bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Consumer Subsidy on Green Technology Innovations for Vehicles and Environmental Impact
Authors: Zhang Juan , Wang Ziyue , Zhao Huiju
Published: October 2020

In the pressure of excessive resource consumption and serious environmental pollution, governments provide various consumer subsidies to promote sales of energy-saving vehicles, including the energy-saving fuel vehicle (FV) and the pure electric vehicle (EV) in the automobile industry. Utilizing a Hotelling model, this paper explores two competing firms’ decisions on the selection of green technology innovations for vehicles, namely producing either the energy-saving FV or the pure EV, while the two vehicles are different from each other on not only the energy-saving level but also the consumer’s acceptance. We further explore the impact of the government’s consumer subsidy on the profits, environment, and consumer surplus. We find that the two competing firms’ equilibrium selections of green technology innovations for vehicles change as the variable manufacturing cost of the pure EV varies. In particular, when the variable manufacturing cost of the pure EV is moderate, the firm with a lower technology capacity for improving the energy-saving level of the FV (i.e., firm 2) will produce the pure EV while the other firm (i.e., firm 1) produces the energy-saving FV, and the converse is not true. In this case, the decreasing variable manufacturing cost of the pure EV will benefit firm 2 and make firm 1 lose in a competing context. In particular, both firms would charge lower retail prices as the variable manufacturing cost of the EV decreases. In addition, we find that although the consumer subsidy could reduce the purchasing cost for the consumer and promote both firms to produce higher energy-saving level vehicles, a firm can still reduce its retail price under certain conditions because of the competition between the two firms. Finally, we prove that the consumer subsidy can be always beneficial to the environment, while it may hurt the consumer surplus and the firms’ profits under certain conditions. The results provide suggestions for governments to adopt an appropriate consumer subsidy program from perspectives of the consumer, environment, and economy.
Qualitative Analysis by Experts of the Essential Elements of the Nursing Practice Environments Proposed by the TOP10 Questionnaire of Assessment of Environments in Primary Health Care
Authors: Martínez-Riera José Ramón , Juárez-Vela Raúl , Díaz-Herrera Miguel Ángel , Montejano-Lozoya Raimunda , Doménech-Briz Vicente , Benavent-Cervera José Vicente , Cabellos-García Ana Cristina , Melo Pedro , Nguyen Tam H. , Gea-Caballero Vicente
Published: October 2020

Background: A short TOP10 scale based on the Practice Environment Scale-Nursing Work Index questionnaire measures the characteristics of nursing work environments. Positive environments result in better quality care and health outcomes. Objective: To identify a small number of core elements that would facilitate more effective interventions by nurse managers, and compare them with the essential elements proposed by the TOP10. Method: Qualitative research by a nominal group of eight experts. The content analysis was combined with descriptive data. Results: Ten most important items were selected and analyzed by the expert group. A high level of consensus in four items (2, 15, 20, 31) and an acceptable consensus in five items was reached (6, 11, 14, 18, 26). The tenth item in the top ten was selected from content analysis (19). The expert group agreed 90% with the elements selected as essential to the TOP10. Conclusion: The expert group achieved a high level of consensus that supports 90% of the essential elements of primary care settings proposed by the TOP10 questionnaire. Organizational changes implemented by managers to improve working environments must be prioritized following our results, so care delivery and health outcomes can be further improved.
Erratum: Hosokawa, R., et al. Associations between Healthcare Resources and Healthy Life Expectancy: A Descriptive Study across Secondary Medical Areas in Japan. Int. J. Environ. Res. Public Health 2020, 17, 6301
Authors: Hosokawa Rikuya , Ojima Toshiyuki , Myojin Tomoya , Aida Jun , Kondo Katsunori , Kondo Naoki
Published: October 2020

Due to an error during production, the legend of Figure 2 in the published paper [...]
Improving Consumption and Purchases of Healthier Foods in Retail Environments: A Systematic Review
Authors: Karpyn Allison , McCallops Kathleen , Wolgast Henry , Glanz Karen
Published: October 2020

This review examines current research on manipulations of U.S. food retail environments to promote healthier food purchasing and consumption. Studies reviewed use marketing strategies defined as the 4Ps (product, price, placement, promotion) to examine results based on single- and multi-component interventions by study design, outcome, and which of the “Ps” was targeted. Nine electronic databases were searched for publications from 2010 to 2019, followed by forward and backward searches. Studies were included if the intervention was initiated by a researcher or retailer, conducted in-store, and manipulated the retail environment. Of the unique 596 studies initially identified, 64 studies met inclusion criteria. Findings show that 56 studies had at least one positive effect related to healthier food consumption or purchasing. Thirty studies used single-component interventions, while 34 were multi-component. Promotion was the most commonly utilized marketing strategy, while manipulating promotion, placement, and product was the most common for multi-component interventions. Only 14 of the 64 studies were experimental and included objective outcome data. Future research should emphasize rigorous designs and objective outcomes. Research is also needed to understand individual and additive effects of multi-component interventions on sales outcomes, substitution effects of healthy food purchases, and sustainability of impacts.
Elder Mistreatment and Psychological Well-Being among Older Americans
Authors: Berkowsky Ronald W.
Published: October 2020

Elder mistreatment is a major public health issue both in the US and around the globe. While extensive research has elucidated the association between elder mistreatment and health in older adults, little is known about the relationship between elder mistreatment and more eudaimonic measures of psychological well-being. Using data from the 2011 wave of the Wisconsin Longitudinal Study, this project examined the association between older adults’ experience with varied forms of elder mistreatment and eudaimonic dimensions of psychological well-being including autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance. Ordinary least squares regression analyses found significant associations between experiences of elder mistreatment and psychological well-being. In particular, older adults who reported feeling that someone was too controlling over their daily lives and older adults who reported making donations to organizations they later worried were not legitimate reported significantly lower scores on all six psychological well-being dimensions. The results of this study suggest the negative effects of elder mistreatment can extend to more eudaimonic feelings of well-being, and programs designed to treat victims of elder mistreatment should incorporate strategies that help strengthen psychological well-being.
Liver Cancer Incidence and Area-Level Geographic Disparities in Pennsylvania—A Geo-Additive Approach
Authors: Ortiz Angel G. , Wiese Daniel , Sorice Kristen A. , Nguyen Minhhuyen , González Evelyn T. , Henry Kevin A. , Lynch Shannon M.
Published: October 2020

Many neighborhood socioeconomic index measures (nSES) that capture neighborhood deprivation exist but the impact of measure selection on liver cancer (LC) geographic disparities remains unclear. We introduce a Bayesian geoadditive modeling approach to identify clusters in Pennsylvania (PA) with higher than expected LC incidence rates, adjusted for individual-level factors (age, sex, race, diagnosis year) and compared them to models with 7 different nSES index measures to elucidate the impact of nSES and measure selection on LC geospatial variation. LC cases diagnosed from 2007–2014 were obtained from the PA Cancer Registry and linked to nSES measures from U.S. census at the Census Tract (CT) level. Relative Risks (RR) were estimated for each CT, adjusted for individual-level factors (baseline model). Each nSES measure was added to the baseline model and changes in model fit, geographic disparity and state-wide RR ranges were compared. All 7 nSES measures were strongly associated with high risk clusters. Tract-level RR ranges and geographic disparity from the baseline model were attenuated after adjustment for nSES measures. Depending on the nSES measure selected, up to 60% of the LC burden could be explained, suggesting methodologic evaluations of multiple nSES measures may be warranted in future studies to inform LC prevention efforts.
Associations of Dietary Bioactive Compounds with Maternal Adiposity and Inflammation in Gestational Diabetes: An Update on Observational and Clinical Studies
Authors: Davis Dustin W. , Crew Jeannette , Planinic Petar , Alexander James M. , Basu Arpita
Published: October 2020

Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. Maternal obesity, oxidative stress, and inflammation have been implicated in GDM. In non-pregnant adults, intakes of dietary bioactive compounds inversely associate with insulin resistance and inflammation. However, associations of dietary bioactive compounds with biomarkers of adiposity, antioxidant vitamin and mineral status, oxidative stress, and inflammation in GDM have not been fully elucidated. We addressed this gap by conducting a semi-quantitative review of observational studies and randomized controlled trials published between 2010 and 2020 and retrieved from Google Scholar, Medline, and PubMed. Our analysis revealed that women with GDM are more likely to consume a pro-inflammatory diet before pregnancy and tend to consume fewer antioxidant vitamins and minerals during pregnancy than healthy pregnant women. Women with GDM also have lower blood levels of vitamins A, C, and D and certain adipokines. Several dietary bioactive compounds were noted to improve antioxidant status and biomarkers of inflammation. The Dietary Approaches to Stop Hypertension (DASH) diet and soybean oligosaccharides increased antioxidant enzyme levels. Supplementing n-3 fatty acids, probiotics, synbiotics, and trace elements increased antioxidant enzymes and reduced hs-CRP and MDA. Improvements in inflammation by vitamin D may be contingent upon co-supplementation with other dietary bioactive compounds.
Are There Heterogeneous Impacts of National Income on Mental Health?
Authors: Huang Zimei , Li Tinghui , Xu Mark
Published: October 2020

Understanding heterogeneous impact and mechanisms between national income and mental health are crucial to develop prevention and intervention strategies. Based on panel data from 2007 to 2017, this study explores the heterogeneous impact of national income on different types of mental health. Then, it analyzes the heterogeneous impact among countries with different income levels. Furthermore, the heterogeneous moderating effects of national income on mental health mechanisms are elaborated and the findings reveal several key conclusions: firstly, national income exerts a heterogeneous impact on different types of mental health. Rising national income is conducive to increase people’s happiness and reduce their prevalence of anxiety disorders, but it increases the prevalence of depression disorders. Secondly, national income has a heterogeneous impact on different types of mental health among countries with different income levels. Furthermore, the heterogeneous influence mechanism of national income on mental health is mainly reflected in different types of mental health. Unemployment, social support and freedom can moderate the relationship between national income and depression, while social support, positive affect and negative affect can moderate the relationship between national income and anxiety. Finally, based on the conclusions of quantitative analysis, some important policy recommendations are proposed for policy makers.
Klebsiella and Enterobacter Isolated from Mangrove Wetland Soils in Thailand and Their Application in Biological Decolorization of Textile Reactive Dyes
Authors: Chantarasiri Aiya
Published: October 2020

Wastewater released from textile and dye-based industries is one of the major concerns for human and aquatic beings. Biological decolorization using ligninolytic bacteria has been considered as an effective and alternative approach for the treatment of dyeing wastewater. This study aimed to assess the isolation, characterization and application of soil bacteria isolated from mangrove wetlands in Thailand. Four active bacteria were genetically identified and designated as Klebsiella pneumoniae strain RY10302, Enterobacter sp. strain RY10402, Enterobacter sp. strain RY11902 and Enterobacter sp. strain RY11903. They were observed for ligninolytic activity and decolorization of nine reactive dyes under experimental conditions. All bacteria exhibited strong decolorization efficiency within 72 h of incubation at 0.01% (w/v) of reactive dyes. The decolorization percentage varied from 20% (C.I. Reactive Red 195 decolorized by K. pneumoniae strain RY10302) to 92% (C.I. Reactive Blue 194 decolorized by Enterobacter sp. strain RY11902) in the case of bacterial monoculture, whereas the decolorization percentage for a mixed culture of four bacteria varied from 58% (C.I. Reactive Blue 19) to 94% (C.I. Reactive Black 1). These findings confer the possibility of using these bacteria for the biological decolorization of dyeing wastewater.
Mediating and Moderating Factors of Adherence to Nutrition and Physical Activity Guidelines, Breastfeeding Experience, and Spousal Support on the Relationship between Stress and Quality of Life in Breast Cancer Survivors
Authors: Kang Nam Mi , Hahn Won-Ho , Park Suyeon , Lee Jung Eun , Yoo Young Bum , Ryoo Chung Ja
Published: October 2020

Spousal support may attenuate stress in breast cancer survivors and improve their health-related quality of life (HRQoL). However, there is limited evidence of a relationship between spousal support, stress, and HRQoL in Asian populations. The current study examined whether spousal support, adherence to the American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Survivors, and breastfeeding experience mediated or moderated the relationship between stress and HRQoL in Korean breast-cancer survivors. Between June 2016 and May 2018, 144 Korean women who survived breast cancer were recruited for the current cross-sectional study. Structured questionnaires and medical records were used to collect data. Structural equation modeling was used to examine mediating and moderating factors. Spousal support buffered the adverse effect of stress on HRQoL (β = −0.22 for stress→spousal support; β = 0.27 for spousal support→physical HRQoL; β = 0.40 for spousal support→mental HRQoL). We found that adherence to ACS guidelines moderated the association between stress and HRQoL (β = −0.14 for stress→mental HRQoL in high ACS adherence; β = −0.79 for stress→mental HRQoL in low ACS adherence). Moreover, beta coefficients were −0.22 for stress→mental HRQoL in women with breastfeeding experience, and −0.71 in those without breastfeeding experience. In conclusion, spousal support mediated the association between stress and HRQoL and this association was moderated by both adherence to ACS guidelines and breastfeeding experience.
Snacks and The City: Unexpected Low Sales of an Easy-Access, Tasty, and Healthy Snack at an Urban Snacking Hotspot
Authors: Schlinkert Caroline , Gillebaart Marleen , Benjamins Jeroen , Poelman Maartje P. , de Ridder Denise
Published: October 2020

While many people declare an intention to eat and snack more healthily, a large body of research has found that these intentions often do not translate into actual behavior. This failure to fulfil intentions is regularly attributed to the obesogenic environment, on which basis it is assumed that changing the food environment may lead to more healthy snacking behavior. To test this premise in real life practice, the present research project investigated whether making a healthy snack easy-to-access in an urban environment characterized by unhealthy snacking would support people in their intentions of purchasing more healthy snacks. The urban snack project consisted of three phases. In Phase 1, a hotspot location for unhealthy snacking was determined by using a Global Positioning System to track people’s snacking locations and a survey to verify the location. In Phase 2, an attractive snack was developed that met consumers’ criteria of what constituted a healthy and tasty snack, together with corresponding branding that also included a small food truck from which to sell the newly developed snacks. In Phase 3, the snack was sold from the food truck located at the previously determined unhealthy snacking hotspot. We counted the number of snacks sold and canvassed people’s opinions about the snack and its branding, finding that in spite of people’s appreciation for the snack, the food truck, and the branding, actual sales of the snack were very low. In the Discussion, we name predominant eating and purchasing habits as possible reasons for these low sales. Future research could focus on placing the healthy snack directly beside people’s habitual snack purchase location to ensure that the new choice gets better recognized. Overall, the findings suggest that merely placing healthy snacks more prominently in people’s food environment is not sufficient to lead people to snack more healthily.
Therapeutic Nature Activities: A Step Toward the Labor Market for Traumatized Refugees
Authors: Poulsen Dorthe Varning , Pálsdóttir Anna María , Christensen Sasja Iza , Wilson Lotta , Uldall Sigurd Wiingaard
Published: October 2020

Background: Globally, the number of refugees is growing. For many refugees, entering the labor market in their new country of residence is challenging. Some remain forever dependent on welfare services, and this not only weakens their chances of integration, but also harms their health and well-being. Methods: This qualitative single case study focused on a group of war-stricken refugees in Denmark. The study investigated the impact of an eight-month horticultural vocational program aimed at improving their ability to complete an education program or to work. A total of 29 interviews were conducted and analyzed using the interpretative phenomenological analysis (IPA) method. Results: The natural environment in the eco-village evoked a feeling of safety as well as positive memories in the participants, in contrast to the traumatic memories they had of their flight. Horticultural activities and the positive and respectful attitude from staff initiated a recovery process. New skills were achieved at an individual pace, and feelings of isolation decreased. These findings can be implicated in future interventions.
Global Analyses of Expressed Piwi-Interacting RNAs in Gastric Cancer
Authors: Vinasco-Sandoval Tatiana , Moreira Fabiano Cordeiro , F. Vidal Amanda , Pinto Pablo , Ribeiro-dos-Santos André M. , Cruz Rebecca L. S. , Fonseca Cabral Gleyce , Anaissi Ana K. M. , Lopes Katia de Paiva , Ribeiro-dos-Santos Arthur , Demachki Samia , de Assumpção Paulo Pimentel , Ribeiro-dos-Santos Ândrea , Santos Sidney
Published: October 2020

Gastric cancer (GC) represents a notable amount of morbidity and mortality worldwide. Understanding the molecular basis of CG will offer insight into its pathogenesis in an attempt to identify new molecular biomarkers to early diagnose this disease. Therefore, studies involving small non-coding RNAs have been widely explored. Among these, PIWI-interacting RNAs (piRNAs) are an emergent class that can play important roles in carcinogenesis. In this study, small-RNA sequencing was used to identify the global piRNAs expression profile (piRNome) of gastric cancer patients. We found 698 piRNAs in gastric tissues, 14 of which were differentially expressed (DE) between gastric cancer (GC), adjacent to gastric cancer (ADJ), and non-cancer tissues (NC). Moreover, three of these DE piRNAs (piR-48966*, piR-49145, piR-31335*) were differently expressed in both GC and ADJ samples in comparison to NC samples, indicating that the tumor-adjacent tissue was molecularly altered and should not be considered as a normal control. These three piRNAs are potential risk biomarkers for GC, especially piR-48966* and piR-31335*. Furthermore, an in-silico search for mRNAs targeted by the differentially expressed piRNAs revealed that these piRNAs may regulate genes that participate in cancer-related pathways, suggesting that these small non-coding RNAs may be directly and indirectly involved in gastric carcinogenesis.
The Role of Zinc in Copper Homeostasis of Aspergillus fumigatus
Authors: Kang Suzie , Seo Hyewon , Moon Hee-Soo , Kwon Joon-Ho , Park Yong-Sung , Yun Cheol-Won
Published: October 2020

Copper is an essential metal ion that performs many physiological functions in living organisms. Deletion of Afmac1, which is a copper-responsive transcriptional activator in A. fumigatus, results in a growth defect on aspergillus minimal medium (AMM). Interestingly, we found that zinc starvation suppressed the growth defect of the Δafmac1 strain on AMM. In addition, the growth defect of the Δafmac1 strain was recovered by copper supplementation or introduction of the CtrC gene into the Δafmac1 strain. However, chelation of copper by addition of BCS to AMM failed to recover the growth defect of the Δafmac1 strain. Through Northern blot analysis, we found that zinc starvation upregulated CtrC and CtrA2, which encode membrane copper transporters. Interestingly, we found that the conserved ZafA binding motif 5′-CAA(G)GGT-3′ was present in the upstream region of CtrC and CtrA2 and that mutation of the binding motif led to failure of ZafA binding to the upstream region of CtrC and upregulation of CtrC expression under zinc starvation. Furthermore, the binding activity of ZafA to the upstream region of CtrC was inversely proportional to the zinc concentration, and copper inhibited the binding of ZafA to the upstream region of CtrC under a low zinc concentration. Taken together, these results suggest that ZafA upregulates copper metabolism by binding to the ZafA binding motif in the CtrC promoter region under low zinc concentration, thus regulating copper homeostasis. Furthermore, we found that copper and zinc interact in cells to maintain metal homeostasis.
On the Anti-Corrosion Property of Dry-Gel-Conversion-Grown MFI Zeolite Coating on Aluminum Alloy
Authors: Tsai Shang-Tien , ChangJean Wen-Chyuan , Huang Lin-Yi , Tsai Tseng-Chang
Published: October 2020

MFI zeolite film coated on AA6061 alloy was prepared from fumed silica modified with/without n-octyldecyltrimethoxysilane (ODS) by means of dry gel conversion (DGC) method. The DGC-grown MFI zeolite film could form a strong barrier to protect AA6061 surface against the corrosion from NaCl solution. By using fumed silica as a starting material, the hydrophilicity and anti-corrosion capability of the MFI zeolite film declined with increasing humidity in the DGC synthesis. By silanization with ODS, the surface hydrophobicity of the MFI zeolite film increased, leading to substantial enhancement in anti-corrosion capability. On the other hand, MFI film grown from ODS-modified fumed silica exhibited low hydrophilicity and a much improved anti-corrosion protection property by four orders of magnitude, even stronger than the ODS post-treated MFI film. The strong anti-corrosion capability is attributed to the “thick layer” surface hydrophobicity of zeolite crystal.
Magnetorheological Elastomers: Fabrication, Characteristics, and Applications
Authors: Kang Sung , Choi Kisuk , Nam Jae-Do , Choi Hyoung
Published: October 2020

Magnetorheological (MR) elastomers become one of the most powerful smart and advanced materials that can be tuned reversibly, finely, and quickly in terms of their mechanical and viscoelastic properties by an input magnetic field. They are composite materials in which magnetizable particles are dispersed in solid base elastomers. Their distinctive behaviors are relying on the type and size of dispersed magnetic particles, the type of elastomer matrix, and the type of non-magnetic fillers such as plasticizer, carbon black, and crosslink agent. With these controllable characteristics, they can be applied to various applications such as vibration absorber, isolator, magnetoresistor, and electromagnetic wave absorption. This review provides a summary of the fabrication, properties, and applications of MR elastomers made of various elastomeric materials.
Effect of Sand Fines Concentration on the Erosion-Corrosion Mechanism of Carbon Steel 90° Elbow Pipe in Slug Flow
Authors: Khan Rehan , H. Ya Hamdan , Pao William , Majid Mohd Amin Abd , Ahmed Tauseef , Ahmad Amir , Alam Mohammad Azad , Azeem M. , Iftikhar Hassan
Published: October 2020

Erosion-corrosion of elbow configurations has recently been a momentous concern in hydrocarbon processing and transportation industries. The carbon steel 90° elbows are susceptible to the erosion-corrosion during the multiphase flow, peculiarly for erosive slug flows. This paper studies the erosion-corrosion performance of 90° elbows at slug flow conditions for impact with 2, 5, and 10 wt.% sand fines concentrations on AISI 1018 carbon steel exploiting quantitative and qualitative analyses. The worn surface analyses were effectuated by using laser confocal and scanning electron microscopy. The experiment was conducted under air and water slug flow containing sand fines of 50 µm average size circulated in the closed flow loop. The results manifest that with the increase of concentration level, the erosion-corrosion magnitude increases remarkably. Sand fines instigate the development of perforation sites in the form of circular, elongated, and coalescence pits at the elbow downstream and the corrosion attack is much more obvious with the increase of sand fines concentration. Another congruent finding is that cutting and pitting corrosion as the primitive causes of material degradation, the 10 wt.% sand fines concentration in carrier phase increases the erosion-corrosion rate of carbon steel up to 93% relative to the 2 wt.% sand fines concentration in slug flow.
A Review on Natural Fiber-Reinforced Geopolymer and Cement-Based Composites
Authors: Camargo Marfa , Adefrs Taye Eyerusalem , Roether Judith , Tilahun Redda Daniel , Boccaccini Aldo
Published: October 2020

The use of ecological materials for building and industrial applications contributes to minimizing the environmental impact of new technologies. In this context, the cement and geopolymer sectors are considering natural fibers as sustainable reinforcement for developing composites. Natural fibers are renewable, biodegradable, and non-toxic, and they exhibit attractive mechanical properties in comparison with their synthetic fiber counterparts. However, their hydrophilic character makes them vulnerable to high volumes of moisture absorption, thus conferring poor wetting with the matrix and weakening the fiber–matrix interface. Therefore, modification and functionalization strategies for natural fibers to tailor interface properties and to improve the durability and mechanical behavior of cement and geopolymer-based composites become highly important. This paper presents a review of the physical, chemical and biological pre-treatments that have been performed on natural fibers, their results and effects on the fiber–matrix interface of cement and geopolymer composites. In addition, the degradation mechanisms of natural fibers used in such composites are discussed. This review finalizes with concluding remarks and recommendations to be addressed through further in-depth studies in the field.
Synthesis, Characterization and Catalytic Activity of Ternary Oxide Catalysts Using the Microwave-Assisted Solution Combustion Method
Authors: Frikha Kawthar , Limousy Lionel , Bouaziz Jamel , Chaari Kamel , Bennici Simona
Published: October 2020

Ni−Co−Al, Ni−Cu−Al and Co−Cu−Al ternary oxide catalysts, with a fixed 5 wt% transition metal loading, were prepared by the microwave-assisted solution combustion method and tested in CO oxidation. The bulk and surface properties of the catalysts were investigated, using XRD, N2 adsorption–desorption, SEM, XPS and TEM techniques. XRD, XPS and TEM results revealed that nickel and cobalt were present as spinels on the surface and in the bulk. Differently, copper was preferentially present in “bulk-like” CuO-segregated phases. No interaction between the couples of transition metal species was detected, and the introduction of Cu-containing precursors into the Ni−Al or Co−Al combustion systems was not effective in preventing the formation of NiAl2O4 and CoAl2O4 spinels in the Ni− or Co-containing catalysts. Copper-containing catalysts were the most active, indicating that copper oxides are the effective active species for improving the CO oxidation activity.
Numerical Simulations of Destructive Tests of Cast Iron Columns Strengthened with a CFRP Coating
Authors: Marcinowski Jakub , Różycki Zbigniew , Sakharov Volodymyr
Published: October 2020

In many cases, there is a need to reinforce the existing, sometimes very old, cast iron columns. The paper describes a proposed and completed reinforcement procedure using an external, thin coating (sleeve or jacket) made of composite (carbon fiber reinforced polymer—CFRP). The strengthening effect was verified in destructive tests performed on two original columns (without reinforcement) and two other, identical columns strengthened by means of the proposed technique. Due to the expected very high load capacity of the axially loaded column, the test rig was designed to allow the application of the force on a big eccentricity. For this purpose a special base was designed and fabricated. Destructive tests have confirmed the high effectiveness of the adopted strengthening technique. The main objective of the present paper is a numerical confirmation of experimental results. All material parameters required in the numerical model were determined in laboratory tests. Simulation was performed using the finite element method—based on two systems, COSMOS/M and Simulia Abaqus. Numerical models were validated on results of the analytical assessment of stresses presented in the paper as well. Results of numerical simulations made on nonlinear models were compared with the experimental results. Destruction mechanisms observed in the experiments were confirmed in performed numerical simulations.
Study of Industrial Grade Thermal Insulation at Elevated Temperatures
Authors: Gunnarshaug Amalie , Metallinou Maria Monika , Log Torgrim
Published: October 2020

Thermal insulation is used for preventing heat losses or heat gains in various applications. In industries that process combustible products, inorganic-materials-based thermal insulation may, if proven sufficiently heat resistant, also provide heat protection in fire incidents. The present study investigated the performance and breakdown temperature of industrial thermal insulation exposed to temperatures up to 1200 °C, i.e., temperatures associated with severe hydrocarbon fires. The thermal insulation properties were investigated using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and by heating 50 mm cubes in a muffle furnace to temperatures in the range of 600 to 1200 °C with a 30 min holding time. The room temperature thermal conductivity was also recorded after each heat treatment. Upon heating, the mineral-based oil dust binder was released at temperatures in the range of 300 to 500 °C, while the Bakelite binder was released at temperatures in the range of 850 to 960 °C. The 50 mm test cubes experienced increasing levels of sintering in the temperature range of 700 to 1100 °C. At temperatures above 1100 °C, the thermal insulation started degrading significantly. Due to being heat-treated to 1200 °C, the test specimen morphology was similar to a slightly porous rock and the original density of 140 kg/m3 increased to 1700 kg/m3. Similarly, the room temperature thermal conductivity increased from 0.041 to 0.22 W/m∙K. The DSC analysis confirmed an endothermic peak at about 1200 °C, indicating melting, which explained the increase in density and thermal conductivity. Recently, 350 kW/m2 has been set as a test target heat flux, i.e., corresponding to an adiabatic temperature of 1200 °C. If a thin layer of thermally robust insulation is placed at the heat-exposed side, the studied thermal insulation may provide significant passive fire protection, even when exposed to heat fluxes up to 350 kW/m2. It is suggested that this is further analysed in future studies.
Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation
Authors: Ryan Melissa K. , Oliviero Sara , Costa Maria Cristiana , Wilkinson J. Mark , Dall’Ara Enrico
Published: October 2020

Osteoarthritis (OA) is a chronic disease, affecting approximately one third of people over the age of 45. Whilst the etiology and pathogenesis of the disease are still not well understood, mechanics play an important role in both the initiation and progression of osteoarthritis. In this study, we demonstrate the application of stepwise compression, combined with microCT imaging and digital volume correlation (DVC) to measure and evaluate full-field strain distributions within osteoarthritic femoral heads under uniaxial compression. A comprehensive analysis showed that the microstructural features inherent in OA bone did not affect the level of uncertainties associated with the applied methods. The results illustrate the localization of strains at the loading surface as well as in areas of low bone volume fraction and subchondral cysts. Trabecular thickness and connectivity density were identified as the only microstructural parameters with any association to the magnitude of local strain measured at apparent yield strain or the volume of bone exceeding yield strain. This work demonstrates a novel approach to evaluating the mechanical properties of the whole human femoral head in case of severe OA.
Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation
Authors: Shu Zhendan , Liu Qingmei , Xing Cuiping , Zhang Yafen , Zhou Yu , Zhang Jun , Liu Hong , Cao Minjie , Yang Xianwen , Liu Guangming
Published: October 2020

Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were established to explore the anti-allergic properties of viridicatol. On the basis of the mouse model, we found viridicatol to alleviate the allergy symptoms; decrease the levels of specific immunoglobulin E, mast cell protease-1, histamine, and tumor necrosis factor-α; and promote the production of interleukin-10 in the serum. The treatment of viridicatol also downregulated the population of B cells and mast cells (MCs), as well as upregulated the population of regulatory T cells in the spleen. Moreover, viridicatol alleviated intestinal villi injury and inhibited the degranulation of intestinal MCs to promote intestinal barrier repair in mice. Furthermore, the accumulation of Ca2+ in RBL-2H3 cells was significantly suppressed by viridicatol, which could block the activation of MCs. Taken together, these data indicated that deep-sea viridicatol may represent a novel therapeutic for allergic diseases.
Influence of the Accumulation of Unhealthy Eating Habits on Obesity in a General Japanese Population: The Hisayama Study
Authors: Ishida Yuki , Yoshida Daigo , Honda Takanori , Hirakawa Yoichiro , Shibata Mao , Sakata Satoko , Furuta Yoshihiko , Oishi Emi , Hata Jun , Kitazono Takanari , Ninomiya Toshiharu
Published: October 2020

Few studies have examined the association between the accumulation of unhealthy eating habits and the likelihood of obesity or central obesity in a general Japanese population. We examined this association in a sample of 1906 community-dwelling Japanese subjects (age: 40–74 years) who participated in a health check-up in 2014. A face-to-face questionnaire interview was conducted to collect information about three unhealthy eating habits, i.e., snacking, eating quickly, and eating late-evening meals. Obesity was defined as body mass index ≥25 kg/m2 and central obesity was defined as waist circumference ≥90 cm in men and ≥80 cm in women. The odds ratios (OR) were estimated by using a logistic regression analysis. Subjects with any one of the three eating habits had a significantly higher likelihood of obesity than those without that habit after adjusting for confounding factors. The multivariable-adjusted OR for obesity increased linearly with an increase in the number of accumulated unhealthy eating habits (p for trend < 0.001). Similar associations were observed for central obesity. Our findings suggest that modifying each unhealthy eating habit and avoiding an accumulation of multiple unhealthy eating habits might be important to reduce the likelihood of obesity.
Metabolomic Associations with Serum Bone Turnover Markers
Authors: Bellissimo Moriah P. , Roberts Joseph L. , Jones Dean P. , Liu Ken H. , Taibl Kaitlin R. , Uppal Karan , Weitzmann M. Neale , Pacifici Roberto , Drissi Hicham , Ziegler Thomas R. , Alvarez Jessica A.
Published: October 2020

Bone is a dynamic tissue that is in a constant state of remodeling. Bone turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides of type I collagen (CTX), provide sensitive measures of bone formation and resorption, respectively. This study used ultra-high-resolution metabolomics (HRM) to determine plasma metabolic pathways and targeted metabolites related to the markers of bone resorption and formation in adults. This cross-sectional clinical study included 34 adults (19 females, mean 27.8 years), without reported illnesses, recruited from a US metropolitan area. Serum BTM levels were quantified by an ELISA. Plasma HRM utilized dual-column liquid chromatography and mass spectrometry to identify metabolites and metabolic pathways associated with BTMs. Metabolites significantly associated with P1NP (p < 0.05) were significantly enriched in pathways linked to the TCA cycle, pyruvate metabolism, and metabolism of B vitamins important for energy production (e.g., niacin, thiamin). Other nutrition-related metabolic pathways associated with P1NP were amino acid (proline, arginine, glutamate) and vitamin C metabolism, which are important for collagen formation. Metabolites associated with CTX levels (p < 0.05) were enriched within lipid and fatty acid beta-oxidation metabolic pathways, as well as fat-soluble micronutrient pathways including, vitamin D metabolism, vitamin E metabolism, and bile acid biosynthesis. P1NP and CTX were significantly related to microbiome-related metabolites (p < 0.05). Macronutrient-related pathways including lipid, carbohydrate, and amino acid metabolism, as well as several gut microbiome-derived metabolites were significantly related to BTMs. Future research should compare metabolism BTMs relationships reported here to aging and clinical populations to inform targeted therapeutic interventions.
Inconsistencies in the Nutrition Management of Glutaric Aciduria Type 1: An International Survey
Authors: Bernstein Laurie , Coughlin Curtis R. , Drumm Morgan , Yannicelli Steven , Rohr Fran
Published: October 2020

Glutaric aciduria type 1 (GA-1) is a cerebral organic aciduria characterized by striatal injury and progressive movement disorder. Nutrition management shifted from a general restriction of intact protein to targeted restriction of lysine and tryptophan. Recent guidelines advocate for a low-lysine diet using lysine-free, tryptophan-reduced medical foods. GA-1 guideline recommendations for dietary management of patients over the age of six are unclear, ranging from avoiding excessive intake of intact protein to counting milligrams of lysine intake. A 22–question survey on the nutrition management of GA-1 was developed with the goal of understanding approaches to diet management for patients identified by newborn screening under age six years compared to management after diet liberalization, as well as to gain insight into how clinicians define diet liberalization. Seventy-six responses (25% of possible responses) to the survey were received. Nutrition management with GA-1 is divergent among surveyed clinicians. There was congruency among survey responses to the guidelines, but there is still uncertainty about how to counsel patients on diet optimization and when diet liberalization should occur. Ongoing clinical research and better understanding of the natural history of this disease will help establish stronger recommendations from which clinicians can best counsel families.
Grape Seed Proanthocyanidin Extract Prevents Bone Loss via Regulation of Osteoclast Differentiation, Apoptosis, and Proliferation
Authors: Kwak Sung Chul , Cheon Yoon-Hee , Lee Chang Hoon , Jun Hong Young , Yoon Kwon-Ha , Lee Myeung Su , Kim Ju-Young
Published: October 2020

Dietary procyanidin has been shown to be an important bioactive component that regulates various pharmacological activities to maintain metabolic homeostasis. In particular, grape seed proanthocyanidin extract (GSPE) is a commercially available medicine for the treatment of venous and lymphatic dysfunction. This study aimed to investigate whether GSPE protects against lipopolysaccharide (LPS)-induced bone loss in vivo and the related mechanism of action in vitro. The administration of GSPE restored the inflammatory bone loss phenotype stimulated by acute systemic injection of LPS in vivo. GSPE strongly suppressed receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclast differentiation and bone resorption activity of mature osteoclasts by decreasing the RANKL-induced nuclear factor-κB transcription activity. GSPE mediates this effect through decreased phosphorylation and degradation of NF-κB inhibitor (IκB) by IκB kinaseβ, subsequently inhibiting proto-oncogene cellular Fos and nuclear factor of activated T cells. Additionally, GSPE promotes osteoclast proliferation by increasing the phosphorylation of components of the Akt and mitogen-activated protein kinase signaling pathways and it also inhibits apoptosis by decreasing the activity of caspase-8, caspase-9, and caspase-3, as corroborated by a decrease in the Terminal deoxynucleotidyl transferase dUTP nick end labeling -positive cells. Our study suggests a direct effect of GSPE on the proliferation, differentiation, and apoptosis of osteoclasts and reveals the mechanism responsible for the therapeutic potential of GSPE in osteoclast-associated bone metabolism disease.
The Social Stratification of Availability, Affordability, and Consumption of Food in Families with Preschoolers in Addis Ababa; The EAT Addis Study in Ethiopia
Authors: Abdelmenan Semira , Berhane Hanna Y. , Jirström Magnus , Trenholm Jill , Worku Alemayehu , Ekström Eva-Charlotte , Berhane Yemane
Published: October 2020

The aim of this study was to understand the quality of diet being consumed among families in Addis Ababa, and to what extent social stratification and perceptions of availability and affordability affect healthy food consumption. Data were collected from 5467 households in a face-to-face interview with mothers/caretakers and analyzed using mixed effect logistic regression models. All family food groups, except fish were perceived to be available by more than 90% of the participants. The food groups cereals/nuts/seeds, other vegetables, and legumes were considered highly affordable (80%) and were the most consumed (>75%). Households with the least educated mothers and those in the lowest wealth quintile had the lowest perception of affordability and also consumption. Consumption of foods rich in micronutrients and animal sources were significantly higher among households with higher perceived affordability, the highest wealth quintile, and with mothers who had better education. Households in Addis Ababa were generally seen to have a monotonous diet, despite the high perceived availability of different food groups within the food environment. There is a considerable difference in consumption of nutrient-rich foods across social strata, hence the cities food policies need to account for social differences in order to improve the nutritional status of the community.
The Benefits of Flavonoids in Diabetic Retinopathy
Authors: Matos Ana L. , Bruno Diogo F. , Ambrósio António F. , Santos Paulo F.
Published: October 2020

Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading cause of legal blindness among adults of working age in developed countries. After 20 years of diabetes, almost all patients suffering from type I diabetes mellitus and about 60% of type II diabetics have DR. Several studies have tried to identify drugs and therapies to treat DR though little attention has been given to flavonoids, one type of polyphenols, which can be found in high levels mainly in fruits and vegetables, but also in other foods such as grains, cocoa, green tea or even in red wine. Flavonoids have anti-inflammatory, antioxidant and antiviral effects. Since it is known that diabetes induces oxidative stress and inflammation in the retina leading to neuronal death in the early stages of the disease, the use of these compounds can prove to be beneficial in the prevention or treatment of DR. In this review, we summarize the molecular and cellular effects of flavonoids in the diabetic retina.
Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells
Authors: Garrido Maritza P. , Salvatierra Renato , Valenzuela-Valderrama Manuel , Vallejos Christopher , Bruneau Nicole , Hernández Andrea , Vega Margarita , Selman Alberto , Quest Andrew F. G. , Romero Carmen
Published: October 2020

Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute to EOC progression by increasing the expression of c-MYC, survivin and vascular endothelial growth factor (VEGF) along with a decrease in microRNAs (miR) 23b and 145. We previously reported that metformin prevents NGF-induced proliferation and angiogenic potential of EOC cells. In this study, we sought to obtain a better understanding of the mechanism(s) by which metformin blocks these NGF-induced effects in EOC cells. Human ovarian surface epithelial (HOSE) and EOC (A2780/SKOV3) cells were stimulated with NGF and/or metformin to assess the expression of c-MYC, β-catenin, survivin and VEGF and the abundance of the tumor suppressor miRs 23b and 145. Metformin decreased the NGF-induced transcriptional activity of MYC and β-catenin/T-cell factor/lymphoid enhancer-binding factor (TCF-Lef), as well as the expression of c-MYC, survivin and VEGF in EOC cells, while it increased miR-23b and miR-145 levels. The preliminary analysis of ovarian biopsies from women users or non-users of metformin was consistent with these in vitro results. Our observations shed light on the mechanisms by which metformin may suppress tumour growth in EOC and suggest that metformin should be considered as a possible complementary therapy in EOC treatment.