bluuebunny/crossref_metadata_2025 huggingface dataset:
A importância da associação entre síndrome metabólica e esteatose hepática
Authors: Monteiro Elma Oliveira Alves , Toledo Aline Neves , Barbosa Gabriella de Menezes , Garate Ana Lorena Souza de Vasconcelos
Published: November 2022

Introdução: A doença hepática gordurosa não alcoólica (DHGNA), é uma entidade de causas multifatoriais e caracterizada pela infiltração adiposa no parênquima hepático, excedendo 5-10% do seu peso. Apresenta forte relação com a síndrome metabólica – obesidade, resistência insulínica, diabetes mellitus II, dislipidemia. Objetivo: Esclarecer relação entre Doença Hepática Não Alcoólica e Obesidade. Metodologia: Revisão de literatura nas bases Scielo e PubMed, utilizando-se os termos fisiopatologia da doença hepática gordurosa não alcoólica e obesidade. Resultados e Discussão: A DHGNA é fator importante de morbimortalidade hepática, e o perigo dessa doença se dá pela evolução do infiltrado gorduroso, para inflamação (esteato-hepatite) e, posteriormente fibrose e carcinoma hepatocelular. Os hepatócitos são expostos a lipo/glicotoxicidade gerada pelos lipídios e, devido a isto, ocorre depleção hepática da lipogênese, inibição da lipólise periférica, aumento da resistência insulínica, produção e excreção excessiva de citocinas inflamatórias, gerando assim, o acúmulo de gordura, principalmente, na forma de triglicerídeos. A obesidade está associada a uma grande centralização de tecido adiposo e alterações metabólicas, logo, o IMC possui uma relação imperiosa com a DHGNA podendo ser um instrumento utilizado como rastreio de gravidade da esteatose hepática não alcoólica (DHGNA). É necessária a exclusão de outros fatores de risco que acrescentem pior prognóstico ao acompanhamento deste paciente como hepatites virais e etilismo. A realização de US, RNM e TC são exames que determinam o grau da esteatose. Conclusão: A DHGNA está fortemente relacionada à Síndrome metabólica, e à obesidade que é responsável pela centralização de tecido adiposo, um dos fatores de pior prognóstico. Sendo assim, a DMII e o grau do IMC do paciente são fatores resultantes que podem dispor todos os espectros da doença hepática. Portanto, é extremamente importante a adequação mudanças nos estilos de vida e tratamento farmacológico quando necessário.
Pancreatite Aguda: Uso da Colangiopancreatografia Endoscópica e Ultrassonografia no Diagnóstico e Tratamento
Authors: Da Silva Filho Daniel de Cristo , Macedo Gabriella Ferreira , De Andrade Gabriel de Sá Pitangui Antônio , Araújo Ana Roberta , Gama Pedro Figueiredo
Published: November 2022

Introdução: A pancreatite aguda (PA) é uma condição inflamatória do pâncreas; e confere como a patologia mais comum do trato gastrointestinal. Etiologicamente tem como causa a obstrução dos esfíncteres e ductos por cálculo, e o estilo de vida elitista. Dessa maneira,  a Colangiopancreatografia Retrógrada Endoscópica (CPRE) e a Ultrassonografia (USG) são as ferramentas utilizadas no diagnóstico e tratamento dessa patologia. E, quando bem indicados, auxiliam no prognóstico do paciente. Objetivo: O estudo tem como objetivo descrever a relevância da CPRE e USG no diagnóstico e tratamento da PA. Metodologia: Trata-se de uma pesquisa bibliográfica em que foram utilizadas as bases de dados online: Biblioteca Virtual em Saúde, SciELO e PubMed. Os descritores utilizados: “colangiopancreatografia endoscópica”, “pancreatite aguda” e “ultrassonografia”. Utilizou-se como critério de inclusão o tipo de artigo: estudo prospectivo, retrospectivo, randomizado e transversal, entre os anos “2018” a “2022”. Resultados e Discussão: O diagnóstico da PA inclui o exame imaginológico, sendo o mais utilizado, a USG transabdominal, visto que, possui boa sensibilidade para identificar litíase biliar, patologia que comumente desencadeia a PA. Além disso, possui facilidade de ser manuseada à beira leito, no caso dos pacientes críticos. Entretanto, apresenta limitações, principalmente no início da doença e devido a difícil visualização por ser um órgão retroperitoneal. A USG não possui especificidade para detecção de necrose, complicação frequente na PA. Já a CPRE, é um exame alternativo, capaz de detectar necrose no parênquima pancreático, ruptura do ducto pancreático e abcessos. Ademais, detecta complicações da PA e estima possíveis prognósticos. Assim, elucida a melhor intervenção e auxilia de forma clara no tratamento do paciente. Conclusão: Diante do exposto, fica evidente que o uso da CPRE para o  diagnóstico de pancreatite aguda é um método mais eficaz tanto no início quanto na fase necrótica da doença, enquanto a USG é inespecífica e limitada.
QSAR and Anticancer effect of Alkyl salicylate on Breast cancer T47D Cells Lines
Authors: Divina Elizabeth , Erlina Linda , Anbar Istiadi Khaerunissa , Yasa Putri Elfa Siska , Fadilah Fadilah
Published: November 2022

Cancer is a major health concern in both developed and developing countries, second leading cause of mortality worldwide. Among the different types of cancer, breast cancer is the most common cancer found in females worldwide. Studies have shown that salicylic acid decreases cell viability and potentially used in cancer therapy. This research aim is to analyze the cytotoxicity effect of alkylated salicylic acid towards breast cancer cells T47D. Samples used are methyl salicylate, ethyl salicylate, butyl salicylate, isoamyl salicylate, and octyl salicylate. Thin layer chromatography was done to samples and MTT test was done against T47D cancer cells to obtain cancer cell growth and IC50 value. QSAR analysis were carried out to predict the theoretical activity of the alkylated salicylates. Based on MTT result, there was shown an increase of cytotoxicity effect with higher concentration. IC50 value of alkylated salicylic acid showed more significant cytotoxicity effect (p<0,05) when compared to IC50 value of salicylic acid, except octyl salicylate. This shows that addition of alkyl group enhances cytotoxicity effect of salicylic acid due to increase of affinity. The IC50 value of alkylated salicylic acid showed lower results compared to salicylic acid. The QSAR equation is Log (1/IC50) = -1236.21871 - 236.42806 *logP(o/w) -1186.53810 * AM1_LUMO +251.55826* mr ((n = 7 r = 0,94 RMSE = 4,08). The QSAR showed the descriptors which has effect towards inhibition activity of breast cancer cell line are log P, mr, and AM_1LUMO.
A new stability indicating RP-UFLC method for the estimation of Tapentadol in tablet dosage forms
Authors: Kumar Kota Anil , Mathrusri Annapurna Mukthinuthalapati
Published: November 2022

Tapentadol is used for the treatment of hypertension and other cardiovascular failures. A new stability indicating RP-UFLC method has been proposed for the estimation of Tapentadol in tablet dosage forms. A mixture of 10 mM ammonium acetate: acetonitrile (48:52) was chosen as mobile phase (Isocratic mode) with flow rate 0.8 mL/min (Detection wavelength 273 nm). Shimadzu Model UFLC system with PDA detector and X Bridge C18 Column was used for the study. Tapentadol obeys Beer-Lambert’s law over the concentration range 0.5-200 µg/mL with linear regression equation y = 11991x + 4407 (R² = 0.9999). The LOQ and LOD were found to be 0.4871 µg/mL and 0.1593 µg/mL. Stress degradation studies were performed such as acid hydrolysis, alkaline hydrolysis, thermal treatment and oxidation according to the ICH guidelines. The proposed UFLC method has validated and found to be simple, precise, accurate, robust and is very much useful for the analysis of Tapentadol tablets.
Toxic effects of Cyclophosphamide on Hepatic and Kidney tissues in Albino Mice Model
Authors: Zuhair Alsaidi Zahraa , H. Humaish Haider , Alasadi Amer
Published: November 2022

cyclophosphamide (CPA) is anti-tumor drug and is used for chemotherapy. CPA is a poisonous medication that hits both tumor and healthy cells in the body. The active ingredient is inactive in vitro and is replaced by metabolites, the most important of which is phosphoramide mustard. The goal of this study was to see how cyclophosphamide affects the histology of the liver and kidney tissues in mice animal model, as well as how it affects their biochemical functions. Twenty adult male Albino mice were randomly assigned to control and CPA treated group. CPA was given to the mice at dose of 200mg per kg body weight. After (25) days of treatment, mice were sacrificed. Hematoxylin and Eosin stains (H and E) were used to test the toxic effects of CPA on the liver and kidney histology. Our data showed the harmful effects of CPA drugs in the liver and kidney tissues, pathological changes were ranging from slight infiltration to sever necrosis and finally cytolysis also was observed. CPA-treated mice showed a significant (P<0.01) increased in serum creatinine, urea, and urea nitrogen levels. CPA-treated mice showed a tubular necrosis and inflammatory cell infiltration, as well as nephrotic changes when compared to control. CPA treatment demonstrated a significant (P<0.01) increased in Alanine Amino-Transferase (ALT), Aspartate Amino-Transferase (AST), Albumin and Bilirubin levels. Furthermore, livers of CPA-treated mice exhibited hepatocyte necrosis around central veins. Our data revealed the damaging and toxic effects of CPA against liver, kidney tissues and their biochemical functions.
Molecular typing of MDR-K. pneumoniae using ERIC-PCR Technique
Authors: Shahadha Abed Nihad , Kariptaş Ergin , Abed Lateef Safaa
Published: November 2022

Klebsiella pneumoniae is a Gram-negative bacterium that exists naturally in the human body's gastrointestinal tract as part of the natural microflora. It has long been recognized as one of the most frequent nosocomial diseases and a multidrug resistant pathogen. The purpose of the current work was to determine the antimicrobial susceptibility and genetic relatedness of K. pneumoniae strains obtained from Ramadi hospitals, western Iraq, using the ERIC–PCR approach. In the period between June and September 2021, 51 K. pneumonia isolates were obtained from Anbar hospitals. After normal laboratory procedures and differential assays identified K. pneumoniae isolates, disk diffusion susceptibility testing was performed. Also, ERIC-PCR was used to determine genetic relatedness of 15 MDR K. pneumoniae isolates. Kirby –bauer disk diffusion test showed that among K. pneumonia isolates, the highest antibiotic resistance was to Augmentin (96%), cefotaxime (92%), ceftriaxone =Ceftazidime (88%), Amikacin (48%), Levofloxaccin (42%), and imipenem (26%). More than 66.66% of the isolates revealed multi-drug resistant phenotypes. ERIC-PCR results and data analysis indicate that there are 23 distinct ERIC types. The findings of this study show an increase in the prevalence of multiresistant K. pneumoniae in the hospitals studied. The ERIC PCR results revealed a high level of genetic diversity across K. pneumoniae strains, showing that K. pneumoniae isolates are polyclonal in Anbar hospitals.
The effect of vitamin D and Physical exercise on glycaemic control in patients with Type 2 Diabetes Mellitus(DM)
Authors: Majeed Mehwish , Rasool Shaheena , Nazir Tauseef , Mohd. Adil
Published: November 2022

Background: The purpose of this study was to find correlation between vitamin D, Physical exercise on glycaemic control in patients of type2DM. Methods: The study was conducted from November 2019 to December 2020 among subjects above 40 years of age at sub-district hospital Sopore, North Kashmir. Total 400 patients diagnosed with diabetes were registered for the study. Questionnaire containing relevant patient information was collected at regular intervals. Statistical analysis were performed. Results: Biochemistry values in the studied subjects with Type2DM compared to healthy controls in the study revealed that fasting glucose level,HbA1c,LDL,triglycerides,uric acid were higher inT2DM group compared to the control group. The results of our study showed that Vitamin D deficiency, lack of physical exercise, family history of T2DM, hypertension and smoking were significant predictors of diabetes. In Type2DM patients, mean vitamin D value was 21.45ng/ml opposed to 40ng/ml in the control group. Also physical activity was found to be higher in control group when compared to cases with p -value less than 0.00001. Also family history of DM was significantly higher in cases when compared to control group with p-value of 0.044.There was also statistically significant difference when parameters like HTN and smoking were compared (both higher in cases as against the control group) between two groups with p value 0.044 and 0.029 respectively. Conclusion: Vit D, physical exercise,family history of diabetes may be contributing factors for the rising burden of diabetes globally and in India.We need to take cognisance of the factors leading to the rising global burden of DM and take appropriate and necessary measures to stop this growing menace.
Cone-beam Computed Tomography Evaluation of Non-surgical management of a Large Periapical Lesion using Calcium hydroxide intracanal medicament: A 1-year follow-up case report
Authors: N J Nagaraj. , Nesamani Ravikumar , Sekar Mahalaxmi , S Pallavi.
Published: November 2022

This case report aims to assess the healing of a large periapical lesion non-surgically using Calcium hydroxide (CH) with the aid of Cone Beam Computed Tomography (CBCT). A 28-year-old female patient presented with pain and swelling in the lower anterior teeth (31, 32, 41, 42) (Federation Dentaire Internationale (FDI) tooth notation system). Patient history and pre-operative radiographic examination revealed incomplete root canal treatment in relation to 31, 32, 41, 42 with periapical abscess. During the first visit, the access cavity was modified, followed by determination of the working length and biomechanical preparation. In the present case report, (CH) intracanal medicament(ICM) was placed in the canals for 2 weeks, and the process was repeated until the canals were dry. Once the canals were dry and the teeth became asymptomatic, obturation was performed. Permanent coronal seal was provided using composite restorative material. One year periodic follow-up was carried out to assess the healing of the periapical lesion, following which, post-operative healing was assessed with the help of CBCT- Periapical Index (CBCT-PAI) and was compared with the pre-operative CBCT-PAI. Regression of the lesion and formation of the trabecular pattern of the bone were noted. Intracanal medication with calcium hydroxide complemented the instrumentation with irrigation and optimal disinfection of the root canal system. In this case report, the use of CBCT as a diagnostic tool helped in the accurate measurement of periapical lesion size.
Brucellar Spondylitis causes Alteration in Serum protein and Electrophoretic pattern
Authors: M. Taha Ekhlass , Mohialdeen Taha Muzahem , Abu-Shana Jinan Hameed , Rahim Saleh M. , Mohammed Abdullah Mays
Published: November 2022

Background and Objectives: The frequency of Brucellosis is expanding in the Middle East particularly in Iraq. Spondylitis is the most incessant difficulty, yet it is hard to analyze in light of the fact that its clinical side effects are vague. The cross-sectional study was conducted to evaluate abnormal serum protein electrophoresis patience living with brucellar spondylitis and it is related to the disease. This study shares out the distribution of protein pattern in Brucellar spondylitis patients. Methods: The current study included a total number of 40 voluntary subjects covers of 25 cases and 15 controls. Total serum protein was determined using the biuret method, serum albumin was determined using bromocresol green method, Serum protein electrophoresis was determined using SAS-MX serum protein gel. Results: Total proteins, Alpha 1 Globulin, and Gamma Globulin were significantly increased in Brucellar spondylitis when compared to controls. Ratio Albumin/Gamma was significantly decreased in Brucellar spondylitis compared to control. Albumin, Alpha 2 Globulin, and Beta Globulin did not appear significant difference. According to the multivariable regression analysis the level of Alpha 1 Globulin was highly related to total protein in Brucellar spondylitis. The cluster analysis showed that the investigated parameters organized into four clusters in the serum of patients with Brucellar spondylitis. Conclusion: we conclude that Total proteins, Alpha 1 Globulin, and Gamma Globulin have altered in patients Brucellar spondylitis when compared to control, Also Alpha 1 Globulin was associated with total protein in the studied cases.
Design and Evaluation of Pulsincap System Containing Nanosuspension of Montelukast Sodium for Chronotherapy in Asthma
Authors: Cherukuri Sowmya , Vuppalapati Lavakumar , Narayanan Venkateshan
Published: November 2022

In the present study, an attempt was made to prepare a pulsincap chronomodulated drug delivery system for the treatment of asthma and associated early morning allergy. Pulsincap capsule was prepared by sealing the drug nanosuspension inside the formaldehyde treated insoluble capsule bodies with a swellable and erodible guar gum plug. The drug, Montelukast sodium (MLS) nanosuspension was prepared by emulsion-solvent evaporation method using HPMC E15 and sodium lauryl sulphate (SLS). Nanosuspension formulations were optimized by using statistical Central composite design (CCD) for the required size and stability. The entire capsules were enteric coated using Cellulose acetate phthalate (CAP). This enteric coat prevents the drug release in the stomach, further the swellable hydrogel plug protect the nanosuspension to maintain the lag phase (5h) and facilitate its burst release in the colon. The length of this lag phase depends upon the concentration and quantity of the hydro gel plug. In order to simulate the GIT environment, the dissolution studies were performed using a sequential pH change method. DSC studies confirmed the absence of drug-excipient interactions. From the design space provided by the CCD, F14 and F15 formulations were considered as optimized. SEM studies were conducted for F14 formulation and this was filled in the Chronomodulated pulsincap systems (CMPs). These CMPs showed the drug release after 5h lag phase. Hence, when CMPs containing MLS nanosuspension is administered during bed time, it starts releasing the drug at the early morning hours to reduce asthma and associated early morning allergies like rhinitis and sneezing. Further, extensive in vivo studies are needed to be conducted to confirm the efficiency of these CMPs.
Determination of Saturated Ketoconazole Solubility Using Spectrophotometry Uv-Vis Method
Authors: Annisa Viviane , Saifullah Sulaiman Teuku Nanda , Kharis Nugroho Akhmad , Endro Nugroho Agung
Published: November 2022

Ketoconazole is a weakly basic drug that has lower solubility at higher pH. Determination of solubility of ketoconazole in the base solution is not easy due to the poor solubility. The simple, low cost, efficient, accurate spectrophotometry methods in UV/VIS region have been developed for the determination of ketoconazole. The wavelengths were selected at 230 nm using solvent buffer phosphate pH 6.8. The Beers’ law was obeyed in the concentration range 5-50 ppm. According to ICH guidelines the parameters such as linearity, accuracy, precision, the limit of detection, and the limit of quantification were studied. The regression equation of calibration curve was found to be y=0.0448x-0.13. All concentrations were linear, with the absorbance having a correlation coefficient 0.9994. The accuracy was found between 93.84-95.95%. The % Relative Standard Deviation (RSD) of Ketoconazole was found to be 0.112-1.237 for intraday and 0.008-0.792 for interday precision. The result of the limit of detection (LOD) for ketoconazole was 0.988 that could be reliably detected and the limit of quantification (LoQ) for ketoconazole was 3.294 ppm. The result of ketoconazole solubility was 21.044±0.759 ppm that indicating ketoconazole was a poorly soluble drug in the intestine. The proposed methods could be applied to the determination solublity ketoconazole in buffer phosphate pH 6.8 with good accuracy, good precise, and simple.
Extract of Gigartina sp for Antibacterial Activities on Escherichia coli and Staphylococcus sp.
Authors: Shinta Maharini Fransisca , Nambiar Nisha , Poddar Sandeep
Published: November 2022

Gigartina sp. was one of the red algae used as natural drugs due to its bioactive compounds i.e. acrylic acid, alkaloid compound, and phenol acting as antimicrobials. One of the methods to conduct antimicrobial isolation was extraction by maceration using solvent. Antimicrobial compound could provide various effects i.e. bacteriostatic, bacteriolytic, and bactericidal. Antimicrobial activities were measured by applying Minimum Barrier Concentration method. The research aimed to investigate antibacterial activities of Gigartina sp. algae extract, to find the optimum Gigartina sp. algae extracts to impede the growth of the tested microbes, to make a comparison between the antibacterial activities of Gigartina sp. algae extracts and that of antibiotic types, and to investigate the effects of the antibacterial characteristics of Gigartina sp on the growth of the tested microbes. Antibacterial activities were tested using agar dilution and liquid dilution with 0, 10, 15, 20, and 25mg/ml content. Antibacterial characteristics were found by measuring the total number of cells and the number of living cells in Gigartina sp. extract culture. Gigartina sp. algae extract with ethanol extracts gave a stronger effect to antimicrobial activities of S. aureus and E. coli than that with hexane and aqueous extracts. Areas of barrier zone on E. coli and S. aureus were 0.194cm2 and 0.378cm2 respectively. Gigartina sp. algae extract with ethanol extract on E. coli indicated activities similar to that of streptomycin and showed a significantly similar result between penicillin and streptomycin, so did Gigartina sp. alage extract on S. Aureus. The type of antimicrobial compound restriction of Gigartina sp. algae was bacteriolytic.
Ensuring safety of Novel Oral Anticoagulants Predictable Dose Response Relationship
Authors: Yerrakula Goutham , Gideon George Samuel , Vijaya Kumar PR Anand , Kumar D Krishna , Venkatachalam Senthil
Published: November 2022

Atrial fibrillation (AF) is also the most common cause of cerebrovascular morbidity and mortality in cardioembolic stroke patients. In patients with AF, oral anticoagulation treatment has shown to minimise the risk of cardioembolic stroke by more than half. Anticoagulation with vitamin K antagonists is best used with strict adherence and monitoring. Patient dissatisfaction can be caused by a number of causes, all of which lower the patient's excellence of life. New immediate oral anticoagulants, for example, the immediate factor Xa inhibitors apixaban, edoxaban, and rivaroxaban, and the dabigatran thrombin inhibitor, were intended to defeat the shortcomings of conventional anticoagulant drugs. However, models to boost the estimation of treatment and guarantee that treatment can be securely proceeded are missing for existing oral anticoagulants. This survey will briefly examine the new oral anticoagulants dabigatran, apixaban, edoxaban, and rivaroxaban, with an attention on their utilization in the anticipation of embolic events in AF. It will look at the benefits for patients of life, just as the protection and adequacy of the treatment.
Influence of Vitamin K intake on INR and Anticoagulation in outpatients taking Warfarin
Authors: Aliza Putriana Norisca , Rusdiana Taofik , Rostinawati Tina , Rizki Akbar Mohammad
Published: November 2022

Warfarin is a type of vitamin K antagonist anticoagulant used to thromboembolic prevention and its maintenance dose differs significantly among patients. Moreover, the factor influencing the dose calculation is known as genetic polymorphism, while the influence of vitamin K intake while the effect of vitamin K intake is still a matter of debate. This study aims to provide an overview of several studies on the effect of vitamin K intake on the stability of the PT-INR value and anticoagulation in warfarin therapy patients. A study was conducted on the effect of vitamin K intake on the PT-INR value stability and anticoagulation in warfarin therapy patients. One study showed that there was no significant correlation between vitamin K usual intake and the anticoagulant effect, while in another, it was found that the stability of this effect is achievable with adequate amounts of the vitamin intake. Furthermore, another study showed that the anticoagulant effect is more stable in patients with excessive vitamin K intake on long-term warfarin use. However, other study showed that INR values will stabilize if vitamin K intake is relatively low. The results from various studies were different, therefore, there is a debate regarding the influence of vitamin K intake on the PT-INR value and anticoagulation.
USER ACTIVITY MODELING BASED ON MARKOV CHAIN
FOR RADIO ENVIRONMENT MAP IN COGNITIVE RADIO NETWORKS
Authors: ADAMOVSKIY Y. , BOHUSH R. , CHERTKOV V. , NAUMOVICH N. , STEGKO I.
Published: November 2022

A technique for generating schedules of movement and data transmission sessions for subscriber devices
of a simulation model for constructing a radio environment map for a cognitive cellular communication system is presented.
The technique defines the subscriber’s behaviour as pseudo-random on small time scales, but periodically
repeating over large intervals. The impact on the behaviour of several time parameters is taken into account: day types,
such as working, weekend, holiday; weekday number; the week number of the month. Scenarios are generated using
binary sequences obtained using a Markov chain and an impulse noise generator to change the subscribers state.
The software model implementation is made in MatLab package, the results of studies are presented that confirm
the correctness of the model and the possibility of using the proposed approach to form a radio environment map.
Egészség- és rizikómagatartások összefüggései biológiai szintű termékenységi mutatókkal, férfiak körében
Authors: Smohai Máté , Osváth Péter , Mészáros Veronika , Kovács Dóra , Tanyi Zsuzsanna , Jakubovits Edit , Péczka Anita , Kövi Zsuzsanna
Published: November 2022

Bevezetés: A kutatások azt mutatják, hogy míg nőknél elsősorban egészségügyi problémák a meddőség fő kiváltói, addig a férfiaknál az elsődleges kockázati tényező az életmód (KSH, 2015). Jelen tanulmány célja feltárni bizonyos egészség- és rizikómagatartások összefüggéseit biológiai szintű termékenységmutatókkal, férfiak körében. Hipotéziseink szerint a sporttevékenység pozitív irányban, az alkohol- és dohányfogyasztás, valamint a BMIindex negatív irányban kapcsolódik a biológiai szintű termékenységi mutatókhoz. Módszertan: A vizsgálatban 129 felnőtt férfi vett részt, hozzáférés alapú mintavétellel. Keresztmetszeti módon kerültek felvételre az egészség- és rizikómagatartások tényezői (orvosi anamnézisben és szociodemográfiai kérdőívben), valamint maga az andrológiai vizsgálaton belüli férfi termékenységmutatók: spermiumkoncentráció, spermiumszám, progresszív motilitás, nem progresszív motilitás, motilitás, normál morfológia és vitalitás. Az adatok elemzése korrelációs és független mintás egyszempontos varianciaanalízis elemzésekkel történt. Eredmények: A végrehajtott korrelációelemzések a hipotéziseinknek megfelelő irányú korrelációkat eredményeztek, azonban ezek közül mindössze a BMI index és a sportolással töltött napok száma áll szignifikáns kapcsolatban bizonyos termékenységi mutatókkal. A varianciaanalízisek alapján ugyanez mondható el azzal a kiegészítéssel, hogy a nem sportolók szignifikánsan alul maradtak a legalább minimális mennyiségben sportolókhoz képest spermiumszámot illetően. A sportolók csoportján belül viszont a hetente 2-5 órát sportolók spermium motilitása volt szignifikánsan magasabb a keveset (heti 0-2 órát) sportolókénál. Következtetések: A meglepően kevés mennyiségű szignifikáns eredmény arra utal, hogy önmagában az egészséges életmód a termékenységi mutatók varianciájának igen kis százalékát magyarázza.
A kötődési minták, a szülői bánásmód és a halogatás összefüggése
Authors: Jakubovits Edit , Mészáros Veronika , Pásztor Klaudia , Tanyi Zsuzsanna , Kovács Dóra , Smohai Máté , Szili Ilona , Kövi Zsuzsanna
Published: November 2022

Célkitűzés: Az elmúlt években egyre több kutatás keresi arra a választ, hogy melyek azok a tényezők, amelyek befolyásolhatják a felsőoktatásban résztvevők körében nagy százalékban előforduló halogatást, ami a tanulmányok befejezését is hátráltatja, és kedvezőtlen egészségi hatásai is lehetnek. A legtöbb eddigi tanulmány elsősorban intraperszonális tényezőkre fókuszált, mint az önértékelés, önszabályozó képesség, időbeli perspektíva, teljesítménymotiváció. Ezek alapján elkülöníthető a halogatás két típusa a nagyobb önértékeléssel és önbizalommal jellemezhető „aktív” és a hagyományos értelemben vett „passzív” halogatás. Ezzel szemben viszonylag keveset tudunk a halogatás interperszonális tényezőiről. Ebben a tanulmányban arra kerestük a választ, hogy a halogatásra jellemző személyiségjegyek kialakulásának szempontjából fontos korai szülő-gyermek kapcsolatok felnőttkori reprezentációi és a kialakult kötődési minták típusai milyen módon határozzák meg a halogatás jellegét. Módszer: Vizsgálatunkban felnőtt magyar vizsgálati mintán (N=400) vetettük össze az aktív-passzív halogatás mértékét a felnőtt kötődési stílus típusaival és a szülői bánásmód felnőttkori reprezentációjával. Eredmény: Összefüggést találtunk a biztonságos és bizonytalan kötődési stílusok és az aktív és passzív halogatás között. A bizonytalanul kötődőkre inkább a passzív halogatás jellemző, a biztonságosakra pedig az aktív. Ezen belül a tudatos döntés a halogatásról, ami az aktív halogatás egyik faktora, inkább a bizonytalan kötődéssel mutatott pozitív összefüggést. Igazoltuk, hogy a szülői elutasító bánásmód emlékei együttjárást mutatnak az ambivalens-félelemteli kötődési stílussal, ami esetében a passzív halogatás nagyobb mértékben fordul elő.
Sars-cov-2 infection and vaccination in children and adolescents, and rule of cloud computing in healthcare system
Authors: Maziar farhadi  , Nahid Masoodpoor  , Pouria Rahnama
Published: November 2022

The beginning of the COVID-19 pandemic in the world has brought many problems to the world. It is a respiratory disease. Dry cough and fever are known as their most common symptoms. When a sick person sneezes or coughs, the virus can be transmitted from one person to another through small droplets. Although this disease is generally milder in children than adults, severe cases and even death have been reported among children and adolescents. The aim of this study is to provide a review of the information that has been published so far about this disease in children and adolescents.
Communication and building social capital in community supported agriculture
Authors: Furness Ella , Sanderson Bellamy Angelina , Clear Adrian , Mitchell Finnigan Samantha , Meador J. , Mills Susanna , Milne Alice , Sharp Ryan
Published: November 2022

Community supported agriculture (CSA) schemes (programs) provide an alternative means for ob­taining produce, through direct purchase from farms. They are also often driven by a vision of transforming the current mainstream food system and seek to build a community of people who sup­port this vision. Social capital refers to the net­works and ties between people and groups and the impact of these ties on access to influence, infor­mation, opportunity, and ability to organize. Social capital is built by CSAs and helps foster and stabi­lize the grassroots agricultural innovations that are needed for the development of sustainable food systems. Using the concept of social capital, we studied communication methods of four CSAs in the UK, examining the interactions between CSAs and their members and within each of their mem­bership groups. We carried out in-depth interviews with 49 CSA members to establish what interac­tions they had with their CSA and with other mem­bers, and analyzed our data thematically to identify the characteristics of interactions that were impor­tant to participants. We consider how our research may benefit CSA organizations by enabling them to learn what their members want and to learn about the varied ways in which members conceptu­alize their experiences of community derived from their membership. We found that the various CSA communication strate­gies, which consist of fre­quent and varying virtual and face-to-face interac­tions, are able to promote development of both bridging and bonding social capital. Over­all, there is a desire for social connec­tion in CSA member­ships. Furthermore, in CSAs where mem­bers can interact easily, there is potential for CSA member­ship to provide mem­bers with communi­cation that is important as a source of both knowl­edge and social connection. CSAs can maximize both social capital and mem­ber satisfaction by using a range of communication media and methods to meet their members’ circumstances and preferences.
Honestas and the Angevin Queen: Eleanor of Aquitaine’s Letters and Their Classical Rhetorical Antecedents
Authors: Ramsey Shawn
Published: November 2022

In 1193, King Richard I of England was taken captive by the Holy Roman emperor Henry VI. In several letters, the captive Richard’s mother, Eleanor of Aquitaine, exhorted Pope Celestine III to intercede on her son’s behalf. The specific topics on which she drew were ancient concepts within the topic of honestas, or virtue, and, more specifically, justice as one of the virtues. Justice occupied a preeminent place among the other virtues in medieval thought, and topics related to justice, as a species of honestas, were traditionally regarded as proper for deliberative argumentation. Eleanor’s letters set forth an argumentative schema regarding the nature of justice, asserting that it possesses an anatomy of subordinate parts that include friendship, pity, and the body politic of the kingdom. Her appeals illustrate the significance of ancient virtue theory in medieval political persuasion as an inheritance of Ciceronian thought, the place of virtue in geopolitical civic persuasion in her day, and how women implemented and conceived of social justice from classical rhetorical sources and employed them for civic ends.
William Molyneux’s Problem and Nathaniel Hawthorne’s “My Kinsman, Major Molineux”
Authors: Dawson Jon
Published: November 2022

This essay analyzes Nathaniel Hawthorne’s “My Kinsman, Major Molineux” in relation to a thought experiment proposed by William Molyneux, who questioned whether a blind man, if given the ability to see, could identify an object by sight that he had known by touch. Molyneux asserted that the man would not recognize the item because nothing in his past had equipped him for the task, and this position reflects the contours of Hawthorne’s narrative. The protagonist, Robin, cannot accurately process events due to the fact that the knowledge gleaned from earlier experiences does not correlate to his present circumstances. This article connects the limitations of Robin’s perceptions to political tensions as his worldview centers on the prominence of Major Molineux, a colonial administrator, and the youth cannot grasp the implications of sensory evidence that does not conform to these suppositions. Through his experiences in his new environment, however, Robin develops the empirical foundation necessary to progress from merely perceiving phenomenon to understanding their broader implications. This development highlights the need to transcend prescriptive categories of thought to gain a clearer conception of reality.
Through Another Looking Glass: The Complex Satires of Twain’s “A Fable”
Authors: Brenner Gerry
Published: November 2022

Unlike much of Twain’s short fiction, the satiric targets of “A Fable” are numerous, not singular; its tendentious moral invites dialogical interpretations of how “the mirror of one’s imagination” enriches, not impoverishes, an engagement with a text.
The Power of Girls and Women in Flannery O’Connor’s Fiction
Authors: Fowler Doreen
Published: November 2022

Claire Katz states that Flannery O’Connor’s portrayal of women and girls is “dominated by a need to expose their weakness.” This essay demonstrates that her view of male and female power evolved throughout her career. In her early fiction, she represents women as weak and boys as powerful. In “A Circle in the Fire,” three young boys dominate a mother and a young girl. In her later fiction, she shows that male power is a mere illusion and that girls and women are more powerful than male figures. This essay provides instances of female power in three of her later works, “The Comforts of Home,” “A View of the Woods,” and “Revelation.”
Suplementação luminosa aplicada ao cultivo de hortaliças
Authors: Teixeira Messias de Lara , Machado Luis Eduardo da Rosa , Feil Dion Lenon Prediger , Luz Paulo César Vargas
Published: November 2022

A iluminação artificial aplicada na agricultura é uma tecnologia que já vem sendo utilizada no cultivo de plantas, podendo ser utilizadas de maneiras diferentes, tais como o cultivo indoor e a suplementação luminosa, que incrementa as horas de luz que determinada planta recebe diariamente. Devido à importância que este tema aborda, e com a carência de estudos que demonstrem a viabilidade da utilização da iluminação artificial na agricultura, o presente trabalho apresenta um estudo de forma prática no âmbito da suplementação luminosa, verificando o impacto e a viabilidade econômica da aplicação de um sistema no cultivo de alface (Lactuca sativa). Para aplicar este estudo, foram implementados 10 canteiros para cultivo de alface, contendo iluminação artificial com lâmpadas LED. Os resultados de um ciclo de cultivo e colheita indicam o tempo ótimo de suplementação luminosa em 6 horas diárias, impactando em crescimento de aproximadamente 47% maior nas hortaliças com suplementação, em comparação aos pés sem a técnica.
Is there a need for an e-module focused on contextual teaching and learning to improve student critical thinking? A preliminary examination into needs assessment
Authors: Pratama Siska , Haenilah Een Yayah , Adha Muhammad Mona
Published: November 2022

The aim of this study was to analyze electronic modules in improving 21st century skills on the background of problems that exist at SDN 03 Negeri Batin in class III, namely the lack of use of teaching materials in the learning process which associated with daily life as learning resources, teachers merely used learning textbooks as the only learning resource. This study used descriptive qualitative research. Questionnaire data collection obtained through questionnaire and documentation. The data analysis method used was data reduction, data presentation and conclusion. Questionnaires were given to 13 teachers and calculated using the Likert scale formula. The results of the study indicated that creativity and innovation of 82.82% and it was considered as feasible, critical thinking and problem solving consisted of 81.41% which showed feasible, communication and collaboration consisted of 87.82% which considered as feasible.
An analysis of digital teaching material in increasing the critical thinking skill of elementary school students
Authors: Purbawati Anita , Haenilah Een Yayah , Samhati Siti
Published: November 2022

The low critical thinking of students at MI Muhammadiyah Banjarsari Metro in 2013 Curriculum learning creates teaching materials to be very important for learning activities in the classroom, from developing teaching materials can make it easier for students in understanding the material and more active to know more about the material being taught. The aim of this study was to find out the analysis of digital teaching materials on the critical thinking skills of elementary school students. This study was a qualitative descriptive with data collection using observation and interview techniques to 5 teachers and 46 students. This data analysis was data reduction, data presentation, and verification. The results of this study indicated students of MI Muhammadiyah Banjarsari Metro Class III still used student books or teacher books, then the teaching materials developed have not shown elements of critical thinking skills, and were not digital-based in the learning process, thus, the alternative solution requires digital teaching materials to improve skills. Students’ critical thinking in elementary school thematic learning.
Pirls-based cognitive assessment instrument: How effective is it for measuring Indonesian language reading literacy in fifth grade?
Authors: Pratiwi Yuli Putri , Rusminto Nurlaksana Eko , Perdana Ryzal
Published: November 2022

The Indonesian reading literacy test is a technique for evaluating students’ cognitive reading abilities. However, as of yet, the test questions administered to students are inadequate to assess certain parts of their Indonesian reading literacy. Therefore, the purpose of this study was to develop an adequate and standardized cognitive assessment instrument based on the PIRLS model to measure students' Indonesian reading literacy. The participants in the study were fifth graders from an elementary school, SD Negeri 11, located in Metro City, Lampung Province, Indonesia, with a total of 293 students. This study adopted a research and development design. The results indicated that the cognitive assessment instrument based on the PIRLS paradigm that was developed to measure Indonesian reading literacy in fifth graders delivered adequate and standardized items
Koronavirüs Korkusu, Hastalıktan Korunma ve Tedavisinde Bütünsel Tamamlayıcı ve Alternatif Tıp Kullanımına İlişkin Tutumu Etkiler mi?
Authors: KARACAN Emine , SAPÇI Esin , GÜNGÖRMÜŞ Zeynep
Published: November 2022

Bu çalışma, koronadan korunmak için kullanılan alternatif yöntemleri belirlemek, korona ile alternatif yöntem kullanımı arasındaki ilişkiyi göstermek amacıyla yapılmıştır. Tanımlayıcı ve ilişki arayıcı tasarımla yapılan araştırma, Gaziantep ilinde yaşayan ve çalışmaya dahil edilme kriterlerini taşıyan 455 bireyin katılımıyla Mart-Mayıs 2021 tarihlerinde gerçekleştirilmiştir. Araştırmanın verileri, Koronavirüs (Covid 19) Korkusu Ölçeği (FCV-19S), Bütünsel Tamamlayıcı ve Alternatif Tıp Ölçeği (HCAMQ) ve araştırmacılar tarafından hazırlanan Tanıtıcı Özellikler Formu kullanılarak toplanmıştır. Veriler SPSS 23.0 paket programıyla değerlendirilmiştir. Katılımcıların orta düzeyde koronavirüs korkusu yaşadıkları ve koronavirüs korku ölçeği ile bütüncül tamamlayıcı ve alternatif tıbba karşı tutum ölçeği toplam puanları (r=0.145) arasında pozitif yönde anlamlı derecede bir ilişki tespit edilmiştir (p<0,05). Ayrıca katılımcıların bitki çayları, soğan/sarımsak, D, C vitaminleri ve multivitamin tüketimine ağırlık verdikleri belirlenmiştir. Koronavirüs korkusunun, insanların alternatif yöntem kullanımını etkilediği görülmüştür.
Toplumun Akılcı İlaç Kullanımına İlişkin Bilgi ve Uygulamalarının Belirlenmesi: Çankırı İli Örneği
Authors: ŞAHİN Nilay , SUCU ÇAKMAK Nefise Cevriye , SÖNMEZ Deniz Zeynep
Published: November 2022

Amaç: Bu çalışma, Çankırı İli’nde yaşayan bireylerin akılcı ilaç kullanımına ilişkin bilgi ve uygulamalarının belirlenmesi amacıyla yapılmıştır.
Gereç ve Yöntem: Çalışma, tanımlayıcı özellikte olup, evrenini Çankırı İli’nde yaşayan bireyler oluşturmaktadır. Araştırmaya 18 yaş ve üzerindeki, bilişsel, duyuşsal ve iletişim problemi olmayan bireyler dahil edilmiştir. Araştırma 437 katılımcı ile tamamlanmıştır. Araştırma örneklemi tesadüfi olmayan örnekleme türlerinden olan kolayda örneklem metodu ile belirlenmiştir. Veriler, veri toplama formu ile Haziran- Ağustos 2021 tarihleri arasında, yüz yüze görüşme tekniği kullanılarak toplanmıştır.
Bulgular: Katılımcıların akılcı ilaç kullanımına yönelik bilgi ve uygulamalarının dağılımı incelendiğinde, %29,7 ‘sinin gereksiz yere ilaç yazdırma eğiliminde olduğu, %27,4’ünün kendi kendine antibiyotik kullandığı, %40,5’inin ilacın kullanma talimatını okumadığı belirlenmiştir. Katılımcıların akılcı ilaç bilgi ve uygulamaları sosyodemgrafik özelliklerle karşılaştırıldığında; kendi kendine antibiyotik kullanmanın yaş, cinsiyet, medeni durum, eğitim düzeyi ve kronik hastalık varlığı ile ilişkili olduğu bulunmuştur (p<0,05).

Sonuç: Çalışmamızda toplumun akılcı ilaç kullanımına yönelik bilgi ve uygulamalarının yetersiz olduğu, özellikle eğitim seviyesinin azalmasıyla birlikte akılcı ilaç kullanımının da azaldığı görülmüştür. Çalışmamızdan çıkan sonuçlara göre Çankırı İli’nde yaşayan bireylere, akılcı ilaç kullanımına ilişkin farkındalık eğitimlerinin düzenlenmesi önerilmektedir.
Effectiveness of insertion care bundle to prevent Central-line-associated bloodstream infections at Pediatric ICU
Authors: Charalampia Nteli  , Pantelis Perdikaris  , Barbara Boutopoulou  , Efrosini Vlachioti  , Ioannis Kasimis  , Despoina Koumpagioti  , Vasiliki Matziou
Published: November 2022

Purpose: Central-line-associated bloodstream infections are the most common healthcare- associated- associated infections in Pediatric intensive care units worldwide. The aim of this survey was to quantify the impact of central-line care bundle insertion to the prevention Central-line-associated bloodstream infections in a Greek Pediatric Intensive Care Unit. Methods: All patients with non- tunneled central venous catheter admitted to the unit between October 2012 and October 2015 were included in the cohort study. After twenty-six months of surveillance, a Central-line-associated bloodstream infections prevention insertion bundle was introduced. The insertion bundle derived from the Centers for Disease Control and Prevention recommendations. Results: One hundred fifty one patients were enrolled in the present study. The incidence rates of CLABSIs decreased from 14.0 (pre-intervention period) to 4.8 (post-intervention period) per 1000 central venous catheter-days (p = 0.041, 95% Confidence Interval: 0.7023- 17.7), whilst the central-line utilization ratio was increased from 0.51 to 0.59 (p=<0.002, 95% Confidence Interval: 0.039-0.1258). The insertion-bundle compliance was 95.3% in the post- intervention period. Conclusions: According to the results the implementation of insertion bundle has the potential to reduce the incidence of Central-line-associated bloodstream infections. A prevention strategy targeted on the insertion of vascular access can decrease the incidence rates of Central-line-associated bloodstream in pediatric intensive care units.
Extent of use of QT interval prolonging drugs in psychiatry: A pilot study
Authors: Chayna Sarkar  , Arvind Nongpiur  , Arky Jane Langstieh  , Julie Birdie Wahlang  , Biswadeep Das  , Melambha Surong
Published: November 2022

A number of drugs are capable of prolonging the QT interval either alone or in combination. Excessive prolonging of QT interval could lead to a potential life threatening fatal abnormal rhytm called Torsades de Pointes. Many antipsychotics drugs were found to have a detrimental effect on the QT interval. The increase in the incidence of sudden cardiac death has been found to be related to the antipsychotic treatment. Many patients taking these drugs mostly psychiatric patients posed to be at a greater risk of developing sudden cardiac death or TdP. Hence, clinicians prescribing these drugs to patients must be alert and aware of the dangerous effect these drugs have on the patients and if possible, to avoid prescribing drugs having with risk of developing QT interval prolonging effect as far as possible.