bluuebunny/crossref_metadata_2025 huggingface dataset:
DYNAMICS OF ALTERATIONS IN WHITE BLOOD CELL AND SEPSIS-ASSOCIATED HUMORAL FACTORS DURING SULFUR MUSTARD INTOXICATION
Authors: Sidorov Sergey , Sergeev Anatolij , Zhakovko Ekaterina , Chepur Sergey , Kuzmin Andrey , Shefer Timur , Alekseeva Alexandra
Published: January 2025

Introduction. Sulfur mustard (SM) is an important chemical warfare agent. Lack of antidote and pathogenetic means in the arsenal of modern medicine for the treatment of SM poisoning requires further studies on the pathogenesis and development of protective medical devices and treatment schemes. The aim is to assess the features of immune response and intestinal bacterial translocation during SM intoxication. Materials and methods. The experiments were performed with Chinchilla male rabbits. SM was injected to laboratory animals intramuscularly at a dose of 63mg/kg, amounting to 1.0 LD84. The test materials presented by blood samples collected by cardiac puncture and from the lateral ear vein. Cardiac blood was used to produce serum and subsequently to determine the level of the sepsis-associated humoral factors (lipopolysaccharide, sCD14, procalcitonin, tumor necrosis factor a, interleukins 6 and 10) by using enzyme-linked immunosorbent assay. Results. In the peripheral blood of rabbits there were found changes characterized by decreased total leukocyte count, a development of lymphocytopenia and monocytopenia, as well as two-phase granulocyte count dynamics. The blood leukocyte formula showed the most significant changes related to three cell subsets: segmentonuclear neutrophils, lymphocytes and plasmocytes. The analysis of blood serum for assessing level of the sepsis-associated humoral factors showed that the earliest pathobiochemical change was related to higher sCD14. On day 2 post-exposure, a simultaneous increase in the levels of tumor necrosis factor a, interleukins 6 and 10 was reported. The cytokine level was decreasing to baseline range starting from day 3 onwards, whereas the clinical manifestation of SM intoxication was increasing and reaching the maximum magnitude. The analysis of blood serum for lipopolysaccharide level showed its increase on day 3 and 4 post-exposure. Conclusion. The study data in the context of the proposed interpretation, allow to highlight the following phasing of pathological changes during an extremely severe SM intoxication: day 1 - myeloid phagocytic system activation and hyperphagocytosis; day 2 - systemic inflammatory and compensatory anti-inflammatory response syndromes; days 3-4 - «immune paralysis», intensified bacterial translocation, depletion of the endotoxin-binding system and «endotoxin aggression».
Using the state-space separable cohort model modification for assessment of Pacific cod Gadus macrocephalus (Gadidae) stocks in the Petropavlovsk-Komandorskaya subzone
Authors: Terentyev D. A. , Ilin O. I.
Published: January 2025

Results of using a state-space cohort model with smoothing unscented Kalman filter for assessment of Pacific cod stock abundance and the other population parameters in the Petropavlovsk-Komandorskaya Subzone are presented. Series of numerical experiments were carried out with various variants of the recruitment model. The results of the work performed can be used in preparing forecasts of the TAC of marine commercial fish in terms that the observational data allow the use of age-structured models in the state space.
Freshwater turtle (Reptilia: Testudines) assemblage from an urban protected Atlantic Forest remnant: population density, movement and habitat preference
Authors: Rocha Sabine B. , Rouco Carlos , Grou Carlos Eduardo V. , Ferreira Vanda Lúcia
Published: January 2025

ABSTRACT Urbanization may significantly impact wild population dynamics, even in protected green spaces. From 2016 to 2018, we accessed an assemblage of freshwater turtles isolated in an urban remnant of the Atlantic Forest, southern Brazil. We captured turtles by active search, hookless fishing, and funnel trap, and we marked them individually. Using a capture-mark-recapture method, we estimated population density, and movement, including home range size and habitat selection. Home ranges were estimated using the 100% minimum convex polygon method and habitat selections through eigenanalysis. We captured 41 specimens of Phrynops geoffroanus (Schweigger, 1812), 35 Trachemys dorbigni (Duméril & Bibron, 1835), and 20 Trachemys scripta elegans (Wied-Neuwied, 1839). The invasive T. dorbigni showed the highest density (1.72 individual/ha), followed by the native P. geoffroanus (1.36 individual/ha) and the invasive T. scripta elegans (0.87 individual/ha). Home range sizes for P. geoffroanus and T. dorbigni ranged between 0.04-0.48 ha, with the latter species covering the longest distance (525.8 m). All three species showed a preference for habitats influenced by human presence (walkways). Our findings highlight the anthropic influence on the movement of the freshwater turtle assemblage and underscore the need for enhanced protection of native species and control of invasive turtles. This study provides essential baseline data for future researches and management of urban areas.
Thermo-mechanical behaviour of energy pile considering non-uniform initial ground temperatures
Authors: Zhuang Pei-Zhi , Wang Kang-Xu , Song Xiu-Guang , Geng Xueyu , Yang He
Published: January 2025

Ground temperature varies along the vertical direction at shallow depths, and its influences on the thermo-mechanical response of energy piles during heating and cooling processes remain unclear so far. The aim of this paper is to fill this gap by performing finite-element numerical analysis based on Comsol Multiphysics software, taking energy piles in the Yellow River flooded area as an example. A three-dimensional numerical model is established and is then validated by comparison with published experimental results. Parametric analyses are conducted with a focus on the heat exchange efficiency, temperature distribution, displacement and axial stress of energy piles caused by heating in summer and cooling in winter. It is found that the ignorance of ground temperature variation could lead to: (a) overestimation of the heat exchange efficiency in both winter and summer; (b) underestimation of pile head displacement in summer and overestimation in winter; (c) overestimation of the axial stress in summer and underestimation in winter.
Enhancing fretting performance of 316L biomedical alloys through duplex TiN and DLC coatings
Authors: Khan Thawhid , Taufiqurrakhman Mohamad , Merrell Charlotte , Pryce Greg , Danturthi Atreya , Liskiewicz Tomasz , Pandit Hemant , Yan Yu , Bryant Mike
Published: January 2025

This study investigates the use of duplex coatings, TiN/diamond-like-carbon (DLC), on improving the tribological performance of stainless steel 316L which is commonly used for femoral stems in total hip replacement implants. A range of substrate pre-treatment variants (nitriding and polishing) were applied to investigate the impact on the mechanical and tribological performance of the coatings. The tribological performance of plasma vapour deposition duplex coating variants was tested using a bespoke in-house fretting tribometer with an electrodynamic shaker utilising a ball-on-plate configuration. Fretting was replicated by applying micro-motion to the Ø12 Al2O3 ball relative to duplex coated SS 316L plates under a dead weight normal load. Un-polished substrates prior to the coating deposition led to improved tribological performance likely due to improve coating adhesion to the substrate surface. The hydrogenated DLC sample variants showed lower friction performance compared to hydrogen-free DLC variants most likely due to higher amounts of graphitisation.
Impacto del Impuesto a la Salida de Divisas en startups de comercio electrónico
Authors:   Universidad Politécnica Salesiana, Rodríguez Meca Madeleine , Olivos Cadena Jorge ,   Universidad Politécnica Salesiana, Ecuador, León Barzallo Félix ,   Universidad Politécnica Salesiana, Ecuador
Published: January 2025

El Impuesto a la Salida de Divisas (ISD) es un tributo que se aplica sobre el valor de las operaciones y transacciones monetarias que se realicen al exterior (Fuentes y Morales, 2019). El ISD en Ecuador, implementado desde 2007 con el objetivo de mantener las divisas dentro del país y consolidar una economía dolarizada, ha generado diversas problemáticas para distintos sectores económicos (Pesantez Cedeño et al., 2021).
SIMILARITY OF SEA URCHIN (ECHINODERMATA: ECHINOIDEA) FAUNA OF RUSSIAN SEAS
Authors:   Kamchatka Branch of Pacific Geographical Institute of FEB RAS, Stepanov V.G. , Panina E.G. ,   Zoological Institute of Russian Academy of Sciences
Published: January 2025

A comparative analysis of the sea urchins fauna from Russian seas was carried out based using known published references and personal data by these authors. We analyzed the species diversity of sea urchins from the Arctic seas of Russia (White Sea, Barents Sea, Kara Sea, Laptev Sea, East-Siberian Sea, and Chukchi Sea), Far Eastern seas (Bering Sea, Sea of Okhotsk, Japan Sea) and the Central Polar Basin. In these areas, the sea urchins fauna can be clearly divided into 2 groups: 1) Arctic seas, 2) Far Eastern seas. Among the Far Eastern seas, the fauna from the Sea of Okhotsk and Japan Sea is most similar. Among the Arctic seas, the fauna of the Barents Sea is most different. Therefore, 2 groups can be distinguished: 1) Kara Sea, Laptev Sea and Central Polar Basin, 2) White Sea, East-Siberian Sea and Chukchi Sea.
INCREASE OF STOMACH NEMATODE, SOBOLIPHYME BATURINI, INFECTION IN SABLE AND ERMINE AS ONE OF THE RESULTS OF AMERICAN MINK ACCLIMATIZATION IN KAMCHATKA
Authors:   Kamchatka Branch of Pacific Geographical Institute of FEB RAS, Tranbenkova N.A.
Published: January 2025

The host and biogeographic characteristics of the hemipopulation of the stomach nematode Soboliphyme baturini, Petrow, 1930 in the Kamchatka Peninsula are considered. The archival (1952–1979) and our own (1980–2024) materials of commercial predators helminthological monitoring were analyzed. It was proved that one of the reasons for increasing infestation of the Kamchatka subspecies of sable with this nematode is the introduction of the American mink in the 70s of the last century, who became an obligate host of S. baturini and increased the flow of its invasive origin and infection probability of other predatory species. Using the example of sable and ermine, the relationship of their invasiveness indicators with the phases of the acclimatization process of the American mink is shown. Before mink settling the average S. baturini invasion extensity in sable on the southeastern coast of the peninsula was (34.89 ± 7.81)%, after – (44.26 ± 4.8)%. This figure increased from (60.56 ± 6.94)% (1966–1981) to (83.05 ± 8.89)% (2012–2023) on the southwestern coast.
Sistemas dinámicos en contexto: Modelación matemática, simulación, estimación y control con MATLAB
Authors:   Universidad EAFIT, Vélez Carlos
Published: January 2025

El objetivo general de este libro es identificar, enlazar y aplicar los principales conceptos, métodos matemáticos y herramientas de los sistemas dinámicos, la teoría de la estimación y los sistemas de control en diversas áreas del conocimiento (sistemas en contexto). Esto se logra con la determinación de las características del sistema de manera matemática en problemas sencillos, y computacionalmente, con ayuda de MATLAB y Simulink, en problemas más complejos. Entre las estrategias metodológicas del libro están: el énfasis en una visión sistémica de los temas y los problemas, la aplicación de métodos no lineales con un enfoque desde los sistemas no lineales, la solución de problemas y la verificación de resultados con MATLAB, el énfasis en los conceptos y los métodos de áreas afines (investigación, ciencia, pensamiento sistémico, matemáticas, educación), el enfoque basado en competencias de aprendizaje, casos de estudio de diversa naturaleza (no solamente físicos) en los que se aplican e integran todos los temas vistos en el libro, ejercicios resueltos y propuestos, prácticas tipo proyecto con MATLAB, y otros recursos en el sitio web del libro (https://siscontexto.blogspot.com)
«Принцип материальности» в эпистемологии компьютерных симуляций
Authors: Волошин Михаил Юрьевич
Published: January 2025

В области эпистемологии компьютерных симуляций существует аргументативная стратегия, получившая название «принцип материальности» (Х. Дюран). Стратегия состоит в том, чтобы приписывать компьютерным симуляциям в науке эпистемические характеристики того или иного уровня на основе их онтологического сходства (степени «материальности») с материальными экспериментами. Это сопоставление отчасти мотивировано языковыми интуициями: компьютерное моделирование часто именуют «вычислительным экспериментом» и т.п. Если это верно, то компьютерные симуляции следует рассматривать как подвид научного моделирования и приписывать им соответствующее промежуточное положение между теоретическим и экспериментальным уровнем научного знания (как это делается в рамках современных подходов к структуре научного знания, а именно семантического и прагматического). Рассматриваются четыре варианта реализации «принципа материальности», аргументирующие как в пользу достоверности компьютерных симуляций, так и против нее. Компьютерные симуляции размывают границы между материальным и виртуальным (вычислительным) экспериментированием. «Принцип материальности» может работать аргументом как в пользу, так и против этого различения. Приводятся и усиливаются два основных аргумента против принципа материальности, условно называемые «аргумент непрозрачности» и «аргумент множественной реализуемости». Показано, что принцип материальности недостаточен для того, чтобы аргументированно обосновать эпистемологический статус компьютерных симуляций.
A Broken World. Some Notes on Manuel Sacristán as a Reader of Ortega
Authors: Гарридо Анксо Фернандес
Published: January 2025

By reconstructing the reading of Mission of the University found in The University and the Division of Labor, we will carry out a critical juxtaposition between the views of José Ortega y Gasset and Manuel Sacristán, emphasizing the critical notes made by the latter, using as a guiding thread the issue of the division of labor, which is implicit in Ortega's text. In the second stage of our discussion, we will seek to clarify how and to what extent Ortega's text influences Sacristán's conception of dialectics.
Uniting Action and Thought, Journalism and Philosophy in the Chase of Cultural Renovation
Authors: Саиз Санз Селия
Published: January 2025

Review of: Blanco Alfonso, I. 2023. Nací sobre una rotativa. Las empresas culturales de José Ortega y Gasset [in Spanish]. Madrid: Tecnos.
The Main Narratives of a Search for Truth
Authors: Вальдивия Террасас Джудит Николь
Published: January 2025

Review of: Zamora Bonilla, J. 2022. Ortega y Gasset: la aventura de la verdad [in Spanish]. Barcelona: Shackleton Books.
Ortega's New Philology
Authors: Балагуэр Гарсия Эсмеральда
Published: January 2025

This article delves into the philological theory of the Spanish philosopher José Ortega y Gasset, which he himself termed “new philology”. His proposal for philological reform, seen as a necessary precursor to the resurgence of a new philosophy — one that in his thought would be the philosophy of vital and historical reason, — centers around the problematics of “saying authentically” and silencing. These two components of speech are only clarified and revitalized considering two factors: the biographical intentionality of the speaker and the vital, historical, and circumstantial context. This article aims to reconstruct the “biographical archaeology of saying authentically and silencing” present in Ortega's philosophy.
The Essential Liberalism of José Ortega y Gasset
Authors: Ласага Медина Хосе
Published: January 2025

In “The Essential Liberalism of José Ortega y Gasset,” the author explores Ortega's philosophy of liberalism, which emphasizes the radical reality of individual life as the basis of freedom and society. Unlike doctrinal liberalism or the liberal traditions of the 19th century, Ortega's concept is rooted in his philosophy of “vital reason,” which posits life as a dynamic, self-creating process within historical circumstances. He argues that liberalism should enable personal life to flourish by providing freedom from oppressive state control and fostering a pluralistic society. Ortega critiques mass society, where individuality is often subsumed under collective ideologies, whether totalitarian or democratic. His liberalism prioritizes civil society over state power and champions the moral responsibility of minorities to lead through example, not coercion. While skeptical of the naïve optimism of 19th century liberalism, Ortega insists on preserving its essential principles, as liberalism underpins Europe's historical destiny. He distinguishes democracy from liberalism, cautioning against the tyranny of majority rule without safeguards for individual freedom. In his later works, Ortega stresses the importance of constructing Europe as a supranational entity to overcome nationalist tensions, preserving the pluralistic and free spirit that defines European civilization.
Efficient production ofhydrogel-based transparent soil v1
Authors: Sotta Naoyuki
Published: January 2025

This protocol illustrates semi-automated production of hydrogel-based "transparent soil" for plant or bacterial research. It utilizes cassette tube pump to control liquid flow and water levels to achieve stable spherification, resulting in higher yield with less labor.
Quantifying and Checking Genomic DNA v2
Authors: Carlos Goller Carlos , Sjogren Carly
Published: January 2025

Overview and Goals Your bacterial isolate has been grown on agar plates and lysed open, and genomic DNA has been isolated for sequencing. Next, we need to quantify our DNA yield and assess its integrity. We will use the IMPLEN nano spectrophotometer and Qubit to measure our DNA quantity. We will also use an Agilent TapeStation electrophoresis system to assess the size of the DNA quality. Learning Objectives After completing this lab, you will gain the following lab skills: Lab safety and proper personal protective equipment (PPE) Proper use of a nano spectrophotometer and Qubit fluorometer to analyze DNA samples. DNA concentration and integrity analysis using absorbance, fluorescence, and gel electrophoresis.
AI-Supported Participatory Workshops: Middle-Out Engagement for Crisis Events
Authors: Tomitsch Martin , Fredericks Joel , Hoggenmüller Marius , Crosby Alexandra , Wong Adrian , Yu Xinyan , Huang Weidong
Published: January 2025

Considering the lived experience of communities is key when making decisions in complex scenarios, such as preparing for and responding to crisis events. The article reports on three participatory workshops, which assigned community representative roles to workshop participants. Using role-playing as a method, participants were given the task of collaborating on making a decision relating to a speculative crisis scenario. Across the workshops, we collected data about simulating a middle-out engagement approach and the role of artificial intelligence (AI) in enhancing collaboration, supporting decision-making, and representing non-human actors. The article makes three contributions to participatory planning and design in the context of the UN Sustainable Development Goals. First, it presents insights about the use of AI in enhancing collaboration and decision-making in crisis event situations. Second, it discusses approaches for bringing more-than-human considerations into participatory planning and design. Third, it reflects on the value of role-playing as a way to simulate a middle-out engagement process, whereby actors from the top and the bottom collaborate towards making informed decisions in complex scenarios. Drawing on the findings from the workshops, the article critically reflects on challenges and risks associated with using AI in participatory workshops and collaborative decision-making.
Use of camrelizumab in treatment of nasopharyngeal carcinoma
Authors: Alymov Yu. V. , Mudunov A. M. , Romanov I. S. , Pkheshkhova B. G.
Published: January 2025

Nasopharyngeal carcinoma is a rare pathology. It develops in the nasopharyngeal mucosa and is characterized by aggressive (recurrent and metastatic) progression. Due to complicated location, this disease is often diagnosed at late stages and requires systemic therapy. Due to the rareness of nasopharyngeal carcinoma, until recently there were no studies on modern drug therapy of this pathology with high evidence level.

Aim. To describe the capabilities and mechanism of action of camrelizumab in nasopharyngeal carcinoma. The results of studies investigating the mechanism of action of camrelizumab were analyzed. The effectiveness of this drug in progression of nasopharyngeal cancer with previous chemotherapy and in combination with chemotherapy as the 1st line treatment of recurrent and / or metastatic process was evaluated. Based on the phase II trial results, the use of camrelizumab in patients with disease progression during standard chemotherapy allows to achieve progression-free survival of 8.5 months. Data obtained in the phase III trial demonstrated clinical benefit of adding this drug to standard chemotherapy in the 1st line therapy of recurrent and / or metastatic nasopharyngeal carcinoma: median progressionfree survival significantly increased from 6.9 to 9.7 months.

Therefore, camrelizumab is a modern highly effective immunotherapeutic drug designed to treat patients with nasopharyngeal carcinoma.
Selpercatinib – a new option for a precision approach to the treatment of medullary thyroid cancer
Authors: Plugar A. K. , Severskaya N. V. , Isaev P. A. , Panaseykin Yu. A. , Polkin V. V. , Vatina L. N. , Agababyan T. A. , Ivanov S. А. , Kaprin A. D.
Published: January 2025

Introduction. Multikinase inhibitors are used to treat nonresectable locally advanced and/or metastatic medullary thyroid cancer (MTC). However  they are characterized by high toxicity associated with kinase inhibition. Selective RET inhibitor selpercatinib demonstrates high selectivity and tolerance which makes it a promising agent for MTC treatment.

Aim. To evaluate selpercatinib effectiveness and tolerance in patients with metastatic MTC associated with a mutation in the RET gene.

Materials and methods. The study included 9 patients with metastatic MTC and mutation in the RET gene who received treatment with selpercatinib 160 mg 2 times a day. The drug effectiveness was evaluated every 2–3 months based on the results of multispiral computed tomography of the whole body and tumor marker (calcitonin and carcinoembryonic antigen) levels.

Results. Median duration of therapy was 29 months  overall response rate was 78 %; complete response was observed in 56 % of patients. After 12 months of therapy  progression-free survival was 100 %; after 24 months  it was 89 %. Persistent decrease in calcitonin level (by more than 90 %) was achieved in all patients. The most common adverse events were arterial hypertension and insignificant creatinine increase.

Conclusion. The results of therapy show significant improvement in the rate of objective response and progression[1]free survival which makes selpercatinib a preferential treatment choice in this category of patients.
ASSESSING COVID-19 SPREAD AND VACCINATION EFFECTIVENESS IN CHAD THROUGH MEAN KERNEL DENSITY ESTIMATION
Authors: Issaka Mahamat Ali , Yaya Yaya Youssouf
Published: January 2025

This study introduces an innovative approach to assess the impact of COVID-19 vaccination on the spread of the virus in Chad by employing mean kernel density (MKD) estimation for non-parametric analysis. Utilizing epidemiological data collected between January 2021 and June 2023, we explore the correlation between vaccination rates and confirmed cases across various regions of Chad. Our analysis demonstrates that the application of MKD provides a smoother and more accurate visualization of infection trends before and after vaccination campaigns. The results reveal a significant reduction in confirmed cases post-vaccination, particularly in areas with higher vaccination rates. Correlation analysis further highlights the effectiveness of vaccination campaigns, showing a strong association between vaccination rates and the decrease in infections. However, the data also suggest a reactive vaccination strategy in regions with initially high infection rates. This innovative application of mean KDE provides new insights into the dynamics of vaccination efforts and their crucial role in reducing the spread of COVID-19 in Chad.
NATIONAL POLICY OF CARE VERSUS THE INFORMAL CAREGIVER STATUTE: A CASE STUDY ON PUBLIC CARE POLICIES IN PORTUGAL AND BRAZIL
Authors: Uchôa Marcela , Van Vossole Jonas
Published: January 2025

This article takes a critical approach to recent developments in care policies in Portugal and Brazil, focusing on statutory and legislative changes aimed at addressing care work and its socioeconomic implications. The article focuses on two case studies: Portugal’s Informal Caregiver Statute, which intends to legally recognize and support informal caregivers but has limitations, such as restrictive definitions, inadequate implementation, and perpetuation of gender roles, effectively privatizing care within the family unit. Brazil’s approach, which although still in the legislative stages, on the other hand, aims to create an equitable and more advanced care policy, promoting a collective approach, a balanced division of labour, and addressing gender, racial, and territorial inequalities. In a call for recognition, fair compensation, and support for caregivers, we emphasize the need for collective responsibility and public care policies. Inspired by Marxist feminism and Social Reproduction Theory, we end by discussing the crisis of care, affirming the emotional and social tensions of balancing family and work within capitalism. It highlights how essential – albeit often unpaid – social reproduction work, predominantly performed by women, is for society.
Research Insights: Do Enforcement Spillovers Boost the Effectiveness of Disability Employment Quotas?
Authors: Berlinski Samuel , Gagete-Miranda Jessica
Published: January 2025

Enforcing disability employment quotas through inspections and fines increases hiring of persons with disabilities by about 7 percent. Compared to direct fines, enforcement spillovers through firm networks can have up to twice the impact on disability employment. Targeted enforcement strategies can amplify policy effectiveness beyond directly affected firms even in economies with low compliance.
Characterization, application and action mechanism of bioactive peptides (BAPs) derived from microbes, plants and recombinant proteins against food borne pathogens; a review
Authors: Nabgan Milad , Shariatifar Nabi
Published: January 2025

The preventive properties of bioactive peptides (BAPs) derived from microbes and plants have stimulated extensive research and discovery. The antimicrobial properties of BAPs against foodborne pathogens have made them effective and potential alternatives to existing antibiotics. Antitumor, antihypertensive, antioxidant, anti-obesity, and antidiabetic activities are just a few of the other beneficial properties of BAPs. An increasing number of harmful microorganisms, including foodborne pathogens, are developing resistance to various antibiotics. The goal of scientific research is to discover new, innovative and safe antimicrobial agents to fight these infections. Foodborne pathogens are among the many pathogenic microorganisms against which plant and microbial BAPs have shown significant antimicrobial activity. These compounds (BAPs) have the ability to eliminate pathogenic microorganisms by disrupting membrane integrity, inhibiting DNA and RNA synthesis, preventing protein synthesis, blocking protein activity or interacting with specific intracellular targets. In addition, the beneficial effect of BAP consumption includes the regulation of intestinal microbiota and modulation of the balance of reactive oxygen species in the digestive tract. This review article deals with different sources of antipathogen peptides, the food application of peptides from distinct sources, and their Mechanism of action.
The Comparison of the Effectiveness of Child-Centered Mindfulness Therapy and the Role of Acceptance and Commitment Therapy on Emotional-Cognitive Empathy of Students with Attention Deficit Hyperactivity Disorder Experiencing Bullying in Isfahan
Authors: Khodadad Farzaneh , Manshaee Gholamreza , Torka Hajar
Published: January 2025

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is considered a serious problem in educational environments and has significant negative impacts on the psychological well-being of students. The present study aimed to compare the effectiveness of child-centered mindfulness therapy and acceptance and commitment therapy on emotional-cognitive empathy of primary school students with ADHD experiencing bullying.
Methods: This semi-experimental study was conducted in 2023 using a pre-test and post-test design with a control group and a two-month follow-up over a six-month period in Isfahan city. A purposive sampling method was employed, and 54 boy students aged 9-11 years meeting the inclusion criteria were randomly assigned to three groups of 18 participants including child-centered mindfulness therapy (N=18), acceptance and commitment therapy (N=18), and a control group (N=18). Data were collected using the child and adolescent empathy questionnaire. Participants in the first group received child-centered mindfulness therapy in 10 60-minute sessions, conducted twice a week, while participants in the second experimental group received acceptance and commitment therapy in 9 60-minute sessions, conducted twice a week. By the end of the study, 15 participants remained in each group. Data analysis was performed using repeated measures ANOVA and Bonferroni post-hoc tests, utilizing SPSS software version 26.
Results: The results indicated that both child-centered mindfulness therapy and acceptance and commitment therapy were effective in enhancing emotional empathy (p<0/05) and cognitive empathy (p<0/05).This effectiveness was also maintained at the follow-up stage (p< 0/05). However, no significant differences were observed between the effectiveness of the interventions (p>0/05).
Conclusion: The results of this study indicated that both child-centered mindfulness therapy and acceptance and commitment therapy significantly affected emotional and cognitive empathy in students with ADHD and can be utilized by therapists.
A Curriculum Design for Integration of NetSuite ERP with Data Analytics and Computer Technologies
Authors: Tulli Sai krishna Chaitanya
Published: January 2025

The changes in the last few years in the ERP systems and the increased importance of analytical and computerised systems mean that there is a significant need for educational frameworks to address the future complexities of business environments for students. This study recommends that asynchronous NetSuite ERP be integrated with data analytics and computer technologies in the development of the curriculum to expose learners to the real-world concepts. The curriculum is structured around four core modules: Navigating ERP using NetSuite, integration of analytical data, application of computing technologies for ERP, and a project implementing skills learned with actual cases. A strong methodological approach enables the study to include the needs assessment, curriculum development, pilot testing and evaluation stages. In fact, experience from pilot testing shows increased appreciation of ERP processes among students, enhanced use of analytics tools, and application of programming to ERP alterations. Participants’ qualitative feedback about the curriculum demonstrates its applicability and usefulness for closing learning–practice gap. Thus, this work develops the discussion concerning interdisciplinary education by describing the model of ERP systems’ implementation, data analysis, and computer technologies, including improvements applicable to various institutions. The introduced curriculum not only makes students more valuable in the competitive job market but also prepares them to solve modern organizational problems.
Regularized Water Uses profiles in an Area of Intense Agricultural Productionin the Headwaters of the Pantanal in Mato Grosso (MT)
Authors: Pascotto Lorena Moreira Nichochelli , Kuriki Mikaele Silva , Santos Francisco Lledo dos , Lázaro Wilkinson Lopes , Arrolho Solange
Published: January 2025

The granting rights to use water resources is one of the instruments that aims to promote the quantitative and qualitative control of the same, as well as the right of access to this essential element for the life and maintenance of ecosystems. Thework was developed with the objective of identifying the regularized uses in the municipality of Campo Novo do Parecis and its interface with the use and occupation of the municipality 's soil. Based on the analysis of grants and registration of insignificantfunding in the municipality, between the years of 2012 to 2019. The results show that irrigation stands out as the largest water user, accounting for 79.64% of the annual volume, followed by industry with 7.8% and urban supply with 6.05%. Thus, it is possible to perceive the need for more effective actions directed to the management of water resources in order to ensure water in quality and quantity adequate to the uses of the current and future generation.
Implementation of parcels of land micro-reservoirs as a strategy to reduce water volume in galleries and peak flows in the micro-drainage system of a new subdivision
Authors: Kempka Mariane , Ribeiro Rodrigo Scoczynski , Bosse Rúbia Mara , Martins Marcella Scoczynski Ribeiro , Rubio Monica Rodrigues Brisolla
Published: January 2025

Urbanization has caused significant environmental impacts on natural cycles, particularly the hydrological cycle. Soil impermeabilization increases surface runoff, contributing to the higher frequency and intensity of urban flooding. This phenomenon underscores the growing vulnerability of cities to extreme events, which are further exacerbated by climate change. Precipitation patterns have been shifting due to climate alterations, necessitating adaptations to IDF curves, which are critical for planning climate adaptation strategies. In many cases, existing drainage systems are insufficient to handle the impacts of urbanization and intense rainfall events. In this context, the adoption of techniques that control flow distribution over time and mitigate peak flows may be crucial for flood control, especially in urbanized areas. Green infrastructure techniques, such as Low Impact Development (LID) practices, have proven effective in mitigating urban flooding. Among these measures, infiltration techniques such as green roofs and permeable pavements, as well as storage techniques such as retention basins, detention basins and rain barrels (RB), stand out. This study examines the impact of implementing RB in the microdrainage system of a new subdivision in the interior of Paraná. The simulations were conducted for return time of 1, 5, and 10 years, indicating potential failures in the drainage system. To prevent flooding, the strategic inclusion of RB was proposed to mitigate peak flows in the drainage galleries, preventing overflow and system overload, and reducing peak flow by up to 47%.
Environmental remediation of canga and iron mining waste pile using bee pasture of Baccharis dracunculifolia
Authors: Paiva Anna Syria Aranha , Peixoto Ricardo André Fiorotti , Moura Sandra Aparecida Lima de
Published: January 2025

Mining is an economic activity known for its significant potential to generate socio-environmental impacts. In the case of iron ore mining in the Iron Quadrangle of Minas Gerais, the areas most frequently affected are typically ferruginous fields, due to vegetation suppression for pit opening and the deposition of waste rocks. Owing to their unique characteristics, these regions exhibit a high degree of endemism, with species adapted to the specific environmental conditions, making them suitable candidates for use in ecological restoration projects. Baccharis dracunculifolia is a native plant with significant potential for inclusion in such projects due to its ability to colonize degraded areas and its interactions with pollinators, such as the honeybee Apis mellifera. Consequently, environmental restoration efforts can be integrated with apicultural production, providing a sustainable alternative for the productive use of previously degraded land. The objective of this research is to identify and compare the physical and chemical properties of soils from iron mining waste piles and canga for potential use in environmental restoration with B. dracunculifolia as a bee pasture. Analyses included particle size distribution, bulk density, moisture content, pH, and chemical composition using X-ray fluorescence (XRF). Results indicated that both environments demonstrated similar properties across all tests, supporting the use of native plants such as B. dracunculifolia in ecological restoration projects. Furthermore, the establishment of bee pastures composed of this species in degraded areas can help diversify the income streams of local communities near mining operations, thereby reducing their dependency on mining activities.
Environmental Research focused on Environmental Strategies
Authors: Poleto Cristiano , Senhuk Ana Paula Mila dos Santos , Gaydeczka Beatriz
Published: January 2025

This special issue of the Revista Brasileira de Ciência, Tecnologia e Inovação (RBCTI) brings thirteen unpublished papers, which deal with different approaches related to environmental studies, carried out in many states of Brazil. These are studies developed by professors and post-graduate students of different institutions.
THE RELEVANCE OF MEHDI HAIRI YAZDI'S EPISTIMOLOGY WITH THE TRADITION OF BOARDING-BASED HIGHER EDUCATION AT THE PESANTREN ZAINUL HASAN GENGGONG
Authors: Fatimah Nur , Soleh Achmad Khudori
Published: January 2025

Mehdi Hairi Yazdi is a prominent modern philosopher who sought to revive Islamic philosophy by integrating it with Western thought. Drawing on Suhrawardi’s philosophy of illumination, Mehdi explored its alignment with Western philosophical concepts. A key contribution of his thought to modern Islamic philosophy is the concept of Hudhuri science, an epistemology based on intuition and reason. This research examines the relevance of Mehdi’s epistemology to the Pesantren-based higher education tradition at Pesantren Zainul Hasan. Employing a qualitative method with content analysis, the study explores the relationship between Mehdi’s epistemology and the Pesantren’s educational practices. Findings indicate that the Pesantren Zainul Hasan tradition emphasizes critical reasoning, religious practices, and the pursuit of spiritual blessings, forming the foundation of its higher education epistemology. Both the Pesantren’s approach and Hudhuri epistemology share commonalities in acquiring knowledge through Sufistic and rational paths.
HARMONY AND FRICTION: THE POPULARITY OF SHALAWAT BADAR AMONG SANTRI
Authors: Mashad Dhurorudin , Ghafur Muhammad Fakhry
Published: January 2025

Shalawat Badar is verses composition in Arabic that is dedicated to the Prophet Muhammad. The verses in this verse contain elements of Islamic political ideology. It was composed during a period of significant political upheaval, specifically the era of Guided Democracy (Demokrasi Terpimpin). During this period, Muslims in Indonesia experienced profound political unrest, largely attributable to the growing hegemony of the Indonesian Communist Party (PKI). The present study seeks to contribute to the existing scholarship on Shalawat Badar by offering an analysis of its contemporary spread and popularity. Despite the theological critiques levelled by modern Santri regarding its theological content, which is often seen as bid'ah, Shalawat Badar has witnessed a notable proliferation, defying the obstacles often associated with the dissemination of such works. The findings of this study suggest that Shalawat Badar has gained a widespread presence among Santri from diverse sub-cultures, performed by individuals across various contexts. This paper utilizes a qualitative method, employing a descriptive-analytical approach augmented by literature studies and in-depth interviews with multiple sources, to address the various aspects of Shalawat Badar that are frequently criticized yet still held in various parts of Indonesian.
DIGITAL SUFISM: THE TRANSFORMATION OF PIETY IN GUS ULIL'S ONLINE TEACHINGS
Authors: Hakim Putri Rahmah Nur , Sampurno Margo Teguh , Abdullah Irwan , Kailani Najib , Larasati Yuniar Galuh
Published: January 2025

The transformation of da'wah from offline to online is an important issue that needs to be studied in the context of the development of digital technology and changing patterns of social interaction in the modern era. While some previous studies have discussed the impact of digitalisation on religious practice, there is a gap in understanding how social media platforms such as Facebook change the dynamics of da'wah, especially in the context of recitations led by scholars such as Gus Ulil. The focus of this study is to examine how the digitalisation of da'wah affects the spiritual interactions between ulama and their followers, and how these changes affect the meaning and experience of religiosity in the digital era. This study is qualitative in nature with a focus on online recitations on Facebook, where data was collected through participatory observation, content analysis, and in-depth interviews. The data analysis process was conducted through the stages of coding, categorisation, and interpretation to understand the patterns of interaction and the impact of online dakwah. The key findings of this study show that digitalisation not only expands the reach of da'wah, but also changes the structure of religious communities to become more private and exclusive. Recommendations from this study include the development of more inclusive policies to support the sustainability of digital da'wah, as well as methodological approaches that can be used to improve the sustainability of digital da'wah.
An analysis of fetoinfantile losses in the Komi Republic
Authors: Naumova K. M. , Andreeva L. S. , Sannikov A. L. , Ryabokon I. I.
Published: January 2025

Background. The preservation of maternal and child health is an important component of health care. 2024 by Decree of the President of the Russian Federation dated 22.11.2023 No. 875 was declared the year of the family. The current negative dynamics of demographic processes in modern society raises the problem of ensuring a high level of survival and health of newborns. This issue carries importance both at the state level as a whole and at the strategic level to maintain the population size both at the federal level and in each of its regions, including the Komi Republic. In the conditions of the demographic crisis, not only in the Komi Republic, but also in the Russian Federation, the analysis of fetoinfantile losses plays an important role. The population living in the regions of the Far North and areas equated to them is subjected to a complex of extreme natural and climatic factors, which negatively affects the reproductive health of the population, causing fetoinfantile losses. The presented work describes the indicators of fetoinfantile losses in the Komi Republic in comparison with similar indicators in the Russian Federation as a whole. Objective. Conduct a comparative analysis of infant mortality rates, perinatal mortality dynamics, early neonatal and stillbirth rates from 2012 to 2022, thereby characterizing fetoinfantile losses in the Komi Republic. Design and methods. The analysis of fetoinfantile losses was carried out on the basis of data presented in the unified interdepartmental information and statistical system, the Federal State Statistics Service, statistical collections of GBUZ RK “RIAC” Basic Indicators of Population Health and Health Status of the Komi Republic for 2012–2022, State Report “On the State of Health of the Population of the Komi Republic in 2022”. A trend line was used to evaluate and illustrate trends. Results. Fetoinfantile losses in the Komi Republic tend to decrease, but exceed the average for the Russian Federation. Congenital abnormalities, deformities and chromosomal disorders continue to occupy a leading place in the structure of infant mortality in the Komi Republic. In the Komi Republic, the trend towards a decrease in the abortion rate remains, but 1.5 times higher than this figure in the Russian Federation. Conclusion. In the Komi Republic, there is a complex of behavioral, climatic and social factors that affect reproductive health, leading to fetoinfantile losses exceeding average indicators. There is a need to optimize the examination of women in the pre-gravidar and antenatal period, including medical genetic counseling, which will reduce stillbirth and the incidence of congenital malformations.
Laboratory animals anesthesia recommendations for biomedical research purposes
Authors: Ryzhkov I. A. , Vasyutina M. L. , Dolgikh V. T. , Kazemirchuk M. S. , Kuzovlev A. N. , Murashova L. A. , Balabanova K. M. , Silachev D. N. , Soloveva V. V. , Sedko V. A. , Kornyushenkov E. A.
Published: January 2025

Anesthesia is widely used in experimental biomedical research to anesthetize and immobilize laboratory animals during surgical interventions and experimental procedures. In contrast to clinical and veterinary anesthesiology, an important aspect of anesthesia in laboratory animals is to minimize the effect of anesthetics on the results of the study. On November 19, 2022, the IV Scientific and Practical Conference “Experimental Surgery, Anesthesiology and Reanimatology of Laboratory Animals” was held in Moscow, where the community of specialists in the field of laboratory animal science, experimental surgery, pathophysiology, veterinary medicine, clinical and veterinary anesthesiology discussed various aspects of anesthesia in laboratory animals. This review is based on the conference proceedings and is devoted to general issues of animal anesthesia, its technological aspects (methods, equipment and consumables), consideration of advantages and disadvantages of the most commonly used inhalation and injection anesthetics.

The advantages and schemes of modern combined anesthesia are substantiated, in particular, the need for adequate intraoperative analgesia and the possibility of regional anesthesia. The use of obsolete and non-recommended drugs is also discussed. The review and recommendations have a practical orientation and are intended for biomedical researchers who use laboratory animals in basic, translational and regulated preclinical studies.
International experience in the application of horizon scanning systems for identifying innovative health technologies
Authors: Omelyanovskiy V. V. , Mukhortova P. A. , Zinadinov S. I. , Slabikova A. A. , Krekhtunova L. O. , Rukavitsyna N. P. , Ryagina V. A. , Kingshott A. A. , Teptsova T. S. , Bogdanova V. O.
Published: January 2025

The implementation of innovative medical technologies into healthcare practice can significantly prolong and improve the quality of life of the population. However, successful integration of these technologies into the healthcare system requires a systematic approach to finding and evaluating innovations. Such evaluation should take place at different stages — development, registration planning and pre-market release — and consider the wider implications of these innovations for medical practice. The purpose of this review is to describe the underlying principles of leading international horizon scanning systems, using examples from Singapore, Canada, England, France, England, the Netherlands, Italy, Sweden, and the USA. In addition, the review aims to identify general trends in the development of these systems and explore their potential applicability to the healthcare system of the Russian Federation.