bluuebunny/crossref_metadata_2025 huggingface dataset:
Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor
Authors: Chen Li , Song Zhenzhen , Cao Xiaowan , Fan Mingsong , Zhou Yan , Zhang Guoying
Published: August 2022

Background:

Inflammation is currently recognized as one of the major causes of premature delivery. As a member of the interleukin-1β (IL-1β) family, interleukin-33 (IL-33) has been shown to be involved in normal pregnancy as well as a variety of pregnancy-related disorder. This study aims to investigate the potential function of IL-33 in uterine smooth muscle cells during labor.

Methods:

Myometrium samples from term pregnant (≥37 weeks gestation) women were either frozen or cells were isolated and cultured. Immunohistochemistry and western blotting were used to assess the distribution of IL-33. Cultured cells were incubated with lipopolysaccharide (LPS) to mimic inflammation as well as in the presence of 4μ8C (IRE1 inhibitor III) to block endoplasmic reticulum (ER) stress and BAPTA-AM, a calcium chelator.

Results:

LPS reduced the expression of nuclear IL-33 in a time-limited manner and induced ER stress. However, knockdown of IL-33 increased LPS-induced calcium concentration, ER stress and phosphorylation of nuclear factor kappa-B (NF-κB), and P38 mitogen-activated protein kinase (P38 MAPK). In addition, siRNA IL-33 further stimulates LPS enhanced cyclooxygenase-2 (COX-2) expression via NF-κB and p38 pathways. IL-33 expression was decreased in the nucleus with the onset of labor. LPS-induced ER stress and increased expression of the labor-associated gene, COX-2, as well as IL-6 and IL-8 in cultured myometrial cells. IL-33 also increased COX-2 expression, but after it was knocked down, the stimulating effect of LPS on calcium was enhanced. 4μ8C also inhibited the expression of COX-2 markedly. The expression of calcium channels on the membrane and intracellular free calcium ion were both increased which was accompanied by phosphorylated NF-κB and p38.

Conclusions:

These data suggest that IL-33 may be involved in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.

Funding:

This study was supported by grants from the National Natural Science Foundation of China (No. 81300507).
Clone detection for business process models
Authors: Saeedi Nikoo Mahdi , Babur Önder , van den Brand Mark
Published: August 2022

Models are key in software engineering, especially with the rise of model-driven software engineering. One such use of modeling is in business process modeling, where models are used to represent processes in enterprises. As the number of these process models grow in repositories, it leads to an increasing management and maintenance cost. Clone detection is a means that may provide various benefits such as repository management, data prepossessing, filtering, refactoring, and process family detection. In model clone detection, highly similar model fragments are mined from larger model repositories. In this study, we have extended SAMOS (Statistical Analysis of Models) framework for clone detection of business process models. The framework has been developed to support different types of analytics on models, including clone detection. We present the underlying techniques utilized in the framework, as well as our approach in extending the framework. We perform three experimental evaluations to demonstrate the effectiveness of our approach. We first compare our tool against the Apromore toolset for a pairwise model similarity using a synthetic model mutation dataset. As indicated by the results, SAMOS seems to outperform Apromore in the coverage of the metrics in pairwise similarity of models. Later, we do a comparative analysis of the tools on model clone detection using a dataset derived from the SAP Reference Model Collection. In this case, the results show a better precision for Apromore, while a higher recall measure for SAMOS. Finally, we show the additional capabilities of our approach for different model scoping styles through another set of experimental evaluations.
Accurate image-based identification of macroinvertebrate specimens using deep learning—How much training data is needed?
Authors: Høye Toke T. , Dyrmann Mads , Kjær Christian , Nielsen Johnny , Bruus Marianne , Mielec Cecilie L. , Vesterdal Maria S. , Bjerge Kim , Madsen Sigurd A. , Jeppesen Mads R. , Melvad Claus
Published: August 2022

Image-based methods for species identification offer cost-efficient solutions for biomonitoring. This is particularly relevant for invertebrate studies, where bulk samples often represent insurmountable workloads for sorting, identifying, and counting individual specimens. On the other hand, image-based classification using deep learning tools have strict requirements for the amount of training data, which is often a limiting factor. Here, we examine how classification accuracy increases with the amount of training data using the BIODISCOVER imaging system constructed for image-based classification and biomass estimation of invertebrate specimens. We use a balanced dataset of 60 specimens of each of 16 taxa of freshwater macroinvertebrates to systematically quantify how classification performance of a convolutional neural network (CNN) increases for individual taxa and the overall community as the number of specimens used for training is increased. We show a striking 99.2% classification accuracy when the CNN (EfficientNet-B6) is trained on 50 specimens of each taxon, and also how the lower classification accuracy of models trained on less data is particularly evident for morphologically similar species placed within the same taxonomic order. Even with as little as 15 specimens used for training, classification accuracy reached 97%. Our results add to a recent body of literature showing the huge potential of image-based methods and deep learning for specimen-based research, and furthermore offers a perspective to future automatized approaches for deriving ecological data from bulk arthropod samples.
Predictability and transferability of local biodiversity environment relationships
Authors: Jung Martin
Published: August 2022

Background

Biodiversity varies in space and time, and often in response to environmental heterogeneity. Indicators in the form of local biodiversity measures–such as species richness or abundance–are common tools to capture this variation. The rise of readily available remote sensing data has enabled the characterization of environmental heterogeneity in a globally robust and replicable manner. Based on the assumption that differences in biodiversity measures are generally related to differences in environmental heterogeneity, these data have enabled projections and extrapolations of biodiversity in space and time. However so far little work has been done on quantitatively evaluating if and how accurately local biodiversity measures can be predicted.

Methods

Here I combine estimates of biodiversity measures from terrestrial local biodiversity surveys with remotely-sensed data on environmental heterogeneity globally. I then determine through a cross-validation framework how accurately local biodiversity measures can be predicted within (“predictability”) and across similar (“transferability”) biodiversity surveys.

Results

I found that prediction errors can be substantial, with error magnitudes varying between different biodiversity measures, taxonomic groups, sampling techniques and types of environmental heterogeneity characterizations. And although errors associated with model predictability were in many cases relatively low, these results question–particular for transferability–our capability to accurately predict and project local biodiversity measures based on environmental heterogeneity. I make the case that future predictions should be evaluated based on their accuracy and inherent uncertainty, and ecological theories be tested against whether we are able to make accurate predictions from local biodiversity data.
The high diversity of gametogenic pathways in amphispermic water frog hybrids from Eastern Ukraine
Authors: Pustovalova Eleonora , Choleva Lukaš , Shabanov Dmytro , Dedukh Dmitrij
Published: August 2022

Interspecific hybridization can disrupt canonical gametogenic pathways, leading to the emergence of clonal and hemiclonal organisms. Such gametogenic alterations usually include genome endoreplication and/or premeiotic elimination of one of the parental genomes. The hybrid frog Pelophylax esculentus exploits genome endoreplication and genome elimination to produce haploid gametes with chromosomes of only one parental species. To reproduce, hybrids coexist with one of the parental species and form specific population systems. Here, we investigated the mechanism of spermatogenesis in diploid P. esculentus from sympatric populations of P. ridibundus using fluorescent in situ hybridization. We found that the genome composition and ploidy of germ cells, meiotic cells, and spermatids vary among P. esculentus individuals. The spermatogenic patterns observed in various hybrid males suggest the occurrence of at least six diverse germ cell populations, each with a specific premeiotic genome elimination and endoreplication pathway. Besides co-occurring aberrant cells detected during meiosis and gamete aneuploidy, alterations in genome duplication and endoreplication have led to either haploid or diploid sperm production. Diploid P. esculentus males from mixed populations of P. ridibundus rarely follow classical hybridogenesis. Instead, hybrid males simultaneously produce gametes with different genome compositions and ploidy levels. The persistence of the studied mixed populations highly relies on gametes containing a genome of the other parental species, P. lessonae.
Fine sand facilitates egg extrusion and improves reproductive output in female mud crab genus Scylla
Authors: Fazhan Hanafiah , Waiho Khor , Shu-Chien Alexander Chong , Wang Youji , Ikhwanuddin Mhd , Abualreesh Muyassar H. , Kasan Nor Azman , Wu Qingyang , Muda Sabri , Sor Chin Siang , Jalilah Mohamad
Published: August 2022

Mud crabs (genus Scylla) are gaining attention as potential aquaculture species due to their lucrative market price and high demand. One of the essential components of mud crab culture is broodstock quality. The optimisation of mud crab broodstock culture currently focused on its nutritional aspects and common rearing parameters, including stocking density and temperature. The use of sandy substrate to induce egg extrusion in female Scylla broodstock is common; however, its optimisation has never been conducted. This study investigated (1) the substrate association of two Scylla species (S. olivacea, S. paramamosain) during broodstock conditioning until egg extrusion when the choices of fine (66.99 ± 14.48 μm) and coarse (656.17 ± 38.13 μm) sands were given; (2) the female reproductive output when S. olivacea females were individually exposed to either fine sand, coarse sand, or no sand treatments. Females, spawners and non-spawners, of S. olivacea and S. paramamosain were associated with fine sand and none was observed to bury in the coarse sand tray. The occurrence of egg extrusion was not significantly different between species but moderately associated with the duration of visits (stayed in sand for 1 d, 2 d, ≥3 d). The final incubation period in the sand tray was more than 2 days in all cases, except for one female S. paramamosain (buried in the sand for 1 day prior to egg extrusion). When no choice was available, the highest percentage (58.3%) of females extruded eggs in fine sand treatment, followed by coarse sand treatment (33.3%), and no sand treatment (8.3%). Sand type influenced the weight of egg clutch, total egg number, fecundity, and clutch size. These results suggest that fine sand (<70 μm) substrate should be incorporated into Scylla broodstock rearing to maximise female reproductive output.
Perception and Attitude of Students and Teaching Faculty on Continuous Cumulative Evaluation System in Dental Education
Authors: Venkatesh Rashmi , Bargale Seema , Shah Monali
Published: August 2022

Introduction: Continuous Cumulative Evaluation System (CCES) is an innovative formative evaluation system practiced in Sumandeep Vidyapeeth which is located in Gujarat, India. The CCES is carried out during the conduct of course and every undergraduate student is evaluated for his/her performance in theory lectures and/or in clinical and/or practical classes daily. The cumulative marks secured by the student for entire academic year is calculated and part of it goes as internal assessment marks which will be added to their summative evaluation. Aim: To evaluate the perception and attitude of dental students and teaching faculty regarding CCES. Materials and Methods: In this cross-sectional study, selfprepared validated questionnaires were distributed amongst dental students and teaching faculty of K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India. Total 42 faculty questionnaire and 300 student questionnaires were distributed. Questionnaire for teaching faculty consisted of eight questions while questionnaire for students consisted of six questions. Collected data from filled questionnaires were subjected to descriptive statistics and the significance of differences among responses depending on seniority of faculty in faculty group and by year of study in student group was determined by Chi-square test. Results: The response rate of the study questionnaire was 83.33% (n=35) and 92% (n=276) for faculty and students respectively. Both students (100%) and the faculty (91.42%) were open to implementation of newer evidence-based evaluation methodologies in curriculum. The junior faculty felt (n=14, 82.35%) difficulty in adapting to CCES system. Both faculty (n=24, 68.57%) and students (n=257, 93.11%) agreed that CCES in every lecture has increased the students attentiveness in theory class. Conclusion: The CCES as an innovative evaluation system is well accepted by teaching faculty and students of K M Shah Dental college and Hospital, Sumandeep Vidyapeeth.
Conventional Shaping into CNC Machine Tool Remanufacturability Assessment
Authors: Mubarak Ethar Mohammed , Ridha Ali Zuhair , Ghazi Sara Saad , Abdulrazaq Ekhlas Ahmad , Abdullah Ziyad Tariq
Published: August 2022

Aims: Remanufacturability Index (RI) was calculated to indicate the ability of remanufacturing conventional shaping into CNC machine tool through multi-criteria assessment methodology.

Place and Duration of Study: Middle Technical University, Institute of Technology-Baghdad, Mechanical Techniques School, between 2021/2022.

Methodology: Conventional shaping machines which are remanufactured-upgraded into CNC machine tools were analyzed to classify a group of seven remanufacturing-upgrading alternatives. Multi-criteria were defined include cost, time, accuracy and complex shape, reliability, processing range and efficiency and ergonomic. Weighting of importance of criteria and performance of alternatives were conducted by applying comparative literature analysis and machine tool remanufacturing experience analysis of mechanical structure of remanufactured-upgraded conventional shaping into CNC machine tool as well as alternatives performances scoring.

Results: As many as the number of automated axes, as high as the Remanufacturability Index (RI) which is dedicated to remanufactured-upgraded conventional shaping into 2-axis to 5-axis CNC machine tool.

Conclusion: Remanufactured-upgrading conventional shaping into CNC machine tool is of high remanufacturing potentials that satisfy conditions of technical, economic and environmental feasibilities.
Development and Evaluation of Multifunctional Tillage Implement
Authors: Kumar A. Ashok , Anil Kumar C. , Chakrapani V. , Rajesh D. , Rao N. Seshagiri
Published: August 2022

To improve the mechanization level in India, a low-cost tractor that can be afforded by a normal farmer and also suitable for Indian land size is very much required. One way to reduce the cost of mechanization is optimum utilization of the tractor power for any agricultural operation. For these matching, implements are required for the developed tractor which can use the tractor rated power optimally. To further reduce the cost of operation, two tillage operations can be combined by combining two implements. Hence, a combined Cultivator and Disk Harrow (C-DH) was developed and tested in the Research Farm of College of Agricultural Engineering, Madakasira. The tests were carried out with two speeds and three different depths in each speed. The plots of 50×25m size were selected for the test parameters such as the speed of operation. The time required to travel 25m test length, turning time, depth of operation, the width of operation were recorded. Quality of work was judged by the Mass Median Diameter (MMD) of soil aggregates collected before and after operating C-DH implement in the plot and conducting sieve analysis. From the test results, the average field capacity of the C-DH implement was found to be 0.30 and 0.61 ha/h at 1.8 and 3.4 km/h respectively. The overall performance was expressed in term of Performance Index and was found to be 548.54 at the depth of 13 cm and a speed of 3.4 km/h.
Prevalence and Clinical Aspects of Hemophilia in the Western Region of Cameroon
Authors: Tuono Romaric De Manfouo , Tazemda Gildas Boris Kuitsouc , Tambo Ernest , Njajou Omer
Published: August 2022

Introduction: Hemophilia is a constitutional defect in blood clotting related to a clotting factor deficiency. Its remains a major public health problem, mainly due to ignorance of the disease, limited screening capacities and access to treatment in sub-Saharan Africa and particularly in Cameroon. It causes heavy bleeding in the absence of adequate management. Few reports are available about the disease in countries with limited resources. This study assess the occurrence of hemophilia in the Western region of Cameroon and clinical aspects with the aim of raising public awareness of the disease.

Methods: A cross-sectional and descriptive study was carried out over a period of 04 months in 5 departments of the Western region of Cameroon, in particular Mifi, Ndé, Bamboutos, Haut Nkam and Menoua. The individuals were selected in their houses on the basis of clinical arguments, i.e. bleeding from the gums, traumatic wounds, hematomas. The blood samples taken from the latter were analyzed in the hemostasis laboratory of the Regional Hospital of Bafoussam. The epidemiological characteristics of hemophiliacs identified and suspects hemophiliacs were analyzed. The results obtained were analysed using statistical software R version 4.1.1.

Results: Out of 5995 people selected, 13 (0.22%) cases of hemophilia were identified, 09 confirmed cases and 04 new cases. The mean age of the patients was 14.85 years old (1.5-49). The disease was discovered mainly during circumcision in the months following birth (9/13, 69.23%), and by bleeding of the gums (9/13, 69.23%). Clinical signs were pain of the joints (46%), hematoma and swelling of the joints (38%). Platelets counts and prothrombin rate were normal in all. However, a prolonged Cephalin + Activator Time was found; it was corrected by supplying normal control plasma.

Conclusion: Hemophilia is a pathology little known for the general public. For this, with the help of public authorithies, continuing education sessions must be set up to raise awareness among the population in order to limit the transmission of the disease and to eradicate this scourge which constitutes a real public health problem.
Assessing the Current Alterations to the Estuarine Ecosystem in Southwest Nigeria
Authors: M. Olusanya Adeyinka
Published: August 2022

The estuarine ecosystem provides services that are economically and ecologically indispensable, and these services offer support to human well-being. However, uncontrolled human activities have altered the ecosystem goods and services provision, thus resulting in numerous irreversible ecological losses in the wetlands. Globally, studies have used many approaches and paradigms to manage estuarine ecosystems, yet a limited management mechanism exists in the Nigerian estuarine ecosystems. This study investigated the human dimensions of the alterations of the estuarine ecosystems in Southwest Nigeria over 20 years and used the result to inform decision-making. This study also used remotely sensed datasets (Operational Land Imager and Thermal Infrared (OLI/TIRS) and Enhance Thematic Mapper (ETM)) from the United State Geological Survey (USGS) Earth Explorer as references to determine the estuarine ecosystems coverage and loss. The reference datasets were combined and overlaid on the Nigerian wetland data to conduct a change analysis. Maximum Likelihood Classification in ArcGIS was conducted to determine the ecosystem coverage and loss. The study also conducted a qualitative assessment of the concerned management agencies to understand the questions of the environmental, ethical, governance, economics, decision making and policy implementation that shape estuarine ecosystems management in the study area. The result of this study indicates that 6405 hectares (38.1%) of the estuarine coverage in 2001 has been depleted in 2021, and management activities are traditional, nonsequential, and deficient. The drivers of alterations identified are mainly anthropogenic activities and climate change. The implications include loss of valuable fish species, pollution, habitats and biodiversity loss. Therefore, this study recommended the Ecosystem-Based Management approach to determine all essentials of the success or failure of ecosystem goods and services supply, resource use efficiency, and stability of estuarine ecosystems in Southwest Nigeria.
Tang Hanedanlığı ve Türk Kağanlığı İlişkileri Bağlamında Xueyantuo (Sir-Tarduş, Seyanto; 薛延陀) Hanlığı
Authors: Aktaş Şükrü
Published: August 2022

Xue Yantuolar (薛延陀), Çin Halk Cumhuriyeti kuzeyinde yaşamış bir ulustur. Köken olarak Tiele’lar ile akrabadırlar hatta Tie-ler’ların bir koludurlar. Kültürleri, toplumsal adet ve yapıları, Eski Türk devletlerinden Göktürk Devleti ve Türk ve Türk soylu halklarınki ile büyük oranda benzeşmektedir. Sui hanedanlığından, Tang hanedanlığının ilk yıllarına kadar, Xue Yantuo’lar, Türk kağanlığına yakındı. Xie-li Kağan (颉利可汗) döneminde, Xue Yantuolar, Doğu Türk Kağanlığını arkadan vurup Tang (唐) yönetiminin o dönem başında bulunan Taizong ile işbirliğine gitmişti. Daha sonra Yinan Kağan döneminde ise Xue Yantuo’lar, hem Türk Kağanlığı (突厥汗国) hem de Tang yönetimi ile çekişmeye girmiştir. Giriştikleri bu çekişmeden hemen önce Xue Yantuo hükümdarı Yinan Kağan’ın (夷男) ölmesi, orta Asya topluluklarında yaşanan tipik bir olaya Xue Yantuo’ların da tutulmalarına sebep olmuştur. Bunun neticesinde de Xue Yantuo’ların meydana getirdikleri birlik, dağılma sürecine götürmüş, birliğin yitirilmesine ve tarih sahnesinden silinmelerinin sebebi olmuştur. Ms. 646 yılında da tamamen dağılıp ve silinmişlerdir. Bu çalışmada Xue Yantuo’ların genel tarihi durumları, isimleri, yaşadıkları ve hüküm sürdükleri coğrafya ve kısa tarihleri üzerine inşa edilmiştir. Çalışmada klasik Çin tarih metinlerinden olan Tong Dian’den (通典) ağırlıklı olarak istifade edilmiştir. Klasik metinlerden alıntılanan tümce ve deliller asıl halleri ile kullanılmıştır. Xue Yantuo ismi, Çince imlerin Latin harfleri ile çağdaş yazım sistemi olan Pin-Yin (拼音) sistemi ile kullanılmıştır.
SOĞUK SAVAŞ YILLARINDA TÜRK SİNEMASI NDA SOL DÜŞÜNCE: GENÇ SİNEMACILAR TOPLULUĞU VE DEVRİMCİ SİNEMA TARTIŞMALARI (1968-1971)
Authors: Kocaoğlu Ceyda Tuna
Published: August 2022

20.Yüzyılda siyasal ve toplumsal yaşamın en önemli
dönemlerden biri Soğuk Savaş yılları olmuştur. 1945’te II.
Dünya Savaşı’nın sonrasında başlayan ve hemen hemen
yüzyılın sonuna kadar devam eden Soğuk Savaş sadece iki
büyük gücün, ABD ve Sovyet Rusya, uluslararası
ilişkilerde yürüttüğü kıyasıya bir mücadele olarak
kalmamıştır. Hemen bütün dünyada birçok ulusun
yaşamında derin etkiler bırakmıştır. Bir tarafta
kapitalizmin savunucusu ABD, diğer tarafta Sovyet Rusya
kendi inandıkları siyasal ve toplumsal düzeni hâkim kılma
adına büyük bir mücadelenin içine girmişler bu mücadele
başta yakın çevre ülkeleri olmak üzere kısa süre içinde tüm
dünya milletlerinin mücadelesi haline gelmiştir. Daha da
ilginç olanı mücadelenin siyasal kurum ve ortamların
dışına çıkarak toplum hayatının tüm alanlarında etkili
olmasıdır. Bu alanlardan biri de sinema olmuştur.
Özellikle 1968 yılından itibaren sanatın hemen her
alanında kendi taraftarlarını ortaya çıkaran bu mücadele
sinemada çok daha ön planda olmuştur. Türkiye’de de
1968 yılından itibaren sinema sol ve sağ düşüncelerin
rekabet alanlarından biri haline gelmiştir. Bu çerçevede sol
çevrelerce kurulu düzenin sineması olarak görülen
Yeşilçam’ın karşısında Devrimci sinema anlayışıyla
ortaya çıkan Genç Sinemacılar Topluluğu, Genç Sinema
Dergisi etrafında bir araya gelerek büyük bir mücadele
başlatmışlardır. Başta Yeşilçam’ın batı emperyalizminin
etkisindeki sinema anlayışı olmak üzere hükümetin sansür
aracılığıyla sinema üzerinde kurmak istediği baskı Genç
Sinemacılar Topluluğunun sert eleştirilerine hedef
olmuştur. Bu çalışmada, Genç Sinema Dergisinde kaleme
alınan yazılar çerçevesinde 1968-1971 yılları arasında
Yeşilçam’a karşı yürütülen mücadele ve sinemada
oluşturulmaya çalışılan devrimci sinema anlayışı ele
alınarak incelenmeye çalışılacaktır
Endovascular management of compression syndromes associated with pelvic venous disease
Authors: Wikkeling Marald , Jalaie Houman
Published: August 2022

Compression syndromes play an important role in pelvic venous disease (PeVD). Although compressive lesions of the common iliac and renal veins are common on non-invasive imaging studies, they are usually asymptomatic and the factors associated with the development of symptoms remain poorly understood. The prevalence of pelvic or lower-extremity symptoms and varicose veins caused by compression of an iliac or left renal vein is unknown. However, a high index of suspicion is needed in the work-up of PeVD, particularly in patients who are refractory to the initial treatment. Once a symptomatic compression syndrome is discovered in a PeVD patient, this should be treated first. After treating compression syndromes, there should be a waiting period to notice if the complaints and symptoms diminish.
Future perspective on treatment of pelvic venous disease
Authors: Doğancı Suat , Lazarashvilli Zaza
Published: August 2022

Pelvic venous disease (PeVD) as a terminology incorporates many different pathologies in pelvis in both men and women. There are still many question marks in this area that need to be answered. In this article, we attempt to highlight the areas of where we should focus on for future research topics.
THE MODERATOR EFFECT OF FINANCIAL APPS ON THE RELATIONSHIP BETWEEN FINANCIAL EDUCATION AND FINANCIAL CAPABILITY
Authors: Linawati Nanik , Wijaya Inlian
Published: August 2022

This study aims to determine the effect of Socio-Demographic and Financial Education on Financial Capability with Financial Apps as the moderator variable. The research population is Generation Z aged 19-26 years. The research sample amounted to 100 respondents and data collection was done through the distribution of questionnaires via google form. The data analysis method used is Partial Least Square (PLS). In the industrial era 4.0, which is growing rapidly at this time, financial applications that are designed to help people manage finances have begun to appear. Digital financial management applications make people manage personal finances easily and practically. Financial management applications encourage people to further upgrade their knowledge about financial management to achieve financial goals in the future. The results showed that gender had a significant effect on financial capability and financial apps played a role in moderating the influence of gender on financial capability.
VARIANCE GAMMA MODEL AND ITS DEVELOPMENT FOR STOCKS CALL OPTION PRICES ESTIMATION
Authors: Paskalia Bernadet Hilga Palma , Nugraha Ruth Cornelia , Wirawan Dhestar Bagus
Published: August 2022

One of the developments in the options market is the formation of various pricing models for an option to help the buyer determine the fairness of the price. Black-Scholes model uses the assumption that the log return price of stocks is normally distributed, while in reality, the real-world price couldn’t fit into that assumption. To be able to obtain an option price calculation that considers skewness and kurtosis in the stock price data, there are many alternative methods, namely Black-Scholes with Gram-Charlier expansion and Variance Gamma models. As a development of the Variance Gamma model, there are also several methods that are able to reduce the simulations variance generated by the Variance Gamma model, namely Antithetic Variate Variance Gamma model and the Importance Sampling Variance Gamma method. For the results, the Importance Sampling Variance Gamma model and the Antithetic Variate Variance Gamma model are really able to reduce the resulting simulations variance so that it can produce more accurate option prices with market prices compared to the Variance Gamma model. In the end, all Variance Gamma models are able to produce a call option price that is more in line with the market price than all Black Scholes models.
AN ASSESSMENT OF FACTORS AFFECTING THE PROFITABILITY OF FIRMS IN CASE OF CHIRO TOWN TRADERS
Authors: Malela Ismael Hussein , Abdula Abdela Ahmed
Published: August 2022

Trade is recognized as an important vehicle of economic growth, employment creation, income generation, and poverty reduction. As a result, trade occupies a prominent position in the development agenda of Ethiopia. The main objective of this study is to assess factors affecting firms of profitability in the case of Chiro town traders. From a total population, 93 sample respondents were identified using a simple random sampling technique. The findings from the study conducted revealed that most trader's businesses lack finance. Credit constraints operate in a variety of ways in Chiro town where undeveloped capital forces the trader to rely on self-financing or borrowing from friends or relatives. Lack of access to long-term credit forces traders in the town to rely on high-cost, short-term finance. Poor housing poses a major challenge to the business growth of traders in Chiro town. By encouraging the development of the construction sector oriented towards low-income groups, the government would address the housing problems affecting the business growth of traders. Finally, based on findings the researcher recommends Trader’s support program should have to be based on the identified critical factors. Major problems like lack of education, lack of working capital, and others that traders in the town face need to be addressed by prioritizing them following their severity as well as the availability of resources to run the operation. The loan repayment period for most traders was 1-2 years. The government should therefore establish friendly small loaning systems which would include low-interest rates to ensure continuity of these trader businesses.
AS MÚLTIPLAS FACES DA EXCLUSÃO NAS LUTAS PELA CIDADANIA
Authors: Scherer-Warren Ilse
Published: August 2022

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TRABALHO E NOVAS SOCIABILIDADES
Authors: Lima Jacob Carlos
Published: August 2022

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GÊNERO, IDADES E GERAÇÕES
Authors: Britto da Motta Alda
Published: August 2022

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HABLEMOS DEL DELITO: la compleja relación entre el orden normativo y la realidad social
Authors: Pegoraro Juan S.
Published: August 2022

O artigo aborda a questão da ordem social e das práticas ilegais como uma realidade observável e constitutiva das relações sociais que definem esta ordem. Propõe que a visão da sociologia sobre a “sociedade” é insuficiente e ocultadora da realidade existente. Mesmo quando as ações sociais assumem formas cooperativas ou organizadas, estas não são incompatíveis com a existência de práticas ilegais que repercutem na estrutura social e afetam as relações de dominação política e econômica. Em resumo, ao contrário do que pensam muitos teóricos, as práticas ilegais contribuem para a constituição e reprodução da ordem social. PALAVRAS-CHAVE: ordem social, normas, ação social, práticas ilegais, dominação.LET’S TALK ABOUT THE FELONY – the complex relationship between normative order and social reality Juan S.Pegoraro This paper approaches the issue of social order and illegal practices as an observable reality constituting the social relations defining this social order. It proposes that sociology’s vision of society is insufficient and hides existing reality.Even when social actions take cooperative or organized shapes, they are not incompatible with the existence of illegal practices that affect the social structure and affect the political and economic dominance relations. Summing up, contrary to many thoretician’s thoughts, illegal practices help the reproduction and constitution of the social order. KEYWORDS: social order, rules, social actions, illegal practices, domination.PARLONS DU DÉLIT – la relation complexe entre l’ordre normatif et la réalité sociale Juan S.Pegoraro Cet article traite de l’ordre social et des pratiques illégales en tant que réalité observable et constitutive des relations sociales qui sont à la base de cet ordre. On y estime que le regard de la sociologie sur la “société” est insuffisant et masque la réalité existante. Même lorsque les actions sociales prennent des formes coopératives ou organisées, elles ne sont pas incompatibles avec l’existence de pratiques illégales ayant des répercussions sur la structure sociale et une influence sur les relations de domination politique et économique. En synthèse, contrairement à ce que pensent de nombreux théoriciens, les pratiques illégales ont une influence sur la constitution et la reproduction de l’ordre social. MOTS-CLÉS: ordre social, normes, règles, pratiques illégales, domination.Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
A ANTROPOLOGIA EM XEQUE: em busca de um novo olhar antropológico
Authors: Trigueiro Aline
Published: August 2022

Através da recuperação de textos de vários autores, este artigo objetiva refletir sobre os atuais rumos da prática antropológica frente às transformações do mundo contemporâneo. Trata-se, na verdade, de explorar quais os dilemas e as nova  perspectivas que estão sendo produzidos na tentativa de aproximar o “ofício do antropólogo” de um mundo que se transforma. Tentaremos identificar, ainda, como as mudanças no cenário mundial – descolonização, globalização – podem ser capazes de abrir outras possibilidades para que as diferenças culturais sejam interpretadas. Além disso, temos a intenção de traçar um panorama da prática antropológica na atualidade, apontando as principais tensões enfrentadas pela mesma, sobretudo, no quesito como compreender “o outro” e a sua cultura? PALAVRAS-CHAVE: olhar antropológico, globalização, etnocentrismo, modernidade, pós-modernidade.THE ANTHROPOLOGY IN CHECK: in search of a new anthropological point of view Aline Trigueiro Through the analysis of texts by many authors, this paper intends to discuss the current directions of the anthropological practice regarding the transformations of the contemporary world. It is about, actually, exploring which dilemmas and new perspectives are being produced in the attempt to approximate the “anthropologist’s living” to a changing world. We will also try to identify how changes in the world scenery – descolonization, globalization – can open other possibilities to interpret cultural differences. Besides, we intend to draw a panorama of the current anthropological practice, pointing the main tensions it faces, specially, in the issue of understanding “the other” and their culture? KEYWORDS: anthropological point of view, globalization, ethnocentrism, modernity, post-modernity.L’ANTHROPOLOGIE EN ÉCHEC: a la recherche d’un nouveau regard anthropologique Aline Trigueiro Par l’analyse de textes de plusieurs auteurs, cet article se veut d’être une réflexion sur les tendances actuelles de la pratique anthropologique face aux transformations du monde contemporain. Il s’agit plus exactement d’explorer les dilemmes et les nouvelles perspectives produits pour essayer de rapprocher “le travail de l’anthropologue” d’un monde qui se transforme. Nous essayons aussi d’identifier comment les changements qui ont lieu sur la scène mondiale – décolonisation, mondialisation – sont capables d’ouvrir de nouvelles perspectives pour que les différences culturelles puissent être interprétées. De plus, notre intention est de tracer un panorama de la pratique anthropologique dans l’actualité, en montrant les principales tensions qu’elle affronte, surtout quant à la question de comprendre “l’autre” et sa culture. MOTS-CLÉS: regard anthropologique, mondialisation, ethnocentrisme, modernité, post-modernité.Publicação Online do Caderno CRH:http://www.cadernocrh.ufba.br
Políticas e Guerras da cultura: filtros de investimento público como "pós-censura"
Authors: Paula Leandro de , Dumas Caroline , Pimenta Fernanda
Published: August 2022

Este artigo investiga a relação entre o ambiente de "guerra cultural" no Brasil e o regime de moderação de liberdades expressivas conhecido como "pós-censura", analisando como os dois fenômenos se interligam na gestão de fundos públicos de incentivo à cultura pelo governo Bolsonaro. Reconstituímos os desdobramentos jurídicos e políticos de três medidas da Secretaria Especial de Cultura entre 2019 e 2021: a suspensão de um edital para TVs públicas; a inabilitação do Instituto Vladimir Herzog para captação de recursos; e a paralisação da análise de projetos previstos para cidades que adotassem ações de lockdown . Decisões judiciais, notas de órgãos de governo, material de imprensa e de redes sociais compõem o corpus, examinado sob as premissas da análise de controvérsias públicas.
Sleep Disorders Among Individuals With Rheumatoid Arthritis
Authors: Katz Patricia , Pedro Sofia , Michaud Kaleb
Published: August 2022

Objective

Self‐reported sleep problems are common in rheumatoid arthritis (RA), with potential negative health implications, yet relatively little research has focused on sleep in RA. We examined the prevalence of obstructive sleep apnea (OSA) risk, restless legs syndrome (RLS) symptoms, and short sleep (SS) in a large RA cohort (n = 4,200) and factors associated with each.

Methods

Data are from FORWARD, The National Databank for Rheumatic Diseases. Validated screening measures assessed OSA risk and RLS symptoms. SS was based on self‐reported average sleep time (<6 hours). The Medical Outcomes Study Sleep Problems Index I measured self‐reported sleep quality. Multivariable logistic regression models identified independent predictors of sleep disorders and sleep quality and the independent association of OSA risk, RLS symptoms, and SS with self‐reported poor sleep quality.

Results

Twenty‐one percent (n = 899) had OSA diagnosis or risk, 30% (n = 1,272) had RLS symptoms or diagnosis, and 43% (n = 1,737) reported SS, and RA disease activity was associated with each sleep disorder. Abatacept use was associated with lower odds of RLS and SS. Use of conventional disease‐modifying antirheumatic drugs or abatacept was less frequent in the SS group. No medications were associated with OSA in multivariable analyses. Both RLS and SS was associated with worse perceived sleep quality.

Discussion

Almost two‐thirds met criteria for at least one sleep disorder. RA disease activity and pain were significantly associated with each sleep condition. Additional research is needed to identify the causal pathway between sleep disorders and RA disease activity and pain and the long‐term consequences of sleep disorders in RA.
Training‐on‐a‐Chip: A Multi‐Organ Device to Study the Effect of Muscle Exercise on Insulin Secretion in Vitro
Authors: Fernández‐Costa Juan M. , Ortega María A. , Rodríguez‐Comas Júlia , Lopez‐Muñoz Gerardo , Yeste Jose , Mangas‐Florencio Lluís , Fernández‐González Miriam , Martin‐Lasierra Eduard , Tejedera‐Villafranca Ainoa , Ramon‐Azcon Javier
Published: August 2022

Organ‐on‐a‐chip (OOC) devices bring innovative disease modeling and drug discovery approaches by providing biomimetic models of tissues and organs in vitro combined with biosensors. Miniaturized biosensor systems and tissue biofabrication techniques allow to create multiple tissues on a chip highly controlling the experimental variables for high‐content screening applications. In this work, a biomimetic multi‐OOC integrated platform composed of skeletal muscle and pancreatic cells is fabricated to study the impact of exercise on insulin secretion. Both engineered tissues are integrated with optical biosensing technology to monitor in real‐time the contraction‐induced myokine secretion and their effect on beta‐cells insulin production. Using this device, it is demonstrated that insulin secretion is induced directly by the effect of myotubes contractions. The cross‐talk platform would improve drug assays and provide a new model to study the loss of pancreas functionality associated with diabetes mellitus.
White matter hyperintensities in former American football players
Authors: Alosco Michael L. , Tripodis Yorghos , Baucom Zachary H. , Adler Charles H. , Balcer Laura J. , Bernick Charles , Mariani Megan L. , Au Rhoda , Banks Sarah J. , Barr William B. , Wethe Jennifer V. , Cantu Robert C. , Coleman Michael J. , Dodick David W. , McClean Michael D. , McKee Ann C. , Mez Jesse , Palmisano Joseph N. , Martin Brett , Hartlage Kaitlin , Lin Alexander P. , Koerte Inga K. , Cummings Jeffrey L. , Reiman Eric M. , Stern Robert A. , Shenton Martha E. , Bouix Sylvain ,   for the DIAGNOSE CTE Research Project
Published: August 2022

Introduction

The presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden and distribution of WMH, and their association with years of play, age of first exposure, and clinical function in former American football players.

Methods

A total of 149 former football players and 53 asymptomatic unexposed participants (all men, 45–74 years) completed fluid‐attenuated inversion recovery magnetic resonance imaging, neuropsychological testing, and self‐report neuropsychiatric measures. Lesion Segmentation Toolbox estimated WMH. Analyses were performed in the total sample and stratified by age 60.

Results

In older but not younger participants, former football players had greater total, frontal, temporal, and parietal log‐WMH compared to asymptomatic unexposed men. In older but not younger former football players, greater log‐WMH was associated with younger age of first exposure to football and worse executive function.

Discussion

In older former football players, WMH may have unique presentations, risk factors, and etiologies.

Highlights

Older but not younger former football players had greater total, frontal, temporal, and parietal lobe white matter hyperintensities (WMH) compared to same‐age asymptomatic unexposed men.

Younger age of first exposure to football was associated with greater WMH in older but not younger former American football players.

In former football players, greater WMH was associated with worse executive function and verbal memory.
Supercritical CO2 foaming of open‐cell polypropylene/ethylene propylene diene monomer composite foams with oriented cellular structures for water treatment
Authors: Huang Pengke , Wu Fei , Su Yaozhuo , Luo Haibin , Lan Xiaoqin , Lee Patrick C. , Zheng Wenge
Published: August 2022

Efficient treatment of tiny media in wastewater is a global challenge. Herein, an ingenious design to fabricate the highly open‐cell polypropylene (PP)/ethylene propylene diene monomer (EPDM) composite foams for water treatment by using supercritical CO2 (scCO2) extrusion foaming coupling with post‐stretching is presented. The tensile strain of high melt strength PP is fully utilized in an extensional flow field during foaming. Meanwhile, EPDM is added into PP matrix for obtaining the highly open‐cell and oriented porous structures. Interestingly, a variety of structural transformations (like uniform, hollow and oriented cellular structures) can be achieved during extrusion foaming. Furthermore, the effects of different cellular structures on their selective filtration properties are studied. More interestingly, the as‐prepared composite foam strips, with the highly open‐cell content (~94.4%) and orientation degree (~89.6%), exhibit excellent selective filtration performance, which can successfully remove waste with particle size larger than 1 μm (its filtration efficiency:~ 99.52%). Water droplets can easily pass through the lengthy foam strips in seconds, but tiny particles (like oil droplets or glass microbeads) will be blocked. This work provides a new pathway to prepare highly open‐cell composite foams with anisotropic porous structures for water treatment.
Cranial osteology of a juvenile specimen ofAcratocnus ye(Mammalia, Xenarthra, Folivora) and its ontogenetic and phylogenetic implications
Authors: Gaudin Timothy J. , Scaife Thomas
Published: August 2022

The present study comprises a description of the skull and jaw anatomy of a juvenile specimen of the Antillean slothAcratocnus ye, from the Holocene of Haiti. Detailed descriptions and illustrations are provided of the skull bones and their sutural connections, which normally fuse in adults. Descriptions are also provided for the mandible and ear ossicles, as well as endocranial surfaces and sinuses exposed by breaks. The anatomy of our juvenileA. yeis compared to that of adultA. yeto assess ontogenetic changes in the skull. Several of these ontogenetic features are significant new observations that impact the relationships within Xenarthra as a whole, or between Xenarthrans and other placental mammals, most notably, the presence of a separate mesethmoid element, the presence of alveoli for a lower deciduous canine and anterior incisor, and the presence of separate rostral and caudal entotympanic elements. A full list of such changes are provided. In addition, the specimen provides information on phylogenetically relevant characters, including features unique to the genusAcratocnus, and features of the clade Choloepodini, includingAcratocnus, the smaller extinct Antillean slothNeocnus, and the extant two‐toed slothCholoepus. Contrary to previous studies,Acratocnusshares as many features withCholoepusas it does with its fellow Antillean formNeocnusin the present study, which is consistent with current morphology‐based phylogenetic hypotheses regarding the relationships within Choloepodini. The current study highlights the need for further anatomical and phylogenetic investigations of Antillean sloths (Megalocnidae/Megalonychidae), and juvenile sloths in general.