bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrent multifocal urothelial tumor associated with Lynch syndrome: A case report and literature review
Authors: Duarte Ivan Kirche , Taha Raphael , Monteiro Camila Ribeiro Arruda , Azevedo Rodrigo , Stavale João Norberto , Saiovici Samuel
Published: February 2023

Lynch syndrome is a rare pathology triggered by several genetic mutations that predispose individuals to various tumors. Although uncommon, urothelial carcinoma of the upper urinary tract can present with different characteristics. Here, we present the case of a patient with Lynch syndrome who developed a multifocal, recurrent lesion. A young woman with Lynch syndrome underwent screening at 30 years of age. She presented with macroscopic hematuria, underwent a urinary tract ultrasound, and was diagnosed with bladder cancer. The lesion was resected, and after a few years, she presented with a tumor of the right renal pelvis. Subsequently, a laparoscopic radical nephroureterectomy was performed. As the patient had an allergy to iodinated contrast, we continued screening with cystoscopy, urinary tract ultrasound, and oncotic cytology in the urine. After several years, she developed a new recurrence in the left renal pelvis and left ureter. Despite multiple tumors, as the patient had a single kidney, a therapy with lower morbidity was selected. This comprised endoscopic resection of the lesion and laser ablation at its base. After years of follow-up, the patient showed no evidence of disease recurrence and remained under follow-up. Lynch syndrome is a pathology with the potential for multisite tumors. It is extremely important for urologists to understand this syndrome because urothelial tumors of the upper urinary tract may be the initial manifestation of this syndrome. Screening must be individualized for each patient, considering the limitations of each method.
Substituting phenol in phenol-formaldehyde resins for wood modification by phenolic cleavage products from vacuum low-temperature microwave-assisted pyrolysis of softwood kraft lignin
Authors: Karthäuser Johannes , Biziks Vladimirs , Frauendorf Holm , Hoffmann Lisa , Raskop Salomé , Roggatz Daniel , Militz Holger
Published: February 2023

Wood modification using phenol-formaldehyde resins (PF resins) is a well-known and commercialized method to improve, amongst others, the dimensional stability and the durability of wood. However, phenol is mainly obtained from non-renewable resources, and the substitution of phenol by renewable resources has been a topic of research interest for years. Due to the high availability of technical lignins, lignin-derived cleavage products are promising candidates. In this study, organic cleavage products obtained from vacuum low-temperature microwave-assisted pyrolysis of softwood kraft lignin were used to substitute up to 45% of phenol in PF resins. The curing behavior and the free formaldehyde content of the resins was studied. Pine sapwood was treated with these resins by a vacuum pressure treatment, and the weight percent gain, leaching, and dimensional stability of the species were examined. Selected samples were analyzed with microscopy. The results indicate that up to 30% substitution of phenol by lignin-based organic products does not lead to significantly inferior wood modifications. At a substitution of 45%, the performance decreases, most likely due to the lower reactivity of the lignin cleavage products compared to pure phenol. The method described in this study could be a way to improve the environmental footprint of wood modification by PF resins.
A General Guide for Harmonizing Data: Drawing Lessons from Harmonizing COVID-19 PHSM Data
Authors: Cheng Cindy , Messerschmidt Luca , Bravo Issac , Waldbauer Marco , Bhavikatti Rohan , Schenk Caress , Grujic Vanja , Model Tim , Kubinec Robert , Barceló Joan
Published: February 2023

Data harmonization is an important method for generating the requisite datasets to support big data analyses. To date however, articles about data harmonization are field-specific and highly technical, making it difficult for researchers to derive general principles for how to engage in and contextualize data harmonization efforts. This article provides general guidance and criteria for researchers who are considering undertaking such efforts or seek to evaluate the quality of existing ones. We derive these guidelines from the extant literature and our own experience in harmonizing data for the emergent and important new field of COVID-19 public health and safety measures (PHSM). We further introduce the methodology we employed for engaging in this data harmonization as a blueprint for researchers interested in engaging in manual data harmonization.
Janus-faced fucose as a nutrient ligand for Dikarya and a building block of Early Diverging Lineages
Authors: Orłowska Małgorzata , Barua Drishtee , Piłsyk Sebastian , Muszewska Anna
Published: February 2023

Fucose is a deoxyhexose sugar present and studied in mammals. The process of fucosylation has been the primary focus in studies relating to fucose in animals due to the presence of fucose in Lewis antigens. Very few studies have reported its presence in Fungi, mostly in Mucoromycotina. The constitution of 25% and 12% of this sugar in the carbohydrates of cell wall in the respective Umbelopsis and Mucorales strains boosts the need to bridge the gap of knowledge on fucose metabolism across the fungal tree of life. In the absence of a network map involving fucose proteins, we carried out an in-silico approach to construct the fucose metabolic map in Fungi. We analyzed the taxonomic distribution of 85 protein families in Fungi including diverse early diverging fungal lineages. The expression of fucose-related protein-coding genes proteins was validated with the help of transcriptomic data originating from representatives of early diverging fungi. We found proteins involved in several metabolic activities apart from fucosylation such as synthesis, transport and binding. Most of the identified protein families are shared with Metazoa suggesting an ancestral origin in Opisthokonta. However, the overall complexity of fucose metabolism is greater in Metazoa than in Fungi. Massive gene loss has shaped the evolutionary history of these metabolic pathways leading to a repeated complete deletion in most yeast-forming lineages. Our results point to a distinctive mode of utilization of fucose among fungi belonging to Dikarya and the early diverging lineages. While Dikarya used fucose as a source of nutrients for metabolism, the early diverging group of fungi depended on fucose as a building block and signaling compound.
Indikatoren schulischer Transformationsprozesse unter den Bedingungen von Digitalität und Nachhaltigkeit
Authors: Pallesche Micha
Published: February 2023

Schulen stehen aktuell vor der zentralen Herausforderung, Kinder und Jugendliche auf eine Welt vorzubereiten, die von wachsender Komplexität und sich zuspitzenden Problemlagen wie dem Klimawandel und einer ungerechten Ressourcenverteilung gekennzeichnet ist. Korrekturen an den Oberflächenstrukturen zeigen in der Breite kaum Erfolg. Lediglich einzelnen Schulen gelingt es, grundlegende Transformationsprozesse hin zu einer nachhaltigeren und gerechteren Gesellschaft auch unter schwierigen Bedingungen anzustossen und umzusetzen. Veränderte kulturelle Praktiken der Kultur der Digitalität gewinnen an diesen Schulen zunehmend an Bedeutung. Im Rahmen des Beitrags werden Ergebnisse einer qualitativ angelegten Studie vorgestellt, in der mithilfe von Gruppendiskussionen unter Lehrenden an «Good-Practice-Schulen» relevante Indikatoren erfolgreicher schulischer Transformationsprozesse induktiv aus dem Material generiert wurden, die in die Beantwortung der Frage münden: Wie gelingt Schultransformation im Spannungsfeld von Digitalität und Nachhaltigkeit?
THEORETICAL AND METHODOLOGICAL BASIS FOR DETERMINING VECTORS OF THE DEVELOPMENT OF STRATEGIC MANAGEMENT OF BANKS AND THE FORMATION OF THEIR BUSINESS MODELS
Authors: Vasilyeva T. , Goncharenko T. , Mordan Ye.
Published: February 2023

In the work, the theoretical principles of determining trends and vectors of scientific research on issues of strategic management and the formation of the business model of banks are formed, which, unlike the existing ones, are based on the results of the structuring of the existing research work using the VOSviewer v toolkit. 1.6.10, Web of Science Results Analysis Tool, Scopus Citation Overview tool. The structuring of the scientific work on issues of strategic management and the business model of banks was carried out in the following sequence: 1) determination of the quantitative trend of articles; 2) identification the main subject areas; 3) determination of the most cited articles and journals; 4) clustering of articles in relation to the main directions of research in order to determine further analysis options.
A dynamic analysis of the number of scientific publications on the issues of strategic management and business models of banks proved that during 1991–2004, the focus of scientific attention was on issues related to business models of banks, in the period 2005–2010, the issues of the formation of business models of banks were studied simultaneously with issues of strategic management, and since 2015, the focus of scientific research has been on the topic of strategic management of banks. The results of the bibliometric analysis proved the presence 5 clusters summarizing the context of research on strategic management of banks, as well as 7 clusters - on issues of business models of banks. The identified trends proved that the triangle "profitability - risk - reliability" and information technologies and regulation are becoming an important part of the banking business model, while financial technologies, information management are an important part of the strategic management of banking activities. At the same time, the development of a business strategy, business model, balancing the profitability-risk-stability triangle in the trend of strategic management of banking activities is becoming more and more important for the bank due to the growing demands of customers and shareholders.
The conducted research made it possible to determine the phases of concentration of attention of scientists on the issues of strategic management and the business model of banks, to describe the vectors summarizing the meaningful context of research, as well as to substantiate the dominant tasks that arise during the formation and transformation of business strategies of banks at the current stage of the development of banking.
RISK OF LEGALIZATION OF FUNDS BY BANK CLIENTS FROM GAMBLING CONDUCTED ON THE INTERNET: APPROACHES TO MEASUREMENT
Authors: Kuzmenko O. , Boyko A. , Dotsenko T.
Published: February 2023

Today's fraudsters try to use modern financial services and products provided by banking institutions to legalize criminal proceeds and finance terrorism. Moreover, money laundering through banks using operations related to gambling occupies a significant place and has already turned into a serious financial problem. Currently, Internet gambling is a multi-billion dollar, extensive, widely used industry; specific economic activity, which includes illegal ways of exchanging virtual assets for real money, which causes an imbalance in economic processes. The most acute problems with money laundering arise in the direction of activity on the Internet, and especially through gambling, games and sports totalizers.
The purpose of this study is to identify money laundering schemes by bank clients through participation in game and sports totalizers, as well as to determine approaches to assessment, modeling aspects of the risk of legalization of funds from online gambling.
Theoretical research methods, such as: abstraction, synthesis, grouping, were used to conduct research and obtain results. and empirical methods, namely: observation and description.
In the course of the study, the existing schemes of money laundering through participation in Internet gaming and sports totalizers were highlighted. They point out that the existing regulatory measures regarding online gambling are mainly based on a passive policy of dealing with already received negative consequences. Global approaches to modeling, evaluation, and forecasting of certain aspects of gambling have been identified, which partially help in identifying and assessing the risk of laundering illegal funds: longitudinal modeling; a model for assessing the effectiveness of gaming companies in preventing fraud and money laundering, including on the Internet; a model of national and supranational risk assessment of the financial and non-financial sectors from the point of view of the threat of money laundering; a quantile regression model of in-game bets on a large online gambling data set to detect money laundering; a model for predicting the behavior of Internet players with the establishment of restrictions using machine learning algorithms using account data to identify the risk of legalization of illegal funds.
A clear understanding of the types, ways, schemes of threats that can contribute to the laundering of illegal funds, as a result, will provide a practical opportunity for financial institutions to form automatic notifications about suspicious financial transactions, predict and control potential risks, for more efficient organization of their functioning and conducting financial transactions. The results of the conducted research will help, among other things, the state regulatory bodies to make certain changes to the existing state policy of combating the laundering of criminal funds and the financing of terrorism.
The impact of COVID-19 and bank capital ratio on loan changes of ASEAN-5’s banking industry
Authors: Abraham Hukom Michael , Wibisono Lubis Arief
Published: February 2023

The COVID-19 pandemic has affected economies around the world, including the banking industry, and this depends on various factors. The aim of this study is to understand the influence of COVID-19 independently and through the moderation of bank capital ratios on changes in loans of Association of Southeast Asian Nations 5 (ASEAN-5) banking industry players. The study uses a sample of 86 banking companies listed on the stock markets of Indonesia, Malaysia, the Philippines, Singapore, and Thailand from the first quarter of 2018 to the fourth quarter of 2020 by employing the panel data regression technique. The results showed that COVID-19 had a significant negative effect on changes in bank lending. However, a bank’s capital ratio was not found to play a role in moderating the effect of COVID-19 on changes in bank lending. These findings have three main implications: (i) the role of the government in recapitalization and liquidity injection can eliminate differences in behavior between banks with the classification of capital ratios; (ii) there are no signs of zombie lending in ASEAN-5’s banking industry; and (iii) regulating incentives to change bank lending behavior in future crises must take into account that bank capital categorization will not be effective.
AcknowledgmentThis study was made possible with the support of a research grant by Universitas Indonesia number NKB-533/UN2.RST/HKP.05.00/2022.
Assessment of Ora-Pro-Nobis (Pereskia aculeata Miller) Leaves Shelf-Life in Different Conditions by Using NIR Spectroscopy and Augmented Matrices with Chemometrics
Authors: Furlan Fernanda , Matsushita Makoto , Coqueiro Aline , Março Paulo Henrique , Valderrama Patrícia
Published: February 2023

Ora-pro-nobis (Pereskia aculeata Mill) is an unconventional food plant (UFP) rich in proteins, vitamins, fibers, and antioxidants. In this study, ora-pro-nobis leaves were investigated as a proof‑of‑concept by near-infrared (NIR) spectroscopy concerning the storage time (from collection to 12 days), packaging system: styrofoam-based packaging covered with stretchable polychloride vinyl (PVC) film, and vacuum packaging (nylon/poly), temperature (at room temperature of 20 ºC, and in the refrigerator at 4 ºC), and sanitization condition (washed and without washing). Principal component analysis (PCA) was applied to augmented matrices, showing that unwashed leaves stored in the refrigerator with styrofoam-based packaging covered with PVC film were better preserved over time. Furthermore, it has been suggested that NIR absorptions are related to proteins, carbohydrates, lipids, vitamins, antioxidants, and water from ora-pro-nobis leaves and their physiological reactions over time. By combining NIR spectroscopy and chemometrics, a complete understanding of the shelf life of ora-pro-nobis leaves was achieved.
İki Farklı Metalik Kapı Yöntemiyle Oluşturulan Hall Bar’daki Sıkıştırılamaz Şeritlerin Kalınlıkları ve Elektron Hızı
Authors: EKŞİ Deniz
Published: February 2023

Bu çalışmada, üç boyutlu hetero yapılarda oluşturulan iki boyutlu elektron sistemi üzerinde metalik kapılar kullanılarak tanımlanabilen Hall bar geometrisi, iki farklı kapı yöntemi için incelenmiştir. Hesaplamalarda üç boyutlu Poisson denklemi, kendinden tutarlı çözülerek elektron yoğunluğunun ve potansiyel profilinin iki boyutlu uzaysal dağılımları belirlenmiştir. Dik bir manyetik alan varlığında, her iki kapı yöntemi ile elde edilen elektron dağılımlarında oluşan sıkıştırılamaz şeritlerin yerleri, kalınlıkları ve bu bölgelerdeki elektronların hızları manyetik alanın bir fonksiyonu olarak sunulmuştur. Manyetik alanın artması ile Sıkıştırılamaz Şeritlerin kalınlıklarının arttığı ve bu bölgelerdeki elektronların hızlarının azaldığı görülmektedir. Yapılan hesaplamaların sonuçları, daha önce yapılmış çalışmalar ile uyumludur. Aynı zamanda, çalışmanın, kuantum sensörler ve bilgisayarlar alanında katkı sunacağı düşünülmektedir.
EPS Daneciklerinin ve/veya Cam Tozunun Killi Zeminlerin Kıvam Limitlerine Etkisi ve Limitlerin YSA ve Regresyon ile Tahmin Edilmesi
Authors: AKIS Ebru , ÇİĞDEM Öykü Yağmur
Published: February 2023

Zeminlerin kıvam özellikleri, zeminlerin sınıflandırmasında ve parametrelerinin tahmin edilmesinde önemli bir araçtır. Bu çalışmanın ilk bölümünde atık malzeme ile iyileştirilen killi zeminin kıvam limitlerinde meydana gelen değişiklikler deneysel olarak incelenmiştir. Çalışmada birleştirilmiş zemin sınıflamasına göre yüksek plastisiteli kil olan bentonit kullanılmıştır. Bentonit, yalnız atık cam tozu, yalnız atık genleştirilmiş polistiren (EPS) daneleri ve her iki katkı malzemesinin farklı oranlarda kullanılmasıyla iyileştirilmiş ve likit limit ve plastik limit deneyleri yapılmıştır. Çalışmanın ikinci bölümünde ise bu çalışmada elde edilen sonuçlar ile literatürdeki benzer çalışmaların deney sonuçları kullanılarak cam tozu ve/veya EPS daneleriyle iyileştirilen zeminlerin kıvam limitleri için 65 veri derlenmiştir. Bu verilerin %80’i eğitim veri seti, %20’si doğrulama veri seti olarak kullanılmak üzere düzenlenmiştir. Çoklu lineer regresyon yöntemiyle ampirik bağıntılar, eğitim veri seti kullanılarak elde edilmiştir. Yine, aynı veri seti yapay sinir ağları yönteminde kullanılmış ve algoritma eğitilmiştir. Her iki yöntem, doğrulama veri seti ile çalıştırılmış ve sonuçlar karşılaştırılmıştır. Her iki yöntemde de eğitim ve doğrulama veri setlerinden elde edilen determinasyon katsayıları oldukça yüksek olup iyileştirilmiş killerin kıvam limitlerinin gerçeğe yakın tahmin edileceği düşünülmektedir. Ayrıca, yapay sinir ağları yöntemi ile elde edilen sonuçların seçilen veri setlerinden bağımsız olduğunu kontrol etmek amacıyla, öğrenme yöntemlerinde genellikle uygulanan bir yaklaşım olan çapraz geçerlilik testi yapılarak çalışmada kullanılan algoritmanın geçerliliği test edilmiştir. Bu çalışma sonucunda, atık cam tozu ve/veya atık EPS daneleriyle iyileştirilen killi zeminlerin kıvam limitlerinin tahmin edilmesinde kullanılmak üzere ampirik bağıntılar ve yapay sinir ağları yöntemi önerilmektedir
Detection of Monkeypox Among Different Pox Diseases with Different Pre-Trained Deep Learning Models
Authors: ÇELİK Muhammed , İNİK Özkan
Published: February 2023

Monkeypox is a viral disease that has recently rapidly spread. Experts have trouble diagnosing the disease because it is similar to other smallpox diseases. For this reason, researchers are working on artificial intelligence-based computer vision systems for the diagnosis of monkeypox to make it easier for experts, but a professional dataset has not yet been created. Instead, studies have been carried out on datasets obtained by collecting informal images from the Internet. The accuracy of state-of-the-art deep learning models on these datasets is unknown. Therefore, in this study, monkeypox disease was detected in cowpox, smallpox, and chickenpox diseases using the pre-trained deep learning models VGG-19, VGG-16, MobileNet V2, GoogLeNet, and EfficientNet-B0. In experimental studies on the original and augmented datasets, MobileNet V2 achieved the highest classification accuracy of 99.25% on the augmented dataset. In contrast, the VGG-19 model achieved the highest classification accuracy with 78.82% of the original data. Considering these results, the shallow model yielded better results for the datasets with fewer images. When the amount of data increased, the success of deep networks was better because the weights of the deep models were updated at the desired level.
YOLO V7 and Computer Vision-Based Mask-Wearing Warning System for Congested Public Areas
Authors: EĞİ Yunus
Published: February 2023

The impact of Covid 19 cases is increasing worldwide due to not complying with social distancing and mask-wearing rules in congested areas such as hospitals, schools, and malls where people have to be together. Although the authorities have taken various precautions to prevent not wearing masks, it is challenging to inspect masks in crowded areas. People who do not wear masks can be unnoticed by visual inspections, which is a critical factor in the increase of the epidemic. This study aims to create an Artificial Intelligence (AI) based mask inspection system with the YOLO V7 deep learning method to ensure that overcrowded public areas are protected from the Covid-19 epidemic.
The role of the class teacher as a teacher-mentor in the formation of new values and social relations among adolescents in the prevention of Internet addiction
Authors: Sereda Irina Nikolaevna
Published: February 2023

In today's world, the Internet is developing dynamically. On its basis, a special socio-cultural environment is created with its own specific content as a special social space. In this regard, the role and importance of the class teacher as a teacher-mentor, his active participation in the formation of new values and social relations in adolescents in organized activities, including in the prevention of Internet addiction, is increasing
„Pedagogika lasu” jako (nie)nowa orientacja w pedagogice
Authors: Śliwerski Bogusław
Published: February 2023

Autor dokonuje analizy genezy i ewolucji pedagogiki naturalistycznej, zorientowanej na edukację w naturze, w tym szczególnie w lesie, w czasach od Jana Jakuba Rousseau aż po obecne czasy, w krajach Europy i w USA. Wskazuje na dwie formy organizacji procesu kształcenia i wychowania w lesie, pisze o lesie i dla lasu, a mianowicie reprezentuje podejście instytucjonalne w postaci tworzenia przedszkoli i szkół leśnych oraz edukację pozaszkolną, środowiskową, z której każda grupa wiekowa może korzystać w swoim czasie wolnym. W podsumowaniu formułuje tezę o włączeniu badań naukowych i praktyk edukacyjnych w lesie do nauk humanistyczno-społecznych bez potrzeby wyłaniania odrębnej dyscypliny naukowej.
Zaangażowanie i gotowość nauczycieli wychowania przedszkolnego pracujących na Mazowszu w proces realizacji treści związanych z szeroko rozumianą ekologią
Authors: Mikler-Chwastek Anna
Published: February 2023

W artykule zaprezentowano wyniki badań prowadzonych w 2022 roku z udziałem nauczycieli wychowania przedszkolnego z województwa mazowieckiego. Ich celem było ustalenie, w jaki sposób nauczyciele wychowania przedszkolnego pracujący na co dzień z dziećmi angażują się w proces realizacji treści związanych z szeroko rozumianą ekologią. Realizując cel, postawiłam następujące pytania badawcze:

czy nauczyciele wychowania przedszkolnego realizują treść ekologiczne w grupie przedszkolnej;

jak często prezentują te treści;

jaki rodzaj treści ekologicznych nauczyciele prezentują swoim podopiecznym;

czy nauczyciel czuje się odpowiednio przygotowany do prowadzenia zajęć w przedszkolu z tematyki dotyczącej ekologii i zrównoważonego rozwoju.

W artykule poza wynikami badań zawarto przegląd literatury, procedurę badawczą oraz wnioski.
Nie ma edukacji bez relacji
Authors: Marszałek Lidia
Published: February 2023

Prezentowany tekst zawiera krytykę funkcjonowania współczesnej polskiej szkoły. Ukazuje jej niedomagania i braki w kontekście przygotowania uczniów do realnego życia. Wskazuje też na wagę relacji nauczyciel–uczeń w kształtowaniu osobowości ucznia (ale też nauczyciela) dla pełnego rozwoju osobowego ich obu. Relacja osobowa jest bowiem, zdaniem autorki, podstawą skutecznej edukacji i zainteresowania ucznia nauką szkolną.
Fathers’ imprisonment as perceived by their children
Authors: Domżalska Aneta
Published: February 2023

The author presents the results of a study on selected aspects of fathers’ imprisonment from the perspective of their children. The study included 72 children, aged 12 to 18 years, whose fathers were imprisoned in penal institutions in Poland. The analysis of results revealed that all of the children knew that their fathers were serving a prison sentence. Most children report unpleasant emotions related to this fact, such as regret, sadness, anger, and shame. On the other hand, the vast majority of the children understood that their parent had made a mistake and that they were bearing the consequences of their act. The vast majority of respondents maintained contact with their fathers (e.g., visitations, telephone calls, letters), but the frequency of these contacts was quite low. The children claimed that during contact with their fathers they experienced various emotions: from nervousness, sadness, and shame at where their parent was, to satisfaction with and joy at the possibility of meeting the father. The vast majority of prisoners’ children reported that the frequency and quality of their contact with the father was inadequate and suggested changes. Taking account of prisoners’ children’s perspective, the study encourages further local research addressing this issue.
Działania promocyjno-edukacyjne z udziałem asystentów zdrowienia w środowiskowym modelu opieki psychiatrycznej
Authors: Bartosiewicz-Niziołek Monika , Olszewski Bartosz H. , Ostrowska Magda
Published: February 2023

Działania promocyjno-edukacyjne, do których można zaliczyć promocję zdrowia oraz edukację zdrowotną, stanowią integralną część działań podejmowanych przez podmioty środowiskowego modelu opieki psychiatrycznej. Promocja zdrowia jest procesem polegającym na umożliwianiu ludziom zwiększania wpływu na własne zdrowie i jego poprawę, zaś edukacja zdrowotna pozwala na przekazanie wiedzy, jak dbać o zdrowie. Dodatkowo, promocja zdrowia jest często łączona z działaniami o charakterze prewencji psychologicznej. W artykule zwrócono szczególną uwagę na promocję zdrowia psychicznego. Ponadto nakreślono rolę i zadania asystentów zdrowienia w środowiskowym modelu opieki psychiatrycznej oraz ich udział w środowiskowych działaniach profilaktyczno-promocyjnych. Wskazano również na efekty i perspektywy dla rozwoju działań promocyjno-edukacyjnych.
Manganese-independent Reverse Transcriptase Activity of Tth DNA
Polymerase with Two Amino Acid Substitutions
Authors: Luo Zhidan , Xue Yong , Chen Xiaoyu , Zhang Jian , Lu Chen
Published: February 2023

Background:

The DNA polymerase of Thermus thermophilus (Tth pol) presents reverse
transcriptase activity with Mn2+, and can be used for one-step RT-qPCR. However, Mn2+ would reduce
amplification fidelity and cause nonspecific products.

Objective:

Eliminating the Mn2+ dependence of the reverse transcriptase activity of Tth pol by point
mutations.

Methods:

We constructed three variants I640F, I709K, and I640F/I709K, and measured their DNA
polymerase and reverse transcriptase activities without Mn2+. Their enzymatic characteristics and PCR
inhibitor resistance were also tested. Finally, these variants were applied in one-step RT-qPCR.

Results:

All three variants presented reverse transcriptase activity with Mg2+ only and increased DNA
polymerase activity. The variants, except I709K, showed no significant difference in thermostability,
optimal pH, optimal NaCl concentration, storage stability and PCR inhibitor resistance compared to the
wild type. Variant I640F/I709K had good performance in one-step RT-qPCR with Mg2+ only, whereas
both variants with single substitution exhibited nonspecific amplification.

Conclusion:

We successfully constructed three Tth pol variants possessing Mn2+ independent reverse
transcriptase activity. The variant I640F/I709K was suitable for one-step RT-qPCR because of its good
performance.
Network Pharmacology and Integrated Molecular Docking Study on the Mechanism
of the Therapeutic Effect of Fangfeng Decoction in Osteoarthritis
Authors: Jiang Zehui , Wang Wenqiao , Li Min , Si Hongzong
Published: February 2023

Background:

At present, there are no effective pharmacologic therapies for attenuating the course of osteoarthritis (OA) in humans and current therapies are geared to mitigating symptoms. Fangfeng decoction (FFD) is a traditional Chinese medicine prescribed for the treatment of OA. In the past, FFD has achieved positive clinical outcomes in alleviating the symptoms of OA in China. However, its mechanism of action has not yet been clarified.

Objective:

The objective of this study is to investigate and explore the mechanism of FFD and how the compound interacts with the target of OA; network pharmacology and molecular docking methods were applied in this study.

Methods:

The active components of FFD were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) database according to the inclusion criteria as oral bioactivity (OB) ≥30% and drug likeness (DL) ≥0.18. Then, gene name conversion was performed through the UniProt website. The related target genes of OA were obtained from the Genecards database. Core components, targets, and signaling pathways were obtained through compound-target-pathway (C-T-P) and protein–protein interaction (PPI) networks were built using Cytoscape 3.8.2 software. Matescape database was utilized to get gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of gene targets. The interactions of key targets and components were analyzed by molecular docking in Sybyl 2.1 software.

Results:

A total of 166 potential effective components,148 FFD-related targets, and 3786 OA-related targets were obtained. Finally, 89 common potential target genes were confirmed. Pathway enrichment results showed that HIF-1 and CAMP signaling pathways were considered key pathways. The screening of core components and targets was achieved through the CTP network. The core targets and active components were obtained according to the CTP network. The molecular docking results showed that quercetin, medicarpin, and wogonin of FFD could bind to NOS2, PTGS2, and AR, respectively.

Conclusion:

FFD is effective in the treatment of OA. It may be caused by the effective binding of the relevant active components of FFD to the targets of OA.
WITHDRAWN: Conjugation of Ruthenium Drugs to Nanocellulose using
Boronic Ester
Authors: Lu Mingxia , Khine Yee Yee , Shen Yuying , Stenzel Martina H.
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Cardiac Computed Tomography to Guide the Selection of Better Display
Angle of Cardiac Right Ventricular Pacing Electrode in Radiography
Authors: Wang Zhan Hong , Miao HongGuang , Wang Wei Qin , Kang SiYao , Jin HaiYing , Liu Dong Ting , Zhang Jun Meng
Published: February 2023

Background:

Traditional radiography angles do not adequately reveal the shape and position
of the right ventricular pacing electrode.

Objective:

This study aimed to explore better radiography angles with the help of cardiac computed
tomography (CT).

Methods:

We analyzed the cardiac CT images of consecutive outpatients from 2018 to 2019. The right
anterior oblique (RAO) 30° and the left anterior oblique (LAO) 40° were found to sufficiently display
the shape and position of the right ventricular pacing electrode.

Results:

A total of 214 consecutive outpatients were enrolled, whose average age was 55.0 ± 13.0
years, and 151 were male (70.6%). Through analyzing the cardiac CT images, the α angle (33.7° ± 6.1)
and the γ angle (38.8° ± 8.0) were determined. Furthermore, we verified these angles in 48 patients
after pacemaker implantation. The results showed that the ratio of the length of right ventricular electrode
using the RAO α angle (≈30°) to the posterior-anterior position (PA position) was 1.099 ± 0.157
VS 1.053 ± 0.182 (the ratio using the traditional RAO 45°) (P < 0.001). We observed that the relationship
between the right ventricular active electrode and the ventricular septum was better identified
using the LAO γ angle (≈40°) than the traditional 60° angle.

Conclusion:

With the help of cardiac CT, we found that RAO 30° could better show the shape and
length of the right ventricular pacing electrode, and LAO 40° could better show the positional relationship
between the pacing electrode and the ventricular septum.
The Role of Theragnostics in Breast Cancer: A Systematic Review of the
Last 12 Years
Authors: Balma Michele , Liberini Virginia , Buschiazzo Ambra , Racca Manuela , Rizzo Alessio , Nicolotti Daniele Giovanni , Laudicella Riccardo , Quartuccio Natale , Longo Michelangelo , Perlo Giorgia , Terreno Enzo , Abgral Ronan , William Huellner Martin , Papaleo Alberto , Deandreis Désirée
Published: February 2023

Background:

Breast cancer is the most common malignancy in women, with high morbidity and mortality. Molecular alterations in breast cancer involve the expression or upregulation of various molecular targets that can be used for diagnostic nuclear medicine imaging and radiopharmaceutical treatment. Theragnostics is based on the binding of radionuclides to molecular targets. These radionuclides can induce a cytotoxic effect on the specific tumor cell (target) or its vicinity, thus allowing a personalized approach to patients with effective treatment and comparably small side effects.

Aim:

This review aims to describe the most promising molecular targets currently under investigation for theragnostics and precision oncology in breast cancer.

Methods:

A comprehensive literature search of studies on theragnostics in breast cancer was performed in the PubMed, PMC, Scopus, Google Scholar, Embase, Web of Science, and Cochrane library databases, between 2010 and 2022, using the following terms: breast neoplasm*, breast, breast cancer*, theragnostic*, theranostic*, radioligand therap*, RLT, MET, FLT, FMISO, FES, estradiol, trastuzumab, PD-L1, PSMA, FAPI, FACBC, fluciclovine, FAZA, GRPR, DOTATOC, DOTATATE, CXC4, endoglin, gastrin, mucin1, and syndecan1.

Results:

Fifty-three studies were included in the systematic review and summarized in six clinical sections: 1) human epidermal growth factor receptor 2 (HER2); 2) somatostatin receptors (SSTRS); 3) prostate-specific membrane antigen radiotracers (PSMA); 4) fibroblast activation protein-α targeted radiotracers; 5) gastrin-releasing peptide receptor-targeted radiotracers; 6) other radiotracers for theragnostics.

Conclusion:

The theragnostic approach will progressively allow better patient selection, and improve the prediction of response and toxicity, avoiding unnecessary and costly treatment.
A Novel Nanocomposite Scaffold Based on Polyurethane (PU) Containing
Cobalt Nanoparticles (CoNPs) for Bone Tissue Engineering Applications
Authors: Norouz Faezeh , Poormoghadam Delaram , Halabian Raheleh , Ghiasi Mohsen , Monfaredi Monireh , Salimi Ali
Published: February 2023

Background:

Bone tissue engineering, as a relatively new approach, has focused on combining
biodegradable scaffolds, cells, and biologically active molecules for the recovery of different damaged
tissues, such as bone defects. Polyurethane (PU), as a synthetic polymer, benefits from a porous structure
which impersonates bone's natural environment. However, PU lacks osteoinduction activities. Cobalt
nanoparticles (CoNPs) stimulate angiogenesis and biomineralization, which greatly favors osteogenesis.

Methods:

Here, we designed a novel scaffold based on PU and combined it with CoNPs for bone regeneration
applications. The composition and structure of PU-CoNPs nanocomposite were characterized
using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and differential
scanning calorimetry (DSC). MTT and AO data showed biocompatibility and enhanced viability
and proliferation of fibroblasts on PU-CoNPs scaffold. Ascorbic acid-2-phosphate, β-glycerophosphate,
and dexamethasone-induced osteogenesis for 14 days.

Results:

The alkaline phosphatase test asserts the increased mineralization of hADSCs cultured on PUCoNPs
compared to pure PU scaffold. Further, the results disclosed an elevated osteogenic differentiation
at the level of genes and proteins using immunocytochemical analysis (ICC) and quantitative real-time
PCR (qPCR).

Conclusion:

These findings provide an evidence that PU-CoNPs nanocomposite might be a promising
candidate for bone repair applications.
Facial Emotion Recognition using Wavelet Analysis and Histogram of
Oriented Gradients of Image
Authors: Mohanta Soumya Ranjan , Veer Karan
Published: February 2023

Background:

A number of disciplines, including security, healthcare, and human-machine
interactions, have presented and used techniques for emotion recognition based on facial expressions.

Objective:

To increase computer prediction, researchers are advancing the methods for deciphering
code and extracting facial emotions.

Methods:

The contamination of the image with noise, which alters the features of the images and ultimately
impacts the accuracy of the system, is one of the major issues in this sector. Thus, noise
should be eliminated or diminished. The wavelet transform approach is used in this study to denoise
the images before categorization. The classification accuracies for original images are also obtained to
analyze the effect of denoising on the classification accuracy of the facial expression images.

Results and Conclusion:

Three machine learning approaches, support vector machine, k-nearest
neighbor, and naive bayes, are utilized to classify the emotions in this instance. The feature employed
is the histogram of directional gradients of images. The classification results are obtained and the effect
of denoising on the classification accuracy of the facial expression images is analyzed. Also, our
best-obtained result for the wavelet transform method is compared with other wavelet transform-based
facial emotion recognition techniques. And our result is found to be promising.
Optimization Design and Experimental Study of Cooling System in a High
Voltage Induction Motor after Power Density Upgrade
Authors: Lü Qingqing , Wang Xiaojun , Yang Liquan , Tian Gaowei , Li Guangxi
Published: February 2023

Background:

In order to upgrade a motor based on the YXKK450-2 for high power
density with high efficiency, low energy consumption, and low weight with the same volume,
its power is increased from the original 900 kW to 1250 kW. To ensure good ventilation and
heat dissipation characteristics, it is necessary to redesign the ventilation and cooling system of
the entire machine.

Methods:

Based on the finite volume method, a physical model of the entire flow field of the
motor's inner and outer air passages was established. The internal and external cooling systems
of the motor were simulated, and the fluid flow law of the cooling system was realized. By extracting
the pressure difference between the inlet and outlet of the cooler and the circulating
cooling air velocity in the inner air passage, the boundary conditions for calculating the flowheat
coupling field were determined. The temperature rise trend and overall temperature distribution
were obtained.

Results:

The results of the test resistance method were in good agreement with the numerical
simulation test results, The temperature rise error was 4%, and the wind speed value error was
2.7%, all within allowable limits (<s5%), verifying the accuracy and effectiveness of the calculation
method.

Conclusion:

An accurate prediction of motor temperature rise, fluid flow law, and temperature
distribution is achieved.
Withdrawal Notice: Design and Analysis of an Anti-Interference Measurement Method for Transmission Line Impedance Parameters
Authors: Bao Wenjun , Sun Qiang , Wang Yongsheng , Bao Shijie
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has
been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Proceedings of the 2021 Mathematics in Industry Study Group
Authors: Thamwattana Natalie , Meylan Michael H. , Roberts Anthony John
Published: February 2023

This special Section of the ANZIAM Journal (Electronic Supplement) contains the refereed papers from the 2021 Mathematics in Industry Study Group (MISG-2021) held at the University of Newcastle from 27 to 30 January 2021. This report provides the equation-free outcomes.
Evaluation of a Mobile-Based Immunization Decision Support System for Scheduling Age-Appropriate Vaccine Schedules for Children Younger Than 2 Years in Pakistan and Bangladesh: Lessons From a Multisite, Mixed Methods Study
Authors: Siddiqi Danya Arif , Ali Rozina Feroz , Shah Mubarak Taighoon , Dharma Vijay Kumar , Khan Anokhi Ali , Roy Tapash , Chandir Subhash
Published: February 2023

Background

Missed opportunities for vaccination (MOVs), that is, when children interact with the health system but fail to receive age-eligible vaccines, pose a crucial challenge for equitable and universal immunization coverage. Inaccurate interpretations of complex catch-up schedules by health workers contribute to MOVs.

Objective

We assessed the feasibility of a mobile-based immunization decision support system (iDSS) to automatically construct age-appropriate vaccination schedules for children and to prevent MOVs.

Methods

A sequential exploratory mixed methods study was conducted at 6 immunization centers in Pakistan and Bangladesh. An android-based iDSS that is packaged in the form of an application programming interface constructed age-appropriate immunization schedules for eligible children. The diagnostic accuracy of the iDSS was measured by comparing the schedules constructed by the iDSS with the gold standard of evaluation (World Health Organization–recommended Expanded Programme on Immunization schedule constructed by a vaccines expert). Preliminary estimates were collected on the number of MOVs among visiting children (caused by inaccurate vaccination scheduling by vaccinators) that could be reduced through iDSS by comparing the manual schedules constructed by vaccinators with the gold standard. Finally, the vaccinators’ understanding, perceived usability, and acceptability of the iDSS were determined through interviews with key informants.

Results

From July 5, 2019, to April 11, 2020, a total of 6241 immunization visits were recorded from 4613 eligible children. Data were collected for 17,961 immunization doses for all antigens. The iDSS correctly scheduled 99.8% (17,932/17,961) of all age-appropriate immunization doses compared with the gold standard. In comparison, vaccinators correctly scheduled 96.8% (17,378/17,961) of all immunization doses. A total of 3.2% (583/17,961) of all due doses (across antigens) were missed in age-eligible children by the vaccinators across both countries. Vaccinators reported positively on the usefulness of iDSS, as well as the understanding and benefits of the technology.

Conclusions

This study demonstrated the feasibility of a mobile-based iDSS to accurately construct age-appropriate vaccination schedules for children aged 0 to 23 months across multicountry and low- and middle-income country settings, and underscores its potential to increase immunization coverage and timeliness by eliminating MOVs.