarding the photophysics of anions in general. The present work has quantum chemically analyzed the potential electronically excited states of closed-shell anions created by replacing hydrogen atoms with valence-bound lone pairs in benzene and naphthalene difunctionalized with combinations of -CN and -C2H. Dicyanobenzene anion derivatives can exhibit dipole-bound excited states as long as the cyano groups are not in para position to one another. This also extends to cyanoethynylbenzene anions as well as deprotonated dicyano- and cyanoethynylnaphthalene anion derivatives. Diethynyl functionalization is less consistent. While large dipole moments are created in some cases for deprotonation on the -C2H group itself, the presence of electronically excited states beyond those that are dipole-bound is less consistent. Beyond these general trends, 2-dicyanonaphthalene-34 gives strong indication for exhibiting a quadrupole-bound excited state, and the 1-cyanoethynylnaphthalene-29 and -36 anion derivatives are shown to possess as many as two valence-bound excited states and one dipole-bound excited state. These photophysical properties may have an influence on regions where polycyclic aromatic hydrocarbons are known to exist such as in various astrochemical environments or even in combustion flames.
Acknowledgment to Reviewers of Chemistry in 2021
Authors:   Chemistry Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Design and Evaluation of a Competitive Phosphorescent Immunosensor for Aflatoxin M1 Quantification in Milk Samples Using Mn:ZnS Quantum Dots as Antibody Tags
Authors: Forcada Sergio , Sánchez-Visedo Adrián , Melendreras Candela , Menéndez-Miranda Mario , Costa-Fernández José M. , Royo Luis J. , Soldado Ana
Published: January 2022

Aflatoxin M1 (AFM1) is one of the most widespread aflatoxins that can be present in the milk of lactating mammals. It can cause carcinogenicity, mutagenesis, teratogenesis, genotoxicity and immunosuppression. The WHO recommends reducing the AFM1 concentration in food products, so the European Commission has set a maximum allowable limit of 0.05 µg L−1 in milk and its products. Thus, there is a need to develop new methodologies to satisfy the demand for reliable, cost-effective, robust and sensitive AFM1 routine controls. In the present work, a competitive phosphorescent immunosensor for AFM1 quantification in milk, based on antibody–antigen recognition and Mn:ZnS quantum dots (d-QDs) as photoluminescent labels, has been developed. Two different assay strategies based on the use of d-QDs as labels of secondary antibodies (direct assay), or of a derivative species of the antigen AFM1-Bovine Serum Albumin (indirect assay) were compared in terms of analytical performance for AFM1 quantification. The best analytical results were obtained with the immunoassay format that uses d-QDs as tags of secondary antibodies (direct assay), and said design was finally selected. The selected immunosensor provided a detection limit for AFM1 quantification of only 0.002 µg L−1, which greatly satisfied the maximum tolerable limit of AFM1 in milk of 0.05 µg L−1. The accuracy, calculated as recovery of AFM1 in fortified skimmed milk samples, ranged from 81 to 90%, with relative standard deviations from 3% to 14%. These results bring to light the good performance of such phosphorescent biosensors as simple and fast alternatives to conventional chromatographic analytical methods.
Mixed Oxime-Functionalized IL/16-s-16 Gemini Surfactants System: Physicochemical Study and Structural Transitions in the Presence of Promethazine as a Potential Chiral Pollutant
Authors: Pandya Subhashree Jayesh , Kapitanov Illia V. , Banjare Manoj Kumar , Behera Kamalakanta , Borovkov Victor , Ghosh Kallol K. , Karpichev Yevgen
Published: January 2022

The increasing concern about chiral pharmaceutical pollutants is connected to environmental contamination causing both chronic and acute harmful effects on living organisms. The design and application of sustainable surfactants in the remediation of polluted sites require knowledge of partitioning between surfactants and potential pollutants. The interfacial and thermodynamic properties of two gemini surfactants, namely, alkanediyi-α,ω-bis(dimethylhexadecyl ammonium bromide) (16-s-16, where s = 10, 12), were studied in the presence of the inherently biodegradable oxime-functionalized ionic liquid (IL) 4-((hydroxyimino)methyl)-1-(2-(octylamino)-2-oxoethyl)pyridin-1-ium bromide (4-PyC8) in an aqueous solution using surface tension, conductivity, fluorescence, FTIR and 1H NMR spectroscopic techniques. The conductivity, surface tension and fluorescence measurements indicated that the presence of the IL 4-PyC8 resulted in decreasing CMC and facilitated the aggregation process. The various thermodynamic parameters, interfacial properties, aggregation number and Stern–Volmer constant were also evaluated. The IL 4-PyC8-gemini interactions were studied using DLS, FTIR and NMR spectroscopic techniques. The hydrodynamic diameter of the gemini aggregates in the presence of promethazine (PMZ) as a potential chiral pollutant and the IL 4-PyC8 underwent a transition when the drug was added, from large aggregates (270 nm) to small micelles, which supported the gemini:IL 4-PyC8:promethazine interaction. The structural transitions in the presence of promethazine may be used for designing systems that are responsive to changes in size and shape of the aggregates as an analytical signal for selective detection and binding pollutants.
Maternal Singing but Not Speech Enhances Vagal Activity in Preterm Infants during Hospitalization: Preliminary Results
Authors: Filippa Manuela , Nardelli Mimma , Della Casa Elisa , Berardi Alberto , Picciolini Odoardo , Meloni Sara , Lunardi Clara , Cecchi Alessandra , Sansavini Alessandra , Corvaglia Luigi , Scilingo Enzo Pasquale , Ferrari Fabrizio ,   EVC Group
Published: January 2022

Background: Early parental interventions in the Neonatal Intensive Care Units (NICUs) have beneficial effects on preterm infants’ short and long-term outcomes. The aim of this study was to investigate the effects of Early Vocal Contact (EVC)—singing and speaking—on preterm infants’ vagal activity and autonomic nervous system (ANS) maturation. Methods: In this multi-center randomized clinical trial, twenty-four stable preterm infants, born at 25–32 weeks gestational age, were randomized to either the EVC group or control group, where mothers did not interact with the babies but observed their behavior. Heart Rate Variability (HRV) was acquired before intervention (pre-condition), during vocal contact, and after it (post condition). Results: No significant effect of the vocal contact, singing and speaking, was found in HRV when the intervention group was compared to the control group. However, a significant difference between the singing and the pre and post conditions, respectively, preceding and following the singing intervention, was found in the Low and High Frequency power nu, and in the low/high frequency features (p = 0.037). By contrast, no significant effect of the speaking was found. Conclusions: Maternal singing, but not speaking, enhances preterm infants’ vagal activity in the short-term, thus improving the ANS stability. Future analyses will investigate the effect of enhanced vagal activity on short and long-term developmental outcomes of preterm infants in the NICU.
Congenital Pseudarthrosis of the Clavicle in Children: A Systematic Review
Authors: Depaoli Alessandro , Zarantonello Paola , Gallone Giovanni , Di Gennaro Giovanni Luigi , Ferrari Daniele , Marchesini Reggiani Leonardo , Manca Aniello , Trisolino Giovanni
Published: January 2022

(1) Background: Congenital pseudoarthrosis of the clavicle is a rare condition due to the failure of the union process of the ossification nuclei of the clavicle. The aim of this study was to conduct a systematic review of relevant case series about the argument to find an up-to-date base of evidence for treatment choice. (2) Methods: an electronic literature research of Ovid, MEDLINE and the Cochrane Library databases was conducted, and articles were selected based on inclusion criteria. Demographic data, clinical features, treatment options, outcomes and complications were analyzed. (3) Results: 21 articles met the inclusion criteria, showing a poor overall study quality; 231 pediatric patients (240 clavicles) were analyzed. The condition was typically right sided, showed no sex predominance and no clear predisposing factors. 156 patients underwent surgical treatment, mainly open debridement and refresh of bony ends, fixation with pin or plate and bone graft, with a successful union rate of 87.4%. The nonunion rate was significantly higher in the allograft group (44.4%, p = 0.019). (4) Conclusions: this paper presents an updated systematic review about treatment of congenital pseudoarthrosis of the clavicle. We confirm the generally satisfactory results of surgery, demonstrating that successful union is achievable in 87.4% of cases with a prevalence of 15.7% of major complications. Nonetheless our results should be interpreted with caution due to several limitations.
Alterations of the Gut Microbiome Associated to Methane Metabolism in Mexican Children with Obesity
Authors: Murga-Garrido Sofía Magdalena , Orbe-Orihuela Yaneth Citlalli , Díaz-Benítez Cinthya Estefhany , Castañeda-Márquez Ana Cristina , Cornejo-Granados Fernanda , Ochoa-Leyva Adrian , Sanchez-Flores Alejandro , Cruz Miguel , Burguete-García Ana Isabel , Lagunas-Martínez Alfredo
Published: January 2022

Gut microbiota is associated with the development of metabolic disorders. To study its association with childhood obesity, we performed a cross-sectional study with 46 children (6–12 years old). We collected fecal samples, food-frequency questionnaires (FFQs), and anthropometric measurements. Shotgun metagenomics were used to obtain the microbial taxonomic diversity and metabolic potential. We identified two dietary profiles characterized by complex carbohydrates and proteins (pattern 1) and saturated fat and simple carbohydrates (pattern 2). We classified each participant into normal weight (NW) or overweight and obese (OWOB) using their body mass index (BMI) z-score. The ratio of Firmicutes/Bacteroidetes and alpha diversity were not different between the BMI groups. Genera contributing to beta diversity between NW and OWOB groups included Bacteroides rodentium, B. intestinalis, B. eggerthii, Methanobrevibacter smithii, Eubacterium sp., and Roseburia sp. B. rodentium was associated with lower BMI and dietary pattern 1 intake. Eubacterium sp. and Roseburia sp. were associated with BMI increments and high consumption of dietary pattern 2. Methane and energy metabolism were found enriched in under-represented KEGG pathways of NW group compared to OWOB. Complex dietary and microbiome interaction leads to metabolic differences during childhood, which should be elucidated to prevent metabolic diseases in adolescence and adulthood.
Changes in Suicide Rate and Characteristics According to Age of Suicide Attempters before and after COVID-19
Authors: Kim Min-Jung , Paek So-Hyun , Kwon Jae-Hyun , Park Soo-Hyun , Chung Hyun-Jung , Byun Young-Hoon
Published: January 2022

This study aims to identify age-related suicide-related factors and changes in suicide rate before and after the onset of the COVID-19 pandemic. Methods: From 2018 to 2020, the patients who presented to the ED of a university hospital with a suicide attempt were classified into adolescents (≤18 years), adults (19–65 years), and elderly (>65 years), and the visits were grouped into before and after COVID-19. Results: There were 853 visits before and 388 visits after COVID-19, and the results showed that the number of adolescent and adult suicide patients increased immediately after the pandemic, but the overall trend did not show a significant difference from before the pandemic. In the adolescents, the ratio of male patients increased, interpersonal and school-related motivations decreased, the poisoning and cutting methods of suicide were more common, and hospitalization admissions increased. Among the elderly, the ratio of female patients increased, the number of single patients and patients without previous psychiatric problems increased, the motives for physical illness and death of people around increased, the falling and hanging methods of suicide were more common, and hospitalization admissions and deaths increased. Conclusion: The impact of COVID-19 on suicide rates and suicide-related factors varies by age group. This finding requires different approaches and methods to suicide prevention based on age.
The Length of the Transition Zone in Patients with Rectosigmoid Hirschsprung Disease
Authors: Tomuschat Christian , Mietzsch Stefan , Dwertmann-Rico Sebastian , Clauditz Till , Schaefer Hansjoerg , Reinshagen Konrad
Published: January 2022

Background: The transition zone (TZ) is defined by specific histological findings in patients with Hirschsprung Disease (HSCR). HSCR treatment includes surgical removal of the aganglionic zone (AZ). During the pull-through procedure, it is critical to resect the TZ. Given the TZ’s wide histological heterogeneity, we wanted to know how extensive the histological transition zone is. Methods: A retrospective study of patients who had pull-through surgery for rectosigmoid HSCR between January 2010 and December 2020 was carried out. Demographics, length of TZ and AZ, age and symptoms upon presentation, and complications after surgery were also obtained. Results: The inclusion criteria were met by 50 patients. The mean age of all patients was 10 months (0.1–107.5 months), with a mean age at pull-through of 16.3 months (3–112 months). Thirty-one out of fifty patients (62%) received primary laparoscopic endorectal pull-through surgery (LEPT). The average TZ length of all patients was 2.6 cm (0–10 cm), and the AZ length was 9.6 cm (1–30 cm). The length of the AZ and TZ were shown to have no correlation (r² = 0.237). Conclusions: The current study found that the mean length of the TZ in individuals with rectosigmoid HSCR is less than 5 cm in most cases and has no correlation with the length of the AZ.
Obsessive-Compulsive Disorder in PANS/PANDAS in Children: In Search of a Qualified Treatment—A Systematic Review and Metanalysis
Authors: Cocuzza Salvatore , Maniaci Antonino , La Mantia Ignazio , Nocera Francesco , Caruso Daniela , Caruso Sebastiano , Iannella Giannicola , Vicini Claudio , Privitera Elio , Lechien Jerome Rene , Pavone Piero
Published: January 2022

Background: Several treatment options have been proposed for pediatric acute-onset neuropsychiatric syndrome/pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANS/PANDAS). Still, no clear therapeutic protocol has been recognized to prevent these neuropsychiatric diseases. The study aims to report on the literature evidence and different treatment strategies related to these disorders. Methods: We analyzed the last 20 years’ English language literature and performed a comprehensive review of the PANS/PANDAS treatment, including studies reporting OCD outcomes post-treatment follow-up. Results: We covered 11 articles in our systematic literature review for a total of 473 patients, of which four studies included 129 surgical subjects and seven papers with 326 medically treated patients. Pooled outcomes analysis, surgical and medical treatment reported an OCD reduction, but no statistical significance was obtained (p < 0.05 for both). Conclusions: Surgical therapy in selected patients can lead to promising results, although further evidence is needed. On the other hand, the role of medical therapy remains controversial, often due to the lack of univocal curative protocols and variable responses depending on the drug used and the timing of administration. Therefore, further investigations are necessary to clarify the most appropriate therapeutic procedure.
The Young Parenting Inventory (YPI-R3), and the Baumrind, Maccoby and Martin Parenting Model: Finding Common Ground
Authors: Louis John Philip
Published: January 2022

The parenting typology of Baumrind, Maccoby and Martin is based on variations in warmth and control and consists of three negative parenting styles labelled authoritarian, neglectful, and permissive. This parenting typology is based on normal variations of parenting but did not include dimensions arising from deviant parenting (e.g., abuse and neglect). A parenting typology has emerged based on the schema therapy model through the development of the Young Parent Inventory (YPI-R3), which represents a fuller range of maladaptive parenting spanning the deviant to normal range of the parenting continuum. Using six international, community, nonclinical samples with separate ratings for mothers and fathers from the USA, n = 259, 281; South Africa, n = 318, 372; Nigeria, n = 328, 344; India, n = 277, 289; Singapore, n = 592, 628; and Malaysia, n = 222, 229, results showed that the best second order higher factor solution of the ten YPI-R3 subscales was a three factor solution that runs parallel to, and resembles, the three negative parenting styles of Baumrind, Macobby and Martin. This factor structure was also shown to be a consistent and cross-culturally acceptable model among the countries from which the samples were drawn. The resemblance and implications of both parenting models were discussed.
Acknowledgment to Reviewers of Clean Technologies in 2021
Authors:   Clean Technologies Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Acknowledgment to Reviewers of Corrosion and Materials Degradation (CMD) in 2021
Authors:   CMD Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Geomorphological Evolution of the Andaman Sea Offshore Phang Nga Province (Thailand) during the Holocene: An Example for a Sediment Starving Shelf
Authors: Feldens Peter , Schwarzer Klaus , Sakuna-Schwartz Daroonwan , Khokiattiwong Somkiat
Published: January 2022

Understanding the development of shallow seas is essential, as they provide a major environmental and economic resource. An investigation of the Holocene development and the present conditions of the Andaman Sea shelf was carried out based on hydroacoustic surveys and sedimentological sampling. The results show that the relative sea level in the offshore Phang Nga province (Thailand) was at a present-day water depth of approximately 63 m at 13 cal ka BP. This agrees with the sea level development of the Sunda Shelf. Since that time, the Andaman Sea continental shelf developed as a sediment-starved environment, with less than 2 m thickness of sediment deposited during the Holocene on the crystalline basement over large areas between 60 m and 20 m water depth. Between 28 and 17 m water depth, a series of moribund asymmetrical sand ridges exist. These ridges were formed around 9.0 ka cal BP. They strike oblique to the coastline. On the seaward side of the sand ridges, small NW-SE directed submarine dunefields developed, shaped by monsoon-induced currents.
Investigation of Deterioration for Large Outdoor Iron Statues Relics: A Case Research of Chairman MAO Iron Statue in Qinghai, China
Authors: Mai Bingjie , Li Jiaxin , Zhang Ying , Feng Xue , Wang Juanli , Li Yuhu , Chao Xiaolian , Cao Jing
Published: January 2022

In this study, the Chairman MAO iron statue in Qinghai, China was analyzed via multi-analytical methodology, including polarizing microscope, SEM-EDS, metallographic analysis, high-resolution X-ray diffractometer, ion chromatographic analysis, silver nitrate titration detection in rust samples. The iron cultural relics are affected by factors such as their chemical composition, metallographic structure and surface characteristics, casting process, and natural storage environment. Although the corrosion rate is different, the corrosion is inevitable. With the corroborative evidence derived from the above analyses, it could be determined that the long-term preservation of cast iron statues in outdoor natural environments is prone to oxidation and corrosion, which due to the poor air circulation inside the statue of Chairman Mao Zedong, the humidity is significantly higher than that of the outside. In addition, due to the large temperature difference between day and night in this area, the condensed water is easy to form, causing the inner cavity of the statue and the welding parts to be rusted particularly seriously by the electrochemical corrosion and chemical corrosion. Compared with single chemical corrosion, electrochemical reaction can greatly accelerate the corrosion of iron. This result provided important scientific basis onto the production crafts of the precious casting, and the correlation between environment and deterioration for large outdoor iron relics, contributing to the conservators to make informed decisions on restoration.
Potential Applications of Geopolymer Cement-Based Composite as Self-Cleaning Coating: A Review
Authors: Zailan Siti Norsaffirah , Mahmed Norsuria , Abdullah Mohd Mustafa Al Bakri , Rahim Shayfull Zamree Abd , Halin Dewi Suriyani Che , Sandu Andrei Victor , Vizureanu Petrica , Yahya Zarina
Published: January 2022

Nowadays, concepts of self-cleaning have received great attention in construction building materials. Self-cleaning with the presence of photocatalyst has been applied in building materials to overcome the problem of building surfaces becoming dirty after exposure for a long time in highly polluted areas. To date, the concept of green blending materials has led to the development of a new binding material for green materials, which is geopolymer with an addition of photocatalyst. This review focused on the development of conventional self-cleaning paste, including the method of preparation and the impact of adding photocatalyst on physical and mechanical properties. However, although self-cleaning has been widely applied in conventional cement paste, its applications in geopolymers are still in the early stages of development and require more research. Therefore, this paper also intended to review the current knowledge on properties of geopolymer cement-based composite and its potential to be applied as a self-cleaning coating.
A New Type of Coating Brush Plating Solution and Its Application Performance
Authors: Meng Zhifei , Zheng Kewang , Huang Chaofan , Li Wei , Qin Caiqin
Published: January 2022

A new type of coating brush plating solutioncontaining stannous sulfate and potassium pyrophosphate was prepared by solution mixing method.Its structures, physicochemical properties, and the application effect in power equipment contact were also investigated by electrochemical workstation, X-ray photoelectron spectroscopy (XPS), scanning electron microsco (SEM), Mapping, and infrared thermometer. The results showed that the tin coating has good adaptability to the ambient temperature and good adhesion with the copper substrate. Cerium nitrate was evenly distributed over the tin plating layer, reduced the crystal refinement of tin and lead to a uniform distribution of microdefects. When the cerium nitrate content, the amount of additives, the amount of complex agent, and the number of brush plating operations are 0.1%, 10.0%, 8.0%, and 5 times, respectively, the tin plating layer has the best electrochemical performance. For application, the damaged contacts of power equipment can fully meet the demand of power use after being treated by the new brush plating solution.
Enhancing the Corrosion Resistance of Low Pressure Cold Sprayed Metal Matrix Composite Coatings on AZ31B Mg Alloy through Friction Stir Processing
Authors: Mohankumar Ashokkumar , Duraisamy Thirumalaikumarasamy , Chidambaramseshadri Ramachandran , Pattabi Thirumal , Ranganathan Sathiyamoorthy , Kaliyamoorthy Murugan , Balachandran Guruprasad , Sampathkumar Deepak , Rajendran Pradeep Raj
Published: January 2022

To improve the corrosion resistance of Mg alloy, Al alloy/alumina metal matrix composite (MMC) coatings were formed by low pressure cold spraying (LPCS) technology followed by post friction stir processing. The phase structure, microstructure, and corrosion properties of the cold-sprayed metal matrix composite coatings before and after friction stir processing were investigated. The effect of the friction stir process (FSP) on the corrosion characteristics of MMC coatings at 3.5 weight percent of NaCl solution was explored using a Tafel polarisation plot. Microstructural studies were examined to investigate the electrochemical behaviour of the cold spray (CS) and FSPed MMC coatings. The results demonstrated that an enhancement in corrosion protection of the MMC deposits occurred at the 1st and 2nd runs of FSP, with superior corrosion performance observed at the 2nd run of FSP. The enhanced surface state is the primary enhancement mechanism of the electrochemical properties of the FSPed MMC coatings. For the higher run of FSP (3rd run), the electrochemical performance of the specimens was lower owing to the amalgamate action of the enhanced surface state with the aggravated interface of interior deposits.
Drug-Releasing Gelatin Coating Reinforced with Calcium Titanate Formed on Ti–6Al–4V Alloy Designed for Osteoporosis Bone Repair
Authors: Yamaguchi Seiji , Akeda Koji , Shintani Seine A. , Sudo Akihiro , Matsushita Tomiharu
Published: January 2022

Ti–6Al–4V alloy has been widely used in the orthopedic and dental fields owing to its high mechanical strength and biocompatibility. However, this alloy has a poor bone-bonding capacity, and its implantation often causes loosening. Osteoporosis increases with the aging of the population, and bisphosphonate drugs such as alendronate and minodronate (MA) are used for the medical treatment. Reliable and multifunctional implants showing both bone bonding and drug releasing functions are desired. In this study, we developed a novel organic-inorganic composite layer consisting of MA-containing gelatin and calcium-deficient calcium titanate (cd–CT) with high bone-bonding and scratch resistance on Ti–6Al–4V alloy. The alloy with the composite layer formed apatite within 7 days in a simulated body fluid and exhibited high scratch resistance of an approximately 50 mN, attributable to interlocking with cd ± CT. Although the gelatin layer almost completely dissolved in phosphate-buffered saline within 6 h, its dissolution rate was significantly suppressed by a subsequent thermal crosslinking treatment. The released MA was estimated at more than 0.10 μmol/L after 7 days. It is expected that the Ti alloy with the MA-containing gelatin and cd–CT composite layer will be useful for the treatment of osteoporosis bone.
Magnetron Sputter-Deposited β-Ga2O3 Films on c-Sapphire Substrate: Effect of Rapid Thermal Annealing Temperature on Crystalline Quality
Authors: Pech Sakal , Kim Sara , Kim Nam-Hoon
Published: January 2022

Gallium oxide (Ga2O3) is a semiconductor with a wide bandgap of ~5.0 eV and large breakdown voltages (>8 MV·cm−1). Among the crystal phases of Ga2O3, the monoclinic β-Ga2O3 is well known to be suitable for many device applications because of its chemical and thermal stability. The crystalline quality of polycrystalline β-Ga2O3 films on c-plane sapphire substrates was studied by rapid thermal annealing (RTA) following magnetron sputtering deposition at room temperature. Polycrystalline β-Ga2O3 films are relatively simple to prepare; however, their crystalline quality needs enhancement. The β-phase was achieved at 900 °C with a crystallite size and d-spacing of 26.02 and 0.2350 nm, respectively, when a mixture of ε- and β-phases was observed at temperatures up to 800 °C. The strain was released in the annealed Ga2O3 films at 900 °C; however, the clear and uniform orientation was not perfect because of the increased oxygen vacancy in the film at that temperature. The improved polycrystalline β-Ga2O3 films with dominant (−402)-oriented crystals were obtained at 900 °C for 45 min under a N2 gas atmosphere.
Chitin Nanocrystals: Environmentally Friendly Materials for the Development of Bioactive Films
Authors: Muñoz-Núñez Carolina , Fernández-García Marta , Muñoz-Bonilla Alexandra
Published: January 2022

Biobased nanomaterials have gained growing interest in recent years for the sustainable development of composite films and coatings, providing new opportunities and high-performance products. In particular, chitin and cellulose nanocrystals offer an attractive combination of properties, including a rod shape, dispersibility, outstanding surface properties, and mechanical and barrier properties, which make these nanomaterials excellent candidates for sustainable reinforcing materials. Until now, most of the research has been focused on cellulose nanomaterials; however, in the last few years, chitin nanocrystals (ChNCs) have gained more interest, especially for biomedical applications. Due to their biological properties, such as high biocompatibility, biodegradability, and antibacterial and antioxidant properties, as well as their superior adhesive properties and promotion of cell proliferation, chitin nanocrystals have emerged as valuable components of composite biomaterials and bioactive materials. This review attempts to provide an overview of the use of chitin nanocrystals for the development of bioactive composite films in biomedical and packaging systems.
Study on the Performance Impact of Introducing an InN Buffer Layer at Various Deposition Temperatures on InN Film Grown by ECR-PEMOCVD on Free-Standing Diamond Substrate
Authors: Wang Shuaijie , Guan Xin , Liu Shu , Zhang Dong
Published: January 2022

In this study, InN films are grown at a relatively low temperature by electron cyclotron resonance plasma-enhanced metal organic chemical vapor deposition (ECR-PEMOCVD) on free-standing diamond substrates. Due to the high lattice mismatch rate between InN film and the free-standing diamond substrate, the function of a buffer layer is to build a bridge between the substrate and film to reduce the lattice mismatch between them. Therefore, here, we study the performance impact of introducing an InN buffer layer at various deposition temperatures and explore the optimal buffer layer deposition temperature used to grow relatively high-quality InN films. The experimental results show that when an InN buffer layer is introduced at a deposition temperature of 100 °C, the growth direction of the InN film is perpendicular to the substrate with a high c-axis preferred orientation, the roughness of the surface is minimal, and the particle sizes are consistent with growth in the same direction. Additionally, the carrier mobility is highest, and the carrier concentration is lowest compared with other conditions.
Acknowledgment to Reviewers of Colloids and Interfaces in 2021
Authors:   Colloids and Interfaces Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Hexatetra-Carbon: A Novel Two-Dimensional Semiconductor Allotrope of Carbon
Authors: Naseri Mosayeb , Jalilian Jaafar , Salahub Dennis R. , Lourenço Maicon Pierre , Rezaei Ghasem
Published: January 2022

Employing first-principles calculations based on density functional theory (DFT), we designed a novel two-dimensional (2D) elemental monolayer allotrope of carbon called hexatetra-carbon. In the hexatetra-carbon structure, each carbon atom bonds with its four neighboring atoms in a 2D double layer crystal structure, which is formed by a network of carbon hexagonal prisms. Based on our calculations, it is found that hexatetra-carbon exhibits a good structural stability as confirmed by its rather high calculated cohesive energy −6.86 eV/atom, and the absence of imaginary phonon modes in its phonon dispersion spectra. Moreover, compared with its hexagonal counterpart, i.e., graphene, which is a gapless material, our designed hexatetra-carbon is a semiconductor with an indirect band gap of 2.20 eV. Furthermore, with a deeper look at the hexatetra-carbon, one finds that this novel monolayer may be obtained from bilayer graphene under external mechanical strain conditions. As a semiconductor with a moderate band gap in the visible light range, once synthesized, hexatetra-carbon would show promising applications in new opto-electronics technologies.
Analytic Solution to the Piecewise Linear Interface Construction Problem and Its Application in Curvature Calculation for Volume-of-Fluid Simulation Codes
Authors: Lehmann Moritz , Gekle Stephan
Published: January 2022

The plane–cube intersection problem has been discussed in the literature since 1984 and iterative solutions to it have been used as part of piecewise linear interface construction (PLIC) in computational fluid dynamics simulation codes ever since. In many cases, PLIC is the bottleneck of these simulations regarding computing time, so a faster analytic solution to the plane–cube intersection would greatly reduce the computing time for such simulations. We derive an analytic solution for all intersection cases and compare it to the previous solution from Scardovelli and Zaleski (Scardovelli, R.; Zaleski, S. Analytical relations connecting linear interfaces and volume fractions in rectangular grids. J. Comput. Phys.2000, 164, 228–237), which we further improve to include edge cases and micro-optimize to reduce arithmetic operations and branching. We then extend our comparison regarding computing time and accuracy to include two different iterative solutions as well. We find that the best choice depends on the employed hardware platform: on the CPU, Newton–Raphson is fastest with compiler optimization enabled, while analytic solutions perform better than iterative solutions without. On the GPU, the fastest method is our optimized version of the analytic SZ solution. We finally provide details on one of the applications of PLIC—curvature calculation for the Volume-of-Fluid model used for free surface fluid simulations in combination with the lattice Boltzmann method.
Acknowledgment to Reviewers of Computers in 2021
Authors:   Computers Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Enriching Mobile Learning Software with Interactive Activities and Motivational Feedback for Advancing Users’ High-Level Cognitive Skills
Authors: Troussas Christos , Krouska Akrivi , Sgouropoulou Cleo
Published: January 2022

Mobile learning is a promising form of digital education to access learning content through modern handheld devices. Through mobile learning, students can learn using smartphones, connected to the Internet, without having restrictions posed by time and place. However, such environments should be enriched with sophisticated techniques so that the learners can achieve their learning goals and have an optimized learning experience. To this direction, in this paper, presents a mobile learning software which delivers interactive activities and motivational feedback to learners with the aim of advancing their higher level cognitive skills. In more detail, the mobile application employs two theories, namely Bloom’s taxonomy and the taxonomy of intrinsic motivations by Malone and Lepper. Bloom’s taxonomy is used for the design of interactive activities that belong to varying levels of complexity, i.e., remembering, understanding, applying, analyzing, evaluating, and creating. Concerning motivational feedback, the taxonomy of intrinsic motivations by Malone and Lepper is used, which identifies four major factors, namely challenge, curiosity, control, and fantasy, and renders the learning environment intrinsically motivating. As a testbed for our research, the presented mobile learning system was designed for the teaching of a primary school course; however, the incorporated taxonomies could be adapted to the tutoring of any course. The mobile application was evaluated by school students with very promising results.
Toward an Automated-Algebra Framework for High Orders in the Virial Expansion of Quantum Matter
Authors: Czejdo Aleks J. , Drut Joaquin E. , Hou Yaqi , Morrell Kaitlyn J.
Published: January 2022

The virial expansion provides a non-perturbative view into the thermodynamics of quantum many-body systems in dilute regimes. While powerful, the expansion is challenging as calculating its coefficients at each order n requires analyzing (if not solving) the quantum n-body problem. In this work, we present a comprehensive review of automated algebra methods, which we developed to calculate high-order virial coefficients. The methods are computational but non-stochastic, thus avoiding statistical effects; they are also for the most part analytic, not numerical, and amenable to massively parallel computer architectures. We show formalism and results for coefficients characterizing the thermodynamics (pressure, density, energy, static susceptibilities) of homogeneous and harmonically trapped systems and explain how to generalize them to other observables such as the momentum distribution, Tan contact, and the structure factor.
COVID-19 Outcomes in Patients Hospitalised with Acute Myocardial Infarction (AMI): A Protocol for Systematic Review and Meta-Analysis
Authors: Shaw Peter , Senguttuvan Nagendra Boopathy , Raymond Greg , Sankar Srivarshini , Mukherjee Anirban Goutam , Kunale Milind , Kodiveri Muthukaliannan Gothandam , Baxi Siddhartha , Mani Ravishankar Ram , Rajagopal Mogana , Samiappan Suja , Krishnan Sunil , Jayaraj Rama
Published: January 2022

Background: Patients with cardiovascular disease and risk factors for cardiovascular illness are more likely to acquire severe 2019 novel coronavirus (2019-nCoV) infection (COVID-19). COVID-19 infection is more common in patients with cardiovascular illness, and they are more likely to develop severe symptoms. Nevertheless, whether COVID-19 patients are more likely to develop cardiovascular disorders such as acute myocardial infarction (AMI) is still up for debate. Methods: We will follow the preferred reporting items for systematic review and meta-analysis (PRISMA) to report our final study, including a systematic search of the bibliographic database using the appropriate combination of search terms or keywords. The choice of search terms is discussed in more detail later in this paper. The obtained results will be screened, and the data extracted from the studies selected for systematic review will be based on the predefined inclusion and exclusion criteria. Using the obtained data, we will then perform the associated Meta-analysis to generate the forest plot (pooled estimated effect size Hazard Ratio (HR) and 95% Confidence Intervals (CI) values) using the random-effects model. Any publication bias will be assessed using the funnel plot symmetry, Orwin and Classic Fail-Safe N Test and Begg and Mazumdar Rank Correlation Test and Egger’s Test of the intercept. In cases where insufficient data occur, we will also perform a qualitative review. Discussion: This systematic review will explore COVID-19 clinical outcomes, especially survival in patients hospitalised with Acute Myocardial Infarction, by utilising a collection of previously published data on hospitalised COVID-19 patients and Myocardial Infarction. Highlighting these prognostic survival analyses of COVID-19 patients with AMI will have significant clinical implications by allowing for better overall treatment strategies and patient survival estimates by offering clinicians a method of quantitatively analysing the pattern of COVID-19 cardiac complications.
A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19
Authors: Khataniar Ankita , Pathak Upasana , Rajkhowa Sanchaita , Jha Anupam Nath
Published: January 2022

Drug repurposing is a more inexpensive and shorter approach than the traditional drug discovery and development process. The concept of identifying a potent molecule from a library of pre-existing molecules or an already approved drug has become a go-to tactic to accelerate the identification of drugs that can prevent COVID-19. This seemingly uncontrollable disease is caused by SARS-CoV-2. It is a novel virus of the Betacoronavirus genus, exhibiting similarities to the previously reported SAR-CoV genome structure and viral pathogenesis. The emergence of SARS-CoV-2 and the rapid outbreak of COVID-19 have resulted in a global pandemic. Researchers are hard-pressed to develop new drugs for total containment of the disease, thus making the cost-effective drug repurposing a much more feasible approach. Therefore, the current review attempts to collate both the experimental and computational drug repurposing strategies that have been utilized against significant drug targets of SARS-CoV-2. Along with the strategies, the available druggable targets shall also be discussed. However, the occurrence of frequent recombination of the viral genome and time-bound primary analysis, resulting in insignificant data, are two major challenges that drug repurposing still faces.
Impregnating Compound for Cement-Concrete Road Pavement
Authors: Lukpanov Rauan , Dyusembinov Duman , Shakhmov Zhanbolat , Tsygulov Denis , Aibuldinov Yelaman , Vatin Nikolai Ivanovich
Published: January 2022

The paper proposes an impregnation composition for cement concrete roads used as an ice-phobic coating. The composition has been made based on keratin-containing components derived from animal waste with the addition of water-soluble polymers. The main parameter of serviceability of the coating impregnated with the developed composition was assessing the adhesion resistance of ice crust to concrete under the influence of mechanical loads. For this purpose, tests of big specimens (surface area 1925 cm2) in laboratory conditions with application of vibration and impact loads and modelling of thermal stresses were conducted. The test results showed the effectiveness of the ice-coating, as in all experiments, the uncoated specimens showed a greater resistance of the ice crust to mechanical stresses. An additional evaluation parameter was comparing the water absorption capacity of coated and uncoated concrete. The test results showed a significant difference in the water absorption capacity of the uncoated specimens, exceeding the coated specimens by 47%. Due to the results obtained, it will be possible to use the impregnation compound effectively to improve the ice resistance of cement concrete coatings.