bluuebunny/crossref_metadata_2025 huggingface dataset:
Difference in Immunogenic Responses to COVID-19 Vaccines in Patients With Cancer Receiving Chemotherapy Versus Nonchemotherapy Treatment
Authors: Tantiyavarong Walaipan , Sungkasubun Prakongboon , Chaiwiriyawong Worawit , Supavavej Archara , Limpawittayakul Piyarat , Weerasubpong Bowon , Siripaibun Jomtana , Phanthunane Chumut , Lamlertthon Wisut , Ungtrakul Teerapat , Tawinprai Kriangkrai , Tantiyavarong Pichaya , Samdaengpan Chayanee
Published: March 2023

PURPOSE

The COVID-19 pandemic has affected public health worldwide. The efficacy and safety of COVID-19 vaccines have been evaluated in the general population; however, data on patients with malignancies are limited.

METHODS

This prospective longitudinal observational cohort study was conducted between June and July 2021. Enrolled adult patients with cancer were divided into chemotherapy and nonchemotherapy groups. All participants were immunized with two doses of the ChAdOx1 nCoV-19 or CoronaVac COVID-19 vaccines. The primary outcome was a comparison of the immunogenicity (as assessed by spike protein [anti-S] immunoglobulin G [IgG] antibody titers) of two doses of COVID-19 vaccine in the chemotherapy and nonchemotherapy groups. The secondary outcomes included the anti-S IgG seroconversion rate and vaccine safety in both groups.

RESULTS

Among the 173 enrolled patients with solid cancer, after COVID-19 vaccination, the chemotherapy group had a significantly lower median anti-S IgG titer than the nonchemotherapy group (26 v 237 U/mL, P < .001). A statistically significant difference in anti-S IgG titer was found between groups vaccinated with CoronaVac (7 v 90 U/mL, P < .001), but no difference was found in those vaccinated with ChAdOx1 nCoV-19 (818 v 1061 U/mL, P = .075). The anti-S IgG seroconversion rate was significantly lower in the chemotherapy group than that in the nonchemotherapy group (78.9% v 96.5%, P = .001). No new or serious vaccine-related adverse events were reported.

CONCLUSION

Patients with solid cancer receiving a COVID-19 vaccine while undergoing chemotherapy had lower immunogenicity responses to vaccination than those who were vaccinated while undergoing nonchemotherapy treatment. No statistically significant difference was observed in the COVID-19 vaccine safety profiles between groups.
Comparing quantumness criteria
Authors: Martin Jérôme , Micheli Amaury , Vennin Vincent
Published: March 2023

Measuring the quantumness of a system can be done with a variety of methods. In this article we compare different criteria, namely quantum discord, Bell inequality violation and non-separability, for systems placed in a Gaussian state. When the state is pure, these criteria are equivalent, while we find that they do not necessarily coincide when decoherence takes place. Finally, we prove that these criteria are essentially controlled by the semi-minor axis of the ellipse representing the state's Wigner function in phase space.
The Progression of Pathophysiology of Moyamoya Disease
Authors: Chen Tongyu , Wei Wei , Yu Jin , Xu Shuangxiang , Zhang Jianjian , Li Xiang , Chen Jincao
Published: March 2023

Moyamoya disease (MMD) is a chronic steno-occlusive cerebrovascular disease that often leads to hemorrhagic and ischemic strokes; however, its etiology remains elusive. Surgical revascularization by either direct or indirect bypass techniques to restore cerebral hypoperfusion is the treatment of choice to date. This review aims to provide an overview of the current advances in the pathophysiology of MMD, including the genetic, angiogenic, and inflammatory factors related to disease progression. These factors may cause MMD-related vascular stenosis and aberrant angiogenesis in complex manners. With a better understanding of the pathophysiology of MMD, nonsurgical approaches that target the pathogenesis of MMD may be able to halt or slow the progression of this disease.
Spinal Venous Vascular Ectasia With Unusual presentation of Abdominal Pain: Case Report
Authors: Ramon Juan Fernando , Rairan Luis García , Usuga Valentina , Mejia Juan Andrés
Published: March 2023

BACKGROUND AND IMPORTANCE:

Spinal venous vascular ectasia associated with a low-flow fistula of paravertebral location is a very low-frequency entity. It usually manifests with myelopathy; however, in the present case, the symptomatology corresponded to thoracic radiculopathy, which can be difficult to diagnose and may be the cause of chronic pain refractory to analgesic management.

CLINICAL PRESENTATION:

An adult patient who consulted about a 1 year and a half of flank pain refractory to analgesic management and hypoesthesia on palpation in the left T8 dermatome, therefore, pain of radicular origin was suspected. MRI of the thoracic spine was requested, showing an image suggestive of vascular malformation at the level of T8. After identification of the lesion, the patient was taken to spinal angiography to delimit the vascular malformation, finding an image suggestive of spinal venous vascular ectasia associated with a low-flow fistula of paravertebral location at T8. Subsequently, the case was discussed by a multidisciplinary team that established endovascular embolization as the best option for treatment. Thus, achieving complete occlusion of the lesion without complications and a slow improvement of the symptoms.

CONCLUSION:

Spinal venous vascular ectasia associated with a low-flow fistula of paravertebral location is a very low-frequency entity that despite manifesting with myelopathy in some cases may generate radicular irritative symptoms and is differentiated from other lesions by its unusual location in spinal angiography.
Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth
Authors: Lemmetyinen Toni T. , Viitala Emma W. , Wartiovaara Linnea , Kaprio Tuomas , Hagström Jaana , Haglund Caj , Katajisto Pekka , Wang Timothy C. , Domènech-Moreno Eva , Ollila Saara
Published: March 2023

Growth factors secreted by stromal fibroblasts regulate the intestinal epithelium. Stroma-derived epidermal growth factor (EGF) family ligands are implicated in epithelial regeneration and tumorigenesis, but their specific contributions and associated mechanisms remain unclear. Here, we use primary intestinal organoids modeling homeostatic, injured and tumorigenic epithelia to assess how the fibroblast-derived EGF family ligands neuregulin 1 (NRG1) and epiregulin (EREG) regulate the intestinal epithelium. NRG1 was expressed exclusively in the stroma, robustly increased crypt budding and protected intestinal epithelial organoids from radiation-induced damage. NRG1 also induced regenerative features in the epithelium, including a fetal-like transcriptome, suppression of the Lgr5+ stem cell pool and remodeling of the epithelial actin cytoskeleton. Intriguingly, unlike EGF and EREG, NRG1 failed to support the growth of pre-tumorigenic intestinal organoids lacking the tumor suppressor Apc, commonly mutated in human colorectal cancer (CRC). Interestingly, high expression of stromal NRG1 was associated with improved survival in CRC cohorts, suggesting a tumor-suppressive function. Our results highlight the power of stromal NRG1 in transcriptional reprogramming and protection of the intestinal epithelium from radiation injury without promoting tumorigenesis.
HuR modulation counteracts lipopolysaccharide response in murine macrophages
Authors: Bonomo Isabelle , Assoni Giulia , La Pietra Valeria , Canarutto Giulia , Facen Elisa , Donati Greta , Zucal Chiara , Genovese Silvia , Micaelli Mariachiara , Pérez-Ràfols Anna , Robbiati Sergio , Kontoyannis Dimitris L. , De Matteo Marilenia , Fragai Marco , Seneci Pierfausto , Marinelli Luciana , Arosio Daniela , Piazza Silvano , Provenzani Alessandro
Published: March 2023

Lipopolysaccharide (LPS) exposure to macrophages induces an inflammatory response, which is regulated at the transcriptional and post-transcriptional levels. HuR (ELAVL1) is an RNA-binding protein that regulates cytokines and chemokines transcripts containing AU/U-rich elements (AREs) and mediates the LPS-induced response. Here, we show that small-molecule tanshinone mimics (TMs) inhibiting HuR–RNA interaction counteract LPS stimulus in macrophages. TMs exist in solution in keto-enolic tautomerism, and molecular dynamic calculations showed the ortho-quinone form inhibiting binding of HuR to mRNA targets. TM activity was lost in vitro by blocking the diphenolic reduced form as a diacetate, but resulted in prodrug-like activity in vivo. RNA and ribonucleoprotein immunoprecipitation sequencing revealed that LPS induces a strong coupling between differentially expressed genes and HuR-bound genes, and TMs reduced such interactions. TMs decreased the association of HuR with genes involved in chemotaxis and immune response, including Cxcl10, Il1b and Cd40, reducing their expression and protein secretion in primary murine bone marrow-derived macrophages and in an LPS-induced peritonitis model. Overall, TMs show anti-inflammatory properties in vivo and suggest HuR as a potential therapeutic target for inflammation-related diseases.
Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models
Authors: Sai Kazuhito , Nakanishi Aoi , Scofield Kimberly M. , Tokarz Debra A. , Linder Keith E. , Cohen Todd J. , Ninomiya-Tsuji Jun
Published: March 2023

Neuroinflammation is causally associated with Alzheimer's disease (AD) pathology. Reactive glia cells secrete various neurotoxic factors that impair neuronal homeostasis eventually leading to neuronal loss. Although the glial activation mechanism in AD has been relatively well studied, how it perturbs intraneuronal signaling, which ultimately leads to neuronal cell death, remains poorly understood. Here, we report that compound stimulation with the neurotoxic factors TNF and glutamate aberrantly activates neuronal TAK1 (also known as MAP3K7), which promotes the pathogenesis of AD in mouse models. Glutamate-induced Ca2+ influx shifts TNF signaling to hyper-activate TAK1 enzymatic activity through Ca2+/calmodulin-dependent protein kinase II, which leads to necroptotic cellular damage. Genetic ablation and pharmacological inhibition of TAK1 ameliorated AD-associated neuronal loss and cognitive impairment in the AD model mice. Our findings provide a molecular mechanism linking cytokines, Ca2+ signaling and neuronal necroptosis in AD.
Case Report: Competitive causes of death: a case report of non-mutilated but fatal traumatic railway injury
Authors: Purnamaningsih Sari Nur Indahty , Perwira Satria , Ramadhani Prasillia , Yudianto Ahmad
Published: March 2023

Background: Railway-related accidents can cause severe injuries, and, most of the time, death. In a country with frequent railway-related accidents, a complete autopsy is vital to determine the cause and mechanism of death, reconstruct the events before death, and identify the victim. It is also essential to determine whether the deceased died by suicide or homicide. This article reports an autopsy of a non-identified victim from a train crash with two fatal injuries. In addition, we reported the challenges in establishing the cause and manner of death.

Case presentation: A man was hit by a Pertamina train on Tuesday, 19 July 2022, at 00:24 West Indonesian Time (UTC+07:00), and this was reported to the police for investigation. The body was then examined at Dr. Soetomo General Academic Hospital by a forensic expert. The external examination suggested the presence of abrasions on the face, waist, and all four limbs, lacerations on the face and right earlobe, and open head fractures. In an internal examination, skull-base fractures, fourth and sixth right rib fractures, bleeding in the chest cavity, shrinking lungs, lacerations to the liver and lower right and left lungs, and blood infiltration in the chest cavity wall muscles and scalp muscles were found. The pneumothorax test was positive on the left chest but negative for heart air embolism. Investigation of the base of the skull revealed the presence of fractures.

Conclusions: Determining the cause of death in a patient with multiple injuries was challenging and required a thorough investigation. Pneumothorax and air embolism could be the primary cause of death and their presence had to be investigated. Fractures of the base of the skull were established as the cause of death. According to the investigations at the crime scene and the injury profile, suicide was concluded as the manner of death.
Data presentation of results from randomized cancer clinical trials. The case for trials in advanced cervical cancer. A critical appraisal.
Authors: Duenas Gonzalez Alfonso , Coronel Jaime , Cabrera-Galeana Paula , Candelaria Myrna , Cano-Blanco Claudia
Published: March 2023

In the last four decades, median survival has increased in advanced cervical cancer from 7.1 with single-agent cisplatin to 24 months with doublet chemotherapy plus bevacizumab plus pembrolizumab. Coinciding with the irruption of targeted therapy, we observe higher pricing of novel cancer drugs and results presentation aimed to positively impact the audience. The first could result in poor drug affordability and financial toxicity, while the second can give patients a magnified sense of progress. In this review, we briefly comment on study designs that may favor obtaining positive results but, most notably, how results are presented pertaining the latest randomized clinical trials in advanced cervical cancer.  We found that survival results are expressed in Hazard Risk (HR) reductions but communicated as a Relative Risk (RR) reduction for death. The HR of the control to the experimental regimen is given by exp[β]. An HR of 0.7 means an HR reduction of 30%. Risk reduction derived from HR may lead to a belief that the intervention can eliminate the chance of the event occurring, but decreased HR means a reduction in the speed of the event to happen, not the chances to occur. On the contrary, the "risk reduction" based on RR means that patients have less chance of having the event because RR is a binary measure (alive or dead). Further, Absolute Risks and Number-To-Treat (NNT), in addition to Relative Risk, are omitted. The issue of how the results of cancer clinical trials are presented deserves open discussion. After all, it is the patient's right to make an informed decision for embarking on any cancer treatment.
Solving Educational and Applied Engineering and Construction Problems by Computer Graphics Methods
Authors: Verhoturova E.
Published: March 2023

The purpose of this study is to develop an algorithm for solving educational computational and graphic work from a cycle of constructive tasks of engineering and construction design (construction graphics) by computer geometric modeling in the environment of the domestic nanoCAD program. Algorithmization of the solution of the problem was carried out on the example of a training task from the cycle of graphic works in the course "Engineering and computer graphics", which is performed by students in the first semester and is the basis for solving problems of engineering and construction design. It is shown that the use of computer geometric modeling methods by means of modern software products makes it possible to speed up the process of solving a problem, simplify the calculation of the necessary data and visualize the results, which together contribute to an increase in the didactic effect and mastering the learning competencies necessary in future professional activities. Computer geometric modeling contributes to the understanding of the principles of modern information technologies, and also instills the skills to use them to solve more complex educational problems and tasks of future professional activity. Thus, the application of the proposed algorithm of computer geometric modeling in solving educational and applied problems within the framework of the training course "Engineering and Computer Graphics" in the preparation of students of engineering and construction profile, as well as in the performance of research and design activities is appropriate.
Features and directions of development for control quality and acceptance of material resources for objects of the oil and gas companies
Authors: Siutin Denis , Kutsenko Svetlana
Published: March 2023

IProject management and sustainable development are ones of the most important concepts that have gained great popularity in the scientific community in recent years. The need to integrate sustainability into project management is increasing every year changing the requirements for project managers` competencies.

Despite of the growing scientific interest in this topic, there is a small number of research papers that consider the impact of the concept of sustainability on the competences of a project manager. Thus, the purpose of this study is to identify the most important knowledge, skills and abilities and personal qualities needed by project managers for successful sustainable project management. The research is based on the analysis of the sources of scientific literature, international, and national standards in the field of project management.

The results showed that over the past 5 years the project manager profession has undergone significant changes, and in order to achieve sustainability project managers need to develop new professional competencies based on knowledge, skills and abilities, and personal qualities.
Multiple rib fractures, pleural effusion and right-sided diaphragmatic herniation of the colon into the chest associated with chronic cough after COVID-19
Authors: Chetana Shanmukhappa Sanjana , Malik Muhammad Ahmed , Akula Navya , Shaukat Fahd
Published: March 2023

Rib fractures are an infrequent consequence of severe cough. In some patients, undetected rib fractures can lead to life-threatening outcomes. The case of a 73-year-old man who presented with shortness of breath and a worsening dry cough from a SARS-CoV-2 infection for 4 weeks is described. In the emergency department, he was found to be hypoxic and hypotensive. Imaging studies revealed a large right pleural effusion, multiple rib fractures, and right-sided herniation of the colon into the chest. He was admitted to the cardiothoracic intensive care unit where he underwent a flexible bronchoscopy, right video-assisted thoracoscopic surgery, evacuation of a haemothorax, complete decortication, and repair of a diaphragmatic hernia. This case is an unusual presentation of an amalgamation of rare complications resulting from an unrelenting, poorly controlled SARS-CoV-2 infection cough that prompted rapid recognition and swift action.
Pengembangan Sistem E-Lapor untuk Meningkatkan Kualitas Pengelolaan Data Perumahan, Prasarana, Sarana dan Utilitas (PSU) di Kabupaten Sidoarjo
Authors: Ariastita Putu Gde , Septanaya I Dewa Made Frendika , Koswara Arwi Yudhi , Tucunan Karina Pradinie , Raharjo Agus Budi , Stefanugroho Placidus Kristadi
Published: March 2023

Kabupaten Sidoarjo menjadi lokasi pilihan utama bagi pengembang untuk membangun perumahan di wilayah metropolitan Surabaya. Pembangunan perumahan formal berkembang dengan pesat dan dampaknya sektor properti menjadi tulang punggung perekonomian di Kabupaten Sidoarjo. Namun, masalah muncul karena mayoritas pengembang belum atau tidak menyerahkan aset prasarana, sarana dan utilitas (PSU) perumahannya ke pemerintah daerah sebagaimana yang diamanatkan dalam Peraturan Menteri dalam Negeri No.9 tahun 2009 dan Peraturan Bupati Kabupaten Sidoarjo No.16 tahun 2017 serta No.10 tahun 2019. Dengan adanya permasalahan ini, sistem E-Lapor dibuat untuk mengelola isu PSU perumahan di Kabupaten Sidoarjo. Sistem ini secara teknis dikembangkan dalam bentuk web dengan memanfaatkan kerangka kerja Code Igniter dan sistem database MySQL. Hasilnya, sistem E-Lapor dapat mempermudah pemerintah Kabupaten Sidoarjo untuk melakukan kegiatan pemantauan, pencegahan dan penindakan, khususnya kepada pengembang yang tidak tertib dan taat dalam menyediakan PSU di lokasi perumahannya. Selain itu, bank data E-Lapor juga bisa dimanfaatkan untuk mengembangkan fitur lain dalam sistem cerdas E-Pengelolaan aset PSU perumahan di Kabupaten Sidoarjo.
Peningkatan Pendapatan UMKM di Kabupaten Lumajang melalui Pendampingan Kemasan dan Pemasaran Produk
Authors: Soedarso Soedarso , Utomo Christiono , Suryani Adi , Endarko Endarko , Ahmad Imam Safawi
Published: March 2023

Beberapa hal yang menjadi permasalahan dari tumbuhnya usaha mikro, kecil dan menengah (UMKM) adalah masalah terkait kemasan, branding, dan strategi pemasaran. Mayoritas UMKM hanya berfokus pada produksi tanpa memikirkan media kemasan yang menarik pelanggan, mempromosikan produk, dan cara memasarkan produknya secara lebih luas. Permasalahan ini juga ditemukan pada pelaku UMKM di Kabupaten Lumajang. Maka perlu dilaksanakan kegiatan pelatihan dan pendampingan bagi UMKM untuk membuat desain kemasan produk dan pemasaran produk. Pendampingan kepada UMKM ini diharapkan dapat meningkatkan penjualan produk UMKM. Desain kemasan produk yang menarik akan meningkatkan minat konsumen untuk membeli produk UMKM. Pemanfaatan media sosial sebagai media pemasaran akan meningkatkan jumlah konsumen. Peningkatan penjualan produk UMKM akan berkorelasi dengan meningkatnya pendapatan UMKM. Sehingga pelaku UMKM dapat menjadi pengusaha yang inovatif, memiliki nilai tambah, berdaya saing tinggi, memperluas lapangan pekerjaan, serta memperluas dan memperkuat relasi.
Coding for Kids: Pengenalan Pemrograman untuk Anak Sekolah Dasar sebagai Literasi Digital Baru di Industri 4.0
Authors: Muklason Ahmad , Riksakomara Edwin , Mahananto Faizal , Djunaidy Arif , Vinarti Retno Aulia , Anggraeni Wiwik , Nurita Raras Tyas , Utamima Amalia , Fauzia Rahma , Theresia Laura Wilhelmina , Fikri Muhammad Ali , Propitadewa Hardhika , Habibah Jihaan Harvi , Prasetyo Jeremy Diaz , Permatasari Septica Tiara Indah , Risnina Nur Nindya , Tsaniyah Nazriyah Deni , Maulana Muhammad Daffa
Published: March 2023

Coding adalah sebuah cara untuk memberikan perintah pada komputer, aplikasi, telepon, atau website untuk melakukan sesuatu. Coding adalah keterampilan yang sangat penting dikuasai di era industri 4.0 dan perlu diajarkan sejak dini. Oleh karena itu, tujuan dari kegiatan pengabdian masyarakat ini adalah untuk memperkenalkan pemrograman bagi para guru dan siswa di Madrasah Ibtidaiyah (MI) Nasyrul Ulum 1 Grobogan. Metode pengumpulan data dalam kegiatan ini dilakukan dengan survei dan wawancara. Hasil dari survei untuk para guru dan siswa pasca pelatihan mengatakan bahwa belum ada yang pernah mempelajari pemrograman. Delapan dari sembilan guru merasa bahwa coding perlu diajarkan pada anak-anak dan tertarik untuk mengajarkannya. Secara keseluruhan, kegiatan pelatihan coding bagi para guru dan siswa MIS Nasyrul Ulum 1 dirasa baik, menyenangkan, berkesan, dan bermanfaat.
Pengembangan Ekosistem Halal Skema Self-Declare pada Kantin Departemen Teknik Sistem dan Industri Institut Teknologi Sepuluh Nopember Surabaya
Authors: Siswanto Nurhadi , Ridho Hafidz , Sholihah Mar'atus , Widyaningrum Retno , Pratiwi Atikah Aghdhi , Widodo Erwin
Published: March 2023

Kebutuhan akan produk halal merupakan hal yang krusial di Indonesia mengingat Indonesia adalah negara dengan populasi umat muslim terbesar di dunia. ITS melalui Pusat Kajian Halal memiliki program pendampingan untuk memfasilitasi UMKM untuk mendapatkan sertifikat halal. Kegiatan pengabdian masyarakat ini merupakan bagian dari program tersebut dengan sasaran yaitu pelaku usaha pada kantin Departemen Teknik Sistem dan Industri ITS. Terdapat empat tahapan yang dilakukan dalam kegiatan pengabdian masyarakat ini, yaitu pelaksanaan pelatihan kader penggerak halal, pendampingan penyusunan sistem jaminan halal, bimbingan teknis pengajuan sertifikat halal, dan serah terima pemasangan plakat logo halal. Manfaat yang dihasilkan dari kegiatan ini yaitu meningkatnya kesadaran masyarakat mengenai pentingnya jaminan produk halal, sehingga program pemerintah dan Pusat Kajian Halal ITS untuk mendorong sertifikasi halal pada UMKM dapat terlaksana.
Penerapan Konverter-kit Bahan Bakar Ganda untuk Mesin Kapal Nelayan di Kalanganyar Sidoarjo
Authors: Iswantoro Adhi , Ariana I Made , Semin Semin , Fathallah Aguk Zuhdi Muhammad , Cahyono Beny
Published: March 2023

Penggunaan bahan bakar minyak (BBM) di masyarakat untuk transportasi, termasuk nelayan masih sangat tinggi, sementara penggunaan bahan bakar gas (BBG) pada sektor transportasi masih tergolong rendah. Padahal BBG memiliki banyak keunggulan, yakni lebih murah dan lebih bersih dari segi emisinya. Ketergantungan pada satu jenis bahan bakar ini sangat berpengaruh pada kesiapan operasional kapal nelayan. Banyak nelayan yang terpaksa tidak mencari ikan karena harga BBM dianggap mahal atau terkadang tidak tersedia di pasaran. Salah satu cara menyelesaikan masalah tersebut adalah dengan adanya bahan bakar jenis lain selain BBM, yaitu BBG. Salah satu BBG yang bisa digunakan adalah Liqufied Petroleum Gas (LPG), karena relatif mudah didapatkan masyarakat. Penggunaan bahan bakar ganda antara LPG dan BBM bertujuan agar konsumsi BBM bisa minimal, sehingga bisa menghemat biaya operasional kapal, selain juga emisi yang dihasilkan lebih rendah. Untuk itu perlu adanya modifikasi pada mesin diesel kapal nelayan yaitu dengan pemasangan konverter kit. Sasaran dalam kegiatan pengabdian ini adalah nelayan di Kalanganyar, Sidoarjo, Jawa Timur.
KİLİS’TE KAYBOLAN BİR ZANAAT: KEÇECİLİK VE SON USTASI
Authors: TARÇIN Gülsüm
Published: March 2023

Keçe, ortaya çıkış tarihi tam olarak bilinmemekle birlikte çeşitli arkeolojik kazılardan da elde edilen bulgulara göre, insanlık tarihinde geçmişten günümüze birçok kullanım alanı olan bir tekstil ürünüdür. Geçmişte geleneksel yöntemlerle elde edilen keçe, bazı bölgelerde bu özelliğini korumakla birlikte, değişen hayat şartlarından dolayı teknolojik araçlar kullanılarak fabrikalarda üretilmektedir. Keçe, Kilis’te de geleneksel bir zanaat olarak yerini almış; ancak zaman içinde yaşam koşullarının ve ihtiyaçlarının değişmesi sonucunda kaybolan zanaatlar arasına girmiştir. Keçeden genellikle hayvanların sırtına koymak ve boynuna takmak için çeşitli malzemeler üretilerek hayvanlardan yararlanılmış, köy odalarına oda keçesi yapılmış, çobanlar için giysi yapılmıştır. Bu makalede Kilis’te keçecilik zanaatının son ustası olan Hüseyin Gültekin ile yaptığımız görüşmeden elde edilen verilere göre; keçe üretiminin teknik ve malzeme özellikleri, kullanım alanları, Kilis’te keçecilik zanaatının geçmişi ve bugünü hakkında bilgiler verilerek; Kilis’te kaybolan zanaatlar arasına giren keçecilik zanaatının ve son ustasının tanıtılması amaçlanmıştır. Konuyla ilgili literatür taraması, saha araştırması yöntemi ve görüşme tekniği uygulanmıştır.
Evaluation of Texts Produced by Artificial Intelligence in Terms of Folklore
Authors: BİLGE SAVCI Esra
Published: March 2023

Experience accumulation of mankind gained from life has preserved its existence by being transferred to the next generations for centuries. The geographies, climates, environmental conditions, technologies, economies and values of the communities in the processes they live in have formed their culture. All of the practices that preserve their relation with the past of the society in which they were created in the process of transferring the experience and accumulation from ancient times to new generations with the bond of tradition and shaped without losing their dynamism according to the needs of the time are within the scope of folklore researchers. Human communities have created and transferred their cultures in various cultural environments, especially in the oral culture environment. In the center of all these creation and transmission processes, people themselves have taken place. Mankind, which has produced various technologies throughout history, has developed electronic or digital technology as well as writing. The technology development has also played an active role in the creation and transmission of culture by human beings. Artificial intelligence technology developed by humanity is one of the most important technological developments of recent times and has started to show itself in almost every fields of life. Artificial intelligence has also been used in creating narrative texts. This brought up the problem of how the narratives created by artificial intelligence should be perceived or evaluated in what context. In this study, in the context of this problem, the situation of the texts within the scope of the principles of the folklore nature of the texts presented by the artificial intelligence, which was designed through algorithms, influenced by the technological developments, and the co-creation texts of the community, is discussed. Evaluations have been made on the differences of the texts from folklore texts. It has been seen that the produced texts have limitations in terms of context, depth and emotion transfer.
First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer
Authors: Haughey Magnus J. , Bassolas Aleix , Sousa Sandro , Baker Ann-Marie , Graham Trevor A. , Nicosia Vincenzo , Huang Weini
Published: March 2023

The signature of early cancer dynamics on the spatial arrangement of tumour cells is poorly understood, and yet could encode information about how sub-clones grew within the expanding tumour. Novel methods of quantifying spatial tumour data at the cellular scale are required to link evolutionary dynamics to the resulting spatial architecture of the tumour. Here, we propose a framework using first passage times of random walks to quantify the complex spatial patterns of tumour cell population mixing. First, using a simple model of cell mixing we demonstrate how first passage time statistics can distinguish between different pattern structures. We then apply our method to simulated patterns of mutated and non-mutated tumour cell population mixing, generated using an agent-based model of expanding tumours, to explore how first passage times reflect mutant cell replicative advantage, time of emergence and strength of cell pushing. Finally, we explore applications to experimentally measured human colorectal cancer, and estimate parameters of early sub-clonal dynamics using our spatial computational model. We infer a wide range of sub-clonal dynamics, with mutant cell division rates varying between 1 and 4 times the rate of non-mutated cells across our sample set. Some mutated sub-clones emerged after as few as 100 non-mutant cell divisions, and others only after 50,000 divisions. The majority were consistent with boundary driven growth or short-range cell pushing. By analysing multiple sub-sampled regions in a small number of samples, we explore how the distribution of inferred dynamics could inform about the initial mutational event. Our results demonstrate the efficacy of first passage time analysis as a new methodology in spatial analysis of solid tumour tissue, and suggest that patterns of sub-clonal mixing can provide insights into early cancer dynamics.
Development of a machine learning model for early prediction of plasma leakage in suspected dengue patients
Authors: Zargari Marandi Ramtin , Leung Preston , Sigera Chathurani , Murray Daniel Dawson , Weeratunga Praveen , Fernando Deepika , Rodrigo Chaturaka , Rajapakse Senaka , MacPherson Cameron Ross
Published: March 2023

Background

At least a third of dengue patients develop plasma leakage with increased risk of life-threatening complications. Predicting plasma leakage using laboratory parameters obtained in early infection as means of triaging patients for hospital admission is important for resource-limited settings.

Methods

A Sri Lankan cohort including 4,768 instances of clinical data from N = 877 patients (60.3% patients with confirmed dengue infection) recorded in the first 96 hours of fever was considered. After excluding incomplete instances, the dataset was randomly split into a development and a test set with 374 (70%) and 172 (30%) patients, respectively. From the development set, five most informative features were selected using the minimum description length (MDL) algorithm. Random forest and light gradient boosting machine (LightGBM) were used to develop a classification model using the development set based on nested cross validation. An ensemble of the learners via average stacking was used as the final model to predict plasma leakage.

Results

Lymphocyte count, haemoglobin, haematocrit, age, and aspartate aminotransferase were the most informative features to predict plasma leakage. The final model achieved the area under the receiver operating characteristics curve, AUC = 0.80 with positive predictive value, PPV = 76.9%, negative predictive value, NPV = 72.5%, specificity = 87.9%, and sensitivity = 54.8% on the test set.

Conclusion

The early predictors of plasma leakage identified in this study are similar to those identified in several prior studies that used non-machine learning based methods. However, our observations strengthen the evidence base for these predictors by showing their relevance even when individual data points, missing data and non-linear associations were considered. Testing the model on different populations using these low-cost observations would identify further strengths and limitations of the presented model.
Fetoscopic endoluminal tracheal occlusion with Smart-TO balloon: Study protocol to evaluate effectiveness and safety of non-invasive removal
Authors: Sananès Nicolas , Basurto David , Cordier Anne-Gaël , Elie Caroline , Russo Francesca Maria , Benachi Alexandra , Deprest Jan
Published: March 2023

Introduction

One of the drawbacks of fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia is the need for a second invasive intervention to reestablish airway patency. The “Smart-TO” (Strasbourg University-BSMTI, France) is a new balloon for FETO, which spontaneously deflates when positioned near a strong magnetic field, e.g., generated by a magnetic resonance image (MRI) scanner. Translational experiments have demonstrated its efficacy and safety. We will now use the Smart-TO balloon for the first time in humans. Our main objective is to evaluate the effectiveness of prenatal deflation of the balloon by the magnetic field generated by an MRI scanner.

Material and methods

These studies were first in human (patients) trials conducted in the fetal medicine units of Antoine–Béclère Hospital, France, and UZ Leuven, Belgium. Conceived in parallel, protocols were amended by the local Ethics Committees, resulting in some minor differences. These trials were single-arm interventional feasibility studies. Twenty (France) and 25 (Belgium) participants will have FETO with the Smart-TO balloon. Balloon deflation will be scheduled at 34 weeks or earlier if clinically required. The primary endpoint is the successful deflation of the Smart-TO balloon after exposure to the magnetic field of an MRI. The secondary objective is to report on the safety of the balloon. The percentage of fetuses in whom the balloon is deflated after exposure will be calculated with its 95% confidence interval. Safety will be evaluated by reporting the nature, number, and percentage of serious unexpected or adverse reactions.

Conclusion

These first in human (patients) trials may provide the first evidence of the potential to reverse the occlusion by Smart-TO and free the airways non-invasively, as well a safety data.
Marine citizenship: The right to participate in the transformation of the human-ocean relationship for sustainability
Authors: Buchan Pamela M. , Evans Louisa S. , Pieraccini Margherita , Barr Stewart
Published: March 2023

Marine citizenship is a relatively new field of enquiry and research to date has focused on individual pro-environmental behaviour change as an expression of responsibility towards the ocean. The field is underpinned by knowledge-deficit and technocratic approaches to behaviour change such as awareness raising, ocean literacy, and environmental attitudes research. In this paper we develop an interdisciplinary and inclusive conceptualisation of marine citizenship. We use mixed methods to study the views and experiences of active marine citizens in the United Kingdom to broaden understandings of marine citizens’ characterisation of marine citizenship, and their perceptions of its importance in policy- and decision-making. Our study shows that marine citizenship entails more than individual pro-environmental behaviours, and includes public-facing and socially collective political actions. We contextualise the role of knowledge, finding more complexity than normative knowledge-deficit approaches permit. We illustrate the importance of a rights-based framing of marine citizenship which incorporates political and civic rights to participate in the transformation of the human-ocean relationship for sustainability. Recognising this more inclusive approach to marine citizenship, we propose an expanded definition to support further exploration of the multiple dimensions and complexities of marine citizenship and to enhance its benefits for marine policy and management.
Chaperone-mediated autophagy promotes breast cancer angiogenesis via regulation of aerobic glycolysis
Authors: Chen Rui , Li Peng , Fu Yan , Wu Zongyao , Xu Lijun , Wang Junhua , Chen Sha , Yang Mingzhen , Peng Bingjie , Yang Yao , Zhang Hongwei , Han Qi , Li Shuhui
Published: March 2023

Evidence shows that chaperone-mediated autophagy (CMA) is involved in cancer cell pathogenesis and progression. However, the potential role of CMA in breast cancer angiogenesis remains unknown. We first manipulated CMA activity by knockdown and overexpressing of lysosome-associated membrane protein type 2A (LAMP2A) in MDA-MB-231, MDA-MB-436, T47D and MCF7 cells. We found that the tube formation, migration and proliferation abilities of human umbilical vein endothelial cells (HUVECs) were inhibited after cocultured with tumor-conditioned medium from breast cancer cells of LAMP2A knockdown. While the above changes were promoted after cocultured with tumor-conditioned medium from breast cancer cells of LAMP2A overexpression. Moreover, we found that CMA could promote VEGFA expression in breast cancer cells and in xenograft model through upregulating lactate production. Finally, we found that lactate regulation in breast cancer cells is hexokinase 2 (HK2) dependent, and knockdown of HK2 can significantly reduce the ability of CMA-mediated tube formation capacity of HUVECs. Collectively, these results indicate that CMA could promote breast cancer angiogenesis via regulation of HK2-dependent aerobic glycolysis, which may serve as an attractive target for breast cancer therapies.
Safe and effective thrombolysis in free flap salvage: Intra-arterial urokinase infusion
Authors: Kim Jun Hyeok , Yoon Sungyeon , Kwon Heeyeon , Oh Deuk Young , Jun Young-Joon , Moon Suk-Ho
Published: March 2023

Despite the high success rate in reconstruction using free tissue transfer, flap failure is often caused by microvascular thrombosis. In a small percentage of cases with complete flap loss, a salvage procedure is performed. In the present study, the effectiveness of intra-arterial urokinase infusion through the free flap tissue was investigated to develop a protocol to prevent thrombotic failure. The retrospective study evaluated the medical records of patients who underwent salvage procedure with intra-arterial urokinase infusion after reconstruction with free flap transfer between January 2013 and July 2019. Thrombolysis with urokinase infusion was administered as salvage treatment for patients who experienced flap compromise more than 24 hours after free flap surgery. Because of an external venous drainage through the resected vein, 100,000 IU of urokinase was infused into the arterial pedicle only into the flap circulation. A total of 16 patients was included in the present study. The mean time to re-exploration was 45.4 hours (range: 24–88 hours), and the mean quantity of infused urokinase was 69,688 IU (range: 30,000–100,000 IU). 5 cases presented with both arterial and venous thrombosis, while 10 cases had only venous thrombosis and 1 case had only arterial thrombosis; in a study of 16 patients undergoing flap surgery, 11 flaps were found to have survived completely, while 2 flaps experienced transient partial necrosis and 3 were lost despite salvage efforts. In other word, 81.3% (13 of 16) of flaps survived. Systemic complications, including gastrointestinal bleeding, hematemesis, and hemorrhagic stroke, were not observed. The free flap can be effectively and safely salvaged without systemic hemorrhagic complications using high-dose intra-arterial urokinase infusion within a short period of time without systemic circulation, even in delayed salvage cases. Urokinase infusion results in successful salvage and low rate of fat necrosis.
Phosphorylation of GntR reduces Streptococcus suis oxidative stress resistance and virulence by inhibiting NADH oxidase transcription
Authors: Niu Kai , Meng Yu , Liu Mingxing , Ma Zhe , Lin Huixing , Zhou Hong , Fan Hongjie
Published: March 2023

GntR transcription factor of Streptococcus suis serotype 2 (SS2) is a potential substrate protein of STK, but the regulation mechanisms of GntR phosphorylation are still unclear. This study confirmed that STK phosphorylated GntR in vivo, and in vitro phosphorylation experiments showed that STK phosphorylated GntR at Ser-41. The phosphomimetic strain (GntR-S41E) had significantly reduced lethality in mice and reduced bacterial load in the blood, lung, liver, spleen, and brain of infected mice compared to wild-type (WT) SS2. Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) experiments demonstrated that the promoter of nox was bound by GntR. The phosphomimetic protein GntR-S41E cannot bind to the promoter of nox, and the nox transcription levels were significantly reduced in the GntR-S41E mutant compared to WT SS2. The virulence in mice and the ability to resist oxidative stress of the GntR-S41E strain were restored by complementing transcript levels of nox. NOX is an NADH oxidase that catalyzes the oxidation of NADH to NAD+ with the reduction of oxygen to water. We found that NADH is likely accumulated under oxidative stress in the GntR-S41E strain, and higher NADH levels resulted in increased amplified ROS killing. In total, we report GntR phosphorylation could inhibit the transcription of nox, which impaired the ability of SS2 to resist oxidative stress and virulence.
Arquitectura, vanguardia y distopía: la inversión de los proyectos utópicos en la ficción especulativa y su rol en la pantalla
Authors: Meléndez Galán Enrique
Published: March 2023

El presente escrito tiene como objetivo aproximarse a la inversión sufrida por la arquitectura de vanguardia a ojos del cine y al papel que juegan dichas construcciones en los decorados, como localizaciones o como entorno digital en cintas de ficción especulativa. Desde Metropolis (Lang, 1927) hasta The Man in the High Castle (Spotnitz, 2015-2019), pasando por Fahrenheit 451 (Truffaut, 1966) o Alphaville (Godard, 1965), entre otras, el planteamiento de narrativas de anticipación bebe, arquitectónicamente, de unas realidades que se reflejan en estas cintas para que, a modo de espejo en el que se invierte la realidad, se muestre el peor de los mundos posibles a través de edificios proyectados, originalmente, como auténticas utopías. A través de una revisión bibliográfica y fílmica, veremos cómo se da paso de la utopía a la distopía y cómo podemos aproximarnos a esas construcciones desde otras perspectivas que permitan no solo analizar esa inversión de proyectos a través del tiempo, sino fomentar una puesta en valor de la arquitectura también como patrimonio fílmico.
Las utopías en las Relaciones Internacionales: Brasil, el Sur Global y Occidente
Authors: Crescentino Diego
Published: March 2023

A partir de una reflexión profunda en torno al papel que cumplen las utopías en los proyectos políticos que intervienen en las relaciones internacionales, este artículo tiene como objetivo analizar el cambio de rumbo de la política exterior de Brasil en el periodo 2003-2022. Ello implica observar la transformación sufrida por la acción internacional del país, de una posición de defensor del Sur Global, a otra de adalid de Occidente. Para este fin, esta propuesta se valdrá de la triangulación de información ofrecida por fuentes primarias —documentos y discursos oficiales de la presidencia y del ministerio de Relaciones Exteriores— y secundarias —análisis de publicaciones académicas—. Con ello en mente, se hará una introducción teórica a través de la cual se abordará genealógicamente el pensamiento utópico en la disciplina de las Relaciones Internacionales y el campo del Análisis de la Política Exterior. Posteriormente, serán definidas dos estrategias discursivas, que aluden a proyectos antagónicos de inserción internacional asentados en imaginarios utópicos opuestos, y que han guiado a la cosmovisión brasileña de la realidad internacional en las dos primeras décadas del siglo xxi: el Brasil del Sur Global y el Brasil de Occidente. A modo de cierre, se trazarán algunas reflexiones finales, destacando el rol que cumplen ambas representaciones en la proyección doméstica e internacional de Brasil de cara al periodo de gobierno que inició en 2023. Se entiende que ambas cosmovisiones tienen su origen en la tradición de pensamiento internacional de Brasil, pero incorporan, además, variables que remiten a proyectos utópicos transnacionales.
DEVELOPMENT OF BUSINESS STRUCTURES DURING THE COVID-19 PANDEMIC
Authors: Vakkasova A. R.
Published: March 2023

The relevance of the topic is dictated by the fact that currently the ongoing transformational processes in the modern economy have almost completely covered all business structures and require scientists to develop fundamentally new methods and methodologies for the formation of an effective organizational and economic mechanism for their development. The positive impact of entrepreneurship on the economic system of the state is beyond doubt. In addition to budget revenues and job creation, as a factor of socio-economic development, entrepreneurship is also the most mobile instrument of economic relations in the new market realities, helping to systematically transform the economy of the state. This article examines the current state and development of entrepreneurial structures in Russia and the problems faced by entrepreneurs in carrying out economic activities. The result of the research is the solution of the tasks of substantiating theoretical and methodological provisions and developing practical recommendations for the formation and development of business structures in modern conditions of increased instability and crisis caused by the COVID-19 pandemic.
Jawz Endomyocardial Biopsy Forceps from Argon Medical:
A Review of Safety and Efficacy Based on Literature Review and Bench Model Comparison With the Cordis Bioptome
Authors: Stibbs Peter
Published: March 2023

Endomyocardial biopsy (EMB) is a critical tool for the diagnosis and management of cardiac diseases, as well as to gauge allograft rejection post heart transplant.¹ Traditional EMB techniques can be difficult, time-consuming without adequate image guidance, and may carry a risk of complications or inconclusive diagnosis attributed to crush artifact or inadequate specimen yield.²

The Jawz Endomyocardial Biopsy Forceps from Argon Medical(
Athens,TX. USA)is a device designed to simplify the EMB procedure by optimizing excisional removal of myocardium. This paper will review the safety and efficacy of the Jawz biopsy forceps, including data from cited studies and bench top model comparison to the Cordis bioptome
(Cordis Medical, Miami Lakes,FL.USA)