bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution and Determinants of Antenatal Care Services Utilization Among Women in Rwanda: a Rapid Review
Authors:   Emile Twagirumukiza1, Bubanje Valens , Girimpundu Revocathe , Sebera Emile
Published: September 2024

Background: Maternal and child health remains a global priority, with antenatal care (ANC) recognized as essential for ensuring positive pregnancy outcomes. Despite significant improvements, ANC utilization in low and middle-income countries, particularly in Sub-Saharan Africa, remains low, contributing to high maternal and neonatal mortality rates. This paper highlighted significant progress in Rwanda's maternal health services since 2000. It further explored the evolution of ANC utilization in Rwanda, identifying key determinants and trends over the past two decades.
Methods: Following a traditional maternal and child health services contextualization in Rwanda, a rapid review was conducted, searching databases such as PubMed, Google Scholar, and Scopus, alongside grey literature and reference lists. The review focused on studies published between 2010 and 2024, examining factors associated with ANC utilization in Rwanda. The screening was independently conducted by two reviewers with the assistance Rayyan application, followed by full-text screening and data synthesis. The results were presented using the forest plots to display the significant odd ratios of ANC services utilization across different predictor variables.
Results: The review included 11 studies and 1 report revealing a significant improvement in ANC utilization in Rwanda. By 2019-2020, 47% of women received ANC in the first trimester, and 59% had four or more visits, compared to 35% and 38%, respectively, in 2010.
Factors positively associated with adequate ANC included higher education levels, better wealth status, health insurance coverage, and small household size. Conversely, significant distance to health facilities and unwanted pregnancies were associated with lower odds of adequate ANC utilization. Delayed ANC was more likely among women with higher parity, those who lack social support, and those with no or only primary education.
Conclusion: The findings indicate that Rwanda has made considerable strides in improving ANC utilization. Addressing barriers such as distance to healthcare facilities, education, and economic disparities is crucial for further enhancing maternal and child health outcomes. The review underscores the need for targeted interventions to achieve WHO recommendations of 8 ANC visits and Sustainable Development Goals (SDGs) related to maternal and child health in Rwanda.
Electrooculography features of reticular macular disease: A preliminary observation
Authors: Qi Ren , Zhe Chu , Hao Cheng
Published: September 2024

In this single center retrospective study, we aimed to observe the characteristics of resting potentials between RPE and photoreceptors in RMD patients, based on electrooculography. Seven patients with diffuse RMD diagnosed using infrared fundus photography and optical coherence tomography (OCT) were consecutively reviewed. All 7 patients (14 eyes) underwent routine ophthalmic examinations and were examined by OCT and Electrooculography (EOG). The EOG recordings of the 14 eyes revealed that dark adaptation took 7.21 ± 1.75 minutes to achieve dark trough, whereas light adaptation took 15.79 ± 2.70 minutes from light rise to the light peak. Furthermore, the amplitude of dark trough potential was 262.0–962.1 µV, whereas that of light peak potential was between 373.8 µV and 1.8 mV. In addition, the LP:DT ratio of the 14 eyes observed in this preliminary study was 1.63 ± 0.22, ranged between 1.18 and 1.97, which was lower than 2.35, but was not significantly lower than the lower limit of 1.7 (t = -1.12, P = 0.28). In conclusion, Some EOG parameters of RMD patients are different from normal reference ranges, bioelectric activity between RPE and photoreceptors in patients with RMD may be affected by SDD or RPE abnormalities.
Age-related changes in the hair follicle and hair shaft in women in the parietal region
Authors: Balandin A. A. , Yudina V. V. , Balandina I. A. , Patrakova S. P. , Korovyakovskaya N. M.
Published: September 2024

Introduction.Medical trichology is a promising and modern direction of cosmetology, engaged in the study of the scalp and hair, both in the state of health and various diseases. However, with all the variety of various scientific publications, there are very few works devoted to the study of morphological changes in normal physiological aging of a person.

Aim.To reveal the dynamics of morphological changes in the hair bulb and hair shaft in women in the parietal region to elderly age.

Materialsandmethods.The work is based on the results of microscopic examination of 80 women, the study sample consisted of conditionally healthy individuals. The examined women were divided into three groups depending on their age. The first group included 27 women of the first period of mature age (26.9 ± 0.70 years). The second group consisted of 30 women of the second period of mature age (47.1 ± 1.20 years). The third group was formed by 23 women of old age (62.1 ± 1.09 years). Hair sampling was performed in the parietal region of the head by combing out the hair that had already fallen out (without pulling it out of the skin!). The width of the hair bulb and hair shaft were measured. The percentage of bulbs containing an internal root sheath to the total number of bulbs was calculated.

Resultsanddiscussion.With age, a decrease in the number of hair follicles with internal root sheath (p < 0.01) along with a tendency to decrease the width of the hair follicle and hair shaft (p > 0.05) was noted in women in the parietal region.

Conclusions.The results of this study add to the information available in the scientific literature about age-related changes occurring in the hair bulb and hair shaft in women by old age. The data obtained will be useful for trichologists in medical practice to create clinical recommendations for the early prevention of age-related alopecia areata.
A preservação da cadeia de custódia aplicada às investigações corporativas internas: Uma reflexão a respeito dos regramentos instituídos pelo pacote anticrime
Authors: Bordini Bruna Goffi da Costa , Guaragni Fabio Andre , Stocco Bruna
Published: September 2024

O trabalho pretende abordar as investigações corporativas internas como mecanismo de compliance dos entes coletivos, e analisar a possível aplicação do regramento da preservação da cadeia de custódia a esse ambiente. Para tanto, realizará breves apontamentos sobre o instituto do compliance e das investigações internas, além de perpassar o regramento da preservação da cadeia de custódia contido no Código de Processo Penal, e instituído pela Lei 13.964/2019, o chamado Pacote Anticrime. Por fim, o que se almeja é refletir sobre a aplicabilidade de tais regras de preservação da cadeia de custódia ao ambiente corporativo, e, em sendo aplicável, analisar eventuais benefícios daí decorrentes, tanto ao ente coletivo como ao Estado, principal interessado na solução de crimes. Utilizou-se da metodologia de pesquisa bibliográfica, legislativa e jurisprudencial.
IMPORTÂNCIA DOS ELEMENTOS DE MEMÓRIA NO AMBIENTE URBANO
Authors: Cruz Terra Jussara Gabriel Cruz Terra Gabriel
Published: September 2024

Muitas das vezes, o processo de urbanização das cidades contemporâneas acontece sem considerar a relação entre as construções históricas e as construções novas. É verdade que em muitos casos existe, por parte do poder público e de comunidades locais, o desejo de preservar o patrimônio histórico. Sabe-se também que o tombamento é um dos instrumentos legais para a preservação patrimonial porém ele sozinho não é suficiente devido a diversas outras condicionantes e variáveis, como estado de conservação, ausência de manutenção preventiva e corretiva, destinação de novos usos, ação de vandalismo dentre outros. Entende-se que quando a comunidade local está envolvida e engajada na preservação do bem, as ações de conservação costumam ter resultados mais satisfatórios. Neste trabalho será demonstrada a importância de preservar o legado vivido pela comunidade local através de suas construções históricas. Foram feitas pesquisas no campo das Neurociências para entender como a existência e presença do patrimônio construído afeta o imaginário, o psicológico e a memória da comunidade local. Após as pesquisas feitas, foi possível compreender conceitos importantes como qualia, wayfinding e psicologia ambiental, e com isso, afirmar que as construções históricas têm um papel relevante na construção de memórias, fundamento de crenças, formação de imaginário e bem-estar psicológico dos usuários. Deste modo é correto afirmar que a manutenção e preservação de edifícios de interesse histórico podem servir de estímulos para evocar memórias, sensações e percepções, contribuindo para uma comunidade atenta, com relação saúdavel com sua história, crenças e tradições, que tem conhecimentos de seu passado.
Targeting Fructosamine Oxidase (Amadoriase II) in Aspergillus fumigatus: Comprehensive Virtual Screening, ADMET Analysis, and Molecular Dynamics Simulation of Triazole Derivatives
Authors: Yamari Imane , Abchir Oussama , Khedraoui Meriem , Errougui Abdelkbir , Talbi Mohammed , Samadi Abdelouahid , Kouali MHammed El , Chtita Samir
Published: September 2024

Introduction:

Aspergillus fumigatus, a significant fungal pathogen, poses a
threat to human health, especially in immunocompromised individuals. Addressing the
need for novel antifungal strategies, this study employs virtual screening to identify potential
inhibitors of Fructosamine oxidase, also known as Amadoriase II, a crucial enzyme
in A. fumigatus (PDB ID: 3DJE).

Method:

Virtual screening of 81,197 triazole derivatives was subjected to computational
analysis, aiming to pinpoint molecules with high binding affinity to the active site of
Fructosamine oxidase. Subsequently, an in-depth ADMET analysis assessed the pharmacokinetic
properties of lead compounds, ensuring their viability for further development.
Molecular dynamics simulations were performed to evaluate the stability of top-ranked
compounds over time.

Results:

The results unveil a subset of triazole derivatives displaying promising interactions,
suggesting their potential as inhibitors for further investigation.

Conclusion:

This approach contributes to the development of targeted antifungal agents,
offering a rational starting point for experimental validation and drug development
against Aspergillus fumigatus infections.
Phytochemicals and Nanotechnology: A Powerful Combination against Breast Cancer
Authors: Shafi Sadat , Ahmed Faraha , Waheed Ayesha , Ahmad Syed Sufiyan , Khan Sana , Khan Mohammad Ahmed , Pottoo Faheem Hyder , Rabbani Syed Arman , Singh Shailja , Najmi Abul Kalam
Published: September 2024

Considerable advancements have been made in breast cancer therapeutics in the past few
decades. However, the advent of chemo-resistance and adverse drug reactions coupled with tumor
metastasis and recurrence posed a serious threat to combat this lethal disease. Novel anti-cancer
agents, as well as new therapeutic strategies, are needed to complement conventional breast cancer
therapies. The quest for developing novel anti-cancer drugs caused an upsurge in exploring and harnessing
natural compounds, especially phytochemicals. Various research groups have explored and
documented the anti-cancer potential of wide variety of phytochemical groups including flavonoids
(curcumin, kaempferol, myricetin, quercetin, naringenin, apigenin, genistein epigallocatechin gallate),
stilbenes (resveratrol), carotenoids (crocin, lycopene, lutein), and anthraquinone (Emodin).
However, low chemical stability, poor water solubility, and short systemic half-life impede their
clinical utility. The implication of nano-technological approaches to decode the pharmacokinetic
challenges associated with phytochemical usage, as well as selective drug targeting, have markedly
enhanced the pre-clinical anti-cancer activity, thus aiding in their clinical translation. This review
documented the recent advances in utilizing phytochemicals for breast cancer prevention and lipidbased
nanotechnological approaches for circumventing their pharmacokinetic concerns to enhance
their systemic availability, cytotoxicity, and targeted delivery against breast cancer alone as well as
in combination with conventional therapeutic agents.
Predicting and Validating the Mechanism of Action of the Enema Formula in Treating Colorectal Cancer by Using Network Pharmacology, GEO, and TCGA Databases
Authors: Mu Bai-xiang , Li Yuan xiang , Zhou Hua jian , Zhou Jin-yong , Chen Min , Ye Ningyuan
Published: September 2024

Background:

The GCF, created by Professor Liu Shenlin, an esteemed expert in traditional
Chinese medicine, is rooted in principles to improve blood flow, relieve blood congestion,
clear heat, and detoxify the body. Developed as an empirical formula, it holds significance in
CRC treatment.

Objective:

This study aimed to predict and confirm the active elements, possible targets, and
molecular mechanisms against colorectal cancer (CRC) in the GCF enema formula.

Methods:

Using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis
Platform (TCMSP), we screened active elements and drug targets. Colorectal cancer (CRC)-related
targets were collected from the Online Mendelian Inheritance in Man (OMIM) database, Disease
Gene Network (DisGeNET) database, and Therapeutic Target Database (TTD). The overlap
between action targets of all active elements and CRC-related targets was determined to find common
targets. A Protein-Protein Interaction (PPI) network of common targets was built using the
String database, and Cytoscape software was used for visual analysis to identify core targets. Simultaneously,
the common targets were analyzed using the Metascape database for Gene Ontology
(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Additionally, core
targets and active elements were tested using Discovery Studio 2019 for molecular docking. Furthermore,
the expression differences and prognostic impacts of core targets were examined across
various cancer databases.

Results:

Screening revealed 90 active elements and 251 drug targets in the GCF. There were 6113
disease targets, with 113 common targets between CRC and the GCF. Core targets identified
through PPI analysis included AKT1, STAT3, MYC, SRC, EGFR, and IL6. KEGG enrichment
analysis uncovered 101 relevant pathways related to these targets. Molecular docking experiments
confirmed favorable interactions between core targets and multiple active elements in the GCF.
Additionally, examination of the Human Protein Atlas (HPA) database highlighted differential expression
of core targets MYC and EGFR in normal colorectal tissue compared to CRC tissue.

Conclusion:

The GCF, comprising a combination of three drugs, appears to counteract CRC by influencing
core targets, such as AKT1, STAT3, MYC, SRC, EGFR, and IL6. This process involves
regulating multiple cancer-related signaling pathways, notably the PI3K-AKT pathway.
Osteoarthritis: An Update on Diagnosis & Management
Authors: Jhangiani Palak , Jain Swidhi , Neha Kumari , Wakode Sharad
Published: September 2024

Osteoarthritis (OA) is the most prevalent joint condition. It is a progressively degenerating
disease that involves the entire joint, including the articular cartilage, subchondral bone, ligaments,
capsule, synovial fluid, and periarticular muscles. Physicians understand that osteoarthritis
is diagnosed late during the illness, which may be too late for patients to receive significant benefits
from medications that change their condition. The goals of OA therapy are to preserve function
while minimizing pain and stiffness. This article focuses on the current and potential treatments
for osteoarthritis and various diagnostic methodologies for this disease. In the coming
years, despite having numerous treatments for symptomatic relief, the treatment plan should be
more specialized because everyone might experience improved outcomes.
Pulmonary Protective Effects of Vitamin D and N-Acetylcysteine on Paraquat-Induced Lung Toxicity in Rats: Modulation of Oxidant / Antioxidant Balance
Authors: Ranjb Akram , Moridi Heresh , Mardukhrohani Hanane , Khademi Peyman , Gholami Hamid , Kheiripour Nejat , Tamri Pari , Soleimani Asl Sara
Published: September 2024

Background:

Paraquat (PQ) is one of the most common herbicides used in agriculture
that can lead to very acute toxicity in mammals. It has been reported that PQ has destructive effects
on the lungs.

Objective:

We aimed to investigate the effect of N-acetyl Cysteine (NAC) and Vitamin D (Vit D)
on the oxidative toxicity of the lung in subacute paraquat exposure. 36 male albino Wistar rats at 8
weeks were randomly divided into 6 groups (n=6). A control group, a PQ-intoxicated group (5
mg/kg body weight), a Vit D-treated group (2 μg/kg), an NAC-treated group, a PQ (6.25 mg/kg) +
Vit D group, and finally a PQ + NAC group, each was treated for 7 days.

Methods:

In this experimental study, Lipid Peroxidation (LPO), Total Oxidant Status (TOS), Total
Antioxidant Capacity (TAC), Total Thiol Groups (TTG), and Hydroxyproline (Hyp) levels in
lung tissue were evaluated.

Results:

PQ exposure resulted in a substantial elevation of LPO, TOS, and Hyp levels. Conversely,
TAC and TTG content demonstrably declined. Administration of either PQ+Vit D or
PQ+NAC significantly reduced LPO, TOS, and Hyp levels in the PQ-exposed rats compared to
the PQ group alone. Conversely, TAC and TTG content significantly increased in these groups.
These findings suggest that both vitamin D and NAC may function as free radical scavengers and
potential antioxidant agents, potentially alleviating the detrimental effects of PQ poisoning on the
lungs.

Conclusion:

The present study has demonstrated the administration of Vit D and NAC to significantly
mitigate PQ-induced lung injury in rats. This protective effect can be likely attributed to
their modulation of the oxidant/antioxidant balance, as evidenced by reductions in LPO, TOS, and
Hyp levels, alongside increases in TAC and TTG content. These findings suggest that vitamin D
and NAC may function as free radical scavengers and antioxidant enhancers, offering protection
against PQ-induced oxidative stress and subsequent lung tissue damage.
Carboxymethyl Chitosan-based Nanomaterials for Biomedical Applications: An Overview of Recent Advances and Prospects
Authors: Vosoughi Pegah , Naghib Seyed Morteza , Mozafari M. R.
Published: September 2024

Chitin is widely recognized as a highly abundant polymer found throughout the planet.
This serves as a fundamental basis for the production of chitosan through deacetylation. Chitosan
is non-toxic and biodegradable, making it highly suitable for applications as a biomaterial and in
the development of drug delivery systems. However, the limited solubility of chitosan in neutral or
alkaline environments has hindered its use in pharmacology and biology. Chitosan can undergo
carboxymethylation, which enhances its water solubility while maintaining its biodegradability
and compatibility with living organisms. Carboxymethyl chitosan (CMC) is a derivative of chitosan
that is soluble in water and exhibits enhanced biological and physicochemical properties
compared to chitosan. The CMC, or modified CMC, is a highly versatile agent with many applications.
It has shown great promise in drug delivery, wound healing, bioimaging, biosensors, tissue
engineering, and gene therapy. This study investigates the properties and potential applications of
materials derived from carboxymethyl chitosan. These materials have attracted significant interest
due to their versatility and fascinating possibilities in biomedical nanodevices and controlledrelease
medication formulations.
Comparative Studies of Benzimidazoles Synthetic Routes and its Biological
Activity
Authors: M. Al-Mahadeen Mohammed , Jaber Areej M.
Published: September 2024

Benzimidazole, discovered in 1872, is a heterocyclic compound noted for its pharmacological activities. It and its derivatives can be synthesized through methods such as condensation
reactions and using nano-based nanoparticles as catalysts. Recent environmentally friendly methods include microwaves, ultrasound, and photochemical reactions. its derivatives are known for
their diverse medicinal applications

Benzimidazole and its derivatives are versatile compounds with a wide range of pharmacological
activities. Their synthesis has evolved over time, incorporating various environmentally friendly
methods such as microwave, ultrasound, and photochemical reactions. The continued exploration
of these compounds and their synthesis methods holds great promise for the development of new
and effective medicinal applications.

Here, we provide an overview of benzimidazole, highlighting its historical significance, various
synthesis methods, and extensive range of pharmacological activities. It aims to emphasize the importance of benzimidazole and its derivatives in medicinal chemistry and their potential therapeutic
applications. The review also notes the development of environmentally friendly synthesis techniques, reflecting advancements in the field.
High Protein Functional Breads for Sustainable Nutrition: A Futuristic Review
Authors: Wijewardhana U.S. , Jayasinghe M.A. , Wijesekara I. , Ranaweera K.K.D.S.
Published: September 2024

Bread is consumed by almost every household worldwide as a dietary staple. Most
commercial bread products are made with refined wheat flour and have an incomplete nutritional
profile. Refined wheat bread is comparatively lower in protein with an unbalanced amino acid
profile and is low in fibre, vitamins, minerals, and phytochemicals. The enrichment of bread to
increase nutritional quality and functionality while preserving sensory properties has been a point
of interest for decades. Legumes and pulses are nutrient-dense plant ingredients capable of increasing
and balancing the nutritional value of bread, especially the protein quality. The review aims to
explore possible legumes and pulses for bread enrichment and recent developments in the study
area, balancing the amino acid profile of bread, the behaviour of legume anti-nutritional factors in
bread making, enhancing protein metabolism, associated challenges, and future directions. The
Enrichment of bread with legumes and pulses will ensure a high protein intake, a balanced amino
acid profile, and additional vitamin, mineral, and phytochemical content compared to refined
wheat bread. The development and commercialization of enriched functional bread products will
benefit a vast population, especially in developing countries.
Concetualizar a inovação enquanto processo fundacional da transformação da escola
Authors: Serra Lídia , Alves José , Soares Diana
Published: September 2024

Múltiplos estudos vêm sendo realizados sobre as dificuldades, as possibilidades e a sustentabilidade da mudança, bem como sobre o conservadorismo e a resiliência dos sistemas educativos. A inovação vem assumindo uma centralidade neste processo de mudança, por ser considerada um fator potenciador da transformação pedagógica, um pequeno elo de uma cadeia de necessárias metamorfoses que abarcam, de forma sistémica, toda a organização escolar. Nesta revisão narrativa de literatura foi concretizada uma abordagem histórico-social relativa ao conceito de inovação, visando sustentar a concetualização do construto, segundo duas dimensões: a ontológica e a epistemológica. Neste alinhamento, propomos um modelo diagramático e uma definição de inovação que sumarizam a essência plural do processo inovativo em educação. A definição de inovação, considerada a sua natureza multidimensional e o seu caráter sistémico e dinâmico, assenta em cinco eixos: o âmbito; o objeto; a responsabilidade, entendida como capacitação organizacional; o foco; e o percurso.
Nesta revisão narrativa de literatura foi concretizada uma abordagem histórico-social relativa ao conceito de inovação, visando sustentar a concetualização do construto segundo duas dimensões, a ontológica e a epistemológica. Neste alinhamento, propomos um modelo diagramático e uma definição de inovação que sumarizam a essência plural do processo inovativo em educação. A definição de inovação, considerada a sua natureza multidimensional e o seu carater sistémico e dinâmico, assenta em cinco eixos: o âmbito, o objeto, a responsabilidade entendida como capacitação organizacional, o foco e o percurso.
Greek and "The Lady of Christ's College": Latin–Greek Code-Switching in John Milton's Prolusion VI.
Authors: Evans Tomos
Published: September 2024

This article explores the Latin–Greek code-switching in arguably the most famous passage of all Milton’s Prolusions: the autobiographical section in which Milton addresses his peculiar nickname at Christ’s College, Cambridge: the “Lady” (Domina). Milton’s transitions from Latin into Greek are not simply ways of heightening the Latin oration’s erudite register, but rather Milton’s Latin–Greek code-switching is part of a wider rhetorical strategy which he employs for conveying states of change, transition, and transgression especially with respect to gender and masculinity. This article scrutinizes the allusive texture of Milton’s forays into Greek in Prolusion VI and explores what this can reveal about the young Milton’s self-representation. Despite the prominence of Greek in the autobiographical section of Prolusion VI, the specific role that Greek plays within Milton’s design of one of the most significant and challenging revelations that Milton ever makes about himself has not been an object of study before.
Enhancing spectral efficiency in uplink/downlink channels of multi-cell massive MIMO for 5G networks
Authors:   Department of Electrical Engineering, Superior University, Lahore 54000, Pakistan, Asif Rao Muhammad , Rehman Ateeq Ur ,   School of Computing, Gachon University, Seongnam 13120, South Korea, Guizani Sghaier ,   Electrical Engineering Department, Alfaisal University, Riyadh, Saudi Arabia, Hamam Habib ,   Department of Electrical and Electronic Engineering Science, School of Electrical Engineering, University of Johannesburg, Johannesburg 2006, South Africa,   Faculty of Engineering, Uni de Moncton, Moncton, NB E1A3E9, Canada,   Faculty of Graduate Studies and Research, Hodmas University College, Taleh Area, Mogadishu, Somalia,   Sector of Research and Innovation, Bridges for Academic Excellence, Tunis, Centre-Ville 1002, Tunisia
Published: September 2024

Massive multiple-input multiple-output (MIMO) systems are at the forefront of 5G technology, significantly improving energy efficiency compared to earlier wireless communication systems. This study develops an optimal model for energy-efficient massive MIMO systems, aiming to increase spectral efficiency (SE) within a multi-cell framework. Base stations (BSs) use various techniques for channel estimations during uplink (UL) transmission, including minimum mean-squared error (MMSE), Least Squares, and Element-wise MMSE (EW-MMSE) estimators. The research evaluates the SE achievable through MMSE channel estimation by applying different receive combining schemes. Additionally, it explores downlink (DL) transmission using various precoding schemes, utilizing vectors similar to those in combining schemes. Simulations show a significant improvement in SE by advancing UL and DL transmission models. The study highlights that optimized MMSE channel estimation, along with an increased number of BS antennas and the ability to serve multiple user equipment (UEs) per cell, can enhance the average SE per cell. The findings indicate that optimizing channel estimation is crucial for the development of massive MIMO systems, especially for improving SE in both UL and DL transmissions.
POLYCYSTIC OVARY SYNDROME AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
Authors: Safarova Sain
Published: September 2024

Considering the metabolic and hormonal changes associated with polycystic ovary syndrome (PCOS), their potential affect bone health has been proposed. The aim of the current study was to evaluate the effect of several hormonal and metabolic alterations associated with polycystic ovary syndrome on bone in postmenopausal women.
Materials and methods: The study included 56 patients with PCOS and 42 women without this disease aged 50–65 years. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) of the lumbar spine and femoral neck. Serum levels of amino-terminal propeptide of procollagen 1 (P1NP) and carboxy-terminal telopeptide of type I collagen (b-CTx), as well as levels of parathyroid hormone (PTH), vitamin D (25(OH)D3), anti-Mullerian hormone (AMH), insulin, testosterone (T), 17-hydroxyprogesterone (17-OHP), dehydroepiandrostenedione sulfate (DHEAS), follicle stimulating hormone, luteinizing hormone, and estradiol were determined. The HOMA-IR index and anthropometric indicators were calculated.
Statistical data were analyzed by nonparametric testing using BioStat Pro 6.2.2.0 software (AnalystSoft Inc., Walnut, USA). Quantitative data are presented as median and quartiles 1 and 3 (Me [Q1; Q3]); The significance of intergroup differences was established using the Mann–Whitney U test (p<0.05). To identify relationships between indicators, a univariate analysis was carried out with the calculation of the Spearman rank correlation coefficient (r).
Results. Women with PCOS had late-onset menopause (p=0.007) and a higher body mass index (BMI, p=0.009) than the control group. Additionally, women with PCOS had higher levels of DHEAS, total T, and 17-OHP than controls. P1NP and b-CTx were significantly different from controls (p=0.028 and p=0.032, respectively). A direct relationship was found between BMI and the activity of the resorption marker b-CTx (r=0.342, p=0.002) and an inverse collinear relationship between AMH values with b-CTx (r=–0.507, p=0.001). BMD in PCOS was higher compared to controls. An inverse relationship exists between BMD of L1–L4 and b-CTx level (r=–0.387, p=0.026) and positive with insulin (r=0.267, p=0.042), AMH (r=0.561, p=0.031) and testosterone (r=0.458, p=0.039). Higher DHEAS levels were associated with higher femoral neck BMD (r=0.473, p=0.035). P1NP was negatively correlated with femoral neck BMD (r=-0.429, p=0.038).
Conclusions. Bone mineral density in women with polycystic ovary syndrome declines more slowly with age compared to their peers, possibly due to the effects of excess androgens and insulin. In postmenopausal women with polycystic ovary syndrome, metabolic processes in bone tissue accelerate, while bone resorption exceeds bone formation. Thus, women affected by polycystic ovary syndrome may be considered at risk of developing osteopenic syndrome.
PRÁTICAS GERENCIAS NO ÂMBITO DA ASSISTÊNCIA JUVENIL
Authors: Souza Gustavo Bruno Pereira de , Loreto Maria das Dores Saraiva de , Bastos Rosária Cal
Published: September 2024

Este artigo propôs refletir, a partir de narrativas de gestores públicos, as ferramentas gerenciais apropriadas pelo público executor do Programa Jovem de Futuro de Viçosa, MG. Além disso, caracteriza as ações assistenciais de intervenção voltadas para o público jovem no município, enfatizando o processo de constituição dessa agenda política na cidade, assim como as maiores dificuldades enfrentadas no processo de concretização dessas ações. Para tanto, foi feito uso de uma abordagem qualitativa, com aplicação de entrevistas individuais semiestruturadas. Os resultados evidenciaram que as ações se constituíram como espaços concebidos para propiciar aos jovens viçosenses possibilidades de formação multidisciplinar. Constatou-se que, a partir do momento em que os problemas foram sendo atenuados pela equipe gestora, através de ações de mitigação, com readequação de suas estruturas, os projetos passaram a ter condições reais de modificar a vida de seu público-alvo.
VERBO ESPERANÇAR E A FORMAÇÃO DE ESTUDANTES/PROFESSORAS TREMEMBÉ NO PARFOR
Authors: Silva Maria do Socorro Sousa e , Faria Ivani Ferreira de
Published: September 2024

Este artigo objetivou refletir sobre a formação das estudantes/professoras Tremembé do Curso de Pedagogia Magistério Intercultural Tremembé, vinculado ao Plano Nacional de Formação de Professores de Educação Básica (PARFOR), realizado pela Universidade Estadual Vale do Acaraú, situada em Sobral/CE. O povo Tremembé está localizado em três municípios do estado, sendo: Itapipoca, Acaraú e Itarema, o último foi o escolhido para este trabalho. A abordagem é qualitativa e exploratória, contou com vivências no curso e a colaboração das estudantes/professoras, as quais compartilharam suas reflexões no primeiro semestre (janeiro/julho) de 2023, período em que o curso se efetivou intensamente para sua culminância. Em suma, foi possível compreender que a formação no Cuiambá e o cunho de esperançar em Freire, foi se desenhando para as estudantes/professoras como uma ferramenta potencializadora para o desenvolvimento dessas profissionais nas escolas indígenas diferenciadas da aldeia.
VIVÊNCIAS NO NOVO ENSINO MÉDIO POR MEIO DO ESTÁGIO SUPERVISIONADO
Authors: Silva Cícera Mônica Rodrigues da , Santos Dinajilas Gomes de Melo , Lacerda Cecília Rosa
Published: September 2024

O trabalho que se apresenta tem como principal objetivo discorrer acerca da experiência no estágio supervisionado V presente na grade curricular do curso de licenciatura em História da Universidade Regional do Cariri – URCA e as discussões englobam a reforma do Ensino Médio proposta pela Lei 13.415/2017. A pesquisa é de caráter qualitativo, tendo como coleta de dados, o levantamento bibliográfico e as vivência em tal estágio. Esse momento propiciado pelo estágio é de suma importância na construção da profissão docente. Ter essa relação entre formação e profissão é crucial para entendermos o sentido da docência, seus percalços e a relação entre escola, educação e sociedade.
CARACTERIZAÇÃO DO CONHECIMENTO FITOPATOLÓGICO DA COMUNIDADE AGRÍCOLA E ESTUDANTIL DO SUDOESTE DO MARANHÃO
Authors: Daniel Barros Silva  , Marcelo Martins Vaz  , Leônidas Leoni Belan
Published: September 2024

Caracterizar o perfil do conhecimento fitopatológico da comunidade agrícola pode orientar práticas de ensino, pesquisa, inovação e extensão para capacitar esse público para o manejo sustentável de doenças em plantas. Para isso, foram entrevistados agricultores e discentes concluintes e ingressantes dos cursos de ciências Agrárias da região Sudoeste do Maranhão e adjacências. Foi possível concluir que existe uma deficiência da comunidade agrícola quanto ao conhecimento fitopatológico e assistência técnica para atender esse público-alvo. Tal fato pode estar ocasionando diagnósticos incorretos e/ou tardios das doenças das culturas agrícolas, e consequentemente manejo de doenças de forma inadequada. Como consequência verificou-se dependência dos defensivos químicos e potencial elevado de danos à produção agrícola. Ademais à situação dos produtores rurais, também foi possível caracterizar deficiência de conhecimento fitopatológico pelos discentes ingressantes ou concluintes. Esses resultados caracterizam demanda por assistência política, técnica e pedagógica.
ANÁLISE DA CONVERSAÇÃO E ANÁLISE DE DISCURSO
Authors: Silva Samuel Barbosa , Dantas Paula Andréa de Oliveira , Souza Francisca Luzia Araujo de
Published: September 2024

Em nossas aulas de Análise da Conversação, fomos estimulados por meio das conversas/interações estabelecidas em sala de aula para a produção textual que contemplasse uma interlocução entre os estudos conversacionais e nossa linha de pesquisa no percurso de doutoramento, esta última, filiada aos estudos discursivos. Diante do desafio exposto, propomo-nos a comentar sobre as possíveis aproximações existentes entre a Análise da Conversação (AC) e a Análise de Discurso (AD) por meio do enunciado. Para tanto, recorremos aos pressupostos metodológicos de revisão bibliográfica dos estudos conversacionais e discursivos fundamentados em Bakhtin (1990), Pêcheux (2014), Marcuschi (1998; 2010), Dionísio (2014), Orlandi (2015), Florêncio (2009) etc. para a discussão deste trabalho.
INTERDISCIPLINARIDADE
Authors: Herpich Natália , Cunha Alexander Montero
Published: September 2024

Os cursos de licenciatura em Ciências da Natureza não possuem uma disciplina científica de referência e, por isso, a interdisciplinaridade se torna um conceito chave para a organização curricular destes. Neste trabalho analisamos como a interdisciplinaridade se faz presente nos Projetos Pedagógicos de dois cursos de licenciatura em Ciências da Natureza com o objetivo de analisar diferentes possibilidades de organização curricular dos referidos cursos que não possuem uma disciplina científica de referência. Nos projetos analisados encontramos duas formas de organização curricular que fizeram referências a interdisciplinaridade com perspectivas distintas: a articulação de disciplinas científicas em componentes curriculares específicos e a proposição de um rol de componentes curriculares que permeiam ambos os cursos. A partir do referencial teórico focado no conceito de interdisciplinaridade, foi possível propor reflexões que agregassem possibilidades de inserção da interdisciplinaridade nos cursos de licenciatura em Ciências da Natureza.
TEMPO LÓGICO DO ALUNO DIANTE DO DISCURSO CAPITALISTA
Authors: Yamazaki Sergio Choiti , Yamazaki Regiani Magalhães de Oliveira
Published: September 2024

Como docentes de disciplinas de cursos de pós-graduação em educação científica, temos vivenciado a experiência de lidar com uma questão repetitiva dos alunos: como utilizar efetivamente certa concepção didática? Neste artigo apontamos para a complexidade da resposta, diante do que Jacques Lacan vai denominar Discurso Capitalista. A pergunta leva a uma demanda por rápida resolução, reforçando as estratégias de ensino roteiristas, que não procuram refletir mais profundamente sobre os significados implícitos, obstaculizando o desenvolvimento de pensamentos mais complexos e distorcendo os pressupostos pela falta de amadurecimento. Além disso, o fundamental para a discussão é a adaptação ao tempo de aprendizagem do aluno, o Tempo Lógico. Com estas duas perspectivas, discurso capitalista e tempo lógico, problematizamos a escola atual, uma vez que tempo lógico e discurso capitalista não se mostram congruentes, dificultando a compreensão de teorias e de sua aplicabilidade.
Psychological Health and Wellness and the Impact of a Supportive Text Messaging Program (Wellness4MDs) Among Physicians and Medical Learners in Canada: Protocol for a Longitudinal Study
Authors: Shalaby Reham , Agyapong Belinda , Dias Raquel , Obuobi-Donkor Gloria , Adu Medard K , Spicer Sharron , Yanchar Natalie L , Agyapong Vincent I O
Published: September 2024

Background

Burnout, anxiety, and depression continue to affect physicians, postgraduate medical trainees, and medical students globally and in Canada particularly after the COVID-19 pandemic.

Objective

The primary goal of this project is to design, implement, monitor, and evaluate a daily supportive SMS text messaging program (Wellness4MDs, Global Psychological e-Health Foundation). The program aims to reduce the prevalence and severity of burnout, anxiety, and depression symptoms among physicians, postgraduate medical trainees, and medical students in Canada.

Methods

This longitudinal study represents a multistakeholder, mixed methods, multiyear implementation science project. Project evaluation will be conducted through a quantitative prospective longitudinal approach using a paired sample comparison, a naturalistic cross-sectional controlled design, and satisfaction surveys. Prevalence estimates for psychological problems would be based on baseline data from self-completed validated rating scales. Additional data will be collected at designated time points for paired comparison. Outcome measures will be assessed using standardized rating scales, including the Maslach Burnout Inventory for burnout symptoms, the 9-item Patient Health Questionnaire for depression symptoms, the 7-item Generalized Anxiety Disorder scale for anxiety symptoms, and the World Health Organization–Five Well-Being Index.

Results

The project launched in the last quarter of 2023, and program evaluation results will become available within 36 months. The Wellness4MDs program is expected to reduce the prevalence and severity of psychological problems among physicians in Canada and achieve high subscriber satisfaction.

Conclusions

The results from the Wellness4MDs project evaluation will provide key information regarding the effectiveness of daily supportive SMS text messages and links to mental health resources on these mental health parameters in Canadian physicians, postgraduate trainees, and medical students. Information will be useful for informing policy and decision-making concerning psychological interventions for physicians in Canada.

International Registered Report Identifier (IRRID)

PRR1-10.2196/44368
Evaluating the Psychometric Properties of a Physical Activity and Sedentary Behavior Identity Scale: Survey Study With Two Independent Samples of Adults in the United States
Authors: Wen Cheng K Fred , Schneider Stefan , Junghaenel Doerte U , Toledo Meynard John L , Lee Pey-Jiuan , Smyth Joshua M , Stone Arthur A
Published: September 2024

Background

Emerging evidence suggests a positive association between relevant aspects of one’s psychological identity and physical activity engagement, but the current understanding of this relationship is primarily based on scales designed to assess identity as a person who exercises, leaving out essential aspects of physical activities (eg, incidental and occupational physical activity) and sedentary behavior.

Objective

The goal of this study is to evaluate the validity of a new physical activity and sedentary behavior (PA/SB) identity scale using 2 independent samples of US adults.

Methods

In study 1, participants answered 21 candidate items for the PA/SB identity scale and completed the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Study 2 participants completed the same PA/SB identity items twice over a 1-week interval and completed the IPAQ-SF at the end. We performed factor analyses to evaluate the structure of the PA/SB identity scale, evaluated convergent validity and test-retest reliability (in study 2) of the final scale scores, and examined their discriminant validity using tests for differences in dependent correlations.

Results

The final PA/SB identity measure was comprised of 3 scales: physical activity role identity (F1), physical activity belief (F2), and sedentary behavior role identity (F3). The scales had high test-retest reliability (Pearson correlation coefficient: F1, r=0.87; F2, r=0.75; F3, r=0.84; intraclass correlation coefficient [ICC]: F1: ICC=0.85; F2: ICC=0.75; F3: ICC=0.84). F1 and F2 were positively correlated with each other (study 1, r=0.76; study 2, r=0.69), while both were negatively correlated with F3 (Pearson correlation coefficient between F1 and F3: r=–0.58 for study 1 and r=–0.73 for study 2; F2 and F3: r=–0.46 for studies 1 and 2). Data from both studies also demonstrated adequate discriminant validity of the scale developed. Significantly larger correlations with time in vigorous and moderate activities and time walking and sitting assessed by IPAQ-SF with F1, compared with F2, were observed. Significantly larger correlations with time in vigorous and moderate activities with F1, compared with F3, were also observed. Similarly, a larger correlation with time in vigorous activities and a smaller correlation with time walking were observed with F2, compared with F3.

Conclusions

This study provided initial empirical evidence from 2 independent studies on the reliability and validity of the PA/SB identity scales for adults.
Reconstrucción geológica del área del ecoparque El Arenal, Sierra Chichinautzin, México: Implicaciones sobre el origen de los depósitos de ceniza en el cerro Magdalena
Authors: Villalba Mantilla Natalia Isabel , Guilbaud Marie-Noëlle
Published: September 2024

El parque ecoturístico El Arenal, ubicado en la parte norte del campo monogenético de la Sierra Chichinautzin, en el sur de la Ciudad de México, es conocido por su ceniza volcánica con forma de duna depositada sobre el cerro Magdalena. Antes de este trabajo, no habia estudios detallados sobre este depósito, su fuente ni procesos de formación, y la historia geológica del área aledaña era poco conocida. Este trabajo se centra caracterizar la ceniza del Arenal así como los productos del área aledaña, para determinar el origen de esta y su proceso de sedimentación. Esto se realizó mediante análisis de datos remotos (Lidar y fotografías aéreas) y trabajos de campo y de laboratorio (fechamientos, granulometría, componentes, petrografía, química total y mineral). El depósito del Arenal está conformado por una ceniza tamaño medio bien seleccionada, de composición andesítica, que contiene varios componentes juveniles y líticos. En el área aledaña identificamos cinco diferentes unidades volcánicas que se succeden estratigráficamente, desde abajo hasta arriba, de la siguiente manera: 1) el domo dacítico del cerro Magdalena, 2) el cono de escoria del Volcán Yololica y sus depósitos de caída y flujos de lava basálticos (fechado en 22,000 años antes del presente), 3) los depósitos de caída andesíticos de la Pómez Tutti Frutti del estravolcán Popocatépetl, 4) los depósitos de caída, principalmente andesíticos, del Volcán Pelado, y 5) las lavas basálticas del Volcán Xitle. Concluimos que el Arenal se formó poco después de la erupción del Volcán Pelado, por la removilización eólica de sus depósitos de caída y de la pómez Tutti Frutti subyacente, mediante tormentas de ceniza, la mezcla de estos productos se depositó como una duna sotavento en la ladera del cerro Magdalena, y fue recubierta posteriormente por las lavas del Volcán Xitle.
Nest architecture of stingless bee, Tetragonula iridipennis Smith from Assam, North East India
Authors:   Polytechnic of Agriculture, Acharya N.G. Ranga Agricultural University, Garikapadu-521 175, India, Saranya P.S. , Borkataki S. ,   Department of Entomology, Assam Agricultural University, Jorhat-785 013, India, Sen S. ,   Department of Agril. Entomology, Bidhan Chandra Krishi Viswavidyalaya, Nadia-741 252, India, Deka M.K. ,   Department of Entomology, Assam Agricultural University, Jorhat-785 013, India, Devee A. ,   Department of Entomology, Assam Agricultural University, Jorhat-785 013, India, Das K. ,   Department of Crop Physiology, Assam Agricultural University, Jorhat-785 013, India, Bhattacharyya B. ,   Department of Entomology, Assam Agricultural University, Jorhat-785 013, India, Taye R.R. ,   AAU-Zonal Research Station, Karimganj-788 710, India, Reddy M.D. ,   M.S. Swaminathan School of Agriculture, Centurion University of Technology and Management, Paralakhemundi-761 211, India, Nanda S.P. ,   School of Applied Sciences, Centurion University of Technology and Management, Paralakhemundi-761 211, India
Published: September 2024

Aim: To study the nest architecture and nest components of Tetragonula iridipennis. Methodology: The nest architecture was observed for better understanding under AICRP on Honey Bees and Pollinators during 2021-22. The cumulative effects of seasonal variations on development of individual brood, pollen and honey areas were determined by One-way ANOVA. Results: The length and width of entrance tube varied from 25 to 30 mm and 15 to 20 mm. The average length and breadth of the brood cell was 3.75 mm and 2.55 mm, pollen pot was 7.14 mm and 6.68 mm and honey pots was 7.88±0.03 mm 6.56±0.04 mm, respectively. The results revealed that the highest total brood area (1386.47±42.63 cm sq.) was recorded in 15504 cc hive. Based on the observations, the hives 15504 cc and 14364 cc were considered to have the stronger colonies due to their larger brood areas in comparison to 6664 cc hive. Interpretation: Despite of stingless bees' significance, comprehensive studies particularly in Assam, are lacking. To address this gap, the nest architecture, components, and brood rearing activities of T. iridipennis was studied. Key words: Brood rearing activities, Nest architecture, Nest components, Pollinators, Tetragonula iridipennis