bluuebunny/crossref_metadata_2025 huggingface dataset:
An experimental study on monitoring of marine sediment transport by using a 3D sediment trap
Authors: Guo Lei , Fei Zihang , Liu Tao , Xu Zhihao , Yang Xiuqing , Liu Xiaolei
Published: November 2023

The observation and analysis of sediment transport in oceans is an important means for the protection of the marine environment, resource development, construction engineering, and element cycling. However, traditional methods of observing sediment transport are either limited by the range of the instruments used or their own observational attributes, such that they cannot be used to accurately detect and analyze the process of transport of marine sediment. A 3D sediment trap has been proposed to compensate for the shortcomings of the various monitoring tools in our team, but no mature method for the analytical inversion of the data obtained from this device has been developed to date. In this paper, we developed analytical methods to invert sediment transport processes using corrected capture efficiency, sample inversion, and transport flux analysis. Through an annular flume test, we measured the turbidity, pressure, and particle size of the water stream and substituted them into the proposed analytical equations, thus verifying the applicability of the analytical methods. We used the slice experiment of the time series of the sediment samples, to determine the validity of the sample inversion, and establish the relationship between the particle size and concentration of the captured samples. We performed restoration tests on the process of sediment transport to establish a set of methods of flux analysis based on the velocity and turbidity of flow. And finally corrected for capture efficiency by particle size. The combination of analytical methods and 3D sediment trap could provide technological support for investigating the evolution of the sea, ecological cycle, and marine engineering.
Nano-liposome of thyme essential oil promotes growth performance, antioxidant and immune responses to aeromonad septicemia in Nile tilapia, Oreochromis niloticus, fingerlings
Authors: Yousefi Morteza , Hoseini Seyyed Morteza , Ghadamkheir Maryam , Mahboub Heba H. , Vatnikov Yury Anatolyevich , Kulikov Evgeny Vladimirovich , Sotnikova Elena Dmitriyevna
Published: November 2023

Nano-encapsulation protects essential oils and increases their efficiency, compared to bulk forms. Hence in the present study, four diets (328 g/kg crude protein and 4402 kcal/kg gross energy) containing 0 (CTL), 25 mg/kg (25TV), 50 mg/kg (50TV), and 100 mg/kg (100TV) thyme, Thymus vulgaris, essential oil nano-liposomes (TV-NP) were offered to Nile tilapia fingerlings (initial weight of 4.27 ± 0.05 g) at water temperature of 26.46 ± 0.43°C, followed by intraperitoneal infection by Aeromonas hydrophila. Three hundred and sixty healthy fish were stocked in 12 tanks (60 L), 30 fish per tank, with daily water renewal rate of 40%. Each diet was offered to three tanks for 70 days. The fish were sampled at the end of feeding period and 12 h after the bacterial challenge. Compared to CTL, 50TV and 100TV treatments exhibited significant elevations in growth rate (14-17%; P<0.001), intestinal activities of amylase (9-19%; P=0.004), lipase (13-26%; P<0.001), protease (20-23%; P=0.001), and post-challenge survival (26-27%; P=0.001). Plasma lysozyme (14-15% P<0.001) and complement (5.1-5.4%; P=0.004) activities significantly increased in 25TV and 50TV, but decreased (lysozyme: 19%, complement 5.9%) in 100TV before the challenge; however, all TV-NP treatments showed similar lysozyme and complement activities after the challenge that were higher than CTL. 50TV and 100TV treatments also showed a decrease in lipid peroxidation (23-26%; P<0.001) and highest glutathione peroxidase activity (17-18%; P=0.001) and pre-challenge superoxide dismutase (21%; P=0.046) and catalase (15-17%; P=0.001) activities. Expression of tumor necrosis factor-alpha (11-fold, P<0.001), inerleukin-1 beta (5-fold, P<0.001), and transforming growth factor-beta (31-fold; P=0.001) in head kidney significantly increased in 100TV before the challenge. After the challenge, the transcripts of the cytokines significantly increased in all treatments and the highest expressions were observed in 50TV and 100TV treatments (62-148-fold). In conclusion, dietary 50-100 mg/kg TV-NP can be considered as a new feed additive in tilapia culture, as it improves growth rate, antioxidant capacity, and disease resistance in the fish.
Global ocean spatial suitability for macroalgae offshore cultivation and sinking
Authors: Alevizos Evangelos , Barillé Laurent
Published: November 2023

Macroalgae offshore cultivation and sinking is considered a potentially practical approach for ocean-based carbon dioxide removal. However, several considerations need to be resolved to assess the effectiveness and sustainability of this approach. Currently, several studies focus on the area required for climate-relevant carbon sequestration through macroalgae cultivation and sinking without considering realistic, global spatial limitations. This study uses a spatially-explicit suitability assessment model for optimised open-ocean afforestation and sinking site designation. By applying specific maritime, ecological and industrial constraints, two maps are produced: a) suitable areas for macroalgae offshore cultivation and sinking, and b) suitable areas for macroalgae sinking only (for sequestration purposes). These data provide a more realistic approach to quantifying the ocean surface (including the corresponding depths) required for macroalgae offshore cultivation and sinking within a spatially sustainable framework. The resulting maps estimate the respective suitability areas within the EEZs of the world countries. A total area suitable for macroalgae offshore cultivation and sinking is calculated at 10.8M km2, whereas sinking-only areas account for 32.8M km2 of the offshore ocean. The implications of spatial suitability patterns at global and national levels are discussed. We suggest that the concept of ‘grow nearshore, sink offshore’ should be explored as an alternative to offshore cultivation.
Intestinal microbiota: a new perspective on delaying aging?
Authors: Zhang Yuemeng , Wang Xiaomei , Li Wujuan , Yang Yi , Wu Zhuoxuan , Lyu Yuhong , Yue Changwu
Published: November 2023

The global aging situation is severe, and the medical pressures associated with aging issues should not be underestimated. The need and feasibility of studying aging and intervening in aging have been confirmed. Aging is a complex natural physiological progression, which involves the irreversible deterioration of body cells, tissues, and organs with age, leading to enhanced risk of disease and ultimately death. The intestinal microbiota has a significant role in sustaining host dynamic balance, and the study of bidirectional communication networks such as the brain–gut axis provides important directions for human disease research. Moreover, the intestinal microbiota is intimately linked to aging. This review describes the intestinal microbiota changes in human aging and analyzes the causal controversy between gut microbiota changes and aging, which are believed to be mutually causal, mutually reinforcing, and inextricably linked. Finally, from an anti-aging perspective, this study summarizes how to achieve delayed aging by targeting the intestinal microbiota. Accordingly, the study aims to provide guidance for further research on the intestinal microbiota and aging.
Exploring the role of gut microbiota in advancing personalized medicine
Authors: Huang Gouxin , Khan Raees , Zheng Yilin , Lee Ping-Chin , Li Qingnan , Khan Imran
Published: November 2023

Ongoing extensive research in the field of gut microbiota (GM) has highlighted the crucial role of gut-dwelling microbes in human health. These microbes possess 100 times more genes than the human genome and offer significant biochemical advantages to the host in nutrient and drug absorption, metabolism, and excretion. It is increasingly clear that GM modulates the efficacy and toxicity of drugs, especially those taken orally. In addition, intra-individual variability of GM has been shown to contribute to drug response biases for certain therapeutics. For instance, the efficacy of cyclophosphamide depends on the presence of Enterococcus hirae and Barnesiella intestinihominis in the host intestine. Conversely, the presence of inappropriate or unwanted gut bacteria can inactivate a drug. For example, dehydroxylase of Enterococcus faecalis and Eggerthella lenta A2 can metabolize L-dopa before it converts into the active form (dopamine) and crosses the blood–brain barrier to treat Parkinson’s disease patients. Moreover, GM is emerging as a new player in personalized medicine, and various methods are being developed to treat diseases by remodeling patients’ GM composition, such as prebiotic and probiotic interventions, microbiota transplants, and the introduction of synthetic GM. This review aims to highlight how the host’s GM can improve drug efficacy and discuss how an unwanted bug can cause the inactivation of medicine.
Development of a reverse transcription loop-mediated isothermal amplification based clustered regularly interspaced short palindromic repeats Cas12a assay for duck Tembusu virus
Authors: Ding Yangbao , Huang Zhanhong , Li Xinbo , Tang Mei , Li Weiqiang , Feng Siyu , Zhao Luxiang , Zhang Junsheng , Yuan Shichao , Shan Fen , Jiao Peirong
Published: November 2023

Duck Tembusu virus (DTMUV) is an emerging pathogen that poses a serious threat to the duck industry in China. Currently, polymerase chain reaction (PCR), quantitative PCR (qPCR) and reverse transcription loop-mediated isothermal amplification (RT-LAMP) are commonly used for DTMUV detection. However, these methods require complex steps and special equipment and easily cause false-positive results. Therefore, we urgently need to establish a simple, sensitive and specific method for the clinical field detection of DTMUV. In this study, we developed an RT-LAMP-based CRISPR-Cas12a assay targeting the C gene to detect DTMUV with a limited detection of 3 copies/μL. This assay was specific for DTMUV without cross-reaction with other common avian viruses and only required some simple pieces of equipment, such as a thermostat water bath and blue/UV light transilluminator. Furthermore, this assay showed 100% positive predictive agreement (PPA) and negative predictive agreement (NPA) relative to SYBR Green qPCR for DTMUV detection in 32 cloacal swabs and 22 tissue samples, supporting its application for clinical field detection.
Dual RNA-Seq reveals transcriptionally active microbes (TAMs) dynamics in the serum of dengue patients associated with disease severity
Authors: Yadav Aanchal , Kumari Pallawi , Devi Priti , Adjele Jorelle Jeanne B. , Budhiraja Sandeep , Tarai Bansidhar , Pandey Rajesh
Published: November 2023

Introduction

Dengue virus (DENV) is a flavivirus that has emerged as a global health threat, characterized by either asymptomatic or mild self-limiting febrile illness, but a subset of DENV outbreaks have been associated with severe disease. Studies have looked into the host immune response and dengue viral load during infection. However, it remains unknown how the active microbial isolates modulate the dengue viral infection. In this study, we demonstrate the significance of in-depth analysis of microbiota composition in the serum samples of dengue-infected patients.

Materials and methods

RNA was extracted from the serum samples collected from 24 dengue positive patients. The human mapped reads generated through RNA-Sequencing (RNA-Seq) were removed, while the unmapped (non-human) reads were employed for microbial taxonomic classification using Kraken2 and Bracken2. Further, we assessed the initial blood parameters analyzing the complete blood count (CBC) profile of the patients.

Results

Findings revealed differential abundance of commensals and pathogenic microbes in the early febrile period of hospitalized dengue patients, segregated into, High Viral Reads (HVR) and Low Viral Reads (LVR). The Campylobacter genus was abundant in the HVR whereas Lactobacillus dominated the LVR patients. At species level, the microbiota of HVR exhibited higher abundance of unique potential opportunistic microbes, compared to the commensal microbes’ enrichment in the LVR patients’. We hypothesize that the DENV might alter the microbiota composition as observed by the increase in preponderance of opportunistic pathogens and an absence of commensals in the HVR. The presence of commensals in the LVR might explain, i) overall lower dengue viral reads compared to the HVR, and ii) shift in lymphocytes (high) and neutrophils (low) counts; resulting in a comparatively milder clinical manifestation in this group. Our findings may help in understanding the co-infection aspect that will be important to develop dengue therapeutics and vaccines.

Discussion

This study highlights the potential of the unexplored roles of the TAMs in modulating the dengue disease severity using the metatranscriptomic sequencing. This study serves to enhance our understanding of the distinctive microbial and hematologic signatures in the early infection stage that differentiate patients with high viral reads patients from those with low dengue viral reads.
Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
Authors: Feng Qi , Wang Luoyu , Tang Xue , Ge Xiuhong , Hu Hanjun , Liao Zhengluan , Ding Zhongxiang
Published: November 2023

Background

Neuroimaging studies have demonstrated alterations in hippocampal volume and hippocampal subfields among individuals with amnestic mild cognitive impairment (aMCI). However, research on using hippocampal subfield volume modeling to differentiate aMCI from normal controls (NCs) is limited, and the relationship between hippocampal volume and overall cognitive scores remains unclear.

Methods

We enrolled 50 subjects with aMCI and 44 NCs for this study. Initially, a univariate general linear model was employed to analyze differences in the volumes of hippocampal subfields. Subsequently, two sets of dimensionality reduction methods and four machine learning techniques were applied to distinguish aMCI from NCs based on hippocampal subfield volumes. Finally, we assessed the correlation between the relative volumes of hippocampal subfields and cognitive test variables (Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA)).

Results

Significant volume differences were observed in several hippocampal subfields, notably in the left hippocampus. Specifically, the volumes of the hippocampal tail, subiculum, CA1, presubiculum, molecular layer, GC-ML-DG, CA3, CA4, and fimbria differed significantly between the two groups. The highest area under the curve (AUC) values for left and right hippocampal machine learning classifiers were 0.678 and 0.701, respectively. Moreover, the volumes of the left subiculum, left molecular layer, right subiculum, right CA1, right molecular layer, right GC-ML-DG, and right CA4 exhibited the strongest and most consistent correlations with MoCA scores.

Conclusion

Hippocampal subfield volume may serve as a predictive marker for aMCI. These findings underscore the sensitivity of hippocampal subfield volume to overall cognitive performance.
Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol
Authors: Zhu Youzhuang , Feng Wei , Kong Qinghan , Sheng Fang , Li Zhichao , Xu Weilong , Li Qun , Han Yan , Wu Xiuyun , Jia Changxin , Guo Jie , Zhao Yang
Published: November 2023

Introduction

Postoperative delirium (POD) is an acute, transient brain disorder associated with decreased postoperative quality of life, dementia, neurocognitive changes, and mortality. A small number of trials have explored the role of S-ketamine in the treatment of POD due to its neuroprotective effects. Surprisingly, these trials have failed to yield supportive results. However, heterogeneity in delirium assessment methodologies, sample sizes, and outcome settings as well as deficiencies in S-ketamine use methods make the evidence provided by these studies less persuasive. Given the severe impact of POD on the health of elderly patients and the potential for S-ketamine to prevent it, we believe that designing a large sample size, and rigorous randomized controlled trial for further evaluation is necessary.

Methods

This is a single-center, randomized, double-blind, placebo-controlled, pragmatic study. Subjects undergoing total hip or knee arthroplasty will be randomized in a 1:1 ratio to intervention (n = 186) and placebo (n = 186) groups. This trial aims to explore the potential role of S-ketamine in the prevention of POD. Its primary outcome is the incidence of POD within 3 postoperative days. Secondary outcomes include the number of POD episodes, the onset and duration of POD, the severity and subtype of POD, pain scores and opioid consumption, sleep quality, clinical outcomes, and safety outcomes.

Discussion

To our knowledge, this is the first pragmatic study that proposes to use S-ketamine to prevent POD. We reviewed a large body of literature to identify potential preoperative confounding variables that may bias associations between the intervention and primary outcome. We will use advanced statistical methods to correct potential confounding variables, improving the test’s power and external validity of test results. Of note, the patient population included in this trial will undergo intraspinal anesthesia. Although large, multicenter, randomized controlled studies have found no considerable difference in the effects of regional and general anesthesia on POD, patients receiving intraspinal anesthesia have less exposure to at-risk drugs, such as sevoflurane, propofol, and benzodiazepines, than patients receiving general anesthesia. At-risk drugs have been shown to negatively interfere with the neuroprotective effects of S-ketamine, which may be the reason for the failure of a large number of previous studies. There is currently a lack of randomized controlled studies evaluating S-ketamine for POD prevention, and our trial helps to fill a gap in this area.

Trial registration: http://www.chictr.org.cn, identifier ChiCTR2300075796.
Immunology of amyotrophic lateral sclerosis – role of the innate and adaptive immunity
Authors: Mimic Stefan , Aru Başak , Pehlivanoğlu Cemil , Sleiman Hadi , Andjus Pavle R. , Yanıkkaya Demirel Gülderen
Published: November 2023

This review aims to summarize the latest evidence about the role of innate and adaptive immunity in Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease affecting upper and lower motor neurons, which involves essential cells of the immune system that play a basic role in innate or adaptive immunity, that can be neurotoxic or neuroprotective for neurons. However, distinguishing between the sole neurotoxic or neuroprotective function of certain cells such as astrocytes can be challenging due to intricate nature of these cells, the complexity of the microenvironment and the contextual factors. In this review, in regard to innate immunity we focus on the involvement of monocytes/macrophages, microglia, the complement, NK cells, neutrophils, mast cells, and astrocytes, while regarding adaptive immunity, in addition to humoral immunity the most important features and roles of T and B cells are highlighted, specifically different subsets of CD4+as well as CD8+T cells. The role of autoantibodies and cytokines is also discussed in distinct sections of this review.
Application of natural compounds in the treatment and prevention of prediabetes
Authors: Chen Jie , Jin Li , Chen Mengyao , Xu Kai , Huang Qi , He Beihui
Published: November 2023

Prediabetes is an intermediate stage in the development of type 2 diabetes mellitus characterized by impaired fasting glucose and/or impaired glucose tolerance. Prediabetes generally has no obvious clinical symptoms, and most patients are found in health examinations or due to other diseases. Reactive hypoglycemia may indicate the possibility of early diabetes. Without effective preventive measures, prediabetes can progress to diabetes leading to serious public health problems. Therefore, early diagnosis and intervention are important. Many animal experiments and clinical trials have proven that natural compounds substantially improve glucose metabolism disorder. The active ingredients are mainly alkaloids, polysaccharides, saponins, terpenoids, flavonoids and polyphenols. Their mechanism of action mainly involves improved insulin sensitivity and insulin resistance, inhibited activity of alpha-glucosidase, antioxidant activity, anti-inflammatory, regulation of gut microbiota and activating of peroxisome proliferator-activated receptor-γ. This paper reviews the mechanisms of action of natural compounds on prediabetes and the status of related research.
Quantifying technical load and physical activity in professional soccer players during pre-season matches with IMU technology
Authors: Losada-Benitez José Augusto , Nuñez-Sánchez Francisco Javier , Barbero-Álvarez José Carlos
Published: November 2023

This study aimed to record, analyze and quantify professional soccer players’ technical (TL) and physical load (PL) in friendly matches to compare their records during the first and second halves and between players with different positions. Eighteen professional soccer players, 24.6 ± 2.7 years, 1.78 ± 0.3 height (m), 74.6 ± 4.5 body mass (kg), 9.8 ± 2.2 body fat (%), and 65.6 ± 2.7 maximal oxygen consumption (VO2max, ml·kg-1·min-1) were monitored during six preseason friendly matches to analyze the activity profile using technical and physical variables through inertial measurement unit (IMU). No significant differences were found between the periods for the TL and PL. Significant differences were found between specific positions: Full Back (FB: n = 4), Central Defender (CD: n = 3), Midfielder (MD: n = 4), Winger (WG: n = 4), and Forward (FW: n = 3), both the TL and PL. We conclude that the PL profile based on his playing position is independent of the development of the PL shown during friendly matches. The monitoring, quantifying, and controlling of the TL added to the PL provides a more holistic vision of soccer players in friendly matches. The relative ease IMU application technology offers an alternative with less time-cost and more significant benefits than other types of technologies applied up to now.
Identification and functional characterization of the sugarcane (Saccharum spp.) AMT2-type ammonium transporter ScAMT3;3 revealed a presumed role in shoot ammonium remobilization
Authors: Maniero Rodolfo A. , Koltun Alessandra , Vitti Marielle , Factor Bruna G. , de Setta Nathalia , Câmara Amanda S. , Lima Joni E. , Figueira Antonio
Published: November 2023

Sugarcane (Saccharum spp.) is an important crop for sugar and bioethanol production worldwide. To maintain and increase sugarcane yields in marginal areas, the use of nitrogen (N) fertilizers is essential, but N overuse may result in the leaching of reactive N to the natural environment. Despite the importance of N in sugarcane production, little is known about the molecular mechanisms involved in N homeostasis in this crop, particularly regarding ammonium (NH4+), the sugarcane’s preferred source of N. Here, using a sugarcane bacterial artificial chromosome (BAC) library and a series of in silico analyses, we identified an AMMONIUM TRANSPORTER (AMT) from the AMT2 subfamily, sugarcane AMMONIUM TRANSPORTER 3;3 (ScAMT3;3), which is constitutively and highly expressed in young and mature leaves. To characterize its biochemical function, we ectopically expressed ScAMT3;3 in heterologous systems (Saccharomyces cerevisiae and Arabidopsis thaliana). The complementation of triple mep mutant yeast demonstrated that ScAMT3;3 is functional for NH3/H+ cotransport at high availability of NH4+ and under physiological pH conditions. The ectopic expression of ScAMT3;3 in the Arabidopsis quadruple AMT knockout mutant restored the transport capacity of 15N–NH4+ in roots and plant growth under specific N availability conditions, confirming the role of ScAMT3;3 in NH4+ transport in planta. Our results indicate that ScAMT3;3 belongs to the low-affinity transport system (Km 270.9 µM; Vmax 209.3 µmol g−1 root DW h−1). We were able to infer that ScAMT3;3 plays a presumed role in NH4+ source–sink remobilization in the shoots via phloem loading. These findings help to shed light on the functionality of a novel AMT2-type protein and provide bases for future research focusing on the improvement of sugarcane yield and N use efficiency.
“Finding happiness in daily work”: an ecological study on the emotions of novice EFL teachers in rural primary schools in China
Authors: Yao Yujing , Xu Jie , Yan Conggen
Published: November 2023

While research on teacher emotions has grown in the past decades, little is known about rural teachers’ and novice teachers’ emotions. Based on ecological theory, this study selected two novice EFL teachers as the research objects. The goal was to explore their emotional experiences and the factors that influenced them over 3 years while teaching in rural primary schools. The research data was collected primarily through semi-structured interviews, teaching diaries, and narrative frameworks. Three-step coding and topic analysis were used to analyze the collected data. The data analysis revealed that the two novice teachers generated 62 emotions while interacting with various ecosystems. In Microsystems, teacher-student interaction has a strong influence on participants’ emotions. Two participants experienced 19 positive emotions and 9 negative emotions during their interactions with the students. In addition, novice teachers may experience negative emotions if they are burdened with too many non-teaching tasks. In this study, two participants were able to effectively manage their negative emotions. The general emotional trend was positive, which motivated them to stay and continue teaching in the rural area. The results of this study have implications for the professional development of rural teachers and novice teachers.
Are acoustics enough? Semantic effects on auditory salience in natural scenes
Authors: Kothinti Sandeep Reddy , Elhilali Mounya
Published: November 2023

Auditory salience is a fundamental property of a sound that allows it to grab a listener's attention regardless of their attentional state or behavioral goals. While previous research has shed light on acoustic factors influencing auditory salience, the semantic dimensions of this phenomenon have remained relatively unexplored owing both to the complexity of measuring salience in audition as well as limited focus on complex natural scenes. In this study, we examine the relationship between acoustic, contextual, and semantic attributes and their impact on the auditory salience of natural audio scenes using a dichotic listening paradigm. The experiments present acoustic scenes in forward and backward directions; the latter allows to diminish semantic effects, providing a counterpoint to the effects observed in forward scenes. The behavioral data collected from a crowd-sourced platform reveal a striking convergence in temporal salience maps for certain sound events, while marked disparities emerge in others. Our main hypothesis posits that differences in the perceptual salience of events are predominantly driven by semantic and contextual cues, particularly evident in those cases displaying substantial disparities between forward and backward presentations. Conversely, events exhibiting a high degree of alignment can largely be attributed to low-level acoustic attributes. To evaluate this hypothesis, we employ analytical techniques that combine rich low-level mappings from acoustic profiles with high-level embeddings extracted from a deep neural network. This integrated approach captures both acoustic and semantic attributes of acoustic scenes along with their temporal trajectories. The results demonstrate that perceptual salience is a careful interplay between low-level and high-level attributes that shapes which moments stand out in a natural soundscape. Furthermore, our findings underscore the important role of longer-term context as a critical component of auditory salience, enabling us to discern and adapt to temporal regularities within an acoustic scene. The experimental and model-based validation of semantic factors of salience paves the way for a complete understanding of auditory salience. Ultimately, the empirical and computational analyses have implications for developing large-scale models for auditory salience and audio analytics.
Learning motivation and environmental support: how first-generation college students achieve success?
Authors: Li Xiaojing , Liu Weitong , Hu Ke
Published: November 2023

Introduction

With the continuous expansion of higher education worldwide, the academic performance of first-generation college students has become an essential topic in the scope of international educational research. This study examines the impact of learning motivation (i.e., intrinsic and extrinsic motivation) and environmental support (i.e., instructional, relational, and campus support) on the academic outcomes of first-generation college students based on the Cultural Mismatch Theory and Self-Determination Theory from both individual and environmental perspectives.

Methods

A two-stage stratified sampling strategy was adopted to guarantee that the samples were representative of the national populations of college students in mainland China. 87418 data were collected from the China College Student Survey (CCSS) 2020, among which 58,864 were first-generation college students. This study primarily employed descriptive statistical analysis and regression analysis methods.

Results

Data analysis revealed that intrinsic learning motivation, relational support, campus support, and academic performance of first-generation college students are significantly lower than those of non-first-generation students. However, this study found no significant differences concerning external learning motivation and teaching support. Regression analysis showed that both learning motivation and environmental support positively predicted learning outcomes, with intrinsic learning motivation having the most substantial influence. Moreover, learning motivation and environmental support interact in jointly promoting the student’s academic success.

Discussion

This study highlighted that the academic development of first-generation college students results from the interplay between individual characteristics and the surrounding environment. Postnatal factors, particularly individual learning motivation, and institutional environment support, play a crucial role in their academic achievements.
Art therapy in Alzheimer’s disease. An opportunity of collaboration between intersectoral public and private organizations in the co-design of health and social care services
Authors: Giusti Martina , Persiani Niccolò
Published: November 2023

Introduction

The World Health Organization (WHO) has recognized art therapy as an effective supportive mechanism for the maintenance and restoration of mental health. In recent years, art therapy has been integrated in the assistance pathways of older people affected by neurocognitive disorders according to the demonstrated benefits, as no conflicts with pharmacologic treatments and the reduction of anxiety and stress. The shortage of organizational, economic, and professional resources in social-health public organizations does not allow for guaranteeing the provision of these services without the help of the private ones, not exclusively belonging to social-health sector. This research aims to investigate how the collaboration between public and private organizations of different sectors in the co-provision of non-pharmacological approaches guarantees the economic sustainability and the quality improvement of the provided services.

Methods

The Alzheimer Café of Prato was selected as a significant case study.

Results and Discussion

Art therapy programs intended for taking care of older people in the first stages of the Alzheimer’s disease have been developed, planned, supplied, and managed over the years as a result of the integration of resources, ideas, and professionals provided both by public and private sectors, the social-health sector, and cultural organizations.

Conclusions

The peer-to-peer co-responsibility of all organizations (public and private, from the cultural sector as well as the social and health sector) involved in the co-design of art therapy programs, not limiting their actions to only co-financing and/or co-delivery of the service, enabled the achievement of the economic sustainability of the services and the improvement of their quality.
I don’t understand how I feel: mediating role of impaired self-mentalizing in the relationship between childhood adversity and psychosis spectrum experiences
Authors: Nonweiler Jacqueline , Torrecilla Pilar , Kwapil Thomas R. , Ballespí Sergi , Barrantes-Vidal Neus
Published: November 2023

Introduction

Childhood adversity is associated with the severity of multiple dimensions of psychosis, but the mechanisms underpinning the close link between the two constructs is unclear. Mentalization may underlie this relationship, as impaired mentalizing is found in various stages of the psychosis continuum. Nonetheless, the differential roles of self- and other-mentalizing in psychosis are not well understood.

Methods

Parallel multiple mediation was conducted for the relationship between a diverse range of childhood adversity types, including intentional and nonintentional harm, and schizotypy (positive, negative, disorganized), psychotic-like experiences (PLE) and paranoia via self-mentalizing (attention to emotions and emotional clarity) and other-mentalizing in n = 1,156 nonclinically ascertained young adults.

Results

Significant parallel multiple mediation models were found for all psychotic outcomes except negative schizotypy. The associations between intentionally harmful childhood adversity and psychotic outcomes were significantly mediated by increased attention to emotions for most models and decreased emotional clarity for some models. No significant mediation was found for parental loss. Paternal abuse was only mediated by attention to emotions whereas the effects of maternal abuse were mediated by attention to emotions and emotional clarity. Other-mentalizing only showed mediating effects on one of thirty models tested.

Conclusion

Results highlight the mediating role of impaired self-mentalizing in the association between childhood adversity and psychosis. This is consistent with disturbances of self-concept and self-boundary characterizing, in particular, the positive dimension of psychosis. Maternal versus paternal figures may contribute differentially to the development of mentalizing. These results could inform future preventative interventions, focusing on the development and maintenance of self-mentalizing.
Could reasons for admission help to screen unhealthy alcohol use in emergency departments? A multicenter French study
Authors: Chabert Jonathan , Lambert Céline , Cabé Julien , Cherpitel Cheryl J. , Rolland Benjamin , Moustafa Farès , Lesage Patrick , Ragonnet Delphine , Geneste Julie , Poulet Emmanuel , Dematteis Maurice , Naassila Mickael , Chalmeton Maryline , Llorca Pierre-Michel , Pereira Bruno , De Chazeron Ingrid , Brousse Georges
Published: November 2023

Background

Many patients admitted to general emergency departments (EDs) have a pattern of drinking that could lead to future alcohol-related complications. However, it is often difficult to screen these patients in the context of emergency. The aim of this study is to analyze whether reasons for admission could help to screen patients who have an unhealthy alcohol use.

Method

Patients were recruited among six public hospital ED in France, between 2012 and 2014. During a one-month period in each hospital, anonymous questionnaires including sociodemographic questions, AUDIT-C and RAPS4-QF were administered to each patients visiting the ED. The reason for admission of each patient was noted at the end of their questionnaire by the ED practitioner.

Results

Ten thousand Four hundred twenty-one patients were included in the analysis. Patients who came to the ED for injuries and mental disorders were more likely to report unhealthy alcohol use than non-harmful use or no use. Among male patients under 65 years old admitted to the ED for a mental disorder, 24.2% drank more than four drinks (40 g ethanol) in typical day at least four time a week in the last 12 months. Among these patients, 79.7% reported daily or almost daily heavy episodic drinking (HED, 60 g ethanol), and all were positive on the RAPS4-QF.

Conclusion

This study highlights that unhealthy alcohol use is frequent among ED patients and particularly among those who come for injuries or mental disorders. Men under 65 years old with a mental disorder require special attention because of their increased prevalence of daily or almost daily HED.
The causal configurations of provincial health policy innovation in China: an analysis of the food safety standard filing policy
Authors: Li Li , Han Guanghua , Chen Yanting , Zhang Zilin , Fu Xiao
Published: November 2023

Introduction

According to China’s Food Safety Law of 2015, the filing of food safety enterprise standards is a policy innovation led by p9rovincial governments in China. However, there are significant differences in the development of the “Food Safety Enterprise Standard Filing Policy” between provincial governments across the country. This study aims to explore the internal mechanisms driving autonomous innovation by provincial governments in the absence of administrative pressure from the central government, to better understand the policy innovation mechanism in the Chinese context.

Methods

Crispy Set Qualitative Comparative Analysis (csQCA) method is used to identify the innovation mechanism.

Results

This study found that provinces with good provincial economic resources and strong government capabilities are prone to policy innovation, and the influence of internal factors of provincial governments is stronger than that of external factors.

Discussion

When provincial economic resources and capacity are weak, endogenous factors in the province also help achieve proactive policy innovation by provincial governments. The research results reveal how provincial governments construct local policies in the absence of administrative pressure from the central government.
Work-family trajectories across Europe: differences between social groups and welfare regimes
Authors: Firat Mustafa , Visser Mark , Kraaykamp Gerbert
Published: November 2023

Introduction

Work and family trajectories develop and interact over the life course in complex ways. Previous studies drew a fragmented picture of these trajectories and had limited scope. We provide the most comprehensive study of early-to-midlife work-family trajectories to date.

Methods

Using retrospective data from waves 3 and 7 of the Survey of Health, Aging and Retirement in Europe (SHARE), we reconstructed work-family trajectories from age 15 to 49 among almost 80,000 individuals born between 1908 and 1967 across 28 countries. We applied multichannel sequence and cluster analysis to identify typical trajectories and multinomial logistic regression models to uncover their social composition.

Results

The results revealed six common trajectories. The dominant and therefore standard trajectory represents continuous full-time employment with having a partner and children. Women, the lower educated and persons from conservative and liberal welfare regimes are underrepresented in this trajectory, whereas men, higher educated people and those from social-democratic, Eastern European and Baltic welfare regimes are overrepresented. The other trajectories denote a deviation from the standard one, integrating a non-standard form of work with standard family formation or vice versa. Mothers in a stable relationship generally work part-time or not at all. When mostly in full-time employment, women are more likely to be divorced. Lower educated persons are less likely to have work-family trajectories characterized by full-time work and a non-standard family, yet more likely to be non-employed for large parts of their life with standard family formation. Younger cohorts are underrepresented in non-employment trajectories, but overrepresented in part-time employment trajectories along with a partner and children as well as full-time employment trajectories with divorce. Individuals from Southern European and liberal regimes are more likely to be non-working and self-employed partnered parents and those from social-democratic regimes are more likely to be full-time employed divorced parents. We also found pronounced gender differences in how educational level, birth cohort and welfare regime are associated with work-family trajectories from early to midlife.

Discussion

Our findings highlight the socially stratified nature of earlier-life work-family trajectories in Europe. Potential implications for inequalities in later life are discussed.
Hong Kong veterinarians’ encounters with client-related stress – a qualitative study
Authors: Chan Camille K. Y. , Wong Paul W. C.
Published: November 2023

Aims

Limited research has explored the stressors experienced by veterinarians in East Asia. Metropolitan cities like Hong Kong may have overlooked factors that significantly contribute to veterinarians’ stress. This paper examines how client-related stressors and contextual factors contribute to the stress levels of Hong Kong-based veterinarians.

Methods

Veterinarians from small domestic animal practices in Hong Kong were recruited using purposive and targeted snowball samplings until thematic saturation was achieved. Semi-structured in-depth interviews were conducted, audio-recorded, transcribed, coded, and analysed using reflexive thematic analysis with an interpretivist paradigm based on Heidegger’s phenomenological approach.

Results

A total of 18 participating veterinarians described the expectations of and communication with the animal-health enthusiast (AHE) community, including clients, pet owners, and animal lovers, as their primary source of stress. Discrepant expectations and miscommunication between the AHE and veterinary communities, along with contextual factors, such as convenience in clinic switching, negative online reviews, and the relatively short history of the veterinary profession in the multilingual city, were identified as contributing factors to their stress. Recent socio-political events and the pandemic further intensified societal emotions, leading some clients to project frustrations onto perceived authority figures, including health professionals.

Conclusion

The study highlights that client-related stress extends beyond the health of animal patients, encompassing the expectations of the AHE community, which requires professional-level communication skills to build a mutually respectful three-party relationship. Besides, Hong Kong’s unique contextual and historical factors subtly but chronically impact veterinary practices, which can be easily overlooked. Recognising these influences and how they interact is crucial for collaboration, within and beyond the profession, at the policy level to improve veterinary training and practices.

Implications

Our findings highlight the importance of expectation management and improving communication quality to foster healthy relationships among animals, the AHE community, and veterinary professionals. These efforts are believed to alleviate veterinarians’ stress and enhance the well-being of all parties involved. We recommend incorporating effective communication and self-care discussions into the veterinary curriculum and advocating ongoing training for practising veterinarians. At the community level, encouraging open dialogues between animal caregivers and veterinary professionals can help address expectation discrepancies.
Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal
Authors: Carvalho Paulo Tiago , Niza-Ribeiro João , Amorim Irina , Queiroga Felisbina , Severo Milton , Ribeiro Ana Isabel , Pinello Katia
Published: November 2023

Dogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were the aims of this study. HBC cases were obtained from North Regional Oncological Registry (RORENO) (2010–2015) and canine MGT cases from Vet-OncoNet (2019–2022). Analyses were performed based on published and well accepted classification systems (ICD-O-3.2 for humans and Vet-ICD-O-canine-1). Age-standardized incidence risks (ASIR) of Porto district municipalities were calculated using 2021 Portuguese census (INE) and data from the Portuguese animal registration system (SIAC). Among 7,674 HBC cases and 1,140 MGT cases, a similar age and sex distribution pattern was observed. Approximately 69.2% of HBC cases were between 40 and 69 years old, while 66.9% of MGT cases were diagnosed between 7 and 12 years old (mean age of 9.6 years, SD = 2.6). In women, Invasive breast carcinoma (8500/3) was the most common histological type (n = 5,679, 74%) while in dogs it was the Complex Carcinoma (8983.1/3) (n = 205, 39%). Cocker and Yorkshire Terriers exhibited the highest relative risks (3.2 and 1.6, p < 0.05, respectively) when compared to cross breed dogs. The municipalities' ASIR of the two species exhibited a high correlation (R = 0.85, p < 0.01) and the spatial cluster analysis revealed similar geographic hotspots. Also, higher ASIR values both in women and dogs were more frequently found in urbanized areas compared to rural areas. This research sheds light on the shared features and geographical correlation between HBC and canine MGT, highlighting the potential of cross-species environmental oncology studies.