bluuebunny/crossref_metadata_2025 huggingface dataset:
Acción e institución en el pensamiento político de Hannah Arendt: lecturas de Sobre la Revolución
Authors: Smola Julia Gabriela
Published: December 2017

***Ação e instituição no pensamento político de Hannah Arendt: leituras de Sobre a Revolução***Como diz Margaret Canovan, On Revolution é um dos livros menos estudados y menos compreendidos de Hannah Arendt e os nossos países não são uma exceção à regra. No entanto, o texto é de grande importância para explorar algumas questões em Arendt que, apesar de ter continuidade, são menos desenvolvidos em seus outros livros. Nele, Arendt enfoca a dimensão instituinte da ação política revolucionária. Esse é um elemento essencial para temos uma visão mais completa do pensamento político da Hannah Arendt e pensamos as nossas realidades políticas da América Latina. Neste trabalho, então, oferecemos certos elementos de análise do pensamento político de Hannah Arendt como eles aparecem na sua obra Sobre a Revolução. Vamos enquadrar a nossa leitura entre duas interpretações que, na nossa opinião, são igualmente interessantes, muito influentes no contexto da América Latina, e que são referências essenciais para a compreensão da obra de Arendt, mas diferem quanto à interpretação dada ao seu pensamento político e, em particular, quanto ao local que as instituições políticas ocupam nele. Essas são as interpretações de Étienne Tassin sobre os paradoxos da revolução na obra de Arendt e de Margaret Canovan sobre o novo republicanismo arendtiano. Em seguida, vamos desenvolver algumas chaves para uma leitura própria de On Revolution entre as duas posições. Finalmente, vamos oferecer uma conclusão e trazer os pontos mais importantes do nosso argumento.
As narrativas entre o dito e o feito: Alberto Tavares Silva e sua inscrição na memória e na história do Piauí
Authors: Fontineles Filho Pedro Pio
Published: December 2017

FONTINELES, Cláudia Cristina da Silva. O Recinto do elogio e da crítica: maneiras de durar de Alberto Silva na memória e na história do Piauí. Teresina, EDUFPI, 2015. 543 p.
A obra-prima Os Maias de Eça de Queirós numa leitura cinematografada – olhares sobre a cultura lusitana
Authors: Sobral Filomena Antunes
Published: December 2017

Estabelecendo um percurso histórico que procura relacionar literatura e cinema, o texto propõe uma aproximação analítica à adaptação cinematográfica de Os Maias (realizada pelo diretor português João Botelho em 2014). Simultaneamente foca no caráter reflexivo e indagador que a arte pode assumir propondo o questionamento acerca das (des)continuidades possíveis entre o romance queirosiano do século XIX e a leitura filmica adaptada. Beneficiando historicamente de uma conexão dialogal com a literatura, o cinema é apontado como um campo fértil para promover dinâmicas de criatividade que permitem repensar o país no período histórico da contemporaneidade a partir de um monumento canónico.
Karl Marx: um balanço biográfico
Authors: Segrillo Angelo
Published: December 2017

Muitos balanços bibliográficos/teóricos foram feitos sobre o pensamento e obras de Marx, entretanto, nunca foi realizado um balanço biográfico sobre o pensador alemão, no sentido de um balanço das biografias que foram escritas sobre sua vida, independentemente de sua obra teórica. É este balanço inédito que é oferecido aqui. Serão examinadas as principais biografias de Marx, desde a primeira (surgida dois anos após sua morte) até as lançadas no século XXI. Procurar-se-á mostrar a evolução na qualidade deste tipo de trabalho, tanto no aspecto metodológico-formal como no aspecto de novas facetas factuais da vida de Marx sendo descobertas ao longo do tempo.
Report on the management of thrombocytopenia in obstetric patients: A retrospective study
Authors: Seifoleslami Mehri
Published: December 2017

Thrombocytopenia occurs to approximately 8%–10% of pregnant women and this condition is a notable source of morbidity and mortality during pregnancy. In the recent years, our comprehension of thrombocytopenia has progressed on pregnancy. Nevertheless, there has not been adequate information about thrombocytopenia outcomes in obstetric patients. With regard to this topic, we reviewed published reports as an update from the managements on these cases. Nevertheless, recommendations for management of delivery in obstetric women with thrombocytopenia are based on several hypotheses requiring critical analysis. For this cause, we reviewed the management of pregnant patients with thrombocytopenia treated over a period of 37 years.
Prevalence of gram-negative bacilli isolated from the equipment and surfaces in hospital wards of Golestan province, North of Iran
Authors: Ayatollahi Ali Asghar , Amini Abolfazl , Rahimi Somayeh , Takrami Saeid Rahbar , Darsanaki Reza Kazemi , Nezhad Muhammad Sadeqi
Published: December 2017

Nosocomial infections are one of the most common causes of death in hospitals. This study aimed to determine the prevalence of gram-negative bacilli isolated from the equipment in hospital wards of the Golestan province, in the year 2015. In this crosssectional study in 2015, 1980 samples from medical and nonmedical equipment and surfaces were collected from the wards of 13 teaching hospitals, in the Golestan province. Samples were inoculated into eosin methylene blue agar and blood agar culture media and isolated colonies were identified by standard biochemical tests. The obtained results were then analyzed using SPSS 22 software and χ2 test. Among 1980 isolated samples, 601 samples (30.35%) were infected with gram-negative bacilli while Enterobacter aerogenes (37.27%) was responsible for most of the contaminations. The highest rate of infection was observed in the intensive care unit (33.1%), and the highest level of contamination in the medical equipment was associated with laryngoscope and its blade (10.48%), as well as ECG sensor and its monitoring connector (6.65%). Meanwhile, phone (6.32%) and patients’ beds and linen (5.15%) had the highest level of contamination in the nonmedical equipment. Considering the high rates of gram-negative bacilli contamination in the hospital wards of the Golestan province, thorough hand washing as the main action for disinfection and sterilizing the equipment, as well as performing periodic cultivation alongside the use of standard guidelines for prevention and control of nosocomial infections, are recommended to reduce the level of contamination.
Az új orális antikoagulánsokkal történő kezelés laboratóriumi vonatkozásai
Authors: Bereczky Zsuzsanna , Oláh Zsolt , Ajzner Éva , Kappelmayer János
Published: December 2017

Abstract:

The introduction of novel oral anticoagulants (NOAC) have long been expected drugs and they quickly became used widespread as their clinical effectiveness was as good as, or even better than the previously used only oral anticoagulant drug, the coumarins. Thus, the direct thrombin inhibitor dabigatran and the activated factor X inhibitors (rivaroxaban, apixaban, edoxaban) have become the part of daily therapeutic practice. Their permeation was facilitated by the guideline which suggested that no laboratory monitoring was required during NOAC treatment and this was very convenient for both patients and doctors. The clinical experience obtained in the past years, however have proved that the ‘one size fits all’ view is oversimplified and there are numerous situations when the determination NOAC levels is unavoidable or highly recommended. This review discusses the laboratory aspects of NOAC treatment, primarily summarizing their effect on the screening tests and special assays of hemostasis and we also describe the correct methods to determine their plasma concentrations. Orv Hetil. 2017; 158(49): 1930–1945.
Using Computerized Bilingual Dictionaries to Help Maximize English Vocabulary Learning at Japanese Colleges
Authors: Loucky John
Published: December 2017

This study compares various computerized bilingual dictionaries (CBDs) for their relative effectiveness in helping Japanese college students at several language proficiency levels to access new English target vocabulary. The rationale of the study was based on several observations and research claims (Atkins & Knowles, 1990; Bejoint & Moulin, 1987; Laufer & Hadar, 1997) that bilingual/bilingualized dictionaries in general, and electronic dictionaries in particular, appear to be much more effective than monolingual book dictionaries for the acquisition of new L2. The author has been testing and analyzing various CBDs for several years and has recently devised a simple, yet practical dual assessment vocabulary evaluator (DAVE) to help more clearly define and test differences between both L1 and L2 mental lexicons and also between language learners' L2 receptive vocabulary and productive vocabulary (Loucky, 2001a). Computer technology has now made it possible, with the benefits of interactive processing and immediate feedback, to scan, pronounce, and translate vocabulary items. This paper examines Japanese college students' use of four kinds of CBDs for more rapid accessing and archiving of new L2 terms and recommends more informed integration of their use into a systematic taxonomy of vocabulary learning strategies for maximally effective instruction. It describes a comparative study of CBDs as they were used at three colleges in Kyushu, Japan from October 2000 to December 2001 and examines possible benefits that may accrue from their use.
Supporting Listening Comprehension and Vocabulary Acquisition with Multimedia Annotations
Authors: Jones Linda
Published: December 2017

This study extends Mayer's (1997, 2001) generative theory of multimedia learning and investigates under what conditions multimedia annotations can support listening comprehension in a second language. This paper highlights students' views on the effectiveness of multimedia annotations (visual and verbal) in assisting them in their comprehension and acquisition of vocabulary from aural texts. English-speaking college students listened to a 2 min 20 sec historical account in French presented by a computer program. Participants were randomly assigned to one of four listening treatments: the aural text (a) with no annotations, (b) with only verbal annotations, (c) with only visual annotations, and (d) with both visual and verbal annotations. For purposes of this paper, 20 students were purposively selected to participate in interviews. Overall, students remembered word translations and recalled the passage best when they had selected both verbal and visual annotations while listening. Students' voices reflected these results and revealed that they should have options for viewing material in both a visual mode and a verbal mode in a multimedia listening comprehension environment. This study provides qualitative evidence for a generative theory of multimedia learning that suggests that the availability and the choice of visual and verbal annotations in listening comprehension activities enhances students' abilities to comprehend the material presented and to acquire vocabulary.
Recent Developments in Technology and Language Learning
Authors: Zhao Yong
Published: December 2017

The purpose of this study is to assess the potential of technology for improving language education. A review of the effectiveness of past and current practices in the application of information and communication technology(ICT) in language education and the availability as well as capacities of current ICTs was conducted. The review found that existing literature on the effectiveness of technology uses in language education is very limited in four aspects: a) The number of systematic, well-designed empirical evaluative studies of the effects of technology uses in language learning is very small, b) the settings of instruction where the studies were conducted were limited to higher education and adult learners, c) the languages studied were limited to common foreign languages and English as a foreign or second language, and d) the experiments were often short-term and about one or two aspects of language learning (e.g., vocabulary or grammar). However the limited number of available studies shows a pattern of positive effects. They found technology-supported language learning is at least as effective as human teachers, if not more so.
Foreign Language Productivity in Synchronous Versus Asynchronous Computer-mediated Communication
Authors: Perez Luisa
Published: December 2017

This study investigates language productivity in a foreign language learner output obtained via two different modes of computer-mediated communication (CMC): asynchronous (email dialog journals) and synchronous (chatroom sessions). The research questions to be answered in the study were: (a) Which form of CMC, synchronous (chatroom activities) or asynchronous (email), would be more effective in increasing language productivity in foreign language learning? And (b) Which form of CMC would participants prefer? A within-subject design was used in the study with 24 participants who were studying first semester Spanish with one instructor. Participants emailed a dialog journal in Spanish to their instructor every Tuesday during the semester and they also attended the chatroom every Thursday to chat with their instructor and with each other in Spanish. Students met in the conventional classroom three times a week and via CMC on Tuesdays and Thursdays. The researcher tallied how many new vocabulary words participants produced in the email journals as opposed to new vocabulary words produced in chatroom sessions. (The researcher counted only those words that did not appear in the textbook or had been taught in class.) Results showed that there were no significant differences between the two CMC modes. However, a higher number of words were produced in the chatroom discussions than in the email messages. Fifty percent of the students preferred electronic mail and the other 50% were more inclined towards chatroom sessions. The author concluded that both techniques had benefits for vocabulary enrichment and productivity and that both tools enhanced the language acquisition process.
Single pile under vertical vibrations in cohesionless soil
Authors: Goit C. S. , Saitoh M.
Published: December 2017

The vertical response of a fixed-head floating single pile embedded in sand is obtained experimentally under 1g conditions. Specifically, pile head stiffnesses and axial strains generated along the pile length for a range of static and dynamic pile head loadings are measured. To account for the effects of soil non-linearity on the static response of the pile, a range of low- to high-magnitude static displacements is considered. Likewise, for the dynamic response, varying amplitudes of vertical harmonic accelerations for a wide range of frequencies are considered. Results obtained from the experiments under both the static and dynamic loading conditions indicate that the pile head stiffness is dependent on the direction of pile head loading – that is, whether the pile is pushed or pulled. To gain further insight into such direction-dependent pile head stiffness, three-dimensional non-linear finite-element analyses are carried out. Numerical results show very good agreement with the experimentally measured pile head stiffnesses. Axial strains generated along the pile length due to head loadings, on the other hand, depend on the amplitude of both the static and the dynamic loadings.
Experimental testing for Zarzis port sediments (Tunisia) in road materials
Authors: Zelleg Marwa , Said Imen , Hamdi Essaieb , Lafhaj Zoubeir
Published: December 2017

This study focused on the feasibility of Tunisian sediment reuse as new road material. Experiments were conducted to investigate sediment reuse as road material. Three mixtures (raw sediments, stabilised sediments with 3% lime and stabilised sediments with 3% cement) were studied with regard to their mechanical performances. The first part of this paper introduces the characterisation of Zarzis sediments. The second part describes the laboratory experiments and the followed methods. The third part is dedicated to the analysis of results. The originality of this work is the use of a minimum percentage of lime, which was determined experimentally. Based on environmental tests, Zarzis sediments were uncontaminated. Thus, they can be reused directly without a decontamination treatment process. Results show that humic compounds complicated sediment treatment with cement. Therefore, cement did not present an appropriate binder for stabilising and solidifying the investigated sediments. Based on mechanical results, a mixture with 3% lime can be used as new road material.
Rammed aggregate pier installation effect on soil properties
Authors: Saftner David A. , Zheng Junxing , A. Green Russell , Hryciw Roman , Wissmann Kord
Published: December 2017

This paper describes the changes in in situ index properties following installation of rammed aggregate piers in a loose sand deposit in New Madrid, Missouri, with a particular focus on the time-dependent strength gain, commonly called sand ageing, as indicated by increased cone penetration test (CPT) tip resistance and dilatometer test (DMT) indices. The method of disturbing the soil and the magnitude of disturbance significantly influence the magnitude of sand-ageing effects. This paper provides the first data on sand ageing following the installation of displacement rammed aggregate piers. In this study, CPT and DMT were performed both immediately before and after the installation of piers. Additionally, CPTs were performed 1 month following the installation of piers. The DMT horizontal stress index increased roughly 100% and the dilatometer modulus increased ∼200% in a loose clean sand layer immediately following the installation of the piers. The CPT tip resistance increased roughly 100% in this layer immediately following the pier installation and a further 33% in the month following the installation.
Implications of uncompacted packing density of aggregates in self-compacting concrete mix proportioning
Authors: Raj Smriti , Bharatkumar B. H. , Kumar V. Ramesh
Published: December 2017

This study forms part of ongoing research on sandwich panels by the authors’ research team at CSIR-SERC, India, where there is a demand for self-compacting concrete with a limit on aggregate of size up to 10 mm, and with approximate cube strength and slump flow in the ranges 45–50 MPa and 600–700 mm, respectively. These requirements are achieved using a packing density concept for aggregates. In self-compacting concrete, when the concrete has not been compacted or vibrated during and after pouring, the uncompacted packing density of aggregates determines most of the aggregate-related attributes of the concrete. To obtain the uncompacted packing density of the aggregates, existing theoretical models for binary combination of aggregate are extended to ternary combination and the model with least deviation from the experimental procedure is chosen for the mix proportioning of aggregates in the self-compacting concrete. The extended Toufar model is identified as giving better uncompacted packing density in agreement with the experimental study, and is used for the proposed mix proportion. In the proposed mix proportioning method, slump flow is achieved without compromising the cube strength by optimising the aggregate volume, binder combination and superplasticiser dosage.
Experimental study on the dynamic response of a gravity dam model with longitudinal joints
Authors: Tan Lili , Hu Xiao
Published: December 2017

A shaking table model test is conducted to study the dynamic response and failure mode of a 185 m high concrete gravity dam with longitudinal joints. Two longitudinal joints are provided in the dam model. A mortar mixture is used as the model material to satisfy the similarity requirements for the model test. The dynamic response and damage process of the dam are observed by inputting earthquake excitations with different ground peak accelerations (GPAs) and durations. It is observed that when the GPA is 5·32g (equivalent to 0·4g on the prototype) and the duration is 3·2 s, a crack appears at the top of the longitudinal joint that is close to the reservoir side and then extends to the slope of the downstream face. After 6·4 s, this joint is totally pulled apart and meets the crack that was previously formed. This study shows that when a strong earthquake occurs, the top of the longitudinal joint of the dam is more likely to suffer tensile damage, and the longitudinal joint will open because of the relatively low tensile strength. Based on the variations in strains, acceleration responses and dynamic characteristics, the possible crack location and damage process of the dam can be predicted.
Clinical Significance of the KRAS Mutation
Authors: Beganovic Sead
Published: December 2017

The challenge of translational medicine is to translate very complex scientific data into the clinical setting so that medical management can be better guided towards the ultimate goal of better patient outcome. Physicians now have the opportunity to use specific biomarkers to personalize therapeutic options in various settings. Recent research has demonstrated that presence of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation may directly influence medical decisions in patients with colon and lung cancer.Use of KRAS oncogene as a selection marker for specific treatment is a good example of individualized medicine approach to cancer treatment.
Extra-Articular Manifestations of Seronegative and Seropositive Rheumatoid Arthritis
Authors: Sahatçiu-Meka Vjollca , Rexhepi Sylejman , Manxhuka-Kërliu Suzana , Rexhepi Mjellma
Published: December 2017

Although considered a “joint disease,” rheumatoid arthritis is associated with the involvement of extra-articular manifestations. The aim of the study is the investigation and comparison of frequency and type of extra-articular manifestations in a well defined community based cohort of patients with seropositive and seronegative rheumatoid arthritis. Using the ACR (1987) criteria for rheumatoid arthritis, patients have been classified into the 2nd and 3rd functional class (ARA). The studied group consisted of 125 seronegative patients with titters lower than 1:64 as defined by Rose-Waaler test, whereas the control group consisted of 125 seropositive patients with titters of 1:64 or higher. All patients were between 25-60 years of age (Xb=49,96), with disease duration between 1-27 years (Xb=6,41). In order to present the findings of the study, the structure, prevalence, arithmetic mean (Xb), standard deviation (SB), variation quotient (QV%) and variation interval (Rmax-Rmin) have been used. Probability level has been expressed by p<0,01 and p<0,05. Correlation between the number of extra-articular manifestations and duration of the disease has been calculated by means of Pearson linear correlation. Higher presence of diffuse lung fibrosis, central and peripheral nervous system damages have been confirmed in the seropositive group, and osteoporosis in the seronegative; however, no statistical difference has been found. In extra-articular manifestations, “rheumatoid core” in the seropositive subset (χ2=4,80, p<0,05) presented significant statistical difference. Rheumatoid nodules were more frequent in seropositive subset (12%:16%), in both sexes; however, they were not of significant statistical difference. Neuropathy and lung diseases were also frequently present in seropositive group, but no statistical difference has been found regarding the statistical difference. Longer duration of the disease resulted in an increase of the number of extra-articular manifestations. Calculated linear correlation by Pearson, resulted as positive and high correlation in total (r=0,36, p<0,01), and for groups [(r=0,52, p<0,01) seronegative, (r=0,25, p<0,01) seropositive], nevertheless no significant statistical difference was found regarding the serostatus. In conclusion, extra-articular manifestations are more frequent in the seropositive patients. The longer the duration of the disease the larger the number of extra-articular manifestations. Differences with regard to sero-status and sex, with some exceptions, are not observed.
АДАПТИВНАЯ МОДЕЛЬ БИНАРНОГО ВЫБОРА И ВОЗМОЖНОСТИ ЕЕ ПРАКТИЧЕСКОГО ИСПОЛЬЗОВАНИЯ
Authors: Davnis V. V. , Yurova Y. A.
Published: December 2017

Цель: построение адаптивной модели бинарного выбора на основе нового подхода к реализации адаптивных принципов. Обсуждение: принципы адаптации, перекочевав из живой природы в науку, технику, теорию и практику управления, показывают абсолютную универсальность. Трудно назвать область человеческой деятельности, в которой эти принципы нельзя было бы использовать. Особое место они занимают в моделировании экономических процессов. Механизм, с помощью которого осуществляется практическая реализация принципов адаптации, основан на экспоненциальном сглаживании. Процедура экспоненциального сглаживания оказалась столь удачной, что ее использовали даже при объяснении смысла гипотезы адаптивных ожиданий. В результате применения этой процедуры происходит затухание более ранних тенденций и закономерностей, что естественным образом обеспечивает доминирование закономерностей, демонстрируемых последними наблюдениями. Возникает закономерный вопрос:  действительно ли процедура экспоненциального сглаживания представляет собой единственный способ, с помощью которого удается осуществить плавную замену старых тенденций новыми. В исследовании предлагается не затухание более ранних тенденций, а усиление вновь нарождающихся. Понятно, что усиление новых тенденций автоматически приводит к относительному снижению значимости старых. Фактически достигается тот же самый эффект. Результаты: предлагаемый способ построения адаптивного механизма назван степенным сглаживанием, что, по мнению авторов, подчеркивает аналогичность его предназначенности с экспоненциальным сглаживанием. Но в отличие от экспоненциального сглаживания степенное сглаживание применяется для построения нелинейных регрессионных моделей, коэффициенты которых оцениваются с помощью метода максимального  правдоподобия, специфика которого учитывается экспоненциальным сглаживанием. Изложены детали применения этого подхода дял построения адаптивной модели бинарного выбора.
TruSeq RNA Preparation with Modification for Four Rounds of Poly-A Selection v1
Authors: Daniel Richter Dr.
Published: December 2017

March, 2012; based on sample preparation guide v2, catalog # RS-930-1021, part # 15026495 Rev. A, August 2011 Modifications: samples in PCR tubes (because a plate/seal will not be used, some numbered steps are skipped); include two rounds of poly-A selection (with two separate sets of beads); repeat clean-up step after PCR to remove additional adapters; elute with 1.5 ul less volume off of beads (to leave 1 ul behind, not 2.5 ul)
RNAqueous with TURBO DNA-free and SUPERase-In v1
Authors: J. Richter Daniel
Published: December 2017

Daniel Richter, Nov 29, 2011 based on RNAqueous May 29, 2008 protocol revision C, TURBO DNA-free June 9, 2009 protocol 1907M revision F
Lysis Buffer for Phenol/ chloroform genomic DNA extraction (makes 20 mL of buffer) v1
Authors: J. Richter Daniel
Published: December 2017

Yeilds 20 mL of Lysis buffer to be used in Phenol/ chloroform genomic DNA extrations.
Glutathione-S-Transferase (GST) activity assay for copepod samples v1
Authors: A. Vuori Kristiina , Kanerva Mirella
Published: December 2017

Total GST activity measurement from copepod (Limnocalanus macrurus, Acartia sp., Eurytemora affinis, Temora longicornis, Calanus sp., Eubosmina maritima, Limacina helicina) homogenates.
Genotyping of rs3824662 polymorphism in GATA3 gene by allele-specific PCR v1
Authors: Huda Nafiul , Ismail Hosen Md. , Kumar Sarkar Pankaj , Mahbub Hasan A.K.M. , Nurun Nabi A.H.M.
Published: December 2017

To amplify the target regions of GATA3 for studying rs3824662 polymorphism, a web-based primer designing tool available at http://bioinfo.ut.ee/primer3-0.4.0 facilitates crafting the set of outer primers [forward outer primer: 5’-TTGCAAATGGAAGAGGGTCT-3’ and reverse outer primer: 5’-ACCCTGCAAATGAGAGGAAA-3’] and inner primers [G specific primer: 5’-TGAGATTAAACACAAACACGtTG-3’ and T specific primer: 5’-CTGAGATTAAACACAAACACGaTT-3’] to perform allele-specific PCR that specifically amplify the GATA3 gene. G/T allele-specific primer is very sensitive and binds only with the DNA fragments containing G/T nucleotide template DNA. Forward outer and reverse outer primers will amplify a specific 691 base pair region of GATA3. This 691 base pair region contains the desired polymorphic site of interest. Allele-specific primers produce 506 bp products upon the presence of either a G allele or T allele. PCR reaction in a total volume of 15 μL with an initial denaturing step of 5 min at 95°C, followed by 40 cycles of 30 s at 95°C, 45 s at 55°C, and 1 min at 72°C, and a final extension step of 5 min at 72°C will produce better reproducible result. The reaction mixture contains both forward outer and reverse outer primers and contains either the G allele-specific forward inner primer or the T allele-specific forward inner primer. Primer concentration used was 200 nM each. When the G allele is present in a specific DNA sequence, only the 506 base pair band will be found upon gel electrophoresis of PCR amplicons with the G allele-specific primer. In this case, no such 506 base pair band will be obtained upon gel electrophoresis with the T allele-specific primer. On the other hand, for mutant TT genotypes, the opposite phenomenon will occur when the T allele is present, which will be reflected by the presence of the 506 base pair DNA band. In the case of the heterozygous genotype (GT), both inner primers for G and T alleles will bind with specific DNA sequences to produce 506 base pair bands.
Acceptance of Different Design Exergames in Elders v3
Authors: Chen Chih-Kuang , Tsai Tsai-Hsuan , Lin Yin-Chou , Lin Chung-Chih , Hsu Su-Chu , Chung Chia-Ying , Pei Yu-Cheng , M K Wong Alice
Published: December 2017

For promoting the successful aging of elderly residents of Chang Gung Silver Village in Taiwan, five interactive exergames were developed to promote the well-being of the elderly. The exergames included both physical games and cognitive games and were implemented using various computer-based technologies in the Chang Gung Silver Village. The exergames were trialed by 39 elderly residents (15 male, 24 female; mean age 79.5 ± 17.5 years) of Chang Gung Silver Village. Following the trials, the participants were requested to complete a Technology Acceptance Model 2 (TAM2) questionnaire. The results showed that the perceived playfulness and perceived usefulness of the exergames were significantly related to the users’ usage behavior and intention to use for both the physical games and the cognitive games. However, a relationship between the output quality of the game and the usage behavior was apparent only in the case of the cognitive exergames. Finally, the impact of social influence on the intention to use and the usage behavior was more pronounced for the physical exergames. Overall, the results revealed that the acceptance of exergames by the elderly depends not so much on the awareness of fun in using the game, but the perceived usefulness of the related physical and cognitive abilities.
A Review of Studies on Languaging and Second Language Learning (2006-2017)
Authors: Niu Ruiying , Li Lijia
Published: December 2017

Since Swain postulated the concept “languaging” in 2006 to capture the role of language production in second language (L2) learning, a growing body of empirical studies has been conducted on languaging. However, little research has reviewed these studies. The present paper reviews 15 empirical studies that were conducted over the past decade on languaging in L2 learning, followed Vygotsky’s socioculutral theory of mind, and directly took languaging as the treatment or part of the treatment. We distinguished task-prompted and teacher-imposed languaging in the paper. All studies reviewed focused on teacher-imposed languaging. On the basis of reviewing the foci and findings of the studies, we offer our critical comments and recommendations for future research.
A Multimodal Discourse Analysis of a Propaganda Image—Taking the Official Homepage of One Belt and One Road Economic and Cultural Development Center as an Example
Authors: Wang Qing , Zhang Xiaorong
Published: December 2017

Nowadays, China is overwhelmed by the thoughts of “One Belt and One Road Economic and Cultural Development”, which was proposed by President Xi Jinping in 2013. That is the main reason why we choose the propaganda image of One Belt and One Road Economic and Cultural Development Center, an official homepage (http://www.oborecdc.org), as research target. And we call it “One Belt and One Road Multimodal Discourse” for convenience in this paper. This paper, applying Kress & van Leeuwen’s Visual Grammar theoretical framework, is studied with qualitative analysis from three aspects, which are representational function, interactive function and compositional function. Besides, based on the specific social and cultural context, the paper gives a specific analysis of how different semiotic resources work together to produce a integrated meaning system. It is founded that: 1) For representational function, “One Belt and One Road Multimodal Discourse” belongs to a conceptual image, which includes the classification process and symbolism process; 2) As for interactive function, the designer builds the interactive relationship with viewers by using frontal-horizontal angle of view; 3) In composing the whole image, due to the different value of information, the designer composes the image by using different location, size and color. Specifically speaking, the central writing system belongs to the main mode, while the other visual modes mainly complement or highlight it in order to effectively realize the total meaning of the whole image; 4) Based on specific social and cultural context, the designer combines the historical symbol-Silk Road and cultural symbol-Chinese Red with realistic Symbol-globalization, to realize the complete meaning of “One Belt and One Road Multimodal Discourse”. It is theoretically and practically significant to do this research. Theoretically speaking, it enriches the relative research on static multimodal discourse analysis. In practice, it helps viewers to understand the implied meaning of “One Belt and One Road Multimodal Discourse” better.
CROSS-BORDER ASPECTS OF SOCIO-ECONOMIC CONVERGENCE OF REGIONS: THE EUROPEAN INTEGRATION CONTEXT
Authors: Kutsab-Bonk К.
Published: December 2017

The current stage of European integration of Ukraine is determined by the intensification of partnership relations with the EU in the all planes of socio-economic interaction. In particular, it concerns development of cross-border cooperation and capacity of cross-border markets potential. Because of that the problems of cross-border cooperation between Ukraine and EU today becomes more urgent.
One of the key criteria of successful cross-border cooperation between Ukraine and the EU is the alignment of proportions of economic development on different sides of the border. In this sense, an important indicator of the quality of transboundary cooperation is cross-border convergence of regions. It reflects the socio-economic effect from implementation of transboundary projects and plays an important role in the context of leveling the existing threats and challenges of cross-border economic, social and information security. Alignment the quality of life and standards of economic development on different sides of the border eliminates a number of risks associated with the spread of destructive forms of cross-border cooperation, such as smuggling at cross-border markets, illegal labor migration, corruption at the border crossing etc.
The priority instrument of transboundary convergence spreading is the institutionalization of cross-border space. First of all it concerns the formation of the legal support, oriented to the deployment of convergent processes. In addition, institutionalization concern such key elements of transboundary cooperation as the functioning of cross-border institutions, the eradication of transboundary institutional dysfunction, and a decrease the level of transaction costs of participants of cross-border markets.
Important way to stimulation of cross-border convergence is the formation of joint cross-border brands for each of cross-border regions between Ukraine and the EU. On this basis, should be developed appropriate strategies for development of cross-border markets. Such strategies should ensure the maximum use of socio-economic potential of corresponding cross-border regions, and also should form grounds for the spread of convergent processes within them.
INTERNATIONAL TOURISM IN FOREIGN POLICY STRATEGY OF THE REPUBLIC OF CUBA
Authors: Parfinenko A.
Published: December 2017

The article investigates the role of international tourism in formation of the foreign policy interaction priorities of the Republic of Cuba. The author has carried out retrospective analysis of the dynamics and spatial structure of tourist flow into the country in the second half of the XX – early XXI century as well as has found significant variations in the time series and defined their correlation with changes in the foreign policy strategy of Cuba.
It has been established that during the term of the US embargo against Cuba, the United States failed to isolate the country from the global network of tourist flows with relevant economic and geopolitical impact. The author has established that the tourist factor contributed both to the introduction of market economy elements and the preservation of the Castro regime, influenced the transformation of the socio-economic structure of Cuban society and forced Havana to intensify foreign policy contacts with the USA.
The paper characterizes the current phase of foreign policy interaction of Cuba with the USA, which has marked the liberalization of economic life and another notable surge of tourist visits to the country. The article reveals the constructive role of tourism in Cuba as the practice of social interaction that helps to restore trust between peoples even despite the political position of each party. This objectively existing reality opens space for the complete abolition of embargo and deepening dialogue with the USA.
The author claims that international tourism in Cuba has played an effective role in the transformation of state foreign policy vector, has become an important component of globalization practice that contributed to the support of foreign economic and foreign policy relations.
It has been concluded that in the context of globalization the given growing impact of international tourism in the resolution of world politics issues is an enduring trend associated with the expansion of non-state international entities range.
МН17 TRAGEDY: RUSSIA IS NOT INVOLVED, REALLY?
Authors: Zadorozhnii O.
Published: December 2017

Examines the arguments used by Russia to accuse Ukraine in disaster of Malaysian Boeing 777 that occurred on July 17, 2014. In particular, the article analyzes the following lines of arguments developed by the representatives of the Russian government and doctrine: responsibility of the state in whose territory the crime has been committed; the campaign to discredit the investigation into the incident aimed at whitewashing Russia and at deflecting suspicion and accusations from Russia; criticism of the ideas and procedures for the establishment of an international tribunal to investigate crimes associated with the downing of MH17. The author points to the absurdity, contradictions of the positions of the Russian authorities and the doctrine of international law in terms of international law, and in terms of the facts. In his turn, the author qualifies accident in terms of international law against the general context of the war of aggression of the Russian Federation against Ukraine. The author also argues in favor of a qualified international investigation into the accident and the creation of an international tribunal to prosecute the perpetrators of the tragedy.
Influence of L-Nω-nitroarginine methyl ester and sodium nitroprusside in vitro on the oxidative modification of rat lysosome proteins
Authors: Fomina M A , Kudlaeva A M , Isakov S A , Ryabkov A N
Published: December 2017

Aim. To investigate in vitro effects of 5 mM L-Nω-nitroarginine methyl ester and 0.1 mM sodium nitroprusside on oxidative modification of lysosomal proteins of liver of intact sexually mature female rats of Wistar line. Methods. In the control groups in vitro incubation of isolated lysosomes in the isolation medium for 1, 2 and 4 hours was carried out. Experimental groups were incubated similarly in solutions of 5 mM L-Nω-nitroarginine methyl ester and 0.1 mM sodium nitroprusside. Protein oxidative modification was measured in sedimentary fraction according to R.L. Levine’s method in E.E. Dubinina’s modification. Reserve-adaptive capacity was calculated as the difference between total area under the curve of carbonyl derived proteins after metal-catalyzed oxidation (taken as 100%) and spontaneous oxidation, expressed as a percentage. Results. After 4-hour in vitro incubation 5 mM L-Nω-nitroarginine methyl ester was found to statically significantly increase the total level of protein oxidative modification compared to the control group by 2.41 times and to reduce reserve-adaptive capacity by 4.96 times, and 0.1 mM sodium nitroprusside increases the total level of protein oxidative modification compared to the control group by 2.05 times and reduces reserve-adaptive capacity by 1.56 times. One of the possible mechanisms of this phenomenon may be the reduced activity of lysosomal proteinases. 2-hour and 4-hour in vitro incubation of lysosomes in 5 mM L-Nω-nitroarginine methyl ester is accompanied by an increase of secondary markers of the ratio of protein oxidative modification relatively to 1-hour exposure by 1.18 times and 1.35 times, respectively. At 1-hour in vitro incubation in 0.1 mM sodium nitroprusside, increase of secondary markers of protein oxidative degradation by 1.64 times occurs. Conclusion. The in vitro effect of 5 mM -Nω-nitroarginine methyl ester and 0.1 mM sodium nitroprusside results in visible changes of oxidative modification of rat liver lysosomal proteins.
On the question of surgical treatment of advanced oral and oropharyngeal cancer
Authors: Svetitskiy P V , Aedinova I V , Volkova V L
Published: December 2017

Aim. To improve the results of treatment of patients with advanced oral and oropharyngeal cancer. Methods. To achieve the aim, studies were carried out on 30 patients with advanced cancer of the oral cavity and oropharynx. An operation was developed that involved modified mandibulotomy with vertical slanting jaw incision and separation of its fragments, and radical removal of the tumor under visual and manual control, which was performed in 14 patients (study group). Postoperative osteosynthesis was performed by fixing jaw fragments with a titanium miniplate. For comparison, 16 patients were operated in a traditional way (control group), in which the cheek was dissected up to the projection of the mandible branch, the tongue was stitched and stretched, the tumor process was removed. Results. Use of the proposed method provides visibility of the tumor process, its boundaries, topography of the internal carotid artery, facilitates radical removal of the tumor. The event-free 2-year survival in the study group was 43±7.2%, in control group - 25±6.0%. The median event-free survival in the study group was 22 months, in control group - 14 months. Conclusion. The proposed method of surgery provides radical removal of the tumor while monitoring the internal carotid artery, and in the post-operative period - rehabilitation of the resected organs of the oral cavity.
Individual prognosis of urolithiasis, benign hyperplasia and prostate cancer development based on medical and social risk factors
Authors: Zolotukhin O V
Published: December 2017

Aim. To predict the risk of developing urolithiasis, benign hyperplasia and prostate cancer on the basis of mathematical modeling on individual medical and social factors. Methods. Prognostic evaluation of the risk of studied pathology development based on 30 medical and social factors was performed. Representive samples of patients with verified diagnosis of urolithiasis, benign prostatic hyperplasia and prostate cancer (study groups) as well as individuals without these diseases (comparison group) constituted the material of the study. The study protocol included preparation of primary data, transformation of qualitative data into numerical form, logistic regression modeling of risk, verification of models. Risk prediction itself was performed with the use of reasonably chosen methods of mathematical modeling (a priori ranging, regression analysis and discrete correlation pleiades aimed at minimizing the informative parameter redundancy). The developed models were verified by passive experiment method. Results. Based on long-term empirical observation the scientific hypothesis was proposed that urolithiasis, benign hyperplasia and prostate cancer development is more probable in patients with certain risk factors. To prove or reject the proposed hypothesis, the analysis of prognostic informativeness was performed for 30 factors suspected to cause the studied pathology development. It was performed with the use of logistic regression models. As a result among the studied working and living conditions of urological patients prognostically significant factors were determined. Developed on their basis (and subsequently verified) models allowed mathematically evaluating real risk of the studied urologic diseases development. Conclusion. Development of the models of individual risk of the studied nosologic forms development based on the analysis of medical and social factors is principally possible; verification of the developed models confirms their practical applicability and proves the principal feasibility of the proposed approach.
Evaluation of the syndrome of functional deficit in elderly with non-oncological pathology
Authors: Ponomareva I P
Published: December 2017

Aim. Comparative analysis of the profile of integral functional disorders and the degree of their deficit in elderly patients after stroke and in chronic heart failure functional class III-IV. Methods. Physical exam and interviews were used during comprehensive geriatric assessment with the analysis of the degree of functional disorders according to PULSES Profile scale and the degree of asthenia in the elderly. Results. The analysis of the degree of functional disorders in elderly and senile patients showed the diversity of issues that should be considered when providing medical and social care. In a moderate functional deficit in patients after stroke emotional and intellectual disorders prevailed - 47.2±0.1 cases, as well as upper extremities dysfunction - 29.9±0.2, and lower extremities dysfunction - 27.6±0.2. In severe heart failure inability to control excretory functions is predominant - 14.6±0.2 patients. Severe functional disorders prevailed in patients with consequences of stroke, which manifested as upper extremities dysfunction - 21.3 cases; lower extremities dysfunction - 22 cases; in severe heart failure communication disorders were prevalent - 6.4 cases. Conclusion. The more severe degree of functional deficit correlating with a high need for palliative medical and social care was observed more frequently in patients after stroke with prevailing upper and lower extremities dysfunction, while in chronic heart failure functional class III-IV communication disorders were predominant.