bluuebunny/crossref_metadata_2025 huggingface dataset:
Closantel Retinal Toxicity: Case Report and Literature Review
Authors: Ghods Sepideh , Khalili Pour Elias , Riazi-Esfahani Hamid , Faghihi Hooshang , Inanloo Bahman
Published: May 2021

A 57-year-old shepherd was referred with a 2-week history of decreased visual acuity in both eyes. Optical coherence tomography (OCT) (Heidelberg Engineering GmbH, Heidelberg, Germany) revealed diffuse outer nuclear layer hyperreflectivity and indistinguishable external limiting membrane and ellipsoid zone. The patient announced to us that he took two 500 mg of closantel tablets (15.15 mg/kg) three days before the initiation of visual problems for sore throat as an antibiotic. Electroretinography displayed severely attenuated responses in both eyes. We decided to admit the patient with the presumed diagnosis of closantel retinal toxicity and treated him with intravenous methylprednisolone 1 g per day and intravenous erythropoietin 10000 IU twice a day, and reevaluation of the patient proved no change in his visual acuity on the third day of admission. Closantel is a veterinary drug with serious side effects in the human retina and central nervous system even in previously reported doses. Public awareness and appropriate drug labeling about its side effects could prevent accidental toxicity. OCT is a noninvasive and rapid diagnostic modality that should be done in suspected toxic retinopathy.
Evaluation of Exposure to Toluene and Xylene in Gasoline Station Workers
Authors: Geraldino Barbara R. , Nunes Rafaella F. N. , Gomes Juliana B. , da Poça Katia S. , Giardini Isabela , Silva Paula V. B. , Souza Helen P. , Otero Ubirani B. , Sarpa Marcia
Published: May 2021

The main volatile organic compounds found at gasoline stations are benzene, toluene, ethylbenzene, and xylene isomers (BTEX). They cause several harmful effects on human health. Regulatory Norm 7 (1978) provides that, in Brazil, biological monitoring of toluene and xylene is carried out by measuring the urinary metabolites hippuric acid (HA) and methylhippuric acid (MHA), respectively. The objective of this study was to assess the exposure to toluene and xylene and to identify related signs and symptoms in gasoline station workers. A cross-sectional epidemiological study was conducted with workers occupationally exposed to fuels. These gasoline station workers were divided into two groups: 94 workers exposed mainly by inhalation (convenience store workers (CSWs)) and 181 workers exposed by inhalation and dermal route (filling station attendants (FSAs)). A comparison group was formed by 119 workers not occupationally exposed to fuels (office workers (OWs)). Workers exposed to fuels had higher average levels of these exposure biomarkers (HA and MHA), which were also higher in convenience store workers than in filling station attendants. In addition, individuals exposed to the solvents present in gasoline had altered mood/depression, cramps, dizziness, drowsiness, headaches, irritability/nervousness, weakness, weight loss, and other symptoms more frequently and had higher urinary levels of HA and MHA compared to the comparison group. Gasoline station workers showed high levels of HA and MHA, reflecting high occupational exposure to the solvents toluene and xylene present in gasoline, demonstrating that changes in the current legislation and in the work environment are necessary to ensure better health protection for these workers.
Computed Tomography Imaging Agent Based on Gold Nanoparticles for Internal Iliac Artery Embolization after Endovascular Abdominal Aortic Repair and CCN3 Protection Mechanism
Authors: Pei Siying , Sun Yao , Fan Dongxu , Deng Shuhua , Mei Haoran , Wang Hanrui
Published: May 2021

Abdominal aortic aneurysm is more stressful and has more complications in many diseases. During treatment and repair, arteriosclerosis, abdominal congestion deposition, and abdominal swelling cannot be eliminated. In this paper, we used the seed growth method to obtain gold nanoparticles (AuNPs) with good morphology and dispersion. The AuNPs of larger aspect ratio synthesized in this experiment moved their longitudinal plasmon resonance absorption peak to the near-infrared region, which provided suitable materials for subsequent experiments and laid the foundation for the photothermal therapy of tumors. Experiments show that near-infrared rays can penetrate into deep tissues to overcome the shortcomings that visible light cannot penetrate abdominal aorta well. AuNPs absorb near-infrared rays, thereby generating heat energy to achieve the purpose of treating tumors. In addition, AuNPs also have fluorescent properties, combined with other forms of imaging methods, to achieve the purpose of multimodal imaging, and improve the diagnostic accuracy of studying the protection mechanism of the nephroblastoma overexpressed (NOV or CCN3) gene.
Achilles Tendon Xanthoma and Cholestanol Revealing Cerebrotendinous Xanthomatosis: A New Case Report
Authors: Ahmed Ghassem Mohamed , Mounach Aziza , H Djossou Julien , Toufik Hamza , El Ouardi Najlae , Achemlal Lahsen , Bezza Ahmed
Published: May 2021

Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disease rarely reported in Africa. Therefore, we report a Moroccan first case report of CTX. A 20-year-old woman was presented in our department for bilateral swelling of the posterior aspect of ankles and the anterior aspect knees with gait disturbances evolving since the age of 7. The patient was the first child of consanguineous marriage. She had bilateral cataracts and developmental delay. Laboratory findings revealed that the plasma cholestanol level was remarkably elevated, and plasma and urine bile alcohol levels were elevated. MRI of ankles showed a bilateral diffuse thickening of the Achilles tendon with hypointense in T1 and heterogeneous hypersignal in T2 with spots in hypersignal in T1 and T2. Brain MRI revealed bilateral and symmetrical T2 hypersignal of dentate nuclei, without white matter signal alterations or cerebral or cerebellar atrophy. A biopsy obtained of the Achilles swelling with a histological study showed an aspect of tendon xanthoma. Hence, the diagnosis of CTX was made. MRI, especially brain MRI, plays an important role in the diagnosis of CTX.
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells
Authors: Kwon Yoo-Wook , Ahn Hyo-Suk , Lee Jin-Woo , Yang Han-Mo , Cho Hyun-Jai , Kim Seok Joong , Lee Shin-Hyae , Yang Heung-Mo , Jang Hyun-Duk , Kim Sung Joo , Kim Hyo-Soo
Published: May 2021

Although human induced pluripotent stem cells (iPSCs) can serve as a universal cell source for regenerative medicine, the use of iPSCs in clinical applications is limited by prohibitive costs and prolonged generation time. Moreover, allogeneic iPSC transplantation requires preclusion of mismatches between the donor and recipient human leukocyte antigen (HLA). We, therefore, generated universally compatible immune nonresponsive human iPSCs by gene editing. Transcription activator-like effector nucleases (TALENs) were designed for selective elimination of HLA DR expression. The engineered nucleases completely disrupted the expression of HLA DR on human dermal fibroblast cells (HDF) that did not express HLA DR even after stimulation with IFN-γ. Teratomas formed by HLA DR knockout iPSCs did not express HLA DR, and dendritic cells differentiated from HLA DR knockout iPSCs reduced CD4+ T cell activation. These engineered iPSCs might provide a novel translational approach to treat multiple recipients from a limited number of cell donors.
Primary Echinococcus Hydatid Cyst of the Uterus: An Unusual Location
Authors: Ennaceur Farouk , Toumi Dhekra , Jaouad Farouk , Mabrouk Aymen , Hajji Ahmed , Gara Mouna , Chamakh Atef , Zouari Ines , Maatouk Mohamed , Daldoul Sami , Sayari Sofien , Haouet Karim , Safta Yacine Ben , Faleh Raja , Moussa Mounir Ben
Published: May 2021

Hydatidosis is a widespread anthropozoonosis. It can affect almost any part of the body, but it occurs most commonly in the liver (75%) and the lungs (15%). Its occurrence in female genital tract, especially the uterus, is very rare. Diagnosing hydatid disease at these unusual locations can be difficult. Hereby, we report two cases of primary hydatid cyst of the uterus. The first case is that of a 62-year-old woman, G7P5A2, who presented with an eight-month history of chronic pelvic pain. Clinical examination and radiological explorations revealed the presence of a uterine fibroid and a serous cystadenoma of the left ovary. She underwent a hysterectomy and a bilateral adnexectomy. Anatomopathological examination concluded that a serous cystadenoma of the left ovary was a calcified subserous hydatid cyst of the uterine fundus. The second case is that of a 69-year-old woman, G6P4A2, who consulted for chronic pelvic pain that had been evolving for 3 months. The clinical examination and radiological explorations doubted a hydatid cyst of the uterus, with a positive hydatid serology. She underwent a resection of the salient dome. The anatomopathological examination was in favor of a hydatid cyst of the uterus. Hydatid disease is endemic in Tunisia. The pelvic region is rarely affected with an incidence ranging from 0.3 to 0.9%, 80% of which involves the genitals. The uterus is more rarely affected than the ovaries. Most often, it is a contamination secondary to the intra-abdominal rupture of a hydatid cyst of the liver. However, primary uterine hydatid cysts have been reported. Surgery is the Gold Standard for the treatment of uterine hydatid cysts. Exploration of the abdominal cavity is essential in the search for other localizations, particularly hepatic. Postoperative medical treatment with Albendazole can be discussed. The ideal approach to deal with this public health concern is to emphasize the need for improved preventive measures. Modern imaging techniques have significantly improved the detection rates of hydatid cysts in atypical localizations. Indeed, the preoperative diagnosis of uterine hydatidosis requires a meticulous approach which is necessary to initiate an adequate treatment and thus guarantee a better management of the patient.
Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA
Authors: Xue Gen , Zhu Meijuan , Meng Ning , Guan Jianli , Zhang Jide , Yang Jing , Wang Yuefei , Cui Ying , Chai Xin
Published: May 2021

As a clinically effective traditional Chinese medicine injection (TCMI), Shuanghuanglian injection (SHLI) is widely used in the treatment of upper respiratory tract infection and pneumonia. However, the shortage of quality analysis is a limitation that remains to be improved in the clinical application of SHLI. In this study, taking advantage of ultra-high-performance liquid chromatography tandem Q-Exactive Orbitrap high-resolution mass spectrometry (UHPLC/Q-Orbitrap-MS), 31 chemical components (eight organic acids, eleven flavonoids, five iridoid glycosides, four phenylethanoid glycosides, and three lignans) in SHLI were characterized, among which 22 components were unambiguously identified by reference compounds. The brief prediction results of network pharmacology indicated that the 22 targeted components may have anti-inflammatory, antibacterial, antiviral, and immunomodulatory activities. Using multiwavelength switching method, the 22 targeted components were quantified by ultra-performance liquid chromatography with photodiode array detector (UPLC-PDA) after the methodological validation. Based on the successfully established method, the total content of 22 components in 20 batches of SHLIs was efficiently determined with a slight variation between 10.25 and 11.28 mg/mL, which accounted for 38.7% in total solid of SHLI. This study performed a reliable chemical identification and provided a rapid and effective method for quality analysis, which contributed to the in-depth investigation and application of SHLI.
Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma
Authors: Zhang Hai-Feng , Hughes Christopher S. , Li Wei , He Jian-Zhong , Surdez Didier , El-Naggar Amal M. , Cheng Hongwei , Prudova Anna , Delaidelli Alberto , Negri Gian Luca , Li Xiaojun , Ørum-Madsen Maj Sofie , Lizardo Michael M. , Oo Htoo Zarni , Colborne Shane , Shyp Taras , Scopim-Ribeiro Renata , Hammond Colin A. , Dhez Anne-Chloe , Langman Sofya , Lim Jonathan K.M. , Kung Sonia H.Y. , Li Amy , Steino Anne , Daugaard Mads , Parker Seth J. , Geltink Ramon I. Klein , Orentas Rimas J. , Xu Li-Yan , Morin Gregg B. , Delattre Olivier , Dimitrov Dimiter S. , Sorensen Poul H.
Published: May 2021

Cancer cells must overcome anoikis (detachment-induced death) to successfully metastasize. Using proteomic screens, we found that distinct oncoproteins upregulate IL1 receptor accessory protein (IL1RAP) to suppress anoikis. IL1RAP is directly induced by oncogenic fusions of Ewing sarcoma, a highly metastatic childhood sarcoma. IL1RAP inactivation triggers anoikis and impedes metastatic dissemination of Ewing sarcoma cells. Mechanistically, IL1RAP binds the cell-surface system Xc− transporter to enhance exogenous cystine uptake, thereby replenishing cysteine and the glutathione antioxidant. Under cystine depletion, IL1RAP induces cystathionine gamma lyase (CTH) to activate the transsulfuration pathway for de novo cysteine synthesis. Therefore, IL1RAP maintains cyst(e)ine and glutathione pools, which are vital for redox homeostasis and anoikis resistance. IL1RAP is minimally expressed in pediatric and adult normal tissues, and human anti-IL1RAP antibodies induce potent antibody-dependent cellular cytotoxicity of Ewing sarcoma cells. Therefore, we define IL1RAP as a new cell-surface target in Ewing sarcoma, which is potentially exploitable for immunotherapy.

Significance:

Here, we identify cell-surface protein IL1RAP as a key driver of metastasis in Ewing sarcoma, a highly aggressive childhood sarcoma. Minimal expression in pediatric and adult normal tissues nominates IL1RAP as a promising target for immunotherapy.

See related commentary by Yoon and DeNicola, p. 2679 .

This article is highlighted in the In This Issue feature, p. 2659
A Review of Applications of Machine Learning in Mammography and Future Challenges
Authors: Batchu Sai , Liu Fan , Amireh Ahmad , Waller Joseph , Umair Muhammad
Published: May 2021

Background: The aim of this study is to systematically review the literature to summarize the evidence surrounding the clinical utility of artificial intelligence (AI) in the field of mammography. Databases from PubMed, IEEE Xplore, and Scopus were searched for relevant literature. Studies evaluating AI models in the context of prediction and diagnosis of breast malignancies that also reported conventional performance metrics were deemed suitable for inclusion. From 90 unique citations, 21 studies were considered suitable for our examination. Data was not pooled due to heterogeneity in study evaluation methods. Summary: Three studies showed the applicability of AI in reducing workload. Six studies demonstrated that AI can aid in diagnosis, with up to 69% reduction in false positives and an increase in sensitivity ranging from 84 to 91%. Five studies show how AI models can independently mark and classify suspicious findings on conventional scans, with abilities comparable with radiologists. Seven studies examined AI predictive potential for breast cancer and risk score calculation. Key Messages: Despite limitations in the current evidence base and technical obstacles, this review suggests AI has marked potential for extensive use in mammography. Additional works, including large-scale prospective studies, are warranted to elucidate the clinical utility of AI.
Hypoxia-Inducible Factor 1 Alpha Is Dispensable for Host Defense of Group B Streptococcus Colonization and Infection
Authors: Lum Gregory R. , Mercado Vicki , van Ens Diede , Nizet Victor , Kimmey Jacqueline M. , Patras Kathryn A.
Published: May 2021

Group B Streptococcus (GBS) is a leading cause of neonatal morbidity and mortality, and the primary source of exposure is the maternal vagina. Intrapartum antibiotic prophylaxis for GBS-positive mothers has reduced the incidence of GBS early-onset disease, however, potential long-lasting influence of an antibiotic-altered neonatal microbiota, and the frequent clinical sequelae in survivors of invasive GBS infection, compels alternative treatment options for GBS. Here, we examined the role of transcription factor hypoxia-inducible factor 1 alpha (HIF-1α), widely recognized as a regulator of immune activation during infection, in the host response to GBS. Given the importance of endogenous HIF-1α for innate immune defense, and the potential utility of HIF-1α stabilization in promoting bacterial clearance, we hypothesized that HIF-1α could play an important role in coordinating host responses to GBS in colonization and systemic disease. Counter to our hypothesis, we found that GBS infection did not induce HIF-1α expression in vaginal epithelial cells or murine macrophages, nor did HIF-1α deficiency alter GBS colonization or pathogenesis in vivo. Furthermore, pharmacological enhancement of HIF-1α did not improve control of GBS in pathogenesis and colonization models, while displaying inhibitory effects in vaginal epithelial cytokines and immune cell killing in vitro. Taken together, we conclude that HIF-1α is not a prominent aspect of the host response to GBS colonization or invasive disease, and its pharmacological modulation is unlikely to provide significant benefit against this important neonatal pathogen.
Gallid Alphaherpesvirus 2 in the Egyptian Turkeys: Molecular Characterization and Establishment of a Universal System for Phylogenetic Classification
Authors: Bayoumi Mahmoud , El-Saied Mohamed , Ahmed Basem , El-Mahdy Magdy , Amer Haitham
Published: May 2021

Introduction: Gallid alphaherpesvirus 2 (GaHV-2) is a highly contagious oncogenic virus that causes Marek’s disease in chickens and occasionally in turkeys. Among 100 genes identified in GaHV-2 genome, the Meq gene appears to involve viral virulence, oncogenicity, and genetic diversity. Despite the use of Meq gene sequences in phylogenetic classification of GaHV-2 strains circulating in many countries worldwide, no integrated system exists yet. Methods: Turkeys from 2 commercial Egyptian farms were presented with signs of dullness, dehydration, and emaciation. Samples prepared from the internal organs were examined by histopathology and immunohistochemistry. Pools of the internal organs were analyzed by PCR for identification of GaHV-2, avian leucosis virus, and reticuloendotheliosis virus. The Meq gene of an Egyptian strain was sequenced and analyzed in comparison to 40 reference strains for generation of a universal system for phylogenetic classification of GaHV-2 strains. Results: Gross and histopathological examination revealed grayish-white soft masses in the internal organs characterized by diffuse infiltration of pleomorphic neoplastic cells. All lymphoma cells were identified as T-lymphocytes of CD3+ phenotype. Samples of both farms were only positive for GaHV-2 by PCR. Sequence analysis of the Meq gene has classified the current turkey strain as related to the Egyptian strains identified in chicken in 2012. A universal phylogenetic system for classification of GaHV-2 strains into 4 clusters was proposed. The vaccine strains were all grouped in cluster 2, and most of the classical American strains belonged to cluster 4. Cluster 1 was further divided into 3 subclusters (1.1–1.3). Conclusion: GaHV-2 was identified in turkeys for the first time in Africa and the Middle East. Sequence analysis of the Meq gene of the Egyptian strain along with a wide array of the global strains has enabled the construction of a novel phylogenetic classification system.
Role of Intermediate Care Unit Admission and Noninvasive Respiratory Support during the COVID-19 Pandemic: A Retrospective Cohort Study
Authors: Grosgurin Olivier , Leidi Antonio , Farhoumand Pauline Darbellay , Carballo Sebastian , Adler Dan , Reny Jean-Luc , Bollen Pinto Bernardo , Rossel Anne , Serratrice Jacques , Agoritsas Thomas , Stirnemann Jérôme , Marti Christophe
Published: May 2021

Background: The COVID-19 pandemic has led to shortage of intensive care unit (ICU) capacity. We developed a triage strategy including noninvasive respiratory support and admission to the intermediate care unit (IMCU). ICU admission was restricted to patients requiring invasive ventilation. Objectives: The aim of this study is to describe the characteristics and outcomes of patients admitted to the IMCU. Method: Retrospective cohort including consecutive patients admitted between March 28 and April 27, 2020. The primary outcome was the proportion of patients with severe hypoxemic respiratory failure avoiding ICU admission. Secondary outcomes included the rate of emergency intubation, 28-day mortality, and predictors of ICU admission. Results: One hundred fifty-seven patients with COVID-19-associated pneumonia were admitted to the IMCU. Among the 85 patients admitted for worsening respiratory failure, 52/85 (61%) avoided ICU admission. In multivariate analysis, PaO2/FiO2 (OR 0.98; 95% CI: 0.96–0.99) and BMI (OR 0.88; 95% CI: 0.78–0.98) were significantly associated with ICU admission. No death or emergency intubation occurred in the IMCU. Conclusions: IMCU admission including standardized triage criteria, self-proning, and noninvasive respiratory support prevents ICU admission for a large proportion of patients with COVID-19 hypoxemic respiratory failure. In the context of the COVID-19 pandemic, IMCUs may play an important role in preserving ICU capacity by avoiding ICU admission for patients with worsening respiratory failure and allowing early discharge of ICU patients.
Maternal Interleukin-6 Hampers Hippocampal Neurogenesis in Adult Rat Offspring in a Sex-Dependent Manner
Authors: Mouihate Abdeslam , Kalakh Samah
Published: May 2021

Maternal immune activation (MIA) during pregnancy leads to long-lasting effects on brain development and function. Several lines of evidence suggest that the maternal inflammatory cytokine interleukin (IL)-6 plays a crucial role in the long-lasting effects of MIA on adult offspring. IL-6 is naturally produced during pregnancy in the absence of any underlying immune activation. The objective of this study was to assess whether this naturally occurring IL-6 has long-lasting effects on brain plasticity and function. Therefore, pregnant rats were given either an IL-6-neutralizing antibody (IL-6Ab) or vehicle during the third week of pregnancy. Newly born (doublecortin) and mature neurons (NeuN) were monitored in the hippocampus of adult male and female offspring. Prenatal IL-6Ab led to an enhanced number of newly born and mature neurons in the dentate gyrus of the hippocampus of male but not female adult offspring. This enhanced neurogenesis was associated with an increased propensity in memory acquisition in male offspring. Blunting the naturally occurring IL-6 during pregnancy did not have a significant long-lasting impact on astrocyte cell density (GFAP), or on anxiety-like behavior as assessed with elevated plus maze and open field tests. Taken together, these data suggest that maternal IL-6 contributes, at least in part, to the programming of the brain’s development in a sex-dependent manner.
Efficacy of a Disease Management Program of a Tertiary Center and Ophthalmologic Practitioners for the Treatment of Neovascular Age-Related Macular Degeneration
Authors: Beka Sophie , Strauss Rupert Wolfgang , Podkowinski Dominika , Mursch-Edlmayr Anna Sophie , Mariacher Siegfried , Hofer Anna-Sophie , Bolz Matthias
Published: May 2021

Purpose: The aim of the study was to examine real-world data of patients with neovascular age-related macular degeneration (nAMD) within a disease management program (DMP) treated with anti-VEGF. Methods: A monocentric, retrospective chart review of 379 eyes of a local DMP was conducted at the Department of Ophthalmology, Kepler University Clinic Linz. Eyes were treated either with bevacizumab or aflibercept using a pro re nata scheme, consisting of 3 injections every 4 weeks in case of presence of disease activity. The observational period was up to 24 months. Disease activity was monitored by visual acuity (VA), clinical examination, and optical coherence tomography (OCT). For (re-)treatments, ophthalmologic practitioners referred patients directly to the intravitreal injection, avoiding redundant examinations. Results: VA improved significantly for all patients after 2 months (logMAR 0.47 ± 0.36; p = 0.000) compared to baseline (0.55 ± 0.37), and for the aflibercept group for up to 6 months (0.36 ± 0.27; p = 0.018). After 12 months, VA remained stable without further significant improvement and decreased by 24 months compared to baseline. The median number of injections was 6 over the first 12 months and 4 in the second year. Conclusion: Data revealed the efficacy of a DMP for nAMD involving both ophthalmologic practitioners and a tertiary center. Avoiding redundant examinations increased the efficacy of a clinical setting.
DSP improvement of a vector speed induction motor control with a RST and adaptive fuzzy controller
Authors: Youcef Mihoub , Djilali Toumi , Moreau Sandrine , Said Hassaine , Bachir Daoud
Published: May 2021

The aim of this work is to improve the dynamics and to overcome the limitation of conventional fixed parameters PI controller used in induction motor (IM) field-oriented control (FOC). This study presents and implements a RST and an adaptive fuzzy controller (AFC) to enhance variable speed control. Theoretical background of theses controllers is outlined and then experimental results are presented. Practical implementation has been realized on a board with a 1.1 KW IM supplied by 10 KHz space vector pulse width modulation current regulated inverter used as power amplifier consisted of 300V, 10A IGBT and Matlab/Simulink environment. Test benches have been established under different operating conditions in order to evaluate and compare the performances of the PI, IP, and polynomial RST and adaptive fuzzy controllers. Parameter variations for the rotor and the inertia moment variation were done in order to compare and verify the robustness of each controller. High dynamic performances and robustness against parameters variation were obtained with the use of both RST and AFC.
A remote patient monitoring based on WBAN implementation with internet of thing and cloud server
Authors: Majeed Jaber H. , Aish Qais
Published: May 2021

A healthcare employment is the mainly domain in emergent technology of WBAN, and an e-health system created of cloud computing in addition to a WSN considers an important part of this field. An implementation of remotely system for monitoring the patient's vital signs require continuous observation to form low-cost networks with the ability of portability and flexibility and may be applied with separate position and long-term intensive care of peoples in the absence of disturbance of their everyday activities. The patient carries body sensor's patches to get transmitted vital signs continuously to the cloud environment, and a website is designed for presenting and analyzing the data based on designed algorithm. A comparison is made every received measurement with a that stored in the algorithm. In remote specialist care, the execution of confidence and confidentiality conservation is critical, as essential restrictions were being communicating with remote locations. To ensure reliability, the implemented system offers real time monitoring and certification to the patient's condition by means of a medical record, with rapid medical data delivery to the medical staff and can also increase the service delivery ratio of hospital capacity and monitoring of large number of patients with concentrated average delay.
Optimal operation of thermal system based on optimum power flow
Authors: Hawas Majli Nema , Ibrahim Read K. , Sultan Ahmed Jasim
Published: May 2021

This paper has demonstrated that the Newton-Raphsin (NR) load flow technique can be stretched out to produce optimal load flow (OPF) arrangement that is achievable as for all significant disparity imperatives. These arrangements are frequently desired for arranging and activity. We were examined how the load ought to be shared among different plants, when line misfortunes are represented to limit the absolute activity cost with optimal power flow computation with thought about penalty factors, steady fuel cost, and coefficient factors. The IEEE three-machines and nine- Bus bars system was a tested system. The obtained results were compared by initial operation and equality distribution through the saving cost ($/year). The comparison of results showed saving more than 1.6 million $/year under MATLAB V.18a environment.
3D Reconstruction using convolution smooth method
Authors: Arifianto Sofyan , Wibowo Hardianto , Suharso Wildan , Novidianto Raditya , Harmanto Dani
Published: May 2021

3D imagery is an image with depth data. The use of depth information in 3D images still has many drawbacks, especially in the image results. Raw data on the 3D camera even does not look smooth, and there is too much noise. Noise in the 3D image is in the form of imprecise data, which results in a rough image. This research will use the convolution smooth methods to improve the 3D image. Will smooth noise in the 3D image, so the resulting image will be better. This smoothing system is called the blurring effect. This research has been tested on flat objects and objects with a circle contour. The test results on the flat surface obtained a distance of 1.3177, the test in the object with a flat surface obtained a distance of 0.4937, and the test in circle contour obtained a distance of 0.3986. This research found that the 3D image will be better after applying the convolution smooth method.
Embedded operating system and industrial applications: a review
Authors: Hee Yew Ho , Ishak Mohamad Khairi , Mohd Asaari Mohd Shahrimie , Abu Seman Mohamad Tarmizi
Published: May 2021

The complexity of an embedded system is directly proportional to the requirements of industrial applications. Various embedded operating system (OS) approaches had been built to fulfil the requirements. This review aims to systematically address the similarities and differences of the embedded OS solutions and analyse the factors that will influence decision-making when choosing what solution to use in the applications. This paper reviews three standard solutions; super loop, cooperative, and real-time operating system (RTOS). These are commonly used in industrial applications. By grouping the tasks in the foreground and background execution region, the concept and working principle of each of them are reviewed. The unique feature of RTOS in the context of task switching was used to define the deterministic characteristic of meeting the deadlines. The importance and performance of this characteristic is addressed and compared among various solutions in this paper. Subsequently, this paper reviewed the internet of things (IoT) requirements, automotive, medical and consumer electronics industry. The influential factors on choosing the right embedded OS to be used are extracted based on the requirements. They are reviewed in the perspective of memory footprint, regulated standards, cost-effectiveness, time effectiveness, and scalability.
A multiband patch antenna with embedded square split ring resonators in non-Homogeneous substrate
Authors: Rao Shailesh M. , Basarkod Prabhugoud I.
Published: May 2021

The authors have attempted to influence an embedded square split ring resonator (SSRR) response in a stacked non-homogeneous substrate to demonstrate a quad-band antenna. The purpose is to produce multiband operations of a microstrip patch antenna. The highlighted factor is the effect of embedding an SSRR and the differing relative permittivity of the substrate on the side length of the SSRR. The analysis shows that a non-homogeneous dual substrate patch produces multiple bands compared to a single substrate patch antenna without any parameter change. A dual substrate antenna fabricated using FR4 and Rogers RT/Duroid 5880 copper clad sheets with a dimension of 85.6x54x0.908 mm3 (0.314λ0x0.198λ0x0.003λ0). The antenna resonates at 1.1, 2.45, 3.65 and 5.25 GHz in the L-, S- and C-bands. It is possible to employ the patch antenna in WLAN (dual-band) and WiMAX applications and suitable for mobile broadcast service at 1.1 GHz. The authors compare the simulated and measured results of a prototype in the article. The maximum measured gain is 5.48 dBi at 1.1 GHz and 4.025 dBi at 3.65 GHz. The measured bandwidth is 60 MHz (1.2%) at 5.25 GHz.
Autonomous surface vessel for search and rescue operation
Authors: Mansor Hasmah , Norhisam Muhamad Haziq , Zainal Abidin Zulkifli , Gunawan Teddy Surya
Published: May 2021

Search and rescue operation is performed to save human life, for example during natural disasters, unfortunate incidents on the land, in the deepwater, or lakes. There were incidents happened to the search and rescue crew during the operation although they were well trained. A new method using robotic technology is important to reduce the crew's risk during operations. This research proposed a development of an autonomous surface vessel for search and rescue operations for deepwater applications. The proposed autonomous surface vessel is equipped with a global positioning system (GPS) and underwater sensor to search for the victims, black box, debris, or other evidence on the surface and underwater. The vessel was designed with monitoring and control via radio frequency wireless communication. The autonomous surface vessel prototype was developed and tested successfully with the telemetry at the ground station. The ground station acts as the control centre of the overall system. Results showed the vessel successfully operated autonomously. The operator at the ground station was able to monitor the sensor data and control the vessel's manoeuvre according to the created path. The telemetry coverage to monitor the water surroundings and control the vessel's manoeuvre was around 100 meters.
Method for automatic compensation of a single-phase earth fault
Authors: Zhankuanyshev Martebe K. , Kushkimbayeva Bibara Zh. , Egemberdieva Sofya Sh. , Esdauletova Zhanar S. , Yesmakhanova Laura N.
Published: May 2021

The paper demonstrates improving the reliability of power supply and operating safety of power receivers in electric networks of 6-10 kV, by controlling the neutral mode in extended electric networks of 6-10 kV with capacitive earth fault currents above 15 A. The purpose of the study is to increase the reliability of power supply and the safety of operation of power receivers in such electric networks, the establishment of patterns in controlling the neutral mode in extended 6-10 kV electric networks with capacitive earth fault currents above 15 A, as well as the development of a method and device automatic detection of single-phase earth fault current. Grounding methods and neutral modes in electric networks with a voltage of 6-10 kV are considered. The method and device for automatically determining the current of a single-phase earth fault were developed. In the result, the relationship between the active and inductive components of the neutral current during series RL grounding of the network Ia/IL=(0.5÷0.3) was established, which ensures reliable operation of the SPEF protection of both current and directional principles including the changes of capacity abruptly networks caused by switching outgoing lines.
Cyber-criminology defense in pervasive environment: A study of cybercrimes in Malaysia
Authors: Singh Manmeet Mahinderjit , Frank Richard , Wan Zainon Wan Mohd Nazmee
Published: May 2021

The growth of technologies; infrastructures and platforms with less or no security protection in emerging big data and internet of things (IoT) trends increase the likelihood of cybercrime attacks. With the rise of coronavirus disease-2019 (Covid-19) pandemic towards mankind, more cybercrimes are designed to penetrate one’s cognitive mind in revealing sensitive details. In this paper; an exploration of cybercrime threats in Southeast Asia country; Malaysia from year 2008 up to 2020 and its hike trends and impacts will be discussed. An investigation revolving the study of cyber-criminology and the reasoning behind the growth in terms of technological advancement will be presented. The findings suggest that the consequences and impacts of the cyberspace attacks are beyond the loss of money and reputations. It now becomes the failure of the global systemic altogether. As a mechanism to handle this would be to focus on protecting mission critical applications in pervasive environment. In this paper, a comprehensive authentication and authorization framework in safeguarding applications and users in the pervasive environment will be presented.
Morphological, structural and electrical properties of pentacene thin films grown via thermal evaporation technique
Authors: Ahmad Fatin Nor , Wijaya Yusmar Palapa , Mohamad Khairul Anuar , Nayan Nafarizal , Megat Hasnan Megat Muhammad Ikhsan , Alias Afishah , Ghosh Bablu Kumar
Published: May 2021

The physical and structural characteristics of pentacene thin films on indium tin oxide (ITO)-coated glass were studied. The pentacene films were deposited using the thermal evaporation method with deposition times of 20, 30, and 60 minutes. Field-emission scanning electron microscopy (FESEM) images revealed that film thickness increased with deposition time, with a bulk phase layer appearing at 60 minutes. The presence of the thin-film phase corresponding to 15.5 Å lattice spacing was demonstrated by X-ray diffraction (XRD) patterns in pentacene films with deposition times of 20 and 30 minutes. Meanwhile, with a deposition time of 60 minutes and a lattice spacing of 14.5 Å, the existence of the bulk phase was verified in the pentacene film. Atomic force microscopy (AFM) images of the crystallinity of the pentacene films revealed that the pentacene films deposited on ITO-coated glass exhibited the formation of similar islands with modular grains, results in a fine crystalline structure. From the current-voltage (I-V) and current density-voltage (J-V) characteristics, the pentacene films were ohmic and that current increased as the pentacene’s thickness decreased. Pentacene films deposited on an ITO-coated glass substrate showed potential in the development of broadband and narrowband optoelectronic devices on a transparent substrate.
SentiHotel: a sentiment analysis application of hotel services using an optimized neural network
Authors: Apriliani Dyah , Abidin Taufiq , Sutanta Edhy , Hamzah Amir , Somantri Oman
Published: May 2021

An assessed hotel service is necessary for tourists and everyone who is traveling, however currently it is still difficult to find recommended hotel information. The solution provided in this research is to propose a smart application that has been developed by implementing machine learning in it. The purpose is to build a sentiment review smart application by applying the sentiment analysis hybrid model of the best neural network (NN) algorithm model that has been optimized using genetic algorithms. To get the right model, the research method was carried out with experiments starting from the initial stages of conducting data preprocessing, tokenization, weighting, modeling experiments, and conducting the system evaluation stage to determine the success of the proposed model. The progress of the application development system is by using the prototyping model. SentiHotel is a sentiment application that was successfully built to provide a solution for tourists in assessing a hotel service. The software validation test is carried out using the blackbox method and the results show that the SentHotel application is in accordance with the expected result; all system functions can run properly.
Employing SiO2 nano-particles in conformal and in-cup structures of 8500 K white LEDs
Authors: Nguyen Thi My Hanh , Ton That Phung
Published: May 2021

SiO2 nano-particles have been examined in a distant phosphor structure for the elevated luminous quality and better consistency of white light-emitting diodes with angular-dependent associated color temperature (CCT). The luminous scattering ability could be increased by applying SiO2 nano-particles contain silicone to the outside of the phosphorus coating. In specific, the strength of blue light at wide angles is increased and differences in CCT can be minimized. In addition, owing to the sufficient refractive indices of silicone-containing SiO2 nanoparticles between the air and phosphorus layers, the luminous flux was improved. This new configuration decreases angular-dependent CCT deviations in the range of -700 to 700 from 1000 to 420 K. In comparison, at a 120 mA driving current, the rise of lumen flux increased by 2.25% relative to an usual distant phosphor structure without SiO2 nano-particles. As a result, in a distant phosphor structure, the SiO2 nano-particles could not only enhance the uniformity of illumination but also enhance the output of light.
A multistage successive approximation method for Riccati differential equations
Authors: Prabowo Petrus Setyo , Mungkasi Sudi
Published: May 2021

Riccati differential equations have played important roles in the theory and practice of control systems engineering. Our goal in this paper is to propose a new multistage successive approximation method for solving Riccati differential equations. The multistage successive approximation method is derived from an existing piecewise variational iteration method for solving Riccati differential equations. The multistage successive approximation method is simpler in terms of computing implementation in comparison with the existing piecewise variational iteration method. Computational tests show that the order of accuracy of the multistage successive approximation method can be made higher by simply taking more number of successive iterations in the multistage evolution. Furthermore, taking small size of each subinterval and taking large number of iterations in the multistage evolution lead that our proposed method produces small error and becomes high order accurate.
Hybrid approach redefinition-multi class with resampling and feature selection for multi-class imbalance with overlapping and noise
Authors: Ongko Erianto , Hartono Hartono
Published: May 2021

Class imbalance and overlapping on multi-class can reduce the performance and accuracy of the classification. Noise must also be considered because it can reduce the performance of classification. With a resampling algorithm and feature selection, this paper proposes a method for improving the performance of hybrid approach redefinition-multi class (HAR-MI). Resampling algorithm can overcome the problem of noise but cannot handle overlapping well. Feature selection is good at dealing with overlapping but can experience a decrease in quality if there is a noise. The HAR-MI approach is a way to deal with multi-class imbalance issues, but it has some drawbacks when dealing with overlapping. The contribution of this paper is to suggest a new approach for dealing with class imbalance, overlapping, and noise in multi-class. This is accomplished by employing minimizing overlapping selection (MOSS) as an ensemble learning algorithm and a preprocessing technique in HAR-MI, as well as employing multi-class combination cleaning and resampling (MC-CCR) as a resampling algorithm at the processing stage. When subjected to overlapping and classifier performance, it is discovered that the proposed method produces good results, as evidenced by higher augmented r-value, class average accuracy, class balance accuracy, multi class g-mean, and confusion entropy.
Enhancing the performance of cancer text classification model based on cancer hallmarks
Authors: Ali Noha , AbuEl-Atta Ahmed H. , Zayed Hala H.
Published: May 2021

Deep learning (DL) algorithms achieved state-of-the-art performance in computer vision, speech recognition, and natural language processing (NLP). In this paper, we enhance the convolutional neural network (CNN) algorithm to classify cancer articles according to cancer hallmarks. The model implements a recent word embedding technique in the embedding layer. This technique uses the concept of distributed phrase representation and multi-word phrases embedding. The proposed model enhances the performance of the existing model used for biomedical text classification. The result of the proposed model overcomes the previous model by achieving an F-score equal to 83.87% using an unsupervised technique that trained on PubMed abstracts called PMC vectors (PMCVec) embedding. Also, we made another experiment on the same dataset using the recurrent neural network (RNN) algorithm with two different word embeddings Google news and PMCVec which achieving F-score equal to 74.9% and 76.26%, respectively.
A comparison between deep learning, naïve bayes and random forest for the application of data mining on the admission of new students
Authors: Nurhachita Nurhachita , Negara Edi Surya
Published: May 2021

The process of admitting new students at Universitas Islam Negeri Raden Fatah each year produces a lot of new student data. So that there is an accumulation of student data continuously. The purpose of this study is to compare deep learning, naïve bayes, and random forest on the admission of new students as well as being one of the bases for making decisions to determine the promotion strategy of each study program. The data mining method used is knowledge discovery in database (KDD). The tools used are rapid miner. The attributes used are student ID number, name, program study, faculty, gender, place of birth, date of birth, year of entry, school origin, national examination, type of payment, and nominal payment. The new student data used from 2016 to 2019 was an 18.930 item. The results of this study used deep learning bayes results resulted in an accuracy value of 52.65%, naïve bayes results resulted in an accuracy value of 99.79%, and random forest results resulted in an accuracy value of 44.65%.
Implementation of generative adversarial networks in HPCC systems using GNN bundle
Authors: Karthik Ambu , Shetty Jyoti , G. Shobha , Dev Roger
Published: May 2021

HPCC systems, an open source cluster computing platform for big data analytics consists of generalized neural network bundle with a wide variety of features which can be used for various neural network applications. To enhance the functionality of the bundle, this paper proposes the design and development of generative adversarial networks (GANs) on HPCC systems platform using ECL, a declarative language on which HPCC systems works. GANs have been developed on the HPCC platform by defining the generator and discriminator models separately, and training them by batches in the same epoch. In order to make sure that they train as adversaries, a certain weights transfer methodology was implemented. MNIST dataset which has been used to test the proposed approach has provided satisfactory results. The results obtained were unique images very similar to the MNIST dataset, as it were expected.
Classification of skin cancer images by applying simple evolving connectionist system
Authors: Al-Khowarizmi Al-Khowarizmi , Suherman Suherman
Published: May 2021

Simple evolving connectionist system (SECoS) is one of data mining classification techniques that recognizing data based on the tested and the training data binding. Data recognition is achieved by aligning testing data to trained data pattern. SECoS uses a feedforward neural network but its hidden layer evolves so that each input layer does not perform epoch. SECoS distance has been modified with the normalized Euclidean distance formula to reduce error in training. This paper recognizes skin cancer by classifying benign malignant skin moles images using SECoS based on parameter combinations. The skin cancer classification has learning rate 1 of 0.3, learning rate 2 of 0.3, sensitivity threshold of 0.5, error threshold of 0.1 and MAPE is 0.5184845 with developing hidden node of 23. Skin cancer recognition by applying modified SECoS algorithm is proven more acceptable. Compared to other methods, SECoS is more robust to error variations.