bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic signs of an unfavorable course of coronary heart disease in patients with type 2 diabetes mellitus
Authors: Urmanova Yu.M. , Mukhtarova Sh.Sh. , Grossman A.B. , Mukhtarova M.Z. , Trigulova R.Kh.
Published: August 2020

Background. Despite the successful development of medical technologies in the diagnosis of coronary heart disease, mortality due to cardiovascular diseases in the population of patients with diabetes mellitus (DM) is not reduced. The development of an algorithm for the early diagnosis of coronary heart di­sease and ways to correct it is a topical problem of cardiology and endocrinology. The purpose is to determine prognostic signs for an unfavorable course of coronary heart disease and develop a table of test probabilities in order to enhance the effectiveness of risk stratification in patients with type 2 DM. Materials and methods. During 2017–2019, there were observed 40 patients (16 men and 24 women) with type 2 DM in combination with coronary heart disease. We took into account the presence of acute myocardial infarction, acute cerebrovascular accidents (stroke), repeated surgical interventions (percutaneous coronary intervention, coronary artery bypass grafting) for the last 3 years. The average age of patients was 65.5 years. Results. In total, 119 signs recorded in the first three days from the moment of patient’s admission were analyzed as possible predictors of an unfavorable prognosis. As markers of coronary heart disease, parameters were adopted that showed the highest occurrence in the group of patients with adverse course of DM and coronary heart disease. The most patho­gnomonic predictors of coronary heart disease progression in patients with type 2 DM were left ventricular systolic dysfunction (ejection fraction < 40 %), systolic blood pressure > 160 mmHg or diastolic blood pressure above 100 mmHg, electrocardiographic signs of myocardial ischemia, persisting upon discharge from the hospital. Conclusions. Criteria that negatively affect the long-term outcome of coronary heart disease in patients with type 2 diabetes are decompensation of DM, in particular, a high level of fasting glycemia (> 13 mmol/l), as well as an increase in total cholesterol and low-density lipoprotein cholesterol.
Clinical and pathogenetic significance of comorbid osteoporosis in diabetes mellitus in women with menopause
Authors: Syniachenko O.V. , Yermolaieva M.V. , Moroziuk D.M. , Verzilov S.M.
Published: August 2020

Background. Osteoporosis is a serious problem due to the high morbidity, mortality and significant costs for medical care. Moreover, in women in the menopausal period, bone fragility due to osteoporosis is more pronounced, and osteoporotic vertebral fractures are three times more common than in men. Type 2 diabetes mellitus (DM) is closely associated with osteoporosis, and some hormonal and peptide markers of bone metabolism simultaneously determine bone mineralization and the state of carbohydrate metabolism. The purpose was to assess the course of diabetes in women during menopause and to study the clinical and pathogenetic relationship with the presence of osteoporosis in them. Materials and methods. Two hundred and sixty-one women with menopause were examined. They were divided into two groups: 17 % with DM (main one) and 83 % without DM (comparison group). In 51 % of cases, osteoporosis was diagnosed (osteopenia and osteoporosis ratio was 4 : 1). The study of carbohydrate metabolism included the determination of insulin resistance HOMA index and the severity of metabolic syndrome, blood levels of insulin, glucose, glycosylated hemoglobin and C-peptide, and markers of bone metabolism were serum parameters of parathyroid hormone, calcitonin, osteocalcin, osteopontin, alkaline phosphatase activity, chemical elements (Ca, P, Mg, Co, Cr, Cu, Mn, Pb, Se, Sr, Zn). Results. DM was diagnosed in 34 % of women with osteoporosis, which directly correlates with their age, frequency and severity of other signs of metabolic syndrome (hyperinsulinemia, hyperlipidemia, hyperuricemia, arterial hypertension, obesity), the absence of cases of normal lipidemia and type IIA lipid metabolism disorders, but with the prevalence of type IIB, a higher rate of alkaline phosphatase activity in the blood and lower values of osteopontin and selenium. Besides, DM severity is closely related to the parameters of mineral bone density and phosphatemia level, and the development of diabetic retinopathy, nephropathy and peripheral macro-/microangiopathy, respectively, depends on the content of selenium, zinc and osteopontin, and the rate of calcemia has prognostic significance. Conclusions. The pathogenetic significance of comorbid osteoporosis, parameters of bone mineral density and markers of bone metabolism in the blood serum of women with menopause in the development of DM, the severity of its course and complications has been proven, and the indicators of osteopontin, calcium, selenium and zinc have prognostic significance.
The effect of obesity on the formation of cancer risk in patients with type 2 diabetes mellitus (literature review)
Authors: Vatseba T.S. , Sokolova L.K. , Pushkarev V.M.
Published: August 2020

The increased risk of cancer in patients with type 2 diabetes mellitus substantiates the relevance of scientific researches on the mechanisms of association of these diseases. It was found that pathogenetic factors of type 2 diabetes mellitus cause disorders at the level of signaling pathways that control the processes of intracellular metabolism and survival. Obesity significantly increases cancer risk. The procarcinogenic effect of obesity is due to a combination of metabolic and hormonal disorders. The role of hyperinsulinemia, hyperglycemia and cytokine imbalance as factors for dysmetabolic influence has been proved. Hyperinsulinemia causes mitogenic and anti-apoptotic effects. Hyperglycemia due to oxidative stress determines chromosomal aberrations and changes in regulatory gene expression. Proinflammatory cytokines promote the formation of chronic inflammation and microenvironment conducive for the survival of malignant cells. Dysmetabolic changes, in turn, cause hormonal disorders that promote carcinogenesis in hormone-dependent organs. Hyperinsulinemia leads to hyperoestrogenemia, and hyperleptinemia disrupts the synthesis of gonadotropic hormones, contributing to hyperplastic endometrial processes. Excessive concentrations of interleukin-6 and hyperleptinemia stimulate local oestrogen synthesis in adipose tissue of the mammary gland, activating proliferative processes. Hypoadiponectinemia promotes suppression of the immune response and indicates a potentially unfavourable course of cancer di­seases. Understanding the mutually confounding pro-oncogenic effects of metabolic and hormonal disorders in obesity should emphasize the importance of body weight correction in patients with diabetes mellitus, as well as in individuals without carbohydrate metabolism disorders, from the standpoint of preventing not only cardiovascular diseases, but also cancer. The choice of antidiabetic drugs should take into account the need for correction of the body weight of patients, and ineffective conservative treatment of obesity is a pretext for the use of bariatric surgery methods according to medical indications.
Аллергические реакции у больных сахарным диабетом 1-го типа (обзор литературы и собственные исследования)
Authors: Kaspruk N.M.
Published: August 2020

В последнее время привлекает внимание рост количества случаев лекарственной аллергии в развитых странах мира. На сегодняшний день до 40 % пациентов стационаров страдают от патологических реакций, связанных с непереносимостью лекарств. Наиболее проблематичными, учитывая существенную ограниченность элиминационных мероприятий, являются аллергические реакции на различные виды инсулинов. Аллергеном может быть не только инсулин, но и белковые (например, протамин) и небелковые (например, цинк) примеси, входящие в состав препаратов. В большинстве случаев аллергия бывает вызвана самим инсулином или его полимерами, о чем свидетельствуют местные аллергические реакции на человеческий инсулин и системные реакции на высокоочищенные инсулины. В обзоре литературы рассматриваются особенности настоящих (НА) и псевдоаллергических (ПА) реакций, сочетание аллергических и псевдоаллергических механизмов. С учетом того что клинические проявления НА и ПА одинаковые, а возможности диагностики разные, подходы к их лечению также отличаются, что вызывает необходимость в проведении дифференциальной диагностики между ними. Провести дифференциальную диагностику на основании только оценки клинической картины заболевания очень сложно, поэтому подходы к диагностике должны иметь комплекс­ный характер. Особое значение при проведении дифференциальной диагностики между НА и ПА имеют данные анамнеза и специфические тесты с причинно-значимыми аллергенами. Приведены результаты ретроспективного анализа историй болезни и амбулаторных карт 170 па­циентов с сахарным диабетом (СД) и положительным аллергическим анамнезом и результаты проведенного анализа эффективности антимедиаторных средств — хифенадина и сехифенадина. Установлено, что частота аллергических реакций у больных СД 1-го типа в 2,9 раза выше, чем в общей популяции, и напрямую зависит от продолжительности и тяжести заболевания. На разные варианты гиперчувствительности к пищевым продуктам указывали 37 % пациентов, медикаментозную гиперчувствительность наблюдали 34 % пациентов (против 27 % в основной группе). Наиболее значимыми аллергенами для обследованных пациентов являются медикаментозные препараты и пищевые продукты. Программа профилактических мероприятий относительно возникновения аллергических заболеваний у больных СД должна включать обучение в отношении питания, элиминационные меры относительно возможных сенсибилизирующих и провоцирующих факторов, адекватную фармакотерапию и предотвращение полипрагмазии. Производные хинуклидина демонстрируют высокую эффективность по лечению аллергодерматозов у больных СД, в частности с гиперчувствительностью к препаратам инсулина.
Корреляция уровня витамина D с гормональным состоянием щитовидной железы и титром антител к рецептору ТТГ у пациентов с болезнью Грейвса
Authors: Pankiv V.I. , Yuzvenko T.Yu. , Koval S.M. , Singh K. , Pankiv I.V. , Sehgal Tarun , Lytvinova O.M.
Published: August 2020

Актуальность. Во многих исследованиях установлена связь дефицита витамина D с аутоиммунными заболеваниями. Доказано, что уровень витамина D у пациентов с ауто­иммунными заболеваниями щитовидной железы, включая болезнь Грейвса, был ниже, чем у пациентов с неаутоиммунными тиреоидными заболеваниями, например токсическим узловым зобом. В то же время в отдельных статьях сообщают об отсутствии такой зависимости между уровнем витамина D и аутоиммунными заболеваниями щитовидной железы. Цель исследования: сравнить уровень витамина D в сыворотке крови у пациентов с болезнью Грейвса и лиц контрольной группы, оценить соотношение содержания витамина D с функциональным состоянием щитовидной железы и титром антител к рецептору тиреотропного гормона (ТТГ). Материалы и методы. Под наблюдением находились 48 пациентов с болезнью Грейвса и 24 здоровых лица контрольной группы. Всем обследованным проводили гормональные исследования, содержащие уровень ТТГ сыворотки, свободного тироксина, свободного трийодтиронина, паратиреоидного гормона, а также определяли уровень ионизированного кальция, 25-гидроксивитамина D (25(OH)D), титр антител к рецептору ТТГ. Результаты. У пациентов с болезнью Грейвса наблюдался достоверно более низкий уровень 25(OH)D (16,3 ± 1,4 нг/мл) по сравнению с показателями контрольной группы (22,8 ± 1,6 нг/мл) (p = 0,024). Уровни ТТГ и титры антител к рецептору ТТГ достоверно отличались между группой лиц с болезнью Грейвса с дефицитом витамина D (25(OH)D < 20 нг/мл) и группой больных с болезнью Грейвса без дефицита витамина D (25(OH)D ≥ 20 нг/мл). Объем щитовидной железы существенно не отличался между этими группами больных. Уровень витамина D в сыворотке крови достоверно взаимосвязан с концентрацией ТТГ и титром антител к рецептору ТТГ у пациентов с болезнью Грейвса. Выводы. Уровень витамина D в сыворотке крови достоверно ниже у пациентов с болезнью Грейвса при сравнении с показателями контрольной группы. У этих пациентов установлена достоверная корреляция между содержанием витамина D и уровнями ТТГ и антител к рецептору ТТГ.
Metode Naive Bayes Classifier – Smoothing pada Sensor Smartphone untuk Klasifikasi Aktivitas Pengendara
Authors: Haniah Mahmudah  , Okkie Puspitorini  , Nur Adi Siswandari  , Ari Wijayanti  , Eliya Alfatekha
Published: August 2020

Sebagian besar penyebab kematian diakibatkan oleh kecelakaan lalu lintas. Makalah ini bertujuan mendapatkan parameter identifikasi aktivitas berkendara yang dapat dikembangkan untuk mendeteksi kecelakaan pada penelitian selanjutnya. Data dikumpulkan dengan memanfaatkan sensor pada smartphone, menggunakan sensor akselerometer dan giroskop. Metode statistik yang diusulkan menggunakan algoritme Naive Bayes Classifiers (NBC) untuk menentukan aktivitas berkendara, dengan membagi dataset ke dalam data latih dan data uji menggunakan beberapa parameter k-fold. Algoritme NBC dapat bekerja dengan sedikit data latih, dengan cara menghitung nilai probabilitas setiap kelas dari perhitungan jumlah rata-rata dan varians setiap fitur untuk mengklasifikasikan kelas secara linier dengan sangat efisien. Hasil menunjukkan bahwa akurasi klasifikasi aktivitas berkendara lebih tinggi apabila terdapat proses smoothing menggunakan metode single exponential smoothing sebelum proses klasifikasi algoritme NBC. Hasil pengujian menggunakan 8 k-fold CV tanpa proses smoothing, dengan smoothing alpha (α) = 0,1, dan dengan α = 0,9 mendapatkan akurasi, berturut-turut, sebesar 98,43%, 99,27%, dan 98,43%. Hasil komparasi metode klasifikasi aktivitas berkendara pada makalah ini membuktikan bahwa metode NBC yang dikombinasikan dengan metode smoothing α = 0,1 menghasilkan akurasi yang lebih besar.
Pengaruh Metode Pengendalian Gulma terhadap Dominansi Gulma serta Pertumbuhan dan Hasil Tanaman Kedelai (Glycine max (L.) Merr.)
Authors: Efendy Dela Yusuf , Yudono Prapto , Respatie Dyah Weny
Published: August 2020

Penelitian ini bertujuan untuk menentukan metode pengendalian gulma yang efektif dan efisien untuk menekan kompetisi yang diakibatkan oleh keberadaan gulma pada pertanaman kedelai. Penelitian ini dilaksanakan di Kebun Tri Dharma Fakultas Pertanian Universitas Gadjah Mada, Banguntapan, Bantul, dan Laboratorium Manajemen dan Produksi Tanaman Departemen Budidaya Pertanian, Fakultas Pertanian, Universitas Gadjah Mada, Daerah Istimewa Yogyakarta pada bulan April hingga Juli 2018. Penelitian menggunakan Rancangan Acak Kelompok Lengkap (RAKL) dengan perlakuan satu faktor dan tiga blok sebagai ulangan. Faktor yang digunakan adalah metode pengendalian gulma yakni: W0 (tanpa pengendalian gulma) sebagai kontrol negatif, W1 (pengendalian gulma secara mekanis pada umur kedelai 1 MST), W2 (pengendalian gulma secara mekanis pada umur kedelai 1 dan 2 MST), W3 (pengendalian gulma secara mekanis pada umur kedelai 1, 2, dan 3 MST), W4 (pengendalian gulma secara mekanis pada umur kedelai 1, 2, 3 dan 4 MST), W5 (pengendalian gulma menggunakan bioherbisida kenikir konsentrasi 400 g.L-1 pada umur kedelai 1 MST), W6 (pengendalian gulma menggunakan herbisida sintetis dosis 200 mL.m-2 pada umur kedelai 1 MST), W7 (pengendalian gulma menggunakan herbisida sintetis dosis 300 mL.m-2 pada umur kedelai 1 MST), W8 (pengendalian gulma menggunakan herbisida sintetis dosis 400 mL.m-2 pada umur kedelai 1 MST), dan W9 (perlakuan bebas gulma) sebagai kontrol positif. Hasil penelitian menunjukkan adanya pengaruh antara perlakuan pengendalian gulma terhadap bobot kering gulma, bobot kering tanaman, laju pertumbuhan tanaman, produktivitas, dan kehilangan hasil tanaman kedelai. Perla kuan pengendalian gulma secara mekanis hingga umur 3 MST (W3) paling efektif dan efisien menekan pertumbuhan gulma dan menghasilkan produktivitas tanaman kedelai setara dengan perlakuan bebas gulma.
Document Preprocessing with TF-IDF to Improve the Polarity Classification Performance of Unstructured Sentiment Analysis
Authors: Alzami Farrikh , Udayanti Erika Devi , Prabowo Dwi Puji , Megantara Rama Aria
Published: August 2020

Sentiment analysis in terms of polarity classification is very important in everyday life, with the existence of polarity, many people can find out whether the respected document has positive or negative sentiment so that it can help in choosing and making decisions. Sentiment analysis usually done manually. Therefore, an automatic sentiment analysis classification process is needed. However, it is rare to find studies that discuss extraction features and which learning models are suitable for unstructured sentiment analysis types with the Amazon food review case. This research explores some extraction features such as Word Bags, TF-IDF, Word2Vector, as well as a combination of TF-IDF and Word2Vector with several machine learning models such as Random Forest, SVM, KNN and Naïve Bayes to find out a combination of feature extraction and learning models that can help add variety to the analysis of polarity sentiments. By assisting with document preparation such as html tags and punctuation and special characters, using snowball stemming, TF-IDF results obtained with SVM are suitable for obtaining a polarity classification in unstructured sentiment analysis for the case of Amazon food review with a performance result of 87,3 percent.
U AND TH IN METASOMATITE OF POKROVKA GOLD DEPOSIT (THE AMUR REGION)
Authors:   NATALIA VALENTINOVNA MOISEENKO  Institute of Geology and Nature Management, FEB RAS, MOISEENKO NATALIA VALENTINOVNA
Published: August 2020

Data on the content of radioactive elements in the metasomatites of the Pokrovskoe gold ore deposit were obtained. It was found that U and Th are scattered in gold-bearing metasomatites. According to the results of the correlation analysis, a positive and negative correlation of U and Th with rare, rare-earth and ore elements in the metasomatites of the deposit was established.
DETERMINATION OF THE OPTIMAL TEMPERATURE RANGE FOR PRE-FIRING KAOLIN
Authors:   TATIANA YURIEVNA ERANSKAYA Institute of Geology and Nature Management, FEB RAS, ERANSKAYA TATIANA YURIEVNA
Published: August 2020

The effect of pre-firing of kaolin concentrates on the yield of aluminum hydroxide during nitric acid leaching by cavitation method is studied. The firing interval of 700-750 ° C is optimal for maximum opening of kaolin concentrate.
TOOLS FOR IMPLEMENTATION OF THE REGIONAL DEVELOPMENT STRATEGY
Authors:   VERA ZAKHAROVNA GRIGORIEVA Amur State University, GRIGORIEVA VERA ZAKHAROVNA
Published: August 2020

The article examines the tools of the regional development strategy, as well as their capabilities.
DEPENDENCE OF THE STABILITY OF THE FERROELECTRIC PHASE OF POTASSIUM NITRATE IN A COMPOSITE WITH BARIUM TITANATE ON THE VOLUME AND SIZE OF INCLUSION PARTICLES
Authors:   NIKITA SERGEEVICH KONTES Amur State University, KONTES NIKITA SERGEEVICH , STUKOVA ELENA VLADIMIROVNA ,   ELENA VLADIMIROVNA STUKOVA Amur State University, GOLUBEVA IRINA ANATOLYEVNA ,   IRINA ANATOLYEVNA GOLUBEVA Amur State University, ZOTOVA OKSANA VASILIEVNA ,   Oksana Vasilievna Zotova Amur State University
Published: August 2020

The results of a study of composites (KNO3) 1 -x /(BaTiO3)x (x = 0.1 and 0.2) are presented. It is shown that the stability of the ferroelectric state of potassium nitrate increases with an increase in the volume fraction of inclusions. It was found that the stability of the ferroelectric phase of potassium nitrate in the composite is also influenced by the particle size of the inclusions. It was revealed that the values of the dielectric constant in the region of the ferroelectric phase increase with an increase in the particle size of the inclusions.
CARTOGRAPHIC ASSESSMENT OF THE CURRENT STATE OF THE FUEL AND ENERGY COMPLEX OF THE AMUR REGION
Authors:   Alexander Nikolaevich Kozlov Amur State University, KOZLOV ALEXANDER NIKOLAEVICH , MIROSHNICHENKO TATIANA ALEXANDROVNA ,   TATIANA ALEXANDROVNA MIROSHNICHENKO Amur State University, SIDOROV EVGENY YURIEVICH ,   EVGENY YURIEVICH SIDOROV LLC «Amur Geoinformation Technologies»
Published: August 2020

The implementation of large projects in the field of transport, gas and chemical industries on the territory of the Amur Region will make it possible to correct the historically formed imbalance in the location of generating power facilities and main consumers. The work presents schematic maps that clearly show the current and future state of the electrical and heat power industry of the Amur region.
Virgin Frontier: Features of Virgin Land Development in Orenburg Region
Authors: Pakhomova Elena V.
Published: August 2020

The present article studies the massive virgin land campaigns as a special frontier process of the Soviet period. The author characterizes virgin regions as a space of a unique inner frontier. The main prerequisite for the beginning of a large-scale development campaign was the presence, in the East of the country, of vast areas that were sparsely populated and almost unused. This study identifies Orenburg region as one of the largest regions that saw an attack on virgin land. As the virgin campaign unfolded, it began to face various kinds of problems and difficulties. In the process of plowing new land masses, the specifics of the regions in the immediate development zone were practically not taken into account. The use of standardized techniques had a negative impact on the development of the farms established on virgin land. Obvious mistakes were made in the course of organizing the production and social infrastructure. The article focuses on the difficult living and working conditions on virgin land in the first years. The development of new lands led to the formation of a unique virgin area. Its creation was preceded by a complex process. A virgin brotherhood emerged through the joint overcoming of many difficulties, in parallel with the development of virgin villages. At the initial stage, the territorial and informational isolation of the region contributed to the consolidation of the resettlement community. It is demonstrated that the virgin land gradually lost the features typical for frontier regions. Already by the mid-1960s, the zone of development of new lands in Orenburg region almost completely lost the inherent frontier specificity that it had at the beginning of the campaign.
Clinical evaluation for the transforaminal endoscopic hernia of the intervertebral disc of the lumbosacral spine with puncture nucleoplasty
Authors: Abakirov M. D , Al-Bawareed O. A , Mamyrbaev S. T , Panin M. A , Nurmukhametov R. M , Abdrakhmanov R. R , Alawaida W. , Ramulgon K. , Alenizi A. A
Published: August 2020

Transforaminal endoscopic hernia removal is currently one of the most effective and relatively safe methods of treating an intervertebral hernia of the lumbosacral spine. In the current study we aim to evaluate the effectiveness of transforaminal endoscopic discectomy in combination with puncture nucleoplasty as a surgical protocol to treat hernias of the lumbosacral spine. 87 patients (43 men and 44 women) aged 19 to 62 years were enrolled in our study and underwent proper evaluation. The duration of follow-up in the postoperative period averaged 18.7 6 months (from 7.2 to 28 months). To assess the clinical effectiveness of the performed surgical interventions, the dynamics of the pain syndrome was analyzed using a visual analogue scale (VAS). Patient status, pain and disability were assessed using Oswestry Disability Index (ODI). Postoperative complications were also analyzed to evaluate the results of the operation. Moreover, objective criteria were used to assess the level of pain and the degree of disability. All patients showed a decrease in pain intensity and an improvement in the vital signs. Long follow up for ODI within six months after the operation showed a significant decrease by two to three times. Due to the lack of similar studies (endoscopy plus nucleoplasty), the results of our work were compared with the results of endoscopic hernia removal without nucleoplasty. However, in the evaluated patients, some intra- and postoperative complications were observed. In conclusion, the use of puncture nucleoplasty as the second stage of minimally invasive hernia removal of muscle tension dysphonia (MTD) is an effective treatment method, significantly reducing the recurrence rate of the disease.
Advisable including glucosaminylmuramyldipeptide in Helicobacter pylori therapy: experience of ten-year investigation
Authors: Konorev M. R , Guryanova S. V , Tyshevich E. N , Pavlyukov R. A , Borisova O. Yu
Published: August 2020

Helicobacter pylori infection is a common bacterial infection in humans and is associated with peptic ulcer disease and chronic gastritis. The presence of natural resistance to some antibiotics in bacteria, as well as the appearance of primary and secondary resistance to antibacterial agents, complicates treatment and determines the search for new methods of therapy. The aim of this study was to evaluate the efficacy and safety of 10-year complex treatment of patients with duodenal ulcer associated with H.pylori , 136 patients (96 men, 40 women; mean age 45.8 14.8 years; 18-65 years). H.pylori was determined morphologically and by rapid urease test one day before the start of therapy, after 1, 6, 12 months, 2 years, 5 and 10 years. Patients of the first group received basic therapy: omeprazole 0.02 g 2 times a day, clarithromycin 0.5 g 2 times a day, amoxicillin 1 g 2 times a day, for 10 days (OCA group 1; n = 98). Patients of the second group, in addition to the basic therapy, took 1 mg per day drug Liсopid (group 2 OСAL; n = 38). At the 1st stage of the clinical study, 130 patients completed eradication therapy. Tracking completeness was 96 %. The frequency of H.pylori eradication after per protocol treatment: OCA - 83 % (95 % CI: 75 %-91 %), OCAL - 97 % (95 % confidence interval (CI): 92 %-100 %). The incidence of adverse reactions after treatment (per protocol): OCA - 26 % (95 % CI: 17-35 %; nausea; n = 24), discontinued treatment - 5 % (95 % CI: 0.8 %-10 %; diarrhea; n = 5); OCAL - 3 % (95 % CI: 0.01 %-8 %; nausea; n = 1), all were treated. Taking the drug Liсopid 1 mg (glucosaminyl muramyl dipeptide, JSC Peptek, Russia) as part of complex therapy contributed to the elimination of H.pylori and the absence of relapses for 2 years. Observation of patients in the next 5 and 10 years also showed the advantage of including the immunomodulator in therapy: a significant 15 % decrease in H.pylori reinfection (P 0.05), a 23 % decrease in the frequency of gastrointestinal adverse reactions (P0.01), compared with a 10-day standard triple regimen without immunomodulatory therapy with glucosaminylmuramyl dipeptide. When using several antibiotics in H.pylori eradication therapy, not only pathogenic, but also commensal microorganisms are destroyed, the waste products of which are vital and maintain immune homeostasis, including through the NOD2 receptors of innate immunity. The effectiveness of the complex therapy of H.pylori infection can be explained by the fact that the drug Liсopid compensates for the signal for innate immunity receptors that is missing due to the absence of commensals, providing an adequate immune response and preventing chronicity and recurrence of infection.
On the Theory of Entropy Solutions of Nonlinear Degenerate Parabolic Equations
Authors: Panov E. Yu.
Published: August 2020

We consider a second-order nonlinear degenerate parabolic equation in the case when the flux vector and the nonstrictly increasing diffusion function are merely continuous. In the case of zero diffusion, this equation degenerates into a first order quasilinear equation (conservation law). It is known that in the general case under consideration an entropy solution (in the sense of Kruzhkov-Carrillo) of the Cauchy problem can be non-unique. Therefore, it is important to study special entropy solutions of the Cauchy problem and to find additional conditions on the input data of the problem that are sufficient for uniqueness. In this paper, we obtain some new results in this direction. Namely, the existence of the largest and the smallest entropy solutions of the Cauchy problem is proved. With the help of this result, the uniqueness of the entropy solution with periodic initial data is established. More generally, the comparison principle is proved for entropy suband super-solutions, in the case when at least one of the initial functions is periodic. The obtained results are generalization of the results known for conservation laws to the parabolic case.
Resolvent Approximations in L2-Norm for Elliptic Operators Acting in a Perforated Space
Authors: Pastukhova S. E.
Published: August 2020

We study homogenization of a second-order elliptic differential operator Aε = - div a(x/ε)∇ acting in an ε-periodically perforated space, where ε is a small parameter. Coefficients of the operator Aε are measurable ε-periodic functions. The simplest case where coefficients of the operator are constant is also interesting for us. We find an approximation for the resolvent (Aε + 1)-1 with remainder term of order ε2 as ε → 0 in operator L2-norm on the perforated space. This approximation turns to be the sum of the resolvent (A0 + 1)-1 of the homogenized operator A0 = - div a0 ∇, a0 > 0 being a constant matrix, and some correcting operator εCε. The proof of this result is given by the modified method of the first approximation with the usage of the Steklov smoothing operator.
Russian English and what it is not
Authors: Rivlina Alexandra A.
Published: August 2020

The arguments against the Expanding Circle (EC) Englishes being varieties in their own right are often provoked by terminological inaccuracies both in professional and folk-linguistic debate. The aim of the article is to particularize the concept of Russian English by highlighting the differences between Russian English as an EC variety per se and a number of English-related forms and practices in Russian-based intranational communication, which also might be referred to as Russian English or Rus(s)lish/Runglish. The article discusses the notion of Ruslish in detail, drawing on the recent surveys of hybrid Englishes, or X-lishes in World Englishes theory. The study provides a qualitative analysis of a corpus of examples illustrating different conceptualizations of Ruslish and some of its major tokens. As a result, Ruslish in the narrow sense of the term, as the basilectal sub-variety of Russian English, is distinguished from Ruslish as a broader language-contact concept embracing various cases of English-Russian interaction, primarily the Englishization of Russian, which is closer to its folk metalinguistic interpretation. A special emphasis is placed on the cases of mock Russian English/Ruslish, a form of bilingual language play, a linguistic parody, when distinctive features of Russian English or Ruslish are exaggerated and ironically quoted in styling the Other. The article also follows the translanguaging approach to hybrid Englishes investigation and some emergent practices of translanguaging in written English-Russian interaction, specifically some cases of Roman-Cyrillic trans-scripting, or trancripting, are tentatively defined as new Ruslish.
English in the Russian-based recruitment discourse
Authors: Gritsenko Elena S. , Alikina Anastasia V.
Published: August 2020

The paper addresses the use of English in the Russian-based recruitment discourse. Language is viewed through the prism of the sociolinguistics of globalization and understood as a set of mobile trans-locally operative resources used to achieve specific goals of communication. The corpus for analysis includes job ads and rsums posted on the recruitment platforms HeadHunter and Super.Job, videotaped conversations of job seekers with recruiters and employers, and ethnographic interviews with recruitment professionals. We used discourse analysis, ethnographic methods, and quantitative measuring to analyze the data. The study consists of two stages. During the first stage, we found out that English can be used as the main language of recruitment or in the form of insertions in the Russian-based texts to demonstrate professionalism, position the company, and filter the candidates. The second stage revealed that the all-English segment of the Russian recruitment discourse has narrowed, while the use of English in truncated forms has increased. This dynamic is caused by the expansion of the digital segment of the Russian job market (social media, Internet channels), where English-mediated technologies are the main instrument of interaction with clients. It results in further hybridization and boosts translingualism in work-related settings. English, with its tendency to informal personified communication patterns, also affects the communicative conventions of the Russian-based recruitment discourse. The study demonstrates the growing role of English as an agent of global professional discourses and an intermediary between people and technologies.
METODE QIRĀ’AH DALAM PEMBELAJARAN KETERAMPILAN RESEPTIF BERBAHASA ARAB UNTUK PENDIDIKAN TINGKAT MENENGAH
Authors: Khoiriyah Hidayatul
Published: August 2020

This study aims to determine the implementation of the qirā’ah method in learning Arabic receptive skills for secondary education. The method used is a library research method, while data collection is done by examining and exploring several journal articles, books, and several data sources or other information that are considered relevant to the study. The results of this study are that learning using the    qirā’ah method is an alternative for teachers in teaching Arabic receptive skills (mahārah al-istimā’ and mahārah al-qirā’ah). In learning listening skills (mahārah al-istimā’) students are able to understand the contents of what has been listened to and reveal again through their language both orally and in writing. As for reading skills learning (mahārah al-qirā’ah) students are able to read Arabic texts fluently, are able to translate and are able to understand it well and fluently.
ANALISIS KUALITAS TES BAHASA ARAB BERBASIS HIGHER ORDER THINKING SKILL (HOTS)
Authors: Rahmi Nur Fauziah Indah , Syihabudin Syihabudin , Sopian Asep
Published: August 2020

Educational evaluation is an important aspect, because with educational evaluation, it can be known to what extent the educational process has been achieved, it can also determine the next step regarding what is to be done. In the realm of evaluation, analyzing the quality of HOTS-based tests is still rarely to be done as was the case in Lembang MTs Al-Musyawarah. Arabic Language Teachers have not analyzed the quality of Arabic question items in the final examination (UAS). This research aims to determine the quality of hots-based instruments in final examination (UAS) questions of Arabic that are have not yet know. The type of research that used in this research is descriptive research, and 30 people as the sample of data.  The results of this research show that the validity of the test be include high, and high reliability, 25 questions are not fit with the criteria for multiple choice writing, the level of difficulty not yet proporsional, distinguishing power enough, and effectiveness of deceivers are enough categories, and all questions include as Lots category with C1 numbers as much as 2 items, 2 items for C2, and C3 as much as 36 items of questions.
PEMAKAIAN USLUB AL-HAKIM DALAM ALQURAN
Authors: Nugraha Inggo
Published: August 2020

Artikel penelitian ini bertujuan untuk mendeskripsikan bentuk ungkapan Uslub al-hakim dalam Alquran. Uslub al-hakim adalah bentuk pengalihan pembicaraan kepada sesuatu yang lebih penting. Uslûb al-hakîm merupakan seni dalam ilmu balaghah karena memberikan kesan indah pada pembicaraan seseorang. Pembahasan mengenai Uslûb al-hakîm ini kurang diberikan tumpuan khusus oleh para ulama Balaghah juga para penulis kitab yang didalamnya membahas mengenai uslub al-hakim. Sumber data penelitian ini diambil dari Alquran. Objek penelitiannya terfokus pada ayat-ayat uslub al-hakim yang terdapat dalam Alquran. Adapun datanya dihimpun melalui dokumentasi dan format pencatatan. Kemudian datanya dianalisis secara kualitatif. Hasil penelitian menunjukan bahwa terdapat delapan puluh dua  ungkapan uslub al-hakim dalam Alquran. Ungkapan uslub al-hakim tersebut dapat diklasifikasikan ke dalam empat bentuk
Korelasi Antara Persepsi Siswa Terhadap Penerapan Model Non Directive Teaching Dengan Motivasi Belajar Bahasa Arab Di SMK Muhammadiyah Prambanan
Authors: Nurlaila Nurlaila
Published: August 2020

Model Pembelaaran non directive teaching merupakan salah satu model pengajaran personal yang didasarkan pada teori konseling karya Carl Rogers yang menyatakan bahwa hubungan positif antar sesama manusia memudahkan mereka untuk tumbuh. SMK Muhammadiyah Prambanan merupakan sekolah berbasis kejuruan, yang mana mayoritas siswanya merupakan remaja laki-laki. Selain problem linguistik (fonologi, morfologi, sintaksis, dan semantik) yang merupakan problem utama yang dihdapai oleh siswa, di sisi lain berdasarkan background keilmuan diminati siswa adalah keilmuan praktis (empiris) sehingga kecenderungan siswa untuk mempelajari ilmu-ilmu normatik-teoritik seperti bahasa Arab masih sangat minim. Oleh karena itu perlu adanya treatmen dan prilaku khusus untuk meningkatkan motivasi siswa dalam belajar bahasa Arab. Model non directive teaching dengan pendekatan personalnya membangun hubungan positif diharapak dapat diciptakan dengan membangun relasi yang baik antara guru dengan siswa atau siswa dengan siswa lainnya sehingga menciptakan dorongan untuk belajar. Penelitian ini bertujuan untuk mengetahui ada tidaknya korelasi antara persepsi siswa terhadap penerapan model non directive teaching dengan motivasi belajar bahasa Arab siswa. Penelitian ini adalah penelitian deskriptif  kuantitatif, dengan subjek penelitian siswa kelas XI SMK Muhammadiyah Prambanan yang diperoleh dengan random sampling. Pengumpulan data menggunakan metode angket, observasi, wawancara dan dokumentasi. Analisis data menggunakan statistik deskriptif dan inferensial melalui uji korelasi sederhana (product moment) dan uji regresi sederhana, yang sebelumnya  dilakukan uji normalitas dan uji linieritas. Hasil penelitian menunjukan terdapat hubungan dan pengaruh yang positif signifikan antara persepsi siswa terhadap penerapan model non directive teaching dengan motivasi belajar bahasa Arab siswa.
التأويل النحوي عند ابن جني في (الفَسْر ) شرح ابن جني الكبير على ديوان المتنبي
Authors: Al Adba'iy Abdol Ghaniy Syauqiy Musa , Bin 'Aly Musa Sa'ied Bin Muhammed
Published: August 2020

تهدف فكرة التأويل النحوي عامة في الفكر النحوي العربي إلى اتساق العلاقة بين النص والقاعدة والتوفيق بين أساليب اللغة والقواعد النحوية، وهذا البحث ( التأويل النحوي عند ابن جني)، في(الفسر ) شرح ابن جني الكبير على  ديوان المتنبي، يهدف إلى إظهار جهود ابن جني في التأسيس لظاهرة التأويل في النحو العربي، وبيان مظاهره ، والكشف عن مقاصده ، وقد اشتمل على بعض من مظاهر التأويل النحوي مثل: الحذف والزيادة والتضمين والحمل على المعنى.
Arterial Placement of Central Venous Catheters
Authors: Wierstra Benjamin , Au Selena , Cantle Paul , Rommens Kenton
Published: August 2020

Arterial misplacement of central venous catheters can often be avoided with the use of real-time ultrasound-guided procedural competency.  However, misplacement can still occur and is more likely to occur when the internal jugular vein is located directly above the common carotid injury.  The resultant injury to the common carotid artery occurs through the posterior wall of the internal jugular vein.  Arterial injury may also occur when the subclavian vein is attempted in a non-ultrasound-guided fashion.  Optimal management requires a coordinated evaluation of the catheter misplacement by Interventional Radiology and Vascular Surgery to ensure maximum patient safety during catheter removal.  This article reviews the literature around this topic and provides a summary of the best approach to safely remove the misplaced catheter.
Resume
Le mauvais positionnement artériel des cathéters veineux centraux peut souvent être évité grâce à l'utilisation de compétences procédurales guidées par ultrasons en temps réel.  Cependant, un mauvais positionnement peut toujours se produire et est plus susceptible de se produire lorsque la veine jugulaire interne est située directement au-dessus de la lésion carotidienne commune.  La lésion de l'artère carotide commune qui en résulte se produit à travers la paroi postérieure de la veine jugulaire interne.  Une lésion artérielle peut également se produire lorsque la veine sous-clavière n'est pas guidée par un ultrason.  Une gestion optimale nécessite une évaluation coordonnée du mauvais positionnement du cathéter par la radiologie interventionnelle et la chirurgie vasculaire afin de garantir une sécurité maximale au patient lors du retrait du cathéter.  Cet article passe en revue la littérature sur ce sujet et fournit un résumé de la meilleure approche pour retirer en toute sécurité le cathéter mal placé.
Board of directors, capital structure, investment decisions and firm-performance: An empirical study of Nordic firms
Authors: Hundal Shab , Eskola Anne
Published: August 2020

Firms’ financing, boards of directors’ characteristics, investments, and firm-performance (financial and non-financial) occupy a pivotal place in corporate finance and corporate governance literature. The current study explores if causalities between the abovementioned four distinct albeit inter-related phenomena follow any pattern. The data comprising of 1240 firm-years belonging to Finland, Norway, Sweden, and Denmark for the period of 2003 to 2018 have been analyzed by applying multivariate linear regression and principal component analysis. The findings show that the impact of boards of directors’ characteristics is stronger on capital structure, however, weaker on investments and financial performance. The major contribution of the article is creating a set orderly and sequential causalities between financing, boards of directors’ characteristics, investments, and firm-performance.
A novel kinetic cholinesterase-inhibition based method for quantification of biperiden in pharmaceutical preparations
Authors: Djuric Vladan , Mitic Violeta , Deletic Nebojsa , Ilic Marija , Cirkovic Bratislav , Stankov-Jovanovic Vesna
Published: August 2020

Biperiden, an antiparkinsonian anticholinergic drug, has been found to inhibit enzymatic hydrolysis of butyrylthiocholine iodide, which is catalyzed by serum cholinesterase. By measuring the difference in the basic and inhibitory hydrolysis reaction rates, in the presence of biperiden as an inhibitor, it is possible to develop a kinetic method for its determination. Both systems, enzyme-substrate-chromogen and enzyme-substrate-chromogen-inhibitor, were characterized by biochemical parameters (KM = 0.326 ? 0.330 mmol dm-3; Vmax = 40 - - 99 ?mol dm-3 min-1), while inhibition was defined as non-competitive with the constant of inhibition Ki = 6.142 ?mol dm-3. The reaction conditions have been optimized followed by determination of the calibration curve, the corresponding equation and the limits of detection and quantification yielding 3.84 and 12.80 nmol dm-3, respectively. Using the calibration chart, it is possible to determine biperiden in different samples in the concentration range of 0.035?35.940 ?mol dm-3. Influence of a number of substances, found in the sample, on the reaction rate was also examined. The optimized method was applied for determination of biperiden in pharmaceutical preparations. Accuracy of the method was tested using the standard addition method. The proposed method has good sensitivity, selectivity, it is simple and fast, and above all easily accessible, and thus applicable in biochemical and pharmaceutical laboratories.
On rheonomic nonholonomic deformations of the Euler equations proposed by Bilimovich
Authors: Borisov A.V. , Tsiganov A.V.
Published: August 2020

In 1913 A. D. Bilimovich observed that rheonomic constraints which are linear and homogeneous in generalized velocities are ideal. As a typical example, he considered rheonomic nonholonomic deformation of the Euler equations whose scleronomic version is equivalent to the nonholonomic Suslov system. For the Bilimovich system, equations of motion are reduced to quadrature, which is discussed in rheonomic and scleronomic cases.
Starting Your Career at an Accounting Firm: The Role of Personality in Explaining Career Starts
Authors: Kerckhofs Linde , Hardies Kris , Vandenhaute Marie-Laure , Ceustermans Stefanie
Published: August 2020

SYNOPSIS

We investigate whether personality traits affect graduate business students' decisions to start their career (1) in the accounting profession, and (2) at a Big 4 accounting firm. Survey data (n = 348) show that students with lower levels of openness to experience are more likely to seek careers in accounting. Further, students with higher levels of narcissism are more likely to start their careers in a Big 4 firm. Additionally, the effect of narcissism on students' decisions to seek careers at Big 4 firms is fully mediated by their attitudes toward the Big 4. Compared to students who seek careers at non-Big 4 firms, Big 4 career seekers believe that the Big 4 offer higher salaries, better opportunities for training, experience, and networking, more advancement opportunities, better career prospects, more interesting, challenging, and fulfilling work, more friendly colleagues, a better relationship with supervisors, more job security, and higher prestige.
Aplikasi Filling Rekam Medis Menggunakan Metode Algoritma Turbo Boyer Moore
Authors: Harzani Beni , Diana Diana
Published: August 2020

Nagaswidak Health Center is one of the community health centers that is quite large and has complete facilities. But the problem that is often faced by officers in the puskesmas is the medical record data processing system which is still manual, causing the accumulation of patient medical record file data, in addition to patients who have been checked before and lost their medical records, it is very difficult for officers to find back, so the officer made a new medical record data. To overcome this problem, a Medical Records Filling Application was made at the Nagaswidak Health Center which includes the processing of medical records, patient data, drug data, action data, doctor data, and admin logins. So that the data search problem is not difficult, the turbo boyer moore algorithm method is applied which is expected to later be able to facilitate the search for patient data in the medical record filling application. Based on the test results Boyer Moore's Algorithm successfully applied to search for the beginning of a word, middle word, and final word. And the level of ease and usefulness of medical records application using Boyer Moore's algorithm obtained results that the level of ease is 80% and 100% usability rate.
Kombinasi Metode ISOMAP Dan KNN Pada Image Processing Untuk Pengenalan Wajah
Authors: Kosasih Rifki
Published: August 2020

Wajah manusia memiliki ciri khusus yang dapat membedakan dengan orang lainnya sehingga pengenalan wajah sangat penting dilakukan untuk mengenali seseorang. Ciri khusus pada wajah ini disebut juga dengan fitur. Pada penelitian ini, untuk mendapatkan fitur dilakukan pengenalan pola citra wajah dengan menggunakan metode isomap. Metode isomap merupakan salah satu metode dari manifold learning yang menghasilkan fitur-fitur dengan cara mereduksi dimensi. Citra wajah yang digunakan dalam penelitian ini terdiri dari 6 orang dengan tiap orang memiliki 4 citra wajah dengan ekspresi yang berbeda-beda. Data citra ini dibagi menjadi dua bagian yaitu data latih dan data uji. Selanjutnya data citra tersebut diubah menjadi vektor. Metode isomap digunakan untuk mentransformasikan vektor tersebut menjadi vektor yang mengandung fitur wajah. Setelah fitur wajah diperoleh, selanjutnya dilakukan pengujian pada data uji dengan menggunakan algoritma K Nearest Neighbor (KNN).  Algoritma K Nearest Neighbor digunakan untuk pengklasifikasian dengan cara mencari K data latih yang terdekat dengan data uji. Dari hasil klasifikasi diperoleh bahwa tingkat akurasi sebesar 83,33%.