bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis and management of mastocytosis: an emerging challenge in applied hematology
Authors: Valent Peter
Published: September 2016

Mastocytosis is a unique and rare neoplasm defined by abnormal expansion and accumulation of clonal mast cells (MCs) in one or multiple organ systems. Most adult patients are diagnosed to have systemic mastocytosis (SM). Based on histological findings and disease-related organ damage, SM is classified into indolent SM (ISM), smoldering SM (SSM), SM with an associated hematologic non-MC-lineage disease (SM-AHNMD), aggressive SM (ASM), and MC leukemia (MCL). The clinical picture, course, and prognosis vary profoundly among these patients. Nonetheless, independent of the category of SM, neoplastic cells usually exhibit the KIT point-mutation D816V. However, in advanced SM, additional molecular defects are often detected and are considered to contribute to disease progression and drug resistance. These lesions include, among others, somatic mutations in TET2, SRSF2, ASXL1, CBL, RUNX1, and RAS. In SM-AHNMD, such mutations are often found in the “AHNMD component” of the disease. Clinical symptoms in mastocytosis result from (1) the release of proinflammatory and vasoactive mediators from MCs, and (2) SM-induced organ damage. Therapy of SM has to be adjusted to the individual patient and the SM category: in those with ISM and SSM, the goal is to control mediator secretion and/or mediator effects, to keep concomitant allergies under control, and to counteract osteoporosis, whereas in advanced SM (ASM, MCL, and SM-AHNMD) anti-neoplastic drugs are prescribed to suppress MC expansion and/or to keep AHNMD cells under control. Novel drugs directed against mutated KIT and/or other oncogenic kinase targets are tested currently in these patients. In rapidly progressing and drug-resistant cases, high-dose polychemotherapy and stem cell transplantation have to be considered.
Pathogen metadata platform: software for accessing and analyzing pathogen strain information
Authors: Chang Wenling E. , Peterson Matthew W. , Garay Christopher D. , Korves Tonia
Published: September 2016

Background

Pathogen metadata includes information about where and when a pathogen was collected and the type of environment it came from. Along with genomic nucleotide sequence data, this metadata is growing rapidly and becoming a valuable resource not only for research but for biosurveillance and public health. However, current freely available tools for analyzing this data are geared towards bioinformaticians and/or do not provide summaries and visualizations needed to readily interpret results.

Results

We designed a platform to easily access and summarize data about pathogen samples. The software includes a PostgreSQL database that captures metadata useful for disease outbreak investigations, and scripts for downloading and parsing data from NCBI BioSample and BioProject into the database. The software provides a user interface to query metadata and obtain standardized results in an exportable, tab-delimited format. To visually summarize results, the user interface provides a 2D histogram for user-selected metadata types and mapping of geolocated entries. The software is built on the LabKey data platform, an open-source data management platform, which enables developers to add functionalities. We demonstrate the use of the software in querying for a pathogen serovar and for genome sequence identifiers.

Conclusions

This software enables users to create a local database for pathogen metadata, populate it with data from NCBI, easily query the data, and obtain visual summaries. Some of the components, such as the database, are modular and can be incorporated into other data platforms. The source code is freely available for download at https://github.com/wchangmitre/bioattribution.
Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus
Authors: Zhang Shuman , Wang Pan , Ren Lili , Hu Chunli , Bi Jing
Published: September 2016

Background

Amyloid-beta (Aβ) plays a key role in Alzheimer’s disease (AD) pathogenesis, and soluble Aβ oligomers are more cytotoxic than Aβ fibrils. Recent evidence suggests that Notch signaling is affected by AD and other brain diseases. Melatonin exerts beneficial effects on many aspects of AD and may protect against myocardial ischemia via Notch1 signaling regulation. Therefore, we hypothesized that the Notch1 signaling pathway is involved in the neuroprotective role of melatonin against soluble Aβ1–42.

Methods

An AD rat model was established via repeated intracerebroventricular administration of soluble Aβ1–42. Melatonin treatment was administered 24 hours prior to Aβ1–42 administration via an intraperitoneal injection. The effects of melatonin on spatial learning and memory, synaptic plasticity, and astrogliosis were investigated. The expression of several Notch1 signaling components, including Notch1, the Notch1 intracellular domain (NICD), Hairy and enhancer of split 1 (Hes1, a downstream effector of Notch), and Musashi1 (a positive regulator of Notch), were examined using immunohistochemistry, western blotting, and quantitative real-time PCR. In vitro studies were conducted to determine whether the melatonin-mediated protection against Aβ1–42 was inhibited by DAPT, an inhibitor of Notch signaling.

Results

Melatonin improved the Aβ1–42-induced impairment in spatial learning and memory, attenuated synaptic dysfunction, and reduced astrogliosis. Melatonin also ameliorated the effects of Aβ1–42 on Notch1, NICD, Hes1, and Musashi1. The in vitro studies demonstrated that DAPT effectively blocked the neuroprotective effect of melatonin against Aβ1–42.

Conclusions

These findings suggest that melatonin may improve the soluble Aβ1–42-induced impairment of spatial learning and memory, synaptic plasticity, and astrogliosis via the Musashi1/Notch1/Hes1 signaling pathway.
Vapor Pressures of Anesthetic Agents at Temperatures Below 0°C and a Novel Anesthetic Delivery Device
Authors: Schenning Katie J. , Casson Henry , Click Sarah V. , Brambrink Lucas , Chatkupt Thomas T. , Alkayed Nabil J. , Hutchens Michael P.
Published: September 2016

At room temperature, the vapor pressures of desflurane, isoflurane, and sevoflurane are well above the clinically useful range. We hypothesized that therapeutic concentrations of these agents could be achieved at temperatures below 0°C, but the vapor pressure–temperature relationship is unknown below 0. Second, we hypothesized that this relationship could be exploited to deliver therapeutic-range concentrations of anesthetic vapor. We therefore set out to determine the low temperature–vapor pressure relationships of each anesthetic agent, thereby identifying the saturated vapor concentration of each agent at any temperature below 0°C. To test our hypothesis, we measured the saturated vapor concentration at 1 atm of pressure for temperatures between −60 and 0°C, thus developing an empiric relationship for each agent. There was consistency in repeated experiments for all 3 agents. To test the empiric data, we constructed a digitally controlled thermoelectric anesthetic vaporizer, characterized the device, and used it to deliver anesthetic vapor to laboratory mice. We report, for the first time, the temperature–vapor pressure relationship at temperatures below 0°C for desflurane, isoflurane, and sevoflurane as well as the TMAC of these agents: the temperature at which the vapor pressure is equal to the minimum alveolar concentration. We describe the construction and limited validation of an anesthetic vaporizer prototype on the basis of this principle. We conclude that clinically relevant concentrations of volatile anesthetics may be achieved at low temperatures.
Bithiophene with Winding Vine-shaped Molecular Asymmetry. Preparation, Structural Characterization, and Enantioselective Synthesis
Authors: Toyomori Yuka , Tsuji Satoru , Mitsuda Shinobu , Okayama Yoichi , Ashida Shiomi , Mori Atsunori , Kobayashi Toru , Miyazaki Yuji , Yaita Tsuyoshi , Arae Sachie , Takahashi Tamotsu , Ogasawara Masamichi
Published: September 2016

Preparation of 2,2′-bithiophene derivatives bearing ω-alkenyl groups at the 3,3′-positions and ring-closing metathesis reactions of the obtained compound were performed. The reaction of bithiophene bearing 3-butenyl substituents 1 with 5 mol % Grubbs 1st generation catalyst underwent ring-closing metathesis (RCM) to afford the cyclized product 7 showing winding vine-shaped molecular asymmetry in up to 88% yield. Enantioselective RCM was also achieved by the use of chiral Schrock–Hoveyda molybdenum-alkylidene catalyst in up to 87% ee.
INTANGIBLE HERITAGE AS A SOCIAL FACTOR OF THE DEVELOPMENT OF URBAN AREAS IN A SERVICE ECONOMY
Authors: Хуснутдинова Светлана , Khusnutdinova Svetlana , Сафонова Мария , Safonova Mariya
Published: September 2016

The article is devoted to study the role of intangible cultural heritage in the development of modern urban areas. Modern cities are experiencing a transformational load associated with the transition from industry to the post-in- dustry – service industry comes on the place of the plants, and one of the leading sectors becomes tourism. Social and environmental factors on the one hand, reflect the general level of development of the city and, on the other hand, in a post-industrial economy are the main actors in the development of all areas, including city tourism. Intangible cultural heritage is seen as a social factor, the formation of which is related to the environment (natural- ecological spheres), and history of the city. Intangible cultural heritage serves as a catalyst for the creative economy and the events of the city, which in turn have a positive impact on city tourism. The city squares, streets, parks are becoming the immediate territorial areas, where the intangible cultural heritage are demonstrated to the citizens and tourists and their level of status, comfort and attractiveness depends largely on the implementation of the tourism potential of the intangible heritage. Cities skillfully combining the intangible heritage, creative industries, event and educational tourism receive an additional impulse for the development of city tourism and the whole economy of the city. The Republic of Tatarstan last decade is actively moving towards the formation of territorial attractive tourism product. Kazan has ranked among the leading cities of domestic tourism sector. Moreover, any tourism city is interested in attracting more tourists for longer periods, which is possible due to the diversity of the program in the city or region. Intangible cultural heritage can play an important role in solving this problem. In the article using the example of the three cities of the republic – Kazan, Chistopol and Elabuga – is shown as a combination of social factors, such as intangible cultural heritage, and natural factors can create an attractive tourism route. Publication of the article was supported by Russian Humanitarian Research Foundation and government of the Republic of Tatarstan as part of scientific project № 15–13–16004.
INTANGIBLE CULTURAL HERITAGE AS AN INNOVATIVE DRIVER OF TOURISM DEVELOPMENT IN A REGION (TRADES AND CRAFTS OF VORONEZH REGION AS AN EXAMPLE)
Authors: Яковенко Наталия , Yakovenko Nataliya
Published: September 2016

In the modern conditions of globalization and the ambiguity of the national identity of countries the increased interest in the cultural tangible and intangible heritage can be seen. This is due primarily to the fact that Russian regions are experiencing the adverse period in the development caused by external sanctions. It led to the fact that tourists are looking for opportunities to spend holidays on the territory of Russia. And in this case, the national artistic trades can be attractive factor of the tourist flow in any region of Russia. National artistic trades are a recognized part of the national culture. Voronezh region is a perspective region for the variety of types of tourism: cultural, educational, medical and health, business, event, ecological, rural and agro-tourism, etc. The relevance of the study of national artistic trades in order to develop a tourist industry is predetermined by the need to develop the regional competitive tourism industry, as well as to achieve the target values of indicators of implementing the Development Strategy of Voronezh region up to2020, in which tourism is one of the basic sectors of the economy. Therefore, the development of national artistic trades, strengthening their role in the socio-economic development of the region, stimulating economic activity of small and medium-sized enterprises, creating favorable conditions for the development of tourism will contribute to the socio- economic growth of the region and attraction of tourists to Voronezh region.
The study was financially supported by RFBR Grant 16–46–360686 р_а.
DEVELOPMENT OF ETHNO-TOURISM IN THE MARI EL REPUBLIC
Authors: Охотина Наталья , Okhotina Natalya
Published: September 2016

In the current crisis the development of domestic tourism is very important. Further promotion of ethno tourism may be a promising and popular trend in the domestic market of tourist services of the regions. In the study, the author exam- ined the characteristics of nature, history, culture and religion of indigenous peoples of Mari land as the most important factors of tourism development in the region. The article presents the analysis of state of ethno tourism in the Mari El Republic. The author outlines the main directions of its development in the region that dip into the cultural environment: ethnographic museums, hotels and recreational facilities with an ethnic flavor, ethno-villages, and rural guest houses. The expert survey in order to identify the prospects for the development of ethno tourism in Mari El has been conducted. The contradictions in the law, inadequate infrastructure in the country, weak advertising campaign to attract tourists to the region, sometimes a lack of interest of local authorities in the development of tourism are the main difficulties in the ethno tourism development. The author suggests ways of further development of ethno tourism in Mari El. It is neces- sary to develop a targeted program for the development of tourism in t Mari El, with an emphasis on ethno tourism.
THE ROLE OF LOCAL COMMUNITIES IN THE PROCESSES INVOLVING THE INTANGIBLE CULTURAL HERITAGE IN TOURISM (BASED ON THE BOLGAR HISTORICAL AND ARCHAEOLOGICAL COMPLEX, TATARSTAN)
Authors: Никонова Татьяна , Nikonova Tatyana , Веслогузова Мария , Vesloguzova Mariya , Муртазина Гульнара , Murtazina Gulnara
Published: September 2016

Mobilising the economic potential of the intangible cultural heritage, using it as the tourist attractions is in modern con- ditions the basis for sustainable development of historical settlements and historic areas. Bolgar Historical and Archaeo- logical complex has passed a period of its formation and now is one of the largest and interesting conservation areas in the Russian Federation. Every year the tourist flow here is growing. Theatrical meeting in national traditions give a unique local flavor and are very popular among tourists. However, museum tourism product experiences a lack of ethnic component; and local population, irritated by mass tourist arrivals, is isolated from its formation. The difficulties, appearing as the result of searching the balance of market participants’ interests, are specific for the culture and tourism development in the whole world. Although the involvement of residents in local cultural projects is less expensive and more sustainable in the long term The problem of introduction of local population to the tourism development and the involvement of the intangible cultural heritage can be solved by the implementation of measures aimed at getting by the local population economic, social, cultural and other benefits. The article deals with the problem of introduction of local population in the processes of tourism development and the involvement of ethnic and cultural intangible heritage in tourist complex. The authors make conclusion about the possibilities of the combination of tangible and intangible components of heritage in Bolgar Historical and Archaeological complex as the prospects of its further development.
THE ROLE OF LOCAL COMMUNITIES IN THE PROCESSES INVOLVING THE INTANGIBLE CULTURAL HERITAGE IN TOURISM (BASED ON THE BOLGAR HISTORICAL AND ARCHAEOLOGICAL COMPLEX, TATARSTAN)
Authors: Кулягина Наталья , Kulyagina Natalya , Матасова Алсу , Matasova Alsu
Published: September 2016

Mobilising the economic potential of the intangible cultural heritage, using it as the tourist attractions is in modern conditions the basis for sustainable development of historical settlements and historic areas. Bolgar Historical and Archaeological complex has passed a period of its formation and now is one of the largest and interesting conservation areas in the Russian Federation. Every year the tourist flow here is growing. Theatrical meeting in national traditions give a unique local flavor and are very popular among tourists. However, museum tourism product experiences a lack of ethnic component; and local population, irritated by mass tourist arrivals, is isolated from its formation. The difficulties, appearing as the result of searching the balance of market participants’ interests, are specific for the culture and tourism development in the whole world. Although the involvement of residents in local cultural projects is less expensive and more sustainable in the long term The problem of introduction of local population to the tourism development and the involvement of the intangible cultural heritage can be solved by the implementation of measures aimed at getting by the local population economic, social, cultural and other benefits. The article deals with the problem of introduction of local population in the processes of tourism development and the involvement of ethnic and cultural intangible heritage in tourist complex. The authors make conclusion about the possibilities of the combination of tangible and intangible components of heritage in Bolgar Historical and Archaeological complex as the prospects of its further development.
Pemanfaatan Antosianin dari Ekstrak Kol Merah (Brassica oleracea var) sebagai Pewarna Dye-Sensitized Solar Cells (DSSC)
Authors: Pratiwi Dinasti Dwi , Suryana Risa , Nuryoshid Fahru
Published: September 2016

A prototype of Dye-Sensitized Solar Cells (DSSC) utilizing anthocyanin extract from red cabbage was fabricated. This study aims to determine the wavelength absorption of dye contributed in highest efficiency. The sandwich structure of DSSC consists of TiO2 as working electrode, carbon layer as counter electrode, anthocyanin dye as photosensitizer, and electrolyte as electron transfer media. The absorbance of dye was characterized using UV-Vis spectrophotometer, the efficiency of DSSC was calculated using I-V Meter Keithley, and the quantum efficiency was characterized using IPCE Measurement System. The absorption of dye anthocyanin of red cabbage is 450 nm–580 nm wavelengths, I-V characteristic curves resulted efficiency of 0,029%, and IPCE characteristic resulted highest efficiency at wavelength of 420 nm with efficiency of 0,099%.
Modifikasi Permukaan Elemen Peredam Bising dengan Profil Berbentuk Prisma
Authors: Kusuma Julius Indra , Harjana H , Yahya Iwan
Published: September 2016

The influence of surface modification by using prism shaped profile on the sound absorption of absorber element was investigated experimentally. A prime number based configuration of the two types opened and closed type rism shaped profile inclusion was tested by using impedance tube according ASTM E1050 standard. The result shows that sound absorption at low frequency band below 200 Hz increased with the increasing of closed prism number. It is related to the coupling effect between the cavities of the absorber element and the prisms that changes reactance of the coupled structure. In the other side, a half wave resonance like effect occur on the use of opened prisms inclusion, which is increase the sound absorption performance at mid to high frequency range between 800 Hz to 1.25 kHz.
Electromagnetics Properties of Non-Relativistic Deuteron in Ground State
Authors: Sari R. Yosi Aprian , Darmawan Denny
Published: September 2016

Proton-neutron interaction that makes up deuteron is a mixture state of 𝑆13 dan 𝐷13, which are each associated with a state 𝐿=0, 𝑆=1 and 𝐿=2, 𝑆=1. In the proton-neutron interaction, there are particle exchanges of medium range (1 fm≤𝑟≤2 fm) i.e. scalar meson exchange and the long range (𝑟>2 fm) i.e. one pion exchange. The electromagnetic properties of non-relativistic deuteron in the ground state can be found from the coupled differential equation, such as magnetic dipole moment, 〈𝜇D〉=0.856521𝜇𝑁 and electrical quadrupole moment, 〈𝑄D〉=0.00291396 b.
Brightening the Mind: The Impact of Practicing Gratitude on Focus and Resilience in Learning
Authors: Wilson Jane Taylor
Published: September 2016

A growing body of groundbreaking research shows that gratitude has the power to heal, energize, and transform lives by enhancing people psychologically, spiritually, physically, and cognitively. This study contributes to the study of gratitude by exploring its impact on focus and resilience in learning. Specifically, this study examines the impact that practicing gratitude has on college students’ ability to focus in class and remain resilient in the face of difficulties while learning.
Método para implementação de planejamento de vendas e operações (S&OP) aplicado em empresa do ramo automotivo
Authors: Kralik Letícia Schumacher , Fogliatto Flávio Sanson
Published: September 2016

O S&OP (Sales and Operation Planning) é um processo estruturado de planejamento de vendas e operações que norteia as decisões com relação às necessidades de produção. Trata-se de um processo colaborativo, que tem por finalidade alinhar diversos setores envolvidos na gestão da demanda, sendo peça principal do mesmo o apoio da alta gerência. O objetivo dessa pesquisa é propor uma metodologia para implementação do processo de S&OP, contemplando o mapeamento do processo e a sequência de atividades necessárias, além de demonstrá-la através da sua aplicação numa empresa automotiva. O método proposto se mostrou eficaz, uma vez que o processo de S&OP foi executado na empresa sem imprevistos e atrasos, e ainda trouxe a padronização da gestão da demanda levando à revisão periódica da quantidade de produtos a serem fabricados. Ainda obtiveram-se ganhos com relação à troca de informações que os encontros promovidos pelo S&OP possibilitaram, bem como o alinhamento entre os diversos setores envolvidos por ele.
Distribuição de propostas de projetos de inovação: fatores de decisão de alo-cação entre equipes de dfss e design thinking
Authors: Lopes Karyn Martinelli , Fleury André Leme , Zancul Eduardo de Senzi
Published: September 2016

A necessidade de adaptação e inovação das empresas faz com que coexistam simultaneamente diversas iniciativas de inovação. Iniciativas de inovação e de melhoria são em geral realizadas por meio de projetos, que empregam abordagens específicas como o Design for Six Sigma (DFSS) e o Design Thinking. O DFSS e o Design Thinking possuem características distintas, mas eventualmente podem ser aplicados em projetos de inovação na mesma organização. Assim, o objetivo deste artigo é explorar os conceitos sobre DFSS e Design Thinking e discutir os fatores de decisão de alocação de projetos entre equipes de DFSS e Design Thinking a partir de um estudo de caso em uma empresa do setor financeiro que utiliza as duas abordagens. Dentre os fatores de decisão de alocação, destacam-se a caracterização dos projetos em tame problems e wicked problems. Os resultados da pesquisa demonstram que tanto projetos DFSS quanto Design Thinking são utilizados para a solução de tame problems. Essa diferença nas características observadas com relação à literatura é decorrente de decisões oriundas da própria empresa para melhor adaptação das abordagens de acordo com as necessidades atuais. O estudo indica que o Design Thinking tende a ser mais efetivo na sua aplicação com visão de futuro focada no cliente, gerando maiores resultados inovadores.
Armadilhas no gerenciamento de riscos de cima para baixo: uma pesquisa-ação em uma empresa de engenharia
Authors: Zheng Esther Zhi Hong , Carvalho Marly Monteiro de
Published: September 2016

O estudo tem como objetivo identificar as falhas na implementação do gerenciamento de riscos, focando tanto nos aspectos hard quanto soft do gerenciamento de riscos. A pesquisa foi baseada em uma pesquisa ação em uma empresa de engenharia que desenvolve projetos em quatro diferentes mercados: hidrocarbonetos, mineração, infraestrutura e meio ambiente, e energia. O resultado mostra a importância do engajamento top-down na implementação do gerenciamento de riscos e, por outro lado, as suas armadilhas, reduzindo o gap entre o que é dito e o que é feito.
Modelo matemático para estruturação do sistema logístico reverso do resíduo sólido urbano para coprocessamento
Authors: Akasaka Yuka , De Almeida D'Agosto Márcio , Mattos Ribeiro Glaydston
Published: September 2016

O sistema logístico reverso do resíduo sólido urbano (RSU) pode se apresentar com várias estruturas. Este trabalho foca na estruturação do método de combustão com recuperação energética pelo coprocessamento, devido à contribuição que este método traz na diminuição do envio de RSU ao aterro sanitário. Com base em uma extensa revisão bibliográfica e avaliação das técnicas de modelagem e dos métodos utilizados na literatura para a resolução de problemas similares, elabora-se um modelo matemático genérico para estruturação do sistema logístico reverso do RSU para coprocessamento. Este modelo pode ser utilizado futuramente para projetar adequadamente este sistema e assim contribuir para a diminuição do descarte de RSU no aterro sanitário.
A coordenação civil-militar na logística humanitária e o papel das forças armadas brasileiras no gerenciamento de desastres
Authors: Rosa Paulo Ricardo Sousa da , Bandeira Renata Albergaria de Mello
Published: September 2016

Este trabalho aborda as normas e conceitos internacionais utilizados na coordenação civil-militar no contexto da logística humanitária, apresentando os tipos de emprego dos meios militares nas diferentes respostas humanitárias; destacando a atuação das Forças Armadas nas operações de resposta a desastres encontrados na literatura acadêmica e analisando os principais desafios e limitações desta coordenação. Também são analisados no artigo as capacidades operacionais e o papel dos militares em operações de resposta a desastres, discutindo-se a atuação das Forças Armadas brasileiras na gestão de desastres, com seus desafios e limitações de coordenação no país, finalizando com recomendações para uma maior eficiência da ação militar na logística humanitária em operações de resposta a desastres.
O que favorece a resiliência na cadeia de suprimentos? Insights a partir de uma revisão sistemática de literatura
Authors: Costa Flávio Henrique de Oliveira , Silva Andrea Lago da , Pereira Carla Roberta
Published: September 2016

Riscos e vulnerabilidades são fatores intrínsecos a qualquer cadeia de suprimentos. Para superar possíveis problemas gerados por rupturas no fluxo de materiais ao longo das cadeias, gestores e pesquisadores estão cada vez mais interessados em explorar fatores internos e externos que auxiliam a geração de resiliência. Nesse contexto, o objetivo deste estudo foi caracterizar os facilitadores à resiliência na cadeia de suprimentos presentes na literatura e analisar suas possíveis inter-relações. Para tanto, utilizou-se como método de pesquisa uma revisão sistemática de literatura. Como resultado, doze facilitadores foram caracterizados e relacionados, formando três grandes grupos: um relacionado ao capital social e ao conhecimento, outro a resposta à ruptura, e um último agrupamento ligado ao relacionamento e a preparação para rupturas. Trabalhos futuros devem buscar responder empiricamente como os facilitadores mapeados contribuem para a geração de resiliência, fazendo uso de casos críticos nacionais como mercados de produtos de alta variabilidade ou perecíveis.
Análise da aplicação da técnica de gerenciamento do valor agregado (EVM) em projetos de construção enxuta
Authors: Cândido Luis Felipe , Carneiro Juliana Quinderé , Heineck Luiz Fernando Mählmann
Published: September 2016

O Gerenciamento do Valor Agregado (Earned Value Management, EVM) ou a Análise do Valor Agregado (Earned Value Analysis, EVA) é uma técnica de medição e controle de projetos baseada na medição física, financeira e de tempo que proporciona indicadores de avanço real, variações de desempenho e previsões para conclusão do projeto. Entretanto, vários trabalhos científicos vêm descrevendo alguns problemas e limitações dessa técnica como a desconsideração dos fluxos de trabalho e a incompatibilidade de previsões em estágios iniciais de construção. Assim, por meio de um estudo de caso único, exploratório e descritivo, o presente trabalho tem por objetivo analisar o uso da técnica do EVM em um projeto de construção sob a ótica da Construção Enxuta. O estudo pode confirmar alguns problemas levantados em outros trabalhos, bem como expandi-los, proporcionando uma visão mais holística sobre a aplicabilidade dessa técnica na construção civil, especialmente em obras cuja construção enxuta é aplicada. Por fim, os autores concluem que a técnica do EVM é uma repetição da técnica de medição físico-financeira plotada no tempo e que suas limitações podem tornar o seu uso incompatível com projetos de construção.
Planejamento da capacidade de produção na indústria plástica: uma abordagem baseada em previsão de demanda e níveis de capacidade
Authors: Almeida Rodrigo Pessotto , Romanzini Fernanda , Werner Liane
Published: September 2016

Este artigo apresenta um estudo da aplicação de conceitos de capacidade de produção e previsão de demanda, voltado a propor soluções para problemas acerca do planejamento da capacidade. O objetivo do estudo é prever o mix de produtos e o nível de atividade prevista que otimiza a utilização da capacidade disponível. Para isso é proposta uma modelagem matemática, que utiliza o algoritmo GRG não linear disponível através da planilha do Microsoft® Excel. A aplicação do modelo é conduzida utilizando dados de uma das principais empresas brasileiras transformadoras de plástico. Os resultados revelam a habilidade do modelo proposto em fornecer informações que auxiliam a tomada de decisões para o planejamento da capacidade de produção.
Otimização via simulação por metamodelagem: um estudo em casos da área médica
Authors: Miranda Rafael de Carvalho , Montevechi José Arnaldo Barra , Pereira Tábata Fernades , Silva Aneirson Francisco
Published: September 2016

O uso combinado da simulação a eventos discretos e otimização vem crescendo nos últimos anos. No entanto, esta forma de otimização ainda é pouco utilizada, devido principalmente a seu elevado custo computacional. Nesse sentido, vários trabalhos visam desenvolver novos métodos de otimização, buscando acelerar este procedimento. Este trabalho faz uso da técnica de metamodelagem, para criar um modelo matemático, que represente uma determinada saída de um modelo de simulação, e proceder com sua otimização sem a necessidade da utilização do modelo simulado. Para exemplificar o método empregado foram utilizados modelos de simulação ligados à área médica. O uso da metamodelagem permitiu otimizar os modelos de simulação, alcançando soluções estatisticamente iguais as encontradas por um otimizador comercial, com a vantagem de reduzir o tempo computacional do processo em mais de 68% em média. Desta forma, a metamodelagem se apresenta como uma potencial técnica de otimização para a simulação, ao prover soluções de elevada qualidade em um tempo computacional reduzido, quando comparado a métodos de otimização via simulação tradicionais.
Simulação computacional para avaliação do impacto ambiental gerado pela tecnologia de informação
Authors: Kroth Giana Lucca , Simonetto Eugênio de Oliveira , Lobler Mauri Leodir , Gubiani Juçara Salette , Schiefelbein UnHee
Published: September 2016

Em um processo irreversível, pessoas e empresas utilizam as Tecnologias de Informação (TI) em diferentes atividades no dia a dia. Essa demanda leva a indústria de tecnologia a uma busca incessante pela inovação e o resultado é um ciclo de melhorias, novidades e o consequente aumento do descarte desses componentes no meio ambiente bem como o aumento do consumo de energia e a emissão de CO² na atmosfera. Nesse contexto, a TI Verde surge como uma alternativa para minimizar os efeitos nocivos ao meio ambiente provocados pela fabricação, uso intensivo e descarte da TI. Uma das barreiras que levam as empresas a adiarem a adoção de práticas da TI Verde é o custo envolvido na implantação e a não garantia do retorno esperado. Assim, fazendo uso da própria TI, através da metodologia de Dinâmica de Sistemas e do software Vensim (VENTANA SYSTEMS, 2015), este trabalho buscou simular a redução do impacto ambiental que a implantação de práticas da TI Verde, tais como a virtualização de servidores e o desligamento dos equipamentos quando não estão em uso, podem trazer, ao longo de dez anos, em uma Unidade de TI de uma universidade. Os resultados demonstram que, com a adoção de práticas simples, é possível atingir uma redução de até 62% no consumo de energia e emissão de CO².
Smartglasses for the Triage of Casualties and the Identification of Hazardous Materials
Authors: Berndt Henrik , Mentler Tilo , Herczeg Michael
Published: September 2016

Emergency Medical Services (EMS) can be confronted with complex and challenging situations with many casualties that require special procedures and organizational structures. In order to keep control and records, incident commanders use paper-based notes, lists and forms. The increasing availability of smartglasses leads to the research question, whether they can support members of EMS and improve processes and efficiency. In this contribution, we describe use cases for smartglasses in emergency medicine, such as the triage in incidents with many casualties and the recognition of hazardous materials in accident contexts. We describe results from interviews with 10 members of EMS and civil protection units in Germany and from prototypical applications that have been developed and evaluated together with domain experts. The prototypical applications described in this contribution have shown promising results with respect to usability and acceptance.
Head-Mounted Displays in German Companies A Virtual, Augmented and Mixed Reality Check
Authors: Esser Ralf , Oppermann Leif
Published: September 2016

In 2020, German companies will spend close to €850 million on Virtual and Mixed Reality hardware and solutions based on smart glasses. The lion’s share will be spent on innovative applications.

This text provides some guidance in this rising market by categorizing the available smart glasses and head-mounted displays into five categories and the potential business application fields into a further eight categories. Finally, it presents a matrix of suitable devices per application field.
Introduction to this Special Issue on Smart Glasses
Authors: Oppermann Leif , Prinz Wolfgang
Published: September 2016

The idea of augmented or virtual reality in combination with head mounted display is being discussed already since at least 1968. However, for a long time, this topic was discussed mainly within the academic research area with only limited effect or uptake in the work place. Primary reason for this was the missing availability of robust and affordable hardware as well as the limited mobile graphics capabilities. This has changed recently with the availability of numerous affordable devices in combination with applications from the entertainment and gaming area.

This Special Issue on Smart Glasses presents a mix of recent research papers and reports to provide an overview of ongoing research and developments in work place environments. In the remainder of this introductory paper we present an overview of the history of Smart Glasses and their applications over the last decades. We also clarify the term Augmented Reality in this historic context. Then we present a topology of current products as well as their intended application areas. Finally, we introduce the papers of this issue within this context.
Dark silicon management: an integrated and coordinated cross-layer approach
Authors: Pagani Santiago , Bauer Lars , Chen Qingqing , Glocker Elisabeth , Hannig Frank , Herkersdorf Andreas , Khdr Heba , Pathania Anuj , Schlichtmann Ulf , Schmitt-Landsiedel Doris , Sagi Mark , Sousa Éricles , Wagner Philipp , Wenzel Volker , Wild Thomas , Henkel Jörg
Published: September 2016

This paper presents an integrated and coordinated cross-layer sensing and optimization flow for distributed dark silicon
management for tiled heterogeneous manycores under a critical temperature constraint. We target some of the key challenges
in dark silicon for manycores, such as: directly focusing on power density/temperature instead of considering simple
per-chip power constraints, considering tiled heterogeneous architectures with different types of cores and accelerators,
handling the large volumes of raw sensor information, and maintaining scalability. Our solution is separated into three
abstraction layers: a sensing layer (involving hardware monitors and pre-processing), a dark silicon layer (that derives
thermally-safe mappings and voltage/frequency settings), and an agent layer (used for selecting the parallelism of
applications and thread-to-core mapping based on alternatives/constraints from the dark silicon layer).
Single Machine Scheduling Based on EDD-SDST-ACO Heuristic Algorithm
Authors: Song Haicao , Yi Shuping , Liu Mi , Qin Gaoyang
Published: September 2016

A large number of changeovers exist in multi-item and small lot size production mode, which lead to a long setup time and significantly influence productivity. However, setup time has received significantly less attention in previous studies regarding the single machine scheduling (SMS) problem. This paper investigates the SMS problem with sequence-dependent setup time (SDST). First, a model of SMS-SDST is developed to minimise the makespan. An earliest due date (EDD), SDST, and ant colony optimisation (ACO) heuristic algorithm is presented. In order to evaluate the performance of the proposed algorithm, Taguchi’s robust design method is employed to define the best parameter values. Related results are analysed by statistical tools. The computational experiments are compared with an ACO algorithm and a genetic algorithm. The experimental results and statistical analyses show that the proposed EDD-SDST-ACO is effective for the problem.
Chemosensitivity and resistance testing in malignant effusions with focus on primary malignant mesothelioma and metastatic adenocarcinoma
Authors: Szulkin Adam , Szatmári Tünde , Hjerpe Anders , Dobra Katalin
Published: September 2016

Cell based chemosensitivity and resistance testing is an attractive approach that offers functional measurement of drug responseex vivowith the ultimate goal to guide the choice of chemotherapy for various cancers. Thus, it has a great potential to select patients for the optimal treatment option, thereby offering a tool for personalized cancer therapy.

Despite several decades of intensive scientific effortsex-vivotests are still not incorporated in the standard of care. Limited access to fresh tumor tissue, unsatisfactory models and single readout as endpoint constitute major hindrance. Thus, establishing and validating clinically useful and reliable model systems still remains a major challenge.

Here we present malignant effusions as valuable sources forex-vivochemosensitivity and resistance testing. Accumulation of a malignant effusion in the pleura, peritoneum or pericardium is often the first diagnostic material for both primary malignant mesothelioma and a broad spectrum of metastatic adenocarcinoma originating from lung-, breast-, ovary- and gastro-intestinal organs as well as lymphoma.

In contrast to biopsies, in these effusions malignant cells are easily accessible and often abundant. Effusion derived cells can occur dissociated or forming three-dimensional papillary structures that authentically recapitulate the biology of the corresponding tumor tissue and offer models forex vivotesting. In addition, effusions have the advantage of being available prior to or concurrent with the pathological review, thus constituting an excellent source of viable cells for simultaneous molecular profiling, biomarker analysis and for establishing primary cells for studying tumor biology and resistance mechanisms.

For a reliable test, however, a careful validation is needed, taking into account the inherited heterogeneity of malignant tumors, but also the complex interplay between malignant and benign cells, which are always present in this setting.
‘Egypt’: legitimation at the museum
Authors: James N.
Published: September 2016

Heracleion and Canopus were towns recorded in Classical sources about the Nile delta. Surveys near Alexandria in 1996 found ruins poking through the sands under four or five fathoms of murky water. Revealing complexes of temples, excavation then confirmed that these were the remains of Heracleion and the eastern part of Canopus, dating from the Late Dynastic era. The discoveries show how Greek traders had settled, and how the towns then thrived, after Alexander the Great's conquest (332 BC), during the Hellenistic or Ptolemaic period. Following a somewhat smaller display in Paris in 2015–2016, many of the finds can now be admired at the British Museum until 27 November 2016 in the exhibition ‘Sunken cities: Egypt's lost worlds’.
Neo-Prehistory—Exist. Regenerate. Repeat?
Authors: Chippindale Christopher
Published: September 2016

As archaeologists we try hard to communicate our insights to a wider public, whether through lucid writing, as exemplified by Brian Fagan's many books, or increasingly through technology such as a 60-second YouTube video. But our subject runs away from us, and our audience, as it gets ever more technical. A century ago, discussion of the chronology of Stonehenge relied on everyday language to describe the order in which the stones were put up; now it depends on Bayesian statistics applied to calibrated radiocarbon dates (Parker Pearson et al.2007). How many practising archaeologists understand that well enough to explain it lucidly in 60 seconds? Or really understand it at all?
New investigations at the Middle Stone Age site of Pockenbank Rockshelter, Namibia
Authors: Schmidt Isabell , Ossendorf Götz , Hensel Elena , Bubenzer Olaf , Eichhorn Barbara , Gessert Lothar , Gwasira Goodman , Henselowsky Felix , Imalwa Emma , Kehl Martin , Rethemeyer Janet , Röpke Astrid , Sealy Judith , Stengel Ingrid , Tusenius Madelon
Published: September 2016

In southern Africa, Middle Stone Age sites with long sequences have been the focus of intense international and interdisciplinary research over the past decade (cf. Wadley 2015). Two techno-complexes of the Middle Stone Age—the Still Bay and Howiesons Poort—have been associated with many technological and behavioural innovations of Homo sapiens. The classic model argues that these two techno-complexes are temporally separated ‘horizons’ with homogenous material culture (Jacobs et al.2008), reflecting demographic pulses and supporting large subcontinental networks. This model was developed on the basis of evidence from southern African sites regarded as centres of subcontinental developments.
In search of mound-builder histories
Authors: Pauketat Timothy R.
Published: September 2016

There are insights to be gained from comparing three very different books on the mounds, mound-builders and moundvilles of later pre-Columbian and early historic-period eastern North America. These insights stem from the range of perspectives embodied by the trio of hardbacks here, written by authors with diverse backgrounds using very different kinds of case material. In one book, historian Terry Barnhart gives us a rich reading of the historical relationship of American archaeology to ‘The Mound Builders’, identified by many Euro-Americans in the late eighteenth and nineteenth centuries as an actual lost race or civilisation that pre-dated the American Indian occupation of the continent. In another book, writer Jay Miller seeks a cosmological explanation of all eastern North American mounds, in some ways reaffirming the centrality of mound building to Native identities. In a third volume, editor-archaeologists C. Margaret Scarry and Vincas Steponaitis, and 12 other authors, present the latest archaeological synthesis on Moundville, a great town in Alabama often cited as the civic-ceremonial core of a stereotypical Mississippian-era chiefdom (c. AD 1120–1650). Tacking between the three texts, we might come to appreciate more clearly how we know, or might know, the mound-builder past by contextualising and theorising that past better than we are currently doing.
SISTEMAS DE VIABILIDADE AGRÍCOLA SUSTENTÁVEIS
Authors: Vale Italo Guimarães , Sanchez Delgado Angel Ramon , Drumond Ventura Sergio
Published: September 2016

SISTEMAS DE VIABILIDADE AGRÍCOLA SUSTENTÁVEIS ITALO GUIMARÃES DO VALE1; ANGEL RAMON SANCHEZ DELGADO2 E SÉRGIO DRUMOND VENTURA3  1 Mestrando do Programa de Pós-Graduação em Modelagem Matemática e Computacional do Departamento de Matemática do Instituto de Ciências Exatas da Universidade Federal Rural do Rio de Janeiro, BR 465, Km 7, Seropédica, RJ, 23890-000.italovale@ufrrj.br2 Professor Associado do Departamento de Matemática do Instituto de Ciências Exatas da Universidade Federal Rural do Rio de Janeiro, BR 465, Km 7, Seropédica, RJ, 23890-000. a.sanchez@ufrrj.br.3 Professor Adjunto do Departamento de Matemática do Instituto de Ciências Exatas da Universidade Federal Rural do Rio de Janeiro, BR 465, Km 7, Seropédica, RJ, 23890-000. ventura@ufrrj.br.  1 RESUMO O seguinte trabalho define um sistema de viabilidade agrícola sustentável (SVAS), através de um conjunto finito de desigualdades lineares e não lineares no espaço dos insumos necessários para o desenvolvimento de culturas agrícolas que tenham produção, receita líquida e recursos limitados inferior e/ou superiormente (sustentabilidade). O problema aqui tratado é determinar se SVAS é não vazio, isto é, se existe um vetor de insumos ou recursos que satisfaz todas as desigualdades no SVAS. Apresentamos uma heurística para resolver o problema e resultados numéricos para SVAS em função da água e nitrogênio, junto a funções de produção em formas quadráticas de algumas culturas conhecidas na literatura. Palavras-chave: Produção, Receita líquida, Insumos, Heurística.  VALE, I.G.; DELGADO, A. R. S. e VENTURA, S.V.VIABILITY SYSTEMS FOR SUSTAINABLE AGRICULTURE  2 ABSTRACT The following work mathematically defines a viability system for sustainable agriculture (VSSA), through a finite set of linear and non-linear inequalities in R^n, representing the space of required inputs for the development of m crops, and where production, net-income and resources (or inputs), have upper and/or  lower bounds (sustainability). The problem addressed here is to determine whether VSSA is not empty, i.e., if there is a vector of inputs or resources satisfying all inequalities in VSSA. We present a heuristic to solve the problem and numerical results for VSSA depending on water and nitrogen, together with production functions in quadratic forms for some cultures, as known in the literature. Keywords: production, net-income, inputs, heuristic