bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case of Lymphoplasmacytic Cell Lymphoma Characterized by Marked Nuclear Fission and Brain Gyrus Nuclei of Lymphocytes
Authors:   Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China., Yang Zailin , Peng Yu ,   Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China., Ran Longrong ,   Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China., Wu Xuelian ,   Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China., Chen Shuang ,   Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
Published: May 2024

A 67-year-old male was admitted to the hospital due to fatigue and thrombocytopenia. Peripheral blood cells analysis showed the white blood cells count of 2.99 × 109 /L, red blood cell (RBC) count of 2.08 × 1012/L, platelet count of 15 × 109 /L. β2- microglobulin of serum was 5.50 mg/L. Whole-body positron emission tomography-computed tomography suggested altered reactivity in the lymph nodes of the bilateral neck. Morphological examination of bone marrow (BM) indicated the presence of abnormal smaller lymphocytes, accounting for 12.5% of the total nucleated cells. Strikingly, nuclear fission or brain gyrus nuclei were prominently observed in all abnormal lymphocytes (Figure 1, original magnification 1000×; Wright–Giemsa stain). The proportion of plasma cells was 0.5%, and no morphological abnormalities were observed. Additionally, some RBCs were exhibited a rouleaux arrangement. Flow cytometry analysis of BM identified 16.12% of κ-restricted B lymphocytes expressing CD5- , CD10- , CD19+ , CD20+ . A minimal proportion of 0.03% plasma cells with κ/λ ratio of 1.07. Consistent results were confirmed by immunohistochemistry in the BM biopsy. Immunofixation electrophoresis revealed abnormal monoclonal bands in the IgM and κ lanes. Furthermore, mutations of MYD88 (L265P), CXCR4 (T318fs), and TP53 (R306X) were identified through next-generation sequencing analysis. A diagnosis of lymphoplasmic cell lymphoma/waldenström macroglobulinemia (LPL/WM) was established.
Αnxiety, Depression and Stress in People Undergoing Surgery
Authors:   1st Propaedeutic Surgery Department, AHEPA University Hospital of Thessaloniki, Greece., Antonios Theofilidis , Daniel Paramythiotis ,   1st Propaedeutic Surgery Department, AHEPA University Hospital of Thessaloniki, Greece., Antonios Michalopoulos ,   1st Propaedeutic Surgery Department, AHEPA University Hospital of Thessaloniki, Greece.
Published: May 2024

The burden of negative emotional states, such as anxiety and depression and stress in people undergoing surgery it is indisputable, because it is a critical event that often happens perceived as an unfamiliar and frightening experience. Nursing also independently from the disease, often causes anxiety in many patients, who are going to be operated on. If constant and prolonged stress is not diagnosed early, can harm the patient and delay his recovery [1]. Perioperative anxiety is a significantly aggravating factor against the preparation of patients before a surgical operation. All are influenced by individual differences and its characteristics personality of each person, such as: Age, nutritional status, chronic conditions diseases or disabilities, surgical procedure (location, type and extent; surgery), as well as previous surgical experiences.
The Relationship between COVID-19 Infection and Breastfeeding: A Randomized Trial
Authors:   Doctoral School in Translational Medicine, San Pablo CEU University, Madrid, Spain., López García Eva Pilar
Published: May 2024

Problem: Currently in the world, 41.0% of children under 6 months are exclusively breastfed. Background: The COVID-19 pandemic has had a major impact on lactation. Question, hypothesis or aim: The COVID-19 virus alters the values of prolactin in maternal blood and is correlative with the establishment of lactation in a non-existent way. Methods: A statistical analysis of linear regression, prolactin analysis in the 3rd trimester of pregnancy and 15 days after delivery was performed in women with Covid-19 infection and healthy, finally the rates of breastfeeding were evaluated. The sample was made up of 680 pregnant women from central region of Spain.
Gender Features of Attitude to Cardiovascular Prevention in the Open Population of a Medium Urbanized Siberian City
Authors:   Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia., MI Bessonova , VV Gafarov ,   Institute of Therapy and Preventive Medicine-branch of the Federal State Budget Scientific Institution “Federal Research Center of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences” Novosibirsk, Russia., EV Akimova ,   Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia.
Published: May 2024

Relevance: According to the data of domestic and foreign epidemiological studies, the subjective-objective indicator of health, and in particular, the attitude of the population to the prevention and treatment of cardiovascular diseases, is the most important parameter characterizing the characteristics of the population’s motivation to maintaining public health. Purpose: To establish gender differences in the parameters of the subjective-objective indicator of health in the open urban population of 25-64 years old-attitudes towards the prevention of cardiovascular diseases.
Study on the anti–inflammatory effect of 3–(4–hydroxyphenyl) propionic acid in an in vitro LPS–stimulated acute kidney inflammation model
Authors: Kucukgul Altug , Nita Elif Ozturk
Published: May 2024

Acute kidney injury (AKI) is a syndrome defined by a rapid decrease in glomerular filtration that can be caused by sepsis, ischemia/reperfusion injury (IRI), or nephrotoxic drugs. Human microbiota makes significant contributions to human health by enzymatic transformation of such active substances and the release of molecules such as 3–4 hydroxyphenyl propionic acid (4–HPPA). Biological effects of 4–HPPA such as anti–inflammatory and antioxidant have been reported in many studies. The aim of the research is to reveal the anti–inflammatory activity of 4–HPPA, one of the microbiota products of flavonoids (especially naringin) found in many fruits, in an in vitro LPS (lipopolysaccharide) stimulated kidney inflammation model. HEK 293 kidney cells of human origin were used as material in the research. The trial consisted of 4 groups: control group, LPS group, 4–HPPA group and 4–HPPA+LPS group. LPS and 4–HPPA were applied to the cells at different concentrations for 24 hours. Effective concentrations of LPS and 4–HPPA were investigated by MTT viability test. Finally, IL–1β, TNF–α and NFkβ gene expression analyzes responsible for inflammatory responses were investigated by qRT–PCR method. According to the findings, after 24 hours of incubation, LPS at 2.5 ng·mL-1 and 4–HPPA at 6.25 μg·mL-1 were determined to be effective concentrations for the experiment. Again, it was observed that 4–HPPA downregulated LPS–induced IL–1β, TNF–α and NFkβ gene expressions by 7, 42 and 40%, respectively. According to the data obtained from the research, it was revealed that 4–HPPA had effective anti–inflammatory properties in the in vitro LPS–stimulated kidney inflammation model. However, it was concluded that in vivo and more advanced molecular methods are needed to fully elucidate the issue.
THE EFFECT OF THE INTERVAL TRAINING METHOD ON THE SPEED ENDURANCE OF FOOTBALL PLAYERS
Authors: Khachatryan N. E.
Published: May 2024

During the competitive activity of football players, maintaining a high level of energy supply for ensuring muscle activity and special physical performance is a priority issue. Therefore, achieving and maintaining a high level of physical performance is an important factor that ensures the result.
The purpose of the research is to study the effect of interval training method on speed endurance of football players.
The following research methods were used: analysis of scientific and methodological literature, pedagogical scientific experiment, mathematical statistics.
To achieve the set goals, particularly within the framework of improving speed endurance indicators, the interval training method was chosen for comparison with small-sided games in a square as part of the research.
The research was carried out in 2022, in January-February, at Football Academy of Gyumri. 28 football players of "Shirak" and "Shirak-2" aged from 17 to 20 participated in the research: 14 athletes in experimental group and 14 in control group.
Research result analysis: In the training system for football players, practically every session involves simultaneous work in multiple power zones, where quick movements occur in both maximum and submaximal zones. This, in turn, contributes to the reduction of both creatine phosphate and glycogen reserves in the muscles.
To ensure the proper level of recovery for various energy substrates, it is necessary to carefully select methods and means to achieve the set goals, promoting the growth of both the organism functional capabilities and the concentration of macro ergonomic compounds. This is aimed at increasing speed-strength performance and endurance.
During the 6 weeks, the football players trained five times a week, using the interval method once a week in the first, third and sixth weeks and twice in the second, fourth and fifth weeks, respectively.
As an interval method 8 times 35m running at maximum speed with 1.5 minute rest intervals (slow running) was used in the experimental group.
The control group performed a two-minute game in a square (12x12) 5 times for 30 seconds with intervals.
The results obtained during the research reveal that there were significant differences in the indicators in both the experimental and control groups, but the increase in the indicators in the experimental group was more vivid: 4.23% and 2.16%, respectively.
Like the interval method, the game in the square contributes to the improvement of the speed endurance of the football players. Along with that, it was revealed that the use of the interval method is more effective for developing the speed endurance of football players. A trend of significant difference between groups was recorded (р <0.05).
From God to Orphan: The Deep Humanity and Deep Ecology of Limba Palm Wine Practice
Authors: Paracka Jr. Daniel J. , Vaught Seneca D.
Published: May 2024

This article’s research situates the local values, livelihoods, and stories of Limba palm wine practice within a discourse of ecospirituality and environmental sustainability using interdisciplinary methods to integrate perspectives from diverse fields including religious studies, peace studies, and Africana studies. Our longitudinal analysis incorporates field research conducted among the Limba of Sierra Leone between 1961 to the present by multiple researchers, providing an in-depth examination of palm wine traditions contextualized across a range of West African communities. The authors assert that Limba palm wine tapping has helped sustain important values and ways of life throughout a turbulent history encompassing periodic episodes of ethnic conflict, structural and traumatic violence, and environmental instability. Thus, Limba palm wine culture demonstrates how Indigenous knowledge, honored traditions, and sacred rituals empower spiritual and ecological worldviews that speak directly to processes of reparative reconciliation and resiliency.
Características dos diagnósticos de HIV/AIDS nos anos pré-pandêmicos e pandêmicos da COVID-19 em serviços de referência apoiados pela AIDS Healthcare Foundation na região metropolitana do Rio Grande do Sul, Brasil
Authors: Acosta Lisiane , Ikeda Maria Leticia Rodrigues , Barcellos Nemora Tregnago , Ávila Simone , Soares Cassiana Borges , Milagre Luciana , Martins Rafael , Rocha Andrei da , Thomazi Guilherme
Published: May 2024

Introdução: A pandemia da COVID-19 parece ter apresentado impacto na detecção e na assistência de pessoas que vivem com HIV/AIDS (PVHA), com diminuição de diagnóstico de HIV/AIDS, segundo dados epidemiológicos nacionais e internacionais. Nesse período, especificamente em setembro de 2020, o projeto denominado “Vinculação e retenção de pessoas com HIV em serviços públicos de saúde: um projeto demonstrativo na Região Metropolitana de Porto Alegre, RS, Brasil”, em uma parceria entre Aids Healthcare Foundation (AHF), Universidade do Vale do Rio dos Sinos (UNISINOS) e Secretaria da Saúde do Rio Grande do Sul (SES/RS), foi iniciado em quatro Serviços de Assistência Especializada ao HIV/AIDS (SAE) com equipes multiprofissionais. Objetivo: Conhecer e comparar o número e as características dos casos com diagnósticos nos anos pandêmicos (2020 e 2021), em relação aos anos pré-pandêmicos (2018 e 2019), ingressos nos SAE com projeto AHF/UNISINOS/SESRS. Métodos: Estudo observacional transversal analítico com utilização do banco de dados desenvolvido no projeto. Resultados: Houve mais casos com diagnóstico no ano de 2021, e o grupo dos anos pandêmicos foi superior numericamente ao grupo dos anos pré-pandêmicos: um total de 647 casos em relação a 565, um aumento de 82 casos, ou seja, 14%. Variáveis sociodemográficas, como sexo e raça/cor, mostraram diferença significativa (p<0,05), assim como clínicas, com valor de CD4 inicial, e assistenciais, como terapia antirretroviral (TARV) oportuna e SAE. Conclusão: Foi constatado um aumento de ingressos de pessoas com diagnóstico de HIV/AIDS nos anos pandêmicos da COVID-19 nos serviços com o projeto AHF/UNISINOS/SESRS, apesar de boletins epidemiológicos municipais, estaduais e nacionais terem demonstrado uma diminuição de casos no período. Essa diferença pode ser decorrente do fato de o projeto ter iniciado em um nível especializado e secundário de assistência ao HIV/AIDS no momento em que a assistência primária apresentava uma demanda exacerbada em razão da pandemia da COVID-19.
Análise dos óbitos por sífilis congênita do estado do Rio de Janeiro no período de 2020 a 2022
Authors: Faria Luiza Carneiro da Cunha , Gomes Juliana Rebello , Pires Denise Ribeiro Franqueira , Lemos Elizabeth Borges , Teofilo Marcella Martins Alves
Published: May 2024

A sífilis congênita é uma doença de notificação compulsória que demanda ações de saúde no Brasil e no mundo, e que apresenta o estado do Rio de Janeiro (ERJ) como um dos estados brasileiros com as maiores taxas de incidência e coeficiente de mortalidade infantil específica para a doença. O objetivo foi analisar dados de mortalidade por sífilis congênita ocorridos no período de 2020 a 2022 no ERJ. Trata-se de um estudo epidemiológico descritivo no qual foram analisados os óbitos por sífilis congênita no ERJ, sem identificação, retirados do Sistema de Informação sobre Mortalidade (SIM), do Sistema de Informações sobre Nascidos Vivos (SINASC) e do Sistema de Informação de Agravos de Notificação (SINAN). O período analisado compreendeu o triênio 2020 a 2022, e a coleta de dados ocorreu em abril de 2023. No período de 2020 a 2022, quanto à mortalidade infantil (em menores de 1 ano) por sífilis congênita, foi declarado, no SIM, 562 óbitos, sendo 432 (76,9%) na região metropolitana I, 53 (9,4%) na região metropolitana II, 1 (0,2%) na região Noroeste Fluminense, 23 (4,1%) na região Norte Fluminense, 17 (3%) na região Serrana, 15 (2,7%) na região da Baixada Litorânea, 9 (1,6%) na região do Médio Paraíba, 2 (0,4%) na região do Centro-Sul Fluminense e 12 (2,1%) na região da Baía da Ilha Grande. Houve um declínio dos óbitos nesse período; os casos concentram-se na capital podendo estar atrelado ao número de habitantes. O pré-natal é de extrema importância para evitar o pior desfecho.
Epidemiologia dos idosos vivendo com HIV no estado do Pará
Authors: Cruz Neto Manoel Samuel da , Miranda Andrea Carolina Chagas de , Oliveira Isis Mendes , Santos Marcos Vinicius Neves dos , Almeida Reginaldo Barata de , Ferreira Rosicleia da Silva de Sousa , Reymão Tammy Kathlyn Amaral
Published: May 2024

O avanço científico da Medicina trouxe longevidade à sociedade, proporcionando o aumento da atividade sexual entre as pessoas idosas. Entretanto, as medidas preventivas contra infecções sexualmente transmissíveis (IST) entre os idosos não acompanharam tal evolução. O objetivo deste trabalho foi identificar a epidemiologia da infecção por HIV entre idosos no estado do Pará. Trata-se de um estudo epidemiológico descritivo; os dados para a série histórica foram obtidos junto ao Sistema de Informação de Agravos de Notificação (SINAN), estratificando-se indivíduos com idade ≥60 anos, notificados no estado do Pará entre 2012 e 2022. As informações foram transcritas no Excel e analisadas com o programa SPSS 13.0. O nível de significância considerado foi 945 = 0,05, intervalo de confiança de 95%. Nos últimos 10 anos, foram notificados 774 indivíduos com idade ≥60 anos, representando 5,9% do total de casos no estado; o índice é superior à média nacional, destacando-se os anos de 2020 a 2022, período da pandemia da COVID-19 com salto da onda epidemiológica. Identificou-se que os homens representam a maioria dos casos, entretanto, a proporcionalidade em relação às mulheres vem diminuindo a cada ano. Ademais, houve prevalência entre idosos de origem parda, com baixa escolaridade e residentes na região metropolitana de Belém, respondendo por 30,8% dos casos. O teste de χ2 de Person revelou que as variáveis “categorias de exposição” e “raça” tiveram relevância estatística, quando analisadas segundo o recorte etário. Quanto ao óbito por AIDS, identificou-se taxa 6,3% entre o grupo na série histórica pesquisada. O crescimento da infecção pelo vírus do HIV é uma realidade entre os idosos, fazendo-se necessário que os gestores e profissionais de saúde se sensibilizem afim de realizar campanhas públicas de prevenção direcionadas, bem como compreendam que o aumento da incidência do HIV se deve às causas multifatoriais nessa população.
A Thematic Analysis Of Textbook Graffiti By UNRWA Preparatory School Students In Jordan From The View Of Sociolinguistics As An Act Of Vandalism
Authors: Hussein Abdullah , Subramaniam Ilangko , Sweidan Mo’ath
Published: May 2024

Though graffiti has become a significant cultural and linguistic phenomenon that has been studied throughout history, there is still room for further investigation into how graffiti in various contexts, particularly in a primary education institution, serves to voice students’ thoughts and feelings. As a result, this study investigated the common themes as well as the lexical and syntactic elements of graffiti written on students’ textbooks at four UNRWA preparatory schools in Amman, Jordan. This study found that students' graffiti covered a wide range of themes, including love and hate as the most dominant themes and faith and religion as the least prevalent themes. The data analysis also found examples of lexical features such as autonomies and repetitions. The most common lexical feature observed in students’ graffiti was antonymy, while swear words were the least common feature. The findings provided great value to those interested in studying social, sociological, sociolinguistic and psychological issues as they explained some of the themes that help reveal the values and cultural norms of students’ society. The findings also offered a valuable source of data for those in education, especially teachers, school principals, school counsellors and education stakeholders to understand students’ community in an attempt to construct a conducive, supporting and peaceful learning environment and ultimately improve students’ achievements and performance.
Penguatan Kapasitas dan Tata Kelola Keuangan BUMDes di Desa Oinbit Kecamatan Insana
Authors: Be Emanuel , Oki Kamilaus Konstance , Babulu Natalia Lily
Published: May 2024

BUMDes yang dimiliki oleh desa Oinbit sejak didirikan tahun 2017. Sesuai dengan AD/ART BUMDes desa Oinbit, kegiatan awal yang dijalankan oleh BUMDes Oinbit adalah dibidang peternakan, yakni didistribusikannya hewan ternak berupa anakan babi kepada masyarakat yang akan dipelihara selama 1 tahun dan akan djual kembali pada tahun berikutnya. Kegiatan pengabdian ini dilakukan untuk memberikan pelatihan berkaitan dengan penguatan kapasitas dan tata Kelola keuangan BUMDes di Desa Oenbit Kecamatan Insana Kabupaten Timor Tengah Utara. Peserta pelatihan terdiri dari 20 orang Masyarakat berserta aparat Desa. Tujuan dari pengabdian ini untuk memberikan pememahaman kepada Masyarakat Desa Oenbit Kecamatan Insana terkait dengan penguatan kapasitas dan pengelolaan keuangan BUMDes. Metode kegiatan pengabdian kepada Masyarakat melalui pelatihan, pendampingan, dan revitalisasi sesuai kondisi dan tahap perkembangan BUMDes. Hasil pengabdian yang dilakukan Masyarakat khususnya yang terlibat didalam BUMDes lebih memahami berkaitan dengan penguatan kapasitas dan pengelolaan keuangan BUMDes.
Upaya Peningkatan Pengetahuan Ibu Tentang Pentingnya Mobilisasi Dini Ibu Nifas
Authors: Prisusanti Retno Dewi , Putri Santy Irene , Ka’arayeno Arie Jefry
Published: May 2024

Pemberian pendidikan kesehatan tentang mobilisasi dini masa nifas bisa dilakukan dengan cara memberikan konseling tentang mobilisasi dini pada ibu nifas. Pemberian konseling yang dilakukan pada ibu post partum bertujuan meningkatkan pengetahuan ibu nifas tentang mobilisasi dini masa nifas, dengan demikian diharapkan bisa merubah perilaku ibu nifas untuk melakukan mobilisasi dini. Kegiatan pengabdian ini dilaksanakan di RSUD Bangil Kabupaten Pasuruan. Metode kegiatan dalam penyuluhan ini adalah melalui ceramah, demostrasi dan tanya jawab, uraian secara terinci tentang metode dapat dilihat pada tabel tahap kegiatan. Setelah itu dilakukan evaluasi setiap kegiatan apakah intervensi yang sudah dilakukan secara optimal oleh peserta, pada tahap evaluasi ini dilakukan 2x dan pada pertemuan terakhir dilakukan evaluasi pengetahuan ibu tentang mobilisasi dini. Berdasarkan tujuan yang ingin dicapai dalam kegiatan ini, diperoleh hasil bahwa pengetahuan peserta setelah penyuluhan lebih baik dibanding sebelum penyuluhan. Hasil observasi dan wawancara menunjukkan bahwa peserta sangat kooperatif dalam mengikuti kegiatan ini sampai berakhir.
Peningkatan Skill Web Programming Menggunakan Framework Laravel Bagi Siswa Jurusan RPL SMKN 7 Pekanbaru
Authors: Winarso Doni , Arribe Edo , Hafsari Rizka , Wijaya Setyawan Ardhi , Syahril Syahril , Aryanto Aryanto , Diansyah Risnal , Mulyana Wide , Muslim Nurul Alifa Putri
Published: May 2024

Web telah menjadi kebutuhan penting diera kehidupan modern saat ini. Hal tersebut mendorong lembaga pendidikan formal untuk mempersiapakan tenaga kerja terampil yang siap pakai. Salah satunya adalah Sekolah Menengah Kejuruan (SMK) Jurusan Rekayasa Perangkat Lunak(RPL). Tujuan kegiatan ini untuk meningkatkan keterampilan web programming menggunakan framework Laravel bagi siswa jurusan RPL di SMKN 7 Pekanbaru. Melibatkan 34 peserta, kegiatan dilakukan dengan memperkenalkan serta memberikan pelatihan praktis dalam penggunaan Laravel. Metode pelatihan yang digunakan mencakup pengenalan konsep dasar Laravel, pembuatan aplikasi web sederhana, dan penerapan praktik terbaik dalam pengembangan web. Evaluasi dilakukan melalui tes keterampilan dan penilaian hasil proyek yang telah dibuat oleh peserta. Hasil dari pengabdian ini menunjukkan peningkatan signifikan dalam pemahaman dan keterampilan siswa dalam penggunaan Laravel sebagai framework pengembangan web. Kesimpulannya, pengabdian ini berhasil memberikan kontribusi positif dalam meningkatkan kompetensi siswa RPL SMKN 7 Pekanbaru dalam bidang pemrograman web menggunakan framework Laravel.
Caracterización clínico epidemiológica de pacientes pediátricos con profilaxis postexposición no ocupacional al VIH. Hospital Mario Catarino Rivas
Authors: Puerto Eloa , Erazo Karen
Published: May 2024

Antecedentes: La agresión sexual, sigue siendo la principal causa de exposición al VIH no ocupacional en niños; se presenta en todas las clases socioeconómicas, y casi en todos los países del mundo únicamente con diferencias en la magnitud.Objetivo: Identificar las características clínico epidemiológicas de los pacientes pediátricos que recibieron profilaxis post exposición no ocupacional en el Hospital Nacional Doctor Mario Catarino Rivas de enero 2020 a septiembre 2021.Pacientes y métodos: se trató de un estudio cuantitativo con un enfoque descriptivo y un diseño no experimental transversal, donde se realizó la revisión de 18 expedientes de pacientes que recibieron la atención inmediata posterior a la exposición no ocupacional al VIH, utilizándose cómo método de recolección la ficha epidemiológica del Protocolo de profilaxis Post Exposición PPE al VIH y otras ITS (Infecciones de transmisión Sexual) de la Secretaria de Salud de Honduras 2017 modificada para esta investigación. Resultados: El 78,0% de los casos se encontraron en el grupo etario de adolescentes, en su mayoría de sexo femenino y el 83,0% de los casos provenían del departamento de Cortés. La agresión sexual fue la causa más frecuente, donde el 44,0% resultó haber tenido exposición en su hogar; siendo el agresor un pariente o conocido en el 52.8%. Así mismo, el 94,1% de la serología del agresor para VIH era desconocida. Al momento de captación el 89,0% de los casos tenían una serología de VIH negativa, al mes de seguimiento el 46,6% presentó una serología negativa. Sin embargo, a los 12 meses el 100% de los casos fueron perdidos en seguimiento. Únicamente el 53,8% cumplió con la profilaxis con terapia antirretroviral y el 88,0% con la profilaxis para infecciones de transmisión sexual.Conclusiones: El incumplimiento del protocolo es atribuible a la situación por la pandemia de COVID-19 y/o al desconocimiento general de la población sobre la importancia del cumplimiento total del mismo.
From Bronchial Asthma to Tuberculosis: Unravelling the Cytokine-Macrophage Axis in Diverse Diseases
Authors: Yadav Pramod
Published: May 2024

Cytokines, tiny proteins secreted by cells, play a critical role in mediating communication and interactions between cells. They also function as immunomodulating agents, adjusting immune responses. When released into the bloodstream or tissues, cytokines bind to specific receptors on target immune cells, triggering cellular responses. Cytokines are implicated in various diseases, including asthma, COPD, HIV infection, and multiple sclerosis. This review delves into the intricate interplay between cytokines and macrophages, focusing on their roles in inflammation and the immune response. Macrophages, which are scavenger cells of the immune system, exhibit remarkable heterogeneity, reside in diverse tissues, and play crucial roles in both innate and acquired immunity. They can be activated for proinflammatory or anti-inflammatory functions, contributing to tissue destruction or regeneration. Cytokines influence macrophage activation and polarization, impacting the inflammatory process. Dysregulated cytokine production and macrophage activation are observed in various diseases. For example, in asthma, an imbalance in macrophage phenotypes contributes to airway hyperresponsiveness. Understanding the complex interplay between cytokines and macrophages is crucial for developing novel therapeutic strategies for inflammatory diseases. Future research directions include utilizing humanized animal models, single-cell sequencing, and immunomodulatory therapies to further decipher the intricate roles of cytokines and macrophages in health and disease. Ultimately, elucidating these interactions holds immense potential for improving human health outcomes.
Quantify the Influence of Coral Reef Bleaching on Tourism in Small Island Developing States (SIDS)
Authors: Xia Xintong , Yao Junyi , Mou Chenhui
Published: May 2024

As global climate change keeps deteriorating, adverse effects have emerged, including global warming, rising sea levels, and extreme weather. From diverse literature, we summarized that these effects have triggered irretrievable damage to coral reefs worldwide and indirectly influenced tourism in small island developing states (SIDS). Since the economy depends drastically on tourism, we propose the study to quantify the effect caused by coral bleaching, a by-product of global warming, on tourism in SIDS. We schedule to find the relationship between coral bleaching rate and tourism development in targeted areas via a panel data model and a regression model. We expect our result can contribute to part of the ministries' legislation in SIDS
Correlation Between News and Stock Price Based on Stock Market Indices: Can News Classification Be Used as a Tool to Make Better Decisions?
Authors: Jin Zekai , Ma Martin , Zhou Zihao , Gan Shulan , Min Yuhan
Published: May 2024

The stock market is influenced by various factors, including news events, economic indicators, and investor sentiment. Understanding the correlation between news and stock price movements interests market participants and researchers. In this paper, we explore the relationship between news sentiment and stock market trends using stock market indices. We employ natural language processing (NLP) techniques to classify news articles and analyze their impact on stock market indices, focusing on the S&P 500 and the Dow Jones Industrial Average. We utilize sentiment analysis and machine learning algorithms, including Random Forest, Loughran-McDonald (2014) Financial Sentiment Word Lists (Extended), and AFINN Lexicon, to predict stock market trends based on news sentiment. Our findings demonstrate that positive news sentiment has a more significant impact on stock prices than negative sentiment. The Random Forest model achieves the highest accuracy, while domain-specific lexicons provide valuable insights into financial news sentiment. However, predicting negative trends remains a challenge across all methods. Our research contributes to the growing knowledge of the relationship between news and stock prices and provides valuable insights for market participants and researchers.
Shadow Banking in the United States: Emerging Factors, Operation Modes and the Current Situation of Supervision - Based on the Comparison with Chinese Shadow Banking System and Market
Authors: Chen Leyan , Huang Yuqi , Mou Ruizhuo
Published: May 2024

In 2009, Ben Bernanke, chairman of the Federal Reserve, described shadow banking as a financial intermediary that converts savings into investments in addition to regulated deposit-taking institutions. To put it simply, the essence of shadow banking is a financial innovation that breaks through traditional financial institutions in order to maximize profits in the financial market environment. In this paper, we compare the U.S. and Chinese shadow banking system and their market system. From that, we analyze their similarities and differences from the aspects of emerging factors, classification and scale, and operation mode. Based on the above analysis, we then discuss the current situation of supervision of shadow banking in the United States and find that the U.S. shadow banking is negligent in institutional constraints and has practical difficulties in legal supervision. Finally, we put forward some suggestions on the future development and financial structure optimization of shadow banking.
The Collapse of Silicon Valley Banks Improves Risk Management for Other Commercial Banks
Authors: Xia Yingying , Zhang Ziheng
Published: May 2024

Silicon Valley Bank, a subsidiary of Silicon Valley Bank Financial Group, provides loans to venture capital as well as startups. Silicon Valley Bank primarily serves technology-based companies. Our paper focuses on the implications of the Silicon Valley bank bankruptcy for other commercial banks from four aspects. First, what are the risks in the business operation model of Silicon Valley banks; second, what caused the bankruptcy of Silicon Valley Bank; Third, the impact of the bankruptcy of Silicon Valley Bank; Fourth, the bankruptcy of Silicon Valley Bank has implications for the development of Chinese commercial banks. The main reason for the bankruptcy of Silicon Valley Bank was the Fed's interest rate hike. As a traditional commercial bank, Silicon Valley Bank's profit model is mainly based on interest differential. Affected by the epidemic, the demand for loans from Silicon Valley banks declined, so Silicon Valley banks chose to buy US Treasury bonds and MSBs. The Fed's interest rate hike coupled with a large amount of money printing in the United States has led to inflation. The sharp depreciation of US Treasuries and MSBs, coupled with the end of the mobile Internet cycle, forced Silicon Valley banks to sell a large number of unmatured bonds. Eventually a bank run occurred, leading to the bankruptcy of Silicon Valley Bank.
A SWOT Model-Based Analysis of Marketing Strategy Taking Mixue Ice Cream and Tea as an Example
Authors: Ou Zhida
Published: May 2024

Peoples living needs have become increasingly diversified as a result of the rapid development of the economy. In recent years, the freshly-made tea beverage industry has seen a surge in popularity, with numerous tea beverage brands entering the market. The tea industry has formed a fruit-flavored tea and milk tea beverage model based on high-quality tea, gradually replacing the dominant position of tea powder preparation in the past In order to obtain a place in the fierce market competition, the majority of tea brands must fully understand the market changes and their own development status, and formulate long-term development strategies. This paper takes Mixue Ice Cream and Tea (hereinafter referred to as MIXUE) as the research object and uses the SWOT model to analyze its strengths, weaknesses, opportunities and threats. Besides, we analyze and study its own status quo in the construction of internal control. We also formulate future marketing and development strategies for MIXUE, aiming to improve its brand competitiveness and help it to achieve substantial development.
The impact of radio on the construction of smart cities
Authors: YOU XUMING,
Published: May 2024

In the process of smart cities, radio technology has played an increasingly important role. With the continuous acceleration of the global urbanization process, cities are facing many challenges. Driven by the governments vigorous support and business promotion, wireless communication technology has developed rapidly, and new wireless communication technology has continued to emerge, providing more choices and possibilities for smart city construction. This article reviews and analyzes the actual case analysis, studies the impact of radio technology on the construction of smart cities, while explaining the importance of radio security management. The results showed that the application of radio technology enabled smart cities to achieve functions such as intelligent traffic management, intelligent communication, and intelligent energy management, but there were also problems such as leakage privacy, signal interference, and imbalance in regional development. In the process of future smart city construction, it is necessary to further optimize the safety and popularity of radio, promote the use of radio, narrow the gap between the use of different regions and cities, and enhance the radio management, so that it can better serve the construction of smart cities.
Optimization research of handwritten digit recognition algorithm based on hardware neural networks
Authors: Hu Huaijin
Published: May 2024

In the modern era of digitization, the widespread application of handwritten numerical data has led to an exponential increase in data volume, necessitating efficient real-time recognition and processing systems. This project is grounded in the foundational structure of neural networks, with a specific focus on integrating these networks into hardware through Very-Large-Scale Integration (VLSI). The primary objective is to achieve faster processing speeds, lower power consumption, and real-time operations. The central emphasis of this study is the design and implementation of a hardware neural network system tailored specifically for handwritten digit recognition. Drawing from neural network theory, we explore the construction of a hardware-based handwritten digit classifier. The fundamental model employed is the single-layer perceptron neuron model. Upon receiving 28x28 pixel grayscale images, the image classifier utilizes pre-trained weights, activation functions, and a maximum selector to compare and output recognition results for numerical digits. The concrete implementation is realized using the Verilog hardware description language, coupled with algorithm optimization strategies to enhance performance and efficiency. This research endeavor aims to provide an effective hardware solution for real-time handwritten digit recognition in the digital age.
Automated Data Quality Control System in Health and Demographic Surveillance System
Authors: Tlouyamma Joseph , Mokwena Sello
Published: May 2024

The automated data quality management system serves as a comprehensive solution developed to enhance the precision, dependability, and uniformity of data within data-driven organizations. Such systems play an important role in eliminating the shortcomings associated with manual data quality management, which is prevalent in health and demographic surveillance systems (HDSS). The ongoing difficulty of ensuring data quality through manual processing hinders the HDSS's capacity to optimize data quality effectively. To address this challenge, our study adopted design science methodologies to provide guidelines for the design and implementation of the automated data quality control system. The open source technologies (Pentaho data integration, R Studio, SQL, Windows task scheduler) were used to facilitate the automation and validation of the incoming and database resident data. The quality of data has vastly improved since the implementation of the proposed system. The findings suggest that the automated data quality control system exhibited superior performance compared to the manual methods, thereby minimizing errors and time-wasting efforts.
Management and Utilization Strategies of Educational Management Information Systems to Enhance Students' Academic Performance
Authors: Pramono Susatyo Adhi , Hanif Muh. , Kraugusteeliana Kraugusteeliana
Published: May 2024

Conventional educational management systems often face limitations in handling student data, curriculum, and other academic processes, leading to difficulties in effectively monitoring and enhancing students' academic performance. With the rapid advancement of information technology, the use of management information systems in educational contexts has become increasingly crucial. This research aims to examine the management and utilization strategies of management information systems in enhancing students' academic performance. The methodology employed in this research is a literature review using a qualitative approach and descriptive analysis. Descriptive analysis is utilized to present characteristics, patterns, and trends emerging from data obtained from articles published on Google Scholar between 2007 and 2024. Theme identification is one of the research data analysis techniques. The main themes in the article were identified, focussing on aspects such as information systems, education management, and student academic performance. The study results indicate that the utilization of Management Information Systems (MIS) has demonstrated a significant role in enhancing efficiency and effectiveness across various fields, including education. In the educational context, the management of MIS can be a key factor in improving students' academic performance
Strategi Rekrutmen Pendidik dan Tenaga Kependidikan dalam Penempatan Kerja di MAN 2 Sijunjung
Authors: Jamilus Jamilus , Alwis Dona Ana Yori
Published: May 2024

This article investigates various strategies used in the recruitment of educators and education personnel for effective job placement. This study used a qualitative approach with a descriptive method. The subjects of the study were selected using purposive sampling techniques. Data collection is carried out directly through observation and interviews. Data analysis is carried out qualitatively with stages of data reduction, data presentation, and conclusion drawing. The results show that diverse approaches have been used by educational institutions and organizations to attract qualified individuals into these educational roles. An effective recruitment strategy is not just about finding academically qualified candidates, but also about considering the cultural fit and values of the organization. This article also discusses challenges in the recruitment of educators and education personnel, such as job market competition and changes in education trends. A holistic and continuous approach in the development of recruitment strategies that can adapt to the changing dynamics in the world of education and the job market. This research is in the form of interviews, literature studies, where the author collects data from various references such as books, and scientific articles.
Manajemen Sumber Daya Manusia dalam Pendidikan Islam (Studi Kasus di SD Plus Lillah Pasir Putih)
Authors: Zurhidayati Zurhidayati , Jamilus Jamilus
Published: May 2024

This research will explain related to the concept of human resource management in Islamic education. The study used descriptive qualitative methods implemented by collecting data obtained from documentation, observation, and interviews. The results showed that SD Plus Lillah Pasir Putih meets the needs of teachers / educators and education staff in accordance with needs such as administrative personnel, cleanliness, and security. HR competencies are enhanced through education and training, seminars, workshops, and internships. Recruitment and selection of HR candidates is carried out every year since its establishment, along with the development of the school and the increase in the number of students. Meanwhile, compensation, both financial and non-financial, is always improved to provide qualified quality human resources. The implementation of Islamic Education Human Resources in Plus Lillah Pasir Putih has been well implemented, especially in the field of HR management, ranging from HR planning, recruitment, selection of HR candidates, training, and development, to employee relations
Even Semester Students’ Perception on English Language Learning Conducted Online
Authors: Erwita Ika , Lase Ertaniat , Waruwu Yaredi
Published: May 2024

This research aims to gain in-depth insight into students' perception on online English learning. In the face of the digital age, online learning has become a major alternative in higher education. However, the understanding of how students assess this learning experience is still evolving. The type of research method used is quantitative research with a data collection model using a questionnaire, which was distributed to students through Google Forms to all participants of this study and the data was analyzed using descriptive statistics to get the percentage of students' perspectives. The results showed that, from the perceptions of students who became participants in this study, felt that online English language learning did not fully help the learning process to be more effective and preferred English language learning conducted face-to-face
İPOTEKLİ TAŞINMAZIN DEVRİ HALİNDE BORCUN ÜSTLENİLMESİ
Authors: Kartal Dilşah Buşra
Published: May 2024

Borcun üstlenmek isteyen kişi, alacaklı ile akdedeceği borcun dış üstlenilmesi sözleşmesi ile bu işlemi gerçekleştirebilir. TBK m. 195 vd.’nda borcun üstlenilmesinin şartları ve hukuki sonuçları düzenlenmiştir. TBK m. 204’te rehinli taşınmazın devrinde borcun üstlenilmesine ilişkin özel hükümlerin saklı tutulduğu hüküm altına alınmıştır. MK m. 888/II de saklı tutulan söz konusu özel düzenlemelerden biridir. MK m. 888/II’ye göre borcun üstlenilmesi için öncelikle yeni malikin borcu yüklenmesi gerekir. Bunun için yeni malik ve borçlu arasında borcun iç üstlenilmesi sözleşmesi akdedilir. Borcun iç üstlenilmesi sözleşmesi tek başına borcun yeni malik tarafından üstlenilmesini sağlamaz. Bu sözleşme tapu müdürlüğü tarafından alacaklıya bildirilir. İpotekle temin edilen alacağın devredilmesi halinde, alacak devri tapunun düşünceler sütununa işlenmediyse devreden alacaklıya yapılan bildirim kural olarak yeterlidir. Ancak alacağın devri borçluya bildirilmişse bildirim alacağı devralan alacaklıya yapılmalıdır. Keza alacak devri tapu sayfasına işlendiyse bildirim yeni alacaklıya yapılır. Alacaklı bildirimi aldığı tarihten itibaren bir yıl içinde borçluya yazılı olarak kendisine karşı olan hakkını saklı tuttuğunu bildirmezse borç yeni malik tarafından üstlenilmiş olur. Doktrinde tartışmalı olmakla birlikte, kanaatimizce MK m. 888/II uyarınca borcun üstlenilmesinin sözleşmeye dayalı olarak gerçekleştiği kabul edilmelidir. Buna göre borcun iç üstlenilmesi sözleşmesinin alacaklıya bildirilmesi dış üstlenme sözleşmesinin akdedilmesine yönelik bir öneri niteliğindedir. Alacaklının bildirimi aldıktan sonra bir yıl boyunca sessiz kalmasına kanun koyucu kabul anlamı yüklemiştir. Borcun üstlenilmesi ile birlikte yeni malik borcu üstlenirken eski borçlu da borcundan kurtulur. Borcun MK m. 888/II’ye göre üstlenilmesine TBK m. 195 vd.’nda yer alan hükümler kıyasen uygulanır. Buna göre TBK m. 198 ve TBK m. 199/I-II yeni malikin borcu üstlenmesine de uygulanır. Diğer taraftan TBK m. 199/III’ün kıyasen uygulanmasına imkan yoktur.
TAŞINMAZ SATIŞ SÖZLEŞMELERİNİN NOTERLERDE DÜZENLENMESİ
Authors: Bilen Elif
Published: May 2024

Taşınmaz mülkiyetinin devri borcu doğuran sözleşmeler, resmi şekilde yapılması gereken işlemlerdir. Noterlik Kanunu’nun 60. maddesinde yapılan değişiklikle ve Noterlik Kanunu’na 61/A maddesinin eklenmesiyle tapu müdürlüklerinin yanısıra noterlere de taşınmaz satış sözleşmesi düzenleme yetkisi verilmiştir. Noterlerin hukuki sorumlulukları, taşınmaz satış sözleşmesi düzenlemelerinden kaynaklanan zararlardan da sorumlu olacakları şekilde genişletilmiştir.
Bu çalışmada noterlik kavramı, noterlerin görevleri, taşınmaz mülkiyetinin kazanılması ve tapu sicilinin tutulmasında Devlet’in sorumluluğu konuları açıklanmıştır. Taşınmaz satış sözleşmeleri ile ilgili diğer ülke uygulamalarından örneklere değinilmiştir.
Noterlerin taşınmaz satış sözleşmesi düzenlemelerine ilişkin olarak başvuru, sözleşmenin hazırlık işlemleri ve sözleşmenin yapılması aşamaları hakkında ayrıntılı bilgiler verilmiştir. Noterlerin düzenleyecekleri taşınmaz satış sözleşmelerinden kaynaklanabilecek sorumlulukları incelenmiştir. Taşınmaz satış sözleşmesi ile ilgili yapılan yeni düzenlemelerin mevcut duruma etkileri, olumlu ve olumsuz yönleri üzerinde değerlendirmeler yapılmıştır.