bluuebunny/crossref_metadata_2025 huggingface dataset:
Odyssey: A Journey in the Land of Distributed Data Series Similarity Search
Authors: Chatzakis Manos , Fatourou Panagiota , Kosmas Eleftherios , Palpanas Themis , Peng Botao
Published: March 2023

This paper presents Odyssey, a novel
distributed
data-series processing framework that efficiently addresses the critical challenges of exhibiting good speedup and ensuring high scalability in data series processing by taking advantage of the full computational capacity of modern distributed systems comprised of multi-core servers. Odyssey addresses a number of challenges in designing efficient and highly-scalable
distributed
data series index, including efficient scheduling, and load-balancing without paying the prohibitive cost of moving data around. It also supports a flexible partial replication scheme, which enables Odyssey to navigate through a fundamental trade-off between data scalability and good performance during query answering. Through a wide range of configurations and using several real and synthetic datasets, our experimental analysis demonstrates that Odyssey achieves its challenging goals.
The Clinical Characterization of Blocking Tics in Patients With Tourette Syndrome
Authors: Baizabal-Carvallo José Fidel , Jankovic Joseph
Published: March 2023

Objective Tourette syndrome (TS) is a neurodevelopmental disorder characterized by the presence of motor and phonic tics. Blocking phenomena, characterized by arrests in motor activity causing interruptions in movements or speech, have also been described in patients with TS. In this study, we aimed to characterize the frequency and features of blocking tics in patients with TS.Methods We studied a cohort of 201 patients with TS evaluated at our movement disorders clinic.Results We identified 12 (6%) patients with blocking phenomena. Phonic tic intrusion causing speech arrest was the most common (n = 8, 4%), followed by sustained isometric muscle contractions arresting body movements (n = 4, 2%). The following variables were statistically related to blocking phenomena: shoulder tics, leg tics, copropraxia, dystonic tics, simple phonic tics, and number of phonic tics per patient (all p < 0.050). In the multivariate regression, the presence of dystonic tics (p = 0.014) and a higher number of phonic tics (p = 0.022) were associated with blocking phenomena.Conclusion Blocking phenomena are present in approximately 6% of patients with TS, and the presence of dystonic tics and a higher frequency and number of phonic tics increase the risk for these phenomena.
Is There a Business Cycle Effect on the Incidence of Dual Job Holding?
Authors: Renna Francesco , Oaxaca Ronald L. , Choe Chung
Published: March 2023

This paper examines the extent to which the incidence of dual job holding is cyclically sensitive in the context of hours constraints on a worker’s weekly labor supply to their main job. Random effects logit models of the probability of dual job holding are estimated separately for men and women for each of three mutually exclusive, hours-constrained regimes: overemployment, unconstrained hours, and underemployment. As measured by the deviation of each individual’s current regional unemployment rate from their time-averaged mean regional unemployment rate, transitory business cycle movements have no effect on the probability of dual job holding. However, a permanent/steady-state increase (decrease) in the local unemployment rate reduces (raises) the probability of dual job holding among hours-unconstrained workers for both males and females. Furthermore, permanent employment contracts reduce the likelihood of having two jobs.
Performance of photocatalytic oxidation surface with new geometry for indoor environment application: experimental and simulation
Authors: Khoshpasand Fatemeh , Nikpay Ahmad , Keshavarz Mehrdad
Published: March 2023

Many studies of the photocatalytic oxidation process investigated on the removal efficiency and other variables of the input and output photoreactor. In the laboratory scale, it’s impossible, examination of the removal efficiency details, such as mass and energy transfer with air flow rate. Also, experimental methods request time consumption and money. For this reason, the simulation method can be used. The aim of this study was to prove that the validation of modeling approach in the photocatalytic oxidation process in the removal of toluene from air. Investigation of bed surface morphology, with FESEM, BET and TGA, shows acceptable monotonous of TiO2 nanoparticles on the ss plate. Furthermore, it was observed good adherence of nanoparticles on it. Experimental results on photocatalytic bed surface exhibited in the toluene concentration range of 10–40 ppm and flow rate of 2–5 l/min, with increasing flow and decreasing concentration, removal efficiency increased. The optimum removal point was 59% and 25 g/m3 min for 3.75 ppm and 5.61 l/min. For bed surface performance, the correlation between experimental results and simulation data was obtained 98%. According to the results, the photocatalytic oxidation process performed well for removal of low concentration of toluene from air. In addition, the obtained simulation method eliminated the random factors which can be affected by photocatalytic bed surface and it can show dependence of results based on reality.
WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients
Authors: Zhao Ruipeng , Wei Wan , Zhen Linlin
Published: March 2023

Locally advanced breast cancer patients have a poor prognosis; however, the relationship between potential targets and the response to treatment is still unclear. The gene expression profiles of breast cancer patients with stages from IIB to IIIC were downloaded from The Cancer Genome Atlas. We applied weighted gene co-expression network analysis and differentially expressed gene analysis to identify the primary genes involved in treatment response. The disease-free survival between low- and high-expression groups was analyzed using Kaplan–Meier analysis. Gene set enrichment analysis was applied to identify hub genes-related pathways. Additionally, the CIBERSORT algorithm was employed to evaluate the correlation between the hub gene expression and immune cell types. A total of 16 genes were identified to be related to radiotherapy response, and low expression of SVOPL, EDAR, GSTA1, and ABCA13 was associated with poor overall survival and progression-free survival in breast cancer cases. Correlation analysis revealed that the four genes negatively related to some specific immune cell types. The four genes were downregulated in H group compared with the L group. Four hub genes associated with the immune cell infiltration of breast cancer were identified; these genes might be used as a promising biomarker to test the treatment in breast cancer patients.
STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy
Authors: Wan Wei , Qian Chuying , Wang Qian , Li Jin , Zhang Hongtao , Wang Lei , Pu Maomao , Huang Yewei , He Zhengfu , Zhou Tianhua , Shen Han‐Ming , Liu Wei
Published: March 2023

The cGAS‐STING pathway plays an important role in host defense by sensing pathogen DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of autophagosome formation in cGAS‐STING pathway‐induced autophagy is still unclear. Here, we report that STING directly interacts with WIPI2, which is the key protein for LC3 lipidation in autophagy. Binding to WIPI2 is necessary for STING‐induced autophagosome formation but does not affect STING activation and intracellular trafficking. In addition, the specific interaction between STING and the PI3P‐binding motif of WIPI2 leads to the competition of WIPI2 binding between STING and PI3P, and mutual inhibition between STING‐induced autophagy and canonical PI3P‐dependent autophagy. Furthermore, we show that the STING‐WIPI2 interaction is required for the clearance of cytoplasmic DNA and the attenuation of cGAS‐STING signaling. Thus, the direct interaction between STING and WIPI2 enables STING to bypass the canonical upstream machinery to induce LC3 lipidation and autophagosome formation.
Modeling mitochondrial DNA diseases: from base editing to pluripotent stem‐cell‐derived organoids
Authors: Tolle Isabella , Tiranti Valeria , Prigione Alessandro
Published: March 2023

Mitochondrial DNA (mtDNA) diseases are multi‐systemic disorders caused by mutations affecting a fraction or the entirety of mtDNA copies. Currently, there are no approved therapies for the majority of mtDNA diseases. Challenges associated with engineering mtDNA have in fact hindered the study of mtDNA defects. Despite these difficulties, it has been possible to develop valuable cellular and animal models of mtDNA diseases. Here, we describe recent advances in base editing of mtDNA and the generation of three‐dimensional organoids from patient‐derived human‐induced pluripotent stem cells (iPSCs). Together with already available modeling tools, the combination of these novel technologies could allow determining the impact of specific mtDNA mutations in distinct human cell types and might help uncover how mtDNA mutation load segregates during tissue organization. iPSC‐derived organoids could also represent a platform for the identification of treatment strategies and for probing the in vitro effectiveness of mtDNA gene therapies. These studies have the potential to increase our mechanistic understanding of mtDNA diseases and may open the way to highly needed and personalized therapeutic interventions.
SARS‐CoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19
Authors: Temmam Sarah , Montagutelli Xavier , Herate Cécile , Donati Flora , Regnault Béatrice , Attia Mikael , Baquero Salazar Eduard , Chretien Delphine , Conquet Laurine , Jouvion Grégory , Pipoli Da Fonseca Juliana , Cokelaer Thomas , Amara Faustine , Relouzat Francis , Naninck Thibaut , Lemaitre Julien , Derreudre‐Bosquet Nathalie , Pascal Quentin , Bonomi Massimiliano , Bigot Thomas , Munier Sandie , Rey Felix A , Le Grand Roger , van der Werf Sylvie , Eloit Marc
Published: March 2023

Bat sarbecovirus BANAL‐236 is highly related to SARS‐CoV‐2 and infects human cells, albeit lacking the furin cleavage site in its spike protein. BANAL‐236 replicates efficiently and pauci‐symptomatically in humanized mice and in macaques, where its tropism is enteric, strongly differing from that of SARS‐CoV‐2. BANAL‐236 infection leads to protection against superinfection by a virulent strain. We find no evidence of antibodies recognizing bat sarbecoviruses in populations in close contact with bats in which the virus was identified, indicating that such spillover infections, if they occur, are rare. Six passages in humanized mice or in human intestinal cells, mimicking putative early spillover events, select adaptive mutations without appearance of a furin cleavage site and no change in virulence. Therefore, acquisition of a furin site in the spike protein is likely a pre‐spillover event that did not occur upon replication of a SARS‐CoV‐2‐like bat virus in humans or other animals. Other hypotheses regarding the origin of the SARS‐CoV‐2 should therefore be evaluated, including the presence of sarbecoviruses carrying a spike with a furin cleavage site in bats.
Reconstruction of E-Court Legal Culture in Civil Law Enforcement
Authors: Latifiani Dian , Yusriyadi Yusriyadi , Sarono Agus , Al Fikry Ahmad Habib , Cholis Mohammad Nur
Published: March 2023

Legal protection for the community to obtain rights and recovery of the situation is one of them taken by settling civil cases through the courts. During the times and the adjustment of existing conditions, the Supreme Court issued a responsive and progressive law with the enactment of Supreme Court Regulation Number 1 of 2019 so that the public could obtain essential justice based on the principles of fast, simple, and low-cost justice. The aims of this study are: (i) knowing the legal culture in the implementation of e-court as a reflection of the problems of law enforcement; and (ii) reconstruction of legal culture regarding case administration and court proceedings electronically. The author uses empirical juridical research methods. The results of the study show: (i) e-court based court legal culture is not yet optimal. Village communities seeking justice (non-advocates) at the Religious Courts and District Courts of Semarang Regency tend to prefer conventional registration and trial over e-courts; and (ii) the reconstruction of the legal culture community is carried out using e-court socialization education to all advocates, providing educational media to non-advocates, and providing information about administration and trials electronically through notification letters to the district head .Through this, it will create a legal culture that supports the implementation of e-court so that fair law enforcement can be achieved.
Significados parciales del teorema de Pitágoras usados por docentes en la creación de tareas en el marco de un programa de formación continua
Authors: Calle Eulalia , Breda Adriana , Font Vicenç
Published: March 2023

[Objetivo] El objetivo de este artículo es presentar resultados de una investigación sobre la enseñanza y el aprendizaje del criterio “implementar una muestra representativa de la complejidad del objeto matemático que se quiere enseñar”, implementado con profesorado de secundaria de matemáticas de Ecuador en un máster de formación continua. [Metodología] Después de explicar el proceso de instrucción en el que se enseñó este criterio, se presenta el análisis cualitativo de las respuestas a una de las tareas que se propuso al alumnado de este máster: crear tareas en las que, para su resolución, se tenía que aplicar un determinado significado parcial del teorema de Pitágoras (el geométrico o el aritmético-algebraico), como ejemplo de evidencia del aprendizaje conseguido. [Resultados] Los resultados muestran que algunos alumnos del máster proponen tareas para trabajar el teorema de Pitágoras, pero no especifican ni justifican si las tareas diseñadas por ellos están relacionadas con el significado aritmético-algebraico, con el geométrico o con ambos; otros no propusieron ninguna tarea para trabajar el significado aritmético-algebraico y un participante del máster no propuso ninguna tarea para trabajar el significado geométrico. También se observa que algunos crearon tareas que no se corresponden con el significado que señalan. [Conclusiones] Se concluye que los profesores tienen dificultades para crear una tarea y señalar el tipo del significado del teorema de Pitágoras que se debe usar para resolverla y que el significado geométrico es el que mejor relacionan con la tarea que proponen.
Tipología de las preguntas sobre variabilidad en los textos escolares y su relación con la alfabetización y pensamiento estadístico
Authors: Rodríguez-Alveal Francisco , Maldonado-Fuentes Ana C
Published: March 2023

[Objetivo] El presente estudio tiene como propósito analizar si las preguntas relacionadas con el concepto de variabilidad que se presentan en los textos escolares de enseñanza secundaria en Chile permiten alfabetizar y pensar estadísticamente a los estudiantes del sistema escolar. [Metodología] Para tal efecto se hizo uso de un enfoque cualitativo mediante un análisis de contenido de los libros de textos de enseñanza secundaria publicados en los años 2016-2018-2020 y 2021. Las unidades de análisis fueron seleccionadas mediante un muestreo no probabilístico del tipo intencionado. [Resultados] Entre los hallazgos más relevantes se puede señalar que gran parte de las preguntas de los libros de texto analizados hacen uso de pronombres interrogativos qué y cuál. En estos casos, la interrogante se asocia a interpelaciones de bajo nivel cognitivo destinadas esencialmente al cálculo de estadígrafos de variabilidad, sin hacer uso de herramientas tecnología. Por el contrario, las preguntas afines a niveles cognitivos superiores como leer, analizar y tomar decisiones evidencian baja representatividad dentro de los casos observados. El concepto variabilidad se relaciona de manera fundamental con la noción de dispersión, lo cual ha sido cuestionado por investigadores de habla inglesa. [Conclusiones] En síntesis, los resultados sugieren que es recomendable que los profesores del sistema escolar orienten, reformulen y diseñen preguntas afines al concepto de variabilidad tomando como base las preguntas clasificadas en categorías superiores tales como análisis, argumentación y evaluación de manera que el estudiantado desarrolle una alfabetización y pensamiento estadístico
Traducción e ideología
Authors: Arduini Stefano
Published: March 2023

En este trabajo se estudia la relación que tiene la traducción con la ideología. Partiendo de una aproximación a la definición de ideología nos acercamos a los límites en los que opera la cultura en el proceso de traducción y de la relación entre el lenguaje y el mundo.
Teoría de los modelos de mundo y teoría de los mundos posibles
Authors: Asensi Pérez Manuel
Published: March 2023

El presente texto trata de delimitar las diferencias entre la teoría de los modelos de mundo, elaborada por el autor en su libro Crítica y sabotaje(2011), y la teoría de los mundos posibles que autores como Petöfi, Doležel o Albaladejo pusieron en marcha entre finales de los años 70 y los 90. La tesis central que se sostiene es que mientras la teoría de los mundos posibles sitúa la referencia del texto fuera del mundo, en un mundo posible, la teoría de los modelos de mundo mantiene la referencia del texto centrada en el “mundo”. Tal y como se pone de relieve a lo largo de estas páginas, la teoría de los mundos posibles es deudora de la ideología estética, mientras que la teoría de los modelos de mundo surge a partir de una posición crítica con dicha ideología.
Epidemiology of Platelet Transfusions in Hospitalized Children: A Pediatric Hospital Information System Database Study
Authors: Lang Emily A. , An Anjile , Finn Sarah , Prishtina Fisnik , DeSimone Robert A. , Nellis Marianne E.
Published: March 2023

OBJECTIVES

To describe the epidemiology and complications of platelet transfusions among hospitalized pediatric patients during 2010 to 2019.

METHODS

We performed a retrospective cohort study of hospitalized children within the Pediatric Health Information System database. Pediatric encounters receiving at least one platelet transfusion during hospitalization from 2010 to 2019 were identified. Data regarding demographics, diagnoses, procedures required during hospitalization, complications, and outcomes were extracted for eligible encounters.

RESULTS

Within the Pediatric Health Information System database, 6 284 264 hospitalizations occurred from 2010 to 2019. A total of 244 464 hospitalizations required at least one platelet transfusion, yielding a prevalence of 3.89% (95% confidence interval [CI], 3.87%–3.91%). Transfusion prevalence did not change significantly across the decade (P value = .152). Two-thirds of children receiving platelet transfusions were in their first 6 years of life, and the majority identified as male (55%). Recipients most commonly had diseases of the circulatory system (21%, 52 008 of 244 979), perinatal disorders (16%, 38 054 of 244 979), or diseases of the hematologic/immune systems (15%, 37 466 of 244 979). When adjusted for age, support by extracorporeal membrane oxygenation, mechanical ventilation, surgical intervention, and diagnostic category, the odds of thrombosis, infection, and mortality increased by 2% (odds ratio [OR], 1.02; 95% CI, 1.016–1.020), 3% (OR, 1.03; 95% CI, 1.028–1.033), and 7% (OR, 1.07; 95% CI, 1.067–1.071), respectively, with each additional transfusion.

CONCLUSIONS

The prevalence of platelet transfusions among pediatric inpatients remained consistent across the decade. Our finding that increasing numbers of transfusions may be associated with elevated morbidity and mortality is consistent with other observation and experimental studies, highlighting the need to be thoughtful in weighing risks and benefits when prescribing repeated platelet transfusions to hospitalized children.
¿Existe(n) una(s) nueva(s) derecha(s) en Chile?
Authors: Bustamante Olguín Fabián
Published: March 2023

El propósito de este artículo es hacer una reflexión teórica contingente acerca de si  la “nueva derecha” que está emergiendo en la actualidad es radical o simplemente una continuación de la derecha chicago gremialista que ha sido hegemónica en estos últimos años en la historia política reciente en Chile. Para discutir los límites de las derechas, sus particularidades y aspectos analíticos, se utiliza una bibliografía especializada sobre las derechas en Chile y en el extranjero. En este artículo sugerimos que las derechas se caracterizaron por la hibridación ideológica, cuya característica axial es la co-presencia o integración dialéctica de una amplia gama de discursos de diferentes tradiciones ideológicas y de pensamiento. Al final de este escrito, se hipotetiza la posibilidad de emergencia de una derecha nacionalista mesocrática y popular comprometida con una integración nacional basada en ideales republicanos, y una derecha radical xenófoba, que fomente la adhesión a valores de exclusión ante la llegada de inmigrantes en los últimos años en Chile.
Eduardo Schiaffino: un pintor en la configuración de la historia del arte y la gestión de museos en Argentina
Authors: Lo Russo Alejo
Published: March 2023

Eduardo Schiaffino, pintor con una formación de taller en Buenos Aires y en París, no solo dio forma a nuevas inserciones laborales en el medio artístico local, sino que debió legitimar su accionar y perspectivas personales. Tan ponderado como cuestionado en vida, su figura fue recuperada en la historiografía desde la década de 1990, cuando se destacó su rol en el proceso de desarrollo del ámbito artístico en Argentina entre las últimas décadas del siglo XIX y las primeras del XX. Nos proponemos en este artículo indagar en los modos en que recurrió a sus fortalezas como pintor y como teórico autodidacta para inaugurar espacios, como la historia del arte o la gestión de museos, en un campo artístico en formación y, al mismo tiempo, legitimar su acción.
Teatro, trabajo y afectos en las compañías-familias argentinas de los Podestá durante finales del siglo XIX y principios del XX
Authors: Noguera Lía Sabrina
Published: March 2023

La familia fundadora, en lo que refiere a la actividad teatral en Argentina, es la de los Podestá. Su árbol genealógico alberga más de cien miembros (la mayoría artistas) y abarca el arco temporal desde fines del siglo XIX al siglo XX. En el presente artículo, nos concentramos en el estudio de aquello que hemos denominado ‘compañías-familias’, categoría que responde y evidencia los vínculos de sangre establecidos entre sus integrantes y los contratos matrimoniales producidos también con artistas del campo artístico local. A partir de un estudio que contempla las condiciones estéticas, laborales y la incidencia de los vínculos afectivos, tanto para sus formaciones como para sus rupturas, nos enfocamos en el análisis de las compañías-familias formadas en Buenos Aires por Jerónimo Podestá y Pablo Podestá entre 1880 y 1920.
Enhancement of aromatic and sensory profile of jujube wines fermented with fresh Zizyphus jujuba cv. Muzao at the white-ripe period
Authors: Wang J. , Zhang W.J. , Wang N.N.
Published: March 2023

In this paper, fresh Muzao (Zizyphus jujuba cv. Muzao) at full-red and white-ripe periods were used as raw materials to brew low-alcohol jujube wines directly without cooking or extraction. The results showed that the contents of total acid, total phenolics, and total tannin of white-ripe jujube wines (WRJW) were significantly higher than that of full-red jujube wines (FRJW) under the same ratio of jujube fruit/water (P < 0.05). When the ratio of jujube fruit to water increased from 1:1 to 1:5, the total esters contents of WRJW increased from 2261.56 μg L−1 to 3671.51 μg L−1, but decreased in FRJW. Especially, the contents of ethyl octanoate, ethyl decanoate, and isoamyl caprylate in WRJW (1:5) were significantly higher than in other wine samples (P < 0.05). These three esters with a variety of aroma description characteristics can give jujube wine a more complex flavour. The sensory evaluation also showed that the WRJW (1:5) had the highest score. This wine had the following characteristics: clear and transparent, light yellow, pure elegant fruit and wine aroma, pleasant fragrance, harmonious wine body, fresh taste, sweet and sour, with typical characteristics of jujube wine. The research results can provide a theoretical basis and technical reference for the industrial production of high-quality jujube wine.
Phase formation of cubic silicon carbide from reactive silicon–carbon multilayers
Authors: Shekhawat Deepshikha , Sudhahar Dwarakesh , Döll Joachim , Grieseler Rolf , Pezoldt Jörg
Published: March 2023

Silicon carbide layers were fabricated using self-propagating high-temperature synthesis of binary silicon-carbon based reactive multilayers. The silicon and carbon bilayers were fabricated with two different bilayer thicknesses. They are deposited by magnetron sputtering in an alternating layer system with a total thickness of 1 μm. The entire system is annealed by rapid thermal annealing at different temperatures ranging from 500 to 1100 °C. From XRD analysis we could find that the formation of the silicon carbide phase was initiated from 700 °C. With increasing bilayer thickness the silicon carbide phase formation was partially suppressed by the silicon recrystallization due to resulting lower carbon diffusion into silicon. The transformation process proceeds in a four-step process: densification/recrystallization, interdiffusion, nucleation and transformation. From this, it was noted that when compared to low bilayer thickness samples, the formation of the silicon carbide phase is delayed with increasing bilayer thickness and needs higher reaction initiation temperatures.

Graphical abstract
SIRT3 improves alveolar epithelial cell damage caused by bronchopulmonary dysplasia through deacetylation of FOXO1
Authors: Zang Lili , Chi Jinghan , Bi Sitong , Tao Yi , Wang Rong , Li Lihua
Published: March 2023

Background: Bronchopulmonary dysplasia (BPD) is a serious and long-term lung condition commonly observed in premature babies. Sirtuin 3 (SIRT3) has been reported to reduce pulmonary injury and pulmonary fibrosis.
Objective: The present study investigated the specific role of SIRT3 in BPD by establishing hyperoxia-induced BPD rat and cell models. Hematoxylin and eosin staining was used to observe pathological changes in lung tissues.
Materials and methods: The expression levels of SIRT3 and forkhead box protein O1 (FOXO1), as well as its acetylation levels, were detected in hyperoxia-induced lung tissues and cells by Western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Levels of reactive oxygen species, superoxide dismutase, and malondialdehyde were assessed by using biochemical kits. Following SIRT3 overexpression, the levels of inflammatory cytokines were assessed by RT-qPCR. Apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nickend labeling (TUNEL) and Western blot analysis. Upon FOXO1 knockout, cell inflammation, oxidative stress and apoptosis were evaluated again.
Results: Compared to the control group, the SIRT3 and FOXO1 expression levels were decreased and the FOXO1 acetylation levels were increased in hyperoxia-induced lung tissues and cells. In addition, SIRT3 reduced hyperoxia-induced inflammation, oxidative stress, and apoptosis in A549 cells, and inhibited FOXO1 acetylation to activate FOXO1. However, FOXO1 knockdown reversed the effects of SIRT3 overexpression in hyperoxia-induced A549 cells.
Conclusion: SIRT3 relieved alveolar epithelial cell damage caused by BPD via deacetylation of FOXO1, suggesting that SIRT3 could be a therapeutic target in BPD.
A case of persistent IgE sensitisation almost two decades following ampicillin anaphylaxis
Authors: Au Elaine YL , Chiang Valerie , Chun Kan Andy Ka , Lam Ki , Wong Jane CY , Yeung Heather HY , Li Philip Hei
Published: March 2023

Background: Although most immunoglobulin E (IgE)-mediated penicillin allergy wanes with time, sensitisation may occasionally persist for many years. Previous reports on the loss of penicillin-specific IgE sensitisation were based on non-anaphylaxis cases and, although uncommon, persistent sensitisation may still be possible in the minority of cases.
Objective: This case highlights that irrespective of the elapsed duration since the index reaction, it is important to remain vigilant when approaching patients with a history of severe reactions.
Material and Methods: We described a case of persistent IgE sensitisation almost two decades following ampicillin anaphylaxis.
Results: A 78-year-old male with a history of perioperative penicillin anaphylaxis in 2003 was referred for allergy workup in 2022 before his knee joint replacement surgery. The patient had strictly avoided all beta-lactams since the index reaction. However, his penicillin-specific sensitisation persisted, evidenced by positive skin tests (with generalised urticaria after intradermal testing) and basophil activation tests.
Conclusion: To our knowledge, this was the first case of positive BAT tested around two decades following the index reaction. This case illustrates that a cautious approach may still be warranted in patients with a history of severe reaction to penicillin regardless of the duration since the reported index reaction.
Real-life data on the effectiveness of extensively hydrolyzed protein-based formula and amino acid–based formula in regaining weight and height in infants on a cow’s milk protein elimination diet
Authors: Batista de Faria Dayane Pêdra , Duarte de Sillos Marcela , Leite Speridião Patrícia da Graça , De Morais Mauro Batista
Published: March 2023

Objective: To compare the effectiveness of extensively hydrolyzed protein-based formula (EHF) or amino acid–based formula (AAF) in reversing the weight and height deficit in infants on a cow’s milk protein elimination diet.
Methods: Infants from a retrospective cohort who were fed EHF (n = 17) or AAF (n = 16) for at least 2 months on a cow’s milk protein elimination diet were included. The weight and height values recorded in the infants’ medical records were obtained.
Results: The mean age of the infants at the start of EHF and AAF were 5.8 ± 2.6 and 4.4 ± 2.5 months, respectively (P = 0.061). There was no difference between the groups in terms of the monthly weight gain (373.0 ± 212.2 and 453.1 ± 138.5 g, P = 0.223, respectively, for EHF and AAF), while the monthly increase in height was greater in the group fed with AAF (1.3 ± 0.5 and 1.8 ± 0.6, P = 0.030). A comparison between the difference in the initial z-score and in the oral challenge test of weight-for-age (+0.7 ± 1.2 and +1.3 ± 1.4, P = 0.262, respectively, for the EHF and AAF groups), height-for-age (+0.2 ± 1.1 and +1.2 ± 1.8, P = 0.090), and body mass index (BMI)-for-age (+0.7 ± 1.3 and +0.7 ± 1.5, P = 0.971) did not reveal a statistically significant difference between the groups. Correlation coefficients showed that the greater the initial nutritional deficit, the greater the positive variation between the beginning of each formula and the oral challenge test.
Conclusion: EHF and AAF provided similar increases in the weight-for-age, height-for-age, and BMI-for-age z-scores in both groups. The monthly increase in height was greater in infants who received AAF.
ESTUDO DA PERCEPÇÃO DA QUALIDADE AMBIENTAL RESIDENCIAL DOS MORADORES DE CANDELÁRIA, ZONA SUL DE NATAL/RN
Authors: Lucena Sheyla Varela , Bandeira Elaine Denise , De Souza Samir Cristino
Published: March 2023

O estudo da qualidade ambiental urbana através da percepção dos moradores expõe os problemas ambientais observados associados aos impactos dos processos de urbanização e das atividades em meio urbano, como a carência de um sistema de saneamento básico eficiente. Assim, esse estudo teve como objetivo investigar a percepção da qualidade ambiental residencial dos moradores do bairro de Candelária, a partir dos indicadores de qualidade ambiental: resíduos sólidos, abastecimento de água e esgotamento sanitário. A pesquisa configura-se como um estudo de caso com abordagem quali-quantitativa e de caráter exploratório. Os problemas ambientais urbanos foram pesquisados no nível domiciliar através da percepção da qualidade ambiental e condições de vida dos moradores do bairro de Candelária. Os resultados evidenciaram que ainda é necessário o investimento na expansão das infraestruturas de esgotamento sanitário, no abastecimento de água e no gerenciamento urbano dos resíduos sólidos, segundo a percepção desses residentes. Por fim, notou-se que os estudos que analisam a percepção ambiental são cada vez mais necessários, tendo em vista a adoção de estratégias específicas de sensibilização devido ao acesso do significado que as pessoas atribuem ao meio ambiente, sendo possível servir como embasamento no planejamento de ações voltadas para a educação ambiental. Além disso, entender alguns aspectos da relação sociedade-ambiente a partir de seus atos e percepções, pode subsidiar a criação de políticas públicas ambientais para garantir melhor qualidade de vida e sustentabilidade para os moradores.
ENTRE LEIS E PRÁTICAS: O PLANO NACIONAL DE EDUCAÇÃO E O ENSINO DE HISTÓRIA
Authors: Cordeiro Anna Gabriella de Souza , Vieira Arthur Cássio de Oliviera , Brito Max Leandro de Araújo
Published: March 2023

A elaboração do Plano Nacional de Educação brasileiro foi um processo iniciado com a promulgação da Constituição de 1934 e previsto também pela Constituição vigente desde o ano de 1988. Entretanto, o primeiro PNE só foi efetivamente homologado através da Lei nº 10.172/2001, este vigorou de 2001 a 2010. Hoje, a educação é regida pelo segundo PNE, Lei nº 13.005/2014, que propõe ações para o período que compreende os anos de 2014 a 2024. Ao considerar a importância do PNE para o ensino brasileiro, tem-se por objetivo analisar a influência que o PNE exerce sobre o Ensino de História. O PNE é uma Lei e foi analisado com base nas concepções de Lei fornecidas por Thompson (1987) e Stamatto (2012). Na relação do PNE com o Ensino de História foram identificados dois pontos diretos de intersecção, o primeiro refere-se ao fomento do ensino da história e das culturas afro-brasileira, africana e indígena, e, o segundo, à elaboração da Base Nacional Curricular Comum - BNCC.  Conclui-se que, ao buscar parecer justa, a Lei que pretendeu valorizar a história das raças subjugadas durante o processo de colonização, escondia em suas entranhas um forte teor nacionalista/retrógrado, o que confirma a existência de interesses políticos no momento em questão, considerando que o próprio PNE tem sua efetivação ameaçada pela Emenda Constitucional nº 95/2016.
Plan de egreso: herramienta del cuidado - diada con enfermedad crónica
Authors:   Universidad de Santander UDES, Campos de Aldana Maria Stella , Durán Niño Erika Yurley , Ruiz-Roa Silvia Liliana , Páez Esteban Astrid Nathalia
Published: March 2023

Introducción: La OMS reporta incremento de las enfermedades crónicas no trasmisibles, dada su complejidad, los pacientes presentan constantes hospitalizaciones, por lo cual es necesario fortalecer la competencia del cuidado de la enfermedad tanto del paciente como del cuidador en el hogar a través del programa plan de egreso. Objetivo: determinar el cambio en la competencia para el cuidado posterior a la implementación de herramienta plan de egreso para el cuidado en el hogar de la diada persona-cuidador familiar en situación de cronicidad en una institución de segundo nivel de atención. Materiales y métodos: Estudio de abordaje cuantitativo, seudo-experimental, con diseño de pruebas pre-test y pos-test, aplicando los instrumentos de “caracterización diada paciente-cuidador” y “Cuidar”. La población correspondió a 62 diadas. Muestreo no probabilístico a conveniencia. Se calculó del delta pre-post y se utilizó t-Student pareada para comparar. Resultados: el programa plan de egreso aumentó en el paciente las dimensiones de Conocimiento con un delta de 3.2 y Unicidad de 3,0 y competencia de cuidado global en 10,3; mientras que las competencias del cuidador familiar mejoraron en las dimensiones de Conocimiento con un delta de 3.34, Unicidad con delta 1.5, la dimensión de Disfrute con 1.7 y la de Reciprocidad –Relación con un delta de 1.61 para un total en la competencia de 9.2. Discusión y conclusiones: Estos hallazgos sugieren fortalecer el programa plan de egreso, durante la hospitalización y alta con el propósito de mejorar la competencia para cuidar en el hogar tanto del paciente como su cuidador familiar en situación de cronicidad.
Influence of social determinants of health in family-effectiveness
Authors:   Universidade Federal de Pelotas, Pelotas, Brazil., Lise Fernanda , Schwartz Eda , De Lima Spagnolo Lílian Moura , Stacciarini Jeanne-Marie
Published: March 2023

Introduction: The Social Determinants of Health are defined by the living conditions of the population, how they are born, grow, live, work and age, and are considered as the main responsible for the health of populations. Objective: To evaluate the influence of social determinants of health on effectiveness of family functioning. Materials and Methods: A quantitative study was carried out with 200 participants between 2017 and 2018. To assess the correlation between proximal, intermediate and distal social determinants of health and the level of effectiveness of family functioning, home visits were made to 100 families who responded the Assessment of strategies in Family Effectiveness instrument and a sociodemographic questionnaire. Data were analyzed by simple frequency, Spearman’s correlation coefficient (ρ) (p <0.05), and subjected to descriptive analysis from the perspective of systemic organization. Results: The social determinants that showed a positive correlation coefficient with the level of effectiveness of family functioning were the years of study and the fixed family income. There was a negative correlation with the main source of income (number of occupations) or source of income and the presence of other members or relatives in the family. Discussion: Investments in education can improve the family's ability to organize, solve or prevent adverse events, increase income and provide more time for family relationships and the achievement of congruence, as evidenced by other authors. Conclusions: The proximal and intermediate social determinants of health influenced the level of effectiveness of family functioning.
Bilateralizm czy multilateralizm – preferowane formy współpracy gospodarczej Indii oraz Pakistanu z Chińską Republiką Ludową
Authors:   Collegium Civitas, Iwan Jakub
Published: March 2023

India and Pakistan have adopted different paths of developing economic relations with the People’s Republic of China. New Delhi focuses on advancing economic relations with Beijing through cooperation within multilateral formats, such as Asian Infrastructure Investment Bank, while Islamabad prefers strengthening economic ties through bilateral agreements, with the China-Pakistan Economic Corridor at the forefront. This article aims to show the main causes why India and Pakistan favor different forms of economic cooperation with China. The analysis consists of the description of the economic profile of India, Pakistan, and the People’s Republic of China, as well as an outline of bilateral and multilateral projects implemented on the New Delhi-Beijing, and Islamabad-Beijing lines.
Kuryle Południowe – przekazania Japonii nie będzie
Authors: Potocka Elżbieta
Published: March 2023

The development of Russian-Japanese relations from the moment the two countries met in the eighteenth century was an arena of clashes and fights for the islands of the Sea of Okhotsk – the Kurils and Sakhalin. Russia and Japan divided them among themselves according to their political needs. At the outbreak of war in the Far East, South Sakhalin and the Kuril Islands were within the borders of Japan. The Soviet Union had been planning to change this situation for years. It did so by starting war with Japan in August 1945. The USSR occupied not only the islands promised at Yalta, but much more, namely the Southern Kurils, i.e., the islands of Iturup, Kunashir, Shikotan, and the Habomai. Japan demanded their return citing historical rights.
Generational Specificity of Socio-Political Transformation in Georgia: Between Tradition and Modernity
Authors:   Collegium Civitas, Skiert-Andrzejuk Katarzyna
Published: March 2023

The article’s purpose is to analyse the generational transformation and outline the characteristics of individual generations. Moreover, the concept of V. Papava indicating generational trends was juxtaposed. The analysis characterises the young generation of Georgians in relation to other generations. I used research methods to solve this research problem based partly on secondary sources. The basic research methods used in the article are the method of analysing existing data and the comparative method, which allowed for juxtaposing the division into generations proposed by V. Papava with the general characteristics of global generation trends. Secondary statistical data studies from the Caucasus Research Resource Center completed the other methods, allowing for a more in-depth analysis of the generations. This article is a snapshot of studies on the generational transformation of Georgian society and is part of a series of articles on the young generation of Georgians and their opinions about democracy and democratisation.
Didacticism and Morality in Azerbaijan Children’s Literature
Authors:   Baku Slavic University, Azerbaijan, Gafarova Samangul Husu
Published: March 2023

The development of children’s literature dates back to the 18th century in England. The distinctive feature of children’s literature is that it benefits from the folklore of nations. Children’s literature is diverse in content and how to properly express different concepts. Regarding this, writing and criticising children’s literature appear challenging as they have a distinctive nature. The purpose of writing children’s literature is to educate them early and nurture good values since all of them shape their characters. Although there are many significant factors to evaluate in children’s literature, age and plot are always the centres of discussion. Age is considered essential in children’s literature, meaning that it determines the way of transmitting information, the word choice, and the theme for the suitable age. When it comes to the plot, different nuances, ranging from the writer’s insight and approach and the period in the written material is produced, affect topics in children’s literature. Considering that poetic feeling in children is higher and can be compared with writers’ and poets’ creativity, reading children’s books contributes to creativity, cognitive ability, and critical thinking. Therefore, children’s literature is rich in diverse topics and genres. However, as time changes, culture and morals also shift gradually, and because of this, children are believed to lose interest in the previous children’s literature. Environmental issues, technological innovations, etc., attract their attention. The emergence and development of Azerbaijan children’s literature are directly linked to the occurrence of a national enlightenment ideology. Preserving the mother tongue and the nation’s spiritual need for education conditioned this literature’s necessity. Azerbaijan children’s literature is also rich and diverse in terms of the mentioned factors. The triggering factor which encouraged enlightened writers to write children’s books in the second half of the twentieth century was the need for national poetry books and native language textbooks. Azerbaijan children’s literature has distinctive features because Azerbaijan is a multicultural and multireligious country, leading to cultural diversity and tolerance development. In Azerbaijan children’s literature, the importance of cultural and moral values such as kindness, honesty, sincerity, etc., is depicted uniquely. In terms of this, folklore, as an integral part of children’s literature, plays a crucial role in teaching moral values and preserving cultural and artistic treasures. Different genres in children’s literature instil humane characteristics in human beings, such as generosity, kindness, etc.
Економічне становище Буджака татарсько-османської доби (XV–початок XIX ст.)
Authors:   Громадськa організація «Краєвєд», Україна, Шевченко Андрій
Published: March 2023

The article examines the main stages of the formation of the economic system of Budjak during the of its intensive settlement by Tatars and Ottomans. The main prerequisites for the formation of the economic system in the 15th–early 19th centuries are the arrival of the Tatar tribes in the region and the appearance here of Italian, Moldavian, Bulgarian trading posts, which already in the 15th century created competition for the Ottoman Empire, which led to the capture of Budjak by the Turks, who established their model of the economic system. Populating the region with Nogays and at the same time reforming trade, land, tax law, the Turks turned Budjak into a supplier of household products, wine, salt, and slaves. The main ports were Akkerman, Kiliya, Timarovo, Izmail. Economic changes also affected the Tatars, who gradually abandoned their nomadic lifestyle and became the main suppliers of food, livestock, salt to Moldova, Crimea, Turkey later, in the province of the Russian Empire. The trade and tax policies of the Crimea and the Ottoman Empire were of great importance. Despite the large number of taxes, they were not heavy and, in general, did not exceed 10% of the income of local residents. The right to trade was given to all comers, Christians and Muslims. In the 18th century, Kyrym Giray Khan developed a project for the creation of 2 commercial ports, which were supposed to supply grain to Istanbul and create competition for the ports of Turkey on the Danube. The publication reveals the role of the main ethnic groups in the economic specialization of the region. Moldovans were engaged in agriculture and wine production, Tatars – in animal husbandry, agriculture, salt mining, Turks, Ukrainians – in trade. Economic growth has strengthened the role of the Budjak ports in international trade, which has led to the interest of European states in expanding economic contacts with the region