bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Pelatihan Petugas Pemeriksa Jalur Rel Kereta Api (PPJ) di BPTP Sofyan Hadi
Authors: Alivya Reyna Rizky , Suprayekti Suprayekti
Published: March 2020

Penelitian ini bertujuan untuk mendeskripsikan implementasi pelatihan petugas pemeriksa jalur rel kereta api (PPJ) di Balai Pelatihan Teknik Perkeretaapian (BPTP)  Sofyan Hadi sesuai dengan komponen pelaksanaan pelatihan Blanchard dan Thacker yang terdiri dari instruktur pelatihan, alat dan bahan pelatihan, fasilitas pelatihan, dan media pelatihan. Penelitian ini merupakan penelitian deskriptif. Pengumpulan data dilakukan dengan observasi, kuesioner, dan wawancara. Observasi dilakukan untuk mengamati proses pelaksanaan pelatihan, kuesioner disebarkan kepada peserta pelatihan PPJ sebagai responden yang terlibat aktif dalam pelatihan, serta wawancara dilakukan kepada penyelenggara pelatihan yaitu pihak BPTP Sofyan Hadi. Hasil dari penelitian menunjukan bahwa implementasi pelatihan PPJ di BPTP Sofyan Hadi dapat dikategorikan â€œbaikâ€ pada komponen instruktur pelatihan, alat dan bahan pelatihan dan fasilitas pelatihan, sedangkan pada komponen media pelatihan dikategorikan â€œsangat baikâ€. Implikasi hasil penelitian ini adalah dapat dijadikan bahan pertimbangan guna meningkatkan kualitas pelaksanaan pelatihan PPJ berikutnya di perusahaan.
Pengembangan Buku Panduan Kredit pemilikan Rumah Subsidi di PT. Tata Bangun Sarana
Authors: Mulyani Sharah , Suprayekti Suprayekti , Widyaningrum Retno
Published: March 2020

Abstract 

____________________________________________________________________

Penelitian pengembangan ini bertujuan menghasilkan buku panduan kredit pemilikan rumah subsidi yang dapat digunakan secara mandiri oleh konsumen di PT Tata Bangun Sarana. Penggunaan buku panduan kredit pemilikan rumah subsidi ini diharapkan mampu membantu konsumen dalam melalui tahapan pengajuan kredit dari tahap booking fee, melengkapi formulir persyaratan, wawancara, observasi/survei sampai dengan proses akad kredit. Penelitian ini menggunakan model pengembangan dari Rowntree yang melalui tiga tahapan yaitu (1) Tahap Perencanaan (2) Tahap Penulisan (3) Tahapan Penulisan dan Penyuntingan. Produk dievaluasi dengan menggunakan evaluasi formatif. Evaluasi formatif yaitu melalui uji coba ahli materi dan ahli media. Hasil yang diperoleh dari uji coba ahli materi adalah 3,7 sedangkan hasil uji coba ahli media adalah 3,37.  Evaluasi juga dilakukan kepada konsumen melalui beberapa tahapan yaitu uji coba one to one yang memperoleh hasil 3,56. Kemudian uji coba Small Group Evaluation memperoleh hasil 3,64. Hasil keseluruhan dari semua tahapan uji coba adalah pengembangan buku panduan kredit pemilikan rumah subsidi sudah sangat baik. Buku panduan ini dapat membantu konsumen.

Abstract

The purpose of this developmental research is to produce mortgage subsidy guide books that can be studied independently by consumers in PT. Tata Bangun Sarana. The use of mortgage subsidy guide books expected to assist in filing stage through credit, from the stage of  the booking fee, complete the requirement forms, obervation/survey, until the process of the contract credit. The research uses development model from Rowntree through three stage: (1) Planing Stage (2) Stages of Writing (3) Stages of Writing and Editing. Product are evaluated using formative. Formative evaluation is through the trial of material experts and media experts. The results obtained from a material expert trial is 3,7 while the trial results a media expert is 3,37. Evaluation is also conducted for consumer through several stages of one-to-one trial results 3,56. Then small group evaluation trial result is 3,54. The overall results from all of the trials are the development of mortgage subsidy guide books is already very good.
Prevalence of Depression Among Osteoarthritis Clients in Baguio City
Authors: Bucsit Ciarra O. , Pulido Florence L. , Agad Dulcie Amor B. , Agustin Charles Fred B. , Balegan Nikki P. , Belino John Gabriel A. , Boado Sharmaine Khaye O. , Esalley Jaedlyn P. , Juico Gizelle Anne D. , Mordenio Jobelle D. , Navarro Giulia Ariela P. , San Andres Marie Rosario M. , Taal Carmelle Joy R.
Published: March 2020

Osteoarthritis (OA) is a degenerative and non-inflammatory disorder of movable joints. Depression may be a reaction to pain in osteoarthritis (Romano, 2013). The study aims to determine the prevalence of depression among OA clients by determining the degree of depression and a significant difference in depression according to some factors. Purposive, convenience and quota sampling were used. 3 respondents were taken per barangay of 129 barangays in Baguio City. Responses were tallied and subjected to a percentage, t-test, and f-test. The degree of depression of OA clients is normal ups and downs with 191/351(54.42%) respondents. Results show significant differences with genetics and history of bone injury to depression of OA clients and no significant differences as to age, sex, BMI, co-morbidity, occupation, history of joint injury and congenital deformities. There are individuals classified as “clinically depressed”, implying that although results are statistically insignificant, it is clinically significant. Discussions on the management of OA should be holistic and integrated into the curriculum. Nurses should individualize care for OA clients because of their different biopsychosocial effects.
Error Analysis of Interoffice Correspondence of Selected MSU Offices
Authors: Velasco Eugenia A.
Published: March 2020

The study attempted to perform an error analysis, that is to identify and analyze the linguistics errors found in the four (4) corpora of interoffice correspondence which consist of memorandums, special orders, cover letters, and endorsements of the three (3) selected offices of the Mindanao State University, Marawi City, namely, Office of the President, Office of the Vice-Chancellor for Academic Affairs, and the Graduate School during the calendar year 2005, 2006. This paper used the qualitative-descriptive method. To reveal the anticipated outcomes the inductive data analysis was employed. When all of the sources were gathered, the individual texts were subjected to error analysis primarily focused on linguistic errors. These errors were categorized first as local and global errors, and to render error taxonomy more specific for analytic purposes, local and global errors were further classified into three linguistic categories, namely, lexical, syntactic, and morphological. The findings of this study show that the errors found in the corpora of interoffice correspondence are manifestations that even at their level, writers of the said communications are not free from committing these errors. However, these errors were attributed to Other Errors for they could not be readily pigeonholed; they could very well be developmental, interlingual, or ambiguous errors. They could not be due to lack of competence since these communications were written by professionals who have been using the language, hence, warranting the confidence or assumption that they have enough exposure to it.
Geographically weighted regression modelling of the spatial association between malaria cases and environmental factors in Cameroon.
Authors: Tewara Marlvin Anemey , Yunxia Liu , Lin Weiqiang , Barong Binang Helen , Mbah-Fongkimeh Prisca Ngetemalah , Zhaolei Zheng , Xinhui Liu , Miao Zhou , Liu Xiaojuan , Xue Fuzhong
Published: March 2020

Background: Studies have illustrated the association of malaria cases with environmental factors in Cameroon but limited in addressing how these factors vary in space for timely public health interventions. Thus, we want to find the spatial variability between malaria hotspot cases and environmental predictors using Geographically weighted regression (GWR) spatial modelling technique.Methods: The global Ordinary least squares (OLS) in the modelling spatial relationships tool in ArcGIS 10.3. was used to select candidate explanatory environmental variables for a properly specified GWR model. The local GWR model used the global OLS candidate variables to examine, predict and explore the spatial variability between environmental factors and malaria hotspot cases generated from Getis-Ord Gi* statistical analysis. Results: The OLS candidate environmental variable coefficients were statistically significant (adjusted R2 = 22.3% and p < 0.01) for a properly specified GWR model. The GWR model identified a strong spatial association between malaria cases and rainfall, vegetation index, population density, and drought episodes in most hotspot areas and a weak correlation with aridity and proximity to water with an overall model performance of 0.243 (adjusted R2= 24.3%).Conclusion: The generated GWR maps suggest that for policymakers to eliminate malaria in Cameroon, there should be the creation of malaria outreach programs and further investigations in areas where the environmental variables showed strong spatial associations with malaria hotspot cases.
Knowledge on Genetic and Genomic Diagnostics among Sri Lankan Medical Practitioners
Authors: Jayawardana Sinhalage Mahesh Asantha
Published: March 2020

Objectives : Up-to-date knowledge on changing genetic and genomic diagnostic approaches is essential for a contemporary medical practitioner. This study was carried out to describe Sri Lankan Medical Practitioners’ current knowledge and opinion on modern genetic and genomic diagnostics techniques.
Results : Data was collected to an electronic database using an online self-administered questionnaire. A total of 123 respondents completed the questionnaire. Majority had either some or adequate knowledge on applications of basic genetic diagnostic methods such as karyotyping and polymerase chain reaction. Similarly most had either some or adequate knowledge on the use of predictive genetic tests in cancer. However the level of knowledge on the applications of modern diagnostic techniques like Fluorescent in-Situ Hybridization and Next Generation Sequencing remained poor. Majority had inadequate knowledge on newer concepts such as direct-to-consumer genetic testing and personalized medicine. Most agreed upon the inadequacy of undergraduate genetic education and the need of a continuous medical education program to fill this knowledge gap. Both undergraduate and continuous medical education approaches should be modified to improve the knowledge on increasingly complicated technological and ethical aspects associated with modern genetic diagnostics.
Loss of HtrA2/Omi protease activity induces mitonuclear imbalance and sarcopenia via differential regulation of mitochondrial biogenesis
Authors: Zhou Haohan , Yuan Danni , Gao Weinan , Tian Jiayi , Sun Hongyu , Yu Shuang , Sun Liankun , Wang Jincheng
Published: March 2020

The authors have withdrawn this preprint from Research Square
Prevalence of Primary Headache Disorders among Information Technology Staff in China: The Negative Effects of Computer Use and Other Correlative Factors
Authors: Li Chunlin , Zhang Lei , Zhou Jin , Fan zhiliang , Wang Yan , Wang Xiaolin , Wang Weidong , yu shengyuan
Published: March 2020

Background

To date, there have been very few studies that have explored the relationship between headaches and computer use. The chief aim of this study is to investigate the prevalence of primary headache disorders among informational technology staff and identify the potential factors contributing to it.

Methods

This is a cross-sectional study based on annual health checks of employees from the information technology industry. We identified 2216 information technology staff members from Beijing by stratified random sampling who met the inclusion criteria. All participants were initially required to have a physical examination, after which they complete a general situation questionnaire that included a headache screening question. Those who had suffered from headache within the previous year also completed the questionnaire developed by Lifting the Burden. The International Classification of Headache Disorders 3(ICHD-3) criteria was used for the diagnosis of headache.

Results

A total of 2012 valid questionnaires (males, 1544; females, 468) were obtained from 2216 participants for a response rate of 90.8%. A total of 619 participants were diagnosed with primary headache, the one-year prevalence of which was 30.8%. Regarding the classification of the primary headache, 152 participants suffered from migraine, with a one-year prevalence of 7.6%; 440 and 27 suffered from tension-type headache and unclassified headaches, with one-year prevalences of 21.9% and 1.3%, respectively. Multivariate regression analysis showed that female gender was a risk factor for migraine and tension-type headache (OR 3.21 and 1.88, respectively). Age was also related to migraine and tension-type headache. The 41-50 age group had 2.02 times the probability of migraine, and the 31-40 age group had 1.89 times the probability of tension-type headaches compared to the 18-30 age group. Obesity and excessive computer use (more than 12 hours per day) were also factors contributing to tension-type headache (OR: 2.61 and 1.63, respectively).

Conclusions

The one-year prevalence of primary headache in this population was 30.8%. The prevalence of tension-type headache in this population was higher than that in the general Chinese population. The occurrence of primary headache is correlated with many factors, among which excessive computer use significantly contributed to the risk of tension-type headache.
Detection of copy number variants in African goats using whole genome sequence data
Authors: Nandolo Wilson , Mészáros Gábor , Wurzinger Maria , Banda Liveness J. , Gondwe Timothy N. , Mulindwa Henry A. , Nakimbugwe Helen N. , Clark Emily L. , Woodward-Greene M. Jennifer , Liu Mei , Liu George E. , Tassell Curtis P. Van , Rosen Benjamin D. , Sölkner Johann
Published: March 2020

BackgroundCopy number variations (CNV) are a significant source of variation in the genome, as such they are essential to the genetic characterization of animal breeds. The aim of this study was to develop a fine-scaled copy number variation map for African goats. We used sequence data from multiple breeds and from multiple African countries. ResultsA total of 253,553 CNV (244,876 deletions and 8,677 duplications) were identified, corresponding to an overall average of 1,393 CNV per animal. The mean CNV length was 3.3 kb, with a median of 1.3 kb. There was substantial differentiation between the populations for some CNV, suggestive of the effect of population-specific selective pressures. A total of 6,231 global CNV regions (CNVR) were found across all animals, representing 59.2 Mb (2.4%) of the goat genome. About 1.6% of the CNVR were present in all 34 breeds and 28.7% were present in all 5 geographical areas across Africa, where animals had been sampled. The CNVR had genes that were highly enriched in important biological functions, molecular functions, and cellular components including retrograde endocannabinoid signaling, glutamatergic synapse and circadian entrainment. ConclusionsThis study presents the first fine CNV map of African goat based on WGS data and adds to the growing body of knowledge on the genetic characterization of goats.
Oral metoclopramide boosts lactogenesis II in mothers with preterm infants: a randomized placebo-controlled trial.
Authors: Fok Doris , Chan Yiong Huak , Ho Jiahui , RAuff Mary HJ , Chan Yah Shih , Chong Yap Seng , Mattar Citra NZ
Published: March 2020

Background: Preterm mothers at risk of delayed lactogenesis II may benefit from early pharmcological intervention to initiate breastfeeding onset. Research aim. To evaluate the effect of oral metoclopramide on lactogenesis II in mothers of preterm infants commencing within twelve hours of delivery. Methods: From April 2006 to May 2009,105 women were randomized to metoclopramide (term births, n=36;reterm n=20) or placebo (term,n=33;preterm,n=16). Mothers received 30 mg of oral metoclopramide daily for the first postnatal week in a randomized double-blinded placebo-controlled study. Primary outcome was augmentation of Lactogenesis II onset by postnatal day 3. Secondary outcomes were daily expression of breastmilk and maternal perception of lactogenesis II, breastfeeding practice and infant weight change over 6 months. Results: Metoclopramide achieved 25% augmentation in lactogenesis II onset (p=0.09) with greater expressed human milk volumes in mothers of preterm infants. Daily expressed human milk volumes was higher among preterm mothers on metoclopramide compared to term placebo mothers who served as controls, significant on day 2 (19.9 vs 2.4ml, p=0.04) and day 3 (32.6 vs 8.8ml,p=0.04),and total expressed human milk volumes had increased by 8.2 fold by the end of week one. Most mothers reported first initiation of lactogenesis II by day 6, with 95-100% of term mothers confirmed by day 5 (not significant). Conclusions: Short-term metoclopramide use starting within 12 postnatal hours boosted lactogenesisi II onset in preterm mothers, improving daily expressed human milk production and maternal perception of lactogenesis II onset.
Trends and Predictors of underweight among under-five children in Ethiopia, based on Ethiopian Demographic and Health Survey 2005 -2016. Multivariable Decomposition analysis
Authors: Birhan Tilahun Yemanu , Angaw Dessie Abebaw
Published: March 2020

Background Underweight is one of the paramount major worldwide health problems, and it touches a large number of population from infancy to old age. This study aimed to analyze the trends and predictors of change in underweight among under-five children in Ethiopia Method The data for this study were accessed from three Ethiopian Demographic and Health Surveys data set 2005, 2011 and 2016. The trend was examined separately for the periods 2005–2011, 2005-2016, and 2011-2016. Multivariate decomposition analysis of change in underweight was employed to answer the major research question of this study. The technique employed the output from the logistic regression model to parcel out the observed difference in underweight into components, and STATA 14 was utilized for data management and analysis. Result Among children in Ethiopia the prevalence of underweight declined from 38% in 2005 to 25% in 2016. The decomposition analysis indicated that almost half of the overall change in underweight was due to difference in characteristics. Change in the composition of parental education, wealth index, duration of breastfeeding, respondents’ occupation, was the major contributor for the decline of underweight, while the age of child and presence of diarrhea were contributors for the rise of underweight in Ethiopia. Conclusion underweight shows a remarkable decline over the last decades in Ethiopia. Change in composition of Birth size, duration of breastfeeding, household wealth quantile (richer) and husband/partner primary education are attributable to the decline of underweight.
Examining Trends in Sepsis and Sepsis Management by Non-Physician Clinicians in a Rural Ugandan Emergency Department Over a Decade.
Authors: Calo Sal , Rice Brian Travis , Kamugisha John Bosco , Kamara Nicholas , Chamberlain Stacey
Published: March 2020

Background: There is a paucity of data from Sub-Saharan Africa regarding sepsis outcomes and the impact of sepsis care on those outcomes, including the impact of care provided by non-physician clinicians (NPCs). Methods: Data were retrospectively analyzed from a rural Ugandan emergency department staffed by NPCs using a quality assurance database of adult and pediatric patient visits with and without sepsis from 2010 through 2018. Sepsis was defined as suspected infection with a qSOFA score ≥ 2. Mortality, disposition, and NPC adherence to intravenous fluid and anti-infective therapy were analyzed using chi-squared and multivariable linear regression. Results: Sepsis criteria were met in 4,847 (11.0%) cases. Sepsis cases compared to non-sepsis cases were significantly older, and had higher rates of comorbid malaria, HIV, tuberculosis, and pneumonia. They had higher admission rates (86.8% versus 66.3%), were more likely to still be admitted at three days (40.2% versus 26.2%), and had higher mortality at three days (7.8% versus 2.5%). The incidence of sepsis significantly declined over time from 16.3% in 2010 to 3.1% in 2018 while the proportion of sepsis cases with qSOFA score of ≥ 3 increased significantly over time. The decrease in incidence was largely due to a precipitous drop in malaria smear-positive sepsis. Utilizing a multivariable linear regression model, annual three-day sepsis mortality did not significantly change over time, though adherence to administration of both fluids and anti-infectives increased significantly from 12.3% in 2010 to 35.0% in 2018. Conclusions: Sepsis incidence, especially malaria smear-positive sepsis, decreased over time, while annual mortality did not change despite increased adherence to administration of anti-infectives and intravenous fluids in an NPC-staffed emergency department. Further studies are needed to investigate the contextualized use of anti-infectives and fluid resuscitation.
Two SNPs (rs1801282 and -1279G/A) of PPARγ are associated with Parkinson's disease in a northern Chinese population
Authors: li shanshan , Xue Li , Wang Huimin , Tian Qingwu , Xie Anmu
Published: March 2020

Background: This study aimed to assess the association between PPARγ gene polymorphism and susceptibility to Parkinson’s disease (PD) in a northern Chinese population.
Methods : We conducted a case-control study which including 391 outpatients with PD and 391 healthy matched individuals. All subject genotypes on PPARγ gene in rs3856806, rs1801282, -1279G/A were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.
Results : Our results showed participants with AG and AG+AA (dorminant model) genotypes of -1279G/A had a higher genetic risk of PD compared to those with GG ( p = 0.024, OR = 1.781, 95% CI = 1.073-2.956; p = 0.024,OR = 1.768, 95% CI = 1.078-2.898). A allele of the -1279G/A polymorphism was presumably correlated with increased risk of PD ( p = 0.037,OR = 1.639, 95% CI = 1.027-2.616) and male PD ( p =0.032, OR = 1.998, 95% CI = 1.051-3.798) as well as early-onset Parkinson’s disease (EOPD)( p =0.019, OR = 2.667, 95% CI = 1.263-5.629). Stratification analysis by age for rs1801282 indicated a significant genotype difference between EOPD and controls( p =0.005) as well as late-onset Parkinson’s disease(LOPD) and controls( p =0.008). G allele frequency of rs1801282 in EOPD subjects was significantly higher than it in controls( p = 0.006, OR =3.093, 95% CI = 1.446-6.615) and LOPD ( p = 0.009, OR =2.899, 95% CI = 1.344-6.253).
Conclusions : The study showed that in a northern Chinese population, the A allele of -1279G/A might be a risk factor for PD and the G alle of rs1801282 might increase the susceptibility of EOPD.
Heightened sensitivity to low-level visual information in autism during an emotional attentional blink task
Authors: Lacroix Adeline , Gomot Marie , Fombonne Margot , Perrier Mickaël J. R. , Peyrin Carole , Vermeulen Nicolas , Park Gewnhi , Dutheil Frédéric , Mermillod Martial
Published: March 2020

Background Impairments in facial emotion recognition have been a hallmark of autism, which may contribute to the difficulty in social engagement and interpersonal interaction. Impaired facial emotion recognition in autism could be partly due to the asymmetrical perceptual bias to High Spatial Frequencies (HSF) information observed during visual perception. While Low Spatial Frequencies (LSF) convey coarse information, which would be critical for a fast analysis and categorization of emotional faces, HSF convey local information, which may serve a critical role in visual consciousness. However, to our knowledge, the effect of HSF on visual consciousness in autism has not been specifically studied so far. Methods Thirty-three adult autistic participants and 35 typically developing (TD) control participants performed an emotional attentional blink paradigm. Participants had to identify and report two targets (happy faces, T1 and T2) embedded in a stream of distractors (angry faces). The distractors between T1 and T2 were unfiltered or filtered in HSF or LSF. We used ANOVA to compare the impact of spatial frequency information on visual consciousness in the two groups of participants. Results TD control participants showed significantly reduced T2 accuracy (i.e., accuracy for the second target given the correct report of the first target T1) after unfiltered and HSF distractors compared to LSF distractors. As predicted, reduced T2 accuracy was observed after HSF distractors in the autistic group as compared to the TD group. Although we did not hypothesized, we also found reduced T2 accuracy after LSF distractors in the autistic group. The accuracy between the two groups did not differ regarding unfiltered distractors. Limitations Our sample was adult, high functioning and mainly late diagnosed. Therefore, our findings may not generalize to the whole autistic population. Conclusion Results confirm that HSF plays a critical role in visual consciousness in both TD and autistic participants. More importantly, autistic participants demonstrated impaired target detections after filtered distractors, suggesting that they have enhanced sensitivity for low-level characteristics, such as high and low spatial frequencies filtering. These findings are discussed in the context of the Enhanced Perceptual Functioning theory and predictive coding frameworks.
Cerebral Activation Patterns Of Older Adults While Performing The Functional Gait Test
Authors: Tavares Larissa Bastos , Souza Idaliana Fagundes de , Filho Bartolomeu Fagundes de Lima , Yano Kim Mansur , Gazzola Juliana Maria , Vieira Edgar Ramos , Cavalcanti Fabricia Azevedo da Costa
Published: March 2020

Dual-task activities are common in daily life and have greater motor/cognitive demands. These are conditions that increase the risk of older adult falls. Falls are a public health problem. Brain mapping during dual-task activities can inform which therapeutic activities stimulate specific brain areas, improving functionality, and decreasing dependence and the risk of falls. The objective of the study was to characterize the brain activity of healthy older adults while performing a dual-task activity called the Functional Gait Test (FGT). Method : This observational study included 30 older adults aged 65 to 75 years, and it was approved by the institutional review board. The FGT consists of walking following a sequence of numbers (simple task), and a sequence of alternating letters and numbers (complex task). During the activity, the subjects had their cortical activation pattern measured using the Emotiv EPOC® electroencephalogram. Complete data was obtained for analysis on 13 participants. The data was analyzed using descriptive statistics (mean and standard deviation), and paired T-tests to compare the brain activity during the conditions (simple vs. complex task). Results : Alpha brain waves were activated in the right and left hemispheres during the simple task, while Alpha brain waves’ activation during the complex task was predominant in the right hemisphere. However, the differences were not statistically significant. The Betha waves had predominant activation in the left hemisphere during the simple task, and predominant activation in the right hemisphere during the complex task. The difference was statistically significant in 11 out of the 14 channels evaluated ( P <0.04). Conclusion: The results corroborates the increased complexity of dual-tasks due to the predominant activation of the right hemisphere, which is related to motor learning process and new stimulus processing.
Physical activity and the prevalence of primary headaches among a large population of university students: The MEPHASOUS study
Authors: Mansouri Masoume , Sharifi Farshad , Varmaghani Mehdi , Shokri Azad , Rahdar HosseinAli , Keshtkar Abasali , Sadeghi Omid
Published: March 2020

Background: Primary headaches have a high prevalence among university students. Lifestyle has an important role in the prevention and management of these headaches. Among lifestyle factors, data on the association between physical activity and primary headaches are scarce and conflicting.Aim: To examine the association between physical activity and primary headaches among a large population of university students.Methods: Totally, 83,463 university students from 28 provinces of Iran were included in the current cross-sectional study. Data on physical activity, dietary intakes, and demographic characteristics were collected using pre-tested questionnaires. Primary headaches were determined according to the International Classification of Headache Disorders-3 (ICHD-3) criteria.Results: Mean age of university students was 21.50 ± 4.01, and 54.7% were female. Primary headaches were prevalent among 9% of students. A significant inverse association was seen between physical activity and primary headaches in the whole population (OR: 0.66, 95% CI: 0.62-0.71). Such an inverse association was also observed after taking potential confounders into account; such that students who were physically active had 21% lower odds of primary headaches compared with those who were physically inactive (OR: 0.79, 95% CI: 0.72-0.87). Also, physical activity was associated with reduced odds of primary headaches in male and female students (Males; OR: 0.70, 95% CI: 0.60-0.82, females; OR: 0.84, 95% CI: 0.75-0.94) as well as those students with normal-weight (OR: 0.79, 95% CI: 0.71-0.87), overweight, or obesity (OR: 0.80, 95% CI: 0.66-0.96).Conclusion: Our findings support the protective association between physical activity and primary headaches.
Exercise-Based and Associated Factors Breastfeeding on HIV-Infected Mothers for Children Age 1-﻿24 Months in Central Zone, Tigray, North Ethiopia, 2019.
Authors: Embaye Hamelmal Mekonen , Gebremeskel Teferi Gebru
Published: March 2020

Background: Breastfeeding exposed to HIV is a major factor in the spread of HIV, but breastfeeding alone poses a significant risk to the baby's health because breastfeeding can reduce the impact of many infections and support some chronic diseases. Therefore, this study was aimed to assess exercise-based and associated factors breastfeeding on HIV-infected mothers for children age 1-24 months in the central zone, Tigray, north Ethiopia. Methods: A Facility-based Cross-Sectional study was conducted from March to April 2019. A systematic random sampling method was used to select study participants. Information was collected using a structured, pre-tested questionnaire. The data is coded, cleaned, copied and entered EPI-info 7 and finally export to SPSS version 22.00 for analysis. Association between independent and dependent variables was first analyzed using binary logistic regression analyses. An alternative bivariate logistic regression analyzes of less than 0.2 were entered in multivariable logistic regression analysis. The statistical association between variance dependent and independent variables was measured using an OR, AOR, 95% CI, and a p-value less than 0.05. Result: 239 HIV-positive mothers participated in this study. Approximately 204(85.4) are favorable attitude in the practice of exclusive breastfeeding. The majority of mothers 206 (86.7%) experienced good breastfeeding. Mothers with Information while exclusive breastfeeding (AOR, 2.57, 95%CI: 1.03- 6.4) and age at first birth (AOR: .247, 95%: (.106- .578) had a significant collaboration on exclusive breastfeeding practice among HIV-infected mothers. Several ANC visits have had a significant collaboration on exclusive breastfeeding practice among HIV-infected mothers (AOR; 3.726 95%CI; 1 .055-13.154).Conclusion: The study found that HIV positive mothers attending health care facilities had a favorable attitude but practiced on EBF is still low. Therefore, train health professionals especially health extension workers to raise awareness education, enhance information, regarding EBF and strength counseling in ANC service is better to improve the HIV positive mother level of attitude and practice to EBF.
The cerebrospinal fluid changes and clinical characteristics of aseptic meningitis in Kawasaki disease
Authors: Hu Fan , Shi Xiaoqing , Fan Yang , Liu Hanmin , Zhou Kaiyu
Published: March 2020

Background: Aseptic meningitis is not a common feature in Kawasaki disease (KD). However, it could cause difficulty in making correct and in-time diagnosis Methods: We retrospectively investigated patients of KD and bacterial meningitis (BM). Totally 38 KD patients and 126 BM patients were brought into this study. Clinical symptoms, signs and laboratory examinations were compared between the two groups, which included: duration of fever before lumbar puncture, conjunctiva injection, oral cavity change, rash, cervical lymphadenopathy and extremities change, vomiting, front fontanel bulging, neck stiffness, leukocytes, hemoglobin, platelets, C-reactive protein, cerebrospinal fluid examinations, liver function and urinalysis. Results: In clinical signs, vomit and neck stiffness were more prevalent in BM. KD patients showed higher blood leukocyte (p<0.001) and C-reactive protein (p<0.001) in the early febrile stage. Glucose in cerebrospinal fluid of BM patients was significantly lower than KD patients (p=0.003). In ROC curve, the optimal cutoff value of CSF glucose was 2.945mmol/L with the sensitivity of 84.2% and specificity of 71.4%. Pyuria was more prevalent in KD patients (p<0.001). There was no significant difference in front fontanel bulging, hemoglobin, platelet, alanine transaminase, aspartate transaminase, albumin, cerebrospinal fluid leukocytes, cerebrospinal fluid protein and cerebrospinal fluid lactate dehydrogenase. Conclusions ： Full investigation of clinical manifestation and laboratory tests is necessary to distinguish KD with aseptic meningitis and BM. In CSF study, glucose level is more efficient than other items to distinguish these two diseases. Decreased CSF glucose is possibly an indicator of BM rather than KD.
Role of Serum Fatty Acids in Children with Henoch-Schönlein purpura by GC-MS analysis
Authors: Wen Min , feng shipin , dang xiqiang , ding xuewei , xu zhiquan , huang xiaoyan , lin qiuyu , xiang wei , he xiaojie
Published: March 2020

BACKGROUND: The objectives of this work were to discover the changes of serum Medium- and Long-Chain fatty acids levels and its possible relationship with Henoch-Schönlein Purpura (HSP), also referred to as Immunoglobulin A vasculitis in children. METHODS: A total of 58 children with HSP and 28 healthy children were recruited for this study. Serum fatty acids were analyzed by gas chromatography with mass spectrometry (GC-MS). RESULTS: 31 species of Fatty acids were discovered to have a significant difference between HSP group and healthy control group (CON group). The contents of all detected 37 fatty acids in the HSP group were higher than the healthy group. Parts of fatty acids were found in our study having significant change according to the treatment. Palmitate (C16:0) and 18 carbon atoms (C18) of fatty acids were abundant in all three groups of HSP. Elaidate (C18:1T), cis-11,14,17-Eicosatrienoic acid ester (C20:1) and cis-15-tetracosenoate (C24:1) were found to have a correlation on renal damage of HSP. CONCLUSION: Our study provides clinical evidence to support that fatty acid metabolism is associated with HSP by GC-MS method. Glucocorticoid therapy has a certain relationship with fatty acid metabolism during HSP treatment. Meanwhile, long-chain MUFAs may have an impact on renal damage of HSP. In addition, we speculate that a low BMI may be a kind of manifestation of abnormal fatty acid metabolism in HSP. All in all, further study is needed to explore the specific mechanism of fatty acids and HSP.
Retrospective analysis of dendriform pulmonary ossification: Possible involvement of inflammation and hemorrhage
Authors: Enomoto Takatoshi , Takimoto Takayuki , Kagawa Tomoko , Tachibana Kazunobu , Sugimoto Chikatoshi , Arai Toru , Sakurai Teiko , Kasai Takahiko , Akira Masanori , Hayashi Seiji , Inoue Yoshikazu
Published: March 2020

BackgroundDendriform pulmonary ossification (DPO) is a rare condition characterized by metaplastic bone formation in the lung parenchyma. DPO has been reported to be often associated with usual interstitial pneumonia (UIP) or chronic aspiration of gastric acid; however, DPO is believed to be a multifactorial disease, and its clinical features and pathophysiology remain unclear. This study aimed to reveal the novel clinical features and pathophysiology of DPO.MethodsThe pathology reports of consecutive cases diagnosed by surgical lung biopsy for diffuse lung diseases (DLDs) between April 1, 2000 and March 31, 2018 were reviewed retrospectively. Cases showing ossification in their specimens were subsequently reviewed and confirmed as calcified density lesions on CT scans. Besides the definite DPO cases, two DPO cases that involved surgical resection of the lung tumor were also included in the study. The clinical, radiological, and pathological features were analyzed.ResultsThree (0.96 %) out of 313 cases with DLDs were identified as cases of definite DPO. Taken together with the two DPO cases showing lung tumors, five DPO cases were analyzed. The patients were predominantly male, with a median age of 69 years. Four cases showed no smoking history. One patient had gastroesophageal reflux disease and UIP, and another had demonstrable hiatal hernia. Laboratory data were not remarkable. Pulmonary function at baseline was almost normal, and no significant decline was observed during the follow-up period. All cases showed interstitial fibrosis accompanied by ossifications. Intriguingly, the histological examination revealed intra-alveolar fibrosis and slight inflammatory cell infiltration, including new bone formation, corresponding to the consolidation on the CT scan in one case. In addition, consolidation, suspected to be caused by inflammation or hemorrhage, was also noted in two other DPO cases, namely in all of three idiopathic cases without UIP or risk factors for gastric acid aspiration.ConclusionsAll five DPO cases were indolent, indicating that the prognosis of DPO might be good. The pathological and radiological findings suggested the possible involvement of pulmonary inflammation and hemorrhage in the pathogenesis of DPO.
Diffuse sclerosing variant of papillary thyroid carcinoma: a case report
Authors: Wang Siyao , Wang Rui , Sun Ruize , Luo Xiaoman , Xuan Yue , Sun Xiaohan , Li Aoxue , Cong Yilin , Zhang Jiayan , Li Pengcheng , Luo Yuan , Li Ji , Liu Yang
Published: March 2020

Background: The diffuse sclerosing variant of papillary thyroid carcinoma (DSVPC) is a rare variant of papillary thyroid carcinoma with features of strong ability of invasion, metastasis, relapse, and mortality. Its diagnosis is difficult to obtain because of the special differentiation state of the cancer cells. Case Presentation: A 21-year-old woman arrived at the First Affiliated Hospital of China Medical University in October 2019 because of a peach-pit-sized mass that she had noticed 1 month before. Color duplex ultrasonography findings suggested a thyroid nodule. Conclusions: Based on findings of the specialist examination, physical examination, and thyroid ultrasonography, the patient was initially diagnosed with thyroid neoplasm. Under general anesthesia, thyroidectomy was performed, removing the right lobe and isthmus, and biopsy specimens were obtained from lymph node groups III, IV, and VI on the right side. The final histological diagnosis was DSVPC.
Paeonol suppresses invasion, migration, and epithelial-to-mesenchymal transition in colorectal cancer cells through inhibition of COX-2 and PGE2
Authors: Li Ming , Tan Shi-yun , Yu Yuan-jie
Published: March 2020

Purpose: To observe the effects of paeonol on the invasion and migration of LoVo colorectal cancer cells, and investigate its possible mechanisms. Materials and Methods: Cell transwell assay and wound-healing assay were applied, and the results suggested that paeonol could significantly inhibit the invasion and migration abilities of LoVo cells, which was associated with a reduction in COX-2 expression and PGE2 synthesis. Treatment with the selective COX-2 inhibitor, celecoxib, or transient transfection of colorectal cancer cells with COX-2 siRNA, also inhibited cell invasion and migration. Results: The invasion and migration capacity were evaluated in LoVo cells by transwell assay and wound-healing in vitro. Compared with the control group, the invasion cells through Matrigel and the wound-healing rate were significantly decreased after treated with paeonol for 24 h. Paeonol treatment downregulated the expression of MMP-9 and downregulated the COX-2 expression and PGE2 synthesis in LoVo cells. Paeonol could up-regulate the expression of epithelial marker E-cadherin while down-regulate the expressions of mesenchymal markers, Fibronectin and Vimentin. Paeonol inhibited PI3K-Akt and MAPK-ERK pathways in LoVo cells. Celecoxib treatment significantly decreased the cells penetrating the matrigel in a dose-dependent manner. siRNA knockdown of COX-2 leaded to inhibition of cell invasion in LoVo cells. Knockdown of COX-2 increased the expression of E-cadherin, whereas the expressions of Fibronectin and Vimentin were downregulated. Conclusion: Paeonol may inhibit PI3K-Akt and MAPK-ERK pathways through suppressing of the COX-2 expression and PGE2 synthesis, thus inhibiting the cell invasion, migration, and EMT in LoVo cells.
Is There Need a Specific Scoring System for Acute Appendicitis During Pregnancy?
Authors: Mantoglu Baris , Gonullu Emre , Akdeniz Yesim , Yigit Merve , Firat Necattin , Akin Emrah , Altintoprak Fatih , Erkorkmaz Unal
Published: March 2020

BackgroundAcute appendicitis is the most common non-gynecological emergency during pregnancy. The diagnosis of appendicitis during pregnancy is challenging due to both physiological and laboratory changes. As such, the surgeon needs additional guidance, other than imaging methods, before deciding a surgical intervention. Various scoring methods have been defined and evaluated for the diagnosis of acute appendicitis for a long time. There is no definition of a score for the gestation period, and the comparison of the currently applied scoring methods during the gestation period is not available in the literature.The purpose of our study is to evaluate the efficacy of the most popular scoring systems applied in the diagnosis of acute appendicitis in pregnancy and the tips for introduction to a scoring method for the pregnancy period.MethodsThis single-center retrospective study consists of 79 pregnant patients who were admitted to the emergency department with abdominal pain between May 2014, May 2019 and were diagnosed with acute appendicitis and underwent an appendectomy together with 79 non-pregnant control group who underwent appendectomy for the last 1.5 years. Both laboratory and examination findings required for the scoring methods of the patients were obtained and calculated separately for each patient. Negative appendectomy rates were evaluated according to pathology results. Categorical variables were compared by the Chi-Square test. Categorical variables were presented as a count and percentage. A p-value <0.05 was considered significant. Receiver operator characteristic (ROC) curve analysis was used to identify the best cut-off value and assess the performance of the test score for appendicitis.ResultsThe Tzanakis Score is the strongest among the scoring systems used in non-pregnant women. The positive predictive value (PPV = 90.60) of the Tzanakis Score is 90.6% while the negative predictive value (NPV = 46.7) is 46.7%. RIPASA seems to be the strongest among the scoring systems used in pregnant women. While PPV of this scoring method is 94.40%, NPV is 44%, its sensitivity and specificity are 78.46% and 78.57%, respectively.ConclusionsAlthough the RIPASA score is considerable effective in pregnancy in the diagnosis of acute appendicitis among all scoring systems, a specific scoring system is necessitated for the gestation period.
Doctor-patient Communication skills training for Postgraduate majoring in Oncology Radiotherapy
Authors: Liu Guohui , Liu Feng , Wang Chunbo , Lan Tian , E Mingyan
Published: March 2020

Objective: To evaluate the communicative ability of doctor-patient education for postgraduates majoring in oncology radiotherapy, and to discuss the training mode and effect. Methods: From January 1, 2018 to June 1, 2019, clinical interns of oncology radiotherapy in our hospital (all graduate students) were selected as the research subjects and randomly divided into two groups. A total of 60 cancer radiotherapy interns were randomly divided into experimental group (30 persons) and control group (30 persons); CBL teaching model (introducing training of doctor-patient communication skills) is adopted in experimental group, and traditional CBL teaching model is used in control group. After the end of the teaching, the two groups’ teaching effects are evaluated through the combination of examinations and questionnaires. SPSS 19.0 was applied to do statistical analysis, t test and Wilcoxon were used. Results: SEGUE baseline score of experimental group for doctorpatient communication skills is better than that of SEGUE in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The CBL teaching model which introduces training of doctor-patient communication skills in the practical process in cancer radiotherapy division is conducive to develop practitioners’ good doctor-patient communication and interaction skills.
Peri-treatment peripheral blood cell score predicts long-term locoregional progression hazard in oesophageal squamous cell carcinoma after definitive chemoradiotherapy
Authors: Xu Liangyu , Chen Jianzhou , Guo Hong , Huang Ruihong , Guo Longjia , Yu Yuanxiang , Zhai Tiantian , Wu Fangcai , Chen Zhijian , Li Derui , Chen Chuangzhen
Published: March 2020

Background: Prediction of response to chemoradiotherapy is critical for the optimal management of oesophageal cancer, yet it is still an unmet clinical need. This study aims to evaluate the predictive potential of peri-treatment peripheral blood cells (PBC) in disease progression hazard in oesophageal cancer following chemoradiotherapy.Methods: 87 patients with primary oesophageal squamous cell carcinoma were subjected to definitive concurrent chemoradiotherapy in a phase II trial. PBC parameters (haemoglobin, neutrophils, platelets, lymphocytes and monocytes) were collected at 7 time points through the course of radiotherapy. The values of peri-treatment PBC parameters in predicting 3-year cumulative hazard of tumour progression were evaluated.Results: Patients with disease progression displayed distinct distribution patterns of peri-treatment PBC compared to patients without. Greater prediction capabilities for risk of locoregional disease progression were found in PBC collected after the start of radiotherapy compared to their pretreatment counterparts, and in individual parameters rather than cell-to-cell ratios. The most predictive PBC parameters were integrated by summation and designated as a PBC score (PBCS), which further augmented their predictive power. Patients divided according to their PBCS (high vs medium vs low) had significantly different 3-year cumulative hazards of locoregional progression (58% vs 29% vs 7%, P = 0.0017). Multivariate analysis confirmed that PBCS high (HR 12.2, 95%CI 2.0-76.3, P = 0.007) and medium (HR 5.8, 95%CI 1.2-27.7, P = 0.028) are independent indicators of locoregional progression.Conclusion: Peri-treatment PBCS can predict the long-term hazard of locoregional progression after definitive chemoradiotherapy in patients with oesophageal squamous cell carcinoma.