bluuebunny/crossref_metadata_2025 huggingface dataset:
A General Understanding in Alzheimer's Disease
Authors: Zhang Liuduoduo
Published: January 2024

Alzheimer’s Disease (AD) normally happens in people with age of 65 or above, and it is the most common cause of dementia. It suggests that the total cost of dementia worldwide will reach US $2 trillion by 2030 or even more, due to more people being aware of it these years and having the ability to take a diagnosis and treatment. This review about AD is mainly focused on neuropathology, symptoms, risk factors, current treatments including traditional pharmacological therapies and newly developed disease modifying therapies (DMTs) of AD. Although the cause of AD has not been fully discovered, it is sure that AD is proved with pathology of the accumulation of 2 aggregates appearing in the brain, which are extracellular Aβ plaques and intracellular neurofibrillary tau-containing tangles. DMTs are known to be treatments that have an effect on the pathology of AD. Currently the two approved DMTs (Aducanumab and Lecanemab) are both Aβ-directed monoclonal antibodies, but there are tau-directed therapy trials going on. Although DMTs are only used at an early stage of AD progression and have been only approved very recently, they have less side effects and have more benefits compared with traditional drugs used to relieve decline in cognitive symptoms without altering the pathology of AD.
Why Dementia is Associated with Poor Morbidity and Novel Treatments: An In-Depth Discussion about Alzheimer’s Disease
Authors: Zhang Tianyao
Published: January 2024

One of the most common forms of dementia around the world is Alzheimer’s. By 2022, it is estimated one out of every three seniors diagnosed with Alzheimer’s will eventually die due to complications from the disease [1]. There are several biological and physical markers of Alzheimer’s that may indicate that one has the disease, with symptoms all relating to a decline in cognitive function. The general development of Alzheimer’s is ascribed to two factors, genetic and environmental. Along with the growth of an aging population and the absence of a definitive cure, the search for novel treatments has gained significant momentum. Some promising treatments include: immunotherapies targeting amyloid-beta plaques, such as the monoclonal antibody ‘donanemab’; precision medicine for personalized therapies, namely deep brain stimulation (DBS); and TRIM11 as a biological target for the slowing of the decline in cognitive abilities. Despite progression in the development of novel treatments, the pathophysiological mechanism of the disease is yet to be understood, accounting for various trial-and-error type experiments. Continued research and a comprehensive approach are vital for the development of effective therapies for Alzheimer’s disease.
Preface: 2023 International Conference on Architecture, Civil Engineering and Geotechnical Engineering (ACEGE 2023)
Authors: Edith Mirabelle , Tian Shuang
Published: January 2024

The 2023 International Conference on Architecture, Civil Engineering and Geotechnical Engineering (ACEGE 2023) was successfully held from 11 to 12 November, 2023 in Atlanta, USA. This event has the objective of creating an international forum for academics, researchers, and scientists from worldwide to discuss results and proposals regarding to the soundest issues related to architecture design, construction technology, civil engineering, structural engineering, and geotechnical engineering.

We are confident that ACEGE 2023 will play an important role in encouraging activities in research and development of architecture, civil engineering and geotechnical engineering, and give excellent opportunities for collaboration between research institutions. The broad scope of this event provides a unique meeting ground for researchers spanning the whole spectrum of our discipline. We hope from over the day, some fruitful collaboration can be established.

ACEGE Organizing Committee

Atlanta, USA
The Protective Effect of the COVID-19 Vaccine in Cancer Patients
Authors: Jia Ruoyu
Published: January 2024

The novel coronavirus pneumonia pandemic has led to bad engulf on public health worldwide. Widespread vaccination with SARS-CoV-2 vaccine (COVID-19 vaccine) has become one of the most potentially effective strategy of ending the epidemic and avoiding the public suffering from both physical and psychological pain. With weak autoimmunity and the complex body condition in different stages of treatment, cancer patients are more vulnerable and sensitive to infect in COVOD-19 pandemics. There are many data indicating that cancer patients usually obtain the higher mobidity, higher rate of the severe illness and higher fatality in COVID-19 pandemic. In that case, they are in greater need of protective measures, of which vaccination is the most convenient and widely accepted protective. Based on the existing clinical studies, this review aims to focus on the safety and efficacy of the COVID-19 vaccine in patients with cancer. After that the immunogenicity of the vaccine itself, adjuvant, doses, times of vaccinations and patient condition are listed to consider how they affet the effect of vaccine. Due to the complexity of the immune function of cancer patients, COVID-19 vaccination in cancer patients is extremely critical to protect from COVID-19 pneumonia, so large-scale clinical studies and real-world research data are still needed to develop a more refined and appropriate vaccination program to achieve better protection of oncology patients.
Lateral Ankle Sprain: Epidemiology, Prevention, Treatment, and Group-specified Guidelines
Authors: Jin Xueyue
Published: January 2024

Lateral ankle sprains are a prevalent and diverse injury, but unfortunately, in previous studies, there are few clear guidelines for categorized patient groups to face it. So, this article aims to present a comprehensive guide for specific patient groups to make right the decisions when facing the problem of lateral ankle sprain by comparing and analyzing epidemiology, prevention, and treatment strategies of lateral ankle sprain. Risking factors are revealed in Epidemiological studies. The advantages and disadvantages of prevention strategies including taping & bracing, shoe design, and exercise programs are discussed. And surgical and conservative treatments are compared. For suggestions, athletes should apply a balanced approach involving taping, bracing, exercise programs, and surgical options. Non-athlete individuals engaging in sports activities should make their prevention and treatment choices based on their functional demands. Those less sport-inclined can employ few preventions and choose more conservative treatments.
The Role of Technology in Epidemic Management of Covid-19
Authors: Guo Muyi , Liu Yuqi , Luo Zhijia , Zhou Mo
Published: January 2024

The worldwide repercussions of the Covid-19 pandemic have compelled nations to seek innovative solutions. Concurrently, the evolution of technology has unveiled a host of emerging solutions that hold the potential to revolutionize infectious disease management. This study offers a comprehensive overview of pandemic control, encompassing prevention, contact tracing, detection, and treatment. Particularly in the context of the Covid-19 era, the paper retrospectively evaluates technological applications in these domains. Synthesizing insights, it provides a nuanced understanding of technology's interplay with disease management. Drawing from the collective wisdom of the Covid-19 epoch, this study informs the development of effective measures intertwined with technological advancements. Furthermore, the paper forecasts and recommends paths for technology-driven infectious disease management, establishing a basis for informed decisions amid global challenges.
Stili di alimentazione religiosamente orientati e sostenibilità nell’esperienza giuridica dei territori prospicienti il Mar Mediterraneo
Authors: Freni Fortunato
Published: January 2024

Religiously oriented eating styles and sustainability in the legal experience of the territories facing the Mediterranean Sea 

ABSTRACT: The paper presents the different eating styles created by religious confessions, which were born in the territories facing the Mediterranean Sea, and by oriental religions, which have also taken root in Europe. Some problems that arise in the exercise of religious food freedom within civil legal systems are analyzed. The interrelationships between political institutions, religious confessions and communities ethically committed to sustainable development are studied, in order to use the different food codes to more effectively pursue the unitary objective of improving the health and well-being of living beings in the Euro-Mediterranean area, of wisely exploit environmental resources and redistribute food more equitably.

SOMMARIO: 1. Il cibo nei territori prospicienti il Mar Mediterraneo tra pluralismo etnico-religioso e biodiversità - 2. I diversi codici alimentari delle religioni mediterranee - 3. I rapporti fra ordinamenti civili e religiosi in ordine alla libertà religiosa alimentare - 4. Diritto al cibo, diritto dell’ambiente ed ecologia integrale fra sistemi giuridici religiosi e umanesimi non confessionali - 5. I novel food e i tentativi di greenwashing - 6. La sostenibilità del cibo per “alimentare” il laico sogno europeo di unità nella diversità.
(auto)sovversione del diritto
Authors: Loddo Olimpia Giuliana
Published: January 2024

La pubblicazione del libro La (auto)sovversione del diritto: ambiguità e paradossi del sistema immunitario della società di Gunther Teubner e Riccardo Prandini fornisce un’importante opportunità di riflessione sull’(auto)sovversione del diritto. Da tale riflessione emergono cinque fondamentali prospettive di analisi: (i) l’(auto)sovversione come espressione del “sistema immunitario” nella teoria dei sistemi sociali; (ii) la dimensione istituzionale degli effetti orizzontali dei diritti fondamentali; (iii) il contrasto tra plusvalore monetario e plusvalori non-monetari; (iv) il costituzionalismo societario quale possibile cornice teorica per chiarire il fenomeno dell’(auto)sovversione; (v) il ruolo della dialettica tra diritto e giustizia nell’(auto)sovversione del diritto. Questa nota critica fornisce una panoramica delle tematiche e delle complessità che caratterizzano il concetto di (auto)sovversione, enfatizzando la distinzione tra (auto)sovversione endogena e (auto)sovversione esogena. La prima, l’(auto)sovversione endogena, si riferisce alle dinamiche interne al sistema giuridico che minacciano la sua coerenza o la sua capacità di raggiungere gli obiettivi. La seconda, l’(auto)sovversione esogena si riferisce a fattori esterni al sistema giuridico che contrastano, trasformano o sfidano le istituzioni giuridiche.
The Livable and the Unlivable
Authors: Butler Judith , Worms Frédéric
Published: January 2024

The unlivable is the most extreme point of human suffering and injustice. But what is it exactly? How do we define the unlivable? And what can we do to prevent and repair it? These are the questions the authors of this book address in a dialogue situated at the crossroads of contemporary life and politics. Here, the book criticizes the norms that make life precarious and unlivable, while also appealing to a “critical vitalism” as a way of allowing the hardship of the unlivable to reveal what is vital for us. The difference between the livable and the unlivable forms the critical foundation for a contemporary practice of care. The dialogue transcribed and translated in this book took place at the Ecole Normale Superieure (ENS) on April 11, 2018, at a time when close to two thousand migrants were living in nearby makeshift camps in northern Paris. This dialogue is showcased in the context of the authors' ongoing work and the evolution of their thought, as presented by the book's introduction. The book concludes with a new afterword that addresses the crises unfolding in our world and the ways a philosophically rigorous account of life must confront them. In the conversation between the authors, we encounter questions we all grapple with in confronting the distress and precarity of our times, marked as it is by types of survival that are unlivable, from concentration camps to prisons to environmental toxicity, to forcible displacement, to the Covid pandemic. The book considers longstanding philosophical questions around why and how we live, while working to retrieve a philosophy of life for today's Left.
Translation from spoken Arabic digits to sign language based on deep learning approach
Authors: Almahmood Mothanna , Abualigah Sayel , Duwairi Rehab M. , Abualigah Laith , Zitar Raed Abu , Alsoud Anas Ratib , E. Sathishkumar V.
Published: January 2024

Deaf-and-dumb humans make up about 5% of the world's population, and they need special care by providing them alternative methods that help them to communicate with the outside world, whereas the sense of hearing is the main element of human communications, which is indispensable. From the standpoint of introducing helpful applications that help deaf-and-dumb population, the idea of this research aimed used deep learning techniques to create a model based on the principle of converting Arabic spoken digits to sign language images, through a study of two different datasets that were freely taken from open-source websites. The first one contains audio records of Arabic spoken digits that was used to train on-dimensional CNN model to generate a text translation of any Arabic spoken digit record. The second one contains sign language images of Arabic digits, where used to build IF-THEN rules system that can generate the sign language image as a translation of given Arabic digit text. The whole idea conducted through using both systems in one prediction model that can generate the sign language image of any giving spoken Arabic digits record, where it had accurate results with 86.85% accuracy value and 0.5039 loss value. The goal of this research is to add a new technology based on deep learning, in order to help this group of people with a simple idea that opens the researchers minds to produce a model of all Arabic spoken speech, which in turn can be a complete technology that helps deaf-and-dumb humans to easily communicate with the outside world.
RFID car using arduino mega 2560 by dijkstras algorithm
Authors: Sujay K. , Visweswar M.V.S. , Reddy B. Sai Teja , Hussain Md. Ali , Sakhamuri Sridevi , Abualigah Laith
Published: January 2024

This paper introduces a module which is used to transport goods or people from one place to another without any driver assistant. It is mainly used in big industries to save the time and energy. This module is built around an RFID sensor. RFID technology uses fields of electromagnetic waves to track and monitor tags attached to objects. When triggered with a field of electromagnetic waves investigate pulse from an adjacent RFID reader device, this tag delivers digital information back to the reader, which is often an inventory number. This number can be used to keep track of inventories. The sensors collect the data and sends to the main algorithm and then it takes the decision which way to go, we implemented our car to be completely automated and does not required any instructions from human. To achieve this we have chosen the shortest path algorithm know as Dijkstra's algorithm.
Developing an automated currency transactions forecasting process for global e-commerce and fintech companies
Authors: Paul Rudrendu Kumar
Published: January 2024

This paper introduces a groundbreaking automated forecasting process for global currency transactions, specifically designed for e-commerce and fintech companies. Traditional linear models, such as weekly moving averages, ARIMA, and SARIMA, have proven inadequate in capturing non-linearities and complex patterns within the data. To address these limitations, we propose an ensemble of diverse machine learning models. These models, characterized by varying lag periods, integrate regional holiday data, macroeconomic variables, and time-based variables. The proposed process exhibits high scalability, capable of simultaneously predicting forex currency transactions for multiple currencies. The implementation of this forecasting process empowers companies to manage currency exchange risk more effectively, enhance overall financial performance, and increase profits through consolidated transactions. Additionally, the automation of this process eliminates the need for manual forecasting, thereby boosting efficiency, accuracy, and employee morale. The findings of this study carry significant implications for the global e-commerce and fintech companies with operations in multiple currencies. They demonstrate the transformative potential of machine learning models in revolutionizing currency transaction forecasting and assisting in strategic decision-making for finance and treasury teams.
The application of Python game algorithm in Rouge games
Authors: Mi Zhewen , Zhang Zunyi
Published: January 2024

Our project's topic is algorithms for game design, which mainly describes a series of algorithms in the pygame library in Python, such as collisions, mazes, and a series of algorithms with different functions. The following is mainly about the ideas, processes, problems, and solutions encountered by our group's final project. In addition, we learned how to take part in the joint work and Python programming experience and the algorithms in pygame through this study and group cooperation.
The advantages and comparison of resistive touch screens and capacitive touch screens
Authors: Hu Ruijie
Published: January 2024

ATouch screens are an indispensable component in electronic products nowadays, and resistive and capacitive touch screens are the most common and widely used touch screens in touch screens. However, there is still a lack of intuitive literature to explain the differences and advantages between capacitive and resistive touch screens. This article provides a partial overview of the principles and structures of resistive and capacitive touch screen technologies and finally analyzes their respective advantages and disadvantages. The resistive touch screen is mainly divided into four-wire resistive touch screens and five-wire resistive touch screens. Its advantage over capacitive touch screens is that the process is more mature, and the product cost is lower. However, capacitive touch screens, due to their different working principles from resistive touch screens, can achieve multi-point touch, which is a significant feature. In capacitive touch screens, mutual capacitive projection capacitive touch screens have become the main favored technology in the touch screen industry due to their low power consumption, stable signal, and fast data collection speed. They are also an essential direction for the future development of touch screens.
A comparative study of flexible and rigid hand-oriented exoskeleton robots
Authors: Tang Jinyu
Published: January 2024

The purpose of this paper is to compare and evaluate the performance differences between flexible and rigid hand exoskeletons in terms of functional recovery and assistance in daily activities.Flexible hand exoskeletons are lightweight and soft devices with stretchable materials and flexible mechanisms designed to mimic the flexibility and versatility of natural hand movements.They typically consist of elastic materials, sensors and actuators that enable natural hand movements and provide light strength support.The main advantages of flexible hand exoskeletons are their comfort and flexibility, and their ability to provide personalized assistance for a variety of daily activities and tasks.This form of design is suitable for patients who require mild hand support and dexterity, such as individuals with mildly impaired hand motor function or who need to perform fine motor movements. In contrast, a rigid hand exoskeleton is a more rigid and stable device that uses robust materials and a rigid mechanism designed to provide a greater degree of strength support and stability.They are typically constructed of metal or composite materials, have a high degree of rigidity and stability, and provide strength support through electrical motors or hydraulic systems.The main advantage of a rigid hand exoskeleton is its higher force output and stability for tasks that require higher loads or complex movements.This form of design is suitable for patients who require greater strength support and stability, such as individuals with reduced hand muscle strength or who need to carry heavy loads
Analysis of the development of an STM32-based smartwatch
Authors: Zhang Zhiyuan
Published: January 2024

Sensors and microcontrollers are well-functioning and inexpensive, and the smartwatch industry continues to grow. In response to the problems of traditional smartwatches, which are not fully functional, have poor computing effectiveness and are not suitable for wearing, this thesis designs a smartwatch based on the STMicroelectronics NUCLEO-L476RG microcontroller, using Altium Designer 17 software to draw The schematic diagram and Printed Circuit Board are drawn using Altium Designer 17 software, the driver code of the sensor is compiled and integrated using MBED software, the signal is processed by the STMicroelectronics NUCLEO-L476RG microcontroller and displayed in the Organic Light-Emitting Diode with Bluetooth debugger The measured parameters, such as heart rate, ambient temperature, number of steps, latitude and longitude, are displayed in the Organic Light-Emitting Diode with Bluetooth debugger. The results of the study show that the transmission of the signals in the STMicroelectronics NUCLEO-L476RG microcontroller and the display of the signals in the Organic Light-Emitting Diode and Bluetooth debugger have the advantages of small size, perfect functionality and low energy consumption, making it convenient for the user's daily use.
Comparison of machine learning models for the estimation of solar power generation in Australia
Authors: Han Zhuowen
Published: January 2024

Solar power is a renewable energy source that contributes a lot to improving the environmental sustainability of energy production. In Australia, rooftop solar panel systems are installed for power generation. By seeking the optimal installation strategy, people could develop more efficient technologies and systems. In this work, data related to power generation was gathered between January 1 and December 31, 2022. This article only analyzes qualitative data in the dataset. Firstly, the support vector machine (SVM) model is used to compare the results obtained by removing only one qualitative feature at a time with the results obtained by including all features. It is concluded that the shading condition feature has a significant impact on power generation, and then. By comparing the accuracy of K-nearest neighbor (KNN), Logistic Regression, SVM with Radial Basis Function (RBF) kernel, and Decision Tree, it was found that SVM with RBF kernel is the most suitable classification method for the feature of the shading condition.
The impact of mobile social media use on the integration of immigrants -- With empirical evidence from China
Authors: Huang Wenjie
Published: January 2024

Mobile social media, along with the rapid development of the mobile Internet, has injected more vivid vitality into the cross-cultural adaptation of foreign immigrants. Based on the cross-cultural adaptation model, this paper investigated 275 foreign immigrants to China and analyzed the impact of mobile social media use on cross-cultural adaptation. It was found that mobile social media use has a significant positive effect on cross-cultural adaptation and that the news access function, tool-type applets, and unique online subcultures provided by social media can help foreign immigrants to understand China more deeply from different perspectives. China. This paper not only enriches the research on cross-cultural adaptation but also further highlights the role of mobile social media in promoting social development and progress.
Research on the fast geolocation algorithm based on Bloom filter
Authors: Wang Weitong
Published: January 2024

With the rapid development of geolocation information services, which involves large-scale location data querying, including map data and user location data. Traditional data storage and query methods face challenges of storage space and query efficiency, and the ability to process real-time geolocation data becomes critical in Geographic Information Services positioning systems that require servers to achieve millisecond-level response speeds. In addition to this, in geolocation services, for a given latitude and longitude information, it is necessary to quickly determine whether it exists or matches some specific location in the map service. The common traditional information finding algorithm in geographic location service is B-tree, and this paper proposes a geographic location information finding algorithm based on the Bloom filter, which mainly solves two problems. One is the storage problem of large amounts of latitude and longitude information; the other is how to convert the data stored in bytes level to bits level, which greatly reduces the space complexity and the inefficient information finding. The Bloom filter reduces the query time to linear time complexity O(n). The fastest query time for 5 million items of latitude and longitude information can reach 3.12 seconds. This article will illustrate the efficiency of the proposed method through a real-time traffic navigation scenario.
Investigation of medical image segmentation techniques and analysis of key applications
Authors: Dong Hao
Published: January 2024

This research examines the application of the UNet convolutional neural network model, specifically for semantic segmentation tasks in the field of medical imaging, juxtaposing its efficacy with Fully Convolutional Networks (FCNs). The primary focus of this comparative analysis rests on the performance of the UNet model on the dataset employed for this study. Surpassing our initial expectations, the UNet model demonstrated remarkable performance superiority over the FCN model on the curated dataset, thereby suggesting its potential applicability and utility for analogous tasks within the realm of medical imaging. In a surprising turn of events, our trials revealed that data augmentation techniques did not usher in a notable enhancement in segmentation accuracy. This observation was especially striking given the substantial size of the dataset employed for the experiments, encompassing as many as 1000 images. This outcome suggests that the merits of data augmentation may not always come to the fore when dealing with considerably large datasets. This intriguing discovery prompts further exploration and investigation to uncover the underlying reasons behind this observed phenomenon. Moreover, it brings to light an open-ended research query - the quest for alternative methodologies that could potentially amplify segmentation accuracy when operating on large scale datasets in the sphere of medical imaging. As the field continues to evolve and mature, it is these open questions that will continue to push the boundaries of what is possible in medical image analysis.
A study of human pose estimation in low-light environments using YOLOv8 model
Authors: Gu Kaiming , Su Boyu
Published: January 2024

Human pose estimation is a formidable task in the field of computer vision., often constrained by limited training samples and various complexities encountered during target detection, including complex backgrounds, object occlusion, crowded scenes, and varying perspectives. The primary objective of this research paper is to explore the performance disparities of the recently introduced YOLOv8 model in the context of human pose estimation. We conduct a comprehensive evaluation of six different models with varying complexities on the same low-light photograph to assess their precision and speed. The objective is to determine the suitability of each model for specific environmental contexts. The experimental results reveal that our findings demonstrate a partial regression in accuracy for the yolov8s-pose and yolov8m-pose models when tested on our sampled images. The increase in model layers indicates enhanced complexity and expressive power, while additional parameters signify improved learning capabilities at the expense of increased computational resource requirements.
Research on performance comparison of patrol path planning techniques for mobile robots in nuclear power plants
Authors: Liu Shuying
Published: January 2024

Path planning, as a basic problem of mobile robots, is important in the application of industrial patrol robots. This paper takes the nuclear power plant as an example and solves the problem of multi-target patrol path of patrol robot. Firstly, this paper processes multi-target points applying Euler's formula to obtain a reasonable order of patrol target points. Then three path planning algorithms, A* algorithm based on graph search, RRT* algorithm based on sampling and Q-learning algorithm based on reinforcement learning, are applied on path planning, and combined with Minimal-Jerk algorithm for optimizing trajectories. The performance of the results is finally compared using two evaluation metrics. The acceleration variance and route analysis in planar images are used as evaluation metrics in this paper. It is considered that the smaller the acceleration variance, the more smoothly the robot can move. The gentler the route is, the more effective the robot movement is.
Employing the BERT model for sentiment analysis of online commentary
Authors: Li Bowen , Liu Xiaolu , Zhang Ruijia
Published: January 2024

The objective of this research is to carry out a tone and semantic sentiment analysis of network comments on new media platforms by leveraging the BERT model. With the burgeoning popularity of social media, network comments, rich in emotional and tonal features, have emerged as a significant part of the online culture. Accurate interpretation and analysis of these comments' sentiment and semantic meanings are paramount to grasping online public opinion and user psychology. In this study, the BERT model, lauded for its bidirectional encoding and contextual understanding capabilities, is selected to scrutinize the sentiment and tone of network comments on new media platforms. Through a process of pre-training and fine-tuning, the sentiment attitudes and polarity of comments are accurately identified along with their conveyed tonal features, such as joy, anger, and sarcasm. Conducting an accurate tone and semantic sentiment analysis of network comments on new media platforms facilitates a profound understanding of user preferences and trends in public opinion. This can assist in optimizing content recommendations, enhancing user experiences, and increasing the operational effectiveness of new media platforms. The outcomes of this research will bear significant implications for studies and applications in online culture, offering invaluable references and guidance in related domains.
Determining the Concentration Rates of Gibberellic Acid (GA3) as Ripening Inhibitor of Lakatan Banana (Musa acuminata AAA Group)
Authors:   https://orcid.org/0009-0000-2221-1456, https://orcid.org/0009-0007-3977-7721, https://orcid.org/0009-0000-6056-6676 zbenjie51@gmail.com, rpenora@gmail.com, jeybuseprado0482@gmail.com Kapalong College of Agriculture, Sciences and Technology Maniki, Kapalong, Philippines, Zamora Benjie , A. Peñora Rowel , L. Seprado Jebuchadnezzar
Published: January 2024

Lakatan (Musa acuminata AAA Group) is one of the most essential banana variety commodities in the Philippines as a tropical country. This present study was conducted to determine and investigate the effects of (GA3) Gibberellic Acid in different concentration rates as post-harvest treatments on the shelf life and quality of bananas like physiological weight, peel color, and its pulp-to-peel ratio to determine which of treatments can prolong the shelf life of the banana; and to evaluate the most effective rates of GA3 that have the highest efficacy against the rapid ripening activity of ‘Lakatan’ banana variety as well as banana sample are soaked into the different concentration of treatment with the duration of five minutes then air dried for ten minutes and put into a polyethylene plastic cellophane which was open with cardboard boxes in each replication and placed under room temperature. This study was arranged in a Completely Randomized Design (CRD) with five treatments and replicated three times. The treatments were: where T1 – is a control which contains 1000 ml pure distilled water, T2 -consists of 100 ml GA3 mixed with 900 ml water, T3 -comprised of 200 ml GA3 mixed with 800 ml water, T4 – consists of 300 ml GA3 mixed with 700 ml water and T5 – contained 400 ml GA3 mixed with 600 ml water. This design was utilized to show the results intended for this study. Results of the study revealed highly significant differences among using different concentration rates of plant growth hormones GA3 as post-harvest treatments like cumulative physiological loss in weight, shelf life, peel color index, pulp peel ratio, No. Of days that the samples start to ripen, no. of ripe fingers, no. of unripe fingers, no. of days that all the models are fully unripe, and no of days that the pieces are fully ripened. Keywords: plant growth hormones, ripening, Lakatan, Musa, postharvest, distilled water, gibberellic acid
Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats
Authors: Mudhol Mahesh , Gondi Surendra , C Reddyprasad
Published: January 2024

Background: Thiophene, also known as thiofuran, is a heterocyclic molecule represented by the chemical formula C4H4S.

Aims and Objectives: The aim of this study was to evaluate the anti-inflammatory activity of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound in Wistar rats by acute carrageenan-induced paw edema and chronic cotton pellet-induced granuloma methods.

Materials and Methods: This study consists of two stages: An acute inflammation study using carrageenan-induced paw edema in rats, which involves four groups of rats, and a chronic inflammation study using cotton pellet-induced granuloma, which involves three groups of rats. Mean paw edema volume and percentage of inhibition were measured in acute stage. The mean weight of the pellets in each group was determined during the chronic stage.

Results: There was increase in the mean paw volume at 3 h and a slow decrease at 6 h and 24 h in control group to thiophene derivative-20 mg/kg/p.o from 0 h to 24 h. The mean difference from control and at 3 h, 6 h, and 24 h showed that mean difference was slowly decreased and it was statistically significant. The mean dry granuloma weight in control group, i.e., 10% tween 80 treated group was 146.6 ± 4.38. The mean dry granuloma weight in standard group, i.e., indomethacin 3 mg/kg treated group was 87.7 ± 3.41. The mean dry granuloma weight in substituted thiophene 10 mg/kg group was 101.91 ± 3.76.

Conclusions: The newly synthesized substituted (fused) thiophene compound demonstrated inhibition of inflammation in both acute inflammation induced by carrageenan-induced paw edema and chronic inflammation induced by cotton pellet-induced granuloma in Wistar rats. The compound’s anti-inflammatory effects were comparable to those of the standard drug indomethacin, with a dosage of 10 mg/kg in the acute model and 3 mg/kg in the chronic inflammation model. This concludes that the test compound has anti-inflammatory activity.
Antik Roma Gündelik Hayatında Hijyen Kavramı
Authors: GÜÇLÜ Deniz
Published: January 2024

Antik Roma, tarih boyunca büyük bir medeniyet olarak öne çıkar, ancak günlük hayatlarında hijyen konusundaki uygulamaları günümüz standartlarından oldukça farklıydı. Roma İmparatorluğu'nda, insanlar temizlik ve hijyen konularına değer verseler de ancak günümüz sanitasyon standartlarına uygun bir yaşam tarzı sürdürmekte zorlanıyorlardı. Antik Roma'nın mühendislik başarıları, suyun etkin bir şekilde taşınmasını sağlayan su kemerleri, borular, kanallar ve sarnıçlar gibi sistemleri içeriyordu. Bu sistemler sayesinde su, çeşmelerden hamamlara, tuvaletlere ve villalara ulaştırılarak önemli bir kamu hizmeti sunuluyordu. Hamamlar, sadece temizlik yerleri değil, aynı zamanda toplumun değerlerine uygun eğlence, öğrenme ve sosyalleşme mekânlarıydı. Her kesimden insan, soylu ya da köle ayrımı olmaksızın, hamam hizmetlerinden faydalanırdı ve günün önemli ziyaretlerinden biri olarak kabul edilirdi. Latrinalar da, Roma'da hem umumi tuvaletler hem de halk sağlığı için önemli yapılar arasında yer alıyordu. Bu yapılar, Roma'nın vazgeçilmez mekânlarıydı. Antik Roma toplumu, kişisel hijyenlerini sağlamak için doğal malzemelerden, özellikle zeytinyağı ve kumdan sıklıkla yararlanıyordu. Bu dönemdeki hijyen alışkanlıkları, tarihsel ve kültürel bir bakış açısıyla incelendiğinde, Antik Roma'nın yaşam tarzının benzersiz ve ilginç yönlerini ortaya koymaktadır. Çalışmamızda antik kaynaklar ışığında bir Roma vatandaşının kişisel hijyenini günlük hayatta nasıl sağladığı, hangi hizmetlerden ve yapılardan yararlandığı incelenmiştir.
A FORMAÇÃO DOCENTE SUA DIFICULDADE EM INSERIR NOVAS TECNOLOGIAS NO CURRÍCULO: O CURRÍCULO ESCOLAR E A IMPLEMENTAÇÃO DE NOVAS TECNOLOGIAS
Authors: Santos Silvana Maria Aparecida Viana , Caetano Adna , De Carvalho Ianan Eugênia , Dias Fernando Mota , Pereira Filomena Alves , Meroto Monique Bolonha das Neves , Moniz Sibele Selvina de Oliveira Rodrigues , Rigo Tatiana Afonso Tavares
Published: January 2024

Este estudo focalizou a questão crítica de incorporar tecnologias emergentes no currículo escolar como parte da formação de professores. Seu principal objetivo era identificar e analisar os desafios enfrentados pelos educadores nesse processo, bem como desenvolver estratégias para superá-los. A abordagem metodológica adotada foi a revisão bibliográfica, que envolveu o exame de literatura relevante sobre teorias de aprendizagem, metodologias ativas, inovações tecnológicas e a interação entre currículo e tecnologia. Os resultados identificaram obstáculos significativos, incluindo a insuficiência de treinamento específico dos professores para a utilização eficiente de tecnologias, a relutância em modificar métodos de ensino tradicionais e a inadequação das infraestruturas escolares. A análise sugeriu a necessidade de uma abordagem integrada na adoção de tecnologia, que considerasse investimentos em infraestrutura, aprimoramento da formação docente e uma reavaliação das práticas de ensino. O estudo concluiu enfatizando a importância vital de um desenvolvimento profissional contínuo e adaptável para professores, juntamente com a necessidade de um currículo que responda às demandas da era digital. Destacou-se também o compromisso com a inovação constante e o aperfeiçoamento do sistema educacional, preparando os alunos para um futuro marcado por avanços tecnológicos contínuos.
CONTRIBUIÇÃO DA NEUROPSICOLOGIA COM ALUNOS PORTADORES DE AUTISMO
Authors: De Carvalho Ianan Eugênia , Santana Alexandre Jesus Serrat , De Souza Juliana Lima , Meroto Monique Bolonha das Neves , Santos Silvana Maria Aparecida Viana , Moreira Maria da Fé Silva , Lordes Josinete Braga Borges , Martins Sara Sobreiro
Published: January 2024

Este estudo abordou o problema da contribuição da neuropsicologia no desenvolvimento educacional de alunos com Transtorno do Espectro Autista (TEA). O objetivo geral foi analisar como abordagens neuropsicológicas podem aprimorar a educação e a inclusão desses alunos. A metodologia adotada consistiu em uma revisão de literatura, com coleta e análise de fontes acadêmicas diversas. Os resultados indicaram a eficácia de estratégias educacionais adaptadas, como o uso de tecnologias assistivas, realidade virtual e aumentada, e práticas de ensino ativo. Foi constatada a importância da formação contínua de educadores e do envolvimento de família e comunidade no processo educativo. A análise destacou a necessidade de práticas educacionais inovadoras, inclusivas e baseadas em conhecimentos neuropsicológicos. As considerações finais reiteram a relevância de abordagens adaptativas, colaboração entre educadores, famílias e comunidades para um ambiente educacional eficaz e acolhedor para alunos com TEA. Estas práticas promovem a inclusão, o desenvolvimento acadêmico, emocional e social dos alunos.
PRECEDENTES JUDICIAL DA DICOTOMIA: MERCADORIA OU SERVIÇOS DIGITAIS
Authors: Dallacosta Victor Schleder
Published: January 2024

O presente artigo tem como objetivo analisar a flexibilidade de interpretação das normas de competência tributária e como essas são aplicadas aos novos institutos criados pelas novas tecnologias. Através da revisão doutrinaria e da análise de diversos precedentes do Supremo Tribunal Federal, busca-se a construção de uma fundamentação para a separação das competências tributarias, assim como delimitada pela Constituição. Ao final conclui-se que: i.  a Constituição Federal delimita as competências tributarias a partir da eleição de materialidades abstratas, que possuem conteúdo amplo e mutável, possibilitando a interpretação conforme os preceitos Constitucionais, respeitando a legalidade e as devidas reservas legais; ii. que a atualização dos conceitos ocorre pela interpretação, seja pela doutrina ou pela jurisprudência; iii. que a utilização do sistema de precedentes, que foi introduzido pelo Código de Processo Civil de 2015, ainda é muito influenciada pela cultura do Civil Law e, por isso, ainda não conseguiu atribuir a perenidade para as decisões judiciais.
A INCLUSÃO E OS GRANDES DESAFIOS PARA EDUCAÇÃO
Authors: Batista Rosemeri Liborio Ferreira , Dos Anjos Priscila Ramos de Freitas , Brites Christiana Roberto , Balbino Renata Tosta Fernandes , De Freitas Deisy Aparecida Rezende , Barolli Giovanni Sérgio Leal , De Oliveira Simone Dias , De Oliveira Luciana Almeida Costa , Fernandes Fernnanda Luciano
Published: January 2024

Este artigo aborda a educação inclusiva como um compromisso vital com a equidade e diversidade, indo além de discursos igualitários. Destaca-se a transformação cultural necessária nas instituições educacionais para superar desafios intrincados, exigindo uma mudança profunda nas percepções e atitudes. A diversidade de necessidades educacionais destaca a importância da individualização do ensino, utilizando abordagens pedagógicas inovadoras. Os educadores têm um papel central na promoção da inclusão, necessitando de formação continuada para desenvolver estratégias pedagógicas inclusivas. A tecnologia é apresentada como uma aliada poderosa na personalização do aprendizado, atendendo às necessidades individuais dos alunos. Além disso, destaca-se a importância das políticas públicas na criação de um ambiente propício para a educação inclusiva, garantindo recursos e diretrizes claras. O compromisso vital com a educação inclusiva vai além da igualdade formal, exigindo uma mudança cultural. A metodologia adotada segue a abordagem de estudo de caso proposta por Yin, com uma revisão bibliográfica sistemática nos últimos 10 anos. A seção sobre o compromisso vital destaca que a educação inclusiva vai além da conformidade com padrões igualitários, sendo um ato político e ético. Os pilares da inclusão efetiva envolvem educadores, tecnologia e políticas públicas.
COLANGIOCARCINOMA E CARCINOMATOSE PERITONEAL: UMA DISCUSSÃO DE CASO
Authors: Arêdes Franciele Maria Pires , Gonçalves Geovane Henrique , Pires Alencar Arêdes , Parmagnani Isabela Carneiro , Parmagnani Lucas Carneiro
Published: January 2024

O Colangiocarcinoma (CCA), é um tumor raro e agressivo, que se origina nos ductos biliares, representa a segunda neoplasia hepática mais frequente, instituindo 3% de todos os cânceres gastrointestinais. Esta neoplasia, desenvolve-se a partir da transformação maligna de colangiócitos, cuja carcinogênese é bastante complexa, resultado de uma cascata de anormalidades genéticas e metabólicas.¹ É classificado conforme a sua localização, em intra-hepático, perihilar (tumor de Klatskin) e distal. A sua principal manifestação clínica é a icterícia, de caráter obstrutivo.² Quando associado à Carcinomatose Peritoneal, a complexidade do tratamento aumenta significativamente, ao estar relacionado à Carcinomatose Peritoneal Secundária (metastática). Este artigo atualiza conhecimentos epidemiológicos, fisiopatológicos, terapêuticos e principalmente diagnósticos do CCA e Carcinomatose Peritoneal.
Caracterización de madres de pacientes con exposición perinatal al Virus de Inmunodeficiencia Humana
Authors: González Figueroa Adriana , Rodríguez Minaya Edelin , Siciliano Sabatela Luigina , López García María , Nexans Miguel Ángel , Yanes Rojas Andreina , Moreno Juan José
Published: January 2024

La mayor incidencia de la infección por el virus de inmunodeficiencia humana (VIH) en mujeres ha tenido un impacto directo en la transmisión vertical, situación que puede ser evitada con un adecuado control prenatal.
GLASSFIBRE REINFORCED POLYMER WITH EMBEDDED ADDITIVES
Authors: Journal IJSREM
Published: January 2024

This study investigates the synergistic effects of incorporating additives within glass reinforced polymer (GRP) composites to enhance their mechanical, thermal, and durability properties. The research focuses on optimizing the dispersion and interaction of additives within the polymer matrix to achieve improved structural performance. Through a systematic experimental approach, the study aims to establish the influence of various additives on the tensile strength, impact resistance, and thermal stability of GRP composites. The findings contribute to advancing the understanding of composite materials and offer insights into tailoring their properties for specific engineering applications, such as aerospace, automotive, and construction. Key Words: Structural Performance, Mechanical Properties, Thermal Stability, Durability, Polymer Matrix, Tensile Strength, Impact Resistance