bluuebunny/crossref_metadata_2025 huggingface dataset:
عَلاَمَات ومَرَاحِل سَرَطان الثَّدْي‎ عند التَّشْخيص خِلاَل النِّزَاع النَّشِط في شمال غرب سورية
Authors: المطير يحيى , الداود فؤاد , مشتاق جوهر , حريري محمود
Published: October 2024

الهَدْف: دراسة العَلاَمَات السريرية للمرضى المصابين بسرطان الثَّدْي‎ في شمال غرب سورية، وتحديد نوع سرطان الثَّدْي‎ والمرحلة السريرية عند التَّشْخيص.  المنهجية: شملت الدراسة 39 مريضًا من المرضى المراجعين لعيادة الجراحة العامة في مشفى إدلب الجامعي في الفترة الواقعة بين عام 2021-2023 . تم جمع البيانات عبر استمارة خاصة، وخضع جميع المرضى للتقييم الثلاثي للثدي (القصة المرضية والفحص السريري، والاستقصاءات الشعاعية، والخزعة)،  ومن ثم تم إجراء العمل الجراحي المناسب، والدراسة النَّسِيْجيَّة للعينة المستأصلة بعد العمل الجراحي. النتائج: أظهرت النتائج أنَّ متوسط أعمار المرضى المصابين بسرطان الثَّدْي‎ بلغ (48.6±13.77) حيث تراوحت أعمارهم مابين 24 سنة و83 سنة، وقد  أظهر الفحص الفيزيائي أنَّ جميع المرضى كانت لديهم كتلة ثدي مجسوسة  حيث بلغ متوسط حجم الوَرَم (29 ±13.38 mm). من الناحية النَّسِيْجيَّة لوحظ أنَّ 98% من حالات سرطان الثَّدْي‎ التي تم تشخيصها كان سَرَطانَات غَزْويَّة و2% سَرَطانَة غير غَزْوِيَّة (لَاَبِدَة‎)، ومن حيث نوع السَرَطانَة كانت 76.9% من سَرَطانَة سَرَطانَة‎ قَنَوِيَّة غَزْوِيَّة (IDC)، في حين بلغت نسبة السَرَطانَة الفُصَيصِيَّة الغَزْوِيَّة (ILC)12.8% ، ونسبة السَرَطانَة المُخاطِيَّة (MC) 2.6%، ونسبة السَرَطانَة القنوية الفُصَيصِيَّة (IDC+ILC) 2.6% كانت درجة الوَرَم لدى 61.5% من المرضى من الدرجة II. بينت نتائج المَرَضِيَّات النَّسِيْجيَّة لسرطان الثَّدْي‎ أنَّ 51.3% من المرضى في المرحلة الباكرة و48.7%من المرضى في المراحل المتأخرة من المرض. الخلاصة: إِنَّ سرطان الثَّدْي‎ في شمال غرب سورية يصيب الذكور والاناث، توزعت الإصابات بنسبة 94.9% عند النساء(37 حالة)، و 5.1% عند الذكور (حالتين) ومعظم المرضى المراجعين كانوا في مراحل متقدمة من الإصابة، ويعانون من أعراض وعَلاَمَات متأخرة لسرطان الثَّدْي‎. لذلك فإن الحاجة ملحة لتطوير مهارات فحص الثَّدْي‎ الذاتي ووضع برامج مسح استقصائي للكشف المبكر عنه واعتمادها من قبل السلطات الصحية المحلية.
Metaproteomics beyond databases: addressing the challenges and potentials of de novo sequencing
Authors: Van Den Bossche Tim , Beslic Denis , van Puyenbroeck Sam , Suomi Tomi , Holstein Tanja , Martens Lennart , Elo Laura L. , Muth Thilo
Published: October 2024

Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within their environments. By directly analyzing proteins, metaproteomics offers insights on community phenotypes and the roles individual members play in diverse ecosystems. While database-dependent search engines are commonly used for peptide identification, they rely on pre-existing protein databases, which can be limiting for complex, poorly characterized microbiomes. De novo sequencing presents a promising alternative, which derives peptide sequences directly from mass spectra without requiring a database. Over time, this approach has evolved from manual annotation to advanced graph-based, tag-based, and deep-learning-based methods, significantly improving the accuracy of peptide identification. This Viewpoint explores the evolution, advantages, limitations, and future opportunities of de novo sequencing in metaproteomics. We highlight recent technological advancements that have improved its potential for detecting unsequenced species and for providing deeper functional insights into microbial communities.
From the Relativistic Interpretation of Planck’s Equation to Theoretical Estimation of Photon’s Intrinsic Properties: The Revised Relativistic Doppler Effect
Authors: Alibakhshi Amin
Published: October 2024

This study identifies a previously overlooked peculiarity resulted by the relativistic Doppler effect, suggesting a possible violation of photon energy conservation by a thought experiment. To resolve this, a revised theory is proposed relying on considering fixed intrinsic properties for photons in their rest frame, called the Light Intrinsic Frame of Reference (LIFOR). This theory preserves the constancy of light speed, is fully consistent with special relativity, and explains frequency shifts through Lorentz transformations, leading to a relativistic justification for Planck’s quantization of radiation energy.
Exploring CRISPR-Cas9 HNH-Domain Catalyzed DNA Cleavage Using Accelerated Quantum Mechanical Molecular Mechanical Free Energy Simulation
Authors: Van Richard , Pan Xiaoliang , Rostami Saadi , Liu Jin , Agarwal Pratul , Brooks Bernard , Rajan Rakhi , Shao Yihan
Published: October 2024

The target DNA (tDNA) cleavage catalyzed by the CRISPR Cas9 enzyme is a critical step in the Cas9-based genome editing technologies. Previously, the tDNA cleavage from an active SpyCas9 enzyme conformation was modeled by Palermo and coworkers [Nierzwicki et al., Nat. Catal. 5, 912 (2022)] using ab initio quantum mechanical molecular mechanical (ai-QM/MM) free energy simulations, where the free energy barrier was found to be more favorable than that from a pseudoactive enzyme conformation. In this work, we performed ai-QM/MM simulations based on another catalytically active conformation (PDB 7Z4J) of the Cas9 HNH domain from cryo-electron microscopy experiments.For the wildtype enzyme, we acquired a free energy profile for the tDNA cleavage that is largely consistent with the previous report. Furthermore, we explored the role of the active-site K866 residue on the catalytic efficiency by modeling the K866A mutant, and found that the K866A mutation increased the reaction free energy barrier, which is consistent with the experimentally observed reduction in the enzyme activity.
Magnetically Responsive Enzyme and Hydrogen-bonded Organic Framework Biocomposites for Biosensing
Authors: Carraro Francesco , Aghito Margherita , Dal Zilio Simone , Wolinski Heimo , Doonan Christian , Nidetzky Bernd , Falcaro Paolo
Published: October 2024

We report the one-pot synthesis of multicomponent hydrogen-bonded organic framework (HOF) biocomposites. The coimmoblization of magnetic nanoparticles (MNPs) and enzymes into the HOF crystals yielded a nano-composite biocatalytic material (MNPs-enzyme@BioHOF-1) that posses dynamic localization properties. Using a permanent magnet, it is possible to separate the MNPs-enzyme@BioHOF-1 particles from a solution. When coimmobilized with MNPs, Catalase (CAT) and glucose oxidase (GOx) showed an increased retention of their activity when coimmobilized with MNPs. MNPs-GOx@BioHOF-1 biocomposites were used to prepare a proof-of-concept glucose microfluidic biosensor, where a magnet allowed to position and keep in place the biocomposite inside a microfluidic chip. The magnetic response of these biocatalysts can pave the way to new applications for the emerging HOF biocomposites
Turning on Organic Radical Emitters
Authors: Dubbini Matteo , Bonvini Federico , Savi Lorenzo , Di Maiolo Francesco
Published: October 2024

Radical emitters have attracted considerable interest because of their potential to surpass the limitations of singlet emitters due to spin statistics, thereby revolutionizing organic LEDs. Utilizing the well-known Pariser-Parr-Pople (PPP) model for correlated electrons in π-conjugated systems, we perform extended CISDT (XCISDT) calculations to explore the photophysics of various phenalenyl radicals differently decorated with nitrogen atoms. By introducing the PPP particle-hole difference operator and connecting it to DFT calculations, we offer a new tool for predicting highly emissive organic radicals using ground state quantum chemistry methods.
MALDI-2 Mass Spectrometry Imaging enables spatial visualization of endocannabinoids in brain
Authors: Salviati Emanuela , Guida Francesca , La Gioia Danila , Merciai Fabrizio , Maione Sabatino , Di Marzo Vincenzo , Campiglia Pietro , Piscitelli Fabiana , Sommella Eduardo
Published: October 2024

Endocannabinoids (eCBs) are endogenous lipid messengers that primarily bind cannabinoid receptors CB1/CB2 and together with the enzymes that regulate their biosynthesis and degradation define the endocannabinoid system. The eCB signaling system plays a key role in the central nervous system, resulting altered in most neurological disorders. The analysis of eCBs is challenging for their low concentration in biospecimens, and this is exacerbated in Mass Spectrometry Imaging (MSI) where low sensitivity and tissue dependent ion suppression obscure their spatial visualization. In this work we address this limitation by the application of laser-induced post-ionization (MALDI-2). Herein we demonstrate that MALDI-2 boosts the detection of 2-arachidonylglycerol (2-AG) and N-acylethanolamines (AEA, PEA, OEA) with respect to MALDI, and that eCBs can be visualized in brain at endogenous concentration only by MALDI-2-MSI. Both root-mean-square (RMS) and deuterated internal standards (I.S.) normalization were evaluated, with I.S. normalization providing improved pixel to pixel variation and more uniform distribution in specific brain regions, especially for 2-AG and PEA. Furthermore, high lateral resolution up to 5 µm pixel size was evaluated, resulting in the detection of all eCBs and confirming the MALDI-2 potential even reducing the ablated tissue amount. Lastly the method was applied as proof of concept in a mouse model of mild traumatic brain injury demonstrating the ability to reveal valuable biological insights for neuropharmacology.
Mitochondria remodeling during endometrial stromal cell decidualization
Authors: Dalla Torre Marco , Pittari Daniele , Boletta Alessandra , Cassina Laura , Sitia Roberto , Anelli Tiziana
Published: October 2024

Upon hormonal stimulation, uterine endometrial stromal cells undergo a dramatic morpho-functional metamorphosis that allows them to secrete large amounts of matrix proteins, cytokines, and growth factors. This step, known as decidualization, is crucial for embryo implantation. We previously demonstrated how the secretory pathway is remodelled during this process. Here we show that hormonal stimulation rapidly induces the expression of many mitochondrial genes, encoded in both the mitochondrial and the nuclear genomes. Altogether, the mitochondrial network quadruples its size and establishes more contacts with the ER. This new organization results in the increased respiratory capacity of decidualized cells. These findings reveal how achieving an efficient secretory phenotype requires a radical metabolic rewiring.
Cholesterol promotesIFNGmRNA expression in CD4+effector/memory cells by SGK1 activation
Authors: Hanin Aurélie , Comi Michela , Sumida Tomokazu S , Hafler David A
Published: October 2024

IFNγ-secreting T cells are central for the maintenance of immune surveillance within the central nervous system (CNS). It was previously reported in healthy donors that the T-cell environment in the CNS induces distinct signatures related to cytotoxic capacity, CNS trafficking, tissue adaptation, and lipid homeostasis. These findings suggested that the CNS milieu consisting predominantly of lipids mediated the metabolic conditions leading to IFNγ-secreting brain CD4 T cells. Here, we demonstrate that the supplementation of CD4+CD45RO+CXCR3+cells with cholesterol modulates their function and increasesIFNGexpression. The heightenedIFNGexpression was mediated by the activation of the serum/glucocorticoid-regulated kinase (SGK1). Inhibition of SGK1 by a specific enzymatic inhibitor significantly reduces the expression ofIFNG. Our results confirm the crucial role of lipids in maintaining T-cell homeostasis and demonstrate a putative role of environmental factors to induce effector responses in CD4+effector/memory cells. These findings offer potential avenues for further research targeting lipid pathways to modulate inflammatory conditions.
Hubungan Kadar Vitamin D3 Dengan Derajat Kepositifan BTA Pada Penderita Tuberkulosis Paru
Authors: Kuncara Rachmad Bayu , Istiqomah Anisa , Hartono Rodhi , Priyatno Djoko
Published: October 2024

Tuberkulosis paru adalah penyakit menular yang disebabkan bakteri Mycobacterium tuberculosis (MTB). Pemeriksaan mikroskopis Bakteri Tahan Asam (BTA) merupakan pemeriksaan yang penting untuk membantu diagnosis tuberculosis paru. Penderita tuberculosis paru dapat mengalami peningkatan jumlah BTA apabila mengalami defisiensi vitamin D. Vitamin D dapat menghambat multiplikasi MTB dalam makrofag dengan induksi peptida anti mikroba. Penelitian ini bertujuan untuk mengetahui hubungan kadar vitamin D3 dengan derajat kepositifan bakteri tahan asam pada penderita tuberkulosis paru. Jenis penelitian ini adalah observasional analitik dengan desain cross sectional. Sampel penelitian sebanyak 30 responden diambil dari Puskesmas Bangetayu, Puskesmas Tlogosari Wetan, dan Puskesmas Kedungmundu di Kota Semarang. Sampel tersebut diperiksa BTA secara mikroskopis dan pemeriksaan vitamin D3 dilakukan dengan metode Enzym Linked Immunosorbent Assay (ELISA). Hasil pemeriksaan BTA menunjukan sebanyak 12 (40,0%) penderita dengan hasil scanty, sebanyak 7 (23,3%) penderita positif 1, sebanyak 7 (23,3%) penderita positif 2 dan 4 (13,4%) penderita positif 3. Hasil pemeriksaan vitamin D menunjukan sebanyak 23 (76,7%) penderita dengan status defisiensi, 5 (76,7%) penderita dengan status insufisiensi dan 2 (6,7%) penderita dengan status sufisiensi. Data tersebut dianalisa secara statiskik menggunakan uji Spearman dengan hasil p-Value = 0,023 (p< 0,05) sehingga dapat disimpulkan terdapat hubungan kadar vitamin D3 dengan derajat kepositifan BTA pada penderita tuberculosis paru.
DEVELOPMENT OF AN ANDROID-BASED APPLICATION "BERAKSI" TO CONDUCT EARLY DETECTION OF STUNTING
Authors: Susanti Dyeri , Juaeriah Ryka , Fatonah Sofa , Wahyuni Sri
Published: October 2024

Stunting is a condition of failure to thrive in children under five years of age (toddlers) due to chronic malnutrition and recurrent infections, especially during the window of opportunity, namely from the fetus to a child aged 23 months. Children are classified as stunted if their length or height is below minus two standard deviations of the size or height of children their age. Stunting handling must synergize between ministries/institutions, regional governments, and the business world/community. The BERAKSI application is expected to help and make it easier for Cadres and parents to monitor the growth and development of typical toddlers in general and stunted toddlers in particular. Cadres can conduct inspections on Integrated Service Post activities, and parents can monitor the development of babies and toddlers at any time through the application on their respective smartphones. The BERAKSI application displays four menu features, namely the inspection feature: 1) Growth, 2) Development, 3) Balanced Nutrition, and 3) Parenting. The advantage of the BERAKSI Program application compared to similar applications is that it has updates in the form of interventions providing balanced nutrition for toddlers who experience stunting and malnutrition with menus that have been consulted and recommended by nutritionists, as well as having a parenting menu that has been consulted and recommended by child psychologists. Field data input into the BERAKSI application can be saved and downloaded on Google Spreadsheet. The BERAKSI application can be downloaded without paying via Playstore using an Android-based mobile device connected to the internet network.
Innovative approaches in chronic pain management
Authors: Geetha Kumari Das , Rehan Haider , Asghar Mehdi , Zameer Ahmed , Sambreen Zameer
Published: October 2024

Chronic pain is a complex condition that significantly impacts patients' quality of life and presents a substantial burden on healthcare systems. This paper reviews innovative approaches to chronic pain management, addressing existing pharmacological options and integrating therapies. In the context of emerging pharmacological treatments, including biologics and novel analgesics, targeted pain pathways are evaluated for their potential to provide more effective and reliable pain relief. Additionally, advancements in neuromodulation techniques, such as sleep-inducer rope provocation and Transcutaneous Electrical Nerve Stimulation (TENS), are explored for their role in modulating pain signals and reducing reliance on opioids. The integration of behavioral health sciences through mobile technology and wearable devices is examined for their ability to enhance patient self-management and facilitate real-time pain monitoring. Furthermore, this paper discusses the importance of combining various branches of care models that integrate medical, psychological, and physical therapy approaches to address the multifactorial nature of chronic pain. Case studies and objective challenges are reviewed to highlight the effectiveness and obstacles of these innovative approaches. By adopting a holistic and patient-centered perspective, this paper aims to provide a comprehensive understanding of future directions in chronic pain management, emphasizing the need for ongoing research and collaboration with healthcare professionals to improve patient outcomes and quality of life.
Kamu İç Denetçilerinin Mesleki Bağımsızlık Algılarının Mesleki Bağlılık Algısı Üzerindeki Etkisinin İncelenmesi: Üniversiteler Örneği (cInvestigation of the Effect of Public Internal Auditors Perceptions of Professional Independence on the Perception of Professional Commitment: A Case of Universities)
Authors: Yeşiltaş Arzu , Kurt Ganite
Published: October 2024

Bu araştırmada Türkiye’de devlet üniversitelerinde görev yapan iç denetçilerin mesleki bağlılıklarını etkileyen faktörlerin ortaya konulması amaçlanmaktadır. Oluşturulan modelin değişkenlerine dayalı olarak hazırlanan anket formu Google Forms aracılığıyla Türkiye’deki devlet üniversitelerinde görevalaniç denetçilere uygulanmış ve 118 adet veri toplanmıştır. Araştırmada yer alan değişkenler arasındakiilişkileri belirlemek amacıylaYapısal Eşitlik Modellemesi (YEM) analizi, iç denetçilerin değişkenlere yönelik algılarının demografik özelliklerine göre farklılaşıp farklılaşmadığını belirlemek amacıyla ise tek yönlü ANOVA testi gerçekleştirilmiştir. Yapılan YEM analizi sonucunda meslek etik algısının mesleki bağımsızlık algısı üzerinde; mesleki bağımsızlığının ise mesleki bağlılık üzerinde istatistiki olarak anlamlı ve pozitif yönde etkilerinin olduğu ortaya konmuştur. Ttesti sonuçlarına göreiç denetçilerin mesleki etik algılarının, meslek bağımsızlık algılarının ve mesleki bağlılıklarının cinsiyetlerine göre istatistiki olarak farklılaşmadığı; mesleki etik algıları ve mesleki bağımsızlık algılarının medeni duruma göre istatistiki olarak anlamlı bir şekilde farklılaştığı, buna karşın mesleki bağlılıklarının istatistiki olarak farklılaşmadığı sonucuna ulaşılmıştır. Aynı zamanda gerçekleştirilen tek yönlü ANOVA testi sonucunda ise iç denetçilerin meslek etiği algılarının, mesleki bağımsızlık algılarının ve mesleki bağlılıklarının yaşlarına, öğrenim düzeylerine ve deneyim sürelerine göre istatistiki olarak farklılaşmadığı tespit edilmiştir.
KNOWING THE PARTS OF SPEECH – AN INTERDISCIPLINARY INNOVATIVE LESSON FOR THIRD GRADE
Authors:   First Primary School ‘St. Cyril and St. Methodius’, Gotse Delchev, Kachanova Venelina , Petrova Teodora ,   First Primary School ‘St. Cyril and St. Methodius’, Gotse Delchev
Published: October 2024

„Knowing the Parts of Speech“ is an interdisciplinary lesson that integrates knowledge from Bulgarian language, social studies, science, music, and information technology. The aim of this lesson is to consolidate students’ understanding of the parts of speech, enhance their ability to identify grammatical categories, and improve proper pronunciation and spelling. Additionally, it commemorates World Water Day, highlighting its significance for all living organisms. The lesson begins with a multimedia presentation and a brief discussion. It transitions smoothly by revisiting prior knowledge about the parts of speech, after which the third graders identify the word “water“ as a noun and discuss its grammatical features, including related words. Students are divided into teams to solve worksheets. They trace the paths of studied rivers on the map of Bulgaria and identify and correct spelling errors in a text reviewing the properties of water. To reinforce their knowledge, students play educational games on the Nearpod platform. The lesson concludes with a song, “Gratitude to Water.“ This lesson reinforces knowledge of the parts of speech, improves pronunciation and spelling skills, and commemorates World Water Day, emphasizing the importance of water for all living organisms.
Novel Investigations of m-Bi-Ideals and Generators in b-Semirings with Extended Operator Frameworks
Authors: Suguna M. , Saranya K. , Salahuddin
Published: October 2024

In this study, we introduce novel types of m-quasi-ideals and m-bi-ideals in the context of b-semirings, expanding the scope of algebraic structures in this field. We provide detailed characterizations of these ideals, focusing on their distinct properties and interactions within b-semirings. Utilizing an algebraic approach, we elucidate the fundamental properties of m-bi-ideals, examining their behavior and structural role. Additionally, we explore the generators of m-bi-ideals and offer characterizations based on their relationship with bi-ideals. Our findings contribute to a deeper understanding of m-ideals and m-bi-ideals, opening new avenues for further research in algebraic theory and the study of semirings.
Development of a Construct 2-Based Platformer Game: Challenges and Implementation for Players of All Ages
Authors: Elistatia Usi , Permatasari Sisca , Permatasari Intan
Published: October 2024

This study aims to develop a Construct 2-based platformer game designed to provide an interactive and challenging gameplay experience for players of all ages. The game features key elements such as character movement, object collection missions, and enemy obstacles that players must avoid. The development process involved multiple stages, including requirements analysis, prototype creation, and alpha and beta testing. A scoring and life system was also implemented to enhance gameplay appeal and increase the challenge. Testing and feedback from external players helped refine control elements and level design. The final results demonstrate that this platformer game delivers an enjoyable experience while enhancing players' critical thinking and problem-solving skills. Construct 2 proved to be an effective platform for developing simple yet high-quality games.
Implement the Analytical Hierarchy Process (AHP) and K-Nearest Neighbor (KNN) Algorithms for Sales Classification
Authors: Husna Asmaul , Retno Sujacka , Rijal Himmatur
Published: October 2024

The Analytical Hierarchy Process (AHP) and K-Nearest Neighbor (KNN) algorithms are two algorithms that have proven efficient in various classification and prediction applications. This research examines the application of these two algorithms in the context of selling goods in PIM supermarkets. In this research, AHP and KNN are used to classify goods sold based on various criteria such as price, number of stock items sold, total sales amount. The research results show that KNN outperforms AHP in predicting the best-selling, best-selling and least-selling items based on sales in 2022 at PIM supermarkets. Based on this research, it can be concluded that the KNN algorithm is suitable for predicting the classification of goods sales in PIM Supermarkets. This research classifies sales of goods using the Analytical Hierarchy Process (AHP) and K-Nearest Neighbor (KNN) methods. This research uses 3 criteria. By using the value K=1, the experimental results show that the highest KNN has an accuracy of 38%, while AHP has an accuracy of 32%. Differences in accuracy results can be influenced by parameter settings and characteristics of the dataset used. Therefore, further analysis of these factors is needed to understand the performance differences between the two methods.
INFORMATION LITERACY INSTRUCTION METHODS FOR DIVERSE LEARNERS
Authors: Jagmohan Meena
Published: October 2024

Information literacy instruction is a critical component of modern education, empowering learners with the skills to locate, evaluate, and use information effectively. In the increasingly diverse educational landscape, it has become essential to tailor instructional methods to meet the varying needs of learners from different backgrounds, abilities, and learning styles. This study explores the various information literacy instruction methods designed for diverse learners, examining their effectiveness, strengths, weaknesses, and current trends. The research highlights the growing demand for inclusive educational approaches that cater to linguistic, cultural, and neurodiverse groups. This paper also addresses the necessity of adapting library instruction methods to meet the needs of 21st-century learners in a rapidly evolving information environment.
USER-CENTRIC DIGITAL SOLUTION FOR DIABETIC PATIENTS
Authors: Bachate Ravindra , Purohit Manali
Published: October 2024

Diabetes is a common chronic disorder that affects millions of people globally, necessitating careful management and support. This research paper explores the multifaceted aspects of the user experience (UX) of diabetes patients, understanding their unique needs, challenges, and the potential for improving their quality of life through innovative design solutions. Our research methodology included in-depth interviews, surveys, and user observations, engaging a different types diabetes patients. The insights underscore the significance of personalized, empathetic, and user-centric design in enhancing the UX of diabetes patients. The paper concludes by discussing key recommendations for future design, emphasizing the need for a holistic approach that encompasses both the physical and emotional aspects of diabetes care.
ANALISA DERAJAT KEJENUHAN DAN BIAYA OPERASIONAL KENDARAAN (Studi Kasus Jalan Kyai Muntang Wonosobo)
Authors: Muyassaroh Bariatul , Ummul A Nur Rizka , Maulani S Azza
Published: October 2024

Hambatan samping dapat menyebabkan penurunan kecepatan lalu lintas, yang selanjutnya menimbulkan terjadinya kemacetan lalu lintas. Hambatan samping yang dimaksud adalah pejalan kaki/pedestrian, kendaraan parkir/berhenti, kendaraan keluar/masuk dan kendaraan lambat. Faktor hambatan samping yang paling besar menyebabkan kemacetan adalah yang faktor disebabkan oleh parkir kendaraan dan kendaraan keluar masuk. Penurunan kecepatan kendaraan akibat kemacetan berdampak pada peningkatan waktu dari waktu tempuh yang seharusnya. Ketika terjadi kemacetan pada suatu lajur, maka terjadi kerugian waktu tempuh yang dialami oleh para pengendara. Meningkatnya BOK (biaya operasional kendaraan) perkotaan akan berakibat pada peningkatan biaya kemacetan yang berkaitan dengan nilai kegiatan masyarakat perkotaan. Tujuan dari penelitian ini adalah untuk menganalisa akibat pengaruh hambatan samping terhadap kinerja jalan pada ruas jalan dan perbandingan biaya operasional kendaraan tersebut berdasarkan Manual Kapasitas Jalan Indonesia (MKJI). Berdasarkan hasil analisis perhitungan nilai derajat kejenuhan 1,22 dimana angka tersebut sudah termasuk jenuh, sehingga kecepatan yang dihasilkan kendaraan tergolong lambat. Derajat kejenuhan 1,22 memiliki indeks tingkat pelayanan F : kondisi arus lalu lintas yang terhambat, kecepatan rendah, volume di bawah kapsitas, banyak berhenti. Besarnya kerugian BOK akibat aktivitas dibadan jalan mencapai 3%.
Anais do I Congresso Nacional de Metodologias Ativas e Tecnologias Educacionais
Authors: Sousa Maiara Gadelha de , Silva Cliciano Vieira da , Souza Felipe Rodrigues de , Santos Silvana Maria Aparecida Viana , Franqueira Alberto da Silva
Published: October 2024

Livro
DETERMINAÇÃO DA TENACIDADE À FRATURA DE UM AÇO TIPO AISI 4140 EM MODO III DE ABERTURA COM EMPREGO DE NOVA METODOLOGIA PROPOSTA.
Authors: Nascimento Murilo Viveiros do , Simão Larissa Gomes , Carvalho Eduardo Atem de
Published: October 2024

Na Indústria, os aços de médio carbono e alta resistência mecânica são também usados de forma frequente na fabricação de eixos, molas e outras partes submetidas a esforços de torção. Um exemplo é o aç
Perfil de competencias de los docentes de la carrera de Enfermería en una Universidad pública de Paraguay
Authors: Almeida Panza Miguel Porfirio , Del Padre Bentrón Lira Andrea , Vazquez Alcaraz Juan José
Published: October 2024

Una competencia es un conjunto integrado de conocimientos, capacidades, representaciones y comportamientos movilizados para resolver problemas profesionales. Ser competente implica poder realizar una actividad profesional, resolver problemas o desarrollar proyectos en tiempo oportuno movilizando integralmente un saber realizar, conjuntamente con los saberes conceptuales pertinentes y con capacidades diversas de acción y de relación, con el fin de obtener resultados de calidad. El objetivo de la investigación fue describir el perfil de competencias de los docentes de la Carrera de Enfermería de una universidad pública de Paraguay, en el año 2022. La investigación fue de tipo cuantitativo, de nivel descriptivo y diseño no experimental. Se trabajó con una población constituida por 42 docentes, mediante un muestreo censal. El instrumento de recolección de datos que se utilizó fue la encuesta por medio del cuestionario y la observación documental, elaborado en base a cada objetivo específico. Como resultados destacaron: 69% de los docentes fueron del sexo femenino, 52% con más de 10 años en la docencia, y 57% con formación especialista. En cuanto a las competencias específicas, en todos los indicadores los participantes se puntuaron en nivel excelente sobre el 80%, lo que también fue evidenciado en las competencias trasversales. En conclusión, los docentes poseen competencias específicas y genéricas o transversales para el cumplimiento del desarrollo de la enseñanza en la educación superior en niveles elevados, según la capacidad, habilidad, práctica, valores y actitudes para realizar el proceso de enseñanza.
The impact of climate change on the ecology, reproduction and distribution of marine mammals and the possible legislation, conservation and management approaches to protect these marine mammal species: A systematic review
Authors: Lakhnarayan Kumar Bhagarathi  , Phillip N. B. DaSilva  , Gyanpriya Maharaj  , Rahaman Balkarran  , Aarif Baksh  , Sushmita Kalika-Singh  , Ferial Pestano  , Chalasa Cossiah
Published: October 2024

This paper aims to review and evaluate published literature on the impact of climate change on marine mammals. A systematic method was utilized to access research works of literature on “Impact of Climate Change on Marine Mammals”. A total of eighty-two (82) research papers published between the years 1976 to 2024 were accumulated and used for this review. A subjective approach was used to select the topics: impact of climate change and marine mammals. In this paper, nine (9) direct and indirect effects of climate change and environmental factors affecting marine mammals were assessed in this paper. Further, six (6) detrimental impacts of climate change on marine mammals were evaluated and presented. In addition, an integrated checklist of one hundred twenty-seven (127) marine mammal species were presented along with their current IUCN Red List status categories. Subsequently, a total of eighty-three (83) cetaceans (whales, dolphins and porpoises), thirty-four (34) pinnipeds (seals, sea lions and walruses), six (6) sirenians (manatees and dugongs) and four (4) fissipeds (polar bears and sea otters) were presented on the integrated checklist. In addition, this paper assessed some marine mammal species that are endangered and threatened with extinction such as Monachus monachus and Phocoena sinus. Legislation, conservation and implications for the management and preservation to address marine mammals and combat the effect of climate change was also presented in this review. The published works of literature established that the global marine mammal population dynamics, ecology, reproduction, abundance and distribution are all affected by the threats of climate change. The availability of prey impacts the distribution, abundance and movement of marine mammals as well as their community structure, vulnerability to toxins and disease, success of their reproduction, and, ultimately, their survival. Additionally, marine mammals are particularly vulnerable to the possible effects and repercussions of changes in salinity, pH, and CO2. This review highlights that more extensive studies on the impact of climate change on marine mammals should be done in neotropical countries since there are gaps of such information on research and published data in these biodiversity-rich regions.
Legal research on disputes over webtoon copyrighted works
Authors:   Korea Copyright Commission, Park Jeong-in , Jeong Hyeon
Published: October 2024

The webtoon industry is one of the representative digital content fields that started in Korea and is spreading worldwide. Webtoons are a digital comic format that can be easily accessed through the Internet, and have experienced explosive growth, especially with the popularization of smartphones. Naver Webtoon and Kakao Webtoon have established themselves as representative platforms in Korea, and Naver Webtoon’s global services, such as ‘LINE Webtoon’ and ‘WebComics’, have secured an international fan base by providing webtoons translated into various languages. These platforms provide new content every day through numerous webtoon artists and works, and operate various business models that support webtoon artists’ revenue generation. Unlike comics that were intended for publication, webtoons are quickly provided to the platform by multiple people working together, and modifications are easy, so each person who contributed to the work may think that they are the copyright holder, and there have been considerable internal disputes, large and small, due to complaints about the distribution of copyright profits.
First, the disputes that frequently occur between writers and illustrators are conflicts of opinion on whether the work can be separated. The courts usually focus on whether the comic book work is plagiarized from the ‘illustrator’ work, and it is true that video producers who purchase the film rights also purchase the film rights by purchasing the character rights from the ‘illustrator’, which has left writers significantly alienated. However, it is true that it is difficult to create a webtoon if the writer does not provide the story, and the importance of a joint authorship agreement was suggested as a solution to this problem. In addition, the lack of understanding of joint works between webtoon writers and assistant writers was reexamined to examine the current Supreme Court’s attitude in the event of a copyright dispute in the future. An assistant writer who receives a service fee from a webtoon writer is interpreted in the Copyright Act as someone who helps the webtoon writer with his or her work as an assistant, not a joint author, even if he or she is currently quite capable. Therefore, in cases where the copyright of an excellent assistant writer must be separately recognized, the webtoon writer must clearly state whether or not he or she intends to co-author and write this in the contract to avoid copyright disputes with the assistant writer.
In addition, we have tried to minimize future confusion in the webtoon industry and contribute to its development by organizing disputes that may arise when secondary works are created with or without permission in webtoon works and studying the standards in advance.
Analisis Kemampuan Penalaran Matematis Siswa SMP Materi Geometri Ditinjau Gaya Kognitif Dan Tingkat Berfikir Geometri Van Hiele
Authors: Setiyawan Ahmad Heri , Fauziyah Nur , Fadholi Ahmad
Published: October 2024

Abstract
Studying geometry can develop the ability to reason or think logically to solve problems related to shape statements, size, relative position of images, and the nature of space. Mathematical reasoning is students' thinking power in concluding and is the highest mathematical cognitive domain. Middle school-level students need help in mathematical reasoning at the conclusion-drawing stage. Qualitative descriptive research to describe the mathematical reasoning abilities of junior high school students. The research subjects for class VIII A UPT SMP Negeri 22 Gresik consisted of three field-dependent cognitive style students and three field-independent cognitive style students. Analysis of research data from the results of written tests and interviews with mathematical reasoning instruments on congruence and similarity of flat shapes and the Van Hiele Geometry Test. The results of research on the relationship between stages of geometric thinking levels and indicators of mathematical reasoning ability of two level 1 students, visualization meets three indicators; two analysis level 2 students met three indicators; and two level 3 students of informal deduction abstraction met five indicators. The average mathematical reasoning ability of the five indicators only provides reasons for several solutions and cannot check the validity of an argument and draw appropriate conclusions.
Abstrak
Mempelajari geometri dapat menumbuh kembangkan kemampuan dalam bernalar atau berpikir logis memecahkan masalah berkaitan dengan pernyataan bentuk, ukuran posisi relatif gambar, dan sifat ruang. Penalaran matematis adalah daya pikir siswa dalam menarik kesimpulan sesuatu dan ranah kognitif matematis paling tinggi. Siswa tingkat Sekolah Menengah Pertama kesulitan dalam penalaran matematis pada tahapan penarikan kesimpulan. Penelitian deskriptif kualitatif dengan tujuan mendeskripsikan kemampuan penalaran matematis siswa Sekolah Menengah Pertama. Subjek penelitian kelas VIII A UPT SMP Negeri 22 Gresik terdiri dari tiga siswa gaya kognitif Field Dependent dan tiga siswa gaya kognitif Field Independent. Analisis data peneliti dari hasil tes tertulis dan wawancara instrumen penalaran matematis kekongruenan dan kesebangunan bangun datar dan Van Hiele Geometry Test. Hasil penelitian hubungan antara tahapan tingkat berpikir geometri dan indikator kemampuan penalaran matematis dua siswa tingkat 1 visualisasi memenuhi tiga indikator; dua siswa tingkat 2 analisis memenuhi tiga indikator; dan dua siswa tingkat 3 abstraksi deduksi informal memenuhi lima indikator. Kemampuan penalaran matematis rata – rata dari lima indikator hanya pada memberikan alasan terhadap beberapa solusi dan belum dapat memeriksa kesahihan suatu argumen dan menarik kesimpulan yang tepat.
Perbandingan Hasil Belajar Menggunakan Pendekatan Saintifik Dan Kontekstual Melalui Google Classroom
Authors: Setya insani Silvia alda
Published: October 2024

Skripsi ini membahas tentang perbandingan hasil belajar menggunakan pendekatan saintifik dan kontekstual melalui google classroom pada siswa kelas VIIdi MTs Masudiyah giri Gresik. Penelitian ini bertujuan untuk: 1) mengetahui bagaimana hasil belajar matematika siswa setelah diajar menggunakan pendekatan saintifik pada kelas VII-B di MTs Masudiyah Gresik, 2) mengetahui bagaimana hasil belajar matematika siswa setelah diajar pendekatan kontekstual pada kelas VII-C di MTs Masudiyah Gresik, dan 3) mengetahui apakah terdapat perbedaan yang signifikan antara hasil belajar yang diajar pendekatan saintifik dan kontekstual pada siswa kelas vii di MTs Masudiyah Gresik
Penelitian ini merupakan jenis penelitian komparatif, populasi dalam penelitian ini adalah peserta didik kelas VII di MTs Masudiyah Gresik yangterdiri dari 3 kelas yaitu kelas VII-A,VII-B, dan VII-C.sampel yang diambil adalah kelasVII-B dan kelas VII-C. dengan Teknik pengambilan sampel menggunakan sampel acak random sampling. Teknik pengumpulan data yang digunakan adalah tes. Instrument yang digunakan dalampenelitian ini adalah tes. Teknik analisis yang digunakan adalah analisis statistic deskriptif dan analisis yang digunakan adalah analisis statistika deskriptif dan analisis statistika inferensial
 Hasil analisis deskriptif menunjukkan bahwa rata-rata hasil belajar menggunakan pendekatan saintifik meningkat dari 70,93  menjadi 79,96  dan untuk rata-rata hasil belajar menggunakan pendekatan kontekstual juga mengalami peningkatan dari 70,36 menjadi 80,32. Selanjutnya hasil analisis inferensial menggunakan SPSS menunjukkan bahwa terdapat perbedaan yang signifikan antara hasil belajarmenggunakan pendekatan saintifk dan kontekstual dimana pada hasil perhitungan nilai sig = 0,00 lebih kecil dari α=0,05 (0,00<0,05) yang berarti Ho diterima
Analysis of Chemical Components and Antioxidant Activity in Nutmeg Shell Liquid Smoke Processed through Rotary Evaporator Purification
Authors: Watuseke Rommy David , Gugule Sanusi , Lombok Johny Z
Published: October 2024

This study aims to analyze liquid smoke's chemical content and antioxidant activity from pyrolysis of nutmeg (Myristica fragrans) shell with rotary evaporator purification. A rotary evaporator purified liquid smoke from the pyrolysis of nutmeg shells. Identification of the chemical components of liquid smoke from the pyrolysis of nutmeg shells was carried out by Gas Chromatography-Mass Spectroscopy (GC-MS), and Antioxidants were measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with absorbance at a wavelength of λ 517 nm. The results of GC-MS analysis showed 14 peaks and 19 types of compounds detected with the 2-methylphenol compound component located at a retention time of 4.974 minutes, standing out with the largest contribution in terms of area, reaching 47.74%. The antioxidant test showed that the nutmeg shell has IC50 values before and after rotary evaporation of 0.40% and 0.07%, having strong antioxidant activity, and the results at a concentration of 3.2 mg/ml provided a level of free radical protection of more than 50%, namely 91.14%. The main compounds that play as antioxidants are phenol compounds and their derivatives, such as 2-methoxy-phenol  and 2-methoxy-4-methyl-phenol.
Characterization of HCl-activated Water Hyacinth (Eichhornia crassipes) Adsorbent in Removing Lead Ion (Pb2+) from Battery Industry Effluent
Authors: Utami Wasistianna , Sari Dessy Agustina , Wahyuningtyas Aulia
Published: October 2024

This study utilizes the adsorption process to reduce the concentration of lead ions in battery industry wastewater by using adsorbents from water hyacinth (Eichhornia crassipes). This research aims to determine the ability of a bioadsorbent activated by a 0.1 M HCl solution to adsorb Pb2+ through FTIR and AAS characterization. The bioadsorbent was contacted into a standardized solution of Pb2+ with varying contact times (viz., 20, 30, 40, 50, 60, 70, 140, 210, and 280 to determine the maximum adsorption). The highest absorption of the Pb2+ in battery industry wastewater took place for 210 minutes. The absorption ability was 94.45%, with 8.1488 ppm as the initial concentration. Then, this study shows that this characterization before the activation of 0.1 M HCl has O-H, C-H, C=O, and C-O ether functional groups. All three identified the presence of cellulose. Post-activation, lignin, and hemicellulose disappeared due to the vibration of the C=O group. However, an increase in the intensity of the vibrational peak at the C-O group indicates the presence of carbon chain linking in cellulose. Finally, after contact with battery industry effluent, bending vibrations were lost because the H atoms in the functional groups had been substituted with Pb2+.
Radioisotope 32P for Keloid Therapy: A Review
Authors: Rahman Wira Y , Budiawan Budiawan , Suseno Heny
Published: October 2024

Keloids are skin disorders resulting from an abnormal wound healing response, often leading to excessive scar tissue growth. Keloids can be itchy, painful, and aesthetically disturbing. Keloid therapy varies, but until now, there is no standard method that is effective due to different patient responses. Racial, environmental, and genetic variables influence keloids. Various therapeutic techniques, such as surgery, cryotherapy, corticosteroid injections, laser light, and radiotherapy, have been used to treat keloids, but each has advantages and disadvantages. However, these treatments have limitations, such as high recurrence rates and patient discomfort. The application of radioisotope therapy, specifically using 32P, has emerged as a promising alternative. Radioisotope 32P emits β-particles, effectively inhibiting keloid cell growth by causing DNA damage and reducing collagen production. Studies show that 32P therapy significantly reduces keloid size and recurrence rates while causing minimal patient discomfort. Although there are potential risks, such as damage to surrounding healthy tissue, 32P therapy provides a practical and non-invasive option for keloid management. However, more research is required to fully understand this method’s effectiveness, safety, and long-term impact on keloid therapy, optimize treatment protocols, and minimize side effects.
Penyusunan Laporan Keuangan pada Yayasan Bundo Saiyo
Authors: Roskha Riza Meilani , Ferdawati Ferdawati , Ahmad Afridian Wirahadi , Sulastri Reni Endang
Published: October 2024

The final report is to comprise the financial report of the Bundo Saiyo Foundation according to the general standard of financial accounting. The creation of financial statements is set by Statement of Financial Accounting no. 1 (PSAK 1) and for non-profit entities set in the Standard Interpretation of Financial Accounting no. 35 (ISAK 35). The foundation is one form of a nonprofit entity that is primarily moving toward humanity with the primary goal of not making profit. The final research object for this project is the Bundo Saiyo Foundation, which is located at the Balai Gadang, Koto Tangah district, Padang City, West Sumatra. The Bundo Saiyo Foundation has not yet compiled a financial report and has only a record of cash in and cash out, so the true value of assets, liabilities and assets is unknown. The study results in a financial report composed of comprehensive income statements, statement of changes inn equity, financial position statements and cash flow statements. With the financial report expected transparency and accountability to the Bundo Saiyo foundation.