bluuebunny/crossref_metadata_2025 huggingface dataset:
DIFERENTES ABORDAGENS TERAPÊUTICAS PARA HIPOMINERALIZAÇÃO MOLAR INCISIVO: RELATO DE CASO
Authors: Ramos Adriele , Magari Maira M.P. , Manfron Ana Tulio , Bettega Patrícia Vida Cassi , Fatturi Aluhê Lopes
Published: July 2023

Introdução: A hipomineralização molar incisivo (HMI) é uma alteração disfuncional na qualidade da estrutura do esmalte, afetando molares e incisivos permanentes. Essa disfunção pode ser classificada em diferentes severidades, sendo elas; leve, moderada e severa, tendo diferentes formas de tratamento, como, verniz fluoretado, cimento de ionômero de vidro e resina composta. Objetivo: Objetivo desse trabalho é relatar um caso clínico com abordagens terapêuticas, utilizando CIV quimicamente e fotoativado e verniz fluoretado fotoativado para intervenção da HMI. Relato do caso: O paciente procurou atendimento com queixa de sensibilidade dentária, para obter diagnóstico da causa da sensibilidade foi realizado anamnese complementada pelo exame clínico e radiográfico, nos quais se observaram HMI leve (somente opacidade) nos incisivos centrais inferiores e primeiros molares permanentes superiores e HMI severa (com perda de estrutura) nos primeiros molares permanentes inferiores. Os dentes acometidos por HMI severa foram restaurados com cimento ionômero de vidro através da técnica de restauração atraumática, e os dentes acometido por HMI leve foram remineralizados através de aplicação de verniz de flúor fotopolimerizavel. Considerações finais: Foi possível observar que a abordagem terapêutica foi eficiente na diminuição sensibilidade dentária relatada pelo paciente.
Fieldwork through Filmmaking: Listening to Narrative Medicine in “Tåhdong Marianas”
Authors: Gumataotao Andrew
Published: July 2023

In-person interactions were drastically altered in the unincorporated territory island of Guåhan (Guam) and the Commonwealth of the Northern Mariana Islands during the height of the COVID-19 pandemic in 2020. This article seeks to investigate how lålai (CHamoru chant) and music making are resurgent forms of sound-based cultural practices that can be understood as “narrative medicine.” The latter has the potential to be a model for musical sensemaking, whereby Indigenous storytelling maintains connections among kin and heals from colonial trauma. Critically reflecting on a community grant film project entitled, “Tåhdong Marianas: Storytelling Across the Marianas,” I explore how a young group of Indigenous CHamorus use the medium of film to adapt to the situation of COVID-19 while calling into question conventional parameters of fieldwork. I analyze how the privileging of work done by and for Indigenous people actively foregrounds the sonic potential of narrative medicine by focusing on the sensory experiences of island peoples to music in ways that undo the epistemic violence of Indigenous knowledge erasure and extraction.
PENGARUH KOMPENSASI DAN KECERDASAN EMOSIONAL TERHADAP PRODUKTIVITAS KERJA KARYAWAN PT. INDOMOBIL FINANCE INDONESIA CABANG KENDARI
Authors: Reski Yunus  , Zainuddin Saenong  , La Ode Sabaruddin
Published: July 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis: (1) Pengaruh Kompensasi dan Kecerdasan Emosional Terhadap Produktivitas Kerja Karyawan Pada PT. Indomobil Finance Indonesia Cabang Kendari; (2) Pengaruh Kompensasi Terhadap Produktivitas Kerja Karyawan Pada PT. Indomobil Finance Indonesia Cabang Kendari, (3) Pengaruh Kecerdasan Emosional Terhadap Produktivitas Kerja Karyawan Pada PT. Indomobil Finance Indonesia Cabang Kendari.

            Hasil penelitian ini menyimpulkan bahwa: (1) Kompensasi dan Kecerdasan Emosionalberpengaruh positif dan signifikan terhadap Produktivitas Kerja Karyawan; (2) Kompensasi berpengaruh positif dan signifikan terhadap Produktivitas Kerja Karyawan; (3) Kecerdasan Emosional berpengaruh positif dan signifikan terhadap Produktivitas Kerja Karyawan.
ANALISIS STRATEGI PROMOTION MIX DALAM MENINGKATKAN OMZET PENJUALAN RUMAH PADA PT. SHIFA ISTHIN NEISYA KENDARI
Authors: Miftahul Janna  , Nasrul  , Rahmatia
Published: July 2023

Penelitian ini bertujuan untuk Mengetahui dan Menganalisis Strategi Promotion Mix (Advertising, Personal Selling, Sales Promotion, Publicity) dalam meningkatkan omzet penjualan rumah pada PT. Shifa Isthin Neisya Kendari. Penelitian ini dirancang sebagai penelitian kualitatif dengan objek penelitian pada strategi promotion mix dan omzet penjualan yang digunakan oleh PT. Shifa Isthin Neisya Kendari. Teknik analisis data yang digunakan dalam penelitian ini menggunakan metode analisis deskriptif kualitatif dengan menggambarkan sifat dan keadaan subyek penelitian atau menganalisis data dengan data yang terkumpul. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa strategi promotion mix (advertising, personal selling, sales promotion dan publisitas) yang digunakan PT. Shifa Isthin Neisya Kendari dapat meningkatkan penjualan. Promosi yang paling efektif digunakan yaitu periklanan yang menggunakan sosial media.
Pengetahuan Ibu tentang Imunisasi Dasar Balita di Desa Bama Kecamatan Pagelaran Kabupaten Pandeglang Tahun 2020
Authors: Setianingsih Lilis Zuniawati , Halimatusyadiah Leni , Octavia Rina
Published: July 2023

Imunisasi merupakan salah satu upaya untuk meningkatkan kekebalan tubuh dan pemberantasan penyakit menular. Angka kematian bayi dan balita yang tinggi di Indonesia menyebabkan turunnya derajat kesehatan masyarakat, salah satu upaya untuk mengatasi masalah ini adalah program pemberian imunisasi dasar bagi bayi dan balita secara lengkap. Namun program ini masih mengalami hambatan, yaitu penolakan dari orang tua. Penolakan orang tua dalam pemberian imunisasi ini dikarenakan anggapan yang salah yang berkembang di masyarakat tentang imunisasi, tingkat pengetahuan yang rendah, dan kesadaran yang kurang terhadap imunisasi. Tujuan penelitian ini memberikan karakteristik gambaran pengetahuan ibu tentang imunisasi dasar balita. Penelitian ini merupakan penelitian kuantitatif dengan desain deskriptif survey. Sampel yang digunakan sebanyak 88 responden yang diambil dengan teknik purposive sampling. Hasil penelitian menunjukkan ibu yang memiliki pengetahuan baik sebesar 62,5% dan yang memiliki pengetahuan kurang sebesar 37,5%. Kesimpulan dari penelitian ini yaitu sebagian besar ibu memiliki pengetahuan baik tentang imunisasi dasar balita, dan diharapkan pengetahuan yang baik ini dapat menunjang status imunisasi yang baik untuk anak.
Przegląd antykonsumenckich praktyk rynkowych dotyczących usług finansowych w świetle decyzji Prezesa UOKiK wydanych w 2022 roku
Authors:   Uniwersytet Wrocławski, Rutkowska-Tomaszewska Edyta , Zwaliński Artur ,   Uniwersytet Wrocławski
Published: July 2023

W niniejszym artykule dokonano przeglądu decyzji Prezesa Urzędu Ochrony Konkurencji i Konsumentów (dalej: Prezes UOKiK, Prezes Urzędu) wydanych w okresie od 1 stycznia do 31 grudnia 2022 roku. Przeanalizowano i oceniono wszystkie decyzje wydane przez Prezesa UOKiK we wskazanym wyżej okresie. Dokonano ich podziału na dwie zasadnicze kategorie wynikające z właściwości Prezesa UOKiK do wydawania decyzji w sprawach antykonsumenckich praktyk rynkowych na: decyzje w sprawach naruszenia zbiorowych interesów konsumentów oraz na decyzje w sprawie stosowania niedozwolonych postanowień umownych we wzorcach umów, a następnie w ich ramach na grupy według wiodących problemów szczegółowych. W zakresie stosowania klauzul niedozwolonych były to przede wszystkim decyzje dotyczące opłat alokacyjnych stosowanych w umowach ubezpieczeń na życie z funduszem inwestycyjnym UFK, ale także śmierci współposiadacza rachunku we wzorcach umów rachunku bankowego oraz wykonywania zleceń w obrocie na rynku instrumentami OTC. W przypadku naruszeń zbiorowych interesów konsumentów były to m.in. decyzje dotyczące zarówno umów kredytu konsumenckiego, jak i nieuczciwych praktyk rynkowych wprowadzających w błąd oraz informowania konsumentów o kursie walutowym przy rozliczaniu bezgotówkowej transakcji w walucie obcej.
Interaction sociale et cognition animale
Authors: Tison Rémi
Published: July 2023

Dans cet article, je traite de la nature des processus cognitifs sous-tendant nos attributions d’états mentaux aux animaux non humains. Selon la conception traditionnelle, nous n’avons qu’un accès indirect aux états mentaux d’autrui, qui doivent être inférés sur la base du comportement. Cette conception traditionnelle influence autant les débats conceptuels concernant l’esprit des animaux que les recherches empiriques sur la cognition animale. Or de récents travaux sur la cognition sociale humaine avancent plutôt une conception « interactionniste », selon laquelle les états mentaux peuvent parfois être directement perçus dans le comportement. J’applique dans cet article la conception interactionniste à l’attribution d’états mentaux aux animaux. Je conclus que celle-ci rend mieux compte des attitudes du sens commun à l’égard des états mentaux des animaux et est plus féconde pour la recherche empirique sur la cognition animale que la conception traditionnelle.
For Women Only? Reconsidering Gender Requirements for Uterine Transplantation Recipients
Authors: Wagner Darren N.
Published: July 2023

Uterine transplantation is an experimental procedure currently available only to cisgender women recipients suffering from absolute uterine factor infertility. Clinicians, researchers, and advocates have advanced the possibility of providing these quality-of-life transplantations to transgender women. This article examines the ethical and practical implications of removing sex- and gender-based requirements entirely for uterine transplantation recipients. Given the significant costs and risks, and the modest quality-of-life benefits, ethical arguments against offering uterine transplantations to people who do not identify as women but are otherwise suitable recipients are dubious and prejudicial. Successful uterine transplantations with non-women recipients could potentially diminish the socio-cultural connection between uterine functionality and womanhood, which is a key motivation for women now seeking this high-risk procedure.
A Scoping Review of Ethical and Legal Issues in Behavioural Variant Frontotemporal Dementia
Authors: Nair Anirudh , Berryessa Colleen M. , Dubljević Veljko
Published: July 2023

Behavioural variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia characterized by changes in personality, social behaviour, and cognition. Although neural abnormalities cause bvFTD patients to struggle with inhibiting problematic behaviour, they are generally considered fully autonomous individuals. Subsequently, bvFTD patients demonstrate understanding of right and wrong but are unable to act in accordance with moral norms. To investigate the ethical, legal, and social issues associated with bvFTD, we conducted a scoping review of academic literature with inclusion & exclusion criteria and codes derived from our prior work. Among our final sample of fifty-six articles, four mentioned bvFTD patient-offenders as unfit to stand trial by insanity, and sixteen mentioned the use of dementia evidence in a court of law to better understand the autonomy of bvFTD patients. Additional emergent issues that were discovered include: training police officers to handle situations involving bvFTD patients and educating healthcare providers on how to help caregivers navigate bvFTD. The current literature highlights the inadequacy of traditional applications of medico-legal categories such as autonomy, capacity and competence, in informing cognitive capacity assessments in clinical and legal settings and deserves consideration by neuroethicists.
Shooting competence of law enforcement officers as an indicator of their professionalism
Authors: Karimov Al'bert Amirovich
Published: July 2023

The novelty of the problem considered in the article lies in the introduction of the concept of "shooting competence". The research methodology is implemented with the help of a structural-content analysis of scientific papers devoted to the topic of this study and a synthesis of the practical experience of police officers and regulatory legal acts on the research topic. The scope of the study lies in the fact that the proposed set of pedagogical conditions will increase the level of development of shooting competencies and, in general, the preparedness of employees for the use of weapons. Conclusions. A model of shooting competence has been created, which considers all the constituent components that a police officer must possess, who, on duty, can use firearms. The subject of the study is the shooting competence of employees of the internal affairs bodies. The object of the study is the professional training of employees of internal affairs bodies. The purpose of the work is to study the main psychological and pedagogical aspects of the formation of shooting competence among students in educational organizations of the system of the Ministry of Internal Affairs of Russia in order to improve the learning process in professional training. The problem of insufficient knowledge of "shooting competence" is considered, which is interesting and relevant for the system of law enforcement structures in terms of the general professional training of employees of the internal affairs bodies. The problem of the formation of shooting competence meets the modern requirements for employees of internal organs more than ever.
About the work "Yakut folk music" by M.N.Zhirkov
Authors: Pavlova-Borisova Tat'yana Vladimirovna
Published: July 2023

The subject of the study is the research work of M.N. Zhirkov, which became the first monographic study of the musical culture of the Yakuts. The object of the study is the problems of musicology first posed by the author of this study. The article discusses such aspects as the difficult fate of the manuscript of M.N. Zhirkov's research, which was unpublished for a long time, and at the first publication was not published in its full form, in addition, the experience of a new reprint of this work in the 9th volume of M.N. Zhirkov's "Collected Works". Special attention is paid to those areas of his work that at that time were in the circle of the most pressing theoretical problems of musical culture of the peoples of the former Soviet Union.   The main conclusions of the study are the author's generalizations of the fundamental results of M.N. Zhirkov's work, which at the time of writing this work were advanced not only in terms of the level of development of Russian musicology, but now look quite modern in their relevance and fundamental nature. A special contribution of the author to the topic under development is the analysis of those parts of the study that were not published in the first publication of 1981. The novelty of the study lies in the fact that for the first time attention is drawn to the original full text of the original version of the "Yakut folk Music" by M.N.Zhirkov. The article summarizes the author's experience of the new edition of this unique work.
A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae
Authors: Walker Lucas M , Haycocks James RJ , Van Kessel Julia C , Dalia Triana N , Dalia Ankur B , Grainger David C
Published: July 2023

Many bacteria use quorum sensing to control changes in lifestyle. The process is regulated by microbially derived ‘autoinducer’ signalling molecules, that accumulate in the local environment. Individual cells sense autoinducer abundance, to infer population density, and alter their behaviour accordingly. In Vibrio cholerae, quorum-sensing signals are transduced by phosphorelay to the transcription factor LuxO. Unphosphorylated LuxO permits expression of HapR, which alters global gene expression patterns. In this work, we have mapped the genome-wide distribution of LuxO and HapR in V. cholerae. Whilst LuxO has a small regulon, HapR targets 32 loci. Many HapR targets coincide with sites for the cAMP receptor protein (CRP) that regulates the transcriptional response to carbon starvation. This overlap, also evident in other Vibrio species, results from similarities in the DNA sequence bound by each factor. At shared sites, HapR and CRP simultaneously contact the double helix and binding is stabilised by direct interaction of the two factors. Importantly, this involves a CRP surface that usually contacts RNA polymerase to stimulate transcription. As a result, HapR can block transcription activation by CRP. Thus, by interacting at shared sites, HapR and CRP integrate information from quorum sensing and cAMP signalling to control gene expression. This likely allows V. cholerae to regulate subsets of genes during the transition between aquatic environments and the human host.
Physico-chemical and Bacteriological Characterization of Hospital Effluents from Biamba Marie Mutombo Hospital Treated in the UASB Pilot Reactor
Authors: Mesongolo Credo L. , Musibono Dieudonné E. , Tangou Thierry T. , Mulaji Crispin K. , Lubieno Luis O. , Seke Max V. , Kusonika Athanase N. , Biey Emmanuel M.
Published: July 2023

The objective of this study was to characterize the wastewater from the BIAMBA Marie MUTOMBO hospital in terms of physico-chemical and bacteriological parameters, and to set up a pilot UASB reactor to treat this water. Two methods were used to conduct the investigations: observation and experimentation. Observations focused on wastewater management at the hospital and its surroundings, up to the point of discharge into the receiving environment. The analysis revealed that some parameters, such as COD, BOD5, turbidity, phosphorus, coliforms and fecal streptococci, exceeded discharge standards. A pilot UASB reactor was therefore proposed to treat the wastewater from the hospital (HBMM). The results were satisfactory, with values in compliance with standards for hospital effluent discharges. At the outlet of the pilot reactor, physico-chemical and bacteriological parameters such as COD showed a reduction in pollutant load of 93.7%, BOD5 of 93.3%, TSS of 75%, turbidity of 98.6% and phosphorus showed a value in compliance with discharge standards, with a reduction of 50%. Fecal coliforms at the outlet showed an efficiency of 100% and fecal streptococci of 99.9%, proving the effectiveness of the UASB pilot system for treating hospital effluents from the hospital (HBMM). This study has therefore shown that the implementation of a UASB pilot reactor can contribute to improving efficiency in the treatment of wastewater from Biamba Marie Mutombo Hospital.
Building Strong Foundations: Strategies for Enhancing Resilience in Children
Authors: Gupta S. M.
Published: July 2023

Resilience is the ability to adapt and thrive in the face of adversity. It is "The ability to bounce back or recover quickly from setbacks" [1]. In today's ever-changing world, it is important to foster resilience in children so they can overcome challenges and succeed in life. This paper highlights the importance of resilience among children. It encompasses the levels and stages of resilience. It also examines the factors affecting resilience among children and focuses on strategies for enhancing resilience in children. Finally, this article states the role of a researcher to enhance the resilience among children. This paper provides practical suggestions for parents, educators, and other caregivers. This work leads the children to develop the skills and mindset needed to navigate life's challenges with confidence and face adversity successfully.
Marketing Communication Strategy at Fashion Company "X" During a Pandemic Covid-19
Authors: Indrawan Jerry , Goenawan Felicia , Hadi Ido Prijana
Published: July 2023

This research was conducted to find out how the marketing communication strategy was carried out by fashion company "X" during the Covid-19 pandemic. In its marketing communication strategy, fashion company "X" has the goal of increasing sales of the products sold by fashion company "X". In achieving this goal, the fashion company "X" uses the AIDA model (Action, Interest, Desire, Action) to classify a person's phases in knowing a brand and taking action and using the elements in integrated marketing communication (IMC) to analyze strategy marketing communications used by fashion company "X". This type of research is descriptive qualitative. And using the case study method as well as in collecting data using interview techniques. In delivering its marketing communication strategy, fashion company "X" uses several online media according to their target market. In addition, they also use live shopping techniques. and the latter uses the data of every customer who purchases at their company to offer the latest products from fashion company "X". The results of this study are used to determine marketing communication strategies at the fashion company "X" during the Covid-19 pandemic and the latter uses the data of every customer who purchases at their company to offer the latest products from fashion company "X". The results of this study are used to determine marketing communication strategies at the fashion company "X" during the Covid-19 pandemic and the latter uses the data of every customer who purchases at their company to offer the latest products from fashion company "X". The results of this study are used to determine marketing communication strategies at the fashion company "X" during the Covid-19 pandemic
Conversations with Panamanian Parents Regarding Their Children with Disabilities
Authors: Lopez Naima Bhana , Rangel-Rodríguez Gabriela A. , Raulston Tracy J.
Published: July 2023

Over 8 million children under the age of 14 live with a disability in Latin American and Caribbean (LAC) countries. These children are often denied educational opportunities and related services that have the potential to enhance their quality of life. In this qualitative study, we conducted a secondary analysis of interviews with eight parents of individuals with disabilities living in the Republic of Panama. The aim of this study was to examine the parental perceptions of disability, communication supports afforded to individuals with disabilities, and enablers and barriers families face when raising, educating, and finding services for their children. Four general themes emerged from the analysis of the transcript: child characteristics, child communication, sources of support, and barriers to inclusion. Implications and possible solutions are discussed.
Leading Causes of Death Among Asian American Compared With Pacific Islander Individuals
Authors: Vo Jacqueline B. , Bess Jazmyn L. , Taparra Kekoa , Mitra Paloma R. , Berrington de González Amy , Freedman Neal D. , Shiels Meredith S. , Shing Jaimie Z.
Published: January 2025

This cross-sectional study compares the disaggregated mortality rates and leading causes of death among Asian American and Pacific Islander individuals.
Acute Ischemic Stroke Care Quality Improvement
Authors: Zhu Jinyi , Kim Kun-Woo Rafael , Yu Hanxuan , Gupta Ajay , Mushlin Alvin I. , Kamel Hooman , Pandya Ankur
Published: January 2025

This economic evaluation analyzes retrospective and prospective data in 9 quality measures to determine their value in improving care for patients who have had a stroke.
An Imperative for Public Sharing of Adverse Events of Gene Therapy Trials
Authors: Bonkowsky Joshua L. , Rajan Deepa S. , Eichler Florian
Published: January 2025

This Viewpoint describes the need for public sharing of adverse events associated with genetic therapies to improve patient safety.
Data-Driven Characterization of Individuals With Delayed Autism Diagnosis
Authors: Aizenberg Dan , Shalev Ido , Uzefovsky Florina , Eran Alal
Published: January 2025

This study used various machine learning approaches to identify and comparatively characterize groups of individuals with delayed autism diagnosis.
Pediatrician Perspectives on Incorporating Discussion of Police Encounters Into Anticipatory Guidance for Black Youth and Their Caregivers
Authors: Eugene Jeffrey M. , Nelson Maria , Neergaard Rebecca , Edmondson Emma , Capponi Sarah , Herrera M. Christina , Shea Judy A. , Yun Katherine , Jaffe Nicole , Premo Julie , Dalembert George
Published: January 2025

This study explores the barriers and facilitators to pediatricians discussing safely navigating police interactions with Black youth and their caregivers.
Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA
Authors: Najjar Rayan , Wang Xiaoxing , Pineda Jose Mario Bello , Alessi Hugh , Bays Alison , Bradley Robert K. , Jarvis James N. , Mustelin Tomas
Published: January 2025

Objective

To test whether messenger RNA (mRNA) splicing is altered in neutrophils from patients with systemic lupus erythematosus (SLE) and can produce neoantigens.

Methods

RNA sequencing of neutrophils from patients with SLE (n = 15) and healthy donors (n = 12) were analyzed for mRNA splicing using the RiboSplitter pipeline, an event‐focused tool based on SplAdder with subsequent translation and protein domain annotation. RNA sequencing from SARS‐CoV2–infected individuals was used as an additional comparator.

Results

Neutrophils from patients with SLE contained 521 statistically significant altered mRNA splicing events compared with healthy donor neutrophils, many of them affecting important immunologic pathways, myeloid function, transcription factors, and proteins involved in mRNA splicing. A subset of splicing events were only present in SLE samples, and some of them occurred at unannotated splice acceptor or donor sites. Two patients were particularly rich in such events. Only a small number of dysregulated splicing events were more pronounced in patients with active disease or with high type I interferons but were not detected in SARS‐CoV2–infected individuals, who also had high type I interferons. Besides causing a range of structural changes, 80 mRNA splice variants exclusive to SLE were predicted to translate into novel amino acid sequences. Peptides derived from these novel amino acid sequences were predicted to bind to the individual patients’ class I and II major histocompatibility complex molecules with high affinity.

Conclusion

We conclude that aberrant mRNA splicing in SLE has the potential to affect both the function of granulocytes and to generate novel autoantigens.
What Matters in Psoriatic Arthritis: A Comparison of Patient and Clinician Perspectives
Authors: Mease Philip J. , Husni M. Elaine , Siegel Evan , Furst Daniel E. , Mcilraith Melissa , Strand Vibeke , Hay M. Cameron
Published: January 2025

Objective

This study aimed to expand the understanding of the patient with psoriatic arthritis (PsA) experience and to compare/contrast patient and clinician prioritization of PsA dimensions.

Methods

We conducted four patients with PsA focus groups across three US rheumatology practices using mixed methods to identify attributes of PsA important to patients. Combination with extant attributes of PsA identified by a steering committee created a comprehensive list of attributes. In separate patient and physician Delphi exercises, participants distributed 100 points across items on the list according to importance as a dimension of PsA.

Results

Fifty‐one items describing PsA were generated. Thirty‐eight patients and 13 clinicians completed the last Delphi rating exercise. Patients distributed points across a wider range of items than physicians. Using group mean score per item, prioritization was compared between groups. Items with the top 10 mean scores for both groups included arthritis, disease activity, pain, fatigue, physical function, and spine symptoms. Other prioritized domains showed disparity: access to care, daily activities, stiffness, future health uncertainty, and sleep quality for patients versus specific disease skin and joint manifestations, comorbidities, structural damage, and disease management goals for clinicians.

Conclusion

Although concordance between patient and clinician perspectives regarding “what matters” in PsA was seen, significant areas of discordance were uncovered. Patients highlighted concerns about care access and uncertainty about the future and impact on aspects of life beyond physical symptoms, issues not usually discussed in a clinical visit. These differential prioritizations highlight opportunities for improvement in patient–clinician communications and delineate the need for more patient‐centered research.
Advancing Digital Transformation in Material Science: The Role of Workflows Within the MaterialDigital Initiative
Authors: Bekemeier Simon , Caldeira Rêgo Celso Ricardo , Mai Han Lin , Saikia Ujjal , Waseda Osamu , Apel Markus , Arendt Felix , Aschemann Alexander , Bayerlein Bernd , Courant Robert , Dziwis Gordian , Fuchs Florian , Giese Ulrich , Junghanns Kurt , Kamal Mohamed , Koschmieder Lukas , Leineweber Sebastian , Luger Marc , Lukas Marco , Maas Jürgen , Mertens Jana , Mieller Björn , Overmeyer Ludger , Pirch Norbert , Reimann Jan , Schröck Sebastian , Schulze Philipp , Schuster Jörg , Seidel Alexander , Shchyglo Oleg , Sierka Marek , Silze Frank , Stier Simon , Tegeler Marvin , Unger Jörg F. , Weber Matthias , Hickel Tilmann , Schaarschmidt Jörg
Published: January 2025

The MaterialDigital initiative represents a major driver toward the digitalization of material science. Next to providing a prototypical infrastructure required for building a shared data space and working on semantic interoperability of data, a core focus area of the Platform MaterialDigital (PMD) is the utilization of workflows to encapsulate data processing and simulation steps in accordance with findable, accessible, interoperable, and reusable principles. In collaboration with the funded projects of the initiative, the workflow working group strives to establish shared standards, enhancing the interoperability and reusability of scientific data processing steps. Central to this effort is the Workflow Store, a pivotal tool for disseminating workflows with the community, facilitating the exchange and replication of scientific methodologies. This article discusses the inherent challenges of adapting workflow concepts, providing the perspective on developing and using workflows in the respective domain of the various funded projects. Additionally, it introduces the Workflow Store's role within the initiative and outlines a future roadmap for the PMD workflow group, aiming to further refine and expand the role of scientific workflows as a means to advance digital transformation and foster collaborative research within material science.
Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control
Authors: Zolfagharian Ali , Demoly Frédéric , Lakhi Mohammad , Rolfe Bernard , Bodaghi Mahdi
Published: January 2025

Bistable mechanisms, characterized by their ability to maintain two distinct stable states under external stimuli, offer a versatile solution to engineering challenges, particularly in vibration suppression systems. While tuned mass dampers (TMDs) effectively mitigate vibrations at specific frequencies, their efficacy falls short across a broader spectrum. This work proposes enhanced adaptability for passive vibration reduction without dependence on complex control systems or external power sources by integrating bistable mechanisms into TMD systems. A bistable mechanism is designed based on numerical simulations and is 3D‐printed via fused filament fabrication. The bistable mechanism provides more adaptive characteristics by displacing the tuned mass on a flexible link. Following experimental testing, the optimized design for bistable mechanisms has been determined. Then, a chain of bistable mechanisms is introduced to achieve the desired displacement for carrying the TMD payload. The stroke length for the TMD vibration test has been customized to reduce system vibrations by carefully optimizing geometric configurations of bistable mechanisms.
Inverse‐Designed Dispersive Time‐Varying Nanostructures
Authors: Garg Puneet , Fischbach Jan David , Lamprianidis Aristeidis G. , Wang Xuchen , Mirmoosa Mohammad S. , Asadchy Viktar S. , Rockstuhl Carsten , Sturges Thomas J.
Published: January 2025

Time‐varying nanostructures allow to control the spatial and temporal properties of light. The temporal modulation of the nanostructures constitutes an additional degree of freedom to control their scattering properties on demand and in a reconfigurable manner. However, these additional parameters create a vast design space, raising challenges in identifying optimal designs. Therefore, tools from the field of photonic inverse design must be used to optimize the degrees of freedom of the system to facilitate predefined optical responses. To further develop this field, here a differentiable transition (T‐) matrix‐based inverse design framework is introduced for dispersive time‐varying nanostructures. The electron density of the material of the nanostructures is modulated non‐adiabatically as a generic periodic function of time. Using the inverse design framework, the temporal shape of the electron density can be manipulated to reach the target functionality. This computational framework is exploited, exemplarily, in two instances. First, the decay rate enhancement of oscillating dipoles near time‐varying spheres is controlled on demand. Second, using spatiotemporal metasurfaces, a system supporting asymmetric transmission of light at visible frequencies is designed. This work paves the way toward programmable spatiotemporal metasurfaces and space‐time crystals for a future generation of reconfigurable functional photonic devices.
Physics‐Based Design of Efficient Metasurface Temperature‐Adaptive Radiative Coatings
Authors: Hunt Gabriella M. , Oh Lance , Bruce Robert , Miragliotta Joseph A. , Ginn James , Warren Andrew P. , Spicer James B. , Shrekenhamer David B.
Published: January 2025

This work introduces a physics‐based model and detailed examination of how efficient VO2‐based, metasurface thermally‐adaptive radiative coatings (TARCs) can be designed through careful selection of the dielectric spacer material and thickness as well as tailoring of the tungsten‐doped vanadium dioxide (WxV1‐xO2 where x = 0 and 0.015) patch dimensions. This study explores how the phase and magnitude of transmission through the nanopatterned layer of the metasurface TARC are impacted by these parameters and subsequently influence the resulting contrast in emissivity between the low‐ and high‐temperature states. When these parameters are optimized, the emissive contrast (8–13 µm) is predicted to be as high as 0.725 and 0.607 respectively for the undoped and doped TARCs. Additionally, this study investigates the use of alumina (Al2O3), a dielectric spacer with significant mechanical stability, and experimentally demonstrate the realization of metasurface TARCs with notably high emissive contrast. The findings describe the fundamental limits of emissivity contrast that can be achieved with a metasurface TARC composed of a WxV1‐xO2 layer deposited atop an Al2O3 coated aluminum ground plane. Ultimately, the study provides a deeper understanding of the underlying physics of TARCs and demonstrates that metasurface engineering can be used to achieve enhanced control in tuning their emissive contrast.
Molecular Clip Strategy of Modified Sulfur Cathodes for High‐Performance Potassium Sulfur Batteries
Authors: Chen Tianyu , Min Zhiwen , Yu Zhenjiang , Zheng Mengting , Jiang Qingbin , Xu Huifang , Sun Yuanmiao , Hui Kwan San , Zha Chenyang , Lu Jun , Hui Kwun Nam
Published: January 2025

Potassium‐sulfur (K‐S) batteries are severely limited by the sluggish reaction kinetics of the cyclooctasulfur (cyclo‐S8) electrode with low conductivity, which urgently requires a novel cathode to facilitate activity to improve sulfur utilization. In this study, using the wet chemistry method, the molecular clip of Li+ is created to replace cyclo‐S8 molecular with the highly active chain‐like S62− molecular. The molecular clip strategy effectively lowers the reaction barrier in potassium‐sulfur systems, and the stretching of S─S bonds weakens the binding between sulfur atoms, facilitating the transformation of potassium polysulfides (KPSs). The as‐prepared cathode exhibits a reversible capacity of 894.8 mAh g−1 at a current rate of 0.5 C. It maintains a long cycle life of 1000 cycles with a stable coulombic efficiency in the potassium–sulfur cells without cathode catalysts. Operando XRD and Raman spectra combined with density functional theory (DFT) calculations, revealing the high efficiency of enhanced conversion of potassium polysulfide for high‐performance K‐S batteries.
A One Stone Three Birds Paradigm of Photon‐Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy
Authors: Zeng Shuang , Chen Chen , Yu Dan , Jiang Maojun , Li Xin , Liu Xiaosheng , Guo Zhihan , Hao Yifu , Zhou Danhong , Kim Heejeong , Kang Heemin , Wang Jingyun , Chen Qixian , Li Haidong , Peng Xiaojun , Yoon Juyoung
Published: January 2025

Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER‐centric imaging and therapeutics. Herein, using the targeted group‐assisted strategy (TAGS), an intriguing cyclooxygenase‐2‐targeted photodynamic conjugate, Indo‐Cy, strategically created, which exploits the enzyme's overabundance in the tumoral ER, especially under proinflammatory hypoxic conditions. This conjugate, with its highly precise ER imaging, embodies a trifunctional strategy: i) innovating an electron transfer mechanism, converting the hemicyanine moiety into an oxygen‐independent type I photosensitizer, thereby navigating around the hypoxia constraints of traditional PDT; ii) executing precise ER‐targeted PDT, amplifying caspase‐1/GSDMD‐mediated pyroptosis for ICD; 3) attenuating immunosuppressive pathways by inhibiting cyclooxygenase‐2 downstream factors, including HIF‐1α, PGE2, and VEGF. Indo‐Cy's multimodal approach potently induces in vivo tumor pyroptosis and bolsters antitumor immunity, underscoring cyclooxygenase‐2‐targeted dyes' potential as a versatile oncotherapeutics.
Mitochondrial Electron Flow Dynamics Imaging for Assessing Mitochondrial Quality and Drug Screening
Authors: Ren Youxiao , Wu Ling‐Ling , Song Wenjing , Gao Yanan , Shao Litao , Lu Zhiyuan , Wang Songsong , Shao Xintian , Yu Zhenjie , Zhang Mengrui , Wu Jing , Han Liwen , Zeng Kewu , Chen Qixin
Published: January 2025

Mitochondrial quality control is paramount for cellular development, with mitochondrial electron flow (Mito‐EF) playing a central role in maintaining mitochondrial homeostasis. However, unlike visible protein entities, which can be monitored through chemical biotechnology, regulating mitochondrial quality control by invisible entities such as Mito‐EF has remained elusive. Here, a Mito‐EF tracker (Mito‐EFT) with a four‐pronged probe design is presented to elucidate the dynamic mechanisms of Mito‐EF's involvement in mitochondrial quality control. Heightened aggregation of Mito‐EF in fiber‐like healthy mitochondria compared to round‐like damaged mitochondria is demonstrated, revealed Mito‐EF aggregation correlated with mitochondrial morphological remodeling, particularly in regions undergoing mitochondrial fission and fusion, and show the Mito‐EF signal associated with mitochondrial cristae maintained by Dynamin‐Related Protein 1 (DRP1). This underscores the importance of considering Mito‐EF in assessing mitochondrial quality control parameters. A novel drug screening evaluation parameter, Mito‐EF is also introduced to screen and discover mitochondrial‐targeted therapeutic modulators. This tracker provides new avenues for investigating the role of Mito‐EF in maintaining mitochondrial homeostasis and quality control, offering a potent tool for assessing mitochondrial quality and drug screening.
Traditional Chinese Medicine Borneol‐Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis‐Adaptive Treatment of Ischemic Stroke
Authors: Wang Yanan , Ma Xutao , Wang Xinyuan , Liu Liru , Zhang Xue , Wang Qiuyue , Zhu Yingfei , Xu Huanhua , Yu Liangmin , He Zhiyu
Published: January 2025

The scarcity of effective neuroprotective agents and the presence of blood‐brain barrier (BBB)‐mediated extremely inefficient intracerebral drug delivery are predominant obstacles to the treatment of cerebral ischemic stroke (CIS). Herein, ROS‐responsive borneol‐based amphiphilic polymeric NPs are constructed by using traditional Chinese medicine borneol as functional blocks that served as surface brain‐targeting ligand, inner hydrophobic core for efficient drug loading of membrane‐permeable calcium chelator BAPTA‐AM, and neuroprotective structural component. In MCAO mice, the nanoformulation (polymer: 3.2 mg·kg−1, BAPTA‐AM: 400 µg·kg−1) reversibly opened the BBB and achieved high brain biodistribution up to 12.7%ID/g of the total administered dose after 3 h post single injection, effectively restoring intracellular Ca2+ and redox homeostasis, improving cerebral histopathology, and inhibiting mitochondrial PI3K/Akt/Bcl‐2/Bax/Cyto‐C/Caspase‐3,9 apoptosis pathway for rescuing dying neurons (reduced apoptosis cell from 59.5% to 7.9%). It also remodeled the inflammatory microenvironment in cerebral ischemic penumbra by inhibiting astrocyte over‐activation, reprogramming microglia polarization toward an anti‐inflammatory phenotype, and blocking NF‐κB/TNF‐α/IL‐6 signaling pathways. These interventions eventually reduced the cerebral infarction area by 96.3%, significantly improved neurological function, and restored blood flow reperfusion from 66.2% to ≈100%, all while facilitating BBB repair and avoiding brain edema. This provides a potentially effective multiple‐stage sequential treatment strategy for clinical CIS.
Stability of Proton Superoxide and its Superionic Transition Under High Pressure
Authors: Wang Zifan , Yang Wenge , Kim Duck Young
Published: January 2025

Under extreme conditions, condensed matters are subject to undergo a phase transition and there have been many attempts to find another form of hydroxide stabilized over H2O. Here, using Density Functional Theory (DFT)‐based crystal structure prediction including zero‐point energy, it is that proton superoxide (HO2), the lightest superoxide, can be stabilized energetically at high pressure and temperature conditions. HO2 is metallic at high pressure, which originates from the 𝜋* orbitals overlap between adjacent superoxide anions (O2−). By lowering pressure, it undergoes a metal‐to‐insulator transition similar to LiO2. Ab initio molecular dynamics (AIMD) calculations reveal that HO2 becomes superionic with high electrical conductivity. The possibility of creating hydrogen‐mixed superoxide at lower pressure using a (Lix,H1‐x)O2 hypothetical structure is also proposed. This discovery bridges gaps in superoxide and superionicity, guiding the design of various H‐O compounds under high pressure.
Stabilizing Lattice Oxygen of Bi2O3 by Interstitial Insertion of Indium for Efficient Formic Acid Electrosynthesis
Authors: Wang Junjie , Tang Wu , Zhu Zhaozhao , Lin Yingxi , Zhao Lei , Chen Haiyuan , Qi Xueqiang , Niu Xiaobin , Chen Jun Song , Wu Rui
Published: January 2025

Bismuth oxide (Bi2O3) emerges as a potent catalyst for converting CO2 to formic acid (HCOOH), leveraging its abundant lattice oxygen and the high activity of its Bi−O bonds. Yet, its durability is usually impeded by the loss of lattice oxygen causing structure alteration and destabilized active bonds. Herein, we report an innovative approach via the interstitial incorporation of indium (In) into the Bi2O3, significantly enhancing bond stability and preserving lattice oxygen. The optimized In‐Bi2O3‐100 catalyst achieves over 90 % Faradaic efficiency for HCOOH production across a wide potential range, in both H‐cells and flow cells, maintaining robust stability after 100 hours of continuous operation. In situ surface‐enhanced infrared absorption spectroscopy and theoretical calculations reveal that the interstitial In doping precisely tunes the adsorption of CO2* and OCHO* intermediate, facilitating rapid conversion. Further in situ Raman spectroscopy confirms the role of In bolstering the oxidized structure's stability within Bi2O3, critical for sustaining lattice oxygen during electrochemical CO2 reduction.
Boosting One‐ and Two‐Photon Excited Fluorescence of Interpenetrated Tetraphenylethene‐Based Metal–Organic Frameworks (TPE‐MOFs) by Linker Installation
Authors: He Huihui , Li Ji , Zhuang Jiayi , Huang Jinyi , Meng Yuxuan , Lin Xi , Wei Zhangwen , Zhang Liangliang , Fang Yu , Pan Mei
Published: January 2025

Immobilizing organic chromophores within the rigid framework of metal‐organic frameworks (MOFs) augments fluorescence by effectively curtailing molecular motions. Yet, the substantial interspaces and free volumes inherent to MOFs can undermine photoluminescence efficiency, as they partially constrain intramolecular dynamics. In this study, we achieved optimization of both one‐ and two‐photon excited fluorescence by incorporating linkers into an interpenetrated tetraphenylethene‐based MOF (TPE‐MOF). This linker installation strategy enables fine‐tuning of both crystal packing density and ligand conformations. Strikingly, the desolvated MOFs exhibit remarkable two‐photon absorption (TPA) cross‐sections, reaching an impressive 8801 GM. Consequently, these materials demonstrate exceptional performance in one‐ and two‐photon excited cellular imaging of HepG2 cells. Our work introduces an innovative approach to enhancing two‐photon excited fluorescence (TPEF) and broadens the scope of research into one‐ and two‐photon excited fluorescence (1/2 PEF).
Sequential Infiltration Synthesis of Cadmium Sulfide Discrete Atom Clusters
Authors: Jayaweera Nuwanthaka P. , Havenridge Shana , Bielinski Ashley R. , Kim Kihoon , Thompson Niklas B. , Hoffman Justin M. , Wheaton Amelia M. , Sarkar Prasenjit , Pathak Rajesh , Elam Jeffrey W. , Liu Cong , Mulfort Karen L. , Martinson Alex B. F.
Published: January 2025

Exposure of soft material templates to alternating volatile chemical precursors can produce inorganic deposition within the permeable template (e.g. a polymer thin film) in a process akin to atomic layer deposition (ALD). While such sequential infiltration synthesis (SIS) processes have now been demonstrated for many metal oxides, we report an SIS process for a transition metal sulfide – CdS. Gas phase dimethyl cadmium and hydrogen sulfide precursors infiltrated into poly(4‐vinylpyridine) thin films result in the 3D‐nucleation of clusters consistent with a cubane‐type Cd4S4 core that are variably terminated with methyl, thiol and hydroxy capping ligands. First principles models and simulation of few‐atom Cd‐based clusters are consistent with electronic and vibrational spectroscopy and grazing‐incidence total X‐ray scattering measurements of 3D‐cluster‐arrays synthesized at 80 °C. The direct synthesis of few‐atom transition metal sulfide clusters within polymer thin films will provide a versatile new route to precision architectures for light‐absorbing materials including solar energy harvesting and conversion applications.