bluuebunny/crossref_metadata_2025 huggingface dataset:
INCREASING TEACHERS' CREATIVITY IN TEACHING THROUGH THE IMPLEMENTATION OF AUDIO VISUAL MEDIA IN SMP NEGERI 4 DUMAI
Authors: Suryani Leni
Published: March 2023

This paper is based on the teachers’ low creativity at SMP Negeri 4 Dumai. Therefore, it is necessary to take an action to overcome this problem through the implementation of audio-visual media. Based on the description regarding the identification and limitation of the problem, this paper is focused on increasing teacher creativity. Hence, the formulation of the problem is whether there is an improvement in teacher creativity through the implementation of audio-visual media at SMP Negeri 4 Dumai. In accordance with the background and formulation of the problem, this paper aims to increase the creativity of teachers in SMP Negeri 4 Dumai through the implementation of audio-visual media. This type of research is school action research (PTS) which aims to determine the success of teachers’ creativity improvement in teaching through the use of audio-visual media at SMP Negeri 4 Dumai. Based on the results of the analysis and discussion, it can be concluded that teacher creativity in teaching at SMP Negeri 4 Dumai can be increased through the use of audio-visual media. Thus, the teacher acceptance rate increased. Comparison of teacher creativity in teaching in cycle I increased in cycle II. If cycle I that achieved 65% was increased to 71.5% in cycle II.
BİLGİ EDİNME HAKKI VE ÖZEL HAYATIN GİZLİLİĞİ ÇERÇEVESİNDE TAPU SİCİLİNİN AÇIKLIĞI İLKESİ
Authors: ERKAN Vehbi Umut , ÖZSOY Rabia
Published: March 2023

Tapu sicili sistemine hâkim olan ilkelerden tapu sicilinin açıklığı ilkesine göre, tapu sicili herkese açıktır. Ancak, bir kimse başkasına ait tapu sicili bilgilerini incelemek ya da bu sicilden örnek almak isterse ilgisini inanılır kılması gerekir. 4982 sayılı Bilgi Edinme Hakkı Kanunu’na (BEHK) göre, Türk vatandaşı olan gerçek kişiler ile Türkiye’de tescilli tüzel kişiler, ilgisini inanılır kılmasına gerek olmaksızın hem kendisiyle ilgili hem de bir başkasıyla ilgili bilgiye veya belgeye kolaylıkla ulaşabilme imkanına sahiptir. Bilgi edinme hakkı ile tapu sicilinin açıklığı ilkesine ilişkin TMK m. 1020/II hükmü, kişinin kendisiyle ilgili tapu sicil bilgilerini istemesi halinde birbirini tamamlayıcı niteliktedir. Ancak, başkasına ait tapu sicil bilgilerinin istenmesi durumunda bilgi edinme hakkı ile TMK m. 1020/II hükmü arasında ilk bakışta bir çatışma varmış gibi görünmektedir. Bu nedenle her iki kurum arasındaki ilişki ve aralarında bir çatışma olup olmadığının değerlendirilmesi gerekmektedir. Bu bakımdan çalışmamızda, bilgi edinme hakkı ve tapu sicilinin açıklığı ilkesine ilişkin bilgilere yer verilerek, BEHK’de yer alan hükümlerle TMK m. 1020/II hükmünün arasındaki ilişki ve buna bağlı olarak TMK m. 1020/II hükmünün zımnen yürürlükten kalkıp kalkmadığı hususu değerlendirilmiştir.
TÜRKİYE’DE KADINLARIN SİYASAL HAKLARINI KAZANMASI VE SİYASAL TEMSİLDE KARŞILAŞILAN SORUNLAR
Authors: DOĞRU Derya
Published: March 2023

Kadınların insan hakları mücadelesi, eski çağlardan bu yana dünyada hüküm süren erkek egemen toplum yapısına karşı verilmektedir. Kadınların insan haklarına eşit olarak sahip olması ancak eşit bir yurttaş olarak tanınmasıyla mümkündür. Bu nedenle kadınların hak mücadelesi öncelikle siyasal hakların kazanımına yönelik olarak başlamıştır. Ancak kadınların siyasal haklarını hukuken kazanmaları eşit siyasal temsili sağlamamıştır. Kadınların siyasal haklarından etkili bir şeklide yararlanabilmeleri, eşit siyasal temsil edilmelerine ve karar alma mekanizmalarında yer almalarına bağlıdır. Buna rağmen toplumların ataerkil yapıları ve kadına olan bakış açıları nedeniyle kadınların siyasal alanda aktif rol alması mümkün olamamaktadır. Bunun için kadınların insan haklarının ve konumuz özelinde siyasal haklarının kullanımında karşılaşılan sorunların toplumsal cinsiyet kavramından bağımsız olarak incelenemeyeceği açıktır. Dünya genelinde karşılaşılan eşit temsil edilememe sorununun aşılabilmesi için özellikle gelişmiş demokratik ülkelerde zorunlu cinsiyet kotası uygulanmaktadır. Ülkemizde kadınların siyasal haklarına 1934’den bu yana anayasal olarak sahip olmasına rağmen, eşit siyasal temsili sağlayacak zorunlu cinsiyet kotasının benimsenmemesi demokrasimizin önünde önemli bir engel olmaya devam etmektedir.
AGROECOLOGICAL TESTING OF ALFALFA
Authors: Ivanova Elena
Published: March 2023

The article presents data on agroecological testing of alfalfa in the conditions of Sakhalin Island. It was found that the maximum height of plants at the end of the growing season of the first year of life was noted in alfalfa of the Voronezhskaya 6 variety, and the greatest leafiness was in the Uralochka variety. In the second year of life, the Agnia VIK variety was clearly distinguished in height in the first mowing, and in the second mowing — Nakhodka and Agnia VIK. In terms of foliage, both in the first and in the second mowing, the Uralochka variety had an advantage. The total collection of green mass for two mowing was 98.7–130.1 t/ha in the experiment. The three leaders included varieties Taisiya, Sarga and Nakhodka.
QUALITY OF RAW MASS OF EARLY AND MID-MATURING GRASS STANDS FOR HAY PRODUCTION
Authors: Zhezmer Natalya
Published: March 2023

An assessment is made of the quality of herbal raw materials obtained on differently maturing cereal two-cut hayfields of the 24th–28th years of use when cutting N45RK. The quality of raw materials for hay harvesting was assessed by cuttings in accordance with Interstate standard according to the concentration of crude protein, crude fiber, the content of exchangeable energy in 1 kg of dry matter and the provision of one feed unit with digestible protein.
SCIENTIFIC SUPPORT OF FIELD FODDER PRODUCTION RUSSIA: ACHIEVEMENTS AND PROSPECTS
Authors: Shpakov Anatoly
Published: March 2023

An analysis of trends in the production of fodder on field lands in modern conditions is given, scientific achievements in the field of field fodder production are summarized, allowing the production of the necessary volumes of high-quality fodder, the main factors and organizational and technological measures of intensification, the main risks associated with their implementation, are substantiated. perspective directions of researches are defined. The role of the All-Russian Research Institute of Feed named after V. R. Williams in the scientific support of the field forage production in Russia.
VESTIDO DE NOIVA - O TEXTO FUNDADOR
Authors: Dória Lilian Fleury
Published: March 2023

Análise do surgimento do drama moderno brasileiro com a peça Vestido de Noiva deNelson Rodrigues, texto fundador de uma linhagem no teatro brasileiro, onde os vetores memória,tempo e linguagem são investigados numa narrativa não - linear. A análise abrange as relações doteatro com a sociedade brasileira, com a história e com a psicanálise. A fim de investigar odesnudamento da sociedade brasileira presente nesta peça, completa-se a análise com aindagação a respeito de personagens e do espaço cênico. As relações entre encenação e escritadramática são analisadas neste artigo, compreendendo o papel significativo da palavra no teatroaliada ao movimento e à vitalidade que cada encenação poderá trazer.PALAVRAS-CHAVE: drama moderno; teatro brasileiro; teatro brasileiro; memória; tempo;linguagem.
DAS ORIGENS DA FESTA À BRASILEIRA
Authors: Lopes Mônica de Souza
Published: March 2023

Este texto reflete sobre a festa à brasileira, suas formas de sociabilidade, as duas grandescategorias do festejo. Aponta a festa organizada pelo poder – Estado e Igreja – e aquela perpretada pelopovo. O estudo desenvolve ainda o histórico da festa nas terras daqui; o que provocou os festejos; porque se festejava e como aconteciam as comemorações, além de apontar como o povo apropriou-se dafesta e fez dela também um intercâmbio entre as diversar camadas populares. E mais: este texto discutea festa como expressão do sagrado e do profano, as caracterí­sticas de cada uma dessas facetas e ainterrelação entre elas.PALAVRAS-CHAVE: festa; poder; sociabilidade
QUANDO A MÚSICA ENTRA EM RESSONÂNCIA COM AS EMOÇÕES: SIGNIFICADOS E SENTIDOS NA NARRATIVA DE JOVENS ESTUDANTES DE MUSICOTERAPIA
Authors: Wazlawick Patrícia
Published: March 2023

Estudaram-se os significados e sentidos expressos nas narrativas que os jovensconstroem sobre sua história de relação com a música. Trabalhou-se com a "Entrevista Narrativa" (Schütze, 1977) focada na "Autobiografia Musical" (Ruud, 1998). As situações vividas deram margempara a construção dos significados da música nos contextos coletivos e singulares. Significados quesão constituí­dos pelos sentidos envoltos as emoções, sentimentos, desejos, interesses, motivaçõesde sujeitos em constantes relações com o contexto sócio-cultural. Significados/sentidos quedemonstram a utilização viva da música e a movimentação de sujeitos implicados com a atividademusical, que a constituem enquanto ela também se faz constituinte deles.PALAVRAS-CHAVE: significados e sentidos; significação musical; Musicoterapia.
NOTAS SOBRE A LEGITIMAÇÃO DA ARTE
Authors: Kaminski Rosane
Published: March 2023

O objetivo deste artigo é apresentar ao leitor alguns traços gerais sobre o fenômeno dalegitimação dos objetos de arte através do olhar constituí­do pela sociologia da arte. Sem deter-se nasespecificidades da linguagem artí­stica, o foco de interesse desta disciplina direciona-se ao aspectosocial da prática artí­stica, à compreensão das relações de poder e de funções simbólicas que seestabelecem entre os artistas, as obras, os crí­ticos, os marchands, o público, e as instituiçõesenvolvidas com estas pessoas e com estas obras.PALAVRAS-CHAVE: sociologia da arte; artes plásticas; legitimação da arte.
No princí­pio eram ossinhos de rena: para se compreender o saxofone no universo dos sopros
Authors: Sá Chico
Published: March 2023

Este artigo fala dos instrumentos de sopro e seus princí­pios acústicos básicos . Refletetambém que junto com os diversos aperfeiçoamentos durante a primeira metade do século XIX, surgeo sistema de chaves de Theobald Boehm e finalmente o saxofone de Adolphe Sax . O artigo apresentaainda figuras que ilustram as diversas fases dos instrumentos .PALAVRAS-CHAVE: saxofone, instrumentos de sopro, Theobald Boehm, Adolphe Sax.
MACROMUDANÇAS DE UM CORPO PÓS-HUMANO-MODERNO
Authors: Wosniak Cristiane
Published: March 2023

Este artigo se propõe a investigar as relações entre corpo e tecnologia: a dança comotexto hí­brido. Também serão abordados os conceitos de interface, hipertexto e interatividade destecorpo pós-humano-moderno como superfí­cie de uma nova escrita, de uma provável re-semantizaçãoda linguagem dança mediada pelo advento das novas tecnologias digitais. Sob a forma de um reactionpaper, diferentes e opostas teorias serão analisadas a fim de se averiguar como os conceitos deinteratividade, representação e referencialidade da imagem-corpo que dança são apresentadosenquanto dissolução de fronteiras entre arte e tecnologia, entre o corpo de carbono e o corpo de silí­cio,o real e o virtual.PALAVRAS-CHAVE: corpo; tecnologia; interatividade; interface; dança
A PALAVRA GERADORA DA AÇÃO DRAMÁTICA
Authors: Dória Lílian Fleury
Published: March 2023

A especificidade do texto dramático e as possibilidades de encenação podem ter umacomplexidade maior a partir das rupturas e cortes que o texto inaugura. Para analisar essa proposiçãoa autora contrapõe uma peça de teatro e um roteiro de cinema criados no Brasil e as possibilidades deencenação que esses textos possibilitam.PALAVRAS-CHAVE: dramaturgia; encenação; cinema brasileiro; teatro brasileirocontemporâneo.
PERSPECTIVAS PARA O TEATRO NA EDUCAÇÃO COMO CONHECIMENTO E PRÁTICA PEDAGÓGICA
Authors: Cavassin Juliana
Published: March 2023

O presente artigo objetiva demonstrar que o Teatro na Educação, apesar de serconsiderado uma área do conhecimento, em função de uma série de dificuldades teóricas e práticasainda precisa do desenvolvimento de bases sólidas e profundas para uma maior estabilidade dentro deum paradigma cientí­fico. É considerada a importância do foco nos campos de atuação da Pedagogia doTeatro, sobretudo na educação formal (Educação Infantil, Ensino Fundamental, Ensino Médio e osCursos Superiores) já que esses estão diretamente ligados aos locais de formação humana e produçãodo conhecimento. Em longo prazo, há uma influência direta aos demais campos de atuação do Teatrona Educação e diminuição das fragilidades apresentadas nessa área do conhecimento. Nesse sentido,argumenta-se sobre a fundamental importância da informação e do questionamento a respeito de açõesefetivas do Estado ligadas ao ensino do Teatro (com foco nos Parâmetros Curriculares Nacionais) etambém a formação de professores dentro de uma perspectiva do Pensamento Complexo e daEducação Progressista.PALAVRAS-CHAVE: arte e ensino; Parâmetros Curriculares Nacionais; formação de professores.
LINGUAGENS CÊNICAS: O ESPETÁCULO PICO NA VEIA DE MARCELO MARCHIORO
Authors: Camati Anna Stegh
Published: March 2023

A adaptação cênica de textos não dramáticos é uma prática bastante difundida nacontemporaneidade. No espetáculo Pico na Veia, a teatralidade consiste do jogo dos atores quepotencializa o universo narrativo de Dalton Trevisan. Seguindo a linha da simplicidade degrandes encenadores, Marcelo Marchioro lançou mão de uma estratégia de máscara que remontaaos primórdios da civilização. Os atores são, ao mesmo tempo, narradores-protagonistas de suashistórias e espectadores das narrativas que os outros contam, enquanto a platéia tem a função deouvinte e testemunha desse equilí­brio delicado. O êxito do espetáculo depende da cumplicidadetotal não somente entre palco e platéia, porém entre o próprio elenco como ensemble. Nesteartigo, investigo as linguagens cênicas que permitiram a bem sucedida transposição para o palcode contos e haicais de Dalton Trevisan.PALAVRAS-CHAVE: poéticas do contemporâneo, adaptação cênica, textos não dramáticos,teatralidade.
ESTÉTICA INDÍGENA JÊ NO PARANÁ: TRADIÇÃO E MUDANÇA NO ACERVO DO MUSEU PARANAENSE
Authors: Parellada Cláudia Inês
Published: March 2023

Neste artigo discute-se a estética de dois grupos indí­genas Jê no Paraná: Kaingang eXokleng através do acervo arqueológico e etnográfico do Museu Paranaense, inaugurado em 1876 emCuritiba. A análise conjunta de dados históricos e do patrimônio material do museu, e sobre comoesses objetos foram incorporados e são gerenciados na instituição, permitiu a revisão de materiais deorigem duvidosa. No estudo buscou-se a construção de um banco de dados sobre a estética indí­genaJê no Paraná, com aspectos diagnósticos que evidenciam os saberes tradicionais desses grupos e asmudanças que ocorreram.PALAVRAS-CHAVE: estética indí­gena Jê, arte indí­gena, arqueologia paranaense
INSTITUIÇÕES CULTURAIS: GÊNERO, NARRATIVAS E MEMÓRIAS
Authors: Vaz Adriana
Published: March 2023

Neste artigo, são discutidas as várias funções atribuí­das ao museu ao longo da suatrajetória como instituição de conhecimento, cultura e lazer. Dentre as considerações teóricaspertinentes à Sociologia da Arte, discute-se sua abrangência tendo como objeto de estudo asinstituições no campo da arte. Empiricamente, o foco é a pesquisa de gênero, ou seja, atransmissão da produção feminina nas artes visuais comparando três espaços de legitimação:o Museu Oscar Niemeyer (MON), as pastas [arte br] produzidas pelo Instituto Arte na Escolapólo UNICENTRO/PR e o Livro Didático de Arte adotado pelo Estado do Paraná para oEnsino Médio.PALAVRAS-CHAVE: sociologia da arte; produção feminina; público; museu.
BRECHTIANISMO CIRCENSE: TRADIÇÃO OU MODERNIDADE?
Authors: KrÃ¼ger Cauê
Published: March 2023

Este artigo examina a expressão circense no panorama teatral brasileiro partindo dacontribuição do Grupo Mambembe e do Teatro do Ornitorrinco. Para isto, procura demonstrar osurgimento de duas tendências opostas de utilização do circo no teatro: uma voltada ao resgatede sua tradição e outra como caminho para a modernidade. Os efeitos de associaçãopossibilitados pelo circo no teatro, seja em sua busca pela expressão popular, seja na atuaçãoperformática, são por fim relacionados à crí­tica brechtiana do palco italiano e da representaçãoilusionista.PALAVRAS-CHAVE: Teatro brasileiro; circo-teatro; novo circo; performance.
SOBRE A DIGNIDADE HUMANA NO PROCESSO DO MORRER
Authors: Dreher Sofia
Published: March 2023

Neste artigo, reflito sobre a dignidade humana no processo do morrer. Abordo discussõesbioéticas sobre o findar da vida humana. A mudança do paradigma da cura para o cuidado reflete umaimportante transformação de atuação das equipes de saúde, onde se insere o profissional damusicoterapia. É necessário criar unidades de cuidados paliativos que venham a atender e a respeitar adignidade humana dos pacientes terminais, fora de possibilidades terapêuticas, segundo um modelorelacional de atendimento.PALAVRAS-CHAVE: dignidade humana; morte; cuidados paliativos; bioética.
QUAL O LUGAR DA ARTE NO CURRICULO ESCOLAR?
Authors: Canda Cilene Nascimento , Batista Carla Meira Pires
Published: March 2023

Este artigo oferece reflexões sobre a importância da arte na educação, analisando ocurrí­culo enquanto campo de organização dos saberes educacionais, artí­sticos e culturais. Emcontraposição a um tipo de educação intelectualista, este estudo tece a discussão em torno da arte,enquanto atividade humana que propicia uma formação integral dos sujeitos no contexto social.Abordamos a inclusão da arte no currí­culo escolar, por considerar a criatividade e a sensibilidadecomo aspectos importantes para a formação pessoal e social. Por fim, compreendemos que a arte deveocupar lugar de destaque no currí­culo escolar, visando a formação estética, crí­tica e social doindiví­duo, na busca por uma sociedade mais justa e humanitária.PALAVRAS-CHAVE: arte-educação; currí­culo; formação integral.
RECURSOS METAFILMICOS EM BOCA DE LIXO, DE EDUARDO COUTINHO
Authors: Foster David William
Published: March 2023

Boca de lixo é um dos documentários mais importantes de Eduardo Coutinho. Este artigoexamina os recursos metafilmicos por ele utilizados: a voz narrativa; a incorporação do diretor e daequipe técnica de filmagem no texto visual; a incorporação dos habitantes do lixão enquanto eles seveem sendo filmados e enquanto se veem na e após a filmagem; o uso de sons de fundo; o uso de fotosjustapostas. É importante frisar que esses recursos não constituem um impulso estetizante deCoutinho. Servem, sim, para revelar a complexidade das experiências humanas vividas que vão sendomostradas.PALAVRAS-CHAVE: Boca do lixo; Eduardo Coutinho; recursos metafí­lmicos; experiênciashumanas.
O CINEMA VERDADE DE JEAN ROUCH NO FILME DI CAVALCANTI DI GLAUBER
Authors: Baggio Eduardo Tulio
Published: March 2023

Este texto propõe uma análise do filme Di Cavalcanti di Glauber, dirigido por GlauberRocha em 1976, sob o ponto-de-vista das teorias do cinema documentário. A análise percorre ocaminho do reconhecimento das influências que Glauber Rocha e o Cinema Novo receberam. Taisinfluências aparecem na realização de um documentário especí­fico que mostra caracterí­sticas deinteração, ou do Cinema Verdade, e que corresponde, em especial, aos pressupostos estabelecidos porJean Rouch. O próprio modo de realização de Di Cavalcanti di Glauber, com a intervenção no enterro,os comentários de Glauber e a controvérsia gerada indicam o caminho interativo descrito teoricamentepor Manuela Penafria.PALAVRAS-CHAVE: documentário; teorias do cinema; Glauber Rocha.
A ESTRELA QUE DEVERIA TER SIDO E NÃO FOI
Authors: Ayres Ivonir Rodrigues , Lima Marcos Hidemi de
Published: March 2023

Este artigo analisa a adaptação cinematográfica efetuada por Suzana Amaral doromance A hora da estrela, escrito por Clarice Lispector, cujo enredo apresenta o narradorfundido contraditória e simultaneamente em escritor, personagem e narrador das desventurasde sua personagem Macabea, uma jovem alagoana que vive no Rio de Janeiro. Ao sepreocupar em enfatizar as agruras dessa datilógrafa semi-alfabetizada, ignorante e pobre, ofilme acaba mostrando certos estereótipos do cinema brasileiro que frequentemente associapobreza à sujeira e à vulgaridade.PALAVRAS-CHAVE: A hora da estrela, romance, cinema.
Arte relacional e regime estético: a cultura da atividade dos anos 1990
Authors: Fabbrini Ricardo Nascimento
Published: March 2023

O artigo mostra que na arte relacional, na expressão de Nicolas Bourriaud,dos anos 1990, é visí­vel a tentativa de embaralhar arte e vida, o que a remete aoimaginário das vanguardas artí­sticas do século 20. Procura, contudo, distinguir oprojeto moderno de superação da relação entre arte e vida desta proposta de "artecolaborativa" que tomamos como sintoma da arte contemporânea. Seu objetivo éassim examinar se essas "práticas colaborativas e interdisciplinares" que seaproximam do mundo da vida " segundo também Jacques Rancière e Hans Obrist "articulam os elementos do presente no gesto estético ou na forma artí­stica " de modoa relacionar, na metáfora, estética e polí­tica " ou se essas práticas, ao contrário,atestam a neutralização da poética e o desvanecimento da polí­tica. Para tantoindagamos, a partir de Jean Galard, se esses espaços substitutivos podem funcionarefetivamente como elementos de recomposição dos espaços polí­ticos, ou se elescorrem o risco de assumirem a função de seus substitutos paródicos; ou seja: se natentativa de suprir a ausência de polí­ticas sociais, o que terí­amos nos espaços de arterelacional é uma sociabilidade glamourizada, fictí­cia – um simulacro da sociabilidadedita real porque fundada na imprevisibilidade e nos conflitos.Palavras"chave: Arte contemporânea, Estética Relacional; Comunicação; Polí­tica;Curadoria.
Paisagens Digitais: Ensaio visual de digigravura
Authors: Santos Filho Alexandre Silva
Published: March 2023

É uma pesquisa de Artes Visuais que busca mostrar e refletir sobre o processo gráfico visual de construção de matrizes eletrônicas com base na obra de experimentação tecnológica para a elaboração de digigravuras na Amazônia. Parte-se da concepção da criação de gravuras digitais (feita no computador), cuja referência remete-se aos procedimentos da gravura histórica. O Experimental, a heurí­stica e o conhecimento teórico sobre gravura e a poética do fazer arte reúnem-se na metodologia, tomando como central a reflexão estética em Benjamin (1994) e Schiller (2002). O desafio é conseguir uma imagem caracterí­stica para designar no computador uma matriz virtual com possibilidades de produzir cópias do original. A digigravura, então, passa a ser a técnica mais emancipada e desenvolvida das artes gráficas, por que se encontra num sistema em que é permitido o confronto e o rompimento com a sacralização da obra ritual. Resultando em uma visualidade mediante os modos de exibição da gravura eletrônica na contemporaneidade: a imagem da arte reproduzida significa que é a reprodução de uma imagem de arte criada para ser reproduzida. Não basta ter a imagem na tela do computador, isso não é suficiente para verificar a qualidade da reprodução da matriz visual. É preciso, portanto, materializar o trabalho, pois a ligação entre o artista e a obra desmaterializada é a cópia, uma prova (PE e PA) com o auxí­lio da impressora eletrônica, codificada em um sistema de cor e/ou um anteparo para ser exibida.
The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
Authors: Dong Changchao , Tan Gang , Zhang Guangyan , Lin Wei , Wang Guanglin
Published: March 2023

The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.
Characterization of the oral and gut microbiome in children with obesity aged 3 to 5 years
Authors: Ma Ting , Wu Zeyu , Lin Jing , Shan Chao , Abasijiang Aisaiti , Zhao Jin
Published: March 2023

The ever-increasing global prevalence of obesity has trended towards a younger age. The ecological characteristics and changes of the oral and gut microbial community during childhood are poorly understood.In this study, we analyzed the salivary and fecal microbiota of 30 children with obesity and 30 normal weight children aged 3-5 years via third-generation long-range DNA sequencing,with the aim of understanding the structure of childhood microbiota and identifying specific oral and gut microbial lineages and genera in children that may be associated with obesity.The results revealed significant variation in alpha diversity indices among the four groups (Chao1: P < 0.001; observed species: P < 0.001; Shannon < 0.001). Principal coordinate analysis (PCoA) and nonmetric multidimensional scaling (NMDS) revealed significant differences in oral and gut microbial community structure between obesity and controls. The Firmicutes/Bacteroidetes (F/B) abundance ratios of oral and intestinal flora among children with obesity were higher than those of controls. The most abundant phyla and genera found in oral and intestinal flora were Firmicutes, Proteobacteria, Bacteroidetes, Neisseria, Bacteroides, Faecalibacterium, Streptococcus, Prevotella and so on. Linear discriminant analysis effect size (LEfSe) revealed higher proportions of Filifactor (LDA= 3.98; P < 0.05) and Butyrivibrio (LDA = 2.54; P < 0.001) in the oral microbiota of children with obesity, while the fecal microbiota of children with obesity were more enriched with Faecalibacterium (LDA = 5.02; P < 0.001), Tyzzerella (LDA=3.25; P < 0.01), Klebsiella (LDA = 4.31; P < 0.05),which could be considered as dominant bacterial biomarkers for obesity groups.A total of 148 functional bacterial pathways were found to significantly differ in the oral and gut microbiota among controls and obesity using PICRUSt 2. Most predicted functional pathways were clustered in biosynthesis. In conclusion, This work suggests there were significant differences in oral and gut microbiota in controls and obesity groups, microbiota dysbiosis in childhood might have significant effect on the development of obesity.
Shifting linguistic patterns in oyster restoration news articles surrounding the Deepwater Horizon disaster
Authors: Fitzsimmons-Doolan Shannon , Beseres Pollack Jennifer
Published: March 2023

Populations of the eastern oyster Crassostrea virginica are declining globally. With the loss of oysters, sustainable provision of natural resources and ecosystem services are also threatened. In 2010, the Deepwater Horizon (DWH) oil spill became the largest marine oil spill in history, imperiling coastal and marine habitats in the Gulf of Mexico. Whereas ecological restoration serves as an important tool in natural resource management, its success depends on achieving ecological objectives and meeting public expectations. However, little is known about how the public perceives ecological restoration—even less in the context of disasters. It has long been understood that mass media messaging helps shape public understanding. Documenting patterned representation of oyster restoration in mass media texts can help set goals, improve stakeholder communication, and ensure required support for restoration activities. To address this goal, this study asks, does newspaper language on the topic of oyster reef restoration change in relation to an environmental disaster? If so, how? A 1.1 million-word Deepwater Horizon Oyster Restoration (DHORN) Corpus—a comprehensive body of newspaper articles about oyster restoration from 3 national and 18 gulf-state newspapers—was developed for the period April 2008–April 2014. The distribution and deployment of collocates of oyster* across three DHORN subcorpora delimited by time (pre-, during, and post-Deepwater Horizon oil spill) were compared through iterative quantitative and qualitative analysis. Examination of salient collocates in use over time indicated an increase in the representation of oysters as quantifiable entities during/post-DWH; at the same time, there was a decrease in the representation of the roles of oyster* in the Gulf ecosystem. Furthermore, multiple propositions associating oysters and oyster restoration activity with DWH and oil spills were introduced into language use by the disaster and persisted for years afterwards. This association was not present pre-DWH. Understanding shifts in linguistic patterns of oyster restoration in news articles before, during, and after Deepwater Horizon can be used to deliberately refine communication between the conservation community and both journalists and policymakers to promote conservation initiatives.
Early detection and serial monitoring during chemotherapy-radiation therapy: Using T1 and T2 mapping cardiac magnetic resonance imaging
Authors: Tian Yaotian , Wang Teng , Tian Liwen , Yang Yucheng , Xue Chen , Sheng Wei , Wang Cuiyan
Published: March 2023

Purpose

To confirm the ability of native T1 and T2 values in detecting and monitoring early myocardial injuries of chest radiotherapy in neoplasm patients.

Materials and methods

Fifteen participants received non-anthracycline chemotherapy and chest radiotherapy, and 30 age/gender-matched controls were enrolled in this prospective study. Cardiac magnetic resonance scans were performed within 2 days, 3 months, and 6 months after chest radiotherapy. Myocardial native T1 and T2 values were measured in irradiated and nonirradiated areas. Meanwhile, the parameters of left ventricular function and left ventricular myocardial strain were obtained.

Results

There were no significant differences in left ventricular function, native T1, T2, and strain between patients and controls before chest radiotherapy. In 15 participants who were followed up for 6 months, there was a significant change only in left ventricular ejection fraction (LVEF) among baseline and the first follow-up (P = 0.021), while the adjusted P-value was higher than 0.05 after Bonferroni correction, as well as other parameters. Native T1 values were elevated at 3 and 6 months in irradiated areas compared with baseline (1,288.72 ± 66.59 ms vs. 1,212.51 ± 45.41 ms; 1,348.01 ± 54.16 ms vs. 1,212.51 ± 45.41 ms; P < 0.001 for both). However, T2 values only changed at 3 months in irradiated areas compared with baseline (44.21 ± 3.35 ms vs. 39.14 ± 1.44 ms; P = 0.006). Neither the native T1 nor T2 values changed in nonirradiated areas during the follow-up period (all P > 0.05). There were no significant differences in strain changes during the follow-up period (all P > 0.05).

Conclusion

Native T1 and T2 values elevated at 3 months after chest radiotherapy, whereas LVEF showed no significant change during the 6-month follow-up.
The association between micronutrient levels and diabetic foot ulcer: A systematic review with meta-analysis
Authors: Kurian Shilia Jacob , Baral Tejaswini , Unnikrishnan Mazhuvancherry K. , Benson Ruby , Munisamy Murali , Saravu Kavitha , Rodrigues Gabriel Sunil , Rao Mahadev , Kumar Amit , Miraj Sonal Sekhar
Published: March 2023

Background

Diabetic foot ulcers (DFU) are a major complication of diabetes mellitus (DM). Nutrient deficiencies are among the major risk factors in DFU development and healing. In this context, we aimed to investigate the possible association between micronutrient status and risk of DFU.

Methods

A systematic review (Prospero registration: CRD42021259817) of articles, published in PubMed, Web of Science, Scopus, CINAHL Complete, and Embase, that measured the status of micronutrients in DFU patients was performed.

Results

Thirty-seven studies were considered, of which thirty were included for meta-analysis. These studies reported levels of 11 micronutrients: vitamins B9, B12, C, D, E, calcium, magnesium, iron, selenium, copper, and zinc. DFU, compared to healthy controls (HC) had significantly lower vitamin D (MD: -10.82 14 ng/ml, 95% CI: -20.47, -1.16), magnesium (MD: -0.45 mg/dL, 95% CI: -0.78, -0.12) and selenium (MD: -0.33 µmol/L, 95% CI: -0.34, -0.32) levels. DFU, compared to DM patients without DFU, had significantly lower vitamin D (MD: -5.41 ng/ml, 95% CI: -8.06, -2.76), and magnesium (MD: -0.20 mg/dL, 95% CI: -0.25, -0.15) levels. The overall analysis showed lower levels of vitamin D [15.55ng/ml (95% CI:13.44, 17.65)], vitamin C [4.99µmol/L (95% CI:3.16, 6.83)], magnesium [1.53mg/dL (95% CI:1.28, 1.78)] and selenium [0.54µmol/L (95% CI:0.45, 0.64)].

Conclusion

This review provides evidence that micronutrient levels significantly differ in DFU patients, suggesting an association between micronutrient status and risk of DFU. Therefore, routine monitoring and supplementations are warranted in DFU patients. We suggest that personalized nutrition therapy may be considered in the DFU management guidelines.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=259817, identifier CRD42021259817.
A sustainable trend in COVID-19 research: An environmental perspective
Authors: Vadiati Meysam , Ghasemi Leyla , Samani Saeideh , Islam Md. Aminul , Ahmadi Arman , Khaleghi Saeid , Movarej Maryam , Gorgij Alireza Docheshmeh , Kisi Ozgur , Davoodi Shahla , Dhama Kuldeep , Tiwari Ananda , Bhattacharya Prosun
Published: March 2023

Coronavirus disease 2019 (COVID-19) has spread across the globe producing hundreds of thousands of deaths, shutting down economies, closing borders and causing havoc on an unprecedented scale. Its potent effects have earned the attention of researchers in different fields worldwide. Among them, authors from different countries have published numerous research articles based on the environmental concepts of COVID-19. The environment is considered an essential receptor in the COVID-19 pandemic, and it is academically significant to look into publications to follow the pathway of hot topics of research and upcoming trends in studies. Reviewing the literature can therefore provide valuable information regarding the strengths and weaknesses in facing the COVID-19 pandemic, considering the environmental viewpoint. The present study categorizes the understanding caused by environmental and COVID-19-related published papers in the Scopus metadata from 2020 to 2021. VOSviewer is a promising bibliometric tool used to analyze the publications with keywords “COVID-19*” and “Environment.” Then, a narrative evaluation is utilized to delineate the most interesting research topics. Co-occurrence analysis is applied in this research, which further characterizes different thematic clusters. The published literature mainly focused on four central cluster environmental concepts: air pollution, epidemiology and virus transmission, water and wastewater, and environmental policy. It also reveals that environmental policy has gained worldwide interest, with the main keyword “management” and includes keywords like waste management, sustainability, governance, ecosystem, and climate change. Although these keywords could also appear in other environmental policy-related research studies, the importance of the COVID-19 pandemic requires such comprehensive research. The fourth cluster involves governance and management concerns encountered during the pandemic. Mapping the research topics in different clusters will pave the way for researchers to view future potential ideas and studies better. The scope for further research needs from the perspective of environmental concepts is reviewed and recommended, which can expand the vital role and value of environmental sciences in alerting, observing, and COVID-19 prediction for all four clusters. In other words, the research trend would shift from qualitative studies and perspectives to quantitative ones.
Environment education: A first step in solving plastic pollution
Authors: Liu Jianli , Hu Zhubing , Du Fangfang , Tang Wei , Zheng Siting , Lu Shanzhou , An Lihui , Ding Jiannan
Published: March 2023

Plastic pollution has been today’s most highly visible environmental problem in the world. How to responsibly manage plastic waste to control and eliminate plastic pollution has been a global challenge. We have begun to address these issues and developed some science-based solutions and emerging technologies. However, tackling such an intractable challenge requires systematic solutions except for science-based and technology-based ones. Environmental education, fostering plastic pollution prevention within society’s educational system, will provide a powerful and feasible pathway at a low cost. Within this perspective, the value and the way forward of education in solving plastic pollution are primarily discussed. Environmental education, including school-level education for students, sustainable consumption behavior guidance, and pollution prevention education for the public, is the feasible, effective, and permanent resolution of plastic pollution in the future.
Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention
Authors: Han Xianfu , Lin Demin , Huang Weiwei , Li Dingpeng , Li Ning , Xie Xingwen
Published: March 2023

Objective: This paper briefly reviews the structure and function of NLRP3 inflammasomes, signaling pathway, relationship with synovitis in KOA, and intervention of traditional Chinese medicine (TCM) in NLRP3 inflammasomes as a means to improve its therapeutic potential and clinical application.

Method: Literatures about NLRP3 inflammasomes and synovitis in KOA were reviewed to analyze and discuss.

Result: NLRP3 inflammasome can activate NF-κB mediated signal transduction, which in turn causes the expression of proinflammatory cytokines, initiates the innate immune response, and triggers synovitis in KOA. The TCM monomer/active ingredient, decoction, external ointment, and acupuncture regulating NLRP3 inflammasomes are helpful to alleviate synovitis in KOA.

Conclusion: The NLRP3 inflammasome plays a significant role in the pathogenesis of synovitis in KOA, TCM intervention targeting the NLRP3 inflammasome can be a novel approach and therapeutic direction for the treatment of synovitis in KOA.
Cardiac and vascular complications in lupus: Is there a role for sex?
Authors: Corker Alexa , Learmonth Maya , Patrick David M. , DeLeon-Pennell Kristine Y. , Van Beusecum Justin P.
Published: March 2023

Systemic lupus erythematosus (SLE) is a common systemic autoimmune disorder and is characterized by autoantibody formation and subsequent immune complex deposition into target organs. SLE affects nearly nine women to every one man worldwide. Patients with SLE are at an enhanced risk for cardiovascular disease (CVD) morbidity and mortality. CVD is the leading cause of death worldwide and includes heart and blood vessel disorders, cerebrovascular disease, and rheumatic heart disease. Specific mechanisms by which cardiac and vascular pathophysiology develops in patients with SLE are still not fully known. Not only do we not understand this correlation between SLE and CVD, but there is also a critical gap in scientific knowledge on the contribution of sex. In this review, we will discuss the cardiac and vascular pathological disease states that are present in some patients with SLE. More importantly, we will discuss the potential mechanisms for the role of sex and sex hormones in the development of CVD with SLE.
Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
Authors: ElAbd Hesham , Bacher Petra , Tholey Andreas , Lenz Tobias L. , Franke Andre
Published: March 2023

The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies.
The impact of chronic rhinosinusitis on COVID-19 risk and outcomes: A systematic review and meta-analysis
Authors: Reda Abdullah , Lashin Basant Ismail , Alaaraj Mustafa Mohammad , Abouelkheir Moustafa , Ahmed Mahmoud Ibrahim , Shah Jaffer , El-Qushayri Amr Ehab
Published: March 2023

Background

The impact of chronic rhinosinusitis (CRS) and subsequent steroid therapy on acquiring COVID-19 and severe outcomes remains controversial. Therefore, we conducted this systematic review and meta-analysis to provide cumulative evidence regarding the risk of COVID-19 and the impact of steroid therapy, length of hospital stay, mechanical ventilation, and mortality among CRC patients.

Methods

We conducted a comprehensive electronic search strategy using the relevant keywords. The outcomes and risk factors of COVID-19 in CRS patients was estimated and compared to a healthy control group when applicable.

Results

A total of seven studies were included, with an estimated prevalence of 6.5% (95% confidence interval (CI): 2.5-15.7) for COVID-19 in the CRS group. COVID-19 prevalence did not differ between CRS and controls (odds ratio (OR): 0.92; 95%CI: 0.84-1.01; p = 0.08). Moreover, using steroid/immunosuppressive therapy did not significantly increase the risk of acquiring COVID-19 in CRS patients compared to the control group (OR: 3.31; 95%CI: 0.72-15.26; p = 0.12). Length of hospital stay, mechanical ventilation, and mortality rates were comparable between the two groups. Furthermore, we found that male sex, cardiovascular morbidity, renal diseases, and hypertension were inversely associated with COVID-19 infection (p < 0.01).

Conclusion

CRS had a neutral effect on acquiring COVID-19 and developing severe outcomes. However, further studies are needed.
SARS-CoV-2 spike antibody concentration in gamma globulin products from high-prevalence COVID-19 countries are transmitted to X-linked agammaglobulinemia patients
Authors: Raphael Allon , Shamriz Oded , Tvito Ariella , Magen Sophie , Goldberg Shmuel , Megged Orli , Lev Atar , Simon Amos J. , Tal Yuval , Somech Raz , Eisenberg Rachel , Toker Ori
Published: March 2023

Purpose

Patients with X-linked agammaglobulinemia (XLA) are characterized by humoral impairment and are routinely treated with intravenous immunoglobulin (IVIG). In this study, we aimed to investigate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in IVIG preparations harvested globally and evaluate the transfer of SARS-CoV-2 antibodies to the XLA patient.

Methods

A single-center, prospective cohort study was conducted in the period of November 2020 to November 2022. Clinical and laboratory data, specifically, SARS-CoV-2 spike IgG levels from the serum of 115 IVIG preparations given to 5 XLA patient were collected. Concurrently, SARS-CoV-2 spike IgG levels from the serum of the 5 XLA was collected monthly.

Results

Five XLA patients were evaluated within the study period. All were treated monthly with commercial IVIG preparations. A total of 115 IVIG treatments were given over the study period. The origin country and the date of IVIG harvesting was obtained for 111 (96%) of the treatments. Fifty-four IVIG preparations (49%) were harvested during the COVID-19 pandemic of which 76% were positive (>50AU/mL) for SARS-CoV-2 spike antibodies which were subsequently transmitted to the XLA patients in an approximate 10-fold reduction. SARS-CoV2 spike IgG was first detected in IVIG batches that completed their harvest date by September 2021. Positive products were harvested from origin countries with a documented prevalence over 2,000 per 100,000 population.

Conclusion

As the prevalence of COVID-19 infections rises, detection of SARS-CoV-2 spike IgG in commercial IVIG products increases and is then transmitted to the patient. Future studies are needed to investigate the neutralizing capabilities of SARS-CoV-2 IgG and whether titer levels in IVIG remain consistent as the incidence of infection and vaccination rates in the population changes.
Joining technology and biology to solve conservation problems through translocation in the endangered limpet Patella ferruginea
Authors: Espinosa Free , Maestre Manuel , García-Gómez José Carlos , Cotaina-Castro María Isabel , Pitarch-Moreno Carmen , Paramio Juan Manuel , Fort-Santa María Patricia , García-Estévez Natalia
Published: March 2023

The Anthropocene era is characterized by a biodiversity crisis, where many species are pushing to extinction, causing alteration of the stability in the ecosystems and loss of their services. In this context, the translocation of endangered species is a powerful resource in conservation as long as its goals and appropriateness are clearly stated and it matches unambiguous criteria. Patella ferruginea is one of the most endangered marine species in the Mediterranean, and several translocations have been made with limited results in terms of survival. A methodology that mimics the natural topography of the substrate in the donor population based on Artificial Inert Mobile Substrates (AIMS, 40x20x10 cm) is proposed for restocking purposes. Three different treatments were tested: on substrate, slope, and cantilever depending on the position in which the AIMS were deployed. A total of 660 AIMS were installed within the donor area. The installation of such AIMS did not negatively affect either donor or receiving populations. A total of 188 specimens were translocated in three different attempts in 2018, 2019, and 2020, and no mortality was observed during the translocation process that lasted 24 h. Survival through the medium and long-term for the translocated specimens ranged from 80.6 to 91.5% after one month, 55.5 to 80.9% after eight months, and 48.4 to 76.6% after one year, with survival in the control population being 91.6% after four months and 87.5% after one year. Overall, recruits showed higher survival values than adults, whereas substrate treatment hosted more specimens (both recruits and adults) than slope and cantilever ones, while recruits were more abundant on cantilever treatment. The methodology has been proven to be useful for restocking and reintroduction purposes between donor and receiving areas.