bluuebunny/crossref_metadata_2025 huggingface dataset:
Transformation of the Video Game Phenomenon: From Hedonistic to Relevant Sociocultural Narrative
Authors:   Lipetsk State Pedagogical University named after P.P. Semenov-Tyan-Shan, Tarasov Alexey N. , Belyaev Dmitry A. ,   Lipetsk State Pedagogical University named after P.P. Semenov-Tyan-Shan
Published: September 2023

The work is focused on the transformation of video games in the socio-cultural space of modernity. It is shown that over the more than 60-year history of the existence of video games, in their socio-cultural purpose, they have gone from being a means of exclusively entertaining functionality to reflecting significant narratives of modern culture. The authors offer and substantiate an original periodization of this transformation process. A conventional boundary in the evolution of video games is shown by the set of factors/events of the late 1980s and early 1990s, when, according to the authors, video games, preserving their hedonistic orientation, began to overcome exclusively entertainment purpose, as from this moment actual socio-cultural narratives begin to be actively included in the video-game narrative. The entire set of identified factors/events contributing to this transformation is divided into two groups - technological (internal) and sociocultural (external). The second part of the paper analyzes specific examples of socio-cultural practices of modernity, confirming that video-game reality has already gone beyond the scope of entertainment functionality and, by broadcasting an actual socio-cultural narrative, contributes to the transformation of the modernity discourse in the perception of the average person.
La agencia en la sociología de Pierre Bourdieu y Anthony Giddens
Authors: Giovine Manuel Alejandro , Barri Juan
Published: September 2023

La noción de agencia ha tenido un impacto indiscutible en la teoría sociológica contemporánea. Sin embargo, es poco lo que se ha reflexionado acerca de las potencialidades y las limitaciones epistemológicas de este concepto para la acción estratégica del sujeto. Este artículo presenta dichas potencialidades y limitaciones en las perspectivas de Pierre Bourdieu y Anthony Giddens, en tanto instrumento cada vez más relevante para explicar y comprender la acción social y los sentidos y significados implicados en ella. Simultáneamente, muestra la importancia de este concepto para dar cuenta del alcance del proceso reflexivo en la elección estratégica del sujeto (individual o colectivo), que es quien en definitiva produce y reproduce la sociedad por medio de sus prácticas.
House of the Dragon (2022). Política, plataformas y cultura mainstream
Authors: Sánchez María Lucía
Published: September 2023

El presente artículo se aborda la serie de televisión House of the Dragon (HBO, 2022), para dar cuenta de su contexto de producción y de circulación. Para esto, se considera, por un lado, un eje de análisis vinculado con la descripción de los sentidos respecto de la cultura mainstream, el capitalismo de plataformas y la masividad de los públicos; por otro lado, se indagan los vínculos entre las categorías de lo político y la política para pensar de qué manera el discurso ficcional está en diálogo con sentidos, representaciones y problemáticas actuales.
Imagen oficial vs intervención urbana efímera. Diálogo y yuxtaposición como figuras de la complejidad en el espacio público
Authors: Garduño Oropeza Gustavo
Published: September 2023

La perspectiva teórica sobre el carácter complejo e hipercultural que encuadrará al caso a estudiar en el presente texto: el de la relación que se da entre lo que denominaremos “imagen oficial”, entendida como el conjunto de manifestaciones gráficas legitimadas por un orden institucional o corporativo y su esfuerzo por contrarrestar la emergencia de “intervenciones anónimas y efímeras” entendidas como mera vandalización, protesta o denuncia por parte de aquellos que han quedado al margen o segregados del continuo desarrollista. Para ello se relaciona el término “ciudad” con la idea de contexto hipercultural, en cual que emerge una amalgama de sentidos complejos a ser catalizada por parte de instituciones a partir de la producción de identificadores comunes.
Nadezhda Krúpskaya y la interseccionalidad de género: invisibilización de los aportes de la mujer y de la educación rusa en occidente
Authors: Castro Val Dulce María
Published: September 2023

El objetivo del presente trabajo es abordar desde los planteamientos de la complejidad, en particular las orientaciones de Basarab Nicolescu sobre los múltiples niveles de realidad, algunas de las afectaciones sufridas por mujeres como Krúpskaya, con lo que se propone la posibilidad de analizar y exponer la interseccionalidad de género y el relato histórico patriarcal como una forma de reivindicación de figuras de gran trascendencia, pero que han “desaparecido” de dicho relato, esto bajo la consideración de que la perspectiva de la complejidad permite una mejor comprensión del fenómeno. Por otro lado, visibilizar la interseccionalidad implica reflexionar sobre las consecuencias a nivel social en términos de la normalización del papel de la mujer como personaje secundario (en el mejor de los casos), para con ello construir otro tipo de relatos desde perspectivas menos sesgadas.
Inclusion of disabled immigrants/refugees in the Greek educational system: Views of primary school teachers
Authors: GİAVRİMİS Panagiotis
Published: September 2023

In recent decades, there has been a systematic academic research attempt to analyze issues related to disability. Although disabled people are an essential group of migrants and refugees, and international conventions protect their social inclusion, it is noticeable that migration studies have not dealt with persons with disabilities until recently. The corresponding disability studies do not study the group of migrant/refugee-disabled persons. This study aims to research the teachers' views of the N. Aegean region on including disabled migrants and refugees and the educational policies implemented. A semi-structured interview was the research tool used for this study. The participants in the study were twenty-three primary school teachers. The teachers in our research pointed out that the right of disabled migrants to be included in education is lost in the context of evaluation criteria, inadequate educational policies and the fear of individuals resisting the dominant discourse of ableism and hyper-socialised reality.
Foreign Policy Preferences of Kazakhstan after 2022
Authors: Kucherov M. Y. , Vokhmintsev I. V. , Kravchuk I. D. , Andriukhin V. Y. , Fedotov M. A. , Tokarev A. A.
Published: September 2023

The January 2022 protests in Kazakhstan drew global attention to the country's foreign policy orientations. This research investigates the focal states and international organizations prioritized by Kazakhstan during Kassym-Jomart Tokayev's presidency, spanning from March 20, 2019, when Tokayev assumed office, to December 31, 2022, marking the end of data collection. Employing content analysis and discourse analysis as primary methods, this study examines data from diverse sources, including the official website of Kazakhstan's President, his social media profiles, and relevant media outlets. The analysis encompasses mentions of countries, their leaders, and international organizations across three languages: Russian, Kazakh, and English.

Key findings include Tokayev's frequent references to Russia (223 mentions) and China (95 mentions), while the United Nations (UN) and the Eurasian Economic Union (EAEU) receive the highest number of mentions among international organizations (178 and 102, respectively). Remarkably, Tokayev predominantly communicates in Russian when addressing foreign policy matters.

In general, public discourse aligns closely with Kazakhstan's doctrinal discourse. However, notable discrepancies arise. Despite the Foreign Policy Concept's indication of Kazakhstan's intent to strengthen its strategic partnership with the United States, Tokayev's limited mentions of the United States (33 in total) suggest a distinct trend.
Pertumbuhan Kembali dan Hasil Asystasia gangetica Subsp. Micrantha yang Diberi Pupuk Organik Limbah Padat Virgin Coconut Oil dengan Dosis dan Waktu Dekomposisi Berbeda
Authors: Tarigan Efraim Primsa , Duarsa M. Anuraga Putra , Witariadi N. M.
Published: September 2023

ABSTRAK 

Penelitian bertujuan untuk mengetahui pengaruh serta interaksi antara waktu dekomposisi dan dosis pupuk organik limbah padat virgin coconut oil (VCO) terhadap pertumbuhan kembali dan hasil Asystasia gangetica subsp. Micrantha. Penelitian dilakukan di Rumah Kaca, Stasiun Penelitian Sesetan, Fakultas Peternakan, Universitas Udayana di Jalan Raya Sesetan Gang Markisa. Penelitian berlangsung selama 2 bulan, menggunakan rancangan acak lengkap (RAL) pola faktorial. Faktor pertama adalah waktu dekomposisi: 4 minggu (W4), 2 minggu (W2), dan 0 minggu (W0) dan faktor kedua terdiri atas dosis pupuk organik limbah padat VCO yaitu: 0 ton ha-1 (D0), 10 ton ha-1 (D10), 20 ton ha-1 (D20), dan 30 ton ha-1 (D30). Terdapat 12 kombinasi perlakuan dan setiap perlakuan diulang sebanyak empat kali sehingga terdapat 48 unit percobaan. Variabel yang diamati yaitu variabel pertumbuhan, variabel hasil, dan variabel karakteristik tumbuh tanaman. Hasil penelitian menunjukkan bahwa terjadi interaksi antara waktu dekomposisi dan dosis terhadap semua variabel kecuali variabel tinggi tanaman dan jumlah daun. Waktu dekomposisi 4 minggu dan 0 minggu memberikan respon lebih baik dibandingkan waktu dekomposisi 2 minggu. Dosis terbaik terhadap pertumbuhan kembali dan hasil A. gangetica yaitu 20 ton ha-1. Disimpulkan bahwa terjadi interaksi antara waktu dekomposisi dan dosis serta perlakuan waktu dekomposisi 4 minggu dan dosis 20 ton ha-1 memberikan respon terbaik pada pertumbuhan kembali dan hasil A. gangetica subsp. Micrantha. 

Kata kunci: Asystasia gangetica, dekomposisi, dosis, hasil, limbah padat VCO, pertumbuhan kembali
Kandungan Mineral Hijauan Berbagai Aksesi Arbila (Phaseolus lunatus L.) dari Biji Berkategori Berat sebagai Pakan di Kabupaten Kupang
Authors: Koten Bernadete Barek , Balan Yejida Soleman , Wea Redempta , Vertigo Storming , Dato Twen Dami , Lestari I G. A. Y. , Titong Allan Prima
Published: September 2023

ABSTRAK 

Tujuan penelitian adalah untuk mengevaluasi kandungan mineral hijauan berbagai aksesi Arbila (Phaseolus lunatus L.) dari biji berkategori berat sebagai pakan dari Kabupaten Kupang dilaksanakan selama 5 bulan (Mei – September 2022) di lahan Hijauan Pakan Politani Negeri Kupang. Benih Arbila yang digunakan sebanyak 10 aksesi. Variabel yang diamati: kadar kalsium (Ca) (%), fosfor (P) (%) dan kalium (K) (%). Data dideskriptifkan. Hasil menunjukkan bahwa hijauan Arbila yang berasal dari biji dengan berkategori berat mengandung 1,66% - 3,56% Ca, 0,37% - 0,64% P dan 1,48% - 1,91% K. Dari 10 aksesi, 20% nya dengan kadar Ca > 3% (K3 dan K5), 50% dengan kadar Ca 2,5 - 3% (K1, K4, K7, K8, dan K9), dan di bawah 2,5% terdapat 30% (K10, K11, dan K13). Hijauan dengan kadar P > 0,5% sebanyak 40% (K4, K5, K7, dan K9), dan < 0,5% sebanyak 60% (K1, K3, K8, K10, K11, dan K13). Kadar K hijauan > 1,5% sebanyak 70% (K3, K4, K5, K9, K10, K11, dan K13), dan sebanyak 30% (K1, K7 dan K8) yang mengandung K < 1,5%. Disimpulkan bahwa hijauan yang berasal dari biji Arbila berkategori berat mempunyai kadar Ca dengan kisaran 2,43% - 3,58%, kadar P 0,42% - 0,56% dan kalium 1,18% -1,83%. Hijauan Arbila dari aksesi K5 mempunyai kadar Ca dan K yang tertinggi dan K4 mempunyai kadar P tertinggi. 

Kata kunci: kandungan mineral hijauan, aksesi arbila (Phaseolus lunatus L.), biji berkategori berat, kalsium, fosfor
فاكتەرێن پيادەكرنا كەلتوورى د ڕۆمانێن (محمد سليم سوارى)دا
Authors: Rafat Abozaid Mardan , Saeed Zozan Sadeq
Published: September 2023

كەلتوور دبيتە بنياتەك نڤێسەر بەرهەمێ خۆ يێ دەستپێكى ل سەر ئاڤابكەت. ڕۆمانڤێس ژبۆ دياركرنا لايەنێ ڕەسەنايەتيێ دناڤ مللەتيدا پەنايێ دبتە بەر لايەنێ كەلتوورى كو مەبەستا وى ئەوە نەوەيێ داهاتى ئاشنايێ كەلتوورێ خۆ بن. كو ئەڤ ڤەكۆلينە ل ژێر ناڤێ (فاكتەرێن پيادەكرنا كەلتوورى د ڕۆمانێن "محمد سليم سوارى"دا).  كو مەبەستا ژ ئەڤێ ڤەكولينێ ئەوە كو لايەنێ كەلتوورى دناڤ رومانێن ناڤبريدا دياربكەن. ئەڤ ڤەكۆلينە هەولددەت ئەوان فاكتەران دياربكەت ئەوێن ڕۆمانڤێس (محمد سليم سوارى) پالداى كو ب ڕێكا ئەوان كەلتوور د ڕۆمانێن خۆدا بكاربهينت.
بنياتێ زمانى د چيرۆكێن زارۆكاندا ل دەڤەرا بەهدينان
Authors: Saleem Shaimaa Saleem , Saeed Zozan Sadeq
Published: September 2023

زمان  هوكارەكێ گرنگە ژ بۆ لێك تێگەهشتنێ دناڤبەرا دوو كەساندا دهێتە ئالوگوركرن، و كەرەستێ پێشكەڤتنا گشت ميللەت و نەتەوەيێن جيهانێيە، گرنگيەكا مەزن د ژيانا مرۆڤيدا هەيە، مرۆڤ دشێت زمانى ب رامانا بەرفرەهكرنێ بكاربهينيت. ئەڤ ڤەكولينە ل ژێر ناڤێ "بنياتێ زمانى د چيرۆكێن زارۆكاندا ل دەڤەرا بەهدينان" لايەنێن زمانى ئەوێن دناڤ چيرۆكێن زارۆكاندا هاتينە پيادەكرن بهێنە بەرچاڤكرن، پەيڤێن سەرەكى ( بنياتێ زمانى، چيرۆكێن زارۆكان، دەڤەرا بەهدينان).
Digitalization in the Middle East: a Threat to the Regional Security or a Way to maintain it?
Authors: Ilina Elizaveta Vladimirovna , Chipizubova Polina Andreevna
Published: September 2023

The article is devoted to the main threats and advantages brought by digitalization in the Middle East nowadays. The research problem of the article is "which influence of digitalization – positive or destructive – prevails in the Middle East and what prospects await this region in the digital sphere. The interests of key regional players in the cybersphere (Saudi Arabia, the UAE, Turkey, Iran, etc., as well as anti-systemic non-state actors), as well as regional and national initiatives in this industry, including "Peninsula Shield", "Vision 2030" and others, are analyzed. The scientific novelty of the study lies in a non-classical approach to security problems in the Middle East, namely through the prism of the digital sphere, taking into account its complexity and the multiplicity of its actors. The theoretical basis of the research is based on a neoliberal approach to world politics, in particular, on the concept of complex interdependence, since the authors rely on the postulate that the world policy sphere is inextricably linked with others, and also consists of a multitude of heterogeneous actors and connections between them. From the point of view of studying regional integration in the Middle East, the dominant approach is neofunctionalism, developed by E. Haas, in particular, the theory of "spillover". The research methods used are description, study of official documents and statistical data, situational analysis, comparative analysis, which made it possible to assess the key threats and prospects for regional security and their correlation. The authors conclude that the key threat to the region is the disunity of the main actors' interests and the associated possibility of political contradictions' aggravation. Nevertheless, digitalization provides the Middle East with such advantages as deepening regional integration and inclusion in international cooperation, the growth of soft power and the potential for economic diversification.
Effect of Thermal Nonequilibrium on Captured Mass Flow Rate of Scramjet Inlets
Authors: Wu You , Liu Jiwu , Peng Jian , Xu Xu , Chen Bing , Yang Qingchun
Published: September 2023

The numerical simulation of a scramjet is often based on the thermal equilibrium model, but the flow inside the inlet and isolator is likely to be in thermal nonequilibrium due to shock-based compression. The objective of this study is to investigate the effect of thermal nonequilibrium on the mass flow rate captured by the scramjet inlet. Numerical simulations based on the thermochemical nonequilibrium model (thermal nonequilibrium) and the chemical nonequilibrium model (thermal equilibrium) were adopted to study the mass flow rate of the HyShot II scramjet with the incoming flow Mach numbers [Formula: see text] ranging from 6.0 to 8.0. The results show that the maximum difference of the mass flow rate between thermal nonequilibrium and equilibrium reaches 10.7% at [Formula: see text] with [Formula: see text]. The primary cause of the mass flow rate difference is the oblique shock wave angle difference between nonequilibrium and equilibrium. The relative magnitudes of oblique shock wave angles and flow parameter ratios across the wave under equilibrium and nonequilibrium are theoretically discussed in an intuitive way. A simplified model for the HyShot II is established to predict the mass flow rate difference between thermal nonequilibrium and equilibrium. The result shows that the expression of captured mass flow rate has a significant amplification effect on the slight difference of wave angles between thermal nonequilibrium and equilibrium, which means that the effect of thermal nonequilibrium cannot be ignored for scramjet in some cases.
Trabalho em equipe durante a pandemia: observando a realidade na Atenção Primária à Saúde
Authors: Rodrigues Onadja Benício , Resende Marina Cleia de , Guedes Brenda Lavínia Calixto dos Santos , Dias Danilo Erivelton Medeiros , Silva Suenildo Messias da , Alves Fabiana Paulino , Cabral Ana Maria Barbosa , Barbosa Amandda Thaise de Souza , Franco Richele Teixeira de Lima , Silva Francisco Ranilson Alves
Published: September 2023

Objetivo: Elucidar o desenvolvimento do trabalho em equipe durante a pandemia da COVID-19. Métodos: Estudo teórico, tipo revisão integrativa da literatura, realizada entre Novembro de 2022 a Janeiro de 2023, na fonte de dados Biblioteca Virtual em Saúde (BVS) e nas bases de dados do portal CAPES, através do acesso CAFe, utilizando os descritores validados pelo DeCS/MeSH; Trabalho em equipe, Atenção Primária à Saúde e COVID-19, com os filtros texto completo e disponível, documentos tipo artigos científicos; ano de publicação 2020 a 2022, realizados no idioma português. A população da pesquisa incluiu 40 artigos. Após leitura de seus resumos, foram selecionados 12 artigos. Resultados: O trabalho em equipe proporciona a efetiva prática colaborativa, que otimiza os serviços de saúde, fortalece os sistemas e redes de atenção à saúde e incita melhorias de resultados na qualidade da assistência, tanto nas intervenções voltadas às condições agudas, como na APS. As evidências demonstram que pacientes relatam maior grau de satisfação, melhor aceitação e melhoria de resultados. Considerações finais: É preciso modificar os procedimentos e ações de trabalho dos profissionais de saúde, neste caso relacionados à atenção primária à saúde, para que as relações entre equipes de saúde e usuários sejam sólidas.
Diabetes mellitus induzido pelo uso de glicocorticoide
Authors: França Ana Meirellen Souza , Mançur Bruna de Macedo Brigth , Carvalho Evile Brito , Matos Malu Landi , Marques Matheus Santos
Published: September 2023

Objetivo: Analisar o diabetes mellitus induzido por corticoides. Métodos: Trata-se de uma revisão integrativa, por meio de buscas nas bases de dados científicas PubMed, BVS e LILACS, onde foram selecionados 9 artigos no PubMed, 6 artigos na BVS, 1 artigo na LILACS, totalizando 16 artigos. Resultados: O diabetes mellitus é uma doença crônica caracterizada como um grupo heterogêneo de alterações a nível metabólico, que são resultados de quadros sustentados de hiperglicemia, ocasionada, sobretudo, por déficits na ação da insulina, na secreção deste hormônio ou, em algumas situações, de ambos os defeitos.  Com isso, o diabetes e a hipertensão foram as toxicidades cardiometabólicas com maior frequência a partir de padrões de exposição aos variados glicocorticoides, de acordo com a doença de subjacente, ao passo que s corticosteroides inalatórios e os ß-agonistas inalatórios dispensados foram associados a um risco aumentado de diabetes tipo 1 após ajuste para outros medicamentos antiasmáticos, asma, sexo e década de nascimento. Considerações finais: Portanto, o uso de corticoides em um amplo espectro de doenças, a depender da dose, do tempo de exposição e gravidade da doença de base, podem induzir o surgimento de diabetes mellitus.
The Prevention Efforts of the Adverse Impact of Abrasion and Tidal Flooding and Effects on the Economic and Social Resilience
Authors: Kurniadi Anwar , Maarif Syamsul
Published: September 2023

The impact of coastal abrasion and tidal flooding will disrupt public security and community welfare, especially economic and social resilience. There must be efforts to prevent adverse impacts so that there is no decrease in economic and social resilience. This study uses a qualitative method with a descriptive design. The purpose of this study was to analyze the effect of the efforts of preventing the adverse impact of coastal abrasion and tidal flooding on economic and social resilience on the coast of Bekasi, West Java. The research was conducted from April 2022 to December 2022 with 15 informants. The results of the study were: a) the efforts of preventing the adverse impact were engaging the community, comprehensive vegetation mitigation training, changing the procedure for planting mangrove forests, developing fruit yields and developing a mangrove program as a prospective project; b) the effects on the economic resilience of community are still able to meet their daily needs even though they experienced a decrease in daily income. The community is still implementing social interaction and cooperation well and also they still help each other and do not want to move to other locations. The community still has a high level to maintain economic and social resilience.
Assessment of Seismic Vulnerability of School Buildings: A case study in Bandung, West Java, Indonesia
Authors: Milyardi Roi , Desiani Asriwiyanti , Wong Hendry , Setiawan Deni , Husada Ginardy
Published: September 2023

Indonesia is an earthquake-prone country. In many earthquakes, school buildings suffer the most damage than other public facilities. In 2020, the conditions of around 70% of 218,234 school classrooms in Indonesia were deteriorating. This contributed to a significant earthquake vulnerability. Limited funding for rehabilitation and renovation became an obstacle to reduce the vulnerability. This study proposed that Rapid Visual Screening (RVS), which is a simple method and has a wide coverage, could be a solution to prioritize building rehabilitation. Bandung, the capital city of the most populated province in Indonesia, has complex earthquake hazard risks, which made it a suitable study area for implementing RVS. This study conducted a seismic vulnerability assessment of school buildings in the city of Bandung, Indonesia. The methodology used is based on Indonesia National Disaster Management Agency (BNPB)’s Regulation No. 4 of 2012 on Rapid Visual Screening (RVS) procedure compared to FEMA 154 RVS procedure with local hazard data and building data. RVS was conducted in total 334 elementary school buildings in 30 districts. The result of the BNPB’s RVS procedure showed an average RVS score (S) of 4.455 where 36.53% buildings were in safe condition and 63.47% buildings required further assessment of the conditions from construction experts. The result of the FEMA 154 RVS procedure showed an average RVS score (S) of 0.905 where 22.16% of the buildings were in high probability of grade 4 damage and 77.84% of the buildings were in high probability of grade 3 damage.
Landslide Investigation through Emerging Technology of Electrical Resistivity Tomography
Authors: Sudani Prashant , Patil K.A.
Published: September 2023

A landslide is an event of a disaster and has adverse effects on every country with varying degrees of impact. The lithology's complex nature, the vast slide area and the landslide's topography make the direct investigation challenging. In depth landslide investigation demands multidisciplinary knowledge, skilled human power and costly testing equipment, making direct investigation tedious and time-consuming. However, an alternative for the direct investigation is needed to cover all the aspects of landslide mechanism. Recently advanced geophysical methods have an excellent potential for collecting landslide mechanism-related information without disturbing them. One such method is effectively used to investigate the soil's subsurface properties as one of the significant threats to stability is rainfall in a landslide-prone area and its resolve is effectively called Electrical Resistivity Tomography (ERT). The present study endeavors to display cutting-edge research on the applications of Electrical Resistivity Tomography (ERT) in the field of landslide investigation. The foremost objective of the study is to present the outcomes of geophysical surveys conducted through ERT, which encompass 1D, 2D, 3D and time-lapse investigations. The study also highlights the advantages and limitations of these ERT investigations and identifies potential challenges that need to be addressed for the optimum utilization of ERT in future research.
Formulation and Evaluation of herbal preparation containing multiherb for hypocalcaemia
Authors: Mali Dhanashri R. , Amrutkar Sunil V. , Yeole Namrata R.
Published: September 2023

Calcium is a necessary vitamin for human health. It helps the body create strong bones and teeth. It is required for the correct functioning of heart and other muscles. Calcium shortage, known as hypocalcemia, is a disorder in which a person's blood calcium levels are abnormally low. Women must begin to increase their calcium consumption earlier in life than males. As a woman approaches menopause, it is especially vital to meet her calcium requirements. Calcium homeostasis is important for supporting human life functions like skeleton maintenance, hormone secretion regulation, nerve impulse transmission and vascular activity. Herbs with a high calcium content may aid in maintenance of calcium levels in the body. Though various supplements are available to address calcium shortage, herbal formulations are recommended since they have fewer side effects and are less expensive. This research focuses on the use of herbal plants to treat hypocalcemia. This study aimed to produce and test herbal candies that contained these herbs and used as natural excipients. Drumstick (Moringa oleifera), shingada (Trapa natans), hadjod (Cissus quadrangularis) and finger millet (Eleusine coracana) are among the ingredients in the formulation that will help with hypocalcemia. Organoleptic and other screening test are used to evaluate formulation. Calcium content was determined by the EDTA method and Atomic absorption spectroscopy.
Validation of antioxidant activity and cytotoxic potential of Protium caudatum leaves extract against lung cancer cell line (A549)
Authors: Selvaraj Dinesh , Yadav Sangilimuthu Alagar , Suvathika Gnanaselvan , Sowmya Manoharan Priya
Published: September 2023

Antioxidants play key role in health modulatory effects. Intake of antioxidants improves immunity which works against free radicals. In the study, the fractionated alcoholic extract of Protium caudatum leaves was subjected to phytochemical screening, estimation of phenolics and flavonoid content, anti-oxidant activity and cytotoxicity activity against lung cancer cells (A549 cells). The ethanolic extract of P.caudatum has high antioxidant efficiency through DPPH and ABTS assay and L-ascorbic acid was used as standard. The cytotoxicity analysis was performed with MTT assay against lung cancer cell line (A549 cells). The phytochemical screening test shows the presence of carbohydrates, alkaloids, flavonoids and tannins. Total phenolic and flavonoid content of P. caudatum exhibited 20μg/g and 15μg/g respectively. The DPPH and ABTS showed the IC50 values such as 38.50 ± 0.01 μg/ml and 24.34 ± 0.03 μg/ml for sample and 13.5 ± 0.02 μg/ml and 11.3 ± 0.1 μg/ml for standard respectively. Cytotoxicity in MTT analysis of Protium caudatum leaves revealed the IC50 value as 63 ± 0.05 μg/ml against A549 cell line with standard 5 fluorouracil. With this significant inference ethanolic fraction of P. caudatum shows the potent antioxidant and cytotoxic activity paving the way to identify the active phytoconstituents and mode of action of the molecules to be studied.
Using Ethanol Degradation as Accelerated Chemical Seed Ageing Indicator For Different cultivars of Soybean
Authors: SHINTARIKA Feni , PERKASA Achmad Yozar , FADHILLAH Siti Rahmatika
Published: September 2023

Indonesia has a wide range of swampy lands that need to be recovered for safe agriculture. The swampy lands and vegetation are a source of soil contamination through root exudates that need serious improvement. The plant exudates in soil could disturb seed germination. This study aimed to determine the effect of ethanol vapor treatment on the decrease in the vigor of four soybean seed cultivars. This study used a randomized block design with two treatment factors, namely ethanol-based ageing treatments as the main factor and cultivars as subfactor. The observation variables consisted of the percentage of germination, growth rate, vigor index, sprout length and sprout dry weight. The results showed that there was an interaction effect between fast ageing time and ethanol treatments and soybean cultivars which caused a decrease in the seed vigor. The soybean seeds of the cv. Gema was able to maintain more vigor compared to the cv. Grobogan which experienced more decline in germination. The 5 minutes of ageing time induced fewer damages with the highest vigor while 20 minutes of ageing the seeds induced maximum damage with the lowest seed vigor.
La dyspraxie, un trouble développemental de la coordination
Authors: Lambert Salomé , Viali Julie
Published: September 2023

La dyspraxie, un trouble développemental de la coordination
« Comment soigner une hystérique ? » L’évolution des perceptions et de la prise en charge clinique du trouble dissociatif
Authors: Bruttin Cloé , Maamo Marina
Published: September 2023

« Comment soigner une hystérique ? » L’évolution des perceptions et de la prise en charge clinique du

trouble dissociatif
La soumission chimique par GHB dans les milieux festifs nocturnes : qu’est-ce que c’est ?
Authors: Morais Da Rocha Vanessa , Voisin Maëlys
Published: September 2023

La soumission chimique par GHB dans les milieux festifs nocturnes : qu’est-ce que c’est ?
MIO : De la compréhension à l’accompagnement cognitif et affectif des élèves
Authors: Theuvenat Claire-Lise
Published: September 2023

Cette « Perspective » présente un projet pilote de l’application de l’outil MIO « Modèle Interne Opératoire » adapté et enseigné par Fahim, C. (2021) au CAS en neurosciences de l’éducation à l’Université de Fribourg entre 2021-2022. Quelle réponse puis-je apporter à ma question de départ : « L’outil MIO permet-il aux élèves que j’accompagne de mieux identifier et verbaliser leurs émotions, et favorise-t-il une diminution de leur stress et l’acquisition d’un certain calme voire d’une sécurité affective ? » Les résultats préliminaires montrent que la réponse est « oui ». Cependant, plus d’études de l’outil MIO sont requises afin de valider ces conclusions. La théorie et la documentation étudiée pour mon projet conforte ma conviction de l’efficacité de l'outil MIO, cependant comme je l’ai souligné au départ l’évaluation des retombées nécessite une durée d’application sur un plus long terme. De plus, diverses contraintes telles que l’organisation du camp de début d’année scolaire, vacances scolaires d’automne, organisations internes ou encore absences des élèves pour cause de maladie ont fait que j’ai manqué de temps et n’ai pu, dès lors réaliser l’ensemble des activités MOI sur une année scolaire. En conclusion, les enfants ont exprimé leur plaisir à participer aux ateliers MIO et ont su faire, sur le moment, des liens avec leur quotidien. J’en profite ici pour les féliciter pour leur implication et les remercier pour leur tolérance vis-à-vis de mon manque d’expérience quant au contenu et à l’utilisation de cet outil que je découvrais presque en même temps qu’eux.
Diastereoselective Synthesis of 2-Amino-1-Pyrrolines via Gold-Catalyzed N-Alkenylation of Isoxazolines and Rearrangement
Authors: Alshreimi Abdullah S. , Zhang Guanqun , Shim Esther , Wink Donald J. , Anderson Laura L.
Published: September 2023

The gold-catalyzed synthesis of 2-amino-1-pyrrolines from isoxazolines and ynamides has been explored as a retrosynthetic alternative to conventional approaches that overcomes traditional limitations and expands the structural diversity of these important heterocycles. Optimization of gold-catalyzed C–N bond formation and subsequent rearrangement is described in addition to reaction scope and methods for the preparation of NH-isoxazolines. Mechanistic insight into the rearrangement pathway is discussed and supports the observed control of relative stereochemistry. The use of chiral auxiliaries for the preparation of chiral non-racemic 2-amino-1-pyrrolines is also examined.
Carbon Bond Catalysis: Dialkyl Sulfates, Alkyl Sulfonates and Alkyl Hal-ides as Catalysts in Acetal Forming and Related Reactions
Authors: Goreti Rajendar , Sarkar Tanmay , R. S. Reyno , S Keerthana
Published: September 2023

This study demonstrates a previously unexplored facet of sp3-carbon electrophiles (or alkylating agents): their potential for catalytic applications through carbon-bond interactions. In contrast to their classical SN1 and SN2 reactions, we present an al-ternate perspective, the catalytic nature of alkyl electrophiles through noncovalent interactions (NCIs). The involvement of NCIs by carbon electrophiles (possessing polar Csp3-X bonds) in stabilizing conformations of small molecules and biomole-cules has recently been discovered. Nevertheless, their catalytic role in activating small molecules has not been observed. As the "X" group evolves into an effective leaving group, carbon electrophiles develop strong positive potentials on the carbon surface (σ-hole). However, small atomic size and steric congestion resulting from the presence of four groups around the carbon atom pose challenges in establishing strong σ-hole interactions with nucleophilic acceptors. This unique behavior of alkyl electrophiles has deterred chemists from exploring their potential as catalysts in chemical transformations. In groundbreaking revelation, we demonstrate for the first time that alkyl electrophiles function as Lewis acid catalysts in activating carbonyls for acetal formation and related reactions through NCIs. We meticulously chose a range of alkyl electrophiles and discovered a striking correlation between their molecular electrostatic potential (MEP) surface energies and their catalytic efficacy in acetal-forming reactions. Our comprehensive approach, which encompassed both experimental and theoretical investigations, provided robust support for the catalytic potential of alkyl electrophiles through non-covalent carbon bond interactions.
Direct Calculation of Electron Transfer Rates with the Binless Dynamic Histogram Analysis Method
Authors: Koczor-Benda Zsuzsanna , Mateeva Teodora , Rosta Edina
Published: September 2023

Umbrella sampling molecular dynamics simulations are widely used to enhance sampling along the reaction coordinate of chemical reactions. The effect of the artificial bias can be removed using methods such as the Dynamic Weighted Histogram Analysis Method (DHAM), which in addition to the global free energy profile also provides kinetic information on barrier-crossing rates directly from the Markov matrix. Here we present a binless formulation of DHAM, which extends DHAM to high-dimensional and Hamiltonian-based biasing, allowing the study of electron transfer (ET) processes, where enhanced sampling is usually not possible based on simple geometric grounds. We show the capabilities of binless DHAM on examples such as aqueous ferrous-ferric ET and intramolecular ET in the radical anion of benzoquinone–tetrathiafulvalene–benzoquinone (Q-TTF-Q)–. From classical Hamiltonian-based umbrella sampling simulations and electronic coupling values from quantum chemistry calculations, binless DHAM provides ET rates for adiabatic and nonadiabatic ET reactions alike, in excellent agreement with experiment.
Nickel-Bound 5-Membered N-Heterocyclic Arynes: Access to Previously “Inaccessible” 7-Aza-2,3-indolynes
Authors: Humke Jenna , Belli Roman , Plasek Erin , Kargbo Sallu , Ansel Annabel , Roberts Courtney
Published: September 2023

N-Heteroaromatics are key elements of life-saving pharmaceuticals, potent agrochemicals, and vital materials. N-Heteroarynes provide a scaffold to build these essential molecules but are underutilized because 5-membered N-heteroarynes have been computed to be inaccessible to synthetic chemists due to the strain of a triple bond in a 5-membered ring. Using principles of metal-ligand interactions that are foundational to organometallic chemistry, herein is reported the first access to a previously inaccessible 5-membered N-heteroaryne. A series of 1,2-bis(dicyclohexylphosphino)ethane nickel 7-azaindol-2,3-yne complexes are synthesized and characterized crystallographically and spectroscopically. In order to showcase the synthetic potential, a difunctionalization of N-methyl-7-azaindol-2,3-yne to form two new C-C bonds is performed. By overcoming a 120-year old limitation, we have unlocked a new synthon for the synthesis of difunctionalized N-heteroaromatics for transformative synthesis.
Revealing the Formation Dynamics of Janus Polymer Particles: Insights from Experiments and Molecular Dynamics.
Authors: Nedyalkova Miroslava , Loche Philip , Russo Giovanni , Lattuada Marco
Published: September 2023

Seeded emulsion polymerization is one of the best-known methods for preparing polymer particles with controlled size, composition, and shape. It first requires the preparation of seed particles, which are then swollen with additional monomer (the same as the one used for the seed or a different one), to either increase the seed's size or change its morphology. The use of surfactants plays a central role in guaranteeing the required colloidal stability and contributing to the final shape and structure of the particles by lowering the interfacial energy between the polymer of the seed and the added monomer. We here study the polymerization of methyl methacrylate in the presence of polystyrene seed particles at various surfactant concentrations, in the presence and absence of a surfactant (sodium dodecyl sulfate). We first show experimentally that the morphology of the colloidal particles can be tuned from Janus to core-shell, depending on the presence or absence of surfactant on the seeds particles’ surface. Furthermore, using classical molecular dynamics simulations, we investigate the mechanism and behavior of surfactants during the first stages of the polymerization process. We use a newly developed approach based on contact statistical analysis to confirm the critical role played by the organization of surfactant molecules on the seed particles’ surface in dictating the final particle morphology.
Electron density mapping of boron clusters via convolutional neural networks to augment structure prediction algorithms
Authors: Saha Pinaki , Nguyen Minh Tho
Published: September 2023

Determination and prediction of atomic cluster structures is an important endeavor in the field of nanoclusters and thereby in materials research. To a large extent the fundamental properties of a nanocluster including its chemical, optical, magnetic, mechanical and transport properties are mainly governed by the molecular structure it adopts. Traditionally, structure elucidation is achieved using quantum chemical (QC) calculations that are usually tedious and time consuming for large size clusters. Various structural search algorithms, implemented in software codes, have been reported in the literature. Although they tend to accelerate the structure exploration, they still require the aid of QC calculations of energies for structure evaluation. This makes the structure prediction process using these approaches a computationally expensive affair. In this paper, we report on the creation of a convolutional neural network model based on a machine learning, which can give relatively accurate energies for the ground state of nanoclusters from the total electron density on the fly and could thereby be utilized for aiding structure prediction algorithms. We have built up a dataset consisting of pure boron clusters for the purpose of training our model.
Reaction Mechanism of Hydrogen Generation and Nitrogen Fixation at Carbon Nitride/Double Perovskite Heterojunctions
Authors: Malavasi Lorenzo , Tedesco Costanza , Profumo Antonella , Speltini Andrea , Merlo Francesca , Mosconi Edoardo , De Angelis Filippo , Kaiser Waldemar , Alothman Asma , Listorti Andrea , Colella Silvia , Gregori Luca , Saba Michele , Simbula Angelica , Pitzalis Federico
Published: September 2023

Photocatalytically active heterojunctions based on metal halide perovskites (MHPs) are drawing significant interest for their chameleon ability to foster several redox reactions. The lack of mechanistic insights into their performance, however, limits the ability of engineering novel and optimized materials. Herein, we report on a composite system including a double perovskite, Cs2AgBiCl6/g-C3N4, used in parallel for solar-driven hydrogen generation and nitrogen reduction. The composite efficiently promotes the two reactions, but its activity strongly depends on the perovskite/carbon nitride relative amounts. Through advanced spectroscopic investigation and density function theory modelling we studied the H2 and NH3 production reaction mechanisms, finding perovskite halide vacancies as the primary reactive sites for hydrogen generation, withstanding a positive contribution of low loaded g-C3N4, in reducing carrier recombination. For nitrogen reduction, instead, the active sites are g-C3N4 nitrogen vacancies, and the heterojunction best performs at low perovskites loadings, as the composites maximizes light absorption and reduced carrier losses. We believe these insights are important add-ons towards universal exploitation of MHPs in contemporary photocatalysis.
Quantifying and modulating protein encapsulation in guanosine-based supramolecular particles
Authors: Prieto-Costas Luis A. , Rivera-Cordero Génesis R. , Rivera Jose M.
Published: September 2023

The encapsulation of proteins is an effective way to preserve their structure and enhance their function. One exciting possibility is adjusting the protective agent to match the specific protein's characteristics to influence its properties. In a recent study, we developed a flow cytometry-based method to quantify the encapsulation of small molecule dyes in colloidal particles made from guanosine derivatives (SHS particles). We aimed to determine if this method could quantify protein encapsulation and track changes and if proteins could be tuned to bind to these particles. Our results showed that FITC-labeled proteins had apparent association constants in the micromolar range, with hydrophobicity as the dominant factor enhancing the affinities. Confocal laser scanning microscopy imaging supported these results and provided additional information about protein distribution within the particles. We also tested the feasibility of tuning avidin affinity (AVI) for SHS particles with a biotin ligand. We found that increasing the amount of biotin initially enhanced AVI binding, but then reached saturation, which we hypothesize results from non-covalent cross-linking caused by strong biotin/AVI interactions. CLSM images showed that the linker also impacted AVI distribution within the particles. Our strategy provides an advantage over other methods for quantifying protein encapsulation by being suitable for high-throughput analysis with high reproducibility. We anticipate that future efforts of using lower affinity ligands would result in better strategies for modulating protein affinity for drug-delivery applications.
SOCIAL OPTIMISM AS AN INTENTION IN WOMEN'S AUTOBIOGRAPHICAL MEMORY OF THE AGE OF KHRUSHCHEV'S «THAW»: THE PRACTICES OF SELF-ANALYSIS OF ACADEMICIAN P.YA. KOCCHINA
Authors: Белова А.В.
Published: September 2023

Статья посвящена концепту социального оптимизма как ведущей интенции в женской автобиографической памяти эпохи хрущевской «оттепели». На основе исследования опубликованных мемуаров третьей женщины-академика в СССР П.Я. Кочиной выявляются черты социального оптимизма в самоанализе повседневной жизни и мировоззренческих установок, анализируются некоторые вехи профессионального и общественного пути учёной, выясняется сопряженность индивидуальных и коллективных ценностных ориентаций. В заключении делается вывод о том, что позитивные жизненные установки, которые содержали колоссальный преобразовательный потенциал, характеризовали и ее собственное мировоззрение, и своеобразный «женский голос» эпохи, озвучивший коллективную автобиографическую память женщин и воплотивший опыты их повседневности, устремленной к созданию социального проекта «лучшего будущего».

The article is devoted to the concept of social optimism as the leading intention in women's autobiographical memory of the era of the Khrushchev “thaw”. On the basis of a study of the published memoirs of the third womаn-academician in the USSR, P. Ya. Kochina, the author reconstructs the elements of reflection of everyday life and worldview, analyzes some milestones of the professional and social path of the scientist, finds out the conjugation of individual and collective value orientations. In conclusion the author claims that positive life attitudes, which contained a colossal transformative potential, characterized both her own worldview and the peculiar “women's voice” of the era, which voiced the collective autobiographical memory of women and embodied the experiences of their everyday life, striving to create a social project of “a better future”.
THE RUSSIAN ORTHODOX CHURCH AND CLERGY DURING THE CIVIL WAR
Authors: Леонтьева Т.Г.
Published: September 2023

В статье представлен обзор событий 1918–1922 гг., которые характеризуют положение Русской православной церкви (РПЦ), и стратегии выживания православного духовенства в условиях Гражданской войны. В силу территориального распада империи РПЦ оказалась на грани потери канонического иерархического управления. Как взаимодействовали советская власть и православная церковь, какие перемены произошли внутри этого некогда «идеологического» института на территории «белых», как влиял на события «православный мир», разделившийся на «красных» и «белых» – эти вопросы освещаются в данной статье. Процессы самоопределения в «православном мире» анализируются на основе широкого круга источников, которые убеждают, что природа «расслоения» духовенства, мировоззренческие трансформации православной паствы таилась не только в от-ношении к «красным» или «белым», но и определялась отношением к каноническим основам православия, поисками «новой религиозности», вероисповедной политикой советской власти.

The article presents an overview of the events of 1918-1922, which charac-terize the state of the Russian Orthodox Church (ROC) and the survival strategy of the Orthodox clergy in the conditions of Civil War. Due to the territorial disintegration of the empire, the ROC was on the verge of losing canonical hierarchical governance. How the Soviet government and the Orthodox Church interacted, what changes took place inside this once «ideological» institution on the territory of the «whites», how the «Orthodox world», divided into «reds» and «whites» influenced the events - these issues are covered in this article. The processes of self-determination in the «Orthodox world» are analyzed on the basis of a wide range of sources that convince that the nature of the «stratification» of the clergy, the ideological transformations of the Orthodox flock were hidden not only in relation to the «red» or «white», but also determined by the attitude to the canonical foundations of Orthodoxy, the search for «new religiosity», religious the policy of the Soviet government.