bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel nonsense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9
Authors: Indellicato Rossella , Domenighini Ruben , Malagolini Nadia , Cereda Anna , Mamoli Daniela , Pezzani Lidia , Iascone Maria , dall’Olio Fabio , Trinchera Marco
Published: October 2019

Three missense variants of ST3GAL3 are known to be responsible for a congenital disorder of glycosylation determining a neurodevelopmental disorder (intellectual disability/epileptic encephalopathy). Here we report a novel nonsense variant, p.Y220*, in two dichorionic infant twins presenting a picture of epileptic encephalopathy with impaired neuromotor development. Upon expression in HEK-293T cells, the variant appears totally devoid of enzymatic activity in vitro, apparently accumulated with respect to the wild-type or the missense variants, as detected by western blot, and in large part properly localized in the Golgi apparatus, as assessed by confocal microscopy. Both patients were found to efficiently express the CA19.9 antigen in the serum despite the total loss of ST3GAL3 activity, which thus appears replaceable from other ST3GALs in the synthesis of the sialyl-Lewis a epitope. Kinetic studies of ST3GAL3 revealed a strong preference for lactotetraosylceramide as acceptor and gangliotetraosylceramide was also efficiently utilized in vitro. Moreover, the p.A13D missense variant, the one maintaining residual sialyltransferase activity, was found to have much lower affinity for all suitable substrates than the wild-type enzyme with an overall catalytic efficiency almost negligible. Altogether the present data suggest that the apparent redundancy of ST3GALs deduced from knock-out mouse models only partially exists in humans. In fact, our patients lacking ST3GAL3 activity synthesize the CA19.9 epitope sialyl-Lewis a, but not all glycans necessary for fine brain functions, where the role of minor gangliosides deserves further attention.
Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution
Authors: Yang Tong , Yao Yuan , Wang Xing , Li Yuying , Si Yunlong , Li Xumin , Ayala Gabriela Jaramillo , Wang Yue , Mayo Kevin H , Tai Guihua , Zhou Yifa , Su Jiyong
Published: October 2019

Galectin-13 (Gal-13) plays numerous roles in regulating the relationship between maternal and fetal tissues. Low expression levels or mutations of the lectin can result in pre-eclampsia. The previous crystal structure and gel filtration data show that Gal-13 dimerizes via formation of two disulfide bonds formed by Cys136 and Cys138. In the present study, we mutated them to serine (C136S, C138S and C136S/C138S), crystalized the variants and solved their crystal structures. All variants crystallized as monomers. In the C136S structure, Cys138 formed a disulfide bond with Cys19, indicating that Cys19 is important for regulation of reversible disulfide bond formation in this lectin. Hemagglutination assays demonstrated that all variants are inactive at inducing erythrocyte agglutination, even though gel filtration profiles indicate that C136S and C138S could still form dimers, suggesting that these dimers do not exhibit the same activity as wild-type (WT) Gal-13. In HeLa cells, the three variants were found to be distributed the same as with WT Gal-13. However, a Gal-13 variant (delT221) truncated at T221 could not be transported into the nucleus, possibly explaining why women having this variant get pre-eclampsia. Considering the normally high concentration of glutathione in cells, WT Gal-13 should exist mostly as a monomer in cytoplasm, consistent with the monomeric variant C136S/C138S, which has a similar ability to interact with HOXA1 as WT Gal-13.
N-glycosylation of the CmeABC multidrug efflux pump is needed for optimal function in Campylobacter jejuni
Authors: Dubb Rajinder K , Nothaft Harald , Beadle Bernadette , Richards Michele R , Szymanski Christine M
Published: October 2019

Campylobacter jejuni is a prevalent gastrointestinal pathogen associated with increasing rates of antimicrobial resistance development. It was also the first bacterium demonstrated to possess a general N-linked protein glycosylation pathway capable of modifying > 80 different proteins, including the primary Campylobacter multidrug efflux pump, CmeABC. Here we demonstrate that N-glycosylation is necessary for the function of the efflux pump and may, in part, explain the evolutionary pressure to maintain this protein modification system. Mutants of cmeA in two common wildtype (WT) strains are highly susceptible to erythromycin (EM), ciprofloxacin and bile salts when compared to the isogenic parental strains. Complementation of the cmeA mutants with the native cmeA allele restores the WT phenotype, whereas expression of a cmeA allele with point mutations in both N-glycosylation sites is comparable to the cmeA mutants. Moreover, loss of CmeA glycosylation leads to reduced chicken colonization levels similar to the cmeA knock-out strain, while complementation fully restores colonization. Reconstitution of C. jejuni CmeABC into Escherichia coli together with the C. jejuni N-glycosylation pathway increases the EM minimum inhibitory concentration and decreases ethidium bromide accumulation when compared to cells lacking the pathway. Molecular dynamics simulations reveal that the protein structures of the glycosylated and non-glycosylated CmeA models do not vary from one another, and in vitro studies show no change in CmeA multimerization or peptidoglycan association. Therefore, we conclude that N-glycosylation has a broader influence on CmeABC function most likely playing a role in complex stability.
10. Sampling
Authors: Clark Tom , Foster Liam , Bryman Alan
Published: October 2019

Whether the research project adopts a quantitative, qualitative, or mixed strategy, there is little point in asking a few non-random people a few non-random questions as the student has no idea what those answers might indicate, or whether they might apply in other situations. Therefore, the student needs to think carefully about his or her sampling strategy and justify this in the dissertation. This chapter explains the key principles of probability and non-probability sampling and explores why ‘who’ is asked is just as important as ‘what’ is asked. It discusses the two key stages of sampling: defining the appropriate population for study and developing strategies for recruiting the sample.
16. Evaluating Your Project
Authors: Clark Tom , Foster Liam , Bryman Alan
Published: October 2019

Critical reflection is a key part of evaluating the research project, and a dissertation that demonstrates this is likely to achieve higher marks. However, one of the first things to recognize is that the process of evaluation does not necessarily begin at the end of the project. Instead, issues of research quality are implicitly embedded in all parts of the research process and all sections of the dissertation. This chapter introduces some key criteria that will help students evaluate their project and think critically about the research process. It discusses the importance of originality, rigour, and significance in research, and provides key questions students can ask about their project. Collectively, these questions will help students to assess and evaluate their research.
The RxHL study: community-responsive research to explore barriers to medication adherence
Authors: Shaw Susan J , Korchmaros Josephine D , Huebner Torres Cristina , Totman Molly S , Lee Jeannie K
Published: October 2019

This study aims to contribute to the development of community-responsive research approaches by describing the research methods used in the RxHL study and the interprofessional and community-based collaboration that produced them. The mixed-method RxHL study was developed in close consultation with staff and providers at our research site, a federally qualified health center in Springfield, MA. We utilized quantitative methods including chart review, manual pill counts and self-report surveys to assess factors associated with medication adherence in a diverse population of low-income patients with chronic disease. We triangulated these results with findings from qualitative methods that included in-depth interviews, home visits and chronic disease diaries. We used the constant comparison method and interdisciplinary, participatory team meetings to integrate quantitative and qualitative findings. A community-responsive approach facilitated the recruitment and retention of a diverse sample of patients. Self-report surveys revealed the widespread scope of barriers to care such as medication costs and transportation, and limited health literacy among diverse groups. Qualitative research methods offered a deeper understanding of the social and environmental contexts in which medication adherence takes place. Prioritizing the needs of community partners and research participants facilitates rigorous data collection in clinical settings with maximum participation from community partners.
Environmental controls and anthropogenic impacts on deep-sea sponge grounds in the Faroe-Shetland Channel, NE Atlantic: the importance of considering spatial scale to distinguish drivers of change
Authors: Vad J , Kazanidis G , Henry L-A , Jones D O B , Gates A R , Roberts J M
Published: October 2019

Determining the scale of anthropogenic impacts is critical in order to understand ecosystem effects of human activities, within the context of changes caused by natural environmental variability. We applied spatial eigenfunction analysis to disentangle effects of anthropogenic drivers from environmental factors on species assembly in the Faroe-Shetland Channel (FSC), in the northeast Atlantic. We found that the species assembly considered here was structured at both small and large spatial scales. Specifically, substrate types, distance to oil wells and pipelines, the presence of objects and demersal fishing (both static and mobile) appeared significant in explaining large spatial scale species assembly structures. Conversely, temperature and variance in temperature shaped the species community across smaller spatial scales. Mobile scavenger species were found in areas impacted by demersal fishing. Oil and gas structures seemed to provide a habitat for a range of species including the commercially important fishes Molva sp. and Sebastes sp. These results demonstrate how the benthic ecosystem in the FSC has been shaped by multiple human activities, at both small and large spatial scales. Only by sampling datasets covering several sites, like in this study, can the effects of anthropogenic activities be separated from natural environmental controls.
Ecological thresholds in forecast performance for key United States West Coast Chinook salmon stocks
Authors: Satterthwaite William H , Andrews Kelly S , Burke Brian J , Gosselin Jennifer L , Greene Correigh M , Harvey Chris J , Munsch Stuart H , O’Farrell Michael R , Samhouri Jameal F , Sobocinski Kathryn L
Published: October 2019

Preseason abundance forecasts drive management of US West Coast salmon fisheries, yet little is known about how environmental variability influences forecast performance. We compared forecasts of Chinook salmon (Oncorhynchus tshawytscha) against returns for (i) key California-Oregon ocean fishery stocks and (ii) high priority prey stocks for endangered Southern Resident Killer Whales (Orcinus orca) in Puget Sound, Washington. We explored how well environmental indices (at multiple locations and time lags) explained performance of forecasts based on different methods (i.e. sibling-based, production-based, environment-based, or recent averages), testing for nonlinear threshold dynamics. For the California stocks, no index tested explained >50% of the variation in forecast performance, but spring Pacific Decadal Oscillation and winter North Pacific Index during the year of return explained >40% of the variation for the sibling-based Sacramento Fall Chinook forecast, with nonlinearity and apparent thresholds. This suggests that oceanic conditions experienced by adults (after younger siblings returned) have the most impact on sibling-based forecasts. For Puget Sound stocks, we detected nonlinear/threshold relationships explaining >50% of the variation with multiple indices and lags. Environmental influences on preseason forecasts may create biases that render salmon fisheries management more or less conservative, and therefore could motivate the development of ecosystem-based risk assessments.
Comparisons of mean length-based mortality estimators and age-structured models for six southeastern US stocks
Authors: Huynh Quang C , Cummings Nancie J , Hoenig John M
Published: October 2019

Length-based mortality estimators have been developed as alternative assessment methods for data-limited stocks. We compared mortality estimates from three methodologically related mean length-based methods to those from an age-structured model (ASM). We estimated fishing mortality and determined overfishing status, i.e. if F/FMSY > 1, for six stocks which support important recreational and commercial fisheries in the southeastern United States. The similarities in historical fishing mortality between the length-based methods and the most recent assessments varied among the case studies, but the classification of overfishing status in the terminal year did not differ based on the choice of model for all six stocks. There was also high agreement in the number of overfishing years within different historical periods. Applications of length-based methods can be consistent with the results that might be obtained from an ASM. In one case, diagnostics were used to identify the problems with the length-based estimators. The potential for determining overfishing status from these methods can encourage data collection programmes for unassessed stocks.
Clinical significance of right atrial volume in patients with repaired tetralogy of Fallot
Authors: Kido Takashi , Ueno Takayoshi , Taira Masaki , Kanaya Tomomitsu , Okuda Naoki , Toda Koichi , Kuratani Toru , Sawa Yoshiki
Published: October 2019

OBJECTIVES

Atrial arrhythmia and right ventricular (RV) diastolic dysfunction are associated with increased morbidity and mortality in patients with repaired tetralogy of Fallot (TOF). This study was performed to determine whether the preoperative right atrial (RA) volume can predict the development of atrial arrhythmia after pulmonary valve replacement (PVR) in patients with TOF.

METHODS

Forty-seven consecutive adult patients with repaired TOF underwent PVR from 2003 to 2018. Seventeen patients showed preoperative atrial arrhythmia and underwent the Maze procedure concomitantly. The preoperative RA volume was evaluated with computed tomography and image analysis software.

RESULTS

The median follow-up period after PVR was 6.8 years. Among 17 patients who underwent the Maze procedure, recurrent atrial arrhythmia developed in 8 patients. Among 30 patients without preoperative atrial arrhythmia, novel atrial arrhythmia developed in 2 patients. The RA volume index was a significant predictor according to the multivariate analysis (P = 0.003). The RA volume index showed a significant positive correlation with the RV end-diastolic pressure (P < 0.001).

CONCLUSIONS

The RA volume predicts the development of atrial arrhythmia after PVR in patients with repaired TOF. RA volume measurement is strongly recommended in the management of this patient population.

Clinical trial registration number

Institutional review board of Osaka University Hospital, number 16105.
The Role of User Comments in Estimation of the Public Opinion Climate and Perceived Support for One’s Opinion
Authors: Soffer Oren , Gordoni Galit
Published: October 2019

This article examines how user comments influence assessment of public opinion climate and perceived support for one’s opinion. The effects of user-comment sentiment (positive vs. negative) and of user-comment content (with or without personal exemplification) were tested with an online experiment (n = 1,510). Results show that user-comment effects on estimates of public opinion depend mainly on the sentiment of the comments and not on their framing as opinions with or without personal exemplification. Negative comments significantly reduce readers’ estimation of public opinion support of the issue dealt with by the article and affect the perceived support of one’s opinion. Study results refer to the possible dangers in user comments deliberate manipulation in democratic public discussion.
Toric Geometry of Spin(7)-Manifolds
Authors: Bruun Madsen Thomas , Swann Andrew
Published: October 2019

We study $ \operatorname{Spin}(7) $-manifolds with an effective multi-Hamiltonian action of a four-torus. On an open dense set, we provide a Gibbons–Hawking type ansatz that describes such geometries in terms of a symmetric $ 4\times 4 $-matrix of functions. This description leads to the 1st known $ \operatorname{Spin}(7) $-manifolds with a rank $ 4 $ symmetry group and full holonomy. We also show that the multi-moment map exhibits the full orbit space topologically as a smooth four-manifold, containing a trivalent graph in $ \mathbb{R}^4 $ as the image of the set of the special orbits.
2-torsion points on theta divisors
Authors: Pareschi Giuseppe , Salvati Manni Riccardo
Published: October 2019

In this note we prove a sharp bound for the number of 2-torsion points on a theta divisor and show that this is achieved only in the case of products of elliptic curves. This settles in the affirmative a conjecture of Marcucci and Pirola.
Hyperboloidal Similarity Coordinates and a Globally Stable Blowup Profile for Supercritical Wave Maps
Authors: Biernat Paweł , Donninger Roland , Schörkhuber Birgit
Published: October 2019

We consider co-rotational wave maps from (1+3)-dimensional Minkowski space into the three-sphere. This model exhibits an explicit blowup solution, and we prove the asymptotic nonlinear stability of this solution in the whole space under small perturbations of the initial data. The key ingredient is the introduction of a novel coordinate system that allows one to track the evolution past the blowup time and almost up to the Cauchy horizon of the singularity. As a consequence, we also obtain a result on continuation beyond blowup.
Dimensional Bounds for Ancient Caloric Functions on Graphs
Authors: Hua Bobo
Published: October 2019

We study ancient solutions of polynomial growth to heat equations on graphs and extend Colding and Minicozzi’s theorem [9] on manifolds to graphs: for a graph of polynomial volume growth, the dimension of the space of ancient solutions of polynomial growth is bounded by the product of the growth degree and the dimension of harmonic functions with the same growth.
Multiplicity of Asymptomatic Plasmodium falciparum Infections and Risk of Clinical Malaria: A Systematic Review and Pooled Analysis of Individual Participant Data
Authors: Eldh Martina , Hammar Ulf , Arnot David , Beck Hans-Peter , Garcia André , Liljander Anne , Mercereau-Puijalon Odile , Migot-Nabias Florence , Mueller Ivo , Ntoumi Francine , Ross Amanda , Smith Thomas , Sondén Klara , Vafa Homann Manijeh , Yman Victor , Felger Ingrid , Färnert Anna
Published: October 2019

Background

The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity in asymptomatic P. falciparum infections—that is, the number of coinfecting clones—affects the subsequent risk of clinical malaria in populations living under different levels of transmission.

Methods

A systematic search of the literature was performed to identify studies in which P. falciparum infections were genotyped in asymptomatic individuals who were followed up prospectively regarding the incidence of clinical malaria. Individual participant data were pooled from 15 studies (n = 3736 individuals).

Results

Multiclonal asymptomatic infections were associated with a somewhat increased subsequent risk of clinical malaria in the youngest children, followed by an initial declining risk with age irrespective of transmission intensity. At approximately 5 years of age, the risk continued the gradual decline with age in high-transmission settings. However, in older children in moderate-, low-, and seasonal-transmission settings, multiclonal infections were either not significantly associated with the risk of subsequent febrile malaria or were associated with an increased risk.

Conclusions

The number of clones in asymptomatic P. falciparum infections is associated with different risks of subsequent clinical malaria depending on age and transmission intensity.
A randomized, double-blind trial investigating the efficacy of caspofungin versus amphotericin B deoxycholate in the treatment of invasive candidiasis in neonates and infants younger than 3 months of age
Authors: Kim Jason , Nakwa Firdose Lambey , Araujo Motta Fábio , Liu Hong , Dorr Mary Beth , Anderson Leah J , Kartsonis Nicholas
Published: October 2019

Objectives

Investigate the efficacy of caspofungin in participants <3 months of age with invasive Candida infection (ICI).

Methods

This multicentre, randomized, double-blind, comparator-controlled, Phase 2 study (protocol MK0991-064; NCT01945281) enrolled participants <3 months of age with culture-confirmed ICI within 96 h of study entry. Participants were randomly assigned 2:1 to once-daily intravenous 2 mg/kg caspofungin or intravenous 1 mg/kg amphotericin B deoxycholate (dAMB). The primary endpoint was fungal-free survival (FFS) 2 weeks after treatment in the full-analysis-set (FAS) population, defined as participants with culture-confirmed ICI who received ≥1 dose of therapy. Planned enrolment was 90 participants.

Results

Fifty-one participants were enrolled; 49 received treatment (caspofungin, n=33; dAMB, n=16); 2 additional participants did not have confirmed infections at study entry. The study was terminated after ∼ 3.5 years because of low enrolment. Forty-seven participants were included in the FAS population (caspofungin, n=31; dAMB, n=16). FFS rate at 2 weeks after treatment was 71.0% (22/31) in the caspofungin arm and 68.8% (11/16) in the dAMB arm [difference, stratified by weight, − 0.9% (95% CI, − 24.3%–27.7%)]. Adverse events developed in 84.8% (28/33) of participants in the caspofungin arm and 100% (16/16) in the dAMB arm.

Conclusions

Among neonates and infants with confirmed ICI, FFS at 2 weeks was similar in the caspofungin and dAMB treatment arms. A smaller proportion of participants who received caspofungin experienced adverse events.
Adaptive Radiation Genomics of Two Ecologically Divergent Hawai‘ian Honeycreepers: The ‘akiapōlā‘au and the Hawai‘i ‘amakihi
Authors: Campana Michael G , Corvelo André , Shelton Jennifer , Callicrate Taylor E , Bunting Karen L , Riley-Gillis Bridget , Wos Frank , DeGrazia Justin , Jarvis Erich D , Fleischer Robert C
Published: October 2019

The Hawai‘ian honeycreepers (drepanids) are a classic example of adaptive radiation: they adapted to a variety of novel dietary niches, evolving a wide range of bill morphologies. Here we investigated genomic diversity, demographic history, and genes involved in bill morphology phenotypes in 2 honeycreepers: the ‘akiapōlā‘au (Hemignathus wilsoni) and the Hawai‘i ‘amakihi (Chlorodrepanis virens). The ‘akiapōlā‘au is an endangered island endemic, filling the “woodpecker” niche by using a unique bill morphology, while the Hawai‘i ‘amakihi is a dietary generalist common on the islands of Hawai‘i and Maui. We de novo sequenced the ‘akiapōlā‘au genome and compared it to the previously sequenced ‘amakihi genome. The ‘akiapōlā‘au is far less heterozygous and has a smaller effective population size than the ‘amakihi, which matches expectations due to its smaller census population and restricted ecological niche. Our investigation revealed genomic islands of divergence, which may be involved in the honeycreeper radiation. Within these islands of divergence, we identified candidate genes (including DLK1, FOXB1, KIF6, MAML3, PHF20, RBP1, and TIMM17A) that may play a role in honeycreeper adaptations. The gene DLK1, previously shown to influence Darwin’s finch bill size, may be related to honeycreeper bill morphology evolution, while the functions of the other candidates remain unknown.
Beyond Rational Choice: International Trade Law and The Behavioral Political Economy of Protectionism
Authors: van Aaken Anne , Kurtz Jürgen
Published: October 2019

The classic political economy of trade models state behavior on the international plane by reference to the formation of domestic interests. Voters, interest groups, and politicians are rational actors in this model, pursuing their economic preferences without cognitive or motivational distortions. This article questions the sufficiency of the rational choice model in the formation of contemporary trade policy. Starting from the classic political economy story, this article explores real-world deviations from rationally expected outcomes by drawing on cognitive psychology. Using both theoretical and empirical analysis, we seek to identify key distortions that can better explain voter and politician behavior in the current trade wars. We begin with loss aversion in that individuals have asymmetrical attitudes towards gains and losses. Rising inequality within the rich world amounts to a perceived relative loss particularly for middle-class citizens. Combined with the absolute rise of equality between countries, this can trigger a double loss frame—both as an individual loss and a national loss—that can profoundly shape anti-trade preferences in certain countries. Framing trade as a security threat also invokes powerful hawkish biases. Lastly, the availability bias can be provoked by social media mechanisms making people tend to focus on particular risks and overweight their import.
Atomistic and dynamic structural characterizations in low-dimensional materials: recent applications of in situ transmission electron microscopy
Authors: Zheng He , Cao Fan , Zhao Ligong , Jiang Renhui , Zhao Peili , Zhang Ying , Wei Yanjie , Meng Shuang , Li Kaixuan , Jia Shuangfeng , Li Luying , Wang Jianbo
Published: October 2019

In situ transmission electron microscopy has achieved remarkable advances for atomic-scale dynamic analysis in low-dimensional materials and become an indispensable tool in view of linking a material’s microstructure to its properties and performance. Here, accompanied with some cutting-edge researches worldwide, we briefly review our recent progress in dynamic atomistic characterization of low-dimensional materials under external mechanical stress, thermal excitations and electrical field. The electron beam irradiation effects in metals and metal oxides are also discussed. We conclude by discussing the likely future developments in this area.
Mapping the Global Cancer Research Funding Landscape
Authors: Schmutz Anna , Salignat Claire , Plotkina Daria , Devouassoux Amandine , Lee Teresa , Arnold Melina , Ervik Morten , Kelm Olaf
Published: October 2019

Background

Global investment in research on noncommunicable diseases is on the rise. Cancer as primus inter pares draws particular interest from a wide spectrum of research funders. Next to the private, governmental, and academic sectors, philanthropy has carved out a sizeable area in the funding landscape over the last 25 years. Previous reports describing cancer research funding have looked at the volume of investment in cancer research but have paid little attention to building strategic intelligence on funders. Moreover, these efforts have focused primarily on well-resourced organizations, neglecting a large number of players with less-developed finances.

Methods

In this article, we combined gnostic data acquisition with agnostic bibliometrics to establish a comprehensive map of the global cancer research funding landscape. The analysis of funding acknowledgments from cancer research papers used in this exercise is a “bottom-up” method that provides a broader perspective on the variety of actors involved. It does not rely on a priori knowledge, nor does it require funders’ support for access to the data.

Results

Using this approach, we have identified a total of 4693 organizations from 107 countries engaged in funding cancer research today.

Conclusions

This is the largest mapping exercise performed to date and should serve as a knowledge base for future analyses and comparisons aimed at understanding the dynamics and priorities of global cancer research funding.
The Contributions of Illness Stigma, Health Communication Difficulties, and Thwarted Belongingness to Depressive Symptoms in Youth with Inflammatory Bowel Disease
Authors: Roberts Caroline M , Gamwell Kaitlyn L , Baudino Marissa N , Grunow John E , Jacobs Noel J , Tung Jeanne , Gillaspy Stephen R , Hommel Kevin A , Mullins Larry L , Chaney John M
Published: October 2019

Objective

Youth with inflammatory bowel disease (IBD) often experience difficulties communicating about their disease. It is suspected that the stigmatizing nature of IBD symptoms contributes to youths’ health communication difficulties, leaving youth feeling disconnected from their social environment and potentially resulting in decreased social belongingness and poorer emotional functioning. In this study, we tested an illness stigma → health communication difficulties → thwarted belongingness → depressive symptoms serial mediation model. It was anticipated that youth illness stigma would confer a serial indirect effect on youth depressive symptoms through the sequential effects of stigma on health communication difficulties and thwarted social belongingness.

Methods

Seventy-five youth with IBD between the ages of 10 and 18 completed measures of perceived illness stigma, health communication difficulties, thwarted belongingness, and depressive symptoms.

Results

Results indicated a significant illness stigma → thwarted belongingness → depressive symptoms simple mediation path. Importantly, findings also revealed a significant serial mediation path for illness stigma → health communication difficulties → thwarted belongingness → depressive symptoms.

Conclusions

Youth who perceive greater IBD stigma appear to experience increased difficulty communicating about their IBD with others, which in turn is associated with feelings of thwarted social belongingness and ultimately elevated depressive symptoms. These findings suggest that difficulty communicating about IBD is one potential route by which illness stigma has a negative impact on youth adjustment outcomes. Results could also inform clinical interventions to address IBD stigma and health communication difficulties associated with the social and emotional challenges in youth with IBD.
Laparoscopic repair of interparietal abdominal wall hernias
Authors: Kalmar Christopher L , Bower Curtis E
Published: October 2019

Interparietal hernias are rare abdominal defects where intraabdominal contents protrude between layers of the abdominal wall. There is limited experience using laparoscopic technique for repairing substantially large interparietal hernias. Computed tomography scans of both cases herein demonstrated intact external oblique, but the internal oblique and transversus abdominis were widely detached from the linea semilunaris. Our experience demonstrates the largest interparietal hernias treated entirely with laparoscopic repair, which successfully resolved symptoms and abdominal wall irregularity, as well as allowed discharge on the first postoperative day without complication.
Collectives in the Qur'Ān Revisited: Another Possibility of Semantic Agreement
Authors: D'Anna Luca
Published: October 2019

The present paper revisits Dror's (2016a) analysis of collective nouns and their agreement patterns in the Qur'ān. Collectives are ‘unmarked plurals’, i.e. morphologically singular nouns that semantically refer to a plurality of entities. With respect to agreement, Dror distinguishes between singular agreement (syntactic) and plural agreement (semantic), signalling respectively a holistic or distributive reference. We argue that, although the consideration of plural agreement as semantically motivated is correct, gender should also be taken into consideration, especially when a mismatch occurs between morphologically masculine singular collectives and feminine singular agreeing targets. The present paper, grounded in a typological approach, demonstrates that feminine singular agreement with masculine singular controllers represents another form of semantic agreement, in which the controller is considered as a non-individuated plural.
Analysing headlines as a way of downsizing news corpora: Evidence from an Arabic–English comparable corpus of newspaper articles
Authors: Haider Ahmad S , Hussein Riyad F
Published: October 2019

This study examines whether a qualitative analysis of news headlines produces complementary, convergent, or dissonant findings with a quantitative analysis of the full news story. Headlines are among the most important parts of a news story and its summary. This study investigates the construction of Qaddafi in the headlines of two newspapers before and during the 2011 Libyan civil war. This is based on a sub-corpus of headlines that was taken from a 6.5-million-word corpus of two newspapers; one published in English; The Guardian, and the other in Arabic; Asharq Al-Awsat from 2009 to 2011. The analysis of the headlines has produced complementary and convergent findings with the corpus analysis and suggests that the 2011 Libyan civil war represents a turning point on how Qaddafi is represented in the investigated newspapers. This study concludes that analysing headlines proves to be a good down-sampling option to reduce large news corpora to a workable amount of data.
On the weak magnetic field of millisecond pulsars: does it decay before accretion?
Authors: Cruces Marilyn , Reisenegger Andreas , Tauris Thomas M
Published: October 2019

Millisecond pulsars (MSPs) are old, fast spinning neutron stars (NSs) thought to have evolved from classical pulsars in binary systems, where the rapid rotation is caused by the accretion of matter and angular momentum from their companion. During this transition between classical and MSPs, there is a magnetic field reduction of ∼4 orders of magnitude, which is not well understood. According to the standard scenario, the magnetic field is reduced as a consequence of accretion, either through ohmic dissipation or through screening by the accreted matter. We explored an alternative hypothesis in which the magnetic field is reduced through ambipolar diffusion before the accretion. This is particularly effective during the long epoch in which the pulsar has cooled, but has not yet started accreting. This makes the final magnetic field dependent on the evolution time of the companion star and thus its initial mass. We use observed binary systems to constrain the time available for the magnetic field decay based on the current pulsar companion: a helium white dwarf, a carbon–oxygen white dwarf, or another NS. Based on a simplified model without baryon pairing, we show that the proposed process agrees with the general distribution of observed magnetic field strengths in binaries, but is not able to explain some mildly recycled pulsars where no significant decay appears to have occurred. We discuss the possibility of other formation channels for these systems and the conditions under which the magnetic field evolution would be set by the NS crust rather than the core.
Young star cluster populations in the E-MOSAICS simulations
Authors: Pfeffer Joel , Bastian Nate , Kruijssen J M Diederik , Reina-Campos Marta , Crain Robert A , Usher Christopher
Published: October 2019

We present an analysis of young star clusters (YSCs) that form in the E-MOSAICS cosmological, hydrodynamical simulations of galaxies and their star cluster populations. Through comparisons with observed YSC populations, this work aims to test models for YSC formation and obtain an insight into the formation processes at work in part of the local galaxy population. We find that the models used in E-MOSAICS for the cluster formation efficiency and high-mass truncation of the initial cluster mass function ($M_\rm {c,\ast }$) both quantitatively reproduce the observed values of cluster populations in nearby galaxies. At higher redshifts (z ≥ 2, near the peak of globular cluster formation) we find that, at a constant star formation rate (SFR) surface density, $M_\rm {c,\ast }$ is larger than at z = 0 by a factor of four due to the higher gas fractions in the simulated high-redshift galaxies. Similar processes should be at work in local galaxies, offering a new way to test the models. We find that cluster age distributions may be sensitive to variations in the cluster formation rate (but not SFR) with time, which may significantly affect their use in tests of cluster mass-loss. By comparing simulations with different implementations of cluster formation physics, we find that (even partially) environmentally independent cluster formation is inconsistent with the brightest cluster-SFR and specific luminosity-$\Sigma _\rm {SFR}$ relations, whereas these observables are reproduced by the fiducial, environmentally varying model. This shows that models in which a constant fraction of stars form in clusters are inconsistent with observations.
Studying high-z galaxies with [C ii]  intensity mapping
Authors: Yue B , Ferrara A
Published: October 2019

We investigate the [C ii] line intensity mapping (IM) signal from galaxies in the Epoch of Reionization (EoR) to assess its detectability, the possibility to constrain the $L_{\rm C\,{\small II}}\!-\!{\rm SFR}$ relation, and to recover the [C ii] luminosity function (LF) from future experiments. By empirically assuming that ${\rm log}\,L_{\rm C\,{\small II}}={\rm log}\,A+\gamma {\rm SFR}\pm \sigma _\mathrm{ L}$, we derive the [C ii] LF from the observed UV LF, and the [C ii] IM power spectrum. We study the shot noise and the full power spectrum separately. Although, in general, the shot-noise component has a much higher signal-to-noise ratio than the clustering one, it cannot be used to put independent constraints on log A and γ. Full power spectrum measurements are crucial to break such degeneracy and reconstruct the [C ii] LF. In our fiducial survey S1 (inspired by CCAT-p/1000 h) at z ∼ 6, the shot-noise (clustering) signal is detectable for two (one) of the five considered $L_{\rm C\,{\small II}}\!-\!{\rm SFR}$ relations. The shot noise is generally dominated by galaxies with $L_{\rm C\,{\small II}}\gtrsim 10^{8}\!-\!10^{9}~ \mathrm{L}_\odot$ (MUV ∼ −20 to −22), already at reach of ALMA pointed observations. However, given the small field of view of such telescope, an IM experiment would provide unique information on the bright end of the LF. The detection depth of an IM experiment crucially depends on the (poorly constrained) $L_{\rm C\,{\small II}}\!-\!{\rm SFR}$ relation in the EoR. If the $L_{\rm C\,{\small II}}\!-\!{\rm SFR}$ relation varies in a wide log A–γ range, but still consistent with ALMA [C ii] LF upper limits, even the signal from galaxies with $L_{\rm C\,{\small II}}$ as faint as ∼107 L⊙ could be detectable. Finally, we consider the contamination by continuum foregrounds (cosmic infrared background, dust, cosmic microwave background) and CO interloping lines, and derive the requirements on the residual contamination level to reliably extract the [C ii] signal.
Instability of twisted magnetar magnetospheres
Authors: Mahlmann J F , Akgün T , Pons J A , Aloy M A , Cerdá-Durán P
Published: October 2019

We present 3D force-free electrodynamics simulations of magnetar magnetospheres that demonstrate the instability of certain degenerate, high energy equilibrium solutions of the Grad–Shafranov equation. This result indicates the existence of an unstable branch of twisted magnetospheric solutions and allows us to formulate an instability criterion. The rearrangement of magnetic field lines as a consequence of this instability triggers the dissipation of up to 30 per cent of the magnetospheric energy on a thin layer above the magnetar surface. During this process, we predict an increase of the mechanical stresses on to the stellar crust, which can potentially result in a global mechanical failure of a significant fraction of it. We find that the estimated energy release and the emission properties are compatible with the observed giant flare events. The newly identified instability is a candidate for recurrent energy dissipation, which could explain part of the phenomenology observed in magnetars.
Towards an understanding of the resolution dependence of Core-Collapse Supernova simulations
Authors: Nagakura Hiroki , Burrows Adam , Radice David , Vartanyan David
Published: October 2019

Using our new state-of-the-art core-collapse supernova (CCSN) code Fornax, we explore the dependence upon spatial resolution of the outcome and character of three-dimensional (3D) supernova simulations. For the same 19 M⊙ progenitor star, energy and radial binning, neutrino microphysics, and nuclear equation of state, changing only the number of angular bins in the θ and ϕ directions, we witness that our lowest resolution 3D simulation does not explode. However, when jumping progressively up in resolution by factors of two in each angular direction on our spherical-polar grid, models then explode, and explode slightly more vigorously with increasing resolution. This suggests that there can be a qualitative dependence of the outcome of 3D CCSN simulations upon spatial resolution. The critical aspect of higher spatial resolution is the adequate capturing of the physics of neutrino-driven turbulence, in particular its Reynolds stress. The greater numerical viscosity of lower resolution simulations results in greater drag on the turbulent eddies that embody turbulent stress, and, hence, in a diminution of their vigor. Turbulent stress not only pushes the temporarily stalled shock further out, but bootstraps a concomitant increase in the deposited neutrino power. Both effects together lie at the core of the resolution dependence we observe.
Global hierarchical collapse in molecular clouds. Towards a comprehensive scenario
Authors: Vázquez-Semadeni Enrique , Palau Aina , Ballesteros-Paredes Javier , Gómez Gilberto C , Zamora-Avilés Manuel
Published: October 2019

We present a unified description of the scenario of global hierarchical collapse (GHC). GHC constitutes a flow regime of (non-homologous) collapses within collapses, in which all scales accrete from their parent structures, and small, dense regions begin to contract at later times, but on shorter time-scales than large, diffuse ones. The different time-scales allow for most of the clouds’ mass to be dispersed by the feedback from the first massive stars, maintaining the cloud-scale star formation rate low. Molecular clouds (MCs), clumps, and cores are not in equilibrium, but rather are either undergoing contraction or dispersal. The main features of GHC are as follows: (1) The gravitational contraction is initially very slow, and begins when the cloud still consists of mostly atomic gas. (2) Star-forming MCs are in an essentially pressureless regime, causing filamentary accretion flows from the cloud to the core scale to arise spontaneously. (3) Accreting objects have longer lifetimes than their own free-fall time, due to the continuous replenishment of material. (4) The clouds’ total mass and its molecular and dense mass fractions increase over time. (5) The clouds’ masses stop growing when feedback becomes important. (6) The first stars appear several megayears after global contraction began, and are of low mass; massive stars appear a few megayears later, in massive hubs. (7) The minimum fragment mass may well extend into the brown-dwarf regime. (8) Bondi–Hoyle–Lyttleton-like accretion occurs at both the protostellar and the core scales, accounting for an IMF with slope dN/dM ∝ M−2. (9) The extreme anisotropy of the filamentary network explains the difficulty in detecting large-scale infall signatures. (10) The balance between inertial and gravitationally driven motions in clumps evolves during the contraction, explaining the approach to apparent virial equilibrium, from supervirial states in low-column density clumps and from subvirial states in dense cores. (11) Prestellar cores adopt Bonnor–Ebert-like profiles, but are contracting ever since when they may appear to be unbound. (12) Stellar clusters develop radial age and mass segregation gradients. We also discuss the incompatibility between supersonic turbulence and the observed scalings in the molecular hierarchy. Since gravitationally formed filaments do not develop shocks at their axes, we suggest that a diagnostic for the GHC scenario should be the absence of strong shocks in them. Finally, we critically discuss some recent objections to the GHC mechanism.
The thermal-radiative wind in low-mass X-ray binary H1743−322: radiation hydrodynamic simulations
Authors: Tomaru Ryota , Done Chris , Ohsuga Ken , Nomura Mariko , Takahashi Tadayuki
Published: October 2019

Blueshifted absorption lines are seen in high inclination black hole binary systems in their disc-dominated states, showing these power an equatorial disc wind. While some contribution from magnetic winds remain a possibility, thermal and thermal-radiative winds are expected to be present. We show results from radiation hydrodynamic simulations that show that the additional radiation force from atomic features (bound–free and lines) is important along with electron scattering. Together, these increase the wind velocity at high inclinations, so that they quantitatively match the observations in H1743−322, unlike purely thermal winds that are too slow. We highlight the role played by shadowing of the outer disc from the (subgrid) inner disc Compton heated layer, and show that the increase in shadow from the higher Compton temperature after the spectral transition to the hard state leads to strong suppression of the wind. Thermal-radiative winds explain all of the spectral features (and their disappearance) in this simplest wind system and magnetic winds play only a minor role. We speculate that thermal-radiative winds can explain all the spectral features seen in the more complex (larger disc size) binaries, GRO J1655−40 and GRS 1915+105, without requiring magnetic winds.
How much graphene in space?
Authors: Li Qi , Li Aigen , Jiang B W
Published: October 2019

The possible presence of graphene in the interstellar medium (ISM) is examined by comparing the interstellar extinction curve with the ultraviolet absorption of graphene calculated from its dielectric functions experimentally obtained with the electron energy loss spectroscopy (EELS) method. Based on the absence in the interstellar extinction curve of the $\sim \! 2755\, {\rm \mathring{\rm A} }$ π–π* electronic interband transition of graphene, we place an upper limit of $\sim \! 20\, {\rm ppm}$ of C/H on the interstellar graphene abundance, exceeding the previous estimate by a factor of $\sim \,$3 which made use of the dielectric functions measured with the spectroscopic ellipsometry (SE) method. Compared with the SE method which measures graphene in air (and hence its surface is contaminated) in a limited energy range of $\sim \,$0.7–5 $\, {\rm eV}$, the EELS probes a much wider energy range of $\sim \,$0–50 $\, {\rm eV}$ and is free of contamination. The fact that the EELS dielectric functions are substantially smaller than that of SE naturally explains why a higher upper limit on the graphene abundance is derived with EELS. Inspired by the possible detection of C24, a planar graphene sheet, in several Galactic and extragalactic planetary nebulae, we also examine the possible presence of C24 in the diffuse ISM by comparing the model IR emission of C24 with the observed IR emission of the Galactic cirrus and the diffuse ISM towards l = 44°20′ and b = −0°20′. An upper limit of $\sim \!20\, {\rm ppm}$ on C24 is also derived from the absence of the characteristic vibrational bands of C24 at $\sim \,$6.6, 9.8, and 20 $\, {\rm \mu m}$ in the observed IR emission.