bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of clinical practice guidelines methods to reach diagnostic test recommendations regarding diagnostic laparoscopy for endometriosis: A scoping review
Authors: Zela-Coila Frank , Quispe-Vicuña Carlos , Nuñez-Lupaca Janeth N. , Aparicio-Curazi Milagros , Goicochea-Lugo Sergio
Published: December 2024

Introduction

Although Clinical Practice Guidelines (CPG) highlight that laparoscopy is often used in the treatment of endometriosis, its diagnostic usefulness is not fully defined. Our objective was to evaluate the quality of CPGs for endometriosis that address the use of diagnostic laparoscopy in reproductive age women, and describe the recommendations and methods used to assess diagnostic test questions.

Methods

A comprehensive search of 5 databases (Trip Database, MEDLINE/PubMed, Web of Science, SCOPUS, and EMABSE) and websites of guideline development organizations and compilers was conducted from 2017 to 2023. A descriptive analysis of the recommendations was performed and the quality of the guidelines was assessed using the AGREE-II instrument.

Results

Four CPGs were included in the review, all exhibiting adequate methodological quality (scores ranging from 66.7% to 91.0%). Regarding the use of laparoscopy for endometriosis diagnosis, discrepancies in recommendations were observed. Two guidelines advised against it, one recommended either laparoscopy or medical empirical treatment, and one favored its use. GRADE guidance was employed for evidence assessment, but only one guideline transparently reported the certainty of evidence and the evidence-to-decision framework process.

Conclusions

Variability in recommendations among different CPGs were found. To keep in mind, discrepancies arise from differing prioritizations of the assessment of clinical impact in patient important outcomes and methodological approaches. This underscores the need for more standardized and transparent guideline development processes, particularly in addressing the clinical utility of diagnostic tests.
Spatial analysis of cholangiocarcinoma in Thailand from 2012 to 2021; a population-based cancer registries study
Authors: Sahat Oraya , Kamsa-ard Supot , Suwannatrai Apiporn Thinkhamrop , Lim Apiradee , Kamsa-ard Siriporn , Bilheem Surichai , Daoprasert Karnchana , Leklob Atit , Uadrang Surin , Santong Chalongpon , Sriket Nithima , Chansaard Wasan
Published: December 2024

Background

Cholangiocarcinoma (CCA) is major health issue in Thailand, with high incidences in different parts of country. This study examines the association between spatial variables and CCA in Thailand.

Methods

Thailand’s four population-based cancer registries provided data for this retrospective cohort analysis between January 1, 2012, and December 31, 2021. 6,379 diagnosed CCA cases were found in 554 sub-districts. Moran’s I and Local Indicators of Spatial Association (LISA) measured geographic dispersion and estimated sex age-standardized rates (ASRs). Multivariable log-linear regression assessed geography and CCA, calculating adjusted incidence rate ratios (IRRs) and 95% confidence interval (CI).

Results

Of 6,379 CCA cases, 63.9% were male, and the mean age at diagnosis was 66.2 years (standard deviation = 11.07 years). CCA ASRs for both sexes in Thailand was 8.9 per 100,000 person-years. The northeastern region had the greatest ASR at 13.4 per 100 000 person-years. Moran’s I and LISA studies grouped regions by spatial variables. The association between spatial variables and CCA demonstrated that the northern region exhibited elevation (adjusted IRRs = 0.82, 95%CI: 0.78 to 0.87) and distance from water sources variable (adjusted IRRs = 0.91, 95%CI: 0.82 to 0.99). The central region elevation variable (adjusted IRRs = 0.85, 95%CI: 0.76 to 0.94). This was the distance from water sources (adjusted IRRs = 0.96, 95%CI: 0.93 to 0.99) and population density variable (adjusted IRRs = 0.94, 95%CI: 0.93 to 0.96) in the northeastern region. Population density (adjusted IRRs = 1.09, 95%CI: 1.02 to 1.15) and average temperature variable (adjusted IRRs = 1.05, 95%CI: 1.02 to 1.09) were significant in the southern region.

Conclusion

Spatial variables associated with CCA indicate that ASR differs across Thailand. So environmental and climate factors can inform targeted public health strategies to address CCA in high-risk areas throughout Thailand.
Accuracy of the diagnosis of pneumonia in Canadian pediatric emergency departments: A prospective cohort study
Authors: Robinson Joan L. , Kellner James D. , Crotts Jennifer , Travassos Gabino , Chen Guanmin , Kirk Valerie G. , Pusic Martin , Reed Martin , Reid Sarah , Weinstein Michael , Bhargava Ravi , Bhatt Maala , Boutis Kathy , Curtis Sarah , Gouin Serge , Lynch Tim , van Wylick Richard , Johnson David W.
Published: December 2024

Background

The diagnosis of pediatric pneumonia and determination of the likely pathogen are complicated as the clinical picture overlaps with other respiratory illnesses, interpretation of radiographs is subjective, and laboratory results are rarely diagnostic. This study was designed to describe the relative rates of bacterial and viral pneumonia in the pediatric Emergency Department (ED), determine the accuracy of pediatric ED physicians’ ability to diagnose pneumonia and distinguish bacterial from viral etiology, and to determine clinical and laboratory predictors of bacterial pneumonia.

Methods

Children 3 months to 16 years of age presenting to seven Canadian pediatric EDs before the COVID-19 pandemic with fever and cough who had a chest radiograph performed for possible pneumonia were enrolled and underwent standardized clinical investigations. An expert panel was convened and reached a Consensus Diagnosis of typical or atypical bacterial pneumonia, viral pneumonia or not pneumonia for each case.

Results

The expert panel assessed 247 cases with the Consensus Diagnosis being typical bacterial pneumonia (N = 44(18%)), atypical bacterial pneumonia (N = 18(7%)), viral pneumonia (N = 46(19%)) and no pneumonia (N = 139(56%)). Treating ED physician diagnoses were typical bacterial pneumonia (N = 126(51%)), atypical bacterial pneumonia (N = 3(1%)), viral pneumonia (N = 10(4%)) and no pneumonia (N = 108(44%)) with low agreement between a diagnosis of bacterial pneumonia by the ED physician and the panel’s Consensus Diagnosis (Kappa 0.15 (95% CI 0.08, 0.21)). Cut off values that predicted bacterial pneumonia as the Consensus Diagnosis were ESR ≥ 47 mm/hour, CRP ≥ 42 mg/L and procalcitonin ≥0.85 ng/m. Age greater than 5 years and cough for 5 or more days also predict bacterial pneumonia.

Conclusion

In this cohort, pediatric ED physicians over-diagnosed typical bacterial pneumonia and underdiagnosed viral and atypical bacterial pneumonia. Bacterial pneumonia is most likely in children over 5 years of age, with cough for 5 or more days and/or with elevated inflammatory markers.
A novel family of beta mixture models for the differential analysis of DNA methylation data: An application to prostate cancer
Authors: Majumdar Koyel , Silva Romina , Perry Antoinette Sabrina , Watson Ronald William , Rau Andrea , Jaffrezic Florence , Murphy Thomas Brendan , Gormley Isobel Claire
Published: December 2024

Identifying differentially methylated cytosine-guanine dinucleotide (CpG) sites between benign and tumour samples can assist in understanding disease. However, differential analysis of bounded DNA methylation data often requires data transformation, reducing biological interpretability. To address this, a family of beta mixture models (BMMs) is proposed that (i) objectively infers methylation state thresholds and (ii) identifies differentially methylated CpG sites (DMCs) given untransformed, beta-valued methylation data. The BMMs achieve this through model-based clustering of CpG sites and by employing parameter constraints, facilitating application to different study settings. Inference proceeds via an expectation-maximisation algorithm, with an approximate maximization step providing tractability and computational feasibility. Performance of the BMMs is assessed through thorough simulation studies, and the BMMs are used for differential analyses of DNA methylation data from a prostate cancer study. Intuitive and biologically interpretable methylation state thresholds are inferred and DMCs are identified, including those related to genes such as GSTP1, RASSF1 and RARB, known for their role in prostate cancer development. Gene ontology analysis of the DMCs revealed significant enrichment in cancer-related pathways, demonstrating the utility of BMMs to reveal biologically relevant insights. An R package betaclust facilitates widespread use of BMMs.
Strong linkage between parrotfish functions and habitat characteristics
Authors: Randazzo-Eisemann Ángela , Molina-Hernández Ana Lilia , Alvarez-Filip Lorenzo , Garza-Pérez Joaquín Rodrigo
Published: December 2024

Phase shifts from hard coral to macroalgae have led to the formulation of a top-down herbivory paradigm, whose assumption is that a reduction in herbivory is the primary driver of these changes. Caribbean parrotfish from Scarus and Sparisoma genera are usually known as main reef herbivorous. Yet, they are a diverse group of organisms that perform multiple functions, including the bioerosion of reef structures. Generalizing functions at the group level likely explains why the direct effects of parrotfish on macroalgae regulation are not always evident. In this study, we tested the hypothesis that parrotfish potential functions are strongly linked to the habitat’s benthic characteristics. Furthermore, we expect that the parrotfish bioerosion potential will be highly sensitive to changes in benthic conditions, while herbivory will be more robust. We conducted in situ benthic and parrotfish surveys across the diverse reefscape of the remote Alacranes Reef, the most extensive system in the Gulf of Mexico. Both bioerosion and herbivory potential were highest in the most complex and structured sites, while only macroalgae removal was high in deep low-coral cover sites dominated by fleshy macroalgae. Interestingly, both functions were highly diminished in shallow and reticulated inner reefs dominated by turf algae and cyanobacteria, suggesting that even the herbivory function can be depleted under unfavorable benthic conditions. Our findings highlight the need to reconsider parrotfish management strategies to account for the specific roles of different species and consider reciprocal benthic-fish interactions.
Chemical disruption of ABA signaling overcomes high-temperature inhibition of seed germination and enhances seed priming responses
Authors: Eckhardt James , Vaidya Aditya , Cutler Sean
Published: December 2024

Seed germination is critical to agricultural productivity because low germination rates and/or asynchronous germination negatively affect stand establishment and subsequent yields. Exposure to high temperatures during seed imbibition can decrease both germination synchrony and rates through an ABA-mediated process called thermoinhibition. Methods to reduce thermoinhibition would be agriculturally valuable, particularly with increasing global mean temperatures. Lettuce seed germination is particularly sensitive to high temperatures and is a classic system for studying thermoinhibition. Extensive evidence using mutants and carotenoid biosynthetic inhibitors (e.g. fluridone) has demonstrated that endogenous abscisic acid (ABA) biosynthesis is required for thermoinhibition in lettuce and Arabidopsis. Although fluridone and related carotenoid biosynthetic inhibitors block thermoinhibition, they are not well-suited for this application due to their herbicidal effects. Here we explore the potential of ABA receptor antagonism to disrupt thermoinhibition using antabactin (ANT), a broad-spectrum high-affinity receptor antagonist. We show low μM ANT treatments (10 μM) during lettuce seed imbibition reduces thermoinhibition at temperatures of up to 40°C, demonstrating that ABA signaling is required for thermoinhibition and that receptor antagonists are well-suited anti-thermoinhibition agents. We further explored interactions between ANT and seed priming, which is used commercially to improve seed germination and reduce thermoinhibition and is achieved by partial hydration and subsequent desiccation of seeds. We show that co-priming with ANT improves germination at elevated temperatures better than priming alone, and thus, the two treatments can be combined to improve germination. Our data demonstrate that ABA antagonists are potentially useful agrochemical leads for mitigating the effects of high temperatures on seed germination and stand establishment that may be of increasing importance due to climate change. More generally, ABA antagonists should be useful in physiological processes where ABA’s effects are counterproductive to yield.
CLIP-based multimodal endorectal ultrasound enhances prediction of neoadjuvant chemoradiotherapy response in locally advanced rectal cancer
Authors: Zhang Hanchen , Yi Hang , Qin Si , Liu Xiaoyin , Liu Guangjian
Published: December 2024

Background

Forecasting the patient’s response to neoadjuvant chemoradiotherapy (nCRT) is crucial for managing locally advanced rectal cancer (LARC). This study investigates whether a predictive model using image-text features extracted from endorectal ultrasound (ERUS) via Contrastive Language-Image Pretraining (CLIP) can predict tumor regression grade (TRG) before nCRT.

Methods

A retrospective analysis of 577 LARC patients who received nCRT followed by surgery was conducted from January 2018 to December 2023. ERUS scans and TRG were used to assess nCRT response, categorizing patients into good (TRG 0) and poor (TRG 1–3) responders. Image and text features were extracted using the ResNet50+RBT3 (RN50) and ViT-B/16+RoBERTa-wwm (VB16) components of the Chinese-CLIP model. LightGBM was used for model construction and comparison. A subset of 100 patients from each responder group was used to compare the CLIP method with manual radiomics methods (logistic regression, support vector machines, and random forest). SHapley Additive exPlanations (SHAP) technique was used to analyze feature contributions.

Results

The RN50 and VB16 models achieved AUROC scores of 0.928 (95% CI: 0.90–0.96) and 0.900 (95% CI: 0.86–0.93), respectively, outperforming manual radiomics methods. SHAP analysis indicated that image features dominated the RN50 model, while both image and text features were significant in the VB16 model.

Conclusions

The CLIP-based predictive model using ERUS image-text features and LightGBM showed potential for improving personalized treatment strategies. However, this study is limited by its retrospective design and single-center data.
Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression
Authors: Grobben Marloes , Bakker Margreet , Schriek Angela I. , Levels Liesbeth J.J. , Umotoy Jeffrey C. , Tejjani Khadija , van Breemen Mariëlle J. , Lin Ryan N. , de Taeye Steven W. , Ozorowski Gabriel , Kootstra Neeltje A. , Ward Andrew B. , Kent Stephen J. , Hogarth P. Mark , Wines Bruce D. , Sanders Rogier W. , Chung Amy W. , van Gils Marit J.
Published: December 2024

HIV-1 infection leads to chronic disease requiring life-long treatment and therefore alternative therapeutics, a cure and/or a protective vaccine are needed. Antibody-mediated effector functions could have a role in the fight against HIV-1. However, the properties underlying the potential beneficial effects of antibodies during HIV-1 infection are poorly understood. To identify a specific profile of antibody features associated with delayed disease progression, we studied antibody polyfunctionality during untreated HIV-1 infection in the well-documented Amsterdam Cohort Studies. Serum samples were analyzed from untreated individuals with HIV-1 at approximately 6 months (n = 166) and 3 years (n = 382) post-seroconversion (post-SC). A Luminex antibody Fc array was used to profile 15 different Fc features for serum antibodies against 20 different HIV-1 envelope glycoprotein antigens and the resulting data was also compared with data on neutralization breadth. We found that high HIV-1 specific IgG1 levels and low IgG2 and IgG4 levels at 3 years post-SC were associated with delayed disease progression. Moreover, delayed disease progression was associated with a broad and polyfunctional antibody response. Specifically, the capacity to interact with all Fc γ receptors (FcγRs) and C1q, and in particular with FcγRIIa, correlated positively with delayed disease progression. There were strong correlations between antibody Fc features and neutralization breadth and several antibody features that were associated with delayed disease progression were also associated with the development of broad and potent antibody neutralization. In summary, we identified a strong association between broad, polyfunctional antibodies and delayed disease progression. These findings contribute new information for the fight against HIV-1, especially for new antibody-based therapy and cure strategies.
Patria y religión: el nuevo currículo para la escuela elemental del periodo franquista. Un estudio a través del análisis de cuadernos escolares de género femenino
Authors: Martín Fraile Bienvenido , Parra Nieto Gabriel , Sánchez Barbero Beatriz
Published: December 2024

Tras la Guerra Civil española, se estableció un régimen político que recuperó los conceptos de patria y religión como principios ideológicos fundamentales. Este estudio analiza si las prácticas escolares del nacionalcatolicismo, centradas en el sacrificio individual por la patria y la religión, influyeron en la identidad de género de las alumnas. Para ello, se analizaron cuadernos escolares de la escuela femenina del Centro Museo Pedagógico de la Universidad de Salamanca. Los resultados confirman que el nuevo régimen desmanteló las políticas igualitarias republicanas, relegando a las mujeres a roles subordinados y convirtiéndolas en guardianas del discurso católico y de los valores conservadores del franquismo.
Prácticas educativas de Heritage Malta: Percepción de profesionales del ámbito de la cultura maltesa
Authors: Alonso-Sanz Amparo
Published: December 2024

El patrimonio cultural de Malta está administrado por la agencia nacional Heritage Malta que se ocupa de la educación patrimonial. La presente investigación cualitativa, a través de narrativas compartidas por diferentes personas vinculadas al ámbito de la cultura en la isla, pretende recabar el tipo de prácticas que Heritage Malta desarrolla y quiénes las hacen posibles. Los resultados arrojan luz sobre las prácticas educativas actuales, las diversas posibilidades de investigación que ofrece esta institución y los eventos temporales que promueve; gracias al compromiso de personas empleadas, comisarias, artistas, y docentes con implicación en la educación patrimonial. Se concluye con algunas propuestas de mejora futura.
La innovación docente universitaria y su influencia en la museología social
Authors: Monforte García Estefanía
Published: December 2024

Este artículo se enmarca en el proyecto de recuperación “La escuela de ayer para construir el mañana” que sigue los preceptos de la museología social. En los últimos años se ha incorporado la colaboración de la Facultad de Ciencias Sociales y Humanas de Teruel con varios proyectos de innovación: las visitas del alumnado, la recopilación de memoria oral, la introducción de metodologías activas y la creación de material didáctico por parte de los futuros docentes, son algunas acciones. Todo ello aspirando constantemente a la implicación de la comunidad como motor de esta relación y del conocimiento que se genera.
El laboratorio didáctico del Museu Pedagògic de Castelló
Authors: Traver Martí Joan Andrés , Lapiedra Ortega Mark , Segarra Arnau Tomás
Published: December 2024

El Museu Pedagògic de Castelló cuenta con un fondo material de la antigua Escuela Normal de Castellón. A partir del trabajo de conservación, restauración y difusión de este fondo, planteamos la creación de un Laboratorio Didáctico vinculado a los grados de Maestro/a de Educación Infantil y Primaria. Partimos de la concepción Foucaultiana de archivo, con la idea de ofrecer una segunda oportunidad formativa a este patrimonio histórico-educativo que permita contemporaneizar los usos de estos materiales en la escuela actual. Para llevarlo a cabo implementamos tres tipos de acciones asociadas a la investigación participativa, la innovación educativa y la formación superior.
Nuove piste di ricerca sul catalogo commerciale di oggetti didattici
Authors: Pizzigoni Francesca
Published: December 2024

Il catalogo commerciale storico delle ditte produttrici di oggetti didattici rappresenta una fonte ampia e articolata che permette di approfondire numerosi aspetti della ricerca sulla storia materiale della scuola. L’articolo intende mostrare alcuni progetti in corso presso l’Università di Torino che utilizzano il catalogo di oggetti didattici sia per approfondire la conoscenza di specifiche case editrici o di specifici oggetti didattici, sia per cogliere cambiamenti più ampi all’interno dell’industria scolastica, specchio di pedagogia e didattica di un determinato periodo. In particolare l’articolo presenta un work in progress rispetto all’uso del catalogo come strumento dirimente per l’identificazione delle categorie di materiali prodotti dall’industria scolastica del passato
La grande cassettiera di Maria Montessori. La testimonianza di un pensiero in evoluzione
Authors: Gilsoul Martine
Published: December 2024

La grande cassettiera proveniente della prima Casa dei Bambini è l’oggetto principale della collezione del Museo della Scuole e dell’Educazione “Mauro Laeng” dell’Università Roma Tre per quello che riguarda il metodo Montessori. Ricostruire la biografia di questo mobile mostra l’importanza di approfondire lo studio della cultura materiale della scuola Montessori. La ricerca compiuta finora con fonti di diverse tipologie ha mostrato che si tratta probabilmente di un prototipo: ciò aiuta a comprendere l’evoluzione del pensiero di Maria Montessori per quanto riguarda l’ambiente e il significato di un arredamento che sia davvero “a misura di bambino”.
La función social del Patrimonio Universitario: Claves de la Declaración de Sevilla
Authors: Yanes Cabrera Cristina , Rodriguez Luis Méndez
Published: December 2024

El artículo se centra en analizar los antecedentes, el contexto y el objeto de la Declaración de Sevilla sobre el Patrimonio Universitario y su función social durante el I Encuentro Iberoamericano de Patrimonio Universitario. Esta declaración busca, fundamentalmente, comprometer a las universidades iberoamericanas con la protección y promoción de su patrimonio cultural, e insta a las universidades a reconocer su patrimonio cultural como una parte esencial de su misión y responsabilidad. Finalmente se plantean, a modo de conclusiones, los retos que tienen las universidades en la transformación del estudio, conservación, interpretación y exposición del patrimonio como una parte esencial de la misión y responsabilidad de nuestras universidades
Mural del poble que falta. Vicent Andrés Estellés i la literatura menor
Authors: Ribera Añó Raimon
Published: December 2024

L’obra d’Estellés és un gran encontre entre el poble i la literatura. En aquest treball ens hem fixat com a objectiu presentar una lectura de l’obra del poeta de Burjassot des d’un punt de vista polític i filosòfic que mostre detalladament la relació entre aquests dos elements. Per fer-ho s’ha recorregut als conceptes de «literatura menor» i «poble a-venir» o «poble que falta» dels filòsofs Gilles Deleuze i Félix Guattari com a ferramentes d’anàlisi textual, tractant d’identificar alguns aspectes de l’obra del poeta de Burjassot que són clau en els plantejaments polítics dels dos filòsofs. Així es volen extreure i avaluar les potencialitats polítiques de la seua obra, en particular del Mural del País Valencià, i també pensar quins elements dels allí presents podrien servir per tal d’articular un projecte polític allunyat dels interessos de les elits polítiques i al servei de les classes populars del país. Es mostra la relació que l’obra d’Estellés guarda amb els tres aspectes clau amb què Deleuze i Guattari caracteritzen la literatura menor: 1) el seu coeficient de desterritorialització, 2) la imbricació d’allò individual amb allò col·lectiu i 3) l’aparició del que anomenen «agençaments col·lectius d’enunciació»; i s’avaluen les seues conseqüències polítiques i el paper que pot tindre l’obra del poeta de Burjassot en relació amb l’articulació del poble.
La poesia de Vicent Andrés Estellés per a infants i adolescents: comentari crític des de la perspectiva de gènere i la sexualitat
Authors: Monferrer-Palmer Aina , Lacueva Lorenz Maria
Published: December 2024

Aquest estudi analiltza l’obra poètica d’Estellés destacant-hi en particular la representació de la dona i de la sexualitat, amb una atenció especial a temes com ara l’abús i les representacions sexuals explícites en els versos del poeta. A partir de la cerca de mots clau en el corpus poètic estellesià com ara penetrar, sexe, cos, cul o mamelles, i partint d’un profund coneixement de l’obra del poeta, s’hi ha identificat la presència d’insults homòfobs i de la sexualitat com a forma de dominació sempre en la mateixa direcció, entre d’altres indicis de representació heteropatriarcal tradicional. A partir de l’anàlisi, es classifica el dir estellesià segons els sis tipus de representacions de l’amor de Lee (1973) i s’hi estableixen tres arquetips femenins en la seua poesia, a més de localitzar els punts de sexualitat explícita al llarg dels poemaris de cara a l’aplicació d’Estellés a l’escola. Tenint en compte que aquesta manera de dir no és en cap cas un defecte del poeta sinó que forma part del seu context sociohistòric, és important revisar la interpretació de l’obra d’autors del cànon a la llum de l’actual sensibilitat envers la perspectiva de gènere per a posar sobre la taula quins poemaris podrien ser inapropiats per al cànon escolar o caldria tractar-los des de la recontextualització crítica. Es recomana, entre d’altres, la comparació de la veu lírica d’Estellés amb la d’altres autors i autores per a fomentar una visió crítica de la literatura entre infants i adolescents.
L’Estellés de Manel Garcia Grau: de la revisió crítica a la presència poètica
Authors: Carbó Aguilar Ferran
Published: December 2024

L’objecte d’estudi de l’article és de fer una revisió a la presència i a la influència de Vicent Andrés Estellés en la formació literària i, sobretot, en la producció escrita de Manel Garcia Grau. D’una banda, s’hi comenten els seus treballs en prosa que tracten sobre Estellés, els quals són de crítica literària i d’estudi de la literatura, i també les seues col·laboracions periodístiques. D’altra banda, s’hi estudia la incorporació i la presència del poeta de Burjassot al llarg de tota la producció poètica de l’autor castellonenc, en les dues etapes de la seua evolució. El treball constata com Garcia Grau, en descobrir Estellés, en rep la influència en els primers llibres de poemes i alhora li ret homenatge mitjançant alguns textos; també com, després, l’estudia com a crític i estudiós de la literatura aprofundint-hi en la seua poesia; i com, finalment, una vegada en coneix millor l’obra i el llegat literari, l’incorpora en nous poemes dels llibres de maduresa des de la intertextualitat i la hipertextualitat amb textos estellesians. Tot plegat permet concloure que en la primera etapa poètica de Garcia Grau incorpora i afegeix Estellés com influència literària i mostra la seua presència en alguns poemes, mitjançant citacions, epígrafs, dedicatòries, homenatge al poeta…; i, en canvi, en la segona etapa, l’aprofita, l’utilitza i l’integra literàriament en la configuració dels seus textos tenint-lo com a referent i font de préstecs, com a model textual i fins i tot hipotext per a l’elaboració dels seus hipertextos. Aquest nou aprofitament d’Estellés deriva de l’estudi i anàlisi que mentrestant Garcia Grau n’ha fet en l’aprofundiment estellesià dels seus treballs en prosa, tant en col·laboracions periodístiques, com en articles de crítica literària i d’estudi de la literatura. El jove poeta castellonenc sempre va tenir com a punt de referència l’obra del poeta de Burjassot.
Aplicació de la Intel·ligència Artificial a la recerca sociolingüística del valencià
Authors: Hernàndez Montoro Marc , Hernàndez Dobon Francesc J.
Published: December 2024

L’article presenta dues aplicacions de la Intel·ligència Artificial per a la recerca sociolingüística sobre el valencià, una realitzada amb la mineria de dades i una altra amb xarxes neuronals. S’expliquen aquestes dues funcions de la Intel·ligència Artificial i es detalla com s’ha procedit en els dos casos. Aquestes aplicacions es realitzen amb les dades depurades de les Enquestes de Coneixement i Ús del Valencià (2005, 2010, 2015 i 2021) i amb recerques pròpies fetes amb enquestes i treball de camp, i es refereixen a prediccions, expectatives de competència aliena i indicadors unitaris de competència i ús, així com índex de desigualtat lingüística. Per a la mineria de dades s’han calculat les prediccions per a 2025, de competències i usos lingüístics, el que permet fer un pronòstic de l’evolució d’un índex de desigualtat lingüística referit a les diverses regions sociolingüístiques valencianes. Aquest es fonamenta en relació al conegut Índex de Gini de desigualtat socioeconòmica, que, en el nostre cas, es calcula com a Índex de Desigaltat Lingüística amb un model de corba exponencial. S’hi aporta la fonamentació matemàtica del càlcul. En aquest punt destaquem el problema de la infravalorització de les competències lingüístiques alienes, un factor del decalatge entre competència i ús. A continuació fem una aplicació de xarxes neuronals, basades en un model d’aprenentatge. S’explica el fonament de les xarxes neuronals, el procediment per al seu ensinistrament i l’aplicació a les dades de competències i usos lingüístics de les regions sociolingüístiques del valencià. S’hi aporten les dades resultants i es presenta la interessant la correlació final entre aquell Índex de Desigualtat Lingüística i les simulacions de xarxes neuronals segons el model d’aprenentatge especificat. Aquesta conclusió és summament important, perquè permet simplificar la determinació de la desigualtat lingüística com a un càlcul de simulació de xarxes neuronals, el que obri perspectives innovadores a la recerca lingüística.
A BELEZA ESTÁ NOS OLHOS DE QUEM VÊ
Authors: Hundsdorfer Costa Pimentel Kristall , Peder Behling Hans
Published: December 2024

Objetivo: O Marketing Interno compartilha a visão estratégica da instituição com o colaborador, que atua como receptor e difusor da Imagem Organizacional, um ativo crucial no contexto atual, especialmente no contexto da prestação de serviços, como em uma universidade comunitária. Este estudo tem como objetivo analisar a relação entre a percepção do Marketing Interno e a Imagem Organizacional percebida pelos colaboradores de uma universidade comunitária.
Design / metodologia / abordagem: Duas escalas já validadas foram utilizadas para levantar os dados por meio de um questionário online respondido por 115 colaboradores técnico-administrativos e docentes do campus sede de uma universidade comunitária, em função da infraestrutura e contexto mercadológico em detrimento dos demais campi. Foram analisados utilizando a média e o desvio padrão das percepções sobre o Marketing Interno e a Imagem Organizacional da instituição, e, por meio da modelagem de equações estruturais, a relação entre os dois construtos temáticos.
Resultados: Ambos os construtos, Marketing Interno e Imagem Organizacional, receberam boas avaliações. Embora existam áreas de atenção como Imagem Afetiva, Recompensa e Comunicação Interna, a Imagem Geral, Visão e a dimensão de Treinamento e Desenvolvimento receberam avaliações excelentes, até mesmo superiores à avaliação do próprio construto original. Por fim, uma relação estatisticamente significativa entre Marketing Interno e Imagem Organizacional foi confirmada, uma contribuição importante para a teoria dos dois construtos estudados, e que oportuniza novas pesquisas explorando variáveis moderadoras ou mediadoras dessa relação.
Originalidade / valor: Esta pesquisa inova ao adaptar e relacionar duas escalas – uma tipo-Likert de 0 a 5 pontos e a outra escala de diferecial semântico de 0 a 7 pontos - já validadas, permitindo diversas análises dependendo da técnica utilizada. Além disso, relaciona dois construtos – Marketing Interno e Imagem Organizacional - amplamente explorados, mas sem evidências recentes de sua relação.
TIME-DRIVEN ACTIVITY-BASED COSTING (TDABC) EM INSTITUIÇÕES DE ENSINO SUPERIOR
Authors: De Oliveira Euzébio Dias , Pereira Eliane Nascimento , Cescon José Antonio , Lima Nilton Cesar
Published: December 2024

Dilema: A implementação de sistemas de custos em Instituições de Ensino Superior (IES) é uma tarefa complexa, que requer metodologia simplificada, em que os custos para implantação e atualização do modelo não sejam superiores aos benefícios gerados. Nesse contexto, o método de custeio TDABC surge como alternativa a ser avaliada, razão pela qual este estudo oferece uma síntese das etapas, benefícios e limitações identificadas na sua implementação em Instituições de Ensino Superior (IES).
Objetivo: Identificar procedimentos, benefícios e limitações observados na adoção do método de custeio TDABC em IES, nos estudos publicados no período de 2012 a 2022.
Metodologia: Trata-se de uma revisão sistemática da literatura, com abordagem qualitativa-descritiva, realizada nas bases DOAJ, Scopus, Congresso Brasileiro de Custos e Revista ABCustos, compreendendo o período de 2012 a 2022, nas quais foram identificados 379 documentos, dos quais, após o percurso classificatório, foram selecionados 17 artigos para síntese.
Resultados: No período investigado, observou-se o crescente interesse no método TDABC, que passou de seis estudos, em 2012 para 36, em 2022. Sua aplicação se deu nos mais diversos segmentos, com predominância de 58,87% na área de saúde. Em relação aos estudos aplicados em IES, observou-se que 47,10% foram realizados em bibliotecas. Os estudos selecionados indicaram que o TDABC, apesar do tempo necessário para o mapeamento dos processos e medição dos tempos de execução, proporciona simplicidade na implementação e auxilia os gestores na compreensão dos comportamentos dos custos, possibilitando a realização de benchmarking entre processos e a otimização do consumo dos recursos disponíveis.
Limitações/implicações da pesquisa: A utilização de apenas quatro fontes para coleta de artigos, bem como o foco em pesquisas aplicadas em Instituições de Ensino Superior, configurou-se como uma limitação deste estudo. Isso implicou na quantidade de artigos selecionados para síntese, representando somente 4,49% dos documentos inicialmente coletados, restringindo, dessa forma, o potencial alcance da investigação em relação à utilização do método TDABC no segmento educacional de forma ampla.
Originalidade/valor: O estudo se diferencia por focar na identificação dos procedimentos empregados para a implementação do método TDABC em Instituições de Ensino Superior. Além disso, fornece um panorama dos resultados obtidos a partir da aplicação do método, subsidiando a análise de viabilidade da sua adoção pelos órgãos públicos, especialmente Instituições de Ensino superior brasileiras, em momento oportuno, tendo em vista a edição da NBC TSP 34/2021.
Cutaneous Adverse Drug Reactions to Antiseizure Medications
Authors: Palafox-Romo Rebeca , Mendez-Flores Silvia
Published: December 2024

Discontinuation of antiseizure medications (ASMs), primarily prompted by adverse effects, presents a formidable challenge in the management of epilepsy, and impacting up to 25% of patients. This article thoroughly explores the clinical spectrum of cutaneous adverse drug reactions (cADRs) associated with commonly prescribed ASMs. Ranging from mild maculopapular rashes to life-threatening conditions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the diverse manifestations are meticulously detailed. Diagnostic strategies, incorporating red flags and testing methodologies, are elucidated to ensure precise identification. The classification of adverse drug reactions (ADRs), with a specific focus on cADRs and their association with type A or type B reactions, is presented. Critical risk factors, encompassing patient demographics, drug-related skin reactions, and genetic predispositions, are thoroughly explored. The article underscores the role of human leucocyte antigen (HLA), including HLA*15:02, in predicting susceptibility to severe reactions like SJS/TEN, particularly with aromatic ASMs prevalent in specific populations. Management strategies for varying cADR severities are discussed, placing emphasis on drug discontinuation, symptomatic relief, and potential desensitization. The article concludes by consolidating current knowledge, providing clinicians with a roadmap for navigating the complexities of diagnosis and management. The integration of personalized medicine principles and evidence-based approaches emerges as a crucial paradigm for the future of epilepsy management, aiming to minimize the impact of ADRs on patient outcomes.
Educación en tiempos de transformación: innovación, adaptación y desafío
Authors: Romero García Carmen
Published: December 2024

El libro está dividido en cuatro ejes temáticos: analiza experiencias de estudiantes y docentes ante la virtualidad, metodologías innovadoras, calidad educativa y colaboración internacional. De esta manera se describe el impacto de la pandemia en áreas como odontología y danza contemporánea, donde se enfrentaron retos en clases prácticas. También detalla estrategias como gamificación, aula invertida y aprendizaje híbrido; se explica su implementación en matemáticas, paleobiología y medicina veterinaria. Se centra en la calidad educativa y propone acciones para combatir la deserción académica y mejorar la eficiencia terminal. Finalmente, explora la cooperación interinstitucional, como movilidad virtual y redes globales de investigación. Enfatiza la necesidad de integrar tecnología, creatividad y metodologías activas para afrontar los desafíos de la educación superior, promoviendo una enseñanza inclusiva, ética y orientada al desarrollo de competencias para un mundo globalizado.
Abiotic stress responses in pulses: Impact of drought and high temperature
Authors: Rajmohan A , Prasad V Babu Rajendra , Senthil A , Manivannan N , Arul L , Sumathi A
Published: December 2024

Pulses, a vital food crop in India, play a significant role in nutritional security and agriculture. Despite India's prominence in global pulse production, achieving self-sufficiency in pulse production is challenged by escalating drought and rising temperatures. This review examines the responses of pulse crops to drought and high temperatures, highlighting vulnerabilities that affect seed germination, growth, biomass and reproductive traits. Drought and heat stress adversely impact seed germination, vigor and biomass accumulation while altering root and shoot characteristics. Physiological responses, including changes in photosynthesis, nutrient absorption and oxidative damage are explored alongside the implications for root nodule development under water stress. Recent molecular studies identify specific genes and proteins linked to heat tolerance in various legumes, such as green gram, wild creole bean and chickpea. The roles of microRNAs and transcription factors in modulating heat stress responses are emphasized. Additionally, heat stress-induced differential gene expression in cowpea nodules and soybeans impacts flowering pathways and key regulatory genes. Understanding these complex interactions between environmental stressors and pulse crop physiology is crucial for developing resilient varieties and sustainable agricultural practices amid climate change-induced challenges. Future research should focus on elucidating the molecular mechanisms of drought and heat tolerance, particularly stress-responsive genes, transcription factors and microRNAs. Advances in gene editing and genomics will aid in creating resilient pulse varieties, while comparative studies can refine breeding strategies to enhance drought and heat tolerance, ultimately supporting sustainable pulse production.
Determinants of climate-smart agricultural technology adoption: A comprehensive systematic review
Authors: Dhivya C , Murugan P P , Senthilkumar M , Asokhan M , Dheebakaran Ga , Gangai Selvi R , Arunkumar R
Published: December 2024

Climate-Smart Agricultural (CSA) technologies are essential in enhancing agricultural sustainability and resilience in the face of climate change. However, the successful adoption of these technologies remains a complex challenge influenced by various factors. This research aims to provide a systematic review of the factors affecting the adoption of CSA technologies and thoroughly examine academic research in this rapidly developing study area. Scientific mapping was conducted, analytical techniques were used to understand the annual scientific production countries with the highest citations and co-occurrence network analysis was also done using the key search terms of CSA adoption research. The literature on determinants of CSA adoption is synthesized in terms of theories, contexts, characteristics and methods (TCCM) framework to propose future research directions.Additionally, the study develops a conceptual framework incorporating the commonly mentioned antecedents, mediators, moderators and consequences in existing literature. Drawing upon an extensive review of peer-reviewed articles, this study categorizes factors into 3 main dimensions: Socio-Demographic and Socioeconomic factors, Farm and Land factors and Technological and Informational factors. This review of the research also reveals the impact of positive and negative aspects onCSA's adoption. In addition, this review summarizes the theoretical perspectives taken in this field of study. Furthermore, to develop this research domain, some interesting future research directions have been recommended by identifying understudied research areas.
Exploring termiticidal properties and GC/MS-based chemical profile of Lantana camara (L.)
Authors: Gundakanal Devindra , Premalatha K , Murugan M , Shanmugam PS , Harish S , Uma D
Published: December 2024

India accounts for almost 10 % of the worlds' termite species. Odontotermes horni is one of the most important termites, posing significant threats to agricultural and horticultural ecosystems. The persistent nature of synthetic termiticides necessitates the development of alternative control strategies. The present study investigates the phytochemical composition and potential termiticidal and acetylcholinesterase (AChE) inhibitory properties of Lantana camara (L.) leaf against O. horni. Methanolic, ethyl acetate, and aqueous extracts of L. camara (L.) leaves were used to assess their toxicity. The methanolic extract exhibited the highest potency, with an LC50 of 0.98%, followed by ethyl acetate (1.40 %) and water extract (8.81 %). The per cent mortality recorded at 2.5 % concentration for methanol, ethyl acetate, and aqueous extract was 96.20, 78.75 and 21.25, respectively. By fumigant action, the L. camara (L.) leaf extract at a 5% concentration of methanol, ethyl acetate and aqueous extract resulted in 68.75, 42.50 and 26.25 percent mortality, respectively. The methanolic extract showed the highest AChE inhibition (52.39 %), followed by the ethyl acetate (47.00 %) and the aqueous (43.53 %) extracts after 24 hours of exposure. GC-MS analysis of plant volatiles of the L. camara (L.) revealed 196 compounds, including terpenoids, known for termiticidal activity.
Optimizing cotton production through efficient weed management using herbicides: A promising solution for labour-scarce farming
Authors: Sanjaykumar T , Nageswari R , Somasundaram S , Anantharaju P , Baskar M , Subrahmaniyan K
Published: December 2024

Cotton, often referred to as ‘White gold’ and the ‘King of fibre crops’ holds a significant position as a cash and fibre crop in India. Weeds contribute to approximately 45 % yield reduction in cotton cultivation at the national lev?el, making weed management a critical factor in determining cotton productivity, particularly in high-density planting systems (HDPS). Effective weed control optimizes resource allocation, leading to improved growth parameters and higher yields. This study investigates the efficacy of various weed management practices, including pre-emergence and post-emergent herbicide applications, in enhancing cotton yield under HDPS. The results clearly demonstrate that a combination of PE Pendimethalin (1.0 kg a.i./ha), Metolachlor (1.0 kg a.i./ha), POE Pyrithiobac sodium (0.075 kg a.i./ha), and Quizalofop ethyl (0.075 kg a.i./ha) led to significantly greater plant height (113.4 cm) and dry matter production (7609 kg ha-1 ) . This treatment also resulted insignificantly improved yield parameters, with a higher seed cotton yield of 2098 kg ha-1 , and yielded higher net returns of Rs.141961 ha-1 and a Benefit Cost Ratio (BCR) of 3.09. In the face of increasing labour scarcity, these herbicide-based weed management practices offer a viable solution for maximizing cotton productivity under HDPS. This approach supports the rapid expansion of cotton acreage in the current era of farm mechanization.
Unravelling the role of Black Soldier Fly Frass (BSFF) in nutrient enrichment and growth promotion of groundnut (Arachis hypogaea L.)
Authors: Raman S , Srinivasan G , Shanthi M , Saravanan S , Mini ML
Published: December 2024

The decomposition of organic waste by Black Soldier Fly (BSF) plays a potential role in plant growth promotion and soil nutrient enrichment. This study investigated the effect of different compost from food waste, vegetable & fruit waste, cow manure, pig manure, poultry manure, TNPL (Tamil Nadu Newsprint and Papers Limited) bio sludge and combinations of these materials induced varied growth promotion on groundnut. A pot culture experiment evaluated shoot length, root length, germination percentage, plant biomass and vigour index. The best results were observed in the treatment combining hostel food waste and vegetable waste (50 %) with poultry manure (50 %) (T7), showing a shoot length of 20.34 cm, vigour index of 3629, plant biomass of 24.3 g, and germination percentage of 93.33%. Other treatments, such as food waste (T1) and vegetable and fruit waste (T2), showed vigour indices of 2561.6 and 2692.9, respectively, while the untreated control had the lowest vigour index of 900.4. Nutrient analysis of T7 compost revealed high levels of nitrogen (462 kg/ha), phosphorus (375 kg/ha), potassium (320 kg/ha) and micronutrients like iron (29.04 ppm) and zinc (7.58 ppm). GC-MS analysis identified growth-promoting compounds like Cyclohexanol (64.3 %), Glycerol (3.9 %) and Dibutyl phthalate (1.49 %). Metabolite set enrichment analysis (MSEA) highlighted pathways like fatty acid biosynthesis and glycerolipid metabolism, which support root development and stress tolerance. The results indicated that BSF compost, especially from food and vegetable waste with poultry manure, significantly enhances soil fertility and plant growth, providing a sustainable solution for organic waste management.
Morfologia plagiatu
Authors: Hendrykowski Marek
Published: December 2024

Authorship, as a protected good, is never entirely secure. Plagiarism is a practice that has been perpetually present in human culture. This monographic essay dedicated to plagiarism offers a broad, panoramic view of its occurrence in science, art, and other creative fields. The author posits that the true subject of plagiarism is not the substance of the plagiarized text (words, sounds, images), but its essence, namely the original authorial thought – the original concept, idea, or creative vision contained within the structure of the original work.