bluuebunny/crossref_metadata_2025 huggingface dataset:
Curative Effect of the Butanol Fraction of Root Bark of Gardenia gummifera L.f against N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Experimental Rats
Authors: Dwaraiswami Suma , Nair Raji R. , Mukalel Sankunni Latha
Published: July 2024

Gardenia gummifera Linn. f. belongs to the family Rubiaceae, which is found in rocky hilltops, widely used in traditional medicine. As the plant is rich in active phytoconstituents, there is immense scope for future researches that targeted the studies on experimental animals against various ailments that have been entertained. Curative efficacy of butanol fraction of ethanol extract of root bark of G. gummifera L.f was evaluated on N’Nitrosodiethylamine induced hepatocellular carcinoma in experimental rats. The curative efficacy of two doses of G. gummifera butanol fractions (100 mg/kg bw and 200 mg/kg bw) was evaluated against NDEA induced liver cancer in male Wistar rats. At the end of the experiment, animals were sacrificed and the percentage of nodule incidence and all biochemical parameters, including liver cancer markers were analyzed along with histopathological investigation in the experimental animals. The rats treated with butanol fraction of ethanol extract of Gardenia gummifera L.f root bark (BUGG) remarkably repressed the NDEA-induced increase of hepatic nodule incidence, nodule multiplicity, serum biochemical indices. They improved the normal hepatocellular architecture in the toxic group. Also, the biochemical analysis of treated groups revealed that BUGG neutralizes NDEA-induced oxidative stress by restoring antioxidant enzymes. In NDEA administered rats the decreased concentration of proliferative marker, alpha fetoprotein (AFP) was observed upon the supplementation of BUGG. Notably, 200 mg/kg bw BUGG supplementation showed better results than the standard drug-treated group. These results might be linked with the improvement of antioxidant activity and inhibition of hepatic cell proliferation. The conclusions of the present investigation highlight the curative effect of BUGG against the chemical carcinogenesis model and the study suggests that BUGG can be a promising source of chemopreventive, HCC inhibiting agent.
Development and Validation of Tafenoquine by HPLC Technique along with stress degradation study of Tafenoquine
Authors: Tekade Mayur Sanjay , Patil Pallavi Mangesh , Chopade Vitthal V. , Agarkar Samiksha Surendra
Published: July 2024

The most prevalent parasite disease in humans is malaria. According to estimates, 3 billion individuals worldwide are at danger of developing this illness. For the quantitative detection of tafenoquine, a brand-new, quick, and accurate stability-indicating high performance liquid chromatographic method was created and validated. On an Inertsil ODS-3V column (150 mm 4.6 mm, 5.0 m) with mobile phase methanol and water (80:20) at a flow rate of 1 mL/min, effective chromatographic separation was accomplished. The analyte was seen using a photo-diode array detector at a wavelength of 254 nm. Tafenoquine was subjected to acidic, basic, oxidative, thermal, and photolytic conditions in order to force its destruction. The peaks of the degradation products produced were distinct from those of tafenoquine and showed the specificity and stability of the technique. The method was also validated using criteria like specificity, precision, linearity, accuracy, and robustness in accordance with the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. The major goal of this research was to create a fast, sensitive, and stable HPLC method for analysing and assessing the purity and stability of tafenoquine in formulations.
Comparative Study of Anti-Inflammatory Activity of Two Formulations of Jatyadi Thailam In Vitro on Raw264.7 Macrophages and its Dual Inhibitor Role of 5-Lipoxygenase and Cyclooxygenase
Authors: Swathi Kandasamy , Sumathi Sundaravadivelu
Published: July 2024

Jatyadi thailam is traditional formulation widely used to treat chronic wounds. Reverse pharmacology approach is employed to study the mode of action of two traditional formulations of thailam-AFI Jatyadi thailam (JT-AFI) and Jatyadi thailam-Yogagrantha (JT-YG) against radicals DPPH, ABTS, Nitric oxide, hydroxyl, and superoxide radicals and inflammatory mediators in vitro, namely Nitric oxide, 5-Lipoxygenase and cyclooxygenase-1, and cyclooxygenase-2. Both formulations of Jatyadi thailam rendered dose-dependent inhibition of free radicals and demonstrated their reduction potential.. The free radical formation is inextricably associated to the inflammatory process. The formulations significantly reduced nitrite at its highest concentration in LPS-induced RAW264.7 macrophage cells. The formulations also unveiled subsequent dose-dependent inhibition of 5-Lipoxygenase, Cyclooxygenase-1, and Cyclooxygenase-2 enzymes. JT-AFI proved to be a selective inhibitor for COX-2 with a COX-1/COX-2 ratio of 1.924, while JT-YG was COX-1 selective (0.794). The study's outcome indicated that JT-AFI exhibited superior antioxidant and anti-inflammatory activities than JT-YG. The current investigation could shed insights on the scientific validation of the use of Jatyadi thailam in chronic wound management.
Cardioprotective Effect of Hibiscus Syriacus Extract on Isoproterenol Induced Myocardial Infarction in Rats
Authors: Bhadore Narendra Singh , Das Prabhat Kumar , Pillai Sujit
Published: July 2024

The present research was designed to evaluate the cardio-protective role of chronic oral administration of Hibiscus syriacus flower extract against Isoproterenol-induced myocardial injury in rats and to compare it with α-tocopherol, a known cardioprotective antioxidant. Male Wistar albino rats were randomly divided into five groups (n = 6) and treated as per treatment protocol with two different doses of Hibiscus syriacus Methanolic extract (250 and 500 mg/kg body weight) 6 days per week for 4 weeks. At the end of the treatment, all the rats (except control rats) were administered with Isoproterenol (85 mg/kg) for two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group II) induced oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Hibiscus syriacus extract in all two doses (group III, and IV) shows a protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD), and catalase). In Hibiscus syriacus treated groups significant increase (p<0.001) of LDH in heart homogenate and a decrease of SGOT and LDH in serum were observed. Microscopic studies in ISO-treated animals revealed mitochondrial swelling, leukocyte infiltration, lipid inclusions, and myofibrillar loss whereas the pre-treatment with Hibiscus syriacus led to a lesser degree of ISO-induced histological alterations. The extract effect was compared with the reference standard α‑tocopherol which also offered similar protection in biochemical and histopathological changes. Thus, the study shows that Hibiscus syriacus Methanolic extract exhibits significant antioxidant activity and protects the heart from free radical-mediated toxicity of Isoproterenol.
Evaluation of anti-asthmatic activity of aqueous extract of bark of Prosopis cineraria (L.) Druce against milk induced leukocytosis and eosinophilia
Authors: Khatri Anirudh , Rathore Anita , Fenin Vikas , Jain Chandra P.
Published: July 2024

The present investigation was conducted to evaluate the anti-asthmatic activity of aqueous extract of the bark of Prosopis cineraria (L.) Druce to validate its traditional and ethnopharmacological use. Aqueous extract of the bark of P. cineraria (L.) Druce at doses of 100 and 200 mg/kg b.wt i.p was evaluated for the assessment of its anti-asthmatic activity using milk induced leukocytosis and eosinophilia, oxidative stress analysis in the liver and kidney, along with histopathological changes in the trachea of mice. The results of the present investigation showed that aqueous extract of bark of P. cineraria at (100 and 200 mg/kg b.wt, i.p) significantly decreased milk induced leukocytosis and eosinophilia, was effective towards restoration of enhanced levels of lipid peroxidation and reduced levels of GSH and SOD in the liver and kidney, and showed a reduction in the thickness of the tracheal wall and cartilage along with inflammatory cells in mice in a dose-dependent manner when compared with the control group. It can be concluded that aqueous extract of the bark of P. cineraria (L.) Druce possesses anti-asthmatic activity.
Development and Optimization of Apixaban Loaded Solid Lipid Nanoparticles by Central Composite Design, in vitro and ex vivo Characterization
Authors: Konatham Suresh , Patangay Shashikala
Published: July 2024

The study’s objective is to develop apixaban-loaded solid lipid nanoparticles (SLN), which provide an increased permeability and sustained release compared to tablet formulations. The design of experiments (DoE) is employed in the development and optimization of SLNs. SLNs were manufactured using hot homogenization followed by an ultra-sonication method. Initially, screening of lipids and surfactants (both qualitative and quantitative variability) was done by mixture design. Furthermore, the formulation was optimised using central composite design considering the concentration of both lipid and surfactant as factors and particle size, polydispersity index (PDI), encapsulation efficiency (EE), zeta potential, and percent drug release as responses. Statistical evaluation was performed to get the optimised formulation composition, i.e., glyceryl monooleate (GMO) -6.7% and polysorbate 80-3%. The surface morphology has shown that the SLNs were spherical with a particle size of 239.33 ± 10 nm, PDI of 0.135 ± 0.015, EE of 78.00 ± 2% and zeta potential of -26.4 ± 0.75 mV. %drug release from the optimised formulation was extended to 24 hours. In-vitro release showed the initial burst release was followed by a persistent release lasting up to 24 hours. The ex-vivo permeation studies revealed that the permeability of the optimised SLN formulation is increased by 1.9 and 1.3 times compared to pure drug and tablet formulations. The stability results showed that the optimised formulations were stable for up to 6 months at 2–8℃ and 25 ± 5℃/60 ± 5% RH. These findings suggest that the apixaban SLNs could be used as a delivery system with higher bioavailability and longer drug release.
Synthesis and Evaluation for Anxiolytic activity of some substituted Dihydropyrazolyl- thiazoline-4-one derivatives
Authors: Rishipathak Dinesh , Raut Manisha
Published: July 2024

Anxiolytic drugs are used for the treatment of anxiety disorders and their related psychological and physical symptoms. Today's increase in anxiolytic drug resistance has resulted in serious health issues. Thus, there is an ever-increasing demand for the design and synthesis of newer drugs for treatment. The present work reports the synthesis of some derivatives of pyrazolyl thiazolino-4-one viz. 2-[3-(furan-2-yl)-5-substituted phenyl-4,5-dihydro-1H-pyrazole-1-yl]-1,3-thiazole-4(5H)-ones. Six derivatives have been synthesized and the chemical structures were confirmed by IR, H1-NMR, and 13C-NMR. All the compounds were subjected to toxicity studies and then evaluated for their anxiolytic activity using elevated plus maze apparatus on rats.  LD50 was found to be 98.11 mg/Kg. An increase in the percentage of time spent and the number of entries in the open arm of the plus maze signals a good potential for minimizing anxiety in rats. All the results were statistically tested by one-way ANOVA followed by Dunnett’s test. Compound 2; 2-[3-(furan-2-yl)-5-(4-dimethylamino- phenyl)- 4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one and Compound 5; 2-[3-(furan-2-yl)-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one have shown percentage preference to open arm as 15.11 and 14.17 seconds and average time spent in open arm as  45.33 and 42.50 seconds respectively and thus resulted in significant anxiolytic effect as compared to control. These compounds can serve as potential leads for the development of newer therapeutic agents for the treatment of anxiety.
Molecular Docking and Pharmacokinetic Studies of Some New pyridyl and hydrazinyl bearing thiazole Derivatives as Potential DNA gyrase Inhibitors
Authors: Kumar Ajay , Priyanka  , Gaba Parmina , Goyal Anju
Published: July 2024

An essential bacterial protein called DNA gyrase is involved in transcription and replication and stimulates the negative super-coiling of the circular DNA found in bacteria. Since its inhibition causes bacterial mortality, DNA gyrase is a well-known target for antibacterial drugs. Gyrase is inhibited by quinolones, coumarins, and cyclothialidines. The objective of the present study is to evaluate the binding interaction of pyridyl and hydrazinyl-bearing thiazole compounds with DNA gyrase inhibitors and also check the ADME properties of all compounds. We performed docking and pharmacokinetic studies of 28 novel hypothetical compounds. Interacting amino acids of receptor DNA gyrase with reference drug prothionamide were VAL 167, VAL 71, ILE 78, and THR 165 and binding affinity was found to be -5.61 kcal/mol. Most of our docked compounds also show interaction with amino acids VAL 71 and ILE 78 with superior binding affinity. Molecular docking suggests that all the synthesized derivatives have shown higher level binding affinity in contrast to standard drug prothionamide and have an acceptable range of ADME properties.
Synthesis and Evaluation of Antibacterial and Antifungal profile of some Newer Isoxazole Analogous
Authors: Verma Hritik , Singh Umakant , Pathak Devender
Published: July 2024

A new series of 5-(chloromethyl)-3- (substituted phenyl) isoxazole was synthesized in the presence of sodium hydroxide, substituted aromatic aldehyde (1) combine to produce oxime(2), which are then cyclized in the presence of dichloromethane, triethylamine, & N-chlorosuccinimide to develop Compound (3) and on chlorination onward 5-(chloromethyl)-3- (substituted phenyl) isoxazole (4). By employing IR, 1H-NMR, mass spectral, and elemental analyses, the chemical compositions of the generated molecules were verified. The developed molecules were tested for their antibacterial properties (E. coli & S. aureus), antifungal (A. niger & C. albicans). The new compound demonstrated considerable antibacterial and antifungal activity on level with standards set.
A Novel Approach for the Treatment of Hypertension: Gastroretentive Microballoons of Atenolol
Authors: Detholia Krunal , Patel Parth , Varia Umang , Katariya Hitesh , Jadeja Mukesh
Published: July 2024

The formulation of atenolol-loaded microballoons involved the use of Eudragit RS 100, HPMC K4 M as a polymer, and span 80 as a surfactant. The microballoons were prepared by an emulsion solvent diffusion (non-aqueous) using liquid paraffin, methanol, and dichloromethane as a processing medium. The Box-Behnken design was utilized to get optimized formulation using a concentration of HPMC K4 M (A), Concentration of Eudragit RS 100 (B), Concentration of surfactant (C), and stirring speed (D) as an independent parameter while, Particle size (Y1), entrapment efficiency (Y2) and %buoyancy (Y3) using as a dependent parameter. For the optimised formulation, the mean particle size was 85.878 ± 1.063 μm, entrapment efficiency was 92.26 ± 1.65%, and buoyancy was 89.19 ± 1.48% found. An image of the formulation taken using a scanning electron microscope (SEM) reveals discrete particles with a smooth surface texture, a hollow interior, a spherical shape, and a particle size of less than 200 μm. The FTIR study confirms there was no interaction between the drug and excipients. The in-vitro drug release study found that atenolol-loaded microballoons released the drug for up to 12 hours as compared to the pure drug. This was due to increasing the gastric residence time and absorption area in the stomach. The drug release kinetic study reveals that it follows the Higuchi model and the drug release mechanism was type II transport which was obtained from the Korsmeyer Peppas model. The stability study shows that there is no significant change in the optimized microballoons for 30 days as per ICH guidelines.
Synthesis and biological evaluation of some novel quinoline derivatives bearing pyrazole moiety
Authors: Kumar Ram , PATHAK DEVENDER
Published: July 2024

Reported herein are the design, development and investigation for antibacterial and antifungal studies of a novel series of substituted quinoline analogues bearing pyrazole moiety. Acetanilide derivatives were prepared from the reaction of various anilines with acetyl chloride. Cyclization of these acetanilide derivatives (Vilsmeier-Haack reaction) using phosphorus oxychloride and dimethyl formamide afforded corresponding 2-chloroquinoline-3-carbaldehyde compounds (1a-1l). Titled molecules were synthesized through treatment of 1a-1l with hydrazine hydrate to afford corresponding 1H- pyrazolo [3,4-b] quinolines (2a-2l). All the synthesized analogues were recrystallized and characterized through FTIR, 1H-NMR and mass spectroscopy. All analogues were screened for antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria while antifungal activity against Candia albicans, and Aspergillus niger by disc diffusion method. Compounds 2c, 2e, 2h, 2k, and 2l exhibited promising antibacterial and antifungal activity when compared with standard drugs ciprofloxacin and fluconazole, respectively. Thus, these studies suggest that quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antibacterial and antifungal agents.
Combined Antidepressant Effect of Acetyl-L-Carnitine and Bupropion against Experimental Animal Model
Authors: Padhy Jagamohan , Samal Pradeep Kumar , Choudhary Rajesh , Shree Jaya , Vaishnaw Bharti
Published: July 2024

Depression is one of the most common mental diseases characterized by mood disorders affecting around 322 million individuals in the world. Depression is a feeling of inadequacy, dejection, anhedonia, and decreased activity in any action. Previously acetyl-L-carnitine reported beneficial effects on lipid metabolism, neuroprotection, and some types of depression. Therefore, in the present study, we evaluated the combined effect of acetyl-L-carnitine and bupropion against experimental-induced depression. Albino rats were divided into different groups (each group contained six animals). Normal groups received saline (1 mL/kg, i.p.). The standard group received imipramine (20 mg/kg, i.p.). The ALC group received acetyl-L-carnitine (100 mg/kg, i.p.), and the BPR group received bupropion (20 mg/kg, i.p.). T I and T II groups received acetyl-L-carnitine (30 mg/kg, i.p.) + Bupropion (10 mg/kg, i.p.) and acetyl-L-carnitine (80 mg/kg, i.p.) + Bupropion (30 mg/kg, i.p.), respectively. Antidepressant effects were assessed by forced swim test and sucrose preference test. In both models, the combined effect of the drug produced a significant (p < 0.05) antidepressant action as compared to the depression control group. Based on the findings, the combined effect of acetyl-L-carnitine and bupropion had a better therapeutic effect to combat depression as compared to individual treatments.
Characterisation and Cytotoxicity Analysis of Green Synthesised Silver Nanoparticles Using Fruit Peel Extract of Citrus pennivesiculata (Lush.) Tanaka
Authors: George AKHILA , P. T. Sheba , Joseph Elsam
Published: July 2024

Silver nanoparticles were green synthesized using the aqueous extract of Citrus pennivesiculata (Lush.) Tanaka, J. fruit peel. The metallic silver was reduced to silver nanoparticles by the action of secondary metabolites in the fruit peel. The characterization of silver nanoparticles was done by UV-visible spectrophotometry, transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). UV-vis spectrophotometry of the silver nanoparticles showed an absorption peak at 435 nm. The TEM analysis showed that the spherical diameter of the particle ranged between 2 to 34 nm. The XRD analysis proved the crystalline nature of the synthesized silver nanoparticles. The FTIR analysis of the synthesized nanoparticles showed the presence of alcohols, phenols, aromatic esters, monosubstituted alkynes, disubstituted alkenes, sulfoxide, amino, and other functional groups. Cytotoxicity and anticancer activity of the green synthesized silver nanoparticles were determined using the mouse fibroblast cell line (L929) and human breast cancer cell line (MCF-7), respectively. The lethal concentration (LC50) of silver nanoparticles on the L929 cell line was found to be 48.521 μg/mL, and that of the MCF-7 cell line was 21.625816 μg/mL. The synthesized silver nanoparticles revealed cytotoxic activity in a dose-dependent manner. The conclusions drawn from this research could be beneficial for nanotechnology-based biomedical applications.
EFL Students' Challenges in Pronouncing Inflectional Suffixes: A Case Study of Socotri Students of English
Authors: Hamdeen Sina Bin , Al-Rajdhi Fatima , Majid Amna Bin , Al-Jerbhi Asmaa , Al-Rajdhi Latifa
Published: July 2024

This study aims to measure the proficiency level of Socotri EFL students in pronunciation of inflectional suffixes, /d/ and /s/. Quantitative data were collected through a test from a group of 24 English language students from the first and second levels at the College of Education, Humanities and Applied Sciences in Socotra. The results of the study showed that the students scored accepted in the pronunciation test with 61.92%. Results also showed that Socotri students suffer from difficulty in pronunciation, especially in the suffix /d/ more than /s/. The study also found differences in students' scoring in the tests in which male students scored (M=23.37) higher than female students (M=20.12) and second level (M=23.72) scored higher than first level (M=21.07), but they were not significant. The study recommends EFL teachers to focus on the practical aspect rather than the theoretical aspect while teaching pronunciation and speaking and listening skills. We also recommend choosing teachers who are fluent in English language teaching.
An Analysis of WhatsApp Interactions Among Youth: A Case of Language Attrition
Authors: Shubhra Shubhra , Krishna Devina
Published: July 2024

This study delves into the intriguing world of language dynamics within the popular messaging platform, WhatsApp, focusing on how young people communicate. Through the course of its research, this study aims to uncover a fascinating phenomenon called ‘Language Attrition’ - a subtle transformation in the way languages are used in this digital space. On WhatsApp, users seamlessly blend their native languages with a more global one. This results in a unique linguistic landscape where expressions from different languages coexist, sometimes making it challenging to distinguish between them. With India being a multilingual nation, the study explores the potential loss or degradation of languages due to the leniency and carelessness of social media language. The paper employs a mixed-method approach, combining qualitative analysis of WhatsApp conversations with a digital questionnaire survey. The research investigates factors such as the prevalence of emoticons, code-switching, and multilingualism, shedding light on the multifaceted dimensions of language attrition. The research investigates factors such as the prevalence of emoticons, code-switching, and multilingualism, shedding light on the multifaceted dimensions of language attrition. The insights aim to prompt one to perceive language attrition not merely as an academic curiosity but as a catalyst for proactive measures.
Politik Dinasti Dari Perspektif Demokrasi dan Hak Warga Negara Dalam Pemilihan Umum Di Indonesia
Authors: Marwenny Elwidarifa , Syafwar Robi , Permata Gitra
Published: July 2024

The implementation of democracy in Indonesia is a mandate from the provisions of Article 2 paragraph (1) and Article 6A paragraph (1) of the 1945 Constitution of the Republic of Indonesia, where one of the indicators is general elections. However, the implementation of general elections is often overshadowed by the presence of family members of powerful politicians running for general elections and succeeding, including the elections for president, governor, regent, and others. This condition can trigger much debate and concern about democracy, the quality of elections, and political stability in Indonesia. Nevertheless, the right to elect and to be elected are protected rights and their existence is recognized by the constitution. The limitations of the problem in this paper include: 1) Political dynasty in the perspective of democracy; 2) Political dynasty in the perspective of democracy and citizens' rights in elections in Indonesia. This research used a normative juridical approach by using secondary data in the form of literature studies so that the conclusions are obtained that: a) political dynasty is contrary to democratic principles that emphasize transparency, accountability, and fair participation; b) although the regulations have been set up to protect citizens' rights to elect and be elected, the rise of political dynasty shows incompatibility with democratic principles. It is difficult to avoid political dynasty in a democracy, but efforts are needed to maintain balance and avoid abuse of power by the ruling family.
Implikasi Undang – Undang Nomor 1 Tahun 2022 Terhadap Keberadaan Pajak Daerah Sebagai Sumber PAD Kabupaten/Kota di Provinsi Sumatera Barat
Authors: Fithrina Hendria , Gusminarti Gusminarti , Darnis Darnis , Kurniawan Fajri
Published: July 2024

The implications of Law Number 1 of 2022 concerning Financial Relations between the Central Government and Regional Governments, are improvements to Law Number 28 of 2009 concerning Regional Taxes and Regional Levies. In Law Number 1 of 2022, there are changes to the components of regional tax types in districts/cities in Indonesia, one of the aims of which is to increase the regional PAD. The seriousness of the Regency/City Government in implementing the regulations in this Law will be very beneficial for regional income from the tax sector. For this reason, research was carried out on the following problems: First, what is the regional government's view of the implications of Law Number 1 of 2022 in West Sumatra? Second, how is the implementation of Law Number 1 of 2022 regarding the existence of Regional Taxes in West Sumatra? Third, what are the obstacles faced and the solutions implemented in implementing Law Number 1 of 2022 in West Sumatra? To answer the research focus, this research uses empirical juridical research methods with research specifications from the West Sumatra Bapenda, Padang City Government Bapenda and West Pasaman Regency Bapenda, and is analyzed through literature review and data analysis methods using qualitative-juridical. A number of stages must be carried out by the government, such as completing the drafting of implementing Regional Regulations as intended in the a quo statutory regulations, conducting regional potential studies with consultants to determine the potential for regional tax revenue in the Regency/City, then carrying out socialization to the community as mandatory taxes, as well as technical guidance to tax collector employees within the Regional Government Organization (OPD) in order to maximize the potential of regional wealth in Regencies/Cities in West
Impartial Law Enforcement By The Indonesian Criminal Justice System In The Civil Law System
Authors: Sari Nani Widya , Ekawati Dian , Prayitno Isnu Harjo , Munalar Sri Siti , Purgito Purgito
Published: July 2024

This writing aims to understand law enforcement by the existing criminal justice system and to understand the existing legal system models in the world and Indonesia along with their characteristics. The method used in this writing is normative legal research through literature study with data collection methods in the form of secondary data. The results of the research show that law enforcement has not been implemented optimally, so it is very important that the existing criminal justice system can work well to create and realize a sense of justice in society. In this world, there are two models of the rule of law concept that have been developed, namely the Continental European model called rechstaat and the Anglo Saxon model called the rule of law. The concept of rechtsstaat was born from a struggle against absolutism so that it is revolutionary in nature. The concept of rechtsstaat relies on the Continental Law system called civil law. Meanwhile, the concept of the rule of law develops evolutionarily, which is based on a legal system called common law.
Bankruptcy Legal System Reform in Settlement of Debtors’ Debt According to the Bankruptcy law
Authors: Basri Herlina , Santiago Faisal , Zuwanda Rifka , Yusuf Hudi , Samiyono Sugeng
Published: July 2024

According to Law No. 37 of 2004, bankruptcy is the complete seizure of a bankrupt debtor's assets, with the curator managing and settling them under the watchful eye of a supervising judge. There are several conditions for a debtor to be declared bankrupt, including having two or more creditors and not being able to make payments of at least one debt that is due and collectible and can be at his request or the request of one or more creditors. This article discusses the principle of distributing the debtor's assets if a debtor is declared bankrupt. According to Bankruptcy Law Regarding creditor provisions, in bankruptcy, three creditors are guaranteed compensation; the first is a separatist creditor, namely the creditor holding a material guarantee, then the preferred creditor, who has the right to precede because of the nature of his receivables by law is given a special position, and the last is a concurrent creditor—specifically, creditors who do not fall under the categories of favored and separatist creditors. After Article 2 paragraph (1) is explained, it is determined that creditors are concurrent, separatist, and preferential. Separatist and preferred creditors can apply for a declaration of bankruptcy without losing collateral rights to their assets on the debtor's assets and their right to take precedence. The debtor’s assets will eventually be distributed by the portion of the amount of the creditor's credit. This bankruptcy principle means that the debtor's property is jointly guaranteed for all creditors divided according to the principle of balance or “Pari Pasu Prorata Parte”
Konfigurasi Politik UU Cipta Kerja, Dan Implementasi Putusan MK Nomor 35/PUU-X/2012: Masa Depan Kedaulatan Atas Penguasaan Hutan Adat
Authors: Gusman Delfina , Raspati Lucky
Published: July 2024

This paper aims to describe the implications of the legal-political configuration of the Job Creation Law and the implementation of Constitutional Court Decision Number 35/PUU-X/2012. The data used in this study are legal materials in the form of writings published by previous researchers related to the object of this study, and materials in the form of laws and Constitutional Court decisions. These primary and secondary materials will be analyzed and interpreted qualitatively. This study finds that the Job Creation Law is an orthodox legislation formed by an authoritarian political configuration that has undermined the mandate of Constitutional Court Decision Number 35/PUU-X/2012 and has implications for the constitutional rights of customary law communities by revoking their constitutional rights over their customary forests.
IMPLIKASI KKN NUSANTARA KOLABORASI ANTAR PERGURUAN TINGGI KEAGAMAAN DALAM MENJAGA MUTU TOLERANSI DI DUNIA PENDIDIKAN
Authors: Dewa_permana21 I Dewa Gede Darma Permana
Published: July 2024

The year 2022 has been proclaimed as the year of tolerance by the Ministry of Religious Affairs of the Republic of Indonesia. To support this discourse, there is a new cooperation program carried out by religious universities called KKN Nusantara Collaboration. This collaboration program is carried out by I Gusti Bagus Sugriwa State Hindu University Denpasar, Syarif Hidayatullah State Islamic University Jakarta, and Walisongo State Islamic University Semarang to provide space for students to serve the community by promoting tolerance. Referring to this collaboration, researchers have an interest in examining the implications of the 'KKN Nusantara Collaboration' program. This study formulates three problem formulations, namely the urgency of tolerance in Indonesian education, the form of work programs in the 'KKN Nusantara Collaboration' and finally the implications in maintaining the quality of tolerance in education. Choosing qualitative research with a phenomenological approach, as well as collecting data through literature studies and having Miles and Huberman Interactive data analysis techniques, this study shows the results of the content and discussion that, the 'KKN Nusantara Collaboration' program is the answer to the urgency of cultivating tolerance in Indonesian education. The 'KKN Nusantara Collaboration' program can be made in the form of several activities, including the introduction of holy places, preservation of regional culture, socialization of religious moderation, and celebration of Independence Day. All of these activities have a positive impact in maintaining the quality of tolerance.
MENELUSURI PERAN DAN TANTANGAN PROGRAM GURU PENGGERAK DI SEKOLAH DASAR
Authors: Prasetyo Teguh , Putria Gadies Shelly , Wudda Rikza Fauziyah , Talaar Vania Salsabila
Published: July 2024

Major challenges in education in Indonesia include the complexity of the curriculum, frequent changes, and the placement of teachers according to their expertise. To overcome this, the government launched the Teacher Mover (Guru Penggerak) in schools program as part of efforts to implement the independent learning curriculum. This program aims to obtain an overview of the implementation of the driving teacher program in schools regarding the role of the program, training activities, obstacles and benefits. Qualitative descriptive research was analyzed thematically with the help of the NVivo 12 application. The results were found to focus on driving teachers as leaders in learning and creative teachers. The subfocus of training and mentoring activities found interesting indicators such as program evaluation, providing mentoring, managing the quality of activities, and solving program problems. Next, the sub-focus of obstacles and challenges will be discussed in depth in this scientific article. Therefore, this research innovates the mover teacher program in schools as an innovation in the field of education, with a focus on the role of mover teacher programs, schools, government and society.
E-MODULE INTERAKTIF BERBASIS FLIPBOOK PADA MATAKULIAH MACHINE LEARNING UNTUK MENINGKATKAN KREATIFITAS MAHASISWA
Authors: Nonik Erawati Kadek , Dita Ardiani Ni Nengah , Santiago Gede Agus Santiago
Published: July 2024

This flipbook-based interactive e-module aims to increase student creativity in the Machine Learning course. This module thoroughly explores basic concepts, algorithms, and practical applications in Machine Learning. The research method involved developing an engaging and interactive learning platform with features such as quizzes, video tutorials, and mini-projects. The research results show increased student engagement and understanding of Machine Learning concepts. This e-module can encourage creative approaches to solving problems. The conclusion highlights the importance of interactive e-modules in boosting creativity and practical learning in Machine Learning education, especially based on digital flipbooks; users can enjoy a more dynamic and interesting learning experience through images, graphs, and other visual elements. Using digital flipbooks, they can enjoy a more dynamic and engaging learning experience through the use of images, graphs, and other visual elements.
BATU PULAKI AND ITS IMPLICATIONS FOR THE LIVES OF BALINESE PEOPLE
Authors: Eka Suadnyana Ida Bagus Putu , I Nyoman Miarta Putra
Published: July 2024

Batu Pulaki is a stone that is a manifestation of Bali's natural wealth as well as a heritage in the cultural life of the people of Bali. Knowledge of the types, contents, functions and their relationship with the people in Bali. This study aims to describe in more detail the Batu Pulaki its implications for the lives of Balinese people context of the people of Bayupoh Village. To explain the problem above the author uses a type of qualitative research. In this case, the authors were directly involved in data collection by means of observation, documentation, and interviews with informants in the Pulaki area of Bali. In addition, this research uses types of library data such as books, theses, journals, internet media, and so on that supports research. To answer the problem, researchers used Structural Functional Theory. From the research conducted, the findings were obtained, namely the existence of Pulaki stones in a sacred area in which there is the Agung Pulaki temple and several Pasanakan temples around the Pulaki temple. This shows that the Pulaki region with several temples there as relics of Hindu civilization is a center of social and spiritual activity. Pulaki as a sacred area and Pulaki stone as a symbol of community religious ritual facilities historically and theologically provide an aid in understanding religion to the community. The people of Banyupoh Village use Pulaki stones for pedagingan and panca datu, apart from that the existence of Batu Pulaki is also used as a shrine, as a medium of worship by the Hindu community in Banyupoh Village. In its innovation and development, Pulaki stone has been transformed into several art products such as accessories, water fountains and various types of sculptural art.
BALINESE ACTIONS AND SOLIDARITY REGARDING OGOH-OGOH IN BANJAR UNTAL-UNTAL: A SOCIOLOGY OF RELIGION PERSPECTIVE
Authors: Nole Otniel Aurelius
Published: July 2024

Ogoh-ogoh is a typical Balinese activity that can be found once a year. Ogoh-ogoh is characterized as a sculptural artwork resembling a creepy creature’s image as it symbolizes bhuta kala as an evil entity. Balinese people celebrate the ogoh-ogoh parade, burn them to avoid negative influences and continue life with silence and positivity in the Saka New Year (Nyepi). Ogoh-ogoh is also a tradition that attracts attention because it is displayed with the splendor and beauty of stunning artwork. Of course, it reflects the behavior of Balinese people, whom residents of Banjar Untal-Untal also celebrate. The purpose of this research was to analyze the actions and solidarity of Balinese people regarding ogoh-ogoh in Banjar Untal-Untal from the perspective of the sociology of religion. This research method was qualitative with a case study design. The researcher collected data through interviews and observation. This research showed that the preparation, making, and implementation of ogoh-ogoh exists because of the involvement of people who act in solidarity. Max Weber’s theory of social action and Emile Durkheim’s theory of social solidarity had relevance to the ogoh-ogoh parade. In social action and solidarity, religious adherents, specifically Christians and Hindus, synergized and supported each other.
THE METAETHICAL IMPLICATIONS OF GOD'S ONTOLOGICAL STATUS IN TANTRIC TEACHINGS: A PHILOSOPHICAL STUDY OF CALON ARANG MANUSCRIPTS
Authors: Fattah Galuh Nur , Dewantri Puja Alviana , Tangrestu Venessya , Laras Valentin Gagah
Published: July 2024

This study aims to investigate the ontological status of God in Calon Arang Manuscripts and interpret it metaethically. Calon Arang, as an original Tantric literary work from the Nusantara's ancestors, is an interesting subject to examine in terms of its ontological view of God and the ethical implications that arise from it. Tantrism essentially conceptualizes God dualistically, depicting God in conflicting forms or elements, which are considered the cosmic basis of the world. This study highlights such dualistic tendencies and identifies potentially significant metaethical implications. An in-depth analysis is conducted utilizing a metaethical approach, specifically the school of natural determinism. This school believes that the moral laws that apply in human reality are in accordance with natural laws, so humans cannot determine objective morality with certainty. The ethical implications of God's ontological status in Tantric teachings are understood as a result of this natural determinism. This research places God's ontological status as the material object and uses natural determinism as the formal framework. Research methods include description, holistics, deduction-induction, and heuristics. With this approach, this research seeks to detail and unravel the complexity of the ontological view of God in the Calon Arang Manuscripts, while exploring the ethical implications that can bring a deeper understanding of this Tantric text.
تأثير تمرينات خاصة بالقوة المميزة بالسرعة والمناولة بالجــــــــزء الداخلي الامامي للقدم لتطوير دقة تهديف الكرات الثابته لدى لاعبي كرة القـدم الناشئين
Authors: احمد قادر هيوا
Published: July 2024

الخلاصة
     كرة القدم من الألعاب التي اعتمدت بشكل ملحوظ على تنوع المهارات المستخدمة اثناء شوطي المباراة فضلا عن حاجة اللاعبين كافراد وكمجموعة وبشكل دائم الى دقة تنفيذ هذه المهارات , مهارة تهديف الكرات الثابته تعد عاملا ذا اهمية قصوى لاجل تسجيل الاهداف وتحقيق الفوز في المباريات وهذا ما دفع الباحث الى دراسة استخدام تمرينات خاصة بالقوة المميزة بالسرعة و المناولة بالجزء الداخلي الامامي للقدم للتعرف على تاثيرها على دقة تسجيل الاهداف من الكرات الثابتة لدى لاعبي كرة القدم الناشئين وهنا تكمن أهمية البحث , تتمثل عينة البحث بلاعبي اكاديمية جلولاء الرياضية بكرة القدم لفئة الناشئين المعد للمشاركة في بطولة المحافظة للموسم 2023-2024 والبالغ عددهم (24) لاعبا , تم ابعاد (4) لاعبين عن التجربة لالتزامهم بالامتحانات الوزارية للمرحلة المتوسطة الدور الثاني , قام الباحث بترتيب اللاعبين تنازليا حسب نتائج اختبار مهاري من ثم تم تقسيمهم الى مجموعتين بطريقة المزاوجة بـ (10) لاعبين لكل مجموعة , وعن طريق القرعة تم تحديد المجموعة التجريبية والمجموعة الضابطة , استنتج الباحث ان التدريب على تمرينات خاصة بالقوة المميزة بالسرعة لعضلات الساقين وتمرينات المناولة بالجزء الداخلي الامامي للقدم ادت الى تطور في دقة تهديف الكرات الثابتة لدى افراد المجموعة التجريبية, وخرج الباحث بمقترحات خاصه بموضوع البحث.
Notes about folk edition on social networks
Authors: Conti Tamires Cristina Bonani , Almeida Terezinha Ferreira de
Published: July 2024

In this paper, we aim to reflect about the practice that has become a theme of an Instagram page: the rewriting of journalistic news, so that the headline appears erased with red pen, adapting it paradigmatically to the ideological position of its folk editor. Thus, for such, we based ourselves on Almeida's reflections (2021), being used the theoretical-methodological contribution of the French-oriented Discourse Analysis, more specifically of Maingueneau (2008), in an integrative proposal with Folk Linguistics, according to Paveau (2008). Our main results indicated that such folk intervention goes beyond the linguistic field, acting also as a folk judicial intervention.
The effect of a proposed unit in science based on PISA standards in developing life problem-solving skills among Prep school students
Authors: Alkest Naglaa Fauzy Esmaeil , Taha Mahmoud Ebrahim , Ghalwash Mohamed Mostafa
Published: July 2024

The current study aimed to identify life problem-solving skills that could be cultivated among middle school students, and to develop these skills through the implementation of a proposed unit within the science curriculum, aligning with the standards set forth by the Program for International Student Assessment (PISA). The study sample comprised 49 male and female students in the second preparatory grade at Batita Preparatory Mixed School in Kafr El-Sheikh. Tools employed included a life problem-solving skills test. The researcher utilized both descriptive analytical and experimental approaches, employing a quasi-experimental design. The findings of the study yielded a list of four key life problem-solving skills: exploration and understanding, representation and formulation, planning and implementation, and observation and reflection. Additionally, a statistically significant difference was observed between the average scores in the pre- and post-measurements of the research tool, with higher scores favoring the post-measurement. The study recommends the necessity of enhancing science curricula during the preparatory stage, aligning with the standards outlined by the International Program for Assessment (PISA), and emphasizing the development of requisite knowledge, skills, competencies, and attitudes among preparatory stage students.
Primernost ostankov mlete kave za proizvodnjo peletov
Authors: Gornik Bučar Dominika , Prislan Peter , Verhovšek Dejan , Gospodarič Bojan
Published: July 2024

Za doseganje cilja evropske energetsko-podnebne politike, da do leta 2050 dosežemo podnebno nevtralnost s prehodom na obnovljive vire energije, je potrebno aktivirati različne razpoložljive obnovljive vire, vključno z biološkimi ostanki oz. odpadki. Eden od takih bioloških odpadkov, ki nastaja v velikih količinah in se večinoma nepredelan odlaga v okolje, so ostanki mlete kave. Ker ostanke mlete kave sestavljajo celuloza, hemiceluloza, lignin in proteini, predstavljajo velik potencial tudi kot biogorivo, ki lahko delno nadomesti lesno biomaso pri proizvodnji peletov. V raziskavi smo v laboratorijskih pogojih izdelali pelete iz ostankov mlete kave, ki smo jim dodali različne deleže (0 %, 25 %, 50 %, 75 %) žagovine. Izdelanim peletom smo določili lastnosti in jih glede na izmerjene vrednosti razvrstili v kakovostne razrede po standardu SIST EN ISO 17225-6:2021. Ugotovili smo, da imajo peleti z večjim deležem ostankov mlete kave višjo kurilno vrednost, večjo vsebnost pepela ter nižjo mehansko obstojnost. Peleti, izdelani iz ostankov mlete kave in dodatkom žagovine (50 % ali več), izkazujejo obetavne lastnosti kot vhodna surovina za proizvodnjo peletov.
BLOCKCHAIN TECHNOLOGY UNDER THE LENS OF SOCIAL INNOVATION: ILLUSTRATING DIMENSIONS AND ELEMENTS IN A SOCIAL FINTECH
Authors: Loiola Ricardo Alan Kardec , Lazáro José Carlos , Neutzling Daiane Mulling , Leocadio Aurio Lucio
Published: July 2024

Objective: This article is intended to demonstrate how the use of Blockchain by a Social Fintech can be viewed under the lens of the Social Innovation construct and its elements (dimensions).
 
Theoretical Framework: The configuration of the elements (dimensions) was based on studies by Tardif and Harrisson (2005), Cloutier (2003) and André and Abreu (2005), according to the model of Souza, Lessa and Lazaro (2019).
 
Method: The study was descriptive and exploratory. The case study method was applied with content analysis. The initial inductive analyzes made three dimensions for social innovation emerge more clearly: the Character component, Social Innovativeness and Transformation.
 
Results and Discussion: We came to the conclusion that access to credit using Blockchain technology to fulfill a social demand values territorial specificities through the organization and mobilization of excluded groups and territories, and helps in altering behavior, attitudes or perceptions.
 
Research Implications: The role of this research for the area of study shows the dimensions of social innovation as a tool for analyzing a social enterprise. Further investigation with more depth in other settings and evaluating the results is essential for this field. New Social Fintechs are continually emerging. Within this environment, economic models are being transformed as they seek a way to break down barriers in the most adversarial models of society by using blockchain technology.
 
Originality/Value: The relevance of this research is related to the role of improving the concept and practices of social innovation and the development of initiatives geared towards social economic inclusion.