bluuebunny/crossref_metadata_2025 huggingface dataset:
Normalizing Telemonitoring in Nurse-Led Care Models for Complex Chronic Patient Populations: Case Study
Authors: Gordon Kayleigh , Dainty Katie N , Steele Gray Carolyn , DeLacy Jane , Shah Amika , Seto Emily
Published: March 2022

Background

The implementation of telemonitoring (TM) has been successful in terms of the overall feasibility and adoption in single disease care models. However, a lack of available research focused on nurse-led implementations of TM that targets patients with multiple and complex chronic conditions (CCC) hinders the scale and spread to these patient populations. In particular, little is known about the clinical perspective on the implementation of TM for patients with CCC in outpatient care.

Objective

This study aims to better understand the perspective of the clinical team (both frontline clinicians and those in administrative positions) on the implementation and normalization of TM for complex patients in a nurse-led clinic model.

Methods

A pragmatic, 6-month implementation study was conducted to embed multicondition TM, including heart failure, hypertension, and diabetes, into an integrated nurse-led model of care. Throughout the study, clinical team members were observed, and a chart review was conducted of the care provided during this time. At the end of the study, clinical team members participated in qualitative interviews and completed the adapted Normalization Measure Development questionnaires. The Normalization Process Theory guided the deductive data analysis.

Results

Overall, 9 team members participated in the study as part of a larger feasibility study of the TM program, of which 26 patients were enrolled. Team members had a shared understanding of the purpose and value of TM as an intervention embedded within their practice to meet the diverse needs of their patients with CCC. TM aligned well with existing chronic care practices in several ways, yet it changed the process of care delivery (ie, interactional workability subconstruct). Effective TM normalization in nurse-led care requires rethinking of clinical workflows to incorporate TM, relationship development between the clinicians and their patients, communication with the interdisciplinary team, and frequent clinical care oversight. This was captured well through the subconstructs of skill set workability, relational integration, and contextual integration of the Normalization Process Theory.

Conclusions

Clinicians successfully adopted TM into their everyday practice such that some providers felt their role would be significantly and negatively affected without TM. This study demonstrated that smartphone-based TM systems complemented the routine and challenging clinical work caring for patients with CCC in an integrated nurse-led care model.
The Association Between Actigraphy-Derived Behavioral Clusters and Self-Reported Fatigue in Persons With Multiple Sclerosis: Cross-sectional Study (Preprint)
Authors: Gulde Philipp , Rieckmann Peter
Published: March 2022

BACKGROUND

Persons with multiple sclerosis frequently report increased levels of fatigue and fatigability. However, behavioral surrogates that are strongly associated with self-reports are lacking, which limits research and treatment.

OBJECTIVE

The aim of this study was to derive distinct behavioral syndromes that are reflected by self-reports concerning fatigue and fatigability.

METHODS

We collected actigraphic data of 30 persons with multiple sclerosis over a period of 1 week during an inpatient stay at a neurorehabilitation facility. Further, participants completed the German fatigue severity scale. A principal component analysis of actigraphic parameters was performed to extract the latent component levels of behaviors that reflect fatigue (quantity of activity) and fatigability (fragmentation of activity). The resulting components were used in a cluster analysis.

RESULTS

Analyses suggested 3 clusters, one with high activity (d=0.65-1.57) and low clinical disability levels (d=0.91-1.39), one with high levels of sedentary behavior (d=1.06-1.58), and one with strong activity fragmentation (d=1.39-1.94). The cluster with high levels of sedentary behavior further revealed strong differences from the other clusters concerning participants’ reported levels of fatigue (d=0.99-1.28).

CONCLUSIONS

Cluster analysis data proved to be feasible to meaningfully differentiate between different behavioral syndromes. Self-reports reflected the different behavioral syndromes strongly. Testing of additional domains (eg, volition or processing speed) and assessments during everyday life seem warranted to better understand the origins of reported fatigue symptomatology.
Vascular Aging Estimation Based on Artificial Neural Network Using Photoplethysmogram Waveform Decomposition: Retrospective Cohort Study (Preprint)
Authors: Park Junyung , Shin Hangsik
Published: March 2022

BACKGROUND

For the noninvasive assessment of arterial stiffness, a well-known indicator of arterial aging, various features based on the photoplethysmogram and regression methods have been proposed. However, whether because of the existing characteristics not accurately reflecting the characteristics of the incident and reflected waveforms of the photoplethysmogram or because of the lack of expressive power of the regression model, a reliable arterial stiffness assessment technique based on a single photoplethysmogram has not yet been proposed.

OBJECTIVE

The purpose of this study is to discover highly correlated features from the incident and reflected waves decomposed from a photoplethysmogram waveform and to develop an artificial neural network-based regression model for the assessment of vascular aging using newly derived features.

METHODS

We obtained photoplethysmograms from 757 participants. All recorded photoplethysmograms were segmented for each beat, and each waveform was decomposed into incident and reflected waves by the Gaussian mixture model. The 26 basic features and 52 combined features were defined from the morphological characteristics of the incident and reflected waves. The regression model of the artificial neural network was developed using the defined features.

RESULTS

In correlation analysis, the features from the amplitude of the reflected wave and the skewness of the photoplethysmogram showed a relatively strong correlation with the participant’s real age. In the estimation of real age, the artificial neural network model showed 10.0 years of root mean square error. Its estimated age and real age had a strong correlation of 0.63 (P<.001).

CONCLUSIONS

This study proved that the features defined from the reflected wave and skewness of the photoplethysmogram are useful to assess vascular aging. Moreover, the regression model of artificial neural network using these features shows the feasibility for the estimation of vascular aging.

CLINICALTRIAL

Data acquisition was conducted after obtaining approval from the Asan Medical Center (Seoul Republic of Korea) Research Ethics Committee (IRB No.2015-0104).
A Platform (Authorships.org) for the Objective Qualification and Order of Academic Authorship in Medical and Science Journals: Development and Evaluation Study Using the Design Science Research Methodology (Preprint)
Authors: Raptis Dimitri Aristotle , Raptis Aristotle , Tinguely Pascale ,   Authorships.org Collaborative
Published: March 2022

BACKGROUND

The qualification and order of authorship in scientific manuscripts are the main disputes in collaborative research work.

OBJECTIVE

The aim of this project was to develop an open-access web-based platform for objective decision-making of authorship qualification and order in medical and science journals.

METHODS

The design science process methodology was used to develop suitable software for authorship qualification and order. The first part of the software was designed to differentiate between qualification for authorship versus acknowledgment, using items of the recommendations of the International Committee of Medical Journal Editors. The second part addressed the order of authorship, using the analytical hierarchy process for objective multiple criteria decision-making and ranking. The platform was evaluated qualitatively (n=30) and quantitatively (n=18) using a dedicated questionnaire, by an international panel of medical and biomedical professionals and research collaborators worldwide.

RESULTS

Authorships.org represents an open-access software compatible with all major platforms and web browsers. Software usability and output were evaluated and presented for 3 existing clinical and biomedical research studies. All 18 international evaluators felt that the Authorships.org platform was easy to use or remained neutral. Moreover, 59% (n=10) were satisfied with the software output results while the rest were unsure, 59% (n=10) would definitely use it for future projects while 41% (n=7) would consider it, 94% (n=16) felt it may prove useful to eliminate disputes regarding authorship, 82% (n=14) felt that it should become mandatory for manuscript submission to journals, and 53% (n=9) raised concerns regarding the potential unethical use of the software as a tool.

CONCLUSIONS

Authorships.org allows transparent evaluation of authorship qualification and order in academic medical and science journals. Objectified proof of authorship contributions may become mandatory during manuscript submission in high-quality academic journals.
Patterns of Daily Cigarette and E-cigarette Use Among United States Youth and Young Adults: Insights from the Truth Longitudinal Cohort between 2018 and 2019 (Preprint)
Authors: Hair Elizabeth , Do Elizabeth K. , Liu Michael (Shiyang) , Tulsiani Shreya , Suleta Katie , Vallone Donna , Pierce John
Published: March 2022

BACKGROUND

Prior to the introduction of JUUL, a high nicotine e-cigarette product that gained market predominance in 2017, adolescents who experimented with e-cigarettes mainly progressed to daily cigarette use. It is unknown how patterns of tobacco product use have changed since high nicotine e-cigarette products have gained market predominance.

OBJECTIVE

This longitudinal study examines temporal patterns of daily tobacco product use among ever users from the Truth Longitudinal Cohort (TLC).

METHODS

The analytic sample (N=5274) includes individuals aged 15-36 years, residing in the United States, who had ever used any tobacco product at Wave 7 (collected between February – May 2018) and provided information on tobacco use at Wave 9 (collected between November – December 2019). Respondents were asked to report on their use of e-cigarettes, cigarettes, and other combustible tobacco products (e.g., little cigars, cigarillos, cigars, hookah, smokeless tobacco, pipe tobacco) in the past 30 days. Use of any tobacco product on at least 25 days of the past 30 days was categorized as daily use. To determine temporal patterns of daily tobacco product use, variance estimates and 95% confidence intervals were calculated using STATA (Version 15.1). Survey weights were applied to obtain statistically valid estimates from longitudinal analyses.

RESULTS

During the 23-month observation period, there was an 1.9% increase in the prevalence of daily tobacco use, from 11.4% to 13.3%. Overall, daily cigarette use decreased from 6.7% (95% CI: 6.0 – 7.4) to 6.3% (95% CI: 5.7 – 7.0), while daily e-cigarette use increased from 3.3% (95% CI: 2.8 – 3.8) to 5.3% (95% CI: 4.8 – 6.0). A large proportion of daily tobacco product users used a single product exclusively. Among daily tobacco users, there was considerable stability of tobacco product use over time. Specifically, 63.9% (95% CI: 58.7 – 68.9) of daily cigarette smokers, 58.7% (95% CI: 51.0 – 66.2) of daily e-cigarette vapers, and 26.3% (95% CI: 9.2 – 51.2) of daily dual users stayed with their primary tobacco product. There was also some evidence of switching, as 7.4% (95% CI: 4.9 – 10.6) of daily cigarette smokers became daily e-cigarette vapers and 3.5% (95% CI: 1.3 – 7.4) of daily e-cigarette vapers became daily cigarette smokers.

CONCLUSIONS

Results demonstrate that although most daily tobacco users are likely to continue using their primary product over time, some daily users of combustible tobacco products will transition to daily e-cigarette use. Thus, policies and public education focused on reducing nicotine use are essential for implementing change in the trajectory of the nicotine addiction epidemic among youth and young adults.
Developing and Testing a Protocol for Managing Cardiopulmonary Resuscitation of Patients with Suspected or Confirmed COVID-19: In Situ Simulation Study (Preprint)
Authors: Sowan Azizeh , Heins Jenny , Dayton Christopher , Scherer Elizabeth , Tam Wing Sun , Saikumar Haritha
Published: March 2022

BACKGROUND

Resuscitating patients with suspected or confirmed COVID-19 imposes unique challenges to organizations and code blue teams. Studies that applied the American Heart Association (AHA) COVID-19–related Interim Resuscitation Guideline and similar European guidelines are scarce.

OBJECTIVE

This study aimed to develop and test a cardiopulmonary resuscitation protocol based on the AHA COVID-19–related Interim Resuscitation Guideline.

METHODS

The study was conducted as an in situ simulation in a medical intensive care unit. The COVID-19 cardiopulmonary resuscitation protocol was created and validated by 11 health care team members and tested using 4 simulation sessions where 46 code blue team members participated. During the simulation, we observed role clarity, the effectiveness of communication, team dynamics, infection control measures, and the availability of essential supplies and equipment.

RESULTS

The main issues identified in each simulation session were debriefed to the code blue teams and used to further revise the protocol. These include the assignment of tasks, availability of equipment and supplies, and failure of communication between the in-room and out-of-room teams. Solutions included changes in the placement of team members and roles and responsibilities; the creation of an isolation code medication package, a respiratory therapy kit, and an isolation code blue bag; and the use of two-way radios and N-95 masks with eye goggles to enhance communication between the teams.

CONCLUSIONS

This study shed light on the challenges to implement the AHA COVID-19–related Interim Resuscitation Guideline. The in situ simulation was an effective approach for rapid training, identifying unreliable equipment and ineffective and inefficient workflow, and managing the complexity of the physical environment.
Сучасний підхід до лікування інсульту. Національні рекомендації
Authors: Zharikova Julia
Published: March 2022

No abstract
Гіпертрофічний пахіменінгіт: клінічний випадок і огляд літератури
Authors: Ponomarev V.V. , Rakots T.A.
Published: March 2022

У статті наведений клінічний розбір пацієнта з недиференційованим гранулематозним системним васкулітом із переважним ураженням легень і його ускладненням у вигляді хронічного гіпертрофічного конвекситального пахіменінгіту грибкової (Candida) етіології. Проведена диференційна діагностика з гранулематозним поліангіїтом. Наведені сучасні літературні дані з критеріїв діагностики й методів лікування цієї рідкої патології.
Діагностика і лікування астроцитоми: огляд літератури
Authors: Chaulagain Dipak , Smolanka Volodymyr , Smolanka Andriy
Published: March 2022

Астроцитома є досить поширеною формою пухлини головного мозку. Вона розвивається з астроцитів — зіркоподібних клітин, що утворюють «клейоподібну» або підтримуючу тканину. Астроцитоми класифікують за характером і тяжкістю. За даними Всесвітньої організації охорони здоров’я, виділяють I–IV ступені цих пухлин. Пілоцитарна астроцитома, астроцитома II ступеня, анапластична астроцитома і мультиформна гліобластома є найпоширенішими видами астроцитоми. Однак залежно від виду клінічні прояви і діагноз можуть змінюватися. Хірургічне лікування теж відрізняється залежно від типу астроцитоми. Мета цього дослідження: визначити основні характеристики різних форм астроцитоми, краще зрозуміти діагностику і терапію, а також провести пошук публікацій у базах даних NCBI, PubMed та Google Scholar. У статті наведено огляд лікування астроцитоми на основі її типу; результати значною мірою залежать від різних форм астроцитоми, можливості виконати тотальну резекцію і, нарешті, прогнозу. Знання типів астроцитоми і проявів може допомогти при хірургічному лікуванні. Ми також представили огляд літератури щодо типів і діагностики астроцитоми та оцінили іcнуючі хірургічні методи лікування та прогноз.
Класифікація мостових інфарктів
Authors: Prokopiv M.M. , Yevtushenko S.K. , Fartushna O.Ye.
Published: March 2022

Актуальність. Мостові інсульти є складними в діагностиці і, порівняно з півкульними інсультами, мають гірший прогноз та перебіг. Проте мало наукових праць опубліковано про класифікацію мостових інсультів. Ми прагнули надати місткий та короткий огляд наукової медичної літератури щодо класифікації мостових інсультів. Матеріали та методи. Проведено комплексний електронний пошук літератури у базах даних Scopus, Web of Science, MEDLINE, SciЕLО, PubMed, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RINC, а також у базах даних державних наукових бібліотек України, Європейського Союзу, Великобританії, США з метою виявлення наукових публікацій, у яких обговорювалася класифікація мостових інсультів. Результати. Наведено та обговорено огляд наукової медичної літератури про класифікацію мостових інсультів. Висновки. Ми надали докладний огляд класифікації мостових інсультів.
Клінічний досвід застосування комплексного засобу Трилумін при веденні пацієнтів, які перенесли коронавірусну хворобу COVID-19 і мають синдром хронічної втоми на тлі вторинного імунодефіциту
Authors: Vasylovskyy V.V. , Kosinov A.A. , Golubtsova M.V.
Published: March 2022

Актуальність. Встановлено, що COVID-19 найчастіше призводить до опосередкованих неврологічних пошкоджень: гіпоксичної травми головного мозку та імунообумовленого ураження ЦНС. Коронавірусна інфекція має доведені механізми шкідливого впливу на нервову систему та імунітет, провокує розвиток постковідного синдрому хронічної втоми. Мета: вивчити ефективність застосування імунокоригуючого засобу Трилумін в комплексній терапії пацієнтів, які перенесли коронавірусну хворобу COVID-19 і мають синдром хронічної втоми на тлі вторинного імунодефіциту. Матеріали та методи. Для оцінки ефективності комплексної терапії постковідного синдрому хронічної втоми на тлі вторинного імунодефіциту вивчали результати клінічних та імунологічних тестів, оцінку якості життя пацієнтів та провели статистичний аналіз. Результати. У динаміці спостереження саме у групі дослідження в точках моніторингу на 12-й та 22-й день відзначався більш виражений регрес клінічної симптоматики, спостерігалася повноцінна нормалізація показників імунограми, зокрема імунорегуляторного індексу, а також фіксувалися кращі показники якості життя хворих. Отримані результати ведення постковідного синдрому хронічної втоми на тлі вторинного імунодефіциту дозволяють обґрунтовано припустити, що додавання до схеми менеджменту цього захворювання імунокоригуючого компонента Трилуміну допомагає реалізувати програму комплексної реабілітації пацієнтів: призводить до зменшення інтенсивності клінічних проявів, нормалізації імунологічних показників, відновлення фізичної та розумової активності пацієнтів. Висновки. Додавання комплексного засобу Трилумін до алгоритму ведення пацієнтів з постковідним синдромом хронічної втоми призводить до нормалізації імунологічних показників, більш вираженої динаміки регресу клінічної симптоматики, відновлює якість життя пацієнтів. Трилумін може бути рекомендований для доповнення схеми менеджменту пацієнтів, які перенесли коронавірусну хворобу COVID-19 і мають синдром хронічної втоми на тлі вторинного імунодефіциту.
Леветирацетам — сучасне рішення проблеми епілепсії в нейропедіатричній практиці
Authors: Maryenko L.B. , Marienko K.M.
Published: March 2022

Леветирацетам — протиепілептичний препарат, що має принципово інший механізм дії серед усіх препаратів цієї групи. Дослідження in vitro показали, що леветирацетам зв’язується з глікопротеїном синаптичних везикул SV2A, що містяться в сірій речовині головного і спинного мозку. Таким чином, він впливає на внутрішньонейрональну концентрацію іонів Са2+, частково гальмуючи потік Са2+ через канали N-типу і знижуючи вивільнення кальцію з внутрішньонейрональних депо. Крім того, леветирацетам частково відновлює потоки через GABA- і гліцин-залежні канали, знижені цинком і β-карболінами. Завдяки цьому леветирацетам пригнічує надлишкову синхронізацію нейронів і реалізує протисудомний ефект. У нейропедіатричній практиці накопичені дані про те, що леветирацетам може призначатися як монотерапія для лікування вогнищевих нападів із переходом (або без нього) у двобічні тоніко-клонічні напади, а також як допоміжна терапія при міоклонічних нападах у пацієнтів із ювенільною міоклонічною та ідіопатичною генералізованою епілепсією. При цьому для леветирацетаму характерні швидке досягнення терапевтичного ефекту й хороша переносимість у дітей і підлітків, що доведено в багатьох рандомізованих клінічних дослідженнях.
Особливості лікування сенсоневральної приглухуватості судинного генезу та вікової втрати слуху
Authors: Trishchynska M.A. , Kononov O.Ye.
Published: March 2022

Сенсоневральна приглухуватість (СНП) (нейросенсорна, перцептивна) — форма зниження слуху аж до повної глухоти, що характеризується ураженням звукосприймаючого відділу слухового аналізатора. СНП має значну поширеність і велику кількість етіологічних факторів. Значна поширеність серцево-судинних захворювань пояснює велику частку пацієнтів із СНП судинного генезу. Вікова втрата слуху (пресбіакузис) є одним із найпоширеніших нейродегенеративних захворювань у розвинених країнах. Оскільки пресбіакузис невиліковний, рекомендується використовувати допоміжні засоби, щоб поліпшити чутність і полегшити спілкування для запобігання зниженню когнітивних функцій у людей похилого віку. Холіну альфосцерат, напівсинтетичне похідне фосфатидилхоліну, є попередником ацетилхоліну в головному мозку. Фармакологічний ефект Медотиліну обумовлений стимуляцією синтезу ацетилхоліну та фосфатидилхоліну (фосфоліпіду мембран), що покращує передачу сигналів холінергічних нейронів, еластичність мембран та функцію рецепторів.
Ефективна терапія тривожних, депресивних розладів та нейропатичного болю: новий погляд на проблему
Authors: Chistyk T.
Published: March 2022

Поширеність депресивних розладів у населення економічно розвинених країн Європи і США досягає 10 %, хоча б один епізод тривожних розладів реєструється у 12–27 % населення Європи. У пацієнтів з нейропатичним болем тривожні і депресивні розлади зустрічаються в 2–3 рази частіше, ніж у загальній популяції. Це пояснюється наявністю загальних механізмів формування хронічного болю, депресії і тривоги, в основі яких лежить дефіцит серотоніну і норадреналіну. Дулоксетин пригнічує зворотний захват серотоніну і норадреналіну, тим самим підвищує серотонінергічну і норадренергічну нейротрансмісію в центральній нервовій системі. Унаслідок цього відбувається підвищення функціональної активності низхідної системи пригнічення болю та порогу больової чутливості, що забезпечує ефективну знеболювальну дію препарату. Дулоксетин рекомендується NICE-2020 як препарат першої лінії для лікування діабетичного периферичного нейропатичного болю з уніполярною депресією або без неї, а також для літніх пацієнтів з депресією із супутніми кардіоваскулярними захворюваннями. У рекомендаціях Німецького товариства неврологів дулоксетин поряд з прегабаліном, габапентином і амітриптиліном є препаратом першої лінії в лікуванні нейропатичного болю, депресії і генералізованого тривожного розладу. Ефективність і безпека дулоксетину у лікуванні літніх пацієнтів з депресією і болем, нейропатичним болем і великим депресивним розладом доведені в численних рандомізованих дослідженнях.
A COMPARATIVE STUDY OF EFFICACY ON GLYCEMIC CONTROL BY GLIMEPIRIDE VERSUS TENELIGLIPTIN AS AN ADD ON TO METFORMIN THERAPY IN TYPE 2 DIABETES MELLITUS PATIENTS
Authors: BOMMINENI SASHIDHAR REDDY , SHRAVANI P. , SHYAM J. , ALEKHYA M. , SRIKANTH B.
Published: March 2022

Objective: In our study, the objective was to evaluate the effectiveness of glycemic control of Glimepiride versus Teneligliptin for 2nd-line therapy in combination with Metformin in T2DM patients.

Methods: A Randomized, Observational, Prospective study has been conducted in outpatient and inpatient departments of General Medicine in RVM Hospital (Laxmakkapally, Mulugu, Siddipet, Telangana). A total of 100 patients with T2DM were recruited in our study in which 50 patients were in Group A (Metformin-Glimepiride) and the other 50 patients were in Group B (Metformin-Teneligliptin). The comparative assessment of efficacy was conducted using glycemic parameters such as FBS, PPBG and HbA1c to interpret the results.

Results: The mean difference values of HbA1c pre-treatment and post-treatment of Group A were calculated as 1.47 and of Group B was 0.83. The mean difference values FBS pre-treatment and post-treatment of Group A were found to be 56.96 and Group B was 29.62. The PLBS mean difference at Pre-treatment and Post-treatment of Group A and Group B was obtained to be 115.8 and 52.58, respectively.

Conclusion: From the results obtained, we hereby conclude that, though there was no large difference between the lowering of HbA1c values by two Groups, the FBS and PLBS levels were diminished significantly by Group A (Metformin-Glimepiride) than Group B (Metformin Teneligliptin). Therefore, Glimepiride is considered to be more beneficial than Teneligliptin when combined with Metformin Monotherapy.
PROTECTIVE FEATURES OF LOBOPHORA VARIEGATA METHANOLIC EXTRACT (LVME) ON COGNITIVE BEHAVIOUR AND REDOX HOMEOSTASIS IN N-NITROSODIETHYLAMINE TREATED DROSOPHILA MELANOGASTER
Authors: AJITHA ADAIKKALM , SUBRAMANIAN PERUMAL
Published: March 2022

Objective: The protecting influence of methanolic extract of seaweed (Lobophora variegata) on cognitive as well as biochemical indices in N-Nitrosodiethylamine (NDEA, a potent carcinogen) treated Drosophila melanogaster is evaluated.

Methods: In this study, Flies are divided into four groups; group 1–(control), group 2-flies were treated with 0.01% NDEA in food medium, group 3–with 0.01% NDEA and 0.01% Lobophora variegata methanolic extract (LVME) and group 4-with 0.01% LVME alone.

Results: Behavioural abnormalities (negative geotaxis, phototaxis, smell and taste chemotaxis, hygrotaxis and thermotaxis) were quantitatively deviated in NDEA treated flies compared to control but were tend to be normalized in LVME treated flies. The contents of protein carbonyl, thiobarbituric acid reactive substance (TBARS), protein thiol and lipid peroxides were noticeably augmented in NDEA treated flies than control flies and correspondingly tend to normalize in LVME treated groups. Further, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and reduced glutathione (GSH) were decreased in NDEA treated group and were significantly increased (p<0.05) in LVME treated groups.

Conclusion: It is well known that seaweed extracts contain numerous beneficial phytochemicals in abundantly. From our investigation, we found that the 0.01% LVME is efficient in reverting the abnormal behaviours and restoring the redox homeostasis of NDEA induced carcinogenesis in Drosophila melanogaster. Our investigation indicates that these phytochemicals could prevent the abnormalities in behaviour and redox homeostasis during carcinogenesis in D. melanogaster.
La apuesta por la infraestructura
Authors: Damonte Gerardo , Ulloa Astrid , Quiroga Manrique Catalina , López Minchán Ana Paula
Published: March 2022

Public and private policies typically consider the construction of infrastructure the most appropriate response to the problems of water scarcity and water disputes. However, infrastructure in itself not always is the solution. Why water infrastructure is not in itself a solution to water stress and scarcity? How does infrastructure construction deepen inequalities in access to water? This article answers these questions by arguing that water infrastructures respond to technical-political projects of territorial control located in areas of mining influence, rather than aiming to solve water access and supply problems. In doing so, they ended up deepening inequalities in local water access. This article compares infrastructures constructed in the context of large-scale mining projects in Espinar, Peru and La Guajira, Colombia. The information presented was collected following qualitative methods (semi-structured interviews and situated ethnographies). Likewise, the article systematizes secondary quantitative and qualitative data provided by government institutions related to water and mining, and the Environmental Impact Studies and web publications regarding the Tintaya-Antapaccay and Cerrejón mining projects.
Josip Šentija - tihi borac za hrvatski jezik
Authors: Bašić Nataša
Published: March 2022

U članku se raspravlja o prinosu novinara, leksikografa i publicista Josipa Šentije afirmaciji hrvatskoga književnoga jezika potporom Deklaraciji o nazivu i položaju hrvatskog književnog jezika i njezinom obranom od unitarnih jezičnopolitičkih nasrtaja; o suzbijanju pokušaja srpske jezične kolonizacije Radio Zagreba; o ubiranju prvih poslijedeklaracijskih plodova očitovanih u izmijenjenim jezičnim člancima u jugoslavenskim republičkim ustavima iz 1974.; o primjeni 138. jezičnoga članka Ustava SRH u trećem izdanju Opće enciklopedije Leksikografskoga zavoda; o suradnji s Miroslavom Krležom i središnjim uredništvom u izgradnji enciklopedijskoga stila i njegovanju hrvatskoga jezika. Na kraju se raščlanjuju njegova politička stajališta modernoga socijaldemokratskoga usmjerenja i jasne nacionalne sastavnice u kontekstu raspada Jugoslavije i stvaranja neovisne hrvatske države s naglaskom na hrvatsko-srpskim odnosima i velikosrpskom ekspanzionističkom programu utemeljenom dijelom na Karadžićevoj krilatici Srbi svi i svuda, u čijoj je osnovi neznanstveno polazište o isključivom srpstvu štokavštine.
The assessment of the integrated safety of Russian oil and gas enterprises
Authors: Gvozdev E. V.
Published: March 2022

Introduction. The article addresses the choice of a method used to analyze hierarchies and pairwise comparisons (hereinafter — MAH), that serve as a framework for an integrated corporate safety assessment methodology. Its application ensures the transformation of input information, obtained in the form of a characteristic description of an assessed event, into the resulting assessment that has a weighted numerical value.

Goals and objectives. The main purpose of the article is to obtain an assessment result in respect of the actions that are added to industrial and fire safety checklists applied to assure the integrated safety of an enterprise. A selected MAH is used to make pairwise comparisons of factors and alternatives. Values of local and global priorities can be determined for each element under study. Weighted coefficients, obtained in the form of local priorities, are related to the activities being checked, while global priorities are directly related to the services (structural units) that ensure the sustainable integrated security of an enterprise.

Methods. The authors provide a rationale for the choice of MAH, which allows itemizing the values demonstrating the intensity of influence of factors and break them down into components. At the stage of synthesizing the obtained analytical results with the help of MAH, the results obtained by expertise must be verified by determining the value of the expert consistency ratio to confirm the adequacy of the obtained result.

Results. The probability of influence of analyzed hazards, related to accidents and fires at the enterprises under consideration, was assessed as a function of their causes during the 7-year period under review. The article presents calculated coefficients of communication, impacts and influence made by specialists employed with respective services (structural units) on the industrial and fire safety subsystems that encompassed the integra­ted safety of an enterprise. The results of introducing correction factor g, whose dependence is expressed by final indicators of damage measured in economic (ruble) and social (human) losses, are presented.

Discussion. The article focuses on the fact that the sustainable operation of industrial enterprises depends on the reliability margin of integrated corporate safety, the maintenance of which requires particular resources (financial, material resources, as well as the time, needed for the personnel to eliminate any identified deviations, etc.). Given that the resources focused on the integrated safety assurance are limited, they cannot meet all requests made by the heads of services (departments), while highly risky targeted activities need more research.
The comparative evaluation of the criteria used to determine the critical values of the partial density of carbon monoxide as part of the calculation of time to the blocking of escape routes in case of a room fire
Authors: Puzach S. V. , Cherepanov R. A. , Akperov R. G.
Published: March 2022

Introduction. Critical values of the partial density of gas, the toxic dose or relative mass of carboxyhemoglobin in human blood serve as the criteria determining the time to the blocking of escape routes due to the presence of carbon monoxide. However, the comparative analysis of the effect produced by the selected criterion on the time to the blocking of escape routes due to the presence of this gas has not been conducted yet.

Goals and objectives. The purpose of the article is to compare the values of the time to the blocking of escape routes by carbon monoxide obtained using various methods of determining the critical values of the carbon monoxide density. Towards this end, experimental studies on combustion processes of various solid and liquid combustible substances and materials were conducted in a small-scale test unit, and calculations of the time to the blocking of escape routes with carbon monoxide were made on their basis.

Theoretical fundamentals. The amount of carbon monoxide, inhaled during a fire, is calculated using experimentally measured partial densities of CO and mathematical models designated for the calculation of the toxic dose of this gas and formation of carboxyhemoglobin in human blood.

Results and discussion. Experimental dependencies between the testing time and medium-volume densities of monoxide emitted during the combustion of the “low smoke” PVC cable sheathing, timber (pinewood), chocolate, transformer oil and vegetable oil are presented. The authors obtained theoretical dependencies between the toxic dose and mass concentration of carboxyhemoglobin in human blood, on the one hand, and the time for the combustible materials, analyzed in the article. It has been found that the values of time to the blocking of escape routes due to the presence of carbon monoxide may differ significantly depending on the method used to determine the critical values of the carbon monoxide density.

Conclusions. Standard methods, used to calculate the time to the blocking of escape routes due to the presence of carbon monoxide, employ the value of the critical partial density which may involve a substantial overestimation of the above time frame and the underestimation of the toxic effect produced on a person in the process of his/her evacuation. Therefore, it is necessary to apply all methods, discussed in the article, to select the minimum value of the above time frame.
Evaluation of the bearing capacity of socket contacts within the framework of a fire investigation
Authors: Nedobitkov A. I. , Abdeyev B. M.
Published: March 2022

Introduction. The data, provided in the article, demonstrate the relevance of the socket fire safety improvement in the course of operation. The purpose of the article is to develop a research-backed method of examining the socket contacts that feature high transient resistance or change in shape. The method can be subsequently used to identify causes of damages in a fire investigation.

Materials and methods. A JSM-6390LV scanning electron microscope with a module designated for the energy dispersive microanalysis is used in the research. The subjects of research are type C (EU Type C) and type F (EU Type F) sockets. The failure surfaces of socket contacts were analyzed without preliminary sample preparation.

Theoretical fundamentals (theory and calculations). A physical and mathematical model of the limit bearing capacity of socket contacts, similar to the real construction, has been developed. The model serves as the framework for a practical computational algorithm of the expert analysis of mechanical and geometrical characteristics. The solution is reduced to short calculation formulas, that can be used to evaluate the bearing capacity of so­cket contacts. The applicability of the developed mathematical model to fire investigations is proven in a specific ­example.

Results and discussion. The authors analyze cases of socket fires, caused by the loss of the bearing capacity of socket contacts in the process of operation. Photos of the oxide film on the contact surface and its elemental composition are provided in the article. The experimental data have proven that the fusion of contacts and the presence of an oxide film, featuring high specific resistivity, are a significant criminalistic evidence that helps to identify causes of fire.

Conclusions. The authors propose a method for the identification of the bearing capacity of socket contacts. The method can be used to determine if a subsequent fire is related to the socket ignition. The information, provided in the article, can be used by specialists in the course of an expert examination of socket contacts withdrawn from the site of the fire to identify the failure mechanisms and, ultimately, causes of fire.
Autoeficácia docente na educação inclusiva e características do contexto de ensino
Authors: Nina Karla , Ramos Edson Marcos Leal Soares , Ravagnani Luis Ricardo , Britto Gisele Maria Gomes , Pontes Fernando Augusto Ramos , Silva Simone Souza da Costa
Published: March 2022

O objetivo deste estudo foi descrever a associação da autoeficácia de professores em práticas educacionais inclusivas com variáveis do contexto de ensino e características dos docentes. Participaram 193 professores da educação básica, sendo 77,72 % do sexo feminino e 22,28 % do sexo masculino de escolas particulares, confessionais e públicas estaduais localizadas nos municípios de Belém e Castanhal, Pará, Brasil. Foram aplicados os instrumentos de caracterização e a escala de eficácia de professores em práticas educacionais inclusivas. As técnicas de análise de dados foram a análise fatorial e a análise de correspondência. Dentre os resultados encontrados, verificaram-se as associações entre as variáveis investigadas, o que sugere que ao julgar a própria capacidade em práticas educacionais inclusivas, o professor considera alguns fatores presentes no contexto e em sua trajetória docente. Espera-se que este estudo possa contribuir com o estímulo a formação continuada de professores no contexto inclusivo.
Habilidades de teoría de la mente y de comprensión de verbos mentalistas en niños con desarrollo evolutivo normativo
Authors: Muñoz Jimena , De Lorenzi Mikaela , Montoya-Rodríguez María M. , Quiroga Baquero Luis Alberto , Rendon Arango María Isabel , De Souza Franco Vanessa Augusta , Tomás Llerena Clementina , Vera Vallega María Macarena
Published: March 2022

El aprendizaje de habilidades de la teoría de la mente (ToM) se considera fundamental para garantizar un buen desempeño adaptativo en el contexto social dado que permite a las personas atribuir estados mentales a sí mismas y a otras, y así poder predecir el comportamiento de los demás. El objetivo del presente estudio consistió en analizar el desempeño en las tareas de ToM y en la comprensión de verbos mentalistas contextualizados en historias en niños con desarrollo normativo. Se utilizó una muestra de 41 niños con edades comprendidas entre 3 y 5 años con una metodología descriptiva. Los resultados muestran que el nivel 3 de ToM fue el que obtuvo menores niveles de logro. En relación con la prueba que evaluaba la comprensión de verbos mentalistas, los resultados más bajos se obtuvieron en aquella que hacía referencia al verbo saber. Los resultados encontrados sugieren que se aprenden primero verbos mentales referidos a deseos antes que a creencias, así como que los niveles de información defendidos por el modelo de ToM de Howlin et al. (1999) no parecerían estar secuenciados en niveles de complejidad.
BURKITT LYMPHOMA CAUSING ILEOCOLIC INTUSSUSCEPTION AND BOWEL OBSTRUCTION IN AN ADULT: A CASE REPORT
Authors:   Consorcio Hospital General Universitario de Valencia, Tárraga Soriano Jorge , Hernández Ramos Xaviera María ,   Consorcio Hospital General Universitario de Valencia, Villalba Ferrer Francisco ,   Consorcio Hospital General Universitario de Valencia, Castella Bataller Laura ,   Consorcio Hospital General Universitario de Valencia, Ismail Hamed Ali Mahmoud ,   Consorcio Hospital General Universitario de Valencia, Mulas Fernández Claudia ,   Consorcio Hospital General Universitario de Valencia
Published: March 2022

BURKITT’S LYMPHOMA CAUSING ILEOCECAL INTUSSUSCEPTION AND BOWEL OBSTRUCTION IN AN ADULT: A CASE REPORT INVAGINACIÓN ILEOCECAL Y OBSTRUCCIÓN INTESTINAL SECUNDARIAS A LINFOMA DE BURKITT EN UN ADULTO: A PROPÓSITO DE UN CASO Background. Burkitt's lymphoma is a rare and aggressive tumor that constitutes less than 5% of lymphomas. Intussusception is rare in adults, accounting for only 5% of occlusions. Case presentation. We present the case of a 33-year-old man with an ileocecal intussusception due to Burkitt's lymphoma. The rarity of this form of presentation is highlighted and a review is made of the current diagnosis and treatment. Conclusions. Intussusception due to Burkitt's lymphoma is an entity to consider in the differential diagnosis of intestinal obstruction in adults, although it is an extraordinarily rare finding. Key words: Burkitt’s lymphoma, intussusception, bowel obstruction.
Analisis potensi wisata dan strategi pengembangan daya tarik wisata pantai blue lagoon bali
Authors: Paramitha Anisa
Published: March 2022

Pemerintah Kabupaten Karangasem memiliki misi untuk menciptakan destinasi pariwisata yang berkualitas, berdaya saing, dan berkelanjutan melalui semangat kearifan lokal. Pantai Blue Lagoon merupakan salah satu destinasi wisata alam di Kabupaten Karangasem. Pantai Blue Lagoon belum dikelola dan dikembangkan menjadi produk wisata yang menarik. Penelitian ini bertujuan untuk menganalisis potensi wisata dan strategi pengembangan Pantai Blue Lagoon agar dapat memberikan dampak positif bagi lingkungan, sosial budaya, dan ekonomi masyarakat lokal di Desa Padangbai. Analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif dan analisis SWOT. Hasil penelitian ini mengidentifikasi potensi wisata Pantai Blue Lagoon dengan komponen 4A; atraksi, fasilitas, aksesibilitas, dan layanan tambahan. Strategi pengembangan yang dapat digunakan di kawasan Pantai Blue Lagoon sebagai destinasi wisata alam antara lain; pengembangan produk wisata minat khusus, pengembangan pemasaran, pengembangan lingkungan (fisik, sosial budaya, ekonomi) dan perencanaan pengelolaan Pantai Blue Lagoon.
Pemanfaatan kulit anggur sebagai bahan teh herbal
Authors: Putra I Putu Adi Pratama
Published: March 2022

Kabupaten Buleleng merupakan daerah penghasil buah anggur di Provinsi Bali. Kecamatan penghasil anggur di Kabupaten Buleleng terdapat di Kecamatan Seririt dan Banjar. Sejalan dengan meningkatnya jumlah penduduk dan daya beli masyarakat, maka kesadaran mengkonsumsi buah khususnya anggur juga meningkat. Hal ini memberi kesempatan dan peluang untuk meningkatkan produksi sehingga dapat juga meningkatkan pendapatan petani anggur, mendukung perkembangan industry pengolahan anggur serta mengurangi impor. Teh herbal merupakan salah satu produk minuman campuran teh dan tanaman herbal yang memiliki khasiat dalam membantu pengobatan suatu penyakit atau sebagai penyegar. Oleh karena itu penelitian ini dilakukan dengan memanfaatkan kulit buah anggur menjadi bahan dalam pembuatan teh herbal yang memiliki citarasa yang alami, pewarna alami dan dapat dijadikan fungsional karena mengandung vitamin C antioksidan yang dapat meningkatkan manfaat Kesehatan.
Integrasi chse (cleanliness, health, safety, environment sustainability) terhadap kepuasan dan loyalitas wisatawan domestik berkunjung ke green kubu café
Authors: Widhiarini Ni Made Ayu Natih
Published: March 2022

Penelitian ini bertujuan untuk menggali persepsi wisatawan domestik terhadap penerapan CHSE di Green Kubu Café, dan mengidentifikasi pengaruh penerapan protokol CHSE terhadap kepuasan dan loyalitas wisatawan domestik berkunjung ke Green Kubu Café. Penelitian ini termasuk penelitian verifikatif dengan pendekatan deskriptif kuantitatif menggunakan analisis deskriptif statistik dan Partial Least Square. Hasil penelitian ini menunjukan bahwa 1) Persepsi wisatawan domestik terhadap penerapan protokol CHSE di Green Kubu Café adalah baik, 2) Protokol CHSE secara keseluruhan berpengaruh positif namun tidak signifikan terhadap kepuasan dan loyalitas wisatawan domestik selama berkunjung ke Green Kubu Café.
Strategi pemasaran untuk meningkatkan tingkat hunian kamar di tengah pandemic covid-19 di alaya resort ubud
Authors: Saksiari Luh Made
Published: March 2022

Tujuan penelitian ini adalah mengidentifikasi potensi lingkungan internal dan eksternal serta menganalisis strategi yang tepat yang akan digunakan untuk meningkatkan tingkat hunian kamar di tengah pandemi COVID-19. Penelitian ini menggunakan data kualitatif berupa Bauran Pemasaran 7P dan data kuantitatif berupa hasil kuisioner yang digunakan untuk menentukan analisis SWOT dan analisis Triangulasi. Data primer diperoleh dari hasil wawancara, pemberian bobot dan rating untuk faktor-faktor IFAS, EFAS, sedangkan data sekunder diperoleh dari data statistic seperti three months forecast, history and forecast, cancelation report Pandemic Covid-19. Teknik pengumpulan menggunakan wawancara, observarsi partisifatif, wawancara tidak terstuktur, studi dokumentasi, kuesioner. Hasil penelitian menghasilkan Strategi pemasaran alternatif yang dihasilkan dari kaudran SWOT adalah titik sumbu X (internal)  8,6 dengan sumbu Y (eksternal) 10,6, sehingga koordinat sumbu (x,y) berada pada titik kuadran I, yang artinya berada disituasi yang menguntungkan, dimana memiliki peluang dan kekuatan sehingga peluang pasar yang besar dapat dimanfaatkan  secara optimal seperti memanfaatkan lokasi yang strategis, memanfaatkan café lokal yang berdampingan dengan hotel untuk sarana operasional seperti penyediaan breakfast, menambah daya tarik dengan menambahkan guest activity dan melakukan promosi mengenai kegiatan operasioal hotel selama pandemi dengan memanfaatkan teknologi digitalisasi untuk menarik tamu untuk berkunjung. Hasil analisa Triangulasi berdasarkan focus strategy serta hasil analisa kuadran SWOT menunjukkan perlu berfokus dalam memperbaharui website dengan promo-promo terbaru, melakukan promosi secara berkala melalui sosial media seperti instagram dan facebook, menambah benefit kepada tamu yang menginap, serta melakukan competitor analysis dengan menyesuaikan harga kompetitor dan memperbaharui publish rate supaya memiliki harga saing yang sesuai dengan kompetitronya.