bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving hypertension awareness and management in Vietnam through a community-based model
Authors: McGuire Helen , Van Truong Bui , Thi Thu Hien Le , Nguyen Thanh Huyen , Murray Marge , Shellaby Jason , Aerts Ann , George Roshini , Hodges Mary
Published: November 2022

Hypertension prevalence in Vietnam is high, but few people are aware of their disease status. Detection, diagnosis, and treatment are limited, so new approaches are needed to improve awareness and manage the condition, especially at the primary health care level. The Communities for Healthy Hearts programme operated in four districts of Ho Chi Minh City, with the aim of increasing awareness and ensuring linkage to care. Interventions focused on extending services beyond health facilities to convenient community locations; training cadres of community volunteers to screen, refer, and follow up with clients; training health workers in facilities to diagnose, educate, and manage patients referred from the community; and supporting the process with digital case tracking. Community-based blood pressure screenings took place in client homes, commune health stations, and non-traditional sites such as coffee shops, dentists’ offices, marketplaces, neighbourhood watch/security posts, and tailor shops. In total, 121,273 adults aged 40 and older were screened. Of these, 25.1% had elevated blood pressure or a previous hypertension diagnosis and were referred to health facilities. Of those referred, 56.2% were confirmed to have hypertension, and of those confirmed, 75.2% were treated. Of those treated, 51.0% achieved blood pressure control, a favourable outcome over past programmes.
Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations
Authors: Jacobsen Henning , Strengert Monika , Maaß Henrike , Ynga Durand Mario Alberto , Katzmarzyk Maeva , Kessel Barbora , Harries Manuela , Rand Ulfert , Abassi Leila , Kim Yeonsu , Lüddecke Tatjana , Metzdorf Kristin , Hernandez Pilar , Ortmann Julia , Heise Jana-Kristin , Castell Stefanie , Gornyk Daniela , Glöckner Stephan , Melhorn Vanessa , Kemmling Yvonne , Lange Berit , Dulovic Alex , Marsall Patrick , Häring Julia , Junker Daniel , Schneiderhan-Marra Nicole , Hoffmann Markus , Pöhlmann Stefan , Krause Gérard , Cicin-Sain Luka
Published: November 2022

SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron BA.1 and its sub-lineages have the largest number of amino acid alterations in its Spike protein to date. Thus, they may efficiently escape recognition by neutralizing antibodies, allowing breakthrough infections in convalescent and vaccinated individuals in particular in those who have only received a primary immunization scheme. We analyzed neutralization activity of sera from individuals after vaccination with all mRNA-, vector- or heterologous immunization schemes currently available in Europe by in vitro neutralization assay at peak response towards SARS-CoV-2 B.1, Omicron sub-lineages BA.1, BA.2, BA.2.12.1, BA.3, BA.4/5, Beta and Delta pseudotypes and also provide longitudinal follow-up data from BNT162b2 vaccinees. All vaccines apart from Ad26.CoV2.S showed high levels of responder rates (96–100%) towards the SARS-CoV-2 B.1 isolate, and minor to moderate reductions in neutralizing Beta and Delta VoC pseudotypes. The novel Omicron variant and its sub-lineages had the biggest impact, both in terms of response rates and neutralization titers. Only mRNA-1273 showed a 100% response rate to Omicron BA.1 and induced the highest level of neutralizing antibody titers, followed by heterologous prime-boost approaches. Homologous BNT162b2 vaccination, vector-based AZD1222 and Ad26.CoV2.S performed less well with peak responder rates of 48%, 56% and 9%, respectively. However, Omicron responder rates in BNT162b2 recipients were maintained in our six month longitudinal follow-up indicating that individuals with cross-protection against Omicron maintain it over time. Overall, our data strongly argue for booster doses in individuals who were previously vaccinated with BNT162b2, or a vector-based primary immunization scheme.
Significance of seed dispersal by the largest frugivore for large-diaspore trees
Authors: Sato Hiroki
Published: November 2022

How do large-bodied frugivores contribute to seed dispersal of large-diaspore plants? This study examined seed dispersal effectiveness for two large-diaspore tree species, Astrotrichilia asterotricha (AA) and Abrahamia deflexa (AD), in a Madagascan forest. I evaluated fruit removal rates through focal tree observations and factors affecting seedling recruitment up to the 2-year-old seedling stage. I confirmed brown lemur (Eulemur fulvus) as the sole disperser, removing 58.8% and 26.0% of fruits produced by AA and AD. Brown lemurs frequently visited large-crowned AA trees with high density of fallen fruits and more adjacent fruiting trees during seasons with low fruit diversity. Most AA seedlings were removed by predators, although canopy openness slightly improved seedling establishment. Although AD seeds were severely attacked by predators under mother trees, the seedlings survived under dispersal conditions distant from the mother trees, and with low density of diaspores. AD had a higher cumulative probability from fruit removal to seedling recruitment (6.5%) than AA (1.5%) in the first rainy season. This study clarifies the significance of seed dispersal to tree recruitment strategies, which vary among different combinations of tree species and large frugivores, i.e. quantitative dispersal to reach suitable microhabitats, and qualitative dispersal to escape from dangerous zones near mother trees.
Identification of noninvasive diagnostic biomarkers for ectopic pregnancy using data-independent acquisition (DIA)proteomics: a pilot study
Authors: Ma Dan , Yang Ruiqing , Chen Yunlong , Huang Zhengyi , Shen Yuxin , He Chengqi , Zhao Lixing
Published: November 2022

At present, the diagnosis of ectopic pregnancy mainly depends on transvaginal ultrasound and β-hCG. However, these methods may delay diagnosis and treatment time. Therefore, we aimed to screen for serological molecular markers for the early diagnosis of ectopic pregnancy (EP).Using data-independent acquisition (DIA)proteomics, the differential proteins in serum were selected between the intrauterine pregnancy (IP) and EP groups. Then, the expression levels of these differential proteins were measured by enzyme-linked immunosorbent assay. The diagnostic value of the serum biomarkers was evaluated by receiver operating characteristic curve analysis.GSTO1, ECM-1 and β-hCG showed significant differences between the EP and IP groups (P < 0.05). The combination of GSTO1/ECM-1/β-hCG had an area under the curve of 0.93 (95% CI 0.88–0.99), a sensitivity of 88.89% (95% CI 73.94–96.89) and a specificity of 86.11% (95% CI 70.50–95.33) with a likelihood ratio of 6.40.The combination of GSTO1/ECM-1/β-hCG may be developed into a possible approach for the early diagnosis of EP.
Insights into the equilibrium structure and translocation mechanism of TP1, a spontaneous membrane-translocating peptide
Authors: Muñoz-Gacitúa Diego , Guzman Fanny , Weiss-López Boris
Published: November 2022

Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid. Although many solutions have been proposed to overcome this barrier, arguably the most promising solution is the use of cell-penetrating peptides. Recently, an array of hydrophobic penetrating peptides was discovered via high throughput screening which proved to be able to cross the membrane passively, and although these peptides proved to be effective at penetrating the cell, the details behind the underlying mechanism of this process remain unknown. In this study, we developed a method to find the equilibrium structure at the transmembrane domain of TP1, a hydrophobic penetrating peptide. In this method, we selectively deuterium-label amino acids in the peptidic chain, and employ results of $$^2$$

2

H-NMR spectroscopy to find a molecular dynamics simulation of the peptide that reproduces the experimental results. Effectively finding the equilibrium orientation and dynamics of the peptide in the membrane. We employed this equilibrium structure to simulate the entire translocation mechanism and found that after the peptide reaches its equilibrium structure, it must undergo a two-step mechanism in order to completely translocate the membrane, each step involving the flip-flop of each arginine residue in the peptide. This leads us to conclude that the RLLR motif is essential for the translocating activity of the peptide.
The utility of the emBODY tool as a novel method of studying complex phenomena-related emotions
Authors: Herman Aleksandra M. , Zaremba Dominika , Kossowski Bartosz , Marchewka Artur
Published: November 2022

Bodily sensations are one of the major building blocks of emotional experience. However, people differ in their ability to recognise and name their emotions, especially those in response to complex phenomena such as climate change or the COVID-19 pandemic. Therefore, we investigated whether the bodily sensation maps (BSMs) approach can be employed to study emotions related to phenomena that are likely to evoke various, and perhaps even conflicting, emotions in people. Using a unique topographical self-report method—the previously established emBODY tool, 548 participants marked where in the body they feel sensations (activations and deactivations) when they experience distinct emotions (e.g. happiness) and when they think about different phenomena, namely climate change, COVID-19 pandemic, war, nature, friends, and summer holidays. We revealed maps of bodily sensations associated with different emotions and phenomena. Importantly, each phenomenon was related to a statistically unique BSM, suggesting that participants were able to differentiate between feelings associated with distinct phenomena. Yet, we also found that BSMs of phenomena showed some similarity with maps of emotions. Together, these findings indicate that the emBODY tool might be useful in uncovering the range of emotions individuals experience towards complex phenomena.
4D flow MRI in abdominal vessels: prospective comparison of k-t accelerated free breathing acquisition to standard respiratory navigator gated acquisition
Authors: Bane Octavia , Stocker Daniel , Kennedy Paul , Hectors Stefanie J. , Bollache Emilie , Schnell Susanne , Schiano Thomas , Thung Swan , Fischman Aaron , Markl Michael , Taouli Bachir
Published: November 2022

Volumetric phase-contrast magnetic resonance imaging with three-dimensional velocity encoding (4D flow MRI) has shown utility as a non-invasive tool to examine altered blood flow in chronic liver disease. Novel 4D flow MRI pulse sequences with spatio-temporal acceleration can mitigate the long acquisition times of standard 4D flow MRI, which are an impediment to clinical adoption. The purpose of our study was to demonstrate feasibility of a free-breathing, spatio-temporal (k−t) accelerated 4D flow MRI acquisition for flow quantification in abdominal vessels and to compare its image quality, flow quantification and inter-observer reproducibility with a standard respiratory navigator-gated 4D flow MRI acquisition. Ten prospectively enrolled patients (M/F: 7/3, mean age = 58y) with suspected portal hypertension underwent both 4D flow MRI acquisitions. The k−t accelerated acquisition was approximately three times faster (3:11 min ± 0:12 min/9:17 min ± 1:41 min, p < 0.001) than the standard respiratory-triggered acquisition. Vessel identification agreement was substantial between acquisitions and observers. Average flow had substantial inter-sequence agreement in the portal vein and aorta (CV < 15%) and poorer agreement in hepatic and splenic arteries (CV = 11–38%). The k−t accelerated acquisition recorded reduced velocities in small arteries and reduced splenic vein flow. Respiratory gating combined with increased acceleration and spatial resolution are needed to improve flow measurements in these vessels.
CaMKII regulates neuromuscular activity and survival of the human blood fluke Schistosoma mansoni
Authors: Hirst Natasha L. , Lawton Scott P. , Walker Anthony J.
Published: November 2022

Calcium/calmodulin dependant protein kinase II (CaMKII), an important transducer of Ca2+ signals, orchestrates multiple cellular functions in animals. Here we investigated the importance of CaMKII to Schistosoma mansoni, a blood parasite that causes human schistosomiasis. We demonstrate that phosphorylated (activated) CaMKII is present in cercariae, schistosomula and adult worms, and show that striking activation occurs in the nervous tissue of these parasite life-stages; CaMKII was also activated in the tegument and muscles of adult worms and the vitellaria of females. Exposure of worms to the anti-schistosomal drug praziquantel (PZQ) induced significant CaMKII activation and depletion of CaMKII protein/activation in adult worms resulted in hypokinesia, reduced vitality and death. At medium confidence (global score ≥ 0.40), S. mansoni CaMKII was predicted to interact with 51 proteins, with many containing CaMKII phosphorylation sites and nine mapped to phosphoproteome data including sites within a ryanodine receptor. The CaMKII network was functionally enriched with mitogen-activated protein kinase, Wnt, and notch pathways, and ion-transport and voltage-dependent channel protein domains. Collectively, these data highlight the intricacies of CaMKII signalling in S. mansoni, show CaMKII to be an active player in the PZQ-mediated response of schistosomes and highlight CaMKII as a possible target for the development of novel anti-schistosome therapeutics.
Customizing the mechanical properties of additively manufactured metallic meta grain structure with sheet-based gyroid architecture
Authors: Kim Kibeom , Kim Gun-hee , Kim Hyung Giun , Kim Hoe Joon , Kim Namjung
Published: November 2022

The use of cellular structures has led to unprecedented outcomes in various fields involving optical and mechanical cloaking, negative thermal expansion, and a negative Poisson’s ratio. The unique characteristics of periodic cellular structures primarily originate from the interconnectivity, periodicity, and unique design of the unit cells. However, the periodicity often induces unfavorable mechanical behaviors such as a “post-yielding collapse”, and the mechanical performance is often limited by the design of the unit cells. Therefore, we propose a novel structure called a meta grain structure (MGS), which is inspired by a polycrystalline structure, to enhance flexibility in design and mechanical reliability. A total of 138 different MGSs were built and tested numerically, and the correlations between the design parameters (e.g., the relative density) and mechanical properties of the MGSs were rigorously analyzed. A systematic design methodology was developed to obtain the optimal design of the MGS with the target Young’s modulus. This methodology makes it possible to build a unique structure that offers various design options and overcomes the current limitations of cellular structures. Furthermore, a systematic inverse design methodology makes it possible to produce an MGS that satisfies the required mechanical performance.
Cardiovascular responses to orthostasis during a simulated 3-day heatwave
Authors: Fisher Jason T. , Ciuha Urša , Ioannou Leonidas G. , Simpson Lydia L. , Possnig Carmen , Lawley Justin , Mekjavic Igor B.
Published: November 2022

Global warming has caused an increase in the frequency, duration, and intensity of summer heatwaves (HWs). Prolonged exposure to hot environments and orthostasis may cause conflicting demands of thermoregulation and blood pressure regulation on the vasomotor system, potentially contributing to cardiovascular complications and occupational heat strain. This study assessed cardiovascular and skin blood flow (SkBF) responses to orthostasis before, during and after a 3-day simulated HW. Seven male participants maintained a standard work/rest schedule for nine consecutive days split into three 3-day parts; thermoneutral pre-HW (25.4 °C), simulated HW (35.4 °C), thermoneutral post-HW. Gastrointestinal (Tgi) and skin (Tsk) temperatures, cardiovascular responses, and SkBF were monitored during 10-min supine and 10-min 60° head-up tilt (HUT). SkBF, indexed using proximal–distal skin temperature gradient (∆TskP-D), was validated using Laser-Doppler Flowmetry (LDF). The HW significantly increased heart rate, cardiac output and SkBF of the leg in supine; HUT increased SkBF of the arm and leg, and significantly affected all cardiovascular variables besides cardiac output. Significant regional differences in SkBF presented between the arm and leg in all conditions; the arm displaying vasodilation throughout, while the leg vasoconstricted in non-HW before shifting to vasodilation in the HW. Additionally, ∆TskP-D strongly correlated with LDF (r = −.78, p < 0.001). Prolonged HW exposure and orthostasis, individually, elicited significant changes in cardiovascular and SkBF variables. Additionally, varying regional blood flow responses were observed, suggesting the upper and lower vasculature receives differing vasomotor control. Combined cardiovascular alterations and shifts towards vasodilation indicate an increased challenge to industrial workers during HWs.
Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer
Authors: Jamshidi-adegani Fatemeh , Ghaemi Shokoofeh , Al-Hashmi Sulaiman , Vakilian Saeid , Al-kindi Juhaina , Rehman Najeeb Ur , Alam Khurshid , Al-Riyami Khamis , Csuk Rene , Arefian Ehsan , Al-Harrasi Ahmed
Published: November 2022

This study aimed to compare the effect of Boswellic acid derivatives on the viability, apoptosis, and epigenomic profiling of breast cancer. According to the viability assays, 3-O-acetyl-11-keto-β-Boswellic acid (AKBA) showed more toxicity against MDA-MB-231 cells when compared with the 3-O-acetyl-β-Boswellic acid (ABA). In contrast, ABA revealed less toxicity against MCF-10A. Cell cycle and apoptosis assays determined the maximum apoptotic effect of AKBA on MCF-7, and MDA-MB-231 cells. Interestingly, β-Boswellic acid (BA) and ABA did not promote the apoptosis in MCF-10A cells. Transwell migration assay indicated the greatest normalized inhibition (around 160%) in the migration of MDA-MB-231 cells induced by AKBA. The expression of P53, BAX, and BCL2 genes in cancerous cell lines has affirmed that both AKBA and ABA could induce the maximal apoptosis. Western-blot investigation demonstrated that the maximum over-expression of P53 protein (1.96 times) was caused by AKBA in MDA-MB-231 cells, followed by ABA in MCF-7 cells. The BCL2 protein expression was in agreement with the previously reported results. The global DNA methylation in both cancerous cells was reduced by ABA. These results suggest that ABA represented more epigenetic modulatory effect while AKBA shows more cytotoxic and apoptotic effect against breast cancer cell lines.
Beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in tafazzin knockdown mice
Authors: Russo Silvia , De Rasmo Domenico , Signorile Anna , Corcelli Angela , Lobasso Simona
Published: November 2022

Barth Syndrome (BTHS), a genetic disease associated with early-onset cardioskeletal myopathy, is caused by loss-of-function mutations of the TAFAZZIN gene, which is responsible for remodeling the mitochondrial phospholipid cardiolipin (CL). Deregulation of CL biosynthesis and maturation in BTHS mitochondria result in a dramatically increased monolysocardiolipin (MLCL)/CL ratio associated with bioenergetic dysfunction. One of the most promising therapeutic approaches for BTHS includes the mitochondria-targeted tetrapeptide SS-31, which interacts with CL. Here, we used TAFAZZIN knockdown (TazKD) mice to investigate for the first time whether in vivo administration of SS-31 could affect phospholipid profiles and mitochondrial dysfunction. The CL fingerprinting of TazKD cardiac mitochondria obtained by MALDI-TOF/MS revealed the typical lipid changes associated with BTHS. TazKD mitochondria showed lower respiratory rates in state 3 and 4 together with a decreased in maximal respiratory rates. Treatment of TazKD mice with SS-31 improved mitochondrial respiratory capacity and promoted supercomplex organization, without affecting the MLCL/CL ratio. We hypothesize that SS-31 exerts its effect by influencing the function of the respiratory chain rather than affecting CL directly. In conclusion, our results indicate that SS-31 have beneficial effects on improving cardiac mitochondrial dysfunction in a BTHS animal model, suggesting the peptide as future pharmacologic agent for therapy.
Comparing postoperative outcomes of two fully hydroxyapatite-coated collarless stems in total hip arthroplasty through propensity score matching analysis with 2 years follow-up
Authors: Imagama Takashi , Matsuki Yuta , Kaneoka Takehiro , Kawakami Takehiro , Seki Kazushige , Seki Toshihiro , Hirata Kenji , Okazaki Tomoya , Tanaka Hiroshi , Sakai Takashi
Published: November 2022

A fully hydroxyapatite (HA)-coated stem such as Corail stem, that compacts the cancellous bone around the stem in total hip arthroplasty (THA), is reported to have good long-term results for more than 20 years. Although various fully HA-coated stems have being used recently, it is unclear whether there are differences in the postoperative outcomes. In this study, 224 patients (234 hips) with THA using either the Corail collarless stem or the Hydra stem were enrolled. And then we performed a retrospective comparison of the data at 2 years postoperatively using propensity score matching analysis. The postoperative modified Harris hip scores in 84 hips each group were 93.6 ± 8.2 points in the Corail group and 92.8 ± 10.1 points in the Hydra group, and there was no significant difference between the two groups. However, there was significantly less stem subsidence and rate of 3rd degree or greater stress shielding in the Corail group. Although these two stems were similar collarless fully HA-coated stems and clinical outcomes were favorable results in both groups at 2 years postoperatively, radiographic evaluations showed statistically significant differences between the two groups.
Magnetic ground states of honeycomb lattice Wigner crystals
Authors: Kaushal Nitin , Morales-Durán Nicolás , MacDonald Allan H. , Dagotto Elbio
Published: November 2022

Lattice Wigner crystal states stabilized by long-range Coulomb interactions have recently been realized in two-dimensional moiré materials. We employ large-scale unrestricted Hartree-Fock techniques to unveil the magnetic phase diagrams of honeycomb lattice Wigner crystals. For the three lattice filling factors with the largest charge gaps, $$n=2/3,1/2,1/3$$
n
=
2
/
3
,
1
/
2
,
1
/
3
, the magnetic phase diagrams contain multiple phases, including ones with non-collinear and non-coplanar spin arrangements. We discuss magnetization evolution with external magnetic field, which has potential as an experimental signature of exotic spin states. Our theoretical results could potentially be validated in moiré materials formed from group VI transition metal dichalcogenide twisted homobilayers.
Weak localisation driven by pseudospin-spin entanglement
Authors: Sousa Frederico , Perkins David T. S. , Ferreira Aires
Published: November 2022

At low temperatures, quantum corrections, originating from the interference of the many paths an electron may take between two points, tend to dominate the transport properties of two-dimensional conductors. These quantum corrections increase the resistivity in systems such as two-dimensional electron gases (2DEGs) without spin–orbit coupling (SOC), a phenomenon called weak localisation. Including symmetry-breaking SOC leads to a change from weak localisation (WL) to weak anti-localisation (WAL) of the electronic states, i.e. a WL-to-WAL transition. Here, we revisit the Cooperon, the propagator encoding quantum corrections, within the context of ultra-clean graphene-based van der Waals heterostructures with strong symmetry-breaking Bychkov-Rashba SOC to yield two completely counter-intuitive results. Firstly, we find that quantum corrections vary non-monotonically with the SOC strength, a clear indication of non-perturbative physics. Secondly, we observe the exact opposite of that seen in 2DEGs with strong SOC: a WAL-to-WL transition. This dramatic reversal is driven by mode entanglement of the pseudospin and spin degrees of freedom describing graphene’s electronic states. We obtain these results by constructing a non-perturbative treatment of the Cooperon, and observe distinct features in the SOC dependence of the quantum corrections to the electrical conductivity that would otherwise be missed by standard perturbative approaches.
Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis
Authors: Palermo Francesca , Pieroni Nicola , Sanna Alessia , Parodi Benedetta , Venturi Consuelo , Begani Provinciali Ginevra , Massimi Lorenzo , Maugeri Laura , Marra Gian Paolo , Longo Elena , D’Amico Lorenzo , Saccomano Giulia , Perrin Jonathan , Tromba Giuliana , Bukreeva Inna , Fratini Michela , Gigli Giuseppe , Kerlero de Rosbo Nicole , Cedola Alessia
Published: November 2022

The 3D complexity of biological tissues and intricate structural-functional connections call for state-of-the-art X-ray imaging approaches to overcome limitations of classical imaging. Unlike other imaging techniques, X-ray phase-contrast tomography (XPCT) offers a highly sensitive 3D imaging approach to investigate different disease-relevant networks at levels ranging from single cell through to intact organ. We present here a concomitant study of the evolution of tissue damage and inflammation in different organs affected by the disease in the murine model for multiple sclerosis, a demyelinating autoimmune disorder of the central nervous system. XPCT identifies and monitors structural and cellular alterations throughout the central nervous system, but also in the gut, and eye, of mice induced to develop multiple sclerosis-like disease and sacrificed at pre-symptomatic and symptomatic time points. This study details the sequential evolution of multi-organ damages in the murine multiple sclerosis model showing the disease development and progression which is of relevance for the human case.
Fischer–Tropsch Catalysts
Authors: Becker H. , Wein K. , Güttel R.
Published: November 2022

Catalysts for biomass-to-liquid applications via Fischer–Tropsch synthesis need to be robust in terms of synthesis gas composition and should provide an attractive product spectrum to be implemented in the subsequent value chain. This chapter focuses on strategies to design catalysts, with a focus on current developments for active and support materials, as well as structuring and formulation. The following are discussed in particular: the ability of materials to cope with a high oxygen load and poisoning impurities in the synthesis gas; the ability to withstand deactivation processes; approaches to tailoring the product spectrum. Therefore, the impact of the structure and geometry of the catalysts is elaborated on, as well as promising combinations of active and supporting compounds. Hence, the chapter provides a link between material design, catalyst geometry and the reactor scale, while emphasising the Fischer–Tropsch catalyst.
Biomass to Liquid-syngas to Olefins
Authors: Liu Sixu , Wu Danfeng , Lin Binyong , Li Jinlin , Xiong Haifeng
Published: November 2022

Lower olefins are important building blocks in the chemical industry that are used to produce plastics and chemicals. The conversion of syngas to lower olefins is a promising route for this process, and this chapter discusses two types of catalysts used for efficient production of lower olefins from syngas.
Environmental routes of virus transmission and the application of nanomaterial-based sensors for virus detection
Authors: Wang Wei , Kang Seju , Zhou Wei , Vikesland Peter J.
Published: November 2022

Many outbreaks of emerging disease (e.g., avian influenza, COVID-19) are enhanced by the environmental dissemination of viruses. Nanotechnology enabled tools have the potential to detect viruses in complex environmental matrices.
Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet
Authors: Wang Yu , Li Ting , Liu Yueyue , Yang Chengcheng , Liu Lei , Zhang Xiangnan , Yang Xingbin
Published: November 2022

Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet.
Hyper crosslinked polymer supported NHC stabilized gold nanoparticles with excellent catalytic performance in flow processes
Authors: Eisen Constantin , Ge Lingcong , Santini Elena , Chin Jia Min , Woodward Robert T. , Reithofer Michael R.
Published: November 2022

Gold nanoparticles stabilized in a HCP·NHC network showing excellent catalytic activity in flow application.
Enhancement of self-trapped excitons and near-infrared emission in Bi3+/Er3+ co-doped Cs2Ag0.4Na0.6InCl6 double perovskite
Authors: Dave Kashyap , Huang Wen-Tse , Leśniewski Tadeusz , Lazarowska Agata , Grzegorczyk Maciej , Mahlik Sebastian , Leniec Grzegorz , Kaczmarek Sławomir M. , Liu Ru-Shi
Published: November 2022

Self-trapped exciton-derived energy transfer is a possible strategy to enhance the emission of Er at 1540 nm in lead-free double perovskite structures.
Potential use of bioactive nanofibrous dural substitutes with controlled release of IGF-1 for neuroprotection after traumatic brain injury
Authors: Wang Yue , Guo Qingxia , Wang Wei , Wang Yuanfei , Fang Kuanjun , Wan Qi , Li Huanting , Wu Tong
Published: November 2022

Primary neuron survival after neurite transection (left) or OGD (right) injuries using a bioactive nanofibrous dural substitute.
A new TIFSIX anion pillared metal organic framework with abundant electronegative sites for efficient C2H2/CO2separation
Authors: Xu Nuo , Yan Tongan , Li Jiahao , Wang Lingyao , Liu Dahuan , Zhang Yuanbin
Published: November 2022

A new TIFSIX anion pillared metal organic framework ZNU-7 (ZNU = Zhejiang Normal University) with abundant electronegative sites was prepared for efficient C2H2/CO2separation.
Label-free plasmonic-based biosensing using a gold nanohole array chip coated with a wafer-scale deposited WS2monolayer
Authors: Kang Lixing , Zhang Yan , Gong Qian , Das Chandreyee Manas , Shao Huilin , Poenar Daniel Puiu , Coquet Philippe , Yong Ken-Tye
Published: November 2022

This paper reports a novel plasmonic sensor chip made up of a gold nanohole array chip coated with a WS2monolayer, which is then functionalized for the detection of protein–protein interactions.
Simultaneous improvement of the thermostability and activity of lactic dehydrogenase from Lactobacillus rossiae through rational design
Authors: Luo Xi , Wang Yifeng , Zheng Weilong , Sun Xiaolong , Hu Gaowei , Yin Longfei , Zhang Yingying , Yin Fengwei , Fu Yongqian
Published: November 2022

The d-LDH was engineered using computationally-assisted rational mutagenesis. The two mutants D249A and D249A/T247I showed significantly enhanced thermostability and catalytic activity to sodium phenylpyruvate compared with the wild-type enzyme.
Curcumin loaded Ag–TiO2-halloysite nanotubes platform for combined chemo-photodynamic therapy treatment of cancer cells
Authors: Nyankson Emmanuel , Awuzah Dominic , Tiburu Elvis K. , Efavi Johnson K. , Agyei-Tuffour Benjamin , Paemka Lily
Published: November 2022

The synergy between photogenerated reactive oxygen species and the anticancer potency of curcumin was examined by exposing HeLa cancer cells to irradiated curcumin loaded halloysite nanotubes-Ag–TiO2 nanomaterial. 0% cell viability was obtained.
Quantification of clofarabine in urine and plasma by LC-MS/MS: suitable for PK study and TDM in pediatric patients with relapsed or refractory ALL
Authors: Zhang Xi , Jia Xinbei , Tong Weihang , Chen Hui , Lei Ning , Li Guangrun , Tai Jun , Li Pengfei
Published: November 2022

Clofarabine is approved for the treatment of relapsed or refractory acute lymphoblastic leukemia (ALL) in pediatric patients aged 1 to 21 years.
The stable “F–SO2+” donor provides a mild and efficient approach to nitriles and amides
Authors: Cui Yin , Zhao Yiyong , Shen Junjie , Zhang Guofu , Ding Chengrong
Published: November 2022

In this update, we developed a mild, efficient and practical method using stable “F–SO2+” donor A as an environment friendly promoter for conversion of oximes to nitriles or amides via β-elimination or Beckmann rearrangement in excellent yields.
Fly ash geopolymer as a coating material for controlled-release fertilizer based on granulated urea
Authors: Hamidi Rashidah Mohamed , Siyal Ahmer Ali , Luukkonen Tero , Shamsuddin Rashid M. , Moniruzzaman Muhammad
Published: November 2022

The effect of fly ash particle size and solid to liquid ratio on the performance of geopolymer as a coating material for controlled release urea was investigated. Geopolymer coated urea completely released in 132 minutes in water and 15 days in soil.
Highly selective NH3 gas sensor based on Co(OH)2/Ti3C2Tx nanocomposites operating at room temperature
Authors: Huang Bo , Zhao Zhihua , Chen Pu , Zhou Baocang , Chen Zhuo , Fu Yu , Zhu Hongyu , Chen Chen , Zhang Shuaiwen , Wang Anbiao , Shi Pu , Shen Xiaoqing
Published: November 2022

The prepared Co(OH)2@Ti3C2Tx composite shows good gas sensing performance for ammonia at room temperature, making it a promising candidate for a practical detector for NH3.
Tb3+ and Sm3+ co-doped Ca2La3(SiO4)3F phosphor: synthesis, color regulation, and luminescence properties
Authors: Nie Kun , Zhou Ranran , Cheng Chi-An , Duan Xiuqiang , Hu Ziyao , Mei Lefu , Liu Haikun , Wang Luoxin , Wang Hua , Ma Xiaoxue
Published: November 2022

The photoluminescence spectra of Ca2La2.85−x(SiO4)3F:0.15Tb3+,xSm3+ phosphors (left) could emit typical multicolor light with increasing doping contents of samarium (right).
Structural, electrical, and dielectric study of the influence of 3.4% lanthanide (Ln3+ = Sm3+ and La3+) insertion in the A-site of perovskite Ba0.95Ln0.034Ti0.99Zr0.01O3
Authors: Yahakoub El Hassan , Bendahhou Amine , Chourti Karim , Chaou Fatima , Jalafi Ilyas , El Barkany Soufian , Bahari Zahra , Abou-salama Mohamed
Published: November 2022

This paper presents a systematic study of the substitution effect by lanthanides (Ln3+ = Sm3+ and La3+) in the A-site of perovskite Ba(1−x)Ln2x/3(Ti0.99Zr0.01)O3 with a substitution rate equal to 3.4%.
Tribological gain enabled by the synergy of copper nanoparticles and friction induced in situ tribo-click reaction
Authors: Xu Hao-Zhe , Bao Luyao , Wang Xin-Gang , Dong Rui , Xie Ao , Yu Qiangliang , Chen Qiang , Cai Meirong , Zhou Feng , Liang Yong-Min , Liu Weimin
Published: November 2022

Through the synergy of friction and copper nanoparticles, the targeted introduction of click chemistry is achieved during the steel–steel friction process, which then acts on the friction process to achieve satisfactory tribological gains.
Rational design of a phenothiazine-based donor–acceptor covalent organic framework for enhanced photocatalytic oxidative coupling of amines and cyclization of thioamides
Authors: Liu Yang , Jiang Xinyue , Chen Likun , Cui Yan , Li Qiu-Yan , Zhao Xinsheng , Han Xiguang , Zheng Yong-Chao , Wang Xiao-Jun
Published: November 2022

A PTZ-based D–A COF with low exciton binding energy and high charge separation efficiency exhibited an enhanced photocatalytic performance in oxidative amine coupling and cyclization of thioamide reactions.
Dual-responsive jumping actuators by light and humidity
Authors: Li Jingjing , Wang Meilin , Cui Zhanpeng , Liu Shiyong , Feng Danyang , Mei Guangkai , Zhang Rui , An Baigang , Qian Dong , Zhou Xiang , Liu Zunfeng
Published: November 2022

This paper develops an actuator by mimicking the makeup application process and achieves jumping under moisture stimuli and directional controlled jumping with an asymmetric structural design under NIR light inspired by frog jumping.
Inspired by the Cu-driven conversion reaction: how anionic properties dictate the electrochemical performance of vanadium sulfide
Authors: Yang Wenjuan , Wang Kaihong , Zhou Wenbo , Luo Ningjing , Huang Shuping , Li Yafeng , Hui Kwun Nam , Wei Mingdeng
Published: November 2022

The anionic properties of electrolytes play a significant role in determining the electrochemical performance of VS2/SNC anodes, which is interpreted from the angle of solvation effect and corresponding electrode/electrolyte interface properties.
Boosted charge separation in direct Z-scheme heterojunctions of CsPbBr3/Ultrathin carbon nitride for improved photocatalytic CO2reduction
Authors: Luo Fanqi , Liu Mingyang , Zheng Mang , Li Qi , Wang Hong , Zhou Jing , Jiang Yong , Yu Yaoguang , Jiang Baojiang
Published: November 2022

A direct Z-scheme 2D/2D heterojunction of CsPbBr3/g-C3N4was fabricatedviaa simple electrostatic self-assembly process, which exhibited a remarkably photocatalytic performance for converting CO2and H2O to CH4.
Voltage hysteresis loop as a fingerprint of slow kinetics Co2+-to-Co3+ transition in layered NaxCox/2Ti1−x/2O2 cathodes for sodium batteries
Authors: Mikhailova Daria , Gorbunov Mikhail V. , An Nguyen Hoang Bao , Pohle Björn , Maletti Sebastian , Heubner Christian
Published: November 2022

The P2- and O3-Na0.67Co0.33Ti0.67O2 cathodes undergo a very slow transformation during charge and discharge in sodium batteries due to a valence and spin-state transition of cobalt cations. As a result, a big potential hysteresis of 2.5–3 V arises.
Vascularized dental pulp regeneration using cell-laden microfiber aggregates
Authors: Liang Qingqing , Liang Cheng , Liu Xiaojing , Xing Xiaotao , Ma Shixing , Huang Haisen , Liang Chao , Liu Lei , Liao Li , Tian Weidong
Published: November 2022

Schematic illustration of cell-laden microfiber aggregates for pulp regeneration. (A) The fabrication process of DPSC-laden and HUVEC-laden microfibers. (B) Cell-laden microfiber aggregates were filled into tooth roots for ectopic pulp regeneration.
Hybrid nano-architectures loaded with metal complexes for the co-chemotherapy of head and neck carcinomas
Authors: Santi Melissa , Frusca Valentina , Ermini Maria Laura , Mapanao Ana Katrina , Sarogni Patrizia , Gonnelli Alessandra , Giannini Noemi , Zamborlin Agata , Biancalana Lorenzo , Marchetti Fabio , Voliani Valerio
Published: November 2022

Developing strategies for the treatment of head and neck malignancies based on nano-structured co-chemotherapeutics is critical for the next cancer management.
Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion
Authors: Mao Huijia , Wen Yangyang , Yu Yonghui , Li Hongyan , Wang Jing , Sun Baoguo
Published: November 2022

The enhanced chemodynamic therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion.
A functionalized biological heart valve by double bond crosslinking with enhanced biocompatibility and antithrombogenicity
Authors: Zheng Cheng , Kuang Dajun , Ding Kailei , Huang Xueyu , Fan Hongsong , Yang Li , Wang Yunbing , Zhang Xingdong
Published: November 2022

A poly-2-hydroxyethyl methacrylate functionalized biological heart valve with enhanced biocompatibility, antithrombogenicity and anticalcification property.
Accelerated discovery of defect tolerant organo-halide perovskites
Authors: Işleyen N. , Corcor A. , Çakirefe S. , Ormanli N. , Kanat E. N. , Yavuz I.
Published: November 2022

A machine learning based, “accelerated” materials discovery strategy to predict the defects of HOIP-candidate materials is presented. We rationalize defect tolerant perovskite materials classification and structure-property relationships.
Design, fabrication and applications of flexible RFID antennas based on printed electronic materials and technologies
Authors: Yang Wendong , Cheng Xi , Guo Zihao , Sun Qianghao , Wang Jia , Wang Changhai
Published: November 2022

Recent advances in flexible printed RFID antennas are reviewed, with an emphasis on material categories and properties, fabricating technologies, structure design and applications.
Metal–organic gel coupled entropy-driven circuit for fluorescence detection of miR-155
Authors: Cao Li Ping , Wang Yao , Bai Yan , Jiang Yong Jian , Li Chun Mei , Li Yuan Fang , Huang Cheng Zhi , Zhen Shu Jun
Published: November 2022

We reported a novel strategy that combined a Cu-based metal–organic gel (Cu-MOG) with an entropy-driven circuit (EDC) to detect miR-155 as a proof-of-principle target.
Synthesis, crystal structure and white luminescence of zero-dimensional organic–inorganic zinc halides
Authors: Chen Qian , Dai Fangxu , Zhang Kai , Zhou Hong , Zhang Mingming , Quan Dong , Wang Lei , Xing Jun
Published: November 2022

Three new Zn-based organic–inorganic metal halides (C8H12N)2ZnBr4(1), (C9H14N)2ZnBr4(2), and (C9H14NO)2ZnBr4(3) were synthesized, and these crystals with zero-dimensional structures all show white emission.
The Effect of Phonological Overlap on English and Spanish Expressive Vocabulary
Authors: Tibbits Nicole , Lancaster Hope Sparks , de Diego-Lázaro Beatriz
Published: November 2022

Purpose:

This study examined the effect of phonological overlap on English and Spanish expressive vocabulary accuracy as measured by the bilingual Expressive One-Word Picture Vocabulary Test–Fourth Edition (EOWPVT-IV). We hypothesized that if languages interact during an expressive vocabulary task, then higher phonological overlap will predict higher expressive vocabulary accuracy, especially in the nondominant language.

Method:

Twenty English-dominant bilingual children (English–Spanish) completed the bilingual EOWPVT-IV. We calculated phonological overlap between 117 English and Spanish words included in the bilingual EOWPVT using the Crosslinguistic Overlap Scale for Phonology.

Results:

Generalized logistic mixed-effect models revealed that phonological overlap and word frequency predicted vocabulary accuracy in Spanish, in addition to item difficulty. Age and item difficulty were the only predictors of English accuracy.

Conclusions:

Phonological overlap was a significant predictor of Spanish vocabulary accuracy (the least dominant language of the children in our sample), suggesting a transfer between vocabulary in the dominant language into vocabulary in the least dominant language. Future studies should investigate how languages interact in bilingual children to provide us with information about how to create and administer vocabulary tests that represent vocabulary in each language and use vocabulary teaching strategies that promote dual language development.

Supplemental Material:

https://doi.org/10.23641/asha.21554838
Interaction network‐based resilient consensus of connected vehicles against cyber‐attacks
Authors: Liu Yonggui , Li Zeming , Guo Ge
Published: November 2022

The paper investigates a consensus problem of connected vehicle systems (CVSs) under cyber‐attacks. In real application, dynamics and amplitude of cyber attacks are unknown and stochastic. From the defender's perspective, the neighbouring matrix based on threshold defence mechanism is designed to exclude exogenous and large enough attacks. For cyber‐attacks whose amplitude lies in the measurement range, the dynamics is assumed to be an unknown nonlinear function of the states of the attacks and the vehicles. Based on such attack model, the neighbouring matrix and the control protocols of the vehicles, a state space model is first established for the CVSs. Then, an interaction network between the platoon layer in the original CVSs and the hidden layer in the virtual systems is constructed. By designing competitive interact matrices, stability of the overall system is ensured such that the state errors converge into a bounded range when the platoon layer suffers from cyber‐attacks. The results still hold for the worst case, for example, both the platoon layer and the hidden layer are attacked simultaneously. The effectiveness and superiority of the method are illustrated by simulations.
X-ray emission from a rapidly accreting narrow-line Seyfert 1 galaxy at z = 6.56
Authors: Wolf J. , Nandra K. , Salvato M. , Buchner J. , Onoue M. , Liu T. , Arcodia R. , Merloni A. , Ciroi S. , Di Mille F. , Burwitz V. , Brusa M. , Ishimoto R. , Kashikawa N. , Matsuoka Y. , Urrutia T. , Waddell S. G. H.
Published: November 2022

Context. The space density of X-ray-luminous, blindly selected active galactic nuclei (AGN) traces the population of rapidly accreting super-massive black holes through cosmic time. It is encoded in the X-ray luminosity function, whose bright end remains poorly constrained in the first billion years after the Big Bang as X-ray surveys have thus far lacked the required cosmological volume. With the eROSITA Final Equatorial-Depth Survey (eFEDS), the largest contiguous and homogeneous X-ray survey to date, X-ray AGN population studies can now be extended to new regions of the luminosity–redshift space (L2 − 10 keV >  1045 erg s−1 and z >  6).

Aims. The current study aims at identifying luminous quasars at z >  5.7 among X-ray-selected sources in the eFEDS field in order to place a lower limit on black hole accretion well into the epoch of re-ionisation. A secondary goal is the characterisation of the physical properties of these extreme coronal emitters at high redshifts.

Methods. Cross-matching eFEDS catalogue sources to optical counterparts from the DESI Legacy Imaging Surveys, we confirm the low significance detection with eROSITA of a previously known, optically faint z = 6.56 quasar from the Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs) survey. We obtained a pointed follow-up observation of the source with the Chandra X-ray telescope in order to confirm the low-significance eROSITA detection. Using new near-infrared spectroscopy, we derived the physical properties of the super-massive black hole. Finally, we used this detection to infer a lower limit on the black hole accretion density rate at z >  6.

Results. The Chandra observation confirms the eFEDS source as the most distant blind X-ray detection to date. The derived X-ray luminosity is high with respect to the rest-frame optical emission of the quasar. With a narrow MgII line, low derived black hole mass, and high Eddington ratio, as well as its steep photon index, the source shows properties that are similar to local narrow-line Seyfert 1 galaxies, which are thought to be powered by young super-massive black holes. In combination with a previous high-redshift quasar detection in the field, we show that quasars with L2 − 10 keV >  1045 erg s−1 dominate accretion onto super-massive black holes at z ∼ 6.
Observations of comet C/2020 F3 (NEOWISE) with IRAM telescopes
Authors: Biver N. , Boissier J. , Bockelée-Morvan D. , Crovisier J. , Cottin H. , Cordiner M. A. , Roth N. X. , Moreno R.
Published: November 2022

We present the results of millimetre-wave spectroscopic and continuum observations of the comet C/2020 F3 (NEOWISE) undertaken with the Institut de RadioAstronomie Millimétrique (IRAM) 30-m and the NOrthern Extended Millimeter Array (NOEMA) telescopes on 22, 25–27 July, and 7 August 2020. Production rates of HCN, HNC, CH3OH CS, H2CO, CH3CN, H2S, and CO were determined with upper limits on six other species. The comet shows abundances within the range observed for other comets. The CO abundance is low (3.2% relative to water), while H2S is relatively abundant (1.1% relative to water). The H2CO abundance shows a steep variation with heliocentric distance, possibly related to a distributed production from the dust or macro-molecular source. The CH3OH and H2S production rates show a slower decrease post-perihelion than water. There was no detection of the nucleus point source contribution based on the interferometric map of the continuum (implying a size of r < 4.7 km), but this yielded an estimate of the dust production rate, leading to a relatively low dust-to-gas ratio of 0.7 ± 0.3 on 22.4 July 2020.