bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Quality Criteria for Optimization of Chromatographic Multicomponent Separations
Authors: Yang Jyisy , Chen Yi‐Fen
Published: May 2015

This study presents a Chromatographic Optimization Function (COF) to optimize chromatographic separation conditions. The COF proposed herein provides several advantages over conventional COFs, including the ability to eliminate the ambiguous selection of the weighting factors and easily obtain the acceptable or maximum resolution in the shortest separation time. The parameters used to construct this COF are in the form of sigmoidal functions to reduce the weight of the response for less acceptable conditions and to filter out undesired situations. In addition, resolution between peaks, length of separation time, and number of peaks separated are used as parameters for constructing the proposed COF. Closely examining the performance of the COF for both simulated and experimental chromatographic separations reveals an adequate correlation with human judgment and, also, creates no problems in selecting weighting factors.
Electrocatalytic Reactions by an Iron Porphyrin/Polypyrrole Modified Electrode Monitored by Electrochemical Quartz Crystal Microbalance
Authors: Liu Mao‐Huang , Oliver Su Y.
Published: May 2015

Electropolymerization of pyrrole in aqueous solution is monitored by electrochemical quartz crystal microbalance (EQCM) during potential scan. The film formation process on the electrode is reflected by the frequency decrease for the quartz oscillator as a function of time. The film growth rate is greatly enhanced in the presence of iron(III) meso‐tetrakis(3‐sulfonatomesityl)porphyrin, which carries 3‐ of charge. The metalloporphyrin is trapped and remains intact in the polypyrrole films. The ion transport property through the iron porphyrin/polypyrrole film is the reverse of that for pure polypyrrole. Electroreduction of dioxygen and electrooxidation of alkenes are parallel to those in the solution state.
Direct Solid Phase Synthesis of Biologically Active Peptide Alcohols
Authors: Wu Ying‐Ta , Hsieh Hsing‐Pang , Chen Shui‐Tein , Wang Kung‐Tsung
Published: May 2015

New procedures have been developed for the synthesis of peptide alcohols, such as octreotide conjugates, fragment of gramicidin, and fragment of Trichorzianines in high yield using dihydropyran‐2‐carboxylic acid as a bifunctional linker to anchor Fmoc‐threoninol(But), Fmoc‐glycinol, and Fmoc‐phenylalaninol onto amine‐resins. The linker is stable during peptide elongation as evidenced by a high yield at each coupling step. The octreotide disulfide bonds were formed on‐resin by incubating the elongated octreotide/resin with Tl(TFA)3/DMF at 0 °C for 1 hour. Tl(TFA)3/DMF is sufficiently mild that the protecting group and the linker remain intact and allow further the direct coupling of conjugates to octreotide using an autosynthesizer.
Kinetic Study of the Isotope Exchange Reactions of Malonic Acid and Malonate Ion Using 1H NMR Spectroscopy. Inhibition of Acid and Base
Authors: Hsu Ming‐Ching , Jwo Jing‐Jer
Published: May 2015

The isotope exchange reactions of malonic acid and a malonate ion were investigated in acidic and basic D2O solutions, respectively, using 1H NMR spectroscopy. The isotope exchange reaction of malonic acid is inhibited by the presence of DNO3 (0–3 M) and DSO4− ion (0–0.1 M), whereas it is catalyzed by the presence of DSO4− ion (> 0.2 M), D3PO4, D2PO4− ion or DPO42– ion. The order of relative reactivity for catalyzing the isotope reaction of malonic acid in D2O is DPO42– > D2PO4− > D3PO4 > DSO4− > DNO3. The rate of the isotope exchange reaction of malonate ion in D2O decreases to a minimum and then increases with increased [NaOD]0. The mechanism of the isotope exchange reaction of malonic acid in acidic D2O is different from the general acid‐catalyzed mechanism generally observed for organic acids like acetic and dichloroacetic acids. The bimalonate ion plays an important role in the isotope exchange reactions of this system.
Synthesis, Crystal Structure and Electrochemical Behavior of a Fe(II) Complex of 8‐Mercaptoquinoline (Hmtq) with Trimethylphosphite Participation
Authors: Tong Ye‐Xiang , Kang Bei‐Sheng , Chen Xiao‐Ming , Yu Xiao‐Lan
Published: May 2015

The mononuclear complex Fe(II)(mtq)2{P(OCH3)3}2 (Hmtq = 8‐Mercaptoquinoline) with mixed N‐heterocyclic thiolato and phosphite ligands was synthesized and characterized by X‐ray crystallography and cyclic voltammetric measurement. The title complex crystallizes in the triclinic space group P‐1 with a = 8.929(4), b = 9.965(3), c = 16.913(11) Å, α = 76.21(10), β = 80.89(10), γ= 68.010(10)°, V = 1351.2(11) Å3. The Fe(II) atom exhibits an elongated octahedral geometry composed of N2S2P2 donors. The equatorial plane is made up of two cis‐oriented N donors from the thiolato ligands and two cis‐oriented monodentate P(OCH3)3 ligands. The apical sites are occupied by two trans‐oriented S atoms from the mtq− ligands. The thione form is predominant coordination mode of 8‐mercaptoquinoline with the N and S donors bound to the Fe(II) to form five‐membered chelate rings. The structural feature of the mononuclear Fe(II) complex with mixed phosphite and thiolate ligands is summarized.
Synthesis of PrBa2Cu4O8 by Solution Method under Ambient Oxygen Pressure
Authors: Huang J. C. , Cheng C. H. , Chen Y. F. , Sheen S.R. , Lee Z. L. , Shao H. Y. , Wu M. K.
Published: May 2015

A highly homogeneous and nearly monophasic PrBa2Cu4O8 compound has been synthesized at 1 atm of oxygen via a route employing polymeric ethylenediamine/citric acid precursors. The PrBa2Cu4O8 compound with a trace amount of BaCuO2 was synthesized for the first time by sintering the pellets at the temperature of 875 °C under ambient oxygen pressure. The temperature coefficient of the resistivity is positive below 190 K while above 190 K is negative. The superconducting transition was not detected down to 4.2 K. Samples were characterized by X‐ray diffraction, scanning electron microscopy, thermal analysis, and transport and magnetic measurements.
Studies on the Synthesis, Crystal Structure and Antitumor Activities of Mn(II) Complex Derived from the Desulfurization of N‐(p‐nitrophenyl)‐N′‐(methoxycarbonyl)thiourea and o‐Phenanthroline
Authors: Shen Xu , Shan Jun , Sun Hong‐Bao , Kang Bei‐Sheng
Published: May 2015

One new Mn(II) complex, 1, MnL2(phen)2 (L = p‐nitrophenylcyanamido‐N, phen = o‐phenanthroline) has been synthesized and crystallographically characterized. Complex 1 was obtained from the desulfurization and hydrolysis of H2pmt (H2pmt = N‐(p‐nitrophenyl)‐N′‐(methoxycarbonyl)thiourea) in alkaline media. 1 crystallized in the triclinic space group P‐1 with a = 11.0320(3), b = 11.7831(4), c = 12.9288(4) Å; α = 87.3590(10), β = 81.7500(10), γ= 84.0080(10)°. Preliminary pharmacological tests showed that complex 1 exhibited definite inhibition activities against human ovary tumor 3A0 and mice P388 in vitro.
Isocalamenenes from the Liverwort Bazzania tridens
Authors: Chang Ran‐Chien , Wu Chia‐Li
Published: May 2015

Four new sesquiterpenoids, 1,4‐trans‐6‐hydroxyisocalamenene; 1,4‐trans‐6‐methoxyisocalamenene; (+)‐aristol‐9‐en‐ 12β‐ol, and eudesm‐4(15)‐en‐6β‐acetoxy‐7β‐ol, were isolated from Bazzania tridens, a liverwort species. Their structures were identified by means of spectroscopic methods. The two isocalamenenes are derived from a methyl rearrangement of the calamenene skeleton.
New Sesquiterpenes from a Taiwanese Marine Sponge of the Genus Parahigginsia
Authors: Shen Ya‐Ching , Chen Chin‐Yeu , Dun Chang‐Yin
Published: May 2015

An undescribed Taiwanese marine sponge of the genus Parahigginsia yielded two new sesquiterpene hydrocarbons‐parahigginine (1) and parahigginone (2). The structures of the new compounds were established on the basis of NMR spectroscopic and mass spectrometric data. Compounds 1 and 2 exhibited moderate cytotoxicity against murine P‐388 and human KB‐16, A‐549, and HT‐29 tumor cells.
Synthesis of Pyrrolidine Derivatives by the Palladium‐Catalyzed Cyclization of N‐(2‐Cyclohexenyl)bromoacetamide Derivatives
Authors: Yang Shyh‐Chyun , Tseng Fu‐Hsiung , Hung Chung‐Wei
Published: May 2015

N‐(2‐Cyclohexenyl)bromoacetamide derivatives underwent intramolecular cyclization to give pyrrolidine derivatives in the presence of a base and a catalytic amount of palladium catalyst.
Studies of an Alkaline Activated Glassy Carbon Electrode on the Determination of Purines and DNA
Authors: Tang Tzyh‐Chyang , Huang Hsuan‐Jung
Published: May 2015

Performance of glassy carbon electrode on the determination of purines and DNA was found to be improved dramatically by activating the GCE with a simple but effective electrochemical pretreatment. Characteristics such as lowering of oxidation potential, enhancement of peak current and elimination of fouling effect were found for the activated GCE. By flow injection analysis, good reproducibility with relative standard deviations of 0.59 and 2.01% (n = 11) and rather low detection limits of 0.6 + 0.1 and 3.0 ± 0.4 nM can be obtained for the analysis of guanine and adenine. Solutions of denatured calf thymus DNA were analyzed by differential pulse voltammetry with the activated GCE. Good agreement between the obtained results and the known values confirms the feasibility of the activated GCE for DNA analysis.
Design and Synthesis of Carbohydrate Mimetics: A New Strategy for Tackling the Problem of Carbohydrate‐Mediated Biological Recognition
Authors: Wong Chi‐Huey
Published: May 2015

Carbohydrates have been known as poor candidates for drug development. Recent studies have, however, shown that structurally simplified small molecules as mimics of complex carbohydrates recognized by receptors can be developed as inhibitors of carbohydrate‐mediated biological recognition. In addition, small molecules with higher affinity and specificity than the parent ligands can be developed by incorporating additional hydrophobic or charged groups in the carbohydrate mimetic which contains essential functional groups for receptor binding. Representative examples are illustrated in the studies of sialyl Lewis x ‐ selectin interactions, glycosidase and glycosyltransferase reactions and aminoglycoside antibiotic ‐ RNA interactions.
Chiral Ruthenium‐Oxo Complexes for Enantioselective Epoxidation of trans‐Stilbene
Authors: Yu Wing‐Yiu , Fung Wai‐Hong , Zhu Jia‐Ling , Cheung Kung‐Kai , Ho Kwok‐Keung , Che Chi‐Ming
Published: May 2015

Two oxoruthenium(IV) complexes containing C2 symmetric 1,1′‐biisoquinoline (biqn) and (R,R)‐3,3′‐(1,2‐dimethylethylenedioxy)‐2,2′‐bipyridine (diopy*) were prepared, and both are active oxidants for alkene epoxidations. The oxidation of styrene and cis‐ and trans‐β‐methylstyrenes by [(Cn)(diopy*)‐RuIV(O)](ClO4)2 did not proceed enantioselectively, but the same oxidant can attain a moderate enantioselectivity of 33%ee for the trans‐stilbene oxidation to trans‐stilbene oxide. A head‐on approach model, where the C=C is directed from the top to the O=Ru moiety, is proposed to account for the facial differentiation of the trans‐stilbene oxidation.
Microwave‐Assisted Solid Reaction: Reduction of Ketones Using Sodium Borohydride
Authors: Chen Same‐Ting , Yu Hui‐Ming , Chen Shui‐Tein , Wang Kung‐Tsung
Published: May 2015

A general and efficient procedure for microwave‐assisted reduction of liquid and solid ketones using sodium borohydride without solvents is described. The added support can enhance both the efficiency and chemoselectivity of reduction.
Velocity Mapping Studies of Vibrational Energy Disposal Following Methyl Iodide Photodissociation
Authors: Parker David H. , Kitsopolous Theofanis
Published: May 2015

In this paper previous results are compared for two different types of velocity mapping studies which probe vibrational energy disposal following the A‐band photodissociation of methyl iodide, CH3I + hv → CH3 (v) + 1(2P3/2), 1*(2P1/2). Full three‐dimensional state‐specific speed and angular distributions of the nascent fragments have been recorded for the photoelectrons, iodine atoms, and methyl radicals, using state‐ and mass‐selective (2+1) resonance‐enhanced multi‐photon ionization (REMPI)/time‐of‐flight spectrometry. Two sources of information on the vibrational energy disposal are available from velocity mapping: (a) the photoelectron images, which give information on the initial stages of vibrational excitation in electronically excited CH3I, and (b) methyl radical images, which indicate the final energy disposal channels. Even though the two signals are believed to probe very different time‐scales of the dissociation process, good agreement between the two is found for the vibrational energy disposal trends. Several trends found in the data for methyl iodide photodissociation indicate that readjustment of the ab initio multi‐dimensional potential energy surfaces calculated for this molecule appears to be needed.
Determination of Stability Constants of Metal Complexes by Capillary Electrophoresis
Authors: Allen Chang C. , Chen Chang‐Yuh , Chen Huan‐Yuan
Published: May 2015

The stability constants of several divalent first row transition and trivalent lanthanide metal complexes were determined by capillary electrophoresis (CE) methods. Four different approaches, i.e. direct formation, ligand exchange, metal exchange and metal‐ligand double exchange were developed. To verify if these CE methods are indeed applicable, the stability constant of CuHEDTA was re‐determined to be 17.47 ± 0.20 (consistent with the published 17.50) using the CuEDTA and ZnHEDTA metal‐ligand double exchange approach. The stability constants of lanthanide (Ce3+ and Eu3+) and transition metal (Ni2+ and Zn2+) complexes of an aminopolycarboxylate ligand, DO2A (1,7‐dicarboxymethyl‐1,4,7,10‐tetraazacyclododecane) were measured under the direct complex formation condition. The stability constant of the NiDO2A complex was determined by the ligand exchange method using 1,4,8,11‐tetraazaundecane (2,3,2‐tet) as the competing ligand. The stability constant of CuDO2A complex was determined by the metal exchange method using Zn2+ ion as the competing metal ion, and complex formation competitions of Ni2+ and Cu2+ between DO2A and 2,3,2‐tet were studied by the metal‐ligand double exchange method. Effects of experimental conditions and the advantages and limitations of these CE methods are discussed.
Syntheses and Characterization of Molybdenum Complexes with the (1,3‐Dithioliumyl)diphenylphosphine Containing Ligands
Authors: Yih Kuang‐Hway
Published: May 2015

Treatment of [Et4N][Mo(CO)5(PPh2CS2)], 1 with unsaturated organic halides afforded the neutral complexes Mo(CO)5(PPh2CS2R) (R = CH2CN, 2; R = CH2C≡CH, 3). Alkylation reactions take place at the sulfur atom. Protonation of complex 2 and 3 with HBF4 produced the intramolecular cyclization products [Mo(CO)5(PPh2CS2C2H3N)][BF4], 4 and [Mo(CO)5(PPh2CS2C3H4)][BF4], 5, respectively. In complex 4 and 5, two five‐membered 1,3‐dithiolium rings formed. Protonation of 3 to 5 is not reversible, but deprotonation of 4 by n‐BuLi or PPh3 gave 2 quantitatively. Treatment of 4 with n‐Bu4NF yielded complex Mo(CO)5PPh2F, 6 and 2 with 1:1 ratio, but in the reaction of 5 and n‐Bu4NF only compound 6 was formed. All of these complexes are identified by spectroscopic methods.
Dimolybdenum Complexes Containing Pairs of Bridging Diphosphine and Carboxylate Ligands. Synthesis and Structures of trans‐Mo2(O2CCH3)2(μ‐dppa)2(BF4)2 and trans‐Mo2X2(O2C(CH2)nCH3)2(μ‐dppa)2 (n = 2, 10 or 12; X = Cl or Br; dppa = N,N‐Bis(diphenylphosphino)amine)
Authors: Tseng Gwo‐Wei , Suen Maw‐Cherng , Chen Jhy‐Der , Hwang Jiunn‐Jer , Chen‐Yang Yui Whei , Keng Tai‐Chiun , Wang Ju‐Chun
Published: May 2015

The red complex trans‐Mo2(O2CCH3)2(μ‐dppa)2(BF4)2, 1, was prepared by reaction of [Mo2(O2CCH3)2(CH3CN)6][BF4]2 with dppa (dppa = Ph2PN(H)PPh2) in THF. The reactions of Mo2(O2C(CH2)nCH3)4 with dppa and (CH3)3SiX (X = Cl or Br) afforded the complexes trans‐Mo2X2(O2C(CH2)nCH3)2(μ‐dppa)2 (X = Cl, n = 2, 2; X = Br, n = 2, 3; X = Cl, n = 10, 4; X = Cl, n = 12, 5). Their UV‐vis, IR and 31P{1H}‐NMR spectra have been recorded and the structures of 1, 2 and 3 have been determined. Crystal data for 1: space group P21/n, a = 12.243(1) Å, b = 17.222(1) Å, c = 13.266(1) Å, β = 95.529(1)°, V = 2784.1(6) Å3, Z = 2, with final residuals R = 0.0509 and Rw = 0.0582. Crystal data for 24CH3Cl2: space group P21/n, a = 13.438(1) Å, b = 19.276(1) Å, c = 14.182(1) Å, β = 111.464(1)°, V = 3418.9(6) Å3, Z = 2, with final residuals R = 0.0492 and Rw = 0.0695. Crystal data for 3·4CH2Cl2: space group P21/n, a= 13.579(1) Å, b = 19.425(1) Å, c = 14.199(1) Å, β = 111.881(2)°, V = 3475.6(7) Å3, Z = 2, with final residuals R = 0.0703 and Rw = 0.0851. Comparison of the structural data shows that the effect of the axial ligand on weakening the Mo‐Mo bond strength is X− > CH3CN > BF4−. The Tm values are 121.7 °C for 2, 111.1 °C for 3 and 91.5 °C for 5, respectively.
Synthesis and Pyrolytical Solid‐Phase Structural Transformations of New Oxorhenium(V) Complexes with 2‐Benzoxazolethione
Authors: Mashaly Mahmoud M. , El‐Behairy Mostafa , Khalil Saied M. E.
Published: May 2015

2‐Benzoxazolethione reacts with the parent oxorhenium(V) complex, H2[ReOCl5], to yield either mononuclear or dinuclear complexes depending on the metal: ligand molar ratio and the concentration of hydrochloric acid containing the parent rhenium complex. The mononuclear complexs [ReOLCl(OH2)3]Cl2, [ReOL2(OH2)3]Cl3 and [ReOLCl3(OH2)]; and dinuclear complexes [Re2O3(μ‐L)2Cl4]·2H2O and [Re2O2(μ‐L)L2Cl6]‐2H2O were obtained. Both types of complexes have octahedral configurations. The mononuclear complexes prepared in 6N HCl or in 9N HCl undergo irreversible one‐step solid‐phase thermochromism transformation, thus, the colour of complexes changed from green to brown, black or bluish‐green, upon heating. For the complexes obtained in 6N HCl, this step corresponds to structural changes due to the formation of other types of dinuclear complexes, while the mononuclear complex obtained in 9N HCl changes to another mononuclear complex with different coordination sites. On the other hand, the colour of the dinuclear complexes prepared in 2N HCl changed from brown to black, upon heating, in one step solid‐phase thermochromism transformation corresponding to a change in the mode of coordination sites of the organic ligand. All thermal products obtained have octahedral configurations. The ligand behaves in these complexes either as a neutral, mono‐, bidentate or monoanionic bidentate towards the oxorhenium ions. All complexes and the corresponding thermal products were isolated and their structures were elucidated by elemental analyses, conductance, IR and electronic absorption spectra, magnetic moments, 1H NMR and TG‐DTA measurements as well as by mass spectroscopy.
Assessing the Apparent Effective Thickness of the Supported Hybrid Bilayer Membranes Consisting of Octadecanethiol and Phospholipid by ac Impedance Spectroscopy
Authors: Cui Xiaoli , Jiang Dianlu , Diao Peng , Li Junxin , Jia Zhenbin , Tong Ruting , Wang Xinkui
Published: May 2015

The electrochemical behavior of the gold electrode modified by hybrid bilayer membranes in different concentrations of Fe(CN)63−/Fe(CN)64− was investigated by electrochemical impedance spectroscopy and cyclic voltammetry technology. The electron transfer between gold and the redox species separated by the hybrid bilayers assembly was completed by an electron tunneling process. A detailed equivalent circuit for electron transport across the HBMs is proposed. It was found that the apparent effective thickness of the hybrid bilayer membranes was lower than that of the sum of the chain length of octadecanethiol and phospholipid so some possible collapsed sites might exist at the hybrid bilayer membranes.
A Convenient Solid State Method for Preparing Aryl Azo Compounds
Authors: Wang Cai‐Lan , Wang Yu‐Lu , Wang Xiao‐Yang , Wang Xiao‐Xia , Li Jian‐Ping
Published: May 2015

A convenient solid state reaction using ferric nitrate to oxidize substituted semicarbazide for preparing azo ureas has been reported for the first time. Eight phenyldiazenecarboxylic acid anilide derivatives, have been synthesized in excellent yields with cheap reagents and simple instruments under room temperature.
The Constituents of Cananga odorata
Authors: Hsieh Tian‐Jye , Chang Fang‐Rong , Wu Yang‐Chang
Published: May 2015

Sixteen compounds, (+)‐ushinsunine‐β‐N‐oxide (1), cleistopholine (2), liriodenine (3), (‐)‐anonaine (4), (+)‐nornuciferine (5), (+)‐N‐acetylnornuciferine (6), (‐)‐ushinsunine (7), (‐)‐norushinsunine (8), (‐)‐asimilobine (9), (+)‐reticuline (10), N‐trans‐feruloyltyramine (11), β‐sitosterol (12) and stigmasterol (13), lyscamine (14), (‐)‐anaxagoreine (15) and trans‐cinnamic acid (16) were isolated from the methanolic extract of the Cananga odorata. Among them, 1 is a new stereoisomer of ushinsunine‐β‐N‐oxide. The structures of these compounds were established by means of spectral experiments.
Tannin and Related Compounds from Terminalia catappa and Terminalia parviflora
Authors: Lin Ta‐Chen , Hsu Feng‐Lin
Published: May 2015

Continuing chemical examination on tannins and related compounds of Combretaceous plants has led to the isolation of one novel complex type tannin, catappanin A, together with two phenolcarboxylic acids, two phenol glucoside gallates, seven ellagic tannins, one other hydrolyzable tannin, four flavan‐3‐ols and two complex type tannins from the bark of Terminalia catappa. In addition, from the bark of Terminalia parviflora one new methyl glucoside gallate, methyl 3,6‐di‐O‐galloyl‐β‐D‐glucoside, three phenolcarboxylic acids, three gallotannins, six ellagitannins and three other hydrolyzable tannins were isolated. Their structures were elucidated on the basis of chemical and spectroscopic evidence.
The Formation of Triple Stranded Helix of Oligodeoxyribonucleotides Containing 8‐Oxo‐2′‐deoxyadenosine
Authors: Lin Shwu‐Bin , Wu Chia‐Mau , Lin Wei‐Chen , Kan Lou‐Sing
Published: May 2015

Triple stranded DNA helix (triplex) formation is limited by pH and the sequence of oligodeoxyribonucleotide. In this study, the 8‐oxo‐2′‐deoxyadenosine (8‐oxoA) can replace 2′‐deoxycytidine for forming a base triad with a base pair guanine and cytosine. The target for the triplex formation is a motif of a promotor (5′‐d‐TTGGGGGGGAA, −3 – −12 of PKCα m‐RNA) of mouse protein kinase Cα. The probes contain 20 bases with a common sequence 5′‐d‐XXXXXXTTCCCCCCAA. The XXXXXX portion may contain either 5‐methyl‐2′‐deoxycytidines, six 8‐oxoA's or both. Only the probe with a motif of six 8‐oxoA's can for triplex with the target in the presence of magnesium ion and spermine at neutral pH. Therefore, 8‐oxoA is useful for triplex formation under physiological conditions.
Bacterially Expressed Raf‐1 Catalytic Domain is Highly Associated with GroEL
Authors: Ho Mengfei , Wilson Brenda A. , Peterson John W.
Published: May 2015

Raf‐1 is a key protein kinase in the mitogen‐activated protein kinase cascade. We have subcloned the catalytic domain of Raf‐1 into the bacterial expression vectors, pTrcHisB and pGEX‐6P‐1, denoted as His6‐ΔNRaf and GST‐RafBXB, respectively. Chromatography of the recombinant proteins using Ni‐NTA agarose, Sephacryl S‐300, and glutathione‐sepharose revealed association of Raf‐1 catalytic domain in a high molecular weight complex with a 57 kDa protein. Microsequencing of this 57 kDa protein identified it as GroEL, a heat shock protein in E. coli important for protein folding. GroEL association with the Raf‐1 catalytic domain is specific, as evidenced by its association with both Raf‐1 constructs. Native‐PAGE gels and Western analysis of gel filtration fractions revealed association of the catalytic domain with a large molecular weight complex consistent with the tetradecameric complex of GroEL. A peptide library of 384 do‐decapeptides corresponding to the entire catalytic domain of Raf‐1 was constructed by the spot synthesis method. Binding of GroEL and ELISA analysis revealed a preferential GroEL binding site in the β1 sheet region of the Raf‐1 kinase domain.
Beckmann Rearrangement of Cyclohexanone Oxime over Borate‐Pillared LDHs
Authors: Lin Jenn‐Tsuen , Tsai Shi‐Jane , Cheng Soofin
Published: May 2015

Borate‐pillared layered double hydroxides (LDHs) were studied as catalysts in vapor‐phase Beckmann rearrangement of cyclohexanone oxime to caprolactam under atmospheric pressure. The results were compared with those over the physical admixture of LDH and boria, the co‐precipitate of B‐Mg‐Al hydroxide, and the pristine LDH and boria compounds. Although oxime conversion and caprolactam selectivity declined with time‐on‐stream over all the catalysts, borate‐pillared LDH catalysts could retain activity longer than pure boria or those prepared by other methods. The decay rate however was affected by the Mg/Al ratio, the boron content and the form of LDH precursor used. The LDH itself functioning as a basic catalyst contributed to the formation of side products such as cyclohexanone and 2‐cyclohexen‐1‐one. The physical admixtures of LDH and boria had catalytic properties more close to that of pure boria, which gave high caprolactam selectivities but lost the activity in several hours on stream. The high resistance to decay of the pillared catalysts was attributed to that boria in the interlayer of LDH was stabilized and prevented from structural transformation to a glassy state of no activity.
Lignans, Flavonoids and Phenolic Derivatives from Taxus mairei
Authors: Yang Shung‐Jim , Fang Jim‐Min , Cheng Yu‐Shia
Published: May 2015

From the twigs of Taxus mairei, 35 lignans, 2 sesquilignans, 4 flavonoids, 3 bisflavonoids, 13 phenolic derivatives, 2 sesquiterpenes, 3 bisnorsesquiterpenes, 3 long‐chain carboxylic acids and 4 steroids were isolated. The new lignans and phenolic glucosides include 7′‐hydroxynortrachelogenin, 7‐hydroxymatairesinol, 3′‐O‐demethylepipinoresinol, taxiresinol 9‐acetate, 3′‐O‐demethyltanegool, 8′‐epitanegool, 3,3′‐dimethoxy‐4,4′,9‐trihydroxy‐7,9′‐epoxylignan‐7′‐one, 3‐O‐demethyldihydrodehydrodiconiferyl alcohol, taxumaiglucoside A heptaacetate, taxumaiglucoside B heptaacetate, and taxumaiglucoside C heptaacetate. Their structures were determined by spectral methods.
Pregnane Glycosides from Gymnema alternifolium
Authors: Lin Yun‐Lian , Wu Yan‐Ming , Kuo Yueh‐Hsiung , Chen Chieh‐Fu
Published: May 2015

Three new polyoxypregnane glycosides, gymnepregosides G, H, and I, together with four known compounds were isolated from the stems of Gymnema alternifolium. The structural elucidation were determined principally by spectral data, and assigned to be 12‐O‐cinnamoyl‐3β,5α,8β,12β,14β,17β,20‐heptahydroxy‐(20S)‐pregn‐6‐enyl‐3‐O‐β‐D‐cymaropyranoside (1), 20‐O‐benzoyl‐12‐O‐cinnamoyl‐3β,5α,8β,12β,14β,17β,20‐heptahydroxy‐(20S)‐pregn‐6‐enyl‐3‐O‐β‐D‐cymaropyranoside (2), and penupogenin 3‐O‐β‐D‐cymaropyranoside (3), respectively.
Determination of Mercury in Urine and Seawater by Flow Injection Vapor Generation Isotope Dilution Inductively Coupled Plasma Mass Spectrometry
Authors: Wei Ming‐Tsai , Jiang Shiuh‐Jen
Published: May 2015

A simple and inexpensive laboratory‐built vapor generator was used with inductively coupled plasma mass spectrometry (ICP‐MS) for the determination of mercury in urine and seawater samples. The applications of vapor generation ICP‐MS alleviated the non‐spectroscopic interferences and the sensitivity problem of mercury determination encountered when the conventional pneumatic nebulizer was used for sample introduction. The concentration of mercury was determined by isotope dilution method. The isotope ratio of mercury was calculated from the peak areas of each injection peak. The repeatability of the peak areas and isotope ratio determinations of seven consecutive injections of 1 ng mL−1 Hg solution were 2.3% and 2.2%, respectively. This method has a detection limit of 0.07 ng mL−1 for mercury. This method was applied to determine mercury in a CASS‐3 nearshore seawater reference sample, NASS‐4 open ocean seawater reference sample, NIST SRM 2670 freeze‐dried urine reference sample and several urine and seawater samples collected from National Sun Yat‐Sen University. The results for the reference samples agreed satisfactorily with the reference values. Results for other samples analyzed by the isotope dilution method and the method of standard additions agreed satisfactorily. Precision was better than 10% for most of the determinations.
Kinetic Study of the Ru(II) Catalyzed Oxidation of Pentacyanoferrate(ll) Complexes by Peroxydisulfate
Authors: Wei Shi‐Kai , Yeh Andrew
Published: May 2015

The oxidation reactions of Fe(CN)5L3− (L = 4‐ampy, py, dpa) complexes by S2O82− were catalyzed upon the addition of a trace amount of Ru(NH3)5L′2+ (L′ = pz, py or dcb) complex, and the reaction becomes zero‐order in Fe(II). The reaction time is ∼102 fold faster than the simple Fe(CN)5L3−‐S2O82− system. The mechanism of this Ru(II) catalyzed redox reaction is proposed as

Ru(NH3)5L′2+ + 1/2 S2O82− → Ru(NH3)5L′3+ + SO42−

Ru(NH3)5L′3+ + Fe(CN)5L3− ⇌ Ru(NH3)5L′2+ + Fe(CN)5L2−
Structure, Magnetic Properties and Catalase‐like Activity of Asymmetric Dimanganese(III, III) Carboxylate Complexes with Salicylaldimine Ligands
Authors: Chang Kuo‐Hui , Wei Ho‐Hsiang , Hong Dang‐Ming
Published: May 2015

The crystal structures, magnetic properties, and catalase‐like activities of assymmetric dinuclear manganese(III, III) complexes, [Mn2III, III(spa)2(μ‐Me3CCO2)(Me3CCO2)(CH3OH)] (1) and [Mn2III, III(vpa)2(μ‐Me3CCO2)(Me3CCO2)(CH3OH)] (2), (H2spa = 3‐salicyclideneamino‐1‐propanol, H2vpa = O‐vanillin), were reported. The crystal structures of complexes 1 and 2 consist of the same discrete asymmetric coordination environment of dinuclear clusters, where the two manganese atoms are bridged by two alkoxo oxygens of the spa or vpa ligands and one bidentate carboxylate ion, whereas an additional oxygen atom of monodentate carboxylate coordinated to the first metal ion, and the second metal ion was coordinated by one oxygen atom of the solvent CH3OH. Magnetic investigations (2–300 K) reveal an intramolecular antiferromagnetic spin exchange interaction with axial‐field splittings: J = −12.3 cm−1 (D = −0.10 cm−1) and J = −13.3 cm−1 (D = −0.15 cm−1) for complexes 1 and 2, respectively. The complexes should show catalase‐like activity for H2O2 disproportionation in CH3OH solvent at 25° with rate constants of k = 6.35 dm3moI−1s−1 and 6.20 dm3mol−1s−1 for complexes 1 and 2, respectively.
Thermodynamics of Binding 2,2′‐Bipyridineglycinato Palladium (II) Chloride on Human Serum Albumin
Authors: Saboury A. A. , Shamsaei A. A. , Moosavi‐Movahedi A. A. , Mansuri‐Torshizi H.
Published: May 2015

The interaction of human serum albumin (HSA) with 2,2′‐bipyridineglycinato palladium (II) chloride was studied by isothermal titration microcalorimetry at 27°C and equilibrium dialysis and UV‐Vis. spectrophotometry techniques at temperatures of 27 & 37°C in 2.5 mM phosphate buffer solution at pH = 7.0. The enthalpy of binding was calculated from binding data, which were obtained from equilibrium dialysis in terms of the Wyman binding potential theory related to the van't Hoff relation. The enthalpy of HSA unfolding was determined by subtraction of the microcalorimetric enthalpy (binding and unfolding enthalpies) and the enthalpy of binding. The enthalpy of HSA unfolding, due to the binding of that ligand, was 491.43 kJ mol−1.
Total Synthesis of (±)‐Iridolactone
Authors: Lee An‐Yang , Chang Meng‐Yang , Tai Huo‐Mu , Chang Nein‐Chen
Published: May 2015

A total synthesis of (±)‐iridolactone (1) from bicyclo[2.2.1]ketone 6 is described. Trisubstituted cyclopentenoid aldehyde 7 is a key intermediate.
Ene Reaction with Pummerer‐Type Reaction Intermediate of α‐(Methylthio)isobutyl Acetamide: A New Synthesis of Pellitorine
Authors: Chen Ling‐Ching , Kang Iou‐Jiun , Wang Huey‐Min
Published: May 2015

Pummerer‐type reaction intermediate 2 of α‐(methylthio)isobutyl acetamide (1) has been found to react with 1‐alkenes to afford ene adducts 3. Pellitorine 4 was synthesized from the adduct 3d.
Investigation of the Reaction of Roasted Serpentine Ore with Some Ammonium Salts
Authors: Abd‐Elzaher Mokhles M.
Published: May 2015

The reaction between roasted serpentine ore and ammonium sulfate was studied at the range of temperature 250–1000°C using different molar ratios to determine the maximum extraction of magnesia and also to characterize the different reaction products. The maximum extraction of MgO from the roasted ore reached 92.4% at 400°C. It was found from XRD that ammonium magnesium sulfate [(NH4)2Mg2(SO4)3] was produced as the main product at 400°C, which decomposes to magnesium sulfate at 500–600°C. The last compound decomposes to magnesium oxide at 900–1000°C. Thermal analysis of the reaction mixture confirmed the results obtained by XRD. Extraction of magnesia by ammonium chloride at 300–400°C showed low percentage of extraction (7.8%). Comparison was made between using ammonium chloride instead of sulfate taking into consideration the thermal decomposition products of both ammonium salts. Extraction of magnesia from the roasted ore by aqueous ammonium sulfate or ammonium chloride showed good results.
Influence of Short‐Chain Alcohols on the Micellization Parameters of Sodium Dodecyl Sulfate (SDS)
Authors: Safarpour M. A. , Rafati A. A. , Gharibi H. , Sameti M, Rezaie
Published: May 2015

The influence of short‐chain alcohol on the aggregation behavior of Sodium Dodecyl Sulfate (SDS) is investigated within a wide range of alcohol concentration by potentiometric technique. It is observed that aggregation behavior of SDS is a function of alcohol concentration. Variation of micellization parameters are studied in a wide range of alcohol concentration and the trend of changing of micellization parameters have been investigated. The variations of micellization parameters show several regularities. Finally, the relationships between these regularities and alcohol‐surfactant interactions have been explained.
Synthetic Applications of 3‐(Phenylsulfinyl)‐3‐sulfolene
Authors: Chou Shang‐Shing P. , Liang Pi‐Wei
Published: May 2015

The title compound 2 was readily prepared by MCPBA oxidation of the sulfide 1. Thermal desulfonylation of 2 gave the sulfoxide‐substituted diene 3. The Diels‐Alder reactions of 3 with various dienophiles gave the cyclized products 4‐9 in good yields. The regiochemistry was found to be dominated by the phenylsulfinyl group, but could be reversed by the presence of a Lewis acid. Deprotonation of 2 by BuLi, followed by the reaction with alkyl halides, gave the substituted 2‐sulfolenes 10. A synthetic application of 10 was demonstrated by converting 10e to the bicyclic product 11.
Syntheses of L‐Glutamic Acid Analogues for Neuroexcitatory Activity Studies
Authors: Hon Yung‐Son , Chang Yen‐Chung , Chu Kuan‐Po
Published: May 2015

Starting from D–serine, (2S,3S)‐, (2S,3R)‐substituted‐L‐glutamic acids were prepared via Claisen rearrangement methodology. A variety of the substituents can be introduced at the C‐3 of the L‐glutamic acid backbone.
Ultrafast Dynamics Probed by the Time‐Resolved Anisotropy Measurements
Authors: Hayashi M. , Yang T. S. , Liang K.‐K. , Chang C.‐H. , Chang R.‐L. , Lin S. H.
Published: May 2015

In this paper, we shall show that in order to effectively observe the quantum beat due to vibrational coherence by the anisotropy measurement, it is necessary to perform the frequency‐resolved measurement in the transient absorption. It is found that the quantum beat due to vibrational coherence cannot be observed if the ultrafast processes under observation do not involve an electronic transition.

In order to effectively observe the quantum beat due to vibronic coherence, it is necessary to perform the frequency‐integrated time‐resolved anisotropy measurement. We also show that it is usually difficult to obtain accurate dynamics information from the time‐resolved anisotropy measurement.
Theoretical Study of the Germylene Insertion Reaction into the A‐H Bond of First‐Row and Second‐Row AHn Hydrides
Authors: Su Ming‐Der , Chu San‐Yan
Published: May 2015

The insertion of dimethylgermylene into the A–H bond of AHn hydrides is calculated using the CCSD(T) method in comparsion with the density functional theory (B3LYP) with the 6‐311G* basis set. The B3LYP values reproduce the CCSD(T) results very well. The present theoretical calculations suggest that (a) for germylene insertions there is a very clear trend toward lower activation barriers and more exothermic interactions on going from left to right along a given row, and (b) for the second‐row hydrides, the insertion reactions are more exothermic than for the first‐row hydrides, and the reaction barriers are lower.
The Bonding Structure of Quadricyclanylidene Derivatives
Authors: Chow Tahsin J. , Lee Chia‐Fu , Lin Kuan‐Jiuh
Published: May 2015

The crystal structures of bisquadricyclanylidene 1, 7‐quadricyclanylidenenorbornadienes 2 and 3 are solved by X‐ray diffraction analyses. The bond lengths of the cyclopropyl moieties of 1, 2 and 3 are compared with several other quadricyclanylidene derivatives, and the differences are analyzed by computational models. The results showed that the variation of bond lengths in this series of compounds is related to the electronic nature of substituents.
Aluminium Chloride‐Catalyzed Intermolecular vs Intramolecular Friedel‐Crafts Reaction of Acrylanilides and 3‐Chloropropanamides
Authors: Chen I‐Li , Wang Tai‐Chi , Chen Yeh‐Long , Tzeng Cherng‐Chyi
Published: May 2015

3‐Phenylpropionanilide (4a) is obtained in a yield of 89% from acrylanilide by the treatment with AlCl3/benzene, compared with a yield of 39% by the 1,4‐conjugate addition of phenyllithium. The formation of 4a indicated that an intermolecular Friedel‐Crafts reaction occurred, rather than the relatively more facile intramolecular ring cyclization, and provided a more efficient route than a conjugate addition of phenyllithium for the preparation of 3‐phenylpropionanilide and its derivatives. Although the methoxy group is an activator of the nucleophilic substitution, introduction of a methoxy substituent at N‐phenyl did not increase the competitive capability of the intramolecular cyclization because of AlCl3‐catalyzed demethylation to form the ArOAlCl2 complex which decreased the availability of the π‐electron in the N‐phenyl aromatic system.
Chromatographic Chiral Recognition and Computer Aided Deconvolution of the Enantiomeric Secondary Alcohol with a Self‐Packed Chiral Stationary Phase HPLC Column
Authors: Cheng Cheanyeh , Wu Shouh‐Chwan
Published: May 2015

The γ‐aminopropyl‐derivatized silica was treated with the (R)‐(‐)‐N‐(3,5‐dinitrobenzoyl)‐α‐phenylglycine and was packed into a standard 250 mm × 4.5 mm HPLC column to perform the chiral separation of secondary alcohol. Enantiomers of four homologous series of aryl alkyl substituted alcohol were resolved in different degrees. The chiral recognition mechanism was proposed that could be used to rationalize well the elution order and the resolution between the R‐ and S‐configuration of a secondary alcohol. The unresolved peak of the enantiomers of 1‐phenylethanol and the partially resolved peak of the enantiomers of 1‐(1‐naphthyl)ethanol were deconvoluted by the assistance of computer and a program written in BASIC computer language. Two mathematical models were used for the deconvolution and were based on modified Gaussian functions with a fixed baseline that can take into account the skew of a chromatographic peak. Parameters in the mathematical model were estimated by using a nonlinear regression algorithm. The selected mathematical models were suitable for deconvolving the less skewed overlapping peaks of 1‐phenylethanol.
Syntheses of 4‐(5‐oxo‐1,2,4‐triazol‐3‐yl)‐sydnones and 4‐(4‐arylamino‐5‐oxo‐1,2,4‐triazol‐3‐yl)‐sydnones from Sydnone Derivatives and Their Fragments
Authors: Kuo W. F. , Lee C. Y. , Yeh M. Y.
Published: May 2015

4‐(5‐oxo‐1,2,4‐triazol‐3‐yl)‐sydnones 11 and 4‐(4‐arylamino‐5‐oxo‐1,2,4‐triazol‐3‐yl)‐sydnones 13 have been obtained from a‐chloroformylarylhydrazine hydrochloride 2. Moreover, the intermediates, including 3, 4, 9 and 10, in this study are synthetically informative and valuable. It is also noteworthy that three reactants, 1, 2 and sydnonecarbaldehydes, were prepared from sydnone derivatives and their fragments. The oxidative cyclizations of sydnonecarbaldehyde semicarbazones 9 and carbazones 10 with two different oxidizing agents (Cu(ClO4)2 and Fe(ClO4)3) have been extensively examined. The reaction time and the yields of cyclizations were affected by the substituents of semicarbazones 9 and carbazones 10.
Constituents of the Whole Herb of Clinoponium laxiflorum
Authors: Kuo Yueh‐Hsiung , Lee Shu‐Mei , Lai Jeng‐Shiow
Published: May 2015

The isolation and identification of twenty‐two components (including one new compound) from the whole herb of Clinoponium laxiflorum (Hay) Matsum (Labiatae) are described. Their structures were determined on the basis of spectral and chemical transformation. One new compound is methyl rosmarinate. The other twenty‐one compounds include three steroids (α‐spinasterol, α‐spinasteryl‐3‐O‐β‐D‐glucopyranoside, and β‐sitosteryl‐3‐O‐β‐glucopyranoside), three triterpenes (oleanolic acid, ursolic acid, and betulinic acid), nine flavonoids (didymin, apigenin‐7‐O‐β‐glucopyranoside, luteolin‐7‐O‐β‐glucopyranoside, isosakuranetin, narigenin, apigenin, luteolin, narirutin, and hesperidin), three lignolic acids (rosmarinic acid, 3‐(3,4‐dihydroxyphenyl)lactic acid, and caffeic acid), and three phenols (4‐hydroxybenzaldehyde, 3,4‐dihydroxybenzaldehyde, and 3,4‐dihydroxybenzoic acid).
Synthesis of Optically Active Tetraoxa‐Cage Compounds by Chemical Resolution
Authors: Chen I‐Chia , Wu Hsien‐Jen
Published: May 2015

The first synthesis of optically active tetraoxa‐cage compounds has been accomplished by using (‐)‐camphanic chloride as a resolving reagent in a short sequence. The synthesis of the tetraoxa‐cages with different functional groups on the side chain was also demonstrated.
Carbon‐13 Nuclear Magnetic Resonance Spectroscopic Analyses of 3‐Aryl‐3‐hydroxyl‐2,2,4,4‐tetramethylcyclobutanones and Related Compounds
Authors: Lin Shaw‐Tao , Lin Wen‐Chung , Yeh Yuen‐Han
Published: May 2015

A series of 2‐aryl‐2‐hydroxy‐1,1,3,3‐tetramethyl‐5,8‐dioxaspiro[3.4]octanes (1), 3‐aryl‐3‐hydyoxyl‐2,2,4,4‐tetyramethylcyclobutanones (2), and l‐aryl‐2,2,4‐trimethyl‐1,3‐pentadiones (3) were studied using 13C NMR analyses. The chemical shifts of C‐c are dependent on the substituent groups on the phenyl ring for compounds 1 (ρ =‐0.966, R2 = 0.987) and 2 (ρ = −1.378, R2 = 0.998). The chemical shifts of C‐a follow a similar trend (ρ =−0.926, R2 = 0.989). In the case of compounds 3, C‐c yielded the opposite trend with very poor correlation coefficiency (ρ = 1.22, R2 = 0.179). This result reveals the field effect of a polar bond and resonance‐induced changes in pi electron‐density at C‐1 on the cyclobutanering series.
Dimerization and Oligomerization of Ethylene Catalyzed by a Palladium(II) Complex with Imine‐phosphine Ligand
Authors: Chen Jwu‐Ting , Liu Shiuh‐Tzung , Zhao Ke‐Qing
Published: May 2015

The palladium‐iminophosphine complex [Pd(P‐N)(CH3)Cl] (P‐N = o‐diphenyl‐phosphino‐N‐benzaldimine) has been found to be a catalyst for dimerization and trimerization of ethylene. Some mechanistic insight concerning this oligomerization is discussed.
A Convergent Formal Synthesis of (±)‐Pumiliotoxin C
Authors: Shieh Ya‐Sheng , Yeh Ming‐Chang P. , Rao U. Narasimha
Published: May 2015

A short approach to a key precursor in the synthesis of (±)‐pumiliotoxin C was achieved from [(6–9‐ẽ)‐ethyl cis‐6,8‐nonadienoate]tricarbonyliron complex in five steps.
Determination of Vitamin D3 Metabolites Using High‐Performance Liquid Chromatography or Immunoaffinity Chromatography
Authors: Shimada Kazutake , Mitamura Kuniko , Higashi Tatsuya
Published: May 2015

Our investigation of the analysis of vitamin D3 metabolites has been reviewed. The development of high‐performance liquid chromatographic methods for the quantitative determination of 25‐hydroxyvitamin D3 3‐sulfate and 25‐hydroxyvitamin D3, which are the major circulating metabolites of vitamin D3 in human serum/plasma, has been described. The developed methods were applied to the determination of the correlation between the concentration of the sulfate and its genin in healthy subjects and patients with chronic renal failure. The development of immunoaffinity chromatography immobilizing the highly specific anti‐1,25‐dihydroxyvitamin D3 antibody for the pretreatment of radioreceptor assay of 1,25‐dihydroxyvitamin D3, which is the active metabolite of vitamin D3, is also described.
Photodissociation Spectroscopy and Dynamics of Weakly Bonded Metal Ion—Ethylene Complexes
Authors: Chen J. , Wong T.H. , Kleiber P.D.
Published: May 2015

The photodissociation spectroscopy of weakly bonded bimolecular complexes can give important insight into fundamental molecular interactions and dynamics. We have applied these techniques to a study of metal ion‐ethylene interactions in the Mg+(3s)‐C2H4 and Al+(3s2)‐C2H4 π‐bonded complexes. Experimental work is supported by ab‐initio electronic structure calculations. These experiments allow us to explore and compare the chemical binding, electronic structure, and nonadiabatic dissociation dynamics of these complexes.
Conformational Analysis of 1,2‐Di‐O‐Octanoyl‐Ethylene‐Glycerol During Aggregation
Authors: Lin Gialih , Lu Chun‐Ping
Published: May 2015

Conformational analysis of 1,2‐di‐O‐octanoyl‐ethylene‐glycerol during aggregation by 600 MHz 1H NMR is described. In monomeric states, 1,2‐di‐O‐octanoyl‐ethylene‐glycerol exists in 75% anti‐conformer and 25% gauche‐conformer. The first critical micelle concentration of 1,2‐di‐O‐octanoyl‐ethylene‐glycerol is calculated to be 4.5 mM. In micellar states, 1,2‐di‐O‐octanoyl‐ethylene‐glycerol exists in 25% anti‐conformer and 75%) gauche‐conformer. When the concentration is greater than 10 mM, 1,2‐di‐O‐octanoyl‐ethylene‐glycerol probably aggregates to become the larger micelle, micelle II. In the second micellar state, 1,2‐di‐O‐octanoylethylene‐glycerol only exists in gauche‐conformer.
Ironcarbonyl‐Mediated Alkene Hydroamidation of 7‐Oxabenzonorbornadiene
Authors: Sun Chia‐Hsing , Ho Tzay‐Shiou , Wang Ju‐Chun
Published: May 2015

Iron carbonyl‐mediated alkene hydroamidation of 7‐oxabenzonorbornadiene was accomplished under very mild conditions as the result of nucleophilic attack of amines on iron‐coordinating CO to produce exo‐5‐(alkylaminocarbonyl)‐7‐oxabenzobicyclo[2.2.1]hept‐2‐ene derivatives.
Diterpenoids from Isodon Eriocalyx
Authors: Chen Neng‐Yu , Tian Min‐Qing , Wu Rui , Sun Han‐Dong , Li Chao‐Ming , Lin Zhong‐Wen
Published: May 2015

Two new diterpenoids, Maoecrystal U and epi‐maoecrystal P, together with nine known diterpenoids and eight other known compounds were isolated from Isodon eriocalyx ( ). The structures of two new diterpenoids were elucidated as 6β‐acetoxy‐15β‐hydroxy‐3α,20‐epoxy‐ent‐kaur‐16‐ene‐1,7‐dione and 16(S)‐methoxymethy‐6β,7β‐dihydroxy‐7α,20‐epoxy‐ent‐kaur‐2,3‐ethenylene‐1,15‐dione on the basis of spectroscopic evidence, especially by 2D NMR techniques.
Phytochemical and Pharmacological Studies on Chinese Paeonia Species
Authors: Ding Hsiou‐Yu , Lin Hang‐Ching , Teng Che‐Ming , Wu Yang‐Chang
Published: May 2015

A new monoterpene glycoside, mudanpioside J (3), was isolated from the root cortex of Paeonia suffruticosa. Its structure has been established on the basis of spectral evidence. In addition, six known compounds, campesterol (4), 4‐hydroxyacetopenone (5), kaempferol (6), 3‐hydroxy‐4‐methoxybenzoic acid (7), hederagenin (8) and galloylpaeoniflorin (9) were also isolated. A screening test of monoterpene glycosides and aromatic acids derived from P. suffruticosa and P. lactiflora on arachidonic acid, thrombin, collagen and PAF induced rabbit platelet aggregation suggests aromatic acids may play an important role in inhibition of platelet aggregation, inflammation and hemorrhage due to bacterial infection.