bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance measurement, evaluation and accountability in public philanthropic foundations
Authors: Williamson Alexandra Kate , Kingston Kylie L
Published: March 2021

Philanthropic foundations routinely evaluate and measure the performance of nonprofit organisations to which they distribute funds, as well as the programmes that are funded. Another aspect of philanthropic foundations’ evaluation processes, which receives comparatively little attention within academic or practitioner literature, concerns evaluations of grant applications. While the focus of philanthropic evaluation literature is mainly on ‘how evaluation is done’, the focus of this article is on ‘how evaluation is understood’. This article details perspectives from interviews with 28 managers and trustees of Public Ancillary Funds as part of a wider study on the accountability of foundations. These public foundations must fundraise from the public, and donations to them are deductible against the taxable income of the donor, resulting in a significant element of accountability to the public for their effectiveness and evaluation of the distribution of their funds. Four main themes emerged through the exploration of how evaluation is understood from the perspective of these senior foundation leaders: motivations, values, criteria and processes of evaluation.
The Incidence and Location of Deep Vein Thrombosis in Lower Extremity Fracture Patients Receiving Sequential Chemical Prophylaxis
Authors: Wang Peng-Fei , Zhang Bin-Fei , Xue Hanzhong , Zhuang Yan , Li Zhong , Zhu Yanjun , Zhang Kun , Liu Ping
Published: March 2021

To investigate the incidence and location of deep vein thrombosis (DVT) in patients with lower extremity fractures receiving pharmacological thromboprophylaxis with LMWH followed by rivaroxaban. All patients aged ≥18 years with lower extremity fractures were included in the study. Duplex ultrasonography (DUS) was performed in the lower extremities before and after surgery for DVT evaluation. According to the location, the DVT was divided into proximal, distal, and mixed thromboses. According to fracture location, patients were classified as having fractures proximal, around, and distal to the knee. All patients received sequential chemical prophylaxis. A total of 404 patients with a mean age of 44.2 ± 13.8 years were included. The incidence of DVT postoperatively was higher than that preoperatively and at 1 month postoperatively. Patients with fractures proximal and around the knee had higher DVT incidences detected on DUS postoperatively and at 1 month postoperatively. Most DVTs were located in the distal vein. DVT incidence and severity were the highest immediately after surgery. DVT incidence in fractures around and proximal to the knee increased after surgery and at 1 month postoperatively. Although with chemical thromboprophylaxis, distal DVT was the most variable during the early stage.
Child Protective Services Guidelines for Substantiating Exposure to Domestic Violence as Maltreatment and Assigning Caregiver Responsibility: Policy Analysis and Recommendations
Authors: Victor Bryan G. , Rousson Ashley N. , Henry Colleen , Dalvi Haresh B. , Mariscal E. Susana
Published: March 2021

The purpose of this study was to examine the range of policy approaches used by child welfare systems in the United States to guide workers in classifying and substantiating child exposure to domestic violence (CEDV) as an actionable form of maltreatment. To that end, we conducted a qualitative document analysis of child protective services (CPS) policy manuals from all state-administered child welfare systems in the U.S. ( N = 41). Our findings indicate that a majority of state-administered systems (71%) have adopted policy requiring workers to demonstrate that children have endured harm or the threat of harm before substantiating CEDV-related maltreatment. Many state systems (51%) also include policy directives that require workers to identify a primary aggressor during CPS investigations involving CEDV, while far fewer (37%) provide language that potentially exonerates survivors of domestic violence from being held accountable for failure to protect on the basis of their own victimization. Based on our findings and identification of policy exemplars, we offer a recommended set of quality policy indicators for states to consider in the formulation of their policy guidelines for substantiating children’s exposure to domestic violence that promotes the safety and wellbeing of both children and adult survivors of domestic violence.
Memory Complaints in Healthy Middle-Aged Adults Are Not Associated with Memory or Sustained Attention Performance
Authors: Quek Yi-En , Leuar Kok Hon , Saling Michael M. , Johnson Katherine A.
Published: March 2021

Objective:

To examine the associations between the number and type of memory complaints with memory and sustained attention performance in healthy middle-aged adults.

Method:

Sixty-six healthy individuals aged 35–64 years ( Mage = 47.73 years) were administered the seven Questions, Rey Auditory Verbal Learning Test, Sustained Attention to Response Task, and Depression Anxiety Stress Scales 21.

Results:

The number of memory complaints was not associated with memory or sustained attention performance but was associated with anxiety symptoms. The type of memory complaint was likewise not associated with memory or sustained attention performance. The complaints “recent change in ability to remember things” and “trouble remembering things from one second to the next” were associated with anxiety symptoms.

Conclusion:

Complaints about memory in otherwise healthy middle-aged adults do not reliably indicate memory or sustained attention performance. Rather, these complaints are more likely to be associated with heightened, but nevertheless subclinical, anxiety.
Cervicothoracic Neurenteric Cyst With Contralateral Diaphragmatic Hernia: An Unusual Combination
Authors: Worrell Stephanie , Randall Alice , O'Donnell Brighid
Published: March 2021

We describe a premature male infant who died from complications resulting from two malformations: a large left-sided diaphragmatic hernia and a right-sided cervicothoracic neurenteric cyst. The findings of the first limited prenatal ultrasound led to the incorrect diagnosis of right-sided diaphragmatic hernia. Vertebral anomalies, commonly associated with neurenteric cysts, and an intrathoracic stomach, were not identified until autopsy examination. A literature review describes only one partly similar case relating a neurenteric cyst to the jejunum associated with an ipsilateral diaphragmatic defect identified on prenatal ultrasound. The second report of this combination raises the question of a developmental relationship.
Chronic paronychia in cats with patellar fracture and dental anomaly syndrome
Authors: Pilot Mariette A , Bell Cynthia , O’Dair Hilary , Glenn Ellen J , Bailey Steven , Langley-Hobbs Sorrel J
Published: March 2021

Case series summary

The aim of this case series was to describe the clinical features and treatment of paronychia in cats diagnosed with patellar fracture and dental anomaly syndrome (PADS). Clinical records, photographs, microbiology, cytology and histopathology reports were collected, and follow-up was obtained. Five cats with paronychia were included. All five cats had multiple digits of multiple limbs affected and eventually underwent amputation of the third phalanx of one or multiple digits. A total of 36 digits were affected, 17% (n = 6/36) resolved with medical management and 83% (n = 30/36) were eventually treated successfully by amputation. The cats had treatment with numerous courses of antibiotics (range 7–20; mean 11 courses) over periods of time ranging from 10 to 67 months (mean 32 months).

Relevance and novel information

Chronic paronychia may be an additional clinical feature of PADS and the probable mechanism involves poor integrity of osteopetrotic bone, loss of normal nailbed anatomy and secondary osteomyelitis of the distal phalanx. Medical management with antibiotics, anti-inflammatory therapy and steroid treatment may improve the clinical signs in the short term; however, in severe instances, amputation of the third phalanx of the affected digit seems to be necessary to resolve repeated recurrences and discomfort. Additional information on the long-term outcome is required. In any cat with atraumatic patellar fractures and/or retained deciduous teeth, paronychia may require surgical management if medical management is unsuccessful.
ICT adoption and tourism consumption among rural residents in China
Authors: Zhu Zhongkun , Ma Wanglin , Leng Chenxin
Published: March 2021

Little is known about the tourism consumption of the rural population in developing and emerging countries. This note fills the gap by investigating how information and communication technology (ICT) adoption influences tourism participation decisions and expenditure of rural residents in China. We estimate the data of 11,000 samples from the China Labor-force Dynamic Survey data, using both recursive bivariate probit and treatment effects models. Findings reveal that ICT adoption increases the probability of tourism participation among rural Chinese residents by 18.6% but decreases the expenditure of tourism participants by 442 Yuan/capita on average. We also show that ICT adoption empowers rural women for tourism consumption. Our findings highlight the importance of improving the rural ICT infrastructure and promoting ICT adoption among rural residents to boost rural tourism consumption and social welfare.
From training wheels to chemical condoms: Exploring narratives of PrEP discontinuation
Authors: Garcia Iglesias Jaime
Published: March 2021

This paper explores experiences of PrEP, a HIV-prevention intervention, among bugchasers, gay men who eroticize HIV. While PrEP has been hailed as a “game changer” in HIV-prevention, little attention has been paid to why and how some people may discontinue it in the face of HIV risk, such as bugchasers do. This paper relies on interview data with bugchasers themselves to discuss the process of discontinuation and its effects. The paper argues that, for these men, discontinuation is a fluid, complex, and sometimes contradictory process. It also describes how participants perceived themselves as being at different stages of discontinuation. The paper also analyzes how these men see PrEP as a barrier to intimacy, risk, and a tool to negotiate their desires and identity: through discontinuing PrEP, these men are able to reflect on and build their identities as bugchasers.
Experiences of Family Burden in Caring for the Severely Mentally Ill in a Foreign Land: A Qualitative Study of Chinese Immigrant Families in Toronto, Canada
Authors: Law Samuel , Andermann Lisa , Chow Wendy , Luo Xing Wei , Wang Xiang
Published: March 2021

There is a relative dearth of qualitative studies on the actual experiences of families caring for members suffering from serious mental illness, and even less is known about disadvantaged ethnic minority immigrant families. This explorative qualitative study examines the burden experienced by 15 family members of Chinese immigrant background in Toronto, Canada. Six common themes emerged from the study: 1) significant worries about not being able to take care of ill members in the future; 2) on-going strain and changed family life; 3) pervasive social stigma, discrimination and lack of resources; 4) general appreciation of Canadian health and welfare systems and opportunities; 5) cultural factors and beliefs uniquely shape families’ support and caring commitment; and 6) families find various ways to cope and help themselves. Opportunities for improved care delivery based on these understandings are discussed.
COVID-19 and European carcerality: Do national prison policies converge when faced with a pandemic?
Authors: Zeveleva Olga , Nazif-Munoz José Ignacio
Published: March 2021

The article analyses an original dataset on policies adopted in 47 European countries between December 2019 and June 2020 to prevent coronavirus from spreading to prisons, applying event-history analysis. We answer two questions: 1) Do European countries adopt similar policies when tackling the COVID-19 pandemic in prisons? 2) What factors are associated with prison policy convergence or divergence? We analyze two policies we identified as common responses across prisons around the world: limitations on visitation rights for prisoners, and early releases of prisoners. We found that all states in our sample implemented bans on visits, showing policy convergence. Fewer countries (16) opted for early releases. Compared to the banning of visitation, early releases took longer to enact. We found that countries with prison overcrowding problems were quicker to release or pardon prisoners. When prisons were not overcrowded, countries with higher proportions of local nationals in their prisons were much faster to limit visits relative to prisons in which the foreign population was high. This research broadens our comparative understanding of European carcerality by moving the comparative line further East, taking into account multi-level governance of penality, and analyzing variables that emphasize the ‘society’ element of the ‘punishment and society’ nexus.
Breathing places: Three filmmaking investigations
Authors: Rogers Christine , Gough-Brady Catherine , Berry Marsha
Published: March 2021

Filmmakers and scholars Christine Rogers, Catherine Gough-Brady, and Marsha Berry each find a connection with place through their video work. In this article, they share their experiences of creating short videos, focusing on their insider experiences of filming and the spatial relationships between themselves and place. Although each of them began with a proposition, they filmed unscripted, allowing themselves to respond intuitively to their environment, allowing space in their practices for fluid and organic change and letting place shape what they filmed, and their final works.

Christine Rogers engages with Elspeth Probyn’s idea of belonging as movement as she films Ngāi Tahu (Māori) traveling in dinghies away from her, toward islands where she, an outsider, cannot set foot. Catherine Gough-Brady finds a connection between non-representational theory and documentary film theory, uncovering a landscape that has no eye-line. Marsha Berry explores the seaside landscape, making a constellation with Rebecca Solnit’s lyrical essays about walking and place and non-representational theory as a mooring for her practice, exposing the common experience of standing still whilst looking at the blue horizon at sunset. Each filmmaker finds a unique path through the myriad of elements that make something a place.
Supporting Health Care Staff With Family Meals During the COVID-19 Pandemic
Authors: Utter Jennifer , McCray Sally
Published: March 2021

Family meals provide a unique opportunity for families to eat well and engage positively with each other. In response to the challenges presented by the COVID-19 (coronavirus disease 2019) pandemic, a new initiative to support health care staff to share healthy meals with their families was developed. At a hospital in Queensland, Australia, dietetic staff collaborated with the on-site food service retailer to develop and offer a range of hot meals that staff could take home for their families at the end of their day. The meals were nutritious, reasonably priced, and designed to feed a family of four. The dietetic staff worked with the hospital marketing department and staff health and wellness program to promote the initiative. Over the 3 months that it has been running, nearly 300 meals have been purchased. Anecdotal comments from the food service retailer highlighted that the initiative was a good thing to do for staff to maintain a positive reputation of the business. The staff evening meal initiative is a healthy, affordable, educational, and socially engaging alternative to takeaway meals and food delivery by app, and it is mutually beneficial for health care staff and the on-site food retailer. The initiative also offers a unique opportunity for promoting nutrition and social engagement during stressful times.
Giant Epidermoid Cyst of Posterior Fossa—Our Experience and Literature Review
Authors: Spinato Giacomo , Gaudioso Piergiorgio , Falcioni Maurizio , Mosto Maria Cristina Da , Cocuzza Salvatore , Maniaci Antonino , Fabbris Cristoforo , Politi Doriano , Volo Tiziana , Ferri Emanuele , Cristalli Giovanni , Mannelli Lorenzo , Salvatore Marco , Rizzo Paolo Boscolo , Frezza Daniele
Published: March 2021

Introduction. Intracranial epidermoid cysts are the most frequent congenital intracranial lesion. They rare and benign tumors that can present in different clinical situations depending on location and extension of the disease. Diagnosis is obtained with radiological imaging with RM and non-enhanced TC as elective investigating methods. Elective treatment is surgery, based on total/subtotal excision sparring healthy neurovascular structures, considering the benign nature of this lesion. Case Report. In this study we present the case of a 79-year-old woman affected by recidivist epidermal cyst of the posterior fossa. Clinical presentation was characterized by positional subjective vertigo, intense headache localized in the right part of the head increased by Valsalva maneuver and retroarticular subcutaneous swelling. Radiological investigation found a giant epidemoid cyst of the posterior fossa (8,4 x 4,8 x 5,8 cm), treated with surgery. In the postoperative, the patient was fine and no neurological deficit has been encounterd. REVIEW. In this study, we present a review of the literature regarding giant epidermoid cysts of posterior fossa. Only 11 cases were reported before ours, which actually is one of the largest ever described.
A Review of Approaches, Strategies and Ethical Considerations in Participatory Research With Children
Authors: Montreuil Marjorie , Bogossian Aline , Laberge-Perrault Emilie , Racine Eric
Published: March 2021

Participatory research can change the view of children from research subjects to active partners. As active partners, children can be recognized as agents who can contribute to different steps of the research process. However, “participatory research” is an umbrella term that covers both the collection of data with children and children’s participation in making decisions related to the research process. As such, it raises particular challenges for researchers. Based on a pragmatic ethics approach, we were inspired by the realist review methodology to synthesize the current literature, identify different strategies used to engage children aged 12 and below in participatory research, and analyze how they affect children’s active participation and the ethical aspects related to each. Fifty-seven articles were retained for inclusion in the review. A variety of strategies were used to involve children in the research process, including discussion groups, training/capacity-building sessions, photography and filming, children as data collectors and questionnaires. The most prevalent ethical considerations identified were related to power dynamics and strategies to facilitate children’s expression and foster the authenticity of children’s voices. Researchers should address these ethical considerations to actively involve children within the research process and prevent tokenistic participation. Active inclusion of children in research could include co-identifying with them how they want to be involved in knowledge production (if they want to) from the beginning of a project.
Boosting nationalism through COVID-19 images: Multimodal construction of the failure of the ‘dear enemy’ with COVID-19 in the national press
Authors: Martikainen Jari , Sakki Inari
Published: March 2021

Using a multimodal discursive approach, this study explores how the COVID-19 pandemic is constructed and used in press reportage to mobilize intergroup relations and national identities. We examine how press reporting about the development of COVID-19 in Sweden is cast as a matter of nationalism and national stereotyping in the Finnish press. The data consist of 183 images with accompanying headlines and captions published in two Finnish national newspapers between January 1 and August 31, 2020. We found three multimodal rhetorical strategies of stereotyping: moralizing, demonizing, and nationalizing. These strategies construct discourses of arrogant, immoral, and dangerous Swedes sourcing from national stereotypes. The study contributes to current knowledge about the work on national stereotypes by illustrating how they are used in media discourse to achieve certain rhetorical ends, such as to persuade, mitigate, or justify intergroup relations. Furthermore, the study offers insight into the multimodal constructions and functions of stereotypes.
Aflibercept or bevacizumab in combination with FOLFIRI as second-line treatment of mRAS metastatic colorectal cancer patients: the ARBITRATION study protocol
Authors: Ottaiano Alessandro , Scala Stefania , Santorsola Mariachiara , Trotta Anna Maria , D’Alterio Crescenzo , Portella Luigi , Clemente Ottavia , Nappi Anna , Zanaletti Nicoletta , De Stefano Alfonso , Avallone Antonio , Granata Vincenza , Notariello Carmen , Luce Amalia , Lombardi Angela , Picone Carmine , Petrillo Antonella , Perri Francesco , Tatangelo Fabiana , Di Mauro Annabella , Albino Vittorio , Izzo Francesco , Rega Daniela , Pace Ugo , Di Marzo Massimiliano , Chiodini Paolo , De Feo Gianfranco , Del Prete Paola , Botti Gerardo , Delrio Paolo , Caraglia Michele , Nasti Guglielmo
Published: March 2021

Background:

The intensive study of predictive factors has strongly ameliorated the therapeutic flow-chart of metastatic colorectal cancer (mCRC) by allowing the selection of patients who benefit from specific therapies. For instance, in mRAS (mutated RAS) mCRC patients, anti-EGFR drugs (cetuximab and panitumumab) are not recommended; in this group of patients, the use of anti-angiogenic drugs (bevacizumab and aflibercept) is predominant. However, at progression to standard bevacizumab-based first-line chemotherapy, still to date, there are no studies to guide oncologists in the choice of the best second-line anti-angiogenic drug (bevacizumab beyond progression versus aflibercept).

Methods:

ARBITRATION is a prospective, observational study assessing efficacy differences between second-line fluorouracil/irinotecan (FOLFIRI)/bevacizumab versus FOLFIRI/aflibercept at progression to fluoropyrimidines, oxaliplatin and bevacizumab in mRAS mCRC patients. A test power of 80%, a median survival of 9 months from second-line treatment start and a hazard ratio of 0.67 between the two schedules were the basis for statistical design. The final sample will be 220 patients (110 per treatment). The significance will be verified with a two-tailed log-rank test with an alpha value of the I-type error of 5%. Time-to-outcome will be described by Kaplan–Meier curves and prognostic factors studied through multivariable analyses based on the Cox model. Secondary objectives include safety, responses’ duration and progression-free survival. A translational research will be conducted to measure several angiogenic proteins in patients’ serum before starting the therapy in order to evidence any angiogenic factor patterns related to outcome.

Discussion:

We present a large, prospective, observational study aiming to answer two scientific questions: (1) outcome differences between second-line treatments with FOLFIRI/bevacizumab beyond progression versus FOLFIRI/aflibercept in mRAS mCRC patients, (2) angiogenic factors’ patterns that could associate with efficacy and help oncologists to apply best the therapeutic anti-angiogenic strategies.

Trial registration:

The ARBITRATION trial (version 0.0, 13 April 2020) has been registered into the clinicaltrials.gov registry on 20 May 2020 with identifier NCT04397601.
Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer
Authors: Magios Nikolaus , Bozorgmehr Farastuk , Volckmar Anna-Lena , Kazdal Daniel , Kirchner Martina , Herth Felix J. , Heussel Claus-Peter , Eichhorn Florian , Meister Michael , Muley Thomas , Elshafie Rami A. , Fischer Jürgen R. , Faehling Martin , Kriegsmann Mark , Schirmacher Peter , Bischoff Helge , Stenzinger Albrecht , Thomas Michael , Christopoulos Petros
Published: March 2021

Background:

Epidermal growth factor receptor-mutated (EGFR+) non-small-cell lung cancer (NSCLC) patients failing tyrosine kinase inhibitors (TKI) can benefit from next-line targeted therapies, but implementation is challenging.

Methods:

EGFR+ NSCLC patients treated with first/second-generation (1G/2G) TKI at our institution with a last follow-up after osimertinib approval (February 2016), were analyzed retrospectively, and the results compared with published data under osimertinib.

Results:

A total of 207 patients received erlotinib (37%), gefitinib (16%) or afatinib (47%). The median age was 66 years, with a predominance of female (70%), never/light-smokers (69%). T790M testing was performed in 174/202 progressive cases (86%), positive in 93/174 (53%), and followed by osimertinib in 87/93 (94%). Among the 135 deceased patients, 94 (70%) received subsequent systemic treatment (43% chemotherapy, 39% osimertinib), while 30% died without, either before (4%) or after progression, due to rapid clinical deterioration (22%), patient refusal of further therapy (2%), or severe competing illness (2%). Lack of subsequent treatment was significantly (4.5x, p < 0.001) associated with lack of T790M testing, whose most frequent cause (in approximately 50% of cases) was also rapid clinical decline. Among the 127 consecutive patients with failure of 1G/2G TKI started after November 2015, 47 (37%) received osimertinib, with a median overall survival of 36 months versus 24 and 21 months for patients with alternative and no subsequent therapies ( p = 0.003).

Conclusion:

Osimertinib after 1G/2G TKI failure prolongs survival, but approximately 15% and 30% of patients forego molecular retesting and subsequent treatment, respectively, mainly due to rapid clinical deterioration. This is an important remediable obstacle to sequential TKI treatment for EGFR+ NSCLC. It pertains also to other actionable resistance mechanisms emerging under 1G/2G inhibitors or osimertinib, whose rate for lack of next-line therapy is similar (approximately 35% in the FLAURA/AURA3 trials), and highlights the need for closer monitoring alongside broader profiling of TKI-treated EGFR+ NSCLC in the future.
Menstrual related discomfort and associated factors among undergraduate students in Ambo University, Central Ethiopia
Authors: Yirsaw Mesenbet Terefe , Wale Mengistu Zelalem
Published: March 2021

Background:

Menstruation is a natural phenomenon which is an indicator of women’s health that occurs throughout the reproductive years of every female. This phenomenon is unique to the females and governed by the girl’s general health condition, genetic, socioeconomic, and nutritional factors. Although it is a normal physiological process, most females experience some degree of pain and discomfort in their menstruation period. Even though there are limited studies so far reported about the issue in some other parts of the country, there is no scientific evidence in the present study area.

Objective:

To assess menstrual-associated discomfort and associated factors among undergraduate students in Ambo University, Central Ethiopia, 2018.

Methods:

Institution-based cross-sectional study was conducted at Ambo University from 30 March to 30 April 2018. Stratified sampling technique was used and 748 study participants were randomly selected from faculties using a multi-stage sampling procedure. Only data from 713 study participants were entered into EpiData 3.1 and analyzed using SPSS version 20.0 software. Logistic regression was used to associate factors with menstrual-associated discomfort. All statistical tests were considered as significant at a p-value of < 0.05.

Result:

The prevalence of menstrual-associated discomfort was found to be 68.6%. The variables age (Being younger) (adjusted odds ratio = 3.9 (95% confidence interval: 1.28, 11.78)), Tigire ethnicity (adjusted odds ratio = 2.4 (95% confidence interval: 1.02, 5.75)), unmarried (adjusted odds ratio = 2.1 (95% confidence interval: 1.21, 3.76)), smokers (adjusted odds ratio = 2.2 (95% confidence interval: 1.12, 4.29)), drinking caffeine (adjusted odds ratio = 1.8 (95% confidence interval: 1.17, 2.74)), amount of flow (adjusted odds ratio = 2.4 (95% confidence interval: 1.28, 4.62)), and duration of pain (adjusted odds ratio = 4.2 (95% confidence interval: 1.93, 9.29)) were significantly associated with menstrual-associated discomfort.

Conclusion:

This study revealed that majority of the participants was experienced with menstrual-associated discomfort. As the tendency of smoking cigarettes, drinking caffeine, and amount of flow is increased, menstrual associated discomfort is increased. Therefore, specific plan of action and support is urgently needed in order to enlighten and treat menstrual-associated discomfort.
Memory as the Aspatial Domain for the Perception of Certain Genres of Contemporary Art Music
Authors: Wanke Riccardo , Santarcangelo Vincenzo
Published: March 2021

This paper enquires into the nature of the connections between memory and certain genres of contemporary art music whose unique features rely particularly on our early mnemonic processes. Specific sound configurations of this music are often associated, during listening, with visual and tactile sensorial qualities and with abstract geometries. They are perceived fundamentally as the results of acoustic-physical forces and energies and are organized according to Gestalt and kinesthetic principles. This kind of music calls for a specific listening attitude, which we define as the vertical stance, and seems particularly apt to respond to mechanisms of the working memory where echoic, short- and long-term memories assume a central role. In this vertical stance, memory is involved in the mental construction (segregation, storage, and prediction) of the Gestalt configurations of this music within a perceptual domain that crucially has no spatial connection to the external world. In tying in neurophysiological and psychological research with musicological theories, we discuss the perceptual approach to these music practices in the light of the philosophical concept of the ‘No-Space world’ as conceived by the philosopher Peter Strawson. We propose that – under certain conditions – memory may be the realm of the purely spectro-temporal features of music. The sound configurations of this music in particular are part of an internal-external perceptual framework, being decoded in the conceptual space of perception and able to elicit high-order recollections typical of an embodied engagement with the external world.
Racing for Representation: A Visual Content Analysis of North American Running Magazine Covers
Authors: Seyidoglu Jenna , Roberts Candace , Darroch Francine , Hillsburg Heather , Schneeberg Amy , McGettigan-Dumas Roisin , Huddle Molly , Montaño Alysia
Published: March 2021

The covers of running magazines are powerful ideological tools, and the individuals featured on covers shape broader public perception of who belongs in running. To examine representation, this study analyzed 285 images of athletes on the covers of three popular North American running magazines over an 11-year period (2009–2019). Through a visual content analysis of cover photos and the use of intersectional feminist theory as a framework, we found disparity in the representation of racialized athletes in comparison to non-racialized athletes, as well as an overrepresentation of female athletes in comparison to their male counterparts. We argue that in order to challenge dominant understandings of who can rightfully and safely participate in running, it is essential to increase the images of racialized people on magazine covers.
Recoiling From Threat: Anxiety Is Related to Heightened Suppression of Threat, Not Increased Attention to Threat
Authors: Kappenman Emily S. , Geddert Raphael , Farrens Jaclyn L. , McDonald John J. , Hajcak Greg
Published: March 2021

Increased attention to threat is considered a core feature of anxiety. However, there are multiple mechanisms of attention and multiple types of threat, and the relationships among attention, threat, and anxiety are poorly understood. In the present study, we used event-related potentials (ERPs) to separately isolate attentional selection (N2pc) and suppression (PD) of pictorial threats (photos of weapons, snakes, etc.) and conditioned threats (colored shapes paired with electric shock). In a sample of 48 young adults, both threat types were initially selected for increased attention (an N2pc), but only conditioned threats elicited subsequent suppression (a PD) and a reaction time (RT) bias. Levels of trait anxiety were unrelated to N2pc amplitude, but increased anxiety was associated with larger PDs (i.e., greater suppression) and reduced RT bias to conditioned threats. These results suggest that anxious individuals do not pay more attention to threats but rather engage more attentional suppression to overcome threats.
The effect of Allium cepa extract on the chitosan/PLGA scaffolds bioactivity
Authors: Monárrez-Cordero Blanca Elizabeth , Rodríguez-González Claudia Alejandra , Valencia-Gómez Laura Elizabeth , Hernández-Paz Juan Francisco , Martel-Estrada Santos Adriana , Camacho-Montes Héctor , Olivas-Armendáriz Imelda
Published: March 2021

Allium cepa extracts (AC) allow the fabrication of a biomaterial that, together with chitosan and PLGA, could be osteoconductive and promote a better and faster regeneration of bone tissue, with biocompatibility and biomineralization properties. In this work, scaffolds were developed by the thermally induced phase separation (TIPS) technique. An in vitro bioactivity analysis was performed using simulated body fluid (SBF). Scanning electron microscopy (SEM), energy dispersion spectroscopy, and infrared spectroscopy were used for the scaffolds characterization. The results showed a structure with a pore size distribution between 50 and 100 μm, which allowed the uniform formation of biological apatite crystals on the surface of the scaffolds. The chitosan/policaprolactone/ Allium cepa scaffold (ChPAC) showed the most promising results with a ratio of P/Ca between 1.6 and 1.7, a value very close to that of hydroxyapatite.
Onco-hypertension: Overview of hypertension with anti-cancer agents
Authors: Ruf Rebecca , Yarandi Niloufarsadat , Ortiz-Melo David I , Sparks Matthew A
Published: March 2021

Onco-hypertension is an emerging field investigating the relationship between hypertension and cancer. This paper details one part of this relationship—the effect of anti-cancer agents on blood pressure. We review the evidence linking targeted therapies, immunotherapy, traditional chemotherapies, and hormonal agents with hypertension. Proposed pathophysiological mechanisms vary by drug but include endothelial dysfunction, altered sodium homeostasis, and nephrotoxicity. Despite growing interest in the field, there is a paucity of data on the clinical significance of treatment related hypertension and the optimal management strategy. This should be a focus of future studies.
Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding
Authors: Nešić Dragana , Bush Martin , Spasic Aleksandar , Li Jihong , Kamata Tetsuji , Handa Makoto , Filizola Marta , Walz Thomas , Coller Barry S.
Published: March 2021

The murine monoclonal antibody (mAb) PT25-2 induces αIIbβ3 to bind ligand and initiate platelet aggregation. The underlying mechanism is unclear, because previous mutagenesis studies suggested that PT25-2 binds to the αIIb β propeller, a site distant from the Arg-Gly-Asp–binding pocket. To elucidate the mechanism, we studied the αIIbβ3–PT25-2 Fab complex by negative-stain and cryo-electron microscopy (EM). We found that PT25-2 binding results in αIIbβ3 partially exposing multiple ligand-induced binding site epitopes and adopting extended conformations without swing-out of the β3 hybrid domain. The cryo-EM structure showed PT25-2 binding to the αIIb residues identified by mutagenesis but also to 2 additional regions. Overlay of the cryo-EM structure with the bent αIIbβ3 crystal structure showed that binding of PT25-2 creates clashes with the αIIb calf-1/calf-2 domains, suggesting that PT25-2 selectively binds to partially or fully extended receptor conformations and prevents a return to its bent conformation. Kinetic studies of the binding of PT25-2 compared with mAbs 10E5 and 7E3 support this hypothesis. We conclude that PT25-2 induces αIIbβ3 ligand binding by binding to extended conformations and by preventing the interactions between the αIIb and β3 leg domains and subsequently the βI and β3 leg domains required for the bent-closed conformation.
Establishment and associated factors of health records among young Chinese migrants
Authors: Shi Hong , Zhang Xiumin , Li Xiangrong , Ren Zheng , Zhao Hanfang , He Minfu , Fan Xinwen , Guo Xia , Zha Shuang , Qiao Shuyin , Li Yuyu , Pu Yajiao , Liu Hongjian
Published: March 2021

Background

Most Chinese migrants have been faced with obstacles to getting access to local public health services. Young migrants among internal migrants make a major contribution to the economy. However, the establishment of their health records has been ignored. This research was aimed at exploring the status and associated factors of the establishment of health records among young Chinese migrants.

Methods

Data were obtained from the 2017 China Migrants Dynamic Survey (CMDS). Chi-square test and binary logistic regression were performed to investigate the associated factors of the establishment of health records among young Chinese migrants.

Results

Approximately 30.2% of young migrants had their health records established in inflow communities. Urban residence, medical insurance (insured), and lower average monthly household income were attributed to the establishment of more health records. Young migrants who were in northeast China and across provinces and immigrated for working or engaging in trade were less likely to have health records established. Young migrants who participated in social activities and public affairs activities and took type of people in touch as natives in the inflow area showed a higher possibility of establishing health records. Meanwhile, receiving health education and hearing about national basic public health services (BPHSs) were beneficial for establishing the health records of more young migrants.

Conclusion

This study showed that the health records of young migrants had a relatively low establishment rate. Sociodemographic and migration characteristics, health status, public health services, and social integration factors were all related to the health record establishment of young Chinese migrants.
ModularBoost: an efficient network inference algorithm based on module decomposition
Authors: Li Xinyu , Zhang Wei , Zhang Jianming , Li Guang
Published: March 2021

Background

Given expression data, gene regulatory network(GRN) inference approaches try to determine regulatory relations. However, current inference methods ignore the inherent topological characters of GRN to some extent, leading to structures that lack clear biological explanation. To increase the biophysical meanings of inferred networks, this study performed data-driven module detection before network inference. Gene modules were identified by decomposition-based methods.

Results

ICA-decomposition based module detection methods have been used to detect functional modules directly from transcriptomic data. Experiments about time-series expression, curated and scRNA-seq datasets suggested that the advantages of the proposed ModularBoost method over established methods, especially in the efficiency and accuracy. For scRNA-seq datasets, the ModularBoost method outperformed other candidate inference algorithms.

Conclusions

As a complicated task, GRN inference can be decomposed into several tasks of reduced complexity. Using identified gene modules as topological constraints, the initial inference problem can be accomplished by inferring intra-modular and inter-modular interactions respectively. Experimental outcomes suggest that the proposed ModularBoost method can improve the accuracy and efficiency of inference algorithms by introducing topological constraints.
Biochemical metabolism of young plants of Ucuúba (Virola surinamensis) in the presence of cadmium
Authors: Júnior W. V. Andrade , Neto C. F. Oliveira , Filho B. G. Santos , Cruz E. D. , Amarante C. B. , Barbosa A. V. C. , Nogueira G. A. S. , Nascimento V. R. , Sousa D. J. P. , Teixeira J. S. S.
Published: March 2021

Virola surinamensis is a forest species widely distributed in the estuaries of the Amazon. These ecosystems are susceptible to contamination by Cadmium (Cd), indicating that the plant has strategies for tolerating this metal. The aim of this study was to assess the nitrogen and carbon metabolism of young plants of Ucuúba (Virola surinamensis) in the presence of cadmium with the perspective of the phytoremediation of contaminated environments. The used experimental design was a completely randomized design with five Cd concentrations (0, 15, 30, 45, and 60 mg L− 1), for 60 days. In general, Cd did not affect nitrate concentration in the root but had a positive effect on leaves. The reduction of nitrate reductase (NR) in plants exposed to Cd was followed by a decrease in ammonia, total soluble amino acids (TSA), and total soluble proteins (TSP). Cd promoted an increase in the concentration of total soluble carbohydrates (TSC), proline, sucrose, and reducing sugars in the plants. The increase in TSC, sucrose and proline, suggests a metabolic regulatory mechanism of V. surinamensis against Cd stress.
Prospective study of emergency medicine provider wellness across ten academic and community hospitals during the initial surge of the COVID-19 pandemic
Authors: Kelker Heather , Yoder Kyle , Musey Paul , Harris Madison , Johnson Olivia , Sarmiento Elisa , Vyas Punit , Henderson Brooke , Adams Zachary , Welch Julie
Published: March 2021

Background

While COVID-19 has had far-reaching consequences on society and health care providers, there is a paucity of research exploring frontline emergency medicine (EM) provider wellness over the course of a pandemic. The objective of this study was to assess the well-being, resilience, burnout, and wellness factors and needs of EM physicians and advanced practice providers (e.g., nurse practitioners and physician assistants; APPs) during the initial phase of the COVID-19 pandemic.

Methods

A descriptive, prospective, cohort survey study of EM physicians and APPs was performed across ten emergency departments in a single state, including academic and community settings. Participants were recruited via email to complete four weekly, voluntary, anonymous questionnaires comprised of customized and validated tools for assessing wellness (Well Being Index), burnout (Physician Work Life Study item), and resilience (Brief Resilience Scale) during the initial acceleration phase of COVID-19. Univariate and multivariate analysis with Chi-squared, Fisher’s Exact, and logistic regression was performed.

Results

Of 213 eligible participants, response rates ranged from 31 to 53% over four weeks. Women comprised 54 to 60% of responses. Nonrespondent characteristics were similar to respondents. Concern for personal safety decreased from 85 to 61% (p < 0.001). Impact on basic self-care declined from 66 to 32% (p < 0.001). Symptoms of stress, anxiety, or fear was initially 83% and reduced to 66% (p = 0.009). Reported strain on relationships and feelings of isolation affected > 50% of respondents initially without significant change (p = 0.05 and p = 0.30 respectively). Women were nearly twice as likely to report feelings of isolation as men (OR 1.95; 95% CI 1.82–5.88). Working part-time carried twice the risk of burnout (OR, 2.45; 95% CI, 1.10–5.47). Baseline resilience was normal to high. Provider well-being improved over the four weeks (30 to 14%; p = 0.01), but burnout did not significantly change (30 to 22%; p = 0.39).

Conclusion

This survey of frontline EM providers, including physicians and APPs, during the initial surge of COVID-19 found that despite being a resilient group, the majority experienced stress, anxiety, fear, and concerns about personal safety due to COVID-19, putting many at risk for burnout. The sustained impact of the pandemic on EM provider wellness deserves further investigation to guide targeted interventions.
To be or not to be: relationship between grandparent status and health and wellbeing
Authors: Lai Daniel W. L. , Li Jia , Bai Xue
Published: March 2021

Background

It is common for older people to become grandparents in later life. However, the impacts of grandparenting on their health and well-being remain ambiguous, especially in Chinese society, where the family is in the core of culture. The current study explored the relationship between grandparenthood and Chinese older people’s health and psychological well-being in Hong Kong.

Methods

Cross-sectional data were collected from a sample of 1208 Hong Kong Chinese older people aged 55 and above through a telephone survey conducted in 2019. Participants were grouped into three categories: current grandparents (n = 507), grandparents-to-be (n = 275), and grandparents-not-to-be (n = 426). Multivariate linear regressions were performed to examine the relationship between grandparenting status and health and well-being outcomes, including self-rated physical health, mental health, resilience, and happiness. The potential moderating roles of older adults’ demographic characteristics, including age, sex, education, marital status, financial status, were also examined.

Results

Bivariate analyses suggested statistically significant differences between health and well-being across the three groups of participants. Regression models showed that, compared with grandparents-not-to-be, being a current grandparent was associated with a significantly higher happiness level. Being a future grandparent was associated with significantly higher levels of happiness, resilience, and self-rated physical health. Moderating analyses showed that age, marital status, and educational level could moderate the relationship between grandparent status and resilience and self-rated mental health.

Conclusions

The current study offers preliminary insights into the significant relationship between grandparenthood and older adults’ health and well-being. It calls for future studies to further explore the mechanisms between grandparenthood and the healthy ageing of different subgroups of older adults.