bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the Nature‒Nurture Debate
Authors: Turkheimer Eric
Published: November 2024

There are arguably few areas of science more fiercely contested than the question of what makes us who we are. Are we products of our environments or our genes? Is nature the governing force behind our behaviour or is it nurture? While it is now widely agreed that it is a mixture of both, discussions continue as to which is the dominant influence. This unique volume presents a clear explanation of heritability, the ongoing nature versus nurture debate and the evidence that is currently available. Starting at the beginning of the modern nature-nurture debate, with Darwin and Galton, this book describes how evolution posed a challenge to humanity by demonstrating that humans are animals, and how modern social science was necessitated when humans became an object of natural science. It clearly sets out the most common misconceptions such as the idea that heritability means that a trait is 'genetic' or that it is a justification for eugenics.
Sex Differences in Moderate-to-Severe Traumatic Brain Injury Randomized Controlled Trials
Authors: Flores-Sandoval Cecilia , MacKenzie Heather M. , Bateman Emma A. , Sequeira Keith , Bayley Mark , Teasell Robert
Published: November 2024

Background:

Understanding sex differences among persons with moderate-to-severe traumatic brain injury (TBI) is critical to addressing the unique needs of both males and females from acute care through to rehabilitation. Epidemiological studies suggest that 7 of every 10 persons with moderate-to-severe TBI are male, with females representing about 30%–33%.

Objective:

To examine the proportion of female and male individuals included in randomized controlled trials (RCTs) of interventions for moderate-to-severe TBI.

Methods:

A systematic review was conducted in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines up to and including December 2022 using MEDLINE, PubMed, Scopus, CINAHL, EMBASE and PsycINFO databases. Studies were included if they met the following criteria: (1) human participants with a mean age ≥18 years, (2) ≥50% of the sample had moderate-to-severe TBI and (3) the study design was a RCT. Data extracted included author, year, country, sample size, number of female/male participants and time post-injury.

Results:

595 RCTs met the criteria for inclusion, published between 1978 and 2022, totaling 86,662 participants. The average proportion of female participants was 23.14%, and the percentage increased a small but significant amount over time. There was a significantly lower percentage of female participants in RCTs initiated in the acute phase (≤ 1 month) when compared with RCTs conducted in the chronic phase (≥ 6 months) post-injury (p < 0.001).

Conclusions:

Female participants are underrepresented in RCTs of moderate-to-severe TBI. Addressing this underrepresentation is critical to establish effective treatments for all persons with TBI.
Updated Canadian Headache Society Migraine Prevention Guideline with Systematic Review and Meta-analysis
Authors: Medrea Ioana , Cooper Paul , Langman Marissa , Sandoe Claire H. , Amoozegar Farnaz , Hussain Wasif M. , Bradi Ana C. , Dawe Jessica , Guay Meagan , Perreault Francois , Reid Stuart , Todd Candice , Skidmore Becky , Christie Suzanne N.
Published: November 2024

Objective:

We have updated the migraine prevention guideline of the Canadian Headache Society from 2012, as there are new therapies available, and additionally, we have provided guidelines for the prevention of chronic migraine, which was not addressed in the previous iteration.

Methods:

We undertook a systematic review to identify new studies since the last guideline. For studies identified, we performed data extraction and subsequent meta-analyses where possible. We composed a summary of the evidence found and undertook a modified Delphi recommendation process. We provide recommendations for treatments identified and additionally expert guidance on the use of the treatments available in important clinical situations.

Results:

We identified 61 studies that were included in this evidence update and identified 16 therapies we focused on. The anti-calcitonin gene-related peptide (CGRP) agents were approved by Health Canada between 2018 and 2024 and provide additional options for episodic and chronic migraine prevention. We also summarize evidence for the use of propranolol, topiramate and onabotulinumtoxinA in addition to anti-CGRP agents as treatments for chronic migraine. We have downgraded topiramate to a weak recommendation for use and gabapentin to a weak recommendation against its use in episodic migraine. We have weakly recommended the use of memantine, levetiracetam, enalapril and melatonin in episodic migraine.

Conclusion:

Based on the evidence synthesis, we provide updated recommendations for the prevention of episodic and chronic migraine utilizing treatments available in Canada. We additionally provided expert guidance on their use in clinical situations.
Maternal labor supply and children's emotional well-being
Authors: Jofre-Bonet M. , Rossello-Roig M. , Serra-Sastre V.
Published: November 2024

This study explores the relationship between maternal working hours and a child's emotional well-being using data from the UK Millennium Cohort Study. Child well-being is assessed through self-reported happiness and a well-being index that includes concerns, temperament, bullying, and behaviour. Results show a positive association between maternal employment and child well-being, supported by factor analysis combining child, mother, and teacher reports. The association remains consistent across income levels and is unaffected by commuting time or cohabitation status. These findings highlight the importance of maternal employment and contextual factors in shaping child well-being.
Semistable degenerations of Calabi–Yau manifolds and mirror P=W conjectures
Authors: Lee Sukjoo
Published: November 2024

Mirror symmetry for a semistable degeneration of a Calabi–Yau manifold was first investigated by Doran–Harder–Thompson when the degenerate fiber is a union of two quasi-Fano manifolds. They proposed a topological construction of a mirror Calabi–Yau by gluing of two Landau–Ginzburg models that are mirror to those Fano manifolds. We extend this construction to a general type semistable degeneration where the dual boundary complex of the degenerate fiber is the standard N-simplex. Since each component in the degenerate fiber comes with the simple normal crossing anticanonical divisor, one needs the notion of a hybrid Landau–Ginzburg model – a multipotential analogue of classical Landau–Ginzburg models. We show that these hybrid Landau–Ginzburg models can be glued to be a topological mirror candidate for the nearby Calabi–Yau, which also exhibits the structure of a Calabi–Yau fibration over

$\mathbb P^N$

. Furthermore, it is predicted that the perverse Leray filtration associated to this fibration is mirror to the monodromy weight filtration on the degeneration side [12]. We explain how this can be deduced from the original mirror P=W conjecture [18].
Amid magic and menace: psychiatrists’ attitudes to psilocybin therapy
Authors: Gribben Andrew , Burke Tara , Harrington Colm , Husein Amanda , Murnane Kevin S. , Hendricks Peter. S. , Tobin Katy , Ivers Jo-Hanna , Thuery Guillaume , Harkin Andrew , Kelly John R.
Published: November 2024

Objectives:

Understanding variations in knowledge and attitudes of psychiatrists to psilocybin therapy is important for the collective discourse about the potential impact on clinical practice and public health in Ireland.

Methods:

A 28-item questionnaire was designed based on previous studies and distributed to psychiatrists in Ireland via online mailing lists and at in-person academic events.

Results:

151 psychiatrists completed the questionnaire (73.3% were under 40 years of age, 76.0% were trainees, and 49.0% were female). In the total sample, 81.5% agreed that psilocybin therapy shows promise in the treatment of psychiatric disorders and 86.8% supported funding research, 86.8% would be willing to refer a patient if it was licensed and indicated, and 78.1% would consider the treatment for themselves, if indicated. Conversely, 6.6% agreed that psilocybin therapy was unsafe even under medical supervision, and 21.9% thought it was potentially addictive. 15.9% of the total sample reported at least one concern including, lack of robust evidence, long-term effectiveness, superiority to current interventions, potential harmful effects, cost and accessibility, and impartiality. Less than half of respondents felt knowledgeable (40.0%) and 9.9% felt adequately prepared to participate in psilocybin therapy. Consultant psychiatrists trended towards less optimism for a potential role in bipolar depression and emotionally unstable personality disorder compared to trainee psychiatrists.

Conclusion:

Overall psychiatrists in Ireland held positive attitudes towards psilocybin therapy. However, there was a lack of knowledge evident. Addressing the knowledge gap and aligning with the best available evidence will be key if psychedelic therapy is to prevail in a clinical setting.
Impact of axial strain on linear, transitional and self-similar turbulent mixing layers
Authors: Pascoe B. , Groom M. , Youngs D.L. , Thornber B.
Published: November 2024

In convergent geometry, the effect of convergence and compression on the Rayleigh–Taylor instability (RTI) and Richtmyer–Meshkov instability (RMI) modifies the growth rate and behaviour of the instabilities. In order to better understand how compression/expansion caused by axial strain rates (i.e. strain rates normal to the interface) change the instability dynamics, axial strain rates are applied to RMI in planar geometry, isolated from the effects of convergence. Potential flow theory for the linear regime shows the growth rate of the instability is modified to include the background velocity difference of the instability's width. Resolved two-dimensional simulations of single-mode RMI showed the potential flow model is accurate whilst the amplitude is small compared with the wavelength. The application of strain rate to an RMI-induced mixing layer was investigated using three-dimensional implicit large eddy simulations (ILES) of the quarter-scale

$\theta$

-group case by Thornber et al. (Phys. Fluids, vol. 29, 2017, 105107). Whilst the background strain rate contributed to the mixing layer's growth, it was to a smaller extent than expected. The shear production of axial turbulent kinetic energy from the strain rate modified the rate of bulk entrainment, affecting the mixing layer's growth and mixedness, such that the strained simulations no longer attained the same self-similar state. The capability of the buoyancy-drag model by Youngs & Thornber (Physica D, vol. 410, 2020, 132517) to predict the mixing layer width was investigated, using a model calibrated to the unstrained case. New terms were introduced into the buoyancy-drag model, which correspond to the shear production of turbulent kinetic energy.
What can we learn about mental health from 10,933 patient lived experiences using a novel quantitative-qualitative network analysis?
Authors: Ghosh Chandril Chandan , McVicar Duncan , Davidson Gavin , Shannon Ciaran , Armour Cherie
Published: November 2024

Objective: The study aims to build a comprehensive network structure of psychopathology based on patient narratives by combining the merits of both qualitative and quantitative research methodologies. Research methods: The study web-scraped data from 10,933 people who disclosed a prior DSM/ICD11 diagnosed mental illness when discussing their lived experiences of mental ill health. The study then used Python 3 and its associated libraries to run network analyses and generate a network graph. Key findings: The results of the study revealed 672 unique experiences or symptoms that generated 30023 links or connections. The study also identified that of all 672 reported experiences/symptoms, five were deemed the most influential; “anxiety,” “fear,” “auditory hallucinations,” “sadness,” and “depressed mood and loss of interest.” Additionally, the study uncovered some unusual connections between the reported experiences/symptoms. Discussion and recommendations: The study demonstrates that applying a quantitative analytical framework to qualitative data at scale is a useful approach for understanding the nuances of psychopathological experiences that may be missed in studies relying solely on either a qualitative or a quantitative survey-based approach. The study discusses the clinical implications of its results and makes recommendations for potential future directions.
Weaponized Virality: The Harris Campaign’s TikTok Dramaturgy
Authors: Rosvally Danielle
Published: November 2024

Kamala Harris is the first American Presidential Candidate to understand TikTok. Both her personal feed and campaign feed demonstrate this understanding. This essay will unpack what it means to create TikTok native content, and how Harris is doing so on TikTok.
‘The Most Beautiful Sound’: The Queer Nexus of Listening and Voice in the Early Modern Italian Convent
Authors: JOHNSON LINDSAY MAUREEN
Published: November 2024

The convent in Early Modern Italy functioned as a uniquely queer space, denying women heteronormative lives while producing homosocial, virginal communities. As nuns wove together the dual acts of listening and vocalizing, they built queer sonic environments that were the site of massive power struggles between male church officials, the bodies of women religious, and the wealthy families of Italy. Connecting voice studies, feminist and queer musicology, sound studies, and nun studies to explore new ways of approaching convent musicking, the author examines Lucrezia Orsina Vizzana’s ‘O magnum mysterium’ to illuminate the possibilities of women’s agency and queerly inflected performance.
Recommended or high daily intakes of plant stanol esters do not affect ex vivo T-cell derived cytokine production in immunologically healthy volunteers
Authors: van Brakel Lieve , Brüll Florence , Lasfar Anissa , Zwaan Willem , de Jong Arienne , Mensink Ronald P. , Plat Jogchum
Published: November 2024

A well-functioning immune system requires balanced immune responses. In vitro studies have shown that plant stanols contribute to restoring the T-helper (Th)1/Th2 ratio when it is imbalanced. However, effects of plant stanols on healthy immune responses are unknown. Therefore, we studied effects of recommended (2·5 g/d) or high (9·0 g/d) plant stanol intakes on the Th1/Th2 cytokine balance in immunologically healthy subjects. In two RCTs, peripheral blood mononuclear cells (PBMCs) were isolated, cultured, and stimulated with 5 µg/ml Phytohemagglutinin-M to study ex vivo cytokine production. In the first study, twenty participants consumed margarines (2·5 g/d plant stanols) or control for three weeks. In the second study, nineteen participants consumed margarines and yogurts (9·0 g/d plant stanols) or control for four weeks. T-cell cytokine concentrations were measured in culture medium and in study 2 a standardized Th1/Th2 index was calculated. Serum lipids and non-cholesterol sterols were also measured. Compliance was confirmed by significant increases in serum total cholesterol (TC)-standardized sitostanol and campestanol levels in both studies. Changes in ex vivo cytokine production and Th1/Th2 index did not differ between intervention and control groups. In the first study, no statistically significant changes were observed in lipid and lipoprotein concentrations. In the second study, LDL cholesterol significantly decreased compared to control (–0·77 (–1·11, –0·42) mmol/l; P < 0·001). Recommended (2·5 g/d) or high (9·0 g/d) intakes of plant stanols did not alter PBMC ex vivo cytokine production in immunologically healthy subjects. This suggests that plant stanols might only affect immune function when Th1/Th2 immune responses are imbalanced.
Nutritional quality of proteins from two beef co-products as determined in the growing pig
Authors: Le Foll Rozenn , Nau Françoise , Le Gouar Yann , Henry Gwénaële , Chevalier Séverine , Leduc Arlette , Hamon Pascaline , Guérin-Dubiard Catherine , Lambert Xavier , Lechevalier Valérie , Deglaire Amélie
Published: November 2024

The increasing demand for food and especially proteins leads to the search for alternative protein sources. Meat co-products, which are available but little used in human food, provide a potential solution to this challenge. The present study aimed to evaluate the nutritional quality of two beef protein ingredients (greasy greaves recovered proteins (GGRP) and water recovered proteins (WRP)), both co-products of the fat rendering process. Their true ileal digestibility (TID), digestible indispensable amino acid score (DIAAS) and kinetics of plasma amino acids (AA) were measured in ten growing pigs, each fed the two co-products and a protein-free diet. Titanium dioxide was used as an indigestible marker. Digesta samples were collected for 9 h after meal ingestion, and blood samples were collected at ten time points during the same period. Total nitrogen (N) and AA contents were determined. Data were statistically analysed using linear mixed models. The TID of total N was not different between WRP and GGRP (81–84 %, P > 0·05). The first-limiting AA was Trp for both ingredients, with a DIAAS much higher for GGRP than for WRP (74 and 10 % for adults, respectively; P < 0·001). Postprandial plasma AA concentration peaked earlier for WRP (3 h) than for GGRP (5 h). Plasma concentrations of total and essential AA were higher (P < 0·001) with GGRP diet than WRP diet. Overall, GGRP has a nutritional quality suitable to meet the needs of adults for AA, while WRP needs to be supplemented with other protein sources to fulfil the dietary requirements.
School connectedness as a protective factor between childhood adversity and adolescent mental health outcomes
Authors: Diggs Devin , Deniz Emre , Toseeb Umar
Published: November 2024

School connectedness may offset mental health risks associated with childhood adversity. The present study examined the potential protective effects of school connectedness against childhood adversity when predicting adolescent mental health outcomes in 9,964 individuals (51% female, 81% white) from the Millennium Cohort Study. Structural equation models were fitted to examine the longitudinal relationships between childhood adversity, school connectedness, and adolescent mental health. Childhood adversity was a risk factor, predicting greater internalizing and externalizing problems and lower levels of positive mental health. School connectedness was a promotive factor as it predicted fewer mental health problems and greater positive mental health. Furthermore, school connectedness at age 11 was protective against childhood adversity when predicting internalizing and externalizing problems at age 14. That is, students with a history of adversity who felt more connected to school were less likely to exhibit internalizing and externalizing symptoms than those who felt less connected to school. Only school connectedness at age 11 was protective against childhood adversity, indicating that feeling connected to school at younger ages may disrupt processes linking childhood adversity to adolescent mental health. Schools should foster students’ feelings of connectedness to protect vulnerable individuals and benefit all pupils’ mental health.
Behavioral activation program for reducing depressive symptoms among the bereaved of cancer patients: A feasibility and preliminary effectiveness study in Japan
Authors: Asai Mariko , Ogawa Yuko , Hirayama Takatoshi , Sukigara Nozomi , Yoshikawa Eisho , Furutani Sawako , Fujimori Maiko , Akechi Tatsuo , Suzuki Shinichi
Published: November 2024

Objectives

This study aimed to examine the feasibility and preliminary effectiveness of a behavioral activation (BA) program for the bereaved of cancer patients toward reducing depressive symptoms.

Methods

The BA program for the bereaved was a partially modified version for cancer patients. This program encompassed a preinterview and seven 50-minute sessions every 1–2 weeks, using worksheets, with homework assignments each day. To examine feasibility, the completion rates of intervention and 3 months of follow-up were examined. To examine the preliminary effectiveness, psychological symptoms were assessed with the Patient Health Questionnaire (PHQ-9; primary outcome) and Beck Depression Inventory-II (BDI-II) for depression and the Generalized Anxiety Disorder-7 (GAD-7) for anxiety. These were evaluated 3 times: before, immediately after, and 3-month post-intervention. Non-parametric tests were used for comparison of scores at 3 time points and calculation of effect size.

Results

Of the 42 bereaved who were contacted, 21 were eligible and 20 were participated, while 19 and 18 were in the completed intervention and completed 3-month post-intervention categories (intervention completion rate was 95% and follow-up completion rate was 90%). PHQ-9, BDI-II, and GAD-7 showed significant reductions immediately and 3 months after the intervention compared to pre-intervention, and the effect sizes were all large after 3 months, although they were less than immediately after (PHQ-9: 0.89, 0.71; BDI-II: 0.88, 0.67; GAD-7: 0.57, 0.53).

Significance of results

This study indicated that the BA program for the bereaved of cancer patients was feasible and effective vis-à-vis reducing depressive symptoms.
The role of populist NGOs in building a populist democracy in Hungary
Authors: Gárdos-Orosz Fruzsina , Szente Zoltán
Published: November 2024

What are the legal and political criteria that distinguish between ‘correct’ and ‘unacceptable’ legal mobilisation? How does populism facilitate legal mobilisation? The questions of the workshop organizers led us back in Hungary to the democratic transition from socialism to liberal democracy in 1989, when legal mobilisation for the rule of law, democracy and human rights was led first and primarily by non-state actors (National Round Table). Participants of the democratic transition prepared the complete revision of the 1949 Constitution, which was an emblematic element in addition to the many legislative drafts of the transitory nature of the creation of the new system. In 2010, after the successful political mobilisation, the populist party coalition (lead by Viktor Orban) gained a two-thirds constitution-making majority in Parliament (in the absence of two opposition parties), and the Parliament adopted the new Fundamental Law (new constitution). This was also an emblematic element of the new legal mobilisation conducted by the two-thirds populist Government majority. This article will describe how populism – through the instrumentalisation of the law (disregarding the inherent values in/of law based on value choice) and the destruction of institutional checks and balances – facilitated new legal mobilisation. Based on this experience of the outcome of the equally strong and effective legal mobilisation in Hungary of the liberal and the illiberal (democratic and autocratic, respectively) transitions, in this article we aim to make valid theoretical propositions on how to assess ‘correct’ and ‘incorrect’ legal mobilisation and what influences the relevance of non-state actors in populism.
Examining the Interconnectedness of State High Court Twitter
Authors: Curry Todd A. , Fix Michael P. , Romano Michael K.
Published: November 2024

Judges are not the first political officials that come to mind when one considers the role of social media in modern politics. Following in the wake of some prominent judicial personalities adopting Twitter, however, a growing number of state high court judges have adopted and established more public personas on the platform. Judges use Twitter in substantively different ways than traditional elected officials (Curry and Fix 2019); however, little is understood about how the use of such social media platforms affects broader judicial networks. Recognizing that judges, like typical social media users, may aspire to expand their networks to build and appeal to broader audiences, we contend that active participation in judicial Twitterverse could yield personal and professional advantages. Here, we address a currently unexplored question: To what extent have judges formed a distinctive “judicial network,” on Twitter, and what discernible patterns present in these networks? Leveraging the unique structure of social media, we collect comprehensive network data on judging using Twitter and analyze what institutional and social factors impact greater power within the judicial network. We find that early adoption, electoral concerns, and connective links between judges all impact the strength of the judicial network, highlighting the complex motivations driving judicial Twitter engagement, and the significance of network building in judges’ social media strategies and its potential impact on career advancement.
Placental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations
Authors: Dave Eesha , Ozan Bahtiyar Mert , Campbell William , Morotti Raffaella , Kohari Katherine
Published: November 2024

Placental vascular anastomoses are traditionally thought to exist exclusively in monochorionic pregnancies. However, they have been reported in dichorionic twin pregnancies as well. In turn, twin to twin transfusion syndrome (TTTS) and twin anemia polycythemia sequence (TAPS) have also been noted to impact some of these gestations. Through discussion of one such case at our institution along with a review of the available literature, we review the proposed pathophysiology of placental vascular anastamoses in dichorionic twin gestations, and aim to raise awareness of the possibility of associated pathologies in dichorionic gestations. This is an emerging area of literature that will require future study to guide prenatal surveillance and mitigate morbidity.
Tracing a Mantle Component in Both Paleo and Modern Fluids Along Seismogenic Faults of Southern Italy
Authors: Zummo Filippo , Agosta Fabrizio , Álvarez‐Valero Antonio M. , Billi Andrea , Buttitta Dario , Caracausi Antonio , Carnevale Gabriele , Marchesini Barbara , Paternoster Michele
Published: November 2024

Aiming at understanding the source of the fluids that mineralizing within seismically active fault zones, we investigate the noble gas isotopes (i.e., helium (He), neon (Ne), and argon (Ar)) in the fluid inclusions (FIs) trapped in the calcite veins sampled along high‐angle fault zones of the Contursi hydrothermal basin, southern Italy. The latter basin lies in close vicinity of the MW = 6.9, 1980 Irpinia earthquake and exposes numerous fault scarps dissecting Mesozoic shallow‐water carbonates. The analyses of noble gases (He, Ne, Ar) are conducted to identify the origin of the volatiles circulating along the faults at the time of calcite precipitation. Then, outcomes of this discussions are compared with currently outgassing of deep‐sourced CO2 coupled to mantle‐derived He in that area, whose output is larger than those from some volcanic areas worldwide. The results indicate that He in FIs is dominated by a crustal radiogenic component (4He), and by an up to 20% of a mantle‐derived component (3He), with a highest isotopic signature of 1.38 Ra. This value is consistent with the highest percentage of mantle‐derived He associated to high‐flux CO2 gas emission in the investigated area (1.41 Ra). We propose that the variability of the He isotopic signature measured in primary FIs can result from early trapping of fluid inclusions or post trapping processes and seismic activity that modify the pristine He isotopic signature (i.e., derived from the crust and/or mantle) in groundwater along the faults during periods of background seismicity. Such investigations are fundamental to understand fluid migration in fault systems and the role of fluids in processes of earthquake nucleation.
Air‐Sea Turbulent Heat Flux Affects Oceanic Lateral Eddy Heat Transport
Authors: Wu Weiguang , Mahadevan Amala
Published: November 2024

Sea surface temperature anomaly (SSTA) of ocean eddies induces an anomalous air‐sea turbulent heat flux that acts to dampen SSTA. A two‐dimensional SSTA model explores the effect of air‐sea turbulent heat flux, parameterized as SSTA damping, in shaping eddy SSTA patterns. Increased SSTA damping transitions the SSTA pattern from a monopole to dipole, indicating the balance between eddy stirring of the background SST gradient and SSTA damping. The SSTA dipole pattern increases the correlation of eddy velocity and SSTA, but SSTA damping weakens the SSTA, resulting in an optimal damping rate maximizing lateral eddy surface heat transport. Globally, the SSTA damping rate increases toward the equator. In mid‐latitude and high‐latitude regions (e.g., the Kuroshio, the Gulf Stream, and the Southern Ocean), eddy SSTAs are monopoles, while the tropics and subtropics exhibit dipole SSTA patterns due to higher damping rates, facilitating greater lateral eddy heat transport when the SSTA is large.
Mercury's Crustal Porosity as Constrained by the Planet's Bombardment History
Authors: Broquet A. , Rolser F. , Plesa A. C. , Breuer D. , Hussmann H.
Published: November 2024

Knowing the structure of the crust is critical to understanding a planet's geologic evolution. Crustal thickness inversions rely on bulk density estimates, which are primarily affected by porosity. Due to the absence of high‐resolution gravity data, Mercury's crustal porosity has remained unknown. Here, we use a model that was calibrated to the Moon to relate Mercury's impact crater population and long‐wavelength crustal porosity in the cratered terrains. Therein, porosity is created by large impacts and then decreased as the surface ages due to pore compaction by smaller impacts and overburden pressure. Our models fit independent gravity‐derived porosity estimates in the northern regions, where data is well resolved. Porosity in the cratered terrains is found to be 9%–18% with an average and standard deviation of 13%  2%, indicating lunar‐like crustal bulk densities of 2,565 70 kg from which updated crustal thickness maps are constructed.
The Comprehensive Response of the Magnetopause to the Impact of an Isolated Magnetosheath High‐Speed Jet
Authors: Ma Jiuqi , Tang Binbin , Gao Xinliang , Li Wenya , Lu Quanming , Guo Wenlong , Guo Jin , Liu Huijie , Wang Chi
Published: November 2024

The magnetopause is the boundary between the Earth's magnetosphere and the solar wind. Magnetosheath high‐speed jets can impact the magnetopause, causing local indentation and subsequently rebound. However, the comprehensive response of the magnetopause to the impact of a high‐speed jet remains unclear. In this study, we establish that the full spatiotemporal response pattern of the magnetopause to the impact of an isolated magnetosheath high‐speed jet can be characterized as an “Indentation‐Rebounce‐Relaxation” sequence from a statistical view. Based on the pressure balance, we estimate the spatial and temporal scales of the entire response process to range from 0.5 to 3.2 Earth radii and 0.9–4.7 min, respectively. Furthermore, we find that the interaction between the magnetopause and the high‐speed jet during the rebounce phase distorts the magnetopause, subsequently generating pairs of field‐aligned currents. These generated field‐aligned currents may flow to the ionosphere, potentially contributing to magnetosphere‐ionosphere coupling.
Characteristics of Longitudinal Discontinuity Over Nighttime Equatorial Ionization Anomaly Crests With Multiple Observations
Authors: Chen Jiawen , Zhong Jiahao , Cai Xuguang , Hao Yongqiang , Cai Lei , Wan Xin , Li Qiaoling , Tang Zijing , Song Xingyan , Han Hao , Kuai Jiawei , Cai Lujin
Published: November 2024

Longitudinal discontinuity is observed over nighttime equatorial ionization anomaly (EIA) crests, characterized by a significant depletion between longitudes. Multiple observations, especially GOLD 135.6‐nm airglow images, are used to investigate the EIA discontinuity in details. Discontinuity events are found more likely to occur in one hemisphere, with a longitudinal width of tens of degrees and prolonged durations of several hours from 19 to 24 LT. The plasma depletion is most conspicuous at low altitudes, near or below the peak height. For the Atlantic sector, the EIA discontinuity is most prevalent between the March Equinox and the September Equinox, with an equinoctial asymmetry of higher occurrence rates around September Equinox. The climatological results indicate that field‐aligned trans‐hemispheric wind plays a predominant role in promoting the discontinuity, which transports the plasma from one hemisphere to the other hemisphere, resulting in potential localized depletion over the EIA crest.
Morphological and Hydrogeological Controls of Groundwater Flows and Water Age Distribution in Mountain Aquifers and Streams
Authors: Betterle A. , Bellin A.
Published: November 2024

Mountains are an essential source of the terrestrial component of the hydrological cycle, supplying high‐quality water to river networks and floodplain aquifers, especially during droughts. Traditionally, mountain hydrology has focused on shallow processes, overlooking the significance of deep‐seated rock formations due to characterization challenges. Recent field studies have revealed that fractured rock formations can host rich aquifers despite their low permeability. Nonetheless, it is unclear how deep flows interact with the overall hydrological functioning of mountain areas, how they contribute to the long‐term water budget, and how climate, morphology, and geology jointly control them. Through numerical simulations, we have gained new insights into mountain aquifers, addressing (a) the proportion of groundwater base flow and its age distribution, (b) water storage and its sensitivity to groundwater recharge, (c) the impact of long term mean recharge on the extent of the groundwater‐fed surface drainage network under various morphological and geological settings. We showed that subsurface travel times follow a Gamma distribution, whose parameters are modulated by recharge, hydraulic conductivity, and topography. High recharge and strong decay with depth of the hydraulic conductivity in a hilly topography lead to a shallow water table mimicking the surface topography and spatially distributed low‐intensity outflows that feed a dense drainage network. In rugged catchments, the groundwater contribution intensifies and concentrates in the downstream portion of the river network as recharge declines. These findings can help assess how a changing climate might impact hydrological regimes under various geomorphological conditions and identify sustainable water uses in mountain environments.
Ultra-fast light-field microscopy with event detection
Authors: Bian Liheng , Chang Xuyang , Xu Hanwen , Zhang Jun
Published: November 2024

The event detection technique has been introduced to light-field microscopy, boosting its imaging speed in orders of magnitude with simultaneous axial resolution enhancement in scattering medium.
Maternal and neonatal risks and outcomes after bariatric surgery: a comparative population based study across BMI categories in Qatar
Authors: Al-Dewik Nader I. , Samara Muthanna , Mahmah Adel , Al-Dewik Aseel , Abou Nahia Seba , Abukhadijah Hana J. , Samara Yahya , Hammuda Sara , Razzaq Aleem , Al-Dweik Manar R. , Alahersh Asma , Moamed Lina , Singh Rajvir , Al-Obaidly Sawsan , Olukade Tawa , Ismail Mohamed A. , Alnaama Alaa , Thomas Binny , Silang John Paul Ben , Nasrallah Gheyath , Rizk Nasser , Qoronfleh MWalid , AlAlami Usama , Farrell Thomas , Abdulrof Palli Valapila , AlQubaisi Mai , Al Rifai Hilal
Published: November 2024

The impact of Bariatric Surgery (BS) on maternal and neonatal outcomes among pregnant women is not fully understood, especially in comparison to different weight categories. The primary aim of this study is to assess the factors associated to women who have undergone BS. The study also investigates the maternal and neonatal outcomes amongst this group in comparison to the three Body Mass Index (BMI) groups (women with obesity, overweight and normal weight). A 12-month population-based retrospective study was conducted using registry data from the PEARL-Peristat Study at the Women's Wellness and Research Center (WWRC) in Qatar from January 1, 2017, through December 31, 2017. Both univariate and multivariable regression analyses were employed to scrutinize risk factors and maternal and neonatal outcomes. The study included 6212 parturient women, of which 315 had a history of BS, while 5897 with no BS history. Qatari women, aged 35 and higher, with parity > 1, diabetes, and hypertension were more likely to be in the post-BS group. Women in the post-BS group were found to be more likely to have a cesarean delivery (37.5% vs. 24%, Adjusted Odds Ratio (aOR) = 1.59, CI 1.18–2.14), preterm babies (10% vs. 7%, aOR = 1.66, CI 1.06–2.59), and stillbirth (1.6% vs. 0.4%, aOR = 4.53, CI 1.33–15.50) compared to the normal weight women group. Moreover, post-BS women had a higher risk of low-birth-weight neonates than women with obesity (15% vs. 8%, aOR = 1.77, CI 1.153–2.73), overweight (15% vs. 7%, aOR = 1.63, CI 1.09–2.43), and normal weight (15% vs. 8%, aOR = 1.838, CI 1.23–2.75). Finally, women in the post-BS group were more likely to have low-birth-weight neonates amongst term babies than women with obesity and overweight. Pregnancies with post-BS should be considered a high-risk group for certain medical outcomes and should be monitored closely. These findings may guide the future clinical decisions of antenatal and postnatal follow-up for post-BS women.
Floods of Egypt’s Nile in the 21st century
Authors: Badawy Ahmed , Sultan Mohamed , Abdelmohsen Karem , Yan Eugene , Elhaddad Hesham , Milewski Adam , Torres-Uribe Hugo E.
Published: November 2024

Extreme precipitation and flooding events are rising globally, necessitating a thorough understanding and sustainable management of water resources. One such setting is the Nile River’s source areas, where high precipitation has led to the filling of Lake Nasser (LN) twice (1998–2003; 2019–2022) in the last two decades and the diversion of overflow to depressions west of the Nile, where it is lost mainly to evaporation. Using temporal satellite-based data, climate models, and continuous rainfall-runoff models, we identified the primary contributor to increased runoff that reached LN in the past two decades and assessed the impact of climate change on the LN’s runoff throughout the twenty-first century. Findings include: (1) the Blue Nile subbasin (BNS) is the primary contributor to increased downstream runoff, (2) the BNS runoff was simulated in the twenty-first century using a calibrated (1965–1992) rainfall-runoff model with global circulation models (GCMs), CCSM4, HadGEM3, and GFDL-CM4.0, projections as model inputs, (3) the extreme value analysis for projected runoff driven by GCMs’ output indicates extreme floods are more severe in the twenty-first century, (4) one adaptation for the projected twenty-first century increase in precipitation (25–39%) and flood (2%-20%) extremes is to recharge Egypt’s fossil aquifers during high flood years.
Spin-Hall conductivity and optical characteristics of noncentrosymmetric quantum spin Hall insulators: the case of PbBiI
Authors: Mortezaei Nobahari Mohammad , Autieri Carmine
Published: November 2024

Quantum spin Hall insulators have attracted significant attention in recent years. Understanding the optical properties and spin Hall effect in these materials is crucial for technological advancements. In this study, we present theoretical analyses to explore the optical properties, Berry curvature and spin Hall conductivity of pristine and perturbed PbBiI using the linear combination of atomic orbitals and the Kubo formula. The system is not centrosymmetric and it is hosting at the same time Rashba spin-splitting and quantized spin Hall conductivity. Our calculations reveal that the electronic structure can be modified using staggered exchange fields and electric fields, leading to changes in the optical properties. Additionally, the spin Berry curvature and spin Hall conductivity are investigated as a function of the energy and temperature. The results indicate that due to the small dynamical spin Hall conductivity, generating an ac spin current in the PbBiI requires the use of external magnetic fields or magnetic materials.
Chitosan impregnated sugarcane bagasse biochar for removal of anionic dyes from wastewater
Authors: Akl Magda A. , Serage Asmaa A.
Published: November 2024

Wastewater treatment is of utmost importance in providing all equitable and safe drinking water. In the present study, a chitosan impregnated sugarcane bagasse biochar SCNC biocomposite has been synthesized for the removal of Congo red (CR) dye from an aqueous solution. The SCNC biocomposite was thoroughly characterized through Brunauer, Emmett and Teller (BET) and N2 adsorption isotherm, point of zero charge (pHPZC), elemental analysis, Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric analysis (TGA) analysis. Moreover, SCNC biocomposite was further employed to remove CR dye from the aqueous solution in batch mode. The SCNC biocomposite could remove more than 95.0% of CR at an initial concentration of (100mgL− 1), adsorbent dosage (0.05 g), time (200 min), pH ~ 3. The SCNC biocomposite achieved maximum adsorption capacity of 170mgg− 1. The equilibrium adsorption data for CR dye were best fitted to the Langmuir isotherm model with R2, 0.999. The kinetic and isotherm were statistically investigated using the chi-square statistic (χ2 ), mean square error (MSE), and the sum of squares error (SSE) Because of the higher correlation coefficient (R2 ≥ 0.999) and lower error functions, the equilibrium CR adsorption isotherms for a single-dye system fit Langmuir and the PSO kinetic model. The thermodynamic studies revealed the spontaneous and endothermic nature of adsorption of CR dye onto SCNC biocomposite. The SCNC biocomposite can be regenerated up to the 5th cycle successfully. The mechanism of CR adsorption onto SCNC was elucidated.
Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene
Authors: Kasprzak Artur , Żuchowska Agnieszka , Sakurai Hidehiro
Published: November 2024

Biological applications of sumanene buckybowl molecule have been widely discussed over the years yet remain still unexplored experimentally. On the other hand, creating cyclodextrin-containing supramolecular assemblies was demonstrated to be a powerful tool in terms of designing effective systems for medicinal chemistry purposes. Here, we show that sumanene molecule exclusively forms 1:1 host-guest complexes with γ-cyclodextrin (γCD) or (2-hydroxypropyl)-γ-cyclodextrin (HP-γCD), as revealed by extensive spectroscopic studies supported with density functional theory (DFT) computations. Based on our preliminary biological studies, we discovered that the formation of such complexes resulted in the improvement of anticancer properties of sumanene, expressed by high cell viabilities in vitro of healthy human mammary fibroblasts (HMF) together with low viabilities of human breast adenocarcinoma cells (MDA-MB-231). Improved pharmacokinetic (ADME-Tox) properties for sumanene@γCD and sumanene@HP-γCD complexes in comparison to native sumanene were also supported by in sillico modeling studies. This work provides the method how to focus the cytotoxic action of sumanene toward cancer cells using supramolecular assembly strategy, paving the way to the further exploration of biological properties of sumanene-containing supramolecular systems with bioactive features and applications of this buckybowl in general.
Machine learning for outcome prediction in patients with non-valvular atrial fibrillation from the GLORIA-AF registry
Authors: Joddrell Martha , El-Bouri Wahbi , Harrison Stephanie L. , Huisman Menno V. , Lip Gregory Y. H. , Zheng Yalin ,   GLORIA-AFinvestigators
Published: November 2024

Clinical risk scores that predict outcomes in patients with atrial fibrillation (AF) have modest predictive value. Machine learning (ML) may achieve greater results when predicting adverse outcomes in patients with recently diagnosed AF. Several ML models were tested and compared with current clinical risk scores on a cohort of 26,183 patients (mean age 70.13 (standard deviation 10.13); 44.8% female) with non-valvular AF. Inputted into the ML models were 23 demographic variables alongside comorbidities and current treatments. For one-year stroke prediction, ML achieved an area under the curve (AUC) of 0.653 (95% confidence interval 0.576–0.730), compared to the CHADS2 and CHA2DS2-VASc scores performance of 0.587 (95% CI 0.559–0.615) and 0.535 (95% CI 0.521–0.550), respectively. Using ML for one-year major bleed prediction increased the AUC from 0.537 (95% CI 0.518–0.557) generated by the HAS-BLED score to 0.677 (95% CI 0.619–0.724). ML was able to predict one-year and three-year all-cause mortality with an AUC of 0.734 (95% CI 0.696–0.771) and 0.742 (95% CI 0.718–0.766). In this study a significant improvement in performance was observed when transitioning from clinical risk scores to machine learning-based approaches across all applications tested. Obtaining precise prediction tools is desirable for increased interventions to reduce event rates.

Trial Registryhttps://www.clinicaltrials.gov; Unique identifier: NCT01468701, NCT01671007, NCT01937377.
Quantum dot-based biomimetic fluorescence immunoassays for enrofloxacin detection in animal-derived foods
Authors: Hu Gaoshuang , Liu Ziyang , Zhang Yiqin , Zhao Tao , Xing Zhuqing , Gao Shan , Hao Jianxiong
Published: November 2024

Schematic illustration of biomimetic fluorescence immunoassays based on QDs.
Trapping in situ generated CF3-nitrile imines with maleimides under solvent-free mechanochemical conditions
Authors: Utecht-Jarzyńska Greta , Jarzyński Szymon , Jasiński Marcin
Published: November 2024

A series of trifluoromethylated pyrrolo[3,4-c]pyrazoles were obtained via mechanochemical (3 + 2)-cycloaddition of in situ generated trifluoroacetonitrile imines with maleimide and its N-aliphatic/aromatic analogues.
Correction: Improved isoprene detection performance of Si-doped WO3 films deposited by sputtering and post-annealing
Authors: Lin Pin-Kuan , Qin Yi , Qi Xiaoding , Huang Liji
Published: November 2024

Correction for ‘Improved isoprene detection performance of Si-doped WO3 films deposited by sputtering and post-annealing’ by Pin-Kuan Lin et al., RSC Adv., 2024, 14, 13618–13627, https://doi.org/10.1039/D4RA00184B.
Tuning recombination and charge separation in a n/p/p heterojunction solar cell with CZTS, Ag3SbS3 and a carbon interlayer
Authors: Naidu Ponnada Yallam , Ojha Manoranjan , Naskar Souvik , Deepa Melepurath
Published: November 2024

An n/p/p heterojunction solar cell taps the synergy between the photosensitizers: CdS (n-type) and CZTS (p-type) nanocrystals and Ag3SbS3 (p-type) quantum dots to yield an efficiency of 9.76%.