bluuebunny/crossref_metadata_2025 huggingface dataset:
Dysfunction of Decidual Macrophages Is Apotential Risk Factor in the Occurrence of Preeclampsia
Authors: Rong Miaomiao , Yan Xingyu , Zhang Hongya , Zhou Chan , Zhang Cong
Published: January 2021

Background: Preeclampsia is a multi-factorial and multi-genetic disorder that affects more than eight million mother and baby pairs each year. Currently, most of the attention to the pathogenesis of preeclampsia has been focused on placenta, but recent progresses suggest that excellent decidualization lays foundation for placentation and growth. Moreover, preeclampsia is associated with an imbalance in immunoregulatory mechanisms, however, how the immune regulatory system in the decidua affects preeclampsia is still unclear.Methods: In our study, we used conventional expression profiling to compare the expression and function of differential genes contained in decidua parietalis of the preeclampsia and normal human. After intersecting the genes differentially expressed between preeclampsia and the control and the genes contained in the ligand receptor network, we further explored their involvement in cell-to-cell interactions using CellPhoneDB analysis. We finally used single-cell sequencing to detect interactions between decidual cells.Results: After intersecting the genes of differentially expressed between preeclampsia and the control gotten by conventional sequencing and the genes contained in the ligand receptor network, we found eight differentially expressed genes in a ligand-receptor relationship, and the eight genes have a characteristic: most of them participate in the interaction between decidual macrophages and other decidual immune cells. The results of single-cell sequencing of decidual cells further demonstrated that decidual macrophages affect the functions of other immune cells through export. As a result, abnormal gene expression affects the export function of decidual macrophages, which in turn affects the interaction of decidual macrophages with other immune cells.Conclusions: The abnormal export function of decidual macrophages affects the function of immune cells interacting with them, thereby destroying the original immune regulation mechanism, and ultimately leading to the occurrence of preeclampsia.
Impact of COVID-19 on the Central Nervous System: Are Spontaneous Intracranial Haemorrhage and Aseptic Meningitis Extrapulmonary Manifestations of COVID-19?
Authors: HASSAN MOHAMED AWAD MOHAMED
Published: January 2021

Background:The coronavirus pandemic that started in December 2019 is mainly related to respiratory symptoms. Clinical presentations have been reported, but so far, no definitive therapy has been established. Intracranial haemorrhage has been observed in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, but the clinical, imaging, and pathophysiological features of intracranial bleeding during coronavirus disease 2019 (COVID-19) infection remain poorly characterized. The occurrence of spontaneous intracranial haemorrhage complicated with aseptic meningitis secondary to COVID-19 is extremely rare.Case presentation:A 19-month-old fever, and shortness of breath was admitted to our intensive care unit on an emergency basis. Two weeks later, the patient developed a generalized convulsion with deterioration of consciousness. A computed tomography scan of the brain revealed a bifrontal intracerebral haemorrhage compressing the anterior horns of both lateral ventricles of the brain with a massive intraventricular haemorrhage causing hydrocephalus. Emergency ventriculostomy was performed, and a nasal swab for SARSCoV-2 was positive. Cerebrospinal fluid analysis and culture were negative for microorganisms, and analysis revealed features of aseptic meningitis.Conclusions:The possible occurrence of spontaneous intracranial haemorrhage and aseptic meningitis should be kept in mind by physicians, especially when treating critically ill young children with COVID-19. Early recognition Conclusions: The possible occurrence of spontaneous intracranial haemorrhage and aseptic meningitis should be kept in mind by physicians, especially when treating critically ill young children with COVID- 19. Early recognition of central nervous system involvement may be key to providing a better prognosis.
Human Placental Mesenchymal Stem Cells Ameliorate Liver Fibrosis in Mice by Upregulation of Caveolin1 in Hepatic Stellate Cells
Authors: Yao Yunqi , Xia Zhemin , Cheng Fuyi , Jang Qingyuan , He Jiao , Pan Cheng , Zhang Lin , Ye Yixin , Wang Yuan , Chen Shuang , Su Dongsheng , Su Xiaolan , Cheng Lin , Shi Gang , Dai Lei , Deng Hongxin
Published: January 2021

Background: Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix. Severe LF causes cirrhosis and even liver failure, a major cause of morbidity and mortality worldwide. Transplantation of human placental mesenchymal stem cells (hPMSCs) has been considered as an alternative therapy, replacing liver transplantation in clinical trials, to treat LF. However, the underlying mechanisms and the appropriate time window for hPMSC transplantation are not well understood. Methods: We established mouse models of CCL4-injured LF, and administered hPMSCs once a week for 2 weeks. The therapeutic effect of hPMSCs on LF was investigated, according to histopathological and blood biochemical analyses. What’s more, the culture supernatant of hPMSCs were isolated, and the effect of the culture supernatant on the inhibition of activated HSCs was also assessed. RNA sequencing (RNA-seq) analysis, Real-time PCR array, and western blotting were performed to explore possible signaling pathways involved in treatment of IF with hPMSCs. Results: hPMSC treatment can alleviate experimental hepatic fibrosis, restore liver function, and inhibit inflammation. Furthermore, the therapeutic effect of hPMSCs against mild to moderate LF was significantly greater than against severe disease. Mechanistic dissection studies suggested ameliorating LF using hPMSCs occur partly by restoring Caveolin-1 (Cav1) in activated hepatic stellate cells (HSCs). Upregulation of Cav1 can inhibit the TGF-β/Smad signaling pathway, mainly by reducing Smad2 phosphorylation, resulting in the inhibition of activated HSCs, whereas this effect could be abated if Cav1 was silenced in advance by siRNAs. Conclusions: Our findings suggest that hPMSCs could provide multifaceted therapeutic benefits for the treatment of LF, and the TGF-β/Cav1 pathway might act as a therapeutic target for hPMSCs in the treatment of LF.
Heat Shock Preconditioning Mesenchymal Stem Cells Attenuate Acute Lung Injury via Reducing NLRP3 Inflammasome Activation in Macrophages
Authors: Lv Haijin , Yuan Xiaofeng , Zhang Jiebin , Lu Tongyu , Yao Jia , Zheng Jun , Cai Jianye , Xiao Jiaqi , Chen Haitian , Xie Shujuan , Ruan Ying , An Yuling , Sui Xin , Yi Huimin
Published: January 2021

Objectives: Acute lung injury (ALI) remains one of the common causes of morbidity and mortality worldwide, so far, without any effective therapeutic approach. Previous researches have revealed that topical administration of umbilical cord-derived mesenchymal stem cells (UC-MSCs) can attenuate pathological changes in experimental acute lung injury. Heat shock (HS) pretreatment has been identified as a method to enhance survival and function of cells. The present study aimed to assess whether HS-pretreated mesenchymal stem cells (MSCs) could strengthen the immunomodulation and recovery from ALI. Materials and Methods: HS pretreatment was defined 42℃ for 1h, the changes of biological characteristics and the secreted functions were detected. In the mouse model of ALI, we intranasally dripped the pretreated UC-MSCs in vivo, confirmed their therapeutic effects and detected the phenotypes of macrophages in bronchoalveolar lavage fluid (BALF). To elucidate their mechanisms, we co-cultured the pretreated UC-MSCs with macrophages in vitro, and the expression levels of inflammasome-related proteins in macrophages were assessed. Finally, Apoptozole was used for further determine the role of HSP70 in HS-pretreated UC-MSCs-based therapy. Results: The data showed that UC-MSCs did not represented significant changes in viability and biological characterizations after received HS pretreatment. Administration of HS-pretreated UC-MSCs into the ALI model, improved pathological changes and lung damage-related indexes, reduced of the levels of pro-inflammatory cytokines and modulated the balance of M1/M2. Mechanistically, both in vivo and in vitro studies demonstrated that HS pretreatment enhanced the protein level of HSP70 in UC-MSCs and subsequently upregulated the synthesis and secretion of PGE2, which negatively modulated the NLRP3 inflammasome activation of alveolar macrophages. And these effects was partially reversed by Apoptozole. Conclusion: HS pretreatment can strengthen the beneficial effects of UC-MSCs on inhibiting NLRP3 inflammasome activation of macrophages in ALI. The mechanism may be contributed to the upregulated expression of HSP70 to further induce PGE2 synthesis and secretion.
Analysis of 23 Pediatric Patients with SARS-CoV-2 Infection in Anhui Province, China
Authors: Fang Lulu , Wang Wang , Huo Shaohu , Liu Jun , Han Ming feng , Wei Ming , Gao Hui , Ding Sheng-Gang
Published: January 2021

Background: The global spread of coronavirus disease 2019 (COVID-19) continues to threaten all human health worldwide. Although the symptoms, signs, responses, and outcomes associated with the disease varies for individuals, few studies have reported on pediatric patients with COVID-19.Methods: This study retrospectively reviewed the medical records from three tertiary hospitals in Anhui province, China, of 23 children with COVID-19. Here, epidemiologic characteristics, clinical features, laboratory test results, and treatment strategies for these pediatric patients are reported and analyzed.Results: In total, 23 children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were analyzed. All patients were given a nucleic acid detection test for SARS-CoV-2, and positive results confirmed the diagnosis of COVID-19. Ten patients (43.5%) were female, and 19 patients (82.6%) had defined exposure history and familial clustering. The youngest patient was 16 months of age, the oldest, 17 years. The clinical symptoms of all included pediatric patients with SARS-CoV-2 infection were mild, with cough (12, 52.2%) and fever (10, 43.5%) being the most frequent, making their symptoms indistinguishable from common respiratory infections. There was no difference in clinical manifestation between males and females (P > 0.05). Eight patients (34.8%) showed changes on chest computed tomography imaging. The median level of each laboratory test parameter was within the normal reference range. Treatments primarily included antiviral therapies, traditional Chinese medicine therapies, and symptomatic supportive treatment.Conclusions: The symptoms of all 23 pediatric patients with SARS-CoV-2 infection included in this study were mild. Because the primary presenting symptoms were indistinguishable from common respiratory infections and because most patients had an exposure history and familial clustering, we recommend supporting the diagnosis of mild or atypical COVID-19 in children with detailed epidemiologic information and chest computed tomography imaging as well as with nucleic acid detection tests. Obtaining a correct diagnosis in the early stage of the disease will contribute to controlling the spread of SARS-CoV-2 infection and to providing more immediate relevant treatment for infected children.
Genome Mining for Antimicrobial Compounds in Wild Marine Animals-associated Enterococci
Authors: Prichula Janira , Primon-Barros Muriel , Luz Romeu , Castro Ícaro , Paim Thiago , Tavares Maurício , Ligabue-Braun Rodrigo , d’Azevedo Pedro , Frazzon Jeverson , Frazzon Ana , Seixas Adriana , Gilmore Michael
Published: January 2021

New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are of special interest because of their low toxicity and compatibility with host health. Here we identified and characterized biosynthetic gene clusters encoding antimicrobial compounds in host-associated enterococcal recovered from fecal samples of wild marine animals remote from human-affected ecosystems. Putative biosynthetic gene clusters in the genomes of 22 Enterococcus strains of marine origin were predicted using antiSMASH5 and Bagel4 bioinformatic software. At least one gene cluster encoding a putative bioactive compound precursor was identified in each genome. Collectively, 73 putative antimicrobial compounds were identified, including 61 bacteriocins (83.56 %), 10 terpenes (13.70 %), and two (2.74 %) related to putative nonribosomal peptides (NRPs). Two of the species studied, Enterococcus avium and Enterococcus mundtti, are rare causes of human disease and were found to lack any known pathogenic determinants but yet possessed bacteriocin biosynthetic genes, suggesting possible additional utility as probiotics. Wild marine animal-associated enterococci from human-remote ecosystems provide a potentially rich source for new antimicrobial compounds of therapeutic and industrial value, and potential probiotic application.
Ontology Generation for Flight Safety Messages in Air Traffic Management(ATM)
Authors: Aghdam1 mahdi Yousefzadeh , Kamel Seyed Reza , Chabok Seyed Javad Mahdavi , khairabadi maryam
Published: January 2021

The analysis of various data is a challenging issue in the field of air traffic flow management (ATFM). Managing a large volume of data and their correct interpretation plays a key role in the prevention of air accidents, human errors, and flight interactions. In general, pilots and flight navigators deal with massive information, including flight safety messages, meteorological messages, aviation NOTAMs, aviation company information messages, and airplane system alerts. Air collisions are possible due to the high volume and variety of such information considering the human errors in their interpretation and application. Therefore, attempts should be made to develop systematic information and establish logical communication between large data volumes in order to increase the reliability factor in flights. Recently, the semantic web has been recognized as a novel foundation of knowledge management that relies on ontology (concept modeling language) and effective techniques for the modeling of integrated information systems and eliminating barriers to the interpretation and exchange of data. The present study aimed to propose an efficient infrastructure for ATMs by defining the concepts, rules, and relationships between the concepts related to the scope of flight information. To this end, we designed and implemented the ontology of flight safety messages, which included an important part of flight operation information. In this research, the IPS-based aviation networks and methontology methodology were exploited for the engineering of the ontology of flight messages. In addition, the implementation process was carried out using the Protégé software. The analysis of the system was performed using the actual data of Mashhad Airport, Iran. The obtained data were based on the inbound and outbound flights of the airport, which were collected using the radar system and FDS and normalized. Finally, the implementation of the ontology of flight messages was demonstrated after a case study of several flight examples. The developed ontology could be incorporated into the foundation of an ATN aviation network as an application.
Exogenous biological renal support improves kidney function in rhabdomyolysis-induced acute kidney injury in mice
Authors: Liu Chao , Chi Kun , Geng Xiaodong , Hong Quan , Mao Zhi , Huang Qi , liu Dong , Wang Yiqin , Zhang Yin , Zhou Feihu , Cai Guangyan , Chen Xiangmei , Sun Xuefeng
Published: January 2021

BackgroundRhabdomyolysis (RM) is a clinical syndrome characterised by the breakdown of skeletal muscle fibres and release of their contents into the circulation. Myoglobin-induced acute kidney injury (AKI) is one of the most severe complications of RM. Based on our previous study, exogenous biological renal support alleviates renal ischaemia-reperfusion injury (IRI) in elderly mice. This study aimed to determine whether exogenous biological renal support promoted renal recovery from RM-induced AKI and to preliminarily explore the mechanisms involved.MethodsA parabiosis animal model was established to investigate effects of exogenous biological renal support on RM-induced AKI. Male wild-type C57BL/6 mice and C57BL/6-TgN (ACTb-EGFP) transgenic mice were used to determine whether shared circulation was established among parabiotic pairs 3 weeks after parabiosis surgery. Mice were divided into three groups: the control group (sterile saline injected); RM group (glycerol (8 mL/kg) injected); and parabiosis + RM group (three weeks after the parabiosis model was established, the recipient mouse was injected with glycerol). Blood samples and kidney tissue were collected for further processing 48 hours after RM induction. Bioinformatics analysis was conducted with Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, functional enrichment analysis and clustering analysis.ResultsAt 48 hours after the procedure, all mice survived. Exogenous biological renal support attenuated the histological and functional deterioration in RM-induced AKI in mice. Bioinformatics analysis identified key pathways and proteins involved in this process. We further demonstrated that exogenous biological renal support ameliorated kidney injury through multiple pathways, including suppressing the complement system; attenuating oxidative stress, inflammation, and apoptosis; and increasing proliferation.ConclusionsExogenous biological renal support provided by parabiosis can improve renal function in RM-induced AKI by suppressing the complement system; decreasing oxidative stress, inflammation, and apoptosis; and promoting tubular cell proliferation. Our study provides new ideas for effectively preventing and treating RM-induced AKI and provides basic research evidence for the use of bioartificial kidneys to treat RM-induced AKI.
The use of mobile phones for the prevention and control of arboviral diseases: a scoping review
Authors: Carrillo Maria Angelica , Kroeger Axel , Sanchez Rocio Cardenas , Monsalve Sonia Diaz , Ranzinger Silvia Runge
Published: January 2021

Background: The rapid expansion of dengue, Zika and chikungunya with large scale outbreaks are an increasing public health concern in many countries. Additionally, the recent coronavirus pandemic urged the need to get connected for fast information transfer and exchange. As response, health programmes have -among other interventions- incorporated digital tools such as mobile phones for supporting the control and prevention of infectious diseases. However, little is known about the benefits of mobile phone technology in terms of input, process and outcome dimensions. The purpose of this scoping review is to analyse the evidence of the use of mobile phones as an intervention tool regarding the performance, acceptance, usability, feasibility, cost and effectiveness in dengue, Zika and chikungunya control programmes. Methods: We conducted a scoping review of studies and reports by systematically searching: i) electronic databases (PubMed, PLOS ONE, PLOS Neglected Tropical Disease, LILACS, WHOLIS, ScienceDirect and Google scholar), ii) grey literature, using Google web and iii) documents in the list of references of the selected papers. Selected studies were categorized using a pre-determined data extraction form. Finally, a narrative summary of the evidence related to general characteristics of available mobile health tools and outcomes was produced. Results: The systematic literature search identified 1289 records, 32 of which met the inclusion criteria and 4 records from the reference lists. A total of 36 studies were included coming from twenty different countries. Five mobile phone services were identified in this review: mobile applications (n = 18), short message services (n=7), camera phone (n = 6), mobile phone tracking data (n = 4), and simple mobile communication (n = 1). Mobile phones were used for surveillance, prevention, diagnosis, and communication demonstrating good performance, acceptance and usability by users, as well as feasibility of mobile phone under real life conditions and effectiveness in terms of contributing to a reduction of vectors/ disease and improving users-oriented behaviour changes. It can be concluded that there are benefits for using mobile phones in the fight against arboviral diseases as well as other epidemic diseases. Further studies particularly on acceptance, cost and effectiveness at scale are recommended.
Maize-IAS: A Maize Image Analysis Software using Deep Learning for High-throughput Plant Phenotyping
Authors: Zhou Shuo , Chai Xiujuan , Yang Zixuan , Wang Hongwu , Yang Chenxue , Sun Tan
Published: January 2021

Background : Maize (Zea mays L.) is one of the most important food sources in the world and has been one of the main targets of plant genetics and phenotypic research for centuries. Observation and analysis of various morphological phenotypic traits during maize growth are essential for genetic and breeding study. The generally huge number of samples produce an enormous amount of high-resolution image data. While high throughput plant phenotyping platforms are increasingly used in maize breeding trials, there is a reasonable need for software tools that can automatically identify visual phenotypic features of maize plants and implement batch processing on image datasets. Results : On the boundary between computer vision and plant science, we utilize advanced deep learning methods based on convolutional neural networks to empower the workflow of maize phenotyping analysis. This paper presents Maize-PAS ( Maize Phenotyping Analysis Software), an integrated application supporting one-click analysis of maize phenotype, embedding multiple functions: I. Projection, II. Color Analysis, III. Internode length, IV. Height, V. Stem Diameter and VI. Leaves Counting. Taking the RGB image of maize as input, the software provides a user-friendly graphical interaction interface and rapid calculation of multiple important phenotypic characteristics, including leaf sheath points detection and leaves segmentation. In function Leaves Counting, the mean and standard deviation of difference between prediction and ground truth are 1.60 and 1.625. Conclusion : The Maize-PAS is easy-to-use and demands neither professional knowledge of computer vision nor deep learning. All functions for batch processing are incorporated, enabling automated and labor-reduced tasks of recording, measurement and quantitative analysis of maize growth traits on a large dataset. We prove the efficiency and potential capability of our techniques and software to image-based plant research, which also demonstrates the feasibility and capability of AI technology implemented in agriculture and plant science. Keywords : Maize phenotyping; Instance segmentation; Computer vision; Deep learning; Convolutional neural network
Morphological, behavioral and molecular studies on CRISPR/Cas9-mediated knockout of the NOMO1 gene in zebrafish
Authors: Li Fei , Li Tingting , Lin Jia , Jian Jing , Zhang Qi , Zhang Yinglan , Liu Xiuyun , Ji Yongxia , Wang Xu , Li Qiang
Published: January 2021

Background: Multiple clinical genome-wide analysis identified that chromosome 16p13.11 is a hotspot associated with neuropsychiatric disorders such as autism, schizophrenia and epilepsy. Nodal modulator 1 (NOMO1), located on human chromosome 16p13.11, was considered as a candidate gene with neuropsychiatric disorders. However, it is unknown whether the nomo1 deficiency causes neurological abnormalities, and the molecular mechanisms and pathogenesis of the NOMO1 gene remain unclear. To study the effects of nomo1 deficiency on brain development and neuropsychiatric system, a nomo1 knockout zebrafish model was established.Methods: We developed a viable vertebrate model of nomo1 loss-of-function using CRISPR/Cas9 technology and characterized nomo1 mutant zebrafish. Phenotypic and functional studies of developing nomo1 mutant zebrafish, including morphological measurements, behavioral assays, and functional mechanistic analyses, were performed.Results: Morphological differences in the phenotype of nomo1-/- zebrafish gradually became less noticeable during development, however, the enlarged interstitial spaces in midbrain and hindbrain were detected in nomo1 mutant zebrafish. Meanwhile, the nomo1 deficiency caused the change of expression levels in neurotransmitters of γ-aminobutyrate, glutamate and serotonin. Interestingly, the nomo1 loss-of-function zebrafish model exhibited social defects and repetitive behaviors in juvenile, which represented autism-like behaviors. The transcriptome analysis showed different gene expression patterns in mutant zebrafish at the genetic level. Further results revealed that the neuroactive drug PTZ recovered the decreased locomotor phenotype in larval mutant zebrafish.Conclusions: In this study, we established a nomo1 vertebrate animal model using CRISPR/Cas9 gene editing approach. The loss-of-function of nomo1 displayed autism-like behaviors and altered levels of the γ-aminobutyrate, glutamate and serotonin in zebrafish, which provide evidence that nomo1 as a candidate gene for autism. The versatility of zebrafish model is contributed to studying NOMO1-related disorders and conducting drug screening in future.Limitations: Further studies are needed to determine whether an intervention with a neuroactive drug in nomo1-/- zebrafish to alter the behavioral phenotype is applicable to the behavior of human patients.
Perbaikan Berkelanjutan Pada Sistem Penjadwalan Perkuliahan Dengan Penjadwalan Berbasis Aplikasi dan Website
Authors: Anggraini Wresni , Warman Febri Novia
Published: January 2021

Lecture scheduling systems that made manually need longer time and should be made time after time (trial and error) because there are many constrains should be considered like: number of classes, number of lecturers, number of courses and number of students. Delay in publishing class schedule could cause disruption in the lecture process. As an eﬀort to continuous improvement, designing lecture schedule system based on application or website which easy to use by user was very needed. This research aims to design lecture scheduling information systems based on website and android in Industrial Engineering Department, Islamic State University Sultan Syarif Kasim Riau. This research also measures system success rate by using User Acceptance Testing (UAT). The fnding reveals based on UAT analysis to the information system of lecture scheduling designed, as an average, the success rate was 85.1% from 100% success expected.
Perencanaan Sistem Informasi untuk Mendukung Analisis Pemasaran menggunakan Metode EAP pada PT. Cherokendo Benua Wisata
Authors: Musthofa Tegar Aryo Sulthon , Wang Gunawan
Published: January 2021

This case study conducted for information system planning by applying EAP methodology on PT. Cherokendo Benua Wisata. EAP is an approach to building a planned information system architecture. Case studies successfully identifed 12 business function and produces enterprise architecture. Architecture consists of data architecture, application architecture, and technology architecture. The Enterprise architecture can be use by company for guideline to develop information system.
Aplikasi Parkir Menggunakan Ionic Framework dan Firebase
Authors: Chandra Natalia , Sutan Kelvindo , Antonious Christian , Handoko Christian
Published: January 2021

Jakarta as the capital of the Republic of Indonesia as well as being the largest city in Indonesia. The high number of Jakarta residents as well as the increase in the number of vehicles has become a potential congestion in certain areas, such as shopping centers, because the high value of transactions in parking management services has resulted in long queues. There are several problems that often occur in the parking area, as for the problem is the number of vehicles that want to park exceeds the parking capacity, long queues at the door of payment on weekends, it is difcult to contact vehicle owners who vehicles have problem. One of them is through this research which aims to develop a Hybrid mobile-based online parking payment application. The application of the application is expected to be a solution for users in the parking transaction process through the virtual money system as a parking payment tool and provide applications that can notify vehicle owners who have problems. The methodology applied in this research is by analyzing prospective users and analyzing similar applications.
Somos Todos Artistas. Um exercício de reflexão a respeito da autonomia criativa e das formas de classificação relacionadas à criação
Authors: Martins Cynthia Carvalho , Valle Camila do
Published: January 2021

This article is about the construction of identities of artists working in the streets taking as reference the movemnt "Life is a party". This movement occurs since 2002 and put all together artists from the music, visual arts, dramatic art, literature of "cordel", "Tambor de Crioula", poetry and "Bumba meu bi" with performances every thursday in the center of the brazilian city São Luís do Maranhão. This approach includes reflections about expressions showed in this event as "art of the streets" or "art in the streets", as a singular mode of solidarity among the artists and a way to build social relations. In the case analysed here, the production of art implies a identity of artist that deny the institutional and market relations of meaning.
Revisitando o grotesco: O indefinível como transgressão na arte
Authors: Mello Júlia Almeida de
Published: January 2021

This article presents an analysis of the grotesque as a transgressive element of artistic canons, norms and dominant discourses, considering different periods in the art history(ies). From its manifestation as an aesthetic category in descriptions of Domus Aurea in fifteenth century to the disordered bodies that confront categorizations in contemporary art, the grotesque is constantly in motion and although it cannot be classified it is immediately identified as provocative. Approaches linking Visual Culture to gender issues and political identities are made by emphasizing works that incorporate the excess, the “abnormal”, the “uncanny”, the ambiguity and other grotesques’ manifestations to break boundaries. The results reveal that the grotesque can be seen as a political strategy in different contexts, including its dialogue with the current proposals of provocation of the dissent in contemporary art.
The implementation of zoning system in suburban schools in Tulungagung Regency, Indonesia
Authors: Ariani Ariek Tri
Published: January 2021

This research aims to find out the meaning or nature; process; and the causal relationship between the school zoning system in the suburbs of Tulungagung Regency. This thesis was made using a qualitative descriptive approach with a multiple case study approach; to then associate research findings with several practical and empirical theories. These research objects are SMPN 2 Campurdarat, SMPN 1 Tanggunggunung, and SMPN 1 Besuki Tulungagung. The qualitative analysis technique used was the Multiple Case Study, with the research instrument interviewing with school principals and PPDB operators. This research was prepared based on several studies of the problem that the periphery school is one of the parties who benefit in implementing this zoning system compared to urban schools in Tulungagung Regency in terms of the ceiling's fulfillment. The findings of the study show that determination of the amount of ceiling in PPDB with the zoning system in schools in rural areas is following the regulations regarding the tensile strength of PPDB in Tulungagung Regency as stipulated in the Decree of the Head of the Youngest and Sports Education Office in Tulungagung Regency number: 188/1035/104,010/2019 concerning Determination of Schedule and Capability of Acceptance of New, Kindergarten, Elementary and Middle School Students in 2019/2020 Academic Year. The preparation of high human resources has well supported the process. The series of PPDB activities with the zoning system in rural areas in Tulungagung Regency has been carried out well by PPDB committees in each school. Evaluation of the implementation of PPDB with the zoning system in the outskirts of Tulungagung Regency has fulfilled aspects of effectiveness, efficiency, adequacy, equity, and responsiveness and accuracy; and an evaluation system has been carried out based on the principle of policy impact; i.e., comparing conditions before and after the policy is carried out.
PREVENÇÃO DO BULLYING NA INFÂNCIA:
Authors: Popenga Geraim Monteiro Michelle , Lima-Berton Tatiane Delurdes de , Asinelli-Luz Araci
Published: January 2021

Pensando na trajetória que ainda deve ser construída para a proteção da infância, discute-se a criança e os fatores de prevenção do bullying escolar, uma vez que existe a necessidade de aprofundar os saberes relacionados à prevenção, violações, violências e convivência escolar e a ampliação da experiência enquanto educadores, na tentativa de organizar ações e estratégias preventivas para infância, salientando a participação da instituição escolar, de espaços não escolares e a participação comunitária, como fontes de contribuição e corresponsabilidade. Trata-se de um estudo bibliográfico e com alcance descritivo. Uma discussão teórica que envolve autores sobre a criança e a Sociologia da Infância, sobre o bullying escolar e a prevenção à violência. A importância de abordar essas áreas da educação ocorre em razão da construção de vínculos afetivos tanto no ambiente escolar quanto em outros espaços com atividades que visam fortalecimento de vínculos e a convivência, nos quais o professor/educador trabalha em conjunto com profissionais que atuam fora da escola, envolvendo nessa perspectiva a participação da família e da comunidade.
Índice de bloqueo para mejorar la protección diferencial de secuencia negativa de transformadores utilizando ATP/EMTP
Authors: Torres García Vicente , Guillen Daniel , Olivares Galván Juan Carlos
Published: January 2021

En este trabajo se presenta un nuevo índice de bloqueo para mejorar el rendimiento de la protección diferencial del transformador basado en la secuencia negativa. Para garantizar la confiabilidad de cualquier red eléctrica, los esquemas de protección son una tarea principal. Particularmente, los transformadores de potencia porque están sujetos a eventos transitorios tales como fallas entre espiras, corrientes de magnetización y sobreexcitación. En consecuencia, la protección del transformador debe funcionar correctamente bajo fenómenos transitorios. Para analizar fallas internas y eventos transitorios en transformadores, se implementa una protección diferencial de secuencia negativa mediante el uso del software ATP / EMTP. El esquema propuesto emplea un esquema de protección diferencial (87Q), que se basa principalmente en la diferencia angular entre secuencias negativas de corrientes primarias y secundarias utilizando un ángulo de operación de relé (ROA). Esta protección mejorada introduce un índice de bloqueo para evitar el mal funcionamiento durante la energización del transformador porque ha sido reportado que el ROA puede presentar un mal funcionamiento durante eventos transitorios. El nuevo índice introducido representa una distancia entre secuencias durante el período transitorio, lo que ayuda a discriminar las fallas internas de las corrientes de energización. En este sentido, los autores presentan una evaluación del índice de bloqueo introducido para evitar el mal funcionamiento, especialmente cuando esta protección está funcionando en condiciones desbalanceadas, o en condiciones transitorias, como la corriente de energización. Con base en los resultados, la propuesta presenta un buen desempeño y su efectividad se demuestra bajo diferentes escenarios de falla.
Maqāṣid al-Sharī’ah Critique of Nahdlatul Ulama’s Fiqh of Disability
Authors: Asep Mohamad
Published: January 2021

This article critically examines the implementation of the concept of maqāṣid in the construction of the Nahdlatul Ulama’s (NU) fiqh of disability. It purposes to intellectually confirm whether the mode of Islamic legal interpretation (ijtihād) of the construction has been influenced by the horizon of the thought of maqāṣidi (the higher objective of Islamic law) or has not. This confirmation is essential, since it seems that the fiqh of disability produced by Lembaga Bahtsul Masail NU/LBMNU (the Islamic legal body) is humanistic and egalitarian. However, are both inclinations the result of intellectual elaborations within the circle of NU Muslim jurists (‘ulama’) – those who have taken a position on the side of maqāṣid legal consideration? Engaging closely with this issue, this article claims that there is no study that specifically examining the maqāṣid al-sharī’ah in the NU’s fiqh of disability. This article arguably asserts that the NU’s fiqh of disability has been enlightened by the maqāṣidi perspective and it is highly likely consistent in considering the virtue of maṣlaḥah (the public good) as the ultimate goal of maqāṣid, especially for disabled people. This consistency can be identified from the NU’s fatwas (Islamic legal opinions).
La presencia alemana en la Ciudad de México: La firma comercial de Carlos Haghenbeck Cía. 1852-1858
Authors: Carapia Medina María Guadalupe
Published: January 2021

El objetivo del presente artículo tiene como finalidad analizar la presencia de un migrante procedente del estado prusiano, que vino a México en 1844, que logró establecerse como un acaudalado comerciante en la segunda mitad del siglo decimonónico, a través de redes de paisanaje y familiar que coadyuvaron en la consolidación de Carl Hypolite Haghenbeck Braunwald, en el mundo del negocio del comercio de ropa y mercería en la Ciudad de México.
El secretario del obispo: poesía, chistes y secreto episcopal en los escritos relativos al gobierno de la diócesis de Santiago de Chile en la segunda mitad del siglo XVIII
Authors: Urrejola Bernarda
Published: January 2021

En este trabajo me acerco a la figura invisible del secretario del obispo, un miembro muy importante de la llamada “familia” del prelado, lo que constituía su círculo más íntimo, de máxima confianza. El secretario, en efecto, era el encargado de guardar el “secreto” del obispo, es decir, los papeles más importantes para el gobierno de la diócesis, por lo que su función resultaba fundamental y estaba reglamentada por las disposiciones de Trento. El secretario actuaba muchas veces como notario o firmaba las cartas del obispo, pero nada se dice de la edición que hacía de textos eclesiásticos importantes que el obispo solo había escrito en borrador. Aquí se estudian al menos dos ejemplos en que la mano del secretario se desliza y puede ser identificada. Más allá de un nombre, es una “función” textual que añade, edita y adorna los dichos del obispo, para desaparecer tras él casi sin dejar huella.
Analog-digital hybrid impression technique in an elderly patient: a case report
Authors: Papazoglou Efstratios , Charalambous Constantinos
Published: January 2021

The hybrid impression technique consists of an initial alginate
impression that provides a pre-operative cast upon which a diagnostic
wax-up and a silicone index impression are made. This work is digitized;
thus, the altered final digital impression is limited to absolute
minimum time, effort and ensures comfort for the patient.
A six-year old boy with refractory mycoplasmal pneumonia combined with recurrent pneumothorax
Authors: Tao DongYing , Cheng ShengQuan , zeng minghua , niu huanhong
Published: January 2021

A six-year old boy presented with mycoplasmal pneumonia combined with
recurrent pneumothorax. The patient had been treated with azithromycin
and methylprednisolone for mycoplasmal pneumonia after admission,
however his condition deteriorated. We increased the dosage of
methylprednisolone and changed to erythromycin from azithromycin, his
condition improved progressively. He presented pneumothorax twice during
recovery phase. He was put on thoracic closed drainage and was cured.
Pneumothorax is rare complication of mycoplasmal pneumonia. Here we
reported the case to raise awareness of this condition.
Drug repurposing for COVID-19: the problem of excessive hypothesis testing
Authors: Maziarz Mariusz , Stencel Adrian
Published: January 2021

Rationale, aims, and objectives The current strategy of searching for an
effective drug to treat COVID-19 relies mainly on repurposing existing
therapies developed to target other diseases. There are currently more
than four thousand active studies assessing the efficacy of existing
drugs as therapies for COVID-19. The number of ongoing trials and the
urgent need for a treatment poses the risk that false-positive results
will be incorrectly interpreted as evidence for treatments’ efficacy and
a ground for drug approval. Our purpose is to assess the risk of
false-positive outcomes by analyzing the mechanistic evidence for the
efficacy of exemplary candidates for repurposing, estimate false
discovery rate, and discuss solutions to the problem of excessive
hypothesis testing. Methods We estimate the expected number of
false-positive results and probability of at least one false-positive
result under the assumption that all tested compounds have no effect on
the course of the disease. Later, we relax this assumption and analyze
the sensitivity of the expected number of true-positive results to
changes in the prior probability (π) that tested compounds are
effective. Finally, we calculate False Positive Report Probability and
expected numbers of false-positive and true-positive results for
different thresholds of statistical significance, power of studies, and
ratios of effective to non-effective compounds. We also review
mechanistic evidence for the efficacy of two exemplary repurposing
candidates (hydroxychloroquine and ACE2 inhibitors) and assess its
quality to choose the plausible values of the prior probability (π) that
tested compounds are effective against COVID-19. Results Our analysis
shows that, due to the excessive number of statistical tests in the
field of drug repurposing for COVID-19 and low prior probability (π) of
the efficacy of tested compounds, positive results are far more likely
to result from type-I error than reflect the effects of pharmaceutical
interventions.
Measuring the Impact of West Bengal Drinking Water Sector Improvement Project: A Baseline Study
Authors: Orbeta Aniceto C. , Pokhrel Neeta , Belliappa Saswati Ghosh , Dasgupta Saugata , Nandi Arati
Published: January 2021

Access to safe drinking water is a fundamental right of people. The West Bengal Drinking Water Sector Improvement Project is assisting the Government of West Bengal to provide safe, sustainable, and inclusive drinking water services to over 1.65 million people in the arsenic, fluoride, and salinity-affected areas of Bankura, North and South 24 Parganas, and Purba Medinipur districts. This publication sets the baseline of the project by providing the benchmark comparison of primary outcomes for the project and non-project households, before implementation, so that an impact evaluation can be carried out at project completion.
Extremity Trauma: Foreign Bodies and Vascular Injury
Authors: Meguerdichian David A. , Eicken John
Published: January 2021

It is important for physicians to be mindful of the possibility of a foreign body in the context of extremity trauma. Patients with foreign bodies may not suspect their presence, and a significant proportion of foreign bodies are missed by the initial treating physician. Trauma injuries to the peripheral vasculature can be divided into blunt and penetrating trauma, and can also be classified as occlusive or nonocclusive injuries. This review details the assessment and stabilization, diagnosis, treatment and disposition, and outcomes for patients with foreign body and vascular injuries. Figures show beside ultrasonography using a linear ray probe that demonstrates a foreign body wood splinter in soft tissue, the major arteries of the upper and lower extremities, and measurement of the ankle-brachial index in an injured limb with suspected vascular injury. Tables list supplies needed to perform bedside ultrasound-guided foreign body removal, steps to remove a foreign body under ultrasound guidance, hard and soft signs of arterial injuries, and high-risk orthopedic injuries and their commonly associated vascular injury.
This review contains 4 figures, 4 tables, and 51 references.
Lymphomas
Authors: Dunleavy Kieron , Wilson Wyndham H
Published: January 2021

Lymphoma is the fifth most common type of cancer in the United States, with 74,490 new cases estimated in 2009. Approximately 15% of patients with lymphoma have Hodgkin lymphoma; the remainder have one of the non-Hodgkin lymphomas. The incidence of non-Hodgkin lymphoma has increased steadily over recent decades. This chapter reviews the epidemiology, classification, clinical features, pathology, diagnostic evaluation, staging and prognosis, and treatment of Hodgkin and non-Hodgkin lymphoma. Other topics discussed include the acute and chronic effects of therapy for Hodgkin disease, as well as the subtypes of non-Hodgkin lymphomas, including indolent B cell lymphoma, follicular lymphoma, small lymphocytic lymphoma, mantle cell lymphoma, marginal-zone lymphoma, diffuse large B cell lymphoma (DLBCL), primary central nervous system lymphoma (PCNSL), Burkitt lymphoma, and HIV-related non-Hodgkin lymphoma. Figures illustrate the cellular appearance of Hodgkin lymphoma subtypes and DLBCL, diagnosis of DLBCL subtypes by gene expression, computed tomography and plain chest film in primary mediastinal cell lymphoma, MRI of the brain in PCNSL, and gene expression and gene expression predictors of survival among patients with DLBCL treated with rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine [Oncovin], and prednisone (R-CHOP). Tables describe the Ann Arbor classification and the Cotswold modification for staging of lymphoma; the International Prognostic Score for advanced Hodgkin lymphoma; the World Health Organization classification of hematopoietic neoplasms; chromosomal translocations in non-Hodgkin lymphoma; the Eastern Cooperative Oncology Group performance scale; the International Prognostic Index for aggressive non-Hodgkin lymphoma; and the Follicular Lymphoma International Prognostic Index. This chapter has 185 references.
This review contains 9 tables, 7 figures and 185 references