bluuebunny/crossref_metadata_2025 huggingface dataset:
Adsorption of Arsenate from Aqueous Solution onto Modified Vietnamese Bentonite
Authors: My Linh Nguyen Le , Hoang Van Duc , Duong Tran , Tinh Mai Xuan , Quang Khieu Dinh
Published: April 2019

In this study, pillared layered clays were prepared by modifying Vietnamese bentonite with polymeric Al and Fe. The obtained materials were characteristic of X-ray diffraction analysis, thermal analysis, and nitrogen adsorption/desorption isotherms. The results indicated that hydroxy-aluminum ([Al13O4(OH)24(H2O)12]7+) and poly-hydroxyl-Fe or polyoxo-Fe cations were intercalated into layers of clay, resulting in an increase of d001 values and of the specific surface areas compared with those of initial bentonite. Modified bentonites were employed to adsorb As(V) from aqueous solution. The adsorption of As(V) was strongly dependent on solution pH, and the maximum adsorption of modified bentonites was obtained in the pH 3.0 for Fe-bentonite and the pH 4.0 for Al-bentonite. The equilibrium adsorption study showed that the data were well fit by the Langmuir isotherm model. The maximum monolayer adsorption capacity of As(V) at 30°C derived from the Langmuir equation was 35.71 mg/g for Al-bentonite and 18.98 mg/g for Fe-bentonite. Adsorption kinetics, thermodynamics, and reusability of modified bentonites have been addressed.
Simulation of the Thermal Conditions of Cask with Fuel Assemblies of BN-350 Reactor for Dry Storage
Authors: Koyanbayev Ye. T. , Skakov M. K. , Ganovichev D. A. , Martynenko Ye. A. , Sitnikov A. A.
Published: April 2019

The analysis of the thermal condition of spent FA (fuel assembly) of BN-350 reactor in a six-place cask for dry storage is presented. Simulation of the thermal condition of the cask is conducted with finite elements method using ANSYS software. Calculations of fuel temperature, fuel cladding, and assembly structural elements are the part of the safety analysis for storage of spent FA. In conclusion, the results of the thermal calculations in the cases of filling cask with argon and atmospheric air are given when the thickness of the insulation cask with concrete is 0.5 and 1 m. As a result of the calculated studies, the parameters of SNF (spent nuclear fuel) storage are determined, under which the fuel temperatures will have minimum and maximum values.
A General Review on Longwall Mining-Induced Fractures in Near-Face Regions
Authors: Bai Qingsheng , Tu Shihao
Published: April 2019

It is believed that underground longwall mining usually produces fractures in the surrounding rocks. On the one hand, mining-induced fractures not only degrade the strength of the rock mass but also serve as main channels for fluids (e.g., water and methane). Fractures facilitate the failure of the rock mass and fluid inrush into working spaces. Therefore, mining-induced fractures are significant for the safety evaluation of underground structures and finding feasible solutions. On the other hand, the fractures are also beneficial for methane collection and coal fragmentation, which are essential for the successful operation of longwall top coal caving mining. Therefore, determining the characteristics of induced fractures is significant for underground longwall mining. From a global perspective, longwall mining-induced fractures in the overburden have been well studied, which improves the understanding of the mining pressure and ground control. However, induced fractures near the longwall face, which have more significant effects on mining activities, have not been summarized. The goal of this review paper is to provide a general summary of the current achievements in characterizing mining-induced fractures in near-face regions. The characteristics of mining-induced fractures in the coal wall, chain pillar, immediate roofs and top coal, and floors are reviewed and summarized. Remarks are made on the current progress of, fundamental problems with, and developments in methodologies for characterizing mining-induced fractures using methods such as field observations, small-scale laboratory tests, physical modeling, and numerical modeling. Based on a comprehensive analysis, the advantages and disadvantages of each method are discussed, and the ideal conditions for applying each of these methods are also recommended.
Renal Allograft Rejection: Noninvasive Ultrasound- and MRI-Based Diagnostics
Authors: Jehn Ulrich , Schuette-Nuetgen Katharina , Kentrup Dominik , Hoerr Verena , Reuter Stefan
Published: April 2019

To date, allogeneic kidney transplantation remains the best available therapeutic option for patients with end-stage renal disease regarding overall survival and quality of life. Despite the advancements in immunosuppressive drugs and protocols, episodes of acute allograft rejection, a sterile inflammatory process, continue to endanger allograft survival. Since effective treatment for acute rejection episodes is available, instant diagnosis of this potentially reversible graft injury is imperative. Although histological examination by invasive core needle biopsy of the graft remains the gold standard for the diagnosis of ongoing rejection, it is always associated with the risk of causing substantial graft injury as a result of the biopsy procedure itself. At the same time, biopsies are not immediately feasible for a considerable number of patients taking anticoagulants due to the high risk of complications such as bleeding and uneven distribution of pathological changes within the graft. This can result in the wrong diagnosis due to the small size of the tissue sample taken. Therefore, there is a need for a tool that overcomes these problems by being noninvasive and capable of assessing the whole organ at the same time for specific and fast detection of acute allograft rejection. In this article, we review current state-of-the-art approaches for noninvasive diagnostics of acute renal transplant inflammation, i.e., rejection. We especially focus on nonradiation-based methods using magnetic resonance imaging (MRI) and ultrasound.
First Report of Diabetes Phenotype due to a Loss-of-Function ABCC8 Mutation Previously Known to Cause Congenital Hyperinsulinism
Authors: Koufakis Theocharis , Sertedaki Amalia , Tatsi Elizabeth-Barbara , Trakatelli Christina-Maria , Karras Spyridon N. , Manthou Eleni , Kanaka-Gantenbein Christina , Kotsa Kalliopi
Published: April 2019

Monogenic Diabetes is relatively rare, representing only 1-2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as type 1 diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members. In the present article, we describe a case of a young, male patient who presented with hyperglycemia in the absence of ketosis and following genetic testing; he proved to harbor the loss-of-function p.Arg1353His (c.4058G>A) mutation in the ABCC8 gene, inherited from his mother. This mutation has been previously described in patients with Congenital Hyperinsulinism. Furthermore, different mutations in the ABCC8 gene have been linked with MODY 12, type 2, and gestational diabetes; however, to the best of our knowledge, this is the first report that associates this specific mutation with diabetes phenotype. ABCC8-related diabetes is characterized by remarkable heterogeneity in terms of clinical presentation and therapeutic approach. Early diagnosis and individualized treatment are essential to achieving metabolic targets and avoiding long-term diabetes complications.
Nonlinear Quantum‐Inspired Weighting Structuring Element for Bearing Impulse Response Signal Processing
Authors: Ren Guoquan , Chen Yanlong , Li Chengzhu , Cheng Ziyang
Published: April 2019

In order to solve the disadvantage of conventional structuring element (CSE) where amplitude does not change in accordance with the analyzed signal, the quantum theory is combined and a nonlinear quantum‐inspired weighting structuring element (NQWSE) is proposed. The NQWSE which is utilized to extract the bearing impulse response signal can adjust its amplitude according to the mechanical signal. Firstly, after constructing the multiple quantum bits system for signals, the mapping method which is employed to map the quantum space to the real space is presented and the parameters of the mapping method are set. The nonlinear amplitude probability is calculated based on the stochastic characteristics of the bearing signals, while the dynamic amplitude is calculated based on the local feature of the bearing signals in a subwindow. Then the mathematical formula of NQWSE is derived by incorporating the mathematical expectation into the quantum theory and the mapping method. Finally, the NQWSE is applied to extract the fault information of a failure bearing. The results reveal that NQWSE can extract the bearing impulse response signals exactly.
Monthly Unit Commitment Model and Algorithm with Renewable Energy Generation Considering System Reliability
Authors: Zhu Yongli , Liu Xuechun , Zhai Yujia , Deng Ran
Published: April 2019

With the sustained growth in renewable energy penetration, it is important to incorporate the interval prediction information of the wind and photovoltaic power into the monthly unit commitment model and introduce the system reliable rate as an indicator to measure the system reliability, which make an important contribution to deal with the volatility and randomness of the wind and photovoltaic power and ensure the economy and reliability of the monthly unit commitment. To enhance the practicality of the model and improve the solving ability, the multiobjective function composed by operating cost and reliable rate is transformed into a single‐objective function by using the evaluation function based on geometric weighting method. An adaptive genetic algorithm (AGA) is used to solve the above problem when the prohibiting inbreeding strategy is adopted to replace the mutation operator, avoiding the hybridization between close relatives and containing the diversity of the population. Finally, the testing systems verify the validity and accuracy of the proposed model and algorithm.
A Rare Case of Grey Zone Lymphoma Successfully Treated with Brentuximab Vedotin and R-CHP Chemotherapy
Authors: Mallipudi Rajiv M. , Alquran Lance , Shenoy Vishnu A. , Leslie Lori A. , Conti John A.
Published: April 2019

Introduction. The diagnosis of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin’s lymphoma (cHL), also referred to as grey zone lymphoma (GZL), is a challenging diagnosis. There are no standardized guidelines; however, evidence strongly suggests that DLBCL-based regimens are effective in the treatment of GZL. Brentuximab vedotin (BV) is an anti-CD30 antibody drug conjugate that has established efficacy in relapsed/refractory Hodgkin and some T-cell lymphomas. There is some evidence that BV has a positive response in non-Hodgkin lymphoma (NHL) with a wide range of CD30 expressions—including GZL.Case. We present a case of a patient initially diagnosed with cHL who underwent repeat biopsy which was revealed to be GZL. Based on PET scanning and immunohistochemical studies, she was classified as a stage IIIA CD20+/CD30+ GZL patient. Given her strong CD30 expression, she underwent 6 cycles of R-BV-CHP (rituximab, brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone) chemotherapy and achieved complete response (CR) both clinically and radiographically.Discussion. Given the rarity of GZL, this case illustrates the immense challenges in making the diagnosis, discusses the current treatment options, and suggests that BV may be a viable therapeutic candidate in the treatment of GZL.
Comparative Quantitative Study on Phytochemical Contents and Antioxidant Activities of Capsicum annuum L. and Capsicum frutescens L.
Authors: Olatunji Tomi Lois , Afolayan Anthony Jide
Published: April 2019

The variabilities in the phytochemical contents and antioxidant activities of four varieties of two closely related cultivated Capsicum species, C. annuum and C. frutescens, were examined as an additional tool for establishing their phylogenetic relatedness and for breeding purposes. The methodology involved the use of ethanolic and aqueous extractions for the determination of the phytochemical and antioxidant properties. The phytochemical contents including total flavonoid, total phenol, and proanthocyanidins were evaluated spectrophotometrically while the antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), nitric oxide (NO), and phosphomolybdenum assays. To point out the relationship among the varieties, a dendrogram based on the antioxidative phytochemical contents was constructed using the unweighted pair group method with arithmetic mean (UPMGA) cluster analysis. In all, aqueous extracts gave higher yield while ethanolic extracts showed higher phytochemical content across the varieties. Significant variations were observed among the varieties in relation to their phytochemical constituents and antioxidant activities. Dendrogram obtained from multivariate analysis distinguished the two Capsicum species. The first cluster contained only C. frutescens var. baccatum while the second cluster contained the three varieties of C. annuum species in subclusters, signifying the close genetic affinity among the three varieties. It also revealed that the four varieties are of a common progenitor. Information from this study gives additional evidence of chemotaxonomic significance and baseline data for effective selection of suitable parental genotypes in breeding for nutritional and pharmacological purposes.
Price Linkage Rumors in the Stock Market and Investor Risk Contagion on Bilayer‐Coupled Networks
Authors: Dong Yue , Wang Jiepeng , Chen Tingqiang
Published: April 2019

Investor heterogeneities include investor risk preference, investor risk cognitive level, information value, and investor influence. From the perspective of the stock price linkage, this article constructs an SCIR contagion model of investor risk on a single‐layer network. It digs out the investor risk caused by rumors in the stock market under the stock price linkage and its contagion mechanism. The function and influence of different mechanism probabilities and investor heterogeneities on the effects of risk contagion in the stock market are explored through computer simulation. Based on the SCIR contagion model of investor risk on single‐layer network, we construct an SCI1I2R contagion model of investor risk on bilayer‐coupled networks. Initially, the evolution mechanisms of investor risk contagion in the stock market are compared in single‐layer and bilayer‐coupled networks. Thereafter, the evolution characteristics and rules of investor risk contagion under different connection modes and heterogeneous mechanism probabilities are compared on bilayer‐coupled networks. The results corroborate the following. (1) In the SCIR contagion model of investor risk on a single‐layer network, immune failure probability and immune probability have the “global effect”. (2) Investor heterogeneities both have “global effect” and “local effect” on investor risk contagion. (3) Compared with the investor risk contagion on a single‐layer network, bilayer‐coupled networks can expand the investor risk contagion and have a “global enhancement” effect. (4) Among the three interlayer connection modes of the SCI1I2R model of investor risk contagion on bilayer‐coupled networks, the assortative link has the effect of “local enhancement”, while the disassortative link has the effect of “local inhibition”. (5) In the SCI1I2R model of investor risk contagion on bilayer‐coupled networks, heterogeneous mechanism probabilities have “global effect” and “local effect”. The research conclusion provides a theoretical basis for regulators to prevent financial risks from spreading among different investors, which is of high theoretical value and practical significance.
A Rare Case of Extramedullary Relapse of Multiple Myeloma Causing Bowel Obstruction
Authors: Bhardwaj Prarthna V. , Khanna Shrinkhala , Jawad Majd D. , Ali Syed S.
Published: April 2019

Extramedullary myeloma, defined by presence of plasma cells outside the bone marrow, is a rare entity accounting for about 3–9% of all cases. It usually is aggressive with a median survival of <6 months. It is also associated with adverse prognostic factors including 17p deletions and high-risk gene profiles. While common extramedullary sites include bones, there have been several case reports of hematogenous extramedullary myeloma to the liver, lungs, pancreas, breast, skin, and soft tissues. Extramedullary myeloma to the mesentery is a rare entity with only a handful of cases reported. We present a case of 69-year-old man presenting with relapse of multiple myeloma to the mesentery, resulting in bowel obstruction to highlight the various presentations of myeloma.
Threat Assessment for Android Environment with Connectivity to IoT Devices from the Perspective of Situational Awareness
Authors: Park Mookyu , Han Jaehyeok , Oh Haengrok , Lee Kyungho
Published: April 2019

As smartphones such as mobile devices become popular, malicious attackers are choosing them as targets. The risk of attack is steadily increasing as most people store various personal information such as messages, contacts, and financial information on their smartphones. Particularly, the vulnerabilities of the installed operating systems (e.g., Android, iOS, etc.) are trading at a high price in the black market. In addition, the development of the Internet of Things (IoT) technology has created a hyperconnected society in which various devices are connected to one network. Therefore, the safety of the smartphone is becoming an important factor to remotely control these technologies. A typical attack method that threatens the security of such a smartphone is a method of inducing installation of a malicious application. However, most studies focus on the detection of malicious applications. This study suggests a method to evaluate threats to be installed in the Android OS environment in conjunction with machine learning algorithms. In addition, we present future direction from the cyber threat intelligence perspective and situational awareness, which are the recent issues.
Coelomic Fluid of Lumbricus rubellus Synergistically Enhances Cytotoxic Effect of 5-Fluorouracil through Modulation of Focal Adhesion Kinase and p21 in HT-29 Cancer Cell Line
Authors: Endharti Agustina Tri , Purnamasari Yeni , Primasari Renata , Poeranto Sri , Permana Sofy
Published: April 2019

Coelomic fluid of Lumbricus rubellus (CFL) has attracted interest due to its pharmacological properties, including antitumor effect. Furthermore, it is necessary to evaluate the response to treatment with new cancer therapeutic agents. This study aims to investigate whether the combination of CFL and 5-fluorouracil could reduce FAK protein level and iCa2+ and enhance p21 level. Furthermore, it is necessary to evaluate the response to treatment with new cancer therapeutic agents. After 24 hours of treatment, it was necessary to assess the percentage of apoptosis, FAK, and p21 protein expression by flow cytometry. iCa2+ concentration was measured using immunofluorescence. The combination therapy of CFL with 5-fluorouracil potently suppressed six treatment groups were included in this study. HT-29 cell lines were cultured and divided into six groups: group 1 was treated with vehicle (negative control), groups 2-5 were treated with 5-fluorouracil, groups 3-5 were treated with either CFL 5, 10, or 20 µg/ml immediately after 5-fluorouracil, and group 6 was treated with CFL 20 µg/ml, the progression of colorectal cancer. Combination of CFL and 5-fluorouracil significantly decreased FAK expression (p<0.05), iCa2+ (p<0.05), and increased p21 expression (p<0.05) in HT-29 cells. Our results suggest that CFL has an anticancer potential in colorectal cancer when combined with 5-fluorouracil.
Modified Adomian Decomposition Method to Solve Generalized Emden–Fowler Systems for Singular IVP
Authors: Abdullah Alderremy Aisha , Elzaki Tarig M. , Chamekh Mourad
Published: April 2019

An adeptness modified Adomian decomposition method (MADM) is proposed to solve a generalized system of Emden–Fowler type. By a few examples, it is shown that this method can overcome a singular initial value problem.
Nutritional Status of Children Aged 12 to 36 Months in a Rural District of Hungyen Province, Vietnam
Authors: Chuc Dang Van , Hung Nguyen Xuan , Trang Vuong Thi , Linh Dang Viet , Khue Pham Minh
Published: April 2019

Objective. To evaluate the nutritional status of children from 12 to 36 months of age in Kimdong, a rural district in Hungyen Province, Northern Vietnam, in 2017. Subjects and Methods. A cross-sectional study was carried out on 327 children aged 12-36 months. The data collected included anthropometric measurement, serum hemoglobin (Hb), and vitamin D concentration. Blood analysis was done at the Center Laboratory of Hungyen Obstetrics and Pediatrics Hospital. Underweight, stunted, and wasted children were classified based on z-scores cut-off less than -2 SD of weight for age (WAZ), height for age (HAZ), and weight for height (WHZ), respectively. Overweight and obese children were defined if WHZ was more than + 2SD. Anemic child was applied when Hb concentration was less than 110 g/L while vitamin D deficiency was termed for level less than 20 ng/L. Results. The prevalence of underweight, stunted, wasted, and overweight/obese children was 7.6%, 23.5%, 6.7%, and 1.2%, respectively. The prevalence of anemia and vitamin D deficiency was 33.3% and 47.7%, respectively. Malnutrition, anemia, and vitamin D deficiency were not statistically different by sex. Malnutrition and vitamin D deficiency were not statistically different by age group but anemia by age groups was significantly different. Conclusions. Stunting is still prevalent in children aged 12-36 months in Kimdong. Moreover, anemia and vitamin D deficiency also affected children in this area. Some interventions should be conducted to improve the nutritional status of children in Kimdong district.
Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
Authors: Mariotti Benedetta , Meconi Federico , Palmieri Raffaele , De Bellis Eleonora , Lavorgna Serena , Ottone Tiziana , Martini Vincenza , Lo-Coco Francesco , Cicconi Laura
Published: April 2019

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.
Study on Centroid Type‐Reduction of Interval Type‐2 Fuzzy Logic Systems Based on Noniterative Algorithms
Authors: Chen Yang
Published: April 2019

Interval type‐2 fuzzy logic systems have favorable abilities to cope with uncertainties in many applications. While the block type‐reduction under the guidance of inference plays the central role in the systems, Karnik‐Mendel (KM) iterative algorithms are standard algorithms to perform the type‐reduction; however, the high computational cost of type‐reduction process may hinder them from real applications. The comparison between the KM algorithms and other alternative algorithms is still an open problem. This paper introduces the related theory of interval type‐2 fuzzy sets and discusses the blocks of fuzzy reasoning, type‐reduction, and defuzzification of interval type‐2 fuzzy logic systems by combining the Nagar‐Bardini (NB) and Nie‐Tan (NT) noniterative algorithms for solving the centroids of output interval type‐2 fuzzy sets. Moreover, the continuous version of NT (CNT) algorithms is proved to be accurate algorithms for performing the type‐reduction. Four computer simulation examples are provided to illustrate and analyze the performances of two kinds of noniterative algorithms. The NB and NT algorithms are superior to the KM algorithms on both calculation accuracy and time, which afford the potential application value for designer and adopters of type‐2 fuzzy logic systems.
Reconstructive Challenges of Proximal Ulnar Bone Tumors: Our Experience with Biological Osteoarticular Reconstruction Using Extracorporeal Irradiation and Reimplantation
Authors: Gundavda Manit K. , Agarwal Manish G. , Reddy Rajeev
Published: April 2019

Introduction. Limb salvage surgery following proximal ulna resection poses a challenge in reconstruction of the complex elbow anatomy. Various reconstruction methods described offer inadequate restoration of function and stability. Following resection of proximal ulna tumors, we aimed to restore the joint using the resected osteochondral segment of proximal ulna treated with extracorporeal irradiation and reimplantation. Questions/Purposes. (1) Does irradiated osteoarticular autograft reconstruction for proximal ulna allow anatomical joint restoration and what are the oncological and functional outcomes? (2) Is there evidence of graft-related complications or osteoarthritis at a minimum of 2 years follow-up with irradiated osteoarticular autografts for the proximal ulna? (3) How does our method of reconstruction fare as compared to reported reconstruction options in the literature? Materials and Methods. 3 patients with primary bone tumors involving the proximal ulna underwent limb salvage surgery with en bloc resection and reconstruction using the resected bone after treating it with extracorporeal irradiation of 50 Gy. Minimum follow-up of 2 years was considered for assessment of final outcomes. Radiographs were assessed for bony recurrence, union across osteotomy junction, and signs of joint arthritis. Functional outcome measures included range of movement, muscle power testing, and functional and disability scores. Results. 2 complete and 1 partial olecranon involving proximal ulnar resections were performed for three cases of Ewing’s sarcoma in 2 males and 1 female. Follow-up ranged from 28 to 42 months, and all patients continue to remain disease free. All 3 patients have achieved full range of flexion-extension and pronosupination movement in comparison to the contralateral side. Muscle power for flexion and extension was 5/5. MSTS score: 100% (30/30); MEPS score: 100; and DASH score: zero were achieved for all patients. Union across osteotomy junctions at median follow-up of 8 months without need for intervention/bone grafting was achieved. No complications related to joint laxity/subluxation, infection, graft fracture, or implant failure was noted. None of the patients have clinical or radiological signs of joint arthritis across the irradiated articulation. Conclusion. Biological restoration of elbow anatomy using osteoarticular irradiated graft for proximal ulna reconstruction offers great joint stability and functional outcomes. Although the potential risks of infection and graft failure need to be considered, reconstruction with the size-matched radiated autograft eliminates donor site morbidity, offers a low-cost alternative to endoprosthesis, and provides outcomes superior to any other methods of reconstruction as analyzed from the literature.
Analytic Solution for Systems of Two-Dimensional Time Conformable Fractional PDEs by Using CFRDTM
Authors: Chaouk Abir , Jneid Maher
Published: April 2019

In this study we use the conformable fractional reduced differential transform (CFRDTM) method to compute solutions for systems of nonlinear conformable fractional PDEs. The proposed method yields a numerical approximate solution in the form of an infinite series that converges to a closed form solution, which is in many cases the exact solution. We inspect its efficiency in solving systems of CFPDEs by working on four different nonlinear systems. The results show that CFRDTM gave similar solutions to exact solutions, confirming its proficiency as a competent technique for solving CFPDEs systems. It required very little computational work and hence consumed much less time compared to other numerical methods.
On Some Conditions for Strong Law of Large Numbers for Weighted Sums of END Random Variables under Sublinear Expectations
Authors: Ma Xiaochen , Wu Qunying
Published: April 2019

In this article, we research some conditions for strong law of large numbers (SLLNs) for weighted sums of extended negatively dependent (END) random variables under sublinear expectation space. Our consequences contain the Kolmogorov strong law of large numbers and the Marcinkiewicz strong law of large numbers for weighted sums of extended negatively dependent random variables. Furthermore, our results extend strong law of large numbers for some sequences of random variables from the traditional probability space to the sublinear expectation space context.
Farmers’ Perceptions of Mexican Bean Weevil, Zabrotes subfasciatus (Boheman), and Pest Management Practices in Southern Ethiopia
Authors: Mesele Tariku , Dibaba Kumela , Mendesil Esayas
Published: April 2019

The common bean, Phaseolus vulgaris L., is one of the most important sources of protein in Ethiopia and other developing countries. However, the Mexican bean weevil, Zabrotes subfasciatus (Boheman), is a major constraint of stored common bean that causes qualitative and quantitative losses. This study was conducted to assess farmers’ knowledge and perceptions of Mexican bean weevil, to examine farmers’ pest management practices, and to identify challenges of pest management practices to develop integrated pest management (IPM) strategies. A survey of 148 smallholder common bean farmers was conducted at Mareka and Loma districts in southern Ethiopia. The majority (75%) of the farmers stored common bean in polypropylene bags while less than 10% of the farmers stored beans in ‘Diya’ (a traditional storage structure). Most (60.8%) farmers stored their beans in seed (threshed) form, and the majority (63.5%) of them stored their beans for 3-5 months. The majority of the farmers had knowledge about the Mexican bean weevil; they could identify damaged seeds based on the ‘holes’ on the seed (72.3%) and circular ‘windows’ on the seed (20.0%). About 45% of the farmers mentioned the high amount of loss at the time of storage. In addition, most farmers (53.4%) estimated 26-50% loss in storage. Most farmers reported the use of pesticidal plants for control of Mexican bean weevil, while only a few farmers reported they had applied insecticide in their store. Education level and family size had a positive and statistically significant impact on the use of pesticidal plants for the control of Mexican bean weevil. Furthermore, education level also influences the use of chemical insecticide. Results highlighted the need to use improved storage technology and to train farmers in postharvest handling practices as a component to develop IPM approach in order to minimize losses occurring along the value chains of the common bean.
On Novel Nonhomogeneous Multivariable Grey Forecasting Model NHMGM
Authors: Wang Haixia , Wang Peiguang , Şenel M. Tamer , Li Tongxing
Published: April 2019

A novel nonhomogeneous multivariable grey forecasting model termed NHMGM(1, m, kp, c) is proposed in this paper for use in nonhomogeneous multivariable exponential data sequences. The NHMGM(1, m, kp, c) model is able to reflect the nonlinear relation of the data sequences in the system, and it is proved that many classic grey forecasting models can be derived from NHMGM(1, m, kp, c) model. Parameters of the novel model are obtained by using least square method, and the time response function is given. A numerical example is presented to show the effectiveness of the proposed model, six different grey forecasting models are built for modeling, and two popular accuracy criteria (ARPE and MAPE) are adopted to test the reliability of the novel model. The example demonstrates that NHMGM‐2 model provides favorable performance compared with the other five grey models. Additionally, the multiplication transformation properties of NHMGM(1, m, kp, c) are systematically analysed, which establish a theoretical foundation for further applications of the model.
Continuous Surgical Decompression for Solitary Bone Cyst of the Jaw in a Teenage Patient
Authors: Brunet-Llobet Lluís , Lahor-Soler Eduard , Mashala Elias Isaack , Miranda-Rius Jaume
Published: April 2019

Background. A solitary bone cyst or simple bone cyst is a nonneoplastic osseous lesion, with no epithelial lining, also considered as a pseudocyst. These lesions, with an intact bony wall and fluid-filled, are frequently discovered by chance in radiological studies. The etiopathogenesis has not been studied in depth, and the management remains controversial. Case Presentation. We present a clinical case of a 15-year-old boy who underwent an orthopantomography to assess the development and position of the third molars during a routine postorthodontic check-up. By chance, the X-ray identified an asymptomatic radiolucent image in the left jaw, measuring 12.0 mm×17.8 mm and compatible with a solitary bone cyst involving teeth 35 and 36. We describe our technique for performing minimally invasive decompression of the lesion using a microperforated catheter. We describe the entire course of the follow-up, both clinical and radiological, until complete cure. Conclusions. This straightforward continuous decompression technique poses no problems for the patient, has a low risk of sequelae, and is clearly cost-effective. In view of the highly satisfactory evolution, whenever possible, we favor this minimally invasive technique for the treatment of solitary bone cysts in the jaw.
Designing a High-Precision AC Current Source to Measure the nm-Scale Displacements in Mechanical Systems
Authors: Rasolofondraibe Lanto , Pottier Bernard , Chiementin Xavier
Published: April 2019

Measuring the dynamics of a continuously moving target, at the nanoscale level, such as of a bearing raceway or any other vibrating element, requires a contactless measurement. A mission that can be easily carried out by a capacitive probe. The current flowing through the sensor has to remain constant regardless of the changes in the sensors’ output impedance. In this manner, the voltage across the probe is proportional to the distance between the probe and the target. However, the high impedance of the probe cannot be disregarded in comparison to the output impedance of the Howland source. To overcome this problem, we designed a voltage-controlled AC current source (VCCS). The new design consists of implementing two nested loops and uses two cascaded controllers, a fast but imprecise internal control loop tuned by a slow but precise outer control loop in order to obtain a high-precision AC output current. The performance of this device has been compared with the improved quad op-amp current source (IQOA). The results obtained during the numerical validation confirm the relevance of this device.
An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
Authors: Manière Louis , Domenger Camille , Camara Boubou , Giovannini Diane , Malvezzi Paolo , Rostaing Lionel
Published: April 2019

We herein describe the first case of thrombotic microangiopathy (TMA) which was related to Shiga toxin producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) after lung transplantation. His maintenance immunosuppression relied on tacrolimus plus mycophenolic acid. TMA was treated with plasma exchanges (PE) (fresh frozen plasma substitution). After five days of PE, platelets count and lactate dehydrogenase level normalized, whereas hemoglobin continued to gradually decrease and no improvement in kidney function was observed. After seven PE sessions, all TMA biological signs resolved. However, kidney function did not improve, and the patient still required chronic dialysis.
Investigation of the Load‐Sharing Theory of the RC Pipes Rehabilitated with Slip Liners
Authors: Li Bai-jian , Zhu Liang-sheng , Fu Xin-sha
Published: April 2019

Slip‐lining is a preferred rehabilitation approach in the departments of transportation in China. Although the method is the most common rehabilitation technique, few research studies have been conducted on the mechanical behavior of a rehabilitated reinforced concrete pipe (RCP). A series of experiments were conducted on RCPs rehabilitated with a corrugated steel pipe (CSP), a steel pipe, a high‐density polyethylene (HDPE) pipe, and a shape steel bracket. The RCP rehabilitated with the CSP showed an increase in both the load‐carrying capacity (3.46 times greater than the RCP) and the stiffness (5.35 times greater than the RCP). The RCP rehabilitated with the steel pipe, HDPE pipe, and steel bracket exhibited an increase in the load‐carrying capacity (1.23, 1.50, and 1.31 times greater than the RCP, respectively), and the stiffness of these three pipes was not markedly changed. The slip‐lined pipe acts as a “pipe within a pipe” system. A “load‐sharing” theory was proposed in this study and provides estimates of the load‐carrying capacity of the slip‐lined pipes.
The Effect of Concrete Footing Shape in Differential Settlement: A Seismic Design
Authors: Namdar Abdoullah , Dong Yun , Deyu Yin
Published: April 2019

This paper presents the numerical results of concrete footing‐soil foundation seismic interaction mechanism. The concrete footing has been made with two different shapes, but with the equal volume of concrete material. The concrete footing‐soil foundation has been analyzed using nonlinear finite elements, with the fixed‐base state. The simulated near‐fault ground motions have been applied to the concrete footing‐soil foundation. The problem has been formulated based on the settlement controlled analysis. The local geotechnical conditions of all configurations have been analyzed. The numerical analysis results indicate that the shape of a concrete footing alters seismic response, revises inertial interaction, enhances damping ratio, improves load carry capacity, modifies cyclic differential settlement, revises failure patterns, minimizes nonlinear deformation, and changes cyclic strain energy dissipation. The novelty of this research work is the strain energy has more been dissipated with artistic concrete footing design.
Fasting Whole-Body Energy Homeostasis and Hepatic Energy Metabolism in Nondiabetic Humans with Fatty Liver
Authors: Lattuada Guido , Radaelli Maria Grazia , De Cobelli Francesco , Esposito Antonio , Manzoni Giuseppina , Perra Silvia , Del Maschio Alessandro , Castoldi Giovanna , Perseghin Gianluca
Published: April 2019

Background. Fatty liver is believed to be sustained by a higher than normal adipose-derived NEFA flux to the liver. Also, hepatic energy metabolism may be a rate-limiting step of intrahepatic fat (IHF) accumulation. Aims. To assess whole-body energy metabolism and hepatic high-energy phosphates (HEPs) in individuals with fatty liver. Methods. We studied 22 individuals with fatty liver and 22 control individuals matched for anthropometric features by means of (1) hepatic 1H-magnetic resonance spectroscopy (MRS) to measure the IHF content, (2) hepatic 31P-MRS to assess the relative content of HEPs (phosphomonoesters, phosphodiesters, inorganic phosphorus, and ATP), and (3) indirect calorimetry to assess whole-body resting energy expenditure and substrate oxidation. Results. Patients with newly diagnosed fatty liver and controls were not different for anthropometric parameters. Based on HOMA2%-S, individuals with fatty liver were more insulin resistant than controls. Resting energy expenditure and the pattern of substrate oxidation were not different between groups. Relative content of HEPs was not different between groups; in particular, the Pi/γ-ATP ratio, the most important signals in terms of monitoring energy homeostasis, was not different even if it was associated with indirect calorimetry-derived parameters of oxidative substrate disposal. Conclusions. These data demonstrate that fasting whole-body energy metabolism and the relative content of HEPs in nondiabetic patients with fatty liver are not different than those in controls when they are matched for anthropometric features.
Immunonutrition for Preterm Infants
Authors: Walsh Verena , McGuire William
Published: April 2019

Care and outcomes for very preterm infants continue to improve, but important causes of mortality and acute and long-term morbidity associated with prolonged hospitalisation remain. Necrotising enterocolitis (NEC) and late-onset infection have emerged as the major causes of death beyond the early neonatal period and of neurodisability in very preterm infants. Although the pathogenesis of these conditions is incompletely understood, it appears to be related to the content and mode of delivery of the enteral diet, particularly the impact of immunonutrients from human breast milk on the microbial and metabolic balance within the immature intestine. Evidence exists to support investment in measures to help mothers to express breast milk as the primary source of nutrition for their very preterm infants. In the absence of maternal milk, pasteurised donor breast milk provides protection against NEC, but its nutritive adequacy is not clear and its cost-effectiveness is uncertain. Supplementation with individual immunonutrients, including immunoglobulins and lactoferrin, has not been shown to be effective in preventing NEC or infection in randomised controlled trials. The evidence base for prebiotics and probiotics is stronger, but concerns exist about the choice, safety and availability of formulations. Other strategies – including avoidance of drugs such as gastric acid suppressants that compromise innate immunity, as well as evidence-based progressive feeding strategies that reduce exposure to invasive interventions – are emerging as key components of care packages to reduce the burden of NEC, infection and associated growth and developmental faltering for very preterm infants.
Bronchopulmonary Dysplasia: 50 Years after the Original Description
Authors: Bancalari Eduardo , Jain Deepak
Published: April 2019

Bronchopulmonary dysplasia (BPD) is one of the few diseases in neonatal medicine that has continued to evolve since its first description about 50 years ago. Over these years, advancements in neonatal medicine such as antenatal steroids and exogenous surfactant therapy have significantly reduced neonatal mortality and lowered the limits of viability for preterm infants. Although the incidence of BPD continues to be high, especially in extremely low birth weight infants, the clinical picture has evolved into a milder disease with low mortality or significant morbidities. This new BPD is the result of complex interactions between altered alveolar and vascular development, injury by ante- and postnatal pathogenic factors, and reparative processes in the lung. There has been significant progress in our understanding of risk factors for BPD, but challenges persist in its definition, and in finding effective preventive strategies. There are promising developments with newer preventive interventions such as mesenchymal stem cells, exosomes, immunomodulators, and growth factors, but they are still in preclinical stage. The future challenges include finding ways to define BPD based on the severity of lung pathology, which can better predict long-term outcomes, development of early predictors of lung disease, and finding innovative and evidence-based preventive and management strategies.
Extracorporeal Blood Purification Therapies for Sepsis
Authors: Monard Céline , Rimmelé Thomas , Ronco Claudio
Published: April 2019

Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at controlling the associated dysregulation of the immune system, which is known to induce organ dysfunctions. Different therapies have been developed to address certain steps of the immune dysregulation. Most of the available blood purification devices focus on a single target, such as the endotoxin that triggers the immune cascade, or the cytokine storm that causes organ damages. However, the highly adsorptive membrane named oXiris® is a unique 4-in-1 device that combines cytokine and endotoxin removal properties, renal replacement function, and antithrombogenic properties. More recently, promising treatments that focus on the pathogen itself or the immune cells have been developed and are currently under investigation. In this review, we aim to summarize, according to their target, the different extracorporeal blood purification techniques that are already available for use. We will also briefly introduce the most recent techniques that are still under development. Because of its unique ability to remove both endotoxins and cytokines, we will particularly discuss the highly adsorptive preheparinized oXiris® membrane. We will present its properties, advantages, pitfalls, as well as therapeutic perspectives based on experimental and clinical data. Video Journal Club “Cappuccino with Claudio Ronco” at  https://www.karger.com/Journal/ArticleNews/223997?sponsor=52
Epigenetic Regulation of Vascular Diseases
Authors: Zarzour Abdalrahman , Kim Ha Won , Weintraub Neal L.
Published: April 2019

Epigenetic regulatory mechanisms, encompassing diverse molecular processes including DNA methylation, histone post-translational modifications, and noncoding RNAs, are essential to numerous processes such as cell differentiation, growth and development, environmental adaptation, aging, and disease states. In many cases, epigenetic changes occur in response to environmental cues and lifestyle factors, resulting in persistent changes in gene expression that affect vascular disease risk during the lifetime of the individual. Biological aging—a powerful cardiovascular risk factor—is partly genetically determined yet strongly influenced by traditional risk factors, reflecting epigenetic modulation. Quantification of specific DNA methylation patterns may serve as an accurate predictor of biological age—a concept known as the epigenetic clock, which could help to refine cardiovascular risk assessment. Epigenetic reprogramming of monocytes rewires cellular immune signaling and induces a metabolic shift toward aerobic glycolysis, thereby increasing innate immune responses. This form of trained epigenetic memory can be maladaptive, thus augmenting vascular inflammation. Somatic mutations in epigenetic regulatory enzymes lead to clonal hematopoiesis of indeterminate potential, a precursor of hematologic malignancies and a recently recognized cardiovascular risk factor; moreover, epigenetic regulators are increasingly being targeted in cancer therapeutics. Thus, understanding epigenetic regulatory mechanisms lies at the intersection between cancer and cardiovascular disease and is of paramount importance to the burgeoning field of cardio-oncology (Graphic Abstract).