bluuebunny/crossref_metadata_2025 huggingface dataset:
Endometriosis Quality of Life Cohort Study: Long-term Impact of Radical Laparoscopic Excision of Endometriosis
Authors: McDonnell Rose , Gollow Jessica , Nathan Elizabeth , Doherty Dorota , Majumder Kingshuk , Wilkinson Eden , McElhinney Bernadette , Karthigasu Krishnan , Hart Roger
Published: February 2025

Objectives:

The objectives of this study were to determine if radical laparoscopic excision of endometriosis (RLEE) improves long-term outcomes in the quality of life (QOL) and symptomatology experienced by women with the disease. Secondary objectives include recurrence and reoperation rates and impact on fertility.

Materials and Methods:

Prospective observational cohort study Patients who underwent surgical management of histologically confirmed endometriosis completed pre- and postoperative QOL questionnaires.

Results:

Baseline preoperative scores on QOL questionnaires were lower than the population norms. Overall, 63.0% of patients improved their global health scores, and 57.5% of patients improved their health state scores from baseline to the most recent follow-up. On the Short Form-12 questionnaire, 63% of patients improved their physical and/or mental scores. Overall improvement was shown in Visual Analog Scale pain scores in menstrual pain (79.2% improved, median improvement 3, P < 0.001, n = 72), noncyclical pelvic pain (64.4% improved, median improvement 2, P < 0.001, n = 73), dyschezia (63.9% improved, median improvement 2, P < 0.001, n = 72), and dyspareunia (65.6% improved, median improvement 1, P = 0.002, n = 64 pairs). There was a significant reduction in discomfort 1–2 years after primary surgery among sexually active patients (n = 23, pre- vs. postmedian score 4 vs. 2, P = 0.005). Repeat surgery was required in 36% of patients and 77.1% of those wishing to, achieved a successful pregnancy.

Conclusion:

RLEE significantly improves global health scores, with this improvement lasting up to 10 years following index surgery. It is also suggested that this management option has the capability of improving fertility outcomes in women with endometriosis.
Successful Pregnancy after Fertility-sparing Surgery and Treatment for Metachronous Multiple Primary Malignancies — A Case Report
Authors: Mercado Mary Evangeline Villa , Huang Kuan-Gen , Lay Zin Mar , Huang Shih-Yin
Published: February 2025

The occurrence of metachronous multiple primary malignancies remains relatively rare; however, its incidence is notably rising. We present the case of a 25-year-old woman who underwent fertility-sparing surgery, followed by chemotherapy for ovarian yolk sac tumor. Three years later, the patient was diagnosed with a large B-cell lymphoma in the cecum. She underwent bowel surgery and received chemotherapy postoperatively. Despite her condition, she was able to conceive spontaneously and had a successful pregnancy after treatment. This report highlights the importance of considering fertility-preserving treatment strategies in young patients and the possibility of spontaneous conception and successful pregnancy even in patients diagnosed with metachronous multiple primary malignancies who underwent extensive surgical procedures and heavily treated with chemotherapy.
Patch Testing to Identify Allergens Causing Pigmented Contact Dermatitis: A Retrospective Study
Authors: Choubey Shini , Satish Nithya , Srinivas Chakravarthi R. , Begum Farheen
Published: February 2025

Background:

One of the prevalent dermatological conditions identified among Indian patients visiting dermatology clinics is pigmented contact dermatitis (PCD). The gold standard for diagnosing PCD is patch testing. The allergen that results in PCD and its clinico-demographic pattern could differ. Identifying the common allergens will help the clinician while treating cases with PCD.

Aim and Objective:

To determine the clinico-demographic distribution of PCD and to establish the common allergens that are responsible by patch testing.

Patients and Methods:

The study included 30 patients with PCD. All patient’s clinico-demographic profiles were recorded. The extended Indian Standard Series kit comprising of 56 antigens was used for patch testing in the outpatient department. In addition, patch testing was done with a few brands of kumkum, sacred ash, sandalwood paste, and patients own material where it was indicated. The patch test was performed and interpreted as recommended by the International Contact Dermatitis Research Group.

Results:

The male: female ratio was 1:1.7. In 21 patients (70%), face was the most common site of pigmentation. The most frequently related symptom was pruritus. Out of the 30 patients, the patch test was positive in 25 (83.3%) of the cases. Paraphenylenediamine (PPD) and fragrance mix were found to be the most common allergens in 7 (28%) and 6 (24%) patients, respectively. In 13 patients (52.2%), reaction was observed with two or more allergens.

Limitation:

The above study, followed by photo-patch testing, may have detected more allergens inducing PCD. The photo-patch test was not performed due to non-availability of allergens.

Conclusion:

PPD is the most common allergen implicated, followed by fragrances.
Pneumothorax as first presentation of ‘ABPA sans asthma’
Authors: Chopra Preeyati , Suares Rhea S. , Deshwal Rishabh , Garg Kranti
Published: February 2025

In patients with severe asthma with allergic bronchopulmonary aspergillosis (ABPA), a variety of radiological manifestations are seen. Pleural involvement is rare, and a very few case reports of secondary spontaneous pneumothorax have been reported in the literature. Here, we report an even rarer case of secondary spontaneous pneumothorax in a patient of ABPA ‘without asthma’.
Risk Factors and Prevalence of Depression in Children with Paediatric Chronic Kidney Disease: A Prospective Observational Study from India
Authors: Bhatia Navin , Pandey Shalini , Agarwal Amit
Published: February 2025

Objective:

To analyse risk factors for depression in children with paediatric chronic kidney disease (CKD) visiting haemodialysis care unit of a tertiary care hospital in Delhi, India.

Materials and Methods:

A prospective observational study, in which the study subjects were recruited from patients availing the facility of a dialysis unit at a tertiary care centre of Delhi India. The authors recruited 50 subjects who met the inclusion criteria. Child Depression Inventory (CDI) questionnaire was administered to subjects in language which they could easily understand by use of pen and paper. CDI scores, corresponding age- and sex-specific T-scores, were obtained from the table provided in CDI. The main outcome measure was to identify subjects with depression and analyse their associated risk factors.

Results:

Thirty-five out of 50 of the study participants were screened positive for depression. A positive correlation of depression was seen with female sex (P = 0.005), height <3rd centile (P = 0.014), weight <10th centile (P = 0.017), hypertension (P = 0.009), associated illnesses (P = 0.043) and students of class 6th and 9th in this study group (P = 0.046 and 0.044, respectively).

Conclusion:

Routine screening for depression should be done in all children with CKD, especially those with female sex, associated illnesses and those faltering on growth centile. CDI scoring should be done and if detected should be treated in conjunction with the psychiatrist.
Detection and Identification of Pathogenic Trypanosomes across Niger Republic–Nigeria Border by Polymerase Chain Reaction: A Case Study at Maigatari International Livestock Market, Northern Nigeria
Authors: Sabiu Nura I. , Kabir Nafisatu , Machina Idris B. , Yusuf Aminu B.
Published: February 2025

Trans-border trade among African countries has been a major route for transfer of goods and animals for centuries influencing socio-economic dynamics of regions and countries. Animal trading across borders has been implicated in the spread of several diseases and constitute a major risk to public health.The present study is aimed to investigate the role of livestock trade across Niger Republic-Nigeria border on the spread of animal African trypanosomiasis (AAT) using Maigatari International Livestock market in Northern Nigeria as a case study.To achieve this, blood samples were collected from 200 animals comprising 40 each of horses, donkeys, goats, camels and cattle brought for trading. Each sample was analysed for the presence of trypanosome spp by polymerase chain reaction using ITS1 CF and BR generic primers.The results showed an overall prevalence of 60% trypanosomes infection, with 16/40 (40%) for horse, 20/40 (50%) for donkey, 36/40 (90%) for goat, 36/40 (90%) for camel and 12/40 (30%) for cattle, respectively.The ITS1 CF and BR primers gave band sizes of 250 bp, 480 bp and above 580 bp for T. vivax, subgenus trypanozoon and T. congolense, respectively. The most prevalent trypanosome species detected were T. vivax single infection (86.7%), T. vivax/subgenus trypanozoon mixed infection (10%) and T. congolense/subgenus trypanozoon mixed infection (3.3%). These results confirmed the threat to public health pose by animal trade across Niger Republic-Nigeria border and call for strategic measures for the control and management of the spread of animal African trypanosomiasis especially as the disease is zoonotic in nature.
Dulac, Germaine (1882–1942)
Authors: Mitchell Ryan Robert
Published: February 2025

Germaine Dulac (born Charlotte Elisabeth Germaine Saisset-Schneider) directed more than thirty films bearing the traces of Impressionism, Cinéma Pur, Surrealism, and Abstraction. She is known today for her development of early feminist film theory, and her central involvement with the French avant-garde cinema movements of the 1920s. Starting her career as a feminist and radical labour journalist and activist, by 1919 Dulac had begun to explore, in Impressionism and Cinéma Pur, the aesthetic possibilities of cinema beyond the influence of either theatre or literature. Dulac sought a new cinematic language to express female desire through the cinematic depiction of an ‘other’ mode of subjectivity and expression beyond male-dominated cinema. Dulac also saw the possibility of cinema to advance feminist issues and politics, as evidenced by her Impressionist film La Souriante Madame Beudet [The Smiling Madame Beaudet] (1922/23). Focusing on the psychological and emotional toll that confinement and domesticity has on an unhappily married woman, La Souriante Madame Beudet is often cited as one of the first truly feminist films. Dulac is, however, best known for her collaboration with Antonin Artaud, who wrote the scenario for the Surrealist-inspired film La Coquille et le Clergyman [The Seashell and the Clergyman] (1928). The film’s scenario – the erotic Oedipal hallucinations of a repressed priest pursuing the wife of an authoritarian military man – certainly influenced subsequent Surrealist cinema, but Artaud and the Surrealists disowned the film due to Dulac’s aesthetic choices and the softening of Surrealism’s radical tone. By 1930, Dulac had returned to commercial filmmaking and the production of newsreels for Pathé and Gaumont.
Bourne, Randolph Silliman (1886–1918)
Authors: Tunnicliffe Kevin
Published: February 2025

Randolph Silliman Bourne (1886–1918) was born in Bloomfield, New Jersey. He was a prolific essayist for his adult life, which was tragically cut short when he contracted the Spanish Flu in 1918 at age thirty-two. His was a progressive and hopeful perspective; he celebrated diversity, believed forcefully that war only leads to destruction, and held that education could drive positive change in American society. While Bourne’s writings ranged widely, he wrote extensively on educational reform, ‘trans-national’ multiculturalism, politics and political systems – especially in the United States – anti-war and pacifist policy, the role of intellectuals in society, and disability. After earning a scholarship at the age of twenty-three, Bourne went on to graduate from Columbia University in 1912 with a Bachelor of Arts and then a Master’s degree in 1913. He then won another scholarship allowing him to spend much of the following year travelling in Europe. Bourne began writing and editing for the Columbia Monthly while a student there. During his career, Bourne wrote for some of the most influential magazines and journals, including The New Republic, The Atlantic Monthly, The Seven Arts, The Masses, The Dial, The North American Review, and The New York Times.
Eutychides’ Eurotas. A Contribution to the study of the iconography of swimmers in Ancient art
Authors: Skrzyniarz Sławomir
Published: February 2025

Pliny the Elder and Philippus of Thessalonica, when writing about a statue created by Eutychides (4th/3rd century BCE) that depicted the personification of the Eurotas River, emphasized that in this work, which has not survived to our time, the sculptural art appeared “more fluid than the river’s current” (amne liquidior) according to Pliny, and “more liquidly than water” (ὕδατος ὑγρότερος) according to Philippus. Both ancient authors likely referred to the exceptional fluidity of movement that characterized the work, accurately reflecting the identity of the depicted figure. Philippus of Thessalonica additionally noted that the artist portrayed the figure as a swimmer traversing the river’s current (ὡς […] διάβροχος ἔν τε ῥεέθροις […] ὑγροβατῶν). Since the personification of another river, the Orontes, is present in Eutychides’ most famous work – Tyche of Antioch, known from preserved sculptural copies – as a swimmer immersed in water with arms arranged in a wave-like shape (which, incidentally, creates an impression of fluidity), it can be assumed that Eutychides’ Eurotas was depicted using this very formula. The formula was innovative not only in the context of the iconography of river gods/personifications, as has been noted several times, but it also represented the earliest successful attempt to create a fully three-dimensional image of a swimming figure, which secures Eutychides’ prominent place in the history of ancient sculpture. Assuming that Eurotas, like Orontes placed at the feet of Tyche of Antioch, was depicted as a half-figure swimmer with arms arranged in a wave-like manner, it is plausible that preserved statuettes commonly interpreted as representations of Orontes inspired by the companion of Antioch’s Tyche could just as well be copies or variations of another work by Eutychides – the lost personification of Eurotas.
The assembly and annotation of two teinturier grapevine varieties, Dakapo and Rubired
Authors: Ritter Eleanore J. , Cochetel Noé , Minio Andrea , Cousins Peter , Cantu Dario , Niederhuth Chad
Published: February 2025

Teinturier grapevines, known for their pigmented flesh berries due to anthocyanin production, are valuable for enhancing the pigmentation of wine, for potential health benefits, and for investigating anthocyanin production in plants. Here, we assembled and annotated the Dakapo and Rubired genomes, two teinturier varieties. For Dakapo, we combined Nanopore sequencing, Illumina sequencing, and scaffolding to the existing grapevine assembly to generate a final assembly of 508.5 Mbp. Combining de novo annotation and lifting over annotations from the existing grapevine reference produced annotation 36,940 gene annotations for Dakapo. For Rubired, PacBio HiFi reads were assembled, scaffolded, and phased to generate a diploid assembly with two haplotypes 474.7–476.0 Mbp long. De novo annotation of the diploid Rubired genome yielded annotations for 56,681 genes. Both genomes are highly contiguous and complete. The Dakapo and Rubired genome assemblies provide genetic resources for investigations into berry flesh pigmentation and other traits of interest in grapevine.
Time and Quantile Response of Energy and Precious Metals Commodities to Cable News-Based Economic Policy Uncertainty
Authors: Ozkan Oktay , Alola Andrew Adewale , Usman Ojonugwa
Published: February 2025

Using a novel Wavelet Nonparametric Quantile Causality approach, we investigate the time-quantile predictive content of Cable News-based economic policy uncertainty (TVEPU) for energy and precious metal commodities. Our results indicate that TVEPU possesses predictive power for both energy commodities and precious metals across various periods and quantiles. Additionally, we find that the predictive power of TVEPU is stronger in higher quantiles for both causality-in-mean and causality-in-variance.
Structural Breaks and Oil-Economy Sustainability
Authors: Udeaja Elias A. , Tule Jeremiah M. , Akadiri Seyi S. , Akanni Elijah O. , Offum Peter F.
Published: February 2025

This study examines the impact of economic policy uncertainty (EPU) on environmental degradation in oil-producing African economies from 1990 to 2022, controlling for GDP and globalization. Using advanced panel tests and Granger non-causality analysis, the study finds that higher EPU reduces environmental harm, while globalization has no significant effect. It recommends economic diversification to lessen reliance on oil and mitigate environmental risks, offering key insights for policymakers.
Sustainable Markets Dynamics Under Crude Oil Volatility in the United States
Authors: Olasehinde-Williams Godwin , Akadiri Seyi S.
Published: February 2025

This study investigates the interplay between crude oil volatility and sustainable markets in the United States from January 3, 2012, to May 2, 2024, through transfer entropy and DCC-GARCH-based dynamic connectedness techniques. Overall, results show that crude oil volatility significantly influences sustainable markets. Transfer entropy results suggest that crude oil volatility is valuable for forecasting sustainable market dynamics, and DCC-GARCH analysis reveals dynamic risk spillovers, especially during key geopolitical and economic events, emphasizing the need to consider oil volatility in sustainable market decisions.
WAEMU’s Urban Jungle: Can Good Governance Tame the Green Monster?
Authors: Akpan Usenobong , Akadiri Seyi Saint , Adesanya Oladunni
Published: February 2025

Urbanization in West African Monetary Union (WAEMU) has been rapid but can lead to environmental degradation. This study investigates the relationship between urbanization and environmental degradation from 2002 to 2022. While urbanization alone is not a major culprit, it can exacerbate environmental problems when combined with other factors. Strong institutions, particularly effective governance, are crucial for mitigating these impacts. The study recommends strengthening institutions, improving regulations, and fostering regional cooperation to address WAEMU’s environmental challenges.
Do Regulated Petroleum Products Share a Long-Run Relationship With the International Market for Crude Oil? Preliminary Evidence From Fiji
Authors: Abraham Joel , Prasad Biman Chand , Narayan Paresh Kumar
Published: February 2025

In this note, we examine the long-run co-movement between the regulated domestic petroleum prices in Fiji and international market price of crude oil. The domestic petroleum prices are unique data points that are actual price control orders authorised by the price regulator. We then investigate how the crude oil market conditions affect domestic prices. Our results show that the regular price control orders on petroleum products in Fiji track the crude oil market conditions with a one-month lag. Two out of four petroleum products studied (premix and kerosene) have a stable long-run cointegrating relationship with the international crude oil market. Other products (such as, motor spirit and diesel) fail to comove with the crude oil market (or premix), suggesting that price control-order adjustments to market conditions can be further improved.
Design and Implementation of CNN-based Diabetic Retinopathy Detection
Authors: Kayes Amrul , Tanvir Aminur Rahman , Chakma Chandan , Ullah Md Redwan , Sobuj Jannatunnaim
Published: February 2025

Diabetic Retinopathy (DR), a complication of diabetes, is one of the primary causes of blindness across the globe. Detecting subtle abnormalities in retinal images, such as microaneurysms, hemorrhages, exudates, and changes in the macula, is crucial for diagnosing DR. However, manual evaluation of these images is a tedious and time-intensive process. Computer-aided systems can enhance the accuracy and efficiency of this task, enabling timely intervention to prevent or slow down vision loss. Artificial intelligence (AI), particularly in recent years, has emerged as a powerful tool for automating the detection and classification of DR in retinal fundus images.
This study explores the application of advanced deep-learning models to identify diabetic retinopathy in retinal images. Specifically, we employed Convolutional Neural Networks (CNNs), which have demonstrated exceptional performance in computer vision tasks, including medical image analysis. A publicly accessible dataset from Kaggle was utilized to train and validate the model, ensuring the reproducibility and scalability of the proposed approach.
We designed a web app to give medical practitioners support and a trustworthy second opinion on disorders that can be discovered through medical imaging. Using artificial intelligence, the platform analyzes these medical photos and classifies them into several categories. This program is intended to provide you with accurate, dependable, and quick results.
Translation Trending: Comparing Recent Trends in Indian English Fiction and English Translations of Bhasha Fiction
Authors: Thomas Sanju
Published: February 2025

For a long time now, Indian literature has meant Indian English literature to the reading public, especially in the West. This came about after Rushdie burst into the international literary scene with Midnight’s Children, a novel about India that changed the very course of Indian English fiction. Even when the translation industry in India is considered to have boomed in the 1990s, translated literature still remained largely popular only with academics and with a small discerning readership. But this seems to have changed in the new millennium. This is evident from more and more publishing houses getting involved in bringing out translations, constitution of new literary prizes solely aimed at translated literature, translated literature from India finding a place in the long lists and short lists of international awards and featuring in almost every list of Indian newspapers and magazines that bring out year-end best lists. Is translation in India getting its due share of glory now? What changed from the 1990s to the second decade of the 2000s that the tables almost seem to have turned regarding Indian English fiction and Indian fiction in English translation? The paper looks at this resurgence of translations in comparison with Indian English fiction and attempts to explore the ways these changes have come about. The paper argues that if Indian English novels have become more local, bhasha novels have become more global. The paper will focus on the recent translations from Malayalam literature to substantiate its arguments and seeks to comment on the politics of language, literature, and representation in contemporary India.
Translation of Shop Signboards: A Hermeneutic Perspective
Authors: Padhye Priyada Shridhar
Published: February 2025

The pragmatic dimension in Translation Studies broadened the area of study to include “Schildertexte” (Stolze, 1994) which were also called performative texts (Snell-Hornby, 1984) as an important text type. Though shop signboards as a text type were not explicitly mentioned, one could safely consider such texts under the rubric “Schildertexte”. In Sherry Simon’s 2019 book “Translation Sites. A Field Guide” names of hotels, bridges, markets, etc. became an area of study in translation. These are sites where translation pervades the ordinary and mundane and becomes sites of memory, migration, and translation. This article focuses on shop signboards as an area of translation study from the hermeneutic perspective. Shop signboards are usually viewed as just deictic gestures, the translation of which can be done, thanks to the realisation of Warren Weaver’s dream of FAHQT by apps like WayGo, Naver Papago Translate, and Microsoft Translator amongst many others. The minute signboards are viewed not only as deictic gestures but as hermeneutic texts, they become contested sites, sites that subvert and comply with hegemonic language policies, sites of creativity that reflect history and human migration, sites that reveal and conceal identity, in short, sites where translation is at play. This article looks at shop signboards caught in the middle of language wars, human migration, and memory from a translation perspective.
discovery of interior design education in Turkey
Authors: Faiz Büyükçam Serap , Eyüboğlu Hande
Published: February 2025

In this study, it is aimed to reveal the development of the agenda by identifying the focal scales addressed in the doctoral and proficiency in art theses produced in the discipline of interior architecture in Turkey, to draw attention to the synergies between universities and to present a chronological perspective. The study was designed with the explanatory sequential mixed method, which enables to develop an in-depth understanding of the subject and then to strengthen this understanding by making some categorisations. In the study, statistical analyses and content analyses of 227 thesis studies were carried out.  Postgraduate thesis studies produced in the field of interior architecture have increased rapidly in recent years, with design research, environmental behaviour research and building technology research being the most focused topics. Design education, theoretical concepts, space perception and user-oriented design are of great interest to students. This study is limited to the doctoral and proficiency in art thesis studies in the discipline of interior architecture that have been successfully uploaded to the Council of Higher Education (YÖK) Thesis Centre, which regulates higher education activities in Turkey. This study, which provides a detailed overview of postgraduate studies, which are a resource in professional education where social benefit is prioritised, also reveals the limited limitlessness of professional practice and education. The study presents a comprehensive map of thesis studies in the field of interior architecture and is the first comprehensive research in this field in Turkey.
ENCLOSURE AND FENCES: CONTEXTUALIZING INDIGENEITY IN JOSEPH BOYDEN’S ORENDA
Authors:   University of Belgrade, Faculty of Philology, Serbia, Glišić Dunović Marija M.
Published: February 2025

This paper delves into the profound impact of colonization on identity and place, themes that are critically examined in Joseph Boyden’s novel, The Orenda. The unique indigeneity phenomenon and the indigenous realm’s restrictions are explored in intimate narratives, inviting us to deeply reflect on the human discontinuity between past and present, displacement from the natural habitat, and fragmentation of tormented souls. The story also presents the marginality of oppressed groups and liminality marked by uncertainty that are a direct result of colonization’s influence, painting a vivid picture of the harsh realities faced by Indigenous Peoples. Boyden’s chronicle is a testament to the resilience and determination of Indigenous Peoples, who steadfastly held onto their cultural values despite the Christianization and imposed conflicts. Defence of land sovereignty is a quest for personal and national identity. Indigenous voices in this novel not only echo the past but also demonstrate the survival of Indigenous Peoples as stewards of the Earth. There is a dynamic at play. Under some circumstances, the other, a term referring to those who are different or outside the dominant group, takes the position of the self, as in Boyden’s identity crisis. We approach the analysis of power vastness from Derrida’s deconstructionist point of view, questioning the destructive effects of binary oppositions.
IZMEĐU ŽELJE I PORETKA: PSIHOLOŠKI PORTRET INTELEKTUALCA U PRIPOVETKAMA LAZE LAZAREVIĆA
Authors:   University of Belgrade, Faculty of Philology, Serbia, Petrov Bojana Č.
Published: February 2025

The literary character of the intellectual is one of the most impressive
structural elements of Laza Lazarević’s short stories. In accordance with the poetic
commandments of realism to objectively depict social reality, the circumstances
of the time were the inspiration for the genesis of many themes and characters in
Serbian literature. Generations of intellectuals who were growing up at that time were transposed into the literary world, so the genesis of the character of an intel-
lectual can be partly explained by prototypicality. The main characters of the stories
Werther, Vetar, and Švabica will be interpreted in the paper as typical, because they
have referents in reality, but also as typified, because there are several of them with
similar psychological characteristics. Apart from the structuralist and narratological
point of view, the literary type of the intellectual will also be considered through a
psychological approach, based on Goleman’s study Emotional Intelligence and Leo
Bersani’s text on the fear of desire in realism. Finally, Janko-Werther, Janko from
Vetar, and Miša Maričić will also be interpreted from the aspect of the genesis of
intellectual hero in a wider literary-historical arc – between the French arrivistes
and the intellectuals of Bora Stanković.
Block chain technology in healthcare: challenges and opportunities
Authors: K Naga Rani , K Pravallika , Sk Nadiya , T Poojitha , K Greeshma
Published: February 2025

Patients and healthcare practitioners are faced with the challenge of accessing, managing, integrating, and sharing health records securely. Patients should be able to manage their health records anywhere in the world, keep track of medical background, give access to data, and share those with any healthcare professional securely. Direct access to data for patients and a more robust data-sharing infrastructure could better prepare the healthcare system to manage public health threats during the emergence of deadly disease outbreak such as COVID-19. Current technologies in use by the healthcare industry do not adequately address these requirements due to limitations related to privacy, security, and full ecosystem interoperability. This paper conducted a literature review to find out the pivotal roles blockchain technology play in solving some of the most critical and challenging issues facing the healthcare industry. This paper identifies challenges and opportunities for implementing blockchain technology in healthcare and summarizes health-related blockchain products and key players offering solutions across different applications. In doing this, our research extends and complements existing blockchain research in healthcare.
Plants used for antimicrobial activity: a review
Authors: AK Anusmaya , MK Dhwani , Swetha Kt  , D Roopa , Dr Bharathi , M Rupesh Kumar , Syed Sagheer Ahmed
Published: February 2025

The rising prevalence of antibiotic-resistant bacteria has long been a source of concern in the scientific community. Many experts across the world are doing plant study in order to uncover potential antibacterial chemicals. Many plants secondary compounds have been shown to exhibit a wide range of biological functions. Antibacterial, antifungal, and anticancer properties may be present. The present review shows the plants recently used for antimicrobial activity.
Clinical trials on oncology studies- a review
Authors: D Blessy Jyothsna Saroja , Harikeerthi Sampreethi , V C.Randeep Raj
Published: February 2025

Clinical trials plays major role in making the drug safety and effective for the patients suffering from diseases. Cancer disease is one of the leading causes of deaths. Oncology clinical trials are very crucial for the patients, as this might be the only hope for the survival. However, eligibility criteria decides the patients participating in the trial and all the patients should be screened molecularly. There are certain barriers that shut out the patients from enrolling in the clinical trials. Age, gender, race, family status, literacy also affects the patient’s participation into the trials. Of all the population participating in clinical trials, elderly population represents almost 25-30%. There are different phases in the clinical trials like Phase 1, Phase 2, Phase 3 and Phase 4 with different criteria and different endpoints. Phase 1 aims on safety, phase 2 aims on efficacy, phase 3 aims on the therapeutic effect of drug, whereas phase 4 deals with the long-term effects of the drug in the market.
Risk based monitoring in clinical trial-a review
Authors: Rastogi Vishal , Vijayagiri Umasri , Manasa Aparna , V C.Randeep raj
Published: February 2025

Risk based  monitoring  is  the  targeted approach in clinical trials for maintaining proper data integrity, protection of safety, rights of subjects and good of the trial subjects. The system of onsite monitoring by CRA was time uncontrollable and very effective. But now a day’s technology advancements and pandemic are encouraged to remotely collecting and imaging large data including data tracking site performance. Also enabling identification of trends, risk before selling the drug. The US FDA, proposed these approach of risk based monitoring (RBM). The drive to RBM at assiduity position started in August 2013. These review composition grounded on approach to RBM substantially concentrate on safety of subjects, quality of data and also for quickly and effectively mitigati.ng pitfalls before they compromise trial quality. These paper also provides the information regarding impact of covid19 in clinical trial monitoring and displacements of trial conditioning during the pandemic period. The pandemic situations forced companies to calculate substantially on remote and centralized monitoring due to point closures. The RBM geography check showed remote site monitoring increased and on site monitoring dropped at the peak of the pandemic in April compared with the pre-pandemic. These check also showed that chance of remote point observing visits increased from 18 in February to a high of 93 in April. The check concluded that RBM relinquishment before the COVID- 19 pandemic wasn't as wide as anticipated.
Review on role of nrf2 pathway activation in neurological disorder
Authors: K Manisha , K Loganadhan , M Aswini , M Rajesh Kumar , R Gautham Chakra , K Swathi Krishna
Published: February 2025

With protein build-up and mitochondrial damage leading to brain problems, oxidative stress is a key factor in the onset of many neurodegenerative illnesses. Several defence systems, including nuclear erythroid factor2 (Nrf2)-Kelch-like ECH-associated protein1, protect nerve cells by producing antioxidants to reduce oxidative stress (Keap1) In a number of neurological illnesses, signalling pathway activation has been shown to be a promising therapeutic for reducing oxidative stress and neuroinflammation and protecting neurons. In this review, we specifically highlight Nrf2's beneficial effects on Alzheimer's and Parkinson's disorders. By releasing over 250 cytoprotective genes intended to combat oxidative stress and neuroinflammation, Nrf2 has demonstrated that it is a master regulator of antioxidants. It has been demonstrated in animal experiments that Nrf2 activation enhances autophagy, mitochondrial biogenesis, and the suppression of inflammatory cytokinin which protects neuronal cells and inhibit progressive neurodegeneration.
Effect of statins in cardiovascular diseases: a prospective observational study
Authors: D Niveditha , T Venkata Srikanth , Begum Karimunnisa , K Swathi Priya
Published: February 2025

Cardiovascular diseases also called heart diseases which include a group of disorders of the heart and blood vessels. Cardiovascular diseases (CVDs) are the leading cause of death globally. The study was aimed to explore the effect of statins in cardiovascular diseases- chronic stable angina, acute coronary syndrome and in post PTCA patients by monitoring the lipid profile. The study was conducted in the Cardiology department in the Queen’s NRI Hospital. This is a prospective, non-interventional and observational study and 100 population attending Cardiology OPD & IPD in Queen’s NRI Hospital were recruited into the study with their informed consent. This research reported that the cardiovascular diseases in male with prevalence (63%) out of 100 patients and female with prevalence (37%) out of 100 and the prevalence of CSA is 15%, post PTCA is 21%, and ACS is 64% from a total estimation of the study. By using Paired T test the mean difference, estimated variance, standard error of difference, test statistic, test critical are calculated and the comparison between test statistic and critical value. The test statistic is greater than critical t value the alternate hypothesis is accepted by taking the level of significance α = 0.05 and p value less than 0.05 and there is a significant change in lipid profile parameters by using the statins and hence the study is statistically significant with positive outcome.
Nanoparticles Using Speedometer
Authors: Maganti Manohar
Published: February 2025

It involves using extremely tiny material particles to produce new, large-scale materials. Nanoparticles are described as submicrometer (10–1000 nm) colloidal systems composed primarily of polymers, whether or not they are biodegradable. Birrenbach and Speiser (1976) developed them initially.Chemical or mechanical sensors that can be used to track physical characteristics like temperature on the nanoscale, as well as identify the presence of chemical species and nanoparticles, are known as nanosensors. When a material is in nanoparticle form, its high surface area facilitates the large-scale diffusion of heat, chemicals, and ions into and out of the particles. Conversely, the material can quickly approach homogenous equilibrium with respect to diffusion because of the tiny particle diameter. Materials that range in size from 1 to 100 nm are known as nanoparticles. They can be divided into many classes according on their characteristics, sizes, or forms. Materials in the 1-100 nm size range are called nanoparticles. The unit used to measure nanometers is nm, and they are one billionth the size of a meter.
Nano sponges Drug Delivery System Role in Cancer Therapy
Authors: Pilli Sushma
Published: February 2025

A kind of nanoparticles known as "nano sponges" is distinguished by high loading capacity due to its surface resembling a sponge. Cancer has a high death rate and necessitates careful management that doesn't damage the body. Because of this, drugs must be targeted to tumors using nanoparticles. The creation of new colloidal, porous, microscopic mesh-like carriers called Nano sponges, which have a size range of 1 μm and provide regulated medication delivery to a particular spot in the treatment of cancer. Drug delivery can be targeted in a regulated way with the help of nano sponges. Drugs of all kinds, both hydrophilic and lipophilic, can be placed onto nano sponges to target drug delivery and ultimately increase the solubility and bioavailability of the same medication. The body as a whole can be filled with nano sponge.
A brief article on Cosmetovigilence the ongoing and systematic monitoring of safety and adverse effects of cosmetics
Authors: Ramisetty Sailaja
Published: February 2025

Cosmetovigilence is the study of cosmetic products from a public health perspective. The Saudi Food and Drug Authority has assumed responsibility for regulating cosmetic items and issuing recommendations to ensure their safety due to the drastic growth of beauty products in Saudi Arabia. Addressing the safety of cosmetic goods is widely recognized as a public health concept. In tertiary care hospitals, identify potentially dangerous impacts from cosmetic goods and take appropriate action to prevent them. The goals of this text are to cater to the demands of dermatologists, scientists, cosmetic chemists, and formulators who have to grasp a variety of topics in order to develop innovative, successful skin care products for a particular market. In addition to chemicals, physical and biological risk factors also manifest in the skin, which is the biggest organ in the body.
Role of Novel Natural Resources in the Treatment of Psoriasis
Authors: Ravuri Thanuja
Published: February 2025

There is no long-term treatment for psoriasis, an inflammatory immune-mediated illness. Elbows, lower back, scalp, knees, and other body parts may become inflamed as a result of this illness. Biologics are now being used to treat psoriasis; however, because of their highly targeted inflammatory mediators, the immune system may be able to go around the blockade and cause a relapse of the illness as well as other clinical and immunological symptoms. Because of their structural diversity and multiple active individuals across ages mechanisms, natural compounds isolated from herbal medications have synergistic actions to treat psoriasis and its comorbidities. Together with certain immunological molecules including TNF, IL-12, IL-23, IL-17, and other molecules that can contribute to the pathogenesis of psoriasis, the properties of natural products have T cells that clearly play a part in the disease's pathogenesis. Because they are readily available and safe, herbal medications may have anti-psoriatic properties. To create a powerful, secure, and dependable treatment, more scientific research on these herbal resources is required.
An Overview of Novel Drug Therapies for Viral Myocarditis
Authors: Shaik Ghan Saida
Published: February 2025

Sudden cardiac death usually follows a cardiotropic viral infection, which is followed by aggressive inflammatory destruction of the myocardium. Myocarditis is a common cause of dilated cardiomyopathy. This disease's variable clinical manifestations and range of aetiologies have made it difficult to characterize. Viral infections are the primary cause of inflammatory cardiomyopathy. Developments in cardiac MRI and molecular viral identification using endomyocardial biopsies have enhanced our capacity to identify and comprehend the pathophysiological underpinnings of this enigmatic illness. For both the acute and chronic stages of myocarditis, there are currently few treatment options available. Immunosuppressive and immunomodulatory treatments have shown promise in a number of randomized, controlled trials; nonetheless, more research is necessary. This Review delves into the pathogenesis, natural history, diagnosis methods, and evidence-based therapy approaches for myocarditis. The field of myocarditis treatments is set to advance with the development of new imaging modalities and human in vitro disease models.
A Brief Review of its Pharmacological Properties of Acalypha Indica
Authors: Shaik Rasoolbee
Published: February 2025

With more individuals looking for health solutions and treatments free from artificial chemical side effects, medicinal plants are making the transition from being used only in border areas to mainstream settings. More than 3500 plants have official medical recognition in India. In India, around 6000 plants are reportedly used in folk, traditional, and herbal medicine. The traditional medicine system of India and many other nations uses this plant, which is said to have anti-inflammatory, anti-tumor, anti-diabetic, antioxidant, anti-bacterial, antifungal, hepatoprotective, and anti-cancer properties. It is also used to monitor wound and ulcer healing. Glycosides, flavonoids, and tannins are all recognized to be abundant in it. Acalypha indicica's therapeutic benefits, medicinal qualities, and studies on its secondary metabolites demonstrate its significance as a useful medication.
Current Developments of Nanotechnology in Mending Chronic Wounds
Authors: Singamareddy Sai Deepthi
Published: February 2025

A number of reasons inhibit the healing process in the wound healing phase, which is a natural and well-designed process. Millions of individuals worldwide are impacted by poor wound healing, which raises the associated mortality rates. Modern medicine and nanotechnology work together to generate new materials and gadgets at the nanoscale, which could revolutionize the way that macroscale treatments are now provided. Through antibacterial, anti-inflammatory, and angiogenic activities that transition the wound milieu from nonhealing to healing, nanomaterials can activate a variety of cellular and molecular pathways that support wound healing. The tiny nanomaterials, nanoscaffolds, nanofibers, and biomaterials utilized in nanotechnology for topical medication administration to promote wound healing. Prior research has shown that nanotechnology has numerous benefits for medical treatment. This review aims to demonstrate how biodegradable and nanoparticle-based materials can aid in the healing of wounds. the future paths of existing technology while going over possible approaches that can help the area of wound healing progress. This article focuses on the pathophysiology and mechanics of wound healing.
Revolution of 3d printing in pharmaceuticals: innovations, applications, and future perspectives
Authors: Soni Sanket J
Published: February 2025

3D printing, or additive manufacturing, is transforming the pharmaceutical industry by enabling the precise fabrication of complex drug formulations, personalized dosages, and advanced drug delivery systems. Initially utilized in aerospace and automotive industries, 3D printing has rapidly been adopted in pharmaceuticals, offering new opportunities for customized medicine, rapid prototyping, and on-demand drug manufacturing. This review explores the current advancements in 3D printing technologies, such as Fused Deposition Modeling (FDM), Stereolithography (SLA), Selective Laser Sintering (SLS), Inkjet Printing, and Extrusion-Based Printing. These technologies have shown significant potential in creating personalized medication, developing complex drug delivery systems, and addressing pediatric and geriatric populations' unique needs. Despite these advancements, challenges still need to be addressed, including regulatory hurdles, technical limitations, scalability issues, and intellectual property concerns. Future directions include integrating 3D printing with digital health technologies for real-time patient monitoring and personalized treatment, developing advanced materials and printing technologies, and evolving regulatory frameworks to accommodate the growing use of 3D printing in pharmaceuticals. Collaborative research and development are crucial to overcoming these challenges and realizing the full potential of 3D printing in revolutionizing drug manufacturing and delivery, particularly in improving global accessibility to essential medicines.
A systematic review on chronic respiratory infection in patients with chronic obstructive pulmonary disease
Authors: K Saranya , Jk Vandana Singh , K Vijaya Sree , P Narayana Swamy , Y Ramesh , Y Prapurna Chandra
Published: February 2025

Chronic infections are associated with exacerbation in patients with chronic obstructive pulmonary disease (COPD). The major objective of the management of these patients is the prevention and effective treatment of exacerbations. Patients that have increased sputum production, associated with purulence and worsening shortness of breath, are the ones that will benefit from antibiotic therapy. It is important to give the appropriate antibiotic therapy to prevent treatment failure, relapse, and the emergence of resistant pathogens. In some patients, systemic corticosteroids are also indicated to improve symptoms. In order to identify which patients are more likely to benefit from these therapies, clinical guidelines recommend stratifying patients based on their risk factor associated with poor outcome or recurrence. It has been identified that patients with more severe disease, recurrent infection and presence of purulent sputum are the ones that will be more likely to benefit from this therapy. There is a need to design long-term studies to evaluate these interventions in the natural history of the disease. The purpose of this publication is to review our understanding of the role of bacterial infection in patients with COPD exacerbation, the role of antibiotics, and future interventions.
Keywords: c; exacerbations of chronic obstructive pulmonary disease; antibiotics; bacteria; prevention; colonization.