bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Performance and Power Optimization with Heterogeneous Processing-in-Memory for AI Applications on Edge Devices
Authors: Jeon Sangmin , Lee Kangju , Lee Kyeongwon , Lee Woojoo
Published: September 2024

The rapid advancement of artificial intelligence (AI) technology, combined with the widespread proliferation of Internet of Things (IoT) devices, has significantly expanded the scope of AI applications, from data centers to edge devices. Running AI applications on edge devices requires a careful balance between data processing performance and energy efficiency. This challenge becomes even more critical when the computational load of applications dynamically changes over time, making it difficult to maintain optimal performance and energy efficiency simultaneously. To address these challenges, we propose a novel processing-in-memory (PIM) technology that dynamically optimizes performance and power consumption in response to real-time workload variations in AI applications. Our proposed solution consists of a new PIM architecture and an operational algorithm designed to maximize its effectiveness. The PIM architecture follows a well-established structure known for effectively handling data-centric tasks in AI applications. However, unlike conventional designs, it features a heterogeneous configuration of high-performance PIM (HP-PIM) modules and low-power PIM (LP-PIM) modules. This enables the system to dynamically adjust data processing based on varying computational load, optimizing energy efficiency according to the application’s workload demands. In addition, we present a data placement optimization algorithm to fully leverage the potential of the heterogeneous PIM architecture. This algorithm predicts changes in application workloads and optimally allocates data to the HP-PIM and LP-PIM modules, improving energy efficiency. To validate and evaluate the proposed technology, we implemented the PIM architecture and developed an embedded processor that integrates this architecture. We performed FPGA prototyping of the processor, and functional verification was successfully completed. Experimental results from running applications with varying workload demands on the prototype PIM processor demonstrate that the proposed technology achieves up to 29.54% energy savings.
Editorial for the Special Issue on AC Electrokinetics in Microfluidic Devices, Volume II
Authors: Ramos Antonio , García-Sánchez Pablo , Fernández-Mateo Raúl
Published: September 2024

The use of AC electric fields in manipulating and characterizing liquids and suspended particles in microfluidic systems continues to drive innovation in several fields, such as colloidal science, microelectronics, and biotechnology [...]
Improving TFT Device Performance by Changing the Thickness of the LZTO/ZTO Dual Active Layer
Authors: Guo Liang , Wang Suhao , Chu Xuefeng , Wang Chao , Chi Yaodan , Yang Xiaotian
Published: September 2024

The primary objective of this research paper is to explore strategies for enhancing the electrical performance of dual active layer thin film transistors (TFTs) utilizing LZTO/ZTO as the bilayer architecture. By systematically adjusting the thickness of the active layers, we achieved significant improvements in the performance of the LZTO/ZTO TFTs. An XPS analysis was performed to elucidate the impact of the varying O2 element distribution ratio within the LZTO/ZTO bilayer thin film on the TFTs performance, which was directly influenced by the modification in the active layer thickness. Furthermore, we utilized atomic force microscopy to analyze the effect of altering the active layer thickness on the surface roughness of the LZTO/ZTO bilayer film and the impact of this roughness on the TFTs electrical performance. Through the optimization of the ZTO active layer thickness, the LZTO/ZTO TFT exhibited an mobility of 10.26 cm2 V−1 s−1 and a switching current ratio of 5.7 × 107, thus highlighting the effectiveness of our approach in enhancing the electrical characteristics of the TFT device.
Antimicrobial and Antioxidant Activities of 18β-Glycyrrhetinic Acid Biotransformed by Aspergillus niger
Authors: El-Far Shaymaa Wagdy , Al-Saman Mahmoud A. , Abou-Elazm Fatma I. , Ibrahim Shebl Rania , Abdella Asmaa
Published: September 2024

The search for novel plant-based antioxidant and antibacterial medication has garnered a lot of attention lately. Glycyrrhiza glabra, known as licorice, is one of the most important medicinal plants. The primary component of Glycyrrhiza glabra is glycyrrhizin, which is biotransformed into 18α- and 18β-glycyrrhetinic acid for a variety of medicinal purposes. The goal of this study was to improve the bioavailability of glycyrrhizin by its biotransformation into glycyrrhetinic acid by Aspergillus niger. The biotransformation process was optimized using response surface methodology. A two-level Plackett–Burman design was employed to identify the factors that had a significant impact on the process of biotransformation. The three main variables were pH, glycerrhizin concentration, and incubation time. These three medium components were further optimized using a 3-level Box–Behnken design, and their optimum levels were pH of 8, an incubation period of 6 days, and a glycyrrhizin concentration of 1%. Using these optimum conditions, the maximum level obtained was 159% greater than in the screening experiment. Regarding the antimicrobial activity of glycyrrhizin extract, Bacillus subtilis emerged as the most sensitive organism with the lowest MIC (60 µg/mL) and the highest zone of inhibition (17 mm). The most resistant organism was Pseudomonas aeruginosa, which had the highest MIC (400 µg/mL) and the smallest zone of inhibition (10 mm). In the case of glycyrrhetinic acid, Bacillus subtilis was the most sensitive organism with the highest zone of inhibition (32 mm) and the lowest MIC (20 µg/mL). Pseudomonas aeruginosa was the most resistant organism, with the lowest zone of inhibition (18 mm), and the highest MIC (140 µg/mL). The antioxidant activity of glycyrrhizin extract increased from 12.81% at a concentration of 63 µg/100 µL to 41.41% at a concentration of 1000 µg/100 µL, while that of glycyrrhetinic acid extract increased from 35.5% at a concentration of 63 µg/100 µL to 76.85% at a concentration of 1000 µg/100 µL. The present study concluded that biotransformation of glycyrrhizin into glycyrrhetinic acid increased its bioavailability and antioxidant and antimicrobial activities. Glycyrrhizin and glycyrrhetinic acid might be used as a natural antimicrobial and antioxidant in pharmaceutical industries
Exploring the Spatial Variation in the Microbiota and Bile Acid Metabolism of the Compound Stomach in Intensively Farmed Yaks
Authors: He Shichun , Yuan Zaimei , Dai Sifan , Wang Zibei , Zhao Shusheng , Zhang Bin , Mao Huaming , Wu Dongwang
Published: September 2024

Yaks are one of the important livestock on the Qinghai–Tibet Plateau, providing abundant dairy and meat products for the local people. The formation of these dairy and meat products mainly relies on the microbiota in their gastrointestinal tract, which digests and metabolizes plant feed. The yak’s gastrointestinal microbiota is closely related to the health and production performance of the host, but the molecular mechanisms of diet-induced effects in intensively farmed yaks remain to be elucidated. In this study, 40 chyme samples were collected from the four stomach chambers of 10 intensively farmed yaks, and the bacterial diversity and bile acid changes in the rumen (SFRM), reticulum (SFRC), omasum (SFOM), and abomasum (SFAM) were systematically analyzed using 16S rRNA sequencing and bile acid metabolism. Our results showed that the gastrointestinal microbiota mainly distributes in the four-chambered stomach, with the highest microbial diversity in the reticulum. There is a highly negative correlation among the microbiota in the four chambers. The dominant bacterial phyla, Bacteroidota and Firmicutes, were identified, with Rikenellaceae_RC9_gut_group being the dominant genus, which potentially helps maintain short-chain fatty acid levels in the stomach. In contrast, the microbiome within the four stomach chambers synergistically and selectively altered the content and diversity of bile acid metabolites in response to intensive feeding. The results of this study provide new insights into the microbiota and bile acid metabolism functions in the rumen, reticulum, omasum, and abomasum of yaks. This can help uncover the role of gastrointestinal microbiota in yak growth and metabolic regulation, while also providing references for improving the production efficiency and health of ruminants.
Assessing Listeria monocytogenes Growth in Artificially Inoculated Sea-Farmed Product—Raw Sea Bass (Dicentrarchus labrax) Fillet, Produced in Greece
Authors: Vasileiadi Ntina , Tsironi Theofania , Mandilara Georgia D.
Published: September 2024

Listeria monocytogenes (Lm) is responsible for listeriosis, a serious foodborne disease, with high hospitalization and mortality rates worldwide. The main cause of listeriosis in humans is the consumption of ready-to-eat (RTE) foods; Commission Regulation (EC) No 2073/2005 establishes microbiological criteria for Lm in RTE foods. Raw fish products are widely consumed, e.g., in sushi and various seafood recipes (e.g., carpaccio, sashimi, maki, nigiri, tartare, etc.), but are not subjected to RTE food safety criteria. The aim of our study was to assess the growth potential of Lm in raw sea bass fillets obtained from a leading aquaculture company in Greece. In order to assess the growth of Lm in raw sea bass fillets, we applied the “challenge test”, a scientific experiment designed to assess the growth of Lm within a specific food product under controlled conditions. According to our results, and taking into consideration the health risk for the listeriosis-vulnerable population, raw fish products utilized in the preparation of RTE foods, including sushi and an array of seafood dishes, should be incorporated in the Category of Safety Criteria of Regulation (EC) No 2073/2005 “Ready-to-eat food able to support the growth of Listeria monocytogenes”.
Opportunities for Helicobacter pylori Eradication beyond Conventional Antibiotics
Authors: Savitri Camilia Metadea Aji , Fauzia Kartika Afrida , Alfaray Ricky Indra , Aftab Hafeza , Syam Ari Fahrial , Lubis Masrul , Yamaoka Yoshio , Miftahussurur Muhammad
Published: September 2024

Helicobacter pylori (H. pylori) is a bacterium known to be associated with a significant risk of gastric cancer in addition to chronic gastritis, peptic ulcer, and MALT lymphoma. Although only a small percentage of patients infected with H. pylori develop gastric cancer, Gastric cancer causes more than 750,000 deaths worldwide, with 90% of cases being caused by H. pylori. The eradication of this bacterium rests on multiple drug regimens as guided by various consensus. However, the efficacy of empirical therapy is decreasing due to antimicrobial resistance. In addition, biofilm formation complicates eradication. As the search for new antibiotics lags behind the bacterium’s ability to mutate, studies have been directed toward finding new anti-H. pylori agents while also optimizing current drug functions. Targeting biofilm, repurposing outer membrane vesicles that were initially a virulence factor of the bacteria, phage therapy, probiotics, and the construction of nanoparticles might be able to complement or even be alternatives for H. pylori treatment. This review aims to present reports on various compounds, either new or combined with current antibiotics, and their pathways to counteract H. pylori resistance.
A Longitudinal Study of Escherichia coli Clinical Isolates from the Tracheal Aspirates of a Paediatric Patient—Strain Type Similar to Pandemic ST131
Authors: Filipic Brankica , Kojic Milan , Vasiljevic Zorica , Sovtic Aleksandar , Dimkic Ivica , Wood Emily , Esposito Alfonso
Published: September 2024

Escherichia coli is a Gram-negative bacterium and part of the intestinal microbiota. However, it can cause various diarrhoeal illnesses, i.e., traveller’s diarrhoea, dysentery, and extraintestinal infections when the bacteria are translocated from the intestine to other organs, such as urinary tract infections, abdominal and pelvic infections, pneumonia, bacteraemia, and meningitis. It is also an important pathogen in intensive care units where cross-infection may cause intrahospital spread with serious consequences. Within this study, four E. coli isolates from the tracheal aspirates of a tracheotomised paediatric patient on chronic respiratory support were analysed and compared for antibiotic resistance and virulence potential. Genomes of all four isolates (5381a, 5381b, 5681, 5848) were sequenced using Oxford Nanopore Technology. According to PFGE analysis, the clones of isolates 5681 and 5848 were highly similar, and differ from 5381a and 5381b which were isolated first chronologically. All four E. coli isolates belonged to an unknown sequence type, related to the E. coli ST131, a pandemic clone that is evolving rapidly with increasing levels of antimicrobial resistance. All four E. coli isolates in this study exhibited a multidrug-resistant phenotype as, according to MIC data, they were resistant to ceftriaxone, ciprofloxacin, doxycycline, minocycline, and tetracycline. In addition, principal component analyses revealed that isolates 5681 and 5848, which were recovered later than 5381a and 5381b (two weeks and three weeks, respectively) possessed more complex antibiotic resistance genes and virulence profiles, which is concerning considering the short time period during which the strains were isolated.
Petrography of Ophiolitic Detritus from a Miocene Conglomerate Formation on Darnó Hill, SW Bükk Mts (N Hungary): A Unique Tool to Trace Covered Ophiolitic Sequences
Authors: Józsa Sándor
Published: September 2024

Petrographic studies have been carried out on the Early Miocene Darnó Conglomerate Formation, which consists only of debris of ophiolitic mélange and is found today on Darnó Hill in SW Bükk, NE Hungary. The studied sediments are bounded by the Darnó line from Darnó Hill. The aim of this work was to show if it is possible to reconstruct the petrographic composition of the source area only from its debris. The rock types were determined in thin sections using a polarizing microscope, and a quantitative analysis of the different rock types was carried out using the grain counting method, the results of which were interpreted as volume ratios. The main rock types observed in the studied samples (textural varieties of basalt, dolerite/microgabbro, claystone, siltstone, and radiolarite) are similar to the rock types of the mélange assemblage of Darnó Hill. Based on the volume calculations of basaltic detrital grains with different textures characteristic for pillow basalts, it could be established that pillow basalts dominated the igneous rocks in the source area of the Darnó Conglomerate on Darnó Hill already in the Miocene. Thus, this work shows that the lithological composition of a source area can be precisely outlined by a detailed petrographic analysis of the debris eroded from the immediate vicinity.
Chiral Minerals
Authors: Avnir David
Published: September 2024

Hundreds of minerals are chiral, that is, they appear in nature in two forms—left-handed and right-handed. Yet except for quartz, this key structural property has remained, by and large, in shadow in the world of minerals in research, in museum displays and for collectors. This review is devoted to providing a full picture of chiral minerals in nature. It starts with a general outline of the crystallographic background needed for the characterization of chiral minerals, continues with a detailed description of the many chemical and physical processes leading to their formation and follows with their chemical reactivities and transformations, with their physical properties and with the ways to analyze and identify them. Many tables with listings of various types of chiral minerals are provided. The “missing-glove” situation, in which the recognition that a chiral mineral appears in nature in two distinctly forms is, by and large, missing, is described, and it is hoped that this review will spark interest in this aspect of nature’s crystals.
Leaching Platinum Group Metals from Simulated Spent Auto-Catalyst Material Using Ozone and Hydrochloric Acid
Authors: Knight Marcus , van Wyk Petrie , Akdogan Guven , Bradshaw Steven
Published: September 2024

This paper reports the development of a process for leaching Pt, Pd, and Rh from simulated spent auto-catalyst material using ozone and hydrochloric acid in order to produce a pregnant leach solution that could be fed to an industrial precious metal refinery. The effects of O3 mass flow, initial acid concentration, and temperature were investigated using a Box–Behnken experimental design with three centre-point runs and a total leach time of 6 h. Set points of 3.34, 5.01, and 6.68 g/h; 1.0 M, 3.0 M, and 5.0 M; and 30, 60, and 90 °C were used for O3 mass flow, hydrochloric acid concentration, and temperature, respectively. The optimal extractions for Pt, Pd, and Rh were 80%, 85%, and 42%, respectively, at 5.01 g/h O3, 5.0 M HCl, and 90 °C. Statistical analyses indicated high dependencies of Pd and Rh on hydrochloric acid concentration and temperature, with only Pt displaying a significant dependence on O3 mass flow.
Oral Pre-Exposure Prophylaxis Innovative Interventions among Adolescent Girls and Young Women in South Africa: A Protocol Paper
Authors: Olifant Lerato Lucia , Phalane Edith , Phaswana-Mafuya Refilwe Nancy
Published: September 2024

Although South Africa was the first country to register and roll out oral pre-exposure prophylaxis (PrEP) biomedical human immunodeficiency virus (HIV) prevention intervention in sub-Saharan Africa (SSA), its uptake remains low, particularly among adolescent girls and young women (AGYW). The uptake of PrEP may have worsened during the Coronavirus disease 2019 (COVID-19) pandemic. Some innovative interventions to improve PrEP uptake among AGYW have been implemented. This study aims to evaluate the effectiveness of PrEP innovative interventions implemented during COVID-19 towards reducing the risk of HIV infection among AGYW in South Africa. An exploratory, descriptive design will be conducted to carry out four study objectives. Firstly, to carry out a systematic review of innovative PrEP interventions implemented during COVID-19 in SSA countries. Secondly, to conduct a stakeholder analysis to identify PrEP stakeholders and interview them on their views on the implemented interventions. Thirdly, to assess the implementation outcomes of the innovative interventions using document reviews and Consolidated Framework for Implementation Research. Fourthly, to develop a framework for an improved PrEP service delivery among AGYW. Qualitative data will be captured in ATLAS.ti software (Technical University, Berlin, Germany) version 23 and analysed via thematic analysis. A statistical software package (STATA) version 18 (College Station, TX, USA) will be used to capture quantitative data and analyse them via descriptive analysis. The generated evidence will be used towards the development of framework, guidelines, and policies to strengthen the uptake of, scale-up, and adherence to PrEP among AGYW.
Fueling the Firefighter and Tactical Athlete with Creatine: A Narrative Review of a Key Nutrient for Public Safety
Authors: Gonzalez Drew E. , Forbes Scott C. , Zapp Annette , Jagim Andrew , Luedke Joel , Dickerson Broderick L. , Root Alexandria , Gil Adriana , Johnson Sarah E. , Coles Macilynn , Brager Allison , Sowinski Ryan J. , Candow Darren G. , Kreider Richard B.
Published: September 2024

Background/Objectives: Firefighters, tactical police officers, and warriors often engage in periodic, intermittent, high-intensity physical work in austere environmental conditions and have a heightened risk of premature mortality. In addition, tough decision-making challenges, routine sleep deprivation, and trauma exacerbate this risk. Therefore, identifying strategies to bolster these personnel’s health and occupational performance is critical. Creatine monohydrate (CrM) supplementation may offer several benefits to firefighters and tactical athletes (e.g., police, security, and soldiers) due to its efficacy regarding physical performance, muscle, cardiovascular health, mental health, and cognitive performance. Methods: We conducted a narrative review of the literature with a focus on the benefits and application of creatine monohydrate among firefighters. Results: Recent evidence demonstrates that CrM can improve anaerobic exercise capacity and muscular fitness performance outcomes and aid in thermoregulation, decision-making, sleep, recovery from traumatic brain injuries (TBIs), and mental health. Emerging evidence also suggests that CrM may confer an antioxidant/anti-inflammatory effect, which may be particularly important for firefighters and those performing tactical occupations exposed to oxidative and physiological stress, which can elicit systemic inflammation and increase the risk of chronic diseases. Conclusions: This narrative review highlights the potential applications of CrM for related tactical occupations, with a particular focus on firefighters, and calls for further research into these populations.
Association between Poor Outcomes and Risk of Refeeding Syndrome among Patients Urgently Admitted to the High Dependency Unit: A Single-Center Cohort Study in Japan
Authors: Yoshida Minoru , Suzuki Masako , Wakatake Haruaki , Kurisu Miyuki , Saito Hiroki , Ohshima Yuki , Kaneko Mayumi , Fujiwara Kuniyasu , Masui Yoshihiro , Hayashi Koichi , Fujitani Shigeki
Published: September 2024

Background/Objectives: Refeeding syndrome (RFS) is recognized as a potentially fatal metabolic disturbance, particularly concerning for non-critically ill patients who do not receive frequent electrolyte assessments. Assessing the risk of developing RFS and implementing preventive strategies is essential in these cases. We investigated the proportion of risk and its association with prognosis in a high-dependency unit (HDU). Method: This observational study was conducted in a tertiary care hospital’s HDU in Japan. We consecutively enrolled all patients who had been admitted urgently to the HDU and hospitalized for three days or more. We evaluated the National Institute for Health and Clinical Excellence (NICE) RFS risk factors at admission and classified patients into four groups based on the modified NICE criteria. The primary outcome was 30-day in-hospital mortality. The secondary outcome was a composite of 30-day in-hospital mortality and transfer to the intensive care unit, or discharge to locations other than home. Using logistic regression, we assessed the association between the four risk groups and outcomes, using the no-risk group as a reference. Results: A total of 955 patients were analyzed, of which 33.1%, 26.7%, 37.8%, and 2.4% were classified into the no-risk, low-risk, high-risk, and very high-risk groups, respectively. The 30-day in-hospital mortality was 4.4%, 5.5%, 5.0%, and 21.7%, respectively (Log-rank trend test: p = 0.047). In multivariable logistic regression, adjusting for sepsis, comorbidities, and age, only the very high-risk group was associated with 30-day in-hospital mortality (odds ratio: 5.54, 95% confidence interval: 1.73–17.79) A similar association was observed for the secondary outcomes. Conclusions: For patients admitted urgently to the HDU, there may be an opportunity to improve outcomes for very high-risk patients through preventive strategies.
Selected Determinants of Diet Health Quality among Female Athletes Practising Team Sports
Authors: Gacek Maria , Wojtowicz Agnieszka , Banasik Marlena
Published: September 2024

This study’s aim was an analysis regarding selected determinants of diet health quality in a group of elite Polish female team sport players. Relationships were assessed between age, sport experience, personal resources and personality traits with regard to the Big Five model and the pro-Health (pHDI-10) and non-Healthy (nHDI-14) Diet Indices. This study was conducted among 181 women (median age—25 years; sport experience—7 years) with the use of the Beliefs and Eating Habits Questionnaire (KomPAN), Generalised Self-Efficacy Scale (GSES), Multidimensional Health Locus of Control Scale (MHLC-B) and NEO-PI-R personality inventory. Statistical analysis was carried out via the Wilcoxon signed-rank test, Kruskal–Wallis’s ANOVA, Spearman’s rank correlation coefficient and forward stepwise regression at a significance level of α = 0.05. Multivariate regression analysis indicated that the value of the pro-Health Diet Index (pHDI-10) was positively explained by professional experience and extraversion, while negatively by openness to experiences (12% of the pHDI-10 variance). In turn, a higher value of the non-Healthy Diet Index (nHDI-14) was associated with the discipline of basketball (2% of the nHDI-14 variance). In summary, the demonstrated diet health quality was low and the predictive significance of competitive experience as well as type of discipline and selected personality traits was exhibited for diet quality among female team sport players.
Omega-3 Supplementation in Coronary Artery Bypass Graft Patients: Impact on ICU Stay and Hospital Stay—A Systematic Review and Meta-Analysis
Authors: Ouagueni Asma , Shi Zumin , Shraim Mujahed , Al-Zoubi Raed M. , Zarour Ahmad , Al-Ansari Abdulla , Bawadi Hiba
Published: September 2024

Background/Objectives: Coronary artery bypass graft (CABG) is associated with inflammation and complications, potentially leading to prolonged ICU and hospital stays. Omega-3 PUFA has anti-inflammatory properties, thought to potentially reduce complications in CABG patients. This study aims to systematically review and meta-analyze the impact of perioperative omega-3 PUFA supplementation on total ICU and total hospital stays in CABG patients; Methods: Randomized controlled trials examining the effects of omega-3 PUFA supplementation (IV/oral) on ICU and hospital stays in CABG patients were included. Studies were searched for in PubMed, EMBASE, PsychINFO, CINAHL, and the Cochrane Central Register of Controlled Trial databases, along with hand searching of reference lists. The quality and risk of bias of the included studies were evaluated by two independent reviewers using the revised Cochrane risk-of-bias tool. Meta-analysis was performed using fixed or random effects models according to the level of heterogeneity by mean difference with their 95% confidence intervals; Results: Twelve studies were included in the qualitative analysis and seven in the meta-analysis. Omega-3 PUFA was associated with a significant reduction in days of hospital stay (−0.58 (95% CI −1.13, −0.04)). Subgroup analysis showed that only oral omega-3 PUFA supplementation resulted in a statistically significant reduction in length of hospitalization after subgroup analysis with MD −0.6 (95% CI −1.17, −0.04); Conclusions: This study suggests that perioperative omega-3 PUFA supplementation may reduce the length of hospitalization in CABG patients, especially when administered orally. However, the findings should be interpreted cautiously due to the high level of heterogeneity.
Orthorexia as an Eating Disorder Spectrum—A Review of the Literature
Authors: Łucka Izabela , Mazur Artur , Łucka Anna , Sarzyńska Izabela , Trojniak Julia , Kopańska Marta
Published: September 2024

Background: The purpose of this study is to compare and analyze research studies focused on orthorexia nervosa (ON) as a spectrum of eating disorders, and to summarize potential risk factors in different age and social groups. ON is characterized by an obsession with healthy eating, which leads to a restrictive diet and health problems. Methods: Due to a lack of comprehensive analyses, this review re-examined studies from 2006 to 2023, initially retrieving 53,134 articles. Upon refining the criteria and risk factors for eating disorders, 34 notable records were identified. These studies employed diagnostic tools such as ORTO and BOT, focusing on risk factors for ON. Results: Results indicate that individuals suffering from eating disorders, losing weight, exercising heavily, developing relationship problems, and suffering from body dysmorphic disorder are at high risk of developing ON. A significant correlation was found between ON, BMI, and gender, but not between ON and OCD. Interestingly, ON symptoms appear to overlap with those of other eating disorders, such as anorexia and bulimia, especially in terms of obsessive control over dieting and fear of gaining weight, indicating a close relationship between the two. Conclusions: Interestingly, orthorexia nervosa may serve as a coping mechanism for anorexia, providing a sense of control. However, further research on its long-term effects is required.
Oral Trehalose Intake Modulates the Microbiota–Gut–Brain Axis and Is Neuroprotective in a Synucleinopathy Mouse Model
Authors: Pradeloux Solène , Coulombe Katherine , Ouamba Alexandre Jules Kennang , Isenbrandt Amandine , Calon Frédéric , Roy Denis , Soulet Denis
Published: September 2024

Parkinson’s disease (PD) is a neurodegenerative disease affecting dopaminergic neurons in the nigrostriatal and gastrointestinal tracts, causing both motor and non-motor symptoms. This study examined the neuroprotective effects of trehalose. This sugar is confined in the gut due to the absence of transporters, so we hypothesized that trehalose might exert neuroprotective effects on PD through its action on the gut microbiota. We used a transgenic mouse model of PD (PrP-A53T G2-3) overexpressing human α-synuclein and developing GI dysfunctions. Mice were given water with trehalose, maltose, or sucrose (2% w/v) for 6.5 m. Trehalose administration prevented a reduction in tyrosine hydroxylase immunoreactivity in the substantia nigra (−25%), striatum (−38%), and gut (−18%) in PrP-A53T mice. It also modulated the gut microbiota, reducing the loss of diversity seen in PrP-A53T mice and promoting bacteria negatively correlated with PD in patients. Additionally, trehalose treatment increased the intestinal secretion of glucagon-like peptide 1 (GLP-1) by 29%. Maltose and sucrose, which break down into glucose, did not show neuroprotective effects, suggesting glucose is not involved in trehalose-mediated neuroprotection. Since trehalose is unlikely to cross the intestinal barrier at the given dose, the results suggest its effects are mediated indirectly through the gut microbiota and GLP-1.
Investigating Causal Associations between the Gut Microbiota and Dementia: A Mendelian Randomization Study
Authors: Xiong Zhi-Yuan , Li Hong-Min , Qiu Cheng-Shen , Tang Xu-Lian , Liao Dan-Qing , Du Li-Ying , Lai Shu-Min , Huang Hong-Xuan , Zhang Bing-Yun , Kuang Ling , Li Zhi-Hao
Published: September 2024

Background: The causal association of specific gut microbiota with dementia remains incompletely understood. We aimed to access the causal relationships in which one or more gut microbiota account for dementia. Method: Using data from the MiBioGen and FinnGen consortia, we employed multiple Mendelian randomization (MR) approaches including two-sample MR (TSMR), multivariable MR (MVMR), and Bayesian model averaging MR to comprehensively evaluate the causal associations between 119 genera and dementia, and to prioritize the predominant bacterium. Result: We identified 21 genera that had causal effects on dementia and suggested Barnesiella (OR = 0.827, 95%CI = 0.722–0.948, marginal inclusion probability [MIP] = 0.464; model-averaged causal estimate [MACE] = −0.068) and Allisonella (OR = 0.770, 95%CI = 0.693–0.855, MIP = 0.898, MACE = −0.204) as the predominant genera for AD and all-cause dementia. Conclusions: These findings confirm the causal relationships between specific gut microbiota and dementia, highlighting the necessity of multiple MR approaches in gut microbiota analysis, and provides promising genera as potential novel biomarkers for dementia risk.
The Immunomodulatory Effects of Selenium: A Journey from the Environment to the Human Immune System
Authors: Sadler Rebecka A. , Mallard Bonnie A. , Shandilya Umesh K. , Hachemi Mohammed A. , Karrow Niel A.
Published: September 2024

Selenium (Se) is an essential nutrient that has gained attention for its impact on the human immune system. The purpose of this review is to explore Se’s immunomodulatory properties and to make up-to-date information available so novel therapeutic applications may emerge. People acquire Se through dietary ingestion, supplementation, or nanoparticle applications. These forms of Se can beneficially modulate the immune system by enhancing antioxidant activity, optimizing the innate immune response, improving the adaptive immune response, and promoting healthy gut microbiota. Because of these many actions, Se supplementation can help prevent and treat pathogenic diseases, autoimmune diseases, and cancers. This review will discuss Se as a key micronutrient with versatile applications that supports disease management due to its beneficial immunomodulatory effects. Further research is warranted to determine safe dosing guidelines to avoid toxicity and refine the application of Se in medical treatments.
The Kumagai Method: Feeding Techniques Using the Pigeon Baby Cleft Palate Bottle
Authors: Ueki Shingo , Kumagai Yukari , Hirai Yumi , Nagatomo Eri , Miyauchi Shoko , Inoue Takuro , An Qi , Tashiro Eri , Miyata Junko
Published: September 2024

Background/Objectives: This study aimed to identify the P-bottle feeding techniques systematically organized by Ms. Kumagai, an expert in nursing care for children with a cleft lip and/or palate (CLP), which were developed as she gained expertise in feeding affected children. Methods: We recruited three nurses who had mastered the Kumagai method for feeding with a P-bottle. Through analysis of participants’ voices and videos during interviews, we focused on aspects such as dealing with a closed mouth, inserting the nipple in cases of unilateral and bilateral CLP, dealing with the child’s movements after insertion, and key considerations when squeezing the bottle. Results: The interview analyses revealed numerous techniques used by nurses to manage the difficulties encountered while feeding children, ensuring successful provision of nourishment. Specifically, the nurses employed techniques such as placing the nipple along the midline of the child’s tongue and varying the application of force on the nipple depending on the cleft type. The nurses reported that the objectives of these techniques were to prevent ulcer formation and encourage the use of the tongue, simulating original feeding movements. Conclusions: We explored feeding techniques and the management of associated challenges. Our results suggest that the “Kumagai Method” could be valuable in improving feeding practices.
Promising Phytoconstituents in Antiangiogenesis Drug Development
Authors: Abu-Reidah Ibrahim M. , Taamalli Amani
Published: September 2024

Angiogenesis, the process of forming new blood vessels from existing ones, is crucial in both physiological and pathological conditions, such as tumor growth, metastasis, and inflammatory disorders. Targeting angiogenesis has emerged as a promising therapeutic strategy. Recent research has increasingly focused on the role of bioactive components found in food in regulating angiogenesis, although there are certain limitations. This review provides a comprehensive examination of the origins, composition, pharmacological activities, and mechanisms of action of these components in medicinal foods, reflecting the growing intersection of medicine and nutrition. The goal is to aid in preventing angiogenesis-related complications and fostering healthier habits. The insights offered in this review aim to advance the development of effective, low-toxicity antiangiogenic drugs. Additionally, there has been a notable rise in interest in plant-derived compounds with antiangiogenic properties. This review investigates the potential of phytoconstituents from plants as drug candidates targeting angiogenesis, exploring their mechanisms of action, the research conducted thus far, and the challenges associated with transitioning these compounds into clinical applications.
Hepatitis C Virus Infection in Europe
Authors: Simão Margarida , Gonçalves Cristina
Published: September 2024

The Hepatitis C Virus (HCV) is a significant public health challenge in European countries. Historically, healthcare-related procedures were the primary source of HCV infection in Europe. However, with the implementation of blood safety programs, injection drug use has become the main transmission route. The infection’s distribution and genotype prevalence vary widely across the continent. Even with the availability of highly effective direct-acting antiviral (DAA) therapies, HCV infection is far from being controlled. A significant proportion of patients remain undiagnosed, contributing to the ongoing transmission of the virus. Additionally, several barriers hinder the widespread use of DAAs, including high treatment costs, stigma, poor linkage to care, and considerable geographical variations in prevalence and transmission routes. The World Health Organization has set ambitious targets to reduce liver-related deaths, decrease new viral hepatitis infections, and ensure that 90% of infected individuals are diagnosed by 2030. However, most European countries face challenges, highlighting the need for screening programs, funding mechanisms, and public health strategies to effectively control HCV infection in Europe.
Molecular Identification and Bioinformatics Analysis of Anaplasma marginale Moonlighting Proteins as Possible Antigenic Targets
Authors: Quiroz-Castañeda Rosa Estela , Aguilar-Díaz Hugo , Coronado-Villanueva Eduardo , Catalán-Ochoa Diego Israel , Amaro-Estrada Itzel
Published: September 2024

Background: Diseases of veterinary importance, such as bovine Anaplasmosis, cause significant economic losses. Due to this, the study of various proteins of the causal agent Anaplasma marginale has focused on surface proteins. However, a vaccine for this disease is not yet available. To this end, in this work, moonlighting proteins (MLPs) are presented as an alternative approach for the design of immunogens against A. marginale. Methods: The proteins of the strain MEX-15-099-01 were analyzed, and its MLPs were identified. Subsequently, four virulence-associated MLP genes were selected and identified using PCR. The proteins were analyzed using a structural homology approach and the collection of B-cell epitopes was predicted for each MLP. Finally, a pair of AmEno peptides were synthesized and the antigenic potential was tested using an iELISA. Results: Our bioinformatics analysis revealed the potential of AmEno, AmGroEl, AmEF-Tu, and AmDnaK proteins as promising candidates for designing immunogens. The PCR allowed the gene sequence identification in the genome of the strain MEX-15-099-01. Notably, AmEno-derived synthetic peptides showed antigenicity in an ELISA. Conclusions: Our study has shed light on the potential use of MLPs for immunogen design, demonstrating the antigenic potential of AmEno.
Consequences of the COVID-19 Pandemic on the Incidence, Management and Outcomes of Staphylococcus aureus Bacteraemia: Experience in a Spanish Hospital
Authors: Lorenzo-Hernández Elizabeth , Rivas-Ruiz Francisco , Del Arco-Jiménez Alfonso
Published: September 2024

This work aims to assess the impact of the COVID-19 pandemic on the mortality and incidence of complications in patients with bacteraemia due to Staphylococcus aureus (BSA). All episodes of BSA at the Costa del Sol University Hospital (Marbella, Spain) were recorded during the acute phase of the COVID-19 pandemic (March 2020–March 2022) and compared with those in a previous period (February 2018–February 2020). Demographic, clinical and prognostic variables were recorded. The outcomes were measured as 14- and 30-day mortality and the incidence of complications/death. Mortality during the pandemic was 28.7% at 14 days and 35% at 30 days, while in the pre-pandemic group, it was 18.9% and 23.3%, respectively. For overall complications/deaths, the incidence rate was higher in the pandemic group, with 42.7%. No significant differences were observed between groups. Seventeen patients with COVID-19 were identified, with mortality rates of 64.7% and 70.6% at 14 and 30 days. Multivariate analysis established the presence of sepsis at diagnosis as a predictor of mortality, but not BSA, during the pandemic phase. In conclusion, BSA is a disease with high mortality, which was slightly higher during the pandemic phase. No differences were found in adherence to the bundle in our centre.
Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria
Authors: Kubanek Alicja , Sulima Małgorzata , Szydłowska Aleksandra , Sikorska Katarzyna , Renke Marcin
Published: September 2024

Malaria is a major international public health problem. The risk of acquiring malaria varies depending on the intensity of transmission and adherence to mosquito precautions and prophylaxis recommendations. Severe malaria can cause significant multiorgan dysfunction, including acute kidney injury (AKI). Intravenous artesunate is the treatment of choice for severe malaria in non-endemic areas. One of the possible events connected with the lifesaving effects of artemisins is post-artesunate haemolysis (PADH), which may be potentially dangerous and under-recognised. We present a case of a seafarer with severe Plasmodium falciparum malaria complicated with AKI and PADH, with a good response to steroid treatment. This case highlights the need for malaria prophylaxis in business travellers, e.g., seafarers to malara-endemic regions, and close supervision of patients with malaria even after the completion of antimalarial treatment due to the possibility of late complications.
Beneficial Effects of Nutraceuticals, Especially Polyphenols on Canine Health
Authors: Ruiz-Cano Domingo , Arnao Marino B.
Published: September 2024

The use of nutraceuticals, mainly phytogenics, is increasingly widespread in animal nutrition, especially in dogs. The materials typically used to provide these very diverse natural compounds come from plants, but lately algae and fungi have also been used. In animal nutrition, these compounds are applied to obtain better results in the production and stability of feed and also as biofunctional substances with benefits for animal health. Polyphenols are natural compounds from the secondary metabolism of plant matter present in animal food (e.g., seeds and nuts, fruits, vegetables, herbs/aromatic plants, spices, cereals, and vegetable oils, among others). Most of the biological effects of these compounds associated with health benefits have been attributed to their antioxidant potential because they can protect cellular elements against oxidative injury, reducing the risk of dysfunctions and diseases associated with oxidative processes. Polyphenols are constituted by multiple families of substances with wide applications in pet therapy and nutrition. In this work, we review the most relevant phytogenic polyphenols, exploring their characteristics, sources, and implications for canine health. Our focus includes the effects on gastrointestinal functions and its microbiota, as well as aspects such as obesity, diabetes, and fat metabolism. Additionally, we examine their impact on cardiovascular, neurological, and immunological systems, along with their potential anti-oncogenic role. Finally, we discuss the overall role of polyphenols in dog diets and their future implications.
Common Mitochondrial Targets of Curcumin and Cinnamic Acid, the Membrane-Active Natural Phenolic Compounds
Authors: Fedotcheva Tatiana A. , Beloborodova Natalia V. , Fedotcheva Nadezhda I.
Published: September 2024

Background: Research has shown the multiple actions of curcumin on different cell systems, including enzymes and mitochondria. The detected effects of curcumin on mitochondria are diverse, ranging from protective to toxic. Objectives: In this present work, the influence of curcumin, as well as cinnamic acid, which is a microbial metabolite and a possible product of the microbial breakdown of curcumin, on isolated mitochondria, was investigated. Methods: Membrane potential, swelling, respiration, and calcium retention capacity were studied using selective electrodes, fluorescence and spectral methods. Results: It was found that curcumin at low concentrations (10–20 μM) activated the opening of the calcium-dependent permeability transition pore (mPTP) and decreased the calcium retention capacity and threshold concentrations necessary for the mPTP opening. Moreover, curcumin caused a concentration-dependent stepwise decrease in the membrane potential, accompanied by the activation of respiration and a decrease in oxidative phosphorylation, which indicates that curcumin is a typical mitochondrial uncoupler. The uncoupling effect strongly depended on the concentration of curcumin, which also increased, stepwise, from weak uncoupling at 25 µM to complete uncoupling at 75–100 µM. Cinnamic acid had similar effects, with the exception of the depolarizing effect, at concentrations that were an order of magnitude higher. Conclusions: Presumably, the uncoupling action of curcumin is a priming event that modulates any energy- and redox-dependent mitochondrial functions, from positive stimulation to toxic disorder. This effect can also underlie the curcumin-induced changes in different cellular processes and be achieved by targeted delivery of curcumin to certain cells, bypassing the microbiota.
Selection Rules of Linear and Nonlinear Polarization-Selective Absorption in Optically Dressed Matter
Authors: Feldman Michael , Even Tzur Matan , Cohen Oren
Published: September 2024

Dynamical symmetries of laser-dressed matter determine the selection rules that influence its absorption spectrum. We explore selection rules for polarization-sensitive absorption in Floquet matter, using Floquet group theory in synthetic dimensions. We present comprehensive tables of selection rules that polarization-structured light impose on Floquet dark states and Floquet dark bands. Notably, our tables encompass nonlinear absorption for all nonlinear orders, revealing that different nonlinear orders follow distinct polarization selection rules, potentially leading to polarization-tunable optical filters.
Ultrahigh-Reflectivity Circularly Polarized Mirrors Based on the High-Contrast Subwavelength Chiral Metasurface
Authors: Cheng Bo , Jiang Botao , Zou Yuxiao , Song Guofeng
Published: September 2024

The circularly polarized laser sources are core components for many optical applications such as biomedicine, quantum technology, and AR/VR. However, conventional techniques make it difficult to further diminish the size of circularly polarized lasers. Thus, the high-contrast subwavelength chiral metasurface (HCCM) with a 980 nm operating wavelength is numerically investigated. The HCCM is composed of chiral metasurfaces modulating the circular dichroism of reflectance and 6 pairs of Distributed Bragg Reflectors (DBR) with 55% reflectivity. The reason that the HCCM has an ultra-high reflectivity (99.9%) at the operating wavelength of 980 nm is the combination of the optical refractive index difference between the GaAs metasurface and the AlOx substrate and weak destructive interference in the AlOx support layer. In addition, the circular dichroism of the chiral metasurfaces (2.1%) is mainly caused by the displacement of two square air holes in opposite directions, thus transforming the unit cell of the metasurface from C2 symmetry to chiral symmetry. The reflector has the advantages of a simple structure and miniaturization, which is expected to greatly reduce the fabrication difficulty and cost of the circular polarization VCSELs.