bluuebunny/crossref_metadata_2025 huggingface dataset:
Tongue Root Configuration of the Apicoalveolar Trill /r/: An Ultrasound Imaging Study
Authors: Rivera Campos Ahmed , Boyce Suzanne E. , Hwu Fenfang , DeMott Brittany N.
Published: July 2022

Common descriptions of articulatory requirements for production of the alveolar trill /r/ mainly focus on describing the configuration of the anterior portions of the tongue, while in contrast, the more posterior parts receive limited attention. Understanding how the posterior portions of the tongue move is vital for understanding speech motor control, especially with regard to speech development. This study used ultrasound imaging of /r/ productions by adult native speakers of Spanish to characterize the contribution of the posterior portion of the tongue to effective production of the sound. The results show that beyond raising the anterior portion of the tongue for trilling, Spanish speakers also retract the back part of their tongue (i.e., the tongue root). This movement resembles that seen for the production of the rhotic English approximant (ɹ). Clinical implications are discussed.
Some (Syn)Gaps are Worse than Others: Deciphering The Role of Syngap Isoforms in Excitatory Synaptic Function
Authors: Gross Christina
Published: July 2022

[Box: see text]
On the Right Trk: Towards an Effective Treatment for Dravet Syndrome
Authors: Wong Jennifer C.
Published: July 2022

[Box: see text]
Dynamic Fluorescence Imaging in Experimental Epilepsy
Authors: Lawlor Patrick N. , Goldberg Ethan M.
Published: July 2022

The ability to develop effective new treatments for epilepsy may depend on improved understanding of seizure pathophysiology, about which many questions remain. Dynamic fluorescence imaging of activity at single-neuron resolution with fluorescent indicators in experimental model systems in vivo has revolutionized basic neuroscience and has the potential to do so for epilepsy research as well. Here, we review salient issues as they pertain to experimental imaging in basic epilepsy research, including commonly used imaging technologies, data processing and analysis, interpretation of results, and selected examples of how imaging-based approaches have revealed new insight into mechanisms of seizures and epilepsy.
A Star is Born: Newborn Astroglia in Epilepsy
Authors: Dang Louis T.
Published: July 2022

[Box: see text]
Early Experience of Undertaking Robotic Assisted Total Mesorectal Excision in Rectal Resections, Avoiding a Diverting Stoma: Key eHancement of the Anastomosis for No Stoma Technique — A Case Series
Authors: Waqas Ahmad , Mykoniatis Ioanis , Sidiqi Najaf , Ahmed Anwar , Stefan Samuel , Naqvi Syed , Harper Mick , Khan Jim
Published: July 2022

Background. Anastomotic leak is a feared complication in rectal cancer surgery, and a proximal diverting stoma to protect the rectal anastomosis is used to minimize its impact. We evaluated a novel technique that uses the da Vinci® robotic platform (Intuitive Surgical) to reinforce the colorectal anastomosis and rectal staple line with sutures, and rectal resection and assessment of the anastomotic perfusion, using our Portsmouth protocol. Methods. During robotic rectal cancer surgery, we used indocyanine green to determine the level of transection and check the vascularity of the circular anastomosis. The distal transverse staple line and circular staple line of the colorectal anastomosis were reinforced with absorbable interrupted stitches (KHANS technique – Key enHancement of the Anastomosis for No Stoma). The integrity of the colorectal/anal anastomosis was also checked using the underwater air-water leak test, with concomitant flexible sigmoidoscopy to visualize the circular staple line. Results. Fifty patients underwent total mesorectal excision for cancer. Using the KHANS technique, we avoided a diverting stoma in all cases. One patient had a radiological leak, leading to a pelvic abscess. In 56% of cases, the anastomosis was within 5 cm of the anal verge. Median length of stay was 5 (3-34) days, with two 30-day readmissions. No 90-day mortality or 30-day reoperations were observed. Conclusion. The KHANS technique appears feasible, successful, and safe in decreasing the incidence of diverting stomas in rectal resections.
The Effectiveness of Preoperative Antibiotic Prophylaxis in Ulnar Nerve Release at the Cubital Tunnel
Authors: Zheng Aaron , Fowler John R.
Published: July 2022

Background:

Although the literature supports not using preoperative antibiotic prophylaxis for clean soft tissue procedures around the hand, there is limited data for soft tissue procedures around the elbow, such as cubital tunnel release. Complications of postoperative infection include scarring, stiffness, and rarely, amputation. The purpose of this study is to determine if preoperative antibiotic prophylaxis decreases the risk of surgical site infection for cubital tunnel release.

Methods:

A retrospective review of 919 in situ, subcutaneous transposition, and submuscular transposition cubital tunnel surgery at a tertiary care center was performed. Patient records were searched to determine preoperative antibiotic status and infection within 30 days of surgery. In addition, comorbidities and demographics such as age, race, sex, and past medical history were also identified. Comorbidities with qualitative variables were analyzed with odds ratio, Chi-squared, and Fisher’s Exact test, linear variables analyzed with t-test.

Results:

There were 5/296 (1.7%) infections in patients without preoperative antibiotics, and 17/623 (2.7%) infections in patients with preoperative antibiotics. Patients who had received preoperative antibiotics had no significant change in infection rate (95% odds ratio: 0.597-1.633). Other variables, such as age, body mass index, race, surgeon, insurance type, diabetes, depression, anxiety, arthritis, concurrent surgeries, and hyperlipidemia were also not significant for risk of infection.

Conclusions:

Preoperative antibiotics do not demonstrate benefit for patients undergoing uncomplicated ulnar nerve releases at the elbow. Preoperative antibiotics do not significantly decrease the risk for postoperative infections in patients, regardless of patient comorbidities. Type of Evidence: Level 4—retrospective study
A Design Framework for Novice Using Grounded Theory Methodology and Coding in Qualitative Research: Organisational Absorptive Capacity and Knowledge Management
Authors: Al-Eisawi Dalia
Published: July 2022

Grounded theory methodology (GTM) is an extensive research methodology that is immensely active in numerous social science research fields. It is by far one of the most popular techniques applied in qualitative research. The challenge in using such methods might appear in their complexity. Several steps of coding and analysis in GTM can be fuzzy and multifaceted for novice researchers specialised in Information Systems (IS) fields, knowledge management, and broad applications of IS. The current study suggests a design framework for novices in qualitative research that presents GTM as a set of techniques characterised graphically, allowing the extraction of grounded results and a set of pragmatic analysed data classifications rather than only concentrating on implementing a grounded “theory”. Hence, the research stresses using the term “grounded techniques”, permitting the creation of grounded categories to strengthen qualitative research results' rigour. The proposed framework meticulously exemplifies how an organised set of phases in a research design can enlighten the novice researcher while conducting a study in knowledge absorptive capacity using a comprehensive GTM process to enforce the understanding of GTM techniques.
Investigation of the clinical effects of acipimox in patients with vulnerable carotid atherosclerosis
Authors: Wu Lin , Huang Weiyi , Liu Xiaoxiao , Yang Baochun
Published: July 2022

Objective

To investigate the clinical effects of acipimox in patients with vulnerable carotid atherosclerosis.

Methods

80 patients with vulnerable carotid atherosclerosis who were admitted to the Department of Cardiology in Wuxi Second People’s Hospital between February 2020 and October 2021 were enrolled in this study. All of these patients were randomly divided into an observation group ( n = 40), who were given acipimox and conventional treatment, and a control group ( n = 40), who were given conventional treatment. The levels of blood lipids and adiponectin (APN), the carotid intima-media thickness (IMT), the area, thickness and number of CAS, peak systolic velocities (PSV) and end-diastolic blood velocity (EDV) of common carotid artery (CCA), and the level of inflammatory markers were measured and compared between the two groups pretherapy and posttreatment. Then, the adverse events were collected and compared between the two groups posttreatment.

Results

The demographics and basic clinical characteristics were not significantly different between the two groups. At posttreatment, the levels of TC, LDL-C, ANP, IL-6, TNF-α and hs-CRP in the observation group were significantly lower than those in the control group at posttreatment. Moreover, the IMT and the area and thickness of CAS in the observation group were significantly lower than those in the control group. After treatment, PSV was lower and EDV was higher in two groups than before treatment; after treatment, compared with control group, PSV in observation group was lower, while EDV was higher. Most importantly, the rate of adverse events was similar in the two groups.

Conclusions

Acipimox reduced the blood lipid levels in patients with vulnerable carotid atherosclerosis. It also stabilized vulnerable plaques and reduced CAS.
The relationship between distributed leadership and teacher well-being: The mediating roles of organisational trust
Authors: Liu Lili , Liu Peng , Yang Hui , Yao Hao , Thien Lei Mee
Published: July 2022

Teacher well-being plays an important role in education reform because it marks teachers’ positive evaluation of and healthy functioning in their work environment. However, there has been insufficient research on the relationship between distributed leadership and teacher well-being and on how organisational trust works as a mediator between these two constructs. Based on responses from 587 teachers in primary schools in southwest China, this study examined how distributed leadership contributes to teacher well-being with attention to the mediating role of organisational trust. Using structural equation modelling and bootstrapping tests, the analysis showed a nonsignificant direct effect between distributed leadership and teacher well-being. Organisational trust and its two dimensions, namely trust in the working team and trust in the principal, had significant mediating effects on the relationship between distributed leadership and teacher well-being. However, the dimension of trust in the work setting did not appear to be a significant mediator. This study contributes to a better understanding of the transferability of leadership theories across cultures and to a deepening comprehension of strategies for improving teacher well-being in Chinese schools and similar contexts. Implications of the study and future research direction are presented.
Cooperation and demotion: A corpus-based critical discourse analysis of Aboriginal people(s) in Australian print news
Authors: Bray Carly
Published: July 2022

Aboriginal and Torres Strait Islander activists and researchers agree that print media discourses surrounding First Nations people(s) in Australia remain negative and stereotypical. However, how these discourses are constructed in language – and therefore linguistic practices which should be avoided – has so far received minimal attention. Analysing a purpose-built corpus of Australian newspaper articles, this study uses the corpus linguistic technique of collocation analysis to identify relevant discourses and examines the linguistic construction of one discourse that had not yet been identified: cooperation. It finds that although notions of cooperation are ostensibly positive (and therefore contrast with discourses identified in previous research), this is often undermined by syntagmatic processes which demote agential Aboriginal participants to prepositional phrases. Prepositions are often neglected in corpus linguistics and in critical discourse analysis, making this an important finding.
Health impact assessment of local policies: methodology and tools
Authors: Mas-Pons Rosa , Caturla-Bastit Mar , Bisbal-Sanz Josep , López-Nicolás Mireia , Barona-Vilar Carmen
Published: July 2022

The aim of this work was to design some tools and a procedure for performing the Health Impact Assessment of municipal policies. A working group made up of municipal and public health specialists from the Valencian Community (Spain) was set up. After reviewing the tools used in other contexts, the Fem Salut? questionnaire for the simplified Health Impact Assessment of regional policies was adapted for use at the local level. A pilot study was carried out in six municipalities and local initiatives promoted by different sectors were analysed. Two workshops were held per municipality (with specialists and with citizens) and participatory techniques were used to identify the possible impacts on the social determinants of health, the population groups more particularly affected and the proposals for improvement. The feasibility of the methodology and the difficulties involved in carrying it out were discussed. A procedure was defined for the Health Impact Assessment of local initiatives in six steps: Describe (the municipality and the project), Extract (screening phase), Co-produce (participatory workshops), Integrate (the scientific evidence with the qualitative information obtained), Disseminate (to politicians, specialists and community) and Evaluate (direct and indirect results) (DECIDE). A guide was developed to facilitate its application at the local level along with two complementary tools (a questionnaire and worksheets). The technical group rated the process as simple and flexible, as well as being easy to adapt to the characteristics of the municipality and project. In addition to the cross-sectoral approach, the incorporation of citizen participation in the process is an important added value.
Tumor Biomarker Testing for Metastatic Colorectal Cancer: a Canadian Consensus Practice Guideline
Authors: Yu Irene S. , Aubin Francine , Goodwin Rachel , Loree Jonathan M. , Mather Cheryl , Sheffield Brandon S. , Snow Stephanie , Gill Sharlene
Published: July 2022

The systemic therapy management of metastatic colorectal cancer (mCRC) has evolved from primarily cytotoxic chemotherapies to now include targeted agents given alone or in combination with chemotherapy, and immune checkpoint inhibitors. A better understanding of the pathogenesis and molecular drivers of colorectal cancer not only aided the development of novel targeted therapies but led to the discovery of tumor mutations which act as predictive biomarkers for therapeutic response. Mutational status of the KRAS gene became the first genomic biomarker to be established as part of standard of care molecular testing, where KRAS mutations within exons 2, 3, and 4 predict a lack of response to anti- epidermal growth factor receptor therapies. Since then, several other biomarkers have become relevant to inform mCRC treatment; however, there are no published Canadian guidelines which reflect the current standards for biomarker testing. This guideline was developed by a pan-Canadian advisory group to provide contemporary, evidence-based recommendations on the minimum acceptable standards for biomarker testing in mCRC, and to describe additional biomarkers for consideration.
30-Second Chair Stand Test Predicts Countermovement Jump Performance in Young Adults
Authors: Alotaibi Mansour M. , Almutairi Marzouq K. , Singh Harshvardhan , Ithurburn Matthew P. , Lein Donald H.
Published: July 2022

Background:

The countermovement jump (CMJ) is a valid and reliable test of lower extremity (LE) muscle power. However, the CMJ may not be appropriate during early-stage rehabilitation of injuries. Functional muscle strength tests (FMSTs) could evaluate LE muscle power with lower joint reaction forces.

Hypothesis:

The lateral step-up test (LSUT), 5 times sit to stand (5×STS), and 30-s chair stand test (30CST) could predict CMJ jump height (JHt) and jump peak power (JPow).

Study Design:

Cross-sectional study.

Level of Evidence:

Level 2.

Methods:

Eighty-one young adults performed 3 CMJs to measure JHt and JPow using an electronic jump mat and speed analyzer. Participants also performed three FMSTs: 1 trial of the LSUT and a modified trial of LSUT touching the ground with the heel only (MLSUT); 2 trials of the 5×STS; and 2 trials of the 30CST, in a randomized order. Spearman rho correlations and hierarchal multiple linear regressions were used to determine whether FMST performances predicted JHt and JPow, after controlling for sex, body height, and body mass.

Results:

30CST, LSUT, MLSUT, sex, body mass, and body height were significantly associated with JHt ( P < 0.05). LSUT, sex, body height, and body mass were significantly associated with JPow ( P < 0.05). Hierarchical regression analyses showed that the 30CST significantly predicted JHt ( P < 0.01) and JPow ( P = 0.03), independent of sex, body height, and body mass.

Conclusion:

30CST performance predicted JHt and JPow in young adults.

Clinical Relevance:

The 30CST is easy to perform, requires equipment found readily in clinics, and predicts LE muscle power. This test could be used to track progress during the early stages of LE injury rehabilitation.
A Case Report of Multiclass HIV Drug-Resistance After an Inappropriate Switch of ARVs with Persistent Unsuppressed Viral Load
Authors: Kakubu Mireille A Mpalang , Kalonji Mukebayi , Katoto Patrick D. M. C.
Published: July 2022

HIV drug resistance is an emerging public health concern; appropriate ART combinations and safe drug switches are prerequisites for achieving virologic suppression. In the early 2000, in Sub-Saharan Africa, accent was mostly on prevention and the scale up of Antiretroviral therapy has just initiated. We report a 46-year-old female who was initiated on ART in 2005 in the private sector, had multiple regimens changes for unclear reasons. Over 7 years (2005-2012), she deteriorated and presented with an AIDS defining condition. A genotyping resistance test (GRT) revealed multiple HIV class resistance and was switched to a third-line ART and improved on treatment. This case report shows that the absence of formal ART guidelines in early 2000, long term exposure to ART and failure to timely switch led to treatment failure and development of multiclass drug resistance mutations identified by the HIV-1 GRT and guided the third-line ART regimen with a successful outcome.
Using Advanced Data to Analyze the Impact of Injury on Performance of Major League Baseball Pitchers: A Narrative Review
Authors: LaPrade Christopher M. , Cinque Mark E. , Safran Marc R. , Freehill Michael T. , Wulf Corey A. , LaPrade Robert F.
Published: July 2022

Major league baseball (MLB) pitchers are at risk of numerous injuries during play, and there is an increasing focus on evaluating their performance in the context of injury. Historically, performance after return to play (RTP) from injury has focused on general descriptive statistics, such as innings or games played, or rate statistics with inherent variability (eg, earned run average, walks and hits per inning pitched, strikeouts per 9 innings, or walks per 9 innings). However, in recent years, MLB has incorporated advanced technology and tracking systems in every stadium, allowing for more in-depth analysis of pitcher-specific data that are captured with every pitch of every game. This technology allows for the ability to delve into the pitching performance on a basis that is more specific to each pitcher and allows for more in-depth analysis of different aspects of pitching performance. The purpose of this narrative review was to illustrate the current state of injury recording for professional baseball pitchers, highlight recent technological advances in MLB, and describe the advanced data available for analysis. We used advanced data in the literature to review the current state of performance analysis after RTP in MLB pitchers after injury. Finally, we strived to provide a framework for future studies to more meticulously assess RTP performance given the current available resources for analysis.
“Merciless Indian Savages”: Deconstructing Anti-Indigenous Framing
Authors: Mackay Ried E. , Feagin Joe
Published: July 2022

In this article, we identify and develop the specific anti-Indigenous subframe of the long dominant larger white racial frame. Using sociological concepts of systemic racial oppression, we show how the anti-Indigenous subframe co-naturalizes race concepts and specific racist language, embedding a deep and lasting negative framing of Native Americans in the U.S. society. We utilize the Google Ngram Viewer for digitized document identification and retrieval, an important social science tool for finding major historical documents for analysis. Using important documents, we identify a very specific language of Indigenous oppression and examine its central role in anti-Indigenous racial framing, past and present. We demonstrate how powerful and influential political, religious, and scholarly figures and major institutions have developed this racist framing over centuries of systemic Indigenous oppression in the United States. Our analysis adds to the body of social science knowledge by explicating how Indigenous oppression on a systemic level has been perpetuated, rationalized, and legitimated by means of a broad white racial frame and its powerful anti-Indigenous subframe.
(Un) Just Deserts: Examining Resource Deserts and the Continued Significance of Racism on Health in the Urban South
Authors: Satcher Lacee A.
Published: July 2022

With concepts like structural racism and social determinants of health currently trending in both academic and public discourse, examining the health consequences of legacies of racism in the built environment is increasingly timely. Resource scarcity in neighborhoods and the emergence of resource deserts in urban cities are critical sources of urban social inequality. As research shows how the sociodemographic makeup of neighborhoods can predict resident access to important material resources like grocery stores, pharmacies, and parks, exploring how this lack of access might impact health is imperative. Employing an environmental justice framework, this study brings together scholarship on environmental racism and stress theory to explore the impacts of spatial inequality on health at the neighborhood level. Using public-use data from the American Community Survey (ACS), Centers for Disease Control and Prevention (CDC), the National Provider Identifier (NPI) registry, and local and state government sources, the author examines the influence of co-occurring resource scarcity (i.e., multiply-deserted areas [MDAs]) on health in neighborhoods across urban cities in the American South. Results indicate that MDAs have higher prevalence of physical inactivity, asthma, diabetes, and obesity compared to neighborhoods with low or no resource scarcity. In addition, across MDAs, neighborhoods that are predominantly Black have higher prevalence of physical inactivity, asthma, diabetes, and obesity relative to nonpredominantly Black neighborhoods. Results also suggest that higher income MDAs have lower obesity prevalence compared with low-income MDAs. Findings contribute to a growing area of literature connecting and examining the structural racism-health connection.
Multimodal urban mobility and multilayer transport networks
Authors: Alessandretti Laura , Natera Orozco Luis Guillermo , Saberi Meead , Szell Michael , Battiston Federico
Published: July 2022

Transportation networks, from bicycle paths to buses and railways, are the backbone of urban mobility. In large metropolitan areas, the integration of different transport modes has become crucial to guarantee the fast and sustainable flow of people. Using a network science approach, multimodal transport systems can be described as multilayer networks, where the networks associated to different transport modes are not considered in isolation, but as a set of interconnected layers. Despite the importance of multimodality in modern cities, a unified view of the topic is currently missing. Here, we provide a comprehensive overview of the emerging research areas of multilayer transport networks and multimodal urban mobility, focusing on contributions from the interdisciplinary fields of complex systems, urban data science, and science of cities. First, we present an introduction to the mathematical framework of multilayer networks. We apply it to survey models of multimodal infrastructures, as well as measures used for quantifying multimodality, and related empirical findings. We review modeling approaches and observational evidence in multimodal mobility and public transport system dynamics, focusing on integrated real-world mobility patterns, where individuals navigate urban systems using different transport modes. We then provide a survey of freely available datasets on multimodal infrastructure and mobility, and a list of open-source tools for their analyses. Finally, we conclude with an outlook on open research questions and promising directions for future research.
Social Buffering is Dependent on Mutual Experience in Adolescent Male Mice Exposed to Social Defeat Stress
Authors: Parise Lyonna F. , Parise Eric M. , Sial Omar K. , Bolaños-Guzmán Carlos A.
Published: July 2022

Background

Individuals who experience emotional, physical, or sexual abuse as children suffer from higher rates of major depressive disorder, drug abuse, and suicide. Early life interventions such as peer support groups can be beneficial to adolescents who experience trauma, suggesting that social support is important in facilitating rehabilitation and promoting resiliency to stress. Although there are some animal paradigms that can model how peer-peer interactions influence stress-reactivity, less is known about how individual stress experiences influence the effectiveness of social buffering.

Methods

The vicarious social defeat stress (VSDS) paradigm allows for the assessment of two different stress modalities, physical (PS) and emotional (ES) stress, which confer different levels of stress with similar biological and behavioral outcomes. Using a modified VSDS paradigm in which pairs of mice experience ES and PS together we can begin to evaluate how stress exposure influences the buffering efficacy of social relationships. Adolescent mice (postnatal day 35) were randomly combined into dyads and were allocated into either mutual experience or cohabitation pairs. Within each dyad, one mouse was assigned to the physically stressed (PS) condition and was repeatedly exposed to an aggressive CD1 mouse while the other mouse was designated as the partner. In the mutual experience dyads the partner mice witnessed the defeat bout (ES) while in the cohabitation dyads the partner was separated from the PS mouse and returned after the 10 min defeat bout was terminated (non-stressed). After 10 days of defeat, mice were tested in the social interaction test (SIT), the elevated plus maze (EPM), and the forced swim test (FST).

Results

PS-exposed mice in the cohabitation dyads, but not those in the mutual experience dyads, showed significantly more avoidance of a novel CD1 aggressor or c57BL/6 mouse, in the SIT. Surprisingly, both partner conditions showed avoidance to a CD1. Interestingly, non-stressed partner mice spent less time in the open arms of the EPM, suggesting increased anxiety; only PS-exposed mice in cohabitation dyads showed more time spent immobile in the FST, indicative of increased learned helplessness.

Conclusions

These data suggest that the efficacy of social buffering can be mediated by individual stress experience.
An Integrative Review: The Evolution of Provider Knowledge, Attitudes, Perceptions and Perceived Barriers to Caring for Patients with Sickle Cell Disease 1970–Now
Authors: Reich Jessie , Cantrell Mary Ann , Smeltzer Suzanne C.
Published: July 2022

Approximately 100,000 Americans have sickle cell disease (SCD). In the USA, the majority of patients with SCD are of African descent. Due to persistent racial and ethnic disparities in healthcare in the USA, patients with SCD experience disproportionately more health inequities because of providers’ implicit biases regarding patient race. Lack of access to health insurance, lack of transportation to healthcare providers, and inadequate provider knowledge contribute to the morbidity and mortality of patients with SCD. The purpose of this integrative review was to analyze and synthesize the literature on providers’ knowledge, perceptions, beliefs, and attitudes toward patients with SCD. A modified (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) method was used to conduct a comprehensive review of the literature yielding 31 publications included in this review. Three connected, yet distinct areas of focus were identified: (1) providers’ knowledge, attitudes, and perceptions of patients with SCD; (2) providers’ perceived or true barriers to caring for patients with SCD; and (3) interventions to improve providers’ attitudes, perceptions, and care of patients with SCD. In each area of focus, research has evolved over time. Also included in this integrative review is a synthesis of measurement instruments used to assess provider knowledge, attitudes, perceptions, and perceived and true barriers to caring for patients with SCD. Adolescents with SCD who are transitioning from pediatric to adult care are at a particularly high risk for morbidity and mortality, so this review focused on the many opportunities that exist to advance the healthcare for young adults with SCD to improve patient outcomes later in life. This includes improving providers’ knowledge, perceptions, beliefs, and attitudes, and lessening the real or perceived barriers to care for patients with SCD.
Sonographic Measurement of Renal Sinus Fat to Renal Cortical Thickness Ratio Is a Better Predictor of Chronic Kidney Disease Than Cortical Thickness Alone
Authors: Schmidt John , Nguyen Peter , Azhar Aaminah , Bender Sean , Ogola Gerald , Ahmed Waqiee , Haberman Amy
Published: July 2022

Objective:

The aim was to determine if the renal sinus fat-to-cortical thickness ratio was a better predictor of chronic kidney disease (CKD) than cortical thickness alone.

Materials and Methods:

A total of 199 patients were included in the study. Renal fat, parenchyma, and cortical thicknesses were evaluated by sonography retrospectively. Same day serum glomerular filtration rate (GFR) values were obtained and correlated.

Results:

The study patients had an average fat-to-cortical thickness ratio <0.4 and had a 63% probability of developing renal failure. The probability increased almost linearly from 65% to 85% for patients with a ratio between 0.4 and 0.5, and then plateaued at 85% probability for a ratio >0.5. Additionally, the average fat-to-cortical thickness ratio was statistically significant ( P-value = .02) in predicting progression to renal failure, compared to a cortical thickness alone ( P-value = .12 and P-value = .39 for the left and right kidney, respectively). However, when evaluating individual kidneys for the average fat-to-cortical thickness ratio, only the left kidney showed a statistical significance ( P-value = .02 and P-value = .08 on the left and right, respectively).

Conclusion:

The renal sinus fat-to-cortical thickness ratio has a significant negative correlation to GFR, specifically for the left kidney. The probability of developing renal failure increases with higher ratios. The renal sinus fat-to-cortical thickness ratio may also be better than cortical thickness alone in predicting progression toward CKD and it acts as an internal control for differences in body size.
Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia
Authors: Niss Omar , Detterich Jon , Wood John C. , Coates Thomas D. , Malik Punam , Taylor Michael D. , Quinn Charles T.
Published: July 2022

Cardiovascular disease is a major cause of mortality in patients with sickle cell disease (SCD). Niss et al previously reported that cardiac magnetic resonance in 25 patients showed universal myocardial fibrosis, which they correlated with increased extracellular volume fraction (ECV). In the current study, they compared patients with SCD who were treated with hydroxyurea or transfusion at age <6 years to a group of patients with SCD without therapy. They documented that patients treated early had ECV levels comparable to normal controls, potentially preventing subsequent myocardial fibrosis.
The safety and efficacy of N8-GP (turoctocog alfa pegol) in previously untreated pediatric patients with hemophilia A
Authors: Male Christoph , Königs Christoph , Dey Sohan , Matsushita Tadashi , Millner Anders Holm , Zak Marek , Young Guy , Kenet Gili
Published: July 2022

N8-GP (turoctocog alfa pegol) is a recombinant, glycoPEGylated, extended half-life, factor VIII replacement product. Here, we examined the immunogenicity, safety, and efficacy of N8-GP in previously untreated patients (PUPs). pathfinder6 is an ongoing, open-label, phase 3 trial that enrolled PUPs with severe hemophilia A and were aged <6 years. The primary end point was the incidence of factor VIII inhibitors (≥0.6 Bethesda units [BU]). Eighty patients received ≥1 N8-GP dose and were included in this analysis; ≥50 patients had ≥50 exposure days to N8-GP. The inhibitor incidence was 29.9% (14.9% high-titer [>5 BU]). Sixty-five patients received N8-GP prophylaxis for an average of 2.17 years with a median annualized bleeding rate (interquartile range) of 1.42 (0.76; 3.13) and a 90.5% hemostatic success rate. Temporarily decreased incremental recovery (IR), defined as ≥2 consecutive measurements of IR <0.6 (IU/dL)/(IU/kg) but no inhibitors, was observed in 17 patients within 5 exposure days to N8-GP and had a strong temporal correlation with anti–polyethylene glycol immunoglobulin G antibody titers. IR returned within the expected range with continued N8-GP dosing. During the period of decreased IR, hemostatic response was similar to that of the overall trial population, and no hypersensitivity related to N8-GP or unexpected new adverse events were reported. N8-GP prophylaxis was efficacious for the prevention and treatment of bleeding episodes in PUPs with severe hemophilia A. The inhibitor incidence was 29.9%. All patients with temporarily decreased IR continuing on N8-GP dosing returned within the expected range and had no evident lack of efficacy. This trial was registered at www.clinicaltrials.gov as #NCT02137850.
Deep learning for de-convolution of Smad2 versus Smad3 binding sites
Authors: Ng Jeremy W.K. , Ong Esther H.Q. , Tucker-Kellogg Lisa , Tucker-Kellogg Greg
Published: July 2022

Background

The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory targets of downstream receptor-regulated Smad (R-Smad) proteins Smad2 and Smad3. However, the lack of Smad-specific antibodies for ChIP-seq hinders convenient identification of Smad-specific binding sites.

Results

In this study, we use localization and affinity purification (LAP) tags to identify Smad-specific binding sites in a cancer cell line. Using ChIP-seq data obtained from LAP-tagged Smad proteins, we develop a convolutional neural network with long-short term memory (CNN-LSTM) as a deep learning approach to classify a pool of Smad-bound sites as being Smad2- or Smad3-bound. Our data showed that this approach is able to accurately classify Smad2- versus Smad3-bound sites. We use our model to dissect the role of each R-Smad in the progression of breast cancer using a previously published dataset.

Conclusions

Our results suggests that deep learning approaches can be used to dissect binding site specificity of closely related transcription factors.
A clinicopathological study of selected cognitive impairment cases in Lothian, Scotland: enhanced CJD surveillance in the 65 + population group
Authors: Kanguru Lovney , Logan Gemma , Waddel Briony , Smith Colin , Molesworth Anna , Knight Richard
Published: July 2022

Background

Variant Creutzfeldt-Jakob Disease (vCJD) is primarily associated with dietary exposure to bovine-spongiform-encephalopathy. Cases may be missed in the elderly population where dementia is common with less frequent referral to specialist neurological services. This study’s twin aims were to determine the feasibility of a method to detect possible missed cases in the elderly population and to identify any such cases.

Methods

A multi-site study was set-up in Lothian in 2016, to determine the feasibility of enhanced CJD-surveillance in the 65 + population-group, and undertake a clinicopathological investigation of patients with features of ‘atypical’ dementia.

Results

Thirty patients are included; 63% male, 37% female. They were referred because of at least one neurological feature regarded as ‘atypical’ (for the common dementing illnesses): cerebellar ataxia, rapid progression, or somato-sensory features. Mean-age at symptom-onset (66 years, range 53–82 years), the time between onset-of-symptoms and referral to the study (7 years, range 1–13 years), and duration-of-illness from onset-of-symptoms until death or the censor-date (9.5 years, range 1.1–17.4 years) were determined. By the censor-date, 9 cases were alive and 21 had died. Neuropathological investigations were performed on 10 cases, confirming: Alzheimer’s disease only (2 cases), mixed Alzheimer’s disease with Lewy bodies (2 cases), mixed Alzheimer’s disease with amyloid angiopathy (1 case), moderate non-amyloid small vessel angiopathy (1 case), a non-specific neurodegenerative disorder (1 case), Parkinson's disease with Lewy body dementia (1 case), and Lewy body dementia (2 cases). No prion disease cases of any type were detected.

Conclusion

The surveillance approach used was well received by the local clinicians and patients, though there were challenges in recruiting sufficient cases; far fewer than expected were identified, referred, and recruited. Further research is required to determine how such difficulties might be overcome. No missed cases of vCJD were found. However, there remains uncertainty whether this is because missed cases are very uncommon or because the study had insufficient power to detect them.
Investigation of the relationship of CO-RADS and CT patterns with laboratory parameters in COVID-19 patients and a new perspective on the total CT scoring system
Authors: Aydin Nevin , Yildiz Pinar , Cansu Döndü Üsküdar , Gündogdu Elif , Mutluay Rüya , Yorulmaz Göknur , Tekin Melisa Sahin , Kocaturk Evin , Alatas İ. Özkan , Kartal Elif Doyuk , Erben Nurettin , Durmaz Gül , Kasifoglu Nilgun , Us Tercan , Sahin Garip , Bal Cengiz , Yilmaz Senay , Korkmaz Cengiz
Published: July 2022

Background

It is important to determine the correlation of the CO-RADS classification and computed tomography (CT) patterns of the lung with laboratory data. To investigate the relationship of CO-RADS categories and CT patterns with laboratory data in patients with a positive RT-PCR test. We also developed a structured total CT scoring system and investigated its correlation with the total CT scoring system.

Method

The CT examinations of the patients were evaluated in terms of the CO-RADS classification, pattern groups and total CT score. Structured total CT score values were obtained by including the total CT score values and pattern values in a regression analysis. The CT data were compared according to the laboratory data.

Results

A total of 198 patients were evaluated. There were significant differences between the CO-RADS groups in terms of age, ICU transfer, oxygen saturation, creatinine, LDH, D-dimer, high-sensitivity cardiac troponin-T (hs-TnT), CRP, structured total CT score values, and total CT score values. A significant difference was also observed between the CT pattern groups and oxygen saturation, creatinine and CRP values. When the structured total CT score values and total CT score values were compared they were observed to be correlated.

Conclusions

Creatinine can be considered as an important marker for the CO-RADS and pattern classifications in lung involvement. LDH can be considered as an important marker of parenchymal involvement, especially bilateral and diffuse involvement. The structured total CT scoring system is a new system that can be used as an alternative.
Autoimmune glial fibrillary acidic protein astrocytopathy presented as isolated area postrema symdrome: a case report
Authors: Dang Jing , Lei Shengsuo , Chen Jihua
Published: July 2022

Background

Area postrema syndrome (APS) as the isolated manifestation in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy has been rarely reported.

Case presentation

A 61-year-old male patient presented with intractable hiccup. He was first admitted to the department of Gastroenterology because he had no symptoms other than hiccup. Then he was diagnosed with possible digestive system disease and started on treatment. 2 weeks later, his symptom didn’t improve at all. After consultation, the patient was referred to our department. Cerebrospinal fluid (CSF) analysis revealed lymphocytes pleocytosis, elevated protein level. Cell-based assays demonstrated GFAP antibodies in blood and CSF. His symptom improved with steroid pulse therapy (methylprednisolone, 1 g for 5 days), followed by a gradual tapering of oral prednisolone. Three months after the initial presentation, he showed no relapses.

Conclusions

We report atypical manifestation of autoimmune GFAP astrocytopathy which presented as APS, suggesting that autoimmune GFAP astrocytopathy should be added to the list of possible cause of APS.
The interactive effects of pre-pregnancy body mass index, thyroid function, and blood lipid levels on the risk of gestational diabetes mellitus: a crossover analysis
Authors: Wang Ying , Lu Sha , Xu Xianrong , Zhang Lijun , Yang Jun , Hu Wensheng
Published: July 2022

Background

Studies have demonstrated the associations between pre-pregnancy obesity, thyroid dysfunction, dyslipidemia, and increased risk of gestational diabetes mellitus (GDM) in pregnant women. This study was designed to investigate whether and to what extent, the interactions between these factors contribute to the risk of GDM.

Methods

A case–control study of 232 GDM cases and 696 controls was conducted among pregnant women from Hangzhou, China. Multiple logistic regression analysis was applied to identify independent risk factors of GDM. Crossover analysis was performed to assess the interactive effects of pre-pregnancy body mass index (pBMI), thyroid hormones, and blood lipid profiles on the risk of GDM. The indexes including attributable proportion (AP) to the interaction and the relative excess risk due to interaction (RERI) were calculated.

Results

Chinese pregnant women with pBMI > 23 kg/m2 (adjusted: OR = 4.162, p < 0.001), high triglyceride levels (> 2.30 mmol/L) (adjusted: OR = 1.735, p < 0.001), and the free triiodothyronine/free thyroxine (FT3/FT4) ratio ≥ 0.502 (OR = 4.162, p < 0.001) have significantly increased risk of GDM. Crossover analysis indicated that there were significant interactions between pre-pregnancy overweight/obesity and FT3/FT4 ≥ 0.502 (AP = 0.550, p < 0.001; RERI = 7.586, p = 0.009), high TG levels and FT3/FT4 ≥ 0.502 (AP = 0.348, 95%CI = 0.081–0.614, P = 0.010; RERI = 2.021, 95%CI = 0.064–3.978, p = 0.043) on the risk of GDM.

Conclusion

The interactions between pBMI and FT3/FT4 ratio, TG level and FT3/FT4 ratio may have significant impacts on the risk of GDM in pregnant women. Such findings may help improve our understanding of the pathogenesis of GDM as well as develop comprehensive strategies for the management of GDM.
Characteristics of picky eater children in Turkey: a cross-sectional study
Authors: Yalcin Suzan , Oflu Ayse , Akturfan Mustafa , Yalcin Siddika Songul
Published: July 2022

Objective

The aim of this study is to investigate the relations of picky eating habit of children with their nutrition, physical activity, screen time and sleep habits in the context of parental picky eating habit.

Methods

In a cross-sectional study a questionnare was applied to the parents of children aged 6–13 years in two provincies. The cases were analyzed as the overall group and the two subgroups in which both parents are not picky eater, and in which at least one parent was picky eater. Child's risk of being picky eater was analyzed by logistic regression.

Results

A total of 913 children and parent pairs were included in the study. The risk of picky eating of the child increases 2.85 (AOR: 1.67–4.88) times when only the mother was picky eater, 5.99 (AOR: 3.32–7.52) times when only the father was picky eater, and 22.79 (AOR: 6.95–74.71) times when both of the parents were picky eaters. In the subgroup in which at least one parent was picky eater, it was determined that children with physical activity duration of ≥ 1 h/day and sleep time of ≥ 9 h /day were less likely to be picky eater and the children with screen time of ≥ 2 h/day were more likely to be picky eaters.

Conclusion

Picky eating habit in childhood is related to the picky eating habit of the parents. In the context of this relationship, the picky eating habit of children is related to sleep, physical activity, screen time and other eating habits.
Pediatric intussusception due to basidiobolomycosis: a case report and literature review
Authors: Aljehani Sameera Mohmmed , Zaidan Tasneem Ibraheem D. , AlHarbi Noora Obaid , Allahyani Bader Hassan , Zouaoui Baha Ridah , Alsaidalan Reham Hamed , Aljohani Saud Mohammed
Published: July 2022

Background

Pediatric gastrointestinal basidiobolomycosis is an unusual fungal infection caused by Basidiobolus ranarum, an environmental saprophyte found worldwide. Typically, basidiobolomycosis presents as a subcutaneous infection or soft tissue tumor-like lesion, and rarely involves the gastrointestinal tract. Gastrointestinal basidiobolomycosis is most common in young infants. It has no definitive clinical presentation, and almost all cases are misdiagnosed during the initial presentation.

Case presentation

We report the case of a 4-year-old Saudi boy who presented to the emergency department with abdominal pain, nausea, vomiting, and weight loss. Ultrasonography revealed a target sign. Based on the ultrasonography findings, surgery was performed, which revealed the presence of intussusception. Eventually, the patient was diagnosed with intussusception secondary to intra-abdominal basidiobolomycosis based on the histological findings. The patient was readmitted and intravenous voriconazole therapy was initiated. One week after the second admission, the patient developed abdominal pain, nausea, vomiting, inability to hold down food, and constipation. Computed tomography of the abdomen was suggestive of small bowel obstruction, which was managed conservatively. The patient responded well and was subsequently discharged with a prescription of oral voriconazole.

Conclusions

This case reveals that gastrointestinal basidiobolomycosis can cause intussusception. This report will inform clinicians of the importance of considering gastrointestinal basidiobolomycosis in the differential diagnosis of chronic abdominal pain in children, even in the absence of fever or a clinically obvious abdominal mass, especially in countries such as Saudi Arabia, where cases have been reported.