bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary Recurrence in the Lung is Related to Favorable Prognosis in Patients with Pancreatic Cancer and Postoperative Recurrence
Authors: Zheng Biao , Ohuchida Kenoki , Yan Zilong , Okumura Takashi , Ohtsuka Takao , Nakamura Masafumi
Published: June 2017

Background

The pattern of recurrence affects the clinical outcome in tumor patients. However, the clinical significance of lung metastasis as the primary recurrence site after resection in patients with pancreatic cancer remains unclear. This study aimed to clarify the clinical significance of the primary recurrence site in patients with pancreatic cancer, in terms of prognosis and clinicopathological features.

Methods

This retrospective cohort study included 220 patients with postoperative recurrence after pancreatectomy for pancreatic cancer and classified by primary site of recurrence. We focused on patients with lung metastasis as the primary recurrence and investigated its correlation with prognosis and clinicopathological factors.

Results

Twenty‐four (11%) patients had lung metastasis as the primary recurrence. This recurrence pattern had the best prognosis among all recurrence patterns, including liver metastasis and local recurrence. Patients with lung metastasis as the primary recurrence had favorable overall survival and survival from the date of recurrence compared with patients with other primary recurrence sites in both univariate (P = 0.0008 and P = 0.0005) and multivariate analyses (P = 0.0051 and P = 0.0068). In terms of clinicopathological features of resected pancreatic tumors, lung metastasis as the primary recurrence was associated with lower tumor stage and histologic grade, and less vascular invasion and residual tumor volume than liver metastasis.

Conclusions

Pancreatic cancer patients with lung metastasis as the primary recurrence after pancreatectomy have a better prognosis than those with other recurrence patterns.
Outcomes of Kidney Donors over 60 Years Old: A Single‐Center Cohort Study
Authors: Gero Daniel , Dib Fadia , Matter Maurice , Pascual Manuel , Venetz Jean‐Pierre , Demartines Nicolas , Melloul Emmanuel
Published: June 2017

Aim

To evaluate outcomes and post‐donation kidney function of older living kidney donors (LKD).

Methods

Retrospective analysis of prospective database including all consecutive LKD undergoing laparoscopic nephrectomy in a single center (09/1998‐12/2013). LKD aged ≥60 years were compared to younger LKD. Renal function assessed by creatinine levels and estimated glomerular filtration rates (eGFR). Surgical complications classified according to the Clavien–Dindo classification. Bivariate and multivariate analyses using linear mixed effect models were performed to determine factors (age, gender, hypertension status, BMI, choice of better functioning kidney for donation) that might impinge on renal function after donation.

Results

213 LKD were identified: 49 older (median age: 66 years, range: 60–79) and 164 younger (median age: 46, range: 25–59). Mean operative time (149 vs. 152 min, p = 0.69), conversion to laparotomy (n = 1 vs. 3, p = 0.92), grade III–IV complications (n = 4 vs. 2, p = 0.36) were similar. Older had more grade I–II complications (n = 18 vs. 4, p < 0.001). Despite similar pre‐donation eGFR (80 vs. 84 ml/min/1.73 m2), older donors presented significantly lower eGFR during inpatient period (46 vs. 51 ml/min/1.73 m2, p = 0.0003), at 1 month (51 vs. 58 ml/min/1.73 m2, p = 0.002) and at 1 year (54 vs. 62 ml/min/1.73 m2, p = 0.001). Multivariate analysis adjusted to gender, hypertension status, BMI and choice of better functioning kidney for donation showed that at 1 year, age ≥60 affected renal function by a coefficient of 0.91 (p < 0.001).

Conclusion

Despite renal function improvement after discharge, LKD ≥ 60 years presented lower eGFR than younger at one year and had more grade I–II surgical complications.
Evaluation of Open and Minimally Invasive Adrenalectomy: A Systematic Review and Network Meta‐analysis
Authors: Heger Patrick , Probst Pascal , Hüttner Felix J. , Gooßen Käthe , Proctor Tanja , Müller‐Stich Beat P. , Strobel Oliver , Büchler Markus W. , Diener Markus K.
Published: June 2017

Background

Adrenalectomy can be performed via open and various minimally invasive approaches. The aim of this systematic review was to summarize the current evidence on surgical techniques of adrenalectomy.

Methods

Systematic literature searches (MEDLINE, EMBASE, Web of Science, Cochrane Library) were conducted to identify randomized controlled trials (RCTs) and controlled clinical trials (CCTs) comparing at least two surgical procedures for adrenalectomy. Statistical analyses were performed, and meta‐analyses were conducted. Furthermore, an indirect comparison of RCTs and a network meta‐analysis of CCTs were carried out for each outcome.

Results

Twenty‐six trials (1710 patients) were included. Postoperative complication rates did not show differences for open and minimally invasive techniques. Operation time was significantly shorter for open adrenalectomy than for the robotic approach (p < 0.001). No differences were found between laparoscopic and robotic approaches. Network meta‐analysis showed open adrenalectomy to be the fastest technique. Blood loss was significantly reduced in the robotic arm compared with open and laparoscopic adrenalectomy (p = 0.01). Length of hospital stay (LOS) was significantly lower after conventional laparoscopy than open adrenalectomy in CCTs (p < 0.001). Furthermore, both retroperitoneoscopic (p < 0.001) and robotic access (p < 0.001) led to another significant reduction of LOS compared with conventional laparoscopy. This difference was not consistent in RCTs. Network meta‐analysis revealed the lowest LOS after retroperitoneoscopic adrenalectomy.

Conclusion

Minimally invasive adrenalectomy is safe and should be preferred over open adrenalectomy due to shorter LOS, lower blood loss, and equivalent complication rates. The retroperitoneoscopic access features the shortest LOS and operating time. Further high‐quality RCTs are warranted, especially to compare the posterior retroperitoneoscopic and the transperitoneal robotic approach.
-stability of expanding maps in non-Archimedean dynamics
Authors: LEE JUNGHUN
Published: June 2017

The aim of this paper is to show $J$-stability of expanding rational maps over an algebraically closed, complete and non-Archimedean field of characteristic zero. More precisely, we will show that for any expanding rational map, there exists a neighborhood of it such that the dynamics on the Julia set of any rational map in the neighborhood is the same as the dynamics of the expanding rational map as a non-Archimedean analogue of a corollary of Mañé, Sad and Sullivan’s result [On the dynamics of rational maps. Ann. Sci. Éc. Norm. Supér. (4)16 (1983), 193–217] in complex dynamics.
Submesoscale surface fronts and filaments: secondary circulation, buoyancy flux, and frontogenesis
Authors: McWilliams James C.
Published: June 2017

Problems are posed and solved for upper-ocean submesoscale density fronts and filaments in the presence of surface wind stress and the associated boundary-layer turbulent mixing, their associated geostrophic and secondary circulations and their instantaneous buoyancy fluxes and frontogenetic evolutionary tendencies in both velocity and buoyancy gradients. The analysis is diagnostic rather than prognostic, and it is based on a momentum-balanced approximation that assumes the ageostrophic acceleration is negligible, although the Rossby number is finite and ageostrophic advection is included, justified by the quasi-steady, coherent-structure flow configurations of fronts and filaments. Across a wide range of wind and buoyancy-gradient parameters, the ageostrophic secondary circulation for a front is a single overturning cell with downwelling on the dense side, hence with a positive (restratifying) vertical buoyancy flux. For a dense filament the circulation is a double cell with central downwelling and again positive vertical buoyancy flux. The primary explanation for these secondary-circulation cells is a ‘turbulent thermal wind’ linear momentum balance. These circulation patterns, and their associated frontogenetic tendencies in both the velocity and buoyancy gradients, are qualitatively similar to those due to the ‘classical’ mechanism of strain-induced frontogenesis. For linear solutions, the secondary circulation and frontogenesis are essentially independent of wind direction, but in nonlinear solutions ageostrophic advection provides a strong intensification of the peak vertical velocity, while generally preserving the ageostrophic circulation pattern, when the Rossby number is order one and the wind orientation relative to the frontal axis is favourable. At large Rossby number the solution procedure fails to converge, with an implication of a failure of existence of wholly balanced circulations.
Outbreak of non-tuberculous mycobacteria skin or soft tissue infections associated with handling fish – New York City, 2013–2014
Authors: YACISIN K. , HSIEH J. L. , WEISS D. , ACKELSBERG J. , LEE E. , JONES L. , LEUNG Y. L. , LI L. , YUNG J. , SLAVINSKI S. , HANSON H. , RIDPATH A. , KORNBLUM J. , LIN Y. , ROBBE-AUSTERMAN S. , RAKEMAN J. , SIEMETZKI-KAPOOR U. , STUBER T. , GREENE S. K.
Published: June 2017

Mycobacterium marinum, a bacterium found in freshwater and saltwater, can infect persons with direct exposure to fish or aquariums. During December 2013, the New York City Department of Health and Mental Hygiene learned of four suspected or confirmed M. marinum skin or soft tissue infections (SSTIs) among persons who purchased whole fish from Chinese markets. Ninety-eight case-patients with non-tuberculous mycobacteria (NTM) SSTIs were identified with onset June 2013–March 2014. Of these, 77 (79%) were female. The median age was 62 years (range 30–91). Whole genome sequencing of clinical isolates revealed two main clusters and marked genetic diversity. Environmental samples from distributors yielded NTM though not M. marinum. We compared 56 case-patients with 185 control subjects who shopped in Chinese markets, frequency-matched by age group and sex. Risk factors for infection included skin injury to the finger or hand (odds ratio [OR]: 15·5; 95% confidence interval [CI]: 6·9–37·3), hand injury while preparing fish or seafood (OR 8·3; 95% CI 3·8–19·1), and purchasing tilapia (OR 3·6; 95% CI 1·1–13·9) or whiting (OR 2·7; 95% CI 1·1–6·6). A definitive environmental outbreak source was not identified.
The journey to autism: Insights from neuroimaging studies of infants and toddlers
Authors: Wolff Jason J. , Jacob Suma , Elison Jed T.
Published: June 2017

By definition, autism spectrum disorder (ASD) is a neurodevelopmental disorder that emerges during early childhood. It is during this time that infants and toddlers transition from appearing typical across multiple domains to exhibiting the behavioral phenotype of ASD. Neuroimaging studies focused on this period of development have provided crucial knowledge pertaining to this process, including possible mechanisms underlying pathogenesis of the disorder and offering the possibility of prodromal or presymptomatic prediction of risk. In this paper, we review findings from structural and functional brain imaging studies of ASD focused on the first years of life and discuss implications for next steps in research and clinical applications.
A case of intracardiac echinococcosis
Authors: Kara Soner Sertan , Gullu Ufuk Utku
Published: June 2017

We describe a case of multisystemic cystic echinococcosis exhibiting intracardiac involvement. A lesion inside the lateral wall of the left ventricle induced negative T waves on leads V5 and V6.
Clinical characterization of Italian suicide attempters with bipolar disorder
Authors: Dell’Osso Bernardo , Vismara Matteo , Dobrea Cristina , Cremaschi Laura , Grancini Benedetta , Arici Chiara , Benatti Beatrice , Buoli Massimiliano , Ketter Terence A. , Altamura A. Carlo
Published: June 2017

Introduction

Bipolar disorder (BD) is a chronic, highly disabling condition associated with psychiatric/medical comorbidity and substantive morbidity, mortality, and suicide risks. In prior reports, varying parameters have been associated with suicide risk.

Objectives

To evaluate sociodemographic and clinical variables characterizing Italian individuals with BD with versus without prior suicide attempt (PSA).

Methods

A sample of 362 Italian patients categorized as BD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM IV-TR) was assessed and divided in 2 subgroups: with and without PSA. Sociodemographic and clinical variables were compared between prior attempters and non-attempters using corrected multivariate analysis of variance (MANOVA).

Results

More than one-fourth of BD patients (26.2%) had a PSA, with approximately one-third (31%) of these having>1 PSA. Depressive polarity at onset, higher number of psychiatric hospitalizations, comorbid alcohol abuse, comorbid eating disorders, and psychiatric poly-comorbidity were significantly more frequent (p<.05) in patients with versus without PSA. Additionally, treatment with lithium, polypharmacotherapy (≥4 current drugs) and previous psychosocial rehabilitation were significantly more often present in patients with versus without PSA.

Conclusions

We found several clinical variables associated with PSA in BD patients. Even though these retrospective findings did not address causality, they could be clinically relevant to better understanding suicidal behavior in BD and adopting proper strategies to prevent suicide in higher risk patients.
Learning and Memory in Adolescents With Critical Biventricular Congenital Heart Disease
Authors: Cassidy Adam R. , Newburger Jane W. , Bellinger David C.
Published: June 2017

Objectives: Although evidence exists of broadly defined memory impairment among adolescents with critical congenital heart disease (CHD), nuanced investigations of declarative memory in this at-risk population have not been conducted. This study had two primary aims: (1) to conduct a fine-grained analysis of a range of relevant learning and memory processes in adolescents with critical biventricular CHD, and (2) to identify risk, odds, and predictors of memory impairment. Methods: Data were combined from two single-center studies of neurodevelopmental outcomes in critical CHD. Two-hundred seven adolescents (Mage=15.61±1.0 years) with critical CHD (139 with dextro-transposition of the great arteries and 68 with tetralogy of Fallot without an identified genetic condition), as well as 61 healthy referents (Mage=15.27±1.1 years) completed a neuropsychological evaluation which included the Children’s Memory Scale. Results: Whereas visual-spatial memory deficits were found in both CHD subgroups, verbal memory abilities were relatively preserved. Adolescents with CHD demonstrated stronger memory for Stories than Word Pairs, t (203)=2.63, p=.009, and for Dot Locations than Faces, t(204)=−2.57, p=.01. CHD subgroup, socioeconomic status, sex, and seizure history were among the most frequent significant predictors of memory impairment. Seizure history, in particular, was associated with a 2 to 3 times greater odds of impaired performance on learning and memory tasks. Conclusions: Adolescents with critical biventricular CHD are at risk for deficits in aspects of declarative memory. Independent risk factors for worse outcome include history of seizures. (JINS, 2017, 23, 627–639)
Economy as instituted process: the case of hard rock mining in the United States
Authors: BROWN CHRISTOPHER
Published: June 2017

I examine the origin and development of institutions that assign and enforce rights to hard rock minerals located on federal lands in the United States. Hard rock mining gives a prime example of the ‘artificial selection’ of settled customs or working rules by jurists and legislators. The evolving structure of the industry, conditioned by technological and market factors, produced a parallel shift in the locus and control ofsovereignty.In the early days sovereignty vested in the mining clubs. The enlarging scale and complexity of mining catalysed a change in both the uses and location of sovereignty. With the transition from prospecting to large-scale industrial mining, the ‘right to use’ mineral deposits obtained through patents became contingent on the cooperation of labour. At this stage, the capture of the state's monopoly on legitimate violence to protect the right to use became a crucial dimension of property. Mining companies have also enjoyed liberties with respect to the externalization of environmental costs. The emergent structure of rights, duties, capacities and exposures was instrumental in bringing forth a quantum increase in the mining of hard rock minerals necessary for industrial expansion. There is, however, an urgent need for reform of the mineral patent system.
Erratum: Ruthenium-cobalt nanoalloys encapsulated in nitrogen-doped graphene as active electrocatalysts for producing hydrogen in alkaline media
Authors: Su Jianwei , Yang Yang , Xia Guoliang , Chen Jitang , Jiang Peng , Chen Qianwang
Published: June 2017

Nature Communications 8: Article number: 14969 (2017); Published: 25 April 2017; Updated: 20 June 2017 In the original version of this Article, which was received on 04 November 2016, the received date was incorrectly given as 04 November 2017. This has now been corrected in both the PDF and HTML versions of the Article.
Silicon amendment is involved in the induction of plant defense responses to a phloem feeder
Authors: Yang Lang , Han Yongqiang , Li Pei , Li Fei , Ali Shahbaz , Hou Maolin
Published: June 2017

Plant resistance to herbivores is a key component in integrated pest management. In most cases, silicon (Si) amendment to plants enhances resistance to herbivorous insects. The increase of plant physical barrier and altered insect behaviors are proposed as mechanisms for the enhanced resistance in Si-amended plants, but our understanding of the induced mechanisms involved in Si-enhanced plant resistance to phloem-feeding insects remains unclear. Here, we show that Si amendment to rice (Oryza sativa) plants impacts multiple plant defense responses induced by a phloem-feeder, the brown planthopper (Nilaparvata lugens, BPH). Si amendment improved silicification of leaf sheaths that BPH feed on. Si addition suppressed the increase of malondialdehyde concentration while encouraged increase of H2O2concentration in plants attacked by BPH. Higher activities of catalase and superoxide dismutase were recorded in Si-amended than in non-amended BPH-infested plants. BPH infestation activated synthases for secondary metabolites, polyphenol oxidase and pheny-lalanine ammonia-lyase, and β-1,3-glucanase, but the activation was greater in Si-amended than in non-amended plants. Taken together, our findings demonstrate that Si amendment interacts with BPH infestation in the induction of plant defense responses and consequently, to confer enhanced rice plant resistance.
A novel stress response mechanism, triggered by indole, involved in quorum quenching enzyme MomL and iron-sulfur cluster in Muricauda olearia Th120
Authors: Wang Yan , Li Hui , Cui Xinxin , Zhang Xiao-Hua
Published: June 2017

Indole, as a signal molecule, is involved in multiple physiological behavior including biofilm formation, antibiotic resistance and virulence. In this study, we demonstrated that indole was involved in iron deficient and H2O2 stress response in Muricauda olearia Th120. Transcriptome analysis showed that totally 206 genes were regulated by exogenous indole. Besides, momL-suf gene cluster, consisting of quorum quenching enzyme coding gene momL and iron-sulfur biosynthetic genes suf, were involved in indole-induced stress response pathway. The result indicated that indole not only up-regulated momL-suf gene cluster, but also enhanced the MomL secretion and the growth rates of MomL-bearing strains in H2O2 stress and iron deficient culture conditions. Co-incubation of M. olearia Th120 and Pectobacterium carotovorum subsp. carotovorum under H2O2 condition revealed that M. olearia Th120 bearing MomL possessed an increased competitive advantage, whereas its competitor had a reduced survival. The phenomenon that quorum quenching enzyme is triggered by stress factor has been rarely reported. The study also opens a new clue to explore the indole function towards quorum quenching factor in bacteria.
Preparation and evaluation of β-cyclodextrin functionalized periodic mesoporous organosilica open tubular capillary columns
Authors: Guo Dongqiang , Liu Mingxia , Zhong Shangwei , Dong Yalei , Li Xiangjun
Published: June 2017

This study describes the preparation and electrochromatographic application of a chiral β-cyclodextrin functionalized periodic mesoporous organosilica bonded open tubular capillary column.
Monoradical-containing four-coordinate Co(iii) complexes: homolytic S–S and Se–Se bond cleavage and catalytic isocyanate to urea conversion under sunlight
Authors: Paul Ganesh Chandra , Ghorai Samir , Mukherjee Chandan
Published: June 2017

Four-coordinate, Co(iii)-monoradical complexes participated in homolytic S–S/Se–Se bonds scission and catalyzed the conversion of RNCO to the corresponding urea derivatives (TON 480) under sunlight.
Exploiting the dual role of ethynylbenziodoxolones in gold-catalyzed C(sp)–C(sp) cross-coupling reactions
Authors: Banerjee Somsuvra , Patil Nitin T.
Published: June 2017

Reported herein is the gold-catalyzed alkynylation of terminal alkynes using ethynylbenziodoxolones (EBXs), where EBXs serve a dual role as oxidants as well as alkyne transfer agents to access unsymmetrical 1,3-diynes. Hence, the catalytic system requires no external oxidants and is compatible with a broad range of substrates, including those with polar functional groups such as NH, OH and B(OH)2.
Correction: Lanthanide separation using size-selective crystallization of Ln-MOFs
Authors: Ya Gao Heng , Li Peng Wen , Pan Meng Pan , Feng Feng Xue , Qiang Li Jian , Qiong Wu Hui , Sheng Yan Chang , Yang Xiong Yang , Luo Feng
Published: June 2017

Correction for ‘Lanthanide separation using size-selective crystallization of Ln-MOFs’ by Heng Ya Gao et al., Chem. Commun., 2017, DOI: 10.1039/c7cc01898c.
Facile synthesis of self-assemblies of ultrathin round Pd nanosheets or nanorings and their enhanced electrocatalytic activities
Authors: Wang Huan , He Xing , Zhao Yanxi , Li Jinlin , Huang Tao , Liu Hanfan
Published: June 2017

Self-assemblies of ultrathin round Pd nanosheets are fabricated in a facile one-pot process and Pd nanoring self-assemblies are also generated.
An investigation of Na-related defects in Cu2ZnSnSe4
Authors: Han Miaomiao , Zhang Xiaoli , Zeng Zhi
Published: June 2017

In this work, we have investigated the Na-related defect properties and migration mechanisms of Na in Cu2ZnSnSe4.
Solid surface vs. liquid surface: nanoarchitectonics, molecular machines, and DNA origami
Authors: Ariga Katsuhiko , Mori Taizo , Nakanishi Waka , Hill Jonathan P.
Published: June 2017

Comparisons of science and technology between these solid and liquid surfaces would be a good navigation for current-to-future developments.
Cu supported on mesoporous ceria: water gas shift activity at low Cu loadings through metal–support interactions
Authors: Vovchok Dimitriy , Guild Curtis J. , Llorca Jordi , Xu Wenqian , Jafari Tahereh , Toloueinia Panteha , Kriz David , Waluyo Iradwikanari , Palomino Robert M. , Rodriguez José A. , Suib Steven L. , Senanayake Sanjaya D.
Published: June 2017

We synthesized, characterized and tested Cu supported mesoporous CeO2 catalyst for the water-gas shift (WGS) reaction.
Hierarchical self-assembly of photoluminescent CdS nanoparticles into a bile acid derived organogel: morphological and photophysical properties
Authors: Chatterjee Sayantan , Maitra Uday
Published: June 2017

A simple strategy for the preparation of a new bile acid derived organogel–CdS NP hybrid, and the study of its photophysical and morphological properties.
Tuning the solution organization of cationic polymers through interactions with bovine serum albumin
Authors: Papagiannopoulos Aristeidis , Vlassi Eleni , Pispas Stergios , Jafta Charl J.
Published: June 2017

Interactions of BSA with cationic QIm-PCMS aggregates lead to complexes with increased mass, while the BSA secondary structure is critically compromised.
Predictive models of gas sorption in a metal–organic framework with open-metal sites and small pore sizes
Authors: Pham Tony , Forrest Katherine A. , Franz Douglas M. , Guo Zhiyong , Chen Banglin , Space Brian
Published: June 2017

Simulations of gas sorption in UTSA-20 using highly accurate polarizable potentials reproduced experimental observables and provided insights into the binding sites in the material.
Charge-transfer and impulsive electronic-to-vibrational energy conversion in ferricyanide: ultrafast photoelectron and transient infrared studies
Authors: Ojeda José , Arrell Christopher A. , Longetti Luca , Chergui Majed , Helbing Jan
Published: June 2017

The photophysics of ferricyanide in H2O, D2O and ethylene glycol was studied upon excitation of ligand-to-metal charge transfer (LMCT) transitions by combining ultrafast photoelectron spectroscopy (PES) of liquids and transient vibrational spectroscopy.
Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells
Authors: Jackson Joshua M. , Witek Małgorzata A. , Kamande Joyce W. , Soper Steven A.
Published: June 2017

We present a critical review of microfluidic technologies and material effects for the selection of CTCs from the blood of cancer patients. We provide context for device performance using fundamental principles and discuss how microfluidics enables CTC-based molecular profiling to provide information that may affect patient outcome.
A chelating bis(aminophenol) ligand bridged by a 1,1′-ferrocene-bis(para-phenylene) linker
Authors: Swanson Daniel D. , Conner Kyle M. , Brown Seth N.
Published: June 2017

The 1,1′-ferrocene-bis(p-phenylene) group serves as a structural linker connecting two iminosemiquinones to palladium without significant electronic interactions between the ferrocene and the palladium complex.
Multidentate silyl ligands in transition metal chemistry
Authors: Simon M. , Breher F.
Published: June 2017

This review presents and discusses the use of multidentate silanide ligands in transition metal chemistry depending on their ligand architecture.
An environmentally benign double Michael addition reaction of heterocyclic ketene aminals with quinone monoketals for diastereoselective synthesis of highly functionalized morphan derivatives in water
Authors: Ma Yu-Lu , Wang Kai-Min , Huang Rong , Lin Jun , Yan Sheng-Jiao
Published: June 2017

This effort involved an efficient and concise one-pot procedure for the synthesis of morphans based on quinone monoketals 1 reacting with HKAs 2.
Label-free selective detection of ampicillin drug in human urine samples using silver nanoparticles as a colorimetric sensing probe
Authors: Shrivas Kamlesh , Sahu Jharna , Maji Pathik , Sinha Deepak
Published: June 2017

Stable citrate-capped silver nanoparticles (AgNPs) were developed as a colorimetric sensing probe for selective detection of ampicillin in urine samples.
Adsorption of carbon dioxide on TEPA-modified TiO2/titanate composite nanorods
Authors: Kapica-Kozar Joanna , Michalkiewicz Beata , Wrobel Rafal J. , Mozia Sylwia , Piróg Ewa , Kusiak-Nejman Ewelina , Serafin Jarosław , Morawski Antoni W. , Narkiewicz Urszula
Published: June 2017

CO2was successfully chemisorbed/physisorbed on a TiO2/titanate composite nanorod functionalized with TEPA amine.
Two-dimensional honeycomb hafnene monolayer: stability and magnetism by structural transition
Authors: Hashmi Arqum , Umar Farooq M. , Khan Imran , Hong Jisang
Published: June 2017

A few years ago, it was claimed that the two-dimensional ferromagnetic planar Hf monolayer could be synthesized on Ir(111).
High-performance photodetectors based on Sb2S3 nanowires: wavelength dependence and wide temperature range utilization
Authors: Zhong Mianzeng , Wang Xinghua , Liu Sijie , Li Bo , Huang Le , Cui Yu , Li Jingbo , Wei Zhongming
Published: June 2017

High-quality Sb2S3 nanowires are synthesized by a sulphur-assisted vapour transport method, and then utilized in high performance photodetectors which exhibit good photoresponse in a wide spectral range from about 300 to 800 nm, and in a wide temperature range from 8 to 420 K.
Platinated porphyrin as a new organelle and nucleus dual-targeted photosensitizer for photodynamic therapy
Authors: Zhu Sizhe , Yao Si , Wu Fengshou , Jiang Lijun , Wong Ka-Leung , Zhou Ji , Wang Kai
Published: June 2017

Two novel porphyrin compounds Pt-Por-RB and Me-Por-RB were synthesized and characterized. Compared with Me-Por-RB, Pt-Por-RB was internalized not only in organelles, but also in nuclei of HeLa cells, indicating that it is an effective dual-targeted PDT agent.
Synthesis and biological evaluation of N-arylated-lactam-type iminosugars as potential immunosuppressive agents
Authors: Liu Hai-Qian , Song Cheng-Cheng , Niu You-Hong , Li Tao , Li Qin , Ye Xin-Shan
Published: June 2017

NewN-arylated iminosugar derivatives were designed and synthesized, leading to the identification of potent immunosuppressive agents.
Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation
Authors: Balalaie Saeed , Shamakli Mohammad , Nikbakht Ali , Alavijeh Nahid S. , Rominger Frank , Rostamizadeh Shahnaz , Bijanzadeh Hamid Reza
Published: June 2017

A diversity-oriented access to isoxazolino and isoxazolo benzazepines is elaborated via a post-Ugi heteroannulation involving intramolecular 1,3-dipolar cycloaddition reaction of nitrile oxides with alkenes and alkynes.
Environmentally sensitive molecular probes reveal mutations and epigenetic 5-methyl cytosine in human oncogenes
Authors: Taskova M. , Barducci M. C. , Astakhova K.
Published: June 2017

There is currently an unmet need for reliable tools that allow for direct detection and quantification of modifications in genomic DNA.
Iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines: synthesis of quinazolines by trapping of ammonia
Authors: Gopalaiah Kovuru , Saini Anupama , Devi Alka
Published: June 2017

A novel iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines has been developed, which provides a facile access to 2-substituted quinazolines.
A Pd-catalyzed, boron ester-mediated, reductive cross-coupling of two aryl halides to synthesize tricyclic biaryls
Authors: Chen Zhilong , Wang Xiaodong
Published: June 2017

A direct cross-coupling of two different aryl halides in the presence of a palladium catalyst and boron ester was developed to synthesize tricyclic biaryls in one step.
Effect of ligand sequence-specific modification on DNA hybrid catalysis
Authors: Zhou H. , Chen D. , Bai J. K. , Sun X. L. , Li C. , Qiao R. Z.
Published: June 2017

We report a sequence-specific catalytic ligand as a chemical modification strategy to achieve DNA-based asymmetric reactions with sequence-dependent enantioselectivity.
Four-fold increase in epoxide polymerization rate with change of alkyl-substitution on mono-μ-oxo-dialuminum initiators
Authors: Ferrier R. C. , Imbrogno J. , Rodriguez C. G. , Chwatko M. , Meyer P. W. , Lynd N. A.
Published: June 2017

We present an improvement in the rate, utility, and mechanistic understanding of mono-μ-oxo-dialuminum initiators for epoxide ring-opening polymerization.
Synthesis, crystal structures, and electronic properties of one dimensional Ba9Sn3(Te1−xSex)15 (x = 0–1)
Authors: Zhang Jun , Su Rui , Wang Xiancheng , Li Wenmin , Zhao Jianfa , Deng Zheng , Zhang Sijia , Feng Shaomin , Liu Qingqing , Zhao Huaizhou , Guan Pengfei , Jin Changqing
Published: June 2017

The new semiconducting compounds Ba9Sn3(Te1−xSex)15 synthesized under high pressure and high temperature are constructed with trimeric SnTe/Se6 octahedron chains.
Same titanium glycolate precursor but different products: successful synthesis of twinned anatase TiO2 nanocrystals with excellent solar photocatalytic hydrogen evolution capability
Authors: Cheng Gang , Wei Yi , Xiong Jinyan , Gan Yixin , Zhu Jiaxin , Xu Feifan
Published: June 2017

Exploiting a synthesis protocol to tailor TiO2 with a unique morphology and crystal phase has received considerable interest in the energy and environmental fields.
[C5H12N]CdCl3: an ABX3 perovskite-type semiconducting switchable dielectric phase transition material
Authors: Zeb Aurang , Sun Zhihua , Khan Tariq , Asghar Muhammad Adnan , Wu Zhenyue , Li Lina , Ji Chengmin , Luo Junhua
Published: June 2017

We report a new lead-free ABX3 perovskite-type hybrid, which displays high thermal stability, semiconducting and striking switchable dielectric properties.
Synthesis of 2,3-dihydro-1H-phosphindole-1-oxides via the t-BuLi-mediated rearrangement of vinyl bromides and phosphine oxides
Authors: Li Bin , Zhang Mingkai , Huang Xulun , Gu Zhenhua
Published: June 2017

We report an intramolecular vinyllithium addition to phosphine oxides, and discovered an unexpected rearrangement to form unique cyclic phosphine oxides.
Stepwise self-assembly of a block copolymer–platinum(ii) complex hybrid in solvents of variable quality: from worm-like micelles to free-standing sheets to vesicle-like nanostructures
Authors: Liu Nijuan , He Qun , Wang Yongyue , Bu Weifeng
Published: June 2017

Worm-like micelles of a block copolymer–platinum(ii) hybrid evolve into sheet- and vesicle-like nanostructures in solvents of weakened quality. The worm-like micelles snap off to form star micelles or short worms that still hold their core–shell structures.
The sandpile revisited: computer assisted determination of constitutive relations and the breaking of scaling
Authors: Hentschel H. George E. , Jaiswal Prabhat K. , Mondal Chandana , Procaccia Itamar , Zylberg Jacques
Published: June 2017

We revisit the problem of the stress distribution in a frictional sandpile with both normal and tangential (frictional) inter-granular forces, under gravity, equipped with a new numerical method of generating such assemblies.
Highly and homogeneously conductive conjugated polyelectrolyte hole transport layers for efficient organic solar cells
Authors: Xu Haitao , Fu Xiang , Cheng Xiaofang , Huang Liqiang , Zhou Dan , Chen Lie , Chen Yiwang
Published: June 2017

High and homogeneous mobility of PCPDT-T can improve the efficiency and thickness insensitivity of organic solar cells.
LBL assembled polyelectrolyte nanofiltration membranes with tunable surface charges and high permeation by employing a nanosheet sacrificial layer
Authors: Lin Zhen , Zhang Qiugen , Qu Yan , Chen Mengmeng , Soyekwo Faizal , Lin Chenxiao , Zhu Aimei , Liu Qinglin
Published: June 2017

A novel strategy is developed to fabricate LBL assembled polyelectrolyte nanofiltration membranes with tiny filtration resistance and tunable surface charges and thus leading to high permeation flux and excellent rejections for charged molecules.
Electrochemical Na+storage properties of SnO2/graphene anodes in carbonate-based and ionic liquid electrolytes
Authors: Chen Hung-Ching , Patra Jagabandhu , Lee Sheng-Wei , Tseng Chung-Jen , Wu Tzi-Yi , Lin Ming-Hsein , Chang Jeng-Kuei
Published: June 2017

With a proper design of electrolyte composition, high charge–discharge performance and high cyclic stability of sodium-ion battery anodes are achievable.
Carbon nanoparticles of Chinese ink-wrapped natural loofah sponge: a low-cost three-dimensional electrode for high-performance microbial energy harvesting
Authors: Zhou Lihua , Sun Lihua , Fu Peng , Yang Chunli , Yuan Yong
Published: June 2017

A new highly conductive and biocompatible three-dimensional electrode with low-cost natural loofah sponge as the skeleton and Chinese ink as the conductive coating material is presented.
Novel method for the fabrication of ultrathin, free-standing and porous polymer membranes for retinal tissue engineering
Authors: Tan Edgar Yong Sheng , Agarwala Shweta , Yap Yee Ling , Tan Colin Siang Hui , Laude Augustinus , Yeong Wai Yee
Published: June 2017

Retinal degeneration causes permanent visual loss and affects millions of people worldwide.
Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling
Authors: Funami Kenji , Matsumoto Misako , Oshiumi Hiroyuki , Inagaki Fuyuhiko , Seya Tsukasa
Published: June 2017

Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS), produces pro-inflammatory cytokines and type I interferons, and associates with a trigger of endotoxin shock. TLR4 is interacted with a TIR domain-containing adaptor molecule-2 (TICAM-2)/TRAM [TRIF (TIR domain-containing adaptor-inducing interferon-β)-related adaptor molecule] via its Toll–interleukin-1 receptor homology (TIR) domain. TICAM-2 acts as a scaffold protein and activates TIR domain-containing adaptor molecule-1 (TICAM-1)/TRIF. According to the structural analysis by NMR, TICAM-2 interacts with TICAM-1 by the acidic amino acids motif, E87/D88/D89. The TIR domain of TICAM-2 couples with the dimer of TIR domain of TLR4 beneath the membrane, and TICAM-2 itself also forms dimer and constitutes a binding site with TICAM-1. Endosomal localization of TICAM-2 is essential for TLR4-mediated type I interferon-inducing signal from the endosome. N-terminal myristoylation allows TICAM-2 to anchor to the endosomal membrane. Additionally, we have identified two acidic amino acids, D91/E92, as a functional motif that cooperatively determines endosomal localization of TICAM-2. This structural information of TICAM-2 suggests that the specific structure is indispensable for the endosomal localization and type I interferon production of TICAM-2. Taken together with the knowledge on cytoplasmic sensors for LPS, TICAM-2/TICAM-1 may conform to a signal network on TLR4 to facilitate induction of cytokine disorders.
Structure and function of DHHC protein S-acyltransferases
Authors: Gottlieb Colin D. , Linder Maurine E.
Published: June 2017

It has been estimated that 10% of the human genome encodes proteins that are fatty acylated at cysteine residues. The vast majority of these proteins are modified by members of the DHHC protein family, which carry out their enzymatic function on the cytoplasmic face of cell membranes. The biomedical importance of DHHC proteins is underscored by their association with human disease; unique and essential roles for DHHC proteins have been uncovered using DHHC-deficient mouse models. Accordingly, there is great interest in elucidating the molecular mechanisms that underlie DHHC protein function. In this review, we present recent insights into the structure and function of DHHC enzymes.
The convergence of nonnegative solutions for the family of problems −Δpu=λeuasp→∞
Authors: Mihăilescu Mihai , Stancu−Dumitru Denisa , Varga Csaba
Published: June 2017

LetΩ⊂ ℝN(N≥ 2) be a bounded domain with smooth boundary. We show the existence of a positive real numberλ*such that for eachλ∈ (0,λ*) and each real numberp>Nthe equation −Δpu = λeuinΩsubject to the homogeneous Dirichlet boundary condition possesses a nonnegative solutionup. Next, we analyze the asymptotic behavior ofupas p→∞and we show that it converges uniformly to the distance function to the boundary of the domain.
Advantages of the Microwave Tool in Organophosphorus Syntheses
Authors: Keglevich György , Kiss Nóra , Grün Alajos , Bálint Erika , Kovács Tamara
Published: June 2017

The microwave (MW) technique has become an important tool also in the organophosphorus field of organic chemistry. On the one hand, otherwise reluctant reactions, such as the esterification of P-acids, may be enhanced by the effect of MW, while on the other hand, catalysts may be omitted, or catalyst systems may be simplified on MW irradiation. This later group includes the Kabachnik–Fields reactions, alkylation of active methylene-containing compounds, O-alkylations, deoxygenations, as well as the Hirao reaction. It is also the purpose of this review to elucidate the scope and limitations of the MW tool, to interpret the MW effects, and to model the distribution of local overheatings and their beneficial effect.

1 Introduction

2 The Esterification of Phosphinic Acids

2.1 Synthetic Results

2.2 Scope and Limitation of the Application of MWs

2.3 Modelling the Distribution of the Local Overheatings and Predicting­ Their Effect

3 The Simplification of Catalytic Systems

3.1 Replacement of the Catalyst by MW Irradiation

3.1.1 The Kabachnik–Fields Reaction

3.1.2 Solid–Liquid Phase Alkylation of Active Methylene-Containing Compounds

3.1.3 Solid–Liquid Phase Alkylation of Phosphinic Acids

3.1.4 The Deoxygenation of Phosphine Oxides

3.2 The Hirao Reaction without Added P-Ligands

4 Conclusions
Oxidative Cleavage of Enamides with Hypervalent Iodine(III)/TMSN3 under an Air Atmosphere
Authors: Liu Ge , Li Yan , Sheng Jie , Wang Xi-Sheng
Published: June 2017

An oxidative cleavage of C–C double bonds of enamides promoted by hypervalent iodine(III)/TMSN3 under an air atmosphere is developed. This reaction provides a new approach to construct various cyanobenzamides, which offers further synthetic potential for the preparation of industrial and pharmaceutical nitrogen- and oxygen-containing molecules, and exhibits good functional group tolerance, broad substrate scope and mild conditions.
Peritoneal Dialysis Catheter Position Evaluated by Ultrasound: Can it Replace Abdomen X-Ray in Patients Presenting Catheter Misplacement?
Authors: Zeiler Matthias , Zanoli Luca , Scarfia Rosalia , Santarelli Stefano , Granata Antonio
Published: June 2017

Background Malfunction of the peritoneal dialysis catheter is frequently caused by dislocation. The diagnostic approach is classically based on abdomen X-ray together with detailed case history and physical examination. Despite being rarely applied in clinical practice to evaluate catheter misplacement, ultrasound is a noninvasive, radiation-free technique that is potentially useful also to explore reasons for catheter malfunction. Consequently, we aimed to evaluate the diagnostic accuracy of ultrasound to identify peritoneal catheter misplacement.

Methods In a multicenter observational blinded study, we compared ultrasound to abdomen X-ray for catheter localization in 93 consecutive peritoneal dialysis patients with dialysate outflow problems enrolled in two nephrology and dialysis units. The position of the catheter was annotated on a standard scheme of nine abdominopelvic regions. The sensitivity, specificity, positive and negative predictive value and Kappa coefficient were calculated.

Results Dislocation out of the inferior abdominopelvic regions was present in 19 patients (20 %) at X-ray and 23 patients (25 %) at ultrasound. Correct determination of the position of the catheter in the lower abdomen by ultrasound had a sensitivity of 93 % (95 % CI 84 – 97 %), specificity of 95 % (95 % CI 72 – 100 %), positive predictive value of 99 % (95 % CI 91 – 100 %), negative predictive value of 78 % (95 %CI 56 – 92 %) and Kappa coefficient of 0.82 (95 % CI 0.67 – 0.96). In 10 out of 93 patients (11 %), there was a position mismatch between X-ray and ultrasound in an adjacent abdominopelvic region.

Conclusion Our results suggest that abdomen X-ray for the evaluation of peritoneal catheter position can be replaced by ultrasound in experienced hands. This bedside diagnostic procedure might reduce costs, the time necessary for diagnosis and lifetime radiation exposure.
Verringerung von Beschwerden des Stütz- und Bewegungsapparats
Authors: Hucke Stephanie , Berg Ralf , Thiem Hendrik , Schultz Norbert , Wegener Tankred
Published: June 2017

Bei der Behandlung von Beschwerden im Stütz- und Bewegungsapparat stehen Schmerzreduktion und Steigerung der Beweglichkeit im Fokus.

In einer offenen, nichtinterventionellen Studie (NIS; Beobachtungsstudie) erhielten 142 Patienten über einen Zeitraum von 3 Monaten das homöopathische Komplexmittel Ranocalcin, das für Schwächezustände des Stütz- und Bindegewebes und der Knochen zugelassen ist.

Zu Studienbeginn sowie nach 6 Wochen und 3 Monaten wurde der klinische Befund durch den Arzt erhoben; die Patienten wurden für eine subjektive Bewertung ihrer Beschwerden befragt. Zudem erfolgte eine allgemeine Bewertung der Wirksamkeit und Verträglichkeit.

Ergebnisse: Die Patienten berichteten eine merkliche Reduktion von Rücken- und Gelenkschmerzen. Dies deckte sich mit dem klinischen Befund einer deutlich verbesserten Beweglichkeit mit gleichzeitig reduzierter Schonhaltung. Die Ergebnisse der Beobachtungsstudie weisen auf eine mögliche Wirksamkeit in diesem Anwendungsgebiet bei guter Verträglichkeit des Komplexmittels hin.
Ideas, structures, and the (un)conventional politics of minority rights in Romania and Ukraine
Authors: Fedotov Egor
Published: June 2017

This article uses a paired comparison of ethnic politics in postcommunist Romania and post-Soviet Ukraine to explore the example of language policy implementation, empirically speaking. It argues that the (variable) behaviours of linguistic minority elites—the Hungarians in Romania and the Russophones in Ukraine—are driven by elites’ ideas (or ideational elements), theoretically speaking. In Romania, a politics of interethnic compromise and thequid pro quogained the upper hand. In Ukraine, a politics of confrontation carried the day. In these two cases, the divergence—in behavioural terms—had had far-reaching political consequences, the latter affecting the level of cooperation and the amount of trust amongst the ethnic groups. These findings enrich our understanding of the behaviour of these particular groups in politics and of the policies toward them.
The Emergence of Openness in Open-Source Projects: The Case of OpenEhR
Authors: Curto-Millet Daniel , Shaikh Maha
Published: June 2017

The meaning of openness in open source is both intrinsically unstable and dynamic, and tends to fluctuate with time and context. We draw on a very particular open-source project primarily concerned with building rigorous clinical concepts to be used in electronic health records called openEHR. openEHR explains how openness is a concept that is purposely engaged with, and how, in this process of engagement, the very meaning of open matures and evolves within the project. Drawing on rich longitudinal data related to openEHR we theorise the evolving nature of openness and how this idea emerges through two intertwined processes of maturation and metamorphosis. While metamorphosis allows us to trace and interrogate the mutational evolution in openness, maturation analyses the small, careful changes crafted to build a very particular understanding of openness. Metamorphosis is less managed and controlled, whereas maturation is representative of highly precise work carried out in controlled form. Both processes work together in open-source projects and reinforce each other. Our study reveals that openness emerges and evolves in open-source projects where it can be understood to mean rigour; ability to participate; open implementation; and an open process. Our work contributes to a deepening in the theorisation of what it means to be an open-source project. The multiple and co-existing meanings of ‘open’ imply that open-source projects evolve in nonlinear ways where each critical meaning of openness causes a reflective questioning by the community of its continued status and existence.
In-vacuum sensors for the beamline components of the ITER neutral beam test facility
Authors: Dalla Palma M. , Pasqualotto R. , Sartori E. , Spagnolo S. , Spolaore M. , Veltri P.
Published: June 2017

Embedded sensors have been designed for installation on the components of the MITICA beamline, the prototype ITER neutral beam injector (Megavolt ITER Injector and Concept Advancement), to derive characteristics of the particle beam and to monitor the component conditions during operation for protection and thermal control. Along the beamline, the components interacting with the particle beam are the neutralizer, the residual ion dump, and the calorimeter. The design and the positioning of sensors on each component have been developed considering the expected beam-surface interaction including non-ideal and off-normal conditions. The arrangement of the following instrumentation is presented: thermal sensors, strain gages, electrostatic probes including secondary emission detectors, grounding shunt for electrical currents, and accelerometers.