bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid detection of phenotypes Bombay sedel and nonsecretor rs200157007 SNP (302C > T) by real-time PCR-based methods
Authors: Soejima Mikiko , Koda Yoshiro
Published: July 2021

Thesedelallele is one of the nonsecretor alleles (se) ofFUT2generated by an Alu-mediated recombination event and was first found in Indian Bombay phenotype individuals who have anti-H, anti-A, and anti-B antibodies in their serum. As well as anti-A, and anti-B antibodies, anti-H is clinically significant because it causes sever hemolytic transfusion reactions. Likesedel,se302having a missense single nucleotide polymorphism (SNP), 302C > T, is characteristic of South Asians with a frequency of 10–30%. We developed a real-time PCR melting curve analysis for detection ofsedelusing a 127-bp amplicon encompassing the breakpoint junction. In addition, by performing duplex PCR by amplifying a 65-bp amplicon of theFUT2coding region at the same time, we could determine the zygosity ofsedelin a single tube. We also developed an Eprobe-mediated PCR assay (Eprobe-PCR) for detection of 302C > T ofFUT2.These methods were validated by analyzing 58 Tamils and 54 Sinhalese in Sri Lanka. Both the duplex PCR melting curve analysis for determination ofsedelzygosity and the Eprobe-PCR assay for detection of 302C > T exactly determined three genotypes. In addition, the results of the present methods were in complete agreement with those obtained by previously established methods. The two present methods were reliable and seem to be advantageous for large-scale association studies ofFUT2polymorphisms in South Asian populations.
Dynamic particle swarm optimization of biomolecular simulation parameters with flexible objective functions
Authors: Weiel Marie , Götz Markus , Klein André , Coquelin Daniel , Floca Ralf , Schug Alexander
Published: July 2021

Molecular simulations are a powerful tool to complement and interpret ambiguous experimental data on biomolecules to obtain structural models. Such data-assisted simulations often rely on parameters, the choice of which is highly non-trivial and crucial to performance. The key challenge is weighting experimental information with respect to the underlying physical model. We introduce FLAPS, a self-adapting variant of dynamic particle swarm optimization, to overcome this parameter selection problem. FLAPS is suited for the optimization of composite objective functions that depend on both the optimization parameters and additional, a priori unknown weighting parameters, which substantially influence the search-space topology. These weighting parameters are learned at runtime, yielding a dynamically evolving and iteratively refined search-space topology. As a practical example, we show how FLAPS can be used to find functional parameters for small-angle X-ray scattering-guided protein simulations.
A fluorescent aptasensor based on copper nanoclusters for optical detection of CD44 exon v10, an important isoform in metastatic breast cancer
Authors: Bahmani Amin , Shokri Ehsan , Hosseini Morteza , Hosseinkhani Saman
Published: July 2021

The aim of the current study was to develop an aptasensor based on fluorescent metal nanoclusters for early detection of cancer stem cells and metastatic breast cancer. For this the v10 isoform of CD44 was selected as a specific target.
Enhanced oxidase-mimicking activity of Ce4+ by complexing with nucleotides and its tunable activity for colorimetric detection of Fe2+
Authors: Liu Jiaojiao , Cao Ying , Zhu Xinyue , Zou Lina , Li Gaiping , Ye Baoxian
Published: July 2021

Colorimetric sensing of Fe2+ based on the regulation of the oxidase-mimicking activity of AMP-Ce4+ ICPs.
Nitrogen-functionalized carbon nanotube-supported bimetallic PtNi nanoparticles for hydrogen generation from hydrous hydrazine
Authors: Hu Xiaoping , Liu Tong , Zhang Xiaoli , Tian Jian
Published: July 2021

Ultrafine PtNi nanoparticles (NPs) supported on N-functionalized multi-walled carbon nanotubes (N-MWCNTs) for fast hydrogen generation from hydrous hydrazine were facilely obtained.
PtPdCu cubic nanoframes as electrocatalysts for methanol oxidation reaction
Authors: Liu Wen , Wang Peng , Wang Zhenghua
Published: July 2021

PtPdCu cubic nanoframes with unique open architecture exhibit excellent electrocatalytic performances toward methanol electrooxidation.
New complexes of liquid crystal discotic triphenylenes: induction of the double gyroid phase
Authors: Otmakhova O. A. , Piryazev A. A. , Bondarenko G. N. , Shandryuk G. A. , Maryasevskaya A. V. , Merekalov A. S. , Ivanov D. A. , Talroze R. V.
Published: July 2021

Hypothetic structures of H5T/TNF-carb (a) and TPh-3A/TNF-carb (b).
Quantum-state-dependent decay rates of electrostatically trapped Rydberg NO molecules
Authors: Rayment M. H. , Hogan S. D.
Published: July 2021

Nitric oxide molecules in high Rydberg states have been decelerated and electrostatically trapped in a chip-based Rydberg–Stark decelerator. Measured trap decay rates shed new light on slow decay processes of Rydberg states in small molecules.
Synchronization scenarios induced by delayed communication in arrays of diffusively coupled autonomous chemical oscillators
Authors: Budroni Marcello A. , Pagano Giovanni , Conte Dajana , Paternoster Beatrice , D’ambrosio Raffaele , Ristori Sandra , Abou-Hassan Ali , Rossi Federico
Published: July 2021

Delayed feedbacks in the inhibitory coupling drive the transition from anti-phase to in-phase collective synchronization in linear arrays of communicating identical Belousov–Zhabotinsky micro-oscillators.
Achieving enhanced solid-state photochromism and mechanochromism by introducing a rigid steric hindrance group
Authors: He Junzhao , Zhao Huimin , Wu Han , Yang Yuhui , Wang Zhaohui , He Zhe , Jiang Guohua
Published: July 2021

Achieving enhanced solid-state photochromism and mechanochromism by introducing a rigid steric hindrance group.
Increase in anthropogenic antibiotic resistance markers in water supplied by an overhead tank based-water distribution system
Authors: Bhaskar Deepika , Singh Gargi
Published: July 2021

The levels of anthropogenic antibiotic resistance gene markers increased in tap water supplied by an overhead tank-based water distribution system, which are popular in many low and middle-income countries.
Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota
Authors: Mu Zhiyong , Yang Yijin , Xia Yongjun , Wang Fukang , Sun Yiwei , Yang Ying , Ai Lianzhong
Published: July 2021

Saccharomyces cerevisiae BR14 with superior stress tolerance and little toxicity to RAW264.7 cells is obtained. The strain could ameliorate colitis by restoring the gut barrier and microbiota.
Design and production of environmentally degradable quaternary ammonium salts
Authors: Zhang Xiaolong , Kong Hongtao , Zhang Xuepeng , Jia Hengmin , Ma Xiuxia , Miao Hui , Mu Yan , Zhang Guoqing
Published: July 2021

Our QACs, being cost-effective and naturally degradable, have the potential to replace their currently-used more-stable counterparts as a universal active ingredient for disinfectant products.
Size distribution measurement of microplastics using a temporally and spatially resolved inductively coupled plasma optical emission spectrometer (ICP-OES)
Authors: Teramoto Yoshiyuki , Kim Hyun-Ha
Published: July 2021

We studied microplastics in water using a temporally and spatially resolved ICP-OES with an inverted-type torch.
Study of ultrasound thrombolysis using acoustic bubbles in a microfluidic device
Authors: Gao Yuan , Wu Mengren , Gaynes Bruce I. , Dieter Robert S. , Xu Jie
Published: July 2021

Thrombosis is a common medical entity associated with many forms of cardiovascular disease. In this study, we introduce a novel approach to study ultrasound thrombolysis of blood clots using an acoustic bubble-based microfluidic platform.
Magnetic AgNPs/Fe3O4@chitosan/PVA nanocatalyst for fast one-pot green synthesis of propargylamine and triazole derivatives
Authors: Ghasemi Kousar , Darroudi Mahdieh , Rahimi Marjan , Rouh Hossein , Gupta Anju R. , Cheng Chun , Amini Abbas
Published: July 2021

A new green magnetic nanocatalyst was introduced for one-pot fast synthesis of propargylamine and triazole derivatives.
NiCo LDH in situ derived NiCoP 3D nanoflowers coupled with a Cu3P p–n heterojunction for efficient hydrogen evolution
Authors: Yang Mengxue , Li Yanbing , Yan Teng , Jin Zhiliang
Published: July 2021

A p–n heterojunction of Cu3P coupling with NiCoP nanoflower has been synthesized. The heterojunction promotes the separation efficiency of photogenerated carriers and enhances photocatalytic hydrogen production activity.
Highly efficient photothermal nanoparticles for the rapid eradication of bacterial biofilms
Authors: He Wei , Wang Zaiyu , Bai Haotian , Zhao Zheng , Kwok Ryan T. K. , Lam Jacky W. Y. , Tang Ben Zhong
Published: July 2021

An effective photothermy generation aggregate system for bacterial biofilm elimination was designed and investigated. Results indicated that the biofilm matrix was destroyed by the nano-system in addition to the killing of the embedded bacteria.
The signal-to-noise issue in mass spectrometric analysis of polymers
Authors: Chagunda Ian C. , Russell Gregory T. , McIndoe J. Scott
Published: July 2021

Mass spectrometric approaches to polymer analysis become increasingly ineffective as average molecular weight increases. This perspective explains these fundamental limits of MS for determining molecular weight distribution of high polymers.
Long afterglow MOFs: a frontier study on synthesis and applications
Authors: Yuan Jiangyan , Dong Jie , Lei Shengbin , Hu Wenping
Published: July 2021

The recent advances in the fabrication and application of MOF-based long afterglow materials.
Radical cations and dications of bis[1]benzothieno[1,4]thiazine isomers
Authors: Hauer Simone T. , Schneeweis Arno P. W. , Waniek Sven D. , Sorge Lukas P. , Heinze Katja , Müller Thomas J. J.
Published: July 2021

Radical cations and dications of three isomeric bis[1]benzothieno[1,4]thiazines are (electro)chemically generated, spectroscopically characterized and assigned by (TD)DFT calculations.
The molecular imprinting of magnetic nanoparticles with boric acid affinity for the selective recognition and isolation of glycoproteins
Authors: Wang Bangjin , Duan Aihong , Xie Shengming , Zhang Junhui , Yuan Liming , Cao Qiue
Published: July 2021

A strategy was designed for the preparation of molecular imprinting of magnetic nanoparticles with boric acid affinity (MNPs@MIP), and the resultant MNPs@MIP exhibited excellent selectivity for template glycoproteins.
Design of ferrocenylseleno-dopamine derivatives to optimize the Fenton-like reaction efficiency and antitumor efficacy
Authors: Cheng Qianya , Zhou Tong , Xia Qing , Lu Xiulian , Xu Heng , Hu Ming , Jing Su
Published: July 2021

The tertiary amine in F4b facilitates the Fenton-like reaction to generate toxic ˙OH which induces apoptosis through CDK-2 inactivation.
Microbial diversity in full-scale water supply systems through sequencing technology: a review
Authors: Zhou Wei , Li Weiying , Chen Jiping , Zhou Yu , Wei Zhongqing , Gong Longcong
Published: July 2021

Drinking water microbial diversity influence in full-scale water supply systems.
Controlling hydrogel properties by tuning non-covalent interactions in a charge complementary multicomponent system
Authors: Panja Santanu , Seddon Annela , Adams Dave J.
Published: July 2021

The properties of a charge complementary multicomponent gel can be tuned either by pH change or by varying the preparative pathway.
An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation
Authors: Zha Jun , Li Jinjing , Fan Shihui , Duan Zengping , Zhao Yibing , Wu Chuanliu
Published: July 2021

A general method was developed to design multicyclic peptides with diverse disulfide frameworks amenable to random peptide library design, enabling the development of new disulfide-rich peptide ligands and therapeutics with structures not derived from natural peptides.
Molecular crystalline capsules that release their contents by light
Authors: Nagai Akira , Nishimura Ryo , Hattori Yohei , Hatano Eri , Fujimoto Ayako , Morimoto Masakazu , Yasuda Nobuhiro , Kamada Kenji , Sotome Hikaru , Miyasaka Hiroshi , Yokojima Satoshi , Nakamura Shinichiro , Uchida Kingo
Published: July 2021

A novel diarylethene formed “crystalline capsules” containing liquid inclusions, and chemicals trapped in the capsules were released by photoinduced breaking. Operations by multiphoton and linear polarized light were demonstrated.
Design of a ZnS/CdS/rGO composite nanosheet photocatalyst with multi-interface electron transfer for high conversion of CO2
Authors: Xu Mengyang , Jiang Haopeng , Li Xin , Gao Ming , Liu Qi , Wang Huiqin , Huo Pengwei , Chen Songtao
Published: July 2021

In ZnS/CdS/rGO, the photogenerated e− transfer from ZnS → CdS, CdS → rGO & ZnS → CdS → rGO, establishing multi-interface electronic transmission channels for electrons to increase the transfer & separation efficiency of photogenerated carriers in this hybrid photocatalyst.
Tailoring oxygen evolution reaction activity of metal-oxide spinel nanoparticles via judiciously regulating surface-capping polymers
Authors: Sewell Christopher D. , Wang Zewei , Harn Yeu-Wei , Liang Shuang , Gao Likun , Cui Xun , Lin Zhiqun
Published: July 2021

It is discovered that the negative effects on OER activity caused by the stabilization of NPs with surface-capping polymers can be mitigated by decreasing the grafting density or increasing the hydrophilicity of the polymer chains.
High-entropy effect of a metal phosphide on enhanced overall water splitting performance
Authors: Lai Dawei , Kang Qiaoling , Gao Feng , Lu Qingyi
Published: July 2021

High-entropy metal phosphide (HEMP) NiCoFeMnCrP nanoparticles embedded in a carbon matrix are successfully fabricated by a facile sol–gel strategy and demonstrated to have greatly enhanced catalytic activities for the OER and HER.
Carbon black nanoparticle trapping: a strategy to realize the true energy storage potential of redox-active conjugated microporous polymers
Authors: Kang Chang Wan , Ko Yoon-Joo , Lee Sang Moon , Kim Hae Jin , Choi Jaewon , Son Seung Uk
Published: July 2021

The pseudocapacitive performance of redox-active conjugated microporous polymers was enhanced through the trapping of carbon black nanoparticles.
Critical role of zeolites as H2S scavengers in argyrodite Li6PS5Cl solid electrolytes for all-solid-state batteries
Authors: Lee Donggun , Park Kern-Ho , Kim So Yeun , Jung Jae Yup , Lee Wonrak , Kim KyungSu , Jeong Goojin , Yu Ji-Sang , Choi Jungkyu , Park Min-Sik , Cho Woosuk
Published: July 2021

A composite electrode containing a zeolite (ZSM-5) embedded Li6PS5Cl solid electrolyte, where zeolite can act as a scavenger for both toxic H2S gas and moisture is designed for realizing high-performance all-solid-state batteries (ASSBs) with improved cycle performance.
Balancing crystallization rate in a mixed Sn–Pb perovskite film for efficient and stable perovskite solar cells of more than 20% efficiency
Authors: Zhang Zhanfei , Liang Jianghu , Zheng Yiting , Wu Xueyun , Wang Jianli , Huang Ying , Yang Yajuan , Zhou Zhuang , Wang Luyao , Kong Lingti , Reddy Kolan Madhav , Qin Chaochao , Chen Chun-Chao
Published: July 2021

A surface treatment of PEDOT:PSS layer with [PNA]BF4 is employed to realize vertically homogeneous distribution of Sn/Pb-containing perovskite films through balancing its crystallization rate and achieving chemical encapsulation of the acidic PEDOT:PSS substrate.
Advancements in structure–property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application
Authors: Koper Filip , Świergosz Tomasz , Żaba Anna , Flis Agata , Trávníčková Martina , Bačáková Lucie , Pamuła Elżbieta , Bogdał Dariusz , Kasprzyk Wiktor P.
Published: July 2021

Herein, a renewed prominence towards the synthesis of poly(alkylene citrate) (PAC) biomaterials and their detailed chemical, structural and mechanical characterization has been reported.
Growth of mineralized collagen films by oriented calcium fluoride nanocrystal assembly with enhanced cell proliferation
Authors: Fang Weijian , Ping Hang , Huang Ying , Xie Hao , Wang Hao , Wang Weimin , Fu Zhengyi
Published: July 2021

The intrafibrillar mineralization of collagen films with oriented calcium fluoride nanocrystals in vitro is realized. The growth process of the mineralized collagen films is revealed and they exhibit an enhanced cell proliferation.
Nanotechnology lights up the antitumor potency by combining chemotherapy with siRNA
Authors: Sun Jian , Ogunnaike Edikan Archibong , Jiang Xing , Chen Zhaowei
Published: July 2021

This review summarizes the latest nanosystems with different functional nanomaterials that co-load and protect the siRNA/drugs, precisely target tumors, and release cargoes intelligently.
Polarization engineered InGaN/GaN visible-light photodiodes featuring high responsivity, bandpass response, and high speed
Authors: Lv Zesheng , Guo Yao , Zhang Supeng , Wen Quan , Jiang Hao
Published: July 2021

InGaN/GaN visible-light p–i–n photodiodes with a p-down structure were fabricated using a polarization-doped p-type layer realized by depositing a linearly graded AlGaN. The photodiodes exhibited high responsivity, high speed and bandpass response.
Monitoring the role of site chemistry on the formation energy of perovskites via deep learning analysis of Hirshfeld surfaces
Authors: Williams Logan , Mukherjee Arpan , Dasgupta Aparajita , Rajan Krishna
Published: July 2021

Machine learning based on atomic Hirshfeld surfaces shows promise for material property prediction of diverse crystal systems.
Recent development of heavy-atom-free triplet photosensitizers: molecular structure design, photophysics and application
Authors: Zhang Xue , Wang Zhijia , Hou Yuqi , Yan Yuxin , Zhao Jianzhang , Dick Bernhard
Published: July 2021

Recent development of the heavy-atom-free triplet photosensitizers is summarized from the perspective of intersystem crossing mechanisms and molecular structure design methods.
Correction: Charge transfer doping with an organic layer to achieve a high-performance p-type WSe2 transistor
Authors: Yoon Minho , Lee Jiyoul
Published: July 2021

Correction for ‘Charge transfer doping with an organic layer to achieve a high-performance p-type WSe2 transistor’ by Minho Yoon et al., J. Mater. Chem. C, 2021, DOI: 10.1039/D1TC01780B.
Fifty years of research on the brain renin–angiotensin system: what have we learned?
Authors: Cruz-López Edwyn O. , Uijl Estrellita , Danser A.H. Jan
Published: July 2021

Although the existence of a brain renin–angiotensin system (RAS) had been proposed five decades ago, we still struggle to understand how it functions. The main reason for this is the virtual lack of renin at brain tissue sites. Moreover, although renin’s substrate, angiotensinogen, appears to be synthesized locally in the brain, brain angiotensin (Ang) II disappeared after selective silencing of hepatic angiotensinogen. This implies that brain Ang generation depends on hepatic angiotensinogen after all. Rodrigues et al. (Clin Sci (Lond) (2021) 135:1353–1367) generated a transgenic mouse model overexpressing full-length rat angiotensinogen in astrocytes, and observed massively elevated brain Ang II levels, increased sympathetic nervous activity and vasopressin, and up-regulated erythropoiesis. Yet, blood pressure and kidney function remained unaltered, and surprisingly no other Ang metabolites occurred in the brain. Circulating renin was suppressed. This commentary critically discusses these findings, concluding that apparently in the brain, overexpressed angiotensinogen can be cleaved by an unidentified non-renin enzyme, yielding Ang II directly, which then binds to Ang receptors, allowing no metabolism by angiotensinases like ACE2 and aminopeptidase A. Future studies should now unravel the identity of this non-renin enzyme, and determine whether it also contributes to Ang II generation at brain tissue sites in wildtype animals. Such studies should also re-evaluate the concept that Ang-(1-7) and Ang III, generated by ACE2 and aminopeptidase A, respectively, have important functions in the brain.
3D bioprinted and integrated platforms for cardiac tissue modeling and drug testing
Authors: Yong Uijung , Kang Byeongmin , Jang Jinah
Published: July 2021

Recent advances in biofabrication techniques, including 3D bioprinting, have allowed for the fabrication of cardiac models that are similar to the human heart in terms of their structure (e.g., volumetric scale and anatomy) and function (e.g., contractile and electrical properties). The importance of developing techniques for assessing the characteristics of 3D cardiac substitutes in real time without damaging their structures has also been emphasized. In particular, the heart has two primary mechanisms for transporting blood through the body: contractility and an electrical system based on intra and extracellular calcium ion exchange. This review introduces recent trends in 3D bioprinted cardiac tissues and the measurement of their structural, contractile, and electrical properties in real time. Cardiac models have also been regarded as alternatives to animal models as drug-testing platforms. Thus, perspectives on the convergence of 3D bioprinted cardiac tissues and their assessment for use in drug development are also presented.
Parallel‐to‐orthogonal polarisation‐state converter for dual‐mode Nd:YVO4 microchip laser
Authors: Hyodo Masaharu , Zhang Yun , Watanabe Masayoshi , Saito Shingo
Published: July 2021

Polarisation‐state conversion from parallel linear polarisation to orthogonal linear polarisation was successfully demonstrated using a birefringence crystal for the two longitudinal oscillation modes of a dual‐mode Nd:YVO4 microchip laser. The laser emitted two longitudinal oscillation modes simultaneously in the vertical linear polarisation state with a frequency difference of 101 GHz. In the experiment, it was shown that by using a 17‐mm‐long LiNbO3 birefringence crystal, it was possible to almost perfectly convert the polarisation state of the two oscillation modes by providing a π‐rad difference in phase retardations between the two oscillation modes. The residual elliptic component was eliminated using a pair of waveplates.
Structured velocity field in the inner envelope of B335: ALMA observations of rare CO isotopologues
Authors: Cabedo Victoria , Maury Anaëlle , Girart Josep M. , Padovani Marco
Published: July 2021

Context. Studies of Class 0 objects allow to characterize the dynamical processes taking place at the onset of the star formation process and to determine the physical mechanisms responsible for the outcome of the collapse. Observations of dense gas tracers allow for the characterization of key kinematics of the gas that are directly involved in the star formation process, such as infall, outflow, and rotation.

Aims. This work is aimed at investigating the molecular line velocity profiles of the Class 0 protostellar object B335 and attempts to place constraints on the infall motions happening in the circumstellar gas of the object.

Methods. We present observations of C17O (1–0), C18O (1–0), and 12CO (2–1) transitions along with an analysis of spectral profiles at envelope radii between 100 and 860 au.

Results. C17O emission presents a double-peaked line profile distributed in a complex velocity field. Both peaks present an offset of 0.2–1 km s−1 from the systemic velocity of the source in the probed area. The optical depth of the C17O emission has been estimated and found to be less than 1, suggesting that the two velocity peaks trace two distinct velocity components of the gas in the inner envelope.

Conclusions. After discarding possible motions that could produce the complex velocity pattern, such as rotation and outflow, we conclude that infall motions are responsible for producing the velocity field. Because inside-out symmetric collapse cannot explain those observed profiles, it is suggested that these are produced by non-isotropic accretion from the envelope into the central source along the outflow cavity walls.
Combining white light and UV Lyman-αcoronagraphic images to determine the solar wind speed
Authors: Bemporad A. , Giordano S. , Zangrilli L. , Frassati F.
Published: July 2021

Context.The availability of multi-channel coronagraphic images in different wavelength intervals acquired from the space will provide a new view of the solar corona, allowing us to investigate the 2D distribution and time evolution of many plasma physical parameters, such as plasma density, temperature, and outflow speed.

Aims.This work focuses on the combination of white light (WL) and UV (Lyα) coronagraphic images to demonstrate the capability of measuring the solar wind speed in the inner corona directly with the ratio of these two images (a technique called the quick inversion method), thus avoiding having to account for the line-of-sight (LOS) integration effects in the inversion of data.

Methods.After a derivation of the theoretical basis and illustration of the main hypotheses in the quick inversion method, the data inversion technique is tested first with 1D radial analytic profiles and then with 3D numerical MHD simulations in order to show the effects of variabilities related to different phases of the solar activity cycle and the complex LOS distribution of plasma parameters. The same technique is also applied to average WL and UV images obtained from real data acquired by the SOHO UVCS and LASCO instruments around the minimum and maximum of the solar activity cycle.

Results.Comparisons between input and output velocities show a good agreement overall, demonstrating that this method, which allowed us to infer the solar wind speed with the WL-to-UV image ratio, can be complementary to more complex techniques requiring the full LOS integration. The analysis described here also allowed us to quantify the possible errors in the outflow speed, and to identify the coronal regions where the quick inversion method performs at the best. The quick inversion applied to real UVCS and LASCO data also allowed us to reconstruct the typical bimodal distribution of fast and slow wind at solar minimum, and to derive a more complex picture around the solar maximum.

Conclusions.The application of the technique shown here will be very important for the future analyses of data acquired with multi-channel WL and UV (Lyα) coronagraphs, such as Metis on board the Solar Orbiter, LST on board ASO-S, and any other future WL and UV Lyαmulti-channel coronagraphs.
Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced hepatocellular carcinoma
Authors: Blackstock Arthur W. , Benson Al B. , Kudo Masatoshi , Jimenez Hugo , Achari Preeya F. , McGrath Callum , Kirchner Volker , Wagner Lynne I. , O’Connell Nathaniel S. , Walker Kathy , Pasche Valerie K. , D’Agostino Ralph , Barbault Alexandre , Pasche Boris
Published: July 2021

Importance: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite the recent approval of several new agents, long-term disease control remains elusive for most patients. Administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF) by means of a spoon-shaped antenna (TheraBionic P1 device) placed on the anterior part of the tongue results in systemic delivery of low and safe levels of RF EMF from head to toe.

Objective: To report treatment outcomes and adverse events associated with treatment with the TheraBionic P1 device in comparison to suitable historical placebo and actively treated controls.

Design: Pooled case series with comparison to historical controls.

Participants: Patients with advanced HCC receiving this treatment, 18 real-world patients and 41 patients from a previously reported phase II study. Historical controls from previously conducted clinical trials.

Interventions: Three hours daily treatment with the TheraBionic P1 device compared with standard of care as received by historical controls in the previously conducted trials.

Main outcomes and measures: Overall survival (OS), time to progression, response rate, and adverse events in the combined pooled patients and in appropriate subgroups comparable to the historical control groups.

Results: In the pooled treatment group, median OS of patients with Child-Pugh A disease (n = 32) was 10.36 (95% CI 5.42–14.07) months, 4.44 (95% CI 1.64–7.13) months for patients with Child-Pugh B disease (n = 25), and 1.99 (95% CI 0.76–3.22) months for patients with Child-Pugh C disease (n = 2). Median OS for Child-Pugh A patients was 2.62 (33.9%) months longer than the 7.74 months OS of comparable historical controls (p = 0.036). The 4.73 (95% CI 1.18–8.28) months median OS for Child-Pugh B patients receiving TheraBionic P1 device as first line therapy is slightly higher than the 4.6 months median OS of historical controls receiving Sorafenib as first line therapy. Only grade 1 mucositis and fatigue were reported by patients using the device, even among Child-Pugh B and C patients. No patients discontinued treatment because of adverse events.

Conclusions and Relevance: Treatment of advanced HCC with the TheraBionic P1 device is well tolerated, even in patients with severely impaired liver function, and results in improved overall survival compared to historical controls without any significant adverse events, even after many years of continuous treatment. This treatment modality appears to be well suited for patients who have failed or are intolerant to currently approved therapies.
Application of modern ASUDD solutions on the example of Shchors street, Belgorod
Authors: Zagorodniy Nikolay , Borovskoy Alexey , Borovskaya Olga , Novopisny Evgeny
Published: July 2021

the application of modern ASUDD solutions is considered on the example of Shchors Street in Belgorod. Field studies of traffic flows were carried out. When modeling the considered area, an increase in the load was revealed. A traffic light layout plan has been developed. It is established that due to the control of the traffic flow in the lanes with the help of ASUDD solutions, the redistribution of traffic flows in the directions is achieved.
Blockchain in air cargo: challenges of new World
Authors: Poleshkina Irina
Published: July 2021

The last years’ experience of functioning during the COVID-19 pandemic has shown that digital solutions can significantly increase the efficiency of business operational processes. This study focuses on the implementation of digital technologies at the airports to optimize information and financial flows, that are required for the air cargo transportation. The study was carried out based on the analysis of technological schedules of airports and airlines for cargo handling. As a result of this study, we have identified the main problematic operations leading to an increase in the time spent by cargo at the airports. The article examines and summarizes the world practice of using blockchain technology to manage information and financial flows in air cargo. The article has developed a model for the implementation of these technologies in the air cargo industry on the basis of a single blockchain platform. This model allows making optimal use of available airport resources in order to minimize service delays. It solves the main problem of creating the transparency of the information exchange between all air cargo transportation participants.
Assessment of car engineering servicing quality based on failure information
Authors: Makarova Anna , Zakharov Nikolay , Abakumov Georgy , Elesin Sergey
Published: July 2021

The article deals with the problem of assessing car engineering servicing quality, the relevance of which increases due to the increase in the level of motorization, risk of road accidents and environmental pollution. The existing methods of assessing car engineering servicing quality are considered. A new indicator for assessing engineering servicing quality is proposed, which is equal to the ratio of failure probability increments before and after engineering servicing. An example of calculation of the proposed indicator for a group of 867 Honda CR-V cars is presented.
Distributed computing system for creating digital portraits of complex systems
Authors: Starostin Igor , Khalyutin Sergey , Pavlova Victoria , Punt Elena
Published: July 2021

Various methods of operation of complex transport systems imply knowledge of mathematical models of their components. To obtain adequate models of such components, it is necessary to take into account the physical and chemical processes occurring in them. Previously, the authors developed a potential-flow method within the framework of modern nonequilibrium thermodynamics – a unified approach to the analysis and modeling of processes of various physical and chemical nature. In accordance with this approach, as well as with the methods of mechanics, the theory of electric and magnetic circuits, electrodynamics, etc., state functions for the properties of substances and the processes under consideration are set up to the experimentally studied constant coefficients. The system of equations of the considered processes dynamics is obtained from the given state functions. The desired model (digital portrait) of the considered component is constructed by numerical-analytical transformation of the dynamic equations system based on the use of experimental data. The need to automate the proposed method of obtaining digital portraits is due to its complexity and the need to process a large amount of data. An information and computing system is proposed, which implies the construction of a block diagram of the processes in the component under consideration (model-oriented approach). Modeling these processes using a block diagram at different values of unknown parameters allows us to approximate the model (digital portrait) a component based on the resulting set of output characteristic dynamics using machine learning libraries. Process modeling and further approximation of the model is parallelized. This paper is devoted to a distributed information-computing system that implements the creation of various complex systems digital portraits.
The innovative technologists and formation of the technical operation system of civil aircraft avionics
Authors: Kuznetsov Sergey
Published: July 2021

The system of technical operation (TO) of on-board equipment or avionics of aircraft (AC) as an object of research is a set of objects and means of technical operation, maintenance and repair programs, as well as personnel performing procedures and organizing the processes of TO. The quality of the TO system is manifested in the TO process - a set of processes of intended use, operational control, maintenance, restoration and repair. The TO process, as a process of changing the TO states, can be considered as a controlled random process, determined on the set of operation states by probabilistic characteristics. The quality of the TO system is characterized by a set of properties that determine its ability to satisfy with the maximum economic efficiency the needs of the TO system of the aircraft, while ensuring the required levels of reliability and readiness of the avionics for operation. That is, the TO system has all the features inherent in complex technical systems - a hierarchical ramified structure, subordination of goals and restrictions, wide interrelationships in the process of functioning. The main research apparatus in solving problems of optimization of processes and synthesis of TO systems is the apparatus of the theory of mathematical modeling of complex technical systems, based on a system approach, the integration of analytical and simulation modeling. The article solves the problem of determining the values of the parameters of the TO system such that the costs of the system during the TO process reach a minimum when all the required tasks are completed and all restrictions on the system’s own parameters and indicators of its technical efficiency are met.
Dependences of the warm-up time changes of catalytic converters in the open storage car conditions
Authors: Zaloznov Alexei , Pevnev Nikolay , Trofimova Liudmila
Published: July 2021

In the article, emphasis made on determining the start operation time of catalytic converter in the open storage car conditions. In this regard, experiments made on author’s experimental setup, quantity of which provides a confidence probability 0,95. Results of experiments allow us to determine the dependences of the warm-up time changes of catalytic converters when the ambient temperature changes from +1°С to -30°С. The compliance with current regulatory requirements for content of CO and CH in engine exhaust provided.
Improvement of maintenance and repair system of internal combustion engines of automotive equipment
Authors: Savin Leonid , Stetsenko Alexander , Panyushkin Vladimir
Published: July 2021

The paper analyzes the operating conditions of road transport affecting its reliability. It is concluded that it is necessary to develop scientifically based strategies flexible of AE maintenance based on predicting the failure moment by extrapolating the process of time drift of the informative parameters of the AE at the interval of its intended use. To solve this problem, we propose an approach based on the use of quasi-deterministic models of the time drift of the AE parameters, which allow to obtain analytical expressions for the main reliability indicators -density of the distribution time to failure and the probability of failure -free operation at a given time interval. On the basis of these indicators of reliability in operation, performance indicators have been formed allowing determining of the optimal maintenance frequency. In the final part of the article, the author proposes an algorithm and a methodology that allows organizing flexible strategies for AE maintenance, considering special conditions of its operation.
Prävention von Konflikten und Gewalt im Akutsetting
Authors: Marie van der Made Ricarda Corinna
Published: July 2021

Damit das Personal auf akutpsychiatrischen Stationen Konflikte positiv beeinflussen und im besten Fall verhindern kann, muss es wissen, wie herausfordernde Situationen entstehen und welche Interventionen es gibt. Das Safewards-Modell bietet hier eine gute Grundlage.
Innovation und Komplexität in der Pflege
Authors: Wolf Erik , Balzer Sabine
Published: July 2021

Um sich den Herausforderungen des Gesundheitswesens und der Profession Pflege zu stellen, wurde am kbo-Inn-Salzach-Klinikum in Wasserburg am Inn das Projekt „Steuerung von Innovationen und Komplexität in der Pflege durch einen mehrstufig-integrativen Ansatz“ (kurz: StIKmA) initiiert. Ziel ist, die wissenschaftlichen Kompetenzen der Pflegestudierenden und Bachelorabsolventen gezielt einzusetzen und somit die Pflegequalität zu steigern und weiterzuentwickeln. Das Besondere ist die enge Verzahnung mit der Berufsfachschule und die Integration der Studierenden während der Ausbildung.
Ernährungsmanagement in der Psychiatrie
Authors: Schmidt Simone
Published: July 2021

Manche Menschen mit psychischen Erkrankungen leiden zusätzlich unter Mangelernährung oder Essstörungen. Hier spielt das Ernährungsmanagement eine wichtige Rolle, zumal es erheblichen Einfluss auf die Lebensqualität, Genesung, Interaktion und Autonomie hat. Wie Menschen mit Ernährungsproblemen durch ein Risiko-Screening identifiziert werden und welche allgemeinen und speziellen pflegerischen Maßnahmen es gibt, erläutern wir im Interventionskoffer.
An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs
Authors: Beste Christian , Stock Ann-Kathrin , Colzato Lorenza , Zhang Wenxin , Walter Henrik
Published: July 2021

Depression is the leading cause of disability worldwide, making antidepressant drugs the most used psychiatric drugs in the USA. Withdrawal effects and rebound symptoms frequently occur after the reduction and/or discontinuation of these drugs. Although these phenomena have been investigated with respect to the clinical symptomatology, no studies have systematically investigated the effects of withdrawal/rebound on general cognition. We present a novel framework based on the idea of allostatic adaptation, which allows to predict how different antidepressants likely impair different cognitive processes as a result of withdrawal and rebound effects. This framework relies on the assumptions that the type of cognitive impairments evoked by an antidepressant is determined by the targeted neurotransmitter systems, while the severity of deficits depends on its half-life. Our model predicts that the severity of detrimental cognitive withdrawal and rebound effects increases with a shorter half-life of the discontinued antidepressant drug. It further proposes drug-specific effects: antidepressants mainly targeting serotonin should primarily impair aversive and emotional processing, those targeting norepinephrine should impair the processing of alerting signals, those targeting dopamine should impair motivational processes and reward processing, and those targeting acetylcholine should impair spatial learning and memory. We hope that this framework will motivate further research to better understand and explain cognitive changes as a consequence of antidepressant discontinuation.
Synthesis, Antimicrobial Evaluation of Substituted Indole and
Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal
Complexes
Authors: Sharma Preeti , Singh Varun Kumar , Kumar Gajendra
Published: July 2021

Schiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine
was synthesized by the condensation of
1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at
70 oC. The prepared Schiff base ligand doped with
Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as
[M(C34H32N8O4)X]X2.
The complexes have been characterized with the help of elemental analysis,
conductance measurements, magnetic measurements and their structural
configuration have been determined by various spectroscopic (electronic, IR,
1H NMR, 13C NMR, GCMS) techniques. Electronic and
magnetic moments of the complexes indicate that the geometry of the metal center
was five coordinate square pyramidal. These metal complexes were also tested for
their antimicrobial activities to assess their inhibiting potential against
Staphylococcus aureus, Bacillus subtilis (positive bacteria) and
Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi
(negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium
sp.
[Cr(C34H32N8O4)OAc](OAc)2
shows best antimicrobial activity against all the pathogens.
Diagnostic accuracy of a novel artificial intelligence system for adenoma detection in daily practice: a prospective nonrandomized comparative study
Authors: Zippelius Carolin , Alqahtani Saleh A. , Schedel Jörg , Brookman-Amissah Dominic , Muehlenberg Klaus , Federle Christoph , Salzberger Andrea , Schorr Wolfgang , Pech Oliver
Published: July 2021

Background Adenoma detection rate (ADR) varies significantly between endoscopists, with adenoma miss rates (AMRs) up to 26 %. Artificial intelligence (AI) systems may improve endoscopy quality and reduce the rate of interval cancer. We evaluated the efficacy of an AI system in real-time colonoscopy and its influence on AMR and ADR.

Methods This prospective, nonrandomized, comparative study analyzed patients undergoing diagnostic colonoscopy at a single endoscopy center in Germany from June to October 2020. Every patient was examined concurrently by an endoscopist and AI using two opposing screens. The AI system, overseen by a second observer, was not visible to the endoscopist. AMR was the primary outcome. Both methods were compared using McNemar test.

Results 150 patients were included (mean age 65 years [standard deviation 14]; 69 women). There was no significant or clinically relevant difference (P = 0.75) in AMR between the AI system (6/197, 3.0 %; 95 % confidence interval [CI] 1.1–6.5) and routine colonoscopy (4/197, 2.0 %; 95 %CI 0.6–5.1). The polyp miss rate of the AI system (14/311, 4.5 %; 95 %CI 2.5–7.4) was not significantly different (P = 0.72) from routine colonoscopy (17/311, 5.5 %; 95 %CI 3.2–8.6). There was no significant difference (P = 0.50) in ADR between routine colonoscopy (78/150, 52.0 %; 95 %CI 43.7–60.2) and the AI system (76/150, 50.7 %; 95 %CI 42.4–58.9). Routine colonoscopy detected adenomas in two patients that were missed by the AI system.

Conclusion The AI system performance was comparable to that of experienced endoscopists during real-time colonoscopy with similar high ADR (> 50 %).
A Rare Anatomical Variation in the Pedicle of Anterolateral Thigh (ALT) Flap
Authors: Mishra Jiten Kumar , Sahu Shamendra Anand
Published: July 2021

Free anterolateral thigh (ALT) flap finds its place in the front row among the soft-tissue flaps used for complex reconstruction of various defects. Its versatile tissue component and ease of harvesting with minimal donor site morbidity made it a popular flap. However, its variable vascular anatomy alerts the reconstructive surgeon to remain aware of the common variation and vigilant with regard to unusual variation. Commonly described variations are about the origin and course of pedicle and perforators. There are rare reports regarding the presence of double arteries and single vein in the flap pedicle. Here, the authors describe these unusual anatomical variations in the pedicle of ALT flap, with two arteries and one vein, and discuss the surgical implication of the same.
Outcome of Surgical Management of Sacrococcygeal Pilonidal Sinus Disease with Rotation Flap in 52 Patients—A Retrospective Study
Authors: Mistry Abbas , Shaikh Parvez , Mohammed Aizaz , Bagasrawala Samir , Chauhan Ankit , Anthony George
Published: July 2021

Background Surgical treatment of sacrococcygeal pilonidal sinus disease (SPSD) consists of radical excision of the entire tract and treatment of the resultant raw area. Here, the authors have reviewed the results of the rotation flap for closure of the SPSD.

Aim This study aims to evaluate the outcomes following SPSD excision and rotation flap closure.

Materials and Methods All patients were treated for SPSD with excision and closure using a rotation flap from January 2010 to September 2018. Cases having a follow-up of at least 6 months post surgery were evaluated.

Result A total of 52 patients were included in the study; 42 cases were of primary disease while 10 were of recurrent disease. The patients’ follow-up records on the 3rd day, 10th day, 1 month, and 6 months were evaluated.

None of the patients showed any signs of recurrence on follow-ups. One patient developed a hematoma on the third day post surgery which was treated conservatively. One patient developed a seroma in the perianal region on the fifth postoperative day which required aspiration. Both these patients healed well subsequently.

Conclusion Rotation flap is a (simple and reliable) treatment option for closure of postexcision SPSD defect. It not only takes the tension away from suture line, but also pushes the gluteal fat from the sides into the midline, obliterating the deep crevice of the natal cleft which is believed to be one of the important factors in the causation of SPSD, thus minimizing recurrence.