bluuebunny/crossref_metadata_2025 huggingface dataset:
Coronavirus Disease 2019 (COVID-19): Patogenesis, Manifestasi Klinis dan Pilihan Terapi
Authors: Levani Yelvi , Prastya Aldo Dwi , Mawaddatunnadila Siska
Published: September 2023

Coronavirus Disease 2019 (COVID-19) ditemukan pada akhir tahun 2019 tepatnya bulan Desember di Kota Wuhan, Provinsi Huebei, China dan kemudian menyebar ke hampir seluruh dunia. Covid-19 disebabkan oleh betacoronavirus jenis baru yang cenderung mirip SARS-CoV dan MERS-CoV. Tujuan penulisan ini untuk memberikan telaah mengenai patofisiologi, manifestasi klinis, dan perkembangan penelitian tatalaksana Covid-19. Jenis review yang digunakan dalam artikel ini berbentuk literature review terhadap 41 artikel Covid-19 dengan menggunakan database PubMed dan Google Scholar. Covid-19 termasuk dalam genus betacoronavirus, hasil anasilis menunjukkan adanya kemiripan dengan SARS. Gejala umum di awal penyakit adalah demam, kelelahan atau myalgia, batuk kering. Serta beberapa organ yang terlibat seperti pernapasan, gastrointestinal, dan neurologis. Sampai saat ini, WHO dan beberapa Negara sedang melaksanakan uji klinis untuk menemukan obat yang tepat untuk Covid-19, studi ini bernama SOLIDARITY. Terdapat 4 kelompok dalam studi ini, yaitu kelompok LPV/r dan Interferon-beta, Remdesivir, Klorokuin dan Hidroksiklorokuin. Faktor virus dengan respon imun menentukan keparahan dari infeksi Covid-19. Gejala umum di awal penyakit adalah demam (83-98%), kelelahan atau myalgia, batuk kering (76-82%) dan sesak napas (31-55%). Dari telaah terhadap studi yang ada didapatkan bahwa sampai saat ini Remdesivir adalah obat yang paling berpotensi efektif terhadap Covid-19, walaupun begitu, masih dibutuhkan penelitian lebih lanjut dengan melakukan uji klinis yang lebih luas.
Aktivitas Antimikroba Perasan Daun Kirinyuh (Chromolaena odorata L.) terhadap Candida albicans dan Pseudomonas aeruginosa
Authors: Ernawati Ernawati , Jannah Nur
Published: September 2023

Daun kirinyuh (Chromolaena odorata) mengandung fenol, flavonoid, tannin, alkaloid dan saponin yang berpotensi sebagai senyawa antimikroba. Tujuan penelitian adalah untuk mengetahui aktivitas antimikroba daun kirinyuh terhadap Candida albicans dan Pseudomonas aeruginosa. Penelitian ini merupakan eksperimen laboratorium, pengujian antimikroba melalui metode difusi agar dengan kontrol positif (K+) menggunakan amoxilin untuk Pseudomonas aerugynosa dan ketokonazol untuk Candida albicans, aquades sebagai kontrol negatif (K-), dan perasan daun kirinyuh konsentrasi 100%, 80%, 60%, 40%, dan 20%. Bahan-bahan yang digunakan adalah isolat Candida albicans dan Pseudomonas aeruginosa, media MHA, aquades, amoxilin dan ketokonazol. Data diameter zona hambat yang dihasilkan setelah inkubasi 24 jam dianalisis secara deskriptif dengan mengklasifikasikan respon hambat sangat kuat (> 20-30 mm), kuat (10-20 mm), sedang (5-10 mm), lemah (< 5 mm). Hasil penelitian menunjukkan rata-rata zona hambat Candida albicans pada konsentrasi 20%, 40%, 60%, 80%, dan 100% adalah 10,3 mm, 11,03 mm, 11,66 mm, 12,83 mm, dan 13,82 mm, sedangkan untuk Pseudomonas aeruginosa 7,33 mm, 12,46 mm, 13,73 mm, 14,26 mm, dan 15,63 mm.  Hasil analisis data berdasarkan kategori respon hambat pertumbuhan termasuk kategori kuat dan sedang khusus pada konsentrasi 20% pada Pseudomonas aeruginosa.  Kesimpulan perasan daun kirinyuh memiliki aktivitas antimikroba terhadap pertumbuhan Candida albicans dan Pseudomonas aeruginosa..
Perbandingan Kadar HbA1c pada Pasien Diabetes Melitus Tipe 2 yang Disertai Hipertensi dan Tanpa Hipertensi di Rumah Sakit Umum Daerah Duri, Mandau, Bengkalis, Riau
Authors: Haryati Annisa Ichlasia , Tyas Tri Ariguntar Wikaning
Published: September 2023

Diabetes Melitus (DM) merupakan penyakit yang terjadi saat pankreas tidak dapat menghasilkan hormon insulin yang cukup atau ketika tubuh tidak dapat menggunakan insulin tersebut dengan efektif. Komplikasi DM terbanyak adalah hipertensi. Untuk menghindari komplikasi tersebut diperlukan kontrol glikemik berupa pemeriksaan kadar HbA1c. Pemeriksaan HbA1c adalah pemeriksaan yang berfungsi untuk mengukur rata-rata jumlah hemoglobin HbA1c yang berikatan dengan glukosa selama tiga bulan terakhir. Penelitian ini bertujuan untuk mengetahui perbandingan kadar HbA1c pada pasien DM tipe 2 yang disertai hipertensi dan tanpa hipertensi di Rumah Sakit Umum Daerah (RSUD) Duri, Mandau, Bengkalis, Riau. Penelitian ini menggunakan desain studi cross sectional dengan teknik pengambilan purposive sampling yang mengambil data dari rekam medis pasien DM sebanyak 124 sampel yang terdiri atas 62 sampel penderita DM dengan hipertensi dan 62 sampel penderita DM tanpa hipertensi. Hasil penelitian didapatkan nilai rerata kadar HbA1c pada penderita DM tipe 2 dengan hipertensi 10,742 (SD±2,413) dan pada penderita DM tipe 2 tanpa hipertensi 9,498 (SD±1,336). Secara statistik terdapat perbedaan bermakna antara rerata kadar HbA1c pada penderita DM tipe 2 yang disertai hipertensi dengan tanpa hipertensi. dengan nilai p < 0,005. Pemantauan kadar HBA1c dapat membantu mencegah komplikasi DM.
Implementasi Pemberdayaan Masyarakat Desa dalam Program MBKM sebagai Hilirisasi Riset Unggulan Perguruan Tinggi
Authors: Sari Fatma , Kurniaty Ika , Gustia Helfi , Hendrawati Tri Yuni , Anggaraini Nisrina Harum , Cakrawala Orion Nawandie
Published: September 2023

Program pengabdian kepada masyarakat dikembangkan pada program penelitian Kebijakan Merdeka Belajar Kampus Merdeka digagas untuk pemberdayaan masyarakat melibatkan masyarakat.  Desa Pantai Harapan Jaya Muara GembongBekasi membudidayakan rumput laut sebagai mata pencaharian.Rumput laut yang dibudidayakan termasuk kelas alga merah jenis Gracilaria sp. Gracilaria sp mempunyai kandungan agarosa dan agaropektin cukup baik, yang dapat menghasilkan agar-agar dengan kekuatan gel kuat dan kokoh. Tujuan hilirasasi hasil riset untuk pemberdayaan masyarakat dengan meningkatkan produk utama desa yaitu runput laut, meningkatkan produksi air bersih dengan adanya instalasi air bersih dan strategi pemasaran produk olahan rumput laut selain itu pemberdayaan hidroponik sebagai produk tambahan masyarakat desa. Metode pelaksanaan pelatihan dan pendampingan hal teknis, manajemen dan pemasaran. Luaran kegiatan yang dicapai yaitu produk olahan rumput laut, hasil hidroponik, dan juga pemberian alat instalasi air. Produk- produk tersebut kemudian di pasarkan melalui e commerce dan WEB agar tercipta kemandirian dan juga meningkatkan pendapatan masyarakat desa Pantai Harapan Jaya Muara Gembong
ЛЕКСИКА ПОХОВАЛЬНОГО Й РОДИЛЬНОГО ОБРЯДІВ У СЛОВНИКУ «ГУЦУЛЬСЬКА ДІАЛЕКТНА ЛЕКСИКА ТА ФРАЗЕМІКА В УКРАЇНСЬКІЙ ХУДОЖНІЙ МОВІ»
Authors: ҐРЕЩУК Василь , ҐРЕЩУК Валентина
Published: September 2023

У статті висвітлена лексика поховального та родильного обрядів, лексикографічно опрацьованих у словнику «Гуцульська діалектна лексика та фраземіка в українській художній мові». Предметом аналізу стала низка гуцульських діалектних слів у ділянці поховальних і родильних обрядодійств. Дослідження встановило, що лексикографічна інтерпретація лексики поховального й родильного обрядів дає змогу моделювати гуцульську мовну картину світу в окресленому сегменті, глибше з’ясувати особливості світобачення та світовідчуття горян.
Incontinentia Pigmenti in a 3-Year-Old Female: A Case Report
Authors: Mishra Anjali , Taylor Mitchell , Kauper Ryan , Kubesh Molly
Published: September 2023

Incontinentia Pigmenti (IP), also known as Bloch-Sulzberger syndrome, is a rare X-linked genetic disorder characterized by a distinctive cutaneous manifestation along with variable systemic involvement. We present a case of a 3-month-old female infant diagnosed with IP, highlighting the clinical features, diagnostic approach, and management strategies. Early recognition and multidisciplinary care are crucial for optimizing outcomes in affected infants.
Access to the Civil Service in the Democratic Republic of Congo
Authors: Kanowa Obed Kongolo
Published: September 2023

Access to the public service is a guaranteed right for all Congolese in the Democratic Republic of Congo. This right of access to the public service is framed by legal texts which determine the conditions of recruitment to the public service, the methods of recruitment … in Congolese law, there are several legal texts relating to the statutes of the public service. As a result, this study is particularly structured around law n°16/013 of July 15, 2016 on the status of career agents in the State's public services. Thus, within the framework of this study, removed the prolegomena, we deciphered the question of the access to the public service in Congolese Positive Law, by making a taxonomy of the related conditions and by elaborating on the recruitment as a modality of access to the civil service in accordance with the legal texts in this case.In order to carry out this study, we have recourse from time to time to ComparativeLaw. These are the main features of this study.
Mapeamento das áreas suscetíveis a inundações na bacia hidrográfica do rio Tejipió, em Pernambuco, Brasil
Authors: Pessoa Neto Amaury Gouveia , Silva Simone Rosa da , Barbosa Ioná Maria Beltrão Rameh
Published: September 2023

O processo de urbanização em países latino-americanos, como o Brasil, evoluiu com maior intensidade em meados do século XX, porém de forma acelerada e desordenada, modificando consideravelmente as condições de uso da terra e padrões de paisagem, resultando em significativas alterações no ciclo hidrológico. Uma das consequências dessas transformações foi o aumento da ocorrência de inundações, que se tornou um dos principais problemas enfrentados pela sociedade. Dessa maneira, o presente trabalho buscou mapear as áreas suscetíveis a inundações na bacia hidrográfica do rio Tejipió, em Pernambuco, Brasil, utilizando o Processo Analítico Hierárquico (AHP), em conjunto com o Sistema de Informações Geográficas (SIG). Para isso, foram elencados seis fatores condicionantes à ocorrência de inundações que foram processados no software livre QGIS (3.10.9), reclassificados e submetidos à álgebra de mapas. Assim, foi possível elaborar o mapa das áreas suscetíveis a inundações para a região estudada, sendo observado que as áreas mais propensas a esse tipo de desastre hidrológico são as densamente urbanizadas e que possuem baixas altitudes e declividades. A utilização desse método, quanto ao objetivo proposto no estudo, se mostrou uma solução vantajosa no tocante à aplicabilidade e viabilidade, possibilitando tomadas de decisões mais assertivas por gestores e profissionais da área.
Use of grape-based stain (Vinatela) on cervical cytology: A Peruvian validation study
Authors: Salazar Moya Jeel , Rojas-Zumaran Victor , Vegas Carlos , Salafia Amalia , Contreras-Pulache Hans
Published: September 2023

Objectives:

The Papanicolaou’s (Pap’s) stain is used for cervical cancer screening. It employs toxic-carcinogenic expensive reagents, which may not be easily accessible to many communities worldwide. The objective of this study was to validate the grape-based alcohol-extracted dye (Vinatela) on normal cervical samples for the Pap test.

Material and Methods:

Samples of the two grape species were collected from two vineyards through the Agroindustrial Research Institute of Universidad Privada San Juan Bautista. The dye extraction from the grape species and the dye performance to stain cells were conducted in three phases: (a) direct staining with pre-fermentation wine products, (b) direct fragmentation of grapes and direct staining with shells of the grapes, and (c) alcoholic extraction of the dye. Vinatela obtained from two species (Vitis vinifera “Tempranillo” and “Malbec”) and posterior staining of cervical samples. We conducted a double-blind validation on 30 cervical samples.

Results:

The basophilic components of the cervical cells were stained. Alcoholic extraction staining protocol had a low yield. The nuclear and cytoplasmic borders, the nuclear details, and the polymorphonuclear nuclei were stained with Vinatela and could be differentiated during nuclear coloration. The initial staining protocol was 10– 20 min × (mean ~12 min) staining time. We noted a slightly better staining with V. v. Tempranillo as compared to V. v. Malbec (P = 0.045).

Conclusion:

Cervical cells stained with Vinatela stain from two grape species cultivated in the Southern of Peru, showed basophilic nuclear details.
Usefulness of the human papillomavirus DNA chip test as a complementary method for cervical cytology
Authors: Lee Rae-Young , Koo Joo-Yeon , Kim Nah-Ihm , Kim Sung-Sun , Nam Jong-Hee , Choi Yoo-Duk
Published: September 2023

Objectives:

As a convenient and economical method of screening cervical cancer and precancerous pathologies, the Papanicolaou smear (Pap smear) has been most widely used. Nevertheless, it requires cytological changes for making diagnoses and reportedly has a high false-negative rate. In this study, the usefulness of the human papillomavirus (HPV) DNA chip test as a complementary method that can compensate for the defect of the Pap smear was investigated.

Material and Methods:

Of the 6516 patients who simultaneously underwent a Pap smear and an HPV DNA chip test at Chonnam National University Hospital between January 2015 and December 2016, 1897, an initial PAP smear-negative patients who had undergone an additional Pap smear during their 2-year follow-up period were selected for this study. Of the subject patients, 281 underwent a cervical biopsy.

Results:

The Pap smear follow-up of an initial Pap smear-negative subjects showed 53 (75.7%) HPV high-risk positive cases in the cytology low-grade lesion group (70 cases) and 46 (97.8%) HPV high-risk positive cases in the cytology high-grade lesion group (47 cases). The 281 biopsy cases included 67 biopsy low-grade lesion cases and 74 biopsy high-grade lesion cases, of which there were 45 (67.2%) and 67 (90.5%) HPV high-risk positive cases, respectively. The follow-up cytology on the high-risk HPV-positive subjects showed that the ratio of their high-grade lesions was 260.8 times greater than that of the high-risk HPV-negative subjects (OR = 260.8 and 95% CI: 36.1 and 1886.1); and their biopsy showed that the ratio of their high-grade lesions was 102.7 times greater than that of the HPV-negative subjects (OR = 102.7 and 95% CI: 14.0 and 753.3).

Conclusion:

The complementary use of the HPV DNA chip test may be useful in increasing the accuracy of screening examinations for the early diagnosis of uterine cervix cancer when combined with the Pap smear.
Application of HPLC in Biomedical Research for Pesticide and Drug Analysis
Authors: Saha Sourav , Mallik Sandip , Debnath Bikash , Singh Waikhom Somraj , Ikbal Abu Md Ashif , Manna Kuntal
Published: September 2023

Compared to traditional liquid chromatography, high-performance liquid chromatography (HPLC) delivers better results for analyzing unknown compounds. It permits faster resolution time, better peak shapes, repeatable responses, and greater precision. A comprehensive literature search has been conducted using online academic databases such as Google Scholar, PubMed, Web of Science, and Scopus, using keywords such as HPLC, pesticide analysis, drugs analysis, chromatographic conditions, and HPLC Column type. Total 75 number of articles were collected from peer-reviewed journals. With the help of literature review we have summarized the chromatographic condition of 30 drug candidates and 27 pesticide candidates. The study’s findings can guide future researchers to understand the chromatographic parameters of drugs and pesticides.
Unleashing the potential of blended learning: An in-depth investigation in Indonesia and Malaysia
Authors: Saputra Setiya Yunus , Muzakki Abdurrohman , Abdullah Khairul Hafezad , Demir Gönül Tekkurşun , Setiawan Edi
Published: September 2023

A limited literature on mixed method research to reveal the effect of blended learning in physical education turn out to be a gap in this research. Therefore, our study aims to investigate the perceptions of teachers about the effects, effectiveness, and challenges of blended learning in physical education classes through mixed-methods research. This study adopted a mixed-methods type with a mixed methods research. There were 12 participants involved in this study, which included elementary school teachers (n=4) and high school teachers (n=4) from Indonesia and elementary school teachers (n=2) and high school teachers (n=2) from Malaysia. The qualitative instrument included in-depth interviews. While, the quantitative instrument used a questionnaire. The qualitative study used statistical analysis with qualitative thematic methods. Meanwhile, in the quantitative study, all responses from 12 analyses were to find the frequency and percentage values of each response. Based on the results of the qualitative study, the majority of teachers perceived that blended learning in physical education classes had a significant effect on the development of students' domains and it was effective to implement physical education learning in elementary schools and high schools. While, results of quantitative study show that the biggest challenges due to the implementation of blended learning in physical education were the lack of technological facilities (86.2%), lack of understanding of teachers and students (72.7%), poor internet connection (64.8%), and limited learning duration in offline classes (50.0%). Therefore, the results of this study are essential and must be evaluated continuously, so that the physical education learning process through blended learning in a sustainable manner can have a positive effect on students at all levels of education in Indonesia and Malaysia or other countries in the world.
ANALISIS RASIO KEUANGAN METODE RBBR DALAM MENGUKUR TINGKAT KESEHATAN BANK PADA BANK UMUM SYARIAH (BUS) PERIODE 2013-2020
Authors: Elsa Elsa
Published: September 2023

This research has a purpose that is: 1. To analyze tha bank’s health level with the financial ratio of the Risk Based Bank Rating (RBBR) method at the BUS period 2013-2020, 2. To determine the difference in the bank’s health level with the financial ratio of Risk Based Bank Rating (RBBR) method at the BUS period 2013-2020. This research uses comparative analysis methods. The classic assumptions used in this research are the normality tes, homogeneous test, while the difference test used the kruskal wallis test. The result of the analysis with the RBBR method indicate that BUS from 2013-2020 has a condition of the bank’s health level in a composite rating of 3 with a value of 64% which means healthy enough, while based on the calculation of different test, seven banks that are used as samples in this study there is a difference from the ratio of NPF, ROA,BOPO and CAR because they have a significant difference of < 0,05 while for the FDR ratio there is no difference from the seven banks because the significant value is > 0,05.
Tailoring Performance of the LiNi0.8Mn0.1Co0.1O2 Cathode by Al2O3 and MoO3 artificial cathode electrolyte interphase (CEI) layers through plasma-enhanced atomic layer deposition (PEALD) Coating
Authors: Zhuang Zilong , Jadhav Vijaykumar , Banitaba Seyedeh , Khademolqorani Sanaz , Gandlar Dayakar , Zhang Fuming , Tan Daniel
Published: September 2023

The Ni-rich layered oxide cathode conceptus has shown high energy density, proper rate capability, and longevity of the rechargeable battery, while poor stability and capacity fading are assumed as its common cons. To address this obstacle, the prospective cathode materials are synthesized by integrating the lithium transition metal oxides with an artificial cathode electrolyte interphase (CEI) layer. Herein, plasma-enhanced atomic layer deposition (PEALD) was employed to coat the LiNi0.8Mn0.1Co0.1O2 (NMC811) configuration with Al2O3 and MoO3. The combined results from morphological examinations revealed the formation of uniform Al2O3 and MoO3 sheets after 200 cycles of PEALD coating. Consistent results from the XRD analysis demonstrate the Al2O3 and MoO3 artificial CEI can reduce the Li-Ni mixing. To shed light on the oxidation-reduction kinetic. The modified NMC811 structures with Al2O3 and MoO3 represented a remarkable improvement in terms of capacity retention. The coated cathode with Al2O3 clearly outperformed the modified configuration with MoO3 with reference to ionic conductivity, charge/discharge reversibility, and capacity retention. The promising results obtained in this study opened possibilities to synthesize the Ni-rich cathodes with boosted electrochemical performance.
Structure-activity relationship studies of arylsulfoxides as reversible monoacylglycerol lipase inhibitors
Authors: Jiang Ming , Huizenga Mirjam , Mohr Florian , Amedi Avand , Bakker Renze , van der Berg Richard , Deng Hui , van der Wel Tom , van Boeckel Constant , van der Stelt Mario
Published: September 2023

Monoacylglyerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it an attractive therapeutic target for a variety of disorders, including inflammation-induced tissue injury and pain, multiple sclerosis and cancer. Previously, we reported LEI-515, an arylsulfoxide, as a peripherally restricted, covalent reversible MAGL inhibitor that reduced neuropathic pain and inflammation in preclinical models without inducing central nervous system (CNS)-mediated adverse effects. Here, we describe the structure-activity relationship (SAR) of arylsulfoxides as MAGL inhibitors that led to the identification of LEI-515. Optimization of the potency of high throughput screening (HTS) hit 1 yielded ± 43 with high potency (pIC50 = 8.5 ± 0.1). However, ± 43 was not metabolically stable due to its ester moiety, which was required for affinity. Replacing the ester group with α-CF2 ketone as a bio-isoster led to the identification of compound ± 74 (LEI-515) as a metabolically stable MAGL inhibitor with subnanomolar potency. LEI-515 is a promising compound to harness the therapeutic potential of MAGL inhibition.
Espionagem e cinema: uma relação paradoxal entre sigilo e propaganda
Authors: Lima de Assis Raquel Anne
Published: September 2023

O objetivo deste artigo é analisar as representações do serviço de inteligência estadunidense no cinema durante a Segunda Guerra Mundial. São analisados três filmes que tinham como foco narrar a atuação da agência Office of Strategic Services (OSS), instituição norte-americana que atuou no serviço de inteligência e espionagem ao longo do conflito mundial. As três películas analisadas são: O.S.S. (1946), Cloak and dagger (1946) e 13 Rue Madeleine (1947). Esses filmes tiveram a participação e o incentivo do OSS em suas produções, em uma parceria com Hollywood, o que possibilita tentar identificar quais os usos políticos que o serviço de espionagem norte-americano fez do cinema. Desta forma, observa-se que entre espionagem e cinema há uma relação paradoxal entre sigilo e propaganda.
O pensamento jornalístico de Albert Camus: crepúsculo do liberalismo tardio europeu
Authors: Rüdiger Francisco
Published: September 2023

Albert Camus se consagrou pelo mundo afora como escritor e ensaísta, mas foi também intelectual público e homem de imprensa. Nosso trabalho foca no segundo aspecto, sublinhando alguns termos do que seria seu pensamento jornalístico. Repórter de jornais em seu país natal, a Argélia, Camus foi, na França, figura maior do Combate, ao final da II Guerra. O presente ensaio considera a trajetória, para esclarecer as concepções jornalísticas subjacentes, desde o ponto de vista doutrinário e histórico. A tese é a de que, anacrônica e utópica à luz das tendências em curso na sua época, a perspectiva camusiana representou em seu país ao mesmo tempo auge e crepúsculo do liberalismo tardio europeu.
A emergência do digital no conflito palestino-israelense e a linha do tempo das estratégias político-comunicativas
Authors: Paschoal Baldin Vitória , Osvald Ramos Daniela
Published: September 2023

O presente trabalho analisa os impactos da emergência das redes de comunicação e informação em rede no conflito palestino-israelense. O objetivo é observar o desenvolvimento histórico das estratégias político-comunicativas associadas à utilização da internet. Para tanto, parte-se da revisão bibliográfica para discutir a utilização das redes digitais por palestinos e israelenses com propósitos de conquistar a opinião pública internacional. Inicia-se com a apresentação dos eventos ocorridos na Guerra do Líbano de 2006 e das revoltas populares árabes de 2010, abordando as primeiras perspectivas de utilização estratégica da internet. Na sequência, são abordados os confrontos em Gaza (2008-2014), discutindo as formas contemporâneas do uso da web 2.0 ao longo de eventos conflituosos.
Assessing the Awareness of EVTM Practices Among Emergency Medicine Physicians in Turkey
Authors: Ege Duygu , Avcil Mücahit , Özlüer Yunus Emre , Yetis Cagac , Sayın Evrim , Şeker Yaşar Kezban , Dinçer Ertuğ
Published: September 2023

Background: Trauma is the leading cause of death in those aged 1–44 years; nearly half of these fatalities are due to bleeding. As resuscitative endovascular balloon occlusion of the aorta (REBOA) and other endovascular resuscitation and trauma management (EVTM) methods became known in Turkey, they started to arouse interest. The main objective of this study is to reveal the impressions of emergency medicine (EM) doctors about EVTM and REBOA application possibilities, and the secondary objective is to determine the issues that are limiting their spread. Methods: We conducted a 22-question cross-sectional survey via e-mail between 1 January and 1 April 2020. The questions were formulated to be closed-ended, semi-closed-ended, and open-ended. The evaluation questions utilized 3- and 5-point Likert scales and Yes/No questions. EM specialists, residents, consultants, and physicians working as emergency department (ED) directors in Turkey were included. EM specialists working in units other than EDs and specialists from other branches were excluded. Results: Among the 512 people contacted for this study, 132 agreed to participate. The numbers of participants that were aware of REBOA and EVTM were 114 and 99, respectively. Participants thought that femoral vascular access, extracorporeal membrane oxygenation (ECMO), and REBOA were more applicable in EDs (median 4, 4, and 4.5, respectively; interquartile range 1–5). Participants considered lack of knowledge and skills and lack of equipment as barriers to REBOA (median 5 and 5, respectively). Conclusions: To disseminate EVTM practices in Turkey, projects should be conducted primarily to address lack of knowledge, skills, and equipment.
RESEARCH OF COST EFFECT OF OPENNESS AND DECK MATERIAL IN SUSPENSİON BRIDGES
Authors: FARHAD Ahmed Ali Abdulqader , KÖKEN Ali
Published: September 2023

Recently, the following rapid development of the national economy and the advancement of communication and transportation, the construction of Long-Span Suspension Bridges have been increasing gradually. Long-Span Suspension Bridges are greatly preferred by engineering designers rather than other bridges equipped with construction supporting systems, not only for economic reasons, but also Long-Span suspension bridges are in the possession of advanced construction techniques when we deal with long distances, for Long-Span suspension bridges acquire supporting constructions features rigged with main cables and ropes. Long-Span suspension bridges are bridge constructions included with cable systems and under strong nonlinear factor effects, which the more the suspension increases, the more the bridges construction lightens, and the more the flexibility grows. There is a lot differences shown in the cost of the Suspension bridges according to different opening. The effect of the deck material is like the effect of the openness. The cost of the suspension bridge in the world is to be discussed too, so the cost is to investigate the effect of opening the drawbridge. The cost of suspension bridges in the world is very controversial, so investigating the financial effect of openness and deck material on suspension bridges is required. In this study, a three-dimensional model of the main cable, suspension rope, deck and tower elements of suspension bridge system by using CSI Bridge Program was constructed and numerical analysis was carried out. The standards used in analysis and design are used the AASHTO LRFD standard, which is common in the world. Suspension bridges of 250, 500, 750, 1000, 1500, 2000 meters were analyzed and designed in different deck material and openings. The material and cost of the suspension bridges have been investigated. The costs according to the openness and deck material of Suspension bridges have been shown by the obtained results.
Factors linked to Kawasaki disease and MIS-C in children with prolonged fever: A retrospective cohort study
Authors: Erdede Özlem , Alkan Kübra , Sarı Erdal , Değrmenci Serpil , Sezer Yamanel Rabia Gönül
Published: September 2023

Background/Aim: Prolonged fever in children presents a diagnostic challenge due to its diverse underlying causes. While infectious diseases historically played a primary role, recent shifts in disease patterns and the emergence of conditions such as multisystem inflammatory syndrome in children (MIS-C) have added complexity. Understanding factors contributing to prolonged fever, particularly the rise in MIS-C and Kawasaki Disease (KD), is vital for accurate diagnosis and timely intervention. This study aimed to identify the etiologies causing prolonged fever in children with temperatures exceeding 38°C for a minimum of 5 days and to examine its relationship with conditions like MIS-C and KD following the coronavirus disease 2019 (COVID-19) pandemic.
Methods: We conducted a retrospective cohort study at a pediatric hospital in Istanbul, Turkey, involving 243 children aged 3 months to 17 years with prolonged fever (>38°C for ≥5 days) between April 2020 and October 2022. We collected data on patient demographics, clinical characteristics, laboratory results, and final diagnoses. The study categorized patients into Group 1 (KD and MIS-C) and Group 2 (other causes). We performed logistic regression analysis to identify factors associated with KD and MIS-C, using hospitalization days and levels of C-reactive protein (CRP), ferritin, and D-dimer. We calculated sensitivity, specificity, and likelihood ratio values and generated ROC (Receiver operating characteristic) curves. The threshold for statistical significance was set at P<0.05.
Results: This study encompassed 243 patients with prolonged fever. The primary causes of admission included infection-related illnesses (60.91%, n=148), MIS-C (18.52%, n=45), and KD (10.70%, n=26). Significant differences were observed in lymphocyte count (P<0.001), CRP level (P<0.001), ferritin level (P<0.001), D-dimer level (P<0.001), hospitalization days (P<0.001), and echocardiographic findings (P<0.001) between the groups. Logistic regression analysis revealed noteworthy associations between the presence of KD and MIS-C and hospitalization days (P=0.001), elevated CRP levels (P=0.018), elevated ferritin levels (P=0.009), and elevated D-dimer levels (P=0.001). Ferritin exhibited an AUC (Area under curve) of 0.737 (P<0.001), and D-dimer demonstrated an AUC of 0.782 (P<0.001) in differentiating between the presence of KD and MIS-C.
Conclusion: The prevalence of infectious and inflammatory conditions remains high in cases of prolonged fever, with a noticeable increase in the occurrence of KD and MIS-C since the onset of the COVID-19 pandemic. Notably, ferritin, CRP, and D-dimer levels are valuable indicators for identifying children at elevated risk of developing KD and MIS-C. While data were collected during the epidemic, additional data collection beyond this period would be necessary.
PENGEMBANGAN PROSES PENGERINGAN OPTIMAL PADA PLANT BIOMASSA PABRIK KELAPA SAWIT DENGAN PEMODELAN ASPEN PLUS V.10.10
Authors: Anjes Laudi M , ZA Nasrul , Sylvia Novy , Ibrahim Ishak , Mulyawan Rizka , Kamar Iqbal
Published: September 2023

Pertumbuhan industri sawit yang tinggi dalam dua decade terakhir menempatkan Indonesia sebagai produsen minyak sawit terbesar dunia. Industri sawit selain menghasilkan minyak nabati, juga menghasilkan limbah padat antara lain serat dan cangkang. Sebagian dari limbah padat ini dimanfaatkan sebagai sumber bahan bakar di boiler untuk menghasilkan uap yang dimanfaatkan untuk pemrosesan dan menghasilkan energi listrik. Paper ini melaporkan hasil kajian simulasi pengaruh rasio serat dan cangkang pada berbagai kondisi udara berlebih terhadap emisi gas hasil pembakaran yang dihasilkan. Penelitian ini menjadi penting mengingat pabrik minyak kelapa sawit ditengarai sebagai salah satu penghasil gas rumah kaca (GRK) dan pemerintah melalui Peraturan Menteri Negara Lingkungan Hidup Nomor 12 tahun 2010 bertekad mengurangi emisi GRK. Perangkat lunak ASPEN Plus (Versi 10.10) digunakan untuk memvariasikan rasio serat : cangkang berkisar 80:20, 75:25 dan 67:33 dengan udara berlebih 90, %, 120% dan 150% di atas kebutuhan stoikiometri. Bahan bakar dialirkan dengan laju tunak ke dalam proses sebesar 1500 kg/jam. Hasil simulasi menunjukkan bahwa kualitas emisi terbaik dihasilkan ketika rasio serat dan cangkang 80:20 dengan udara berlebih sebesar 90%. Pada kondisi seperti ini, gas CO2 yang dihasilkan sebesar 1337 kg/jam, CO 2010 kg/jam, dan NO yang dihasilkan sebesar 0,032 kg/jam . Hasil ini menunjukkan bahwa kehadiran serat di dalam bahan bakar memberikan kontribusi negatif terhadap emisi. Kajian lebih mendalam masih diperlukan untuk meminimalisir limbah padat serat ini untuk digunakan sebagai sumber bahan bakar.
PEMBUATAN BIOETANOL DARI LIMBAH KULIT KOPI SECARA FERMENTASI MENGGUNAKAN RAGI ROTI
Authors: Azrin Mhd , Bahri Syamsul , Nurlaila Rizka , Meriatna Meriatna , Muarif Agam , Fibarzi Wiza Ulfa
Published: September 2023

Bioetanol pada dasarnya adalah etanol atau senyawa alkohol yang diperoleh melalui proses fermentasi biomassa dengan bantuan mikroorganisme. Tujuan dari penelitian ini adalah untuk memanfaatkan limbah kulit kopi yang terbuang di masyarakat khususnya aceh tengah. Metode penelitian menggunakan cara fermentasi dan distilasi dengan variasi waktu fermentasi 2, 4 dan 6 hari. Hasil dari penelitian ini didapatkan kadar bioetanol tertinggi 5,533%, densitas bioetanol tertinggi 0,8324 gr/ml, dan viskositas tertinggi adalah 1,09 cP. Besar dan kecilnya suatu kadar dipengaruhi oleh lamanya waktu fermentasi dan kadar ragi yang diberikan. Nilai densitas dan viskositas dari bioetanol yang didapatkan telah memenuhi Standar Nasional Indonesia.
PERBANDINGAN BIOPOLIMER BERBASIS PATI GLUKOMANAN DAN TAPIOKA SEBAGAI PLASTIK RAMAH LINGKUNGAN DENGAN PENAMBAHAN BEESWAX DAN GLISEROL
Authors: Batubara Diana Putri , Suryati Suryati , Muhammad Muhammad , Meriatna Meriatna , Masrullita Masrullita
Published: September 2023

Tujuan dari penelitian ini untuk memberi pilihan kemasan pada masyarakat unutuk menggunakan kemasan pangan yang bisa langsung dikonsumsi dan ramah lingkungan. Pada penelitian ini dibuat bioplomir berbahan dasar pati alami yaitu pati tapioka dan pati glukomanan dengan penambahan beeswax (1 gr, 2 gr, 3 gr) dan gliserol (1 ml, 2 ml, 3 ml). Hasil dari penelitian ini menunjukkan bahwa penambahan beeswax dan gliserol dapat meningkatkan ketebalan pada biopolimer dimana ketebalan maksimum pada glukomanan sebesar 1,64 dan pada tapioka 0,97 pada konsentrasi pada konsentrasi 3:3 (w:v). Pada derajat pengembungan (swelling) dengan bahan dasar pati glukomanan penambahan beeswax dan gliseol berturut mengalami penurunan dengan  % tertinggi pada nilai 74,928% variasi 1:1(w:v) dan nilai terendah 57,882% variasi 3:3 (w:v) berbanding terbalik dengan pati tapioka nilai % tertinggi pada  86,916 variasi 3:3 (w:v) dan nilai terendah 72,062% variasi 1:1(w:v). Penambahan beeswax pada sampel pati glukomanan dan tapioka dapat mengurangi laju biodegradasi dimana pada pati glukomanan nilai biodegradasi terendah pada 95,560% dan pada pati tapioka 94,248% dengan variasi 3:3 (w:v). Biopolimer dengan bahan dasar pati glukomana lebih optimal mengahasilkan karekteristik  biopolimer sebagai plastik ramah lingkungan dibandingan pati tapioka dengan penambahan beeswax dan gliserol. Pada analisa FTIR menunjukkan gugus yang terkandung pada bioplastik dengan pati glukomanan dan pati tapioka dengan penambahan beeswax dan gliserol  sama dengan komponen penyusunnya yaitu O–H, C–H dan C=O. Kata kunci:  biopolimer, beeswax, drajat pengembungan (swelling), gliserol,                       pati glukomanan, pati tapioka,  plastik ramah lingkungan.
OPTIMIZING NATIONAL HEALTH INSURANCE MEMBERSHIP REDISTRIBUTION TO REMEDIATE THE DELIVERY OF HEALTHCARE SERVICE IN THE BANGLI REGENCY
Authors: Saraswati Putu Yuyun , Widnyana I Ketut , Sudiana A A Ketut , Wiswasta I Gusti Ngurah Nyoman Alit
Published: September 2023

The recent collaboration between the Indonesia Social Security Administrative Body (SSAB) and the Ministry of Health emanated the notion to optimize the National Health Insurance (NHI) membership redistribution program. This latest scheme aims to enable health access comprehensively and improve the healthcare service quality through equal member distribution in the primary care health facilities (PCHF). This was a descriptive study using an evaluation approach, summative, and observational design. A Context, Input, Process, and Product (CIPP) evaluation model was followed to assess the membership transfer redistribution scheme. Data were collected from February to March 2022 through observation, interview, and documentation techniques. Subsequently, the data were then analyzed using the CIPP Evaluation Model and Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis with Focus Group Discussion (FGD). Based on the CIPP evaluation, five and eight PCHFs were executing outstanding (>14,893 or 80.79%) and good level of transferring and receiving scheme practices (11,123 – 14,892 or 60%-79%), respectively. Thus, it could be argued that the membership transferring redistribution procedure has been delivered adequately. Regardless, we still encourage efforts to foster the monitoring and evaluation process. Further, future studies are suggested to include additional evaluation elements to provide a more thorough finding and allow constant membership redistribution program improvement, acquiring the program end goals to the fullest extent.
The Dynamics of Eating Behavior Disorders and the Level of General Psychological Adaptation in Bodybuilding and Fitness Athletes
Authors: Elena Mihaita , Georgeta Mitrache , Marius Stoica , Rocsana Manea Bucea Tonis
Published: September 2023

Knowing the psychological traits and clinically relevant symptoms for the development and maintenance of Eating Behavior Disorders (EDD) in bodybuilding and fitness athletes is a necessity for early intervention and the elimination of stressors that contribute to improving sports performance and quality of life. The aim of the study: To know the dynamics of EDD and the level of general psychological adaptation in athletes who practice bodybuilding and fitness according to sports gender and age. By applying the Inventory of Eating Disorders, EDI-III on 30 participants, bodybuilding and fitness practitioners, aged between 19 and 53, of which 21 are male and 9 are female, psychological traits were investigated relevant (low self-esteem, perfectionism, asceticism, fear of maturity, interpersonal, emotional problems, exaggerated control, and others) in order to know the level of distress and the presence of clinically relevant symptoms for the development and maintenance of EDD (the desire to being thin, bulimia, body dissatisfaction) We concluded that most of the athletes fall within the limits of the threshold values ​​established for the evaluated scales, 30% of the athletes (3 female athletes and 6 male athletes), obtained scores rated above the threshold on at least one of the clinical scales, which means that the risk of EDD is present in some athletes. The average of the investigated psychological scales calculated for the rated scores to establish the level of general psychological adaptation does not exceed the specified threshold for each investigated dimension separately, except for the asceticism, interpersonal problems, and exaggerated control scales. Female athletes have greater psychological balance than male athletes and lower risk of ED than male athletes, important aspects of personality and mental health in psychological training as a screening tool in the process of optimizing the effectiveness of bodybuilding and fitness training.
Infectious diseases prevention policies, strategies and measures: Literature review
Authors: Karamalis Constantinos , Panagopoulou Anastasia , Pattakou Spyridoula , Askoxylakis Michail , Simou Effie
Published: September 2023

Introduction: Throughout the history, infectious diseases have been the most serious cause of morbidity and mortality of the population worldwide, as over the years there have been–and with the development of human activities–many significant outbreaks of infectious diseases. The threats they pose, including their resistance to antibiotics, make the review and development of public health policies a major issue.

Aim: The main purpose of this article is to present most recent policies and strategies on infectious diseases prevention via a literature review and highlight the necessity of developing a holistic approach to the formulation of infectious diseases prevention policies. Moreover, through the most recent literature on this topic it is observed that there is a need to draw up innovative policies, to defend public health and enforce the one health.

Methodology: For this literature review, a research in PubMed database and official organization was conducted and thus a total number (n=28) of articles and handbooks was collected. From PubMed database n1=15 articles were extracted while from websites of official organizations n2=13 was extracted. The final number of references that have been used for this paper was n=33 and were managed by using ZOTERO software.

Conclusion: It is clearly observed that collective work for prevent, and control infectious diseases is mandatory. Also, there is a need for strengthen the already existed public health systems, in order to be well-prepared. A major public health tool is communication, it is very important to communicate strategies and policies to individuals in a proper and comprehensive way.
Construction of structural correlation of quantitative literacy and critical thinking, and factors affecting them in students of pre-service biology teachers
Authors: Arsyad M. , Lestari Sri Rahayu , Sari Murni Sapta , Rohman Fatchur
Published: September 2023

Quantitative literacy and critical thinking skills contribute to the skill of pre-service biology teachers to teach 21st-century learning. This study aims to describe the construction of structural correlation between quantitative literacy and critical thinking skills, and factors affected them among South Kalimantan pre-service biology teachers. The researchers employed a quantitative correlational research method. The samples were 245 biology education students in South Kalimantan province. The instrument used for this study was a test instrument and a questionnaire. The data analysis techniques used were partial least square, structural equation modeling, and Spearman correlation test to evaluate structural models and hypothesis testing. The results of this study indicated that there is a significant relationship between quantitative literacy ability and critical thinking skills of students of pre-service biology teachers in South Kalimantan. There is a significant influence from the factors that affected students’ critical thinking skills and quantitative literacy, except age.
Contribution of squat jump, leg squat, and walking lunge to mawashi geri kicking ability skills
Authors: Indra Siregar Yan , Nurkadri Nurkadri , Rohaya Nirwana , Muda Sory , Alessandro Ginting Delpipo
Published: September 2023

Muscle explosiveness is a physical component that contributes from technical ability to karate ability. The kicking technique in karate is a very important skill in attacking movements. It is necessary to provide training so that muscle explosive power, especially in the legs, increases so that technical ability can increase. Squat jump exercises, leg squats, and walking lunges are forms of exercise that can increase muscle explosive power and the ability of karate kicks. This study aimed to determine the contribution of squat jump exercises, leg squats, and walking lunges to the ability to kick in karate. The subjects of this study were 27 female Karate Dojo athletes, the subject collection technique was total sampling by recruiting all 27 female athletes. The instruments used in this study were for initial and final test measurements using Mawashi Geri's kick ability test. Data analysis using ANOVA test and statistical prerequisite test using SPSS 25. The results of this study from the results of data analysis with a comparative hypothesis test between posttest values showed a calculated t value < a significant level of 0.05, which means that the provision of squat jumps, leg squats, walking lunges significantly contributed to Mawashi Geri's kicking ability. The conclusion of the results of this study explains that leg muscle power training has contributed to Mawashi Geri's kicking ability, especially in walking lunges training the results of the research are very significant.
Robust alarm design strategy for medical devices: Application to air-in-line detection and occlusion management
Authors: Eric Chappel
Published: September 2023

Alarm fatigue in the hospital environment is a recurring problem that can be solved through technical, human, or organizational considerations. The use of technical factors to get a robust alarm management system is illustrated here by two case studies related to air-in-line detection in peritoneal dialysis and insulin pump occlusion management. Air-in-line sensors are usually very sensitive to the presence of small bubbles stuck on tubing and may therefore deliver false alarms. To provide a reliable estimate of the cumulated air volume pumped an IR sensor technology that is insensitive to small bubbles was implemented and tested. Another strategy was used to limit false occlusion alarms in an insulin patch pump. The piezoelectric actuator of this micropump was servo-controlled to the pressure sensor signal to allow insulin to flow into the patient despite the presence of a partial occlusion. The false alarm rate is thus reduced by using a self-adaptive occlusion detection threshold that has been evaluated using numerical simulations.
Improvement of soft soil for road construction on the north brebes tegal ring road project
Authors: Agus Bambang Siswanto  , Usman Wijaya  , Enny Widawati
Published: September 2023

The Brebes-Tegal North Ring Road is a primary arterial road located in the Central Java North Coast (Pantura) corridor that crosses Brebes Regency (12,385 km) and Tegal City (4,715 km), this road was built with the aim of breaking up the traffic congestion that occurred in the City Center of Brebes and Tegal City. In 2010, the construction of the Brebes-Tegal North Ring Road began. However, in 2013 development activities temporarily stopped due to a number of problems, one of which was the condition of the soil at some of the construction sites in the form of swamps and ponds resulting in low soil carrying capacity which affected the construction of roads on it. This condition starts from STA. 8+800 to STA. 17+377 from the direction of Brebes to Tegal. therefore, in December 2019 the project was resumed with a design change to improve the subgrade so that it could withstand the burden of road construction and passing traffic. Soil improvement is carried out using geotextiles, PVD and PHD in the selected soil embankment work process so as to increase the CBR value of the subgrade for the better (higher CBR). In addition, in bridge construction work it is necessary to use pile slabs to prevent high pile failures.