bluuebunny/crossref_metadata_2025 huggingface dataset:
Is the percentage of hormone receptor positivity in HR+ HER2-metastatic breast cancer patients receiving CDK 4/6 inhibitor with endocrine therapy predictive and prognostic?
Authors: Keskinkilic Merve , Semiz Huseyin Salih , Yavuzsen Tugba , Oztop Ilhan
Published: June 2024

Purpose

There is no clear information in the literature about the relationship between the efficacy of CDK 4/6i combined with ET and HR positivity. However, we know that the longest overall survival was in the ER-strong positive/PR intermediate or strong positive groups. Therefore, we aimed to investigate CDK4/6i treatments that create positivity in HR.

Methods

Patients with the diagnosis of HR+/HER2- MBC who were treated with CDK 4/6i and HR >10% were retrospectively evaluated. To analyze the role of HR positivity, ER was moderately positive (10-49%) and ER was strongly positive (50-100%); PR was grouped as moderately positive (10-49%) and PR strongly positive (50-100%).

Results

Median follow-up of 150 patients included in the study was 15.2 months (95% CI, 2.1-40.9 months). The highest response in the whole group was obtained in the ER-strong positive/PR moderate or strong positive group, and the ER moderate positive/PR moderate or strong group. This was followed by the ER strong positive/PR negative group, and then the ER moderate positive/PR negative group. Although these advantages were not statistically significant, they were numerically higher (ORR: 83.8% vs. 83.3% vs. 77.4% vs. 62.5%, p=0.488, respectively). The highest survival in the whole group was achieved in the ER strong positive/PR moderate or strongly positive group, followed by the ER moderately positive/PR moderate or strongly positive group, the ER strongly positive/PR negative group followed by the ER moderate positive/PR negative group, respectively(p=0.410). However, these advantages were not statistically significant.

Conclusion

As a result, HR+/HER2- MBC patients receiving CDK 4/6i combined with ET suggest that the percentage of HR positivity may have a predictive and prognostic role.
Evaluation of pathogenic variants detected in high homology regions of the PMS2 gene. How effective is long-range PCR?
Authors: Paixão Daniele , Lima Thalitta Hetamaro Ayala , de Souza Rafaela Rogério Floriano , Carnavalli Juliana Emilia Prior , Picanço-Albuquerque Clarissa Gondim , Silva-Fernandes Isabelle Joyce de Lima , de Barros Silva Paulo Goberlânio , Mitne-Neto Miguel , Moreira Caroline Mônaco , Baratela Wagner Antônio da Rosa
Published: June 2024

Introduction

Lynch syndrome (LS) is an inherited cancer predisposition syndrome characterized by a high risk of colorectal and extracolonic tumors. Germline pathogenic variants (GPV) in the PMS2 gene are associated with <15% of all cases. The PMS2CL pseudogene presents high homology with PMS2, challenging molecular diagnosis by next-generation sequencing (NGS). Due to the high methodological complexity required to distinguish variants between PMS2 and PMS2CL, most laboratories do not clearly report the origin of this molecular finding.

Objective

The aim of this study was to confirm the GPVs detected by NGS in regions of high homology segments of the PMS2 gene in a Brazilian sample.

Methods

An orthogonal and gold standard long-range PCR (LR-PCR) methodology to separate variants detected in the PMS2 gene from those detected in the pseudogene.

Results

A total of 74 samples with a PMS2 GPV detected by NGS in exons with high homology with PMS2CL pseudogene were evaluated. The most common was NM_000535.6:c.2182_2184delinsG, which was previously described as deleterious mutation in a study of African-American patients with LS and has been widely reported by laboratories as a pathogenic variant associated with the LS phenotype. Of all GPVs identified, only 6.8% were confirmed by LR-PCR. Conversely, more than 90% of GPV were not confirmed after LR-PCR, and the diagnosis of LS was ruled out by molecular mechanisms associated with PMS2.

Conclusion

In conclusion, the use of LR-PCR was demonstrated to be a reliable approach for accurate molecular analysis of PMS2 variants in segments with high homology with PMS2CL. We highlight that our laboratory is a pioneer in routine diagnostic complementation of the PMS2 gene in Brazil, directly contributing to a more assertive molecular diagnosis and adequate genetic counseling for these patients and their families.
Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model
Authors: Budhu Sadna , Kim Kwanghee , Yip Wesley , La Rosa Stephen , Jebiwott Sylvia , Cai Liqun , Holland Aliya , Thomas Jasmine , Preise Dina , Somma Alex , Gordon Benjamin , Scherz Avigdor , Wolchok Jedd D. , Erinjeri Joseph , Merghoub Taha , Coleman Jonathan A.
Published: June 2024

Introduction

Immunotherapy is revolutionizing the management of multiple cancer types. However, only a subset of patients responds to immunotherapy. One mechanism of resistance is the absence of immune infiltrates within the tumor. In situ vaccine with local means of tumor destruction that can induce immunogenic cell death have been shown to enhance tumor T cell infiltration and increase efficacy of immune checkpoint blockade.

Methods

Here, we compare three different forms of localize tumor destruction therapies: radiation therapy (RT), vascular targeted photodynamic therapy (VTP) and cryoablation (Cryo), which are known to induce immunogenic cell death, with their ability to induce local and systemic immune responses in a mouse 4T1 breast cancer model. The effects of combining RT, VTP, Cryo with anti-PD1 was also assessed.

Results

We observed that RT, VTP and Cryo significantly delayed tumor growth and extended overall survival. In addition, they also induced regression of non-treated distant tumors in a bilateral model suggesting a systemic immune response. Flow cytometry showed that VTP and Cryo are associated with a reduction in CD11b+ myeloid cells (granulocytes, monocytes, and macrophages) in tumor and periphery. An increase in CD8+ T cell infiltration into tumors was observed only in the RT group. VTP and Cryo were associated with an increase in CD4+ and CD8+ cells in the periphery.

Conclusion

These data suggest that cell death induced by VTP and Cryo elicit similar immune responses that differ from local RT.
Integrating Chinese medicine into mainstream cancer therapies: a promising future
Authors: Ni Baoyi , Xue Kaiyuan , Wang Jia , Zhou Jilai , Wang Lankang , Wang Xinmiao , Liu Ting , Ye Naijing , Jiang Jiakang
Published: June 2024

Malignant tumors are complex systemic chronic diseases and one of the major causes of human mortality. Targeted therapy, chemotherapy, immunotherapy, and radiotherapy are examples of mainstream allopathic medicine treatments that effective for intermediate and advanced malignant tumors. The ongoing use of conventional allopathic medicine has resulted in adverse responses and drug resistance, which have hampered its efficacy. As an important component of complementary and alternative medicine, Chinese medicine has been found to have antitumor effects and has played an important role in enhancing the therapeutic sensitivity of mainstream allopathic medicine, reducing the incidence of adverse events and improving immune-related functions. The combined application of adjuvant Chinese medicine and mainstream allopathic medicine has begun to gain acceptance and is gradually used in the field of antitumor therapy. Traditional natural medicines and their active ingredients, as well as Chinese patent medicines, have been proven to have excellent therapeutic efficacy and good safety in the treatment of various malignant tumors. This paper focuses on the mechanism of action and research progress of combining the above drugs with mainstream allopathic medicine to increase therapeutic sensitivity, alleviate drug resistance, reduce adverse reactions, and improve the body’s immune function. To encourage the clinical development and use of Chinese herb adjuvant therapy as well as to provide ideas and information for creating safer and more effective anticancer medication combinations, the significant functions of Chinese herb therapies as adjuvant therapies for cancer treatment are described in detail.
A review of common influencing factors and possible mechanisms associated with allergic diseases complicating tic disorders in children
Authors: Zhang Panpan , Zheng Zhimin , Sun Hao , Gao Tieying , Xiao Xuwu
Published: June 2024

Over the past few decades, the incidence of childhood allergic diseases has increased globally, and their impact on the affected child extends beyond the allergy itself. There is evidence of an association between childhood allergic diseases and the development of neurological disorders. Several studies have shown a correlation between allergic diseases and tic disorders (TD), and allergic diseases may be an important risk factor for TD. Possible factors influencing the development of these disorders include neurotransmitter imbalance, maternal anxiety or depression, gut microbial disorders, sleep disturbances, maternal allergic status, exposure to tobacco, and environmental factors. Moreover, gut microbial disturbances, altered immunological profiles, and DNA methylation in patients with allergic diseases may be potential mechanisms contributing to the development of TD. An in-depth investigation of the relationship between allergic diseases and TD in children will be important for preventing and treating TD.
The effect of exogenous melatonin on waterlogging stress in Clematis
Authors: Chen Kai , Hu Qingdi , Ma Xiaohua , Zhang Xule , Qian Renjuan , Zheng Jian
Published: June 2024

Clematis is the queen of the vines, being an ornamental plant with high economic value. Waterlogging stress reduces the ornamental value of the plant and limits its application. Melatonin plays an important role in plant resistance to abiotic stresses. In this study, the physiological responses and gene expression levels of two wild species, namely, Clematis tientaiensis and Clematis lanuginosa, and two horticultural varieties, namely, ‘Sen-No-Kaze’ and ‘Viva Polonia,’ under waterlogging stress were analyzed to determine the effect of melatonin on waterlogging tolerance. The results showed that the waterlogging tolerances of C. lanuginosa and ‘Sen-No-Kaze’ were relatively poor, but were significantly improved by concentrations of 100 μmol·L-1 and 50 μmol·L-1 melatonin. C. tientaiensis and ‘Viva Polonia’ had relatively strong tolerance to waterlogging, and this was significantly improved by 200 μmol·L-1 melatonin. Under waterlogging stress, the relative conductivity and H2O2 content of Clematis increased significantly; the photosynthetic parameters and chlorophyll contents were significantly decreased; photosynthesis was inhibited; the contents of soluble protein and soluble sugars were decreased. Effective improvement of waterlogging tolerance after exogenous melatonin spraying, the relative conductivity was decreased by 4.05%-27.44%; the H2O2 content was decreased by 3.84%-23.28%; the chlorophyll content was increased by 35.59%-103.36%; the photosynthetic efficiency was increased by 25.42%-45.86%; the antioxidant enzyme activities of APX, POD, SOD, and CAT were increased by 28.03%-158.61%; the contents of proline, soluble protein, and soluble sugars were enhanced, and cell homeostasis was improved. Transcription sequencing was performed on wild Clematis with differences in waterlogging tolerance, and nine transcription factors were selected that were highly correlated with melatonin and that had the potential to improve waterlogging tolerance, among which LBD4, and MYB4 were significantly positively correlated with the antioxidant enzyme system, and bHLH36, DOF36, and WRKY4 were significantly negatively correlated. Photosynthetic capacity was positively correlated with DOF36 and WRKY4 while being significantly negatively correlated with MYB4, MOF1, DOF47, REV1 and ABR1. Melatonin could enhance the flooding tolerance of Clematis by improving photosynthetic efficiency and antioxidant enzyme activity. This study provides an important basis and reference for the application of melatonin in waterlogging-resistant breeding of Clematis.
UV light and adaptive divergence of leaf physiology, anatomy, and ultrastructure drive heat stress tolerance in genetically distant grapevines
Authors: Fernandes de Oliveira Ana , Piga Giovanni Kamal , Najoui Soumiya , Becca Giovanna , Marceddu Salvatore , Rigoldi Maria Pia , Satta Daniela , Bagella Simonetta , Nieddu Giovanni
Published: June 2024

The genetic basis of plant response to light and heat stresses had been unveiled, and different molecular mechanisms of leaf cell homeostasis to keep high physiological performances were recognized in grapevine varieties. However, the ability to develop heat stress tolerance strategies must be further elucidated since the morpho-anatomical and physiological traits involved may vary with genotype × environment combination, stress intensity, and duration. A 3-year experiment was conducted on potted plants of Sardinian red grapevine cultivars Cannonau (syn. Grenache) and Carignano (syn. Carignan), exposed to prolonged heat stress inside a UV-blocking greenhouse, either submitted to low daily UV-B doses of 4.63 kJ m−2 d−1 (+UV) or to 0 kJ m−2 d−1 (−UV), and compared to a control (C) exposed to solar radiation (4.05 kJ m−2 d−1 average UV-B dose). Irrigation was supplied to avoid water stress, and canopy light and thermal microclimate were monitored continuously. Heat stress exceeded one-third of the duration inside the greenhouse and 6% in C. In vivo spectroscopy, including leaf reflectance and fluorescence, allowed for characterizing different patterns of leaf traits and metabolites involved in oxidative stress protection. Cannonau showed lower stomatal conductance under C (200 mmol m−2 s−1) but more than twice the values inside the greenhouse (400 to 900 mmol m−2 s−1), where water use efficiency was reduced similarly in both varieties. Under severe heat stress and −UV, Cannonau showed a sharper decrease in primary photochemical activity and higher leaf pigment reflectance indexes and leaf mass area. UV-B increased the leaf pigments, especially in Carignano, and different leaf cell regulatory traits to prevent oxidative damage were observed in leaf cross-sections. Heat stress induced chloroplast swelling, plastoglobule diffusion, and the accumulation of secretion deposits in both varieties, aggravated in Cannonau −UV by cell vacuolation, membrane dilation, and diffused leaf blade spot swelling. Conversely, in Carignano UV-B, cell wall barriers and calcium oxalate crystals proliferated in mesophyll cells. These responses suggest an adaptive divergence among cultivars to prolonged heat stress and UV-B light. Further research on grapevine biodiversity, heat, and UV-B light interactions may give new insights on the extent of stress tolerance to improve viticulture adaptive strategies in climate change hotspots.
Playing with data differently: engaging with autism and gender through participatory arts/music and a performative framework for analysis
Authors: Shaughnessy Nicola , Herbert Ruth , Williams Emma , Walduck Jackie , von Jungenfeld Rocio , Newman Hannah
Published: June 2024

There are increasing demands for Participatory Arts-Based (PAB) programs involved in health research to better evidence outcomes using robust quantitative evaluation methodologies taken from science, such as standardized questionnaires, to inform commissioning and scale-up decisions. However, for PAB researchers trying to do this, barriers arise from fundamental interdisciplinary differences in values and contexts. Researchers are required to navigate the tensions between the practice-based evidence produced by the arts and the evidence-based practice sought by psychologists. Consequently, there is a need for interdisciplinary arts-science collaborations to produce alternative methods of evaluation that are better aligned to PAB approaches, and which combine systematic rigor with a sensitivity to the values, contexts and strengths of this approach. The current article centers on the development of an alternative transdisciplinary analytic tool, the Participatory arts Play Framework (PP-Framework), undertaken as part of an arts-psychology collaboration for a UK AHRC-funded PAB research project: Playing A/Part: Investigating the identities and experiences of autistic girls. We present details of three stages in the development of the PP-Framework: 1. preliminary emergence of the framework from initial video analysis of observational data from participatory music and sound workshops run for 6 adolescent autistic girls (aged 11–16); 2. identification and application of modes of engagement; and 3. further testing of the framework as an evaluation tool for use in a real-world setting, involving professional musicians engaged in delivery of a creative music project at a center for homeless people. The PP-Framework maps types of participation in terms of performative behaviors and qualities of experience, understood as modes of play. It functions as a vehicle for analyzing participant engagement, providing a tool predicated on the processes of working in creative participatory contexts while also being sensitive to the esthetic qualities of what is produced and capable of capturing beneficial changes in engagement. It offers a conceptual approach for researchers to undertake observation of participatory arts practices, taking account of embodied engagement and interaction processes. It is informed by understandings of autistic performativity and masking in conjunction with an ecological understanding of sense making as being shaped by environments, social relations and sensing subjectivity. The framework has the potential to be a bi-directional tool, with application for both practitioners and participants.
In what ways does placeness affect people’s behavior? Focusing on personal place attachment and public place image as connecting parameter
Authors: Dalavong Phengsy , Im Ha Na , Choi Chang Gyu
Published: June 2024

Placeness is believed to play a significant role in enhancing the well-being and place-use of individuals, contributing profoundly to how spaces are experienced and interacted with. Despite its perceived importance, there is ongoing debate and insufficient clarity about how exactly placeness influences people’s behavior. This study aims to bridge this gap by theorizing and investigating the pathways from placeness to people’s behavioral intentions, emphasizing the roles of personal place attachment and public place image as pivotal mediators in this relationship. To explore these dynamics, we conducted a survey in Japan, examining the complex interplay between placeness and behavioral intentions, given their rich cultural heritage and modern urban pressures. We employed the Partial Least Squares Structural Equation Modeling (PLS-SEM) approach for path analysis. The analysis suggests that placeness influences behavioral intention through personal place attachment. While placeness does affect public place image, this public image does not have an impact on behavioral intention. The results demonstrated that an individual’s activities, experiences, and cognition of a place are significant factors in creating the intention to engage in word-of-mouth, recommendation, and revisiting behaviors. Policymakers, urban planners, and designers need to understand how to foster people’s behavioral intentions when creating a place imbued with placeness.
From athletic excellence to academic influence: a study of retired Chinese athletes transitioning into the higher education sector
Authors: Zhou Yutao , Zhang Zhiming
Published: June 2024

While the career transition of athletes has been explored to several extents, it is often marked by complex psychosocial challenges and requires a redefined sense of identity and professional purpose. Research to date has predominately focused on the disadvantages or inequity emerging from broad social demographics without delving into specific career transition pathways, such as into higher education settings. This study specifically investigates the unique psychosocial factors underlying the career transition of retired Chinese athletes into higher education. We conducted an interview phase with retired Chinese athletes (Phase 1, n = 17) and a Delphi phase with senior human resources (HR) managers from Chinese higher education settings (Phase 2, n = 15). This approach allowed us to understand the lived experiences and challenges of these athletes within the Chinese cultural and social context, as well as HR experts’ perceptions of their career transitions, respectively. The results unveil crucial psychosocial factors that motivate, and the barriers that challenge, and difficulties retired Chinese athletes in their transition, informing intervention and policy efforts to facilitate their successful integration into higher education.
Hospital accreditation in Mexico fails to improve the quality of healthcare: lessons from an impact evaluation
Authors: Gutiérrez Juan Pablo , Rodriguez Miguel Angel , Torres-Pereda Pilar , Reyes-Morales Hortensia
Published: June 2024

Healthcare quality in low- and middle-income countries poses a significant challenge, contributing to heightened mortality rates from treatable conditions. The accreditation of health facilities was part of the former health reform in Mexico, proposed as a mechanism to enhance healthcare quality. This study assesses the performance of hospital accreditation in Mexico, utilizing indicators of effectiveness, efficiency, and safety. Employing a longitudinal approach with controlled interrupted time series analysis (C-ITSA) and fixed effects panel analysis, administrative data from general hospitals in Mexico is scrutinized. Results reveal that hospital accreditation in Mexico fails to enhance healthcare quality and, disconcertingly, indicates deteriorating performance associated with increased hospital mortality. Amidst underfunded health services, the implemented accreditation model proves inadequately designed to uplift care quality. A fundamental redesign of the public hospital accreditation model is imperative, emphasizing incentives for structural enhancement and standardized processes. Addressing the critical challenge of improving care quality is urgent for Mexico’s healthcare system, necessitating swift action to achieve effective access as a benchmark for universal healthcare coverage.
ChatGPT: perspectives from human–computer interaction and psychology
Authors: Liu Jiaxi
Published: June 2024

The release of GPT-4 has garnered widespread attention across various fields, signaling the impending widespread adoption and application of Large Language Models (LLMs). However, previous research has predominantly focused on the technical principles of ChatGPT and its social impact, overlooking its effects on human–computer interaction and user psychology. This paper explores the multifaceted impacts of ChatGPT on human–computer interaction, psychology, and society through a literature review. The author investigates ChatGPT’s technical foundation, including its Transformer architecture and RLHF (Reinforcement Learning from Human Feedback) process, enabling it to generate human-like responses. In terms of human–computer interaction, the author studies the significant improvements GPT models bring to conversational interfaces. The analysis extends to psychological impacts, weighing the potential of ChatGPT to mimic human empathy and support learning against the risks of reduced interpersonal connections. In the commercial and social domains, the paper discusses the applications of ChatGPT in customer service and social services, highlighting the improvements in efficiency and challenges such as privacy issues. Finally, the author offers predictions and recommendations for ChatGPT’s future development directions and its impact on social relationships.
Empowering public health: building advanced molecular surveillance in resource-limited settings through collaboration and capacity-building
Authors: Koudokpon Hornel , Lègba Boris , Sintondji Kevin , Kissira Islamiath , Kounou Arielle , Guindo Ibrehima , Koné Kléma Marcel , Abdou Mahamadou , Koné Amadou , Sambou Claire , Bankolé Honoré , Yadouleton Anges , Dougnon Victorien
Published: June 2024

The rapid detection and continuous surveillance of infectious diseases are important components of an effective public health response. However, establishing advanced molecular surveillance systems, crucial for monitoring and mitigating pandemics, poses significant challenges in resource-limited developing countries. In a collaborative effort, research institutions from Benin joined forces with Mali's National Institute of Public Health to implement a state-of-the-art molecular surveillance system in Mali. This approach was characterized by collaboration, multidisciplinarity, and tutoring. Key activities included a comprehensive assessment of infrastructure and human resources through document reviews, interviews, and laboratory visits; the development and validation of Standard Operating Procedures (SOPs) for advanced molecular surveillance following an inclusive approach; capacity-building initiatives for 25 biologists in Mali on sequencing techniques; and international tutoring sessions for eight Malian professionals held in Benin. These collective efforts enabled Mali to establish an advanced molecular surveillance system aligned with the WHO’s global strategy for genomic surveillance. This manuscript aims to share experiences, insights, and outcomes from this initiative, with the hope of contributing to the broader discussion on strengthening global health security through collaborative approaches and capacity-building efforts, particularly in developing countries.
Evaluation of clopidogrel response in healthy cats using a novel viscoelastic test and thromboelastography
Authors: Rosati Tommaso , Jandrey Karl E. , Stern Joshua A. , Nguyen Nghi , Li Ronald H. L.
Published: June 2024

Introduction

Cats with cardiomyopathy face an increased risk of arterial thromboembolism (ATE). Although clopidogrel is frequently utilized to mitigate this risk, feline responses to this therapy exhibit variability. This study evaluated 2 viscoelastic devices, thromboelastography (TEG) and Viscoelastic Coagulation Monitor (VCM), for monitoring clopidogrel in cats in comparison to light transmission aggregometry (LTA).

Methods

Twenty-eight healthy cats received clopidogrel for 7 days. Blood was collected at baseline and after treatment for analysis by TEG, VCM, and LTA.

Results

On LTA, maximum amplitude, slope, and area under the curve (AUC) significantly decreased after treatment (p < 0.0001). On VCM, maximum clot firmness (MCF) significantly increased after treatment (p = 0.002). On TEG, R-time significantly prolonged (p = 0.024), while K and alpha angle significantly changed (p = 0.0002 and p = 0.0014, respectively). There was a moderate negative correlation between TEG R-time and LTA AUC (r = −0.39, p = 0.042). Eight cats were identified as non-responders to clopidogrel. Of the 8 non-responders, 6 (75%) had shortened R time after treatment. VCM appeared to be less discriminatory in identifying non-responders.

Discussion

LTA remained the gold standard of monitoring clopidogrel treatment in cats. Unexpected changes on VCM and TEG were likely related to high interindividual and assay variability and increased sensitivity of feline platelets. R-time on TEG may have potential utility for point-of-care monitoring of clopidogrel response in cats.
Two Decades of Air Pollution Health Risk Assessment: Insights From the Use of WHO’s AirQ and AirQ+ Tools
Authors: Amini Heresh , Yousefian Fatemeh , Faridi Sasan , Andersen Zorana J. , Calas Ellénore , Castro Alberto , Cervantes-Martínez Karla , Cole-Hunter Thomas , Corso Magali , Dragic Natasa , Evangelopoulos Dimitris , Gapp Christian , Hassanvand Mohammad Sadegh , Kim Ingu , Le Tertre Alain , Medina Sylvia , Miller Brian , Montero Stephanie , Requia Weeberb J. , Riojas-Rodriguez Horacio , Rojas-Rueda David , Samoli Evangelia , Texcalac-Sangrador Jose Luis , Yitshak-Sade Maayan , Schwartz Joel , Kuenzli Nino , Spadaro Joseph V. , Krzyzanowski Michal , Mudu Pierpaolo
Published: June 2024

Objectives

We evaluated studies that used the World Health Organization’s (WHO) AirQ and AirQ+ tools for air pollution (AP) health risk assessment (HRA) and provided best practice suggestions for future assessments.

Methods

We performed a comprehensive review of studies using WHO’s AirQ and AirQ+ tools, searching several databases for relevant articles, reports, and theses from inception to Dec 31, 2022.

Results

We identified 286 studies that met our criteria. The studies were conducted in 69 countries, with most (57%) in Iran, followed by Italy and India (∼8% each). We found that many studies inadequately report air pollution exposure data, its quality, and validity. The decisions concerning the analysed population size, health outcomes of interest, baseline incidence, concentration-response functions, relative risk values, and counterfactual values are often not justified, sufficiently. Many studies lack an uncertainty assessment.

Conclusion

Our review found a number of common shortcomings in the published assessments. We suggest better practices and urge future studies to focus on the quality of input data, its reporting, and associated uncertainties.
Advancing neoadjuvant therapies in resectable non-small cell lung cancer: implications for novel treatment strategies and biomarker discovery
Authors: Jeon Hyein , Gor Rajvi , D’Aiello Angelica , Stiles Brendon , Illei Peter B. , Halmos Balazs
Published: June 2024

The delivery of neoadjuvant and perioperative therapies for non-small cell lung cancer has been radically altered by significant advances and by the incorporation of targeted therapies as well as immune checkpoint inhibitors alone or alongside conventional chemotherapy. This evolution has been particularly notable in the incorporation of immunotherapy and targeted therapy into the treatment of resectable NSCLC, where recent FDA approvals of drugs such as nivolumab and pembrolizumab, in combination with platinum doublet chemotherapy, have led to considerable improvements in pathological complete response rates and the potential for enhanced long-term survival outcomes. This review emphasizes the growing importance of biomarkers in optimizing treatment selection and explores the impact of emerging studies that challenge existing treatment paradigms and investigate novel therapeutic combinations poised to redefine standard of care practices. Furthermore, the discussion extends to the unmet needs within perioperative treatment assessment and prognostication, highlighting the prospective value of biomarkers in evaluating treatment responses and prognosis.
Bridges Between Soil Restoration, Land Management and Community Involvement in the Great Green Wall of Mauritania: A Preliminary Study
Authors: Vieitez-García Manuel , Roca Núria
Published: June 2024

In the Sahel, land ownership is significantly influenced by the complexity of hierarchical, ethnic, and tribal aspects as well as communal, religious, and state rights. This complicates the development of large-scale ecological projects. This study investigates the positive and negative experiences that have changed the method and attitude of agencies in Mauritania to providing a holistic and ecosystemic approach to conservation and restoration. The physical environment and society’s perception of applied restoration measures are of great importance for reducing environmental degradation and promoting future actions. Interviews with stakeholders helped understand the social reality and impact of restoration and management measures taken on the communities. The results of this study revealed that measures such as fencing plots, preventing the passage of livestock, and stabilizing sand dunes noticeably improved the vegetative cover of the soil in the Sahel. This improvement in vegetation cover has had direct effects on the improvement of soil quality indicators such as organic carbon content, pH, soil structure, color, and texture. Different stakeholders have shown considerable involvement in projects, positively valuing their implementation and observing improvements in their daily lives.
Fluid–Structure Interactions between Oblique Shock Trains and Thin-Walled Structures in Isolators
Authors: Meng Xianzong , Zhao Ruoshuai , Wang Qiaochu , Zhang Zebin , Wang Junlei
Published: June 2024

Understanding aeroelastic issues related to isolators is pivotal for the structural design and flow control of scramjets. However, research on fluid–structure interactions (FSIs) between thin-walled structures and the isolator flow remains limited. This study delves into the FSIs between thin-walled panels and the isolator flow, as characterized by an oblique shock train, by quantitatively analyzing 11 flow parameters assessing the structural response, separation zones, shock structures, flow symmetry, and performance. The results reveal that an FSI triggers panel flutter under oblique shock train conditions, with the panel shapes exhibiting a combination of first- and second-mode responses, peaking at 0.75 of the panel length. Compared to rigid wall conditions, isolators with a flexible panel at the bottom wall experience downstream movement of the separation zones and shock structures, reduced flow symmetry, and minor changes in performance. Transient fluctuations occur due to the panel flutter. Two flexible panels at the top and bottom walls have a comparatively lesser influence on the averaged parameters but exhibit more violent transient fluctuations. Furthermore, the FSI effects under oblique shock train conditions are contrasted with those under normal shock train conditions. The flutter response under normal shock train conditions is more pronounced, with a larger amplitude and higher frequency, driven by the heightened participation of the first-mode response. The effects of FSIs under normal shock train conditions on the averaged parameters are the opposite (with a larger influence) to those under oblique shock train conditions, with significantly more drastic transient fluctuations. Overall, this study sheds light on the complex and substantial influence of FSIs on the isolator flow, emphasizing the necessity of considering FSIs in future isolator design and development endeavors.
Evaluation of the Use of Vacuum-Dehydrated Minced Meat in Beef Patty Production
Authors: Başlar Mehmet , Yalınkılıç Barış , Erol Kübra Feyza , İrkilmez Mustafa Ü.
Published: June 2024

This study aimed to determine the usage potential of vacuum-dehydrated ground beef in beef patty production. First, the fresh ground beef was dehydrated in vacuum dryers at 25, 35, and 45 °C for dehydration kinetics and color change. Then, the vacuum-dehydrated ground beef was rehydrated, and three different beef patties were separately produced using fresh ground beef, the rehydrated ground beef, and a mixture of the two (1:1). According to the results, the dehydration significantly decreased the L*, a*, and b* values of ground beef; however, after rehydration, the L* and b* values were not significantly different from the control values. The cooking loss for beef patties produced with rehydrated ground beef was higher than the control. However, there was no significant difference in the sensory of the beef patties among the treatments. In conclusion, there is potential for using vacuum-dehydrated ground beef in beef patty production.
Assessing the Effectiveness of Vermi-Liquids as a Sustainable Alternative to Inorganic Nutrient Solutions in Hydroponic Agriculture: A Study on Diplotaxis muralis
Authors: Rehman Sami ur , Aprile Alessio , De Castro Federica , Negro Carmine , Migoni Danilo , Benedetti Michele , Sabella Erika , Fanizzi Francesco Paolo
Published: June 2024

Organic products are gaining popularity due to their positive impact on human health and the environment. While hydroponics is commonly used in vegetable production, it relies on mineral fertilizers derived from limited and non-renewable resources. As a result, farmers are actively seeking sustainable farming solutions. This study comprehensively evaluated the effectiveness of vermi-liquids (organic nutrient solutions) as a replacement for conventional inorganic nutrient solutions in promoting growth and nutrient acquisition in Diplotaxis muralis plants in a controlled environment. The results showed that plant biomass and SPAD values of D. muralis grown in Hoagland solution and enhanced vermitea (vermitea having relatively low pH and high EC) were higher compared to standard vermitea (high pH and low EC). The findings also revealed improved nutrient assimilation of phosphorus, potassium, calcium, iron, manganese, copper, and zinc in the enhanced vermitea plants. The heavy metal contents in D. muralis leaves were evaluated, too, and they were found to fall significantly below the safe threshold, rendering them safe for human consumption. However, the standard vermitea, with its high pH and low EC, performed poorly as a hydroponic solution. This research suggests that enhanced vermitea can completely replace chemical nutrient solutions in hydroponic agriculture. This substitution could lead to reduced production costs and improved product quality.
Customer Sentiments in Product Reviews: A Comparative Study with GooglePaLM
Authors: Shobayo Olamilekan , Sasikumar Swethika , Makkar Sandhya , Okoyeigbo Obinna
Published: June 2024

In this work, we evaluated the efficacy of Google’s Pathways Language Model (GooglePaLM) in analyzing sentiments expressed in product reviews. Although conventional Natural Language Processing (NLP) techniques such as the rule-based Valence Aware Dictionary for Sentiment Reasoning (VADER) and the long sequence Bidirectional Encoder Representations from Transformers (BERT) model are effective, they frequently encounter difficulties when dealing with intricate linguistic features like sarcasm and contextual nuances commonly found in customer feedback. We performed a sentiment analysis on Amazon’s fashion review datasets using the VADER, BERT, and GooglePaLM models, respectively, and compared the results based on evaluation metrics such as precision, recall, accuracy correct positive prediction, and correct negative prediction. We used the default values of the VADER and BERT models and slightly finetuned GooglePaLM with a Temperature of 0.0 and an N-value of 1. We observed that GooglePaLM performed better with correct positive and negative prediction values of 0.91 and 0.93, respectively, followed by BERT and VADER. We concluded that large language models surpass traditional rule-based systems for natural language processing tasks.
Preliminary Report on Diet Estimation of Taruka (Hippocamelus antisensis d’Orbigny, 1834) in an Agricultural Area of the Andean Foothills of the Tarapacá Region, Chile
Authors: Castellaro Giorgio Luis , Orellana Carla Loreto , Escanilla Juan Pablo , Fuentes-Allende Nicolás , González Benito A.
Published: June 2024

The success of conservation programs for the taruka (Hippocamelus antisensis d’Orbigny), an endemic and endangered deer, depends on many factors, highlighting anthropogenic and ecological effects. Among the latter, how this herbivore interacts with forage resources is important. The objective of the study was to describe the main attributes of the diet of this deer in rangelands adjacent to agricultural areas of the foothills of the Tarapacá Region, Chile. The botanical composition of the diet (BCD) was determined by microhistology of feces and fecal nitrogen (NF, %) was measured in two contrasting seasons (rainy summer and dry winter). From the BCD and FN, their relative diversity (J) and crude protein percentage were estimated. In the BCD, Medicago sativa dominated (27.6 ± 8.2% vs. 53.9 ± 9.2%, in rainy summer and dry end winter, respectively), followed by herbaceous dicots (46.2 ± 9.4% vs. 19.4 ± 8.7%) and shrubby species (21.5 ± 7.8% vs. 23.4 ± 7.0%), from rangelands. The contribution of grasses and graminoid species was low, not exceeding 3% and 0.4% of the diet, respectively, with no differences between seasons of the year. Intake of horticultural crop species was marginal (1.3 ± 1.3%), being detected only in the wet season. Diet relative diversity was higher during the wet period (0.75 ± 0.07) compared to the dry period (0.58 ± 0.06), since in the first period it was possible to find a greater number of palatable species. There were no significant differences in the FN attributed to the time of the year (average of 1.8 ± 0.19%), which indicates that the diet of this deer would be stable in terms of its protein quality. These FN levels estimate sufficient dietary protein content to satisfy maintenance and early pregnancy, but these could be limiting during late gestation and lactation.
FIQ: A Fastener Inspection and Quantization Method Based on Mask FRCN
Authors: Shang Zhanhao , Li Liming , Zheng Shubin , Mao Yizhou , Shi Renjie
Published: June 2024

Rail-fastening components are essential for ensuring the safety of urban rail systems by securing rails to sleepers. Traditional inspection methods rely heavily on manual labor and are inefficient. This paper introduces a novel approach to address these inefficiencies and the challenges faced by computer vision-based inspections, such as missed detections due to imbalanced samples and limitations in conventional image segmentation techniques. Our approach transitions the industry’s focus from qualitative to a more precise quantitative analysis of rail-fastening components. We propose Mask-FRCN, an advanced image segmentation network that incorporates three key technological enhancements: the fully refined convolutional network module (FRCN),which refines the segmentation boundaries for SFC-type fasteners; the Channel-WiseKnowledge Distillation (CWD) algorithm, which boosts the model’s inference efficiency; and the FCRM methodology, which enhances the extraction capabilities for features specific to SFC-type fasteners. Furthermore, we introduce a fastener system inspection and quantization method based on the Mask FRCN method (FIQ), a novel technique for quantifying the condition of components by using image features, template matching with random forests, and a clustering calculation method derived from segmentation results. Experimental results validate that our method significantly surpasses existing techniques in accuracy, thereby offering a more efficient solution for inspecting rail-fastening components. The enhanced Mask-FRCN achieves a segmentation accuracy of 96.01% and a reduced network size of 36.1 M. Additionally, the FIQ method improves fault detection accuracy for SFC-type fasteners to 95.13%, demonstrating the efficacy and efficiency of our innovative approach.
Sedimentary Evolution Laws and Main Controlling Factors of the Nenjiang Formation in the Songnan Da’anbei Area, China
Authors: Yuan Lei , Hu Mingyi , Deng Qingjie
Published: June 2024

Shallow-water deltas serve as a critical area for the exploration and development of terrestrial lacustrine oil and gas reservoirs. Current research on oil and gas exploration and development in China’s terrestrial lacustrine basins primarily focuses on their delta front facies zones. Despite extensive discussions on the sedimentary characteristics of shallow-water deltas by predecessors, there is a lack of comprehensive analysis on the combined effects of dynamic factors such as climate change, lake level fluctuations, and sediment supply. This paper, through a detailed examination of 12 core samples and integrating data from 493 exploratory, appraisal, and development wells in the study area, establishes a stratigraphic correlation framework using well–seismic integration techniques. It identifies two main sedimentary facies types in the southern Da’anbei area of the Songliao Basin: shallow-water deltas and lake facies, which can be further subdivided into four sub-facies and nine microfacies. Two depositional models for the shallow-water deltas of the Southern Songliao Nenjiang Formation are established: a deeper water background with channel-river mouth bar sequences forming the delta front framework and a shallower water background with channel-sheet sand sequences forming the delta front framework. This paper also discusses the controlling effects of paleoclimate, sediment supply, and lake level changes on sedimentary evolution, providing a scientific basis for the exploration of lithologic oil and gas reservoirs in the Nenjiang Formation of the study area and the deployment of horizontal wells.
Experiment-Based Determination of Optimal Parameters in Constant Temperature–Constant Voltage Charging Technique for Lithium-Ion Batteries Using Taguchi Method
Authors: Cheng Yu-Shan , Lin Su-Fen , Ho Kun-Che
Published: June 2024

Charging methods significantly affect the performance and lifespan of lithium-ion batteries. Investigating charging techniques is crucial for optimizing the charging time, charging efficiency, and cycle life of the battery cells. This study introduces a real-time charging monitoring platform based on LabVIEW, enabling observation of battery parameters such as voltage, current, and temperature. The proposed system allows the precise control of charging parameters via a user-friendly interface. Utilizing a programmable DC power supply, it delivers specific charging waveforms, while data acquisition instruments record temperature changes. Key performance metrics, including charging time, efficiency, and temperature rise, are analyzed. Moreover, this paper conducts in-depth research on the constant temperature–constant voltage (CT-CV) charging technique and applies the Taguchi method to identify key parameter configurations that achieve the objectives of the shortest charging time, highest charging efficiency, and lowest average temperature rise. A comprehensive evaluation compares the optimized CT-CV method with conventional constant current–constant voltage (CC-CV) charging. The results demonstrate a 10.7% reduction in charging time compared to the 1C CC-CV method, indicating the efficacy of CT-CV in shortening charging duration while managing temperature rise.
Adenylyl Cyclase in Ocular Health and Disease: A Comprehensive Review
Authors: Thompson Polly , Vilkelyte Virginija , Woronkowicz Malgorzata , Tavakoli Mitra , Skopinski Piotr , Roberts Harry
Published: June 2024

Adenylyl cyclases (ACs) are a group of enzymes that convert adenosine-5′-triphosphate (ATP) to cyclic adenosine 3′,5′ monophosphate (cAMP), a vital and ubiquitous signalling molecule in cellular responses to hormones and neurotransmitters. There are nine transmembrane (tmAC) forms, which have been widely studied; however, the tenth, soluble AC (sAC) is less extensively characterised. The eye is one of the most metabolically active sites in the body, where sAC has been found in abundance, making it a target for novel therapeutics and biomarking. In the cornea, AC plays a role in endothelial cell function, which is vital in maintaining stromal dehydration, and therefore, clarity. In the retina, AC has been implicated in axon cell growth and survival. As these cells are irreversibly damaged in glaucoma and injury, this molecule may provide focus for future therapies. Another potential area for glaucoma management is the source of aqueous humour production, the ciliary body, where AC has also been identified. Furthering the understanding of lacrimal gland function is vital in managing dry eye disease, a common and debilitating condition. sAC has been linked to tear production and could serve as a therapeutic target. Overall, ACs are an exciting area of study in ocular health, offering multiple avenues for future medical therapies and diagnostics. This review paper explores the diverse roles of ACs in the eye and their potential as targets for innovative treatments.