bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma Purification is Associated With Reduced Inflammation Factors and Down-regulation of Lipid Metabolic and ER Stress Proteins in Patients With Hyperlipidemia
Authors: Zhang Xiao Meng , Deng Hao , Xu Zheng Quan , Zhong Ze Yuan , Jin Hui Min , Yang Xiu Hong
Published: September 2020

Background Hyperlipidemia is a strong risk factor for arteriosclerosis and cardiovascular disease (CVD). Lipid-lowering therapy using drugs often results in many side effects. The aim of our study is to investigate the potential effects of non-drug therapy by double filtration plasmapheresis (DFPP) on lipid metabolic, endoplasmic reticulum (ER) stress and apoptosis related proteins in peripheral blood mononuclear cells (PBMC) before and after lipid clear out in patients with hyperlipidemia. MethodsLipid metabolic [CD36, propotein convertase subtilisin/kexin type 9 (PCSK9) and LDL receptor], ER stress (GRP78, CHOP, ATF4, EIF2a) and apoptosis related (Bcl-2, BAX, and Caspase-3) proteins were assayed by western blot, reactive oxygen species (ROS) measured by flow cytometry (FCM) and serum inflammatory factors were detected by ELISA. Results35 patients with hyperlipidemia were selected into this study. Compared with pre-DFPP, most of lipid metabolic parameters as cholesterol, triglyceride, LDL, lipoprotein a [Lp(a)] and small dense LDL cholesterol (sdLDL) reduced. DFPP process was associated with the down-regulation of lipid metabolic, ER stress and apoptosis proteins, also resulted in the decrease in ROS and serum inflammatory factors release. Conclusion DFPP owns the capacity of lipid-lowering, also can regulate lipid metabolic, ER stress and apoptosis related proteins in PBMC and reduce inflammatory factors in patients with hyperlipidemia (ClinicalTrials.gov number, NCT03491956). Footnote: Xiao Meng Zhang and Hao Deng contribute equally to this paper.
Substance Use, and Substance Use Disorder, in Relation to COVID-19: Protocol for a Scoping Review
Authors: Kumar Navin , Janmohamed Kamila , Nyhan Kate , Martins Silvia S , Cerda Magdalena , Hasin Deborah , Scott Jenny , Pates Richard , Ghandour Lilian , Wazaify Mayyada , Khoshnood Kaveh
Published: September 2020

Background: The COVID-19 pandemic is creating severe issues for healthcare and broad social structures, exposing societal vulnerabilities. Among the populations affected by COVID-19 are people engaged in substance use, such as people who smoke, vape (e-cigarette use), use opioids, cannabis, alcohol, psychoactive prescription drugs, or have a substance use disorder (SUD).Monitoring substance use and SUD during the pandemic is essential, as people who engage in substance use or present with SUD are at greater risk for COVID-19, and the economic and social changes resulting from the pandemic may aggravate SUD. There have been several reviews focused on COVID-19 inrelation to substance use and SUD. Reviews generally did not consider on a large range of substance use variants or SUDs. We plan a scoping review that seeks to fill gaps in our current understanding of substance use and SUD, in theCOVID-19 era.Methods: A scoping review focused on substance use and SUD, in relation to COVID-19, will be conducted. Databases such as MEDLINE, Embase, PsycINFO, Global Health, and Sociological Abstracts will be searched to capture current literature and preprints. Study selection will conform to Joanna Briggs Institute Reviewers’ Manual 2015 Methodology for JBI Scoping Reviews.Results: N/AConclusions: Original research is urgently needed to mitigate the risks of COVID-19 on substance use and SUD. The planned scoping review will help address this gap.Systematic Review registrations: N/A
Bioactive Nanofiber-based Conduits in a Peripheral Nerve Gap Management- an Animal Model Study.
Authors: Tomasz Dębski , Kijeńska-Gawrońska Ewa , Zołocińska Aleksandra , Siennicka Katarzyna , Paskal Wiktor , Włodarski Paweł K. , Święszkowski Wojciech , Pojda Zygmunt
Published: September 2020

Background: Peripheral nerve injuries (PNI) are trauma with severe squeals for patients’ quality of life. Currently, the gold standard of nerve reconstruction relies on primary coaptation. However, in case of a nerve gap, a reconstructive material for bridging is needed. Nerve conduits are an increasingly popular solution alternative to autografts or processed nerved allografts. The aim of the study was to examine the efficiency of a novel bioactive nanofiber-based tubular scaffold made of poly (L-lactic acid)-co-poly(ϵ-caprolactone), collagen, polyaniline and enriched with adipose-derived stem cells (ASCs) as a nerve conduit in a rat model.Methods: Poly (L-lactic acid)-co-poly(ϵ-caprolactone) scaffold was optimized and enriched with collagen (COL) and polyaniline (PANI) to create final (P(LLA-CL)-COL-PANI), tubular-shaped scaffold, manufactured with electrospinning technology. Parallelly, adipose tissue from 10 Lewis rats was harvested for ASC culture. 28 inbred male Lewis rats were divided into four even groups. Each animal underwent sciatic nerve transection and excision of a 10 mm nerve trunk fragment. In group A, nerve gap remained untouched, in B excised trunk was rotated and used as an autograft, in C nerve stumps were secured with P(LLA-CL)-COL-PANI conduit. In the D group gap was reconstructed with P(LLA-CL)-COL-PANI conduit enriched with ASCs. After 6-months of observation rats were sacrificed. Gastrocnemius muscles (operated and non-operated side) and reconstructed sciatic nerves were harvested for analyses. Muscles were weighted and underwent histological analysis. Nerves were processed and stained immunohistochemically with NF-200 to be analyzed with dedicated software for nerve fiber count. Results: No signs of rejection or excessive fibrosis was noted. Muscle mass ratio was highest in group B (0.77±0.05), then in C (0.74±0,04) and D (0.67± 0.07). Group A showed advanced atrophy of the muscle, each intervention prevented muscle mass decrease (p<0.0001), however, ASC addition decreased efficiency vs autograft (p<0.05). Nerve fiber count revealed a superior effect in the nerve fiber density observed in the group with the use of conduit vs autograft (D vs B p<0.0001, C vs B p<0.001). ASC added to the conduit decreased perineurium hyperplasia.Conclusion: P(LLA-CL)-COL-PANI conduits with ASC showed promising results in managing nerve gap by decreasing muscle atrophy and providing a favorable environment for peripheral nerve regeneration.
GENDER IN ISLAMIC INHERITANCE
Authors: Rahmatullah Rahmatullah
Published: September 2020

This article examines a debate on gender equality, which is considered by some to be in conflict with the Qur’an, an-Nisa [4]:11. Using a philosophical approach and analyzing Sa‘ id Ramadan al-Buti’s concept of inheritance in his Al-Mar’ah Bayna Tughyan al-Nizam al-Gharbi wa Lata’if al-Tashri’ al-Rabbani, this paper tries to refute this allegation and offers a more gender-friendly interpretation. For al-Buti, the verse has actually liberated women because the provisions are caused by the responsibilities imposed by Islam on men as prospective husbands, not on women. On the contrary, if women are more empowered than men, that becomes a moral issue, not a shari’a one. Women have been given freedom by the shari’a in order to determine their choice to participate in bringing about stability in life. A condition that women are more empowered than men will not be the cause of changes in the shari’a’s provisions concerning inheritance.
Identification of Sand Flies (Diptera: Psychodidae) Collected from Cutaneous Leishmaniasis Endemic Focus in the Ho Municipality, Ghana
Authors: Doe Edna Dzifa , Kwakye-Nuako Godwin , Addo Seth Offei , Egyir-Yawson Alexander
Published: September 2020

Leishmaniasis, is a vector-borne disease transmitted to humans through the bite of infected female sand flies. Active and continuous monitoring of the sand fly is an important aspect of disease control. Thus, the correct identification of its vectors is paramount in this regard. Objective: The study was conducted to morphologically and molecularly identify female sand fly species in a cutaneous leishmaniasis endemic focus collected in three villages in the Ho Municipality of the Volta region. CDC light traps and sticky paper traps was used for the collection of the sand flies. The morphologically identified sand flies was molecularly confirmed by running PCR with the mitochondrial cytochrome c oxidase gene subunit I (COI) primers and DNA sequenced. A total of 537 sand flies was collected, made up of 363 females and 174 males.  Eleven different species of sand flies was morphologically identified – one Phlebotomus species and ten Sergentomyia species. The PCR amplified products showed bands of molecular weights 658 base pairs for the primers. The molecular identification using the 658-bp fragment of the (COI) gene was congruent with the morphological identification.
Finite temperature and quench dynamics in the Transverse Field Ising Model from form factor expansions
Authors: Granet Etienne , Fagotti Maurizio , Essler Fabian
Published: September 2020

We consider the problems of calculating the dynamical order parameter
two-point function at finite temperatures and the one-point function
after a quantum quench in the transverse field Ising chain. Both of
these can be expressed in terms of form factor sums in the basis of
physical excitations of the model. We develop a general framework for
carrying out these sums based on a decomposition of form factors into
partial fractions, which leads to a factorization of the multiple sums
and permits them to be evaluated asymptotically. This naturally leads
to systematic low density expansions. At late times these expansions
can be summed to all orders by means of a determinant
representation. Our method has a natural generalization to semi-local
operators in interacting integrable models.
The Refinement on Character education to Strengthening Islamic Education in Industrial Era 4.0
Authors: Priyanto Adun
Published: September 2020

The research is to know the strengthening of Islamic educations in accordance with the need for the Industrial era 4.0 industrial era (turbulence era). Within those advancements, character education has become an oasis in the middle of morality decadences of millennial generation in the present society and a fort to prevent the destruction of a nation. The research method uses literature study by collecting data from documentation using the descriptive-analysis method. The results of the study concluded, Islamic education transformation is greatly required to gain solutions by strengthening Islamic educational management, Islamic educational leadership, and educational policy on character educations. Character education in Islamic Education does not only teach right or wrong but also teaches students to commit to doing the right thing. The character emphasizes practice in the students’ daily lives such as the implementation of, honest (Siddiq), trustworthy (Amanah), smart (fathonah) and conveys the truth (tabligh), in relationship, a good citizen attitude.   AbstrakMasyarakat Islam harus melakukan modernisasi pendidikan Islam dalam segala aspek pendidikan, kurikulum, tata kelola institusi, model dan strategi pembelajaran sesuai dengan kebutuhan era industri 4.0 (era turbulensi). Dalam kemajuan tersebut, pendidikan karakter telah menjadi oase di tengah dekadensi moralitas generasi milenial di masyarakat saat ini dan benteng pencegah kehancuran suatu bangsa. Metode penelitian menggunakan studi pustaka dengan mengumpulkan data dari dokumentasi menggunakan metode analisis deskriptif. Hasil penelitian menyimpulkan, transformasi pendidikan Islam sangat diperlukan untuk mendapatkan solusi dengan memperkuat manajemen pendidikan Islam, kepemimpinan pendidikan Islam, dan kebijakan pendidikan pada pendidikan karakter. Pendidikan karakter dalam Pendidikan Islam tidak mengajarkan benar atau salah, tetapi juga mengajarkan siswa untuk berkomitmen melakukan hal yang benar. Karakter tersebut menekankan pada praktik dalam kehidupan sehari-hari siswa seperti pelaksanaan, jujur (siddiq), amanah (amanah), cerdas (fathonah) dan menyampaikan kebenaran (tabligh), dalam menjalin hubungan, sikap warga negara yang baik.
De-Radicalization through Prophetic Education in High School
Authors: Solikhin Mat
Published: September 2020

This research analyze the management of de-radicalization through the prophetic education, case study in State Senior High School (SMAN 1) and State Islamic High School (MAN 1) Kendal, Jawa Tengah, Indonesia. The research used qualitative method. Data collection technique in this research are observation, interview and documentation. The results showed; 1) the humanizing human beings is the key in organizing the radicalism ideological movement in prophetic education in Indonesia. Meanwhile, in the relationship between religious values and national culture, it must provide space for pluralism and multiculturalism 2) the process of de-radicalization in prophetic education in Indonesia through prophetic values in Islamic Civilization History (Sejarah Kebudayaan Islam, SKI), Al-Qur'an, Hadith, Akidah Akhlaq, and various extra-curricular activities. Based on the evaluation conducted most of students are already good in showing anti-radicalism attitude.AbstrakPenelitian ini menganalisis pengelolaan de-radikalisasi melalui pendidikan kenabian, study kasus di Sekolah Menengan Atas 1 (SMAN 1) dan Madrasah Aliyah Negeri 1 (MAN 1) Kendal, Jawa Tengah, Indonesia. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data dalam penelitian ini adalah observasi, wawancara dan dokumentasi. Hasilnya menunjukkan; 1) bahwa memanusiakan manusia adalah kunci dalam menata gerakan ideologi radikalisme dalam pendidikan profetik di Indonesia. Sedangkan dalam relasi antara nilai-nilai agama dan budaya bangsa maka harus memberi ruang pada pluralisme dan multikulturalisme. 2) proses deradikalisasi dalam pendidikan kenabian di Indonesia melalui nilai-nilai kenabian dalam SKI, Al-Qur'an, Hadits, Akidah Akhlaq, dan berbagai kegiatan ekstra kurikuler. Berdasarkan evaluasi yang dilakukan, sebagian besar siswa sudah bagus dalam menunjukan sikap anti radikalisme.
Learning Innovation with Mobile Devices ICT In Majlis Ta’lim Raudhotun Nisa Jakarta, Indonesia
Authors: Nuraeni Heni Ani
Published: September 2020

Information Communication Technology (ICT) is a public demand in the industrial era 4.0. This study examines the use of mobile devices (ICT) in learning at the Majlis Ta’lim Raudhatun Nisa, Jakarta, Indonesia. Majlis ta'lim is a conventional Islamic educational institution for studying and practicing religious knowledge. The results of the study found that the majlis ta'lim Raudhotun Nisa was quickly responds to the demands of the times by making basic learning innovations. Learning does not only use conventional media but has used mobile devices in the form of projectors, laptops, and smartphones including WhatsApp, Facebook, and Instagram. Although most of the participants are elderly people who are not tech-savvy yet, the use of mobile devices has served as a means of socialization and communication and an effective means of modern learning. Abstrak: Teknologi Komunikasi Informasi (TIK) merupakan tuntutan masyarakat di era industri 4.0. Penelitian ini mengkaji pemanfaatan perangkat seluler (TIK) dalam pembelajaran di Majlis Ta'lim Raudhatun Nisa, Jakarta, Indonesia. Majlis ta'lim adalah lembaga pendidikan Islam konvensional untuk mempelajari dan mengamalkan ilmu agama. Hasil penelitian menemukan bahwa majelis ta'lim Raudhotun Nisa dengan cepat merespon tuntutan zaman dengan membuat inovasi pembelajaran dasar. Pembelajaran tidak hanya menggunakan media konvensional tetapi telah menggunakan perangkat mobile berupa proyektor, laptop, dan smartphone termasuk WhatsApp, Facebook, dan Instagram. Meski sebagian besar pesertanya adalah lansia yang belum paham teknologi, penggunaan perangkat seluler telah berfungsi sebagai sarana sosialisasi dan komunikasi serta sarana pembelajaran modern yang efektif.
Removal of cadmium heavy metal ions from wastewater by electrosorption using modified activated carbon felt electrodes
Authors: Rajumon Rijo , Aravind S. P. , Bhuvaneshwari S. , Ranjitha J. , Mohanraj P.
Published: September 2020

Cadmium contamination in industrial wastewater is an environmental issue posing a great threat to human and animal life. However, the available methods for the removal of cadmium at lower concentrations are limited. Such processes are often accompanied by sludge formation and lead to heavy metal wastage. This paper focuses on the application of an electrosorption process using modified activated carbon felt (MACF) electrodes for the removal and recovery of lower concentration of cadmium from a simulated wastewater sample without sludge formation. Activated carbon felt (ACF) electrodes were treated with 20% HNO3 for removing surface impurities and improving the surface area. The effect of the electrode modification was analyzed by performing various characterizations including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and cyclic voltammetry. The adsorption isotherm and kinetic models have also been studied. The effect of operating parameters including pH, voltage, initial concentration and time were analyzed and optimized using Box-Behnken design and were obtained as 6.42, 1.44 V, 0.50 mg/L and 131.51 min respectively. During the regeneration of electrodes, a concentrated cadmium solution of 18.55 mg/L was obtained, which showed the possibility of cadmium recovery. The maximum cadmium removal was 60.60% at the optimized conditions, revealing the significance of electrosorption for heavy metal treatment.
Mannose Conjugated Starch Nanoparticles for Preferential Targeting of Liver Cancer
Authors: Jain Akhlesh Kumar , Sahu Hitesh , Mishra Keerti , Thareja Suresh
Published: September 2020

Aim:

To design D-Mannose conjugated 5-Fluorouracil (5-FU) loaded Jackfruit Seed
Starch Nanoparticles (JFSSNPs) for site-specific delivery.

Background:

Liver cancer is the third leading cause of death in the world and the fifth most often
diagnosed cancer. It is a major global threat to public health. Treatment of liver cancer with conventional
method bears several side effects, thus to undertake these side effects as a formulation challenge,
it is necessary to develop novel target-specific drug delivery system for the effective and better
localization of drug into the proximity of target with restricting the movement of the drug in normal
tissues.

Objective:

To optimize and characterize the developed D-Mannose conjugated 5-Fluorouracil (5-
FU) loaded Jackfruit Seed Starch Nanoparticles (JFSSNPs) for effective treatment of liver cancer.

Materials and methods:

5-FU loaded JFSSNPs were prepared and optimized formulations having
higher encapsulation efficiency were conjugated with D-Mannose. These formulations were characterized
for size, morphology, zeta potential, X-Ray Diffraction, and Differential Scanning
Calorimetry. The potential of NPs was studied using in vitro cytotoxicity assay, in vivo kinetic
studies, and bio-distribution studies.

Results and Discussion:

5-Fluorouracil loaded NPs had a particle size between 336 to 802 nm with
drug entrapment efficiency between 64.2 to 82.3%. In XRD analysis, 5-FU peak was diminished in
the diffractogram, which could be attributed to the successful incorporation of the drug in amorphous
form. DSC study suggests there was no physical interaction between 5-FU and Polymer. NPs
showed sustained in vitro 5-FU release up to 2 hours. In vivo, mannose conjugated NPs prolonged
the plasma level of 5-FU and assisted in the selective accumulation of 5-FU in the liver (vs. other
organs spleen, kidney, lungs, and heart) compared to unconjugated one and plain drug.

Conclusion:

In vivo, bio-distribution, and plasma profile studies resulted in a significantly higher
concentration of 5-Fluorouracil liver, suggesting that these carriers are efficient, viable, and targeted
carrier of 5-FU treatment of liver cancer.
Should Percutaneous Coronary Intervention be the Standard Treatment Strategy for Significant Coronary Artery Disease in all Octogenarians?
Authors: Kassimis George , Karamasis Grigoris V. , Katsikis Athanasios , Abramik Joanna , Kontogiannis Nestoras , Didagelos Matthaios , Petroglou Dimitrios , Papadopoulos Christodoulos E. , Poulimenos Leonidas , Vassilikos Vassilios , Kanonidis Ioannis , Raina Tushar , Ziakas Antonios
Published: September 2020

Coronary artery disease (CAD) remains the leading cause of cardiovascular death in octogenarians.
This group of patients represents nearly a fifth of all patients treated with percutaneous
coronary intervention (PCI) in real-world practice. Octogenarians have multiple risk factors
for CAD and often greater myocardial ischemia than younger counterparts, with a potential of an increased
benefit from myocardial revascularization. Despite this, octogenarians are routinely under-
-treated and belittled in clinical trials. Age does make a difference to PCI outcomes in older people,
but it is never the sole arbiter of any clinical decision, whether in relation to the heart or any other
aspect of health. The decision when to perform revascularization in elderly patients and especially
in octogenarians is complex and should consider the patient on an individual basis, with clarification
of the goals of the therapy and the relative risks and benefits of performing the procedure. In
ST-segment elevation myocardial infarction (MI), there is no upper age limit regarding urgent
reperfusion and primary PCI must be the standard of care. In non-ST-segment elevation acute coronary
syndromes, a strict conservative strategy must be avoided; whereas the use of a routine invasive
strategy may reduce the occurrence of MI and the need for revascularization at follow-up, with
no established benefit in terms of mortality. In stable CAD patients, invasive therapy on top of optimal
medical therapy seems better in symptom relief and quality of life. This review summarizes
the available data on percutaneous revascularization in the elderly patients and particularly in octogenarians,
including practical considerations on PCI risk secondary to ageing physiology. We also
analyse technical difficulties met when considering PCI in this cohort and the ongoing need for further
studies to ameliorate risk stratification and eventually outcomes in these challenging patients.
Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration
Authors: Shafi Sadat , Singh Archu , Gupta Paras , Chawla Pooja A. , Fayaz Faizana , Sharma Anjali , Pottoo Faheem H.
Published: September 2020

Neurodegenerative diseases, including Alzheimer’s Disease (AD), Parkinson’s Disease
(PD), Amyotrophic Lateral Sclerosis (ALS) and Huntington's Disease (HD), are characterized by
progressive neuronal dysfunction and death. Recent studies have established detrimental modifications
in the structure and function of brain proteins, which stimulate their aggregation, misfolding
and deposition in and around the neurons an important hallmark of neurodegenerative diseases.
Post-Translational Modification (PTM) of proteins, including phosphorylation, acetylation, glycosylation,
palmitoylation, SUMOylation, and ubiquitination, are important regulators of protein characteristics,
including stability, intracellular distribution, activity, interactions, aggregation and clearance.
Despite clear evidence that altered protein modifications emerging from impromptu chemical
modifications to side chains of amino acid are associated with neurodegeneration, the underlying
mechanisms that promote aberrant PTM remain poorly understood. Therefore, elucidating PTM of
specific disease-associated proteins can prove to be a significant step in evaluating the functional alteration
of proteins and their association with neurodegeneration. This review describes how aberrant
PTM of various proteins is linked with the neurodegenerative disease pathogenesis, as well as
molecular strategies targeting these modifications for treating such diseases, which are yet incurable.
PREDLOG KVALITATIVNOG PREVAZILAŽENJA PROBLEMA KRHKIH DEMOKRATIJA
Authors: Milisavljevic Miljan
Published: September 2020

Rad predstavlja kritičku analizu stanja demokratija danas, posebno onih koje smo mi nazvali krhke demokratije. U prvom delu rada istakli smo najznačajnije karakteristike krhkih demokratija, kao i razloge njihovih slabih institucija. Kao najbitnija odlika, po našem mišljenju, je njihova politizacija. Takođe, utvrdili smo i sam izvor politizacije institucija, a koji se nalazi u političkim partijama. Pokazali smo da su one najvažniji politički akter u krhkim demokratijama, preko kojih politička elita ima kontrolu nad čitavim društvom. Na primerima učenja Simone Vej i Roberta Gudina pokazali smo dva dijametralno suprotna stava o ulozi partija u demokratskom društvu. Istakli smo da nedemokratsko delovanje partija u društvima krhkih demokratija dovodi do fenomena ”zarobljena država”. U drugom delu rada dali smo svoj predlog kvalitativnog prevazilaženja stanja u krhkim demokratijama. On bi se ogledao u tome da građani treba da na principima deliberativne demokratije prvo utvrde agendu prioritetnih problema koji opterećuju društva krhke demokratije, a onda i da daju predloge za njihovo rešavanje. Po našem mišljenju najbolji način da se to postigne bila bi istinska institucionalizacija deliberativne demokratije. Rad je teorijskog karaktera i blisko je povezan sa političkom teorijom, posebno iz oblasti konsolidacije demokratije. Kao glavne metode koriste se analiza sadržaja i komparativni metod.
KLJUČ ZA RAZUMEVANJE PREDDRŽAVNOG DRUŠTVA
Authors: Matic Ivan
Published: September 2020

Osvrt na knjigu:

Drevno društvo Luisa H. Morgana (Lewis H. Morgan, Ancient Society, Chicago: Kerr, 593 p.)
TRANSFORMACIONO/HARIZMATIČNO LIDERSTVO I MOTIVACIONA SPREMNOST SLEDBENIKA
Authors: Sladojevic-Matic Jelena , Opacic Goran
Published: September 2020

Bas (Bass, 1990) je predložio klasifikaciju stilova liderstva u okviru koje definiše transformaciono, transakciono i laisez-faire liderstvo (koje zapravo podrazumeva izostanak liderskog faktora). U ovom radu bavićemo se analizom transformacionog stila liderstva čija je osnovna karakteristika harizmatičan uticaj na sledbenike. Iz tog harizmatičnog uticaja proizilazi i visoka motivaciona spremnost sledbenika da autentično slede viziju transformacionog lidera. Istraživanja pokazuju da transformacioni stil liderstva visoko korelira sa motivacionom spremnošću sledbenika (Bovey & Hede, 2001).U radu ćemo takođe diskutovati principe etičkog liderstva (poštovanje sledbenika, služenje sledbenicima, princip pravičnosti, iskrenost u odnosu sa sledbenicima, uticaj na izgradnju i razvoj zajednice) i povezati primenu ovih principa sa karakteristikama transformacionog liderskog stila u koji su utkani upravo ovi navedeni principi liderske etičnosti. Motivaciona spremnost sledbenika odnosi se pre svega na otvorenost prema promenama i spremnosti na promene, što je u uslovima modernog poslovanja ali i u širem društvenom i socijalnom kontekstu preduslov razvoja svake organizacija ili sistema. Fokus rada je na dinamici razmene između lidera i sledbenika u cilju što efikasnije realizacije ciljeva uz uvažavanje etičkih principa liderstva. Pretpostavka je da uspostavljanje ovakve dinamike odnosa može imati pozitivan uticaj na sisteme i organizacije u kojima su lideri delatni ali i na širu društvenu zajednicu. Neki od faktora koje ćemo u radu diskutovati, značajno prevazilaze kontekst korporativnog funkcionisanja i mogu se istraživati i u okviru drugih društvenih i socijalnih organizacija i političkih stranaka.
Naturalismo y realismo en etnografía urbana. Cuestiones metodológicas para una antropología de las calles
Authors: Delgado Manuel
Published: September 2020

Establecer las bases para una etnografía de la calle como espacio social requiere un balance previo relativo a la vigencia de los modelos teóricos procurados por la tradición de la antropología social y a cuáles pueden ser los instrumentos de registro y descripción adecuados. En relación con esto último, el papel central que desempeñarían los estilos etológicos y no intrusivos de observación hace pertinente una reflexión sobre la necesidad de restaurar la predisposición naturalista en el trabajo de campo etnográfico, así como el protagonismo en cierto modo perdido de la descripción en los informes resultantes. Hablar de naturalismo supone, en este caso, no sólo evocar un cierto tipo de investigación científica; implica también solicitarle a la antropología que asuma como propia una cierta manera de mirar característica del naturalismo literario, pictórico o cinematográfico.
Trayectorias de los afrodescendientes en el comercio callejero de Bogotá
Authors: Meza Andrés
Published: September 2020

Este artículo reflexiona acerca de la yuxtaposición teórica entre el paradigma afrogenético y las aproximaciones posmodernas basadas en la teoría del mestizaje. Propone la complementariedad de ambos a partir del análisis de información histórica y etnográfica acopiada durante el trabajo de monografía con población afrodescendiente en Bogotá. Las dinámicas de la etnicidad y las relaciones interétnicas se abordan mediante el análisis de relatos de vida en los cuales los sujetos hablan de las experiencias migratorias, de la inserción urbana-metropolitana y, en especial, del trabajo en la venta ambulante. Se exponen, además, las vivencias particulares de los afrodescendientes como vendedores callejeros en el centro de la ciudad, correlacionándolas con la injerencia que tienen las políticas restrictivas de espacio público y ciertas prácticas discriminatorias y de estereotipia socio-racial.
El imaginario de una nación pluralista: los intelectuales públicos y la jurisdicción especial indígena en Colombia
Authors: Rappaport Joanne
Published: September 2020

La constitución de 1991 le da derecho a las comunidades indígenas a tener un sistema legal basado en sus propios “usos y costumbres”. El artículo explora el papel de los intelectuales indígenas en la reconstrucción del derecho consuetudinario, indagando cómo han interpretado los activistas indígenas el pluralismo legal al analizar el significado de los neologismos creados al traducir la constitución al idioma nasa. Luego analiza un caso legal en el que los derechos constitucionales de ciertos individuos como ciudadanos colombianos entran en conflicto con los derechos de las comunidades indígenas –recientemente reconocidos– como actores legales colectivos, tratando de entender los múltiples niveles en los que debe negociarse el pluralismo legal.
Penerapan Teknologi Produksi Benih Bawang Merah Varietas Lembah Palu Pada Kelompok Tani Bawang Di Desa Simoro.
Authors: Maemunah Maemunah , Adrianton Adrianton , Madauna I. , Yusran Yusran , Mustakim Mustakim
Published: September 2020

Produksi bawang merah Palu hanya sekitar 1028 – 1380 ton/tahun yang diperoleh dari luas areal tanam sekitar 290 hektar.  Produksi tersebut belum dapat memenuhi kebutuhan industri bawang goreng sekitar 1080 – 2160 ton. Rendahnya produksi diduga  sebagai akibat dari penggunaan benih  yang tidak bermutu.

Penyediaan benih bermutu tinggi hanya dapat diperoleh bila dilakukan penelitian dan pengkajian dan kemudian ditransfer serta dapat  diserap oleh Petani. Kegiatan ini dalam bentuk pendidikan dan pelatihan, introdusir teknologi dan pemberdayaan kelompok,berlansung selama lima bulan.

Kegiatan pengabdian bertujuan untuk mendampingi dan melatih petani dalam budidaya bawang merah untuk penyediaan benih bermutu secara berkelanjutan, sehingga dapat tersedia: tepat mutu, tepat jumlah dan tepat harga. Transfer teknologi produksi benih dilakukan pada Kelompok Tani Bawang merah di Desa Simoro Kecamatan Gumbasa, Kabupaten Sigi. Tim Peneliti dan Kelompok Tani  bersama-sama menerapkan  teknologi produksi dan pascapanen serta penyimpanan benih bawang yang terintegrasi  dalam budidaya bawang merah. Teknologi  yang diterapkan adalah inovasi teknologi produksi benih yang bersumber dari kearifan lokal masyarakat Petani bawang di Lembah Palu.
Aplikasi Pupuk Organik Diperkaya Pada Lahan Sawah Di Desa Bolapapu Kecamatan Kulawi Kabupaten Sigi
Authors: Widjajanto Danang , Hasanah Uswah , Sukmawati St. , Sufyan Sufyan , Mukmin Mukmin , Sari Nurvita , R. Handayani Sy Mufida
Published: September 2020

Tujuan kegiatan adalah :  1)  mengidentifikasi kualitas pupuk organik yang diperkaya dengan bahan-bahan lokal,  2) menentukan pengaruh pupuk organik diperkaya terhadap beberapa sifat fisik tanah, pertumbuhan dan hasil padi, 3)  mengidentifikasi beberapa faktor dominan yang mempengaruhi kinerja kegiatan kelompok tani mitra. Kegiatan dilaksanakan  di Desa Bolapapu, Kecamatan Kulawi, Kabupaten Sigi menggunakan  metode penyuluhan, demonstrasi plot percobaan,  dan diskusi kelompok terfokus.  Hasil analisis beberapa kandungan pupuk organik yang dihasilkan mitra telah memenuhi kriteria baku mutu produk nasional, Pengggunaan pupuk organik di lapang menunjukkan pengaruh nyata terhadap beberapa sifat fisik tanah, pertumbuhan dan hasil tanaman padi.  Faktor-faktor dominan yang mempengaruhi kinerja kelompok tani mitra adalah pengalaman berusaha tani, luas lahan garapan dan besarnya pendapatan petani.
Psychosocial Moderators of the Impact of Diabetes Stigma: Results From the Second Diabetes MILES – Australia (MILES-2) Study
Authors: Holmes-Truscott Elizabeth , Ventura Adriana D. , Thuraisingam Sharmala , Pouwer Frans , Speight Jane
Published: September 2020

OBJECTIVE

To examine the association of diabetes stigma with psychological, behavioral, and HbA1c outcomes and to investigate moderation effects of self-esteem, self-efficacy, and/or social support.

RESEARCH DESIGN AND METHODS

The national Second Diabetes MILES – Australia (MILES-2) survey included adults with type 1 diabetes (n = 959, 41% of whom were male, with mean ± SD age 44 ± 15 years), insulin-treated type 2 diabetes (n = 487, 60% male, age 61 ± 9 years), and non–insulin-treated type 2 diabetes (n = 642, 55% male, age 61 ± 10 years). (Un)adjusted linear regression analyses tested the association between diabetes stigma (Diabetes Stigma Assessment Scale [DSAS]) and psychological outcomes (depressive symptoms [eight-item version of the Patient Health Questionnaire (PHQ-8)], anxiety symptoms [Generalized Anxiety Disorder 7-item (GAD-7) questionnaire], and diabetes-specific distress [20-item Problem Areas In Diabetes (PAID) scale]), behavioral outcomes (healthy diet and physical activity [Summary of Diabetes Self-Care Activities (SDSCA)]), and self-reported HbA1c. Interaction effects tested whether associations varied by self-esteem (Rosenberg Self-Esteem Scale [RSES]), self-efficacy (Confidence in Diabetes Self-Care [CIDS] scale), or diabetes-specific social support (Diabetes Support Scale [DSS]).

RESULTS

Significant positive associations were observed between DSAS and PHQ-8, GAD-7, and PAID across diabetes type/treatment groups (all P < 0.001), whereby each SD increase in DSAS scores was associated with approximately one-half SD deterioration in emotional well-being. Associations between DSAS and SDSCA and HbA1c were nonmeaningful. Self-esteem moderated psychological outcomes among participants with type 1 and non–insulin-treated type 2 diabetes and diabetes distress among those with insulin-treated type 2 diabetes. Interaction effects were partially observed for social support but not for self-efficacy.

CONCLUSIONS

This study provides evidence of the association between diabetes stigma and depressive/anxiety symptoms and diabetes distress and for the moderating effects of self-esteem and social support among adults with type 1 and type 2 diabetes. Further research is needed to examine associations with objectively measured behavioral and clinical outcomes.
Improved Time in Range Over 1 Year Is Associated With Reduced Albuminuria in Individuals With Sensor-Augmented Insulin Pump–Treated Type 1 Diabetes
Authors: Ranjan Ajenthen G. , Rosenlund Signe V. , Hansen Tine W. , Rossing Peter , Andersen Steen , Nørgaard Kirsten
Published: September 2020

OBJECTIVE

To investigate the association between treatment-induced change in continuous glucose monitoring (CGM) time in range (TIR) and albuminuria in persons with type 1 diabetes (T1D) treated with sensor-augmented insulin pumps (SAP).

RESEARCH DESIGN AND METHODS

Twenty-six out of 55 participants with albuminuria and multiple daily injection therapy (25% females; median 51 [interquartile range 46–63] years of age; glycated hemoglobin A1c (HbA1c) 75 [68–88] mmol/mol [9.0% (8.4–10.4%)]; and urinary albumin-to-creatinine ratio (UACR) 89 [37–250] mg/g) were in a randomized controlled trial assigned to SAP therapy for 1 year. Anthropometrics, CGM data, and blood and urine samples were collected every 3 months.

RESULTS

Mean change (95% CI) in percentage of TIR (%TIR) was 13.2% (6.2; 20.2), in HbA1c was −14.4 (−17.4; −10.5) mmol/mol (−1.3% [−1.6; −1.0]), and in UACR was −15% (−38; 17) (all P < 0.05). UACR decreased by 19% (10; 28) per 10% increase in %TIR (P = 0.04), 18% (1; 30) per 10 mmol/mol decrease in HbA1c (P = 0.07), and 31% per 10-mmHg decrease in mean arterial pressure (P < 0.001).

CONCLUSIONS

In this longitudinal study, treatment-induced increase in %TIR was significantly associated with decrease in albuminuria in T1D.
Impact of Quality Improvement (QI) Program on 5-year Risk of Diabetes-related Complications: a Simulation Study
Authors: Shao Hui , Fonseca Vivian , Furman Roy , Meneghini Luigi , Shi Lizheng
Published: September 2020

Objective

We successfully implemented the ADA’s Diabetes INSIDE®
quality improvement program at a University hospital and safety-net health
system (Tulane and Parkland), focused on system-wide improvement in poorly
controlled type 2 diabetes (HbA1c>8.0% [64 mmol/mol]). In this study, we estimated
the 5-year risk reduction in complications and mortality associated with the QI
program.

Research Design and Methods

The QI implementation period was one year, followed by
the post-intervention period of six months to evaluate the impact of QI on
clinical measures. We measured the differences between the baseline and
post-intervention clinical outcomes in 2,429 individuals with HbA1c >8% (64
mmol/mol) at baseline and used the Building, Relating, Assessing,
Validating Outcomes (BRAVO™) of diabetes
model to project the 5-year risk reduction of diabetes-related complications
under the assumption that intervention benefits persist over time. An
alternative assumption that intervention benefits diminish by 30%
every year was also tested.

Results

The QI program was associated with reductions in HbA1c
(-0.84%) and LDL-C (-5.94 mg/dl) among individuals with HbA1c level >8.0%
(64 mmol/mol), with greater reduction in HbA1c (-1.67%) and LDL-C (-6.81 mg/dl)
among those with HbA1c level > 9.5% at baseline (all p<0.05). The
implementation of the Diabetes INSIDE® QI program was associated
with 5-year risk reductions in major adverse cardiovascular events (MACE,
Relative Risk (RR): 0.78, 95% confidence interval (CI):0.75-0.81) and all-cause
mortality (RR:0.83, 95% CI: 0.82-0.85) among individuals with baseline HbA1c
level >8.0% (64 mmol/mol), and MACE (RR: 0.60, 95% CI:0.56-0.65) and
all-cause mortality (RR: 0.61, 95% CI: 0.59-0.64) among individuals with
baseline HbA1c level > 9.5% (80 mmol/mol). Sensitivity analysis also identified
a substantially lower risk of diabetes-related complications and mortality associated
with the QI program.

Conclusions

Our modeling results suggest that the ADA’s Diabetes
INSIDE® QI program would benefit the patients and population by
substantially reducing the 5-year risk of complications and mortality in
individuals with diabetes.
Patients with type 2 diabetes have an increased demand for pacemaker treatment - a comparison with age- and sex matched controls from the general population.
Authors: Rautio Elina , Gadler Fredrik , Gudbjörnsdottir Soffia , Franzén Stefan , Rydén Lars , Svensson Ann-Marie , Mellbin Linda G
Published: September 2020

Objective: Patients
with type 2 diabetes mellitus have an increased risk for cardiovascular disease
including arrhythmias. The prevalence of bradyarrhythmia and the subsequent
need for treatment with pacemakers (PM) is less well explored in a contemporary
patient population. The present
study explores 1) whether patients with type 2 diabetes mellitus have an
increased demand for PM implantation compared with an age- and sex-matched
control population without diabetes mellitus; 2) Patient characteristics
associated with increased demand of receiving a PM.

Methods:
In this population-matched registry study a total of 416 247 patients with
type 2 diabetes mellitus from the Swedish National Diabetes Registry (NDR) and 2 081
235 age and sex-matched controls selected from the general population were included between 1 January 1998 and 31 December 2012
and followed until 31 December 2013. Mean follow-up time was 7 years. Cox’s
proportional hazard regression analyses were performed to estimate the demand
of PM-treatment and factors identifying patients with such demand.

Results:
Type 2
diabetes mellitus was associated with increased need of PM-treatment (Hazard
ratio (HR) 1.65, 95% CI 1.60-1.69;
p<0.0001) which remained (HR 1.56, 95% CI
1.51-1.60; p<0.0001) after adjustments for age,
sex, educational level, marital status, country of birth and coronary heart
disease. Risk factors for receiving a PM included
increasing age, HbA1c, BMI, diabetes duration, blood pressure- and lipid
lowering medication.

Conclusion: The need for PM treatment is higher in patients
with type 2 diabetes than in matched population-based controls. Age, diabetes duration
and HbA1c seem to be risk factors for PM treatment.
Mechanisms underlying absent training-induced improvement in insulin action in lean, hyperandrogenic women with polycystic ovary syndrome (PCOS)
Authors: Admin Ada , Hansen Solvejg L. , Bojsen-Møller Kirstine N. , Lundsgaard Anne-Marie , Hendrich Frederikke L. , Nilas Lisbeth , Sjøberg Kim A. , Hingst Janne R. , Serup Annette K. , Henríquez-Olguín Carlos , Carl Christian S. , Wernblad Louise F. , Henneberg Marie , Lustrup Katja M. , Hansen Christine , Jensen Thomas E. , Madsbad Sten , Wojtaszewski Jørgen F.P. , Richter Erik A. , Kiens Bente
Published: September 2020

Women
with polycystic ovary syndrome (PCOS) have been shown to be less insulin
sensitive compared with control women, independent of BMI. Training is
associated with molecular adaptations in skeletal muscle improving glucose uptake
and metabolism in both healthy and type 2 diabetic individuals. In the present
study, lean, hyperandrogenic women with PCOS (n=9) and healthy controls (CON, n=9)
completed 14 weeks of controlled and supervised exercise training. In CON, the
training intervention increased whole
body insulin action
by 26% and
insulin-stimulated leg glucose uptake by 53%, together with increased
insulin-stimulated leg blood flow and a more oxidative muscle fiber type distribution.
In PCOS, no such changes were found, despite similar training intensity and
improvements in maximal oxygen uptake. In skeletal muscle of CON, but not PCOS,
training increased GLUT4 and HKII mRNA and protein expressions. These data suggest that the
impaired increase in whole body insulin action in women with PCOS with training
is caused by an impaired ability to upregulate key glucose handling
proteins for insulin-stimulated glucose uptake in skeletal muscle, and insulin-stimulated
leg blood flow. Still, other
important benefits of exercise training appeared in women with PCOS, including an
improvement of the hyperandrogenic state.
Propuesta de actualización de saberes en campos numéricos para estudiantes de pedagogía en telesecundaria
Authors: Gómez Segura Enrique
Published: September 2020

El presente artículo muestra una secuencia didáctica dirigida a los estudiantes de la licenciatura en Enseñanza y Aprendizaje en Telesecundaria de la Escuela Normal Urbana Federal Prof. Rafael Ramírez de Chilpancingo, Guerrero, con la finalidad de sistematizar sus conocimientos en los diversos campos numéricos. El objetivo es conocer y manejar la clasificación de los números reales, porque es de suma importancia para los docentes en formación: si saben las características de cada uno de ellos, podrán realizar las operaciones adecuadas, sin confundirse entre los diversos campos numéricos. El presente trabajo se fundamenta en la teoría de David Ausubel (Méndez, 1993), que trata sobre el aprendizaje significativo. Por otra parte, es muy común que los estudiantes de secundaria confundan las reglas de operación que se aplican en la suma y resta, y las utilicen para multiplicar y dividir; esto tiene una explicación, los conocimientos matemáticos son como una espiral, cada vez se van incrementando y las reglas van cambiando, por eso cada campo numérico nuevo representa para el alumno un conflicto cognitivo, de tal manera que no es la misma regla sumar dos números positivos que sumar dos fracciones que tienen diferente denominador. El resultado de la suma de dos números enteros positivos también es positivo y es mayor que cualquier sumando; mientras que la suma de las fracciones tiene otro procedimiento muy distinto; en este caso, se ocupó el mínimo común múltiplo y las fracciones equivalentes para calcular la suma. Lo mismo sucede con los demás campos numéricos.
Identidad del sujeto educativo en la narrativa de la responsabilidad social universitaria
Authors: Castillejos Solís María Eugenia
Published: September 2020

A cuenta de los contenidos del programa interinstitucional de responsabilidad social universitaria (RSU) de las instituciones de educación superior mexicanas, se busca reflexionar en el campo fenoménico de la construcción de las identidades de los universitarios como el lugar de articulación intersubjetiva y simbólica desde donde los proyectos profesionales devienen proyectos ciudadanos. Esta articulación se revisa aquí con los significados del sujeto, la moral y la ética para una cultura política contemporánea ausente y sin embargo necesaria para configurar el telón de fondo de algunas de las narrativas de la universidad como institución de y entre la vida pública. Se ha asumido levantar y transitar por un andamiaje de la filosofía hermenéutica de Paul Ricoeur hacia el campo de la antropología filosófica y la política social. El análisis queda orientado por la teoría de la identidad narrativa (Ricoeur) que apertura el espacio ontológico del cuidado, la estima y el respeto de sí que vigoriza el lugar desde donde se afirman los valores identitarios de la RSU para la vida democrática de las instituciones de educación superior.
Autonomia do trabalho do supervisor de ensino
Authors: Ribeiro Elidia Vicentina de Jesus , Marques Silvio César Moral
Published: September 2020

Este artigo teve como objetivo discutir as percepções do supervisor de ensino e sua atuação junto às escolas e às Diretorias de Ensino a partir dos conceitos de trabalho e autonomia. Tratou-se de uma pesquisa exploratória, de cunho qualitativo com a participação de 14 respondentes, supervisores da Região de Itapetininga-SP, por meio de questionários semiestruturado e entrevista a Dirigente Regional. As devolutivas dos respondentes revelaram que a autonomia do supervisor de ensino é um elemento de caráter relativo, por conta do direcionamento a que está sujeito pelos condicionantes do trabalho que exerce. No entanto, o caráter criativo das possibilidades de implementação e construção de sua práxis visa à emancipação de sujeitos, em função da necessidade do fortalecimento da coletividade e ações entre os profissionais da escola, vivienciadas pela articulação do seu trabalho na Diretoria de Ensino, com seus pares e com as equipes de apoio e direção do Dirigente Regional.