bluuebunny/crossref_metadata_2025 huggingface dataset:
Co-occurrence of Traditional and Cyberbullying Victimization Among Adolescents: Characteristics, Psychological Difficulties, and Resilience
Authors: Gefen Amir , Gross Zehavit , Heiman Tali
Published: September 2024

This study examines whether students’ experience of combined victimization, the experience of both traditional bullying and cyberbullying, is correlated with psychological difficulties. Additionally, the study examines whether Israeli students who cope with combined victimization differ in their resilience resources from students who experience solely traditional bullying, cyberbullying, or neither. Participants included 430 students aged 13–15 years from four Israeli schools who completed self-report questionnaires. The study results indicate that students who experience combined victimization experience significantly greater psychological difficulties than students who experience traditional bullying and students who experience no victimization. Moreover, the extent of emotional self-efficacy and social support among students who experienced combined victimization was significantly lower than those who experienced no victimization. Implications of the results are discussed.
On Ramsey numbers for trees versus fans of even order
Authors: Sherlin Intan , Saputro Suhadi Wido , Baskoro Edy Tri , Oktariani Finny
Published: September 2024

Given two graphs G and H. The graph Ramsey number R(G, H) is the least natural number r such that for every graph F on r vertices, either F contains a copy of G or F̅ contains a copy of H. A vertex v is called a dominating vertex in a graph G if it is adjacent to all other vertices of G. A wheel Wm is a graph consisting one dominating vertex and m other vertices forming a cycle. A fan graph F1,m is a graph formed from a wheel Wm by removing one cycle-edge. In this paper, we consider the graph Ramsey number R(Tn,F1,m) of a tree Tn versus a fan F1,m. The study of R(Tn,F1,m) has been initiated by Li et. al. (2016) where Tn is a star, and continued by Sherlin et. al. (2023) for Tn which is not a star and fan F1,m with even m ≤ 8. This paper will give the graph Ramsey numbers R(Tn,F1,m) for odd m ≤ 8.
Effect of Cultivation Techniques in The Dry and Rainy Seasons on The Quality of The Seaweed Caulerpa racemosa
Authors: Darmawati Darmawati , Soedibya Petrus Hary Tjahja , Anwar Asni , Murni Murni , Tang Beddu
Published: September 2024

The seaweed Caulerpa racemosa has great potential to be developed because it has economic value and potential as a functional food. This seaweed contains nutrients, including protein, carbohydrates, polyunsaturated fatty acids, fiber minerals, and antioxidants. The availability of seaweed is still very dependent on nature and has not been appropriately cultivated. The planting season and appropriate cultivation methods will influence seaweed's quality/nutritional content. This research aims to analyze the nutritional content of seaweed C. racemosa cultivated in different growing seasons. The research method used a floating raft system with a completely randomized design and a factorial pattern carried out in two seasons, namely the dry and rainy seasons. Proximate analysis was carried out to determine the nutritional composition of seaweed C. racemosa, including protein, crude fiber, water, ash, fat, and carbohydrate (NFE). Next, it was analyzed using ANOVA with a further test with Tukey. The research results showed differences in the nutritional composition of seaweed C. racemosa from each treatment cultivated in the dry and rainy seasons. The nutritional composition of seaweed C. racemosa best treatment is found in the plant spacing of 30 cm with a depth of 50 cm in the dry season with the nutritional content namely protein (13.8%), NFE (20.75%), crude fiber (15.71%), a fluctuating fat content of 0.16-1.42%, highest ash (34.69%), water content (35%), moderate in the rainy season namely: protein (10.8%), BETN (10.78%), crude fiber (12.33%), fat content fluctuates (0.18-1.06%), highest ash (30.21%), water content (41.01%).
Predictive Maintenance for Critical Infrastructure Security
Authors: Olaoluwa Favour , Potter Kaledio
Published: September 2024

Predictive maintenance (PdM) represents a transformative approach to ensuring the security and reliability of critical infrastructure systems. This proactive maintenance strategy leverages advanced data analytics, machine learning, and sensor technology to anticipate and address potential failures before they occur. By continuously monitoring the health of infrastructure components and analyzing performance data, predictive maintenance enables timely interventions, minimizes unplanned downtimes, and enhances overall system resilience. This paper explores the application of predictive maintenance in safeguarding critical infrastructure, focusing on its impact on security, operational efficiency, and cost-effectiveness. Case studies demonstrate how PdM has been successfully implemented across various sectors, including transportation, energy, and utilities, highlighting its role in mitigating risks and extending the lifespan of essential assets. The findings underscore the importance of integrating predictive maintenance into security strategies to protect vital infrastructure from emerging threats and ensure uninterrupted service delivery.
The Adaptation of Laws in Physics: Adaptation of Mathematical Models in Physics
Authors: Croitoru Anatolie
Published: September 2024

This paper is a part of the broader research on “Adaptation of Laws in Science” and explores the limitations and challenges involved in adapting mathematical concepts to describe natural reality in physics. Specifically, the analysis focuses on two major examples: Euler's exponential laws and spacetime dilation derived from Lorentz transformations. By examining these concepts, the paper emphasizes that some complex laws are not universally applicable for deeper studies of nature, as they originate from mathematics and are correct only for specific parts of nature to which they have been adapted. These complex laws are particularly unsuitable where there is limited information available for adaptation. Therefore, without appropriate adaptations and a deep understanding of the physical context under investigation, the direct use of complex laws can lead to incorrect results. It is essential to avoid excessive generalization of these laws, once they become part of physics, unless a corresponding adaptation to the research context can be made. Furthermore, this paper supports the correctness of relativity theories by invoking that, like Euler's exponential growth theory, they were initially mathematical concepts. However, the nature of mathematics coincided with that of the phenomena in our universe, although through certain adaptations.
Development of LA-MRSA Loads in Pigs and Pig Stables during the Fattening Period
Authors: Pedersen Karl , Nielsen Martin Weiss , Fertner Mette Ely , Gongora Carmen Espinosa , Bækbo Poul J.
Published: September 2024

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is widespread in European pig production, and although it is not an important food-borne pathogen, it constitutes a potential occupational hazard to farm workers and possibly to their household members. Farm workers can be exposed to LA-MRSA via direct contact with pigs and via airborne transmission. Bacteria can then be carried home in the nose or on the skin, potentially exposing household members. Therefore, it is important to consider LA-MRSA in a one-health context, studying human exposure by investigating LA-MRSA levels in pigs and in the farm environment, air, and dust.
In the present investigation, we quantified LA-MRSA levels in nasal swab samples, air samples, and dust, collected at three different time points in a farm rearing pigs from appr. 30 kg until slaughter. Sampling was repeated across seven batches of pigs, resulting in the analysis of 504 nasal swab samples, together with air and dust samples. LA-MRSA was cultured and quantified on MRSA2 agar plates.
Our findings revealed a significant batch-to-batch variation and a significant decrease of 94.1 % in LA-MRSA levels during the rearing period. Despite this decrease, all nasal swab samples tested positive, with the highest level reaching 353,000 cfu in a sample. In the 42 air samples collected, we found low to moderate LA-MRSA levels, with a maximum of 568 and an average of 63 cfu/m3. In the 28 dust samples collected during the second and third sampling periods, LA-MRSA counts were high, reaching up to 37,272 cfu/g, with an average of 17,185 cfu/g. The results indicate that while LA-MRSA levels in pigs gradually decrease with age and reach low levels before slaughter, the bacterium remains highly abundant in dust, which may pose an occupational hazard to farm workers.
A Journey through the Minefield of the Discovery and Characterization of LR-RNA/LAT
Authors: Ghiasi Homayon
Published: September 2024

Scientific knowledge evolves in small steps, with occasional backsteps to correct inaccuracies, all occurring within a competitive environment. This perspective for the first time looks at the history of latency-related RNA (LR-RNA) that was later renamed latency-associated transcript (LAT). At the 1986 International Herpesvirus Workshop (IHW) meeting in Leeds, England, Daniel L Rock and Anthony B Nesburn first reported the discovery of human herpes virus 1 (HSV-1) latency-related (LR)-RNA that is antisense to ICP0. Less than a month after the IHW meeting a paper was submitted to Science magazine and 8 months later appeared in print thanking “D. Rock for suggesting RNA complementary to the ICP0 message may be present in latently infected cells”. This perspective is not a review of LAT literature but intends to clarify the timeline of LAT discovery and subsequent breakthroughs such as reactivation, apoptosis, CD8+ T cell exhaustion, and LAT expression in different cell types detected during latency. While many review articles have been written about LAT since 1987, the most comprehensive and balanced review about LAT was written by Dr. David Bloom’s group (1). In this overview, I will discuss our original collaboration with Dr. Dan Rock and subsequent work that our group performed, which is still ongoing. Finally, I will discuss the controversies associated with LAT from its inception to current times.
Rebound Effects caused by Artificial Intelligence and
Automation in Private Life and Industry
Authors: Ertel Wolfgang , Bonenberger Christopher
Published: September 2024

Many tasks in a modern household are done by machines like e.g. a dishwasher or a
vacuum cleaner and in the near future most household tasks can be done by smart service robots.
This relieves the residents who in turn can enjoy their free time. This newly gained free time turns
out to cause the so called spare time rebound effect due to more resource consumption [1,2]. We
roughly quantify this rebound effect and propose a CO2 -budget model to reduce or even avoid it. In
modern industry, automation and AI take over work from humans, leading to higher productivity of
the company as a whole. This is the main reason for economic growth which leads to environmental
problems due to higher consumption of natural resources. We show that, even though the effects of
automation at home and in the industry are different (free time versus higher productivity) in the
end they both lead to more resource consumption and environmental pollution. We discuss possible
solutions to this problem such as carbon taxes, emissions trading systems and a carbon budget.
OOT Therapy Combined with Porcine Collagen Injection in Patients with Low Back Pain: The Booster to Increase Short- and Long-Term Efficacy
Authors: De Pascalis Manuela , Mulas Susanna , Sgarbi Liliana
Published: September 2024

Intervertebral disc degeneration is one of the most frequent causes of lower back pain, and lum-bosciatica puts a strain on healthcare systems around the world. For years, ozone therapy has been used with excellent results in intervertebral disc pathology and in patients with low back pain (LBP). Treatment with intramuscular paravertebral ozone injection is based on the combination of the anti-inflammatory action with the action of accelerating the dehydration process of the cartilage tissue of the disc, and on the action of general oxygenation of the tissues. We know that the main functional structures involved in the onset of pain in LBP are rich in type 1 collagen: the fascial system, the annulus fibrosus and the zygo-apophyseal joints. In all these facilities, collagen repair and regeneration processes deserve an important mention as collagen turnover plays a fundamental role in the well-being of patients with LBP. In particular, in vitro studies have demonstrated the positive action of porcine type 1 collagen in the face of extracellular matrix (ECM) remodeling and homeostasis. In fact, the tissue modification, associated with LBP, could also suggest an indication for combined ozone/collagen treatment in patients with LBP. However, no studies regarding combined ozone treatment with collagen have been performed in patients with LBP. The present work compared two different arms (10 lumbar patients each) Oxygen-Ozone Therapy (OOT) vs OOT plus Porcine Collagen Type 1 Injections (COL I, MD-LUMBAR). NSR, physiological function (trunk movement) and disability questionnaire were studied for all patients before, during and after treatments. Patient follow-up was performed again 6 months after the last treatment. Statistical analysis tests revealed significant differences compared to the two arms. In which, the dual choice (OOT+COL I), demonstrated a booster effect in both short-term and long-term NSR (p
Fair Federated Learning
Authors: Talebi Amirreza
Published: September 2024

Optimization is critical in various fields like smart vehicles, and transportation. Federated Learning (FL) has emerged as an effective approach in the coordination of autonomous vehicles, but traditional methods such as FedAvg can create performance disparities across clients. This paper addresses this fairness issue through the $q$-Fair Federated Learning ($q$-FFL) framework, adjusting model performance across clients using a tunable fairness parameter. We propose a modified FedAvg algorithm for $q$-FFL that maintains comparable convergence rates, ensuring more balanced client outcomes. Additionally, we explore incentive mechanisms in FL using a Stackelberg game model, incorporating a fairness coefficient to encourage equitable participation. Building on prior works, we redefine client utility functions to address communication and computation costs, ensuring fair resource allocation. The proposed framework achieves both global and local fairness, maintaining a unique Nash equilibrium in the modified game setting.
Comparative Study of Microwave and Resistance Heating for the Efficient Thermal Desorption of Mineral Oil from Contaminated Soils
Authors: Xu Jun , Liu Tao Song , Chen Ming Chuan
Published: September 2024

The contamination of soils by mineral oils presents a significant environmental challenge, particularly due to the widespread use of petroleum products in various industrial sectors. This study investigates the efficiency of microwave heating compared to conventional resistance heating for the thermal desorption of mineral oil from contaminated soils. Experimental results demonstrated that microwave heating offers superior performance in terms of pollutant removal efficiency, energy consumption, and preservation of soil's physical and chemical properties. The study further conducted a kinetic analysis of the desorption process, revealing that microwave heating follows a first-order kinetic model and requires lower activation energy than conventional methods. The findings suggest that microwave-assisted thermal desorption is a highly effective and energy-efficient technology for soil remediation, providing a potential alternative to conventional techniques. This research offers valuable insights into optimizing thermal desorption processes for environmental remediation, with implications for broader applications in soil treatment.
Biological and technological aspects of food enrichment with dietary fiber
Authors:   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Pilipenko V.I. , Isakov V.A. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Perova I.B. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Vorobyeva V.M. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Kochetkova A.A. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation
Published: September 2024

Epidemiological studies demonstrate the health benefits of high dietary fiber intake. However, the propaganda high fiber intake by increasing the proportion of fruits and vegetables in the diet are ineffective. Dietary fiber can be used in fortified foods. This review shows the current data on the technological possibilities of fortification with dietary fiber of cereals, dairy products and meat products. The data on successful and unsuccessful results of enrichment of individual food products with different types of dietary fiber are presented. Key words: healthy diet, fortified foods, dietary fiber, fortification technologies
Analysis of bioelement intake with food in Khanty-Mansiysk residents with arterial hypertension
Authors:   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation, Sharifov M.I.
Published: September 2024

Objective. To evaluate the intake of calcium, magnesium, potassium, copper, zinc, selenium, iron, and manganese with food in Khanty-Mansiysk residents suffering from arterial hypertension (AH). Patients and methods. The study included 50 adult non-indigenous residents of Khanty-Mansiysk aged 36–48 years with a diagnosis of AH, including 28 men and 22 women. Nutritional intakes were assessed via 24-h dietary recall using the program “ASPON-nutrition”. The intake of Ca, Mg, K, Cu, Zn, Se, Mn, and Fe was studied. The results were compared with the norms of physiological requirements (NPR). Results. Deficient intake of Ca, Mg, K, Cu, Zn (74–88% of NPR) was revealed, especially Se (49.3% of NPR in men, 56.4% of NPR in women) combined with optimal intake of Mn and excessive intake of Fe (121% of NPR in men, 102% of NPR in women). Conclusion. Given the numerous beneficial effects on several mechanisms associated with AH, a healthy diet that provides an optimal amount of bioelements may be an important strategy for blood pressure control. To prevent the development of diseases associated with oxidative stress in residents of the North, namely AH, it is necessary to create conditions for optimal intake of bioelements involved in the regulation of blood pressure and antioxidant protection of the body, in combination with the use of biologically active food supplements and food products enriched with bioelements. Key words: Northern Region, patients with arterial hypertension, dietary intake, chemical elements
Celiac disease: old problem, new solutions
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin А.I. ,   Belgorod State Research University, Belgorod, Russian Federation, Bystrova V.I. ,   Novosibirsk State University, Novosibirsk, Russian Federation, Schreiner Е.V. ,   Novosibirsk State University, Novosibirsk, Russian Federation,   Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Nikolaychuk K.M. ,   Novosibirsk State University, Novosibirsk, Russian Federation, Lifshits G.I. ,   Novosibirsk State University, Novosibirsk, Russian Federation,   Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Denisov M.Yu. ,   Novosibirsk State University, Novosibirsk, Russian Federation
Published: September 2024

Celiac disease (CD) is a well-studied disease among disorders associated with human leukocyte antigen (HLA). The prevalence of CD is about 0.7–1.4% of the population. This condition is multi-organ, because in addition to intestinal symptoms, there are a large number of extra-intestinal manifestations. CD occurs in people with a genetic predisposition. The disease is characterized by hypersensitivity to grain gluten proteins. The diagnosis can be made by detecting highly specific autoantibodies to transglutaminase 2 in the blood. All patients with CD should follow a gluten-free diet throughout their lives. Key words: celiac disease; gluten-free diet; gluten; transglutaminase 2
Endocrine and andrological pathology in adolescent boys from chronic iodine-deficient areas
Authors:   Dagestan State Medical University, Makhachkala, Russian Federation, Kamalov K.G.
Published: September 2024

Objective. To analyze the structure of endocrine and andrological pathology and the impact of iodine deficiency on puberty in adolescent boys living in different ecological and geographical areas of the Republic of Dagestan. Patients and methods. The study included 6513 adolescent boys. The degree of iodine saturation in the Republic of Dagestan was estimated. Renal urinary excretion of iodine was determined in 3457 patients using a flow spectrometer with a System-103 microprocessor (Cibe Corniny, UK). Statistical processing was performed using clinical signs; mean values, standard error of the mean, standard deviations, and coefficient of variation were calculated using MS Visual Fox Pro 9.0, Excel and Biostat 4.03. The significance of differences between the rates of qualitative characteristics was determined by the Dunn index. Results. The analysis of iodine deficiency in different ecological and geographical areas of the Republic of Dagestan revealed that 9.2% of territories in the plain area have severe iodine deficiency. In the mountainous area, 29% of territories have a median severe ioduria. In boys aged 14–17 years, the rate of reproductive disorders increased in territories with different severity of iodine deficiency: moderately severe – 89.6%, mild to moderate – 60.0% (p < 0.05). The clinical and epidemiological analysis of endocrine and andrological pathology showed the severity of iodine deficiency: the rate of endocrine and andrological pathology moderately correlates with the severity of iodine deficiency (R = 0.5), and the leading reproductive pathologies in the Republic of Dagestan are: 1) varicocele, 2) delayed puberty, 3) late diagnosed cryptorchidism. Conclusion. The most frequently detected endocrine and andrological pathology is varicocele, followed by delayed puberty and cryptorchidism. Endocrine and andrological pathology was diagnosed 2.2 times more often in moderately severe iodinedeficient areas of the Republic of Dagestan. Key words: iodine deficiency, ecological and geographical areas, Dagestan, thyroid gland, endocrine and andrological pathology, puberty
Sistem Informasi Penjualan Produk Olahraga Berbasis Web Dengan Fitur Chatbot di Toko MJ Sport
Authors: Syafira Ad'haniata Intan , Nugroho Yusuf Sulistyo
Published: September 2024

Toko MJ Sport adalah salah satu toko yang menjual peralatan olahraga voli yang berada di wilayah Jakarta Barat. Kegiatan pencatatan pada MJ Sport masih dilakukan secara manual, tentu hal ini membuat pemilik toko kesulitan dalam mengelola data-data penjualan sehingga membutuhkan waktu dan rentan akan kesalahan pencatatan. Penelitian ini bertujuan untuk membuat sistem informasi penjualan yang berbasis website yang dikembangkan dengan metode Rapid Application Development (RAD) yang meliputi 4 fase yaitu fase perencanaan kebutuhan (requirements planning), fase perancangan (user design), fase konstruksi (construction) dan fase pengujian (cutover). Sistem ini sudah melewati 2 metode pengujian yaitu Black Box Testing dan System Usability Scale (SUS). Pada pengujian menggunakan metode Black Box didapatkan fungsionalitas sistem sudah berjalan dengan semestinya, sedangkan pada pengujian menggunakan metode System Usability Scale (SUS) terhadap 37 responden didapatkan hasil rata-rata skor SUS sebesar 71,261 dengan kategori Acceptable, rating Good, dan grade scale “C” yang dapat diartikan bahwa sistem ini telah diterima serta layak digunakan.
Sentiment Analysis on Social Media Using Word2Vec and Gated Recurrent Unit (GRU) with Genetic Algorithm Optimization
Authors: Syafa Fahreza  , Setiawan Erwin Budi
Published: September 2024

The evolution of information technology has changed the function of social media from a mere information repository to a platform for expressing opinions and aspirations. One of the most used social media is Twitter. Twitter users can express opinions according to their conscience. Therefore, a sentiment analysis process is needed to classify the opinion as positive or negative. Sentiment analysis on social media is important to understand user opinions, monitor public perception, measure campaign performance, identify trends and opportunities, and improve customer service. This research builds a model to perform sentiment analysis on the topic the president election with a total dataset of 39,791 with GRU method, TF-IDF feature extraction, Word2Vec feature expansion with 142,545 corpus from IndoNews, and Genetic Algorithm optimization. The test results show that the highest accuracy achieved is 83.39%, which shows an improvement of 1.42% compared to the baseline. This performance was achieved when combining of TF-IDF with a 5,000 maximum features, applying Word2Vec at top 1 similarity, and applying Genetic Algorithm for feature optimization. This study proves the relationship between the use of Word2Vec feature expansion and Genetic Algorithms as optimization in improving the accuracy of the model created.
Web-based Application for Diagnosis of Diabetes using Learning Vector Quantization (LVQ)
Authors: Puspita Juni Wijayanti , Yanto Kevin Jieventius , Pettalolo Andi Moh. Ridho , Dg. Matona Moh. Ali Akbar , Lilies Handayani
Published: September 2024

Diabetes is a chronic disease that causes the most deaths in the world. This disease can cause long-term complications that develop gradually, such as heart attacks, strokes, and problems with the kidneys, eyes, skin, and blood vessels. Therefore, early diagnosis of diabetes is crucial for patients to know their diabetes status. In this study, we designed a web-based application for diabetes diagnosis using Learning Vector Quantization (LVQ). The dataset was collected from Kaggle's Diabetes Dataset which contains eight attributes, namely pregnancy, glucose, blood pressure, insulin, skin thickness, BMI, diabetes lineage function, and age, with two classes, namely negative diabetes (healthy) and positive diabetes. The results show that the best accuracy is 73.1% with a learning rate of 0.001. These findings can help patients detect diabetes problems early.
Characterizing Future Authoritarian Governance in the Space Domain
Authors: Waller Julian G.
Published: September 2024

Traditionally, discussions of governance beyond Earth have largely been held to the purview of debates about space law and global governance regimes. Yet, the priority of space exploration among ambitious, tech-industry associated billionaires and its continued potential for militarization suggest that a more dynamic approach may be needed, given that state-sponsorship of extraterrestrial colonial projects may be more akin to partnerships between private and public actors rather than nation-states assuming traditional roles as sole sources of decision-making. Permanent settlements in space will require forms of localized government that may look distinct from contemporary models of political order. This article thus asks a provocative question associated with the empirical record of human colonization and settlement in prior eras: What sort of authoritarian governance is most likely to form in human space settlements during the medium term? Reviewing variations on political order in small-scale colonial settlements in light of recent conceptual work on authoritarian rule, the article identifies three theoretical models of governance that may emerge once beyond Earth settlements become permanent fixtures of human society.
Organic Philosophy in the Criticism of A.A. Grigoriev, Philosophy of N.N. Strakhov and Novels of F.M. Dostoevsky
Authors:   Institute of Russian Literature (Pushkin House), Russian Academy of Sciences, Barsht Konstantin
Published: September 2024

The article proposes a hypothesis that the “age-old question” about the meaning and purpose of human life, posed by F.M. Dostoevsky in his youth in a letter to his brother Mikhail, as a program for his entire future life, was solved in the form of a “soil-based” concept, the basis of which was the “organic criti­cism” of A.A. Grigoriev and “organic philosophy” of N.N. Strakhov. This ideological complex was formed under the influence of a number of European philosophers, of which the most important were the works of T. Carlyle, as well as the “senior Slavophiles” A.S. Khomyakov and I.V. Kireyevsky. The literary and aesthetic aspect of the concept was realized in A.A. Grigoriev’s “organic criticism”, the socio-cultural aspect became the basis of the ideological platform of the magazines “Time” and “Epoch” (1861–1865), its formal logical justifica­tion was carried out in the works of N.N. Strakhov. Through the efforts of a cir­cle of thinkers grouped around the editorial offices of the magazines “Time” and “Epoch”, long before N.O. Lossky and A. Bergson, the basic points of philo­sophical intuitionism were developed and analyzed on a variety of thematic material. The article puts forward a version that the ideological basis of the “big” novels by F.M. Dostoevsky (1866–1880) – “Crime and Punishment” (1866), “Idiot” (1868), “Demons” (1872), “Teenager” (1875) and “Brothers Karamazov” (1880) is “organic philosophy”, the main elements of which are reflected at all levels of the artistic structure of the writer’s work
Quining Diet Qualia Part II
Authors:   University of Crete, Heraklion, Frankish Keith , Gorbachev Maxim ,   National Research University Higher School of Economics
Published: September 2024

This is the second part of the article by Keith Frankish Quining Diet Qualia, which asks whether we can identify a neutral explanandum for theories of phe­nomenal consciousness, acceptable to all sides. The “classic” conception of qualia, on which qualia are intrinsic, ineffable, and subjective, will not serve this pur­pose, but it is widely assumed that a watered-down “diet” conception will. I ar­gue that this is wrong and that the diet notion of qualia has no distinctive con­tent. There is no phenomenal residue left when qualia are stripped of their intrinsicality, ineffability, and subjectivity. Thus, if we reject classic qualia real­ism, we should accept that all that needs explaining are “zero” qualia – our dis­positions to judge that our experiences have classic qualia. Diet qualia should, in Dennett’s phrase, be quined
Culture – Sign – Meaning: on the Nature and the Structure of Culture and of Sign
Authors:   Foundation for Humanities, Shiyan Taras
Published: September 2024

The article examines the concept of culture as a paradigmatic structure that defines the variety of possible forms of social life, activity, and behavior in a certain community. It examines the structure and nature of the sign and its place in culture. The author sets this concept of culture and ideas about the structure of the sign, starting from some of F. Saussure’s ideas. He accepts Saussure’s distinction between language and speech within “linguistic activity”, but in the language itself he also distinguishes two areas of existence: language as a paradigmatic structure of a single subject and language as a paradigmatic system existing at the community level. As a result, the author sees not two, but three areas of manifestation in “language activity”. He identifies similar three areas in any semiotic activity and in activity in general. At the same time, in the course of generalization in the series “linguistic activity – sign activity – activity”, the social paradigmatic aspect of these activities is also generalized from language to the sign system and culture as a whole. Since language in public form, and language in individual form, and speech have the word as a basic structural unit, then we can talk about three ontological forms (modi) of the word: in public language, in individual language, in speech. The author identifies similar three ontological modi for an arbitrary sign. Taking as a basis the binary structure of an abstract sign (the plan of expression and the plan of content associated with each other) and the idea of the three ontological modi of the sign, we obtain a triangular prism as an ontological scheme of the sign, where the nodes of the prism correspond to various aspects of the sign, three vertical edges – three ontological modi of the sign, the upper face – the plan of expression (syntax), the bottom face – the plan of content (semantics). Based on the obtained ontological scheme of the sign, the author interprets the semiotic representations of some alternative research programs
RETRACTED: Evaluation of Central Sensitization and Presence of Neuropathic Pain in Patients with Rheumatoid Arthritis and Its Relationship with Quality of Life
Authors: Güngör Zeynep Karakuzu , Güngör Erdal
Published: September 2024

The authors have requested that this preprint be removed from Research Square.
Deforestation and human development in the Brazilian tropical dry forest
Authors: Alencar Lucas , Parry Luke , Melo Felipe
Published: September 2024

The relationship between deforestation and human development is contested in Latin America and may vary between biomes. We evaluated the boom-bust hypothesis across agricultural frontiers in the Brazilian Caatinga dry forest, using panel data (1991-2000-2010) and cross-sectional data (2010) from 1207 municipalities. Municipalities in the advanced deforestation stage (> 66% forest cover lost) had the best development outcomes in 1991 yet by 2010 no indicators were superior to those of intermediate (33 > 66%) and initial stages (< 33%). Initial stage municipalities showed least improvement in development metrics across time, whereas progress was quicker within intermediate frontier stages. Relative improvements in longevity, poverty alleviation, income inequality, and child mortality did not result in a “bust”, but instead, progress stagnated in advanced stage municipalities. Our cross-sectional analysis used a quasi-experimental approach and control for spatial autocorrelation and revealed a relative boom-bust in five of six development indicators. Overall, we find strong evidence that exploitation of natural resources is insufficient for achieving sustained development progress.
Identification of immune-related hub genes and potential molecular mechanisms involved in COVID-19 via integrated bioinformatics analysis
Authors: Zhu Rui , Zhao Yaping , Yin Hui , Shu Linfeng , Ma Yuhang , Tao Yingli
Published: September 2024

Background:COVID-19, caused by the SARS-CoV-2 virus, poses significant health challenges worldwide, particularly due to severe immune-related complications. Understanding the molecular mechanisms and identifying key immune-related genes (IRGs) involved in COVID-19 pathogenesis are critical for developing effective therapeutic strategies.
Methods: This study integrated bioinformatics approaches and Mendelian randomization (MR) analysis to elucidate the roles of IRGs in COVID-19. Differentially expressed genes (DEGs) were identified from GEO datasets comparing COVID-19 patients and healthy controls. IRGs were obtained from the ImmPort database. Functional enrichment, pathway analysis, and immune infiltration assessments were subsequently conducted to determine the biological significance of the identified IRGs.
Results: A total of 360 common differential IRGs were identified. Among these genes, CD1C, IL1B, and SLP1 have emerged as key genes with potential protective effects againstCOVID-19. Pathway enrichment analysis revealed that CD1C is involved in terpenoid backbone biosynthesis and Th17 cell differentiation, while IL1B was linked to B-cell receptor signaling and the NF-kappa B signaling pathway. Significant correlations were observed between key genes and various immune cells, suggesting their influence on immune cell modulation in COVID-19.
Conclusions: This study provides new insights into the immune mechanisms underlying COVID-19, highlighting the crucial role of IRGs in disease progression. These findings suggest that CD1C and IL1B could serve as potential therapeutic targets. The integrated bioinformatics and MR analysis approach offers a robust framework for further exploration of immune responses in patients with COVID-19 and the development of targeted therapies.
Frequency and pattern of patients with Dextro transposition of great arteries undergoing computed tomography angiography in Pakistan and Iran: an international comparative study
Authors: AKHTAR Parveen , TEBHA Sameer Saleem , KHAN NaveedUllah , SIDDIQUI Hasan Fareed , KHAN Fahad , SATTAR Abdul
Published: September 2024

BACKGROUNDː Transposition of the Great Arteries (TGA) is one of the most common types of congenital heart defects (CHD). Recent advances in computed tomography angiography (CTA) have helped in the detection of this condition. However, the scientific literature remains scarce with regards to a comparison between Iran and Pakistan, hence this study was conducted.
METHODSː A cross-sectional study was conducted comparing patient cohorts from Pakistan and Iran. Patients diagnosed with CHD as confirmed by CTA, aged less than 18-year-old were included in this study. Data regarding demographics, nationality, and any CHDs was extracted via patient interviews which were further supplemented by screening of the hospital records. Data analysis was conducted using SPSS version 21 (Chicago, IL: IBM SPSS Statistics) where a p-value <0.05 was statistically significant.
RESULTSː Levocardia was the most common cardiac axis in both of our populations (n=119, 70.0% for Pakistan and n=31, 100.0% for Iran). Ventricular septal defect (VSD) was noted in 154 (90.6%) and 15 (48.4%) of the patients from the Pakistani and Iranian cohort, respectively. Prevalence of patent ductus arteriosus (PDA) was found to be significantly associated between the populations with an increased odds of PDA observed in the Iranian population (n=27, 87.1%) compared to the Pakistani population (n=92, 54.1%) (p <0.001).
CONCLUSIONSː Our study highlights an important association of PDA between Pakistan and Iran, with increased odds of PDA in the Iranian population. Moreover, the prevalence of various CHDs in both populations raises concerns that warrant investigation to study the possible contributory factors.
A case of refractory nasal dermatomyositis-like disease in an adult Poodle
Authors: Oh Songju , Jang Geunhwan , Cho Seung-Bum , Kim Suyeon , Han Jungwoo , Kim Ha-Jung
Published: September 2024

1. Background
Canine inflammatory myopathy (IM) is a disease characterized by nonsuppurative cellular infiltration of the skeletal muscle. Dermatomyositis is primarily observed in Collies, Sheepdogs, and their crossbreeds. However, it also appears sporadically in other species. "Dermatomyositis-like disease" is the term used in such cases. Dermatomyositis-like disease has been occasionally described in other breeds, but it has never been reported in Poodles. Additionally, cases in adult dogs have not been reported. This report outlines the successful management of a case involving an adult small breed dog with dermatomyositis-like disease through the use of immunosuppressive drugs and supportive medications.
2. Case presentation
A 10-year-old spayed female Toy Poodle dog presented with nasal edema, erythema, pain, pruritus, and discharge. The size oflesion had gradually increased, measuring 29×22.8×17.8 mm at the first visit. No infection was detected on microscopic cytologic evaluation of the nasal discharge. On radiography and computed tomography (CT), the nasal septum structure was normal, and bony invasion was not identified. On rhinoscopy, the soft tissues were thickened and erythematous. Decreased lumen diameter and severe congestion were found in the right nasal cavity. On histological examination, there was multifocal-to-coalescing moderate-to-severe inflammation and fibrosis in the deep dermis and skeletal muscle layer. The inflammatory cells were primarily lymphocytes and plasma cells.
3. Conclusions
Based on the patient history and test results, the patient was diagnosed with canine dermatomyositis. Treatment included immunosuppressive agents (prednisolone, cyclosporine) and antibiotics (amoxicillin/clavulanate). This treatment reduced the nasal edema, nasal erythema, and size of lesion. The patient’s clinical signs improved after treatment, and the dog demonstrated clinical benefits at a follow-up visit at 17 weeks. Although canine dermatomyositis usually develops before six months of age, this report demonstrates that this disease can also occur in adult dogs.
Eucommia ulmoides Oliver polysaccharide stimulates bone formation by improving osteoblast differentiation via ERK/BMP-2/SMAD signaling
Authors: Song Jiyu , Zhang Yongfeng , Jin Xinghui , Zhu Yanfeng , Hu Min , Li Yutong
Published: September 2024

Osteoporosis (OP) is a metabolic disease characterized by low bone mineral mass owing to osteoblast dysfunction. Eucommia ulmoides Oliver (EuO) is a Chinese herbal medicine traditionally used to treat OP. Here, a polysaccharide purified from the EuO cortex (EuOCP3) was administered to OP mice constructed with dexamethasone (Dex) to investigate its anti-OP activity. EuOCP3 significantly improved Dex-induced bone microarchitecture destruction, increased osteoblast numbers and surface, and stimulated an increase in the expression of osteoblast differentiation markers in the femurs of OP mice. Furthermore, EuOCP3 was applied to MC3T3-E1 cells to further explore its effects on osteoblast differentiation. EuOCP3 significantly promoted osteoblast differentiation and increased the level of phosphorylated extracellular signal-regulated kinase1/2 (ERK1/2) and SMAD1/5/8 without influencing cell proliferation. The EuOCP3-mediated enhancement of osteoblast differentiation-related proteins and phosphorylated SMAD1/5/8 expression levels was strongly suppressed by an ERK inhibitor (PD98059), which confirmed the critical role of ERK signaling in EuOCP3-induced osteoblast differentiation. In summary, EuOCP3 can stimulate bone formation by improving osteoblast differentiation via ERK/BMP-2/SMAD signaling, indicating the potential use of EuOCP3 as a functional ingredient in food products for anti-OP treatment.
Device Response Principles and the Impact on Energy Resolution of Epitaxial Quantum Dot Scintillators with Monolithic Photodetector Integration
Authors: Minns Allan , Mahajan Tushar , Tokranov Vadim , Yakimov Michael , Oktyabrsky Serge , Hedges Michael , Murat Pavel
Published: September 2024

To meet detector performance benchmarks set for medical imaging, high energy physics and national security applications, scintillator materials with picosecond-scale timing and high light yield have been created. These epitaxially grown GaAs crystals contain InAs quantum dots (QDs) forming a semiconductor heterostructure which emits light at wavelengths where GaAs is transparent. Total internal reflection (TIR) provides a cladding effect and monolithic photodetector (PD) integration enables efficient light collection. Previously, we reported on devices with complex, high variance responses to monoenergetic sources. The origin of these responses is now elucidated and utilized to achieve material-related energy resolution values of 2.4% with alpha particles. These findings place energy resolution alongside luminescence timescale, photon yield, and radiation hardness as favorable properties of these engineered materials.
Association between sarcopenia and constipation in patients with dysphagia: A cross-sectional study
Authors: Kishima Masako , Wakabayashi Hidetaka , Itoda Masataka , Hachiuma Chiro , Nishioka Shinta , Momosaki Ryo
Published: September 2024

Purpose We investigated the relationship between sarcopenia and constipation at multiple facilities in Japan.
Method This cross-sectional study used data from the Japanese Sarcopenic Dysphagia Database. The 19 hospitals included nine acute care hospitals, eight rehabilitation hospitals, two long-term care hospitals, and one home-visiting rehabilitation center. The participants were 460 patients aged 20 years with swallowing disorders. Sarcopenia was diagnosed by the 2019 Asian Working Group for Sarcopenia criteria. Constipation was diagnosed based on the definition of the Japanese Chronic Constipation Treatment Guidelines. We investigated whether there was a significant difference in the prevalence of constipation between patients with and without sarcopenia. Logistic regression analysis was performed to examine the association between sarcopenia and constipation after adjusting for age, sex, facility, CCI, and enteral nutrition.
Results The participants were composed of 229 males (50%) and 231 females (50%), with a mean age of 81 ± 10 years. Of the 460 patients, 404 (88%) had sarcopenia, and 72 (16%) had constipation. The logistic regression analysis revealed no significant association between sarcopenia and constipation (odds ratio: 1.279, 95% confidence interval: 0.492, 3.324). Factors associated with constipation were facility-specific (odds ratio: 3.695, 95% confidence interval: 1.955, 6.983). The prevalence of constipation in rehabilitation hospitals and long-term care hospitals was 20% and 26%, respectively.
Conclusions The prevalence of constipation in patients with sarcopenia was 16%. There was no statistically significant association between sarcopenia and constipation.
Building A Modern Data Platform Based On The Data Lakehouse Architecture And Cloud-Native Ecosystem
Authors: AbouZaid Ahmed , Barclay Peter J. , Chrysoulas Christos , Pitropakis Nikolaos
Published: September 2024

In today’s Big Data world, organisations can gain a competitive edge by adopting data-driven decision-making. However, a modern data platform that is portable, resilient, and efficient is required to manage organisations’ data and support their growth. Furthermore, the change in the data management architectures was accompanied by changes in storage formats, particularly open standard formats like Apache Hudi, Apache Iceberg, and Delta Lake. With many alternatives, organisations are unclear on how to combine these into an effective platform. Our work investigates capabilities provided by Kubernetes and other Cloud-Native software, using DataOps methodologies to build a generic data platform that follows the Data Lakehouse architecture. We define the data platform specification, architecture, and core components to build a proof of concept system. Moreover, we provide a clear implementation methodology by developing the core of the proposed platform, which are infrastructure (Kubernetes), ingestion and transport (Argo Workflows), storage (MinIO), and finally, query and processing (Dremio). We then conducted performance benchmarks using an industry-standard benchmark suite to compare cold/warm start scenarios and assess Dremio’s caching capabilities, demonstrating a 33% median enhancement of query duration with caching.