bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic
Acid in Renal Transplant Recipients
Authors: Liu Jiawen , Tan Ruoyun , Gu Min , Wang Zijie , Zhu Yongqian , Zhang Jiexiu , Wei Jintao , Zheng Ming , Gui Zeping , Chen Hao , Sun Li , Han Zhijian , Tao Jun , Ju Xiaobin
Published: February 2023

Aims:

This study was designed to analyze the correlation between single nucleotide polymorphisms
(SNP) related to drug metabolism and pharmacokinetics of mycophenolic acid (MPA) during long-term follow-up.

Materials and Method:

A retrospective cohort study involving 71 renal transplant recipients was designed. Blood
samples were collected to extract total DNAs, followed by target sequencing based on next-generation sequencing
technology. The MPA area under the curve (AUC) was calculated according to the formula established in our center.
The general linear model and linear regression model were used to analyze the association between SNPs and MPA
AUC.

Results:

A total of 689 SNPs were detected in our study, and 90 tagger SNPs were selected after quality control and
linkage disequilibrium analysis. The general linear model analysis showed that 9 SNPs significantly influenced MPA
AUC. A forward linear regression was conducted, and the model with the highest identical degree (r2=0.55) included
4 SNPs (SLCO1B1: rs4149036 [P < 0.0001], ABCC2: rs3824610 [P = 0.005], POR: rs4732514 [P = 0.006], ABCC2:
rs4148395 [P = 0.007]) and 6 clinical factors (age [P < 0.0001], gender [P < 0.0001], the incident of acute rejection
(AR) [P = 0.001], albumin [P < 0.0001], duration after renal transplantation [P = 0.01], lymphocyte numbers [P =
0.026]). The most relevant SNP to MPA AUC in this model was rs4149036. The subgroup analysis showed that
rs4149036 had a significant influence on MPA AUC in the older group (P = 0.02), high-albumin group (P = 0.01),
male group (P = 0.046), and both within-36-month group (P = 0.029) and after-36-month group (P = 0.041). The
systematic review included 4 studies, and 2 of them showed that the mutation in SLCO1B1 resulted in lower MPA
AUC, which was contrary to our study.

Conclusion:

A total of 4 SNPs (rs4149036, rs3824610, rs4148395, and rs4732514) were identified to be significantly
correlated with MPA AUC. Rs4149036, located in SLCO1B1, was suggested to be the most relevant SNP to MPA
AUC, which had a stronger influence on recipients who were elder, male, or with high serum albumin. Furthermore,
6 clinical factors, including age, gender, occurrence of acute rejection, serum albumin, time from kidney transplantation,
and blood lymphocyte numbers, were found to affect the concentration of MPA.
Comprehensive Study of In vivo and In vitro Metabolites of Cycloastragenol Based on
UHPLC-Q-Exactive Orbitrap Mass Spectrometer
Authors: Li Huajian , Wang Shaoping , Wang Hong , Li Haoran , Li Yanan , Dong Pingping , Lan Xianming , Zhang Jiayu , Dai Long
Published: February 2023

Background:

Cycloastragenol (CAG) is a sapogenin derived from the main bioactive constituents of
Astragali Radix (AR). However, the current research on CAG metabolism in vivo and in vitro is still inadequate, and
the metabolite cluster is incomplete due to incomplete analysis strategy.

Objective:

The objective of this study was to screen and identify the metabolic behavior of CAG in vivo and in vitro.

Methods:

A simple and rapid analysis strategy based on UHPLC-Q-Exactive Orbitrap mass spectrometry combined
with data-mining processing technology was developed and used to screen and identify CAG metabolites in rat body
fluids and tissues after oral administration.

Results:

As a result, a total of 82 metabolites were fully or partially characterized based on their accurate mass, characteristic
fragment ions, retention times, corresponding Clog P values, and so on. Among the metabolites, 61 were
not been reported in previous reports. These metabolites (6 metabolites in vitro and 91 in vivo) were generated
through reactions of hydroxylation, glucuronidation, sulfation, hydrogenation, hydroxylation, demethylation,
deisopropylation, dehydroxylation, ring cleavage, and carboxyl substitution and their composite reactions, and the
hydroxylation might be the main metabolic reaction of CAG. In addition, the characteristic fragmentation pathways
of CAG were summarized for the subsequent metabolite identification.

Conclusion:

The current study not only clarifies the metabolite cluster-based and metabolic regularity of CAG in
vivo and in vitro, but also provides ideas for metabolism of other saponin compounds.
Convalescent Plasma Therapy against COVID-19: An Update on the
Changing Facets of the ongoing Pandemic
Authors: Abullais Saquib Shahabe , Arora Suraj , Wahab Shadma , Grover Vishakha , Alshahrani Mohammed Yahya , Shamsudeen Shaik Mohamed , Mohammed  Asif Shaik , Faragalla Amel Ibrahim , Elagib Mohamed Fadul
Published: February 2023

The severe respiratory infections in the current pandemic coronavirus disease-19
(COVID-19) have influenced more or less every human life. The first person to get infected with
this virus was reported in the capital of Hubei province (Wuhan), China, in late December 2019.
Since the disease has been declared a pandemic, research scholars and experts have been manufacturing
new vaccines or targeted therapies to curb the spread of SARS-CoV-2. However, only limited
options have emerged so far, which yet require complete scientific validation by long-term data
collection regarding safety and efficacy. In the wake of the recent emerging wave of the pandemic
viz omicron variant, changing facets of the viral genome and dearth of preventative and therapeutic
possibilities for the management of COVID-19, the usage of Convalescent Plasma Therapy (CPT)
may be looked at as a potentially viable option of treatment in the existing situation. Earlier, immune
plasma has been used with success in the management of H1N1 influenza virus, MERS-CoV,
and SARS-CoV-1 epidemics. In the present unpredictable situation created by the COVID-19 pandemic,
the CPT is used with a positive outcome amongst many infected individuals in different
parts of the world with acceptable efficacy. This article aimed to present an up-to-date evaluation of
existing literature on the efficacy of convalescent plasma as a potential therapy, its safety and effectiveness
and the challenges in treating COVID-19.
Formulation and Characterization of Phytosomes as Drug Delivery System
of Formononetin: An Effective Anti-Osteoporotic Agent
Authors: Agarwal Arun , Wahajuddin Muhammad , Chaturvedi Swati , Singh Sandeep K. , Rashid Mamunur , Garg Richa , Chauhan DIvya , Sultana Nazneen , Gayen Jiaur R.
Published: February 2023

Background:

Formononetin (FNT), a methoxy isoflavone, is a potential phytoconstituent
utilized for refurbishing fractures in bone tissue. Conceding to its involvement in first-pass metabolism
followed by glucuronidation, its absorption efficacy is limited. Hence, it belongs to the BCS class II
classification.

Objective:

We designed the present work to enhance FNT oral bioavailability by using Phospholipids
(PL) as a promising carrier. Formononetin Phospholipid Complex (FNT-PC) was prepared by the solvent
evaporation method and characterized.

Method:

FNT-PC was prepared by solvent evaporation method and characterization (FNT-PC) was
performed using aqueous/n-octanol solubility and partition coefficient, FTIR, NMR, SEM, and in vivo
pharmacokinetic study in female SD rats at 50 mg/kg.

Results:

Physicochemical properties like aqueous/n-octanol solubility and partition coefficient were
enhanced in FNT-PC. The FTIR spectrum confirmed there was no involvement of functional groups in
the preparation of FNT-PC. Whereas, the NMR study resulted in the attachment of carbon (C-8) position
of FNT by replacing the quaternary amine of PL to form FNT-PC. When scrutinized for its surface
morphology, the FNT-PC exhibited the amorphous geometry that remarkably enhanced the dissolution
of FNT (p<0.05) from its pure form. This dissolution effect was also affirmed by the per-oral administration
of FNT-PC in female Sprague Dawley (SD) rats at 50 mg/kg dose. The pharmacokinetic profile
showed the free FNT levels were markedly increased, correspondingly decreasing the conjugated
FNT levels in rat plasma.

Conclusion:

To summarize, FNT-PC could substantially reduce the first-pass metabolism with enhanced
free concentration, improving oral bioavailability for therapeutic use.
Paeonol Attenuates the Endothelial-to-Mesenchymal Transition Induced
by TGF-β1 in Human Umbilical Vein Endothelial Cells through ALK5-
Smad2/3 Signaling Pathway
Authors: Dai Min , Yang Yulong , Liang Yuning , Shi Xiaoyan , Wu Hongfei , Liu Yarong , Jiang Tingting , Yan Jinjin , Zhou Min , Gao Menglong
Published: February 2023

Background:

Paeonol (Pae), the main active compound of the root of Paeonia albiflora,
is efficacious in treating atherosclerosis (AS). Endothelial dysfunction is throughout the pathological
progression of AS. It is expected that inhibition of Endothelial-to-mesenchymal transition
(EndMT) will be a key target for AS treatment.

Objective:

In this study, we investigated the molecular mechanism of the regulatory effect of Pae
on EndMT in human umbilical vein endothelial cells (HUVECs).

Methods:

Cell cytotoxicity, proliferation, and migration were detected by CCK-8, the wound healing
assay, and EdU staining, respectively. The protein expressions were measured by Western blot
or immunofluorescence staining. Immunofluorescence staining was performed to indicate endothelial
cells undergoing EndMT in ApoE-/- mice. In vitro TGF-β1-induced EndMT assays were performed
in HUVECs and the effect of Pae was explored.

Results:

We demonstrated that Pae could improve induced TGF-β1-EndMT in vivo and in vitro.
Mechanism study revealed that Pae directly bonds to the activin-like kinase 5 (ALK5, also known
as TGFβ type I receptor), inhibited downstream Smad2/3 phosphorylation, and thus alleviated
EndMT. Notably, overexpression of ALK5 significantly reversed the inhibitory effect of Pae on
EndMT in HUVECs.

Conclusion:

Our results indicate that ALK5 is a promising druggable target for AS, and pharmacological
regulation of ALK5-Smad2/3 signaling pathway with small-molecule holds great potential
to benefit AS patients.
An Observational Study on HIV and Syphilis Rates and Associated Risk
Factors among Elderly Men in Wuxi, China
Authors: Huang Hao , Cao Yuxin , Li Min , Bao Yining , Robbins Sarah , Chu Minjie , Gu Jing , Meng Xiaojun , Zhuang Xun
Published: February 2023

Background:

Acquired Immune Deficiency Syndrome (AIDS) remains a nationwide
health problem in China; there were a reported 1,045,000 people living with Human immunodeficiency
virus (HIV)/AIDS by the end of October 2020, and the proportion of individuals aged 50
years and older living with HIV has also increased from 8% to 24% over the past two decades.

background:

Human immunodeficiency virus (HIV) remains a nationwide health problem in China, there were a reported 1,045,000 people living with HIV/Acquired Immune Deficiency Syndrome (AIDS) by the end of October 2020, and the number of individuals aged over 50 years living with HIV has also increased over the past two decades.

Methods:

A cross-sectional study and an 1:2 matched case-control study were conducted from July
to August 2016, in Wuxi city, eastern China. A total of 1,000 men aged 50 years and older completed
a face-to-face interview regarding their AIDS-related knowledge and attitudes, as well as risk
behaviors.

Results:

Prevalence was 0.1% for HIV and 2% for syphilis. The awareness rate of AIDS-related
knowledge among elderly men was 48.9% (range 40.7%-63.9%). The 1꞉2 matched case-control
study indicated that only the AIDS-related attitudes were different between the two groups
(χ2=8.726, P=0.013), the conditional logistic regression analysis indicated that scores of AIDS
health knowledge were the only significant prognostic factor for the infection (HR=0.754 (0.569-
0.999), P=0.049).

method:

A cross-sectional study and an 1:2 matched case-control study were conducted from July to August 2016, in Wuxi city, eastern China. A total of 1000 men aged over 50 years completed a face-to-face interview regarding their HIV-related knowledge and attitudes, as well as risk behaviors.

Conclusion:

It was crucial to prevent HIV/AIDS and syphilis infections by improving the awareness
of AIDS-related knowledge and changing related attitudes among the elderly. Further research
aimed at identifying how these factors impact their sexual decision-making can shed valuable insight
into further prevention program in this population.
Synthesis and Applications of N-Alkoxymethylated Azaheterocycles
Authors: Gondal Humaira Y. , Nisar Muhammad , Cheema Zain M. , Iqbal Kiran , Munir Akhtar , Zaidi Sadia , Abbas Khan Ahmed
Published: February 2023

Alkoxmethyl heterocycles play a significant role as bioactive compounds in pharmaceutical
and bifunctional ligands in synthetic organic chemistry. N-Alkoxmethylation can lead toward multipurpose
mixed acetals, natural product precursors, and task-specific functionalized ionic liquids. This
report provides a comprehensive account of the synthesis and perspectives applications of alkoxymethyl
azaheterocycles. The first part gives a detailed account of the different synthetic strategies employed
to access N-alkoxy methyl heterocyclic compounds. The second part deals with their applications,
owing to the unique reactivity of the alkoxymethyl group and the nature of heterocycle. Besides
diverse biological and synthetic applications, alkoxymethyl benzotriazoles also provide substantial
scope as a versatile anion stabilizer that can lead to diverse oxygen functionalities.
Hypoperfusion Intensity Ratio Correlates with Angiographic Collaterals
and Infarct Growth in Acute Stroke with Thrombectomy
Authors: Ai Zhongping , Jiang Liang , Zhao Boxiang , Su Haobo , Yin Xindao , Chen Yu-Chen
Published: February 2023

Background:

The assessment of collaterals before endovascular thrombectomy (EVT) therapy
play a pivotal role in clinical decision-making for acute stroke patients.

Objective:

To investigate the correlation between hypoperfusion intensity ratio (HIR), collaterals on
digital subtraction angiography (DSA), and infarct growth in acute stroke patients who underwent EVT
therapy.

Methods:

Patients with acute ischemic stroke (AIS) who underwent EVT therapy were enrolled retrospectively.
HIR was assessed through magnetic resonance imaging (MRI) and was defined as the
Tmax > 10 s lesion volume divided by the Tmax > 6 s lesion volume. Collaterals were assessed on
DSA using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional
Radiology (ASITN/SIR) scale. Good collaterals were defined as ASITN/SIR score 3–4 and
poor collaterals were defined as ASITN/SIR score 0–2. Spearman’s rank correlation analysis was used
to evaluate the correlation between HIR, collaterals, infarct growth, and functional outcome.

Results:

A total of 115 patients were included. Patients with good collateral (n = 59) had smaller HIR
(0.29 ± 0.07 vs. 0.52 ± 0.14; t = 10.769, P < 0.001) and infarct growth (8.47 ± 2.40 vs. 14.37 ± 5.28; t =
7.652, P < 0.001) than those with poor collateral (n = 56).

Discussion:

The ROC analyses showed that the optimal cut-off value of HIR was 0.40, and the sensitivity
and specificity for predicting good collateral were 85.70% and 96.61%, respectively. With the
optimal cut-off value, patients with HIR < 0.4 (n = 67) had smaller infarct growth (8.86 ± 2.59 vs.
14.81 ± 5.52; t = 6.944, P < 0.001) than those with HIR ≥ 0.4 (n = 48). Spearman’s rank correlation
analysis showed that HIR had a correlation with ASITN/SIR score (r = -0.761, P < 0.001), infarct
growth (r = 0.567, P < 0.001), and mRS at 3 months (r = -0.627, P < 0.001).

Conclusion:

HIR < 0.4 is significantly correlated with good collateral status and small infarct growth.
Evaluating HIR before treatment may be useful for guiding EVT and predicting the functional outcome
of AIS patients.
Apoptosis and Remodeling in Ovary of Water Deer and Sika Deer at Pregnant and Non-pregnant Stages
Authors: Lee Ji-Hye , Park Yong-Su , Oh Min-Gee , Kim Sang-Hwan
Published: February 2023

Background:

Many studies have been conducted on the sika deer, an extinct species in Korea, to analyze the physiological characteristics of restoration and reproductive physiological characteristics. The reproductive physiological mechanisms of water deer and sika deer, especially the function, morphological changes, and ovarian characteristics, are unknown.

Objective:

We aimed to study the differences in the reproductive physiology of water deer and sika deer and determine the difference in function through ovarian morphological analysis and cell remodeling.

Methods:

Water deer and sika deer ovaries were collected during the estrus and pregnancy seasons from the Korean Peninsula and Russia–Korean Peninsula border, respectively, and analyzed. Morphological analysis and in situ zymography were conducted to confirm the activity of matrix metalloproteinases (MMPs), analyze the immunofluorescence of Casp-3 protein, and assess the morphological changes in the ovaries.

Results:

The results of the analysis confirmed the ovaries of water deer and sika deer to be morphologically different. The corpus luteum of sika deer showed large differences in size and morphology compared to water deer, and many changes were also observed in the corpus luteum cells. However, the activity of MMPs and apoptosis in the follicles of sika deer were higher than those of water deer. Water deer and sika deer showed similar corpus luteum patterns during estrus and pregnancy.

Conclusion:

In our study, morphological differences were found to be present between water deer and sika deer ovaries; however, cell remodeling demonstrated a similar pattern. Therefore, the endocrine function and reproductive efficiency for reproduction would be similar.
Entropy Generation Effects on Hydromagnetic Williamson Nanofluid
Flow through a Porous Media
Authors: Mondal Sabyasachi , Ghosh Riya , Sharma Ram Prakash
Published: February 2023

Background:

Two-dimensional Williamson nanofluid flow with magnetic effects occurs
through an extending surface immersed in a porous media. This includes the impact of the applied
magnetic field, chemical reactions, variable thermal conductivity, and heat generation. Based on the
above assumption, this study investigates a hydromagnetic Williamson nanofluid passed through a
stretching surface embedded in a porous media that is being analysed by assuming the impact of thermal
radiation and magnetic field on the flow properties.

Methods:

After using an appropriate similarity transformation, the governing equations with boundary
conditions were converted into a dimensionless form. These derived ordinary differential equations are
highly nonlinear partial differential equations that are solved numerically using the spectral local
linearisation method.

Results:

An analysis and comparison of results with existing literature are reported here. Excellent
agreement has been found between our results and those previously published. The impact of the
magnetic field parameters, heat generation, variable thermal conductivity, and chemical reaction
parameters on the velocity, thermal, and concentration profiles are inspected in graphical and tabular
forms

Conclusion:

The outcomes indicate that the velocity reduces with the increase in Williamson, porosity,
and magnetic field parameters, whereas the concentration profile improves with these parameters.
Entropy generation rate is also enhanced when the concentration difference parameter, Reynolds number,
and Brinkman number are increased. Our results are extremely relevant and prove the same. A rise in the
porosity parameter drops the velocity profiles but increases the temperature and concentration profiles.
The entropy generation number is enhanced when the concentration difference parameter, Reynolds, and
Brinkman numbers are increased.
Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic
Kidney Disease of Unknown Etiology in Sri Lanka
Authors: Edirithilake Thanuri , Nanayakkara Nishantha , Lin Xiao Xiao , Biggs Patrick J. , Chandrajith Rohana , Lokugalappatti Sampath , Wickramasinghe Saumya
Published: February 2023

Background:

Chronic kidney disease of unknown etiology (CKDu) is reported among male paddy farmers in the dry zone of Sri Lanka. The exact cause of this disease remains undeter-mined. Genetic susceptibility is identified as a major risk factor for CKDu.

Objectives:

In this study, small urinary RNAs were characterized in CKDu patients, healthy endem-ic and non-endemic controls. Differently expressed urinary miRNAs and their associated pathways were identified in the study population.

Methods:

Healthy and diseased male volunteers (n = 9) were recruited from Girandurukotte (en-demic) and Mawanella (non-endemic) districts. Urinary small RNAs were purified and sequenced using Illumina MiSeqTM. The sequence trace files were assembled and analyzed. Differentially ex-pressed miRNAs among these three groups were identified and pathway analysis was conducted.

Results:

The urine samples contained 130,623 sequence reads identified as non-coding RNAs, PIWI-interacting RNAs (piRNA), and miRNAs. Approximately four percent of the total small RNA reads represented miRNA, and 29% represented piRNA. A total of 409 miRNA species were ex-pressed in urine. Interestingly, both diseased and endemic controls population showed significantly low expression of miRNA and piRNA. Regardless of the health status, the endemic population ex-pressed significantly low levels of miR-10a, miR-21, miR-148a, and miR-30a which have been linked with several environmental toxins.

Conclusion:

Significant downregulation of miRNA and piRNA expression in both diseased and healthy endemic samples indicates an epigenetic regulation of CKDu involving genetic and envi-ronmental interaction. Further studies of specific miRNA species are required to develop a miRNA panel to identify individuals susceptible to CKDu.
Comparison of Malay and Banjarese vocabulary in Upin and Ipin animated films
Authors: Rafiek Muhammad , Nisa Raudhatun
Published: February 2023

This research aims to identify, define and explain the similarities and differences between Banjarese from Malay vocabularies in Upin and Ipin animated film, entitled Penjaga Baru. Vocabulary theory from Schmitt (2000), narrative text theory from Purba (2018) and Lirola (2018), procedural text theory from Delpech and Dizier (2008), and Dautriche and Dizier (2009) were used. A qualitative descriptive method was used with download, view and listen, and type techniques. As a result, identical spelling and pronunciation have been discovered in the Banjar and Malay languages. Banjarese vocabulary also had different spellings and pronunciations but had the same meaning as Malay. These vocabularies can be used as Banjar language teaching materials. Certain stories were also discovered in Upin and Ipin animated film titled Penjaga Baru, which could be developed into a narrative text in Indonesian titled Atok Dalang, Upin, dan Ipin mencari dan memasak siput sedut serta Atok Dalang, Upin, dan Ipin mencari buah durian (Atok Dalang, Upin, and Ipin look for and cook mud creeper snails with durian fruit) in Indonesian. Furthermore, a procedural text entitled Atok Dalang memasak siput sedut dan Atok Dalang membuat tempoyak (Atok Dalang cooks sedut snails and makes tempoyak) in Indonesian.
Clinical study on the effectiveness of Vatagajankusha Rasa with Pippali Churna and Manjishta Kwatha as Anupana in Apabahuka (Frozen Shoulder)
Authors: Muzammil Kamatagi  , Lakshmiprasad L. Jadhav
Published: February 2023

Apabahuka is a Vatavyadhi, localizing around the Amsapradesh and thereby causing of Amsa Bandha as well Aakuncana of Sira leading to symptoms like Bahupraspandita Hara. Amsashosha can be considered as the preliminary stage of the disease where loss or dryness of the Shleshakakapha from the shoulder joint occurs. In the next stage, due to the loss of Shleshakakapha symptoms like pain during movement, restricted movement are manifested. Vatagajankusha Rasa with Pippali Churna and Manjisthakwatha as Anupana is mentioned in the treatment of Apabahuka under the Vatavyadhichikitsa. The duration of intervention is 7 days as per the reference. Hence this study is intended to validate the same. Objective: Considering the prevalence, and lifestyle effect on patients, to evaluate the effectiveness of Vatagajankusa Rasa and Manjisthakashaya, Pippali Churna in Apabahuka. (Frozen Shoulder). Methodology: Among 34 registered subjects 28 completed the course of treatment. They were administered with Vatagajankusha Rasa (125mg) with Pippali Churna (3gm) and Manjishta Kwatha (15ml) as Anupana before food twice daily for a period of 7 days. For statistical analysis subjective and objective parameters were assessed by Wilcoxon signed rank, McNemar test and paired T test. Result: In the parameters of Apabahuka, the intervention was found to be statistically significant in relieving the assessment parameters like Amsa Sandhi Shoola, Bahupraspandita Hara (p < 0.005). In Objective parameters like ROM of Shoulder significant relief was observed after statistical analysis. Conclusion: Vatagajankusha Rasa with Pippali Churna and Manjishta Kwatha as Anupana is effective in the management of symptoms of Apabahuka
A comparative clinical study to evaluate the efficacy of Agnikarma by Panchaloha Shalaka and electric cautery in the management of Bahya Arshas with special reference to sentinel pile
Authors: Anandkumar C  , C Thyagaraja
Published: February 2023

Background - The diseases Arsha is considered to be a Mahagada according to the Ayurveda. Among the different types of Arshas explained by the Acharya Sushruta the Lakshanas of Bahya Arshas is looks similar to the structural presentation of the Sentinel pile. This condition, even though rarely fatal, gives more trouble to the sufferer and pose great difficulty for treatment. As we know the Sentinel pile is guarding to the fissure not to heal so keeping in view this clinical study Agnikarma with Panchaloha Shalaka and Electric Cautery was selected to give new dimension in the management of sentinel pile. Methodology - A comparative clinical study was done on forty subjects of both sexes, between the age group of 20-60 years who were randomly assigned into two groups, namely group A where Agnikarma by Panchalaoha Shalaka was used to the subjects and group B where Agnikarma by Electric Cautery was used to the subjects. After completion of the study, results were assessed using ‘Wilcoxon signed rank test’ for Single group and ‘Mann-whitney u-test’ for comparative Analysis for collected during the study. Result - Statistically Both group proved to be equally Significant. But according to the relief got by the patients Group-A proved to be more effective than group-B.  Group-A overall result is 95.71% and Group-B overall result is 91.79%.
A comparative clinical study on the efficacy of Nityanand Ras with (or) without Jeernakarkaruka Nasya in Hypothyroidism
Authors: Chandrika Kuraakula  , Srikanth Babu Perugu
Published: February 2023

Hypothyroidism also known as underactive thyroid gland, where the gland fails to produce enough thyroid hormones to meet the demands of physical body. The thyroid gland is a small approximately two inches butterfly shaped gland, situated in the anterior aspect of the throat regulates the way the body uses its energy, including the way how one’s heart beats. The normal functioning of this organ is very crucial for the metabolic homeostasis of the body. The rapid changes in the lifestyle and stressful life events are leading to the major disturbance of the normal metabolic functions of the human body, in Ayurveda the signs and symptoms of Hypothyroidism may be superficially compared to Atihraswa (dwarfism) and Atisthula (Obesity), but apart from this also, based on the other visible signs and symptomatology, the disease may be understood and treated accordingly. It is also can be considered as an Santarpanotta Vikara, since most of the Santarpanotta Vikara’s share common etio-pathogenesis. The Panchakarma treatment is known for removing the morbidity deeply from the body, and restores metabolic homeostasis. With this approach the current study was designed to observe the efficacy of Nityananda Ras, which is indicated in the Shlipada Adhikara of Bhaishajya Ratnavali, in the management of HT, and also in comparison with Nasya Karma, since the nasal administration of medicine is the best root for the elimination of the diseases of Head and neck. This research has shown the Nityanand Ras, is found effective and in the Nasya with Jeerna Karakaruka Swarasa group patients the results were encouraging in comparing with Nityanand Ras.
Women Mental Health w.s.r. to Premenstrual Syndrome - An Online Survey
Authors: Rajaput Suma , Sagare Sandeep , Yadav Anju , Sah Arpit
Published: February 2023

Introduction: Premenstrual syndrome (PMS) is a psycho neuroendocrine disorder of unknown aetiology. Prevalence of PMS is 47.8% in world-wide and in India it is 43%. It is mainly affecting mental health of the women, and quality of life of the women so this research was planned to explore the severity of the premenstrual syndrome and to evaluate the impact of PMS on Women mental health. Materials & Methods: Among 160 females, 130 females enrolled in the study based on criteria. The data was collected through Google form which was prepared based on PSST (premenstrual Symptom Screening Tool) Scale. Results: One hundred and twenty-two participants reported at least three somatic and two affective symptoms. 34.7% participants mentioned that PMS affects their quality of life. 30.3% participants reported mild, 24.6% female reported moderate, 10.7% reported severe and 7.4 % stated very severe. PMS significantly having relation with occupation, stress, and physical exercise. 57% participants reported that they are stressed due to any personal/ occupational issues. The participants who are doing regular exercise/ yoga are having less severity of symptoms compared to other participants. Discussion: This study reveals that PMS is common in almost all females but degree of severity differs. It affects both mental and physical health and also quality of life of the women. By this study additional thing we found that women who practice yoga, Pranayama, any physical exercise have less severity of premenstrual symptoms.
ÖĞRENCİLERE VERİLEN ÖDÜLLERİN ETKİLİLİĞİNE İLİŞKİN ÖĞRETMEN VE VELİ GÖRÜŞLERİ
Authors: Açıkgöz Bekir , Babaoğlan Emine
Published: February 2023

Bu araştırmanın amacı, öğrencilere verilen ödüllerin etkililiğine ve ödül verilmesiyle beklenen faydaların elde edilip edilemediğine ilişkin öğretmen ve veli görüşlerini ortaya çıkarmaktır. Araştırma nitel araştırma yönteminde ve fenomenoloji deseninde kurgulanmıştır. Araştırmada 2019-2020 eğitim öğretim yılı ikinci döneminde Yozgat ili Merkez ilçesinde görev yapan ortaokul öğretmenleri ile velilerin görüşlerine başvurulmuştur. Araştırmada veriler, öğretmen ve veli görüşme formlarıyla toplanmıştır. Verilerin analizinde içerik analizi tekniği kullanılmıştır. Araştırma sonuçlarına göre ödül yönteminin öğrencilerin akademik başarılarını artırmaya yönelik çalışmalarını desteklemek, ders etkinliklerine katılımı artırmak ve aile içinde olumlu davranışları artırmak için kullanıldığı görülmüştür. Ödül yönteminin öğrencilerin ders etkinliklerine katılımını artırdığı, motivasyonu yükselttiği ve çocukların olumlu davranışlarını artırdığı belirlenmiştir. Ödüller motivasyonu artırma, verilen görevleri yerine getirme, davranışları kısa sürede değiştirme ve ödev yaptırma konularında etkili bulunmuştur. Ödüllerin kalıcı davranış değişikliği yapmaması, etkisinin çok kısa olması, bazı öğrenciler için anlam ifade etmemesi, motive etme özelliğinin azalması ve ödülden beklenen etkinin elde edilememesi konularında da ödüllerin yeterli etkiye sahip olmadığı sonuçlarına ulaşılmıştır.
MESLEKİ EĞİTİMDE GELİŞİMSEL BİBLİYOTERAPİNİN KULLANILMASI: ÖĞRETMENLİK ALGISINA YANSIMALAR
Authors: Yüksek Usta Semiha , Kula Sultan Selen
Published: February 2023

Bu araştırma bibliyoterapi kullanımının öğretmen adaylarının öğretmenlik algısına etkisini inceleme amacıyla yapılmıştır. Yirmi dört sınıf öğretmeni adayı ile gerçekleştirilen araştırmada, Grigory Petrov tarafından yazılmış olan ve Türkçe’ye ilk kez 1928 yılında çevrilen, farklı ülkelerin egemenliğinde uzun yıllar yaşamış bir toplumun kalkınmasını ve kendi ayakları üzerinde durmasını konu edinen “Beyaz Zambaklar Ülkesinde” ve yine aynı yazarın bir matematik profesörü olan Raçinski’nin üniversitedeki görevinden istifa ederek doğduğu köye öğretmen olarak atanmasının gerçek öyküsünü ele alan “İdealist Öğretmen” isimli kitaplarını okumalarının öğretmen adaylarının mesleki algılarına katkıları incelenmiştir. Bu nitel araştırmada veriler öğretmen adaylarının kitaplara yönelik görüşlerini yazdıkları raporlardan içerik analizi ile analiz edilmiştir. Araştırma sonunda öğretmen adaylarının bibliyoterapi sürecinden sonra, bir öğretmenin pes etmeyen, fedakâr, değişime açık, kararlı, bilgili, iletişim becerisi yüksek, adil, sıra dışı, lider, ileri görüşlü, sabırlı ve risk alabilen kişilik özelliklerine sahip olması gerektiği, öğretmenlerin toplumun gelişmesi için çaba göstererek ve elini taşın altına koyarak toplumsal sorumluluklara sahip olması gerektiği yönünde bir algıya sahip oldukları ortaya konmuştur. Ayrıca aday öğretmenlerin bibliyoterapi sonrasında öğretmenlik mesleğinin toplumun herhangi bir grubuna, hiçbir ayrım gözetmeksizin kapsayıcı olması gerektiğini, karakter ve değerler eğitimine, öğrencilerin özgüvenlerinin geliştirilmesine, derslerin günlük hayatla ilişki kurularak ezberci yaklaşımlardan uzak işlenmesine dair içgörüye sahip oldukları saptanmıştır.
Anahtar Sözcükler: Öğretmen eğitimi, bibliyoterapi, beyaz zambaklar ülkesinde, idealist öğretmen, öğretmen adayı
A Study on the Mixed Article Name Jeogu(雎鳩): focusing on Three Books of Article Names in the late Joseon Dynasty
Authors:   The Association of DaeDong-Hanmun, Kim Dong-Surk
Published: February 2023

From ancient days, there were many controversies over whether a bird called Jeogu(저구) in the Volume of Gwanjeo(관저편), the first part of “the Book of Odes(시경)”, is a ferocious raptor (osprey) or a friendly raptor (a sort of wild duck). Because the Jeogu(저구) in the first verse of this poem is a symbol of ‘an elegant lady’ who will be an excellent spouse of a noble man, so whether this Jeogu(저구) is viewed as a bird of osprey or a sort of duck is an important key to understand the true meaning of four phrases in the first chapter of the Volume of Gwanjeo(관저편).
This paper attempts to identify the substance of the name Jeogu(저구) which has been confused or misunderstood over a long period of time, focusing on Three Books of Article Names - Wordbook of Things(재물보), Book of Article Names(물명고), Encyclopedia of Objects(광재물보) -, which emerged in the era when the study of names, objects, law, and numbers(명물도수) was prevalent in the late Joseon Dynasty.
When examining Chinese classics, it is understood that the confusion regarding the substance of “Jeogu(저구)” originated from the annotation of “Mosijuso(모시주소)”. The views of Chinese scholars views on the substance of ‘Jeogu’ have been debated for a long time, largely divided into one theory called a raptor and another theory called a sort of duck. It is understood that Three Books of Article Names adopted a raptor theory, a duck theory or a theory of the same name for different birds, depending on the type of Three Books of Article Names or by the classification of headwords from each Book.
From the viewpoint of today's standards, ‘Jeogu’ is an osprey[鶚], which is a raptor. If so, when interpreting the Book of Odes(시경), it is necessary to consider ‘摯而有別’ in Mojeon(모전) as 'it is fierce but it is good at discerning the mate (in terms of chastity).
Also, it was revealed that Jing-gyeong-yi(징경이, fish hawk), which traditionally referred to as “Jeogu(저구)”, originally indicated to a class of ducks called ‘Mandarin ducks’, but in modern times it has been misinterpreted as an osprey.
It is thought that the main cause of the constant confusion of the name of an object is usually misunderstanding and miswriting of the object. Due to the misunderstanding and miswriting, the confusion of objects has always been repeated or reproduced. Therefore, when encountering classics, it is necessary to pay attention to the above fact and to take a careful approach.
The acceptance and dissemination of “Shou su hui” by Joseon intellectuals in the 18C and 19C
Authors:   The Association of DaeDong-Hanmun, WANG JUAN
Published: February 2023

“Shou su hui” (Gathering for Su dongpo's Birthday Remembrance) is a cultural phenomenon popular in the Qing Dynasty. This paper discusses the origin and development of “Shou su hui” in the Qing Dynasty, and how it was introduced into the Joseon Dynasty through Joseon envoys, and sorted out the spread situation and reasons after it was introduced into the Joseon Dynasty. This paper mainly focuses on the analysis of the “Shou su hui” of Weng Fanggang(翁方綱), which played an important role in the development of the “Shou su hui” and played a decisive role in the introduction of “Shou su hui” into the Joseon Dynasty.
Through the historical materials of 燕行, the time and the process of “Shou su hui”'s introduction into the Joseon Dynasty were explored based on the friendship of Park Jae-ga(朴齊家), Kim Jeong-hui(金正喜), Shin Wi(申緯) and Weng Fanggang. This paper discusses the process which Joseon Dynasty intellectuals accepted the culture. By sorting out the poems related to the “Shou su hui” by the intellectuals of the Joseon Dynasty, this paper observes the spread situation of the “Shou su hui” among the intellectuals after it was introduced into the Joseon Dynasty, including the main groups and time distribution of the cultural activities. To compare with the “Shou su hui” of the Qing Dynasty before its introduction, this paper finds the difference between the Shousuhui which developed in combination with the native culture of the Joseon Dynasty and the previous “Shou su hui”, and analyzes the reasons for its development and change.
In the late Joseon Dynasty, there was a fever of admiration for Su Dongpo, and this fever interacted with the spread of the “Shou su hui”. After the introduction of the “Shou su hui” into the Joseon Dynasty, it further promoted the occurrence of this fever, and the Su Dongpo fever also provided sufficient soil for the development of the “Shou su hui”. As a cultural phenomenon, the “Shou su hui” connected the intellectuals of the two countries because of their admiration for Su Dongpo, and eventually became an important part of the cultural exchanges between the two countries at that time.
ANALISIS PENERIMAAN LEARNING MANAGEMENT SYSTEM AKUNTANSI TERINTEGRASI MENGGUNAKAN PENDEKATAN UTAUT YANG DIMODIFIKASI DAN TEORI DIFUSI INOVASI
Authors: Firmansyah Anggit
Published: February 2023

-Tujuan – Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor apa saja yang memengaruhi niat adopsi dari guru-guru SMK untuk mengadopsi Learning Management System (LMS) terintegrasi bernama SIDEK-Edu sebagai media mengajar di kelas yang dilihat dari sisi inovasi.Metode Penelitian – Penelitian ini menggunakan pendekatan kuantitatif. Teknik pengumpulan data dilakukan dengan memberikan kuesioner online melalui google form.Temuan – Penelitian ini menggabungkan faktor-faktor yang terdapat pada teori UTAUT, yaitu ekspektansi kinerja, ekspektansi usaha, pengaruh sosial, dan niat keperilakuan, serta faktor-faktor yang Perceived Characteristic of Innovation (PCI) yaitu kompatibilitas, ketampakan hasil, dan ketercobaan. Dari 14 hipotesis yang diajukan sebanyak 10 hipotesis diterima dan 4 hipotesis ditolak. Hasil penelitian menunjukanbahwa inovasi-inovasi yang diberikan SIDEK-Edu dapat meningkatkan kinerja dan mempermudah guru- guru SMK dalam aktivitas mengajar mereka di kelas yang kemudian meningkatan niat mereka untuk mengadopsi SIDEK-Edu. Hasil lain menunjukan bahwa niat guru-guru SMK untuk mengadopsi SIDEK-Edu didasarkan pada keputusan mereka sendiri tanpa adanya pengaruh dari lingkungan sosial.Batasan/Implikasi – Sampel yang dipilih dibatasi pada guru-guru akuntansi SMK di DIY dan Jawa Timur yang terdaftar atau mengikuti workshop terkait sosialisasi dan pelatihan SIDEK-Edu. Penelitian ini memiliki implikasi bahwa inovasi-inovasi SIDEK-Edu telah memberikan metode baru dalam praktik akuntansi yang mempermudah pembelajaran akuntansi sebagai media pembelajaran. Penggunaan SIDEK-Edu akan mendukung adanya interaksi antara pengguna dengan teknologi yang membantu untuk memberikan kesiapan menghadapi era industri 4.0.Originalitas/Nilai – SIDEK-Edu merupakan hal yang baru untuk diteliti dan merupakan LMS yangberfokus pada pembelajaran akuntansi. Model yang digunakan pada penelitian ini menunjukkan adanya hubungan baru antara variabel-variabel PCI terhadap variabel-variabel UTAUT. Hubungan tersebut, yakni variabel eksogen UTAUT memediasi hubungan antara variabel PCI terhadap niat keperilakuan. Hasil penelitian ini akan memberikan kontribusi dalam membangun teori yang berfokus pada interaksi manusia dengan teknologi.
Evaluasi Sistem Pengendalian Internal (SPI) Pengelolaan Kas: Studi pada Sheraton Mustika Yogyakarta Resort and Spa
Authors: Asmarani Prima Laksita
Published: February 2023

Tujuan Penelitian: (1) Mengevaluasi apakah sistem pengendalian internal pengelolaan kas yang diterapkan pada Sheraton Mustika Yogyakarta telah berjalan secara memadai; (2) Mengidentifikasi faktor-faktor yang menyebabkan lemahnya SPI pengelolaan kas pada Sheraton Mustika Yogyakarta; (3) Memberikan saran dan rekomendasi atas hasil evaluasi.Metode Penelitian: Penelitian ini menggunakan pendekatan kualitatif dengan desain studi kasus. Pengumpulan data dilakukan melalui kuisioner dengan menggunakan Internal Control Questionnaire (ICQ) sebagai acuan, wawancara mendalam, dan observasi atau pengamatan langsung. Setelah data terkumpul kemudian dianalisis dan dihasilkan simpulan untuk menjawab pertanyaan penelitian.Temuan: (1) Sistem pengendalian internal pengelolaan kas pada Sheraton Mustika Yogyakarta sudah memadai, namun ada hal-hal yang masih perlu diperbaiki; (2) Hal yang masih perlu diperbaiki adalah sebagai berikut: perusahaan belum memiliki jenjang karir yang jelas untuk karyawannya, struktur organisasi belum diperbarui, perusahaan belum mengklasifikasikan risiko rendah, sedang dan tinggi dan penanganannya, perusahaan belum melakukan antisipasi secara optimal terhadap perubahan model bisnis, perusahaan belum memiliki flowchart secara tertulis terkait prosedur penerimaan dan pengeluaran kas, perusahaan belum menyediakan jalur khusus untuk pengaduan (whistle blower); (3) Saran yang diberikan adalah sebagai berikut: membuat standar baku untuk jenjang karir karyawan, menetapkan struktur penanganan risiko kas sesuai dengan kriteria klasifikasi risiko dan penanganannya, membentuk flowchart baku, melakukan online marketing di media sosial, membentuk jalur khusus pengaduan (whistle blower).
ANALISIS FAKTOR YANG MEMENGARUHI KETERLAMBATAN WAKTU PENYELESAIAN TAGIHAN KEPADA NEGARA MELALUI MEKANISME KONTRAKTUAL (STUDI DI KANTOR PUSAT DITJEN PERBENDAHARAAN)
Authors: Nugroho Adhitiyo
Published: February 2023

Belanja pemerintah merupakan salah satu variabel pendukung dalam rangka mewujudkan fungsi APBN sebagai instrumen kebijakan ekonomi. Kebijakan belanja pemerintah bertujuan untuk meningkatkan multiplier effect dari setiap pengeluaran, agar APBN semakin efektif dalam memberikan stimulus perekonomian. Namun, kondisi tersebut membutuhkan adanya penyerapan belanja negara yang tepat waktu dan terjadwal. Guna menjamin hal tersebut, PMK Nomor 190/PMK.05/2012 mengatur batas waktu penyelesaian tagihan kepada negara.Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor yang memengaruhi keterlambatan waktu penyelesaian tagihan kepada negara mekanisme kontraktul pada Kantor Pusat Ditjen Perbendaharaan. Selain itu, penelitian ini juga bertujuan untuk mengidentifikasi dan menganalisis tindakan yang direncanakan oleh pengelola keuangan Kantor Pusat Ditjen Perbendaharan dalam mengatasi keterlambatan penyelesaian tagihan kepada negara. Pemilihan Kantor Pusat Ditjen Perbendaharaan sebagi objek penelitian didasarkan pada tugas Kantor Pusat Ditjen Perbendaharaan sebagai regulator dan role model dalam pelaksanaan anggaran.Penelitian ini merupakan penelitian kualitatif dengan menggunakan pendekatan studi kasus. Sumber data penelitian ini diperoleh dari wawancara mendalam terhadap pihak-pihak yang terlibat di dalam proses penyelesaian tagihan kepada negara dan data dokumentasi. Selanjutnya, sumber data tersebut dianalisis dengan menerapkan model spiral analisis Dey (1993).Hasil penelitian atas keterlambatan waktu penyelesaian tagihan kepada negara mekanisme kontraktual menghasilkan temuan sebagai berikut. Keterlambatan pengajuan hak tagih oleh pihak ketiga/rekanan kepada PPK dipengaruhi oleh ketidakdisiplinan pihak ketiga/rekanan, kelemahan kondisi internal pihak ketiga/rekanan, dan ketidaksempurnaan struktur organisasi pengelola keuangan Kantor Pusat Ditjen Perbedaharaan. Selanjutnya, keterlambatan waktu penyelesaian SPP oleh PPK dipengaruhi oleh ketidaksempurnaan struktur organisasi pengelola keuangan Kantor Pusat Ditjen Perbendaharaan, kelemahan tahap awal implementasi sistem aplikasi, dan peningkatan volume tagihan pada akhir tahun anggaran. Sementara itu, keterlambatan waktu penyelesaian SPM oleh PPSPM dipengaruhi olehiiketidakdisiplinan penerapan proses bisnis dan peningkatan volume tagihan pada akhir tahun anggaran. Berdasarkan keterlambatan proses penyelesaian tagihan kepada negara tersebut, tindakan yang direncanakan oleh pengelola keuangan Kantor Pusat Ditjen Perbendaharaan dalam mengatasi masalah tersebut ialah dengan memastikan proses penyelesaian tagihan kepada negara sesuai ketentuan PMK Nomor 190/PMK.05/2012, memperluas sistem pengendalian internal dalam proses penyelesaian tagihan negara, dan mengubah struktur organisasi pengelola keuangan Kantor Pusat Ditjen Perbendaharaan.
FAKTOR DAN DAMPAK KEBIJAKAN PEMELIHARAAN MESIN P.G MADUKISMO TAHUN 2016
Authors: Fadillah Hadyan
Published: February 2023

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang menyebabkanpemeliharaan mesin di P.G Madukismo belum optimal. Pemeliharaan mesin yang dilakukanP.G Madukismo selama 6 bulan belum dapat menekan jam berhenti mesin. Tahun 2016 jamberhenti mesin P.G Madukismo yang direncanakan sebesar 88,8 jam, namun kenyataannyajam berhenti mesin P.G Madukismo mencapai 179,44 jam selama musim giling.Penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus.Pengumpulan data dilakukan dengan wawancara, observasi dan dokumentasi. Data yangdikumpulkan kemudian dianalisis menggunakan tahap reduksi, penyajian data dan penarikankesimpula. Hasil penelitian ini menunjukkan bahwa faktor utama penyebab pemeliharaanmesin belum optimal karena umur manfaat mesin telah habis dan preventive maintenanceyang dilakukan tidak dapat mengganti seluruh komponen mesin yang mengalami kerusakanatau aus. Selain itu, P.G Madukismo juga belum memiliki SOP terkait pemeliharaan mesin.Upaya yang telah dilakukan untuk mengoptimalkan pemeliharaan mesin yaitu preventivemaintenance yang dilakukan tidak hanya diluar musim giling tetapi juga saat musim gilingdan memberikan pelatihan kepada karyawan untuk meningkatkan kemampuan karyawan.