bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATING THE IMPACT OF DENSITY ON ACCESS TO LOCAL FACILITIES IN URBAN NEIGHBOURHOODS
Authors: Wan Mohd Rani Wan Nurul Mardiah
Published: November 2021

Local services and facilities in residential neighbourhoods play an important role towards the social sustainability of local residents. It is believed that having good provision and access to these local services and facilities would contribute significantly to the quality of life and residentsâ€™ well-being. The form of the neighbourhood influences the way people live in the neighbourhood. The way people settle in neighbourhoodâ€™s shapes the quality of life, the richness of the local economy, the level of social cohesion, the level of safety and the amount and the kind of human activities in public spaces. Different urban forms can have very different degrees of sustainability. Density is one of the urban form elements that have been research numerous times and proven to have an influence on the neighbourhood sustainability. Density is the most easily measured urban form element either at a macro level (city) or micro level (neighbourhood). This research discusses the impact of density on the micro scale through estimating its influence on access to local facilities. Through the use of household survey and supported by observation survey, this study findings on the impact of density on access and use of local facilities. The study concludes with establishing the findings of the survey to reflect and fit into the body of knowledge and how it would improve the guidelines and policy on social sustainability in improving the urban living as a whole.
ANALYSIS OF SHRINES PROPERTIES USING REMOTE SENSING APPROACH: CASE STUDY OF LEMBAH BUJANG
Authors: Roslan Shairatul Akma , Mohd Noor Noorzailawati , Abdullah Alias , Md Ali Zuraini
Published: November 2021

The heritage of Lembah Bujang, Kedah is important as a starting point to understand the origins and history of civilization in Malaysia. This research is to analyze the spectral reflectance of shrines properties in an identified area by using remote sensing techniques in conserving this cultural heritage site. The remote sensing device (Spectroradiometer) was used to measure the spectral reflectance of the source of shrines in the study area. This tool was applied for reflectanceâ€™s test over properties such as ancient brick, granite, literates and iron in a different two study areas consist of Lembah Bujang and Kompleks Sungai Batu. Remote sensing test properties demonstrate that discrimination of properties types of each civilization is possible through reflection measurement, but that discrimination is complicated by surface conditions, such as weathering and lichen growth. Comparison between clays, granite and iron show that clays to be more reflective than granite and iron. This result will help more in our further study on detecting these properties direct through remote sensing imagery and will be helpful in developing new indexes and selection of threshold value on shrines material in the case study of Lembah Bujang.
ARCHITECTURAL INFLUENCES OF ISTANA LAMA SERI MENANTI, NEGERI SEMBILAN
Authors: Zainal Abidin Nurdiyana , Raja Shahminan Raja Nafida , Ibrahim Fawazul Khair
Published: November 2021

Traditional Malay Royal Palaces in Malaysia are monumental buildings representing the rich architecture, heritage, traditions and expertise of the Malays. The architecture of these palaces differs from one another to demonstrate the identities of the vernacular architecture as timber palaces were representations of Traditional Malay Houses on an exaggerated scale. One example of this is Istana Lama Seri Menanti in Kuala Pilah which is a four-storey timber palace built in the 20th century by Malay carving experts. Another factor to consider is the rich cultural acceptance of the Minangkabau as they have been around in Negeri Sembilan since the 15th Century. Hence, this paper aims to determine the architectural identity of Istana Lama Seri Menanti through the influences on the palace architecture and the factors affecting these influences. The research methods undertaken include case studies, interviews with experts, and document and historical analysis of subjects about palaces. The findings conclude that the key element of â€˜atap bergonjongâ€™ cannot be found in Istana Lama Seri Menanti which has the more common modest curve of the roof ridges found in houses of Negeri Sembilan. Furthermore, Chinese influences on the woodcarvings of the palace can be seen on the columns and beams of the exterior of the palace. In conclusion, there are many influences on the architectural identity of Istana Lama Seri Menanti such as Chinese influences and Britishâ€™s political influences on the design of the palace.
MODELLING WILLINGNESS TO PAY FOR IMPROVED PUBLIC TRANSPORT SERVICES: THE CHALLENGES OF NON-RESPONSE TO STATED PREFERENCE HYPOTHETICAL QUESTIONS
Authors: Bachok Syahriah , Ponrahono Zakiah
Published: November 2021

The paper focuses on the modelling attempt of willingness to pay for an improved bus service in selected cities and towns of Malaysia. Using responses from onboard intercept surveys, 1,130 samples of bus passengers have been analysed so as to arrive at a simplified model of how passengers trade off their money with possible upgrading of bus services elements. The willingness to pay among these bus riders was very low, despite the high expectation of improvements aspired by them. For service providers, fares are a function of travel time, travel distance and other operating costs. For passengers, the utility function is explained by costs, time, distance and various latent parameters. This paper highlights the significant results of chi-square analysis at various confidence levels. However, modelling the exact utility function of preferences for staggered increased in fares could not be carried out successfully at 95 percent confidence level, due to the relatively small number of respondents stating their and/or undecided response towillingness to pay for the additional fare rate. The issue of non-response to hypothetical survey questions is also raised, explaining the difficulties in modelling this choice behaviour.
Rural Sustainability : An Examination Of The Practice of Sustainable Development Principles in a Rural Community in Malaysia
Authors: Ngah Ibrahim
Published: November 2021

This paper examines the extent to which sustainable development principles are practiced in rural life in Malaysia. The first part of the paper defines the concept and principles of rural sustainability. The second part highlights the findings of a case study on rural sustainability practice of a rural community in Malaysia. These include the practice of recycling and reuse of materials, utilization of electricity, water and chemical substances, mode of transport, diversification of economic activities and social cohesion. The study indicates that the level of awareness and the practice of sustainability principles are still low among rural people. Few measures are suggested to promote greater awareness and the practice of rural sustainability in rural areas.
MANAGING URBAN DEVELOPMENT PROCESS BY USING SPATIAL INFORMATION SYSTEM: A Case Study of I-Space
Authors: Abdullah Alias , Abdullah Muhammad Faris , Nordin Fauzan
Published: November 2021

The advancement in Information and Communication Technology (!CT), particularly in relation to Geographical Information System (GIS), Computer Aided Design (CAD), Database Management System (DBMS), and Facility Management System (FMS), has provided the opportunity for urban government to adopt innovative and effective technologies to aid and improve the management and decision-making in urban development process. Among the obstacles that hamper effective management and decision-making in urban development process are the absence of integration between the works of the professionals involve in such process and the unavailability of immediate and reliable data to form the basis for sound decision-making. Thus, this paper proposes that a city-wide spatial information system to be developed comprising two major elements: a common platform for integrating the works of the various built environment professionals and a city-wide built environment database. While the common platform will help to streamline the works of the professionals, the database will assists urban government in making sound and informed decision in relation to planning, management, maintenance, and monitoring of the urban built environment. This paper highlights the efforts of the International Islamic University Malaysia (IIUM) in developing its spatial information system. The system is designed to provide information on the IIUM property that covers buildings, infrastructure, facilities, and space to decision makers and managers to help them in making sound decision and in implementing effective property management scheme.
CONSERVATION WITH DEVELOPMENT: SHOWCASING LANGKAWI GEOPARK
Authors: Hashim Halimaton Saadiah , Aziz Sarah , Abdul Aziz Rahimah
Published: November 2021

Debates on whether conservation and development can be integrated have been going on for decades. Economists argue that the economy is the main support of the human race; conservationists argue that without sustainable natural and human resources, economic activities cannot be sustained; humanists argue that culture and history are necessary to sustain a communityâ€™s identity and continued existence. This article argues that conservation and development can be integrated through sustainable development. Land use planning is identified as the integrating process while sustainable land use development is the manifestation of integrated conservation and development. The geopark concept, developed by the Global Geopark Network (GGN), and endorsed by the United Nations Economic and Cultural Organisation (UNESCO), which promotes conservation, education and sustainable development, is accepted as a concept which conserves natural and cultural heritage while enhancing socio-economic development for the sustainable wellbeing of the local population. Langkawi Geopark is an example of such integration.
ELECTRONIC LOCAL AUTHORITY MANAGEMENT SYSTEM
Authors: Thean Siew Tan
Published: November 2021

One of the most important functions of a local authority in Malaysia is development control under the Town and Country Planning Act, 1976 (Act 172) and the Street, Drainage and Building Act, 1974 (Act 133). With the powers under these acts, the local authority is responsible to ensure that any activity of development is carried out in an orderly manner so as not to cause immediate as well as long-term undesirable impacts on the neighbours, the surroundings and the environment. To do this the law requires that any person intending to carry out any development will need a planning permission and a building plan approval from the local authority. In giving such an approval the local authority has to check and ensure that the developer can and will carry out the development properly and according to a good set of by-laws, standards, regulations and guidelines drawn up to protect the safety, health and amenity of the people in the local authority area. However most local authorities, due to numerous valid reasons, have problems carrying out this task and are often accused of causing delays to the development process and hence to the economic progress of the country. Often, justly or unjustly, local authority officers and decision-makers have been branded as not transparent and corrupt for taking such a confusing and lengthy process in considering applications for development approval. Local authorities have hence an almost impossible task of protecting the environment and ensuring sustainable development and at the same time promoting further development and timely economic growth. In an attempt to overcome this problem the Municipal Council of Penang Island (MCPJ), with grants from the Development Application Grant Scheme (DAGS) of the National IT Council (NITC) of Malaysia, embarked on a project to develop an Electronic Local Authority Management System, or "eLAMS". This will assist in the day-to-day functions of processing and considering of applications for planning permission, building plans and earthworks plans, in accordance with a good quality management and environmental managen1ent system. This paper examines the problems of the development control process for sustainable development and the problems of adopting and adapting the electronic system faced by local authorities in Malaysia in general and the Municipal Council of Penang Island in particular. This paper will also outline the proposals to overcome these problems with eLAMS.
A STUDY ON THE DEMAND OF SPATIAL PLANNING AND DECISION SUPPORT SYSTEM IN MALAYSIA
Authors: Abdullah Muhammad Faris , Abdullah Alias , Ibrahim Mansor , Abdul Samad Dazilah
Published: November 2021

This paper examines the demand and interest for SPDSS (Spatial Planning and Decision Support System) among town planners in Malaysia. A survey was conducted among town planners registered with the Malaysian Institute of Planners (MIP) and among local planning authorities. Based on the survey and analysis, it was revealed that many town planners in Malaysia are still unfamiliar with SPDSS, particularly the concept and its applications. Nevertheless, they have expressed interest to know more about SPDSS as well as to include SPDSS in their professional works.
HOW WE FAILED TO PLAN FOR HABITABILITY
Authors: Lik Meng Lee , Abdullah Aldrin , Sook Fern Tan , Badarulzaman Nurwati , Hassan Ahmad Sanusi
Published: November 2021

A quality housing development should not only take into account the physical aspects of design but also be sensitive to human needs. Habitability in housing involves several components, including environmental factors, man-made designs, socio-cultural operations and psychological impacts. Elements of habitability can be observed in various concepts of residential developments including classical concepts such as the Garden City Movement and the Neighbourhood Unit. In Malaysia, the Malay Kampung and the Chinese New Village exemplify some ideal living practices relating to habitability. Both the classical and traditional concepts influenced subsequent residential developments in Malaysia such as the Jengka Project, Kampung Tersusun, Town 8, Cyberjaya and Putrajaya. However, not all residential developments succeeded in creating a quality living environment. More recent concepts such as the New Urbanism and the China Healthy Residence have placed greater emphasis in dealing with such issues. In Malaysia, legislations and policies have not adequately addressed the problems on habitability. We lack a thorough planning system, which prepares and monitors the quality of our residential development. Failures in planning policies have also created other planning issues that affect habitability, as portrayed in the case of the Rifle Range Low-cost Flats in Penang. The top-down approach in housing policy andplanning should be geared up to match the growth of community towards achieving habitability.
A PRELIMINARY INVESTIGATION OF A MODEL ON THE DECISION TO IMPLEMENT TELEWORKING IN THE JAPANESE BUSINESS ORGANIZATIONS
Authors: Kadar Hamsa Abdul Azeez , Miura Masao
Published: November 2021

Teleworking, an alternative form of work arrangement, has gained very little significance in the present information era, as otherwise expected, in modem Japan. Existence of many factors would be directly responsible for the slow growth of teleworking in Japan. This paper highlights few significant factors responsible for the decision to accept teleworking as an alternate work arrangement as expressed by the managers of different business organizations in the Greater Tokyo Metropolitan Area (GTMA). These factors include but not limited to: organizational values, advantages of teleworking, performance evaluation, strategically measures and information technology requirements. A logistic regression model was developed to test the significance of these factors against the decision to implement teleworking. Finally, conclusions were also drawn.
BOOK REVIEW : THE BOULEVARD BOOK. Boston: M.I.T. Press
Authors: Charng Yen Shu
Published: November 2021

In the course of our master planning work for new communities, many times we might have tried to come up with new ideas forgetting how invaluable our current urban form which has evolved through the times. Places we are familiar with, our "Jalan Besar", "Jalan Bandar", our "Padang", "Bulatan ", "Pesiaran ", "Medan Pasar ", etc. which offers priceless lessons which can be applied to our new environments.Perhaps we are trying to stamp our personal identity into the new places which is within our sphere of influence, as planners, to create, especially with modem technology, we can create something out of nothing. For example, cutting an expressway is by blasting through a steep terrain. Of course, not all is bad, some good things can come out of new technology, converting ex-mining land into resorts that appeal and are used by many.
URBAN SPRAWL IN MALAYSIA: EVIDENCES FROM THREE LARGEST METROPOLITAN AREAS
Authors: Abdullah Jamalunlaili , Yahaya Mohd. Zulhafidz , Yunus Mohd Zuwairi , Md Ali Safudin Mohd Shakir
Published: November 2021

Urban sprawl is a one of the most pressing issues confronting urban development in the developed as well as developing countries. Much research had been done on the trend of urban sprawl and its negative consequences in established cities in the United States, Europe and Australia. This paper analyzes the phenomenon in the three largest metropolitan areas in Malaysia, namely Kuala Lumpur, Penang and Johor Bharu Metropolitan Areas. Using population and land use as main variables, it argues that suburban expansion and the resulting urban sprawl has been occurring in these metropolitan areas since 1970 and has intensified since the late 1980s due to the rapid economic growth brought by industrialization. It calls for more sustainable approach in the planning and management of urban areas in Malaysia.
URBAN RESIDENTS' ATTITUDES TOWARD WILDLIFE IN THEIR NEIGHBOURHOODS: THE CASE STUDY OF KLANG VALLEY, MALAYSIA
Authors: Nik Mohamad Nik Hanita
Published: November 2021

Rapid urbanisation in Malaysia has resulted in the loss and fragmentation of lowland tropical forests. Due to the modification ofhabitat needs provided by these natural green, the diversity and population of urban wildlife have been significantly reduced. Urban parks provided are recognized as an effective urban conservation strategy to mitigate the effects of urbanisation by conserving, enhancing and creating new habitats for urban wildlife. Potential of neighbourhood green spaces to function as urban wildlife habitats has not been optimized. This research investigates urban residents' responses to different dimension of attitudes toward common wildlife; and their needs for wildlife in the contact of sustainable living in the Klang Valley. The research, has sought to investigate through a combination of surveys and observations on residents' attitudes toward urbanwildlife. The findings demonstrated selective preferences towards urban wildlife while residents displayed strong preferences toward naturalistic landscape elements compared to man-made landscape elements.
Detecting Tonic-Clonic Seizures in Multimodal Biosignal Data From Wearables: Methodology Design and Validation (Preprint)
Authors: Böttcher Sebastian , Bruno Elisa , Manyakov Nikolay V , Epitashvili Nino , Claes Kasper , Glasstetter Martin , Thorpe Sarah , Lees Simon , Dümpelmann Matthias , Van Laerhoven Kristof , Richardson Mark P , Schulze-Bonhage Andreas , The RADAR-CNS Consortium Phil
Published: November 2021

BACKGROUND

Video electroencephalography recordings, routinely used in epilepsy monitoring units, are the gold standard for monitoring epileptic seizures. However, monitoring is also needed in the day-to-day lives of people with epilepsy, where video electroencephalography is not feasible. Wearables could fill this gap by providing patients with an accurate log of their seizures.

OBJECTIVE

Although there are already systems available that provide promising results for the detection of tonic-clonic seizures (TCSs), research in this area is often limited to detection from 1 biosignal modality or only during the night when the patient is in bed. The aim of this study is to provide evidence that supervised machine learning can detect TCSs from multimodal data in a new data set during daytime and nighttime.

METHODS

An extensive data set of biosignals from a multimodal watch worn by people with epilepsy was recorded during their stay in the epilepsy monitoring unit at 2 European clinical sites. From a larger data set of 243 enrolled participants, those who had data recorded during TCSs were selected, amounting to 10 participants with 21 TCSs. Accelerometry and electrodermal activity recorded by the wearable device were used for analysis, and seizure manifestation was annotated in detail by clinical experts. Ten accelerometry and 3 electrodermal activity features were calculated for sliding windows of variable size across the data. A gradient tree boosting algorithm was used for seizure detection, and the optimal parameter combination was determined in a leave-one-participant-out cross-validation on a training set of 10 seizures from 8 participants. The model was then evaluated on an out-of-sample test set of 11 seizures from the remaining 2 participants. To assess specificity, we additionally analyzed data from up to 29 participants without TCSs during the model evaluation.

RESULTS

In the leave-one-participant-out cross-validation, the model optimized for sensitivity could detect all 10 seizures with a false alarm rate of 0.46 per day in 17.3 days of data. In a test set of 11 out-of-sample TCSs, amounting to 8.3 days of data, the model could detect 10 seizures and produced no false positives. Increasing the test set to include data from 28 more participants without additional TCSs resulted in a false alarm rate of 0.19 per day in 78 days of wearable data.

CONCLUSIONS

We show that a gradient tree boosting machine can robustly detect TCSs from multimodal wearable data in an original data set and that even with very limited training data, supervised machine learning can achieve a high sensitivity and low false-positive rate. This methodology may offer a promising way to approach wearable-based nonconvulsive seizure detection.
Momentary Manifestations of Negative Symptoms as Predictors of Clinical Outcomes in People at High Risk for Psychosis: Experience Sampling Study (Preprint)
Authors: Paetzold Isabell , Hermans Karlijn S F M , Schick Anita , Nelson Barnaby , Velthorst Eva , Schirmbeck Frederike ,   EU-GEI High Risk Study, van Os Jim , Morgan Craig , van der Gaag Mark , de Haan Lieuwe , Valmaggia Lucia , McGuire Philip , Kempton Matthew , Myin-Germeys Inez , Reininghaus Ulrich
Published: November 2021

BACKGROUND

Negative symptoms occur in individuals at ultrahigh risk (UHR) for psychosis. Although there is evidence that observer ratings of negative symptoms are associated with level of functioning, the predictive value of subjective experience in daily life for individuals at UHR has not been studied yet.

OBJECTIVE

This study therefore aims to investigate the predictive value of momentary manifestations of negative symptoms for clinical outcomes in individuals at UHR.

METHODS

Experience sampling methodology was used to measure momentary manifestations of negative symptoms (blunted affective experience, lack of social drive, anhedonia, and social anhedonia) in the daily lives of 79 individuals at UHR. Clinical outcomes (level of functioning, illness severity, UHR status, and transition status) were assessed at baseline and at 1- and 2-year follow-ups.

RESULTS

Lack of social drive, operationalized as greater experienced pleasantness of being alone, was associated with poorer functioning at the 2-year follow-up (b=−4.62, P=.01). Higher levels of anhedonia were associated with poorer functioning at the 1-year follow-up (b=5.61, P=.02). Higher levels of social anhedonia were associated with poorer functioning (eg, disability subscale: b=6.36, P=.006) and greater illness severity (b=−0.38, P=.045) at the 1-year follow-up. In exploratory analyses, there was evidence that individuals with greater variability of positive affect (used as a measure of blunted affective experience) experienced a shorter time to remission from UHR status at follow-up (hazard ratio=4.93, P=.005).

CONCLUSIONS

Targeting negative symptoms in individuals at UHR may help to predict clinical outcomes and may be a promising target for interventions in the early stages of psychosis.
Vitiligo and Metabolic Syndrome: Systematic Review and Meta-Analysis (Preprint)
Authors: Xia Joyce , Melian Christina , Guo William , Usmani Hunya , Clark Richard , Lozeau Daniel
Published: November 2021

BACKGROUND

Metabolic syndrome (MetS) has been associated with various skin conditions including vitiligo. However, the association between these 2 conditions has yet to be determined by quantitative meta-analysis.

OBJECTIVE

The aim of this paper was to determine the association between vitiligo and metabolic syndrome via systematic review and meta-analysis.

METHODS

A systematic literature search of Pubmed, Embase, Cochrane, and Web of Science was performed for all published literature prior to August 16, 2020. Case control and prospective cross-sectional studies analyzing the association between vitiligo and MetS were included in this review. The primary outcome measures include the type of vitiligo, diagnostic criteria for MetS, components of MetS (waist circumference, blood pressure, triglycerides, fasting glycemic index, and high-density lipoprotein cholesterol), low-density lipoprotein cholesterol levels, and BMI. A meta-analysis was performed to evaluate the prevalence and association of MetS in patients with vitiligo.

RESULTS

A total of 6 studies (n=734 participants) meeting eligibility criteria were included for systematic review and meta-analysis. The pooled prevalence of MetS in patients with vitiligo was (0.296, 95% CI 0.206, 0.386; P<.001). Patients with vitiligo were no more likely to develop MetS compared to control patients (odds ratio 1.66, 95% CI 0.83, 3.33; P=.01). A leave-one-out sensitivity analysis showed a significant association between MetS and vitiligo (P<.001). Significant elevations in fasting glycemic index (mean difference 5.35, 95% CI 2.77, 7.93; P<.001) and diastolic blood pressure (mean difference 1.97, 95% CI 0.02, 3.92; P=.05) were observed in patients with vitiligo compared to control patients.

CONCLUSIONS

The association between vitiligo and metabolic syndrome carries important clinical implications. Dermatologists and other multidisciplinary team members should remain vigilant when treating this patient population in order to prevent serious cardiovascular complications that may arise as a result of metabolic disease.
The Generative Dissensus of Reading the Feminist Novel, 1995-2020: A Computational Analysis of Interpretive Communities
Authors: Mendelman Lisa , Mukamal Anna
Published: November 2021

This article furthers ongoing work on the merits of the feminist novel’s intrinsic variability by probing its dynamics in four publishing contexts: contemporary anglophone literary criticism, prestigious review publications, marketing materials, and online book reviews by social readers. We explore how these interpretive communities converge and diverge in their assessments of feminist fiction over the past twenty-five years by evaluating articles from the MLA International Bibliography, book reviews in The New York Times, The New Yorker, Times Literary Supp-lement, and other prominent periodicals, blurbs from Amazon, and Goodreads reviews. We trace the feminist novel’s ambivalent fates—or rather, feminist novels’ ambivalent fates—in and across these four domains. To do so, we engage computational methods of topic modeling, most distinctive word analysis, and named entity recognition. We synthesize these quantitative results with qualitative attention to provocative examples from our corpus. In so doing, we consider how literary scholars can develop more robust understandings of what feminism and feminist fiction mean to contemporary readers and what we stand to gain by bringing this diverse interpretive labor into our scholarly conversations.
Income Taxes: Objective Values or Subjective Values as They Result from Financial Statements that Contain Subjective Data or Values Determined Subjectively by Financial Reporting Preparers?
Authors: Avi Maria Silvia
Published: November 2021

Research on more than 1500 Italian companies from 2016 to 2019 shows that the inclusion of tax values in financial reporting without any economic content is a widespread accounting practice. Tax interferences in financial reporting have various motivations and prove consequences both inside and outside the company. In the following pages, we will illustrate the results of the analysis carried out, the motivations leading to the incorrect accounting behaviour of the implementation of tax interferences and the consequences resulting from this widespread practice. It should be noted that tax interference causes problems both inside and outside the company. Such tax contamination of financial reporting affects the rights of third parties outside the company, and creates the conditions for challenges to financial reporting due to invalidity of the document. It also creates a basis for incorrect accounting data that can lead to wrong decisions by management.
Cost Benefit of Poultry Farming in Kashmir Valley: Case Study in Anantnag District
Authors: Nisar Junaid , Kumar Dr. Avneesh
Published: November 2021

Poultry farming from last decade earn a good name in terms of income and employment generation in Kashmir valley. Taking this point as our concern we go through the cost benefit of poultry farming in Kashmir valley. As our study area is district Anantnag and we take one medium size poultry farm as our sample. The study shows that the income from poultry farming is so reasonable and normal profits are earned with less effort. So government should have to think about this industry and support them financially and give them new information’s and training regarding poultry farming through which the production and productivity increase. .
“FORMULATION DEVELOPMENT AND SOLUBILITY ENHANCEMENT OF ROSUVASTATIN CALCIUM BY USING HYDROPHILIC POLYMERS AND SOLID DISPERSION METHOD”
Authors: KAUR LOVEPREET , KAUR TARANJIT , SINGH AMAR PAL , SINGH AJEET PAL
Published: November 2021

Objective: Preparation of Rosuvastatin Calcium by Using Hydrophilic Polymers and Solid Dispersion Method, Rosuvastatin calcium is a Dyslipidaemic agent, which act as a selective competitive inhibitor of HMG CoA educates enzyme and is used in the treatment of hyperlipidemia.

Methods: In the present work, Solid Dispersion was prepared by kneading method to increase the solubility of Rosuvastatin Calcium.

Results: Solid dispersions were evaluated by determining percentage yield, drug content, solubility, Scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), DSC and in vitro dissolution profile. The prepared solid dispersion are formulated into capsule dosage form and characterized by various parameters i.e. weight variation, content uniformity, disintegration and dissolution. The evaluated parameters of capsule dosage form increase in solubility and dissolution rate of the pure drug.

Conclusion: These are various techniques to enhance the solubility of the drug, such as particle size reduction, use of surfactants, solid dispersion etc. Carriers are the major players in these formulations, e. g. Hydroxypropylmethylcellulose, ethylcellulose, Carbopol, Acacia Gum etc. Carbopol and Acacia Gum is one of the most efficient polymers work as a carrier for these drugs to enhance solubility.
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR KNOWN AND UNKNOWN IMPURITIES PROFILING FOR CARVEDILOL PHARMACEUTICAL DOSAGE FORM (TABLETS)
Authors: MAHAJAN NITIN , DESHMUKH SUPARNA , FAROOQUI MAZAHAR
Published: November 2021

Objective: The aim of the research work to develop a simple, sensitive, rugged, robust and specific novel gradient stability indicating reverse phase HPLC method for quantitative determination of known and unknown impurities profiling of Carvedilol pharmaceutical dosage forms (Tablets).

Methods: Chromatographic separation has been achieved on an Inertsil ODS 3V column (150 mm x 4.6 mm, 5μm) with mobile phase consisting Mobile phase-A (Water, Acetonitrile and Trifluroacetic acid in the ratio of 80:20:0.1 v/v/v respectively and pH adjusted to 2.0 with dilute potassium hydroxide solution) and Mobile phase-B (Water and acetonitrile in the ratio of 100:900 v/v respectively) delivered at flow rate of 1.0 ml min-1 and the detection wavelength 240 nm. The column compartment temperature maintained at 40 °C.

Results: Resolution between Carvedilol and its impurities has been achieved greater than 1.5. The developed method was validated as per ICH guidelines. Analytical method found Precise, Linear, accurate, specific, rugged and robust.

Conclusion: Developed and validated novel analytical method can be used to for impurity profile analysis of Carvedilol Pharmaceutical dosage form (Tablets).
PRONIOSOMES: A VESICULAR DRUG DELIVERY SYSTEM
Authors: M. SARITHA , PANDA SATYA PRAKASH , BUDDHA SRAVANI , KUMARI P. V. KAMALA , RAO Y. SRINIVASA
Published: November 2021

In the development of new dosage forms, drug delivery using nanotechnology is playing a vital role. Vesicular drug delivery systems have gained wide attention in the field of nanotechnology, such as niosomes, liposomes and proniosomes. Among the vesicular carriers, proniosomes are superior. Proniosomes are water-soluble carrier particles that are coated with surfactant so these are dry formulations. They are rehydrated to use on agitation in hot aqueous media within minutes to form niosomal dispersion immediately. Both hydrophilic and lipophilic drugscan be incorporated into these proteasomes. The physical stability problems of niosomes like aggregation, fusion and leaking are minimized in proniosomes, routes, such as oral, parenteral, dermal and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. Proniosomes prolong the existence of the drug in the systemic circulation and finally reduces toxicity. This review focuses on different aspects of proniosomes such as preparation, characterization, in vitro drug release, entrapment efficiency, applications in the present scenario in the market and future trends.
"FORMULATION AND EVALUATION OF MORONIC ACID LOADED TRANSDERMAL PATCHES"
Authors: RANI RITU , KAUR TARANJIT , SINGH AJEET PAL , SINGH AMAR PAL
Published: November 2021

Objective: To prepare Transdermal patches of Moronic acid along with various polymers for controlled release action.

Methods: Suitable method such as Solvent Casting Technique of Film Casting Technique are used for the preparation of Transdermal patch.

Results: The prepared Transdermal patches were transparent, smooth, uniform and flexible. The method adopted for the preparation of the system was found satisfactory.

Conclusion: Various formulations were developed by using hydrophilic and hydrophobic polymers like HPMC E5 and EC respectively in single and combinations by solvent evaporation technique with the incorporation of penetration enhancer such as dimethylsulfoxide and dibutyl phthalate as plasticizer. Formulation F7 containing an equal ratio of HPMC E5: EC (5:5) showed maximum and sustained release of 86.814±0.262 within 24 h. Kinetic models were used to confirm the release mechanism of the formulations. Moronic acid release from the patches F1 to F7 followed non Fickian diffusion rate controlled mechanism.
РЕАЛИЗАЦИЯ СИНТЕЗА САМОСИНХРОННЫХ СХЕМ В БАЗИСЕ БМК
Authors: Плеханов Л.П. , Денисов А.Н. , Дьяченко Ю.Г. , Мамонов Д.И. , Морозов Н.В. , Степченков Д.Ю.
Published: November 2021

Доклад посвящен реализации автоматизированного синтеза самосинхронных (CC) схем на основе описания схемы на языке Verilog и библиотеки стандартных элементов 5503СС, расширенной специфичными для СС-схем элементами. Программа синтеза имеет графический интерфейс и интегрируется в САПР полузаказных БИС «Ковчег» (МИЭТ).
ПРИЕМНЫЙ ТРАКТ МИЛЛИМЕТРОВОГО ДИАПАЗОНА С ПОДАВЛЕНИЕМ ЗЕРКАЛЬНОГО КАНАЛА
Authors: Редька Ан.В. , Манненбаев В.М. , Краснов В.В.
Published: November 2021

В работе представлены результаты модернизации малошумящего усилителя миллиметрового диапазона частот, предназначенного для работы в системах радиоастрономического наблюдения, функционирующих при низких температурах среды (от 20 К).
USING MIXOGRAPH PARAMETERS AND SOME QUALITY PROPERTIES IN SELECTION OF DURUM WHEAT GENOTYPES
Authors: Aydogan Seydi , Akcacik Aysun Gocmen
Published: November 2021

This research was carried out in order to determine some chemical, physical and rheological (mixograph) traits of 4 standard durum wheat varieties and 11 durum wheat lines in 2015-2016 under irrigated conditions in Gözlü and Central location of Konya according to randomized block design with three replications. Means of quality parameters varied for thousand kernel weight (30.26-38.45 g), protein ratio (12.94-14.77%), SDS sedimentation (13.75-29.75 ml), color (b value) (20.45-23.35), mixograph development time (1.55-3.79 min), peak height (46.47-81.38%), softening (slope) (6.46-28.85 min/%), peak width (2.19-15.13%), peak area (54-165 Nm) and total area (energy) (236-407 Nm). Significant differences were found between wheat varieties in terms of examined features. Durum wheat lines having weak, strong and very strong gluten were identified in this research. Keywords: Wheat breeding, landraces, genetic structure, semolina, dough traits, gluten index, mixograph parameters.
COMPARATIVE TOXICITY OF SOME INSECTICIDES AGAINST RICE LEAF FOLDER (Cnaphalorosis medinalis) UNDER FIELD SITUATIONS
Authors: Ahmed Masood , Shahbaz Muhammad
Published: November 2021

against Cnaphalorosis medinalis. Four synthetic insecticides were applied with three replicates at recommended dose rates. Toxicity trials were performed under RCBD. The results of the toxicity experiments disclosed the lowest mean leaf reduction damage (6.84%) after 14 days of 2nd spray by application of Flubendamide followed by Emmamectin Benzoate (15.03%). The damage was reduced 17.21-17.00% in case of Fibronil and 17.19-16.12% by Lambda cyhalothrin but was superior to untreated plots. The results of 1st spray revealed that the lowest mean leaf damage (12.24%) was noted in case of Flubendamide application among the tested insecticides. In case of yield analysis, the highest percent grain filling (92.34%) was examined in Belt insecticide trailed by Timer (87.12%), whereas the lowest (70.46%) was noted in case of control. Increase in yield (%) disclosed that the highest increase in yield (21.54%) was recorded in application of Belt insecticide, while relatively the lowest (10.23%) was observed in Boxer insecticide. Overall, the results depicted that the longest exposure period proved more effective as relative high reduction in leaf damage, and Flubendamide was the most effective among the all tested insecticides. Hence, this insecticide can be used in Intergrated Pest Management Program (IPM) for the successful management of C. medinalis. Keywords: Oryza sativa, insect pests, IPM, pest scouting, toxicity bioassays, efficacy.
A Review Article on Brain Tumor Detection and Optimization using Hybrid Classification Algorithm
Authors: Yadav Nitesh
Published: November 2021

Abstract: This review focuses on different imaging techniques such as MRI. This survey identifies a different approach with better accuracy for tumor detection. This further includes the image processing method. In most applications, machine learning shows better performance than manual segmentation of the brain tumors from MRI images as it is a difficult and timeconsuming task. For fast and better computational results, radiology used a different approach with MRI, CT-scan, X-ray, and PET. Furthermore, summarizing the literature, this paper also provides a critical evaluation of the surveyed literature which reveals new facets of research. Keywords: Brain tumor, data mining techniques, filtering techniques, MRI, classifiers, feature selection.
Legal Basis of Life Safety
Authors: Yoqutxon Yoqubjanova
Published: November 2021

Annotation: In order to systematize the teaching materials on the subject, students and teachers have the opportunity to gain an understanding of the basics of organization, industrial sanitation, electrical safety, fire safety, first aid in order to systematize the teaching materials on the subject. Keywords: technologies in industry, life safety, modern requirements.
Effects of message framing and consumers' regulatory focus on perceived credibility of electronic word-of-mouth and purchase intention
Authors: Hsu Tzu-Fan , Yang Chao-Ming
Published: November 2021

We adopted a two-way analysis of variance to evaluate the effect of positive and negative message framing and consumers' regulatory focus (promotion- and prevention-focused) on the perceived credibility of electronic word-of-mouth (eWOM) and purchase intention. Participants were 344
adults in Taiwan aged between 20 and 60 years. Results show that (a) prevention-focused (vs. promotion-focused) consumers perceived eWOM had greater credibility when they were presented with a negatively framed message, (b) negative (vs. positive) message framing increased the perceived credibility
of eWOM for prevention-focused consumers, (c) promotion-focused (vs. preventionfocused) consumers had a stronger purchase intention when presented with a positively framed message, and (d) both prevention- and promotion-focused consumers had stronger purchase intention when exposed to a positively
(vs. negatively) framed message. Our findings may provide a reference for companies to establish a set of eWOM marketing strategies.
Firm-level digital transformation affects individual-level innovative behavior: Evidence from manufacturing firms in China
Authors: Zhao Xiaomin , Liu Yunqing , Xie Yu , Fan Jianchang
Published: November 2021

Digital technologies significantly impact on manufacturing firms as they innovate their business processes in response to rapidly changing environments. Therefore, the proper use of digital technology to promote innovative behavior has become an important topic in research. However, few studies have examined how firm-level digital transformation affects individual-level innovative behavior. Drawing on the minority dissent perspective, we explored the mechanism by which digital transformation affects innovative behavior. Surveying 540 participants from Chinese manufacturing firms revealed that firm-level digital transformation was significantly correlated with both crossfunctional minority dissent and individual-level innovative behavior. Moreover, minority dissent played a partial mediating role in the relationship between digital transformation and innovative behavior. This study sheds new light on how firm-level digital transformation can determine individual-level innovative behavior.
Effect of corporate social responsibility perception on job satisfaction
Authors: Ko Sung-Hoon , Lee Sae Hoon , Kim Ji-Young , Choi Yongjun , Kim Jongsung , Kang Hyun Chul
Published: November 2021

This study empirically examined the effect of the perception of corporate social responsibility (CSR) activities on job satisfaction, as mediated by compassion and positive emotions toward work. Data were collected from 232 employees working in manufacturing, financial, telecommunications, transportation, and service industries in South Korea. The results confirm that (a) there were positive relationships between the perception of CSR activities and compassion, and between compassion and job satisfaction; (b) there were positive relationships between positive emotions toward work and job satisfaction, and between the perception of CSR activities and job satisfaction; and (c) there was a serial multiple mediation effect of compassion and positive emotions toward work on the pathway from the perception of CSR activities to job satisfaction. Theoretical and practical implications are discussed.
Dark Triad but a bright future? Socially malevolent personality traits and proactive career behavior
Authors: Cui Zilong , Zhang Kaixin
Published: November 2021

We explored the effect of the toxic characteristics of the Dark Triad of personality traits, comprising narcissism, Machiavellianism, and psychopathy, on proactive career behavior, and the role of career adaptability as a mediator. We used two-wave lagged data from a survey conducted with 449 Master of Business Administration university students in China. Machiavellianism and narcissism were both positively related to proactive career behavior and career adaptability, but psychopathy was not positively related to either. Further, the effects of Machiavellianism and narcissism on proactive career behavior were mediated by career adaptability. Our results show that narcissism and Machiavellianism play a positive role in explaining important career-related behavior. Theoretical implications and directions for future research are discussed.
SPECIFIC FEATURES OF PUBLIC HEARING IN THE POST-COVID SPACE AS A FORM OF INTERACTION OF CIVIL SOCIETY WITH THE STATE
Authors:   Perm State University, Mkhitaryan L.Yu.
Published: November 2021

Regulatory legal acts of the federal, regional and municipal levels, which regulate the concept and the procedure for holding public hearings are analyzed. Proposals to make the results of public hearings imperative, as well as the need to involve specialists in matters requiring special knowledge at the stages of preparation and holding of public hearings are formulated.
DUAL-POWER CONFLICT IN RUSSIA IN YEAR 1993 STRUCTURE
Authors:   Lomonosov Moscow State University, Ponyaev I.M.
Published: November 2021

Political crisis of dual power in Russia in the early 1990s from the origins to the end is examined. The essence of the confrontation between the parties is revealed. The conflict is considered as a single political event that consists of several stages forming certain structure.
Analisis Timbulan Dan Komposisi Sampah Untuk Potensi Reduksi Sampah Di Kelurahan Selamat
Authors: Widyawati Widyawati , Hutagalung Winny Laura C.
Published: November 2021

Timbulan sampah akan meningkat seiring dengan pertambahan jumlah penduduk, sedangkan komposisi sampah mengalami perubahan setiap tahun akibat adanya perubahan pada pola hidup dan tingkat ekonomi masyarakat. Berbagai komponen sampah menyimpan potensi untuk dapat dimanfaatkan kembali atau diolah untuk menghasilkan produk baru non energi melalui proses recovery dan recycling. Hasil penelitian menunjukkan,, timbulan sampah yang dihasilkan di Kelurahan Selamat dalam satuan berat adalah 108,71 kg/hari atau dalam satuan volume 1,1186 m3/hari. Komposisi sampah yang dihasilkan di Kelurahan Selamat terdiri dari, 65,57% sampah organik dan sampah anorganik 34,43 % yang terdiri dari 12,55% sampah kertas, 0,13% sampah karet, 1,78% sampah tekstil, 17,08% sampah plastik, 0,56% sampah kaca, 0,48% sampah logam dan 1,85% lain-lain. Potensi reduksi sampah di Kelurahan Selamat sebesar 56,16 kg/hari atau 51,66% dari total sampah. Potensi reduksi sampah berdasarkan komposisi jenis sampah dengan pengomposan 37,33% dan daur ulang 14,33%. Kesediaan masyarakat untuk mengolah sampah sendiri masih sangat rendah, ini disebabkan peran masyarakat untuk pengolahan sampah tidak sesuai. Pengelolaan yang dilakukan masyarakat hanya sebatas mengumpulkan sampah organik dan anorganik. Umumnya sampah dikumpulkan dan diangkut oleh petugas bahkan ada yang membakar secara langsung ditepi jalan atau perkarangan rumah disekitaran tempat tinggal.