bluuebunny/crossref_metadata_2025 huggingface dataset:
Lanthanum Complex with Neridronic Acid: Synthesis and Properties
Authors: Galantsev A. V. , Drobot D. V. , Dorovatovsky P. V. , Khrustalev V. N.
Published: May 2019

Currently, various amino bisphosphonates are widely used in the treatment of many bone diseases. One of the most well-known complex compounds of neridronic acid (6-amino-1-hydroxyhexylidene-1,1- bisphosphonic acid) is sodium neridronate – a bisphosphonate, which is used to treat osteogenesis and Paget's disease. However, there is no data on compounds of neridronic acid with rare earth elements. A new complex of lanthanum with 6-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (I) was obtained and characterized by various physicochemical methods (chemical analysis, IR spectroscopy, solid-phase 31P NMR spectroscopy, optical microscopy, PCA, DTA). According to the research data the complex I has the composition {La[(H3N-(CH2)5-C(OH)(PO2(OH))2]2(H2O)2}[OH]·H2O and represents the coordination 1D-polymer due to two bridged phosphonic groups with lanthanum atoms in a tetragonal-antiprismatic environment. In a crystal, polymer chains form a 3D-frame porous structure by means of strong hydrogen bonds O─H ··· O and N─H ··· O with endless channels, available to include a variety of inorganic anions or small organic molecules. A study under the microscope showed that the sample is needle crystals (thin rods) of different lengths. The particle size distribution was obtained by laser diffraction, and the average particle size was determined: 50 µm in length and 2.5 µm in thickness.
Risks of the saltwater intrusion in the SaiGon, DongNai rivers in the context of climate change and sea level rise
Authors: Le Tuan Ngoc , Tran Kim Thi , Nguyen Phung Ky
Published: May 2019

This work aimed to assess the risk of the saltwater intrusion (SI) in main rivers in Ho Chi Minh City (HCMC) in the context of climate change by 2100 under scenarios of RCP4.5 and RCP8.5. By modeling and GIS methods, results showed that SI has been increasing and moving upstream. Differences in the salinity between the RCP4.5 and RCP8.5 scenarios could be only visible from the middle to the end of the 21st century. In Saigon river, for RCP4.5, corresponding to 2025, 2030, 2050, and 2100, the salt line of 0.25‰ would be 0.25km, 1.6 km, 4.09km and 6.22km, respectively from Hoa Phu pump station as compared to that of 0.75 km; 1.6km; 4.6 km and 8.6 km, respectively for RCP8.5. In Dong Nai river, from Hoa An pump station, the corresponding figures would be 3.7km; 4.9km; 7.7km; 11.7km according to RCP4.5 and 3.7km, 4.9 km, 8.1km, 12.6km according to RCP8.5. The research results provide an important basis for planning suitable adaptation solutions, ensuring local activities and production.
探讨语文角度下的小学语文阅读指导
Authors: 肖 秋
Published: May 2019

在小学语文教学中,阅读教学是其重要组成部分,通过科学的语文阅读教学,能够加深学生对所学内容的理解,增强对语文学习的兴趣,同時在学生阅读学习的过程中,也能够提升其他方面的能力,如识字能力、写作能力、口语表达能力,这对于全面提升小学生的语文素养是非常重要的,必须要予以重视。
国有企业人才培养的研究与探讨
Authors: 郭 志虎
Published: May 2019

知识经济时代,人才成为了国有企业战略发展的重要资源。尤其在企业间竞争不断加剧的市场经济条件下,国有企业面临着诸多挑战,必须要把人才培养当作头等大事来抓。面对如此激烈的市场环境,国有企业若要保持不败之地,就必须要对人才培养模式进行创新,使其跟上时代发展的步伐。本文首先介绍了当前我国国有企业人才培养中存在的问题,之后提出了国有企业人才培养可以采取的模式。
如何提高小学数学低段学生“解决问题”的能力
Authors: 赵 怡
Published: May 2019

数学教学过程当中解决问题是一大核心要素,是数学教学的昀终目标。为此,针对如何提高小学教学低段学生解决问题的能力进行探究有着非常重要的意义。
刍议网媒对高校管理沟通课程改革的启示
Authors: 檀 璐
Published: May 2019

网络媒体正处于高速的发展阶段,在信息传播、传播内容等方面相对传统媒体都有很大程度上的改变,人们更多的通过网络媒体获取自身需求的信息。高校管理沟通课程的主要教学目是让学生掌握沟通的方法和技能,培养学生书面和口头沟通表达能力。网络媒体的高速发展对于高校管理沟通课程起到了一定程度的影响。本文在以网络媒体信息传播的特征分析作为切入点,分析了网络媒体对高校管理沟通课程的多方面影响,昀后提出通过网络媒体促进高校管理沟通课程改革的具体策略。
"互联网+"背景下基于智能手机和智慧教室的混合教学模式探究
Authors: 张 嘉超
Published: May 2019

在社会经济不断进步与发展的21世纪,我国在实际对教学事业的相关内容进行有效深化的过程中,更加注重智能化技术的有效应用。在实际发展的过程中,互联网+的大背景为我们教学提供了重要的发展动力,可以充分利用智能手机、智慧教室,不断加强教学模式的有效创新。而本人在研究的过程中,主要是从加强混合教学模式的重要意义出发,在对相关内容进行系统探索的基础之上,不断探索提升教学发展水平的措施,从而更好的推动我国教育事业的不断进步与发展。
构建全员参与 全程覆盖 全方位推进的创新创业教育体系培养“我行 我能”的应用型人才
Authors: 聂 晓微 , 孙 永新 , 李 婷雪
Published: May 2019

沈阳城市学院作为中国顶尖民办大学之一,自办校以来便确立了建设“具有广阔国际视野,广泛应用信息技术,面向城市未来,服务城市发展”的一流应用型大学目标。围绕国家“大众创业、万众创新”的战略布局,2013年沈阳城市学院正式将“双创”教育写入《沈阳城市学院创建一流应用型大学行动纲要》和《沈阳城市学院人才素质培养方案》,率先提出“全员参与、全过程覆盖、全方位推进”的普惠式创新创业教育模式,近年来,学校逐步形成具有应用型大学特色的创新创业教育体系。并以此深化教育教学综合改革。
Visual perception in early childhood education [Percepción visual en la primera infancia educativa]
Authors: Orellana Garibaldi Loreleine Sorange , Vega Vilca Carlos Sixto , Condorchua Bravo Gladys Edith , Carpio Mendoza Janet
Published: May 2019

The objective of the research was to compare the level of visual perception in four-year-old children of the Innova Schools educational institutions in the districts of Rímac and San Martín de Porres. The research was biased with a quantitative approach of a basic type and with a non-experimental cross-sectional design of a comparative descriptive level. The sample was eighty. The technique was the observation and the checklist served as an instrument to collect the data through an inventory of visual perception TEORE, which was developed by the authors. The instrument was analyzed and accepted by three experts who validated the application; the reliability value was obtained with the KR20 test of 0.882. The result was a 100% achievement for the Innova Schools of Rimac and 97.5% for the San Martin de Porres. It was concluded that there are no significant differences in the variable visual perception in the four-year-old children of the educational institutions Innova Schools districts of Rímac and San Martín de Porres. Given this, it was concluded that the students of the Innova Schools of the Rímac campus have a better visual perception development than the students of the Innova Schools of San Martín; however, they could still strengthen this capacity.
Relationship Between Parenting Myths and Marital Satisfaction in Parents of Primary Schoolers
Authors: Shoaa Kazemi Mehrangiz , Narjes Omrani Seyyedeh , Mirzaei Zahra , Khatoon Sabuti Narges
Published: May 2019

Purpose: Parents’ myths about parenting are among factors affecting couples’ marital satisfaction. The present study aimed to investigate the association of parenting myths with marital satisfaction. Method: Parents of primary school students (3rd–5th grade) in Tehran, Iran, (n = 150) were recruited for the study via convenience sampling. Research tools included Seidi’s Parenting Myths Scale (2016) With 50 questions (α = .94) and ENRICH marital satisfaction scale(1998) with 47 questions . Multiple regression was used for data analysis. Results: significant association was found between parenting myths and marital satisfaction. In the best model, parent-child identity (β = -0.37), excessively calm parenting (β = 0.35), overemphasis on educational achievement (β = 0.28), separation of work and personal life (β = 0.22), and efficacy (β = 0.21) were best predictors of marital satisfaction. Conclusion: parenting myths affect marital satisfaction in different cultural contexts, which illustrates the role of culture and belief in each region on the satisfaction of families in that region.
Authorial Stance-Taking and Engagement by Iranian PhD Candidates of TEFL in Writing Their Dissertations
Authors: Ghadimi Gheidari Farrokh , Davoudi Mohammad , Ghaniabad Saeed , Zareian Gholamreza
Published: May 2019

Writing has a special role in academic society as most of the information is transferred though publications. It has various aspects and among them stance taking and engagement have received less attention. The current study aimed at investigating how Iranian PhD candidates take stance and engagement in their dissertations. The participants of the study included Iranian PhD candidates and corpus for text analysis contained PhD dissertations written by them. Discourse analysis was carried out on the corpus to identify stance taking and engagement based on the framework proposed by Hyland (2008). Overall, it was found that Iranian PhD candidates use all the elements of stance taking although some elements were more present than others. For instance, the use of stance makers of boosters like actually, believe(s), believed, certain, clear, definite, demonstrate(s), demonstrated, and establish were present in the dissertations about 12.38% while the use of self-mention like I, me, my, our, us, we, the researcher, and the researchers were present about 39.04% out of all instances of stance markers used by the PhD candidates. With regard to the engagement, it was found that all the engagement markers were present in the dissertation except engagement markers such as Questions and Directive (imperative). As in stance taking the elements of engagement were present with various degrees. For instance, the use of interjections like the use of word Key was 12.42% while that of modals such as have to, must, need, ought, and should was 59.62%. The results were discussed and their implications were presented.
A Poetic Re-Telling of the Orphic Myth: A Political Study of Denise Levertov’s “A Tree Telling of Orpheus”
Authors: Obed Rana Jabir
Published: May 2019

Modern poets, such as William Butler Yeats, Ezra Pound, William Carlos Williams, Edna St. Vincent Millay, and Rainer Maria Rilke, have used classical myths in a modern context to explain modern issues and to feed up from the rich material of Greek and Roman mythology. Denise Levertov takes the right of all authors to knock into the heart of Western and classical traditions and to reinvent them for her time. Though Levertov’s early poetry expresses her appreciation of nature and of the epiphanic moments of daily life, during the late 1960s her work became progressively concerned with political and social issues. She conveys her offense in poems of distress over Vietnam and of commonality with the alternative culture that opposed the war. Levertov insists upon the connectedness of public and private spheres. The Vietnam War was a major preoccupation of the youth movement of the 1960s, whose protests against it caused the occasional disruption of Levertov’s “A Tree Telling of Orpheus.” This paper aims to retell the Greek myth of Orpheus and his famous song of perception and revitalization, which includes all the aspects of life and rebirth, with a modern revision. Levertov compares the awaking trees captivated by Orpheus’s song along with the awakening of the revolutionary consciousness that lays at the heart of` the countercultural movement of the 1960s.
PERANAN ANALISIS LAPORAN KEUANGAN DALAM MENGEVALUASI KINERJA KEUANGAN PERUSAHAAN PADA PT. BANK JABAR BANTEN Tahun 2007 – 2009
Authors: Anwar Yuli
Published: May 2019

The purpose of this study was to determine the financial performance of PT Bank Jabar Banten in 2007 - 2009 using a comparison and analysis of financial ratio analysis. The results obtained, the conditions seen from the company 's liquidity position : the current ratio in 2009 decreased because although the amount of current assets increased during the year, but the amount of current liabilities for the year also increased, indicating that the measurement is easy and fast to join the new amount of cash and other current assets by current liabilities. This means that when the securities are sold and accounts receivable payments can be received, then the bank can repay its short-term liabilities. Conditions views of the company 's solvency position, although there is a decrease and an increase in the solvency ratio, but the changes are not so significant or can be said to be relatively stable. This could indicate that the company 's financial performance is good enough to settle its debts - debts. Condition when viewed from the position of company activity , fixed asset turnover and working capital turnover continues to increase each year due to an increase in the side that tends to balance income and fixed assets. Keywords : financial performance, liquidity position, solvency, activity position.
Berbagai Faktor Yang Berhubungan Dengan Perilaku Ibu Hamil Dalam Pemanfaatan Kartu Bpjs
Authors: Zakiah Rofiatun
Published: May 2019

Salah satu upaya kesehatan yang dilakukan pemerintah dalam meningkatkan derajat kesehatan yang optimal adalah dengan diadakannya Program Jaminan Kesehatan Nasional (JKN). Badan hukum yang dibentuk untuk menyelenggarakan program JKN disebut Badan Penyelenggara Jaminan Sosial (BPJS). Tujuan penelitian ini adalah untuk mengetahui berbagai faktor yang berhubungan dengan perilaku ibu hamil dalam pemanfaatan kartu BPJS di Puskesmas Kecamatan Pasar Rebo tanggal 14 - 18 Desember 2015. Desain penelitian ini bersifat deskriptif analitik kuantitatif dengan metode cross sectional. Instrumen penelitian ini berupa kuesioner. Populasi dan sampel yang digunakan adalah seluruh ibu hamil yang berada di ruang KIA yang berjumlah 65 orang. Data diolah dengan uji chi square. Dari hasil bivariat didapatkan hasil uji statistik, pengetahuan didapatkan hasil (P -Value = 0,029, OR : 4,091), sikap (P -Value = 0,019, OR : 0,183), ketersediaan puskesmas terhadap BPJS (P - Value = 0,035, OR : 3,740), keterjangkauan puskesmas terhadap BPJS (P -Value = 0,020, OR : 4,278), dukungan suami (P -Value = 0,035, OR : 3,740), petugas kesehatan (P - Value = 0,040, OR : 3,964). Dari hasil penelitian ini disimpulkan bahwa pengetahuan, sikap, ketersediaan, keterjangkauan, dukungan suami dan petugas kesehatan mempunyai hubungan yang signiikan terhadap perilaku ibu hamil dalam pemanfaatan kartu BPJS. Dan disarankan bagi petugas kesehatan di Puskesmas Kecamatan Pasar Rebo lebih meningkatkan informasi tentang BPJS untuk ibu hamil. Dan bagi ibu hamil karena kartu BPJS dapat mengurangi biaya ibu dalam kehamilan dan persalinan, maka pada ibu hamil disarankan untuk mendatarkan dirinya ke BPJS.
Kata Kunci: BPJS, Ibu hamil, Perilaku
Faktor-Faktor yang Berhubungan dengan Tingkat Kepuasan Pasien di Instalasi Radiologi Rumah Sakit Putri Hijau tahun 2017
Authors: Elvina Elvina
Published: May 2019

Penilaian konsumen pada kualitas pelayanan Rumah Sakit merupakan hal penting sebagai acuan dalam pembenahan pelayanan sehingga terciptanya suatu kepuasan pelanggan dan menciptakan suatu loyalitas dari konsumen. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan tingkat kepuasan pasien di instalasi radiologi Rumah Sakit Putri Hijau Tahun 2017. Jenis penelitian ini adalah survei yang bersifat kuantitatif  dengan penelitian Cross sectional. Populasi dalam penelitian ini adalah seluruh pasien di instalasi radiologi Rumah Sakit Putri Hijau bulan Juli-Agustus Tahun 2017 dan sampel sebanyak 267 orang. Metode analisa data dengan cara analisis univariat, analisis bivariat dan analisis multivariat dengan uji regresi logistik ganda. Hasil penelitian secara statistik menunjukkan akses ke rumah sakit, kecepatan pelayanan, sikap petugas, lama waktu hasil radiologi, kenyamanan, jenis pasien dengan tingkat kepuasan pasien (p< 0.05). Hasil uji regresi logistik berganda diketahui variabel yang berhubungan dengan tingkat kepuasan pasien adalah kecepatan pelayanan, sikap petugas, lama waktu hasil radiologi, dan jenis pasien. Kecepatan pelayanan merupakan faktor yang paling dominan berhubungan dengan tingkat kepuasan pasien. Disarankan pihak rumah sakit, membuat pelatihan kepada petugas kesehatan untuk meningkatkan kemampuan dalam melayani pasien agar pasien tidak menunggu lama, membuat papan pengumuman yang besar mengenai prosedur pelayanan di rumah sakit, dan dapat memberikan kepuasan utamanya dalam hal ini adalah kenyamanan, informasi, akses, dan waktu tunggu yang cepat untuk hasil radiologi sehingga pasien dapat memberikan penilaian jasa yang diberikan dan meningkatkan sikap yang ramah dan tanggap memberi informasi tentang pelayanan kesehatan.
Hechos estilizados del mercado de criptomonedas desde el enfoque de la eficiencia marginal del capital.
Authors: Urdaneta Montiel Armando José , Borgucci García Emmanuel Vitorio , Campuzano Vasquez John Alexander , Avilés Almeida Pedro Alexander
Published: May 2019

El presente estudio tiene como objetivo analizar el mercado de criptomonedas desde el enfoque de la teoría de la demanda de activos y dentro de ella de los retornos esperados, tomando en cuenta dos de las más importantes: el Bitcoin (minada) y el Ripple (no minada). En esta investigación exploratoria, analítica y descriptiva, se tomó en cuenta el precio del cierre, volumen de transacciones, capitalización en el mercado y cantidad de criptomonedas emitidas, utilizando las variaciones diarias en términos porcentuales. Los resultados obtenidos muestran que las monedas consideradas de acuerdo a sus variaciones de precios de cierre diario y cantidad de criptomonedas emitidas, evidencian una evolución que se ajusta a la ley de los rendimientos marginales decrecientes unos de los fundamentos de la teoría eficiencia marginal del capital; mientras en el caso de las variaciones diarias de la capitalización del mercado con respecto a las de criptomonedas emitidas, comportan una evolución creciente, inversamente a los precios de cierre.
ASSESSMENT OF PARENTS’ SATISFACTION WITH PRIMARY HEALTH CARE PROVIDED TO THEIR CHILDREN IN POLYCLINICS
Authors: Menshikova L I , Dyachkova M G , Mordovsky E A
Published: May 2019

Background. Patients' satisfaction with medical care as a "subjective" component of a medical organization rating can be distorted by some factors. The aim of this study was to identify factors related to the medical care process in children's polyclinics that determine the parents' satisfaction with primary health care provided to their children. Methods. The sociological study by means of questioning of 215 parents (mothers) of children patients (0-17 years old) who received medical care in children's polyclinics in Arkhangelsk was carried out. Parents' satisfaction with primary health care was assessed according to three criteria: organization of the children's polyclinics work, satisfaction with the service process, and the presence (absence) of additional financial expenses for medical drugs. Binary logistic regression analysis was used to identify factors associated with the parents' satisfaction with primary health care provided to their children. Results. A half of the respondents (55.8 %, 95 % CI: 49.4-62.0) was satisfied with primary health care provided to their children. The respondents' satisfaction with medical care was significantly influenced by factors related to their personal communication with the pediatricians and medical personnel. Long wait (more than 1 month) for laboratory and instrumental examinations, additional consultations with specialists were not statistically significantly associated with parents' satisfaction with primary health care. Conclusion. Results of the study help to understand the mechanism of the development of the "patients' satisfaction with medical care"; indicate that "the proportion of parents who are satisfied with medical care" is not an independent criterion for the quality of medical care in children's polyclinics. Parents' satisfaction with primary health care provided to their children is determined by factors related to the quality of personal contact with the pediatrician.
THE IMPACT OF THE REMEDIATED WASTES OF MINING PROCESSING PLANT ON CYTOGENETIC INDICES IN HEALTHY CHILDREN
Authors: Reutova N V , Reutova T V , Dreeva F R , Shevchenko A A
Published: May 2019

Environmental pollution with heavy metals and the effects of this pollution have remained challenging since long. Particular interest represents the effects of prolonged exposure to low doses of heavy metals. In order to determine the level of environmental pollution the content of heavy metals in drinking water, soils, pasture grasses, potatoes, and milk produced in the farms and in the hair of children was determined using x-ray fluorescence method and atomic absorption spectrophotometry. Children of primary school age from the vicinity of reclaimed tailing dump of tungesto-molybdic factory and clean zone were examined. To evaluate the cytogenetic status of the children the multisystemic karyological test was used. Soil, drinking water, potatoes and milk in the area of the reclaimed tailing dump were characterized by a low level of heavy metal pollution. There were no significant differences in the heavy metal concentration in children's body from both zones due to the high individual variability. The frequency of micronuclei (4,1 times), biomarkers of cell proliferation (1,5 times), destruction of cell nuclei (2 times) and frequency of apoptotic cells (1,2 times) was higher in children from polluted area. Thus, we identified an implicit genotoxic effect of disposed wastes on the child population living in close proximity to them, which led to a significant increase in the number of children belonging to the groups of medium and high risk.
ENDOECOLOGICAL MODEL OF RELATIONSHIP BETWEEN LIVER DYSFUNCTION AND LARGE INTESTINE DYSBIOSIS IN ACUTE ALCOHOLIC PSYCHOSIS
Authors: Solovieva N V , Karyakina O E , Bazhukova T A , Soloviev A G
Published: May 2019

The results of biochemical parameters evaluation of blood dynamics and large intestine endoecology in patients with a syndrome of dependence on alcohol are presented. Friendly changes in enzymatic activity of blood serum and quantitative content of the main microflora representatives of large intestine in patients with acute alcoholic psychosis (AAP) are identified. It was produced ranking indicators of serum enzymes, lipids, pigment metabolism with subsequent calculation of the deviations from the physiological norm limits. The total degree of deviation indicators was considered as independent variables, the relationship that reflects a comprehensive assessment of the functional state of the liver to the extent that the large intestine dysbiosis. A mathematical model of regression-type complex quantitative estimation of biochemical status and microbiocenosis rectum at the AAP, based on the scale level, which reflects the cumulative severity of the patient's existing endoecological violations in the values of the analyzed parameters is made. Dynamics assessment of analyzed indicators changes in the course of treatment has allowed to identify the most important biochemical and microbiological parameters for future inclusion as predictors of liver disease progression risk in the development in a mathematical model of the relationship reducing the effectiveness of liver detoxification and dysbiotic shifts the large intestine microflora. The proposed approach can be used to facilitate the evaluation of the recovery of liver function in the process of the treatment on the level of the share of the mutual influence of the recovery in the intestinal microbiocenosis quantitative variables.
USE OF GEOMETRIC METHODS OF ANALYSIS OF VIDEO-OCULOGRAPHIC DATA TO ASSESS THE FUNCTIONAL CONDITION OF A PERSON
Authors: Zakharchenko D V , Torshin V I , Sveshnikov D S , Radysh B B , Starshinov Y P , Yakunina E B , Shatalova L S
Published: May 2019

Objective. In article describes two original algorithms for the analysis of video-oculographic data and analyses the effectiveness of these algorithms to assess the current functional condition of a person. One of the algorithms is designed for estimating macrosaccades curvature and the other - to evaluate the smoothness of target tracking. Both algorithms are based on geometric methods of videooculographic data processing. Methods. The assess of the algorithms effectiveness was realized on the model of alcohol intoxication (used the medium doses of alcohol - 0.8 g of 96 % alcohol per 1 kg of body weight). For the simulation of saccadic movements and smooth tracking we developed two psychomotor tests, which were evaluated by two key indicators: the curvature of microsaccade and smooth target tracking. Results. The results showed that the operator's activity disorders were usually accompanied by disturbance of the smooth oculomotor tracking. However the significant changes in the curvature of macrosaccades were not observed. Conclusions. Indicators of the smooth oculomotor tracking turned out to be quite informative for assessing the functional state of a person during the activity and can be used for practical diagnosis. Indicators of curvature of microsaccade were not sufficiently sensitive to the negative external factors and can't be used for practical diagnosis of the current condition of the person.
STRUCTURAL DAMAGES OF HUMAN DNA OF PERIPHERAL BLOOD LYMPHOCYTES UNDER THE INFLUENCE OF PHYSICAL FACTORS
Authors: Tekutskaya E E , Vasiliadi R V
Published: May 2019

Increase of electromagnetic radiations level in the human environment is connected with the accelerated rates of information and communication development. At the same time, ability of peripheral blood lymphocytes of the irradiated persons to the adaptive response in long date after radiation allows to consider them as a biological marker of a functional status of these cells. The quantity of DNA single-strand breaks in peripheral blood lymphocytes affected by various physical factors: the microwave oven - gamma and laser radiation, and after lymphocytes incubating in the environment containing silver nanoparticles was defined by means of fluorescent spectroscopy. It is shown that with increase in microwave radiation frequency DNA quantity in lymphocytes increases in comparison with control samples: under the influence of radiation with a frequency of 3,5 GHz at 32,3 ± 0,9 %, with a frequency of 50 GHz at 40,1 ± 1,1 %, with a frequency of 70 GHz at 49,8 ± 0,7 %. Affection of 137Cs gamma rays preparation with 0,104 MBK activity induces dose-related increase of DNA single-strand breaks. Quantity increase of DNA single-strand breaks is observed after laser irradiation at the wavelength of 510,6 nm to 18,1 ± 0,7 % (irradiation time - 3 min) and to 6,1 ± 0,5 % (irradiation time -5 min), at the wavelength of 578,2 nm to 18,1 ± 0,7 % (irradiation time - 3 min) and to 22,3 ± 0,9 % (irradiation time - 5 min). DNA single-strand breaks quantity measurements after lymphocytes incubation in the normal saline containing silver nanoparticles showed that in the studied range of silver nanoparticles concentration with the diameter of 12 nm ± 10%(1,863 - 0,621 mkg/l) occur structural failure of DNA molecules. On the basis of the obtained data the conclusion has been made that DNA single-strand breaks count in the immune competent cells can become a tool for research of physical factors influence on a human body.
Styria Kalkınma Ajansı’nın (SFG) Yenilikçilik Faaliyetleri
Authors: ÇELİK Fatih
Published: May 2019

Bölgesel Kalkınma Ajansı (BKA), bölgesel kalkınmanın bir “katalizör”ü ve “destekleyici”si olarak aktörler arasında işbirliğini sağlamak, yerel kaynakları harekete geçirmek ve rekabet gücünü artırmak için kurulan bir örgüttür. BKA’lar, dünyada 1930’lardan; Avrupa’da ise, 1950’lerden itibaren kurulmaya başlamıştır. Avrupa’daki BKA’lardan bazıları, bölgesel kalkınmaya yönelik yenilikçilik faaliyetleri ile literatüre geçmiştir. Bunlardan biri, Avusturya’nın Styria bölgesinde 1991 yılında kurulan Styria Kalkınma Ajansı’dır (SFG).Çalışmanın amacı, SFG’nin yenilikçilik faaliyetlerini analiz etmektir. Konu, doküman analizi tekniği ile ele alınmıştır. Analiz sonucunda, SFG’nin yenilikçilik faaliyetleri kapsamında kümelenme, yenilik ve ağ faaliyetlerinde bulunduğu; bu faaliyetler ile “kurumsal yapı”lar kurduğu; bu “yapı”ları bir araya getirmek için de, Bölgesel Yenilik Sistemi (BYS) kurduğu tespit edilmiştir.
Variability in the Global Proso Millet (Panicum miliaceum L.) Germplasm Collection Conserved at the ICRISAT Genebank
Authors: Vetriventhan Mani , Azevedo Vania C.R. , Upadhyaya Hari D. , Naresh D.
Published: May 2019

Proso millet (Panicum miliaceum L.), also known as common millet or broomcorn millet, is an important ancient crop mostly grown for food, feed, and fodder purposes largely in China, Russia, India, and the USA. It is an under-researched and under-utilized crop. Over 29,000 germplasm accessions have been conserved in genebanks globally. Five races (miliaceum, patentissimum, contractum, compactum, ovatum) have been recognized in proso millet based on panicle morphology and shape. The genebank at the International Crops Research Institute for the Semi-Arid Tropics conserves 849 accessions of proso millet originating from 30 countries and represents all five races. Characterization of these germplasm accessions revealed large variability for morpho-agronomic traits, including for days to 50% flowering (26 to 50 days), plant height (20 to 133 cm), and inflorescence length (22 to 400 mm). On average, the race miliaceum was tall (62 cm) with long panicles (209 mm) and ovatum had short plants (46 cm) with small panicles (108 mm). The average Gower’s distance based on 18 morpho-agronomic traits on 841 accessions was 0.261. The race miliaceum had the highest among accessions within race average pairwise distance (0.254), while the distance was the lowest in ovatum (0.192). The races miliaceum and ovatum showed the highest divergence with each other (0.275), while the lowest divergence was observed between compactum and ovatum (0.229). Trait-specific sources were identified for early maturity, tall plants, long inflorescences, and greater seed size. The information on variability and trait-specific sources identified could potentially support proso millet improvement.
Histological and Comparative Transcriptome Analyses Provide Insights into Small Intestine Health in Diarrheal Piglets after Infection with Clostridium Perfringens Type C
Authors: Yan Zunqiang , Cai Lijuan , Huang Xiaoyu , Sun Wenyang , Li Shouhu , Wang Pengfei , Yang Qiaoli , Jiang Tiantuan , Gun Shuangbao
Published: May 2019

C. perfringens type C can induce enteritis accompanied by diarrhea and annually causes significant economic losses to the global pig industry. The pathogenic mechanisms of C. perfringens type C in pigs are still largely unknown. To investigate this, we challenged seven-day-old piglets with C. perfringens type C to cause diarrhea. We performed hematoxylin & eosin (H&E) staining of the small intestine (including duodenum, jejunum, and ileum) and assessed gene expression in the ileal tissue. H&E staining of the duodenum, jejunum, and ileum demonstrated inflammation and edema of the lamina propria and submucosa. A total of 2181 differentially expressed genes (DEGs) were obtained in ileal tissues. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis of DEGs indicated that the main pathways were enriched in the T cell receptor signaling pathway, NF-kappa B signaling pathway, and (tumor necrosis factor) TNF signaling pathway. These results provide insights into the pathogenicity of C. perfringens type C and improve our understanding of host–bacteria interactions.
Differential Expression of KCNJ12 Gene and Association Analysis of Its Missense Mutation with Growth Traits in Chinese Cattle
Authors: Cheng Jie , Peng Wenwen , Cao Xiukai , Huang Yongzhen , Lan Xianyong , Lei Chuzhao , Chen Hong
Published: May 2019

The potassium inwardly rectifying channel, subfamily J, member 12 (KCNJ12) gene is a promising candidate for economic traits because of its crucial roles in myoblast development. Here, a missense mutation (Cys > Arg) was first detected to be located in exon 3 of KCNJ12 from three Chinese cattle breeds by DNA-pool sequencing. Then, we performed an association analysis of this single-nucleotide polymorphism (SNP) with stature in three Chinese cattle populations (n = 820). A significantly positive correlation was revealed by a reduced animal general linear model and the CC genotype was the most favorable in three breeds. Further, we measured the expression profile of the KCNJ12 gene in various cattle tissues and primary bovine skeletal muscle cells. Ubiquitous expression with high abundance in muscle was observed. Further, in primary bovine skeletal muscle cells, the KCNJ12 mRNA expression was gradually up-regulated in differentiation medium (DM) compared with that in growth medium (GM), suggesting that the KCNJ12 gene is involved in bovine myocyte differentiation. Conclusively, the KCNJ12 gene is a functional candidate gene which can be used as a molecular marker for cattle breeding.
Framework and Application of a Big Data Monitoring System for Mining with a Pillar-Free Self-Forming Roadway
Authors: Tao Zhigang , Zheng Xiaohui , Zhu Chun , Zhang Haijiang , Zhang Xiulian
Published: May 2019

The construction of a self-formed roadway without coal pillars is a new mining technology based on short-arm beam formation through roof cutting. With it, mining, tunneling and retaining roadway construction can be accomplished in a ‘three-in-one’ process that removes the need to dig in advance at the working face and to leave behind coal pillars. In order to realize real-time monitoring and warnings regarding rock pressure during this process, a big data monitoring system was developed based on quasi-distributed fiber Bragg grating (FBG) sensing technology and cloud technology. Firstly, real-time monitoring data on the stress and strain of the underground surrounding rock-support system are obtained by FBG sensor and transmitted to the main computer of the above-ground monitoring and early warning system by using an underground industrial ring network. These data are then sent to a big data remote online real-time monitoring system. Through the deployment of a cloud server, authorized users can observe changes in force and movement in the rock surrounding the supporting system during coal mining and roadway formation from anywhere and at any time. The successful application of the system in the S1201-II working face of the Ning Tiaota Mine shows that this remote real-time monitoring system can enable timely and accurate field data acquisition, feedback real-time production information and achieve good monitoring performance. This study thus provides a scientific basis for ensuring safe mining with the coal pillar-free self-forming roadway method.
Topology Comparison Study of Five-Phase Wound-Field Doubly Salient Fault Tolerant Generators
Authors: Shi Liwei , An Junhao , Zhang Wenchao
Published: May 2019

To present the characteristics of pole number and pole shape of the core, the five-phase wound-field doubly salient generators (WFDSGs) with symmetric phase inductance are studied and optimised in this paper, considering the split ratio, slot fill factor and core fringing effect. Based on the principle and structure of the five-phase WFDSGs, the winding induced electro-motive force under different number of poles is theoretically analysed. The constraints for parameter optimisation design including slot fill factor, split ratio and magnetic density characteristic are given. The finite element models of 30/24-pole and 20/16-pole WFDSG are established, and the comparative simulation analysis is carried out. It is pointed out that when the inner and outer diameters of the stator and rotor, the axial length and the maximum magnetic density are constant, the induction electromotive forces of the WFDSGs with different pole numbers and same phase coil number are same. Considering the pole fringing effect, the rotor pole equivalent width is the sum of the rotor pole actual width and 4 times of the air gap. The comparison experiments between the 30/24-pole and 20/16-pole WFDSGs were carried out, which verified the correctness of the theoretical analysis and finite element analysis (FEA).
Dispersion of OH Radicals in Applications Related to Fear-Free Dentistry Using Cold Plasma
Authors: Shahmohammadi Beni Mehrdad , Han Wei , Yu K.N.
Published: May 2019

Cold atmospheric plasmas (CAPs) are being used in applications related to dentistry. Potential benefits include tooth whitening/bleaching, the sterilization of dental cavities, and root canal disinfection. Generated reactive species, such as hydroxyl (OH) radicals, play a critical role in the effectiveness of CAPs in dentistry. In the present work, the mandibular jaw and teeth were modeled. The propagation of CAP plume in ambient air was dynamically tracked using the level set method. The transport and dispersion OH radicals away from the nozzle and towards the teeth under treatment were also tracked. The distributions of concentration of OH radicals over the teeth were obtained for nozzle to tooth distances of 2 and 4 mm. The discharge of the OH radicals out of the nozzle was found to be asymmetrical. Interestingly, depending on the type of tooth treated, the dispersion of OH radicals out of the nozzle could be altered. The present model and obtained results could be useful for advancements towards a fear-free dentistry using CAPs.
Dual Stratified Nanofluid Flow Past a Permeable Shrinking/Stretching Sheet Using a Non-Fourier Energy Model
Authors: Safwa Khashi’ie Najiyah , Md Arifin Norihan , Hafidzuddin Ezad Hafidz , Wahi Nadihah
Published: May 2019

The present study emphasizes the combined effects of double stratification and buoyancy forces on nanofluid flow past a shrinking/stretching surface. A permeable sheet is used to give way for possible wall fluid suction while the magnetic field is imposed normal to the sheet. The governing boundary layer with non-Fourier energy equations (partial differential equations (PDEs)) are converted into a set of nonlinear ordinary differential equations (ODEs) using similarity transformations. The approximate relative error between present results (using the boundary value problem with fourth order accuracy (bvp4c) function) and previous studies in few limiting cases is sufficiently small (0% to 0.3694%). Numerical solutions are graphically displayed for several physical parameters namely suction, magnetic, thermal relaxation, thermal and solutal stratifications on the velocity, temperature and nanoparticles volume fraction profiles. The non-Fourier energy equation gives a different estimation of heat and mass transfer rates as compared to the classical energy equation. The heat transfer rate approximately elevates 5.83% to 12.13% when the thermal relaxation parameter is added for both shrinking and stretching cases. Adversely, the mass transfer rate declines within the range of 1.02% to 2.42%. It is also evident in the present work that the augmentation of suitable wall mass suction will generate dual solutions. The existence of two solutions (first and second) are noticed in all the profiles as well as the local skin friction, Nusselt number and Sherwood number graphs within the considerable range of parameters. The implementation of stability analysis asserts that the first solution is the real solution.
Chemical Bonding and Physical Properties in Quasicrystals and Their Related Approximant Phases: Known Facts and Current Perspectives
Authors: Maciá Barber Enrique
Published: May 2019

Quasicrystals are a class of ordered solids made of typical metallic atoms but they do not exhibit the physical properties that usually signal the presence of metallic bonding, and their electrical and thermal transport properties resemble a more semiconductor-like than metallic character. In this paper I first review a number of experimental results and numerical simulations suggesting that the origin of the unusual properties of these compounds can be traced back to two main features. For one thing, we have the formation of covalent bonds among certain atoms grouped into clusters at a local scale. Thus, the nature of chemical bonding among certain constituent atoms should play a significant role in the onset of non-metallic physical properties of quasicrystals bearing transition-metal elements. On the other hand, the self-similar symmetry of the underlying structure gives rise to the presence of an extended chemical bonding network due to a hierarchical nesting of clusters. This novel structural design leads to the existence of quite diverse wave functions, whose transmission characteristics range from extended to almost localized ones. Finally, the potential of quasicrystals as thermoelectric materials is discussed on the basis of their specific transport properties.
Differential Expression of CD3, TNF-α, and VEGF Induced by Olanzapine on the Spleen of Adult Male Albino Rats and the Possible Protective Role of Vitamin C
Authors: Youssef Sahar , Salah Marwa
Published: May 2019

Olanzapine is an antipsychotic drug effective in the treatment of stress-associated psychiatric illnesses, but its effect on the spleen remains unclear. Vitamin C is essential for the optimum function of the immune system. We aim to investigate the effect of Olanzapine on spleen structures and to assess the protective effect of vitamin C. Forty adult male albino rats were divided into four groups: group (I), a control; group (II), rats were given vitamin C at 40 mg/kg body weight; group (III), rats were given Olanzapine at 2 mg/kg body weight; and group (IV), rats were given vitamin C and Olanzapine at the same dose of group (II) and group (III) for one month. The hematoxylin and eosin (H&E) of the olanzapine treated group showed focal areas of cellular depletion and a decrease in the size of the white pulp. The red pulp was expanded and showed marked congestion and dilatation of blood sinusoids. Cluster of differentiation 3 (CD3) was significantly reduced, however both tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) were significantly higher. The administration of vitamin C repaired structural and immunohistochemical changes via increased CD3 and decreased TNF-α and VEGF. Therefore, the oxidative and the inflammatory pathways may be the possible mechanisms underlying olanzapine immunotoxicity. Vitamin C exerted immune modulator and antioxidant effects against olanzapine.
Comparison of Infrared Thermography and Heat Flux Method for Dynamic Thermal Transmittance Determination
Authors: Gaši Mergim , Milovanović Bojan , Gumbarević Sanjin
Published: May 2019

This paper proposes an alternative experimental procedure that uses infrared thermography (IRT) for measuring the surface temperature of building elements, through which it is possible to approximate the thermal transmittance or the U-value. The literature review showed that all authors used similar procedures that require semi-stationary heat transfer conditions, which, in most cases, could not be achieved. The dynamic and the average methods that are given in ISO 9869 were also used with the IRT and the heat flux method (HFM). The dynamic method (DYNM) shows a higher level of accuracy compared to the average method (AVGM). Since the algorithm of the DYNM is more complicated than that of the AVGM, Microsoft Excel VBA was used to implement the algorithm of the DYNM. Using the procedure given in this paper, the U-value could be approximated within 0–30% of the design U-value. The use of IRT, in combination with the DYNM, could be used in-situ since the DYNM does not require stable boundary conditions. Furthermore, the procedure given in this paper could be used for relatively fast and inexpensive U-value approximation without the use of expensive equipment (e.g., heat flux sensors).
Detection Rate of 18F-Labeled PSMA PET/CT in Biochemical Recurrent Prostate Cancer: A Systematic Review and a Meta-Analysis
Authors: Treglia Giorgio , Annunziata Salvatore , Pizzuto Daniele A. , Giovanella Luca , Prior John O. , Ceriani Luca
Published: May 2019

Background: The use of radiolabeled prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) for biochemical recurrent prostate cancer (BRPCa) is increasing worldwide. Recently, 18F-labeled PSMA agents have become available. We performed a systematic review and meta-analysis regarding the detection rate (DR) of 18F-labeled PSMA PET/CT in BRPCa to provide evidence-based data in this setting. Methods: A comprehensive literature search of PubMed/MEDLINE, EMBASE, and Cochrane Library databases through 23 April 2019 was performed. Pooled DR was calculated on a per-patient basis, with pooled proportion and 95% confidence interval (95% CI). Furthermore, pooled DR of 18F-PSMA PET/CT using different cut-off values of prostate-specific antigen (PSA) was obtained. Results: Six articles (645 patients) were included in the meta-analysis. The pooled DR of 18F-labeled PSMA PET/CT in BRPCa was 81% (95% CI: 71–88%). The pooled DR was 86% for PSA ≥ 0.5 ng/mL (95% CI: 78–93%) and 49% for PSA < 0.5 ng/mL (95% CI: 23–74%). Statistical heterogeneity was found. Conclusions: 18F-labeled PSMA PET/CT demonstrated a good DR in BRPCa. DR of 18F-labeled PSMA PET/CT is related to PSA values with significant lower DR in patients with PSA < 0.5 ng/mL. Prospective multicentric trials are needed to confirm these findings.
Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy
Authors: Soundararajan Rama , Fradette Jared , Konen Jessica , Moulder Stacy , Zhang Xiang , Gibbons Don , Varadarajan Navin , Wistuba Ignacio , Tripathy Debasish , Bernatchez Chantale , Byers Lauren , Chang Jeffrey , Contreras Alejandro , Lim Bora , Parra Edwin , Roarty Emily , Wang Jing , Yang Fei , Barton Michelle , Rosen Jeffrey , Mani Sendurai
Published: May 2019

Over the last decade, both early diagnosis and targeted therapy have improved the survival rates of many cancer patients. Most recently, immunotherapy has revolutionized the treatment options for cancers such as melanoma. Unfortunately, a significant portion of cancers (including lung and breast cancers) do not respond to immunotherapy, and many of them develop resistance to chemotherapy. Molecular characterization of non-responsive cancers suggest that an embryonic program known as epithelial-mesenchymal transition (EMT), which is mostly latent in adults, can be activated under selective pressures, rendering these cancers resistant to chemo- and immunotherapies. EMT can also drive tumor metastases, which in turn also suppress the cancer-fighting activity of cytotoxic T cells that traffic into the tumor, causing immunotherapy to fail. In this review, we compare and contrast immunotherapy treatment options of non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC). We discuss why, despite breakthrough progress in immunotherapy, attaining predictable outcomes in the clinic is mostly an unsolved problem for these tumors. Although these two cancer types appear different based upon their tissues of origin and molecular classification, gene expression indicate that they possess many similarities. Patient tumors exhibit activation of EMT, and resulting stem cell properties in both these cancer types associate with metastasis and resistance to existing cancer therapies. In addition, the EMT transition in both these cancers plays a crucial role in immunosuppression, which exacerbates treatment resistance. To improve cancer-related survival we need to understand and circumvent, the mechanisms through which these tumors become therapy resistant. In this review, we discuss new information and complementary perspectives to inform combination treatment strategies to expand and improve the anti-tumor responses of currently available clinical immune checkpoint inhibitors.
ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer
Authors: Pandey Gaurav , Borcherding Nicholas , Kolb Ryan , Kluz Paige , Li Wei , Sugg Sonia , Zhang Jun , Lai Dazhi A. , Zhang Weizhou
Published: May 2019

Among all breast cancer types, basal-like breast cancer (BLBC) represents an aggressive subtype that lacks targeted therapy. We and others have found that receptor tyrosine kinase-like orphan receptor 1 (ROR1) is overexpressed in BLBC and other types of cancer and that ROR1 is significantly correlated with patient prognosis. In addition, using primary patient-derived xenografts (PDXs) and ROR1-knockout BLBC cells, we found that ROR1+ cells form tumors in immunodeficient mice. We developed an anti-ROR1 immunotoxin and found that targeting ROR1 significantly kills ROR1+ cancer cells and slows down tumor growth in ROR1+ xenografts. Our bioinformatics analysis revealed that ROR1 expression is commonly associated with the activation of FGFR-mediated signaling pathway. Further biochemical analysis confirmed that ROR1 stabilized FGFR expression at the posttranslational level by preventing its degradation. CRISPR/Cas9-mediated ROR1 knockout significantly reduced cancer cell invasion at cellular levels by lowering FGFR protein and consequent inactivation of AKT. Our results identified a novel signaling regulation from ROR1 to FGFR and further confirm that ROR1 is a potential therapeutic target for ROR1+ BLBC cells.