bluuebunny/crossref_metadata_2025 huggingface dataset:
Augmented Reality in Physical Therapy: Systematic Review and Meta-analysis (Preprint)
Authors: Vinolo Gil Maria Jesus , Gonzalez-Medina Gloria , Lucena-Anton David , Perez-Cabezas Veronica , Ruiz-Molinero María Del Carmen , Martín-Valero Rocío
Published: June 2021

BACKGROUND

Augmented reality (AR) is a rapidly expanding technology; it comprises the generation of new images from digital information in the real physical environment of a person, which simulates an environment where the artificial and real are mixed. The use of AR in physiotherapy has shown benefits in certain areas of patient health. However, these benefits have not been studied as a whole.

OBJECTIVE

This study aims to ascertain the current scientific evidence on AR therapy as a complement to physiotherapy and to determine the areas in which it has been used the most and which variables and methods have been most effective.

METHODS

A systematic review registered in PROSPERO (International Prospective Register of Systematic Reviews) was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) recommendations. The search was conducted from July to August 2021 in the PubMed, PEDro, Web of Science, Scopus, and Cochrane Library scientific databases using the keywords augmented reality, physiotherapy, physical therapy, exercise therapy, rehabilitation, physical medicine, fitness, and occupational therapy. The methodological quality was evaluated using the PEDro scale and the Scottish Intercollegiate Guidelines Network scale to determine the degree of recommendation. The Cochrane Collaboration tool was used to evaluate the risk of bias.

RESULTS

In total, 11 articles were included in the systematic review. Of the 11 articles, 4 (36%) contributed information to the meta-analysis. Overall, 64% (7/11) obtained a good level of evidence, and most had a B degree of recommendation of evidence. A total of 308 participants were analyzed. Favorable results were found for the Berg Balance Scale (standardized mean change 0.473, 95% CI −0.0877 to 1.0338; z=1.65; P=.10) and the Timed Up and Go test (standardized mean change −1.211, 95% CI −3.2005 to 0.7768; z=−1.194; P=.23).

CONCLUSIONS

AR, in combination with conventional therapy, has been used for the treatment of balance and fall prevention in geriatrics, lower and upper limb functionality in stroke, pain in phantom pain syndrome, and turning in place in patients with Parkinson disease with freezing of gait. AR is effective for the improvement of balance; however, given the small size of the samples and the high heterogeneity of the studies, the results were not conclusive. Future studies using larger sample sizes and with greater homogeneity in terms of the devices used and the frequency and intensity of the interventions are needed.

CLINICALTRIAL

PROSPERO International Prospective Register of Systematic Reviews CRD42020180766; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=180766
Correction: Building Health Services in a Rapidly Changing Landscape: Lessons in Adaptive Leadership and Pivots in a COVID-19 Remote Monitoring Program (Preprint)
Authors: Laur Celia Violet , Agarwal Payal , Mukerji Geetha , Goulbourne Elaine , Baranek Hayley , Pus Laura , Bhatia R Sacha , Martin Danielle , Bhattacharyya Onil
Published: June 2021

UNSTRUCTURED

REMOVE
Surface Complexation of Chromium(VI) on Iron(III) Hydroxide: Mechanisms and Stability Constants of Surfaces Complexes
Authors: Hmamou Mhamed , Maarouf Fatima Ezzahra , Ammary Bouchaib , Bellaouchou Abdelkebir
Published: June 2021

The adsorption of chromate ions H2-yA (y = 1, 2, and A = CrO42–) on iron(III) hydroxide was conducted as a function of adsorbent mass, solution pH, and hydration time. The surface complexation technique, based on the examination of the chromate distribution between the solid and liquid phases, was adopted to predict the adsorption mechanism. To specify stoichiometry of the chromate surface complexes, the proton (n > 0), and hydroxyl (n < 0) ion-exchange was evaluated at a pH range of 2–12. The obtained “n” values are ranging between -1 and 1. As a result, the sorption process involved specific chemical interaction with surface sites, resulting in 1H+ and 1OH– release of the adsorbate molecule. The surface species identified were ; ; ; ; ; ; ;  and . The logarithmic values of their complexing constants were: log K00 = 1.81 ± 0.04; log K11 = -3.53 ± 0.07; log K21 = -1.03 ± 0.23, log K1-1 = 7.15 ± 0.14 and log K2-1 = 9.62 ± 0.53. The results showed that the chromate adsorption on Fe(III) hydroxide was of electrostatic and chemical nature at pH lower than 5.5, and only of chemical nature at pH superior to 5.5. Taking into account these considerations, Fe(III) hydroxide could be considered an excellent sorbent for the removal of Cr(VI) from wastewater solutions.
Anticancer Activities of Chemical Constituents from Leaves and Twigs of Mitrephora winitii
Authors: Sukdee Sukee , Meepowpan Puttinan , Nantasaen Narong , Jungsuttiwong Siriporn , Hadsadee Sarinya , Pompimon Wilart
Published: June 2021

The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and extracted with n-hexane, ethyl acetate and methanol, respectively. Chromatographic separations of these extracts led to the isolation of three known compounds and one new compound (compound 2). The chemical structures of these were identified using spectroscopic investigation of 1D- and 2D-NMR and the resulting data confirmed these as stigmasterol (1), (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-4-(hydroxymethyl)tetrahydrofuran-3-yl)methanol (2), diayangambin (3), and methyl-L-inositol (4). The chemical constituents were reported the first time in M. winitii. Compound 2 showed anti-cancer cell lines with ED50 13.07 µg/mL against KB cells and then was tested for cytotoxicity against MCF-7 cells with ED50 11.77 µg/mL.
The capability of early detection of eye diseases in the community by primary health facility worker
Authors: Widyandana Doni , Prayogo Muhammad Eko , Suhardjo Suhardjo
Published: June 2021

Cataract is one of the biggest causes of blindness in the world. As many as 2.4 million people suffered from cataracts in Indonesia in 2013. Therefore, early detection needs to be done to prevent further complications. However, health workers' limited ability in primary health care facilities has resulted in high cataract diagnosis rates. The purpose of this study was to determine the ability of early detection of eye diseases, especially cataracts by primary health care workers. This study was conducted using a quantitative descriptive method analyzing 158 medical records as a result of early detection of primary health care facilities in Sleman Regency, which were sent to the ophthalmologist team of the Department of Eye Health FKKMK UGM to be re-examined. The re-examination results by a team of ophthalmologists received 141 medical records that fulfilled the inclusion criteria, consisting of 61 patients confirmed by cataract diagnosis (43.3%) and 80 patients with a diagnosis of not cataract (56.7%). According to the study, primary health care workers' ability towards early detection of cataracts in Sleman Regency needed to be enhanced (4.3%).
Role of community figure in Healthy Indonesia Program with family approach (PIS-PK) in Banjarnegara District, Central Java
Authors: Mujiati Mujiati , Sulistiowati Eva , Nurhasanah Siti
Published: June 2021

The involvement of community figure is one form of participation in health development, including in the Healthy Indonesia Program with Family Approach (PIS-PK). The purpose of this study was to determine the role of community figure in PIS-PK. The type of study was a qualitative study in one kelurahan which was included in the working area of Community Health Care (CHC) Banjarnegara 1 in Banjarnegara District, Central Java, which was chosen purposively. Data collection was done by in-depth interview. The key informants were community figure, namely from the kelurahan (kelurahan head and its staff) and community members who were considered community figure in the village. Data triangulation was done by conducting in-depth interview with the head and staff of community health centre and the community. Data that has been obtained was analyzed thematically. The results of the study showed that community figure played an important role in the implementation of PIS-PK as sources of information about PIS-PK, helping field organizing, helping prepare complete families documents, assisting CHC staff and surveyor in home visits and helping solve problems that arise, and generally playing a role in the smooth implementation of PIS-PK. Social support from the local government and communities can be a motivation to continue to play a role in supporting the success of PIS-PK.
Clinical findings in determining referral criteria for coronavirus disease (COVID-19) patients at a makeshift isolation center of Bekasi, West Java
Authors: Hayon Stefi Geovani Valentin , Priscilia Florentina , - Hariri
Published: June 2021

COVID-19 has become a pandemic concern with the clinical manifestations ranging for asymptomatic to severe organ failure. Early contact tracing and isolation are important keys to slow the infection spread within communities. Clinical triage and early recognition of warning signs on admission are needed to classify patients based on clinical severity. Due to the limited capacity of hospital settings for COVID-19 patients, a makeshift isolation center is needed for all confirmed and suspected cases with mild or no symptoms who will be provided with basic medical care, frequent monitoring, and rapid referrals. During observations, the physician needs to raise early alertness of the patient who is at risk to develop a worse outcome. This study reports five cases of patients who came with mild or no symptoms at initial presentation and developed into worsening disease progression after several days of observation. These patients developed shortness of breath, fatigue, abdominal disturbances, and chest pain. These findings were supported by the physical examinations that showed a decrease in blood oxygen saturation. Similarly, with the Centers for Disease Control and Prevention (CDC) criteria for the early warning signs, these patients were referred to the hospital-based isolation setting that could provide more advanced and optimal management. This study describes clinical manifestations of COVID-19 patients to decide the ideal time for referral.
Early detection and primary prevention system in COVID-19 transmission to staff and residents in the department of obstetrics and gynecology
Authors: Rahman Muhammad Nurhadi , Nurdiati Detty Siti , Pangastuti Nuring , Widyasari Anis , Maliki Fauzan Achmad , Andari Sarah Ayu , Hashifah Khairina
Published: June 2021

COVID-19 is currently a global pandemic because of its fast transmission in humans. The disease can be symptomatic or asymptomatic. Patients with the disease can transmit the infection to the medical team who are exposed without proper protection. Prevention of transmission is our main focus of attention as well as early recognition of exposed medical teams among obstetrics and gynecology residents and consultants in our hospital. This article aimed to describe the COVID-19 early detection and primary prevention system among staff and residents in the Obstetrics and Gynecology (OBSGYN) Department, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada and Dr. Sardjito General Hospital from April to June 2020. The data were acquired from the reports of the COVID-19 taskforce from the OBSGYN Department. In order to prevent the transmission of COVID-19 infection, actions taken by the OBSGYN Department are as follows: a) arrangement of staff and residents watch schedules, b) usage of PPE (Personal Protective Equipment) according to protocol, c) contact tracing, and d) early detection. Resident watch schedule arrangement is done by withdrawing residents from affiliated hospitals so that the division of daily duty schedules at Dr. Sardjito General Hospital is divided into 2 shifts of 12 hours each. The PPE usage policy is adjusted according to the risk of COVID-19 exposure in different environments and in accordance with established standards. A total of 65 out of 74 residents (88%) had been exposed to suspected COVID-19 cases, and among the exposed residents, 12 residents (18%) were self-isolated because of the occurrence of symptoms, exposure to patients with positive COVID-19 rapid antibody test, or exposure to patients with positive COVID-19 Polymerase Chain Reaction (PCR) test. The department also conducted early detection of COVID-19 infection among all staff members and residents. As many as 13 out of 27 staff (48%) underwent COVID-19 rapid antibody test with 100% negative results, 66 of the 74 residents (89%) also underwent COVID-19 rapid antibody test with 100% negative results. In conclusion, the OBSGYN Department has implemented several measures to prevent transmission of COVID-19 among its staff and residents with adequate satisfactory results.
Responsabilidad social empresarial y el fortalecimiento del talento humano en las organizaciones
Authors: Canizales Muñoz Luis D.
Published: June 2021

Una organización que se considere exitosa, necesariamente debe tener implementada una estrategia de responsabilidad social. En este sentido, la presente investigación busca analizar cuál es el impacto que tiene la responsabilidad social empresarial con el fortalecimiento del talento humano en las organizaciones. Para lograr este propósito se recurre a la realización de una investigación con un enfoque cualitativo y un alcance descriptivo, mediante una revisión documental de bases de datos de revistas indexadas, repositorios institucionales y sitios de búsqueda especializada. Se logró identificar que la responsabilidad social empresarial tiende a ser entendida como aquellas actividades filantrópicas que las organizaciones realizan en los sectores en donde operan, cuando en realidad el concepto es mucho más profundo, y parte, como primera medida, de fortalecerse internamente invirtiendo en la mejora y el crecimiento personal y profesional de sus colaboradores, lo cual le permitirá permanecer en el mercado obteniendo los mejores resultados. En Colombia se tiene aún una percepción reduccionista de esta importante relación entre la responsabilidad social empresarial y el fortalecimiento del talento humano, por lo cual los líderes empresariales deben empezar a establecer la urgencia de la adopción de esta sinergia, de lo contrario, y ante la globalización de los mercados, las organizaciones colombianas no serán lo suficientemente competitivas ni sobresalientes en el escenario internacional.
Estudio sobre el uso de Tecnologías de la Información y la Comunicación para mejorar la calidad educativa
Authors: Marín Reyes Sharon A. , Ortega-Tudela Juana M. , Peña Hita Mª Ángeles
Published: June 2021

Este artículo presenta los hallazgos del desarrollo del proceso de investigación relacionado con el uso de estrategias pedagógicas mediadas por las Tecnologías de la Información y la Comunicación (TIC) en los procesos de enseñanza y aprendizaje de las instituciones educativas de Urabá, Colombia. Se define un método de investigación con enfoque cualitativo mixto (CUAL+cuan) y alcance descriptivo-relacional, para lo que se utilizan instrumentos de revisión documental, cuestionarios, pruebas, entrevistas y grupos focales; además, se desarrolla una fase de diagnóstico inicial y otra final, para la medición comparativa, así como una serie de actividades pedagógicas que facilitan la apropiación de los docentes en el uso de las TIC en sus prácticas de aula. Entre los principales hallazgos se destaca que el uso de las TIC en los procesos educativos permite el fortalecimiento de las competencias digitales y el mejoramiento de los resultados de desempeño académico; sin embargo, la integración TIC-educación debe estar soportada en una estrategia pedagógica sólida, que se complemente con el cumplimiento de otras exigencias como, la dotación de infraestructura tecnológica en las escuelas, la formación técnica y pedagógica de los docentes y el mejoramiento de las políticas gubernamentales.
ClusterMix K-Prototypes Algorithm to Capture Variable Characteristics of Patient Mortality With Heart Failure
Authors: Novidianto Raditya , Wibowo Hardianto , Chandranegara Didih Rizki
Published: June 2021

Cardiovascular Disease (CVD) is one of the leading causes of many death worldwide, leading to heart failure incidence. The World Health Organization (WHO) says the number of people dying from cardiovascular disease from heart failure each year has an average of 17,9 million deaths each year, about 31 percent of the total deaths globally. Identify the mortality factors of heart failure patients that need to be formed, which reduces death due to heart failure. One of them is by using variable mortality due to heart failure by applying the k-prototypes algorithm. The clustering result is formed 2 clusters that are considered optimal based on the highest silhouette coefficient value of 0,5777. The results of the study were carried out as segmentation of patients with variable mortality of heart failure patients, which showed that cluster 1 is a cluster of patients who have a low risk of the chance of mortality due to heart failure and cluster 2 is a cluster of patients with a high risk of mortality due to heart failure. The segmentation is based on the average value of each variable of heart failure mortality factor in each cluster compared to normal conditions in serum creatine variables, ejection fraction,  age,  serum sodium, blood pressure, anemia,  creatinine phosphokinase,  platelets, smoking, gender, and diabetes.
Could digital technologies help improving management accounting in pandemic times?
Authors: Ulrich Patrick , Kratt Mona
Published: June 2021

In the field of management accounting, there is an enormous backlog of demand from a scientific and practical point of view around the topic of implementing new technologies to increase efficiency and effectiveness. This applies not only, but especially to small and medium-sized enterprises (SMEs), which have fewer human and financial resources than large companies. This research-in-progress article discusses potentials and implementation obstacles of new technologies in management accounting on the basis of an empirical survey among German SMEs from the year 2020
A corporate governance perspective on IT governance
Authors: Correia Anacleto , Água Pedro B.
Published: June 2021

IT governance encompasses the processes for aligning business and IT efforts to accomplish optimal value from the business by means of the implementation of effective IT control and accountability, performance and risk management. Despite IT governance awareness in recent years, there is a lack of a holistic view of the organization’s IT governance that could help board directors to have an overall map of the current situation and anticipate the further steps needed to raise its level of maturity. This text proposes a classification scheme for IT governance according to two orthogonal dimensions: the stakeholders’ perspective (from corporate board to end-users) as well as the primitives that are an object of IT governance. The proposed scheme, evolved from enterprise architecture research, is in line with other solutions aimed at aligning the business and IT within organisations
Wisdom for IT governance: A perspective of the philosophy of the art of war
Authors: Chen Le , Pavone Pietro
Published: June 2021

In a cyber-war age, it is not an exaggeration to compare the importance of IT governance systems of organizations as national defense systems that protect national security. The high-speed development of information technology has triggered a surge in its applications and related investments, which has greatly promoted the way of working within organizations. As a disruptive model, information technology has penetrated all aspects of the organizations, and even played some important alternative roles. Even in the era of peace, international competition has never stopped but has intensified, having formed a competitive trend in the development of global information technology. Facing the current complex business environment, an organization needs to have well-addressed strategies. Consequently, IT governance within the organizations must be conducted and better strengthened. As it is a part of organizational governance, it is necessary to systematically and comprehensively ensure that information technology-related investments have organization value from a high level of strategic assessment, as well as reduce information technology-related risks, to guarantee organizations the whole performance and competitive advantages. This study aims to analyze IT governance from the perspective of the philosophical thinking of The Art of War.
BETYDNINGEN AV KLANGLIGE OG VISUELLE ROM I INNSPILT MUSIKK
Authors: Nesvold Mari
Published: June 2021

- Et kunstnerisk eksperiment
The Place of Design in "Design Thinking"
Authors: Bente Irminger
Published: June 2021

Design in the place of Design Thinking
Økt interesse for kreativitet åpner for nye designerroller- men skaper også behov for rolleavklaringer
Authors: Bente Irminger
Published: June 2021

De siste årene har den tverrfaglige innovasjonsprosessen «Design Thinking» gjort at en større del av næringsliv og offentlig sektor har begynt å interessere seg for designfaget. Mens faget tradisjonelt har vært knyttet til utforming av produkter og forming av omgivelser, kan design i dag handle om metoder og prosesser, noe som gjør faget relevant for flere samfunnsområder. I artikkelen presenterer vi noen hovedkjennetegn ved designfaget i dag, og drøfter også hvilke forventninger og ulike designerroller nyutdannede designere møter og kan komme til å møte i fremtiden.
The protonation state of Glu202 in acetylcholinesterase
Authors: Wang Jiye , Lai Suitian , Kong Yichao , Yao Weixuan , Chen Xiabin , Liu Junjun
Published: June 2021

Acetylcholinesterase (AChE) is the crucial enzyme in the central nervous
system. It is the target of various organophosphorus nerve agents and
pesticides, and the inhibition of AChE is a therapeutic strategy for the
treatment of various neurological-related diseases. The Glu202 is a key
residue adjacent to the catalytic His447 and plays important role in
catalysis. Although the Glu202 has long been considered as negatively
charged in many studies, more and more evidences support a protonated
Glu202. However, Glu202 is freely accessible by solvent, and thus it
seems more reasonable for Glu202 to majorly take the deprotonated state.
In the present work, we carried out a series of molecular dynamics
simulations with the Glu202 adopting different protonation states. Our
results show that the protonated Glu202 is important in maintaining the
key hydrogen bond network that supports the catalytic triad, whereas the
deprotonated Glu202 results in the collapse of the key hydrogen bond
network which consequently destabilizes the catalytic His447. We also
notice that different protonation states of Glu202 merely alters the
binding mode of ACh. However, since the catalytic His447 is disrupted if
Glu202 is deprotonated, His447 can not facilitate the nucleophilic
attack performed by Ser203. Therefore, the catalytic efficiency of ACh
hydrolysis should be remarkably decreased if Glu202 is deprotonated. Our
findings suggest that, when designing and developing highly active AChE
inhibitors or proposing mechanistic hypotheses for AChE-catalyzed
reactions, the protonated state of Glu202 should be considered.
Time-domain signal averaging to improve microparticles detection and enumeration accuracy in a microfluidic impedance cytometer
Authors: Ashley Brandon , Hassan Umer
Published: June 2021

Microfluidic impedance cytometry is a powerful system to measure micro
and nano-sized particles and is routinely used in point-of-care settings
disease diagnostics and other biomedical applications. However, small
objects near a sensor’s detection limit are plagued with relatively
significant background noise and are difficult to identify for every
case. While many data processing techniques can be utilized to reduce
noise and improve signal quality, frequently they are still inadequate
to push sensor detection limits. Here, we report the first demonstration
of a novel signal averaging algorithm effective in noise reduction of
microfluidic impedance cytometry data, improving enumeration accuracy
and reducing detection limits. Our device uses a 22 μm tall microchannel
and gold coplanar microelectrodes that generates an electric field,
recording bipolar pulses from polystyrene microparticles flowing through
the channel. In addition to outlining a modified moving signal averaging
technique theoretically and with a model dataset, we also performed a
compendium of characterization experiments including variations in flow
rate, input voltage, and particle size. Multi-variate metrics from each
experiment are compared including signal amplitude, pulse width,
background noise, and signal-to-noise ratio (SNR). Incorporating our
technique resulted in improved SNR and counting accuracy across all
experiments conducted, and the limit of detection improved from 5 μm to
1 μm particles without modifying microchannel dimensions. Succeeding
this, we envision implementing our modified moving average technique to
develop next generation microfluidic impedance cytometry devices with an
expanded dynamic range and improved enumeration accuracy. This can be
exceedingly useful for many biomedical applications, such as infectious
disease diagnostics where devices may enumerate larger-scale immune
cells alongside sub-micron bacterium in the same sample.
Surgical management of extensive aortic root endocarditis with ventricular septal rupture: A case report
Authors: Maeba Satoru , Kawashima Dai , Saito Masahiro , Okano Ryoi , Sunada Masatoshi , Ito Takuya
Published: June 2021

A 79-year-old man was referred for severe cardiac decompensation. Chest
radiography showed severe pulmonary edema, and transesophageal
echocardiography revealed a large quantity of vegetation on all aortic
valve leaflets with severe aortic valve regurgitation, heterogeneous
cavities adjacent to the aortic annulus, and ventricular septal rupture.
We performed thorough and extensive debridement of the aortic root;
including the infected ventricular septum, reconstructed the ventricular
septum and aortic root using autologous and bovine pericardial patches;
and placed a bioprosthetic stented valve. The patient was discharged
without any complications, and without recurrence of the endocarditis in
the four years post-surgery.
A case of primary vulva epidermoid cyst
Authors: Liu Chu , Guo Xiaohui , Lan Hua , Zeng Da , Yuan Jing , Yong Jiahui , Xiao Songshu
Published: June 2021

In this report, We discuss a case of epidermoid cyst originating from
the female vulva, which was completely excised by surgery.
Pathologically confirmed as a vulva epidermoid cyst.
High bandwidth RF and microwave photonic signal processing using Kerr micro-combs
Authors: Moss David
Published: June 2021

Integrated Kerr micro-combs, a powerful source of many wavelengths for photonic RF and microwave signal processing, are particularly useful for transversal filter systems. They have many advantages including a compact footprint, high versatility, large numbers of wavelengths, and wide bandwidths. We review recent progress on photonic RF and microwave high bandwidth temporal signal processing based on Kerr micro-combs with spacings from 49-200GHz. We cover integral and fractional Hilbert transforms, differentiators as well as integrators. The potential of optical micro-combs for RF photonic applications in functionality and ability to realize integrated solutions is also discussed.
Traffic Analysis and Collision Pattern ( Vision Zero)
Authors: Kasem Alia
Published: June 2021

This analysis will primarily focus on the number of collisions before
and after NYC adopting  Vision Zero. In this analysis, the statistical
model of K-S testing will be used to compare the two periods;  before
and after the adoption of Vision Zero. The study will include a time
series of the effectiveness of Vision Zero using the data; based on the
cumulative number of accidents. The cumulative number and daily pattern
of the collisions will measure probabilities of effectiveness.
Giant Interatrial Septal Lipoma Filling with Right Atrium Causing Slight Symptoms: A Case Report
Authors: Chen Mingxiang , Li Fuping , Zhang Haitao , Qin Zhuyun
Published: June 2021

Cardiac lipoma is extremely rare. Here we presented a unique
illustrative case of interatrial septal lipoma protruding into right
atrial causing symptoms in a 54-year-old male. Echocardiogram and
computed tomography showed a well-shaped, giant and fixed occupying
located in interatrial septum and right atrium. The only manifestation
was palpitation though the mass filled almost all atrium and compressed
superior vena cava. The patient received resection of the large-sized
lipoma sizing 87mm in diameter and weighing ~1000g.
Pathological exam demonstrated mature lipocytes and substantiated the
diagnosis of lipoma. The patient did well postoperatively and symptoms
were resolved.
Seroconversion and adverse events in the first month after the administration of two doses of the inactivated SARS-CoV-2 vaccine in Turkey: Is a booster dose required?
Authors: Mete Burak , Tanir Ferdi , Demirhindi Hakan , Kara Ertan , Kibar Filiz , Cetiner Salih , Candevir-Ulu Aslihan , Dal Rabia
Published: June 2021

Aims: Limited information is available about the efficacy and adverse
events of COVID-19 vaccines introduced into public use with Emergency
Usage Licences without completing phase-3 trials. Data refer to healthy
and mostly younger people, with lacking evidence about the protectivity.
This study aimed determining seroconversion rates and levels specific to
anti-S-RBD IgG and total anti-spike/anti-nucleocapsid IgM and IgG
antibodies against SARS-CoV-2 after the administration of two doses of
the inactivated SARS-CoV-2 vaccine in Turkey, comparing three types of
antibodies. It was also aimed to assess short-term adverse events due to
the vaccine. It is intended to answer the questions about efficacy and
safety, which lack in phase trials, especially at community level. It is
also aimed to collect data, which will form the basis for assessing
whether antibodies are protective at different community settings.
Methods: The study carried out in Turkey, comprised 282 healthcare
workers who received two doses of the inactivated SARS-CoV-2 vaccine
administered in two 3µg doses, 28 days apart. In day-28 after the second
dose, anti-S-RBD IgG and total anti-spike/anti-nucleocapsid IgM and IgG
antibodies against SARS-CoV-2 were detected by in-vitro
chemiluminescence immunoassay. Results: At day 28 after the second dose,
the seroconversion rates were found to be 92.9% for total
anti-spike/anti-nucleocapsid IgG and 15.2% for IgM and 98.2% for
anti-S-RBD IgG antibodies. The immunogenicity was affected by
pre-vaccination natural COVID-19 history and age. The incidence of at
least one adverse event was found as 29.8% after the first dose and
24.1% after the second dose, with the most common events being pain at
the injection site, weakness, fatigue and headache. Conclusion: A high
rate of seroconversion was observed with no serious adverse events.
Prior natural COVID-19 history and age significantly contributed to
strong immunogenicity. A booster dose appears required for older ages
and individuals without immune response.
3D printing of self-standing and vascular supportive multi-material hydrogel structures for organ engineering
Authors: Hu Qingxi , Liu Suihong , Zhang Haiguang , Shen Zhipeng , Krishnan Sasirekha , Ramalingam Murugan
Published: June 2021

Three dimensional printable formulation of self-standing and
vascular-supportive structures using multi-materials suitable for organ
engineering is of great importance and highly challengeable, but, it
could advance the 3D printing scenario from printable shape to
functional unit of human body. In this study, the authors report a 3D
printable formulation of such self-standing and vascular-supportive
structures using an in-house formulated multi-material combination of
albumen/alginate/gelatin (A-SA-Gel)-based hydrogel. The rheological
properties and relaxation behavior of hydrogels were analyzed prior to
the printing process. The suitability of the hydrogel in 3D printing of
various customizable and self-standing structures, including a human ear
model, was examined by extrusion-based 3D printing. The structural,
mechanical, and physicochemical properties of the printed scaffolds were
studied systematically. Results supported the 3D printability of the
formulated hydrogel with self-standing structures, which are
customizable to a specific need. In vitro cell experiment showed that
the formulated hydrogel has excellent biocompatibility and vascular
supportive behavior with the extent of endothelial sprout formation when
tested with human umbilical vein endothelial cells. In conclusion, the
present study demonstrated the suitability of the extrusion-based 3D
printing technique for manufacturing complex shapes and structures using
multi-materials with high fidelity, which have great potential in organ
engineering.
Angela Carter'ın Heroes and Villains Adlı Eserinde Marianne'nin Beden Politikası
Authors: EKMEKÇİ Çelik
Published: June 2021

Beden politikası, toplumların beklentilerine göre tabii olarak düzenlenmesi beklenen kadın bedeni üzerindeki ataerkil dikte ve kaideleri benimseten bir mekanizma olarak görülmektedir. Tarih boyunca, kadın bedeni bir araç olarak görülmüş olup beden politikasının kuramsal dayanağı, kadın bedeninin ataerkil ideoloji tarafından düzenlenmesine dayalı olarak ortaya çıkmıştır. Ataerkil ideolojiye göre, kadınların bedenleri, değeri olmayan değersiz, ikincil bir zemin olarak görülmektedir. Fakat feminizm, kadınların bedenlerini edebi açıdan inceler ve kavramsallaştırır ayrıca kadınları inceleyerek çeşitli kadın kimliklerini yeniden yaratır ve alternatifler üretir. Bu bağlamda, Angela Carter’ın eserlerinde özellikle de Heroes and Villains’de kadın bedeni politikasının tarihsel ve varsayımsal açıklaması üzerine farklı bir tutum vardır. Carter’ın birçok kadın kahramanları erkek bedenlerini provoke edip onları suistimal eder böylece bu kadın karakterler, erkek bedenlerinin suistimal edilmiş ve çarpıtılmış hallerini yansıtırlar. Bu çalışma, Carter’ın kuramsal ve kritik düşüncelerine ilaveten, Carter’ın Heroes and Villains adlı eserindeki ana karakter Marianne’in ataerkil düşüncenin beden politikası üzerindeki görüşlerinin tam zıttı olan tutumunu incelemektedir. Ayrıca, ana karakterin, ataerkil kaideleri, bedenini güç elde etmede bir araç olarak kullanarak reddetmesi ve kendi beden politikasını, erkek egemen dünyada adeta hayatta kalmak adına kullanması, bu eserde incelenmektedir. Böylece, Heroes and Villains’de kadın bedeni, kadınlığın bir gücü olarak görülmekte olup ataerkilliğe karşı bir silah olarak kullanılmaktadır.
Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes
Authors: Brown Sue A. , Forlenza Gregory P. , Bode Bruce W. , Pinsker Jordan E. , Levy Carol J. , Criego Amy B. , Hansen David W. , Hirsch Irl B. , Carlson Anders L. , Bergenstal Richard M. , Sherr Jennifer L. , Mehta Sanjeev N. , Laffel Lori M. , Shah Viral N. , Bhargava Anuj , Weinstock Ruth S. , MacLeish Sarah A. , DeSalvo Daniel J. , Jones Thomas C. , Aleppo Grazia , Buckingham Bruce A. , Ly Trang T.
Published: June 2021

Objective:
Advances in diabetes technology have transformed the treatment paradigm for
type 1 diabetes, yet the burden of disease is significant. We report on a
pivotal, safety study of the first tubeless, on-body automated insulin delivery
system with customizable glycemic targets.

Research Design and Methods:
This single-arm, multicenter, prospective study enrolled 112 children
(6-13.9 years) and 129 adults (14-70 years). A two-week standard therapy phase
(usual insulin regimen) was followed by 3 months of automated insulin delivery.
Primary safety outcomes were incidence of severe hypoglycemia and diabetic
ketoacidosis. Primary effectiveness outcomes were change in HbA1c and percent time in sensor
glucose range 70-180mg/dL.

Results: 235 participants
(98% of enrolled: 111 children, 124 adults) completed the study. HbA1c was significantly reduced in
children by 0.71% (7.8mmol/mol) (mean±standard deviation: 7.67±0.95% to
6.99±0.63%, 60±10.4mmol/mol to 53±6.9mmol/mol, p<0.0001) and in
adults by 0.38% (4.2mmol/mol) (7.16±0.86% to 6.78±0.68%, 55±9.4mmol/mol to
51±7.4mmol/mol, p<0.0001). Time in range was improved from standard
therapy by 15.6±11.5% or 3.7 hours/day in children and 9.3±11.8% or 2.2
hours/day in adults (both p<0.0001). This was accomplished with a reduction
in time in hypoglycemia <70mg/dL among adults (median (interquartile range):
2.00% (0.63, 4.06) to 1.09% (0.46, 1.75), p<0.0001), while this
parameter remained the same in children. There were 3 severe hypoglycemia
events not attributable to automated insulin delivery malfunction and 1
diabetic ketoacidosis event from an infusion site failure.

Conclusions: This
tubeless automated insulin delivery system was safe, and allowed participants to significantly
improve HbA1c levels
and time in target glucose range with a very low occurrence of hypoglycemia.
Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?
Authors: Julla Jean-Baptiste , Jacquemier Pauline , Fagherazzi Guy , Vidal-trecan Tiphaine , Juddoo Vanessa , Jaziri Asma , Mersel Hanane , Venteclef Nicolas , Roussel Ronan , Massin Pascale , Couturier Aude , Gautier Jean-François , Riveline Jean-Pierre
Published: June 2021

Objective: Estimating glucose variability (GV) through within-day
coefficient of variation (%CVw) is recommended for patients with
type-1 Diabetes (T1D). High-GV (hGV) is defined as %CVw>36%.
However, continuous glucose monitoring (CGM) devices provide exclusively total-CV
(%CVT). We aimed to assess consequences of this disparity.

Research Design and Methods: We retrospectively calculated both %CVT
and %CVW of consecutive T1D patients from their CGM raw data during
14 days. Patients with hGV
with %CVT>36% and %CVw≤36% were called the
“inconsistent-GV group”.

Results: 104 patients were included. Mean %CVT and %CVw were
42.4+/-8% and 37.0+/-7.4% respectively (p<0.0001). Using %CVT, 81
patients (73.6%) were classified as hGV whereas 59 (53.6%) using %CVW (p<0.0001)
corresponding to 22 patients (21%) in the “inconsistent-GV
population”.

Conclusions: Evaluation of GV through %CV in patients with T1D is highly
dependent on the calculation method and then must be standardized.
Elección de carrera e institución de educación superior: validación de instrumento de medición mediante el modelado de ecuaciones estructurales
Authors: García Martínez Rafael , Poblano-Ojinaga Eduardo Rafael , Reyes Valenzuela Rigoberto , Cuamea Cruz Guillermo , Juárez Rodríguez Rubén
Published: June 2021

La elección de institución y carrera universitaria que realiza el egresado de la educación media superior es una variable que impacta en la deserción escolar, un indicador de calidad de las universidades. En la literatura revisada se proponen diferentes modelos que describen la relación de esta variable con un conjunto de factores, sin embargo, dichos modelos no son del tipo correlacional, por lo que no es posible establecer cuál de los factores tiene más peso o impacto ni la estructura de correspondencia entre ellos. En este trabajo se valida, mediante la técnica de los modelos de ecuaciones estructurales, un instrumento de medición que se utiliza para determinar si los datos recopilados son adecuados para verificar las hipótesis que indican la forma en que se relacionan las variables latentes o constructos con la variable “Elección de carrera” y “Universidad”. Para validar este instrumento de medición se conformó una muestra de 157 alumnos que cursan la carrera de ingeniería Industrial de la Universidad de Sonora. En los resultados se descubrió que las variables latentes o constructos siguientes: Costos económicos, Servicios, Imagen de la universidad e Infraestructura son apropiados para modelar la variable “Elección de carrera” mediante un modelo de ecuaciones estructurales.
Modeling in the field of freight transportation: ambivalence of management decisions in the conditions of quarantine restrictions and economic competition
Authors:   Lviv Polytechnic National University, Dvulit Zoryana , Maznyk Liana ,   National University of Food Technologies, Danyliuk Ivanna ,   Lviv Polytechnic National University
Published: June 2021

The study focuses on the ambiguity of management decisions in conditions of economic competition and quarantine restrictions. It is concluded that in the field of freight transportation there are antagonistic interests of the environment in the process of making management decisions by managers of JSC “Ukrzaliznytsia”. The classification of information situations related to the uncertainty of the environment is used, according to which the fifth information situation most closely corresponds to the current situation in the market of transport services. The choice of the fifth information situation is due to the factors caused by the government’s decisions to impose quarantine restrictions. Most of these factors have had a negative impact on the expectations of businesses in general and cargo owners in particular. The state of economic competition in the field of freight transportation was studied by analyzing the structure of goods by different modes of transport for January-November 2019-2020, indicating the absence of significant changes or restrictions on freight traffic. Thus, quarantine restrictions did not cause irreparable damage to the railway industry directly, but they indirectly affected a number of indicators. Analysis of economic competition, level of uncertainty, degree of ambivalence of government decisions and structural and dynamic analysis of the market of transport services in January-November 2019-2020, allowed creating a methodology that ensures the validity of management decisions in economic competition and ambivalence of government actions. It consists of 6 stages: formulation of the purpose; formation of the corresponding information base; formation of an expert group; direct survey; selection of the most promising solutions for stabilizing the situation in the field of rail freight; assessment of the homogeneity of the expert group. The application of this technique gives railway companies additional competitive advantages, even in conditions of growing uncertainty and risk.
Meaningfulness of basic factors of economic competition through the prism of the use of instruments of project management in an entrepreneurship
Authors:   Lviv Polytechnic National University, Samsonenko Maryna , Peredalo Khrystyna ,   Lviv Polytechnic National University, Oherchuk Yurii
Published: June 2021

The main factors of economic competition are considered, namely: people, time, money and quality. The ability to manage these factors through specific project management tools is reflected. The practical significance of each of the factors of economic competition is emphasized and the appropriate project management tool for the management of each of the factors on the example of companies in various sectors of the economy, based on research results or statistics. In particular, when considering the factor of economic competition "people", it is recommended to pay special attention to their role in improving the effectiveness of strategies implementation and changing the goal as a key quintessence of the organization, and for the development of this factor improved stakeholder assessment process is proposed, which is often used in project management to increase its competitiveness. Another tool in people management is analyzed - SCRUM teams, which have become especially popular globally. Research data on the level of their use in various areas of management are presented. To control the time parameter of economic competition, it is recommended to pay attention to the SMART technique, according to which the goals should be specific, measurable, achievable, relevant and limited in time. The importance of the "time" factor in the competitive environment is demonstrated by the example of postal companies and compared their level of competitive advantage according to this criterion, as well as those companies that responded quickly to restrictive measures during the Covid-19 pandemic and changed their priority projects to those that are more urgent today. Regarding the "quality" factor, analyzing the world's achievements, attention was paid to the effectiveness of using 14 principles of E. Deming, which still remain relevant. The "costs" factor is governed by classical and further tools such as budgeting and the popular E. Deming cycle. It is concluded that the use of various project management tools in the field of economic competition to increase the positive impact of its factors allows ensuring the desired level of competitiveness of the organization of any field of activity and at any stage of its life cycle. These tools are easy to use, versatile and practical.
English As Secondary Language Learning and Autism Spectrum Disorder: The Obstacles in Teaching and Learning the Language
Authors: Umiera Hashim Haida , Md Yunus Melor , Norman Helmi
Published: June 2021

To this date, there has been an increasing number of children across the globe diagnosed with an autism spectrum disorder. There has been much literature that discussed the issues and obstacles common learners face in their English language learning journey. Yet, not much spotlight and acknowledgment were given to the learners with Autism in their voyage of English language learning. In conjunction to that, this paper intends to investigate the obstacles that the learners with Autism face in their English as secondary language learning. In addition to that, teachers are not to be forgotten as teachers are also believed to be playing a role in learners with Autism’s English as a second language(ESL) learning process which is why this research also intends to investigate the challenges faced by the teachers who are in charge of teaching learners with Autism. A qualitative research with the observation and interview as the instruments represents this research. This research involved two Autism Centres located in an urban area in Malaysia. The observation and interviews were conducted with forty-five learners with Autism and fourteen teachers. The findings have gathered that the world of Autism Spectrum Disorder is indeed full of obstacles and challenges but none that could not be overcome. It is believed that this research will provide a better insight of the real world of ESL teaching and learning among learners with Autism. Discussions and recommendations are further explained in this research.