bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the potential implications of following a vegan diet on bone health
Authors: Clark A. , Kruger M.C. , Mazahery H. , Conlon C. , Beck K.L. , Mumme K. , Batty R. , von Hurst P.R.
Published: May 2024

Cow’s milk is the primary source of calcium in the NZ diet(1). The absence of dietary planning in a vegan diet can result in the individual unknowingly obtaining low intakes of calcium. Prolonged low calcium intakes can result in negative implications on bone mineral density by increasing the risk of osteoporosis later in life. The measurement of bone health parameters in NZ vegan adults have not been investigated. Therefore, we measured bone mineral density, markers of calcium homeostasis and assessed intake of essential nutrients for optimal bone health in vegans. This cross-sectional study included adults (>18yrs), who followed a vegan diet for 2 years minimum. Demographic and lifestyle information was obtained from questionnaires including previous history of bone fractures and background of familial osteoporosis. A 4-day food record was completed for analysis of calcium, zinc, protein, magnesium, phosphorus and vitamin C intake and compared to the Estimated Average Requirement (EAR)(2). Weight, height and BMI were obtained, bone mineral density was measured at the hip and spine via dual x-ray absorptiometry (DXA) and reported as Z and T scores. Plasma calcium concentrations were corrected for albumin. All values are presented as mean and standard deviation. The study included 212 participants, aged 39 ± 12.38 years, 71% female. T scores at the lumbar spine and femoral neck were −0.63 ± 1.22 (Z score: −0.29 ± 1.12) and −0.66 ± 1.00 (Z score: −0.24 ± 0.89), respectively. Nine participants had a Z-score of <-2.0 at the lumbar spine, and three at the femoral neck. Corrected calcium concentrations were 2.21 ± 0.33 mmol/L. Calcium intake was 917 ± 347.23 (range 195 to 2,429 mg/day) in all participants, which exceeded the EAR of 840 mg/day for adults aged 19-50 years. Men had higher intakes of calcium than women, 1,051 ± 363.7 mg/day (range 382 to 2,267 mg/day) vs. 867 ± 328.04 mg/day (range 194 to 2,428 mg/day), P-value <0.001. The main source of calcium in the vegan diet was tofu. The intake of protein (77 ± 27.80) g/day, magnesium (569 ± 181.05) mg/day, and vitamin C (145 ± 96.94) mg/day met the EAR, excluding vitamin and mineral supplements. However, the intake of phosphorus (1,472 ± 459.98) mg/day and zinc (10.6 ± 4.01) mg/day were below the EAR. The findings of this study suggest that bone health of vegans are not negatively affected by the exclusion of dairy in the diet, provided that appropriate dietary planning is included to avoid nutrient deficiencies associated with poor bone health. Despite mean intake of calcium exceeding the EAR, very low intakes demonstrated significant variations between participants.
Folic acid and iodine supplement use from preconception through to six weeks postpartum in New Zealand women
Authors: Hunter B. , Mazahery H. , Jin Y. , Gammon C.
Published: May 2024

Folic acid (FA) and iodine supplements are recommended by the Ministry of Health (MOH) for pregnant and/or lactating women in New Zealand (NZ)(1). Evidence suggests that many NZ women are not just taking FA and iodine in the form of a single-nutrient supplement (SNS) but are taking FA and iodine as part of a multivitamin supplement (MVS) which may or may not contain the recommended doses, and some are using a combination of both(2). No NZ study has examined the daily dose taken from both SNS and MVS for both FA and iodine across all time periods (2, 3). The aim of this study was to investigate what nutritional supplements containing FA and iodine were taken by postpartum NZ women, preconception, during the three trimesters of pregnancy and post-partum, and examine how well the women’s supplement use aligned with the NZ MOH recommendations. This cross-sectional observational study utilised data gathered on FA and iodine supplement use from an anonymous survey between February and August 2022. Descriptive statistics including frequency and percentages were reported. Folic acid and iodine weekly intakes from SNS and MVS were calculated by multiplying the amount of nutrient in each supplement, with the number of times per day taken, and the average number of days taken per week reported. A total of 584 women were included in the analysis. In addition to the SNS for FA (0.8mg and 5mg) and iodine (150 ug), women took 28 different MVS. Fifty-eight percent (preconception; 30% from SNS, 18% from MVS, and 10% from both) and 96% (1st trimester pregnancy; 61% from SNS, 17% from MVS, and 19% from both) of women took FA containing supplements. More than 75% of women reported taking iodine containing supplements during pregnancy (1st and 2nd trimesters: 93%, 3rd trimester: 89%) and postpartum (76%).Approximately 60% took SNS, 18% took only MVS and 14% took both. Based on the MOH recommendations, only 30% (preconception) and 62% (1st trimester) achieved sufficiency of FA supplementation at 0.8mg/day; 35% (preconception) and 69% (1st trimester) achieved sufficiency of FA at 5mg/day; around 50% women achieved sufficiency of iodine supplementation at 150 µg/day during pregnancy while only 37% during postpartum. The balance either took none, an insufficient dose or a dose that exceeded the recommended dose and many took them during non-recommended periods (FA after the 1st trimester; iodine preconception). Most women reported taking FA and/or iodine containing supplements at some point before, during and after their pregnancy. However, it is concerning that a large number of women do not seem to be adhering to the MOH recommendations for FA and iodine supplementation.
Dietary phytochemicals as regulators of gut inflammation in the context of type 2 diabetes
Authors: Visvanathan R. , Williamson G. , Houghton M.J.
Published: May 2024

Numerous disorders, including type 2 diabetes and even COVID-19, are linked to poor gut health and inflammation(1,2). In addition to impacting food digestion and absorption, gut inflammation worsens diabetes outcomes by causing gut microbial dysbiosis, disrupting tight junctions (allowing microbial metabolites to freely enter into circulation), and altering glucose absorption(3). ACE2 is a crucial regulator of gut health and has received much attention during the COVID-19 pandemic due to its role as a major viral entry protease. Studies have shown that the ACE2/Ang-(1-7)/Mas axis is important in managing inflammation and maintaining normal glucose metabolism(3). Dietary phytochemicals are plant bioactive compounds, with promising anti-inflammatory and anti-diabetic properties, and may affect these processes. In this work, we aimed to look at the link between inflammation, ACE2 and the glucose transporters, SGLT1 and GLUT2, and how phytochemicals could be used to normalise the changes brought about by inflammation in Caco-2/TC7 human intestinal epithelium cells. We first examined how gut inflammation, ACE2 and glucose transporters are related and proceeded to look at the effect of some chosen phytochemicals on regulating glucose transport via modulation of the ACE2/Ang(1-7)/Mas axis. This included genistein (an isoflavone from soyabeans), sulforaphane (an isothiocyanate found in Brassica, especially broccoli), apigenin (a flavone found in vegetables and herbs), and artemisinin (a sesquiterpene lactone used as a drug). The impact of phytochemicals on the SARS-CoV-2 viral entry receptors, ACE2 and TMPRSS2, was also examined as a secondary outcome. To induce inflammation, the Caco2/TC7 cells were co-stimulated with IL-1β (25 ng/mL) and TNF-α (50 ng/mL) for varying durations (24 h, 48 h, 72 h, 168 h) and changes in target gene expression (ACE2, SGLT1, GLUT2, TMPRSS2) were assessed by droplet digital PCR. IL-6 and IL-8 were assessed as markers of inflammation in the cell culture media by multiplex ELISA. Inflammation increased ACE2, TMPRSS2 and SGLT1 mRNA. ACE2 increased with cytokine exposure duration, coupled with an obvious decrease in IL-8, SGLT1 and TMPRSS2. Pearson correlation analysis revealed that the increase in ACE2 was strongly associated with decreases in SGLT1 (r = −0.99, p<0.01) and IL-8 (r = −0.959, p<0.05), implying ACE2 to play a crucial role in gut inflammation and postprandial glycaemia. After establishing the gut cell inflammation model, we compared the effect of the phytochemicals on our target genes in cells cultured in normal and pro-inflammatory environments. None of the tested phytochemicals were effective in reducing IL-8 secretion, while phytochemicals showed varying effects on the target genes. Genistein normalised the effects of inflammation on the target genes with less effect from the other tested phytochemicals. However, further research is required to assess the importance of genistein in vivo in the context of gut inflammation and type 2 diabetes.
Not Just a Commercial Voyage: A Cultural-Historical Perspective of the East Indiaman Compton's Voyage to Bombay (1723–26)
Authors: Grossi Erica
Published: May 2024

This essay aims to give an account of the untold and unexpected events faced by the crew of the Compton, one of the East India Company's vessels that set out on a routine trade voyage from Deptford to Bombay in April 1723. Under the command of Captain William Mawson, scrupulous compiler of the logbook, the ship proceeded along the known routes indicated by the East India Company (EIC) charts, and through the passages recommended by the navigation manuals. Finding consonance with recent research suggestions on “alternative histories” of the EIC, this article brings to light the narrative potentialities of the logbook, which is therefore considered not only a technical device, but also a tool for reconstructing the actual experience of navigation. This is the approach of the historical geodatabase of European global navigation Global Sea Routes (GSR), which bases its research method on ship's logs and other primary sources produced by the practitioners themselves. In order to provide a richer account of the known history of the EIC's shipping in the early modern age, this essay will analyse Mawson's logbook, highlighting its peculiarities as a container for a wealth of information useful for creating a narrative construction.
Orderings of extremes among dependent extended Weibull random variables
Authors: Samanta Ramkrishna Jyoti , Das Sangita , Balakrishnan N.
Published: May 2024

In this work, we consider two sets of dependent variables $\{X_{1},\ldots,X_{n}\}$ and $\{Y_{1},\ldots,Y_{n}\}$, where $X_{i}\sim EW(\alpha_{i},\lambda_{i},k_{i})$ and $Y_{i}\sim EW(\beta_{i},\mu_{i},l_{i})$, for $i=1,\ldots, n$, which are coupled by Archimedean copulas having different generators. We then establish different inequalities between two extremes, namely, $X_{1:n}$ and $Y_{1:n}$ and $X_{n:n}$ and $Y_{n:n}$, in terms of the usual stochastic, star, Lorenz, hazard rate, reversed hazard rate and dispersive orders. Several examples and counterexamples are presented for illustrating all the results established here. Some of the results here extend the existing results of [5] (Barmalzan, G., Ayat, S.M., Balakrishnan, N., & Roozegar, R. (2020). Stochastic comparisons of series and parallel systems with dependent heterogeneous extended exponential components under Archimedean copula. Journal of Computational and Applied Mathematics380: Article No. 112965).
Development of derivational morphological knowledge in monolingual and bilingual children: Effects of modality and lexicality
Authors: Michaly Tamar , Prior Anat
Published: May 2024

This study mapped the trajectory of developing derivational morphological knowledge in Hebrew monolingual and Russian–Hebrew bilingual children. We investigated 2nd and 4th graders, using a two-by-two structure along the dimensions of modality (comprehension, production) and type of word (real-word, pseudo-word). Performance in the morphological analogies comprehension tasks improved with grade, and monolingual and bilingual children performed equally well. A different pattern was evident in production tasks. In real-word production, monolingual children were more accurate than bilingual children, but this group difference narrowed with age. In pseudo-word production, monolingual children used more morphological elements than bilingual children, and there was also a tendency towards group differences narrowing with age. Detailed error analyses across all tasks revealed that monolingual children recruited more morphological elements than bilingual children. We present implications for assessment of morphological knowledge, and suggest that morphological intervention is a promising avenue for promoting bilingual children’s success.
Fine-scale phylogenetic diversity gradients support the Antarctic geothermal refugia hypothesis
Authors: Pearman William S. , Adams Clare I.M. , Monteiro Maria , Quesada Antonio , Fraser Ceridwen I.
Published: May 2024

The possible role of geothermal areas, such as volcanoes, in fostering biodiversity in Antarctica has received considerable recent attention. Under a geothermal refugia hypothesis, diverse life could be supported near or at geothermal sites, and we should see decreasing diversity and/or patterns of nestedness moving away from ‘hotspots’. Although there is evidence that geothermal areas have played a role in the persistence of some terrestrial species through glacial periods in Antarctica, the spatial scales at which such refugia operate is not clear. We sampled sediment from a range of locations across volcanic Deception Island in the Maritime Antarctic and used eDNA metabarcoding approaches (targeting a region of the 28S marker) to assess patterns of diversity in relation to thermal gradients. We found that although colder sites harboured significantly greater taxonomic richness than warmer sites, phylogenetic diversity was lower at colder sites (i.e. taxa at colder sites tend to be more evolutionary close to each other). We infer that increased selective processes in low-temperature environments have reduced phylogenetic diversity, supporting a hypothesis of geothermal locations acting as refugia for diverse taxa, even on fine spatial scales, in cold-climate regions such as Antarctica.
A Pilot Randomized Controlled Trial of Augmented Reality Just-in-Time Guidance for the Performance of Rugged Field Procedures
Authors: O’Connor Laurel , Zamani Sepahrad , Ding Xinyi , McGeorge Nicolette , Latiff Susan , Liu Cindy , Acevedo Herman Jorge , LoConte Matthew , Milsten Andrew , Weiner Michael , Boardman Timothy , Reznek Martin , Hall Michael , Broach John P.
Published: May 2024

Introduction:

Medical resuscitations in rugged prehospital settings require emergency personnel to perform high-risk procedures in low-resource conditions. Just-in-Time Guidance (JITG) utilizing augmented reality (AR) guidance may be a solution. There is little literature on the utility of AR-mediated JITG tools for facilitating the performance of emergent field care.

Study Objective:

The objective of this study was to investigate the feasibility and efficacy of a novel AR-mediated JITG tool for emergency field procedures.

Methods:

Emergency medical technician-basic (EMT-B) and paramedic cohorts were randomized to either video training (control) or JITG-AR guidance (intervention) groups for performing bag-valve-mask (BVM) ventilation, intraosseous (IO) line placement, and needle-decompression (Needle-d) in a medium-fidelity simulation environment. For the interventional condition, subjects used an AR technology platform to perform the tasks. The primary outcome was participant task performance; the secondary outcomes were participant-reported acceptability. Participant task score, task time, and acceptability ratings were reported descriptively and compared between the control and intervention groups using chi-square analysis for binary variables and unpaired t-testing for continuous variables.

Results:

Sixty participants were enrolled (mean age 34.8 years; 72% male). In the EMT-B cohort, there was no difference in average task performance score between the control and JITG groups for the BVM and IO tasks; however, the control group had higher performance scores for the Needle-d task (mean score difference 22%; P = .01). In the paramedic cohort, there was no difference in performance scores between the control and JITG group for the BVM and Needle-d tasks, but the control group had higher task scores for the IO task (mean score difference 23%; P = .01). For all task and participant types, the control group performed tasks more quickly than in the JITG group. There was no difference in participant usability or usefulness ratings between the JITG or control conditions for any of the tasks, although paramedics reported they were less likely to use the JITG equipment again (mean difference 1.96 rating points; P = .02).

Conclusions:

This study demonstrated preliminary evidence that AR-mediated guidance for emergency medical procedures is feasible and acceptable. These observations, coupled with AR’s promise for real-time interaction and on-going technological advancements, suggest the potential for this modality in training and practice that justifies future investigation.
Legal Counterrevolution: Property and Judicial Power in the Weimar Republic
Authors: Maier Clara
Published: May 2024

This article offers a new account of the rise of judicial power in modern Germany. Strong judicial control of the government is often associated with the constitutional ethos that emerged in postwar West Germany as a reaction to Nazi rule. This article locates the origins of German judicialization in the political struggles of the Weimar era. It shows how the assumption of a power to judicial review by Germany's highest court, the Reichsgericht, was the product of the successful cooperation of the judiciary with conservative political parties on the issue of property rights in the young republic. These were at the centre of two controversies examined in the article: the expropriation of princes of former ruling houses and the consequences of the hyperinflation of 1923. In both cases the Reichsgericht used an understanding of property as an inalienable right to radically reinterpret Germany's first democratic constitution, which had in fact granted the legislature extensive power to modify property relations. This suited the judiciary's own objective of assuming stronger controls over legislative action and bolstered the political position of conservative forces in Weimar politics. What emerged was a supra-positive constitutionalism that sought to supersede the written constitution. These political realities were an essential context for theoretical debates on the extent and limits of judicial power between theorists such as Carl Schmitt, Hans Kelsen, Hermann Heller, Franz Neumann, and Ernst Fraenkel. An examination of the complex interaction of parliamentary, judicial, and popular politics concerning the issue of property reveals that German judicial empowerment amounted to an attempt to rewrite the Weimar Constitution and limit the scope of Germany's democratic revolution.
Mesoscale Auroral Curls in Antarctica
Authors: Li Xing‐Yu , Zong Qiu‐Gang , Hu Ze‐Jun , Wang Yong‐Fu , Liu Jian‐Jun , Zhou Xu‐Zhi , Yue Chao , Wang Shan , Xie Zi‐Kang , Zhao Xing‐Xin , Liu Zhi‐Yang , Yin Ze‐Fan , Zhao Hua‐Yu , Sun Yi‐Xin
Published: May 2024

The morphology and motion of auroras have been widely studied due to their indications on magnetospheric processes. Here, we report a new kind of “auroral curls,” which have wavelengths in the mesoscale (∼100 km) and propagate azimuthally. Utilizing data from the Chinese Antarctic Zhongshan Station (the all‐sky imager and the high‐frequency radar), the Active Magnetosphere and Planetary Electrodynamics Response Experiment and the Defense Meteorological Satellite Program, we analyze an event occurred on 23 April 2019. We find these curls are fine structures in the poleward boundary of multiple arcs. Corresponding field‐aligned currents manifest as a series of longitudinally arranged pairs, while ionospheric flow velocities nearby oscillate with periods in the Pc 5 band. Observational evidence suggests these curls are connected with ultra‐low frequency (ULF) waves, which opens the possibility of using auroras to globally image ULF waves.
Self Consistent Modeling of Relativistic Runaway Electron Beams Giving Rise to Terrestrial Gamma‐Rays Flashes
Authors: Gourbin P. , Celestin S.
Published: May 2024

Terrestrial Gamma Ray Flashes (TGFs) are short bursts of gamma rays occurring during thunderstorms. They are believed to be produced by Relativistic Runaway Electron Avalanches (RREAs). In this paper, we present a new numerical model based on the Particle‐In‐Cell (PIC) method to simulate the interactions between the electromagnetic fields and the electron avalanche self‐consistently. The code uses a cylindrical Yee lattice to numerically solve the electromagnetic fields, a Monte Carlo approach to simulate collisions with air molecules, and a plasma fluid model to calculate the effects of low‐energy electrons and ions. The model is first tested through the reproduction of dispersion relations in a hot plasma. RREAs propagating under a homogeneous background electric field are then simulated. Owing to the self‐consistent nature of this description, we report here new physical properties such as saturation processes in the electron density and in the number of high‐energy electrons, detailed dynamical screening of the electric field in the ion trail of the avalanche, and the associated electric currents. We find that the saturation of RREAs is obtained when the numbers of high‐energy electrons and photons is consistent with those believed to be representative of TGF sources.
Microphysical Characteristics of Precipitation Over Eastern China and Its Coastal Regions
Authors: Sun Yue , Zhao Chuanfeng , Fan Hao
Published: May 2024

Many studies have investigated the macro‐ and micro‐physical properties of precipitation, but few classified precipitation into warm‐ and cold‐topped, which affects precipitation phase and precipitation type significantly. Furthermore, the impact of moisture and dynamics on microphysical characteristics of precipitation has been less studied. Using precipitation data from the GPM 2A DPR between May and September from 2015 to 2023, this study conducts a systematic study on microphysical characteristics of precipitation over eastern China and its coastal areas. This study divides precipitation cases into 20 categories, including warm‐/cold‐topped (CTP/WTP) convective/stratiform light/moderate/heavy/extreme/the most extreme precipitation. The findings reveal distinct differences along with similarities in various precipitation categories between eastern China and its coastal regions. The convection ratio for CTP increases with higher precipitation intensity, while WTP is dominated by convective precipitation. The more CTP, the higher the solid water content. The heavier precipitation, the higher liquid water content contributes. The mass‐weighted diameter (Dm) for CTP shows three variations from high to low with little or slight decrease with altitude at upper‐layer, followed by a rapid increase at middle‐layer and finally decreasing slightly at low‐layer. The CTP Dm grows rapidly with temperature from −18.58 (−13.93)°C for convective (stratiform) precipitation and their maximum growth rate are almost located in melting layer. Dm (raindrop density) is larger (lower) over land than ocean and larger (lower) for CTP than WTP. Dm shows positive relation to vertical velocity and specific humidity, especially sensitive to the middle‐ and upper‐layers meteorological conditions.
Urban XCO2 Gradients From a Dense Network of Solar Absorption Spectrometers and OCO‐3 Over Mexico City
Authors: Che Ke , Lauvaux Thomas , Taquet Noemie , Stremme Wolfgang , Xu Yang , Alberti Carlos , Lopez Morgan , García‐Reynoso Agustín , Ciais Philippe , Liu Yi , Ramonet Michel , Grutter Michel
Published: May 2024

Satellite measurements of urban CO2 plumes offer a global approach to track CO2 emissions for large cities. To examine and to quantify the feasibility of space‐based monitoring, an intensive measurement campaign (MERCI‐CO2) using seven solar‐tracking Fourier transform infrared (FTIR) spectrometers has been conducted over the Mexico City Metropolitan Area (MCMA) to monitor urban emissions and to evaluate Snapshot Area Map (SAM) observations from the NASA's Orbiting Carbon Observatory‐3 (OCO‐3) mission. Once adjusted for their respective averaging kernels, we diagnosed a positive difference between OCO‐3 and FTIR column measurements (1.06 ppm). Thanks to this unprecedented amount of column observations over a large city, we demonstrate that XCO2 gradients within OCO‐3 SAMs align with the inter‐calibrated FTIR measurements (mean bias of 0.3 ppm), confirming the potential to track CO2 emissions from space over large metropolitan areas. XCO2 urban‐rural differences across the FTIR network, show a strong correlation with observed gradients, with Pearson's correlation coefficients (R) around 0.92. The correlation is significantly lower when considering intra‐urban gradients, where R drop to around 0.24. Simulated XCO2 enhancements (ΔXCO2) based on X‐STILT for both FTIR and OCO‐3 show relatively high correlations (R is around 0.6) using high‐resolution footprints and two gridded inventories. Spatial correlations with OCO‐3 improve when aggregating satellite retrievals at coarser resolutions (10 km). Our study demonstrates the capabilities of detecting urban gradients by FTIR network and OCO‐3 SAM observations over MCMA, a promising result to evaluate the evolution of MCMA's emissions over the coming decade.
Surface Geological Evolution in the Chang'e 5 Landing Area (Em4 Unit) Revealed by a New Age‐Retrieving Method From Regression Learning
Authors: Chen Yuchao , Huang Qian , Zhao Jiannan , Yin Haolin
Published: May 2024

The chronology function and production function have been widely used to derive the model ages of lunar mare regions from crater size‐frequency distributions. Challenges remain in homogenous counting area selection, crater saturation and crater rim identification. Geological unit‐based ages are also difficult to study the continuous surface evolution among adjacent areas. Using regression‐learning models, we have tried a new method on the Em4 unit of the Chang'e 5 landing area to explore a quantitative relationship between ages and surface morphometric expressions using texture features. Four features (Contrast, Energy, Entropy and Homogeneity), together with a stepwise linear model (SL) and a linear support‐vector‐machine model (LS), are well selected to produce a pixel‐level continuous age map of the Em4 unit. Mean age values of 1.75 ± 0.26 Ga and 1.69 ± 0.22 Ga obtained respectively from the two models are consistent with the ages of Chang'e 5 samples returned from this area. Both texture features and age maps are separated along the NW‐SE sinuous rilles (Rima Sharp and Rima Mairan). Comprehensively considering the geology, geomorphology, and newly retrieved ages of the study region, we have proposed a three‐stage evolution process for the Em4 unit. Our new age‐retrieving method is useful for obtaining a pixel‐level high‐resolution age map in the study region and has the potential to be widely used in other lunar mare areas.
The Impacts of Changing Winter Warm Spells on Snow Ablation Over Western North America
Authors: Scaff Lucia , Krogh Sebastian A. , Musselman Keith , Harpold Adrian , Li Yanping , Lillo‐Saavedra Mario , Oyarzún Ricardo , Rasmussen Roy
Published: May 2024

An increase in winter air temperature can amplify snowmelt and sublimation in mountain regions with implications to water resources and ecological systems. Winter Warm Spells (WWS) are defined as a winter period (December to February, DJF) of at least 3 consecutive days with daily maximum temperature anomaly above the 90th percentile (using a moving‐average of 15 days between 2001 and 2013). We calculate WWS for every 4‐km grid cell within an atmospheric model over western North America to characterize WWS and analyze snow ablation and their changes in a warmer climate. We find that days with ablation during WWS represent a small fraction of winter days (0.6 days), however, 49% of total winter ablation (33.4 mm/DJF) occurs during WWS. Greater extreme ablation rates (99th percentile) occur 18% more frequently during WWS than during non‐WWS days. Ablation rates during WWS in humid regions are larger (9 mm d−1) than in dry regions (7 mm d−1) in a warmer climate, which can be explained by differences in the energy balance and the snowpack's cold content. We find that warmer (0.8°C), longer (1.8 days) and more frequent (3.7 more events) WWS increase total winter ablation (on average 109% or 18 mm/DJF) in a warmer climate. Winter melt during WWS in warm and humid places is expected to increase about 3 times more than in the cold and dry region. This study provides a comprehensive description of WWS and their impact on snowpack dynamics, which is relevant to reservoir operations and water security.
Generation of High‐Resolution Water Surface Slopes From Multi‐Mission Satellite Altimetry
Authors: Schwatke C. , Halicki M. , Scherer D.
Published: May 2024

For nearly three decades, satellite radar altimetry has provided measurements of the water surface elevation (WSE) of rivers. These observations can be used to calculate the water surface slope (WSS), which is an essential parameter for estimating flow velocity and river discharge. In this study, we calculate a non time‐varying high‐resolution WSS of 11 Polish rivers based on multi‐mission altimetry observations from 11 satellites in the period from 1994 to 2023. The proposed approach is based on a weighted least squares adjustment with an additional Laplace condition and an a priori gradient condition. The processing is divided into river sections not interrupted by dams and reservoirs. After proper determination of the WSE for each river kilometer (bin), the WSS between adjacent bins is calculated. To assess the accuracy of the estimated WSS, it is compared with slopes between gauge stations, which are referenced to a common vertical datum. Such gauge stations are available for 8 studied rivers. The root mean squared error (RMSE) ranges from 4 mm/km to 77 mm/km, with an average of 27 mm/km. However, the mean RMSE decreases to 11 mm/km when the 2 mountain rivers are excluded. The WSS accuracies are also compared with slope data sets based on digital elevation models, ICESat‐2 altimetry, and lidar. For 6 rivers the estimated WSS shows the highest accuracy. The improvement was particularly significant for mountain rivers. The proposed approach allows an accurate, non time‐varying high‐resolution WSS even for small and medium‐sized rivers and can be applied to almost any river worldwide.
Observations of Relativistic Electron Precipitation Due To Combined Scattering of Whistler‐Mode and EMIC Waves
Authors: Bashir M. Fraz , Artemyev Anton , Zhang Xiao‐Jia , Angelopoulos Vassilis , Tsai Ethan , Wilkins Colin
Published: May 2024

The two most important wave modes responsible for energetic electron scattering to the Earth's ionosphere are electromagnetic ion cyclotron (EMIC) waves and whistler‐mode waves. These wave modes operate in different energy ranges: whistler‐mode waves are mostly effective in scattering sub‐relativistic electrons, whereas EMIC waves predominately scatter relativistic electrons. In this study, we report the direct observations of energetic electron (from 50 keV to 2.5 MeV) scattering driven by the combined effect of whistler‐mode and EMIC waves using ELFIN measurements. We analyze five events showing EMIC‐driven relativistic electron precipitation accompanied by bursts of whistler‐driven precipitation over a wide energy range. These events reveal an enhancement of relativistic electron precipitation by EMIC waves during intervals of whistler‐mode precipitation compared to intervals of EMIC‐only precipitation. We discuss a possible mechanism responsible for such precipitation. We suggest that below the minimum resonance energy (Emin) of EMIC waves, the whistler‐mode wave may both scatter electrons into the loss‐cone and accelerate them to higher energy (1–3 MeV). Electrons accelerated above Emin resonate with EMIC waves that, in turn, quickly scatter those electrons into the loss‐cone. This enhances relativistic electron precipitation beyond what EMIC waves alone could achieve. We present theoretical support for this mechanism, along with observational evidence from the ELFIN mission. We discuss methodologies for further observational investigations of this combined whistler‐mode and EMIC precipitation.
Interannual Variability of Isopycnal Ocean Heat Content in the Subtropical Northeast Pacific
Authors: Guo Yongqing , Wei Meng
Published: May 2024

The subsurface thermal anomaly originating from the mid‐latitude Pacific significantly influences climate variability in the tropical Pacific. Traditionally, the spiciness anomaly, defined on an isopycnal surface, is used to estimate this thermal anomaly. However, the thermal anomaly is confined to an isopycnal layer with a certain thickness, not spread on a specific surface. Its impact on the tropical Pacific depends on the amount of heat reaching the equator. Therefore, the thickness‐weighted isopycnal ocean heat content (IPOHC), defined as the ocean heat content in an isopycnal layer of a given potential density range, can more accurately estimate the subsurface thermal anomaly. This study focuses on the interannual variability of the IPOHC in the subtropical northeast Pacific, a region crucial for extratropical‐tropical oceanic exchange. The IPOHC in the 24.8–25.6 kg/m3 potential density layer exhibits a significant interannual variability with a 5–6‐year period. Subduction and salt fingering are identified as key processes driving this variability. Specifically, increased subduction volume and enhanced salt fingering both can induce positive IPOHC anomalies, while the opposite results in negative anomalies. Late winter variations in subduction volume and salt fingering strength, which originate from the winter mixed layer depth variability and halocline intensity variability, work together to cause the observed interannual IPOHC anomalies. We emphasize that the subduction‐induced IPOHC anomalies are determined by anomalous subduction volume rather than mixed layer temperature. Furthermore, salt fingering plays an essential role in driving substantial IPOHC anomalies in the deep, poorly‐ventilated halocline/thermocline.
Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration
Authors: Zhang Xinshu , Xiao Yao , Hu Bo , Li Yanhao , Zhang Shaoyang , Tian Jian , Wang Shuo , Tao Zaijin , Zeng Xinqi , Liu Ning-Ning , Li Baojie , Liu Shen
Published: May 2024

Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies, resulting in severe disability. Macrophages are widely recognized as a fibrotic trigger during peritendinous adhesion formation. However, different clusters of macrophages have various functions and receive multiple regulation, which are both still unknown. In our current study, multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon injury. The transcriptomes of over 74 000 human single cells were profiled. As results, we found that SPP1+ macrophages, RGCC+ endothelial cells, ACKR1+ endothelial cells and ADAM12+ fibroblasts participated in tendon adhesion formation. Interestingly, despite specific fibrotic clusters in tendon adhesion, FOLR2+ macrophages were identified as an antifibrotic cluster by in vitro experiments using human cells. Furthermore, ACKR1 was verified to regulate FOLR2+ macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26RtdTomato mice to lethally irradiated Ackr1−/− mice (Ackr1−/− chimeras; deficient in ACKR1) and control mice (WT chimeras). Compared with WT chimeras, the decline of FOLR2+ macrophages was also observed, indicating that ACKR1 was specifically involved in FOLR2+ macrophages migration. Taken together, our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis, but also uncovered a novel antifibrotic cluster of macrophages and their origin. These results provide potential therapeutic targets against human tendon adhesion.
A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
Authors: Cheng Yu-Che , Acedera Jack Dalit , Li Yi-Ju , Shieh Sheau-Yann
Published: May 2024

Obesity is endemic to many developed countries. Overweight or obesity is associated with an increased risk of developing cancer. Dysfunctional adipose tissue alters cancer cell proliferation and migration; however, whether and how neoplastic epithelial cells communicate with adipose tissue and the underlying mechanism are less clear. BTG3 is a member of the anti-proliferative BTG/Tob family and functions as a tumor suppressor. Here, we demonstrated that BTG3 levels are downregulated in basal cell carcinoma and squamous cell carcinoma compared to normal skin tissue, and Btg3 knockout in mice augmented the development of papilloma in a mouse model of DMBA/TPA-induced skin carcinogenesis. Mechanistically, BTG3-knockout keratinocytes promoted adipocyte differentiation mainly through the release of IL1α, IL10, and CCL4, as a result of elevated NF-κB activity. These adipocytes produced CCL20 and FGF7 in a feedback loop to promote keratinocyte migration. Thus, our findings showcased the role of BTG3 in guarding the interplay between keratinocytes and adjacent adipocytes, and identified the underlying neoplastic molecular mediators that may serve as possible targets in the treatment of skin cancer.
Imaging and ferroelectric orientation mapping of photostriction in a single Bismuth Ferrite nanocrystal
Authors: Mokhtar Ahmed H. , Serban David , Porter Daniel G. , Nisbet Gareth , Collins Steve , Bombardi Alessandro , Newton Marcus C.
Published: May 2024

The exploration of multiferroic materials and their interaction with light at the nanoscale presents a captivating frontier in materials science. Bismuth Ferrite (BiFeO3, BFO), a standout among these materials, exhibits room-temperature ferroelectric and antiferromagnetic behaviour and magnetoelectric coupling. Of particular interest is the phenomenon of photostriction, the light-induced deformation of crystal structures, which enhances the prospect for device functionality based on these materials. Understanding and harnessing multiferroic phenomena holds significant promise in various technological applications, from optoelectronics to energy storage. The orientation of the ferroelectric axis is an important design parameter for devices formed from multiferroic materials. Determining its orientation in the laboratory frame of reference usually requires knowing multiple wavevector transfer (Q-Vector) directions, which can be challenging to establish due to the need for extensive reciprocal-space searches. Our study demonstrates a method to identify the ferroelectric axis orientation using Bragg Coherent X-ray Diffraction Imaging (BCDI) measurements at a single Q-vector direction. This method involves applying photostriction-inducing laser illumination across various laser polarisations. Our findings reveal that photostriction primarily occurs as a surface phenomenon at the nanoscale. Moreover, a photo-induced crystal length change ranging from 30 to 60 nm was observed, consistent with earlier findings on bulk material.
Evaporation-induced self-assembled ultrathin AgNW networks for highly conformable wearable electronics
Authors: Qin Chu , Sun Qingyin , Chen Yu , Fahad Shah , Wu Jiaxin , Dong Yuxuan , Yu Hongyu , Wang Min
Published: May 2024

The flexibility and stability of transparent electrodes play a crucial role in the growing popularity of flexible devices, especially in potential wearable electronics. To date, various solution-coating techniques have been developed for fabricating silver nanowire (AgNW) flexible bioelectronics. However, achieving the orderly distributed patterns of AgNW without undesirable aggregations still poses a grand challenge. Here, an approach to realize regular patterned ultrathin AgNW networks on a freestanding electrospun PVDF-TrFE frame by evaporation-induced self-assembly is proposed. The patterning mechanism of evaporating AgNW colloidal suspension is investigated from experimental and theoretical analysis. The influence of evaporation-induced flow inside colloidal freestanding membranes on forming regular square hole-shaped arrays, selective deposition of AgNW, and aligning them along the artificial pinning array are addressed. Owing to the orderly arrangement of AgNW networks, the resultant flexible electrode achieves ultrathin thickness (about 5 μm), high optical transmittance (87.8%), and low sheet resistance (8.4 Ω·sq−1) with a relatively low dosage of AgNW (9 μg·cm−2). The electrode exhibits excellent durability during cyclic bending (50,000 times) and stretching (50% strain). The resistance remains virtually unchanged during 200 days in everyday environments. Furthermore, the excellent conformability and breathability of the flexible transparent electrode attached to the human skin demonstrates its potential application as an e-skin sensor. Our findings reliably urge a simple approach to underscore better outcomes with effective patterns by self-assembly of AgNW for highly conformal wearable electronics.
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms
Authors: Pétremand Rémy , Chiffelle Johanna , Bobisse Sara , Perez Marta A. S. , Schmidt Julien , Arnaud Marion , Barras David , Lozano-Rabella Maria , Genolet Raphael , Sauvage Christophe , Saugy Damien , Michel Alexandra , Huguenin-Bergenat Anne-Laure , Capt Charlotte , Moore Jonathan S. , De Vito Claudio , Labidi-Galy S. Intidhar , Kandalaft Lana E. , Dangaj Laniti Denarda , Bassani-Sternberg Michal , Oliveira Giacomo , Wu Catherine J. , Coukos George , Zoete Vincent , Harari Alexandre
Published: May 2024

A central challenge in developing personalized cancer cell immunotherapy is the identification of tumor-reactive T cell receptors (TCRs). By exploiting the distinct transcriptomic profile of tumor-reactive T cells relative to bystander cells, we build and benchmark TRTpred, an antigen-agnostic in silico predictor of tumor-reactive TCRs. We integrate TRTpred with an avidity predictor to derive a combinatorial algorithm of clinically relevant TCRs for personalized T cell therapy and benchmark it in patient-derived xenografts.
Deregulated DNA ADP-ribosylation impairs telomere replication
Authors: Wondisford Anne R. , Lee Junyeop , Lu Robert , Schuller Marion , Groslambert Josephine , Bhargava Ragini , Schamus-Haynes Sandra , Cespedes Leyneir C. , Opresko Patricia L. , Pickett Hilda A. , Min Jaewon , Ahel Ivan , O’Sullivan Roderick J.
Published: May 2024

The recognition that DNA can be ADP ribosylated provides an unexpected regulatory level of how ADP-ribosylation contributes to genome stability, epigenetics and immunity. Yet, it remains unknown whether DNA ADP-ribosylation (DNA-ADPr) promotes genome stability and how it is regulated. Here, we show that telomeres are subject to DNA-ADPr catalyzed by PARP1 and removed by TARG1. Mechanistically, we show that DNA-ADPr is coupled to lagging telomere DNA strand synthesis, forming at single-stranded DNA present at unligated Okazaki fragments and on the 3′ single-stranded telomere overhang. Persistent DNA-linked ADPr, due to TARG1 deficiency, eventually leads to telomere shortening. Furthermore, using the bacterial DNA ADP-ribosyl-transferase toxin to modify DNA at telomeres directly, we demonstrate that unhydrolyzed DNA-linked ADP-ribose compromises telomere replication and telomere integrity. Thus, by identifying telomeres as chromosomal targets of PARP1 and TARG1-regulated DNA-ADPr, whose deregulation compromises telomere replication and integrity, our study highlights and establishes the critical importance of controlling DNA-ADPr turnover for sustained genome stability.
Early thrombus detection in the extracorporeal membrane oxygenation circuit by noninvasive real-time ultrasonic sensors
Authors: Rim Gongmin , Hyun Kwanyong , Cho Deog Gon , Lim Zhongsoo , Lee Byungdoo , Kim Keunho , Yoo Ga young
Published: May 2024

Thrombus formation in extracorporeal membrane oxygenation (ECMO) remains a major concern as it can lead to fatal outcomes. To the best of our knowledge, there is no standard non-invasive method for quantitatively measuring thrombi. This study’s purpose was to verify thrombus detection in an ECMO circuit using novel, non-invasive ultrasonic sensors in real-time, utilizing the fact that the ultrasonic velocity in a thrombus is known to be higher than that in the blood. Ultrasonic sensors with a customized chamber, an ultrasonic pulse-receiver, and a digital storage oscilloscope (DSO) were used to set up the measuring unit. The customized chamber was connected to an ECMO circuit primed with porcine blood. Thrombi formed from static porcine blood were placed in the circuit and ultrasonic signals were extracted from the oscilloscope at various ECMO flow rates of 1–4 L/min. The ultrasonic signal changes were successfully detected at each flow rate on the DSO. The ultrasonic pulse signal shifted leftward when a thrombus passed between the two ultrasonic sensors and was easily detected on the DSO screen. This novel real-time non-invasive thrombus detection method may enable the early detection of floating thrombi in the ECMO system and early management of ECMO thrombi.
Longitudinal associations between women’s cycle characteristics and sexual motivation using Flo cycle tracking data
Authors: Mengelkoch Summer , Cunningham Katja , Gassen Jeffrey , Targonskaya Anna , Zhaunova Liudmila , Salimgaraev Rodion , Hill Sarah E.
Published: May 2024

In the current research, we used data from a sample of 16,327 menstrual cycle tracking app users to examine the association between menstrual cycle characteristics and sexual motivation tracked over 10 months of app use. Guided by past work that finds links between menstrual cycle characteristics related to conception risk and sexual motivation, we found that (a) between-women, shorter (r = − 0.04, p = 0.007), more regular cycles predicted small increases in sexual motivation (r = − 0.04, p = 0.001); (b) within-women, shorter cycles predicted greater sexual motivation that month (r = − 0.04, p < 0.001) and (c) the next month (βs: − 0.10 to − 0.06, ps < 0.001), but (d) changes in sexual motivation did not reliably precede changes in cycle length (βs: − 0.01 to 0.02, ps > 0.15). Within-woman analyses also revealed that (e) shorter cycles were followed by more frequent reports of fatigue (β = − 0.06, p < 0.001), insomnia (β = − 0.03, p < 0.001), and food cravings (β = − 0.04, p < 0.001). Together, results suggest that menstrual cycles characteristics and sexual motivation may covary together in ways that reflect changing investments in reproduction. Small effect sizes and lack of experimental control warrant cautious interpretations of results.