bluuebunny/crossref_metadata_2025 huggingface dataset:
Irrigation Frequency and System Affect Poinsettia Growth, Water Use, and Runoff
Authors: Morvant Jaime K. , Dole John M. , Cole Janet C.
Published: October 2024

Euphorbia pulcherrima Willd. Ex. Klotzsch `Gutbier V-14 Glory' plants were grown with N at 220 mg·L-1 (20N-4.4P-16.6K) using hand (HD), microtube (MT), ebb-and-flow (EF), and capillary mat (CM) irrigation systems and were irrigated either daily (daily = D) or as needed (intermittent = I). For all irrigation systems, daily irrigation produced plants with the greatest total dry mass and reduced the amount of nutrients lost as runoff, but plant quality was reduced in one of two years due to excessive, weak growth. Plants irrigated by MT-D and EF-D had the greatest total dry masses. HD produced lower total plant dry mass than all other irrigation systems and frequencies. Runoff from MT-D and EF-D treatments had the lowest concentration of NO3-N, NH4-N, and PO4-P. The MT-D, EF-D, and EF-I treatments were the most water-efficient, whereas the CM system had the lowest water efficiency and used the greatest amount of water. Daily irrigation with the MT or EF systems produced optimum plant growth, but intermittent MT irrigation was more water-efficient. Daily irrigation is a viable production system, but only where water conservation is not a concern.
Plant Spacing Affects Yield of `Superstar' Muskmelon
Authors: Maynard Elizabeth T. , Scott W. Dennis
Published: October 2024

Field studies were conducted in northern and southern Indiana in 1993 and 1994 to determine optimal plant spacings for muskmelon (Cucumis melo L. var. reticulatis cv. Superstar) production. Yield and number of fruit per hectare generally increased as plant population increased from 3074 to 10,764 plants/ha. Number of fruit per hectare increased linearly as in-row spacing decreased from 1.5 to 0.6 m in five of six experiments. Early yield, as percentage of total yield, also increased linearly as in-row spacing decreased in 1993 in southern and in 1994 in northern Indiana. The number of fruit harvested per plant and average fruit mass decreased linearly as in-row spacing decreased. Between-row spacing (1.5 vs. 2.1 m) did not affect fruit number per plant or average fruit mass.
Growth, Nitrogen Accumulation, and Weed Suppression by Fall Cover Crops Following Early Harvest of Vegetables
Authors: Stivers-Young Lydia
Published: October 2024

Oats (Avena sativa L.), phacelia (Phacelia tanacetifolia Benth.), oilseed radish (Raphanus sativus L.), white senf mustard (Brassica hirta Moench), kale (Brassica oleracea L.), canola (Brassica napus L.), turnip (Brassica rapa L.), and yellow mustard (Brassica hirta Moench) were evaluated for their ability to grow, accumulate leachable N, and suppress winter annual weeds during the fall following early harvest of vegetables in the northeastern United States. Brassica and phacelia cover crops planted in late August and early September produced 3000-4000 kg·ha-1 in aboveground biomass, and took up 100-120 kg·ha-1 soil N before winter killing in December. Soil inorganic N decreased in all plots through the fall of both years but concentrations in cover crop plots tended to be lower than in bare plots. Analysis of soil surface residues the following April showed that brassicas had lost a greater proportion of aboveground biomass and N during the winter than had oats in 2 years of study. How much of the loss of biomass was due to residue decomposition at the soil surface and how much was due to wind or other off-site losses is not clear. Soil inorganic N concentrations in cover crop plots tended to be higher than in bare plots the following April. Cover crop residues significantly suppressed weed growth in early spring; in several treatments, no measurable weed growth was found in the second year. These results indicate that oilseed radish, white senf mustard, and yellow mustard are well suited for use as fall cover crops in the temperate northeastern United States, but that significant biomass and N may be lost if they are left to winter kill.
Integrating Biological Control and Calcium Treatment for Controlling Postharvest Decay of Apples
Authors: Janisiewicz Wojciech J. , Conway William S. , Glenn D. Michael , Sams Carl E.
Published: October 2024

Two nonfungicidal postharvest treatments and N fertility were evaluated for their effectiveness, singly and in combination, in controlling decay (“blue mold”) of apple (Malus ×domestica Borkh.) by Penicillium expansum Link. The antifungal treatments were biological control using the antagonist Pseudomonas syringae van Hall (isolate ESC-11 used in BioSave-11 and BioSave-110 products), and pressure infiltration of fruit with 0.27 M CaCl2. Fruit susceptibility to decay was evaluated using fruit after 3 and 6 months of storage over 2 years. Calcium infiltration resulted in a 3-fold increase in Ca content of apple mesocarp. Both antagonist and Ca treatments reduced the severity and incidence of blue mold decay on `Delicious' apples. Combining these treatments resulted in greater control than the individual treatments alone. The effects were most apparent on fruit stored 6 months at 1 °C. High N fertilization increased decay in only 1 of 2 years of the study. Antagonist recovery data suggest that the antagonist could be applied immediately after Ca treatment. Combining a biocontrol agent with Ca infiltration may allow reduced rates of both products to be used without compromising the control of blue mold. This practice will increase the performance margin for biocontrol with the added benefit of increased Ca to alleviate physiological storage maladies.
Disorders in `Cortland' Apple Fruit Are Induced by Storage at 0 °C in Controlled Atmosphere
Authors: DeEll Jennifer R. , Prange Robert K.
Published: October 2024

The effects of low temperature in controlled-atmosphere storage on five strains of `Cortland' apples (Malus ×domestica Borkh.) grown in Nova Scotia were investigated. The apples were held in either standard controlled-atmosphere (2.5 kPa O2 and 4.5 kPa CO2) or low-oxygen (1.5 kPa O2 and 1.5 kPa CO2) storage at 0 or 3 °C for 4 and 8 months. The results indicated that `Cortland' apples are sensitive to low temperature, but not to low oxygen or high CO2. Low temperature (0 vs. 3 °C) caused an increase in low-temperature breakdown, core browning, and vascular breakdown, while having no significant effect on fruit firmness, soluble solids concentration (SSC), titratable acidity, loss of mass, or superficial scald development. Low oxygen (1.5 vs. 2.5 kPa) or high CO2 (4.5 vs. 1.5 kPa) in the storage atmosphere had no significant effect on fruit firmness, SSC, titratable acidity, loss of mass, or the incidence of storage disorders.
Reaction of Select Tepary Bean to Ashy Stem Blight and Fusarium Wilt
Authors: Miklas Phillip N. , Schwartz Howard F. , Salgado Marcelo O. , Nina Ramon , Beaver James S.
Published: October 2024

Cultivated tepary bean (Phaseolus acutifolius A. Gray var. latifolius Freeman) has received considerable interest as a crop for dryland production regions around the world. Successful tepary bean production will depend partly upon its resistance to endemic diseases. Thirteen select tepary bean lines were evaluated in the field and by rice-seed inoculation for resistance to ashy stem blight [Macrophomina phaseolina (Tassi) Goid.] and by a root-clip inoculation method for resistance to fusarium wilt [Fusarium oxysporum Schlechtend.:Fr. f. sp. phaseoli J.B. Kendrick and W.C. Synder) (Fop)]. Three lines, Mex-114, PI 440806-s, and PI 321637-s, exhibited high levels of resistance to both pathogens and their diseases. These reactions, combined with known resistances to other pathogens, will allow identification of multiple-disease-resistant tepary bean germplasm for use in different production regions and breeding programs.
Pollen Nuclear Number in Four Diospyros Species
Authors: Sugiura Akira , Tao Ryutaro , Ohkuma Takeshi , Tamura Mihoko
Published: October 2024

The pollen nuclear number of Diospyros kaki, D. virginiana, D. rhombifolia, and D. lotus was investigated by fluorescence microscopy and flow cytometry. Contrary to Brewbaker's description (1967) that Diospyros species possess binucleate pollen, our examinations revealed that four Diospyros species are unusual in that they have trinucleate pollen.
Inhibitors of Ethylene Action Affect Final Quality and Rooting of Cuttings before and after Storage
Authors: Serek Margrethe , Prabucki Adam , Sisler Edward C. , Andersen Arne S.
Published: October 2024

Vegetative cuttings of three species, Dendranthema grandiflorum (Ramat.) Kitamura, Pelargonium zonale L., and Hibiscus rosa-sinensis L., were treated with 1-MCP or STS to determine the effect of inhibition of the action of ethylene on quality and rooting ability both without and with storage. Storage decreased quality of Pelargonium and Hibiscus cuttings, causing leaf yellowing and chlorophyll degradation. No leaf yellowing was detected in Dendranthema cuttings, regardless of treatment. Storage inhibited rooting of the cuttings, particularly in Pelargonium, where rooting was halved. Chemical inhibition of ethylene action retarded storage-induced leaf yellowing, but also reduced rooting ability both in fresh and stored cuttings. Chemical names used: 1-methylcyclopropene (1-MCP); silver thiosulfate (STS).
Correlations between the structural and impurity features revealing fluctuant growth conditions of natural fibrous diamonds
Authors: Sun Chengyang , He Mingyue , Lu Taijin , Muraishi Shinji , Deng Yi
Published: October 2024

Fibrous diamonds containing numerous mantle fluid inclusions have been studied to explore their unique growth patterns and the evolution of mantle fluids. However, the growth of fibrous diamonds is not a completely homogeneous process, and there has been limited focus on the growth fluctuations of the diamonds themselves. This gap in research hinders our understanding of mantle fluid evolution. To address this issue, polarizing microscope, energy dispersive spectroscopy (EDS), cathodoluminescence (CL), Raman spectroscopy, and Fourier-transform infrared spectroscopy (FTIR) were used to make systematic studies about the distribution and composition of fluid micro-inclusions, growth structure, plastic deformation, residual stress, and impurities in coated diamonds from the Democratic Republic of the Congo (DRC). It was found that VN3H defects controlled the luminescence of diamond growth layers, and plastic deformation and residual stress were mainly related to nitrogen content. However, the relationship between VN3H defects and nitrogen content in the core varied, leading to contrasting correlations with plastic deformation and residual stress. In the fibrous coat existed growth layers with varying densities of micro-inclusions. Interestingly, both the dark fibrous layers with the highest density of micro-inclusions and the light-yellow fibrous layers with the lowest density of micro-inclusions showed positive anomalies of plastic deformation, tensile residual stress, nitrogen concentration, and VN3H defects. According to the micro-inclusion composition and the effect of growth conditions on the growth rate and impurity incorporation of diamonds. It was speculated growth mediums with high water contents led to the formation of dark layers with the highest growth rate, and reduced growth pressures were the major reason causing the crystallization of light-yellow fibrous layers. This study evidenced that the nucleation of natural fibrous diamonds could be subjected to the influence of multiple factors, which furthered our cognition about the growth process of natural fibrous diamonds, and also exemplified that the systematic correlations between the structural and impurity features of diamonds have the potential to reflect variations of mantle conditions under which they crystallized.
Supersymmetric polynomials and algebro-combinatorial duality
Authors: Galakhov Dmitry , Morozov Alexei , Tselousov Nikita
Published: October 2024

In this note we develop a systematic combinatorial definition for constructed earlier supersymmetric polynomial families. These polynomial families generalize canonical Schur, Jack and Macdonald families so that the new polynomials depend on odd Grassmann variables as well. Members of these families are labeled by respective modifications of Young diagrams. We show that the super-Macdonald polynomials form a representation of a super-algebra analog \mathsf{T}(\widehat{\mathfrak{gl}}_{1|1})𝖳(𝔤𝔩̂1|1) of Ding-Iohara-Miki (quantum toroidal) algebra, emerging as a BPS algebra of D-branes on a conifold. A supersymmetric modification for Young tableaux and Kostka numbers are also discussed.
Formas de Tratamento Otimizado e Humanizado em Crianças com Transtorno do Espectro Autista e o Desafio no atendimento Odontológico
Authors: Mendonça Márcia do Socorro dos Santos Batista
Published: October 2024

O atendimento odontológico em crianças com transtorno do espectro autista (TEA) se destaca pela necessidade de ações capazes de oferecer um tratamento otimizado e humanizado. O presente estudo fornece diretrizes e orientações aos profissionais de odontologia, visando aprimorar a qualidade do atendimento oferecido e promover o bem-estar das crianças com TEA, com a aplicação de técnicas comportamentais pelo profissional dentista apropriadas a auxiliar na prestação do serviço e que evite situações que possam incidir danos físicos e psicológicos aos pacientes ou familiares. A experiência mostra que muitas crianças com TEA enfrentam dificuldades em receber atendimento odontológico adequado tanto por sua sensibilidade quanto pela dificuldade de comunicação, sendo um problema que ocorre em consultórios particulares e nos serviços de saúde pública. Diante disso, o objetivo deste estudo é apresentar as formas de tratamento que visem otimizar e humanizar o atendimento odontológico e descrever as técnicas utilizadas direcionadas para pacientes autistas. Os resultados encontrados evidenciam a importância de um tratamento que considere as necessidades específicas das crianças com esse perfil, que inclui o uso de estratégias de comunicação alternativa, empregando imagens e pictogramas, adaptação do ambiente odontológico de forma a torná-lo mais acolhedor, treinamento dos profissionais dentistas para receber esse público e familiarização prévia do paciente para que uma relação de confiança seja estabelecida e proporcionar um tratamento efetivo. Em conclusão, trata-se de um tema relevante para uma sociedade cada vez mais inclusiva, que visa garantir acesso igualitário ao atendimento odontológico para todas as crianças, que independa de suas habilidades de comunicação e sensibilidades.
MANAGING LEARNERS BEHAVIOUR: A CALL ON TEACHERSUSE OF POSITIVE MODIFICATION STRATEGIES
Authors:   Department of Education, Enchi College of Education., Kwaw Nsiah Regine , Edjah Kaowo ,   Department of Education and Psychology University of Cape Coast.
Published: October 2024

This study explored into teachers use of positive modification approachesin managing learners classroom behaviour. This was a descriptive survey design (qualitative)that employeda 5-point Likert-type scale for data collection. Respondents comprised of 327 pubic Junior High School teachers in the Western North region. A multi-stage sampling procedure was used for the selection of samples. Data were analysed using descriptive and inferential statistics. Data from the study showed that majority of teachers had inadequate knowledge on using positive modification strategies in managing learners behaviour.Tangible strategies such as earning of incentives like toffee and rewards emerged as the most frequently used behaviour modification strategies in managing the classroom.The study also found no significant gender difference with regard to the use of positive modification strategies in classroom management. The study further established that behaviour modification techniques positively influences the learning environment as well as the learner.It was recommended that teachers unions in collaboration with Ghana Education Service should organize sensitisation programs through educational fora and symposiums to encourage teachers embrace positive modification strategies as classroom management tools. Also, intermittent refresher coursesought to be organized to help educatorsupdate their knowledge on the use of positive modification strategies in managing learners behaviour. This possibly will aidthem to effectively manage learners behaviour in the classroom.
Doğa Turizminde Yeni Eğilim: Modern Kampçılık
Authors: Gürer Burak
Published: October 2024

Doğada zaman geçirmek birçok amaçla kullanılan bir etkinlik hâline dönüşmüştür. Kişisel gelişim, heyecan arama, rehabilitasyon, eğitim yapmak ve dinlenmek gibi nedenler sebebi ile doğa sınırsız imkânlar sunmaktadır. Açık alan etkinliklerinin bu özelliği son yıllarda doğa turizminin çeşitlenmesine neden olmuştur. Kampçılık yapanlar doğanın sunduğu bu eşsiz güzellikleri görmek adına büyük çabalar harcamaya başlamış ve giderek donanımlarını arttırmaya başlamışlardır. İzole bölgelere ulaşmadaki zorluk ve mesafe araç kullanmak isteyen kampçı sayısında belirli bir artışa neden olmuştur. Böylelikle, doğa turizmi içinde yer alan kampçılık, son zamanlarda hızlı bir gelişim içinde olmakla birlikte farklı eğilimler içine girmiştir. Özellikle Covid-19 pandemisi sonrası insanların kapalı ve kalabalık ortamlardan ayrılma isteği artmış ve bunun sonucunda doğada zaman geçirmeye başlamışlardır. Bu da doğa turizminin bir parçası olan kampçılığa hareketlilik kazandırmıştır. Karavan ve kamp araçlarının yaygınlaşması sonucunda yeni bir eğilim olarak adlandırabilen araçlı kampçılık oldukça belirgin bir hâle gelmiştir. Bununla beraber çadır, karavan ve araç üstü çadır kampçılığı aynı zamanda çevresel sorunlara da yol açmaya başlamıştır. Bu çalışmada, son yıllarda büyük ivme kazanan kampçılık çeşitleri ve ortaya çıkardığı sorunlar derlenmeye çalışılmıştır. Sonuçların kamp, karavan ve kamp aracı ile yapılan kampçılıkta doğanın korunması ve çevre kirliliğinin engellenmesi adına etkili olacağı çalışmaya temel oluşturmuştur. Özel ve kamu işletmelerine ve gelecekte yapacakları kamp alanları için bir rehber olacağı düşünülmüştür. Elde verilere göre, eğitimsiz ve bilinçsiz şekilde yapılan kampçılık ciddi şekilde kirlilik sebebidir. Doğanın korunması için yerel yönetimlere düşen sorumluluklar oldukça önemlidir.
Optimizing urban flood management: enhancing urban drainage system efficiency under extreme rainfall events
Authors: Ma Tianfang , Kim Jong-Suk , Jun Changhyun , Moon Young-Il , Moon Hyeontae
Published: October 2024

Extreme rainfall events, particularly those induced by tropical cyclones, pose a heightened risk to the urban drainage system (UDS). Existing UDSs, having been established long ago, often fail to account for the extreme rainfall caused by cyclones. To address this issue, this study designs a multi-objective intelligent scheduling model within a simulation -optimization framework, aiming to optimize the operation of urban drainage infrastructure and hydraulic structures. This is achieved by integrating the Storm Water Management Model (SWMM) with the multi-objective particle swarm optimization algorithm (MOPSO) and distinctly evaluating typhoons and torrential rains for their impact on extreme rainfall. The study results show that the multi-objective intelligent scheduling model can effectively devise operation strategies for pumping stations and weirs in the study area, thereby optimizing their use for urban drainage. The model was successful in reducing the total flood volume (TFV) and the water level fluctuation (WLF) by 3.11%–57.77% and 26.32%–65.48%, respectively. This not only mitigates urban flooding but also enhances the infrastructure stability of the UDS. The model outperformed the local adaptation strategy in most scenarios for the two selected objectives, suggesting that the efficiency can be significantly improved by optimizing UDSs without expansion of existing infrastructure or additional costs.
Ecological scheduling model of the Wujiang River cascaded hydropower reservoirs based on improving the DE algorithm
Authors: Zhu Xi , Mo Hejian , Wu Shanfeng , Wang Rongrong , Zhang Jin
Published: October 2024

To protect the aquatic ecological system of the Wujiang River, ecological scheduling is carried out for the cascaded hydropower reservoirs along the river. This aims to achieve a win-win situation by minimizing the negative impact on the ecological environment while harnessing the economic benefits of the cascaded hydropower reservoirs. First, to address the slow convergence and susceptibility to local optima issues of the differential evolution algorithm, a new methodology was developed: a differential evolution algorithm with chaotic opposition-based initialization (COI) and average mutation update-based strategy (AMU). Second, an optimization model for the cascaded hydropower reservoir's ecological scheduling was constructed, dividing it into two modes: the daily average control mode and the instantaneous control mode. The Wujiang River cascaded hydropower reservoir's ecological scheduling optimization model was solved using the proposed differential evolution algorithm with COI and AMU. The results indicate that the proposed algorithm exhibits superior optimization capabilities and is more suitable for solving the cascaded hydropower reservoir's ecological scheduling optimization model. Studies demonstrate that adopting different ecological scheduling control modes for the Wujiang River cascaded hydropower reservoirs not only ensures power generation benefits but also enhances the ecological benefits of the Wujiang River cascade hydropower reservoirs.
Olaparib: A Chemosensitizer for the Treatment of Glioblastoma
Authors: Dhanavath Naresh , Bisht Priya , Jamadade Mohini Santosh , Murti Krishna , Wal Pranay , Kumar Nitesh
Published: October 2024

Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor. The current
treatment for GBM includes adjuvant chemotherapy with temozolomide (TMZ), radiation therapy,
and surgical tumor excision. There is still an issue because 50% of patients with GBM who get
TMZ have low survival rates due to TMZ resistance. The activation of several DNA repair mechanisms,
such as Base Excision Repair (BER), DNA Mismatch Repair (MMR), and O-6-
Methylguanine-DNA Methyltransferase (MGMT), is the main mechanism via which TMZ resistance
develops. The zinc-finger DNA-binding enzyme poly (ADP-ribose) polymerase-1
(PARP1), which is activated by binding to DNA breaks, affects the activation of the MGMT, BER,
and MMR pathway deficiency, which results in TMZ resistance in GBM. PARP inhibitors have
been studied recently as sensitizing medications to increase TMZ potency. The first member of the
PARP inhibitor family to be identified was Olaparib. It inhibits PARP1 and PARP2, which causes
apoptosis in cancer cells and DNA strand break. Olaparib is currently investigated as a radio- and/or
chemo-sensitizer in addition to being used as a single agent because it may increase the cytotoxic
effects of other treatments. This review addresses Olaparib and its significance in treating TMZ resistance
in GBM.
Development And Validation of In-Vitro Release Test (IVRT) Method for Topical Complex Generic - Ganciclovir Ophthalmic Gel
Authors: Dhudashia Komal Rajendrakumar , Patel Nilesh K.
Published: October 2024

Background:

The in-vitro release test (IVRT) is a tool to measure the amount and
the release rate of active pharmaceutical compounds released from topical semisolid dosage
forms. The IVRT provides significant information for product performance assessment and
evaluation. It is also used to assess the bioequivalence study (biowaivers) for topical semisolid
products.

Objective:

The study aims to develop and validate the IVRT method for qualitative and quantitative
estimation of ganciclovir topical products and to demonstrate the similarity between the
marketed reference product and the in-house test product of ganciclovir ophthalmic gel.

Methods:

The method was developed using a vertical diffusion cell with a synthetic cellulose
membrane, simulated tear fluid as the receiver media, and UV detection. The IVRT study was
performed at 100rpm and 32oC for 6hr. The marketed formulation containing 0.15%w/w
ganciclovir was used as a reference.

Results:

The in-house test product of ganciclovir met all characterization criteria. The analytical
method was optimized and validated with a concentration range of 2-14μg/ml and a regression
coefficient of 0.9997 as per the ICH guideline. The developed IVRT method was simple,
economical, linear, robust, reproducible, sensitive, specific, and selective to evaluate the drug
release from the formulation. The %recovery at 6hr was found to be 84.43% and 78.68% for
reference and test product of ganciclovir ophthalmic gel with correlation coefficient R2 0.9947
and 0.9921, respectively, this value justified the biowaivers between the reference and test formulation.

Conclusion:

This method can be utilized to check topical semisolid product quality, product
performance, and product uniformity. Additionally, it can also be used to waive the requirement
for bioequivalency studies for ganciclovir ophthalmic gel.
Yinxieling Inhibits Keratin 17 to Enhance Mitochondrial Function and Ameliorates Psoriasis-like Lesions
Authors: Wang Shilei , Pan Helin , Zhao Chenxi , Chen Wanqun , Zhang Jinwei
Published: October 2024

aims:

To study investigates the mechanism of action of Yinxieling in the treatment of psoriasis.

background:

Psoriasis is a chronic skin disease characterized by erythema, scaling, and thickening. Yinxieling is a representative prescription for treating psoriasis developed by Professor Guowei Xuan, a master of traditional Chinese medicine. Keratin 17 is a key biomarker for the diagnosis and treatment of psoriasis, and its overexpression has been shown to impair mitochondrial function.

objective:

To study investigates the mechanism of action of Yinxieling in the treatment of psoriasis.

method:

In vivo, BALB/c mice were induced by imiquimod to create psoriasis-like mice model. Different doses of Yinxieling were administered to the psoriasis-like mice and PASI scores, thickness of epidermis and Keratin 17 expression of psoriasis-like mice were measured. In vitro, HaCaT cells were induced by IL-17A, IL-22 and TNF-alpha to establish psoriasis-like cells model. Yinxieling with different concentrations were administered to the psoriasis-like cells and Keratin 17 expression, adenosine triphosphate levels and oxygen consumption rates were measured. Furthermore, the psoriasis-like cells were transfected with keratin 17 plasmids. Yinxieling intervened in these psoriasis-like cells with continuous high expression of keratin 17 and adenosine triphosphate levels and oxygen consumption rates were measured.

result:

Yinxieling significantly improved PASI scores and decreased their epidermal thickness in psoriasis-like mice; Yinxieling also inhibited Krt17 expression in psoriasis-like mice and cells. Yinxieling improved ATP levels and oxygen consumption rate in psoriasis-like cells, and this effect of Yinxieling was abolished when the psoriasis-like cells were transfected with keratin 17 plasmids.

conclusion:

Yinxieling inhibits keratin 17 to enhance mitochondrial function and ameliorates psoriasis-like lesions.

other:

None
ANALISIS PERAN PEMERINTAH DALAM PENGENDALIAN TINGKAT PENGANGGURAN TERBUKA DI JAWA TIMUR PASCA COVID-19
Authors: Alkhatiri Zein Syakhur , Santoso Dwi Budi
Published: October 2024

The post-COVID-19 open unemployment rate (TPT) tends to rise sharply. In this case, the role of the government needs to be focused on The government's role can be reflected through three main mechanisms to keep the open unemployment rate down mechanisms in keeping the TPT down, namely setting the minimum wage, stimulating economic growth, and population control. economic growth, and population control. This study aims to determine the impact of the government's role in controlling the open unemployment rate in East Java. open unemployment in East Java. This study uses secondary data in the form of panel data, with a time span of 2017-2022 and covering 38 districts/cities in East Java. districts/cities in East Java. The analysis method used is the panel data method. panel data method. The results show that the minimum wage contributes to increase in unemployment, economic growth can reduce unemployment, while population control also reduces unemployment rate. Therefore, the government needs to consider the positive and negative impacts of the three instruments to achieve an optimal effect.
Web application performance assessment: A study of responsiveness, throughput, and scalability
Authors:   Faculty of Computer Studies, Arab Open University, Riyadh, Saudi Arabia, Alnuhait Hend , Alzyadat Wael ,   Faculty of Sciences and Information Technology, Al-Zaytoonah University of Jordan, Amman, Jordan, Althunibat Ahmad ,   Faculty of Sciences and Information Technology, Al-Zaytoonah University of Jordan, Amman, Jordan, Kahtan Hasan ,   Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, Wales, Zaqaibeh Belal ,   Faculty of Science and Information Technology, Jadara University, Irbid, Jordan, Al-Khawaja Haneen A. ,   Department of Financial Technology and Banking, Faculty of Business, Ajloun National University, Ajloun, Jordan,   Applied Science Research Center, Applied Science Private University, Amman, Jordan,   Swiss FinTech Innovation Lab, University of Zurich, Zurich, Switzerland
Published: October 2024

This study examines web application performance testing by focusing on responsiveness, throughput, and scalability to evaluate the effectiveness of computer systems, networks, and software applications. It assesses a specific protocol's performance through four tests: performance load, process start-up time, web application infrastructure, and resource allocation. Using Apache JMeter, tests were conducted on the RSMD and E-government websites. The results revealed instability and performance degradation in the RSMD website over time, with server-to-client response time increasing as the test duration and load increased. The E-GOV website's performance initially appeared stable but also degraded over time. A test ramp time of 10 seconds and five looping iterations showed significant performance degradation. Future research should address these issues to improve web application performance under load conditions. The study also discusses testing tools, including JMeter, for evaluating website performance under various load conditions. Key findings include the instability of the RSMD website and the performance deterioration of the E-GOV website, especially in scenarios with a 10-second ramp time and five loop iterations. These insights provide valuable guidance for developing strategies to optimize website performance under high-traffic conditions.
DESIGN AND DEVELOPMENT OF VIBROARTHOGRAM SCREENING DEVICE AND ASSESSMENT OF JOINT MOTION IN THE PURSUIT OF SIGNAL PROCESSING
Authors:   Muthayammal Engineering College, India, R Praveena , D K Ravish ,   Dr. Ambedkar Institute of Technology, India, Babu T R Ganesh ,   Muthayammal Engineering College, India, J Preetha ,   Muthayammal Engineering College, India
Published: October 2024

Abnormal conditions in the knee joint are factors to lead changes in the vibroarthro graphic signal which represents the sound or vibration emitted from the joint during flexion or extension with suitable instrumentation these signals are to be acquired and also converted into digital signal. Signals are amplitude limited, distorted limited length and non-stationary in nature. The vibroarthro graphic system is unknown, modeling of vibroarthro graphic signal are essential to explore physiological behavior. Biosignal Processing and Pattern classification techniques have been applied to vibroarthro graphic signals to derive features that characterize the state of articular cartilage surface and assist in non-invasive detection of knee joint pathology. Screening of knee joint abnormal condition using vibroarthro graphic signals could reduce the need for diagnostic surgery. Diagnostic surgeries are invasive techniques and could deteriorate joints as well. In the first part of the work suitable instrumentation setup is designed and developed. Subsequent second part of work is extended to model vibroarthro graphic signal and algorithms are used to assess joint motion in the pursuit of signal processing.
AN IMPROVISED METHOD USING NEURO-FUZZY SYSTEM FOR FINANCIAL TIME SERIES FORECASTING
Authors:   Anjuman-I-Islam’s Kalsekar Technical Campus, India, Gandhi Mohd. Asif , Sri S.M. Lekshmi ,   Dr. J.J. Magdum College of Engineering, India, Singh Bhanu Pratap ,   Auro University, India, Aalam Zahir ,   Thakur College of Engineering and Technology, India, Pal Subharun ,   Indian Institute of Technology, Jammu, India
Published: October 2024

Financial time series forecasting is crucial for making informed investment decisions. This study proposes an improvised method utilizing a Neuro-Fuzzy System (NFS) for enhanced forecasting accuracy. Traditional forecasting methods often struggle with the nonlinear and dynamic nature of financial time series data. NFS integrates neural network and fuzzy logic techniques, offering a robust framework for modeling complex relationships within financial data. The proposed method employs NFS to adaptively learn and model the intricate patterns present in financial time series data. It combines the strengths of neural networks in learning complex patterns and fuzzy logic in handling uncertainty and imprecision. This study contributes by introducing an innovative approach to financial time series forecasting, leveraging the capabilities of NFS to improve forecasting accuracy and reliability. Experimental results demonstrate the effectiveness of the proposed method in accurately forecasting financial time series data. The method outperforms traditional forecasting techniques, showcasing its potential for practical applications in financial markets.
Cadence-Based Pedometer App With Financial Incentives to Enhance Moderate-to-Vigorous Physical Activity: Development and Single-Arm Feasibility Study (Preprint)
Authors: Hayashi Kosuke , Imai Hiromitsu , Oikawa Ichiro , Ishihara Yugo , Wakuda Hirokazu , Miura Iori , Uenohara Shingo , Kuwae Asuka , Kai Megumi , Furuya Ken'ichi , Uemura Naoto
Published: October 2024

BACKGROUND

High levels of physical activity are key to improving health outcomes, yet many people fail to take action. Using pedometers to target steps per day and providing financial incentives is a simple and scalable approach to promoting public health. However, conventional pedometers do not account for “intensity” and “duration,” making it challenging to efficiently increase people’s moderate-to-vigorous physical activity (MVPA), which is expected to improve health outcomes. Based on these rationales, we developed a smartphone app that sets step cadence as a goal (defined as a daily challenge of walking more than 1500 steps in 15 minutes twice a day, which is a heuristic threshold for moderate physical activity) and provides financial incentive when the challenge is met.

OBJECTIVE

This study aimed to evaluate the feasibility of our novel app and explore whether its use can increase users’ daily MVPA.

METHODS

A single-arm pre-post study evaluated the feasibility and efficacy of the app. A total of 15 participants used app 1 (an app without financial incentives) for the first period (4 weeks) and then switched to app 2 (an app with financial incentives) for the second period (4 weeks). The primary outcome was the difference between the first and second periods in the number of successful challenge attempts per week. Secondary outcomes were differences between the first and second periods in daily steps and distance walked. Exploratory outcomes included the difference between the first and second periods in daily “heart points” as measured by Google Fit, a publicly available app that measures users’ daily MVPA.

RESULTS

The number of successful challenge attempts per week increased significantly compared to the first period (5.6 times per week vs 0.7 times per week; P<.001). Although not statistically significant, there was a trend toward an increase in the mean steps per day and distance walked per day (6586 steps per day vs 5950 steps per day; P=.19; and 4.69 km per day vs 3.85 km per day; P=.09, respectively). An exploratory end point examining daily MVPA by “heart points” collected from Google Fit also showed a significant increase compared to the first period (22.7 points per day vs 12.8 points per day; P=.02).

CONCLUSIONS

Our app using step cadence as a goal and providing financial incentives seemed feasible and could be an effective app to increase users’ daily MVPA. Based on the results of this study, we are motivated to conduct a confirmatory study with a broader and larger number of participants.

CLINICALTRIAL

UMIN 000050518; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000057420
Mental Health Monitoring for Young People Through Mood Apps: Protocol for a Scoping Review and Systematic Search in App Stores (Preprint)
Authors: Boege Selina , Milne-Ives Madison , Ananthakrishnan Ananya , Cong Cen , Sharma Aditya , Anderson David , Meinert Edward
Published: October 2024

BACKGROUND

The researchers have used mobile phones to assist in monitoring, analyzing, and managing moods to acquire insight into mood patterns. There is a lack of evidence in their use as clinical tools and interventions, which necessitates a comprehensive review and quality assessment to understand barriers and facilitators for app implementation as an impactful clinical intervention.

OBJECTIVE

This review aims to (1) provide an overview of the recent evidence on mobile mood-monitoring apps that are intended for facilitating self-management and support of mental health in children, adolescents, and young people; and (2) investigate the quality of publicly available apps.

METHODS

The study will first involve a scoping review of the literature on mood-monitoring apps for children, adolescents, and young people followed by an evaluation of features of the apps available in the marketplace. The scoping review will follow the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines and search 6 databases— Embase, CINAHL, PubMed, ACM Digital Library, Scopus, and Springer LNCS—for relevant studies and reviews published in the last 3 years. The author will then screen the references, extract data from the included studies, and analyze them to synthesize the evidence on mood apps. Next, the Apple App Store and Google Play Store will be searched for mood apps. A total of 2 independent reviewers will screen the apps based on eligibility criteria, and disagreements will be resolved through consensus. The features of the selected apps will then be evaluated using the Mobile Health Index and Navigation framework, and descriptive analysis will be used to synthesize the findings.

RESULTS

Literature search and screening began soon after submission of the protocol and is expected to be completed by September 2024. The app evaluation will be completed by October 2024.

CONCLUSIONS

Combined, the scoping literature review and app evaluation will provide an in-depth overview of the most recent scientific evidence related to mood apps and the quality of apps actually available for use.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/56400
The Puzzle and Promise of Human Dignity: R v Bissonnette
Authors: Major Blair
Published: October 2024

For all its promise, human dignity is also a puzzle. This paper’s discussion of the use of human dignity in Bissonnette is approached from this perspective. The goal is not only to explore how human dignity is developed in the context of section 12 of the Charter but, in doing so, to also shine a light on some of the broader challenges and possibilities that courts will have to engage with when using human dignity in law. I will leave it to the reader to judge for themselves whether the use of human dignity in Bissonnette is more promise or more puzzle. I tend to see both present, and a glaring need to develop a more robust theorization of human dignity and its use in Canadian law.
Problems of Good Governance in Managing Indonesia’s Borderland: The Case of Entikong Subdistrict
Authors: Rusdiono Rusdiono , Darmawan Sudagung Adityo , Addin Linando Jaya , Ningtias Kartika
Published: October 2024

The present study explores the good governance processes of border management in Entikong Subdistrict. The Entikong Subdistrict in West Kalimantan is a priority district that receives special attention from Indonesian central and local governments. The Entikong border post started operating in 1989, making it the first land border in Indonesia. Nevertheless, despite its aged history and many development efforts within the area, the economic growth and welfare of the border community remained stagnant. The data for this article were collected through a field work in Entikong for four months in 2022 in which we conducted observation, interviews, and focus group discussion with local residents and government officers. This study reveals that good governance became the focal issue explaining Entikong’s lack of development by providing two problems in the border development at Entikong: 1) the government’s inconsistency on the road widening project and 2) the complexity of governance and bureaucracy. This paper further elaborates on the essence of locality in good governance practices while simultaneously addressing the authority division problems and communication towards the demands of the local community. This study argues that better public communication patterns should be implemented to avoid misunderstandings within the community and increase the participation of local citizens, government, and civil society in the development process of the border area.
Physicochemical Properties, Chemical Composition, Antioxidant Properties, and Antibacterial Effects of Four Palestinian Honey Varieties
Authors: Abu-Farich Basheer , Masalha Mahmud , Egbaria Eisaam , Kmail Abdalsalam , El Ghouizi Asmae , Ali Doha Weld , Lyoussi Badiaa , Saad Bashar
Published: October 2024

The present study evaluates the physicochemical attributes, antibacterial efficacy, and antioxidant capacities of four distinct varieties of honey from the West Bank region of Palestine: Assal Barsem (Medicago sativa) AB, Assal Morar (Centaurea dumulosa Boiss) AM, Assal Horfesh (Silybum) AH, and Assal Sader (Ziziphus spina-christi) AS. The analysis encompassed parameters such as pH, electrical conductivity, Total Flavonoid Content (TFC), and Total Phenolic Content (TPC). Furthermore, the antioxidant potential was gauged through Total Antioxidant Capacity (TAC) determination and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. In addition, the antibacterial effectiveness of the honeys was measured against a spectrum of bacterial strains including Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae, and Bacillus subtilis, utilizing minimum inhibitory concentration (MIC) and Minimum Bactericidal Concentrations (MBC). The outcomes of the physicochemical analysis adhered to the quality benchmarks outlined by the European Union Commission and the Codex Alimentarius Commission. The MIC and MBC values exhibited notable variance across the tested honey varieties, with MIC values ranging from 0.024% w/w to 1.56% w/w, and MBC values ranging from 0.048% w/w to 3.15% w/w. Particularly, AH demonstrated superior efficacy against all seven bacterial strains, with MIC values spanning from 0.1 to 0.6% w/w, and MBC values ranging from 0.3% w/w to 0.8% w/w. Staphylococcus aureus and Escherichia coli were notably susceptible to all honey samples. Collectively, our findings underscore the therapeutic potential of Palestinian honey varieties, highlighting their multifaceted health-promoting attributes. Further exploration is warranted to elucidate the mechanistic underpinnings of bioactive constituents and explore their potential applications in healthcare.
A Review of Clinical Research on Gamchosasim-tang for Helicobacter Pylori Associated Gastric Ulcer
Authors: Kim Minjeong , Park Chaehyun , Park Jae-woo , Ko Seok-jae
Published: October 2024

Objectives: The purpose of this study was to investigate clinical research trends regarding the efficacy of Gamchosasim-tang on Helicobacter pylori-associated gastric ulcer.Methods: Studies were searched on Pubmed, CNKI, and domestic databases (OASIS, ScienceON, RISS, KISS, and Kmbase) using keywords such as “helicobacter”, “h. pylori”, “ulcer”, and “Gancao Xiexin.” Data on the publication year, characteristics of patients, diagnosis methods, interventions, outcome measures, and results were extracted. The quality of each study was assessed using a risk-of-bias tool.Results: In total, eight studies were selected. All were randomized-controlled trials. Gamchosasim-tang and quadruple therapy were co-administered for the treatment group in most of the studies. A combination of Gamchosasim-tang and eradication therapy was effective in improving disease-associated symptoms and lowering recurrence rate. No obvious side effects were observed in any of the studies.Conclusion: Gamchosasim-tang can be a safe and effective treatment method for helicobacter pylori-associated gastric ulcer, so it can be used in clinical practice.
A Study on the Correlation between Xerostomia, Yin Deficiency, and Heart Rate Variability in Halitosis Patients
Authors: Choi Song , Kim Hyun-ji , Im Seung-kyu , Moon Young-ho
Published: October 2024

Objectives: The purpose of this study was to analyze the correlation between the level of xerostomia and Yin deficiency as well as heart rate variability in patients with halitosis.Methods: A survey was conducted on 30 patients who visited the Department of Internal Medicine at Dongsin University Oriental Hospital from March 2021 to February 2022. A questionnaire regarding halitosis and xerostomia was administered using the Visual Analogue Scale (VAS) scores, and Yin deficiency was assessed using 10 specific items. Oral moisture was measured using the Oral Moisture Checking Device (Mucus) under unstimulated conditions, while heart rate variability was measured with the SA-6000 equipment.Results: A significant positive correlation was found between VAS scores for halitosis and xerostomia and Yin deficiency. However, there was no correlation between xerostomia and the Mucus scores. The low Mucus score group showed a significant negative correlation with LF values compared to the normal Mucus score group.Conclusion: Patients with halitosis who experience xerostomia are likely to be in a state of Yin deficiency.