bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Characterization of Secondary and Tertiary Layers of a Multilayer Wound Dressing System
Authors: Kubera Sampath Kumar S. , Prakash C. , Vaidheeswaran S. , Karthic Kumar B. , Subramanian S.
Published: November 2018

A nonwoven secondary layer was produced from silk fibroin by a compression and spunlacing method. Super absorbent polymer (SAP) was added to the nonwoven mat to increase the exudates and absorption capacity and manage the moisture in the wound site. Three types of tertiary layers, viz., cotton gauze cloth, adhesive tape, and polyurethane film, were experimented on for the properties that are essential for those layers. The structural stability was found to be better in the spunlaced nonwoven compared to the compressed nonwoven. The Phosphate Buffer Saline (PBS) absorption of the nonwoven increased with an increase in the concentration of SAP percentage. The PBS absorption was found to be lower for the spunlaced nonwoven because of the higher fiber entanglement and packing compared to that of the compressed nonwoven. The vapor permeation rate (grams per square meter a day) across the nonwoven mat decreased with an increase in grams per square meter, and there was no effect from the SAP percentage added to the nonwoven mats. Horizontal and vertical wicking of the spunlaced nonwoven was better than that of the compressed nonwoven. The results showed that spunlaced nonwoven would be a better material for the secondary layer. The vapor transmission rate was highest for cotton gauze cloth, followed by adhesive tape and film. The multilayer wound-dressing system consisting of primary, secondary, and tertiary layers was tested for PBS vapor transmission rate and bacterial penetration. The results showed that the wound-dressing system made from film and adhesive tape did not allow the Staphylococcus aureus bacterial culture to penetrate through the wound-dressing system.
Psychological effects of dopamine agonist treatment in patients with hyperprolactinemia and prolactin-secreting adenomas
Authors: Ioachimescu Adriana G , Fleseriu Maria , Hoffman Andrew R , Vaughan III T Brooks , Katznelson Laurence
Published: November 2018

Background

Dopamine agonists (DAs) are the main treatment for patients with hyperprolactinemia and prolactinomas. Recently, an increasing number of reports emphasized DAs’ psychological side effects, either de novo or as exacerbations of prior psychiatric disease.

Methods

Review of prospective and retrospective studies (PubMed 1976, September 2018) evaluating the psychological profile of DA-treated patients with hyperprolactinemia and prolactinomas. Case series and case reports of psychiatric complications were also reviewed.

Results

Most studies were cross-sectional and had a control group of healthy volunteers or patients with nonfunctioning pituitary adenomas. There were few prospective studies, with/without control group, that included small numbers of patients. Compared with controls, patients with hyperprolactinemia generally had worse quality of life, anxiety, depression and certain personality traits. Patients receiving DAs had higher impulsivity scores than normoprolactinemic controls. Impulse control disorders (ICDs) were reported in both genders, with hypersexuality mostly in men. Multiple ICDs were sometimes reported in the same patient, usually reversible after DA discontinuation. In case reports, DA therapy was temporally associated with severe depression, manic episodes or psychosis, which improved after discontinuation and administration of psychiatric medications. Gender type of DA, dose and duration of therapy did not correlate with occurrence of psychiatric pathology.

Conclusion

Patients with hyperprolactinemia receiving DAs may develop changes in mood and behavior regardless of prior psychiatric history. Increased awareness for ICDs, depression, mania and other types of psychosis is needed by all physicians who prescribe DAs. Larger prospective controlled clinical studies are needed to delineate prevalence, risk stratification and management.
Prevalence of moderate-to-severe TR suitable for percutaneous intervention in TTE patients
Authors: Teoh Z. H. , Roy J. , Reiken J. , Papitsas M. , Byrne J. , Monaghan M. J.
Published: November 2018

Moderate-to-severe tricuspid regurgitation is associated with higher mortality and morbidity yet remains significantly undertreated. The reasons for this are complex but include a higher operative mortality for patients undergoing isolated tricuspid valve surgery. This study sought to determine the prevalence of patients with moderate-tosevere tricuspid regurgitation and identify those who could be potentially suitable for percutaneous tricuspid valve intervention by screening patients referred for transthoracic echocardiography (ECHO) at a tertiary center. Our results showed that the prevalence of moderate-to-severe tricuspid regurgitation in our total ECHO patient population was 2.8%. Of these, approximately one in eight patients with moderate-to-severe tricuspid regurgitation would be potentially suitable for percutaneous intervention and suggests a large, unmet clinical need in this population.
Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging
Authors: Gilbreath Ebony T , Jaganathan Lakshmikripa , Subramanian Madhan , Balasubramanian Priya , Linning Katrina D , MohanKumar Sheba M J , MohanKumar Puliyur S
Published: November 2018

Women are chronically exposed to estrogens through oral contraceptives, hormone replacement therapy or environmental estrogens. We hypothesized that chronic exposure to low levels of estradiol-17β (E2) can induce inflammatory and degenerative changes in the tuberoinfundibular dopaminergic (TIDA) system leading to reduced dopamine synthesis and hyperprolactinemia. Young (Y; 3–4 months) and middle-aged (MA; 10–12 months) Sprague–Dawley rats that were intact or ovariectomized (OVX) were either sham-implanted or implanted with a slow-release E2 pellet (20 ng E2/day for 90 days). To get mechanistic insight, adult 3- to 4-month-old WT, inducible nitric oxide synthase (iNOS) and IL-1 receptor (IL-1R) knockout (KO) mice were subjected to a similar treatment. Hypothalamic areas corresponding to the TIDA system were analyzed. E2 treatment increased IL-1β protein and nitrate levels in the arcuate nucleus of intact animals (Y and MA). Nitration of tyrosine hydroxylase in the median eminence increased with E2 treatment in both intact and OVX animals. There was no additional effect of age. This was accompanied by a reduction in dopamine levels and an increase in prolactin in intact animals. E2 treatment increased nitrate and reduced dopamine levels in the hypothalamus and increased serum prolactin in WT mice. In contrast, the effect of E2 on nitrate levels was blocked in IL-1R-KO mice and the effect on dopamine and prolactin were blocked in iNOS KO animals. Taken together, these results show that chronic exposure to low levels of E2 decreases TIDA activity through a cytokine-nitric oxide-mediated pathway leading to hyperprolactinemia and that aging could promote these degenerative changes.
vqtl: An R Package for Mean-Variance QTL Mapping
Authors: Corty Robert W , Valdar William
Published: November 2018

We present vqtl, an R package for mean-variance QTL mapping. This QTL mapping approach tests for genetic loci that influence the mean of the phenotype, termed mean QTL, the variance of the phenotype, termed variance QTL, or some combination of the two, termed mean-variance QTL. It is unique in its ability to correct for variance heterogeneity arising not only from the QTL itself but also from nuisance factors, such as sex, batch, or housing. This package provides functions to conduct genome scans, run permutations to assess the statistical significance, and make informative plots to communicate results. Because it is inter-operable with the popular qtl package and uses many of the same data structures and input patterns, it will be straightforward for geneticists to analyze future experiments with vqtl as well as re-analyze past experiments, possibly discovering new QTL.
Hacia un ñandereko latinoamericano: identidad de resistencia e integración contrahegemónica
Authors: FRIGGERI Félix Pablo
Published: November 2018

En este trabajo se problematiza la integración latinoamericana desde la articulación de las luchas populares contrahegemónicas y desde la construcción de identidades de resistencia al avance del capitalismo neoliberal enraizadas en las tradiciones antiimperialistas. Se destaca cómo la dimensión contrahegemónica ha estado presente cada vez que hubo avances reales en este proceso de integración. Se analiza el papel y las posibilidades que las luchas populares tienen en el mismo y cuáles son los espacios de construcción de estas articulaciones y búsquedas identitarias. También cómo este proceso de integración desde abajo, desde los pueblos, desde las organizaciones populares, puede aportar a repensar la llamada Teoría de las Relaciones Internacionales desde América Latina en un enfoque descolonizador epistémico-político. Se propone el concepto de ñandereko latinoamericano, partiendo de la idea guarani de una identidad contrastiva, intercomunitaria que afirma una vida en comunidad igualitaria entre los hombres y en profunda relación con la naturaleza, como fuente de inspiración en la construcción de identidades de resistencia y unión latinoamericanas.
Resistencias y alternativas al desarrollo en América Latina y Caribe: luchas sociales contra el extractivismo
Authors: ECHART MUÑOZ Enara , VILLARREAL VILLAMAR María del Carmen
Published: November 2018

La represión creciente de las resistencias al modelo de desarrollo vigente hacen del mundo un lugar peligroso para los activistas. Según Naciones Unidas (2017), tres de cada cuatro asesinatos de defensores de derechos humanos ocurren en las Américas, de los cuales 41% eran contrarios a proyectos extractivistas o defendían el derecho a la tierra y a los recursos naturales de los pueblos indígenas. Partiendo de esa realidad, este artículo analiza el papel de los movimientos sociales en las disputas sobre los sentidos del desarrollo en América Latina y Caribe, con foco en las luchas contra el extractivismo. Para ello, se ha realizado un mapeamiento de estas luchas a partir de un banco de datos con 259 conflictos en torno a la minería, desarrollado por el Grupo de Relaciones Internacionales y Sur Global (GRISUL), para mostrar sus impactos en diversas dimensiones (como medio ambiente, género, territorios indígenas, desplazamientos de población, entre otros), así como los procesos de criminalización surgidos frente a los mismos. Además, mostraremos también la tendencia regional de construcción de alternativas al modelo extractivista dominante.
Clinical Risk Factors for Revisits for Children With Community-Acquired Pneumonia
Authors: Ambroggio Lilliam , Herman Helena , Fain Emily , Huang Guixia , Florin Todd A.
Published: November 2018

BACKGROUND:

Children discharged from the emergency department (ED) with community-acquired pneumonia (CAP) revisit for several reasons, including disease progression or treatment failure. Understanding factors associated with revisits may assist clinicians in preventing subsequent visits.

METHODS:

Children aged 3 months to 18 years with an International Classification of Diseases, Ninth Revision diagnosis of CAP between December 1, 2009 and April 31, 2013 were eligible. The primary outcome was a CAP-related ED visit or hospitalization within 30 days of the index visit. The secondary outcome was a CAP-related ED visit within 48 hours of discharge from the index visit. The association between clinical variables and an ED revisit for children with CAP was assessed by using multivariable logistic regression models.

RESULTS:

Of the 3304 index ED visits by patients with CAP, 148 (4.5%) revisited the ED. Children with complex chronic conditions (CCCs) were 2.23 times as likely to revisit the ED as those without a CCC (95% confidence interval: 1.29–3.86). Children admitted and those who received aminopenicillins at the index visit were less likely (63% and 49%, respectively) to revisit the ED (95% confidence interval: 0.24–0.56 and 0.30–0.85, respectively).

CONCLUSIONS:

Although children with CAP have a relatively low revisit rate to the ED, patients who received aminopenicillins at their index visit were statistically less likely to revisit when adjusting for markers of severity (eg, age, CCCs, and disposition at index visit). Clinical factors alone, however, may not be the only indicators of revisits, and additional factors may need to be considered in future studies.
Adherence to AAP Healthy Newborn Discharge Criteria in a Tertiary Care Children’s Hospital
Authors: Arora Nonie S. , Danicek Anne M. , Osborn Rachel R. , Fried Sarah Q. , Negris Olivia R. , Lychuk Karson , Mychaliska Kerry P. , Skoczylas Maria S. , Monroe Kimberly K.
Published: November 2018

OBJECTIVES:

In 2015, the American Academy of Pediatrics (AAP) published an updated consensus statement containing 17 discharge recommendations for healthy term newborn infants. In this study, we identify whether the AAP criteria were met before discharge at a tertiary care academic children’s hospital.

METHODS:

A stratified random sample of charts from newborns who were discharged between June 1, 2015, and May 31, 2016, was reviewed. Of the 531 charts reviewed, 433 were included in the study. A review of each chart was performed, and data were collected.

RESULTS:

Descriptive statistics for our study population (N = 433) revealed that all 17 criteria were followed <5% of the time. The following criteria were met 100% of the time: clinical course and physical examination, postcircumcision bleeding, availability of family members or health care providers to address follow-up concerns, anticipatory guidance, first appointment with the physician scheduled or parents knowing how to do so, pulse oximetry screening, and hearing screening. These criteria were met at least 95% to 99% of the time: appropriate vital signs, regular void and stool frequency, appropriate jaundice and sepsis management, and metabolic screening. The following criteria were met 50% to 95% of the time: maternal serologies, hepatitis B vaccination, and social risk factor assessment. Four of the criteria were met <50% of the time: feeding assessment, maternal vaccination, follow-up timing for newborns discharged at <48 hours of life, and car safety-seat assessment.

CONCLUSIONS:

Our data reveal that the AAP healthy term newborn discharge recommendations are not consistently followed in our institution.
The Rapidity of Advancement of Feedings in Premature Infants: Evidence Basis and Current Recommendations
Authors: Garg Shalabh , Sinha Sunil
Published: November 2018

It is every neonatologist’s aspiration to achieve “optimal postnatal growth” in preterm infants, because nutrition and growth of this population affect long-term neurodevelopmental outcomes. However, despite having this common goal, there are huge variations in the enteral feeding practices of preterm infants across the globe. One such practice is the rate of advancement of enteral feedings; there is no consensus about the optimal approach, even among international nutritional experts. In this review, we aim to provide readers with the rationale for different practices in feeding advancement and summarize the current literature.
Parental Personal Sense of Duty as a Foundation of Pediatric Medical Decision-making
Authors: Feudtner Chris , Schall Theodore , Hill Douglas
Published: November 2018

We describe a model of parental (or more broadly, surrogate) decision-making that includes 5 aspects of decision-making that other models simplify or omit. First, we describe problem structuring recognizing that parents often face multiple potential problems or decisions with multiple potential solutions, rather than a single problem, and the initial challenge is deciding which of the problems to focus on. Second, we discuss sense-making recognizing that difficult decisions are not made in isolation but are often part of a confusing, labyrinthian situation in which disoriented parents must make a series of decisions over time in hopes of getting closer to 1 or more goals. Third, we describe path dependency recognizing that decisions influence what and how decisions are made later. Fourth, we discuss personal sense of duty recognizing that parents and other surrogate decision-makers have central personal roles, self-identities, and relationships with the patient, culminating in a personal sense of duty, such as what they perceive they should do to be in their own judgment a “good parent,” which substantially affects their decision-making. Fifth, we describe self-judgments recognizing that parents experience distress when they judge themselves as falling short of their duties or if they think others are judging them for falling short. Clinical practice, medical ethics, and research regarding decision support can all benefit by acknowledging and addressing these key aspects of medical decision-making.
Creating the Safety and Respect Necessary for “Shared” Decision-making
Authors: Halpern Jodi
Published: November 2018

Beyond the rhetoric of bioethics, patients and families need help facing tragic diagnoses and prognoses and coping with traumatic treatment options. In this article, I will draw from developmental psychology, psychodynamic psychotherapy, and bioethics to show what we are still missing about shared decision-making and how we can do better. Before we bring in new models of shared decision-making we need to ensure that doctors know how to create the foundational conditions for safe emotional communication. For pediatricians, this requires knowing enough about how adolescents process cognitive, affective and sensory information to avoid traumatizing their patients, knowing enough about the doctor’s own fears not to project them onto the patient, and providing the supportive others that help the teenager tolerate and process information that is otherwise intolerable. To fail to do so can lead to tragic outcomes.
Titrating Clinician Directiveness in Serious Pediatric Illness
Authors: Morrison Wynne , Clark Jonna D. , Lewis-Newby Mithya , Kon Alexander A.
Published: November 2018

Shared decision-making in pediatrics is based on a trusting partnership between parents, clinicians, and sometimes patients, wherein all stakeholders explore values and weigh options. Within that framework, clinicians often have an obligation to provide guidance. We describe a range of ethically justifiable clinician directiveness that could be appropriate in helping families navigate serious pediatric illness. The presentation of “default” options and informed nondissent as potential strategies are discussed. The degree of clinician directiveness may vary even for decisions that are equally “shared.” A myriad of factors affect how directive a clinician can or should be. Some of the most important factors are the degree of prognostic certainty and the family’s desire for guidance, but others are important as well, such as the urgency of the decision; the relationship between the clinician, patient, and family; the degree of team consensus; and the burdens and benefits of therapy. Directiveness should be considered an important tool in a clinician’s armamentarium and is one that can be used to support families in stressful and emotionally difficult situations.
Walk the talk – Using a shared terminology within writing education for eight- to ten-year-olds
Authors: Kristoffersen Cherise S.
Published: November 2018

This article reports on a study with the main hypothesis that active use of a shared metalinguistic terminology will assist teachers and students in their writing development. To test this hypothesis an intervention study was designed involving professional development sessions with teachers over two years. The sessions introduced and negotiated a shared metalinguistic terminology and strategically planned how to contextualize the shared terminology in dialogue with the teachers. The building of a shared terminology was based upon the following traits: ideas, organization, voice, conventions, word choice and sentence fluency. For the purposes of this study, I concentrate on the traits of word choice and sentence fluency as previous research indicates a lack of shared vocabulary in these areas. The quantitative results are from 101 students ages eight to ten producing 404 texts. The texts were scored on word choice and sentence fluency by four teachers. The statistical results indicate a large effect size. In discussing these findings, the contextualization of the shared terminology is considered through interviews and evaluations with teachers. The findings may provide indicators for the use of the shared terminology and for how the terminology was successfully embedded in writing, teaching and learning practices of the classrooms.
Formulations as way of providing renditions in mediated interactions
Authors: Baraldi Claudio
Published: November 2018

Studies on interpreted-mediated interactions show that the function of interpreting as mediation is based on interpreters’ actions that modify other participants’ original utterances. The effects of interpreters’ modifications of participants’ original utterances include negative selection of information, i.e. ‘gatekeeping’, as well as language mediation as successful coordination of the interaction. Many of the studies show the importance of interpreters’ modifications of original utterances for the coordination of interactions between participants speaking different languages. The present paper analyzes audio-recorded interactions at an Immigrant Support Centre, in which one mediator provides interpreting between Italian social workers and immigrants who speak West African English. The analysis is based on a theoretical approach concerning communication processes, the design of the mediator's actions in the interaction, and the function of interpreting as mediation at the Immigrant Support Centre. In particular, the analysis concerns the design of the mediator's expansions of social workers’ explanations as different types of formulations, consisting in explicating or developing the gist of these explanations. The mediator's formulations highlight her participation in providing support for the immigrants and the function of mediation in narrowing the gap between the institutional narrative and the immigrants’ narratives.
ASPECTOS SOCIOECONÔMICOS DAS ASSOCIAÇÕES DA COLÔNIA DE PESCADORES E AQUICULTORES DO MUNICÍPIO DE APODI – RN
Authors: Vale Sabrina Deise Pereira , Costa Franklin Roberto da
Published: November 2018

O trabalho teve como objetivo analisar as manifestações que ocorrem no espaço geográfico decorrente da atividade pesqueira das associações de pescadores e aquicultores do município de Apodi, visando conhecer as condições de vida e de trabalho e montar um perfil socioeconômico de 35 famílias de pescadores. Para isso, foram utilizados dados de caráter primário e secundário para a obtenção de informações que nos nortearam no decorrer do estudo. Em um primeiro momento a pesquisa constitui um breve histórico sobre a pesca e as colônias de pescadores no país e a influência destas nas comunidades tradicionais. Em um segundo momento há a caracterização da área estudada seguida pela discussão dos resultados obtidos, analisando e caracterizando a área pesquisada e o perfil socioeconômico dos pescadores do município. Os fatores analisados apontaram para uma intensificação dos problemas sociais e econômicos vividos e percebidos pelos pescadores. Mas por outro lado, a permanência e persistência dos pescadores em darem continuidade à atividade pesqueira, mesmo em pequena escala, apontam para a necessidade de garantir o uso múltiplo dos recursos naturais do município.
AVALIAÇÃO DE TREINAMENTO PROFISSIONAL PARA TRABALHADORES DO CONHECIMENTO: um estudo de caso em uma instituição pública de educação, ciência e tecnologia do Nordeste do Brasil
Authors: Castro Ahiram Brunni Cartaxo de , Oliveira Rinaldo Medeiros Alves de , Neto Ezequiel da Costa Soares , Oliveira Marcos Antônio de , Silva Arthur William Pereira da , Silva Pablo Marlon Medeiros da
Published: November 2018

O objetivo desta pesquisa foi avaliar o suporte organizacional para aprendizagem e o impacto do Curso de Aperfeiçoamento em Gestão Pública na percepção dos gestores Técnico-Administrativos em Educação de uma instituição pública de educação, ciência e tecnologia do Nordeste do Brasil. Trata-se de uma pesquisa qualitativa, com modo de investigação no estudo de caso e de objetivo descritiva. Para o levantamento dos dados utilizou-se de entrevista estruturada por meio do MAIS (Modelo de Avaliação Integrado e Somativo), proposto por Jairo Borges-Andrade, Gardênia Abbad e Luciana Mourão. Os dados coletados foram tratados em planilhas eletrônicas e os resultados demonstram que: quanto ao suporte organizacional, existiram condições organizacionais favoráveis e havia compromisso da organização com a aprendizagem das novas competências dos trabalhadores, bem como, houve a absorção pelos indivíduos/ grupos de trabalho sobre o quanto a organização valoriza suas contribuições de novos conhecimentos. Quanto ao impacto do treinamento, tem-se que ficou constatado que houve melhorias no desempenho individual dos servidores treinados através de uma nova forma de desempenhar antigas tarefas a partir das novas competências adquiridas.
UM BREVE ESTUDO SOBRE OS ALGORITMOS DOS VAGA-LUMES E DOS MORCEGOS PARA OTIMIZAÇÃO DE FUNÇÕES DE REFERÊNCIA
Authors: Leite Izabele , Marcone Marcos , Paiva Fábio
Published: November 2018

Uma alternativa para resolver problemas complexos de otimização é usando algoritmos meta-heurísticos. As meta-heurísticas são métodos aproximados que oferecem soluções aceitáveis para problemas de otimização. Nos últimos anos, algumas meta-heurísticas inspiradas no comportamento de animais da natureza, em especial aqueles que vivem em grupos, vêm sendo bastante utilizadas. Este trabalho tem como objetivo apresentar um breve estudo do desempenho de duas meta-heurísticas conhecidas como Algoritmo dos Vaga-lumes e Algoritmo dos Morcegos. A comparação é realizada por meio de vários experimentos computacionais para otimizar funções de referência clássicas da literatura. Para isso, foram realizadas 30 execuções independentes, considerando diferentes dimensões e quantidade de avaliações da função objetivo. Após os experimentos, alguns dados estatísticos foram apresentados e eles evidenciaram a superioridade do Algoritmo dos Vaga-lumes quando comparado com o Algoritmo dos Morcegos.
ADOÇÃO E USO DA AGRICULTURA DE PRECISÃO NA REGIÃO DAS MISSÕES DO RIO GRANDE DO SUL
Authors: Antonini Rafael Cippolat , Bortolotto Rafael Pivotto , Zamberlan João Fernando , Dalla Nora Douglas , Pasini Mauricio Paulo Batistella , Fiorin Jackson Ernani
Published: November 2018

Embora sendo cada vez mais adotada no Brasil, existem poucos estudos sobre o processo de adoção e uso de tecnologias de AP no país. O objetivo deste estudo foi avaliar a percepção, grau de adoção e perfil dos produtores rurais quanto à utilização da técnica de AP na Região Noroeste do RS. O trabalho caracterizou-se como uma pesquisa exploratória quanto a sua finalidade. O público-alvo da entrevista foram produtores rurais assistidos pela Cooperativa Tritícola Regional São-Luizense Ltda. Para a obtenção das descrições experienciais de cada produtor foram utilizados questionários semiestruturados, sendo um com perguntas abertas e fechadas e outro utilizando-se a Escala Likert. Os dados foram analisados calculando-se a frequência das respostas dadas e análise de discurso, e a associação entre as variáveis e os produtores investigados foi identificada mediante o uso de análise estatística multivariada. A AP ainda é recente na Região Noroeste do RS, sendo utilizadas poucas ferramentas, restringindo-se à aplicação à taxa variável de insumos, muito centrada na produção de soja, principalmente. É utilizada por produtores de diferentes níveis de escolaridade, idade e tamanho de área.
EFEITOS DE SURFACTANTES NA ORGANOFILIZAÇÃO DE ARGILAS BENTONÍTICAS PARA USO EM FLUIDOS DE PERFURAÇÃO DE BASE MICROEMULSIONADA
Authors: Garnica Alfredo Ismael Curbelo , Curbelo Fabíola Dias da Silva , Magalhães Renata Rodrigues , De Sousa Roxana Pereira Fernandes
Published: November 2018

A principal indústria consumidora da argila bentonítica é a indústria petrolífera, pois a utiliza como viscosificante de fluidos de perfuração tanto base água quanto base óleo, sendo, neste último, necessário submeter o argilomineral a um processo conhecido como organofilização. Os fluidos não aquosos apresentam grande aplicabilidade, entretanto possuem um alto custo e elevada toxicidade. É nesse contexto, que os fluidos microemulsionados estão sendo desenvolvidos, para a faixa de aplicação dos fluidos de base não aquosa, visando um menor custo e baixa toxicidade. Nesse sentido, este trabalho teve como objetivo avaliar a interação de argilas organofilizadas pelos tensoativos Ultranex NP-40, Tween 80 e Praepagen, com dois meios microemulsionados do tipo água em óleo (A/O), sendo a fase oleosa do sistema I, a n-parafina e do sistema II, o óleo de pinho. O estudo se iniciou com a construção dos diagramas de fases de cada sistema. As argilas organofílicas e in natura foram analisadas por difração de raio X (DRX) e inchamento de Foster. Pelo DRX pôde-se observar um aumento na distância interplanar das argilas organofílicas, em relação a argila in natura (14,46 Å). No inchamento de Foster, observou-se que a microemulsão de parafina foi a que apresentou maior interação com as argilas modificadas. Os resultados mostraram que a argila organofilizada com Praepagen apresentou os melhores resultados, uma distância interplanar de 49,08 Å e um inchamento alto na microemulsão de parafina.
Editorial
Authors: Leite José Yvan Pereira
Published: November 2018

A HOLOS publicado o seu quarto número de 2018 com  18 artigos. Os artigos abordam temas das várias áreas do conhecimento, entre elas, bibliometria, educação, engenharias, ensino, gestão e turismo. Estas advém da África do Sul, Brasil, Chile e Portugal.Entre 22 e 28 de outubro realizou-se no mundo a semana internacional do acesso aberto, iniciativa que tem como objetivo disseminar o Acesso Aberto ao conhecimento em escala global. Neste contexto a HOLOS nasce com este objetivo e deseja ampliar seu alcance nos mais diversos quadrantes do globo, bem como faz esforços para a ampliação da cultura Open Acess.Informamos ainda a comunidade acadêmica que outros números da HOLOS estão em fase de diagramação e serão publicados em breve.Por fim, convido-os a acessar os novos artigos publicados! Prof. José Yvan Pereira Leite
ESTIMATIVA E DISTRIBUIÇÃO DE PRECIPITAÇÕES DECENDIAIS PARA O ESTADO DO PARANÁ
Authors: Sampaio Silvio César , Queiroz Manoel Moisés Ferreira de , Frigo Elisandro Pires , Longo Adair José , Suszek Morgana
Published: November 2018

ESTIMATIVA E DISTRIBUIÇÃO DE PRECIPITAÇÕES DECENDIAIS PARA O ESTADO DO PARANÁ  Silvio César Sampaio; Manoel Moisés Ferreira de Queiroz; Elisandro Pires Frigo; Adair José Longo; Morgana SuszekSetor de Recursos Hídricos e Saneamento Ambiental (RHESA), Universidade Estadual do Oeste do Paraná,  Cascavel, Paraná, ssampaio@unioeste.br  1 RESUMO O objetivo deste trabalho foi estimar a precipitação provável com 75% de probabilidade nos períodos decendiais, a partir de dados diários de precipitação de 22 postos de medição, com um mínimo de 12 anos de observação, fazendo-se uso das distribuições Gama e Log-normal. Os testes Qui-quadrado e Kolmogorov-Smirnov, ambos com 5% de significância, foram utilizados para verificar a aderência das distribuições às condições pluviométricas decendiais do estado do Paraná. Os resultados mostraram que a distribuição Gama ajustou-se mais adequadamente às condições pluviométricas do estado nos períodos estudados. Os meses mais chuvosos são janeiro e fevereiro, enquanto os mais secos, são julho e agosto. O estado do Paraná apresenta aumento na quantidade de precipitação pluviométrica na direção litoral/oeste e norte/sul. UNITERMOS: probabilidades, chuva provável, distribuição Gama, distribuição log-normal.  SAMPAIO, S.C.; QUEIROZ, M.M.F. de; FRIGO, E.P.; LONGO, A.J.; SUSZEK, M.DISTRIBUTION AND ESTIMATE OF PROBABLE 10-DAY PRECIPITATION INPARANÁSTATE  2 ABSTRACT The objective of this study was to estimate the probable 10-day precipitation, 75% probability, using daily rainfall data from 22 rain gauge sites, which had been collecting observation data for at least 12 years; Gamma and Log-normal distributions were used. Qui-square and Kolmogorov-Smirnov tests, at 5% significance, were utilized to verify distribution adherence to 10-day rainfall conditions in the state of Paraná. The results showed that Gamma distribution was more adequately adjusted to rainfall conditions in the studied periods than Log-normal distributions. January and February are the rainiest months whereas July and August are the driest ones. There is an increase in the east/west and north/south bound rainfall inParanastate. KEYWORDS: probabilities, probable rainfall, gamma distribution, log-normal distribution.
DISTÂNCIA DA REDE ELÉTRICA QUE VIABILIZA O USO DE MOTORES DIESEL EM ÁREAS IRRIGADAS DO BRASIL
Authors: Monteiro Rodrigo Otávio Câmara , Ferraz Priscylla , Coelho Rubens Duarte , Santos Ronaldo Antônio do
Published: November 2018

DISTÂNCIA DA REDE ELÉTRICA QUE VIABILIZA O USO DE MOTORES DIESEL EM ÁREAS IRRIGADAS DO BRASIL  Rodrigo Otávio Câmara Monteiro; Priscylla Ferraz; Rubens Duarte Coelho; Ronaldo Antônio do SantosEscola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo, Piracicaba, SP rocamara@esalq.usp.br  1 RESUMO             Na maioria das regiões do país, a energia elétrica aparece como a alternativa, economicamente mais viável, no acionamento de bombas em áreas irrigadas, o que justifica seu uso por aproximadamente 70% dos irrigantes. No entanto, em determinadas situações, não se dispõe, nas proximidades, de rede elétrica, o que passa a viabilizar o uso de motores diesel. Este trabalho, portanto, propôs a análise dos custos horários de bombeamento com a operação de motores diesel e elétricos nas 5 regiões do Brasil. Considerou-se as composições tarifárias verde, azul e convencional, período de irrigação de 2, 4, 6 e 8 meses por ano e operação no horário de ponta e fora de ponta. Para essa avaliação, foi considerado um motor diesel e elétrico, de potência comercial de 50 cv. O ponto de equilíbrio entre motor elétrico e diesel foi determinado pela distância da rede de energia elétrica até o local de consumo. A viabilidade de utilização dos motores diesel em relação ao acionamento de motores elétricos foi encontrada a partir de distâncias da rede de transmissão elétrica de1,32 a8,71 km, sendo a primeira a condição mais atrativa, encontrada na região Sudeste, com 2 meses/ano de irrigação, na tarifa convencional. UNITERMOS: Energia elétrica, irrigação, custo de bombeamento  MONTEIRO, R. O. C.; FERRAZ, P.; COELHO, R. D.; SANTOS, R.A. do. VIABILITY OF DIESEL MOTOR USE IN IRRIGATED AREAS OF BRAZIL DUE TO DISTANCE FROM ELECTRIC POWER LINES  2 ABSTRACT In most agricultural areas ofBrazil, electric power seems to be the most feasible economic alternate methods for the functioning of pumps in irrigated areas, therefore 70%  of irrigation systems use it. However, the viability of electric power lines is restricted to only one part of rural areas, making it necessary the implementation of diesel engines as a source of electrical power for water management. The aim of this study was to investigate the viability of the use of electric energy and diesel motors.  For this study, an electric motor and a diesel one, both of 50HP potency, were evaluated, taking into consideration the following variables: tax composition, areas of the country and number of operation hours per year. The viability of the diesel engine use in relation to implantation of electric motors was determined from  distances that ranged from1.32 kmup to8.71 kmbetween the consumption place and the electric power lines. The most favorable condition is the one found in  the southeast of the country: 2 irrigation months/year.KEYWORDS: Electric energy, irrigation, pump costs
Observations on the Activities of Certain Serum Enzymes and Levels of Some Biochemical Parameters in Spent Horses with Liver Damage
Authors: AGINA Onyinyechukwu Ada , IHEDIOHA John Ikechukwu
Published: November 2018

Clinical biochemistry tests are one of the tests designed to assess the functional status of the liver in domestic animals and man. This study evaluated the activities of some serum enzymes and the level of some biochemical parameters in horses with acute and chronic liver damage. This study was carried out in Nigerian horses presented for sale at the Obollo Afor horse depot, Udenu Local Government Area, Enugu State Nigeria. A total of 100 adult Nigerian horses of either sex were studied once a week for a period of 24 weeks. Serum biochemistry parameters indicated for the assessment of liver function were evaluated following standard procedures. These parameters include: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total proteins, albumin, globulin, total cholesterol, total bilirubin and urea. Based on the outcome of the serum biochemistry evaluation, the horses were assigned into 3 groups namely: apparently healthy horses (Group 1), horses with biochemical markers of acute liver damage (Group 2) and horses with biochemical markers of chronic liver damage (Group 3). The mean serum ALT, AST, ALP and total bilirubin values of group 2 horses were significantly (p < 0.05) higher than those of groups 1 and 3 horses. The mean serum albumin value of group 2 horses was significantly (p < 0.05) lower than that of groups 1 and 3 horses. There was no significant (p > 0.05) difference in the mean serum urea value of group 2 and 3. A significantly (p < 0.05) lower serum creatinine value was observed in group 2 horses. There were no significant (p > 0.05) differences in the mean serum total protein, globulin and cholesterol values across the groups. In the spent horses, acute liver damage was characterized by increased serum ALT, AST and ALP activities, and decrease in creatinine level, hyperbilirubinemia, slight hypoalbuminemia, normal total protein, globulin and cholesterol levels while chronic liver damage was characterized by decreased serum ALT activity, normal serum AST and ALP activities, decreased serum urea level, normal total protein, albumin, globulin, total bilirubin and cholesterol levels.
Fungal and Insect Pests of the Edible Mushroom Pleurotus ostreatus
Authors: OYEBAMIJI Gbemisola H. , JONATHAN Gbolagade S. , AKINYEMI Damilare S. , POPOOLA Kehinde K.O.
Published: November 2018

Pleurotus ostreatus is an edible mushroom cultivated worldwide, with economic, nutritional and medicinal values, which requires a shorter growing period compared to other edible mushrooms. Fungal and insect pests of cultivated P. ostreatus were examined. Fungi from infected mother spawn of P. ostreatus were isolated, characterized and identified, while various insect pests on P. ostreatus were also collected and analysed. The plates showing micrographs, morphological and cultural characteristics of fungal isolates obtained were recorded. Fungi species isolated from infected mother spawn of P. ostreatus were identified as Aspergillus flavus, A. niger, Cladosporium sp., Penicillium oxalicum, Fusarium oxysporium and F. verticilliodes. The growth of Cladosporium sp. was slow on Potato Dextrose Agar (PDA) plates compared to Aspergillus sp. and Fusarium sp. which was very fast. Insect belonging to the orders Collembola, Diptera and Araneae were encountered on the cultivated P.ostreatus. These groups of insects were found at adult stage of life. Infestation by order Collembola (springtail) on P. ostreatus was found to be higher in incidence with percentage composition of 50.0%, followed by order Diptera (fruit flies) and order Araneae (spider) with 33.3% and 16.67% composition respectively. Distinguishing features of each pest and the features of damage done on mushroom were also observed and recorded.
Reflections on Practice
Authors: Wilhelmsen Christine , Fuhr Gisle
Published: November 2018

This article presents and discusses three examples of relational processes in music therapy collaborations with adolescents in care of child welfare services. Theory on relational work in psychology, child welfare, and music therapy will be presented in order to describe the theoretical foundation of our approach. We reflect on different aspects of the therapeutic relationship, such as the distribution of roles and responsibilities between the therapist and adolescent, the need for patience, and the value of the musical cooperation in the relationship. Bordin’s theory on the therapeutic alliance functions as a framework for the discussion. We conclude that music activities can be a beneficial approach for giving adolescent in child welfare positive relational experiences with adult caregivers.
Takotsubo Cardiomyopathy During Anti-HER2 Therapy for Metastatic Breast Cancer
Authors: Lees Caitlin , Yazdan-Ashoori Payam , Jerzak Katarzyna J. , Gandhi Sonal
Published: November 2018

Human epidermal growth factor receptor 2 (HER2)-targeted antibodies, including pertuzumab and trastuzumab, improve overall survival and progression-free survival among women with HER2-positive metastatic breast cancer, but grade ≥3 cardiotoxicity occurs in approximately 8% of cases. Here we report a case of Takotsubo cardiomyopathy associated with the use of dual anti-HER2 therapy in a 63-year-old woman who presented to the emergency department with an 8- to 10-hour history of progressive dyspnea after completing her third cycle of pertuzumab plus trastuzumab in addition to nab-paclitaxel chemotherapy. To our knowledge, this patient represents the first reported case of Takotsubo cardiomyopathy associated with pertuzumab plus trastuzumab combination therapy in the literature.
Modulation of Premetastatic Niche by the Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor Pazopanib in Localized High-Risk Prostate Cancer Followed by Radical Prostatectomy: A Phase II Randomized Trial
Authors: Maughan Benjamin L. , Pal Sumanta K. , Gill David , Boucher Kenneth , Martin Christopher , Salgia Meghan , Nussenzveig Roberto , Liu Ting , Hawks Josiah L. , Batten Julia , Nachaegari Gayatri , Stephenson Robert , Lowrance William , Jones Jeremy , Dechet Christopher , Agarwal Neeraj
Published: November 2018

Lessons Learned

Pazopanib was not effective in altering the premetastatic niche in the neoadjuvant setting. Pazopanib was safe and well tolerated without any new safety signals.

Background

Vascular endothelial growth factor receptor 1 (VEGFR1) expressing myeloid-derived suppressor cells (VEGFR1+ MDSCs) potentially foster metastases by establishing a premetastatic niche. In a preclinical study, VEGFR1+ clustering in lymph nodes (LNs) independently predicted time to biochemical recurrence (TTBR) in localized prostate cancer [1]. The hypothesis was that neoadjuvant pazopanib therapy will decrease VEGFR1+ clusters in pelvic lymph nodes and improve outcomes.

Methods

This is a phase II trial (NCT01832259) of neoadjuvant pazopanib 800 mg versus placebo daily for 4 weeks in high-risk localized prostate cancer. The primary endpoint was a decrease in VEGFR1+ MDSC clustering assessed by immunohistochemistry (IHC) analysis. Secondary endpoints were safety, feasibility, and TTBR.

Results

Thirty patients were randomized to pazopanib versus placebo, with 15 patients randomized to each arm. Demographic and disease characteristics were similar in both arms. There was no difference in the VEGFR1+ clustering between the treatment arms (p = .345). Neoadjuvant therapy with pazopanib was well tolerated, and surgical complications were similar in both arms.

Conclusion

Neoadjuvant pazopanib therapy did not alter the premetastatic niche; however, treatment targeting vascular endothelial growth factor (VEGF) in the preoperative period was safe and feasible, which may open up the avenue to investigate novel combinatorial regimens, including a VEGF inhibitor in combination with immune checkpoint inhibitor in this setting.
Macroeconomic Effects of Defense Expenditures in Turkey
Authors: ŞİT Mustafa
Published: November 2018

In

this study, the effects of defense expenditure on the macroeconomic majorities

of Turkey such as economic growth, inflation, current account balance, import

and employment have been investigated. 

The relation in question has been analysed over the period between

1980-2016 by structural breaks unit root test, causality tests of Toda-Yamamoto

and Granger. As a result of this study, it has been detected that defense

expenditures are effective on inflation, current account balance and import.

Unlike previous studies which same tests were applied, causality from current

account balance and GDP to defense expenditures was determined in this article.

Evidence has shown that, for Turkish economy, defense expenditures are

effective on macroeconomics variables.
Psychoanalysis Outside the Clinic: An approach of Psychosocial Studies
Authors: Busygina N.P.
Published: November 2018

In the article a new approach to research called “psychosocial studies” is examined. According to the author historically an alliance of qualitative research methodology with psychoanalysis played a decisive role in the development of psychosocial studies. Psychoanalysis was rethought as a variation of social criticism whose purpose is to undrstand how power, types of exploitation and other macrosocial features of society affect and are affected by modes of mental and emotional functioning. Examples of psychoanalytic informed psychosocial studies are analyzed. It is shown that psychoanalysis helps to rethink and even to overcome the traditional dualism of psychic and social, of that is “in-here” and that is “out-there”.
Visual methods in socio-psychological research
Authors: Mel’nikova O.T. , Mezentseva A.S.
Published: November 2018

The methodological and historical background of the use of visual methods in social and psychological research is considered. The advantages of a multimodal approach to the analysis of social phenomena are discussed; the main ways of including visual data in qualitative research are systematized. The key areas and directions of research using the visual approach are outlined. An attempt is made to organize all the variety of visual studies, from the use of visual data as an aid to the analysis of visual data as such. The main groups of visual studies use images 1) as a means of visualizing the results; 2) as an incentive to initiate discussion; 3) as an addition to verbal information that helps self-disclosure; 4) as a way to Express their views or relationships; 5) as an independent goal of the study. Despite the prevalence of verbal research methods in psychology, human ideas about the world are multimodal, so the use of a multimodal research strategy is designed to enrich knowledge about the person and his place in the social world.
Deep hermeneutics in visual analysis (on an example of W. Allen’s movie Zelig)
Authors: Sokolova E.T. , Khoroshilov D.A.
Published: November 2018

By the example of analysis of the Woody Allen’s movie Zelig the ego-states phenomenology of borderline personality with split identity is presented, of a person with inclination to various transfigurations (chameleonization), who deeply feels his foreignness in the social context, in the diversity of false facades and absurd conformism, which are designed to compensate the inner feeling of emptiness and emotional hunger with the help of manipulations. The clinical phenomenon resonates with the contemporary sociocultural trends of the society of transitivity and designates the risks of clinical deviations in the conditions of uncertainty and vagueness of boundaries of personal and social space. Deep hermeneutics, implemented in the methodology of visual analysis, is considered as a practice of research of modern culture and mass consciousness, which reveals such a scientific trend as the search for transdisciplinary intersections of clinical and social psychology in the study of social and cultural phenomena.