bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Antracnosis with Electrochemically Activated Salt Solutions (EASSs) on Bean Culture
Authors: Marquez-Blanco María Guadalupe , Meas-Vong Yunny , Guerrero-Aguilar Brenda Z. , Rivero-Montejo Samantha de J. , Contreras-Medina Luis Miguel , Torres-Pacheco Irineo , Guevara-González Ramón Gerardo , González-Chavira Mario Martin , Ortega-Torres Adrian Esteban
Published: July 2023

Common bean (Phaseolus vulgaris L.) is an important crop for food security and for national economics for several countries worldwide. One of the most important factors of risk in common bean production is the fungal disease anthracnose caused by Colletotrichum lindemuthianum, which, in some cases, causes complete yield losses; this kind of plant disease is usually managed through the application of chemical products such as fungicides that are commonly not accepted by society. This rejection is based on the relationship of pesticides with health damage and environmental contamination. In order to help in solving these drawbacks, the present work proposes the use of electrochemically activated salt solutions (EASSs) as a safer pathogen control agent in crops, due to it having shown an elicitor and biostimulant effect on plants. With this background, this manuscript presents in vitro results of the evaluation of the inhibitory effect for multiple bean pathogens and in vivo results of EASS in the common bean–Colletotrichum pathosystem by evaluation of the infection severity and defense activation, such as secondary metabolite production and antioxidant activity. EASS presence in growth media had a strong inhibitory effect at the beginning of experiments for some of the evaluated fungi. EASSs showed an effect against the development of the disease when applied in specific doses to prevent distress in plants.
Somatic Growth and Maturity for Four Species of River Cooter Including Pseudemys concinna suwanniensis, P. nelsoni, P. peninsularis, and P. texana
Authors: Siders Zachary A. , Stratmann Theresa A. , Turner Tomaszewicz Calandra N. , Walde Andrew S. , Munscher Eric C.
Published: July 2023

Pseudemys is a genus of commonly occurring freshwater turtles with limited growth information across their long lifespans. We used 11,361 mark-recapture events to estimate the somatic growth rates of P. nelsoni, P. peninsularis, P. concinna suwanniensis, and P. texana from freshwater springs and developed a Bayesian growth model to estimate the species-specific, site-specific, and individual effects on growth. We corroborated evidence for fast juvenile growth and slower adult growth in Pseudemys but found uncommonly fast growth rates, with turtles doubling or tripling in size in the first year. P. texana males had the smallest average maximum size (L∞, 243 mm), while P. c. suwanniensis females had the largest (423 mm). Environmental conditions at springs had significant effects on k, the growth coefficient, but not L∞. We derived, using a ratio of length at maturity to L∞ (71.7% and 87%, males and females), that females matured 1.15–1.57 times older than males except for P. c. suwanniensis, which matured three times older. Given the local abundance declines in many Pseudemys from anthropogenic impacts, this study provides important baseline life history information for Pseudemys species for use in ongoing conservation efforts and presents a novel hierarchical modeling approach using a long-term mark-recapture dataset.
Blood Profiling of Athletes after COVID-19: Differences in Blood Profiles of Post-COVID-19 Athletes Compared to Uninfected Athletic Individuals—An Exploratory Analysis
Authors: Vollrath Shirin , Matits Lynn , Jerg Achim , Zorn Jule , John Lucas , Steinacker Jürgen Michael , Bizjak Daniel Alexander
Published: July 2023

Blood profiling data in athletic populations and their respective responses to SARS-CoV-2 infection are lacking. Thus, this exploratory pilot study aimed to analyze and compare clinical blood markers in previously infected trained athletes (ATH; 30 m/29 f) and a not previously infected healthy athletic control group (HC; 12 m/19 f). The ATH group undertook a sports medical examination which included extended blood analyses. Blood profiles with a total of 74 variables were assessed (blood counts, pro-/inflammatory and immunological markers, and micronutrients), and the ATH group was compared to the age-matched, vaccinated HC group with comparable athletic back grounds, though without previous SARS-CoV-2-infections. The ATH group showed lower IgG, Troponin-T levels, and they had a lower complement/acute-phase protein activation. Furthermore, Vitamin D levels were lower and electrolyte/micronutrient concentrations were higher in ATH. Soluble transferrin receptor as a marker of erythrocyte turnover was decreased whereas PTT as a coagulation marker was increased. Subgroup analyses according to sex revealed more differences between the women of the ATH and HC groups (for 25 different variables) than between the men (for 5 different variables), especially for immunological and metabolic variables. In particular, the immune system and electrolyte/micronutrient status should be observed frequently and sex-specifically in this athletic cohort.
Comparison of Prostate-Specific Antigen and Its Density and Prostate Health Index and Its Density for Detection of Prostate Cancer
Authors: Boo Youngjun , Chung Jae Hoon , Kang Minyong , Sung Hyun Hwan , Jeon Hwang Gyun , Jeong Byong Chang , Seo Seong Il , Jeon Seong Soo , Lee Hyun Moo , Song Wan
Published: July 2023

As the incidence of prostate cancer (PCa) has increased, screening based on prostate-specific antigen (PSA) has become controversial due to the low specificity of PSA. Therefore, we investigated the diagnostic performance of prostate health index (PHI) density (PHID) for the detection of PCa and clinically significant PCa (csPCa) compared to PSA, PSA density (PSAD), and PHI as a triaging test. We retrospectively reviewed 306 men who underwent prostate biopsy for PSA levels of 2.5 to 10 ng/mL between January 2020 and April 2023. Of all cohorts, 86 (28.1%) and 48 (15.7%) men were diagnosed with PCa and csPCa, respectively. In ROC analysis, the highest AUC was identified for PHID (0.812), followed by PHI (0.791), PSAD (0.650), and PSA (0.571) for PCa. A similar trend was observed for csPCa: PHID (AUC 0.826), PHI (AUC 0.796), PSAD (AUC 0.671), and PSA (0.552). When the biopsy was restricted to men with a PHID ≥ 0.56, 26.5% of unnecessary biopsies could be avoided; however, 9.3% of PCa cases and one csPCa case (2.1%) remained undiagnosed. At approximately 90% sensitivity for csPCa, at the given cut-off values of PHI ≥ 36.4, and PHID ≥ 0.91, 48.7% and 49.3% of unnecessary biopsies could be avoided. In conclusion, PHID had a small advantage over PHI, about 3.6%, for the reduction in unnecessary biopsies for PCa. The PHID and PHI showed almost the same diagnostic performance for csPCa detection. PHID can be used as a triaging test in a clinical setting to pre-select the risk of PCa and csPCa.
Multiomics Strategy Reveals the Mechanism of Action and Ameliorating Effect of Deer Velvet Antler Water Extracts on DSS-Induced Colitis
Authors: Hung Ying-Kai , Ho Shang-Tse , Kuo Ching-Yun , Chen Ming-Ju
Published: July 2023

Velvet antler is a precious traditional Chinese medicine used for thousands of years. This study investigated the anti-colitis effects of water extracts of Formosan sambar deer (SVAE) and red deer (RVAE) to identify the possible mechanisms and the bioactive compounds using a dextran sulfate sodium (DSS)-induced colitis mouse model. The mechanism of action and the ameliorating effects of SVAE and RVAE on DSS-induced colitis were evaluated using a mouse model. Ultra-high performance liquid chromatography-mass/mass and gas chromatography-mass/mass were applied to identify the bioactive components of the SVAE and RVAE water extracts. The results revealed that both high-dose SVAE and RVAE could ameliorate the symptoms of colitis due to reduced systemic inflammatory responses, enhanced intestinal barrier integrity by restoration of tight junction proteins, and improved gut dysbiosis. The potentially bioactive components of SVAE and RVAE were identified as small molecules (<3 kDa). Further identification by untargeted metabolomics analysis suggested that l-carnitine, hypoxanthine, adrenic acid, creatinine, gamma-aminobutyric-lysine, oleic acid, glycine, poly-γ-glutamic acid, and eicosapentaenoic acid in VAWEs might be involved in ameliorating the symptoms of colitis. This study provided evidence for the potential usage of SVAE and RVAE as anti-colitis agents.
Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation
Authors: Zhao Jie , Tian Geng , Qu Haibin
Published: July 2023

Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes. It has attracted more and more interest nowadays due to its high efficiency, robustness, and applications. To improve both the product quality and process efficiency, the process understanding is critical. This article reviews the recent work in process understanding and optimization for TSWG. Various aspects of the progress in TSWG like process model construction, process monitoring method development, and the strategy of process control for TSWG have been thoroughly analyzed and discussed. The process modeling technique including the empirical model, the mechanistic model, and the hybrid model in the TSWG process are presented to increase the knowledge of the granulation process, and the influence of process parameters involved in granulation process on granule properties by experimental study are highlighted. The study analyzed several process monitoring tools and the associated technologies used to monitor granule attributes. In addition, control strategies based on process analytical technology (PAT) are presented as a reference to enhance product quality and ensure the applicability and capability of continuous manufacturing (CM) processes. Furthermore, this article aims to review the current research progress in an effort to make recommendations for further research in process understanding and development of TSWG.
Migration-Associated Transportome and Therapeutic Potential in Glioblastoma Multiforme (GBM)
Authors: Vaid Samir , Schmidt Mirko H. H.
Published: July 2023

GBM is a highly aggressive and very common malignant form of primary brain tumors in adults [...]
The Effect of Aspirin Use on Incident Hepatocellular Carcinoma—An Updated Systematic Review and Meta-Analysis
Authors: Abdelmalak Jonathan , Tan Natassia , Con Danny , Eslick Guy , Majeed Ammar , Kemp William , Roberts Stuart K.
Published: July 2023

An increasing number of observational studies have described an association between aspirin use and a reduced risk of incident hepatocellular carcinoma. We performed this meta-analysis to provide a comprehensive and updated aggregate assessment of the effect of aspirin on HCC incidence. Two independent authors performed a systematic search of the literature, utilising the Medline, Embase, Scopus, and PubMed databases. A total of 16 studies (12 cohort studies, and 4 case-control studies) were selected for inclusion, with a large number of studies excluded, due to an overlapping study population. The pooled analysis of cohort studies involving a total population of approximately 2.5 million subjects, 822,680 aspirin users, and 20,626 HCC cases demonstrated a 30% reduced risk of HCC associated with aspirin use (adjusted HR 0.70, 95%CI 0.60–0.81). There was a similar but non-significant association observed across the case-control studies (adjusted OR 0.60, 95%CI 0.32–1.15, p = 0.13), which involved a total of 1961 HCC cases. In a subgroup meta-analysis of patients with cirrhosis, the relationship between aspirin use and incident HCC diminished to non-significance (adjusted HR 0.96, 95%CI 0.84–1.09). Aspirin use was associated with a statistically significant increase in bleeding events when all relevant studies were pooled together (adjusted HR 1.11, 95%CI 1.02–1.22). Prospectively collected data should be sought, to define the optimal patient group in which aspirin is safe and effective for the chemoprophylaxis of HCC.
Breast Lesions of Uncertain Malignant Potential (B3) and the Risk of Breast Cancer Development: A Long-Term Follow-Up Study
Authors: Bellini Chiara , Nori Cucchiari Jacopo , Di Naro Federica , De Benedetto Diego , Bicchierai Giulia , Franconeri Andrea , Renda Irene , Bianchi Simonetta , Susini Tommaso
Published: July 2023

Breast lesions of uncertain malignant potential (B3) are frequently diagnosed in the era of breast cancer (BC) screening and their management is controversial. They are generally removed surgically, but some international organizations and guidelines for breast research suggest follow-up care alone or, more recently, propose vacuum-assisted excision (VAE). The risk of upgrade to BC is known, but very little data exist on its role as risk factor for future BC development. We analyzed 966 B3 lesions diagnosed at our institution, 731 of which had long-term follow-up available. Surgical removal was performed in 91%, VAE in 3.8%, and follow-up in 5.2% of cases. The B3 lesions included flat epithelial atypia (FEA), atypical ductal hyperplasia (ADH), lobular intraepithelial neoplasia (LIN), atypical papillary lesions (PLs), radial scars (RSs), and others. Overall, immediate upgrade to BC (invasive or in situ) was 22.7%. After long-term follow-up, 9.2% of the patients were diagnosed with BC in the same or contralateral breast. The highest risk was associated with ADH diagnosis, with 39.8% of patients upgraded and 13.6% with a future BC diagnosis (p < 0.0001). These data support the idea that B3 lesions should be removed and provide evidence to suggest annual screening mammography for women after a B3 diagnosis because their BC risk is considerably increased.
In Situ Entrapment of Catalase within Macroporous Cryogel Matrix for Ethanol Oxidation: Flow-through Mode versus Batch Reactor
Authors: Akbayeva Dina N. , Smagulova Indira A. , Maksotova Kuralay S. , Bakirova Botagoz S. , Tatykhanova Gulnur S. , Kudaibergenov Sarkyt E.
Published: July 2023

In this article, the biocatalytic oxidation of ethanol into acetaldehyde was studied using a catalase entrapped within a monolithic polyampholyte cryogel, p(APTAC-co-AMPS), as catalyst. When an anionic monomer, 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (AMPS), was mixed with a cationic monomer, (3-acrylamidopropyl) trimethylammonium chloride (APTAC), under cryo-polymerization conditions at a molar ratio of monomers [APTAC]:[AMPS] = 75:25 mol.% in the presence of 10 mol.% cross-linking agent, N,N-methylenebisacrylamide (MBAA), the macroporous polyampholyte cryogels containing various amounts of catalase were synthesized in situ. The conversion of ethanol into acetaldehyde in good-to-high yields was observed in flow-through and batch-type reactors under optimal conditions: at T = 10–20 °C, pH = 6.9–7.1, [C2H5OH]:[H2O2] = 50:50 vol.%. According to the SEM images, the pore sizes of the p(AMPS-co-APTAC) cryogel vary from 15 to 55 μm. The catalytic activity of catalase entrapped within a monolithic polyampholyte cryogel in the conversion of ethanol into acetaldehyde was evaluated through the determination of kinetic parameters such as the Michaelis constant (Km), maximum enzymatic rate (Vmax), activation energy (Ea), turnover number (TON) and turnover frequency (TOF). The catalase encapsulated within the monolithic polyampholyte cryogel exhibits a high conversion of ethanol into acetaldehyde. The key parameters of ethanol oxidation in flow and batch reactors in the presence of the cryogel monolith were calculated.
Prioritizing Use Cases: A Systematic Literature Review
Authors: Odeh Yousra , Al-Saiyd Nedhal
Published: July 2023

The prioritization of software requirements is necessary for successful software development. A use case is a useful approach to represent and prioritize user-centric requirements. Use-case-based prioritization is used to rank use cases to attain a business value based on identified criteria. The research community has started engaging use case modeling for emerging technologies such as the IoT, mobile development, and big data. A systematic literature review was conducted to understand the approaches reported in the last two decades. For each of the 40 identified approaches, a review is presented with respect to consideration of scenarios, the extent of formality, and the size of requirements. Only 32.5% of the reviewed studies considered scenario-based approaches, and the majority of reported approaches were semiformally developed (53.8%). The reported result opens prospects for the development of new approaches to fill a gap regarding the inclusive of strategic goals and respective business processes that support scenario representation. This study reveals that existing approaches fail to consider necessary criteria such as risks, goals, and some quality-related requirements. The findings reported herein are useful for researchers and practitioners aiming to improve current prioritization practices using the use case approach.
The Association of Oxaliplatin-Containing Adjuvant Chemotherapy Duration with Overall and Cancer-Specific Mortality in Individuals with Stage III Colon Cancer: A Population-Based Retrospective Cohort Study
Authors: Sue-Chue-Lam Colin , Brezden-Masley Christine , Sutradhar Rinku , Yu Amy Y. X. , Baxter Nancy N.
Published: July 2023

Purpose: Few studies have examined the relationship between duration of oxaliplatin-containing adjuvant chemotherapy for stage III colon cancer and mortality in routine practice. We examined the association between treatment with 50% versus >85% of a maximal course of adjuvant therapy (eight cycles of CAPOX, twelve cycles of FOLFOX) and mortality in stage III colon cancer. Methods: Using linked databases, we identified Ontarians aged ≥18 years at diagnosis of stage III colon cancer between 2007 and 2019. In the primary comparison, we compared patients who received 50% or >85% of a maximal course of adjuvant therapy; in a secondary comparison, we evaluated a dose effect across patients who received FOLFOX in one-cycle increments from six to ten cycles against >85% (more than ten cycles) of a maximal course of FOLFOX. The main outcomes were overall and cancer-specific mortality. Follow-up began 270 days after adjuvant treatment initiation and terminated at the first of the outcome of interest, loss of eligibility for Ontario’s Health Insurance Program, or study end. Overlap propensity score weights accounted for baseline between-group differences. We determined the hazard ratio, estimating the association between mortality and treatment. Non-inferiority was concluded in the primary comparison for either outcome if the upper limit of the two-sided 95% CI was ≤1.11, which is the margin used in the International Duration Evaluation of Adjuvant Chemotherapy Collaboration. Results: We included 3546 patients in the analysis of overall mortality; 486 (13.7%) received 50% and 3060 (86.3%) received >85% of a maximal course of therapy. Median follow-up was 5.4 years, and total follow-up was 20,510 person-years. There were 833 deaths. Treatment with 50% of a maximal course of adjuvant therapy was associated with a hazard ratio of 1.13 (95% CI 0.88 to 1.47) for overall mortality and a subdistribution hazard ratio of 1.31 (95% CI 0.91 to 1.87) for cancer-specific mortality versus >85% of a maximal course of therapy. In the secondary comparison, there was a trend toward higher overall mortality in patients treated with shorter durations of therapy, though confidence intervals overlapped considerably. Conclusion: We could not conclude that treatment with 50% of a maximal course is non-inferior to >85% of a maximal course of adjuvant therapy for mortality in stage III colon cancer. Clinicians and patients engaging in decision-making around treatment duration in this context should carefully consider the trade-off between treatment effectiveness and adverse effects of treatment.
Algal Nanoparticles and Their Antibacterial Activity: Current Research Status and Future Prospectives
Authors: Behera Maheswari , Behera Prateek Ranjan , Bhuyan Prajna Paramita , Singh Lakshmi , Pradhan Biswajita
Published: July 2023

Green nanotechnology is a promising technology that has a wide range of applications in pharmaceuticals today because they offer a higher surface-area-to-volume ratio. Algal-based nanoparticles (NPs) are the subject of intense research interest today for their potential to treat and prevent infections caused by infectious microorganisms that are antibiotic resistant. Algae contain a variety of therapeutically potential bioactive ingredients, including chlorophyll, phycobilin, phenolics, flavonoids, glucosides, tannins, and saponins. As a result, NPs made from algae could be used as therapeutic antimicrobials. Due to their higher surface-area-to-volume ratios compared to their macroscopic components, metallic nanoparticles are more reactive and have toxic effects on their therapy. For pharmaceutical and biomedical applications, green synthesis restricts the use of physical and chemical methods of metallic nanoparticle synthesis, and it can be carried out in an environmentally friendly and relatively low-cost manner. The majority of macroalgae and some microalgae have latent antimicrobial activity and are used in the synthesis of metallic nanoparticles. A potential application in the field of nanomedicine and the establishment of a potential pharmacophore against microorganisms may result from the synthesis of algal-based NPs. Only a few studies have been done on the potential antimicrobial, antifungal, and antibacterial activity of algae-based NPs. As a result, the study will concentrate on the environmentally friendly synthesis of various NPs and their therapeutic potential, with a focus on their antibacterial activity. Thus, the aim of this study is to review all the literature available on the synthesis and characterization of the algal nanoparticles and their potential application as an antibacterial agent.
Performance Analysis of Two Receiver Arrangements for Wireless Battery Charging System
Authors: Kumar Abhay , Jha Rupesh Kumar , Bertoluzzo Manuele , Khadse Chetan B. , Jaiswal Swati , Mulay Gourang , Sagar Amritansh
Published: July 2023

Two different arrangements for Wireless Battery Charging Systems (WBCSs) with a series-parallel resonant topology have been analyzed in this paper. The first arrangement charges the battery by controlling the receiver-side rectifier current and voltage without a chopper, while the second arrangement charges it with a chopper while keeping the chopper input voltage constant. The comparison of these two arrangements is made based on their performance on various figures of merit, such as the sizing factor of both the supply voltage source and receiver coil, overall system efficiency, power-transfer ratio, receiver efficiency, and cost estimation. Later, the simulated study is verified by the experimental setup designed to charge the electric vehicle.
Utility of FDG PET/CT in Patient with Synchronous Breast and Colon Cancer
Authors: Su I-Lin , Chen Yen-Kung
Published: July 2023

The most common malignancy in women is breast cancer, and the second one is colon cancer. Synchronous breast and colon cancers are rare. Here, we reported a 60-year-old woman with a left breast mass for six months. Biopsy revealed an invasive ductal carcinoma. She underwent 2-[Fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan for evaluation of the extent of the disease. FDG PET/CT revealed an advanced left breast cancer with multiple metastases in both regional and distant lymph nodes (in left axilla level I/II, lower paratracheal region, and right lung hilum), bilateral lungs, and axial and proximal appendicular skeletons. An early staged synchronous colon cancer was detected incidentally on FDG PET/CT images. After endoscopic mucosal resection of colon cancer, she received palliative chemotherapy for breast cancer with a marked therapeutic response. The disease status of post-treated breast cancer remained relatively stationary for more than one year. Brain metastasis was noted afterward. Nevertheless, there was no evidence of colon cancer recurrence throughout her breast cancer disease course.
Artificial Intelligence in Renal Cell Carcinoma Histopathology: Current Applications and Future Perspectives
Authors: Distante Alfredo , Marandino Laura , Bertolo Riccardo , Ingels Alexandre , Pavan Nicola , Pecoraro Angela , Marchioni Michele , Carbonara Umberto , Erdem Selcuk , Amparore Daniele , Campi Riccardo , Roussel Eduard , Caliò Anna , Wu Zhenjie , Palumbo Carlotta , Borregales Leonardo D. , Mulders Peter , Muselaers Constantijn H. J.
Published: July 2023

Renal cell carcinoma (RCC) is characterized by its diverse histopathological features, which pose possible challenges to accurate diagnosis and prognosis. A comprehensive literature review was conducted to explore recent advancements in the field of artificial intelligence (AI) in RCC pathology. The aim of this paper is to assess whether these advancements hold promise in improving the precision, efficiency, and objectivity of histopathological analysis for RCC, while also reducing costs and interobserver variability and potentially alleviating the labor and time burden experienced by pathologists. The reviewed AI-powered approaches demonstrate effective identification and classification abilities regarding several histopathological features associated with RCC, facilitating accurate diagnosis, grading, and prognosis prediction and enabling precise and reliable assessments. Nevertheless, implementing AI in renal cell carcinoma generates challenges concerning standardization, generalizability, benchmarking performance, and integration of data into clinical workflows. Developing methodologies that enable pathologists to interpret AI decisions accurately is imperative. Moreover, establishing more robust and standardized validation workflows is crucial to instill confidence in AI-powered systems’ outcomes. These efforts are vital for advancing current state-of-the-art practices and enhancing patient care in the future.
Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker
Authors: Ong Khaa , Hsieh Yao-Yu , Sun Ding-Ping , Huang Steven , Tian Yu-Feng , Chou Chia-Lin , Shiue Yow-Ling , Joseph Keva , Chang I-Wei
Published: July 2023

Intrahepatic cholangiocarcinoma (IHCC) is the second most common malignant neoplasm of the liver. In spite of the increasing incidence worldwide, it is relatively rare in Western countries. IHCC is relatively common in Eastern and Southeastern Asia. Patients with IHCC are usually diagnosed at an advanced stage, therefore, the clinical outcome is dismal. Dysregulation of urea cycle metabolic enzyme expression is found in different types of cancers. Nevertheless, a comprehensive evaluation of genes related to the urea cycle (i.e., GO:0000050) has not been conducted in IHCC. By performing a comparative analysis of gene expression profiles, we specifically examined genes associated with the urea cycle (GO:0000050) in a publicly accessible transcriptomic dataset (GSE26566). Interestingly, CPS1 was identified as the second most prominently down-regulated gene in this context. Tumor tissues of 182 IHCC patients who underwent curative-intent hepatectomy were enrolled. The expression level of CPS1 protein in our IHCC cohort was assessed by immunohistochemical study. Subsequent to that, statistical analyses were carried out to examine the expression of CPS1 in relation to various clinicopathological factors, as well as to assess its impact on survival outcomes. We noticed that lower immunoreactivity of CPS1 in IHCC was associated with tumor progression (pT status) with statistical significance (p = 0.003). CPS1 underexpression was not only negatively correlated to overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS) in univariate analysis but also an independent prognosticator to forecast poorer clinical outcome for all prognostic indices (OS, DSS, LRFS and MeFs) in patients with IHCC (all p ≤ 0.001). These results support that CPS1 may play a crucial role in IHCC oncogenesis and tumor progression and serve as a novel prognostic factor and a potential diagnostic and theranostic biomarker.
Super Formula for Diagnosing Disseminated Intravascular Coagulation Using Soluble C-Type Lectin-like Receptor 2
Authors: Yamamoto Akitaka , Wada Hideo , Tomida Masaki , Ichikawa Yuhuko , Ezaki Minoru , Shiraki Katsuya , Shimaoka Motomu , Iba Toshiaki , Suzuki-Inoue Katsue , Kawamura Masahide , Shimpo Hideto
Published: July 2023

The scoring systems for disseminated intravascular coagulation (DIC) criteria require several adequate cutoff values, vary, and are complicated. Accordingly, a simpler and quicker diagnostic method for DIC is needed. Under such circumstances, soluble C-type lectin-like receptor 2 (sCLEC-2) received attention as a biomarker for platelet activation. Materials and Methods: The diagnostic usefulness of sCLEC-2 and several formulas, including sCLEC-2xD-dimer, sCLEC-2/platelet count (sCLEC-2/PLT), and sCLEC-2/PLT × D-dimer (sCLEC-2xD-dimer/PLT), were evaluated among 38 patients with DIC, 39 patients with pre-DIC and 222 patients without DIC or pre-DIC (non-DIC). Results: Although the plasma level of sCLEC-2 alone was not a strong biomarker for the diagnosis of DIC or pre-DIC, the sCLEC-2xD-dimer/PLT values in patients with DIC were significantly higher than those in patients without DIC, and in a receiver operating characteristic (ROC) analysis for the diagnosis of DIC, sCLEC-2xD-dimer/PLT showed the highest AUC, sensitivity, and odds ratio. This formula is useful for the diagnosis of both pre-DIC and DIC. sCLEC-2xD-dimer/PLT values were significantly higher in non-survivors than in survivors. Conclusion: The sCLEC-2xD-dimer/PLT formula is simple, easy, and highly useful for the diagnosis of DIC and pre-DIC without the use of a scoring system.
A New Analysis of Real-Time Fatality Rate in the Initial Stage of COVID-19
Authors: Zhou Chuanbo , Fang Jiaohong , Mao Mingzhi
Published: July 2023

Mortality is one of the most important epidemiological measures and a key indicator of the effectiveness of potential treatments or interventions. In this paper, a permutation test method of variance analysis is proposed to test the null hypothesis that the real-time fatality rates of multiple groups were equal during the epidemic period. In light of large-scale simulation studies, the proposed test method can accurately identify the differences between different groups and display satisfactory performance. We apply the proposed method to the real dataset of the COVID-19 epidemic in mainland China (excluding Hubei), Hubei Province (excluding Wuhan), and Wuhan from 31 January 2020 to 30 March 2020. By comparing the differences in the disease severity for differential cities, we show that the severity of the early disease of COVID-19 may be related to the effectiveness of interventions and the improvement in medical resources.
The Optimization of the Interior Permanent Magnetic Motor Case Study
Authors: Mociran Bogdan , Topa Vasile
Published: July 2023

This paper presents two optimization methods of an interior permanent magnetic motor (IPM). The first method is based on the non-dominated sorting genetic algorithm II (NSGA-II), while the second one is based on the NSGA-III algorithm. The focus is on the reduction of the cogging torque (CT), which acts upon the rotor when the IPM is not powered, and the current that flows through the three windings is 0. The influence of the CT over the motor operation is a negative one, inducing vibrations that are not desired. The limitation of these influences is the desired way for improvement. The optimizations applied entailed the change of the geometrical configuration of the stator whilst maintaining the exterior dimensions unaltered. Through this simple but robust approach, the performance of the IPM proposed was improved.
Progress on Phenanthroimidazole Derivatives for Light-Emitting Electrochemical Cells: An Overview
Authors: Szlapa-Kula Agata , Kula Slawomir
Published: July 2023

Phenanthroimidazole derivatives are currently frequently used chemical compounds in the active layers of various devices, such as organic light-emitting diodes (OLEDs) or light-emitting electrochemical cells (LECs). Their advantages include simple and cheap synthesis, good solubility in organic solvents, easy processing, high thermal stability, excellent electron transport ability, and very good optical and electroluminescent properties. The construction of the LEC is based on a very simple construction in which the active layer plays a significant role. Thus, the compounds used in it are extremely important because they play the role of more than just emitters. This review summarizes the current state of the art regarding phenanthroimidazole derivatives used in the active layer in LECs. The synthesis of the considered compounds is presented in detail in the first part of the review. Next, research on the physicochemical properties of phenanthroimidazole derivatives is presented. Finally, the latest reports on LEC test devices are presented.
Comparison and Evaluation of Transport Property Prediction Performance of Supercritical Hydrocarbon Aviation Fuels and Their Pyrolyzed Products via Endothermic Reactions
Authors: Hwang Sung-rok , Lee Hyung Ju
Published: July 2023

This study presents results of predicting the transport properties of hydrocarbon aviation fuels and their decomposed products after pyrolysis. Twenty-seven pure substances and two types of mixture, including both low and high molecular weight hydrocarbons as well as hydrogen, are considered. The specified temperature and pressure ranges, 300 to 1000 K and 0.1 to 5.0 MPa, respectively, correspond to representative operating conditions of a hydrocarbon aviation fuel that circulates as a coolant in the regenerative cooling system of a hypersonic vehicle and include the critical temperatures and pressures of most of the hydrocarbon fuels of interest. Four methods are adopted for the prediction of viscosity and thermal conductivity; the Brule-Starling method is used to predict viscosity, the Modified Propane TRAPP method for thermal conductivity, and the Methane TRAPP, Propane TRAPP, and Chung et al. methods are used for both transport properties. A comparison of the total average values concludes that the Chung et al. and Brule-Starling methods perform best in predicting the viscosity of all substances ranging from hydrogen to high molecular weight hydrocarbons in the temperature and pressure ranges specified in the current study. The quantified comparison by the total average also confirms that the Modified Propane TRAPP method best predicts the thermal conductivity of all of the 29 substances over the set temperature and pressure ranges, although the Propane TRAPP and Chung et al. methods offer a similar level of accuracy.
The Effect of Spread Spectrum Modulation on Power Line Communications
Authors: Ustun Ercan Seda , Pena-Quintal Angel , Thomas Dave
Published: July 2023

Interference in Power Line Communication (PLC) is examined in this paper. PLC is a wired communication technology that provides communication and data transmission over the existing electrical network. It uses the electrical wiring in buildings or the electrical grid to transmit data signals between devices, rather than using dedicated communication cables or wireless signals. Many applications employ PLC technologies, which have the benefit of leveraging existing power connections for both power and data transfer, reducing cost and complexity. These interactions may be observed in contemporary smart grids and automobile power networks, where lengthy cables, switching power supplies and communication links all work together but exacerbate Electromagnetic Interference (EMI) problems. This research examines the effects of spread spectrum methods used to reduce EMI from power converters on PLC systems. Spread Spectrum Modulation (SSM) and its three variants, Sine, Random and Sawtooth, are frequently employed to meet the requirements of electromagnetic compatibility, however, there are some repercussions that may be detrimental to the converter or the rest of the electrical network. These outcomes occur for various modulation algorithm settings and at various frequencies. Measurements are made utilising the Frame Error Rate (FER) value provided by the PLC link system to ascertain the interference produced by a Silicon Carbide (SiC)-based DC-DC converter in order to investigate these concerns and standardise an assessment approach. To examine the effect of SSM on reducing EMI in the frequency domain, the peak index of a CISPR-16 EMI receiver is used.
Experimental Modelling of a Floating Solar Power Plant Array under Wave Forcing
Authors: Delacroix Sylvain , Bourdier Sylvain , Soulard Thomas , Elzaabalawy Hashim , Vasilenko Polina
Published: July 2023

Floating Photovoltaic (FPV) plants are already well developed, and deployed all over the world, on calm water inland lakes, or in sheltered locations. They are now progressing to be installed in nearshore sites, and in deep water seas. The company HelioRec, developing floating modules to form FPV arrays to be deployed in nearshore areas, was awarded free-of-charge testing of their system by the Marine Energy Alliance (MEA) European program. This paper describes the experimental testing of the 1:1 scale float system, composed of 16 floating modules supporting solar panels and three footpaths, carried out in Centrale Nantes’ ocean wave tank, allowing regular and irregular frontal and oblique wave conditions. Experimental results show that, even in the narrow wave spectrum experimentally achievable, a specific response from the array was revealed: the multibody articulated system exhibits a first-order pitch resonant mode when wavelengths are about twice the floater length. A shadowing effect, leading to smaller motions of rear floaters, is also observed, for small wavelengths only.
Offshore Wind Farm in the Southeast Aegean Sea and Energy Security
Authors: Delagrammatikas Georgios , Roukanas Spyridon
Published: July 2023

This paper deals with the creation, in realistic terms, of an offshore wind farm between the Greek islands of Karpathos and Kassos in the Dodecanese complex. In this context, the terms and conditions for the possible existence of an offshore wind park in Greece are analyzed; the technical components of such a project are described; the offshore wind farm, which was designed by the authors, is presented in detail; and the location selected for its installation is assessed. Moreover, the benefits for the islands of Karpathos and Kassos and for the Greek State, as well as financial data adapted to this specific offshore wind farm and SWOT analysis for the two phases of the project, are presented. The authors conclude that an investment in this project would be viable in economic terms and feasible, despite it being a small-scale project.
Assessment of Forest Road Models in Concession Areas in the Brazilian Amazon
Authors: Morais Pricila do Prado , Arima Eugenio Yatsuda , de Souza Álvaro Nogueira , Pereira Reginaldo Sérgio , Emmert Fabiano , Cardoso Rodrigo Montezano , Miguel Eder Pereira , Matricardi Eraldo Aparecido Trondoli
Published: July 2023

Forest management aimed at the sustainable use of forest resources is an alternative land use to deforestation and can improve forest conservation in tropical regions. The construction of forest infrastructure, including forest roads, skid trails, and log-landings, is a key factor in minimizing the impacts and forest disturbances typically caused by selective logging activities in tropical forests. In this study, we used field and secondary data to assess the planned and implemented forest infrastructure in a study site of 5723 hectares under a forest concession in the Caxiuanã National Forest, located in the state of Pará, Brazilian Amazon. We tested alternative modeling approaches (the Tomlin and Spanning Tree models) by comparing them with the previously planned and implemented logging infrastructure by a concessionaire timber company (CEMAL Ltd.) in the study site. Our results indicate that the Tomlin model was the best approach for allocating forest roads in the study area, as it demonstrated the optimal balance between financial costs and forest disturbances for timber extraction. Additionally, Minimum Spanning Tree modeling achieved the most favorable results in delineating secondary roads and skid trails in the study site, despite slightly higher financial costs compared to the minimum acceptable costs. This alternative approach to modeling forest infrastructure can contribute to reducing forest disturbances and increasing the economic and ecological sustainability of forest management in tropical forests.
Isolation of Yeast and LAB from Dry Coffee Pulp and Monitoring of Organic Acids in Inoculated Green Beans
Authors: Zhao Na , Kokawa Mito , Amini Rasool Khan , Dong Weixue , Kitamura Yutaka
Published: July 2023

Yeast and lactic acid bacteria (LAB) are known to play an important role in the fermentation process of coffee post-harvest. This study aimed to isolate and screen yeast and LAB to be applied in lab-scale refermentation of commercial green coffee beans and coffee pulp with the aim of modifying the composition of organic acids (OAs) in coffee beans. Yeast and LAB strains were isolated from green coffee beans and dry coffee pulp and identified, and their effect on OA concentration in the coffee beans was quantified. In addition, the effects of different fermentation conditions (additional carbon source, different inoculum dose, and different types of coffee pulp) were evaluated based on OA quantification. Nine yeast isolates of Rhodotorula mucilaginosa and Wickerhamomyces anomalus were identified, and 11 LAB isolates of the species Enterococcus mundtii were identified. Of the 7 OAs quantified, quinic acid was the most abundant. The inoculation of isolated yeasts and LAB led to higher concentrations of OAs, showing the potential to realize modification of the OA composition of green coffee beans by re-fermentation with coffee-originated isolates.
APOE Gene Associated with Dementia-Related Traits, Depression, and Anxiety in the Hispanic Population
Authors: Xu Chun , Padilla Victoria , Lozano Stephanie , Gamez Daniela , Su Brenda Bin , Wang Xuan , Maestre Gladys , Wang Kesheng
Published: July 2023

Alzheimer’s disease (AD), a main cause of dementia, is commonly seen in aging populations with a strong genetic component. AD is one of the most common neurodegenerative disorders; it is a genetically and clinically heterogeneous disease. Specific demographic factors and genetic variants have been identified in non-Hispanic populations; however, limited studies have observed the Hispanic population. Therefore, we focused on investigating a known gene, APOE, associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population in our current study. A total of 1382 subjects were studied based on data collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N = 62). Questionnaires regarding demographics, medical history, and blood/saliva samples were collected. We genotyped the APOE gene. The current findings indicated that APOE-ε4 was associated with not only AD (p < 0.0001) but also with anxiety (p < 0.0001) and depression (p = 0.0004). However, APOE-ε3 was associated with depression (p = 0.002) in the Hispanic population. We provide additional evidence in which APOE-ε4 increased the risk for AD in Hispanics. For the first time, APOE alleles show increased risks for anxiety and depression in Hispanics. Further research is warranted to confirm the current findings.
Mediating Effect of Humanism on the Relationship between Task Performance Competence and Holistic Nursing Competence for Clinical Nurses
Authors: Yu Junghee , Kim Taehui , Kim Hyesun
Published: July 2023

This is a cross-sectional descriptive study that investigates the mediating effect of humanism on the relationship between task performance and holistic nursing competence among clinical nurses. The participants were nurses with more than one year of work experience in general hospitals in South Korea, recruited using convenience sampling. A total of 227 data samples were collected. A self-reported questionnaire including the task performance competence scale, holistic nursing competence scale, and humanism scale was used for the survey. Data were analyzed using the t-test, analysis of variance, Pearson’s correlation coefficients, and hierarchical multiple regression after checking for normal distribution. The results showed that task performance competence, holistic nursing competence, and humanism differed according to characteristics such as gender, age, educational level, marital status, position, length of career, and job and salary satisfaction. Task performance competence was positively correlated with holistic nursing competence and humanism. A positive correlation was also observed between holistic nursing competence and humanism. A partial mediating effect of humanism in the relationship between task performance competence and holistic nursing competence was confirmed. Thus, to increase nurses’ holistic nursing competence, it is necessary to improve task performance competence and formulate a continuous and repetitive education program that includes humanism.
Psychometric Properties of the Italian Version of the Leader Member Exchange Scale (LMX-7): A Validation Study
Authors: Lommi Marzia , Notarnicola Ippolito , Caruso Rosario , Iacorossi Laura , Gambalunga Francesca , Sabatino Laura , Latina Roberto , Rea Teresa , Guillari Assunta , De Maria Maddalena , Mazzotta Rocco , Rocco Gennaro , Stievano Alessandro , Gualandi Raffaella , Tartaglini Daniela , Ivziku Dhurata
Published: July 2023

For decades, scholars have studied leader–member exchange (LMX) relationships to understand and explain the effects of leadership on follower attitudes and performance outcomes within work settings. One available instrument to measure these aspects is the LMX-7 scale. This measurement has been widely used in empirical studies, but its psychometric properties have been poorly explored. The aim of this study was to test the psychometric characteristics (content, structural and construct validity, and reliability) of the Italian version of the LMX-7 scale and to support its cultural adaptation. We used a cross-sectional multi-center design. The forward–backward translation process was used to develop the Italian version of the scale. The scale was administered through an online survey to 837 nurses and nurse managers working in different settings. The factorial structure was tested using both exploratory and confirmatory factor analyses (EFA and CFA), and reliability was evaluated using Cronbach’s alpha. For the construct validity, we used hypothesis testing and differentiation by known groups. The Italian version of the LMX-7 scale presented one dimension. All the psychometric tests performed confirmed its validity and suggested its usefulness for future research.