bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of fixation disengagement in the parallel programming of sequences of saccades
Authors: McSorley Eugene , Gilchrist Iain D. , McCloy Rachel
Published: September 2019

One of the core mechanisms involved in the control of saccade responses to selected target stimuli is the disengagement from the current fixation location, so that the next saccade can be executed. To carry out everyday visual tasks, we make multiple eye movements that can be programmed in parallel. However, the role of disengagement in the parallel programming of saccades has not been examined. It is well established that the need for disengagement slows down saccadic response time. This may be important in allowing the system to program accurate eye movements and have a role to play in the control of multiple eye movements but as yet this remains untested. Here, we report two experiments that seek to examine whether fixation disengagement reduces saccade latencies when the task completion demands multiple saccade responses. A saccade contingent paradigm was employed and participants were asked to execute saccadic eye movements to a series of seven targets while manipulating when these targets were shown. This both promotes fixation disengagement and controls the extent that parallel programming can occur. We found that trial duration decreased as more targets were made available prior to fixation: this was a result both of a reduction in the number of saccades being executed and in their saccade latencies. This supports the view that even when fixation disengagement is not required, parallel programming of multiple sequential saccadic eye movements is still present. By comparison with previous published data, we demonstrate a substantial speeded of response times in these condition (“a gap effect”) and that parallel programming is attenuated in these conditions.
Comparative clinical and cost analysis between surgical and non-surgical intervention for knee osteoarthritis
Authors: Mahendira Luxme , Jones Caroline , Papachristos Angelo , Waddell James , Rubin Laurence
Published: September 2019

Objective

To evaluate the management and costs of osteoarthritis of the knee (OAK), a progressive joint disease due to bone and cartilage degeneration, with significant personal and societal impact.

Methods

We prospectively analyzed the clinical outcomes and quantifiable cumulative direct costs of patients with OAK referred to our multidisciplinary OA program over a two year time period. One hundred thirty-one subjects were assessed. All demonstrated radiographic criteria for moderate to severe OAK. Western Ontario McMaster Osteoarthritis Index (WOMAC), Minimal Clinically Important Improvement (MCII), and change in BMI were recorded and analyzed. Total medical and surgical direct costs for all subjects during the two year time period were determined.

Results

Five patients underwent total joint replacement during the two years of study. Among the group as a whole, a significant overall improvement in WOMAC scores was noted at the two year time point follow-up. After dividing the group into tertiles by baseline WOMAC scores, 46% achieved MCII. Significant weight loss was noted for individuals with baseline BMI of > 30. As all patients were considered “de facto” surgical candidates at referral, an average net savings of $9551.10 of direct costs per patient, or a potential total of $1,203,438.60 for the entire group, could be inferred as a result of medical as opposed to surgical management.

Conclusion

These findings support the benefits of multidisciplinary medical management for patients with significant OAK. This approach is clinically beneficial and may provide significant cost savings. Such models of care can substantially improve the long-term outcome of this highly prevalent condition and reduce societal and financial burdens.
Printing a Three‐Dimensional Patient‐Specific Safety Device for Reducing the Potential Risk of Mental Nerve Injury During Transoral Thyroidectomy
Authors: Yeh Yi‐Ting , Chen Jui‐Yu , Kuo Po‐Chung , Wang Tien‐Hsiang , Lee Hsin‐Chen , Chi Chin‐Wen , Lee Chen‐Hsen , Shyr Yi‐Ming , Wang Shyh‐Jen , Chen Wei‐Ming
Published: September 2019

Background

Thyroidectomy transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a safe and cosmetically appealing alternative for well‐selected patients undergoing thyroidectomy. However, during TOETVA, placement of the two lateral trocars and/or manipulation of the surgical instruments through the trocars may potentially injure and/or compress the mental nerve (MN) because the actual location of the nerve foramen may vary among individuals. The MN injury rate was reported to be as high as 75% in the initial period of robotic‐assisted TOETVA. To reduce the potential risk of MN injury, we implemented a three‐dimensional printing technology to develop a safety device for TOETVA.

Methods

The patient‐specific safety device (PSSD) was a brace with an exact fit to the lower teeth and two safety markers on each side to indicate the location of the mental foramen. For patient in whom the brace would not be applicable, a 3D mandibular model was printed as a PSSD instead. We analyzed 66 patients undergoing TOETVA at our institution from March 2017 to March 2019. The preoperative details and complication profiles were also analyzed.

Results

With incorporation of the PSSD into our TOETVA procedure, there have been no cases of MN injury.

Conclusions

Our own TOETVA series has demonstrated that the implementation of the PSSD has been successful in preoperatively identifying and preventing the potential risk of MN injury. Although the additional requirements of preoperative CT and time for fabricating the device impose limitations, the influence of the PSSD in TOETVA is positive.
Surgical Resection of Pheochromocytomas and Paragangliomas is Associated with Lower Cholesterol Levels
Authors: Good Meghan L. , Malekzadeh Parisa , Ruff Samantha M. , Gupta Shreya , Copeland Amy , Pacak Karel , Nilubol Naris , Kebebew Electron , Patel Dhaval
Published: September 2019

Background

Catecholamine excess in patients with pheochromocytomas or paragangliomas (PPGLs) can lead to hypertension, diabetes and hyperlipidemia. The aim was to investigate the prevalence of hyperlipidemia and the effect of surgical resection.

Methods

One hundred and thirty‐two patients with PPGLs underwent an operation at the National Institutes of Health from 2009 to 2016, of which 54 patients met the inclusion criteria. Clinical demographics, BMI, genetic mutations, tumor size, perioperative catecholamine levels and perioperative lipid panels were retrospectively reviewed. Spearman correlation between catecholamines and lipid levels was evaluated. Paired Wilcoxon and paired t test were used to analyze differences in pre‐ and postoperative lipid levels.

Results

Preoperatively, 51 patients (94.4%) had elevated catecholamines, thirteen (24.1%) had elevated total cholesterol (TC) (>200 mg/dL), nine (16.6%) had elevated LDL (>130 mg/dL) and ten (18.5%) had elevated triglycerides (>150 mg/dL). Serum and urinary metanephrine levels were positively associated with TC (r = 0.2792, p = 0.0372 and r = 0.4146, p = 0.0031, respectively) and LDL levels (r = 0.2977, p = 0.0259 and r = 0.4434, p = 0.0014, respectively). Mean TC decreased from 176.4 to 166.3 mg/dL (p = 0.0064) and mean HDL decreased from 56.7 to 53.2 mg/dL (p = 0.0253) after PPGL resection (median 3.1 months (range 1.3–50.2) between lipid panels). Most patients with elevated TC (76.9%) had improvement with mean TC decreasing from 225 to 200.2 mg/dL (p = 0.0230). Of patients with elevated LDL, 66.7% had improvement with mean LDL decreasing from 149 to 131.1 mg/dL (p = 0.0313).

Conclusions

The prevalence of hyperlipidemia in patients with PPGLs is 46%. Future prospective studies are needed to determine whether surgical resection improves TC and/or LDL levels.
Fracture and mode mixity analysis of shear deformable composite beams
Authors: Kiss Balázs , Szekrényes András
Published: September 2019

To analyse delaminated composite beams with high accuracy under mixed-mode I/II fracture conditions first-, second-, third- and Reddy’s third-order shear deformable theories are discussed in this paper. The developed models are based on the concept of two equivalent single layers and the system of exact kinematic conditions. To deduce the equilibrium equations of the linearly elastic system, the principle of virtual work is utilised. As an example, a built-in configuration with different delamination position and external loads are investigated. The mechanical fields at the delamination tip are provided and compared to finite element results. To carry out the fracture mechanical investigation, the J-integral with zero-area path is introduced. Moreover, by taking the advantage of the J-integral, a partitioning method is proposed to determine the ratio of mode-I and mode-II in-plane fracture modes. Finally, in terms of the mode mixity, the results of the presented evaluation techniques are compared to numerical solutions and previously published models in the literature.
Building of Academics’ Networks—An analysis based on Causation and Effectuation theory
Authors: Ahoba-Sam Rhoda , Charles David
Published: September 2019

Individual academic scientists engage in various collaborations through their involvement in both regional and extra-regional networks. However, little is known about how these networks are actually formed. Focusing on university and industry networks, we take the view that the process of building new networks is an entrepreneurial activity that involves unpredictability and often goal ambiguity. This paper thus employs the theories of causation and effectuation to explore how the personal networks of academics are initiated. With evidence from the networks of 12 academics based at the University of Stavanger, Norway we show that both causation and effectuation are employed by academics when building their networks. The usage of causation was found to be more consistent with building industry networks whereas effectuation was employed when building networks in academia. Consequently, effectuation was characteristic of the international networks which were found to be mostly constituted by other academics. On the regional level, a mixture of both approaches of causation and effectuation was observed, with more industry linkages suggesting a tendency to be more causal than effectual. Furthermore, while causation was employed for project level networking, effectuation was employed for establishing more individual level ties.
A Proof of the Bloch Theorem for Lattice Models
Authors: Watanabe Haruki
Published: September 2019

The Bloch theorem is a powerful theorem stating that the expectation value of the U(1) current operator averaged over the entire space vanishes in large quantum systems. The theorem applies to the ground state and to the thermal equilibrium at a finite temperature, irrespective of the details of the Hamiltonian as far as all terms in the Hamiltonian are finite ranged. In this work we present a simple yet rigorous proof for general lattice models. For large but finite systems, we find that both the discussion and the conclusion are sensitive to the boundary condition one assumes: under the periodic boundary condition, one can only prove that the current expectation value is inversely proportional to the linear dimension of the system, while the current expectation value completely vanishes before taking the thermodynamic limit when the open boundary condition is imposed. We also provide simple tight-binding models that clarify the limitation of the theorem in dimensions higher than one.
A systematic review of pharmacists’ interventions to support medicines optimisation in patients with visual impairment
Authors: Kentab Basma Y. , Barry Heather E. , Al-Aqeel Sinaa A. , Hughes Carmel M.
Published: September 2019

Background People with visual impairment often report poorer health and encounter many challenges when using medicines. Pharmacists can play a significant role in optimising medicines use for these patients. However, little is known about pharmacists’ current practices when providing services to this population nor the impact of such services, if any, on medicines optimisation-related outcomes. Aim of the review This systematic review aims to identify the types, and assess the effectiveness of, interventions provided by pharmacists on medicines optimisation-related outcomes. Method Systematic searches of the following electronic databases were carried out from date of inception to March 2018: Cochrane Library; MEDLINE; EMBASE; International Pharmaceutical Abstracts; Scopus; and Cumulative Index to Nursing and Allied Health Literature. Several trial registries and grey literature resources were also searched. Any randomised controlled trials, non-randomised controlled trials, controlled before-and-after studies, or interrupted time series analyses reporting on interventions provided by pharmacists to adult visually impaired patients and/or their caregivers in order to improve medicines optimisation-related outcomes of medicine safety, adherence, patient satisfaction, shared decision making, or quality of life were included. Results A total of 1877 titles/abstracts were screened, and 27 full text articles were assessed for eligibility. On examination of full texts, no studies met the inclusion criteria for this review. Conclusion This review highlights the need for future research that would be vital for promoting the safe and effective use of medicines and the delivery of pharmaceutical care services to people with visual impairment.
Optimal Online Calibration Designs for Item Replenishment in Adaptive Testing
Authors: He Yinhong , Chen Ping
Published: September 2019

The maintenance of item bank is essential for continuously implementing adaptive tests. Calibration of new items online provides an opportunity to efficiently replenish items for the operational item bank. In this study, a new optimal design for online calibration (referred to as D-c) is proposed by incorporating the idea of original D-optimal design into the reformed D-optimal design proposed by van der Linden and Ren (Psychometrika 80:263–288, 2015) (denoted as D-VR design). To deal with the dependence of design criteria on the unknown item parameters of new items, Bayesian versions of the locally optimal designs (e.g., D-c and D-VR) are put forward by adding prior information to the new items. In the simulation implementation of the locally optimal designs, five calibration sample sizes were used to obtain different levels of estimation precision for the initial item parameters, and two approaches were used to obtain the prior distributions in Bayesian optimal designs. Results showed that the D-c design performed well and retired smaller number of new items than the D-VR design at almost all levels of examinee sample size; the Bayesian version of D-c using the prior obtained from the operational items worked better than that using the default priors in BILOG-MG and PARSCALE; and Bayesian optimal designs generally outperformed locally optimal designs when the initial item parameters of the new items were poorly estimated.
Concept for a Gossamer solar power array using thin-film photovoltaics
Authors: Sproewitz Tom , Banik Udayan , Grundmann Jan-Thimo , Haack Frederik , Hillebrandt Martin , Martens Hauke , Meyer Sebastian , Reershemius Siebo , Reininghaus Nies , Sasaki Kaname , Seefeldt Patric , Sergeev Oleg , Spietz Peter , Sznajder Maciej , Toth Norbert , Vehse Martin , Wippermann Torben , Zander Martin E.
Published: September 2019

In recent years, the German Aerospace Center (DLR) developed Gossamer deployment systems in different projects. As power requirements of spacecraft are getting more and more demanding, DLR recently focused on the development of new deployable photovoltaic (PV) technologies that are suitable for generating 10’s of kW per array. Possible space applications that may also require high power supply are missions using electric propulsion such as interplanetary missions, placing of geostationary (GEO) satellites in their orbit or even more future oriented as space tugs or lightweight power generation on extra-terrestrial infrastructures. The paper gives an overview about a feasibility study for flexible solar arrays based on new thin-film photovoltaics. It is expected that the combination of new thin-film PV technologies, e.g., copper indium gallium selenide (CIGS) cells or gallium–arsenide (GaAs) cells, together with Gossamer deployment technologies, could significantly increase the power availability for spacecraft. Based on a requirement, analysis system concepts were evaluated. A focus is on the potential of CIGS PV combined with a two-dimensional deployment of the array and DLR’s coilable carbon fibre-reinforced plastic (CFRP) booms. Therefore, a concept based on crossed booms with a foldable PV membrane is considered as baseline for further developments. The array consists of rectangular PV generators that are interconnected by flexible printed circuit board (PCB) harness. By a double-folding technique, these generators are laid on top of each other in such that the membrane can be extracted from its stowing box during the deployment in a controlled manner. Considering constantly increasing efficiencies of the CIGS PV combined with Gossamer structures, there is clear potential of reaching a very high specific power value exceeding that of conventional PV systems. Furthermore, the CIGS PV appears to be more radiation resistant and has already reached more than 21% efficiency in laboratories. Such efficiencies are expected to be achieved in the near future in a standard manufacturing process. However, flexible, thin-film GaAs cells are also subject of consideration within GoSolAr. With this prospect, DLR’s research has the goal to develop a Gossamer Solar Array (GoSolAr) to exploit the described potential.
Understanding the morphology of MWCNT/PES mixed-matrix membranes using SANS: interpretation and rejection performance
Authors: Nikita Km , Karkare P. , Ray D. , Aswal V. K. , Singh Puyam S. , Murthy C. N.
Published: September 2019

We describe the relationship between the morphology and rejection performance by the mixed-matrix membranes as a unique class of high water flux nanofiltration membranes comprising polyethersulfone/functionalized multiwalled carbon nanotubes (PES/f-MWCNTs). These membranes contain aligned MWCNTs uniformly distributed inside a PES matrix prepared using conventional phase-inversion technique. The small-angle neutron scattering analysis confirmed the high porosity and uniformity among of the pores of CNTs in the membranes. The frictionless water transport from vertically oriented f-MWCNTs were verified to facilitate remarkable enhancement in the water flux through the membranes. The water transportation speed, as well as rejection, of selected heavy metals increases nearly about 3 times and 2–3.5 times, respectively, than the pristine PES membrane, depending upon CNTs loading. Low working pressure and good retention properties make these membranes to be an ideal for the application of highly efficient filtration units.
Impact of Economic Development Levels and Disaster Types on the Short-Term Macroeconomic Consequences of Natural Hazard-Induced Disasters in China
Authors: Tang Rumei , Wu Jidong , Ye Mengqi , Liu Wenhui
Published: September 2019

The relationship between natural hazard-induced disasters and macroeconomic growth has been examined widely on global and national scales, but little research has been focused on the subnational level, especially in China. We examined the impacts of natural hazard-induced disasters on the regional growth in China based on subnational panel data for the period from 1990 to 2016. First, we used the number of people affected and the direct economic losses as the measures of the scale of disasters. Then, we used the direct damages of meteorological disasters and earthquakes as disaster measures separately to examine the impacts of different disaster types. Finally, we performed intraregional effects regressions to observe the spatial heterogeneity within the regions. The results show that the adverse short-term effects of disasters is most pronounced in the central region, while the direct damage of disasters is a positive stimulus of growth in the whole of China. However, this stimulus is observed in a lagged way and is reflected differently—meteorological disasters in central and eastern China and earthquakes in western China are related to regional growth. The results demonstrate that the short-term macroeconomic impacts of these disasters in the three geographical regions of China largely depend on regional economic development levels and the disaster types.
Imaging Manifestations of Acute and Chronic Renal Infection That Mimics Malignancy: How to Make the Diagnosis Using Computed Tomography and Magnetic Resonance Imaging
Authors: Udare Amar , Abreu-Gomez Jorge , Krishna Satheesh , McInnes Matthew , Siegelman Evan , Schieda Nicola
Published: September 2019

Purpose

To review the computed tomography and magnetic resonance imaging manifestations of acute and chronic renal infections that may mimic malignancy and to provide useful tips to establish an imaging diagnosis.

Conclusion

Acute and chronic bacterial pyelonephritis are usually readily diagnosed clinically and on imaging when the diagnosis is suspected based upon clinical presentation. When unsuspected, focal, extensive or mass-like, acute and chronic bacterial pyelonephritis may mimic infiltrative tumours such as urothelial cell carcinoma (UCC), lymphoma, and metastatic disease. Infection may be suspected when patients are young and otherwise healthy when there is marked associated perinephric changes and in the absence of metastatic adenopathy or disease elsewhere in the abdomen and pelvis. Renal abscesses, from bacterial or atypical microbial agents, can appear as complex cystic renal masses mimicking cystic renal cell carcinoma. Associated inflammatory changes in and around the kidney and local invasion favour infection. Emphysematous pyelonephritis can mimic necrotic or fistulizing tumour; however, infection is more likely and should always be considered first. Xanthogranulomatous pyelonephritis can mimic malignancy when focal or multifocal and in cases without associated renal calculi. Malacoplakia is an inflammatory process that may mimic malignancy and should be considered in patients with chronic infection. Bacillus Calmette-Guerin (BCG)-induced pyelonephritis is rare but can mimic renal malignancy and should be considered in patients presenting with a renal mass when being treated with BCG for urinary bladder UCC.
The Comorbidity Between Premature Ejaculation and Erectile Dysfunction—A Cross-Sectional Internet Survey
Authors: Tsai Wei-Kung , Chiang Pai-Kai , Lu Chih-Cheng , Jiann Bang-Ping
Published: September 2019

Introduction

The comorbidity between premature ejaculation (PE) and erectile dysfunction (ED) has not yet been clarified.

Aim

To assess the comorbidity between PE and ED.

Methods

Male members of a shopping club in Taiwan aged 20–60 years with stable sexual relationships were invited to complete an online questionnaire.

Main Outcome Measures

Self-estimated intravaginal ejaculatory latency time (IELT), Premature Ejaculation Diagnostic Tool, Sexual Health Inventory for Men, Self-Esteem and Relationship, and Hospital Anxiety and Depression Scale results were used.

Results

A total of 937 participants with a mean age of 41.1 ± 10.2 years were enrolled. The prevalence rates of ED (Sexual Health Inventory for Men ≤ 21), PE (Premature Ejaculation Diagnostic Tool ≥11), and IELT ≤1 minute were 24.7%, 6.3%, and 6.4%, respectively. Prevalence of acquired PE and IELT ≤1 minute increased marginally with age. Participants with ED had a greater prevalence of PE than those without ED (19.5% vs 2.0%, P < .001), and participants with PE had a greater prevalence of ED than those without PE (76.3% vs 19.4%, P < .001). Compared with participants without PE, participants with PE had greater adjusted odds of ED (odds ratio [OR] = 12.7, 95% CI = 6.7–24.2). Relative to participants without ED, participants with ED had increased adjusted odds of PE (OR = 7.2, 95% CI = 3.5–14.6 with mild ED and OR = 36.7, 95% CI = 16.2–83.0 with ED severity greater than a mild degree). Poor sexual relationships and self-esteem, depression, and anxiety were reported more frequently in those with PE or ED, especially in those with both problems compared with those without PE and ED.

Conclusions

This study confirmed a high prevalence of PE and ED coexistence, indicating a complicated relationship between the 2 conditions and the importance of screening for their co-occurrence in practice.
Kinect Project: People with dementia or mild cognitive impairment learning to play group motion‐based games
Authors: Dove Erica , Astell Arlene J.
Published: September 2019

Introduction

Motion‐based technologies (MBTs) could provide nonpharmacologic interventions for people with cognitive impairment (PCI; e.g., dementia or mild cognitive impairment). This study examined the use of errorless learning techniques to empower PCI to use MBT.

Methods

Thirty‐eight PCI were recruited to a 10‐week (20 × 1‐hour sessions) Xbox Kinect bowling group. Video recorded data from first, middle, and final sessions were coded to track (1) number of prompts per turn, (2) independent turn completion, and (3) duration of turns. These values were compared using repeated measures analysis of variance.

Results

Learning and improvement over time was demonstrated in 23 participants who were available for final analysis by significant decreases in number of prompts per turn and turn duration and significant increases in turns completed independently.

Discussion

Errorless learning supported PCI to learn MBT and improve over time as evidenced by their need for fewer prompts, shorter turns, and more turns completed independently, confirming the potential of MBT to provide leisure activities for PCI.
A Review of Actuation Force in Origami Applications
Authors: Wu S. R. , Chen T. H. , Tsai H. Y.
Published: September 2019

Origami, the ancient paper folding art has inspired the engineering equipment and design for decades. The basic concept of origami is very general, which leads to applications ranging from small scale to large scale. Recently, researchers are interested in being able to create self-folding structures. Such a structure enables kinematic manipulation by external forces or moments without folding and/or unfolding operations. This is a beneficial application for many fields including aerospace systems, robots, small devices and self-assembly systems. In this paper, the investigation and analyses of the previous literatures on the key driving force of the actuation structure, including the heat, light, electricity, gas and other actuation methods. The aims are to provide researchers and practitioners with the support to systematically understand the latest technologies in this important and evolving field, with inspiration and direction for follow-up.
Looking Back at Milošević’s Antibureaucratic Revolution: What Do Ordinary Participants Now Think of Their Involvement?
Authors: Grdešić Marko
Published: September 2019

Most scholarship on Serbia’s antibureaucratic revolution of the late 1980s has emphasized elite actors while ignoring the motivations of ordinary participants. How do ordinary people describe their involvement? Moreover, given the antibureaucratic revolution’s dark side—such as exclusionary nationalism and political authoritarianism—it is important to investigate whether participants are willing to critically engage their personal political histories. What do they now say about their roles in this episode? In order to provide answers to this question, six focus groups with a total of 34 participants were organized in the town of Novi Sad, the location of one of the best-known rallies of the antibureaucratic revolution, the so-called yogurt revolution. Most people see their involvement in a rather negative way and regret taking part. However, two blind spots also appear that lessen their sense of personal responsibility: conspiracy theories and notions of urban superiority. The former shifts blame onto secret forces and the latter onto nonurban outsiders. Overall, the long-term legacies of the antibureaucratic revolution are negative: they are associated with cynicism and apathy.
Revolutionary Origins of Political Regimes and Trajectories of Popular Mobilization in the Late Communist Period
Authors: Vladisavljević Nebojša
Published: September 2019

Popular protest, which repeatedly occurred in Communist regimes, turned into massive mobilizational waves in the late Communist period. Why did some protests result in state cooptation and particularist nationalism (Yugoslavia and the Soviet Union), and others in state-society polarization (Poland) and protest containment (China), when these states shared important historical, political, and institutional legacies? Political regimes with origins in indigenous popularly-based revolutionary movements are more resilient to popular protests and other major crises than other authoritarian regimes. Protracted ideological armed struggle largely overlaps with broader patriotic causes, such as liberation wars or struggles against foreign intervention. The revolutionary regimes thus acquire patriotic credentials, while boundaries between partisan and patriotic identities become blurred, which strengthens their elite unity and popular base. Popular protests thus facilitate a complex political game of old and new actors that may result in regime survival or transformation. In other regimes, popular unrest tends to produce state-society polarization and, ultimately, regime delegitimation and breakdown. Popular contention in complex multinational institutional settings, if there is no major external threat, highlights old and triggers new conflicts along these structural and institutional divides and, where dual political identities prevail, facilitates identity shifts in particularist direction.
Reducing soil erosion in smallholder farming systems in east Africa through the introduction of different crop types
Authors: Muoni Tarirai , Koomson Eric , Öborn Ingrid , Marohn Carsten , Watson Christine A. , Bergkvist Göran , Barnes Andrew , Cadisch Georg , Duncan Alan
Published: September 2019

On low-input smallholder farms of Kenyan upland landscapes, erosion of nutrient-rich topsoil strongly affects crop yields. Where maize (Zea mays) is intercropped on erosion-prone slopes, intercropping can potentially reduce soil erosion. The objective of this research was to quantify the contribution of crops and crop mixtures of different growth habits to erosion control and their influence on above-ground biomass and earthworm abundance as indicators of soil function in smallholder farming systems under a bimodal rainfall pattern in Western Kenya. The experiment involved five treatments, namely maize (Z. mays)/common bean (Phaseolus vulgaris) intercrop (maize intercrop), maize/common bean intercrop plus Calliandra (Calliandra calothyrsus) hedgerows and Calliandra mulch (Calliandra), sole Lablab (Lablab purpureus), sole Mucuna (Mucuna pruriens) and groundnut (Arachis hypogaea) intercropped with maize (during the short rains). The experiment was conducted over three consecutive cropping seasons and the cropping system had significant effects on soil loss, runoff, water infiltration, earthworm abundance and above-ground biomass and crop grain yield. The Calliandra treatment had the lowest runoff (11.6–17.2 mm ha−1) and soil erosion (31–446 kg ha−1 per season) in all the seasons, followed by the Mucuna treatment. Lablab was affected by disease and showed the highest soil erosion in the last two seasons. Infiltration was highest in Calliandra treatment, and earthworm abundance was higher under Mucuna and Calliandra treatments (229 and 165 earthworms per square metre, respectively) than under other crops. Our results suggest that including sole crops of herbaceous species such as Mucuna, or tree hedgerows with mixtures of maize and grain legumes has the potential to reduce runoff and soil erosion in smallholder farming. Additionally, these species provide a suitable habitat for earthworms which stabilise soil structure and macropores and thus potentially increase infiltration, further reducing soil erosion.
The Gold Pool (1961–1968) and the Fall of the Bretton Woods System: Lessons for Central Bank Cooperation
Authors: Bordo Michael , Monnet Eric , Naef Alain
Published: September 2019

The Gold Pool was probably the most ambitious case of central bank cooperation in history. Major central banks pooled interventions to stabilize the dollar price of gold. Why did it collapse? From at least 1964, the fate of the Pool was, in fact, tied to sterling, the first line of defense for the dollar. Sterling’s devaluation in November 1967 eventually spurred speculation and unbearable losses for the Pool. Inflationary U.S. policies were weakening confidence in the dollar. The demise of the Pool provides a striking example of contagion between reserve currencies and the limits of central bank cooperation.
Anchoring on Historical High Prices and Seasoned Equity Offerings
Authors: Hovakimian Armen , Hu Huajing
Published: September 2019

We document that firms’ financing decisions are affected by historical high prices. The ratio of the monthly high price to the 12-month historical high price positively affects the probability of a seasoned equity offering (SEO). Furthermore, the postannouncement market reaction is muted and the offering discount is smaller if the preannouncement stock price is high relative to its historical high price. The results suggest that historical high price reference points may help managers rationally time SEOs to take advantage of market reception and minimize issuance costs.
Corruption and Corporate Innovation
Authors: Ellis Jesse , Smith Jared , White Roger
Published: September 2019

We examine whether political corruption impedes innovation. Using a comprehensive sample of U.S. firms, we find that corruption has a substantial, negative relation with the quantity and quality of innovation. These results are robust to using various fixed effects, proxies for corruption and innovation, and subsamples. To establish causality, we employ 2 instruments for corruption: local ethnic diversity and the corruption of the state a firm’s founder grew up in. Corruption appears to reduce innovation output both on average and for the most innovative firms. Overall, this evidence is consistent with the notion that corruption reduces social welfare by impeding innovation.
The Revolutionary City: Socialist Urbanisation and Nuclear Modernity in Cienfuegos, Cuba
Authors: Cederlöf Gustav
Published: September 2019

During the Cold War, Havana symbolised the struggle for national liberation in Latin America. Yet in few other places on the island of Cuba did the Revolution's visions of development materialise as they did in the southern city of Cienfuegos. This article examines why two half-finished nuclear reactors and a decaying ‘nuclear city’ still remain in Cienfuegos. Through a comprehensive spatial and infrastructural transformation of Cuba, the revolutionary government sought to remedy the evils of dependency and unequal exchange. Cienfuegos, and its shifting place in the Cold War political economy, demonstrates how a radical critique of urbanisation merged with the spatiality of centralised energy infrastructure in the pursuit of ultimately-failed nuclear modernity. The history of Cienfuegos draws the academic gaze away from Latin America's major cities to broaden the ‘geographies of theory’ in urban, energy and Latin American studies.
Between life, security and rights: Framing the interdiction of ‘boat migrants’ in the Central Mediterranean and Australia
Authors: Moreno-Lax Violeta , Ghezelbash Daniel , Klein Natalie
Published: September 2019

This article sets out two case studies to examine the evolving reality of ‘boat migration’ and the intersecting legal frameworks at play. Our analysis takes a systemic integration approach to reflect on the complex dynamics underpinning responses to the phenomenon in Australia and the Central Mediterranean. The regime that governments purport to act under in any given instance reflects the way they choose to frame incidents and possibly exploit legal gaps in, or contested interpretations of, the relevant rules. The ‘closed ports’ strategy adopted by Italy and Malta against the MV Lifeline and the detention-at-sea policy pursued by Australia are investigated from the competing perspectives of what we call the ‘security lens’ and the ‘humanitarian lens’ to demonstrate how a good faith interpretation of the applicable (if apparently conflicting and overlapping) norms can (and should) be mobilized to save lives, and how that goal is unduly undercut when security concerns trump humanitarian interests.
Addiction and Voluntariness: Five “Challenges” to Address in Moving the Discussion Forward
Authors: RACINE ERIC , BARNED CLAUDIA
Published: September 2019

The question as to whether people with an addiction have control (and to what extent) over their addiction, and voluntarily decide to use substances is an ongoing source of controversy in the context of research on addiction, health policy and clinical practice. We describe and discuss a set of five challenges for further research into voluntariness (definition[s], measurement and study tools, first person perspectives, contextual understandings, and connections to broader frameworks) based on our own research experiences and those of others.
Moving Beyond ‘Therapy’ and ‘Enhancement’ in the Ethics of Gene Editing
Authors: CWIK BRYAN
Published: September 2019

Since the advent of recombinant DNA technology, expectations (and trepidations) about the potential for altering genes and controlling our biology at the fundamental level have been sky high. These expectations have gone largely unfulfilled. But though the dream (or nightmare) of being able to control our biology is still far off, gene editing research has made enormous strides toward potential clinical use. This paper argues that when it comes to determining permissible uses of gene editing in one important medical context—germline intervention in reproductive medicine—issues about enhancement and eugenics are, for the foreseeable future, a red herring. Current translational goals for gene editing research involve a different kind of editing than would be required to achieve manipulation of complex traits such as intelligence, and there are more pressing (and unresolved) questions that need attention if clinical use of gene editing in reproductive medicine ever becomes a possibility.
The limits of plain legal language: understanding the comprehensible style in law
Authors: Ződi Zsolt
Published: September 2019

The comprehensible style of legal texts seems to be a predominantly linguistic problem. This is how the plain-legal-language movements present it. But, while plain-language statutes have been on the agenda for decades in every civilised country, laws still become more and more complicated. The paper attempts to explain this controversy. First, it argues that comprehensibility has more aspects beyond the linguistic or stylistic one. Sometimes it is the linguistically simplest texts that raise the most serious comprehensibility problems. The paper refers to two pieces of corpus linguistic research that provide evidence that vocabulary and grammar in themselves do not explain the incomprehensibility of the legal texts. Second, for a more subtle handling of the comprehensibility problem, the paper offers a framework of three typical pragmatic situations – the processual, the problem-solving and the compliance settings – where comprehensibility problems arise in different ways. The conclusion of the paper is that, contrary to the usual explanation that the main reason for incomprehensibility is that, in law, clarity and accuracy can be only employed at each other's expense, it is rather the systemic and interpretive character of law and the growing importance of technical rules that hinder the understanding of legal texts.
Towards a semiotic theory of style in law: a Peircean approach
Authors: Bor Bettina , Könczöl Miklós
Published: September 2019

This paper discusses the promises and limits of a Peircean semiotic approach to the concept of style in law. It does so in two steps: first (1) by identifying the place of style within the structure of law as a system of signs, then (2) by conceptualising the link between law and style in the thought of C.S. Peirce and highlighting some of the insights from a Peircean take on legal semiotics that may contribute to our understanding of the role of style in making meaning in law. It is argued that, for a Peircean analysis of law, three levels can be distinguished, from the ‘surface structure’ down to the ‘deep structure’. It is at the middle level (that of the ‘basic structure’) that a semiotic approach can yield coherent insights in terms of style, by examining the symbols and metaphors that make for the expressibility of ‘habits’, namely experience-based patterns of action and interpretation.
TwinsUK: The UK Adult Twin Registry Update
Authors: Verdi Serena , Abbasian Golboo , Bowyer Ruth C. E. , Lachance Genevieve , Yarand Darioush , Christofidou Paraskevi , Mangino Massimo , Menni Cristina , Bell Jordana T. , Falchi Mario , Small Kerrin S. , Williams Frances M. K. , Hammond Christopher J. , Hart Deborah J. , Spector Timothy D. , Steves Claire J.
Published: September 2019

TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition, over 1800 parents and siblings of twins are registered volunteers. During the last 27 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioral, dietary and socioeconomic cohort characterization; it provides a multidisciplinary platform for the study of complex disease during the adult life course, including the process of healthy aging. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genomewide scans of single-nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community — interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK.
Ceres: Evolution of the Asteroid Belt’s Icy Giant
Authors: Hauck II Steven , Sizemore Hanna
Published: September 2019

A new special collection in JGR: Planets explores how ice has played a key role in the development of the landscape on the surface of Ceres.
Estimating the Health‐Related Costs of 10 Climate‐Sensitive U.S. Events During 2012
Authors: Limaye Vijay S. , Max Wendy , Constible Juanita , Knowlton Kim
Published: September 2019

Climate change threatens human health, but there remains a lack of evidence on the economic toll of climate‐sensitive public health impacts. We characterize human mortality and morbidity costs associated with 10 climate‐sensitive case study events spanning 11 US states in 2012: wildfires in Colorado and Washington, ozone air pollution in Nevada, extreme heat in Wisconsin, infectious disease outbreaks of tick‐borne Lyme disease in Michigan and mosquito‐borne West Nile virus in Texas, extreme weather in Ohio, impacts of Hurricane Sandy in New Jersey and New York, allergenic oak pollen in North Carolina, and harmful algal blooms on the Florida coast. Applying a consistent economic valuation approach to published studies and state estimates, we estimate total health‐related costs from 917 deaths, 20,568 hospitalizations, and 17,857 emergency department visits of $10.0 billion in 2018 dollars, with a sensitivity range of $2.7–24.6 billion. Our estimates indicate that the financial burden of deaths, hospitalizations, emergency department visits, and associated medical care is a key dimension of the overall economic impact of climate‐sensitive events. We found that mortality costs (i.e., the value of a statistical life) of $8.4 billion exceeded morbidity costs and lost wages ($1.6 billion combined). By better characterizing health damages in economic terms, this work helps to shed light on the burden climate‐sensitive events already place on U.S. public health each year. In doing so, we provide a conceptual framework for broader estimation of climate‐sensitive health‐related costs. The high health‐related costs associated with climate‐sensitive events highlight the importance of actions to mitigate climate change and adapt to its unavoidable impacts.
Role of the dorsal periaqueductal gray in posttraumatic stress disorder: mediation by dopamine and neurokinin
Authors: Brandão M. L. , Lovick T. A.
Published: September 2019

In susceptible individuals, exposure to intensely traumatic life events can lead to the development of posttraumatic stress disorder (PTSD), including long-term dysregulation of the contextual processing of aversive stimuli, the overgeneralization of learned fear, and impairments in the ability to learn or respond to safety signals. The neuropathophysiological changes that underlie PTSD remain incompletely understood. Attention has focused on forebrain structures associated with fear processing. Here we consider evidence from human and animal studies that long-lasting changes in functional connectivity between the midbrain periaqueductal gray (dPAG) and amygdala may be one of the precipitating events that contribute to PTSD. Long-lasting neuroplastic changes in the dPAG can persist after a single aversive stimulation and are pharmacologically labile. The early stage (at least up to 24 h post-stimulation) involves neurokinin-1 receptor-mediated events in the PAG and amygdala and is also regulated by dopamine, both of which are mainly involved in transferring ascending aversive information from the dPAG to higher brain structures, mainly the amygdala. Changes in the functional connectivity within the dPAG-amygdala circuit have been reported in PTSD patients. We suggest that further investigations of plasticity and pharmacology of the PAG-amygdala network provide a promising target for understanding pathophysiological circuitry that underlies PTSD in humans and that dopaminergic and neurokininergic drugs may have a potential for the treatment of psychiatric disorders that are associated with a dysfunctional dPAG.