bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus)
Authors: Ozawa Sarah M. , Guzman David Sanchez-Migallon , Hawkins Michelle G. , Diao Stephanie M. , Masri Acacia E. , Gunther-Harrington Catherine T. , Knych Heather K.
Published: January 2022

OBJECTIVE

To determine the pharmacokinetics and potential adverse effects of pimobendan after oral administration in New Zealand White rabbits (Ocytolagus cuniculi).

ANIMALS

10 adult sexually intact (5 males and 5 females) rabbits.

PROCEDURES

2 pilot studies were performed with a pimobendan suspension or oral tablets. Eight rabbits received 7.5 mg of pimobendan (mean 2.08 mg/kg) suspended in a critical care feeding formula. Plasma concentrations of pimobendan and O-demethylpimobendan (ODMP) were measured, and pharmacokinetic parameters were calculated for pimobendan by noncompartmental analysis. Body weight, food and water consumption, mentation, urine, and fecal output were monitored.

RESULTS

Mean ± SD maximum concentration following pimobendan administration was 15.7 ± 7.54 ng/mL and was detected at 2.79 ± 1.25 hours. The half-life was 3.54 ± 1.32 hours. Plasma concentrations of pimobendan were detectable for up to 24 hours. The active metabolite, ODMP, was detected in rabbits for 24 to 36 hours. An adverse event occurred following administration of pimobendan in tablet form in 1 pilot study, resulting in death secondary to aspiration. No other adverse events occurred.

CLINICAL RELEVANCE

Plasma concentrations of pimobendan were lower than previously reported for dogs and cats, despite administration of higher doses, and had longer time to maximum concentration and half-life. Based on this study, 2 mg/kg of pimobendan in a critical care feeding formulation should maintain above a target plasma concentration for 12 to 24 hours. However, further studies evaluating multiple-dose administration as well as pharmacodynamic studies and clinical trials in rabbits with congestive heart failure are needed to determine accurate dose and frequency recommendations.
Критическая теория: этапы идейного развития
Authors: Тютченко Д. А
Published: January 2022

Тютченко Д. А.  Критическая теория: этапы идейного развития. В данной работе дан исторический обзор формирования критической теории, её общих принципов и этапов развития. На примере теории культуры Франкфуртской школы, критической семиотики Ролана Барта, концепции власти Мишеля Фуко, постколониальной теории и постмарксизма рассматривается спектр понятий и подходов, а также методологическая и теоретическая эволюция критической теории. Ключевые слова: критическая теория, кризис, постколониальная теория, субалтерн, идентичность, марксизм
Контроль над грузами во Владивостоке в контексте политической борьбы летом 1918 г.
Authors: Беляева  Н. А.
Published: January 2022

Беляева Н. А.  Контроль над грузами во Владивостоке в контексте политической борьбы летом 1918 г. На основе документов Российского государственного исторического архива Дальнего Востока (РГИА ДВ) рассматривается ситуация, сложившаяся во Владивостоке летом 1918 г. Попытка Приморской областной земской управы взять под контроль использование грузов во Владивостоке в краткий период междувластия (после свержения власти Советов и установления власти Колчака) вылилась в её противостояние с таможней. На основе архивных документов исследуется подоплека конфликта. Он рассматривается как отражение политической борьбы и личного противостояния. Ключевые слова: Владивосток, политическая борьба, использование грузов, Приморская областная земская управа, таможенный инспектор, таможня
Салехардская научно-исследовательская ветеринарная оленеводческая станция в 1940–1945 гг.
Authors: Рябкова О. В
Published: January 2022

Рябкова О. В.  Салехардская научно-исследовательская ветеринарная оленеводческая станция в 1940–1945 гг.. Исследование охватывает период с 1940 по 1945 гг. включительно и посвящено истории функционирования Салехардской научной-исследовательской ветеринарной станции по изучению болезней северных оленей Народного комиссариата земледелия СССР – первого научного учреждения Ямало-Ненецкого округа. В качестве исторических источников использованы документы, сохранившиеся в государственном архиве Ямало-Ненецкого автономного округа. В статье рассматриваются вопросы организации научной деятельности учреждения, направления работы научных сотрудников и их квалификация, определено из каких источников формировался бюджет станции. Основной задачей учреждения являлось научное сопровождение развития оленеводства в регионе. Сотрудники станции ежегодно проводили исследования в области прикладной экспериментальной ветеринарии в области оленеводства, разрабатывали методические рекомендации проведения противоэпизоотических мероприятий в колхозных, совхозных и личных оленьих стадах. Ключевые слова: Великая Отечественная война, Ямал, Ямало-Ненецкий автономный округ, наука, олени, ветеринария, Салехардская научно-исследовательская станция
Two case reports of umbilical metastasis: the enigmatic Sister Mary Joseph nodule
Authors: Ramael Maaike , Poels Helene , Steelandt Hilde Van , Develter Wim , Ramael Marc
Published: January 2022

Background:

Umbilical metastasis, also known as Sister Mary Joseph nodule, is a rare pathognomonic clinical sign suggesting the presence of an internal cancer.

Case Presentation:

We describe two female patients with Sister Mary Joseph nodule. In one case, there was a relapse of cancer. In the other patient, the Sister Mary Joseph nodule was the first and only clinical sign of an abdominal malignancy. We will briefly discuss the association with various internal malignancies as well as the pathogenesis and differential diagnosis.

Conclusion:

We conclude that Sister Mary Joseph nodule is a sign of intra-abdominal malignancy most frequently associated with gastro-intestinal or gynecological cancer.

It can be the first and only clinical sign of abdominal malignancy in an otherwise healthy appearing patient or it can be an indication of oncological progressive disease, tumor relapse.

Umbilical lesions should raise suspicion of a Sister Mary Joseph nodule, but a differential diagnosis must be made with other primary umbilical malignancies as well as with benign conditions involving the umbilicus.
DIAGNOSTIC ROLE OF MORPHOMETRIC ASSESSMENT OF TUMORASSOCIATED STROMA COMPONENTS OF SEROUS OVARIAN CARCINOMAS IN THE PROGNOSIS OF TUMOR PROGRESSION
Authors:   Khanty-Mansiysk State Medical Academy, Votintsev Alexei Alexandrovich
Published: January 2022

The method of computer morphometry of stroma components and evaluation of stromal-parenchymal relationships in the primary tumor node of serous ovarian cancer was used. A high potential for malignancy of tumor tissue, characterized by the resumption of tumor growth after radical treatment, is observed with the predominance of the epithelial component over the stroma, with a small number of necrosis in the tumor node, low density of microcirculatory vessels in the tumor, and the predominance of fi broblastic elements in the cellular microenvironment of the tumorassociated stroma.
BIOFILMS: STRUCTURE AND ROLE IN INFECTIOUS PATHOLOGY
Authors:   Khanty-Mansiysk State Medical Academy, Aliev Alim Maratovich , Sokolova Tatiana Nikolaevna , Petrovskaya Yulia Amanzholovna , Leonov Vadim Vyacheslavovich
Published: January 2022

Biofi lms are a way of persistence of microorganisms to the environment and the human body, at present they are of great interest to researchers, one of the reasons for this is considered to be the special properties inherent in biofi lms, an example of which is their increased resistance to adverse factors, including antibiotics, given that antibiotics are the main defense against bacteria, this poses a serious threat to humanity as a whole. Therefore, the study of the ability of microorganisms to form biofi lms is an important area in modern science and medicine, since mankind needs to learn how to deal with this phenomenon. In the presented study, we tried to briefl y reveal the essence of biofi lm formation, thereby making our contribution to the study of this problem
Efecto del azufre y Saccharomyces cerevisiae en la dieta de vacas lecheras como repelente de garrapatas en la comunidad El Regadío-Estelí, 2019
Authors: Moreno Castellón Medardo De Jesús
Published: January 2022

El presente trabajo se llevó a cabo en la comunidad el Regadío - Estelí, donde se evaluó el efecto del azufre y la levadura de cerveza (Saccharomyces cerevisiae) en la dieta de vacas lecheras como repelente de garrapatas, siendo las variables de estudio, identificación de garrapatas, efectividad de los tratamientos, producción lechera y relación beneficio/costo. Para el estudio se utilizó un diseño de bloque completamente al azar (BCA), el estudio estuvo constituido por tres tratamientos (T1: Testigo, T2: 8% de inclusión de azufre, T3: inclusión de levadura de cerveza) con tres repeticiones cada uno para un total de nueve unidades experimentales. Los resultados obtenidos fueron: Las garrapatas que estaban con mayor presencia dentro del hato lechero fueron los géneros Amblyomma cajennense en un 70% y Boophilus microplus con un 30%. La efectividad del azufre sobre la repelencia de garrapatas en los animales en estudio fue del 96%, mostrando diferencia significativa en comparación con el tratamiento a base de levadura de cerveza y el tratamiento testigo. En el caso de la variable producción lechera no existió diferencia significativa entre los tratamientos evaluados sin mostrar repercusión sobre la producción; sin embargo luego de realizar los análisis de rentabilidad, el suministro de azufre en la dieta de vacas lecheras tuvo un costo  de 0.8 córdobas día/animal, reduciendo gastos en control de garrapatas en comparación con otras prácticas de manejo de garrapatas; por lo tanto el suministro de azufre en la dieta es una alternativa viable para el control de garrapatas en vacas lecheras sin afectar su productividad.
Evaluación de dos métodos de sincronización de estro e inseminación artificial transcervical en capra aegagrus hircus, Estelí 2020
Authors: Landero Amaya Jaime Antonio , Carrasco Ruiz Paola Marcela
Published: January 2022

La presente investigación se realizó en la Universidad Católica del Trópico Seco, ubicada en Estelí, Nicaragua. El objetivo fue evaluar dos métodos de sincronización de estro con dispositivos hormonales CIDR nuevos y reutilizados, para inseminación artificial transcervical en cabras (Capra aegagrus hircus). Se utilizó un diseño cuasi experimental comparativo. Dentro de los tratamientos utilizados están: T1 sincronización de estro con dispositivos hormonales CIDR nuevos para la inseminación artificial con semen fresco, T2 con CIDR reutilizados para la inseminación artificial. En la variable Efectividad de los métodos de sincronización de estro, se aplicó una prueba T de Student, donde los resultados obtenidos no tuvieron diferencias estadísticas. En la variable porcentaje de preñez, no se presentó diferencia estadística. En la variable beneficio/costo el T1 resalta la confiabilidad en el componente rentabilidad obteniendo un 1.04 con el análisis RCB. Los resultados del análisis de la variable: Propuesta de plan de manejo reproductivo en UCATSE, se concluye que se deben reestablecer ámbitos de manejo nutricional y de instalaciones para la implementación en la reproducción caprina utilizando los métodos de sincronización del estro e inseminación artificial, para la obtención del incremento en la producción caprina.
Editorial
Authors: Baldiris Navarro Silvia
Published: January 2022

El segundo semestre del año 2021, vislumbra la finalización de la pandemia debida al COVID-19.  Por esta razón, desde el editorial queremos alentar a toda la comunidad académica a perseverar y contribuir a los procesos que permitirán que la humanidad avance en el cierre de este ciclo natural.
Proponer la propia pedagogía: reto sugestivo para los maestros
Authors: Juliao Vargas Carlos Germán
Published: January 2022

Se pretende responder a la cuestión: ¿qué se entiende por pedagogía y quién es pedagogo/a? desde la perspectiva de que todo maestro genera una “teoría practica” como fruto de su quehacer educativo, pero que definir ese saber transferible que solo los maestros producen requiere un ejercicio reflexivo y crítico que no siempre sabemos realizar. Se insta a que todo maestro desentrañe su teoría implícita, para revelarla, objetivarla, comprenderla, transformarla y transferirla si es el caso.
El papel de los jóvenes en las ciudadanías alternas: un ejercicio de participación ambiental en contextos socioculturales diversos colombianos
Authors: Quintero Ferrer Catalina , Cardona Alarcón Lorena , Negrete Doria Romelia del Carmen
Published: January 2022

Este artículo de investigación identifica la forma cómo los jóvenes colombianos pertenecientes a contextos socioculturales diversos de las regiones Caribe y Andina. Los participantes de la investigación, reconocen las principales problemáticas ambientales y se reconocen como actores en la toma de decisiones frente a la dimensión ambiental. Lo anterior es abordado desde el significado y las dinámicas de las ciudadanías alternas ejercida entre los jóvenes desde la dimensión ambiental y la participación en toma de decisiones en sus territorios, por medio del activismo en espacios de formación o diálogo de saberes. La metodología es de corte cualitativo, con apoyo en grupos focales que cuentan con la participación de 32 jóvenes entre 14 y 25 años, estudiantes de básica media y educación superior. Los resultados se presentan a partir del análisis de las percepciones ambientales entre los jóvenes y el reconocimiento de las acciones de la población como agentes políticos en la toma de decisiones.  De este modo, se visualiza el papel protagónico que asumen los jóvenes, con el interés en reconocer y apropiar los elementos biofísicos, sociales y políticos dentro de sus territorios, de manera que se conviertan en agentes transformadores a través de la acción y la participación.
Resignificación del pensamiento de Paulo Freire en la praxis pedagógica
Authors: Cruz Jerez Vicente Iván
Published: January 2022

El 19 de septiembre de 2021 se conmemoró el primer centenatrio del natalicio de uno de los pedagogos y filósofos de la educación más influyentes del siglo XX. Este acontecimiento desató una serie de eventos académicos y culturales a nivel mundial en los medios de comunicación, organizaciones populares, instituciones educativas y docentes, con el propósito de exaltar la memoria y el trabajo del gran maestro latinoamericano por su significativo aporte al desarrollo de la educación Popular que pretende la liberación de los oprimidos.

Para la Escuela Popular Claretiana (EPC), conocida también como Filodehambre y  Programa Formación Complementaria (PFC) de la Escuela Normal Superior  de Neiva (ENSN),  resultaba imposible no vincularse a la celebración de tan magno evento, porque éstas dos experiencias vienen implementando los principios filosóficos, pedagógicos y metodológicos  de Paulo Freire en su praxis educativa, tratando decantar una propuesta pedagógica liberadora con pertinencia rural, urbana marginal y para la inclusión. Esta es la razón principal para socializar los aspectos sobresalientes de la praxis educativa que ponen en evidencia el pensamiento pedagógico libertario freireano, impactando, de este modo en la vida de los niños, niñas y jóvenes de los sectores populares de Neiva y departamento del Huila, que acuden a éstas dos escuelas, buscando ser valorados y reconocidos como sujetos sociales.
Implementasi Cloud Based Video Conference System Menggunakan Amazon Web Service
Authors: Alanda Alde , Satria Deni
Published: January 2022

Since December 2019, the world and Indonesia have fought a major disaster, namely the Covid-19 virus pandemic. With the rapid spread or transmission of the virus, the Indonesian government decided to impose social distancing or social restrictions that impacted the education sector. Students and lecturers cannot conduct lectures face-to-face in class or laboratory, but lectures must be conducted online. For that, we need an open-source system developed by the campus in carrying out online courses. This application was developed using cloud technology and JITSI as an open-source video-conferencing application. In this study, testing of the features that exist in video conferencing and resource usage on the server is carried out. The results of feature testing on the application run as expected with several important features used for learning such as chat, share screen, recording features that can run optimally. The result tested the system resources based on the number of participants, 31 participants with an average use of 2.1GB RAM and 78 participants with an average RAM usage of 2.8GB.
Information Technology (IT) Users in Tertiary Education Institutions in Bulawayo, Zimbabwe: Case of Security Awareness
Authors: Ngwenya Bongani , Pelser Theuns
Published: January 2022

Information Technology (IT) expansion exposes organisations in developing countries to IT security risks. Zimbabwe’s tertiary education institutions (TEIs) are not spared. Every year, cyber-attacks increase and become more sophisticated, resulting in losses of personal and financial data for individuals, organisations and governments. As the world is interconnected, small and big organisations share the same internet platform. Therefore, IT security risks that affect one, affect all. When IT users are unaware of the risks and uninformed of ways to protect their IT systems, they remain vulnerable. Like other organisations in Zimbabwe, TEIs are vulnerable to cyber-attacks. The study that directed this article employed a quantitative methodological approach in the collection of the data and its analysis. A sample of 261 respondents was selected from the population of IT users in TEIs in Bulawayo. The results indicated that IT security awareness of IT users in TEIs in Bulawayo is low. This is evidenced by the low IT drivers’ contribution towards building IT users’ security awareness, and inadequate implementation and utilisation of IT security awareness tools. The prevailing phenomenon exposes TEIs in Bulawayo to a high risk of cyber-attacks. The results indicated a positive and significant correlation between IT security drivers’ contribution and IT security awareness tools utilisation in TEIs in Bulawayo. The implication is that an increase in IT security drivers’ contribution and IT security awareness tools utilisation will lead to increased IT security awareness. The study recommends that IT drivers double their contribution towards building IT security awareness through adequate implementation and utilisation of IT security awareness tools. This will safeguard the information that tertiary education institutions generate.
MODIFICATION OF COMPARATIVE REFERENCES IN UKRAINIAN POETRY OF THE TWENTIETH CENTURY
Authors: Shumeyko Olena
Published: January 2022

The article is devoted to the problem of studying the modification of linguistic means of phraseological units, namely comparative references, indicated by the author's individuality in Ukrainian poetry. Transformation undergoes different in origin and stylistic color comparative appeals. The most widespread transformations of comparative returns have been identified and characterized, and the peculiarity of such a change is the author's desire to increase the expressiveness of the language, including the creation of comic effect through various linguistic means. The objects of the comparisons under study are distinguished by thematic diversity. The semantics of the comparative reference itself or the contractual comparative part does not contain irony. The comic effect only arises when the comparison with the context, with the subject of comparison. In the field of critical appraisal and, as a result, irony, people, their demeanor, behavior, character, and activity fall. Animals, humans, biblical characters, etc. are the objects of comparative aphorisms. The originality and diversity of Neddy Nezhdan's individually-authorial comparisons mark the poet's moral and ethical appraisal, reflecting her lyrical heroine's attitude to men's perceptions, their ironic appraisal of relationships with them.
USE OF GOOGLE CLASSROOM SERVICE IN FORMATION OF FUTURE ENGLISG TEACHERS’ FOREIGN LANGUAGE COMMUNICATIVE COMPETENCE
Authors: Lysak Halyna
Published: January 2022

The article features the formation of foreign language communicative competence using Google Classroom service. The basic approaches to the definition of the concept of foreign language communicative competence have been analyzed. In order to optimize the process of formation of foreign language communicative competence of future foreign language teachers, it is necessary to introduce certain innovative forms and methods of teaching to provide students with a complex of linguistic knowledge and skills. Modern media technologies, in particular cloud technologies, are significantly used for realization of this task. The main peculiarities of cloud technologies using in the educational process have been considered. The author points out Google as the most common cloud-based service system used in the educational process in Ukrainian higher educational institutions. The advantages of using the Google Classroom platform (simplicity, time-saving, convenience, accessibility and security) in the process of learning a foreign language have been described. The great attention is given to the possibilities of using this service in the process of foreign language communicative competence formation. It is stated that the use of Google services in the educational process not only promotes the formation of foreign language communicative competence, but also significantly improves and diversifies the teacher’ teaching methods and activates the students’ creativity.
SYSTEMATIZATION OF HOLOPHRASTIC CONSTRUCTIONS’ PROPERTIES
Authors: Kalyta Alla , Klymenyuk Vladyslava
Published: January 2022

The paper is focused on studying regularities of holophrastic constructions’ functioning in the English literary prose by means of identifying and classifying the most significant features of their linguistic characteristics and expression. Holophrastic construction is regarded in the paper as a synthetically formed composite lexical unit that combines features of a word, a word-combination, or a sentence, and which figuratively but precisely represents in communication the integrative pictures of the individuals’ thinking or behavior, fixed in their memory as a corresponding concept, for decoding of which the recipients use their communicative and cognitive experience. Having analyzed the interpretations of holophrastic constructions’ characteristic features given in various scientific sources, the authors present a generalized classification of their linguistic properties as well as provide examples of their actualization in English literary texts. The carried out analysis allowed the authors to systematize English holophrastic constructions according to the following most significant features of their linguistic expression: communicative and pragmatic aim (inducing to actions, restraining form actions, and evaluation of the communicative situation), form of expressing meaning (transparent or opaque), degree of their emotional loading (emotionally neutral, emotionally coloured, and emotionally expressive constructions), their syntactic function in the sentence (subject, predicate, object, attribute, or adverbial modifier) and their structure (three-component, four-component, five-component, and poly-component, i.e. consisting of six or more components). The performed study advances the idea that the substantiated classification can serve as a methodological tool for structuring classes, subclasses and groups of the experimental material within the scope of similar linguistic research.
Адміністративно-юрисдикційна діяльність органів Служби безпеки України
Authors: Благодарний Андрій , Романов Микола , Стрельбицький Микола , Стрельбицька Лілія , Суслін Сергій
Published: January 2022

У посібнику комплексно висвітлено теорію та практику правового регулювання адміністративно-юрисдикційної діяльності органів СБ України. Визначено правовий статус органів СБ України, як суб’єктів адміністративноюрисдикційної діяльності, охарактеризовано функції та принципи зазначеної діяльності, запропоновано класифікацію та розкрито особливості адміністративно-юрисдикційних проваджень, що здійснюються органами державної безпеки. Видання адресоване науковцям, викладачам і студентам спеціальності «національна безпека», юридичних факультетів, працівникам органів публічної влади.
Development and Implementation of an Individualized Turning Program for Pressure Injury Prevention Using Sensor Technology in Nursing Homes: A Quality Improvement Program
Authors: Maguire Jeanine , Hastings Denine , Adams Mary , Phillips Debra , McKenna John , Lin Jiunn-Ru , Cooley Annemari
Published: January 2022

BACKGROUND: Turning nursing home residents every 2 hours has been a long-held standard for pressure injury (PrI) prevention in individuals with mobility impairments although evidence to substantiate this practice is limited. New guidelines recommend personalizing turning schedules to support person-centered care but lack specific recommendations about which turning frequencies are appropriate for various risk levels. PURPOSE: This quality improvement program aimed to determine the feasibility and outcomes of using individualized turn schedules for newly admitted nursing home residents. METHODS: An expert panel of wound clinicians developed, tested, and implemented a turn frequency tool that allowed staff in 2 nursing homes to select a turning schedule of 1, 2, 3, or 4 hours based on resident risk factors. Turning schedules were operationalized using a wearable sensor-based visual cueing technology that alerted staff to resident repositioning needs. Nonparticipating resident data were collected for comparison of PrI incidence. Descriptive statistics were calculated for all covariates. Significance of differences tests were performed as appropriate. RESULTS: Over 7 months, 154 residents had their turn period individualized, with 56% qualifying for 3-hour (Q3H) or 4-hour (Q4H) schedules. Facility-acquired PrI incidence was 94% lower in participants than in nonparticipants (P < .0001). Use of 3-hour and 4-hour intervals saved roughly 21 and 35 minutes of staff time, respectively, per resident per shift. CONCLUSION: Individualizing turning schedules is feasible. Residents with longer turning intervals did not develop PrIs, supporting previous studies about safely extending turning periods for most residents.
Relationship Between Caregiver Attendance at Wound Clinic Visits and Wound Healing in Patients With Diabetes: A Retrospective Multicenter Evaluation
Authors: Jessee Carol
Published: January 2022

BACKGROUND: Lower extremity wounds in patients with diabetes are significant and burdensome. PURPOSE: To evaluate retrospectively the correlation between lower limb wound outcomes in patients with diabetes and the presence of a caregiver during clinic visits. METHODS: The study was conducted in 3 outpatient wound centers in North Carolina. Patients (N = 85) were categorized into 2 groups: those who were accompanied by a caregiver at 50% or more of their visits to the wound clinic (n = 30) and those accompanied by a caregiver at fewer than 50% of their visits (n = 55). Data were evaluated using descriptive statistics and 2 sample t-tests. RESULTS: Although significant findings between the 2 groups were seen in age, race, Visit Count, Weeks in Service, Accompanied Count, and percentage of visits accompanied, the strongest meaningful correlation was in the Accompanied group between Percent Accompanied and Visit Count. In this group, the number of accompanied visits was 7.47 (range [standard deviation], 1–23 [5.2]) and the percentage was 87% (range [standard deviation], 52–100 [15]). This was stastically significant and with a moderately negative correlation (P = .04; r = -0.38). CONCLUSION: Despite negative predictors of healing, those who were accompanied by a caregiver at 50% or more of their visits demonstrated a higher healing rate and a lower number of total visits than those who were accompanied by a caregiver at fewer than 50% of their visits.
Efficacy and Safety of a Hyaluronic Acid–Containing Cream in the Treatment of Chronic, Venous, or Mixed-Origin Leg Ulcers: A Prospective, Multicenter Randomized Controlled Trial
Authors: Mikosinski Jacek , Di Landro Anna , Kasztalska-Kazmierczak Karolina , Soriano Emilie , Caverzasio Carol , Binelli Daniela , Falissard Bruno , Dereure Olivier
Published: January 2022

Introduction. Topical applications of hyaluronic acid (HA)–containing formulations, based on the complex and vital role of HA in all stages of the wound-healing process, are routinely used with standard therapy to promote faster healing of chronic wounds. However, evidence to guide clinical decisions on the use of topical HA in the healing of vascular leg ulcers is limited. Objective. This study compared the efficacy and safety of topical application of a hyaluronic acid cream vs a neutral comparator (identical cream without HA) in treating subjects with chronic leg ulcers of vascular origin. Materials and Methods. This was a prospective, multicenter double-blind randomized controlled trial. One hundred sixty-eight subjects with chronic leg ulcers of venous or mixed (venous and arterial) origin were randomized to receive either topical applications of 0.2% HA cream or neutral comparator cream for a maximum of 20 weeks. The primary efficacy endpoint was complete ulcer healing (100% reepithelialization of the wound area centrally assessed at 20 weeks or before and confirmed 3 weeks later). In both groups, topical treatment was associated with standard therapy (ulcer cleansing and optimized compression). Results. The proportion of subjects with centrally assessed complete healing of the target ulcer that was confirmed 3 weeks later (primary efficacy endpoint) was substantially higher in the HA cream group (31.3%) than in the neutral cream group (14.8%; P =.009). Results in the full analysis, per protocol, and as assessed by the investigator were consistent with primary results. No significant difference in treatment effect was observed when subjects were stratified according to baseline ulcer size (≤20 cm2 or >20 cm2) regardless of topical treatment. Safety and tolerability were comparable between treatments. Conclusions. Treatment of subjects with chronic leg ulcers of venous or mixed origin with HA cream is safe, well tolerated, and results in a higher rate of healing than a neutral comparator cream.
Wpływ pandemii na polską, bułgarską i czeską leksykologię w roku 2020 i na początku 2021
Authors: Satoła-Staśkowiak Joanna
Published: January 2022

Przedmiotem uwagi są szybko następujące podczas pandemii konsekwencje językowe – leksykalne (nowe słowa, zwielokrotniona częstotliwość użycia istniejących słów) i komunikacyjne, stanowiące dla językoznawców ciekawą podstawę do badań współczesnych języków, z których trzy: polski, bułgarski, czeski stały się fundamentem analizy i badań frekwencyjnych. Mimo że omawiane procesy językowe mają charakter globalny, to tendencje leksykalne w poszczególnych językach, jak i funkcje mowy realizowane są w różny sposób, z heterogenicznym natężeniem, dlatego warto przyjrzeć im się bliżej. Prezentowany w artykule materiał został wyekscerpowany z dostępnych w sieci i na bieżąco notujących jednostki języka źródeł. Były nimi korpusy językowe: Narodowy korpus języka polskiego, Bułgarski narodowy korpus, Czeski narodowy korpus, autorski Polsko-bułgarsko-rosyjski korpus równoległy, którego autorka artykułu jest współautorką, i przeglądarki typu: frazeo.pl czy slowanaczasie.pl oraz słowniki elektroniczne, na przykład miejski.pl. Pomocne stały się polskie, bułgarskie i czeskie programy publicystyczne i informacyjne, a także najmłodsza, choć nieliczna, literatura naukowa.
Коронавирус – невидимый противник. Военная лексика в языковом образе пандемии в медийных текстах
Authors: Jóźwiak Jolanta
Published: January 2022

Во время пандемии коронавируса в национальных языках появились языковые инновации, но многие уже существующие слова также использовались для описания новой „коронавирусной” реальности. Целью исследования является анализ использования когнитивной метафоры Коронавирус – это Война в российском медиадискурсе. На примере отбранных интернет-текстов выделена специфическая лексика, позволяющая описать борьбу с пандемией с помощью военной терминологии. Из проведенного анализа вытекают два основных вывода. В текстах есть базовые лексемы, которые позволяют активировать коллективные модели мышления о пандемии в категориях войны. Кроме того, в анализируемых текстах можно наблюдать сужение или расширение значения ключевых слов периода пандемии. Лексические маркеры, указывающие на исходный домен ВОЙНА, применяются независимо от размера территории – это может быть мир, страна, город, больница, жилье, где люди защищают себя и других от коронавируса. Можно сделать вывод, что военная метафора эффективна при описании чрезвычайных ситуаций, таких как пандемия коронавируса. Использование такого типа метафоры в текстах СМИ помогает справиться с угрозой, объяснить, что происходит, а также влиять на поведение людей, направляя их мышление в определенную область.
Gwara miejska jako determinant tożsamości regionalnej na przykładzie współczesnej gwary miejskiej Poznania
Authors: Szymańska-Galińska Karina
Published: January 2022

Artykuł przedstawia gwarę miejską w kontekście determinanta tożsamości regionalnej. Autorka analizuje definicje gwary i wskazuje na zmieniający się odbiór tego pojęcia, jak i jego charakter i obecną rolę. Omówiona jest także tożsamość regionalna i jej korelacja z gwarą. Niniejsze rozważania eksplikowane są na przykładzie współczesnej gwary miejskiej Poznania, która mimo coraz mniejszej liczby czynnych użytkowników wykazuje wzrost popularności i chęć kultywowania w formach pozwalających postrzegać ten język w aspektach tożsamości regionalnej. Gwara poznańska analizowana jest w kontekście historycznym, gdzie wskazano na istotny wpływ języka niemieckiego oraz przemian gospodarczo-społecznych miasta na kształtowanie się języka mieszkańców Poznania. Artykuł rozpatruje gwarę miejską także we współczesnym ujęciu, omawiając jej występowanie w radiu, tekstach i książkach.
Metafory konceptualne w niemieckich związkach frazeologicznych odnoszących się do ludzkich procesów poznawczych
Authors: Iwaniak Kamil
Published: January 2022

Artykuł porusza zagadnienie metafor konceptualnych jako podstawowego narzędzia ludzkiego poznania i konceptualizacji pojęć abstrakcyjnych. Opisuje sposób ich tworzenia oraz funkcjonowania w języku potocznym. Tekst zwraca uwagę na rolę związków frazeologicznych jako językowych sposobów realizacji metafor poznawczych. Analizie poddano wybrane związki frazeologiczne odnoszące się do sfery ludzkiego umysłu.
Historia języka ukraińskiego z perspektywy planowania językowego (UKR)
Authors: Beley Les
Published: January 2022

Historia języka ukraińskiego w artykule jest rozpatrywana z punktu widzenia planowania językowego – koncepcje H. Klossa, J. Fishmana oraz W. Crofta. Procesy ausbauzacji i einbauzacji, szczegóły regionalne całego kontinuum dialektalnego zostały opisane z uwzględnieniem wpływów języków: rosyjskiego, polskiego, węgierskiego i rumuńskiego.
PENALTIES FOR MINORS: COMPARATIVE LEGAL RESEARCH
Authors:   Dnipropetrovsk State University of Internal Affairs, Skok Oleksandra
Published: January 2022

The article defines the age characteristics of minors in accordance with the Family Code of Ukraine, the Criminal Code of the Republic of Kazakhstan, the Criminal Code of the Republic of Tajikistan and the Criminal Code of the Republic of Azerbaijan. The quantitative indicators of minors who, in 2020-2021, were notified of suspicion of committing criminal offenses, minor crimes, grave crimes and especially grave crimes, are given. The types of punishments provided by the criminal codes of Ukraine, Kazakhstan, Tajikistan and Azerbaijan, which can be imposed by the court on persons who have committed a criminal offense, at the age of fourteen to eighteen, have been determined. Taking into account the provisions of the Criminal Code of Ukraine, an analysis of punishments in the form of a fine, community service, correctional labor, arrest and imprisonment was carried out. The article analyzes the provisions of the Criminal Code of the Republic of Kazakhstan on punishments in the form of deprivation of the right to engage in certain activities, a fine, involvement in community service, correctional labor, restriction of freedom and imprisonment. The analysis of the content of the Criminal Code of the Republic of Tajikistan in terms of the features of punishments in the form of deprivation of the right to engage in certain activities, a fine, compulsory labor, correctional labor and imprisonment has been carried out. The analysis of punishments provided by the Criminal Code of the Republic of Azerbaijan in the form of a fine, community service, correctional labor, restriction of freedom and imprisonment has been carried out. The general and distinctive features characteristic of the list of punishments that can be assigned to minors have been established. The practice of the courts of Ukraine has been studied in relation to penalties in the form of a fine, correctional labor, community service and imprisonment. The works of domestic scientists are analyzed, on the basis of which, a circle of persons who have conducted research on individual issues on the responsibility of minors is determined.
Evaluation of nutrients removed and recycled in a commercial peach orchard over a 14-years-production cycle
Authors: Baldi Elena , Quartieri Maurizio , Sorrenti Givambattista , Toselli Moreno
Published: January 2022

Understanding nutrient dynamics within a peach orchard is fundamental to the development of accurate nutrient management practices. The present study investigated the nutrient uptake and redistribution in a 14-years-old commercial orchard in the Po valley. At the end of the experiment, trees were harvested, biomass and organ nutrient concentration were determined. Skeleton and roots accounted for the highest plant biomass, followed by fruits at harvest, pruned wood and abscised leaves; thinned fruits were less than 1 kg tree-1. The difference between the amounts of nutrients in leaves sampled in summer and in autumn (at abscission) was used to estimate the fraction of nutrients remobilized during the vegetative season inside the tree. The decrease of N, P, S, Cu, Mn and Zn concentration in abscised, compared to summer-sampled leaves was the result of the translocation of nutrients into fruits and storage organs. Nutrient circulation in a commercial nectarine orchard was calculated by determination of the fractions of each nutrient recycled (sum of nutrients in abscised leaves, thinned fruits and pruned wood) and remobilized (sum of nutrients in fruits at harvest, roots and skeleton). In our experimental conditions, on average, nectarine Stark RedGold showed an annual request of (in kg ha-1) 100, 17, 73, 129, 16, and 6 of N, P, K, Ca, Mg and S, respectively. More than half of these quantities were recycled in the orchard and returned back to the soil; consequently, if the nutrient use efficiency is maximized, the fertilization of nectarine requires only small amount of external inputs.
CONNECTIVE TISSUE HEART DYSPLASIA IN CHILDREN (LITERATURE REVIEW)
Authors: Mukhsinova Makhzuna Kholmuradovna
Published: January 2022

This article highlights the main domestic and foreign publications on the problem of connective tissue dysplasia of the heart in children. An interpretation of minor heart anomalies is given. Currently, the collection of additional high-quality data on the course and treatment of children is important to identify the most effective algorithms for patient management. Proper monitoring, early detection of complications of the disease, and the possibility of timely treatment are essential.
MODERN ASPECTS TO THE PROBLEM OF THE PREVALENCE OF HELICOBACTER PYLORI ASSOCIATED STOMACH DISEASES IN UZBEKISTAN
Authors: Ismailova Jadida Akhmedjanovna , A. Yusupbekov Akhrorbek
Published: January 2022

Introduction. We studied the regional epidemiological and genetic characteristics of the prevalence of Helicobacter pylori among the population of Uzbekistan. The work is based on the totality of the results of clinical, biochemical, immunological, genetic and instrumental research methods. Materials and Methods. It was established that Uzbekistan belongs to the regions with a high degree of H. pylori infection of the population (80%). 84% of the population of Uzbekistan have a mixed IceA1- / IceA2-genotype CagA. In peptic ulcer disease, the pathogenic strain CagA + VacA s1, VacA m2 and IceA 1,2 prevails, in chronic gastritis (type B) associated with H. pylori, the strain Cag + VacA s1, VacA m2 and IceA 1. Results and Discussion. The level of resistance of H. pylori strains to clarithromycin reaches 13.3%. Prolongation of eradication therapy up to 10 days and the addition of BTD to it makes it possible to increase the efficiency of H. pylori eradication up to 95%. Conclusion. Due to the presence of HP resistance to clarithromycin in 13.3% of cases and taking into account the low effectiveness of triadotherapy (72.5%), it is advisable to use quadritherapy with the inclusion of BTD in the standard of treatment, which contributes to an increase in the eradication efficiency up to 95%.
TUNNELED ADULT PERIPHERALLY INSERTED CENTRAL CATHETER (PICC) FOR CENTRAL VENOUS ACCESS IN PAEDIATRICS: A SINGLE CENTRE EXPERIENCE
Authors: Mortadza Nurul Nabila , Rajadurai Arvin , Ehsan Norhafizah , Arthimulam Ganesan , Nordin Noorshahrizal , Abdul Ghani Zulkifli Zaki
Published: January 2022

Objective: Long term intravenous access in paediatrics is challenging in terms of ease of procedure, maintenance of catheter and complications. Small calibre of peripheral veins in children make insertion of peripheral long-term access difficult. Our centre adopted the use of tunneled adult Peripherally Inserted Central Catheter (PICC) for central venous access in paediatrics with the hope to improve these challenges. We describe a single institute 3-year experience of this technique. Material & Methods: Retrospective analysis of patients aged less than 12 years old who had tunneled PICC insertions from January 2018 till December 2020. The following data was recorded and studied: indication, reason for removal, duration of PICC, vessel inserted, device type and complications. Results: Eleven adult PICCs were inserted from this technique in 10 children. The average age was 35.7months and weight was 13.2kg. The youngest patient was 3 months old at 6.9kg. Most common indication for insertion was for long term antibiotics (82%) and the remainder were for difficult intravenous access. The procedure was done under local anaesthetic with sedation in 90% of cases. Average duration of PICC was 26.8 days. Out of 11 PICCs only 1 had line related infection that required premature removal of the catheter. 55% completed the intended duration while 27% of PICCs had dislodged. Conclusion: Tunnelled adult PICC for central venous access in paediatrics is a feasible option for long term vascular access and has a lower risk of infection. However, almost a third of the catheters inserted still suffered premature dislodgement.
Comprehensive Guidance and Counseling Programs in Developing Student Talent
Authors: Lestari Lestari , Izzaty Rita Eka
Published: January 2022

This article provides an overview of multicultural competencies from a global perspective, specifically as it relates to counseling students in Indonesia. An overview will be given of the cultural interactions observed by counselor educators who were visiting professors at a university in Indonesia. While racial and ethnic diversity in countries such as Indonesia remain homogenous, cultural differences were noted with respect to the intersectionality of gender and disability.  The intersection of culture, gender, and disability present unique challenges for counselors trying to assist their clients. Thus, it is imperative that counseling students become culturally competent so they can assist their clients who come from varying backgrounds. Implications are given to counseling programs to increase their students’ multicultural competencies when working with global populations.
Multicultural Competence in Indonesian Counseling Students: Perspectives of Visiting American Counselor Educators
Authors: Robinson Mona , Savitsky Devyn
Published: January 2022

This article provides an overview of multicultural competencies from a global perspective, specifically as it relates to counseling students in Indonesia. An overview will be given of the cultural interactions observed by counselor educators who were visiting professors at a university in Indonesia. While racial and ethnic diversity in countries such as Indonesia remain homogenous, cultural differences were noted with respect to the intersectionality of gender and disability.  The intersection of culture, gender, and disability present unique challenges for counselors trying to assist their clients. Thus, it is imperative that counseling students become culturally competent so they can assist their clients who come from varying backgrounds. Implications are given to counseling programs to increase their students’ multicultural competencies when working with global populations.
The Management System of Medical Institutions of the Russian Empire of the Late 19th – Early 20th Centurу (on the Example of Eastern Siberia)
Authors:   Irkutsk State University, Shalamov V. A.
Published: January 2022

The medical sphere of Eastern Siberia was distinguished by a number of features. As for the entire Russian Empire, it was characterized by an extremely large number of departments and organizations that had their own medical organization. In Siberia, there was no zemstvo, which allowed archaic institutions to survive in the form of public charity decree and rural medical units, which were criticized for their inefficiency. City governments were reluctant to develop medical facilities, which encouraged private initiative. There were independent medical institutions for employees of the railway, water transport, mining departments, the cabinet of his Imperial Majesty, the army and the Trans-Baikal Cossacks. Siberia was the land of hard labor and exile, which provoked the emergence of medical institutions in prisons and in hard labor. The agrarian reform of P. A. Stolypin contributed to the resettlement of peasants to the east, including to Eastern Siberia. Medical services were created especially for them both on the way to Siberia and at the places of their new residence. In the cities, a number of public organizations (the Russian Red Cross Society, the Society of Doctors, the All-Russian League against Tuberculosis) created their own medical institutions.
The Policy of the Russian Authorities in Relation to Korean Migrants to the Russian Far East in the Second Half of the 19th Century
Authors:   Pacific National University, Ivanov A. Yu.
Published: January 2022

Resettlement of Koreans from northern Korea to Russian territory has been important in the development of the Russian Far East. In the first decade after the Amur region and Primorye was included in the Russian Far East, there was an acute shortage of labor. In this regard, before the Russian administration faced with the task to develop the Far Eastern suburbs and the establishment there of strong peasantry. The measures taken by the Russian authorities to provide protection and food aid to displaced persons in many ways contributed to the further relocation of Koreans in the Russian Far East.