bluuebunny/crossref_metadata_2025 huggingface dataset:
“It Might Have a Little to Do with Wish Fulfillment”: The Life-Giving Force of Queer Performance in TTRPG Spaces
Authors: Sottile Emry
Published: June 2024

In Cruel Optimism, Lauren Berlant asserts that “fantasy [can serve] as a life-sustaining defense against the attritions of ordinary violent history,” which is a statement that holds true for many queer role-players in TTRPG spaces (Berlant 2012, 45). Around the table, these worlds enable players to discover and render their identities legible in social utopian spaces and rehearse their performance for life outside of them. Through engaging with scholarship, autoethnographic writing, and cultural production surrounding TTRPGs, queer identity, avatars, and gender performance, this project asserts that TTRPGs function as safe spaces for becoming, due in part to the ability to create an avatar, or “flexible representational stand-in” for the self, that is queer and embodied through role-play (McMillan, 2015 13). This is achieved through tracking the author’s experience of discovering and forming their queer and trans identity through role-playing various characters and disciplining their function through related interdisciplinary theory across queer, feminist, and role-playing studies. Additionally, through utilizing additional ethnographic accounts and analyzing TTRPG-based media in theatre and actual play spaces, this project further establishes how the emancipatory potential in escapist TTRPG fantasy spaces can ultimately alter queer role-players’ engagement with material reality in a world adversarial to their existence and visibility, especially in light of the past few years.
Kolaborasi dalam Aksi untuk Peta Jalan Energi yang Inklusif
Authors:   Purnomo Yusgiantoro Center, Center Purnomo
Published: June 2024

Transformasi untuk mencapai tujuan transisi energi yang inklusif tidak terlepas dari kolaborasi, sinergi, dan kerjasama pemangku kepentingan. Untuk itu, kami telah merangkum rekomendasi untuk mendukung pembentukan kerangka kerja untuk transisi energi Indonesia yang inklusif, berdasarkan pada perspektif pentahelix—sinergi antara pemerintah, sektor swasta, akademisi, lembaga swadaya masyarakat (LSM), dan media. Melalui pendekatan inklusif ini, setiap sektor dan pemangku kepentingan terlibat aktif dalam transisi energi Indonesia, serta mendorong upaya komprehensif dan kolaboratif menuju masa depan energi yang berkelanjutan.
EFECTIVIDAD DEL BLOQUEO PEC II COMPARADO CON ANALGESIA ENDOVENOSA EN MONODOSIS EN PACIENTES POST MASTECTOMIA POR CÁNCER DE MAMA
Authors: Santillan Rojas Claudia Isabel , Caballero Alvarado José Antonio
Published: June 2024

Objective: To determine whether in post-mastectomy breast cancer patients, PEC II block plus single-dose intravenous analgesia is more effective than single-dose intravenous analgesia in treating postoperative pain.
Methods: An cohort study was conducted between June and September 2022 with 60 breast cancer patients who underwent unilateral mastectomy. Two groups of 30 patients each were formed: one received PECS II Block plus EV Analgesia and the other only EV Analgesia. Inclusion criteria covered patients with ASA physical status 1 or 2, aged 18 to 70 years, and excluded those with drug allergies, serious diseases and those who refused to participate.
Results: Patients who received EV Analgesia alone reported higher values of pain measured by the Visual Analog Scale compared to those who received PECS II Block plus EV Analgesia, with significant differences (p = 0.001). In terms of adverse effects, all patients in the PECS II Block and EV Analgesia group experienced no negative effects, while in the EV Analgesia only group, 100% required rescue analgesia, and there were reports of vomiting, headache and nausea.
Conclusion: PECS II Block in combination with EV Analgesia proved to be more effective in postoperative pain control in patients undergoing unilateral mastectomy for breast cancer, significantly reducing the need for rescue analgesia and the occurrence of adverse effects compared to EV Analgesia alone.
Características y complicaciones de las gestantes con edad materna avanzada en un Instituto Materno Oeruano, 2022
Authors: Urbina Castillo Nelth Samantha , Luna Figueroa Antonio
Published: June 2024

Objective. To characterize pregnant women of advanced maternal age and, in an exploratory manner, assess the factors associated with the presentation of complications in this population, at a Peruvian maternal institute in 2022. Materials and Methods.  onducted at the National Maternal Perinatal Institute during the year 2022. A total of 191 medical records that met the inclusion and exclusion criteria were reviewed. Analyses were subsequently performed using IBM SPSS software, version 25.0. Descriptive and bivariate statistical analyses were carried out using the Chi-square test. Crude prevalence ratios with their 95% confidence intervals were also calculated using Poisson regression with robust variances. Results. It was found that the prevalence of cesarean sections was 87% among elderly pregnant women, with the main indications for cesarean being severe preeclampsia at 25.9%, the most frequent pathology being intrauterine growth restriction (IUGR) at 24.7%, and fetal distress syndrome (FDS) at 23.5% in the patients. The bivariate analysis showed a statistically significant association between severe preeclampsia and gestational age (RRa: 0.881; 95% CI: 0.837 - 0.926). Conclusion. 20% of the pregnant women treated at a Peruvian institute had advanced maternal age.
Legalitas usaha kelompok wanita tani
Authors: Yuzianah Dita , Maryam Isnaeni , Zulfanita  , Harianto Eko
Published: June 2024

Pemanfaatan hasil kebun untuk berwirausaha adalah salah satu upaya untuk meningkatkan ekonomi. Disatu sisi mereka ingin mengembangkan usahanya di sisi lain mereka terkendala dari segi legalitas usaha, karena syarat usaha bisa masuk ke minimarket dan supermarket adalah adanya legalitas usaha, sedangkan warga desa semangung masih minim informasi tentang legalitas usaha. Sehingga sementara ini produk dari desa semangun hanya dipasarkan di daerah sekitar karena sebagian besar produk belum memiliki legalitas usaha seperti pirt dan halal. Karena itu tujuan dari diadakanya pengabdian ini diantaranya: mengenalkan berbagai macam legalitas usaha dan mendampingi pelaku usaha di desa semangung untuk mengurus legalitas usaha. Metode pengabdian yaitu mengunakan metode PAR (Participatory Action Research). Dengan tahap pelaksanaan: tahap to know yaitu mengetahui kondisi riel komunitas, tahap to Understand (Memahami Problem Komunitas), tahap to Plann (Merencanakan Pemecahan Masalah Komunitas), tahap to Act (Melakukan Program Aksi Pemecahan Masalah), tahap to Change (Membangun Kesadaran untuk perubahan dan keberlanjutan). Kegiatan ini memberikan dampak yang signifikan yaitu dari 90% pelaku usaha yang belum memiliki legalitas usaha mendapatkan legalitas usaha dari NIB, PIRT dan juga legalitas halal. Tentunya setelah mendapatkan legalitas usaha produk masyarakat desa Semangung semakin biasa dipasarkan secara luas seperti minimarket dan juga supermarket atau di pusat oleh-oleh dan memiliki kekuatan hukum. Kedepanya kami akan mendampingi dari segi pemasaran dan juga memaksimalkan produk pertanian menjadi suatu produk.
Beyond the classroom: Fostering English communication skills in vocational education through podcasting and radio broadcasting
Authors: Hamid Syifa Fadhilah , Forsia Lastry , Isnaniah Isnaniah
Published: June 2024

Addressing the challenge of developing effective English communication skills in vocational education, this study explores the integration of podcasting and radio broadcasting as an alternative to traditional classrooms. The goal is to provide vocational students with a more immersive and practical learning experience in line with communicative language teaching principles. Putra Rifara Vocational School initiated a Radio Podcast program, emphasizing technological proficiency. A seminar, "Hosting Podcast in English," was conducted to train students in podcasting and radio broadcasting. Practical exercises were included to enhance language skills, including articulation, opinion expression, and real-time dialogues. A needs analysis revealed students' interest in podcasts as learning material, with challenges related to internet limitations. The initiative positively impacted students' attitudes, behaviors, linguistic proficiency, and soft skills development. Ongoing training and mentorship are recommended to empower students in confidently hosting English podcasts. This initiative demonstrates the potential of podcasting and radio broadcasting to enrich English language learning in vocational education, contributing to linguistic proficiency and soft skills development within the educational environment. Considerations for improving internet accessibility and guiding podcast selection are recommended for future implementations.
Kultur jaringan tumbuhan dasar sebagai upaya peningkatan pengetahuan dan keterampilan siswa
Authors: Restiani Ratih , Kaban Sarah Mega Pratenna , Sekar Astrid Ayu , Matheos Josiah Harold , Galgani Gemma
Published: June 2024

Perkembangan IPTEK saat ini berkontribusi dalam meningkatnya implementasi bioteknologi dalam kehidupan manusia. Kultur jaringan tumbuhan merupakan salah satu aplikasi bioteknologi di bidang pertanian. Pengenalan kultur jaringan tumbuhan sejak dini bagi siswa SMA menjadi salah satu upaya mempersiapkan SDM yang terampil. Namun demikian, siswa SMA masih mengalami kesulitan dalam proses pembelajaran bioteknologi terutama pada topik ini. Pembelajaran yang berfokus pada teori dan tidak dilengkapi dengan kegiatan praktikum merupakan penyebab siswa sulit memahami pelajaran tersebut. Kendala ini terutama dialami oleh siswa kelas XII SMA BOPKRI I Yogyakarta. Oleh karena itu, kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan dasar siswa pada materi kultur jaringan tumbuhan. Metode kegiatan pengabdian adalah participatory Action Research (PAR) yang diberikan dalam bentuk pelatihan. Pelaksanaan pelatihan dibagi menjadi dua sesi yaitu pemaparan materi pengantar, demonstrasi praktikum dan kegiatan praktikum. Acara praktikum meliputi pembuatan media kultur dan sterilisasi serta inokulasi eksplan. Berdasarkan hasil evaluasi, kegiatan pengabdian ini telah berhasil sebesar 100% dalam meningkatkan pengetahuan berdasarkan hasil tanya jawab selama pelatihan serta keterampilan dalam melaksanakan tahapan kultur jaringan tumbuhan. Kegiatan pengabdian kepada masyarakat ini lebih lanjut dapat diintegrasikan dengan kegiatan pembelajaran biologi di kelas sehingga proses pelatihan dan pendampingan mengenai kultur jaringan tumbuhan dapat berlangsung lebih intensif. Selain itu, project kelompok yang diberikan selama kegiatan pengabdian dapat membantu siswa dalam mencapai tujuan pembelajaran bioteknologi di kelas.
Design of Metal Sulfide Electrode for Hydrogen Production by Electrolysis
Authors: Yang He , Kudashev S.
Published: June 2024

Hydrogen evolution reaction (HER) is the cathodic hydrogen evolution reaction in electrolytic cell, but the hydrogen evolution catalytic properties of electrode materials best remains is the precious metal catalyst, therefore, in order to study the catalytic performance is good, and cheap hydrogen evolution electrode materials has become the research hot spot, metal sulfide can be mixed and with good electrical conductivity is it can be used as a necessary condition for hydrogen evolution electrode, The core theory of this paper is the first principle. By taking metal sulfide as the matrix and doping it with 10 metal group elements, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu and Zn, we obtained the configuration of 20 metal sulfide by doping it at two different sites of S atom, and inlaid H atom into metal atom. Then, through the use of software to study its catalytic performance, through the free energy analysis, rate analysis, bond length analysis, density of states analysis, charge analysis method, compared and found the most suitable doping metal element V, thus also determined that metal sulfide can be used as hydrogen evolution electrode through metal doping.
The Energy Circuit of the Exhaust Gas Heat Recovery Circuit of a 25 kW Diesel Generator
Authors: Zhou M. , Kuznetsov D.
Published: June 2024

The purpose of the work is to describe the installation using differential equations and obtain approximate values before the experiment. In this paper, a constructive scheme of the experimental device is proposed, and the principle of its operation is described in detail. The power circuit of the device has been drawn up. Complex impedance, frequency function, amplitude-frequency characteristic and phase-frequency characteristic are obtained by mathematical transformation of the power circuit. The frequency response of the circuit is constructed. As a result of the calculations, we will obtain the amplitude frequency response and the phase frequency response. Using the found values of the characteristics, we will build graphs and draw conclusions about how the characteristics depend on the change in parameters and why the graph lines of the graphs are exactly the way they are.
Analysis and Optimization of the Flow Path within the Protonic Ceramic Fuel Cell Stack
Authors: Chen Rentian , Efimov A.
Published: June 2024

With the development of human society, the demand for energy is increasing, and energy, an essential global necessity, is decreasing significantly and is in danger of being depleted. Fuel cell is the fourth power generation facility after hydroelectric, thermal and nuclear power. Fuel cell flow channel is an important part of fuel cell, which has the functions of transferring reaction gas, discharging products and excess unreacted gas, and balancing fuel cell temperature. This thesis focuses on the model design and optimization of a 10-layer flat-plate proton ceramic fuel cell (PCFC) reactor. First, we design a 10-layer flat-plate PCFC reactor model structure, then we simulate the reactor using Fluent, analyze the multi-field coupling operating characteristics inside the target reactor, optimize the reactor based on the results, and finally, we analyze and discuss the optimization results.
Energy Circuit of a Thermal Circuit with a Direct-acting Regulator with a Capacity of 1 MW in Pulsating Mode
Authors: Han Wang , Maltsev S.
Published: June 2024

The purpose of the work is to describe the installation using differential equations and obtain approximate values before the experiment. In this paper, a constructive scheme of the experimental device is proposed, and the principle of its operation is described in detail. The power circuit of the device has been drawn up. Complex impedance, frequency function, amplitude-frequency characteristic and phase-frequency characteristic are obtained by mathematical transformation of the power circuit. The frequency response of the circuit is constructed. As a result of the calculations, we will obtain the amplitude frequency response and the phase frequency response. Using the found values of the characteristics, we will build graphs and draw conclusions about how the characteristics depend on the change in parameters and why the graph lines of the graphs are exactly the way they are.
The Model of Ethnopedagogical Training of Students of a Pedagogical University
Authors: Sarkanbaeva G. , Aitzhanova S.
Published: June 2024

The ethnopedagogic orientation of education and upbringing is one of the main ones in the modern educational policy of the Republic of Kazakhstan. This is stated in the platform of the state policy of the Republic of Kazakhstan on socio-cultural development, that special attention is paid to the specifics of the culture of all peoples living in the republic, and that any culture is a unique, incomparable asset, and that a certain population fully presents itself to the world. Therefore, today the university offers conditionally three stages in order to reorient the ethnopedagogic system of education and upbringing. This program contains the content of ethnopedagogic education — a scientifically based system of students’ knowledge, attitude of responsibility to national history, language, culture, traditions, on the basis of which a model of the research problem is proposed through a systematic analysis of structural and substantive changes in ethnopedagogic education and upbringing of students. On the basis of the proposed model, the works of research scientists in the organization of the educational process were analyzed, the pedagogical possibilities of the ethnopedagogic heritage were taken into account, along with theoretical and methodological justification, a meaningful analysis of methodological manuals and educational programs operating in the pedagogical process was carried out in the development of scientific and methodological recommendations.
Game Start in Forming Students’ Russian Speech Communication Skills
Authors: Khasanov N. , Kalenderova N. , Baktybek k.A.
Published: June 2024

Games are an effective and entertaining way to develop students’ Russian speech communication skills. They not only improve your vocabulary, grammar and pronunciation, but also develop communication skills, the ability to express your thoughts and ideas, as well as interaction with others. According to the authors, the use of games in the educational process helps make learning more fun and interesting, and also contributes to a deeper understanding of the material. The authors came to the conclusion that the use of games in developing students’ Russian speech communication skills is an effective method that helps not only improve language skills, but also the development of communication skills and students’ enthusiasm for the educational process.
Speech Development in Russian Language Lessons with Kyrgyz Language of Instruction
Authors: Khasanov N. , Mursalieva K.
Published: June 2024

The article examines the issue of developing students’ speech during Russian language lessons in Kyrgyz schools. It analyzes the current state of Russian language teaching, evaluates the methods and approaches used by teachers, and offers recommendations for improving the process of student speech development. The authors pay special attention to the use of interactive techniques, games and exercises in the classroom, as well as the introduction of innovative approaches to speech teaching, which can contribute to more effective language acquisition in students.
Formation of the Kyrgyz State as a Political System of Kyrgyzstan
Authors: Bekmurzaeva G.
Published: June 2024

On October 14, 1924, the II session of the All-Russian Central Executive Committee of the Soviets, having considered the resolution of the Turk Central Executive Committee on national-state delimitation, made and approved the following changes: it was decided to transform the Tajik Autonomous Region into the Tajik Autonomous Soviet Socialist Republic within the Uzbek SSR; The Kara-Kalpak Autonomous Region was introduced into the Kyrgyz (Kazakh) Autonomous Soviet Socialist Republic, and the Kara-Kyrgyz (Kyrgyz) Autonomous Region directly into the RSFSR.Thus, the national statehood of the Kyrgyz people dates back to October 14, 1924.
The Effect of Hypokinesia on the Dynamics of the Formed Elements of Blood during the Embryonic Period of Prenatal Development in Pregnant Rabbits
Authors: Hamidova J. , Kazimov A. , Aghayeva E.
Published: June 2024

The erythroformula and leucoformula indicators changed in the rabbits that experienced hypokinesia during the embryonic stage of pregnancy. Compared to the rabbits that spent the pregnancy period under normal conditions, changes in concentrations of leukoformula indicators such as leukocytes, lymphocytes, monocytes, and granulocytes were detected in rabbits exposed to hypokinesia. While significant changes in erythroformula indicators: erythrocytes, average corpuscular volume of erythrocytes and hemoglobin capacity, erythrocyte sedimentation rate did not occur. The results of our studies have shown that prenatal hypokinesia causes noticeable changes in the blood coagulation system. On the other hand, changes in the coagulation system under the influence of prenatal hypokinesia were found to occur in the first periods of postnatal ontogenesis, had a continuous nature, and were maintained until the full maturity of postnatal development. Due to the effect of the hypokinesia factor, the changes in the mentioned indicators lead to the emergence of severe pathological diseases in most cases.
LEXICAL AND POST-LEXICAL PROSODIC DOCUMENTATION OF EMBALOH LANGUAGE
Authors: IRAWAN Yusup , SETIAWAN Foni Agus , ASFAR Dedy Ari , Irmayani  , Herpanus  , PRAMULYA Muhammad
Published: June 2024

This research investigated the prosody of the Embaloh language, which has yet to be widely explored, to document and preserve the language. The method used is data collection of spontaneous and non-spontaneous speeches from 12 native speakers. Prosodic analysis was then carried out based on visualising and observing speech sound waves using the autosegmental-metrical theory (AM) framework. The results show that prominence tends to be on the right edge at both lexical and post-lexical prosodic levels. The findings show that the Embaloh language is outside the mainstream of Austronesian languages, which places word stress at the penultimate syllable. At the post-lexical level in interrogative intonation, phrases with a question word are marked by the pitch accent located at the target question word in the nuclear contour of the phrase. The pitch accent follows the position of the question word in the intonation phrase, forward or backward, with one of the following tones: H* (high), LH* (low-high), or LHL* (low-high-low). The intonation of the question is indicated by the H(high) tone at the end of the phrase. The H (high) tone also acts as a boundary tone represented by H*% (high).
THE ROLE OF EXTRAMURAL ENGLISH EXPOSURE AS REVEALED IN THE LANGUAGE ACCURACY OF SECONDARY SCHOOL EFL WRITERS
Authors: OEI Bing Bing , MUSTOFA Ali , ANAM Syafi'ul
Published: June 2024

Studying in an international school setting offers an excellent opportunity for students to acquire the target language, English, through abundant language exposure. As observed during classroom observations, several students outperformed their peers in targeted language production despite the same school language exposure. Extramural English is assumed to play a substantial influence. This case study explored the Extramural English exposure of 15 ninth-grade students, the duration of such exposure, and the language accuracy of their academic writing captured after receiving it. A qualitative design was utilised to examine the data acquired from students’ linguistics background survey, daily online logs, interview transcription, and their writing products. The findings reveal that parents are the central agency facilitating language learning. During the eight-week research period, 80% of the students received interactive Extramural English, while 100% were exposed to non-interactive Extramural English. The frequency of receiving Extramural English exposure is more significant than the onset of exposure. A minimal linguistic error was recognised for 29% of average conciseness and 23% of inappropriate punctuation, while other errors were between 1% and 5%. This research highlights the importance of Extramural English exposure to written language accuracy among secondary EFL students.
Pengembangan Media Pembelajaran HAFWA Berbasis HTML5 Berpendekatan Pendidikan Matematika Realistik Pada Materi Bentuk Aljabar
Authors: Marsa Istiana Salsabila  , Nanang Nabhar Fakhri Auliya
Published: June 2024

Permasalahan yang dialami siswa dalam menguasai materi bentuk aljabar pada pembelajaran matematika adalah kurangnya keaktifan siswa saat belajar matematika karena pembelajaran hanya terpusat pada guru. Inovasi media pembelajaran berbasis teknologi menjadi landasan penelitian sebagai solusi yang dapat membantu siswa dalam penguasan materi. Penelitian ini merupakan penelitian pengembangan (Research and Development) dengan menggunakan instrument pengumpulan data yang terdiri dari lembar penilaian ahli yang berupa angket uji kelayakan ahli, dan lembar respon pengguna. Tujuan penelitian ini adalah untuk mendeskripsikan setiap tahapan yang dilakukan dalam pengembangan, serta tingkat kelayakan media pembelajaran HAFWA. Hasil dari penelitian ini didapatkan bahwa tingkat kelayakan dari media pembelajaran HAFWA ini diperoleh skor rata-rata 80,5 dari ahli materi, dan dari ahli media diperoleh skor rata-rata 90,5 dengan kriteria “sangat layak”. Kemudian uji coba produk dilakukan pada subjek 34 siswa kelas VII, yaitu uji coba produk skala kecil diperoleh skor rata-rata 100 dan pada uji coba skala besar diperoleh skor rata-rata 90,83 yang keduanya memperoleh kategori “sangat layak”. Dengan demikian, dapat disimpulkan bahwa media pembelajaran HAFWA berbasis HTML5 berpendekatan matematika realistik layak digunakan sebagai alternatif media pembelajaran dalam proses pembelajaran matematika.
PERBEDAAN AKIBAT HUKUM TALAK TIGA YANG JATUH DI LUAR DAN DI DEPAN SIDANG PENGADILAN PERSPEKTIF FIQIH EMPAT MAZHAB
Authors: Malinda Rosi , Zahro Fatimatuz , Nafik Moh
Published: June 2024

Perceraian dapat terjadi salah satunya karena talak yang menjadi sebab putusnya perkawinan. Talak berasal dari kata ‘ithlaq’ yang dalam bahasa Arab artinya melepaskan atau membebaskan. Jika dihubungkan dengan perkawinan, talak atau thalaq artinya melepaskan ikatan perkawinan secara dan mengakhiri hubungan suami istri. Talak dapat dirujuk kembali selama istri masih dalam masa iddah adalah pada talak kesatu dan kedua. Namun beberapa perkara perceraian khususnya cerai talak di Pengadilan yang mana suami sudah menjatuhkan talak lebih dari tiga kali tetapi Majelis Hakim dalam amar putusannya hanya memberikan izin menjatuhkan talak raj’i kepada suami. Hal ini menimbulkan akibat hukum yang berbeda antara talak diluar dan didepan sidang Pengadilan fiqih empat mazhab. Penelitian ini bertujuan untuk mengetahui perbedaan akibat hukum tersebut.
jenis penelitian dalam judul ini adalah Penelitian yuridis normatif yang menggunakan pendekatan konseptual. Dalam penelitian ini, teknik pengumpulan data yang dilakukan dengan cara mengumpulkan bahan hukum primer dan bahan hukum sekunder yang memiliki kaitan dengan pokok masalah dalam penelitian ini. Kemudian, teknik analisis data yuridis normatif yang disajikan dengan deskriptif dengan menggambarkan akibat hukum talak tiga diluar dan didepan persidangan.
Hasil penelitian menunjukan bahwa talak tiga yang jatuh di luar sidang Pengadilan diakui sah secara agama saja sehingga perkawinan itu terputus saat talak itu dijatuhkan yang menyebabkan tidak ada lagi kehalalan istri untuk suaminya. Sedangkan talak tiga di depan persidangan dianggap talak satu jika perkara tersebut adalah perceraian pertama yang dipersidangkan maka akibat hukum yang muncul adalah berlaku hukum talak satu.
Sedangkan menurut empat Imam Madzhab jatuhnya talaq adalah dengan apa yang diniatkan suami tidak ada keharusan menjatuhkan talaq di depan pengadilan karena talaq adalah sepenuhnya milik suami.Tujuan dijatuhkannya talaq didepan persidangan adalah untuk melindungi hak istri dan anak setelah perceraian.
Sosialisasi Kesehatan Reproduksi dan Gizi pada Remaja
Authors: Pujilestari Intan , Dimas Monica Rizqy , Suharto Suharto , Hada Encep , Nulhakim Lukman
Published: June 2024

Kesehatan organ reproduksi bermula dari menjaga kebersihan diri, termasuk kebersihan vagina yang bertujuan agar vagina tetap bersih, normal, sehat dan terhindar dari kemungkinan muncul adanya penyakit. Kesehatan reproduksi merupakan hal penting bagi setiap orang, pria ataupun wanita, namun wanita mempunyai organ yang lebih sensitif terhadap suatu penyakit, bahkan keadaan penyakit lebih banyak dihubungkan dengan fungsi dan kemampuan reproduksinya. Remaja merupakan kelompok yang rentan mengalami masalah gizi, baik kelebihan maupun kekurangan gizi. Masalah gizi pada remaja akan berdampak pada status kesehatan sehingga berisiko mengalami penyakit. Usia remaja membutuhkan lebih banyak energi dan zat gizi karena periode kehidupan remaja diperlukan untuk mempersiapkan diri memasuki usia reproduktif. Metode yang digunakan melalui tatap muka dengan ceramah tanya jawab. Semua kegiatan berjalan baik dan lancar sesuai dengan jadwal acara yang sudah direncanakan.
Overexpression of LAG-3: a potential indicator of low immune function in tuberculosis
Authors: Pan Yun , Yao Zengxi , Huang Lifen , Xu Meina , Chen Ruichang , Li Dengsheng , Wang Xinyuan , Wu Jianchao , Li Minran , Liang Xujing , Tan Jiaxiong
Published: June 2024

Background

Tuberculosis (TB) persists as a global health challenge, with its treatment hampered by the side effects of long-term combination drug therapies and the growing issue of drug resistance. Therefore, the development of novel therapeutic strategies is critical. This study focuses on the role of immune checkpoint molecules (ICs) and functions of CD8+ T cells in the search for new potential targets against TB.

Methods

We conducted differential expression genes analysis and CD8+ T cell functional gene analysis on 92 TB samples and 61 healthy individual (HI) samples from TB database GSE83456, which contains data on 34,603 genes. The GSE54992 dataset was used to validated the findings. Additionally, a cluster analysis on single-cell data from primates infected with mycobacterium tuberculosis and those vaccinated with BCG was performed.

Results

The overexpression of LAG-3 gene was found as a potentially important characteristic of both pulmonary TB (PTB) and extrapulmonary TB (EPTB). Further correlation analysis showed that LAG-3 gene was correlated with GZMB, perforin, IL-2 and IL-12. A significant temporal and spatial variation in LAG-3 expression was observed in T cells and macrophages during TB infection and after BCG vaccination.

Conclusion

LAG-3 was overexpressed in TB samples. Targeting LAG-3 may represent a potential therapeutic target for tuberculosis.
Narratives of lingua franca English for transnational mobility
Authors: Gallagher Kay
Published: June 2024

This paper explores, through narrative inquiry, the acquisition and use of English as a lingua franca in the careers of three transnationally mobile managers in the global hotel and hospitality industry. The narratives presented here are interwoven with the context in which the multinational participants were situated at the time of the study: the United Arab Emirates (UAE) which is diversifying economically and socially in preparation for the post-fossil fuel era. In a country where the temporary immigrant population outumbers national citizens, participants’ situated language practices are explored through narratives of their multilingual and translingual repertoires, while focusing on English as a key resource for their self-initiated transnational mobility. These personal stories of the acquisition and use of English as a global language weave a linguacultural web that connects the Gulf region across global space, people, and time. Participants tell of the utility of English for their careers, their multilingual repertoires, and their enjoyment of their temporary working lives in the Emirates. Such voices are seldom heard in the literature.
Decomposition, decoupling and dynamic prediction of carbon emissions from city-level building operations: a case study of the Yangtze River Delta
Authors: Wang Zhuoyao
Published: June 2024

Reducing carbon emissions in the building sector is crucial to achieving carbon peak and carbon neutrality goals. Identifying the influencing factors of carbon emissions from building operations at the city level and predicting carbon peaks is of great significance for developing locally adapted policies. This article examines the spatial and temporal trends of carbon emissions at the building operation stage in the Yangtze River Delta (YRD) region over the last 15 years. This article analyzes the driving factors at a city level using the GDIM method and evaluates the decoupling status of income growth and carbon emissions with the GDIM-based decoupling model. The peak time and peak value of operational carbon emissions in the YRD region are predicted through a combination of scenario analysis and the Monte Carlo method. The research shows that: (1) the total carbon emissions from the building operational stage in the YRD region increased by 163.63%, of residents’ disposable income and energy consumption contributed the most. (2) In terms of decoupling relationship between carbon emissions and income growth, rural residential buildings (RR) outperform urban residential buildings (UR) and public buildings (PB). (3) According to the dynamic simulation, the operational carbon emission in the YRD region is expected to peak at 498.18–504.83 Mt MtCO2 between 2030 and 2035. (4) The peak of PBs and URs in Nanjing, Suzhou and some third- and fourth-tier cities, and RRs in eastern and central cities in the YRD will occur at the latest, necessitating close monitoring. These findings can serve as a basis for developing scientific and reasonable building emission reduction policies in a multilevel governance context.
Maximizing hydropower station safety against earthquake through extreme learning machine-enabled shear waves velocity prediction
Authors: Song Tao , Guan Di , Wang Zhen , Ghorbani Hamzeh
Published: June 2024

Hydropower stations are important infrastructures for generating clean energy. However, they are vulnerable to natural disasters such as earthquakes, which can cause severe damage and even lead to catastrophic failures. Therefore, it is essential to develop effective strategies for maximizing hydropower station safety against earthquakes. To evaluate the potential shear rate of surrounding rock layers, the shear wave velocity (Vs) parameter can be used as a useful tool. This parameter helps to determine the velocity at which shear waves travel through the rock layers, which can indicate their stability and susceptibility to earthquakes. This study will investigate the significance of the Vs parameter in evaluating the potential shear rate of rock layers surrounding hydropower stations and how it can be used to ensure their safety and efficiency in earthquake-prone regions. Furthermore, a novel approach is proposed in this research, which involves using extreme learning machine (ELM) technology to predict Vs and enhance the seismic safety of hydropower stations. The ELM model predicts the Vs of the soil layers around the hydropower station, a crucial factor in determining the structure’s seismic response. The predicted Vs is then used to assess seismic hazard and design appropriate safety measures. The ML-ELM model outperformed both the ELM and empirical models, with an RMSE of 0.0432 μs/ft and R2 of 0.9954, as well as fewer outlier data predictions. This approach shows promise for predicting Vs in similar environments, and future research could explore its effectiveness in other datasets and practical applications.
A comparative analysis of RNA-Seq and NanoString technologies in deciphering viral infection response in upper airway lung organoids
Authors: Rezapour Mostafa , Walker Stephen J. , Ornelles David A. , Niazi Muhammad Khalid Khan , McNutt Patrick M. , Atala Anthony , Gurcan Metin Nafi
Published: June 2024

In this study, we delved into the comparative analysis of gene expression data across RNA-Seq and NanoString platforms. While RNA-Seq covered 19,671 genes and NanoString targeted 773 genes associated with immune responses to viruses, our primary focus was on the 754 genes found in both platforms. Our experiment involved 16 different infection conditions, with samples derived from 3D airway organ-tissue equivalents subjected to three virus types, influenza A virus (IAV), human metapneumovirus (MPV), and parainfluenza virus 3 (PIV3). Post-infection measurements, after UV (inactive virus) and Non-UV (active virus) treatments, were recorded at 24-h and 72-h intervals. Including untreated and Mock-infected OTEs as control groups enabled differentiating changes induced by the virus from those arising due to procedural elements. Through a series of methodological approaches (including Spearman correlation, Distance correlation, Bland-Altman analysis, Generalized Linear Models Huber regression, the Magnitude-Altitude Score (MAS) algorithm and Gene Ontology analysis) the study meticulously contrasted RNA-Seq and NanoString datasets. The Magnitude-Altitude Score algorithm, which integrates both the amplitude of gene expression changes (magnitude) and their statistical relevance (altitude), offers a comprehensive tool for prioritizing genes based on their differential expression profiles in specific viral infection conditions. We observed a strong congruence between the platforms, especially in identifying key antiviral defense genes. Both platforms consistently highlighted genes including ISG15, MX1, RSAD2, and members of the OAS family (OAS1, OAS2, OAS3). The IFIT proteins (IFIT1, IFIT2, IFIT3) were emphasized for their crucial role in counteracting viral replication by both platforms. Additionally, CXCL10 and CXCL11 were pinpointed, shedding light on the organ tissue equivalent’s innate immune response to viral infections. While both platforms provided invaluable insights into the genetic landscape of organoids under viral infection, the NanoString platform often presented a more detailed picture in situations where RNA-Seq signals were more subtle. The combined data from both platforms emphasize their joint value in advancing our understanding of viral impacts on lung organoids.
What are the experiences of medical students and their trainers regarding undergraduate training in primary health care at four South African medical schools? A qualitative study
Authors: Mabuza Langalibalele Honey , Moshabela Mosa
Published: June 2024

Background

In 1978, the World Health Organization (WHO) adopted primary health care (PHC) as the most effective strategy to meet the healthcare needs of communities. This raises the question as to the extent and nature of the training that undergraduate (UG) medical students receive in medical schools regarding PHC, following this statement.

Aim

The study aim was to explore the experiences of UG medical students and their trainers regarding training in PHC in their institutions.

Methods

A qualitative study was conducted among UG medical students (MBChB 4-6) and their trainers at four conveniently selected South African medical schools. A total of 16 focus group discussions (FGDs) and 27 in-depth interviews were conducted among students and their trainers, respectively. The MAXQDA 2020 (Analytics Pro) software program was used to arrange the data, resulting in 2,179 data segments, from which categories, sub-themes and themes were derived.

Results

Both the UG medical students and their trainers regarded PHC as mainly an approach to health rather than a level of care. Students were trained by specialists and generalists, received training in the undifferentiated patient, coordinated, comprehensive and continuity of care. The training in tertiary centers, conducted mainly by specialists, the implicitness of the training and the inadequacy of trainers at the PHC settings presented challenges.

Conclusion

Students and their trainers experienced UG student training in PHC in line with the internationally recognized principles on the subject. The view by students and their trainers that PHC is an approach rather than a level of care enhanced its training across disciplines. The implicitness of the training and the tertiary learning platforms were the main challenges experienced. For optimum PHC training, more time should be dedicated to distributed training platforms with supportive specialist outreach programs in the South African medical schools.
African swine fever virus structural protein p17 inhibits IRF3 activation by recruiting host protein PR65A and inducing apoptotic degradation of STING
Authors: Wang Shimin , Xiang Zhiyong , Gao Peng , Zhang Yongning , Zhou Lei , Ge Xinna , Guo Xin , Han Jun , Yang Hanchun
Published: June 2024

African swine fever virus (ASFV) is notoriously known for evolving strategies to modulate IFN signaling. Despite lots of efforts, the underlying mechanisms have remained incompletely understood. This study concerns the regulatory role of viral inner membrane protein p17. We found that the ASFV p17 shows a preferential interaction with cGAS-STING-IRF3 pathway, but not the RIG-I-MAVS-NF-κB signaling, and can inhibit both poly(I:C)- and poly(A:T)-induced activation of IRF3, leading to attenuation of IFN-β induction. Mechanistically, p17 interacts with STING and IRF3 and recruits host scaffold protein PR65A, a subunit of cellular phosphatase PP2A, to down-regulate the level of p-IRF3. Also, p17 targets STING for partial degradation via induction of cellular apoptosis that consequently inhibits activation of both p-TBK1 and p-IRF3. Thus, our findings reveal novel regulatory mechanisms for p17 modulation of IFN signaling and shed light on the intricate interplay between ASFV proteins and host immunity.
The effect of microvascular decompression of the CN IX-X root entry/exit zone and the ventrolateral medulla in neurogenic hypertension involving the vertebral/basilar artery
Authors: Zeng Defeng , Wang Shiyao , Wei Xingrong , Zhang Shuguang , Zhou Hao , Hu Xueqian , Fu Xin , Li Yang , Wei Zhenqing
Published: June 2024

Introduction

Neurogenic hypertension (HTN) is a type of HTN characterized by increased activity of the sympathetic nervous system. Vascular compression is one of the pathogenic mechanisms of neurogenic HTN. Despite Jannetta's solid anatomical and physiological arguments in favor of neurogenic HTN in the 1970's, the treatment for essential HTN by microvascular decompression (MVD) still lacks established selection criteria. Therefore, the subjects selected for our center were limited to patients with primary trigeminal neuralgia (TN) and primary hemifacial spasm (HFS) of the vertebral/basilar artery (VA/BA) responsible vessel type coexisting with neurogenic HTN who underwent MVD of the brainstem to further explore possible indications for MVD in the treatment of neurogenic HTN.

Methods

A retrospective analysis of 63 patients who were diagnosed with neurogenic HTN had symptoms of HFS and TN cranial nerve disease. Patients were treated at our neurosurgery department from January 2018 to January 2023. A preoperative magnetic resonance examination of the patients revealed the presence of abnormally located vascular compression in the rostral ventrolateral medulla (RVLM) and the root entry zone (REZ) of the IX and X cranial nerves (CN IX- X).

Results

There was no significant difference between the two groups in terms of gender, age, course of HFS, course of TN, course of HTN, degree of HTN, or preoperative blood pressure. Based on the postoperative blood pressure levels, nine out of 63 patients were cured (14.28%), eight cases (12.70%) showed a marked effect, 16 cases (25.40%) were effective, and 30 cases were invalid (47.62%). The overall efficacy was 52.38%. However, 39 cases of combined cranial nerve disease were on the left side of the efficacy rate (66.67%) and 24 cases of combined cranial nerve disease were on the right side of the efficacy rate (29.16%).

Discussion

Over the last few decades, many scholars have made pioneering progress in the clinical retrospective study of MVD for neurogenic hypertension, and our study confirms the efficacy of MVD in treating vertebral/basilar artery-type neurogenic hypertension by relieving the vascular pressure of RVLM. In the future, with the development and deepening of pathological mechanisms and clinical observational studies, MVD may become an important treatment for neurogenic hypertension by strictly grasping the surgical indications.

Conclusion

MVD is an effective treatment for neurogenic HTN. Indications may include the following: left-sided TN or HFS combined with neurogenic HTN; VA/BA compression in the left RVLM and REZ areas on MRI; and blood pressure in these patients cannot be effectively controlled by drugs.
Neuroprotective effects of flavonoids: endoplasmic reticulum as the target
Authors: Amiri Bita , Yazdani Tabrizi Maryam , Naziri Mahdyieh , Moradi Farzaneh , Arzaghi Mohammadreza , Archin Iman , Behaein Fatemeh , Bagheri Pour Anahid , Ghannadikhosh Parna , Imanparvar Saba , Akhtari Kohneshahri Ata , Sanaye Abbasi Ali , Zerangian Nasibeh , Alijanzadeh Dorsa , Ghayyem Hani , Azizinezhad Arash , Ahmadpour Youshanlui Mahya , Poudineh Mohadeseh
Published: June 2024

The incidence of neurological disorders, particularly age-related neurodegenerative pathologies, exhibits an alarming upward trend, while current pharmacological interventions seldom achieve curative outcomes. Despite their diverse clinical presentations, neurological diseases often share a common pathological thread: the aberrant accumulation of misfolded proteins within the endoplasmic reticulum (ER). This phenomenon, known as ER stress, arises when the cell’s intrinsic quality control mechanisms fail to cope with the protein-folding burden. Consequently, misfolded proteins accumulate in the ER lumen, triggering a cascade of cellular stress responses. Recognizing this challenge, researchers have intensified their efforts over the past two decades to explore natural compounds that could potentially slow or even reverse these devastating pathologies. Flavonoids constitute a vast and heterogeneous class of plant polyphenols, with over 10,000 identified from diverse natural sources such as wines, vegetables, medicinal plants, and organic products. Flavonoids are generally divided into six different subclasses: anthocyanidins, flavanones, flavones, flavonols, isoflavones, and flavonols. The diverse family of flavonoids, featuring a common phenolic ring backbone adorned with varying hydroxyl groups and additional modifications, exerts its antioxidant activity by inhibiting the formation of ROS, as evidenced by research. Also, studies suggest that polyphenols such as flavonoids can regulate ER stress through apoptosis and autophagy. By understanding these mechanisms, we can unlock the potential of flavonoids as novel therapeutic agents for neurodegenerative disorders. Therefore, this review critically examines the literature exploring the modulatory effects of flavonoids on various steps of the ER stress in neurological disorders.
Association of circulating minerals and vitamins with pregnancy complications: a Mendelian randomization study
Authors: Xie Yuan , Zhang Jie , Ni Shuang , Li Ji
Published: June 2024

Background

Though considerable studies suggesting connections between micronutrients and pregnancy complications, current evidence remains inconsistent and lacks causative confirmation. Our study aimed to explore the causal links between them with a two-sample Mendelian randomization (MR) analysis.

Methods

Genome-wide association studies (GWAS) data for circulating micronutrients were sourced from GWAS Catalog consortium and PubMed, while data for pregnancy outcomes, including gestational diabetes mellitus (GDM), gestational hypertension (GH), spontaneous abortion (SA), preterm birth (PTB), and stillbirth (SB), were retrieved from the UK Biobank and FinnGen consortia. Causal effects were appraised using inverse variance weighted (IVW), weighted median (WM), and MR-Egger, followed by sensitivity analyses and meta-analysis for validation.

Results

Genetically predicted higher vitamin E (OR = 0.993, 95% CI 0.987–0.998; p = 0.005) levels were inversely associated with SA risk. Consistent results were obtained in meta-analysis (OR = 0.99, 95% CI 0.99–1.00; p = 0.005). Besides, a potential positive causality between genetic predisposition to vitamin B12 and SB was identified in both IVW (OR = 0.974, 95% CI 0.953–0.996; p = 0.018) and WM analysis (OR = 0.965, 95% CI 0.939–0.993; p = 0.013). However, no causal relationships were observed between other analyzed circulating micronutrients and pregnancy complications.

Conclusion

This study offers compelling evidence of causal associations between circulating levels of vitamins E, B12 and the risk of SA and SB, respectively. These findings are pivotal for pregnancy complications screening and prevention, potentially guiding clinical practice and public health policies toward targeted nutritional interventions.