bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic identification of submersed dodder (Cuscuta: Convolvulaceae) in Texas, U.S.A.
Authors: Williams Casey R. , Tippery Nicholas P. , Les Donald H.
Published: December 2022

Cuscuta plants that were observed growing entirely submersed and parasitizing the aquatic macrophyte Hygrophila polysperma in the San Marcos and Comal Rivers in Texas, are identified genetically as C. obtusiflora. This note documents the first molecular identification of any Cuscuta species naturally growing underwater or parasitizing a submersed aquatic plant.
Annual Review of Phytopathology, Volume 59
Authors: Lipscomb Barney
Published: December 2022

The Annual Review of Phytopathology, in publication since 1963, covers significant developments in the field of plant pathology, including plant disease diagnosis, pathogens, host-pathogen interactions, epidemiology and ecology, breeding for resistance and plant disease management, and includes a special section on the development of concepts. Volume 59 has 18 papers.
Annual Review of Environment and Resources, Volume 46
Authors: Lipscomb Barney
Published: December 2022

The Annual Review of Environment and Resources, in publication since 1976, provides authoritative reviews of significant topics within environmental science and engineering, including ecology and conservation science, water and energy resources, atmosphere, oceans, climate change, agriculture and living resources, and human dimensions of resource use and global change.  Volume 46 (2021) has 25 papers.
Systematics, Evolution, and Ecology of Melastomataceae
Authors: Lipscomb Barney
Published: December 2022

Systematics, Evolution, and Ecology of Melastomataceae (2022), presents a synthesis of critical new information for the Melastomataceae, one of the ten richest families among flowering plants with over 5,800 species that has its diversity highly concentrated in the tropics tropical or subtropical areas. It describes the family’s global diversity and distribution and summarizes recent advances in systematics, evolution, biogeography, reproductive biology and ecology.
Index to Journal of the Botanical Research Institute of Texas, Volume 16, 2022
Authors: Lipscomb Barney
Published: December 2022

Index to Journal of the Botanical Research Institute of Texas, Volume 16, 2022, includes titles, authors, botanical names and subject index, and new names and new combinations.
Primary Prostate Cell Culture from prostatectomies v1
Authors: Jung Mira
Published: December 2022

Based on the tissue collection protocol under the Georgetown University’s Institutional Review Board approval, fresh clinical specimens were transferred from the operating room to surgical pathology, processed and examined by the pathologist for areas of tumor or normal (non-tumor) regions for biopsies. The specimens were placed on ice and transferred to the laboratory for processing, outgrowth and expansion. To generate primary cell cultures, the minced tissues were cultured in collagen-coated cell culture dishes with keratinocyte serum-free medium (K-SFM) supplemented with human recombinant epidermal growth factor (rEGF) and bovine pituitary extract (BPE) at the time of use. Tissue explants were grown to confluence, and aliquots of the primary cultures were frozen and stored in liquid nitrogen. To further expand primary cells, irradiated 3T3 J-2 cells derived from mouse embryonic fibroblast cells were used as feeder cells for growing epithelial cells. J2 cells were cultured in complete DMEM, 10% heat inactivated FBS and 1 % Pen Strep. The complete DMEM and Ham’s F-12 nutrient mix (25%) supplemented with hydrocortisone, epidermal growth factor, bovine insulin, cholera toxin, amphotericin B, gentamicin, and Rock Inhibitor (Y-27632) was used to grow primary epithelial cells with irradiated J2 cells with 30 Gy of gamma radiation.
The blueprint and materials for building an imaging platform v1
Authors: Chan Wei-Ping
Published: December 2022

Details could be found in the Supplementary Information of "A high-throughput multispectral imaging system for museum specimens"
Digital Versus Printed Multilingual Dictionary: Developing Young Learners' English Literacy
Authors: Ratminingsih Ni Made , Agustini Ketut , Budasi I Gede , Adnyani Luh Putu Sri , Ana I Ketut Trika Adi
Published: December 2022

This study aimed to compare the effect of digital and printed multilingual dictionaries on young learners' literacy. Besides, it also explored the students’ responses on the implementation of those dictionaries. To achieve the study's objectives, the researchers followed a sequential mixed method that started with the quantitative method and followed with the qualitative method. There were two classes involved in this study. Those two classes were selected using the matching technique. One class was treated as an experimental class, while the other was the control class. To collect the study's data, the researchers used a literacy test for the quantitative method and a questionnaire, and an interview guide for the qualitative method. The quantitative data were analyzed statistically using an independent t-test, while the qualitative data were analyzed using an interactive data analysis model. This study statistically confirmed that the digital multilingual dictionary was better than the printed dictionary. The results of the questionnaire and interview supported the finding that young learners had positive responses toward the use of both dictionary, however they also affirmed that the digital dictionary was more interesting and could help them more to study English vocabulary with the pronunciations.
Memes to Foster L2 Speaking and Writing
Authors: M Senguttuvan , S Gandhimathi S N , R Vijayalakshmi , R Calaivanane , Baisel Anu , S Subha , M Vijayakumar
Published: December 2022

Memes are the new social media language and they increasingly exercise their potency of effecting intense discourses among younger audience. In this dimension, they are seen as interesting resources of communication that can promote L2 learning. English Language Acquisition (ELA) has always been a challenge for vernacular-medium Indian students. The study took 177 student participants (with vernacular-medium background) pursuing UG programmes that had English as the medium of instruction. The research objective was to bring out the significance of employing memes to bridge the gap the learners find on their way to manage all their courses in English language. This empirical, questionnaire-based-survey addressed the research objectives: Explication of the notion of employing memes as informal materials; Demonstration of the use of memes for the development of L2 competencies; and Analysis of Learners’ perceptions/attitudes towards the use of memes in Second Language Acquisition (SLA). It revealed the areas that had seen significant improvement in speaking, writing, grammar, and vocabulary.
Linguistic Landscape in Najran: A Sociolinguistic Approach
Authors: Al-Athwary Anwar A. H.
Published: December 2022

This study attempts to investigate the linguistic landscape (LL) of the city of Najran, a city located in the southern region of Saudi Arabia. To achieve this objective, a sample of more than 450 signs is examined. The study focuses on the shop signs which are usually known as bottom-up signs (Ben-Rafael et al., 2006; Ben-Rafael, 2009). The analysis reveals that Najran’s LL is more multilingual than expected. In addition to Arabic and English, it displays some foreign expatriate languages such as Malayalam, Bengali, Tamil, and Hindi. Arabic appears to be the most dominant language followed by English, with the former having both informational and symbolic (cultural) roles while the latter has a commercial and advertising function through which shop owners want to appear more fashionable and more prestigious. The use of the expatriate languages of the Indian subcontinent serves mainly as a psychological tendency to compensate for the feeling of being homesick, and partially performs an informational function directed to the expatriate group.
Rethinking Film Adaptation Through Directors’ Discourse and Auteur Theory: Approaching Dan Brown’s The Da Vinci Code
Authors: Theodar M Caleb , P Saranya
Published: December 2022

This article examines the apropos of Dan Brown’s novel - adaptation, The Da Vinci Code, to the director’s discourses around the film adaptation of a literary work. Ron Howard’s stance as an auteur is assessed to gauge him as an illustrator of American filmmaking in terms of auteur discourses and formulate that his work disavows significant portions of the Catholic conspiracies, sidestepping the subject of authenticity, which is at the forefront of contemporary literature adaptation discourses. Despite appearing to be more ‘authentic,’ the film falls short of the fidelity to source material that was an avowedly auteurist vision and is shown to have issues with authorship. This paper proposes the contemporary auteur influence, examining how the concept of directors’ discourse functions in the Hollywood film industry and the director’s stature as an auteur and the works’ creative style in literary, screen adaptation and movie translation.
Dayak’s Sociocultural Situation Through Locality in Lumholtz’s Through Central Borneo Travel Writing
Authors: Arifin M. Bahri , Arafah Burhanuddin , Kuncara Singgih Daru
Published: December 2022

This research is intended to discuss the portrayal of the sociocultural situation of Dayak as indigenous people in Borneo through the locality in Through Central Borneo travel writing. This research also discovered the self and the other concept through the author’s interaction with people in visited places. The focus of this research is on the passage of the Mahakam River only. The locality studied in this research is bound to a specific cultural context in the East Kalimantan, particularly in the Mahakam River area. This research fits descriptive qualitative research. The data are taken from the travel writing only, in the form of words, phrases, and sentences that meet the aim of this research. The outcomes show that the locality defines the sociocultural situation of Dayak. It can be seen through the place, social organization, habit, object, convention, ecology, character, and belief. Many layers of the author’s choices in describing the sociocultural situation in the travel writing bring the issues of revealing the self and representing the other in the concept of ‘different’ between the author and the visited people.
Characteristics of injuries in cyclists injured when other vehicles collide with the side of the body of moving bicycles
Authors: Indiaminov Sayit I. , Abdumuminov Khasan N. , Boymanov Farxod Kh.
Published: December 2022

BACKGROUND: Bicycle injuries, as a separate type of traffic accidents, require forensic medical examinations to establish the mechanism, duration, and severity of injuries. Forensic medical aspects of cycling injuries are insufficiently covered in the literature.
AIM: To study the nature and features of the injury formation in cyclists who sustained injured when other vehicles hit the side of the moving bicycle.
MATERIALS AND METHODS: The results of forensic medical examinations of 51 cyclists who died when the moving bicycles collided with the side of vehicles.
RESULTS: The most frequently observed injuries in cyclists are traumatic brain injury (21.56%) and combined injuries, namely, head and chest (15.68%), lower extremities with trauma to the head, and chest (11.76%). Nearly all deceased cyclists sustained damage to the head (96.0%), which was characterized by the formation of a severe contusion of the brain with fractures of the parietotemporal and occipital bones. Damage to the chest and chest cavity organ was also observed frequently (50.69%). Rib fractures were noted in 74.2% of cases. Injuries to the abdominal organs were detected in 20.15% of the cases, such as liver rupture and hemorrhage in the ligaments of organs. Diaphyseal comminuted fractures of the bones of the lower leg and femur were also observed.
CONCLUSION: The most common types of injuries in deceased cyclists in a side collision of other vehicles with a moving bicycle are traumatic brain injury and combined injuries of the head, chest, and fractures of the bones of the lower extremities in combination with a head and chest injury. Damage to the head was characterized by the formation of linear, depressed, and comminuted fractures of the parietaltemporal and occipital bones. Damage to the chest was characterized by fractures of the upper ribs and bruises of the lungs. Damage to the skin, resembling a picture of a road rash, was noted on the anterolateral body parts.
Rotational Components of Normal Modes Measured at a Natural Sandstone Tower (Kane Springs Canyon, Utah, U.S.A.)
Authors: Dzubay Alex , Moore Jeffrey R. , Finnegan Riley , Jensen Erin K. , Geimer Paul R. , Koper Keith D.
Published: December 2022

Modal analysis of freestanding rock formations is crucial for evaluating their vibrational response to external stimuli, aiding accurate assessment of associated geohazards. Whereas conventional seismometers can be used to measure the translational components of normal modes, recent advances in rotational seismometer technology now allow direct measurement of the rotational components. We deployed a portable, three-component rotational seismometer for a short-duration experiment on a 36 m high sandstone tower located near Moab, Utah, in addition to conducting modal analysis using conventional seismic data and numerical modeling. Spectral analysis of rotation rate data resolved the first three natural frequencies of the tower (2.1, 3.1, and 5.9 Hz), and polarization analysis revealed the orientations of the rotation axes. Modal rotations were the strongest for the first two eigenmodes, which are mutually perpendicular, full-height bending modes with horizontal axes of rotation. The third mode is torsional with rotation about a subvertical axis. Measured natural frequencies and the orientations of displacements and rotation axes match our numerical models closely for these first three modes. In situ measurements of modal rotations are valuable at remote field sites with limited access, and contribute to an improved understanding of modal deformation, material properties, and landform response to vibration stimuli.
Predicción de mortalidad en sepsis: Aplicación de qSOFA en pacientes atendidos en una institución de Barranquilla
Authors: Quintero Osorio María Fernanda , Escorcia Buendía María Carolina , Rojano Rada Jairo , Fernández Chica Dinno
Published: December 2022

Objetivo: Evaluar la predicción de mortalidad mediante la escala qSOFA y otros indicadores clínicos en pacientes con sepsis, en el servicio de terapia intensiva en una institución de salud de la red pública de la Ciudad de Barranquilla, entre Julio de 2020 a febrero de 2021. Métodos: Se realizó un estudio analítico, longitudinal, prospectivo. Con la información obtenida, se realizó la base de datos en Excel, y un análisis univariado y multivariado para describir el mejor predictor de mortalidad en sepsis. Resultados De 101 casos, el 82% (n=83) tenían shock séptico, mayor presentación en el sexo masculino con 61% (n=64), con mayor frecuencia de estrato socioeconómico 1, la mayoría fueron sepsis adquirida en comunidad 81% (n=85), con un índice de comorbilidad de Charlson de 3,4 ± 3,0. Las mediciones seriadas del lactato y de la PCR, no tuvieron relación estadísticamente significativa con mortalidad. El valor de q-SOFA presentó una asociación estadísticamente significativa con la mortalidad (p < 0,05), valores de q-SOFA elevados tienen el doble de riesgo de muerte (OR = 2,16; IC 95% = 1,08 – 4,33). Sensibilidad de 68,6% y especificidad de 48,4%, VPP de 76% y VPN de 34,37%. Conclusión:  La escala qSOFA se encontró como el mejor predictor de mortalidad en sepsis comparado con SIRS, SOFA, PCR y Lactato.
Resiliencia comunitaria en tiempos de educación virtual pandemia Covid-19, el caso de las radios comunitarias
Authors: Fernández Chica Dinno
Published: December 2022

La crisis suscitada por la pandemia de COVID-19 dejó al descubierto vulnerabilidades y desigualdades sociales históricas, siendo los grupos más desfavorecidos y marginados bien por su posición de clase, raza o genero los más perjudicados no solo a nivel sanitario sino también en materia social, económica y por supuesto, educativa. La pandemia expuso una serie de dificultades relacionadas con la educación virtual en el país, principalmente en los colegios y universidades públicas, la poca alfabetización digital junto con los bajos índices de conectividad a lo largo del país configuró un reto no solo para los gobiernos, sino también para las instituciones educativas y las familias con el fin de que los procesos educativos no se detuvieran.
Aportes para la Promoción de mayor Transparencia en los Estudios Psicométricos
Authors: Flores Kanter Pablo Ezequiel , Mosquera Mariano
Published: December 2022

Estamos en presencia de un gran momento para el avance de la ciencia psicológica. Disponemos actualmente de una amplia gama de recursos y fuentes para adherir a buenas prácticas de investigación, que permitan desarrollar una disciplina cada vez más confiable, válida y reproducible. Dentro de los comportamientos responsables en investigación, es indispensable fomentar la adhesión a prácticas de transparencia y ciencia abierta. Y si bien actualmente es difícil pensar que algún investigador o investigadora no acuerde con estos principios y prácticas, su implementación no es aún generalizada o extendida, ni en todas las disciplinas y subdisciplinas, ni por igual en todos los países. Aquí nos interesa centrarnos en las prácticas de medición, es decir, en el campo de la psicometría. Consideramos que las prácticas transparentes y de ciencia abierta son una solución viable y fundamental para contrarrestar las conductas cuestionables en investigación y, especialmente, aquellas referidas a las prácticas cuestionables en medición. Centrarse en estas prácticas psicométricas o vinculadas a la medición es fundamental, dado que de ellas depende la validez más general de nuestros hallazgos científicos. El fin último de este trabajo es ofrecer una serie de recursos que faciliten la divulgación y adhesión de estos comportamientos responsables en investigación entre los investigadores de Latinoamérica.
Cuestionario de Preocupación de Pensilvania (PSWQ 11): Evidencias Psicométricas en una muestra de Adultos de Lima Metropolitana
Authors: Carbonell-Bártoli Enzo Lucciano , Tume-Zapata Valery Nicolh
Published: December 2022

El Cuestionario de preocupación de Pensilvania (PSWQ 11) es una medida que evalúa la tendencia a experimentar la experiencia de preocupación. El presente estudio tuvo por objetivo analizar las propiedades psicométricas del PSWQ 11 en población adulta de Lima, Perú. La muestra constó de 535 adultos con edades entre 18 y 55 años (M= 25.13, DE= 7.03). Se analizaron los estadísticos descriptivos encontrándose distribuciones normales en todos los ítems, así como adecuadas correlaciones ítem-test corregidas. A través del análisis de la estructura interna, el instrumento demostró obtener índices de ajuste adecuados para un modelo con covarianza de ítems (χ²/gl= 4.32; CFI= .99; TLI= .99; RMSEA= .08; SRMR= .03; WRMR= .95). Asimismo, mediante el análisis de las relaciones con otras variables, se demostró la validez convergente y discriminante del PSWQ 11 relacionándolo con el PANAS. También, se obtuvo un coeficiente alfa de .94, encontrando que la medida es confiable. Por último, se demostró la invarianza factorial del instrumento por sexo y por edad, por lo que no presenta diferencias en la evaluación de la preocupación en estos grupos.
Miedo al coronavirus y depresión en estudiantes de psicología de Ica
Authors: Chacaltana-Hernández Katia Marilyn , Bontempo Lozano Elsa María , Varela Guevara Silvana Graciela
Published: December 2022

El estudio tiene como objetivo establecer los niveles y la relación que existe entre el miedo al coronavirus y depresión en estudiantes de psicología de Ica., es de tipo no experimental, descriptiva correlacional, participaron 157 estudiantes de la facultad de Psicología de Ica, se utilizaron los siguientes instrumentos: Escala de miedo al coronavirus (Sars-cov2)-Versión peruana y Escala Psicopatología Depresiva (EDP). Los resultados encontrados evidencian un 78. 4 % de Miedo a contraer el Covid-19 y un 20.4 % presentan síntomas depresivos, así mismo, se halló que existe relación directa y altamente significativa entre ambas variables de estudio, no se encontraron diferencias significativas según edad y sexo a excepción del ciclo académico.
Experiencias subjetivas sobre las clases virtuales en universitarios peruanos en tiempos de COVID 19
Authors: Sulca Chumbiauca Kiara , Angulo García Lilia Elena , Campo Pujay Esvila , Cano Rivero Cristina Angélica , Carranza Calvo Gissela Karina , Castillo Espinoza Rosa Nilda , Castro Solís Marleny , Cueva Colan María Fernanda , Guidotti Joscely Esteban , Nima Urdanivia Silvia Mercedes , Ramírez Azañedo Ingrid Dallana , Ríos Polo Pamela Magaly , Rivera Silva Lourdes , Velazco Yachachín Kerly Nanette
Published: December 2022

La presente investigación es de corte cualitativo que tiene como objetivo conocer la percepción sobre la experiencia de recibir clases virtuales en universitarios peruanos, se realizó entrevistas semi-estructuradas a un grupo de jóvenes universitarios, cuyas edades oscilan entre los años 18 a 40 años de edad de diversos niveles económicos y culturales.
The Clinical Spectrum of Mutations in CAP2
Authors: Levitas Aviva , Krymko Hanna , Slanovic Leonel , Parvari Ruti
Published: December 2022

Background: Dilated cardiomyopathy leads to contractile dysfunction, progressive heart failure, and excessive risk of sudden cardiac death. We reported a homozygous damaging variation in CAP2 causing dilated cardiomyopathy and supraventricular tachycardia in two cousins of one family. Additional homozygous mutations in CAP2 with clinical presentations were reported.  Aim: To present the different CAP2 mutations described in patients of various populations with a spectrum of clinical descriptions and possibly correlate the mutations to the clinical findings. This is important for the diagnosing and prognosis of patients with mutations in this gene. Methods: Clinical evaluation of an additional patient of the family we previously reported. Literature searches of clinical studies of patients affected by mutations in CAP2, animal models for the gene, and the role of CAP2 in the assembly of actin in the thin filaments of the sarcomere. Results: All patients had dilated cardiomyopathy necessitating heart transplants at a very young age. Two patients with one loss of function mutation presented additionally with structural heart abnormalities. Another loss of function mutation in one patient associated with nemaline myopathy, mild hypotonia, atrophic, and widened scarring. One report did not detail the patient's mutation and presented tricuspid and pulmonary atresia. Animal models of mice and sheep had additional defects not reported in human patients. The pathology is caused by the loss of the function of CAP2 in actin polymerization and in the “α-actin switch” occurring during differentiation and required for the sarcomere structure and function. Conclusions: The homozygous mutations in CAP2 cause severe Dilated cardiomyopathy. Additional phenotypes may not be seen in all individuals, and the severity of the mutation and disease do not correlate.
Nurse-led HIV Preexposure Prophylaxis in the United States: Landscape, Opportunities and Challenges
Authors: Abbas Ume , Dickson Aimee , Gilmore D. , Bamberger David , Scott Hyman
Published: December 2022

Preexposure prophylaxis is a powerful biomedical intervention for prevention of human immunodeficiency virus. However, its implementation has been slow and uneven in the United States. Research into innovative agents, formulations and implementation, for preexposure prophylaxis, is ongoing, and a number of new and improved methods of delivery have been developed. However, the delivery of preexposure prophylaxis primarily by nurses, has not received much attention. We overview the global evidence and programs for nurse-led preexposure prophylaxis, and propose this as a feasible and promising implementation strategy for the United States.
Neuroimaging Findings in Symptomatic Hypertensive Encephalopathy
Authors: Bertoni Miguel , Webb Thomas , Balogun Ibrahim , Ellul Gordon , Dalvi Amod , Baht Hardeep , Thomas George , Abubakar Saidu , Gunathilaghan Gunaratanam , Abdallah Rami , Omojowolo Olobunmi , Hargroves David
Published: December 2022

To assess the relevance clinicians and radiologists assign to making hypertension (HTN) explicit in acutely symptomatic subjects admitted for either stroke, confusion or cognitive deficit, a revision was carried out of cases discussed in our institution in the last eleven years, at either the Neuroradiology-Stroke or the Neuropsychiatry multidisciplinary meetings (MDTs). Consistency of the provided clinical information and radiological findings concerning HTN were checked in 11810 subjects (Group 1), since both influence neuroimaging interpretation, diagnosis and management. Similar information was collected in a subgroup of 25 subjects (Group 2), with signs of stroke included in Group 1 in whom there was pre-existent history of severe HTN, who were evaluated with multimodality neuroimaging in 48 hours from admission and who had improved clinically in 72 hours. The word “hypertension” included in the initial neuroimaging request, blood pressure (BP) levels on admission, radiology reports describing intra axial bleed, mentioning “hypertensive encephalopathy”, “chronic hypertensive encephalopathy”, “hypertensive microbleeds”, “amyloid microbleeds”, features and quantification of cerebral small vessel disease (CSVD), a non-specific pattern of cortical atrophy, dolicoarteriopathy, presence and degree of carotid or vertebrobasilar stenosis were tabled. Electronic records of blood pressure (BP) were available in 10003/11810 cases and in written notes in 1807/11810; 1582/11810 were not hypertensive and 8421/11810 hypertensive. Imaging requests did explicitly include the word “hypertension” in 1184/11810. Radiology reported acute intracranial bleed on admission in 1516/11810, hypertensive encephalopathy in 248/11810, chronic hypertensive encephalopathy in 148/11810, hypertensive-type microbleeds in 295/11810, amyloid-type microbleeds in 390/11810, SVD features without quantification in 1554/11810, SVD 1/3 in 577/11810, SVD 2/3 in 1402/11810, SVD 3/3 in 776/11810, non-specific cerebral atrophy in 800/11810, vessel tortuosity in 128/11810 and significant carotid or vertebrobasilar stenosis in 1292/11810 of cases. On neuroimaging revision, one or more HTN features were found in 10311/11810 cases. In group 2 mean systolic BP on admission was 193mmHg, diastolic 104mmHg, age 55 years, 15/25 had PRES, 7/25 acute on chronic hypertensive encephalopathy, 2/25 CAA and 1/25 normotensive PRES. HTN findings were reported in 22/25 cases. Results suggest an initial underestimation of HTN by both referrers and radiologists in acutely symptomatic subjects, later identified and characterised when reviewed and discussed at MDTs.
Interaction of Human Immunodeficiency Virus-1 Vpr and Glucocorticoid Receptor using Bimolecular Fluorescence Complementation (BiFC) analysis
Authors: Li Yaming , Iyer Priyadarshini , Hadi Kevin , Ayyavoo Velpandi
Published: December 2022

Human Immunodeficiency Virus-1 Vpr, a nonstructural protein incorporated into virus particles, possesses several features contributing to virus replication and cytopathic effects. Vpr induced effects are mediated through its interactions with viral and/or host cellular proteins, in particular, the host protein, Glucocorticoid Receptor (GR). Though GR is known to increase Vpr-mediated HIV-1 transactivation, Vpr-GR interaction and its subcellular localization have not been studied in cells. Towards this, we evaluated Vpr interaction with GR in cells using Bimolecular Fluorescence Complementation analysis by generating chimeric Vpr or GR with the N- and C-terminal fragments of Venus protein. Our results showed that interaction between Vpr and GR requires certain Vpr and GR domains. Specifically, leucine residues in the third helical domain of Vpr and N-terminal domain of GR is involved in Vpr-GR interaction. Altering these residues not only interferes with Vpr-GR interaction, but also prevents translocation of this complex into the nucleus. Further, utilizing a mutant Vpr unable to oligomerize, we show that Vpr oligomerization is essential for optimal interaction with GR. In conclusion, by taking advantage of BiFC system, specific residues in Vpr have been found to be associated with binding GR and the subcellular distribution of Vpr-GR complex.
Socio-Demographic Predictors of Depression During the First COVID-19 Lockdown
Authors: Lubin Robert , Voldman Bruna , Peller Hallie , Green Heather
Published: December 2022

Depression has been associated with poor health outcomes. This study sought to answer three research questions. Firstly, are there significant differences in the frequency of participants who screen positive for anxiety and depression in the population segregated by sociodemographic factors such as gender, age, living alone, and socioeconomic status (SES)? Second, what sociodemographic factors were predictors of anxiety and depression symptoms? The third research question, what extent does loneliness predict anxiety and depression symptoms when controlling for demographic measures. With regards to depression, the results of the analysis supported our hypothesis that low-income participants were more likely to screen positive for depression compared to higher income participants.
Evaluation of the Available Animal Models for Bartonellosis
Authors: Bullard Rebekah , Olsen Emily , Cheslock Mercedes , Embers Monica
Published: December 2022

The diseases caused by the Bartonella genus of bacteria are clinically diverse, difficult to reliably diagnose, and can be challenging to cure. The study of Bartonelloses has been hampered by the lack of a suitable animal model. Preclinical studies for novel therapeutics and a competent host for vector transmission studies are needed to fill critical knowledge gaps. The studies included here are a representation of in vivo Bartonella research and the challenges this line of research faces. This review examines the current state of available animal models by assessing the success of various model species and strains in Bartonella infection. With a focus on the strengths and weaknesses of current animal models, the importance of these models for improvement of human health and veterinary care is emphasized.
Tolerability and Stability of Mask Fixation in Gamma Knife Stereotactic Radiosurgery: Predictors of Treatment Interruptions
Authors: Yang F , Bowden G , Patel S , Ghosh S , Yun J , Aronyk K , Amanie J , Warkentin B , Larocque M , Heikal A , Rowe LS , Wheatley BM , Fairchild A
Published: December 2022

Background. Frameless fixation with a thermoplastic mask is an alternative to traditional frame-based immobilization for Gamma-Knife stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT). However, interruptions during beam-on time can significantly prolong treatment delivery, impacting patient experience and unit workflow. Aim. We investigated clinical and technical predictors of treatment interruptions, and the phases of treatment during which interruptions are most likely to occur. Methods. Patients undergoing frameless Gamma Knife SRS or FSRT in 2020 were retrospectively reviewed. Clinical parameters were extracted from electronic medical records. Dosimetric and treatment interruption data were obtained from Gamma Knife treatment reports. Univariate and multivariate analyses analyzed technical and clinical predictors of treatment interruptions. Results. Our cohort included 84 patients receiving 141 fractions encompassing 255 lesions. 49/84 (58.3%) were female, 79/84 (94.0%) had brain metastases, 49/84 (58.3%) were taking dexamethasone and 30/84 (35.7%) used analgesics. 89/106 (84.0%) courses were single fractions. Mean planned beam-on time was 37.1 minutes (range 7.1-118.8 min) versus a total bed time of 64.9 minutes (range 15-252min) per fraction. 64.5% (91/141) of fractions were interrupted at least once; 12/141 fractions were paused 20 times or more, with a maximum 54 pauses. The mean number of pauses per quartile decreased the further the patient proceeded in beam-on time, and patients receiving first lifetime cranial radiation paused more often than during subsequent fractions. At least one pause occurred in 100% of fractions with a planned beam-on time exceeding 60 minutes. Planned beam-on time, number of gating events and high-definition motion management alarms significantly correlated with total number of pauses on multivariate analysis (all p<0.0001); these three factors, along with prep time and number of operator-initiated pauses, predicted total time on the Gamma Knife couch (all p<0.0001). Clinical factors, medication use, and prior SRS/FSRT were not predictive of pauses. Conclusions. Planned beam-on time, number of gating events and high-definition motion management alarms significantly predicted likelihood of interruptions during frameless Gamma Knife SRS/FSRT. These factors should be considered in selection of immobilization method, especially if exceeding 60 minutes.
Heart Failure Due to Idiopathic Hypereosinophilic Syndrome in Pregnancy: A Case Report and Review of the Literature
Authors: Mert Ali , Aydin Selda
Published: December 2022

Heart Failure Due to Idiopathic Hypereosinophilic Syndrome in Pregnancy: A Case Report and Review of the Literature
Characteristics and predictors of high acuity pediatric patients presenting to a regional community healthcare system who require transfer to a tertiary pediatric center.
Authors: Valani Rahim , Khalid Maroof , Snyder Hannah , Sharma Tanmay , Upadhye Suneel , Brown Shira
Published: December 2022

Purpose: To identify the characteristics at triage of high acuity pediatric patients who presented to community emergency departments and determine predictors for those who require transfer to a tertiary care pediatric center. Patients and methods: We conducted a retrospective study of all pediatric Canadian Triage and Acuity Scale (CTAS) I patients presenting to five semirural hospital sites from January to December 2018. Univariate tests were used to identify significant predictors for transfer based on age, gender, Pediatric Early Warning Score (PEWS) score and presenting complaint. A multivariate model was developed based on backward selection from the significant factors from the univariate analysis to identify predictors for transfer. Results: There were 1,137 subjects with an average age of 5.08 years (SD: 5.03) of whom, 559 (49.2%) were males. Sixty patients (5.3%) were transferred to a tertiary care center (60.9% <4 years). A PEWS score ≥3 (OR 3.005, 95% CI 1.623–5,563), presenting with trauma (OR 6.617, 95% CI 2.820–15-531), mental health issues (OR 5.131, 95% CI 1.444–18.232), or neurological issue (OR 3.057, 95% CI 1.355–6.896) were associated with transfer. Patients with fever (OR 0.113, 95% CI 0.031–0.407) and respiratory symptoms (OR 0.345, 95% CI 0.142–0.840) were less likely to be transferred. Conclusion: Predictors of transfer from a community hospital to a pediatric tertiary care center were a PEWS score ≥3, trauma patients, those presenting with mental health issues, and patients with neurological symptoms. Early recognition can facilitate quicker transfer of these high acuity patients requiring tertiary care management.
Growth Factors and Effects of Palifermin in Management of Cancer Therapy Induced Oral Mucositis
Authors: Shrivastava Noopur
Published: December 2022

Amongst the various hazards of chemotherapeutic drugs and radiation in cancer patients, oral mucositis is the most commonly encountered and troublesome complication so far. It can be a cause for discontinuation of therapy and may add to the cost of treatment. In this article, pathogenesis of oral mucositis and role of recombinant human growth factors in management of it have been discussed, as we need to achieve a guideline for proper treatment of this painful side effect of cancer treatment. Palifermin, a keratinocyte growth factor has been shown to give promising results in cases of severe mucositis in hematopoetic stem cell transplant patients undergoing combined chemoradiotherapy. Other exogenous growth factors are also effective in the management of mucositis when administered topically or subcutaneously, but there is need for more number of studies with a large sample size for establishing a proper treatment plan which is cost effective as well as helpful in reducing patient’s discomfort.
Competitive Advantage between Malaysia and World Halal Producers of Ruminant Meat
Authors: Yusoff Hebat Hisham Mohd , Ismail Normaz Wana , Sidique Shaufique Fahmi Ahmad , Kamarulzaman Nitty Hirawaty
Published: December 2022

The gap created by the mismatch between high domestic demand and low domestic supply of halal meat has been filled by ruminant meat sourced from the international markets. However, the exporting countries are still limited due to stringent halal requirements. This study examined the competitive advantage of trading partners in the exportation of ruminant meat. Moreover, this study also identified factors underlying the import of ruminant meat and determined the comparative advantage of local production of ruminant meat. This study employed Vollrath indices through the utilization of relative export advantage, relative import advantage, and overall relative trade advantage. Analysis was conducted on 26 countries and 15 product codes of ruminant meat. The findings disclosed that the possession of competitive advantage did not exclusively belong to traditional sources but to other countries, particularly Pakistan and the Netherlands.
Praktik Akuntansi dalam Kacamata UMKM Binaan Rumah UMKM Kabupaten Barito Kuala
Authors: Hikmahwati Hikmahwati , Irwansyah Rusman
Published: December 2022

Penelitian ini bertujuan untuk mengeksplorasi bagaimanakah praktik akuntansi dan kendala-kendala apakah yang menghambat penerapan akuntansi bagi UMKM yang menjadi binaan Rumah UMKM Kabupaten Barito Kuala. Metode penelitian ini menggunakan pendekatan kualititatif deskriptif. Data dikumpulkan terutama melalui kuesioner google form dan wawancara secara langsung kepada 69 responden dipilih random sampling. Hasil penelitian menunjukkan bahwa sekitar 80% UMKM belum memiliki pemahaman terkait dengan akuntansi yang benar dan pentingnya akuntansi dalam pengelolaan sebuah usaha. Sebagian besar (51%) pelaku UMKM belum melakukan pecatatan atas transaksi penjualan, pembelian, persediaan barang, kas masuk, kas keluar dan pembayaran gaji dan transaksi lainnya. Sebagian besar (80%) pelaku UMKM yang melakukan pencatatan tidak menyimpan catatan secara permanen dan menggunakan sistem pencatatan single entry dan masih belum menerapkan pembukuan double entry. Sistem pencatatan 100% dilakukan secara manual. 30% pelaku UMKM enyusun laporan keuangan namun tidak disajikan secara lengkap dan 70% pelaku UMKM tidak membuat laporan keuangan. Alasan tidak melakukan pencatatan dan membuat laporan keuangan karena berbagai kendala yang menghambat.
Studi Eksperimental Pengaruh Posisi Menyudut Pendulum-Pelat Tembaga pada Getaran Pendulum Berperedam Arus Eddy
Authors: Noerpamoengkas Ardi , Ulum Miftahul
Published: December 2022

Redaman getaran dapat menggunakan mekanisme arus Eddy. Sistem utama diberi magnet dan didekatkan dengan logam konduktif sehingga timbul arus Eddy tersebut. Belum ada aplikasi jenis mekanisme ini untuk menghasilkan redaman non-linier. Pada penelitian ini, pendulum memiliki dua sisi lengan, lengan magnet dan lengan beban. Bidang gerak pendulum dan pelat tembaga membentuk sudut. Konfigurasi baru ini menghasilkan peredam non-linier dengan adanya sisi gerak simpangan pendulum yang dekat dan jauh dengan pelat. Jarak engsel pendulum dan pelat dibuat sama sehingga semakin kecil sudut semakin jauh sisi terdekat magnet-pelat. Respon getaran diperoleh dengan menggunakan software Tracker. Redaman yang dihasilkan tidak sama di dua sisi simpangan pendulum. Nilai redaman lebih besar di sisi simpangan yang dekat pelat. Semakin kecil sudut posisi bidang gerak pendulum bermagnet dan pelat logam semakin lama pendulum mencapai kondisi tunak dan semakin kecil nilai redaman rata-ratanya.
Kinerja Ruas Area Pasar Kembang Setelah Sistem Satu Arah di Kawasan Malioboro
Authors: Zulfikar Ariq Muhammad , Fauziah Miftahul
Published: December 2022

Kawasan Malioboro memiliki keramaian yang menimbulkan kemacetan pada Jalan Malioboro dan sekitarnya. Solusi mengatasi kemacetan adalah dengan menerapkan sistem satu arah untuk membatasi kendaraan menuju Jalan Malioboro. Salah satu ruas yang terkena dampak sistem satu arah pada Kawasan Malioboro adalah Jalan Pasar Kembang. Tujuan penelitian yaitu untuk mengetahui perbandingan kinerja ruas area Pasar Kembang sebelum dan sesudah penerapan sistem satu arah. Data primer diperoleh dari survei di lokasi penelitian dan data sekunder diperoleh volume lalu lintas Tahun 2019. Dari data tersebut dilakukan analisis MKJI 1997 dan pemodelan menggunakan software PTV VISSIM. Hasil menunjukkan perbandingan derajat kejenuhan pada ruas Jalan Pasar Kembang mengalami penurunan sebesar 56,06%, Jalan Malioboro turun sebesar 4,36%, Jalan Pajeksan turun 65,52%, sedangkan Jalan Gandekan naik 3,13%. Pada parameter kecepatan rerata didapatkan penurunan pada semua ruas yaitu Jalan Pasar Kembang turun 28,81%, Jalan Malioboro turun 30,02%, Jalan Pajeksan turun 12,56%, dan Jalan Gandakan mengalami penurunan 40,92%.
Distribution of mangrove health in the coastal area of Maros Regency in 2021 based on Sentinel-2 satellite imagery
Authors: Mappiasse Muh Faisal , Djafar Muliana , Asra Reza
Published: December 2022

Changes in the area of mangroves in the coastal area of Maros Regency have been degraded from year to year. Various problems that often occur cause a decrease in the distribution and quality of mangrove community health. This happens because there is still pollution and external disturbances which make the quality of the mangroves decrease. Therefore, it is important to know the condition of mangrove distribution to find the latest information and baseline data for area managers. The purpose of this study was to obtain information on the extent and type of mangrove health, as well as identify the types of mangrove damage in the coastal area of Maros Regency in 2021. This research method used (1) supervised classification, to obtain mangrove distribution, (2) analysis of mangrove health using the normalized difference algorithm vegetation Index, (3) map overlay, mangrove distribution map, administrative map, and mangrove health index map, (4) validation of mangrove health data through an assessment of mangrove conditions based on the distribution of observational plots in a proportionate stratified with random sampling. Mangrove areas are found in the coastal areas of Maros Regency and are scattered in Marusu District, Maros Baru District, Lau District, Bontoa District with an area of 131.87 ha, 95.59 ha, 85.37 ha, and 60.01 ha, respectively. Mangrove health is divided into 5 categories, namely excellent, good, normal, bad, and awful with an area of 100.73 ha, 240.43 ha, 1.99 ha, 9.5 ha, and 20.2 ha, respectively. While mangrove damage based on 30 sample points, 6 types of damage were identified, namely changed leaves, damaged shoot leaves and shoots, broken/dead branches, open wounds, resinosis, and broken stems with percentages of 29.91%, 19.63%, 17.76%, 16.82%, 12.15%, and 3.74% respectively.
Simultaneous Isomerization of Hexane and Heptane in the Presence of Pt-Containing Tungstated Zirconia Catalysts
Authors: Smolikov M. D. , Shkurenok V. A. , Bikmetova L. I. , Leontieva N. N. , Lavrenov A. V.
Published: December 2022

Isomerization of heptane and hexane and their mixtures in the presence of Pt/WO3-ZrO2 catalysts with the tungsten oxide content of 10–35 wt.% was studied. The best characteristics of isomerization of the С6–С7 alkanes mixture were observed on the catalysts with the WO3 content of 15–20 wt.%. According to ammonia thermodesorption data, the number of acid sites typically increases in this range of tungsten oxide content; according to IR spectroscopy of adsorbed CO, this occurs mostly with an increase in the number of Broensted acid sites.
Biodiesel Production from Waste Cooking Oil, using an Acid Modified Carbon Catalyst Derived from Cassava Peels
Authors: Garba Mustapha D. , Sunusi Abubakar M. , Hassan Sadi A. , Jackson S. David
Published: December 2022

An investigation was carried out to study the feasibility of using synthesized acid-bearing carbonaceous catalyst (SO3H–C and PO4H2–C) derived from cassava peel for biodiesel production from waste cooking oil (WCO). The catalyst activity was tested using an autoclave type reactor using three different oil to alcohol ratios (1 : 3, 1 : 5 and 1 : 7) at four different temperatures (50–80 °C) for 4 h. Two types of alcohol (i.e. methanol (CH3OH) and ethanol C2H5OH) were used to understand the efficiency of using alcohol in the process. The study indicates that reaction using high ratio of alcohol (1 : 7) generally produced high yield of the biodiesel compared to other ratios. The yield of the biodiesel also increased with increasing temperature over all the reaction systems. The carbon modified with sulphuric acid catalyst showed the highest yield of ~90 %, which was obtained at 80 °C using a 1 : 7 ratio of WCO : alcohol. It was also observed that reaction with methanol produced better yields compared to ethanol reactions where significant differences were observed across both temperature and ratio. The catalysts were characterized using Fourier Transform Infrared Spectroscopy, X-ray powder diffraction and surface area and pore volume analyses. The catalyst is of interest because it is green, non-toxic and synthesized using cassava peel waste.
Metaphorical nominations characterizing the conceptual sphere of the mechanism (Based on the English popular science Biology discourse)
Authors:   Saratov State University, Filatova Anna V.
Published: December 2022

The paper aims at identifying the connection between the target domain and the source domain (represented by the PARTS OF MECHANISM, MECHANISM REPAIR, MECHANISM ACTIVATION). The author uses continuous sampling method, as well as methods of conceptual and component analysis, in order to elicit multiple target domains and the mapping principle. The sentences under research (512 metaphorical expressions) were taken from various British and American popular science journals on Biology. The author considers the key works written in the field of conceptual metaphor (G. Lakoff, E. Maccormac), linguistic picture of the world (D. Berdnikova, S. Dracheva), written by the Russian linguists. The theoretical analysis is finished by a review of the works in the sphere of the popular science and scientific discourses and the place of metaphor in them (O. Desyukevich, S. Chistyukhina, E. Mazyar, E. Mityukova). In the course of the material description the author has drawn some conclusions about the way the English conceptualize biological processes. It is important to note that most frequently the metaphorical meaning is a broader, more general one, whereas in other cases, it alternatively makes the object or a process more specific, or it can have a completely opposite meaning. Molecule, cell, bacteria, fungi and viruses serve as target domains, which can be explained by the immense significance of the processes that lay the “foundation” of human life. A very extensive metaphorical thesaurus of the mechanism conceptual domain is indicative of this conceptual domain being well-structured. It is worthy of note that the lexemes with the denotational meaning of stopping are barely present in the research which means that the described genes, molecules and cells are doing a never-ceasing job of maintaining life on earth.