bluuebunny/crossref_metadata_2025 huggingface dataset:
Can mineral equilibrium modelling provide additional details on metamorphism of the Barberton garnet amphibolites?
Authors: Diener J.F.A. , Dziggel A.
Published: January 2021

The Stolzburg domain to the south of the Barberton Greenstone Belt preserves evidence for a 3.23 Ga subduction–collision tectonic event. Garnet amphibolite greenstone remnants have previously yielded conventional thermobarometric P-T estimates of 12 to 15 kbar at 600 to 650°C, 8 to 11 kbar at 650 to 700°C and 7.5 to 8.5 kbar at 560 to 640°C from, respectively, the Inyoni shear zone along the western margin of the Stolzburg domain, the central part of the domain and from the Tjakastad schist belt on the boundary with the main body of the Barberton Greenstone Belt. Pseudosection calculations constrain the stability conditions of the peak metamorphic assemblages at the three localities to be 10 kbar at 675 to 690°C, ~10 kbar at 700°C and ~7 and 10 kbar at 660°C respectively. Although it is possible that the peak metamorphic assemblages may be displaced to somewhat lower conditions if Mn is considered in the calculations, these estimates are generally in good agreement with existing estimates, and confirm that the Stolzburg domain exposes an intact mid- to lower-crustal section that was metamorphosed in a relatively cool environment at 3.23 Ga. Our results do not support previously documented higher-pressure conditions, and we contend that the mineral assemblages used to derive these estimates can equally reflect the conditions determined here. The presence of albite-epidote inclusion assemblages in garnet indicates that the likely prograde path involved a component of heating at depth, which is typical of subduction–collision environments and markedly different from the heating–burial paths expected for sinking greenstones in a vertical tectonic model.
Archaean S-Type granites: petrology, geochemistry and geochronology of the Lekkersmaak and Willie plutons, Kaapvaal Craton, South Africa
Authors: Poujol M. , Jaguin J. , Moyen J-F. , Boulvais P. , Paquette J-L.
Published: January 2021

S-type granites correspond to reworking of pre-existing continental material and form by partial melting of (meta)sediments. Early-to-mid Archaean S-type granites are rare and are more frequently found, usually as relatively small intrusions, during the Neoarchaean and the Archaean-Proterozoic transition. In the context of Archaean geology, their paucity is therefore significant, in that it matches the uncommon nature of processes during this period. In this study, we focus on the Late Mesoarchaean Willie pluton and Neoarchaean Lekkersmaak pluton, which crop out to the south of the Murchison Greenstone Belt in the Northern Kaapvaal Craton, South Africa. These intrusions represent the oldest S-type plutons known so far in the region. We constrain their petrogenesis by documenting their petrology, mineralogy (mineral composition), geochemistry (major and trace elements, Sr, Nd and O isotopes) and zircon U-Pb geochronology. The large Lekkersmaak and smaller Willie plutons represent two granites sharing many geochemical characteristics; they are both peraluminous, Ms-bearing S-type granites although they are more sodic and less potassic than typical S-type granites. The Willie granite was emplaced 2 816 ± 9 Ma ago while the Lekkersmaak yielded an emplacement age of 2 771 ± 2 Ma. Therefore, S-Type magmatism in the area occurred twice at 2.82 Ga and then 40 Myr later at 2.77 Ga, involving comparable immature metasedimentary sources and conditions of partial melting. Finally, a sample from the Lekkersmaak pluton devoid of S-type features as it is muscovite-free and aluminum poor was emplaced 2 734 ± 11 Ma ago. This confirms the episodic nature of magmatic activity south of the Murchison Greenstone Belt.
Composition and Antimicrobial Activity of Essential Oils from Leaves and Twigs of Magnolia hookeri var. longirostrata D.X.Li & R. Z. Zhou and Magnolia insignis Wall. in Ha Giang Province of Vietnam
Authors: Chu Ha Thi Thu , Dinh Thuy Thi Thu , Vu Nam Quang , Nguyen Tam Kieu Bang , Setzer William N.
Published: January 2021

The essential oils from leaves and twigs of Magnolia hookeri var. longirostrata D.X.Li & R.Z.Zhou and Magnolia insignis Wall., growing wild in Ha Giang Province of Vietnam, were obtained by hydrodistillation and analyzed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The respective yields of the M. hookeri var. longirostrata leaf and twig oils were 0.14% and 0.05% (v/w), and of the M. insignis leaf and twig oils were 0.16% and 0.05% (v/w), calculated on a dry weight basis. Major components of the oils of M. hookeri var. longirostrata were: Linalool (21.3%), (E)-nerolidol (12.2%) and neo-intermedeol (13.5%) (leaf oil); 1,8-cineole (13.3%) and linalool (17.1%) (twig oil). Major components of the oils of M. insignis were: Linalool (24.1%), geraniol (14.9%) and (E)-nerolidol (22.5%) (leaf oil); 1,8-cineole (9.5%) and linalool (26.9%) (twig oil). The essential oils from M. insignis showed stronger inhibitory effects on the seven test microorganisms than those from M. hookeri var. longirostrata. Candida albicans and Lactobacillus fermentum were more sensitive to the essential oils than the other tested microorganisms. This is the first time information on essential oils of M. hookeri var. longirostrata leaves and twigs and of M. insignis twigs are reported.
Garīgās nespējas reprezentācija sociālās aprūpes kontekstā Latvijas teritorijā 19. gadsimta otrajā pusē
Authors:   Latvijas Nacionālā bibliotēka, Hermanovska Stella
Published: January 2021

Par pavērsiena punktu speciālās izglītības un sociālās aprūpes vēsturē Latvijā ir uzskatāms 1854. gads, kad Rīgā tika dibināta pirmā iestāde bērniem ar garīgās attīstības traucējumiem. Nozīmīgi tās darbības izpētes avoti ir 1862. gadā izdotais fotogrāfiju albums “Idioten-Anstalt von Fr. Platz: Riga d. 9. Juli” 1862 un ziņojumi par iestādes darbību. Rakstā ir sniegts izklāsts par speciālās izglītības un sociālās aprūpes aizsākumu 19. gadsimtā Latvijas teritorijā (toreizējā Krievijas Impērijā, Vidzemes guberņā) personām ar garīgās attīstības traucējumiem un par to reprezentāciju, pievēršot uzmanību priekšstata radīšanai par sociālo grupu medicīniskā diskursā un medicīnisko tekstu un fotogrāfijas izplatībai informatīvajā telpā ētikas un konfidencialitātes kontekstā. Raksta mērķis ir raksturot nozares institucionālās attīstības aizsākumus un noskaidrot, kā Rīgā pirmās speciālās izglītības un aprūpes iestādes tekstuālā un fotogrāfiskā dokumentācija ir izmantota garīgo traucējumu reprezentācijai no 19. gadsimta otrās puses publicitātes un mūsdienu medicīniskās informācijas konfidencialitātes perspektīvām. Rakstam izvirzītie uzdevumi: 1) apzināt un raksturot Frīdriha un Terēzes Placu darbību speciālās izglītības un sociālās aprūpes institucionalizācijas kontekstā, 2) noskaidrot institucionālās prakses garīgās nespējas diskursu un fotogrāfijas nozīmi garīgās nespējas dokumentācijā un reprezentācijā un 3) salīdzināt medicīniska satura tekstu un fotogrāfiju izplatību informatīvajā telpā ētikas un konfidencialitātes kontekstā no 19. gadsimta otrās puses un mūsdienu skatpunkta, pretstatot pacientu anonimitāti un privātumu ar publisku reprezentāciju.
Power unto Sickness, Sickness unto Power in the Periphery of Soviet Psychiatry
Authors:   Vilnius University, Vaiseta Tomas
Published: January 2021

The three most important processes in psychiatric hospitals of the Lithuanian SSR (1944–1990) have been analysed in terms of the centre-periphery relation. Two of them are named “power unto sickness”, that is, the Soviet state’s efforts to influence people with deviant behaviours who were considered to have “mental diseases”. The first process could be considered external: institutionalisation of psychiatric system in the Lithuanian SSR that was meant to create the conditions, forms and means to exercise the said influence. The main outcome of the process is said to be the so-called “institution addiction” where problems arising from institutionalisation are tackled with more institutionalisation. The second process in the “power unto sickness” category is internal. The Soviet psychiatric model used in the Lithuanian SSR has been analysed and the question whether there has ever been a homogenous and unique model of Soviet psychiatry has been raised. The third process is the symbolic inverse of the “power unto sickness” processes, but determined by them – “sickness unto power”. It shows the “power” itself to be deviant, transgressing formal limits, exposes the consequences and cracks of its exercise. The third process in psychiatric hospitals of the Lithuanian SSR, “parallelisation”, in which the modern hospital, alongside its formal therapeutic function, acquired parallel, non-formal functions, has been described.
Skin manifestations of a new coronovirus infection COVID-19 caused by SARS-CoV-2
Authors: Khryanin Aleksey A. , Sturov Viktor G. , Nadeev Alexander P. , Bocharova Valentina К.
Published: February 2021

The review is devoted to the skin manifestations of new coronovirus infection (SARS-CoV-2), information about which is constantly updated. However, this information has not been systematized yet. The purpose of this review is to analyze the dermatological manifestations of a new coronavirus infection. On average, 12.520.4% of patients with confirmed COVID-19 have developed skin manifestations. The question of whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself remains open at the moment. The possible mechanisms of development of skin lesions and the role of diseases of complement system and blood hypercoagulation in the pathogenesis of the disease are discussed in the article. The review also provides descriptive and clinical examples of skin manifestations in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days, skin manifestations can be an indicator of infection, which leads to the timely diagnosis. In addition, doctors' awareness about skin symptoms associated with COVID-19 infection plays a big role in preventing misdiagnosis of the disease. The authors cite their own clinical сase of a patient with COVID-19 and associated skin angiitis.
Confectionary sunflower: origin, history, structure, breeding directions and features of cultivation technology (review)
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Bochkovoy A.D. , Khatnyansky V.I. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Kamardin V.А. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Nazarov D.А. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK)
Published: January 2021

Analyzing Russian and foreign scientific literary sources we presented data on origin, history, current state and development prospects of the confectionary sunflower. We stated main features of confectionary sunflower compared to oil form. There is described perspective initial germplasm of confectionary sunflower from the VIR collection and collections of the other scientific institutions. We consider different direction of products use, requirements to qualitative and organoleptic traits. We stated an important role of bee-pollination in formation of high seed yields. We think it is reasonable to repurpose step by step breeding works to primary development and introduction of confectionary interline hybrids. The further perfection of scientific and research works with confectionary sunflower according to climatic changes is discussed.
History of sunflower breeding for resistance to broomrape in Russia (review)
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Khatnyansky V.I.
Published: January 2021

The history of sunflower breeding in Russia is permanently connected with breeding for resistance to broomrape (Orobanche cumana Wallr.) – a parasitic plant. The most important task for the scientists was to develop vrieties resistant to broomrape. V.S. Pustovoit, L.A. Zhdanov, E.M. Plachek and other breeders have developed broomrape tolerant sunflower varieties. Their introduction into agricultural production played a huge role in keeping and increasing of sunflower productivity. As evolution of host-plant and parasite develops inseparably, during natural selection of resistant varieties and hybrids there are appeared the new more aggressive races of broomrape which are able to live and multiply. The development of the new aggressive races must be controlled permanently. It can be reached by development of the new resistant sunflower varieties and hybrids.
Three-line hybrid of sunflower Nika
Authors:   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops", Gorbachenko О.F. , Gorbachenko F.I. ,   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops", Gorbachenko V.D. ,   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops", Usatenko Т.V. ,   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops", Luchkin N.S. ,   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops", Zhitnik N.А. ,   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops", Burlayeva Е.G. ,   Donskaya experimental station – a branch of the Federal State Budgetary Scientific Institution “Federal scientific center “V.S. Pustovoit All-Russian Research Institute of Oil Crops"
Published: January 2021

A three-line sunflower hybrid Nika was developed by hybridization of a simple sterile hybrid Donskoy 59 and a line-restorer of pollen fertility ED 155 at the Don experimental station. It is characterized by high productivity, over the years of testing, it exceeded the control on seed yield by 0.25 t per ha, on oil collection per hectare by 0.16 t per ha. According to the length of the vegetative period (98–104 days), it can be attributed to the middle-early group. Plant height is up to 170–180 cm. The leaves are large, the bubbling is very weak, and serration is large. Heads of medium size when maturing turned down with a straight stem. Achenes are broadly ovate, black with grey stripes along the edges and between the edges. The main distinguishing feature of the hybrid is its high productivity and resistance to the new aggressive races of broomrape (E, F, G) and downy mildew (race 330). The hybrid Nika has been included into the State register of protected breeding achievements of the Russian Federation since 2019 and allowed to be cultivated in the Central Black Soil (5), Northern Caucasus (6), Middle Volga (7), Low Volga (8), Ural (9), and Western Siberian (10) regions of Russia.
Economically valuable traits of collected sesame samples tested in the conditions of the Astrakhan region
Authors:   Cis-Caspian Agrarian Federal Scientific Center of the Russian Academy of Sciences (PAFNC RAN), Asfandiyarova М.Sh. , Rybakova Т.P. ,   Cis-Caspian Agrarian Federal Scientific Center of the Russian Academy of Sciences (PAFNC RAN)
Published: January 2021

In 2017–2018, we studied 45 sesame samples from the VIR collection in the experimental fields of the Cis-Caspian Agrarian Federal Scientific Center of the Russian Academy of Sciences (PAFNC RAN). According to temperature indicators, conditions of the years of a research were favorable for the growth and development of sesame. The sum of positive temperatures over the years was equal 3253.8 and 3249.7 °C, respectively. The length of the vegetative period of samples varied from 104 to 133 days. The earliest maturing samples (98–105 days) were KK-80 and 741 from Uzbekistan and K-802 from Tajikistan. As middle-early maturing (106–115 days) 11 samples were characterized, 25 samples were middle maturing (116–125 days), and five samples were late maturing (126–133 days). The most of the samples (33 samples) had seeds of average size (1000 seeds weight of 3.0–3.4 g) at the standard level (3.1 g). By a complex of economically valuable traits we selected 30 samples. The samples KK-883, 291, 171, 265, 468 from Uzbekistan, Azerbaijan, Turkey, Tunisia and Malta demonstrated the highest yield (3.0–4.3 t/ha). Very early maturing samples of sesame with high yields are of great interest and can be used in breeding work.
Universal stand for studying of threshing process of a separate sunflower heads
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Shaforostov V.D. , Makarov S.S. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Kochurov G.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK)
Published: January 2021

While studying the designs of threshing devices and threshing methods, we revealed the main factors that have a significant effecting the threshing process. It has been established that the primary method of seeds threshing is blow with subsequent wiping. Deformation of sunflower heads makes the threshing process easy and reduces seeds damage. When working, all the threshing and separating devices, acting as control objects, are subject to external influences that are caused by numerous and diverse factors requiring constant monitoring and adjustment of the control system. Such factors are moisture, physical and mechanical properties and varietal qualities of the threshed crop. After analyzing the material of the review of copyright certificates and patents, we concluded the new thresher should perform the following operations: compression, vibration, wiping, and blow. The developed stand allows exploring all methods of sunflower heads threshing and studying the impact of each factor on the characteristics of the obtained seed material.
Amino-acid composition of seeds of confectionery sunflower varieties bred at the V.S. Pustovoit All-Russian Research Institute of Oil Crops
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Pomorova Yu.Yu. , Beskorovayny D.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Pyatovsky V.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Serova Yu.M. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Bolkhovitina Yu.S. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Shemet Yu.Yu. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK)
Published: January 2021

Large-fruited hybrids and varieties of confectionery and edible sunflower types are widespread in the production of several countries. The protein quality is of particular importance in the characterization of large-fruited sunflower seeds. The value of a protein complex is determined by its amino acid composition. The value of a protein complex is determined by its amino acid composition. We studied the seeds of three large-fruited varieties of confectionery sunflower: Belochka, Dzhinn, Lakomka, cultivated at the experimental station of V.S. Pustovoit of All-Russian Research Institute of Oil Crops in 2017–2019. We determined the amino acid composition of the seed protein on a HPLC-analyzer Sevko&Co APM1000HT with gradient elution and postcolumn derivatization with ninhydrin. The variety Belochka had the highest content of absolutely dry protein – 21.24 g/100 g, the average protein content for three years was 19.43 ± 0.91 g/100g of absolutely dry matter (ADM), the coefficient of variation was 8.18 %. The protein content of the variety Dzhinn was 19.43 ± 0.11 g/100 g of ADM, the coefficient of variation was 0.78 %. The protein content is more variable in the Belochka variety, while in the Dzhinn variety the oil content is more variable. At the same time, we established that the average values of oil and protein content of these varieties for the years of study are nearly equal. The Lakomka variety has shown stable biochemical parameters for the protein content over two years of cultivation - 17.53 ± 0.15 g/100 g of ADM. There is a strong inverse correlation between the oil content and protein content among the studied varieties, which was r = -0.72. The variety Belochka differs from the other studied varieties. It has the largest amount of essential amino acids (25.48–31.46 g/100 g of absolutely dry matter) and non-essential amino acids (48.33–58.26 g/100 g). The variation of the amino acid content in the Belochka variety was much higher, the coefficient of variation was C = 9–20 %. At the same time, we noted a high homogeneity in protein content (C = 1 %) and amino acid composition (C = 1–15 %) in the Lakomka variety.
The impact of morphometric characteristics of plants self-pollinated sunflower lines on its lodging
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Bochkaryov B.N. , Medvedeva N.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Ryzhenko E.N. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK)
Published: January 2021

We carried out the research in 2018-2019 at the experimental station of V.S. Pustovoit All-Russian Research Institute of Oil Crops. The aim of the research is to study the effect of certain morphometric characteristics of the overground part of plants and the architectonics of the root system on the sunflower lodging. We found significant differences in the architectonics of root systems in 17 maternal lines of sunflower: we identified three morphotypes, differing in the number and thickness of lateral roots of the first and subsequent orders, located in the top soil. We identified the sunflower lines that have a root system with a well-developed main root and many lateral roots of various orders (type A), lines with a normally developed main root and a small number of lateral roots (type B), and lines with a poorly developed main root and few lateral roots in top soil (type C). We identified the presence of both low and high lodging in sunflower lines with different types of root systems. At the same time, there is a tendency towards higher lodging in lines with root system types B and C. The line SL12 3660 showed the maximum lodging resistance during two years of observations. It may be of interest for further work as a possible source of a lodging resistance trait.
Perfil epidemiológico dos pacientes internados por acidente vascular cerebral no nordeste do Brasil
Authors: Barbosa Anderson Matheus de Lima , Pereira Caio Coelho Machado , Miranda João Pedro Rosal , Rodrigues José Hamon de Lima , De Carvalho José Roberto Oliveira , Rodrigues Augusto César Evelin
Published: January 2021

Objetivo: Traçar um perfil epidemiológico dos pacientes com AVC no nordeste do Brasil no período de 2010 a 2019. Métodos: Tratou-se de um estudo retrospectivo, longitudinal, de caráter exploratório e descritivo, além de ser quantitativo. Este estudo se baseou nas informações contidas nos bancos de dados do Sistema de Informações Hospitalares (SIH) e no Departamento de Informática do Sistema único de Saúde (DATASUS) dos casos de AVC nos anos de 2010 a 2019. Resultados: Os resultados revelaram um aumento gradativo da doença durante o período analisado, ocorrendo uma discreta prevalência no gênero masculino (50,8%). Quanto à mortalidade da doença, não houveram alterações bruscas no período estudado, observando-se uma média de 17,74% de mortes por casos. Conclusão: Constata-se, portanto, que é de fundamental importância o assunto abordado neste estudo tanto como fonte de informações epidemiológicas a respeito do AVC no nordeste do Brasil como sendo referência para outras pesquisas cientificas que abordem essa temática.
Perfil sociodemográfico e clínico dos pacientes com lesões agudas e crônicas em atendimento ambulatorial
Authors: Gomes Fabiana de Paula , Galvão Nariani Souza , Albuquerque Aline Duarte
Published: February 2021

Objetivo: Analisar as variáveis sociodemográficas e clínicas em pacientes com lesões agudas e/ou crônicas, bem como os fatores demográficos e clínicos associados à sua ocorrência. Métodos: Pesquisa descritiva, transversal, abordagem quantitativa, realizada com usuários de ambos os sexos, cadastrados em um ambulatório de referência no tratamento de feridas na cidade de Manaus-Amazonas, utilizando-se para a coleta de dados um instrumento com dados sociodemográficos e, outro, chamado Bates-Jensen Wound Assessment Tool (BWAT) para avaliação da cicatrização das lesões. Resultados: Encontrou-se predominância de lesões crônicas, localizadas nos membros inferiores e em pacientes do sexo masculino com presença de comorbidades. Evidencia-se a necessidade de traçar estratégias de prevenção, transformação no estilo de vida e atenção aos fatores de risco preveníveis para essas lesões. Os achados poderão ser equiparados com outros estudos em instituições de referência no Brasil, de modo a fornecer subsídios para as políticas públicas de saúde. Conclusão: O enfermeiro destaca-se como parte fundamental no processo de cura das lesões, portanto, deverá obter entendimento necessário sobre os indicadores sociodemográficas e clínicos relacionados aos pacientes com lesões agudas e crônicas para, a partir deste conhecimento, direcionar sua prática assistencial e educacional.
Ablação por cateter: uma nova opção de tratamento da Fibrilação Atrial Crônica
Authors: Oliveira Estela Fernandes Pimenta , Campos Lays Cristina Oliveira , De Melo Larissa Lemos Pires , Rocha Ana Gabriela Souza , De Lima Danielle Teles , Martins Lara Braga , Borges Larissa Ungarelli , De Rezende Lara Juliana Silva , Hallak Sílvia Avalos
Published: February 2021

Objetivo: Descrever as principais características da fibrilação atrial crônica e apresentar a ablação por cateter como alternativa terapêutica efetiva. Detalhamento do caso: Trata-se de um relato de caso de um paciente com aumento de átrio esquerdo e fibrilação atrial (FA) crônica de difícil controle, que após ser submetido ao tratamento medicamentoso otimizado e posterior cardioversão elétrica sem sucesso, obteve resposta eficiente com ablação por cateter após estudo eletrofisiológico intracardíaco (EEF) e consequente resolução do quadro de FA. O EEF é um método diagnóstico e terapêutico de cateterismo cardíaco, no qual é possível identificar o circuito responsável pela taquicardia e bloquear o foco por meio de uma lesão térmica discreta provocada pelo próprio cateter já inserido, proporcionando a eliminação dos estímulos impulsionadores da arritmia. Considerações finais: O trabalho expõe esta nova alternativa terapêutica, bem como suas vantagens em relação aos tratamentos convencionais já consagrados e a possibilidade de um maior benefício no prognóstico do paciente com FA de difícil controle.
Adaptação de mães à prematuridade: revisão integrativa à luz de Roy
Authors: Dos Reis Paola Panceri , Evers Eliana Coutinho , Mendes Juliana Ollé , Makuch Débora Maria Vargas
Published: January 2021

Objetivo: Apreender na literatura como se dá o processo de adaptação de mães diante da prematuridade do filho à luz dos modos adaptativos de Roy. Métodos: Trata-se de uma revisão integrativa, utilizando a Biblioteca Virtual em Saúde (BVS) e PubMed® como meios de busca dos estudos, tendo como resultando uma amostra de 8 artigos que atenderam aos critérios de inclusão e exclusão de pesquisa. Para análise dos estudos selecionados foi utilizada a Teoria de Roy como referencial teórico. Resultados: Foi possível identificar que a prematuridade tem impacto em todos os quatro modos adaptativos propostos pela Teoria de Roy, que explica a adaptação da pessoa diante de um evento/estímulo que modifica sua vida, sendo maior o impacto nos modos autoconceito e interdependência. Além disso, é possível perceber uma forte ligação entre esses modos, que também servem de mecanismos adaptativos. Considerações finais: Percebe-se que a prematuridade impacta diretamente os quatro modos adaptativos propostos pela Teoria da adaptação de Callista Roy, tendo maior impacto no modo autoconceito, seguido de função de papel e interdependência e, por último, modo fisiológico. Evidencia-se o grande papel do enfermeiro como ferramenta para uma adaptação mais efetiva.
Remdesivir: a eficácia da nova droga no controle do coronavírus da síndrome respiratória aguda grave 2 (sars-cov-2) recentemente emergido
Authors: Rios Diego Lisboa , Andrade Thiago Araújo , Costa Silvia de Siqueira , Torres Paula Margarita Salazar , Da Silva Lucas Roberto , Carneiro Pedro Gontijo , Alves Kerley dos Santos , Marques Welington Ribeiro Aquino , Júnior João Batista Matos , Souza Fabyola Antunes Gonçalves
Published: January 2021

Objetivo: O objetivo do presente estudo foi realizar uma revisão sistemática sobre o efeito do medicamento Remdesivir no tratamento da COVID-19. Métodos: Foi realizada pesquisa no Pubmed e em outras plataformas de buscas pelos seguintes termos: “COVID-19” ou “SARS-CoV-2”, “remdesivir” e “revisão sistemática”. Resultados: Por meio da seleção de 8 artigos para inclusão nesta revisão sistemática, sendo dois deles estudos clínicos de Fase III, randomizados, duplo-cegos e controlados por placebo. Com todas as etapas concluídas, encontraram eficácia de Remdesivir. Entre os dois estudos in vitro, um deles, mostrou que o medicamento possui eficácia na inibição da infecção pelo vírus, enquanto outro complementou mostrando que essa inibição ocorre justamente pela via da qual o Remdesivir é bem conhecido. Por fim, foi identificado o tratamento bem-sucedido com Remdesivir no primeiro caso de COVID-19 nos Estados Unidos. Considerações Finais: A partir dessa revisão sistemática, o uso de Remdesivir é considerado promissor no tratamento da COVID-19. Todavia, outros estudos clínicos precisam ser realizados para comprovar sua eficácia e segurança.
SOSIALISASI DAN PELATIHAN TEKNOLOGI TEPAT GUNA PEMBUATAN EKSTRAK KULIT KACANG METE UNTUK ANTIVIRAL NABATI PADA TANAMAN KEDELAI
Authors: Andayanie Wuye Ria , Ermawati Netty
Published: January 2021

Abstract. Cashew plants is one of the plantation commodities in Indonesia that has high economic value. Cashew nut shell waste can be used as a botanical antiviral for Cowpea mild mottle virus. This activity aims for soybean farmers to be able to provide their own insecticidal at low prices and easily obtained. The method used viz. : 1) an interview and observation, 2) the method of socialization with lectures and discussions or questions and answers; 3) training methods with lecture, demonstrations and direct practice with demoplot. Based on the analysis of community service programs, the following conclusions are obtained: 1) in terms of achievements based on the objectives, substance and efforts of this community service program, it is considered to be very effective in building community independence based on local potential, namely waste originating from cashew nut shells and soybean planting in forest shade area; 2) in terms of the results, benefits and impacts resulting from this community service program are numerous, namely: increasing public awareness to utilize waste originating from cashew nut shell waste for antiviral, increasing community knowledge and skills in the field of processing waste cashew  nut shell for botanical antiviral.

 

Abstrak. Tanaman jambu mete merupakan salah satu komoditas perkebunan di Indonesia yang memiliki nilai ekonomi tinggi. Limbah kulit kacang mete dapat digunakan sebagai antiviral nabati untuk Cowpea mild mottle virus. Kegiatan ini bertujuan agar petani kedelai dapat menyediakan  antiviral sendiri dengan harga murah dan mudah didapat. Metode yang digunakan : 1) wawancara dan observasi, 2) metode sosialisasi dengan ceramah dan diskusi atau tanya jawab; 3) metode pelatihan dengan ceramah dan demonstrasi serta praktek langsung dengan demoplot. Berdasarkan analisis program pengabdian kepada masyarakat, diperoleh kesimpulan sebagai berikut: 1) dari segi capaian sesuai tujuan, substansi dan upaya program pengabdian masyarakat ini dinilai sangat efektif dalam membangun kemandirian masyarakat berbasis potensi lokal, yaitu limbah yang berasal dari kulit kacang mete dan penanaman kedelai di kawasan hutan lindung; 2) Dari segi hasil, manfaat dan dampak yang dihasilkan dari program pengabdian kepada masyarakat ini sangat banyak, yaitu: meningkatkan kesadaran masyarakat untuk memanfaatkan limbah yang berasal dari limbah kulit kacang mete sebagai antiviral, meningkatkan pengetahuan dan keterampilan masyarakat di bidang pengolahan limbah kacang mete untuk antiviral nabati.
Mezuniyet Öncesi Dönemde Aile Hekimliği Eğitim Programı: Uygulamalar, Fırsatlar ve Engeller - Ege Üniversitesi Deneyimi
Authors: DURMAZ Seyfi , TURAN Sevgi
Published: February 2021

Giriş: Birinci basamak sağlık hizmetlerinin geliştirilmesi mezuniyet öncesi tıp eğitimi ile ilişkilidir. Bu çalışmada, bir tıp fakültesinin mezuniyet öncesi döneminde aile hekimliği eğitim programının yürütülmesinde paydaş deneyimlerinin ve görüşlerinin değerlendirilmesi amaçlanmıştır. Gereç Yöntem: Tanımlayıcı tipte olan bu araştırmada fenomenolojik bir araştırma kurgusu nicel verilerle zenginleştirilerek karma desen uygulanmıştır. Ekim 2018–Nisan 2019 tarihlerinde veri toplama süreci gerçekleştirilmiştir. Maksimum çeşitlilik sağlanarak 10 intörn ile iki odak grup görüşmesi, 10 akademisyen ve 8 aile hekimi ile derinlemesine görüşmeler gerçekleştirilmiştir. Görüşmelerden elde edilen nitel verilere içerik analizi uygulanmıştır. Bulguların tanımlanması aşamasında, doğrudan alıntılarla desteklenen veriler bulgular kısmında sunulmuştur. Bulgular: İçerik analizinde ortaya çıkan temalar, dört ana grupta toplanmıştır: Hedefler, programın kapsamı, öğrenme süreci, ölçme-değerlendirme. Hedefler teması kapsamında öne çıkan kodlar; hedeflerin açık ve anlaşılır oluşu, ihtiyaca uygunluğu ve hedeflere ulaşmadır. Programın kapsamı temasında ise; kuramsal dersler ve içeriğin ihtiyaca uygunluğu öne çıkmaktadır. Öğrenme süreci temasında; derse katılım, sahadaki ilişkiler ve saha organizasyonun sağladığı katkı, danışmana ulaşılabilirlik ve sağladığı katkı, hekimlik uygulama dosyası hacmi ve ihtiyaca uygunluğu ve süreci etkileyenler durumlar öne çıkmaktadır. Ölçme-değerlendirme temasında; sözlü ve yazılı geribildirimler, dosya değerlendirmesi, sunumlar ve devam durumu kodları ön plana çıkmıştır. Hedefler konusunda geniş bir uzlaşı olmakla birlikte hedeflerin ihtiyaçlara uygunluğu ve ulaşılması ile ilgili danışmanları “hedeflerin yenilenip geliştirilmesi çabasına açık” olarak tanımlamak mümkündür. Programın kapsamı konusunda öğrenciler ağırlıklı olarak, içeriğin tekrarını eleştirmiştir. Öğrencilerin beklentisi kuramsal yüklemeden çok uygulamaya dönük yöntemlerdir. Öğrenme sürecinde kuramsal dersler için ayrılan süre konusunda paydaşlar uzlaşmaktadır. Yeterlilik ölçütlerinin aile hekimleri dâhil olmak üzere tüm paydaşlar tarafından aynı açıklıkta biliniyor ve uygulanıyor olması önemlidir. Danışmanlar ve aile hekimleri, işyüklerinin eğitime katılımlarının önünde önemli bir bariyer oluşturduğunu vurgularken öğrenciler için de TUS’un benzer etkiyi yarattığını ifade etmişlerdir. Sonuç: Nitelikli bir topluma dayalı eğitim yürütülebilmesi için sağlık hizmet sunucuları ile üniversitelerin tüm paydaşları dâhil edecek bir işbirliği yapması önemli görülmektedir. Çalışma, aile hekimliği uygulamasının halk sağlığı stajı ile entegre uygulandığı bir fakültede katılımcıların olumlu görüşlerin yanısıra uygulamaya dönük önerilerini ortaya çıkarmıştır
EKSISTENSI PARTAI PERSATUAN DAYAK PADA PEMILU 1955
Authors: Prabowo Rikaz
Published: February 2021

This Research aims to describe: (1) Dayak political awakening before election 1955 (2) The struggle PPD in the face of election 1955, (3) Impact PPD post-election victory 1955. This study uses a critical history method. Based on the results of the research can be concluded: first, the political movement of Dayak society, especially in West Kalimantan, began to rise after the proclamation independence of Indonesia with the founding of Dayak In Action (DIA) on 3 November 1945. He was later changed to PPD on 30 November 1946. Secondly, The PPD also conducts consolidation and cadre, maximizing the grassroots potential of the Dayak community, as well as conducting the campaigns in areas.Third, PPD successfully won the 1955 election and occupied strategic positions of government in both the executive and legislative . PPD also sent his deputy for DPR-RI and constituency. In addition, PPD managed to deliver J. C Oevaang Oeray was elected as the Governor of the regional head of West Kalimantan.
PEMBELAJARAN SEJARAH ASIA BARAT KUNO BERBASIS PARADIGMA PEDAGOGI REFLEKTIF
Authors: Printina Brigida Intan , Hasudungan Anju Nofarof
Published: February 2021

Penelitian bertujuan untuk menganalisis perencanaan, pelaksanaan dan evaluasi dalam penerapan Paradigma Pedagogi Reflektif serta memanfaatkan media komik dalam perkuliahan Sejarah Asia Barat Kuno. Metode penelitian menggunakan penelitian kualitatif deskriptif. Data penelitian dikumpukan melalui pengamatan, analisis dokumen dan wawancara dengan mahasiswa di kelas Sejarah Asia Barat Kuno Program Studi Pendidikan Sejarah FKIP Universitas Sanata Dharma Yogyakarta. Pengujian data dilakukan melalui triangulasi data, triangulasi metode, triangulasi peneliti, dan triangulasi teoritis. Penelitian ini menggunakan metode analisis interaktif. Hasil penelitian menunjukkan dengan perencanaan, pelaksanaan dan evaluasi yang benar dalam penerapan Paradigma Pedagogi Reflektif serta media komik yang menarik pada mata kuliah Sejarah Asia Barat Kuno. Maka, mahasiswa mengalami peningkatan pada aspek 3C yaitu, competence, conscience, compassion. Bagi para civitas akademika, hasil penelitian ini diharapkan dapat mengintegrasikan pengajaran dengan penelitian secara maksimal sehingga manfaatnya dapat dirasakan bersama dan mampu dimaknai sebagai salah satu modal pembangunan bangsa.

Kata kunci: Pembelajaran Sejarah, Paradigma Pedagogi Reflektif, Komik, Perguruan Tinggi
Comprehensive Characterization of the Self-Folding Cavitand Dynamics
Authors: López-Coll Ricard , Álvarez-Yebra Rubén , Feixas Ferran , Lledó Agustí
Published: February 2021

The conformational equilibria and guest exchange process of a resorcin[4]arene derived self-folding cavitand receptor have been characterized in detail by molecular dynamics simulations (MD) and 1H EXSY experiments. A multi-timescale strategy for exploring the fluxional behavior of this system has been constructed, exploiting conventional MD and accelerated MD (aMD) techniques. The use of aMD allows the reconstruction of the folding/unfolding process of the receptor by sampling high-energy barrier processes unattainable by conventional MD simulations. We obtained MD trajectories sampling events occurring at different timescales from ns to s: 1) rearrangement of the directional hydrogen bond seam stabilizing the receptor, 2) folding/unfolding of the structure transiting partially open intermediates, and c) guest departure from different folding stages. Most remarkably, reweighing of the biased aMD simulations provided kinetic barriers that are in very good agreement with those determined experimentally by 1H NMR. These results constitute the first comprehensive computational characterization of the complex dynamic features of cavitand receptors. Our approach emerges as a valuable rational design tool for synthetic host-guest systems.
A Rearrangement of Allylic Silanols
Authors: Sathyamoorthi Shyam , Dhokale Ranjeet , Seidl Frederick
Published: February 2021

We show that 1M aq. HCl/THF or NaBH4/DMF allows for demercurative ring-opening of cyclic organomercurial synthons into secondary silanol products bearing terminal alkenes. We had previously demonstrated that primary allylic silanols are readily transformed into cyclic organomercurials using Hg(OTf)2/NaHCO3 in THF. Overall, this amounts to a facile two-step protocol for the rearrangement of primary allylic silanol substrates. Computational investigations suggest that this rearrangement is under thermodynamic control and that the di-tert-butylsilanol protecting group is essential for product selectivity.
A Guide to Water Free Lithium Bis(oxalate) Borate (LiBOB)
Authors: Zor Ceren , Subaşı Yaprak , Haciu Durata , Somer Mehmet , Afyon Semih
Published: February 2021

The use of LiBOB is limited due to slight instability issues under ambient conditions that might require extra purification steps and might result in poorer performances in real systems. Here, we address some of these issues and report the high purity water free LiBOB synthesized with fewer processing steps employing lithium carbonate, oxalic acid, and boric acid as low-cost starting materials, and via ceramic processing methods under protective atmosphere. The physical and chemical characterizations of both anhydrous and monohydrate phases are performed with X-ray powder diffraction (XRPD), Fourier-transform infra-red spectroscopy (FTIR), Raman spectroscopy and scanning electron microscopy (SEM) analyses to determine the degree of the purity and the formation of impurities like LiBOB.H2O, HBO2 and Li2C2O4 as a result of the aging investigations performed. Differential thermal analysis (DTA) is applied to determine the optimum synthesis conditions for anhydrous LiBOB and to analyze the water loss and the decomposition of LiBOB.H2O. Aging experiments with the water free LiBOB are carried out to evaluate the effect of humidity in the phase changes and resulting impurities under various conditions. The detrimental effect of even slightest humidity conditions is shown, and protective measures during and after the synthesis of LiBOB are discussed.
Study on Interface Reaction of BN-Al Composite Materials-ChemRxiv.pdf
Authors: Wang Chao , Dong Mengge , Zhang Lu , Cao Xiaozhou , Xue Xiangxin
Published: February 2021

Ceramic-metal composite materials prepared by the metal infiltration process have become the topic of intense research. The interface reaction between ceramic and metal has an important impact on the mechanical properties of composite materials. This article, for the first time, studies the interface reaction between BN and Al. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were both employed to study interface reaction. Studies have shown that there is an intermediate transition interface between metal and ceramic. The interface reaction between Al and BN produces AlN, and there is no close connection among AlN particles. The grain size of AlN is about 1~2μm. The rate order is: Al element > B element > N element.
Retornantes internos por covid-19: una mirada desde la desigualdad y la informalidad
Authors: Lázaro-Aquino Teódulo Gerardo
Published: February 2021

El estudio tuvo por objetivos: 1) Identificar quiénes fueron los retornantes, 2) Analizar los factores de retorno interno y 3) Explicar tanto las dinámicas como los tipos de retorno. Para ello, se hizo utilizó el método cualitativo de investigación, en su modalidad de diseño narrativo. La principal técnica de recolección de información fue la observación documental (diarios, revistas, webinares, entrevistas en Internet, entre otros). Se concluye en que, si bien hubo elementos coyunturales que favorecieron al fenómeno del retorno como la cuarentena, el aislamiento social, el distanciamiento social y el estado de emergencia, fueron dos los factores estructurales desencadenantes: la desigualdad y la informalidad del país. Asimismo, el desplazamiento de los retornantes por covid-19, una forma de migración forzada, tomaría dos tendencias principales: uno, sería migración de retorno cuando los actores toman la decisión definitiva de quedarse en sus lugares de origen y dos, de reemigración si deciden volver nuevamente a sus destinos de migrantes. Ello depende del tiempo que dure la pandemia, el aislamiento o confinamiento social, el estado de emergencia, pero sobre todo del desenlace que tome la crisis sanitaria, económica y social en curso.
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
Authors: Custódio Tânia Filipa , Paulsen Peter Aasted , Frain Kelly May , Pedersen Bjørn Panyella
Published: February 2021

The human glucose transporters GLUT1 and GLUT3 have a central role in glucose uptake as canonical members of the Sugar Porter (SP) family. GLUT1 and GLUT3 share a fully conserved substrate-binding site with identical substrate coordination, but differ significantly in transport affinity in line with their physiological function. Here, we present a 2.4 Å crystal structure of GLUT1 in an inward open conformation and compare it with GLUT3 using both structural and functional data. Our work shows that interactions between a cytosolic “SP motif” and a conserved “A motif” stabilize the outward conformational state and increases substrate apparent affinity. Furthermore, we identify a previously undescribed Cl− ion site in GLUT1 and an endofacial lipid/glucose binding site which modulate GLUT kinetics. The results provide a possible explanation for the difference between GLUT1 and GLUT3 glucose affinity, imply a general model for the kinetic regulation in GLUTs and suggest a physiological function for the defining SP sequence motif in the SP family.
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
Authors: Itoh Yuji , Iida Shiori , Tamura Sachiko , Nagashima Ryosuke , Shiraki Kentaro , Goto Tatsuhiko , Hibino Kayo , Ide Satoru , Maeshima Kazuhiro
Published: February 2021

Liquid droplets formed inside the cell by liquid–liquid phase separation maintain membrane-less condensates/bodies (or compartments). These droplets are important for concentrating certain molecules and facilitating spatiotemporal regulation of cellular functions. 1,6-hexanediol (1,6-HD), an aliphatic alcohol, inhibits weak hydrophobic protein–protein/protein-RNA interactions required for the droplet formation (droplet melting activity) and is used here to elucidate the formation process of cytoplasmic/nuclear condensates/bodies. However, the effect of 1,6-HD on chromatin in living cells remains unclear. We found that 1,6-HD drastically suppresses chromatin motion and hyper-condenses chromatin in human cells by using live-cell single-nucleosome imaging, which detects changes in the state of chromatin. These effects were enhanced in a dose-dependent manner. Chromatin was “frozen” by 5%, or higher, concentrations of 1,6-HD. 1,6-HD greatly facilitated cation-dependent chromatin condensation in vitro. This 1,6-HD action is distinct from its melting activity of liquid droplets. Alcohols, such as 1,6-HD, appear to remove water molecules around chromatin and locally condense chromatin. Therefore, liquid droplet results obtained using 1,6-HD should be carefully interpreted or reconsidered when these droplets are associated with chromatin.