bluuebunny/crossref_metadata_2025 huggingface dataset:
A profissão docente nas representações sociais de professores iniciantes de Ensino Médio
Authors: Machado Laêda Bezerra , Silva Mayara Corrêa da
Published: April 2020

Este artigo identifica as representações sociais do ser professor construídas por docentes de ensino médio em início de carreira. Adotamos como referencial a abordagem societal das representações sociais. O texto resulta de uma pesquisa qualitativa, que envolveu 15 professores de instituições públicas de Recife-PE. Utilizamos como instrumento de coleta de dados a entrevista semiestruturada. O material recolhido foi analisado com o auxilio do software Alceste. As representações do ser professor dos docentes de ensino médio ressaltam a importância do serviço prestado por esse profissional à sociedade. Os depoimentos, organizados em classes, sugerem representações sociais centradas na capacidade de mediação do conhecimento e possibilidade de transformação social. Contudo, tais representações estão marcadas pelo sentimento de desvalorização. Os iniciantes na docência reiteram que diferentes elementos de precarização afetam o ser professor hoje, tais como baixo prestígio social da profissão, má remuneração, exigências constantes por parte dos sistemas, indisciplina e desinteresse dos alunos. Além de detectar o cenário de desvalorização do docente de ensino médio e suas influências para as práticas dos professores iniciantes, sugerimos a implementação de políticas públicas, que acolham e ofereçam maior suporte ao professor de ensino médio em início de carreira que atua na escola pública. Palavras-chave:  Professor. Ensino médio. Representações sociais. Iniciante.
O bom professor enfermeiro: o olhar dos estudantes de cursos técnicos acerca da prática docente
Authors: Rampellotti Luís Fernando , Pasqualli Roberta
Published: April 2020

A importância da formação do Técnico em Enfermagem está diretamente relacionada à complexidade do seu ofício, especialmente no que diz respeito ao cuidado com a vida humana. Apesar disso, o Enfermeiro que leciona na educação profissional é formado, majoritariamente, em cursos de Bacharelado e não em Licenciaturas, que são os cursos destinados à formação inicial de professores. Nessa direção, o objetivo deste texto é apresentar, a partir do olhar dos estudantes dos cursos Técnicos em Enfermagem, do município de Joinville – SC o que se chamou de bom professor enfermeiro. Discutem-se categorias relacionadas aos saberes docentes e às práticas educativas desse professor. A metodologia utilizada foi de abordagem qualitativa, do tipo descritiva, com dimensão exploratória. Como resultados, destaca-se que os professores foram apontados como produtores de saberes a partir de seu ofício cotidiano e, nesse sentido, a experiência e o exercício da profissão, quer seja da docência ou da prática da Enfermagem empoderam a tomada de decisões didático-pedagógicas dos professores. Os estudantes apontam, como saberes fundamentais ao exercício da docência do bom professor enfermeiro, aspectos relacionados ao saber fazer, ao saber ser, ao saber agir e aos saberes específicos da docência. Para eles, o bom professor enfermeiro inspira, motiva, estimula e compartilha responsabilidades. Atitudes como dedicação e abertura de espaços para retirar dúvidas e recuperar dificuldades de aprendizado, abertura às demandas dos estudantes, ética e as relações que o professor estabelece entre os conteúdos e o exercício da profissão também foram apresentadas. Palavras-chave: Práticas Docentes. Enfermagem. Ensino.
A produção do conhecimento sobre facebook e educação no portal de periódicos da CAPES: relatos de experiências docentes
Authors: Santos Willian Lima , Ferrete Anne Alilma Silva Souza , Alves Manoel Messias Santos
Published: April 2020

Com os avanços decorrentes da web 2.0, as interfaces que permitem interação e compartilhamento de conteúdos ganham novas funcionalidades que vão além do entretenimento. Nessa perspectiva, o Facebook, como rede social de maior destaque no mundo, pode estar alinhado a uma proposta pedagógica e servir como recurso didático, independentemente da modalidade de ensino. Nesse contexto, este estudo tem como principal objetivo refletir sobre o uso da plataforma do Facebook como recurso didático-pedagógico com foco na aprendizagem colaborativa. Trata-se de um estudo de cunho bibliográfico de natureza qualitativa, caracterizado pela construção de um estado da arte, em que serviram como fonte de pesquisa os artigos científicos disponíveis no Portal de Periódicos da CAPES publicados entre janeiro de 2014 e dezembro de 2018. Por meio das análises das produções acadêmicas, foi possível verificar um maior engajamento por parte dos docentes em relação à inserção de novas metodologias de ensino voltadas para o uso das TDIC na educação, aprimorando a comunicação e a interação entre discentes e docentes e, consequentemente, o aperfeiçoamento de um cenário virtual de aprendizagem e compartilhamento de dados. Palavras-chave: Facebook. Educação. Recurso didático-pedagógico.
Sentidos atribuídos à formação técnica integrada ao Ensino Médio por estudantes
Authors: Amorim Junior Jorge Washington de , Urnau Lílian Caroline
Published: April 2020

Neste trabalho, o objetivo é analisar os sentidos que estudantes atribuem à sua formação em um curso técnico integrado ao ensino médio. À luz do referencial da Psicologia Histórico-Cultural e por meio de entrevistas semiestruturadas, realizamos uma pesquisa com quatro adolescentes, estudantes do último ano do Curso de Edificações no Instituto Federal de Educação, Ciência e Tecnologia de Rondônia (IFRO). Os resultados demonstram que a contradição atravessa a formação profissional ofertada e recebida pelos estudantes, uma vez que seu objetivo é prepará-los para o mercado de trabalho e, ao mesmo tempo, auxiliar na preparação e na continuidade da escolarização no ensino superior. Tal dualidade estrutural impacta significativamente na formação de sentidos para os alunos, os quais acreditam estar em vantagem no cenário competitivo do mercado de trabalho, ao mesmo tempo em que observam desvantagens no ingresso ao ensino superior. Em vez da ênfase no ensino propedêutico, em um curso técnico, o foco maior é nos conhecimentos técnicos específicos à formação em engenharia civil e arquitetura, por exemplo. Além disso, os sentidos predominantes revelaram a contraposição entre oportunidades educativas e perspectivas de futuro para esses jovens de camadas populares. O excesso de atividades de estudo e de cobranças é por eles considerado como meio para que atinjam mais autonomia e responsabilidade, entendidas como requisitos importantes na inserção competitiva. Palavras-chave: Adolescência. Educação Técnica integrada ao Ensino Médio. Sentidos.
HANDLING HIGHLY IMBALANCED OUTPUT CLASS LABEL
Authors: Khamsan Muhammad Muhaimin , Maskat Ruhaila
Published: April 2020

In practice, a balanced target class is rare. However, an imbalanced target class can be handled by resampling the original dataset, either by oversampling/upsampling or undersampling/downsampling. A popular upsampling technique is Synthetic Minority Over-sampling Technique (SMOTE). This technique increases the minority class by generating synthetic class labels and assigned the class based on the K-Nearest Neighbour (K-NN). SMOTE upsampling can only upsample at most one minority class at a time, which means for a multiclass dataset, it needs to undergo multilayer SMOTE to balance the class label distribution. This paper aims to find a suitable method in handling imbalanced class using dataset from Fantasy Premier League (FPL) virtual player to predict price changes. The cleaned dataset has a highly imbalanced class distribution, where the frequency of “Price Remain Unchanged (PRU)” is higher than “Price Fall (PF)” and “Price Rise (PR)”. This paper compared between the baseline (original) dataset, SMOTE-applied dataset and shuffled, linear and stratified sampling in split train-test subset, based on a deep learning algorithm. This paper also proposed criteria of low values in standard deviation (distribution of true positive on each class label on accuracy) as a measurement for finding the best method in handling imbalanced class labels. As a result, multilayer SMOTE until all the classes distribution is the same, combined with stratified sampling in split training and testing subset, get the lower standard deviation (5.7873), high accuracy (80.06%) and less execution runtime (1 minute 41 seconds) compared to the original highly imbalanced dataset.
WORLDS, OBJECTS, AND THEORIES OF FICTION
Authors: RUSU Mihai
Published: April 2020

The main aim of this paper is to provide a critical discussion of some key issues concerning the possible-world analysis of fiction. After a review of the most important philosophical questions concerning truth, reference, names and identity, and their bearing on fiction, I outline the possible-world framework, as used by David Lewis (1978) in his analysis, and examine its most important problems. A special interest is granted to the limits of the Lewisian pretense interpretation of fiction that are highlighted by works of cinema. I conclude with an appraisal of the puzzles generated by the attempts to draw borders between and within the worlds of fiction, and emphasize the need for a better mutual understanding of the two perspectives that are essential for a possible-world interpretation of fiction: literary theory and philosophy.
JELINEK ET HANEKE. LA FEMME ÉVISCÉRÉE COMME OBJET DU REGARD
Authors: CÂMPEAN Noemina
Published: April 2020

Jelinek and Haneke. The Eviscerated Woman as the Object of Gaze. This paper aims to explore a psychoanalytical comparison between Erika from the novel The Piano Teacher (Die Klavierspielerin, 1983), and the same character from the Michael Haneke’s film, La Pianiste (2001), adapted after Elfriede Jelinek’s writing. Whereas the woman in the book can only exist as a mask in order to exist as a phallus (the version of the father, Fr. la Père-version) – according to Jelinek’s obsession with the monstrous couple eye-gaze, expressed in an unnatural sexuality –, the woman on the screen is caught between the instances of embedding (the woman as uterus – the mother, the woman as a living tomb – the daughter) and the demystification of sexuality which culminates in rape.
L’INDIVIDU, UN SUJET DE DROIT OU UN ANIMAL SYMBOLIQUE ? MALAISE DANS LE DROIT
Authors: AMAR Jacques
Published: April 2020

The individual, a subject of law or a symbolic animal? Discomfort in the law. How can it be explained that the text concerning the prohibition of religious signs in the public sphere in France can be justified in the name of human rights in France and condemned in the name of human rights at the United Nations? The present article attempts to explain this situation on the basis of the notion of dispute expounded by J. F. Lyotard; it tries to explain the new trends in contemporary law on the basis of the distinction between dispute and litigation.
ON FLEXURAL PHONONS IN GRAPHENE. THERMAL CONDUCTIVITY AND SPECIFIC HEAT
Authors: GROSU I. , CRISAN M.
Published: April 2020

We analyzed the phonon spectrum of graphene. The flexural phonon contribution on thermal properties of graphene is discussed. The thermal conductivity has been calculated using the Boltzmann equation in the relaxation time approximation. The temperature dependence of the thermal conductivity and of the phonon specific heat has been calculated in the low temperatures domain.
INSTALLATION FOR SHORT TIME HEAT TREATMENT AT HIGH TEMPERATURE
Authors: HIRIAN R.
Published: April 2020

The design of a simple installation for short time annealing of nanomaterials at high temperature is presented. The installation is capable of heating rates of over 20 °C/s and cooling rates of up to 80 C/s with a maximum attainable temperature of 1050 °C.
LOW-COST, LOAD CELL AND MICROCONTROLLER BASED BENDING STIFFNESS TESTER
Authors: KAPUSI Z. , TUNYAGI A. , SIMON A.
Published: April 2020

Paper and paperboard have many applications, from writing, printing and householding to packaging. Bending stiffness is probably the most important mechanical property of paper and paperboard, it provides rigidity in some industrial processes like printing or folding. The present work describes the design and implementation of a low-cost bending stiffness tester proposed as a graduation project for Engineering Physics students. The performances of the device were successfully tested on both certified and real-life paper products.
“IN VIVO” ¹H NMR RELAXOMETRY MAPS OF WOMEN NORMAL AND CANCEROUS PELVIS
Authors: MORAR I. A. , PINTICAN R. , DAVID R. E. , KOVACS T. , FECHETE R.
Published: April 2020

Transverse relaxation time (T2) and 1H spin density ( ) parameter maps were obtained for the pelvis of two women. For that, two anatomical magnetic resonance (MR) images were recorded in axial orientation with a low echo time (TE1 @ 30 ms) and a large echo time (TE @ 200 ms) for a volunteer with normal pelvis and a patient with endometrial cancer. The largest –value was obtained for the right pelvic bones of patient with endometrial cancer and the lowest one was obtained for the uterus of volunteer with normal pelvis.
SCREENING OF POTENTIAL NEW SOLID FORMS OF VITAMIN B1 WITH VITAMIN B3
Authors: MURESAN-POP M. , PETRISOR D. M. , SIMON S.
Published: April 2020

The present study aimed to obtain new solid forms between Vitamin B1 (thiamine hydrochloride) and Vitamin B3 (nicotinamide) following the mechanochemistry route. The samples prepared by grinding in different solvents, of thiamine hydrochloride with nicotinamide in 1:1 and 1:2 molar ratios were investigated by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The XRD and FTIR results point out that for the chosen ratios of components and for the aqueous ethanol solution and for ethyl acetate used as solvents, none solid forms were obtained, but only physical mixtures. For the sample with1:2 molar ratio of B1:B3, the FTIR analysis reveals very small changes of few absorption bands consisting in a weak shift towards higher wavenumbers, due to grinding process.
SOME ASPECTS OF THERMODYNAMIC PROPERTIES OF ETHYLENIMINE AND ETHYLENE GLYCOL LINEAR POLYMERS
Authors: PAŞCA R. D. , BEU T. A.
Published: April 2020

The two biopolymers, namely polyethy-lenimine (PEI) and polyethylene glycol (PEG) in linear configurations, with a different range of polymerization, containing between 3 and 25 repeat units, have been studied by means of 3 functions of state: enthalpy, entropy and Gibbs free energy in standard conditions, using density functional (DFT) calculations. The preliminary data show that the stability of the two polymers decreases with the increasing of their degree of polymerization, namely with the increasing of their chain length.
FEEDBACK CONTROL OF DC MOTORS WITH LONG RANGE HC 12 TRANSCEIVER AND ARDUINO
Authors: TODICA M.
Published: April 2020

The work demonstrates the possibility to control DC motors at long distance with feedback. The system uses the radio transceivers HC 12, Arduino board and LCD keypad shield. Complete description of the hardware and software parts of the system is presented.
Zdolność do przywracania męskiej płodności żyta z cytoplazmą sterylizującą CMS-C przez rośliny wybranych populacji pochodzących z Iranu i z Argentyny
Authors: HANEK MONIKA , STOJAŁOWSKI STEFAN
Published: April 2020

Żyto jest gatunkiem wykazującym silny efekt heterozji. Odmiany mieszańcowe pozwalają wykorzystać ten efekt w stopniu znacznie większym niż odmiany populacyjne. W hodowli odmian mieszańcowych wykorzystywany jest powszechnie system cytoplazmatycznej męskiej sterylności (CMS). Celem pracy było porównanie przywracania płodności w dwóch systemach CMS żyta (CMS-C i CMS-P) przez osiem populacji pochodzących z Iranu i Argentyny. W trzyletnim doświadczeniu polowym oceniano płodność mieszańców F1. Formami matecznymi mieszańców były dwie męskosterylne wersje linii wsobnej 541 – z cytoplazmą sterylizującą C oraz P. Formami ojcowskimi – pięć populacji irańskich i trzy argentyńskie. Męską płodność oceniano wzrokowo za pomocą 9-stopniowej skali Geigera i Morgensterna. Płodność mieszańców była zróżnicowana i zależała od źródła CMS oraz od populacji zapylającej. Ogólnie można jednak stwierdzić, że populacje irańskie w porównaniu z argentyńskimi efektywniej przywracały męską płodność w systemie CMS-P, a mniej skutecznie w systemie CMS-C.
Opłacalność stosowania biostymulatorów w uprawie fasoli zwykłej (Phaseolus vulgaris L.) odmiany ‘Orzeł’
Authors: NOWOSAD NATALIA , KOCIRA ANNA , KORNAS RAFAŁ
Published: April 2020

Celem pracy była ocena opłacalności stosowania biostymulatorów w uprawie fasoli zwykłej (Phaseolus vulgaris L.) odmiany ‘Orzeł’. Badania polowe przeprowadzono w latach 2016–2018. Nasiona fasoli odmiany ‘Orzeł’ wysiewano w każdym roku badań, w pierwszej dekadzie maja. W okresie wegetacji zastosowano biostymulatory: Asahi SL (w stężeniu 0,1 i 0,2%), Kelpak SL (w stężeniu 0,7 i 1%) i Terra Sorb Complex (w stężeniu 0,3 i 0,5%), w formie jednokrotnego (BBCH 12–13) lub dwukrotnego oprysku (BBCH 12–13 i BBCH 61). Po zbiorze roślin określono plon nasion (t·ha–1) z każdego poletka i obiektu badawczego oraz dokonano oceny opłacalności stosowania biostymulatorów. Zwiększyły one istotnie plon nasion fasoli o 14% i pozytywnie wpłynęły na opłacalność ich stosowania, jednak uzyskany efekt zależał od stężenia preparatu i przebiegu pogody w latach badań. W 2016 i 2017 r. najbardziej ekonomicznie opłacalne okazało się jednokrotne stosowanie Asahi SL, niezależnie od zastosowanego stężenia. Natomiast w 2018 r. korzystniejsze było jednokrotne stosowanie 0,2% roztworu tego preparatu, jak też jednokrotna aplikacja preparatu Kelpak SL w stężeniu 0,7%. Podsumowując, najbardziej opłacalne w ocenianym 3-leciu było jednokrotne (BBCH 12–13) stosowanie Asahi SL w wyższym stężeniu (0,2%).
Prevalence of atrial arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis
Authors: Rujirachun Pongprueth , Wattanachayakul Phuuwadith , Charoenngam Nipith , Winijkul Arjbordin , Ungprasert Patompong
Published: April 2020

Background/objectives

Little is known about atrial involvement in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Recent studies have suggested that atrial arrhythmia, including atrial fibrillation, atrial flutter (AFL), and atrial tachycardia, was common among these patients although the reported prevalence varied considerably across the studies. The current systematic review and meta-analysis was conducted with the aim of comprehensively investigating the prevalence of overall atrial arrhythmia and each atrial arrhythmia subtype in the setting of ARVC by identifying all relevant studies and combining their results together.

Methods

A comprehensive literature review was conducted by searching for published articles indexed in MEDLINE and EMBASE databases from inception through to 22 September 2019 to identify cohort studies of patients with ARVC that described the prevalence of atrial arrhythmia among the participants. The pooled prevalence across studies was calculated using a random-effect, generic inverse variance method of DerSimonian and Laird with a double arcsine transformation.

Results

A total of 16 cohort studies with 1986 patients with ARVC were included in this meta-analysis. The pooled prevalence of overall atrial arrhythmia among patients with ARVC was 17.9% [95% confidence interval (CI), 13.0–24.0%; I
2 88%], the pooled prevalence of atrial fibrillation of 12.9% (95% CI, 9.6–17.0%; I
2 78%), the pooled prevalence of AFL of 5.9% (95% CI, 3.7–9.2%; I
2 70%), and the pooled prevalence of atrial tachycardia of 7.1% (95% CI, 3.7–13.0%; I
2 49%).

Conclusion

Atrial arrhythmia is common among patients with ARVC with the pooled prevalence of approximately 18%, which is substantially higher than the reported prevalence of atrial arrhythmia in the general population.
The Macroeconomic Determinants and the Impact of Sanctions on FDI in Iran
Authors: Ghahroudi Mehdi Rasouli , Chong Li Choy
Published: April 2020

We examine the impact of the macroeconomic determinants of foreign direct investment inflows. We also investigate the moderating role of sanctions in FDI inflows into Iran. The results reveal that macro determinants such as infrastructure, exchange rate, inflation rate, investment return, and governance have a long-run effect on FDI inflows in Iran. Our findings also show that GDP growth rate and trade openness have no significant effect on FDI. Our results indicate that sanctions do not have a significant moderating role in the relationship between macroeconomic factors and FDI. Surprisingly, international sanctions have a positive relationship with FDI inflows in Iran. Furthermore, sanctions have a positive impact on the inflation rate and exchange rate in Iran. Finally, our findings show that sanctions have had a significant impact on Iran’s economic growth in recent years due to increasing the severity level of sanctions.
Seed productivity and variability of Scots pine (Pinus sylvestris L.) clones of Finnish origin in seed orchard in the central part of Ukraine
Authors: Neyko Ihor , Kolchanova Olena , Monarkh Veronika , Poznyakova Svitlana
Published: April 2020

Global climate change has mainly impacted the forest ecosystems in Europe. Today, it is not fully understood how these changes will affect the reproductive process of trees on seed orchards. The main aim of the study is to evaluate the growth, condition and reproductive function of Scots pine clones of Finnish origin after moving them to the southern direction of natural distribution area. Variability and seed productivity of 25-year-old clones of Scots pine of Finnish origin in the clonal seed orchard under climatic conditions of the central part of Ukraine (Vinnitsa region) was investigated. Grafted seedlings of Scots pine of Finnish origin were moved southward at a distance of over 1,500 km. Climatic conditions of Vinnytsia region, where the clones were displaced, differed by an increase in the mean and maximum temperatures by 3.3–3.6ºC, as well as an increase in the mean temperatures during the cold period and a rise in the minimum by 2.1–2.3ºC. The climate in the seed orchard location was characterized by the most significant increase in the mean temperatures in April and May (5.3–5.8ºC), which greatly influenced the intensity of the formation of microstrobili and macrostrobili. The ratio of precipitation to the amount of temperatures decreased more than twice. Analysis of the grafted trees’ vitality of Finnish origin and seed progeny of the local population, estimation of their intensity (height, diameter), state (category of the state) and reproductive processes (intensity of formation of microstrobili and cones) was carried out on the clonal seed orchard. In conditions of climate change, most of the clones of Finnish origin were characterized by a higher intensity of flowering compared to the local population. Some clones of Finnish origin (E80 and E729) dominated the local population by the seed yield. According to a comprehensive analysis of vitality, the intensity of growth and reproductive capacity, the best clones of Finnish origin were E80, E1883 and E2254. Low adaptive ability was noted in the clones E2312, K634 and K801. According to the research results, it was found that changes in climatic conditions did not significantly affect the vitality, development and condition of the clones. There was observed intensification of the formation of microstrobili and cones. Seed viability and quality of Scots pine of Finnish origin obtained on seed orchards located in the southern conditions requires further research.
Does time of protective procedure and genotype of chamomile affect yield?
Authors: Kowalska Jolanta , Seidler-Łożykowska Katarzyna , Jakubowska Magdalena , Drożdżyński Dariusz
Published: April 2020

Objective: Chamomile plants (Chamomilla recutita L. Rausch) are often attacked by pests, which usually cause the decrease of raw material yield and its quality. The objects of field trial were two chamomile cultivars: Złoty Łan (4n) and Promyk (2n) cultivated under organic regime. The aim of this study was to evaluate of impact of the spinosad treatment and its time of application on two chamomile cultivars: cv. Promyk – 2n and cv. Złoty Łan – 4n exposed to insect pests.

Methods: The first treatment with spinosad as a preventative control (P) was performed in the early phase of plant development (seven leaves). Intervention (I) treatment was made in green bud phase. In both terms of observation insect pests were observed and collected. In each spraying application of 0.06 g of spinosad per 1 liter of water was used.

Results: Spinosad was able to limit the number of pest population and finally increased yielding of the treated cultivars as compared to the untreated plants. Time of spinosad application for cv. Złoty Łan plants was not statistically siginificant, although was more effective for the preventative treatment of cv. Promyk in the increasing of the plant biomass (283.8 g · m−2) and seed (32 g · m−2) yields than intervention.

Conclusion: Protection treatment with spinosad might be recommended in chamomile cultivation and it is more effective than intervention in diploid cultivar which begin blooming earlier than tetraploid. Essential oil content was not related with protection treatment for diploid cultivar, although intervention in tetraploid cultivar caused higher content of oil.
Detection of circulating tumour cells in the breast cancer using CytoTrack system
Authors: Bogacz Anna , Wolek Marlena , Górska Aleksandra , Leporowska Ewa , Procyk Danuta , Kolenda Piotr , Litwiniuk Maria , Uzar Izabela , Gryszczyńska Agnieszka , Łowicki Zdzisław , Czerny Bogusław
Published: April 2020

Introduction: Plants are a rich source of healing substances. Cancer is a leading cause of death worldwide while breast cancer is the most common cancer among women. Circulating tumour cells (CTCs) are potential founder cells for metastasis. Therefore, their assessment may be used for monitoring of treatment as well as detecting cancer metastatis. Hence, it is suggested that the number of CTCs may be a valuable tumour biomarker during therapy.

Objective: The purpose of this study was to detect CTCs in breast cancer and to validate the method of assessment of CTC count using CytoTrack CT11 technology.

Methods: MCF-7 cells were sorted by a FACSARIA flow cytometer from blood samples derived from patients who have not been diagnosed with cancer. Identification and quantitative assessment of MCF-7 cells in blood samples were determined by flow sorting. Then, blood samples containing MCF-7 cells or without MCF-7 were scanned with the use of an automated fluorescence scanning microscope.

Results: In in vitro model analysing the glass CytoDisc™ with stained MCF-7 cells, we noted the correlation between the amount of observed tumour cells and expected number of tumour cells. Moreover, coefficient of variation in case of the recovery rate of the assumed number of MCF-7 cells was 30%, 17%, 18% and 15%, respectively.

Conclusion: Our study suggest that CTCs could be predictive factor in patients with metastatic cancer especially in breast cancer.
Antiprotozoal investigation of three Combretum species (Combretaceae) growing in Nigeria
Authors: Ogbole Omonike O. , Akinleye Toluwanimi E. , Segun Peter A. , Fasinu Pius S.
Published: April 2020

Introduction:
Combretum species has been utilised for decades in African indigenous medical practices for the treatment of several parasitic infections.

Objectives: This study aims at investigating the antileishmanial, antiplasmodial and antitrypanosomal properties of Combretum racemosum, Combretum platypterum and Combretum zenkeri.

Methods: The leaf extracts of the plants were screened against two strains of Plasmodium falciparum using Plasmodium lactate dehydrogenase (pLDH) assay; promastigote and amastigote forms of Leishmania donovani; and Trypanosoma brucei brucei using Alamar Blue assay. Cytotoxicity screening were also carried out on African green monkey kidney cell line (Vero) and human monocytic leukemia (THP-1) cell lines.

Results:
C. racemosum was active against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of P. falciparum (IC50 of 25.6 and 26.7 µg/ml, respectively) and exerted significant antiprotozoal activities against T. brucei brucei (IC50 = 18.44 µg/ml). The extract of C. platypterum displayed a slightly lower antiplasmodial activity when compared to C. racemosum, while C. zenkeri was inactive against the parasites. In addition, the extracts failed to display significant inhibitory activity on the proliferation of L. donovani.

Conclusions: This study supports the ethnomedicinal use of C. racemosum. Further research needs to be carried out to identify the antiprotozoal compounds in C. racemosum, as this could be explored for possible antiprotozoal drug development.
Leadership Coaching across Cultures
Authors: Chmielecki Michał , Contreras-Loera Marcela
Published: April 2020

Objective: The discussion presented in this paper focuses on the practical coaching techniques premised on lasting principles of human learning; principles that are crucial to coaching relationships of all kinds. The principles involved tap into years of psychological research and practice (Kanfer & Goldstein, 1991; Mahoney, 1991) that focuses on issues that prompt changes in people, the important factors that fosters relationships and the ways of getting people to give up their regular actions for a new set.

Methodology: The article’s research is based on extensive literature analysis.

Findings: The research was not able to identify the specifics of what people value in different cultures; however, it captures the major active ingredients in learning endeavor, without taking culture into consideration.

Value Added: The article discusses 3 main types of challenges that leadership coaches find across the globe and offers guidelines to handle them

Recommendations: Future papers on that topic research should include both qualitative and quantitative research findings.
Teachers’ Conceptions of Assessment for Learning: What are the Implications for Children?
Authors: O’Shea Amanda
Published: April 2020

This paper describes a multi-case study which linked conceptions and practices of assessment for learning to developing learner autonomy within UK primary mathematics classrooms. The project explored the use of assessment for learning in mathematics lessons with Year 5 (9–10 years old) children and their teachers. Four cases were studied in depth to understand how conceptions and practices impacted upon autonomy and control for teachers and learners. A typology of assessment for learning in mathematics is proposed, along with what this might mean for both teachers and learners in terms of the balance between control and autonomy. One case in particular, that of teacher Alex, is highlighted as it exemplified the expert teacher through the conceptions and use of assessment for learning, which led to the children becoming expert learners of mathematics. The class ethos was one of value for personal autonomy. Responsibility and control of learning was a shared endeavour within a community of learners. Community in this respect was broadened to include the environment and resources within the classroom and so demonstrated learners working within an expert classroom. This article was developed from a paper first presented at the ICME 13 conference (O’Shea, 2016).
A Case Study Exploring the Impact of Valuing Practices and Emotional Labour on the Well-being of one Senior Leader
Authors: Barrow Joanne , O’Shea Amanda
Published: April 2020

This article examines the theoretical frameworks of valuing practices and emotional labour in relation to a managerial position within a Higher Education setting. Positive aspects of these frameworks are explored along with challenges that can be faced by those striving to implement these management strategies in their practice. The methods used provided both qualitative and quantitative data via key vocabulary and phrases related to valuing practice and emotional labour as identified through observation and semi-structured interview, and the frequency of key vocabulary being used. The study takes the form of a case study. There is one participant who is a Higher Education employee working in a senior managerial position, line managing a small number of staff. This individual was chosen in order to explore their use of valuing practices and emotional labour within his management approaches. Analysis of the data identified a higher range of vocabulary relating to valuing practices than emotional labour. Overall conclusions are that valuing practices support the well-being of both leaders and staff through the motivation that is inspired by knowledgeable praise. Yet the possible risks of valuing practices should also be considered, such as non-engagement of staff. Emotional labour risks the well-being of leaders more so due to a difference in organisation and individual believes and ethos.
Language does not modulate fake news credibility, but emotion does
Authors: Fernández-López María , Perea Manuel
Published: April 2020

The proliferation of fake news in internet requires understanding which factors modulate their credibility and take actions to limit their impact. A number of recent studies have shown an effect of the foreign language when making decisions: reading in a foreign language engages a more rational, analytic mode of thinking (Costa et al., 2014, Cognition). This analytic mode of processing may lead to a decrease in the credibility of fake news. Here we conducted two experiments to examine whether fake news stories presented to university students were more credible in the native language than in a foreign language. Bayesian analyses in both experiments offered support for the hypothesis that the credibility of fake news is not modulated by language. Critically, Experiment 2 also showed a strong direct relationship between credibility and negative emotionality regardless of language. This pattern suggests that the driving force behind the engagement in an automatic thinking mode when reading fake news is not language (native vs. foreign) but emotionality.
Inconsistencies between mental fatigue measures under compensatory control theories
Authors: Muñoz-de-Escalona Enrique , Cañas José J. , Noriega Paulo
Published: April 2020

Mental fatigue has traditionally been defined as a condition of reduced cognitive efficiency and performance, accompanied by a subjective feeling of fatigue. Even though we could expect to find associations between the three defining characteristic of mental fatigue (performance impairment, physiological deactivation and subjective fatigue), research has shown that the emergence of inconsistencies between measures is more frequent than one might expect: people proved capable of maintaining adequate performance levels even after having declared themselves fatigued. This could be explained under the compensatory control mechanism models, which state that humans are able to provide additional resources under demanding conditions, but only at the expense of psychophysiological cost and subjective fatigue. We tested this explanation by manipulating task complexity and time performing a simulated air-traffic control task. We collected psychophysiological, performance and subjective data. A decrease in pupil size was seen in the low-aircraft-density condition, while pupil size remained constant in the high-aircraft-density condition. Participants’ task performance was optimal in both conditions, though they showed an increase in subjective feelings of fatigue, especially in the high-complexity task condition. Thus, complexity seemed to trigger compensatory mechanisms, which reallocated extra resources that physiologically activated participants in order to deal with a higher complexity task, whereas subjective fatigue could be acting as a signal to the organism of impending resource depletion. Our findings support compensatory control theories and offer an explanation of inconsistencies between fatigue measures. Further research on compensatory mechanisms is needed to enable better management of fatigue effects to prevent work-related accidents.
Pautas normativas y formas de racionalidad en la movilidad social afrodescendiente en Tuluá, Colombia
Authors: Zuluaga-Díaz Juan Carlos , Jaramillo-Marín Jefferson
Published: April 2020

El objetivo del artículo es reflexionar sobre algunas pautas normativas y formas de racionalidad en procesos de movilidad social de afrodescendientes residentes en Tuluá, Colombia. A nivel metodológico, usamos resultados previos de un estudio exploratorio sobre representaciones de movilidad social y su relación con factores objetivos en migrantes afrodescendientes y su descendencia en esta ciudad. Este estudio previo se desarrolló en el año 2013 con un enfoque biográfico. Como parte de los resultados se encontró que los criterios normativos y culturales, constituidos como pautas de orientación de valor, en ocasiones son consecuentes y en otras contrastantes entre los grupos estudiados. La principal conclusión es que las pautas normativas tienen un papel importante, tanto orientador como prescriptivo, según se perciban o no como ideales que facilitan los procesos de movilidad y las formas legítimas de ascenso social para los afro migrantes y sus descendientes en Tuluá, Colombia.
El concepto de vulnerabilidad macroeconómica. Una revisión de la literatura
Authors: Portillo-Riascos Luis Hernando
Published: April 2020

El objetivo de este estudio es hacer una revisión del significado y los alcances que tiene el concepto de vulnerabilidad macroeconómica (VM), enfatizando en la situación a la cual se enfrentan las economías en desarrollo. Para este propósito, se realizó una revisión bibliográfica de las publicaciones más relevantes acerca de este tema. Como resultado de este estudio, se identificaron tres enfoques que abordan el estudio de la VM: a) el estructural; b) el que asocia la VM con la ocurrencia de episodios de crisis; y c) aquel que plantea que la VM está relacionada con la inestabilidad macroeconómica real. Más allá de los contrastes que se encontraron entre las diferentes posturas teóricas, se concluye que la VM es un fenómeno muy arraigado en las economías latinoamericanas, cuyas consecuencias se han agravado como resultado de la profundización de la integración comercial y financiera que se ha dado en las últimas décadas.
Current trends in the incidence of late forms of syphilis in Novosibirsk
Authors: Khryanin Aleksey A. , Sukharev Philipp A.
Published: April 2020

The main trends in the incidence of syphilis, including its late forms, are analysed in Novosibirsk in 20132017. It was found that during this period there was a trend to a decrease in the incidence of syphilis in Novosibirsk, but there was an increase in cases of detection of late forms of syphilis, in particular late latent syphilis and neurosyphilis, mainly in men at the age of 40 years and older. A unique clinical case demonstrating the complexity of differential diagnosis of neurosyphilis is also presented.
IgG/IgA-pemphigus — extremely rare blistering autoimmune diseases
Authors: Karamova Arfenya E. , Znamenskaya Lyudmila F. , Chikin Vadim V. , Mihina Viktoria A. , Nefedova Maria A.
Published: April 2020

Purpose. To present a clinical case of IgG/IgA pemphigus in a 32-year-old woman.

Material and methods. Clinical and laboratory examinations were performed to diagnose the disease: cytological examination of an impression smear from the bottom of the erosion, histological examination of a skin biopsy sample from the lesion, immunofluorescent examination of a biopsy sample of visually accessible unaffected skin.

Results. Clinical manifestations of the disease were similar to Duhring's dermatitis herpetiformis, morphological ones to pemphigus vulgaris, but immunofluorescent examination of the skin biopsy sample in equal measure revealed deposits of both IgG and IgA in the epidermis, which allowed to determine a diagnosis of IgG/IgA pemphigus. Dapsone therapy at a dose of 100 mg per day led to a significant improvement in the patient's condition.

Conclusion. Diagnosis of bullous dermatoses requires immunofluorescent examination of a biopsy sample of visually accessible unaffected skin. Dapsone was an effective medication for the patient with IgG/IgA pemphigus.
Prevalência de traço falciforme em doadores de sangue no hemocentro da cidade de Macapá
Authors: Pereira Yasmim Rabelo , Porcy Claude , Menezes Rubens Alex de Oliveira
Published: April 2020

Resumo: Este artigo buscou analisar a prevalência de portadores heterozigoto da hemoglobina S em doadores de sangue no Instituto de Hematologia e Hemoterapia do Estado do Amapá (HEMOAP). Foram analisadas as variáveis etnia e gênero nos períodos de 2016 e 2017, disponibilizadas pelo sistema de gerenciamento do banco de sangue Hemovida do Ministério da Saúde. Os resultados obtidos a partir das análises, nos anos de 2016 e 2017, foram, respectivamente, 1,75% e 1,3%; os dados revelaram que a prevalência entre esses doadores portadores é maior no gênero masculino da etnia mestiça. Adicionalmente, os portadores do traço falciforme são assintomáticos, sendo clinicamente e hematológicamente normais e aptos a doação de sangue. Conclui-se que a frequência do traço falciforme no HEMOAP salienta a importância de pôr em prática pesquisas sobre portadores falcêmicos em hemocentros, tendo como finalidade a melhoria da qualidade do sangue transfundido ao receptor e as orientações em saúde para o doador.
Conhecimento das mulheres sobre métodos contraceptivos em um município do sul do Tocantins
Authors: Da Silva Juliana Nascimento , Rodrigues Edinalva Carvalho Rocha , Alcântara Denise Soares de , Oliveira Laís Fernandes de , De Magalhães Claudia Christina Ribeiro Guimarães Neri , Pinheiro Julliana Dias , Silva Marília Pantoja Soares da , Ribeiro Mirelly da Silva , Barros Leandra Cristhyne de Souza , Abreu Nayara Pereira de
Published: April 2020

Objetivo: Analisar o conhecimento sobre métodos contraceptivos de mulheres cadastradas no Programa de Planejamento Familiar de três Unidades Básicas de Saúde em um município da região Sul do Tocantins. Métodos: Realizou-se um estudo descritivo, exploratório com abordagem qualitativa. A amostra consistiu em 16 mulheres, entre 18 a 40 anos de idade. Os dados foram coletados por meio de entrevista semiestruturada, entre os meses de setembro e novembro de 2019. Os resultados foram analisados pela técnica de análise de conteúdo. Resultados: A maior parte das entrevistadas era casada, possuía filhos, conhecia e já havia utilizado algum tipo de método contraceptivo, relatou maior segurança no uso da pílula e preservativo masculino. Conclusão: O estudo mostrou a necessidade constante de esclarecer a população feminina sobre métodos contraceptivos, assim como cada uma de suas particularidades, para que possam escolher e planejar o momento ideal para o nascimento de seus filhos.
Análise das metas de controle da tuberculose no Brasil: uma revisão narrativa
Authors: Da Silva Kelly de Oliveira Galvão , Nascimento Maikiane Aparecida , Carvalho Valéria Moura de , Oliveira Gabriela Cavalcante , Soares Ailton José , Furtado Andrea Cândida dos Santos , Borges Marielly Sousa , Dietz Jefferson do Carmo , Silva Nayara Messias da
Published: April 2020

Objetivo: Destacar as metas de controle da tuberculose e os indicadores epidemiológicos, que serão monitorados a cada triênio a partir de 2017, e traçar um paralelo entre as metas que já foram e as que devem ser alcançadas. Revisão Bibliográfica: O país, apesar de ser referência mundial no controle da tuberculose e ter alcançado antecipadamente as metas dos Objetivos de Desenvolvimento do Milênio antes de 2015, ainda não alcançou as metas do End TB, contudo vem demostrando redução nos indicadores. Assim, a meta da nova estratégia de enfrentamento da tuberculose é que, até 2035, o mundo esteja livre da doença. Para isso, medidas que versam sobre atenção ao paciente, componente social e pesquisa e inovação devem ser adotadas, sendo este tema prioritário, de acordo com o Plano Nacional de Promoção de Saúde na busca da erradicação do agravo. Considerações finais: Diante disso, é fundamental que haja o aprimoramento na educação permanente dos profissionais da área da saúde a fim de alcançar as metas propostas.
Incompetência istmocervical: cerclagem de emergência versus conduta expectante
Authors: Rego Sabrina Cabral , Martins Adelaide Gomes , Mesquita Francisca Amanda de Souza
Published: April 2020

Objetivo:Descrever sobre incompetência istmocervical:cerclagem de emergência versus conduta expectante.Revisão bibliográfica:Estudos anteriores indicaram que existe benefício quanto ao tratamento cirúrgico, uma vez que gestantes tem maior período de latência até o parto, maior idade gestacional ao nascimento e diminuição de taxa de prematuridade. Mulheres acometidas à cerclagem cervical para o tratamento da incompetência istmo cervical (IIC)continuama possuir risco elevado para prematuridade. Já na cerclagem de emergência têm-se maiores taxas de prematuridade e de maiores complicações se correlacionada a cerclagem profilática ou terapêutica.. E, de maneira geral, a cerclagem aumenta o risco de infecções puerperais (6%), internações hospitalares e de realização de cesarianas.Considerações finaisO diagnóstico de incompetência cervical embasa, primariamente, na história clínica, podendo ser efetuado antes ou durante a gestação. A cerclagem é a conduta com maior aceitabilidade de acordo com a literatura, devido aos índices de sobrevivência fetal e das gestantes portadoras de IIC no período que antecede o parto e após passar pelo  tratamento e procedimento cirúrgico.
Comparative Computational Study of SARS-CoV-2 Receptors Antagonists from Already Approved Drugs
Authors: Lima de Oliveira Micael Davi , Teixeira de Oliveira Kelson Mota
Published: April 2020

According to the World Health Organisation, on March 27, 2020, the number of confirmed cases of COVID-19 has already exceeded 509.000 with about of 23.000 deaths worldwide. Given this, the impact of COVID-19 on humanity cannot be overlooked, and basic research are urgently needed. This research aims to find antagonists already approved for another diseases, that may inhibit activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as modulate the ACE2 receptors, largely found in lung cells and reduce viral replication by inhibiting NSP12 RNA Polymerase. Docking molecular simulations were realized among a total of 28 ligands published in the literature against COVID-19. Docking studies were made with algorithm of AutoDock Vina 1.1.2 software. A structure-based virtual screening was performed with MTiOpenScreen. Subsequently, the physical-chemical and pharmacokinetic parameters were analyzed with SwissADME in order to select only the most promising ones. Finally, simulations of molecular dynamics with elapsed time of 4 nanoseconds (ns) were analysed in order to better understand the action of drugs to the detriment of the limitations of molecular docking. This work has shown that, in comparative terms, Simeprevir, Paritaprevir, Remdesivir and Baricitinib are currently among the most promising in remission of symptoms from the disease. Hydroxy-chloroquine, Chloroquine and Azithromicin were not showed effective, as monotherapies, against COVID-19 or lung cell receptors. Nevertheless, it has not been able to reach conclusive results due to the limitations of computational techniques that do not take into account numerous empirical parameters.
Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents
Authors: Liu Lei , Lee Wes , Youshaw Cassandra R. , Yuan Mingbin , Geherty Michael B. , Zavalij Peter Y. , Gutierrez Osvaldo
Published: April 2020

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.