bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Antibacterial Effectiveness of Orange Peel Extracts from Five Varieties Against Strain of Multi Drug Resistance Escherichia coli
Authors: Pradita Diding , . Yuandani , Wira Septama Abdi
Published: June 2024

The purpose of this study was to investigate the antibacterial activity of orange peel extracts from five different orange varieties in North Sumatera against resistant Escherichia coli bacteria and compare it to the effectiveness of vancomycin and erythromycin. To assess antibacterial activity, orange peel extracts were prepared from five different orange varieties, namely Citrus aurantifolia, Citrus microcarpa Bunge, Citrus limon L., Citrus sinensis L., and Citrus hystrix. Antibacterial activities were evaluated using the microdilution method to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The best antibacterial activity was determined using the smallest MIC and MBC values. The research found that all five orange peel extracts exhibited significant antibacterial activity compared to the standard antibiotics vancomycin and erythromycin. The most potent inhibitory effect was observed with the Citrus hystrix peel extract, with the lowest MIC and MBC (125 and 250 µg/mL), followed by Citrus aurantifolia (250 and 500 µg/mL), and Citrus sinensis L. (500 and 500 µg/mL). The results showed significant antibacterial activity of orange peel extracts from five different orange varieties in North Sumatera against resistant Escherichia coli bacteria.

Keywords: Antibiotic resistance, citrus peel extracts, Escherichia coli, MIC, MBC.
Assessment of mobility and related factors among older patients with osteoporosis
Authors: Luc Tran Viet , Huong Nguyen Thi Thu , Anh Nguyen Trung
Published: June 2024

This cross-sectional study was conducted to assess mobility and related factors among older people with osteoporosis treated at the National Geriatric Hospital. Mobility was assessed using the Time Up and Go test (TUG test). The proportion of participants with mobility impairment was 22.0%. The mean time of the TUG test was 12.3 ± 3.9 (seconds). There were significant associations between impaired mobility and age ≥ 80 years old with OR=3.3, knee osteoarthritis with OR=3.5, and diabetes with OR=3.0. There were significant associations between impaired mobility and geriatric syndromes: frailty syndromes (OR=3.5), low levels of physical activity (OR=3.5), and high risk of falls (OR=3.0). In conclusion: one in five older osteoporosis patients has impaired mobility. Our results highlighted that advanced age, knee osteoarthritis, diabetes, and geriatric syndromes such as frailty, low physical activity level, and high risk of falls were significantly associated with mobility in older patients with osteoporosis.
Early diagnostis of splenic ectopic pregnancy: A case report and review literature
Authors: Duc Pham Hong , Khuyen Pham Huu
Published: June 2024

Splenic ectopic pregnancy is extremely rare but carries a high risk of life-threatening intraperitoneal bleeding. Here, we present a 40-year-old woman presenting with vaginal bleeding. Although the intrauterine device (IUD) had been in place for 6 years, urinary and serum tests were positive for pregnancy. However, transvaginal ultrasound showed an empty uterus, no apparent adnexal masses or free fluid. An abdominal ultrasound was subsequently performed, which revealed a viable gestational sac in the spleen. An MRI that did not induce ionizing radiation was also performed, confirming the diagnosis of this splenic pregnancy. The gastrointestinal surgeon completed a laparotomy which successfully removed the spleen's superior pole containing an ectopic pregnancy.
Factors related to risk of falls among older post-stroke patients
Authors: Luc Tran Viet , Anh Nguyen Trung , Huong Nguyen Thi Thu
Published: June 2024

This study was conducted to identify factors related to fall risk among older post-stroke patients. A cross-sectional study was conducted on 107 post-stroke patients aged ≥ 60 years old treated at the National Geriatric Hospital. Fall risk was assessed using the 21-item Fall Risk Index. The percentage of participants with a high risk of falling was 69.2%. There were significant differences between the high risk of falls and the levels of disability, depression, and instrumental activities of daily living. The multivariate logistic regression model showed that mild to severe disability after stroke (OR=4.005) and patients with impairment of instrumental activities of daily living (OR=3.844) were significantly associated with an increased risk of falls in elderly post-stroke patients. This study showed two in three participants have a high risk of falls. Disability levels, instrumental activities of daily living, and depression were associated with a high risk of falls.
Clinical outcomes and risk factors for mortality in diabetic patients with staphylococcus aureus pneumonia: A case-control study
Authors: Thu Vo Pham Minh , Quyen Nguyen Thuy , Dang Tran Cong , Bao Nguyen The
Published: June 2024

The study was conducted to investigate the clinical outcomes and mortality risk factors related to Staphylococcus aureus pneumonia in patients with and without diabetes mellitus (DM). This was a case-control study on 118 patients with S. aureus pneumonia hospitalized between April 2021 and May 2023. The results reveal that diabetic female patients were prone to acquire Staphylococcus aureus pneumonia than non DM group (66.7% vs. 36.6%, p = 0.003); DM patients have more comorbidities (4.64 ± 2.07 vs. 3.46 ± 1.85; p = 0.003) compared to non-DM patients. Clinical outcomes, including 30-day all-cause mortality and pneumonia-related complications, showed no significant difference between patients with and without DM (all p > 0.05). Two independent risk factors for mortality in DM patients with S. aureus pneumonia are age > 65 (OR = 0.09, 95%CI: 0.01-0.64, p = 0.017) and central nervous system disease (OR = 18.54, 95%CI: 1.81-190.07, p = 0.014). The relatively high mortality rate in DM patients, predominantly attributed to MRSA infection, underscores the importance of staying focus on the diagnosis and adopting an appropriate initial antibiotic treatment approach. It is crucial to particularly note individuals with multiple comorbidities, especially those with central nervous system diseases.
Clinical, subclinical characteristics and treatment outcomes of patients with community - acquired pneumonia at risk of pes infection
Authors: Thanh Dang Duy , Thuy Cao Thi My , Tran Nguyen Thi Hong , Hao Truong Thi Nhu , Khoa Vo Nhat , Hien Nguyen Vu , Bao Nguyen The
Published: June 2024

This study aims to describe the clinical and subclinical characteristics and evaluate treatment outcomes of community-acquired pneumonia (CAP) patients at risk of Pseudomonas aeruginosa, extended-spectrum beta-lactamases-producing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus (PES) infection. A cross-sectional descriptive study was conducted on 90 CAP patients with potential PES infection admitted to the Respiratory Department of Can Tho Central General Hospital in 2023. Most cases presented with symptoms, including moist rales (91.1%), increased cough (90%), dyspnea (86%), purulent sputum production (77.8%), and consolidation syndrome (71.1%). More than half of the cases exhibited fever (54.4%). A white blood cell count increase was typical (13.31 x 109 cells/L) and predominantly neutrophilic (81.3 ± 19.7%). Chest radiography predominantly showed bilateral infiltration (58.9%). PES pathogens were isolated in 30 patients (33.3%). The majority of cases did not respond to initial antibiotics (56.6%), most of the cases were stable and cured (accounting for 91.1%) with an average hospital stay of 8 days. Patients with CAP at risk of PES infection exhibit typical acute symptoms and laboratory features of conventional CAP. Most responded poorly to initial treatment, but the final treatment resulted in a very high rate of stability and cure.
Evaluation of acute and subchronic toxicity of “Huyet Phu Truc U Hoan” in experimental animals
Authors: Thai Dang Cong , Nam Trinh Hoai , Hien Nguyen Minh , Hien Dang Thi Thu
Published: June 2024

This research was carried out to evaluate the acute and sub-chronic toxicity of ‘‘Huyet phu truc u hoan’’ (HPTUH) in experimental animals. The acute toxicity was defined on Swiss mice by the Litchfield – Wilcoxon’s method and the sub-chronic toxicity on Wistar rat’s hematopoietic function, liver, and kidney functions according to the World Health Organization Guidance. As a result, with doses from 10g/kg to 50g/kg, LD50 of HPTUH was not determined. With the doses from 2.38g/kg to 7.14g/kg per day on Wistar rat for 8 consecutive weeks, haematological parameters, ALT, AST, urea and creatinine levels were unaffected. In addition, the HPTUH did not produce any toxic effect in the animals’s liver and kidney in the treated animals compared to the control.
Adverse Childhood Experience among Adolescents in the Ethnic Minorities of Lang Son Province
Authors: Vinh Ngo Anh , Hoan Nguyen Thi Mai
Published: June 2024

The objective of this paper was to investigate the prevalence of adverse childhood experiences (ACEs) and associated factors among adolescents of the ethnic minorities of Lang Son province. This cross-sectional research was carried out in Lang Son province. A total of 845 students in boarding schools participated in the study. Adverse Childhood Experiences Questionnaire (ACE-Q) was used to measure ACEs. Multivariate Logistic Regression was performed to identify associated factors with ACEs. Emotional abuse is the most common ACE, experienced by 21.9% of the participants, followed by emotional neglect at 14.4% and parental divorce at 11%. Overall, 48.7% experienced ACEs in their lifetime. The frequency of parental visits every two months significantly increases the likelihood of adverse experiences (OR = 2.41, 95% CI: 1.43-4.05, p-value = 0.0009), and living in households with fewer than ten people versus ten or more significantly decreases the risk (OR = 0.48, 95% CI: 0.33-0.70, p-value < 0.0001). Additionally, internet use for 4 hours/day (OR = 0.24, 95% CI: 0.15-0.38, p-value < 0.01), 5 hours/day (OR = 0.26, 95% CI: 0.13-0.51, p-value < 0.01), and six or more hours/day (OR = 0.21, 95% CI: 0.11-0.43, p-value < 0.01) are also significantly associated with lower odds of adverse experiences, suggesting protective effects of extended daily internet use against adverse childhood experiences. This study underscores a significant prevalence of ACEs among adolescents in ethnic minority communities in Lang Son province, pointing to an urgent need for comprehensive strategies to address these challenges.
Infecção de sítio cirúrgico em pacientes submetidos a artroplastias de quadril e joelho
Authors: Batista Josemar , de Souza Jessica Tainah Jiuliete de Araújo Ferreira Gomes , Pondelek Gislayne Cristine Pivatto , Da Silva Danieli Parreira , Cruz Elaine Drehmer de Almeida
Published: June 2024

Objetivo: Caracterizar os casos de Infecções de Sítio Cirúrgico (ISC) em pacientes submetidos a artroplastias de quadril e joelho. Método: Pesquisa transversal, retrospectiva e quantitativa realizada em um hospital público, de ensino e de alta complexidade da região sul do Brasil. A coleta de dados ocorreu entre 2020 e 2022 em registros contidos em 91 prontuários e fichas pós alta hospitalar no período de até 90 dias após a cirurgia destinada ao implante da prótese. Os dados foram analisados por estatística descritiva e taxa de incidência de ISC. Resultados: Foram analisados 49 (53,8%) registros de artroplastia de joelho e 42 (46,2%) de quadril. Cinco casos evoluíram com infecção, todos detectados no retorno ambulatorial pós artroplastia de joelho, resultando em taxa de incidência de ISC em artroplastias de 5,5% (n=5). As infecções foram caracterizadas como incisional profunda (40%; n=2), de órgão ou cavidade (40%; n=2) e superficial (20%; n=1); decorrendo em reinternação em 80% dos casos e correspondente tempo médio de hospitalização de 11 dias (DP=4,2). Conclusão: O expressivo índice de ISC em cirurgias limpas direciona para a necessidade de intensificar boas práticas cirúrgicas. Reitera-se a vigilância ambulatorial como estratégia para a construção realística de indicadores e subsídio para a prevenção.
Pemerataan Pendidikan melalui Implementasi Kebijakan Sistem Zonasi di Sekolah SMAN 1 Hu’u dan SMK Negeri 1 Hu’u Kabupaten Dompu
Authors: Hajar Qurban , Nursidrati Nursidrati , Firmasyah Edi , Baharudin Baharudin , Awaluddin Rizka
Published: June 2024

Tujuan dari dilakukannya penelitian ini untuk mengetahui bagaimana penerapan atau implementasi dari kebijakan sistem zonasi PPDB yang menjadi salah satu upaya dalam pemerataan pendidikan pada sekolah menengah atas di wilayah kecamatan Hu’u kabupaten Dompu. Metode penelitian yang digunakan yaitu penelitian kualitatif deskriptif. Penelitian ini dilakukan di SMA Negeri 1 Hu’u dan SMK Negeri 1 Hu’u. Untuk memperoleh data yang diinginkan, peneliti melakukan observasi, wawancara dan studi dokumentasi. Dalam menganalisis data yang telah diperoleh, peneliti menggunakan model Miles dan Huberman yaitu mereduksi data, menyajikan data dan melakukan penarikan kesimpulan dengan triangulasi sumber dan triangulasi teknik sebagai uji keabsahan data. Hasil penelitian yang diperoleh adalah : 1) terpenuhinya enam variabel Van Meter dan Van Horn dalam implementasi kebijakan sistem zonasi yaitu sebagai berikut : a) Aturan Kepala Disdikpora tentang Juknis Pelaksanaan PPDB SMA/SMK Negeri menjadi standar dan tujuan dari  implementasi kebijakan sistem zonasi PPDB SMA/SMK negeri. Namun, kebanyakan masyarakat ataupun wali murid kurang memahami isi peraturan tersebut. b) segala hal yang diperlukan dalam implementasi kebijakan ini sudah terpenuhi atau tercukupi melalui adanya panitia PPDB yaitu guru, karyawan dan OSIS, serta sarana prasarana yang mendukung; c) komunikasi antar pelaksana sistem zonasi PPDB di SMA Negeri 1 Hu’u dan SMK Negeri 1 Hu’u serta Disdikpora berjalan dengan lancar melalui adanyaa sosialisasi baik secara langsung maupun melalui grup whatsapp ataupun grup line; d) Dalam pengimplementasian sistem zonasi tidak semua berdasarkan zona daerah siswa, melainkan perengkingan dari hasil nilai UNBK; e) perlunya perbaikan dalam sistem zonasi; dan f) kondisi ekonomi di lingkungan SMA Negeri 1 Hu’u dan SMK Negeri 1 Hu’u rata-rata petani. 2) Dampak positif dari implementasi kebijakan sistem zonasi di SMA N 1 Hu’u dan SMK N 1 Hu’u yaitu input peserta didik pada sekolah tersebut merata dan meningkatnya motivasi belajar di sekolah favorit, sedangkan untuk dampak negatifnya yaitu bisa berpengaruh terhadap kehidupan sosial peserta didik dan kesenjangan sosial.
Camouflage um einen Wohnkomplex
Authors: Weingartner Gabriele , Siemann Holger
Published: June 2024

Holger Siemann, Das Weiszheithaus. Ein Jahrhundertroman. Dörlemann Verlag, Zürich 2017. 736 Seiten, 28 Euro
Erfahrungsreigen
Authors: Tröger Beate , Ernaux Annie
Published: June 2024

Annie Ernaux, Die Jahre. Aus dem Französischen von Sonja Finck. Suhrkamp, Berlin 2017. 256 Seiten, 18 Euro
Mythos Bachmann
Authors: Tröger Beate , Hartwig Ina
Published: June 2024

Ina Hartwig, Wer war Ingeborg Bachmann? Eine Biographie in Bruchstücken. S. Fischer Verlag, Frankfurt a. M. 2017. 320 Seiten, 19,99 Euro
Stadt wie ein Phönix
Authors: Zoppellaro Simone , Suvak Sefa Inci , Taufiq Suleman
Published: June 2024

Sefa Inci Suvak und Suleman Taufiq (Hrsg.), Benimist – Mein Istanbul. Benim Istanbul’um. My Istanbul. Edition Esefeld & Traub, Stuttgart 2017. 320 Seiten mit Fotos von Cana Yilmaz und Iskender Muhlis Kenter, 53 Euro
großes Lesevergnügen
Authors: Rüdenauer Ulrich , James Henry
Published: June 2024

Henry James, Lady Barbarina. Aus dem Englischen übersetzt sowie mit Anmerkungen und einem Nachwort versehen von Karen Lauer. Dörlemann Verlag, Zürich 2017. 224 Seiten, 21 Euro
Verfemt, verfolgt, ermordet
Authors: Saalfeld Lerke von , Schädlich Hans Joachim
Published: June 2024

Hans Joachim Schädlich, Felix und Felka. Rowohlt Verlag, Reinbek 2018. 201 Seiten, 19,95 Euro
"Wie viel Schmerz in einem schlummert"
Authors: Stroheker Tina , Fritz Susanne
Published: June 2024

Susanne Fritz, Wie kommt der Krieg ins Kind. Wallstein Verlag, Göttingen 2018. 261 Seiten, 20 Euro
Keine Schonzeit
Authors: Kahrs Axel , Bok Pauline de
Published: June 2024

Pauline de Bok, Beute. Mein Jahr auf der Jagd. Roman. Aus dem Niederländischen von Gregor Seferens. C. H. Beck Verlag, München 2018. 272 Seiten, 19,95 Euro
Geburt eines Dichters
Authors: Hübner Klaus , Delius Friedrich Christian
Published: June 2024

Friedrich Christian Delius, Die Zukunft der Schönheit. Erzählung. Rowohlt Berlin Verlag 2018. 92 Seiten, 16 Euro
Rumänien abseits der Klischees
Authors: Hübner Klaus , Nowotnick Michaela
Published: June 2024

Wohnblockblues mit Hirtenflöte. Rumänien neu erzählen. Hrsg. von Michaela Nowotnick und Florian Kührer-Wielach. Verlag Klaus Wagenbach, Berlin 2018. 239 Seiten, 13,90 Euro
Gefühlserinnerungen
Authors: Ferchl Irene , Seethaler Robert
Published: June 2024

Robert Seethaler, Das Feld. Roman. Hanser Berlin, 2018. 239 Seiten, 22 Euro
Land der Verzauberung
Authors: Keuler Dorothea , Shelley Mary
Published: June 2024

Mary Shelley, Streifzüge durch Deutschland. Reiseberichte. Hrsg., übersetzt und mit einem Nachwort versehen von Michael Klein. Morio Verlag, Heidelberg 2018. 200 Seiten, 19,95 Euro
Erwachendes Begehren
Authors: Tröger Beate , Cortázar Julio
Published: June 2024

Julio Cortázar, Die Katzen. Erzählung. Aus dem Spanischen und mit einem Nachwort von Henriette Terpe und Frank Henseleit. Lilienfeld Verlag, Düsseldorf 2018. 128 Seiten, 18 Euro
wahren Schätze
Authors: Ferchl Irene , Adimi Kaouther
Published: June 2024

Kaouther Adimi, Was uns kostbar ist. Roman. Übersetzt von Hilde Fieguth. Lenos Verlag, Basel 2018. 224 Seiten, 22 Euro
gleichgültige Meer
Authors: Böttiger Helmut , Ott Karl-Heinz
Published: June 2024

Karl-Heinz Ott, Und jeden Morgen das Meer. Roman. Hanser Verlag, München 2018. 143 Seiten, 18 Euro
Schlichtweg genial
Authors: Tröger Beate , Stripling Robert
Published: June 2024

Robert Stripling (Hrsg.), Verpasste Hauptwerke. mikrotext Verlag, Berlin 2018. 328 Seiten, 21,99 Euro
blauen Sommer sind vorbei
Authors: Mylo Ingrid , Wondratschek Wolf
Published: June 2024

Wolf Wondratschek, Selbstbild mit russischem Klavier. Roman. 271 Seiten, 22 Euro
Wolf Wondratschek, Gesammelte Gedichte. Kassette mit 13 Bänden. 58 Euro Beide im Ullstein Verlag, Berlin 2018
Banco de España Business Activity Survey: 2024 Q2
Authors: Fernández Cerezo Alejandro , Izquierdo Mario
Published: June 2024

Rationale

The Banco de España Business Activity Survey (EBAE) provides highly valuable, real-time information on a broad sample of Spanish firms’ turnover, employment, costs and prices, and the constraints on their activity. This is particularly helpful for diagnosing current economic developments.

Takeaways

•Firms have perceived a pronounced increase in turnover in 2024 Q2, after reporting declines in the previous three quarters, although there continues to be high cross-sector heterogeneity.

•Inflationary pressures have eased in Q2, in terms of both the cost of inputs and selling prices and labour costs. Firms expect this easing of inflationary pressures to continue one year ahead.

•Business activity has benefited from a decrease in the adverse impact of the constraints, although concerns over labour shortages and economic policy uncertainty remain high.
A test-based strategy for early return to work for health-care workers with COVID-19 during the Omicron wave, Brunei Darussalam, 2022
Authors:   Occupational Health Division, Ministry of Health, Brunei Darussalam, Lai Alice ,   Pengiran Anak Puteri Rashidah Sa’adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam, Trivedi Ashish ,   Occupational Health Division, Ministry of Health, Brunei Darussalam
Published: June 2024

Objective: This paper summarizes and evaluates a test-based strategy for early return to work for health-care workers (HCWs) with mild coronavirus disease in Brunei Darussalam during the Omicron wave in February 2022 and compares the characteristics of HCWs by how long it took them to return to work. Methods: The early return-to-work strategy involved testing on day 3 of infection with reverse transcription–polymerase chain reaction and with a rapid antigen test on days 5 and 6 or days 5 and 7. Data about infected HCWs were extracted from the Ministry of Health’s public health surveillance database. Percentages and proportions were used for descriptive statistics, and Pearson’s chi-squared test and the paired t-test were used to compare return-to-work patterns with demographic factors and vaccination status of the HCWs, as well as between cycle threshold (Ct) values and occupational groups of HCWs. Results: From 15 February to 15 March 2022, a total of 1121 HCWs were notified as being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Of these, 175 (15.6%) were able to return to work on day 4 of their infection, 153 (13.6%) on day 6 and 268 (23.9%) on day 7; 525 (46.8%) required 10 days of home isolation. Statistically significant associations were observed between return-to-work periods and occupational group (P < 0.01) and Ct value (P < 0.01), but not between return to work and age, sex or vaccination status. Discussion: This test-based strategy ensured a balance between mitigating a shortage of HCWs and enabling them to return to work early without compromising their safety and that of their patients.
Feral pigs as a reservoir for zoonotic and transboundary diseases in the Western Pacific Region
Authors:   College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia, Adamu Andrew ,   Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia, Firth Cadhla ,   College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia; EcoHealth Alliance, New York City, New York, United States of America, Gummow Bruce ,   College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia, Hickson Roslyn ,   Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia; Commonwealth Scientific Industrial Research Organisation, Townsville, Queensland, Australia, Hoskins Andrew ,   College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia; Commonwealth Scientific Industrial Research Organisation, Townsville, Queensland, Australia, Horwood Paul ,   College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia; Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia
Published: June 2024

Feral pigs are known as triple-threat pests due to their impact on health, agriculture and the ecosystem. Recent emerging infectious disease outbreaks have emphasized their role as reservoirs and amplifiers of disease and highlight the need for increased surveillance in the Western Pacific Region.
Letter to the Editor: Pathogens detected from patients with acute respiratory infections negative for SARS-CoV-2, Saitama, Japan, 2020
Authors:   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Arima Yuzo , Tsuchihashi Yuuki ,   Center for Field Epidemic Intelligence, Research and Professional Development, National Institute of Infectious Diseases, Tokyo, Japan, Takahara Osamu ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Shimbashi Reiko ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Arashiro Takeshi ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan, Kasamatsu Ayu ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Kobayashi Yusuke ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan; Center for Field Epidemic Intelligence, Research and Professional Development, National Institute of Infectious Diseases, Tokyo, Japan, Komase Katsuhiro ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Takahashi Takuri ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Otani Kanako ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Yan Fangyu ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Kamigaki Taro ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan, Taniguchi Kiyosu ,   National Hospital Organization Mie National Hospital, Mie, Japan, Suzuki Motoi ,   Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan
Published: June 2024

Utilizing data presented in the article by Miyashita et al., we illustrate the importance of testing data when assessing surveillance data. Accounting for the number of tests (denominator) and positivity (proportion of tests positive for a specific pathogen(s)) improves data interpretation in ways not possible from numerator case data alone.
Suplementación de noni (Morinda citrifolia) en la producción de tilapia roja (Oreochromis sp.)
Authors: Donis-Salazar Reina Denisse , Paz Patricio E.
Published: June 2024

La acuacultura es uno de los métodos más eficientes y sostenibles para la producción de proteína de alta calidad. Debido a su alto potencial esta industria ha tenido un crecimiento acelerado buscando alternativas que maximicen la producción, y minimicen la presencia de enfermades. Por lo cual, el uso de antibióticos tuvo un gran auge, pero debido a efectos contraproducentes y concientización de los consumidores el uso de estos productos ha sido prohibido en muchos países. Por lo cual, la implementación de inmunoestimulantes naturales, ha cobrado alta significancia. Este estudio tiene como objetivo evaluar el efecto de suplementación de noni (Morinda citrifolia) en la alimentación de tilapia roja (Oreochromis sp.) y evaluar su efecto en los parámetros productivos de ganancia diaria de peso, índice de conversión alimenticia, peso final y sobrevivencia. El estudio se realizó en 16 estanques, los cuales fueron divididos en cuatro tratamientos: tratamiento control, tratamiento con extracto de fruto de noni, tratamiento con harina de hoja de noni y tratamiento con producto comercial VIUSID; con cuatro repeticiones por tratamiento. Se utilizó un Diseño Completamente al Azar (DCA) y se empleó un ANDEVA con un valor de significancia de P ≤ 0.05. Se analizaron los resultados por medio del programa SAS, utilizando la prueba de distancias múltiples DUNCAN. La suplementación de extracto de noni y harina de hoja generaron resultados significativos en los distintos parámetros productivos evaluados en comparación con el tratamiento control y el tratamiento con VIUSID, obteniendo los mejores valores para las variables de ganancia diaria de peso (0.308 y 0.268 g vs 0.184 y 0.206 g), peso final (9.121 y 8.562 g vs 7.124 y 7.361 g), índice de conversión alimenticia (2.361 y 2.374 vs 0.184 y 0.206) y biomasa final (329.375 y 319.688 g vs 278.438 y 309.688 g). Por lo cual, se pudo concluir que la implementación de noni como prebiótico en la producción de tilapia roja tiene un alto potencial debido a que no se presentaron efectos negativos en la calidad de agua y por las mejoras en los parámetros productivos evaluados.
Recuperación y Satisfacción Anestésica de los Pacientes Postoperados de Cirugía General
Authors: Rodríguez Villeda Cinthia Waleska
Published: June 2024

En anestesiología influyen varios factores para garantizar satisfacción y calidad adecuada, aunque la satisfacción va encaminada a evaluarse en todo tipo de anestesia aplicada, esta revisión se enfocó en el análisis de la satisfacción de los pacientes sometidos a anestesia general. La satisfacción en la recuperación postopera- toria del paciente depende de lo que espera previo a su procedimiento quirúrgico, el tiempo de espera para la realización de la cirugía, la información que se le brinda al paciente, el manejo adecuado de la ansiedad. La mayoría de las mediciones de los indicadores utilizados para evaluar la calidad de la recuperación posanestésica involucran situaciones desde la percepción del personal de salud y poco sobre la percepción del paciente, de tal manera que en las investigaciones recientes se incluyen variables que evalúan el estado del paciente , como el dolor, vómito, tiempo para despertar entre otras, como parámetros para conocer su satisfacción. Para analizar esta problemática es necesario identificar que las personas hospitalizadas para una intervención quirúrgica desde ya tienen miedo a la cirugía, anestesia y a las diferentes complicaciones de la intervención propiamente dicha, si le sumamos la falta de empatía del personal de salud aumentaremos un desequilibrio emocional que afectara en su recuperación. Se debe tomar en cuenta que una adecuada adaptación psicológica preoperatoria suele ser seguida por una buena adaptación postoperatoria; de tal manera que el estado psíquico del paciente influye en su recuperación posanestésica.
Careful choice of carbonyl-containing cmps, and optimisation of Buchwald-Hartwig crosscoupling reaction conditions
Authors:   Scientific production and technical center “Zhalyn”, Mukhanov D.K.
Published: June 2024

In this study, new nitrogen-rich conjugated microporous polymers were synthesized using the Buchwald-Hartwig cross-coupling reaction. The synthesized polymers were characterized using various methods, including X-ray diffraction (XRD), ultraviolet-visible-near-infrared (UV-Vis-NIR) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and pore size distribution (PSD) determination using non-local density functional theory (NLDFT). The results provide important information about the structure and properties of synthesized materials, which contributes to a deeper understanding of their characteristics. The obtained characteristics of the material allow us to judge the quality and purity of the obtained polymers, which is important for further research, as well as serve as a basis for the development of new synthesis methods or improvement of existing technologies.
Ecological problems of technogenic land pollution in the republic of Кazakhstan
Authors:   Al-Farabi Kazakh National University, Yessimsiitova Z.B. ,   Scientific production and technical center “Zhalyn”, Konysbayeva A.A. ,   Al-Farabi Kazakh National University, Тoktar М. ,   Scientific production and technical center “Zhalyn”, Akimbayeva A.B. ,   Scientific production and technical center “Zhalyn”, Nuraly A.M. ,   Scientific production and technical center “Zhalyn”
Published: June 2024

A large territory in Kazakhstan is distinguished by the diversity of soils and the complex structure of the soil cover. Soil contamination with heavy metals, especially in the vicinity of large cities and industrial centers, is one of the environmental problems. Of great scientific and practical interest is the determination of the content of heavy metals in soil, their transformation and entry into food and feed. The accumulation of heavy metals in the soil leads to an increase in their concentration in plants, which affects public health. Therefore, the study and identification of areas with high levels of heavy metals in the soil are of increasing importance. The article summarizes the results of a study of soil and vegetation cover in areas adjacent to mining enterprises factories for the production of non-ferrous and rare metals.
Methods for the preparation and determination of inulin and technological parameters of jerusalem artichoke Helianthus tuberosus L
Authors:   Scientific production and technical center “Zhalyn”, Rysbayeva Ye.Zh. , Lessova Zh.T. ,   Almaty Technological University, Assanova N. ,   Almaty Technological University
Published: June 2024

Inulin is a polysaccharide of plant origin, soluble dietary fiber is considered a prebiotic. It is not digested by digestive enzymes, the intestinal microflora is completely destroyed and promotes the reproduction of beneficial bifidobacteria, suppressing the effects of harmful pathogenic bacteria. Inulin is a polypructosan that can be obtained as an amorphous powder and crystals, easily soluble in hot water and difficult to dissolve in cold water. The most promising source of flora of Kazakhstan for inulin is the soil pear Helianthus tuberosus L. It belongs to the group of available medicinal plants. It is found in almost all regions of Kazakhstan. In this work, the methods of inulin isolation from the composition of the soil pear Helianthus tuberosus, a medicinal plant of Kazakhstan, and indicators of technological parameters (specific, bulk, bulk masses and porosity) are determined. The quantitative determination of inulin was carried out using a spectrophotometric method.
FIGHTING ANTIMICROBIAL RESISTANCE:
A MARATHON, NOT A SPRINT
Authors:   1. Faculty of Biology, Coordinator of the Life, Environmental and Earth Science Division of the Research Institute of the University of Bucharest, Chifiriuc Mariana-Carmen
Published: June 2024

In the realm of infectious diseases,
antimicrobial resistance (AMR) has emerged
as a formidable adversary, challenging our
collective efforts to safeguard human health.
This natural phenomenon, augmented by
the significant selective pressure exerted
by antimicrobials and other categories of
pollutants, threatens to undo decades of
medical progress, rendering once-manageable
infections dangerous. This editorial synthesizes
the latest insights and data on AMR,
emphasizing the urgent need for a coordinated,
multifaceted response.
ASSOCIATION OF EPIGALLOCATECHIN-3-GALLATE AND QUORUM
SENSING MOLECULES TO MODULATE BIOFILMS IN CLINICAL
PSEUDOMONAS AERUGINOSA STRAINS
Authors:   1.Microbiology & Immunology Department, Faculty of Biology, University of Bucharest, Bucharest, Romania
2.Research Institute of the University of Bucharest-ICUB, University of Bucharest, Bucharest, Romania
3.Van Xuan University of Technology, Nghe An, Vietnam, Van Luc Tran , Marinescu Florica ,   1.Microbiology & Immunology Department, Faculty of Biology, University of Bucharest, Bucharest, Romania
2.Research Institute of the University of Bucharest-ICUB, University of Bucharest, Bucharest, Romania, Curuțiu Carmen ,   1.Microbiology & Immunology Department, Faculty of Biology, University of Bucharest, Bucharest, Romania
2.Research Institute of the University of Bucharest-ICUB, University of Bucharest, Bucharest, Romania
Published: June 2024

Pseudomonas aeruginosa is one of the most common multidrug resistant opportunistic pathogens. This
Gram-negative bacterial species uses intricate molecular signaling paths to regulate its resistance and virulence,
namely quorum sensing (QS) mechanism. Since the discovery of QS inhibitors (QSI), targeting virulence genes to
suppress bacterial pathogenesis without causing significant growth inhibition has been a promising approach
for the treatment of P. aeruginosa infections. The use of natural compounds as potential QS modulators is an
appealing anti-pathogenic strategy. In this study, we have evaluated the ability of epigallocatechin-3-gallate
(EGCG), a potent tea tree derived bioactive molecule to act as a biofilm inhibitory agent in P. aeruginosa and
potentate modulatory properties of QS signaling molecules. The results show that subinhibitory EGCG
concentrations suppresses attachment and biofilm formation in P. aeruginosa resistant strains, without
inhibiting planktonic cells growth. Also, the results proved that EGCGs acts as a QSI decreasing the growth
of attached bacteria.
FIRST DHA-PRODUCING KLEBSIELLA PNEUMONIAE ISOLATED FROM A
URINARY TRACT INFECTION IN ROMANIA
Authors:   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Chelaru Edgar-Costin , Muntean Mădălina-Maria ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Hogea Mihai-Octav ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: June 2024

Beta-lactamase production is a major antibiotic resistance determinant in Enterobacterales. A carbapenemresistant Klebsiella pneumoniae isolate was recovered from routine screening in a tertiary urology hospital. The
strain was evaluated phenotypically using the interpretative reading of an extended disk diffusion antibiogram
and for specific antibiotics, the minimum inhibitory concentration (MIC) was performed. Phenotypic tests
were further performed such as the CIM, mCIM, rCIM, the double disk synergy test, Blue Carba Test, and NGTEST® CARBA-5 and carbapenemase production was not confirmed. The isolate was sequenced and multiple
resistance genes were identified. This report signifies the first description of DHA-1 in a Klebsiella pneumoniae
strain in Romania.
PROBIOTICS ABLE TO COUNTERACT BIOFILM-RELATED
ORAL INFECTIONS
Authors:   Microbial Biofilm Laboratory, Santa Lucia Foundation Research Hospital, Rome, Italy, Gianfranco Donelli
Published: June 2024

The potential clinical applications of probiotics are more and more widening, a growing evidence being accumulated on their efficacy in the prevention and treatment of different oral disturbances or diseases, including oral malodor, gingival inflammation, dental caries and periodontal diseases. Taking into consideration the widespread ability of microbial pathogens to generate persistent biofilm-related infections, an attractive proposal is to administer probiotics to prevent or counteract biofilm development.
RELATIONSHIP BETWEEN CHLAMYDIA INFECTION
AND FEMALE INFERTILITY
Authors:   Filantropia Clinical Hospital, Bucharest, Romania, Ciocârlan Maria Alexandra , Peltecu Gheorghe ,   1.Filantropia Clinical Hospital, Bucharest, Romania
2.Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: June 2024

Female infertility is a significant current health problem that affects women worldwide, causing a high
burden on the public health system. Many factors may lead to infertility and Chlamydia trachomatis infection
has been stated as one of them. C. trachomatis is the most common sexually transmitted infection, with 1 in 20
sexually active young women aged 14-24 suffering from it. Clinical symptoms may include vaginal discharge,
spontaneous bleeding, dysuria, dyspareunia, or pelvic pain, but in most cases, this bacterial infection is
asymptomatic. Undiagnosed or repeated infections in women may seriously harm the female’s reproductive
system, leading to pelvic inflammatory disease, tubal infertility, and chronic pelvic pain. Through this study,
we aimed to search for the relationship between Chlamydia trachomatis infection and female infertility and to
highlight the importance of screening among the categories of people at high risk of contracting the infection.
Enhanced Brain Tumor Diagnosis Through Differential and Canonical Quadri –Partitioned Neutrosophic Set Classification Methods:A Comparative Study
Authors:   KGiSL institute of Technology,Coimbatore,India, A. A. ,   Department of Mathematics, K. Ramakrishna College of Engineering (Autonomous), Tiruchirapalli - 621112,   Department of Mathematics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, India.,   Department of Mathematics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, India.,   Department of Mathematics, Nirmala College for Women, Red Fields, Coimbatore, India.,   Department of Mathematics, Nirmala College for Women, Red Fields, Coimbatore, India., Sugapriya P. , .. D. , .. S. Santhosh , .. K. , Irudayam F. Nirmala
Published: June 2024

An early cancer diagnosis is carried out for adequate management of diseases. Magnetic resonance imaging (MRI) is most commonly preferred method for cancer diagnosis. Due to the uncontrolled and rapid growth of cells, brain tumor is occurred. If not treated at a preliminary phase, it may lead to death. Thus, a noteworthy prerequisite for a successful treatment outcome is an early and precise diagnosis.Many conventional methods are discussed for performing efficient tumor detection. But, conventional classification methods not distinguish MRI as primary and metastases tumors in an accurate manner. Therefore, the performance comparison of deep learning-based classification (i.e., Differential Quadri-Partitioned Neutrosophic Interval-valued Polynomial Attention-based Deep CNN (DQNI-PADCNN) method and Canonical Quadri-Partitioned Neutrosophic Set based Otsuka–Ochiai Deep Recurrent Neural Network (CQNS-ODRNN) method) is introduced to provide exact image classification results. The brain MRI images are considered as an input. MRI image classification is carried out through CNN and RNN to find the brain tumor disease. Before the classification process, input images are de-noised. The noise-removed images are get segmented to identify the region of interested regions. Later, the images are classified into four classes such as glioma, meningioma, no tumor, and pituitary classes to detect the brain tumor. Both classification methods use Quadri-Partitioned Neutrosophic set for categorizing the images. Depending on CNNs and RNNs achievement in handling intricate tasks, an optimal multi-class brain tumor diagnosis is carried out. Experimental evaluation is implemented using MATLAB 2017 for brain tumor detection with the Brain Tumor MRI dataset. To the total number of MRI images, the various performance metrics are calculated in terms of sensitivity, specificity, accuracy, and time for the detection of brain tumors.
CPRE En el diagnóstico y tratamiento de litiasis coledociana en pacientes de Venezuela
Authors: Castillo Arrieta Yhonny , Figueroa Castillo Frank José , Parra Rosargelis , Romero José Ignacio , Castillo Ayala Diego Alejandro , D’ammassa Ana María , Traviezo Valles Luis Eduardo
Published: June 2024

Introducción.  La escasa información reciente, en Venezuela, sobre la utilidad de la colangiopancreatografía retrógrada endoscópica (CPRE) para el diagnóstico y tratamiento de la litiasis coledociana, motivó el presente manuscrito. Metodología. Se realizó un estudio descriptivo transversal en 130 pacientes con edades comprendidas entre los 15 y 97 años, procedentes de 12 estados de Venezuela, a los cuales se les realizó la CPRE para el estudio de la litiasis coledociana como principal motivo de consulta. Resultados. 24 pacientes (18,5%) presentaron esta patología, diagnosticada posterior al CPRE, y de estos 24, diez pacientes ya venían con una impresión diagnostica de litiasis coledociana, mientras que los otros catorce presentaban una impresión diagnóstica menos precisa o distinta. Se pudo resolver 21 de las litiasis coledocianas abordadas, las otras tres fueron complejas e imposibles de resolver en este primer intento. Conclusión. La CPRE sigue siendo, en Venezuela, una importante herramienta en el diagnóstico y tratamiento de la litiasis coledociana.
Editorial
Authors: Cairol Barquero Andrés
Published: June 2024

La educación médica plantea un reto muy complejo a los profesores que imparten sus clases presenciales, virtuales o prácticas. Ante la gran cantidad de herramientas de inteligencia artificial (IA) que han surgido en los últimos años, el uso adecuado de éstas, para lograr incorporarlas a los planes de lección, es un reto que cada día es más complejo. Los estudiantes tienen a su disposición herramientas como el ChatGTP que en tiempo real responde a cualquiera de las preguntas que se le plantean y puede según la capacidad de quién le pregunte, diseñar casos clínicos con absoluto detalle. Tal y como lo describe Charles Darwin, “No es la más fuerte de las especies la que sobrevive, ni la más inteligente, sino la que mejor responde al cambio”, por lo que adaptarse a esta nueva tecnología no solo es un desafío sino también una necesidad.
The Family Asteraceae: A review of phytochemical contents and anticancer activity of selected members
Authors: Ukwubile Cletus , Malgwi Troy , Menkiti Nnamdi , Ikpefan Emmanuel
Published: June 2024

Background: The Asteraceae is one of the largest families among the angiosperms, consisting of over 1,620 genera and 23,600 species of herbs, shrubs, and trees which are found in the world. They are unique due to the possession of composite inflorescence heads and single-seed achene fruits. Members exert various levels of pharmacological activities such as anticancer, anti-inflammation, antimicrobial, antimalaria and antidiabetic due to the presence of phytoconstituents contained in their leaves, stembarks, flowers, and roots. Some of the members have shown potent cytotoxic effects on various cancers like breast, cervical, ovarian and blood cancers.
Main body: Due to the side effects caused by chemotherapeutic drugs on cancer patients, there is a paradigm shift towards natural remedies for cancer by researchers. Studies carried out on different species belonging to the Asteraceae showed that they possessed potential cytotoxic and therapeutic effects on cancer cells like MCF-7 breast cancer cells, liver, leukaemia, ovarian and cervical cancer. The anticancer potentials of the Asteraceae were reported to have been due to the presence of phytoconstituents isolated from the various parts of some selected members. These metabolites or phytoconstituents include flavonoids, sesquiterpenes, alkaloids, and various types of glycosides. These compounds were found to inhibit angiogenesis, prevent metastasis and induce cellular apoptosis in cancer cells. Various techniques have been deployed to characterize and elucidate the chemical structures of isolated compounds from some members. These techniques are UV-vis, FTIR, GC-MS, LC-MS and NMR. This present review revealed the presence of potential anticancer compounds and the need to screen more members of the family for their anticancer activities against various cancer cells. In this case, various search engines such as Google Scholar, Science Direct, PubMed, BASE, ResearchGate, DOAJ, Science.gov, Semantic Scholar and CORE were used in this study.
Conclusion: This review showed that despite the numerous beneficial anticancer therapeutic potentials of the Asteraceae, only a few members of the family were screened for their anticancer activity. There is a need, therefore, for more studies on many members towards the isolation of potential anticancer compounds. This will help in the discovery of novel compounds that will serve as lead compounds for anticancer drug development.
Intentionnalité et spiritualité narratives dans Anne, ou quand prime le spirituel et Le Sang des autres de Simone de Beauvoir
Authors: Bodil Kalvik Liva
Published: June 2024

Mon article porte sur la contradiction inhérente à la notion de spiritualité telle qu’elle apparaît dans les romans Le Sang des autres (1945) et Anne, ou quand prime le spirituel (1935/1979) de Simone de Beauvoir. Le spirituel est un élément constitutif du discours romanesque de Beauvoir, partagé entre « pure philosophie » et fiction. Pour interpréter dans ces récits l’évolution spirituelle des personnages principaux, j’aurai recours à la théorie de Mikhaïl Bakhtine sur l’esthétique du héros romanesque, ainsi qu’aux propos philosophiques du Deuxième Sexe (1949). Ces textes me serviront à illustrer la diversité de la poétique phénoménologique de Beauvoir, laquelle est surtout une poétique de l’ambiguïté liée au choix : dans Le Sang des autres et Anne, ou quand prime le spirituel, Beauvoir met en scène la notion de choix à travers ses protagonistes, qui se distinguent les uns des autres notamment sur la question de savoir s’il faut accepter ou non une morale de l’ambiguïté.