bluuebunny/crossref_metadata_2025 huggingface dataset:
A study of the effectiveness of a detergent-based California mastitis test (CMT), using Ethiopian and Nigerian domestic detergents, for the detection of high somatic cell counts in milk and their reliability compared to the commercial UK CMT
Authors: Rust Jack D. , Christian Michael J. , Vance Ciara J. , Bolajoko Muhammed B. , Wong Johanna T. , Suarez-Martinez Jeimmy , Allan Fiona K. , Peters Andrew R.
Published: September 2021

Background:  The California mastitis test (CMT) is a simple cow-side indicator of the somatic cell count (SCC) in milk, providing a useful tool in identifying cases of subclinical mastitis in cattle. Mastitis, and in particular subclinical mastitis, is a major concern in Ethiopia and Nigeria, yet detection is challenging due to cost and access to commercial CMT reagents.

Methods: Commercially available domestic detergents from Ethiopia and Nigeria were compared (n = 3 for each country) with the UK commercial CMT reagent in their ability to detect high SCC (>400,000 cells/ml milk).  Sensitivity and specificity of the CMT test were calculated for the different detergents and positive and negative predictive values were established.

Results:  The average sensitivities of the tests ranged from 28-75% for the Ethiopian detergents and 68-80% for the Nigerian detergents, compared to 76% for the UK domestic detergent.  Test specificities were 84-98%, 93-97% and 96%, respectively.

Conclusions:  Overall, the detergents demonstrated higher specificity than sensitivity.  Nigerian detergents performed better than the Ethiopian products, however, the study identified suitable domestic detergents from both Ethiopia and Nigeria, comparable to the UK commercial CMT reagent, and we recommend their use as alternative CMT reagents for livestock-keepers to aid in cost-effective diagnosis of mastitis.
ELVIRA NOTARI. UNOS OJOS NAPOLITANOS DETRÁS DE LA CÁMARA.
Authors: Cruzado Ángeles
Published: September 2021

No son pocas las mujeres que, a lo largo de la historia del cine, se han lanzado a la dirección de filmes, y entre ellas destacan especialmente algunas pioneras que, en las primeras décadas del siglo XX, hicieron notables contribuciones a la industria cinematográfica, aunque no por ello han sido reconocidas como se merecen. En Italia podemos mencionar a la napolitana Elvira Notari, que creó su propia productora – Dora Film – y realizó más de cien filmes de forma artesanal, con la colaboración de su marido y sus hijos. Sus películas, inspiradas en la cultura popular napolitana o en sucesos de crónica social, buscaban la identificación del espectador. Realizó también un número importante de documentales por encargo de los inmigrantes italianos en América, que podían así entrar en contacto con su cultura de origen.
USOS Y ABUSOS DE LOS DISCURSOS DE GÉNERO EN LOS CONTEXTOS BÉLICOS: UNA APROXIMACIÓN FEMINISTA A LA REPRESENTACIÓN DE LAS MUJERES AFGANAS EN LOS MEDIOS DE COMUNICACIÓN.
Authors: Reigada Olaizola Alicia
Published: September 2021

En los últimos años, la situación de las mujeres en los países arabo-musulmanes ha comenzado a ocupar el centro de muchos de los discursos y planes de intervención elaborados desde organismos y Estados occidentales. En este trabajo analizaremos la representación de la mujer afgana en los medios de comunicación en contextos de guerra. Para ello recurriremos a los instrumentos teórico-metodológicos que nos ofrece el análisis crítico del discurso y su combinación con las aportaciones realizadas desde el pensamiento feminista
LA IGUALDAD DE OPORTUNIDADES EN LA NUEVA CONSTITUCIÓN EUROPEA.
Authors: Castillo Cinta
Published: September 2021

La igualdad entre hombres y mujeres es un Derecho fundamental que aparece en la nueva Constitución europea. En este estudio se recogen los diferentes artículos de este documento de la Unión Europea que dan prueba de la legalidad de igualdad de oportunidades entre ambos sexos.
Real Effects of Tax Uncertainty: Evidence from Firm Capital Investments
Authors: Jacob Martin , Wentland Kelly , Wentland Scott A.
Published: September 2021

This paper examines whether tax uncertainty can alter investment decisions, focusing primarily on the timing of large capital investments. Empirically, we exploit the staggered implementation of Schedule UTP, a discrete policy change expected to increase tax uncertainty, finding that, on average, firms responded by delaying large capital investments. This effect is stronger among firms at which the policy treatment is particularly germane, that is, for firms with more material UTBs or with low-to-moderate quality public accounting information. We also test the underlying mechanism, finding that managers buffer against higher tax uncertainty with cheaper sources of financing (cash) and that the investment effect is concentrated among financially constrained firms. The results show that Schedule UTP also reduces the sensitivity of investment to growth opportunities (investment-Q sensitivity) in line with a higher hurdle rate for firms facing higher tax uncertainty.

This paper was accepted by Brian Bushee, accounting.
Introducing the new Chronic Oedema Wet Leg Pathway
Authors: Thomas Melanie , Morgan Karen , Lawrence Paula
Published: September 2021

Reticence to apply compression therapy has been widely observed in clinical practice, compounded by an absence of evidenced-based pathways for application of prompt compression prior to measuring ankle brachial pressure index (ABPI). Importantly, delaying compression therapy for patients with chronic oedema and lymphorrhoea causes many avoidable complications. In 2017, Lymphoedema Network Wales (LNW) developed an evidenced-based pathway to improve the management of chronic oedema and wet legs (lymphorrhoea) for community nurses. During the past 4 years, the Chronic Oedema Wet Leg Pathway has been presented, published and used internationally, as well as being translated into different languages. It is commonly used in community nursing Teams as an evidenced-based document. However, like all documents and guidelines, when more evidence becomes available, the pathway needs updating. Therefore, this clinical focus article will present the new and enhanced Chronic Oedema Wet Leg Pathway, introducing a new level four compression section, which increases the layers of compression bandaging for patients with venous insufficiency or who are morbidly obese.
Reflections on lymphoedema deployment into community services during the pandemic
Authors: Allen Stephanie , Morgan Karen
Published: September 2021

During the second wave of the COVID-19 pandemic, district nursing teams were overwhelmed with their caseload due to the palliative care needs of their patients. This led to patients with wet legs and chronic wounds deteriorating due to staffing levels. Therefore, the Swansea Bay University Health Board and Lymphoedema Network Wales teams redeployed two working time equivalents (WTE) into the community to take over the management of these patients with chronic wounds for 4 months. The clinicians came from a variety of different backgrounds, including nursing, physiotherapy, emergency medicine and occupational therapy. Between the teams, 866 visits were carried out over the 4-month period, where patients' compression therapy was altered to promote healing and reduce oedema. At the end of the 4-month period, 21% of the patients were discharged off the district nursing caseload completely, while of the 60% who were still active caseload patients, 35% were in increased compression and 20% had reduced need for visits.
Head and neck lymphoedema—research challenges during the COVID-19 pandemic
Authors: Pigott Amanda , Brown Bena , Trevethan Megan , Porceddu Sandra , McCann Andrew , Pitt Rachael , Nixon Jodie
Published: September 2021

Management of secondary head and neck lymphoedema has undergone little research investigation. Its treatment is time and labour intensive and involves multiple therapeutic modalities without a clear understanding of which is most effective. This study aimed to determine the feasibility of a randomised controlled trial comparing two therapeutic modalities to manage head and neck lymphoedema. The secondary objective was to evaluate the clinical effects of these treatments. Participants were randomised to receive treatment with manual lymphatic drainage or compression over 6 weeks, with the primary outcome—percentage tissue water—measured 12 weeks after treatment. Six participants were recruited until the study was ceased due to restrictions imposed by the COVID-19 pandemic. Some 86% of required attendances were completed. Percentage tissue water increased in all participants at 12 weeks. No consistent trends were identified between internal and external lymphoedema. The small number of people recruited to this study informs its feasibility outcomes but limits any conclusions about clinical implications.
Technology Anxiety and its Impact on E-Learning System Actual Use in Jordan Public Universities during the Coronavirus Disease Pandemic
Authors: Alkhawaja Maha Ismail , Halim Mutia Sobihah Abd , Afthanorhan Asyraf
Published: September 2021

During the Coronavirus disease (COVID-19) pandemic, universities were obligated to transform from traditional classroom teaching environments to virtual ones. This sudden transformation highlighted the issue of low e-learning system usage amongst instructors of humanity faculties in Jordan's public universities. This study empirically investigated the moderating impact of technology anxiety on the relationship between the instructor's self-efficacy and the e-learning system's actual use to contribute to solving the problem. A survey was distributed to 468 instructors to test the theoretical framework, which yielded 285 valid and complete instruments analyzed using Structural Equation Modeling (SEM). Results showed the positive direct effect of self-efficacy on actual use. Furthermore, the level of technology anxiety moderated the relationship. Instructors with low technology anxiety showed a higher level of e-learning system actual usage than those with a high anxiety level. To improve the use of e-learning systems, top management must understand the fundamental role of compulsory training as the Covid-19 pandemic, and the instructor's confidence must be increased by providing training and support.
The Impact of the COVID-19 Pandemic on Online Learning in Higher Education: A Vietnamese Case
Authors: Le Duc-Long , Giang Thien-Vu , Ho Dieu-Khuon
Published: September 2021

The article mentions the impact of the Coronavirus disease (COVID-19) pandemic on online learning in Vietnamese higher education in 2020. This is a qualitative case study, by using in-depth interviews to explore the changes in the perception, methods, and orientation of online learning of students and lecturers at a key pedagogical university when experiencing the three COVID-19 outbreaks in Vietnam. The findings show that the COVID-19 pandemic has a positive impact on the developmental orientation of online learning at the Vietnamese higher education level. Even though at the time of an outbreak, opposition and dissatisfaction with online learning occurred; but through the three outbreaks, together with the efforts of lecturers and students, online learning in Vietnam has recorded remarkable achievements. This is a prerequisite for the development of online education and the innovation of digital technology in education.
Inclusive Pedagogical Practice as a Predictor of Quality Early Childhood Education
Authors: Visković Ivana
Published: September 2021

The quality of the educational process within the humanistic concept and holistic-developmental approach is interpreted as the optimal adaptation to the individual needs and abilities of children, while inclusiveness presupposes equal inclusion and participation of all children. This article explores the opinions of teachers as bearers of pedagogical-educational process. The aim of this research was to determine how much importance teachers attach to certain dimensions of the educational process, and the procedures of inclusive practice. Empirical research included teachers in 5 preschool institutions (N=146). The research instrument was constructed based on relevant literature. Teachers in this sample recognize the importance: of individualized support to all children; of respecting the diversity; of collaboration with parents, and personal professional development. At the same time, the level of formal education and in-service teacher training is positively correlated with the assessment of importance towards child-oriented practice, and respect for diversity. Teachers with a higher level of education significantly value the importance of additional vocational training in the field of developmental and social risks, the use of community resources, and involvement of parents in planning individual support for children.
Obituary: Daniel Fritschy (1947–2021)
Authors: Hoffmeyer Pierre J.
Published: September 2021

EFORT Open Rev 2021;6:823-824. DOI: 10.1302/2058-5241.6.212000
Plastic embedding for precise imaging of large-scale biological tissues labeled with multiple fluorescent dyes and proteins
Authors: Ren Miao , Tian Jiaojiao , Sun Qingtao , Chen Siqi , Luo Ting , Jia Xueyan , Jiang Tao , Luo Qingming , Gong Hui , Li Xiangning
Published: September 2021

Resin embedding of multi-color labeled whole organs is the primary step to preserve structural information for visualization of fine structures in three dimensions. It is essential to study the morphological characteristics, spatial and positional relationships of the millions of neurons, and the intricate network of blood vessels with fluorescent labels in the brain. However, the current resin embedding method is inadequate because of incompatibilities with fluorescent dyes, making it difficult to reconstruct a variety of structures for the interpretation of their complex spatial relationships. We modified the resin embedding method for large biological tissues labeled with multiple fluorescent dyes and proteins through different labeling strategies. With TrueBlack as the background fluorescence inhibitor in the glycol methacrylate (GMA) embedding, we referred to the method as GMA-T (Glycol methacrylate with TB). In the GMA-T embedded mouse brains, structures labeled with fluorescent proteins and dyes were visualized in millimeter-scale networks with sub-cellular resolution, allowing quantitative analysis of different anatomical structures in the same brain, including neurons and blood vessels. In combination with high-resolution whole-brain imaging, it is possible to obtain a variety of fluorescence labeled structures in just a few days. We quantified the distribution and morphology of the tdTomato-labeled vasoactive intestinal polypeptide (VIP) neurons and the BSA-FITC labeled blood vessels in the same brain. These results demonstrated that VIP neurons and blood vessels have their own unique distribution patterns and morphological characteristics among cortical regions and different layers in cerebral cortex, and there was no significant correlation between VIP neurons and vessels. This approach provides a novel approach to study the interaction among different anatomical structures within large-volume biological samples labeled with multiple fluorescent dyes and proteins, which helps elucidating the complex anatomical characteristics of biological organs.
Non-line-of-sight optical communication based on orbital angular momentum
Authors: Liu Zhanwei , Huang Yiwen , Liu Haigang , Chen Xianfeng
Published: September 2021

Optical non-line-of-sight (NLOS) communication can exploit the indirect light path to provide free-space communications around obstacles that occlude the field of view. Here we propose and demonstrate an orbital angular momentum (OAM)-based NLOS communication scheme that can greatly improve its channel dimensionality. To verify the feasibility for extending the amount of multiplexed OAM channel dimensionality, the effects of bit accuracy versus the number of channels in measuring OAM modes are quantified. Moreover, to show the ability for broadcast NLOS tasks, we report a multi-receiver experiment where the transmitted information from scattered light can be robustly decoded by multiple neuron-network-based OAM decoders. Our results present a faithful verification of OAM-based NLOS communication for real-time applications in dynamic NLOS environments, regardless of the limit of wavelength, light intensity, or turbulence.
Generating non-uniformly correlated twisted sources
Authors: Zhu Shijun , Li Peng , Li Zhenhua , Cai Yangjian , He Weiji
Published: September 2021

The inverse method of proving the twistability of cross-spectral density (CSD) inevitably falls into spontaneous difficulties. Based on a nonnegative self-consistent design guideline for generating genuine CSDs introduced by Gori and Santarsiero, we demonstrate a feasible way for twisting partially coherent sources by sticking a Schell-model function to CSDs, which also determines the upper bound of the twisting strength. Analysis shows that the degree of coherence of a new class of twisted pseudo-Gaussian Schell-model beam is neither shift invariant nor shift-circular symmetric. In the presence of a vortex phase, the two different types of chiral phases affect each other and together control the propagation behavior. We further carry out an experiment to generate this non-uniformly correlated twisted beam using weighted superposition of mutually uncorrelated pseudo modes. The result is beneficial for devising nontrivial twisted beams and offers new opportunities.
Rejuvenated Vintage Tissue Sections Highlight Individual Antigen Fate During Processing and Long-term Storage
Authors: Mascadri Francesco , Bolognesi Maddalena M. , Pilla Daniela , Cattoretti Giorgio
Published: September 2021

Antigen-bearing proteins become progressively unavailable to immunodetection after prolonged storage of routine sections, exposed to a variety of agents, such as moisture, oxygen, and temperature. By proteomic analysis, the antigens are retained in the sections and definitely in the tissue block, pointing to fixation-independent, storage time–dependent protein modifications. Based on previous experience, we hypothesized that a combined exposure to a reducing agent and to chemicals favoring protein conformation changes would reverse the masking in aged sections. Disaccharides, lactose and sucrose, and a surfactant, added to a standard antigen retrieval buffer, reverse the negative changes in aged sections. Furthermore, they provide enhanced access to antigens in freshly cut sections, but not universally, revealing additional factors, besides heat and calcium chelation, required for antigen retrieval of individual proteins:
Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins
Authors: Khetarpal Sumeet A. , Vitali Cecilia , Levin Michael G. , Klarin Derek , Park Joseph , Pampana Akhil , Millar John S. , Kuwano Takashi , Sugasini Dhavamani , Subbaiah Papasani V. , Billheimer Jeffrey T. , Natarajan Pradeep , Rader Daniel J.
Published: September 2021

Triglyceride-rich lipoproteins (TRLs) are circulating reservoirs of fatty acids used as vital energy sources for peripheral tissues. Lipoprotein lipase (LPL) is a predominant enzyme mediating triglyceride (TG) lipolysis and TRL clearance to provide fatty acids to tissues in animals. Physiological and human genetic evidence support a primary role for LPL in hydrolyzing TRL TGs. We hypothesized that endothelial lipase (EL), another extracellular lipase that primarily hydrolyzes lipoprotein phospholipids may also contribute to TRL metabolism. To explore this, we studied the impact of genetic EL loss-of-function on TRL metabolism in humans and mice. Humans carrying a loss-of-function missense variant in LIPG, p.Asn396Ser (rs77960347), demonstrated elevated plasma TGs and elevated phospholipids in TRLs, among other lipoprotein classes. Mice with germline EL deficiency challenged with excess dietary TG through refeeding or a high-fat diet exhibited elevated TGs, delayed dietary TRL clearance, and impaired TRL TG lipolysis in vivo that was rescued by EL reconstitution in the liver. Lipidomic analyses of postprandial plasma from high-fat fed Lipg-/- mice demonstrated accumulation of phospholipids and TGs harboring long-chain polyunsaturated fatty acids (PUFAs), known substrates for EL lipolysis. In vitro and in vivo, EL and LPL together promoted greater TG lipolysis than either extracellular lipase alone. Our data positions EL as a key collaborator of LPL to mediate efficient lipolysis of TRLs in humans and mice.
Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host
Authors: Naguleswaran Arunasalam , Fernandes Paula , Bevkal Shubha , Rehmann Ruth , Nicholson Pamela , Roditi Isabel
Published: September 2021

Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them to evade the host immune response. Different isolates ofT.bruceishow heterogeneity in their repertoires of VSG genes and have single nucleotide polymorphisms and indels that can impact on genome editing.T.brucei bruceiEATRO1125 (AnTaR1 serodeme) is an isolate that is used increasingly often because it is pleomorphic in mammals and fly transmissible, two characteristics that have been lost by the most commonly used laboratory stocks. We present a genome assembly of EATRO1125, including contigs for the intermediate chromosomes and minichromosomes that serve as repositories of VSG genes. In addition,de novotranscriptome assemblies were performed using Illumina sequences from tsetse-derived trypanosomes. Reads of 150 bases enabled closely related members of multigene families to be discriminated. This revealed that the transcriptome of midgut-derived parasites is dynamic, starting with the expression of high affinity hexose transporters and glycolytic enzymes and then switching to proline uptake and catabolism. These changes resemble the transition from early to late procyclic forms in culture. Further metabolic reprogramming, including upregulation of tricarboxylic acid cycle enzymes, occurs in the proventriculus. Many transcripts upregulated in the salivary glands encode surface proteins, among them 7 metacyclic VSGs, multiple BARPs and GCS1/HAP2, a marker for gametes. A novel family of transmembrane proteins, containing polythreonine stretches that are predicted to be O-glycosylation sites, was also identified. Finally, RNA-Seq data were used to create an optimised annotation file with 5’ and 3’ untranslated regions accurately mapped for 9302 genes. We anticipate that this will be of use in identifying transcripts obtained by single cell sequencing technologies.
Assessing factors influencing communities’ acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana
Authors: Niles Reza A. , Thickstun Charles R. , Cox Horace , Dilliott Daniel , Burgert-Brucker Clara R. , Harding-Esch Emma M. , Clementson Nikita , Sampson Annastacia , Alexandre Jean Seme , Morice Trejos Ana C. , Scholte Ronaldo G. Carvalho , Krentel Alison
Published: September 2021

Background

Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability study was embedded within sentinel site mapping in four regions to assess mass drug administration (MDA) coverage and compliance, acceptability, and perceptions about treatment and disease. The results from this survey would inform the rollout of IDA in Guyana in 2019.

Methods

Data collection for the study occurred in August 2019, using a validated questionnaire administered by trained enumerators. Across all regions, a total of 1,248 participants were sampled by the Filarial Mapping team. Four-hundred and fifty-one participants aged over 18 years were randomly selected for participation in an expanded acceptability questionnaire. All data were captured in Secure Data Kit (SDK).

Results

Acceptability was measured using a mean acceptability score. Unadjusted mean scores ranged from 24.6 to 29.3, with 22.5 as the threshold of acceptability. Regional variation occurred across many indicators of interest: self-rated understanding about LF, mechanisms of LF transmission, LF drug safety and history of treatment during MDA. Region IV (Georgetown) recorded higher knowledge about LF, but lower compliance and acceptability. Number of pills was not perceived as a concern.

Conclusion

Acceptability of MDA was good across all four regions under study. Results from this study set a baseline level for key indicators and acceptability, from which the acceptability of IDA can be measured. Regional variations across indicators suggest that localized approaches should be considered for social mobilization and MDA delivery to capture these contextual differences.
The short-term effect of residential home energy retrofits on indoor air quality and microbial exposure: A case-control study
Authors: Nguyen Mytien , Holmes Eric C. , Angenent Largus T.
Published: September 2021

Weatherization of residential homes is a widespread procedure to retrofit older homes to improve the energy efficiency by reducing building leakage. Several studies have evaluated the effect of weatherization on indoor pollutants, such as formaldehyde, radon, and indoor particulates, but few studies have evaluated the effect of weatherization on indoor microbial exposure. Here, we monitored indoor pollutants and bacterial communities during reductions in building leakage for weatherized single-family residential homes in New York State and compared the data to non-weatherized homes. Nine weatherized and eleven non-weatherized single-family homes in Tompkins County, New York were sampled twice: before and after the weatherization procedures for case homes, and at least 3 months apart for control homes that were not weatherized. We found that weatherization efforts led to a significant increase in radon levels, a shift in indoor microbial community, and a warmer and less humid indoor environment. In addition, we found that changes in indoor airborne bacterial load after weatherization were more sensitive to shifts in season, whereas indoor radon levels were more sensitive to ventilation rates.
Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
Authors: Redder Esther , Kirschnick Nils , Bobe Stefanie , Hägerling René , Hansmeier Nils Rouven , Kiefer Friedemann
Published: September 2021

Lymphatic vessels are indispensable for tissue fluid homeostasis, transport of solutes and dietary lipids and immune cell trafficking. In contrast to blood vessels, which are easily visible by their erythrocyte cargo, lymphatic vessels are not readily detected in the tissue context. Their invisibility interferes with the analysis of the three-dimensional lymph vessel structure in large tissue volumes and hampers dynamic intravital studies on lymphatic function and pathofunction. An approach to overcome these limitations are mouse models, which express transgenic fluorescent proteins under the control of tissue-specific promotor elements. We introduce here the BAC-transgenic mouse reporter strain Vegfr3-tdTomato that expresses a membrane-tagged version of tdTomato under control of Flt4 regulatory elements. Vegfr3-tdTomato mice inherited the reporter in a mendelian fashion and showed selective and stable fluorescence in the lymphatic vessels of multiple organs tested, including lung, kidney, heart, diaphragm, intestine, mesentery, liver and dermis. In this model, tdTomato expression was sufficient for direct visualisation of lymphatic vessels by epifluorescence microscopy. Furthermore, lymph vessels were readily visualized using a number of microscopic modalities including confocal laser scanning, light sheet fluorescence and two-photon microscopy. Due to the early onset of VEGFR-3 expression in venous embryonic vessels and the short maturation time of tdTomato, this reporter offers an interesting alternative to Prox1-promoter driven lymphatic reporter mice for instance to study the developmental differentiation of venous to lymphatic endothelial cells.
The relation between home numeracy practices and a variety of math skills in elementary school children
Authors: Girard Cléa , Bastelica Thomas , Léone Jessica , Epinat-Duclos Justine , Longo Léa , Prado Jérôme
Published: September 2021

A growing number of studies suggest that the frequency of numeracy experiences that parents provide at home may relate to children’s mathematical development. However, the relation between home numeracy practices and children’s numerical skills is complex and might depend upon both the type and difficulty of activities, as well as the type of math skills. Studies have also argued that this relation may be driven by factors that are not systematically controlled for in the literature, including socio-economic status (SES), parental math skills and children’s IQ. Finally, as most prior studies have focused on preschoolers, it remains unclear to what extent there remains a relation between the home numeracy environment and math skills when children are in elementary school. In the present study, we tested an extensive range of math skills in 66 8-year-olds, including non-symbolic quantity processing, symbolic number understanding, transcoding, counting, and mental arithmetic. We also asked parents to complete a questionnaire about their SES, academic expectations, academic attitudes, and the numeracy practices that they provide at home. Finally, we measured their arithmetic fluency as a proxy for parental math skills. Over and above differences in socio-economic status, parental arithmetic fluency, child’s IQ, and time spent with the child, we found a positive relation between the frequency of formal numeracy practices that were at or above grade level and two separate measures of mental arithmetic. We further found that the frequency of these advanced formal numeracy practices was related to parents’ academic expectations. Therefore, our study shows that home numeracy experiences predict arithmetic skills in elementary school children, but only when those activities are formal and sufficiently challenging for children.
Creep behavior of reinforced concrete-filled steel tubular columns under axial compression
Authors: Zhang Ni , Zheng Chenyang , Sun Qingwei
Published: September 2021

The reinforced concrete-filled steel tube (RCFST) column solves several of the problems of the concrete-filled steel tube (CFST) column in practical engineering applications. Moreover, RCFST has a simple joint structure, high bearing capacity, good ductility, and superior fire resistance. From a structural safety perspective, designers prioritize the creep performance of CFST members in structural design. Therefore, the creep behavior of RCFST columns should be thoroughly investigated in practical engineering design. To study the influence of the creep behavior of RCFST columns under axial compression, this work analyzed the mechanical behavior of composite columns based on their mechanical characteristics under axial compression and established a creep formula suitable for RCFST columns under axial compression. A creep analysis program was also developed to obtain the creep strain–time curve, and its correctness was verified by existing tests. On this basis, the effects of the main design parameters, such as the stress level, steel ratio, and reinforcement ratio, on the creep behavior were determined and analyzed. The creep of the tested composite columns increased rapidly in the early stages (28 days) of load action; the growth rate was relatively low after 28 days and tended to stabilize after approximately six months. The stress level had the greatest influence on the creep of RCFST columns under axial compression, followed by the steel ratio. The influence of the reinforcement ratio on the creep behavior was less. The results of this study can provide a reference for engineering practice.
Emotion dynamics in movie dialogues
Authors: Hipson Will E. , Mohammad Saif M.
Published: September 2021

Emotion dynamics is a framework for measuring how anindividual’semotions change over time. It is a powerful tool for understanding how we behave and interact with the world. In this paper, we introduce a framework to track emotion dynamics through one’s utterances. Specifically we introduce a number ofutterance emotion dynamics (UED)metrics inspired by work in Psychology. We use this approach to trace emotional arcs of movie characters. We analyze thousands of such character arcs to test hypotheses that inform our broader understanding of stories. Notably, we show that there is a tendency for characters to use increasingly more negative words and become increasingly emotionally discordant with each other until about 90% of the narrative length. UED also has applications in behavior studies, social sciences, and public health.
Challenges in updating habitat suitability models: An example with the lesser prairie-chicken
Authors: Jarnevich Catherine S. , Belamaric Pairsa N. , Fricke Kent , Houts Mike , Rossi Liza , Beauprez Grant , Cooper Brett , Martin Russell
Published: September 2021

Habitat loss from land-use change is one of the top causes of declines in wildlife species of concern. As such, it is critical to assess and reassess habitat suitability as land cover and anthropogenic features change for both monitoring and developing current information to inform management decisions. However, there are obstacles that must be overcome to develop consistent assessments through time. A range-wide lek habitat suitability model for the lesser prairie-chicken (Tympanuchus pallidicinctus), currently under review by the U. S. Fish and Wildlife Service for potential listing under the Endangered Species Act, was published in 2016. This model was based on lek data from 2002 to 2012, land cover data ranging from 2001 to 2013, and anthropogenic features from circa 2011, and has been used to help guide lesser prairie-chicken management and anthropogenic development actions. We created a second iteration model based on new lek surveys (2015 to 2019) and updated predictors (2016 land cover and cleaned/updated anthropogenic data) to evaluate changes in lek suitability and to quantify current range-wide habitat suitability. Only three of 11 predictor variables were directly comparable between the iterations, making it difficult to directly assess what predicted changes resulted from changes in model inputs versus actual landscape change. The second iteration model showed a similar positive relationship with land cover and negative relationship with anthropogenic features to the first iteration, but exhibited more variation among candidate models. Range-wide, more suitable habitat was predicted in the second iteration. The Shinnery Oak Ecoregion, however, exhibited a loss in predicted suitable habitat that could be due to predictor source changes. Iterated models such as this are important to ensure current information is being used in conservation and development decisions.
Systematic review and standardised assessment of Chinese cross-cultural adapted hip Patient Reported Outcome Measures (PROMs)
Authors: Ngwayi James Reeves Mbori , Tan Jie , Liang Ning , Sita Emmanuel Gildas Eric , Obie Kenedy Uzoma , Porter Daniel Edward
Published: September 2021

Purpose

To perform a systemic literature search to identify Chinese cross culturally adapted and new designed Patient Reported Outcome Measures (PROMs) used for hip assessment, then a standardized evaluation of available instruments in order to provide evidence of high-quality PROMs for clinical use and adoption in future hip registries.

Methods

A Systematic Review of the following databases: PUBMED, CINAHL, EMBASE, CNKI was performed to identify relevant PROMs. Instruments underwent standardized assessment and scoring using the EMPRO tool by two independent reviewers. Inter-rater reliability was assessed using intra-class correlation coefficients (ICC).

Results

2188 articles were retrieved, with seven articles fitting the inclusion criteria consisting of six hip PROMs. Five PROMs were cross culturally adapted and one was originally designed in Mandarin Chinese. Total scores (/100) after EMPRO evaluation: Osteoarthritis of Knee and Hip Quality of Life (OAKHQOL): 55; Copenhagen Hip and Groin Outcome Score (HAGOS): 52; International Hip Outcome Tool (SC-iHOT-33): 45; Hip Disability and Osteoarthritis Outcome Score (HOOS): 37; Questionnaire on the Perceptions and Functions of Patients about Total Hip Arthroplasty (QPFPTHA): 36; Oxford Hip Score (OHS): 35. ICC values were 0.73 for the SC-iHOT-33 and ranged between 0.83–0.93 for the other PROMs indicating good to excellent inter-rater agreement.

Conclusion

Among the commonly used hip-specific PROMs found in arthroplasty registries, none of the Chinese adapted versions evaluated by EMPRO is currently rated acceptable for clinical use. Only OAKHQOL and HAGOS reached acceptability threshold. Further research on the attributes of cross-cultural adaptation, interpretability and burden assessment would be helpful.
Identification of high-risk COVID-19 patients using machine learning
Authors: Quiroz-Juárez Mario A. , Torres-Gómez Armando , Hoyo-Ulloa Irma , León-Montiel Roberto de J. , U’Ren Alfred B.
Published: September 2021

The current COVID-19 public health crisis, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has produced a devastating toll both in terms of human life loss and economic disruption. In this paper we present a machine-learning algorithm capable of identifying whether a given patient (actually infected or suspected to be infected) is more likely to survive than to die, or vice-versa. We train this algorithm with historical data, including medical history, demographic data, as well as COVID-19-related information. This is extracted from a database of confirmed and suspected COVID-19 infections in Mexico, constituting the official COVID-19 data compiled and made publicly available by the Mexican Federal Government. We demonstrate that the proposed method can detect high-risk patients with high accuracy, in each of four identified clinical stages, thus improving hospital capacity planning and timely treatment. Furthermore, we show that our method can be extended to provide optimal estimators for hypothesis-testing techniques commonly-used in biological and medical statistics. We believe that our work could be of use in the context of the current pandemic in assisting medical professionals with real-time assessments so as to determine health care priorities.
Size effect of parallel-joint spacing on uniaxial compressive strength of rock
Authors: Hu Gaojian , Ma Gang
Published: September 2021

The existence of parallel joints has an impact on the size effect of the uniaxial compressive strength of rock, but the relationship is yet to be obtained. In this paper, the influence of parallel-joint spacing on the size effect and characteristic size of rock uniaxial compressive strength is studied by establishing five types of parallel-joint-spacing simulation schemes. The influence of parallel-joint spacing on the size effect of rock uniaxial compressive strength is explored by analyzing the stress–strain curves of rocks with different parallel-joint spacings and rock sizes. The relationship between the uniaxial compressive strength and the size of the rock with parallel joints and its special mathematical model are obtained, and the particular form of the compressive-strength characteristic size and parallel-joint spacing is obtained.
Quantitative use-wear analysis of stone tools: Measuring how the intensity of use affects the identification of the worked material
Authors: Ibáñez Juan José , Mazzucco Niccolò
Published: September 2021

The identification of the use of stone tools through use-wear analysis was one the major methodological advances in Prehistoric Archaeology during the second half of the 20th century. Studies of use-wear analysis have decisively contributed to a better understanding of the cognitive capacities and the socio-economic organization of Prehistoric societies. Among use-wear traces, microwear polish is the most relevant evidence, as it allows the identification of the worked materials (i.e. wood, antler, hide, bone, stone…). This identification is currently carried out through the qualitative and visual comparison of experimental and archaeological tools. During the last decade, confocal microscopy is allowing the quantitative identification of the worked material through the texture analysis of microwear polish. Previous tests have accounted for the variability of use-wear traces as caused by different types of worked material. However, how the intensity of use, which is widely recognized as an important factor conditioning microwear polish characteristics, affects our capacity to identify the worked materials is poorly understood. This research addresses the dynamic nature of microwear polish through confocal microscopy and texture analysis. This research shows that use-wear polishing is a dynamic process and surface texture evolves continuously during the working time. The evolution fits a logarithmic function, so most texture modification takes place during the first phases of work. The way in which polish texture evolves through time differs from one contact material to the other. We demonstrate that, despite the dynamic nature of use-wear polish, different worked materials can be discriminated. However, some overlapping between used and unused surfaces and between worked materials occurs in the first stages of use. Moreover, polishes of similar characteristics (i.e. bone and antler) can show similar texture at advanced stages of use. These problems in identification can be in good measure overcome by creating dynamic models of polish texture in which not only the worked material but also the time of use is considered.
Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart
Authors: Tang Yanbo , Kline Kevin T. , Zhong Xiaoying S. , Xiao Ying , Lian Haifeng , Peng Jun , Liu Xiaowei , Powell Don W. , Tang Guodu , Li Qingjie
Published: September 2021

Ulcerative colitis and Crohn’s disease are classified as chronic inflammatory bowel diseases (IBD) with known extraintestinal manifestations. The interplay between heart and gut in IBD has previously been noted, but the mechanisms remain elusive. Our objective was to identify microRNAs mediating molecular remodeling and resulting cardiac impairment in a rat model of colitis. To induce chronic colitis, dextran sodium sulfate (DSS) was given to adult rats for 5 days followed by 9 days with normal drinking water for 4 cycles over 8 weeks. Echocardiography was performed to evaluate heart function. DSS-induced colitis led to a significant decrease in ejection fraction, increased left ventricular mass and size, and elevated B-type natriuretic protein. MicroRNA profiling showed a total of 56 miRNAs significantly increased in the heart by colitis, 8 of which are predicted to target brain-derived neurotrophic factor (BDNF). RT-qPCR validated the increases of miR-1b, Let-7d, and miR-155. Transient transfection revealed that miR-155 significantly suppresses BDNF in H9c2 cells. Importantly, DSS colitis markedly decreased BDNF in both myocardium and serum. Levels of various proteins critical to cardiac homeostasis were also altered. Functional studies showed that BDNF increases cell viability and mitigates H2O2-induced oxidative damage in H9c2 cells, demonstrating its protective role in the adult heart. Mechanistically, cellular experiments identified IL-1β as the inflammatory mediator upregulating cardiac miR-155; this effect was confirmed in adult rats. Furthermore, IL-1β neutralizing antibody ameliorated the DSS-induced increase in miR-155 and concurrent decrease in BDNF in the adult heart, showing therapeutic potential. Our findings indicate that chronic colitis impairs heart function through an IL-1β→miR-155→BDNF signaling axis.
The contribution of metamemory beliefs to the font size effect on judgments of learning: Is word frequency a moderating factor?
Authors: Fan Tian , Zheng Jun , Hu Xiao , Su Ningxin , Yin Yue , Yang Chunliang , Luo Liang
Published: September 2021

Previous studies found that metamemory beliefs dominate the font size effect on judgments of learning (JOLs). However, few studies have investigated whether beliefs about font size contribute to the font size effect in circumstances of multiple cues. The current study aims to fill this gap. Experiment 1 adopted a 2 (font size: 70 pt vs. 9 pt) * 2 (word frequency (WF): high vs. low) within-subjects design. The results showed that beliefs about font size did not mediate the font size effect on JOLs when multiple cues (font size and WF) were simultaneously provided. Experiment 2 further explored whether WF moderates the contribution of beliefs about font size to the font size effect, in which a 2 (font size: 70 pt vs. 9 pt, as a within-subjects factor) * 2 (WF: high vs. low, as a between-subjects factor) mixed design was used. The results showed that the contribution of beliefs about font size to the font size effect was present in a pure list of low-frequency words, but absent in a pure list of high-frequency words. Lastly, a meta-analysis showed evidence supporting the proposal that the contribution of beliefs about font size to the font size effect on JOLs is moderated by WF. Even though numerous studies suggested beliefs about font size play a dominant role in the font size effect on JOLs, the current study provides new evidence suggesting that such contribution is conditional. Theoretical implications are discussed.
Empathy and its associations with age and sociodemographic characteristics in a large UK population sample
Authors: Sommerlad Andrew , Huntley Jonathan , Livingston Gill , Rankin Katherine P. , Fancourt Daisy
Published: September 2021

Objectives

Empathy is fundamental to social cognition, driving prosocial behaviour and mental health but associations with aging and other socio-demographic characteristics are unclear. We therefore aimed to characterise associations of these characteristics with two main self-reported components of empathy, namely empathic-concern (feeling compassion) and perspective-taking (understanding others’ perspective).

Methods

We asked participants in an internet-based survey of UK-dwelling adults aged ≥18 years to complete the Interpersonal Reactivity Index subscales measuring empathic concern and perspective taking, and sociodemographic and personality questionnaires. We weighted the sample to be UK population representative and employed multivariable weighted linear regression models.

Results

In 30,033 respondents, mean empathic concern score was 3.86 (95% confidence interval 3.85, 3.88) and perspective taking was 3.57 (3.56. 3.59); the correlation between these sub-scores was 0.45 (p < 0.001). Empathic concern and perspective taking followed an inverse-u shape trajectory in women with peak between 40 and 50 years whereas in men, perspective taking declines with age but empathic concern increases.

In fully adjusted models, greater empathic concern was associated with female gender, non-white ethnicity, having more education, working in health, social-care, or childcare professions, and having higher neuroticism, extroversion, openness to experience and agreeableness traits. Perspective taking was associated with younger age, female gender, more education, employment in health or social-care, neuroticism, openness, and agreeableness.

Conclusions

Empathic compassion and understanding are distinct dimensions of empathy with differential demographic associations. Perspective taking may decline due to cognitive inflexibility with older age whereas empathic concern increases in older men suggesting it is socially-driven.