bluuebunny/crossref_metadata_2025 huggingface dataset:
Conversion of mild cognitive impairment patients in Alzheimer’s disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio
Authors: Moretti D. V.
Published: December 2015

Introduction

The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer’s disease (AD).

Methods

Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has been evaluated after a three years follow-up. Twenty-seven of these subjects underwent perfusion single-photon emission computed tomography (SPECT) evaluation also. Increasing alpha3/alpha2 power ratio, was computed for each subject. Differences in EEG markers, cortical thickness, brain perfusion among the groups were estimated.

Results

In the higher alpha3/alpha2 frequency power ratio group, greater memory impairment was correlated with greater cortical atrophy and lower perfusional rate in the temporo-parietal cortex. After a follow-up of three years, these patients converted in AD.

Conclusion

High EEG upper/low alpha power ratio was associated with cortical thinning and lower perfusion in the temporo-parietal lobe. Moreover, atrophy and lower perfusion rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in the clinical context.
C-arm computed tomography parenchymal blood volume measurement in evaluation of hepatocellular carcinoma before transarterial chemoembolization with drug eluting beads
Authors: Syha Roland , Grözinger Gerd , Grosse Ulrich , Maurer Michael , Zender Lars , Horger Marius , Nikolaou Konstantin , Ketelsen Dominik
Published: December 2015

Background

C-arm computed tomography (CT) guided intervention is an increasingly applied technique in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). The aim of this study was to analyse the value of parenchymal blood volume (PBV) maps acquired during C-arm CT acquisition, for pre-treatment evaluation and planning of TACE in HCC patients.

Methods

A total of 64 HCC lesions in 29 patients (median age, 73 years, range, 62–77 years) were included in this retrospective study. All patients received cross-sectional imaging (MRI or CT) prior to TACE and C-arm CT PBV measurement acquisition before performing TACE. Results of cross-sectional imaging regarding the number of HCC lesions and maximum diameter were compared to PBV–maps. Number of lesions and tumour feeding vessels detected in PBV-maps were compared to conventional angiography. Results of PBV were analysed concerning different tumour morphologies (pre-treated, encapsulated and diffuse).

Results

Pre-interventional cross-sectional imaging and PBV maps showed an excellent agreement in lesion diameter (p = 0.88, MD = −0.28 mm) and number of detected lesions (κ = 1.0). Compared to conventional angiography, PBV maps showed an increased number of detected lesions (κ = 0.77, p = 0.001) and tumour feeding vessels (κ = 0.71, p < 0.0001). Diffuse HCC lesion revealed a significantly lower PBV compared to encapsulated lesions (p = 0.0001).

Conclusions

C-arm CT acquired PBV measurements detect HCC tumours with a lesion detectability comparable to pre-interventional cross-sectional imaging. Furthermore, this technique facilitates TACE, allowing a more precise localization of HCC lesions and tumour feeding vessels compared to conventional angiography. Additionally, calculated PBV values enable a real time quantitative assessment of tumour perfusion.
Altered chemotactic response to CXCL12 in patients carrying GATA2 mutations
Authors: Maciejewski-Duval Anna , Meuris Floriane , Bignon Alexandre , Aknin Marie-Laure , Balabanian Karl , Faivre Laurence , Pasquet Marlène , Barlogis Vincent , Fieschi Claire , Bellanné-Chantelot Christine , Donadieu Jean , Schlecht-Louf Géraldine , Marin-Esteban Viviana , Bachelerie Francoise
Published: December 2015

GATA2 deficiency—formerly described as MonoMAC syndrome; dendritic cells, monocytes, B cells, and natural killer cell deficiency; familial myelodysplastic syndrome/acute myeloid leukemia; or Emberger syndrome—encompasses a range of hematologic and nonhematologic anomalies, mainly characterized by monocytopenia, B lymphopenia, natural killer cell cytopenia, neutropenia, immunodeficiency, and a high risk of developing acute myeloid leukemia. Herein, we present 7 patients with GATA2 deficiency recruited into the French Severe Chronic Neutropenia Registry, which enrolls patients with all kinds of congenital neutropenia. We performed extended immunophenotyping of their whole blood lymphocyte populations, together with the analysis of their chemotactic responses. Lymphopenia was recorded for B and CD4+ T cells in 6 patients. Although only 3 patients displayed natural killer cell cytopenia, the CD56bright natural killer subpopulation was nearly absent in all 7 patients. Natural killer cells from 6 patients showed decreased CXCL12/CXCR4-dependent chemotaxis, whereas other lymphocytes, and most significantly B lymphocytes, displayed enhanced CXCL12-induced chemotaxis compared with healthy volunteers. Surface expression of CXCR4 was significantly diminished in the patients’ natural killer cells, although the total expression of the receptor was found to be equivalent to that of natural killer cells from healthy individual controls. Together, these data reveal that GATA2 deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4. These dysfunctions may contribute to the physiopathology of this deficiency by affecting the normal distribution of lymphocytes and thus potentially affecting the susceptibility of patients to associated infections.
Long-Term Results of the HD2000 Trial Comparing ABVD Versus BEACOPP Versus COPP-EBV-CAD in Untreated Patients With Advanced Hodgkin Lymphoma: A Study by Fondazione Italiana Linfomi
Authors: Merli Francesco , Luminari Stefano , Gobbi Paolo G. , Cascavilla Nicola , Mammi Caterina , Ilariucci Fiorella , Stelitano Caterina , Musso Maurizio , Baldini Luca , Galimberti Sara , Angrilli Francesco , Polimeno Giuseppe , Scalzulli Potito Rosario , Ferrari Angela , Marcheselli Luigi , Federico Massimo
Published: December 2015

Purpose

The randomized HD2000 trial compared six cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), four escalated plus two standard cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone), and six cycles of COPP-EBV-CAD (cyclophosphamide, lomustine, vindesine, melphalan, prednisone, epidoxorubicin, vincristine, procarbazine, vinblastine, and bleomycin; CEC) in patients with advanced-stage Hodgkin lymphoma. After a median follow-up of 42 months, patients who received BEACOPP were reported to have experienced better progression-free survival (PFS) but not better overall survival (OS) results than those receiving ABVD. We here report a post hoc analysis of this trial after a median follow-up of 10 years.

Patients and Methods

Three hundred seven patients were enrolled, 295 of whom were evaluable. At the time of our analysis, the median follow-up for the entire group was 120 months (range, 4 to 169 months).

Results

The 10-year PFS results for the ABVD, BEACOPP, and CEC arms were 69%, 75%, and 76%, respectively; corresponding OS results were 85%, 84%, and 86%. Overall, 13 second malignancies were reported: one in the ABVD arm and six each in the BEACOPP and CEC arms. The cumulative risk of developing second malignancies at 10 years was 0.9%, 6.6%, and 6% with ABVD, BEACOPP, and CEC, respectively; the risk with either BEACOPP or CEC was significantly higher than that reported with ABVD (P = .027 and .02, respectively).

Conclusion

With these mature results, we confirm that patients with advanced Hodgkin lymphoma have similar OS results when treated with ABVD, BEACOPP, or CEC. However, with longer follow-up, we were not able to confirm the superiority of BEACOPP over ABVD in terms of PFS, mainly because of higher mortality rates resulting from second malignancies observed after treatment with BEACOPP and CEC.
Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab
Authors: Rosenthal David I. , Harari Paul M. , Giralt Jordi , Bell Diana , Raben David , Liu Joyce , Schulten Jeltje , Ang Kian K. , Bonner James A.
Published: December 2015

Purpose

We conducted a retrospective evaluation of the IMCL-9815 study to examine the association of human papillomavirus (HPV) and p16 protein expression status with outcomes in patients with oropharyngeal carcinoma (OPC) receiving radiotherapy (RT) plus cetuximab or RT alone.

Patients and Methods

In the IMCL-9815 study, patients were randomly allocated to receive RT plus weekly cetuximab or RT alone. A subpopulation of patients with p16-evaluable OPC was retrospectively evaluated on the basis of locoregional control (LRC), overall survival (OS), and progression-free survival (PFS). Evaluable samples from patients with p16-positive OPC were also tested for HPV DNA.

Results

Tumor p16 status was evaluable in 182 patients with OPC enrolled in the IMCL-9815 study; 41% were p16 positive. When treated with RT alone or RT plus cetuximab, p16-positive patients had a longer OS than p16-negative patients (hazard ratio, 0.40; 95% CI, 0.21 to 0.74 and hazard ratio, 0.16; 95% CI, 0.07 to 0.36, respectively). The addition of cetuximab to RT increased LRC, OS, and PFS in both patients with p16-positive OPC and those with p16-negative disease. Interaction tests for LRC, OS, and PFS did not demonstrate any significant interaction between p16 status and treatment effect (P = .087, .085, and .253, respectively). Similar trends were observed when patients with p16-positive/HPV-positive OPC (n = 49) and those with p16-positive/HPV-negative OPC (n = 14) were compared.

Conclusion

p16 status was strongly prognostic for patients with OPC. The data suggest that the addition of cetuximab to RT improved clinical outcomes regardless of p16 or HPV status versus RT alone.
Urocortin 2 But Not Urocortin 3 Promotes the Synaptic Formation in Hipppocampal Neurons via Induction of NGF Production by Astrocytes
Authors: Zheng You , Zhang Yan-Min , Ni Xin
Published: December 2015

CRH family peptides play differential role during various physiological and pathophysiological responses, such as stress. Urocortins (UCNs) have been implicated to play complementary or contrasting actions for the effects of CRH during stress. It has been shown that activation of CRH receptor type 1 (CRHR1) results in decreased synapse formation in hippocampus. We therefore explored the effect of UCN2 and UCN3, the exclusive CRHR2 agonists, on synaptic formation in hippocampus. In hippocampal slices cultures, UCN2 but not UCN3 treatment increased the levels of presynaptic protein synapsinI and postsynaptic protein postsynaptic density 95 (PSD95), which was reversed by CRHR2 antagonist astressin 2B. In isolated hippocampal neurons, however, UCN2 decreased the numbers of synapsinI- and PSD95-labeled terminals/clusters via CRHR2. Treatment of hippocampal neurons with the media of UCN2-treated astrocytes led to an increase in synapsinI- and PSD95-labeled terminals. In neuron-astrocyte cocultures, UCN2 also enhanced the numbers and level of synapsinI- and PSD95-labeled terminals. These effects did not occur if glial cells were transfected with CRHR2 small interfering RNA. UCN2 but not UCN3 treatment induced nerve growth factor (NGF) production in astrocytes via CRHR2. The effects of the media of UCN2-treated glial cells on synapse formation in hippocampal neurons were prevented by administration of NGF receptor antagonists. Our data indicate that UCN2 promotes synapse formation in hippocampus via induction of NGF secretion from astrocytes. CRHR2 in glial cells mediates the stimulatory effects of CRH. Glia-neuron communication is critical for neuronal circuits remodeling and synaptic plasticity in response to neurohormones or neuromodulators.
Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition
Authors: Damerill Ian , Biggar Kyle K. , Abu Shehab Majida , Li Shawn Shun-Cheng , Jansson Thomas , Gupta Madhulika B.
Published: December 2015

In fetal growth restriction (FGR), fetal growth is limited by reduced nutrient and oxygen supply. Insulin-like growth factor I (IGF-I) is a key regulator of fetal growth and IGF binding protein -1(IGFBP-1) is the principal regulator of fetal IGF-I bioavailability. Phosphorylation enhances IGFBP-1's affinity for IGF-I. Hypoxia induces IGFBP-1 hyperphosphorylation, markedly decreasing IGF-I bioavailability. We recently reported that fetal liver IGFBP-1 hyperphosphorylation is associated with inhibition of the mechanistic target of rapamycin (mTOR) in a nonhuman primate model of FGR. Here, we test the hypothesis that IGFBP-1 hyperphosphorylation in response to hypoxia is mediated by mTOR inhibition. We inhibited mTOR either by rapamycin or small interfering RNA (siRNA) targeting raptor (mTOR complex [mTORC]1) and/or rictor (mTORC2) in HepG2 cells cultured under hypoxia (1% O2) or basal (20% O2) conditions. Conversely, we activated mTORC1 or mTORC1+mTORC2 by silencing endogenous mTOR inhibitors (tuberous sclerosis complex 2/DEP-domain-containing and mTOR-interacting protein). Immunoblot analysis demonstrated that both hypoxia and inhibition of mTORC1 and/or mTORC2 induced similar degrees of IGFBP-1 phosphorylation at Ser101/119/169 and reduced IGF-I receptor autophosphorylation. Activation of mTORC1+mTORC2 or mTORC1 alone prevented IGFBP-1 hyperphosphorylation in response to hypoxia. Multiple reaction monitoring-mass spectrometry showed that rapamycin and/or hypoxia increased phosphorylation also at Ser98 and at a novel site Ser174. In silico structural analysis indicated that Ser174 was in close proximity to the IGF-binding site. Together, we demonstrate that signaling through the mTORC1 or mTORC2 pathway is sufficient to induce IGFBP-1 hyperphosphorylation in response to hypoxia. This study provides novel understanding of the cellular mechanism that controls fetal IGFBP-1 phosphorylation in hypoxia, and we propose that mTOR inhibition constitutes a mechanistic link between hypoxia, reduced IGF-I bioavailability and FGR.
Method activation end date in the past. direction:re
Authors: Петров Александр , Petrov Aleksandr
Published: December 2015

This article is devoted to answering the questions related to the theory of conflicts in law. Particularly, there are discovered two main approaches to understanding of such conflicts – objective and subjective one. Besides, author tries to make clear the discussion: is the phenomenon of conflict in law explored in frame of private international law equal to the object named-so in the theory of law. The article includes the describing of vital characteristics of conflict in law. Also author rises up the question of objects which may serve as basics for any contradiction to come up. Additionally, the article emphasizes why the concurrence of norms is considered to be a conflict between general and special norms.
Method activation end date in the past. direction:re
Authors: Шамсетдинова Алина , Shamsetdinova Alina
Published: December 2015

Consideration of the circumstances, exempt from international responsibility, provided in accordance with the Statute of the International Criminal Court. It raises the question of relevance in considering the process of establishing this institution, and especially the use of grounds for exemption from international criminal responsibility.
EFEK PENYIMPANAN BIODIESEL BERDASARKAN STUDI KAJIAN DEGRADASI BIODIESEL CPO
Authors: Silviana Silviana , Buchori Luqman
Published: December 2015

BIODIESEL STORAGE EFFECT BASED ON DEGRADATION OF CPO BIODIESEL Biodiesel denotes as ester mono alkyl of long chain fatty acid such as CPO (crude palm oil) which can biologically degrade more than 98% within three (3) weeks, whereas fossil fuel degrade partially only. The objective of research was to investigate degradation of biodiesel during storage. The scope of this research covered the container design, storage condition, initial analysis of CPO biodiesel, and degradation rate during product storage by using oxidation rate of biodiesel. The results showed that there was degradation on CPO biodiesel during product storage. It can be seen from increasing of acid value and saponification number, decreasing of iodine number, increasing of total glycerol value, and decreasing of ester number in biodiesel product. Storage period prediction of biodiesel can be approached by using equation, i.e. 𝑦=0.0012𝑥2−0.0052𝑥+0.0609. In this research, the maximum storage period of CPO biodiesel achieved at 27 weeks. Other result showed that well storage was achieved with closed-galvanized container.Keywords: biodiesel; CPO; degradation; storage period AbstrakBiodiesel merupakan ester mono alkil dari asam lemak rantai panjang, seperti CPO (crude palm oil) yang terdegradasi lebih dari 98% secara biologi dalam 3 minggu, sedangkan bahan bakar diesel hanya terdegradasi sebagian. Penelitian ini bertujuan untuk mengamati proses degradasi biodiesel selama masa penyimpanan. Penelitian ini meliputi rancangan tangki biodiesel, kondisi penyimpanan, analisa awal biodiesel, dan studi laju degradasi pada tahap penyimpanan produk dengan ditelaah laju oksidasi pada biodiesel.Hasil penelitian menunjukkan bahwa selama periode proses penyimpanan terjadi proses degradasi biodiesel. Hal ini terlihat dari hasil analisa yang menunjukkan bahwa terjadi kenaikan angka asam selama proses penyimpanan, kenaikan angka penyabunan, penurunan bilangan iodine, kenaikan kadar gliserol total dan penurunan kadar ester di dalam biodiesel. Prediksi periode penyimpanan biodiesel dapat didekati dengan persamaan 𝑦=0,0012𝑥2−0,0052𝑥+0,0609. Dari persamaan tersebut diperoleh bahwa periode maksimal penyimpanan biodiesel adalah 27 minggu. Hasil penelitian juga menunjukkan bahwa penyimpanan biodiesel CPO yang paling baik adalah dengan menggunakan bahan galvanized dengan kondisi penyimpanan yang tertutup.
Synthesis of TiO2 nanotubes by using combination of sonication and hydrothermal treatment and their photocatalytic activity for hydrogen evolution
Authors: Kustiningsih Indar , Slamet S , Purwanto Widodo Wahyu
Published: December 2015

Effect of sonication and hydrothermal treatments on the synthesized of Titania nanotubes (TiO2 NT)has been investigated. Sonication of TiO2 P25 sol was performed using ultrasonic probe for certain time followed by hydrothermal treatment in a teflon lined stainless steel autoclave. The samples were characterized by means of X-ray powder diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), UV-vis diffuse reflectance spectroscopy (UV-vis DRS) and Brunauer-Emmett-Teller (BET).The photocatalytic activity of prepared samples was evaluated with photocatalytic H2 evolution from aqueous methanol solution. The result showed that TiO2 NT was formed rapidly along with the duration of sonication treatment but the longer processing time of it would destroy the morphology of TiO2 NT. The optimal sonication time for the TiO2 NT formation was 10 min. It was obtained TiO2 NT with high crystallinity, high surface area and a perfect nanotubes structure.  Hydrogen production by using this sample was about two times higher than TiO2 P25 nanoparticle.   Keywords : TiO2 nanotubes, sonication, hydrothermal, hydrogen   Abstrak   Efek kombinasi proses sonikasi dan hidrotermal pada pembentukan TiO2 nanotubes telah dilakukan. TiO2 P25 disonikasi menggunakan ultrasonik probe dengan waktu tertentu kemudian dilanjutkan dengan proses hidrotermal di autoklaf berbahan teflon dan stainless steel. Sampel yang diperoleh di karakteriksasi menggunakan X-ray powder diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), UV-vis diffuse reflectance spectroscopy (UV-vis DRS) and Brunauer-Emmett-Teller (BET). Aktifitas fotokatalis dari sampel diuji untuk produksi hidrogen dari larutan metanol. Dari hasil yang diperoleh TiO2 nanotubes lebih cepat terbentuk dengan adanya proses sonikasi, akan tetapi semakin lama waktu sonikasi bentuk nanotubes yang diperoleh menjadi rusak. Waktu optimal untuk proses sonikasi adalah 10 menit. Pada kondisi ini TiO2 yang terbentuk memiliki kristalinitas dan luas permukaan tinggi serta bentuk nanotubes yang sempurna. Produksi hidrogen pada kondisi inipun dua kali lebih besar dibandingkan dengan TiO2 P25 nano partikel.   Kata Kunci : TiO2 nanotubes, sonikasi, hidrotermal, hidrogen
Establishment of primary keratinocyte culture from horse tissue biopsates
Authors: OGOREVC Jernej , LAPANJA Tjaša , POKLUKAR Klavdija , TOMINŠEK Natalija , DOVČ Peter
Published: December 2015

Primary cell lines established from skin tissue can be used in immunological, proteomic and genomic studies as in vitro skin models. The goal of our study was to establish a primary keratinocyte cell culture from tissue biopsates of two horses. The primary keratinocyte cell culture was obtained by mechanical and enzymatic dissociation and with explant culture method. The result was a heterogeneous primary culture comprised of keratinocytes and fibroblasts. To distinguish epithelial and mesenchymal cells immunofluorescent characterisation was performed, using antibodies against cytokeratin 14 and vimentin. We successfully at attained a primary cell line of keratinocytes, which could potentially be used to study equine skin diseases, as an animal model for human diseases, and for cosmetic and therapeutic product testing.
Analysis of type traits of cika sires
Authors: SIMČIČ Mojca , ŠTEPEC Miran , LOGAR Betka , POTOČNIK Klemen
Published: December 2015

The aim of the study was to analyse type traits in 330 Cika sires. Scoring system of Cika cattle includes measured, individual scored and composite scored traits. Individual scored traits are divided into two groups, autochthonousness and form. Three composite traits are autochthonousness, muscularity and form. Fixed part of the model was analysed by GLM procedure in SAS software package, which included the effect of the year and animal age on the scoring day as linear regression. On average, 14.6 months old sires were 117.1 cm high at withers. Immediately, at the end of the scoring procedure all sires were classified into Cika, Semi-Cika and Pinzgauer type, based on the height at withers and individual scored traits from the autochthonous group. This method of classification does not take into account the environmental effects. We found significant effects of the year of scoring and animal age on type traits and therefore on the classification into the type. Sires classification should be carried out after the type traits data evaluation and after the exclusion of environmental effects.
Phase equilibria and thermodynamic properties of oxide systems on the basis of rare earth, alkaline earth and 3d-transition (Mn, Fe, Co) metals. A short overview of
Authors: Cherepanov V. A. , Gavrilova L. Ya. , Volkova N. E. , Urusova A. S. , Aksenova T. V. , Kiselev E. A.
Published: December 2015

Review is dedicated studies of phase equilibria in the systems based on rare earth elements and 3d transition metals. It’s highlighted several structural families of these compounds and is shown that many were found interesting properties for practical application, such as high conductivity up to the superconducting state, magnetic properties, catalytic activity of the processes of afterburning of exhaust gases, the high mobility in the oxygen sublattice and more.
Crystal structure and conductivity of bismuth-containing complex oxides
Authors: Buyanova E. S. , Emelyanova Yu. V. , Morozova M. V. , Mikhailovskaya Z. A. , Kaymieva O. S. , Zhukovskiy V. M. , Petrova S. A.
Published: December 2015

In the paper, a comprehensive systematic study of different classes of bismuth containing oxide compounds was carried out. The relationship between composition, temperature and concentration regions of existence of stable, specific structure and properties of solid solutions on the basis of vanadates, molybdates, niobates and bismuth was found. The general regularities of synthesis of solid solutions with different variants of solid-phase and soluble methods were determined. On this basis, the optimal conditions for obtaining single-phase materials were formulated. For the first time the temperature and concentration boundaries of the regions of homogeneity and areas of stable existence of polymorphic modifications of solid solutions were defined and/or refined. The structural parameters of the synthesized phases were determined. By the method of electrochemical impedance spectroscopy the nature and features of impedance spectra, the temperature and concentration dependences of electrical conductivity of ceramic materials based on bismuth containing complex oxides were identified.
Supervalent doping of LiFePO4 for enhanced electrochemical performance
Authors: Kosova N. V. , Podgornova O. A.
Published: December 2015

The orthophosphates LiFe0.9M0.1PO4 with the structure of olivine doped with vanadium and titanium were obtained by mechanochemically stimulated solidphase synthesis using high-energy planetary mill AGO-2 and subsequent annealing at 750 °C. It is shown that V- and Ti- ions do not completely substitute for Fe2+ ions in the LiFePO4 structure. The remaining part of these ions involve in the formation of second phase with nashiko-like structure: monoclinic Li3V2(PO4)3 (space group P21/n ) and rhombohedral LiTi2(PO4)3 (space group R-3c). According to TEM, the average size of the particle of nanocomposites is about 100-300 nm. EMF of microanalysis showed that the small particles of secondary phases are segregated at the surface of larger particles of LiFePO4. On the charge-discharge curves of LiFe0.9M0.1PO4 there are plateau corresponding to LiFePO4 and the second phase. The doping with vanadium increases the resistance of the cycling of LiFePO4 and improves its cyclability at high speeds to a greater extent than in the case of doping with titanium.
Oxygen non-stoichiometry and defect structure of LaMn1-zCuzO3+δ
Authors: Zuev A. Yu. , Tsvetkov D. S.
Published: December 2015

The quantitative model analysis of the defect structure of copper doped lanthanum manganites LaMn1-zCuzO3+δ (z = 0.05 and 0.1) was performed. In the framework of the model, the independent course of the three reactions of defect formation, including the electronic exchange between manganese and copper, completion of a lattice by the absorption of oxygen and the disproportionation of manganese was considered. It is shown that the increase in the dopant content leads to a change in the dominant electronic process. This is reflected in the lock and disproportionation and leads to the increase in the concentration of holes and decrease the concentration of electrons localized on the manganese atoms.
Surface reactions with participation of oxides of molybdenum and tungsten
Authors: Guseva A. F. , Trifonova M. V.
Published: December 2015

The kinetics of surface reactions in one-dimensional and radial (two-dimensional) distribution of diffusant MoO3 (WO3) on the surface of the substrate MeO (Me is Cd, Ni, Pb, Mn, Cu) were investigated. A kinetic equation satisfactorily describes the rate of surface reactions in the case of radial distribution of diffusant on the substrate. It’s found that when the radial distribution of diffusant the growth of layer on the substrate surface eventually slows down and stops almost completely, due to the outflow of the diffusant deeps into the substrate. When the one-dimensional distribution of diffusant the surface interaction is not slowed down and does not stop at an arbitrarily large times.
Racial Differences in Tobacco Cessation and Treatment Usage After Lung Screening: An Examination of the National Lung Screening Trial
Authors: Kumar Pallavi , Gareen Ilana F. , Lathan Christopher , Sicks JoRean D. , Perez Giselle K. , Hyland Kelly A. , Park Elyse R.
Published: December 2015

Background.

Black smokers have demonstrated greater lung cancer disease burden and poorer smoking cessation outcomes compared with whites. Lung cancer screening represents a unique opportunity to promote cessation among smokers; however, little is known about the differential impact of screening on smoking behaviors among black and white smokers. Using data from the National Lung Screening Trial (NLST), we examined the racial differences in smoking behaviors after screening.

Methods.

We examined racial differences in smoking behavior and cessation activity among 6,316 white and 497 black (median age, 60 and 59 years, respectively) NLST participants who were current smokers at screening using a follow-up survey on 24-hour and 7-day quit attempts, 6-month continuous abstinence, and the use of smoking cessation programs and aids at 12 months after screening. Using multiple regression analyses, we examined the predictors of 24-hour and 7-day quit attempts and 6-month continuous abstinence.

Results.

At 12 months after screening, blacks were more likely to report a 24-hour (52.7% vs. 41.2%, p < .0001) or 7-day (33.6% vs. 27.2%, p = .002) quit attempt. However, no significant racial differences were found in 6-month continuous abstinence (5.6% blacks vs. 7.2% whites). In multiple regression, black race was predictive of a higher likelihood of a 24-hour (odds ratio [OR], 1.6, 95% confidence interval [CI], 1.2–2.0) and 7-day (OR, 1.5, 95% CI, 1.1–1.8) quit attempt; however, race was not associated with 6-month continuous abstinence. Only a positive screening result for lung cancer was significantly predictive of successful 6-month continuous abstinence (OR, 2.3, 95% CI, 1.8–2.9).

Conclusion.

Although blacks were more likely than whites to have 24-hour and 7-day quit attempts, the rates of 6-month continuous abstinence did not differ. Targeted interventions are needed at the time of lung cancer screening to promote abstinence among all smokers.
Transcription Factor Hepatocyte Nuclear Factor–1β Regulates Renal Cholesterol Metabolism
Authors: Aboudehen Karam , Kim Min Soo , Mitsche Matthew , Garland Kristina , Anderson Norma , Noureddine Lama , Pontoglio Marco , Patel Vishal , Xie Yang , DeBose-Boyd Russell , Igarashi Peter
Published: December 2015

HNF-1β is a tissue–specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, the complete spectrum of HNF-1β–regulated genes and pathways is not known. Here, using chromatin immunoprecipitation/next generation sequencing and gene expression profiling, we identified 1545 protein-coding genes that are directly regulated by HNF-1β in murine kidney epithelial cells. Pathway analysis predicted that HNF-1β regulates cholesterol metabolism. Expression of dominant negative mutant HNF-1β or kidney-specific inactivation of HNF-1β decreased the expression of genes that are essential for cholesterol synthesis, including sterol regulatory element binding factor 2 (Srebf2) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr). HNF-1β mutant cells also expressed lower levels of cholesterol biosynthetic intermediates and had a lower rate of cholesterol synthesis than control cells. Additionally, depletion of cholesterol in the culture medium mitigated the inhibitory effects of mutant HNF-1β on the proteins encoded by Srebf2 and Hmgcr, and HNF-1β directly controlled the renal epithelial expression of proprotein convertase subtilisin–like kexin type 9, a key regulator of cholesterol uptake. These findings reveal a novel role of HNF-1β in a transcriptional network that regulates intrarenal cholesterol metabolism.
Values Underlying the Information Culture in Communist and Post-Communist Russia (1917−1999)
Authors: De Smaele Hedwig
Published: December 2015

In this article the concept of information culture—understood as the dominant handling of information, shared by a dominant proportion of journalists, the public, authorities and other actors within a societal environment at a given time and place—is explored in the context of Communist and early post-Communist Russia (1917−1999). Three value pairs underlying the attitude towards information are explored: individualism and collectivism (the relation of man to the state), universalism and particularism (the relation of man to man), and pluralism versus dominance (the nature of knowledge and truth). Continuities are found between the Communist Soviet Union and post-Communist Russia in their instrumental use of media and information (collectivism), the view on information as a particular privilege rather than a universal right and the monopoly of truth. Post-Communism, therefore, appears not only as an indication of time (i.e. the period after Communism) but also as an indicator of the continuation of basic value orientations over these time periods.
Comparing Czech and Slovak Council Newspapers’ Policy and Regulation Development
Authors: Waschkova Cisarova Lenka
Published: December 2015

Council newspapers form an integral part of European media systems and, as such, have been analysed for their important contribution to the development of local politics. However, despite a recognition of the media’s important democratic function in the transition countries of Central and Eastern Europe (CEE) after the fall of socialism, the consideration of council newspapers’ political role in the Czech Republic and Slovakia have been largely absent in debates surrounding the development of regulatory frameworks until recently. Interestingly, debates regarding local government transparency emerged recently (2011) in the United Kingdom, resulting in the Code of recommended practice on local authority publicity, underscoring the importance of this issue. However, developments in the aforementioned situations demonstrate divergent outcomes in such considerations: the British addressed the causes, the Czechs addressed the symptoms, and the Slovaks have yet to make any headway. This article utilizes qualitative analysis of policy and regulation documents to compare the trajectories of media policy and regulation of council publicity in the Czech Republic and Slovakia, ultimately contrasting it with developments in the UK, suggesting possible future trajectories for the development of this type of regulation in the CEE countries.
A View from the Inside: The Dawning Of De-Westernization of CEE Media and Communication Research?
Authors: Lauk Epp
Published: December 2015

The Editorial outlines some characteristics of the development of the Central and Eastern European (CEE) media and communication scholarship during the past 25 years. In the majority of CEE countries, the media and communication research was re-established after the collapse of communism. Since then, a critical mass of active scholars has appeared who form an integral part of the larger European academia. A gradual integration of East and West perspectives in media and communication research is taking place along with moving away from the barely West-centred approach, and utilizing the research done by CEE scholars. Certain ‘de-westernization’ and internationalization of the research in terms of theoretical and methodological frameworks is depicted.
Successful treatment of early prosthetic valve endocarditis infection caused by Burkholderia cepacia: A rare case report
Authors: R Balaji , B Anil Kumar
Published: December 2015

Abstract is not available for this article
Benign cartilaginous lesions
Authors: S Kakarla
Published: December 2015

Abstract is not available for this article
Imaging in fibrous dysplasia
Authors: S Kakarla
Published: December 2015

Abstract is not available for this article
Hepatic MRI in evaluation of focal liver lesions using diffusion weighted sequence (DWI) - our initial experience
Authors: M Jwala Srikala
Published: December 2015

Abstract is not available for this article
INFRASTRUCTURE OF PROVIDING SAFETY OF THE BANKING SECTOR AND THE PROBLEM OF OVERCOMING OF THE CRISIS PHENOMENA IN ACTIVITY OF COMMERCIAL BANKS
Authors: Larionova I. V.
Published: December 2015

One of the most important problems in the conditions of the prolonged macroeconomic instability mentioning the most sensitive sector of Economics is banking sector, is development of indicators and preventive measures from the regulator and management of banks on overcoming of the becoming ripe crisis phenomena. Crises of the last years show that regulators, despite development and toughening of measures of regulatory influence and microprudential supervision, constantly are late that leads to considerable expenses of rescue of banks and payments of compensations to investors of bankrupt monetary and credit institutes. In article the most sensitive areas in regulation and financial improvement of the credit organizations are considered. The author offers to expand the list of functions of Deposit Insurance Agency by means of introduction of institute the bridge-banks and attraction of financial resources of private investors for rescue of banks. At the same time in article it is emphasized that criteria of identification of problem situations in the banking sector need development by means of introduction along with the operating indicators of signs of the advancing problems of non-financial and financial character. The formulated offers will demand specification of the legislation and regulatory base of Bank of Russia.
Universal Service in the Spotlight
Authors: Gregory Mark A
Published: December 2015

In the December issue papers cover a range of telecommunications related issues both locally and internationally, including Universal Service, legacy telecommunications equipment and a timely review of the progress of the rollout of Ultra-Fast Broadband in New Zealand. A theme in this issue focuses on Universal Service and provides discussion on what a revised Universal Service should constitute and how this revised Universal Service should be delivered. As the digital transformation of government and community service delivery progresses there is a need to consider how new and upgraded telecommunications infrastructure can be best utilised to provide Universal Service. Another theme in this issue considers how telecommunications and service providers are working to ensure that legacy telecommunications equipment is identified, upgraded where necessary and connected to the National Broadband Network or replaced. Readers will also find an interesting update on the provision of reliable telecommunications to Antarctica and how Ericsson is celebrating the milestone of being a significant contributor to Australian telecommunications over the past 125 years.
Dampak Implementasi Kurikulum PAI Terhadap Perilaku Keagamaan
Authors: Wibowo AM
Published: December 2015

This study is intended to know the impact of implementing two different
curricula in Islamic-based senior high schools in Malang, East Java. Using
two-way anova method, this study reveals three important facts. Firstly, there
is significantly different religious behaviour of pupils who are taught islamic
education curriculum from Ministry of National Education from those who
are taught based on the Islamic education curriculum “plus”. Secondly, there
is important difference on religious behaviour of students of the X, XI and XII.
The last, the implementation of islamic education in both schools which implement
Islamic education curriculum from Ministry of National Education and Islamic  education curriculum “plus” runs well. This study finally arrives at a conclusion that, in terms of religious behaviour,  students of those schools which implement curriculum “plus” are much better than those of the other category.
Pelaksanaan Pendidikan Agama Pada SD-LB B Sidakarya Kota Denpasar
Authors: Taruna Mulyani Mudis
Published: December 2015

The  Research  on the Implementation of Religious Education was conducted
at the  SD Luar Biasa Part  B (SD-LB B) Sidakarya Denpasar, Bali  Province. The
results of this study indicate that the religious education implementation at the
SD-LB B Sidakarya is still less attention. It can be seen from  the teaching materials that still use the public school textbook and there is no
RPP or specialized reference books for SD-LB B, religious teachers concerns to
 a religion teacher. The supporting factors in the process of learning  is  good  spirit for student availability of classrooms, school infrastructure and the location is not far from the student  environment.  The problem Inhibiting in the  learning    rocess is the lack of teaching tools, no specific reference books for  deaf and dumb there isnt good attantion for religioous teaching is still not getting  the attention of the series.
Persepsi Terhadap Nikah Sirri Kasus Masyarakat Desa Sinarrancang, Kecamatan Mundu, Kabupaten Cirebon
Authors: Zubir Ismail
Published: December 2015

This study aims to find out the perception of people in Sinarrancang, Mundu, Cirebon, West Java, on nikah sirri (“secret” marriage). Using qualitative approach the study reveals that in their opinion nikah sirri mean  nikah “kyai”, it is a marriage by ulama and  has become a long hereditary tradition. According to  fiqih munakahat (a branch of Islamic law which studies  about  marriage) this kind of marriage is legitimate because it meets the conditions and requirements of marriage. According to positive law, however,  such  marriage is illegal for not being registered at KUA (a governmental institution which administers Muslim marriage). In order to change their perception on nikah sirri, it needs to socialize UU No. 1 Tahun 1974 continuously. KUA’s service to people has to be addressed so that its accountability  and responsibility could run effectively; and more importantly the draft  of   Religious  Courts Law Materials that would provide punishment for those conducting nikah sirri do not contradict with Islamic law.
Makna Arsitektur Masjid Pakualaman dalam Tinjauan Kosmologi Jawa
Authors: Hasyim Moh
Published: December 2015

Masjid memiliki arti penting dalam kebudayaan dan peradaban Islam. Masjid
tidak hanya sebagai simbol kebesaran Islam tetapi juga menjadi simbol harmoni kehidupan manusia dengan alam lingkungan. Melalui  pendekatan sejarah dan arkeologi penelitian ini menemukan bahwa Masjid  Pakulaman memiliki keterkaitan dengan perkembangan kebudayaan Jawa.  Secara utuh bangunan Masjid Pakualaman merupakan perpaduan antara  unsur Hindu Jawa dan Islam sebagai bentuk yang sarat
dengan makna kosmologis dan kaya   harmonisasi kehidupan spiritual. Harmonisasi tersebut dapat dilihat dari bentuk atap tajuk dengan mustaka berbentuk gada, ornamen
sulur bunga dan gapura pintu utama.
Pelayanan KUA terhadap Persoalan Keagamaan di Kabupaten Belu
Authors: Haryanto Joko Tri
Published: December 2015

Umat Islam di wilayah yang muslim merupakan kelompok minoritas memiliki persoalan keagamaan yang berbeda dengan persoalan di wilayah mayoritas. Hal ini juga berimplikasi pada pelayanan keagamaan yang dilakukan oleh  pemerintah melalui KUA. Penelitian yang dilakukan dengan  pendekatan kualitatif ini mengungkapkan persoalan keagamaan yang dihadapi oleh umat Islam di Kabupaten Belu Nusa Tenggara Timur (NTT) dan pelayanan KUA terhadap persoalan keagamaan yang ada, di antaranya pembinaan keagamaan, konsumsi daging halal, dan  kerukunan umat beragama.   KUA di Kabupaten Belu  melakukan pelayanan baik dalam pencatatan nikah, wakaf dan haji, juga berupaya membantu umat Islam menyelesaikan persoalan keagamaan yang dihadapi meskipun terdapat berbagai  kendala baik internal maupun eksternal.
De-Radicalization of Intepretation the Concept of Nation and Jihad in Tafsir al-Azhar
Authors: Sidik Sidik
Published: December 2015

There is no a single definition of state and jihad because there has been no agreement on the terms. Therefore, there is a gap between perceived concept of state and jihad and recent de- velopment of nation-state, plurality, and civility. In additions, the emergence of psychoso- cial factor such as truth claim and the feeling of being marginalized and oppressed results in radicalism under the banner of religion. Based on the aforementioned background, this paper seeks to discuss “Tafsir al-Azhar”, a monumental work of Haji Abdul Malik Karim Amrullah (Hamka), an Indonesian leading figure in tafsir (interpretation) study. This is the first tafsir book written in Bahasa Indonesia and becomes one of the main sources in the field. By using documentation and hermeneutics the writer revealed not only the substance and the method of interpreting the concepts of “state” and “jihad”, but also their significance for the attempt of de-radicalization in Indonesia. According to Hamka, the relationship between religion and state was integral and the formation of the state de- pended on social development; whereas the concept of jihad did not merely mean “war”. In a boarder meaning, the concept of jihad included physical and non-physical dimen- sions. Physical jihad (battle) was permissible under certain conditions and circumstances.
The Relevance Concept of Dawn and Twilight in the Book of Al-Qanun al-Mas’udi for Determine Isya’ and Subuh Pray Time
Authors: Atmanto Nugroho Eko
Published: December 2015

Morning dawn and phenomenon twilight phenomenon are interesting for the sci- entists not only for weather forecast and navigation but also setting time prayer times for muslims. The concept of the morning dawn and evening twilight were introduced by al-Biruni in the book Al-Qanun al-Mas’udi. Al-Biruni described the scene at morning dawn and evening twilight in the book Al-Qanun al-Mas’udi and concluded that the twilight occur when the position of the sun is at an altitude of -18°. The concept of al-Biruni is recognized by modern science, astronomy, and the prophetic tradition for its conformity. Besides, the discovery of al-Biruni on the height of the sun is so far used by several religious organizations in some coun- tries to set the time for isha and fajr prayers. By using content analysis, this study discussed the relevance of the concept of morning dawn and evening twilight in the book Al-Qanun al-Mas’udi for determining maghrib prayer time, the praying time for isha and fajr as well.
Susceptibility of mung bean varieties to Callosobruchus chinensis under storage conditions
Authors: Parmar V. R. , Patel B. H.
Published: December 2015

Investigations were carried out during 2013 on mung bean for their susceptibility against Callosobruchus chinensis L. under storage. Among the mung bean varieties; Vishal, Samrat, GM-3, GM-4 and K-851 were found resistant based on oviposition preference (7.97/20 seeds, 8.74, 8.99, 9.17 and 9.49, respectively), population growth (345.09, 371.99, 397.50, 405.52, and 437.56, respectively), per cent weight loss (6.11%, 7.43%, 8.08%, 9.28% and 11.04%, respectively) and per cent germination loss (29.27%, 36.03%, 34.91%, 40.36% and 40.42%, respectively) against C. chinensis. Variety VMS-6 was also found resistant based on oviposition preference (9.61), population growth (437.56) and germination loss (43.87%) whereas GM-2 was resistant based on oviposition preference (10.72).