bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Efficacy of Pimobendan Versus Benazepril for the Treatment of Acquired Atrioventricular Valvular Disease in Dogs
Authors: Lombard Christophe W. , Jöns Olaf , Bussadori Claudio M.
Published: September 2014

Seventy-six dogs with clinical acquired atrioventricular valvular disease were evaluated to determine the efficacy of pimobendan (n=41) versus benazepril hydrochloride (n=35) in a randomized, positive-controlled, multicenter study. The study was divided into 56-day and long-term evaluation periods. In a subgroup of dogs with concurrent furosemide treatment (pimobendan [n=31], benazepril [n=25]), the Heart Insufficiency Score improved in favor of pimobendan (P=0.0011), equating to a superior overall efficacy rating (P<0.0001) at day 56. Long-term median survival (i.e., death or treatment failure) for dogs receiving pimobendan was 415 days versus 128 days for dogs not on pimobendan (P=0.0022).
Comparison of Acute Hemodynamic Effects of Lidocaine and Procainamide for Postoperative Ventricular Arrhythmias in Dogs
Authors: Chandler John C. , Monnet Eric , Staatz Andrew J.
Published: September 2014

Heart rate and systolic, diastolic, and mean pressures were measured in two groups of dogs during treatment of postoperative ventricular arrhythmias either with intravenous (IV) 2% lidocaine hydrochloride or procainamide hydrochloride. Hemodynamic parameters were not significantly changed after IV administration of either drug. Additionally, changes in hemodynamic parameters for dogs treated with 2% lidocaine were not significantly different from those of dogs treated with procainamide. When dosed appropriately in the clinical setting, one bolus of IV procainamide was safe for the treatment of postoperative ventricular arrhythmias.
Long-Term Efficacy of Trilostane Administered Twice Daily in Dogs With Pituitary-Dependent Hyperadrenocorticism
Authors: Alenza Dolores Perez , Arenas Carolina , Lopez Mari Luz , Melian Carlos
Published: September 2014

Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.
Gallbladder Agenesis in a Maltese Dog
Authors: Austin Brenda , Tillson D. Michael , Kuhnt Leah Ann
Published: September 2014

This report describes the diagnostic evaluation of a 7-month-old, female Maltese dog with elevated liver enzymes. Marked elevations of alanine transferase were the significant clinical findings. A diagnosis of gallbladder agenesis was made, based on lack of a gallbladder on ultrasonography and on surgical exploration. Gallbladder agenesis is a rare condition described in humans but not previously reported in dogs.
Treatment of Severe Adverse Cutaneous Drug Reactions With Human Intravenous Immunoglobulin in Two Dogs
Authors: Trotman Tara K. , Phillips Heidi , Fordyce Hilary , King Lesley G. , Morris Daniel O. , Giger Urs
Published: September 2014

Severe adverse cutaneous reactions were documented in two dogs with acute skin lesions and systemic signs after exposure to several oral and injectable drugs. Because of the high morbidity and mortality rates of many severe cutaneous drug reactions and a poor response to supportive care, wound management, and conventional immunosuppressive therapy, human intravenous immunoglobulin (IVIG) was infused on 2 consecutive days (1 g/kg per day) after informed consent was received. Human IVIG, with supportive care, resulted in rapid resolution of dermatological and systemic signs in both dogs; this treatment may be considered in other cases of severe cutaneous drug reactions.
Cardiovascular Dysfunction in Dogs Associated With Critical Illnesses
Authors: Nelson O. Lynne , Thompson Pam A.
Published: September 2014

The records of 16 dogs with left ventricular dysfunction associated with severe systemic illness were reviewed. The most common diagnoses in affected dogs were sepsis and cancer. Despite left ventricular dysfunction, no dog presented with signs of congestive heart failure. Fifteen dogs were presented with generalized weakness as a part of their clinical complaint. Twelve (75%) of 16 dogs died or were euthanized within 15 days of admission to the hospital. The average time until death was 3.6 days.
Combined Use of Surgery and Radiation in the Treatment of an Intradural Myxoid Liposarcoma in a Dog
Authors: Rodenas Sergio , Valin Isabel , Devauchelle Patrick , Delisle Françoise , Baron Michel
Published: September 2014

An intradural-extramedullary myxoid liposarcoma of the high cervical spine was diagnosed in a 9-year-old, spayed female Cavalier King Charles spaniel that was presented for a 2-month history of cervical pain and tetraparesis. Radiation therapy applied after surgery resulted in complete remission of the neurological deficits. The tumor recurred 18 months after surgical excision. A second surgery and another course of radiotherapy again resulted in complete remission of the clinical signs. The dog was euthanized 11 months after the second surgery because of tumor recurrence.
Radiation Therapy for Incompletely Excised Grade II Canine Mast Cell Tumors
Authors: Poirier Valerie Jasmine , Adams William M. , Forrest Lisa J. , Green Eric M. , Dubielzig Richard R. , Vail David M.
Published: September 2014

Forty-five dogs with incompletely excised grade II mast cell tumors were treated with radiation using a cobalt 60 teletherapy unit (15 fractions of 3.2 Gy for a total of 48 Gy). Twenty-four of the dogs underwent prophylactic regional lymph node irradiation. Three (6.7%) dogs had tumor recurrence, two (4.4%) dogs developed metastasis, and 14 (31%) dogs developed a second cutaneous mast cell tumor. No difference in overall survival rate was observed between the dogs receiving and not receiving prophylactic irradiation of the regional lymph node.
Aftershocks of Cancer Chemotherapy: Managing Adverse Effects
Authors: Thamm Douglas H. , Vail David M.
Published: September 2014

Most cytotoxic chemotherapy protocols used in small animals are designed to have a low risk of adverse effects; however, adverse events can occasionally occur. Timely and appropriate management of adverse events greatly increases client satisfaction and the likelihood of a successful treatment outcome. This article presents guidelines for the management of chemotherapy-associated hematological and gastrointestinal disturbances, extravasation injury, and anaphylaxis.
Surveillance of Infections Associated With Intravenous Catheters in Dogs and Cats in an Intensive Care Unit
Authors: Marsh-Ng Michelle L. , Burney Derek P. , Garcia Jennifer
Published: September 2014

Positive catheter-tip culture rates and risk factors associated with bacterial colonization of intravenous (IV) catheters were assessed in dogs and cats. Aerobic and anaerobic bacterial cultures were performed on 151 catheters, and 24.5% were positive. Of the positive cultures, 46.0% grew Enterobacter spp. The type of catheter used, blood sampling through the catheter, the type of IV infusate administered, the duration the catheter was in place, the catheter location, complications with the catheter, and the final outcome of the animal were not associated with an increased risk of a positive bacterial culture from the catheter tip.
Unusual Case of Osteopenia Associated With Nutritional Calcium and Vitamin D Deficiency in an Adult Dog
Authors: de Fornel-Thibaud Pauline , Blanchard Géraldine , Escoffier-Chateau Laurence , Segond Sophie , Guetta Franck , Begon Dominique , Delisle Françoise , Rosenberg Dan
Published: September 2014

A 6-year-old, spayed female rottweiler was presented for facial enlargement from swelling of the maxilla and mandible. The dog was fed a homemade diet deficient in calcium and vitamin D, suggesting that rubber jaw syndrome was a secondary nutritional disorder. Radiographic and tomodensitometric examinations revealed diffuse bone resorption in the skull. The plasma parathormone concentration was high, and serum 25-hydroxycholecalciferol concentration was low. Based on these findings, nutritional calcium and vitamin D deficiency associated with secondary hyperparathyroidism was diagnosed. Dietary correction resulted in clinical and biological improvement, with an increase in skull mineralization.
Antibiotic-Resistant Corynebacterium jeikeium Urinary Tract Infection in a Cat
Authors: Puskar Michelle , Lemons Carol , Papich Mark G. , Vaden Shelley L. , Birkenheuer Adam
Published: September 2014

A 10-year-old, castrated male, domestic longhaired cat with a history of urinary tract disease and perineal urethrostomy was presented for evaluation of persistent urinary tract inflammation. Prior to referral, diphtheroid organisms had been cultured from a urine sample obtained by cystocentesis, and they were interpreted as sample contamination. Subsequent urine culture and gene sequencing identified Corynebacterium jeikeium, which was resistant to antibiotics and appeared to be the cause of the urinary tract infection.
Insulinoma in a Dog With Pre-existing Insulin-Dependent Diabetes Mellitus
Authors: Bryson Elizabeth R. , Snead Elisabeth C.R. , McMillan Chantal , MacDougall Lori , Allen Andrew L.
Published: September 2014

A 10-year-old golden retriever with a 3-year history of insulin-dependent diabetes mellitus was presented with recurring episodes of hypoglycemia and seizures. A presumptive diagnosis of an insulinoma was made based on hypoglycemia with concurrent endogenous hyperinsulinemia and unremarkable radiographic and ultrasonographic images of the chest and abdomen. A beta cell carcinoma of the pancreas with metastasis to the liver and a mesenteric lymph node was confirmed by surgery and histopathology.
Giant Hypertrophic Gastritis (Ménétrier’s-like Disease) in an Old English Sheepdog
Authors: Rallis Tim S. , Patsikas Michael N. , Mylonakis Mathios E. , Day Michael J. , Petanides Theodoros A. , Papazoglou Lysimachos G. , Koutinas Alexander F.
Published: September 2014

An 11-year-old, male Old English sheepdog was admitted for weight loss and intermittent vomiting of 1 month’s duration. A cranioventral abdominal mass, anemia, hypoproteinemia, and hypoalbuminemia were the prominent abnormal findings. Imaging studies identified a remarkably thickened gastric wall with multilobulated folds protruding into the gastric lumen. Gastrotomy revealed the presence of giant cerebriform rugal folds arising from the fundus and body of the stomach. Pronounced gastric glandular hyperplasia and lack of evidence of cellular atypia were suggestive of giant hypertrophic gastritis. The dog was treated with prednisolone, cimetidine, and hyoscine butylbromide, only to experience a short-term remission.
Surgical Correction of Colonic Duplication in a Cat
Authors: Kramer Alon , Kyles Andrew E. , Labelle Philippe
Published: September 2014

A 2-year-old, castrated male Manx cat was presented for anorexia, obstipation, and straining to defecate. Imaging tests revealed a cystic mass associated with the descending colon. Three surgical explorations over several years were performed before complete resection of the cystic mass was achieved. Histopathology of the mass revealed normal colonic structures consistent with colonic duplication. Complete resection of a noncommunicating duplicate colon may allow successful treatment of this condition and resolution of associated clinical signs.
Retrospective Study of Tetanus in 20 Dogs: 1988–2004
Authors: Bandt Carsten , Rozanski Elizabeth A. , Steinberg Tanja , Shaw Scott P.
Published: September 2014

The case records of 20 dogs that were treated for tetanus between 1988 and 2004 were reviewed. Young, large-breed dogs were most commonly affected. Twelve dogs had a likely source of infection identified. All dogs were treated with intravenous antibiotics and supportive care, such as muscle relaxants and sedation for muscle tremors and rigidity. Sixteen dogs received tetanus antitoxin. The mortality rate was 50%. Complete recovery in survivors required approximately 1 month.
Refractory Seizures Associated With an Organic Aciduria in a Dog
Authors: Platt Simon , McGrotty Yvonne L. , Abramson Carley J. , Jakobs Cornelis
Published: September 2014

A 6-month-old, female Cavalier King Charles spaniel exhibited seizures that were difficult to control with standard anticonvulsants over a 12-month period. The diagnosis of an organic aciduria with excessive excretion of hexanoylglycine was determined when the dog was 20 months old. Recurrent and cluster seizures were eventually controlled with the addition of levetiracetam to potassium bromide and phenobarbital.
Organic Diseases Mimicking Acral Lick Dermatitis in Six Dogs
Authors: Denerolle Philippe , White Stephen D. , Taylor Tara S. , Vandenabeele Sophie I.J.
Published: September 2014

Acral lick dermatitis (“lick granuloma”) in dogs is often thought to have a behavioral etiology. However, other diseases may cause lesions on the distal legs, mimicking acral lick dermatitis. In this report, six dogs were presented with acral lick dermatitis-like lesions from different underlying causes—namely lymphoma, an orthopedic pin, deep pyoderma, mast cell tumor, leishmaniasis, and (presumptive) sporotrichosis.
AAHA/AAFP Pain Management Guidelines for Dogs & Cats
Authors: Hellyer Peter , Rodan Ilona , Brunt Jane , Downing Robin , Hagedorn James E. , Robertson Sheilah Ann
Published: September 2014

Pain management in dogs and cats has undergone a dramatic evolution in the past decade. Current approaches focus on anticipation and prevention of pain, as well as both pharmacologic and nonpharmacologic management techniques. The veterinary team plays an essential role in educating pet owners about recognizing and managing pain in their pets.
Plasma Concentrations of Lidocaine in Dogs Following Lidocaine Patch Application
Authors: Ko Jeff , Weil Ann , Maxwell Lara , Kitao Takashi , Haydon Todd
Published: September 2014

Transdermal absorption of lidocaine was determined by measuring plasma lidocaine concentrations following skin application of 5% lidocaine patches. Two lidocaine patches were placed on the ventral abdominal midline of seven dogs for 72 hours. Lidocaine was detectable in plasma 12 hours after patch application, and it reached steady-state concentrations between 24 and 48 hours. Plasma lidocaine levels decreased dramatically at 60 hours post-application. Low plasma lidocaine concentrations remained for 6 hours after patch removal. No clinically significant side effects were noted.
Teratoma in the Cervical Spinal Cord of a Dog
Authors: Wong Michael A. , Mariani Christopher L. , Powe Joshua R. , Clemmons Roger M.
Published: September 2014

An 11-year-old, spayed female giant schnauzer was presented for evaluation of chronic, progressive tetraparesis. Diagnostic imaging was consistent with intervertebral disk protrusion, and surgical decompression and stabilization were performed. Postoperatively the dog did not improve, and further imaging suggested an intramedullary mass at the level of the sixth cervical vertebra. The dog was euthanized 7 days after surgery, and a teratoma was found postmortem.
Safety and Feasibility of Transesophageal Pacing in a Dog
Authors: Schmidt Mandi , Estrada Amara , VanGilder Jim , Maisenbacher Herbert , Prosek Robert
Published: September 2014

This study investigated the feasibility of using a modified transesophageal atrial pacing system for dogs requiring temporary ventricular pacing. Atrial pacing was readily achieved in the one dog studied, but it caused considerable diaphragmatic movement. Ventricular pacing could not be achieved at any lead configuration or energy stimulation. While transesophageal cardiac pacing was a safe procedure, the large variation in the chest anatomy of dogs requires further study to explore this model as a substitute for transvenous or transthoracic ventricular pacing.
Aplastic Anemia in Two Kittens Following a Prescription Error
Authors: Paul April L. , Shaw Scott P. , Bandt Carsten
Published: September 2014

A medication error resulted in two kittens being treated with azathioprine (12 and 12.5 mg/kg) instead of azithromycin for 2 weeks. On clinical examination, the kittens were febrile, weak, and had oronasal hemorrhage. Complete blood cell counts indicated severe bone marrow suppression. Treatment consisted of multiple transfusions, antibiotics, and granulocyte colony-stimulating factor. One of the kittens responded to therapy and had a complete recovery. The other kitten was treated for 40 days with no clinical response before dying. Both kittens also contracted Mycoplasma hemofelis infection from a contaminated blood transfusion.
Prostatic Abscess in a Neutered Cat
Authors: Mordecai Adam , Liptak Julius M. , Hofstede Tamara , Stalker Margaret , Kruth Stephen
Published: September 2014

A 6-year-old, male castrated domestic shorthair cat was presented for evaluation of lethargy, vomiting, anorexia, and constipation. Physical examination revealed an elevated body temperature and an extramural colonic mass. Abdominal ultrasonography demonstrated a hypoechoic mass measuring 2.2 cm in maximum dimension immediately caudal to the bladder. Cytological evaluation of a fine-needle aspirate confirmed the mass was a prostatic abscess. Abdominal celiotomy and prostatic omentalization were successful in resolving clinical abnormalities. Feline prostatic abscessation is a rare condition that has not been previously reported and may have a good outcome if treated early and appropriately.
Pseudothrombocytopenia Secondary to the Effects of EDTA in a Dog
Authors: Wills Tamara B. , Wardrop K. Jane
Published: September 2014

Pseudothrombocytopenia (PTCP) secondary to the effects of ethylenediaminetetraacetic acid (EDTA) has been noted in horses and pigs and should be considered in dogs with moderate thrombocytopenia and no clinical bleeding tendency. This type of pseudothrombocytopenia is not a pathological process by itself, but it can be clinically significant if diagnostics and medical treatments are initiated based on the reported thrombocytopenia. Platelet clumping occurs with EDTA-dependent PTCP, resulting in inaccurate hematology analyzer platelet concentrations. A nontraumatic venipuncture may be sufficient to obtain an accurate platelet count. However, rare cases in the dog may require blood drawn into a different anticoagulant, such as sodium citrate, to help discriminate a true thrombocytopenia from PTCP.
Pancreatic Abscess in 36 Dogs: A Retrospective Analysis of Prognostic Indicators
Authors: Anderson Jonathan R. , Cornell Karen K. , Parnell Nolie K. , Salisbury S. Kathleen
Published: September 2014

Thirty-six dogs were diagnosed with pancreatic abscess by the presence of purulent exudate within the parenchyma of the pancreas during exploratory laparotomy. Data regarding history, physical examination findings, clinicopathological data, diagnostic imaging findings, bacteriological culture results, abdominal drainage technique, and perioperative treatment were evaluated for factors predictive of survival. Elevated blood urea nitrogen, serum alkaline phosphatase activity, and rising bicarbonate ion concentration were each found to have statistically significant (P<0.05) influences on survival to discharge. Twenty-two (71%) of 36 dogs died or were euthanized prior to discharge from the hospital.
Evaluation of Two Methods of Endotracheal Tube Selection in Dogs
Authors: Lish Jim , Ko Jeff C. H. , Payton Mark E.
Published: September 2014

This study evaluated two methods of endotracheal tube selection using 28 fresh canine carcasses of various ages, weights, and genders. The two selection methods were 1) nasal septal width pairing with outer diameter of an endotracheal tube, and 2) digital palpation of the tracheal outer diameter to determine the endotracheal tube size. All dogs were dolichocephalic breeds. Results of this study showed that the canine nasal septal width method of endotracheal tube selection was correlated with the size of the tracheal internal (r=0.72) and outer (r=0.73) diameters. However, evidence shows that the digital palpation method is slightly more effective than the nasal width method in selecting the best-fitting endotracheal tube. The percentage of the best-fit tube selection for the nasal septal width method was 21%, while the digital palpation method was 46%. With these two methods, selecting an endotracheal tube that is too small is possible, especially when the tube internal diameter is ≥7 mm.
Use of Recombinant Human Interferon Alpha-2a in the Management of a Dog With Epitheliotropic Lymphoma
Authors: Tzannes Sophia , Ibarrola Patricia , Batchelor Daniel J. , Burrow Rachel D. , Blackwood Laura
Published: September 2014

An 8-year-old, mixed-breed dog with preputial epitheliotropic lymphoma was initially treated with cyclophosphamide, vincristine, and prednisolone. A short-term partial response was followed by disease progression after 4 weeks. Recombinant human interferon alpha-2a was administered starting at week 7. The interferon therapy resulted in rapid resolution of clinical signs and a 10-week disease-free interval. The lymphoma recurred at 17 weeks and did not respond to rescue chemotherapy. Additional oral lesions were treated with localized radiotherapy followed by increased dosages of interferon. This additional interferon treatment resulted in another 12 weeks of stable disease.
Exercise-Induced Collapse of Labrador Retrievers: Survey Results and Preliminary Investigation of Heritability
Authors: Taylor Susan M. , Shmon Cindy L. , Shelton G. Diane , Patterson Edward (Ned) E. , Minor Katie , Mickelson James R.
Published: September 2014

Completed surveys were obtained from owners of 225 Labrador retrievers affected by the syndrome of exercise-induced collapse. Questions addressed signalment, age of onset, description of collapse episodes, and owner perception of activities and factors associated with collapse. Most dogs were young (mean 12 months) when collapse episodes began. Retrieving was the activity most commonly associated with collapse. Owners felt that excitement (187/225; 83%) and high environmental temperatures (71/225; 31%) increased the likelihood of collapse. Analysis of pedigrees collected from 169 affected dogs was most consistent with an autosomal recessive mode of inheritance.
Hypertrophic Osteodystrophy of the Proximal Humerus in Two Dogs
Authors: Franklin Michelle A. , Rochat Mark C. , Broaddus Kristyn D.
Published: September 2014

Two dogs, 3 and 6 months of age, were presented with painful, swollen shoulder and carpal joints; reluctance to stand; and pyrexia. Radiographs in both cases revealed an irregular lucent zone in the metaphysis of the proximal humerus, parallel and adjacent to the physis. The same lucent zone was also evident in the physes of the distal radial and ulnar metaphyses. Clinical signs and radiographs were consistent with hypertrophic osteodystrophy. Clinical signs resolved in both dogs with administration of carprofen, tramadol, and intravenous fluids. No signs of recurrence were reported at 3-month follow-ups.
Effects of Carprofen and Morphine on the Minimum Alveolar Concentration of Isoflurane in Dogs
Authors: Ko Jeff C.H. , Weil Ann B. , Inoue Tomohito
Published: September 2014

The minimum alveolar concentration (MAC) of isoflurane in dogs was determined following carprofen (2.2 mg/kg per os) alone, morphine (1 mg/kg intravenously) alone, carprofen and morphine, and no drug control in eight healthy adult dogs. Isoflurane MAC following administration of morphine alone (0.81%±0.18%) or carprofen and morphine (0.68%±0.31%) was significantly less than the control MAC (1.24%±0.15%). Isoflurane MAC after carprofen alone (1.13%±0.13%) was not significantly different from the control value. Results indicated that administration of morphine alone or in combination with carprofen significantly reduced the MAC of isoflurane in dogs. The isoflurane MAC reduction was additive between the effects of carprofen and morphine.
Embryonal Rhabdomyosarcoma in a Young Maine Coon Cat
Authors: Miller Andrew D. , Steffey Michele , Alcaraz Ana , Cooper Barry
Published: September 2014

Embryonal rhabdomyosarcomas are uncommon tumors in all domestic species, especially cats. A 14-month-old Maine coon was diagnosed with an embryonal rhabdomyosarcoma in the rectus abdominus muscle, which was treated with complete surgical excision. Although no clinical progression was noted after surgery, the cat succumbed to pulmonary metastasis within 7 months. The histological diagnosis was embryonal rhabdomyosarcoma (myotubular subtype). This category of striated muscle tumors is thought to have a more aggressive clinical course. The rapid demise of this cat even with no clinical or histological evidence of metastasis at the time of resection may indicate that, as in human medicine, adjuvant chemotherapy should be considered in conjunction with early surgical excision in preventing disease progression.
Surgical Removal of a Cuterebra Larva From the Cervical Trachea of a Cat
Authors: Bordelon Jude T. , Newcomb Brent T. , Rochat Mark C.
Published: September 2014

A case of cervical intratracheal cuterebriasis is reported. The cat was presented with intermittent dyspnea of 3 days’ duration. The larva was located during tracheoscopy but was not retrievable. Surgical exploration of the cervical region was performed, and the larva was removed. All clinical signs resolved upon recovery from surgery. The larva was identified as a second instar Cuterebra sp.
Evaluation of a Human On-site Urine Multidrug Test for Emergency Use With Dogs
Authors: Teitler Joan B.
Published: September 2014

A rapid, human on-site urine multidrug test was used to screen canine urine samples for the presence of five illegal drugs and drugs from three commonly abused drug classes. Each sample was sent to a toxicology laboratory for gas chromatography/mass spectrometry (GC/MS) validation. On-site test results and GC/MS assays confirmed that the human on-site test kit did identify barbiturates, opiates, benzodiazepines, and amphetamines/methamphetamines in urine from dogs that had received these common illicit drugs/drug classes either intravenously and/or orally. However, neither the on-site test kit nor the GC/MS individual assays for marijuana or methadone, a synthetic opiate, were effective in identifying marijuana and methadone in urine from dogs with suspected or known exposure. No index of suspicion was seen for exposure to phencyclidines or cocaine during the study period, and no exposures were indicated by the on-site test results. Overall, the test is a rapid, readily available, affordable, and useful complement to the veterinarian’s clinical consideration and professional judgment.
Intestinal Obstruction Caused by Taenia taeniaeformis Infection in a Cat
Authors: Wilcox Rebbecca S. , Bowman Dwight D. , Barr Stephen C. , Euclid James M.
Published: September 2014

An adult domestic shorthair (DSH) cat was presented with acute vomiting, anorexia, lethargy, and dyspnea. The cat’s clinical status worsened over 24 hours with conservative medical management. An exploratory celiotomy was performed. Acute intestinal obstruction resulting from infection with Taenia (T.) taeniaeformis was diagnosed. Surgical removal of the cestodes via multiple enterotomies resolved the obstruction. This paper reports, for the first time, small intestinal obstruction caused by T. taeniaeformis infection in a cat.
Ivermectin Toxicosis in Dogs: A Retrospective Study
Authors: Merola Valentin A , Khan Safdar , Gwaltney-Brant Sharon
Published: September 2014

Ivermectin is a commonly used veterinary drug that may cause serious problems in overdose situations. A retrospective study was completed, which evaluated canine exposures to ivermectin from 1998 to 2005. The cases were evaluated based on ivermectin dosage, clinical signs seen, signalment of the animal involved, and the potential that the animal could have a p-glycoprotein defect. Results showed that clinical signs may be seen in some animals at doses lower than previously reported. Some dogs may have p-glycoprotein defects or other reasons for increased susceptibility to ivermectin toxicosis. The clinician should be aware that clinical signs may develop even at dosages previously thought to be of little risk (e.g., 0.2 to 2.5 mg/kg in breeds historically considered to have normal p-glycoprotein function).
Clinical Relevance of Annual Screening Using a Commercial Enzyme-Linked Immunosorbent Assay (SNAP 3Dx) for Canine Ehrlichiosis
Authors: Hegarty Barbara C. , de Paiva Diniz Pedro Paulo Vissotto , Bradley Julie M. , Lorentzen Leif , Breitschwerdt Edward
Published: September 2014

Eighty-six dogs were selected based upon Ehrlichia (E.) canis SNAP 3Dx positive results to determine clinical relevance of annual E. canis screening. Immunofluorescence assay showed 72 (84%) of 86 dogs were seroreactive for E. canis. Polymerase chain reaction (PCR) revealed that 12 (14%) of 86 dogs had Ehrlichia deoxyribonucleic acid; seven had E. canis, four had E. ewingii, and one was coinfected with E. chaffeensis and E. ewingii. Thrombocytopenia (<164,000 platelets/μL) was found in 28 (39%) of 72 dogs. In this study, thrombocytopenia was frequently detected in healthy Ehrlichia SNAP 3Dx-positive dogs, whereas active infection was infrequently confirmed by PCR. Therefore, treatment based upon screening results alone is not recommended.
Reevaluation of Predictive Factors for Complete Recovery in Dogs With Nonambulatory Tetraparesis Secondary to Cervical Disk Herniation
Authors: Hillman Robert B. , Kengeri Seema S. , Waters David J.
Published: September 2014

The vast majority of dogs with cervical disk herniation experience cervical pain and only mild motor deficits; therefore, not much is known about the factors that predict recovery in dogs with nonambulatory tetraparesis (NAT) secondary to cervical disk herniation. In this retrospective study, we tested the hypothesis that two previously reported prognostic factors, site of disk herniation and severity of neurological deficits, are useful predictors of complete recovery. Overall, 20 (62%) of 32 dogs with cervical disk herniation-associated NAT had complete recovery. Site of disk herniation was not a significant predictor of complete recovery; dogs with high cervical lesions (C2 to C3, C3 to C4) did not have a higher likelihood of complete recovery than other dogs. Likewise, severity of neurological deficits (i.e., intact voluntary motor function versus absent voluntary motor function) was not a significant predictor of complete recovery. Using stepwise logistic regression, two significant predictors of complete recovery were identified. Small dogs (δ15 kg body weight) were six times more likely to achieve complete recovery than larger dogs. Dogs that regained the ability to walk within 96 hours after surgery were seven times more likely to completely recover than dogs not walking 96 hours after surgery. We conclude that neither the site of disk herniation nor severity of neurological deficits assists the clinician in predicting postoperative outcome in dogs with cervical disk herniation-associated NAT. Reliable preoperative predictors of complete recovery are needed to advance current diagnostic and treatment protocols to improve overall prognosis.
Combination Auriculopalpebral Nerve Block and Local Anesthesia for Placement of a Nictitating Membrane-to-Superotemporal Bulbar Conjunctiva Flap in Dogs
Authors: Park Shin Ae , Lee Inhyung , Lee Y. Lyon , Jeong Man Bok , Kim Won Tae , Kim Se Eun , Park Young Woo , Seo Kang Moon
Published: September 2014

The purpose of this study was to evaluate the efficacy of combined local anesthesia in dogs undergoing nictitating membrane (NM)-to-superotemporal bulbar conjunctiva flap construction. Medical records of 47 dogs that had received local anesthesia for NM-to-superotemporal bulbar conjunctiva flap were reviewed. Combined local anesthetic technique included auriculopalpebral nerve block, topical anesthesia of the eye, and infiltration anesthesia of the superotemporal bulbar conjunctiva and palpebral surface of the NM. Forty-two (89.3%) dogs complied with the anesthetic procedures and underwent NM flap without general anesthesia or sedation. No complications were related to the combined local anesthesia. Combined local anesthesia for NM-to-superotemporal bulbar conjunctiva flap may be a time- and cost-effective method that produces both analgesia of the surgical site and akinesia of the eyelid.
A Pilot Study Comparing the Diabetogenic Effects of Dexamethasone and Prednisolone in Cats
Authors: Lowe Andrew D. , Graves Thomas K. , Campbell Karen L. , Schaeffer David J.
Published: September 2014

Fourteen cats received either daily prednisolone (4.4 mg/kg per os [PO]) or dexamethasone (0.55 mg/kg PO) for 56 days. These doses were clinically equipotent. Serum fructosamine and urine glucose were measured on days 0, 28, and 56. Insulin sensitivity, glucose tolerance, and peak insulin secretion were measured in each group prior to and at the end of the courses of glucocorticoid administration. On day 56, the prevalence of glucosuria was significantly greater (P=0.027), and a trend was seen toward greater fructosamine concentrations (P=0.083) in dexamethasone-treated cats compared to prednisolone-treated cats. The results of this pilot study also showed a trend toward a greater decrease in insulin sensitivity (P=0.061) and a significantly lower compensatory increase in insulin secretion (P=0.081) in the dexamethasone-treated cats than in cats administered prednisolone. These preliminary data suggest that dexamethasone exhibits greater diabetogenic effects in cats than equipotent doses of prednisolone. Further study is justified to support this hypothesis.
Primary Bacterial Septic Peritonitis in Cats: 13 Cases
Authors: Ruthrauff Cassandra M. , Smith Julie , Glerum Leigh
Published: September 2014

The purpose of this paper is to describe the signalment, clinical signs, laboratory results, culture results, and response to treatment for primary septic peritonitis in cats. This is a retrospective study of 12 client-owned animals. Medical records were reviewed for clinical findings, laboratory results, microbial culture results, radiographic findings, diagnosis, treatment, and outcome. The overall mortality rate for this group of cats was 31%, consistent with previous reports of septic peritonitis in cats. All cats that were both bradycardic and hypothermic on presentation did not survive. Other clinicopathological findings were consistent with previously reported cases of septic peritonitis in cats. Results suggest that clinicopathological findings and outcomes in cats with primary septic peritonitis are similar to those in cats with septic peritonitis from a determined cause. A specific mechanism of inoculation has yet to be determined, but an oral source of bacteria is suggested for cats with primary bacterial septic peritonitis.
Multiple Distinct Malignancies in Dogs: 53 Cases
Authors: Rebhun Robert B. , Thamm Douglas H.
Published: September 2014

Despite the clinical recognition of multiple distinct types of neoplasia in individual dogs, a detailed description of such cases has not recently been published. Canine oncology cases that were diagnosed with multiple, confirmed, distinct malignancies were prospectively collected for analysis. Approximately 3% of 1722 dogs that were presented to the oncology service at the Colorado State University Veterinary Medical Center were diagnosed with multiple distinct primary tumors. No significant breed or sex predisposition was apparent. Dogs with mast cell tumor, malignant melanoma, and thyroid carcinoma were significantly overrepresented and thus more likely to be diagnosed with multiple tumor types. These findings emphasize the importance of thorough, whole-body evaluation for dogs presented with mast cell tumor, malignant melanoma, and thyroid carcinoma. Furthermore, because approximately 33% of dogs that were presented with thyroid tumors were found to have additional distinct tumors, complete staging is justified in all dogs presented with thyroid tumors.
Adrenal Pheochromocytoma With Contralateral Adrenocortical Adenoma in a Cat
Authors: Calsyn Jon David R. , Green Rebecca A. , Davis Garrett J. , Reilly Christopher M.
Published: September 2014

A 7-year-old, neutered male cat was presented with a 6-month history of progressive polyuria, polydipsia, polyphagia, aggression, and weight gain. Previous blood work, urinalysis, and radiographs did not delineate a cause for the clinical signs. An ultrasound revealed bilateral adrenal gland enlargement. A low-dose dexamethasone suppression test was consistent with hyperadrenocorticism. Based on these findings, bilateral adrenalectomy was attempted and successfully performed. Histopathology was consistent with a cortical adenoma in the right adrenal gland and a pheochromocytoma in the left adrenal gland. This association has never been reported in the cat.
The Use of Rim Excision as a Treatment for Canine Acanthomatous Ameloblastoma
Authors: Murray Rebecca L. , Aitken Martin L. , Gottfried Sharon D.
Published: September 2014

This study reviews rim excision as a treatment for canine acanthomatous ameloblastomas (CAA) in dogs with <3 mm of bone involvement. Removal of a canine tooth was involved in 47% of the cases; 33% cases involved the caudal dentition. Follow-up ranged from 3 months to 5 years. No evidence of recurrence was seen. Client satisfaction with cosmesis and the animal’s ability to masticate was judged to be good. With appropriate case selection, rim excision appears to be a viable option for CAA and results in improved dental occlusion, cosmesis, and no evidence of epulis recurrence.
A Retrospective Study of Factors Influencing Survival Following Surgery for Gastric Dilatation-Volvulus Syndrome in 306 Dogs
Authors: Mackenzie George , Barnhart Mathew , Kennedy Shawn , DeHoff William , Schertel Eric
Published: September 2014

Gastric dilatation-volvulus (GDV) is a life-threatening condition in dogs that has been associated with high mortality rates in previous studies. Factors were evaluated in this study for their influence on overall and postoperative mortality in 306 confirmed cases of GDV between 2000 and 2004. The overall mortality rate was 10%, and the postoperative mortality rate was 6.1%. The factor that was associated with a significant increase in overall mortality was the presence of preoperative cardiac arrhythmias. Factors that were associated with a significant increase in postoperative mortality were postoperative cardiac arrhythmias, splenectomy, or splenectomy with partial gastric resection. The factor that was associated with a significant decrease in the overall mortality rate was time from presentation to surgery. This study documents that certain factors continue to affect the overall and postoperative mortality rates associated with GDV, but these mortality rates have decreased compared to previously reported rates.
Primary Prostatic Leiomyosarcoma With Pulmonary Metastases in a Dog
Authors: Bacci Barbara , Vignoli Massimo , Rossi Federica , Gallorini Francesco , Terragni Rossella , Laddaga Ester L. , Sarli Giuseppe
Published: September 2014

A 6-year-old, intact male Jack Russell terrier was diagnosed with a mass in the caudal abdomen, and ultrasound revealed a large prostatic mass. A total-body computed tomography scan was performed for staging, and lung nodules were detected. Histological examination showed a proliferation of spindle cells arranged in interlacing fascicles. Immunohistochemical staining revealed cells were cytokeratin negative and immunoreactive for vimentin and α-smooth muscle actin; cells stained with desmin and S-100 were negative. A diagnosis of primary prostatic leiomyosarcoma with pulmonary metastases was made. This is one of the rare cases of primary prostatic mesenchymal tumor in the canine species.
Nasal Rhinosporidiosis in Two Dogs Native to the Upper Mississippi River Valley Region
Authors: Hill Sara A. , Sharkey Leslie C. , Hardy Robert M. , Wilke Vicki L. , Smith Meredith A. , Anderson Gregory M.
Published: September 2014

Two dogs, 4 and 7 years of age, were presented for evaluation and treatment of excessive sneezing. Physical examinations in both cases were within acceptable limits except for the presence of a single mass in the left nasal passage in the first case and left-sided nasal discharge in the second case. Rhinoscopy was used to visualize the nasal masses, and in both cases a single mass was surgically removed. Impression smears and histopathology submitted from each mass revealed lymphoplasmacytic and neutrophilic inflammation with spores typical of Rhinosporidium seeberi. These are the first reported cases of nasal rhinosporidiosis in two dogs native to the Upper Mississippi River Valley area with no travel history outside the region.
Spontaneous Feline Pneumothorax Caused by Ruptured Pulmonary Bullae Associated With Possible Bronchopulmonary Dysplasia
Authors: Milne Marjorie E. , McCowan Christina , Landon Ben P.
Published: September 2014

Spontaneous pneumothorax is rarely reported in the cat. This case report describes the use of computed tomography (CT) to diagnose pulmonary bullae in an adult cat with recurrent spontaneous pneumothorax. A large bulla in the right middle lung lobe and several blebs in other lobes were identified by CT. Partial lobectomy of the right middle and right and left cranial lung lobes was successfully performed to remove the affected portions of lung. Histopathological examination suggested bronchopulmonary dysplasia (BPD) as the underlying cause for development of the pulmonary bulla. This is the first case report in the veterinary literature describing the use of CT to identify pulmonary bullae in the cat with BPD as a possible underlying cause.
Primary Clitoral Adenocarcinoma With Secondary Hypercalcemia of Malignancy in a Dog
Authors: Neihaus Steven A. , Winter Jennifer E. , Goring Robert L. , Kennedy F. A. , Kiupel Matti
Published: September 2014

This report describes a primary clitoral adenocarcinoma in a dog with secondary hypercalcemia of malignancy. A 10-year-old, spayed female basset hound was evaluated for a mass protruding from the vulva. The mass was excised, and a histological diagnosis of clitoral adenocarcinoma was made. No evidence of metastasis on thoracic radiographs or abdominal ultrasound was seen. Preoperative hypercalcemia resolved following excision of the mass. Cellular features were similar to an apocrine gland anal sac adenocarcinoma, and immunohistochemistry exhibited features noted with apocrine gland anal sac adenocarcinoma. No further treatment was elected by the owner. Internal iliac lymph-node metastasis was identified 4 weeks postoperatively, and hypercalcemia recurred 8 weeks postoperatively. The dog was euthanized 22 weeks postoperatively for signs related to hypercalcemia, including polyuria/polydipsia, lethargy, and weakness. A necropsy was performed and confirmed the presence of internal iliac lymph-node metastasis. The colon, rectum, and anal sacs were grossly and histologically normal. To our knowledge, this is the first reported case of clitoral neoplasia in the dog.
Heterobilharzia americana Infection and Glomerulonephritis in a Dog
Authors: Ruth Jeffrey
Published: September 2014

Schistosomiasis is an uncommonly reported disease that usually causes weight loss, anemia, and gastrointestinal signs. A 6-year-old, neutered male dog developed membranoproliferative glomerulonephritis concurrent with infection with the trematode parasite Heterobilharzia americana. At presentation, the dog had proteinuria, hypoalbuminemia, hyperglobulinemia, and anemia. Diagnosis was based upon the histopathological appearance of the kidney. Clinical signs, biochemical and hematological abnormalities, and proteinuria resolved following treatment with fenbendazole and praziquantel. Fecal examination by saline sedimentation, miracidia hatching, or Heterobilharzia polymerase chain reaction assay may be indicated when examining a dog that is presented with unexplained glomerulonephritis and is from an endemic area.
Association Between Serum Triglyceride and Canine Pancreatic Lipase Immunoreactivity Concentrations in Miniature Schnauzers
Authors: Xenoulis Panagiotis G. , Suchodolski Jan S. , Ruaux Craig G. , Steiner Jörg M.
Published: September 2014

The objective of this study was to investigate possible associations between serum triglyceride and canine pancreatic lipase immunoreactivity (cPLI) concentrations in miniature schnauzers. One hundred and ninety-five miniature schnauzers were enrolled and divided into two groups based on whether they had normal (group 1) or increased (group 2) serum triglyceride concentrations. Serum cPLI concentrations were measured and compared between groups. A significant positive correlation was seen between serum triglyceride and cPLI concentrations (Spearman r=0.321; P<0.0001). Miniature schnauzers with hypertriglyceridemia had a significantly higher median serum cPLI concentration (99.5 μg/L) than miniature schnauzers with normal serum triglyceride concentrations (median cPLI concentration 39.3 μg/L; P=0.0001). A cutoff value of 862 mg/dL was selected for serum triglyceride concentrations based on receiver operator characteristic analysis. Miniature schnauzers with severe hypertriglyceridemia (≥862 mg/dL) were 4.5 times more likely to have a serum cPLI concentration consistent with pancreatitis (≥200 μg/L) than miniature schnauzers with a normal serum triglyceride concentration. The present study supports an association between hypertriglyceridemia (especially when severe [≥862 mg/dL]) and high cPLI concentrations in miniature schnauzers.
Diagnosis of Congenital Portosystemic Shunt in Miniature Schnauzers 7 Years of Age or Older (1997–2006)
Authors: Mertens Michelle , Fossum Theresa W. , Willard Michael D. , Fosgate Geoffrey T. , de la Paz Angel Garcia , Farmer Ryan , Miller Matthew W.
Published: September 2014

Dogs with congenital portosystemic shunt (PSS) are typically diagnosed before 2 years of age. The objective of this study was to determine if miniature schnauzers are more likely to be diagnosed with congenital PSS at an older age than are other breeds. This retrospective study examined the case records of 171 dogs diagnosed with congenital PSS; dogs were included if they were definitively diagnosed as having congenital PSS by nuclear scintigraphy, contrast portography, and/or exploratory surgery. Seven (23%) of 31 miniature schnauzers diagnosed with congenital PSS were 7 years of age or older at the time of diagnosis, compared to 3.4% for all other breeds. Miniature schnauzers had a relative prevalence ratio of 6.3 (95% confidence interval 2.2 to 18.6; P=0.001) for being diagnosed at or after 7 years of age when compared to all other breeds of dogs. Clinical signs of congenital PSS may not manifest sufficiently to cause an owner to seek veterinary care for some dogs until they are older. Congenital PSS should be considered in mature dogs, particularly miniature schnauzers, that are presented with signs potentially consistent with hepatic encephalopathy.
Clinical and Neuropathological Findings of Acute Carbon Monoxide Toxicity in Chihuahuas Following Smoke Inhalation
Authors: Kent Marc , Creevy Kate E. , deLahunta Alexander
Published: September 2014

Three adult Chihuahuas were presented for evaluation after smoke inhalation during a house fire. All three dogs received supportive care and supplemental oxygen. After initial improvement, the dogs developed seizures. Despite anticonvulsant therapy and supportive care, the dogs died. The brains of two dogs were examined. Lesions were identified that were compatible with acute carbon monoxide (CO) toxicity. Lesions were confined to the caudate nucleus, the globus pallidus, and the substantia nigra bilaterally, as well as the cerebellum, cerebral cortex, and dorsal thalamus. This case report describes the clinicopathological sequelae in acute CO toxicity.