bluuebunny/crossref_metadata_2025 huggingface dataset:
Moving from Conventional to Online Instruction: Students’ Perspectives from the Global COVID-19 Lockdown
Authors: Akaadom Bernard Wiafe , Agyekum Francis Kwaku , Forson Justina Mariam
Published: April 2024

The effects of COVID-19 caused (and is still causing) incomparable disruption to higher education everywhere although it has improved in 2021 to some extent with students now returning (or returned) to campuses. In 2020 somewhere around February, in a matter of days or weeks, campuses around the world went quiet as countries were locked down to contain the spread of the virus. Universities had to develop quick and innovative responses that would enable them to continue to offer teaching and learning when staff and/or students did not have access to a physical campus. An immediate, practical challenge for campus universities was to mobilize and assist teachers in designing and implementing alternative assessment models and scale learning support for specific units that did not rely on face-to-face presentations. This study examined the digital devices students use to access online lectures, the perceived benefits they gained, and the challenges they faced during the lockdown when they had to resort to distance learning during the global lockdown. A non-experimental descriptive design was chosen in which a number of undergraduate and graduate students were randomly selected to participate in the study. A sample size of 260 students was drawn with a simple random sample in which the subjects responded to a carefully designed structured instrument. It was found that there was no correlation between the use of technology for online teaching and the challenges they faced during the period. It was also found that students gained experience attending online lectures during the pandemic. There was an overwhelming response of motivation for students to engage in online lectures. Students were happy with the student-teacher interactions as they affirmed there was enough time given by instructors for them to ask questions or sought clarifications on issues that were not clear to them. In a sharp contrast, it emerged that there were some difficulties going online as compared to face-to-face instruction. They indicated again that there was frustration and lack of interest in learning while being locked down. Conversely, there was lack of direct face-to-face contact with lecturers which respondents deemed was quite frustrating.
Reducing salt intake as a first step to prevent hypertension
Authors: Lazić Vesna , Mulić Maida , Todorović Milena , Stanić Slobodan , Maksimović Katarina , Obrenović Milan
Published: April 2024

People consumed salt exclusively through food millions of years ago, which amounted to less than 0.5 g/day. Recent researches indicate that the average daily consumption of salt is more than 10 g/day. The general conclusion of studies investigating the relationship between dietary salt intake and blood pressure led to recommendations on reducing salt intake and limiting total intake to 5 g of salt per day by the World Health Organization and the European Safety Agency of Food. Increased salt intake causes suppression of the Renin-Angiotensin-Aldosterone system by reducing sodium renal excretion. Also, an increase in salt intake leads to an increase in the concentration of sodium in the blood, which causes high secretion of vasopressin and causes high blood pressure. Namely, bread is a basic food and is high in salt, but the salt parameter is not mandatory in accordance with the regulations. Today, almost every EU country has different strategies that include recommending salt reduction through food reformulation to reduce the salt content of food, including bread and bakery products. Achieving and maintaining the reduction of the population's salt intake will soon give a great benefit in terms of the prevention of cardiovascular events as the first cause of death globally, then great savings for the health system and an individual.
The importance of media literacy for members of the military
Authors: Kljajić Nebojša
Published: April 2024

Abstract: The phrase "media literacy" is becoming ever more present in daily communication. The importance of media literacy is a significant guide for the orientation of members of the military in contemporary media arena dominated by a pronounced dichotomy in the field of effects of media content. New media have given numerous advantages to the life of a modern man. On the other hand, the hyperproduction of false news, fabricated information and interpretations, which often mix fragments of truth and falsehood, have created information disorder in the public sphere having a powerful potential to adversely affect decision-making process, combat morale, reputation and the system of values of soldiers and military leaders. Every day, mass communication media produce narratives which have become a powerful weapon for the production of meaning and reality construction. Media literacy should not be observed solely as a defensive paradigm and a shield against harmful effects of media content, but as a powerful mechanism to recognise and use all those benefits offered by modern digital technologies. The aim of this work is to point out the need to raise awareness of the importance of media literacy as an important competence of members of 21st century military.
Arsitektur Ergonomi pada Fasilitas Komersil Living World Mall di Denpasar Bali
Authors: Wiriantari Frysa , Widiyani Desak Made Sukma
Published: April 2024

Living Word Mall is a commercial facility located on Jalan Gatot Subroto Timur, North Denpasar. Its attractive design invites a lot of people's attention to visit. As a commercial facility that accommodates many users, especially visitors, Living World Mall should apply ergonomic architecture as part of its design. This research will focus on the implementation of ergonomics architecture at the Living World Mall commercial facility in Denpasar Bali in terms of safety, comfort and productivity. These three things will be accompanied by accessibility facilities such as ramps and stairs, space spacing and building health (building physics) which are applied to Living World Mall commercial buildings. This study used descriptive qualitative method. Some of the primary data were obtained from field observations and also the results of interviews with visitors who were active in the mall. Interviews with users were conducted to find out the problems that exist at the research locus to find alternative solutions. The purpose of this research is to examine the use of ergonomic architecture in Living World Mall. The use of qualitative descriptive research methods can be used as a reference in our research because we aim to describe the conditions observed specifically in this area. The results of the study show that the design of Living World Mall has implemented a design that refers to ergonomics for its users. Although there are several parts that need more emphasis primarily related to safety, comfort and productivity factors.
Peran Civitas Akademika IPBI Dalam Menjalin Makna Sosial Pada Kegiatan Beach Clean Up di Kuta
Authors: Pradana Gede Yoga Kharisma
Published: April 2024

Tujuan penulisan artikel ini adalah untuk mengungkap peran civitas akademika IPBI pada kegiatan beach clean up di Kuta. Beach clean up merupakan suatu program kegiatan IHGMA untuk menjaga dampak positif dari perkembangan pariwisata Bali. Namun, ternyata realisasi kegiatan beach clean up melibatkan peran civitas akademika IPBI. Permasalahannya : 1) Bagaimana bentuk kegiatan beach clean up di Kuta 2) Apa makna sosial dari kegiatan beach clean up di Kuta 3) Bagaimana peran civitas akademika IPBI dalam kegiatan beach clean up di kuta. Penyusunan luaran hasil kegiatan ini diselesaikan dengan metode kualitatif. Data primer kegiatan ini berhasil dikumpulkan melalui observasi partisipasi. Hasil studi pustaka telah dipergunakan sebagai data sekunder. Keseluruhan data dianalisis dengan menggunakan teori praktik dan teori strukturasi. Hasil menunjukan bahwa : 1) Kegiatan beach clean up di Kuta telah direalisasikan dalam bentuk kegiatan gotong-royong membersihkan sampah pada area pantai; 2) Makna sosial dalam kegiatan beach clean up di Kuta adalah pengabdian kepada masyarakat, kebersamaan, kerjasama, tenggang rasa untuk membangun konsensus sampah sebagai ancaman kerusakan lingkungan alam dan disensus kerusakan lingkungan alam di sektor pariwisata; 3) Peran civitas akademika IPBI dalam menjalin makna sosial pada kegiatan beach clean up di Kuta adalah sebagai peserta.
Capítulo 15: Impacto de la capacitación en las competencias personales de los colaboradores de una Universidad Pública ICA-2021 en Perú
Authors:   Universidad Nacional San Luis Gonzaga, Mercado Solari Eduardo Ricardo , Garavito Lurita Luis Fernando ,   Universidad Nacional San Luis Gonzaga, Canchari Vásquez Uldarico ,   Universidad Nacional San Luis Gonzaga, Navarro de Bernaola Carmen ,   Universidad Nacional San Luis Gonzaga, Bernaola Ramos Juan Teodoro ,   Universidad Nacional San Luis Gonzaga, Navarro Mendoza Roger ,   Universidad Nacional San Luis Gonzaga
Published: April 2024

La investigación tuvo como propósito analizar la influencia de la capacitación en el desarrollo personal del trabajador en la Universidad Nacional San Luis Gonzaga, año 2021. En tal sentido, se sustentó la problemática con el maco teórico y datos de campo suficientes para validar los resultados arribados. En relación al rigor científico y metodológico, la investigación fue de tipo básica con enfoque cuantitativo; de nivel descriptivo y explicativo, porque se identificaron los elementos de la realidad; siendo el diseño no experimental transversal. Las técnicas para recolección de datos fueron: la encuesta y el análisis documental con sus respectivos instrumentos cuestionario y revisión de documentos; para procesar los datos se consideró: clasificación de datos, tabulación de datos, tablas y representaciones estadísticas y para comprobar los resultados se utilizó la técnica estadística del Chi – Cuadrado. Con una población 860 y una muestra de 266 trabajadores administrativos en estudio. En consecuencia, de acuerdo a la comprobación de la hipótesis, siendo los resultados el valor obtenido de 687.62 que supera al valor crítico de 43.773; se llegó a la siguiente conclusión: la capacitación en sus dimensiones desempeño laboral, objetivo, estrategia metodológica y programas de capacitación influyen significativamente en el desarrollo personal del trabajador en la Universidad Nacional San Luis Gonzaga.
Capítulo 6: Encendiendo el debate: cómo la identidad, la aceptación social y el marketing moldean la decisión de los jóvenes de fumar
Authors:   Universidad Tecnológica del Perú, Giménez López Bruno César , Godoy Laurente Lucy Verónica ,   Universidad Tecnológica del Perú, Cuba Cornejo Carmen Luz ,   Universidad Tecnológica del Perú, Cornejo Purilla Sugey Pilar ,   Universidad Tecnológica del Perú, Del Pino Ascona Dennís Yvonne ,   Universidad Tecnológica del Perú, Delgado Ruidias Eufemia Socorro ,   Universidad Tecnológica del Perú, Junes del Pozo Jhojan Ramiro ,   Universidad Tecnológica del Perú
Published: April 2024

El objetivo de este estudio fue examinar la relación entre la decisión de los jóvenes de comenzar a consumir tabaco y la búsqueda de identidad, la necesidad de aceptación social, las redes sociales y las tácticas de marketing de la industria tabacalera. El enfoque de la investigación fue cuantitativo, de tipo no experimental, prospectivo, y transversal, de alcance correlacional, para una población de 932 jóvenes entre 18 y 27 años, con un muestreo de tipo no probabilístico por conveniencia, con una muestra final de 343 jóvenes de ambos sexos a quienes se les realizaron encuestas estructuradas. Los resultados mostraron que el 42.3% de los encuestados presentaron un nivel de autoestima alto, en el que los hombres fueron del 72.5%, en comparación con el de las mujeres de 53.4% y no se encontró una relación significativa entre los niveles de autoestima y el consumo de tabaco (p > 0.05). Por otro lado, el 52.8% tiene, al menos un padre que fuma, proporción que disminuyó significativamente (p=0.015) en los no fumadores (39.5%). Además, existe una relación significativa (p<0.05) entre la influencia de padres y/o los pares y el consumo de tabaco para un nivel de significancia del 5%. Como también, mientras que el 47,4 % de los jóvenes afirma que está de moda el consumo de tabaco porque lo hacen actores, streamers, influencers, entre otros, quienes los consumen mientras trasmiten contenido por sus redes sociales. Además, los resultados también sugieren que los adolescentes que recibieron publicidad sobre el consumo de tabaco mostraron más actitudes favorables hacia los cigarrillos, en el que los hombres fueron del 32.8%, en comparación con el de las mujeres de 23.4%. Como conclusión los autores indican que la triangulación de estas variables proporcionó una comprensión integral de las dinámicas subyacentes en la decisión de fumar de los jóvenes.
Role of Social Networks in Shaping Health Behavior of Chinese Adolescents
Authors: Qi Xiaowei
Published: April 2024

Aim: The access to social media websites has developed people's social media awareness. Often the misuse of social media adversely affects human behaviour and human health. The prime objective of this study was to provide practical guidelines to the Chinese government for improving
the appropriate use of social media with recommended findings to improve the health behaviour of adolescents. Methods: This research used a sample of 382 individuals collected with a survey-based questionnaire using a simple random sampling approach. The data collected for this research
was analysed using the R Package programming software RStudio. Resutls: The findings of this research highlighted the factors that significantly impact adolescents' health behaviour, such as frequency of social media use, peer influence, parental involvement, access to health information,
and cultural influence. Conclusion: This study contributes to the body of knowledge with the critical findings based on the empirical evidence. These findings also address the inconsistencyfound in the previous literature. The Chinese government is required to work on this study's findings
to improve the role of social media in adolescents' health behaviour.
Evolución y retos del sistema educativo mexicano en los albores del siglo XXI
Authors: Morales Hernández Ramiro , Rodríguez Cruz Yuridia , Morales Benítez Brenda Ivonne
Published: April 2024

El presente artículo analiza la evolución y retos del Sistema Educativo Mexicano por los cambios de las políticas públicas de educación implementadas a través de la Ley General de Educación, por las distintas administraciones de gobierno en el país. El trabajo se realizó bajo la metodología cualitativa y comprendió una revisión documental de fuentes de información secundaria sobre el tema. Se concluye que las políticas encaminadas al desarrollo de la educación en México, si bien es verdad, han permitido enfrentar desafíos que demanda la sociedad mexicana, también es cierto que en el año 2020, persisten retos de rezago educativo por atender para avanzar hacia la configuración de bases sólidas de desarrollo educativo.
Individualised treatment of COPD exacerbations using biomarkers
Authors: Sivapalan Pradeesh , Eklöf Josefin , Bonnesen Barbara , Tønnesen Louise , Wilcke Torgny , Jensen Jens-Ulrik Stæhr
Published: April 2024

This review highlights key aspects of treating chronic obstructive pulmonary disease (COPD) exacerbation, focusing on the optimisation of systemic corticosteroid and antibiotic use through personalised treatment using biomarkers. Eosinophil-guided therapy reduces corticosteroid usage which might reduce side effects, while procalcitonin-guided therapy contributes to reduced antibiotic consumption. These approaches, documented through well-conducted randomized controlled trials, suggest the possibility of enhancing COPD exacerbation management, reducing potential side effects, and addressing concerns related to antibiotic resistance.
The use of telemedicine in lung diseases with focus on chronic obstructive pulmonary disease
Authors: Olesen Astrid Baumann , Raunbak Sabine Michelsen , Mathiesen Rikke Bækkely Sass , Lauridsen Marie Dam , Hansen Nikolaj Brix , Weinreich Ulla Møller
Published: April 2024

Telemedicine is emerging and has both clinical, scientific, and political interest. In this review, we present the present literature on implementation and describe the economic considerations when implementing telemedicine in chronic obstructive pulmonary disease (COPD). The use of telemedicine in COPD is well-received by patients, but there is little evidence to suggest its superiority to standard outpatient care or to support better outcomes for patients. Thus, local settings and cost effectiveness should be considered during the implementational process.
Integration of the ARCS Motivational Model in Digital Game-based Learning for Sustaining Student Engagement in Communication
Authors: Ghani Mohammad Taufiq Abdul , Daud Wan Ab Aziz Wan , Manan Kamaruzzaman Abdul
Published: April 2024

Digital game-based learning is an instructional method that teaches students through games and other forms of entertainment. Digital games have the potential to naturally drive players to participate in an activity, which can be beneficial for learning. One of the essential factors in achieving success in second language acquisition is motivation. This research seeks to present a digital game-based learning framework integrated with the ARCS motivating paradigm to achieve this goal. Each of the four primary motivational factors elements is represented by an ARCS component. Attention (A), Relevance (R), Confidence (C), and Satisfaction (S) are the four components of motivation. This paper provides a high-level overview of the suggested framework, which is divided into three parts: input, process, and output. It is possible that the framework proposed will be useful to a wide range of stakeholders, including students, instructional designers, programme designers, and language practitioners. This research described a method for developing a successful digital game that included motivating components to keep learners engaged throughout the learning process.
INTERPRETATION OF THE ETHNIC THEME IN THE CHORAL WORKS OF PĒTERIS VASKS (THROUGH THE EXAMPLE OF MATE SAULE AND ZĪLES ZIŅA)
Authors: Копосова И.В. , Витоль А.А.
Published: April 2024

В творчестве ведущего современного автора Петериса Васкса хоровая музыка занимает важное место. В своих сочинениях для хора композитор соединил национальные традиции и возможности современных композиторских техник, в первую очередь, сонорики и алеаторики. Этот союз ярче всего представлен в сочинениях 1970-х – начала 1980-х. Два из них – «Mate saule» на стихи Яниса Петерса и «Zīles ziņa» на стихи Улдиса Берзиньша – анализируются в статье с позиций воплощения национальной темы, значимой для композитора. В процессе анализа показаны принципы работы с поэтическим текстом, выделены композиционные и драматургические особенности каждого хора, обозначены особенности тематизма и приёмов работы с ним, охарактеризована трактовка сонорных и алеаторных приёмов. Соотнесение основных мотивов стиха и комплекса музыкально-выразительных средств, используемых в каждом хоре, позволило сделать вывод, что национальная тема трактуется по-разному – в идиллическом («Māte saule») и в драматическом («Zīles ziņa») ключе.

Choral music is an integral part of the works of the leading contemporary composer Pēteris Vasks. In his choral compositions he combined the national traditions and resources of the modern composing techniques, most particularly, sonorism and aleatoric music. This union is most accurately represented in the compositions of the 1970s-early 1980s. The article studies two of those – Mate saule to a poem by Jānis Peters and Zīles ziņa to a poem by Uldis Bērziņš – with regard to the implementation of the ethnic theme crucial to the composer. The analysis presents the approach to work with a poetic text, highlights the compositional and dramaturgic aspects of each choir, specifies the aspects of thematic material and methods of work with thereof, and defines the interpretation of sonorant and aleatoric techniques. The matching of the main motifs of a poem and a set of musical and expressive means used in each choir allowed to conclude that the ethnic theme is interpreted in various ways – in an idyllic (Māte saule) and a dramatic (Zīles ziņa) sense.
MUSICAL FEATURES OF THE FAREWELL TUNE AND SEND-OFF SONGS OF THE VALA RIVER BASIN UDMURTS
Authors: Иванова Н.П.
Published: April 2024

Данная работа посвящена изучению удмуртского свадебного напева ныл келян гур и жалобной песни невесты, которые звучат в момент прощания девушки с родным домом и являются необходимым компонентом обряда проводов невесты. Структурно-типологический анализ поэтических текстов проводных/прощальных напевов, уровня ритмической организации, мелодической композиции и звуковысотного строения свидетельствует об их принадлежности к достаточно позднему стилевому пласту удмуртского музыкального фольклора.

This article is devoted to the study of the Udmurt wedding tune nyl kelyan gur and the bridal lament that are performed at the moment of the girl's farewell to her own home and are an essential component of the bride's farewell ceremony. The structural and typological analysis of poetic texts of farewell/send-off tunes, the level of rhythmic organization, melodic composition and pitch structure indicates that they belong to a later stylistic layer of Udmurt musical folklore.
Migraines in Women: A Focus on Reproductive Events and Hormonal Milestones
Authors: Kim Seonghoon , Park Jeong Wook
Published: April 2024

Migraine, a prevalent neurological disorder, is more common in women than in men. This sex difference is more pronounced after menarche and diminishes after menopause. Migraines in women are influenced by the menstrual cycle, pregnancy, and lactation, suggesting a connection to sex hormones, known as the estrogen withdrawal theory. Beyond endogenous hormonal changes accompanying reproductive events, exogenous hormonal factors such as contraceptives or hormone replacement therapy may also affect migraines. The hormonal influence cannot be explained simply by serum estrogen levels; instead, it involves a complex interplay of various factors. Here, we delineate aspects of migraines associated with endogenous and exogenous hormonal changes over the course of a woman’s life, exploring the mechanisms and contributing factors through which sex hormones influence migraines.
Multi-Threshold Image Segmentation for Lung Cancer Image Mining
Authors: Samatha G
Published: April 2024

In the medical image mining, the mining pattern is directly depending upon the features, which are extracting from images at the pre-processing stage. Therefore accurate and robust segmentation is essential to estimate these parameters for quantitative assessment of medical images in order to achieve correct clinical diagnosis. Global threshold determination for a lung CT image based on histogram much simpler and less time consuming process, but it fails to segment the image more effectively. In order to overcome this limitation, a new method, based on an iterative-Otsu optimization approach is proposed for multi-thresholds determination. The objective of this work is to estimate the lung nodule size more accurately by utilizing “between class-variance” criterion of Otsu method in an iterative way. The algorithm runs through n-number of iterations and exits when reaches a preset threshold difference value. We applied this method on few lung CT images from the National Lung Screening Trail database to verify the proposed methodology against single threshold results. The extracted features are presented for the comparison. The preliminary results show that the proposed algorithm is better performing in estimate the nodule size efficiently for Lung CT images.
Collegiate flight students' willingness to pilot in different aircraft sanitization scenarios
Authors: Wheeler Brooke , Shacknai Jesse , Valluzzi Nicholas , Li Tianhua
Published: April 2024

The COVID-19 pandemic has added an entirely new dimension to flight education and training, thus highlighting the importance of understanding student perceptions of training in the close quarters of small, piston aircraft. Schools and institutions across the world have developed cleaning procedures and policies to mitigate the spread of COVID-19 while continuing collegiate programs. Flight schools face a greater challenge relating to the sanitization and the scheduling of an aircraft because social distancing in a light training aircraft is impossible, and an aircraft is particularly challenging to clean because of sensitive equipment and numerous touch surfaces. We used a stratified cluster sample of Part 141 collegiate flight students from the core Aeronautics courses to recruit participants at all levels of training for a questionnaire. Ninety-seven responses were collected. The within-subjects design presented four aircraft sanitization scenarios in a random order to each participant to determine willingness to pilot (Rice et al., 2020) under various sanitization procedures: (1) assignment to an aircraft at random with no sanitization or scheduling procedures, (2) assignment to an aircraft at random with an Instructor who is responsible for the cleaning of the aircraft with alcohol wipes, (3) assignment to an aircraft that is specifically assigned to the same Instructor and his/her students, and (4) assignment to an aircraft that is specifically assigned to the same Instructor and his/her students every day and Instructor who is responsible for the cleaning of the aircraft with alcohol wipes. Sanitization scenarios with more precautions resulted in a higher willingness to pilot measurements.
School vouchers for greater educational equity
Authors: Hussein Abdelnasser
Published: April 2024

Providing public funding to parents to pay children's tuition at private and religious schools has been a matter of debate over the last three decades based on claims such as the lack of accountability in private schools, an increase in segregation, and the fact that it contradicts the principle of the separation between church and state. Such concerns are legitimate, but they need to be discussed considering the new literature that proves the efficacy of private schools, both religious and non-religious, in terms of student achievement, test results, and graduation rates. A thorough look at the test results revealed by the National Assessment of Educational Progress (NAEP) over the last decade indicates that students' scores in private schools are higher than their peers in public schools. NAEP results and the recent empirical studies conducted in states like Florida, Wisconsin, and Washington DC confirmed that the voucher system works well. This information provides compelling evidence that policymakers need to review the private school voucher policies. Hence, this article highlights the efficacy of school vouchers based on recent empirical studies and the academic results of the students enrolled in school?voucher programs. The available data assures that there is no point in depriving students of their right to choose private or religious schools as their peers who choose charter and magnet schools.
A Comparative Look at the Duty to Mitigate Loss: the Consequences of the Violation of This Duty
Authors:   Department of Civil Law, Faculty of Law, Bilkent University, Turkey, Altinok Ormanci Pınar
Published: April 2024

The duty to mitigate loss is a general principle of law that serves to limit the liability of the party that has caused injury to the extent that the injured party has not demonstrated the diligence expected from the latter. However, this duty also serves the purpose of ensuring economic efficiency. While the classic understanding requires that, according to the principle of pacta sunt servanda, the interests of the injured party should be prioritized, today, the contract also refers to the cooperation between the parties. Therefore, reduction in the amount of claimable compensation should not be the sole sanction vis-à-vis the injured party that has violated the duty to mitigate loss. Otherwise, the injured party may escape the consequences of having violated the duty to mitigate loss by resorting to other optional rights. However, in order to ensure economic efficiency, in case the injured party violates the duty to mitigate loss, sanctions should also be foreseeable in terms of other optional rights. This study will evaluate the effect of the violation of the duty to mitigate loss in particular, with regards to request for specific performance and rescission of contract.
The Challenges of European Union Integration: The Parallel between Human Rights and Corruption Perceptions
Authors:   Faculty of Law, South East European University, North Macedonia, Ahmedi Blerta , Stojchevska Stefani ,   Faculty of Law, South East European University, North Macedonia
Published: April 2024

With the concepts of rule of law, democracy and respect for human rights representing the most prominent values upon which the European Union is established, the EU accession process expectedly supplicates candidate countries to ameliorate the efficiency of their legal institutions. As a general rule, such fundamentals are habitually correlated with other equally relevant criteria concerning the EU accession process. Given that the Western Balkans are not ordinarily regarded as an exemplary model in terms of practically demonstrating the rule of law and economic well-being, this research paper analyzes the linear relationship between human rights and rule of law manifestations and corruption perspectives in some EU candidate countries as a potential mechanism for satisfying EU accession fundamentals. For that matter, a simple linear regression analysis was conducted in order to determine whether and how such correlation would benefit policymakers in some current EU candidate countries toward their paths to European integration.
pengaruh profitabilitas dan leverage terhadap nilai perusahaan melalui kebijakan dividen sebagai variabel intervening pada perusahaan manufaktur yang terdaftar BEI periode 2018-2022
Authors: Silvia afrelia  , Mondra Neldi  , Dodi Suryadi
Published: April 2024

Silvia Afrelia, 20101155310142, jurusan manajemen keuangan, tahun 2018-2022, Pengaruh Profitabilitas Dan Leverage Terhadap Nilai Perusahaan Melalui Kebijakan Dividen Sebagai Variabel Intervening Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Pada Periode 2018-2022. Dibawah bimbingan I bapak Dr. Mondra Neldi, SE., MM dan pembimbing II bapak Dodi Suryadi,SE., MMPenelitian ini bertujuan untuk mengetahui seberapa besar pembahasan Pengaruh Profitabilitas Dan Leverage Terhadap Nilai Perusahaan Melalui Kebijakan Dividen Sebagai Variabel Intervening Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Pada Periode 2018-2022. Metode dokumentasi dan jenis data sekunder. Metode dokumentasi yang digunakan adalah analisis jenis data sekunder. Hasil penelitian yang didapatkan berdasarkan uji parsial (uji t) diperoleh : Profitabilitas secara parsial berpengaruh signifikan terhadap Kebijakan Dividen Pada Perusahaan Manufaktur Yang Terdaftar Di BEIhasil analisis menunjukkan Profitabilitas memiliki nilai probability sebesar 0,00 lebih kecil dari 0,05 atau (0,00 < 0,05), Leverage secara parsial berpengaruh signifikan terhadap Kebijakan Dividen Pada Perusahaan Manufaktur Yang Terdaftar Di BEI hasil analisis menunjukkan Leverage memiliki nilai probability sebesar 0,00 lebih kecil dari 0,05 atau (0,00 < 0,05), Profitabilitas secara parsial tidak berpengaruh signifikan terhadap Nilai Perusahaan Pada Perusahaan Manufaktur Yang Terdaftar Di BEI dimana hasil analisis menunjukkanProfitabilitas memiliki nilai probability sebesar 0,31 lebih besar dari 0,05 atau (0,31 > 0,05), Leverage secara parsial berpengaruh signifikan terhadap Nilai Perusahaan Pada Perusahaan Manufaktur Yang Terdaftar Di BEI dimana hasil analisis menunjukkan Leverage memiliki nilai probability sebesar 0,00 lebih kecil dari 0,05 atau (0,00 < 0,05), Kebijakan Dividen secara parsial berpengaruh signifikan terhadap Nilai Perusahaan Pada Perusahaan Manufaktur Yang Terdaftar Di BEI dimana hasil analisis menunjukkan Kebijakan Dividen memilikinilai sebesar 0,00 lebih kecil dari 0,05 atau (0,00 < 0,05), Profitabilitas secara parsial berpengaruh signifikan terhadap Nilai Perusahaan dengan Kebijakan Dividen Sebagai Variabel Intervening Pada Perusahaan Manufaktur Yang Terdaftar Di BEI dimana hasil perkalian antara nilai beta X1 terhadap Z dengan nilai beta Z terhadap Y yaitu : 0,253 * 0.275 Maka pengaruh total yang diberikan X1 terhadap Y adalah jumlah pengaruh langsung dan tidak langsung yaitu : 0.069, Leverage secara parsial tidak berpengaruh signifikan terhadap Nilai Perusahaan dengan Kebijakan Dividen Sebagai Variabel Intervening Pada Perusahaan Manufaktur Yang Terdaftar Di BEI dimana perkalian antara nilai beta X2 terhadap Z dengan nilai beta Z terhadap Y yaitu : 0.431 * 0.275 Maka pengaruh total yang diberikan X2 terhadap Y adalah jumlah pengaruh langsung dan tidak langsung yaitu : 0.118
Kajian Hermeneutika Hans Gorg Gadamer dan Relevansinya Dengan Pendidikan Agama Islam
Authors: Salimah Binti
Published: April 2024

Kata hermeneutika itu sendiri berasal dari bahasa Yunani hermeneuien, yang memilki arti menafsirkan. Maka kata hermeneutika secara harfiah dapat diartikan sebagai penafsiran dan interprestasi. Istilah Yunani ini mengingatkan kita pada tokoh mitos yang bernam Harmes, yaitu seorang utusan untuk menyampaikan pesan jupiter kepada manusia. Berkiblat pada Martin Heidegger, Gadamer pun mempercayai bahwa hermeneutika salah satu pencarian proses universal dari tindakan pemahaman tentang adanya sesuatu. Pemahaman mesti dipandang sebagai sikap yang fundamental dalam kehidupan manusia, atau mungkin lebih tepatnya mengerti  merupakan suatu jalan berada manusia sendiri. Oleh sebab itu, eksistensi manusia itu disertai dengan pemahaman itu sendiri. Hermeneutika Gadamer adalah suatu pemahaman terhadap suatu teks itu dengan didibatkan dengan berbagai teori dan unsur yang menyertainyai yaitu dialog, sejarah dan bahasa. Hermenetika relevan dengan dunia pendidikan baik itu pendidikan umum ataupun pendidikan agama Islam. Dan dalam pembelajaran ada proses hermenetika.
Croyances en crise dans le contexte de la Covid-19 en France : autoethnographie d’un pragmatiste contrarié
Authors: Darras Bernard
Published: April 2024

Cette étude de sémiotique pragmatiste examine une confrontation de croyances au sujet de la crise sanitaire en France. De février 2020 à novembre 2022, l’auteur a assisté et participé à la montée de deux récits d’abord consensuels, puis antagonistes et finalement incompatibles. C’est la dynamique de ces récits croisés qui est explorée et analysée à partir des concepts peirciens de croyance, de doute et des quatre méthodes de fixation des croyances. L’étude aborde aussi les processus d’assertion et de discrédit réciproque des données, des informations et des désinformations. Les trois protagonistes des échanges n’échappent pas non plus à ces discrédits qui se déroulent dans un contexte de rapports de pouvoir où le doute est confronté à la montée du soupçon. Le corpus de la recherche est très situé, et même personnalisé, puisqu’il concerne la relation à distance de l’auteur avec deux interlocutrices. À sa façon réflexive, critique, mais aussi autocritique, cette étude porte sur la construction et la déconstruction des croyances en situation d’incertitude et d’inconnu provoquée par la crise de la Covid-19.
De la critique théorique à la critique de la société : penser le concept de réification chez Gilles Deleuze et Félix Guattari
Authors: Richert Fabien
Published: April 2024

Dans cet article, j’examine les points de rencontre possibles entre l’oeuvre de Deleuze et Guattari et la théorie critique de l’École de Francfort afin d’établir leur complémentarité. L’hypothèse que je défends est que c’est à partir d’un concept phare de la théorie critique, la réification, qu’il est possible d’opérer un rapprochement productif entre les penseurs de l’École de Francfort et Deleuze et Guattari. Dans la première partie, le concept de réification et le rôle que celui-ci a joué dans la pensée critique allemande sont présentés (Marx, Lukács, Adorno). Cet exercice doit permettre de mesurer la pertinence du concept de réification pour établir une double critique : critique théorique et critique de la société. Dans la seconde partie, je montre comment cette double critique traverse la pensée deleuzo-guattarienne.
Présentation
Authors: Levesque Simon
Published: April 2024

Dans cet entretien, réalisé en anglais puis traduit en français et édité par Simon Levesque, Susan Petrilli discute de sa carrière universitaire, des jalons qui ont marqué celle-ci et des projets qui continuent de l’animer. Petrilli aborde notamment ses collaborations intellectuelles avec Thomas Sebeok et Augusto Ponzio, ses recherches et travaux pour revitaliser la pensée de Victoria Welby, ainsi que l’influence profonde sur sa pensée des écrits de Charles Sanders Peirce, Mikhaïl Bakhtine, Ferruccio Rossi-Landi et Emmanuel Levinas. Un des objectifs de ce dialogue est d’interroger la place et l’importance de la critique dans la sémioéthique. En l’inscrivant dans un paradigme critique, Petrilli défend la pertinence et l’actualité de cette approche qu’elle a développée pour penser divers problèmes qui affectent notre monde contemporain. Le dialogue est organisé autour des thèmes du vivre-ensemble, de l’altérité, de la précarité, des changements climatiques, de la responsabilité, de l’écoute et du soin.
Victoria Welby
Authors: Petrilli Susan
Published: April 2024

Partie 2 de 9. Cet entretien a été réalisé en anglais, puis traduit en français et édité par Simon Levesque.
Philosophie et science
Authors: Petrilli Susan
Published: April 2024

Partie 6 de 9. Cet entretien a été réalisé en anglais, puis traduit en français et édité par Simon Levesque.
Sur l’avenir des études sémiotiques
Authors: Petrilli Susan
Published: April 2024

Partie 9 de 9. Cet entretien a été réalisé en anglais, puis traduit en français et édité par Simon Levesque.
Troubling Records
Authors: Regehr Cheryl , Regehr Kaitlyn , Birze Arija , Duff Wendy
Published: April 2024

Video records created by perpetrators and witnesses of violent crime are increasingly used as evidence in criminal investigations and court proceedings. When these records include the sexual assault, torture, and murder of individuals, they carry significant power to harm those exposed to them, but most importantly, through repeated viewing, they continue to harm those individuals whose suffering is immortalized therein. Using case study methods, including in-depth interviews with those centrally involved in the case, interviews with criminal justice professionals currently working with video evidence of violent crime, and a review of official documents and media reports, this article examines the tragic Canadian case of serial killers Paul Bernardo and Karla Homolka and the videos they recorded of their crimes. We observe that challenging decisions regarding the handling of video records of violent crime during the investigation process, the viewing of such records in court, and access to them by the public and press during the criminal justice process continue to be areas of concern and contestation, pitting principles of open justice against those of victim dignity and privacy. However, challenges regarding access to video records do not end with a trial and an ultimate verdict of guilt or innocence; rather, decisions continue to be made about the preservation or destruction, the storing and cataloguing, and access to archived material. In examining questions regarding the preservation and continued use of the records, we conclude that a responsible and ethical approach to these challenges is best achieved through what Caswell called a survivor-centred approach. We suggest that this approach should include recognizing the traumatic potentiality of records, providing safety and support to those affected, recognizing the potential of records to produce and perpetuate injustice, respecting the autonomy and decisions of survivors, and accepting and facilitating the right to be forgotten.
Transferred, Preserved, and Destroyed
Authors: Eyford Ryan
Published: April 2024

During the 1950s, the Province of Manitoba microfilmed and then destroyed thousands of files created by the federal Department of the Interior’s Dominion Lands Branch (DLB). These records, dating from about 1870 to 1930, were transferred from the federal government to the province in the immediate post-war period. They were drawn from a group of more than 5.6 million files occupying 11,640 square feet of office space in downtown Ottawa. During the Second World War, the civil servants responsible for the DLB files were pressured by their superiors to destroy the files in order to free up space and filing cabinets. DLB officials, although not trained archivists, took their responsibility as custodians of the records seriously and sought to prevent the wholesale and indiscriminate destruction of the files. They were supported by archivists who considered the DLB files to be valuable historical documents on the colonization of Western Canada. Eventually, the conflict between preservation and destruction was resolved by dispersing the records; some were transferred to the western provinces and territories, while the remaining files were deposited in the Public Archives of Canada. The first files to be transferred were those related to lands in Manitoba. This article clarifies the provenance of the DLB’s Manitoba files and argues for their enduring value as records of the history of settler colonialism in the province while also revealing the role of non-archivist civil servants as custodians of government records in the mid- 20th century.
Nitric oxide production inhibitors from Polygonum multiflorum
Authors: To Dao-Cuong , Nguyen Phi-Hung , Hoang Viet Dung , Hoang Le Minh , Nguyen Hoa Thi , Hoa Truong Thi Viet , Nhung Truong Thi Thuy , Truong Phu Chi Hieu , Van Kim Thuong Pham
Published: April 2024

This study focuses on the anti-inflammatory activity-guided fractionation of the root of Vietnamese Polygonum multiflorum, resulting in the isolation of ten compounds (1–10). These compounds were identified as trans-resveratrol (1), methyl protocatechuate (2), methyl gallate (3), catechin (4), epicatechin (5), 4,6-dihydroxy-2-O-(β- D-glucopyranosyl)acetophenone (6), quercetin (7), apigenin (8), luteolin (9), and tricin (10). Compounds 2, 3, and 6 were isolated from P. multiflorum for the first time. All isolated compounds were tested against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW264.7 cells to assess their anti-inflammatory potential. In vitro results revealed that compounds 7−9 exhibited significant NO production inhibition, with IC50 values of 12.0 ± 0.8, 17.8 ± 0.6, and 7.6 ± 0.3 μM, respectively. N(G)-monomethyl L-arginine (L-NMMA), a positive inhibitor, also effectively reduced LPS-induced NO production, with an IC50 value of 22.1 ± 0.1 μM. These findings indicate that compounds 7−9 isolated from P. multiflorum hold promise for further research and development of anti-inflammatory agents
De quem é esse corpo? A performatividade do gênero feminino no teatro contemporâneo – cruzamentos entre processos criativos das mulheres, cena e gênero
Authors: Romano Lúcia Regina Vieira
Published: April 2024

Esta obra analisa a criação teatral contemporânea das mulheres e questiona a caracterização dessa produção a partir do recorte de gênero feminino. A partir dos termos teatro feminino, teatro da mulher e teatro feminista, Lúcia Romano aponta as implicações deles na crítica e na prática teatrais, na cena nacional e internacional, e a necessidade de revisão dessa terminologia. A autora ressalta a atual multiplicidade de estratégias e poéticas particulares do teatro feito por mulheres, em especial, nas atuações de algumas performers, das atrizes criadoras integrantes do OdinTeatret e da rede internacional Magdalena Project. Observa ainda o progresso do teatro feminista internacional, nas criações dos teatros lésbico, feminista negro e multicultural. Para iluminar o complexo cruzamento entre corporeidade, processos criativos e subjetivação, a autora propõe a constituição de imagens encarnadas, em que a consciência de gênero gera corporeidades específicas na cena, e a análise do corpo sexuado, no processo de comunicação teatral. Por fim, projeta um teatro do andrógino, afeito à subversão de concepções binárias e capaz de encorpar a instabilidade das performances de gênero.
DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
Authors: Mullen Nicholas J. , Shukla Surendra K. , Thakur Ravi , Kollala Sai Sundeep , Wang Dezhen , Chaika Nina , Santana Juan F. , Miklavcic William R. , LaBreck Drew A. , Mallareddy Jayapal Reddy , Price David H. , Natarajan Amarnath , Mehla Kamiya , Sykes David B. , Hollingsworth Michael A. , Singh Pankaj K.
Published: April 2024

Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzyme in the de novo pyrimidine biosynthesis pathway that can be targeted by clinically approved inhibitors. However, despite robust preclinical anticancer efficacy, DHODH inhibitors have shown limited single-agent activity in phase 1 and 2 clinical trials. Therefore, novel combination therapy strategies are necessary to realize the potential of these drugs. To search for therapeutic vulnerabilities induced by DHODH inhibition, we examined gene expression changes in cancer cells treated with the potent and selective DHODH inhibitor brequinar (BQ). This revealed that BQ treatment causes upregulation of antigen presentation pathway genes and cell surface MHC class I expression. Mechanistic studies showed that this effect is 1) strictly dependent on pyrimidine nucleotide depletion, 2) independent of canonical antigen presentation pathway transcriptional regulators, and 3) mediated by RNA polymerase II elongation control by positive transcription elongation factor B (P-TEFb). Furthermore, BQ showed impressive single-agent efficacy in the immunocompetent B16F10 melanoma model, and combination treatment with BQ and dual immune checkpoint blockade (anti-CTLA-4 plus anti-PD-1) significantly prolonged mouse survival compared to either therapy alone. Our results have important implications for the clinical development of DHODH inhibitors and provide a rationale for combination therapy with BQ and immune checkpoint blockade.
Essential Function of Transmembrane Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans Development
Authors: Xu Zhimin , Wang Zhao , Wang Lifang , Qi Yingchuan B.
Published: April 2024

Precise developmental timing control is essential for organism formation and function, but its mechanisms are unclear. In
C. elegans
, the microRNA
lin-4
critically regulates developmental timing by post-transcriptionally downregulating the larval-stage-fate controller LIN-14. However, the mechanisms triggering the activation of
lin-4
expression toward the end of the first larval stage remain unknown. We demonstrate that the transmembrane transcription factor MYRF-1 is necessary for
lin-4
activation. MYRF-1 is initially localized on the cell membrane, and its increased cleavage and nuclear accumulation coincide with
lin-4
expression timing. MYRF-1 regulates
lin-4
expression cell-autonomously and hyperactive MYRF-1 can prematurely drive
lin-4
expression in embryos and young first-stage larvae. The tandem
lin-4
promoter DNA recruits MYRF-1
GFP
to form visible loci in the nucleus, suggesting that MYRF-1 directly binds to the
lin-4
promoter. Our findings identify a crucial link in understanding developmental timing regulation and establish MYRF-1 as a key regulator of
lin-4
expression.