bluuebunny/crossref_metadata_2025 huggingface dataset:
Reliability and validity of a four-level severity score based triage scale
Authors: Josse Constance , Brodeur Sarah , Callahan Jean-Christophe
Published: November 2019

Background:Triage scales are essential tools for an early and rapid assessment of patients, by classifying them according to their degree of urgency. The objective of this study was to measure the reliability and validity of a four-level severity score based scale.Methods:To evaluate reliability, 250 triage forms were triaged by 6 triage nurses twice, 15 days apart. Intra and inter-rater reproducibility were measured using a weighted Cohen’s Kappa. For the validity study, 485 charts were evaluated. The relationship between triage level and emergency department resource consumption was measured using Spearman’s correlation coefficient. Prediction of severity was measured by the correlation between triage level and hospitalization in any ward, and between triage level and death in the emergency department or hospitalization in an intensive care or high dependency unit. Areas under the ROC curves were measured for these results.Results:For inter-rater reproducibility, the weighted Kappa was measured at 0.51 (95% CI 0.30 – 0.70), and 0.67 (95% CI 0.42 – 0.91) for intra-rater reproducibility. 474 patients were recruited in the validity study, respectively 26 (5%), 50 (11%), 384 (81%) and 14 (3%) for triage levels 1 through 4. Spearman’s correlation coefficient between triage level and emergency department resource consumption was calculated at R = -0.41 (p<0.001). 111 patients were admitted to the hospital with an area under the ROC curve measured at 0.72. 8 patients were admitted to an intensive care or high dependency unit with an area under the ROC curve measured at 0.73.Conclusions:Our study of a four-level severity score based triage scale finds intermediate results in terms of reliability and validity. Further improvements of the scale have to focus on better discriminating between moderately urgent and non-urgent patients.
Community Stakeholder’s Perceptions of the Core Components of a Pediatric Weight Management Intervention
Authors: Fiechtner Lauren , Castro Ines , Simione Meg , O'Connor Giselle , Sharifi Mona , Harris Camille , Gonzalez Vanessa , Perkins Meghan , Torres Shioban , Taveras Elsie , Kuhlthau Karen
Published: November 2019

Background: Multi-sector stakeholder engagement is essential in understanding what is needed for the implementation, dissemination and sustainability of pediatric weight management interventions (PWMI).Methods: We sought to examine the perspectives of stakeholders during the pre-implementation period of a two-arm, PWMI randomized controlled trial (RCT) in federally qualified health centers and YMCAs. We conducted the interviews prior to the implementation of the RCT and reached thematic saturation. Interviews were transcribed and coded using the Consolidated Framework for Implementation Research (CFIR) approach as the intent of the trial was to observe implementation and efficacy outcomes. Our aims were (1) to understand the core components needed for a successful PWMI and (2) to identify determinants and barriers to implementation and future wide-scale dissemination. We conducted the interviews prior to the implementation of the RCT and reached thematic saturation after interviewing 26 stakeholders representing 13 groups. Interviews were transcribed and coded using the framework analysis approach.Results and discussion: We identified themes that stakeholders perceived as core components of a PWMI: a formal curriculum with illustrative examples for patients (i.e. demonstrating how much sugar is in sugary beverages), a patient and family centered program, group visits, and inclusion of high-quality core personnel such as a community health worker, a physician, a behavior health clinician and a dietitian. Determinants of successful implementation and dissemination included partnerships among community and clinical organizations, sustained funding, supportive policies such as insurance reimbursement for community health workers and dietitians, and identifying and addressing needs of dissemination sites, and identifying and addressing patient barriers. These findings helped to identify the core components required for PWMIs and how best to address key determinants affecting implementation and dissemination. Trial registration: ClinicalTrials.gov: NCT03012126; registration date: 12 December 2016, https://clinicaltrials.gov/ct2/show/NCT03012126
iTRAQ-based Comparative Proteomic Analysis of Flag Leaves of Two Wheat (Triticum aestivum L.) Genotypes Differing in Waterlogging Tolerance at Anthesis
Authors: Wei Mingmei , Li LiuLong , Xie Ke , Yang Rui , Wang Xiaoyan , Sha Aihua
Published: November 2019

Background : Waterlogging is one of the major abiotic stresses limiting wheat product. Plants can adapt to waterlogging with changes in morphology, anatomy, and metabolism. Many genes and proteins play critical roles in adaptation to waterlogging.

Results : in this study, the iTRAQ-based proteomic strategy was applied to identify the waterlogging-responsive proteins in wheat. A total of 7,710 proteins were identified in two wheat varieties, XM55 (waterlogging-tolerant) and YM158 (waterlogging-sensitive), at anthesis under waterlogging or not. Sixteen proteins were differentially accumulated between XM55 and YM158 under waterlogging with cultivar specificity. Of these, 11 proteins were up-regulated and 5 proteins were down-regulated. The up-regulated proteins included Fe-S cluster assembly factor, heat shock cognate 70, GTP-binding protein SAR1A-like, and CBS domain-containing protein. The down-regulated proteins contained photosystem II reaction center protein H, carotenoid 9,10 (9',10')-cleavage dioxygenase-like, psbP-like protein 1, and mitochondrial ATPase inhibitor. In addition, 9 proteins were responsive to waterlogging with non-cultivar specificity. These proteins included 3-isopropylmalate dehydratase large subunit, solanesyl-diphosphate synthase 2, DEAD-box ATP-dependent RNA helicase 3, and 3 predicted or uncharacterized proteins. Sixteen out of the 28 selected proteins showed consistent expression patterns between mRNA and protein levels.

Conclusion s: This study revealed that the proteins were differential accumulated between the two contrast waterlogging wheat varieties in response to waterlogging, which provide valuable insights into wheat response to waterlogging stress. The identified differentially accumulated protein might be applied to develop waterlogging tolerant wheat.
Anais Congresso da Saúde UNIFIO
Authors: Foratori-Junior Gerson Aparecido , Souza Juliana Moura Storniolo , Souza Adriana Lucas da Luz , Custódio Daiane Graciano , Gimenes Daniel Salesi , Butafava Gabriela , Crosatti Isabela , Kuindy Jéssica Beatriz de Almeida , Rodrigues Jhennifer Lopes , Fantine Karoline , Veiga Laura da Silva , Pimentel Rayssa Garcia , Martins Tálita Florêncio Guedes , Baggio Vitor Rabelo
Published: November 2019

EditorialCaro(a) Leitor(a)Nos dias 23, 24 e 25 de abril de 2019 realizou-se no campus do Centro Universitário das Faculdades Integradas de Ourinhos – UNIFIO o I Congresso da Saúde, que contou com a participação dos cursos de Biomedicina, Enfermagem, Farmácia, Fisioterapia, Nutrição e Odontologia e com foco direcionado aos alunos e profissionais.Este evento teve como objetivo promover cursos multidisciplinares que foram ministrados por professores renomados, os quais trouxeram atualização para os alunos e profissionais participantes tanto no âmbito da prática clínica quanto da pesquisa científica.Além da grade científica baseada nas mais atuais evidências, os alunos do curso de Odontologia tiveram a oportunidade de apresentar trabalhos científicos na forma de painel e oral. Contamos também com a participação de alunos de graduação e pós-graduação de instituições externas, além de profissionais de odontologia de Ourinhos e região.Prof. Me. Gerson Aparecido Foratori JuniorDocente Coordenador do Congresso na Área de Odontologia
Abortion Categories and Characteristics of Acarpous Crape Myrtle Floral Organs
Authors: Zhou Wei , Wang Xiaoming , Chen Jianhua , Chen Liangming , Qiao Zhongquan , Zeng Huijie
Published: November 2019

Lagerstroemia indica (crape myrtle) is a popular Chinese landscape plant with a long flowering period that contributes to its gorgeous flowers and high ornamental value, which motivate L. indica breeding. We found a wild acarpous individual of L. indica that did not bear seeds after flowering and had a significantly longer flowering period than fructiferous L. indica. This study identified differences in floral organ morphology, and stamen and pistil structure between fructiferous and acarpous L. indica through observation, paraffin sectioning, and scanning electron microscopy (SEM). The flowering time of each acarpous L. indica inflorescence lasts as long as 18 to 25 days. When a single flower withers, it falls from the pedicel without any fruit. The abortion in the floral organ of acarpous L. indica is characterized by sterile and undehisced anthers, pollen abortion, and deformed and irregularly arranged filament cells. Acarpous L. indica features short and loosely arranged papilla cells in the stigma, a flat style and narrow stylar canal, loosely arranged epidermal cells, and no obvious nuclei. No embryo sac cavity is found in acarpous L. indica ovules. In some nucelli, the egg apparatus structure can be observed indistinctly but without cell contour. In others, the egg apparatus structure is completely absent, and only flocculent tissue is observed. This study may provide a theoretical foundation for future studies on the molecular mechanisms of the mutations in acarpous L. indica.
A PERSONALIZED APPROACH TO ADJUVANT CHEMOTHERAPY FOR NON-SMALL CELL LUNG CANCER AFTER RADICAL SURGICAL TREATMENT BASED ON MOLECULAR MARKERS OF CHEMOSENSITIVITY
Authors: Efteev L. A. , Rodionov E. O. , Miller S. V. , Tuzikov S. A. , Tsyganov M. M. , Deryusheva I. V. , Litvyakov N. V. , Frolova I. G.
Published: November 2019

Despite advances in the treatment of non-small cell lung cancer (NSC LC), prognosis of advanced lung cancer is extremely poor. The search for additional treatment options to prevent local recurrence and distant metastases is of great importance. Monoresistance genes, such as ABCC5, BRCA1, RRM1, ERCC1, TOP1, TOP2a, TUBB3, and TYMS play a significant role in tumor sensitivity to chemotherapy for NSC LC. The expression levels of these genes in tumor tissue should be assessed for personalization of adjuvant chemotherapy in patients with NSC LC.

Case description. We present a clinical case of a 65-year-old patient diagnosed with non-small cell lung cancer who underwent extended combined surgery followed by 4 courses of personalized adjuvant chemotherapy. The expression levels of monoresistance genes (ABCC5, RRM1, ERCC1, TOP1, TOP2a, TUBB3, BRCA 1 and TYMS) determined by reverse-transcriptase quantitative real-time PCR (RTqPCR) were used as predictive markers of response to adjuvant chemotherapy regimen.

Conclusion. Our case report demonstrated the feasibility of performing organ-preserving surgery followed by personalized adjuvant chemotherapy based on the expression levels of monoresistance genes as predictive markers of benefit from adjuvant chemotherapy.
SOLID PSEUDOPAPILLARY TUMOR OF THE PANCREAS IN A MAN: A CASE REPORT
Authors: Shabunin A. V. , Tavobilov M. M. , Paklina O. V. , Setdikova G. R. , Karpov A. A. , Ozerova D. S.
Published: November 2019

Background. Solid pseudopapillary tumor of the pancreas is a rare neoplasm, accounting for only 1–2 % of all pancreatic neoplasms and having a tendency to affect mainly young women.

Material and methods. We report a case of a solid pseudopapillary tumor of the pancreas in a 28-year-old man treated with laparoscopic distal pancreatectomy in Moscow Botkin Hospital.

Results. The tumor was discovered incidentally by routine survey ultrasound or computed tomography of the abdomen. The patient underwent distal pancreatectomy with splenectomy. The immunohistochemical study showed a pronounced positive nuclear staining for β-catenin and progesterone and a negative staining for chromogranin A and synaptophysin, thus confirming the presence of solid pseudopapillary tumor of the pancreas.

Conclusion. In case of pancreatic tumor, even in male patients, a solid pseudopapillary tumor must be considered in the differential diagnosis. Surgical strategies should be based on the location, size of the tumor and the involvement of adjacent organs, because R0-resection with a solid pseudopapillary tumor leads to a good 5-year survival.
INCIDENCE AND MORTALITY OF CERVICAL CANCER IN THE OMSK REGION
Authors: Goleva O. P. , Tasova Z. B. , Prudnikova O. P.
Published: November 2019

The purpose of the study was a comparative assessment of the cervical cancer incidence and mortality among females in urban and rural populations of the Omsk region.

Material and Methods. The study included females aged over 18 years from urban and rural areas of the Omsk region. According to population-based cancer registry data for the period 2004–16, the crude cancer incidence and mortality rates in urban and rural populations were calculated. The variational and correlation analyzes were used, the differences were assessed using Student t-test.

Results. During 2004–16, the cervical cancer incidence among females of the Omsk region showed an increasing tendency, reaching a peak incidence in women aged 35–54. Concerning the cervical cancer mortality rate, it tended to decrease. For rural females, the cervical cancer mortality rate decreased from 10.8 to 9.7 per 100,000 females (p>0.05). For urban females, the mortality rate decreased from 9.2 to 7.5 per 100,000 females (p>0.05). No significant differences in the mortality rates between urban and rural females were found (p>0.05). The tendency towards decreased incidence of advanced cervical cancer (the average decrease being 3.3 % for rural females and 2.8 % for urban females, p>0.05) and increased incidence of early stage cervical cancer (the average rise being 1.8 % and 1.9 %, respectively) was observed.

Conclusion. In the Omsk region, the cervical cancer mortality rate for both rural and urban females showed a tendency to decrease. During the study period, the incidence of cervical cancer had increased; however the incidence of advanced cervical cancer had decreased.
CLINICAL OPTIONS FOR METABOLIC SYNDROME IN PATIENTS WITH ENDOMETRIAL CANCER
Authors: Kishkina A. Yu. , Kolomiets L. A. , Yunusova N. V.
Published: November 2019

Many epidemiological studies have revealed the association between the risk of developing endometrial cancer (EС) and metabolic syndrome (MS) components. A large percentage of patients, especially elderly patients, may have one or more MS components at the time of cancer diagnosis.

Objective: to identify the clinical and morphological features of EС, depending on the number of MS components: three-, fourand five-components.

Material and Methods. The study included 60 patients with morphologically verified endometrial cancer (T1–3aN0–1M0). All endometrial cancer patients were divided into three groups. Group I included patients with MS, group II – patients with obesity or overweight (ICU ), and group III – patients without MS. Endometrial cancer patients with MS were divided into three subgroups: patients with 3 MS components, with 4 MS components and with 5 MS components.

Results. The proportion of endometrial cancer patients with MS was 53.3 %. The median age of the patients was 61.0 ± 2.1 years. The majority of patients had 4 components of MS. Moderately differentiated tumor was observed in 71.8 % of cases, and invasion of less than one-half of the myometrium was observed in 65.3 % of cases. Significant factors of relapse-free survival were: the presence/absence of MS, TG level and the fasting plasma glucose level, thus underlining the effect of MS not only on the development of EС, but also the survival of patients.

Conclusions. Our study and many previous studies indicate that the strategies for reducing the prevalence of the components of MS are needed to be developed.
BREAST CANCER TYPING USING RT-PCR ASSAY
Authors: Bozhenko V. K. , Trotsenko I. D. , Kudimnova E. A. , Vardanyan S. G. , Zakharenko M. V. , Solodky V. A. , Makarova M. V.
Published: November 2019

Introduction. Adjuvant systemic therapy remains one of the main options for treating breast cancer. Results of standard immunohistochemical studies are not always a criterion for selecting systemic therapy. Nowadays, multigene expression analysis is actively used to predict the response to chemotherapy in patients with earlystage breast cancer. We studied a 24-gene multi-gene panel for typing breast cancer.

Material and Methods. A prospective analysis of 199 breast cancer patients (T1–3N0–3M0) was carried out. Surgical specimens were studied using the standard immunohistochemistry (IHC) and RT-PCR for detecting expression of 24 genes.

Results. According to the IHC results, breast cancer was divided into 5 molecular subtypes: luminal A was detected in 59 (30 %) patients; luminal B (HER2-negative) in 52 (26 %); luminal B (HER2-positive) in 19 (9 %); triple-negative in 28 (14 %); HER2-positive 41 (21 %). RT-PCR showed that ST K15, MYC, MYBL2, BIRCC 5, BCL2, TERT, ESRP1, PGR, HER2, GBR7, MGB1 and MMP11 were the most significant genes in subtype distribution. The total percentage of matches between the two studies was 61.7 %.

Conclusion. Studies have shown the need to add additional typing methods for breast cancer to a standard IHC study, which will undoubtedly increase the information content of diagnostic measures and will improve the effectiveness of the treatment.
STUDY OF THE DNA DAMAGE IN HeLa CELLS EXPOSED TO THE COMBINATION OF ULTRASOUND AND 5-FLUORURACYL
Authors: Frantsiyants E. M. , Surikova E. I. , Goroshinskaya I. A. , Moiseenko T. I. , Nazaralieva N. A. , Potemkin D. S. , Vasilchenko N. G.
Published: November 2019

To understand the mechanism of the effect of 5 % 5-fluorouracil (5-FU) gel used simultaneously with ultrasound (US ) on a tumor in patients with cervical cancer, the level of DNA damage was studied in vitro. We used cervical adenocarcinoma HeLa CC L-2 cells cultured under standard conditions in RPMI-1640 medium with 10 % fetal bovine serum and 50 μg / ml gentamicin. Ultrasound exposure lasted 10 min. (frequency of 0.88 MHz and intensity of 0.2 W / cm2). The 5-FU dose was 0.7 мкМ, with the time of exposure of 24 hours. In 24 hours after starting exposure, the level of DNA damage to the cells of the culture was studied using the comet assay in the alkaline version and evaluated by the % DNA parameter in the comet tail (% TDNA). The statistical significance of the differences was evaluated using the Mann-Whitney U test and Fisher’s exact test. The combined exposure to ultrasound / 5-FU led to a 5.2-fold increase in % TDNA compared to the control culture, % TDNA was 1.9 times higher after exposure to 5-FU alone and 3.0 times higher after exposure to ultrasound alone. In 24 hours after the combined exposure, less than 50 % of the culture cells had a low level of DNA damage (<10 % TDNA), i.e. completed the repair process and could continue to proliferate, and more than 30 % of the culture cells still had a high level of damage (>30 % TDNA) and were probably in the process of apoptosis. Thus, the results of the study showed that the combined effect of ultrasound / 5-FU on the HeLa culture helped to overcome resistance to chemotherapy, having a synergistic effect.
ADVANCED LARYNGEAL CANCER (LITERATURE REVIEW)
Authors: Radzhabova Z. A-G. , Kotov M. A. , Ebert M. A. , Mitrophanov A. S. , Radzhabova M. A. , Levchenko E. V.
Published: November 2019

Background. Squamous carcinoma of the larynx is still the most common head and neck cancer in many Western countries. The larynx plays a key role for many essential functions, including breathing, voice production, airway protection, and swallowing. According to the world literature, 23,800 new cases of laryngeal cancer and 106,000 deaths from this disease are registered annually in the world. Laryngeal cancer treatment is aimed at achieving tumor control while optimizing functional outcomes.

Objective: to review available data on surgical and non-surgical treatment options for locally advanced laryngeal cancer, as well as the evidence supporting each of these, including oncological outcomes (overall survival, disease-free survival, local control of the disease, functional outcomes and quality of life).

Material and Methods. A systematic literature search was conducted in the electronic databases Medline, Cochrane Library, and Elibrary in the interval time between 1987 and 2016.

Conclusions. In recent decades, the treatment paradigm for advanced laryngeal cancer has shifted from surgery (total laryngectomy) as the gold standard of treatment to nonsurgical organ-preserving treatment using radiation therapy or chemoradiation therapy. However, concerns have arisen regarding functional outcomes after chemoradiation therapy, as well as a possible reduction in overall survival in laryngeal cancer patients, risk factors, laryngectomy.
The Source of Toxicity of Backwash Water from a Swimming Pool Filter Bed Washings
Authors: LEMPART Anna , KUDLEK Edyta , DUDZIAK Mariusz , ZAWADZKA Aleksandra
Published: November 2019

The necessity of reducing the operating costs of swimming pools leads to attempts to reuse of backwash water from washing swimming pool filter beds. Their use for watering plants, sprinkling tennis courts and play fields, draining to nearby watercourses or even returning to swimming pool installations is taken into consideration. Current researches proved the toxicity of these waste streams. The results of these studies raise doubts about the rightness of the attempts to introduce washings from pool filters directly into the environment. The aim of the presented work is to determine the source of toxicity of filter backwash water. The assessed in the work washings were characterized by high turbidity, high content of both suspended solids and organic compounds. A decrease in value of general impurity indicators after the filtration process of washings has been shown, suggesting that the main source of toxicity may be the suspension, including various anthropogenic organic micropollutants. Although this is just a research hypothesis. For this reason, comparative studies on the occurrence of toxic organic micropollutants in raw filter backwash water, supernatant water and filtrate collected after the filtration process were carried out.
THE IMPORTANCE OF COLOUR AND TEXTURE IN THE DESIGN OF RESIDENTIAL INTERIORS, WITH A PARTICULAR FOCUS ON KITCHENS FOR THE VISUALLY IMPAIRED PEOPLE
Authors: KASZUBA Joanna , SOBCZYŃSKA Karolina
Published: November 2019

People with visual impairments make up a very large part of society. Elderly people, as well as children and young people, are affected by sight impairments that sometimes continue until they lose their sight. These people should be facilitated as to their functioning in the environment through appropriate space design. It is reasonable and advisable to adapt the living quarters in particular to meet their needs. In this study, the authors investigated the preferences for colours and textures in living space, with particular emphasis on the kitchen.
TRADITION AND INNOVATION IN SERBIAN 21ST CENTURY ARCHITECTURE – THE NATURAL, STRUCTURAL MATERIALS’ IMPACT ON THE HUMAN BEING
Authors: MILOŠEVIĆ Predrag , MILOŠEVIĆ Vladimir , MILOŠEVIĆ Grigor
Published: November 2019

The aim of this paper is to illustrate what is happening at present in Serbia through the analysis of traditional Serbian construction, i.e. the technique and the conditions under which it was created. However, as the reality of the subject is quite cruel in today's time, this paper seeks to show the value of the principles on which traditional architecture rests, primarily through the use of natural materials in construction. The reason for this is the inextricable link between man and nature, the very essence of their interconnectedness, as well as the creation of a healthy, aesthetically valuable and quality living space. Based on these analyses, many conceptual solutions will be attached, i.e. the proposal of contemporary interpretation of certain traditional Serbian houses that can meet the needs of modern man and age, where old tradition is implemented in contemporary Serbian architecture.
A CONCEPT OF THE GASIFICATION PLANT FOR SELECTED ORGANIC WASTE
Authors: CZOP Monika
Published: November 2019

It is observed that in the world economy the consumption of the natural resources increases which results in the growth of a stream of municipal and industrial waste. Both of these phenomena belong to the most important civilization problems. One of the potential directions of the waste management should be the recovery of energy from the combustible fraction. One of the possibilities to convert energy from waste into usable power is gasification, i.e. transformation of the municipal waste into syngas. The paper presents a concept of a gasification plant for gasification of selected organic waste. Tests were conducted for selected fractions from the stream of municipal waste. Simulation calculations of the gasification process were performed with the help of software ChemCAD 7.0.0.
Calibration method for large-aperture digital antenna array
Authors: Shishov Yu. A. , Gubanov D. V. , Vahlov M. G. , Balashov V. M.
Published: November 2019

Вased on the analysis of known technical solutions, the article proposes a method for calibrating the large-aperture receiving AESA radar for early warning. The peculiarity of this technique is that a coherent radio pulse sequence is applied as the calibration signal supplied to the inputs of the receiving modules. The power of each of the radio pulses is of the same order as the power of the signals arriving at the inputs of the receiving modules when the radar is operating normally, that is, with the signal-to-noise ratio at the input of the AFAR receiving module of 10-6-10-3. Thus, the calibration should occur in the region of small signals, within the working dynamic range. The technical implementation of this technique allows to obtain a higher accuracy of the calibration of the AESA while simplifying the design of the receiving modules, compared with similar technical solutions.
Technique for improving quality of functioning of a self-oscillating micromechanical accelerometer
Authors: Aman E. E.
Published: November 2019

Currently the manufacture of small-size unmanned flying vehicles is actively developed; that leads to a necessity of creating reliable and precise microelectromechanical sensors. Many of them can operate under strictly determined conditions. The presented methodology allows creating sensors in such a way that they can preserve small sizes and basic quality parameters under various operation conditions. Due to the presence of magnetic elements it is necessary to take into account the influence of an external magnetic field, for it is able to seriously interfere with the operation of the sensor and lead to inaccurate measurement results, and paths with current are able to increase temperature in a closed volume of the device housing, which will affect its static and power characteristics. The choice of geometric parameters and materials for manufacture of the magnetic screen, the method of reduction and elimination of thermal effects has been substantiated.
Research of corrosion stability of steel brand 12X18H10T and titanium brand ВT1–0 for solder baths
Authors: Tourkina N. R. , Vishneva N. V.
Published: November 2019

General global trend of reduce the proportion of physical experiment when designing equipment led to an increase in the significance of the calculation and to tighten the requirements for its conduct. The study was carried out corrosion resistance of steel brand 12X18H10T and titanium brand ВT1–0 for solder baths. Based on the experiments of corrosivity was concluded that preparing the metal surface of the solder baths is a determining factor. Corrosion of the samples was uneven over the entire surface, the main corrosivity is manifested during the first 50 hours. Further etching of the samples leads to a slow decrease in the corrosion rate with the exit to the plateau. Thanks to this study, it has been established that steel brand 12X18H10T and titanium brand ВT1–0 are acceptable structural materials and are proposed for use in mass production.
Development of indoor monitoring and control modules for people with disabilities
Authors: Borsuk N. A. , Fedorova V. A. , Ivanov M. V.
Published: November 2019

Some questions of socialization of physically disabled people are considered, the concept Smart home, its opportunities is given. The conclusion is drawn on need of development of a specialized system of the climate security module and module of monitoring of location of the disabled person indoors. Features of the solution of this task are considered. For a possible solution to this problem, a set of video surveillance equipment is offered which can be composed of: cameras, server – computer, data storage, router for wireless devices, and specialized software, the core of the video surveillance system, operating system, video analysis modules and integration with third-party software systems, etc. When using only one router, a solution to the problem of tracking the correct location of the receiver in cases where, for example, the user walks in a circle is proposed. The realization option is offered.
Description of technological level of development of software systems for management of unmanned aerial vehicle groupings at domestic aircraft instrument manufacturing enterprises
Authors: Smirnova M. S.
Published: November 2019

The article analyzes the state of the level of development of software systems for managing groups of unmanned aerial vehicles at domestic enterprises. The dominant technological paradigm for the development of software systems for managing groups of unmanned aerial vehicles has been determined. The article compares the hardware platforms, on the basis of which the software systems of products manufactured by «NPP Radar mms» JSC, «Vega Radio Engineering Concern» JSC, «Kronstadt Technologies» JSC, «AEROKON» JSC, «Autonomous Aerospace Systems NPO LLC GeoService», provides a brief description of the capabilities of the complexes. As a hypothesis, the article discusses the possibility of using the SCRUM technological system for developing application software for software systems for managing groups of unmanned aerial vehicles. It is determined in the work that the level of microelectronic and radio-technical components used determines the possibilities that are realized in the applied functionality of software complexes for controlling the groupings of unmanned aerial vehicles.
Mapping as element of production process management effectiveness at an enterprise
Authors: Aleshkin N. A. , Aleshkin A. P.
Published: November 2019

The constant increase in the requirements for the quality of the products produced, as well as the production processes at the enterprise, and the increased competition from the contractual products force industrial enterprises to constantly find ways to increase the efficiency of their activities. The problem of improving the production system of machine-building enterprises is of particular relevance in the conditions set for the industry’s strategic goals of creating a high-performance sector, developing on the basis of modern technology and provided with highly qualified personnel. The program of the Government of theRussian Federation«Development of the industry and improvement of its competitiveness» approved in 2014 also demonstrates the strategic focus of the development of the manufacturing sector. According to this program the machine-building complex will receive additional funding for the formation of high-tech, competitive industries.
The Effects of Resistance Exercise With Blood Flow Restriction on Flow-Mediated Dilation and Arterial Stiffness in Elderly People With Low Gait Speed: Protocol for a Randomized Controlled Trial
Authors: Amorim Samuel , Degens Hans , Passos Gaspar Alexandra , De Matos Luciana Diniz Nagem Janot
Published: November 2019

Background

During aging, a significant loss of muscle mass, strength, and power is associated with a decline in daily functional capacities. Traditionally, resistance training is prescribed to prevent or reverse the skeletal muscle weakness, but the required training intensity may be too demanding for older people with poor physical performance. Resistance exercise with blood flow moderation (KAATSU training), originally developed in Japan, combines resistance exercise with blood flow restriction. It has been reported that KAATSU training enhances muscle hypertrophy in many populations. However, few studies have evaluated the effects of resistance exercises with blood flow restriction in elderly people and how this affects vascular structure and function.

Objective

The aim of this study was to evaluate (1) the acute and chronic effects of resistance exercise with blood flow restriction on vascular health in elderly people with low gait speed and (2) whether low-load resistance training with blood flow restriction elicits similar strength and gait speed gains to those elicited by conventional resistance training without blood flow restriction.

Methods

This is an ongoing randomized controlled trial in elderly people with low gait speed. Overall, two study arms of 13 participants each perform resistance exercise with and without blood flow restriction. The 2 groups are as follows: the control group will perform conventional resistance exercise (60% of 1 repetition maximum) and the KAATSU group will perform the low-load resistance exercise with blood flow restriction (20% of 1 repetition maximum) for 12 weeks. Pulse wave velocity, venous occlusion plethysmography, and flow-mediated dilation are used to assess arterial stiffness, muscle blood flow, and endothelial function, respectively. The secondary outcomes are gait speed, strength, and quality of life. All measures will be performed before and after the training program.

Results

This research study is in progress. Recruitment has started, and data collection is expected to finish in August 2020.

Conclusions

The findings of this study will have important implications for the rehabilitation of elderly people.

Trial Registration

ClinicalTrials.gov NCT03272737; https://clinicaltrials.gov/ct2/show/NCT03272737

International Registered Report Identifier (IRRID)

DERR1-10.2196/14691
Evaluating the Efficacy of Internet-Delivered Cognitive Behavioral Therapy Blended With Synchronous Chat Sessions to Treat Adolescent Depression: Randomized Controlled Trial (Preprint)
Authors: Topooco Naira , Byléhn Sandra , Dahlström Nysäter Ellen , Holmlund Jenny , Lindegaard Johanna , Johansson Sanna , Åberg Linnea , Bergman Nordgren Lise , Zetterqvist Maria , Andersson Gerhard
Published: November 2019

BACKGROUND

Depression is a common and serious problem among adolescents, but few seek or have access to therapy. Internet-delivered cognitive behavioral therapies (ICBTs), developed to increase treatment access, show promise in reducing depression. The inclusion of coach support in treatment is desired and may be needed.

OBJECTIVE

The aim of this study was to determine the efficacy of an ICBT protocol blended with weekly real-time therapist sessions via chat; blended treatment, for adolescent depression, including major depressive episode (MDE). The protocol has previously been evaluated in a controlled study.

METHODS

In a two-arm randomized controlled trial, adolescents 15 to 19 years of age were recruited through a community setting at the national level in Sweden (n=70) and allocated to either 8 weeks of treatment or to minimal attention control. Depression was assessed at baseline, at posttreatment, and at 12 months following treatment (in the intervention group). The primary outcome was self-reported depression level as measured with the Beck Depression Inventory II at posttreatment. The intervention was offered without the need for parental consent.

RESULTS

Over two weeks, 162 adolescents registered and completed the baseline screening. Eligible participants (n=70) were on average 17.5 years of age (SD 1.15), female (96%, 67/70), suffered from MDE (76%, 53/70), had no previous treatment experience (64%, 45/70), and reported guardian(s) to be aware about their depression state (71%, 50/70). The average intervention completion was 74% (11.8 of 16 modules and sessions). Following the treatment, ICBT participants demonstrated a significant decrease in depression symptoms compared with controls (P<.001), corresponding to a large between-group effect (intention-to-treat analysis: d=0.86, 95% CI 0.37-1.35; of completer analysis: d=0.99, 95% CI 0.48-1.51). A significant between-group effect was observed in the secondary depression outcome (P=.003); clinically significant improvement was found in 46% (16/35) of ICBT participants compared with 11% (4/35) in the control group (P=.001).

CONCLUSIONS

The results are in line with our previous study, further demonstrating that adolescents with depression can successfully be engaged in and experience significant improvement following ICBT blended with therapist chat sessions. Findings on participants’ age and baseline depression severity are of interest in relation to used study methods.

CLINICALTRIAL

ClinicalTrials.gov NCT02363205; https://clinicaltrials.gov/ct2/show/NCT02363205
Understanding Nursing Workflow for Inpatient Education Delivery: Time and Motion Study (Preprint)
Authors: Baker Kelley M , Magee Michelle F , Smith Kelly M
Published: November 2019

BACKGROUND

Diabetes self-management education and support improves diabetes-related outcomes, but many persons living with diabetes do not receive this. Adults with diabetes have high hospitalization rates, so hospital stays may present an opportunity for diabetes education. Nurses, supported by patient care technicians, are typically responsible for delivering patient education but often do not have time. Using technology to support education delivery in the hospital is one potentially important solution.

OBJECTIVE

The aim of this study was to evaluate nurse and patient care technician workflow to identify opportunities for providing education. The results informed implementation of a diabetes education program on a tablet computer in the hospital setting within existing nursing workflow with existing staff.

METHODS

We conducted a time and motion study of nurses and patient care technicians on three medical-surgical units of a large urban tertiary care hospital. Five trained observers conducted observations in 2-hour blocks. During each observation, a single observer observed a single nurse or patient care technician and recorded the tasks, locations, and their durations using a Web-based time and motion data collection tool. Percentage of time spent on a task and in a location and mean duration of task and location sessions were calculated. In addition, the number of tasks and locations per hour, number of patient rooms visited per hour, and mean time between visits to a given patient room were determined.

RESULTS

Nurses spent approximately one-third of their time in direct patient care and much of their time (60%) on the unit but not in a patient room. Compared with nurses, patient care technicians spent a significantly greater percentage of time in direct patient care (42%; P=.001). Nurses averaged 16.2 tasks per hour, while patient care technicians averaged 18.2. The mean length of a direct patient care session was 3:42 minutes for nurses and 3:02 minutes for patient care technicians. For nurses, 56% of task durations were 2 minutes or less, and 38% were one minute or less. For patient care technicians, 62% were 2 minutes or less, and 44% were 1 minute or less. Nurses visited 5.3 and patient care technicians 9.4 patient rooms per hour. The mean time between visits to a given room was 37:15 minutes for nurses and 33:28 minutes for patient care technicians.

CONCLUSIONS

The workflow of nurses and patient care technicians, constantly in and out of patient rooms, suggests an opportunity for delivering a tablet to the patient bedside. The average time between visits to a given room is consistent with bringing the tablet to a patient in one visit and retrieving it at the next. However, the relatively short duration of direct patient care sessions could potentially limit the ability of nurses and patient care technicians to spend much time with each patient on instruction in the technology platform or the content.
Capturing Relevant Patient Data in Clinical Encounters Through Integration of an Electronic Patient-Reported Outcome System Into Routine Primary Care in a Boston Community Health Center: Development and Implementation Study (Preprint)
Authors: Loo Stephanie , Grasso Chris , Glushkina Jessica , McReynolds Justin , Lober William , Crane Heidi , Mayer Kenneth H
Published: November 2019

BACKGROUND

Electronic patient-reported outcome (ePRO) systems can improve health outcomes by detecting health issues or risk behaviors that may be missed when relying on provider elicitation.

OBJECTIVE

This study aimed to implement an ePRO system that administers key health questionnaires in an urban community health center in Boston, Massachusetts.

METHODS

An ePRO system that administers key health questionnaires was implemented in an urban community health center in Boston, Massachusetts. The system was integrated with the electronic health record so that medical providers could review and adjudicate patient responses in real-time during the course of the patient visit. This implementation project was accomplished through careful examination of clinical workflows and a graduated rollout process that was mindful of patient and clinical staff time and burden. Patients responded to questionnaires using a tablet at the beginning of their visit.

RESULTS

Our program demonstrates that implementation of an ePRO system in a primary care setting is feasible, allowing for facilitation of patient-provider communication and care. Other community health centers can learn from our model in terms of applying technological innovation to streamline clinical processes and improve patient care.

CONCLUSIONS

Our program demonstrates that implementation of an ePRO system in a primary care setting is feasible, allowing for facilitation of patient-provider communication and care. Other community health centers can learn from our model for application of technological innovation to streamline clinical processes and improve patient care.
Assessing neurosurgical trends in literature and online: a Google Trends, Google Books and PubMed study (Preprint)
Authors: Szmuda Tomasz , Ali Shan , Słoniewski Paweł
Published: November 2019

BACKGROUND

Google Books Ngram Viewer (Ngram) is an open online database of 5 million printed books where the frequency of words occurring in books can be analyzed over time. Google Trends is a tool that allows one to gauge popularity of search terms and topics over time. These tools have not yet been used together to assess the historical and current the trends in neurosurgery.

OBJECTIVE

To assess the neurosurgical trends in literature and online in the past and currently.

METHODS

Ngram, Google Trends and PubMed data were used to analyze the neurosurgical trends from 2004–2008. Next, Google Trends and PubMed data was obtained from 2018 to compare the data. The following keywords were searched on all three platforms: brain tumor, sciatica, neurosurgery, hydrocephalus and concussion.

RESULTS

Each platform had a characteristic interest in each topic. Online Google searches were most concerned with sciatica (62/100 worldwide), the scientific community with neurosurgery (7661 average yearly publications) and book authors wrote most about concussions (0.00013% worldwide Google One Million books). Sciatica held both the least scientific publications (129 average yearly publications) and one of the least mentions in printed books (0.000030% worldwide Google One Million books). The online and PubMed interest levels stayed the same from 2004 to 2018. However, concussion—which held one of the lowest online search interests from 2004 to 2008—had a major increase in 2018 online searches.

CONCLUSIONS

Ngram, Google Trends and PubMed data together provide valuable insights into the health interests among physicians and the public. It is crucial for neurosurgeons to be aware of historical trends as they offer vital insight on the driving factors in medicine today. Physicians can use this understanding to better align public and scientific concerns for the future, provide better patient education and raise awareness on issues that might be overlooked by the public.
Metrics for Outpatient Portal Use Based on Log File Analysis: Algorithm Development (Preprint)
Authors: Di Tosto Gennaro , McAlearney Ann Scheck , Fareed Naleef , Huerta Timothy R
Published: November 2019

BACKGROUND

Web-based outpatient portals help patients engage in the management of their health by allowing them to access their medical information, schedule appointments, track their medications, and communicate with their physicians and care team members. Initial studies have shown that portal adoption positively affects health outcomes; however, early studies typically relied on survey data. Using data from health portal applications, we conducted systematic assessments of patients’ use of an outpatient portal to examine how patients engage with the tool.

OBJECTIVE

This study aimed to document the functionality of an outpatient portal in the context of outpatient care by mining portal usage data and to provide insights into how patients use this tool.

METHODS

Using audit log files from the outpatient portal associated with the electronic health record system implemented at a large multihospital academic medical center, we investigated the behavioral traces of a study population of 2607 patients who used the portal between July 2015 and February 2019. Patient portal use was defined as having an active account and having accessed any portal function more than once during the study time frame.

RESULTS

Through our analysis of audit log file data of the number and type of user interactions, we developed a taxonomy of functions and actions and computed analytic metrics, including frequency and comprehensiveness of use. We additionally documented the computational steps required to diagnose artifactual data and arrive at valid usage metrics. Of the 2607 patients in our sample, 2511 were active users of the patients portal where the median number of sessions was 94 (IQR 207). Function use was comprehensive at the patient level, while each session was instead limited to the use of one specific function. Only 17.45% (78,787/451,762) of the sessions were linked to activities involving more than one portal function.

CONCLUSIONS

In discussing the full methodological choices made in our analysis, we hope to promote the replicability of our study at other institutions and contribute to the establishment of best practices that can facilitate the adoption of behavioral metrics that enable the measurement of patient engagement based on the outpatient portal use.