bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of left ventricular hypertrophy on the outcome of coronary artery bypass grafting
Authors: Admin  , Mohamed Magdy Abd Elalim  , Amr Abdou Ettish  , Wael Mohamed Elfeky  , Mohamed Moustafa Abdelaal  , , Reda Biomy Basttawesy
Published: June 2023

Objective: To evaluate the relationship between left ventricular hypertrophy (LVH) and coronary artery bypass grafting (CABG) procedure especially on the early outcome during the first 6 months following surgical intervention Methods: This prospective cohort study included 82 patients with coronary artery disease indicating CABG. These patients were admitted, operated and followed -up in cardiothoracic surgery departments in the faculty of medicine, Kafrelsheikh university hospitals in the period from April 2019 till November 2021.The patients included in this study were divided into two groups according to presence or absence of left ventricular hypertrophy, Group I had 38 (46.34%)patients with LVH and Group 2 had 44 (53 .65%). patients without LVH.Results: The time to regain mechanical activity was longer (5.76±1.82) minutes in LVH patients (p <0.001). LVH group had a significantly longer period of mechanical ventilation 16.50±4.25 hours (p <0.001) compared to non LVH group which was 9.61±3.78 hours. Also, the mean duration of ICU stays in the LVH group compared to the non LVH group was 3.81±1.20 days versus 2.56±0.81 days respectively. The ICU follow up showed a statistically significant relationship of arrhythmias with LVH (p =0.022), infections (p =0.005) and wound infections (p<0.001).
Conclusion: In patients undergoing CABG surgery, LVH has been associated with increased morbidity and pooroutcome.Keywords: Hypertrophy, left ventricular, coronary artery disease, respiration, artificial, coronary artery bypass, morbidity, wound Infection, arrhythmias, cardiac DOI
Topical lidocaine and or/ intravenous midazolam before radial coronary angiography to prevent radial artery spasm
Authors: Mohamed Zakariya Elattar  , Reda Biomy Bastwisy  , Wael Anwar Haseeb  , Mohamed Kamal Salama
Published: June 2023

Objective: To investigate the possible advantage of topical lidocaine and intravenous midazolam in preventing spasm and pain related to the radial artery.Methods: The prospective, comparative study was conducted at the catheterization laboratory of the cardiology department Kafrelsheikh University Hospital, Egypt, from January 2021 to January 2022, and comprised adult patients of either gender who were due to undergo coronary angiography and/or percutaneous coronary intervention for different indications. The patients were randomised control group I which was administered a cocktail of nitroglycerine, verapamil and heparin, intervention group II which was administered the control cocktail plus topical lidocaine, group III which was administered the control cocktail plus midazolam intravenously, and group IV which was administered the control cocktail plus topical lidocaine and intravenous midazolam. The groups were compared for frequency of radial artery spasm, access site cross-over and the difference in occurrence as well as procedure events, including the puncture number, time and complications. Data was analysed using SPSS 25.Results: Of the 120 patients, there were 30(25%) in each of the 4 groups. Overall, there were 72(60%) males and 48(40%) females. Gender and mean age were not significantly different among the groups (p>0.05). Spasm of the radial artery occurred in 22(18.3%) patients, with higher incidence in the group I 12(40%). The median visual analogue scale score was higher in patients with radial artery spasm patients (p<0.001). The groups showed no significant differences in terms of frequency related to ad hoc percutaneous coronary intervention, contrast volume and fluoroscopy time (p>0.05), while they showed a significant difference in puncture time (p<0.05). Significant differences were noted among the groups in the incidence of radial artery spasm, visual analogue scale scores, requirement ofmultiple punctures, and the number of indicated punctures (p<0.05). Access site cross-over was more in the group I, while age, complication rates, visual analogue scale score, incidence of multiple punctures, and puncture time were significantly higher in patients with radial artery spasm (p<0.05).Conclusion: Cutaneous analgesia and procedural sedation before transradial access for coronary interventions were found to be associated with a substantial reduction in radial artery spasm and procedure-related discomfort.Keywords: Coronary intervention, Transradial access, Radial artery spasm, Topical lidocaine, Intravenous midazolam
Gremlin-1 level in polycystic ovary syndrome and its clinical correlations; A case control study
Authors: Ahmed Mohamed Abdelkarim  , Ahmed Youssef Rezk  , Nahla Abd El Azeez Nosair  , Mostafa Farag Ellakany  , Ahmed Mohamed Fathy
Published: June 2023

Objective: To evaluate the involvement of the level of Gremlin-1 in serum and follicular fluid in the diagnosis of polycystic ovary syndrome.Methods: The case-control study was conducted at the Kafrelsheikh University Hospital, Egypt, from September 2021 to February 2022, and comprised women with polycystic ovary syndrome and healthy controls. All participants were subjected to a detailed clinical assessment, complete clinical examination and hormonal profile assessment. Gremlin- 1 concentrations in plasma and follicular fluid samples were assessed by a double-antibody sandwich enzyme-linked immunosorbent assay kit. Data was analysed using SPSS 20.Results: Of the 90 subjects, 45(50%) were patients with a mean age of 29.53±4.82 years, and 45(50%) were controls with a mean age of 30.89±6.08 (p>0.05). Mean weight, body mass index, waist circumference and waist-hip ratio were significantly higher in patients compared to controls (p<0.05). Serum and follicular fluid Gremlin-1 levels were significantly higher in the patient group (p<0.05). The best cutoff of serum Gremlin-1 in the diagnosis of polycystic ovary syndrome was ≧1.325ng/ml with area under curve 0.857, sensitivity 93.3%, specificity 68.9%, positive predictive value 75%, negative predictive value 91.2% and overall accuracy 81.1%. The best cutoff of follicular fluid Gremlin-1 inthe diagnosis of polycystic ovary syndrome was ≧1.725ng/ml with area under curve 0.789, sensitivity 73.3%, specificity 68.9%, positive predictive value 70.2%, negative predictive value 72.1% and overall accuracy 71.1%.Conclusion: There was a strong correlation between serum and follicular Gremlin-1 levels in polycystic ovary syndrome patients.Keywords: Polycystic ovary syndrome, Hyperandrogenism, Follicular fluid, Anovulation, Predictive value, Infertility.
Assessment of endometrial integrin beta 5 in women with unexplained recurrent pregnancy loss
Authors: Ahmed Mohamed Fathy  , Ahmed Youssef Rizk  , Nahla Abd El Azeez Nosair  , Ahmed Mohamed Abdelkarim  , Mostafa Farag Ellakany
Published: June 2023

N/A
Clinicopathological value of epidermal growth factor receptor (EGFR) and Ki-67 expression in colorectal adenoma and adenocarcinoma
Authors: Eman Mohamed Ahmed Nor  , Eman Mohamed Saied  , Samir Nemr Mina  , Mohamed Mostafa Shareef  , Dareen Mohamed Abdelaziz
Published: June 2023

Objective: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma and carcinoma cases, and to relate their expression with the available clinicopathological data.Methods: The retrospective study was conducted at the Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 to October 2020, and comprised formalin-fixed and paraffin-embedded specimens related to cases of colorectal adenoma and those of colorectal carcinoma, who had no previous radiation or chemotherapeutic treatment. Immunohistochemical staining of all thecases was done using anti-epidermal growth factor receptor and anti-Ki-67 antibodies. Data was analysed using SPSS 20.Results: Of the 70 cases, 20(28.5%) were of colorectal adenoma; mean age 52.95±13.47 years, and male-to-female ratio 1:1. The remaining 50(71.5%) cases had colorectal carcinoma; mean age 51.08±13.49 years, and male-to-female ratio 1.17:1. Epidermal growth factor receptor and Ki-67 overexpression related significantly to villous histopathological type and high-grade dysplasia in colorectal adenoma cases (p<0.05). In colorectal carcinoma cases, epidermal growthfactor receptor overexpression related significantly to tumour grade (p<0.05). Ki-67 overexpression related significantly to increased pathological stage (p<0.05).Conclusions: Overexpression of epidermal growth factor receptor and Ki-67 was found to be an ominous sign of colorectal adenoma aggressiveness, and the risk of progression to colorectal carcinoma.Keywords: Antigen, Adenoma, Colorectal neoplasms, Receptors, Carcinoma.
Evaluation of left ventricular function after sofosbuvir and daclatasvir regimen for chronic hepatitis C
Authors: Kareem Ali Maher  , Reda Biomy Bastawesy  , Mahmoud Mohammed Youssef  , Wael Anwar Haseeb  , Mariam Salah Zaghloul
Published: June 2023

Objectives: To assess left ventricular functions by echocardiography after 12 weeks of sofosbuvir-daclatasvir combination therapy.Method: The prospective cohort study was conducted from December 2019 to December 2021 at Kafrelsheikh University Hospital, Egypt, and comprised adult patients of either gender who had been referred to the Cardiovascular Department for cardiac evaluation and were found to be eligible for sofosbuvir-daclatasvir combination therapy. The patients were classified into five groups according to cardiovascular risk factors. Group 1 had no risk factors; Group 2 had many risk factors; Group 3 had only hypertension; Group 4 had diabetes only; and Group 5 had smoking as the only risk. All patients were assessed at baseline and at the end of the 12-week of antiviral combination therapy sofosbuvir 400 mg once daily dose and daclatasvir 60 mg once daily dose. Parameters checked were left ventricular ejection fraction, global longitudinal strain, wall motion abnormalities and diastolic function. Data was analysed using SPSS 23.Results: Of the 200 patients, 104(52%) were females and 96(48%) were males. The age range was 34-81 years, and 18(9%) patients were aged >70 years. There were 78(39%) patients in Group 1, 60(30%) in Group 2, 25(12.5%) in Group 3, Group 4 had 13(6.5%) and Group 5 had 24(12%) patients. There were no significant changes in mean ejection fraction, global longitudinal strain and wall motion abnormalities (p>0.05). Diastolic function had some significant parameters in each of the 5 groups (p<0.05).Conclusion: Sofosbuvir-daclatasvir combination therapy did not affect or impair left ventricular systolic or diastolic functions.Keywords: Stroke, Sofosbuvir, Antiviral, Hepatitis C, Chronic, daclatasvir, Coronary syndrome, Cardiovascular diseases, Echocardiography, Amiodarone, Recurrence, Smoking.
Cardiovascular Risk Assessment after Sofosbuvir and Daclatasvir Regimen for Chronic Hepatitis C Virus Infection
Authors: Kareem Ali Maher  , Reda Biomy Bastawesy  , Mahmoud Mohammed AbdouYossef  , Mariam Salah Zaghlol  , Wael Anwer Haseeb
Published: June 2023

Objective: To assess cardiovascular risk after sofosbuvir and daclatasvir antiviral combination therapy in chronic hepatitis C virus patients.Methods: The prospective cohort study was conducted at the Kafrelsheikh University Hospital, Egypt, from December 2019 to December 2021, and comprised adult patients of either gender with chronic hepatitis C virus and with minimum ejection fraction 40%. They were classified into groups according to their cardiovascular risk. Group 1 had individuals with no risk factors, Group 2 had patients with many risk factors, Group 3 had patients with only hypertension, Group 4 had those with diabetes alone, and Group 5 comprised smokers. All the patients were evaluated for the risk of major cardiovascular events at baseline and at the end of 12-week of antiviral combination therapy of sofosbuvir 400 mg once daily dose and daclatasvir 60 mg once daily dose. Data was analysed with SPSS version 23.Results: Of the 200 patients, there were 96(48%) males and 104(52%) females. The age ranged 34-81 years. There were 78(39%) patients in Group 1; 20(25.6%) males and 58(74.4%) females with mean age 54.4±10.45 years. Group 2 had 60(30%) patients; 40(66.6%) males and 20(33.3%) females with mean age 59.57±9.1 years. Group 3 had 25(12.5%) patients; 3(12%) males and 22(88%) females with mean age 61.4±7.8 years. Group 4 had 13(6.5%) patients; 10(77%) males and 3(23%) females with mean age 55.4±10.4 years. Group 5 had 24(12%) patients who were all (100%) males with mean age 60.7±5.7 years. There were non-significant changes in the incidence of angina, arrhythmias or progression of dyspnoea (p>0.05). Echocardiography follow-up results showed non-significant changes in meanejection fraction, global longitudinal strain and pulmonary artery pressure (p>0.05).Conclusion: Sofosbuvir and daclatasvir combination therapy was found to be safe in chronic hepatitis C virus patients regarding cardiac risks.Keywords: Sofosbuvir, Daclatasvir, Stroke, Pulmonary, coronary syndrome, Cardiovascular, Hepatitis C, Ventricular dysfunction, Echocardiography, Amiodarone, Hypertension, Arrhythmias, Diabetes, Dyspnoea, Smoking.
Can speckle tracking of right ventricle add value for evaluation of asthma severity in children?
Authors: Ahmed Mohammad Abbas  , Hany Hussein Mousa  , Reda Biomy Bastawesy  , Osama Elagamy
Published: June 2023

Objective: To investigate myocardial deformation by tracking speckles along with evaluation of cardiac function using conventional and tissue Doppler imaging.Method: The case-control study was conducted at Kafrelsheikh University Hospital, Egypt, from September 2019 to May 2022, and comprised asthmatic children and healthy controls matched for age and gender. After taking family history of asthma, assessments were made for bronchial asthma treatment and severity. Clinical examination and pulmonary function tests were performed along with tissue Doppler imaging and speckle tracking. Global left ventricular and right ventricular strains were measured. Data was analysed using SPSS 22.Results: Of the 120 subjects, 60(50%) were cases; 33(55%) males and 27(45%) females with mean age 9.4±2.91 years. The remaining 60(50%) were controls; 34(56.7%) males and 26(43.3%) females with mean age 9.7±2.99 years (p>0.05). Among the cases, 36(60%) had moderate severity and 24(40%) had mild asthma. Family history was positive in 11(18.3%) cases and negative in 49(81.7%). There was no significant difference in terms of conventional echocardiography between the groups (p>0.05). There was impairment in right ventricular diastolic function in the cases, with lateral tricuspid E` velocity significantly lower (p<0.05) and isovolumetric relaxation time significantly higher than the controls (p=0.001). There was impairment of systolic function of the right ventricle in the cases compared tothe controls (p=0.001). Right ventricular peak longitudinal systolic stress cut-off value distinguishing the controls from the cases was -20.4 with sensitivity 85% and specificity 63%. The cut-off value distinguishing mild from moderate asthmatic cases was -19.8 with sensitivity 83% and specificity 91%.Conclusion: Speckle tracking echocardiography could detect very early subtle right ventricular systolic dysfunction. Right ventricle dysfunction worsened with the severity of asthma.Keywords: Hypertension, Pulmonary, Echocardiography, Respiratory, Asthma, Hypoxia.
Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients
Authors: Asmaa Embarak Hassan  , Nahla Abdelaziz Nosair  , Mohammed Hussien Ahmed  , Dalia Elsayed Sherif  , Eman Mohammad Habib  , Nahla Farahat
Published: June 2023

Objective: To investigate the relation involving soluble interleukin-2 receptor, interleukin-6 and interleukin-10 in hospitalised patients with severe coronavirus disease-2019 infection.Methods: This single-centre cohort study was conducted at the Kafrelshiekh University Hospital, Egypt, from January to June 2022, and included all patients of either gender who were hospitalised with severe infection with the coronavirus disease-2019 isolation ward. Chemiluminescence immunoassay method was used to measure levels of procalcitonin, ferritin, soluble interleukin-2 receptor, interleukin-6 and interleukin-10. Data was analysed using SPSS version. 25Results: Of the 250 patients with median age 57.5 years (interquartile range: 45.8-66.0 years), 147(59%) were males and 103(41%) were females. Of them, 102(40.8%) patients died; 68(66.7%) males, 34(33.3%) females, median age 60.0 years (interquartile range: 48.8-70.0). Among the 148(59.2%) survivors, 79(53.4%) were males and 69(46.6%) were females, while the overall median age was 55.0 years (interquartile range: 41.5-65.8 years). The survivors had significantly lower levels of soluble interleukin-2 receptor, interleukin-6 and interleukin-10 (p<0.001). Correlation analysis identified significant positive correlation between IL-2R, IL-6 and IL-10 levels and almost all the inflammatoryand coagulation parameters, including C-reactive protein, lactate dehydrogenase, procalcitonin, ferritin, D-dimer and fibrinogen (p<0.05).Conclusion: Elevated levels of soluble interleukin-2 receptor, interleukin-6 and interleukin-10 were found to be associated with greater risk of mortality in coronavirus disease-2019 patients.Keywords: Interleukin-6, Interleukin-10, Procalcitonin, Fibrin fragment D, COVID-19, Luminescence, Interleukin-2, Immunoassay, Fibrinogen, Ferritins
Long noncoding RNA GAS5 and miR-137 and two of their genetic polymorphisms contribute to acute ischemic stroke risk in an Egyptian population
Authors: Doaa Taha.Ahmed Elsabagh  , Olfat Gamil Shaker  , Hanan. Helmy Elgendy  , Marwa Mohammad Mona  , Amul Mohammad.Abd ElRahim Badr
Published: June 2023

Objectives: To assess the serum expression levels of long non-coding ribonucleic acid growth arrest specific-5 and micro-ribonucleic acid-137, and the different genotypes of long non-coding ribonucleic acid growth arrest specific-5 rs2067079 (C>T) and micro-ribonucleic acid-137 rs1625579 (T>G) in acute ischaemic stroke patients.Methods: The case-control study was conducted at Cairo University, Cairo, Egypt, from January to August 2020, and comprised adult acute ischaemic stroke patients of either gender selected from the stroke unit of the Neurology Department at Kasr Alainy Hospital of Cairo University. Healthy individuals matched for age and gender were enrolled as controls. Quantitative real-time polymerase chain reaction was used to quantify serum expression levels of long non-coding ribonucleic acid growth arrest specific-5 and micro-ribonucleic acid-137, and to genotype long noncoding ribonucleic acid lncRNA growth arrest specific-5 rs2067079 and micro-ribonucleic acid-137 rs1625579 usingTaqMan allelic discrimination. Data was analysed using SPSS 22.Results: Of the 100 subjects, 50(50%) were patients; 34(68%) males and 16(32%) females with mean age 60.4±10.0 years. The remaining 50(50%) were controls; 28(56%) males and 22(44%) females with mean age 56.9±12.2 years (p>0.05). The patients had more smokers, more hypertensives and more diabetics than the controls (p<0.05). Long non-coding ribonucleic acid growth arrest specific-5 expression levels were significantly increased, while microribonucleic acid-137 expression levels were significantly reduced among the patients (p<0.05). Acute ischaemic stroke risk was significantly higher in patients with growth arrest specific-5 rs2067079 (C>T) recessive model (homozygousminor TT genotype), while micro-ribonucleic acid-137 rs1625579 (T>G) was protective against acute ischaemic stroke in allelic (G minor allele), codominant (GT genotype), dominant (GT+GG), and over-dominant (GT genotype) models (p<0.05).Conclusion: Long non-coding ribonucleic acid growth arrest specific-5 rs2067079 and micro-ribonucleic acid-137 rs1625579 may act as novel genetic markers of acute ischaemic stroke risk.Keywords: RNA, Polymorphism, Nucleotide, Alleles, Genetic, Ischemic stroke, Transcriptase polymerase, MicroRNAs, Genotype.
The effect of interleukin-6 and procalcitonin level on the development of oral manifestation in hospitalized COVID-19 patients
Authors: Enas Ahmed Elgendy  , Ahmed Mohammad Ali Elgendy  , Marwa Sabry  , Mohamed Kamal Salama  , Tamer Aboshady
Published: June 2023

Objective: To evaluate the effect of interleukin-6 and procalcitonin levels in plasma on the development of oral manifestation in patients of coronavirus disease-2019.Methods: The case-control study was conducted from January to September 2021 at Kafrelsheikh University Hospital, Egypt, and comprised severe coronavirus disease. One hundred patients of either gender aged 30-60 years were included. The patients were divided into two equal groups, with group I having patients with oral manifestations, and group II had those without any oral symptoms. Plasma samples from both the groups were used to determine serum interleukin-6 and procalcitonin levels using electrochemiluminescence immunoassay. Data was analysed using SPSS 20.Result: Of the 100 patients, 50(50%) were in each of the two groups. Group I had 29(58%) males and 21(42%) females with overall mean age 44.83±6.12 years. Group II had 26(52%) males and 24(48%) females with overall mean age of 43.68±4.62 years. Interleukin 6 was significantly high in group I than in group II (p<0.05), while there was no significant difference between the groups for procalcitonin level (p>0.05).Conclusion: Interleukin-6 level could play an important role in the development of oral manifestation in coronavirus disease-2019 patients.Keyword: Interleukin, Procalcitonin, Ageusia, COVID-19, Gingivitis, Candidiasis, Mucous membrane, Immunoassay.
Effect of brain GYM exercises on balance in preschool children: a randomized controlled trail
Authors: Samar Taher Elbasuony Elbanna  , Hebatallah Mohamed Kamal  , Emad Abdul Maksoud Mahgoub  , Shorouk Elshennawy
Published: June 2023

Objectives: To investigate the effect of Brain Gym exercise on preschool children’s balance achievement.Method: The randomised controlled trial was conducted at EL-Moasis kindergarten from May to September 2021 and comprised preschool children of either gender aged 4-6 years who were randomised into intervention group A which received Brain Gym exercise for 15-30 minutes per day, three times a week, for eight consecutive weeks, and control group B which received the usual kindergarten activities. Balance was assessed by One Leg Standing Test and Functional Reach Test. Data was analysed using SPSS 20.Results: Of the 30 subjects, 15(50%) were in each of the 2 groups. There were 13(43.3%) boys and 17(56.7%) girls with overall mean age 4.99±0.67 years. However, the study completed had 27(90%) subjects. Overall, there were 26(%) right-handed subjects. Post-intervention, there was significant intra-group improvements (p<0.05), but there were no significant inter-group differences (p>0.05).Conclusion: No significant benefits were seen in the balance of preschool children exposed to Brain Gym exercise.RCT registration: The RCT was registered retrospectively at The Pan African Clinical Trials Registry (PACTR) (Trial #: PACTR202208886771106 Date of Approval: 15/08/2022). Link: https://pactr.samrc.ac.za/Search.aspxKeywords: Leg, Exercise, Brain, Gym
Safe staple less laparoscopic splenectomy; use of Hem-o-Lok to control the splenic hilum
Authors: Sherif Mohammed Farahat  , Akram Elbatarny  , Khalid Mohamed. Elshimy  , Sherif Medhat  , Khalid Ahmed Ismail  , Mohamed Ahmed Arafa
Published: June 2023

Objective: To evaluate Hem-o-Lok polymer clips’ feasibility, safety and cost-effectiveness in controlling the splenic pedicle during paediatric laparoscopic splenectomy.Method: The prospective study was conducted from May 2019 to December 2021 at Kafrelsheikh University Hospital, Egypt, and comprised children of either gender aged <18 years who had benign haematological diseases and were indicated for laparoscopic splenectomy. During the procedure, Hem-o-Lok clips were used for controlling the splenic pedicle. Patients were encouraged to ambulate the same day, and the drain was removed 24hours postoperatively. The cases were followed up for three months postoperatively.Results: Of the 23 subjects, 11(47.8%) were boys and 12(52.2%) were girls. The overall mean age was 8.74±3.44 years (range: 4-15 years). There were 6(26%) cases of spherocytosis, 1(4.3%) immune thrombocytopenic purpura and 16(69.6%) with thalassemia major. The mean operative time was 93.43±29.87 minutes (range: 65-180 minutes). There was no conversion to open splenectomy and no mortality. There were 2(8.7%) cases of minor and 1(4.3%) of major intraoperative bleeding. All the 3(100%) cases were controlled laparoscopically. No postoperative bleeding occurred and no cases required postoperative blood transfusion.Conclusion: Controlling both the splenic artery and vein using Hem-o-Lok clips was found to be feasible, safe and cost-effective.Keywords: Purpura, Thrombocytopenic, Idiopathic, Spleen, Splenic artery, Thalassemia, Laparoscopy, Polymers.
Effect of educational programme on patients with bronchial asthma regarding self -care management
Authors: Eman Talaat Elshmaa  , Fatma Mostafa Mahrous  , Shimaa Nabil Abdelsalam  , Mayada Omar Elsadee
Published: June 2023

Objective: To evaluate the effect of educational programmes on patients with bronchial asthma regarding self-care management.Method: The quasi-experimental study was conducted at the El-Fayoum University Hospital, Egypt, from August 2021 to January 2022, and comprised patients of either gender aged >20 years who had a history of asthma attacks in the preceding 6 months. Data were collected through three questionnaires adapted from the literature regarding patients’ sociodemographic and clinical characteristics, their knowledge regarding asthma and self-care management, and their practices as noted through an observational checklist. After evaluation as a baseline, the subjects were given training through 30-minute sessions twice a week for a total of 10 sessions. They were also provided with a self-caremanagement booklet in the Arabic language. The post-intervention evaluation was at the end of the 10-session programme and then again 3 months after the first evaluation. The collected data were statistically analyzed using the statistical package for social science (SPSS) version (20), percentage (%), the arithmetic mean (), standard deviation (SD), and chi-square (X2 & p-value).Results: Of the 100 patients with a mean age of 31.5±7.41 years, 34(34%) were in the 30-40 years bracket, 63(63%) were males, 70(70%) could read and write, 94(94%) lived in urban areas, 50(50%) were smokers and 81(81%) said asthma attack was triggered by consumption of certain foods. At baseline, 69(69%) patients had unsatisfactory knowledge and 72(72%) had unsatisfactory practices regarding self-care management. Post-intervention, there was a highly significant improvement in knowledge and practice scores (p=0.001).Conclusion: The educational intervention improved patients’ knowledge, practice, and self-care management.Keywords: Asthma, Mortality, Ambulatory care, Self-care management.
Using machine learning models to investigate the relationship between corporeal workload and clinical and epidemiological features of patients infected with Covid-19 in Egypt
Authors: Ahmed Ali. Torad  , Fayiz El-Shamy  , Ahmed Mahmoud Tayee  , Zeinab Sami Ahmed
Published: June 2023

Objective: To explore if clinical and epidemiological features of patients positive for coronavirus disease-2019 are affected by somatic work stress.Method: The retrospective study was conducted at Kafrelsheik University Hospital, Egypt, and comprised data of patients admitted between April 1, to June 6, 2020, with confirmed coronavirus  disease-2019 infection. Health records of healthy subjects who had come to the hospital as part of their routine check-up were also included for comparison, and the researchers were blinded during the gathering and analysis phase. Demographic features, vital signs, infection severity, somatic workload of the patients’ jobs at admission, and detailed discharge profile was noted. The relationshipbetween clinical features and somatic work stress was evaluated. Data was analysed using SPSS 26.Results: Of the 1072 cases, 602(56.2%) were men and 470(43.8%) were women. The overall median age was 43 years (interquartile range: 29 years). The healthy group had 500 random subjects. There were significant differences in all vital signs between the patients and healthy controls (p<0.05). Among the patients, infection severity was higher in men, but it was not significant (p>0.05). The overall mortality was 69(6.4%); 46(4.3%) men and 23(2.2%) women. There was no significant association between gender and outcome (p>0.05). There were 816(76.11%) patients with lowintensity physical workload pre-infection, 136(12.68%) moderate and 120(11.19%) high. Infection severity was significantly high in the low-intensity group (p<0.05). However, the fate of the patients was not significantly associatedwith their pre-infection work profile (p>0.05).Conclusion: Coronavirus disease-2019 significantly affected patients’ vital signs, and infection severity was significantly associated with physical work stress. However, mortality and pre-infection somatic workload were not associated.Keywords: Sulphur dioxide, COVID-19, Epidemiologists, Healthy volunteers, Polymerase, Demography.
Effect of COVID 19 pandemic on the academic performance of physical therapy students
Authors: Ahmed Ali Mohammed Torad  , Omnia Ahmed  , Reham ElKalla
Published: June 2023

Objective: To examine the impact of university closure and recourse to internet-based learning on the academic achievement of physical therapy students.Method: The retrospective study was conducted at Kafrelsheikh University, Egypt, and comprised academic grades of physical therapy students related to pre-coronavirus disease-2019 pandemic academic year 2019-2020 in group 1 and per-pandemic 2020-2021 session group 2. Data was analysed using SPSS 26.Results: Of the 8,190 students, 4,764(58.2%) were females and 3,426(41.8%) were males with age range 17-23 years who were studying at 5 academic levels. There were 3,732(45.6%) students in group 1 and 4,458(54.4%) in group 2. There were significant difference in the academic grades between the groups (p<0.005). There was greater improvement in the mean results of students’ grades (p=0.001) and less variation between students in group 2 compared to group 1 (p<0.05).Conclusion: Online learning was found to be an effective teaching method for physical therapy students during the coronavirus disease-2019 pandemic with respect to basic medical knowledge. However, its impact on clinical and practical skills of the students was not confirmed.Keywords: COVID-19, Pandemic, Online learning, Student performance, Physical therapy.
Body mass index as a prognostic factor in HER-2 positive early breast cancer patients and its effect on duration of treatment with Trastuzumab: A retrospective study
Authors: Samaa AbdAlla Bardisi  , Amany Mostafa ElFeky  , Eman Ismail Ibrahim  , Yousra Dorgham  , Emad Abd Elmongy Sadaka
Published: June 2023

N/A
Correlation between antimicrobial resistance and virulence genes in Klebsiella pneumoniae isolates from Egypt
Authors: Nasma Maged Elemary  , Mohamed Mahrous Emara  , Amin Abd Elhady Tahoun  , Ramadan Ahmed Eloomany
Published: June 2023

Objective: To genotypically assess the relationship between certain resistance and virulence determinants.Method: The cross-sectional study was conducted at Kafrelsheikh University, Egypt, from March 2019 to May 2021, and comprised pathological samples, like blood, sputum, urine, vaginal swabs and wound swabs, that had been taken from patients who had never received treatment. The sample were collected from Kafrelsheikh and Mansoura University hospitals, and Klebsiella pneumoniae isolates were obtained. Resistance and virulence determinants were tested phenotypically. Uniplex polymerase chain reaction was used to evaluate the presence of several resistanceaccompanied genes and virulence genes in the isolates. Disc diffusion method was used to assess the isolates’ susceptibility in accordance with the Clinical and Laboratory Standards Institute criteria for identifying diverseresistance patterns.Results: There were 23 isolates from 16 patients. Of the tested isolates, 22(95.65%) showed drug resistance; 19(82.6%) had multidrug resistance, and 3(13.04%) had extensive drug resistance. There was no case of pan drug resistance. CTX-M-15, NDM, CTX-M-1, VIM-1 and qnr B genes were detected in 14(60.86%), 13(56.5%), 6(26.08%), 6(26.08%) and 6(26.08%) isolates, respectively. Moreover, 6(26.08%) isolates exhibited extended-spectrum beta-lactamase producers, and 12(52.17%) of such isolates contained both CTX-M-1 and CTX-M-15 genes, 6 and 33.3% contained CTX-M-1, CTXM- 15 and fox genes. Type 3 fimbriae adhesin mrkD and mucoviscosity regulatory gene uge were found in the testedisolates. However, gene of iron uptake system kfu was found in 8(34.78%) isolates, and increased serum survival protein is and mucoviscosity accompanied gene magA were detected in 3(13.04%) isolates. A direct correlation was found among 5 from 8 Klebsiella pneumoniae virulence genes and antimicrobial resistance genes.Conclusion: There was a direct correlation between the existence of virulence factors and resistance to antimicrobials.Keywords: Lactamase, Klebsiella pneumoniae, Anti-bacterial, Virulence, Bacterial, Genes.
Coronary plaque morphology and characteristics in patients with raised haemoglobin A1c: an intravascular ultrasound Study
Authors: Ahmed Mostafa Ahmed  , Wael Anwar Haseeb  , Reda Biomy Bastawisy  , Mohammed Kamal Salama
Published: June 2023

Objectives:To identify coronary plaque morphology using grey scale and virtual histology intravascular ultrasound in patients with and without elevated glycated haemoglobin.Methods: The cross-sectional study was conducted at the Cardiology Department of Kafrelsheikh University, Egypt, from November 2019 to January 2022, and comprised adult patients of either gender suffering from acute coronary syndrome admitted for catheterisation. The patients were divided into three groups.Diabetic patients were in group A, prediabetic patients with elevated glycated haemoglobin in group B, and patients with normal glycated haemoglobin in group C. All patients were subjected to clinical examination, 12-lead electrocardiogram, coronary angiography and multimodality intravascular ultrasonography scan of proximal segments 3-6cmof non-culprit coronary arteries intra group differences were compared using the analysis of variance (ANOVA) test.Continue..
Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study
Authors: Asmaa Saeed Bayan  , Nahla Abd El-Aziz Nosair  , Abeer Mohamed Salamah
Published: June 2023

Objectives: To estimate vitamin D levels in children with type 1 diabetes, and to evaluate its role in the pathogenesis and progress of the disease.Method: The cross-sectional study was conducted at the Paediatric Department of Kafrelsheikh University Hospital, Egypt, from November 2019 to August 2021, and comprised children of either gender aged 3-18 years who were either inpatients or visiting the paediatric outpatient clinic. The subjects were enrolled into 3 groups. Those with newly diagnosed type 1 diabetes were in group A, those with established type 1 diabetes were in group B, and healthy children matched for age and gender and randomly selected were in the control group C. Glycated haemoglobin, serum fasting C-peptide, and serum vitamin D levels were evaluated using quantitative colorimetric determination,an automated analyser, and enzyme-linked immunosorbent assay, respectively. Data was analysed using SPSS 25.Results: Of the 80 subjects, 30(37.5%) were in group A; 17(56.7%) boys and 13(43.3%) girls with mean age 7.77±2.95 years. In group B, there were 30(37.5%) subjects; 14(46.7%) boys and 16(53.3%) girls with mean age 9.6±3.62 years. There were 20(25%) subjects in group C; 10(50%) boys and as many girls with mean age 8.38±2.68 years (p>0.05). Glycated haemoglobin, serum fasting C-peptide and serum vitamin D was significantly different between the control group and the treatment groups (p<0.05). Between the treatment groups, group B had better markers than group A (p<0.05).Conclusion: Serum vitamin D deficiency may play a role in the pathogenesis and insulin sensitivity in cases of type 1 diabetes.Keywords: Diabetes mellitus, C-Peptide, Glycated haemoglobin, Colorimetry
Case report of rib polyostotic fibrous dysplasia
Authors: Mohamed Magdy Abd Elalim  , Amr Abdou Ettish  , Wael Mohamed Elfeky  , Mohamed Moustafa Abdelaal
Published: June 2023

Polyostotic fibrous dysplasia is a rare benign asymptomatic tumour of the ribs not requiring surgery on most occasions. We present here a case with left 10th and 11th rib fibrous dysplasia which was causing a hinderance to the Urologist for renal stone extraction. Therefore the 10th and 11th ribswere excised followed by chest wall reconstruction.
Keywords: Fibrous dysplasia, polyostotic, thoracic wall, ribs, neoplasms
Tissue Inhibitor of Metalloproteinase 3 as a potential staging biomarker in hepatocellular carcinoma
Authors: Nabil Mohie  , Shimaa Ali Abass Mohammad  , Ramadan Ahmed Eldomany  , Sherin Zakaria
Published: June 2023

Objective: To assess the potential role of tissue inhibitor of metalloproteinase 3 as a staging marker of hepatocellular carcinoma.Method: The experimental study was conducted at Faculty of Pharmacy, Kafrelsheikh University, Egypt, from December 2020 to March 2022 after approval from the Faculty of Pharmacy, Kafrelsheikh University, Egypt, and comprised male albino rats. The subjects were divided into 4 groups. The control group was administrated a single intraperitoneal injection of normal saline, while the other groups were generated post-induction of hepatocellular carcinoma. The induction was done by injecting rats intraperitoneally with a single dose of 200mg/kg diethyl nitrosamine, followed by the administration of 0.05% phenobarbital sodium in drinking water daily. Rats were euthanised at 8, 16 and 24 weeks after the injection to obtain three groups related to the 3 stages of hepatocellular carcinoma. Serum was used for measuring the alpha protein level. Liver homogenates were used for the assessmentof the hepatic tissue inhibitor of metalloproteinase 3 expression, B-cell lymphoma 2-associated X protein expression, and the hepatic content of matrix metalloproteinase -9 and cyclin D1. Data was analysed using Graph Prism 8.Results: Of the 24 rats with weight range 120-130g, 6(25%) were in each of the 4 groups. The relative protein and messenger ribonucleic acid tissue inhibitor of metalloproteinase 3 expressions were significantly decreased in the intervention groups compared to the control group, with more decline as the hepatocellular carcinoma stage increased. The matrix metalloproteinase -9 and cyclin D1 concentrations and the relative hepatic protein Ki67 expression were significantly raised in the intervention groups compared to the control group (p<0.05). The relative expression of hepatic B-cell lymphoma 2-associated X protein was markedly decreased in the intervention groupscompared to the control group (p<0.05).Conclusion: Tissue inhibitor of metalloproteinase 3 might be a promising diagnostic and staging biomarker in hepatocellular carcinoma.Keywords: Carcinoma, Hepatocellular, Neoplasms, Fetoproteins, Metalloproteinase, Cyclin, Antigen, Phenobarbital, Nitrosamines.
Hubungan Tahap Aktiviti Fizikal dan Keseronokan Murid Sekolah Rendah dalam Pendidikan Jasmani
Authors: Kamarudin Nurul Akasyah , Amran Syawal
Published: June 2023

Kajian ini bertujuan untuk mengkaji tahap aktiviti fizikal dan tahap keseronokan kanak-kanak terhadap kesan penutupan sekolah. Soal Selidik digunakan dalam kajian tinjauan ini sebagai instrumen untuk pengumpulan data. Seramai 123 responden daripada beberapa buah sekolah sekitar Pulau Pinang terlibat dalam kajian tinjauan ini. Tahap aktiviti fizikal diukur dengan instrumen soal selidik Physical Activity for Children Questionnaire (PAQ-C) manakala tahap keseronokan diukur menggunakan instrumen soal selidik Physical Activiti Enjoyment Scales (PACES). Perisian SPSS 26.0 digunakan untuk menganalisis data yang dikumpulkan untuk menilai tahap aktiviti fizikal dan keseronokan dan juga mengkaji hubungan keduanya. Dapatan kajian mendapati tahap aktiviti fizikal dan keseronokan murid semasa pandemik berada pada tahap sederhana (min = 2.37) manakala tahap aktiviti fizikal dan keseronokan murid selepas pandemik juga berada pada tahap sederhana (min = 3.08). Hubungan antara kedua pemboleh ubah ini iaitu r = 0.45, mempunyai kekuatan yang sederhana. Hasil kajian ini diharap akan membantu para guru mengetahui tahap aktiviti fizikal dan keseronokan murid dan guru dapat merangka aktiviti yang bersesuaian dalam mata pelajaran Pendidikan Jasmani serta pengkaji lain juga dapat menjalankan kajian yang baru.
The Impact of Artificial Intelligence on Business Processes
Authors: Bharadiya Jasmin
Published: June 2023

Purpose: The purpose of the study is to examine the challenges faced by businesses in integrating and effectively utilizing artificial intelligence (AI) technology. It aims to provide a comprehensive understanding of how AI technologies generate business value and the anticipated benefits they offer. The study also seeks to identify the facilitators and inhibitors of AI adoption and usage, explore different types of AI use in the organizational environment, and analyze their first- and second-order impacts.

Methodology: The study employed the comprehensive literature review research design. The researchers conducted a systematic search using predefined criteria in databases such as Scopus and Web of Science. The search yielded 21 relevant papers that were analyzed and synthesized for this study. The data collection method relied on the examination of existing literature. Data analysis involved identifying key themes, trends, and insights from the selected papers. The researchers conducted a qualitative analysis to extract relevant findings and synthesized the information to derive meaningful conclusions.

Findings: The study revealed several insights regarding the integration and use of AI in businesses. This indicated that organizations struggle with understanding how AI technologies can generate value and how to effectively incorporate them into their operations. Lack of comprehensive knowledge about AI and its value generation processes was identified as a major barrier. Additionally, the study highlighted the facilitators and inhibitors of AI adoption and usage. It identified various types of AI applications in the organizational environment and explored their impacts on business operations. The findings shed light on the challenges businesses face in leveraging AI technology and suggested areas for further research.

Recommendations: To practitioners: The study emphasizes the importance of acquiring comprehensive knowledge about AI technologies and their potential value generation processes. To policy makers: The study highlights the need for supportive policies and regulations to foster AI adoption. It suggests creating an enabling environment that promotes AI research and development. Theory and Validation: The study may have been informed by existing theories related to AI adoption, organizational change, or innovation. Practice: To practitioners, the study underscores the importance of understanding the value and potential of AI technologies. Policy: To policy makers, the study emphasizes the need for policy frameworks that promote AI adoption and address associated challenges.
Pengaruh Pengungkapan Tanggung Jawab Sosial Terhadap Penghindaran Pajak dan Peran Asuransi
Authors: Santoso Eko Budi
Published: June 2023

Corporate Social Responsibility (CSR) has been raised as firms strategic issue in developing countries such as Indonesia. Although the disclosure of social responsibility is still voluntary, many firms are starting to publicize their CSR activities and even provide assurance to get appreciation as socially responsible firms. However, several socially responsible firms have been engaged in tax scandals, raising questions of whether CSR disclosure is used to hide firm fraud or as a reflection of a real socially responsible firm. This study investigates the effect of CSR disclosure and tax avoidance and the role of sustainability reporting assurance to that association. Using Indonesian go public firms published CSR report as a sample, the empirical result shows that CSR disclosure positively effect tax avoidance. Furthermore, results also indicate sustainability reporting assurance moderates the association. The findings indicate that stakeholders should carefully examine firms with active CSR disclosure before labeling it as socially responsible firms.
Pengaruh Lingkungan Kerja, Fasilitas Kerja dan Beban Kerja Terhadap Kinerja Karyawan pada PT. Lembah Karet Padang
Authors: Henryanto Abaharis  , Suchi Dwinanda
Published: June 2023

The purpose of this study was to examine the effect of work environment variables on employee performance at PT. Padang Rubber Valley. to test the effect of work facility variables on employee performance at PT. Lembah Karet Padang, to test the effect of workload variables on employee performance at PT. Padang Rubber Valley. Collecting data by distributing questionnaires to 75 respondents, by using test instrument test (validity test and reliability test), descriptive analysis, classic assumption test (normality test, multicollinearity test and heteroscedasticity test) multiple linear regression and t test, with the help of the SPSS application. The results of the study show that the work environment has a positive and significant effect on employee performance at PT. Lembah Karet Padang, work facilities have a positive and significant effect on employee performance employee performance at PT. Lembah Karet Padang, workload has a positive and significant effect on employee performance employee performance at PT. Lembah Karet Padang, which means that the first hypothesis is accepted and the second hypothesis is accepted and the third hypothesis is accepted.