bluuebunny/crossref_metadata_2025 huggingface dataset:
Cementitious Composites with Cellulose Nanomaterials and Basalt Fiber Pellets: Experimental and Statistical Modeling
Authors: Hosny O. M. , Yasien A. M. , Bassuoni M. T. , Gourlay K. , Ghazy A.
Published: January 2024

The production of high-performance fiber-reinforced cementitious composites (HPFRCCs) as a durable construction material using different types of fibers and nanomaterials critically relies on the synergic effects of the two materials as well as the cementitious composite mixes. In this study, novel HPFRCCs were developed, which comprised high content (50%) slag by mass of the base binder as well as nano-silica (NS) or nano-crystalline cellulose (NCC). In addition, nano-fibrillated cellulose (NFC), and basalt fiber pellets (BFP), representing nano-/micro- and macro-fibers, respectively, were incorporated into the composites. The response surface method was used in this study’s statistical modeling part to evaluate the impact of key factors (NS, NCC, NFC, BFP) on the performance of 15 mixtures. The composites were assessed in terms of setting times, early- and late-age compressive strength, flexural performance, and resistance to freezing-thawing cycles, and the bulk trends were corroborated by fluid absorption, thermogravimetry, and microscopy tests. Incorporating NS/NCC in the slag-based binders catalyzed the reactivity of cement and slag with time, thus maintaining the setting times within an acceptable range (maximum 9 h), achieving high early- (above 33 MPa at 3 days) and later-age (above 70 MPa at 28 days) strength, and resistance to fluid absorption (less than 2.5%) and frost action (DF above 90%) of the composites. In addition, all nano-modified composites with multi-scale fibers showed notable improvement in terms of post-cracking flexural performance (Residual Strength Index above 40%), which qualify them for multiple infrastructure applications (i.e., shear key bridge joints) requiring a balance between high-strength properties, ductility, and durability.
The Asymptotic Structure of Canonical Wall-Bounded Turbulent Flows
Authors: Heinz Stefan
Published: January 2024

Our ability to reliably and efficiently predict complex high-Reynolds-number (Re) turbulent flows is essential for dealing with a large variety of problems of practical relevance. However, experiments as well as computational methods such as direct numerical simulation (DNS) and large eddy simulation (LES) face serious questions regarding their applicability to high Re turbulent flows. The most promising option to create reliable guidelines for experimental and computational studies is the use of analytical conclusions. An essential criterion for the reliability of such analytical conclusions is the inclusion of a physically plausible explanation of the asymptotic turbulence regime at infinite Re in consistency with observed physical requirements. Corresponding analytical results are reported here for three canonical wall-bounded turbulent flows: channel flow, pipe flow, and the zero-pressure gradient turbulent boundary layer. The asymptotic structure of the mean velocity and characteristic turbulence velocity, length, and time scales is analytically determined. In outer scaling, a stable asymptotic mean velocity distribution is found corresponding to a linear probability density function of mean velocities along the wall-normal direction, which is modified through wake effects. Turbulence tends to decay in this regime. In inner scaling, the mean velocity is governed by a universal log-law. Turbulence does survive in an infinitesimally thin layer very close to the wall.
Control of Aerodynamic Characteristics of Thick Airfoils at Low Reynolds Numbers Using Methods of Boundary Layer Control
Authors: Bulat Pavel , Chernyshov Pavel , Prodan Nikolay , Volkov Konstantin
Published: January 2024

The article explores flow behavior around thick airfoils at low Reynolds numbers and the potential application of energy methods to manipulate the flow field for increased lift and reduced drag. The study relies on a set of propulsion airfoils calculated using a combined approach of solving the inverse problem of aerodynamics and applying stochastic global optimization methods. The calculations consider the transition from laminar to turbulent flow regimes, which significantly affects lift and airfoil drag. The suitability of different turbulence models for airfoil modeling in low Reynolds numbers is discussed, and numerical simulation results determine the lift coefficient dependence on angle of attack and the optimal air flow rate taken from the airfoil surface for each angle of attack. The accuracy of different turbulence models is analyzed by comparing numerical simulation results to physical experiment data.
Combined Effects of Clarifying Agents Improve Physicochemical, Microbial and Sensorial Qualities of Fresh Indian Gooseberry (Phyllanthus emblica L.) Juice during Refrigerated Storage
Authors: Jafari Saeid , Shiekh Khursheed Ahmad , Mishra Dharmendra K. , Kijpatanasilp Isaya , Assatarakul Kitipong
Published: January 2024

Using clarifying agents is essential in the production of fruit juice. This study utilized gelatin and bentonite as clarifying agents to improve the quality and shelf-life of Indian gooseberry juice (IGBJ). Different treatments were prepared using varying levels of gelatin and bentonite alone or in combination (1.5–2 mg/mL and 1–2 mg/mL, respectively). The untreated IGBJ was used as a control. The results showed the combined treatment of 1.5 mg/mL gelatin and 1 mg/mL bentonite significantly (p ≤ 0.05) improved the transmittance, △E value, total acidity, vitamin C, and antioxidant activity of the IGBJ sample. During storage for 49 days at 4 °C, the quality changes in the IGBJ were minimal with the use of 1.5 mg/mL gelatin and 1 mg/mL bentonite compared to the control (p > 0.05). The treated samples showed no signs of spoilage bacteria, yeast, or mold during cold storage. The combined use of gelatin and bentonite (1.5 mg/mL gelatin and 1 mg/mL bentonite) was found to effectively preserve the sensory quality, bioactivity, and color properties of IGBJ, thereby extending its shelf-life. Thus, gelatin and bentonite can be used as preferred filtering aids for quality and shelf-life extension in the food industry, as they have synergistic effects.
Comprehensive Effects of Potassium Lactate, Calcium Ascorbate and Magnesium Chloride as Alternative Salts on Physicochemical Properties, Sensory Characteristics and Volatile Compounds in Low-Sodium Marinated Beef
Authors: Yang Shujie , Ma Xiaoli , Huang Yanfeng , Lin Boyue , Zhang Longtao , Miao Song , Zheng Baodong , Deng Kaibo
Published: January 2024

The search for alternative salt formulations similar to sodium chloride and their effect on marinated meat products is of great significance to the low-sodium meat processing industry. The main purpose of this study was to investigate the effect of partially replacing sodium chloride with potassium lactate, calcium ascorbate, and magnesium chloride on the sodium content, water activity and distribution, protein solubility, microstructure, sensory characteristics and volatile flavor compounds in low-sodium marinated beef. The sodium content in the test group decreased up to 28% compared to 100% in the sodium chloride group C1. The formulation including 60% sodium chloride and a total of 40% compound alternative salts in groups F1 and F2 increased their myofibril fragmentation index and promoted the disruption of the myogenic fiber structure. Group F1 (the ratio of potassium lactate, calcium ascorbate and magnesium chloride was 2:1:1) performed higher solubility of myofibrillar proteins and lower transverse relaxation value than group F2 detected by low-field nuclear magnetic resonance, which indicated that F1 formulation was beneficial to promote the solubility of myofibrillar proteins and attenuate the water mobility of marinated beef. Moreover, group F1 had a more similar microstructure and more similar overall sensory attributes to group C1 according to the scanning electron microscopy. The sensory evaluation showed higher peak intensity and response values of volatile flavor compounds than group C1 and C2 (only 60% sodium chloride) when detected using gas chromatography–ion mobility spectrometry technology, which indicated that the compound alternative salts of group F1 can improve the lower quality of low-sodium marinated beef and perform similar attributes to the C1 sample regarding moisture distribution and microstructure and even performs better than it with regards to flavor. Therefore, the F1 formula possessed greater potential for application in low-sodium marinated meat products.
Exploring the Blood Glucose-Lowering Potential of the Umami Peptides LADW and EEAEGT Derived from Tuna Skeletal Myosin: Perspectives from α-Glucosidase Inhibition and Starch Interaction
Authors: Zhao Shuai , Cai Shengbao , Ding Lixin , Yi Junjie , Zhou Linyan , Liu Zhijia , Chu Chuanqi
Published: January 2024

This study aimed to explore the potential of umami peptides for lowering blood glucose. Molecular docking results showed that the peptides LADW and EEAEGT bound to the active amino acid residues of α-glucosidase via hydrogen bonds and Van der Waals forces, a finding supported by an independent gradient model (IGM). Molecular dynamics (MD) simulations demonstrated that the peptides LADW and EEAEGT can decelerate the outward expansion of α-glucosidase and reduce amino acid fluctuations at the active site. In vitro findings indicated that the peptides LADW and EEAEGT showed potent inhibitory activity against α-glucosidase, with IC50 values of 4.40 ± 0.04 and 6.46 ± 0.22 mM, respectively. Furthermore, MD simulation and morphological observation results also revealed that LADW and EEAEGT alter starch structure and form weak interactions with starch through intermolecular hydrogen bonding, leading to the inhibition of starch hydrolysis. Peptides inhibit the ability of starch to produce reducing sugars after simulated gastrointestinal digestion, providing additional evidence of the inhibition of starch hydrolysis by the added peptides. Taken together, these findings suggest that consuming the umami peptides LADW and EEAEGT may alleviate postprandial blood glucose elevations via inhibiting α-glucosidase and starch hydrolysis.
Growth Control of Listeria monocytogenes in Raw Sausage via Bacteriocin-Producing Leuconostoc carnosum DH25
Authors: Tönz Andrea , Freimüller Leischtfeld Susette , Stevens Marc J. A. , Glinski-Häfeli Deborah , Ladner Valentin , Gantenbein-Demarchi Corinne , Miescher Schwenninger Susanne
Published: January 2024

The current study addresses the critical issue of Listeria monocytogenes growth in raw sausage/meat products leading to human infections, most commonly listeriosis, which is known for its high fatality rate. This research focuses on the isolation, identification, and screening of lactic acid bacteria from various meat and fish products in Switzerland. In total, 274 lactic acid bacteria strains were isolated from 30 different products and were screened for their ability to inhibit Listeria monocytogenes growth, with 51 isolates demonstrating anti-Listeria activity at 8 °C, 15 °C, 25 °C, and 37 °C. Further experiments, using a meat model and a raw sausage challenge test, demonstrated that Leuconostoc carnosum DH25 significantly inhibited Listeria monocytogenes growth during the ripening and storage of the tested meat/sausage. This inhibitory effect was found to be attributed to the bacteriocins produced by Leuconostoc carnosum DH25 rather than factors like pH or water activity. The stability of the anti-Listeria substances was examined, revealing their resistance to temperature and pH changes, making Leuconostoc carnosum DH25 a promising protective culture for raw sausages. The genome sequencing of this strain confirms its safety, with no antibiotic resistance genes or virulence factors detected, and reveals the presence of the structural genes for the production of the bacteriocin LeucocinB-Ta11a. This study underscores the potential of LAB strains and their bacteriocins as effective tools for enhancing food safety and preventing Listeria monocytogenes growth in meat products, offering valuable insights into biocontrol strategies in the food industry.
Variability within L. albus and L. angustifolius Seeds in Dietary Fiber Components
Authors: González Elena , Carrapiso Ana Isabel , Canibe Nuria , Bach Knudsen Knud Erik
Published: January 2024

Lupin seeds have received increased attention due to their applications in the nutrition of humans and livestock. One of their special features is their high content of dietary fiber, which is influenced by the lupin species. No previous studies have focused on the variability in dietary fiber and its fractions within species so far. The aim of this study was to investigate the variability within L. albus and L. angustifolius (eight cultivars each) in the dietary fiber composition expressed as low-molecular-weight soluble dietary fiber (LMWSDF), soluble and insoluble non-cellulosic polysaccharides, cellulose, and Klason lignin. Additionally, we analyzed the proximate composition and the composition of amino acids and fatty acids. The results showed noticeable variability within both species not only in the total dietary fiber but also in all its fractions, especially in LMWSDF, cellulose, non-starch polysaccharides, and Klason lignin within L. angustifolius. This indicates that the cultivar choice should be based on the application for which it is used. Even though important nutrients, such as the most indispensable amino acids, are not highly variable within L. albus, dietary fiber variations can still have a marked influence on the nutritional value because of their influence on the digestibility of other nutrients.
Solutions for Hilfer-Type Linear Fractional Integro-Differential Equations with a Variable Coefficient
Authors: Zhu Sigang , Wang Huiwen , Li Fang
Published: January 2024

In this paper, we derive an explicit formula of solutions to Hilfer linear fractional integro-differential equations with a variable coefficient in a weighted space, and obtain the existence and uniqueness of solutions for fractional kinetic equations and fractional integro-differential equations with a generalized Mittag–Leffler function. An example is given to illustrate the result obtained.
Local Singularity Spectrum: An Innovative Graphical Approach for Analyzing Detrital Zircon Geochronology Data in Provenance Analysis
Authors: Wang Wenlei , Pei Yingru , Cheng Qiuming , Wang Wenjun
Published: January 2024

Detrital zircon geochronology plays a crucial role in provenance analysis, serving as one of the fundamental strategies. The age spectrum of detrital zircons collected from the sedimentary unit of interest is often compared or correlated with that of potential source terranes. However, biases in the age data can arise due to factors related to detrital sampling, analysis techniques, and nonlinear geological mechanisms. The current study reviewed two sets of detrital zircon datasets established in 2011 and 2021 to discuss the origins of the Tibetan Plateau. These datasets collected from different media effectively demonstrate a progressive understanding of provenance affinity among the main terranes on the Tibetan Plateau. This highlights issues regarding weak and unclear temporal connections identified through analyzing the age spectrum for provenance analysis. Within this context, a local singularity analysis approach is currently employed to address issues associated with unclear and weak provenance information by characterizing local variations in nonlinear behaviors and enhancing detection sensitivity towards subtle anomalies. This new graphical approach effectively quantifies temporal variations in detrital zircon age populations and enhances identification of weak provenance information that may not be readily apparent on conventional age spectra.
A Novel Numerical Method for Solving Nonlinear Fractional-Order Differential Equations and Its Applications
Authors: Lee Seyeon , Kim Hyunju , Jang Bongsoo
Published: January 2024

In this article, a considerably efficient predictor-corrector method (PCM) for solving Atangana–Baleanu Caputo (ABC) fractional differential equations (FDEs) is introduced. First, we propose a conventional PCM whose computational speed scales with quadratic time complexity O(N2) as the number of time steps N grows. A fast algorithm to reduce the computational complexity of the memory term is investigated utilizing a sum-of-exponentials (SOEs) approximation. The conventional PCM is equipped with a fast algorithm, and it only requires linear time complexity O(N). Truncation and global error analyses are provided, achieving a uniform accuracy order O(h2) regardless of the fractional order for both the conventional and fast PCMs. We demonstrate numerical examples for nonlinear initial value problems and linear and nonlinear reaction-diffusion fractional-order partial differential equations (FPDEs) to numerically verify the efficiency and error estimates. Finally, the fast PCM is applied to the fractional-order Rössler dynamical system, and the numerical results prove that the computational cost consumed to obtain the bifurcation diagram is significantly reduced using the proposed fast algorithm.
Association of Genetic Markers with the Risk of Early-Onset Breast Cancer in Kazakh Women
Authors: Skvortsova Liliya , Abdikerim Saltanat , Yergali Kanagat , Mit Natalya , Perfilyeva Anastassiya , Omarbayeva Nazgul , Zhunussova Aigul , Kachiyeva Zulfiya , Sadykova Tolkyn , Bekmanov Bakhytzhan , Kaidarova Dilyara , Djansugurova Leyla , Zhunussova Gulnur
Published: January 2024

Breast cancer is a global health problem. It is an age-dependent disease, but cases of early-onset breast cancer (eBC) are gradually increasing. There are many unresolved questions regarding eBC risk factors, mechanisms of development and screening. Only 10% of eBC cases are due to mutations in the BRCA1/BRCA2 genes, and 90% have a more complex genetic background. This poses a significant challenge to timely cancer detection in young women and highlights the need for research and awareness. Therefore, identifying genetic risk factors for eBC is essential to solving these problems. This study represents an association analysis of 144 eBC cases and 163 control participants to identify genetic markers associated with eBC risks in Kazakh women. We performed a two-stage approach in association analysis to assess genetic predisposition to eBC. First-stage genome-wide association analysis revealed two risk intronic loci in the CHI3L2 gene (p = 5.2 × 10−6) and MGAT5 gene (p = 8.4 × 10−6). Second-stage exonic polymorphisms haplotype analysis showed significant risks for seven haplotypes (p < 9.4 × 10−4). These results point to the importance of studying medium- and low-penetrant genetic markers in their haplotype combinations for a detailed understanding of the role of detected genetic markers in eBC development and prediction.
Genome-Wide Identification and Expression Analysis of the MYB Transcription Factor Family in Salvia nemorosa
Authors: Yang Huan , Chen Chen , Han Limin , Zhang Xiao , Yue Ming
Published: January 2024

The MYB transcription factor gene family is among the most extensive superfamilies of transcription factors in plants and is involved in various essential functions, such as plant growth, defense, and pigment formation. Salvia nemorosa is a perennial herb belonging to the Lamiaceae family, and S. nemorosa has various colors and high ornamental value. However, there is little known about its genome-wide MYB gene family and response to flower color formation. In this study, 142 SnMYB genes (MYB genes of S. nemorosa) were totally identified, and phylogenetic relationships, conserved motifs, gene structures, and expression profiles during flower development stages were analyzed. A phylogenetic analysis indicated that MYB proteins in S. nemorosa could be categorized into 24 subgroups, as supported by the conserved motif compositions and gene structures. Furthermore, according to their similarity with AtMYB genes associated with the control of anthocyanin production, ten SnMYB genes related to anthocyanin biosynthesis were speculated and chosen for further qRT-PCR analyses. The results indicated that five SnMYB genes (SnMYB75, SnMYB90, SnMYB6, SnMYB82, and SnMYB12) were expressed significantly differently in flower development stages. In conclusion, our study establishes the groundwork for understanding the anthocyanin biosynthesis of the SnMYB gene family and has the potential to enhance the breeding of S. nemorosa.
Experimental Study of Energy Design Optimization for Underwater Electrical Shockwave for Fracturing Applications
Authors: Awad Mohamed M. , Eltaleb Ibrahim , Soliman Mohamed Y.
Published: January 2024

Underwater electrical shockwave can be used as a waterless, chemical-free, and environmentally friendly fracturing technique. A detailed experimental study was performed to develop a correlation between the optimum energy required to generate a shockwave that could be used in fracturing rock samples with the wire weight and diameter as independent factors. In addition, the effect of the water volume on the Underwater Electrical Wire Explosion (UEWE) was investigated to quantify the effect of the wellbore fluid volume in the fracturing process. The effect of increasing the discharge energy on the current waveform rising rate, peak amplitude, and fracturing geometry was investigated. A baseline for implementing the shockwave fracturing method on cement and limestone samples was defined to be used in future work. The results show that the water volume has a significant effect on the results of the experiment. A correlation was developed that defined the optimum minimum energy required to burn a certain wire weight with consideration to the wire diameter. Using the optimum required energy or higher will increases the current peak amplitude with the same current waveform rise rate, which leads to higher energy deposition into the wire and prevents the premature breakdown of the wire. The generated shockwave was used to successfully fracture cement and limestone cubic samples.
Methodology and Experimental Protocol for Studying Learning and Motor Control in Neuromuscular Structures in Pilates
Authors: Pereira Mário José , André Alexandra , Monteiro Mário , Castro Maria António , Mendes Rui , Martins Fernando , Gomes Ricardo , Vaz Vasco , Dias Gonçalo
Published: January 2024

The benefits of Pilates have been extensively researched for their impact on muscular, psychological, and cardiac health, as well as body composition, among other aspects. This study aims to investigate the influence of the Pilates method on the learning process, motor control, and neuromuscular trunk stabilization, specifically in both experienced and inexperienced practitioners. This semi-randomized controlled trial compares the level of experience among 36 Pilates practitioners in terms of motor control and learning of two Pilates-based skills: standing plank and side crisscross. Data will be collected using various assessment methods, including abdominal wall muscle ultrasound (AWMUS), shear wave elastography (SWE), gaze behavior (GA) assessment, electroencephalography (EEG), and video motion. Significant intra- and inter-individual variations are expected, due to the diverse morphological and psychomotor profiles in the sample. The adoption of both linear and non-linear analyses will provide a comprehensive evaluation of how neuromuscular structures evolve over time and space, offering both quantitative and qualitative insights. Non-linear analysis is expected to reveal higher entropy in the expert group compared to non-experts, signifying greater complexity in their motor control. In terms of stability, experts are likely to exhibit higher Lyapunov exponent values, indicating enhanced stability and coordination, along with lower Hurst exponent values. In elastography, experienced practitioners are expected to display higher transversus abdominis (TrA) muscle elasticity, due to their proficiency. Concerning GA, non-experts are expected to demonstrate more saccades, focus on more Areas of Interest (AOIs), and shorter fixation times, as experts are presumed to have more efficient gaze control. In EEG, we anticipate higher theta wave values in the non-expert group compared to the expert group. These expectations draw from similar studies in elastography and correlated research in eye tracking and EEG. They are consistent with the principles of the Pilates Method and other scientific knowledge in related techniques.
Comparative Analysis of the Impact of Training through Simulation Using the Crisis Resource Management Tool for Primary Care Professionals
Authors: Bernardino-Santos Marta , Arnal-Velasco Daniel , Reboto-Cortés Pilar , Garmendia-Fernandez Cristina , Renilla-Sánchez Esther , Navalón-Liceras Ricardo Jose , Botillo-Pérez Elena , Ortega Miguel A. , Gómez-Arnau Díaz-Cañabate Juan Ignacio , De León-Luis Juan A.
Published: January 2024

This was a prospective observational study based on clinical simulation courses taught in 2017 at the IDEhA Simulation Center of Alcorcón Foundation University Hospital. Two courses in metabolic emergencies (MEs) and respiratory emergencies (REs) were offered to primary care physicians all over Spain. The main objective was to teach nontechnical skills (crisis resource management). Using a modified five-level Kirkpatrick–Phillips education evaluation model, level I (reaction, K1), level II (learning, K2) and level III (behavioral change, K3) changes were evaluated through surveys at the end of the courses and one year later. Thirty courses were held (15 ME courses and 15 RE courses) with 283 primary care physicians. The overall satisfaction (K1) was high: ME courses, 9.5/10; RE courses, 9.6/10. More than 80% of the participants rated the organization, resources, content, debriefing and scenarios as excellent, with no significant differences between the two courses. After one year (156 responses), the respondents for both courses reported that they would repeat the training annually (K2), encourage debriefing with colleagues (K3) and have modified some aspects of their workplace (K3), citing improvements in procedures and in the organization of the health team as the most important. After the ME course, few participants, i.e., 5 (6%), reported providing improved care to patients; after the RE course, 15 (19%) participants reported providing improved care; the difference between groups was significant (p < 0.05). Compared with the ME course, the RE course imparted greater knowledge about patient safety (K2) (38 (49%) vs. 24 (31%) (p < 0.05)) and more useful tools for daily clinical practice (K3) (67% vs. 56.4%) and resulted in participants paying more attention to personal performance and to colleagues when working as a team (K2) (64% vs. 50%). Clinical simulation courses are highly valued and potentially effective for training primary care physicians in patient safety and CRM tools. Future studies with objective measures of long-term impact, behavior in the workplace (K3) and benefits to patients (K4) are needed. Based on the results of our study, the areas that are important are those aimed at improving procedures and the organization of health teams.
Identification of Barriers for Active Disease Management and of Medication-Related Problems through Therapeutic Patient Education in Older Home-Care Patients
Authors: Grigolo Sabrina , Bruschi Barbara , Di Masi Diego , Bena Carla , Armando Lucrezia Greta , Cena Clara
Published: January 2024

Combining therapeutic patient education (TPE) with a medication review service could foster the adoption of appropriate lifestyles by patients and support care-providers in identifying strategies to improve the quality of prescribed care. This study aimed to identify barriers experienced by patients in managing their diseases and medication-related problems. This was a monocentric, case series, observational study involving home-care patients from the Local Health Authority ASL TO4. Patients were enrolled for a TPE intervention where drug therapies and patient habits were collected through narrative interviews. Medication review was performed to identify potentially inappropriate prescriptions (PIPs). Twenty patients (13 females) with a mean age of 74.7 years were enrolled. Patients had an average of 4.3 diseases and 80.0% of them were treated with ≥5 daily medications. The main PIPs involved ibuprofen, furosemide and pantoprazole. The qualitative analysis of the interviews identified seven macro-themes relating to different aspects of medication management: therapy; diseases; patient; patient journey; professionals; family and caregivers; drug information. The results of this study revealed some critical aspects related to the treatment path and healthcare professionals. These results will be used to plan educational interventions for polypharmacy patients to improve medication adherence and the understanding and management of diseases.
Quality of Life in Systemic Lupus Erythematosus and Other Chronic Diseases: Highlighting the Amplified Impact of Depressive Episodes
Authors: Primavera Diego , Carta Mauro Giovanni , Romano Ferdinando , Sancassiani Federica , Chessa Elisabetta , Floris Alberto , Cossu Giulia , Nardi Antonio Egidio , Piga Matteo , Cauli Alberto
Published: January 2024

Background: Extensive research has explored SLE’s impact on health-related quality of life (H-QoL), especially its connection with mental wellbeing. Recent evidence indicates that depressive syndromes significantly affect H-QoL in SLE. This study aims to quantify SLE’s impact on H-QoL, accounting for comorbid depressive episodes through case-control studies. Methods: A case-control study was conducted with SLE patients (meeting the ACR/EULAR 2019 criteria of age ≥ 18). The control group was chosen from a community database. H-QoL was measured with the SF-12 questionnaire, and PHQ-9 was used to assess depressive episodes. Results: SLE significantly worsened H-QoL with an attributable burden of 5.37 ± 4.46. When compared to other chronic diseases, only multiple sclerosis had a worse impact on H-QoL. Major depressive episodes had a significant impact on SLE patients’ H-QoL, with an attributable burden of 9.43 ± 5.10, similar to its impact on solid cancers but greater than its impact on other diseases. Conclusions: SLE has a comparable impact on QoL to serious chronic disorders. Concomitant depressive episodes notably worsened SLE patients’ QoL, exceeding other conditions, similar to solid tumors. This underscores the significance of addressing mood disorders in SLE patients. Given the influence of mood disorders on SLE outcomes, early identification and treatment are crucial.
Relationship between Solitary Masturbation and Sexual Satisfaction: A Systematic Review
Authors: Cervilla Oscar , Álvarez-Muelas Ana , Sierra Juan Carlos
Published: January 2024

Masturbation is a healthy sexual behavior associated with different sexual functioning dimensions, which highlights sexual satisfaction as an important manifestation of sexual wellbeing. This review aims to systematically examine studies that have associated masturbation with sexual satisfaction, both in individuals with and without a partner. Following the PRISMA statement, searches were made in the APA PsycInfo, Medline, Scopus, and Web of Science databases. The search yielded 851 records, and twenty-two articles that examined the relation between solitary masturbation and sexual satisfaction were selected. In men, a negative relation between masturbation and sexual satisfaction was observed in 71.4% of the studies, 21.4% found no such relation, and 7.2% observed a positive association. In women, 40% reported no relation, 33.3% a negative relation, and 26.7% a positive one. The negative association between solitary masturbation and sexual satisfaction is consistent with the previously proposed compensatory role of masturbation, especially for men. In women, compared to men, the complementary role of masturbation in relation to sexual relationships is observed to a greater extent and is associated more closely with sexual health. The importance of including different parameters beyond the masturbation frequency in future studies to explore its relation with sexual satisfaction is emphasized. This systematic review is registered in PROSPERO (CRD42023416688).
Effects of Exogenous Melatonin on the Growth and Physiological Characteristics of Ginkgo biloba L. under Salinity Stress Conditions
Authors: Zhou Dan , Li Meng , Wang Xiujun , Li Haiyan , Li Zihang , Li Qingwei
Published: January 2024

Ginkgo (Ginkgo biloba L.) is a cherished relic among plants, commonly planted as a street tree. However, it faces cultivation challenges due to escalating soil salinization and widespread snowmelt application. Therefore, this study used 4-year-old Ginkgo seedlings to investigate how exogenous melatonin at varying concentrations affects seedling growth and physiology under salinity stress. The results revealed that appropriate melatonin concentrations (0.02, 0.1 mmol·L−1) significantly mitigated leaf yellowing under different NaCl stress levels. Furthermore, they increased ground diameter, current-year branch growth, relative water concentration, free proline, and soluble sugars in leaves. Melatonin also reduced electrolyte exudation rates, flavonoids, and malonic dialdehyde concentration, while enhancing peroxidase and superoxide dismutase activities. This led to reduced chlorophyll content, photosynthetic rate, stomatal conductance, and transpiration rate, stabilizing intercellular CO2 concentration, preserving photosynthetic structures, and enhancing photosynthetic rates. Additionally, the decline in the photosynthetic electron transport rate, the effective photochemical quantum yield of PSII, and the potential efficiency of primary conversion of light energy of PSII was alleviated. Minimal fluorescence and the non-photochemical quenching coefficient also improved. However, high melatonin concentration (0.5 mmol·L−1) exacerbated salinity stress. After analyzing composite scores, the 0.02 mmol·L−1 melatonin treatment was most effective in alleviating NaCl stress, while the 0.5 mmol·L−1 treatment intensified physiological stress under 200 mmol·L−1 NaCl stress. Principal component analysis and correlation analysis identified seven physiological indicators (photosynthetic rate, transpiration rate, photosynthetic electron transport rate, minimal fluorescence, superoxide dismutase, free proline, and chlorophyll a) and three growth indicators (ground diameter, branch length, and current-year branch thickness) as key markers for rapid salinity stress assessment in Ginkgo. These findings are crucial for addressing challenges associated with snowmelt’s impact on roadside Ginkgo trees, expanding planting areas, and breeding exceptional salt-tolerant Ginkgo varieties.
Resident Support for the Federally Mandated Smoke-Free Rule in Public Housing: 2018–2022
Authors: Dearfield Craig T. , Ulfers Margaret , Horn Kimberly , Bernat Debra H.
Published: January 2024

This study examines support for the Department of Housing and Urban Development’s (HUD) mandatory smoke-free rule up to four years post-rule among smokers and non-smokers. A repeated cross-sectional design was used where District of Columbia public housing residents aged 18+ (n = 529) completed surveys during three time points: July 2018 (pre-rule), November 2018–March 2020 (post-rule), and September 2020–December 2022 (post-rule + COVID-19). Full support for the rule was indicated by agreeing that smoking should not be allowed in all indoor locations and within 25 feet of buildings. Descriptive statistics showed significant differences in support across time for smokers (5.3%, 30.7%, and 22.5%, respectively) and similar support across time for nonsmokers (48.2%, 52.2%, and 40.0%, respectively). In unstratified regression analysis, pre-rule support was lower than when the rule was in effect (aOR = 0.47, 95% CI = 0.25, 0.90), and tobacco users were less likely to support the rule (aOR = 0.34, 95% CI = 0.23, 0.50). Stratified logistic regression results showed that pre-rule support was lower among smokers compared to post-rule support (aOR = 0.14, 95% CI = 0.03, 0.59); support among nonsmokers did not vary by time. Findings overall indicate low support for the smoke-free rule up to 4 years post-implementation. Engaging residents with the rule and promoting health and well-being may further enhance policy effectiveness and acceptance.
Pilot Evaluation of a Remote Psychotherapy Service for Students Who Self-Harm: University–Community Outpatient Psychotherapy Engagement (U-COPE)
Authors: Worsley Joanne , Young Danielle , Harrison Paula , Corcoran Rhiannon
Published: January 2024

Self-harm is becoming increasingly common in student populations. Brief psychological therapies might be helpful for those who have recently self-harmed. The current paper reports on an evaluation of a brief psychotherapy service delivered via remote means, namely University–Community Outpatient Psychotherapy Engagement (U-COPE). The service combines elements of psychodynamic interpersonal and cognitive analytic therapy to help students who present with self-harm related difficulties. The primary aim was to understand students’ and practitioners’ experiences of a remote psychotherapy service. Semi-structured interviews were conducted with a total of nine participants (seven students and two practitioners). Interview data were analysed using thematic analysis. Analyses of the interviews across the stakeholders revealed three overarching themes: ‘Accessibility’; ‘Therapeutic experiences’; and ‘Spaces and places of therapy’. Students appreciated the rapid access to intervention, especially as student services are typically characterised by long waiting lists. Despite the brief nature of the intervention, many students reported feeling a sense of control over the direction and pace of the therapeutic sessions, which is an important consideration for those who self-harm. The findings suggest that U-COPE may be helpful to students with difficulties related to self-harm. Further investigation of this brief intervention is warranted in order to ascertain whether U-COPE has a long-term impact on difficulties and distress-related behaviours.
Chronic Hepatitis C Cascade of Care in Prisoners—Is There Still Some Work to Do? Analysis of Two Large Penitentiaries in Northern Italy
Authors: Cambianica Anna , Marchese Valentina , Pennati Francesca , Faustinelli Alessandro , Migliorati Manuela , Roda Fabio , Spinetti Angiola , Zaltron Serena , Fiorentini Simona , Caruso Arnaldo , Quiros-Roldan Eugenia , Castelli Francesco , Focà Emanuele
Published: January 2024

Penitentiaries have a higher burden of communicable diseases compared to the general population. Prisoners should be tested for hepatitis C virus (HCV) and have direct access to treatment. We analysed the HCV cascade of care in two penitentiaries in Brescia, Northern Italy. At admission, prisoners are offered a voluntary screening for HCV, while patients with known infections are tested with an HCVRNA measurement. We performed an observational retrospective study including all the subjects admitted to the penitentiaries from 1 January 2015 to 31 October 2021. We conducted a descriptive analysis. During the study period, 5378 admissions were registered, and 2932 (54.5%) screenings were performed. Hepatitis C virus antibody positivity was found in 269 tests (9.2%). Hepatitis C virus RNA was detectable in 169 people. During the study period, 77 treatments with direct-acting antivirals (DAAs) were administered. Follow-up was available in 45 patients, and sustained virological response (SVR) was documented in 44 of them. Retention in care occurred in less than half of the prisoners after release. Our data demonstrate poor screening adherence that could benefit from educational programs. Treatment rates could be improved with test-and-treat programs. More efforts are needed to eliminate HCV as a public threat by 2030. Dedicated local networks, including infectious diseases (ID) departments, substance abuse services and prisons, could mitigate these issues.
3D Cadastral Database Systems—A Systematic Literature Review
Authors: Shahidinejad Javad , Kalantari Mohsen , Rajabifard Abbas
Published: January 2024

Cadastral databases have been used for over 20 years, but most contain 2D data. The increasing presence of high-rise buildings with modern architecture complicates the process of determining property rights, restrictions, and responsibilities. It is, therefore, necessary to develop an efficient system for storing and managing multidimensional cadastral data. While there have been attempts to develop 3D cadastral database schemas, a comprehensive solution that meets all the requirements for effective data storage, manipulation, and retrieval has not yet been presented. This study aims to analyse the literature on 3D cadastral databases to identify approaches and technologies for storing and managing these data. Based on a systematic literature review integrated with a snowballing methodology, 108 documents were identified. During the analysis of the related documents, different parameters were extracted, including the conceptual data model, query type, and evaluation metrics, as well as the database management system (DBMS) used and technologies for visualisation, data preparation, data transformation, and the ETL (extract, transform, and load) process. The study emphasised the importance of adhering to database design principles and identified challenges associated with conceptual design, DBMS selection, logical design, and physical design. The study results provide insights for selecting the appropriate standards, technologies, and DBMSs for designing a 3D cadastral database system.
Mesenchymal Stem/Stromal Cells Induce Myeloid-Derived Suppressor Cells in the Bone Marrow via the Activation of the c-Jun N-Terminal Kinase Signaling Pathway
Authors: Lee Hyun Ju , Oh Joo Youn
Published: January 2024

Our previous study demonstrated that mesenchymal stem/stromal cells (MSCs) induce the differentiation of myeloid-derived suppressor cells (MDSCs) in the bone marrow (BM) under inflammatory conditions. In this study, we aimed to investigate the signaling pathway involved. RNA-seq revealed that the mitogen-activated protein kinase (MAPK) pathway exhibited the highest number of upregulated genes in MSC-induced MDSCs. Western blot analysis confirmed the strong phosphorylation of c-Jun N-terminal kinase (JNK) in BM cells cocultured with MSCs under granulocyte-macrophage colony-stimulating factor stimulation, whereas p38 kinase activation remained unchanged in MSC-cocultured BM cells. JNK inhibition by SP600125 abolished the expression of Arg1 and Nos2, hallmark genes of MDSCs, as well as Hif1a, a molecule mediating monocyte functional reprogramming toward a suppressive phenotype, in MSC-cocultured BM cells. JNK inhibition also abrogated the effects of MSCs on the production of TGF-β1, TGF-β2 and IL-10 in BM cells. Furthermore, JNK inhibition increased Tnfa expression, while suppressing IL-10 production, in MSC-cocultured BM cells in response to lipopolysaccharides. Collectively, our results suggest that MSCs induce MDSC differentiation and promote immunoregulatory cytokine production in BM cells during inflammation, at least in part, through the activation of the JNK–MAPK signaling pathway.
Autophagy Markers Are Altered in Alzheimer’s Disease, Dementia with Lewy Bodies and Frontotemporal Dementia
Authors: Longobardi Antonio , Catania Marcella , Geviti Andrea , Salvi Erika , Vecchi Elena Rita , Bellini Sonia , Saraceno Claudia , Nicsanu Roland , Squitti Rosanna , Binetti Giuliano , Di Fede Giuseppe , Ghidoni Roberta
Published: January 2024

The accumulation of protein aggregates defines distinct, yet overlapping pathologies such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). In this study, we investigated ATG5, UBQLN2, ULK1, and LC3 concentrations in 66 brain specimens and 120 plasma samples from AD, DLB, FTD, and control subjects (CTRL). Protein concentration was measured with ELISA kits in temporal, frontal, and occipital cortex specimens of 32 AD, 10 DLB, 10 FTD, and 14 CTRL, and in plasma samples of 30 AD, 30 DLB, 30 FTD, and 30 CTRL. We found alterations in ATG5, UBQLN2, ULK1, and LC3 levels in patients; ATG5 and UBQLN2 levels were decreased in both brain specimens and plasma samples of patients compared to those of the CTRL, while LC3 levels were increased in the frontal cortex of DLB and FTD patients. In this study, we demonstrate alterations in different steps related to ATG5, UBQLN2, and LC3 autophagy pathways in DLB and FTD patients. Molecular alterations in the autophagic processes could play a role in a shared pathway involved in the pathogenesis of neurodegeneration, supporting the hypothesis of a common molecular mechanism underlying major neurodegenerative dementias and suggesting different potential therapeutic targets in the autophagy pathway for these disorders.
Recent Advances in the Diagnosis, Pathogenesis, and Management of Myxoinflammatory Fibroblastic Sarcoma
Authors: Nishio Jun , Nakayama Shizuhide , Aoki Mikiko
Published: January 2024

Myxoinflammatory fibroblastic sarcoma (MIFS) is an infiltrative, locally aggressive fibroblastic neoplasm of intermediate malignancy that typically arises in the distal extremities of middle-aged adults. It can histologically be confused with a number of benign and malignant conditions. Recently, high-grade examples of MIFS have been described. Immunohistochemistry plays a very limited role in the diagnosis of MIFS. Several genetic alterations have been identified in MIFS, including a t(1;10)(p22;q24) translocation with TGFBR3 and/or OGA rearrangements, BRAF rearrangement, and VGLL3 amplification. Although it appears that VGLL3 amplification is the most consistent alteration, the molecular pathogenesis of MIFS remains poorly understood. A wide resection is considered the standard treatment for MIFS. Radiotherapy may be a viable option in cases with inadequate surgical margins or cases where surgery is likely to cause significant functional impairment. The systemic treatment options for advanced or metastatic disease are very limited. This review provides an updated overview of the clinicoradiological features, pathogenesis, histopathology, and treatment of MIFS.
Role of Epigenetics for the Efficacy of Cisplatin
Authors: Lumpp Tatjana , Stößer Sandra , Fischer Franziska , Hartwig Andrea , Köberle Beate
Published: January 2024

The clinical utility of the chemotherapeutic agent cisplatin is restricted by cancer drug resistance, which is either intrinsic to the tumor or acquired during therapy. Epigenetics is increasingly recognized as a factor contributing to cisplatin resistance and hence influences drug efficacy and clinical outcomes. In particular, epigenetics regulates gene expression without changing the DNA sequence. Common types of epigenetic modifications linked to chemoresistance are DNA methylation, histone modification, and non-coding RNAs. This review provides an overview of the current findings of various epigenetic modifications related to cisplatin efficacy in cell lines in vitro and in clinical tumor samples. Furthermore, it discusses whether epigenetic alterations might be used as predictors of the platinum agent response in order to prevent avoidable side effects in patients with resistant malignancies. In addition, epigenetic targeting therapies are described as a possible strategy to render cancer cells more susceptible to platinum drugs.