bluuebunny/crossref_metadata_2025 huggingface dataset:
Hedonic Preferences to Audio and Visual Stimulation in Seniors with Cognitive Impairments
Authors: Felisberti Fatima M.
Published: August 2021

Background: Hedonic (or aesthetic) preferences to repeated sensory stimulation can remain stable over time (Island of Stability Effect, ISE) or vary with prior exposures (Mere Exposure Effect, MEE). Objective: Here we compared the liking ratings of seniors with cognitive impairments (mostly mild-to-moderate dementia, DPs) and neurotypical senior controls (CNs) to audio and visual stimuli and examined whether those ratings conformed to the ISE or the MEE predictions. Method: Participants (n = 212) rated sets of stimuli repeated three times at weekly intervals: images of Picasso’s paintings, PANTONE color cards, and avant-garde music clips. Results: The aggregated liking ratings of DPs and CNs were stable over time, in line with the ISE model. However, latent growth modeling indicated that those stable responses might have masked differences at the individual level, since seniors in both cohorts exhibited clusters of different responses over the time evaluated, supporting the predictions of the MEE. Notably, there was a dampening of hedonic experiences in DPs comparatively to CNs. Conclusion: The presence of hedonic responses (and individual variations) in DPs is relevant not only to their wellbeing and therapy interventions involving audio and visual stimulation, but also to the design of spaces that offset the downturn in hedonic experiences affecting seniors with cognitive impairments.
Ambulatory Blood Pressure Characteristics of Patients with Alzheimer’s Disease: A Multicenter Study from China
Authors: Wang Hualong , Xu Ying , Ren Rujing , Yao Feng , Chen Mei , Sheng Zhihua , Guo Xin , Li Yan , Chen Shengdi , Wang Gang
Published: August 2021

Background: Previous studies revealed that abnormal blood pressure (BP) plays an important role in the pathogenesis of Alzheimer’s disease (AD). However, little is known about the ambulatory BP characteristics of AD in the mild or severe stage. Objective: We explored the ambulatory BP characteristics of AD in the mild or severe stage. Methods: In the present study, 106 AD patients (42.5%male, average age 81.6 years) were enrolled from three centers in China. Clinal BP measurements at the supine and standing positions, neurological evaluations, and the 24 h ambulatory BP monitoring were performed. Results: In the 106 AD patients, 49.2%, 36.8%, and 70%of patients had 24 h, daytime, and nighttime systolic hypertension, respectively, while 19.8%, 29.2%, and 5.7%had 24 h, daytime, and nighttime diastolic hypotension. The prevalence of the reduced and reverse dipping pattern was 34.0%and 48.1%for systolic BP and 32.1%and 45.3%for diastolic BP, respectively. The daytime diastolic BP was significantly correlated with cognitive performance. After adjustment for age, sex, and body mass index, only daytime diastolic BP was associated with remarkable cognitive deterioration (p≤0.008). Further, AD patients in the severe stage had significantly lower levels of the 24 h, daytime, and nighttime diastolic BP, compared with those in the mild stage. Conclusion: In general, AD patients were featured with high nighttime systolic BP, low daytime diastolic BP, and abnormal circadian BP rhythm of reduced and reverse dipping. The diastolic BP, especially daytime diastolic BP, was adversely correlated with the cognitive deterioration in AD.
Heterogeneity and Factorial Structure in Alzheimer’s Disease: A Cognitive Perspective
Authors: Zangrossi Andrea , Montemurro Sonia , Altoè Gianmarco , Mondini Sara
Published: August 2021

Background: Alzheimer’s disease (AD) patients show heterogeneous cognitive profiles which suggest the existence of cognitive subgroups. A deeper comprehension of this heterogeneity could contribute to move toward a precision medicine perspective. Objective: In this study, we aimed 1) to investigate AD cognitive heterogeneity as a product of the combination of within- (factors) and between-patients (sub-phenotypes) components, and 2) to promote its assessment in clinical practice by defining a small set of critical tests for this purpose. Methods: We performed factor mixture analysis (FMA) on neurocognitive assessment results of N = 230 patients with a clinical diagnosis of AD. This technique allowed to investigate the structure of cognitive heterogeneity in this sample and to characterize the core features of cognitive sub-phenotypes. Subsequently, we performed a tests selection based on logistic regression to highlight the best tests to detect AD patients in our sample. Finally, the accuracy of the same tests in the discrimination of sub-phenotypes was evaluated. Results: FMA revealed a structure characterized by five latent factors and four groups, which were identifiable by means of a few cognitive tests and were mainly characterized by memory deficits with visuospatial difficulties (“Visuospatial AD”), typical AD cognitive pattern (“Typical AD”), less impaired memory (“Mild AD”), and language/praxis deficits with relatively spared memory (“Nonamnestic AD”). Conclusion: The structure of cognitive heterogeneity in our sample of AD patients, as studied by FMA, could be summarized by four sub-phenotypes with distinct cognitive characteristics easily identifiable in clinical practice. Clinical implications under the precision medicine framework are discussed.
A Cystatin C Cleavage ELISA Assay as a Quality Control Tool for Determining Sub-Optimal Storage Conditions of Cerebrospinal Fluid Samples in Alzheimer’s Disease Research
Authors: Mommaerts Kathleen , Willemse Eline A.J. , Marchese Monica , Larue Catherine , van der Flier Wiesje M. , Betsou Fay , Teunissen Charlotte E.
Published: August 2021

Background: An N-terminal octapeptide cleavage of the cystatin C protein was discovered by mass spectrometry when cerebrospinal fluid (CSF) was stored at –20°C for 3 months, which did not occur when CSF was stored at –80°C. Objective: The aim was to develop an immunoassay as quality assessment tool to detect this –20°C cleavage of cystatin C in CSF and support Alzheimer’s disease research. Methods: A specific monoclonal antibody and a double indirect sandwich ELISA were developed: one assay quantifies the octapeptide uncleaved protein specifically and the other quantifies the total cystatin C present in the biological fluid (both cleaved and uncleaved forms). The ratio of these concentrations was calculated to assess the extent of cleavage of cystatin C. The novel ELISA was validated and applied in a short-term (up to 4 weeks) and mid-term (up to one year) stability study of CSF stored at 4°C, –20°C, –80°C, and liquid nitrogen. Impact of freeze-thaw cycles, adsorption, and protease inhibitors were tested. Results: The ratio of truncated protein was modified following –20°C storage and seemed to reach a plateau after 6 months. The ratio was impacted neither by freeze-thaw cycles nor adsorption. The –20°C specific cleavage was found to be protease related. Conclusion: Using this novel double indirect sandwich ELISA, absolute levels of the total and uncleaved cystatin C and the ratio of truncated cystatin C can be measured. This assay is an easily applicable tool which can be used to confirm that CSF biospecimen are fit-for-purpose for Alzheimer’s disease research.
Torque for non-contact piezoelectric motor modulated by electromagnetic force
Authors: Wang Tingting , Xu Lizhong , Xing Jichun
Published: August 2021

In this paper, the structural design and driving mechanism of a non-contact piezoelectric motor modulated by electromagnetic force are introduced. The equations of the electromagnetic force and torque of the electromagnetic modulation mechanism for the motor are deduced. Based on the piezoelectric constitutive equation and torque balance equations of the driving system, the equation of the piezoelectric driving torque is also obtained. Using these equations, the influences of the related parameters on the relationship between electromagnetic torque and angle difference between pole and rotor are studied. The influences of the main parameters and signal frequency on piezoelectric driving torques are analyzed. Based on them, the torque optimization of the motor is completed and the load-carrying ability of the motor is increased by about 50 times. A prototype of the motor is developed. Its output torque is tested and compared with calculated one which illustrates the theoretical model here.
CHEMICAL FERTILIZATION THROUGH FERTIRRIGATION IN THE EVALUATION OF THE BIOCHEMICAL CHARACTERISTICS OF THE WATERMELON FRUITS
Authors: Santos de Andrade Antonio Ricardo , Franco Euler Soares , Guerra Hugo Orlando Carvallo , Jadoski Sidnei Osmar , Silva Edijailson Gonçalves da , Cruz Adiel Felipe da Silva , Ferreira Maria Emanuely da Silva , Silva Edes Torres da , Soares Hammady Ramalho e
Published: August 2021

The objective of this work was to evaluate the effects of splitting in three different doses of phosphorus and potassium, combined with each other, and it was applied fertirrigation in watermelon crop, and to evaluate their effects on fruit quality. The statistical was in a complete randomized block design, and the treatments were arranged in a factorial scheme (3 x 3) in subdivided splits, resulting in 9 treatments with tree replications, totaling 27 plots in the experimental area. In the horizontal plots the three doses of phosphorus fertilization (100, 150 and 300 kg.ha-1 of P2O5) were randomly allocated, and in the subplots the three potassium doses (50, 100 and 200 kg.ha-1 of K2O), were applied in fertirrigation. The cultivar used was Crimson Sweet. Seventy-Six days after planting (DAP) the biochemical characteristics of watermelon fruits were evaluated: total soluble solids (TSS), total treatable acidity (TTA) and potential of hydrogen (pH). According to the results, it was verified that only the chemical value of the TSS fruits, presented significant statistical differences between the studied doses because of the different source of fertilization K and P increased the soluble solid contents, the content of reducing sugars, and decreased pH. It was observed the different doses of K and P did not influence in the fruit quality parameters when it was analyzed separated: TTA and pH but the TTA values are according to consumer market standards. The best doses in order to economy of fertilizer were (150 kg ha-1 de P2O5 e 50 kg ha-1 of K2O).
2021–2022 Florida Citrus Production Guide: Postbloom Fruit Drop
Authors: Peres Natalia A. , Dewdney Megan M.
Published: August 2021

Reviewed April 2021. There are no changes in recommendation from 2020.
Chapter 14. Potato Production
Authors: Zotarelli Lincoln , Dittmar Peter J. , Roberts Pamela D. , Desaeger Johan , Wells Bonnie
Published: August 2021

Chapter 14 of the Vegetable Production Handbook.
Chapter 15. Root Crop Production in Florida
Authors: Beuzelin Julien , Dittmar Peter J. , Raid Richard N. , Smith Hugh A. , Wells Bonnie , Desaeger Johan , Zotarelli Lincoln , Zhang Shouan , Wang Qingren , Frey Craig
Published: August 2021

Chapter 15 of the Vegetable Production Handbook.
Chapter 5. Ethnic Vegetable Production
Authors: Liu Guodong , Wells Bonnie , Li Yuncong , Wang Qingren
Published: August 2021

Chapter 5 of the Vegetable Production Handbook.
CAFTA and U.S. Sugar
Authors: Schmitz Andrew , Schmitz Troy G. , Seale, Jr. James L.
Published: August 2021

The Central American Free Trade Agreement (CAFTA) is a trade agreement between the United States and Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, and the Dominican Republic. The agreement was put into law in 2005. Under the agreement the Dominican Republic will eliminate their sugar tariffs over a 15-year period. The United States will establish additional tariff rate quotas (TRQs) for the CAFTA countries beginning with an additional 107,000 metric tons in the first year. The quota amount increases to 151,140 metric tons by the end of the 15-year period. The United States is allowed to compensate exporters in an effort to limit sugar imports for stock management purposes. How large of an impact will CAFTA have on U.S. sugar producers? This document is FE578, one of a series of the Food and Resource Economics Department, UF/IFAS Extension. Original publication date January 2006.
Major By-Products of the Florida Citrus Processing Industry
Authors: Goodrich Renee M. , Braddock Robert  J.
Published: August 2021

This fact sheet, one in a series titled Florida Citrus Products and By-Products, provides an overview of the most common citrus by-products for commercial use. More detailed information on each major by-product can be found in the references listed, as well as in other titles of this series. This document is FSHN05-22, one of a series of the Food Science and Human Nutrition Department, UF/IFAS Extension. Original publication date October 2004. Revised February 2006.
2021–2022 Florida Citrus Production Guide: Canopy Management
Authors: Vashisth Tripti , Zekri Mongi , Alferez Fernando
Published: August 2021

There were no changes in recommendation from the 2020–2021 edition.
St. Augustinegrass for Florida Lawns
Authors: Trenholm Laurie E. , Schiavon Marco , Unruh J. Bryan , Shaddox Travis W. , Kenworthy Kevin E.
Published: August 2021

St. Augustinegrass (Stenotaphrum secundatum [Walt.] Kuntze) is widely adapted to the warm, humid (subtropical) regions of the world. It is believed to be native to the coastal regions of both the Gulf of Mexico and the Mediterranean. St. Augustinegrass is the most commonly used lawn grass in Florida (Figure 1). This publication is intended for homeowners and turfgrass managers that manage St. Augustinegrass in the state of Florida.

Previous version: Trenholm, Laurie, Bryan Unruh, and Travis Shaddox. 2017. “St. Augustinegrass for Florida Lawns”. EDIS 2017 (September). https://doi.org/10.32473/edis-lh010-2017.
Pesticide Toxicity Profile: Arsenical Herbicides
Authors: Fishel Frederick
Published: August 2021

This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of the arsenical herbicides registered for use in Florida.This document is PI-89, one of a series of the Pesticide Information Office, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Original publication date November, 2005.
Thielaviopsis Trunk Rot of Palm
Authors: Elliott Monica L.
Published: August 2021

Thielaviopsis paradoxa is a fungus that can infect any part of a palm, and so can cause numerous diseases. In Florida, the two most frequent (and usually lethal) Thielaviopsis diseases observed in the landscape and field nursery are a bud (heart) rot and trunk rot. Thielaviopsis bud rot is discussed at http://edis.ifas.ufl.edu/pp144. This document is PP-219, one of a series of the Plant Pathology Department, UF/IFAS Extension. Original publication date January 2006.
PP-219/PP143: Thielaviopsis Trunk Rot of Palm (ufl.edu)
Best Management Practices in the Everglades Agricultural Area: Fertilizer Application Control
Authors: Lang Timothy A. , Daroub Samira H. , Diaz Orlando A. , Chen Ming
Published: August 2021

This EDIS document is one in a series of publications that provide current implementation guidelines for commonly employed BMPs that target the reduction of P loads leaving EAA farms via drainage water. This document is SL-232, a fact sheet of the Soil and Water Science Department, UF/IFAS Extension. Original publication date January 2006.
INTRATHECAL 1% 2 CHLOROPROCAINE V/S 0.5% HYPERBARIC BUPIVACAINE IN AMBULATORY SURGERY
Authors: Choudhary Mukesh , Singh Abhimanyu
Published: August 2021

Background: Aims of the study to compare 2-CP with bupivacaine for spinal anesthesia in an elective ambulatory setting.

Methods: Hospital based Randomized, Double Blind, Interventional study conducted on patients undergoing for ambulatory surgery under subarachnoid block.

Results: The finding that shows the most significant advantage is the time for regression of the sensory block to S2, as 2-CP was faster than bupivacaine.

Conclusion: 2-chloroprocaine provides adequate duration and depth of surgical anesthesia for short procedures with the advantages of faster block resolution and earlier hospital discharge compared with spinal bupivacaine

Keywords: 2-chloroprocaine, Bupivacaine, Ambulatory surgery
COMPARISON OF INTRATHECAL BUPRENORPHINE VERSUS CLONIDINE AS AN ADJUVANT TO 0.5% HYPERBARIC BUPIVACAINE IN LOWER ABDOMINAL SURGERIES
Authors: Choudhary Mukesh , Singh Abhimanyu
Published: August 2021

Introduction: Present study was undertaken to compare the efficacy of intrathecal clonidine or buprenorphine with bupivacaine in lower abdominal surgeries.

Methods: 90 ASA I and II patients undergoing lower abdominal surgeries were randomly allocated into three groups(n=30). Group A received 3ml of 0.5% hyperbaric bupivacaine with 1ml normal saline, GroupB received 3ml of 0.5% hyperbaric bupivacaine with 60 mcg buprenorphine(1:5 dilution) and Group C received 3ml of 0.5% hyperbaric bupivacaine with 30mcg clonidine (1:5 dilution) respectively (Total volume 4ml). Onset time and duration of sensory and motor block, duration of analgesia, hemodynamics, VAS score, sedation score and side effect were compared.

Results: The duration of analgesia was significantly longest in GroupC (354.50±38.48min), followed by Group B (277.10±25.47min) and Group A(131.50±20.15min) (p<0.001)

Conclusion: Clonidine (30mcg) and buprenorphine (60mcg) when used as adjuvants to 0.5% hyperbaric bupivacaine intrathecally produces significantly longer duration and better quality of postoperative analgesia than bupivacaine alone.

Keywords: clonidine, buprenorphine, intrathecal, postoperative analgesia.
COVID-19 Pandemisinde Elektif Cerrahi Uygulanacak Hastaların Preoperatif Anksiyete Düzeylerinin Değerlendirilmesi
Authors: BALKAYA Ayşe Neslihan , KARACA Ümran , YILMAZ Canan , ATA Filiz
Published: August 2021

COVID-19 önlemleri alınarak elektif cerrahilerin yeniden başlatıldığı pandemi sürecinde elektif cerrahi uygulanacak hastaların preoperatif anksiyete düzeylerinin ve anksiyete seviyelerini etkileyen faktörlerin değerlendirilmesi amaçlandı. 18-75 yaş grubu elektif cerrahi uygulanacak 450 hasta dahil edildi. Yazılı onamları alınan hastalar preoperatif dönemde değerlendirildi. Demografik verileri, eğitim durumu, medikal geçmişi, anestezi ve cerrahi deneyimleri sorgulandı. COVID-19 hakkında soruların olduğu anket formu ile yirmişer maddelik durumluk ve sürekli kaygı ölçeklerinden oluşan Spielberger Durumluk-Sürekli Anksiyete Ölçeği (STAI) hastalar tarafından dolduruldu. Durumluk (STAI-I) ve sürekli (STAI-II) kaygı ölçeklerinde büyük puan yüksek anksiyete seviyesini, küçük puan ise düşük anksiyete seviyesini belirtir. 49.26±15.51 yaş ortalaması olan hastaların ortalama anksiyete düzeyi STAI-I’de 41.46±8.43, STAI-II’de 37.79±9.73 olarak bulundu. Opere edilen kliniklere göre hastaların STAI-I puanları orta düzeyde anksiyete, STAI-II puanları ise hafif düzeyde anksiyete ile uyumluydu. Hastaların yaşı ile STAI-I arasında negatif yönde korelasyon görüldü (r=-0.52, p=0.136), STAI-II’de ise yaş ile pozitif korelasyon saptandı (r=0.22, p=0.321). Cinsiyet, eğitim durumu, geçirilmiş ameliyat öyküsü ve anestezi deneyimi açısından değerlendirildiğinde preoperatif STAI-I ve II puanlarında farklılık saptanmadı. COVID-19 pandemisi hakkında yeterli bilgi sahibi olmadığını düşünen hastaların (%17,6) STAI-I ve STAI-II puanları anlamlı yüksekti (p= 0.000, p= 0.001). Ailesinde geçirilmiş COVID-19 enfeksiyonu bulunan hastaların STAI-I ve II puanları ile diğer hastaların puanları benzerdi (p=0.76, p=0.91). Hastane yatışında COVID-19 ile enfekte olma tedirginliği bulunan hastaların (287 hasta, %63.8) STAI-I puanı hastanede COVID-19’a yakalanmaktan korkmayanlara (163 hasta, %36.2) göre yüksek bulundu (p=0.05). Postoperatif dönemde hastane yatışı sırasında COVID-19 ile enfekte olan hasta olmadı. Elektif cerrahi geçirecek hastalarda COVID-19 pandemisinde preoperatif anksiyete düzeyleri artmıştır. Preoperatif dönemde hastalara COVID-19 ile ilgili rutin bilgilendirme yapılmasının ve alınacak önlemlerden bahsedilmesinin anksiyete düzeyini azaltmada faydalı olacağı düşüncesindeyiz
ОЦІНКА ТА МОДЕЛЮВАННЯ ЗАЛЕЖНОСТІ ПРЯМИХ ІНОЗЕМНИХ ІНВЕСТИЦІЇ ВІД МАКРОЕКОНОМІЧНИХ ЧИННИКІВ
Authors: Довгенко Яна
Published: August 2021

Стаття присвячена оцінці та аналізу динаміки капіталовкладень та моделюванню залежності прямих іноземних інвестицій від макроекономічних факторів. У статті проведено порівняльний аналіз тенденцій росту ВВП та капітальних вкладень. Проаналізовано динаміку валових інвестицій в основний капітал у порівнянні з розрахованими нормами. Побудовано кореляційне поле залежності ВВП від валових інвестицій. Встановлено взаємозв’язки між ПІІ та макроекономічними факторами. Проведено кореляційно-регресійний аналіз між факторними ознаками. З’ясовано наявність мультиколінеарності у вихідній базі даних факторних ознак. Побудовано методом головних компонент модель залежності динаміки ПІІ від ВВП та капітальних інвестицій в млн. доларів, середньої заробітної плати в доларах та валового зовнішнього боргу в млрд. доларів. Побудована модель визначає умови, залучення достатнього обсягу прямих іноземних інвестицій.
Personal Value Typology in the Moroccan Context: An examination of High School Students’ Orientations in Light of Gender and Ecology
Authors: Mamnoun Sanae , Nfissi Abdelhamid , Hougua Ben Ahmed
Published: August 2021

This study sought to examine the personal value types of high school students in Fez and its suburbs. It used a sample of 376 subjects and employed the Rokeach’s (1973) value survey instrument and the Musser and Orke (1992) typology to classify the personal values into types. The authors tested for differences by gender and geographical area. Findings revealed no gender differences in value type preferences since both male and female students were more alike than different in their value orientation by falling into the category of the Independent Maximizer. However, significant differences were noticed regarding the geographical area to which the respondents belong. Accordingly, the dominant value type of the sample was that of the Independent Maximizer represented by the students of Fez, followed by the Honorable Egoist exemplified by the students of Sefrou. The least frequent types were the Effective Crusader and the Virtuous Advocate under which the students of Tawjdate were classified. The authors discussed the findings with respect to anthropological and historical framework.
SENTIMENT ANALYSIS OF COVID-19 TWEETS
Authors: Nureni Azeez A. , Ogunlusi Victor E. , Uloko Emmanuel Junior
Published: August 2021

Sentiment analysis involves techniques used in analyzing texts in order to identify the sentiment and emotion dominant in such texts and classify them accordingly. Techniques involved include but not limited to preprocessing of texts and the use a machine learning or lexical based approach in classifying these texts. In this research, attempt was made to adopt a machine learning approach to classify tweets on Covid-19 which is considered a global pandemic. To achieve this noble objective, a cross-dataset approach was applied to train four machine learning classification algorithms: Support Vector Machine (SVM), Random Forest (RF) and Naïve Bayes (NB), as well as K-Nearest Neighbors algorithm (KNN). The final result will not only assist us in knowing the best performing algorithm, it will also assist in creating awareness on Covid-19 with the final objective of destigmatizing the patients through the analysis of sentiments and emotions on Covid-19  and finally use the same result for containing the spread of the pandemic
Serebral Palsi’li Çocuklarda Çiğneme Bozuklukları ve İlişkili Beslenme Problemleri
Authors: Özder Fatih , Serel Arslan Selen
Published: August 2021

Serebral palsi (SP) doğum öncesi, sırası veya sonrasında beyinde oluşan hasar sonucu meydana gelen klinik bir tablodur. Serebral palsi, çocukluk çağı engelliliğinin en yaygın nedenlerinden biridir. Serebral palside duyusal, motor ve zihinsel problemler tabloya eşlik etmektedir. Özellikle orofasiyal bölgedeki duyusal ve motor etkilenim beslenmenin önemli bir aşamasını oluşturan çiğneme fonksiyonunda ciddi problemlere yol açmaktadır. Çiğneme, besinleri parçalayıp yutmaya hazır hale getirilmesi sürecini ifade etmektedir. Çiğneme bozukluğu ise besinin ağıza alınması, ağızda tutulması ve yutulabilir bir kıvama getirilmesi sırasında görülen problemleri ifade etmektedir. Çiğneme fonksiyonu normal gelişim gösteren çocuklarda 4-6 ay civarında gözlenmeye başlamakta, dil hareketlerinin artması, dişlerin çıkması ve katı besin deneyimleriyle birlikte 8 yaşına kadar gelişim göstermektedir. Serebral palsili çocuklarda görülen oromotor disfonksiyonlar, anormal nörolojik gelişim, postüral bozukluklar ve kognitif etkilenim yaşa uygun besin dokularını yönetme ve besinleri yutulabilir kıvama getirme becerilerini olumsuz etkilemekte ve çiğneme bozukluğuna neden olmaktadır. Çiğneme bozukluğu nedeniyle SP’li çocuklarda katı besinlerin alımı sınırlanabilmekte ve daha çok yarı katı veya sıvı besinler gibi çiğneme becerisi gerektirmeyen besinler tercih edilmektedir. Bu durum gerekli enerji alımını sınırlandırabilmekte ve beslenme bozukluğuna neden olmaktadır. Aynı zamanda öğünlerin hazırlanması süreci de düşünüldüğünde hem çocuk, hem de aile için olumsuz sosyal etkileşim ve yaşam kalitesinde düşmeye neden olmaktadır. Bu nedenle çiğneme bozukluğu olan SP’li çocukların beslenme durumları erken dönemde belirlenmeli ve uygun tedavi yaklaşımları planlanmalıdır.
Serebral Palsi’li Çocuklarda Çiğneme Bozukluğunun Klinik ve Nütrisyonel Değerlendirmesi: Olgu Sunumu
Authors: Özder Fatih , Ilgaz Fatma , Serel Arslan Selen
Published: August 2021

Bu olgu sunumunun amacı; katı besin alamayan Serebral Palsi (SP)’li bir çocukta çiğneme ve nütrisyonel durum değerlendirme sonuçlarını sunmak ve tedaviye yönelik öneriler vermektir. Üç yaş on bir aylık kuadriplejik kız olgunun yaşa göre boy uzunluğu, yaşa göre vücut ağırlığı z-skoru-3.7 olduğu için ağır akut malnütrisyon olarak değerlendirilmiştir. Kaba Motor Fonksiyon Sınıflama Sistemi’ne göre seviye 5 düzeyinde olan olgunun Kaba Motor Fonksiyon Ölçütü A ve B alt bölümlerinden aldığı skor %23.9’dur. Bu sonuçlar olgunun fonksiyonel motor seviyesinin düşük olduğunu göstermiştir. Çiğneme performansı değerlendirmesinde; olgu Karaduman Çiğneme Performans Skalası’na göre seviye 4 (ısırma ve çiğneme yok)’tür. Çiğneme Fonksiyonu Gözlem ve Değerlendirme Aracı’ndan 13 puan almıştır. Her iki ölçekten elde edilen sonuç, olgunun şiddetli çiğneme bozukluğu olduğunu göstermektedir. Olgunun enerji ve besin ögesi alım miktarını belirlemek amacıyla 24-saatlik geriye dönük hatırlatma yöntemi ile besin tüketim kaydı alınmıştır. Olgunun diyeti ile günlük protein, vitamin ve mineral gereksinimlerinin çoğu karşılanabilirken, enerji, C vitamini ve posa gereksinimlerinin sırasıyla %78.6, %58 ve %15.8’inin karşılanabildiği saptanmıştır. Gereksinimlerinin tamamının ince sıvı ve ince püre içecek ve besinlerden karşılandığı, çiğneme gerektiren besinleri tüketmediği belirlenmiştir. Katı besin alamayan olguda enerji ihtiyacının önemli bir kısmı, protein ve vitamin-mineral ihtiyacının tamamı karşılanabilse de, ileri dönemde bu durum beslenme yetersizliğine yol açıp, hem çocuğun, hem de ailenin yaşam kalitesini olumsuz yönde etkileyebilir. Bu nedenle çiğneme bozukluğunun erken dönemde ele alınması ve gerekli müdahale programlarının oluşturulabilmesi için olguların fizyoterapist ve diyetisyen iş birliğinde değerlendirilmesi gerekmektedir.
THE EFFECTS OF PROBLEM BASED LEARNING WITH COOPERATIVE LEARNING ON PRESCHOOLERS’ SCIENTIFIC CREATIVITY
Authors: Siew Nyet Moi , Chin Mui Ken , Sombuling Agnis
Published: August 2021

This research aimed to determine the effects of Problem based learning (PBL) with cooperative learning (CL) and ‘Numbered Heads Together’ (NHT) on preschoolers’ five trait dimensions of scientific creativity: Fluency, Originality, Elaboration, Abstractness of title, and Resistance to premature closure. A quasi-experimental pre-test and post-test control group design was employed in the research. The sample consisted of 216 six-year-old preschoolers from three randomly selected preschools and assigned to PBL-CL‘NHT’ (n=72), PBL (n=72), and hands-on (TG) (n=72) instructional methods. The Figural Scientific Creativity Test was used as the pre-test (Form A) and post-test (Form B). Multivariate Analysis of Covariance (MANCOVA) was conducted on the post-test scores with pre-test scores as the covariates to determine whether a significant difference existed across the three methods. The results indicated that preschoolers taught in the PBL-CL‘NHT’ method significantly outperformed their peers in the PBL method who, in turn, significantly outperformed their peers in the TG method in Fluency, Originality, Elaboration, Abstractness of title, and Resistance to premature closure. Large effect sizes were obtained for comparing PBL-CL ‘NHT’ with PBL and TG method. The findings suggest that the PBL-CL ‘NHT’ method has a significant positive impact on fostering preschoolers’ five trait dimensions of scientific creativity. Key words: cooperative learning, preschoolers, problem based learning, scientific creativity, trait dimensions.
BIOLOGY TEACHING THROUGH SELF-REGULATED LEARNING AND COGNITIVE STRUCTURE: AN ANALYSIS OF THE EFFECT OF LEARNING STRATEGIES FOR COGNITIVE DEVELOPMENT VIA LATENT GROWTH MODEL
Authors: Tasci Guntay , Yurdugul Halil
Published: August 2021

This research applied the learning strategies to predict in an effect longitudinal growth of cognitive structure of students in biology. The aim of the research is to assess the effect of activating learning strategies on cognitive structures regarding biology. The research was conducted by using control group design. The sample of research was composed of 60 prospective teachers randomly assigned to the experimental and the control groups. The longitudinal data were collected every 2 weeks and 4 times in total considering the concept maps. The data were quantitatively analysed in terms of the number of concepts, connections and central concepts. Latent growth modelling (LGM) was used to analyse change in cognitive structure over time. The findings suggested that the experimental group did better in cognitive structure than the control group in terms of forming connections and central concepts. Accordingly, teaching students self-regulated learning strategies and providing support in the written material to activate the strategies influence the development of cognitive structure in a positive way in terms of the extent and the integration. Therefore, activation of the use of self-regulated learning strategies in the teaching are thought to contribute to the learning of biology.
Key words: biology education, cognitive structure, self-regulated learning, latent growth modelling.
THE EFFECT OF THE COMMON KNOWLEDGE CONSTRUCTION MODEL-ORIENTED EDUCATION ON SIXTH GRADE STUDENTS’ VIEWS ON THE NATURE OF SCIENCE
Authors: Bakırcı Hasan , Çalık Muammer , Çepni Salih
Published: August 2021

The aim of the present research was to explore the effect of the Common Knowledge Construction Model (CKCM)-oriented education on sixth grade students' views on the Nature of Science (NOS) and to compare it with the existing learning model (5Es learning model). The research was conducted with a total of 76 students (38 by 38--for experimental and control groups) in 2013-2014 school year. Within a quasi-experimental research design, the Views of Nature of Science Questionnaire (VNOS) and the Student Interview on the Nature of Science Aspects (SINOSA) were used for data collection. Quantitative data from the VNOS were exposed to independent t-test while qualitative data from the interview protocol were analyzed using content analysis. Results of pre-test and pre-interview denoted that both groups properly constructed ‘empirical’ aspect of the NOS while the other aspects of the NOS were naïve and transitional levels. After the intervention, it was found that the control group’s views of the NOS, except for the empirical aspect, were transitional level whilst those of the experimental group were informed level. Further, it was elicited that the experimental group performed the highest change in ‘imaginary and creative’ aspect of the NOS.
Key words: CKCM, 5Es learning model, light and sound topic, nature of science, science education.
AN EXAMINATION OF THE CORRELATION BETWEEN SCIENCE AND TECHNOLOGY ATTITUDES SCALE, FREQUENCY OF SMARTPHONE USAGE SCALE AND LIFELONG LEARNING SCALE SCORES USING THE STRUCTURAL EQUATION MODEL
Authors: Kör Hakan , Erbay Hasan , Engin Melih , Dünder Emre
Published: August 2021

Lifelong learning can be defined as all of the activities which aim to develop an individual’s skills, knowledge and abilities, socially, individually and professionally. Previous research on lifelong learning has been about using computers, digital competence and the correlation between demographic characteristics and intelligence. However, only one scale was used in this research, and, in general, only scores for demographic characteristics and lifelong learning were compared. In this research, the correlation between distance-learning students’ attitudes to technology, their frequency of use of smartphones and their attitudes to lifelong learning were examined. Reliability studies were carried out prior to the study and the Turkish adaptations of the scales published in international journals were administered with permission. The study sample consisted of 881 students studying in 12 different units of Hitit University: six Vocational Schools, four Faculties and two Graduate Schools. The data were analysed by creating a structural equation model on the open source R analysis program. According to the research results, there was a significant correlation between the three scales, and the correlation between the ‘lifelong learning’ scores and the ‘frequency of of smartphone usage’ scores was greater than the ‘technology attitudes’ scores.
Key words: lifelong learning, technology attitudes, smartphone usage, technology leadership.
Automatización de procesos industriales mediante Industria 4.0
Authors: Barona López Gustavo , Velasteguí Luis Efraín
Published: August 2021

El articulo tiene por objetivo presentar la automatización de procesos industriales mediante Industria 4.0, para establecer los niveles jerárquicos de automatización a partir de la pirámide de automatización. Para esto, se estructuró una teoría acerca de Industria 4.0 con relación a la pirámide de automatización. Posteriormente se presenta la automatización de procesos industriales relacionados a envasado de bebidas, medición de flujo, tecnología de red Wireless, integración total de niveles y refinación de petróleo, en cada uno se muestra su arquitectura de automatización para realizar la evaluación de sus niveles en referencia al concepto de pirámide de automatización. En la evaluación se describieron los instrumentos de campo, control y sistema SCADA, en relación a la pirámide de automatización. Se concluye que la red de comunicación Ethernet industrial por su alta capacidad de transmitir datos entre los niveles de empresa, cableado de gran extensión, facilidad de comunicación entre controladores e ideal para redes de área local (LAN), es utilizada en el Nivel 2, Nivel 3 y Nivel 4, mientras que las redes de comunicación PROFIBUS, PROFINET, HART, IO-Link y AS-Interface, por su transferencia de datos en tiempo real entre instrumentos de campo y controladores, trabajo en ambientes explosivos, manejo de tráfico de datos, recuperación de datos en la red, entre otras, es utilizada en el Nivel 0 y Nivel 1 en la automatización de procesos industriales.
Case Report of Brown McLean Syndrome
Authors: Lee Dongyoung , Han Gyu Le , Lim Dong Hui , Chung Tae Young
Published: August 2021

Purpose: To report two rare cases of Brown McLean syndrome after cataract surgery in a patient with aphakia.Case summary: (Case 1) A 54-year-old woman with Marfan’s syndrome who had aphakia and peripheral corneal edema after left eye cataract surgery 4 years ago. The patient had an elevated lesion in the peripheral cornea without involving the central cornea, and had symptoms of pain, irritation and tearing. Specular microscopy showed normal endothelial cell density and morphology in the edematous cornea. The peripheral corneal edema improved after use of antibiotics, autoserum eyedrops and 5% NaCl eyedrops. (Case 2) A 61-year-old woman with aphakia in her left eye after bilateral cataract surgery 11 years ago, underwent surgery for a macular hole in both eyes. The patient developed peripheral corneal erosions and edema in the left eye 2 months after the surgery. Specular microscopy showed normal endothelial cell density and morphology. The peripheral corneal edema was static over the years while using 5% NaCl eyedrops and artificial tears, and did not progress to involve the central cornea.Conclusions: Brown McLean syndrome is a rare disease but the possibility should be considered if a patient with aphakia after cataract surgery has peripheral corneal edema for several years.
Three Cases of Intraoperative Acute Fluid Misdirection Syndrome during Cataract Surgery
Authors: Park Hyun Young , Kim Ji Hyun
Published: August 2021

Purpose: We report the management of three cases of intraoperative acute fluid misdirection syndrome during cataract surgery.Case summary: Cataract surgery was performed in one eye of an 82-year-old woman with pseudoexfoliation syndrome, one eye of an 80-year-old man with end-stage glaucoma, and both eyes of a 72-year-old man with pseudoexfoliation syndrome. In the first two cases, the capsular bag space decreased during cortex aspiration and after removal of the cortex, respectively. After intravenous mannitol and intake of oral acetazolamide, the intraocular lens was successfully inserted in the first two cases on the same day. In the third case, after first removing the nucleus and cortex of the right eye, the capsular bag space decreased and an intraocular lens was carefully inserted. No intraoperative complications were seen during the left eye operation. One month after the operation, the best-corrected visual acuity had improved and the intraocular pressure was within normal limits for all three cases.Conclusions: A relatively shallow chamber, pseudoexfoliation, zonular laxity, and use of high molecular weight ophthalmic viscosurgical devices may cause acute fluid misdirection syndrome during cataract surgery. Pars plana vitrectomy may be required. However, intravenous high osmotic agent treatment should be attempted first, followed by intraocular lens insertion on the same day.
XIX. YÜZYIL MISIR’INDA YAYINLANMIŞ ARAPÇA BİR MAKTELDE MÜCEDDİDÎ HÂLİDÎ YORUMUN MUHTEMEL ETKİLERİ ÜZERİNE: NÛRU’L-‘AYN FÎ MEŞHEDİ’L HÜSEYN’İN YAZIM SÜRECİNE DAİR BAZI MÜLAHAZALAR
Authors: AZİZOVA Elnura
Published: August 2021

On dört asırlık İslam tarihinde çok az olay 10 Muharrem 61 (10 Ekim 680) yılında vukû bulmuş Kerbelâ Vak‘ası kadar dinî-siyasî etkileri açısından tartışılmıştır. Tarihi süreç içerisinde Kerbelâ olayı Müslüman halkların edebiyatında başlı başına bir tür olarak “Maktelü’l-Hüseyn”lerin oluşmasına sebep olmuştur. Sosyo-kültürel tarih açısından yeterli incelemeye tâbî tutulmamış Arapça maktellerden biri Şâfiî-Eş‘arî alimi Ebû İshâk el-İsferâyinî’ye (ö. 418/1027) ait olduğu ileri sürülen Nûru’l-‘ayn fî meşhedi’l-Hüseyn’dir. Bu makalede doküman analizi metodu kullanılarak Nûru’l-‘ayn’ın literatüre geçtiği dönem tespit edilecek, aynı zamanda mevcut yazma ve matbû nüshalarının tarihlerinden hareketle yazıldığı süreç ortaya konmaya çalışılacaktır. Ardından karşılaştırmalı yöntem kullanılarak Arapça makteller içinde kendine özgü yönlerinden hareketle eserin yazıldığı dinî ve kültürel çevreyle ilgili varsayımlarda bulunulacaktır.
Glucose administration downregulates lipoprotein lipase activity in vivo: a study using repeated intravenous fat tolerance test
Authors: Jindřichová E , Kratochvílová S , Kovář J
Published: August 2021

Lipoprotein lipase (LPL) is a key factor determining the clearance of triglycerides from the circulation. The enzyme activity is tissue-specifically regulated by insulin, but it is not clear yet how insulin regulates the total LPL activity in the circulation. To answer such question, we measured LPL activity using the intravenous fat tolerance test (IVFTT) that was carried out 1 h before as well as 2 h and 4 h after oral administration of glucose (75 g) in eleven healthy male volunteers. In control experiments, no glucose was given to the subjects. Glucose administration resulted in an expected increase in plasma glucose and insulin and in a suppression of non-esterified fatty acid concentration. The LPL activity assessed in IVFTT as a k(2) rate constant did not change in control experiments and decreased to 78 % and 73 % of baseline values 2 h and 4 h after glucose administration, respectively (p=0.01). Similarly, LPL activity measured in the plasma after intravenous injection of heparin at the end of the experiments was 16 % lower (p<0.05) after glucose administration. In conclusion, LPL activity is already downregulated in vivo 2 h after glucose administration. The results of our study indicate that repeated IVFTT is a promising approach for studying acute changes in LPL activity.
INISIASI GERAKAN PEDULI LINGKUNGAN PADA MASYARAKAT KELURAHAN BUKIT SARI PANGKALPINANG
Authors: Febriani Luna
Published: August 2021

Environment and disaster are an integral and inseparable part. In other words, environment can influence a disaster incidence in an area. Environmental issues and disasters are also urgent in Indonesian society. Apart from territorial location and demographic problems, damage and indifference to environment often present such disasters as floods, landslides, earthquakes, abrasion and so on. Flood is one of the environmental problems often occurring in Kelurahan Bukit Sari (Bukit Sari Village). This is due to the geographical conditions of Bukit Sari, located on a fairly low plain at several points and the lack of public awareness of environmental concerns. To minimize this environmental problem, the people of Kelurahan Bukit Sari have taken some efforts and movements to take care of the environment. This research is aimed at studying the environmental movements carried out by the community in order to preserve the environment. The results showed that the environmental care community movement is an initiative carried out by the community itself, while the environmental care movement consists of: waste management and sales, urban framing program and weekly mutual help or cooperative movement.
REVITALISASI PRANATA SOSIAL DAN REKONSTRUKSI PENYELENGGARAAN MUSRENBANG
Authors: Peribadi Peribadi , Tawulo Megawati Asrul
Published: August 2021

The study aims to develop a strategic formulation by means of integrating and synthesizing traditional typical planning pattern called Meobu-Obu and  Musrenbang (Community consultation on development planning held annually from village level to national level) as participatory development planning  occurring so far in the area of South Konawe Regency Government. The attempts of reconstructing and functionalizing rural social institutions were developed through community studies, participatory studies and eclectic case studies. The results show that the process of utilizing Village Funds (VF) still focuses more on physical development aspect rather than the aspect of community socio-economic empowerment. Meanwhile, the process of organizing the Musrenbang tends to be formalistic to merely abort the procedural aspects. Similarly, the institution of kalosara still wrestles with ritualistic field of un sich continuosly, so that the sacralization of kalosara culture has not entered the developmental field yet. It is exactly in this context that the result of research offers a formulation of Musrenbang based on cultural value of kalosara to be used in the future in the attempt of building the rural areas, particularly in the mainland of Southeast Sulawesi Province.
Identification of Key mRNAs as Prediction Models for Early Metastasis of Pancreatic Cancer Based on LASSO
Authors: Xue Ke , Zheng Huilin , Qian Xiaowen , Chen Zheng , Gu Yangjun , Hu Zhenhua , Zhang Lei , Wan Jian
Published: August 2021

Pancreatic cancer is a highly malignant and metastatic tumor of the digestive system. Even after surgical removal of the tumor, most patients are still at risk of metastasis. Therefore, screening for metastatic biomarkers can identify precise therapeutic intervention targets. In this study, we analyzed 96 pancreatic cancer samples from The Cancer Genome Atlas (TCGA) without metastasis or with metastasis after R0 resection. We also retrieved data from metastatic pancreatic cancer cell lines from Gene Expression Omnibus (GEO), as well as collected sequencing data from our own cell lines, BxPC-3 and BxPC-3-M8. Finally, we analyzed the expression of metastasis-related genes in different datasets by the Limma and edgeR packages in R software, and enrichment analysis of differential gene expression was used to gain insight into the mechanism of pancreatic cancer metastasis. Our analysis identified six genes as risk factors for predicting metastatic status by LASSO regression, including zinc finger BED-Type Containing 2 (ZBED2), S100 calcium-binding protein A2 (S100A2), Jagged canonical Notch ligand 1 (JAG1), laminin subunit gamma 2 (LAMC2), transglutaminase 2 (TGM2), and the transcription factor hepatic leukemia factor (HLF). We used these six EMT-related genes to construct a risk-scoring model. The receiver operating characteristic (ROC) curve showed that the risk score could better predict the risk of metastasis. Univariate and multivariate Cox regression analyses revealed that the risk score was also an important predictor of pancreatic cancer. In conclusion, 6-mRNA expression is a potentially valuable method for predicting pancreatic cancer metastasis, assessing clinical outcomes, and facilitating future personalized treatment for patients with ductal adenocarcinoma of the pancreas (PDAC).
Coiled-Coil Based Inclusion Bodies and Their Potential Applications
Authors: Gil-Garcia Marcos , Ventura Salvador
Published: August 2021

The production of recombinant proteins using microbial cell factories is frequently associated with the formation of inclusion bodies (IBs). These proteinaceous entities can be sometimes a reservoir of stable and active protein, might display good biocompatibility, and are produced efficiently and cost-effectively. Thus, these submicrometric particles are increasingly exploited as functional biomaterials for biotechnological and biomedical purposes. The fusion of aggregation-prone sequences to the target protein is a successful strategy to sequester soluble recombinant polypeptides into IBs. Traditionally, the use of these IB-tags results in the formation of amyloid-like scaffolds where the protein of interest is trapped. This amyloid conformation might compromise the protein’s activity and be potentially cytotoxic. One promising alternative to overcome these limitations exploits the coiled-coil fold, composed of two or more α-helices and widely used by nature to create supramolecular assemblies. In this review, we summarize the state-of-the-art of functional IBs technology, focusing on the coiled-coil-assembly strategy, describing its advantages and applications, delving into future developments and necessary improvements in the field.