bluuebunny/crossref_metadata_2025 huggingface dataset:
4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease
Authors: Komatović Katarina , Matošević Ana , Terzić-Jovanović Nataša , Žunec Suzana , Šegan Sandra , Zlatović Mario , Maraković Nikola , Bosak Anita , Opsenica Dejan M.
Published: June 2022

Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human cholinesterase inhibitors was extended to twenty-two new structurally distinct 4-aminoquinolines bearing an adamantane moiety. Inhibition studies revealed that all of the compounds were very potent inhibitors of AChE and butyrylcholinesterase (BChE), with inhibition constants (Ki) ranging between 0.075 and 25 µM. The tested compounds exhibited a modest selectivity between the two cholinesterases; the most selective for BChE was compound 14, which displayed a 10 times higher preference, while compound 19 was a 5.8 times more potent inhibitor of AChE. Most of the compounds were estimated to be able to cross the blood–brain barrier (BBB) by passive transport. Evaluation of druglikeness singled out fourteen compounds with possible oral route of administration. The tested compounds displayed modest but generally higher antioxidant activity than the structurally similar AD drug tacrine. Compound 19 showed the highest reducing power, comparable to those of standard antioxidants. Considering their simple structure, high inhibition of AChE and BChE, and ability to cross the BBB, 4-aminoquinoline-based adamantanes show promise as structural scaffolds for further design of novel central nervous system drugs. Among them, two compounds stand out: compound 5 as the most potent inhibitor of both cholinesterases with a Ki constant in low nano molar range and the potential to cross the BBB, and compound 8, which met all our requirements, including high cholinesterase inhibition, good oral bioavailability, and antioxidative effect. The QSAR model revealed that AChE and BChE inhibition was mainly influenced by the ring and topological descriptors MCD, Nnum, RP, and RSIpw3, which defined the shape, conformational flexibility, and surface properties of the molecules.
Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair
Authors: Ferreira Patricia Garcia , Ferreira Vitor Francisco , da Silva Fernando de Carvalho , Freitas Cyntia Silva , Pereira Patricia Ribeiro , Paschoalin Vania Margaret Flosi
Published: June 2022

Chitosan displays a dual function, acting as both an active ingredient and/or carrier for pharmaceutical bioactive molecules and metal ions. Its hydroxyl- and amino-reactive groups and acetylation degree can be used to adjust this biopolymer’s physicochemical and pharmacological properties in different forms, including scaffolds, nanoparticles, fibers, sponges, films, and hydrogels, among others. In terms of pharmacological purposes, chitosan association with different polymers and the immobilization or entrapment of bioactive agents are effective strategies to achieve desired biological responses. Chitosan biocompatibility, water entrapment within nanofibrils, antioxidant character, and antimicrobial and anti-inflammatory properties, whether enhanced by other active components or not, ensure skin moisturization, as well as protection against bacteria colonization and oxidative imbalance. Chitosan-based nanomaterials can maintain or reconstruct skin architecture through topical or systemic delivery of hydrophilic or hydrophobic pharmaceuticals at controlled rates to treat skin affections, such as acne, inflammatory manifestations, wounds, or even tumorigenesis, by coating chemotherapy drugs. Herein, chitosan obtention, physicochemical characteristics, chemical modifications, and interactions with bioactive agents are presented and discussed. Molecular mechanisms involved in chitosan skin protection and recovery are highlighted by overlapping the events orchestrated by the signaling molecules secreted by different cell types to reconstitute healthy skin tissue structures and components.
A Review of Polymeric Micelles and Their Applications
Authors: Perumal Suguna , Atchudan Raji , Lee Wonmok
Published: June 2022

Self-assembly of amphiphilic polymers with hydrophilic and hydrophobic units results in micelles (polymeric nanoparticles), where polymer concentrations are above critical micelle concentrations (CMCs). Recently, micelles with metal nanoparticles (MNPs) have been utilized in many bio-applications because of their excellent biocompatibility, pharmacokinetics, adhesion to biosurfaces, targetability, and longevity. The size of the micelles is in the range of 10 to 100 nm, and different shapes of micelles have been developed for applications. Micelles have been focused recently on bio-applications because of their unique properties, size, shape, and biocompatibility, which enhance drug loading and target release in a controlled manner. This review focused on how CMC has been calculated using various techniques. Further, micelle importance is explained briefly, different types and shapes of micelles are discussed, and further extensions for the application of micelles are addressed. In the summary and outlook, points that need focus in future research on micelles are discussed. This will help researchers in the development of micelles for different applications.
Synthesis of Layered Double Hydroxides with Phosphate Tailings and Its Effect on Flame Retardancy of Epoxy Resin
Authors: Wu Hanjun , Zhang Wenjun , Zhang Huali , Gao Pengjie , Jin Lingzi , Pan Yi , Pan Zhiquan
Published: June 2022

In this work, phosphate tailings (PTs) were used as raw materials for the preparation of Ca-Mg-Al layered double hydroxides (LDHs-1) and Ca-Mg-Al-Fe layered double hydroxides (LDHs-2) by co-precipitation method. The as-prepared samples were characterized by FT-IR, SEM, XRD, and XPS and applied as a flame retardant to improve the fire safety of epoxy resin (EP). The results showed that both LDHs-1 and LDHs-2 exhibited layered structure and high crystallinity. Compared with neat EP, the value of limiting oxygen index (LOI) increased from 25.8 to 29.3 and 29.9 with 8 wt% content of LDHs-1 and LDHs-2, respectively. The flame retardant properties of the composite material were characterized by cone calorimeter (CC), and the results showed that the peak value of the smoke production rate (SPR) decreased more than 45% and 74%, total smoke production (TSP) reduced nearly 64% and 85% with the addition of LDHs-1 and LDHs-2. Meanwhile, the value of the total heat release (THR) reduced more than 28% and 63%. The conversion from LDHs to layered double oxide (LDO) might be conducive to the fire safety of EP. Moreover, the transformation of Fe-OH to Fe-O could promote the early cross-linking of polymer. In summary, LDHs-2 could significantly improve the carbonization process of EP and suppress the smoke released during the combustion process.
A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments
Authors: Awais Muhammad , Aizaz Aqsa , Nazneen Arooba , Bhatti Qurat ul Ain , Akhtar Memoona , Wadood Abdul , Atiq Ur Rehman Muhammad
Published: June 2022

This review focuses on the therapeutic effects of ions when released in physiological environments. Recent studies have shown that metallic ions like Ag+, Sr2+, Mg2+, Mn2+, Cu2+, Ca2+, P+5, etc., have shown promising results in drug delivery systems and regenerative medicine. These metallic ions can be loaded in nanoparticles, mesoporous bioactive glass nanoparticles (MBGNs), hydroxyapatite (HA), calcium phosphates, polymeric coatings, and salt solutions. The metallic ions can exhibit different functions in the physiological environment such as antibacterial, antiviral, anticancer, bioactive, biocompatible, and angiogenic effects. Furthermore, the metals/metalloid ions can be loaded into scaffolds to improve osteoblast proliferation, differentiation, bone development, fibroblast growth, and improved wound healing efficacy. Moreover, different ions possess different therapeutic limits. Therefore, further mechanisms need to be developed for the highly controlled and sustained release of these ions. This review paper summarizes the recent progress in the use of metallic/metalloid ions in regenerative medicine and encourages further study of ions as a solution to cure diseases.
Remote Sensing of Surface and Subsurface Soil Organic Carbon in Tidal Wetlands: A Review and Ideas for Future Research
Authors: Sharma Rajneesh , Mishra Deepak R. , Levi Matthew R. , Sutter Lori A.
Published: June 2022

Tidal wetlands, widely considered the most extensive reservoir of soil organic carbon (SOC), can benefit from remote sensing studies enabling spatiotemporal estimation and mapping of SOC stock. We found that a majority of the remote-sensing-based SOC mapping efforts have been focused on upland ecosystems, not on tidal wetlands. We present a comprehensive review detailing the types of remote sensing models and methods used, standard input variables, results, and limitations for the handful of studies on tidal wetland SOC. Based on that synthesis, we pose several unexplored research questions and methods that are critical for moving tidal wetland SOC science forward. Among these, the applicability of machine learning and deep learning models for predicting surface SOC and the modeling requirements for SOC in subsurface soils (soils without a remote sensing signal, i.e., a soil depth greater than 5 cm) are the most important. We did not find any remote sensing study aimed at modeling subsurface SOC in tidal wetlands. Since tidal wetlands store a significant amount of SOC at greater depths, we hypothesized that surface SOC could be an important covariable along with other biophysical and climate variables for predicting subsurface SOC. Preliminary results using field data from tidal wetlands in the southeastern United States and machine learning model output from mangrove ecosystems in India revealed a strong nonlinear but significant relationship (r2 = 0.68 and 0.20, respectively, p < 2.2 × 10−16 for both) between surface and subsurface SOC at different depths. We investigated the applicability of the Soil Survey Geographic Database (SSURGO) for tidal wetlands by comparing the data with SOC data from the Smithsonian’s Coastal Blue Carbon Network collected during the same decade and found that the SSURGO data consistently over-reported SOC stock in tidal wetlands. We concluded that a novel machine learning framework that utilizes remote sensing data and derived products, the standard covariables reported in the limited literature, and more importantly, other new and potentially informative covariables specific to tidal wetlands such as tidal inundation frequency and height, vegetation species, and soil algal biomass could improve remote-sensing-based tidal wetland SOC studies.
Method for Continuous Integration and Deployment Using a Pipeline Generator for Agile Software Projects
Authors: Donca Ionut-Catalin , Stan Ovidiu Petru , Misaros Marius , Gota Dan , Miclea Liviu
Published: June 2022

Lately, the software development industry is going through a slow but real transformation. Software is increasingly a part of everything, and, software developers, are trying to cope with this exploding demand through more automation. The pipelining technique of continuous integration (CI) and continuous delivery (CD) has developed considerably due to the overwhelming demand for the deployment and deliverability of new features and applications. As a result, DevOps approaches and Agile principles have been developed, in which developers collaborate closely with infrastructure engineers to guarantee that their applications are deployed quickly and reliably. Thanks to pipeline approach thinking, the efficiency of projects has greatly improved. Agile practices represent the introduction to the system of new features in each sprint delivery. Those practices may contain well-developed features or can contain bugs or failures which impact the delivery. The pipeline approach, depicted in this paper, overcomes the problems of delivery, improving the delivery timeline, the test load steps, and the benchmarking tasks. It decreases system interruption by integrating multiple test steps and adds stability and deliverability to the entire process. It provides standardization which means having an established, time-tested process to use, and can also decrease ambiguity and guesswork, guarantee quality and boost productivity. This tool is developed with an interpreted language, namely Bash, which offers an easier method to integrate it into any platform. Based on the experimental results, we demonstrate the value that this solution currently creates. This solution provides an effective and efficient way to generate, manage, customize, and automate Agile-based CI and CD projects through automated pipelines. The suggested system acts as a starting point for standard CI/CD processes, caches Docker layers for subsequent usage, and implements highly available deliverables in a Kubernetes cluster using Helm. Changing the principles of this solution and expanding it into multiple platforms (windows) will be addressed in a future discussion.
Use of direct oral anticoagulants in primary care: a qualitative study integrating patient and practitioner perspectives
Authors: Osasu Yeyenta Mina , Mitchell Caroline , Cooper Richard
Published: June 2022

Background

Older patients with atrial fibrillation (AF) are increasingly offered direct oral anticoagulants (DOACs) to reduce the risk of catastrophic stroke, but clinical follow-up and compliance checks are still required to maintain patient safety. Although a recent qualitative meta-analysis has explored up-to-date research in this area, little is known qualitatively about clinicians’ or patients’ views and experiences of DOAC use in primary care in the UK.

Aim

To understand the experiences of healthcare practitioners and patients in relation to DOAC use in UK primary care.

Design & setting

Semi-structured interviews were undertaken. Sixteen older patients with AF taking DOACs, 10 pharmacists, and six GPs were interviewed in Sheffield, England in 2018.

Method

Interview questions were developed following a systematic literature review. Interviews were audio-recorded, transcribed, and analysed using six-stage thematic analysis.

Results

The integrated perspectives show that all three participant groups preferred DOACs over warfarin, a preference driven mainly by the safety profile compared with warfarin. GPs valued pharmacists' input in anticoagulant care, and pharmacists discussed patient safety in the context of anticoagulant audits, and highlighted the need for continuous patient education and counselling. Medication reviews by pharmacists were seen as a positive contribution to medicines optimisation.

Conclusion

Patients had an overriding trust in their doctors. GPs valued a collaborative approach with other clinicians, and community pharmacists appeared to highlight operational challenges in primary care that may limit the effectiveness of interventions.
ASUHAN BERPUSAT PADA KELUARGA MENINGKATKAN DUKUNGAN KELUARGA DAN KEBERHASILAN PEMBERIAN ASI AWAL
Authors: Supliyani Elin , Handayani Ina , Suhartika Suhartika
Published: June 2022

ABSTRAK

Capaian ASI eksklusif di Indonesia belum mencapai angka yang diharapkan. Menurut data Riskesdas tahun 2018 alasan utama kegagalan pemberian ASI pada bayi 0-5 bulan adalah 68,3 % karena ASI tidak keluar. Proses menyusui akan berjalan optimal jika kondisi fisik dan psikologis ibu dalam keadaan baik. Dukungan keluarga merupakan faktor dominan yang mempengaruhi keberhasilan pemberian ASI. Dukungan dari orang terdekat sangatlah berperan dalam sukses tidaknya menyusui. Model asuhan yang berpusat pada keluarga diperlukan sebagai upaya untuk meningkatkan dukungan dalam memberikan ASI. Tujuan penelitian untuk menganalisa pengaruh model asuhan berpusat pada keluarga terhadap dukungan keluarga dan keberhasilan pemberian ASI awaL. Desain penelitian menggunakan  pre-test post-test control group design, dilakukan di Praktik Mandiri Bidan Kota Bogor. Pengambilan sampel dilakukan secara purposive sampling terhadap 27 responden kelompok intervensi dan 27 kelompok kontrol. Variabel diukur menggunakan instrumen pre-test post-test sebelum dan setelah diberikan perlakuan asuhan kepada keluarga ibu hamil berupa edukasi pentingnya ASI, adaptasi psikologis ibu nifas, pijat oksitosin, cara dan posisi menyusui.  Evaluasi asuhan kepada keluarga dilihat dari dukungan yang dirasakan ibu dan keberhasilan pemberian ASI sampat 7 hari postpartum. Analisa pengaruh model asuhan berpusat pada keluarga terhadap dukungan menggunakan uji Mann-Whitney, sedangkan untuk menganalisa pengaruh asuhan terhadap  pemberian ASI awal menggunakan uji Chi-Squre. Hasil menunjukkan bahwa terdapat pengaruh yang bermakna model asuhan berpusat pada keluarga terhadap dukungan dan  keberhasilan pemberian ASI awal (p<0.001) dan (p =0.017).  Diharapkan model asuhan berpusat pada keluarga  ini dapat diaplikasikan sebagai model  dalam memberikan asuhan kepada ibu hamil agar mendapat dukungan dari keluarga dan berhasil memberikan ASI.

 

Kata Kunci : Asuhan berpusat pada keluarga, Dukungan keluarga, Pemberian ASI
Recidivas de neurocriptococose pós-transplante hepático: relato de caso
Authors: Scopel Miossi Leticia , Vianna Barreto de Fraipont Carolina , Dias Caprini Matheus , Brito Feu Natalia , Zardo Trindade Livia , Carvalhal Moitinho Guilherme , Regina Santana Morelato Bonadiman Carla , Walker de Abreu Isaac , Poltronieri Pacheco Mariana
Published: June 2022

Relato de caso de dupla recidiva de neurocriptococose com o objetivo de divulgar informações e fomentar discussão sobre essa, que é a terceira infecção fúngica mais comum após transplante de órgãos sólidos e que é de difícil manejo e com literatura escassa. Alguns pacientes apresentam resultados desfavoráveis a despeito da instituição de terapia antifúngica, como morte prematura devido às complicações da doença, controle tardio da infecção ou até mesmo não controle da infecção apesar da terapia instituída. Casos refratários apresentam prognóstico pior.
Specificity, Sensitivity and Usefulness Of Neutrophil Lymphocyte Ratio In The Follow-Up Of Patients After Helicobacter Pylori Eradication Treatment
Authors: YILMAZ Gökhan , YİĞİT Ece
Published: June 2022

Objective: The aim of this study is to determine the sensitivity and specificity of the NLR ratio in order to assess treatment effectiveness in the follow-up of patients who are endoscopic H. pylori-positive and administered eradication therapy.

Materials and Methods: The Endoscopy Unit at Istanbul Medipol University Pendik Hospital evaluated 386 individuals who underwent upper gastrointestinal endoscopy. Neutrophil and lymphocyte counts, as well as neutrophil-to-lymphocyte ratios (NLR), were compared in HP positive and negative patients. H. pylori eradication was performed on 205 HP-positive patients using a 2-week triple therapy. All patients had a complete blood count done at the same time, and NLR was computed and compared between the eradicated and non-eradicated groups.

Results: H. pylori eradication was accomplished in 100 (48.7%) of the patients, whereas the stool antigen test was positive in 105 (51.3%) of the patients. There was a statistically significant difference in neutrophil counts (P
Association Between Index of Cardio‐Electrophysiological Balance and Cardiac Remodeling
Authors: DURAN Mustafa , ÖZEN Mehmet Burak , BÜYÜKTERZİ Zafer
Published: June 2022

Objective: Pathophysiological changes in response to myocardial infarction (MI) result in cardiac remodeling. Left untreated this pathologic process contributes to impairment of ventricular function and development of malignant ventricular arrhythmias. Recently introduced ECG‐based marker index of cardio‐electrophysiological balance (iCEB) has been shown to be associated with various cardiac conditions. Herein, we aimed to investigate the association between the iCEB and cardiac remodeling in post-MI patients.

Materials and Methods: Patients aged ≥18 years presenting with acute MI who underwent successful percutaneous coronary intervention between January 2020 and January 2021 were recruited. Regarding the assessment of cardiac remodeling, left ventricular (LV) mass, LV mass index (LVMI), and relative wall thickness (RWT) were measured before the start of treatment and six months after the procedure along with the QT/QRS ratio (iCEB), and QTC/QRS ratio (iCEBc).

Results: According to our study, estimated QT/QRS (iECB) and QTc/QRS (iECBc) ratios were found to be significantly lower at six-month follow-up compared to baseline values (4.73∓0.60 vs 4.62∓0.55 & 4.93∓0.59 vs 4.78∓0.55, p
Is Elderly-Onset Rheumatoid Arthritis Different From Younger-Onset Rheumatoid Arthritis?
Authors: DURMAZ Yunus , İLHANLI İlker , USTUN CETİNKAYA Betul , CENGİZ Kıvanç
Published: June 2022

Objectives: To compare elderly-onset rheumatoid arthritis (EORA) patients with younger-onset rheumatoid arthritis (YORA) patients in terms of sociodemographic, clinical and radiological features, and treatment responses.

Materials and Methods: 422 rheumatoid arthritis (RA) patients were evaluated retrospectively. Patients with the age of onset of disease symptoms ≥60 were considered EORA, and those 0.05).

Conclusion: There is no difference in many clinical and laboratory findings, especially disease activity scores and radiographic scores, in patients with EORA and YORA.
Çocuklarda Helicobacter pylori Enfeksiyonunda Risk Faktörleri ve Klinik Bulgular
Authors: ERDEMİR Gülin , ÖZKAN Tanju , ÖZGÜR Taner , ARSOY Hanife Ayşegül , ÇAKAR Sevim
Published: June 2022

Giriş ve Amaç: Helicobacter pylori(H.pylori) enfeksiyonu tüm dünyada en yaygın kronik enfeksiyonlardan biridir. Gelişmekte olan ülkelerde bulaş genellikle çocukluk döneminde olmaktadır. Düşük sosyoekonomik seviyede yaşayanlarda daha sık görülmektedir. Tamamen asemptomatik olabileceği gibi, gastrointestinal ve ekstraintestinal semptomlarla karşımıza çıkabileceği de bilinmektedir. Bu çalışmada çocuklarda H.pylori seroprevalansının saptanması, risk faktörleri ve semptomların değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: Çalışmaya Bursa ilinde beş farklı ilköğretim okulundan randomizasyonla 6-16 yaş arası 489 öğrenci alındı. Kabul eden ailelerden sosyoekonomik bilgileri ve çocuklarındaki semptomları sorgulayan anketleri doldurmaları istendi. Okullara gidilerek çocukların antropometrik ölçümleri yapıldı. H.pylori İmmunglobulin G (IgG) çalışılmak üzere çocuklardan 5 ml kan örneği alındı. Çocuklar H.pylori IgG pozitifliğine göre 2 gruba ayrılarak sosyoekonomik özellikler ve semptomlar karşılaştırıldı.

Bulgular: Çalışmaya 489 öğrenci alındı, %48,7 kız ve %51,3 erkekti. Yaş ortalaması 9,9±2,3 yıldı. H. pylori seropozitifliği %44 çocukta saptandı. Kızların %52,1’i, erkeklerin %36,3’ü seropozitif bulundu (p=0,0001). Sosyoekonomik faktörlerden babanın eğitim düzeyi azaldıkça çocukta H. pylori sıklığının arttığı saptandı (p=0,005). H. pylori seropozitif olanlarda boy ve vücut ağırlığı Z skorları negatif olanlara göre anlamlı olarak düşüktü (p=0,012 ve p=0,03;sırasıyla). Yaş gruplarına göre bakıldığında H.pylori seropozitiflerde 6-10 yaşta vücut ağırlığının ( p=0,03), 10 yaşından büyüklerde ise boy uzunluğunun (p=0,04) daha geri olduğu saptandı.

Sonuç: Bursa ilinde ilköğretim çağında saptanan H.pylori seropozitivite sıklığı Türkiye verileri ile uyumludur. Vücut ağırlığı ve boy uzunluğunun seropozitiflerde daha geri olduğu görülmüştür. Seropozitivitenin 10 yaştan küçük çocuklarda vücut ağırlığını, 10 yaştan büyük olanlarda ise boy uzunluğunu ön planda etkilediği görülmüştür. Sonuç olarak çocuklarda H.pylori, bulaş sonrası asemptomatik kalabilen ancak çocuklarda büyümeyi olumsuz etkilediği unutulmaması gereken önemli bir faktördür.
LİPÖDEMDE SUBKÜTAN YAĞ DOKUSU KALINLIĞI İLE ADİPOKİNLER ARASINDAKİ İLİŞKİ
Authors: ÜNLÜ Zeliha , ÇAVUŞOĞLU Tuğba , KOSOVA Funda , AYDIN Ali
Published: June 2022

Giriş ve Amaç: Adipokinler ve disfonksiyonel yağ dokusu arasındaki ilişkide subkutan yağ dokusundan ziyade viseral yağ dokusundaki değişikliklerin rolüne dikkat çekilmiştir. Özellikle cilt altı yağ dokusunun etkilendiği lipödemde adipokinler hakkında bilgi yetersizdir. Bu çalışmada lipödemli hastalarda adiponektin, ghrelin, resistin ve visfatin düzeylerinin ve bunların yağ doku kalınlığı ile ilişkisinin araştırılması amaçlandı. Bu amaçla cilt altı yağ dokusu kalınlığı ultrasonografi ile objektif olarak değerlendirildi.

Gereç ve Yöntemler: Lipödem tanısı almış toplam 19 kadın hasta ve yaş farkı olmayan 15 sağlıklı kadın çalışmaya dahil edildi. Deri ve deri altı yağ dokusu kalınlıkları ultrasonografik olarak ölçüldü. Tüm deneklerin serum adiponektin, ghrein, resistin ve visfatin seviyeleri sandviç ELISA protokolü kullanılarak ölçüldü.

Bulgular: Lipödemli hastalarda, uyluk ve baldırda subkutan subkutan doku kalınlığı ve toplam deri-subkutan kalınlığı kontrollere kıyasla, uyluktaki deri kalınlığı dışında önemli ölçüde arttı (P0.05). Lipödemli hastalarda ve kontrollerde ultrason ile adiponektin, ghrelin, resistin ve visfatin ile deri, deri altı ve toplam kalınlık ölçümleri arasında anlamlı bir ilişki bulunmadı (P>0.05). İstatistiksel olarak anlamlı olmasa da detaylı incelendiğinde adipokinler ve ultrason ölçümleri arasındaki ilişkide gruplar arasında pozitif veya negatif korelasyonlar gözlendi.

Sonuç: Bulgularımıza göre, serum adipokin düzeyleri ile deri altı yağ dokusu kalınlığı arasında anlamlı bir ilişki bulunmamakla birlikte, tamamen ilgisiz oldukları tartışmalıdır. Daha geniş serilerde yapılacak çalışmalar adipokinlerin cilt altı doku kalınlığı ile ilişkisine ve ultrasonografinin önemine ışık tutacaktır.
Recent Advances in Carbon-Based Adsorbents for Adsorptive Separation of Light Hydrocarbons
Authors: Wang Yong-Sheng , Zhang Xue-Jie , Ba Ya-Qi , Li Tian-Yi , Hao Guang-Ping , Lu An-Hui
Published: June 2022

Light hydrocarbons (LHs) separation is an important process in petrochemical industry. The current separation technology predominantly relies on cryogenic distillation, which results in considerable energy consumption. Adsorptive separation using porous solids has received widespread attention due to its lower energy footprint and higher efficiency. Thus, tremendous efforts have been devoted to the design and synthesis of high-performance porous solids. Among them, porous carbons display exceptional stability, tunable pore structure, and surface chemistry and thus represent a class of novel adsorbents upon achieving the matched pore structures for LHs separations. In this review, the modulation strategies toward advanced carbon-based adsorbents for LHs separation are firstly reviewed. Then, the relationships between separation performances and key structural parameters of carbon adsorbents are discussed by exemplifying specific separation cases. The research findings on the control of the pore structures as well as the quantification of the adsorption sites are highlighted. Finally, the challenges of carbonaceous adsorbents facing for LHs separation are given, which would motivate us to rationally design more efficient absorbents and separation processes in future.
Ceramic implants - towards a stronger evidence base - Opinion Paper​
Authors: Chen Andre
Published: June 2022

Commonly lost among personal preferences and scattered clinical results, ceramic implants have been commonly regarded as a therapeutic solution “of last recourse”, “holistic only” or “if the patient is allergic” procedures.
While the clinical possibility of mechanical breakdown and the phantom of breakage and catastrophic failure has always been present, the aesthetic qualities of ceramic have been widely lauded.
With alumina and other materials were randomly failing in clinical trials, the use of titanium reached new heights during the 90´s and early 2000´s.
The 1981 Toronto conference set the tone for the development of new titanium surfaces, connections, and microgeometries, transforming dental practice and clinical protocols.
In a quest to dominate the titanium dental implant market, it was an era of ambitious organizations such as NobelBioCare ™, Straumann ®, Astratech ®, Dentsply Sirona, Biomet 3i ® among others.
Survival curves shot up to 98% and osseointegration time was cut in half (88/89 % for the machined Branemark implant).
The “Titanium train” had left the station, more of a TGV than a steam locomotive with brand and market share (and demand from clinics) ruling out any possibility of the use of an alternative biomaterial.
PENGEMBANGAN SISTEM PEMBANGKIT LISTRIK TENAGA SURYA (PLTS) TERHUBUNG JARINGAN DI LABORATORIUM ENERGI TERBARUKAN MENGGUNAKAN PVSYST
Authors: Daud Aceng , Rachbini Ribhy , Hernawan Kholiq
Published: June 2022

Politeknik Negeri Bandung merupakan salah satu perguruan tinggi vokasi yang memiliki beberapa pembangkit listrik alternatif. Diantaranya, Pembangkit Listrik Tenaga Surya (PLTS) yang berada di laboratorium surya berkapasitas 18 kWp yang dioperasikan secara offgrid,. Dimana energi yang dihasilkan oleh Pembangkit Listrik Tenaga Surya (PLTS) tersebut tidak dimanfaatkan dengan baik karena banyak energi yang terbuang dan tidak tertampung oleh sistem baterai . Oleh karena itu dengan mengsinkronisasikan Pembangkit Listrik Tenaga Surya (PLTS) dengan jaringan PLN maka listrik yang dihasilkan dapat disalurkan ke jaringan PLN sehingga menghasilkan keuntungan berupa penghematan energi dan penghematan biaya. Perancangan PLTS Lab.Surya terhubung dengan jaringan PLN dilakukan dengan menggunakan Inverter Sunny Mini Central 5000A dan software PVSyst yang menghasilkan total  energi sebesar 22,9 MWh/tahun yang disalurkan ke beban sebesar 17,639 MWh dan yang disalurkan ke jaringan PLN yaitu sebesar 5,260 MWh pertahun, sehingga penghematan biaya yang didapatkan dalam 1 tahun apabila kondisi PLTS ongrid berbeban yaitu sebesar Rp. 3.364.296 dengan persentase penghematan energi dan biaya sebesar 0,31% sedangkan jika semua energi listrik yang dihasilkan PLTS disalurkan ke PLN penghematan yang didapatkan sebesar  Rp. 14.646.840 per tahun dengan persentase  penghematan energi dan biaya sebesar 1,37% dari beban biaya PLN yang harus dibayar.
ANALISIS KINERJA TURBIN UAP UNIT 1 DI CIREBON POWER
Authors: Setiawan Fadel , Melkias Alvera , Slameto
Published: June 2022

Cirebon Power merupakan salah satu PLTU dengan tipe supercritical yang terletak di Jawa yang mempunyai kapasitas sebesar 660 MW. Komponen penting PLTU yang digunakan untuk membangkitkan listrik diantaranya adalah turbin uap yang berfungsi untuk merubah energi kalor menjadi energi mekanik. PLTU Cirebon Power menggunakan tipe turbin tandem compound, single reheat. Parameter kinerja dari turbin uap dapat ditinjau dari heat rate, efisiensi termal dan efisiensi isentropik. Turbine heat rate merupakan parameter yang menunjukan jumlah energi yang dibutuhkan untuk menghasilkan satu kilowatthour (kWh) listrik. Efisiensi adalah rasio kerja yang dilakukan oleh mesin dengan total kerja yang dimasukkan ke dalam mesin. Untuk mencari parameter-parameter tersebut dapat menggunakan metoda langsung. Nilai turbin heat rate aktual terendah ada pada bulan Januari sebesar 7909,33 kJ/kWh dan tertinggi pada bulan April sebesar 8116,52 kJ/kWh. Efisiensi termal tertinggi pada bulan Januari sebesar 45,52% dan tertinggi pada bulan April sebesar 44,36%. Efisiensi isentropik turbin LP sebesar 90,53-91,10%, turbin IP sebesar 86,46-86,76%, turbin HP dengan nilai 81,25 – 82,73%.
Az „euro-iszlám” modelljei az európai muszlimok identitáscsoportjaiban
Authors: Wollner Márta
Published: June 2022

Ez a tanulmány az európai muszlim kisebbség néhány karakteres jellemzőjét elemzi. A demográfi ai jellemzők után bemutatja az őshonos arab politikai mezőben ismert kettős (valós és virtuális) társadalmi teret, és az integrációs folyamatra gyakorolt gátló, vagy támogató hatását. Elemez – a kisebbségi identitások önkéntes választásának tipológiáját használva – két jellegzetes kategóriát, az „etnikai/vallási büszkeség” és a „kozmopoliták” csoportját. Végül bemutat három versengő „euro-iszlám” értelmezést, Júszuf al-Qaradáwi (a továbbiakban Qaradáwi) „kisebbségi vallásijog” (fi qh al-aqallíja), Tariq Ramadan szalafi ta reform-„muszlim demokrácia” és Bassam Tibi „liberális-szekularizált euroiszlám” koncepcióját. Ezen értelmezési keretek az európai muszlim identitások gondolati kereteinek megformálására törekvő kezdeményezések, melyek az iszlám belső struktúráiból indulnak, és feltehetően meghatározzák majd az „euro-iszlám” koncepciók jövőbeli változatait.
Városi terek Európában
Authors: Izsák Éva
Published: June 2022

A földrajzi tér átalakítása időben változó folyamat. A kontinentális terület jelöli ki azokat a tér-részeket, amelyek alkalmasak az ember által átalakított környezet birtokba vételére. Földünk felszínének jelentős része vízfelület, amely kevéssé alkalmas állandó emberi életre. Szárazföldek benépesítése és lakhatóvá tétele mindig nagy kihívás volt az emberiségnek. Technikai fejlődés határozta meg az életteret. A rendelkezésre álló természet átalakítása hatalmas feladatot jelentett az emberiségnek. A tanulmány műfaja tudományos esszé. Bemutatja az elmúlt évszázad európai városfejlődésének térbeli folyamatait, elemzi a természet és tér viszonyának lehetőségeit, valamint a század történelmét kiemelve bemutatja geopolitika és város viszonyrendszerét. A transzkontinentális terek város fejlődésre gyakorolt hatását vizsgálja. Az esszét színesíti Frans Masereel Th e City című könyvében megjelent fametszeteinek több reprodukciója.
April 25 – the world malaria day
Authors:   Institute of Disinfectology of the Federal Scientific Center of Hygiene named after F.F. Erisman, Roslavtseva Svetlana Aleksandrovna
Published: June 2022

The data on the history of the disease "malaria" from the18th century until 2022, on the malaria causative agents and their Anopheles vectors, on the occurrence of epidemics and pandemics of malaria reviewed briefly. Data on the importation of malaria pathogens from abroad, on "airfield malaria" and methods of suppressing flying insects in aircraft cabins; on the increase in mosquito numbers and the increase in the malaria morbidity also provided. Keywords: malaria, vector mosquitoes, malaria plasmodia, outbreaks, larvicides.
Informational-methodological letter "Analysis of The morbidity of pediculosis in the Russian Federation and the use of modern pediculicides for its treatment and prevention (as of 01.01.2022)"
Authors:   Institute of Disinfectology Federal Budgetary Institution of Science ", Lopatina Yuliya Vladimirovna ,   Federal Scientific Center for Hygiene named after F.F. Erisman of Rospotrebnadzor, Roslavtseva Svetlana Aleksandrovna ,   Institute of Disinfectology Federal Budgetary Institution of Science "Federal Scientific Center for Hygiene named after F.F. Erisman of Rospotrebnadzor, Cherepanova Evgeniya Aleksandrovna ,   Federal Budgetary Institution of Health Care "Federal Center for Hygiene and Epidemiology" of Rospotrebnadzor, Chirova Alina Viktorovna ,   Federal Budgetary Institution of Health Care "Federal Center for Hygiene and Epidemiology" of Rospotrebnadzor
Published: June 2022

The morbidity of human lice in the Russian Federation in 2016–2021 was analyzed. High intensive infection rates were registered in the Central, Northwestern and Far Eastern Federal Districts. The maximum level of pediculosis infestation of the population was noted in Moscow (88.7–96.1 % of all cases of this disease in the Central Federal District). The resistance of lice to permethrin led to a decrease in the pediculicidal activity of pediculicides based on it. The range of modern drugs effective against permethrin-resistant head and body lice and the dynamics of the ratio of pediculicides based on substances from different groups of insecticides during 1991–2021 were analyzed. Keywords: pediculosis, Pediculus humanus, resistance, pyrethroids, pediculicides.
spielen
Essenz der Potential-Entfaltung des Menschen
Authors: Weyland Beate , Strasser Rosa
Published: June 2022

Auch wenn die UN-Kinderrechts-Konvention Spielen als Recht der Kinder verankert, sieht die Realität oft anders aus. Beate Weyland und Rosa Strasser rufen die Qualität des freien Spiels in Erinnerung und plädieren dafür, dass Raum und Zeit dafür auch in Bildungseinrichtungen geschaffen werden.
Lotus maritimus L. (Fabaceae), alien species new to Lithuania
Authors: Petrulaitis Lukas
Published: June 2022

Information about the first record of alien species Lotus maritimus L. (Fabaceae) in Lithuania is provided. This species was found in disturbed grassland along the railway line in Panevėžys district (northern part of Central Lithuania), Berčiūnai village in June 2021. It is supposed that seeds of this species have been accidentally introduced with rock material used to maintain railway embankment. Species composition of the habitat in Lotus maritimus locality is presented. The recorded population consists of a large number of generative individuals. This species could also grow in other parts of Lithuania, as the plants produce viable seeds and might spread to new areas. Currently, Lotus maritimus is considered as a casual species in Lithuania; however, it may naturalise locally in the future.
IMPLEMENTASI KEBIJAKAN TENTANG PENGANGKATAN PEGAWAI NEGERI SIPIL DALAM JABATAN FUNGSIONAL MELALUI PENYESUAIAN/INPASSING DI LINGKUNGAN PEMERINTAH KABUPATEN BARITO SELATAN
Authors: Mahpuzah Siti , Amberi Muslih , Syafari M Riduansyah
Published: June 2022

Kebijakan inpassing dalam jabatan fungsional merupakan salah satu instrumen dari berbagai upaya pemerintah untuk mewujudkan Aparatur Sipil Negara yang profesional Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif dengan pendekatan kualitatif. Data dikumpulkan melalui wawancara, dokumentasi dan observasi dengan subjek penelitian adalah pelaksana kebijakan dan PNS yang menerima dampak dari kebijakan. Hasil penelitian memberikan gambaran bahwa implementasi kebijakan inpassing jabatan fungsional telah berjalan meski tidak menunjukkan perkembangan yang signifikan dan secara struktur organisasi inpassing memberikan dampak yang positif. Faktor-faktor pendukung implementasi kebijakan tentang pengangkatan Pegawai Negeri Sipil dalam jabatan fungsional melalui penyesuaian/inpassing adalah waktu pelaksanaan inpassing yang diperpanjang, kebijakan pemerintah yang mengharuskan pekerjaan tertentu hanya boleh dilaksanakan oleh pejabat fungsional dan dukungan RPJMD Kabupaten Barito Selatan sedangkan faktor penghambat implementasi kebijakan ini adalah sosialisasi yang relatif minim, proses pengangkatan dalam jabatan fungsional yang memerlukan waktu lama dan persyaratan yang tidak mudah dan pemahaman terhadap jabatan fungsional yang minim Sejalan dengan hasil penelitian tersebut maka kebijakan inpassing akan mampu memberikan hasil yang optimal apabila sosialisasi terhadap kebijakan tersebut juga dilakukan secara optimal disamping good will pemerintah, baik pemerintah pusat dan pemerintah daerah dalam melaksanakan kebijakan tersebut secara terpadu dari pusat sampai di daerah.

Kata kunci : Implementasi, Penyesuaian/Inpassing
ANALISA PENURUNAN AKIBAT BEBAN TIMBUNAN PADA TANAH GAMBUT DENGAN PERKUATAN
Authors: Zebua Henry Fortumey
Published: June 2022

Semakin tingginya penggunaan lahan tanah sebagai tempat pemukiman atau konstruksi bangunan sipil lainnya mengakibatkan pemanfaatan lahan dengan tanah lunak seperti tanah gambut. Tanah gambut memiliki sifat-sifat yang kurang baik untuk konstruksi bangunan. Tanah gambut mempunyai sifat daya dukung tanah yang rendah, kadar air yang tinggi, dan kompresibilitas yang besar membuat tanah ini mengalami penurunan yang besar dan dalam waktu yang sangat lama. Proses penurunan tanah memerlukan waktu yang lama agar penurunan berhenti atau stabil dan tidak dapat diketahui kapan waktunya jika hanya dari pengamatan. Oleh karena itu perlu analisis untuk memperkirakan penurunan akibat beban timbunan pada tanah gambut. Metode perhitungan untuk memprediksi penurunan menggunakan metode hiperbolik, metode asaoka, dan metode hiperbolik modifikasi. Data penurunan yang digunakan adalah data sekunder dari penelitian sebelumnya oleh wisnu (2019). Dimana sampel penurunan antara lain perkuatan grid, perkuatan grid dengan tiang bambu 10 cm, perkuatan grid dengan tiang bambu 15 cm, perkuatan grid dengan tiang bambu 25 cm, dan perkuatan grid dengan tiang bambu 30 cm. Hasil prediksi penurunan menggunakan metode hiperbolik, metode asaoka, dan metode hiperbolik modifikasi mendekati sama dengan hasil pengamatan. Hasil prediksi penurunan dengan metode hiperbolik dan metode hiperbolik modifikasi mengalami penurunan yang lebih kecil dibandingkan metode asaoka. Metode yang efektif digunakan untuk memprediksi penurunan akhir pada penelitian ini adalah metode hiperbolik modifikasi.
APLIKASI ORGANISASI LINIER SEBAGAI SOLUSI KETERBATASAN RUANG DI DETHRONE ULTIMATE E-SPORT ARENA
Authors: Cahyadi Nyoman Goris , Artayasa I Nyoman
Published: June 2022

Berkembangnya ekosistem eSport di Indonesia sejalan dengan pertumbuhan tempat-tempat untuk melaksanakan kegiatan tersebut, seperti DeThrone Ultimate eSport Arena yang merupakan eSport Arena yang cukup besar di area Denpasar karena dapat menampung kurang lebih 100 orang dengan keluasan 237,5 m2. Untuk menampung 100 orang dengan fasilitas pendukungnya, seharusnya membutuhkan ruang minimal sebesar 250 s/d 300 m2. Peneliti ingin meneliti desain penataan ruang dan fasilitas yang dimiliki oleh objek kasus tersebut, agar peneliti mengetahui cara DeThrone Ultimate eSport Arena dalam mensiasati keterbatasan ruang. Metode yang digunakan pada penelitian ini merupakan metode kualitatif, dengan metode pengumpulan data berupa literasai, observasi, wawancara, dan dokumentasi. Hasil dari penelitian ialah dengan mengkomposisikan fasilitas ruang yang menggunakan desain custom furniture, yaitu berupa meja komputer dengan bentuk yang memanjang dan saling berhadapan satu sama lain, serta penempatan fasilitas ruang yang menempel pada bagian dinding juga berfungsi untuk meminimalisir ruangan yang terbuang.
ANALISIS KREDIT CALON DEBITUR MENGGUNAKAN METODE FUZZY TSUKAMOTO
Authors: Patriya Eka , Sutanty Ety , Handayani  , Siregar Meilani B. , Setiyaningsih Esti
Published: June 2022

Bank sebagai salah satu lembaga keuangan di Indonesia yang berbentuk bank memberikan jasa keuangan dengan menggunakan prinsip-prinsip perbankan. Bank SENDIRI menyediakan berbagai jenis fasilitas kredit, salah satunya Kredit Multi Guna. Saat ini proses analisis pengajuan kredit di Bank dilakukan dengan menggunakan Sistem Electronic Loan, akan tetapi ketika sistem bermasalah maka proses analisis kredit dilakukan dengan cara manual oleh analis. Tentu saja hal ini mengakibatkan proses analisis kredit membutuhkan waktu. Pada penelitian ini peneliti mengimplementasikan diimplementasikan penggunaan metode fuzzy tsukamoto dalam menganalisis kelayakan kredit calon debitur Bank. Proses analisis kredit pada penelitian ini menggunakan 3 variabel yaitu pekerjaan, Debt Service Ratio (DSR) yang merupakan perbandingan antara angsuran kredit dengan penghasilan, serta kolektabilitas. Masing-masing variabel memiliki 3 himpunan fuzzy dan aturan yang terbentuk adalah sebanyak 27 aturan. Kelayakan KMG calon debitur pada penelitian ini menggunakan hasil dari proses defuzzifikasi. Hasil ujicoba menunjukkan, implementasi fuzzy tsukamoto berdasarkan variabel, DSR, dan kolektabilitas berhasil menghasilkan keputusan kelayakan fasilitas kredit calon debitur Bank dari hasil defuzzifikasi. Hasil penelitian ini diharapkan dapat mempermudah analis dalam melakukan proses analisis pemutusan kredit calon debitur Bank.
IDENTIFIKASI PENYAKIT PNEUMONIA BERDASARKAN CITRA CHEST X-RAY MENGGUNAKAN CONVOLUTIONAL NEURAL NETWORK
Authors: Ekananda Nadya Putri , Riminarsih Desti
Published: June 2022

Perkembangan teknologi digital telah mempengaruhi banyak bidang. Salah satunya dalam bidang kesehatan. Teknologi digital dalam bidang kesehatan banyak digunakan untuk menganalisis organ tubuh manusia bagian dalam yang sulit dilihat, menemukan obat yang tepat untuk mengobati penyakit, mendiagnosa penyakit dan masih banyak lagi. Salah satu hasil pemeriksaan yang dimanfaatkan oleh teknologi adalah hasil citra X-ray. Penyakit yang menggunakan hasil citra X-ray salah satunya adalah pneumonia. Pneumonia adalah infeksi akut pada jaringan paru-paru (alveoli). Gejala pneumonia adalah demam, sesak nafas, dahak berwarna kehijauan, serta gambaran hasil chest X-ray memperlihatan kepadatan pada bagian paru. Hasil citra chest X-ray diperiksa secara manual dan membutuhkan pencahayaan yang baik oleh dokter. Oleh karena itu, tujuan penelitian ini adalah mengimplementasikan algoritma Convolutional Neural Network (CNN) untuk mengidentifikasi penyakit pneumonia berdasarkan citra chest X-ray yang didahului dengan peningkatan kualitas citra menggunakan histogram equalization. Pada model convolutional neural network ini digunakan 5.879 citra chest X-ray, diantaranya 5.255 citra chest X-ray untuk pelatihan dan 624 citra chest X-ray digunakan untuk pengujian. Pada proses pelatihan model diperoleh tingkat akurasi sebesar 97,16%. Pada pengujian model diperoleh tingkat akurasi sebesar 88.46%.
MERGERS AND ACQUISITIONS AS A COMPONENT OF MANAGEMENT OF ECONOMIC SECURITY IN THE CONDITIONS OF INSTABILITY OF GEOPOLITICAL SITUATION
Authors: Gonchar Viktoriya , Kalinin Oleksandr , Polupanova Kateryna
Published: June 2022

Introduction Today there is a new trend in geopolitical architecture: on the one hand there are some trends in the introduction of protectionism and / or even isolationism in global processes, on the other hand global trends continue to increasingly influence economic and social activity of communities around the world. Security issues are becoming increasingly important over time and this is important not only in terms of politics and defense but also the economy. That is why it is necessary to consider new markets, especially during their formation and even unattractive from an investment point of view. This is exactly the Ukrainian market and one of the elements of improving its investment attractiveness is the intensification of mergers and acquisitions.
Purpose The purpose of this article is to study the Ukrainian trends in the management of mergers and acquisitions in the context of national economic security. The task of the article is to study the theoretical aspects of management and planning of mergers and acquisitions and their positive impact on the economic security of the country; analyze the strategies used by enterprises in concluding such agreements; develop solutions to improve the country's economic security management system.
Method (methodology) The following general scientific methods were used in the research process: analysis and synthesis, grouping and systematization of identifying the essence of economic security and mergers and acquisitions, their structure, principles of formation, development of the concept of diagnosing the effectiveness of investor attraction systems and control; inductions and deductions - to generalize the theoretical aspects of the peculiarities of the formation of economic security; statistical and economic - to assess the effectiveness of mergers and acquisitions.