bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of daratumumab in relapsed or refractory multiple myeloma patient: A meta-analysis and literature to review
Authors: Tauseef Abubakar , Zafar Maryam , Silberstein Peter , Nahas Joseph , Frederickson Thomas , Abodunrin Faith , Abbas Anum , Arshad Wafa , Lateef Noman , Rangoonwala Hussain , Albagoush Sara , Mirza Mohsin
Published: June 2022

ABSTRACT

Introduction:

With an increase in number of cases of relapsed or refractory multiple myeloma (RRMM), scientist have discovered various combination of medications among which one is daratumumab, Daratumumab is a mono-clonal antibody which attacks CD-38 markers present in abundance on the surface of myeloma cells and is used universally for the treatment of primary newly diagnosed multiple myeloma patients.

Methods and Methodology:

This meta-analysis was conducted according to Cochrane Collaboration guidelines in which initially 679 articles were evaluated for relevance on abstract level followed by full text screening of final list of 45 articles. Out of the 45 articles, only 10 articles qualified for selection criteria for eligibility. Three Phase 3 randomized control clinical trials which includes primary outcomes of progression free span and secondary outcomes including complete response, partial response or very good partial response and adverse effects reported were included in this study.

Results:

A total of three studies including 1533 patients (849 in Daratumumab treatment group while 684 patients in control group) were included in the study. All three of these studies were phase 3 clinical trial conducted to observe the role of daratumumab in relapsed and refractory multiple myeloma. Mean age reported was 65 years in both treatment and control groups. This study showed that daratumumab improves primary and secondary outcomes including progression free span, overall response rate, very good partial response, and complete response. However, daratumumab increases drug induced adverse effects.

Conclusion:

Our study confirmed that daratumumab in combination therapy improved primary and secondary outcomes when compared with platinum-based chemotherapy, but more adverse effects were reported in the combination group. So, we recommend that combination therapy should include daratumumab in treatment of relapsed and refractory multiple myeloma patients.
Effect of body mass index (BMI) on pulmonary functions in children of 6-14 years of age: A cross-sectional study
Authors: Satapathy Amit K. , Das Rashmi R. , Mahapatro Samarendra , Panigrahi Manoj K. , Bandopadhaya Debapriya
Published: June 2022

ABSTRACT

Background:

Over-weight/obesity is a new global pandemic affecting children with prevalence up to 36%. It is responsible for metabolic syndrome and its future complications in children; however, its effect on lung functions in children is not well studied.

Aim:

To compare lung function tests [forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), FVC, and % predicted] of children with over-weight/obesity to that of normal children.

Method:

it is a hospital-based cross-sectional study. Children of 6–14 years of age with over-weight [body mass index (BMI) >85th centile] and obesity (BMI >95th centile) attending the pediatrics outpatient department (OPD) were included. Age-matched children attending the OPD during the study period were selected as controls. Demographic and anthropometric details were collected, and pulmonary function tests were carried out in included children.

Results:

A total of 103 children were included (over-weight/obese = 56, control = 47). The percent predicted (%) FEV1 (86.23 ± 12.84 vs 91.77 ± 8.68) and FVC (81.93 ± 12.12 vs 88.62 ± 10.87) were significantly lower in the obese/over-weight group as compared to control group. A signification negative correlation was found between FEV1 (%) and FVC (%) and that of BMI and waist-hip ratio (WHR).

Conclusions:

Pulmonary functions (FEV1, FVC) are found to be negatively correlated with BMI and WHR.
Frequency of suicide ideation and attempts and its correlates among inpatients with depressive disorders at a tertiary care center in North India
Authors: Belsiyal C Xavier , Rentala Sreevani , Das Anindya
Published: June 2022

ABSTRACT

Background:

Suicidal ideation is higher in psychiatric patients, particularly in those with depressive disorders. It tends to be a precursor to suicide attempts.

Aim:

To estimate the frequency of suicide ideation and attempts and their sociodemographic and clinical correlations among the inpatients with depressive disorders at a tertiary care center in North India.

Methods:

A cross-sectional descriptive survey was carried out among 128 participants diagnosed with depressive disorders who were admitted from September 2019 to April 2021 at a tertiary care hospital, India, using a total enumerative sampling technique. The sociodemographic and clinical data (particularly on suicide) were supplemented with the Modified Scale of Suicide Ideation (to evaluate suicidality) and the Hamilton Depression Rating Scale (for the severity of depression).

Results:

The median suicide ideation score was 11 inter quartile range (IQR: 19), and the overall mean depression score of the sample was 22.74 standard deviation (SD = 6.24). About 87% reported moderate to severe suicidal ideas. Occupation (farmer) (P < 0.01), current medications (tricyclic antidepressant) (P < 0.05), and history of suicide (P < 0.05) were significantly associated with the severity of depression. However, only a history of suicide was significantly associated with the current suicidal ideation (P < 0.05). About 48% had a history of suicide attempts, and among those who were more severely depressed, intoxicated during a suicide attempt (P < 0.01), taken precautions against being interrupted (P < 0.05), and had an intention to die (P < 0.05) had a significant association with their suicide attempts.

Conclusion:

Among hospitalized patients with depressive disorders, suicidal ideation is common. The study reiterates the importance of screening for suicide, particularly in those with more severe depression in the inpatient setting.
A case report of sciatic hernia as a cause of sciatica and lower back pain: Diagnostic dilemma for family physicians
Authors: Kaur Navdeep , Kaur Narinder , Chhabra Harwinder Singh , Singh Manmeet , Singh Paramdeep
Published: June 2022

ABSTRACT

Degenerative changes in lumbosacral spine or disc bulges impinging on the thecal sac are the usual causes of sciatica. However peripheral compression of sciatic nerve in pelvis or lower limb presenting as sciatica is an uncommon entity. The sciatic hernia is a rare type of hernia. Due to the deep location of this pathology, the clinical examination would add little and imaging plays a pivotal role in diagnosis. We present a case of sciatica diagnosed with giant gluteal lipoma presenting as sciatic notch hernia and compressing sciatic nerve in the greater sciatic notch. Less than 100 cases are reported in the literature so far. The possibility of this rare diagnosis should be kept in mind by family physicians while evaluating patients of sciatica with no significant imaging findings in lumbosacral spine.
A Study on the perception of medical students using online teaching during covid -19 pandemic
Authors: Kumari Anita , Rani Sudha , Bara Mary Pushpa
Published: June 2022

ABSTRACT

Introduction:

COVID-19 has caused unprecedented disruption to the medical education process and the health care system worldwide. It has also affected clinical training and forced medical colleges to switch over to the online mode of teaching. This study aimed to learn about the experience and perception of undergraduate students regarding online learning and to study the advantage and disadvantages of online learning.

Method:

This was a cross-section study conducted among the undergraduate students of government medical colleges of Jharkhand. A validated electronic questionnaire was sent to students of all five government medical colleges in the google form. Response from 501 students was received and analyzed using SPSS software.

Result:

Only 30% of students were satisfied with the frequency, organization content, and preparedness of class. More than half of students were not satisfied with the preparedness, content, and frequency of online classes. Among various teaching methods, live online lectures were most common, and they were also preferred by the majority of students. Most of the students wanted a regular face-to-face classroom or hybrid teaching after the COVID-19 pandemic.

Conclusion:

The majority of the medical students preferred face-to-face teaching methods over online teaching methods. Lack of interpersonal interaction and poor infrastructure for online might be the reason for this. However, a hybrid method of learning can be included as a part of the medical curriculum that helps in better learning of medical students.
Prevalence and determinants of depression among primary healthcare workers in Jeddah, Saudi Arabia 2020
Authors: Aziz Ghaida Abdullah Mohammed , ALghfari Sara , Bogami Eman , Abduljwad Kholod , Bardisi Wedad
Published: June 2022

ABSTRACT

Objectives:

To estimate the prevalence and assess the levels of depression among primary healthcare workers (HCWs) and to explore the associated determinants.

Methods:

A multicenter, cross-sectional study was carried out at 10 primary healthcare centers (PHCCs) in Jeddah, Saudi Arabia (October 2020–December 2020) involving care- and non-care-related professions. A Patient Health Questionnaire-9 (PHQ-9) and two levels of depression severity were considered and analyzed separately as dependent variables, including moderately severe or severe (Level 1 depression, PHQ-9 score ≥15); and moderate-to-severe (Level 2 depression, PHQ-9 score ≥10) for screening depression. Demographic and professional factors and the presence of stressors in different life dimensions were analyzed as independent variables.

Results:

We received 256 valid participations with a female ratio = 2.56 and mean (SD) age = 35.7 (6.9) years. Nurses represented 43.8%, followed by physicians (21.1%), and dentists (13.3%). More than half were work stressors (52.7%), followed by social (30.5%), and health stressors (19.9%). The prevalence of Level 1 depression was 19.1% (95% CI = 14.5–24.5%), and was independently determined by female gender (odds ratio [OR] = 4.66, P = 0.006) and work stressors (OR = 3.08, P = 0.025). The prevalence of Level 2 depression (moderate-to-severe) was 36.3% (95% CI = 30.4–42.6%), and was independently determined by female gender (OR = 2.57, P = 0.013), work stressors (OR = 3.71, P = 0.004), and dentist position (OR = 4.12, P = 0.008).

Conclusion:

Primary care professionals are exposed to a high risk of depressive disorders, with significant contribution of work stressors. The issues related to psychological health and its relation to the working environment should be part of the organizational culture in all health institutions, both at the staff and managerial levels.
Knowledge, attitude, and practices toward tobacco control among rural community health care workers of primary subcenters in Belagavi district, Karnataka
Authors: Pai Khot Atrey J. , Ankola Anil V. , Sankeshwari Roopali M. , Choudhury Abhra Roy , Kumar K Ram Surath , Shah Mehul A.
Published: June 2022

ABSTRACT

Context:

Tobacco is the common cause to a number of illnesses affecting millions of individuals all over the world. Primary care physicians are the initial point of contact for tobacco users, yet reaching everyone is impossible. Therefore, it is important to understand community health workers attitude to render community services in tobacco cessation counseling.

Aim:

To assess knowledge, attitude, practices, and occupational barriers toward tobacco control among community health care workers in Belagavi district, Karnataka.

Settings and Design:

This cross-sectional study was conducted in various subcenters of Belagavi district, Karnataka.

Methods and Material:

Simple random sampling technique was employed and 220 participants were interviewed using an interviewer administered questionnaire comprising of 22 close ended questions. Reliability of the questionnaire assessed with Cronbach’s a value of 0.85, face validity 84%, and content validity ratio 0.78.

Statistical Analysis Used:

The data were analyzed using descriptive analysis, chi square analysis, correlation, and regression.

Results:

The mean knowledge score among Accredited Social Health Activist (ASHA) workers was 4.77 ± 2.11 and it was lower in Anganwadi workers 2.93 ± 2.55. There was a statistically significant difference in the attitude scores (P < 0.05) between the community health workers. The majority of the ASHA workers would spread awareness, on the other hand, Anganwadi workers did not take any specific step which showed statistically significant difference with a P value of 0.018.

Conclusion:

ASHA workers had been superior to Anganwadi workers with regard to knowledge and attitude toward tobacco control. However, knowledge regarding tobacco and its ill effects was below optimal level among community health workers which desires to thoroughly educate in the aspects of oral health and disorders as part of their training.
Epidemiological study of suicidal patients referred to Kowsar Hospital in Semnan
Authors: Safaie Nilufar , Mirmohammadkhani Majid , Allahgholi Yasaman , Behnam Behnaz , Abdollahi Masoumeh
Published: June 2022

ABSTRACT

Introduction:

Suicide is one of the public health challenges which affect the individual, family, and even society. Because of the fact that accurate data collection on suicide attempts in different population areas is necessary, this study was conducted to determine the epidemiological and demographic characteristics of suicidal patients in Semnan, Iran.

Materials and Methods:

The present descriptive-retrospective study was performed on the clinical files of 809 suicidal patients referred to Kowsar Hospital in Semnan during 2015–2018. Using a checklist, biographical information, and marital status, suicide methods, physical diseases, previous psychiatric diseases, causes of suicide, and outcomes of suicide were collected, and then, the data were analyzed using EXCEL software.

Results:

Out of 809 subjects, 27% had a history of chronic psychiatric diseases, 1% of the statistical population (12 people) died, and 99% of the people (797 people) survived. The prevalence of suicide attempts was higher among women, single people, housewives, and people in the age group of 18–24 years. Family issues have been cited as the cause of 495 cases (61%) of suicide attempts in our study.

Conclusion:

Since suicide attempts are more common among young single women because of family issues, this important issue should be given more attention by health policy makers in Semnan province.
Attitudes of primary care providers on early palliative care, in new community settings of Attica, Greece; a qualitative analysis
Authors: Panagiotou Irene , Liva Eleni , Kappos Ioannis , Skliros Eustathios
Published: June 2022

ABSTRACT

Background:

Early provision of palliative care globally can be achieved by primary health professionals. In Greece, a primary care reformation is currently under development; novel community units have been introduced, with the family physician working for the first time with an interdisciplinary team.

Objectives/Setting:

To explore the attitudes of such providers, on early palliative care in Attica. A clear understanding of primary care workforce attitudes would facilitate the National primary care strategic development.

Participants/Design:

Qualitative research design, with 3 focused-groups of 23 primary health care providers, including family physicians, nurses, health visitors, administrative assistants and sociologists. All were members of the Hellenic Association of Research and Education in Primary Care. Semi-structured question guides were used. Experiences, practices, needs and barriers were evaluated. Responses were audio recorded, transcribed, grouped under various themes, listed out and analyzed, through thematic analysis.

Results:

Three major themes were identified and all teams were able to: 1) Identify patient and family populations with palliative care unmet needs, early at diagnosis. 2) Respond to those needs by the holistic model of care and integrate strategies of early palliative care, working as a team. 3) Recognize barriers to the best-possible approach: a) lack of education on severe pain and grief management, b) lack of collaboration with experts, and c) instability of governmental decisions.

Conclusions:

Teams of primary care providers in Attica, could integrate early palliative care. Issues to be addressed include further education on pain and grief management, collaboration with palliative care experts and stability.
Profile of nonischemic dilated cardiomyopathy patients with long-term survival ≥10 years on medical therapy alone
Authors: Monga Inderjeet S. , Singh Parminder , Bahl Ajay
Published: June 2022

ABSTRACT

Background:

Most studies have focussed on short and medium-term survival in dilated cardiomyopathy (DCM) patients. We aimed to study the profile and changes in left ventricular ejection fraction (LVEF) of nonischemic DCM patients who survived more than 10 years on medical management alone.

Methods:

This was a retrospective analysis of patients in the nonischemic DCM cohort recruited from April 2003 to January 2007 with LVEF ≤40%. All patients who survived at least 10 years from the initial DCM diagnosis and were on medical therapy alone were included in the study.

Results:

Forty of 127 (31.5%) patients survived over 10 years. Mean follow-up duration was 145.48 ± 16.8 months. Baseline left ventricular (LVEF) was 30.01 ± 7.89%. Of these, 26 (65%) patients showed recovery of LVEF. Eight (30.8%) of these had a relapse following initial recovery. 14 patients (35%) did not show improvement in LVEF. Multivariate analysis showed that only variable associated with sustained recovery of LVEF was shorter QRS duration with a mean QRS duration of 95.2 ± 11.3 ms versus 117.4 ± 22.6 ms in the two groups (P < 0.001).

Conclusions:

31. 5% of patients with nonischemic DCM survived more than 10 years with medical therapy alone. Almost two-thirds of these long-term survivors showed recovery of LVEF. Narrow QRS duration predicted sustained recovery of LVEF.
Proliferative verrucus leukoplakia: A case series
Authors: Datta Mainak , Sinha Rupam , Sen Suman , Jha Harshvardhan , Deb Debarati
Published: June 2022

ABSTRACT

Oral proliferative verrucous leukoplakia (OPVL) is a rare form of oral leukoplakia first reported in 1985. It is a longterm progressive condition, which develops initially as a white plaque of hyperkeratosis that eventually becomes a multifocal disease with confluent, exophytic, and proliferative features. It has no racial preference with female predilection, associated with various factors including human papillomavirus (HPV) association, genetic susceptibility, and long-standing low-grade traumatic factors. The malignancy transformation rate varies from 0.13 to 17.5% with frequent recurrences. Here, we have reported two cases of PVL seen over the tongue and palate. It is confirmed by clinical and histopathological features and treated with Vitamin A and its supplements and a long-term follow-up showed no recurrence, and hence, Vitamin A has proven as a potent treatment option of PVL by its antioxidant and epithelialization property.
Do We Need to Vaccinate Every Child against Coronavirus Disease 2019 in India?
Authors: Kapoor Suraj
Published: June 2022

There has been a lot of debate around the coronavirus disease 2019 (COVID-19) vaccination of children throughout the globe, particularly with many seeing it as a prerequisite for the reopening of schools. Secondary data from government official sites, press information, latest articles, and newspapers were extracted and discussed in the article. Published literature in respect of COVID-19 vaccination in children reveals that the transmission of COVID-19 is much lesser by the children, with milder course especially among younger children. Further, the risk of transmission by the young children seems very less especially with the recent variant of concern, omicron, in which majority of the infected (80%) remain asymptomatic. Hence, the policymakers need to prioritize the pediatric beneficiary for the vaccination. Age-specific morbidity and mortality trends of the country as well as across the different countries may help in deciding the groups within the pediatric population requiring urgent vaccination. Reports suggests that the pediatric population benefitting the most will be the children with underlying comorbidities or medical condition like malignancy, heart diseases, lifestyle diseases including childhood diabetes, obesity, and hypertension, and renal abnormalities. Since the safety and effectiveness of recently launched COVID-19 vaccines needs exploration in pediatric age group, it may be prudent to have pediatric vaccination among the specific groups who are at higher risk of contracting the severe disease rather than going for mass vaccination drive.
Atherogenic index of plasma
Authors: Khosravi Arezoo , Sadeghi Masoumeh , Farsani Ehsan Shirvani , Danesh Manizheh , Heshmat-Ghahdarijani Kiyan , Roohafza Hamidreza , Safaei Ali
Published: June 2022

Background:

Plaque instability is a leading cause of morbidity and mortality in coronary artery disease (CAD) patients. Numerous efforts have been made to figure out and manage unstable plaques prior to major cardiovascular events incidence. The current study aims to assess the values of the atherogenic index of plasma (AIP) to detect unstable plaques.

Materials and Methods:

The current case-control study was conducted on 435 patients who underwent percutaneous coronary intervention due to chronic stable angina (stable plaques, n = 145) or acute coronary syndrome (unstable plaques, n = 290). The demographic, comorbidities, chronic medications, biochemical and hematological characteristics of the patients were entered into the study checklist. The baseline AIP was measured according to the formula of triglycerides/high-density lipoprotein logarithm. Binary logistic regression was applied to investigate the standalone association of AIP with plaque instability. Receiver operating curve (ROC) was depicted to determine a cut-off, specificity, and sensitivity of AIP in unstable plaques diagnosis.

Results:

AIP was an independent predictor for atherogenic plaque unstability in both crude (odds ratio [OR]: 3.677, 95% confidence interval [CI]: 1.521–8.890; P = 0.004) and full-adjusted models (OR: 15, 95% CI: 2.77–81.157; P = 0.002). According to ROC curve, at cut-point level of 0.62, AIP had sensitivity and specificity of 89.70% and 34% to detect unstable plaques, respectively (area under the curve: 0.648, 95% CI: 0.601–0.692, P < 0.001).

Conclusion:

According to this study, at the threshold of 0.62, AIP as an independent biomarker associated with plaque instability can be considered a screening tool for patients at increased risk for adverse events due to unstable atherosclerotic plaques.
Quantity of the antigens of Streptococcus mutans serotype e and Candida albicans and its correlation with the salivary flow rate in early childhood caries
Authors: Bachtiar Endang Winiati , Kusuma Vanya A , Gultom Ferry P , Soejoedono Retno D
Published: June 2022

Background:

Streptococcus mutans involved in caries pathogenesis is classified into four serotypes, namely serotypes c, e, f, and k. Candida albicans can be found in the plaque of children with early childhood caries (ECC). Aims: The aim of this study was to analyze the quantity of the antigens of S. mutans serotype e and C. albicans and its correlation with the salivary flow rate in ECC.

Materials and Methods:

The antigen quantities of caries plaque samples and caries-free were determined using an enzyme-linked immunoassay with 450-nm optical density.

Results:

There was a significant difference between the quantity of S. mutans serotype e and C. albicans antigens in each salivary flow rate category (P < 0.05). The relationship between the antigen quantity of S. mutans serotype e and C. albicans was r = 0.624 (P > 0.05) for caries plaque samples and r = 0.628 (P > 0.05) for caries-free samples.

Conclusion:

the antigen quantities of S. mutans serotype e and C. albicans and the salivary flow rate might correlate to the pathogenesis of ECC.
Research Progress on the Pharmacological Mechanisms of Chinese Medicines that Tonify Qi and Activate Blood Against Cerebral Ischemia/Reperfusion Injury
Authors: Zheng Xiao-Yu , Zhang Ye-Hao , Song Wen-Ting , Chang Dennis , Liu Jian-Xun
Published: June 2022

Cerebral ischemia-reperfusion injury (CIRI) refers to a pathological phenomenon that aggravates the injury after the restoration of blood perfusion and oxygen supply to the cerebral ischemia-induced tissues and organs, with a relatively high incidence. The traditional Chinese medicine (TCM) believes that Qi deficiency and blood stasis are the cause of CIRI. Therefore, Chinese medicine for tonifying Qi and activating blood is regarded as an important choice for the treatment of CIRI. In recent years, it has been found that many Chinese herbal medical ingredients and compound Chinese medicine (CCM) have significant anti-CIRI effects, and their mechanisms of action mainly include improving brain blood supply, neuroprotection, regulating signal pathways such as TLR4/HO-1/Bcl-2, protecting mitochondrial function, regulating related protein levels, and regulating oxidative molecule levels. This article summarizes and introduces the pharmacological mechanisms of Tonifying-Qi and activating-blood Chinese medicine and CCM which have the function of anti-CIRI. Our goal is to provide effective reference for further researches on the cerebral protection of related TCMs or compounds and their clinical application.
Progression of the Wei-Qi-Ying-Xue Syndrome, Microcirculatory Disturbances, in Infectious Diseases and Treatment with Traditional Chinese Medicine
Authors: Han Jing-Yan , Li Quan , Pan Chun-Shui , Sun Kai , Fan Jing-Yu
Published: June 2022

Lipopolysaccharide (LPS)-induced endotoxemia is a critical condition that initiates microcirculatory disturbance and may progress to multiple organ failure that threatens the lives of millions of people around the world each year. The pathology of endotoxemia involves multiple insults mediated by a range of signaling pathways. Multitarget management is required to relieve endotoxemia. Traditional Chinese medicine (TCM) is a type of therapeutic that commonly contains numerous components and, thus, exhibits multitarget potential. More importantly, some TCM formulas have been proposed and used for effective treatment of endotoxemia-like diseases. In the past 20 years, an increasing number of studies have explored the effects and mechanisms of these formulas and their major bioactive components on microcirculatory disturbance and organ injury caused by LPS. The results obtained thus far provide support for the clinical use of TCM and shed light on the underlying mechanisms.
Danhong Injection Improves Elective Percutaneous Coronary Intervention in UA Patients with Blood Stasis Syndrome Revealed by Perioperative Metabolomics
Authors: Niu Qian , Xing Wen-Long , Wang Yu-Tong , Zhu Yan , Liu Hong-Xu
Published: June 2022

Objective:

To observe the effect of Danhong injection (DHI) on perioperative metabolomics of unstable angina pectoris (UA) with blood stasis syndrome.

Materials and Methods:

A prospective, randomized, controlled, and single-blind clinical trial was conducted. Sixty-one UA patients with traditional Chinese medicine blood stasis syndrome undergoing elective percutaneous coronary intervention (PCI) were randomly divided into the Danhong and control groups, and 10 healthy volunteers were included as baseline. The Danhong group received western medicine + DHI treatment, while the control group received western medicine + saline. Nontargeted metabolomics was used to analyze the serum metabolites of healthy volunteers in the Danhong and control groups before and 5 days after PCI.

Results:

Before treatment, there was no significant difference in serum metabolites between the Danhong and control groups, but there was a significant difference between the two groups and the healthy group. Differential metabolites were clustered mainly in glycerophospholipid, sphingolipid, purine, and amino acid groups, which were generated in their metabolic pathways. After 5 days of PCI, the profiles of serum metabolites were significantly closer between the Danhong-or control-treated groups and that of the healthy group. Furthermore, DHI treatment converted the serum metabolite profile more to that of the healthy group than the control treatment.

Conclusion:

The beneficial effect of DHI on patients with unstable angina is reflected at the level of serum metabolic biomarkers.
The ‘lost’ islands of Cardigan Bay, Wales, UK: insights into the post-glacial evolution of some Celtic coasts of northwest Europe
Authors: Haslett Simon K. , Willis David
Published: June 2022

A 13th –14th-century map held in the Bodleian Library (the Gough Map and the oldest map of Great Britain) shows two ‘lost’ islands in Cardigan Bay offshore west Wales, United Kingdom. This study investigates historical sources, alongside geological and bathymetric evidence, and proposes a model of post-glacial coastal evolution that provides an explanation for the ‘lost’ islands and a hypothetical framework for future research: (1) during the Pleistocene, Irish Sea ice occupied the area from the north and west, and Welsh ice from the east, (2) a landscape of unconsolidated Pleistocene deposits developed seaward of a relict pre-Quaternary cliffline with a land surface up to ca. 30 m above present sea-level, (3) erosion proceeded along the lines of a template provided by a retreating shoreline affected by Holocene sea-level rise, shore-normal rivers, and surface run-off from the relict cliffline and interfluves, (4) dissection established islands occupying cores of the depositional landscape, and (5) continued down-wearing, marginal erosion and marine inundation(s) removed the two remaining islands by the 16th century. Literary evidence and folklore traditions provide support in that Cardigan Bay is associated with the ‘lost’ lowland of Cantre’r Gwaelod. The model offers potential for further understanding post-glacial evolution of similar lowlands along northwest European coastlines.
Radiografía del universo sonoro en los estudios de comunicación en España la aplicación del pódcast en el aula
Authors: Olmedo Salar Silvia , López Villafranca Paloma , Muñoz Cámara Emilio
Published: June 2022

Introducción: la revolución del audio es un hecho que se constata actualmente con la expansión de productos sonoros a través del formato pódcast y la aparición de nuevos dispositivos tecnológicos como los altavoces inteligentes que incentivan su crecimiento. Ante esta escenario, este trabajo se centra en cómo se está trasladando esta situación al aula y en concreto a los estudios del Grado en Periodismo y de Comunicación Audiovisual en una realidad comunicativa en constante transformación. Metodología: este trabajo aplica una investigación con enfoque multi-metodológico y análisis cualitativo y cuantitativo, basada en la recopilación de datos a través de las guías docentes de los estudios de Periodismo y de Comunicación Audiovisual de 20 universidades españolas  y del aporte de docentes sobre el fenómeno del pódcasting y su uso en el aula. Resultados: el análisis determina que los planes de estudio de los Grados estudiados de la muestra requieren de una reformulación que permita recoger la rápida y revolucionaria evolución del medio radiofónico y sus productos de audio así como que el pódcast empieza a incorporarse en la planificación docente. Conclusiones: las principales conclusiones ratifican los resultados de la investigación y  evidencia que el pódcast todavía no figura como formato relevante, a pesar de existir un uso no contado del mismo, pero se observa un deseo explícito por hacerlo aliado de la necesaria transformación en el aula dada su aceptación y cada vez un mayor consumo por parte del estudiantado.
Complementary Feeding Recommendations for A Healthy Future Generation
Authors: Yonar Gizem , Özturan Şirin Ayçıl
Published: June 2022

World Health Organization data remark that 144 million children under the age of 5 are stunted by age. In Turkish society, the high weakness and stunting rates, especially among children aged 6-8 months, are an indication that complementary nutrition practices are not given enough importance in our country. Therefore, this review, it is aimed to emphasize the importance of complementary feeding in terms of the risk of malnutrition among children and to give an example of current complementary feeding practices. It is stated that at the beginning of the 5th month, infants neuromuscular development, digestive system, and renal solute load are suitable for complementary feeding. In addition to breast milk, complementary foods should include cereals, roots and tubers, legumes, nuts and seeds, dairy, meats, eggs, vegetables and fruits rich in vitamin A. Foods with allergy risk, such as eggs and peanuts should be tried for infants between 4 and 6 months. Along with breast milk, it is stated that 6-8-month olds are fed 2 or 3 times a day, and 9-11-months-old fed 3 or 4 times a day and should be paid attention to hunger and satiety signals. Complementary feeding should be started at 2 or 3 teaspoons and be increased considerably and transition should be made from pureed foods lumpy foods, finger foods and then chopped family foods until they are 12 months old. During the first year, vitamin D and iron micronutrient supplementation should be followed. It is recommended for infants to sip water instead of sugary drinks like fruit juices at meals and to introduce gluten to infants between 4 and 12 months. It is warned not to add sugar, salt and honey to the complementary feeding. To reduce the risk of malnutrition among children in Türkiye, complementary feeding should be given due significance.
Asynchronous wreath product and cascade decompositions for concurrent behaviours
Authors: Adsul Bharat , Gastin Paul , Sarkar Saptarshi , Weil Pascal
Published: June 2022

We develop new algebraic tools to reason about concurrent behaviours modelled
as languages of Mazurkiewicz traces and asynchronous automata. These tools
reflect the distributed nature of traces and the underlying causality and
concurrency between events, and can be said to support true concurrency. They
generalize the tools that have been so efficient in understanding, classifying
and reasoning about word languages. In particular, we introduce an asynchronous
version of the wreath product operation and we describe the trace languages
recognized by such products (the so-called asynchronous wreath product
principle). We then propose a decomposition result for recognizable trace
languages, analogous to the Krohn-Rhodes theorem, and we prove this
decomposition result in the special case of acyclic architectures. Finally, we
introduce and analyze two distributed automata-theoretic operations. One, the
local cascade product, is a direct implementation of the asynchronous wreath
product operation. The other, global cascade sequences, although conceptually
and operationally similar to the local cascade product, translates to a more
complex asynchronous implementation which uses the gossip automaton of Mukund
and Sohoni. This leads to interesting applications to the characterization of
trace languages definable in first-order logic: they are accepted by a
restricted local cascade product of the gossip automaton and 2-state
asynchronous reset automata, and also by a global cascade sequence of 2-state
asynchronous reset automata. Over distributed alphabets for which the
asynchronous Krohn-Rhodes theorem holds, a local cascade product of such
automata is sufficient and this, in turn, leads to the identification of a
simple temporal logic which is expressively complete for such alphabets.
Protocolo para evitar robo de datos mediante encriptamiento de una red doméstica o de uso personal
Authors: Arce Briceño Juan Alonso
Published: June 2022

Este documento electrónico/digital está dirigido a toda clase de persona que esté interesada en informarse en el tema de ciberseguridad mediante el uso de encriptación, por lo que se explicará dos términos elementales que tendrán relevancia en el proyecto adjunto: ciberespacio y ciberseguridad. En adición a lo mencionado anteriormente, se implementan dos tipos de procesos de encriptación, los cuales se verán dirigidos hacia: redes privadas y domésticas. Por último, el autor ofrece una solución determinada según lo investigado de forma teórica lo cual serán los pasos ideales que todo individuo debe seguir para poseer un ambiente sin brechas de seguridad (protocolo de detección de intrusiones). En conclusión, se referirá a los resultados/conclusiones realizadas por parte del investigador, con el fin de que los lectores puedan tener una idea clara y concisa de lo aprendido por parte del escritor.
Higiene e información
Authors: Rojas Gamboa José Nelson
Published: June 2022

La información es la clave del desarrollo. La igualdad y el progreso de pueblos y comunidades depende de la integración activa de la educación en el empoderamiento de las personas. Days for Girls procura el bienestar emocional y material de menores en condiciones de subdesarrollo económico. Método: Entrevistas grupales desarrolladas sobre la ejecución de charlas formativas. Resultado: Motivar hábitos de salud responsable a partir de una formación equitativa requiere brindar herramientas en el ámbito educativo y económico. Conclusión: El proyecto de copas menstruales representa el derribamiento de tabúes culturales de fuerte arraigo en una sociedad ugandesa, profundamente patriarcal y alejada de los cánones del desarrollo occidental.
Muscle and Nerve Biopsy in Various Neuromuscular Disorders
Authors: Park Young-Eun , Shin Jin-Hong , Kim Dae-Seong
Published: June 2022

Muscle and nerve biopsy may be vital diagnostic tools in various neuromuscular disorders. Since these procedures are invasive, it matters to decide when to perform a biopsy, which muscle or nerve to be selected, and how to interpret the pathologies. This review addresses the indications, methods of biopsies, and also significant pathological findings frequently encountered in muscle and nerve pathology.
Machine Learning Analysis of RFID Technology Adoption Factors
Authors: M. Pavan Kumar  , A. Baradwaj  , K. Yashwant  , Ch. Vinay Kumar  , CH. Vijaya Kumar
Published: June 2022

This paper presents an approach grounded on radio frequence identification(
RFID) and machine literacy for impurity seeing of food particulars and drinks similar as
soft drinks, alcohol, baby formula milk, etc. We employ sticker- type inkjet publishedultrahigh-frequency( UHF) RFID markers for impurity seeing trial. The RFID label antenna
was mounted on pure as well as defiled food products with known adulterant volume. The
entered signal strength index( RSSI), as well as the phase of the backscattered signal from
the RFID label mounted on the food item, are measured using the Tagformance Pro
setup. We used a machine- learning algorithm XGBoost for farther training of the model
and perfecting the delicacy of seeing, which is about 90. thus, this exploration study paves
a way for ubiquitous impurity/ content seeing using RFID and machine literacy
technologies that can enlighten their druggies about the health enterprises and safety of
their food.
Tensiones entre “razón colonial” y saberes situados originarios
Authors: Mazzi Huaycucho Víctor
Published: June 2022

Se introduce una definición sobre “razón colonial” como discurso enmascarado sobre la percepción de un hecho histórico: la dominación colonial que afectó y afecta la situación de los pueblos originarios y los instala como “sujetos” bajo condición de inferioridad cultural. Deslinda con los supuestos fundamentos de “superioridad cultural” emitidos desde una perspectiva colonial que impone una condición de subordinación para los pueblos originarios, situación que es confrontada por el saber situado, representado por los sistemas comunicativos originarios. Expone la condición de los saberes situados, registrados durante las primeras décadas de la administración colonial: sistemas comunicativos, registro en tocapus, quipus, yupay (‘contar’), hampiy (‘curar’) y Hanan Pacha (‘astronomía’). Propone situar los saberes originarios como discurso legitimador para el análisis de los procesos que afectaron y afectan a nuestros pueblos originarios.
Assessment of the Contamination of Baghdad Soils with Lead Element
Authors: Fadhel Mena Amer , Abdulhussein Firas Mudhafar
Published: June 2022

The present study aims to study the content and spatial distribution of lead (Pb) contamination in the soils of some Baghdad cities (Middle of Iraq). Twenty soil samples were randomly collected from different land-use in the studied area at a depth between 5 to 30 cm. Ten samples are collected from Al-Rissafa side areas (Adhamiya, Al-Wazeeria (Battery Manufacturer), Shikh Omer, Ziyouna, Karada, Shaab, Sadr city, Al-Za’franiya, Al-Dora expressway, and Alselikh ) and other ten samples are collected from Al-Krakh side areas Al-Dora, Al-Masafi junction, Al-Dora, Sayidia, Al-Salam university college, Al-Bayaa (Industrial District), Jehad, Amirya, Abu Ghraib, Al-hurriya, and Kadhimiya. The soil samples have been analyzed for the lead (Pb) with the utilization of the X-Ray Fluorescence. Based on the results, there is a notable difference in the concentration of Pb compared with the national and international permissible limits. The mean concentrations of Pb are 19507.5, 12.8, 2.2 mg/kg for industrial, roadside, and agricultural respectively and <1 for commercial, residential, and waste dumping sites. The high Pb concentration in the soils has been related to anthropogenic activities. Further, the spatial analysis map showed the high concentration of Pb distribution in the Al-Rissafa side of Baghdad city. The geoaccumulation factor and contamination factor indicate that all the soil samples are uncontaminated except the industrial sites are very high contamination with Pb. Also, by calculating the potential ecological risk, It has been found there is a very high ecological risk in the industrial sites, while a low ecological risk in other sites in the study area. The results showed that the average concentration of Pb in soil was greater than the global soil average.
Expeditions of the Russian Museum to the White Sea Karelia (1958–2021)
Authors: Антропова И.А.
Published: June 2022

Статья посвящена более чем шестидесятилетней истории изучения Беломорской Карелии сотрудниками Русского музея. Приводятся основные этапы экспедиционных исследований начиная с 1950-х годов. Их целью было общее обследование территории, выявление сохранившихся памятников старины и вывоз наиболее ценных и пострадавших из них в Ленинград. Дается описание наиболее интересных находок: икон, книг, поклонных крестов, в том числе деревянного резного Распятия из Муезерского монастыря. Характеризуются методы работы с найденными артефактами: идентификация древесины, рентгенографирование и съемка в УФ-лучах; анализ химического состава авторского и поновительского живописных слоев и металлизированного покрытия икон. Отмечается, что благодаря появлению современных технологий проводимая работа выходит на новый уровень исследований.

The article is devoted to the more than 60 years of history of the study of the White Sea Karelia by the employees of the Russian Museum. The main stages of expeditionary research, starting from the 1950s, are given, which aimed at a general survey of the territory, identifying the surviving monuments of antiquity and exporting the most valuable and affected of them to Leningrad. The author gives a description of the most interesting finds: icons, books, worship crosses, including a wooden carved Crucifixion from the Muezersky Monastery. Such methods of working with found artifacts as wood identification, radiography and shooting in ultraviolet rays, analysis of the chemical composition of author's and innovative painting layers and metallized coating of icons are characterized. It is noted that in connection with the advent of modern technologies, the ongoing work is reaching a new level of research.
An icon within a tradition: “Fatherland” with 17 plot stamps from the collection of iconography of the Vetka Museum
Authors: Афанасьева О.В.
Published: June 2022

В статье представлен анализ одной из икон богатого собрания Ветковского музея старообрядчества и белорусских традиций (Республика Беларусь). Высказывается предположение о возможном круге авторов данного произведения, дается общая характеристика иконы, подробно анализируется центральная часть и все семнадцать клейм. Показывается, что исполнитель или заказчик иконы стремится создать особый тип произведения — иконы-иконостаса, в котором находят свое отражение его интерес и достаточно глубокое погружение в догматику православного учения, причем в варианте аскетического и монашеско-иноческого проявления. Заметны поиски воззрений, отраженных в конкретном церковном собрании старообрядцев-ветковцев, включенных в традиционный уклад и устоявшуюся систему верований. В анализе применяются метод архивных изысканий, историко-искусствоведческий анализ, исследование воплощения вопросов православной догматики в системе художественно выразительных средств.

The article presents an analysis of one of the icons from the rich collection of the Vetka museum of Old Believers and Belarusian traditions (Republic of Belarus). The author suggests a possible circle of authors of this icon, gives a general description of the icon, analyzes in detail the central part and all seventeen plot stamps. The study shows that the performer or customer of the icon seeks to create a special type of work — an iconostasis icon, which reflects his interest and sufficiently deep immersion in the dogmatics of Orthodox teaching, and in a variant of ascetic and monastic-monastic manifestations. There is a noticeable search for views reflected in a particular church meeting of Old Believers-Vetkovites, included in the traditional way of life and an established system of beliefs. The analysis uses the method of archival research, historical and art criticism analysis, the study of the questions of Orthodox dogmatics in the system of artistic means of expression.
From the history of the study of icons of the 18th – early 20th century in the existing churches of the Luhansk region
Authors: Борщенко Л.М.
Published: June 2022

В статье рассматриваются результаты проведенного сотрудниками Луганского художественного музея научного исследования иконописных памятников церковного искусства конца XVIII – начала ХХ веков на Луганщине. Дана краткая историческая картина развития иконописания в крае. Указаны основные храмы, в которых сосредоточены сохранившиеся до наших дней старинные иконы. Даны описания наиболее выдающихся из них. Выделены две большие группы исследуемых икон: писаные для церквей и небольшие иконы для домашнего богослужения. В каждой из групп выделяется своя иерархия по уровню профессиональной подготовки иконописцев.

The article examines the results of a scientific study by employees of the Luhansk Art Museum of icon-painting monuments of church art of the late 18th – early 20th centuries in the Luhansk region. The author gives a brief historical picture of the development of icon painting in the region. The study indicates the main temples in which the ancient icons that have preserved to this day are concentrated, describes the most prominent of them. The researcher distinguishes two large groups of studied icons: painted for churches and small icons for home worship. Each of the groups has its own hierarchy in terms of the level of professional training of icon painters.