bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive features of ligand‐specific signaling through the estrogen receptor
Authors: Nwachukwu Jerome C , Srinivasan Sathish , Zheng Yangfan , Wang Song , Min Jian , Dong Chune , Liao Zongquan , Nowak Jason , Wright Nicholas J , Houtman René , Carlson Kathryn E , Josan Jatinder S , Elemento Olivier , Katzenellenbogen John A , Zhou Hai‐Bing , Nettles Kendall W
Published: April 2016

Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants of cell‐specific signaling and breast cancer cell proliferation, we synthesized 241 ERα ligands based on 19 chemical scaffolds, and compared ligand response using quantitative bioassays for canonical ERα activities and X‐ray crystallography. Ligands that regulate the dynamics and stability of the coactivator‐binding site in the C‐terminal ligand‐binding domain, called activation function‐2 (AF‐2), showed similar activity profiles in different cell types. Such ligands induced breast cancer cell proliferation in a manner that was predicted by the canonical recruitment of the coactivators NCOA1/2/3 and induction of the GREB1 proliferative gene. For some ligand series, a single inter‐atomic distance in the ligand‐binding domain predicted their proliferative effects. In contrast, the N‐terminal coactivator‐binding site, activation function‐1 (AF‐1), determined cell‐specific signaling induced by ligands that used alternate mechanisms to control cell proliferation. Thus, incorporating systems structural analyses with quantitative chemical biology reveals how ligands can achieve distinct allosteric signaling outcomes through ERα.
Nuclear receptors and AMPK: can exercise mimetics cure diabetes?
Authors: Wall Christopher E , Yu Ruth T , Atkins Anne R , Downes Michael , Evans Ronald M
Published: April 2016

Endurance exercise can lead to systemic improvements in insulin sensitivity and metabolic homeostasis, and is an effective approach to combat metabolic diseases. Pharmacological compounds that recapitulate the beneficial effects of exercise, also known as ‘exercise mimetics’, have the potential to improve disease symptoms of metabolic syndrome. These drugs, which can increase energy expenditure, suppress hepatic gluconeogenesis, and induce insulin sensitization, have accordingly been highly scrutinized for their utility in treating metabolic diseases including diabetes. Nevertheless, the identity of an efficacious exercise mimetic still remains elusive. In this review, we highlight several nuclear receptors and cofactors that are putative molecular targets for exercise mimetics, and review recent studies that provide advancements in our mechanistic understanding of how exercise mimetics exert their beneficial effects. We also discuss evidence from clinical trials using these compounds in human subjects to evaluate their efficacy in treating diabetes.
A g.-1256 A>C in the promoter region of CAPN1 is associated with semen quality traits in Chinese Holstein bulls
Authors: Cui Xiaohui , Sun Yan , Wang Xiuge , Yang Chunhong , Ju Zhihua , Jiang Qiang , Zhang Yan , Huang Jinming , Zhong Jifeng , Yin Miao , Wang Changfa
Published: April 2016

The micromolar calcium-activated neutral protease gene (CAPN1) is a physiological candidate gene for sperm motility. However, the molecular mechanisms involved in regulating the expression of theCAPN1gene in bulls remain unknown. In this study, we investigated the expression pattern ofCAPN1in testis, epididymis, and sperm at the RNA and protein levels by qRT-PCR, western blot, immunohistochemistry, and immunofluorescence assay. Results revealed that the expression of CAPN1 levels was higher in the sperm head compared with that in other tissues. Moreover, we identified a novel single-nucleotide polymorphism (g.-1256 A>C, ss 1917715340) in the noncanonical core promoter of theCAPN1gene between base g.-1306 and g.-1012. Additionally, we observed greater sperm motility in bulls with the genotypeCCthan in those with the genotypeAA(P<0.01), indicating that different genotypes were associated with the bovine semen trait. Furthermore, a higher fluorescence intensity of theCallele than that of theAallele at g. -1256 A>C was revealed by transient transfection in MLTC-1 cells and luciferase report assay. Finally, CAPN1 was highly expressed in the spermatozoa with theCCgenotype compared with that with theAAgenotype by qRT-PCR. This study is the first report on genetic variant g.-1256 A>C in the promoter region ofCAPN1gene association with the semen quality of Chinese Holstein bulls by influencing its expression. g.-1256 A>C can be a functional molecular marker in cattle breeding.
Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice
Authors: Doran Joanne , Walters Cara , Kyle Victoria , Wooding Peter , Hammett-Burke Rebecca , Colledge William Henry
Published: April 2016

TheMfsd14agene, previously calledHiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier protein family. To study the function of the MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) were generated with theMfsd14agene disrupted with aLacZreporter gene. Homozygous mutant mice are viable and healthy, but males are sterile due to a 100-fold reduction in the number of spermatozoa in the vas deferens. Male mice have adequate levels of testosterone and show normal copulatory behaviour. The few spermatozoa that are formed show rounded head defects similar to those found in humans with globozoospermia. Spermatogenesis proceeds normally up to the round spermatid stage, but the subsequent structural changes associated with spermiogenesis are severely disrupted with failure of acrosome formation, sperm head condensation and mitochondrial localization to the mid-piece of the sperm. Staining for β-galactosidase activity as a surrogate forMfsd14aexpression indicates expression in Sertoli cells, suggesting that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis.
A comprehensive transcriptomic view on the role of SMAD4 gene by RNAi-mediated knockdown in porcine follicular granulosa cells
Authors: Zhang Lifan , Du Xing , Wei Shengjuan , Li Dongfeng , Li Qifa
Published: April 2016

As a key mediator of the transforming growth factor-beta (TGF-β) signaling pathway, which plays a pivotal role in regulating mammalian reproductive performance, Sma- and Mad-related protein 4 (SMAD4) is closely associated with the development of ovarian follicular. However, current knowledge of the genome-wide view on the role ofSMAD4gene in mammalian follicular granulosa cells (GCs) is still largely unknown. In the present study, RNA-Seq was performed to investigate the effects ofSMAD4knockdown by RNA interference (SMAD4-siRNA) in porcine follicular GCs. A total of 1025 differentially expressed genes (DEGs), including 530 upregulated genes and 495 downregulated genes, were identified inSMAD4-siRNA treated GCs compared with that treated with NC-siRNA. Furthermore, functional enrichment analysis indicated that upregulated DEGs inSMAD4-siRNA treated cells were mainly enriched in cell-cycle related processes, interferon signaling pathway, and immune system process, while downregulated DEGs inSMAD4-siRNA treated cells were mainly involved in extracellular matrix organization/disassembly, pathogenesis, and cell adhesion. In particular, cell cycle and TGF-β signaling pathway were discovered as the canonical pathways changed underSMAD4-silencing. Taken together, our data revealsSMAD4knockdown alters the expression of numerous genes involved in key biological processes of the development of follicular GCs and provides a novel global clue of the role ofSMAD4gene in porcine follicular GCs, thus improving our understanding of regulatory mechanisms ofSMAD4gene in follicular development.
Posmodernidad. Elementos sociales vinculados con los jóvenes
Authors: Tahull Fort Joan Antonio , Molina Luque Fidel , Montero Iolanda
Published: April 2016

Actualmente estamos instalados en la Posmodernidad. Este periodo se caracteriza por la complejidad, el desorden, las dificultades, las incertidumbres… Estos elementos están incrustados en toda la estructura social y cultural y no pueden reducirse a un ámbito específico. La realidad social no se presenta en compartimentos estancos, sino que todos los sectores están estrechamente relacionados. También los jóvenes reciben una influencia importante del entorno, y es este hecho en particular el que aborda este artículo, en orden a evidenciar el contexto y lo periférico que determina la identidad de los jóvenes. Sin presentarlo de forma directa, nos iremos acercando progresivamente al objeto de estudio, en relación con el cual se precisan algunos acontecimientos históricos relevantes y los elementos teóricos necesarios para comprender las transformaciones acaecidas. Esta información aparentemente tangencial se hace imprescindible para entender los procesos sociales seguidos de los últimos años.
Formación, cultura e imagen
Authors: Parra Rozo Omar Antonio , Díaz Pérez Vianney Rocío , Barrios Tao Hernando
Published: April 2016

El contexto de enseñanza y aprendizaje supone abordar los temas que brinda el medio y llevan a que el profesor se sitúe en un plano desde el cual pueda entender el discurso del estudiante y generar nuevas didácticas para la formación de un pensamiento crítico. Atreverse a utilizar un lenguaje paralelo a la palabra, como la imagen, exige una planeación y una inserción en un referente que luego será analizado, criticado y aceptado o rechazado por el estudiante. Este artículo se ubica en el ámbito del método hermenéutico analógico, en tanto acude a una revisión literaria y a una interpretación del concepto de cultura y de mediación práctica desde las formas de expresión narrativa dadas por la imagen, en particular el cine, y asume el sendero de la interpretación y de la contemplación hermenéutica de autores representativos para brindar un mensaje polisémico y un marco referencial con posibles aplicaciones prácticas en la formación de un sujeto hiperactivo e interactivo.
Humanismo e formação (Bildung) em tempos de TICs: aproximações hermenêuticas
Authors: Schuck Rogério José
Published: April 2016

Os últimos 20 anos foram de enormes mudanças para a humanidade, impulsionadas sobretudo pelas Tecnologias da Informação e Comunicação –TICs–, afetando a vida em todas as dimensões. O texto busca investigar a questão do humanismo nesse contexto, discutindo a relação tempo e espaço para compreender como as TICs têm sido centrais na mudança de postura e de construção do conhecimento. Seguindo a perspectiva da hermenêutica filosófica, de modo especial nas trilhas abertas por Hans-Georg Gadamer, o conceito apropriação da tradição e aproximações com o conceito formação (Bildung) abrem perspectivas para a discussão pelas vias da hermenêutica filosófica. De que modo está se dando a formação (humanística, intelectual, social) dentro desse contexto? Qual o espaço possível ao humanismo diante de um cenário extremamente complexo e plural, permeado pelas TICs? Em que sentido as TICs contribuem ou não para (re)pensarmos a questão da postura humana frente ao saber? São questões deveras complexas e que exigem mediações (que nos deem) (na busca por) algumas pistas em pro de respostas, mesmo que ainda abertas.
Cristo desnudo en la cruz: el problemático comienzo de dicha representación
Authors: Osorio Arango John Jairo
Published: April 2016

Para nada fácil que las primeras comunidades cristianas llegaran con resolución a la representación del patíbulo en el cual fuera (aparentemente) derrotado el Hijo de Dios. El tema de la ejecución (condenación y maldición) sumado al problema plástico (proclive a la idolatría), parecen explicar la tardanza de llegar a ese primer intento de un crucificado que encontraremos solo hasta el siglo IV-V. Poco después se da la respuesta teológica que pretendía superar la problemática herejía que negaba o separaba la condición divina de la humana y otro tanto después el papel devocional, espiritual y (si se lo quiere) litúrgico de dichas representaciones. Pero mucho antes del Renacimiento Humanista del siglo XV ya el franciscanismo del siglo XIII habría hecho de esta temática, con un particular velo de pureza, una feliz y primera gramática del todo significativa y tanto más única para la revelación así como para esta estética.
Bajo el crepúsculo de la debilidad. Reseña de L’Éducaction Sentimentale, de Gustave Flaubert
Authors: Moreno Perdomo Felipe
Published: April 2016

En noviembre 1869 aparece en París; bajo la edición de Michel Lévy frères, L’Éducation Sentimentale, de Gustave Flaubert. La lectura general del libro discu- rre frente los espejos sociales y de las reiteradas críticas literarias que terminan por angustiar al autor Ruanés. Años atrás él había afirmado en su correspon- dencia que su redacción representaba uno de los momentos más álgidos de su creación literaria y que se esforzaba por realizar una obra completa. Para Yvan Leclerc, especialista de Flaubert en la Université de Rouen, la redacción ejercida por Flaubert responde al esfuerzo más allá de lo humano, entendiendo esto no como una dificultad sino como un compromiso literario que se hace evidente en cada párrafo o idea. Existe, según Leclerc, detrás del discurso literario un trabajo muy profundo sobre lo verbal, la palabra, el sujeto, el adverbio, el sustantivo y por ende la idea general. Podríamos imaginar aquellas jornadas exigentes de trabajo –normalmente entre 10 y 12 horas de lectura y escritura en su casa de Croisset– que Flaubert dedicaba a elaborar diversos textos: una novela, uno de sus cuentos atemporales e introspectivos o una de todas las cartas que conforman su extensa correspondencia. Asímismo podríamos intuir todo el universo que podría convergir en la mente de uno de los mejores escritores del siglo XIX en Francia. Universo que se componía sobre todo de una formación en derecho, en letras y, no menos importante, en medicina.
The art of the old masters — Tableware of the Anabaptists and Haban faience from Western Slovakia in the collections of the Austrian Museum of Folk Life and Folk Art in Vienna
Authors: Peschel-Wacha Claudia
Published: April 2016

The Austrian Museum of Folk Life and Folk Art in Vienna was founded in 1895. From the beginning, ceramics were collected. Today, the ceramic collections include about 15,000 objects, of which more than 300 are faiences most probably originating from the west of Slovakia. About 70 of these are from the 17th century and about 80 from the 18th century. Many of the objects entered the collections in the early years of the museum through donations and purchases. An important patron was the art historian Alfred Ritter Walcher von Molthein (1867–1928). He was one of the 19th century researchers and collectors who started the Haban myth about the Hutterites.

Between 1974 and 2008, the Austrian Museum of Folk Life and Folk Art had a branch museum in Burgenland, the Ethnographic Museum in Kittsee Castle. During restoration work on the castle, shards were found that are known as the Kittseer Kellerfund (Kittsee cellar find)
Archaeological excavation of the Haban colony site at Sárospatak
Authors: Ringer István
Published: April 2016

This article reports on the first results of the archaeological excavation of the Haban colony site in Sárospatak begun in 2010. It describes the circumstances of the origin of the Anabaptist colony that can be located precisely from topographical data, and briefly outlines the history of the Haban colony in Sárospatak. In the first two years of the exploration on the basis of a research programme, the archaeological exploration of the house at No. 8 Kövi Sándor utca began; the main aim was to clarify the stratigraphy of the place with test trenches. In the course of the work an unexpected quantity of archaeological finds that can be linked to Anabaptist ceramics came to light. Especially important are the finds that can be linked to the firing kiln: the bricks of the kiln, the firing slabs, saggars, fragments of the crucibles used to melt the glazes. The lead-glazed ceramics of the Anabaptists are little known in research on Early Modern ceramics. The lead-glazed ceramics unearthed from the site of the Sárospatak colony differ strikingly from Early Modern pottery of the region. It will be the task of further research to decide whether the Habans produced lead-glazed ceramics exclusively for their own needs or also for the market.
Newly discovered Anabaptist settlement at Čermákovice (Alinkov farmstead, municipality of Horní Kounice, Znojmo district)
Authors: Pajer Jiří
Published: April 2016

Anabaptist settlements formed a specific enclave in the area of western Moravia, named “Horní dvory” in chronicles. They include Trstěnice (Stiegnitz), Tavíkovice (Teikovitz), Višňové (Wischenau), Skalice (Skalitz) and Čermákovice (Schermankowitz). According to written reports and archaeological finds, a settlement at Čermákovice, situated on the territory of the municipality of Horní Kounice, was in 2014 identified with Alinkov farmstead. The closed rectangular courtyard forms a unique preserved complex, comprising a main residential building, an adjacent residential building with a mill, and a row of farm buildings. In the main residential building, interior spaces were identified which served the needs of the Anabaptist community at Čermákovice as a whole.
Examination of Haban vessels with uranium-bearing blue glaze
Authors: Ridovics Anna , May Zoltán , Bajnóczi Bernadett , Tóth Mária
Published: April 2016

From the mid-15th century “berettino”, or “turchino”, lighter and darker, deep blue, cobalt-bearing glazes were used on Italian maiolica objects. At first such vessels were made mainly in Faenza, later they spread to Northern Italy and from the 17th century they became popular throughout Europe. According to written sources and archaeological finds, potters working in the Anabaptist-Hutterite settlements used blue glaze right from the start. From the second half of the 17th century there was an increase in the quantity of light and dark blue vessels that were made in many places. In the course of archaeometric research using a handheld X-ray fluorescence spectrometer (XRF), more than 500 Hutterite and Haban objects were analysed; of these circa 140 had a blue glaze. The measurements made on blue glazes and decorations found uranium in addition to cobalt in 107 objects. Some of the 17th century vessels and stove tiles were made in Alvinc (Vinţu de Jos, Romania), Sárospatak, and probably in Szobotist (Sobotište, Slovakia). The vessels with a blue or a white glaze, generally painted roughly with a brush, form a characteristic group provisionally attributed to a “mining town workshop”. Their production began at the end of the 17th century and was passed on by tradition until the 1780s. The workshop probably operated in the vicinity of a mining town in the former Zólyom county, along the upper reaches of the Garam river, in the vicinity of Besztercebánya (Banská Bystrica, Slovakia).
The tin content of the blue-glazed Hutterite and haban ceramics — Implications for the production technology based on results of the handheld XRF and electron microprobe analyses
Authors: Bajnóczi Bernadett , May Zoltán , Ridovics Anna , Szabó Máté , Nagy Géza , Tóth Mária
Published: April 2016

The Hutterites and Habans produced coloured-glazed, mostly blue- and yellow-coloured vessels alongside their white-glazed faience ware. However, the production technology of the coloured-glazed vessels, specifically the nature of the glaze, is a matter of debate among scholars. Both coloured tin glaze and coloured engobe covered with a transparent lead glaze were thought to have been applied on the ceramics.

Around 140 objects of blue-glazed Hutterite and Haban museum objects and archaeological artefacts were analysed using a handheld XRF spectrometer. In addition, small fragments of selected ceramics were studied by electron microprobe analysis (EMPA).

According to the XRF measurements the blue glaze of all except one of the studied Hutterite and Haban ceramics contains tin in variable amounts (from about 0.015 wt% up to 13 wt%). The EMPA technique showed that tin in the form of tin oxide opacifier was deliberately added to the single-layered alkali– lead or lead–alkali glaze. These data confirm that the tin glaze technique was used during production of blue-glazed ceramics, and in this respect they can be regarded as faience. The blue glaze of the Haban vessels produced by a “mining town” workshop contains tin in very low concentrations (Sn <0.2 wt% by XRF), therefore the opacity of the glaze is mainly caused by the abundant silica and arsenate particles.
Brief collection history of the Haban ceramics in the museum of applied arts in the light of Haban research
Authors: Balla Gabriella
Published: April 2016

The Museum of Applied Arts has the richest collection of Haban ceramics of any public collection in Hungary. The museum preserves close to four hundred items of Haban ceramics made before 1760: vessels, stove tiles, a stove and floor tiles. The article presents the history of the collection with special regard to the aims of the collecting, the circumstances of acquisitions and the most important collectors. It cites the thought of Jenő Radisics, the director general who has made the greatest contribution to the museum, on collection building that can be regarded as the most up-to-date museum conception at the turn of the 19th to the 20th century, particularly because his ideas laid the foundations for the 21st century philosophy of museums. These Haban ceramics intended for the use of aristocrats also served as a material relic of the national consciousness of European nation-states.
The Museum of Ethnography’s Haban ceramics in Budapest
Authors: Vida Gabriella
Published: April 2016

The Ceramics Collection in the Museum of Ethnography contains around 2300 faience objects, of which 60 are classical Haban vessels and at least 1500 are Late Haban pieces. There are examples of transition between Haban style periods and exceptions that make this collection unique, compared to other collections of Haban objects. The largest collection in Hungary of Late Haban objects is also found here. The study presents the most interesting pieces, how the larger groups entered the collection, and the different object groups. It describes 45 archaeological finds unearthed on the sites of three Haban settlements, that provide valuable information on the technique used to make them. Based on the ornamentations on a Haban product from 1732 we can date and identify two types from Nagylévárd (now Veľké Leváre, Slovakia): one with coloured painting and the other one with blue ornamentation on a white ground). The study calls for a debate on ceramics history to clarify questions related to both Haban and lead-glazed pottery produced in a micro-region by the German-speaking people living in the mining towns in the first half of the 18th century. Late Haban ware was popular throughout the entire territory of Hungary in the 18th to 19th centuries. Examples have been found in almost all micro-regions.
Haban ceramics in the collections of the Savaria Museum
Authors: Dabóczi Dénes
Published: April 2016

The settlement and activity in Western Transdanubia of Anabaptists was first studied by Béla Iványi, law and cultural historian, then by Imre Katona, art historian. Building on the data they found in archives, this article presents the activity of the Habans in Vas County in the 16th to 17th centuries. A few details from inventories show what a rich store of their ceramics was to be found in aristocratic and noble castles and well-to-do town houses in the county. There is no longer any trace of that material. In all there are 17 pieces of Haban ceramics in the collections of Vas County museums. The 12 objects with dates and guild symbols presented here were made between 1676 and 1754. Presumably they are not the work of local Haban potters because their communities in Vas County ceased to exist after 1662. Only two objects have a reliably known provenance (Fig. 8 and 9); they can be attributed to the Odler workshop in Dejthe (Dechtice, Slovakia).
Haban pottery in Transylvania
Authors: Roşca Karla
Published: April 2016

Product of a craft with mediaeval roots in Western and Central Europe, Haban pottery represents an exceptional field in the art of clay modelling. The article presents a short history of Hutterite settlement in Transylvania, the manufacturing technology used for the pottery ware and the wonderful pieces of Haban pottery from the collection of the Emil Sigerus Museum of Saxon Ethnography, some of them belonging to the first period of Haban pottery from Alvinc (Vinţu de Jos, Romania) 1671, but also examples of post-Haban ware from the 18th century.
Javaslat a terhesgondozás és perinatológiai ellátás egységes minőségkontrollját célzó, Europeristat-konform adatszolgáltatási rendszer bevezetésére Magyarországon
Authors: Berkő Péter
Published: April 2016

It is a regrettable deficiency in the Hungarian healthcare that the culture and the system of quality control of cure have not been formed (except for a few subspecialties, units or wards). If hospital wards do not have a national, professionally unified and modern information system presenting the most important quantity and quality indicators of their medicinal activity annually, a stable basis for definition of future tasks is absent. The author puts forward a proposal for the establishment of the information systems for different professional fields. On the basis of experience of perinatological information system operating for over 3 decades in Borsod-Abaúj-Zemplén county, he also proposes introduction of a nationally unified, Europeristat-compatible information system following Tauffer-statistics which may serve as a uniform quality control of obstetrics and perinatological care, as well as introduction of its base, the dataform “TePERA” (Form of Obstetrics and Perinatological Care Risk). Orv. Hetil., 2016, 157(18), 687–694.
A rövid hatású, szájon át adható morfinszármazékok hazai elérhetőségének elemzése
Authors: Lovas Kornélia , Hadnagy László , Jobban Eszter , Kullmann Tamás
Published: April 2016

Short acting oral formulas make part of optimal opioid analgesia. The use of short acting oral morphine has not widely spread in Hungary, and these drugs completely lacked from the market for three years. Since December 2015 short acting morphine-sulphate has again been commercialised. The causes of the market failure are analysed in this article. The aim of the retrospective analysis is to help the accessibility of the medicine to every patient in need. Prescription morphine use depends on the harmonised cooperation of a number of actors. Besides regulating and financing authorities and professional organisations, patients and the opinion forming media are also responsible for building up the right routine. Orv. Hetil., 2016, 157(18), 695–699.
Betegjogok etnikai metszetben
Authors: Lukács Ágnes , Feith Helga Judit
Published: April 2016

Introduction: The perception of health and sickness are culturally determined and, therefore, ethnic and religious socialization forms attitudes toward the medical system. During everyday practice, patients’ rights and obligations, which are based on the norms of the major society, confront Roma minority norms. Aim: The aim of the authors was to explore the main interferences of patients’ rights and obligations during the medical care of the Roma. Method: The authors analyzed the results of medical anthropology, health sociology, and the experience obtained from more than 40 courses about patients’ rights. Results: Cultural determinants, effects of the lower socioeconomic status and social-psychological mechanism equally form the situations of healthcare and the observance of patients’ rights and obligations. Conclusions: Most of the misunderstandings between healthcare workers and Roma patients stem from the lack of knowledge about cultural differences. Therefore, transcultural approach and Romani studies should be significant part of graduate and postgraduate courses in the field of medical education. Orv. Hetil., 2016, 157(18), 712–717.
Az adalimumab hatékonysága és biztonságossága hagyományos kezelésre refrakter colitis ulcerosában
Authors: Rutka Mariann , Bálint Anita , Farkas Klaudia , Palatka Károly , Lakner Lilla , Miheller Pál , Rácz István , Hegede Gábor , Vincze Áron , Horváth Gábor , Szabó Andrea , Nagy Ferenc , Szepes Zoltán , Gábor Zoltán , Zsigmond Ferenc , Zsóri Ágnes , Juhász Márk , Csontos Ágnes , Szűcs Mónika , Bor Renáta , Milassin Ágnes , Molnár Tamás
Published: April 2016

Introduction: Adalimumab was approved for the treatment of ulcerative colitis refractory to conventional therapy several years later than infliximab in Europe. Due to the relatively low remission rate observed in Ultra trials, data on the efficacy of adalimumab in ulcerative colitis are really helpful in the daily practice. Aim: The aim of this study was to prospectively collect data on induction and maintenance adalimumab therapy in patients with ulcerative colitis treated in Hungarian centres. Method: This prospective study collected data of all patients with ulcerative colitis treated with adalimumab in 10 Hungarian centres. The primary endpoints of the study were rates of remission, response and primary failure at week 12, and the rate of continuous clinical response, remission and loss of response at weeks 30, and 52. Secondary endpoints were endoscopic outcome at week 52 and comparison of the efficacy of adalimumab between treatment naive and infliximab-experienced patients. Results: 73 patients with active ulcerative colitis were enrolled in the study. 75.3% of the patients exhibited clinical response after the induction at week 12. The probability of maintaining adalimumab treatment was 48.6% at week 52 with a continuous clinical response in 92% of these patients. Mucosal healing was achieved in 48.1% of the patients at week 52. Dose intensification was performed in 17.6% of the patients. Minor side effects developed in 4% of the patients and 5.4% of the patients underwent colectomy during the 1-year treatment period. Conclusions: These results coming from the real clinical setting demonstrate a favourable efficacy of adalimumab induction and maintenance therapy in patients with ulcerative colitis. Orv. Hetil., 2016, 157(18), 706–711.
Háromdimenziós, gyors, kétfoton-pásztázó eljárások sejt- és hálózatszintű idegsejtvizsgálatokhoz
Authors: Szalay Gergely , Judák Linda , Szadai Zoltán , Chiovini Balázs , Mezey Dávid , Pálfi Dénes , Madarász Miklós , Ócsai Katalin , Csikor Ferenc , Veress Máté , Maák Pál , Katona Gergely
Published: April 2016

Erratum to the article published on December 27th 2015 in Issue 52 of Orvosi Hetilap [Orv. Hetil., 2015, 156(52), 2120–2126, DOI: 10.1556/650.2015.30329]. The name of Dávid Mezey was not correctly typed. The corresponding author asked for the following correction to be published.
On purposefulness of application of physical culture-health related technology for prophylaxis of students’ respiratory system disorders
Authors: Kondakov V.L. , Kopeikina E.N. , Usatov A.N.
Published: April 2016

Purpose: To give scientific foundation and experimental proof of physical culture-health related technology for prophylaxis of respiratory system disorders. Material: in the research students: girls (n= 43) and boys (n=40) participated. In process of academic physical culture classes students practices: dozed health walks )as warming up), respiratory exercises by methodic of A.N. Strelnikova and G. Childers (which were used as main corrective mean of respiratory system’s functional state), health swimming (for motor functioning intensification) outdoor games (as mean of active leisure). Results: The conducted research witness about general positive influence of the worked out technology of disorders’ prophylaxis on students’ somatic health. The technology was constructed on the base of synthesis of the most effective means of health related physical culture. In its basis we put generalized data about their impact. Main characteristic of this technology is its orientation on definite health improvement tasks in compliance with peculiarities of trainees’ contingent. The technology permits to present its content and orientation as integral mean of strengthening of organism’s functional potentials as well as ensuring of high effectiveness of students’ educational process. It permits to significantly reduce impacts of respiratory system’s disorders. Conclusions: The worked out technology permits to present its content and orientation as integral mean of strengthening of organism’s functional potentials.
Study of personality’s temperament and self-assessment of higher educational establishments’ students
Authors: Liashenko V.N. , Tumanova V.N. , Hatsko E. V.
Published: April 2016

Purpose: analysis of temperament and self-assessment characteristics in higher educational establishment students. Material: in the research 1st and 2nd year students (n=30) participated. Questioning was used, with the help of which personality’s self assessment and temperament characteristics were estimated. Results: the study of students’ temperament structure showed low demand in mastering of objective world and strive for mental and physical labor. High indicator of social activity and interpersonal skills was registered. The following indicators of self-assessment were received: 15% of students had too low self-assessment, 50% of students have adequate self-assessment and 10% have excessively high self-assessment. Conclusions: quickness of psychic processes (tem and rhythm), impressiveness and emotional sensitivity are important features of temperament. Students demonstrated feeling of anxiety and worry in respect to their studying at university. Besides the have sensitivity to failures to non coincidence of the desired and the results. студентов. With it students have adequate self assessment.
Factorial structure of physical rehabilitation group students’ complex fitness
Authors: Sobko I.N. , Ulaeva L.A. , Yakovenko Y.A.
Published: April 2016

Purpose: differentiation of physical education process on the base of morphological-functional state and physical fitness indicators, psycho-physiological potentials of physical rehabilitation group’s students. Material: 50 1st year students of 17-18 years’ age participated in the research. Tests for assessment of students’ morphological-functional state were used. Psycho-physiological testing was carried out with the help of computer program. Results: we marked out 5 factors, which characterize main components of students’ physical condition. It was determined that low level of students’ physical and functional potentials weakens functioning of organism’s most important functions. It was found that the most important factors in complex fitness of physical rehabilitation group’s students are power and functional potentials. Conclusions: it is necessary to purposefully work on formation of students’ comprehensive motor potential. Results of the research permit to rationally distribute physical education means and methods in practical trainings of physical rehabilitation group.
PHYSICAL AND HEALTH EDUCATION FACING THE TECHNOLOGY CHALLENGE
Authors: Pop Cristiana Lucretia
Published: April 2016

Purpose: This essay aims to signal up the detrimental effects of sedentary behaviours determined by extensive use of technology. Material: The paper is a survey of the most relevant data related to physical inactivity consequences with a specific reference to the Eastern Europe countries. Results. There is no doubt that children and young people will prefer the technology and its commodities, but they need to be encouraged to practice exercise, to control their posture and weight. Physical activity favorably influences on mental health and reduces the incidence and severity of diseases and pathological conditions, such as cardiovascular disease, type II diabetes, osteoarthritis, osteoporosis and obesity. Conclusions. Promoting physical activity as a healthy life style component in schools and in universities targets the enhancement of vigour, resilience, employement and social outcomes for graduates and comunities.
SUPERSTITIOUS BEHAVIOR AMONG JUDO, TAEKWONDO AND BOXING PLAYERS
Authors: Gaurav Dureja , Gagandeep Singh
Published: April 2016

Purpose: The present study was designed to measure superstitious behavior among Judo, Taekwondo and Boxing players. Material: Thirty (N=30) male inter-college level players with the age group of 19-25 years were selected through purposive sampling technique to act as subjects from affiliated colleges of Panjab University, Chandigarh. They were further divided into three groups: Group-A [Judo (n=10)], Group-B [Taekwondo (n=10)] and Group-C [Boxing (n=10)]. One Way Analysis of Variance (ANOVA) was applied to find out the differences among judo, taekwondo and boxing players. Where F values found significant, Least Significant Differences (LSD) Post-hoc test was applied to find out the direction and degree of difference. Results: The level of significance was set at 0.05. The result revealed significant differences among judo, taekwondo and boxing players on the sub parameters: clothing and appearance, preparation, team ritual and coach. However, no significant differences have been observed on the sub-parameters fetish, game/competition, prayer and parameter superstitious (Total). Conclusions: The obtained results showed significant differences on the sub-parameter Coach among Judo, Taekwondo and Boxing players. While calculating the mean values of entire groups, it has been observed that Boxing players demonstrate significantly better on the sub-parameter Coach. Therefore, it can be ascertained that Boxing players are more confident that coach bring a lucky charm to our game.
Evaluating the Utility of Baseline Cardiac Function Screening in Early-Stage Breast Cancer Treatment
Authors: Truong Sandy R. , Barry William T. , Moslehi Javid J. , Baker Emily L. , Mayer Erica L. , Partridge Ann H.
Published: April 2016

Background.

Cardiotoxicity can be a complication of anthracycline- or trastuzumab-based therapy for breast cancer patients. Screening echocardiograms (ECHOs) and radionuclide ventriculograms (RVGs) are often performed before administration of these agents to evaluate cardiac function. Limited evidence for the clinical utility of these screening tests is available.

Methods.

Early-stage breast cancer patients diagnosed from 2006 to 2011 (n = 1,067) with baseline ECHOs/RVGs were identified in a single institution prospective registry. Medical record review was performed to obtain pre- and post-ECHO/RVG treatment plans, baseline ECHO/RVG results, cardiac risk factors, and cardiac events. Patients with cardiac history were excluded. ECHO/RVG abnormalities were defined as ejection fraction (EF) <55%, valvular disease, left ventricular hypertrophy, and diastolic dysfunction. Cardiac events were defined as heart failure, myocardial infarction, arrhythmia, valvular disease, or angina during or after chemotherapy.

Results.

Among 600 eligible patients, abnormal ECHO/RVG results were observed in 13 (2.2%, 1.2%–3.7%), including 9 with baseline EF <55%. There were no detected changes in treatment plans, although more frequent cardiac monitoring was recommended for 2 patients. There were no significant differences in age, race, menopausal status, smoking history, alcohol use, body mass index, or medical comorbidities between patients with abnormal and normal results. In follow-up (mean, 4.0 years; range, 0–8.3), 15 patients developed cardiac events (none of whom had had abnormal baseline ECHOs/RVGs).

Conclusion.

Baseline ECHO/RVG in patients without prior cardiac history rarely yields an abnormality that prompts change in planned anthracycline- and/or trastuzumab-based treatment. Moreover, few cardiac events developed in this screened population in follow-up.
Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors
Authors: Molina-Cerrillo Javier , Alonso-Gordoa Teresa , Martínez-Sáez Olga , Grande Enrique
Published: April 2016

The carcinoid syndrome represents a set of signs and symptoms associated with neuroendocrine tumors (NETs) that occur primarily when metastases are developed in the liver, resulting in the worsening of quality of life. Serotonin plays a central role in the physiology of carcinoid syndrome by promoting intestinal motility. Somatostatin analogs (SSAs) have widely demonstrated their efficacy as symptomatic relievers of carcinoid syndrome, but this control is ephemeral, being reduced by approximately 50% within the first year. The exact mechanisms of resistance to SSAs are not fully understood, but it is believed that serotonin might be involved. Patients with carcinoid syndrome present with a significant increase in serotonin plasma levels and, consequently, in the soluble urinary metabolite 5-hydroxyindole acetic acid. Telotristat etiprate is a potent inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the synthesis of serotonin, that has demonstrated in the phase III TELESTAR clinical trial a significant improvement in the control of bowel movements in patients with NETs who have carcinoid syndrome and who have progressed to an SSA. Based on these results, telotristat etiprate has emerged as a potential new option in the treatment algorithm of symptomatic control of functioning NETs. However, some issues need to be clarified, such as the safety profile of the drug outside clinical trials, the benefit in quality of life, and the possible impact on tumor growth, as well as its role within sequencing or combination treatment strategies with pre-existing drugs effective in NET treatment.
Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer
Authors: O’Sullivan Ciara C. , Bates Susan E.
Published: April 2016

In this issue of The Oncologist, Agarwal et al. report negative results from a phase I trial of LFA102. Although “negative” in terms of antitumor activity, the study provides useful pharmacokinetic and pharmacodynamic information. Future trials evaluating PRLR blockers alone and in combination with other agents may still be warranted in patients with breast and prostate cancer.
Identifying bumble bees across India.
Authors: Engel Michael S.
Published: April 2016

Book review of: Saini, M.S., R.H. Raina, & H.S. Ghator. 2015. Indian Bumblebees. M/s Bishen Singh Mahendra Pal Singh; Dehra Dun, India; [v]+248 pp.  ISBN 978-81-211-0827-0 [hardback].
A new species of Systropha from Thailand (Hymenoptera: Halictidae: Rophitinae)
Authors: De Silva Nicholai , Packer Laurence
Published: April 2016

Systropha sirikitae de Silva & Packer, new species, from Thailand is described and illustrated.  It is known only from the male.  Patiny & Michez’s (2006) key to males of Systropha is modified to permit its identification.  It would seem to be the second known species of the subgenus Systrophidia Cockerell.
Las relaciones civiles-militares en las transiciones soviética y española. Similitudes y disimilitudes
Authors: Roblizo Colmenero Manuel
Published: April 2016

Siendo generalmente los Ejércitos, tanto en la retótica del régimen como en la realidad, la columna vertebral sobre la que se ha asentado el sistema no democrático en cuestión, su aceptación de los cambios resulta un elemento esencial, por una razón que no escapa a nadie: la posesión de la fuerza. Aun cuando no posea la legitimidad del Estado para su empleo, que en todo caso está en los responsables políticos del país, el Ejército es el único elemento de la sociedad que está en condiciones de imponer violentamente sus criterios.
The Performer as Philosopher and Diplomat of Dissensus: Thinking and Drinking Tea with Benjamin Verdonck in Bara/ke (2000)
Authors: Stalpaert Christel
Published: April 2016

Ecology and activism is a burning issue in theatre and performance studies. However, following the French philosopher Bruno Latour, a radically new encounter with ecology is needed today, if eco-activism still wants to have a future. It seems that, in order to survive, eco-activism and eco-art have to move beyond their narrow and limited anthropocentric perspective. In this paradigm shift, the performer as philosopher – in the sense of a diplomat of dissensus – might play an important role. The Flemish artist and performer Benjamin Verdonck picks up this role of a performer as philosopher. In his artistic tree houses, Verdonck invites passers-by for coffee or tea and gently raises ecological issues. He performs protest as what I call “a diplomat of dissensus”, combining Latour’s writings on contemporary ecology and the function of the diplomat therein, and Jacques Rancière’s writings on dissensus and art in public space. Ecology, for its part, moves into the direction of what Félix Guattari in The Three Ecologies refers to as “the ethico-aesthetic aegis of an ecosophy” (Guattari 2000, 41), a contraction of ecology and philosophy that connects the environmental with a reflection on the psychic production of subjectivity and social relations.
Encountering Worlds: Performing In/As Philosophy in the Ecological Age
Authors: Florêncio João
Published: April 2016

Within the context of the ‘Anthropocene’, the current geological epoch marked by the impact of human activity on terrestrial ecosystems and geological formations, this article considers the ways in which the ecological blurring of boundaries between ‘Nature’ and ‘Culture’ might affect existing ontologies of performance. Departing from Richard Bauman’s definition of performance as both communication and enactment, we will use the postulates of Graham Harman’s Object-Oriented Ontology to speculate on what performance might mean beyond the human/nonhuman divide.  Ultimately, it will be claimed, performance, understood as both enactment and unveiling, is at the core of all encounters between all bodies and irrespective of their perceived nature. As a result, the world must once again be thought as theatrum mundi, as a stage where bodies always encounter one another through the contingency of the personae they play, personae that nonetheless are unable to exhaust the full being of the bodies behind them.
The Processes of Eavesdropping: Where Tragedy, Comedy and Philosophy Converge
Authors: Rokem Freddie
Published: April 2016

Eavesdropping scenes, where one of the characters eavesdrops or spies on one or several of the other characters (usually with the knowledge of at least one of them) will serve as my point of departure for exploring the relations between tragedy, comedy and philosophy. The eavesdropper is a spectator inside the fictional world who because of what he (and most frequently it is a male) learns by eavesdropping or just by carrying out this act of transgression is transformed into a victim. I exemplify with Polonius (in Hamlet, III, 4) and Orgon (in Tartuffe, IV, 5), who are physically situated in a focal (liminal) point where the eavesdroppers become vulnerable and can quickly be transformed from tragic to comic figures and vice versa, transgressing the generic borderlines between tragedy, melodrama, comedy and farce. There are also many instances where philosophical discourses originate from an eavesdropping situation, the most obvious being the form of teaching practiced by Pythagoras, lecturing to his students from behind a curtain. My article also examines examples of eavesdropping in the writings of Plato and Walter Benjamin.