bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of Pancreatitis After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis
Authors: Magahis Patrick T. , Chhoda Ankit , Berzin Tyler M. , Farrell James J. , Wright Drew N. , Rizvi Anam , Hanscom Mark , Carr-Locke David L. , Sampath Kartik , Sharaiha Reem Z. , Mahadev SriHari
Published: July 2024

INTRODUCTION:

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is frequently used to risk-stratify pancreatic cystic lesions (PCLs). Rising PCL incidence and developments in tissue acquisition and specimen analysis necessitate updated appraisal of EUS-FNA safety, particularly the risk of postprocedure pancreatitis, the most common EUS-FNA-related adverse event. Our systematic review aims to accurately quantify the risk of EUS-FNA-related pancreatitis to best inform decisions regarding EUS-FNA's optimal role in PCL workup.

METHODS:

We performed systematic searches in 4 databases from inception to April 2024 for original English-language studies investigating EUS-FNA-related pancreatitis. We extracted data on demographics and EUS-FNA-related pancreatitis risk, severity, and risk factors. These were meta-analyzed through the DerSimonian Laird Method using a random-effects model. Meta-regression of pancreatitis risk was performed to delineate associations with clinical and procedural characteristics.

RESULTS:

Sixty-four studies comprised 8,086 patients and reported 110 EUS-FNA-related pancreatitis events. Pooled risk of EUS-FNA-related pancreatitis was 1.4% (95% confidence intervals, −0.8% to 3.5%; I
2 = 0.00), which was predominantly of mild severity (67%) and uniformly nonfatal. Pancreatitis risk lacked significant association with sample size, age, sex, cyst size, needle caliber, or passes, although we noted trends toward higher risk in studies published after 2015, those using higher gauge needles (19 G vs 22 G/25 G), and those performing EUS-guided through-the-needle biopsy.

DISCUSSION:

We note with high certainty that pancreatitis after EUS-FNA of PCLs is infrequent and mild in severity with no mortality in the included cohort. EUS-guided through-the-needle biopsy may serve as a significant risk factor for EUS-FNA-related pancreatitis risk; however, further studies are needed to delineate other predisposing characteristics.
The paradox of progress: How ‘disruptive,’ ‘dual-use,’ ‘democratized,’ and ‘diffused’ technologies shape terrorist innovation
Authors: Rassler Don , Veilleux-Lepage Yannick
Published: July 2024

Building upon the existing literature on terror innovation, this research article introduces a new analytical framework that highlights four key elements of emerging technologies which facilitate their adoption by terrorist groups. We posit that technologies that are inherently ‘disruptive,’ ‘dual-use,’ ‘democratized,’ and ‘diffused’ are particularly susceptible to misuse by terrorists, and that it is the interplay between these factors that helps to drive future directions of tech-enabled terror. We draw on terror and extremist interest in and use of two key technology areas – unmanned aerial systems and additive manufacturing, specifically 3‑D‑printed firearms – as examples to highlight how the factors in the framework interact and how they help to drive innovative terror behavior. We conclude with a series of concise recommendations to mitigate harmful terrorist use of these and other disruptive technologies and limit the impact of future tech-enabled terrorist innovations.
Perception of the risks inherent in new AI technologies
Authors: Machleidt Petr , Mráčková Jitka , Mráček Karel
Published: July 2024

Artificial intelligence (AI) has undergone rapid development and is becoming one of the major social issues. The advent of generative AI is not only associated with potential benefits but also poses a number of risks, such as increasing malicious misuse. This brings the issue of regulating new AI technologies into focus. In the search for solutions, the article revisits the problem of applying the precautionary principle. We critically evaluate regulatory approaches, particularly with regard to maintaining an innovation-friendly environment. A prudent approach to new AI technologies not only requires regulatory measures but also places new demands on the education system. We also discuss the regulation of AI from the perspective of Czech legislation in a broader international context. Current challenges in the field of AI competence are highlighted. To make the issue more tangible, we provide specific examples from the Czech Republic.
Instrumentos fiscales en España frente a la despoblación: la eficacia de los beneficios tributarios en el impulso demográfico de nuestro país
Authors: Soto Moya María del Mar
Published: July 2024

Este estudio aborda el reto actual de la despoblación y las posibles actuaciones que, en el ámbito del derecho financiero, pueden llevarse a cabo para la a implementación de medidas tributarias, incidiendo en la importancia de los beneficios fiscales como instrumento para hacer frente a la pérdida de población en determinadas zonas. El artículo analiza las medidas fiscales vigentes en el ámbito autonómico y también en el local, así como su idoneidad para conseguir atraer población a zonas o municipios en riesgo de despoblación.
La aplicación de la exención con progresividad para las pensiones públicas procedentes de Países Bajos. Análisis de la STS de 13 noviembre de 2023, Recurso Casación Núm. 5748/2022
Authors: Gómez Requena José Ángel
Published: July 2024

El presente trabajo analiza la sentencia de Tribunal Supremo, Sala Tercera, de 13 de noviembre de 2023, recurso de casación 5748/2022, referente a la aplicación de la exención con progresividad a las rentas consistentes en pensiones públicas procedentes de Países Bajos y que son percibidas por un residente fiscal en España. En concreto, la Sala de lo Contencioso- Administrativo determina que la Administración tributaria española puede aplicar directamente la exención con progresividad establecida en el Convenio fiscal entre España y Países Bajos en su art. 25.3 en virtud de la cobertura jurídica aportada por la D.A. 20ª Ley del IRPF. En este trabajo se estudia el alcance y efectos de esta doctrina, así como la conveniencia de que el legislador establezca una norma doméstica que detalle los supuestos en los que puede aplicarse la exención con progresividad cuando se declare en un CDI esta posibilidad.
Tax rulings y cláusulas nacionales antiabuso bajo el control de las Ayudas de Estado: cuando la autonomía de los estados miembros de la Unión Europea prevalece sobre la protección de la libre competencia. Análisis de la STJUE de 5 de diciembre de 2023, as
Authors: Ferreiro Serret Estela
Published: July 2024

Con la sentencia de 5 de diciembre de 2023, sobre los asuntos acumulados C-451/21 P y C-454/21 P, el TJUE ha vuelto a insistir en la necesidad de que la Comisión Europea, en el desarrollo del procedimiento de control de las ayudas de Estado, solamente tenga en cuenta el Derecho nacional aplicable en el Estado miembro e identifique operaciones comparables para determinar la existencia de una ventaja selectiva en el sentido del artículo 107.1 TFUE cuando la medida en cuestión quede fuera de los ámbitos en los que el Derecho tributario de la Unión Europea es objeto de armonización. En este caso, se trata de una doble no imposición nacional derivada de la combinación de diferentes operaciones intragrupo, validadas por varias decisiones fiscales anticipadas – tax rulings – adoptadas por la Administración tributaria luxemburguesa. El Tribunal, para resolver ambos asuntos acumulados, aplica la jurisprudencia anterior, pero aún reciente, sobre cómo determinar la existencia de una ventaja selectiva cuando existe una decisión fiscal anticipada, establecida en la STJUE de 8 de noviembre de 2022, asuntos acumulados C-885/19 P y C-898/19 P. Pero, además, por primera vez, el Tribunal establece los requisitos para que la no aplicación de una cláusula antiabuso nacional pueda otorgar una ventaja selectiva en el sentido del artículo 107.1 TFUE. Para ello, el TJUE aplica la misma doctrina adoptada para los tax rulings, exigiendo a la Comisión Europea la identificación de situaciones comparables y la demostración de que la Administración en cuestión se aparta de su práctica habitual.
Fruit extracts of various cornelian cherry (Cornus mas L.) cultivars as antioxidant therapy for alleviating nitrative stress in erythrocytes of blood in experimental diabetes mellitus
Authors: Brodyak I. V. , Moroz A. A. , Kucharska A. Z. , Sybirna N. O.
Published: July 2024

Natural antioxidants (vitamins, bioflavonoids, anthocyanins, etc.) are used to prevent the development of oxidative-nitrative stress in diabetes mellitus (DM), which helps to restore or avert functional disorders in the cells and tissues of the body.
The aim of the study is to investigate the effect of extracts of the fruit of different cultivars of the cornelian cherry, as well as their main iridoid glycoside – loganic acid, on the activity of NO-synthase and the content of stable metabolites of NO in blood erythrocytes of rats with streptozotocin-induced diabetes.
Materials and methods. In the work, we used the extract of the fruits of the cornelian cherry “Podolski” cultivar (BDPA 10462), the ripe fruits of which have a red color, and the extract of the “Yantarnyi” (BDPA 14131) and “Flava” (BDPA 8795) cultivars, the ripe fruits of which have a yellow color. Loganic acid was extracted from yellow fruits of the “Yantarnyi” and “Flava” cultivars of Cornus mas L. All studied extracts were administered to rats orally for 14 days from the 10th day after the induction of DM. The dose of administration was 20 mg/kg body weight.
Results. The extract of the red fruits is demonstrated the most pronounced effect in normalizing the biomarkers of nitrative stress (activity of NO-synthase and its isoforms, the content of nitrite and nitrate anions) in erythrocytes of rats with diabetes. The extract of the yellow fruits shows a positive effect on the suppression of nitrative stress, which has been indicated by a decrease in the activity of iNO-synthase to the values in the control group of animals. Loganic acid, on the contrary, inhibited the eNO-synthase. In addition, the extract of yellow fruits of cornelian cherry and loganic acid decreased the level of NO3– and increased the content of NO2– in erythrocytes of diabetic rats.
Conclusions. Biomarkers of nitrative stress in erythrocytes of rats with streptozotocin-induced diabetes indicated the antioxidant properties of fruit extracts of cornelian cherry, in particular the red fruits, which contain a large amount of anthocyanins.
Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
Authors: Shynchukovskyi I. A. , Tereshchuk O. H.
Published: July 2024

The prevalence of temporomandibular joint (TMJ) osteoarthritis is 18–85 % of all TMJ dysfunctional conditions. Most patients are elderly, especially women. Today, intra-articular injections are often used for treatment, so it is necessary to study the effectiveness of drug administration on the course of the disease. The number of studies on the effectiveness of certain drugs most commonly used to treat TMJ osteoarthritis is limited, that does not allow correct treatment planning in each individual case.
Aim: to evaluate the effectiveness of TMJ osteoarthritis treatment with monotherapy with hyaluronic acid, corticosteroids, and platelet-rich plasma.
Materials and methods. We included 90 patients who received intra-articular injections. Patients were randomly divided into 3 groups: group I, which received platelet-rich plasma (PRP, n = 30), group II, which received hyaluronic acid (HA, n = 30), group III, which received corticosteroids (CS, n = 30). To objectively evaluate the effectiveness of TMJ osteoarthritis treatment with monotherapy of hyaluronic acid, corticosteroids and platelet-rich plasma, the following indicators were used: filling in the visual analogue pain scale, maximum mouth opening (mm) and cortical plate density of the articular head of the mandible according to the Hounsfield scale using CBCT.
Results. PRP therapy demonstrated the highest efficacy in the form of monotherapy for all study parameters (p < 0.05). The fastest pain reduction was achieved with the use of corticosteroids (p < 0.05). In general, during the treatment period, the reduction of pain according to the visual analogue scale in group I was 85.71 %. In patients of group II (HA) and group III (CS) – by 71.42 %. Maximum mouth opening after treatment in group I increased by 24.32 %, in group II – by 15.79 %, in group III – by 18.92 %. The density of the articular head according to the Hounsfield scale after treatment in group I increased by 12.56 %, in group II – by 6.97 %, in group III – by 4.87 %.
Conclusions. All of the studied drugs demonstrated a positive effect on the treatment of TMJ osteoarthritis, but monotherapy with intra-articular PRP injections demonstrated the highest effectiveness according to the studied parameters (p < 0.05).
Structural and functional changes of the heart in patients with coronary heart disease who have had coronavirus disease COVID-19
Authors: Manuilov S. M. , Mykhailovska N. S.
Published: July 2024

The aim of the study: to investigate the effect of the previous COVID-19 coronavirus disease on the features of cardiac remodeling in patients with coronary heart disease (CHD).
Materials and methods. 71 patients with CHD were involved in the study: stable angina pectoris II–III FC (age 69.0 (64.0; 76.0) years): 1 group (main) – 31 patients with CHD in long COVID-19 period; group 2 (comparison) – 40 patients with CHD without a history of COVID-19. Features of cardiac remodeling and energy work of the left ventricular (LV) myocardium were assessed using the echocardiography method.
Results. CHD patients with a history of COVID-19 had greater changes in linear and volumetric parameters of the heart, an increase in the degree of hypertrophy of the LV myocardium, frequency of registration of LV diastolic dysfunction against the background of an increase in the mean pressure in the pulmonary artery, end-systolic pressure, decrease in global LV contractile function (LVF) compared to patients without COVID-19 history (p < 0.05). In CHD patients who suffered from COVID-19, there was an increase in the estimated energy expenditure of the LV myocardium: shock work by 14.77 % (U = 461.5; p < 0.05), potential energy by 34.68 % (U = 316.5; p < 0.05) and the pressure-volume zone by 17.78 % (U = 373.0; p < 0.05), which indicates a decrease in the speed of myocardial recovery in long COVID period. It was established that the presence of COVID-19 in the history of patients with CHD is associated with an increased risk of LV dilatation by 5.6 times (95 % CI 1.71–18.29; p < 0.05), LV myocardial hypertrophy by 3.05 times (95 % CI 1.79–5.91; p < 0.05), LV diastolic dysfunction by 1.44 times (95 % CI 0.91–2.29; p < 0.05), an increase in energy expenditure during heart work by 1.66 times (95 % CI 0.68–4.02; p < 0.05).
Conclusions. Patients with coronary heart disease have more significant structural and functional changes and energy expenditure during the work of the heart, which proves the negative impact of SARS-CoV-2 on the state of cardiac remodeling in patients with CHD in long COVID-19 period.
Ramification of Hall effects in a non-Newtonian model past an inclined microchannel with slip and convective boundary conditions
Authors: Roja Ajjanna , Saadeh Rania , Kumar Raman , Qazza Ahmad , Khan Umair , Ishak Anuar , Sherif El-Sayed M. , Pop Ioan
Published: July 2024

Many applications, including micro air vehicles, automotive, aerospace, refrigeration, mechanical–electromechanical systems, electronic device cooling, and micro heat exchanger systems, can be used to determine the heat flow in microchannels. Regarding engineering applications, heat flow optimization discusses the role of entropy production minimization. Therefore, this work explores new facets of entropy production in fully developed Carreau fluid heat transport in an inclined microchannel considering exponential space/temperature dependence, radiative heat flux, and Joule heating. The Carreau fluid model’s rheological properties are taken into account. Additionally, the influence of Hall slip velocity and convective boundary conditions is considered. Using appropriate transformation constraints, the governing equations are transformed into a system of ordinary differential equations, which are then numerically solved using the fourth- and fifth-order Runge–Kutta–Fehlberg method. Graphs illustrate a significant discussion of physical parameters on production of entropy, Bejan number, thermal field, and velocity. Our findings established that there is a dual impact of entropy generation for the exponential space/temperature-dependent, radiation parameter, Hall parameter, Weissenberg number, and velocity slip parameter. The Bejan number decreased with the Hall current and the Weissenberg number, and it enhanced with exponential space/temperature dependent. The convection constraint maximizes the entropy at the channel walls. The results are compared with exact solutions, which show excellent agreement.
Green hydrogen production in Uruguay: a techno-economic approach
Authors: Bouzas Betiana , Teliz Erika , Díaz Verónica
Published: July 2024

In 2015, the participants of the Paris Agreement collectively acknowledged the urgent need for immediate actions to decarbonize their national economies, with the aim of mitigating the adverse impacts of climate change. There is a call for policymakers to step up efforts to significantly reduce greenhouse gas (GHG) emissions in all economic sectors, with a focus on prioritizing options that can deliver substantial emission cuts. Some industry and transport subsectors present significant challenges in terms of technical and economic feasibility. Viable solutions for these sectors, known as “hard-to-abate” sectors, are limited. Green hydrogen has emerged as a promising alternative that is gaining increasing attention. It is poised to play a crucial role in transitioning towards a more sustainable future. There is a growing interest in green hydrogen among researchers, institutions, and nations, all committed to advancing its development, improving efficiency, and reducing costs. This paper explores the concept of green hydrogen, particularly its production processes that rely on renewable energy sources in Uruguay. It demonstrates the significant potential for green hydrogen production, facilitating the transition from fossil fuels to clean energy and promoting environmental sustainability through the widely accepted electrolysis process. Uruguay currently boasts a high percentage of renewable electricity generation (reaching 97 % in 2020). To support this further, there is a need to increase renewable energy capacity, which would impact the energy prices. The cost of energy accounts for more than 40 % of the levelized cost of hydrogen (LCOH) in all studied scenarios. Additionally, optimizing the costs associated with electrolysers, which can exceed 30 % of the LCOH in polymer electrolyte membrane (PEM) electrolysis, is crucial. This optimization is essential for positioning the country as a net exporter of green hydrogen. The range of LCOH values calculated in the different scenarios is between 2.11 USD/kg H2 and 4.12 USD/kg H2. According to updated specialized literature, achieving LCOH values under USD 1.4/kg H2 is essential for this goal.
Commodity Price and Indonesian Fiscal Policy: An SVAR Analysis with Non-Gaussian Errors
Authors: Mansur Alfan
Published: July 2024

This study exploits the non-Gaussianity for identification of a Bayesian SVAR model on newly unexplored monthly Indonesian data from 2007M1–2022M12, where we disentangle the commodity-related revenue from the total government revenues. Our main contribution is in labeling the statistically identified structural shocks as economic shocks by conducting a formal assessment of a set of proposed sign constraints. We simultaneously label a commodity price and three fiscal policy shocks, i.e. fiscal income tax, investment-spending, and consumption-spending shocks. Having evaluated their impacts, among the fiscal policy shocks, we find income tax shock the most impactful on output. Moreover, during the Covid crisis 2020–2021, the launched fiscal economic stimulus package (PEN program) positively contributed to the output. The recession of the Covid crisis could have deepened had the fiscal policymaker not responded at all. Albeit so, we should not overlook the contribution of the rising commodity prices to the output recovery. We also evaluate the commodity boom period in 2007–2009, the tax amnesty program in 2016–2017 and 2022, and the infrastructure spending boost in 2015. Our results suggest that output and retail sales would have been lower without the commodity price shock’s contribution during the commodity boom. Then, we find that tax amnesty and infrastructure spending boost policies contribute to higher retail sales.
Request for confirmation sequences in Mandarin Chinese
Authors: Li Xiaoting
Published: July 2024

As a social action, requesting confirmation involves presenting a proposition to be (dis)confirmed and seeking another’s (dis)confirmation of the proposition. This article provides an overview of the lexico-syntactic and prosodic resources used by participants to perform requests for confirmation (RfCs) and to respond to RfCs in Mandarin face-to-face interactions. Drawing on statistical results of the frequencies of a variety of linguistic resources in RfC sequences, this study shows that declaratives are the most frequently used syntactic forms for RfCs in the Mandarin data. Tags, such as shiba ‘right?’, are also frequently used by the speaker to seek (dis)confirmation from the recipient. The RfCs in the data also exhibit one prominent prosodic pattern. That is, a larger number of RfC turns in Mandarin end with falling pitch movement with very moderate slope from mid (M) to low (L). This prosodic pattern stems from the interplay between tones and intonation in Mandarin. In the responses to RfCs, a majority of them are confirmations. Also, response tokens, such as dui ‘right’ and en ‘en’ with falling intonation, are used highly frequently in responses to RfCs in the Mandarin data. Findings in this study afford cross-linguistic research on RfC sequences.
“Separated, but far from alone”
Authors: Blevins Cameron , Heinz Annelise
Published: July 2024

Our article examines how women built an expansive community during the 1970s and 1980s through the pages of Lesbian Connection, one of the era’s most widely circulated publications of the lesbian feminist movement. To reveal this community, we map thousands of locations that appeared in the periodical, revealing a geography that tilted toward rural areas and mid-sized cities instead of the major metropolitan centers that have received much of the attention within LGBTQ scholarship. Through the magazine’s reader-submitted content, advertisements for lesbian-owned businesses, and a directory of volunteers who served as local contacts for an area, Lesbian Connection bridged the spatial scales of long-distance media networks and in-person interactions to create a vibrant lesbian community that transcended region and locality.
Bosančica (zapadna ćirilica) kroz odabrana krajišnička pisma
Authors: Midžić Fikret
Published: July 2024

Bosančica (Western Cyrillic) through the selected border’s (krajišnik’s) letters The importance of the written word is immutable to humanity because it was the main driver and keeper of every culture. In this context, the paper also looks at letters that, upon the arrival of Ottoman authorities, were accepted as such as a means of communication between the Captain of Krajina and other Ottoman generals with Croatian officers and authorities ‘on one side of the border’;. They are written mostly in one type of Bosniancyrillic, mostly with an icicle, and only with some eyebrows. In these letters that we call the ‘signatures’, we see the respect of the culture of the recipients expressed through a properly measured amount of localizations, turks and other so-called. a stranger, who witnesses not only national, but also religious tolerance. These numerous letters in use from the 15th to the middle of the 19th century have great value for studying history, cultural heritage, politics and social and economic history. The author illustrated his conclusion with four such letters from the 18th century.
Preliminarni rezultati arheoloških istraživanja palasa Starog grada Sokolca u Brinju
Authors: Azinović Bebek Ana , Janeš Andrej
Published: July 2024

On the hillside in the middle of the Brinje field is the Old Town, known as Sokolac. The medieval fortress was built in the 13th century, and its present feature dates back to the beginning of the 15th century. It consists of an irregular oval core arranged around the rectangular yard. The remains of the entrance tower are on the west side, while the eastern one is defined by a multi-storey building with a chapel. On the south side, there is a massive roundel. The whole hillside was surrounded by a defensive wall fortified by semicircular towers and a square entrance tower. It was built by the princes of Krčki who held it until the first half of the 16th century when the Military Frontier took over the fortress management. When the army left this area, the fortress was left to decay. This article presents the preliminary results of archaeological research conducted since 2014. Researches have contributed to new cognitions about the time of the fortress construction, as well as its development phases. This research activities have found the remains of a prehistoric settlement dating back to the late Bronze Age and Iron Age. Today's visible fortress was preceded by a rectangular object from 12th or 13th century. At the end of the 14th century, the fortress slowly takes on the visible contours and at the beginning of the 15th century, an object with a substructure and a chapel was built on the east side. In 1530, the Imperail Army took over the authority of the fortress and modifies the eastern side and built an outer defensive ring with semi-towers and bastions.
Grbovi knezova Krčkih i Kurjakovića Krbavskih u kaštelu Grobnik
Authors: Sulejmanagić Amer
Published: July 2024

U radu se analiziraju heraldičke predstave na kruni cisterne u kaštelu Grobnik. Sama kruna cisterne je odavno poznata znanstvenoj javnosti, ali njezina heraldika, iako primarni izvor, nije do sada bila predmetom posebnih istraživanja. Poslije detektiranja nositelja grbova onom rodu knezova Krčkih dat je razvoj heraldike i djelomične primjene, a u slučaju grba Kurjakovića Krbavskih istraživanje je fokusirano na baziliske (zmajeve). Analizirani su mogući utjecaji i povodi za usvajanje baziliska (zmajeva) u heraldiku roda te je zaključeno kako se ne radi o prikazivanju Reda Zmaja kralja Sigismunda. Bazilisk koji proždire čovjeka jasno upućuje na utjecaj Milana i vezu s vladarem iz kuće Sforza pa je utvrđeno da se radi o grbu krbavske kneginje Doroteje, a nositelj drugog grba je vjerojatno njezin brat Bernardin Frankapan.
Promišljanja o globalnim promjenama u odgoju i obrazovanju i očuvanju baštine
Authors: Franić Šimunić Marina
Published: July 2024

Zbornik radova Globalne promjene u obrazovanju i očuvanje baštineUredništvo: Anela Nikčević-Milković, Jasminka Brala-Mudrovčić, Denis JurkovićSveučilište u ZadruZadar, 2023., 306 str.
Composite detergents with antibacterial properties based on mixtures of cetylpyridinium chloride with Genapol
Authors: Ospanova Zhanar , Bayanova Emine , Askarova Dana , Amankeldi Fariza , Nikulina Elena
Published: July 2024

This study focuses on the properties of the nonionic surfactant Genapol and the cationic surfactant cetylpyridinium chloride (CPC) to develop a composite detergent with bactericidal activity. Research includes studying the properties of CPC and Genapol solutions, creating composite mixtures with different concentration ratios and assessing the bactericidal effectiveness of the resulting detergents.
The main foaming agents CPC and Genapol were used without purification, which emphasizes their high biodegradability. Various tests, including surface tension measurements, contact angle evaluation and pH measurements, were carried out at room temperature to evaluate the properties of surfactants and surfactant mixtures.
The results show that CPC exhibits foaming, emulsifying and bactericidal properties due to its high surface activity and adsorption capacity. Genapol has the advantages of high surface activity at different pH levels, excellent foaming and emulsifying properties. The combination of these surfactants in a complex detergent creates a universal cleaner with antibacterial properties independent of pH and environmental harshness. The bactericidal effect of solutions of CPC Genapol mixtures was also determined.
The results show that the composite solution exhibits a noticeable bactericidal effect with zones of growth inhibition ranging from 13.5±0.5 mm to 17±0.1 mm. The greatest antibacterial activity was observed against Micobacterium citreum and Bacillus subtilis. Sarcina flava and Staphylococcus aureus showed similar growth inhibition results.
Synthesis and optical properties of fluorene-azulene π-conjugated polymers
Authors: Merhatuly Nurlan , Iskanderov Ablaykhan , Abeuova Saltanat , Iskanderov Amantay , Zhokizhanova Saltanat , Erniyazova Bibizhan
Published: July 2024

The non-alternant aromatic hydrocarbon azulene as a potential building block for the creation of new polymer conjugated materials is attracting more and more attention due to its unique chemical structure, optical and physico-chemical properties. The azulene conjugated polymers were synthesized by the interaction of 1,3-dibromoazulene or 2,7-bis(3-bromoazulene1-yl)-9,9-dihexyl-9H-fluorene with 2,2’-(9,9-dihexylfluorene-2,7-diyl)bis(1,3,2-dioxaborolan) under the conditions of the Suzuki cross-coupling reaction: poly[2,7-(9,9-dihexylfluorenyl)- alt-(1ꞌ,3ꞌ-azulenyl)] 3 and poly[1,3-bis(9ꞌ,9ꞌ-dihexylfluorene-2ꞌ-yl)azulenyl]-alt-[1ꞌꞌ,3ꞌꞌ-azulenyl] 5. The photophysical and thermal properties of the obtained fluorene-azulene polymers were characterized by UF-Vis and fluorescence spectroscopy, as well as methods of thermogravimetric analysis and differential scanning calorimetry. It was found that polymers 3 and 5 do not emit in a neutral state in various organic solvents. However, they become fluorescent on treatment with trifluoroacetic acid in tetrahydrofuran. The “activation” of fluorescence in protonated azulene copolymers 3-H+ and 5-H+ occurs due to the formation of the 6π-electron aromatic azulene cation, which changes the overall electronic character, in particular, the levels of the frontal molecular orbitals of the HOMO and LUMO, and then the band gap. The obtained results demonstrate that the inclusion of azulene structural units in the conjugated polymer strucrure has great potential for the development of new protonic organic functional materials.
New zircon-manganites of lanthanum and alkali metals
Authors: Turdiyev Myktybek , Kasenov Bulat , Nukhuly Altynbek , Stoev Mitko , Sagintaeva Zhenisgul , Kasenova Shuga , Kuanyshbekov Erbolat
Published: July 2024

Zircon-manganites of the composition LaMeI2ZrMnO6 (MeI – Li, Na, K). were synthesized using the ceramic technology method in the range of 800-1200°C by the interaction of lanthanum (III) oxides and lithium, sodium and potassium carbonates (analytical grade). Using X-ray diffraction methods, it was established that all synthesized zircon-manganites crystallize in a cubic system with the following lattice parameters: LaLi2ZrMnO6 – а = 16,26 ±0,02 Å; V0 = 4300,93 ±0,06 Å3; Z = 6; V° elem cell = 716,82 ± 0,02 Å3; r x-ray. = 5,49 g/сm3; r picn. = 5,42 ± 0,06 g/сm3; LaNa2ZrMnO6 – а = 16,85 ± 0,02Å; V0 = 4785,46 ± 0,02 Å3; Z = 6; V° elem cell = 795,58 ± 0,02 Å3; r x-ray. = 5,35 g/сm 3; r picn. = 5,30 ± 0,04 g/сm 3; LaK2ZrMnO6 – а = 17,45 ± 0,03 Å; V0 = 5318,85 ±0,09 Å3; Z = 6; V° elem cell = 885,81 ± 0,02 Å3; r x-ray. = 5,16 g/сm 3; r picn. = 5,08 ± 0,02 g/сm 3. It has been established that with an increase in ionic radii in the Li®Na®K series, the values of the parameter “a” and the volumes of lattices and unit cells of zircon-manganites increase.
El individualismo y la meritocracia como instrumentos de "disciplinamiento" y "normalización" de las personas dentro de las actuales sociedades de mercado
Authors: Zambrano Sanjuán Carlos Andrés
Published: July 2024

Frente a la actual crisis de la democracia que afecta a múltiples sociedades occidentales, producto en gran medida del descontento social originado en la desigualdad que caracteriza a estas denominadas sociedades neoliberales de mercado y de consumo, el presente ensayo explora la hipótesis de que dicho resentimiento social y la crisis institucional aludida obedecen a dos instrumentos implantados por las élites con el fin no sólo de asegurar y perpetuar sus privilegios sino, más importante, para ejercer el control y la disciplinación de la sociedad mediante: el rompimiento de los lazos comunitarios, por medio del individualismo y el consumismo extremos (1); y de la internalización del fracaso y la justificación de la desigualdad, a través de la meritocracia (2).
Modalidades y tecnologías de enseñanza en la educación superior: ejercicio cienciométrico y de minería de texto
Authors: Idárraga-Ortiz Sergio Alejandro , Cervantes Díaz Martha , Vargas Leal Viviana Marcela
Published: July 2024

En la actualidad, las Instituciones de Educación Superior (IES) asumen un importante reto en relación con los Objetivos de Desarrollo Sostenible, en especial con relación al objetivo 4 denominado Educación de Calidad; para que la oferta educativa de las IES sea oportuna y responda a las necesidades del entorno es necesario adoptar las nuevas modalidades de enseñanza-aprendizaje y las nuevas tecnologías que impulsen una reforma educativa que propenda por la promoción del conocimiento en las nuevas realidades. En Colombia, las instituciones de educación superior compiten con la oferta nacional e internacional, por ello es crucial identificar las tendencias educativas y los referentes en modalidades de formación y métodos de enseñanza en la Educación superior, para ello se desarrolló un ejercicio de vigilancia tecnológica con aplicación de análisis bibliométrico y minería de textos que arrojó los siguientes resultados: se puede observar una tendencia creciente en la divulgación de los trabajos de investigación, en los que 2020 y 2021 son los años de mayor actividad científica, coincidiendo estos con la pandemia del COVID-19, la tasa de crecimiento anual (2010 -2022) fue de 23,35% con un R² = 0,9912; la mayoría de las publicaciones se ubican en las Ciencias sociales (32%), seguido por las Ciencias computacionales (29%), ingeniería (12%), medicina (5%) y matemáticas (4%); los países líderes en esta producción son Estados Unidos produjo 3413 (15,07%), seguido por el Reino Unido con 1894 (8,36%), España con 1762 (7,78%) y China con 1567 (6,92%), a nivel latinoamericano, Brasil aportó 471 (2,08%) documentos, seguido por México con 310 (1,37%), Colombia con 194 (0,86%), Ecuador con 156 (0,69%); del análisis de términos clave se resaltan el e-learning y online learning como las modalidades con mayor abordaje por parte de los investigadores. Por otra parte, a partir de la identificación de la oferta de la Universidad Santo Tomás seccional Bucaramanga se realizaron análisis cienciométricos específicos para las áreas de conocimiento relacionadas con cada división académica, con lo cual se identificaron las instituciones líderes en innovación educativa a nivel global y de Latinoamérica. Finalmente se realizó una revisión de las tendencias en metodologías de enseñanza y aprendizaje de las que se destacan con mayor interés la implementación de e-learning, metodologías híbridas con presencialidad flexible, la formación a través de microcredenciales y la necesidad de adoptar las tecnologías de la educación 4.0, tales como el Big data, la inteligencia artificial, la robótica y el Internet de las Cosas (IoT).
Variables de la condición física, predictores de los niveles de fragilidad en adultos mayores entre 60 y 64 años de Sabaneta, Antioquia
Authors: García Jose Javier , Vidarte Claros Jose Armando , Montoya Vega Juan Pablo , Arango Arenas Alejandro , Morera Salazar Didier Andres
Published: July 2024

Introduction: The study examines the prevalence and factors associated with frailty in older adults, highlighting the scarcity of research in Latin America and the need for a comprehensive healthcare approach to address this growing epidemiological concern. Purpose: The aim of this cross-sectional correlational descriptive study with a multivariate phase was to determine the physical fitness variables that predict frailty in older adults aged 60-64 years. It was conducted in Sabaneta, Antioquia during the first semester of 2021 with 125 healthy individuals aged 60-64 years. Methodology: For the qualitative variables, sex and frailty were statistically significantly related. For the quantitative variables, "leg strength", "right and left arm strength", "walking agility", and "aerobic walking endurance" were significant in relation to frailty. Results: In the linear regression model, it was found that the variable "walking agility" was the predictor of frailty in older adults. Prevalence of frail conditions in 85.6% of the cases, of which 48% had pre-frail conditions. Variables such as arm strength, leg strength, walking agility, and aerobic walking endurance were statistically significant. Conclusions: Walking agility is a predictive risk factor for frailty in older adults. Individuals with decreased walking agility have a 26% higher probability of being frail.
Holy See vision of the global legal and political order and its critical analysis
Authors: Rudinskas Aurimas
Published: July 2024

As the influence of the Holy See in the international arena increases due to the ongoing transformation of international society, resulting from the increasing influence of nongovernmental organizations and other non-state actors, it becomes important to know what legal and political mechanisms operating on a global scale, the Holy See proposes to solve the most pressing problems of humanity. It was found that between 1939 and 1956 the Holy See proposed the idea of an international legal peace institution and publicly supported the idea of a world government or world federation promoted by the World Federalist Movement. Both must ensure global security and peace. Since 1963 until 2015 the Holy See promoted the idea of a world political authority with the power, institution and means to effectively solve global problems. The research shows that these projects contain features of social contract theory. The reform of the United Nations organization, giving it more powers, is considered the first step towards the emergence of a global public authority.
The N-(2,4-diarylthiazol-5-yl)benzamidines library creation and the effect of this compounds on cancer cell growth
Authors: Severin Oleksandr O. , Kachaeva Maryna V. , Pilyo Stepan G. , Shablykina Olga V. , Moskvina Viktoriia S. , Brovarets Volodymyr S.
Published: July 2024

A versatile and efficient protocol for the synthesis of library of N-(2,4-diarylthiazol-5-yl)benzamidines is described. We obtained a library of 25 diversity with different of substituents in four positions in key framework. The synthesized amidine derivatives were evaluated for their in vitro anticancer activity. Analysis of anticancer activity on 60 cancer cell lines showed a decrease of proliferation of Colon Cancer and Leukemia cell lines by more than half and allowed to establish the structure-activity relationship
Prospects of Interdisciplinary Research into the Problem of Resource Mobilization of Academic Staff
Authors: Zborovsky Garold E. , Ambarova Polina A.
Published: July 2024

Introduction. Mobilization of the resource potential of academic staff is a key task of university management. The development of management approaches to its solution should be preceded by a comprehensive study of both the academic staff resources and management practices. The possibilities of research are provided by an interdisciplinary theoretical and methodological framework. The purpose of the article is to substantiate the possibilities of developing interdisciplinary foundations for the study of the mobilization of the academic staff resource potential and the prospects for empirical study.
Materials and Methods. The theoretico-methodological nature of the article required the use of methods for generalizing and systematizing the provisions of interdisciplinary and disciplinary approaches and theories that have been developed by social and humanitarian science. The main directions for the exploration of the problem of academic staff resource potential in modern socio-humanitarian knowledge have been identified through the method of systematic analysis of literature.
Results. The main result of the research is the substantiation of the theoretical and methodological framework for an interdisciplinary study of the mobilization of the academic staff resources. This justification is based on the “revision” of theoretical and methodological provisions of theories of education. The basic interdisciplinary theories are the theories of adult continuing education, professional development and education, non-cognitive human capital, social networks, scientific and educational knowledge. Community-based, resource-based, institutional, normative, and communicative approaches are in demand. The provisions of these theories and approaches are adapted to the subject of the study. An important result of the research is the substantiation of the interdisciplinary synthesis in the practices of university management.
Discussion and Conclusion. The prospects for using the interdisciplinary framework in an empirical study dealing with evaluation and activation of academic staff resources are shown. The practical significance of the results lies in the development of a model of mobilization management of the academic staff resources.
Trudne decyzje terapeutyczne u wcześniaka ze skrajną hipotrofią, złożoną wadą serca i wrodzoną cytomegalią. Opis przypadku
Authors: Popczyńska Justyna , Flisek Dominika , Borek-Dzięcioł Beata , Orzeł Maria Marta , Kociszewska-Najman Bożena
Published: July 2024

Wrodzona cytomegalia to najczęstsze wirusowe zakażenie noworodków. Jej wczesne leczenie jest korzystne dla neurorozwoju dziecka. Wrodzone wady serca prowadzą do poważnych powikłań sercowo-naczyniowych. Celem pracy jest przedstawienie trudności w podejmowaniu decyzji terapeutycznych przy współistnieniu cytomegalii z wadą serca u wcześniaka ze skrajnie niską masą ciała. Przedstawiono przypadek dziewczynki urodzonej w 34. tygodniu ciąży bliźniaczej, z masą ciała 750 g, wrodzoną cytomegalią, dwuujściową prawą komorą, zwężeniem cieśni aorty, hipoplazją łuku. Ze względu na masę ciała i złożoność wady wykluczono zabieg kardiochirurgiczny do czasu osiągnięcia masy ciała 2000 g. Przyjęto postawę wyczekującą, z leczeniem zachowawczym. W związku z niepewnym rokowaniem i działaniami niepożądanymi gancyklowiru pojawiły się wątpliwości co do zasadności leczenia cytomegalii. Ostatecznie włączono gancyklowir w 20. dobie życia, a w 106. dobie wykonano operację bandingu tętnicy płucnej i rekonstrukcji łuku aorty, która przebiegła bez powikłań. Przy podejmowaniu decyzji terapeutycznych niezwykle istotne jest oszacowanie równowagi między ryzykiem oczekiwania na operację a ryzykiem samej operacji.
Possibility assessment for using protective coatings and polymer materials on tubing to prevent inorganic scaling on the inner surface of pipes
Authors: Berkov Denis V. , Kostyuk Ivan I. , Yudin Pavel E. , Verevkin Alexander G.
Published: July 2024

The inorganic scaling in wells is a common problem faced by mining companies. At present, the use of protective coatings for tubing as a measure to prevent or reduce the formation of inorganic scale deposits on pipe walls has not been fully studied. To use protective coatings as a measure to counteract the deposition of inorganic salts, it is necessary to develop a method that allows assessing the ability of coatings, as well as polymer and metal materials, to prevent the formation of inorganic scale deposits on the inner surface of pipes.

The article proposes a method for assessing the ability of protective coatings to resist the inorganic scaling on the inner surface of tubing. The proposed assessment method allows to make an informed decision on the advisability of using internal protective coatings of tubing to prevent (or reduce) the formation of inorganic scale deposits. The authors consider design features of a test bench for assessing the resistance of coatings to inorganic scale deposits, which allows to simulate the conditions for the formation of scale deposits that are as close as possible to the real conditions of oil production facilities. The article presents the results of bench tests of nine coating samples, two polymer samples and one sample made of St 40G2 steel. To assess the effectiveness of using tubing with an internal anti-corrosion coating as a measure to combat scale deposits, additional research is required to assess the possibility of complex use of coatings in conjunction with other methods of preventing processes of inorganic scaling. Thus, the authors developed the Bench for assessing the resistance of protective coatings of tubing to inorganic scale deposits. A dynamic testing technique is proposed to evaluate the resistance of protective coatings to inorganic scale deposits. Based on the presented results, conclusions were drawn about the possibility of using protective coatings on tubing as a measure to prevent the formation of inorganic scale deposits on the inner surface of the tubing.
Algunas calas en la poesía de protesta de un Parnaso sefardí: el cancionero AD-XI-57 de la Biblioteca Braidense de Milán
Authors: Nider Valentina
Published: July 2024

El cancionero AD-XI-57 de la Biblioteca Braidense, del último cuarto del siglo XVII, destaca por la variedad de los temas de los poemas incluidos y por la presencia de textos de famosos poetas españoles (Villamediana, Góngora, Quevedo) y, juntamente, de poetas conversos o nuevojudíos como Miguel de Barrios, Jacob de Pina, David Henríquez, Penso de la Vega etc. En este trabajo presentamos, en tres apartados, unos poemas de Alonso Álvarez de Soria y Cristóbal Flores, Antonio Raposo, Jacob de Pina y Manuel Gil de Viseu, ofreciendo las variantes con los demás testimonios conocidos y su contexto histórico literario.
Piezas de títulos de comedias. Tres nuevos textos de la sátira a la hagiografía. (Quinta entrega)
Authors: Arellano Ignacio
Published: July 2024

Se traza el estado de la cuestión hasta la fecha de los textos «de títulos de comedias», que fueron una moda en el siglo XVII y comienzos del XVIII, y se publican tres piezas inéditas conservadas en distintos manuscritos de la Biblioteca Nacional de España.
La sátira de la lealtad y el vasallaje: El «Quijote» de Cervantes y «El Buscón» de Quevedo
Authors: Strosetzki Christoph
Published: July 2024

En este artículo, en primer lugar se comentarán algunos textos, pertenecientes a la Edad Media y al Siglo de Oro, relacionados con la lealtad y el vasallaje. A continuación, se señalarán los límites de la lealtad en el Quijote. En tercer lugar, se indagará en la valoración que Quevedo hace del vasallaje y la lealtad. En sus escritos teóricos elogia repetidamente a los consejeros leales, a los ministros y a los favoritos, y reprende a los malos servidores, pide como estoico la supresión de afectos como la codicia, critica la estupidez y vanidad humanas, y en su obra Cómo ha de ser el privado recopila todas las buenas cualidades necesarias en esta figura política. Sin embargo, en El Buscón Quevedo muestra exactamente lo contrario.