bluuebunny/crossref_metadata_2025 huggingface dataset:
ПІДГОТОВКА МАЙБУТНІХ УЧИТЕЛІВ УКРАЇНСЬКОЇ МОВИ І ЛІТЕРАТУРИ ДО НАВЧАННЯ УЧНІВ У НУШ
Authors: Семеног Олена Миколаївна , Дятленко Тетяна Іванівна , Калинич Олеся Василівна
Published: February 2024

У статті окреслено змістове та методичне забезпечення підготовки майбутніх учителів української мови і літератури до навчання учнів у НУШ. Акцентовано увагу на питаннях якості шкільної мовної освіти в умовах воєнного стану, особливостях реалізації Концепції Нової української школи, основна риса якої – формувати оновлені знання й уміння застосовувати їх у реальних ситуаціях, життєвих та професійних ситуаціях, формувати ставлення на основі цінностей. Зазначено, що створення сучасного освітнього середовища, впровадження в освітній процес НУШ інноваційних технологій та засобів навчання Концепції зумовлює оновлення підходів та осучаснення змісту професійної, методичної підготовки майбутніх учителів української мови і літератури до навчання учнів у НУШ у закладах вищої освіти. Окреслено оновлені освітні програми підготовки майбутніх учителів української мови і літератури, що має міждисциплінарну та соціонімічну спрямованість, зорієнтована на сучасні наукові досягнення в галузі філології, педагогіки, методики викладання мови і літератури; враховує специфіку роботи вчителя української мови й літератури, який володіє фундаментальними знаннями й відповідними компетентностями в галузі педагогіки, психології, методики середньої освіти; здатний на високому професійному рівні забезпечувати компетентнісне навчання української мови, літератури та вирішувати завдання у професійній сфері, що характеризуються невизначеністю та комплексністю умов. Окреслено оновлену робочу програму мовно-методичної підготовки майбутніх учителів української мови і літератури на засадах компетентнісного підходу, зокрема предметно-методичну компетентність як здатність: застосовувати поглиблені знання з теорії української мови, української літератури для вирішення професійних завдань, подавати власну інтерпретацію літературних (мовних) явищ; застосовувати когнітивно-дискурсивні вміння у створенні зв’язних монологічних і діалогічних текстів в усній і писемній формах; застосовувати у продукуванні текстів різностильові та різножанрові одиниці з урахуванням комунікативної ситуації та комунікативного завдання; моделювати зміст навчання з української мови і літератури; формувати предметну і ключові компетентності й наскрізні вміння, ціннісні ставлення відповідно до обов’язкових результатів навчання учнів; добирати, використовувати, створювати ефективні методики й технології навчання, виховання і розвитку учнів; застосовувати, вдосконалювати, створювати доцільне дидактичне забезпечення освітнього процесу з урахуванням специфіки технологій електронного, мобільного й змішаного навчання. На прикладі занять з курсу методики навчання української мови в закладах загальної середньої освіти продемонстровано вправи, які допоможуть урізноманітнити освітній процес з української мови і зробити його сучасним.
Chapada do Araripe/Brasil: estrategías de internacionalización del currículo y educación ambiental
Authors:   Universidad de Vale do Rio dos Sinos, Costa Alves Suiane , Viana Freires Eduardo ,   Secretaría de Educación del Estado de Ceará
Published: February 2024

El presente trabajo tiene por objetivo reflexionar acerca de la internacionalización del currículo en la promoción de la sustentabilidad. Metodológicamente, se desarrolló una investigación bibliográfica a partir de la Chapada do Araripe, buscando en las principales bases de datos fundamentar las reflexiones propuestas. Con base en los resultados se observó la importancia del ecosistema que posee como evidencia el testimonio de faunas y floras. Reconocida internacionalmente por su contenido fosilífero e inestimable valor científico, propone la elaboración de acciones estratégicas en colaboración com el espacio acadêmico para el empoderamiento de los ciudadanos, estimulando el protagonismo estudiantil en los diversos espacios para el exercicio de la ciudadanía glob
El método fenomenológico en la investigación educativa: entendiendo los principios clave de la metodología de Max van Manen
Authors:   Universidad Autónoma de Puebla, Montes Sosa José Gabriel , Castillo Sanguino Narciso ,   Universidad Tecnológica de Izúcar de Matamoros
Published: February 2024

La fenomenología hace referencia a un movimiento filosófico y a diversas perspectivas de investigación cualitativa. La propuesta del pedagogo Max van Manen es una propuesta de investigación fenomenológica con características propias y que resulta difícil de aprehender para los investigadores cualitativos que recién se interesan en ella. El presente texto tiene por objetivo describir los principios y los supuestos metodológicos de la fenomenología hermenéutica, también llamada fenomenología de la práctica, que no han sido difundidos de manera explícita en la literatura, lo cual dificulta la comprensión de este método. El artículo se divide en dos secciones principales, en la primera sección se describe el principio teleológico, el principio ontológico y el principio epistemológico. En la segunda sección se describen los supuestos metodológicos que incluyen la metodología al servicio de la práctica profesional, transitar de la actitud natural a la actitud fenomenológica, investigar la experiencia tal como es vivida, la experiencia vivida no puede conocerse a través de código ni categorías y el texto fenomenológico promueve el conocimiento pático. Se concluye que la fenomenología de la práctica es una metodología cualitativa fenomenológica no canónica, que investiga el fenómeno educativo tal como es vivido (principio ontológico), que promueve la adquisición de una sabiduría práctica (principio epistemológico) y que permite velar por el bienestar de los estudiantes (principio teleológ
Understanding Robinson Crusoe’s Place in the Literature and Culture of Childhood
Authors: O'Malley Andrew
Published: February 2024

[para. 1]: “Robinson Crusoe has left a remarkable three-centuries long legacy. The novel was, from its initial publication in1719, wildly successful, with some forty editions appearing before the end of the eighteenth century. Translations into French, German, and Dutch appeared within a year, and it would go on to place second only to the Bible as the most widely translated literary work in publishing history. Crusoe’s story has also been retold and remediated into more forms and media than perhaps any other work of fiction. Literary imitations grew so common that they quickly became a sub-genre, the ‘Robinsonade’, a term coined by Johann Gottfried Schnabel to describe his own early example of the form, Die Insel Felsenburg (1731). A variety of abridged versions and epitomes, selling for half the price of the first edition or less, were on the market by the early 1720s, and as Jordan Howell remarks, these would prove more popular than the original, complete text, accounting for roughly three quarters of the hundreds of editions published during the eighteenth century.”
Introduction: Eighteenth-Century Childhoods and Literary Cultures
Authors: O'Malley Andrew
Published: February 2024

[para. 1]: “The eighteenth century has long been regarded as a watershed period in the history of both childhood and children’s literature. It saw the rapid growth of a specialized text industry addressing young readers, and at the same time, the child became increasingly visible and important in a range of ‘adult’ discourses. Philippe Ariès’s now more than a half-century-old assertion that the child, as differentiated subject with its own needs and material culture, did not exist in Europe before the seventeenth century has rightly and usefully been critiqued, as has J.H. Plumb’s famous celebration of a ‘new world of children’ in the eighteenth century.3 Yet the fact remains that, certainly and most notably within the more privileged segments of English society, experiences of childhood for many changed significantly in the period this volume considers, as did the ways in—and extent to—which the child circulated within literary culture.”
Pengaruh Pemberian Pupuk Organik Cair Berbasis Kulit Buah terhadap Pertumbuhan Bayam Brasil (Althernanthera sissoo hort) dalam Sistem Hidroponik
Authors: Kurnianto Hizkia Andrian , Limeranto Desyana Millenia , Madyaningrana Kukuh
Published: February 2024

Kulit buah merupakan jenis limbah organik yang banyak dihasilkan dari konsumsi buah harian masyarakat untuk memenuhi kebutuhan nutrisi. Limbah berupa kulit buah mengandung beragam nutrien yang bisa dimanfaatkan sebagai bahan baku pembuatan pupuk organik cair (POC). Penelitian ini bertujuan untuk mempelajari dampak pemberian POC berbasis kulit buah terhadap pertumbuhan tanaman bayam Brasil (Althernanthera sissoo hort) dalam sistem hidroponik. Penelitian didesain dengan 5 perlakuan berupa perlakuan K0 (tanpa pupuk), K1 (AB-Mix 500 ppm), P1 (POC 250 ppm), P2 (POC 500 ppm), dan P3 (POC 750 ppm) dengan tiap perlakuan mempunyai 5 ulangan. Data penelitian yang menjadi target adalah kandungan karbon (C-organik), nitrogen (N), fosfor (P), dan kalium (K) POC berbasis kulit buah, dan pertumbuhan bayam Brasil meliputi tinggi tanaman, jumlah daun, lebar daun, panjang akar, berat basah, dan berat kering. Uji one-way ANOVA digunakan dalam analisis data penelitian. Hasil penelitian menunjukkan bahwa kadar C-organik dan total NPK POC berbasis kulit buah masih dibawah standar POC yang ditetapkan Kementerian Pertanian. Meskipun pertumbuhan bayam Brasil yang diberi POC kulit buah masih dibawah pertumbuhan tanaman yang dipupuk dengan AB-Mix, beberapa variasi dosis POC kulit buah menunjukkan hasil yang menunjang pertumbuhan bayam Brasil. Dosis 250 ppm berpengaruh terhadap pertambahan tinggi tanaman, jumlah daun, lebar daun dan panjang akar; sedangkan dosis 500 ppm menunjang pertambahan berat basah dan berat kering bayam Brasil.
Keanekaragaman dan Peran Ekologis Serangga Tanah di Kawasan Hutan Rafae Kecamatan Raimanuk Kabupaten Belu
Authors: Tae Valerian Yunito , Seran Yoseph Nahak , Bani Polikarpia Wilhelmina
Published: February 2024

Serangga tanah merupakan jenis dari serangga yang seluruh atau sebagian hidupnya ditemukan di permukaan tanah. Berdasarkan tingkat trofiknya serangga dibagi menjadi 3 jenis yaitu, serangga herbivora, serangga karnivora dan serangga dekomposer. Penelitian ini bertujuan untuk mengetahui : Untuk menganalisis jenis serangga tanah yang terdapat di Kawasan hutan Rafae Kecamatan Raimanuk   Kabupaten Belu, Untuk menganalisis Bagaimana indeks keanekaragaman serangga di Kawasan hutan Rafae Kecamatan Raimanuk  Kabupaten Belu Penelitian dilakukan pada bulan September – November 2022. Penelitian ini bersifat deskriptif-eksploratif. Metode yang digunakan pada penelitian ini yaitu metode Pitffall trap. Hasil penelitian yang di dapat Pada Kawasan Hutan Rafae Kecamatan Raimanuk Kabupaten Belu Ditemukan 14 jenis serangga tanah yang terdiri dari 11 famili serangga dan 5 ordo dengan jumlah individu 364 jenis serangga, dari 12 perangkap yang di pasang pada 2 plot. Spesies serangga tanah yang ditemukan terdapat spesies serangga tanah yang berperan sebagai polinator, dekomposer, predator, parasitoid dan bioindikator.
PELESTARIAN KAWASAN SITUS BERSEJARAH MASJID GAMPONG TEUNGOH, KECAMATAN LANGSA KOTA, KOTA LANGSA
Authors: Amelia Mentari
Published: February 2024

Pelestarian kawasan situs bersejarah masjid Gampong Teungoh, Kecamatan Langsa Kota, Kota Langsa, merupakan suatu peninggalan situs cagar budaya dimana situs cagar tersebut berbentuk bangunan Masjid yang di beri nama masjid Istiqomah, Masjid Istiqomah sendiri di bangun pada tahun1323H, atau tahun 1901M, dengan luas bangunan 11x11 yang dimana diprakarsai oleh Teuku Banta berdan , Masjid Istiqomah sendiri memiliki suatu peninggalan sejarah yang dimana masjid tesebut adalah masjid yang pertama kali berdiri ataupun yang di bangun di Kota Langsa, Masjid tertua yang ada di Kota langsa yang dimana merupakan sebagai saksi sebagai penyebaran Islam di Kota Langsa dan juga merupakan masjid yang pertama kali ada di Kota langsa pada zaman dahulu. .Tujuan penelitian ini adalah untuk mengetahui potensi kawasan bersejarah Masjid Gampong Teungoh dan penulisn juga bertujuan untuk mengetahui sejauh mana pelestarian kawasan situs bersejarah Masjid Gampomg Teugoh.Adapun metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif, yaitu penelitian yang bersifat pada kata- kata atau data dan gambaran pada suatu llingkungan tertentu yang langsung menjadikan sebuah llingkungan dilapangan sebagai fokus utama, selain itu penelitian ini lebih menonjolkan pada sebuah proses yang dan makna yang terjadi dalam sebuah lingkungan.Hasil dari penelitian yang penulis dapat ialah kawasan situs cagar budaya seperti Masjid Istiqomah Gampong Teungoh dimana salah satu situs cagar budaya yang terdapat di Kota Langsa dan dimana bengunan ini ialah bangunan Masjid yang pertama kali ada di Kota langsa sehingga bangunan ini dapat berfungsi dengan baik, dan juga potensi ataupun perkembangan yang terjadi ialah dimana bangunancagar budaya ini dapat menjadikan suatu bangunan situs sejarah dapat memberikan suatu aspek pembelajaran terhadap pelajar dan juga terhadap masyarakat mengenai kawasan bersejarah dan juga seberapa pengaruhnya masjid terhadap perkembangan islam khususnya di Kota Langsa.Penulis juga menyarankan kepada pemerintah dan juga kepada masyarakat khususnya masyarakat Gampong Teungoh agar dapat menjaga keutuhan masjid istiqomah dan juga dapat melakukan perawatan sehingga masjid tersebut dapat menjadikan suatu potensi kawasan bersejarah dan dapat melakukan pelesatarian dengan sangat baik.
Hemostasis and endothelial functionality: the double face of coagulation factors
Authors: Olgasi Cristina , Assanelli Simone , Cucci Alessia , Follenzi Antonia
Published: February 2024

Hemostasis is a sophisticated sequence of events aimed to repair vessel injury. This process occurs in combination with angiogenesis, which leads to new blood vessel formation helping in the wound repair and facilitating tissue healing. The fine mechanisms that regulate hemostasis and angiogenesis are well described, but for long time, coagulation factors (CFs) have been considered merely players in the coagulation cascade. However, several experimental evidences highlight the crucial functions of these CFs in regulating endothelial functionality, especially in the angiogenic process. Some of these CFs (e.g. thrombin and tissue factor) have been widely investigated and have been described to trigger intracellular signaling related to endothelial cell (EC) functionality. For others (e.g. factor VIII and thrombomodulin), potential receptors and molecular mechanisms have not been fully elucidated but some data show their potential to induce EC response. This review focuses on the emerging roles of selected CFs in regulating EC functions, especially highlighting their ability to activate signaling pathways involved in the angiogenesis, migration, proliferation and endothelial barrier stability.
Adjusting for subsequent therapies in the TOURMALINE-MM1 study shows clinically meaningful improvement in overall survival with addition of ixazomib to lenalidomide and dexamethasone
Authors: Ramasamy Karthik , Bahlis Nizar J. , Kumar Shaji K. , Kumar Arun , Cranmer Holly , Wang Bingxia , Dabora Jonathan , Labotka Richard , Richardson Paul G. , Moreau Philippe
Published: February 2024

TOURMALINE-MM1, the only blinded randomized study in patients with relapsed and/or refractory multiple myeloma (RRMM; ≥1 prior therapy) in the last 10 years, investigated ixazomib+lenalidomide+dexamethasone (IRd) versus lenalidomide+dexamethasone (Rd). Final overall survival (OS) data were based on a median follow-up of 85 months. In RRMM trials where patients have had 1-3 relapses after initial treatment, a high proportion receive subsequent therapy. Application of salvage therapies in blinded trials and newer modes of therapy can increasingly complicate the interpretation of OS. This analysis explores the impact of subsequent therapies on OS outcomes in TOURMALINE-MM1.
The inverse probability of censoring weights (IPCW) method, marginal structural model (MSM), and rank preserving structural failure time model (RPSFTM) were utilized to adjust for confounding on OS, introduced by subsequent therapies. Analyses were conducted for the intentto-treat (ITT) population and ≥2 prior lines subgroup.
Unadjusted hazard ratio (HR) for IRd versus Rd was 0.94 (95% confidence interval [CI]: 0.78-1.13) in the ITT population. After adjusting for the impact of subsequent therapies by the RPSFTM method, estimated HR for IRd versus Rd in the ITT population was 0.89 (95% CI: 0.74-1.07). Adjusting with IPCW and MSM methods also showed an improvement in HR, favoring IRd. IRd may be particularly beneficial in patients with ≥2 prior lines of therapy (IPCW and MSM HR=0.52, 95% CI: 0.30-0.88; RPSFTM HR=0.68, 95% CI: 0.51-0.91).
These analyses highlight the growing challenge of demonstrating OS benefit in multiple myeloma patients and the importance of assessing confounding introduced by subsequent therapies when interpreting OS.
Modeling arithmetic systems of elliptic curve cryptography using Microsoft Excel VBA
Authors: Syamsuddin I , Syafaruddin S
Published: February 2024

Purpose. This study aims to develop a new teaching module to illustrate the arithmetic systems of Elliptic Curve Cryptography, a powerful yet simple algorithm for information security, by exploring the capability of the Visual Basic Applications of Microsoft Excel in user friendly way. Methodology. The research is performed using research and development approach, which is divided into five steps utilizing VBA features of Microsoft Excel. It starts with modeling arithmetic in Microsoft Excel spreadsheet, then testing the validity through calculation and setup of the actual arithmetic of Elliptic Curve Cryptography using VBA Excel, before performing the test of the VBA application and finally visualizes the results in graphical mode. Findings. Novel teaching software based on of Microsoft Excel Visual Basic Applications is produced that is able to simulate arithmetic system behind Elliptic Curve Cryptography in an easy way for students. Originality. To the best of the authors’ knowledge, this is the first simulation based on Excel VBA to illustrate the arithmetic systems of Elliptic Curve Cryptography for teaching purposes. Practical value. In general, mastering cryptography will need a steep learning curve; however, using Microsoft Excel as a simulation platform will accelerate learning. The main practical value is the ease of Microsoft Excel, which will turn cryptography learning which was commonly very difficult for student to become easier and user friendly.
Medium and Long-Term Data from a Series of 96 Endoscopic Transsphenoidal Surgeries for Cushing Disease
Authors: Erkan Buruç , Bayındır Muhammed , Akpınar Ebubekir , Tanrıverdi Osman , Haşimoğlu Ozan , Postalcı Lütfi Şinasi , Bugün Didem Acarer , Tekin Dilara , Çiftçi Sema , Çakır İlkay , Mert Meral , Günaldı Ömür , Hatipoğlu Esra
Published: February 2024

Objective : Postoperative data on Cushing’s disease (CD) are equivocal in the literature. These discrepancies may be attributed to different series with different criteria for remission and variable follow-up durations. Additional data from experienced centers may address these discrepancies. In this study, we present the results obtained from 96 endoscopic transsphenoidal surgeries (ETSSs) for CD conducted in a well-experienced center.Methods : Pre- and postoperative data of 96 ETSS in 87 patients with CD were included. All cases were handled by the same neurosurgical team between 2014 and 2022. We obtained data on remission status 3−6 months postoperatively (medium-term) and during the latest follow-up (long-term). Additionally, magnetic resonance imaging (MRI) and pathology results were obtained for each case.Results : The mean follow-up duration was 39.5±3.2 months. Medium and long-term remission rates were 77% and 82%, respectively. When only first-time operations were considered, the medium- and long-term remission rates were 78% and 82%, respectively. The recurrence rate in this series was 2.5%. Patients who showed remission between 3−6 months had higher longterm remission rates than did those without initial remission. Tumors >2 cm and extended tumor invasion of the cavernous sinus (Knosp 4) were associated with lower postoperative remission rates.Conclusion : Adenoma size and the presence/absence of cavernous sinus invasion on preopera-tive MRI may predict long-term postoperative remission. A tumor size of 2 cm may be a supporting criterion for predicting remission in Knosp 4 tumors. Further studies with larger patient populations are necessary to support this finding.
Особенности подъема неньютоновских жидкостей в пористом материале
Authors: Нахай Дмитрий Михайлович , Байков Валентин Иванович , Миканович Дмитрий Станиславович
Published: February 2024

Цель. Изучение особенностей подъема полимерных растворов разной концентрации в пористом материале.
Методы. Экспериментальный метод исследования с использованием математических методов обработки результатов измерений.
Результаты. Выявлено, что интенсивность насыщения пористого материала растворами полиакриламида значительно снижалась после первых 30 с эксперимента. Кроме того, скорость насыщения пористого материала уменьшалась с увеличением концентрации полиакриламида в растворе. В отличие от дистиллированной воды растворы полиакриламида продолжали подниматься до полного насыщения пористого материала, что указывает на возможное присутствие пристенного эффекта скольжения.
Область применения исследований. Полученные результаты важны для дальнейшего исследования поведения полимерных растворов, применяемых на промышленных объектах.
The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection
Authors: Cai Yu Chun , Yang Chun Li , Song Peng , Chen Muxin , Chen Jia Xu
Published: February 2024

The intracellular parasite Babesia microti is among the most significant species causing human babesiosis and is an emerging threat to human health worldwide. Unravelling the pathogenic molecular mechanisms of babesiosis is crucial in developing new diagnostic and preventive methods. This study assessed how priming with B. microti surface antigen 1 (BHSA 1) and seroreactive antigen 5-1-1 (BHSA 5-1-1) mediate protection against B. microti infection. The results showed that 500 µg/ml rBMSA1 and rBMSA5-1-1 partially inhibited the invasion of B. microti in vitro by 42.0 ± 3.0%, and 48.0 ± 2.1%, respectively. Blood smears revealed that peak infection at 7 days post-infection (dpi) was 19.6%, 24.7%, and 46.7% in the rBMSA1, rBmSA5-1-1, compared to the control groups (healthy mice infected with B. microti only), respectively. Routine blood tests showed higher white blood cell, red blood cell counts, and haemoglobin levels in the 2 groups (BMSA1 and BMSA5 5-1-1) than in the infection control group at 0–28 dpi. Moreover, the 2 groups had higher serum interferon-γ, tumor necrosis factor-α and Interleukin-17A levels, and lower IL-10 levels than the infection control group throughout the study. These 2 potential vaccine candidate proteins partially inhibit in vitro and in vivo B. microti infection and enhance host immunological response against B. microti infection.
HERBAL LEAF CLASSIFICATION USING DEEP LEARNING MODEL EFFICIENTNETV2B0
Authors: Putra Rakha Pradana Susilo , Aditya Christian Sri Kusuma , Wicaksono Galih Wasis
Published: February 2024

Science regarding plants has experienced significant progress, especially in the study of medicinal plants. Medicinal plants have been used in medicine and are still an important component in the world of health today. Among the various parts of the plant, the leaves are also one that can be used as medicine. However, not many people can recognize these herbal leaves directly. This is because the herbal leaves at first glance look almost the same, so it is difficult to differentiate them. The aim of this research is to classify herbal leaf images by identifying the structural features of the leaf images. The dataset in this study uses 10 classes of leaf images, namely, starfruit, guava, lime, basil, aloe vera, jackfruit, pandan, papaya, celery, and betel, where each class uses 350 images with a total of 3500 images of data. The EfficientNetV2B0 model was chosen because it has a minimalist architecture but has high effectiveness. Based on the results of research using the EffiecientNetV2B0 model, the accuracy was 99.14% and the loss value was 1.95% using test data.
Liquid biopsies in pediatric rhabdomyosarcoma and beyond
Authors:   , Lak Nathalie Saskia Marguerite
Published: February 2024

In the Netherlands, more than 500 children are diagnosed each year with a pediatric malignancy, of which 33% with a solid tumor. Treatment for these solid tumors is intensive and has a great impact on quality of life. Additionally, it is hard to identify patients upfront with therapy resistant disease which can lead to recurrent disease and is associated to high mortality. Currently, treatment stratification and response monitoring is based on analysis of tumor material and imaging studies, which can be a burden for the patients and have limited sensitivity. Minimally invasive sampling of blood to detect circulating tumor material using molecular analysis, i.e. liquid biopsies, can form an additional modality to improve current risk stratification at diagnosis and response monitoring during treatment. In the first part of this thesis, we demonstrated that presence of tumor-specific material in small volumes of blood from patients with rhabdomyosarcoma (tumor of the muscles) can predict clinical outcome. Furthermore, we showed that it is feasible to design patient-specific assays suitable for clinical application and different liquid biopsy-based techniques can be complementary. In the second part of this thesis, we also investigated further novel molecular techniques for liquid biopsy analysis of patients with different types of solid tumors, such as neuroblastoma and Ewing sarcoma.
In conclusion, analysis of liquid biopsies can be of added value to current clinical methods and ultimately help to improve outcome for children with solid tumors.
Testicular Angiomyolipoma: A Case Report and Review of the Literature
Authors: Altan Sukru Ali , Karaman Zuhre Selma , Adsan Oztug
Published: February 2024

Angiomyolipoma (AML) is a benign mesenchymal tumor, that is composed of thick-walled blood vessels, smooth muscle cells and adipose tissue. They are commonly seen in kidneys, testicles are not a typical location for AML’s; many solid testicular tumors are germ cell malignancies. Here we report the sixth testicular AML case in the literature, to our knowledge. An 80-year-old male undergone bilateral orchiectomy with the diagnosis of local invasive prostate cancer, without any testicular symptoms. Pathological analysis demonstrated a tumor, involving nearly the whole left testicle, composed of muscle cells, vessels and fat tissue, diagnosed as testicular AML. In this article our case is reported and we also make a literature review about testicular AML’s.
Spontaneous Urethrocutaneous Fistula in Child with Spastic Cerebral Palsy: A Case Report
Authors: Kilic Sinan , Verep Samed
Published: February 2024

Urethrocutaneous fistulas are complications that usually seen after hypospadias repair. Spontaneous urethrocutaneous fistulas are extremely rare disorders unless related to the surgery of hypospadias. These fistulas are not associated with hypospadias repair, infection and trauma. While there are few cases reported in adults, there are no cases reported in children. Urethrocutaneous fistulas may rarely be encountered post-trauma, infection or due to weakness of spongious tissue of penis as well as. Children with spastic cerebral palsy often face various problems due to prolonged hospitalizations. Pressure ulcers are among the most common of these issues. Urinary catheterization is frequently performed in these patients for urine monitoring. A 6-year-old male patient with cerebral palsy developed a urethrocutaneous fistula while being monitored in the pediatric intensive care unit. Pre-existing unnoticed partial prepuce and weakness in the corpus spongiosum were present in the patient. We suspect that the development of the urethrocutaneous fistula is attributed to frequent urethral catheterization and the development of decubitus ulcer in the penile region. Since a similar case is not found in the pediatric literature, our aim is to present this case for reference.
PENERAPAN METODE FUZZY MAMDANI TERHADAP TINGKAT KEPUASAN PELANGGAN BERDASARKAN HARGA DAN KUALITAS PELAYANA
Authors: Septiawati Anggita , Arman  , Muhtar Norma , Somayasa Wayan , Alfian
Published: February 2024

Pada penelitian ini dibahas mengenai tingkat kepuasan pelanggan yang dibuat dalam metode fuzzy mamdani. Kepuasaan pelanggan menjadi salah satu faktor terpenting dalam dunia pebisnis sehingga kepuasan pelanggan menjadi tolak ukur yang harus diperioritaskan oleh pelaku pebisnis. Untuk mengukur kepuasan pelanggan terdapat berbagai hal yang harus diperhatikan tidak hanya dari segi rasa, kualitas pelayanan dan harga juga sangat berpengaruh terhadap tingkat kepuasan pelanggan, sehingga untuk tingkat kepuasan pelanggan di Warkop Kopi Kita  menggunakan metode fuzzy mamdani dan dibantu dengan Microsofft Office Ecsel. Untuk mendapatkan nilai output dilakukan dalam beberapa tahap yaitu: pembentukan himpunan fuzzy, menentukan fungsi keanggotaan, menentukan fungsi implikasi dan komposisi aturan dimana pada metode mamdani, fungsi implikasi yang digunakan adalah min dalam persamaan operator fuzzy and sedangkan komposisi aturan yang digunakan pada metode mamdani yaitu aplikasi max dari operator fuzzy or, melakukan penegasan( defuzzyfikasi). Ada 2 variabel input yang digunakan yaitu harga dan kepuasan pelanggan, dan ada 1 output yang digunakan yaitu kepuasaan pelanggan. Logika fuzzy merupakan sistem untuk memecahkan masalah, dengan menerapkan logika fuzzy  dalam mendukung keputusan yang akan diambil diharapkan menghasilkan suatu keputusan sesuai dengan yang diharapkan. Dengan mengetahui tingkat kepuasan pelanggan tersebut tentunya Warkop Kopi Kita dapat mengetahui tingkat kepuasan yang didapatkan dari pelanggan yang berkunjung ke Warkop Kopi Kita.
SIFAT-SIFAT MATRIKS KETETANGGAAN PADA GRAF RODA
Authors: Nasrul  , Arman  , Jufra  , Somayasa Wayan , Budiman Herdi
Published: February 2024

Graf roda merupakan graf yang diperoleh dengan cara menambahkan satu titik pada graf lingkaran  Tujuan dari penelitian ini adalah untuk mengetahui cara menentukan sifat-sifat matriks ketetanggaan pada graf roda, juga untuk mengetahui sifat-sifat matriks ketetanggaan pada graf roda. Selanjutnya untuk menentukan sifat-sifat matriks ketetanggaan pada graf roda dimulai dari mendeskripsikan matriks ketetanggaan dari graf roda , mencari dan mengamati nilai determinan, invers, nilai eigen dan vektor eigen. Determinan matriks ketetanggaan pada graf roda    yaitu: untuk graf roda  dimana dan  maka ; dan  maka ; dan maka . Nilai invers matriks ketetanggaan  pada graf roda  yaitu untuk graf roda  dimana  tidak memiliki invers, untuk graf roda  dimana dan  dan  memiliki invers. Entri-entri diagonal utama matriks yang didiagonalisasi sama dengan nilai eigennya dan jumlah entri diagonal utamanya atau trace adalah nol.
The Akkadian Vocabulary of Noah’s Ark and its Allegorical and Ritual Significance
Authors: Maranz Nezer
Published: February 2024

The Genesis account of Noah’s Ark has long engendered a debate over the relationship between the Hebrew story and the older cuneiform flood myths. In English, this famed craft is called “the ark”. However, the phrase used in the Hebrew text is “התבה” (htbh, Masoretic ha-tebah), for which no Hebrew etymology exists. Here I present evidence that “תבה” transcribes Akkadian “Tabû”, represented by the logograms “ZI” and “I.ZI.A”—which have the constituent Sumerian meanings of “Life”, “To Lead out Life (from) Water” and “To Overcome Annihilation”. , It is part of a cuneiform semantic field that identifies the Great Flood as a repurposed metaphor for the destruction of Israel. The language details signal that the Hebraic version was originally conceptualized in cuneiform during the 6th century BC as part of a ritual invoking the rescue of the nation from exile in Babylon.
House dust mite sublingual allergen immunotherapy tablet is safe and well-tolerated in Dutch clinical practice
Authors: Tempels-Pavlica Žana , Aarts Mark C. J. , Welsing Paco M. J. , van der Meer Akke-Nynke , van der Zwan Leonard P. , Uss Elena , Knulst André C.
Published: February 2024

Background

Half (49%) of clinically diagnosed allergic rhinitis (AR) patients are sensitized to house dust mite (HDM). If allergen avoidance and symptomatic medication fail, allergen immunotherapy may be indicated.

Objective

We investigated safety and tolerability of HDM-sublingual immunotherapy by HDM-SLIT tablets in Dutch daily clinical practice.

Methods

Daily intake of 12 SQ-HDM SLIT-tablet was investigated in a prospective, multicenter, observational study (EUPAS43753). It comprised 4 consultations in 1 year. Data on safety, tolerability, treatment satisfaction, symptomatic medication, compliance, and clinical effectiveness (Control of Allergic Rhinitis and Asthma Test; CARAT) were collected. Descriptive and longitudinal regression data analysis were performed.

Results

Adult patients (n = 415), mean (SD) age 36.6 (12.2) years, 61.4% female and 36% asthmatic were included. The preponderance (65.1%) experienced adverse events (AEs). These, mostly mild (67%), AEs comprised: oral allergic reactions (58.6%), respiratory (12.4%) and gastrointestinal symptoms (9.4%). Sixty (14.5%) patients stopped due to AEs and 76 (18.3%) for non-AE reasons. CARAT scores improved clinically significant by 6 points and symptomatic medication use decreased from 96.1% to 77.4%. Most patients (74.5%) tolerated the treatment and were compliant (>86.5%). The majority of patients (62.4%) and investigators (69.4%) were satisfied with treatment.

Conclusions

HDM SLIT-tablet is a safe and well-tolerated AR treatment. AEs occur often but are mostly mild and decreasing during the first year. CARAT scores improved and symptomatic medication use decreased suggesting better control of AR with treatment. Compliance, tolerability, and treatment satisfaction are good. However, patient follow-up and compliance remain important points of attention when initiating treatment.
Developing a data-driven filament shape prediction model for 3D concrete printing
Authors: Alhussain Ali , Duarte José P. , Brown Nathan C.
Published: February 2024

With the growing global need for housing and infrastructure, 3D concrete printing (3DCP) has emerged as an innovative construction method offering several potential benefits including design flexibility, speed, and sustainability. However, enhancing the reliability of 3DCP involves managing a variety of parameters that influence various aspects of the 3D printed structure. Process parameters like nozzle velocity, nozzle diameter, nozzle height, and material flow velocity have a major impact on the structural stability and filament shape. This project aimed to develop fast and accurate data-driven models for predicting and classifying filament shape based on process parameters. A print experiment systematically varied process parameters across 144 samples. The resulting filament geometry (width, height, contact width) was measured and classified by quality. Models were trained on this data to predict filament width, contact width, filament height, and classify filaments. These models can be utilized with any buildable material - a material with a high enough yield stress to bear the weight of upper layers without significant deformation. This condition does not restrict this study’s scope as it is a prerequisite for all 3DCP applications. The models’ robustness and generalizability were confirmed through validation on literature data across various printable materials and setups. These data-driven models can aid in optimizing parameters, generating variable width filaments, and printing non-planar layers. By linking print inputs to filament outputs, this comprehensive modeling approach advances 3DCP research for more reliable and versatile concrete printing.
Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex
Authors: Cornejo Francisca , Franchini Nayhara , Cortés Bastián I. , Elgueta Daniela , Cancino Gonzalo I.
Published: February 2024

Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in these pathologies, little evidence is known about glial development. Genetic association studies have identified several genes associated with neurodevelopmental disorders. Indeed, variations in the PTPRD gene have been associated with numerous brain disorders, including autism spectrum disorder, restless leg syndrome, and schizophrenia. We previously demonstrated that constitutive loss of PTPRD expression induces significant alterations in cortical neurogenesis, promoting an increase in intermediate progenitors and neurons in mice. However, its role in gliogenesis has not been evaluated. To assess this, we developed a conditional knockout mouse model lacking PTPRD expression in telencephalon cells. Here, we found that the lack of PTPRD in the mouse cortex reduces glial precursors, astrocytes, and oligodendrocytes. According to our results, this decrease in gliogenesis resulted from a reduced number of radial glia cells at gliogenesis onset and a lower gliogenic potential in cortical neural precursors due to less activation of the JAK/STAT pathway and reduced expression of gliogenic genes. Our study shows PTPRD as a regulator of the glial/neuronal balance during cortical neurodevelopment and highlights the importance of studying glial development to understand the etiology of neurodevelopmental diseases.
Navigating P2Y12 inhibition in the labyrinth of cardio-oncology care: cangrelor bridging in patients with cancer
Authors: Ali Abdelrahman , Jewani Poonam , Bourdillon Max , Koutroumpakis Efstratios , Khalaf Shaden , Charitakis Konstantinos , Thompson Kara , Marmagkiolis Konstantinos , Deswal Anita , Iliescu Cezar
Published: February 2024

Cangrelor, a potent intravenous P2Y12 platelet inhibitor, has demonstrated effectiveness in reducing ischemic events without a corresponding increase in severe bleeding during percutaneous coronary intervention, as evidenced by the CHAMPION-PHOENIX trial. Its off-label role as a bridging antiplatelet agent for patients facing high thrombotic risks who must temporarily stop oral P2Y12 inhibitor therapy further underscores its clinical utility. This is the first case series to shed light on the application of cangrelor in cancer patients needing to pause dual antiplatelet therapy for a range of medical interventions, marking it as a pioneering effort in this domain. The inclusion of patients with a variety of cancer types and cardiovascular conditions in this series underlines the adaptability and critical role of cangrelor in managing the dual challenges of bleeding risk and the need for uninterrupted antiplatelet protection. By offering a bridge for high-risk cancer patients who have recently undergone percutaneous coronary intervention and need to halt oral P2Y12 inhibitors temporarily, cangrelor presents a practical solution. Early findings indicate it can be discontinued safely 2-4 h before medical procedures, allowing for the effective reintroduction of oral P2Y12 inhibitors without adverse effects. This evidence calls for expanded research to validate and extend these preliminary observations, emphasizing the importance of further investigation into cangrelor's applications in complex patient care scenarios.
Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation
Authors: Zhou Fang , Mao Jianhong , Jin Zhenzhen , Zhu Li , Li Xiaofang
Published: February 2024

Objective

Precocious puberty (PP) is a prevalent endocrine disorder affecting the physical and mental wellbeing of children. Identifying the triggering factors of PP has become a central issue. This study seeks to investigate the metabolomic and transcriptomic alterations in PP.

Material and methods

First, 37 school-aged girls diagnosed with PP and 25 age-matched prepubertal control girls were recruited, and the fecal samples were collected for non-targeted metabolomic analysis to screen for differentially expressed metabolites (DEMs). Subsequently, an animal model of PP was constructed by danazol administration to neonatal female rats, and both fecal non-targeted metabolomics and serum next-generation transcriptomic sequencing were performed to screen DEMs and differentially expressed genes (DEGs) in PP. Moreover, the DEM co-existing in clinical and animal models was administrated to PP rats to explore the role of the target metabolite in PP.

Results

A total of 24 DEMs in PP clinical samples and 180 DEMs and 425 DEGs in PP animal samples were identified. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these DEMs and DEGs were enriched in disease-associated pathways, including fatty acid synthesis, glycerolipid metabolism, pyrimidine metabolism, steroid hormone biosynthesis, progesterone-mediated oocyte maturation, and gonadotropin-releasing hormone (GnRH) signaling pathway, forming a tight DEM–DEG pathway regulatory network. Further DEM validation demonstrated that thymine supplementation delayed the opening of the vagina and development of PP in model rats.

Conclusion

This study reveals that the metabolomic and transcriptomic changes, along with enriched pathways, are implicated in PP based on clinical and animal analyses. The findings may provide new strategies and research avenues for PP treatment.
Research progress of periostin and osteoporosis
Authors: Yuan Chuyue , Li Junyan
Published: February 2024

Periostin, as a unique extracellular matrix, is mainly produced during ontogeny and in adult connective tissues that bear mechanical loads, such as heart valves, skin, periodontal ligaments, tendons, and bones. By binding to the integrin on the cell surface and activating Wnt/β-catenin, NF-κB, Fak and other signaling pathways, it regulates the tissues in vivo positively or negatively, and also has different effects on the occurrence and development of various diseases. Periostin is an important factor, which can promote cell proliferation, stimulate tissue repair and maintain the integrity of the structure and function of connective tissue. It also promotes the formation, regeneration and repairation of bone. Recent studies have shown that periostin is important in bone metabolic diseases. The increased expression of periostin can affect bone mineral density at different sites, and its relationship with traditional biochemical markers of bone turnover has not been conclusively established. This article reviews the research results and potential applications of periostin in osteoporosis.
The impact of health volunteering of radiology students on improving their self-skills and practical capabilities in the Kingdom of Saudi Arabia
Authors: Alzain Amel F. , Elhussein Nagwan , Hamd Zuhal Y. , Fadulelmulla Ibtisam Abdallah , Omer Awatif M. , Alotaibi Ahoud , Alsuhaymi Amani , Aljohany Maram , Alharbi Najwa , Ahmed Amna Mohamed , Hussien Rehab , Elamin Badria Awad , Mohamed Ahmed Medani Afaf , Khandaker Mayeen Uddin
Published: February 2024

Background

Volunteering is a beneficial activity with a wide range of positive outcomes, from the individual to the communal level. In many ways, volunteering has a positive impact on the development of a volunteer’s personality and experience. This study aimed to evaluate the impact of health volunteering on improving the self-skills and practical capacities of students in the western region of the Kingdom of Saudi Arabia.

Materials and methods

The study was a descriptive cross-sectional electronic web-based survey that was submitted on a web-based questionnaire; 183 students answered the survey, and then, the data were analyzed using SPSS.

Results

This study shows that 95.6% of participants agree and strongly agree that the health volunteering experience was useful, 2.7% of the participants neither agree nor disagree, and 1.6% disagree and strongly disagree. Regarding the distribution of the participants on skills learned from volunteering experience, the largest proportion of student (36.1%) volunteers in the health sector acquired communication skills and the smallest proportion of student (14.8%) volunteers in the acquired time management skills. Regarding the disadvantages, 81.4% of the participants do not think there were any disadvantages to their previous health volunteering experience, while only 18.6% of them think there were any disadvantages to their previous health volunteering experience. Additionally, the study found that the type of the sector affects the skills acquired from health volunteering.

Conclusion

Research revealed that the majority considered volunteering a great experience. Volunteering increased the self-skills and practical capacities of radiology students, which proved the hypothesis.
Models of gouty nephropathy: exploring disease mechanisms and identifying potential therapeutic targets
Authors: Wang Lin , Zhang Xiaoyu , Shen Jiayan , Wei Yuanyuan , Zhao Ting , Xiao Niqin , Lv Xiaoman , Qin Dongdong , Xu Yundong , Zhou Yang , Xie Jing , Li Zhaofu , Xie Zhaohu
Published: February 2024

Gouty nephropathy (GN) is a metabolic disease with persistently elevated blood uric acid levels. The main manifestations of GN are crystalline kidney stones, chronic interstitial nephritis, and renal fibrosis. Understanding the mechanism of the occurrence and development of GN is crucial to the development of new drugs for prevention and treatment of GN. Currently, most studies exploring the pathogenesis of GN are primarily based on animal and cell models. Numerous studies have shown that inflammation, oxidative stress, and programmed cell death mediated by uric acid and sodium urate are involved in the pathogenesis of GN. In this article, we first review the mechanisms underlying the abnormal intrinsic immune activation and programmed cell death in GN and then describe the characteristics and methods used to develop animal and cell models of GN caused by elevated uric acid and deposited sodium urate crystals. Finally, we propose potential animal models for GN caused by abnormally high uric acid levels, thereby provide a reference for further investigating the methods and mechanisms of GN and developing better prevention and treatment strategies.