bluuebunny/crossref_metadata_2025 huggingface dataset:
İçme ve Kullanma Suyu Örneklerinin Mikrobiyolojik Kalitesinin Escherichia coli O157:H7 Serotipi Yönünden Araştırılması: Sivas İli Örneği
Authors: ASLAN Rukiye , SÜMER Zeynep
Published: December 2021

Bu çalışma Sivas ili içme ve kullanma sularının koliform grubu Escherichia coli bakterisi O157:H7 serotipi yönününden incelenmesi amacıyla yapılmıştır. Bu amaçla Sivas ili ve ilçelerindeki farklı kaynaklardan 200 adet içme ve kullanma suyu örneği “Su Kirliliği Kontrolü Yönetmeliği (SKKY) Numune Alma ve Analiz Metodları Tebliği” ve “İnsani Tüketim Amaçlı Sular Hakkında Yönetmelik (İTASHY)” standartları referans alınarak toplanmış ve su örneklerinin analizi “TS EN ISO 9308-1 Escherichia coli ve Koliform Bakterilerin Tespiti ve Sayımı: Membran Filtrasyon Yöntemi” referans alınarak çalışılmıştır. Analiz sonrası üreme gösteren koliform ve fekal koliform bakterilerle E. coli bakterisinin doğrulanması amacıyla biyokimyasal testler uygulanmıştır. E. coli O157:H7 serotipi tespiti için SMAC (Sorbitol MacConkey) Agar ve Escherichia coli O157:H7 lateks aglütinasyon kiti kullanılmıştır. İçme ve kullanma suyu örneklerinde %40 koliform bakteri ve %33 E. coli bakterisi tespit edilmiştir. SMAC agardaki kültür sonuçlarına göre, örneklerden 3 tanesi E. coli O157:H7 açısından şüpheli bulunmuş ancak test tekrarları sonucunda su örneklerinde E. coli O157:H7 serotipine rastlanmamıştır. İncelenen içme ve kullanma suyu örneklerinde E. coli bakterisinin O157:H7 serotipine rastlanmasa da, fekal kontaminasyon göstergesi olan koliform bakterilerin ve E. coli bakterisinin bulunmasının sulardaki mikrobiyolojik kirlenme kaynaklı enfeksiyonlara yol açabileceği, bu durumun halk sağlığı açısından olası risk oluşturabileceği, bu amaçla kullanılacak suların tüketilmeden önce yeterli düzeyde dezenfekte edilmesi gerektiği ve dezenfeksiyonun etkinliğinin kontrol edilmesi gerektiği görüşlerine ulaşılmıştır. İçme ve kullanma sularının mikrobiyolojik kalitesinin devamı adına toplumun her kesiminin bilinçlendirilmesi ve su hijyenin sağlanması adına her bireyin etkin rol alması gerektiği düşünülmektedir.
PENGEMBANGAN APLIKASI TELEGRAM PADA KEGIATAN PRAMUKA DI MASA PANDEMI COVID-19
Authors: SHODIQ WAKHIDIN , FAUZI FAUZI
Published: December 2021

This research uses development procedures that result in product design in the form of IT-based learning media development using the Telegram Application. This product researchers developed using research steps from Borg and Gall and THE ASSURE Model. The product developed in this study is an IT-based learning medium using the Telegram Application. With time constraints, researchers limit the steps of development procedures to only 6 (six) steps, namely (1) potential and problems, (2) data collection, (3) product design, (4) validation, (5) design revision, and (6) trials. The purpose of this research is to find out the effectiveness of IT-based learning media in the Telegram Application used in scouting education activities at Ambalan Bhira Sma Negeri 3 Purwokerto during the Covid-19 pandemic.

ABSTRAK Penelitian ini menggunakan prosedur pengembangan yang menghasilkan desain produk berupa pengembangan media pembelajaran berbasis IT dengan menggunakan Aplikasi Telegram. Produk ini peneliti kembangkan dengan menggunakan langkah-langkah penelitian dari Borg and Gall dan Model ASSURE. Produk yang dikembangkan dalam penelitian ini yaitu media pembelajaran berbasis IT menggunakan Aplikasi Telegram. Dengan adanya keterbatasan waktu, maka  peneliti membatasi langkah-langkah prosedur pengembangan hanya pada 6 (enam) langkah, yaitu (1) potensi dan masalah, (2) pengumpulan data, (3) desain produk, (4) validasi, (5) revisi desain, dan (6) uji coba. Tujuan penelitian kali ini untuk mengetahui efektifitas media pembelajaran berbasis IT pada Aplikasi Telegram yang digunakan dalam kegiatan Lajutin Pendidikan Kepramukaan di Ambalan Bhira SMA Negeri 3 Purwokerto pada masa pandemi Covid-19.
Assessment of potential beach erosion risk and impact of coastal zone development: a case study on Bongpo–Cheonjin Beach
Authors: Lim Changbin , Kim Tae Kon , Lee Sahong , Yeon Yoon Jeong , Lee Jung Lyul
Published: December 2021

Abstract. In many parts, coastal erosion is severe due to human-induced coastal zone
development and storm impacts, in addition to climate change. In this study, the beach erosion risk was defined, followed by a quantitative assessment of potential beach erosion risk based on three components associated with the watershed, coastal zone development, and episodic storms. On an embayed beach, the background erosion due to development in the watershed affects sediment supply from rivers to the beach, while alongshore redistribution of sediment transport caused by construction of a harbor induces shoreline reshaping, for which the parabolic-type equilibrium bay shape model is adopted. To evaluate beach erosion during storms, the return period (frequency) of a storm occurrence was evaluated from long-term beach survey data conducted four times per year. Beach erosion risk was defined, and assessment was carried out for each component, from which the results were combined to construct a combined potential erosion risk curve to be used in the environmental impact assessment. Finally, the proposed method was applied to Bongpo–Cheonjin Beach in Gangwon-do, South Korea, with the support of a series of aerial photographs taken from 1972 to 2017 and beach survey data obtained from the period commencing in 2010. The satisfactory outcomes derived from this study are expected to benefit eroding beaches elsewhere.
Sedimentary basins of the eastern Asia Arctic zone: new details on their structure revealed by decompensative gravity anomalies
Authors: Sidorov Roman V. , Kaban Mikhail K. , Soloviev Anatoly A. , Petrunin Alexei G. , Gvishiani Alexei D. , Oshchenko Alexei A. , Popov Anton B. , Krasnoperov Roman I.
Published: December 2021

Abstract. In the present study, the structure of sedimentary basins in the eastern Asia
Arctic zone is analysed by employing the approach based on decompensative
gravity anomalies. Two obtained models, differing in their initial
conditions, provide thickness and density of sediments in the study area.
They demonstrate essentially new details on the structure, shape, and density
of the sedimentary basins. Significant changes in the sedimentary thickness
and the depo-centre location have been found for the Anadyr Basin in its
continental part. Also, new details on the sedimentary thickness
distribution have been revealed for the central part of the Penzhin and
Pustorets basins; for the latter, the new location of the depo-centre has
been identified. The new model agrees well with the seismic data on the
sedimentary thickness for the offshore part of the Chauna Basin confirming
that the method is robust. The most significant lateral redistribution of
the thickness has been found for the Lower Cretaceous coal-bearing strata in
the northern part of the Zyryanka Basin, where the connection of two
coal-bearing zones, which was not previously mapped, has been identified.
Also, the new details on the sedimentary thickness distribution have been
discovered for the Primorsk Basin. Therefore, the new results substantially
improve our knowledge about the region, since previous geological and
geophysical studies were unsystematic, sparse, and limited in depth. Thus,
the implementation of the decompensative gravity anomalies approach provides
a better understanding of the evolution of the sedimentary basins and the
obtained results can be used for planning future detailed studies in the
area.
Deep oceanic submarine fieldwork with undergraduate students: an immersive experience with the Minerve software
Authors: Métois Marianne , Martelat Jean-Emmanuel , Billant Jérémy , Andreani Muriel , Escartín Javier , Leclerc Frédérique ,   the ICAP team
Published: December 2021

Abstract. We present the content and scripting of an active tectonic lab session conceived for third-year undergraduate students studying Earth sciences at Observatoire des Sciences de l'Univers in Lyon. This session is based on a research project conducted on the submarine Roseau active fault in the Lesser Antilles.
The fault morphology is particularly interesting to map as this structure in the deep ocean is preserved from weathering. Thus, high-resolution models computed from remotely operated vehicle (ROV) videos provide exceptional educational material to link fault morphology and coseismic displacement.
This class includes mapping exercises on geographical information systems and virtual fieldwork to provide basic understanding of active tectonics and active fault morphology in particular. The work has been conducted either in a full remote configuration via 3D online models or in virtual reality (VR) in a dedicated room using the Minerve software. During the VR sessions, students were either alone in the VR environment or participated as a group that included the instructor (physically in the classroom or remotely from another location), which is to our knowledge one of the first attempts of this kind in France. We discuss the efficiency of virtual fieldwork using VR based on feedback from teachers and students. We conclude that VR is a promising tool to learn observational skills in Earth sciences, subject to certain improvements that should be possible in the years to come.
Kepuasan Pengguna Wika Solar Water Heater Menggunakan Metode Importance Performance Analysis Dan Customer Satisfaction Index Pada CV Vania Jaya Plumbing
Authors: Irvani Andre , Arif Muhammad , Rahmi Hanifatul
Published: December 2021

Wika Solar Water Heater merupakan pemanas air yang memanfaatkan tenaga matahari sebagai sumber energi yang aman dan ramah lingkungan. Produk wika solar water heater ditujukan untuk keperluan perumahan/residensial dan komersial seperti Hotel, Apartemen, Rumah Sakit, Industri dan sebagainya.  Banyaknya perusahaan lain yang menawarkan produk dalam bisnis water heater saat ini menimbulkan permasalahan yang harus dihadapi oleh pihak perusahaan. Hal utama dalam permasalahan yang dihadapi seperti kualitas layanan yang diberikan oleh pihak perusahaan kepada pelanggan. Berdasarkan data tersebut peneliti merasa perlu dilakukannya penelitian untuk mengevaluasi tingkat kepuasan pelanggan, metode yang dapat digunakan diantaranya Importance performance analysis (IPA) dan Customer Statisfaction Index (CSI). Importance performance analysis memiliki beberapa kelebihan dibandingkan dengan metode lain. Hasil dari penelitian ini Peneliti memperoleh  nilai IPA untuk sumbu x sebesar 3,36 dan nilai untuk sumbu  y sebesar 3,38. Sedangkan untuk nilai CSI  sebesar 0,672 atau 67,2% yang berarti pada kisaran antara 0,61-0,80. Berdasarkan hasil CSI tersebut, maka kualitas pelayanan pada CV Vania Jaya Plumbing tersebut merasa puas terhadap kualitas pelayanan yang diberikan oleh karyawan selama ini.
Analisis Postur Tubuh Pekerja Usaha Kecil Menengah Batu Bata Pak Bachtiar
Authors: Rahma Pardosi Atika , Jenita Marbun Novri , Alfama Zamista Adelia
Published: December 2021

UKM Batu Bata Pak Bachtiar merupakan usaha pembuatan batu bata secara manual oleh Pak Bachtiar yang mendukung proses pembangunan perumahan. Pekerjaan secara manual berisiko menyebabkan stres pada kondisi fisik pekerja tersebut sehingga akan mengakibatkan terjadinya cedera seperti gangguan muskuloskeletal, yaitu cedera pada bagian otot, urat syaraf, urat daging, tulang, persendian tulang, dan tulang rawan. Pemindahan material secara manual apabila tidak dilakukan secara ergonomi maka menimbulkan terjadinya kecelakaan saat bekerja. Metode REBA (rapid entire body assesment) digunakan untuk menilai postur seorang pekerja secara keseluruhan dari pergerakan seluruh bagian tubuh mulai dari leher, punggung, lengan, pergelangan tangan dan kaki pekerja. Penerapan metode dalam penelitian ini ditujukan untuk mengurangi risiko cedera yang berkaitan dengan posisi, terutama pada otot-otot skeletal dan sebagai peringatan bahwa terjadi kondisi kerja yang tidak tepat ditempat kerja. Hasil penelitian dapat disimpulkan bahwa tingkat risiko yang rendah ada 2 kegiatan yaitu pada saat kegiatan mencetak tanah liat seberat 1,5 kg dan melepaskan tanah liat diatas bedeng. Sedangkan tingkat risiko tinggi terdiri dari 2 kegiatan yaitu pada kegiatan mengambil tanah liat diatas bedeng dan menyusun batu bata seberat 7,5 kg.
La diversas formas de la labor intelectual de Ortega y Gasset
Authors: Zamora Bonilla Javier
Published: December 2021

La labor intelectual de José Ortega y Gasset fue muy diversa y sus modos de actuación muy diferentes en distintos momentos de su vida. En este artículo se da cuenta sucinta de los mismos para mostrar cómo la cátedra, el periódico, las organizaciones políticas o las empresas editoriales que impulsó intentaron contribuir a un mismo afán de modernización de su país. Frente a la bibliografía que intenta resaltar alguno de estos aspectos, aquí se muestra cómo todos ellos formaron parte del quehacer orteguiano aunque con distinta intensidad en cada momento. Ortega representó esa función del intelectual contemporáneo que con sus ideas intentó influir en la opinión pública, pero sin abandonar nunca la concepción filosófica del intelectual como el que busca la verdad.
Plany reformy strefy euro – analiza porównawcza
Authors: BILSKI Janusz
Published: December 2021

Celem artykułu jest analiza, ocena i porównanie wybranych projektów reform strefy euro. Koncepcje przebudowy unii walutowej zostały tu podzielone na dwie grupy. Grupa pierwsza, reprezentowana przez „klasyków”, obejmuje metody integracji zaproponowane przez teorię optymalnego obszaru walutowego. Oznacza to szerokie wykorzystanie mechanizmów rynku w zarządzaniu strefą euro, co wiąże się ze zwiększeniem elastyczności całej gospodarki lub jej sektorów. Podejście drugie, prezentowane przez „instytucjonalistów”, zakłada ograniczenie elastyczności gospodarek i pełną synchronizację przebiegu cykli koniunkturalnych. Rzecznicy tej koncepcji widzą potrzebę zwiększenia roli instytucji i regulacji wspólnotowych w zarządzaniu gospodarką strefy euro. Realizacja koncepcji „klasyków” oznaczałaby radykalną zmianę dotychczasowych metod integracji, ponieważ proponują oni decentralizację polityki budżetowej i zarządzanie strefą euro przez mechanizmy rynku finansowego. Natomiast wdrożenie koncepcji „instytucjonalistów” jest tożsame z głęboką ingerencją władz wspólnotowych (ponadnarodowych) w zarządzaniu gospodarką – przy czym nie ma przekonujących dowodów, że synchronizacja cykli koniunkturalnych i budowanie silnej infrastruktury instytucjonalnej przyczyni się do zwiększenia efektywności procesów gospodarczych w krajach UGiW.
Needs Analysis of Maritime English teaching Materials Development for D4 Nautical Study Program of the Indonesian State Maritime Polytechnic (Polimarin)
Authors: Marselia Marselia , Rahayuningsih Mahsunah etik
Published: December 2021

It is a Research and Development study. This study aims to present the results of the needs analysis of Maritime English teaching materials in the D4 Nautical Study Program of the Indonesian State Maritime Polytechnic (Polimarin). The data in this study were obtained through a questionnaire was distributed and filled in by 60 respondents, namely active students of the D4 Polimarin Nautical Study Program. In addition, interviews were also conducted with lecturers who teach Maritime English and the Head of the D4 Nautical Study Program. The obtained data were analyzed qualitatively using needs analysis. The results of the analysis of the teaching material needs obtained show that basically the teaching materials have been provided by the lecturers, but have not been provided systematically in form of module or book. Students do not have teaching materials to handle and study them at home. The findings of this study will be used to develop and improve Maritime English teaching materials in the D4 Nautical study program. In the future, teaching materials will be developed in the form of module according to student needs in line with the applicable curriculum.
Methods of Estimating Correlation Coefficients in the Presence of Influential Outlier(s)
Authors: H.O. Etaga , I. Okoro , K.F. Aforka , L.O. Ngonadi
Published: December 2021

Correlation methods are indispensable in the study of the linear relationship between two variables. However, many researchers often adopt inappropriate correlation methods in the study of linear relationships which usually leads to unreliable results. Recurrently, most researchers ignorantly employ the Pearson method in a dataset that contained outliers, instead of more appropriate correlation methods such as Spearman, Kendall Tau, Median and Quadrant which might be suitable in the calculation of correlation coefficient in the presence of influential outliers. It is noted that the accuracy of estimation of correlation coefficients under outliers has been a long-standing problem for methodological researchers. This is due to low knowledge of correlation methods and their assumptions which have led to inappropriate application of correlation methods in research analysis. Five different methods of estimating correlation coefficients in the presence of influential outlier (contaminated data) were considered: Pearson Correlation Coefficient, Spearman Correlation Coefficient, Kendall Tau Correlation Coefficient, Median Correlation Coefficient and Quadrant Correlation Coefficient.
Exploring Grit: “Grit Linguistics” and Research on Domain-General Grit and L2 Grit
Authors: Oxford Rebecca , Khajavy Gholam Hassan
Published: December 2021

Grit is described as a unitary construct comprised of two elements, perseverance of effort (PE, or ongoing hard work) and consistency of interest (CI, referred to as “passion”). PE and CI together equate to success or achievement, according to the creator of the construct, Angela Duckworth (2016). Grit, which has supporters and detractors, says success is more dependent on PE and CI than on natural talent (Duckworth, 2016). This article presents “grit linguistics,” including the linguistic background of overall grit, PE, and CI and the appropriation of words from other fields into the grit vocabulary. This is followed by research on domain-general grit (grit across domains or areas) and domain-specific grit (L2 grit, i.e., grit for learning a second or foreign language). In addition, the article offers suggestions for future conceptions and assessment of grit.
Certain results associated with hybrid relatives of the q-Sheffer sequences
Authors: Khan Subuhi , Nahid Tabinda
Published: December 2021

The intended objective of this paper is to introduce a new class of the hybrid q-Sheffer polynomials by means of the generating function and series definition. The determinant definition and other striking properties of these polynomials are established. Certain results for the continuous q-Hermite-Appell polynomials are obtained. The graphical depictions are performed for certain members of the hybrid q-Sheffer family. The zeros of these members are also explored using numerical simulations. Finally, the orthogonality condition for the hybrid q-Sheffer polynomials is established.
Existence of solutions for quasilinear problem with Neumann boundary conditions
Authors: Lecheheb Samira , Lakhal Hakim , Maouni Messaoud
Published: December 2021

My abstract is:This paper is devoted to the study of the existence of weak solutionsfor quasilinear systems of a partial dierential equations which are the combinationof the Perona-Malik equation and the Heat equation. The proof of the main resultsare based on the compactness method and the motonocity arguments.
Petroleum Hydrocarbon Quarterly Boiling Range Distribution of Iraqi Crude Oil by Simulated Distillation Method
Authors: Alhead Aliaa K. , Khaleel Shatha F.
Published: December 2021

This study includes analysis of different crude oil stock for various field Iraqi oil by gas chromatography instrument, using simulated distillation technique for determining the  initial and final  boiling point distribution and specified compound distillation information (normal paraffins) (Recovery W/W) for (nC5 – nC44), ASTM-D5307 becomes the analytical method. This method need tow samples; the first one spiked with internal standard and the second without internal standard. This analysis for quantitative and qualitative oil characterization which is often useful for evaluating the range of hydrocarbons in crude oil using Simulated Distillation. The study was performed using:

Quarterly analysis of SIMDIS GC Distillation for three field (East Baghdad, Badra, Amara)

Comparison of analyzes of SIMDIS GC Distillation with Different API (light, intermediate, heavy) with Initial boiling point (IBP).

Finding experimental relationship between API and Initial boiling point (IBP):

        

The result of this study shows that the boiling point increase as the number of carbon is increase, the values of n-Pentane (nC5) to n- Tetratetracontane (nC44) (w/w) changes from winter and summer (difference in temperatures), Positive correlation between C6 and C5 with API, where their percentages increase with increasing API for crude oil and C6 and C5 are lower in summer than in winter due to the evaporation of light components of the samples in summer. Initial boiling point increase as the API is decrease that mean in crude oil have heavy component increases and light component decrease (inverse relationship).
تقييم السحنات الدقيقة لتكوين قره جيني (الترياسي المتأخر) وسيناريو تطور حوضه الرسوبي في شمالي وشمال غربي العراق
Authors: الحمداني عبد العزيز م , علي محمد س , الدباغ مها م
Published: December 2021

يركز البحث الحالي على تقييم السحنات الدقيقة لتكوين قره جيني (الترياسي المتأخر) في أربعة ابار نفطية، هي:  قند (Kd-1) وعين زاله (29AZ-) وبطمة (Bm-15) وعلان (Aa-2). ويتألف التكوين من تعاقب من الحجر الجيري البني الداكن والمسود والدولومايت والانهايدرايت والاشرطة السجيلية. وبالإضافة الى السحنتين الانهايدرايتية والسجيلية فقد ميزت عشرة سحنات كاربونايتية دقيقة تبعاً للمحتوى الاحيائي والصخري والنسيج. واعتماداً على نتائج السحنات الدقيقة والصخارية، تبين ان تكوين قره جيني قد ترسب تحت طيف واسع من البيئات الترسيبية ضمن مواقع المنزلقات الكاربونايتية. وتعد ترسبات المزلق الداخلي هي الأكثر شيوعاً ضمن تعاقبات التكوين في بئري عين زاله وعلان. بينما تظهر ترسبات المزلقين الأوسط والخارجي، فضلاً عن ترسبات المزلق الداخلي،  بوضوح ضمن تعاقبات بئري بطمه وقند. واستنادا الى سطوح عدم التوافق فقد قُسم التكوين الى ثلاث وحدات طباقية، تبدأ بعمر الكاريني المبكر ضمن الترياسي المتأخر وتنتهي في الجوراسي المبكر. ويتباين سمك هذه الوحدات في مقاطع الدراسة، وذلك نظراً لتباين الأحداث التكتونية ومعدلات التجلس.
http://associacaopaulistamedicina.org.br/assets/uploads/revista-spmj/5806f8c85455ba6901f539e5e9a26c22.pdf
Authors: Cacho Roberta de Oliveira , Moro Carla Heloisa Cabral , Bazan Rodrigo , Guarda Suzete Nascimento Farias da , Pinto Elen Beatriz , Andrade Suellen Mary Marinho dos Santos , Valler Lenise , Almeida Kelson James Silva de , Ribeiro Tatiana Souza , Jucá Renata Viana Brígido de Moura , Piemonte Maria Elisa Pimentel , Paschoal Eric Homero Albuquerque , Minelli César , Pagnussat Aline de Souza , Pedatella Marco Tulio Araújo , Pontes Neto Octávio Marques , Fontana Ana Paula , Conforto Adriana Bastos
Published: December 2021

Background: Preliminary evidence suggests that access to multidisciplinary rehabilitation is insufficient after hospital discharge of individuals with stroke. Objective: The AReA study intends to collect data about access to rehabilitation in different Brazilian regions. Methods: Seventeen public health centers will participate in the study. Each center will include 36 participants (n = 612). Patients with 6 months and less than oneyear post-ictus, age ≥18 years-old, stroke confirmed by CT or MRI and with any neurological impairment after stroke will be included. In each center, researchers will train the team on the application of the Brazilian versions of the Rankin Modified Scale and the NIH Stroke Scale. The survey consists of the following questions: 1. In the first 6 months after discharge from stroke, were you treated by a Physiatrist /Physiotherapist / Speech / Neurologist / Psychologist / Occupational Therapist?; 2. Has a treatment program been established?; 3. Has this program been or is it being carried out?; 4. On discharge, have you been referred to any rehabilitation service?; 5. Did you look for any service on your own?; 6. Did you receive any guidance about stroke?; 7. Considering that rehabilitation would be indicated for its improvement, how would you like it to be carried out (hospitals, centers, home)? Results: At the moment, 13 centers obtained ethical approval, and three of them started data collection (n=55). Conclusion: The results of this project will be relevant to plan strategies for effective rehabilitation within the Unified Health System in Brazil.
Clinical-epidemiological profile of the hospitalized patient with Alzheimer in the State of São Paulo
Authors: Silva Vinícius de Oliveira , Lins Lucas Costa , Coelho Elton Marcio Marques
Published: December 2021

Background: Alzheimer’s Disease (AD) is the most common form of dementia and its prevalence practically doubles every five years from the age of 60. The progression of the disease determines cognitive deterioration, impairment of basic daily activities and the need for multiple hospitalizations. Objectives: Characterize the clinical-epidemiological profile of hospitalizations for Alzheimer’s in the state of São Paulo, in the period from 2015 to 2019. Design and Setting: Epidemiological, descriptive and retrospective study with quantitative analysis. Methods: Data provided from the Hospital Morbidity System (SIH-SUS) of the Ministry of Health. Results: A total of 2270 hospitalizations were identified, with a decrease in the number of hospitalizations over the five years (590 in 2015 and 435 in 2019). There was a predominance in people over 80 years old. About 68% of hospitalizations were on an urgent basis. The mortality rate increased 286.23% between 2015 and 2019, and the region with the highest number of hospitalizations was the greater São Paulo (n=1318). Conclusion: The increase in the mortality rate, associated with the reduction in the number of hospitalizations over the years and the predominance of hospitalizations on an urgent basis, may indicate that hospitalizations occur in the presence of a more severe disease, whether due to better management of moderate disease or late diagnosis of its complications. The predominance of hospitalizations in the greater São Paulo region indicates a centralization of health services and technological resources.
Mesenchymal stem cells modulate the gene expression of T- type Calcium Channel Subunit Alpha 1G (Cav3.1) in acute phase of epilepsy
Authors: Silva Vitoria Pimentel da , Provenzi Laura , Becker Nicole , Zocche Giovani , Leal Gabriel , Pinzetta Giulia , Alcará Allan , Ghilardi Isadora , Zanirati Gabriele , Marinowic Daniel , Zanatta Angela , Rodrigues Felipe , Costa Jaderson Costa da
Published: December 2021

Introduction: Temporal Lobe Epilepsy (TLE) is a disorder caused by neuronal electrical imbalance, clinically manifested by spontaneous and recurrent seizures1,2. Its pathogenesis involves channelopathies of calcium channels, which contributes to hyperexcitability and hypersynchrony in TLE3 . About 30% of patients do not respond to drug treatment4 , making it necessary to develop new therapeutic alternatives, such as cell therapy. This work aimed to evaluate the modulation of mesenchymal stem cells (MSCs) in the calcium channel CACNA1G (Cav3.1) gene expression. Methods: MSCs were extracted from Wistar rats bone marrow and then cultured and transplanted intravenously and intranasally in the control and epileptic groups. The brain was collected 1 and 7 days after transplantation to analyze gene expression. Results: The analysis showed that treated animals had greater gene expression, compared to animals not treated in the epileptic and control group, in both days and administration routes. Furthermore, epileptic animals that were not treated had a low or negative expression of the gene. The epileptic rats that were treated, on the other hand, had a marked increase in gene expression e in the prefrontal cortex. Conclusion: This up-regulation noted on the treated groups raises the hypothesis that MSCs would be using these channels to modify the microenvironment5 , intensifying Cav.3.1 transcription and contributing to tissue regeneration by neurodifferentiation6,7. This is supported by the increase in the calcium influx present in the early stages of neuronal maturation8,9. Thus, MSCs can modulate gene expression in the pilocarpine-induced animal’s brain, making Cav3.1 a target to be explored in epilepsy.
Systematic review with meta-analysis on the use of antihyperglycemic agents as a preventive factor for cognitive losses in diabetic patients
Authors: Nakanishi Deborah Ayumi Alves , Aragão Diego Armando Barbosa , Teixeira Claudio Eduardo Corrêa
Published: December 2021

Background: Blood glucose variations are generally associated with predisposition to the development of dementia in diabetes patients. And there is a controversy in the literature about whether the use of antihyperglycemic agents can(not) promote protective effects on cognition. Design and setting: we used a systematic review with meta-analysis to evaluate whether the evidence in the literature points to a protective or harmful effect of antihyperglycemic agents on cognition. Methods: PubMed, Science Direct and Scielo databases were used to collect articles in English, published between 2005 and 2020. Articles of reflection/opinion, monographs/theses/dissertations, and animal research were excluded. The blinding of authors during the searches contributed to search independence. Of 1,329 articles selected, 30 were adequate, but only 3 of these provided quantitative data from 53 cognitive tests, which were used for meta-analysis (random effect model), performed using R. Results: Funnel plot shows no publication bias. Forest plot, on the other hand, shows that literature points to the use of antihyperglycemic agents by patients as preventive of cognitive losses (standard mean difference equal to -0.18 [95% confidence interval between -0.29 and -0.06]). Conclusion: Evidence of the preventive effect of cognitive losses through the use of antihyperglycemic agents such as metformin should be further investigated, in order to better clarify this therapeutic potential.
Corticobasal syndrome with Balint syndrome: a clue for Alzheimer disease pathology
Authors: Ferreira João Henrique Fregadolli , Maieski Amanda , Disserol Caio , Teive Helio Afonso Ghizoni
Published: December 2021

Context: Balint syndrome (BS), first described in 1909, has three core features: optic ataxia, oculomotor apraxia and simultanagnosia, and has been described after various conditions amongst vascular, infectious, demyelinating and degenerative diseases1 . It has already been reported concomitant with corticobasal syndrome (CBS)2 . Case report: 59 year-old male without history of previous diseases presented with behavior changes in the last two years. He had a previous diagnosis of “stroke” because frequent falls to the left side and difficulty in using his left hand for simple daily activities. After that, he gradually evolved with visual problems (bumped into objects inside his house), fear of walking or sitting, and required constant assistance for basic activities of daily living. On physical examination he presented with clear visuospatial dysfunction, characterized by simultanagnosia, oculomotor apraxia and optic ataxia. Bilateral asymmetric upper limb apraxia (worse on left side), dystonic posturing and stimulus-sensitive myoclonus in the left arm were also present. No signs of parkinsonism or language/speech disturbances were identified. Brain MRI showed severe asymmetric biparietal lobe atrophy (right more than left). DISCUSSION: The pathologic findings underlying CBS are variable, including Corticobasal Degeneration, Progressive Supranuclear Palsy, Frontotemporal Lobar Degeneration and Alzheimer Disease (AD). The association of BS and CBS favors the possibility of AD pathologic findings3 . Imaging methods like FDG-PET have recently been shown to be capable of distinguishing AD-related CBS from those associated with other pathologies4 . FDG-PET is not widely available in our country; than the presence of BS in CBS patients may individualize their treatment.
Scenario of serious treatment of serious cranioencephalic traumatism in the state of São Paulo
Authors: Hernandes Júnior Paulo Roberto , Rosa Juliana de Souza , Lopes Patrick de Abreu Cunha , Silva Bárbara Tisse da , Silva Heloá Santos Faria da , Gomes Tiago Veiga , Côrtes Paula Pitta de Resende , Feitosa Jhoney Francieis
Published: December 2021

Background: Cranioencephalic trauma consists of injury to brain tissue, being one of the main causes of death in the world. Objectives: Analyze the current panorama of conservative treatment procedures for severe traumatic brain injury performed in the State of São Paulo for 13 years and correlate the current epidemiology with the results obtained. Methods: A literature review and observational, descriptive and transversal data collect on conservative treatment for severe traumatic brain injury, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed, were carried out. Results: There were 30,850 hospitalizations, representing a total expenditure of R$ 100,307,344.78, with 2008 being the year with the highest number of hospitalizations (2,596), although 2017 was the year responsible for the highest amount spent during the period ( R$ 9,042,101.44). Of the total procedures, 997 were performed on an elective basis and 21,917 on an urgent basis, with 9,054 occurring in the public sector and 9,005 in the private sector. All 30,850 considered to be of high complexity. The total mortality rate in the 13 years studied was 36.32, corresponding to 11,204 deaths. The mortality rate for elective procedures was 49.15 compared to 35.40 for urgent procedures, whereas in the public sector it was 35.97 compared to 33.44 for the private sector. The average total hospital stay was 12.4 days, with an average cost of R$ 3,251.45. Conclusion: There is a high mortality rate, mainly in elective procedures and in the public sector.
Death of adults by stroke in Santa Catarina
Authors: Maia Maria Eduarda Coelho da
Published: December 2021

Background: Stroke is the second leading cause of death worldwide, including 10% of deaths. In addition to death, stroke can cause irreversible paralysis, permanently disabling the patient. Objectives: The present study proposes an analysis of the epidemiological variants that interfere with the number of adult deaths from stroke in the state of Santa Catarina (SC). Design and setting: This is an ecological study, whose area of analysis was the state of Santa Catarina, located in Brazil. The population studied was the group of individuals aged 20 to 59 years old living in the area studied and who died of a stroke (ICD-10 I64) in the period from January 2005 to December 2019. Methods: The data used were obtained from DATASUS. The variables analyzed were: sex, color/race, and region. Results: The present study found a greater predominance of the white race in both sexes in the state of SC with 86% of total deaths. The male gender was higher in all age groups and years analyzed presenting a percentage of 56%, and the female with 44%. The Mountainous and the South regions of Santa Catarina, two less industrialized regions and with the two lowest GDP’s in the state, had the first and third highest prevalence of deaths, respectively 20% and 16%. Conclusions: The state of Santa Catarina showed a higher prevalence of deaths from stroke in the analyzed period in white adults, males, and residents of the Mountainous region and South of the state.
Case report: Intracranial Arterial Dolichoectasia
Authors: Depieri Lorena Dellagnesi , Viana Lorena Souza
Published: December 2021

Introduction: Intracranial arterial dolichoectasia (IADE) is a diameter increase and/ or a long and tortuous path in one or more Intracranial arterial. Most patients keep asymptomatic and eventually present neurological complications (ischemia, bleeding or compression of adjacent structures). At around 12% of the patients with stroke present this kind of intracranial dilated, which 80% are in the posterior cerebral circulation, mainly in basilar artery. Objective: Report an unusual case of IADE refractory to the clinical treatment. Method: The information was obtained by reviewing the medical record, after the patient’s consent. Result: Patient, 51, male, hypertensive and dyslipidemic, with abdominal aortic aneurysm surgery and an incidental diagnosis in 2015 of fusiform basilar artery aneurysm, presented in March 2020 after cervical flexion, dysarthria, horizontal diplopia when looking to the right and ptosis to the left. The computed cranial angiotomography showed a basilar artery of 1.8 cm diameter fusiform aneurysm, compressing the pons and medulla oblongata, with no signs of ischemia or bleeding. He was discharged from hospital with clopidogrel without deficits, however, after 30 days, manifested a new focal neurological deficit with spontaneous remission. During the investigation a skull resonance was presented without ischemia, transcranial doppler with circulatory delay and without embolization. In view of the recurrence, an exchange in clopidogrel for ticagrelor was decided, which was kept stable for 30 days. Conclusion: IADE may be an incidental finding or even a life-threatening illness. Thus, these cases remain a major challenge in clinical practice and in interventional radiology.
The relation between COVID-19 and cerebrovascular diseases
Authors: Oliveira Francisco Gabriel Cabral , Moura Juliana Paiva Ribeiro , Oliveira Matheus Henrique , Jesus Mylena Teles de
Published: December 2021

Introduction: Covid-19 is characterized by respiratory syndrome and has symptoms that affect the central nervous system such as headache, anosmia, hypercoagulability, etc. In this sense, it is known that the virus shows tropism by the receptors of the angiotensin-converting enzyme 2 (ACE2), becoming a gateway to the neurological system, which can cause complications. Is to relate the infection by COVID-19 and the increase in cerebrovascular diseases. Methods: A literature review was carried out using search for scientific articles in PubMed, in April / 2021, with a filter in the last 5 years, using the descriptors “Covid”, “Cerebrovascular Diseases” and “Man” associated with the Boolean operator AND. Results: 53 articles were found, of which 19 were selected for research. There is a higher frequency of neurological symptoms in patients with COVID-19 than in patients without the disease. The effect of binding the virus to ACE2 receptors is to activate a cascade of cytokines, which tends to lead to serious complications. For this reason, severe coagulopathies can be caused, increasing products of the degradation of C-reactive protein, D Dimer, fibrinogen and thrombocytopenia. The increase in cerebrovascular events also occurs because the antithrombotic, neuroprotective, antihypertensive effects, among others, of the alternative renin-angiotensin system in the brain are interrupted due to COVID-19. Conclusion: It was seen that cerebrovascular events are related to the course of COVID-19, in which patients may develop several serious complications, such as encephalitis, strokes and vascular thrombosis. Thus, the pathophysiology of this disease is related to an inflammatory process.
Preliminary phytochemical analysis and antibacterial study of crude extract from Hamelia patens stems
Authors: Kanchana V. , Kumar G. Venkat , Shalini R. V.
Published: December 2021

The present study aimed to analyse the phytochemical and antibacterial activity of different extracts of the tropical plant Hamelia patens Jacq. (Rubiaceae). The antimicrobial activity was carried out using agar well diffusion method. Hexane, petroleum ether, ethanol and chloroform stem extracts (100 μL of 50 mg/mL each) were introduced into the wells separately and allowed it to undergo incubation. After the incubation time was over, the plates were observed for zones of inhibition and compared with positive control ciprofloxacin at a concentration of 30 μM. These results provided evidence that the tested plant extracts possess antimicrobial properties which can be tested further in the development of novel antimicrobial agents.
El glamping, como tendencia del turismo en Ecuador en tiempos de COVID-19
Authors: Jácome Arboleda Janeth Stefania
Published: December 2021

La presente investigación se desarrolló con el objetivo de analizar el aporte de la modalidad glamping como alternativa de hospedaje en Ecuador durante la pandemia de COVID-19. La investigación se fundamentó en un enfoque cuantitativo, con alcance descriptivo de diseño no experimental transversal. Se solicitó la participación de tres establecimientos turísticos que ofertan el servicio de alojamiento Glamping en Ecuador, como también, 20 personas que hacen uso del glamping. Para la recolección de datos se aplicó el cuestionario digital. Los datos fueron procesados con un análisis estadístico descriptivo. Los resultados revelaron que los usuarios del glamping tienen preferencias características del servicio, entre estos el conectivismo de internet, la tecnología, los servicios individualizados y distanciados, la bioseguridad con medidas optimas y eficientes, además de la remota cercanía a los establecimientos turísticos y la conexión con la naturaleza. El estudio indicó que a medida que aumenta la demanda de este tipo de hospedaje, aumenta el número de opciones de alojamiento. Promover esta modalidad turística facilita el rápido crecimiento e ingreso económico que está en auge a nivel mundial, como alternativa de hospedaje en Ecuador durante la pandemia COVID-19.
The Effect of Distance Education on Self-efficacy towards Online Technologies and Motivation for Online Learning
Authors: ÖZÜDOĞRU Gül
Published: December 2021

This research aimed to investigate the effect of distance education during the COVID-19 pandemic on psychological counselor candidates’ self-efficacy perceptions towards online technologies and their motivation for online learning. Single group pretest-posttest model, a quantitative method, was used in the research. The study participants were third-year students at the Faculty of Education, Psychological Counseling and Guidance Department of a state university in the fall semester of 2020-2021. Demographic Information Form, Online Technologies Self-Efficacy Scale and Online Motivation Scale were used as data collection tools. As a result of the research, it was observed that the psychological counselor candidates’ self-efficacy for online technologies and online learning motivation scores were above the average. It was concluded that the distance education used during the COVID-19 pandemic caused a statistically significant difference in psychological counselor candidates’ self-efficacy towards online technologies, but did not cause a difference in their online learning motivation. There was no significant difference in self-efficacy according to gender and place of residence. However, while there was no significant difference in motivation according to gender, a significant difference was observed in regards to the place of residence in favor of citycenter. It is important to present psychological counselor candidates’ perceptions and motivations in regards to distance education, which is an ongoing process at the moment, for their professional development.
In Junior High School Boys, a Comparison Of Hollow Sprint and Acceleration Sprint Methods on the Sprinter 100 Meters
Authors: Akbari Rian , Pardilla Herli , Zulfah Zulfah
Published: December 2021

The  purpose  of  the study. The purpose of this study was to describe the increase in extracurricular spint abilities of male students at SMP Negeri 03. The research method was this study using an experiment with a quasi-experimental type of research and the research pattern used in this study was a nonequivalent control group design.
Materials and methods. This design involves two groups, namely the experimental group and the control group, and the time of the study was carried out in June 2021. The subjects of this research were 10 extracurricular students of SMP Negeri 03 Bangkinang, Kampar Regency.
Results. The results of this study can be concluded that the results of the 100 meter sprint ability of male extracurricular students at SMP Negeri 03 Bangkinang Kampar Regency with an average sprint ability of 100 meters 0.933, thus it can be concluded that by using the hollow sprint method on acceleration can improve the ability to run 100 sprints.
Conclusions. Based on the results of data analysis, description, testing of research results and discussion, conclusions can be drawn based on the results of calculations that have been carried out, a significant value of 1.080 1.054 is obtained. Thus, the hypothesis states that there is a significant difference between the hollow sprint and accelerating sprint exercises on the 100-meter running speed of male students of SMP Negeri 3 Bangkinang in the 2020/2021 academic year, which is acceptable.
Assessment of the Results of Trade Cooperation of the CIS Member States
Authors: Mantusov Vladimir B. , Tkachenko Marina F.
Published: December 2021

The article assesses the results of the implementation of multilateral cooperation of the CIS member states in the field of trade. It has been established that despite the fact that, on the whole, the CIS member states fulfill their obligations under the Free Trade Zone Agreement, there are a number of contradictions and barriers that impede the implementation of a coordinated trade policy and increase mutual trade. Analysis of individual indicators of the dynamics of mutual trade showed a low intensity of interaction between the CIS member states, their orientation towards third countries. Russia remains the main export and import partner for most of the CIS countries, which itself is much focused on partners outside the CIS. At the same time, foreign trade relations within the CIS are characterized by insignificant diversification, and their direction and intensity depends on a number of economic and political factors.