bluuebunny/crossref_metadata_2025 huggingface dataset:
NILAI-NILAI PENDIDIKAN KARAKTER DALAM PROGRAM INTERPROFESSIONAL EDUCATION (IPE)
Authors: Rahman Faisal
Published: April 2022

The development of technology and the challenges of the times that are getting bigger with the dissemination of information that is so massive can affect the formation of the character of the younger generation so that a program is needed that can shape the character of the younger generation. Character education is an important alternative solution that can be implemented in the era of globalization given the rapid flow of information and the influence of foreign cultures that are increasingly unstoppable with digital technology. One alternative that can be implemented to be able to carry out character education is Interprofessional Education (IPE), which has been widely applied in the world of health. This article provides a conceptual framework for how Interprofessional Education (IPE) can be developed and applied in character education because the basic competencies contained in Interprofessional Education (IPE) have values ​​and principles that are in line with character education. In this article, the author explores the values ​​and principles in Character Education in the Interprofessional Education (IPE) program.
PERSPEKTIF KOMUNIKASI VISUAL PADA PENGEMBANGAN BAHAN AJAR SAINS BERBASIS DIGITAL UNTUK SISWA SD
Authors: Pamungkas Ageng Satria
Published: April 2022

Bahan ajar berbasis digital memiliki peran penting sebagai sumber belajar yang tepat digunakan di era kenormalan baru. Bahan ajar berbasis digital tersusun dari berbagai materi yang relevan dan disusun sesuai dengan kebutuhan pembelajaran. Spesifik pada komunikasi visual, bahan ajar berbasis digital mengoptimalkan kemampuan siswa menyerap informasi melalui penglihatan dengan cepat dan lengkap 70%-80%. Bahan ajar berbasis digital berbentuk visual memiliki pengaruh lebih besar terhadap peningkatan hasil belajar siswa di era kenormalan baru. Penelitian ini bertujuan untuk menghasilkan bahan ajar sains berbasis ditinjau dari perspektif komunikasi visual, dan mengetahui peningkatan hasil belajar siswa setelah menggunakan bahan ajar sains berbasis digital. Penelitian menggunakan langkah, meliputi: (a) define, (b) design, (c) develop, dan (d) disseminate. Subjek uji coba kelompok kecil 6 siswa. Subjek uji coba lapangan 14 siswa. Hasil penelitian ini menunjukkan bahwa bahan ajar sains berbasis digital yang dihasilkan sangat layak ditinjau dari perspektif komunikasi visual, yaitu validasi ahli materi skor 3,70/4,00, hasil validasi ahli media memperoleh skor 3,74/4,00, respon siswa pada uji coba kelompok kecil skor 2,80/3,00 dan uji coba lapangan skor 2,89/3,00. Peningkatan hasil belajar siswa menggunakan produk skor tinggi. Hal tersebut didasarkan dari hasil perolehan pre-test dan post-test siswa dengan N-gain 0,71 dan signifikansi 0,002.
A COMPARATIVE STUDY OF KINDS, FUNCTION, AND POSITION OF QUESTION WORDS IN ENGLISH AND BAHASA BATAK TOBA
Authors: Tampubolon Sahlan
Published: April 2022

Toba in terms of kinds, functions and positions. The data were taken from the Holy Bible written on Matthew’s book Chapter 1-28 with English and Bahasa Batak Toba Version. The question words found there were contrasted to see the similarities and differences. The research findings showed that English has nine types of question words, they are: Who, This study is about the similarities and differences of question words in English and Bahasa Batak Whom, What, Where, When, Why, How, Which, and Whose. While in Bahasa Batak Toba, there are eleven types of question words, they are Aha, Ise, Boha, Dia, Andigan, Nandigan, Piga, Sadia, Boasa, Mahua, and Marhua. In terms of functions, Both English and BahasaBatak Toba’s question words are used to ask for person, place, time, thing, reason, manner, activity, and possession. The position of English question words occurred at the beginning or in the middle of an interrogative sentence, while Bahasa Batak Toba’s question words take place at the beginning,in the middle, and at the end of interrogative sentences.
The THE EFFECT OF THE AUDIO LINGUAL METHOD ON STUDENTS’ SPEAKING ACHIEVEMENT
Authors: Sidabutar Usman
Published: April 2022

The objective of this research is to find the effect of the Audio- Lingual Method on speaking achievement of the second grade of students on English Department of the HKBP Nommensen University Medan in academic year 2018/ 2019 which is focused on dialog speaking encompassing  the pronunciation, vocabulary, grammar, fluency, and comprehension. This design of the research was the experimental quantitative design which applied two variables, such as a dependent variable as a speaking ability and an independent variable as an Audio- Lingual Method. Having analyzed the data, the writer found that the Audio- Lingual Method affects students’ speaking ability. There was a different mean score obtained from the both control group 65, 28 and the experimental group is 8,031. The result of the calculation is: Tabs > table (P= 0.05); (df= 48) And 8,031 > 2,010 (P = 0.05); (df = 48). The alternative hypothesis of the method is accepted. The students’ speaking ability by using the Audio- Lingual Method shows better results compared to those who did not teach by using the Audio- Lingual Method. It is suggested for English teacher to use the Audio- Lingual Method as the way to improve the students’ English speaking ability.
Compilador e intérprete en línea de diagramas de flujo con fines didácticos
Authors: Arellano Pimentel J. Jesús , Solar González Rocío , Nieva García Omar S. , Canedo Ibarra Sabrina Patricia
Published: April 2022

This work deals with the development, fine-tuning and testing of an online flowchart compiler and interpreter. The development methodology takes as a frame of reference the software reengineering process model, in conjunction with the Object-Oriented Hypermedia Design Method (OOHDM). The software product obtained is a web application for educational purposes that differs from other tools mainly in three aspects: supporting the Polya problem-solving heuristics, create flowcharts following the recommendations for graphic symbology of the American National Standards Institute (ANSI), and be freely available on the internet. The online compiler and interpreter fine-tuning ran on two web browsers that support modal dialog boxes, one for personal computers and one for mobile devices. In addition, compliance tests with the W3C standards, loading speed tests, and a user experience perception test were applied to 22 students of a preparatory course on algorithms. The results obtained in all the tests carried out are considered satisfactory and in accordance with the current context of the students.
PENGARUH KERAGAMAN PRODUK, HARGA DAN LOKASI TERHADAP KEPUTUSAN PEMBELIAN PADA MINIMARKET RUSDI WIDORO PAYUNG
Authors: Fandiyanto Randika , Prianto Fajar Wahyu
Published: April 2022

This study aims (1) to determine the effect of product diversity, price and location partially on purchasing decisions (2) to determine the effect of product diversity, price and location simultaneously on purchasing decisions (3) to find out which among the diversity of products, prices and locations  which has a dominant influence on purchasing decisions.  The method used in this research is quantitative method.  The results of multiple linear regression analysis are Y = 2,888E-16 + 0,186 X1 + 0,475 X2 + 0,184 X3 + 0,088 e.  Partially, product diversity has a significant positive effect on purchasing decisions with a value of 2,094> 1,985, price has a significant positive effect on purchasing decisions with a value of 5,317> 1,985, location has a significant positive effect on purchasing decisions with a value of 2,065> 1,985.  Simultaneously the diversity of products, prices, and location together have a significant positive effect on purchasing decisions with a value of 11,172> 2.70.  The dominant influential variable in this study is the price variable with a value of 5,317.
Review on tuberculosis
Authors: Srujana  , P Narayana swamy , P Venkatesh
Published: April 2022

Tuberculosis has been one of the contagious diseases in human communities during the past 50 years. World Health Organization (WHO) has been reported that one third of the world’s population is infected with Mycobacterium tuberculosis this high occurrence of infection has caused a large number of morbidity and mortality. Which is partly due to serious adverse reactions induced by Anti-TB drugs. Mycobacterium tuberculosis normally affects the lungs along with other parts of the body examples: lymph nodes, spin, cervix and kidney etc.  India is the highest TB burden country accounting more than one third of the global occurrences. There are many adverse drug reactions (ADR's) are developed during the treatment of Tuberculosis with anti-tubercular drugs. The detection of adverse drug reactions (ADR's) has become increasingly significant because of introduction of a large number potent toxic chemicals. Pharmacovigilance is an arm of patient care and surveillance ADR'S effect both the children and adults with carrying the magnitudes causing morbidity and mortality. A good pharmacovigilance study will identify the risks within the shortest possible time after the medicine has been marketed and will help to establish or identify the risk factors. The current prospective observational study of six months duration was designed to assess the rate of adverse drug reactions (ADRs) occurrence by anti-tubercular drugs in patients admitted in the department of Chest & Tuberculosis from whom a proper consent obtained. The results of the study showed that the incidence of all major adverse effects was 1.08 per 50 person’s month of exposure. The occurrence of any major side effect in the study was associated with female sex and increase in age. In our study the major cause of admission was adverse drug reactions 47(47%).In our study Hepatitis was observed in 11 (11.56%) patients, leading to the death of 3 patients. In conclusion, Anti-TB drugs that used in tubercular treatment were result in significant adverse effects both in quantity and severity. These reactions may lead to hospitalization, and even death. To confirm this hypothesis many more studies with large population is needed.
A review on: materials for biomedical implants
Authors: K Praveen Kumar , M Durga Srinivasa Rao , P Venkatesh
Published: April 2022

The implant of biomaterial is a key factor for the long-term success of implants. The biological environment does not accept completely any material so to optimize biological performance; implants should be selected to reduce the negative biologic response while maintaining adequate function Synthetic materials for surgical implant devices have evolved from the early metallic systems to a variety of material combinations and composites. This article is an effort to review various biomaterials of implants that were used in the past and as well as the latest material used now. Further improvements in existing systems require a continuation of the multidisciplinary approach to the laboratory, experimental animal, and human clinical research.
The Prognostic Effect Of The NPM1 Mutation And The FLT3-ITD Genes In Acute Promyelocytic Leukemia
Authors: Phuong Vu Minh
Published: April 2022

Background: The Nucleophosmin 1 gene mutation (NPM1mut) is considered a favorable clinical outcome in patients with acute myeloid leukemia (AML) with normal chromosome, and this outcome may be reduced with the presence of an internal tandem repeat of the Fms-like tyrosine kinase 3 gene (FLT3-ITD). However, the effect of NPM1mut on patients with acute promyelocytic leukemia (APL) remains unclear. Our objective was to analyze the prognostic effect of the NPM1mut gene and the FLT3-ITD gene in patients with APL.

Methods: Sixty patients with new APL diagnoses underwent RT-PCR detection of the NPM1mut and FLT3-ITD genes, and accepted treatment with ATRA and chemotherapy. The presence and combinations of genotypes were compared in association with overall survival (OS) and progression- free survival (PFS) outcome.

Results: Twenty- eight patients had positive FLT3-ITD with a rate of 46.7%, nine had positive NPM1mut with a rate of 15%. Patients with FLT3-ITD positive have worse OS and PFS compared to FLT3-ITD negative (p=0.027; 0.008, respectively), but there were no statistically significant differences in OS, PFS between the groups: NPM1mut positive and NPM1mut negative (p=0.209; 0.352, respectively), NPM1mut positive/FLT3-ITD positive and NPM1mut negative/FLT3-ITD positive (p=0.235; 0.444, respectively), NPM1mut positive/FLT3-ITD negative and NPM1mut negative/FLT3-ITD negative (p=0.376; 0.324, respectively).

Conclusions: The FLT3-ITD gene confers a poor prognosis in patients with acute promyelocytic leukemia, but the NPM1mut gene had no effect on efficacy and did no change the prognostic value of FLT3- ITD.
Tagungsbericht / Conference Report: "Wortbildung und Konstruktionsgrammatik" 2.–3. Dezember 2021; Haus der Universität, Düsseldorf
Authors: Stutz Lena
Published: April 2022

Am 2. und 3. Dezember 2021 fand im Haus der Universität in Düsseldorf die von Katrin Hein (IDS Mannheim) und Sascha Michel (RWTH Aachen) organisierte Tagung "Wortbildung und Konstruktionsgrammatik" statt, welche von der Deutschen Forschungsgemeinschaft (DFG) sowie der Gesellschaft von Freunden und Förderern der HHU (GFFU) finanziert wurde. Aufgrund der aktuellen Corona-Lage wurde die Tagung in einem hybriden Veranstaltungsformat durchgeführt, sodass neben den Veranstaltern und fünf ReferentInnen vor Ort weitere fünf ReferentInnen aus Deutschland, den Niederlanden, Italien und Frankreich zugeschaltet wurden. Daneben fand sich mit 46 digital Teilnehmenden aus dem In- und Ausland ein großer und disziplinär breit aufgestellter Rezipientenkreis aus LinguistInnen, GermanistInnen, RomanistInnen, AnglistInnen sowie Literatur- und ÜbersetzungswissenschaftlerInnen ein, die nicht nur die Vortragsdiskussionen bereicherten, sondern insgesamt die bestehende Relevanz des Tagungsthemas unterstrichen.
 
Dieser Beitrag ist ursprünglich im Peter-Lang-Verlag erschienen (https://www.ingentaconnect.com/contentone/plg/jwf/2022/00000006/00000001/art00003)
The Cocreation of Place Meaning at Small-Scale Elite Youth-Based Sport Event
Authors: Abdykadyrova Aisulu
Published: April 2022

The study uses Morgan's model of experience space as a framework for understanding the cocreation of place meaning at the 2017 Canadian Championships in Rhythmic Gymnastics (2017 CCRG). The efforts of event organizers (experience managers and marketers) to shape place experiences at
the event was considered in conjunction with the visitors' motivations and their interpretation of meanings inclusive of the social and cultural interactions at the event. Research methods included semistructured interviews and e-mail questionnaires. Five place-based themes emerged through
categorical aggregation analysis: function, tourist activities, community, performance, and emotion. These findings demonstrated the relevance of the Morgan's model of experience space. However, modifications to the model were recommended. These include the combination of the achievement,
hedonic pleasure and personal meanings components under the label of emotion, and the introduction of a new "performance" component. The 2017CCRG shaped place meaning for athletes, parents, and organizers.
Perceptions of Sexual Assault at Music Festivals
Authors: Williams Karen J. , Murray Duncan W.
Published: April 2022

This article examines perceptions of sexual assault at music festivals. The context of a music festival tacitly encourages women to dress in a way that is consistent with the atmosphere of the event, and in ways that are "on trend." However, there is strong evidence that victims who
dress in more revealing attire face issues in relation to victim blame, with their own culpability questioned. Given recent reports on sexual assault at music festivals, research investigating perceptions by the general public of sexual assault at such festivals, is timely. Utilizing netnography
and an instrumental case study approach, data were collected via a discussion forum on the Daily Mail website, with over 900 responses examined. Employing thematic analysis, core themes to emerge included: victim blame, self-responsibility for safety and its connection with dress, context
and location, that no assault occurred, and aspects of the victim's appearance. These themes are unpacked and then discussed as reflective of the broader issue of rape culture. Practical implications regarding policy and event reputation are provided.
Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family
Authors: Manon Stéphen
Published: April 2022

The budding yeast Saccharomyces cerevisiae, a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell death, it has however always been a powerful tool to gain information on the mechanisms of apoptosis in general and on Bcl-2 family in particular. This is a short survey of 25 years of experiments that have provided, and at times initiated, insights into the molecular mechanisms underlying the function of Bcl-2 family members.
Effect of Hyperlipidemia on Aneurysm: Fuzzy Inference Analysis
Authors: Imene Bouharati , Khaoula Bouharati , Slimane Laouamri
Published: April 2022

Introduction: The abdominal aortic aneurysm is a silent disease. This disease is often detected by accident when diagnosing another disease. There are many factors that promote this disease. These factors are mainly related to age. Doppler ultrasound can detect this disease. But often and for more details, we resort to the scanner. Since the factors that characterize this disease are multiple and complex, this study proposes to analyze them using artificial intelligence techniques. Method: During a period of two years between 2019 and 2020, around 100 patients are diagnosed at the Sétif hospital in Algeria as well as in other private clinics in the city. At each diagnosis, the diameter of the aorta is measured and related to hyperlipidemia. A system of analysis using the principles of fuzzy inference is proposed in the data processing. Result: With the development of this application, it becomes possible to introduce the variables of hyperlipidemia randomly at the input of the system to automatically read the diameter of the abdominal aorta possibly planned. Conclusion: By considering hyperlipidemia as a fuzzy variable, because it is a function of other complex physiological parameters, this fuzzy analysis makes it possible to compensate for these uncertainties. The diameter of the abdominal aorta predicted for the hyperlipidemia will be as precise as possible. This tool can be considered as a preventive aid for the aneurysm.
Prognostic value of the preoperative systemic immune-inflammation index in patients with cholangiocarcinoma: a meta-analysis
Authors:   Department of Gastroenterology，The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, Liu Xuechun , Jiang Yueping , Sun Xueguo , Zhao Jianjian , Zhang Lingyun , Jing Xue
Published: April 2022

Review question / Objective: This meta-analysis is aimed to investigate the prognostic value of the preoperative systemic immune-inflammation index in patients with cholangiocarcinoma. Condition being studied: Surgical resection remains the mainstay of curative therapy for CCA. The systemic immune-inflammation index (SII) is a significant prognostic factor in some cancer types. However, the prognostic value of SII in patients with cholangiocarcinoma (CCA) is still not clear. This meta-analysis is aimed to investigate the prognostic value of the preoperative systemic immune-inflammation index in patients with cholangiocarcinoma.
Research on Remaining Useful Life Prediction Method of Rolling Bearing Based on Health Indicator Extraction and Trajectory Enhanced Particle Filter
Authors: Luo Peng , Hu Jiao , Zhang Lun , Hu Niaoqing , Yin Zhengyang
Published: April 2022

Aiming at the difficulty of mining fault prognosis starting points and constructing prognostic models for remaining useful life (RUL) prediction of rolling bearings, a RUL prediction method is proposed based on health indicator (HI) extraction and trajectory-enhanced particle filter (TE-PF). By extracting a HI that can accurately track the trending of bearing degradation and combining it with the early fault enhancement technology, early abnormal sample nodes can be mined to provide more samples with fault information for the construction and training of subsequent prediction models. Aiming at the problem that traditional degradation rate models based on PF are vulnerable to HI mutations, a TE-PF prediction method is proposed based on comprehensive utilization of historical degradation information to timely modify prediction model parameters. Results from a rolling bearing prognostic study show that prediction starting points can be accurately detected and a reasonable prediction model can be conveniently constructed by the RUL prediction method based on HI amplitude abnormal detection and TE-PF. Furthermore, aiming at the RUL prediction problem under the condition of HI mutation, RUL prediction with probability and statistics characteristics under a confidence interval can be obtained based on the method proposed.
Yatak Üretimi Yapan Bir Mobilya İşletmesinde İş Gören Verimliliğinin Düşmesine Yol Açan İş Zaman Kayıplarının Belirlenmesi ve Simülasyon Yöntemi ile Kapasite Artırımı
Authors: ÇETİN Tahsin
Published: April 2022

Türkiye; hızla artan nüfusu, avantajlı coğrafyası, avantajlı coğrafyanın ihracata katkıları ile dünya çapındaki gelişimini sürdürmeye devam etmektedir. Ülkemizde harekete geçen en önemli sektörlerden biri de hiç kuşkusuz, yatak sektörüdür. Son yıllarda yatak sektöründe yaşanan gelişmeler, yenilikler ve sektörün örnek dayanışması, yatak sektörünü olumlu yönde etkileyen faktörler olmuştur. Ancak yatak sektörü, fazla işgücü gerektiren karmaşık bir yapıya sahiptir. Bu yüzden yatak üreten işletmelerin, düşük verimlilik, ürün miktarının azlığı ve üretim planlama zorluğu gibi sorunları olduğu bilinmektedir. Mobilya endüstrisinde, verimliliği olumsuz etkileyen faktörlerin, verimliliği düşürmesi dolayısıyla önleyici tedbirler alınmalıdır. Mobilya endüstrisinde verimin düşmesine neden olan kayıp iş zamanlarında etkili iki temel faktör vardır. Bunlardan birincisi, yönetimden ve iş görenlerden kaynaklanan iş zaman kaybı, diğeri ise, ürünün tasarımı ve üretim yöntemleri hatalarından kaynaklanan iş zamanı kayıplarıdır. Mobilya endüstrisinde meydana gelen iş zamanı kayıplarının araştırılması alınacak önlemler açısından önem taşımaktadır. İşgücü kayıplarının yoğunluğu ve sebep-sonuç ilişkileri açısından araştırılması uzun yıllardan beri diğer ülkelerde ve ülkemizde de yapılmaktadır. Ancak mobilya işletmelerinde böyle bir çalışmaya rastlanmamıştır. Bu çalışmada; büyük ölçekli bir mobilya işletmesinde iş gören verimliliğinin düşmesine yol açan iş zamanı kayıplarının bulunması ve çözümlerinin üretilmesi amaçlanmıştır. Bu çalışmada atölye tipi üretim yapan ve işgücü yoğun olan özel bir yatak işletmesinin “A Grubu” yatak üretim hattı ele alınmıştır. Bu çalışma kapsamında; • Mevcut üretim sisteminin ARENA simülasyon yazılımıyla modellenmiş, • Üretim miktarını kısıtlayan kayıplar belirlenmiş, • Kayıpların yaşandığı noktalarda iyileştirmeler yapılmış, • Mevcut kapasitenin arttırılmasını sağlayacak yollar alternatifler türetilmiş ve oluşturulan bu iki senaryodan, birinci senaryo “A Grubu” yatak üretim miktarının kapasitenin yaklaşık 32 adet (% 65,31) artarak toplam üretim kapasitesinin 81 adede çıktığı gözlemlenmiş, • Belirlenen yolların alternatiflerin ARENA simülasyon yazılımıyla modellenmesi ve elde edilen sonuçların analizi ile üretim kapasitesinin artırılması amaçlanmıştır.
Six cases of appendiceal cancer: Literature review, diagnosis and treatment
Authors: Tran Nguyen Ha
Published: April 2022

Appendiceal cancer is a very rare disease. Based on 6 cases of appendiceal cancer who were admitted to the Internal Medicine of Breast, Gastroenterology, Hepatology, Urology, Department, Oncology Hospital of Ho Chi Minh City from September 2019 to March 2021, we evaluate the available literature review about diagnosis and treatment of appendiceal cancer. Four out of 6 cases were diagnosed with stage IV disease, only 1 case was in stage II, and 1 case with undermined stage. All cases were treated with Capecitabine-based chemotherapy, 5 out of 6 were treated with Capecitabine and Oxaliplatin combination, while the other was treated with Capecitabine monotherapy. We didn’t use hyperthermic intraperitoneal chemotherapy in any of those cases because of technical limitations at Ho Chi Minh City Oncology Hospital. Up to the time of reporting, all 6 cases are being monitored for survival.
Traces of past reintroduction in genetic diversity: the case of the Balkan chamois
Authors: Rezić Andrea , Safner Toni , Iacolina Laura , Buzan Elena , Šprem Nikica
Published: April 2022

The translocation of wild animal species became a common practice worldwide to re-establish local populations threatened with extinction. Archaeological data confirm that chamois once lived in the Biokovo Mountain but, prior to their reintroduction in the 1960s, there was no written evidence of their recent existence in the area. The population was reintroduced in the period 1964–1969 when 48 individuals of Balkan chamois from the neighbouring mountains in Bosnia and Herzegovina were released. The main objective of this study was to determine the accuracy of the existing historical data on the origin of the Balkan chamois population from the Biokovo Mountain and to assess the genetic diversity and population structure of the source and translocated populations 56 years after the first reintroduction. We used 16 microsatellite loci to analyse the genetic structure of three source chamois populations from Prenj, Čvrsnica and Čabulja Mountains and from Mt. Biokovo. Both STRUCTURE and GENELAND analyses showed a clear separation of the reintroduced population on Biokovo from Prenj’s chamois and considerable genetic similarity between the Biokovo population and the Čvrsnica–Čabulja population. This suggests that the current genetic composition of the Biokovo populations does not derive exclusively from Prenj, as suggested by the available literature and personal interviews, but also from Čvrsnica and Čabulja. GENELAND analysis recognized the Balkan chamois from Prenj as a separate cluster, distinct from the populations of Čvrsnica and Čabulja. This suggests that the Neretva River and the state M17 road are geographic barriers for the species dispersal, as they form a genetic boundary.
Un 4 e P au triangle d’autonomie : la Proximité comme fonction contenante dans les situations de stress
Authors: Wely Olivier
Published: April 2022

Poussé par une inquiétude bien humaine et très professionnelle, notre auteur, enseignant en maternelle, s’est interrogé sur l’impact qu’a pu avoir le confinement sur les jeunes enfants de sa classe. Après avoir questionné les familles à ce sujet, notre auteur nous emmène dans sa réflexion sur les difficultés qu’ont pu rencontrer les petits dans leurs liens d’attachement et la préservation de leur espace de sécurité. Il envisage alors que les 3 piliers du soutien classique des 3 P, Protection, Puissance, Permission soient complétés par un 4 e P, celui de la Proximité, afin d’offrir une présence contenante au processus d’autonomisation de l’enfant. BE
Frontières et points stratégiques de l’œuvre
Authors: Larroux Guy
Published: April 2022

Longtemps tenue pour négligeable, la spatialité propre à la littérature a fortement requis la poétique contemporaine, suscitant de nombreux travaux sur les seuils, la ponctuation, la division des textes et des œuvres. Appliquées au xix e  siècle, ces approches ont une pertinence spéciale en raison de l’évolution du dispositif des lettres, des interférences entre sphères médiatique et littéraire, de la montée en puissance de l’image et du roman. La question de la découpe que les créateurs se posent à toute échelle (cycle, série, feuilleton, recueil, livre), le lecteur se la pose aussi, et notamment le lecteur critique occupé des questions de composition – notion vénérable à laquelle la poétique du démarcatif, attentive à l’évolution littéraire et à la question des supports, a donné un nouveau fond.
Novel split quality measures for stratified multilabel cross validation with application to large and sparse gene ontology datasets
Authors: Tiittanen Henri , Holm Liisa , Törönen Petri
Published: April 2022

Multilabel learning is an important topic in machine learning research. Evaluating models in multilabel settings requires specific cross validation methods designed for multilabel data. In this article, we show that the most widely used cross validation split quality measure does not behave adequately with multilabel data that has strong class imbalance. We present improved measures and an algorithm, optisplit, for optimizing cross validations splits. Extensive comparison of various types of cross validation methods shows that optisplit produces more even cross validation splits than the existing methods and it is among the fastest methods with good splitting performance.
Surface disinfection with white-violet illumination device
Authors: Hessling Martin , Meurle Tobias , Hoenes Katharina
Published: April 2022

The spread of infections, as in the coronavirus pandemic, leads to the desire to perform disinfection measures even in the presence of humans. UVC radiation is known for its strong antimicrobial effect, but it is also harmful to humans. Visible light, on the other hand, does not affect humans and laboratory experiments have already demonstrated that intense visible violet and blue light has a reducing effect on bacteria and viruses. This raises the question of whether the development of pathogen-reducing illumination is feasible for everyday applications. For this purpose, a lighting device with white and violet LEDs is set up to illuminate a work surface with 2,400 lux of white light and additionally with up to 2.5 mW/cm2 of violet light (405 nm). Staphylococci are evenly distributed on the work surface and the decrease in staphylococci concentration is observed over a period of 46 hours. In fact, the staphylococci concentration decreases, but with the white illumination, a 90% reduction occurs only after 34 hours; with the additional violet illumination the necessary irradiation time is shortened to approx. 3.5 hours. Increasing the violet component probably increases the disinfection effect, but the color impression moves further away from white and the low disinfection durations of UVC radiation can nevertheless not be achieved, even with very high violet emissions.
Variants of Julia and Mandelbrot sets as fractals via Jungck-Ishikawa fixed point iteration system with $ s $-convexity
Authors: Antal Swati , Tomar Anita , Prajapati Darshana J. , Sajid Mohammad
Published: April 2022

In this paper, we generate some non-classical variants of Julia and Mandelbrot sets, utilizing the Jungck-Ishikawa fixed point iteration system equipped with $ s $-convexity. We establish a novel escape criterion for complex polynomials of a higher degree of the form $ z^n + az^2 -bz + c $, where $ a, \; b $ and $ c $ are complex numbers and furnish some graphical illustrations of the generated complex fractals. In the sequel, we discuss the errors committed by the majority of researchers in developing the escape criterion utilizing distinct fixed point iterations equipped with $ s $-convexity. We conclude the paper by examining variation in images and the impact of parameters on the deviation of dynamics, color and appearance of fractals. It is fascinating to notice that some of our fractals represent the traditional Kachhi Thread Works found in the Kutch district of Gujarat (India) which is useful in the Textile Industry.
An analysis of finger and hand injuries in children in a tertiary paediatric emergency department
Authors: Surke Carsten , Kunzli Michael , Vogelin Esther , Garcia Daniel , Lollgen Ruth M.
Published: April 2022

AIMS OF THE STUDY: This study set out to examine the association between current subspecialty (paediatric and hand surgery) consultation practice for children with hand and finger injuries presenting to a tertiary paediatric emergency department and length of stay in the paediatric emergency department. Also, incidence and injury pattern of hand and finger injuries in this patient group were analysed.
METHODS: This was a retrospective cross-sectional study, which was undertaken as a clinical audit service. All patients under 17 years presenting to our paediatric emergency department with hand and finger injuries over a 17-month period were included in the analysis. We studied incidence and injury mechanism, current subspecialty referral practice, as well as paediatric emergency department and hospital length of stay.
RESULTS: We identified 929 children for inclusion in the analysis. The most frequent reasons for presentation were hand contusions (25.5%) and fractures (20.8%). Paediatric emergency medicine physicians alone managed 845 patients (90.6%), paediatric surgery referral occurred in 50 (5.4%) and hand surgery consultation in 37 (4.0%) cases. Mean length of stay in the paediatric emergency department was 154 min and significantly longer when subspecialty review occurred. Hospital admission occurred in 87 cases (9.3%).
CONCLUSIONS: Involvement of subspecialties in the care of hand and finger injuries was associated with significantly increased length of stay in the paediatric emergency department. We discuss obstacles and enablers for timely patient referral and management. We suggest the implementation of referral guidelines, tailored to the individual emergency department, to reduce unnecessary patient journey delays and to ensure higher quality repair of complex hand injuries by the appropriate surgeon, with better outcomes. Making use of the emergence of multiple surgical subspecialties for targeted treatment of paediatric finger and hand injuries might be desirable.
Cetuximab-Induced Acneiform Eruption: A Case Report
Authors: GÜNER Büşra , EVRENSEL Türkkan , OYUCU ORHAN Sibel
Published: April 2022

Epidermal growth factor receptor (EGFR) monoclonal antibody inhibitors are used to treat metastatic colorectal cancers. Cetuximab, an EGFR inhibitor drug, targets specific molecular pathways and does not cause the severe systemic side effects seen in cytotoxic chemotherapy. Herein, we presented a case who developed acneiform eruptions during cetuximab treatment.
A Rare Cause Of Anemia Etiology: Gastrointestinal Stromal Tumors
Authors: ŞEN Hacer , KIRIK Ali , BÜLBÜL Erdoğan , DOĞRU Teoman
Published: April 2022

Gastrointestinal stromal tumours (GIST) are rare neoplasms originating from the interstitial cajal cell in the gastrointestinal tract. Herein, we presented a 51-year-old male patient with GIST which we investigated the aetiology of iron deficiency anaemia and found the tumour.
Thyroid Storm Associated With Diabetic Ketoacidosis: Case Report
Authors: ADA Gül , ERSOY Canan , ERTÜRK Erdinç , ÖZ GÜL Özen , CANDER Soner , HOCAOĞLU Erhan , MERCAN SARIDAŞ Filiz , AYDEMİR Ensar , ATEŞ Coşkun
Published: April 2022

Various autoimmune diseases may accompany type 1 diabetes. Autoimmune thyroid diseases are common in these patients. Herein, we presented a type 1 diabetic female patient with diabetic ketoacidosis accompanied by a thyroid storm.
Development of AA Amyloidosis in a Patient with Psoriasis: A Case Report
Authors: SEZEN Mehmet , ŞAHİN Müge , YILDIZ Abdülmecit , ORUÇ Ayşegül , GÜLLÜLÜ Saide , YAVUZ Mahmut , GÜLLÜLÜ Mustafa , DİLEK Kamil , ERSOY Alparslan
Published: April 2022

Psoriasis is a chronic, recurrent, inflammatory and common skin disease of unknown aetiology. Amyloidosis is defined as a heterogeneous group of diseases in which generally soluble plasma proteins accumulate in the extracellular space as insoluble abnormal fibrils. Type AA amyloidosis is a late and severe complication of chronic inflammatory disorders and some chronic infections. Although psoriasis is a common inflammatory skin disease, the development of amyloidosis is rare. Herein, we presented a case of psoriasis who developed AA-type amyloidosis.
Indomethacin induced toxic hepatitis: a case report
Authors: SAKAR Orkun , TEKER Tufan , NAK Selim Giray , UĞRAŞ Nesrin
Published: April 2022

Nonsteroidal anti-inflammatory drugs deare widely used worldwide for analgesic, antipyretic and anti-inflammatory purposes. Indomethacin is a potent nonsteroidal anti-inflammatory drug and can cause severe liver damage. Few cases of idiosyncratic toxic hepatitis have been reported. Here, we present a case of indomethacin-induced toxic hepatitis that improved with methylprednisolone treatment.
Thrombocytopenic Thrombotic Pupura Presenting with Neurological Symptoms : A Case Report
Authors: ÇAKIR Yağmur , ORHAN Bedrettin , OZKOCAMAN Vildan , ÖZKALEMKAŞ Fahir
Published: April 2022

Thrombotic thrombocytopenic purpura (TTP) is thrombotic microangiopathy caused by decreased activity of ADAMTS13, a von Willebrand factor-degrading metalloprotease. Here, we present a male patient with neurological symptoms, diagnosed with TTP and successfully treated with plasmapheresis.
Post-transplant Lymphoproliferative Disorder Following Kidney Transplantation,
Authors: CANDAR Ömer , ZOR TURNA Tuğçe
Published: April 2022

Posttransplant lymphoproliferative diseases are complications that develop after solid organ transplantation. Primary EBV infection is one of the most important risk factors. After deceased kidney transplantation, we presented a young male patient diagnosed with diffuse large B-cell lymphoma.
Nasal Cavity Neuroendocrine Carcinoma and Synchronous Breast Cancer: A Case Report
Authors: HACIMUSTAFAOĞLU Asuman Şebnem , DELİGÖNÜL Adem
Published: April 2022

Primary malignancies of the nasal cavity and paranasal sinuses are rare and diagnosed late. Herein, we presented a female patient with nasal cavity neuroendocrine carcinoma and synchronous breast cancer.
Pembrolizumab Induced Hypothyroidism: A Case Report
Authors: YİĞİT Sidelya Ecem , GÖKMEN İffet Beril , OKUTURLAR Yıldız
Published: April 2022

Immune checkpoint inhibitors inhibit the inhibitory mechanism on the immune system, their side effects may be autoimmune diseases that occur due to excessive immune response. Pembrolizumab is an immune checkpoint inhibitor targeting PD-1. The most common clinical presentations of thyroid injury induced by pembrolizumab are destructive thyroiditis and overt hypothyroidism. Herein, we presented a case of pembrolizumab induced hypothyroidism.
Adoption Readiness Assessment Model based on SaaS Maturity Level in SMEs
Authors:   Information Systems Department, School of Information Systems, Bina Nusantara University, Jakarta 11480, Indonesia, Ongowarsito Henkie , Prabowo Harjanto , Gaol Ford Lumban
Published: April 2022

Abstract— The acceleration of digital transformation in the industrial revolution 4.0 triggered by Cloud Computing created an expansion of the commercialization of IT services. SaaS ERP is one of the fastest growing cloud computing services and is a solution for SMEs. Although SaaS ERP uses a cloud base, it turns out that not all vendors provide uniform services. The difference in the services provided depends on the differences in Metadata, Security and shared services. These different services can be classified in 4 SaaS maturity levels consisting of level 1: Custom/Ad Hoc, level 2: Configurable, 3: Standardization/Multi-Tenant, and level 4: Scalable and Multi-tenant. The current research on measuring SaaS ERP adoption readiness has not considered this maturity level, even though this difference will have a different impact on each adoption factor. Continuing from the previous research which formulated the factors and weights of adoption, the purpose of this study is to understand the considerations of SMEs in adopting SaaS ERP that is deployed at different maturity levels. By using expert judgment, an assessment rubric is created for each factor at each maturity level. The expert assessment produces a range maturity index which is combined with the weight of each factor to assess the maturity level of SMEs' readiness to adopt SaaS ERP. The assessment rubric developed with expert validation and SMEs can be use as a tool to measure the maturity level of SMEs' readiness to adopt SaaS ERP Keywords— Adoption Readiness, Expert Judgement, ERP, SaaS ERP, SMEs, SaaS Maturity Level
Parking Availability Identification System in Urban Areas of through Image Processing Lima - Peru
Authors:   Universidad Tecnológica del Perú & Av. Alfredo Mendiola 6377, Los Olivos, Peru, Claudio Brian Meneses , Rios Waldemar Rios , Bernuy Luis Tarmeño , Huamaní Enrique Lee
Published: April 2022

Abstract— A challenge of the automobile is to find a solution to this problem of vehicle parking, since the number of vehicles grows annually and there is no sophisticated system that allows to reduce waiting times and perform this task more efficiently, becoming an important aspect for the best use of the capacity of the existing parking area, being the main focus the increase in the number of vehicles that affect the undistributed filling of the parking lot generating waiting time and in many cases desertion in supermarkets. In our country it is necessary to increase parking spaces since many people have vehicles and the number of vehicles continues to increase every year, although there are companies dedicated to this area, they do not achieve the comfort of people for various reasons such as vehicle safety and the distance in which the vehicle is. In view of this problem, this article made a system of identification of availability in parking lots in urban areas of Lima - Peru through image processing to facilitate the user's search for a parking area that is free. Through the development of the system, the objective of detecting the free spaces so that users can park their vehicles according to a previous complete evaluation conducted by the system with an efficiency of 98.14% was met. Keywords-- image recognition, MATLAB, image processing
Case Analysis of Overseas Countries in Project-based Learning for Vocational Education and Workforce Development
Authors:   Assistant professor, Duksung Women`s University, Seoul, Korea, Jang Seung-hwan
Published: April 2022

Abstract— Recently, the education community is paying attention to project-based learning as an educational method that can effectively develop future capabilities, such as ‘4C’ or ‘21st century capabilities’ of communication, collaboration, critical thinking, creativity. Project-based learning has been recognized as one of the learning methods that flourished in the United States in the early 20th century and as a synonym for efforts to break away from cramming education. Since then, project-based learning has had a status as an educational method, affecting school education in the United States, the former Soviet Union, and Europe, but has also stagnated. However, recent project-based learning is a situation that raises new interest in projects by linking schools and businesses as well as school education. Project-based learning is an educational method that induces learners to naturally learn in the process of solving tasks (projects) proposed by themselves in cooperation with other learners. In relation to this, project-based learning is actually making excellent results in strengthening learners' capabilities and calculating final results, but there are also various controversies about project-based learning. In fact, it is true that both instructors and learners are still having difficulties in designing and conducting classes, and accordingly, problems arise in the application of teaching and learning situations for vocational education and workforce dvelopment. Therefore, in order to solve these points, reduce the gap between the presented theory and field application, and revitalize related research, I would like to analyze the cases of overseas countries and present implications. Keywords—Project-based Learning, PBL, Vocational Education and Workforce Development, VEWD, Case Analysis
A Novel Approach for Enhancing the Network Life Time of Secure ML_RPL Routing Protocol in Internet of Things by Using PROB_ATT_SCHEME
Authors:   Dept. of CSE, Andhra University, Visakhapatnam, Andhra Pradesh, India, Golla Kishore , Setty S. Pallam
Published: April 2022

Abstract-- IoT devices are having self-configuration in nature for establishing adhoc networks to monitor physical activities like environmental sensing, Intelligent Traffic Management Systems (ITMS) and so on even in unmanned areas. Benefits of these networks are numerous and few of them are no infrastructure and deploying spontaneously, cost effective set up of temporary and dynamic networks and so on. Moreover, characteristics like unreliable wireless links, resource constraints related to energy and power and dynamic topology, makes the protocols that are developed recently to ignore the security needs with the intention of satisfying quality of service (QoS). IoT makes the jobs easier and smarter, but still security mechanisms are challenging for resource constrained devices like denial of service attacks (Stuxnet), blackhole attacks are the examples of attacks which maliciously controls these devices causing damage. Remote Attestation (RA) is one tool which efficiently identifies a malicious entity in the network. However, the proposed tool not suitable for large size mobile IoT networks, where nodes are connected in heterogeneous manner with resource constraints for the nodes. It is understood that it is necessary to do the necessary research for extending the network life time of resources constraint nodes existing in the network along with secure connection between nodes of the network, In present work, proposed a probability-based attestation scheme (PROB_ATT) for improving routing and security in IoT network. With the help of the estimated probability value of network path, attestation value is included in the network along with data. With application of trickle time, attestation is verified and data transmission is performed. After estimation of probability within network data transmission is performed based on trust mechanism. Simulation analysis stated that PROB_ATTT scheme reduces energy consumption, packet loss ratio and delay as 20%, 10% and 5% respectively when compared with Machine Learning based RPL protocol. Whereas the other important performance metrics: energy efficiency, throughput and Packet delivery rate performance is improved around 20% than ML based RPL protocol. Keywords-- Attestation scheme, Probability attestation scheme (PROB_ATT), Security, Trust Mechanism, Trickle Timer, MAC layer,RPL,ML_RPL protocol
UTICAJ GODINE I SORTE SOJE NA BROJ I MASU ZRNA PO BILJCI
Authors:   Institute of Field and Vegetable Crops, Novi Sad, Serbia, Đukić Vojin , Miladinović Jegor , Mamlić Zlatica , Dozet Gordana , Bajagić Marija , Miljaković Dragana , Marinković Jelena
Published: April 2022

The number of grains and the mass of grains per plant are morphological characteristics that directly affect the achieved soybean yield. The aim of this research is to examine the influence of year and different varieties on the number of grains and grain weight per plant. In 2017 and 2021, the number and weight of grains per plant were statistically significantly lower compared to other years of research. The observed morphological characteristics have the highest values in the soybean variety with the longest vegetation period, the number of grains per plant was statistically significantly higher in the Rubin variety compared to the Sava and Galina varieties, while the grain weight per plant was statistically significantly higher in the Rubin variety on the Galina variety and statistically significantly higher in relation to the Sava variety.