bluuebunny/crossref_metadata_2025 huggingface dataset:
Xây dựng quy trình realtime RT-PCR phát hiện Zika và Chikungunya
Authors: Quyên Đào Thanh , Trung Ngô Tất , Sỹ Bùi Tiến , Trang Trần Thị Huyền , Giang Đào Phương , Hiền Trần Thị Thu , Tĩnh Nguyễn Thị , Hà Trần Thái , Hà Nguyễn Việt , Anh Trần Đức , Hường Hồ Thị , Hoàn Phan Quốc
Published: June 2022

Mục tiêu: Xây dựng quy trình realtime RT-PCR phát hiện Zika (ZIKV) và Chikungunya (CHIKV). Đối tượng và phương pháp: Mẫu chứng dương ZIKV do NIHE, CHIKV do Tổ chức Y tế Thế giới (WHO) cung cấp và các virus khác được sử dụng trong nghiên cứu này. Để đánh giá ngưỡng phát hiện, độ nhạy kỹ thuật realtime RT-PCR, nghiên cứu sử dụng mẫu RNA chứng dương pha loãng từ 105÷100 copies/µl. Mồi và probe được thiết kế dựa trên trình tự tham chiếu trên ngân hàng gen. Độ đặc hiệu của phương pháp được đánh giá dựa trên khả năng không bắt chéo với các virus khác. Một phản ứng khuếch đại nội chuẩn để đánh giá hiệu quả tách chiết và hiệu suất khuếch đại của phản ứng realtime RT-PCR. Kết quả: Ngưỡng phát hiện ZIKV và CHIKV tương ứng 5 và 3 copies/µl tương đương 500 và 300 copies/ml. Độ nhạy và độ đặc hiệu tương ứng 95%, 100%. Kết luận: Đã thiết lập thành công quy trình realtime RT-PCR phát hiện virus Zika và Chikungunya với độ nhạy, độ đặc hiệu kỹ thuật cao.
Tầm soát biến cố tăng kali máu liên quan đến thuốc thông qua kết quả xét nghiệm cận lâm sàng tại Bệnh viện Trung ương Quân đội 108
Authors: Trung Nguyễn Đức , Yến Nguyễn Thị Hải , Yến Nguyễn Thị Hải , Thủy Nguyễn Thị Thu , Mỹ Lê Thị , Trường Nguyễn Hải
Published: June 2022

Mục tiêu: Nhằm phát hiện biến cố tăng kali máu trên bệnh nhân nội trú dựa vào cơ sở sữ liệu xét nghiệm và để mô tả đặc điểm các trường hợp tăng kali máu liên quan đến thuốc được xác định theo thang đánh giá nhân quả của WHO - UCM. Đối tượng và phương pháp: Tất cả xác xét nghiệm kali máu của bệnh nhân nội trú tại Bệnh viện Trung ương Quân đội 108 năm 2019; Phương pháp: Hồi cứu, mô tả cắt ngang. Thông tin được thu thập từ hồ sơ bệnh án của từng bệnh nhân. Nghiên cứu loại trừ các trường hợp tăng kali máu giả và những bệnh nhân chạy thận nhân tạo. Kết quả: có 136 trường hợp tăng kali máu (tuổi trung bình 65,8 ± 17,6 năm), có 76 trường hợp (55,9%) được xác định là tăng kali máu có liên quan đến thuốc. Sự suy giảm chức năng thận (eGFR < 60mL/phút/1,73m2) được phát hiện trong hầu hết các trường hợp (89,7%). Hầu hết các bệnh nhân có mức độ tăng kali máu mức độ nhẹ (52,2%) trong khi bệnh nhân tăng kali máu mức độ nghiêm trọng và nguy hiểm đến tính mạng xảy ra với tỷ lệ 24,2%. Các thuốc điều trị loét dạ dày - tá tràng, thuốc đối kháng aldosteron và các chất bổ sung kali là nhóm thuốc chủ yếu gây tăng kali máu. 88,2% bệnh nhân được điều trị tình trạng tăng kali máu, chủ yếu là với furosemid và canxi clorid. Kết luận: Kết quả của nghiên cứu này cho thấy sự cần thiết phải theo dõi thường xuyên nồng độ kali máu của bệnh nhân được điều trị bằng các thuốc có nguy cơ gây tăng kali máu.
Chronic myeloid leukemia management during pregnancy: a case report
Authors: Lima Luina Benevides , Moreira-Nunes Caroline de Fátima Aquino , Mesquita Felipe Pantoja , De Oliveira Lais Lacerda Brasil , Bezerra Emanuel Cintra Austregésilo , Da Silva Emerson Lucena , Duarte Fernando Barroso , Quixadá Acy Telles de Souza , De Moraes Maria Elisabete Amaral , Montenegro Raquel Carvalho
Published: June 2022

Chronic Myeloid Leukemia (CML) is characterized by the increased and unregulated growth of myeloid cells in bone marrow and accumulation of these cells in blood. Its occurrence during pregnancy is a very rare condition and the correct management is not well stablished yet. We present a case of a 21-year-old female diagnosed with CML during pregnancy. The protocol chose by the doctor was hydroxyurea on second trimester, and interferon-alpha on third trimester. The baby was born healthy and at the expected time. After giving birth, the patient started Imatinib Mesilate (IM) 400mg/day treatment and was able to control the disease.
In silico Analysis of Flavanones capable of inhibiting covid19 RNA dependent RNA polymerase
Authors: G. Kowsalya , S. Shanmugasundaram
Published: June 2022

Virtual screening of flavanone against RdRp of SARS-CoV-2 was carried out using AutoDock Vina and ligPlot. Out of 16 compounds screened, Eriodictyol, Naringin, Hesperidin Methylchalcone were found to have good affinity values for binding. While Eriodictyol binds to amino acids, R836, K849, R858, Naringin binds to S814, R836, R858 and Hesperidin Methylchalcone binds to amino acids D760, S814, R836 amino acids are present in RdRp of covid19. Since these amino acids bind to the primer RNA, binding of flavanones to these amino acids could destabilize the replication complex and may inhibit viral RNA replication. All the compounds pass ADMET test indicating their drug potential.
Synthesis of Ethyl 2-(4-halobenzyl)-3-oxobutanoate and determination of its Biological activity by using prediction of activity spectra for substance
Authors: R. Chandramore Kavita , S. Ahire Rohan
Published: June 2022

In this study, Synthesis of ethyl 2-(4-halobenzyl)-3-oxobutanoate was carried out by using addition of substituted benzyl bromide to a suspension of t-BuOK (Potassium tert-butoxide) in THF (tetrahydrofuran). The reaction mixture was then refluxed for 12 hr. The progress of reaction was monitored using thin layer chromatography (TLC). Synthesize compound are characterized by elemental analysis and spectral analysis like infra red spectroscopy, nuclear magnetic spectroscopy and mass spectroscopy (IR,1H-NMR, MS). Pharmacological activity of these compound were predicted by individually using prediction of activity spectra for substance (PASS). It shows various pharmacological activities and mechanism of action such as L-glucuronate reductase inhibitor, Gluconate 2-dehydrogenase (acceptor) inhibitor, Centromere associated protein inhibitor, Eye irritation, inactive, GST A substrate, Pectate lyase inhibitor, 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase inhibitor, Acetylcholine neuromuscular blocking agent, Antihypoxic, Aspulvinone dimethylallyl transferase inhibitor.
Influence of Newly Synthesized Superdisintegrant on Dissolution Rate Enhancement of Carbamazepine using Liquisolid Compact Technique
Authors: G. Raut Vrushali , P. Chaudhari Bharatee , K. Redasani Vivekkumar
Published: June 2022

The purpose of this study was to manufacture liquisolid compact of high dose poorly water-insoluble drug, Carbamazepine (CBZ) by using novel superdisintegrant for the purpose of fast disintegration and improved its dissolution rate. The solubility of CBZ was analyzed in various non-volatile solvents in order to find the vehicle with the maximum solubility. The dissolving profile of liquisolid compacts was compared to a marketed tablet formulation's dissolution profile. CBZ was found to be much more soluble in polyethylene glycol 200 than in the other solvents. Crosspovidone-containing formulations showed no disintegration, but all other formulations disintegrated after 91.2 seconds. A Starch Glutamate-Croscarmellose Sodium combination has a disintegration time of 42.5 seconds. The optimized batch NSC1 including Starch Glutamate-Croscarmellose Sodium had 94.81 % greater drug release compared to the marketed formulation. This investigation found that the novel superdisintegrant had the fastest disintegration and the highest drug release compared to other disintegrants.
Formulation and Evaluation of Buccal Disintegrating Tablet of Anticonvulsant Drug
Authors: M. Akotakar Akshay. , A. Zanke Ashwini. , B. Ghonge Ananta.
Published: June 2022

Oral and Buccal delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. To troubleshoot such problems a new dosage form known as Buccal and orally disintegrating tablet, has been developed which rapidly disintegrate and dissolve in saliva and then easily swallowed without need of water which is a major benefit over than conventional dosage form. In addition, patients suffering from dysphasia, motion sickness, repeated emesis and mental disorders prefer such preparation because they cannot swallow large quantity of water. the immediate release of medication and for instant release at desire location in which the drug is absorbed distributer and easily metabolized. e.g. To prepare and characterize buccal tablets of Gabapentin using different super disintegrants such as Cross povidon, PVP K30, Micro crystalline cellulose. This types of formulation of improving solubility of drug and development of Buccal drug delivery system.
Review on Microwave Application in Petroleum processing
Authors: G. Dhakad Ganesh. , V. Patil Rohit. , I. Chaudhari Tejas. , D. Ahire Rajesh. , S. Jain Ritik.
Published: June 2022

Microwave energy is becoming the most diverse form of energy transfer, used in the petroleum industry for inspecting coiled tubing and line Pipe, measuring multiphase flow, and the mobilization of asphaltic crude oil. Depletion of conventional crude oil reserves creates economic Demand for various fuels; in Canada, efforts have intensified to develop microwave technology for in-situ enhanced oil recovery of heavy oil/Bitumen; about 26 of the estimated 30 billion barrels of heavy oil are considered unrecoverable using current technology. Specific objectives included Studying microwave process conditions affecting upgrading of heavy oil/bitumen to synthetic crude and achieve up to 50% desulphurization. This review provides a general overview of microwave applications in oil sands bitumen or shale oil pro-Duction in petroleum upgrading. The vast oil reserves in the oil sands of Alberta will become a major source of petroleum products in the near future and a number of alternative technologies have been explored for the production and upgrading of oil sands and heavy oil.
Chemical Composition of Clerodendrum Phlomidis: A Review
Authors: Chowdhary Yogita
Published: June 2022

Agnimantha is a medicinal plant that grows either as a large shrub or a small tree. Its height is up to 10 meters tall. Its bark, roots, and leaves are used for medicinal purposes. In Agnimantha, ‘agni’ means fire, ‘mantha’ refers to churning. In the English language, Agnimantha is referred to as a headache tree. As per Ayurveda, agnimantha is an important ingredient of Dashmool Plants. Dashmool has two subcategories Brihat Panchamoola and Laghu Panchamoola and in these subcategories, Agnimantha is included under Brihat Panchamoola. As per Ayurveda, Agnimantha is useful in treating all types of Vata Disorders (that related to the nervous and musculoskeletal system), inflammatory disorders, neuralgia, rheumatoid arthritis, anemia, piles, constipation, common cold. Roots of agnimantha have the property of appetizer and digestive. It boosts the appetite and aids in the proper digestion of food. It can digest foods, treats heaviness in the abdomen, drowsy, or tiredness after having a meal. It reduces all the symptoms related to digestion and promotes proper assimilation of the food. Agnimantha leaves boost up the metabolism of the body. These have anti-obesity effects and the juice extracted from its fresh leaves is very helpful for reducing weight and improves the metabolism of the fats and prevents fat accumulation. These should be taken twice daily for at least 3 months for better results. Roots of agnimantha are especially used in the treatment of urticaria because it has anti-allergic, anti-urticaria action, which helps to reduce prickling pain, hives, and itching. Being an anti-inflammatory, antibacterial and antiviral action helps to inhibit the growth of microbes, fights against infections, and reduces inflammation.
Pharmacological Review on Tobramycin
Authors: Jodh Rahul , Tawar Mukund , Kachewar Aparna , Ingole Yogiraj , Deshmukh Tejas , Ijapure Vipul
Published: June 2022

Tobramycin is another aminoglycoside anti-microbial with a wide antibacterial range in vitro, and pharmacokinetic properties like those for gentamicin. Tobramycin is more dynamic than gentamicin against Pseudomonas aeruginosa and dynamic against numerous gentamicin safe strains, yet isn't dynamic against enterobacteriaceae impervious to gentamicin. Hypothetically, tobramycin enjoys an upper hand over gentamicin against diseases brought about by P. aeruginosa, yet any benefit in clinical practice presently can't seem to be enough illustrated. Clinical involvement in tobramycin is significantly not exactly with gentamicin. While tobramycin seems to offer no unmistakable benefits over gentamicin against touchy organic entities it is shown in contamination brought about by strains of P. aeruginosa which are impervious to gentamicin, yet touchy to tobramycin. Like gentamicin, tobramycin acts synergistically with carbenicillin and the cephalosporins. The viability of the tobramycin-carbenicillin blend has been displayed in endocarditis brought about by P. aeruginosa which was lethargic to gentamicin in addition to carbenicillin. Ototoxicity and nephrotoxicity like that seen with other aminoglycosides have been experienced in helpful preliminaries with tobramycin and more extensive clinical experience is important to decide the general occurrence of these incidental effects with gentamicin and tobramycin utilized under comparable conditions. Antimicrobial movement: In relative examinations, in vitro, tobramycin is more dynamic than gentamicin against clinical separates of Pseudomonas aeruginosa. Likewise, the inhibitory file, which is the proportion between the serum fixations accomplished at common remedial portions and the base inhibitory focus, for Pseudomonas aeruginosa is higher for tobramycin than for gentamicin.
A Review on Variant of Concern (Delta Variant of COVID 19)
Authors: Jangam K. K. , Vikhe D. N. , Jadhav R. S. , Shinde G. S.
Published: June 2022

The B.1.6179 Delta variant of the severe acute metabolic process syndrome corona virus (SARS –COV-2). The virus that causes corona virus unwellness 2019 (covid -19), has contributed to a surge in cases of Republic of India and has currently been detected across the world, as well as a notable increase in cases within the UK. Delta and (B.167.2.1/(Ay.1) could be a new variant of the SARS- CoV-2. corona virus came in existence because of a mutation within the delta strain of the virus (B.1.617.2 variant). It is technically successive generation of SARS-COV-2. This mutant of delta was initial detected in Europe march 2021.The delta virus that was initial detected in Republic of India (in February 2021) eventually became an enormous downside for the total world. However, the delta variant at the moment, is restricted to smaller areas within the country. Individual’s reportable symptoms like headaches, sore throats, fluid noses, and fever. The world health organization (WHO)is following this variant as a part of the delta variant as well as for different variants of concern with extra mutations. This review provides detail idea about delta virus its treatment, prevention and methods for reduction of sensitivity.
Preparation and Evaluation of Sustained Release Microbeads Containing Ibuprofen
Authors: Hakam Nawaz , Vyawahare Aman , Patharkar Swanand , Gajbhiye Kalpak
Published: June 2022

The current study was carried out in order to prepare sustain release multiparticulate drug delivery system of Ibuprofen which is also known as 2-(4-isobutylphenyl) propionic acid. From the drug excipient study it was found that the drug and polymer were compatible with each other and there was no disappearance, new formation of peaks on the FTIR study. From the DSC study it was seen that there was no change in the melting point of drug when mixed with the polymers. The method applied was Ionotropic gelation. The Microbeads were prepared by employing sodium alginate as a coating agent with HPMC as release retardant and calcium chloride as a cross linking agent. The prepared microbeads were evaluated for various parameters such as micromertics, loose surface crystal study, percentage yield, percent cumulative drug release and surface morphology. From the various evaluated parameters it was revealed that the prepared microbeads were having a good flow property. The percentage yield was found to be in the range of 65.23% - 79.45%, the drug release was found to be in the range of 4.96% - 96.08%. The batch of B7 was the optimized one as it contain higher amount of drug content and shows better amount of drug release then the other batches. The surface morphology study revealed that the optimized formulation was having small cracks or fractures on the surface. From the study we can conclude that this method can be employed for preparing microbeads of Ibuprofen without any difficulty and this formulation can utilized for reducing the dose frequency of Ibuprofen which will not hinder the GIT.
Formulation and Evaluation of Transdermal Patches of Selegiline
Authors: Jacob Liji , Salim S Manju , Saju Jilby
Published: June 2022

Selegiline is an antiparkinsonian drug. It is a MAO-B enzyme inhibitor. It undergoes hepatic first pass metabolism and it result in 10% bioavailability on oral administration. So it was designed to formulate transdermal patches of Selegiline HCl for enhancing the bioavailability and patient compliance. Different formulation were prepared by different grades and varying concentration of polymer by solvent casting method. PG was used as permeation enhancer. The films were subjected to evaluation parameters like weight variation, thickness, moisture content, tensile strength, folding endurance, drug content and in-vitro drug release.
Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method
Authors: Vasavi Ayanam , Mrunalini Miriyala , Vasanthi Ayanam , Babu G. Raveendra , M. Sowjanya
Published: June 2022

As a novel drug delivery system, microspheres improve the efficacy of a drug, increase the time of action, lower the number of times in which a dosage form needs to be administered, and to increase patient compliance. Oral administration side effects such as gastric irritation are lessened through the use of microspheres. Ionotropic gelation was used to create HPMC K15M, Guar gum, and Carbopol 934 microspheres with different concentrations of Carbopol 934 polymer. Cross-linking was accomplished with the use of calcium chloride. In order to conduct a systematic evaluation of all the preparations, we performed various tests: morphology, FTIR, DSC, entrapment efficiency, size, microsphere size, and in-vitro drug release. The discrete, free-flowing, and spherical particles of prepared Stavudine microspheres were found. In compliance with standards, the mean particle size was in the range of 72.64 to 95.22 percent. In vitro drug release studies were performed in phosphate buffer solution with a pH of 6.8. As the concentration of sodium alginate and calcium chloride increased, the percentage of drug release was reduced. In the case of F9 formulation, which contained Stavudine, the decreased drug release rate was obtained via carbopol 934(1:3), sodium alginate, and calcium chloride. Conclusively, the present study shows that Stavudine microsphere preparation and formulation F9 are successful. Stavudine microspheres must be prepared in order to preserve an effective drug concentration in serum for a long time, while reducing gastrointestinal irritation.
Insight on Development and Evaluation of Nanosponge Drug Delivery for improved Therapeutic effectiveness
Authors: Potdar Sandhya , Ingale Vidyaranee , Kulkarni Nilesh , Munde Manojkumar , Dhole Shashikant
Published: June 2022

Nanosponges are the recent advances in nanotechnology. Nanosponge delivery system was originally developed for topical drug delivery. Nowadays it can also be used for oral delivery of drugs using water soluble and bio erodible polymers. Nanosponges are porous structures with a size of about a virus (average diameter below 1µm). Due to small size and porous nature; nanosponges can bind to poorly soluble drugs and improves their bioavailability. These nanosponges can circulate within body and interact with specific target site. At target site start releasing the drug in a controlled manner. Various techniques are reported for the preparation of Nanosponges as melt method, solvent diffusion method, solvent method, ultrasound assisted method and sonication etc. Nanosponges are the target specific drug delivery which has lesser side effects. Major advantage of nanosponges as it improves solubility of poorly soluble drug and exhibits higher drug loading as compared to other nanocarriers. This review gives the highlights about the formulation methods, excipients used, evaluation of nanosponges and its benefits to overcome the undesirable properties of drug into desirable.
A Comprehensive Review on Microspheres
Authors: Ahmad Wajid , Quazi Jaza , Khan Reshma , Ahmad Nadeem , Ansari Nawed
Published: June 2022

Microspheres are typically free flow powders consisting of proteins or synthetic polymers which are biodegradable in nature. And ideally having a particle size less than 200μm. Microsphere after ball bearing effects because of their spherical shape. The therapeutic efficacy of microspheres contain drug depends upon their characteristics that can be altered in required terms by altering materials, methods, polymers or techniques used. A Microspheres has its drug dispersed throughout the particle i.e. the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs to the tumor. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.
The Wonder of Herbs to Treat – Alopecia
Authors: Jaunjal Pooja , Katolkar Parimal
Published: June 2022

Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Hair loss problem is of great significance to both men and women. Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetics, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs. Herbs are starting material for any medicine research. Approximately about 80% residents recommended herbal drugs for their beneficial effects along with fewer side effects as compared synthetic drugs.
An updated review on current situation of Corona virus disease
Authors: Mali Sunayana , Mali Audumbar , Patil Manojkumar , Bathe Ritesh , Bathe Dipak
Published: June 2022

COVID-19 is currently regarded as a lethal disease. COVID-19 has exaggerated over 2.5 million citizen’s universal, consequential into more than 170,000 confirmed cases deaths Very recently a novel corona virus, SARS-CoV-2, was identified because of causal cause of an outbreak of viral pneumonia centered around Wuhan, Hubei, China in Dec 2019, now called as COVID-19. The corona disease infection 2019 (Covid-19) (2019-nCoV) pandemic is an international public health emergency with major social and economic disruptions and devastating health consequences. COVID-19 is also known as a pandemic. COVID-19 has infected over 2.5 million people around the world, resulting in over 170,000 deaths. The rapid development of vaccines is imperative. Corona viruses are a group of related RNA viruses that cause diseases in mammals and birds. It triggers breathing zones that can vary from moderate to fatal in humans and birds more than a few issues to ordinary frosty (so as to can also be affected via different pathogens, mostly rhinoviruses) are mild, while more deadly strains be able to reason SARS, MERS, and COVID-19 in humans. Thousands of illnesses and deaths have occurred as a result of the disease. In fact, none exact cure remains available for the disorder yet this demands that even the condition should not expand. Notable Isolation of sick people, adequate ventilation, hand washing, and the utilization of PPE Kit are also preventive measures. As a result, this paper covers all aspects of COVID-19, including epidemiology, transmission, clinical characteristics, diagnosis, treatment, and prevention.
Review Article on Enteric Coated Tablets
Authors: K. Joshi Ketki , S. Jain Ritik
Published: June 2022

In these article we have discuss, enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to smaller size than tablets b) Pellets exhibits less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resisitance time in the stomach. We also discuss, Advantage and disadvantages tablet coating and mechanism of enteric coated tablet.
Review on development of Analytical Method and Validation by Reverse Phase – High Performance Liquid Chromatography
Authors: Jumde H. S. , Mankar S. D.
Published: June 2022

RP-HPLC is the most, sensitive, universal analytical procedure. It is extremely versatile tech where analytes are separated by passes through column of different sized particles. Analytical method development ensures the specific characteristics of the drug substances against the preconceived acceptance criteria, while method meets objectives required at each stage of development of drug which is a continuous process, and should be robust and accessible. Validation of analytical method demonstrates the scientific firmness of measurement or characterization and is required throughout the regulatory submission process and the main purpose of validation of API is to demonstrate that it maintains the desired level of compliance and also suitable for its intended purpose.
Fast Dissolving Tablets: A Review
Authors: I. Madhumathi , B. Hemalatha , K. Padmalatha
Published: June 2022

In the pharmaceutical Industry oral route is considered as the safest and convenient route. Fast dissolving tablets (FDTs) are solid dosage forms containing drugs that disintegrate in the oral cavity within less than 1 minute leaving an easy to swallow residue. These dosage forms include superdisintegrants which impart quick disintegration with existence of saliva and can be swallowed without difficulty. Fast dissolving tablets are the very good preference for the paediatric as well as geriatric patients. To improve the bioavailability of many drugs, fast dissolving drug delivery systems are used widely. Sophisticated technologies used for manufacturing fast dissolving tablets are by direct compression method, freeze drying method, sublimation method, mass extrusion and cotton candy process. Taste is the vital factor since these tablets disintegrate directly in the mouth. FDTs are evaluated by various parameters such as hardness test, friability test, water absorption ratio, wetting time, disintegration test and dissolution test. These tablets are also well-known as mouth dissolving tablets and orodispersible tablets. This review article will emphasize on ideal properties, challenges, advantages, disadvantages, conventional techniques, patented technologies and evaluation of orodispersible tablets.
Effectiveness of Self Affirmation Exercises on control of Depression, Anxiety, and Stress among the Adolescents in the selected Destitute Home at Puducherry
Authors: Suvitha Suvitha , S Suriya. , U. K Sushree. , S Susila. , E Umadevi. , J. Umadevi.
Published: June 2022

Effectiveness of self-affirmation exercises on control of depression, anxiety, and stress among the adolescents in the selected destitute home at Puducherry. The objectives are (a) To assess the effectiveness of self-affirmation exercises on control of depression, anxiety and stress among the adolescents and to determine the association on pre-test level of depression, anxiety and stress of the adolescents with selected demographic variables. (b) To assess the effectiveness of self-affirmation exercises on control of depression, anxiety and stress among the adolescents residing in selected destitute home at Puducherry. (c) To evaluate the post-test level of depression, anxiety and stress among the adolescents. (d) To determine the association on pre-test level of depression, anxiety and stress of the adolescents with selected demographic variables. Pre experimental one group pre test post test design was adopted for the study. Convenient sampling technique was used to select the sample of 100 adolescents. They were assessed by using DASS SCALE. The data were analyzed in terms of both descriptive and inferential statistics. The study results proved that the effectiveness of self affirmation in controlling depression anxiety and stress was evident by comparison of pretest and post test level of depression, anxiety and stress using a paired ‘t’ test. The ‘t’ value of 0.740; 1.305; 1.566 showed that it was statistically highly significant at p<0.001 level which clearly showed that self affirmation exercises can be used in controlling depression anxiety and stress among adolescents.
Navigating Psychological Buffering effect of COVID 19
Authors: W Sampoornam. , Rachel Charles Hepsi
Published: June 2022

Studies in India have been more conceptual in nature and paucity of empirical evidence on assessing the psychological effects and response to COVID-19 has been observed. A rapid increase in the COVID cases and its debilitating impact on the psychological health necessitates an empirical investigation to explore the prevalence and determinants of psychological distress. Mental health professionals like psychologists, psychiatrists, psychiatric nurses and psychiatric social workers help the patients and larger community understand the potential impact of the virus and help patients, societies and families deal with the potential threat on physical and mental health.
Review on Diogenes Syndrome
Authors: KN Sarswathi
Published: June 2022

Diogenes syndrome is a behavioral-health condition characterized by poor personal hygiene, hoarding, and unkempt living conditions. It is most common in older men and women, which is why it is also called senile squalor syndrome. Persons with Diogenes syndrome demonstrate little concern for self-care or a clean living environment and seem frankly undisturbed about their condition or how others respond to it. It is thought that, in some cases, Diogenes is a response to late-in-life trauma, such as the loss of a long time spouse or caregiver. Treatment is often difficult because the individual resents intrusions on the way he or she is living, leading to resistance and a lack of cooperation.
Restless Legs Syndrome (RLS): An Overview
Authors: S Sarawad Shivaleela
Published: June 2022

Restless Legs Syndrome is a condition in which you have an uncontrollable urge to move your legs, frequently in response to a bad feeling. It frequently happens in the evening or at night, while you're seated or lying down. The discomfort is briefly relieved by moving around. Willis-Ekbom illness, often known as restless legs syndrome, can start at any age and gets worse over time. By disturbing sleep, it might cause problems with daily responsibilities. Simple self-care and lifestyle changes may be helpful in reducing symptoms. Many persons with RLS benefit from medication1.
Knowledge and Attitude of Nurse’s on Patient safety: A Systematic Review
Authors: Kavuluru VKSK Priyanka
Published: June 2022

Background of the review: Patient safety culture reflects the perception of processes, norms, and attitudes relating to a culture of preventable errors shared by health professionals in the delivery of care. Developing a culture of safety is a core element of many efforts to improve patient safety and care quality. Aim: The aim of the current review is intended (a) to assess the knowledge of nurses on patient safety (b) to assess the attitude of nurses on patient safety in clinical practice. Methods: The narrative conceptual synthesis method was used to review quantitative studies reporting sources of attitude of nurses towards patient safety culture. The search also was limited to studies conducted between 2011 and 2021 (10 years). The keywords include “patient safety culture”, “patient safety”, “attitude of nurses”, “clinical”, “hospitals” and “health care settings” in various combinations. Finally, 28 studies were identified, of which, 07met the set criteria. The review studies targeted on the student nurses, graduated nurses and nurses practicing in any patient care settings also included the data regarding patient safety culture. The researcher screened the literature and extracted the data. Results: The review results show that the nurses are having sufficient to good level of knowledge regarding patient safety with good practices. The attitude of nurses varies from 50%negative, 50% favorable to positive attitude regarding patient safety. Conclusion: Patient safety is a global health strategy and an ascribe of all health care systems. Nurses spend the maximum time round the clock in coordinating and providing care to the patients are highly involved in strengthening the safety web of patient care. Thus, the nursing staff must update their knowledge, foster a positive attitude regarding patient safety, and embody it into their practice to promote patient safety.
ANÁLISE PROSOPOGRÁFICA DA DIRETORIA DA ALIANÇA LIBERAL DO PARANÁ
Authors: Granato Natália Cristina
Published: June 2022

The Liberal Alliance represented the union of the dissident oligarchies of the states of Rio Grande do Sul, Minas Gerais and Paraíba in opposition to the hegemony of the São Paulo Republican Party for the choice of the official candidate for the presidency of the republic, during the 1930 elections. In state of Paraná, some local political leaders supported the Liberal Alliance. The work intends to investigate what are the social and political characteristics of the Liberal Alliance in Paraná and what were the novelties that this dissident grouping brought to the Paraná political scene, strongly marked by the political reproduction of the dominant groups through family ties. Through Pierre Bourdieu's theory, we will investigate what were the social, economic and political capitals that these agents carried from the survey of biographical data, through the prosopographical method, covering information such as place and year of birth, education, performance, the economic capitals, the main political positions held and the family and social connections of these agents in the political field of Paraná.
Depression, axiety and associated factors among young people during the second wave of Covid-19 in vietnam
Authors: Mai Pham Phuong , Hai Tran Nhu , Viet Trinh Dinh Minh , Van Hoang Thi Hai
Published: June 2022

This cross-sectional study was conducted nationwide with a sample size of 9.781 participants in order to describe the prevalence of depression and anxiety among Vietnamese youth (15-24 years old) during a COVID-19 outbreak and associated factors. The 21-item Depression, Anxiety and Stress Scale was used in this study. Results showed that 10% of the Vietnamese youth exhibited mild to extremely severe depression and 15.6% reported mild to extremely severe anxiety. Particularly, 1% of participants reported having severe or extremely severe symptoms of depression and 2.6% having severe or extremely severe symptoms of anxiety. Being christian or of other marital status or living in urban areas or having near poor or poor household income were all associated with increased depression among young people. Meanwhile, youth who were female, of ethnic minorities, Buddhist, Christian, or single, lived in urban areas, had only an elementary education, or had near low or low household income reported more anxiety symptoms. Findings from this study call for appropriate interventions to improve the mental health of the young population, especially in the context of COVID-19 pandemic.
The effectiveness of guided tissue regeneration treartment for furcation defect in mandible molars
Authors: Minh Nguyen Thi Hong , Minh Ho Thi Quynh
Published: June 2022

The study was conducted on 30 mandibular molars with grade II furcation defect to evaluate the results of treatment of furcation lesions by guided tissue regeneration surgery with Collagen membrane Result after 6 months post - op, the probing depth decreased to 3.5 ± 0.6 mm; the level of attachment loss decreased to 4.0 ± 0.7 mm. There was a statistically significant reduction in the probing depth and clinical attachment loss at 6 months post-op with GTR. Using collagen membranes for guided tissue regeneration (GTR) treatment showed good results, achieving treatment goals such as reducing pocket depth, restoring attachment, and improving periodontal indices.
Quality of life among the elderly with dementia in Hai Duong, Vietnam
Authors: Huong Vu Thu , Anh Nguyen Trung , Hung Nguyen Trong
Published: June 2022

Dementia seriously threatens the health and quality of life of the elderly and is a burden on families, communities, and society, especially in countries with rapid aging like growing Vietnam. A cross-sectional descriptive study using the EQ-5D-5L quality of life measurement scale on 104 elderly people with dementia was implementend in 6 communes of Thanh Mien district, Hai Duong province. The results showed that the mean score of quality of life is 0.3 ± 0.5. The percentage of dementia subjects who feel extremely difficult is higher than at all, slightly, moderately, severely of mobility, self-care, and usual activities (26.0%, 30.8%, and 32.7%, respectively). The results of the multivariable linear regression analysis showed that the factors related to the quality of life score were: activities of daily living, level of nicotine dependence, depression, and physical activity levels.
Thumb print patterns in relation to gender and blood groups: A study in central district of Tamil Nadu
Authors: Govindarajan Venkat Kumar  , Mani Anis Kumar  , Manickam Avinash  , Balasubramani Baranitharan
Published: June 2022

In the presentexamination, an endeavor has been made to study the fingerprint patterns in Central district of Tamil Nadu population. Thumb print patterns in relation with gender and blood group were studied in 275 participants,134 males and 141 females among the age group 18-25. The present study was conducted at the department of biotechnology, V.S.B. Engineering College, Karur district during the year 2022. Fingerprint patterns were studied in left and right thumb among males & females and analyzed with ABO blood grouping.The outcome demonstrated that the predominant pattern among both male and female was the loop, trailed by whorl and arches.
Secondary School Teachers’ Attitudes towards Teaching Profession
Authors: Win Padauk
Published: June 2022

The main aim of this study was to assess the attitude of secondary school teachers towards teaching profession. The study used descriptive method that involved collecting data to test the hypotheses and answer research questions. As study participants, all the basic education high schools in Sagaing city- developed area totalling 200 teachers were included. The attitude towards teaching profession was measured through the five dimensions: teaching, enjoyment in teaching, ideology, professional development and curriculum, and students. The study findings showed that the majority of secondary school teachers possess positive attitude towards teaching profession. Furthermore, the study showed that teachers with longer teaching experience have more positive attitude towards teaching profession. Similarly, the senior assistant teachers were found more positive compared to the junior assistant teachers. While the results provide fundamental data related to the commitment and motivation of the teachers, it has potential implication on the human resource management and talent management. As it was evident that teachers’ attitude towards teaching profession grow overtime, the results has long-term implication on the motivation, satisfaction and commitment of teachers as factors in staying positive to continuously contribute to the development of education in general and students in particular.
Mathematics Self-Efficacy and the Use of Virtual Math Manipulatives Among Pre-Service Teachers
Authors: Arida Rency , Andrade Rose , Mabilangan Rina
Published: June 2022

In response to the COVID-19 pandemic crisis, instructors' pedagogy has been modified, and technology-based educational tools have been implemented. However, little is known about pre-service teachers' self-efficacy in mathematics and their intentions in implementing such technology. Thus, the objective of this study is to test if perceived mathematics self-efficacy is significantly related to pre-service teachers’ behavioral intention to utilize virtual math manipulatives. The aim of the study was addressed through the use of a descriptive-correlational research design with sixty-nine (69) pre-service teachers. Students' mathematics self-efficacy and behavioral intention to utilize virtual math manipulatives were assessed using researcher-made questionnaires. It was discovered that a significant association exists between the respondents' content self-efficacy and their behavioral intention to utilize virtual math manipulatives as to attitude, subjective norms, and perceived behavioral control. A similar relationship exists between self-efficacy and behavioral intention to use virtual math manipulatives in terms of attitude and behavioral control. The results imply that applying virtual manipulatives is anchored on knowledge and confidence of process and purpose. Therefore, preparing pre-service teachers for the classroom through a variety of training and seminars will help them improve their mathematics self-efficacy while also increasing their intention to use virtual manipulatives.
Law and globalization
Authors: Setiawan Yudha , Kristhy Mutia Evi , Arafah Reny , Kristalina Kristalina
Published: June 2022

The aim of this study was to examine global regulatory governance and its impact on legal and economic development. This study was normative legal research using primary and secondary legal materials. The technique of collecting legal materials used was literature study and processed by deduction. Furthermore, it was analyzed qualitatively. The results of the study indicated that global regulatory governance was basically sovereignty. Global regulatory governance appeared as a milestone that had a positive impact on the development of Indonesian law, namely the simplification of existing regulations to build a good regulatory management system. The existing ones are effective in addressing policy issues, and were kept as intended. Besides, global regulatory governance also had a positive impact on the Indonesian economy. Thus, global regulatory governance through the Omnibus Law, licensing investment to Indonesia will be faster and easier and the economy is expected to turn around soon. Rapid investment will also encourage the growth of small, micro, and medium enterprises to absorb labor. That way the Indonesian economy after the Covid-19 pandemic will return to stability.
Dimocarpus longan phytocompounds possess anticancer activity by specifically targeting breast cancer biomarkers via computational biology tools
Authors: Elengoe Asita , Suhaibun Sherman Ryner
Published: June 2022

Worldwide, breast cancer (BC) is the most common cancer among women. Natural plant compounds with anticancer potential can block BC biomarkers, but they must be chosen carefully to avoid adverse side effects. In this research, the interaction between the BC biomarkers and plant compounds from Dimocarpus Longan was studied using a molecular docking approach. Twenty plant constituents from longan and two target proteins considered involved in BC (1ERR: Estrogen receptor and 3D90: Progesterone receptor) were obtained from the PubChem database and RCSB Protein Data Bank (PDB) respectively. They were docked using the SwissDock server. Then, the drug-likeness of the plant compounds that demonstrated interaction was evaluated. The results show that 1ERR and 3D90 had the lowest binding affinity with the L-epicatechin at the value of -9.5 and -8.3 kcal/mol respectively. These proteins had the most stable interaction with their plant compounds. The toxicity prediction analysis revealed that L-epicatechin is not safe to use as a drug due to AMES toxicity. All of the ten compounds had low binding scores, indicating that they had good interactions. Therefore, α-terpineol was chosen to use as a safe drug. The findings of this study should aid pharmaceutical researchers in identifying longan-based medications.
Development and validation of RP-HPLC method for determination of ketorolac tromethamine from bulk and pharmaceutical formulations
Authors: Pawar Sarita , Punekar Aditi , Gosavi Seema , Gorde Prasad , Harak Shilpa
Published: June 2022

A simple, rapid, specific, precise and accurate Reverse phase high performance liquid chromatographic (RP-HPLC) method was developed for quantitative analysis of Ketorolac tromethamine in bulk and marketed formulations such as tablet, ophthalmic solution and gel and validated as per ICH guidelines. Chromatographic separation was performed on a C18 column using an optimized mobile phase of Methanol: Water (75:25) at a flow rate of 1ml/min using the HPLC method. The detection was done at 319 nm and Ketorolac tromethamine had a retention time 2.522 minutes. The total run time of analysis was 10minutes. The drug obeyed Beers law in the concentration range of 4-12µg/ml and the calibration plot revealed a linear relationship. The LOD and LOQ for ketorolac tromethamine were determined to be 0.415 µg/ml and 1.3 µg/ml, respectively. The accuracy and repeatability studies of the proposed method was found to be in acceptable limits, %RSD was less than 2. The proposed method showed excellent linearity, specificity, accuracy, precision, LOD, LOQ and system suitability results within the acceptance criteria.
Ileostomy closure
Authors: Gandhi Jenit P. , Jasani Rakesh , Shah Aditya , Chaudhari Ohang
Published: June 2022

Introduction: Faecal diversion is an effective procedure to protect bowel anastomosis at high risk for leak. Loop ileostomy is more or less acceptable method for faecal diversion. Some concerns still exist regarding the risk for a significant morbidity and complications associated to ileostomy creation itself and moreover to its closure. Surgical expertise and closure techniques are considered potential factors influencing mortality. Aim of the study is to present a single institutional experience with ileostomy closures, in a high-volume training hospital, where ileostomy reversal is mainly performed by young surgeons. Methods: A retrospective study was done to evaluate data of patients who underwent loop ileostomy and ileostomy closure between June 2017 to June 2021 at Dhiraj Hospital Sumandeep Vidyapeeth , Pipariya , vadodara. Ileostomy closure was always done in hand-sewn fashion, performing either a direct closure (DC) or a resection plus end-to-end anastomosis (EEA). Postoperative morbidity was graded according to Clavien-Dindo classification. Outcomes after both methods were compared by Fisher’s exact test and Wilcoxon rank-sum test. Results: Hundred and four patients were included. Ileostomy reversal was performed by EEA in 86 patients (82.69%) and by DC in 18 patients (17.30%). Surgery was performed with a peristomal access in 93 cases (89.42%).