bluuebunny/crossref_metadata_2025 huggingface dataset:
Contextualized Social Science Learning Activities from Upland Corn Farming Practices: A Literature Review
Authors: - ALLEN A. TUBIG
Published: May 2024

The agricultural landscape of the Philippines, characterized by its rich natural endowments and tropical climate, has emerged as a cornerstone of socio-economic development, driven largely by small-scale farming practices. Despite its significance, challenges such as soil erosion and unsustainable farming practices persist in upland regions, necessitating a shift towards sustainable resource management. This literature review explores the contextualization of social science learning activities within agricultural frameworks, focusing particularly on upland corn farming practices. Drawing from a multidisciplinary approach, this study examines the evolutionary trajectory of agriculture, traditional farming methods, and their contemporary relevance in shaping educational paradigms. Through an analysis of educational initiatives and cultural practices, the review highlights the importance of integrating indigenous knowledge and traditional farming methods into educational frameworks. Key findings underscore the critical role of social science in promoting sustainable agriculture, community empowerment, and cultural preservation within farming communities. The review concludes by emphasizing the need for further research to bridge the gap between social science education and agricultural practices, particularly in upland farming communities, to advance sustainable agricultural development and preserve cultural heritage.
Effect of Catch Them Early Approach on Expository Reading Skills of Grade 7 Students
Authors: - Mary Ann M. Miranda
Published: May 2024

This study aimed to determine the effect of Catch them early approach on Expository reading skills of Grade 7 Students. Eventually, it also sought to determine the magnitude of effect of the action initiated by the researcher on the literary comprehension skills of the research subject. This study made use of the quasi -experimental design, I used non-equivalent control group pre-test-post-test design. Non- equivalent design is a good design when researcher has access to one group for experimentation. This study was conducted in Sto. Niňo National High School. The subjects of this study were 93 grade 7 students- 46 are section A which were the controlled group and 47 were from section B which were the experimental group. The composition of these two sections was heterogeneous therefore students of sections A and B had identical range of performance. The study utilized the researcher-made pretest and post-test which was the tool to measure the research skills of the grade 7 students. Topics covered were taken from the learning competencies in grade 7. Moreover, this study made use of the non-random assignment of subjects where all learners of both sections A and B were involved as subjects of the study. This study revealed that the use of catch them early approach has further developed the expository reading skills of the Grade 7 students. Finally, this study revealed that there is magnitude of the catch them early approach on expository reading skills of the research subjects.
Streamlining Business Operations through ERP Implementation
Authors: - Varad Prabhu , - Lance Fernandes , - Carl Mascarenhas , - Lyann Henriques , - Snehal Kulkarni
Published: May 2024

This research paper presents the design and implementation of an Enterprise Resource Planning (ERP) system, named Optiware, for Divine Enterprises. Divine Enterprises specializes in manufacturing Metal Springs, Lock Covers for IC Boards, and Cap Locks, catering to clients like Tata and Tech Mahindra. The primary objective of this project is to streamline Divine Enterprises’ business operations, automate various tasks, and eliminate the conventional paper-based record-keeping system. The proposed system majorly focuses on managing the business activities like accounting, inventory, human resources, supply chain by providing a full fledged ERP system. It also incorporates an automated inventory management module to enhance efficiency and comprehensive sales forecasting section employing various advanced algorithms, facilitating better decision-making, resource allocation, and overall business optimization.
Impact of GST on Retailers with Reference to Hosur City
Authors: - Dahesh Basumatary , - Dr. Suresh A S
Published: May 2024

The implementation of the Goods and Services Tax (GST) in many countries has brought about significant transformations in various sectors, particularly in the retail industry. This abstract outline a comprehensive analysis of the impact of GST on retailers. The study examines the effects of GST on retailers and how well they have understood it. It investigates how GST has influenced retailers' compliance burden, cash flow management, and profitability. Furthermore, the abstract explores the challenges faced by retailers during the transition to the GST regime, including administrative complexities, technology adoption, and adaptation to new tax structures. Drawing upon empirical evidence and theoretical frameworks, the analysis offers insights into the strategies adopted by retailers to navigate the complexities of GST implementation and leverage its potential benefits. It also shows the significant relationship between the educational status and awareness level of GST and sources of knowledge about GST. Overall, the study contributes to a deeper understanding of the transformative effects of GST on the retail sector and provides valuable insights for future research and policy development.
The Impact Of Training And Develpement On The Organizational Perfrormance Of Infosys
Authors: - Shruti Raj , - Prof. Snigdha Das
Published: May 2024

This research paper investigates how training and development initiatives at Infosys influence the overall organizational performance. Through a comprehensive analysis of existing literature, empirical data, and case studies, it explores the correlation between employee training programs and various performance metrics such as productivity, employee satisfaction, innovation, and profitability within Infosys. The abstract highlights key findings, suggesting that effective training and development programs positively contribute to enhancing employee skills, knowledge, and capabilities, thereby leading to improved organizational performance and competitiveness in the global marketplace. Additionally, it discusses implications for both theory and practice, emphasizing the importance of strategic investment in employee development for sustaining long-term organizational success
Monopolistic Competition and Market Positioning Strategies in Zimbabwe's Brewing Industry: Implications for Upgrading the Sorghum Value Chain.
Authors: - Tryphina Dube- Takaza , - Vuyiswa Sandrah Nyathi , - Blessing M Maumbe , - Cosmas Parwada
Published: May 2024

Zimbabwe’s brewing industry is characterized by monopolistic competition. The objectives of this study were to 1. Determine emerging competition for beer brewing industries in Zimbabwe 2. Describe market positioning strategies to enhance the performance of sorghum contracts. 3.Identify marketing challenges faced by farmers and brewing companies. The study was conducted in 4 districts (Binga, Chiredzi, Hwange, Matobo) that are situated in Natural Regions IV and V. A mixed methods cross-sectional study was used. A survey questionnaire was used to collect data from 281 respondents. A multistage sampling approach with purposive selection of districts dominant in small grain production was conducted. For each district, two wards were selected randomly. Porter’s five forces were used to assess the competitive strength and market positioning strategies of beer brewing companies. Results showed that Delta Corporation is the leading competitor among the brewing companies in Zimbabwe. There are few players in the beer industry. On market position strategies the industry uses product differentiation. Farmers have been faced with resource limitation whilst contracting companies have challenges in collecting low volumes of grain from farmers. Future prospects of beer industry of Zimbabwe are bright. There is need to lower entry barriers and promote competition among brewing firms
Unravelling the Complexities of Inoperable Glioblastoma Multiforme: A Comprehensive Review of Current Strategies and Future Directions
Authors: - Ishaan Bakshi , - Mallika Manish Pamnani , - Hriday Singh Rawat
Published: May 2024

Glioblastoma multiforme (GBM) remains one of the most challenging brain tumors to treat, particularly when surgical resection is not feasible due to tumor location or patient health status. This review explores recent advances and emerging therapeutic strategies for managing inoperable GBM. Current approaches encompass a combination of targeted molecular therapies, immunotherapy, and novel drug delivery systems to enhance efficacy while minimizing systemic toxicity. Moreover, the integration of advanced imaging techniques and precision medicine holds promise in identifying patient-specific vulnerabilities and tailoring treatments accordingly. Despite significant progress, the development of resistance mechanisms and tumor heterogeneity continue to pose formidable obstacles. Hence, future directions emphasize the exploration of innovative combinatorial therapies, including immunomodulatory agents and gene editing technologies, alongside ongoing efforts to unravel the molecular intricacies driving GBM progression. Through a comprehensive understanding of the tumor microenvironment and the dynamic interplay between tumor cells and the immune system, novel therapeutic paradigms aim to redefine the treatment landscape and improve outcomes for patients with inoperable GBM.
The Impact of Peer Pressure on Emotional Competence and Resilience among Young Adults
Authors: - Anushka Chaturvedi , - Dr Annie Khanam Singh
Published: May 2024

Peer pressure is a ubiquitous feature of human interaction that starts in youth and continues throughout maturity. It describes the power that members of the same social group have over one another, pressuring one another to adhere to the standards of the group by adopting particular
attitudes, behaviors, or beliefs. Emotional competence, which encompasses the ability to understand, regulate, and express emotions effectively, plays a vital role in individuals' overall well-being and interpersonal functioning (Brackett et al., 2006). Resilience is a fundamental concept of psychology, it enables people to adjust to and recover from hardship, tragedy, or extreme stress. It is not only the capacity to withstand adversity; it is also the ability to develop and flourish in the face of adversity.This study aims to explore the impact of peer pressure on emotional competence and resilience in individuals aged 18-26 years.
Active Learning Framework for Python Programming
Authors: - RENAMALA LOHITH KUMAR
Published: May 2024

the Dynamic Learning technique is utilized to progress the learning of the understudies within the classroom. To upgrade the venture execution aptitude of the understudies, one of the Comprehensive Courses was presented to be specific "Programming in Python" for the undergrad understudies of the Office of Computer Science and Designing. In this course, understudies carry out an extent of the concepts learned amid the course. Dynamic learning presented in this course made a difference in the students to lock in within the execution of ventures, week-by-week surveys, and discussions with peers to actualize the concepts learned within the classroom. The dynamic learning system made a difference in the resources to audit and assess the extended work. The result of dynamic learning made a difference in the understudies to fathom the issues with extended strategies than learning programming developed.
A Cloud-based Multimedia Storage Protection System
Authors: - Vaibhav Kharose , - Himanshu Mevada , - Yash Ambarle , - Tushar Devre , - Prof. Shatabdi Bhalerao
Published: May 2024

The rapid growth of digital media and the internet has revolutionized the way multimedia content is created, distributed, and consumed. However, this growth has also led to an increase in copyright infringement and unauthorized use of protected content, posing major difficulties for content creators and distributors. Traditional content protection methods are often inadequate in addressing these challenges, necessitating the development of more advanced and robust solutions.
Spam SMS Classifier using Machine Learning Algorithms
Authors: - AARYAN SHARMA , - HARSHIT KUMAR SIMBAL , - SMRITI KUMARI , - GAUTAM KUMAR , - HARSHVARDHAN KUMAR
Published: May 2024

Mobile SMS communication is insecure as a result
of a significant problem with spam detection. A technique or
model with high accuracy and precision is required to address
this spam SMS issue. The amount of spam emails has
dramatically increased over the last few years. SMS spam has
major negative impacts since it harms both consumers and
service providers, eroding their mutual trust to a great extent.
Different types of classifier algorithm have been implemented
like Naïve bayes, Random Forest, KNN and Support vector
classifier on a raw dataset collected from UCI repository in this
research. Metrices like Accuracy, Precision and Recall are
takes as performance metrics for calculating the efficiency of
the algorithm. After experimenting, the result of these
algorithms and compared them with another models. We
showed the comparison using Visualization Techniques.
Caracterização das pescarias artesanais existentes em Fernando de Noronha/PE, Brasil
Authors: Campos Zeineddine Gabriela , Alves Bennemann Ana Beatriz , Wasen Quesada Vitor , Vaske Junior Teodoro , Rosa Silva Julio
Published: May 2024

Este trabalho objetivou descrever as categorias de pesca realizadas em Fernando de Noronha, visando subsidiar o ordenamento pesqueiro, contribuir para a conservação da biodiversidade associada e a valorização da atividade pesqueira tradicional. Os dados foram coletados por meio de entrevistas realizadas no âmbito do monitoramento pesqueiro, e em reuniões de diagnóstico participativo com a comunidade pesqueira e gestores. Para melhor entendimento e caracterização da atividade, durante essas reuniões de diagnóstico, foi construída uma linha do tempo com as principais mudanças relacionadas Ã  pesca artesanal insular. Atualmente existem em média 94 pescadores em Fernando de Noronha, dos quais 35 realizam a pesca nas praias e 59 em barcos. A frota pesqueira é composta por 46 embarcações, porém apenas 19 são exclusivamente de pesca. De acordo com a lei da pesca, a atividade pesqueira local está inserida em quatro categorias de pesca: profissional, de subsistência, amadora e científica. As pescas de subsistência e profissional acontecem em maior frequência, porém a pesca amadora vem crescendo exponencialmente, através do turismo de pesca, uma atividade que faz interface entre a pesca profissional e amadora e, e por ser uma atividade relativamente nova, se encontra em um cenário oportuno para ordenamento. Este trabalho caracterizou os tipos de atividade pesqueira existentes em Fernando de Noronha. De acordo com a percepção das mudanças e aumento da pesca amadora (turismo de pesca), sugere-se que essa atividade seja ordenada de forma particular, com regras específicas que visam Ã  conservação dos recursos naturais explorados, além dos valores culturais e econômicos da comunidade.
The Interplay of Brand Gestalt, Word-of-mouth and Revisit Intention in the F&B Sector
Authors: Langitan Jentelino Silvester , Rondo Elannemay , Mandagi Deske W.
Published: May 2024

This research examines the influence of brand gestalt variables, especially the four dimensions, story, sensescape, servicescape, stakeholders, on word-of-mouth marketing and the revisit intention. This research has eight hypotheses with a sample size of 175 obtained from the distribution of questionnaires carried out in October and November 2023. The data obtained was analyzed using Structural Equation Modeling (SEM) assisted by the SmartPLS statistical program. The results obtained show that the brand gestalt dimensions that influence word of mouth marketing and interest in revisiting are only two dimensions, namely Stakeholder for word-of-mouth marketing and Story for interest in returning to visit. Additionally, the study found that the remaining six hypotheses did not yield significant influences. The results of this research can be a reference for the food and beverage sector so that it can improve the quality of its business by utilizing the results obtained.
Konsep Perpecahan Gereja Barat dan Gereja Timur Serta Implementasinya dalam Pertumbuhan Gereja Saat Ini
Authors: Zebua Eka Kurniawan
Published: May 2024

Artikel ini menjelaskan bagaimana perpecahan itu dapat terjadi sehingga dengan mengetahui apa yang menjadi penyebabnya maka penulis akan membuat suatu pemahaman dan penjelasan yang baru untuk dipaparkan. Perpecahan merupakan pokok permasalahan yang sangat penting dalam artikel ini untuk diketahui secara jelas. Perpecahan ialah keterpisahan yang terjadi antara kelompok yang satu dengan kelompok yang lain. Akan tetapi, perpecahan timbul karena memiliki aspek yang mempengaruhi setiap kelompok tersebut, diantaranya aspek politik, budaya, dan ekonomi. Dalam artikel ini, penulis menggunakan metode study literatur yang mengkaji buku, jurnal-jurnal yang dapat membantu penulis untuk dapat menguraikan isi yang akan dibahas. Hasil penelitian ini menjelaskan bahwa perpecahan gereja adalah suatu keterpisahan yang timbul karena ulah manusia itu sendiri sehingga mengalami konflik. Perpecahan gereja memberikan dua dampak bagi jemaat, yaitu dampak positif dan dampak negatif. Dampak yang timbul tersebut memberikan pengaruh yang besar bagi gereja untuk terus mencari apa penyebab terjadinya perpecahan tersebut. Oleh karena itu, perpecahan gereja memberikan dorongan bagi gereja saat ini untuk dapat bersatu dalam satu komunitas.
Manajemen Pendidikan Islam Berbasis Karakter di Pondok Pesantren Islahuddini Kediri Lombok Barat
Authors: Badrun Badrun
Published: May 2024

This research aims to explore and analyze the implementation of character-based Islamic education management at the Islahuddin Islamic Boarding School in Kediri and its impact on the formation of the morals and character of the students. The research method used is qualitative research with a descriptive analytical approach. Data was collected through participant observation, in-depth interviews, and document analysis. The results of the research show that the Islahuddin Kediri Islamic Boarding School has succeeded in implementing character-based Islamic education management through structured and integrated programs, including the habituation of Islamic values in daily activities, personality development, and the cultivation of noble character. The impact of this implementation can be seen in increasing moral awareness, responsible attitudes and high social awareness among students. These findings provide an important contribution in the development of character-based Islamic education management models in other Islamic educational institutions.
Peran dan Kedudukan Perempuan Dalam Laskar Hizbullah Pada Masa Resolusi Jihad Sebagai Wawasan Sejarah Lokal
Authors: Matingvan Elanda , Hariyono Hariyono
Published: May 2024

The Jihad Resolution period in Indonesia was an event where Muslims agreed to defend Indonesia's independence. At this time, almost all elements of society took part, including women. The role of women during the Jihad Resolution period included supporting Laskar Hezbollah. This role of women cannot be separated from women's organizations, mothers, wives, and other individuals. However, the role of women during this period is less discussed in history, especially through the dimensions of women's femininity itself. Therefore, the purpose of this research is to present the role of women in the perspective of struggle in general and women's historiography through the dimension of femininity. In examining this research, a historical qualitative research type with a historical or historiographic approach is used with data collection methods through interviews and literature studies. So that the results of the research show that women have a role in the front line through the perspective of the struggle at that time, and have a role in the back line through the dimensions of women's femininity that are set aside by the patriarchal culture at that time which views how the act of struggle should be. Women contributed directly or indirectly, consciously, or unconsciously participated in the struggle through the things they could and used to do. Things that women did that were seen as not important, but had a chain effect on Indonesia's independence. And how women's actions are synonymous with gentleness which becomes a strength for them to support fighters who need that side amid the chaos of war. Thus, the role of women became complex in times of war, not only on the front lines and rear lines but in society emotionally, socially, and morally.
Ekoliterasi Lingkungan Hidup dalam Alquran Perspektif M. Quraish Shihab
Authors: Agri Imam Habib , Zein Achyar
Published: May 2024

Religion has an important role in guarding progress in the millennial era, so that it can be in line with the goal of creating humans as civilization-building creatures based on environmental awareness. Studying environmental issues from a religious perspective is also an idea that needs to be followed up. The existence of religion is able to influence its adherents to do good and care about the environment, and can be used as an alternative solution in solving the issue of environmental damage. This research aims to explore environmental ecoliteracy in the Koran and analyze Quraish Shihab’s interpretation of the Koranic verse about environmental ecoliteracy. This research is descriptive-analytic in nature where the author analyzes Quraish Shihab’s understanding of his interpretation of verses related to environmental ecoliteracy. This study found that the environment in the Koran can be applied into three parts. First, related to the earth which includes water, wind and land. Second, related to flora, including plants and fruit. Third, related to fauna which includes livestock. Furthermore, there are two dimensions of ecoliteracy in Quraish Shihab's interpretation. First, the essence of ecoliteracy itself, namely concern for the environment in the form of caring for the earth. Second, in order to keep the earth sustainable, a prohibition was created on destroying nature. Quraish Shihab is a person who is aware of the environment, which is strengthened by Quraish Shihab's statement which emphasizes that protecting nature is part of the Shari’a.
Teaching essentials and optimization strategies of Honggu black pottery’s packaging design based on brand reconstruction
Authors: Sun Lifeng
Published: May 2024

Honggu black pottery, as a branch of characteristic ceramics in Gansu, , has broad market potential. Brand packaging design of black pottery is a key link in product design and development. From four aspects: teaching research, teaching reform concept, teaching essentials and optimization strategies, aiming at the packaging status of black pottery products in the market, this paper expounds the new development and teaching reform idea of marketing brand packaging design in packaging design teaching, and puts forward some optimization suggestions for the teaching reform practice of product brand packaging design.
An Exploration of Journal App Development Strategies Enabled by Augmented Reality (AR) Technology — Time Immersive, TIME’s periodical app, as an example
Authors: Zhou Bingquan
Published: May 2024

The report of the 20th Party Congress points out that it is necessary to implement the national cultural digitization strategy and enhance the influence of Chinese civilization’s dissemination power. In order to make better use of the advantages of augmented reality technology to promote the supportive role of journal App as a “new cultural infrastructure”, and to tell and disseminate Chinese stories with excellent Chinese journal App, this paper adopts the methods of case study and comprehensive analysis to explore the practice of TIME Immersive in TIME Weekly’s journal App TIME. Exploration. The analysis finds that TIME Immersive’s development design of “immersive interaction” and “non-incremental entity”, the content design of symbolic elements superimposed on medium and long stories, and the team building of breaking the circle of cooperation make TIME Immersive unique among the journal apps that combine augmented reality technology. The team building of TIME Immersive makes TIME Immersive have more outstanding advantages among a group of journal apps combining with augmented reality technology. Therefore, in the process of integrating with augmented reality technology, China’s journal apps can make new attempts in the three directions of interactive relationship, scene dissemination and service, and industry-university-research ecosystem, in order to incubate China’s high-quality digital journal apps and enhance China’s international influence.
The Relationship between the Images from Drone News and Audience Cognition and Empathy from the Perspective of Media Environment– A Case of the Russia-Ukraine War
Authors: Han Yan
Published: May 2024

Since the outbreak of the Russia-Ukraine War, multiple news medias around the world have introduced drones to continuously report this war from the perspectives of multi angles, which makes the reporting of Russia-Ukraine War War around the clock. These media agencies promotional strategy of a three-dimensional reporting, keeping drones simultaneously from high altitude with the control stations on the ground. As an audience, when watching news images from the ground and drone, we can clearly perceive the visual differences between them. However, the ground-based view of news coverage is limited, makes audience closely observe the details of war, which promotes threshold for understanding war for them. Compared to the ground news, drone news brings a greater visual impact to the audience, which in turn makes it easier for them to recognize the war and empathize with the people who suffered in the Russia-Ukraine conflict. This article is about the study the relationship between images collected by drone news and audience’s cognition and empathy from the theories of media ecology and empathy, with mainly research cases from reporting news on the Russia-Ukraine war.
Exploration and practice of ideological and political teaching in computer courses under the background of new era — taking Product prototype design as an example
Authors: Cao Yu , Liao Jiali , Zhang Huimin
Published: May 2024

College computer courses play a vital role in cultivating the professional ability and quality of new engineering students. It is indispensable to train new engineering talents with craftsman spirit for curriculum ideological and political construction. This paper explores the connotation and significance of thinking and politics in the course of computer major, takes “product prototype design” as an example, deeply excavates the elements of thinking and politics contained in the course content, explores the diversified model of adding blood, and aims to improve students’ computer professional ability and scientific literacy, so as to achieve the effect of education.
The Relationship between Perceived Social Support and Work Engagement among Kindergarten Teachers in Xizang
Authors: Peng Yinggang
Published: May 2024

The engagement of kindergarten teachers in their work significantly impacts the physical and psychological well-being of young children and the long-term development of preschool education. This study utilized a questionnaire survey with convenience sampling to select 846 kindergarten teachers from the Xizang region as research subjects. Measurements were conducted using the Social Support Scale, Professional Identity Scale, and Psychological Capital Scale. The findings reveal that the work engagement of kindergarten teachers in this sample was above the medium overall level. Significant differences in social support perception, professional identity, psychological capital, and work engagement were found based on individual background characteristics and the characteristics of the institutions where they worked. There were significant positive correlations between social support, professional identity, psychological capital, and work engagement among kindergarten teachers. Social support had a positive predictive effect on work engagement, while professional identity and psychological capital played a mediating role between social support and work engagement. To enhance the work engagement of kindergarten teachers, it is recommended to strengthen the mechanisms for ensuring social support, to create organizational environments that foster teachers’ psychological capital, and to enhance their sense of professional identity.
Enhancing diversity, equity, and inclusion within agricultural higher education: Insights from Black faculty and administrators in agricultural colleges at United States land grant institutions
Authors: Elbert Chanda D.
Published: May 2024

The experiences of Black faculty as leaders and administrators in the field of agriculture have not been widely studied nor reported. The goal of this research focused on Black faculty leaders' experiences in agriculture to gain firsthand insights regarding the enhancement of diversity, equity, and inclusion within agricultural higher education. The central research question guiding the study was: What are the experiences of Black faculty leaders at Colleges of Agriculture at Predominantly White Institutions (PWIs)? Counter-storytelling was used to explore the personal narratives of eight participants. These experiences fall within the tenets of Critical Race Theory. Three primary themes emerged: Navigating Leadership: Microaggressions in the Midst; Inequities: Is Everyone Really Equal; and Isolation: The Lone Ranger. Findings of this study hold valuable implications for practitioners, policymakers, and academic institutions seeking to enhance diversity, equity, and inclusion within agricultural higher education. Recommendations for policy and practice include providing support for leadership mentoring and professional development, conducting robust research on the intersection of race, ethnicity, and gender for faculty of color, and establishing collaborative initiatives between academic institutions, industry partners, and community organizations to address historical disparities and stimulate interest in agriculture among Black communities.
Evaluation of Prognostic Factors in Men with Germ Cell Tumors: 10 Years of Experience of the Russian Reference Centre
Authors: Проценко Светлана Анатольевна , Загоруйко Валентина Андреевна , Семенова Анна Игоревна , Абдуллаева Шейда Раджабали Кызы , Мурейко Екатерина Андреевна , Хидишян Карина Ервандовна , Телетаева Гульфия Мидхатовна , Новик Алексей Викторович , Латипова Дилором Хамидовна , Каспаров Борис Сергеевич , Носов Александр Константинович , Семиглазова Татьяна Юрьевна
Published: May 2024

Введение. Герминогенные опухоли (ГО) яичка — группа злокачественных новообразований, происходящих из зародышевых половых клеток. Несмотря на редкость данной патологии, ГО являются наиболее распространенным видом опухолей среди молодого мужского населения.
Цель. Изучение и поиск факторов неблагоприятного прогноза у больных ГО яичка.
Материалы и методы. Было включено 273 пациента с диагнозом ГО яичка, получавших лечение или неоднократную консультативную помощь в период с 2011 по 2021 гг. в ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России. Анализ выживаемости осуществлялся с помощью метода Каплана – Майера, регрессионный анализ с использованием метода Cox.
Результаты. Определены факторы, неблагоприятно влияющие на общую выживаемость (ОВ) при несеминомных ГО: наличие метастазов в легких (ОР 3,927, 95 % ДИ 1,051-11,111; p = 0,010), наличие нелегочных висцеральных метастазов (ОР 4,636, 95 % ДИ 1,710-12,570; p = 0,003), повышение уровня лактатдегидрогеназы (ЛДГ) ≥ 2,5 × верхней границы нормы (ВГН) (ОР 4,107, 95 % ДИ 1,614-10,451; p = 0,003), лечение в неспециализированном учреждении (ОР 2,73, 95 % ДИ 1,924-4,994; p = 0,003), отклонение от стандартов оказания медицинской помощи (ОР 3,731, 95 % ДИ 1,456-9,564; p = 0,006). Статистически значимыми факторами, влияющими на ОВ при семиномных ГО, явились наличие метастазов в легких (ОР 2,15, 95 % ДИ 1,024-6,877; p = 0,035) и повышение уровня ЛДГ ≥ 2,5 × ВГН (ОР 2,419, 95 % ДИ 2,015-8,775; p = 0,027). При многофакторном анализе, проведенного для всех больных ГО, фактором, влияющим на ОВ больных, оказалось отсутствие метастазов в легких (ОР 0,301, 95 % ДИ 0,100-0,910; p = 0,033).
Заключение. Определены факторы, неблагоприятно влияющие на прогноз заболевания у больных несеминомными и семиномными ГО. Получены сопоставимые данные по 3-х и 5-летней ОВ у больных, получавших лечение в ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России, в сравнении с международными данными.
Outcomes after Bronchoplastic Sleeve Resection in Comparison with Pneumonectomy for Non-small Cell Lung Cancer
Authors: Левченко Евгений Владимирович , Шабинская Виктория Игоревна , Левченко Никита Евгеньевич , Михнин Александр Евгеньевич , Мамонтов Олег Юрьевич , Ергнян Степан Мкртычевич , Хандогин Николай Владимирович , Слугин Евгений Николаевич , Юрин Роман Иванович , Лопушанская Ольга Олеговна , Бадаев Кирилл Дмитриевич
Published: May 2024

Цель. Сравнить результаты лечения немелкоклеточного рака лёгкого I-IIIB/C стадий после бронхопластических резекций и пневмонэктомий.
Материалы и методы. C 08.2006 по 08.2022 были собраны данные о 431 пациенте с первичным немелкоклеточным раком лёгкого I-IIIB/С стадий, которым в качестве оперативного этапа лечения была выполнена пневмонэктомия или бронхопластическая резекция. В анализ отобраны по 173 пациента в каждую группу. В качестве конечных точек приняты 30-дневная и 90-дневная послеоперационная летальность, безрецидивная и наблюдаемая (общая) выживаемость.
Результаты. При сравнении 30- и 90-дневной смертности статически значимых различий между группами не получено (р = 0,62 и р = 0,388 соответственно). При бронхопластических резекциях констатирована сопоставимая с пневмонэктомиями частота локального и регионарного рецидива (p = 1,000). Одногодичная безрецидивная выживаемость в группе бронхопластических операций составила 76 % против 72 % в группе пневмонэктомий, трехлетняя выживаемость — 59 % и 52 % соответственно, пятилетняя — 57 % и 46 % (p = 0,066). Наблюдаемая (общая) выживаемость составила 63,0 ± 16,84 (95 % ДИ: 30,0-96,0) мес. в группе бронхопластических резекций против 31 ± 5,4 (95 % ДИ: 20,41-41,59) мес. в группе пневмонэктомий (p = 0,014; HR = 0,703 [0,529-0,935]), общая 5-летняя выживаемость — 52 % против 38 %, 10-летняя — 29 % против 25 % соответственно.
Заключение. При сравнении таких показателей непосредственных результатов как 30-, 90-дневная послеоперационная смертность, были получены сопоставимые результаты. Безрецидивная выживаемость, в частности локальный контроль, сопоставима в сравниваемых группах. Бронхопластические резекции в долгосрочной перспективе улучшают показатели общей выживаемости в сравнении с пневмонэктомиями при всех стадиях, кроме IIIB/C.
Influence of the Timing of Surgery on the Long-term Outcomes in Patients with Locally Advanced Breast Cancer
Authors: Петровский Александр Валерьевич , Амосова Виктория Андреевна , Румянцев Алексей Александрович , Фролова Мона Александровна , Коваленко Елена Игоревна , Артамонова Елена Владимировна
Published: May 2024

Введение. В последние десятилетия отмечается неуклонный рост заболеваемости раком молочной железы (РМЖ). Несмотря на увеличение выявления РМЖ на ранних стадиях, по-прежнему значительная часть впервые выявленных случаев носят местно-распространенный характер. Подходы к лечению таких стадий претерпевали серьезные изменения, в результате которых общепринятым стандартом был признан комплексный (тримодальный) подход, включающий применение на первом этапе неоадъювантной лекарственной терапии и локальных методов (хирургическое лечение, лучевая терапия) на втором. При этом, несмотря на постоянно увеличивающийся объем знаний об эффективности и безопасности хирургических вмешательств, нерешенными остаются многие аспекты. В частности, открытым остается вопрос влияния сроков выполнения хирургического лечения на вероятность полной патоморфологической регрессии опухоли, а также отдаленные результаты лечения пациенток.
Цель. Выработать оптимальный подход к определению сроков выполнения хирургического этапа лечения после завершения неоадъювантной химиотерапии у пациенток с местно-распространенным раком молочной железы.
Материалы и методы. В данной̆ работе представлен ретроспективный сравнительный анализ данных пациентов с местно-распространенным РМЖ со стадией опухолевого процесса IIIA-IIIC, проходивших обследование и лечение в НИИ клинической онкологии ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России в период с 2000 по 2020 гг. На первом этапе всем больным была проведена неоадъювантная химиотерапия и/или эндокринотерапия, далее — хирургическое лечение. В работе описано влияние сроков хирургического лечения на частоту полной патоморфологической регрессии опухоли у пациенток с различными подтипами РМЖ; а также на безрецидивную выживаемость и частоту развития хирургических осложнений.
Результаты. По результатам проведенного многофакторного анализа было показано независимое негативное влияние временного интервала (> 42 дней) до проведения хирургического лечения на вероятность констатации полной патоморфологической регрессии опухоли (р = 0,049). Факт позднего проведения хирургического вмешательства также снижает показатели безрецидивной выживаемости пациенток, в первую очередь, при высокоагрессивных опухолях молочной железы (тройной негативный, люминальный и нелюминальный HER2-позитивный варианты, р = 0,026). Кроме того, выявлено, что выполнение хирургических вмешательств в ранние сроки (до 21 дня) после завершения неоадъювантной химиотерапии ассоциируется с достоверным повышением рисков хирургических осложнений (14,5 %, р = 0,009).
Заключение. Результаты нашего исследования позволили определить оптимальные сроки выполнения хирургического вмешательства у больных местно-распространенным РМЖ.
Characterization of Tumor Angiogenesis in Gastric Carcinomas at Different Stages of Their Progression
Authors: Греков Илья Сергеевич
Published: May 2024

Введение. Биологическое поведение опухоли во многом зависит от особенностей сосудистого русла и моделей опухолевого ангиогенеза. Изучение морфологии сосудов позволяет не только улучшить прогнозирование раннего метастазирования, но и разработать более эффективные методы лечения.
Материалы и методы. Изучено 55 случаев рака желудка (РЖ) различного гистологического строения по классификации P. Lauren. Для иммуногистохимического исследования использовались антитела к панцитокератину АЕ1/АЕ3, цитокератинам 17, 18, виментину, E-кадгерину, альфа-гладкомышечному актину (α-ГМА), CD31, CD34, Кі67. Оценивалась длина, морфология и плотность сосудистого русла опухоли, количество, характер и особенности стромы. Выявили морфологические признаки эпителиально-мезенхимальной трансформации (ЭМТ), полноту и распространенность данного процесса в опухоли, и сопоставили с ангиогенезом.
Результаты. В опухоли кишечного типа мало предсуществующих сосудов с полноценно построенными стенками. Обнаружен выраженный полиморфизм, большинство сосудов тонкостенные, синусоидного типа. Превалируют случаи с большой плотностью сосудистого русла. Не найдена связь между плотностью сосудистого русла и стадией заболевания (р = 0,779 по критерию хи-квадрат). В опухоли превалирует очаговая неполная ЭМТ. В диффузном РЖ мало предсуществующих сосудов с полноценными стенками. В части сосудов эндотелий экспрессировал CD34 без экспрессии CD31. В эндотелии нет признаков пролиферативной активности. Во всех случаях ЭМТ чаще распространенная и неполная, реже обнаруживается полная ЭМТ. Строение сосудов в опухолях смешанного типа различное, мало сосудов с полноценно построенной стенкой. Чаще сосуды имели строение синусоид, тонкостенных щелей с просветами неправильной формы. В РЖ смешанного типа плотность русла была выше в участках недифференцированного рака, в сравнении с более дифференцированной аденокарциномой. Преобладают случаи с очаговой неполной ЭМТ.
Заключение. Сосуды отличаются большим разнообразием в морфологическом, функциональном и иммуноморфологическом профилях, что влияет на поведение опухоли в целом. В РЖ кишечного типа на инвазию опухоли в большей степени влияет плотность сосудистого русла, и менее — распространенность и полнота ЭМТ. В РЖ диффузного типа плотность сосудов играет меньшую роль для инвазии, чем распространенность ЭМТ, а также большая частота полной ЭМТ. В смешанном РЖ на инвазию сосудов влияет большая плотность сосудистого русла и полнота ЭМТ.
Exploring the Role of Felt Experience and the Autonomic Nervous System in Human Service Interactions
Authors: Edlins Mariglynn
Published: May 2024

Human service interactions have long been explored through a focus on what happens in these interactions: who participates, what is said and done, and the outcomes that emerge. However, recent political, environmental, and socio-economic shifts highlight the ways a focus on the mere facts of an interaction may not be adequate in understanding what occurs in human service interactions and why, especially if the goal is to improve these interactions. In order to create more resilience in human service interactions and to account for how recent crises impact interactions, there is an opportunity for public and nonprofit institutions to focus in on individuals’ experience of human service interactions, as well as to consider how that experience shapes outcomes. This paper draws on multidisciplinary research to explore felt experience, as shaped by individuals’ autonomic nervous system, as a significant factor and potential determinant of human service interactions.
Arkansas Domestic Violence shelters: Resilience in the Face of Multiple Challenges
Authors: Overholser Amber , Kelton-Huff Jennifer
Published: May 2024

Domestic violence occurs with far too much frequency, with an average of 24 people per minute being victims of rape, physical violence or stalking by an intimate partner in the United States (The National Coalition Against Domestic Violence, n.d.). Domestic violence shelters are typically 501c3 nonprofits which provide services to victims fleeing violence. This paper explores how shelters within the state of Arkansas have exhibited resiliency over the course of the recent COVID-19 pandemic and the 40% cuts required due to changes in the Crime Victims Fund (CVF), the primary source of funding for most shelters. Our findings reveal varied abilities to respond to these co-occurring stressors and found that contracting COVID-19, fears about closing, concerns over victims, and especially funding, weighed heavily on the minds of shelter staff We also found that shelter staff who stayed were resilient, fully invested in their organizations and the clients they serve, and looking onward to the future.
Gender and Work-Life Balance during COVID-19: A Study of Public Affairs Faculty
Authors: Medina Pamela S. , Azevedo Lauren , Shi Wanzhu , Bagwell Matt T.
Published: May 2024

Women have faced disproportionate negative health and economic impacts from COVID-19. This study explores gender differences in work-life balance among female and male public affairs faculty during the pandemic. Drawing on social role theory and the theory of gendered organizations, we survey faculty from the 176 NASPAA accredited schools to examine how gender, workload, institutional support, and domestic responsibilities impacted work-life balance during the early months of the COVID-19 pandemic. Results suggest that work-life balance was impacted in different ways by gender, domestic responsibilities, workload (teaching, research, and service), and institutional support policies related to the pandemic. An examination of qualitative data from faculty surveys revealed that increased demands, including homeschooling, childcare, domestic responsibilities, among other demands, lowered work life balance satisfaction. Several recommendations are made for addressing work-life imbalances and gender differences among higher education administration practitioners.
Gender and Work-Life Balance During COVID-19: A Study of Public Affairs Faculty
Authors: Medina Pamela S. , Azevedo Lauren , Shi Wanzhu , Bagwell Matt T.
Published: May 2024

Women have faced disproportionate negative health and economic impacts from COVID-19. This study explores gender differences in work-life balance among female and male public affairs faculty during the pandemic. Drawing on social role theory and the theory of gendered organizations, we survey faculty from the 176 NASPAA accredited schools to examine how gender, workload, institutional support, and domestic responsibilities impacted work-life balance during the early months of the COVID-19 pandemic. Results suggest that work-life balance was impacted in different ways by gender, domestic responsibilities, workload (teaching, research, and service), and institutional support policies related to the pandemic. An examination of qualitative data from faculty surveys revealed that increased demands, including homeschooling, childcare, domestic responsibilities, among other demands, lowered work life balance satisfaction. Several recommendations are made for addressing work-life imbalances and gender differences among higher education administration practitioners.
Impacts of Efficiency Targeting in School Aid on School District Efficiency, Student Performance, and Outcome Equity
Authors: Ryu Jay E.
Published: May 2024

Efficiency targeting in school aid to school districts penalizes inefficiency by decreasing school aid especially when its target value is set closer to full efficiency, which drives inefficient school districts to enhance efficiency in school administration and teaching. Simulation results for local Ohio school districts from 2011 to 2019 indicate that stringent efficiency targeting improves school district efficiency by about 0.7 to 4 percent. Efficiency targeting also enhances student performance by about 0.5 to 2.7 percent. This paper additionally confirms a tradeoff between efficiency and school aid. It is likely that poorer school districts are already economizing on educational spending and their actual efficiency scores tend to be higher than those of their less efficient counterparts. In addition, poorer districts receive relatively larger school aid under typical foundation aid formulas. As the efficiency target value increases, which lowers school aid to them, a disproportionately larger amount of school aid would be cut for poorer districts. However, the drop-off in school aid further triggers them to enhance efficiency and the increased efficiency translates into higher educational outcomes. Under some ranges of efficiency targeting, efficiency, student performance, and outcome equity can improve.