bluuebunny/crossref_metadata_2025 huggingface dataset:
Representaciones socio-espaciales (Toporepresentaciones) de Bogotá: perspectivas de la (in)seguridad
Authors: Avendaño Arias Johan Andrés
Published: October 2017

Este artículo aporta en los procesos comprensivos de construcción de las representaciones socio-espaciales o toporrepresentaciones. Para ello, se toma como caso de estudio la ciudad de Bogotá, Colombia; se cuestiona la instrumentalización dada a cierto tipo de herramientas cartográficas, que usufructuando su potencialidad comunicativa, se han constituido en dispositivos de afianzamiento de sistemas de interpretación hegemónicos; se recurre al análisis de mapas oficiales sobre delincuencia, para contrastarlos con espacializaciones subjetivas –mapas mentales– elaboradas por residentes de Bogotá. Así, se llega a delimitar algunos tipos de toporrepresentaciones de (in)seguridad (valoraciones y significados), y sus impactos en la forma de llevar la experiencia espacial, como también de construir la relación misma con la ciudad. Las ciudades latinoamericanas, en un crisol de imaginarios provenientes de diversas latitudes, han sido tipificadas recientemente como urbes peligrosas e inseguras; estas representaciones espaciales han propiciado la búsqueda de relaciones causales simplistas y deterministas por predilección.
Ciudadanía activa y la transición a la adultez en México
Authors: Mora Minor , Urbina Cortés Gustavo A.
Published: October 2017

En este artículo se analiza la asociación entre procesos vitales y políticos, mediante un balance general del tratamiento bibliográfico del compromiso cívico y la transición a la adultez. A través de técnicas de análisis estadístico y sociodemográfico, se ejemplifica la conformación de un patrón de dependencia temporal, donde oportunidades desiguales de involucramiento cívico derivan de la tenencia de ciertos atributos socioeconómicos. También se ejemplifican la antecedencia socio-política familiar, la precedencia de experiencias asociativas durante la infancia; así como eventos y circunstancias específicos que tienen lugar durante el periodo que corre desde la niñez de los sujetos hasta el momento en que adquieren la mayoría de edad.
Variability of pterygoid teeth in three species of Podarcis lizards and the utility of palatal dentition in lizard systematics
Authors: Skawiński Tomasz , Borczyk Bartosz , Turniak Edyta
Published: October 2017

Palatal dentition in lizards is incompletely known, especially data on its variability are scarce. We studied variation in the number of pterygoid teeth in three species of Podarcis, a species-rich genus of lacertid lizards: terrestrial, P. siculus and saxicolous, P. erhardii and P. cretensis. In contrast to some previous studies, we found no sexual dimorphism in the number of palatal teeth in any of these species. The number of teeth was not correlated to lizard size. In our sample, P. cretensis on average had more teeth than did P. erhardii but fewer than did P. siculus. In addition, some specimens of P. cretensis and P. siculus showed asymmetry in the number of pterygoid teeth, which may be a result of anthropogenic pressure. The observed variability in the occurrence of palatal dentition illustrates the importance of scoring this character in phylogenetic analyses only on the basis of a sufficient sample.
Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017
Authors: Terkelsen David , Tolstrup Jacob , Johnsen Camilla Hundahl , Lund Ole , Larsen Helle Kiellberg , Worning Peder , Unemo Magnus , Westh Henrik
Published: October 2017

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.
Self-Inflicted Orbito-Cranial Injury Secondary to Gunshot: Case Report
Authors: Roka Yam Bahadur , Bhattarai Narayani Roka
Published: October 2017

The eye may be injured by various penetrating and non-penetrating injuries like sticks, pencils, rods, gunshot and chopsticks. Self-inflicted gunshot injuries have been rarely reported in literature. This case is interesting in multiple aspects which include poverty, lack of education and the failure of government to ensure control of the use of firearms in Nepal. We report a case of self-inflicted gun injury which was managed successfully.
Photometric and Polarimetric Interpretation of Blazar AO 0235+164 Behaviour
Authors: Shablovinskaya Elena
Published: October 2017

Among the great number of controversial issues, the most topical one both for theoretical and observational astrophysics presently is a problem of active galactic nuclei investigation. To explain the behaviour of blazar AO 0235+164, which has been under observation at the LX200 telescope (SPbSU) since 2002, the method of analyzing developed by V.A. Hagen-Thorn and S.G. Marchenko was applied. It is based on the assumption that in the case of observational data lying on the straight line in the absolute Stokes parameters space { I , Q , U } (for polarimetry) and the fluxes space { F 1 , . . F n } (for photometry), relative Stokes parameters and relative flux ratios stay unchanged , and consequently, only one source is corresponding to the variability of general value of flux. In this paper, the photometric and polarimetric interpretation of blazar behaviour is presented. Furthermore, the flux and flux–flux diagrams are obtained for three periods of object monitoring: 2006–2007 and 2008–2009 (outbursts) and 2009–2016 (decline with 2015 outburst).
A Field-Theoretical Approach to the P vs. NP Problem via the Phase Sign of Quantum Monte Carlo
Authors: Patrascu Andrei
Published: October 2017

I present here a new method that allows the introduction of a discrete auxiliary symmetry in a theory in such a way that the eigenvalue spectrum of the fermion functional determinant is made up of complex conjugated pairs. The method implies a particular way of introducing and integrating over auxiliary fields related to a set of artificial shift symmetries. Gauge fixing the artificial continuous shift symmetries in the direct and dual sectors leads to the appearance of direct and dual Becchi–Rouet–Stora–Tyutin (BRST)-type global symmetries and of a symplectic structure over the field space. Such a method may allow the extension of the applicability of quantum Monte Carlo methods to some problems plagued by the fermionic sign problem.
A Method for the Realization of an Interruption Generator Based on Voltage Source Converters
Authors: Li Junhui , Zhang Tianyang , Qi Lei , Yan Gangui
Published: October 2017

In this paper we described the structure and working principle of an interruption generator based on voltage source converters (VSCs). The main circuit parameters of the VSCs are determined according to the target of power transfer capability, harmonic suppression, and dynamic response capability. A state feedback linearization method in nonlinear differential geometry theory was used for dq axis current decoupling, based on the mathematical model used in the dq coordinate system of VSCs. The direct current control strategy was adopted to achieve the independent regulation of active power and reactive power. The proportional integral (PI) link was used to optimize the dynamic performance of the controller, and PI parameters were adjusted. Disturbance voltage waves were generated by the regular sampling method. PSCAD/EMTDC simulation results and physical prototype experiments showed that the device could generate various disturbance voltage waveforms steadily, and had good dynamic and steady-state performance.
Hydration Phenomena of Functionalized Carbon Nanotubes (CNT)/Cement Composites
Authors: Balasubramaniam Bhuvaneshwari , Mondal Kunal , Ramasamy Karunya , Palani Gadyam S. , Iyer Nagesh R.
Published: October 2017

The exciting features of carbon nanotubes (CNTs), such as high elastic modulus, high thermal and electrical conductivities, robustness, and nanoscopic surface properties make them attractive candidates for the cement industry. They have the potential to significantly enhanceengineering properties. CNTs play an important and critical role as nano-anchors in concrete, which enhance the strength by bridging pores in the composite matrix, thereby ensuring robust mechanical strength. The diameter, dispersion, aspect ratio, and interfacial surface interaction of CNTs affect the physical and mechanical properties of concrete, if due care is not taken. In this paper, the usable amount of CNT is scaled down considerably from 0.5% to 0.025% by weight of the cement and the fluctuation caused by these phenomena is assessed. It is observed that the properties and exact quantities of incorporated CNTs influence the hydration and consistency of the composites. In order to address these issues, the surface functionalization of CNTs and rheological studies of the composites are performed. The hydration products and functional groups are carefully optimized and characterized by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and a Zeta potential analyzer. For Mixes 6 and 7, the compressive and tensile strength of CNTs incorporated in mortar specimens caused77% and 48% increases in split tensile strength, respectively, and 17% and 35% increases in compressive strength, respectively, after 28 days of curing and compared withthe control Mix.
Properties of Water Bound in Hydrogels
Authors: Gun’ko Vladimir , Savina Irina , Mikhalovsky Sergey
Published: October 2017

In this review, the importance of water in hydrogel (HG) properties and structure is analyzed. A variety of methods such as 1H NMR (nuclear magnetic resonance), DSC (differential scanning calorimetry), XRD (X-ray powder diffraction), dielectric relaxation spectroscopy, thermally stimulated depolarization current, quasi-elastic neutron scattering, rheometry, diffusion, adsorption, infrared spectroscopy are used to study water in HG. The state of HG water is rather non-uniform. According to thermodynamic features of water in HG, some of it is non-freezing and strongly bound, another fraction is freezing and weakly bound, and the third fraction is non-bound, free water freezing at 0 °C. According to structural features of water in HG, it can be divided into two fractions with strongly associated and weakly associated waters. The properties of the water in HG depend also on the amounts and types of solutes, pH, salinity, structural features of HG functionalities.
Paid Sick Leave and Risks of All-Cause and Cause-Specific Mortality among Adult Workers in the USA
Authors: Kim Daniel
Published: October 2017

Background: The USA is one of only a few advanced economies globally that does not guarantee its workers paid sick leave. While there are plausible reasons why paid sick leave may be linked to mortality, little is known empirically about this association. Methods: In a pooled USA nationally-representative longitudinal sample of 57,323 working adults aged 18–85 years from the National Health Interview Surveys 2000–2002, paid sick leave was examined as a predictor of all-cause and cause-specific mortality. Multivariate Cox proportional hazards models were used to estimate the impact of paid sick leave on mortality. Results: Having paid sick leave through one’s job was associated with 10% (hazards ratio, HR = 0.90; 95% CI = 0.81–0.996; p = 0.04), 14% (HR = 0.86; 95% CI = 0.74–0.99; p = 0.04), and 22% (HR = 0.78; 95% CI = 0.65–0.94; p = 0.01) significantly lower hazards of all-cause mortality after mean follow-up times of 11.1, 6.5, and 4.5 years, respectively. This study further identified associations of paid sick leave with 24% (HR = 0.76; 95% CI = 0.59–0.98; p = 0.03), and 35% (HR = 0.65; 95% CI = 0.44–0.95; p = 0.03) lower hazards of dying from heart diseases and unintentional injuries, respectively. Conclusions: To the author’s knowledge, this study provides the first empirical evidence on the linkages between paid sick leave and mortality and supports protective effects, particularly against heart diseases and unintentional injuries. The most salient association corresponded to a lag period of just less than five years. Social policies that mandate paid sick leave may help to reduce health inequities and alleviate the population burden of mortality among working adults in the USA.
Correlation Analysis of PM10 and the Incidence of Lung Cancer in Nanchang, China
Authors: Zhou Yi , Li Lianshui , Hu Lei
Published: October 2017

Air pollution and lung cancer are closely related. In 2013, the World Health Organization listed outdoor air pollution as carcinogenic and regarded it as the most widespread carcinogen that humans are currently exposed to. Here, grey correlation and data envelopment analysis methods are used to determine the pollution factors causing lung cancer among residents in Nanchang, China, and identify population segments which are more susceptible to air pollution. This study shows that particulate matter with particle sizes below 10 micron (PM10) is most closely related to the incidence of lung cancer among air pollution factors including annual mean concentrations of SO2, NO2, PM10, annual haze days, and annual mean Air Pollution Index/Air Quality Index (API/AQI). Air pollution has a greater impact on urban inhabitants as compared to rural inhabitants. When gender differences are considered, women are more likely to develop lung cancer due to air pollution. Smokers are more likely to suffer from lung cancer. These results provide a reference for the government to formulate policies to reduce air pollutant emissions and strengthen anti-smoking measures.
An Interactive Planning Support Tool for Addressing Social Acceptance of Renewable Energy Projects in The Netherlands
Authors: Flacke Johannes , De Boer Cheryl
Published: October 2017

The implementation of renewable energy policies is lagging behind in The Netherlands. While several Dutch cities have ambitious goals for reducing greenhouse gas (GHG) emissions, the implementation of renewable energy projects has been rather slow. The main reasons for this are the limited institutional capacities of local decision-makers, low levels of social acceptance of renewable-energy technologies, and limited opportunities for engagement of communities in decision-making processes. In order to address these issues we have developed an interactive planning support tool named COLLAGE for stakeholder participation in local renewable-energy planning. The goal of this paper is to analyze whether the COLLAGE tool helps to increase community engagement in renewable-energy projects and planning by increasing awareness and addressing social learning issues related to renewable-energy options. We tested the tool in a series of workshops with stakeholders and citizens from the city of Enschede, The Netherlands. The workshop results show that the tool helped involve stakeholders and communities in deciding where to locate renewable-energy facilities. It increased community members’ awareness of the benefits of and requirements for renewable energy by disclosing the spatial consequences of overall municipal goals. We conclude that the COLLAGE tool can be an important building block towards new local energy governance.
Impacts of Modification of Alloying Method on Inclusion Evolution in RH Refining of Silicon Steel
Authors: Li Fangjie , Li Huigai , Zheng Shaobo , You Jinglin , Han Ke , Zhai Qijie
Published: October 2017

This study explores the effect of introducing additional alloy elements not only in a different order but also at different stages of the Ruhrstahl-Heraeus (RH) process of low-carbon silicon steel production. A more economical method, described as “pre-alloying”, has been introduced. The evolution of MnO-FeO inclusions produced by pre-alloying was investigated. Results show that spherical 3FeO·MnO inclusions form first, then shelled FeO·zMnO (z = 0.7–4) inclusions nucleate on the surface of pre-existing 3FeO·MnO. Spherical FeO·zMnO (z = 3–5) is further evolved from shelled 3FeO·MnO by diffusion. Because these MnO-FeO inclusions float up into the slag before degassing, the pre-alloying process does not affect the quality of the melt in the end. Both carbon content and inclusion size conform to industry standards.
Lipase-Catalyzed Transesterification of Egg-Yolk Phophatidylcholine with Concentrate of n-3 Polyunsaturated Fatty Acids from Cod Liver Oil
Authors: Chojnacka Anna , Gładkowski Witold , Grudniewska Aleksandra
Published: October 2017

Phospholipids containing PUFAs are important vehicles for their delivering to the targeted tissues. In our research project we established enzymatic methods for the enrichment of natural egg-yolk PC with n-3 PUFAs. Instead of synthetic PUFA ethyl esters, the new strategy was developed using polyunsaturated fatty acids enriched fraction (PUFA-EF) from cod liver oil as the natural acyl donors. PUFA-EF was produced by urea-complexation and contained 86.9% PUFA including 8.5% stearidonic acid (SDA; 18:4(n-3)), 26.7% EPA, and 45.2% DHA. The transesterification of PC with PUFA was catalyzed by lipases. After screening of enzymes the effect of reaction medium; molar ratio of substrates and etc. was investigated. The highest incorporation of PUFA was 45.6%; including 36.8% DHA and 5.8% EPA at the following reaction conditions: hexane; 55 °C; PUFA-EF/PC acyl ratio of 10; 48 h of reaction time and lipase B from Candida antarctica as a biocatalyst (20% of enzyme load).
High Fat Diet with a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters
Authors: Yang Suh-Ching , Lin Shyh-Hsiang , Chang Jung-Su , Chien Yi-Wen
Published: October 2017

The aim of this study was to investigate the effect of a high fat diet with experimental oil consisting of 60% MUFAs (monounsaturated fatty acids) with a P/S ratio of 5 on fat deposition and lipid metabolism in obese hamsters. Hamsters were randomly assigned to a control group and a diet-induced obesity group for nine weeks. Then an additional eight-week experimental period began, during which obese hamsters were randomly divided into three groups and fed different amounts of the experimental oil mixture in their diets as follows: 5%, 15%, and 20% w/w (OB-M5, OB-M15, and OB-M20 groups, respectively). The results showed that the OB-M15 and OB-M20 groups had significantly lower blood cholesterol and higher insulin levels. Compared to the control group, the three obese groups exhibited higher hepatic fatty acid synthase activity; however, the acyl-CoA oxidase activities were also enhanced. Although dietary fat content differed, there were no differences in energy intake, final body weights, and epididymal fat weights among the four groups. These results suggest that regardless of whether the specimens had a high fat intake or not, dietary fat containing high MUFAs with a high P/S ratio had beneficial effects on maintaining blood lipid profiles and may not result in body fat accumulation in obese hamsters, possibly by promoting lipolytic enzyme activities.
Morphology, Crystallization and Thermal Behaviors of PLA-Based Composites: Wonderful Effects of Hybrid GO/PEG via Dynamic Impregnating
Authors: Jia Shikui , Yu Demei , Zhu Yan , Wang Zhong , Chen Ligui , Fu Lei
Published: October 2017

In this paper, a dynamic impregnating device, which can generate supersonic vibration with the vacuum-adsorbing field, was used to prepare the hybrid graphene oxide (GO)/polyethylene glycol (PEG). Interestingly, the hybrid GO/PEG under dynamic impregnating and/or internal mixing was introduced into poly-(lactic acid) (PLA) matrix via melting-compounding, respectively. On one hand, compared with the internal mixing, the hybrid GO/PEG with the different component ratio using dynamic impregnation had a better dispersed morphology in the PLA matrix. On the other hand, compared with the high molecular weight (Mw) of PEG, the hybrid GO/PEG with low Mw of PEG had better an exfoliated morphology and significantly improved the heat distortion temperature (HDT) of the PLA matrix. Binding energies results indicate that low Mw of PEG with GO has excellent compatibility. Dispersed morphologies of the hybrid GO/PEG show that the dynamic impregnating had stronger blending capacity than the internal mixing and obviously improved the exfoliated morphology of GO in the PLA. Crystallization behaviors indicate that the hybrid GO/PEG with the low Mw of PEG based on dynamic impregnating effectively enhanced the crystallinity of PLA, and the cold crystallization character of PLA disappeared in the melting process. Moreover, the storage modulus and loss factor of the PLA-based composites were also investigated and their HDT was improved with the introduction of hybrid GO/PEG. Furthermore, a physical model for the dispersed morphology of the hybrid GO/PEG in the PLA matrix was established. Overall, the unique blending technique of hybrid GO/PEG via dynamic impregnating is an effective approach to enhance the property range of PLA and is suitable for many industrial applications.
Downhole Applications of Magnetic Sensors
Authors: Gooneratne Chinthaka , Li Bodong , Moellendick Timothy
Published: October 2017

In this paper we present a review of the application of two types of magnetic sensors—fluxgate magnetometers and nuclear magnetic resonance (NMR) sensors—in the oil/gas industry. These magnetic sensors play a critical role in drilling wells safely, accurately and efficiently into a target reservoir zone by providing directional data of the well and acquiring information about the surrounding geological formations. Research into magnetic sensors for oil/gas drilling has not been explored by researchers to the same extent as other applications, such as biomedical, magnetic storage and automotive/aerospace applications. Therefore, this paper aims to serve as an opportunity for researchers to truly understand how magnetic sensors can be used in a downhole environment and to provide fertile ground for research and development in this area. A look ahead, discussing other magnetic sensor technologies that can potentially be used in the oil/gas industry is presented, and what is still needed in order deploy them in the field is also addressed.
The Role of Cultural Heritage in Sustainable Development: Multidimensional Indicators as Decision-Making Tool
Authors: Nocca Francesca
Published: October 2017

The concept of sustainable development has been the main topic of many international conferences. Although many discussions are related to the role of cultural heritage in sustainable development, they develop only on theoretical level. The answer to the main question, that is if the cultural landscape can play a role in sustainable development, could be positive only if we are able to produce empirical evidence about its contribution to improve economic, social, and environmental productivity of the city. It is necessary to produce empirical evidence to demonstrate that cultural heritage conservation/valorization is an investment and not a cost. To date, there are few researches about the indicators that are able to support the relationship between cultural heritage conservation/regeneration and sustainable development. This paper intends to go beyond this limit and approach this issue in operational terms. It is focused on the role that cultural heritage can play in the sustainable development framework. An assessment framework that is able to capture the multidimensional benefits of cultural landscape conservation/valorization is proposed here starting from the analysis of 40 case studies of culture-led regeneration projects. A matrix of multidimensional indicators (divided into nine categories) about the impacts produced by these 40 cultural heritage conservation/valorization projects and its critical analysis is here proposed, mainly focusing the attention on the double relationship between the tourism sector and climate change. Although the analyses often refer to sustainability, it is not concretely addressed because there is an imbalance among the dimensions: in most cases, only the economic component is highlighted, leaving out the social and environmental dimensions. Furthermore, the impacts related to cultural-led projects are mainly interpreted in terms of tourism and real estate impacts.
A Retinal Vessel Detection Approach Based on Shearlet Transform and Indeterminacy Filtering on Fundus Images
Authors: Guo Yanhui , Budak Ümit , Şengür Abdulkadir , Smarandache Florentin
Published: October 2017

A fundus image is an effective tool for ophthalmologists studying eye diseases. Retinal vessel detection is a significant task in the identification of retinal disease regions. This study presents a retinal vessel detection approach using shearlet transform and indeterminacy filtering. The fundus image’s green channel is mapped in the neutrosophic domain via shearlet transform. The neutrosophic domain images are then filtered with an indeterminacy filter to reduce the indeterminacy information. A neural network classifier is employed to identify the pixels whose inputs are the features in neutrosophic images. The proposed approach is tested on two datasets, and a receiver operating characteristic curve and the area under the curve are employed to evaluate experimental results quantitatively. The area under the curve values are 0.9476 and 0.9469 for each dataset respectively, and 0.9439 for both datasets. The comparison with the other algorithms also illustrates that the proposed method yields the highest evaluation measurement value and demonstrates the efficiency and accuracy of the proposed method.
P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes
Authors: Schwiering Markus , Husmann Matthias , Hellmann Nadja
Published: October 2017

The pore forming hemolysin A, Hla, is a major virulence factor of Staphylococcus aureus. Apparently, 1–2 pore(s) per cell suffice(s) to cause cell death. Accumulated experimental evidence points towards a major role of ATP-gated purinergic receptors (P2XR) for hemolysis caused by Hla, complement and other pore forming proteins, presumably by increasing membrane permeability. Indeed, in experiments employing rabbit erythrocytes, inhibitory concentrations of frequently employed P2XR-antagonists were in a similar range as previously reported for erythrocytes of other species and other toxins. However, Hla-dependent hemolysis was not enhanced by extracellular ATP, and oxidized adenosinetriphosphate (oxATP) had only a minor inhibitory effect. Unexpectedly, P2XR-inhibitors also prevented Hla-induced lysis of pure lipid membranes, demonstrating that the inhibition did not even depend on the presence of P2XR. Fluorescence microscopy and gel-electrophoresis clearly revealed that P2XR-inhibitors interfere with binding and subsequent oligomerisation of Hla with membranes. Similar results were obtained employing HaCaT-cells. Furthermore, calorimetric data and hemolysis experiments with Hla pre-treated with pyridoxal phosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS) showed that this compound directly binds to Hla. Our results call for a critical re-assessment of the appealing concept, which suggests that P2XR are general amplifiers of damage by pore-forming proteins.
Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration
Authors: Zhang Qun , Su Ruixia , Shan Chun , Gao Chao , Wu Pei
Published: October 2017

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here
we identified NCAPG (non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset. We found that knockdown of NCAPG induces
HCC cell mitosis and inhibits cell growth, proliferation, and migration in vitro. Tetracycline-inducible shRNA knockdown of NCAPG inhibits tumor growth of HCC cells in vivo. Moreover, overexpression of NCAPG in clinical HCC samples was associated with recurrence and survival of patients. The
overexpression of NCAPG was significantly correlated with the overexpression of CCNB1 (G2/mitotic-specific cyclin B1), a regulatory protein involved in mitosis. Therefore, NCAPG may provide a promising novel therapeutic target for the treatment of advanced HCC in the future.
Long-Term Use of Nimotuzumab in Combination With Intensity-Modulated Radiotherapy and Chemotherapy in the Treatment of Locoregionally Advanced Nasopharyngeal Carcinoma: Experience of a Single Institution
Authors: Fangzheng Wang , Chuner Jiang , Zhiming Ye , Tongxin Liu , Fengqin Yan , Lei Wang , Bin Li , Fujun Hu , Ming Chen , Weifeng Qin , Zhenfu Fu
Published: October 2017

In this retrospective review of a single institution’s experience, the efficacy and safety of the long-term use of nimotuzumab in combination with intensity-modulated radiotherapy (IMRT) and chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma (NPC) were
studied. Between August 2008 and March 2014, 39 newly diagnosed patients with stages III‐IV NPC were treated with IMRT, chemotherapy, and nimotuzumab. Twenty patients were diagnosed with stage III (51.3%), 14 with stage IVA (35.9%), and 5 with stage IVB (12.8%) disease. All patients
received at least one cycle of cisplatin-based induction chemotherapy followed by IMRT and more than nine cycles of nimotuzumab at 200 mg/week. Acute and late radiation-related toxicities were graded according to the Acute and Late Radiation Morbidity Scoring Criteria of the Radiation Therapy
Oncology Group. Accumulated survival was calculated according to the Kaplan‐Meier method. The log-rank test was used to compare survival differences. With a median follow-up of 46 months (range, 22‐86 months), the estimated 3-year local recurrence-free, regional recurrence-free,
distant metastasis-free, progression failure-free, and overall survival rates were 92.1%, 89.7%, 82.5%, 77.6%, and 86.8%, respectively. Univariate analysis showed that clinical stage and the cycle of induction chemotherapy were related with prognosis. The median cycle for the addition of nimotuzumab
was 12 weeks. Grade 3 radiation-induced mucositis was observed in 15.8% of the treated patients. No skin rash or infusion reaction was observed, which is distinctly different from what was reported in patients treated with nimotuzumab. The major toxicities observed were grades I‐II
mucositis and leukocytopenia. Long-term use of nimotuzumab plus IMRT showed promising outcomes in terms of locoregional control and survival, without increasing the incidence of radiation-related toxicities in patients.
A Field Takes Stock: Papers From The 8th International Congress On Coastal And Marine Tourism
Authors: Miller Marc L. , Auyong Jan , Szuster Brian W. , Needham Mark D. , Orams Mark B. , Wilks Jeff , Lück Michael
Published: October 2017

Humans are transforming the coastal and marine tourism environment at an ever-increasing rate. Concurrently, the multiple amenities and natural resources of coastal zones and the reality of population growth contribute to omnipresent tourism user conflicts. This results in social, wicked,
and super wicked problems that are value infused, difficult to frame, and seemingly intractable. In response, scientists and other experts are encouraged to engage in use-inspired research. Further, they are advised to reconsider the basic applied science dichotomy and to make policy contributions
in the role of the honest broker. Articles from the 8th International Congress on Coastal and Marine Tourism are introduced that deal with tsunami vulnerability (Thailand), wreck diving (Australia/Micronesia), national forest planning (Gulf of Alaska), cruise industry research, aquatic
safety (Australia), surfing expansion (South Africa), stakeholder relations (Zanzibar, Tanzania), and kiteboarding (the Netherlands).
Using genomic data to develop chloroplast DNA SSRs for the Neotropical liana Stizophyllum riparium (Bignonieae, Bignoniaceae)1
Authors: Beyer Maila , Nazareno Alison G. , Lohmann Lúcia G.
Published: October 2017

Premise of the study:

We developed chloroplast microsatellite markers (cpSSRs) to be used to study the patterns of genetic structure and genetic diversity of populations of Stizophyllum riparium (Bignonieae, Bignoniaceae).

Methods and Results:

We used genomic data obtained through an Illumina HiSeq sequencing platform to develop a set of cpSSRs for S. riparium. A total of 36 primer pairs were developed, of which 28 displayed polymorphisms across 59 individuals from three populations. Two to 12 alleles were recorded, and the unbiased haploid diversity per locus ranged from 0.037 to 0.905. All 28 cpSSRs presented transferability to two closely related species, S. inaequilaterum and S. perforatum.

Conclusions:

We report a set of 28 cpSSRs for S. riparium. All markers were shown to be variable in S. riparium, indicating that these markers will be valuable for population genetic studies across S. riparium and congeneric species.
A mechanochemical approach to access the proline–proline diketopiperazine framework
Authors: Pétry Nicolas , Benakki Hafid , Clot Eric , Retailleau Pascal , Guenoun Farhate , Asserar Fatima , Sekkat Chakib , Métro Thomas-Xavier , Martinez Jean , Lamaty Frédéric
Published: October 2017

Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptides under solvent-free conditions. A deprotection–cyclization sequence yielded the corresponding diketopiperazines that were obtained with a high stereoselectivity which could be explained by DFT calculations. Using this method, an enantiopure disubstituted Pro–Pro diketopiperazine was synthesized in 4 steps, making 5 new bonds using a ball mill.
Attending home care patients in primary care using a smartphone application (WhatsICS): A feasibility study
Authors: Marin-Gomez Francesc X. , Vidal-Alaball Josep , Garcia Cuyàs Francesc , Reig-Bolano Ramon
Published: October 2017

Background: Provision of care to patients with chronic diseases at their homes remains a great challenge for modern health care systems. Smartphone applications are indicated as one of the strategies that could improve care delivery to this group of patients. The aim of this study is to investigate the feasibility and usability of a proprietary application with a messaging service used by a primary care team attending chronic patients mainly at their homes.
Methods: A Cross-sectional pilot study of a smartphone application to communicate amongst clinicians. Primary care practices in Tona, Spain, were recruited during a period from January to December 2016. Clinicians used WhatsICS to communicate during their home visits for 12 months. We studied the patterns of use, response time and types of communication. To explore barriers and enablers, semi-structured interviews were conducted with selected nurses, social worker and general practitioners.
Results: Two nurses, two practitioners and a social worker were recruited and more than 1,000 hours of communication were recorded on 163 patients, generating 5820 communication events. Nurses initiated the majority of communications (59.79%); these communications were mainly for the purpose of receiving instructions from practitioners and for coordination (66.6%). The communications were made on weekdays, from Monday to Friday, and between 7:30 a.m. and 9:30 p.m. (99.73%). Participants felt that WhatsICS helped streamline and improve home-based care.
Conclusions: WhatsICS is safe technologically and accepted as a communication tool for professionals. This study establishes the basis for future implementations of this tool to improve the care of chronic patients at home through smartphones.
L’exil de l’exilé
Authors: Goldschmidt Georges-Arthur
Published: October 2017

Arrimé à sa propre expérience, l’auteur évoque le désemparement perceptif, géographique, linguistique, corporel et psychique, de celui qui doit vivre un exil et/ou le subir, ainsi que la difficile et nécessaire reconstruction intérieure exigeant l’intégration d’une nouvelle réalité vécue n’excluant pas le vécu initial.
La femme de Loth, Cary Grant et le rêve américain
Authors: Boulanger Ghislaine , Petiteau Catherine
Published: October 2017

Cet article explore deux dimensions de l’expérience commune à tous les immigrés, qu’ils aient choisi d’immigrer ou que les circonstances extérieures les aient obligés à faire ce choix : la perte d’une continuité contextuelle avec, comme conséquence, le fait d’être un étranger dans la nouvelle culture. En nous appuyant sur la littérature contemporaine traitant des états discontinus de soi multiples, nous proposons l’hypothèse que, pour de nombreux immigrés, des aspects dissociés de leur expérience de soi symbolisent leur culture d’origine. Que ces états dissociés soient idéalisés et ressentis comme inatteignables dans la nouvelle culture, ou dénigrés et rejetés pour tenter d’établir de nouveaux liens, s’ils ne sont pas rendus conscients, examinés, s’il n’en est pas fait le deuil et s’ils ne sont pas réintégrés, l’immigré(e) fera l’expérience d’être lui(elle)-même comme la femme de Loth, changée en une statue de sel, son regard figé pour l’éternité sur le monde perdu. Ou bien, se coupant d’un monde méprisé qu’il a fui, il se coupera lui-même des aspects valables de son expérience de soi oubliés par inadvertance dans l’acte de l’immigration. À partir d’un matériel clinique abondant, nous arrivons à la conclusion qu’être un ou une immigrée n’est pas de l’assimilation, mais un processus d’accommodation mutuelle entre des états du soi qui détiennent des passeports différents.
Le deuil périnatal dans les minorités culturelles
Authors: Gerber Simone
Published: October 2017

Lorsqu’une mère accouche dans un pays très éloigné de sa propre culture, puis vit l’expérience douloureuse d’une maladie grave ou de la perte de son bébé, les soignants sont confrontés à des expériences éprouvantes, tant par la gravité de l’événement que par sa survenue dans un pays d’immigration. La souffrance liée au deuil est universelle. Les soignants, dans l’univers technique contemporain qui risque d’être déshumanisant, se doivent de rester présents auprès des femmes et des familles, malgré les différences culturelles et langagières. Il faut savoir que chaque individu par son histoire familiale, par son cheminement personnel, s’inscrit différemment dans sa culture d’origine, et que les positions individuelles sont beaucoup plus variées qu’on ne l’imagine. Ce qu’il faut surtout comprendre, ce sont les difficultés accumulées par une femme qui doit vivre une grossesse puis la maladie ou la perte d’un bébé loin de sa famille, de ses parents, de son pays. Cette expérience peut néanmoins être mobilisatrice des énergies propres au travail de deuil. Les soignants doivent mesurer combien leurs paroles mais aussi leur présence silencieuse sont aptes à accompagner et à soutenir cette énergie.
L’obéissance
Authors: Bernard David
Published: October 2017

Il s’agira ici de questionner la thèse de Jacques Lacan selon laquelle l’obéissance est toujours conditionnée par le signifiant, et ses effets de jouissance. Il y insista tout au long de son enseignement, ajoutant à cette thèse divers apports successifs à l’appui de son réexamen du statut du signifiant, non seulement dans le langage, mais dans ce qu’il nommera aussi lalangue
Image des femmes et dissolution des problèmes publics. La lutte contre le sexisme dans les médias et la publicité papier en France depuis 1983
Authors: Massei Simon
Published: October 2017

La lutte contre le sexisme dans la publicité et les médias papier constitue depuis les années 1980 une sous-catégorie d’action publique à part entière. Partant de l’échec du projet de loi antisexiste défendu par Yvette Roudy en 1983, cet article identifie trois évolutions majeures dans la politique menée depuis lors : l’autodisciplinarisation des professionnels de la publicité, la reformulation du problème du sexisme dans des termes déconflictualisants, et l’usage de techniques individualisantes.
Characterization of quality recycled gypsum and plasterboard with maximized recycled content
Authors: Jiménez-Rivero A. , García-Navarro J.
Published: October 2017

The quality of secondary materials is imperative to promote a circular economy. In order to improve the way in which the quality of recycled gypsum is assessed, European guidelines on recycled gypsum (RG) quality criteria have been outlined in the framework of the Life+ Gypsum to Gypsum (GtoG) project. Such GtoG guidelines, along with the European Standard on gypsum plasterboard EN 520, provided the basis for this study. During the GtoG project, gypsum recycling and plasterboard manufacturing processes were monitored by testing the gypsum feedstock and the plasterboard produced. The aim of this paper is to discuss the results obtained on relevant parameters that characterize gypsum as a secondary raw material, as well as the resulting product. The minimum requirements were fulfilled by 56% of the RG samples and 86% of the plasterboard with increased RG.
Organisational and Marketing Challenges in Designing and Implementing an Omnichannel Strategy for Luxury Fashion Brands
Authors: Pini Fabrizio Maria , Quaquarelli Barbara
Published: October 2017

The adoption of omnichannel strategies by luxury fashion brands has a relevant impact on the whole value chain and generates many critical organizational implications for luxury companies. The reluctance of several fashion brands in adopting omnichannel initiatives might be related the uniqueness of luxury fashion value proposition, strongly related to rich storytelling and memorable experiences and on the need of large organisation redesign that involve collection design, physical retail role and functions, service design and inventory and supply chain management. There is no common approach to such topics within luxury fashion companies a present but it is possible to draw a sort of “ominchannel adoption curve or life cycle”, with the different evolutionary stages in which companies might be at present. These different stages are characterised by different goals for omnichannel, different level of integration between digital and traditional retail, information generation and sharing and function goals and competencies.
“Exclusivity Dared”
Authors: Mekonnen Aster , Larner Liz
Published: October 2017

While the luxury goods market has been slow to embrace and capitalise on the opportunities related to the digital era that has not been the case for their customers. Fashion luxury brands are no exception to this and some have been noted for their inability to keep up with the digital revolution. In the case of fashion luxury brands, whilst some argue that the offline-online integration has added value to the brands others suggest that it has eroded the panache associated with luxury brand. As luxury fashion brands play a significant role in shaping the fashion industry one cannot ignore the approach to digital integration and the impact it may have on the direction the fashion industry takes. As noted by Michael Porter (2001) whether one should integrate internet technology as part of their business plan is no longer questionable, but rather a matter of how it may be most effectively deployed. Based on case studies this chapter investigates how successful integration of the offline with the online environment can be achieved for such a dynamic industry.
User-Generated Content and Consumer Purchase Intentions in the Cosmetic Industry
Authors: Patel Jemi
Published: October 2017

Online retailers within the luxury cosmetics industry have grown in popularity due to a wider and more diverse catalogue of products. Beauty e-commerce has also seen an uplift due to the increase in blogs/vlogs and online YouTube tutorials which motivate customers to click through to brands and retailer sites through links and affiliate marketing. Given the importance of computer-mediated marketing environments, particularly the burgeoning Internet tapestry along with its various social networking platforms, it is fundamental for management to foster and understand how these emerging technologies impact on their marketing strategies. Drawing on social impact theory (SIT), this paper contends that user-generated content can provide the basis for brand managers in the cosmetic industry to re-evaluate their digital marketing strategies. The paper concludes with discussions about the value of social impact theory in the development of digital marketing strategies.
Luxury Product Decision-Making Strategy
Authors: Bowen Gordon , Bowen Deidre
Published: October 2017

This book chapter suggests that strategic decision making in relation to luxury products needs to include not only cognitive processes, but also emotional attributes. This is because luxury products are heavily linked to affective behaviour, and to differentiate them in the market needs pure competencies, i.e. competencies that are not connected to core competencies, but can be applied to different industries and markets. The chapter further suggests that collaborative working with suitable partners is necessary to develop strategic capabilities that facilitate innovation and creativity, which are founded on knowledge-based competencies. Finally, the conceptual paper suggests that social media and, in particular, brand communities are key platforms to aid consumer decision making on luxury products, because they can engage consumers directly, and offer exclusivity by way of personalisation. Thus, the use of social media enables intimacy in the decision-making process and relationship building.
Knowledge Perspective in Indian Public Sector Undertakings
Authors: Thuse Aniruddha Vilas
Published: October 2017

In this chapter, the Public Sector Undertakings or PSUs of India are taken for discussion with specific intention. This is because of their shifting paradigm towards outsourcing, partial privatization and divestment since last few years. The Indian PSUs are going for all these strategic steps with main objective of incorporation of knowledge management into them. Knowledge Management process is the activity or initiative that any organization puts in place to enable and facilitate creation, sharing and use of knowledge for organizational benefit. The Indian PSUs are now much worried about the benefit or profitability aspect. They now will have to go strictly for Returns on Investments approach; and apart from all other investments, huge investment in knowledge sources is key requirement for them.
Crafting the Edge
Authors: Mupepi Mambo G. , Essila Jean C. , Mensah Abigail Opoku , Mupepi Sylvia C.
Published: October 2017

This chapter examines the practice of gender that underlie sexual orientation to appreciate the paradigm shift on talent and its practicality in advancing organizational effectiveness and bottom line results in successful enterprise. The discussion progresses the notion to accept the sexual identity men and women choose to progress their careers. Emotional intelligence is drawn to appreciate its impact on managerial controls and performance. Top managerial positions in enterprises have been regarded as male or female enclaves in many cultures around the globe. The trend to reflect gender as a possible social construct continues to increase in enterprises that value diversity. Change management technology is examined to how exercised by women to that of men can impact profitability and to comprehend whether there are any traits attributed to any specific gender. The perspectives are applied to model an organization acquiescent to increasing productivity in a variety of settings.