bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining the Efficacy, Safety, and Future Prospects of Tirofiban in Managing Myocardial Infarction among Diabetic Patients
Authors: Samsudeen Haajeera , Shrinivasan V.P. Dharani
Published: February 2024

Background:

Myocardial infarction (MI) is a leading cause of death worldwide, particularly
in patients with diabetes mellitus (DM). Tirofiban, a platelet GP IIb/IIIa receptor inhibitor,
has shown promise as adjunctive therapy in the emergency management of MI in diabetic
patients. However, a comprehensive understanding of its use, efficacy, safety, and limitations in
this patient population is necessary to optimize treatment strategies and improve patient outcomes.

Methodology:

This review article utilized a systematic approach to gather relevant research articles,
clinical trials, and studies on the use of tirofiban in the therapy of MI in diabetic patients.
Databases, such as PubMed and Google Scholar, were extensively searched using specific keywords
related to tirofiban, MI, DM, STEMI, and antiplatelet therapy. The collected data were
carefully examined, summarized, and analyzed to provide an extensive overview of using tirofiban
in the management of MI in diabetic individuals.

Results:

The analysis of the gathered literature revealed that tirofiban has demonstrated efficacy
in improving clinical outcomes, reducing myocardial ischemia-reperfusion injury, and promoting
early recovery of heart function in diabetic patients with MI undergoing percutaneous coronary
intervention. The fast on- and off-rate and dose-dependent effect of the drug on platelet aggregation
contribute to its effectiveness. However, caution should be exercised due to the potential
risk of tirofiban-associated thrombocytopenia. Clinical trials and studies have provided evidence-
based dosing guidelines, enabling the safe and effective administration of tirofiban in this
patient population.

Conclusion:

Tirofiban, a platelet GP IIb/IIIa receptor inhibitor, shows promise as adjunctive
therapy in the emergency management of MI in diabetic patients. It has demonstrated efficacy in
improving clinical outcomes, reducing myocardial ischemia-reperfusion injury, and promoting
early recovery of heart function. However, healthcare providers should be cautious regarding the
potential risk of tirofiban-associated thrombocytopenia. Further research is needed to optimize
dosing guidelines, evaluate long-term safety, and fully understand the benefits and limitations of
tirofiban in this patient population. The comprehensive insights provided in this review aim to
enhance treatment strategies and improve patient outcomes in the emergency management of MI
in diabetic individuals.
Glp-1 Mimetics and Autophagy in Diabetic Milieu: State-of-the-Art
Authors: Yaribeygi Habib , Maleki Mina , Santos Raul D. , Jamialahmadi Tannaz , Sahebkar Amirhossein
Published: February 2024

The diabetic milieu is associated with cascades of pathophysiological pathways that
culminate in diabetic complications and tissue injuries. Autophagy is an essential process mandatory
for cell survival and tissue homeostasis by degrading damaged organelles and removing injured
cells. However, it may turn into a pathological process in an aberrant mode in the diabetic
and/or malignant milieu. Moreover, autophagy could serve as a promising therapeutic target for
many complications related to tissue injury. Glp-1 mimetics are a class of newer antidiabetic
agents that reduce blood glucose through several pathways. However, some evidence suggests
that they can provide extra glycemic benefits by modulating autophagy, although there is no
complete understanding of this mechanism and its underlying molecular pathways. Hence, in the
current review, we aimed to provide new insights on the possible impact of Glp-1 mimetics on
autophagy and consequent benefits as well as mediating pathways.
Structure-Activity Relationship Studies on VEGFR2 Tyrosine Kinase
Inhibitors for Identification of Potential Natural Anticancer Compounds
Authors: Verma Meenakshi , Sarfraz Aqib , Hasan Inamul , Vasudev Prema Gauri , Khan Feroz
Published: February 2024

Background:

Over-expression of Vascular Endothelial Growth Factor Receptors (VEGFRs)
leads to the hyperactivation of oncogenes. For inhibition of this hyperactivation, the USA
Food Drug Administration (FDA) has approved many drugs that show adverse effects, such as
hypertension, hypothyroidism, etc. There is a need to discover potent natural compounds that show
minimal side effects. In the present study, we have taken structurally diverse known VEGFR2 inhibitors
to develop a Quantitative Structure-Activity Relationship (QSAR) model and used this
model to predict the inhibitory activity of natural compounds for VEGFR2.

Methods:

The QSAR model was developed through the forward stepwise multiple linear regression
(MLR) method. A developed QSAR model was used to predict the inhibitory activity of natural
compounds. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessment
and molecular docking studies were performed. The binding stability of the natural compounds
with VEGFR2 was elucidated through molecular dynamics (MD) simulation.

Results:

The developed QSAR model against VEGFR2 showed the regression coefficient of the
training dataset (r2) as 0.81 and the external regression coefficient of the test dataset (r2
test) 0.71.
Descriptors, viz., electro-topological state of potential hydrogen bonds (maxHBint2, nHBint6),
atom types (minssNH), maximum topological distance matrix (SpMAD_Dt), and 2D autocorrelation
(ATSC7v), have been identified. Using this model, 14 natural compounds have been selected
that have shown inhibitory activity for VEGFR2, of which six natural compounds have been found
to possess a strong binding affinity with VEGFR2. In MD simulation, four complexes have shown
binding stability up to 50ns.

Conclusion:

The developed QSAR model has identified 5 conserved activity-inducing physiochemical
properties, which have been found to be correlated with the anticancer activity of the nonidentical
ligand molecules bound with the VEGFR2 kinase. Lavendustin_A, 3’-O-acetylhamaudol,
and arctigenin have been obtained as possible lead natural compounds against the VEGFR2 kinase.
Quantification of Rutin, an Anti-glycating Drug, in Selected Euphorbia
Species by Florescence Spectroscopy and Partial Least Squares Regression
Analysis
Authors: Ali Maroof , Khan Ajmal , Gilani Syed Abdullah , Ali Liaqat , Maqsood Rabia , Hussain Amjad , Al Rabani Hamida , Rehman Najeeb Ur , Jabeen Farah , Mabood Fazal , Al-Harrasi Ahmed , Hussain Javid
Published: February 2024

Background:

Rutin is a natural flavonol that showed excellent antiglycation activity with
an IC50 value of 294.5 ± 1.5 μM. In the current study, three selected plant species of Euphorbia, i.e.,
Euphorbia helioscopia, Euphorbia larica, and Euphorbia wallichii, were analyzed for the quantification
of rutin.

Methods:

The quantification was done through a newly developed method of Emission spectroscopy
coupled with Partial Least Square Regression (PLSR) and UV-visible spectroscopy as a parallel
cross-validation method.

Results:

The spectroscopic results indicated the highest rutin concentration in the roots of E. helioscopia
(11.25 mg/100 g) followed by roots of E. wallichii (9.93 mg/100 g), leaves of E. helioscopia
and the whole plant of E. larica (9.41 mg/100 g). The leaves of E. wallichii (8.66 mg/100 g) were
found to contain the lowest concentration of rutin among all the tested samples.

Conclusion:

The present method is one of the simple, robust, and non-destructive methods to carry
out the quantitative estimation of rutin in plants.
Effect of Syzygium cumini on Oxidative Stress Induced Cardiac Cellular Anomalies
Authors: Bhadana Renu , Rani Vibha
Published: February 2024

Introduction:

Doxorubicin (Dox), an antineoplastic agent is used as a primary anticancerous
drug against various types of cancers. However, its associated toxicity to the cardiovascular
system is major. Literature has recorded the cases of mortality due to poor validation
and lack of prediagnosis of Dox-induced cardiotoxicity. Therapeutic interventions using natural
products having cardioprotective properties with low toxic outcomes hold therapeutic potential for
future cardio-oncological therapies. Syzygium cumini (Black berry), a traditional Indian herbal
plant, has been researched and found to exert cardioprotective, anti-inflammatory, and antioxidant
activities, which have been credited due to the presence of polyphenols, flavonoids, and tannins.

Methods:

In the current research, we investigated the cardioprotective potential of Syzygium
cumini against Doxorubicin-induced cardiotoxicity (DIC) in H9C2 cardiomyocytes. Methanolic
seed extract preparation of Syzygium cumini was performed using the Soxhlet apparatus. Cell
viability and cell death assays were performed to determine the cardiotoxic doses of Doxorubicin.
Furthermore, the cardioprotective potential of Syzygium cumini extract against DIC was
studied. Morphological and nuclear alterations in H9C2 cells were studied by microscopic assays
using Giemsa, Haematoxylin-Eosin stain, and PI. The intracellular stress level and ROS production
were studied using DCFH-DA followed by mitochondrial integrity analysis using fluorescent
microscopic methods.

Results:

In the results, we investigated that Dox exerted a dose and time-dependent cardiotoxicity
on H9C2 cardiomyocytes. Moreover, we observed that morphological and nuclear alterations
caused by doxorubicin in dose-dependent manner were prevented by supplementing with Syzygium
cumini polyphenols and it attenuated the oxidative stress in H9C2 cardiomyocytes effectively.

Conclusion:

Conclusively, Syzygium cumini possesses cardioprotective potential in H9C2 cardiomyocytes
in dox-induced cardiotoxicity.
Actinomyces-induced Osteomyelitis of the Mandible - A Rare Disease?
Authors: Nieves-Velez Caleb , Rivera-Gonzalez Gilberto , Antony Suresh
Published: February 2024

Background:

Actinomyces species are commensal oral cavity flora that can cause jaw
osteomyelitis. Osteomyelitis of the jaw by Actinomyces is rare, and its presentation can be confused with many different pathologies.

Case presentation:

This is the case of a 61-year-old female with breast cancer and on chemotherapy as well as non-invasive carcinoma of the tongue who initially presented to the dentist with
white spots in the right mandible near the incisors associated with right mandible pain and swelling. Actinomyces-induced osteomyelitis of the mandible was diagnosed. The patient was treated
with penicillin V for 6 weeks along with a course of hyperbaric oxygen therapy, which resulted
in the complete resolution of the infection.

Conclusion:

In summary, jaw osteomyelitis caused by Actinomyces should always be part of the
differential diagnosis; as these organisms are commensal flora, the symptoms manifested are nonspecific, and such a diagnosis could be easily missed, resulting in delay of care and disease progression.
Construction of Camelus dromedaries Immune Single Domain Antibodies Library for Development of Schistosoma mansoni Specific Nanobodies Using Phage Display Strategy
Authors: El-Kalamawy Hadeer Adel , Awwad Mohammed H. , Diab Tarek M. , Okasha Hend , Abdel-Kareim Amal M. , Marawan Marawan A. , Shoulah Salma A. , El-Dabaa Ehab
Published: February 2024

Background:

Schistosoma mansoni poses a considerable global public health challenge.
In Egypt, approximately 60% of the inhabitants in the Northern and Eastern areas of the
Nile Delta are affected by this parasite, whereas the Southern region experiences a significantly
lower infection rate of 6%.

Aim:

Construction of an immune phage display Nbs library based on the VHH framework for
selecting S. mansoni-specific Nbs for seeking cost-effective, sensitive, and specific diagnostic
tools for rapidly detecting Schistosoma mansoni.

Methods:

Camel was immunized using soluble adult worm antigens (SAWP) for the production
of Variable domains of heavy chains of camelid heavy-chain only antibodies (VHHs),
which are known as nanobodies (Nb). The PBMCs repertoires VHH sequences library have
been constructed with a high percentage of insertion and right orientation using pADL-23c
phagmid and M13 phage followed by three rounds of bio-panning against SAWP using phage
display technique. Evaluations using polyclonal phage ELISA and other techniques have been
carried out to reveal the successful enrichment of anti-SAWP Nbs (VHH) clones. Evaluation
of the diagnostic potentiality of these Nbs was carried out using ELISA on human serum samples
confirmed for S. mansoni infection. Receiver Operator of Characteristics (ROC) curve
analysis was used for discrimination between S. mansoni infection and both negative controls
and the Fasciola hepatica group.

Results:

Using monoclonal ELISA, Nbs of 22 clones out of 24 selected clones showed binding
affinity to SAWP. The cutoff values of the produced anti-S. mansoni Nbs was > 0.19, leading to
80% sensitivity, 95% specificity, and 90% accuracy. Sequence analysis of three of these Nbs with
high binding affinities showed diversity in their targets, considering their CDR3 aa sequences.

Conclusion:

This study successfully generated a diverse phage library enriched with anti-S.
mansoni VHHs. The nanobodies produced exhibit high diagnostic potential for detecting S.
mansoni infection in human patients, offering a promising avenue for the development of efficient
diagnostic tools. The innovative approach described herein may have potential applications
for patent considerations in the field of the field of diagnostic technology.
Cross-attention Based Text-image Transformer for Visual Question
Answering
Authors: Rezapour Mahdi
Published: February 2024

Background:

Visual question answering (VQA) is a challenging task that requires
multimodal reasoning and knowledge. The objective of VQA is to answer natural language
questions based on corresponding present information in a given image. The challenge of VQA
is to extract visual and textual features and pass them into a common space. However, the
method faces the challenge of object detection being present in an image and finding the relationship between objects.

Methods:

In this study, we explored different methods of feature fusion for VQA, using pretrained models to encode the text and image features and then applying different attention
mechanisms to fuse them. We evaluated our methods on the DAQUAR dataset.

Results:

We used three metrics to measure the performance of our methods: WUPS, Acc, and
F1. We found that concatenating raw text and image features performs slightly better than selfattention for VQA. We also found that using text as query and image as key and value performs worse than other methods of cross-attention or self-attention for VQA because it might
not capture the bidirectional interactions between the text and image modalities

Conclusion:

In this paper, we presented a comparative study of different feature fusion methods for VQA, using pre-trained models to encode the text and image features and then applying
different attention mechanisms to fuse them. We showed that concatenating raw text and image
features is a simple but effective method for VQA while using text as query and image as key
and value is a suboptimal method for VQA. We also discussed the limitations and future directions of our work.
Terre promise, pays perdu? Approches de Désorientale de Négar Djavadi
Authors: Outeirinho Fátima
Published: February 2024

Of Iranian origin, screenwriter and director, Négar Djavadi published, in 2016, Désorientale, her first novel, distinguished, the same year, by the Prix de L’Autre Monde and the Prix du Style, and, in 2017 by the Prix Emmanuel Roblès, the Prix Première, the Prix Littéraire de la Porte Dorée and the Novel News Prize. By means of a first-person narrative, this promising entry into literature erects a whole universe that interweaves various histories and temporalities: on the one hand, the history of Iran in the 20th century, the history of the Iranian family ‘s exile – the Sadr – and, on the other hand, the daily experience and over time, of Kimiâ Sadr, the narrator, prey to her (re)construction of identity, already announced in the title of the work. Our approach to the novel Désorientale will focus on the issues that emerge from displacement, exile or wandering, and from liminalities to be resolved that are beyond a national inscription.
Désir de l’assimilation identitaire dans la littérature beure
Authors: Belarbi Mokhtar
Published: February 2024

The texts written by so-called “Beur” authors reflect the denial carried by them against their fellow citizens. Unlike the majority of critics who are interested in the “beur” question, we believe that their literary production, which is essentially structured around the identity divide, shows their refusal to be associated with the ancestral culture that they consider it to be dilapidated and outdated. They want recognition of their true identity which is that of the country of birth. Through their texts, they express the desire for identity assimilation.
INTEGRATION OF TAGUCHI AND PROMETHEE FOR CNC MILLING MACHINING PARAMETER OPTIMIZATION ON AA6061
Authors: Ihsan Muhammad Alif , Sumantri Yeni , Irawan Yudy Surya
Published: February 2024

In the manufacturing industry, machining has developed quite rapidly from the use of conventional machines to unconventional machines. Unconventional machines that are often used today are optimize computer numerically controlled (CNC), the use of CNC in the manufacturing industry provides many benefits in product quality and productivity. One of them is CNC milling, this type is one of the main machines on the production floor. Machining optimization becomes the main goal to achieve the ideal response in order to produce products with good and consistent quality and productivity. Surface quality leads to surface roughness, while productivity leads to material removal rate. This study aims to optimize CNC milling machining parameters on AA6061 with Taguchi experimental design and preference ranking organization method for enrichment evaluation (PROMETHEE) method. Machining was controlled using wet machining conditions to maintain temperature during machining. Experiments were conducted nine times with three factors and levels. These factors included spindle speed, feed rate, and depth of cut.  The result of this research is the ideal value of the combination of surface roughness and material burning rate which is 0.565 (experiment 3). This best experiment is influenced by spindle speed 2600 rpm, feed rate 65 mm/min, and depth of cut 2.5 mm. Feed rate has the largest contribution in influencing the response which is 43.23%, followed by depth of cut 25.24%, and spindle speed 15.91%.
OPTIMAL SETTINGS OF A MELON SEED SHELLER USING STATISTICAL DESIGN OF EXPERIMENTS
Authors: Tchoupou Tsapi  Kevin , Bisong Samuel Mbelle , Fotsing Bertin Soh
Published: February 2024

A community melon seed shelling machine, used by farmers and households to reduce the constraints associated with the manual processing, was found to produce larger quantities of unshelled seeds. In particular, the optimum seed moisture content and motor speed were unknown.  The objective of this study was to determine the appropriate motor speed and moisture content of melon seeds to improve the effectiveness of seed dehulling. A full factorial design approach was used to develop a regression model and investigate the effect of moisture content and machine speed on dehulling efficiency. The results of the experiments showed that both motor speed and seed moisture content had a significant effect on seed shelling efficiency. The motor speed had the greatest effect (0.21567), followed by the moisture content (0.19732).  The modelled optimization conditions were as follows: seed moisture content at 26%, motor speed at 2100 rpm. The regression model showed a coefficient of determination value of 0.999, indicating that 99.90% of the variation in response could be explained by the model; only 0.1% of the variation in response could not be explained by the model and was random. Three experimental validation runs were carried out under optimal conditions, and the highest average yield was 86.2%, corresponding to a significant improvement of 26% on the initial yield of 60 %.  Other experimental design methods should be investigated to improve the results for appropriate parameter settings of the production process.
RPM MEASUREMENT COMPARISON USING A THERMOMETER AND LM393 MICROCONTROLLER
Authors: Nanda Rizki Aulia , Karyadi Karyadi , Roban Roban , Dewadi Fathan Mubina
Published: February 2024

RPM measurement is a crucial measurement tool for assessing a machine's rotation quality and ensuring that it meets the DC motor manufacturer's specifications. The quality of rotation of electric motors and combustion motors can both be observed through RPM measurements. The precision with which the LM393 sensor measures the rotation of a DC motor engine is the problem formulation in this study. Thus, the purpose of this study is to evaluate the rotation measurement accuracy of the LM393 Microcontroller sensor and compare it to a traditional tachometer. In order to conduct rotational variations on the DC motor, the following voltages will be applied: 0.93V, 2.83V, 4.25V, 7.05V, and 9.07V. Next, a tachometer and an LM393 microcontroller are used to measure the DC motor rotation. The gathered data will be made available for verification. Based on the measurement results, the corresponding data differences are -5.560 RPM, -1.577 RPM, -2.182 RPM, -3 RPM, and 0.334 RPM. Therefore, measurement validation was done based on the disparity in readings, yielding results of 0.252%, -1.45%, 0.12%, 0.038%, and 0.0725%. Based on validation results showing a presentation of no more than 10%, the LM393 measuring tool for DC motor RPM measurement is deemed valid and suitable for use.
PYROLYSIS OF CORN COB BIOMASS TOWARD GASEOUS PRODUCTS ON SMALL CAPACITY REACTOR
Authors: Yuliansyah Fisal , Hamidi Nurkholis , Sasongko Mega Nur
Published: February 2024

Corn waste is the result of agricultural production that can be further utilized and get additional economic for the community. Waste Corn cab is one of Indonesia abundant biomass apart from. The utilization of biomass by implementing pyrolysis process can be viable solution. This study aims to observe the determination corn cab pyrolysis using HCL-bentonite activation and without bentonite towards syngas product (CH4-H2-CO-CO2). Updraft reactor was utilized for 30 minutes pyrolysis process. We used MQ4, MQ8, MQ7 coupled with Arduino UNO for measuring CH4, H2, CO2 and CO in ppm unit. Compared without bentonite, the result showed that methane (CH4) gas production increased. In addition, we found also that hydrogen (H2) gas increased respectively. Not mention, the content of CO increased.
Strengthening the Biosecurity System After the Spread of Foot and Mouth Disease (Pmk) on Beef Cattle Farms at the Al Fatih Islamic Boarding School, Pamekasan Regency
Authors:   Jurusan Biologi, Fakultas MIPA, Universitas Brawijaya, Djati M. Sasmito
Published: February 2024

Kegiatan pengabdian masyarakat ini dilakukan di Pesantren Al Fatih di Desa Klampar Kecamatan Proppo, Kabupaten Pamekasan Madura. Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk meningkatkan kualitas pengelolaan usaha peternakan sapi pedaging, dan untuk meningkatkan peran dan fungsi pondok pesantren sebagai pendidikan non formal guna mendukung ketahanan pangan serta penguatan penerapan biosecurity dalam upaya pencegahan PMK. Metode yang digunakan dalam kegiatan ini melalui observasi lokasi, diskusi dan wawancara, Participatory Rural, Participatory Technology Development, Educative, Forum Group Discussion (FGD). Hasil kegiatan menunjukkan bahwa peserta sangat antusias saat pelaksanaan. Edukasi yang diberikan pada peserta memberikan peningkatan pengetahuan tentang biosecurity yang signifikan, dari nilai pre-test 68.86 point, sedangkan nilai post-test 78.16 point, sehingga terjadi peningkatan 14%. Pengetahuan yang diaedukasikan meliputi; biosecurity PMK, sanitasi kandang, biosecurity keluar masuk wilayah farm/peternakan dan isolasi sapi yang sakit. Kesimpulan dalam kaegiatan ini adalah, peserta mampu memahami tentang materi peningkatan kualitas ternak melalui biosafety dan biosecurity PMK dan menerapkan teknologi tepat guna tentang formulasi pakan, dan sanitasi kandang untuk pencegahan dan reinfeksi PMK.
LESSONS LEARNED: HOW FENTANYL IS IMPACTING ORGANIZED CRIME IN NORTH AMERICA
Authors: Dittmar Victoria
Published: February 2024

On November 15, 2023, Victoria Dittmar presented Lessons Learned: How Fentanyl is Impacting Organized Crime in North America for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were how fentanyl is changing how law enforcement agencies in North America deal with drug trafficking, that fentanyl is a minuscule market and overlaps with legal markets, and that the drug has become democratized with cartels playing only a limited role. 

 

Received: 01-14-2024

Revised: 01-26-2024
2023 WEST COAST SECURITY CONFERENCE WELCOMING REMARKS DAY 4
Authors: Serviss Samuel
Published: February 2024

On November 16, 2023, Captain Samuel Serviss presented the opening remarks for the fourth day of this year’s West Coast Security Conference. The key points discussed were the contrast between the optimism following the end of the Cold War regarding lasting global peace and the current reality of intra- and inter-state conflicts, as well as the role of events such as the West Coast Security Conference as opportunities for critical reflection and understanding of war as a means of working towards peace. 

 

Received: 01-14-2024

Revised: 01-26-2024
Editoras como instrumentos de aferição do posicionamento internacional da literatura infantojuvenil portuguesa
Authors: Costa Inês
Published: February 2024

O presente artigo tem como objetivo averiguar o posicionamento internacional da literatura infantojuvenil portuguesa contemporânea, a partir da caracterização das editoras que, nas últimas duas décadas, adquiriram direitos de tradução e publicaram obras portuguesas em outros países. A partir de um estudo de caso, centrado no catálogo da prestigiada editora Planeta Tangerina, far-se-á uma análise empírica sustentada em dados recolhidos acerca da dimensão das editoras estrangeiras, da sua associação a circuitos de produção de larga ou pequena escala (Bourdieu 1993, 2008), dos objetivos e missão que comunicam oficialmente e da composição do seu catálogo. Atendendo às especificidades deste subsistema literário, averiguar o posicionamento da literatura infantojuvenil portuguesa nos diversos mercados nacionais e numa perspetiva global implica também compreender a forma como esta é percecionada face à ponderação das três vertentes que a enformam: a vertente estética, a vertente didática e a vertente lúdica.
Apresentação
Authors: Guerini Andréia , Ferreira Alves Fernando , Grossegesse Orlando
Published: February 2024

O presente volume da Diacrítica faz parte de uma publicação conjunta, realizada em parceria com Cadernos da Tradução (PGET, UFSC, Florianópolis), que pretende dar a conhecer os artigos elaborados a partir de comunicações apresentadas durante o X Congresso Internacional da Associação Ibérica de Estudos de Tradução e Interpretação (AIETI). Sob o título “Circum-navegações transtextuais e culturais”, parcialmente inspirado em The Poetics of Translation de Willis Barnstone, este congresso decorreu nos dias 15, 16 e 17 de junho de 2022, no Campus de Gualtar da Universidade do Minho (Braga), através da sua Escola de Letras, Artes e Ciências Humanas (ELACH) e do seu Centro de Estudos Humanísticos (CEHUM).
Multicriteria Decision-Making in Diabetes Management and Decision Support: Systematic Review
Authors: Aldaghi Tahmineh , Muzik Jan
Published: February 2024

Background

Diabetes mellitus prevalence is increasing among adults and children around the world. Diabetes care is complex; examining the diet, type of medication, diabetes recognition, and willingness to use self-management tools are just a few of the challenges faced by diabetes clinicians who should make decisions about them. Making the appropriate decisions will reduce the cost of treatment, decrease the mortality rate of diabetes, and improve the life quality of patients with diabetes. Effective decision-making is within the realm of multicriteria decision-making (MCDM) techniques.

Objective

The central objective of this study is to evaluate the effectiveness and applicability of MCDM methods and then introduce a novel categorization framework for their use in this field.

Methods

The literature search was focused on publications from 2003 to 2023. Finally, by applying the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method, 63 articles were selected and examined.

Results

The findings reveal that the use of MCDM methods in diabetes research can be categorized into 6 distinct groups: the selection of diabetes medications (19 publications), diabetes diagnosis (12 publications), meal recommendations (8 publications), diabetes management (14 publications), diabetes complication (7 publications), and estimation of diabetes prevalence (3 publications).

Conclusions

Our review showed a significant portion of the MCDM literature on diabetes. The research highlights the benefits of using MCDM techniques, which are practical and effective for a variety of diabetes challenges.
Effectiveness of Chinese Herbal Medicine as a Complementary Treatment for Neutropenia Prevention and Immunity Modulation During Chemotherapy in Patients With Breast Cancer: Protocol for a Real-World Pragmatic Clinical Trial
Authors: Wang Kai-Hung , Shen Hsuan-Shu , Chu Sung-Chao , Wang Tso-Fu , Lin Ching-Wei , Huang Wei-Han , Wu Yi-Feng , Ho Ching-Chun , Pang Cheng-Yoong , Li Chi-Cheng
Published: February 2024

Background

In recent years, advancements in cancer treatment have enabled cancer cell inhibition, leading to improved patient outcomes. However, the side effects of chemotherapy, especially leukopenia, impact patients’ ability to tolerate their treatments and affect their quality of life. Traditional Chinese medicine is thought to provide complementary cancer treatment to improve the quality of life and prolong survival time among patients with cancer.

Objective

This study aims to evaluate the effectiveness of Chinese herbal medicine (CHM) as a complementary treatment for neutropenia prevention and immunity modulation during chemotherapy in patients with breast cancer.

Methods

We will conduct a real-world pragmatic clinical trial to evaluate the effectiveness of CHM as a supplementary therapy to prevent neutropenia in patients with breast cancer undergoing chemotherapy. Patients will be classified into CHM or non-CHM groups based on whether they received CHM during chemotherapy. Using generalized estimating equations or repeated measures ANOVA, we will assess differences in white blood cell counts, absolute neutrophil counts, immune cells, and programmed cell death protein 1 (PD-1) expression levels between the 2 groups.

Results

This study was approved by the research ethics committee of Hualien Tzu Chi Hospital (IRB 110-168-A). The enrollment process began in September 2021 and will stop in December 2024. A total of 140 patients will be recruited. Data cleaning and analysis are expected to finish in the middle of 2025.

Conclusions

Traditional Chinese medicine is the most commonly used complementary medicine, and it has been reported to significantly alleviate chemotherapy-related side effects. This study’s findings may contribute to developing effective interventions targeting chemotherapy-related neutropenia among patients with breast cancer in clinical practice.

Trial Registration

International Traditional Medicine Clinical Trial Registry ITMCTR2023000054; https://tinyurl.com/yc353hes

International Registered Report Identifier (IRRID)

DERR1-10.2196/55662
Optical and Crystal Structure Properties of ZnO Nanoparticle Synthesized through Biosynthesis Method for Photocatalysis Application
Authors: Suciyati Sri Wahyu , Manurung Posman , Junaidi Junaidi , Situmeang Rudy
Published: February 2024

In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized from zinc nitrate hexahydrate precursor and mango leaf extract (MLE). The purpose of this research was to investigate the crystal structure and optical properties exhibited by ZnO NPs for photocatalytic applications. ZnO NPs produced from various concentrations of sodium hydroxide (NaOH) and the addition of MLE during the synthesis stage demonstrated intriguing physical structure and optical properties. XRD characterization results revealed the attainment of a pure ZnO phase with a high crystallinity degree in all samples. Biosynthesis with MLE unveiled minor peaks corresponding to the cellulose phase. The achieved crystallite size ranged from 15–28 nm. The FTIR patterns detected in the wavenumber range of 600–4000 cm−1 indicated successful crystallization of all ZnO NPs samples. The band gap energy for each sample (ZnO-A to ZnO-E) is indicated to be in the range of 3.25, 3.25, 3.26, 3.31, and 3.17 eV, as demonstrated by the Tauc relation. The effect of MB degradation by the ZnO-E photocatalyst is revealed by the photodegradation of 96.46%.
Hexahydro-1,2,3-triazine Derivatives: Synthesis, Antimicrobial Evaluation, Antibiofilm Activity and Study of Molecular Docking Against Glucosamine-6-Phosphate
Authors: Ayrim Nabel Bunyan , Hafedh Fadhel Rukhis , Kadhim Yasir Mohamed , Hussein Abduljabbar Sabah , Abdula Ahmed Mutanabbi , Mohsen Ghosoun Lafta , Sami Mohammed Mahdi
Published: February 2024

The N,N',N''-trisubstituted hexahydro-1,3,5-triazine derivatives (3a–g) had been created and identified through infrared, nuclear magnetic resonance, and mass spectrometry according to their symmetric basic structure. Three molecules of diverse aromatic amines and three molecules of formaldehyde were assembled in a "1+1+1+1+1+1" condensation reaction to produce hexahydrotriazines. Two Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis) and two Gram-negative (Klebsiella pneumonia, Pseudomonas aeruginosa) bacteria were used to evaluate the antimicrobial activity of the produced compounds. The anti-biofilm activity of 3g against S. aureus was also examined. In this investigation, glucosamine-6-phosphate synthase was employed to investigate the binding affinity of 3g within the enzyme's binding site. The results demonstrated that most of the synthesized hexahydro-1,3,5-triazine compounds have mild antimicrobial effects in comparison with the commonly used drug ampicillin, whereas the compounds 3g are potentially anti-biofilm agents. Molecular docking with the Autodock 4.2 tool was applied to study the binding affinity. It was found to hit (3g) in the active center of glucosamine-6-phosphate synthase as the target enzyme for antimicrobial agents. In silico studies reveal that the discovered hit is a promising glucosamine-6-phosphate inhibitor, as well as that the docking data matched up to the in vitro assay.
Recent Advancement and Emerging Applications of Lignin
Authors: Mittal Tanu , Kant Rishi , Bhalla Yogesh , Goel Mohit Kumar
Published: February 2024

Lignin is a significant renewable natural energy resource these days, used as an environmentally acceptable and sustainable alternative fossil fuel feedstock in a huge possibility of value-added products. Lignin is a polymeric molecule that possesses an aromatic unit structure, together with cellulose, and is a main component of the cell walls of plants. It is the byproduct of agriculture residues and biorefinery products and can be extracted from paper-pulp industries. Properties of lignin may differ depending on the extraction method and source and also on an aromatic ring as the main constituent of lignin in the structure. This rare composition of lignin makes it more valuable, allowing for value-added applications such as in the field of storage devices and energy harvesters. This review focuses on derivatives of lignin, structure and composition sources and characteristics, and its sustainable emerging application in various fields are discussed.
Do Natural Disasters Induce More Crime?
Authors:   Binghamton University, Lentini Michael , Nikolov Plamen , Schwartz Matthew
Published: February 2024

The Indian Ocean Tsunami of 2004 resulted in grave consequences for South East Asia. Indonesia, in particular, had the highest death toll, losing over 150,000 people. Indonesia’s coastal region Aceh was the hardest hit by this disaster. Exploiting exogenous spatial variation at the district level, we use difference-in-difference analysis to estimate the causal effect of the 2004 disaster on subsequent crime rates. We find that after the tsunami, total annual crime rate went down, on average, by 244 crimes per annum.
Bacteriófagos y producción de alimentos
Authors: Moreno Figueroa Luis Daniel , Hernández Adame Luis , Quiroz Guzmán Eduardo
Published: February 2024

La acuicultura enfrenta grandes retos y problemáticas, entre los que destacan la activación frecuente de enfermedades de tipo bacteriana. En ese contexto, la aparición de cepas patógenas ha causado graves pérdidas económicas debido su alta mortalidad. Una estrategia innovadora de biocontrol es el uso de bacteriófagos líticos, los cuales eliminan a las bacterias como parte de su ciclo de replicación y evitan la proliferación de éstas de manera inocua para con el organismo y el medio circundante. Recientemente se ha demostrado que el uso de biopolímeros como agentes preservadores de los fagos es una manera eficaz para incrementar su viabilidad, mejorar su estabilidad e incrementar el tiempo de residencia dentro del sistema digestivo de los organismos cultivados. En este sentido, este trabajo pretende explicar de manera clara y sencilla el papel de los fagos líticos en la producción de pescados y mariscos, así como su preservación, para usarlos como tratamiento en el control de bacterias patógenas.
Las interacciones entre derecho y filosofía en el caso Damián Ximenez Lopes x Brasil en la Corte Interamericana de Derechos Humanos-CIDH / OEA
Authors: Lamera Cabral Rafael
Published: February 2024

La filosofía política y moral pasa a ser debatida con mayor profundidad en los análisis del Derecho Constitucional después de la Segunda Guerra Mundial y, por lo tanto, es necesario revisar las formas jurídicas hasta entonces consagradas por los cánones del Derecho. Si este elemento de la filosofía constitucional contemporánea es evidente en el constitucionalismo brasileño, las decisiones jurídicas que aquí se producen, así como las vinculadas a los derechos humanos en el ámbito internacional, no siempre son elucubraciones directas del mismo paradigma. Para que sea posible la identificación de esta observación, el objetivo de este trabajo es analizar la decisión judicial en el Caso Damián Ximenes Lopes contra Brasil, proferida por la Corte Interamericana de Derechos Humanos de la OEA.
The relationship between childhood maltreatment and its effects on self esteem among youth
Authors: Razak Nurul Nabilah Abdul , Perveen Asma
Published: February 2024

This present study aimed to investigate the relationship between childhood maltreatment and its effect on self-esteem among youth. This study was conducted through the survey method, using an online survey via Google Form for the respondents. The total number of respondents received is 156 (n =156) participants from youth aged 18 to 30, with 74 (47.4%) male respondents and 82 (52.6%) female respondents who are willing to participate in the study. Instruments used in this study were the Childhood Trauma Questionnaire (CTQ) and the Rosenberg Self-Esteem Scale (RSES). This research includes the use of descriptive analysis for the demographic information. Meanwhile, the research hypothesis was tested using Pearson’s correlation to obtain the results between the two variables. Results indicated that emotional neglect has the highest number of childhood maltreatment experiences by youth, but emotional abuse has the most severe case. Childhood maltreatment had a strong negative correlation with self-esteem (r(156) = 0.671, p <0.001). Among the respondents, the increase in the level of childhood maltreatment was correlated with a decrease in self-esteem. Through this study, screening children’s conditions and environment early with extensive intervention is essential to preventing such adverse complications.
The role of personality on resilience-moderated work stress in employees
Authors: Hasudungan Gerald Nicholas , Mustika Martina Dwi
Published: February 2024

The COVID-19 pandemic has had an impact on the entire business industry. Various companies are facing the post-pandemic situation and are trying to make adjustments to the current situation. The adjustments made by these companies create an impact on employees and lead to work stress for them. This study aims to examine the moderating effect of resilience on the relationship between personality and employee work stress. The results of previous research found inconsistencies in the results of the correlation between personality and employee work stress. Resilience, which can buffer the effects of work stress, is used as a moderating variable. The number of respondents who were actively involved was 499, who were employees aged 22–40 years and worked in various business sectors. All respondents have filled out three measurement scales: the personality scale, the work stress scale, and the resilience scale. Data collection was carried out using Google Forms. This study conducted a moderation analysis using the Hayes model 1 macro process to test the research model. Study findings show that the role of resilience moderates the relationship between personality and employee work stress (p = 0.003). The findings also show that resilience will be able to reduce work stress felt by individuals. Resilience is a component that can protect individuals from the impact of work stress. Companies need to provide assistance to improve their employees' resilience skills to reduce the daily effects of work stress.
Experiência de criação e implementação do programa “adolescer com saúde” no contexto escolar
Authors: Ribeiro Barbara Santos , Boery Rita Narriman Silva de Oliveira , Duarte Ana Cristina Santos , Vilela Alba Benemérita Alves , Soares Carine de Jesus , Teixeira Jules Ramon Brito
Published: February 2024

Objetivo: Relatar a experiência de criação e implementação de um programa para promoção da saúde mental de adolescentes escolares. Materiais e métodos: Relato de experiência obtido a partir da imersão no contexto escolar, no período de 2019 a 2021, para realização de inquérito epidemiológico seguido da elaboração de um programa para capacitação de familiares de adolescentes e trabalhadores escolares sobre saúde mental de adolescentes. A pesquisa ocorreu em escolas públicas de um município baiano. Todas as experiências obtidas a partir de observação participante foram registradas em um diário de campo. Resultados: O sofrimento psíquico percebido entre adolescentes tem sido uma questão preocupante, pois afeta a qualidade de vida desse grupo. Ademais, notou-se distanciamento dos serviços de saúde do ambiente escolar, além da dificuldade de familiares e trabalhadores na abordagem do problema. Nesse contexto, propôs-se o programa intersetorial “Adolescer com Saúde” com o objetivo de capacitar familiares e trabalhadores escolares para lidar com tal problemática. Considerações Finais: O programa favoreceu a aproximação entre profissionais de saúde, da educação e familiares, fomentando a corresponsabilização pela promoção da saúde do adolescente.
Avaliação de incapacidade em pessoas com doença falciforme
Authors: Borges Carine de Lima , Jesus Gilmar Mercês de , Silva Lea Barbetta Pereira da , Carvalho Evanilda Souza de Santana
Published: February 2024

A expectativa de vida das pessoas com doença falciforme (DF) é baixa, e o agravamento da condição de saúde é frequente, gerando incapacidades. Todavia, pouco é conhecido sobre tais incapacidades com base na Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF). Assim, o objetivo do estudo foi descrever as incapacidades de adultos com DF. Realizou-se um estudo transversal descritivo, com 60 adultos com DF, de ambos os sexos. Informações sociodemográficas, fatores clínicos relacionados ao tipo de DF foram autorreferidos pelos participantes. As incapacidades foram avaliadas por meio da Escala de Avaliação de Incapacidade da Organização Mundial da Saúde (WHODAS 2.0) nos seguintes domínios: cognição, mobilidade, autocuidado, relações interpessoais (convivência com as pessoas), atividades de vida e participação na sociedade. Em cada domínio, foi definida incapacidade quando o sujeito relatou dificuldade leve, moderada, grave ou extrema de desempenhar a tarefa. Os dados foram analisados por estatística descritiva (frequências relativas). Os resultados mostraram valores elevados em todos os domínios avaliados, com destaque para dificuldades de concentração (90%) e desempenho nas tarefas domésticas (93,3%) e impacto da situação de saúde nas finanças do sujeito/família (96,7%). Os dados deste estudo mostraram que adultos com DF apresentam elevados índices de incapacidade, especialmente no domínio cognitivo, nas atividades de vida e na participação social.
Propuesta de instrumento de valoración de la gestión del conocimiento organizacional
Authors: Castellanos Narciso José Ever , Vega Guerrero Juan Camilo
Published: February 2024

La ponencia tiene como propósito presentar una propuesta de instrumento para evaluar la gestión del cocimiento organizacional. El documento parte de la identificación de los componentes y elementos teóricos a valorar en el instrumento mediante el análisis de contenidos en investigaciones relacionadas con gestión de conocimiento para así mismo identificar y extraer las variables que se necesita trabajar en el instrumento de investigación, como: la cultura organizacional, la estructura organizacional, el liderazgo directivo, el entorno, los niveles de madurez, los procesos de gestión del conocimiento y la tecnología. De igual manera, en los análisis de resultados se muestran las variables que se trabajarán en el instrumento de investigación, al igual que una tabla donde se recogen las subvariables a trabajar al igual que los principales aportes de los expertos en metodología. La discusión de los resultados permite establecer que existen siete áreas claves que se deben valorar en la estructura del instrumento: estrategia, tecnología, liderazgo, estructura organizacional, cultura y entorno. Por último, se presentan las conclusiones del ejercicio.