bluuebunny/crossref_metadata_2025 huggingface dataset:
A 2.53 NEF 8-bit 10 kS/s 0.5 μm CMOS Neural Recording Read-Out Circuit with High Linearity for Neuromodulation Implants
Authors: Tasneem Nishat Tarannum , Mahbub Ifana
Published: March 2021

This paper presents a power-efficient complementary metal-oxide-semiconductor (CMOS) neural signal-recording read-out circuit for multichannel neuromodulation implants. The system includes a neural amplifier and a successive approximation register analog-to-digital converter (SAR-ADC) for recording and digitizing neural signal data to transmit to a remote receiver. The synthetic neural signal is generated using a LabVIEW myDAQ device and processed through a LabVIEW GUI. The read-out circuit is designed and fabricated in the standard 0.5 μμm CMOS process. The proposed amplifier uses a fully differential two-stage topology with a reconfigurable capacitive-resistive feedback network. The amplifier achieves 49.26 dB and 60.53 dB gain within the frequency bandwidth of 0.57–301 Hz and 0.27–12.9 kHz to record the local field potentials (LFPs) and the action potentials (APs), respectively. The amplifier maintains a noise–power tradeoff by reducing the noise efficiency factor (NEF) to 2.53. The capacitors are manually laid out using the common-centroid placement technique, which increases the linearity of the ADC. The SAR-ADC achieves a signal-to-noise ratio (SNR) of 45.8 dB, with a resolution of 8 bits. The ADC exhibits an effective number of bits of 7.32 at a low sampling rate of 10 ksamples/s. The total power consumption of the chip is 26.02 μμW, which makes it highly suitable for a multi-channel neural signal recording system.
Two-Stage Evaporative Inlet Air Gas Turbine Cooling
Authors: Zeitoun Obida
Published: March 2021

Gas turbine inlet air-cooling (TIAC) is an established technology for augmenting gas turbine output and efficiency, especially in hot regions. TIAC using evaporative cooling is suitable for hot, dry regions; however, the cooling is limited by the ambient wet-bulb temperature. This study investigates two-stage evaporative TIAC under the harsh weather of Riyadh city. The two-stage evaporative TIAC system consists of indirect and direct evaporative stages. In the indirect stage, air is precooled using water cooled in a cooling tower. In the direct stage, adiabatic saturation cools the air. This investigation was conducted for the GE 7001EA gas turbine model. Thermoflex software was used to simulate the GE 7001EA gas turbine using different TIAC systems including evaporative, two-stage evaporative, hybrid absorption refrigeration evaporative and hybrid vapor-compression refrigeration evaporative cooling systems. Comparisons of different performance parameters of gas turbines were conducted. The added annual profit and payback period were estimated for different TIAC systems.
Challenges and Opportunities for End-of-Life Coal Mine Sites: Black-to-Green Energy Approach
Authors: Frejowski Aleksander , Bondaruk Jan , Duda Adam
Published: March 2021

This paper presents the possibilities of adapting active mines to generate green energy after their closure using their resources and/or infrastructure. For this purpose, firstly, the temporal horizon of selected mines in Poland was determined, its basic assumption being the analysis of the current state. In the research, 18 mining plants operating within 12 mines in the Upper Silesian Coal Basin (USCB) were analyzed. The analyzed mines belong to three of the five largest hard coal producers in Poland, and the main object of exploitation is hard coal of energy types. Severe restrictions or even abandonment of further investments in the development of the coal mining industry were taken into consideration (regarding the construction of new shafts or the development of new exploitation levels). When determining the temporal horizon, the challenges that hamper the exploitation based at the levels of natural hazards and depth of exploitation in each mine were considered. Secondly, the criteria for the adaptation of active mines to generate energy are presented. The possibility of using the resources and infrastructural potential of active mines to produce geothermal energy from water, extracting coalbed methane (CBM), and processes of underground coal gasification (UCG) are analyzed. Finally, for a selected example—generating energy from underground coal gasification in Polish mine conditions—a structural analysis of the criteria was performed using the MICMAC method, as the Central Mining Institute has an extensive experience in the development of underground coal gasification trials in coal mines. Based on expert analysis and using structural analysis, the criteria important for UCG were selected. As demonstrated in the article, the MICMAC method can be applied in other scenarios with different criteria to implement new technologies in coal mines.
Influence of the Reshaped Elbow on the Unsteady Pressure Field in a Simplified Geometry of the Draft Tube
Authors: Szakal Raul-Alexandru , Doman Alexandru , Muntean Sebastian
Published: March 2021

The paper focuses on the influence of the reshaped elbow geometry of the draft tube on the unsteady pressure field under different operating conditions. The experimental investigations are conducted considering two simplified geometrical configurations of the draft tubes with sharp heel elbow and modified/reshaped elbow, respectively. The discriminated power spectra (rotating and plunging components) of the acquired pressure signals on the wall are determined on five levels for seven operating conditions to quantify the influence of the reshaped elbow. The influence of the reshaped elbow on the fundamental frequencies of both rotating and plunging components and on the amplitude of the rotating component is negligible. In contrast, the equivalent amplitude associated with the root mean square of the plunging power spectrum that propagates along the hydraulic passage is mitigated up to 25% by the reshaped geometry of the elbow. The equivalent amplitude on the narrow band around the fundamental frequency of the plunging component is diminished with 40–50% by reshaping the elbow geometry of the simplified draft tube.
Motivation and Preferences of Visitors in the Bohemian Paradise UNESCO Global Geopark
Authors: Drápela Emil , Boháč Artur , Böhm Hynek , Zágoršek Kamil
Published: March 2021

There are some localities in the Bohemian Paradise Geopark that suffer from temporal overtourism in the high season. On the other hand, more than half of the geopark is not so often visited by tourists, although very attractive geosites can be found there too. In the most visited localities, nature is damaged due to overloading of the tourist infrastructure, while elsewhere there is pressure driven by municipalities to increase the number of tourists. For this reason, we organized a large questionnaire survey in summer 2020, which aimed to reveal the motivation of visitors of the geopark and their preferences regarding the places visited. The questionnaire combined several research methods: graphic scales, qualitative open questions, mental map, etc. The analysis of visitors’ answers shows that most of them cannot be described as geotourists, i.e., tourists who are primarily interested in geology and conceive their holiday as a sightseeing stay. Many tourists like to stay in nature without an educational element. We also found that there is a higher proportion of ecotourists and geotourists in less-visited geosites because they appreciate even lesser-known localities and crowds of tourists rather than repel them. The question for the future is, therefore, whether the geopark should strive for greater promotion of lesser-known localities, which would attract even mainstream tourists, or, conversely, to protect these geosites, it should promote only the most visited localities (which are already damaged).
Short-Term Effect of Kinesio Taping of Lower-Leg Proprioceptive Neuromuscular Facilitation Pattern on Gait Parameter and Dynamic Balance in Chronic Stroke with Foot Drop
Authors: Lee Dongyun , Bae Youngsook
Published: March 2021

The aim of this study is to identify the effectiveness of proprioceptive neuromuscular facilitation (PNF) leg Kinesio taping on gait parameters and dynamic balance in chronic stroke patients with foot drop. A total 22 chronic stroke patients were randomly assigned to experimental (n = 11) and control groups (n = 11). All subjects underwent conventional therapy and gait training for 50 min. The experimental group additionally received KT of tibialis anterior muscle (TA) and hamstring muscles according to the PNF pattern. The control group received KT of only TA. The primary outcome measures that the gait parameter are gait velocity, cadence, step length, and stride length. Dynamic balance was measured by the timed up-and-go test (TUG) time and activity-specific balance confidence scale (ABC) as the secondary outcomes. All of the measurements were performed baseline and 24 h after intervention. Our results showed that the experimental group showed significant improvements in gait velocity, cadence, step length, stride length and TUG, and ABC score compared with the control group. We conclude that the short term effect of application of lower-leg KT according to the PNF pattern increased the gait ability and dynamic balance of chronic stroke patients with foot drop.
Estimates of the Ambient Population: Assessing the Utility of Conventional and Novel Data Sources
Authors: Whipp Annabel , Malleson Nicolas , Ward Jonathan , Heppenstall Alison
Published: March 2021

This paper will critically assess the utility of conventional and novel data sources for building fine-scale spatio-temporal estimates of the ambient population. It begins with a review of data sources employed in existing studies of the ambient population, followed by preliminary analysis to further explore the utility of each dataset. The identification and critiquing of data sources which may be useful for building estimates of the ambient population are novel contributions to the literature. This paper will provide a framework of reference for researchers within urban analytics and other areas where an accurate measurement of the ambient population is required. This work has implications for national and international applications where accurate small area estimates of the ambient population are crucial in the planning and management of urban areas, the development of realistic models and informing policy. This research highlights workday population estimates, in conjunction with footfall camera and Wi-Fi sensors data as potentially valuable for building estimates of the ambient population.
Cyclists at Roundabouts: Risk Analysis and Rational Criteria for Choosing Safer Layouts
Authors: Cantisani Giuseppe , Durastanti Claudio , Moretti Laura
Published: March 2021

Cycling for transportation is an important resource to reduce urban traffic congestion, enhance personal health, reduce energy consumption, and improve air quality, and the safety of cyclists in the cities is becoming a topic of growing interest. As shown in the literature, an important number of cyclist fatalities is due to road crashes occurring at urban intersections. This study combines a probabilistic and a damage model to perform a risk analysis for the collisions between motor vehicles and bicycles in the merging and diverging conflict points of a single-lane conventional roundabout with four arms, characterized by a permanent traffic flow. The probabilistic model is based on Poisson’s law and is aimed to measure the probability of a collision between bikes and motor vehicles within the elementary unit of exposure in each conflict point of the roundabout. The damage model exploits the reaction time of a road user to avoid a collision and has been built to develop a danger classification for the conflict points. The goal of this study is then to estimate the so-called risk of collision at the roundabout, to compare different possible layouts for various traffic volumes with increasing bike flows and geometric configurations, and to identify the most effective solutions to improve safety for cyclists. The results demonstrate the risk reduction given by a roundabike compared to a standard layout where cyclists and motor vehicles share the circulatory roadway. Therefore, the study here presented could help road managers to implement mitigation strategies taking into consideration both geometric and functional constraints.
Interstitial Lung Disease Worsens Short- and Long-Term Outcomes of Systemic Rheumatic Disease Patients Admitted to the ICU: A Multicenter Study
Authors: Banuls Lorrain , Vanoverschelde Juliette , Garnier Fanny , Amalric Matthieu , Jaber Samir , Charbit Jonathan , Chalard Kevin , Mourad Marc , Benchabane Nacim , Benomar Racim , Besnard Noemie , Daubin Delphine , Brunot Vincent , Klouche Kada , Larcher Romaric
Published: March 2021

Critically ill patients with systemic rheumatic diseases (SRDs) have a fair prognosis, while those with interstitial lung disease (ILD) have a poorer outcome. However, the prognosis of SRD patients with ILD admitted to the intensive care unit (ICU) remains unclear. We conducted a case–control study to investigate the outcomes of critically ill SRD-ILD patients. Consecutive SRD-ILD patients admitted to five ICUs from January 2007 to December 2017 were compared to SRD patients without ILD. Mortality rates were compared between groups, and prognostic factors were then identified. One hundred and forty critically ill SRD patients were included in the study. Among the 70 patients with SRD–ILD, the SRDs were connective tissue diseases (56%), vasculitis (29%), sarcoidosis (13%), and spondylarthritis (3%). Patients were mainly admitted for acute exacerbation of SRD-ILD (36%) or infection (34%). ICU, in-hospital, and one-year mortality rates in SRD-ILD patients were higher than in SRD patients without ILD (n = 70): 40% vs. 16% (p < 0.01), 49% vs. 19% (p < 0.01), and 66% vs. 40% (p < 0.01), respectively. Hypoxemia, high sequential organ failure assessment (SOFA) score, and admission for ILD acute exacerbation were associated with ICU mortality. In conclusion, ILD worsened the outcomes of SRD patients admitted to the ICU. Admissions related to SRD-ILD acute exacerbation and the severity of the acute respiratory failure were associated with ICU mortality.
RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates
Authors: Huber Bettina , Wang Joshua Weiyuan , Roden Richard B. S. , Kirnbauer Reinhard
Published: March 2021

Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-assembled from L1 major-capsid proteins that are remarkably effective prophylactic immunogens. However, the induced type-restricted immune response limits coverage to the included vaccine types, and costly multiplex formulations, restrictive storage and distribution conditions drive the need for next generation HPV vaccines. Vaccine candidates based upon the minor structural protein L2 are particularly promising because conserved N-terminal epitopes induce broadly cross-type neutralizing and protective antibodies. Several strategies to increase the immunological potency of such epitopes are being investigated, including concatemeric multimers, fusion to toll-like receptors ligands or T cell epitopes, as well as immunodominant presentation by different nanoparticle or VLP structures. Several promising L2-based vaccine candidates have reached or will soon enter first-in-man clinical studies. RG1-VLP present the HPV16L2 amino-acid 17–36 conserved neutralization epitope “RG1” repetitively and closely spaced on an immunodominant surface loop of HPV16 L1-VLP and small animal immunizations provide cross-protection against challenge with all medically-significant high-risk and several low-risk HPV types. With a successful current good manufacturing practice (cGMP) campaign and this promising breadth of activity, even encompassing cross-neutralization of several cutaneous HPV types, RG1-VLP are ready for a first-in-human clinical study. This review aims to provide a general overview of these candidates with a special focus on the RG1-VLP vaccine and its road to the clinic.
Short-Periods of Pre-Warming in Laparoscopic Surgery. A Non-Randomized Clinical Trial Evaluating Current Clinical Practice
Authors: Becerra Ángel , Valencia Lucía , Villar Jesús , Rodríguez-Pérez Aurelio
Published: March 2021

Background: Pre-warming prevents perioperative hypothermia. We evaluated the current clinical practice of pre-warming and its effects on temperature drop and postoperative complications; Methods: This prospective, observational pilot study examines clinical practice in a tertiary hospital on 99 patients undergoing laparoscopic urological surgery. Pre-warming was performed in the pre-anesthesia room. Patients were classified into three groups: P 0 (non-prewarmed), P 5–15 (pre-warming 5–15 min) and P > 15 (pre-warming 15–30 min). Tympanic temperature was recorded in the pre-anesthesia room, prior to anesthesia induction, and in the PACU. Esophageal temperature was recorded intraoperatively. The occurrence of shivering, pain intensity, length of stay in PACU, and postoperative complications during hospital stay were also recorded; Results: After pre-warming, between-group difference in body temperature was higher in P > 15 than in P 0 (0.4 °C, 95% CI 0.14–0.69, p = 0.004). Between P 5–15 and P 0 difference was 0.2 °C (95% CI 0.04–0.55, p = 0.093). Temperature at the end of surgery was higher in pre-warmed groups [mean between-group difference 0.5 °C (95% CI 0.13–0.81, p = 0.007) for P 5–15; 0.9 °C (95% CI 0.55–1.19, p < 0.001) for P > 15]. Pain and shivering was less common in pre-warmed groups. Postoperative transfusions and surgical site infections were lower in P > 15; Conclusion: Short-term pre-warming prior to laparoscopic urological surgery decreased temperature perioperative drop and postoperative complications.
Diagnostic Process Using Endoscopy for Biliary Strictures: A Narrative Review
Authors: Tanisaka Yuki , Mizuide Masafumi , Fujita Akashi , Ogawa Tomoya , Suzuki Masahiro , Katsuda Hiromune , Saito Youichi , Miyaguchi Kazuya , Tashima Tomoaki , Mashimo Yumi , Ryozawa Shomei
Published: March 2021

The diagnostic process for biliary strictures remains challenging in some cases. A broad differential diagnosis exists for indeterminate biliary strictures, including benign or malignant lesions. The diagnosis of indeterminate biliary strictures requires a combination of physical examination, laboratory testing, imaging modalities, and endoscopic procedures. Despite the progress of less invasive imaging modalities such as transabdominal ultrasonography, computed tomography, and magnetic resonance imaging, endoscopy plays an essential role in the accurate diagnosis, including the histological diagnosis. Imaging findings and brush cytology and/or forceps biopsy under fluoroscopic guidance with endoscopic retrograde cholangiopancreatography (ERCP) are widely used as the gold standard for the diagnosis of biliary strictures. However, ERCP cannot provide an intraluminal view of the biliary lesion, and its outcomes are not satisfactory. Recently, peroral cholangioscopy, confocal laser endomicroscopy, endoscopic ultrasound (EUS), and EUS-guided fine-needle aspiration have been reported as useful for indeterminate biliary strictures. Appropriate endoscopic modalities need to be selected according to the patient’s condition, the lesion, and the expertise of the endoscopist. The aim of this review article is to discuss the diagnostic process for indeterminate biliary strictures using endoscopy.
Diet, Obesity, and Depression: A Systematic Review
Authors: Patsalos Olivia , Keeler Johanna , Schmidt Ulrike , Penninx Brenda W. J. H. , Young Allan H. , Himmerich Hubertus
Published: March 2021

Background: Obesity and depression co-occur in a significant proportion of the population. Mechanisms linking the two disorders include the immune and the endocrine system, psychological and social mechanisms. The aim of this systematic review was to ascertain whether weight loss through dietary interventions has the additional effect of ameliorating depressive symptoms in obese patients. Methods: We systematically searched three databases (Pubmed, Medline, Embase) for longitudinal clinical trials testing a dietary intervention in people with obesity and depression or symptoms of depression. Results: Twenty-four longitudinal clinical studies met the eligibility criteria with a total of 3244 included patients. Seventeen studies examined the effects of calorie-restricted diets and eight studies examined dietary supplements (two studies examined both). Only three studies examined people with a diagnosis of both obesity and depression. The majority of studies showed that interventions using a calorie-restricted diet resulted in decreases in depression scores, with effect sizes between ≈0.2 and ≈0.6. The results were less clear for dietary supplements. Conclusions: People with obesity and depression appear to be a specific subgroup of depressed patients in which calorie-restricted diets might constitute a promising personalized treatment approach. The reduction of depressive symptoms may be related to immunoendocrine and psychosocial mechanisms.
Population Trends and Urbanisation in Mountain Ranges of the World
Authors: Ehrlich Daniele , Melchiorri Michele , Capitani Claudia
Published: March 2021

This study assesses the global mountain population, population change over the 1975–2015 time-range, and urbanisation for 2015. The work uses the World Conservation Monitoring Centre (WCMC) definition of mountain areas combined with that of mountain range outlines generated by the Global Mountain Biodiversity Assessment (GMBA). We estimated population change from the Global Human Settlement Layer Population spatial grids, a set of population density layers used to measure human presence and urbanisation on planet Earth. We show that the global mountain population has increased from over 550 million in 1975 to over 1050 million in 2015. The population is concentrated in mountain ranges at low latitudes. The most populated mountain ranges are also the most urbanised and those that grow most. Urbanisation in mountains (66%) is lower than that of lowlands (78%). However, 34% of the population in mountains live in cities, 31% in towns and semi-dense areas, and 35% in rural areas. The urbanisation rate varies considerably across ranges. The assessments of population total, population trends, and urbanisation may be used to address the issue “not to leave mountain people behind” in the sustainable development process and to understand trajectories of change.
Correlation of Global Quantities at Material Characterization of Pressure-Sensitive Materials Using Sharp Indentation Testing
Authors: Dahlberg Carl F. O. , Faleskog Jonas , Larsson Per-Lennart
Published: March 2021

Correlation of sharp indentation problems is examined theoretically and numerically. The analysis focuses on elastic-plastic pressure-sensitive materials and especially the case when the local plastic zone is so large that elastic effects on the mean contact pressure will be small or negligible as is the case for engineering metals and alloys. The results from the theoretical analysis indicate that the effect from pressure-sensitivity and plastic strain-hardening are separable at correlation of hardness values. This is confirmed using finite element methods and closed-form formulas are presented representing a pressure-sensitive counterpart to the Tabor formula at von Mises plasticity. The situation for the relative contact area is more complicated as also discussed.
Improved Breakdown Strength of Polypropylene Film by Polycyclic Compounds Addition for Power Capacitors
Authors: Xu Ranran , Xing Jiwen , Du Boxue , Xiao Meng , Li Jin
Published: March 2021

In this paper, an improved method for the electric performance of polypropylene (PP) film was proposed to promote the safety and stability of power capacitors. Modified PP films containing three different polycyclic compounds were prepared, which showed good thermal properties and decreased DC conductivity. The DC breakdown strength of the modified PP films under both positive and negative voltage is increased compared with that of the original film. The deep traps introduced by polycyclic compounds and the decreased carrier mobility give an explanation of the decreased DC conductivity. A quantum chemistry calculation was further performed to clarify the mechanism for improving electrical performance, presenting that polycyclic compounds with a high electron affinity and low ionization energy can capture high-energy electrons, protecting the PP molecular chain from attack, and then increase the breakdown strength. It is concluded that the modified PP films by polycyclic compounds have great potential in improving the insulating properties of power capacitors.
Hot-Probe Characterization of Transparent Conductive Thin Films
Authors: Axelevitch Alexander
Published: March 2021

Transparent conductive oxide (TCO) thin films represent a large class of wide-bandgap semiconductors applied in all fields of micro- and optoelectronics. The most widespread material applied for the creation of TCO coatings is indium-tin oxide (ITO). At the same time, there are plurality trends to change the high-cost ITO on other materials, for example, on the ZnO doped by different elements such as Al, Mn, and Sb. These films require mobile and low-cost evaluation methods. The dynamic hot-probe measurement system is one of such techniques that can supplement and sometimes replace existing heavy systems such as the Hall effect measurements or the Haynes–Shockley experiments. The theoretical basis and the method of analysis of the recorded dynamic hot-probe characteristics measured at different temperatures were presented in this work. This method makes it possible to extract the main parameters of thin films. Commercial thin ITO films and new transparent conducting ZnO:Al layers prepared by magnetron co-sputtering were studied by the proposed method. The measured parameters of commercial ITO films are in agreement with the presented and reference data. In addition, the parameters of ZnO:Al thin films such as the majority charge carriers type, concentration, and mobility were extracted from dynamic hot-probe characteristics. This method may be applied also to other wide-bandgap semiconductors.
Improvement of Corrosion Resistance of TiO2 Layers in Strong Acidic Solutions by Anodizing and Thermal Oxidation Treatment
Authors: Minhas Badar , Dino Sahib , Zuo Yu , Qian Hongchang , Zhao Xuhui
Published: March 2021

By anodization and thermal oxidation at 600 °C, an oxide layer on Ti with excellent corrosion resistance in strong acid solutions was prepared. The structural properties of TiO2 films before and after thermal oxidation were investigated with methods of Scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The electrochemical characterization was recorded via electrochemical impedance spectroscopy, potentiodynamic polarization and Mott–Schottky methods. XRD results show that a duplex rutile/anatase structure formed after oxidation, and the amount of anatase phase increased as the treatment time was prolonged from 3 to 9 h. XPS analysis indicates that as the thermal oxidation time increased, more Ti vacancies were present in the titanium oxide films, with decreased donor concentration. Longer thermal oxidation promoted the formation of hydroxides of titanium on the surface, which is helpful to improve the passive ability of the film. The anodized and thermally oxidized Ti samples showed relatively high corrosion resistance in 4 M HCl and 4 M H2SO4 solutions at 100 ± 5 °C. The passive current density values of the thermally oxidized samples were five orders of magnitude under the testing condition compared with that of the anodized sample. With the oxidation time prolonged, the passive current density decreased further to some extent.
Erratum: Ossig, C., et al. Four-Fold Multi-Modal X-ray Microscopy Measurements of a Cu(In, Ga)Se2 Solar Cell. Materials 2021, 14, 228
Authors: Ossig Christina , Strelow Christian , Flügge Jan , Kolditz Andreas , Siebels Jan , Garrevoet Jan , Spiers Kathryn , Seyrich Martin , Brückner Dennis , Pyrlik Niklas , Hagemann Johannes , Seiboth Frank , Schropp Andreas , Carron Romain , Falkenberg Gerald , Mews Alf , Schroer Christian G. , Kipp Tobias , Stuckelberger Michael E.
Published: March 2021

In the original version of our article [...]
Can the Treatment of Normal-Pressure Hydrocephalus Induce Normal-Tension Glaucoma? A Narrative Review of a Current Knowledge
Authors: Hamarat Yasin , Bartusis Laimonas , Deimantavicius Mantas , Lucinskas Paulius , Siaudvytyte Lina , Zakelis Rolandas , Harris Alon , Mathew Sunu , Siesky Brent , Janulevicienė Ingrida , Ragauskas Arminas
Published: March 2021

Ventriculoperitoneal shunt placement is the most commonly used treatment of normal-pressure hydrocephalus (NPH). It has been hypothesized that normal-tension glaucoma (NTG) is caused by the treatment of NPH by using the shunt to reduce intracranial pressure (ICP). The aim of this study is to review the literature published regarding this hypothesis and to emphasize the need for neuro-ophthalmic follow-up for the concerned patients. The source literature was selected from the results of an online PubMed search, using the keywords “hydrocephalus glaucoma” and “normal-tension glaucoma shunt”. One prospective study on adults, one prospective study on children, two retrospective studies on adults and children, two case reports, three review papers including medical hypotheses, and one prospective study on monkeys were identified. Hypothesis about the association between the treatment of NPH using the shunt to reduce ICP and the development of NTG were supported in all reviewed papers. This suggests that a safe lower limit of ICP for neurological patients, especially shunt-treated NPH patients, should be kept. Thus, we proposed to modify the paradigm of safe upper ICP threshold recommended in neurosurgery and neurology into the paradigm of safe ICP corridor applicable in neurology and ophthalmology, especially for shunt-treated hydrocephalic and glaucoma patients.
Direct Purification of Digestate Using Ultrafiltration Membranes: Influence of Pore Size on Filtration Behavior and Fouling Characteristics
Authors: Yue Caide , Dong Hongmin , Chen Yongxing , Shang Bin , Wang Yi , Wang Shunli , Zhu Zhiping
Published: March 2021

Ultrafiltration (UF) can effectively remove large particles, suspended solids, and colloidal substances from anaerobic digestate. However, membrane fouling is a technical challenge in the purification of the digestate by UF. In this study, polyethersulfone (PES) membranes with four pore sizes (50.0, 20.0, 10.0 and 5.0 kDa) were employed to filter anaerobic digestate from swine manure. The effects of temperature, transmembrane pressure (TMP), and cross-flow velocity (CFV) on flux were investigated. The purification effects and fouling characteristics of the four membranes were analyzed. The results revealed that the increase of temperature and CFV can effectively promote UF separation efficiency, but as the TMP exceeded 3.0 bar, the flux increase rates of the four membranes were almost zero. The larger membrane pore size caused the faster flux increase with the increase in pressure. During the batch experiment, the 20.0 kDa membrane showed the lowest flux maintenance ability, while the 5.0 kDa showed the highest ability due to the smaller pore size. All four membranes can effectively remove tetracyclines residues. Elements C, O, and S were the major membrane foulant elements. The dominant bacteria orders of membrane fouling were Pseudomonadales, Xanthomonadales and Burkholderiales. Compared with tap water and citric acid, the membrane cleaning by NaOH and NaClO showed higher flux recovery rates. The 50.0 kDa membrane achieved the best cleaning effects under all cleaning methods.
A Study on the Reduction Behavior of FeO by Analyzing Pore Characteristics Using the Labyrinth Coefficient at High Temperature
Authors: Shin Sang Gyun , Min Dong Joon
Published: March 2021

The effect of extrinsic porosity on the reduction behavior of FeO was evaluated by thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and the Brunauer–Emmett–Teller (BET) technique and analyzed using the labyrinth coefficient of FeO. The extrinsic pore exhibited an abnormal effect on reduction behavior in the range of less than 50% reduction degree, despite the increase in apparent porosity. SEM and BET analysis indicated that the abnormal reduction behavior by extrinsic pores at the initial reduction stage was speculated to be due to the characteristic of extrinsic pore that is open only at one end. However, the overall porosity and reduction rate after a 40% reduction revert to the normal relationship. In addition, the experimental results indicated that the abnormal effect of the extrinsic pores in the initial stage was mitigated by an increase in the temperature. The abnormal effect of extrinsic porosity on FeO reduction was mathematically analyzed using the labyrinth coefficient. It can be summarized that not only the number of pores, but also their quality and distribution are important in determining the reduction rate.
A Learning Analytics Conceptual Framework for Augmented Reality-Supported Educational Case Studies
Authors: Kazanidis Ioannis , Pellas Nikolaos , Christopoulos Athanasios
Published: March 2021

The deployment of augmented reality (AR) has attracted educators’ interest and introduced new opportunities in education. Additionally, the advancement of artificial intelligence has enabled educational researchers to apply innovative methods and techniques for the monitoring and evaluation of the teaching and learning process. The so-called learning analytics (LA) discipline emerged with the promise to revolutionize traditional instructional practices by introducing systematic and multidimensional ways to improve the effectiveness of the instructional process. However, the implementation of LA methods is usually associated with web-based platforms, which offer direct access to learners’ data with minimal effort or adjustments. On the other hand, the complex nature of immersive technologies and the diverse instructional approaches which are utilized in different scientific domains have limited the opportunities for research and development in this direction. Within these research contexts, we present a conceptual framework that describes the elements of an LA process tailored to the information that can be gathered from the use of educational applications, and further provide an indicative case study for AR-supported educational interventions. The current work contributes by elucidating and concretizing the design elements of AR-supported applications and provides researchers and designers with guidelines on how to apply instructional strategies in (augmented) real-world projects.
Perspectives on Atomic-Scale Switches for High-Frequency Applications Based on Nanomaterials
Authors: Dragoman Mircea , Aldrigo Martino , Dragoman Daniela
Published: March 2021

Nanomaterials science is becoming the foundation stone of high-frequency applications. The downscaling of electronic devices and components allows shrinking chip’s dimensions at a more-than-Moore rate. Many theoretical limits and manufacturing constraints are yet to be taken into account. A promising path towards nanoelectronics is represented by atomic-scale materials. In this manuscript, we offer a perspective on a specific class of devices, namely switches designed and fabricated using two-dimensional or nanoscale materials, like graphene, molybdenum disulphide, hexagonal boron nitride and ultra-thin oxides for high-frequency applications. An overview is provided about three main types of microwave and millimeter-wave switch: filament memristors, nano-ionic memristors and ferroelectric junctions. The physical principles that govern each switch are presented, together with advantages and disadvantages. In the last part we focus on zirconium-doped hafnium oxide ferroelectrics (HfZrO) tunneling junctions (FTJ), which are likely to boost the research in the domain of atomic-scale materials applied in engineering sciences. Thanks to their Complementary Metal-Oxide Semiconductor (CMOS) compatibility and low-voltage tunability (among other unique physical properties), HfZrO compounds have the potential for large-scale applicability. As a practical case of study, we present a 10 GHz transceiver in which the switches are FTJs, which guarantee excellent isolation and ultra-fast switching time.
Environmental Photocatalytic Degradation of Antidepressants with Solar Radiation: Kinetics, Mineralization, and Toxicity
Authors: Finčur Nina , Šojić Merkulov Daniela , Putnik Predrag , Despotović Vesna , Banić Nemanja , Lazarević Marina , Četojević-Simin Dragana , Agbaba Jasmina , Abramović Biljana
Published: March 2021

This work is focused on the kinetics, mineralization, and toxicological assessments of the antidepressant drug amitriptyline hydrochloride (AMI) in UV or solar illuminated aqueous suspensions of ZnO, TiO2 Degussa P25, and TiO2 Hombikat. ZnO was proven to be the most effective photocatalyst, and it was used for all further experiments under solar irradiation. The highest reaction rate was observed at 1.0 mg/mL of catalyst loading. In the investigated initial concentration range (0.0075–0.3000 mmol/L), the degradation rate of AMI increased with the increase of initial concentration in the investigated range. The effects of H2O2, (NH4)2S2O8, and KBrO3, acting as electron acceptors, along with molecular oxygen were also studied. By studying the effects of ethanol and NaI as a hydroxyl radical and hole scavenger, respectively, it was shown that the heterogeneous catalysis takes place mainly via free hydroxyl radicals. In the mineralization study, AMI photocatalytic degradation resulted in ~30% of total organic carbon (TOC) decrease after 240 min of irradiation; acetate and formate were produced as the organic intermediates; NH4+, NO3−, NO2− ions were detected as nitrogen byproducts. Toxicity assessment using different mammalian cell lines, showed that H-4-II-E was the most sensitive one.
Artificial Neural Network-Based Prediction of the Optical Properties of Spherical Core–Shell Plasmonic Metastructures
Authors: Vahidzadeh Ehsan , Shankar Karthik
Published: March 2021

The substitution of time- and labor-intensive empirical research as well as slow finite difference time domain (FDTD) simulations with revolutionary techniques such as artificial neural network (ANN)-based predictive modeling is the next trend in the field of nanophotonics. In this work, we demonstrated that neural networks with proper architectures can rapidly predict the far-field optical response of core–shell plasmonic metastructures. The results obtained with artificial neural networks are comparable with FDTD simulations in accuracy but the speed of obtaining them is between 100–1000 times faster than FDTD simulations. Further, we have proven that ANNs does not have problems associated with FDTD simulations such as dependency of the speed of convergence on the size of the structure. The other trend in photonics is the inverse design problem, where the far-field optical response of a spherical core–shell metastructure can be linked to the design parameters such as type of the material(s), core radius, and shell thickness using a neural network. The findings of this paper provide evidence that machine learning (ML) techniques such as artificial neural networks can potentially replace time-consuming finite domain methods in the future.
Persistence of Leptospira borgpetersenii Serovar Hardjo in Refrigerated Raw Milk: A Transmission Risk of Leptospirosis to Humans
Authors: Mazzotta Elisa , Ceglie Letizia , Giurisato Isabella , Bellinati Laura , Lucchese Laura , Marchione Silvia , Natale Alda
Published: March 2021

Leptospira borgpetersenii serovar Hardjo (LH) is an important infectious agent of reproduction pathologies and lactation decline in cattle, with a possible zoonotic role. To figure out the potential zoonotic risk for human raw-milk consumption, the present study aims at assessing the persistence and viability of LH in refrigerated raw milk over a 10-day period, which is set as the maximum time range for raw-milk domestic consumption. A negative sample of fresh raw milk was contaminated with an LH strain (2 × 108 Leptospires/mL) and analyzed by a rrs (16S) gene targeting real-time PCR (rPCR) protocol for LH DNA at days 1, 2, 3, 6, 7, 9, and 10. Seven aliquots of the same sampling time were inoculated into a semisolid EMJH media for bacterial culture. All aliquots tested positive in both rPCR and culture, which demonstrates that raw milk does not alter the detectability and viability of LH, respectively. The analytical sensitivity (LoD, limit of detection) determined for the rPCR (103 Leptospires/mL) was repeatable during the study, whereas it gradually decreased when it came to the bacterial culture. This study demonstrates that bovine raw milk might be a potential vehicle of infection by LH, even when storage conditions are strictly respected.
The Assessment and the Within-Plant Variation of the Morpho-Physiological Traits and VOCs Profile in Endemic and Rare Salvia ceratophylloides Ard. (Lamiaceae)
Authors: Vescio Rosa , Abenavoli Maria Rosa , Araniti Fabrizio , Musarella Carmelo Maria , Sofo Adriano , Laface Valentina Lucia Astrid , Spampinato Giovanni , Sorgonà Agostino
Published: March 2021

Salvia ceratophylloides (Ard.) is an endemic and rare plant species recently rediscovered as very few individuals at two different Southern Italy sites. The study of within-plant variation is fundamental to understand the plant adaptation to the local conditions, especially in rare species, and consequently to preserve plant biodiversity. Here, we reported the variation of the morpho-ecophysiological and metabolic traits between the sessile and petiolate leaf of S. ceratophylloides plants at two different sites for understanding the adaptation strategies for surviving in these habitats. The S. ceratophylloides individuals exhibited different net photosynthetic rate, maximum quantum yield, light intensity for the saturation of the photosynthetic machinery, stomatal conductance, transpiration rate, leaf area, fractal dimension, and some volatile organic compounds (VOCs) between the different leaf types. This within-plant morpho-physiological and metabolic variation was dependent on the site. These results provide empirical evidence of sharply within-plant variation of the morpho-physiological traits and VOCs profiles in S. ceratophylloides, explaining the adaptation to the local conditions.
Transcriptional Regulation of Genes Involved in Zinc Uptake, Sequestration and Redistribution Following Foliar Zinc Application to Medicago sativa
Authors: Cardini Alessio , Pellegrino Elisa , White Philip J. , Mazzolai Barbara , Mascherpa Marco C. , Ercoli Laura
Published: March 2021

Zinc (Zn) is an essential micronutrient for plants and animals, and Zn deficiency is a widespread problem for agricultural production. Although many studies have been performed on biofortification of staple crops with Zn, few studies have focused on forages. Here, the molecular mechanisms of Zn transport in alfalfa (Medicago sativa L.) were investigated following foliar Zn applications. Zinc uptake and redistribution between shoot and root were determined following application of six Zn doses to leaves. Twelve putative genes encoding proteins involved in Zn transport (MsZIP1-7, MsZIF1, MsMTP1, MsYSL1, MsHMA4, and MsNAS1) were identified and changes in their expression following Zn application were quantified using newly designed RT-qPCR assays. These assays are the first designed specifically for alfalfa and resulted in being more efficient than the ones already available for Medicago truncatula (i.e., MtZIP1-7 and MtMTP1). Shoot and root Zn concentration was increased following foliar Zn applications ≥ 0.1 mg plant−1. Increased expression of MsZIP2, MsHMA4, and MsNAS1 in shoots, and of MsZIP2 and MsHMA4 in roots was observed with the largest Zn dose (10 mg Zn plant−1). By contrast, MsZIP3 was downregulated in shoots at Zn doses ≥ 0.1 mg plant−1. Three functional gene modules, involved in Zn uptake by cells, vacuolar Zn sequestration, and Zn redistribution within the plant, were identified. These results will inform genetic engineering strategies aimed at increasing the efficiency of crop Zn biofortification.
Ongoing Evolution in the Genus Crocus: Diversity of Flowering Strategies on the Way to Hysteranthy
Authors: Pastor-Férriz Teresa , De-los-Mozos-Pascual Marcelino , Renau-Morata Begoña , Nebauer Sergio G. , Sanchis Enrique , Busconi Matteo , Fernández José-Antonio , Kamenetsky Rina , Molina Rosa V.
Published: March 2021

Species of the genus Crocus are found over a wide range of climatic areas. In natural habitats, these geophytes diverge in the flowering strategies. This variability was assessed by analyzing the flowering traits of the Spanish collection of wild crocuses, preserved in the Bank of Plant Germplasm of Cuenca. Plants of the seven Spanish species were analyzed both in their natural environments (58 native populations) and in common garden experiments (112 accessions). Differences among species observed in the native habitats were maintained under uniform environmental conditions, suggesting a genetic basis for flowering mechanisms. Two eco-morphological types, autumn- and spring-flowering species, share similar patterns of floral induction and differentiation period in summer. The optimal temperature for this process was 23 °C for both types. Unlike Irano-Turanian crocuses, spring-flowering Spanish species do not require low winter temperatures for flower elongation. Hysteranthous crocuses flower in autumn prior to leaf elongation. We conclude that the variability in flowering traits in crocuses is related to the genetic and environmental regulation of flower primordia differentiation and elongation prior to emergence above the soil surface. The elucidation of the physiological differences between eco-morphological types of crocuses: synanthous with cold requirements and synanthous and hysteranthous without cold requirements, unlocks a new approach to the flowering evolution of geophytes in Mediterranean regions. Crocus species can serve both as a new model in the study of the molecular basis of hysteranthy and for the purposes of developing the molecular markers for desirable flowering traits.
Assessment of Chlorella sorokiniana Growth in Anaerobic Digester Effluent
Authors: Ziganshina Elvira E. , Bulynina Svetlana S. , Ziganshin Ayrat M.
Published: March 2021

Microalgae are considered a potential source of valuable compounds for multiple purposes and are potential agents for bioremediation of aquatic environments contaminated with different pollutants. This work evaluates the use of agricultural waste, unsterilized and anaerobically digested, to produce biomass from a strain of Chlorella sorokiniana. Furthermore, the presence of bacteria in these wastes was investigated based on the bacterial 16S rRNA gene sequencing. The results showed a specific growth rate ranging between 0.82 and 1.45 day−1, while the final biomass yield in different digestate-containing treatments (bacterial-contaminated cultures) ranged between 0.33 and 0.50 g L−1 day−1. Besides, substantial amounts of ammonium, phosphate, and sulfate were consumed by C. sorokiniana during the experimental period. The predominant bacteria that grew in the presence of C. sorokiniana in the effluent-containing treatments belonged to the genera Chryseobacterium, Flavobacterium, Sphingomonas, Brevundimonas, Hydrogenophaga, Sphingobacterium, and Pseudomonas. Therefore, this microalga can tolerate and grow in the presence of other microorganisms. Finally, these results show that anaerobically digested agricultural waste materials are a good substitute for growth media for green microalgae; however, phosphate and sulfate levels must also be controlled in the media to maintain adequate growth of microalgae.