bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical characteristics and 6-month follow-up of adults with and without alcohol use disorder who self-harm
Authors: Olsson Petter , Wiktorsson Stefan , Strömsten Lotta M. J. , Salander Renberg Ellinor , Runeson Bo , Waern Margda
Published: August 2024

Background

Alcohol use disorder (AUD) is associated with suicidal behavior, but prospective clinical studies are lacking.

Aim

To compare clinical characteristics and 6-month outcomes in persons with and without AUD who self-harm.

Methods

804 adults (mean age 33, age range 18-95, 541 women and 263 men, 666 with suicide attempts and 138 with non-suicidal self-injuries at index) at three Swedish university hospitals took part in a research interview that included the Mini International Neuropsychiatric Interview (MINI). Subsequent non-fatal suicidal behavior within six months was identified by record review; suicides were identified by national register.

Results

At index, 39% of the men and 29% of the women had AUD. Over two thirds of these cases (69%) were identified by the MINI, but not by clinical AUD diagnosis. While trait impulsivity was more common among persons with AUD than those without (56% vs 36%, P
adj = <.001), impulsivity in connection with the index attempt was noted in half of the participants in each group (48% vs 52%, P adj = 1). Subsequent suicidal behavior (fatal/non-fatal) occurred in 67 persons with AUD (26%) and in 98 without AUD (18%), a 60% higher risk among persons with AUD (OR = 1.60, 95% [CI 1.13-2.28], P = .009). Four persons with AUD (2%) and six without (1%) died by suicide within 6 months.

Conclusion

Almost a third of patients presenting at psychiatric emergency settings after self-harm fulfilled criteria for AUD, but clinicians often missed this diagnosis. Risk for subsequent suicidal behavior was elevated in patients with AUD. Educational interventions to improve recognition of alcohol use disorder may aid clinicians in the assessment and management of patients who present with self-harm.
Public health impacts of air pollution from the spatiotemporal heterogeneity perspective: 31 provinces and municipalities in China from 2013 to 2020
Authors: Ye Yizhong , Tao Qunshan , Wei Hua
Published: August 2024

Air pollution has long been a significant environmental health issue. Previous studies have employed diverse methodologies to investigate the impacts of air pollution on public health, yet few have thoroughly examined its spatiotemporal heterogeneity. Based on this, this study investigated the spatiotemporal heterogeneity of the impacts of air pollution on public health in 31 provinces in China from 2013 to 2020 based on the theoretical framework of multifactorial health decision-making and combined with the spatial durbin model and the geographically and temporally weighted regression model. The findings indicate that: (1) Air pollution and public health as measured by the incidence of respiratory diseases (IRD) in China exhibit significant spatial positive correlation and local spatial aggregation. (2) Air pollution demonstrates noteworthy spatial spillover effects. After controlling for economic development and living environment factors, including disposable income, population density, and urbanization rate, the direct and indirect spatial impacts of air pollution on IRD are measured at 3.552 and 2.848, correspondingly. (3) China’s IRD is primarily influenced by various factors such as air pollution, economic development, living conditions, and healthcare, and the degree of its influence demonstrates an uneven spatiotemporal distribution trend. The findings of this study hold considerable practical significance for mitigating air pollution and safeguarding public health.
Understanding psychotic-like experiences in children in the context of dimensions of psychological problems
Authors: Jeong Hee Jung , Lahey Benjamin B. , Reimann Gabrielle E. , Durham E. Leighton , Archer Camille , Moore Tyler M. , Shah Krisha , Kaczkurkin Antonia N.
Published: August 2024

Introduction

Although psychotic behaviors can be difficult to assess in children, early identification of children at high risk for the emergence of psychotic symptoms may facilitate the prevention of related disorders. Psychotic-like experiences (PLEs), or subthreshold thought and perceptual disturbances, could be early manifestations of psychosis that may predict a future diagnosis of a psychosis-related disorder or nonspecific correlates of a wide range of psychological problems. Additional research is needed regarding how PLEs map onto dimensions of psychopathology in children.

Methods

In the present study, we examined the association between PLEs and general and specific dimensions of psychological problems in a sample of 10,692 children from the Adolescent Brain Cognitive Development Study (ABCD Study).

Results

The results of this study showed that self-reported PLEs were associated with a general psychopathology factor and an ADHD factor, which were defined in hierarchical models of parent-rated psychological problems.

Discussion

These findings suggest that PLEs are broadly associated with a wide range of psychological problems through the general psychopathology factor even before psychotic disorders typically manifest. This study supports the need for longitudinal analyses of future waves of the ABCD Study to determine if PLEs can detect children at high risk for serious psychological problems in adulthood.
Facing Social Fears: Conquering Social Anxiety in the Real World and With the Help of Virtual Reality
Authors: Timmerman Nicky , Wolfert Jordy , Wong Alex H. K. , Wening Manon , Wieser Matthias J. , Harrewijn Anita , Franzen Minita
Published: August 2024

Everyone feels anxious at some point in their lives. Feeling anxious can be very helpful when you are in danger, as it reminds you to avoid harmful situations. However, some people have such strong anxiety that it becomes an anxiety disorder. Such strong anxiety can cause problems and distress in people’s daily lives, and they may even start to avoid feared situations. There is a specific type of anxiety disorder in which people feel very anxious when they are around others. This is called social anxiety disorder. Fortunately, there are effective ways to help people with social anxiety, one of which is called exposure therapy. This type of therapy helps people to face their fears and learn to control their anxiety. Exposure therapy can be done in the real world or through virtual reality. In this article, we will explain how social anxiety can be tackled with exposure therapy and how virtual reality can help.
Constraining the minimally extended varying speed of light model using time dilations
Authors: Lee Seokcheon
Published: August 2024

The Robertson–Walker (RW) metric, derived from the cosmological principle and Weyl’s postulate, characterizes the ΛCDM cosmological model. Traditionally, in this framework, the assumption of a constant speed of light leads to specific cosmological time dilation (TD). However, because the Robertson–Walker metric lacks a way to define time dilation, the speed of light, like wavelength and temperature, may vary with cosmic time. The minimally extended varying speed of light (meVSL) model fits standard cosmological observations while considering the evolution of physical constants. One model-independent test for the meVSL model is cosmological time dilation. However, current data cannot distinguish between the meVSL model and the standard model.
Development of Vertical Vibration Model for Micro-Tiller by Smoothed Particle Hydrodynamics Method
Authors: Liu Xiaochan , Hao Wenchang , Chen Yong , Hao Qingle , Zhang Xiuli , Sun Zhipeng
Published: August 2024

A micro-tiller vibrates severely during the rotary tillage process, which may cause operators to develop white finger disease. However, for most vibration models, the acting force between the soil and the rotary cutter roll was simplified to only a constant or sine curve, which may not describe the whole dynamic. Rotary tillage processes have been simulated based on the smoothed particle hydrodynamics method in this paper. The acting forces of the soil on the cutter roll have been obtained with the simulation model. Four different working conditions were simulated. The average error between the calculated forces and the simulated mean forces is 10.96%, which proves the SPH model. By introducing simulated acting forces into the vibration model, a new vibration model of the micro-tiller, which includes the soil–blade interaction, has been constructed. Time and frequency characteristics were simulated with the new vibration model. The errors between the simulated and tested RMS values are 4.28%, 5.03%, and 6.35% for the engine, cutter roll, and right handle, respectively. Two domain-dominant frequencies were found with the vibration model, namely 44.7 Hz and 257.0 Hz. It is helpful to reveal the whole dynamic map of micro-tillers.
Molecular Regulation Mechanisms of Ripening, Senescence and Stress Resistance in Fruits and Vegetables
Authors: Huang Hua
Published: August 2024

Fruits and vegetables are two key daily sources of food for human beings [...]
Evaluation of Stress Scores of Healthy Adult Cats during Barometric Whole-Body Plethysmography and Its Correlation with Measurement Parameters
Authors: Benz Petra , Zablotski Yury , Schulz Bianka
Published: August 2024

Barometric whole-body plethysmography (BWBP) is considered to be a particularly gentle method of assessing lung function in cats. However, there have been no studies to date investigating the stress experienced by cats during measurements. The prospective study included 48 healthy adult cats. Each cat was measured in the plethysmographic chamber for a total of 30 min and stress levels were determined every 10 min using a stress ethogram. At the beginning of measurements, 75% of cats were assessed as tense. Over the three time periods, a significant (p < 0.001) reduction in the total stress score was observed. In addition, all measurement parameters correlated significantly with the stress score, with the exception of enhanced pause and tidal volume. It can therefore be assumed that cats will initially experience stress during examination in the plethysmographic chamber, but stress will decrease significantly over time. As the stress level correlates with many measurement parameters, this should be taken into account when interpreting the results.
Chondroitin Sulfate Ameliorates Hypertension in Male Offspring Rat Born to Mothers Fed an Adenine Diet
Authors: Tain You-Lin , Hou Chih-Yao , Chang-Chien Guo-Ping , Lin Shu-Fen , Hsu Chien-Ning
Published: August 2024

Pregnant women with chronic kidney disease (CKD) face increased risks of adverse outcomes in their adult offspring. Offspring rats born to dams fed an adenine diet develop hypertension, coinciding with dysregulated hydrogen sulfide (H2S) and nitric oxide (NO) pathways, as well as alterations in gut microbiota. Chondroitin sulfate (CS) is a multifunctional food known for its diverse bioactivities. As a sulfate prebiotic, CS has shown therapeutic potential in various diseases. Here, we investigated the protective effects of maternal CS supplementation against hypertension in offspring induced by an adenine diet. Mother rats were administered regular chow, 0.5% adenine, 3% CS, or a combination throughout gestation and lactation. Maternal CS supplementation effectively protected offspring from hypertension induced by the adenine diet. These beneficial effects of CS were connected with increased renal mRNA and protein levels of 3-mercaptopyruvate sulfurtransferase, an enzyme involved in H2S production. Furthermore, maternal CS treatment significantly enhanced alpha diversity and altered beta diversity of gut microbiota in adult offspring. Specifically, perinatal CS treatment promoted the abundance of beneficial microbes such as Roseburia hominis and Ruminococcus gauvreauii. In conclusion, perinatal CS treatment mitigates offspring hypertension associated with maternal adenine diet, suggesting that early administration of sulfate prebiotics may hold preventive potential. These findings warrant further translational research to explore their clinical implications.
Role of Extracellular Vesicles in the Progression of Brain Tumors
Authors: Schiera Gabriella , Di Liegro Carlo Maria , Vento Francesco , Di Liegro Italia
Published: August 2024

Brain tumors, and, in particular, glioblastoma (GBM), are among the most aggressive forms of cancer. In spite of the advancement in the available therapies, both diagnosis and treatments are still unable to ensure pathology-free survival of the GBM patients for more than 12–15 months. At the basis of the still poor ability to cope with brain tumors, we can consider: (i) intra-tumor heterogeneity; (ii) heterogeneity of the tumor properties when we compare different patients; (iii) the blood–brain barrier (BBB), which makes difficult both isolation of tumor-specific biomarkers and delivering of therapeutic drugs to the brain. Recently, it is becoming increasingly clear that cancer cells release large amounts of extracellular vesicles (EVs) that transport metabolites, proteins, different classes of RNAs, DNA, and lipids. These structures are involved in the pathological process and characterize any particular form of cancer. Moreover, EVs are able to cross the BBB in both directions. Starting from these observations, researchers are now evaluating the possibility to use EVs purified from organic fluids (first of all, blood and saliva), in order to obtain, through non-invasive methods (liquid biopsy), tumor biomarkers, and, perhaps, also for obtaining nanocarriers for the targeted delivering of drugs.
Investigating Development and Defense Systems in Early Reproductive Stages of Male and Female Gonads in Black Scorpionfish Scorpaena porcus (Linnaeus, 1758)
Authors: Alesci Alessio , Marino Sebastian , D’Iglio Claudio , Morgante Silvana , Miller Anthea , Rigano Gabriele , Ferri Josipa , Fernandes Jorge M. O. , Capillo Gioele
Published: August 2024

One of the most crucial biological indicators in tracking long-term variations in the reproductive cycle is sexual development. Scorpaena porcus (Linnaeus, 1758), commonly known as the black scorpionfish, is a small teleost from the family Scorpaenidae. Much is known about its ecology, but data on its reproductive and defense systems are still lacking. Antimicrobial peptides (AMPs), such as piscidins, are integral components of the innate immune system in fish. These peptides exhibit a wide range of activity against bacteria, fungi, viruses, and protozoa and act as the first line of host defense. This study aims to investigate the primary sexual development stages in male and female gonads of black scorpionfish, providing additional knowledge on the reproductive biology of this teleost while evaluating concomitant changes in the expression of a Piscidin-1 antimicrobial peptide. The results show a histological, morpho-structural change from the immature stage to the developing virgin stage. Immunohistochemical analyses show that germinal and somatic cells are strongly reactive to Piscidin-1 in both gonads at an early ontogeny stage. These data suggest that Piscidin-1 may play a key role in the local defense system of scorpionfish gonads at this delicate stage, which is critical for the continuation and maintenance of the species. The present findings are potentially useful for a better understanding of the reproductive cycle of this fish, improving our knowledge of the interaction between the immune system and reproduction.
The Gut Microbiome as a Catalyst and Emerging Therapeutic Target for Parkinson’s Disease: A Comprehensive Update
Authors: Kerstens Rebecca , Joyce Paul
Published: August 2024

Parkinson’s Disease is the second most prevalent neurological disorder globally, and its cause is still largely unknown. Likewise, there is no cure, and existing treatments do little more than subdue symptoms before becoming ineffective. It is increasingly important to understand the factors contributing to Parkinson’s Disease aetiology so that new and more effective pharmacotherapies can be established. In recent years, there has been an emergence of research linking gut dysbiosis to Parkinson’s Disease via the gut–brain axis. Advancements in microbial profiling have led to characterisation of a Parkinson’s-specific microbial signature, where novel treatments that leverage and correct gut dysbiosis are beginning to emerge for the safe and effective treatment of Parkinson’s Disease. Preliminary clinical studies investigating microbiome-targeted therapeutics for Parkinson’s Disease have revealed promising outcomes, and as such, the aim of this review is to provide a timely and comprehensive update of the most recent advances in this field. Faecal microbiota transplantation has emerged as a novel and potential frontrunner for microbial-based therapies due to their efficacy in alleviating Parkinson’s Disease symptomology through modulation of the gut–brain axis. However, more rigorous clinical investigation, along with technological advancements in diagnostic and in vitro testing tools, are critically required to facilitate the widespread clinical translation of microbiome-targeting Parkinson’s Disease therapeutics.
Are Deaf College Students More Sensitive to Unfair Information? Evidence from an ERP Study
Authors: Sun Le , Dong Qi , Du Xue , Wei Dongtao
Published: August 2024

To better understand the individual differences in fairness, we used event-related potentials (ERPs) to explore the fairness characteristics of deaf college students through the ultimatum game task. Behaviorally, the significant main effect of the proposal type was found, which meant both deaf and hearing college students showed a lower acceptance rate for the more unfair proposal. Interestingly, we found a significant interaction between group and proposal type in the early stage (N1). Moreover, in the deaf college group, N1 (induced by moderately and very unfair proposals) was significantly larger than that of fair proposals. However, we found that deaf college students had smaller amplitudes on P2 and P3 than hearing college students. These results suggested that deaf college students might pursue more equity strongly so they are more sensitive to unfair information in the early stage. In a word, we should provide more fair allocations for deaf college students in our harmonious society.
Emergency Department Utilization Due to Challenging Behavior in Children and Adolescents Diagnosed with Autism Spectrum Disorder
Authors: Jeglum Sara R. , Cicero Alexandra , DeBrine Jordan , Livingston Cynthia P.
Published: August 2024

Children and adolescents with autism spectrum disorder (ASD) are at a greater risk of seeking emergency department (ED) services during behavioral crises, such as acute aggression, suicidal or homicidal ideation, self-injury, or other types of challenging behavior (e.g., pica, dangerous behaviors). Research demonstrates children and adolescents with ASD often return to the ED due to challenging behavior, suggesting that gaps in care exist (e.g., follow-up appointments, referrals). However, the current knowledge basis is largely based on data from other countries. Given the unique landscape of healthcare in the United States, it is prudent to elucidate characteristics of children and adolescents with ASD who are seeking emergency care due to challenging behavior, as well as systems-level factors that both contribute to our understanding of challenging behavior and ASD in ED settings. In this study, we focus on frequency and characteristics of children and adolescents with ASD presenting to the ED with challenging behavior over the course of a 6-year period in the Midwest region of the United States. Clinical implications for ED staff are discussed.
Addressing the “Lying Flat” Challenge in China: Incentive Mechanisms for New-Generation Employees through a Moderated Mediation Model
Authors: Zhou Jie , Yang Junqing , Faye Bonoua
Published: August 2024

Given the increasing emphasis on teamwork in contemporary organizations and the growing prominence of younger employees in the workplace, it is crucial to encourage their proactivity in navigating complex internal and external environments. Total rewards are a highly effective means of motivating the new generation of employees; however, there is limited research on whether and how total rewards stimulate team member proactivity. To address this objective, this study utilizes survey data (n = 423) and employs hierarchical regression and bootstrap methods. In essence, this paper aims to construct a moderated mediation model to examine the relationship between total rewards and team member proactivity among Chinese new-generation employees (born after 1990). The results indicate that total rewards significantly enhance the team member proactivity of new-generation employees. Furthermore, calling serves as a significant mediator in this relationship. The perception of corporate social responsibility also plays a crucial role, positively moderating the relationship between total rewards and calling. This, in turn, positively influences team member proactivity through the mediation of calling. Accordingly, this research provides valuable insights for managers aiming to effectively engage the new generation of employees and boost team performance. In essence, our model enriches the understanding of how compensation practices can be leveraged to boost proactivity among the new generation of employees.
Construction Mechanical Characteristics and Monitoring Analysis of the Existing Subway over the Newly Built Long Foundation Pit
Authors: Niu Peng , Zhou Puxin , Jin Chunfu , Shao Yuwei
Published: August 2024

In view of the safety of the construction of the long foundation pit of the new upper span to the existing subway under urban complex environment conditions, combined with the construction of the intersection section of the first line of the existing subway across the north–south Expressway in Shenyang, the mechanical properties during construction were studied by means of numerical simulation and on-site monitoring. The results showed that the general deformation characteristic of the existing metro tunnel was “uplift first, then restrain”. The local deformation characteristic was an unloading rebound in the cross region, and a compression deformation occurs outside the cross region. The index could be controlled in the range of the control value of the existing line protection by adopting the measures consisting of an uplift pile + capping beam balance, reinforcing the surrounding soil, the excavation of the foundation pit in sections, and the comprehensive construction.
Aspects of Modeling Prestressed Concrete Sleepers Subjected to Positive Moment Test at Midspan
Authors: Randi Ricardo P. , Trautwein Leandro M. , dos Santos Antônio C.
Published: August 2024

This paper aims to discuss aspects of modeling prestressed concrete sleepers based on experimental results. Midspan Positive Moment tests were performed on four prestressed sleepers. Using the ATENA 3D software, based on the Finite Element Method, numerical models were simulated through nonlinear analysis to adequately represent the behavior of the sleepers. To evaluate the influence of the crack model, the Young’s modulus, and the fracture energy, a parametric numerical analysis was performed, varying these parameters in stages to achieve a more realistic model. The crack model was evaluated by modifying the “fixed crack model” to a “rotated crack model” while the Young’s modulus and fracture energy were penalized by 0.00%, 5.00%, 10.00%, and 15.00% in relation to the value calculated according to the CEB FIP Model Code (2010). The numerical model with the “rotated crack model” and penalties of 0.00% and 5.00% for the Young’s modulus and fracture energy, respectively, presented a better approximation to the results presented in the experimental tests. Finally, from this calibrated model, an experimental versus numerical comparative analysis was performed, comparing the load versus displacement curves, failure loads, maximum displacements, and crack pattern behavior. In the future, constitutive models of bond slip and expansive reactions will be applied to the calibrated model.
Observation and Management of Juvenile Myelomonocytic Leukemia and Noonan Syndrome-Associated Myeloproliferative Disorder: A Real-World Experience
Authors: Lucas Bryony J. , Connors Jeremy S. , Wang Heping , Conneely Shannon , Cuglievan Branko , Garcia Miriam B. , Rau Rachel E.
Published: August 2024

Juvenile Myelomonocytic Leukemia (JMML) is a rare and clonal hematopoietic disorder of infancy and early childhood with myeloproliferative/myelodysplastic features resulting from germline or somatic mutations in the RAS pathway. Treatment is not uniform, with management varying from observation to stem cell transplant. The aim of our retrospective review is to describe the treatment and outcomes of a cohort of patients with JMML or Noonan Syndrome-associated Myeloproliferative Disorder (NS-MPD) to provide management guidance for this rare and heterogeneous disease. We report on 22 patients with JMML or NS-MPD managed at three institutions in the Texas Medical Center. Of patients with known genetic mutations and cytogenetics, 6 harbored germline mutations, 12 had somatic mutations, and 9 showed cytogenetic abnormalities. Overall, 14/22 patients are alive. Spontaneous clinical remission occurred in one patient with somatic NRAS mutation, as well as two with germline PTPN11 mutations with NS-MPD, and two others with germline PTPN11 mutations and NS-MPD remain under surveillance. Patients with NS-MPD were excluded from treatment analysis as none required chemotherapeutic intervention. All patients (5/5) treated with 5-azacitidine alone and one of the four treated with 6-mercaptopurine monotherapy had a reduction in mutant variant allele frequency. Transformation to acute myeloid leukemia was seen in two patients who both died. Among patients who received transplants, 7/13 are alive, and relapse post-transplant occurred in 3/13 with a median time to relapse of 3.55 months. This report provides insight into therapy responses and long-term outcomes across different genetic subsets of JMML and lends insight into the expected time to spontaneous resolution in patients with NS-MPD with germline PTPN11 mutations.
Electrochemical Determination of Tryptophan Based on Gly@CDs Clusters Modified Glassy Carbon Electrode
Authors: Bortolami Martina , Di Matteo Paola , Mastrorilli Piero , Petrucci Rita , Trani Alessandro , Vetica Fabrizio , Feroci Marta , Curulli Antonella
Published: August 2024

A simple sensor for the quantitation of tryptophan (Trp) has been developed using a glassy carbon electrode (GCE) modified with electro-synthesized carbon dots functionalized with glycine (Gly@CDs). The surface functionalization with an amino acid led to the formation of large clusters of nanostructures. To our knowledge, this is the first study in which a Gly@CDs clusters modified GCE is used for the analysis of Trp. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) are the techniques used to study Trp electrochemical behavior in an alkaline solution using such an electrode. A linear concentration range was found for Trp from 5 × 10−6 to 5 × 10−3 mol L−1 with a detection limit (LOD) of 5 × 10−6 mol L−1. The reproducibility and repeatability data were satisfactory in terms of RSD%. Moreover, the stability during the time of the modified electrode was considered, evidencing interesting results. The described sensor was used for the determination of Trp in herbal tea and a dietary supplement, and the results were compared with those obtained with HPLC-ESI-MS in the Selected Ion Recording (SIR) mode as an independent method. The electrochemical sensor presents significant advantages in terms of low cost, portability, ease of handling and not requiring skilled personnel.
Natural Tannin Layers for the Corrosion Protection of Steel in Contact with Water-Based Media
Authors: Sesia Rossella , Spriano Silvia , Sangermano Marco , Calovi Massimo , Rossi Stefano , Ferraris Sara
Published: August 2024

Numerous strategies have been developed for the corrosion protection of steel; however, most of them have a significant environmental impact and employ toxic compounds. Tannins are a green and promising solution for sustainable corrosion protection strategies. In this context, this work was focused on natural (condensed and hydrolysable) tannin layers as a possible corrosion protection strategy for carbon steel. The impact of the tannins’ dissolution medium (ultrapure water or Phosphate-Buffered Saline), surface pre-treatment (acid pickling or plasma), and deposition technology (dipping or spin coating) on layer homogeneity and adhesion has been evaluated. The effects of these parameters on coating formation, homogeneity, and adhesion have been investigated by means of visual inspections, swabbing, Fourier Transformed Infrared spectroscopy (FTIR), Scanning Electron Microscopy equipped with Energy Dispersive Spectroscopy (SEM-EDS) and tape adhesion tests. Preliminary electrochemical corrosion tests have been performed on the most promising material (carbon steel acid pickled and coated with a hydrolysable tannin solved in water by spin coating) to estimate the protective ability of the developed layers and highlight the main criticisms to be overcome.
Enhanced Analysis of Ice Accretion on Rotating Blades of Horizontal-Axis Wind Turbines Using Advanced 3D Scanning Technology
Authors: Lei Zhen , Dong Yuxiao , Wang Qinghui , Li Hailin , Han Yexue , Feng Fang
Published: August 2024

This study investigated the meteorological conditions leading to ice formation on wind turbines in a coastal mountainous area. An enhanced ice formation similarity criterion was developed for the experimental design, utilizing a scaled-down model of a 1.5 MW horizontal-axis wind turbine in icing wind tunnel tests. Three-dimensional ice shapes on the rotating blades were obtained and scanned using advanced 3D laser measurement technology. Post-processing of the scanned data facilitated the construction of solid models of the ice-covered blades. This study analyzed the maximum ice thickness, ice-covered area, and dimensionless parameters such as the maximum dimensionless ice thickness and dimensionless ice-covered area along the blade. Under the experimental conditions, the maximum ice thickness reached 0.5102 m, and the ice-covered area extended up to 0.5549 m2. The dimensionless maximum ice thickness and dimensionless ice-covered area consistently increased along the blade direction. Our analysis of 3D ice shape characteristics and the ice volume under different test conditions demonstrated that wind speed and the liquid water content (LWC) are critical factors affecting ice formation on blade surfaces. For a constant tip speed ratio, higher wind speeds and a greater LWC resulted in increased ice volumes on the blade surfaces. Specifically, increasing the wind speed can augment the ice volume by up to 57.2%, while increasing the LWC can enhance the ice volume by up to 149.2% under the experimental conditions selected in this study.
Doping and Superhydrophobic Modification for Improving Marine Antifouling Performance of Alkali-Based Geopolymer Coating
Authors: Sun Mingyang , Qin Yao , Tan Jianli , Liu Jiazheng , Li Jing , Cui Xuemin
Published: August 2024

Although pure alkali-activated materials (AAMs) only depend on high alkalinity to resist biological pollution, the effects of which are inadequate, it is essential to add cuprous oxide to reinforce the antifouling effect. In this paper, triethoxycaprylylsilane (TTOS) was used as a superhydrophobic modifier that was copolymerized with the exposed hydroxyl groups on the alkali-based geopolymers coating and then generated micro/nanostructures. Therefore, superhydrophobic geopolymer coating can achieve long-lasting controlled release of Cu2+ by controlling the inflow and outflow of water to achieve the aim of extending the antibiofouling life of coating when cuprous oxide is added to alkali-based geopolymer.
Atomristor Mott Theory of Sn Adatom Adlayer on a Si Surface
Authors: Craco Luis , Chagas Edson F. , Carara Sabrina S. , Freelon Byron
Published: August 2024

We use a combination of density functional theory (DFT) and dynamical mean field theory (DMFT) to unveil orbital field-induced electronic structure reconstruction of the atomic Sn layer deposited onto a Si(111) surface (Sn/Si(111)−3×3R30∘), also referred to as α-Sn. Our DFT + DMFT results indicate that α-Sn is an ideal testing ground to explore electric field-driven orbital selectivity and Mott memory behavior, all arising from the close proximity of α-Sn to metal insulator transitions. We discuss the relevance of orbital phase changes for α-Sn in the context of the current–voltage (I−V) characteristic for future silicon-based metal semiconductor atomristors.
Unexpected Formation of 6-(1H-Benzo[d]imidazol-2-yl)-1-phenyl-hexan-1-one and Its Structure in Solution and Solid State Analyzed in the Context of Tautomerism
Authors: Nazarski Ryszard B. , Domagała Małgorzata
Published: August 2024

The structure of the title compound (4d), unexpectedly obtained in the reaction between o-phenylenediamine and 2-benzoylcyclohexanone instead of the target 3H-benzo[b][1,4]diazepine derivative 3d, was determined spectroscopically in solution and by a single-crystal X-ray diffraction (XRD) study. It involves two enantiomeric rotamers, called forms D and U, of which the structure was elucidated based on NMR spectra measured and predicted in DFT-GIAO calculations. An averaging of δCs for all tautomeric positions in the benzimidazole part of the 4d hydrate studied in wet (probably slightly acidic) CDCl3 unambiguously indicates tautomeric exchange in its imidazole unit. An XRD analysis of this material confirms the existence of only one tautomer in the solid phase. The non-covalent interactions forming between molecules of water and benzimidazole derivative are shorter than the sum of van der Waals radii and create an infinite-chain hydrogen bond motif along the b-axis. A possible mechanism for the observed cyclocondensation is also proposed.
Genetic Variation among Rare Florida Endemic Hymenocallis henryae Populations and the Implication for Conservation and Management
Authors: Vogel Maria Therese , Moore Richard C. , Negrón-Ortiz Vivian
Published: August 2024

Hymenocallis henryae is a rare, charismatic spider lily endemic to the Florida panhandle. Currently under review to determine if listing under the Endangered Species Act is warranted, this species has undescribed genetic diversity, information crucial to the listing process. We conducted field observations of 21 historic populations across the species’ geographical range and performed genomic analyses of 279 individuals from 19 extant populations. Most populations had fewer than 40 individuals, while populations with >100 individuals were found exclusively on managed lands. Genetic diversity was uniformly low within populations (HE: 0.074–0.093), with low to moderate inbreeding coefficients (FIS: 0.068–0.431). Genetic differentiation was relatively low among most populations (FST: 0–0.098), although there was statistical support for isolation by distance. In addition, we found high genetic similarity and lack of population structure across the species range. Clonal propagation through fused bulbs is a common reproductive strategy. We confirmed current threats (habitat change, residential development, fire suppression) and identified several coastal populations threatened by sea level rise. It is recommended to continue with in situ protection and management as well as the establishment of ex situ living collections to preserve populations most at risk of extirpation from habitat loss and degradation.
Unveiling TIMPs: A Systematic Review of Their Role as Biomarkers in Atherosclerosis and Coronary Artery Disease
Authors: Aminuddin Amilia , Samah Nazirah , Vijakumaran Ubashini , Che Roos Nur Aishah , Nor Faridah Mohd , Wan Razali Wan Mohammad Hafiz , Mohamad Shawal Faizal , Cong Beh Boon , Hamzah Faizal Amri , Hamid Adila A. , Ugusman Azizah
Published: August 2024

Coronary artery disease (CAD) is the leading cause of death globally and is a heart condition involving insufficient blood supply to the heart muscle due to atherosclerotic plaque formation. Atherosclerosis is a chronic disease in which plaques, made up of fat, cholesterol, calcium, and other substances, build up on the inner walls of arteries. Recently, there has been growing interest in finding reliable biomarkers to understand the pathogenesis and progression of atherosclerosis. Tissue Inhibitors of Metalloproteinases (TIMPs) have emerged as potential candidates for monitoring atherosclerotic development. TIMPs are a family of endogenous proteins that regulate matrix metalloproteinases (MMPs), enzymes involved in remodeling the extracellular matrix. A systematic search using Prisma guidelines was conducted and eleven studies were selected from four different databases: Web of Science (WOS), Scopus, Ovid, and PubMed. The Newcastle–Ottawa Scale (NOS) score was used to assess the risk of bias for each study. A meta-analysis was performed, and the hazard ratio (HR) and its 95% confidence interval (CI) were determined. Among the eleven studies, six reported a positive association between higher levels of TIMPs and an increased risk of atherosclerosis. Conversely, four studies support low TIMPs with high CAD risk and one study showed no significant association between TIMP-2 G-418C polymorphism and CAD. This divergence in findings underscores the complexity of the relationship between TIMPs, atherosclerosis, and CAD. In addition, a meta-analysis from two studies yielded a HR (95% CI) of 1.42 (1.16–1.74; p < 0.001; I2 = 0%) for TIMP-2 in predicting major adverse cardiovascular events (MACEs). In conclusion, the existing evidence supports the notion that TIMPs can serve as biomarkers for predicting the severity of atherosclerosis, myocardial damage, and future MACEs among CAD patients. However, further exploration is warranted through larger-scale human studies, coupled with in vitro and in vivo investigations.
Exploring the Acceptability of HIV Testing in the UK Dental Setting: A Qualitative Study
Authors: Yazdi-Doughty Janine , Santella Anthony J. , Porter Stephen , Watt Richard G. , Burns Fiona
Published: August 2024

HIV point of care testing (POCT) is a common approach to expanding testing into non-specialised settings. Dental services have untapped potential to screen for health conditions including HIV. However, the perspectives of UK dental patients, dental professionals, and people with HIV are unknown. Ten focus groups were undertaken with dental patients, professionals, and people with HIV. The Framework method was used to analyse the qualitative data. Six themes were generated from the focus group data. The themes explored perceptions of HIV, the purpose, appropriateness, and acceptability of HIV testing in dental settings, and new processes that would need to be established in order to successfully implement point of care HIV testing in UK dental settings. Training needs were identified including communication skills and updates to current knowledge about HIV. HIV testing in dental settings is generally acceptable to dental patients, dental professionals, and PWH. However, of concern were logistical challenges and the risk of patients surprised at being offered an HIV test during a visit to the dentist. Nonetheless, the public health benefits of the intervention were well understood, i.e., early detection of HIV and initiation of treatment to improve health outcomes. Dental teams were able to generate novel solutions that could help to overcome contextual and logistical challenges to implementing HIV testing in dental settings.
Pseudospectral-Based Rapid Trajectory Planning and Feedforward Linearization Guidance
Authors: Mu Lingxia , Cao Shaowei , Wang Ban , Zhang Youmin , Feng Nan , Li Xiao
Published: August 2024

A trajectory-based guidance strategy is proposed for the three-dimensional terminal return task of an uncrewed space vehicle (USV). The overall guidance scheme consists of reference trajectory planning and robust trajectory tracking modules. The trajectory planning algorithm involves determining the motion of the USV to achieve a prescribed target under multiple constraints. The altitude-domain-based USV model is firstly proven to be differentially flat utilizing the dynamic pressure and position of the USV as flat outputs. The original trajectory planning problem is reformulated in a lower-dimensional flat output space. The discretization of the planning problem is then achieved using the pseudospectral method, based on which an initial guess technique is designed in order to accelerate the solving speed of the planning algorithm. Subsequently, a feedforward linearization-based trajectory tracking guidance law is designed using the differential flatness property of the altitude-domain model. Simulation results in different scenarios show that the proposed guidance strategy provides a satisfactory guidance solution.
Impact of Communication Link Overload on Power Flow and Data Transmission in Cyber–Physical Power Systems
Authors: Liu Xinyu , Li Yan , Xu Tianqi
Published: August 2024

The volume of flow demand in cyber-physical power systems (CPPSs) fluctuates unevenly across coupled networks and is susceptible to congestion or overload due to consumers’ energy demand or extreme disasters. Therefore, considering the elasticity of real networks, communication links with excessive information flow do not immediately disconnect but have a certain degree of redundancy. This paper proposes a dynamic cascading failure iterating model based on the distribution of information flow overload in a communication network and power flow betweenness in the physical power grid. First, a nonlinear load capacity model of a communication network with overload and weighted edges is introduced, fully considering the three link states: normal, failure, and overload. Then, flow betweenness substitutes for branch flows in the physical power network, and power flow on failed lines is redistributed using the load capacity model, simplifying the calculations. Third, under the influence of coupling relations, a comprehensive model based on improved percolation theory is constructed, with attack strategies formulated to more accurately assess the coupled networks. Simulations on the IEEE-39 bus system demonstrate that considering the overload capacity of communication links on a small scale enhances the robustness of coupled networks. Furthermore, deliberate link attacks cause more rapid and extensive damage compared to random attacks.
Module Tester for Positron Emission Tomography and Particle Physics
Authors: Baranyai David , Oniga Stefan , Gyongyosi Balazs , Ujvari Balazs , Mohamed Attia
Published: August 2024

The combination of high-density, high-time-resolution inorganic scintillation crystals such as Lutetium Yttrium Oxyorthosilicate (LYSO), Yttrium Orthosilicate (YSO) and Bismuth Germanate (BGO) with Silicon Photomultiplier (SiPM) sensors is widely employed in medical imaging, particularly in Positron Emission Tomography (PET), as well as in modern particle physics detectors for precisely timing sub-detectors and calorimeters. During the assembly of each module, following individual component testing, the crystals and SiPMs are bonded together using optical glue and enclosed in a light-tight, temperature-controlled cooling box. After integration with the readout electronics, the bonding is initially tested. The final readout electronics typically comprise Application-Specific Integrated Circuits (ASICs) or low-power Analog-to-Digital Converters (ADCs) and amplifiers, designed not to heat up the temperature-sensitive SiPM sensors. However, these setups are not optimal for testing the optical bonding. Specific setups were developed to test the LYSO + SiPM modules that are already bonded but not enclosed in a box. Through large data collection, small deviations in bonding can be detected if the SiPMs and LYSOs have been thoroughly tested before our measurement. The Monte Carlo simulations we used to study how parameters—which are difficult to measure in the laboratory (LYSO absorption length, refractive index of the coating)—affect the final result. Our setups for particle physics and PET applications are already in use by research institutes and industrial partners.
Simulation of Vacuum Distillation Unit in Oil Refinery: Operational Strategies for Optimal Yield Efficiency
Authors: Atta Muhammad Shahrukh , Khan Haris , Ali Muhammad , Tariq Rasikh , Yasir Ahmed Usman , Iqbal Muhammad Mubashir , Din Sullah Ud , Krzywanski Jaroslaw
Published: August 2024

Oil refineries play a crucial role in meeting global energy demands, and optimizing the efficiency of critical processes is vital for economic feasibility and environmental sustainability. Simulation is an essential tool for the optimization of valuable products. This work presents the rigorous simulation of a vacuum distillation unit (VDU) based on actual data from the vacuum distillation processes using Aspen HYSYS V10. The Peng–Robinson fluid package is used in this simulation, and an input assay with a standard density of 29 API_60 (879.8 kg/m3) is employed. True boiling point (TBP) assay data are the type that is being used. Methane, ethane, propane, i-Butane, n-Butane, i-Pentane, and n-Pentane are the components listed in the simulation. The research determines that achieving a yield capacity of 685 tons/h requires thirty stages in the atmospheric distillation unit and twelve stages in the vacuum distillation unit while operating at 420 °C temperature and 9 kPa pressure. Adjustments in the flash section temperature (FST) and steam flow rate (SFR) are proposed to enhance operational efficiency. Increasing the FST from 370 °C to 400 °C and adjusting SFR from 10 tons/h to 26 tons/h increases the Light Vacuum Gas Oil (LVGO) yield by 7.2% while elevating the FST from 400 °C to 430 °C and adjusting SFR from 10 tons/h to 26 tons/h enhances the High Vacuum Gas Oil (HVGO) yield by 7.4%. These optimization strategies offer a practical and effective approach for refineries to improve the economic benefits of vacuum distillation units. The implications of this research can act as a computational thinking exercise for higher education students considering the case study where only through changing the operational strategies can the yield be enhanced by 10.81% in the vacuum distillation unit of the oil refinery.
Review of Proton Exchange Membrane Fuel Cell-Powered Systems for Stationary Applications Using Renewable Energy Sources
Authors: Miri Motalleb , Tolj Ivan , Barbir Frano
Published: August 2024

The telecommunication industry relies heavily on a reliable and continuous power supply. Traditional power sources like diesel generators have long been the backbone of telecom infrastructure. However, the growing demand for sustainable and eco-friendly solutions has spurred interest in renewable energy sources. Proton exchange membrane (PEM) fuel cell-based systems, integrated with solar and wind energy, offer a promising alternative. This review explores the potential of these hybrid systems in stationary telecom applications, providing a comprehensive overview of their architecture, energy management, and storage solutions. As the demand for telecommunication services grows, so does the need for a reliable power supply. Diesel generators are linked with high operational costs, noise pollution, and significant greenhouse gas emissions, prompting a search for more sustainable alternatives. This review analyzes the current state of PEM fuel cell systems in telecom applications, examines the architecture of microgrids incorporating renewable energy sources, and discusses optimization methods, challenges, and future directions for energy storage systems. Critical findings and recommendations are presented, highlighting objectives and constraints for future developments. Leveraging these technologies can help the telecom industry reduce fossil fuel reliance, lower operational costs, minimize environmental impact, and increase system reliability.