bluuebunny/crossref_metadata_2025 huggingface dataset:
Anesthesia management in patients with neurological diseases: an updated systematic review
Authors: Fayad Mohamed , Alnahdi Abdulmajeed , Bakor Abdullah , Bosaeed Mohammed , Hawsawi Ammar , Alsenadi Yasser
Published: December 2022

Prior literature discouraged anesthesiologists from administering regional anesthesia on patients with pre-existing neurologic disorders. Anesthesiologists are occasionally faced with adopting a regional anesthetic method in patients with pre-existing neurological diseases. There is uncertainty about whether secondary variables such as patient characteristics and anesthetic and surgical risk factors might influence the post-operative neurological outcome. To review the current literature on the anesthetic management of patients with neurological diseases. Studies related to our subject were explored using PubMed and Google scholar databases. The keywords included were "Anesthesia, anesthetic management, neurological disease, regional anesthesia," and were used in various combinations. The inclusion criteria were original studies that reported Anesthesia management in patients with neurological disease and full text- articles. A total of 100 articles were obtained, only 8 articles were eligible for the inclusion criteria were published between 2004 and 2021. The detailed studies were conducted on 156 participants, two of them were case series, and six were case reports. Patients with central nervous system (CNS) problems such as multiple sclerosis (MS), amyotrophic lateral sclerosis, Tuberous sclerosis, and brain tumors were included in our study. General anesthesia has been associated with worsening MS. A bupivacaine-based scalp nerve block and Dexmedetomidine were used as the primary hypnotic-sedative medicine to perform awake craniotomies on 10 patients, allowing safe tumor removal. The study shows that the risks associated with neuraxial anesthesia and analgesia in those with pre-existing CNS illnesses may be less prevalent than previously thought.
Value Of Anteroposterior-To-Transverse Ratio in Ultrasonic Diagnosis of Thyroid Nodule in Different Locations
Authors: Zheng Hai-Ning , Wang Wei Wang, MD , Wang Xiao-Qing Wang, MD , Song Wen-Jing , Song Wen-Jing , Zhao Rui , Li Meng , Wen Chao-Yang Wen, MD
Published: December 2022

Purpose: To investigate the value of anteroposterior-to-transverse ratio (ATR) and the effect on features of nodules in ultrasound (US) diagnosis of thyroid nodules in different locations. 
Methods: The nodules were divided into three groups according to the different nodule location: isthmus group; upper and lower poles of bilobed thyroid group; and the middle of the bilobed thyroid group. The diameters of the nodules were recorded, and ATR of the nodule was calculated on the transverse and longitudinal sections. The transverse and the longitudinal sections of ATR of thyroid nodules in different groups were compared. 
Result: The transverse section of ATR was significantly different among the three groups (p = 0.001). In addition, there are significant differences in many US features among three groups, including nodule composition, thyroid parenchyma, morphology, echogenicity, shape, calcifications, vascularity, nodule ACR TI-RADS and histopathologic (all p < 0.05). In the group of upper and lower poles of bilobed thyroid, significant difference was found between the transverse and the longitudinal section of ATR (p = 0.019). The cut-off values of transverse section and longitudinal section of ATR were 0.967 and 0.750, respectively. 
Conclusion: The transverse section of ATR at different location of thyroid may be a predictor for malignancy with clinical diagnostic significance.
Changes in Vector Astigmatism After Superotemporal Versus Temporal Clear Corneal Incision Cataract Surgery
Authors: Zhao Zhennan , Fan Qi , Jiang Yongxiang , Lu Yi
Published: December 2022

Purpose: To investigate vector and refractive astigmatism changes after superotemporal versus temporal clear corneal incision cataract surgery.
Methods: Patients were diagnosed with age-related cataract with corneal astigmatism < 1.5 diopters (D) and were divided into two groups: superotemporal incision (R group) and temporal incision (L group). Uncorrected visual acuity, manifest refraction, corneal topography, anterior segment optical coherence tomography was performed pre- and six months postoperatively. Total ocular astigmatism, corneal astigmatism, vector of surgically induced corneal astigmatism (SICA), non-corneal ocular residual astigmatism (N-CORA), postoperative intraocular lens decentration and tilt were analyzed. 
Results: Thirty-eight subjects were included: 21, R group; 17, L group. After surgery, the N-CORA decreased significantly from 1.17±0.72 D to 0.73±0.47 D in all patients (P=0.001), 1.03±0.52 D to 0.70±0.40 D in the R group (P=0.005) and 1.35±0.90 D to 0.78±0.55 D in the L group (P=0.033). Significant differences between t:he R and L groups were found in the postoperative meridian of anterior corneal astigmatism (75.95±52.50 vs 116.79±47.29; P=0.017), total corneal astigmatism (51.65±42.75 vs 95.20±57.32; P=0.011), J45 change vector of SICA in the anterior cornea (-0.10±0.18 vs 0.00±0.11; P=0.048) and total cornea surface (-0.14±0.17 vs 0.03±0.12; P=0.001). 
Conclusion: The N-CORA decreased significantly after cataract surgery. Superotemporal and temporal incisions caused differences in the meridian components of oblique astigmatism in some patients but did not have a significant effect on the magnitude of corneal astigmatism.
Analysis Of The Association Between Sh2B1 chr16.28884655 And Type 2 Diabetes
Authors: Liu Jingjin , Cao Renjun , Li Dewei , Miao Fang , Yang Ping an , He Hui , Yu Han , Zhang Xiang , Qin Jie , Yang Yanlan
Published: December 2022

Purpose: To determine correlation between genetic susceptibility of type 2 diabetes mellitus (T2DM) and Src homology 2 B adapter protein 1 (SH2B1) gene polymorphism in a diabetic population. 
Methods: A total of 111 T2DM patients (DM group) and 34 healthy controls (NC group) from Shanxi Provincial People’s Hospital were included in this study. Exon 9 of the SH2B1 gene was detected using the Sanger sequencing method, and the relationship between SH2B1 gene polymorphism and diabetes was analyzed. 
Results: Comparison of the data between the two groups showed that the values of TG, the updated HOMA of insulin resistance (HOMA2-IR), weight, body mass index, waist circumference, fasting blood glucose and fasting insulin levels of the DM group were higher than those of the NC group (P < 0.05). The HOMA2 insulin sensitivity (%S) of the DM group was lower than that of the NC group (P < 0.05). Sequencing analysis revealed that the following five single nucleotide polymorphisms in exon 9 of SH2B1 may be related to T2DM: rs181578610, rs550079240, chr16.28884655, chr16.28884659 and chr16.28884831. Among them, chr16.28884655 was found to be significantly related to diabetes; this site, located on the NM_015503 exon, was related to TG, LDL-C and waist circumference.
Conclusion: The SH2B1 gene locus chr16.28884655 was found to be significantly related to genetic susceptibility to T2DM.
Hats Off to the CIM Reviewers Of 2022
Authors: Bortolussi Robert
Published: December 2022

For over 40 years the journal of Clinical and Investigative Medicine (CIM) has published articles of interest to clinician investigators in Canada and elsewhere. We strive for the highest standards and to remain relevant to our readers, but we cannot achieve this goal without the help of our reviewers, all of whom play a vital role in maintaining the integrity of the scientific process. Without their efforts, academic excellence would falter.
6ᵗʰ INTERNATIONAL SYMPOSIUM “SMART LION”. MEDICINE AND WAR, OCTOBER 14, 2022
Authors: Bekesevych Anna , Pavlovskyi Yaroslav , Hresko Natalia
Published: December 2022

On October 14, 2022, the 6ᵗʰ International Symposium “SMART LION” (Science Medicine Arts Research Translational Lviv International Opportunity Network) was held in Lviv with the support from Danylo Halytsky Lviv National Medical University, the Medical Commission of the Shevchenko Scientific Society, Lviv City Council and Lviv Conference Bureau. It was no coincidence that the time of the conference coincided with the Day of Defenders of Ukraine, which include military medical professionals and scientists who equip them with knowledge and skills enabling them to save lives on the battlefield.

The purpose of the symposium was to analyze the new experience of medical professionals and volunteers of Ukraine and its allies, which they acquired during russia's war against Ukraine, develop new methods in medical education, and establish close cooperation between military medical professionals, volunteers, and scientists.

The scientific event was held online via ZOOM. It was also streamed on the Facebook page of the journal “Proceedings of the Shevchenko Scientific Society. Medical Sciences”. The event featured more than 20 speeches by international and domestic scientists and highly qualified specialists. Subsequently, they will serve as a scientific and practical foundation for the development of both military and general medicine. Discussions during the conference clearly showed the need for systemic changes in medical education, supplementing educational programs taking into account the vast experience of military medical professionals, and improving teaching methods.

At the end of the symposium, organizers expressed confidence that most of the deliverables and ideas highlighted during the conference will be successfully implemented. We sincerely thank all defenders and allies of Ukraine, volunteers and medical professionals who save people's lives, sometimes pulling them out of the death grip. With hope for and belief in a bright future, with faith in an upcoming victory and plans to meet again live in Lviv at SMART LION 2023.
SENSORY GATING: BALANCE BETWEEN SLEEP AND LIFE
Authors: Coenen Anton
Published: December 2022

Sleep is a state of the brain characterized by a low level of vigilance and diminished consciousness. The reaction to external stimuli and the processing of stimuli are attenuated in sleep. During sleep, the reticular thalamic nucleus inhibits at the thalamus the flow of sensory activity from the senses to the cerebral cortex. After arrival at the afferent layer of the primary cortex, the reduced sensory flow is analyzed and personalized by layers of the cortical area and transferred by the corticofugal system back to appropriate subdivisions of the thalamus. Thalamic subdivisions target the information of the senses to related areas of the cerebral cortex, where the messages can be (sub)consciously perceived. When necessary, the sleeper can be awakened by a wake-up call, either by stimuli indicating danger or by personally meaningful stimuli. Evidently, sensory gating in sleep has two main features. First, it is favorable for sleep, by reducing the cerebral brain activity through the reticular thalamic nucleus, and second, it is necessary for the sleepers' safety and well-being, by analyzing the preserved activity on essential or dangerous external elements by the corticofugal system. These two features are analyzed in detail in non-REM sleep as well as in REM sleep. In the latter type of sleep, the process of sensory gating is almost similar to non-REM sleep, despite the enigmatic reconstruction of external stimuli into the dream. With the extended corticofugal system, sleep phenomena as the first-night effect, the occurrence of local sleep and wake states, as well as the unihemispheric sleep are comprehensible.
MENINGOCOCCAL INFECTION: A BRIEF REVIEW AND PERSONAL OBSERVATIONS OF THE GENERALIZED FORM OF THE DISEASE IN THREE-MONTH-OLD TWINS
Authors: Prokopiv Oleksandra , Lysheniuk Svitlana , Segedii Lidia , Karmazyn Halyna
Published: December 2022

Meningococcal infection in the form of sporadic cases or minor group outbreaks, mostly among children, is registered in all countries of the world. The disease has a wide range of clinical manifestations – from an asymptomatic bacterial carriage and acute nasopharyngitis to the rapid development of meningococcemia, acute meningococcal sepsis and meningitis. The article highlights and summarizes literature data related to the incidence of meningococcal infection, ways of infection, features of the clinical course of the disease in the newborn period, and modern views on the problem. A rare clinical case of the development of severe generalized forms of meningococcal infection in 3-month-old twins with a fatal outcome in one child is described. The decisive role in the development of the disease of twins is determined by the way and duration of children’s contact with their father, who has a bacteriologically confirmed (Neisseria meningitidis, biovar C) meningococcal nasopharyngitis. Early diagnosis and treatment of all forms of meningococcal infections are important to prevent the development of GMI. The key method of MI prevention is vaccination.
AN EXPLORATORY STUDY OF PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS TO IDENTIFY SIMPLE, ROBUST AND RELEVANT BIOMARKERS FOR THERAPEUTIC INTERVENTIONS FOR PTSD: STUDY RATIONALE, KEY ELEMENTS OF DESIGN AND A CONTEXT OF WAR IN UKRAINE
Authors: Serhiyenko Viktoria , Holzmann Klaus , Holota Serhii , Derkach Zenovii , Nersesyan Armen , Melnyk Stanislav , Chernysh Oleksandra , Yatskevych Ostap , Mišík Miroslav , Bubalo Volodymyr , Strilbytska Olha , Vatseba Bohdana , Lushchak Oleh , Knasmüller Siegfried , Cherkas Andriy
Published: December 2022

Introduction. The incidence of post-traumatic stress disorder (PTSD) is increasing due to war in Ukraine is of growing importance as this disorder is a serious risk factor for alcohol/drug abuse, depression, suicide and functional dysregulation of internal organs, in particular cardiovascular, endocrine, immune systems. PTSD can also lead to social inadaptation in family and at work. This makes PTSD a very important social problem in Ukraine that causes significant economic damage, since most of the PTSD patients are young and in working age.

Objectives. The purpose of this paper is to describe the rationale, key elements of design, methodology and future prospects of the ongoing project “Exploratory study of health related physiological and biochemical parameters to identify simple, robust and relevant biomarkers for therapeutic interventions for PTSD patients”.

Methods. Short time ECG records (5 minutes in supine position and 6 minutes in orthostatic test) recorded by “CARDIOLAB” (Kharkiv, Ukraine) digital ECG device with software to analyze HRV was used to calculate time-domain and frequency-domain parameters of HRV.

Results. The pattern of HRV changes indicates suppression of parasympathetic activity, low overall spectral power and dominance of sympathetic branch of autonomic nervous system in participants with PTSD.

Conclusions. PTSD has no effective treatment so far and the best clinical practices rarely reach efficacy of 50%. The realization of the exploratory clinical study described in this paper will provide insights in the mechanisms underlying systemic consequences of PTSD and will build the evidence enabling clinical trial(s) for studying treatment intervention for patients with PTSD.
ASSESSMENT OF RISK FACTORS FOR DEVELOPMENT OF BIRTH DEFECTS AMONG NEWBORNS IN LVIV REGION IN 2002-2020 (PART 1)
Authors: Hnateiko Oleh , Kitsera Nataliya , Henyk-Berezovska Sofia , Lukyanenko Nataliia , Hruzyntseva Nataliya
Published: December 2022

Introduction. The frequency of children with birth defects (BD) according to the WHO reaches 4-6% of the total number of newborns.

Objectives. The purpose of this work was to determine the probable risk factors for “model” BDs in newborns.

Methods. Analysis of clinical-epidemiological and medical-statistic data from the primary documentation on newborns in 2002-2020 with BDs by the “case-control” method filling out registration cards in maternity hospitals of Lviv region was conducted.

Results. There were filled 1204 healthy newborns’ cards and 1211 cards of newborns with BDs. In the structure of “model” BD, the deformations of the musculoskeletal system composed 272 (22.5%) cases, clefts of the lip and palate accounted for 193 (15.9%) cases, chromosomal abnormalities comprised 174 (14.4%) cases. We observed statistically significant risk (р<0.05) of BDs for newborns with increased numbers of pregnancies in mothers. There was a statistically significant difference [OR=3.97; 95%CI: 1.97; 7.99] in the medical history relative to stillbirths (3.2%) in mothers with BD newborns as compared to women in the control group (0.8%). The prevalence of pathological structure of the placenta in women of the study group (32.8%) was higher [OR=3.71; 95%CI:3.01; 4.56] than in those of the control group (16.8%).

Mothers of both groups showed no statistically significant difference in anemia, preeclampsia, the interval between pregnancies, and the number of abortions and miscarriages (p> 0.05).

Conclusions. Further research in this area should be directed to determine the contributions of genetic factors in BD occurrence, considering the genealogical history of each family.
Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi
Authors: SAKALLIOĞLU Ahmet , AKARAY İrfan , KAYA Sultan , KAYA Özlem , KÖSE Gizem , GARİP Rüveyde , GUCLU Hande
Published: December 2022

Amaç: Diyabetik retinopati (DRP) hastalarında sağlıkla ilişkili yaşam kalitesini (SİYK) etkileyen faktörlerin araştırılması.

Gereç ve Yöntemler: Çalışmaya tip 2 diyabet nedeniyle DRP açısından takipli 400 hastanın 800 gözü katılmıştır. Hastalar oftalmolojik muayene sonrasında Kısa Form-36 (SF-36) anketini doldurmuştur. SF-36’ya göre fiziksel işlev, fiziksel rol, bedensel ağrı, genel sağlık, canlılık, sosyal işlevsellik, duygusal rol ve ruh sağlığı, fiziksel ve zihinsel bileşen özet ölçümleri hesaplandı. Hastaların demografik özellikleri hasta dosyalarından not edilmiştir. İki bağımsız grubu karşılaştırmak için normal dağılım varsayıldığında bağımsız örneklemlerde T-testi, verilerin normalliği reddedildiğinde Mann-Whitney U testi kullanıldı. İkiden fazla olan bağımsız grupların karşılaştırılmasında Bonferroni veya Tamhane’s T2 düzeltmeli ANOVA testi, sayısal değişkenler arasındaki ilişki Pearson korelasyon testi ile değerlendirildi. Anlamlılık düzeyi p
Vitamin and Micronutrient Deficiency and Peripheral Polyneuropathy Following Intragastric Balloon Technique Used For Obese People: Preliminary Study
Authors: GÜLER Sertaç Ata , GÜREŞİN Alican , ONBAŞILAR Umut , ŞİMŞEK Turgay , KAYA ÇELİK Handan , UTKAN Nihat Zafer , CANTÜRK Zafer
Published: December 2022

Aim: Complications from malnourishment when treating obesity are common, especially following bariatric surgery. Peripheral polyneuropathy due to vitamin and micronutrient deficiency is the most commonly encountered complication of bariatric surgery. The objective of this study was to investigate if this technique may lead to peripheral polyneuropathy due to vitamin B1, B2, B6, B12,folate, zinc, iron, and copper deficiency.

Material and Methods: In this study nine patients whose obesity was treated with the Spatz3 intragastric balloon technique wereinvestigated for vitamin and micronutrient deficiencies and any consequent peripheral polyneuropathy. Vitamin B1, B2, B6, B12,zinc, copper, iron and folate were measured. Electromyography (EMG) was used to evaluate peripheral polyneuropathy, based on the Toronto Clinical Neuropathy Score (TCNS).

Results: None of the patients had vitamin B1, B2 or B6 deficiency, whereas one patient (11%) had vitamin B12 and another one patient (11%) had folate deficiency. Copper deficiency was seen in five patients (55.6%), iron deficiency was seen in seven patients (77.8%) and zinc deficiency was seen in eight patients (88.9%). Two patients (22.2%) had abnormal sensory nevre velocity and were diagnosed with polyneuropathy. However, these two had normal concentrations of B vitamins and folate but were deficient for copper, iron, and zinc.

Conclusion: The intragastric balloon technique does not appear to be associated with peripheral polyneuropathy due to vitamin B deficiency. In our opinion it is a safe approach for obesity treatment in terms of the risk of peripheral polyneuropathy due to vitamin B deficiency.
The Relationship Between Long-Term Glycemic Control and Partial Remission in Type 1 Diabetes: A Retrospective Study
Authors: CİMBEK Emine Ayça , BEKFİLAVİOĞLU Semiha , KARAGÜZEL Gülay
Published: December 2022

Aim: Partial remission (PR) is a significant period in the early course of type 1 diabetes (T1D) with implications for diabetes management. We aimed to investigate whether long-term hemoglobin A1c (HbA1c) outcomes in T1D differed as a result of experiencing PR. We also analyzed the demographic and clinical factors that may influence long-term glycemic control.

Material and methods: We retrospectively tracked the HbA1c values of 131 children and adolescents with T1D over a 5-year period. Patients were stratified into low (
VI. ZONGULDAK ENDOKRİN GÜNLERİ III. ENDOKRİNOLOJİK HASTALIKLARA MULTİDİSİPLİNER GÜNCEL YAKLAŞIM KONGRESİ BİLİMSEL PROGRAM, SÖZLÜ VE POSTER BİLDİRİLERİ
Authors: BAYRAKTAROĞLU Taner , KARADENİZ ÇAKMAK Güldeniz , TOPALOĞLU Ömercan , BALBALOĞLU Hakan
Published: December 2022

Zonguldak Bulent Ecevit Universitesi Merkez Farabi Kampusu Tahir Karauğuz Konferans Salonu ve Sezai Karakoc Kultur Merkezi’nde, Prof.Dr.Taner BAYRAKTAROĞLU ve Prof.Dr.Güldeniz Karadeniz ÇAKMAK’ın Kongre başkanlıklarıyla, 20 Eylul – 24 Eylul 2022 tarihlerinde “VI. Zonguldak Endokrin Gunleri, Endokrin Hastalıklara Multidisipliner Guncel Yaklaşım Kongresi (https://zeg.beun.edu.tr/)” gercekleştirildi.

Kongre oturumlarındaki olgu sunumlarının, sözlü bildirileri ve poster bildirileri ozetlerinin sunulması amaçlanmıştır. Kongre suresince iki ayrı oturumda toplam 16 sözel bildiri ve poster bildirisi yapıldı. Boylece, Kongrede gercekleştirilen endokrin hastalıklara guncel yaklaşımın bilim dunyası ile paylaşılması sağlanmıştır.

Anahtar Sözcükler: Zonguldak Endokrin Gunleri, Endokrin Hastalıklar, Multidisipliner Yaklaşım, Kongre
Constitutional Amendment Procedures in the World and Suggestions for Vietnam
Authors: Giang Vu Le Hai
Published: December 2022

The Constitution, which has the highest legal effect, stipulates the most important and fundamental principles of the political regime, the organization of state power, human rights and fundamental rights of citizens. Therefore, amending the constitution is not only a serious legal event, which significantly affects the legal system in general, but also affects many aspects of social life. The constitutional amendment procedure shall be difficult and complex to avoid arbitrary change as well as be applicable and feasible to process. Guaranteeing this balance is not easy, and vary in different historical circumstances. This explains why the constitutional amendment procedure is still an important and preferred subject in legal studies though it is not a new issue. This article focuses on studying some basic theoretical issues about the constitutional amendment and constitutional amendment procedures in the world; on this basis, this article makes some recommendations for constitutional amendment procedures in Vietnam.

Keywords: Amending constitutions, making constitutions, constitutional review.
Clases, grupos e individuos en Colombia
Authors: Luna Benítez Mario
Published: December 2022

El lector encontrará textos sobre la vida campesina, en la llamada “nueva ruralidad”, como el texto de Emilia Pietrafesa (UNICAMP) sobre la vida individual y familiar del sertão brasileiro, desarrollándose entre campo y ciudad; como el texto de Maite Yie (Pontificia Universidad Javeriana) sobre las luchas recientes de los campesinos nariñenses en búsqueda de un nuevo reconocimiento estatal y de apoyo para la reproducción de sus vidas productivas; o bien, marcando la presencia de la pauta de la condición étnica, el texto de Fernando Urrea, José María Rojas, Jairo Castaño y Luis Gabriel Quiroz (todos de la Universidad del Valle), quienes presentan los datos demográficos, socioeconómicos y culturales de las sociedades indígenas de tres municipios del norte del Cauca. También encontrará el lector ponencias referentes a diversos grupos sociales urbanos, trazados por características sociológicas, como la condición urbana de los comerciantes indígenas en Bolivia, presentada por Juliane Müller (Universidad de Múnich), la de Jean Paul Sarrazin (UdeA) sobre los grupos formados por las nuevas religiosidades, o la de Jeanny Posso (Universidad del Valle), que expone los estilos de vida de grupos urbanos de población negra en Cali, y, en otro sentido, la ponencia de Leidy González (Universidad La Gran Colombia) y Helena Restrepo (Universidad del Rosario) sobre los efectos de la filantropía estatal en grupos pobres de Bogotá de la población capturada por sus programas económicos. Igualmente, se incluyen las ponencias sobre las clases medias, entre las que se destaca la conferencia de Kathya Araujo (Usach sobre el caso de Chile, que explora las formas de definición sociológica de sus grupos medios y de su crecimiento; así comotambién los relevantes estudios en poblaciones negras, de los que da expresión, primero, el texto de Dieter Neubert (Universidad de Bayreuth, Alemania) sobre la diversidad de las clases medias africanas, el caso de Kenya; segundo, el enriquecedor texto de Mara Viveros (UNAL) que nos conceptualiza y define el impacto del multiculturalismo en los grupos profesionales negros.
EFEK ALIRAN NON DARCY PADA DESIGN HYDRAULIC FRACTURING DI RESERVOAR PERMEABILITAS RENDAH
Authors: Kabisat Ari Febriana , Setiati Rini , Prakoso Suryo
Published: December 2022

Lapangan Z merupakan lapangan Gas yang terletak di cekungan Kutai, Kalimantan Timur. Karakteristik reservoar gas pada lapisan G memiliki permeabilitas rendah (0.05 – 10 mD) sehingga memerlukan stimulasi hydraulic fracturing (HF) untuk mencapai produksi yang ekonomis. Terdapat fenomena terkait dengan laju alir produksi yang tinggi pada rekahan sumur gas yang mempengaruhi konduktivitas rekahan dan kinerja produksi sumur. Salah satu fenomena tersebut adalah pengaruh aliran non-Darcy yang perlu diperhatikan dalam perencanaan desain HF. Pada penelitian ini dilakukan perhitungan dan analisis pengaruh non-Darcy terhadap produktivitas sumur gas. Pendekatan optimalisasi desain HF mengunakan kombinasi metode Unified Fracture Design dengan analisis keekonomian Net Present Value  terhadap variasi massa propant untuk mendapatkan NPV yang maksimal. Hasil penelitian menunjukan efek aliran non-Darcy mengakibatkan panjang rekahan menjadi lebih pendek dan lebar rekahan menjadi lebih besar, permeabilitas efektif rekahan berkurang sekitar 2 – 4 kali lipat, laju alir produksi gas menurun sekitar 21-37 % dan  kumulatif produksi sekitar 21-37 %  dibandingkan hanya menggunakan asumsi aliran Darcy. Hasil sensitivitas NPV terhadap massa proppant menunjukan NPV maksimal didapatkan dengan massa proppant optimum sebesar 130.200 lbm di sumur N-1, massa proppant 125.000 lbm di sumur N-2, dan massa proppant 105.000 lbm di sumur N-3.
TUMBUH KEMBANG BAYI DENGAN LABIOGNATOPALATOSCHIZIS
Authors: Setiati Dita , Shafira Nisa
Published: December 2022

Tujuan  dari penelitian ini adalah untuk mengetahui pertumbuhan dan perkembangan anak dengan labiognatopalatoschizis. Labiognatopalatoschizis, biasa disebut dengan sumbing bibir  dan lelangit merupakan kelainan wajah yang paling umum terjadi pada semua populasi dan etnik di seluruh dunia. Kami laporkan kasus bayi laki-laki lahir cukup bulan dengan labiognatopalatoschizis bilateral tanpa kelainan kongenital lainnya,  merupakan kasus yang jarang ditemui. Faktor risiko saat antenatal yaitu terpapar asap rokok selama kehamilan, ibu mengalami stres dan kelelahan akibat kerja sehingga terdapat abortus iminens. Bayi dengan gangguan pada faktor intrinsik genetik heredokonstitusional sumbing bibir dan lelangit bilateral dapat tumbuh dan berkembang secara optimal sesuai usianya. Peran serta orang tua yang sangat besar secara aktif sebagai bagian dari ekosistem mini serta penyedia kebutuhan bio-psikososial anak sehingga kebutuhan asuh yaitu nutrisi, imunisasi, pengobatan dapat terpenuhi. Bayi mendapatkan penanganan optimal sejak dini, pemasangan obturator sementara memberikan output yang baik. Pada kasus ini adalah bayi laki-laki dengan labiognatopalatoschizis dilakukan tindakan labioplasty dan rhinoplasty dilakukan saat usia 4 bulan. Saat ini bayi sudah makan nasi tim dengan lauk telur, hati, sayur tanpa tersedak. Imunisasi bayi lengkap sesuai usia. Sebagai pemenuhan kebutuhan asih dan asah, orang tua memberi kasih sayang, berkomunikasi serta stimulasi  sesuai usia perkembangan bayi. Kunci keberhasilan penanganan bibir sumbing dan lelangit adalah menata laksana yang baik secara multi-disiplin,  dokter anak, dokter bedah, termasuk bedah umum, bedah plastik, bedah mulut, serta dokter Telinga Hidung Tenggorok–KL, bayi dapat penangananan maksimal, terhindar dari infeksi diharapkan bayi dapat tumbuh kembang  optimal.
UJI KLINIS : EVALUASI KEJADIAN MATA KERING SETELAH OPERASI FAKOEMULSIFIKASI MENGGUNAKAN KUESIONER DEQ-5
Authors: Adiwardhani Anggraeni , Amalia Husnun , Prasetyaningsih Noviani , Kartadinata Erlani
Published: December 2022

Mata kering (dry eye) dapat mengganggu penglihatan dan gangguan aktifitas sehari-hari. Kejadian mata kering pada usia >60 tahun adalah 26,2%. Pada usia >60 tahun juga akan terjadi perubahan pada lensa yang disebut katarak senilis, dengan presentase 96%. Tatalaksana untuk katarak senilis berupa operasi katarak, yang salah satunya dilakukan dengan metode fakoemulsifikasi. Operasi katarak yang dilakukan akan dapat menginduksi perubahan terutama dalam hal sensitivitas kornea, perubahan tersebut dapat memicu timbulnya mata kering.Tingginya kejadian mata kering pada lansia dan operasi katarak yang saat ini banyak digunakan adalah fakoemulsifikasi, maka peneliti tertarik melakukan penelitian untuk menilai pengaruh operasi fakoemulsifikasi terhadap kejadian mata kering.

Tujuan: Menilai faktor yang mempengaruhi kejadian mata kering paska operasi fakoemulsifikasi dan menganalisa hubungan kejadian mata kering setelah operasi fakoemulsifikasi. Manfaat penelitian untuk meningkatkan derajat kesehatan mata pada lansia.

Metode: Eksperimental, dengan populasi pasien penderita katarak yang melaksanakan operasi fakoemulsifikasi. Tehnik sampling dengan konsekutif non random sampling. Kriteria eksklusi tidak menggunakan tetes pelembab sebelum operasi fakoemulsifikasi dan tidak menderita penyakit kronis.

Hasil: Karakteristik dan faktor resiko berupa : Jenis kelamin perempuan (52,9%), Umur <65 tahun (60,6%), Tidak memiliki Riwayat Diabetes Melitus (86,5 %), Tidak merokok (76%), Tidak memiliki Diabetes Melitus (89,4%), Tidak dry eye pre operasi (61,5%), Tidak dry eye post operasi (82,7%).

Simpulan: Tidak ada karakteristik maupun faktor risiko yang berhubungan dengan kejadian mata kering post operasi fakoemulsifikasi. Hubungan yang signifikan terjadi antara kejadian dry eye pre operasi dan post operasi pahkoemulsifikasi dengan p=0,03.
GANGGUAN PENDENGARAN AKIBAT PAPARAN TOLUEN
Authors: Ridwan Alvin Mohamad , Lestari Ade Dwi
Published: December 2022

Gangguan pendengaran umumnya dikaitkan dengan penuaan, paparan kebisingan, trauma kepala, dan obat-obatan ototoksik. Tetapi semakin banyak bukti yang juga menghubungkan gangguan pendengaran dengan paparan bahan kimia di lingkungan kerja. Pekerja ditempat percetakan mempunyai risiko tinggi terkena gangguan pendengaran dalam pekerjaannya, hal ini disebabkan zat Toluene yang memiliki efek neurotoksik yang dapat mengakibatkan gangguan pendengaran hingga tuli. Beberapa penelitian telah menunjukan bahwa paparan toluene dan bising dapat menyebabkan gangguan pendengaran. Kombinasi pelarut kimia ototoksik dan juga bising dapat memperburuk gangguan pendengaran. Gangguan tersebut menyebabkan kerusakan pada outer hair cell pada organ corti, sehingga menyebabkan tuli sensorineural , paparan toluene sendiri juga dapat menyebabkan gangguan pada Susunan Saraf Pusat, Sistem Pernafasan dan lain-lain. Pasien yang mengalami tuli sensorineural memerlukan penanganan perhatian khusus dikarenakan mempunyai prognosis yang buruk dalam perbaikan maupun kekambuhannya. Tatalaksana yang diberikan mungkin dapat mencegah atau menghambat perburukan namun tidak memperbaiki kerusakan yang sudah terjadi
Analisis Karakteristik Demografis Dan Lama Penggunaan Kosmetik Terhadap E-WOM Dan Keputusan Pembelian Merk Emina di Kota Semarang
Authors: Sari Listyorini  , Kusuma Araafiona Chandra
Published: December 2022

Kosmetik saat ini menjadi komoditi yang sangat dibutuhkan oleh wanita yang menunjang penampilan sehari-harinya. Sebagai kebutuhan primer wanita tentunya industry kosmetik mendorong kompetisi semakin tinggi salah satunya Emina sebagai brand local kosmetik di Indonesia. Brand local tentunya tidak mudah dalam menempati posisi teratas dibanding brand impor. Dengan demikian kemampuan E WOM dalam mempengaruhi keputusan pembelian sangat penting dengan memperhatikan karakteristik demografi konsumen di Indonesia. Penelitian ini bertujuan untuk mengetahui pengaruh E WOM terhadap keputusan pembelian dengan moderasi dari karakteristik demografi dan lama penggunaan. Penelitian ini menggunakan sampel sebanyak 100 responden yang berdomisili di Semarang Jawa Tengah. Penelitian ini dilakukan dengan cara menyebarkan kuesioner secara langsung dan kuesioner dalam bentuk google form. Alat analisis yang digunakan dalam penelitian ini adalah analisis WarpPls. Hasil penelitian menunjukkan bahwa E WOM berpengaruh signifikan terhadap keputusan pembelian, lama penggunaan kosmetik memiliki pengaruh signifikan sebagai pemoderasi antara E WOM dan keputusan pembelian, karakteristik demograsi yaitu usia dan tingkat pendapatan berpengaruh tidak signifikan dalam memoderasi hubungan antara E WOM dan keputusan pembelian. Kosmetik Emina perlu mempertimbangkan peran pengalaman terbarik dari konsumen sebagai pengguna kosmetik lokal karena dengan pengalaman, konsumen dapat memberikan informasi terbaik kepada orang lain. Pengalaman ini dapat diaplikasikan dalam bentuk strategi produk dan harga yang lebih baik daripada sebelumnya.

Kata Kunci: E WOM; Karakteristik demografi; lama penggunaan kosmetik; keputusan pembelian
On Navigating Paranoia, Repair, and Ambivalence as Crip Pandemic Affects, Or, I’m So Paranoid, I Think Your COVID Test Is About Me
Authors: Pandya Jiya
Published: December 2022

How do my 'hermeneutics of suspicion' color this current crisis? In this auto-theoretical essay, I reflect upon the blend of judgment, suspicion, and paranoia that have settled into my body-mind this past year, and how these feelings shape my engagement with people, institutions, and systems. I have been taught that 'judgment' is an essential aspect of immigrant and crip safety. Recently, it has become my (crip)epistemology, and I cannot decide whether this is for better or worse. On the one hand, suspicion is productive. It has kept me and my loved ones alive in a time of deliberate death. On the other, it frustrates, disrupting my capacity for connection. I check my temperature constantly, I hear the guilt in my voice when my family in India tell me they have not left the apartment in months, I spend precious time with friends calculating their risk relative to mine, I go to protests but am afraid of the consequences of my solidarity. Drawing on Eve Sedgwick's essay on paranoid reading practices, Patricia Stuelke's Ruse of Repair, Sianne Ngai's work on ugly feelings, Nikolas Rose's analyses of somatic ethics, and Mel Chen's theory of racialized toxins, I explore the modalities that paranoia has both enabled and disabled for me. I examine my ambivalent relationship with repair—some reparative practices like mutual aid sustain queer/crip/immigrant community while others like cure constrict our lives. This piece aims to tease out the tensions latent in crip worldmaking between suspicion and generosity, public health and communal care, and paranoia and repair.
The Queer Aut of Failure
Authors: Cavar [sarah]
Published: December 2022

I, a Mad, autistic, multiply-disabled person, began my PhD in Cultural Studies in September of 2020. I started to make my home in graduate school during the COVID-19 pandemic, fully online, and I've excelled, calling into question normative assumptions of in-person socialization, education, and collaboration as superior to their virtual counterparts. In this article, I reflect on the cripistemic pedagogies of failure that facilitated a neuroqueered and transMaddened transition to Zoom-based graduate life. I will also consider email, text messages, and video calls as equalizing mediums in which both formal and fugitive spaces can open for queercrip collaboration across borders, timezones, and access needs. Lastly, I will tell the stories of technological 'failures' that I have experienced—miscommunications, failing internet, time delays—as generative possibilities rather than indictments of a non-normative learning. Necessarily imperfect and rife with humorous, intriguing, and profoundly human failures, as well as surprising and generative openings, pandemic education has ushered in new queercrip, transMad, ways of knowing and teaching that have uniquely benefitted me. Far from a circumscribed or lacking educational landscape, I argue, post-COVID academia is filled with pedagogical and epistemological openings, holes through which new disabled and Mad scholars, myself included, can make ourselves a beautifully imperfect home space. I invite you inside.
assembly required
Authors: Schlauderaff Sav
Published: December 2022

This piece stitches and layers together a mix of photographs, poetry, and reflections to tell a story—my story—of c-PTSD, grief, (chosen) family, and my constant yearning to exist fully as myself.
Review of Remembering Our Intimacies: Moʻolelo, Aloha ʻĀina, and Ea by Jamaica Heolimeleikalani Osorio (University of Minnesota Press)
Authors: Kushi Makana
Published: December 2022

Jamaica Heolimeleikalani Osorio foregrounds the intimate in aloha 'āina, a Kanaka Maoli conception of caring for land, or that which feeds. She provides a close reading of the classic Hawaiian epic 'Hi'iakaikapoliopele' alongside contemporary Kanaka Maoli battles with settler colonialism and heteropatriarchy. Osorio engages the uniquely Kanaka Maoli genre of moʻolelo by modulating seamlessly between the interpersonal and structural, analysis and composition, and the nineteenth century and the present day.
Review of How to Go Mad without Losing Your Mind: Madness and Black Radical Creativity by La Marr Jurelle Bruce (Duke University Press)
Authors: Miller Liz
Published: December 2022

'How to Go Mad without Losing Your Mind' offers a poignant study of what author La Marr Jurelle Bruce calls 'mad methodology,' extending care and consideration to Black artists historically, fictionally, and contemporaneously rendered mad by oppressive anti-Black capitalist discursive practices. Reflecting on the creative practices of Buddy Bolden, Nina Simone, Lauryn Hill, and Dave Chappelle, among others, Bruce provides a clear-cutting analysis of the ways normative cultural logics work to figure Black art and protest as inherently mad.
“Revolution of Thought and Action”: W. E. B. Du Bois’s World Search for Abolition Democracy
Authors: Obst Anthony
Published: December 2022

In recent years, scholars and activists have brought renewed attention to W. E. B. Du Bois's concept of abolition democracy. Initially coined in Black Reconstruction (1935), to describe both a political movement and a democratic ideal, abolition democracy has been taken up theoretically by Angela Davis, Allegra McLeod, and others to describe the ongoing process of dismantling global capitalism's political, racial, gender, and economic hierarchies, alongside the simultaneous creation of reconstructed social relations, institutions, and practices governed by universal democratic participation, instead of by force. This article suggests that Du Bois continues to draw on abolition democracy as a conceptual framework in his post-Black Reconstruction work. Tracing the outlines of this framework in his unpublished manuscript A World Search for Democracy, I demonstrate how for Du Bois, the question of democracy remains fundamentally tied to the ongoing legacies of slavery. As he continues to draw on the Reconstruction era as an historical example, Du Bois gives further shape to the idea of abolition as a process in the present (rather than an event in the past). In doing so, he recuperates the unfulfilled promise of abolition democracy as a theoretical and practical model for considering alternatives modes of citizenship beyond the material, ideal, and embodied limits of liberal bourgeois democracy. Accordingly, I argue, in World Search, we can see the outlines of abolition democracy as a three-fold project: political-economic, epistemic, and affective. Each section of this article sheds light on one of these dimensions, drawing on theoretical models from Nancy Fraser, Sylvia Wynter, Sara Ahmed, and Dylan Rodríguez. By thus abstracting the concept of abolition democracy further from the historical movement analyzed in Black Reconstruction, I propose that Du Bois's World Search offers lessons that can inform abolitionist theory and praxis today.
Review of Poetic Operations: Trans of Color Art in Digital Media by micha cárdenas (Duke University Press)
Authors: Liang Shano (Hongyuan) , DeAnda Michael Anthony
Published: December 2022

'Poetic Operations' by micha cárdenas critically engages theory, activist, art, design, and lived experience to develop “trans of color poetics” to disrupt systems marking trans of color lives for death.
“Companionship and a Little Fun”: Investigating Working Women’s Leisure Aboard a Hudson River Steamboat, July 1919
Authors: Gallas Austin
Published: December 2022

This article provides an in-depth consideration of a single report penned on the night of July 27, 1919 by a private detective employed by New York City's Committee of Fourteen (1905–1932), an influential anti-vice and police reform organization. A close reading of the undercover sleuth's account, which details his experiences, subjective judgments, and general observations regarding moral and social conditions while aboard the Benjamin B. Odell, a palatial Hudson River steamboat, enables us to enrich our grasp of the courtship and pleasure-seeking practices popular among working women and men active in New York City's heterosocial and largely segregated amusement landscape during the so-called 'Red Summer.' Specifically, the report reveals how wage-earning women articulated femininity and sought individual freedoms, companionship, pleasure, and romance via Hudson River steamboat excursions. The relatively unsupervised atmosphere of such trips was appealing to some working women because it represented an affordable way to attain companionship, prohibited forms of amusement and entertainment, and sexual gratification, a way that sidestepped many of the reputational hazards typically associated with the search for such goods among mainland leisure spaces. Such opportunities were particularly valuable given the crackdowns on public sexuality and late-night amusement spaces that had followed America's entry into World War I in 1917 and the advent of 'wartime prohibition' on July 1, 1919. The article also supplies important contextual information required for proper appreciation of the investigation report in question, including a discussion of the methods and goals of the Committee of Fourteen and a brief overview of prior efforts by Progressive Era urban moral authorities to uncover and control 'white slavery,' gambling, and other 'vices' witnessed aboard steamboat excursions operating in and around New York, Chicago, and other coastal cities.
BOLSONARISMO COMO LINGUAGEM DA DESTRUIÇÃO: UMA CONVERSA SOBRE O MAL-ESTAR CIVILIZATÓRIO NO BRASIL RECENTE
Authors: Urzêda-Freitas Marco Túlio de , Vieira Letícia Lima
Published: December 2022

Neste texto, que percebemos como uma escrita-conversa, buscamos mobilizar algumas inquietações sobre o mal-estar que permeia o Brasil recente. Considerando que Jair Bolsonaro, atual Presidente da República, nunca se absteve de manifestar apreço por práticas autoritárias e violentas durante a sua carreira política, o que inclui a campanha eleitoral de 2018, o nosso principal objetivo foi esboçar uma compreensão da crise civilizatória revelada e potencializada por seu governo. Uma das perguntas que orientou o nosso diálogo foi: o que levou – e tem levado – milhares de brasileiros a legitimar esse projeto ancorado em uma linguagem da destruição? Ao destacarmos a condição de desamparo do sujeito e o potencial destrutivo da linguagem como questões cruciais para se compreender a performance do mal no Brasil contemporâneo, argumentamos em favor da afirmação do desamparo como força produtiva para uma (re)elaboração crítica da complexa e trágica realidade que vivemos.
Management of Stage 3 Haemorrhoids with Homoeopathy – A case report
Authors: Vijaykumar Jyothi , Bhat Dhanya Deepak
Published: December 2022

Haemorrhoids are abnormal masses of dilated blood vessels that can occur both internally and externally in the rectum. This is a case report of a 60-year-old woman who presented with complaints indicating Stage 3 haemorrhoids with a longstanding history of constipation. After acute case taking, observing the pathological progress of the disease and repertorising, Aesculus hippocastanum was prescribed. The patient’s condition and improvement were evaluated using the bleeding, prolapse, reduction, skin tags and thrombosis classification and staging at each follow-up. The patient showed marked improvement within a month. This case report emphasises the role of homoeopathic medicines in cases of haemorrhoids.
Dinamika dan Tipologi Pondok Pesantren di Cirebon
Authors: Fitri Meliani  , Andewi Suhartini  , Hasan Basri
Published: December 2022

Pesantren merupakan lembaga ritual keagamaan, pembinaan akhlak, pendidikan Islam, sekaligus lembaga sosial yang telah mengalami berbagai tantangan zaman yang disesuaikan dengan dinamika pertumbuhan masyarakat. Penelitian ini bertujuan untuk mendeskripsikan tentang tipologi dan dinamika Pesantren di Cirebon dari masa ke masa. Penelitian ini menggunakan pendekatan kualitatif. Sumber data primer dalam penelitian ini adalah buku Babad Cirebon Carub kandha naskah Tangkil, dan data sekunder didapatdari buku dan jurnal yang berkaitan dengan tipologi dan dinamika Pesantren di Cirebon. Berdasarkan penelitian pustaka yang dilakukan penyusun, didapatkan data tipologi pesantren yang terdapat di Cirebon terdiri dari pesantren salaf dan khalaf. Sebelum masa penjajahan, pesantren secara keseluruhan masih bertipe salaf, namun setelah ada akulturasi pendidikan formal berjenjang dari Belanda, maka mulai bermunculan pesantren khalaf, yang terdiri pendidikan sekolah dan luar sekolah. Pesantren modern baru bermunculan di Cirebon di awal abad 19. Contoh Pesantren Salaf di Cirebon adalah Pesantren Benda Kerep, dan contoh Pesantren Khalaf adalah Pesantren Buntet. Pesantren salaf di Cirebon hingga saat ini cenderung menutup diri pada modernisasi dan masih menggunakan sitem pembelajaran tradisional, tidak ada jenjang pendidikan formal, dan menghindari inovasi teknologi. Sedangkan pesantren khalaf di Cirebon sebaliknya, mendirikan sekolah berjenjang dan melakukan inovasi dalam pembelajaran. Baik pesantren salaf maupun khalaf adalah bagian sejarah dan budaya pendidikan Islam dengan kearifan lokal Indonesia dan perlu dilestarikan dan dikembangkan oleh masyarakat Indonesia.