bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural Compound Dioscin Targeting Multiple Cancer Pathways through
its High Affinity Binding to B Cell Lymphoma-2
Authors: Gulia Shweta , Chandra Prakash , Das Asmita
Published: February 2024

Objective::

The study aimed to explore the crucial genes involved in cancer-related
biological processes, including EMT, autophagy, apoptosis, anoikis, and metastasis. It also
sought to identify common genes among the pathways linked to these biological processes, determine
the level of Bcl-2 expression in various types of cancers, and find a potent inhibitor of
Bcl-2 among natural compounds.

Methods::

Common genes involved in the pathways related to EMT, autophagy, apoptosis,
anoikis, and metastasis were explored, and the level of the most frequently overexpressed gene
that was Bcl-2, in various types of cancers was analyzed by gene expression analysis. A set of
102 natural compounds was sorted according to their docking scores using molecular docking
and filtering. The top-ranked molecule was chosen for additional molecular dynamics (MD)
simulation for 100 ns. Differential gene expression analysis was performed for Dioscin using
GEO2R.

Results::

The study identified four common genes, Bcl-2, Bax, BIRC3, and CHUK, among the
pathways linked to EMT, autophagy, apoptosis, anoikis, and metastasis. Bcl-2 was highly overexpressed
in many cancers, including Acute Myeloid Leukemia, Diffuse large B cell lymphoma,
and Thymoma. The Dioscin structure in the Bcl-2 binding site received the highest docking
score and the most relevant interactions. Dioscin's determined binding free energy by
MM/GBSA was -52.21 kcal/mol, while the same calculated by MM/PBSA was -9.18 kcal/mol.
A p-value of less than 0.05 was used to determine the statistical significance of the analysis performed
using GEO2R. It was observed that Dioscin downregulates Bcl-2, BIRC3, and CHUK
and upregulates the pro-apoptotic protein Bax.

Conclusion::

The study concluded that Dioscin has the potential to act as a protein inhibitor,
with a noteworthy value of binding free energy and relevant interactions with the Bcl-2 binding
site. Dioscin might be a good alternative for targeting multiple cancer pathways through a single
target.
Thermal and Mechanical Investigation of Friction Stir Welding with
Disparate Materials AA6061 and AA7075
Authors: K Sabari , A Muniappan
Published: February 2024

Background::

The primary objective of this study is to assess the impact of welding
conditions on the mechanical properties of friction stir-welded butt joints created from two distinct
aluminium alloys, namely, AA6061 and AA7075. Friction stir welding (FSW), known for its innovation
and low-energy solid-state bonding technique, was employed in this research.

Methods::

FSW experiments were carried out on both AA6061 and AA7075 alloys using a computer
numerical control (CNC) machine. The selection and design of the tool geometry were meticulous,
with an emphasis on new pin profiles that are nearly flat at the weld contact point. Precisely,
four distinct tool geometries were machined from HC-HCr (High carbon, high chromium steel):
Circular, Square, Tapered third, and Triangular. Critical process variables that significantly influence
weld quality include rotation speed (800 rpm-1400 rpm) and traverse speed (12 to 25
mm/min). These variables were carefully optimized to achieve flawless welds. During the friction
stir welding process, the nugget zone undergoes significant deformation, leading to the formation
of a new microstructure that substantially impacts the mechanical properties of the joint.

Results::

This study comprehensively investigates the thermal and mechanical properties of friction
stir welding using aluminium alloys AA6061 and AA7075, considering various tool shapes.
Among the four tool shapes employed, two were found to yield higher hardness values (referred to
as BH). Notably, the square-shaped tool produced the highest temperature, reaching up to 690ºC,
as determined by thermocouple readings. Based on the findings, the optimal FSW parameters for
enhancing hardness involve an axial feed and spindle speed of 800 rpm combined with a feed rate
of 15 mm/min. These parameters were identified as crucial for achieving the desired mechanical
properties in the friction stir-welded joints.

Conclusion::

This study presents new developments in FSW technology, which may have patent
implications.
Corrigendum to: Investigation of the Apoptosis Inducing and β-catenin Silencing by
Tetradentate Schiff Base Zinc(II) Complex on the T-47D Breast Cancer Cells
Authors: Heidari Majd Mostafa , Guo Xiangyu
Published: February 2024

A typographical error appeared in the author affiliation titled “Investigation of the Apoptosis Inducing and β-catenin Silencing
by Tetradentate Schiff Base Zinc(II) Complex on the T-47D Breast Cancer Cells”, published in Anti-Cancer Agents in Medicinal
Chemistry, 2023, 23(15) [1].

Details of the error and a correction are provided here.

Original:

Author Affiliation: 2Department of Breast Medicine, Cancer Hospital Chinese Academy of Medical Science, Liaoning Provincial
Cancer Hospital, Shenyang, Liaoning, 110042, China

Corrected:

Author Affiliation: 2Department of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital,
Shenyang, China

We regret the error and apologize to readers.

The original article can be found online at https://www.eurekaselect.com/article/131718
Chemical Modifications Influence Genetic Information: The Role of Cytosine (De)Methylation in Plant Stress Responses
Authors: Costa Ferreira Neto José Ribamar , Vieira Viana Jéssica , Costa Borges Artemisa Nazaré , Daniel da Silva Manassés , Akio Kido Ederson , Pandolfi Valesca , Benko-Iseppon Ana Maria
Published: February 2024

Genetic information is fundamental in biology. It is stored in all genomes,
crucial to generating and maintaining a new organism. The biological importance of
DNA lies in its role as a carrier of genetic information and how it is expressed under
specific conditions. Among the different ways of controlling the manifestation of
genomic information (or gene expression), epigenetic mechanisms have been
highlighted. These mechanisms are diverse, multifunctional, and profoundly affect the
plant's molecular physiology. Cytosine methylation and demethylation - one of the
best-studied epigenetic mechanisms - is a dynamic process that influences,
respectively, the down- and up-regulation of target genes. The referred chemical
modifications occur in response to developmental processes and environmental
variations, and have their biological value accentuated as they can be passed on to
subsequent generations. This inheritance mechanism conducts ‘states of gene
expression’ to new cells and even to the offspring, allowing them to be ‘more adequate’
to the changing environment. The possibility of inheriting such chemical modifications
defies our understanding of the hereditary process, opening new perceptions and
practical implications. This chapter aims to address the cytosine methylation and
demethylation effects in plants. In the present review, we deal with how cytosine
(de)methylation occurs in plant genomes, their participation in the biotic and abiotic
stress responses, the recent studies for its use in crop breeding, and the epigenetic
inheritance issue, which is a matter of intense debate.
Sustainability of Agriculture and Global Food Supply Using Advanced Molecular Tools and Integrated Multi-omics and Gene Functions
Authors: Sharma Neerja , Kumar Pardeep , Ibrahim Mohd , Madaan Isha , Neha Bentham Science Publisher , Kaushik Shruti , Bhardwaj Savita , Kapoor Dhriti , Sirhindi Geetika , Pal Singh Amrit , Bhardwaj Renu
Published: February 2024

Food security has become the biggest challenge today due to the burgeoning
population and environmental impacts on crops. The agriculture system needs to meet
the food demand by using appropriate sustainable approaches while exerting minimum
impact on the ecosystem. Multiomics is one of the successful sustainable technologies
that contribute toward crop improvement and acceleration in food production.
Progressive development in next-generation sequencing for various omics like
genomics, transcriptomics, proteomics, metabolomics, ionomics and phenomics have
provided desired genetic resources for crop improvement. With the development of
molecular technology, new breeding tools are used for the transfer of genes from one
species to another. Biotic and abiotic stress-resistant traits are incorporated in
cultivating varieties to make them superior and produce a good yield. This chapter
solely summarizes the development of new traits with the help of new breeding tools
such as TALENs and CRISPR in plant breeding. The high throughput multi-omics
techniques are not only applicable for enhancing agricultural growth and yield but also
helpful in refining food security.
Ca+2 Channel Blockers
Authors: Rahman Taufiq , Faruk Khan M. O.
Published: February 2024

This chapter is a comprehensive account of the medicinal chemistry of
antihypertensive drugs, Ca2+-channel blockers (CCBs). It provides the mechanism of
drug action and detailed structure-activity relationships (SAR) of the CCBs to give the
knowledge base for pharmacists. After studying this chapter, students will be able to:

• Comprehend the historical background of the CCBs.

• Classify different types of voltage-gated Ca2+ channels (VGCCs) and their clinical
significance.

• Explain CCBs and their clinical significance.

• Describe the mechanisms of action of CCBs at the molecular level including their
binding modes against the VGCCs.

• Describe the SAR of the different classes of CCBs.

• Delineate clinical significance and therapeutic evaluations of these classes of drugs by
solving case studies.

• Articulate the discovery process of a few CCBs.
Diabetes and Antidiabetic Drugs
Authors: Faruk Khan M. O.
Published: February 2024

This chapter is a comprehensive account of diabetes and the medicinal
chemistry of antidiabetic drugs. It provides the mechanism of disease progression and
drug action and detailed structure-activity relationships (SAR) of antidiabetic drugs to
give the knowledge base for pharmacists. After studying this chapter, students will be
able to:

• Discuss the epidemiology and etiology of diabetes.

• Describe the clinical features of diabetes and differentiate between type I and type II
diabetes.

• Discuss various risk factors and corresponding mechanisms responsible for the
development of diabetes.

• Review biosynthesis of insulin, its metabolic outcomes, regulation of insulin
secretion, and insulin signaling.

• Explain in detail the pathophysiologic mechanisms responsible for the clinical
features of diabetes.

• Evaluate the clinical role of natural human insulin and commercially available other
insulin products and discuss its mechanism of action, pharmacokinetics, adverse
effects, motor complications, drug interactions, contraindications, and precautions.

• Discuss the mechanism of action, pharmacokinetics, adverse effects, motor
complications, drug interactions, contraindications, and precautions for each class of
antidiabetic drugs listed below.

o Sulfonylureas: tolbutamide (Orinase®
), tolazamide (Tolinase®
), chlorpropamide
(Diabinese®
), and acetohexamide (Dymelor®
), glyburide (Diabeta®
), glipizide
(Glucotrol®
), and glimepiride (Amaryl®
).

o Meglitinides: repaglinide (Prandin®
), nateglinide (Starlix®
).

o Biguanides: metformin (Glucophage®
, Glucophage XR).

o Peroxisome proliferator activated receptor (PPAR) agonists/Thiazolidinediones:
pioglitazone (Actos®
), rosiglitazone (Avandia®
).

o Alpha glucosidase inhibitors: acarbose (Precose®
).

o Glucagon-like peptide-1 (GLP-1) agonists: dulaglutide (Trulicity®
), exenatide
(Bydureon®
, Byetta®
), liraglutide (Victoza®
), lixisenatide (Adlyxin®
), semalgutide
(Ozempic®
, Rybelsus®
).

o Dipeptidyl peptidase-4 (DPP-4) inhibitors: alogliptin (Nesina®
), linagliptin
(Tradjenta®
), saxagliptin (Onglyza®
), sitagliptin (Januvia®
).

o Amylin agonist: pramlintide (Symlin®
).

o Sodium-glucose cotransporter-2 (SGLT2) inhibitors: empagliflozin (Jardiance®
),
canagliflozin (Invokana®
), dapagliflozin (Farxiga®
), ertugliflozin (Steglatro®
).

o Miscellaneous agents.
The use of gender-neuter marking in Brazilian Portuguese tweets: a sociolinguist approach
Authors: Baldez Diovana da Silveira , Brescancini Claudia Regina
Published: February 2024

This research investigates gender-neuter marking in Brazilian Portuguese, a recent lin guistic variation that has divided many opinions in Brazilian social and political circles until now. The Theory of Varia tion (LABOV, 2008 [1972]; WEINREICH; LABOV; HERZOG, 2006 [1968]), with a focus on Communities of Practice (ECKERT; MCCONNELL-GINET, 1992a, 1992b), supports the descriptio n and analysis conducted. To observe the variant, we opted for the social network Twitter, from which we collected 3,446 tweets produced by three subjects during the second half of 2020 who explic itly expressed a preference for the use of the neuter pronouns “Elu,” “Ilu,” “El” or “Ile.” As a selection criterion, we considered tweets containing adjectiv es, nouns, and pronouns whose referent was a human, and morphological markers carrying gender distinction. The predictor variables stipulated were morphosyntactic class, lexical ite m, the tweet topic, parti cipant, and the reference performed by gender marks (generic or specific). The sample was submitte d through the RStudio program, version 4.1.2, through which the proposed statisticaltreatment w as c arried o ut. T he r esults reveal a d isadvantage r egarding g ender-neuter marking for all partic ipants, not showing optimistic estimates about any specific word. They also pointed out the adjective class, the affective relationship and identity topics, and the generic reference performed by gender marking as conditioners of gender-neuter employment
Parataxis, hypotaxis, and subordination in Brazilian Sign Language: a brief introduction
Authors: Carneiro Bruno Gonçalves , El Khouri José Ishac Brandão , Santos Thamara Cristina , Ludwig Carlos Roberto
Published: February 2024

Clause articulation is a grammatical strategy found in all-natural languages. This phenomenon gives rise to complex constructions that manifest in a continuous gradient (parataxis – hypotaxis – embedding) from integratingsyntactic, semantic, and pragmatic levels of the language in use. The present study is guided by a functionalist perspective of language and aims to describe some articulation processes of sentences in Brazilian Sign Language (Libras). Regarding the Libras data, we noticed that juxtaposition, conjunctions, facial expressions, prolonged head nod, head nod linked to ALREADY mouthing, trunk displacement, and the maintenance of the non-dominant hand (buoy) could play a role. An essential role in the articulation of clauses or, at least, in the cohesion of the sentence.
Diferenças morfológicas entre o Português e o Chinês
Authors: Yuanying Deng
Published: February 2024

This work aims to analyze the morphological differences between Contemporary European Portuguese and Contemporary Mandarin Chinese, namely in the nominal inflection of gender and number, and verbal inflection of number, person, tense, mood, aspect and voice. By comparing examples of nominal and verbal inflection in Portuguese and their Chinese equivalent, it is our intention to clarify the necessary lexical resources in Chinese to express the changes in gender, number, person, tense, mood, aspect and voice. In addition, it will also be analyzed the affixation of auxiliary particles and lexical reduplication, which are considered forms of morphological alteration in Chinese
Sistem Monitoring Partikel (PM2.5) Air Purifier untuk Mengetahui Kualitas Udara Berbasis Sensor PMS5003 Dan Arduino
Authors: Suryantoro Hery , Kusriyanto Medilla
Published: February 2024

Udara dalam ruangan yang baik adalah udara yang berkualitas baik dan bebas polutan. Semakin baik kualitasnya, semakin sedikit udara tidak sehat yang dihirup. Sebaliknya, jika kualitas udara buruk, maka udara dapat memberikan dampak negatif terhadap organisme. PM 2.5 adalah partikel polutan udara yang berukuran sangat kecil sekitar 2.5 mikron, partikel ini berbentuk seperti debu, kotoran, jelaga, dan asap. Partikel PM 2.5 dapat menyebabkan berbagai gangguan pernafasan. Untuk mengetahui kualitas udara, pada penelitian ini dikembangkan air purifier yang dapat memantau partikel PM2.5 dan membersihkan udara. Prinsip kerjanya adalah udara sekitar diisap oleh kipas kemudian disaring melalui filter hepa, lalu udara bersih dikeluarkan kembali. Pada penelitian ini digunakan arduino uno, sensor PMS5003 sebagai pendeteksi kadar PM2.5, kipas sebagai pengisap udara, hepa filter sebagai filter udara. Metode penelitian yang digunakan adalah kajian pustaka, perancangan alat, pembuatan alat dan pengujian. Pengujian dilakukan dengan menempatkan air purifier di ruangan dengan tingkat polusi tinggi.  Air purifier berhasil menurunkan konsentrasi partikel PM2.5 pada ruangan berukuran 3 x 3 m dari 506 µg/m3 menjadi 50 µg/m3  dalam waktu 45 menit, dan nilai PM2.5 pada ruangan berukuran 5 x 7.5 m turun dari 669 µg/m3  menjadi 49 µg/m3  dalam  waktu 60 menit. Air purifier yang telah dirancang sangat efektif dalam mengurangi jumlah polutan PM2.5 sebesar 90 %, sehingga kualitas  udara menjadi  lebih baik.
Efektivitas Sistem Peminjaman Alat Online pada Masa Pandemi Covid-19
Authors: Nikmah Risalatun , Hamidah Hamidah , Sukamti Sri
Published: February 2024

Pandemi menyebabkan banyak terjadinya perubahan dan inovasi dalam bidang pendidikan karena keterbatasan ruang gerak. Salah satunya adalah keterbatasan pembelajaran tatap muka secara langsung dan praktikum di perguruan tinggi. Tujuan dari penelitian ini antara lain untuk menganalisis pengaruh sarana prasarana penunjang, pelatihan, komunikasi, pemahaman user serta user interface terhadap efektivitas sistem peminjaman alat online di Laboraotorium Jurusan Kebidanan Poltekkes Kemenkes Jakarta III. Penelitian ini merupakan penelitian survey, pengumpulan data menggunakan kuesioner, sampel berjumlah 60 responden. Data dianalisis dengan regresi berganda. Hasil penelitian menunjukkan terdapat pengaruh sarana dan prasarana penunjang (X1), penelitian (X2), komunikasi (X3), pemahaman user (X4) serta user interface (X5) secara parsial terhadap efektivitas sistem peminjaman alat online. Sedangkan pada pengamatan variabel komunikasi (X3) yang tidak mempengaruhi efektivitas sistem peminjaman alat online secara parsial. Secara simultan, variabel sarana dan prasarana penunjang (X1), pelatihan user (X2), komunikasi (X3), pemahaman user (X4) dan user interface (X5) mampu menjelaskan perubahan pada variabel efektivitas sistem peminjaman alat online. Saran untuk pengembangan sistem peminjaman alat ini yakni adanya pengembangan user interface dan fitur baru yang lebih memudahkan user dan dapat meminimalisisr kesalahan peminjaman.
Pengaruh Lembar Data Keselamatan Bahan Berbasis Kartu Referensi Cepat (Quick Reference Card) Terhadap Perilaku Aman (Safety Behaviour) Pengguna Laboratorium Pendidikan
Authors: Susanto Abiyyu Naufal , Satibi Lambang , Prasetyaningtyas Dwi Yuliastuti
Published: February 2024

Mengelola keamanan penggunaan bahan laboratorium di perguruan tinggi menjadi sangat penting mengingat banyaknya kecelakaan di laboratorium pendidikan yang telah dilaporkan di seluruh dunia melibatkan para pengguna laboratorium pendidikan. Lembar Data Keselamatan Bahan (LDKB) perlu disajikan dalam satu bentuk yang lebih mudah dipahami pengguna laboratorium pendidikan dalam waktu yang singkat. Studi ini terutama ditujukan untuk mengkaji bagaimana Lembar Data Keselamatan Bahan (LDKB) berbasis Quick Reference Card (QRC) secara langsung dapat mempengaruhi perilaku aman (safety behaviour) di laboratorium pendidikan bagi kalangan mahasiswa keperawatan. Penelitian ini menerapkan pre-experimental one-group pre test post test design dengan hanya melibatkan satu kelompok yang diintervensi. Studi ini didasarkan pada total sampling dari 144 mahasiswa tingkat akhir yang berasal dari dua program studi di Keperawatan Poltekkes Kemenkes Semarang Kampus V Magelang. Penelitian dilaksanakan di Laboratorium Keperawatan Magelang Poltekkes Kemenkes Semarang pada bulan Mei 2023. Data dianalisis dengan menggunakan uji statistik nonparametrik wilcoxon karena data tidak terdistribusi normal. Metode LDKB berbasis QRC terbukti memiliki efektivitas tinggi dalam meningkatkan perilaku keselamatan (safety behaviour) responden karena nilai rata-rata (mean) dari N Gain Score lebih besar sama dengan 0,7 yaitu sebesar 0,7944. Temuan uji wilcoxon menunjukkan bahwa nilai signifikansi sebesar 0,000 atau <0.05 sehingga terdapat pengaruh LDKB berbasis QRC terhadap perilaku keselamatan (safety behaviour) mahasiswa di laboratorium pendidikan keperawatan.
Analisis Cek List Keselamatan dan Kesehatan Kerja di Laboratorium Biologi Laut
Authors: Helvitri Helvitri , Firda Firda
Published: February 2024

Tingginya potensi kecelakaan di laboratorium, maka keselamatan dan kesehatan kerja di laboratorium perlu diperhatikan. Bahan kimia, peralatan, fasilitas tambahan, dan personel adalah beberapa dari banyak komponen yang ditemukan di laboratorium yang digunakan untuk mengevaluasi risiko kecelakaan. Mengingat tingginya kemungkinan terjadinya kecelakaan, teknik peninjauan dan penilaian harus digunakan dalam pelaksanaan keselamatan dan kesehatan kerja. Penelitian ini menggunakan checklist keselamatan dan kesehatan kerja untuk mengkaji kesehatan dan keselamatan kerja di laboratorium Biologi Laut. Data di sajikan dalam bentuk tabel dan grafik, statistik deskriptif digunakan untuk analisis. Hasil analisis informasi berdasarkan nilai normatif adalah x ≥ 262, 5 (jenis sangat baik), 175≤ s/d 262, 5 (jenis baik), 88≤ s/d 175 (jenis lumayan baik) serta x≤ 88 (jenis tidak baik). Dengan skor rata-rata sebesar 245,33, didapat hasil pemeriksaan check list keselamatan dan kesehatan kerja laboratorium Biologi Laut secara keseluruhan masuk dalam kategori baik. Matriks acuan daftar periksa keselamatan dan kesehatan kerja di laboratorium, yang mencakup tata letak kantor, laboratorium, APD, perlengkapan kebersihan, peralatan darurat, bahan kimia, peralatan gelas, dan sistem kelistrikan, semuanya membuktikan hal ini.
Pengaruh Penggunaan Video Tutorial Merangkai Alat Praktikum Terhadap Pemahaman dan Pengetahuan Mahasiswa pada Praktikum Isolasi dan Sintesis Senyawa Organik
Authors: Surani Surani
Published: February 2024

Laboratorium kimia organik dan biokimia (LKOB) merupakan bagian dari laboratorium yang ada di Departemen Pendidikan Kimia Fakultas Pendidikan Matematika dan Ilmu Pengetahuan Alam Universitas Pendidikan Indonesia. Salah satu praktikum yang ada di LKOB adalah praktikum Isolasi dan Sintesis Senyawa Organik. Tujuan dari penelitian ini untuk mengetahui pengaruh diberikannya video tutorial merangkai alat terhadap pemahaman dan pengetahuan mahasiswa . Subyek pada penelitian ini adalah mahasiswa prodi pendidikan kimia sebanyak 39 orang(kelas kontrol) dan prodi kimia 32 orang(kelas eksperimen). Pada penelitain ini instrumen yang digunakan berupa pertanyaan yang harus dijawab oleh mahasiswa dalam bentuk pre-test sebanyak 3 soal dan pos-test 3 soal. Dari data yang dihasilkan untuk kelas kontrol rata – rata nilai pre-test 59,07 dan nilai pos-test 59,62, sedangkan untuk kelas eksperimen rata-rata nilai pretes 62,97 dan nilai postes 72,5 . Berdasarkan hasil uji t  tes dihasilkan data untuk kelas kontrol  nilai –p = 0,954 > 0,025 artinya tidak ada perbedaan antara rata-rata pre-tes dan post-test. Untuk kelas eksperimen niali –p = 0,104 > 0,025 aritnya tidak ada perbedaan yang berarti antara rata-rata pre-test dan post-test , meskipun untuk kelas eksperimen terdapat kenaikan nilai rata-rata dari pre-test 62,97 dan nilai post-test 72,5 (terdapat selisih sebesar 9.53) akan tetapi perbedaannya belum berpengaruh secara berarti terhadap pemahaman dan pengetahuan mahasiswa.
Pembuatan Preparat Awetan Embrio Utuh Burung Puyuh (Cortunix - Cortunix Japonica)
Authors: Aprira Aprira , Edward Edward , Lestari Dian Fita
Published: February 2024

Salah satu materi praktikum Embriologi Pekembangan Hewan adalah kegiatan pengamatan pekembangan embrio hewan kelas Aves. Pada praktikum ini mahasiswa menggunakan salah satu bahan yang berupa preparat awetan yang tersedia di laboratorium. Kegiatan praktikum meliputi pengamatan dari perkembanagn embrio ayam usia 18,24,36, 48,60, 72 dan 96 jam. Sediaan preparat awetan dari spesies aves yang berbeda diperlukan sebagai perbandingan perkembangan embrio. Salah satu spesies aves yang cukup mudah didapatkan sediaan telur dengan waktu perkembangan embrio yang cukup berbeda dibandingkan dengan ayam adalah burung dari jenis cortunix-cortunix japonica atau burung puyuh. Sedian preparat awetan embrio utuh ini sangat penting untuk meningkatkan kelancaran dan peningkatan pengetahuan mahasiswa. Penelitian dilakukan dengan tujuan untuk membuat preparat awetan utuh embrio burung puyuh pada masa inkubasi 24,36,48,60,72,84 dan 96 jam. Sampel yang digunakan adalah telur puyuh fertil  yang diinkubasi pada suhu 380C. Embrio akan dipisahkan dari kuning telur, lalu embrio dibersihkan, di warnai dan dijernihkan dengan menggunakan alkohol bertingkat dan xylol sehingga perkembangan dari masing masing embrio terlihat jelas. Dapat disimpulkan yaitu telur burung puyuh fertil yang diinkubasi dengan masa inkubasi 24,36,48,60,72,84, dan 96 jam, embrionya dapat dipisahkan dan dapat dibuat preparat utuh serta dapat diamati di mikroskop Preparat dari embrio burung puyuh perkembangannya hampir mirip dengan embrio ayam tetapi pada umur inkubasi yang sama embrio burung puyuh telah mengalami tehapan perkembangan yang lebih lanjut dari pada embrio ayam.
The Formation Causes and Governance Strategies of Digital Formalism in Township Government from the Perspective of Policy Implementation Process
Authors: Wang Minghu
Published: February 2024

In the era of big data, higher-level governments usually use digital technology to monitor and quantify the policy implementation of grass-roots governments in real time through digital indicators. In the case of fulfilling the tasks and objectives of the higher government on time, in quantity and unconditionally, the grass-roots government is usually burdened with a huge digital burden, exposing the formalistic behaviors such as digital coping behaviors and digital tournaments. Taking the “Rectification of land map spots” policy as an example, this paper describes the digital formalism of township government from two aspects of digital coping behavior and digital tournament and explores the reasons behind the digital formalism of township government from the aspects of pressure from multiple sources, constraints from internal and external environment, and lack of digital literacy of policy subjects. Then, it puts forward some strategies and methods to solve the digital formalism of township government from the aspects of optimizing the structure and mechanism construction of township government policy implementation, improving the environmental support of township government policy implementation, and improving the digital literacy of policy subjects.
Recertificación ISO 9001 en un área de proyectos de tecnología de información
Authors: Ventura Miranda María Teresa
Published: February 2024

El estándar ISO 9001 es el principal referente para la implementación de prácticas de gestión de calidad en todo tipo de organizaciones. Los sistemas de gestión de calidad pueden ser implementados en áreas de tecnologías de información para formalizar sus procesos internos y mejorar la calidad de los productos y servicios que ofrecen a sus clientes y usuarios. Tal es el caso de un área dedicada al desarrollo de proyectos de tecnología de la información dentro de una universidad pública mexicana, que se ha certificado desde hace varios años y ha sintetizado un conjunto de actividades clave que permiten mantener en mejora continua su sistema de gestión de calidad enfocado al desarrollo de proyectos, así como renovar satisfactoriamente su certificación ISO 9001:2015. Estas actividades clave comprenden: la planeación anual, el análisis de la organización, la revisión del sistema y su documentación, la realización de auditorías (interna y externa) y la evaluación de resultados por parte de los directivos de la organización.
Análisis del sector agropecuario en los procesos de la liberalización económica de México (1980-2019)
Authors: Honofre Bastian Dulce Karime
Published: February 2024

El presente trabajo tiene por objetivo exponer y concientizar sobre la situación que enfrenta el sector agropecuario, y cómo sería más eficiente y eficaz si el gobierno mexicano hubiese extendido en momentos críticos ayuda a los trabajadores del área, posterior a la crisis de 1982; así mismo esclarece la importancia de los tratados comerciales de México como herramienta principal hacia la liberación económica, la trascendencia de estos sobre el PIB mexicano, el contexto de los trabajadores y el de sus hogares.
La responsabilidad social de la Administración Pública en México. Pequeña reflexión sobre el Plan Nacional de Desarrollo
Authors: Gómez Bouret José Adolfo
Published: February 2024

En este texto se menciona la importancia de la teoría de la administración pública para el cumplimiento del compromiso social que se tiene por alcanzar el bienestar social. Asimismo, se aborda la importancia de la gestión pública para reflexionar su enfoque social en la planeación y solución de problemas públicos mediante políticas públicas. Considerando al Plan Nacional de Desarrollo como una declaratoria de compromiso social para alcanzar el bien común, teniendo un marco de derechos sociales como ruta de planeación estratégica. Concluyendo con una crítica general sobre aspectos del actual PND para exhibir si es o no una verdadera declaratoria de compromiso social.
Breast Cancer Detection Using Artificial Intelligence
Authors: Johar Mr. Amratsingh
Published: February 2024

Abstract: Breast cancer is one of the most common diseases faced by women and causes more deaths every day. It is considered one of the greatest diseases in medical history. Automated diagnostic systems not only assist diagnosticians but also provide reliable, efficient and fast services that reduce the likelihood of death. This paper proposes a model to manually classify breast cancer samples into benign and malignant subcategories using multiple algorithms to predict interpretation. It is generally considered as all data containing a set of 30 characteristics related to the nuclei found in digitized images of fine needle aspiration (FNA) of the breast. All acquired features are visualized and understood to gain insight for future diagnoses. Breast cancer prediction uses support vector distribution (SVC) in its ability to identify new, unrecognized data based on a set of features.
Artificial Neural Networks for Long-Bone Fracture Detection Based on X-Ray Image Contour Features
Authors: Harkude Ganesh Aravind
Published: February 2024

Abstract: Two contour-based fracture detection strategies are presented in the ensuing research. The programs are designed to help medical practitioners identify human long bone fractures from X-ray pictures. The line-based fracture detection systems suggested in [1] served as the foundation for the creation of the contour-based fracture. Convolutional Neural Networks (CNN) are widely used in current Computer Aided Diagnosis (CAD) systems to classify broken X-ray images. Even while the current CAD systems achieve excellent accuracy, doing so comes at a cost: a large volume of training data. By using identified contours in X-ray pictures, the suggested techniques aim to achieve high classification accuracy with little training data. Two methods exist for contour-based fracture detection. The first is the enhanced CHFB scheme, while the second is the Standard Contour Histogram Feature-Based (CHFB). The modified CHFB scheme differs from the other one in that it removes the detected flesh contours surrounding the leg region.
A hybrid quantum algorithm to detect conical intersections
Authors: Koridon Emiel , Fraxanet Joana , Dauphin Alexandre , Visscher Lucas , O'Brien Thomas E. , Polla Stefano
Published: February 2024

Conical intersections are topologically protected crossings between the potential energy surfaces of a molecular Hamiltonian, known to play an important role in chemical processes such as photoisomerization and non-radiative relaxation. They are characterized by a non-zero Berry phase, which is a topological invariant defined on a closed path in atomic coordinate space, taking the value π when the path encircles the intersection manifold. In this work, we show that for real molecular Hamiltonians, the Berry phase can be obtained by tracing a local optimum of a variational ansatz along the chosen path and estimating the overlap between the initial and final state with a control-free Hadamard test. Moreover, by discretizing the path into N points, we can use N single Newton-Raphson steps to update our state non-variationally. Finally, since the Berry phase can only take two discrete values (0 or π), our procedure succeeds even for a cumulative error bounded by a constant; this allows us to bound the total sampling cost and to readily verify the success of the procedure. We demonstrate numerically the application of our algorithm on small toy models of the formaldimine molecule (H2C=NH).
Analysis of Students' Error in Working on Story Problems Based on Newman's Criteria in Class II MIA 3 Man 3 Padang
Authors: Surya Fajar , Edriati Sofia
Published: February 2024

The background of this research is that there are still many students who are less interested and motivated in learning mathematics so that many students make mistakes in solving math word problems. The purpose of this research is to identify and identify the types of mistakes made students in working on word problems based on Newman's Error criteria and knowing the causes of students making mistakesIn doing story problems.The research method used is descriptive method with a qualitative approach . The sample of this study were 24 students of class XI MIA 3. The research instrument was tests and interviews. The test results were analyzed based on Newman's criteria, after which students were interviewed based on the types of mistakes made by students.The results of this study indicate that the types of errors made by students based on Newman's criterion analysis consist of 5 errors, namely Reading errors, Comprehension errors, Transformation errors, Process Skill errors and Endcoding errors. The biggest mistake was made at the stage of writing the final answer, namely as much as 46.67%, while the smallest error was made at the stage of understanding the questions, namely as much as 5.33%.
MANUFATURA ADITIVA NA FUNDIÇÃO DE CHUMBO: UM ESTUDO DE CASO NA FABRICAÇÃO DE UM MOLDE DE SILICONE
Authors: Valentini Hernani , Aita Carlos Alfredo Gracioli , Toso Marcelo André
Published: February 2024

A manufatura aditiva ou impressão 3D produzem peças a partir da adição de material, geralmente camada sobre camada. Este processo difere-se de métodos tradicionais de fabricação, que consistem na retirada sucessiva de material. O presente artigo propõe a elaboração de um molde de fundição permanente, de baixo custo, para realizar a fabricação de contrapesos de chumbo do tipo garra baixa. Para isso, foram fabricados dois modelos por meio da manufatura aditiva, um modelo produzido pelo método de modelagem por deposição fundida e o outro pelo método de processamento digital por luz. Posteriormente, a partir destes modelos, foram construídos dois moldes com a utilização de borracha de silicone, que suporta temperaturas de até 360 ºC. Após a construção dos moldes, foram realizados testes de fundição de chumbo para analisar o comportamento destes. Utilizando um sistema de aquisição de dados e um termopar, constatou-se que a maior temperatura que o molde é submetido durante a fundição do contrapeso de chumbo, é, em média, 167 ºC. Conclui-se que o molde de silicone produzido (classificado como permanente) apresenta resistência adequada durante a fundição de chumbo, tornando-se uma alternativa de baixo custo, frente aos processos convencionais de fabricação frequentemente utilizados.
The Impact of Covid-19 on The Execution of Audits in Malaysia
Authors: Kamaruddin Muhammad Iqmal Hisham , Mohd Hanefah Mustafa
Published: February 2024

Research aim: This study aims to investigate the impact of the Covid-19 pandemic on the execution of audits in Malaysia. This study also will examine the readiness of Malaysian auditors to work from home (WFH). Design/ Methodology/ Approach: A questionnaire survey was employed with 171 Malaysian external auditors participating. Research finding: This study found that all three audit areas – audit planning and fieldwork, group audit engagement and auditors' reports – were highly impacted due to Covid-19. As for readiness to WFH, results show that Malaysian auditors are not ready to implement the approach. Conversely, Malaysian audit firms were ready to implement WFH. Theoretical contribution/ Originality: This study is among the few identifying the impact of Covid-19 on the execution of audits. It also contributes by identifying auditors’ and audit firms’ readiness to implement a WFH approach. Practitioner/ Policy implication: This study will benefit audit firms especially in implementing a WFH approach.
The Dynamics of Individual Investment Decisions: Evidence From The Dhaka and Chittagong Stock Exchange, Bangladesh
Authors: Sagar Awlad Hosen , Rahman Sharon Mustafizur
Published: February 2024

Research aim: Behavioural finance plays an analogous role to fundamental and technical analyses for investment decisions in the stock market. It deals with various factors that manipulate investment decisions. This study explores the factors influencing individual investment decisions in the Dhaka and Chittagong Stock Exchange (DSE and CSE) of Bangladesh. Design/Methodology/Approach: Based on existing finance theories and literature, several factors were included in the self-developed questionnaire, with data collected using random sampling. We used SPSS (Version 26) to analyse the primary data collected. In the questionnaire, there were 24 variables, and statistical analysis (multiple regression) was carried out. Research finding: There were 24 variables, five of which (i.e., investor experience, impact of P/E ratio, impact of fundamental analysis, impact of securities and brokerage firm, and impact of investor psychology) had significant impact on individual investment decisions in the CSE and DSE. Theoretical contribution/ Originality: Theories pertaining to individual investment decisions are based on individual judgment, sentiment, risk perception, and risk attitude. These mechanisms are associated with behavioural finance. Various behavioural finance studies have been conducted in developed countries, but not in developing countries like Bangladesh. As such, the dynamics of the investment decision are the main focus of the present study. Practitioner/ Policy implication: This article can serve as input to investment decisions that have an impact on economic value at the firm, industry, and macroeconomic level. Moreover, it highlights the role of related stakeholders and extent to which they influence investment decisions. Research limitation: This study is country-specific, and the number of respondents is limited to 125 only. We could not consider the impact of technological advancement during this period.
A Full-Depth Sea Level Rise Budget in the Southwest Pacific Basin using Deep Argo
Authors: Lele Ratnaksha , Purkey Sarah G.
Published: February 2024

Using nine years of full-depth profiles from 55 Deep Argo floats in the
Southwest Pacific Basin collected between 2014 and 2023, we find
consistent warm anomalies compared to a long-term climatology below 2000
m ranging between 11±2 to
34±2moC, most pronounced between 3500
and 5000 m. Over this period, a cooling trend is found between 2000-4000
m and a significant warming trend below 4000 m with a maximum rate of
4.1±0.31 moC yr-1 near
5000 m, with a possible acceleration over the second half of the period.
The integrated Steric Sea Level expansion below 2000 m was
7.9± 1 mm compared to the climatology with a trend of
1.3± 1.6 mm dec-1 over the Deep Argo
era, contributing significantly to the local sea level budget. We assess
the ability to close a full Sea Level Budget, further demonstrating the
value of a full-depth Argo array.
Wyniki ekonomiczne gospodarstw indywidualnych województwa białostockiego, prowadzących różne kierunki produkcji na glebach lekkich
Authors: Snarski Sławomir
Published: February 2024

Badania gospodarstw województwa białostockiego, prowadzących produkcję rolniczą na glebach lekkich wykazały, że gospodarstwa te osiągają dość dobre stabilne wyniki ekonomiczne. Wykazały również zróżnicowanie wyników ekonomicznych w poszczególnych kierunkach produkcji. Najwyższy dochód rolniczy brutto, na przestrzeni pięcioletniego okresu badawczego lat 1989-1993, osiągnęły gospodarstwa o trzodowym kierunku produkcji. Również te gospodarstwa osiągnęły najwyższą produktywność i dochodowość ziemi oraz produktywność i dochodowość pracy. Bardzo niepokojącym zjawiskiem był relatywnie niski dochód rolniczy z gospodarstwa, przypadający na jednostkę pełnozatrudnionej siły roboczej w gospodarstwie, w stosunku do wynagrodzenia, jakie otrzymywał statystyczny pracownik zatrudniony w innych działach gospodarki narodowej. W tym zestawieniu dochód rolniczy praktycznie w każdym kierunku produkcji był niższy w porównaniu do średniego wynagrodzenia uzyskiwanego z pracy poza rolnictwem. To stawia gospodarstwa w trudnej sytuacji na przyszłość, gdyż dochód rolniczy, oprócz zabezpieczenia konsumpcji rodziny rolniczej na przyzwoity
“Com-versas de bar” sobre turismo e educação
Authors: Silva Renan de Lima da , Baptista Maria Luiza Cardinale
Published: February 2024

O texto traz o relato de experiência e reflexões, do projeto “Com-versas de Bar”, atividade extensionista vinculado ao Laboratório de Turismo e eventos da UNIRIO. O projeto buscou propor espaços horizontais de ‘com-versas’ sobre Turismo e Educação. Em termos teóricos, o alinhamento é ecossistêmico complexo, associado à Educação e ao Turismo, bem como à Esquizoanálise e à Biologia Amorosa, do Conhecimento e Cultural para a abordagem da subjetividade. O texto tem orientação na estratégia metodológica complexa e processual de Baptista, denominada “Cartografia dos Saberes”, em associação com as provocações de Rubem Alves, em texto clássico sobre a Educação. O projeto teve reverberações no grupo de sujeitos envolvidos, com significados de experiência de ensino-aprendizagem transversal, pautado pela horizontalidade de relações em trama de afetos e vivências. Entende-se que a Educação tem forte laço com o Turismo, por seus traços característicos relativos à viagem e à busca do encontro.
Ensino superior privado no Brasil
Authors: Bueno Elenice , Martins Manfio João Nicodemos , Martins Rodrigo
Published: February 2024

Esse trabalho visa analisar o contexto do ensino superior privado no Brasil, traçando paralelos sob as perspectivas do antropólogo Roberto DaMatta (1997), o sociólogo francês Pierre Bourdieu (1975) e o sociólogo polonês Zygmunt Bauman (2013). O objetivo é evidenciar algumas características da cultura brasileira de modo a compreender disputas de poder e desigualdades no modelo reprodutor do ensino em tempos líquidos. A partir da leitura e análise desses autores, embora se encontrem em contextos e épocas diferentes, será possível apontar que a educação superior privada acaba por reproduzir desigualdades ao invés de promover justiça social e transformações efetivas. Razão pela qual nos parece inevitável e urgente a criação de alternativas interdisciplinares e diálogos provindos de análises socioculturais que somem aos debates da área da educação.
Wiring the Brain for Wellness: Sensory Integration in Feeding and Thermogenesis: A Report on Research Supported by Pathway to Stop Diabetes
Authors: Riera Céline E.
Published: February 2024

The recognition of sensory signals from within the body (interoceptive) and from the external environment (exteroceptive), along with the integration of these cues by the central nervous system, plays a crucial role in maintaining metabolic balance. This orchestration is vital for regulating processes related to both food intake and energy expenditure. Animal model studies indicate that manipulating specific populations of neurons in the central nervous system which influence these processes can effectively modify energy balance. This body of work presents an opportunity for the development of innovative weight loss therapies for the treatment of obesity and type 2 diabetes. In this overview, we delve into the sensory cues and the neuronal populations responsible for their integration, exploring their potential in the development of weight loss treatments for obesity and type 2 diabetes. This article is the first in a series of Perspectives that report on research funded by the American Diabetes Association Pathway to Stop Diabetes program.

Article Highlights
The Muculent Bleb-Mucinous Cystic Neoplasm-Hepatobiliary Region
Authors: Bajaj Anubha
Published: February 2024

Mucinous cystic neoplasm configures as a cystic neoplasm incriminating the hepatic parenchyma. Tumour is constituted of multi-locular or cystic cavity layered with mucinous or biliary type epithelium encompassed within an ovarian type stroma. The cystic lesion appears non communicative with adjoining bile ducts. Additionally designated as hepatobiliary cystadenoma, biliary cystadenoma or cystadenoma with mesenchymal stroma, neoplasms associated with invasive carcinoma component may be denominated as hepatobiliary cystadenocarcinoma.
A Rare Case of Endometriosis in Urinary Bladder
Authors: Kundu Shilpi
Published: February 2024

Endometriosis with involvement of urinary tract is a rare occurrence. It is a chronic condition with presence of endometrial tissue outside uterine cavity. Most likely location is peritoneal surface of pelvis. We present a case of 32 year old female presenting with pelvic pain. On sonography bladder mass was detected. Transurethral resection of bladder mass revealed foci of endometriosis with mild inflammation in stroma. The diagnosis relies on identification of atleast two of the three components: endometrial glands, endometrial stromal cells or recent or old haemorrhage. Endometriosis with minimal stroma should be differentiated from invasive adenocarcinoma of the bladder. This case reports demonstrates that endometriosis in bladder although rare should always be ruled out by proper histological examination and save patient from unnecessary overtreatment.
Side Effects of COVID-19 Vaccinations
Authors: Hsu Hsiu-Ling
Published: February 2024

In December 2020, the first COVID-19 vaccinations were granted emergency use permission in the US.1.2 billion vaccination doses have been delivered worldwide. However, some individuals are hesitant to get the COVID-19 vaccine due to safety concerns and unwanted effects. In randomized clinical trials of COVID-19 vaccinations, side effects reported included injection site discomfort, redness, swelling, as well as systemic symptoms such as weariness, headache, muscle or joint pain. Serious adverse events were infrequent. Although the majority of side effects were moderate, research found that 50% to 90% of subjects had them. While government-sponsored reporting systems have provided information on side effects, there is a lack of real-world patient-reported data on those who are more likely to have them after getting the COVID-19 vaccine. The study aimed to detect and report adverse effects related with COVID-19 immunization in an online population. Additionally, the study aimed to uncover variables linked to more severe unfavorable effects. These findings may improve public knowledge of harmful effects from COVID-19 vaccinations.
The Use of Bone Hook in the Retrieval of Tibial Bony Cut. Technical Tip
Authors: Faraj Adnan A
Published: February 2024

Total ankle replacement, is technically demanding. Intraoperative malleolar fracture may result because of levering on the malleoli whilst removing the distal tibial cut. The technique described of using bone hook to retrieve the distal tibial bone cut is safe and easy.