bluuebunny/crossref_metadata_2025 huggingface dataset:
Demystifying China’s Involvement in African Peace and Security Architecture
Authors: Sibiri Hagan
Published: June 2021

Until the last decade, Peace and Security (PAS) issues were among the least discussed topic in the budding China–Africa relations. However, China’s recent involvement in African Peace and Security Architecture (APSA) has attracted critical review. Critics aver that China’s expanding security engagement in Africa is a clear manifestation of China’s willingness to use its growing military to challenge the global status quo. This paper reviews China’s involvement in APSA to ascertain whether the realities of China’s PAS engagement in Africa support the ‘China Threat’ narrative (zhōngguó wēixié lùn). The paper establishes that, albeit the considerable flexibility in China’s foreign security policies, many of its aspects are still guided by the policy constraints of sovereignty, non-interference, and non-aggression. By upholding these policy constraints, China’s involvement in APSA has occurred on a constructive interactive basis and principally within the multilateral frameworks and mandate of regional and international bodies. However, the novelty is that China has taken an endogenous viewpoint in its security engagement with Africa that is hinged on the idea that Africa’s problems must be confronted with African solutions and capabilities. This is manifested in the increasing level of functional security exchanges and capacity-building activities to enhance African countries’ security capabilities to confront common security challenges independently.
The Scourge of Online Solutions and an Academic Hertzsprung–Russell Diagram
Authors: Overduin James , Buchman Jacob , Perry Jonathan , Krause Thomas
Published: June 2021

We report on preliminary results of a statistical study of student performance in more than a decade of calculus-based introductory physics courses. Treating average homework and test grades as proxies for student effort and comprehension, respectively, we plot comprehension versus effort in an academic version of the astronomical Hertzsprung–Russell diagram (which plots stellar luminosity versus temperature). We study the evolution of this diagram with time, finding that the “academic main sequence” has begun to break down in recent years as student achievement on tests has become decoupled from homework grades. We present evidence that this breakdown is likely related to the emergence of easily accessible online solutions to most textbook problems, and discuss possible responses and strategies for maintaining and enhancing student learning in the online era.
Designing of Inorganic Al12N12 Nanocluster with Fe, Co, Ni, Cu and Zn Metals for Efficient Hydrogen Storage Materials
Authors: Mehboob Muhammad Yasir , Hussain Fakhar , Hussain Riaz , Ali Shaukat , Irshad Zobia , Adnan Muhammad , Ayub Khurshid
Published: June 2021

Hydrogen is considered as one of the attractive environmentally friendly materials with zero carbon emission. Hydrogen storage is still challenging for its use in various energy applications. That’s why hydrogen gained more and more attention to become a major fuel of today’s energy consumption. Therefore, nowadays, hydrogen storage materials are under extensive research. Herein, efforts are being devoted to design efficient systems which could be used for future hydrogen storage purposes. To this end, we have employed density functional theory (DFT) to optimize the geometries of the designed inorganic Al[Formula: see text]N[Formula: see text] nanoclusters with transition metals (Fe, Co, Ni, Cu and Zn). Various positions of metal encapsulated Al[Formula: see text]N[Formula: see text] are examined for efficient hydrogen adsorption. After adsorption of H2 on late transition metals encapsulated Al[Formula: see text]N[Formula: see text] nanocluster, different geometric parameters like frontier molecular orbitals, adsorption energies and nature bonding orbitals have been performed for exploring the potential of metal encapsulated for hydrogen adsorption. Moreover, molecular electrostatic potential (MEP) analysis was also performed in order to explore the different charge separation upon H2 adsorption on metals encapsulated Al[Formula: see text]N[Formula: see text] nanoclusters. Also, global indices of reactivity like ionization potential, electron affinity, electrophilic index, chemical softness and chemical hardness were also examined by using DFT. The adsorption energy results suggested encapsulation of late transition metals in Al[Formula: see text]N[Formula: see text] nanocage efficiently enhancing the adsorption capability of Al[Formula: see text]N[Formula: see text] for hydrogen adsorption. Results of all analysis suggested that our designed systems are efficient candidates for hydrogen adsorption. Thus, we recommended a novel kind of systems for hydrogen storage materials.
Molecular Docking Study of Antibiotics, Anti-Inflammatory Drugs and [Eu(TTA)3⋅AMX] Complex as COVID-19 Biomarker through Interaction of Its Main Protease (Mpro)
Authors: da Fonseca Aluísio Marques , de Araújo Francisco Aurecio Morais , Carvalho Rubson Mateus Matos , Silva de Menezes Jorge Fernando , Sá Pires Silva Andrei Marcelino
Published: June 2021

Coronavirus Acute Respiratory Syndrome (SARS-CoV-2) is a very recent viral infection and has generated one of the world’s biggest problems of all time. There is no scientific evidence and clinical trials to indicate that possible therapies have shown results in suspected or confirmed patients other than the use of immunizations. Given the above, some substances are being studied to be applied to contain their spread and further damage. This work aims to perform an in silico study of amoxicillin, widely known as an antibiotic and used to prevent bacterial infections and a possible biomarker made from a complex with Europium (Eu). It was shown to have the ability to interact with the COVID-19 protein in Mproprotease as ligands. The study was conducted using the AutoDock Vina with Lamarckian genetic model algorithm (GA) combined with the estimation of grid-based energy in rigid and flexible conformation. Compared to affinity energy, amoxicillin presented [Formula: see text][Formula: see text]kcal/mol, which was better than its co-crystallized ligand in the study. The Europium complex, where its synthesis was also demonstrated in this work, presented energy of [Formula: see text][Formula: see text]kcal/mol with hydrogen bonds and possible color change when UV light was applied. For the choice of the best poses in the simulation, the neural network parameter, NNScore2, was used. It can be affirmed that this study is still introductory but promising both in the treatment and identification of the virus.
Some Fixed Point Results of Kannan Maps on the Nakano Sequence Space
Authors: Bakery Awad A. , Mohamed O. M. Kalthum S. K.
Published: June 2021

In the recent past, some researchers studied some fixed point results on the modular variable exponent sequence spaceℓr.ψ, whereψv=∑a=0∞1/ravaraandra≥1. They depended on their proof that the modularψhas the Fatou property. But we have explained that this result is incorrect. Hence, in this paper, the concept of the premodular, which generalizes the modular, on the Nakano sequence space such as its variable exponent in1,∞and the operator ideal constructed by this sequence space ands-numbers is introduced. We construct the existence of a fixed point of Kannan contraction mapping and Kannan nonexpansive mapping acting on this space. It is interesting that several numerical experiments are presented to illustrate our results. Additionally, some successful applications to the existence of solutions of summable equations are introduced. The novelty lies in the fact that our main results have improved some well-known theorems before, which concerned the variable exponent in the aforementioned space.
Synchronization Problem of a Novel Fractal-Fractional Orders’ Hyperchaotic Finance System
Authors: Zhang Yaru , Du Yingxue
Published: June 2021

This paper investigates the synchronization problem of a novel fractal-fractional (FF) orders’ hyperchaotic finance system with model uncertainty and external disturbance. Firstly, a controller is designed to realize the synchronization of the nominal FF-orders’ hyperchaotic finance system. Secondly, a suitable filer is designed to estimate uncertainty and disturbance, and then, the uncertainty and disturbance estimator- (UDE-) based control method is proposed to realize the synchronization problem of such system. Finally, numerical simulations are carried out to verify the correctness and the effectiveness of the obtained results.
Observational Study of Qigong as a Complementary Self-Care Practice at a Tertiary-Care Pain Management Unit
Authors: Curry Lauren , Pike Meghan , Lynch Mary , Marcon Dana , Sawynok Jana
Published: June 2021

Qigong, which can be characterized in many different ways, is offered as a complementary self-care practice at a tertiary-care pain management unit in Halifax, Nova Scotia. This report provides a quantitative and qualitative assessment of two groups engaged in qigong practice in this context as part of two Research in Medicine (RIM) projects (2014-15, 2016-17). It includes assessments of pain, mood, quality of life, sleep, and fatigue, considers outcomes in relation to the amount of practice, and considers whether health attitudes would help determine who might benefit from the practice. There were 43 participants (28 ongoing practitioners, 15 new to qigong). The ongoing practice group in RIM2 had significant benefits over time in pain, mood, quality of life, and fatigue in quantitative scores, but changes were not significant in RIM 1. There were no differences in any measures in those new to qigong. Qualitative comments in core and other domains reflected good or better outcomes in 16 subjects in the ongoing group who practiced consistently. In those who practiced less, results were more variable. In most of those new to qigong, the practice was limited and comments indicate minimal changes. Those engaged in qigong have a stronger internal health locus of control than control subjects. Diligent qigong practice provides multiple health benefits for those with chronic pain, and qualitative assessments are essential for documenting these effects. For those new to qigong, factors needed to effectively engage practice need to be explored further to optimize program delivery. The trial is registered with http://www.clinicaltrials.gov (NCT04279639).
Stability Analysis of Underground Pillar Supporting System under Different Disturbed Stresses
Authors: Li Yang , Liu Limin , Zhang Jinpeng , Liu Chuanxiao , Zhang Mengyao , Wang Xiujuan
Published: June 2021

Small external disturbances may destabilize the bearing pillar, which in turn will change the stress distribution of the pillar supporting system, leading to its overall instability. Based on the engineering background of a mine and the mechanical analysis of pillar under disturbed stress, this paper investigated the stress, strain, and plastic zone of the pillar supporting system under different disturbed stresses. Then, the chain instability of the pillar supporting system was achieved. The law of stress transfer and plastic development of the pillar supporting system was explored. The results showed that the greater the disturbed stress, the faster the increase rate of the maximum stress of the pillar supporting system. As the width of the pillar increased, the maximum stress of the pillar decreased, so its risk of damage decreased. As the disturbed stress increased, the maximum principal strain and equivalent plastic strain of the 6 m wide pillar increased approximately linearly, and their growth rates of the 4 m wide pillar gradually increased. In the process of chain instability of the pillar supporting system, the sides of the middle pillar were destroyed first, and then the plastic zone gradually penetrated, causing the stress of the adjacent pillar to increase, which in turn led to its destruction. By analyzing the monitoring data of stress, displacement, or plastic strain, the instability of the pillar can be predicted.
Sources of Nitrate in Ground Water Aquifers of the Semiarid Region of Tanzania
Authors: Alex Rita , Kitalika Aldo , Mogusu Emmanuel , Njau Karoli
Published: June 2021

Nitrate isotopic values are often used as a tool to identify sources of nitrate in order to effectively manage ground water quality. In this study, the concentrations of NO3−, NO2−, and NH4+ from 50 boreholes and shallow wells in the Singida and Manyoni Districts were analyzed during the dry and wet seasons, followed by identification of nitrate sources using the hydrochemical method (NO3−/Cl−) and stable isotope (δ15N and δ18O) techniques. Results showed that NO2− and NH4+ concentrations were very low in both seasons due to the nitrification process. The concentrations of NO3− ranged from 2.4 ppm to 929.6 ppm with mean values of

118.5
 
ppm
±
118.5
 
ppm

, during the dry season and from 2.4 ppm to 1620.0 ppm with mean values of

171.6
 
ppm
±
312.3
 
ppm

, during the wet season. The higher NO3− contamination observed in the wet season could be due to rainfall which accelerated the surface runoff that collects different materials from various settings into the ground water sources. Nitrate source identification through hydrochemical technique revealed that most nitrates originated from sewage effluents and/or organic wastes such as manure. Likewise, the mean values of δ15N-NO3− (

+
20.90
‰
±
5.17
‰

and

+
18.30
‰
±
6.33
‰

) and the mean values of δ18O-NO3−(

+
13.86
‰
±
3.18
‰

and

+
13.69
‰
±
3.97
‰

) suggest that 80% of boreholes and 52% of shallow wells were dominated with nitrate from sewage effluents and/or manure as most ground water sources were situated in densely populated areas with congested and poorly constructed onsite sanitation facilities such as pit latrines and manure. Therefore, to reduce nitrate pollution in the study area, a central sewer must be constructed to treat the discharged wastes. Also, groundwater harvesting should consider the proper principles for groundwater harvesting recommended by the respective authority to minimize chances of contamination and hence prevention of health risk.
Expansion Velocity Model of Steam-Assisted Gravity Drainage considering Thermal Convection
Authors: Du Dian-Fa , Zhang Yao-Zu , Zhang Li-Na , Xu Meng-Ran , Liu Xin
Published: June 2021

Steam-assisted gravity drainage (SAGD) is an important method used in the development of heavy oil. A heat transfer model in the SAGD production process is established based on the heat transfer effect caused by the temperature difference at the front edge of the steam chamber and the heat convection effect caused by the pressure difference. The observation well temperature method is used in this model to calculate the horizontal expansion speed of the steam chamber. In this manner, an expansion speed model considering heat convection and heat conduction is established for a steam chamber with a steam-assisted gravity drainage system. By comparing this with the production data extracted from the Fengcheng Oilfield target block, it is verified that the model can be effectively applied for actual field development. Simultaneously, by using the derived model, the temperature distribution at the edge of the steam chamber and production forecast can be predicted. Sensitivity analysis of the expansion rate of the steam chamber demonstrates that the larger the thermal conductivity, the faster is the steam chamber horizontal expansion speed, and the two are positively correlated; the larger the reservoir heat capacity, the slower is the steam chamber horizontal expansion speed. A larger heat capacity of the convective liquid indicates that there are more water components in the convective liquid, the viscosity of the convective liquid is low, and the expansion speed of the steam chamber increases accordingly. This research closely integrates theory with actual field production and provides theoretical support for the development of heavy oil reservoirs.
Body Balance and Physiotherapy in the Aquatic Environment and at a Gym
Authors: Pieniążek Magdalena , Mańko Grzegorz , Spieszny Michał , Bilski Jan , Kurzydło Wojciech , Ambroży Tadeusz , Jaszczur-Nowicki Jarosław
Published: June 2021

The increase in the average age of our society represents a growing medical and social problem, which requires concentration on the issue concerning balance disorders. The aquatic environment has a number of complex properties that have miscellaneous effects on the human body. In the light of the above, water is becoming an ideal environment to learn correct neuromuscular communication, and a properly prepared training session in water helps to practice balance and movement coordination. The objective of the study was to assess the impact of rehabilitation in the aquatic environment on patients’ balance and compare the results obtained with patients who received rehabilitation at a gym. The study was carried out among patients hospitalised in the “Krzeszowice” Rehabilitation Centre. It encompassed 137 patients, randomly assigned to either the study group (the aquatic environment) or the control group (the gym). The preliminary examination included general medical history and a test on the stabilometric platform. The patients attended training sessions for 4 weeks, 5 times a week for 30 minutes. It was a single‐blinded study wherein the authors did not know which group a given patient had been assigned to. Upon completion of a monthly therapy, the stabilometric test was carried out again. The study revealed that the patients from both groups experienced a significant improvement in balance. However, the improvement was slightly greater in those exercising in the pool. Physiotherapy in the aquatic environment makes a greater contribution to the improvement of body balance compared to physical exercises performed at a gym.
Influence of Particle Size Distribution on the Physical Characteristics of Pore-Filling Hydrate-Bearing Sediment
Authors: Wu Peng , Yang Shenghua , Wang Le , Song Xiangge , Li Yanghui
Published: June 2021

Nature gas hydrates (NGHs) are regarded as a potential alternative energy source due to their huge reserves and wide distribution. According to the geophysical surveys, the pore-filling hydrates occupy a large proportion of the global hydrate reserves, especially for the marine regions. Therefore, with a novel pore-scale 3D morphological modeling algorithm, this study systematically studied the effect of the particle size on the physical characteristics of the pore-filling hydrate-bearing sediment (HBS). The pore system evaluations and permeability simulations were performed by utilizing pore network modeling (PNM), and the thermal and electrical simulations were conducted by utilizing a finite volume method (FVM). The results show that for the HBS with smaller particle size, the average radius of the pores and throats would also be reduced, and the fractal dimension of the pore system would be increased. In addition, with the increasing hydrate saturation, the fractal dimension of the pore system will increase firstly and then decrease. And these parameter evolutions could impact the physical properties correspondingly; specifically, the decreasing particle size in the HBS would reduce the permeability and electrical conductivity of HBS and enhance the apparent thermal conductivity of HBS.
Condición juvenil en tiempos de guerra: relatos desde la ruralidad colombiana
Authors: Rovira Rubio Rayen Amanda , León Saavedra Patricia Elizabeth
Published: June 2021

(analítico)El artículo analiza las implicaciones de la guerra en la configuración del ser joven rural en Colombia en La Merced (Caldas) y Vista Hermosa (Meta). Es una investigación cualitativa con enfoque narrativo, que indaga en las experiencias de tres sobrevivientes de la violencia entre los años 1995 y 2005, por medio de marcadores de juventud. De los resultados se desprende que la guerra trazó cursos de vida a los jóvenes rurales, como ser cultivadores de hoja de coca e integrantes de grupos armados, marcándose transiciones en las que se restringieron las capacidades para agenciar posibilidades de futuro fuera de los marcos de la guerra, pero también cursos de vida en resistencia vinculados a la acción colectiva con otros jóvenes.
Palabras clave: Joven rural, guerra, violencia, memoria colectiva, (Tesauro de Ciencias Sociales de la Unesco).
Ambiências urbanas no behaviorismo espacial e na fenomenologia da percepção
Authors: Silva Leonardo Oliveira Muniz da , Duarte Cristiane Rose de Siqueira
Published: June 2021

Na pesquisa em Arquitetura, as ambiências urbanas são analisadas a partir de categorias espaciais ou da experiência do corpo no mundo. Ambas as perspectivas se conformam na realidade, sugerindo uma superação do dualismo clássico e uma compreensão total das ambiências. Assim, este artigo objetivou estruturar, conceitualmente, as ambiências urbanas por meio de perspectivas metodológicas adversas em um sentido interdisciplinar. A interlocução dos autores demonstrou a necessidade de uma fundação fenomenológica dos espaços, no entanto, abordando estes, primeiramente, por meio de deferências fornecidas pelo intelectualismo, para a elaboração de hipóteses. Assim, permitiu-se construir uma compreensão das ambiências percebidas e realizadas pelo sujeito e por si mesma, uma unidade espacial própria dotada de valores advindos da mutualidade sujeito-mundo.
Lei nº 13.465: a Regularização Fundiária no Brasil e suas novas injunções
Authors: Gonçalves Ana Luiza Vieira , Rizek Cibele Saliba
Published: June 2021

Esse artigo se dedica a explorar as injunções que se desenham com a nova lei de regularização fundiária (13.465/2017), a partir de uma concepção do contexto de  elaboração e aprovação da lei e da perspectiva de redução do caráter anterior de resistência que marcava os processos de regularização fundiária de interesse social e da ruptura que se coloca com relação à política vigente em âmbito nacional de formação e capacitação dos gestores públicos para atuação em processos de regularização fundiária. O trabalho se realiza a partir de uma Iniciação Científica financiada pelo CNPq, entre agosto de 2018 e julho de 2019.
Temporal Trends and Drivers of Heart Team Utilization in Transcatheter Aortic Valve Replacement: A Population‐Based Study in Ontario, Canada
Authors: Marcus Gil , Qiu Feng , Manoragavan Ragavie , Ko Dennis T. , Elbaz‐Greener Gabby , Chung Jennifer C. Y. , Sud Maneesh , Farkouh Michael E. , Madan Mina , Fremes Stephen E. , Wijeysundera Harindra C.
Published: June 2021

Background

The multidisciplinary Heart Team (HT) is recommended for management decisions for transcatheter aortic valve replacement (TAVR) candidates, and during TAVR procedures. Empiric evidence to support these recommendations is limited. We aimed to explore temporal trends, drivers, and outcomes associated with HT utilization.

Methods and Results

TAVR candidates were identified in Ontario, Canada, from April 1, 2012 to March 31, 2019. The HT was defined as having a billing code for both a cardiologist and cardiac surgeon during the referral period. The procedural team was defined as a billing code during the TAVR procedure. Hierarchical logistical models were used to determine the drivers of HT. Median odds ratios were calculated to quantify the degree of variation among hospitals. Of 10 412 patients referred for TAVR consideration, 5489 (52.7%) patients underwent a HT during the referral period, with substantial range between hospitals (median odds ratio of 1.78). Utilization of a HT for TAVR referrals declined from 69.9% to 41.1% over the years of the study. Patient characteristics such as older age, frailty and dementia, and hospital characteristics including TAVR program size, were found associated with lower HT utilization. In TAVR procedures, the procedural team included both cardiologists and cardiac surgeons in 94.9% of cases, with minimal variation over time or between hospitals.

Conclusions

There has been substantial decline in HT utilization for TAVR candidates over time. In addition, maturity of TAVR programs was associated with lower HT utilization.
‘Guilty of Having Been Obedient’
Authors: Owusu Emmanuel Sarpong
Published: June 2021

One of the most debated subjects among academics and experts in the fields of International Humanitarian Law and International Criminal Law is the principle of individual criminal responsibility for war crimes. Even more contentious is that aspect of the principle relating to crimes committed under superior orders – a legal strategy employed by many defendants at the Nuremberg war crimes trials. This paper contributes to the debate by establishing the extent to which Article 33 of the Rome Statute, which adopts the conditional liability approach, is justified. The article achieves its objective by critically discussing the subject from a combination of legal, psychological and moral philosophical perspectives. It presents a historical account of the superior orders defence, highlighting how two conflicting liability doctrines, absolute liability and conditional liability, have traditionally been applied by the courts, and taking a stance in favour of the latter. The article, however, underlines some pressing questions that Article 33 raises. It offers a brief exegesis of the emotion of fear to show how it may destroy voluntariness, arguing that as a modifier of voluntariness, grave fear, in certain circumstances, should exculpate perpetrators in claims of crime under superior orders, even where the orders were manifestly unlawful.
The Narrowing of the European Court of Human Rights? Legal Diplomacy, Situational Self-Restraint, and the New Vision for the Court
Authors: Madsen Mikael Rask
Published: June 2021

In recent years, the European Court of Human Rights (ECtHR) has faced a growing number of challenges, stemming, among other reasons, from problems with the implementation of some of its judgments, an upsurge of sovereigntist sentiments in some member states, and the rise of de facto illiberal democracies within its jurisdiction. This article examines the effects that these changing contexts have had on the operation of the ECtHR. In very general terms, the article finds that the ECtHR has become increasingly more restrained, but that this restraint plays out in multiple different ways which reflect the structural differences among the member states with regard to the protection of human rights. The article argues that the ECtHR has developed a new and differentiated legal rationality that combines elements of its original legal diplomacy with new forms of self-restraint and a new, revised vision for its overarching role in the protection of European human rights. The overall result is a narrowing of the role of the Court.
Using the Comparative Method in Democratic Theory: A Solution to the “File Drawer Problem”?
Authors: Dimova Gergana
Published: June 2021

There are currently dozens of conceptions in democratic theory of what constitutes democratic progress and even more concepts of the crisis of democracy. This plethora of ideas is both good news and bad news. The boom in theorizing means that specializations have allowed political scientists to fine-tune their in-depth analysis in order to capture smaller and more specific movements of democratic progress and regress. But the multiplicity of models of the crisis and transformation of democracy also spells some bad news, which is far less often acknowledged and far less understood. This article seeks to shed light on the dangers of not comparing and integrating various models of democracy and to extrapolate the benefits of using the comparative method to do so.
Bioinformatics Analysis of Dysregulated MicroRNA-Messenger RNA Networks in Small Cell Lung Cancer
Authors: Liu Xingsheng , Zhang Yi
Published: June 2021

The present study aimed to identify a key module of differentially expressed miRNAs (DE-miRNAs) together with the corresponding differentially expressed mRNAs (DE-mRNAs) within small cell lung cancer (SCLC). Linear models were applied to ascertain the DE-miRNAs and DE-mRNAs in SCLC
versus matched non-carcinoma samples obtained from the RNA expression datasets of GSE19945, GSE74190 and GSE6044. The common DE-miRNAs were identified using the Venn plot. Then, 3 databases were used to retrieve the DE-miRNAs target genes, and the intersection was taken for validating the
shared target genes. Besides, Cytoscape was utilized for constructing the miRNAmRNA network for SCLC. Finally, a key module of five DE-miRNAs and four hub genes was determined based on the degree. In addition, the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses
were conducted for exploring those hub genes in terms of their functions along with the involved signal transduction pathways. Altogether 106 shared DE-miRNAs were identified, which were used to predict 63 common target genes. In addition, a key module of five DE-miRNAs (hsa-miR-17-5p, hsa-miR-20a-5p,
hsa-miR-20b-5p, hsa-miR-93-5p and hsa-miR- 106b-5p) and four hub genes (SOX4, DPYSL2, TGFBR2 and F3) were extracted from the miRNAmRNA network according to their degree. Finally, the hub genes were subjected to GO as well as KEGG analysis, which revealed that cell cycle G1/S phase transition,
the extracellular matrix, and cellular senescence signaling pathways exerted vial parts during SCLC progression. A key module of five DE-miRNAs and four hub genes may be potentially used as clinical biomarkers to predict SCLC.
Mechanism of Dandelion Sterol in Treating Pulmonary Fibrosis Through Transforming Growth Factor-β Signaling Pathway
Authors: Lv Qun , Wang Jianjun , Ruan Zhaoyang
Published: June 2021

Background: The paper aimed to elucidate the molecular mechanism of Dandelion sterol in the treatment of pulmonary fibrosis, to study its effect on EMT of lung epithelial cells, and to find its target and downstream signaling pathways. Material and methods: The effects
of Dandelion sterol on parathyroid (PQ)-induced EMT in lung epithelial cells were studied by immunofluorescence method. Immunohistochemistry and western-blot methods were used to verify that Dandelion sterol inhibited TGF-β1-induced EMT at the cellular level in animals, demonstrating
that Dandelion sterol targets TGF-β1 to exert an anti-pulmonary fibrosis effect. Results: Dandelion sterol significantly inhibited PQ-induced migration and invasion of lung epithelial cells, and also inhibited the induced EMT. Dandelion sterol had a proper binding activity with
the lung fibrosis-inducing factor TGF-β1. Dandelion sterol inhibited the TGF-β1-induced EMT process, and acted to treat pulmonary fibrosis by inhibiting the TGF-β1/Smad3 signaling pathway. Conclusion: Dandelion sterol can inhibit the pulmonary fibrosis by inhibiting the
EMT process of lung epithelial cells through targeting the TGF- β1/Smad signaling pathway.
Effect of Substance P on Differentiation of Bone Marrow Stromal Stem Cells Under Oxidative Stress
Authors: Song Wei , Wang Jun , Zhang Yumin , Ma Tao , Wang Kunzheng
Published: June 2021

Bone marrow stromal stem cells (BMSCs) can be used to treat bone defects but BMSCs are damaged under oxidative stress. The neuropeptide substance P (SP) involves various cellular activities. However, SP’s role in BMSCs differentiation under oxidative stress is unknown. Rat BMSCs
were isolated and assigned into control group; oxidative stress group treated with 200 μM H2O2; and SP group, in which 10 mM SP was added under oxidative stress followed by analysis of SP secretion by ELISA, cell proliferation by MTT method, Caspase3 activity, Bax
and Bcl-2 level by Real time PCR, ALP activity ROS and SOD content as well as NF-κB level by Western blot. Under oxidative stress, SP secretion was significantly decreased, BMSCs proliferation was inhibited, Caspase3 activity and Bax expression increased, Bcl-2 and ALP activity was decreased
along with increased ROS activity and NF-κB level and reduced SOD activity (P <0.05), adding SP to BMSCs under oxidative stress can significantly promote SP secretion and cell proliferation, reduce Caspase3 activity and Bax expression, increase Bcl-2 expression and ALP activity,
decreased ROS activity and NF-κB level, and elevated SOD activity (P <0.05). SP secretion from BMSCs cells was reduced under oxidative stress. Up-regulation of SP in BMSCs cells under oxidative stress can inhibit BMSCs apoptosis and promote cell proliferation and osteogenesis
by regulating NF-κB.
Protective Effect of MicroRNA-23b on Kidney Injury in Septic Rats Through Regulation of Mothers Against Decapentaplegic Homolog 3 (Smad3)
Authors: Bai Yanlou , Liu Yuan , Jiang Suwen
Published: June 2021

Our study aims to investigate the mechanism whereby microRNA (miRNA)-23b alleviates kidney damage in septic rats. Herein, we set up septic rat model, control group and sham-operated model to evaluate the kidney tissue damage. The glomerular mesangial cells isolated from rats were transfected
with plasmids expressing miR-23b followed by analysis of the expression of miR-23b, Smad3, TLR4, HMGB1 and expression of autophagy-related proteins (LC3, beclin-1) by western blot and RT-qPCR. The level of TNF-α, IL-6 and BUN and SCr were significantly elevated in the model group and
decreased after overexpression of miR-23b with elevated LC3-II, Smad3 and Beclin-1 expression. miR-23b mimic group presented highest expression of miR-23b, followed by miR-23b NC group, and miR-23b inhibitor group. The levels of TLR4, and HMGB1 and positive rate of NF-κBp65 in miR-23b
mimic group were significantly lower than those in miR-23b inhibitor group (p < 0.05). Importantly, miR-23b has a targeted relationship with Smad3. Overexpression of miR- 23b induces autophagy by promoting the Smad3 expression, alleviates kidney damage in septic rats, and reduces
inflammation and inactivates NF-κB signaling pathway.
Seamless Detection of Cutoff Lows and Preexisting Troughs
Authors: Kasuga Satoru , Honda Meiji , Ukita Jinro , Yamane Shozo , Kawase Hiroaki , Yamazaki Akira
Published: June 2021

We propose a new scheme based on geopotential height fields to detect cutoff lows starting in the preexisting trough stage. The intensity and scale derived from the proposed scheme will allow for a better understanding of the cutoff low life cycle. These cutoff lows often accompany mesoscale disturbances, causing adverse weather-related events, such as intense torrential rainfall and/or tornadoes. The proposed scheme quantifies the geometric features of a depression from its horizontal height profile. The height slope of a line intersecting the depression bottom and the nearest tangential point (optimal slope) locally indicates the intensity and scale of an isolated depression.

The strength of the proposed scheme is that, by removing a local background height slope from a geopotential height field, the cutoff low and its preexisting trough are seamlessly detected as an identical depression. The distribution maps for the detected cutoff lows and preexisting troughs are illustrated along with their intensities, sizes, and local background flows estimated from snapshot height fields. We conducted climatological comparisons of cutoff lows to determine the utility of the proposed scheme.
Miigwech and blood memory: gratitude as a multi-lineage spiritual practice
Authors: Raining Hillary
Published: June 2021

In the last few years, scientists have discovered what indigenous communities have known for countless generations: that the emotional and physical lives of our ancestors will fundamentally affect our emotional and physical lives as well. Despite the increasingly evident effect that both trauma and/or gratitude can have on an individual (and by extension their offspring), there has been precious little research done on the effects of gratitude on future generations. This paper will seek to study the effect of gratitude as a deep spiritual practice that changes—not only those who practice it—but also the generations that follow. It will do so through the lenses of generational, psychological, and theological studies using the gratitude worldview and practices of the Ojibwa Native Americans as our entry point into the study of blood memory. It will also offer suggestions for church communities looking to reclaim gratitude as a spiritual practice in modern times drawing from the Church’s institutional “blood memory.”
Beyond convergence and divergence: Towards a ‘both and’ approach to critical race and critical Indigenous studies in Australia
Authors: Bargallie Debbie , Lentin Alana
Published: June 2021

Although the study of race in relation to both settler colonialism, and Indigeneity and Indigenous sovereignty is insufficiently supported by sociology and the social sciences in Australia as elsewhere, scholars are exploring the synergetic possibilities between critical race and decolonial, Indigenous-centred approaches to theorizing the racial state. Nevertheless, some scholars have argued that the critical race toolbox is insufficient for making sense of how race is produced, reproduced and maintained in settler colonial states. Contributing to this critical discussion, this article explores the conceptual, empirical and practical relationship between race, Indigeneity and Indigenous sovereignty as lenses to examine racism, antiracism and Indigenous self-determination as interrelated, but discrete, issues. In particular, via a discussion of the concept of ‘interest convergence’, the article examines the synergetic possibilities of Critical Race Theory (CRT) and Critical Indigenous theories and methodologies. The authors conclude that rather than ‘throwing the baby out with the bathwater’ by jettisoning CRT, we should work to deepen and broaden scholarship that connects race, Indigeneity and Indigenous sovereignty in ways that benefit both local and global understandings of the many and complex workings of race.
Reimagining the World Bank: Global Public Goods in an Age of Crisis
Authors: Kopiński Dominik , Wróblewski Marek
Published: June 2021

For some time now, there has been a push for the World Bank to shift its focus toward global public goods (GPGs). These are goods that, once delivered, can be unrestrictedly consumed by most—if not all—countries on the planet. Nor are their benefits rivalrous. Moreover, the production of GPGs cannot be left to markets or individual countries, as these have suboptimal incentives to act. In the wake of the COVID‐19 outbreak, the concept of GPGs has seen a revival of sorts, with the pandemic not only striking just as multilateralism was at its lowest ebb, but also serving as irrefutable proof that the world needs international collaboration now more than ever. Multilateral institutions, and in particular the World Bank—a leading global institution with global membership—can rightfully be regarded as a possible solution to many global challenges. Based on interviews conducted with World Bank senior staff, as well as numerous experts, this article discusses arguments in favor of such a strategic shift. While there are legitimate claims for the Bank becoming a full‐fledged provider of GPGs, the institution's historical roots and operational constraints make this an unlikely prospect.
Attrition as a bottom-up pathway to subnational democratization
Authors: van Mierlo Trix
Published: June 2021

Oftentimes, democracy is not spread out evenly over the territory of a country. Instead, pockets of authoritarianism can persist within a democratic system. A growing body of literature questions how such subnational authoritarian enclaves can be democratized. Despite fascinating insights, all existing pathways rely on the actions of elites and are therefore top-down. This article seeks to kick-start the discussion on a bottom-up pathway to subnational democratization, by proposing the attrition mechanism. This mechanism consists of four parts and is the product of abductive inference through theory-building causal process tracing. The building blocks consist of subnational democratization literature, social movement theory, and original empirical data gathered during extensive field research. This case study focuses on the ‘Dynasty Slayer’ in the province of Isabela, the Philippines, where civil society actors used the attrition mechanism to facilitate subnational democratization. This study implies that civil society actors in subnational authoritarian enclaves have agency.
Feasibility and Acceptability of a mHealth Self-Management Intervention for Pediatric Transplant Families
Authors: Lerret Stacee M. , Schiffman Rachel , White-Traut Rosemary , Medoff-Cooper Barbara , Ahamed Sheikh Iqbal , Adib Riddhiman , Liegl Melodee , Alonso Estella , Mavis Alisha , Jensen Kyle , Peterson Caitlin G. , Neighbors Katie , Riordan Mary K , Semp Melissa C. , Vo Truc , Stendahl Gail , Chapman Shelley , Unteutsch Rachel , Simpson Pippa
Published: June 2021

Families of pediatric solid organ transplant recipients need ongoing education and support in the first 30 days following hospital discharge for the transplantation. The purpose of this report is to describe the feasibility, acceptability, and preliminary efficacy of a mHealth family-self management intervention, ( myFAMI), designed to improve post-discharge outcomes of coping, family quality of life, self-efficacy, family self-management, and utilization of health care resources. We enrolled 46 primary family members. myFAMI was feasible and acceptable; 81% (n=17/21) of family members completed the app at least 24/30 days (goal 80% completion rate). Family members generated 134 trigger alerts and received a nurse response within the goal timeframe of < 2 h 99% of the time. Although there were no significant differences between groups, primary outcomes were in the expected direction. The intervention was well received and is feasible for future post-discharge interventions for families of children who receive an organ transplant.
Otolaryngology Manifestations of Primary Ciliary Dyskinesia: A Multicenter Study
Authors: Zawawi Faisal , Shapiro Adam J. , Dell Sharon , Wolter Nikolaus E. , Marchica Cinzia L. , Knowles Michael R. , Zariwala Maimoona A. , Leigh Margaret W. , Smith Mariana , Gajardo Pilar , Daniel Sam J.
Published: June 2021

Objective

This project aims to prospectively and objectively assess otolaryngological manifestations and quality of life of children with primary ciliary dyskinesia (PCD) and compare these findings with healthy pediatric controls.

Study Design

Cross‐sectional.

Setting

Two high‐volume pediatric PCD specialty centers.

Methods

Standardized clinical assessment; Sino‐Nasal Outcome Test 22 (SNOT‐22); Hearing Environment and Reflection Quality of Life (HEAR‐QL); Reflux Symptom Index (RSI); standardized physical examination of the sinonasal, laryngeal, and otological systems; and investigations including pure‐tone audiograms (PTAs) and sinonasal cultures were collected.

Results

Forty‐seven children with PCD and 25 control participants were recruited. Children with PCD had more upper airway symptoms than healthy children. They had significantly higher scores in both SNOT‐22 and RSI, indicating worse sinonasal and reflux symptoms, with worse quality of life on the HEAR‐QL index compared to healthy children (P<. 05). Fifty‐two percent of children with PCD‐related hearing loss were not aware of their hearing deficit that was present on audiological assessment, and only 23% of children who had ventilation tubes had chronic otorrhea, most of which was easily controlled with ototopic drops. Furthermore, although all children with PCD had chronic rhinosinusitis, only 36% of them were using topical nasal treatment. The most common bacteria cultured from the middle meatus wereStaphylococcus aureusin 11 of 47 (23%), followed byStreptococcus pneumoniaein 10 of 47 (21%).

Conclusion

This multisite cohort highlights the importance of otolaryngology involvement in the management of children with PCD. More rigorous otolaryngological management may lead to reductions in overall morbidity and improve quality of life for children with PCD.
Clinical features and outcomes of metastatic bone tumors of the pelvis
Authors: Yang Qing , Chen Nong , Fu Wenqin
Published: June 2021

Objective

The number of patients with metastatic bone tumors of the pelvis (MBTP) has increased, and the risk of metastasis and recurrence in the pelvic bones is difficult to assess. Therefore, we investigated the clinical features and oncological outcomes of patients with MBTP.

Methods

We analyzed the clinical features and oncological outcomes of MBTP in 72 patients (42 men, 30 women; mean age, 50.5 years) from 2008 to 2017. Recurrence in the pelvic bones and survival rates were analyzed with regard to patients’ potential contributing factors.

Results

Enneking region I was the area most commonly containing MBTP (47.3%). Low- and high-grade tumors were identified in 40 and 32 patients, respectively. The most common pathological type was adenomatous carcinoma (34.7%), and the most common primary lesion was lung cancer (20.8%). The 3-year overall recurrence rate within the pelvic bones was 34.7%, and the 5-year overall survival rate was 29.2%.

Conclusion

Patients with MBTP have a high risk of recurrence in the pelvic bones and poor survival after multimodal treatment. Pelvic recurrence might be affected by the metastatic involvement, tumor grade, surgical margins, and type of surgery, whereas the survival rate tends to be associated with the tumor grade.
Outcomes of Arthroscopic Nerve Release in Patients Treated for Large or Massive Rotator Cuff Tears and Associated Suprascapular Neuropathy: A Prospective, Randomized, Double-Blinded Clinical Trial
Authors: Sachinis Nikolaos Platon , Papagiannopoulos Sotirios , Sarris Ioannis , Papadopoulos Pericles
Published: June 2021

Background:

Suprascapular neuropathy has been observed in the setting of rotator cuff tears (RCTs), but its association with these tears and their treatment are unclear.

Hypothesis:

Arthroscopic suprascapular nerve release during rotator cuff repair will not alter the outcomes of neuropathy.

Study Design:

Randomized controlled trial; Level of evidence, 1.

Methods:

A total of 42 patients with large/massive reparable RCTs and suprascapular neuropathy were recruited and followed up at 6 and 12 months. Electrophysiological results as well as Disabilities of the Arm, Shoulder and Hand (DASH), American Shoulder and Elbow Surgeons (ASES), and Constant scores were evaluated at selected time periods. Patients were randomly assigned to 2 groups. Patients in the control group underwent arthroscopic repair of the rotator cuff without combined arthroscopic release of the superior transverse scapular ligament; in the second group, the superior transverse ligament was released. The primary outcome was to examine full suprascapular nerve recovery through electrophysiological changes between groups. The secondary/tertiary outcomes were analysis of clinical outcomes and assessment of the relation between RCT size and the degree of suprascapular nerve recovery. Patients, clinical staff members, and the neurologist were blinded to the type of surgical procedure.

Results:

Of 42 patients, 37 completed the follow-up at 12 months (median age, 64 years [range, 50-75 years]). Overall, 17 of 19 (89.5%) patients in the control group and 15 of 18 (83.3%) patients in the nerve release group had full nerve recovery, with no significant difference between the 2 groups. Clinically, all patients in both groups showed a significant improvement ( P < .001), but no significant difference was observed between the 2 groups in terms of 12-month postoperative scores (control group: DASH: median, 5 [range, 0-21]; ASES: median, 88 [range, 83-98]; Constant: median, 86 [range, 70-98]) (nerve release group: DASH: median, 6 [range, 0-25]; ASES: median, 90 [range, 83-98]; Constant: median, 88 [range, 75-98]). Also, no significant difference was found between the 2 groups regarding other secondary and tertiary outcomes.

Conclusion:

Combined arthroscopic release of the superior transverse scapular ligament and rotator cuff repair in patients with large/massive RCTs and suprascapular neuropathy did not produce statistically significant improved outcomes compared with repair of the rotator cuff alone.

Registration:

NCT02318381 (ClinicalTrials.gov identifier).