bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative Nursing Management of Sleep
Authors: Cuellar Norma G.
Published: August 2014

The importance of sleep is increasingly recognized as a contributor to health outcomes across the lifespan. Almost two thirds of the population report sleep problems at least twice per week, resulting in daytime sleepiness and dysfunction. Direct and indirect costs of sleep problems are in the billions of dollars and contribute to accidents and chronic conditions. All health care providers need to understand how to facilitate restful high quality sleep, a necessary component for health and well-being. An integrative approach considers all of the factors associated with poor sleep and individually structures interventions that mitigate impediments to sleep.
Integrative Nursing Management of Pain
Authors: Wagner Judy L. , Thompson Susan
Published: August 2014

Pain affects everyone universally regardless of age, gender or ethnicity, and is one of the most common reasons patients seek medical care. Despite this, treatments for pain continue to be underutilized and inadequate. The burden of pain on mindbodyspirit is enormous and has a significant effect on an individual’s quality of life and society as a whole. This chapter offers a holistic approach to pain management through the use of mind-body techniques, energy therapies, acupressure, massage and movement therapies that can help an individual take a more active role in their pain management.
Integrative Nursing Care of the Human Spirit
Authors: Quinn Janet F.
Published: August 2014

Life’s big questions and the search for meaning underlie all spiritual issues in healthcare, and so, conscious or not, the issues are already there. Thus, while the symptom of “spiritual distress” can arise in the healthcare context, it is important to identify it as a subset of a much larger focus for integrative nurses, namely, tending the human spirit. This chapter will explore an integrative nursing approach to spirituality: how the integrative nurse tends the human spirit and addresses the symptom of spiritual distress if, and when, it arises.
Integrative Nursing in Acute Care Settings
Authors: Knutson Lori , Lincoln Valerie
Published: August 2014

Over the past ten years, there has been significant growth in the number of hospitals offering integrative therapies. A strong clinical and business case is emerging that is fueled by consumer demand and the expanding evidence base that demonstrates positive outcomes. Two exemplars of hospitals are highlighted where integrative nursing principles and concepts are deeply woven into the care model. In both institutions highlighted, aligning integrative health with organizational vision, mission and priorities was critical to success. Nurses are well positioned to provide leadership in advancing integrative health and nursing within acute care settings.
Integrative Nursing and the Environment
Authors: Luck Susan
Published: August 2014

In today’s modern world, we all face many challenges for maintaining health and preventing disease. Exposure to environmental toxins and pollution are stressors contributing to many of the growing health issues that we face throughout the lifecycle globally including immune dysfunction, hormonal imbalances, inflammatory conditions, neurological problems. Today, as never before, nursing as a profession, needs to stay informed of the impact of our environment on health and well being. With new knowledge, nurses can educate and advocate for healthier communities and a healthier world and continue our nursing legacy as environmentalists.
Continuing Professional Development for Integrative Nursing
Authors: Koithan Mary , Chappell Kathy
Published: August 2014

Nursing professional development (NPD) is a career-long continuum of formal and informal educational activities informed by wide-ranging sources of clinical, practice, scientific and theoretical evidence. An environmental scan indicates a plethora of professional development opportunities in integrative nursing with offerings across multiple learning platforms (symposia and conferences, residential intensives, online asynchronous sessions, asynchronous media-supported classes and agency-supported in-service sessions) and multiple venues. Several professional organizations, universities, and private companies offer opportunities to develop knowledge, skills, and abilities that prepare nurses to competently care for self and patients.
Integrative Nursing and Health Literacy
Authors: Westra Bonnie L. , Weinfurter Elizabeth Fine , Delaney Connie W.
Published: August 2014

Health literacy is the degree to which an individual has the capacity to obtain, communicate, process, and understand basic health information and services to make appropriate health decisions. Health literacy is a complex multidimensional issue and involves more than reading skills. Low health literacy is associated with poorer health outcomes and higher costs of care. In this chapter, definitions of health literacy dimensions and methods to assessment and interventions to address these are discussed. Multiple resources are included for improving health literacy.
Integrative Nursing in Germany
Authors: Ammende Ranier , Tewes Renate
Published: August 2014

This chapter explores already establishes complementary nursing concepts which will further the introduction of integrative nursing into Germany. A short outline of nurse education and current issues in the German health care system describe the challenges lying ahead.
Integrative Nursing in Turkey
Authors: Gözüm Sebahat , Platin Nurgün
Published: August 2014

While there is strong interest in the use of integrative therapies in Turkey, their availability within acute care settings remains modest. Traditional Turkish practices include thermal baths, Turkish massage (hamam), cupping and use of leeches. Consumers commonly access these approaches as well as other integrative therapies. Nurses are well educated in Turkey, a country that has long offered nursing education at the baccalaureate degree. However, the medical model is still very dominant. To advance integrative nursing within Turkey, nursing needs to embrace a shift in paradigm that includes re-defining nursing and its status quo and there continues to be a need to advance nursing research and innovative education.
Integrative Nursing in the United Kingdom
Authors: Smith Susan , Sweetenham Janina , Bradshaw Angela
Published: August 2014

This chapter explores integrative nursing in the United Kingdom. It is postulated that the term “integrative nursing” is not commonly found in U.K. literature. Instead, “holistic nursing,” “person-centered care,” and “therapeutic relationships” are major areas of emphasis that are aligned with the integrative nursing construct. A case study illuminates the essence of integrative nursing in practice in the U.K. by referring to an approach called the “Caring Behaviours Assurance System” CBAS© which has been implemented by NHS Scotland in 2011. This approach is both an educational development for healthcare staff and also an accountability and assurance model for organizations seeking to assure the presence of “holistic nursing” “person centered care” and therapeutic relationships in practice. The goal is to care for patients and staff using an integrated systems approach.
Integrative Nursing in Iceland
Authors: Kristofersson Gisli , Gunnarsdottir Thora Jenny
Published: August 2014

Icelandic entry level nurses remain one of the best educated in the world and appear to have a positive attitude regarding integrative approaches as do many of their patients. A more organized effort is needed in Icelandic health care facilities and by Icelandic nurses and educators to develop and promote integrative nursing in Iceland. There is a unique opportunity for further growth in integrative nursing in Iceland due to the excellent educational background of nurses in Iceland, its unique proximity to various natural resources and a broad cultural acceptance of integrative modalities in Iceland.
Duodenum
Authors: Johnson C. Daniel
Published: August 2014

Cases are presented related to inflammatory and ulcerative diseases, masses and filling defects, and miscellaneous conditions of the duodenum. Each case contains a relevant image or images, imaging findings, a differential diagnosis, the actual diagnosis, and a discussion. Supplementary materials provided with each chapter include differential diagnoses, anatomical illustrations, and a question and answer section.
Small Bowel
Authors: Johnson C. Daniel
Published: August 2014

Cases are presented related to masses and filling defects, diffuse and segmental diseases, and common and miscellaneous conditions of the small bowel. Each case contains a relevant image or images, imaging findings, a differential diagnosis, the actual diagnosis, and a discussion. Supplementary materials provided with each chapter include differential diagnoses, anatomical illustrations, and a question and answer section.
Bile Ducts and Gallbladder
Authors: Johnson C. Daniel
Published: August 2014

Cases are presented related to inflammatory diseases, masses and filling defects, and miscellaneous conditions of the bile ducts and gallbladder. Each case contains a relevant image or images, imaging findings, a differential diagnosis, the actual diagnosis, and a discussion. Supplementary materials provided with each chapter include differential diagnoses, anatomical illustrations, and a question and answer section.
Pancreas
Authors: Johnson C. Daniel
Published: August 2014

Cases are presented related to inflammatory diseases, masses, and miscellaneous conditions of the pancreas. Each case contains a relevant image or images, imaging findings, a differential diagnosis, the actual diagnosis, and a discussion. Supplementary materials provided with each chapter include differential diagnoses, anatomical illustrations, and a question and answer section.
Spleen
Authors: Johnson C. Daniel
Published: August 2014

Cases are presented related to masses, and miscellaneous conditions of the spleen. Each case contains a relevant image or images, imaging findings, a differential diagnosis, the actual diagnosis, and a discussion. Supplementary materials provided with each chapter include differential diagnoses, anatomical illustrations, and a question and answer section.
Peritoneum and Mesentery
Authors: Johnson C. Daniel
Published: August 2014

Cases are presented related to fluid and masses, hernias, and miscellaneous conditions of the peritoneum and mesentery. Each case contains a relevant image or images, imaging findings, a differential diagnosis, the actual diagnosis, and a discussion. Supplementary materials provided with each chapter include differential diagnoses, anatomical illustrations, and a question and answer section.
Redundancy of primary RNA-binding functions of the bacterial transcription terminator Rho
Authors: Shashni Rajesh , Qayyum M. Zuhaib , Vishalini V. , Dey Debashish , Sen Ranjan
Published: August 2014

The bacterial transcription terminator, Rho, terminates transcription at half of the operons. According to the classical model derived from in vitro assays on a few terminators, Rho is recruited to the transcription elongation complex (EC) by recognizing specific sites (rut) on the nascent RNA. Here, we explored the mode of in vivo recruitment process of Rho. We show that sequence specific recognition of the rut site, in majority of the Rho-dependent terminators, can be compromised to a great extent without seriously affecting the genome-wide termination function as well as the viability of Escherichia coli. These terminators function optimally only through a NusG-assisted recruitment and activation of Rho. Our data also indicate that at these terminators, Rho-EC-bound NusG interaction facilitates the isomerization of Rho into a translocase-competent form by stabilizing the interactions of mRNA with the secondary RNA binding site, thereby overcoming the defects of the primary RNA binding functions.
Xanthomonas axonopodis Virulence Is Promoted by a Transcription Activator-Like Effector–Mediated Induction of a SWEET Sugar Transporter in Cassava
Authors: Cohn Megan , Bart Rebecca S. , Shybut Mikel , Dahlbeck Douglas , Gomez Michael , Morbitzer Robert , Hou Bi-Huei , Frommer Wolf B. , Lahaye Thomas , Staskawicz Brian J.
Published: August 2014

The gene-for-gene concept has historically been applied to describe a specific resistance interaction wherein single genes from the host and the pathogen dictate the outcome. These interactions have been observed across the plant kingdom and all known plant microbial pathogens. In recent years, this concept has been extended to susceptibility phenotypes in the context of transcription activator-like (TAL) effectors that target SWEET sugar transporters. However, because this interaction has only been observed in rice, it was not clear whether the gene-for-gene susceptibility was unique to that system. Here, we show, through a combined systematic analysis of the TAL effector complement of Xanthomonas axonopodis pv. manihotis and RNA sequencing to identify targets in cassava, that TAL20Xam668 specifically induces the sugar transporter MeSWEET10a to promote virulence. Designer TAL effectors (dTALE) complement TAL20Xam668 mutant phenotypes, demonstrating that MeSWEET10a is a susceptibility gene in cassava. Sucrose uptake–deficient X. axonopodis pv. manihotis bacteria do not lose virulence, indicating that sucrose may be cleaved extracellularly and taken up as hexoses into X. axonopodis pv. manihotis. Together, our data suggest that pathogen hijacking of plant nutrients is not unique to rice blight but also plays a role in bacterial blight of the dicot cassava.
Genetic Characterization of Resistance to Wheat Stem Rust Race TTKSK in Landrace and Wild Barley Accessions Identifies the rpg4/Rpg5 Locus
Authors: Mamo Bullo Erena , Smith Kevin P. , Brueggeman Robert S. , Steffenson Brian J.
Published: August 2014

Race TTKSK of the wheat stem rust pathogen (Puccinia graminis f. sp. tritici) threatens the production of wheat and barley worldwide because of its broad-spectrum virulence on many widely grown cultivars. Sources of resistance against race TTKSK were recently identified in several barley landraces (Hordeum vulgare subsp. vulgare) and wild barley accessions (H. vulgare subsp. spontaneum). The objectives of this study were to characterize the inheritance of resistance to wheat stem rust race TTKSK in four barley landraces (Hv501, Hv545, Hv602, and Hv612) and two wild barley (WBDC213 and WBDC345) accessions, map the resistance genes, and determine the allelic relationships among the genes in these accessions and the previously described rpg4/Rpg5 locus. Resistant accessions were crossed with the susceptible cv. Steptoe and resulting F3 populations were evaluated for resistance to race TTKSK at the seedling stage. Segregation of F3 families in populations involving the resistance sources of Hv501, Hv545, Hv612, WBDC213, and WBDC345 fit a 1:2:1 ratio for homozygous resistant (HR)/segregating (SEG)/homozygous susceptible (HS) progenies (with χ2 = 2.27 to 5.87 and P = 0.053 to 0.321), indicating that a single gene confers resistance to race TTKSK. Segregation of F3 families in cross Steptoe/Hv602 did not fit a 1:2:1 ratio (HR/SEG/HS of 20:47:43 with χ2 = 11.95 and P = 0.003), indicating that more than one gene is involved in imparting resistance to race TTKSK. Bulked segregant analysis using >1,500 single-nucleotide polymorphism markers positioned a resistance locus in all six populations on chromosome 5HL in very close proximity to the known location of the rpg4/Rpg5 complex locus. Allelism tests were conducted by making crosses among resistant accessions Hv501, Hv545, and Hv612 and also Q21861 with the rpg4/Rpg5 complex. No segregation was observed in F2 families inoculated with race TTKSK, demonstrating that all Hv lines carry the same allele for resistance and that it resides at or very near the rpg4/Rpg5 locus. Phenotype evaluations of the six barley accessions with wheat stem rust race QCCJ revealed resistant infection types (ITs) at a low incubation temperature and susceptible ITs at a high incubation temperature, similar to Q21861, which carries the temperature-sensitive gene rpg4. The accessions also exhibited low ITs against the rye stem rust isolate 92-MN-90, suggesting that they also carry Rpg5. This result was confirmed through molecular analysis, which revealed that all six barley accessions contain the serine threonine protein kinase domain that confers Rpg5 resistance. These results indicate that cultivated barley is extremely vulnerable to African stem rust races such as TTKSK because even these diverse selections of landrace and wild barley accessions carry only one locus for resistance.
Presentation of a Quality Management Program in Off-Pump Coronary Bypass Surgery
Authors: Bougioukakis Petros , Kluegl Stefan J. , Babin-Ebell Joerg , Tagarakis Giorgios I. , Mandewirth Martin , Zacher Michael , Diegeler Anno
Published: August 2014

Objective

To increase the number of off-pump coronary procedures at our institution, a new surgical team was formed. The first 3 years of “learning period” were accompanied by a quality management program aimed to control and adjust the surgical process and to ensure the safety and quality of the procedure.

Methods

All patients were operated on by the same surgeon between January 2004 and December 2006; all procedures were performed under the following quality management protocol. First, a flow chart regulated surgical and anesthetic details. Second, an online file, named “disturbance file,” was used to report work flow interruption, disturbance, and intraoperative events, that is, myocardial ischemia, hypotension, conversion to cardiopulmonary bypass, and any violation of the protocol. Each event was coded with 1 point and added to a score (the higher the score is, the greater the disturbance). Outcome parameters known as major events—major cardiac and cerebral events: mortality within 30 days/myocardial infarction confirmed by electrocardiogram or significantly high levels of total creatine kinase-myocardial muscle creatine kinase/reintervention within 30 days/stroke—and new-onset dialysis were also measured. Success was defined as freedom from any of those events and depicted in a cumulative sum control (CUSUM) chart. Outcome data and CUSUM were correlated with the intraoperative Disturbance Index.

Results

In total, 490 off-pump coronary bypass operations were performed by the named surgeon during the study period. The 30-day mortality was reduced from 4.0% to 1.9%. Disturbance Index score of greater than 1 declined from 41.6% to 23.3%. All major cardiac and cerebral events declined. The CUSUM chart showed two critical periods during the learning period, which made an adjustment of the protocol necessary.

Conclusions

Quality management control is efficient in improving the postoperative results of a surgical procedure. A learning period is of cardinal importance for any new team wishing to engage in a novel surgical technique.
Nonintubated Thoracoscopic Pulmonary Nodule Resection under Spontaneous Breathing Anesthesia with Laryngeal Mask
Authors: Ambrogi Marcello C. , Fanucchi Olivia , Korasidis Stylianos , Davini Federico , Gemignani Raffaello , Guarracino Fabio , Melfi Franca , Mussi Alfredo
Published: August 2014

Objective

During the past 20 years, the use of video-assisted thoracoscopic surgery has increased as an important minimally invasive tool. To further reduce its invasiveness, after a preliminary experience, we decided to use a nonintubated spontaneous breathing general anesthesia, for video-assisted thoracoscopic surgery resection of lung nodule, using a laryngeal mask (LMA). This study aimed to verify the safety and the feasibility of this technique.

Methods

Twenty consecutive patients who underwent thoracoscopic wedge of lung nodule under spontaneous breathing general anesthesia with LMA are the subjects of this study. Clinical data, American Society of Anesthesiologists status, Adult Comorbidity Evaluation-27 score, and Revised Cardiac Risk Index score were recorded for each patient. General inhalatory anesthesia (sevoflurane) was given in all cases through an LMA, without muscle relaxants, thus allowing spontaneous breathing. All procedures were performed in the lateral decubitus position. The maximum and minimum values of end-tidal carbon dioxide tension and oxygen saturation were recorded during the procedure. The level of technical feasibility was stratified by the operating surgeon according to four levels: excellent, good, satisfactory, and unsatisfactory.

Results

There were 13 men and 7 women (mean age, 57 years). The mean induction anesthesia time was 6 minutes, whereas the mean operative time was 38 minutes. The values of oxygen saturation as well as minimum and maximum end-tidal carbon dioxide tension were 99.1%, 33.6 mm Hg, and 39.1 mm Hg, respectively. No mask displacement occurred. The mean operative time was 38 minutes (range, 25–90 minutes). The level of technical feasibility was defined as excellent in 19 cases and good in 1 case. No mortality occurred. Morbidity consisted of pleural effusion (one case), which was medically resolved. The mean postoperative stay was 3.5 days. Histopathologic results were one squamous cell lung cancer (lung primary), one adenocarcinoma (lung primary), five metastasis from colon cancer, four metastasis from breast cancer, three metastasis from renal cancer, three sarcoidosis, two amartocondroma, and one tuberculosis.

Conclusions

Our experience suggests that thoracoscopic wedge resection of lung nodule is safe and feasible under spontaneous breathing anesthesia with LMA. This technique permits a confident manipulation of lung parenchyma and a safe stapler positioning, without cough, pain, or panic attack described for awake epidural anesthesia, avoiding the risks related to tracheal intubation and mechanical ventilation.
Robotic Mitral Valve Replacement for Severe Rheumatic Mitral Disease: Perioperative Technique, Outcomes, and Early Results
Authors: Senay Sahin , Gullu Ahmet Umit , Kocyigit Muharrem , Degirmencioglu Aleks , Kilic Leyla , Karabulut Hasan , Alhan Cem
Published: August 2014

Objective

We report a case series of robotic mitral valve replacement in patients with severe rheumatic mitral disease.

Methods

From March 2010 to June 2013, a total of 63 patients underwent robotic cardiac procedures. Robotic procedures were performed using the da Vinci Si surgical systems (Intuitive Surgical, Inc, Sunnyvale, CA USA). Eighteen of the patients (28.5%) underwent robotic mitral valve replacement. Rheumatic disease was the underlying pathology in all patients. The mean (SD) follow-up period was 18 (10) months.

Results

The mean (SD) age and EuroSCORE of the patients were 51.2 (11) years and 4.1% (4%), respectively. Seven patients (38.8%) had an additional cardiac procedure. No operative and hospital mortality were observed. The mean (SD) cross-clamp time and cardiopulmonary bypass time were 116 (30) and 178 (54) minutes, the mean (SD) drainage was 430 (350) mL, the mean intubation time was 9.4 (7) hours, the rate of patients extubated within 6 hours or less was 94.4%, and the mean (SD) intensive care unit stay time was 30 (12) hours. Sixteen of the patients (88.8%) were discharged from the intensive care unit within the first 24 hours postoperatively. During the intensive care unit stay, one patient (5.5%) needed inotropic support. There was one early reoperation for bleeding (5.5%), one (5.5%) intensive care unit readmission, and one (5.5%) hospital readmission observed. During the midterm follow-up, there was no mortality and no need for reoperation or reintervention.

Conclusions

Robotic mitral valve replacement for severe rheumatic mitral disease is technically feasible. Early results are encouraging. Patient selection criteria for robotic mitral valve surgery may be expanded to include valve replacements.
Transcervical Wedge Resection after Transcervical Extended Mediastinal Lymphadenectomy
Authors: Kim Anthony W. , Kull David R. , Zieliński Marcin , Boffa Daniel J. , Detterbeck Frank C.
Published: August 2014

Transcervical extended mediastinal lymphadenectomy (TEMLA) has been shown to be feasible and safe. This approach may be underrecognized for providing excellent access to the pleural space. We present a 60-year-old woman who had a clinical stage T2b N0 M0 adenocarcinoma of her right lower lobe and several ground glass opacities throughout her upper lobes bilaterally. She underwent a TEMLA to confirm absence of lymph node involvement in her mediastinum. During the same anesthetic setting, a transpleural right upper lobe wedge resection via the cervical approach was performed as an extension of her TEMLA. The pathology from this wedge resection demonstrated atypical adenomatous hyperplasia. Ultimately, she underwent a thoracoscopic right lower lobectomy that confirmed that she had a pathologic T2b N0 M0 (5.0 × 4.0 × 3.0 cm) adenocarcinoma. There were no perioperative adverse events with either operation. Transcervical extended mediastinal lymphadenectomy and transcervical lung resections may be performed safely during the same anesthetic setting.
Thermococcus paralvinellae sp. nov. and Thermococcus cleftensis sp. nov. of hyperthermophilic heterotrophs from deep-sea hydrothermal vents
Authors: Hensley Sarah A. , Jung Jong-Hyun , Park Cheon-Seok , Holden James F.
Published: August 2014

Two heterotrophic hyperthermophilic strains, ES1T and CL1T, were isolated from Paralvinella sp. polychaete worms collected from active hydrothermal vent chimneys in the north-eastern Pacific Ocean. Both were obligately anaerobic and produced H2S in the presence of elemental sulfur and H2. Complete genome sequences are available for both strains. Phylogenetic analyses based on 16S rRNA gene sequences showed that the strains are more than 97 % similar to most other species of the genus

Thermococcus

. Therefore, overall genome relatedness index analyses were performed to establish that these strains are novel species. For each analysis, strain ES1T was determined to be most similar to

Thermococcus barophilus

MPT, while strain CL1T was determined to be most similar to

Thermococcus sp.

4557. The average nucleotide identity scores for these strains were 84 % for strain ES1T and 81 % for strain CL1T, genome-to-genome direct comparison scores were 23 % for strain ES1T and 47 % for strain CL1T, and the species identification scores were 89 % for strain ES1T and 88 % for strain CL1T. For each analysis, strains ES1T and CL1T were below the species delineation cut-off. Therefore, based on their whole genome sequences, strains ES1T and CL1T are suggested to represent novel species of the genus

Thermococcus

for which the names Thermococcus
paralvinellae sp. nov. and Thermococcus cleftensis sp. nov. are proposed, respectively. The type strains are ES1T ( = DSM 27261T = KACC 17923T) and CL1T ( = DSM 27260T = KACC 17922T).
Crystal structure of 2-cyano-N′-(cyclohexylidene)acetohydrazide
Authors: Harrison William T. A. , Al-Sakka Ola K. , Fleita Daisy H. , Saleh Amina , Salem Sara
Published: August 2014

In the title compound, C9H13N3O, the cyclohexylidene ring adopts a chair conformation and the bond-angle sum at the C atom linked to the N atom is 359.6°. The cyanoacetohydrazide grouping is close to planar (r.m.s. deviation for the non-H atoms = 0.031 Å) and subtends a dihedral angle of 64.08 (4)° with the four C atoms forming the seat of the chair. The C=O and N—H groups are in asynconformation (O—C—N—H = −5°). In the crystal, inversion dimers linked by pairs of N—H...O hydrogen bonds generateR22(8) loops; this dimer linkage is reinforced by a pair of C—H...O interactions, which generateR22(14) loops. The dimers are linked by C—H...Nc(c = cyanide) interactions into [100] ladders, which featureC(4) chains andR44(20) loops.
Crystal structure ofN,N′-bis(diisopropylphosphanyl)-4-methylpyridine-2,6-diamine
Authors: Stöger Berthold , Weil Matthias , Bichler Bernhard , Eder Wolfgang , Kirchner Karl
Published: August 2014

In the molecule of the title compound, C18H35N3P2, the methylpyridine-2,6-diamine moiety is almost planar, with a maximum deviation of 0.0129 (9) Å for one of the amine N atoms. Whereas one of the P atoms is co-planar with this mean plane [deviation = 0.0158 (10) Å], the other P atom is considerably displaced out of the mean plane by 0.5882 (10) Å. In the crystal, no directional intermolecular interactions beyond van der Waals contacts could be identified.
Crystal structure of (E)-1-(4-chlorophenyl)ethanoneO-dehydroabietyloxime
Authors: Zheng Jian-Qiang , Cui Yan-Jie , Rao Xiao-Ping
Published: August 2014

The title compound, C28H34ClNO2{systematic name: (E)-1-(4-chlorophenyl)ethanoneO-[(1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl]oxime}, was synthesized from dehydroabietic acid. In the dehydroabietyl moiety, the central and terminal cyclohexane rings display chair and half-chair conformations, respectively, and atrans-ring junction. The C=N bond is in anEconformation and the C—O—N=C torsion angle is 148.1 (5)°. No directional interactions except van der Waals contacts occur in the crystal structure.
Crystal structure of a monoclinic polymorph of 5-amino-1,3,4-thiadiazol-2(3H)-one
Authors: Kim Namhun , Kang Sung Kwon
Published: August 2014

The title compound, C2H3N3OS, is a monoclinic (P21/c) polymorph of the previously reported triclinic structure [Kanget al.(2012).Acta Cryst.E68, o1198]. The asymmetric unit contains two independent molecules which are essentially planar, with r.m.s. deviations of 0.001 and 0.032 Å from the mean plane defined by the seven non-H atoms. In the crystal, N—H...N and N—H...O hydrogen bonds link the molecules into a sheet parallel to (111).
Crystal structure of 8-hydroxyquinoline: a new monoclinic polymorph
Authors: Castañeda Raúl , Antal Sofia A. , Draguta Sergiu , Timofeeva Tatiana V. , Khrustalev Victor N.
Published: August 2014

In an attempt to grow 8-hydroxyquinoline–acetaminophen co-crystals from equimolar amounts of conformers in a chloroform–ethanol solvent mixture at room temperature, the title compound, C9H7NO, was obtained. The molecule is planar, with the hydroxy H atom forming an intramolecular O—H...N hydrogen bond. In the crystal, molecules form centrosymmetric dimersviatwo O—H...N hydrogen bonds. Thus, the hydroxy H atoms are involved in bifurcated O—H...N hydrogen bonds, leading to the formation of a central planar four-membered N2H2ring. The dimers are bound by intermolecular π–π stacking [the shortest C...C distance is 3.2997 (17) Å] and C—H...π interactions into a three-dimensional framework. The crystal grown represents a new monoclinic polymorph in the space groupP21/n. The molecular structure of the present monoclinic polymorph is very similar to that of the orthorhombic polymorph (space groupFdd2) studied previously [Roychowdhuryet al.(1978).Acta Cryst.B34, 1047–1048; Banerjee & Saha (1986).Acta Cryst.C42, 1408–1411]. The structures of the two polymorphs are distinguished by the different geometries of the hydrogen-bonded dimers, which in the crystal of the orthorhombic polymorph possess twofold axis symmetry, with the central N2H2ring adopting a butterfly conformation.
Crystal structure of 1-(4-formylbenzylidene)-4-methylthiosemicarbazone
Authors: Pino-Cuevas Arantxa , Carballo Rosa , Vázquez-López Ezequiel M.
Published: August 2014

The structure of the title compound, C10H11N3OS, comprises an approximately planar molecule, with the r.m.s. deviation for the 15 non-H atoms being 0.089 Å. The conformation about the imine bond isEand an intramolecular N—H...N hydrogen bond is evident. Molecules are linked into a supramolecular chain along thebaxis by N—H...S hydrogen bonds.
Crystal structure of bis{μ-4-methyl-N′-[3-(oxidoimino)butan-2-ylidene]benzenesulfonohydrazidato}bis[(dimethyl sulfoxide-κO)copper(II)]
Authors: Siqueira Diego Pereira , Siqueira Maria Carolina Bulhosa , Gervini Vanessa Carratu , Bresolin Leandro , Oliveira Adriano Bof de
Published: August 2014

In the title compound, [Cu2(C11H13N3O3S)2(C2H6OS)2], the CuIIcation isN,N′,O-chelated by a deprotonated hydroxyimino-tosylhydrazone ligand and coordinated by a dimethyl sulfoxide molecule. One O atom from the adjacent hydroxyimino-tosylhydrazone ligand bridges the CuIIcation, forming the centrosymmetric dimeric complex. The cation is in an overall distorted N2O3square-pyramidal coordination environment. The methylbenzene ring is twisted with respect to the hydrazine fragment, with a dihedral angle of 89.54 (9)° between the planes. An intramolecular C—H...O hydrogen bond occurs. In the crystal, molecules are linked by weak C—H...O and C—H...S interactions. Weak π–π stacking is also observed between parallel benzene rings of adjacent molecules, the centroid–centroid distance being 3.9592 (17) Å.
Crystal structure of ethyl 2-({[(4Z)-3,5-dioxo-1-phenylpyrazolidin-4-ylidene]methyl}amino)acetate
Authors: Mohamed Shaaban K. , Akkurt Mehmet , Mague Joel T. , Ahmed Eman A. , Albayati Mustafa R.
Published: August 2014

The title compound, C14H15N3O4, is nearly planar, the dihedral angle between the planes of the phenyl and pyrazolidine rings being 1.13 (7) Å, and that between the plane of the pyrazolidine ring and the mean plane of the side chain [C—N—C–C(=O)—O; r.m.s. deviation = 0.024 Å] being 2.52 (7)°. This is due in large part to the presence of the intramolecular N—H...O and C—H...O hydrogen bonds. In the crystal, pairwise N—H...O hydrogen bonds form inversion dimers, which are further associated into layers, lying very close to plane (-120),viapairwise C—H...O hydrogen bonds. The layers are then weakly connected through C—H...O hydrogen bonds, forming a three-dimensional structure.
Crystal structure of (E)-N-(3,4-dimethoxybenzylidene)morpholin-4-amine
Authors: Çelikesir Sevim Türktekin , Akkurt Mehmet , Jarrahpour Aliasghar , Büyükgüngör Orhan
Published: August 2014

In the title compound, C13H18N2O3, the benzene ring makes a dihedral angle of 17.19 (11)° with the least-squares plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation. In the crystal, C—H...N hydrogen bonds link the molecules into supramolecular chains running along a 21screw axis parallel to theb-axis direction. Weak C—H...π interactions are also observed.
Crystal structure of (Z)-3-benzyloxy-6-[(2-hydroxy-5-methylanilino)methylidene]cyclohexa-2,4-dien-1-one
Authors: Ghichi Nadir , Benosmane Ali , Benboudiaf Ali , Merazig Hocine
Published: August 2014

In the title Schiff base compound, C21H19NO3, the conformation about the C=C bond isZ. The N—H group and carbonyl O atom form an intramolecular N—H...O hydrogen bond with anS(6) ring motif. The benzyloxy ring and the 2-hydroxy-5-methylphenyl ring are inclined to the central six-membered ring by 13.68 (9) and 9.13 (8)°, respectively, and to one another by 21.95 (9)°. In the crystal, molecules are linked by O—H...O hydrogen bonds, forming helical chains along [010].
Two tautomers in the same crystal: 3-(4-fluorophenyl)-1H-pyrazole and 5-(4-fluorophenyl)-1H-pyrazole
Authors: Yamuna Thammarse S. , Kaur Manpreet , Jasinski Jerry P. , Anderson Brian J. , Yathirajan H. S.
Published: August 2014

The title co-crystal, 3-(4-fluorophenyl)-1H-pyrazole–5-(4-fluorophenyl)-1H-pyrazole (1/1), C9H7FN2, crystallizes with four independent molecules (A,B,CandD) in the asymmetric unit exhibiting two tautomeric forms (AandD;BandC) due to N—H proton exchange between the two N atoms of the pyrazole ring. The dihedral angles between the mean planes of the pyrazole and benzene rings are 15.6 (1), 19.8 (9), 14.0 (1) and 10.7 (7)° in moleculesA,B,CandD, respectively. In the crystal, N—H...N hydrogen bonds link the four molecules in the asymmetric unit into a ring with anR44(12) motif. Furthermore, weak C—H...F interactions link the molecules into a three-dimensional network.
HAUSP compartmentalization in chronic myeloid leukemia
Authors: Morotti Alessandro , Panuzzo Cristina , Crivellaro Sabrina , Carrà Giovanna , Guerrasio Angelo , Saglio Giuseppe
Published: August 2014

Introduction

PTEN plays an essential role in the pathogenesis of chronic myeloid leukemia. Recently, we have shown that BCR‐ABL promotes PTEN nuclear exclusion, through the modulation of HAUSP activity.

Objectives

Here, we investigate HAUSP cellular compartmentalization in primary CML samples.

Results

While in normal CD34 positive cells HAUSP is expressed mostly in the nucleus, in CML CD34 cells HAUSP is expressed both in the nuclear bodies and in the cytoplasm.

Conclusions

This observation suggests that HAUSP behaves as a shuttling protein in CML. It can bind to BCR‐ABL in the cytosol, where it is phosphorylated on tyrosine residues, and it maintains the proper compartmentalization in the nuclear bodies, where it acts as part of a PML network to regulate PTEN de‐ubiquitination.
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase‐2 study (NordCML006)
Authors: Hjorth‐Hansen Henrik , Stenke Leif , Söderlund Stina , Dreimane Arta , Ehrencrona Hans , Gedde‐Dahl Tobias , Gjertsen Bjørn Tore , Höglund Martin , Koskenvesa Perttu , Lotfi Kourosh , Majeed Waleed , Markevärn Berit , Ohm Lotta , Olsson‐Strömberg Ulla , Remes Kari , Suominen Merja , Simonsson Bengt , Porkka Kimmo , Mustjoki Satu , Richter Johan ,   the Nordic CML Study Group (NCMLSG)
Published: August 2014

We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention‐to‐treat analysis with 36 months follow‐up. Early cytogenetic and molecular responses were superior in the dasatinib group, with a tendency that imatinib patients caught up with time. For instance, MR3.0 was reached at 3 months in 36% vs. 8% (P = 0.02), at 12 months in 81% vs. 46% (P = 0.02) and at 18 months in 73% vs. 65% (n.s.) of the patients in the two groups. In contrast, MR4.5 was consistently superior in the dasatinib group at all time points from 6 months onwards, reaching 61% vs. 21% (P < 0.05) at 36 months. Sixty‐four vs. 71% of the patients in the dasatinib and imatinib arms, respectively, remained on assigned drug. Dasatinib dose was frequently reduced, but with maintained excellent effect. One imatinib patient progressed to blastic phase, but no CML‐related deaths occurred. In conclusion, our data compare favourably with those of the dasatinib registration study, DASISION. The fast and deep molecular responses induced by dasatinib compared with imatinib may be exploited to increase the proportion of patients who can achieve a treatment‐free remission after treatment discontinuation.
Comparative growth and metabolism of gelatinous colonies of three cyanobacteria, Nostoc commune, Nostoc pruniforme and Nostoc zetterstedtii, at different temperatures
Authors: Møller Claus Lindskov , Vangsøe Marie Therese , Sand‐Jensen Kaj
Published: August 2014

The cyanobacterial genus Nostoc includes several species forming large spherical or sheet‐like gelatinous colonies of ecological importance in freshwater and semi‐terrestrial habitats. We tested differences in morphology, growth and metabolism across a range of temperatures (6–43 °C) of three colonial species of Nostoc collected and grown in ambient water from typical localities from Denmark and Sweden: the plume‐shaped Nostoc pruniforme, the rare blackberry‐shaped Nostoc zetterstedtii and the semi‐terrestrial, sheet‐like Nostoc commune.

All three species grew and photosynthesised in water between 6 and 33 °C in our experiments but died at 43 °C. The optimum temperature of around 25 °C and the critical temperature of around 33 °C are markedly higher than mean and maximum temperatures in the majority of habitats of N. pruniforme and N. zetterstedtii, suggesting that their distribution does not reflect temperature preference directly. Although N. commune survives deep‐freezing and heating to 70 °C, sustained growth was restricted to 0–33 °C.

Maximum growth rates were relatively high for N. pruniforme and N. commune (doubling time of 13–15 days) and extremely low for N. zetterstedtii (doubling time of 2.4 years). Rates of photosynthesis, respiration and growth were markedly higher in alkaline water than in softwater, but N. pruniforme still grew much faster than N. zetterstedtii in the same water. Declines of growth and photosynthetic rates with increasing ratio of dry weight to surface area between the species and with increasing colony size reflect higher respiratory costs relative to resource uptake.

We conclude that the three Nostoc species have similar temperature tolerance from 6 to 43 °C, despite large interspecific differences in rates of growth and photosynthesis, colony persistence and distribution.
Diagnoses of 964 oral biopsies from people aged over 50 years in Karnataka State, India
Authors: Mohan Bhavna C. , Angadi Punnya V. , Hallikerimath Seema , Kale Alka D.
Published: August 2014

Introduction

The drastic epidemiological transition has created a huge void in evidence with regard to the health statistics of elderly population. Data are sparse on the oral mucosal conditions prevalent among the elderly Indian population. This study aimed to review the oral biopsies reported in the institute over the last 21 years and to examine the trends in geriatric oral pathologies.

Methodology

A total of 964 histologically confirmed geriatric (age ranging 50–97 years) oral lesions among 4000 cases reported were retrieved from the files of Department of Oral Pathology and Microbiology of KLE VK institute, Belgaum, Karnataka commencing since 1992 till 2012. These cases were retrospectively evaluated for various parameters such as age, gender, duration, location and type of lesions.

Results

The geriatric oral lesions were seen to occur predominantly in men (65%), especially the sixth decade of life (47%). The most common location was the buccal mucosa (29%). The malignant neoplastic lesions accounted for the majority of the geriatric lesions (36%) followed by non‐neoplastic lesions (27%), potentially malignant disorders (26%) and benign neoplasms, which formed a minor proportion of (11%). The oral squamous cell carcinoma was the single most common geriatric lesion accounted. Gender and age‐wise correlation analyses among the various lesion categories showed statistical significance.

Conclusion

The study provides valuable information about major oral pathologies in our scenario that contribute to significant morbidity and mortality among the geriatric population. It also sheds light about the diseases that need to be targeted in future Indian public health policies and initiatives for geriatric care.
Sugar replacement in sweetened bakery goods
Authors: Struck Susanne , Jaros Doris , Brennan Charles S. , Rohm Harald
Published: August 2014

This review presents the state‐of‐the‐art concerning the application of natural and artificial high‐intensity sweeteners, fructans and bulking agents such as polyols as sugar replacers in sweet‐baked goods and their effects on product characteristics. The recent much publicised attention given to weight gain of the population and its consequences on the occurrence of diet‐related diseases in developed countries has influenced the food manufacturers attempts to provide the consumer with reduced energy products. The replacement of sucrose in sweet bakery products by alternative natural or artificial sweeteners can be a challenging issue. Sucrose as a main ingredient in sweet bakery products contributes, aside from providing sweetness, to numerous processing and product characteristics. Intense sweeteners have a high sweetness compared with sucrose but lack in their contribution to the body of the product, whereas the replacement of sucrose with bulking sweeteners may result in products with a similar body but a lack in taste and flavour.
The changing place of liver biopsy in clinical practice: an audit of an Australian tertiary hospital
Authors: Varma P. , Jayasekera C. , Gibson R. N. , Stella D. L. , Nicoll A. J.
Published: August 2014

Liver biopsy is an important tool in hepatology, with a role now generally limited to cases of diagnostic uncertainty. A retrospective audit performed at the Royal Melbourne Hospital aimed to identify the indications for liver biopsy and its impact on management. Ten per cent (20/195) of biopsies lacked a strong clinical indication, with hepatology involvement in only 8/20. We recommend prior hepatologist assessment to minimise unnecessary biopsies.
Travail à temps partiel, ségrégation professionnelle et égalité entre hommes et femmes en Europe
Authors: SPARREBOOM Theo
Published: August 2014

L'auteur montre comment la ségrégation sexuelle et la ségrégation en fonction de la durée du travail modèlent l'espace professionnel des travailleurs à temps partiel. La première varie selon les parts du plein temps et du temps partiel dans l'emploi total. Le compromis entre volume de l'emploi féminin et ségrégation sexuelle est plus prégnant pour le plein temps. La ségrégation sexuelle est moins marquée dans l'emploi à temps partiel que dans l'emploi à plein temps, et l'écart entre le volume de l'emploi à temps partiel masculin et celui de l'emploi à temps partiel féminin détermine les effets du travail à temps partiel sur la ségrégation dans l'emploi total.
Effective population size and inbreeding depression on litter size in rabbits. A case study
Authors: Ragab M. , Sánchez J.P. , Baselga M.
Published: August 2014

The purpose of this study is to use demographic and litter size data on four Spanish maternal lines of rabbits (A, V, H and LP), as a case study, in order to: (i) estimate the effective population size of the lines, as a measure of the rate of increase of inbreeding, and (ii) study whether the inbreeding effect on litter size traits depends on the pattern of its accumulation over time. The lines are being selected for litter size at weaning and are kept closed at the same selection nucleus under the same selection and management programme. The study considered 47 794 l and a pedigree of 14 622 animals. Some practices in mating and selection management allow an increase of the inbreeding coefficient lower than 0.01 per generation in these lines of around 25 males and 125 females. Their effective population size (Ne) was around 57.3, showing that the effect of selection, increasing the inbreeding, was counterbalanced by the management practices, intended to reduce the rate of inbreeding increase. The inbreeding of each individual was broken down into three components: old, intermediate and new inbreeding. The coefficients of regression of the old, intermediate and new inbreeding on total born (TB), number born alive (NBA) and number weaned (NW) per litter showed a decreasing trend from positive to negative values. Regression coefficients significantly different from zero were those for the old inbreeding on TB (6.79 ± 2.37) and NBA (5.92 ± 2.37). The contrast between the coefficients of regression between the old and new inbreeding were significant for the three litter size traits: 7.57 ± 1.72 for TB; 6.66 ± 1.73 for NBA and 5.13 ± 1.67 for NW. These results have been interpreted as the combined action of purging unfavourable genes and artificial selection favoured by the inbreeding throughout the generations of selection.