bluuebunny/crossref_metadata_2025 huggingface dataset:
PHYSICAL CHARACTERIZATION OF IN SITU OPHTHALMIC GEL: A CONCISE REVIEW
Authors: KURNIAWANSYAH INSAN SUNAN , SOPYAN IYAN , REFSI GENI
Published: January 2022

In situ ophthalmic gel is a type of eye drug preparation that has a higher bioavailability value and has a longer contact time with maximum therapeutic effect and with minimal side effects compared to conventional eye preparations. The preparation of ophthalmic in situ gel is required characterization to make sure that the prepared preparations meet the standards and are safe when used. This journal review aims to look at the methods used in characterizing physical properties in in situ ophthalmic gel formulations with different active substances such as rheology studies, organoleptic tests, pH, clarity, and gelling capacity. In order to get the best formulation of in situ ophthalmic gel preparations so as to provide maximum therapeutic effect.
Neuroetica y neuroderechos
Authors: Cáceres Nieto Enrique , Diez García Javier , García García Emilio
Published: January 2022

Las relaciones entre neurociencia y ética conforman un complejo campo de investigación interdisciplinario, denominado neuroética. Analizamos la neuroética en su doble dimensión: Ética de la neurociencia, que se ocupa de los problemas éticos, y sociales, asociados a la investigación y aplicaciones de la neurociencia; Neurociencia de la ética, que investiga los sistemas neurales, así como los procesos mentales que están a la base de la intuiciones, juicios y comportamientos morales. En forma análoga a la neuroética, el neuroderecho se ocupa de la regulación jurídica de la investigación y práctica neurocientífica; el papel de las neurociencias en el razonamiento probatorio; y el estudio de la actividad neurocognitiva de los operadores jurídicos. Desde la Ética de la neurociencia, proponemos cinco Neuroderechos, cuyo objetivo es impedir que los Derechos Humanos se vean afectados por la aplicación de avances neurocientíficos: Derecho a la preservación de la identidad personal, Derecho a la no interferencia en la libertad de decisión, Derecho a la privacidad de datos neuronales, Derecho a la equidad en el mejoramiento de la capacidad cerebral, Derecho a la protección frente a los sesgos de los algoritmos. Asimismo, proponemos que dichos derechos sean positivizados mediante su incorporación a Tratados internacionales, como parte de una cuarta generación de Derechos Humanos y sean desarrollados a nivel legislativo. De esta manera se agrega al derecho de las neurociencias una nueva tarea: la de implementar la protección jurídica de lo que podríamos llamar “neuroderechos humanos”.
La convención constitucional chilena y el constituyente originario
Authors: Cárdenas Gracia Jaime
Published: January 2022

Durante los años 2021 y 2022 la Convención Constitucional de Chile aprobará para ese país un nuevo texto constitucional que será sometido a la aprobación final de los ciudadanos mediante un plebiscito. Ese proceso constituyente ha sido motivado por los deseos de muchos ciudadanos chilenos para dejar atrás los vestigios de la dictadura de Pinochet y porque han entendido que la Constitución vigente produce un marco de dominación que no es compatible con la democracia ni con los derechos humanos. En 2019 se aprobó una modificación constitucional para normar el proceso constituyente, lo que nos provoca cuatro reflexiones pensando en la realidad mexicana: si todos los constituyentes deben ser electos democráticamente en un proceso de esa naturaleza, si es importante contar con un doble plebiscito en los procesos constituyentes, en dónde reside el constituyente originario, y qué trascendencia tiene el derecho constitucional transitorio.
La jurisprudencia axiológica y el estado social de derecho: sobre las bases de la jurisdicción constitucional en Colombia
Authors: Garzón Cárdenas Ricardo
Published: January 2022

La Sentencia T-406 de 5 de junio de 1992 es el inicio de la jurisdicción constitucional en Colombia. Esta decisión fundó las bases de la jurisprudencia de la Corte Constitucional en temas trascendentes como el concepto de Estado social de derecho, la identificación y el contenido de los derechos fundamentales, la tipología de normas constitucionales, la interpretación constitucional, el papel del juez y del legislador en el nuevo modelo de Estado y la exigibilidad de derechos de contenido social. Este trabajo, con el pretexto del análisis de la sentencia, revisa las implicaciones que ciertos constructos teóricos, como la jurisprudencia de valores y la teoría de los principios de Alexy, tienen sobre la jurisdicción y la interpretación constitucional. Las definiciones conceptuales de esta sentencia se han convertido en tópicos doctrinales, por lo que su análisis equivale a observar en la práctica los conceptos que guían la actual justicia constitucional en Colombia.
La navaja de ockham: el problema del reconocimiento de entes normativos en la filosofía del derecho
Authors: Uscanga Barradas Abril
Published: January 2022

El objetivo general de esta investigación consiste en determinar si la teoría de la navaja de Ockham podría aplicarse válidamente desde el enfoque de las teorías jurídicas contemporáneas, especialmente considerando el debate actual referente a la necesidad de establecer la multiplicidad de entes normativos para explicar el Derecho. En este sentido, analizaremos si el Derecho debe ser comprendido desde la plenitud o la simplicidad, es decir, desde las diferentes visiones teóricas que postulan la existencia de normas y otros estándares, como los principios. Es así que, la navaja de Ockham nos ayudará a entender el Derecho desde la simplicidad o la economía del pensamiento postulado a través el principio non sunt ponenda plura ubi pauciora sufficiunt o entia non sunt multiplicanda sine necesitate.
Discusiones y etapas en torno a “quien se mata a sí mismo” y al “suicidio”, su confluencia en el caso mexicano y la pertinencia de crear un nuevo derecho humano: el derecho a la muerte digna
Authors: Téllez G. Mario A.
Published: January 2022

Este trabajo tiene como objetivo hacer un acercamiento, breve y episódico, a los cambios que ha sufrido la acción de quien se causa la muerte a sí mismo, a la luz de la historia del Derecho, así como a la discusión —que hay en México— del tema en la actualidad, así como a plantear la sustitución parcial de la expresión “suicidio” por el de “derecho a la muerte digna” como un nuevo derecho humano. De igual manera se concluye con un par de ideas que reflejan parte de nuestra reflexión respecto de la decisión de terminar con la propia vida.
Los regímenes extraordinarios derivados de la reforma constitucional energética de 2013: el caso de la electricidad
Authors: Bolívar Meza Martha Laura , Rodríguez Garduño Rogelio Zacarías
Published: January 2022

En el presente artículo se expone el procedimiento legal y constitucional desde la década de los 90´s, mediante el cual se fue reconfigurando el sector energético de una visión pública de Estado rector hacia una visión tendente a la privatización, con el abandono de la política de mantener el dominio y la soberanía en el sector para el Estado Mexicano, mediante y reformas a leyes secundarias y la emisión de reglamentos, y finalmente formalizándose en la reforma constitucional de 2013, a través de tres ejes: 1) el replanteamiento del régimen de propiedad, 2) la trasmutación de lo público en privado, y 3) la aplicación de principios de gobierno corporativo de las empresas privadas hacia las empresas públicas. Al final, se analiza cómo estas modificaciones han impactado el sector eléctrico y a la Comisión Federal de Electricidad (CFE).
A Survey on Ransomware Malware and Ransomware Detection Techniques
Authors: Yadav Sonal
Published: January 2022

Abstract: is a kind of malignant programming (malware) that takes steps to distribute or hinders admittance to information or a PC framework, for the most part by scrambling it, until the casualty pays a payoff expense to the assailant. As a rule, the payoff request accompanies a cutoff time. Assuming that the casualty doesn't pay on schedule, the information is gone perpetually or the payoff increments. Presently days and assailants executed new strategies for effective working of assault. In this paper, we center around ransomware network assaults and study of discovery procedures for deliver product assault. There are different recognition methods or approaches are accessible for identification of payment product assault. Keywords: Network Security, Malware, Ransomware, Ransomware Detection Techniques
A Review on AWS - Cloud Computing Technology
Authors: Kewate Neha
Published: January 2022

Abstract: Cloud computing is something simple we can define as maintaining data centers and data servers and also u can access technology services by computing power, storage, and database using cloud computing technology AWS(Amazon Web Services). It is an emerged model which is already popular among almost all enterprises. It provides us the concept of ondemand services where we are using and scaling cloud resources on demand and as per demand respectively. AWS Cloud computing is a cost-effective model. The major concern in this model is Security and Storage in the cloud. This is one of the major reasons many enterprises of choosing AWS cloud computing. This paper provides a review of security research in the field of cloud security and storage services of the AWS cloud platform. After security and storage, we have presented the working of AWS (Amazon Web Service) cloud computing. AWS is the most trusted provider of cloud computing which not only provides excellent cloud security but also provides excellent cloud storage services. The main aim of this paper is to make cloud computing storage and security a core operation and not an add-on operation. As per the increase in the Service provider and related companies, this AWS Cloud Platform plays a vital role in service industries by giving its best web services, so, therefore, choosing the cloud service providers wisely is the basic need of the industry. Therefore we are going to see how AWS fulfills all these specific needs. Keywords: Trusted Computing, AWS, Information-Centric Security, Cloud Storage, S3, EC2, Cloud Computing
Non-Verbal (Sign Language) To Verbal Language Translator Using Convolutional Neural Network
Authors: Yerpude Poonam
Published: January 2022

Abstract: Communication is very imperative for daily life. Normal people use verbal language for communication while people with disabilities use sign language for communication. Sign language is a way of communicating by using the hand gestures and parts of the body instead of speaking and listening. As not all people are familiar with sign language, there lies a language barrier. There has been much research in this field to remove this barrier. There are mainly 2 ways in which we can convert the sign language into speech or text to close the gap, i.e. , Sensor based technique,and Image processing. In this paper we will have a look at the Image processing technique, for which we will be using the Convolutional Neural Network (CNN). So, we have built a sign detector, which will recognise the sign numbers from 1 to 10. It can be easily extended to recognise other hand gestures including alphabets (A- Z) and expressions. We are creating this model based on Indian Sign Language(ISL). Keywords: Multi Level Perceptron (MLP), Convolutional Neural Network (CNN), Indian Sign Language(ISL), Region of interest(ROI), Artificial Neural Network(ANN), VGG 16(CNN vision architecture model), SGD(Stochastic Gradient Descent).
ELECTROMYOGRAPHY (EMG): A BIO-MEDICAL TECHNIQUE USED FOR ACQUIRING DATA DURING MASTICATION OF FOOD
Authors: Rustagi Sarvesh
Published: January 2022

The main objective of this study was to understand the technique of Electromyography. In this technique activities of muscles were governed on the basis of generated my electrical signals. Electromyography instrumentation consists of data acquisition unit, Universal interface module, Connector, adaptor and software. Various parameters like chew number, mastication time, total burst duration, total muscle activity, burst duration, inter burst duration, cycle time, muscle activity and amplitude were used for analyzing the data acquired during mastication of food at entire mastication, per chew and at three different stages (early, middle and late) of mastication.
EXPLORING APPROPRIATE EXERCISES FOR REHABILITATION IN A POST-STROKE PATIENT WITH IHD AND HYPOTHYROIDISM
Authors: Kariya Sakshi
Published: January 2022

According to a systemic analysis conducted in 2017, the blunt stroke incidence in various parts of India ranged from 44.29 to 559 per 100,000 people over the previous two decades. Stroke is the sudden loss of any neurological function due to a disturbance of blood flow. The majority of stroke victims suffer from long-term disability. We present the case of a 72-year-old woman who was admitted to the hospital with symptoms of fatigue on the left side of her body and facial palsy on the left side, on further assessment it was found that patient had coronary artery bypass grafting before 10 years with no post-operative complications and also had a history of hypothyroidism, this brings about the suspicion about the correlation between the stroke with the history of IHD and hypothyroidism. To manage these passive movements breathing exercises, bed mobility exercises, strengthening exercises followed by gait training was given which was highly effective to make the patient independent and return to her daily activities
REHABILITATION OF STROKE IN CYANOTIC CONGENITAL SINGLE VENTRICLE HEART DEFECT PATIENT
Authors: Dadgal Ragini
Published: January 2022

Congenital heart disease consists of various conditions including tetralogy of Fallot, ventricular septal defect, Epstein’s anomaly, single ventricle, etc. Among these single ventricles is one of the gravest forms of cyanotic congenital heart disease. The cardiac diagnosis is associated with an increased risk of stroke among children. Pediatric arterial ischemic stroke (AIS) is an important cause of neurologic disease in children causing disability. The 14-year-old patient came to the hospital was presented with left side hemiplegia with severe exercise intolerance due to congenital heart disease. The patient has been advised to undergo Fontan procedure for single-ventricle condition 3 years back, but due to poor socioeconomic status, parents of patients refused to do so. The primary goal was to improve bed mobility and trunk balance without developing symptoms of exercise intolerance. The intervention was started with deep and segmental breathing exercises. Proprioceptive neuromuscular facilitation and constrained induced movement therapy were added in the program in addition to passive and active movements, bed mobility, functional reeducation, trunk control exercises, and balance exercises. Combinations of all of the above therapeutic approaches lead to increased functional independence in the patient. This case reports the effectiveness of a rehabilitation program for pediatric arterial ischemic stroke with preventive guidelines for exercise intolerance.
QUANTIFYING FACIAL EXPRESSION USING ARTIFICIAL INTELLIGENCE IN CLASS 1 MOLAR RELATIONSHIP: A NOVEL RESEARCH PROTOCOL
Authors: Raut Akshata
Published: January 2022

Precise face detection analysis is a crucial element for a social interaction review. To the viewer, producing the facial features that correspond to the thoughts and feelings which succeed in arousing the sensation or enhancing of the emotional sensitivity. The study is based on Virtual Reality (VR), to evaluate facial expression using Azure Kinect in adults with Class I molar relationship. The study will be conducted in Human Research Lab, on participants with Class I molar relationship, by using Azure Kinect. 196 participants will be selected of age above 18 as per the eligibility criteria. This research would demonstrate the different tools and applications available by testing their precision and relevance to determine the facial expressions.
EFFICACY OF BRAIN GYM EXERCISES FOR IMPROVING QUALITY OF SLEEP IN PHYSIOTHERAPY STUDENTS
Authors: Seth Nikita H.
Published: January 2022

Human health has suffered a lot as a result of changing times and technological advances. Poor sleep quality affects people of all ages, non- pharmacological solution is increasingly becoming a requirement. Exercises in the brain gym are a good contender in the competition. However, there is still more work to be done before a definitive conclusion can be made about its effectiveness as a intervention. This study aims to evaluate the sleep disturbance and effect of brain gym exercises in improving sleep in the undergraduate physiotherapy students. Here’s idea we suggest to evaluate the sleep disturbance and effect of brain gym exercises as an intervention with duration of practice as 5 days in a week with a section of 25 minutes which is completed in one hour. Insomnia Rating scale is used to get the desired population for giving the intervention and Pittsburgh Sleep Quality Index (PSQI), which has 86.5% specificity and 89.6% sensitivity. The duration of study will be six months. The study design is pre and post interventional study. In this Hypothesis we aim to assess the efficacy of brain gym exercises for improving quality of sleep and treating mild to moderate insomnia. Brain gym exercises are already proved to improve the attention, memory, cognition and provide relaxation. The expected outcome includes detection of sleep disturbances and improvement in sleep quality which will be evaluated using PSQI. Data analysis will be done using students paired t test and conclusion of the study will be published after the results are analyzed.
AN OBSERVATIONAL STUDY ON THE ACCURACY OF HEART RATE READINGS BETWEEN SMART WATCHES AND A HAND HELD VITAL SIGN MONITOR IN STATIC AND DYNAMIC MOTIONS ON A HEALTHY YOUNG ADULT POPULATION
Authors: Fernandes Lynn
Published: January 2022

There are various devices and applications available in the market that can be used to measure heart rates. These are becoming increasingly popular. Amongst these include the Apple watch, the Xiaomi MI Band and using the Thermal Application (T.A.P.) software (used through a Smartphone). In clinical practice and research, usually the E.C.G. Is used to measure the heart rates, (apart from manually counting the beats by palpation). The study will determine the accuracy of using the available devices in the market (previously mentioned), and also determine if they can be used on patients or subjects while sitting and walking, in clinical practice and researches. Method: It will be a comparative observational study. 50 students, selected as per the inclusion and exclusion criteria from Datta Meghe Institute of Medical Sciences will be the subjects of this study. Their heart rates will be monitored with the three devices, and compared with the readings from an E.C.G. It will be done as per Bruce protocol during walking, and in static sitting. The accuracy of the devices will be determined by analyzing the results acquired. The devices are: Apple watch, Xiaomi MI band, and a smart Phone with Thermal Application (T.A.P.) software installed. The successful completion of the study will determine which of the devices show the most accurate heart rate readings, in what positions of a patient (sitting or walking) it would be acceptable to use these devices (in terms of accuracy) in the case where an E.C.G. is not available, or at a time of urgency. The study will also show if it would be appropriate to use these devices in clinical practice and research studies.
PREPARATION, CHARACTERIZATION AND DISSOLUTION STUDY OF SPRAY DRIED SOLID DISPERSIONS OF SIMVASTATIN WITH PVP K25 AND AEROSIL 200
Authors: Singh Pritam
Published: January 2022

BCS class II is well-known for the drugs, having poor aqueous solubility and high permeability. Simvastatin is also categorized as BCS class II, suffering from poor aqueous solubility, affecting its bioavailability. In an attempt to resolve this problem, solid dispersions of simvastatin were prepared by spray-drying method. Solid dispersions of simvastatin with PVP K25 and aerosol in ratio (1:1:1 to 1:5:1) and without aerosil 200 (1:1 to 1:5) were prepared by spray drying method. The dissolution test showed the enhancement of dissolution as compared to the pure drug and nearly equal to marketed formulation “SIMVOTIN 20mg” in both types of formulation, but formulations with aerosil 200 showed faster drug release as compared to the simple formulations without aerosil. The formulation containing the 1:3:1 (simvastatin: PVP K25: Aerosil 200) showed the faster drug release as compared to other formulation that do not contain the Aerosil 200. Other characterization studies were also performed such as FTIR, differential scanning colorimetry and powdered X-ray crystallographic studies. These studies showed the increased amorphous nature of the drug in the formulation, which explain the enhanced dissolution rate of the drug for these formulations.
IN SILICO AND MOLECULAR DYNAMIC STUDIES OF NATURAL FLAVONOIDS FOR THEIR INHIBITORY PATTERN AGAINST INTERLEUKIN-6 (1ALU) AND TNF-Α (5MU8) FOR MANAGEMENT OF ULCERATIVE COLITIS
Authors: Gupta Manish Kumar
Published: January 2022

The search for a prospective lead chemical is a time-consuming and complicated procedure that necessitates a lot of money, patience, and labour. Humans have been using phytochemicals, especially secondary metabolites, for this purpose since ancient times, and they are still on the hunt for even source for drug discovery. Natural flavonoids including rhamnetin, eupatorin, and primuletin are involved in the treatment of numerous biological diseases. The research focuses on molecular docking of 10 flavonoid compounds with the Interleukin-6 (1ALU) and TNF-α (5MU8) to assess the binding affinity at the binding location with the highest binding affinity. The flavonoid-protein complex with the highest binding affinity and interactions was studied using molecular dynamics modelling. With the Interleukin-6 (1ALU) and TNF-α (5MU8), the flavonoid naringin had the lowermost binding energy of 9.8 Kcal/mol. It took 20 nanoseconds to complete and yielded satisfactory results. The rhamnetin, eupatorin, and primuletin residues are more successful at maintaining flavonoid stability against Interleukin-6 (1ALU) and TNF-α (5MU8), according to the overall results of our simulation. These expected results will serve as a starting point for more investigation into the significance of their drug-likeliness properties in the management of ulcerative colitis.
PEDIATRICS ANEMIA: AN APPROACH TOWARDS DIETARY MANAGEMENTS IN A CHILD
Authors: Pattanaik Ananya Anurakta
Published: January 2022

Around the world, anemia affects up to one-half of children younger than five years. The most well-known reason for anemia is not getting enough iron. A child who is anemic does not have enough Red blood cells or enough hemoglobin. Hemoglobin is a protein that lets red blood cells carry oxygen to other cells in the body. Iron is a mineral that carries oxygen in the blood, and is particularly important for children because of their rapid growth. Here in this study our aim is to analyze a young anemia child with all basic parameters and scrutiny in dietary supervision. In initial stage, the child hemoglobin content had become too low and was advised for a Packet red blood cell transfusion 10ml/kg. The patient was taking liquid diet by rigid thermal foil from central therapeutic kitchen. He was taking 50ml into 4 feed 3 hourly. Apart from the therapeutic kitchen iron rich foods such as carrot/ apple/ sorghum/ beet / pomegranate was suggested. We found the patient improvement in biochemical parameters (hemoglobin), the weight was increased by 2.5kg, and platelet count has also become normal. With World Health Organization, other well-known pediatrics organizations have proposed many recommendations for prevention of iron deficiency which is the most common nutritional deficiency in the whole world. Diets with iron, giving iron-rich formulas when breast milk is insufficient, avoiding cow’s milk in the first year of life, screening infants in the 9–12th months in terms of iron deficiency and giving infants iron prophylaxis.
DIETARY MANAGEMENT OF 30% TBSA FLAME BURN PATIENT WITH FACIAL BURN WITH T2DM WITH HTN IN A TERTIARY CARE HOSPITAL
Authors: Das Rupali
Published: January 2022

In developing countries like India, burn injury is as yet a significant and regular reason for mortality and morbidity. Nutrition therapy aims to provide satisfactory and early nourishment to patients experiencing burn injuries. Metabolic help during increased inflammatory state is essential to make sure adequate treatment of burn patients. Nutritional sustain is a fundamental and indispensable part of consume care that requires an aggressive multifaceted approach. Impeded injury, dysfunction of multiple organs, increased chances of infection, and death are largely prevented by an adequate nutrition care along with proper wound management. In this study we detailed a patient having 30% TBSA flame burn with facial burn with T2DM & HTN and observed all require parameter in dietary management. The patient was suggested with high protein, moderate calorie, and moderate fat diet. As the sugar level of the patient was high i.e. ranges between 250-350 mg/dl, 5 ml Insulin was given to him at 3hr interval. With time, along with regular therapeutic diet the patient was took curd, paneer, chena etc. Albumin, globulin, total protein level of the patient was decreased so he also took coconut water, fruit juices (sugar free), milk, vegetable soups etc. As the sugar level of the patient was high i.e. ranges between 150-250 mg/dl, 3ml Insulin was given to him at 6hr interval. The wounds of the patient were started healing and he was active & fresh. The patient undertook a dietary counseling for 17 days and dietary modification was done according to the patient condition.
KETOSIS MANAGEMENT IN A TYPE 2 DIABETES MELLITUS PATIENT: A NUTRITIONAL APPROACH
Authors: Das Rupali
Published: January 2022

Ketosis-inclined type 2 diabetes, an insulin deficiency tends to occur in response to constant hyperglycemia auxiliary to insulin resistance. Hyperglycemia will additionally restrict the secretion of insulin, and a few examinations have even shown a decrease of insulin production at the genetic level by restraining transcription of insulin-producing proteins. Here in this study, we detailed a patient having ketosis in Type 2 Diabetes mellitus and observed all require parameter in dietary management. The patient was found ketone positive in initial days. Due to high level of blood sugar and constipation, he was suggested a diabetic fluid diet and high fiber content meal. Initially Glucose level was 187mg/dl and Hb level- 12.5, after the observation with maintain diet the Hb level- 14.5 and Glucose level was >150mg/dl. Serum proteins and albumin were also found in normal range and the patients found ketone negative in later stage. To date, clinical trials have provided evidence of benefits of Keto diets in terms of clinical outcomes. However, the molecular events responsible for these improvements still remain unclear in spite of the high amount of knowledge on the primary mechanisms of both the diabetes and the metabolic state of ketosis.
DIETARY MANAGEMENT OF CKD IN DIABETIC PATIENT IN A TERTIARY CARE HOSPITAL
Authors: Das Debasmita
Published: January 2022

Chronic kidney disease (CKD) is perhaps the most pervasive entanglements of diabetes, and patients with diabetic kidney disease (DKD) have a considerably higher danger of cardiovascular disease and demise contrasted with their non-diabetic CKD partners. Notwithstanding pharmacologic management procedures, nutritional and dietary mediations in DKD are a fundamental part of the board with the potential for enhancing kidney function decay and forestalling the improvement of opposite of other end-organ complications. In this study we detailed a patient having CKD and observed all require parameter in dietary management. Initial days, the patients Hb level was below normal, so, he was suggested iron-rich foods like beetroot, turnip, and carrot, raw banana in stewed form or in curry form. Also, in later, as the urea and creatinine content of the patient was too high from the normal patient, he was restricted from consuming protein-rich foods. On the day of discharge, all his reports were up to mark except urea and creatinine, as he was renal patient. Although nutrition intervention for DKD does require calculation of macro- and micronutrient and electrolyte requirements, a growing body of evidence suggests that specific dietary patterns of intake may confer additional therapeutic benefit.
COMPARATIVE STUDY ON PREVALENCE AND ASSESSMENT OF ALTERED SENSORIUM AMONG SODIUM ABNORMALITY PATIENTS AT A TERTIARY CARE TEACHING HOSPITAL
Authors: Sharma G.N
Published: January 2022

Altered sensorium or altered level of consciousness is a common complaint among electrolyte abnormality patients and has several synonyms like altered behaviour, generalized weakness, lethargy, agitation, psychosis, disorientation, inappropriate behaviour, inattention, confusion, hallucination. The aim of the study was to evaluate the prevalence and to assess the level of consciousness dysnatremic patients at a tertiary care hospital. A prospective observational study, serum sodium level and other clinical profiles were recorded in a data collection form. GCS was used to analyses the level of consciousness among the enrolled patients. SPSS 22.0 statistical software was used for data analysis. During the study period, a total of 482 patients were enrolled in the study. Based on the serum sodium, they were categorized into Hyponatraemic (410) and Hyponatraemic (72) patients. Our study found a greater number of patients in the age group above 60 years and found that sodium imbalance increases generally in males with increasing age. Our study found that altered sensorium (60%) was predominant more in hyponatremia patients. Chi square test was performed to find statistically significant difference in level of consciousness between hypo and Hyponatraemic patients and was found to be significant p value (≤ 0.05). Abnormalities of plasma sodium are probably the most common electrolyte disorders and they are associated with serious morbidity including a poorer long-term neurologic outcome.
EXCESSIVE INTERNET USE DURING THE COVID-19 PANDEMIC IN A POPULATION OF NORTH LIMA
Authors: Rosa Perez-Siguas
Published: January 2022

Currently, the internet use in conjunction with mobile devices is one of the resources that is increasingly used in the population, however its excess consumption can generate consequences at the mental level of the person. The research objective is to determine the Excessive Internet Use during the COVID-19 pandemic in a population of North Lima. In the results, we observe that, excessive internet use during the COVID-19 pandemic, 67 (59.3%) of the participants have a mild addiction to the internet use and 46 (40.7%) have a moderate addiction to internet use. It is concluded that strategies should be sought to guide parents towards proper management of the Internet use in their children and thus reduce dependence on the Internet use.
ANXIETY IN PREGNANT WOMEN DURING THE COVID – 19 PANDEMIC WHO GO TO A HOSPITAL IN LIMA
Authors: Hernan Matta-Solis
Published: January 2022

Anxiety is one of the factors that affects the mental health of pregnant women during the coronavirus pandemic, due to the physiological and vital changes in their pregnancy. The objective is to determine anxiety in pregnant women during the pandemic of coronavirus who go to a hospital in Lima. It is a quantitative, non-experimental, descriptive cross-sectional study, with a total population of 660 participants, who answered a survey with sociodemographic data and the state-trait anxiety scale. In the results, we observed that during the coronavirus pandemic, 16 (2.4%) of pregnant women presented low anxiety, 555 (84.1%) presented medium anxiety and 89 (13.5%) presented high anxiety. It is concluded psychological interventions are necessary for pregnant women and thus be able to help them during this stage in a safer and more trouble-free way during the coronavirus pandemic.
RESILIENCE DURING THE HEALTH EMERGENCY IN RESIDENTS OF AN UNATTENDED POPULATION IN NORTH LIMA
Authors: Hernan Matta-Solis
Published: January 2022

Resilience is a way of acquiring skills that allow to face situations that compromise its health well-being during the coronavirus pandemic. The research objective is to determine the resilience during the coronavirus pandemic in residents of a vulnerable area of North Lima. The results show the resilience of the residents of a vulnerable area of North Lima, where 13 (1%) have a low resilience level, 413 (30.8%) have medium resilience level and 917 (68.2%) high resilience level. It is concluded that strategies should be promoted on how to maintain mental health at home during the COVID19 pandemic.
DISEASE IDENTIFICATION IN CROPS USING DEEP LEARNING MODELS
Authors: Trisal Adya
Published: January 2022

Food is one of the most fundamental necessities and is crucial for survival. Loss of the food source due to pest infestation attributes towards destroying one-fifth of the yearly worldwide crop yield. The past few decades have witnessed a burgeoning trend of using computerized methods for discerning various diseases found in crops. The main advantage of digitizing the detection process is that it eliminates the errors and miscalculations associated with manual detection. With the advent of Object Detection and Artificial Intelligence, malady detection has not only been rapid but has also maintained the expected level of accuracy. The concepts and models of deep learning have been efficaciously applied and used to identify as well as classify plant diseases. In the scope of this research paper, we present a comprehensive digitized approach to detect plant diseases by utilizing image detection, computer vision, and deep learning models like the Convolutional neural networks, Inception model, and the Visual Geometry Group (VGG16) model. In addition to this, the performance of the above-mentioned models has been evaluated by the virtue of metrics like f1 score, accuracy, precision, and recall.
MALARIA PREDICTION MODEL USING ADVANCED ENSEMBLE MACHINE LEARNING TECHNIQUES
Authors: Adamu Yusuf Aliyu
Published: January 2022

Malaria is a life-threatening disease that leads to death globally, its early prediction is necessary for preventing the rapid transmission. In this work, an enhanced ensemble learning approach for predicting malaria outbreaks is suggested. Using a mean-based splitting strategy, the dataset is randomly partitioned into smaller groups. The splits are then modelled using a classification and regression tree, and an accuracy-based weighted aging classifier ensemble is used to construct a homogenous ensemble from the several Classification and Regression Tree models. This approach ensures higher performance is achieved. Seven different Algorithms were tested and one ensemble method is used which combines all the seven classifiers together and finally, the accuracy, precision, and sensitivity achieved for the proposed method is 93%, 92%, and 100% respectively, which outperformed better than machine learning classifiers and ensemble method used in this research. The correlation between the variables used is established and how each factor contributes to the malaria incidence. The result indicates that malaria outbreaks can be predicted successfully using the suggested technique.
The Sustainable Environmental Protection Deregulation Concept During the Covid-19 Pandemic
Authors: Imamulhadi Imamulhadi
Published: January 2022

The economic recession due to the Covid-19 pandemic has forced several countries to deregulate environmental protection. In response to such policy, many environmental activists and environmentalists worry that deregulation will cause a negative impact on the mitigation of climate change’s effects. Therefore, it is necessary to examine whether or not the deregulation of environmental protection in Indonesia is in line with the objectives of sustainable development. The provisions of the deregulation of environmental protection in Indonesia aims to encourage and accelerate investment through the simplification of licensing procedures, eradicating corruption in the licensing sector, increasing economic growth and gross domestic product, encouraging equitable development, and providing employment opportunities. This study concludes that Indonesia’s deregulation policy does not violate the minimum tolerance standard of environmental protection. It also does not eliminate the precautionary principle and environmental impact analysis as a preventive measure. In addition, it does not revoke environmental quality standards and damage quality standards as monitoring, control, and enforcement instruments. The deregulation accordingly still adheres to the three pillars of sustainable development.
Finite-time boundary stabilization of fractional reaction-diffusion systems
Authors: Zhang Run-Jie , Wang Liming , Wu Kai-Ning
Published: January 2022

This paper investigates the boundary finite-time stabilization of
fractional reaction-diffusion systems (FRDSs). First, a distributed
controller is designed, and sufficient conditions are obtained to ensure
the finite-time stability (FTS) of FRDSs under the designed controller.
Then, a boundary controller is presented to achieve the FTS. By virtue
of Lyapunov functional method and inequality techniques, sufficient
conditions are presented to ensure the FTS of FRDSs via the designed
boundary controller. The effect of diffusion term of FRDSs on the FTS is
also investigated. Both Neumann and mixed boundary conditions are
considered. Moreover, the robust finite-time stabilization of uncertain
FRDSs is studied when there are uncertainties in the system’s
coefficients. Under the designed boundary controller, sufficient
conditions are presented to guarantee the robust FTS of uncertain FRDSs.
Finally, numerical examples are presented to verify the effectiveness of
our theoretical results.
Demographic history and conservation genomics of caribou (Rangifer tarandus) in Québec
Authors: Dedato Morgan , Robert Claude , Taillon Joëlle , Shafer Aaron , Cote Steve
Published: January 2022

The loss of genetic diversity is a challenge many species are facing,
and genomics is a potential tool that can inform and prioritize decision
making. Caribou populations have experienced significant recent declines
throughout Québec, Canada, and some are considered threatened or
endangered. We calculated the ancestral and contemporary patterns of
genomic diversity of five caribou populations and applied a comparative
framework to assess the interplay between demography and genomic
diversity. We calculated a caribou specific mutation rate, μ, by
extracting orthologous genes from related ungulates. Whole genome
re-sequencing was completed on 67 caribou and genotype likelihoods were
estimated. We calculated nucleotide diversity, θπ and estimated the
coalescent or ancestral Ne, which ranged from 12,030 to 15,513. When
compared to the census size, NC, the endangered Gaspésie Mountain
caribou population had the highest Ne:NC ratio which is consistent with
recent work suggesting high ancestral Ne:NC is of conservation concern.
These ratios were highly correlated with genomic signatures (i.e.
Tajima’s D) and explicit demographic model parameters. Values of
contemporary Ne, estimated from linkage-disequilibrium, ranged from 11
to 162, with Gaspésie having among the highest contemporary Ne:NC ratio.
Importantly, conservation genetics theory would predict this population
to be of less concern based on this ratio. Of note, F varied only
slightly between populations, and runs of homozygosity were not abundant
in the genome. Our study highlights how genomic patterns are nuanced and
misleading if viewed only through a contemporary lens; a holistic view
should integrate ancestral Ne and Tajima’s D into conservation
decisions.
Soil organic carbon and iron oxides affects soil aggregate stability under straw returning and potassium fertilizer in a rice--rape cropping system
Authors: Xue Bin , Huang Li , Lu Jianwei , Li Xiaokun , Gao Ruili , Muhammad Kamran
Published: January 2022

Soil organic carbon (SOC) and iron (Fe) oxides are known to affect the
formation and stability of soil aggregates. However, the effects of SOC
and Fe oxides on soil aggregates stability under straw returning and
potassium (K) fertilizer application in paddy–upland rotation systems
are less well-studied. This study primarily investigated soil aggregates
dynamics and their stability indices (mean weight diameter, MWD;
geometric mean diameter, GMD), and soil binders (SOC and iron oxides)
after rice and rape harvests under four treatments: F1，mineral nitrogen
(N) and phosphorus (P) fertilizer; F2, mineral NPK fertilizer; F3,
mineral NP fertilizer with straw returning; F4, mineral NPK fertilizer
with straw returning in rice–rape cropping system. Straw returning
treatments (F3 and F4) significantly (P <0.05) increased MWD
and GMD, but the effect of K is not obvious. The soil aggregates
stability was higher after the rape harvest than rice harvest, but SOC
content was the opposite. Straw input can increase the contents of SOC,
alkane-C and aromatic-C concentrations, especially in >0.25
mm aggregates. Long-term straw incorporation significantly increased the
amorphous (Feo) and complex iron oxides (Fep) concentrations. SOC and
Fep in bulk soil and >5 mm aggregates were significantly
related with MWD, and significant relationship was observed between MWD
and Feo in <5 mm fractions. Thus, the high levels of SOC,
alkane-C, Feo and Fep in soil after straw returning were responsible for
the aggregate stability, but the effect of potassium application is not
obvious in a rice–rape cropping system.
Fecal microbiota and diet compositions of muskox female adults and calves
Authors: Cheon Ji-Yeon , Cho Hyunjoon , Kim Mincheol , Park Hyun Je , Park Tae-Yoon , Lee Won Young
Published: January 2022

Gut microbiome is vertically transmitted by maternal lactation at birth
in mammals. In this study, we investigated the gut microbiome and diet
compositions of muskox, a large herbivore in the high Arctic. From
muskox feces in Ella Island, East Greenland, we compared the microbiota
composition using bacterial 16S rRNA gene sequencing and the dietary
compositions of six female adults and four calves have been compared.
Firmicutes was the most abundant bacterial phylum in both adults and
calves, comprising 94.36% and 94.03%, respectively. There were
significant differences in the relative abundance of two Firmicutes
families: the adults were mainly dominated by Ruminococcaceae (73.90%),
while the calves were dominated by both Ruminococcaceae (56.25%) and
Lachnospiraceae (24.00%). Stable isotope analysis on the feces and
eight referential plant samples in the study area showed that both
adults and calves had similar ranges of 13C and 15N, possibly derived
from the dominant diet plants of Empetrum nigrum and Salix glauca.
Despite the similar diets, the different gut microbiome compositions in
muskox adults and calves indicate that the gut microbiome of the calves
may not be fully colonized yet as much as the one of the adults.
Clinical course of children with chronic suppurative lung disease or bronchiectasis infected with Pseudomonas aeruginosa
Authors: Kartsiouni Elpiniki , Chatzipanagiotou Stylianos , Galani Angeliki , Moriki Dafni , Sardeli Olympia , Prountzos Spyridon , Alexopoulou Efthymia , Mazioti Argyro , Loukou Ioanna , Priftis Kostas , Douros Konstantinos
Published: January 2022

Children with chronic wet cough and without cystic fibrosis (non-CF) may
suffer from chronic suppurative lung disease (CSLD) or bronchiectasis.
Pseudomonas aeruginosa (Pa) can be one of the offending microbes in
these children. The present study aimed to describe the clinical course
of children with the above two conditions who were infected with Pa.
Pengaruh Pemberian Deep Neck Flexor Muscle Activation Terhadap Nyeri Leher: Critical Review
Authors: Apriliani Yusria , Pristianto Arif , Wijianto Wijianto , Wahyuni Wahyuni
Published: January 2022

Latar belakang Nyeri leher menyebabkan penurunan kekuatan otot, dan penurunan daya tahan otot sternocleidomastoid dan deep cervical flexor. Hal itu menyebabkan disfungsi mekanis dan nyeri kronis. Aktivasi deep cervical flexion muscle merupakan bentuk latihan penguatan pada otot, mampu memberikan efek yang signifikan dalam menurunkan nyeri leher. Tujuan penelitian ini bertujuan untuk mengetahui pengaruh pemberian deep neck flexor muscle activation pada nyeri leher Metode metode penelitian critical review dan desain studi randomized controlled trial menggunakan mesin pencarian literatur seperti Pubmed Central (PMC) dan Google Scholar, kemudian dilanjutkan dengan mengidentifikasi jenis Quartile (Q1-3) menggunakan Scimago Journal and Country Rank (SJR) dan penilaian dengan PEDro scale Hasil Sebanyak 9 artikel yang digunakan sebagai landasan penelitian, pada DCF menunjukan penurunan nyeri dengan VAS. Kesimpulannya penelitian menunjukkan adanya pengaruh yang signifikan pada latihan deep neck flexor muscle activation terhadap penurunan nyeri leher pada kondisi nyeri leher kronis maupun non spesifik. Pemberian deep neck flexor muscle activation yang terdiri dari craniocervical flexion, dan cervical stabilizating exercise. Latihan ini dilakukan dengan mendorong kepala kearah belakang dengan menjaga posisi kepala tetap lurus dan diberikan berupa tahanan hingga waktu yang sudah ditentukan Kata kunci nyeri leher, muscle activation, DFC
Penatalaksanaan Fisioterapi Komprehensif Pada Kasus Pasca Coronary Artery By Pass Grafting Et Causa Coronary Artery Disease Involving 3 Vessels (CAD3VD): Case Report
Authors: Pramudiana Nurisma , Pristianto Arif
Published: January 2022

Coronary heart disease is a malfunctioning of the heart caused by stenosis of the heart blood vessels which can affect one or more arteries. In these cases the patient had Triple Vessels Disease (3-VD), where there was ≥50-70% stenosis in most of the main branches of the heart blood vessels, then the patient underwent a revascularization operation Coronary Artery Bypass Grafting (CABG) with a postoperative condition, namely pain. in the sternum and lower right leg, accumulation of pulmonary sputum, decreased thoracic expansion, shortness of breath, decreased activity and functional ability. The management of physiotherapy that is given is chest physiotherapy and active and passive exercises in extremity. After 3 times of therapy, the results obtained from the degree of shortness of T0: 5 to T3: 3, the decrease in pain T0: 6 to T3: 3, then tenderness T0: 6 to T3: 3 and silent pain T0: 4 to T3: 3 increased the difference in thoracic expansion in the axilla T0: 1 cm becomes T3: 2 cm, at ICS T0: 1 cm changes to T3: 2 cm and there has been no increase in the xypoideus process, by 2 cm at T0 and T3. Activity and functional abilities were calculated using the Barthel index on T0 of the total dependency category, changing to T3: weight dependence. Chest physiotherapy and active-passive exercises in extremity can alleviate problems in post-CABG surgery.Keywords: Coronary Artery Bypass Grafting, Chest Physiotherapy, active and pasive exercise in extremity
Implementation of Smart Technologies in the Mine
Authors:   Lviv Polytechnic National University, Butov Maksym , Pavych Tetyana , Paramud Yaroslav
Published: January 2022

The basic methods and principles of mine safety systems have been considered in the paper. The algorithm of one possible smart device (smart helmet) is depicted. This algorithm describes the basic principles of this device. The device allows to find danger in the environment where the miner works, as well as monitors the condition of the miner. It can also quickly analyze this information and report the danger when it is detected. The system has been developed and programmed including basic modules for implementing this algorithm. The results of the comparative analysis of the new system showed an increase in the level of safety by 45% compared to other systems.