bluuebunny/crossref_metadata_2025 huggingface dataset:
KEAMANAN DAN KERAHASIAAN DOKUMEN REKAM MEDIS BAGIAN FILING RUMAH SAKIT ROEMANI MUHAMMADIYAH SEMARANG TAHUN 2020
Authors: Anjani Sylvia , Sugiyanto Zaenal , Agiwahyuanto Faik , Azizah Layla Nur , Wulandari Fitria
Published: January 2023

Latar Belakang: Berdasarkan pengamatan awal masih ditemukan petugas selain rekam medis atau selain petugas filing yang masuk ke ruang filing. Pada pintu filing yang menuju ke bagian pendaftaran pintu tidak terkunci. Melindungi keamanan serta kerahasiaan ruang filing sangat diperlukan agar terhindar dari kejahatan, kecelakaan dan lainnya.Tujuan: mendeskripsikan keamanan dan kerahasiaan dokumen rekam medis diruang filing RS Roemani Muhammadiyah Semarang.Metode: Jenis penelitian yang digunakan adalah deskriptif dengan metode observasi dan wawancara.Hasil: Penelitian menunjukan dari segi aspek fisik sudah aman, sampul dokumen RM terbuat dari bahan kertas Art Karton 230gr. Ruangan filing tidak tersedia APAR, kamfer dan tracer. Petugas masih melakukan aktifitas makan dan minum di ruang filing. Pintu ke-2 tidak terkunci dan masih ada selain petugas rekam medis yang masuk ke ruang filing.Kesimpulan: Sebaiknya pihak rumah sakit melengkapi ruang filing dengan APAR, tracer, kamfer dan melakukan pemeliharaan kebersihan di ruang filing. Untuk menjaga kerahasiaan rekam medis pasien sebaiknya rumah sakit dengan tegas melarang selain petugas filing untuk masuk ke ruang filing.
ANALISIS PERILAKU KELUARGA BALITA DAN KONDISI LINGKUNGAN FISIK RUMAH TERHADAP KEJADIAN PNEUMONIA PADA BALITA DI INDONESIA: LITERATURE REVIEW TAHUN 2012-2021
Authors: Shiddiq Husein Umarush , Azizah R , Jalaludin Juliana Binti , Sulistyorini Lilis , Arfiani Novi Dian
Published: January 2023

ABSTRACTPneumonia is an acute respiratory infection that adversely affects the lungs caused by viruses, bacteria or fungi, where pneumonia accounts for 15 percent of under-five deaths in the world and resulted in 808,694 children dying in 2017 (WHO, 2019). The purpose of this study was to analyze family behavior and the condition of the physical home environment with the incidence of pneumonia in children under five in Indonesia. The method in this study is a literature review. The data sources in this study came from Google Scholar, Science Direct, and Pubmed then sorted according to the inclusion and exclusion criteria and obtained 28 research articles.The results of the analysis of several studies show that smoking habits of family members (83.3%), use of mosquito coils (50%), house occupancy density (72.7%), and type of house floor (50%) are associated with the incidence of pneumonia in children under five. . It is hoped that the puskesmas can make efforts to control the risk of pneumonia in toddlers by conducting periodic counseling about the dangers of smoking to toddlers and how to overcome them, as well as relating to factors that affect the physical condition of the home environment, especially in the density of residential houses with a house building area that should be sufficient. for the occupants in it.Keywords: Pneumonia Incidence, Literature Review, Family behavior, Home Physical Environment Condition.ANALISIS PERILAKU KELUARGA BALITA DAN KONDISI LINGKUNGAN FISIK RUMAH TERHADAP KEJADIAN PNEUMONIA PADA BALITA DI INDONESIA: LITERATURE REVIEW  TAHUN 2012-2021
FAKTOR RISIKO PERILAKU KELUARGA DENGAN KEJADIAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) PADA BALITA DI INDONESIA: META ANALYSIS TAHUN 2015-2020
Authors: Menanti Laste , Azizah R , Latif Mohd Talib , Leonita Acknes , Sumantri Arif , Jauharoh Siti N.A , Rizaldi Muhammad Addin
Published: January 2023

countries. The proportionate mortality rate (PMR) due to ARI in children under five in the world is 16%, two thirds of deaths are infant deaths. The purpose of this study was to analyze the risk factors for family behavior with the incidence of ARI in children under five in Indonesia. The method in this study uses meta-analysis to find the effect size value using JASP software version 0.9.2. Sources of data in this study came from Google Scholar, Science Direct, and Pubmed then sorted according to inclusion and exclusion criteria and obtained 37 research articles. The results of secondary data from the meta-analysis method found that the variable using mosquito coils had a 1.094 times greater risk of experiencing the incidence of ARI in toddlers. The conclusion from the results of the meta-analysis that has a higher level of risk on the family behavior variable is the family smoking habit variable. Efforts to control the risk of ARI in toddlers by conducting periodic counseling or promotion about the dangers of ARI disease, reducing the factors that influence the incidence of ARI in toddlers by providing good nutrition for the growth and development of infants, as well as communities or families who have toddlers to stop smoking, especially in the house or near.Keyword: ARI incidence, family behavior, and toddlers
El corazón en el COVID-19
Authors: Calderón Velasco Rolando
Published: January 2023

Un análisis de datos de 154,000 veteranos que han tenido COVID-19, los investigadores encontraron que un año después de haberse recuperado de la infección aguda, los pacientes tenían un aumento en el riesgo de problemas cardiovasculares, incluyendo ritmo cardíaco anormal, inflamación del músculo cardíaco, coágulos sanguíneos, derrames cerebrales, infartos de miocardio e insuficiencia cardíaca.
A Natural History of Logistics and Other Studio Briefs: Problem Spaces for Planetary Design
Authors: Parikka Jussi
Published: January 2023

Peer-reviewed article forthcoming in Cultural Politics journal issue 19:3 (2023). The article stems from the project Operational Images and Visual Culture (funded by the Czech Science Foundation grant 19-26865X). Abstract: This article addresses the question of the planetary through three practices that relate to design and architectural pedagogy and research as well as the broader context of Anthropocene discussions. From Strelka Institute’s Terraforming program to the Terra Forma book by Aït-Touati, Arènes, and Grégoire and a discussion of Royal College of Art’s Architecture program’s studio “Something in the Air: Politics of the Atmosphere” the article focuses on framing of “problem spaces” (Celia Lury’s term) through studio briefs as well as experimental visualization and mapping. While discussing some methodological underpinnings of planetarity as such a problem space, the article mobilizes the neologism a natural history of logistics to analyse practices of scale in the critical design studio briefs and discourses at the centre of the article. The term is pitched as one temporary conceptual anchor for a specific relation to technological framing of a polyscalar Earth as it emerges in design discourses and practice-based approaches.
Founders’ Forum Classroom Simulation
Authors: Sacco Michael
Published: January 2023

Classroom simulations are a great way for students to engage subject matter and become more motivated to learn. For this constitution-building simulation, the class will be divided into two equal-membered factions. Each side will be able to discuss their positions on issues as a group pertaining to the government and governance of this new nation within their own group. Once both groups finish building their respective constitutional ideas, they will discuss their concepts with the other group and have meaningful class discussion to find a way to ratify a single constitution. By participating in this simulation, students will be able to: understand and explain the importance of establishing a constitution and government, analyze conflicting perspectives to determine how to make decisions and compromises on issues, communicate effectively in a group setting, develop critical thinking and problem-solving techniques, and practice mindfulness abilities in working with others in finding a common solution.
Förenklad bild av naturvetenskap i skolan
Authors: Bossér Ulrika
Published: January 2023

Kunskap om naturvetenskapernas karaktär kan underlätta elevers förståelse av ämnesinnehållet samt främja deras intresse. En studie från 2015 visar dock att lärare ofta fokuserar på fakta i undervisningen och presenterar naturvetenskap som en universell metod som leder till säker kunskap.
Enhanced antifouling properties of marine antimicrobial peptides by PEGylation
Authors: Lou Tong , Bai Xiuqin , He Xiaoyan , Liu Wencheng , Yang Zongcheng , Yang Ying , Yuan Chengqing
Published: January 2023

Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy. Similar to post-translational modifications of natural proteins, artificial modifications of antimicrobial peptides can introduce important impacts on their properties and functions. The present work revealed the enhanced effect of PEGylation on the antifouling properties of marine antimicrobial peptides (LWFYTMWH) through grafting the modified peptides on aluminium surfaces. PEG was coupled to the peptide by solid-phase peptide synthesis, and the PEGylated peptides were bioconjugated to the aluminium surfaces which was pre-treated by aryldiazonium salts to introduce carboxyl groups. The carboxy group has been activated through the reaction with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide. The successful modification was confirmed via FT-IR and XPS. Interestingly, the PEGylated peptides modified surfaces could kill 90.0% Escherichia coli (Gram-negative) and 76.1% Bacillus sp. (Gram-positive), and showed better antifouling performance than the original peptides modified surfaces. Furthermore, molecular dynamics simulations showed PEGylation could enhance the ability of peptides to destroy membrane. The PEGylated peptides inserted into the membrane and induced the change in local curvature of membrane, leading to the rupture of membrane. The presence of PEG changed the antimicrobial peptides into more flexible conformations and the high hydrophilicity of PEG hindered the settlement of bacteria. These might be the two main working mechanisms for the increased antifouling efficiency of PEGylated peptides modified surface. This study provided a feasible modification strategy of antimicrobial peptides to enhance their antifouling properties.
High-level production of pullulan and its biosynthesis regulation in Aureobasidium pullulans BL06
Authors: Chen Shuyu , Zheng Hongchen , Gao Jiaqi , Song Hui , Bai Wenqin
Published: January 2023

Pullulan has many potential applications in the food, pharmaceutical, cosmetic and environmental industries. However, the yield and molecular properties of pullulan produced by various strains still need to be promoted to fit the application needs. A novel yeast-like strain Aureobasidium pullulans BL06 producing high molecular weight (Mw) pullulan (3.3 × 106 Da) was isolated and identified in this study. The remarkable Mw of pullulan produced by A. pullulans BL06 was the highest level ever reported thus far. To further regulate the biosynthesis of pullulan in A. pullulans BL06, three gene knockout strains A. pullulans BL06 ΔPMAs, A. pullulans BL06 Δmel, and A. pullulans BL06 ΔPMAsΔmel, were constructed. The results showed that A. pullulans BL06 ΔPMAs could produce 140.2 g/L of moderate Mw (1.3 × 105 Da) pullulan after 120 h of fermentation. The highest yield level of pullulan to date could vastly reduce its production cost and expand its application scope and potential. The application experiments in food preservation showed that the moderate-Mw pullulan obtained in this work could reduce the weight loss of celery cabbages and mangos by 12.5% and 22%, respectively. Thus, the novel strains A. pullulans BL06 and A. pullulans BL06 ΔPMAs possessed unlimited development prospects in pullulan production at various Mw ranges and pullulan applications in multiple fields.
Nature inspiration, imitation, and emulation: Biomimicry thinking path to sustainability in the construction industry
Authors: Oguntona Olusegun Aanuoluwapo , Aigbavboa Clinton Ohis
Published: January 2023

The construction industry has been globally fingered as the major sector responsible for the continued deplorable state of the environment. The rising exploitation of the natural environment by the sector decapacitates the function of the flora and fauna to sustain life on earth. Therefore, the adoption and implementation of sustainability concepts in the construction industry are imperative to reduce the sector’s negative impacts on the environment. The growing field of biomimicry as a sustainability concept has increased global interest and call to maximize the numerous benefits offered by nature. This article is aimed at exploring biomimicry potentials in solving human challenges in a sustainable manner through responsible imitation, emulation, and drawing inspiration from nature. The first part of this paper explores the construction industry with rapt attention to its positive and negative impact on the human and natural environment. The second part provides a comprehensive overview of the biomimicry concept looking at its definitions, tenets, and sustainability standpoint. Finally, biomimicry inspiration, imitation, and emulation are discussed citing examples of their applications within and outside the built environment.
Distinct sets of olfactory receptors highly expressed in different human tissues evaluated by meta-transcriptome analysis: Association of OR10A6 in skin with keratinization
Authors: Nakanishi Shinobu , Tsutsui Taiki , Itai Nao , Denda Mitsuhiro
Published: January 2023

Olfactory receptors (ORs) are expressed in many tissues and have multiple functions. However, most studies have focused on individual ORs. Here, we aimed to conduct a comprehensive meta-transcriptome analysis of OR gene expression in human tissues by using open-source tools to search a large, publicly available genotype-tissue expression (GTEx) data set. Analysis of RNA-seq data from GTEx revealed that OR expression patterns were tissue-dependent, and we identified distinct sets of ORs that were highly expressed in 12 tissues, involving 97 ORs in total. Among them, OR5P2, OR5P3 and OR10A6 were associated with skin. We further examined the roles of these ORs in skin by performing weighted gene correlation network analysis (WGCNA) and c3net analysis. WGCNA suggested that the three ORs are involved in epidermal differentiation and water-impermeable barrier homeostasis, and OR10A6 showed the largest gene sub-network in the c3net network. Immunocytochemical examination of human skin keratinocytes revealed a sparse expression pattern of OR10A6, suggesting that it is not uniformly distributed among all keratinocytes. An OR10A6 agonist, 3-phenylpropyl propionate (3PPP), transiently increased intracellular Ca2+ concentration and increased cornified envelope (CE) production in cultured keratinocytes. Knock-down of OR10A6 diminished the effect of 3PPP. Overall, integration of meta-transcriptome analysis and functional analysis uncovered distinct expression patterns of ORs in various human tissues, providing basic data for future studies of the biological functions of highly expressed ORs in individual tissues. Our results further suggest that expression of OR10A6 in skin is related to epidermal differentiation, and OR10A6 may be a potential target for modulation of keratinization.
Immunological aspects of host–pathogen crosstalk in the co-pathogenesis of diabetes and latent tuberculosis
Authors: Verma Arpana , Kaur Maninder , Luthra Princy , Singh Lakshyaveer , Aggarwal Divya , Verma Indu , Radotra Bishan D. , Bhadada Sanjay Kumar , Sharma Sadhna
Published: January 2023

Introduction

Diabetes is a potent risk factor for the activation of latent tuberculosis and worsens the tuberculosis (TB) treatment outcome. The major reason for mortality and morbidity in diabetic patients is due to their increased susceptibility to TB. Thus, the study was conducted to understand the crosstalk between M. tuberculosis and its host upon latent tuberculosis infection and under hyperglycemic conditions or diabetes.

Methods

An animal model was employed to study the relationship between latent tuberculosis and diabetes. BCG immunization was done in mice before infection with M. tuberculosis, and latency was confirmed by bacillary load, histopathological changes in the lungs and gene expression of hspX, tgs1, tgs3 and tgs5. Diabetes was then induced by a single high dose of streptozotocin (150 mg/kg body weight). Host factors, like various cytokines and MMPs (Matrix metalloproteinases), which play an important role in the containment of mycobacterial infection were studied in vivo and in vitro.

Results

A murine model of latent TB was developed, which was confirmed by CFU counts (<104 in the lungs and spleen) and granuloma formation in lungs in the latent TB group. Also, the gene expression of hspX, tgs1, and tgs5 was upregulated, and after diabetes induction, blood glucose levels were >200 mg/dl. An in vitro study employing a THP-1 macrophage model of latent and active tuberculosis under normal and high glucose conditions showed that dormant bacilli were better contained in the presence of 5.5 mM glucose concentration as compared with active bacilli. However, the killing and restriction efficiency of macrophages decreased, and CFU counts increased significantly with an increase in glucose concentration.

Discussion

The decreased levels of MCP-1, decreased expression of mmp-9, and increased expression of mmp-1 in the latent group at high glucose concentrations could explain the failure of granuloma formation at high glucose conditions.
Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae
Authors: Wang Yanfei , Zhou Junxin , Liu Haiyang , Wang Qian , Zhang Ping , Zhu Jingyi , Zhao Dongdong , Wu Xueqing , Yu Yunsong , Jiang Yan
Published: January 2023

Colistin and tigecycline are usually regarded as the last resort for multidrug-resistant Klebsiella pneumoniae infection treatment. Emergence of colistin and tigecycline resistance poses a global healthcare challenge and is associated with high mortality due to limited therapeutic options. Here, we report the ST656 extensively drug-resistant K. pneumoniae strain KP15-652, which was isolated from a patient’s urine in China. Antimicrobial susceptibility testing showed it to be resistant to tigecycline, amikacin, levofloxacin, ciprofloxacin, and high-level colistin resistance (> 2048 mg/L). Whole-genome sequencing revealed that it harbors one chromosome and seven plasmids, including four plasmids carrying multiple acquired resistance genes. Transformation/conjugation tests and plasmid curing assays confirmed that mcr-1.1, mcr-8.2 and crrB mutations are responsible for the high-level colistin resistance and that a series of efflux pump genes, such as tmexCD1-toprJ1, tet(A) and tet(M), contribute to tigecycline resistance. mcr-1.1 and tet(M) are located on an IncX1 plasmid, which has conjugation transfer potential. mcr-8.2 and tet(A) are located on a multireplicon IncR/IncN plasmid but unable to be transferred via conjugation. Moreover, another conjugable and fusion plasmid carries the tmexCD1-toprJ1 gene cluster, which may have arisen due to IS26-mediated replicative transposition based on 8-bp target-site duplications. Importantly, a complex class 1 integron carrying various resistance genes was detected on this fusion plasmid. In conclusion, it is possible that the high-level of colistin resistance is caused by the accumulated effect of several factors on the chromosome and mcr-carrying plasmids, combined with many other resistances, including tigecycline. Effective surveillance should be performed to prevent further dissemination.
Cognitive decline among older adults with heart diseases before and during the COVID-19 pandemic: A longitudinal cohort study
Authors: Hua Rong , Li Chenglong , Gao Darui , Zheng Fanfan , Xie Wuxiang
Published: January 2023

Background

Little is known about the impact induced by the COVID-19 pandemic on the cognitive function of older adults with heart diseases. This study aimed to examine whether older adults with heart diseases suffered larger cognitive deterioration during the COVID-19 pandemic.

Methods

This study leveraged longitudinal data from the Health and Retirement Study (HRS), a nationally representative U.S. aging cohort with objective cognitive assessments measured before and during the pandemic. The interval from HRS waves 13 to 14 (April 2016 to June 2019) was defined as the pre-pandemic period to control the pre-existed cognitive difference between participants with and without heart diseases, and the interval from waves 14 to 15 (June 2019 to June 2021) was defined as the pandemic period. The HRS wave 14 survey was considered the baseline. The heart disease status was defined by a self-reported diagnosis. Linear mixed models were performed to evaluate and compare the cognitive differences during different periods.

Results

A total of 9,304 participants (women: 5,655, 60.8%; mean age: 65.8 ± 10.8 years) were included, and 2,119 (22.8%) had heart diseases. During the pre-pandemic period, there was no significant difference (−0.03, 95% CI: −0.22 to 0.15, P = 0.716) in the changes in global cognitive scores between participants with and without heart disease. During the pandemic period, a larger decreased change in the global cognitive score was observed in the heart disease group compared with the non-heart disease group (−0.37, 95% CI: −0.55 to −0.19, P < 0.001). An enlarged difference in global cognitive score was observed during the pandemic period (−0.33, 95% CI: −0.65 to −0.02, P = 0.036).

Conclusion

The findings demonstrated that the population with heart diseases suffered more cognitive decline related to the pandemic, underscoring the necessity to provide immediate cognitive monitoring and interventions for the population with heart diseases.
Risk factors for late reconnections after circumferential pulmonary vein isolation guided by lesion size index – Data from repeat invasive electrophysiology procedure
Authors: Mujović Nebojša M. , Marinković Milan M. , Marković Nebojša , Kocijančić Aleksandar , Kovačević Vladan , Vučićević Vera , Mujović Nataša M. , Potpara Tatjana S.
Published: January 2023

Background

Late reconnections (LR) of pulmonary veins (PVs) after wide antral circumferential ablation (WACA) using point-to-point radiofrequency (RF) ablation are common. Lesion size index (LSI) is a novel marker of lesion quality proposed by Ensite Precision mapping system, expected to improve PV isolation durability. This study aimed to assess the durability of LSI-guided PVI and the risk factors for LR of PVs.

Methods

The prospective study included 33 patients with paroxysmal atrial fibrillation (PAF) who underwent (1) the index LSI-guided WACA procedure (with target LSI of 5.5-6.0 for anterior and 5.0-5.5 for posterior WACA segments) and (2) the 3-month protocol-mandated re-mapping procedure in all patients, irrespective of AF recurrence after the index procedure. Ablation parameters reported by Ensite mapping system were collected retrospectively. The inter-lesion distance (ILD) between all adjacent WACA lesions was calculated off-line. Association between index ablation parameters and the LRs of PVs at 3 months was analyzed.

Results

The median patient age was 61 (IQR: 53–64) years and 55% of them were males. At index procedure, the first-pass WACA isolation rate was higher for the left PVs than the right PVs (64 vs. 33%, p = 0.014). In addition, a low acute reconnection rates were observed, as follows: in 12.1% of patients, in 6.1% of WACA circles, in 3.8% of WACA segments and in 4.5% of PVs. However, the 3-month remapping study revealed LR of PV in 63.6% of patients, 37.9% of WACA circles, 20.5% of WACA segments and 26.5% of PVs. The LRs were identified mostly along the left anterior WACA segment. Independent risk factors for the LR of WACA were left-sided WACA location (OR 3.216 [95%CI: 1.065–9.716], p = 0.038) and longer ILD (OR 1.256 [95%CI: 1.035–1.523] for each 1-mm increase, p = 0.021). The ILD of > 8.0 mm showed a predictive value for the LR of WACA, with the sensitivity of 84% and specificity of 46%. A single case of cardiac tamponade occurred following the re-mapping invasive procedure. No other complications were encountered.

Conclusion

Although the LSI-guided PVI ensures a consistent PVI during the index procedure, LRs of PVs are still common. Besides the LSI, the PVI durability requires an optimal ILD between adjacent lesions, especially along the anterior lateral ridge.
One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
Authors: Cherbi Miloud , Roubille François , Lamblin Nicolas , Bonello Laurent , Leurent Guillaume , Levy Bruno , Elbaz Meyer , Champion Sebastien , Lim Pascal , Schneider Francis , Cariou Alain , Khachab Hadi , Bourenne Jeremy , Seronde Marie-France , Schurtz Guillaume , Harbaoui Brahim , Vanzetto Gerald , Quentin Charlotte , Delabranche Xavier , Aissaoui Nadia , Combaret Nicolas , Tomasevic Danka , Marchandot Benjamin , Lattuca Benoit , Henry Patrick , Gerbaud Edouard , Bonnefoy Eric , Puymirat Etienne , Maury Philippe , Delmas Clément
Published: January 2023

Background

Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers  remains  unclear.  The  aim  of  this  study  was  to  evaluate  1-year  outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS.

Methods

FRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population.

Results

Within 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02).

Conclusion

VA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation.

Clinical trial registration

https://clinicaltrials.gov, identifier NCT02703038.
The genetic correlation and causal association between key factors that influence vascular calcification and cardiovascular disease incidence
Authors: Ni Xiaolin , Liu Lei , Yao Yao , Zhang Chi , Su Huabin , Lv Yuan , Li Rongqiao , Sun Liang , Zhou Qi , Zhu Xiaoquan , Yang Ze , Chen Zuoguan , He Wei , Zhu Huolan , Zhang Shenqi , Hu Caiyou , Yuan Huiping
Published: January 2023

Background

Serum calcium (Ca), vitamin D (VD), and vitamin K (VK) levels are key determinants of vascular calcification, which itself impacts cardiovascular disease (CVD) risk. The specific relationships between the levels of these different compounds and particular forms of CVD, however, remain to be fully defined.

Objective

This study was designed to explore the associations between these serum levels and CVDs with the goal of identifying natural interventions capable of controlling vascular calcification and thereby protecting against CVD pathogenesis, extending the healthy lifespan of at-risk individuals.

Methods

Linkage disequilibrium score (LDSC) regression and a two-sample Mendelian randomization (MR) framework were leveraged to systematically examine the causal interplay between these serum levels and nine forms of CVD, as well as longevity through the use of large publically accessible Genome-Wide Association Studies (GWAS) datasets. The optimal concentrations of serum Ca and VD to lower CVD risk were examined through a restrictive cubic spline (RCS) approach.

Results

After Bonferroni correction, the positive genetic correlations were observed between serum Ca levels and myocardial infarction (MI) (p = 1.356E–04), as well as coronary artery disease (CAD) (p = 3.601E–04). Negative genetic correlations were detected between levels of VD and CAD (p = 0.035), while elevated VK1 concentrations were causally associated with heart failure (HF) [odds ratios (OR) per 1-standard deviation (SD) increase: 1.044], large artery stroke (LAS) (OR per 1-SD increase: 1.172), and all stroke (AS) (OR per 1-SD increase: 1.041). Higher serum Ca concentrations (OR per 1-SD increase: 0.865) and VD levels (OR per 1-SD increase: 0.777) were causally associated with reduced odds of longevity. These findings remained consistent in sensitivity analyses, and serum Ca and VD concentrations of 2.376 mmol/L and 46.8 nmol/L, respectively, were associated with a lower CVD risk (p < 0.001).

Conclusion

Our findings support a genetic correlation between serum Ca and VD and CVD risk, and a causal relationship between VK1 levels and CVD risk. The optimal serum Ca (2.376 mmol/L) and VD levels (46.8 nmol/L) can reduce cardiovascular risk.
Construction applicability of mechanical methods for connecting aisle in the bohai mudstone stratum with high water pressure
Authors: Zhang Wencui , Li Yang , Dong Zibo , Yang Qiye
Published: January 2023

China’s traditional connecting aisle construction technology is mainly to combine soil reinforcement with mining excavation. The technology is relatively mature, but it has shortcomings such as long construction period and long-term construction settlement. In order to overcome the above shortcomings, mechanical methods for connecting aisle technology has become increasingly mature after years of research and development, and has been successfully applied in many areas. For the cross-sea tunnel project, this technology was first tried and applied in the interval tunnel of Qingdao Metro Line 8. It is challenging to construct the connecting aisle by mechanical method in Bohai mudstone stratum with high water pressure, which has the construction difficulties such as high excavation requirements, high requirements for post-support function and limited space of main tunnel. In this study, a cutter, propulsion system, and back supporting system were designed to handle the key and difficult points and risks of the aforementioned construction. Furthermore, targeted construction schemes were adopted for sleeve sealing, sleeve removal, and improvement of sleeve sealing. The applicability of the improved mechanical construction method to the geological conditions of the Qingdao area was verified through a numerical simulation. The research results can provide a reference for the mechanical construction of connecting aisle under similar formation conditions.
Groundwater potential zone mapping using geographic information systems and multi-influencing factors: A case study of the Kohat District, Khyber Pakhtunkhwa
Authors: Faheem Haris , Khattak Zeeshan , Islam Fakhrul , Ali Rashid , Khan Rehan , Khan Ilyas , Tag Eldin Elsayed
Published: January 2023

Groundwater is a vital component of life; without its identification, it is impossible to live. Therefore, identifying groundwater potential zones (GWPZs) is critical. For this purpose, the study area of the Kohat District was selected to identify GWPZs using the multi-influencing factors (MIF) approach. The Kohat area has a semi-arid to sub-humid subtropical climate and is classified as a sub-tropical, triple-season, semi-arid, sub-mountainous area. The geology, land use, soil, rainfall, lineament density, and drainage density are important parameters of ground water potential identification. The GWPZs were classified into five types: very poor, poor, good, high, and very high. We determined that 37.72% of the study area had high GWPZs, which were predominately in or near the northwest region of the study area, whereas 4.62% of the study area, in the southeast region, had very poor GWPZs. The water table data from the study varied due to different parameters used to identify the GWPZs. Our MIF results revealed that a large area of the Kohat District has good water potential. Still, due to topographic elevation changes, the groundwater potential has been limited in hilly areas. Our final results were compared with water level field data collected from different sources across the Kohat District.
The invasion law of drilling fluid along bedding fractures of shale
Authors: Li Hong , Wang Qing , Zhang Kun , Zhang Qing Hui , Song Tao , Zhang Chuang , Zhuo Lu Bin , Hao Chen , Feng Fu Ping , Wang He Yuan , Zhang Yin Quan
Published: January 2023

In the process of drilling, the drilling fluid will invade into the bedding plane of shale under the action of pressure difference that will cause hydration collapse and wellbore instability. In order to ensure the wellbore stability during shale oil and gas drilling, it is necessary to clarify the invasion law of drilling fluid along bedding fractures during the drilling process. The immersion experiment method is often used to study the invasion law of drilling fluid, which is quite different from the actual invasion process of drilling fluid underground. In this paper, the depth of drilling fluid invasion into shale under different confining pressures and displacement times is intuitively and accurately determined by the displacement experiment and NMR scanning first. Also, then the mathematical relationships between drilling fluid invasion depth and invasion time, invasion pressure difference, confining pressure, bedding angle, and drilling fluid viscosity were established. The errors between the calculated values of the drilling fluid invasion depth and the experimental values were less than 15%, and the calculation accuracy was high. In addition to the influence of invasion time, formation pressure difference and confining pressure on invasion depth were researched through the method of numerical simulation. The results showed that the liquid invasion depth increased logarithmically with the increase of invasion time and formation pressure difference, but it grew slowly in the later period and tended to be stable; the invasion depth decreased exponentially with the increase of confining pressure, bedding plane angle, and drilling fluid viscosity. The results in the paper provide a basis for the subsequent determination of the collapse pressure and collapse period of bedding shale.
Research on optimal coil configuration scheme of insulator relay WPT system
Authors: Wang Wei , Duan Mingrong , Zeng Zhenwei , Liu Huai , Ji Zhenya
Published: January 2023

This paper presents the optimized structure of the multi-relay coils insulator of WPT system. With the rapid development of the smart grid, on-line monitoring devices in the transmission tower have been widely used. However, the power supply problem has become an important bottleneck in the development of transmission tower intelligent sensing technology. Hence, the multi-relay coils wireless power transfer technology has been proposed to supply for the tower monitoring equipment in this paper. Compared with traditional multi-relay coils, the effects of the number, arrangement position and turns of relay coils on the performance of WPT system are further explored. The simulation results show that the operation performance of WPT can be significantly improved by optimizing the coil arrangement position and turns. Moreover, there are multiple configuration schemes that the design indexes of the system could be achieved. The experiment results show that in the 110 kV high-voltage transmission with the insulator length of 1.015 m, the transmitting power and efficiency of the WPT system could be increased to 1.81 W and 60.11% respectively by parameters optimization, which ensures the continuous and stable work of the monitoring equipment.
Tailor-made synaptic dynamics based on memristive devices
Authors: Bengel Christopher , Zhang Kaihua , Mohr Johannes , Ziegler Tobias , Wiefels Stefan , Waser Rainer , Wouters Dirk , Menzel Stephan
Published: January 2023

The proliferation of machine learning algorithms in everyday applications such as image recognition or language translation has increased the pressure to adapt underlying computing architectures towards these algorithms. Application specific integrated circuits (ASICs) such as the Tensor Processing Units by Google, Hanguang by Alibaba or Inferentia by Amazon Web Services were designed specifically for machine learning algorithms and have been able to outperform CPU based solutions by great margins during training and inference. As newer generations of chips allow handling of and computation on more and more data, the size of neural networks has dramatically increased, while the challenges they are trying to solve have become more complex. Neuromorphic computing tries to take inspiration from biological information processing systems, aiming to further improve the efficiency with which these networks can be trained or the inference can be performed. Enhancing neuromorphic computing architectures with memristive devices as non-volatile storage elements could potentially allow for even higher energy efficiencies. Their ability to mimic synaptic plasticity dynamics brings neuromorphic architectures closer to the biological role models. So far, memristive devices are mainly investigated for the emulation of the weights of neural networks during training and inference as their non-volatility would enable both processes in the same location without data transfer. In this paper, we explore realisations of different synapses build from memristive ReRAM devices, based on the Valence Change Mechanism. These synapses are the 1R synapse, the NR synapse and the 1T1R synapse. For the 1R synapse, we propose three dynamical regimes and explore their performance through different synapse criteria. For the NR synapse, we discuss how the same dynamical regimes can be addressed in a more reliable way. We also show experimental results measured on ZrOx devices to support our simulation based claims. For the 1T1R synapse, we explore the trade offs between the connection direction of the ReRAM device and the transistor. For all three synapse concepts we discuss the impact of device-to-device and cycle-to-cycle variability. Additionally, the impact of the stimulation mode on the observed behavior is discussed.
Impacts of stress hyperglycemia ratio on early neurological deterioration and functional outcome after endovascular treatment in patients with acute ischemic stroke
Authors: Dai Zheng , Cao Haiming , Wang Feng , Li Lei , Guo Hongquan , Zhang Xiaohao , Jiang Haichang , Zhu Juehua , Jiang Yongjun , Liu Dezhi , Xu Gelin
Published: January 2023

Background and Purpose

Hyperglycemia has been associated with unfavorable outcome of acute ischemic stroke, but this association has not been verified in patients with endovascular thrombectomy treatment. This study aimed to assess the impact of stress hyperglycemia ratio on early neurological deterioration and favorable outcome after thrombectomy in patients with acute ischemic stroke.

Methods

Stroke patients with endovascular thrombectomy in two comprehensive centers were enrolled. Early neurological deterioration was defined as ≥4 points increase of National Institutes of Health Stroke Scale (NIHSS) at 24 hours after endovascular procedure. Favorable outcome was defined as modified Rankin Scale (mRS) score of 0-2 at 90 days of stroke onset. Multivariate regression analysis was used to identify the predictors for early neurological deterioration and favorable outcome.

Results

Among the 559 enrolled, 74 (13.2%) patients developed early neurological deterioration. The predictors for early neurological deterioration were high stress hyperglycemia ratio at baseline (OR =5.77; 95% CI, 1.878-17.742; P =0.002), symptomatic intracranial hemorrhage (OR =4.90; 95% CI, 2.439-9.835; P <0.001) and high NIHSS score after 24 hours (OR =1.11; 95% CI, 1.071-1.151; P <0.001). The predictors for favorable outcome were stress hyperglycemia ratio (OR =0.196, 95% CI, 0.077-0.502; P =0.001), age (OR =0.942, 95% CI, 0.909-0.977; P =0.001), NIHSS score 24 hours after onset (OR =0.757, 95% CI =0.693-0.827; P <0.001), groin puncture to recanalization time (OR =0.987, 95% CI, 0.975-0.998; P =0.025), poor collateral status before treatment (ASITN/SIR grade 0-3, OR =62.017, 95% CI, 25.920-148.382; P <0.001), successful recanalization (mTICI 2b or 3, OR =7.415, 95% CI, 1.942-28.313; P =0.001).

Conclusion

High stress hyperglycemia ratio may be related to early neurological deterioration and decreased likelihood of favourable outcomes after endovascular thrombectomy in patients with acute ischemic stroke.
Short-term effect of polyethylene glycol loxenatide on weight loss in overweight or obese patients with type 2 diabetes: An open-label, parallel-arm, randomized, metformin-controlled trial
Authors: Cai Hongyu , Chen Qianqian , Duan Yale , Zhao Yue , Zhang Xiujuan
Published: January 2023

Objective

Polyethylene glycol loxenatide (PEG-Loxe) is a novel, once-weekly glucagon-like peptide 1 receptor agonist that is approved in doses of 0.1 mg and 0.2 mg for the treatment of type 2 diabetes mellitus (T2DM). However, no clinical trials have been designed to determine the effect of 0.3 mg PEG-Loxe on weight loss in overweight or obese patients with T2DM. This trial aimed to evaluate the short-term effect of 0.3 mg PEG-Loxe, injected subcutaneously once weekly, for weight management in overweight or obese patients with T2DM.

Methods

This 16-week, open-label, parallel-arm, randomized, metformin-controlled trial was conducted at Shandong Provincial Hospital in Shandong, China. Patients with T2DM, who were overweight or obese (body mass index ≥ 25.0 kg/m2) and had been treated with lifestyle interventions or a combination with oral antidiabetic drug monotherapy were randomized (2:1) to receive 0.3 mg PEG-Loxe or 1500 mg metformin. The primary endpoint was a change in body weight from baseline to week 16.

Results

Overall, 156 patients were randomized and exposed to treatment. Weight loss was 7.52 kg (8.37%) with PEG-Loxe and 2.96 kg (3.00%) with metformin, with a between-group difference of 4.55 kg (95% CI, 3.43 to 5.67) (P < 0.001). A significantly higher proportion of patients lost ≥5% (61.5% vs. 25.0%) or 10% (26.9% vs. 5.8%) body weight in the PEG-Loxe group than in the metformin group (P < 0.01). Additionally, PEG-Loxe resulted in marked improvements in several cardiovascular risk factors compared to metformin, including body mass index, waist circumference, visceral fat area, blood pressure, and lipid profile. PEG-Loxe and metformin displayed almost equal potency for glycemic control. The incidence of adverse events was 46.2% (48/104) and 44.2% (23/52) in the PEG-Loxe and metformin groups, respectively.

Conclusion

In overweight or obese patients with T2DM, a once-weekly subcutaneous administration of PEG-Loxe for 16 weeks, in addition to lifestyle interventions or oral antidiabetic drug therapy, resulted in significantly greater weight loss compared to metformin. Additional trials are necessary to establish whether these effects can be maintained in the long term.

Clinical trial registration

www.chictr.org.cn, identifier ChiCTR2200057800.
Characterization of a novel corticosterone response gene in Xenopus tropicalis tadpole tails
Authors: Paul Bidisha , Dockery Rejenae , Valverde Valery M. , Buchholz Daniel R.
Published: January 2023

Corticosteroids are critical for development and for mediating stress responses across diverse vertebrate taxa. Study of frog metamorphosis has made significant breakthroughs in our understanding of corticosteroid signaling during development in non-mammalian vertebrate species. However, lack of adequate corticosterone (CORT) response genes in tadpoles make identification and quantification of CORT responses challenging. Here, we characterized a CORT-response gene frzb (frizzled related protein) previously identified in Xenopus tropicalis tadpole tail skin by an RNA-seq study. We validated the RNA-seq results that CORT and not thyroid hormone induces frzb in the tails using quantitative PCR. Further, maximum frzb expression was achieved by 100-250 nM CORT within 12-24 hours. frzb is not significantly induced in the liver and brain in response to 100 nM CORT. We also found no change in frzb expression across natural metamorphosis when endogenous CORT levels peak. Surprisingly, frzb is only induced by CORT in X. tropicalis tails and not in Xenopus laevis tails. The exact downstream function of increased frzb expression in tails in response to CORT is not known, but the specificity of hormone response and its high mRNA expression levels in the tail render frzb a useful marker of exogenous CORT-response independent of thyroid hormone for exogenous hormone treatments and in-vivo endocrine disruption studies.
Lightweight and dynamic authenticated key agreement and management protocol for smart grid
Authors: Zhai Feng , Yang Ting , Sun Wei , Fang Xu
Published: January 2023

With the development of IoT and 5G, the smart grid, as one of the key component for the smart city, can provide the uninterrupted and reliable electricity service by properly adjusting the electricity supply according to the consumption of users. The advanced metering infrastructure (AMI), as an important part of smart grid system, is a complete network and system for measuring, collecting, storing and analyzing the electricity consumption information of users. The security of AMI plays a vital role in the smooth operation of smart grid. In this paper, we study how to establish the secure communication between two entities in AMI, namely the smart meter and the electricity service provider. Although, there are many authentication and key management protocols for AMI, the high complexity and computation overhead of these protocols hinder their application in the smart grid environment. Based on identity cryptosystem and elliptic curve cryptography (ECC), we put forward a lightweight and dynamic authenticated key agreement and management protocol, which can significantly reduce the computation overhead of the resource-constrained smart meters. In addition, we utilize a one-way key tree technique to efficiently generate and update the group key in the multicast communication. We give a systematic proof to show that our designed protocol not only guarantees the confidentiality and integrity of transmitted messages, but also resists various attacks from an adversary. Finally, we carry out some simulated experiments to demonstrate the high efficiency of our designed protocol.