bluuebunny/crossref_metadata_2025 huggingface dataset:
Densidade de incidência de infecção primária de corrente sanguínea associada ao cateter venoso central no Brasil
Authors: Galvão Maria Renata da Silva , Rodrigues Mayara Cavalcante , Cunha Renata Kely Pimentel da , Silva Vera  Lúcia Morais da , Nascimento Camila Priscila Abdias do
Published: August 2021

Introdução: As Infecções Relacionadas à Assistência à Saúde são aquelas cuja aquisição está relacionada ao cuidado em saúde e que não estavam presentes no momento em que precede a assistência, oriundas da interação entre profissional e paciente. Dentre as principais infecções adquiridas relacionadas ao cuidado na assistência à saúde, destaca-se a Infecção de Corrente Sanguínea, associada ao cateter venoso central. Objetivo: Evidenciar a densidade de incidência de infecção primária de corrente sanguínea relacionada ao cateter venoso central e fatores associados no período de 2015 e 2019 nas Unidades de Terapia Intensiva (UTI) adulta, pediátrica e neonatal no Brasil. Metodologia: Trata-se de um estudo exploratório e descritivo com abordagem quantitativa, por meio de levantamento de dados em fontes secundárias, no período de análise, nas plataformas da ANVISA e DATASUS. Resultado e Discussão: Consoante os dados coletados, o Brasil realizou um número crescente de notificações de Infecções Primárias de Corrente Sanguínea com Confirmação Laboratorial por ano, assim como, houve aumento no número de serviços de saúde que realizaram a notificação desse tipo de evento. Constatou-se, ainda, o decréscimo na densidade de incidência dessas infecções em UTI adulto de 0,89 e pediátrica de 1,35. Entretanto, na UTI neonatal ocorreu o acréscimo de 0,1. Conclusão: Observou-se a redução na densidade da incidência de infecções e, também, incongruência na emissão desses dados, tanto na frequência quanto na quantidade de eventos. Essas notificações significam muito quando considerado a segurança do paciente, pois possibilitam estabelecer estratégias e metas que visam reduzir esses incidentes.
Estado nutricional e condições de saúde da equipe de enfermagem
Authors: Silva Valdinete Mendes da , Alves Julia de Souza , Silvestre Grasiela Cristina da Silva Botelho , Rocha Roseany Patrícia Silva , Gaiva Fayanne Araujo
Published: August 2021

Objetivo: Descrever o perfil sóciodemográfico, as medidas antropométricas e as condições de saúde dos profissionais de enfermagem que atuam nas Estratégias Saúde da Família. Metodologia: Trata-se de um estudo transversal, descritivo e de abordagem quantitativa, realizado com profissionais da enfermagem das Estratégias de Saúde da Família de um município do médio norte de Mato Grosso. Resultado: O estudo foi estruturado por meio da análise dos 32 questionários respondidos pelos profissionais de enfermagem das ESF’s. A coleta de dados se deu por intermédio de questionários Resultados: O estudo foi estruturado por meio da análise dos 32 questionários respondidos pelos profissionais de enfermagem das ESF’s. Observou-se que a maioria eram do sexo feminino de cor/raça parda. Quanto a idade destacam-se as faixas etárias de 27 a 48 anos. O tempo de atuação prevaleceu de 3 a 13 anos, quanto a renda familiar verificou o maior percentual de 3 a 4 salários mínimos. Quanto aos dados da medidas antropométricas e condições de saúde dos profissionais de enfermagem apresentou que 15 dos entrevistados estão com sobrepeso/pré-obesos. Com relação a Circunferência da Cintura predominou o risco muito elevado para obesidade. Conclusão: Os dados encontrados demonstram que o maior índice dos profissionais de enfermagem estão com sobrepeso/pré-obesos. Ao mensurar o estado nutricional dos profissionais, evidencia-se a relevância e importância de se avaliar tal variável visando a promoção e prevenção de futuros agravos a saúde e complicações ao indivíduo.
Use of alternative therapy with Psilocybin in oncologic patients with depression and/or anxiety disorders - integrative review
Authors: Silveira Frederico Marques , Mendes Amanda Pereira , Santos Mayara Rodrigues dos , Cerchi Júlia Ramos , Umeda Iris Tiyono Tavares , Melo Breno Basílio de , Casaburi Luiza Elena , Oliveira Mateus Nóbrega , Abdalla Douglas Reis
Published: August 2021

Cancer is not limited to the physical dimension, but it also affects the entire biopsychosocial context in which the patient is inserted, making him more susceptible to psychiatric disorders such as depression and anxiety. These often require pharmacological intervention, and the use of psilocybin, a substance found in mushroom species, is one of the alternatives considered today. The present study aims to carry out an integrative review regarding the use of alternative therapies, in this case Psilocybin, in cancer patients suffering from anxiety and / or depression disorders. The type of study carried out was an integrative literature review, which was based on a bibliographic survey of texts published between 2010 and 2021 on the PubMed platform. This survey took place between December 2020 and February 2021, with a review of three articles in total. Studies show a potential new line of alternative treatment for anxiety and depression in cancer patients, the use of psilocybin. The treatment is done quickly, sustained and lasting, in conjunction with psychotherapy there is improvement in a single dose. All the studies analyzed so far have been shown to be effective for the treatment of anxiety and depression in cancer patients. With this, psilocybin can be an alternative therapy for those patients in psychological distress due to cancer, especially for those who did not obtain a satisfactory response with the use of conventional treatment, allowing that in the future the substance may become a definitive therapeutic modality for patients in psychological distress due to cancer.
Possível uso da Psilocibina no tratamento psiquiátrico, incluindo sequelas da COVID-19
Authors: Bonifácio Myla Chistie Araujo Custodio , Bento Pietra Bruna Batrbosa , Trevisan Kaynara , Pereira Renata Cristina , Magri Micheli Patricia de Fátima , Aversi-Ferreira Tales Alexandre
Published: August 2021

Este trabalho discute acerca da ação da psilocibina no organismo humano e seu potencial terapêutico enquanto tratamento principal ou adjuvante para certos distúrbios psiquiátricos, mais especificamente a depressão e a ansiedade, como aquelas encontradas em pacientes que estão em cuidados paliativos e enfrentando o processo de fim de vida, mas também em pacientes nos quais o tratamento convencional não demonstrou eficácia. Estudos recentes também indicam a possibilidade da utilização da psilocibina no tratamento de sequelas psiquiátricas a longo prazo decorrentes da COVID. A literatura disponível indica que a psilocibina promove aumento da qualidade de vida, alterações na percepção do self, percepção de integralidade com o meio e experiências espirituais, o que se mostra especialmente importante nos grupos de pacientes supracitados. Além disso, demonstra pouco ou nenhum efeito colateral. Este trabalho realiza uma revisão para ratificar a hipótese do uso terapêutico da psilocibina na depressão e na ansiedade em populações que mais podem se beneficiar da terapia psicodélica.
Going Beyond the Add-and-Stir Critique: Tracing the Hybrid Masculinist Legacies of the Performative State
Authors: AGARWAL Amya
Published: August 2021

A West-centric knowledge bias has plagued International Relations (IR) for some time, prompting many non-West scholars to develop indigenous knowledge systems. In doing so, there is, however, a risk of both essentialization of certain cultures/histories; and reproducing the hierarchic and exclusionary structure of knowledge production. Moving beyond the add and stir critique style of non-Western approaches to IR, this paper explores the significance of connections and hybrid histories to understand gendered state practices. Through a case study of state performance in Kashmir, the paper traces the hybrid masculinist legacies (colonial, Brahminical and Kshatriya) derived from both Western and non-Western histories.
Challenging International Relations’ Conceptual Constraints: The International and Everyday Life across Borders in Southern Africa
Authors: SMITH Karen
Published: August 2021

One of the critiques of International Relations (IR) is that the discipline’s discursive boundaries are particularly rigid and continue to be shaped and maintained by dominant Western-centric concepts and discourses. This paper explores the apparent dichotomy between how concepts like ‘the international’ are interpreted by IR scholars and the experiences of ordinary people on which these concepts are imposed. How people engage with borders will be used as an illustration, with borders being regarded by IR scholars as constituting important boundaries that are essential to the field’s understanding of the world as consisting of neatly separated sovereign, territorial states. Two examples that highlight the arbitrary nature of national borders in Africa draw these assumptions into question and suggest that defining what does or does not constitute the international is, in reality, much more complex than suggested by the theoretical abstractions found in standard IR texts.
Spatiotemporal patterns in early life stage winter flounder Pseudopleuronectes americanus highlight phenology changes and habitat dependencies
Authors: McManus MC , Langan JA , Bell RJ , Collie JS , Klein-MacPhee G , Scherer MD , Balouskus RG
Published: August 2021

Decadal changes in the life history events of marine species are becoming increasingly important to identify under a warming climate, yet many long-term monitoring programs do not collect data at the spatiotemporal resolution needed to describe them. Such data are vital for understanding the southern New England/Mid-Atlantic winter flounderPseudopleuronectes americanusstock, a species hypothesized to be adversely impacted by warming waters via increased temporal overlap between its early life stages and predators. To provide insight into winter flounder early life history dynamics and context for resiliency of the stock, we examined ichthyoplankton data collected from 2 monitoring programs within Narragansett Bay, Rhode Island, USA: one spatially comprehensive dataset across the bay proper (2001-2008, 2016-2017), and the other a longer time series centered in one of the sub-estuaries of the bay (Mount Hope Bay, 1972-2017). By leveraging these datasets together, we conducted a spatiotemporal synthesis of early life stage winter flounder by evaluating changes in larval phenology, decadal coherence in larval spatial patterns, and correspondence between larvae and their subsequent life stage. We identified changes in larval phenology via earlier seasonal peaks in density through time. Results also indicated stable larval spatial patterns during a period of larval decline, as well as spatial coherence between larval and young-of-the-year stages. Using winter flounder as a model species, our results highlight the importance of high-resolution spatiotemporal ichthyoplankton sampling to identify changes in phenology and site fidelity for marine fishes.
Upaya Penanggulangan Covid-19 Dalam Keluarga Civitas Akademika Universitas Nurul Jadid
Authors: Hafifah Vivin Nur , Badriah Septi Nur , Malasari Putri Nur
Published: August 2021

Abstract. Covid-19 is a disease that attacks the respiratory system, symptoms include runny nose, sore throat, cough and fever. And in some people the symptoms can be more severe and cause pneumonia or difficulty breathing, a small number of these cases lead to death. This study aims to measure the efforts to deal with Covid-19 in the academic family of Nurul Jadid Probolinggo University. This type of research is qualitative with a descriptive approach. data collection on February 2, 2021 after obtaining approval from the Institute for Publishing, Research and Community Service (LP3M). Participants involved in the research were 8 people including 3 health faculty lecturers, 2 engineering faculty lecturers, 2 Islamic religion faculty lecturers and 2 education staff. The selection of participants from the population used a purposive sampling approach with the criteria being on campus when the research was carried out. The consent of the participants to be involved in the study was proven by signing the informed consent. Data collection was carried out through structured interviews using instruments in the form of new interviews containing questions about efforts to tackle Covid-19. The interview process was carried out by applying health protocols such as wearing masks, physical distancing, and washing hands before and after the interview. The data obtained were analyzed using the triangulation method of data sources to identify the categories, sub-themes, and themes of the participants' experiences. categories that have meanings are arranged to form sub-themes, then sub-themes that contain similar meanings as research themes. Data analysis was performed manually using thematic analysis methods. The results of his research show that the family of the Nurul Jadid University academic community has made efforts to tackle Covid-19. The conclusion is that the family of the academic community has made efforts to tackle Covid-19, in the form of wearing a mask while working, maintaining distance, washing hands (using a hand sanitizer), increasing immunity, applying the correct cough ethics, changing clothes or showering when you get home, controlling comorbidities and cleaning routinely objects that are often handled with disinfectants because they are aware that the Covid-19 disease is very dangerous and can die in a community.
Efektivitas Poster Pemberian Nutrisi Anak Terhadap Pengetahuan Orangtua Tentang Pemberian Nutrisi Dalam Pencegahan Stunting Di TK Bina Anaprasa Nurul Jadid
Authors: Munir Zainal , Rohman Abd , Putri Fina Zaiana , Wulandari Inayah Riski
Published: August 2021

The increasing number of stunting in Indonesia has crossed the WHO limit and has become a national issue that the incidence of stunting leads to unmet nutritional needs starting from the fetus to the age of toddlers, toddlers to toddlers. The purpose of the study was to find out the effectiveness of posters for giving children nutrition to parents' knowledge about nutrition in preventing stunting. This research is an intervention research by providing nutrition and stunting health education with 1 group pre-post test with pictorial media in the form of posters. The technique used is total sampling, namely all parents who have children from Bina Anaprasa Kindergarten. Data was collected by using a paired T-test approach through a pre-post test. The average result obtained is an average difference with a p value of 0.031, which means that there is an increase in knowledge of parents after being given nutrition education interventions in preventing stunting.
Efektivitas Dan Keamanan Vaksin Covid-19 : Studi Refrensi
Authors: Nugroho Setiyo Adi , Hidayat Indra Nur
Published: August 2021

Various strategies and development of the Covid-19 vaccine have been carried out for the control of the Covid-19 pandemic. Various vaccines have undergone clinical trials with promising results in various countries. The effectiveness and safety and short- and long-term side effects of vaccines are a major concern in clinical trials in these strategies and developments. Purpose: The purpose of this study is to find out the effectiveness and safety of the Covid-19 vaccine so that it can inform and increase public confidence in the Covid-19 vaccine through a reference study approach. Method: The research method we use here is a reference study using electronic databases through journals from international and national. Google Scholar, science direx, elsiver, Pubmed are used as the main Journal database for this reference study. Results: From the results of reference studies found that all vaccines in clinical trials have promising effectiveness and safety. The Pfizer-BiONTech vaccine is a vaccine that has a good level of effectiveness and safety with a value of 94.6% and does not cause serious side effects. Double-dose vaccination further improves the immune response in younger and older adults. Conclusion: The Covid-19 vaccine in clinical trials all demonstrates promising immunogenicity with varying levels of protective effectiveness and an acceptable safety profile.
HUBUNGAN TINGKAT PENGETAHUAN DAN SELF EFFICACY VAKSINASI COVID-19 PADA MAHASISWA FAKULTAS KESEHATAN UNIVERSITAS NURUL JADID
Authors: Nugroho Setiyo Adi , Istiqomah Binti , Rohanisa Fita
Published: August 2021

COVID-19 vaccine is the last weapon to reduce morbidity and prevent of death. However, in Indonesia there are many obstacles, the level of knowledge and self-efficacy is very important to note. The purpose of this study was to identify the relationship between the level of knowledge and self-efficacy in Covid-19 vaccination. A correlational study with a cross sectional approach was conducted on the student population of the Faculty of Health, Nurul Jadid University, there were 110 students who participated in this study. The independent variable is Knowledge Level while the dependent variable is Self Efficacy. The instrument in this study used a questionnaire. The results of data analysis with Spearman's rho, obtained a value of r = 0.756 and a value of p = 0.000. Based on the results of the statistical test, it was found that there was a very strong and positive patterned relationship between the level of knowledge and self-efficacy. The conclusion of this study is that there is a significant relationship between the level of knowledge and self-efficacy.
Hydrogen-Bonded Conjugated Materials and Their Application in Organic Field-Effect Transistors
Authors: Shi Xin , Bao Weiwei
Published: August 2021

Recent research on organic semiconductors has revealed that the composition of the constituent organic material, as well as the subtle changes in its structure (the stacking order of molecules), can noticeably affect its bulk properties. One of the reasons for this is that the charge transport in conjugated materials is strongly affected by their structure. Further, the charge mobility increases significantly when the conjugated materials exhibit self-assembly, resulting in the formation of ordered structures. However, well-organized nanostructures are difficult to obtain using classical solution processing methods, owing to their disordered state. A simple strategy for obtaining well-ordered material films involves synthesizing new conjugated materials that can self-organize. Introducing hydrogen bonding in the materials to yield hydrogen-bonded material superstructures can be a suitable method to fulfill these critical requirements. The formed hydrogen bonds will facilitate the assembly of the molecules into a highly ordered structure and bridge the distance between the adjacent molecules, thus enhancing the intermolecular charge transfer. In this minireview, hydrogen-bonded small molecules and polymers as well as the relationship between their chemical structures and performances in organic field-effect transistors are discussed.
Effects of Thresholding on Voxel-Wise Correspondence of Breath-Hold and Resting-State Maps of Cerebrovascular Reactivity
Authors: Fesharaki Nooshin J. , Mathew Amy B. , Mathis Jedidiah R. , Huddleston Wendy E. , Reuss James L. , Pillai Jay J. , DeYoe Edgar A.
Published: August 2021

Functional magnetic resonance imaging for presurgical brain mapping enables neurosurgeons to identify viable tissue near a site of operable pathology which might be at risk of surgery-induced damage. However, focal brain pathology (e.g., tumors) may selectively disrupt neurovascular coupling while leaving the underlying neurons functionally intact. Such neurovascular uncoupling can result in false negatives on brain activation maps thereby compromising their use for surgical planning. One way to detect potential neurovascular uncoupling is to map cerebrovascular reactivity using either an active breath-hold challenge or a passive resting-state scan. The equivalence of these two methods has yet to be fully established, especially at a voxel level of resolution. To quantitatively compare breath-hold and resting-state maps of cerebrovascular reactivity, we first identified threshold settings that optimized coverage of gray matter while minimizing false responses in white matter. When so optimized, the resting-state metric had moderately better gray matter coverage and specificity. We then assessed the spatial correspondence between the two metrics within cortical gray matter, again, across a wide range of thresholds. Optimal spatial correspondence was strongly dependent on threshold settings which if improperly set tended to produce statistically biased maps. When optimized, the two CVR maps did have moderately good correspondence with each other (mean accuracy of 73.6%). Our results show that while the breath-hold and resting-state maps may appear qualitatively similar they are not quantitatively identical at a voxel level of resolution.
A Competing Risk Nomogram for Predicting Cancer-Specific Death of Patients With Maxillary Sinus Carcinoma
Authors: Hu Mingbin , Li Xiancai , Gu Weiguo , Mei Jinhong , Liu Dewu , Chen Shaoqing
Published: August 2021

Objectives

Herein, we purposed to establish and verify a competing risk nomogram for estimating the risk of cancer-specific death (CSD) in Maxillary Sinus Carcinoma (MSC) patients.

Methods

The data of individuals with MSC used in this study was abstracted from the (SEER) Surveillance, Epidemiology, and End Results data resource as well as from the First Affiliated Hospital of Nanchang University (China). The risk predictors linked to CSD were identified using the CIF (cumulative incidence function) along with the Fine-Gray proportional hazards model on the basis of univariate analysis coupled with multivariate analysis implemented in the R-software. After that, a nomogram was created and verified to estimate the three- and five-year CSD probability.

Results

Overall, 478 individuals with MSC were enrolled from the SEER data resource, with a 3- and 5-year cumulative incidence of CSD after diagnosis of 42.1% and 44.3%, respectively. The Fine-Gray analysis illustrated that age, histological type, N stage, grade, surgery, and T stage were independent predictors linked to CSD in the SEER-training data set (n = 343). These variables were incorporated in the prediction nomogram. The nomogram was well calibrated and it demonstrated a remarkable estimation accuracy in the internal validation data set (n = 135) abstracted from the SEER data resource and the external validation data set (n = 200). The nomograms were well-calibrated and had a good discriminative ability with concordance indexes (c-indexes) of 0.810, 0.761, and 0.755 for the 3- and 5-year prognosis prediction of MSC-specific mortality in the training cohort, internal validation, and external validation cohort, respectively.

Conclusions

The competing risk nomogram constructed herein proved to be an optimal assistant tool for estimating CSD in individuals with MSC.
Interactive 3D Brain Helps You Learn How the Brain is Organized
Authors: Scotti Paul S. , Kulkarni Arman P. , Mazor Matan , Klapwijk Eduard , Huth Alexander
Published: August 2021

Which parts of your brain help you to talk to and understand others? How about recognizing your friends by their faces? Or remembering the last time you ate your favorite dessert? In this article we describe EduCortex, a free educational tool that allows you to play with a 3D brain, to discover how different parts of the brain work together to help you do things. By clicking on the brain, you will see words that are most associated with the selected brain region. For example, by entering a word like “language,” you can see the parts of the brain related to language. EduCortex works by using an online collection of information that automatically checks over 14,000 scientific papers, to see how the content of each paper relates to different brain parts.
Modeling Pollutant Emissions: Influence of Two Heat and Power Plants on Urban Air Quality
Authors: Cichowicz Robert , Dobrzański Maciej
Published: August 2021

Large industrial plants, power plants, and combined heat and power plants are popularly believed to be the main sources of point emissions, affecting both local and global air quality. This is because these installations emit significant amounts of pollutants at high altitudes every year. In this study, we investigate the impact of two solid fuel (hard coal)-fired CHP plants located within the urban agglomeration on the air quality of the city of Lodz in Poland (Europe). We used an OPA03 computer software to model the spatial distribution of pollutants. The results show that the annual average concentrations of pollutants were highest at an altitude of 25 m above ground level and decreased at lower measurement heights. The concentrations did not exceed permissible levels, reaching only 4% of national and international regulatory limits. We also made field measurements during the winter heating period, using an unmanned aerial vehicle (UAV) equipped with sensors to map the distributions of dust and gas pollutants in the areas with the highest concentrations of emissions from the two heat and power plants. Overall, the field measurements confirmed that it is not high-altitude emissions that have the greatest impact on local air quality.
Molecular Conditional Generation and Property Analysis of Non-Fullerene Acceptors with Deep Learning
Authors: Peng Shi-Ping , Yang Xin-Yu , Zhao Yi
Published: August 2021

The proposition of non-fullerene acceptors (NFAs) in organic solar cells has made great progress in the raise of power conversion efficiency, and it also broadens the ways for searching and designing new acceptor molecules. In this work, the design of novel NFAs with required properties is performed with the conditional generative model constructed from a convolutional neural network (CNN). The temporal CNN is firstly trained to be a good string-based molecular conditional generative model to directly generate the desired molecules. The reliability of generated molecular properties is then demonstrated by a graph-based prediction model and evaluated with quantum chemical calculations. Specifically, the global attention mechanism is incorporated in the prediction model to pool the extracted information of molecular structures and provide interpretability. By combining the generative and prediction models, thousands of NFAs with required frontier molecular orbital energies are generated. The generated new molecules essentially explore the chemical space and enrich the database of transformation rules for molecular design. The conditional generation model can also be trained to generate the molecules from molecular fragments, and the contribution of molecular fragments to the properties is subsequently predicted by the prediction model.
In Silico Reconstruction of Sperm Chemotaxis
Authors: Naruse Masahiro , Matsumoto Midori
Published: August 2021

In echinoderms, sperm swims in random circles and turns in response to a chemoattractant. The chemoattractant evokes transient Ca2+ influx in the sperm flagellum and induces turning behavior. Recently, the molecular mechanisms and biophysical properties of this sperm response have been clarified. Based on these experimental findings, in this study, we reconstructed a sperm model in silico to demonstrate an algorithm for sperm chemotaxis. We also focused on the importance of desensitizing the chemoattractant receptor in long-range chemotaxis because sperm approach distantly located eggs, and they must sense the chemoattractant concentration over a broad range. Using parameters of the sea urchin, simulations showed that a number of sperm could reach the egg from millimeter-order distances with desensitization, indicating that we could organize a functional sperm model, and that desensitization of the receptor is essential for sperm chemotaxis. Then, we compared the model with starfish sperm, which has a different desensitization scheme and analyzed the properties of the model against various disturbances. Our approach can be applied as a novel tool in chemotaxis research.
Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension
Authors: Bisserier Malik , Katz Michael G. , Bueno-Beti Carlos , Brojakowska Agnieszka , Zhang Shihong , Gubara Sarah , Kohlbrenner Erik , Fazal Shahood , Fargnoli Anthony , Dorfmuller Peter , Humbert Marc , Hata Akiko , Goukassian David A. , Sassi Yassine , Hadri Lahouaria
Published: August 2021

Pulmonary arterial hypertension (PAH) is a devastating lung disease characterized by the progressive obstruction of the distal pulmonary arteries (PA). Structural and functional alteration of pulmonary artery smooth muscle cells (PASMC) and endothelial cells (PAEC) contributes to PA wall remodeling and vascular resistance, which may lead to maladaptive right ventricular (RV) failure and, ultimately, death. Here, we found that decreased expression of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) in the lung samples of PAH patients was associated with the down-regulation of bone morphogenetic protein receptor type 2 (BMPR2) and the activation of signal transducer and activator of transcription 3 (STAT3). Our results showed that the antiproliferative properties of SERCA2a are mediated through the STAT3/BMPR2 pathway. At the molecular level, transcriptome analysis of PASMCs co-overexpressing SERCA2a and BMPR2 identified STAT3 amongst the most highly regulated transcription factors. Using a specific siRNA and a potent pharmacological STAT3 inhibitor (STAT3i, HJC0152), we found that SERCA2a potentiated BMPR2 expression by repressing STAT3 activity in PASMCs and PAECs. In vivo, we used a validated and efficient model of severe PAH induced by unilateral left pneumonectomy combined with monocrotaline (PNT/MCT) to further evaluate the therapeutic potential of single and combination therapies using adeno-associated virus (AAV) technology and a STAT3i. We found that intratracheal delivery of AAV1 encoding SERCA2 or BMPR2 alone or STAT3i was sufficient to reduce the mean PA pressure and vascular remodeling while improving RV systolic pressures, RV ejection fraction, and cardiac remodeling. Interestingly, we found that combined therapy of AAV1.hSERCA2a with AAV1.hBMPR2 or STAT3i enhanced the beneficial effects of SERCA2a. Finally, we used cardiac magnetic resonance imaging to measure RV function and found that therapies using AAV1.hSERCA2a alone or combined with STAT3i significantly inhibited RV structural and functional changes in PNT/MCT-induced PAH. In conclusion, our study demonstrated that combination therapies using SERCA2a gene transfer with a STAT3 inhibitor could represent a new promising therapeutic alternative to inhibit PAH and to restore BMPR2 expression by limiting STAT3 activity.
α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues
Authors: Dreneau Aurore , Krebs Fanny S. , Munier Mathilde , Ngov Chheng , Tritsch Denis , Lièvremont Didier , Rohmer Michel , Grosdemange-Billiard Catherine
Published: August 2021

Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli. Two of them are among the best 1-deoxy-d-xylulose 5-phosphate reductoisomerase inhibitors, with IC50 in the nM range, much better than fosmidomycin, the reference compound. They also showed an enhanced antimicrobial activity against E. coli on Petri dishes in comparison with the corresponding phosphates and the non-fluorinated phosphonate.
A Wearable Button Antenna Sensor for Dual-Mode Wireless Information and Power Transfer
Authors: Zhang Jiahao , Meng Jin , Li Wei , Yan Sen , Vandenbosch Guy A. E.
Published: August 2021

A novel wearable button antenna sensor is proposed for the concept of simultaneous wireless information and power transfer (SWIPT). This integrates two working modes for the transfer of power and information, respectively, and optimizes transfer efficiency. An omni-directional radiation pattern is achieved in the 3.5 GHz World Interoperability for Microwave Access (WiMAX) band to support on-body wireless communications, while a circularly polarized broadside radiation pattern is obtained in the 5 GHz wireless local area networks (WLAN) band to harvest power. The measured −10 dB return loss bandwidths are 4.0% (3.47–3.61 GHz) in the lower band, and 25.0% (4.51–5.80 GHz) in the higher band, respectively. An artificial magnetic conductor (AMC) structure with wideband characteristics is applied to obtain a low-profile design and to increase the stability of the antenna sensor. A high radiation efficiency of over 80% in the whole working band is observed. The specific absorption rate (SAR) of the proposed antenna sensor is below 0.509 W/kg at 3.55 GHz, and below 0.0532 W/kg at 5.5 GHz, respectively, which is much lower than the European standard threshold of 2 W/kg. All these characteristics make the designed antenna sensor suitable for on-body information transmission and off-body energy harvesting. The antenna sensor has been prototyped. Simulations and measurements agree well, proving the validity of the new concept.
Statistical analysis of predictors of the effectiveness of complex therapy in patients with skin scarring
Authors: Kazantseva. K. V. , Frolkov V. K. , Nagornev S. N. , Gusakova E. V. , Nagorneva M. S.
Published: August 2021

The variation of indicators that characterize skin scarring increases in patients with metabolic syndrome, which may affect the effectiveness of therapeutic measures. It has been found that pathological processes in the skin scar in the initial state correlate to the greatest extent with the index of insulin resistance, the atherogenic coefficient and the coefficient of antioxidant protection. It is proved that the effectiveness of complex physiotherapy with the addition of the internal intake of medium-mineralized water «Essentuki №17» directly correlates with an increase in tissue sensitivity to insulin and the activation of antioxidant enzymes, as well as with a decrease in dyslipidemia. Linear regression equations are presented to determine significant predictors of treatment effectiveness, which can lead to the creation of individualized therapeutic programs using preformed and natural physical factors.
Influence of complex medical rehabilitation methods with the inclusion of nicotinic acid electrophoresis on the dynamics of metabolic status indicators in patients with myocardial infarction after percutaneous coronary interventions
Authors: Smirnova Irina Nikolaevna , Antipova Inna Ivanovna , Titskaya Elena Vasilievna , Tonkoshkurova Anna Vladimirovna , Maritskaya Ekaterina Aleksandrovna
Published: August 2021

A study of the metabolic status of 123myocardial infarction patients who underwent emergency percutaneous coronary intervention and were admitted to the inpatient stage of rehabilitation has been carried out. The examination of the patients revealed a high incidence of hyperglycemia, hyperuricemia, dyslipidemia and atherogenic cholesterol fraction. It has been found that the administration of a pathogenetically based therapeutic complex including physical therapy, manual massage, dry carbon dioxide baths, and 1% nicotinic acid electrophoresis has a significant antiatherogenic effect, and contributes to the correction of uric acid and glucose levels, and insulin resistance.
Nitric oxide and interval hypoxic training in COVID-19 rehabilitation— new research direction
Authors: Tsyganova Tatyana Nikolaevna , Egorov Egor , Voronina Tamara Nikolaevna
Published: August 2021

COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, primarily affects lung tissue and disrupts gas exchange, leading to acute respiratory distress syndrome, systemic hypoxia, and lung damage. The search for methods of prevention and rehabilitation, especially after suffering from pneumonia caused by COVID-19, is on the agenda. This article discusses the possibilities of the interval hypoxic training (IHT) method for preventing infections by initiating nitric oxide production in the body. One of the main effects of IHT is the balanced stimulation of nitric oxide (NO) secretion. Over the past two decades, there has been an increasing interest in the function of nitric oxide (NO) in the human body. Nitric oxide plays a key role in maintaining normal vascular function and regulating inflammatory processes, including those leading to lung damage and the development of acute respiratory distress syndrome (ARDS). Our immune system destroys bacteria and viruses by oxidative burst, i.e. when oxygen accumulates inside the cell. This process also involves nitric oxide, a signaling molecule that has an antibacterial and antiviral effect, as well as regulates vascular tone and affects the permeability of the cell wall. Interval hypoxytherapy enhances endogenous oxidative protection and increases the amount of nitric oxide, thus allowing the body’s cells to resist infection more effectively. Mitochondrial NOS induction and mitochondrial NO synthesis increase under the action of pathogenic factors on the cell. By modulating the activity of mtNOS and the synthesis of mitochondrial NO, it is possible to increase the resistance to hypoxic effects. Interval hypo-hyperoxic training as an effective non-specific method of increasing the body’s defenses is indispensable not only in the prevention of viral infection, but also in rehabilitation after viral pneumonia, as well as as a method that reduces the severity of viral infection in the event of infection.
Dynamics of the clinical state of patients with peri-implantitis under conditions of complex application of physiotherapy technologies
Authors: Livshits V. I. , Nagornev S.N. , Frolkov V.K. , Gvetadze R.Sh.
Published: August 2021

The article presents the results of the treatment of inflammatory complications in patients with orthopedic constructions on dental implants using the course complex application of low-intensity infrared laser therapy and low-frequency electrostatic therapy. It has been shown that under the influence of a complex of physiotherapeutic factors, a more pronounced inverse dynamics of the clinical manifestations of peri-implantitis is observed in comparison with the standard treatment regimen, which has a positive effect on the indicators of the secondary stability of the implants themselves. The mechanisms of realization of the therapeutic efficiency of a low-intensity laser and a low-frequency electrostatic field are considered from the medical and biological point of view. The analysis of the study allows concluding that the course complex application of physiotherapeutic technologies in the treatment of post-prosthetic inflammatory complications during dental implantation is highly effective. The addition of the standard treatment regimen with the combined use of a low-frequency electrostatic field and laser therapy has a positive effect on the regression of the clinical manifestations of peri-implantitis and on the index indicators of the patients’ dental status. The increase in therapeutic efficiency observed when using a low-frequency electrostatic field in combination with an infrared laser of the complex is realized due to the potentiating type of interaction of physical factors, which is based on various points of application and the mechanisms of their corrective activity.
Assessment of the dynamics of indicators of morphological and functional characteristics of the skin in patients with the combined subtype of rosacea under the influence of complex phototherapy
Authors: Novikov K. A. , Tamrazova O. B. , Matushevskaya Yu. I.
Published: August 2021

Rosacea is a common chronic inflammatory dermatosis of vascular origin, characterized by a lesion of the face skin in the form of erythema and papulopustular elements. Taking into account the new research devoted to the treatment of rosacea, it is of scientific and practical interest to develop new methods for the treatment of this dermatosis using complex physiotherapy approaches and their synergy, for example, IPL radiation (without the use of photo filters) and submilisecond neodymium 1,064nm laser radiation. Material and methods. The study included 130patients with the combined subtype of rosacea (CSR) with varying degrees of severity of ETR and PPR. In order to study the effectiveness of complex photo- and laser therapy of CSR, all patients were divided into 4groups by simple randomization (envelope method). The treatment of the patients in each separate group included: group I — laser therapy and 1% metronidazole cream; group II — phototherapy and 1% metronidazole cream; group III — complex photo-laser therapy and 1% metronidazole cream; group IV — comparison group, patients received only 1% metronidazole cream. This work takes into account the synergism of both physiotherapeutic effects provided by non-truncated (without the use of photo filters) IPL radiation and submilisecond neodymium 1,064 nm laser radiation, as well as the increased destruction of pathologically altered vessels observed during the sequential use of both procedures, and the developed original method of treating patients with CSR. Conclusion. Based on the obtained results, it was concluded that the maximum improvement in the morphofunctional parameters of the skin was in the third group of patients with CSR. The increase in the hydration index of the skin exceeded the indicators of the other groups of patients with CSR. Also, the intensity of sebum production decreased most significantly. There was a maximum narrowing of the excretory ducts of the sebaceous glands, while in the other groups, the narrowing of the excretory ducts of the sebaceous glands occurred to a lesser and equal extent. Such changes reflect the pronounced effect of complex phototherapy on the tone of the sphincter of the excretory duct, the intensity of sebum production, as well as on the synthesis of collagen and elastin, which is reflected in the maximum approximation to the indicators of the group of healthy volunteers of such characteristics as «hydration» and «smoothness».
Experience in the use of physical factors during the recovery of the renal parenchyma after percutaneous nephroscopy
Authors: Gornostaev V. N. , Gurtskoy R. A. , Shulzhenko V. V.
Published: August 2021

The article reflects the results of the use of physical factors to restore the renal parenchyma in the early postoperative period after percutaneous nephroscopy in patients with urolithiasis. Material and methods: the study included 80patients with concretions of the renal pelvis after percutaneous nephroscopy (45men and 35women, average age — 46 years), who were divided into 2 comparable groups: groupI (main group) — 40 patients who underwent intravenous laser blood irradiation (ILBI) and ozone therapy — 6 procedures in the preoperative period, and polarized light and ILBI — 6 procedures in the early postoperative period; groupII (control group), which served as a background in the main group, were prescribed non-steroidal anti-inflammatory drugs after the surgery, taking into account bacterial urine culture. Inclusion criteria: patients with urolithiasis aged 28 to 62 years; indications for percutaneous nephroscopy. Exclusion criteria: concomitant diseases; compliance; pregnancy; acute inflammatory kidney diseases; abnormalities of the upper urinary tract. Results: The combined use of ILBI, ozone therapy and polarized light in the pre- and early postoperative period in patients with urolithiasis after percutaneous nephrolithotripsy allowed improving clinical, laboratory, subjective and objective indicators, as well as shortening the recovery period of the renal parenchyma, which was confirmed by the data of ultrasound studies in the dynamics in the form of a significant reduction in the recovery period of the index of renal vessels resistance and reduction of edema of the renal parenchyma. As a result of the application of the developed complex, the total bed-day of patients’ stay in the hospital decreased, and there was a rapid recovery of capacity to work. Conclusion: The developed method of the combined use of ILBI, ozone therapy and polarized light in the pre- and early postoperative period in patients with urolithiasis after percutaneous nephrolithiasis is pathogenetically justified and highly effective, which allows us to recommend it for wide use in urological practice.
Physical factors in the complex treatment of patients with rheumatoid arthritis
Authors: Lutoshkina Mariya Georgievna Lutoshkina Mariya Georgievna , Yarustovskaya Olga Viktorovna , Gerasimenko Marina Yurievna , Evstigneeva Inna Sergeevna , Rubchenkova Svetlana Aleksandrovna
Published: August 2021

There are no agents specifically stabilizing or reliably stopping the progression of rheumatoid arthritis. Rational and long-term use of drugs often allows achieving favorable clinical results, but they have a wide range of side effects and a number of serious complications. Therefore, the search for new effective means and, above all, complexes using physical treatment methods continues. Scientific studies of recent years have shown a number of fundamentally new possibilities for using physical factors. It is necessary to take into account the combined and complex, systemic and local use of physical factors in the treatment and rehabilitation of patients with rheumatoid arthritis, with the consideration of inflammatory activity, the course of the disease, the form and stage of the process, sulfur factor and the presence of synovitis, and drug treatment of basic and symptomatic therapy. It is important to pay attention to indications and contraindications for the use of physical factors. A special role in complex treatment belongs to physiotherapy exercises and massage. Thus, comprehensive rehabilitation programs have great potential for medications and physical treatment methods, which are regularly updated.
Analysis of age groups of museum contestants at the State Darwin Museum
Authors: Donskov D.G.
Published: August 2021

Since 1998, at the State Darwin Museum, all major exhibitions, as well as exhibitions detailing the main idea of the museum, are certainly accompanied by competitive programs for visitors. The purpose of this study was to identify the dynamics of age groups of competitors for the period 2009–2019. Based on the data obtained, it can be concluded that museums need to: maintain a stable interest among younger schoolchildren, build a communication policy with young people, focusing on current trends, create special programs for preschool children with parents, offer more interactive products for adults themselves, in line with increasing demand.
Quantistica — and style and gender in the superposition of quantic art
Authors: Ginzburg G.N.
Published: August 2021

The author of the paper is based on the provisions of the “Quantum Art” manifesto, created in 2008 by Roberto Denti, an Italian theorist, architect, artist, computer graphics and designer. In his opinion, the avant-garde styles of the twentieth century, which are based on a spontaneous image of a religious, meditative, psychedelic and narcotic trance seen in an altered state (such as visionary art, abstraction, surrealism, etc.), should be perceived as special cases of quantism, fixing random images of altered consciousness, but the authors are not aware of the causal relationship with the galactic information field, the quantum structure of the Universe, confirmed by the latest discoveries of the world scientific community in the field of cosmogony and quantum mechanics.
The duality of Vladimir Vysotsky's “creating soul”
Authors: Koptev L.N.
Published: August 2021

The “creating soul” of the poet and actor Vysotsky is divided into angelic and demonic. Early showing up demonic more and more captures the power over the poet's self and his work, taking different looks. The choice between creative and destructive forces determines not only the creative, but also the human destiny of Vysotsky.