bluuebunny/crossref_metadata_2025 huggingface dataset:
Duplicates under the hammer: natural-history auctions in Berlin's early nineteenth-century collection landscape
Authors: MacKinney Anne Greenwood
Published: March 2022

The nineteenth-century museum and auction house are seemingly distinct spaces with opposing functions: while the former represents a contemplative space that accumulates objects of art and science, the latter provides a forum for lively sales events that disperse wares to the highest bidders. This contribution blurs the border between museums and marketplaces by studying the Berlin Zoological Museum's duplicate specimen auctions between 1818 and the 1840s. It attends to the operations and tools involved in commodifying specimens as duplicates, particularly the auction catalogue. The paper furthermore contextualizes the museum's sales in a broader history of duplicate auctions across Berlin's collection landscape.
The Lesbian, Gay and Bisexual Vote in a More Tolerant Canada
Authors: Guntermann Eric , Beauvais Edana
Published: March 2022

Research on the political preferences of lesbian, gay and bisexual (LGB) voters shows that they are more progressive than heterosexuals. However, few studies consider differences between heterosexual, gay/lesbian, and bisexual men and women. Furthermore, little is known about how these preferences have changed as society has become more accepting of diverse sexualities. We offer an analysis of Canadian LGB voters’ political preferences a decade and a half after same-sex marriage was legalized. Consistent with prior research, we find that gay men, and, to a lesser extent, bisexual men, are more left-wing than heterosexual men. A more novel finding is that bisexual women are the most left-wing group. Lesbian women are only slightly to the left of heterosexual women. While left-wing bisexual women are growing in number, the overall gap between LGB and heterosexual voters has remained stable across generations, because marriage narrows some of the preference gaps.
HOW TO IDENTIFY INSIDERS AND INTRUDERS DISGUISING AS INVESTORS IN THE ASSIGNMENT OF INVESTMENTS
Authors: Ren Raphael , Shan Soh Lip
Published: March 2022

The constant exchange of investment assets poses a risk of ‘commoditisation’ of investment treaty claims. Nevertheless, both traditional and modern investment treaties contain sufficient safeguards against attempts by host State ‘insiders’ and third State ‘intruders’ to create artificial access to arbitration. First, the definition of ‘investment’ can filter genuine investments from bare acquisition of assets (ratione materiae). Second, the textual linkage between ‘investor’ and ‘investment’ strongly implies that ‘active contribution’ in the investment is required from assignees to qualify for protection (ratione personae). Third, the doctrine of abuse of rights prevents treaty shopping and internationalisation of domestic disputes (ratione temporis).
Temporal variabilities of soil carbon dioxide fluxes from cornfield impacted by temperature and precipitation changes through high-frequent measurement and DAYCENT modelling
Authors: Lai Liming , Kumar Sandeep , Rastogi Deeksha , Ashfaq Moetasim
Published: March 2022

Soil carbon dioxide (CO2) emissions from the field of corn (Zea maysL.) play an important role in global warming. This study investigated temporal variability of soil CO2fluxes (Rs) with soil temperature (Ts) and moisture (θ) and built DAYCENT models for predicting future impacts of climate changes onRsusing the measured high-frequency data.Rstrend was tested by Mann–Kendall and Sen Estimator. PredictedRss under different climate scenarios were compared using Parallel-line Analysis. The findings indicated that dailyRsexponentially increased withTsconstrained byθ. During theθof 27–31%, there was a strong exponential relationship betweenRsandTs, but the relationship was weaker for theθof 38–41% and 22–26%. Soil environmental index (SEI,Ts×θ) significantly impactedRswith linear regressionRs0.5= 0.4599 + 0.002059 × SEI in 2008, 2009 and 2011. At the diurnal scale, there were different trends inRss and relationships amongRsandTsandθin different years. Predicted yearlyRss, rootRss and corn yield in 2014–2049 increased with an increase in temperature scenarios, but theRss significantly increased as temperature rose by 1°C or higher. Predicted yearlyRss, rootRss and yield reduced with precipitation scenario increase, and the rootRss and yield significantly diminished as precipitation increased by 15 and 30%. Predicted yearlyRsfrom cornfields had a significantly increasing trend. Future research is needed to explore methods for mitigating cornfieldRsand evaluating sensitivities of different croplandRss to temperature changes.
Five further species of Graphis reported new to Europe from Portugal
Authors: Lepista Zacarias , Aptroot André
Published: March 2022

Five Graphis species are reported as new to Europe from the Mata Nacional do Buçaco, a region in Portugal where graphidoid Graphidaceae are abundant and diverse. The following species were identified: Graphis dendrogramma, G. duplicata, G. gonimica, G. librata and G. pyrrhocheiloides. An updated key is given to the Graphis species known from Europe. All those newly reported were identified with names corresponding to tropical species.
Informal diplomacy in Chosŏn Korea and new engagement with the West and Westernized Japan, 1873–1876
Authors: Han Sean S.
Published: March 2022

This article focuses on Chosŏn's informal diplomacy with the Qing dynasty that guided Chosŏn Korea's diplomatic engagement with Japan in the 1870s. The Chosŏn–Qing literary correspondence in Kang Wi's (姜瑋, 1820–1884) brush talk records has been viewed as historical evidence of Chosŏn's intelligence-gathering activities which formed the basis of a new diplomatic enterprise for dealing with modern imperial powers. What has received less attention, however, is the implementation and implications of the informal diplomacy reflected in Kang's diplomatic activities and his discursive practice. Based on a personal and unofficial account by an intellectual on the margins of the established social and international order, this study revisits the political and intelligence-gathering processes that led up to the 1876 peace agreement, which was the culmination of the Qing and Chosŏn dynasties’ concerted efforts as they transitioned to a changing world order in East Asia. In addition, this article further illuminates Kang's agency, despite his secondary social status, in Chosŏn's changing attitude towards Westerners and Westernized Japan. I argue that as both interviewer and transcriber, and from his position on the periphery of the Confucian ruling elites in the late Chosŏn period, Kang provided a new framework through which to formulate policies by reconfiguring his brush talk records to implement his own agenda as a member of the chungin (middle people) literary elite.
Grant Writing and the Hidden Curriculum: Mentoring and Collaborating Across Disciplines
Authors: Windsor Leah C. , Kronsted Christian
Published: March 2022

Submitting grant proposals is becoming an increasingly common expectation—and, in some cases, a requirement—in the discipline of political science as well as other social sciences and the humanities. However, writing a grant with a good chance of success at getting funded is not part of standard mentorship or pedagogy in our discipline. It is a part of the hidden curriculum, where grant-writing skills often are taught informally in working with a principal investigator. This article describes the process and structure of writing a grant to provide a roadmap for scholars to follow in submitting externally funded projects. The article describes an Institutional Review Board–approved survey about mentorship and grant writing and discusses the importance of socialization, professionalization, and administration in supporting scholars in writing and obtaining grants.
Tick, Tick, Boom: Simulating Human Rights Decisions in the Classroom
Authors: Watson K. Anne
Published: March 2022

This article presents an original simulation, called Tick, Tick, Boom, which is designed to help students examine the use of torture in counterterrorism interrogations. The simulation is designed to be embedded in a larger array of course content but needs only one 50-minute class period to play. Unlike many similar games, students participate individually, learning the consequences of their actions through dice rolls. The article summarizes the gameplay and debriefing, presents a brief assessment of the simulation as an activity, and offers suggestions for future extensions.
Association between dietary patterns and stroke in patients with type 2 diabetes mellitus in China: a propensity score-matched analysis
Authors: He Chenlu , Wang Wei , Chen Qian , Shen Ziyuan , Pan Enchun , Sun Zhongming , Lou Peian , Zhang Xunbao
Published: March 2022

Objective:

This study aimed to examine the impact of different dietary patterns on stroke outcomes among type 2 diabetes mellitus (T2DM) patients in China.

Design:

Participants were enrolled by a stratified random cluster sampling method in the study. After collecting dietary data using a quantified FFQ, latent class analysis was used to identify dietary patterns, and propensity score matching was used to reduce confounding effects between different dietary patterns. Binary logistic regression and conditional logistic regression were used to analyse the relationship between dietary patterns and stroke in patients with T2DM.

Setting:

A cross-sectional survey available from December 2013 to January 2014.

Participants:

A total of 13 731 Chinese residents aged 18 years or over.

Results:

Two dietary patterns were identified: 61·2 % of T2DM patients were categorised in the high-fat dietary pattern while 38·8 % of patients were characterised by the balanced dietary pattern. Compared with the high-fat dietary pattern, the balanced dietary pattern was associated with reduced stroke risk (OR = 0·63, 95 %CI 0·52, 0·76,P< 0·001) after adjusting for confounding factors. The protective effect of the balanced model did not differ significantly (interactionP> 0·05).

Conclusions:

This study provides sufficient evidence to support the dietary intervention strategies to prevent stroke effectively. Maintaining a balanced dietary pattern, especially with moderate consumption of foods rich in quality protein and fresh vegetables in T2DM patients, might decrease the risk of stroke in China.
Healthy and unhealthy eating after a behaviour change intervention in primary care
Authors: Samdal Gro Beate , Furset Ole Johan , Nysæther Marte Blom , Abildsnes Eirik , Mildestvedt Thomas , Meland Eivind
Published: March 2022

Background:

To prevent and reduce non-communicable diseases, the Norwegian Directorate of Health encourages Healthy Life Centres (HLCs) in all municipalities.

Aims:

This study investigates whether the behaviour change interventions at HLCs positively affected participants’ diet and to evaluate predictors for healthy and unhealthy eating. Our data are part of the Norwegian Healthy Life Centre Study, a 6-month, pragmatic randomised controlled trial (RCT).

Methods:

Totally, 118 participants ≥18 years old were randomised to an intervention group (n 57), or a waiting list (control group) (n 61). Eighty-six participants met at the 6 months follow-up visit. We merged the participants to one cohort for predictor analyses, using linear regressions.

Findings:

The RCT of the HLCs’ interventions had no effect on healthy and unhealthy eating 6 months after baseline compared with controls. A short, additional healthy eating education programme produced a modest, statistically significant improvement in healthy eating compared with controls. This did not, however, reduce unhealthy eating. Higher income predicted unhealthier eating over time. Increasing body mass index and impaired physical functioning also led to an increase in unhealthy eating. Healthy eating at 6 months was predicted by self-rated health (SRH), vitality and life satisfaction, and hampered by musculo-skeletal challenges and impaired self-esteem (SE). SRH impacted improvement in healthy eating during the 6 months. The effect of interventions on healthier eating may be improved by an emphasis on developing positive self-concepts like better SRH, vitality, life satisfaction, and SE.
Counterfactuals and Contingency in WTO Dispute Settlement History
Authors: Pelc Krzysztof
Published: March 2022

With the benefit of hindsight, much scholarship across political science, law, and economics has told the story of the international trade regime as if it had been pulled all along by a definite aim. By contrast, this article emphasizes the contingent aspects of the trade regime's development, looking especially to its dispute settlement mechanism. The very creation of the Appellate Body had by no means a certain outcome, and once created, the tribunal's evolution was largely unanticipated by states. An often-overlooked actor played a key role in that development: the WTO Secretariat. Drawing on recent findings, this article lays out the full extent of the Secretariat's role in dispute settlement, which remains largely hidden from view, and deliberately so. From appointing adjudicators and managing their remuneration, to providing them with legal arguments and drafting final rulings, the Secretariat of the WTO looms larger than in any comparable tribunal. Making its influence more transparent, I argue, would go a long way to returning the system to the shape it was designed to have at its outset.
Theory Development and Evaluation Within a Critical Media Effects	Framework
Authors: Riles Julius Matthew , Ramasubramanian Srividya , Behm-Morawitz Elizabeth
Published: March 2022

Abstract. Investigating the role of identity in mediated experiences involves a great deal of complexity. However, media psychologists all too often explore the antecedents and consequences of identity in ways that less than optimally grapple with this complexity. In this essay, we build on the critical media effects (CME) approach to offer innovative ways to theorize about intersectionality within media psychology scholarship. We apply and elaborate on an intersectional approach to identity within media psychology to advance our understanding of media experiences within three key areas: media selectivity, media use, and media effects. We provide recommendations and salient examples for using critical media effects theorizing to examine intersectionality and better realize the complex dynamism of social identity.
Rethinking Sea‐Level Projections Using Families and Timing Differences
Authors: Slangen A. B. A. , Haasnoot M. , Winter G.
Published: March 2022

In the recent decade, many global and regional sea‐level rise (SLR) projections have been published, which raises questions for users. Here, we present a series of strategies to help users to see the forest for the trees, by reducing the number of choices to be made. First, we use the similarities in the methodologies and contributing sources of the projections to group 82 projections from 29 publications into only 8 families. Second, we focus on the timing of reaching several global mean SLR thresholds, and the uncertainty therein, rather than the projected value in the year 2100. Finally, we combine the information on timing and families to define three categories which can support decision making. For global mean SLR up to 0.50 m the differences in timing are small, regardless of climate scenario or family, clearly indicating a timing window for adaptation decisions. For larger global mean SLR (0.75–1.00 m), the climate scenario becomes more important for the uncertainties in timing, but the SLR threshold will be crossed within a limited window of time, supporting adaptation decision making on the medium to long term. Beyond 1.00 m the differences between the families and climate scenario strongly determine the uncertainties in timing, and more information is needed, for instance using early warning signals, before decisions for adaptation can be made. We make recommendations on how each of these three categories, combined with the lead time and lifespan of adaptation options, can inform decisions on adaptation strategies using adaptation pathways planning.
Numerical Investigation of Sediment‐Yield Underestimation in Supply‐Limited Mountain Basins With Short Records
Authors: Hirschberg Jacob , McArdell Brian W. , Bennett Georgina L. , Molnar Peter
Published: March 2022

Climate and sediment supply are critical for geomorphic systems. It is known that complex relations between such forcings and sediment mobilization may lead to dampened or erased environmental signals in sediment records. But it is unclear under which circumstances environmental signals are transmitted and measurable downstream. We used a numerical approach consisting of a sediment cascade model and a stochastic weather generator to quantify climate forcing effects under a range of sediment supply regimes in a debris‐flow catchment in the Swiss Alps (Illgraben). We show that sediment yields estimated from short records are highly uncertain both in terms of mean and interannual variability. Furthermore, sediment yields tend to be underestimated in supply‐limited systems, where also long‐term memory effects, driven by the history of sediment storage, are evident. Consequently, determining geomorphic system response from short records may be grossly inaccurate and should be extended with sediment supply detection and uncertainty analysis.
Implications of Multiple Corona Bursts in Lightning Processes for Radio Frequency Interferometer Observations
Authors: Liu Ningyu , Scholten Olaf , Dwyer Joseph R. , Hare Brian M. , Sterpka Christopher F. , Tilles Julia N. , Lind Frank D.
Published: March 2022

Recent observations from LOFAR indicate that multiple, spatially distributed corona bursts can occur in lightning processes with a timescale of 10 microseconds. The close proximity of the corona bursts in space and time poses a great observation challenge for short‐baseline (typically ≤100 m) radio interferometers. This paper reports simulations to show the interferometry results that would be obtained with such an interferometer. In particular, spatially‐separated corona bursts at fixed locations may be seen as a fast (>107 m/s) propagating source with large power variation if the resolution of the instrument is greater than the spatial separation of the bursts. The implications and suggestions for lightning interferometry studies are discussed in the paper.
Using InSAR Data to Improve the Water Vapor Distribution Downstream of the Core of the South American Low‐Level Jet
Authors: Mateus P. , Miranda P. M. A.
Published: March 2022

Two and half years of Interferometric Synthetic Aperture Radar (InSAR) images obtained by Sentinel‐1 near Santa Cruz de la Sierra, Bolivia, before August 2019 are here analyzed and assimilated in the Weather Research and Forecast model (WRF) to assess the quality of the water vapor field at the core of the South American Low‐level Jet, and the downstream propagation of the implied water vapor anomalies into a large sector of South America. Due to the topographic locking of the Jet near the edge of the Andes cordillera at Santa Cruz, this experiment allows an assessment of the extension of the spatial impact of InSAR data assimilation in varying circulation conditions. That data improves the model skill at varying locations thousands of kilometers downstream, in both the distribution of water vapor assessed at a large number of well‐distributed GNSS observations and precipitation assessed against the Global Precipitation dataset and ERA5 reanalysis. Gains in the precipitation forecast skill are found to have a larger impact on the forecast of light rain, and lead to an almost cancellation of forecasts of no rain in cases with moderate to heavy rain. Because the distribution of water vapor is a main driver of weather, and InSAR is one of the few sources of data that can look down to mesoscale resolution regardless of daytime or weather, it is suggested that it may have a significant positive impact on short‐range weather forecasting and, maybe more importantly, on the quality of the climate of the forecast model.
Mutant p53: it’s not all one and the same
Authors: Kennedy Margaret C. , Lowe Scott W.
Published: March 2022

Mutation of the TP53 tumor suppressor gene is the most common genetic alteration in cancer, and almost 1000 alleles have been identified in human tumors. While virtually all TP53 mutations are thought to compromise wild type p53 activity, the prevalence and recurrence of missense TP53 alleles has motivated countless research studies aimed at understanding the function of the resulting mutant p53 protein. The data from these studies support three distinct, but perhaps not necessarily mutually exclusive, mechanisms for how different p53 mutants impact cancer: first, they lose the ability to execute wild type p53 functions to varying degrees; second, they act as a dominant negative (DN) inhibitor of wild type p53 tumor-suppressive programs; and third, they may gain oncogenic functions that go beyond mere p53 inactivation. Of these possibilities, the gain of function (GOF) hypothesis is the most controversial, in part due to the dizzying array of biological functions that have been attributed to different mutant p53 proteins. Herein we discuss the current state of understanding of TP53 allele variation in cancer and recent reports that both support and challenge the p53 GOF model. In these studies and others, researchers are turning to more systematic approaches to profile TP53 mutations, which may ultimately determine once and for all how different TP53 mutations act as cancer drivers and whether tumors harboring distinct mutations are phenotypically unique. From a clinical perspective, such information could lead to new therapeutic approaches targeting the effects of different TP53 alleles and/or better sub-stratification of patients harboring TP53 mutant cancers.
Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary
Authors: Kemenesi Gábor , Tóth Gábor E. , Mayora-Neto Martin , Scott Simon , Temperton Nigel , Wright Edward , Mühlberger Elke , Hume Adam J. , Suder Ellen L. , Zana Brigitta , Boldogh Sándor A. , Görföl Tamás , Estók Péter , Szentiványi Tamara , Lanszki Zsófia , Somogyi Balázs A. , Nagy Ágnes , Pereszlényi Csaba I. , Dudás Gábor , Földes Fanni , Kurucz Kornélia , Madai Mónika , Zeghbib Safia , Maes Piet , Vanmechelen Bert , Jakab Ferenc
Published: March 2022

Some filoviruses can be transmitted to humans by zoonotic spillover events from their natural host and filovirus outbreaks have occured with increasing frequency in the last years. The filovirus Lloviu virus (LLOV), was identified in 2002 in Schreiber’s bats (Miniopterus schreibersii) in Spain and was subsequently detected in bats in Hungary. Here we isolate infectious LLOV from the blood of a live sampled Schreiber’s bat in Hungary. The isolate is subsequently sequenced and cultured in the Miniopterus sp. kidney cell line SuBK12-08. It is furthermore able to infect monkey and human cells, suggesting that LLOV might have spillover potential. A multi-year surveillance of LLOV in bats in Hungary detects LLOV RNA in both deceased and live animals as well as in coupled ectoparasites from the families Nycteribiidae and Ixodidae. This correlates with LLOV seropositivity in sampled Schreiber’s bats. Our data support the role of bats, specifically Miniopterus schreibersii as hosts for LLOV in Europe. We suggest that bat-associated parasites might play a role in the natural ecology of filoviruses in temperate climate regions compared to filoviruses in the tropics.
Stress distribution and surface shock wave of drop impact
Authors: Sun Ting-Pi , Álvarez-Novoa Franco , Andrade Klebbert , Gutiérrez Pablo , Gordillo Leonardo , Cheng Xiang
Published: March 2022

Drop impact causes severe surface erosion, dictating many important natural, environmental and engineering processes and calling for substantial prevention and preservation efforts. Nevertheless, despite extensive studies on the kinematic features of impacting drops over the last two decades, the dynamic process that leads to the drop-impact erosion is still far from clear. Here, we develop a method of high-speed stress microscopy, which measures the key dynamic properties of drop impact responsible for erosion, i.e., the shear stress and pressure distributions of impacting drops, with unprecedented spatiotemporal resolutions. Our experiments reveal the fast propagation of self-similar noncentral stress maxima underneath impacting drops and quantify the shear force on impacted substrates. Moreover, we examine the deformation of elastic substrates under impact and uncover impact-induced surface shock waves. Our study opens the door for quantitative measurements of the impact stress of liquid drops and sheds light on the origin of low-speed drop-impact erosion.
Biomimetic KcsA channels with ultra-selective K+ transport for monovalent ion sieving
Authors: Xin Weiwen , Fu Jingru , Qian Yongchao , Fu Lin , Kong Xiang-Yu , Ben Teng , Jiang Lei , Wen Liping
Published: March 2022

Ultra-selective and fast transport of K+ are of significance for water desalination, energy conversion, and separation processes, but current bottleneck of achieving high-efficiency and exquisite transport is attributed to the competition from ions of similar dimensions and same valence through nanochannel communities. Here, inspired by biological KcsA channels, we report biomimetic charged porous subnanometer cages that enable ultra-selective K+ transport. For nanometer to subnanometer scales, conically structured double-helix columns exhibit typical asymmetric transport behaviors and conduct rapid K+ with a transport rate of 94.4 mmol m−2 h−1, resulting in the K+/Li+ and K+/Na+ selectivity ratios of 363 and 31, respectively. Experiments and simulations indicate that these results stem from the synergistic effects of cation-π and electrostatic interactions, which impose a higher energy barrier for Li+ and Na+ and lead to selective K+ transport. Our findings provide an effective methodology for creating in vitro biomimetic devices with high-performance K+ ion sieving.
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
Authors: Xiong Wenjun , Gao Xueliang , Zhang Tiantian , Jiang Baishan , Hu Ming-Ming , Bu Xia , Gao Yang , Zhang Lin-Zhou , Xiao Bo-Lin , He Chuan , Sun Yishuang , Li Haiou , Shi Jie , Xiao Xiangling , Xiang Bolin , Xie Conghua , Chen Gang , Zhang Haojian , Wei Wenyi , Freeman Gordon J. , Shu Hong-Bing , Wang Haizhen , Zhang Jinfang
Published: March 2022

Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibiting the deubiquitinase, USP8, significantly enhances the efficacy of anti-PD-1/PD-L1 immunotherapy through reshaping an inflamed tumor microenvironment (TME). Mechanistically, USP8 inhibition increases PD-L1 protein abundance through elevating the TRAF6-mediated K63-linked ubiquitination of PD-L1 to antagonize K48-linked ubiquitination and degradation of PD-L1. In addition, USP8 inhibition also triggers innate immune response and MHC-I expression largely through activating the NF-κB signaling. Based on these mechanisms, USP8 inhibitor combination with PD-1/PD-L1 blockade significantly activates the infiltrated CD8+T cells to suppress tumor growth and improves the survival benefit in several murine tumor models. Thus, our study reveals a potential combined therapeutic strategy to utilize a USP8 inhibitor and PD-1/PD-L1 blockade for enhancing anti-tumor efficacy.
Heterogeneous relational message passing networks for molecular dynamics simulations
Authors: Wang Zun , Wang Chong , Zhao Sibo , Xu Yong , Hao Shaogang , Hsieh Chang Yu , Gu Bing-Lin , Duan Wenhui
Published: March 2022

With many frameworks based on message passing neural networks proposed to predict molecular and bulk properties, machine learning methods have tremendously shifted the paradigms of computational sciences underpinning physics, material science, chemistry, and biology. While existing machine learning models have yielded superior performances in many occasions, most of them model and process molecular systems in terms of homogeneous graph, which severely limits the expressive power for representing diverse interactions. In practice, graph data with multiple node and edge types is ubiquitous and more appropriate for molecular systems. Thus, we propose the heterogeneous relational message passing network (HermNet), an end-to-end heterogeneous graph neural networks, to efficiently express multiple interactions in a single model with ab initio accuracy. HermNet performs impressively against many top-performing models on both molecular and extended systems. Specifically, HermNet outperforms other tested models in nearly 75%, 83% and 69% of tasks on revised Molecular Dynamics 17 (rMD17), Quantum Machines 9 (QM9) and extended systems datasets, respectively. In addition, molecular dynamics simulations and material property calculations are performed with HermNet to demonstrate its performance. Finally, we elucidate how the design of HermNet is compatible with quantum mechanics from the perspective of the density functional theory. Besides, HermNet is a universal framework, whose sub-networks could be replaced by other advanced models.
Bioartificial pulsatile cuffs fabricated from human induced pluripotent stem cell-derived cardiomyocytes using a pre-vascularization technique
Authors: Endo Yuki , Homma Jun , Sekine Hidekazu , Matsuura Katsuhisa , Shimizu Tatsuya , Niinami Hiroshi
Published: March 2022

There is great interest in the development of techniques to bioengineer pulsatile myocardial tissue as a next-generation regenerative therapy for severe heart failure. However, creation of thick myocardial grafts for regenerative medicine requires the incorporation of blood vessels. In this study, we describe a new method of constructing a vascular network in vivo that allows the construction of thick human myocardial tissue from multi-layered cell sheets. A gelatin sheet pre-loaded with growth factors was transplanted onto the superficial femoral artery and vein of the rat. These structures were encapsulated together within an ethylene vinyl alcohol membrane and incubated in vivo for 3 weeks (with distal superficial femoral artery ligation after 2 weeks to promote blood flow to the vascular bed). Subsequently, six cardiomyocyte sheets were transplanted onto the vascular bed in two stages (three sheets, two times). Incubation of this construct for a further week generated vascularized human myocardial tissue with an independent circulation supplied by an artery and vein suitable for anastomosis to host vessels. Notably, laminating six cell sheets on the vascular bed in two stages rather than one allowed the creation of thicker myocardial tissue while suppressing tissue remodeling and fibrosis. Finally, the pulsatile myocardial tissue was shown to generate auxiliary pressure when wrapped around the common iliac artery of a rat. Further development of this technique might facilitate the generation of circulatory assist devices for patients with heart failure.
Transcriptome-wide analysis of glioma stem cell specific m6A modifications in long-non-coding RNAs
Authors: Steponaitis Giedrius , Stakaitis Rytis , Valiulyte Indre , Krusnauskas Raulas , Dragunaite Rugile , Urbanavičiūtė Rūta , Tamasauskas Arimantas , Skiriute Daina
Published: March 2022

The interest in chemical RNA modifications is rapidly growing in the field of molecular biology. Dynamic and reversible alterations of N6-methyladenosine (m6A) RNA modification are responsible for a platter of structural and functional changes in healthy and cancerous cell states. Although many studies reported the link between tumor initiation/progression and m6A modulators, there are few studies exploring transcriptome-wide m6A profile of non-coding RNAs. The aim of current study was to identify glioma stem cell (GSC) specific m6A landscape of long non-coding RNAs (lncRNAs) applying MeRIP-seq approach. MeRIP-seq analysis assigned 77.9% of m6A peaks to mRNAs and 8.16% to lncRNAs. GSCs and differentiated cells showed 76.4% conservation of m6A peaks, while 19.4% were unique to GSCs. Seven novel GSC-specific m6A modified lncRNAs were identified: HRAT92, SLCO4A1-AS1, CEROX1, PVT1, AGAP2-AS1, MIAT, and novel lncRNA gene ENSG00000262223. Analysis disclosed a strong negative correlation between lncRNAs m6A modification rate and expression. MeRIP-seq analysis revealed m6A modifications on previously reported glioma-associated lncRNAs: LINC000461, HOTTIP, CRNDE, TUG1, and XIST. Moreover, current study disclosed that most highly m6A modified lncRNAs primarily contain m6A modifications close to 3′ and 5′ ends. Our results provide basis and insight for further studies of m6A modifications in non-coding transcriptome of GSCs.
Inflammatory cytokines and sarcopenia in Iranian adults-results from SARIR study
Authors: Asoudeh Farzaneh , Dashti Fatemeh , Raeesi Shima , Heshmat Ramin , Bidkhori Mohammad , Jalilian Zahra , Hashemi Rezvan
Published: March 2022

Some studies suggested the effects of inflammatory cytokines in reducing muscle mass and muscle strength and, performance. This study aimed to compare pro-inflammatory cytokines in sarcopenic and non-sarcopenic subjects. 120 men and women were selected out from the cross-sectional study ‘sarcopenia and its determinants among Iranian elders’ (SARIR). Sarcopenia was defined based on the first ‘European Working Group on sarcopenia in older people’ (EWGSOP1) guidelines. A fasting blood sample was taken from each participant to measure serum high-sensitivity C-reactive protein (hs-CRP), Interleukin 6 (IL-6), and tumor necrosis factor α (TNFα). A total of 120 participants were included in this study. Mean age was 66.7 ± 7.7 years and mean body mass index (BMI) was 27.3 ± 4.2 kg/m2. Forty participants had the criteria of EWGSOP1 sarcopenia. A statistically significant difference was seen between normal and abnormal groups of muscle strength in hs-CRP (P-value = 0.04). Furthermore, we did not observe any remarkable association between inflammatory biomarkers including IL-6 (OR 1.15; 95% CI 0.31–4.28), TNF-α (OR 0.68; 95% CI 0.17–2.77), and hs-CRP (OR 2.39; 95% CI 0.87–6.55) and the presence of sarcopenia even after controlling for plausible confounders. We found that inflammatory biomarkers level was not associated with odds of sarcopenia. The lack of correlation between inflammatory cytokines and sarcopenia could be due to the participants’ age and genetics. Future studies are required to confirm these findings.
Correlation between suicidal ideation and emotional memory in adolescents with depressive disorder
Authors: Hu Shuwen , Mo Daming , Guo Pengfei , Zheng Hongyu , Jiang Xiaolu , Zhong Hui
Published: March 2022

This study explored the differences in emotional memory between adolescents with and without suicidal ideation. Fifty adolescents with depression and suicidal ideation, 36 with depression but no suicidal ideation, and 41 healthy controls rated the emotional valence of positive, neutral, and negative pictures. Then, the recognition of the images was evaluated 72 h later. Adolescents with suicidal ideation reported more negative emotional valence scores for positive and neutral pictures and were significantly less likely to recognize negative pictures than were those without suicidal ideation. The performance of adolescents with suicidal ideation on the negative picture recognition test was closely related to anxiety, depression severity, and intensity of suicidal ideation. The negative bias toward neutral stimuli and cognitive impairment may be important risk factors for adolescents with suicidal ideation. Improving emotional memory via targeted management approaches may help young people with suicidal ideation.
How electrons Coulomb repulsion changes graphene band structure
Authors: Moradian Rostam , Rabibeigi Poorya
Published: March 2022

Base on effective medium theory we introduce a multi sites method for calculation of realistic energy bands of strongly correlated systems. We found due to approximated self energy, the density of states that obtained directly by calculated local Green function does not reflects system energy bands truly. By using this method we investigated how electrons repulsion renormalizes graphene bands. Graphene realistic bands calculated in both the dynamical mean field theory (DMFT) and four sites beyond super cell approximation for different repulsions. Our calculated interacting graphene bands illustrate a semi metal to a Mott insulator anti ferromagnetic phase transition at repulsions $$u = 2.2 t$$

u
=
2.2
t

and $$u = 0.6 t$$

u
=
0.6
t

for DMFT and four sites beyond super cell approximation respectively. These values are much less than finite size quantum Monte Carlo calculation prediction. We showed that the graphene bands are very sensitive to electrons repulsions and this phase transition happens at low repulsions in comparison to graphene band width.
Metal organic framework-based nanostructure materials: applications for non-lithium ion battery electrodes
Authors: Wang Jinghan , Kirlikovali Kent O. , Kim Soo Young , Kim Dong-Wan , Varma Rajender S. , Jang Ho Won , Farha Omar K. , Shokouhimehr Mohammadreza
Published: March 2022

Non-lithium ion (e.g., Al3+, Ca2+, K+, Mg2+, Na+, and Zn2+) batteries have emerged as a promising platform for next-generation energy storage systems.
Triplet–triplet annihilation photon upconversion from diphenylhexatriene and ring-substituted derivatives in solution
Authors: Mizokuro Toshiko , Kamada Kenji , Sonoda Yoriko
Published: March 2022

Diphenylhexatriene and its ring-substituted derivatives act as emitters and show blue-green to green upconverted emission under photoexcitation of 640 nm when mixed with a sensitiser molecule (a palladium complex) in solution in a nitrogen atmosphere.
Deep generative models for peptide design
Authors: Wan Fangping , Kontogiorgos-Heintz Daphne , de la Fuente-Nunez Cesar
Published: March 2022

We present a review of deep generative models and their applications in peptide design.
Tailoring the structure of polysulfone nanocomposite membranes by incorporating iron oxide doped aluminium oxide for excellent separation performance and antifouling property
Authors: Sherugar Prajwal , Déon S. , Nagaraja K. K. , Padaki Mahesh
Published: March 2022

Simple yet powerful strategy is developed for the fabrication of iron oxide doped aluminium oxide composite nanoparticles and investigated its role in membranes as novel nanoadditives for achieving excellent productivity and selectivity upto 120 h.
Development of a SAW poly(epichlorohydrin) gas sensor for detection of harmful chemicals
Authors: Pan Yong , Wang Puhong , Zhang Genwei , Yan Cancan , Zhang Lin , Guo Tengxiao , Wang Wen , Zhai Shoupei
Published: March 2022

The uniformity and compactness of a viscoelastic film are among the most important factors that influence the characteristics of a surface acoustic wave (SAW) gas sensor, directly affecting the detection sensitivity of a SAW sensor on a target gas.
Anionic stitching polymerization of styryl(vinyl)silanes for the synthesis of sila-cyclic olefin polymers
Authors: Ikeda Sho , Shintani Ryo
Published: March 2022

Anionic stitching polymerization of styryl(vinyl)silanes was developed for synthesizing new polymers possessing fused sila-bicyclic structures in the main chain.
Single atom alloys vs. phase separated alloys in Cu, Ag, and Au atoms with Ni(111) and Ni, Pd, and Pt atoms with Cu(111): a theoretical exploration
Authors: Yin Junqing , Ehara Masahiro , Sakaki Shigeyoshi
Published: March 2022

Combination of 3d metal host and 5d metal guest tends to form single-atom alloy. That of 3d metal host and 3d metal guest tends to form phase-separated alloy. The 4d metal guest exhibits intermediate behavior between 3d and 5d metal guests.
Pressure-induced evolution of structures and promising superconductivity of ScB6
Authors: Du Junyi , Li Xiaofeng , Peng Feng
Published: March 2022

Three new high-pressure phases of ScB6 are explored with excellent superhard and electronic properties.
Multi-modal characterization of kesterite thin-film solar cells: experimental results and numerical interpretation
Authors: Saadaldin Abdellatif , Slyamov Azat M. , Stuckelberger Michael E. , Jørgensen Peter S. , Rein Christian , Lucas Mariana Mar , Ramos Tiago , Rodriguez-Fernandez Angel , Bernard Dominique , Andreasen Jens W.
Published: March 2022

Scanning X-ray microscopy is shown to be powerful for in situ and operando studies of nanostructured devices such as CZTS solar-cells: nanoscale performance is correlated with composition, and observed trends are understood with simulations.
Sustainable and fast synthesis of functionalized quinoxalines promoted by natural deep eutectic solvents (NADESs)
Authors: Lupidi Gabriele , Palmieri Alessandro , Petrini Marino
Published: March 2022

A NADES, choline chloride/water, allows a high yielding preparation of pure quinoxalines embedding acid sensitive and other functional groups at room temperature in a very short reaction time.
Inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) for the analysis of fuels, biofuels and their feedstock using a high temperature total consumption sample introduction system operated under continuous sample aspiration mode
Authors: Martínez Santiago , Sánchez Raquel , Todolí José-Luis
Published: March 2022

Light petroleum cuts, diesel oil, kerosene, pyrolysis oils, vegetal oils and grease have been analyzed in continuous mode through the high temperature torch integrated sample introduction system hTISIS-ICP-MS/MS.
Hydrophobic nanofibers: a peptide-based functional anti-fouling material
Authors: Hati Kshitish Chandra , Kumar Santosh , Mondal Sahabaj , Singh Surajit , Shit Ananda , Nandi Sujay Kumar , Haldar Debasish
Published: March 2022

Peptides with phenylalanine formed supramolecular hydrophobic sheet-like structures and nanofibrils and the resultant surfaces show anti-sticking effects against water and inhibit the growth ofE. coli.
Circular RNA profiles of osteoarthritic synovium
Authors: Liu Pengjuan , Gao Ge , Zhou Xiao , Zhang Xiao , Cai Qiaoling , Xiang Zhongyuan , Shen Xiongjie , Wu Xiang
Published: March 2022

Circular RNA expression profiling and experimental validation revealed that hsa_circ_0072697 was highly expressed in the synovium of OA patients and it might be a sponge of hsa-miR-6736-5p, which could lead to increased LEP and ULK1 mRNA expression.
Differential copper-guided architectures of amyloid β peptidomimetics modulate oxidation states and catalysis
Authors: Ghosh Debasis , Konar Mouli , Mondal Tanmay , Govindaraju Thimmaiah
Published: March 2022

The fibrillar assembly of AkdNMCPy peptidomimetics with cyclic dipeptide and pyrene units was engineered into Cu-guided differential architectures that stabilize CuIIand CuIstates and exhibit distinct catalytic activities.
Development of a carbon dot and methylene blue NIR-emitting FLIM-FRET pair in niosomes for controlled ROS generation
Authors: Chatterjee Arunavo , Sharma Ankit Kumar , Purkayastha Pradipta
Published: March 2022

Yellow-emitting carbon dots can do FRET with methylene blue in niosomes to generate ROS in a controlled way.
Correction: D–π–A type conjugated indandione derivatives: ultrafast broadband nonlinear absorption responses and transient dynamics
Authors: Chen Lu , Wu Xingzhi , Li Zhongguo , Niu Ruipeng , Zhou Wenfa , Liu Kun , Sun Yingfei , Shao Zhangyang , Yang Junyi , Song Yinglin
Published: March 2022

Correction for ‘D–π–A type conjugated indandione derivatives: ultrafast broadband nonlinear absorption responses and transient dynamics’ by Lu Chen et al., RSC Adv., 2022, 12, 8624–8631, DOI: 10.1039/D2RA00349J.
Correction: Large-scale synthesis of ultrafine Fe3C nanoparticles embedded in mesoporous carbon nanosheets for high-rate lithium storage
Authors: Yu Ying , Wang Xuanli , Zhang Hongkun , Cao Zhiqin , Wu Haoyang , Jia Baorui , Yang Jun Jun , Qu Xuanhui , Qin Mingli
Published: March 2022

Correction for ‘Large-scale synthesis of ultrafine Fe3C nanoparticles embedded in mesoporous carbon nanosheets for high-rate lithium storage’ by Ying Yu et al., RSC Adv., 2022, 12, 6508–6514, DOI: 10.1039/d1ra08516f.
Fuel-driven macromolecular coacervation in complex coacervate core micelles
Authors: Lewis Reece W. , Klemm Benjamin , Macchione Mariano , Eelkema Rienk
Published: March 2022

We apply an allyl acetate fuelled chemical reaction network (CRN) to control the coacervation of macromolecular species at constant physiological pH without the need for complex biomolecules.
Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy
Authors: Kao Wei-Chun , Hunte Carola
Published: March 2022

Cytochrome (cyt) bc1, bcc and b6f complexes, collectively referred to as cyt bc complexes, are homologous isoprenoid quinol oxidising enzymes present in diverse phylogenetic lineages. Cyt bc1 and bcc complexes are constituents of the electron transport chain (ETC) of cellular respiration, and cyt b6f complex is a component of the photosynthetic ETC. Cyt bc complexes share in general the same Mitchellian Q cycle mechanism, with which they accomplish proton translocation and thus contribute to the generation of proton motive force which drives ATP synthesis. They therefore require a quinol oxidation (Qo) and a quinone reduction (Qi) site. Yet, cyt bc complexes evolved to adapt to specific electrochemical properties of different quinone species and exhibit structural diversity. This review summarises structural information on native quinones and quinone-like inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Qi site architecture of cyt bc1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Qi sites in very similar distance to haem bH. In contrast, more diverse positions of native quinone molecules were resolved at Qo sites, suggesting multiple quinone binding positions or captured snapshots of trajectories toward the catalytic site. A wide spectrum of inhibitors resolved at Qo or Qi site covers fungicides, antimalarial and antituberculosis medications and drug candidates. The impact of these structures for characterising the Q cycle mechanism, as well as their relevance for the development of medications and agrochemicals are discussed.
Neighborhood‐based distributed robust unknown input observer for fault estimation in nonlinear networked systems
Authors: Rahimi Farshad , Ahmadpour Shirin
Published: March 2022

In this paper, a robust distributed fault estimation is addressed for a class of nonlinear networked systems with actuator faults where influences from process disturbances are minimized. In real‐time monitoring systems, a substantial challenge is to find out the size and the shape of the occurred faults, and consequently, it is significantly more difficult in multi‐agent systems. To consider this concern, in this paper, a distributed fault estimation approach has been proposed for multi‐agent systems such that each agent employs an augmented system owing to a designated communication graph for estimating the fault and states both in this agent and in its neighbors. Meanwhile, each agent is equipped with an unknown input observer (UIO) to decouple the partial disturbances of the process as much as possible and to reduce the disturbances that cannot be decoupled. In the form of linear matrix inequalities (LMIs), sufficient conditions are provided to guarantee stability and to obtain the parameter matrices of the introduced observer. Finally, two numerical examples are provided to verify the performance of the introduced fault estimation scheme.