bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Student Graduation with the Neural Network Method Based on Particle Swarm Optimization
Authors: Nurdin Hafis , Sartini Sartini , Sumarna Sumarna , Maulana Yana Iqbal , Riyanto Verry
Published: October 2023

In private universities in Indonesia, student graduation is something that is worth paying attention to, because it will be an aspect of the success of the university. Universities certainly have data on students who graduated, where student graduation data is very important to be taken into consideration by private universities, however with a lot of data it will make it difficult for private universities to find information from this data. Other researchers have previously carried out student graduation data with the same data by examining student graduation data using other methods. So we need a data mining algorithm that has never been tested on student graduation data. The method used is the neural network method with an optimization method, namely the particle swarm optimization method, to test the data, which will later produce information that is very useful for universities. After testing the student graduation data and getting accuracy results using the neural network method of 84.55% and after being optimized using the particle swarm optimization method, the accuracy results were optimal with a value of 86.94%. These results can be used by private universities to predict that students will graduate on time before they take their final semester so that the student graduation rate will be high.
Digital Transformation in University: Enterprise Architecture and Blockchain Technology
Authors: Iswahyudi Iswahyudi , Hindarto Djarot , Indrajit R. Eko
Published: October 2023

Implementing digital transformation in higher education is now required for effective adaptation to rapid technological advances. Utilizing Enterprise Architecture (EA) with blockchain technology is a recommended strategic approach for implementing digital transformation. The college first ascertains the University's digital transformation requirements and goals, which include data management, security, operational efficiency, and transparency. In addition, formulating a strategic plan to determine the optimal integration of blockchain technology within the college's architectural framework, including the judicious selection of the most suitable blockchain platform, is essential. In addition, developing a company's architecture must prioritize seamless integration with existing systems while upholding data security and consistency principles. Consideration should be given to the significance of training and awareness building among faculty and students. In addition, the implementation process must be conducted in phases with consistent monitoring and evaluation. The success of this project is contingent upon the formation of partnerships and collaborations with blockchain technology companies, as well as a thorough understanding of the applicable regulatory framework. By adopting this methodology, the University can increase operational efficiency, bolster data security measures, and improve the educational experience. This research aims to increase efficiency, data security, transparency, and educational innovation in universities using Blockchain Technology and University Enterprise Architecture.
Blockchain-Based Academic Identity and Transcript Management in University Enterprise Architecture
Authors: Hindarto Djarot
Published: October 2023

The present research examines the implementation of Blockchain-based Identity and Academic Transcript Management in a university's enterprise architecture. This research is motivated by the increasing demand for secure, transparent, and efficient student identity management and the need to store easily verifiable academic transcripts. Blockchain technology has been spotlighted because it provides security and data integrity solutions. This research aims to determine if integrating Blockchain into the University's Enterprise Architecture can improve the management of student identities and academic transcripts by reducing the risk of forgery and facilitating more dependable access for interested parties. Increased security and efficiency in managing student data are the practical implications of this research, which can help universities reduce the risk of data loss and increase stakeholder trust. This research method includes surveying various universities that have adopted Blockchain technology in their academic identity and transcript management. In addition, we will assess its technical implementation, evaluate its effect on efficiency, and conduct interviews with university personnel involved in the implementation process. This study's anticipated outcome is providing universities planning to adopt Blockchain technology for Enterprise Architecture with actionable guidance. This research will identify the benefits, challenges, and best practices of integrating Blockchain in academic identity and transcript management and lay the groundwork for further improvement of educational services in university settings.
Enterprise Architecture Design for the Transformation of Online Financial Services
Authors: Wedha Bayu Yas , Vasandani Michael Sagar , Wedha Alessandro Enriqco Putra Bayu
Published: October 2023

In the ever-expanding digital era, online financial services have emerged as a significant component of the global financial ecosystem. Digital transformation has altered the operations and consumer interactions of financial services companies. By implementing Enterprise Architecture design, financial services companies can adapt, flourish, and compete in an increasingly competitive environment. This article examines the essential function of Enterprise Architecture in the evolution of online financial services. We explore how Enterprise Architecture provides a strategic framework for driving change and innovation in financial organizations. We examine the primary elements of an Enterprise Architecture, such as the business model, technology infrastructure, and data. Then, we investigate how Enterprise Architecture improves operational efficiency and decreases risk in digital financial services. In addition, the significance of security and conformance in Enterprise Architecture for online financial services is examined. Enterprise Architecture is crucial in integrating security solutions and ensuring regulatory compliance in light of rising cybersecurity threats, strict regulatory compliance, and consumer demands for data privacy. We discuss how Enterprise Architecture facilitates improved consumer experiences in online financial services. By designing solutions with the consumer in mind, businesses can meet customer expectations, increase customer retention, and build a sustainable market share. Enterprise Architecture has become an indispensable instrument for successfully transforming online financial services. Through strategic planning, technology integration, data management, and a focus on security and customer experience, financial institutions can meet the challenges and seize the opportunities presented by the digital era.
Three Pass Protocol for Key Security Using Affine Cipher Algortima and Exclusive-or (Xor) Combination
Authors: Harahap Muhammad Ikhwan , Suherman Suherman , Sembiring Rahmat W
Published: October 2023

Information is a very important concern in today's technological era, especially in terms of security through the exchange of information that is so fast that people can easily get various kinds of information. Information obtained easily through recording or openly disseminating data, XOR Cipher is an algorithm used to secure messages and texts but has weaknesses due to simple computation, therefore to strengthen security in XOR Cipher communication protocols can be added to secure key exchange on XOR Ciphers. Affine Cipher can be combined with Exclusive-OR (XOR) for text message security. Through the Affine Cipher algorithm with Key can change the unknown Plaintext, so that the Plaintext is kept secret. The Exclusive-OR (XOR) combination by changing each Character in each Plaintext according to the ASCII Code table can shorten the Key encoding process, so that Plaintext remains safe to send. The Affine Cipher Algorithm and the Exclusive-OR (XOR) Combination for Plaintext security levels are better because the Plaintext encryption and decryption processes are carried out twice with different cryptographic algorithms.
FORMULATION AND STABILITY TEST OF CREAM FROM JUICE OF BELIMBING WULUH (AVERRHOA BILIMBI l.)
Authors: Evma Rahayu Feronika , Silvyana Annysa Ellycornia , Warti Lia , Asih Dentri
Published: October 2023

Research on cream formulations using starfruit (Averrhoa bilimbi L.)  juice has been carried out to determine the effect of sodium lauryl sulfate on the physical stability of cream from starfruit juice. Carambola wealth as an active substance is made in cream with varying concentrations of sodium lauryl sulfate of 1%, 1.5%, 2%, and 2.5%. The evaluation was carried out in the form of organoleptic tests, homogeneity, cream type, pH, viscosity, centrifugation, and freeze-thaw. Data analysis was carried out using statistical tests using ANOVA which has a 95% confidence level (α = 0.05), the test is continued with the Tukey HSD test, and the analysis results show significant differences in each formula. The research results concluded that the higher the concentration of sodium lauryl sulfate as an emulsifying agent, the physical stability of the viscosity of the cream from starfruit juice increased.
Pencegahan Infeksi HIV Pada Wanita Subur
Authors: Dewiastuti Marlina
Published: October 2023

Prevalensi   infeksi  Human Immunodeficiency Virus (HIV) di dunia meningkat 0.7% , walaupun peningkatan tidak sebesar pada tahun  1990-an diperkirakan saat ini 38 juta penduduk dunia terinfeksi HIV dan sebanyak 17.6 juta wanita usia subur terinfeksi HIV. Kasus infeksi HIV di Indonesia mengalami peningkatan, data tahun 2019 diperikirakan 50.282 terinfeksi HIV.  Jawa Barat merupakan kota tertinggi ketiga populasi terinfeksi HIV. Indramayu salah satu kota di Jawa Barat mengalami peningkatan jumlah kasus infeksi HIV, berdasarkan data belum tercapai target sasaran bidang Kesehatan, yang mana target kasus baru HIV <0.05%. Meningkatnya kasus HIV meningkatkan  masalah kesehatan. Infeksi HIV merupakan penyebab kematian   pada wanita usia subur. Wanita usia subur merupakan jembatan epidemi infeksi HIV dari risiko rendah menjadi risiko tinggi. Selain itu wanita usia subur yang terinfeksi HIV akan berisiko menularkan ke anaknya kelak.  Berbagai macam upaya sudah dilakukan dalam mencegah peningkatan infeksi HIV, baik pencegahan primer dan pencegahan sekunder. Upaya pencegahan  dilakukan secara berkala dan mampu menjangkau semua lapisan masyarakat.  Pemberian informasi mengenai HIV secara komprehensif , pencegahan dan transmisi,  mencegah penularan ke anak, dan banyaknya miskonsepsi tentang HIV.  Pengabdian kepada masyarakat ini bertujuan memberikan informasi yang komprehensif mengenai pencegahan infeksi HIV terutama pada wanita usia subur sebagai populasi kunci. Hasil dari pengabdian kepada masyarakat didapatkan pengetahuan yang rendah sebelum dilakukan edukasi dan setelah dilakukan terdapat peningkatan kemampuan. Edukasi berkala dapat meningkatkan pengetahuan dan diharapkan dapat menurunkan kejadian HIV.
Edukasi Pencegahan Penularan Scabies Dalam Rangka Peningkatan Ketahanan Kesehatan dan Pendidikan di SMP IT Insan Mandiri Boarding School
Authors: Isniani Ramadhani  , Hadiwiardjo Yanti Harjono , Chairani Aulia , Agustini Diana , Dwicahyo Andhanputra Nur Agung , Dyah Pitaloka Pradipta Ayu
Published: October 2023

Kesehatan adalah keadaan sehat jasmani, rohani, rohani, dan sosial yang memungkinkan setiap orang hidup produktif secara sosial dan ekonomi. Sedangkan ketahanan nasional adalah kondisi kehidupan bangsa yang harus diwujudkan dan dibina sejak dini, berkesinambungan, dan sinergis mulai dari diri sendiri, keluarga, lingkungan, wilayah, dan bangsa yang mengandung kemampuan untuk mengembangkan kekuatan nasional. Proses penanaman nilai ketahanan perlu dilakukan dengan komunikasi dua arah antara pendidik dan peserta didik. Scabies merupakan infeksi kulit yang paling banyak terjadi di pesantren. Meski dianggap sebagai penyakit tropis yang terlupakan karena tidak menyebabkan kematian, namun jika tidak ditangani secara serius dapat menyebabkan penurunan ketahanan kesehatan dan ketahanan pendidikan pada daerah tertular dan penderitanya. Gatal parah di malam hari menyebabkan kualitas tidur dan konsentrasi di pagi hari terganggu. Oleh karena itu, santri Pesantren SMPIT Insan Mandiri perlu dibekali pengetahuan untuk mencegah penyebaran infeksi Scabies. Menggunakan metode konseling dengan evaluasi pre-test dan post-test. Penyuluhan terbukti berpengaruh terhadap peningkatan pengetahuan sebagian besar peserta terkait skabies dan ketahanan kesehatan dengan bukti 57 peserta (95%) mengalami peningkatan skor post test.
Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach.
Authors: Ueno T , Tremblay J , Kuneš J , Zicha J , Dobešová Z , Pausová Z , Deng AY , Sun Y , Jacob HJ , Hamet P
Published: October 2023

A total genome scan and pharmacogenetic study were designed to search for genetic determinants of blood pressure (BP) as well as heart and kidney weights. Genome scanning was carried out in 266 F2 intercrosses from Prague hypertensive hypertriglyceridemic rats for phenotypes of organ weights, baseline BP, BP after blockade of the renin-angiotensin system (RAS) by losartan, of the sympathetic nervous system (SNS) by pentolinium, and of the nitric oxide (NO) synthase by NG-nitro-L-arginine methyl ester. Pharmacogenetic analysis showed that, in males, BP was controlled by two loci on chromosomes 1 and 5 (Chr1, Chr5) through the SNS, and these loci showed a positive contribution for relative kidney weight (KW/BW). On the other hand, baseline BP in females was controlled by two loci on Chr3 and Chr7. The effect of these loci was not mediated by the RAS, SNS or NO system. These loci did not show any effect for KW/BW. Negatively-linked loci for KW/BW and relative heart weight (HW/BW) were identified on Chr2 in both genders. Another negatively-linked locus for KW/BW, located on Chr8 in males, affected BP through the SNS. This locus on Chr8 overlapped with a previously-reported modifier locus for polycystic kidney disease (PKD). In conclusion, this pharmacogenetic study determined two loci for BP and relative organ mass implicating sympathetic overactivity. Concordance of the identified locus for KW/BW and BP through the SNS on Chr8 with the PKD locus revealed the importance of this region for renal complications in various diseases.
Pathophysiological and clinical importance of insulin-like growth factor-I with respect to bone metabolism.
Authors: Žofková I
Published: October 2023

The modern concept of causality of diseases emphasizes the study of natural defense functions of the organism and possibilities of influencing them, which will lead to effective prevention of these diseases. A great deal of information has been obtained on the system growth hormone (GH)/insulin-like growth factor (IGF)-I, which is of quite fundamental importance for the integrity of the organism. A dysbalance of the system may be the cause of diseases of the neonatal period, as well as diseases associated with aging. In old age, the synthesis of the crucial peptide system, IGF-I, declines as well as the sensitivity of tissues to this hormone. At the same time the changes in the expression of IGF-binding proteins (IGFBP) occur. Systemic growth factors are present in measurable concentrations in the circulation, they are, however, taken up or synthesized by some tissues, where they act as local cellular regulators. IGF-I is produced by many tissues, including bones under the control of estrogens, growth hormone and the parathyroid hormone. A decline of bone IGF-I in the cortical portion of bones is one of the many mechanisms leading to the development of involutional osteoporosis. Correlation studies, which have provided evidence of a relationship between the IGF system and the building of peak bone mass and its subsequent loss contributed to the understanding of the pathogenesis of this disease. It may be foreseen that the results of intervention studies focused on the effects of the recombinant IGF-I will also influence therapeutic and preventive approaches. Modern antiresorption pharmacotherapy stabilizes or enhances bone density and reduces the risk of fractures. The addition of effective anabolics might increase the effectiveness of treatment by shifting the remodeling equilibrium in favor of formative processes. Because both recombinant GH and IGF-I have certain therapeutic limitations, it is considered to utilize substances which either stimulate endogenous IGF-I production directly in the bone or modulate synthesis and distribution of binding proteins for the peptide. Further new findings related to physiology and pathophysiology of this peptide will contribute to designing new strategies in the prevention of osteoporosis and other serious diseases of old age, such as diabetes, neoplasias or cardiovascular diseases.
Several functions of immune cells changed in mice with oxidative stress caused by endotoxin.
Authors: Víctor VM , De la Fuente M
Published: October 2023

We have studied natural killer (NK) activity, lymphoproliferative response, the release of several cytokines (IL-2, TNFa and IL-1b) and the ROS production in peritoneal leukocytes obtained 0, 2, 4, 12 and 24 h after lipopolysaccharide (LPS) injection. Lethal septic shock (100 % mortality occurred at 30 h after LPS administration) was caused in female BALB/c mice by intraperitoneal injection of 100 mg/kg of E. coli LPS. Cytotoxicity and lymphoproliferation assay were preformed together with the measurement of IL-1b, IL-2 and TNFa production, and quantification of ROS. Natural killer activity, spontaneous lymphoproliferative response, IL-2, TNFa, IL-b release and ROS production were increased after LPS injection. In conclusions, ROS and proinflammatory mediators produced by immune cells in response to LPS are involved in the oxidative stress of endotoxic shock. This oxidative state alters some functional characteristics of leukocytes (proliferation and NK activity).
Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension.
Authors: Pravenec M , Landa V , Zídek V , Musilová A , Kazdová L , Qi N , Wang J , St.Lezin E , Kurtz TW
Published: October 2023

Spontaneously hypertensive rats (SHR/NIH strain) harbor a deletion variant in the Cd36 fatty acid transporter and display defective fatty acid metabolism, insulin resistance and hypertension. Transgenic rescue of Cd36 in SHR ameliorates insulin resistance and improves dyslipidemia. However, the role of Cd36 in blood pressure regulation remains controversial due to inconsistent blood pressure effects that were observed with transgenic expression of Cd36 on the SHR background. In the current studies, we developed two new SHR transgenic lines, which express wild type Cd36 under the control of the universal Ef-1 promoter, and examined the effects of transgenic expression of wild type Cd36 on selected metabolic and cardiovascular phenotypes. Transgenic expression of Cd36 in the new lines was associated with significantly decreased serum fatty acids, amelioration of insulin resistance and glucose intolerance but failed to induce any consistent changes in blood pressure as measured by radiotelemetry. The current findings confirm the genetic association of defective Cd36 with disordered insulin action and fatty acid metabolism in the SHR/NIH strain and suggest that Cd36 is linked to other gene(s) on rat chromosome 4 that regulate blood pressure.
Polarographic evaluation of mitochondrial enzymes activity in isolated mitochondria and in permeabilized human muscle cells with inherited mitochondrial defects.
Authors: Wenchich L , Drahota Z , Honzík T , Hansíková H , Tesařová M , Zeman J , Houštěk J
Published: October 2023

Inherited disturbances of the mitochondrial energy generating system represent a heterogeneous group of disorders associated with a broad spectrum of metabolic abnormalities and clinical symptoms. We used the polarographic and spectrophotometric method for detection of mitochondrial disorders, because these two techniques provide a different insight into mitochondrial function. In six patients suspected of mitochondrial disease we found defects of complex I (two patients), complex III (one patient), complex IV (two patients) and a combination of defect of complex III and IV (one patient). Citrate synthase activity, used as the reference enzyme, was not changed. A comparison of the two methods showed several differences in evaluation of mitochondrial enzymes activity due to the fact that both methods used different conditions for enzyme activity measurements. In contrast to oxygen consumption measurements, where the function of the whole-integrated respiratory chain is characterized, spectrophotometric measurements characterize activities of isolated complexes in disintegrated membranes. However, it may be concluded from our experiments that both methods provide useful and complementary data about mitochondrial energetic functions. Whereas spectrophotometric data are suitable for evaluation of maximal enzyme activities of mitochondrial enzyme complexes, polarographic data provide better information about enzyme activities in cells with mitochondrial defects under in situ conditions.
Estrogen effect on some enzymes of female rats after downhill running.
Authors: Sotiriadou S , Kyparos A , Mougios V , Trontzos Ch , Sidiras G , Matziari Ch
Published: October 2023

The study investigates the effect of administered estrogen on plasma creatine kinase (CK) and lactate dehydrogenase (LD) levels in female ovariectomized rats after downhill running. Rats ovariectomized before sexual maturity were subcutaneously implanted with pellets containing 17β-estradiol or placebo. Three weeks later they were subjected to a 90-min intermittent downhill running protocol. Blood samples were obtained from the jugular vein immediately after and 72 h after exercise for determination of plasma CK, LD and 17β-estradiol levels. A two-way analysis of variance was used for data evaluation. Plasma CK and LD levels were significantly lower (p<0.05) in the estrogen-supplemented, ovariectomized animals which suggests that less muscle damage occurred compared to the controls immediately and 72 h after exercise. Estrogens may have a protective effect on muscle tissue possibly due to their antioxidant and membrane stabilizing properties.
Effect of quercetin on daunorubicin-induced heart mitochondria changes in rats.
Authors: Guzy J , Kušnír J , Mareková M , Chavková Z , Dubayová K , Mojžišová G , Mirossay L , Mojžiš J
Published: October 2023

Cancer therapy with daunorubicin is limited by its cardiotoxicity. It has been suggested that daunorubicin-induced free radical generation can be involved. The precise molecular mechanism of daunorubicin-induced cardiotoxicity is still not well understood but it is believed that mitochondria play an important role in this process. It has been reported that flavonoids with antioxidant properties may prevent anthracycline-induced cardiotoxicity. In this work, we investigated the effects of daunorubicin and quercetin on mitochondrial enzyme activities such as ATPase, glutathione peroxidase (GPx) and glutathione reductase (GR). Moreover, we also studied the changes of outer mitochondrial membrane using synchronous fluorescence spectra. The actitivity of ATPase and GR were significantly increased after daunorubicin application. Pretreatment with quercetin significantly alleviated this increase. On the other hand, GPx activity was significantly decreased and quercetin prevented this decrease. Treatment with quercetin alone had no significant effect on the enzyme activity studied. Quercetin also completely prevented daunorubicin-induced changes in fluorescence of the outer mitochondrial membrane. In conclusion, our data indicate that quercetin may be useful in mitigating daunorubicin-induced cardiotoxicity.
N-methyl-D-aspartate prevented memory deficits induced by MK-801 in mice.
Authors: Hliňák Z , Krejčí I
Published: October 2023

An interaction between N-methyl-D-aspartate (NMDA) and MK-801 was examined in mice using a modified elevated plus-maze paradigm that allows assessment of the adaptive form of spatial memory. NMDA administered (s.c.) immediately after the acquisition session protected the animals against the amnesia induced by MK-801 given shortly before the retention session. Behavioral performance, expressed as the transfer latency, and therefore spatial memory potency of NMDA plus MK-801 treated animals was comparable with that of both NMDA-treated animals and the controls.
Farrerol Alleviates Hypoxic-Ischemic Encephalopathy by Inhibiting Ferroptosis in Neonatal Rats via the Nrf2 Pathway
Authors: Li Y , Wang T , Sun P , Zhu W , Chen Y , Chen M , Yang X , Du X , Zhao Y
Published: October 2023

Farrerol (FA) is a traditional Chinese herbal medicine known for its anti-inflammatory and anti-oxidative properties in various diseases. Ferroptosis is an iron-dependent oxidative stress-induced cell death. It is characterized by lipid peroxidation and glutathione depletion and is involved in neuronal injury. However, the role of FA in inhibiting ferroptosis in hypoxic-ischemic encephalopathy (HIE) and its underlying mechanisms are not yet completely elucidated. This study aimed to investigate whether FA could mediate ferroptosis and explore its function and molecular mechanism in HIE. A neonatal rat model of HIE was used, and rats were treated with FA, ML385 (a specific inhibitor of nuclear factor erythroid 2-related factor 2 [Nrf2]), or a combination of both. Neurological deficits, infarction volume, brain water content, pathological changes, and iron ion accumulation in the brain tissues were measured using the Zea-Longa scoring system and triphenyl tetrazolium chloride (TTC), hematoxylin-eosin (HE), and Perls’ staining. The expression levels of GSH-Px, MDA, SOD, and ROS in brain tissues were also evaluated. Western blot analysis was performed to analyze the expression of the Nrf2 pathway and ferroptosis-related proteins. The results showed that FA administration significantly reduced neuronal damage, infarct volume, cerebral edema, and iron ion accumulation and inhibited MDA and ROS levels while promoting GSH-Px and SOD levels. FA also increased the expression levels of glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), Nrf2, and HO-1. Moreover, the combination of ML385 and FA in HIE abolished the FA protective effects. Therefore, the study concludes that FA exerts a neuroprotective effect after HIE by inhibiting oxidative stress and ferroptosis via the Nrf2 signaling pathway.
Effect of Body Weight and Obesity on Esophageal Function
Authors: Yang Y , Lin J-R , Li Y-Q , Wei Y-S , Duan Z-J
Published: October 2023

The incidence of obesity in the population is gradually increasing. Obesity can cause a variety of complications in the digestive system such as gastroesophageal reflux disease, and impacts the integrity of the esophageal mucosal barrier and esophageal motility. However, not many studies have focused on the effect of varying degrees of obesity on the esophagus. A total of 611 participants were included in this study. We divided them into three groups according to their body mass index (BMI): the normal weight group, the overweight group, and the obesity group. We performed a retrospective comparison between groups based on indicators from high resolution esophageal manometry (HREM) and 24-hour pH impedance monitoring, and did a correlation analysis on multiple indicators such as esophageal mucosal barrier, esophageal motility, and acid reflux. The mean nocturnal baseline impedance (MNBI) in the overweight and obesity groups was lower than that in the normal group. The MNBI of the subjects in Z5–Z6 channels in the overweight group was significantly lower than that in the normal group. With respect to Z3–Z6 channels, MNBI values in the obesity group were significantly lower than those in the normal group. 'The acid exposure time (AET), the DeMeester scores (DMS) and 24-hour total reflux episodes was significantly higher in the obesity group than those in the normal and overweight groups. The upper esophageal sphincter (UES) residual pressure, and intrabolus pressure (IBP) in the overweight and obesity groups were significantly higher than those in the normal group. In addition, lower esophageal sphincter (LES) resting pressure, and esophagogastric junction contractile integral (EGJ-CI) in the obesity group were significantly higher than those in the normal group. We found that increase in body weight affected the integrity of esophageal mucosa, and different degrees of increase associated with different degrees and different aspects of changes in esophageal motility.
ANALISIS PENGENDALIAN KUALITAS HASIL PRODUK CETAK KEMASAN DENGAN METODE SIX SIGMA PADA INDUSTRI PERCETAKAN
Authors: Vugun Nur Fauzi  , Sumarsono  , Sulung Rahmawan Wira Ghani  , Andhika Mayasari
Published: October 2023

Maintaining high quality is crucial for any company that produces goods. PT. Dharma Anugerah Indah specializes in printing and packaging, but customers have been complaining about the quality of their products in 2022. Specifically, there were many defects in the packaging, particularly problems with the color. These defects have caused a decrease in customer trust and could harm the company's reputation. This study aims to identify the problems causing the defects that are triggering customer complaints. To analyze the defects, we used the Six Sigma method with the DMAIC cycle and the FMEA method. In the define phase, we found that the most significant problems were related to color, bad printing, and bad glueing. These issues were mainly caused by operator negligence, frequent machine trouble, poor materials, and inadequate environmental conditions. However, our Six Sigma calculations show that the Sigma levels were good, ranging from 4.2 to 4.24. We also used the FMEA method to prioritize the failure modes and determine proposed improvements. Based on the proposed improvements, we recommend scheduling work training, monitoring employee performance, maintaining production machines, and increasing awareness of the work environment to improve production quality.
ANALISIS PERAMALAN PERMINTAAN KARTON BOX UD BERKAH JAYA OFFSET MENGGUNAKAN METODE TIME SERIES
Authors: Yoga Satya Andriawan  , Nur Muflihah
Published: October 2023

UD Berkah Jaya Offset is one of the manufacturing companies operating in the field of cardboard box production. The company offers a variety of cardboard box products in various sizes, including sizes D1, D2, D3, trepes, and roll. In the production of cardboard boxes, particularly size D1, issues such as overstock and even stock shortages have been frequently encountered during the period from January 2022 to December 2023. This is due to the ineffective demand forecasting to anticipate these possibilities. This study aims to forecast the demand for size D1 cardboard boxes for the upcoming months using the best forecasting method. The methods employed are decomposition method, Winter's exponential smoothing, and Holt's exponential smoothing. This research compares the three methods based on the smallest Mean Absolute Percentage Error (MAPE) value. The results of the study reveal that the decomposition method is the most effective, with a MAPE value of 19,  MAD value of 28000, and MSD value of 1247419480, indicating a low level of forecasting error compared to the others.
Gereja dengan Model Hibrida: Sebuah Pendekatan Eklesiologi di Era Pasca Pandemi COVID-19
Authors: Nole Otniel Aurelius
Published: October 2023

The Church can contemplate and act upon the implementation of its activities in the post-COVID-19 pandemic era. Generally, the Church has traditionally conducted its activities in a face-to-face manner, but the increasing modernization of society has led to the adoption of indirect methods as well. In this research, these two approaches are not seen as contradictory but are viewed from a different perspective, presenting a model for the Church, namely the hybrid model. The aim of this research is to demonstrate that the hybrid Church model is an intriguing and beneficial ecclesiological approach for the enhancement of a healthy and vibrant Church in contemporary times. This study employs a literature review to present an argument based on valid references, and the author also conducts field research, including observations and interviews, as data collection techniques. The author finds that the hybrid model can serve as a solution to assist churches in carrying out religious practices.

Abstrak Indonesia 

Gereja dapat berpikir dan bertindak tentang pelaksanaan kegiatannya di era pasca pandemi COVID-19. Secara umum, gereja melakukan kegiatan secara langsung, tetapi perkembangan zaman yang kian modern membuat gereja juga memberlakukan kegiatan secara tidak langsung. Dalam penelitian ini, kedua hal itu tidak dipertentangkan, melainkan diambil sudut pandang lain dengan menampilkan suatu model bagi gereja, yaitu hibrida. Tujuan penelitian ini menunjukkan bahwa gereja bermodel hibrida adalah pendekatan eklesiologi yang menarik dan bermanfaat tentang peningkatan gereja yang sehat dan segar di zaman kontemporer. Penelitian ini menggunakan studi kepustakaan dalam memunculkan suatu argumen dari referensi valid, serta penulis juga melakukan studi lapangan berupa observasi dan wawancara sebagai teknik pengumpulan datanya. Penulis menemukan bahwa model hibrida dapat menjadi jawaban untuk membantu gereja-gereja melaksanakan praktik religius.
Strategi Penginjilan Paulus di Efesus Berdasarkan Kitab Kisah Para Rasul 19-20 dan Implementasinya Pada Masyarakat Majemuk Masa Kini
Authors: Baskoro Paulus Kunto , Yudhistira Elkana
Published: October 2023

Ephesus was one of the significant and pivotal cities within the Roman Empire. A characteristic of a major urban center is the diverse social fabric it encompasses. The Apostle Paul, chosen as God's anointed messenger, achieved remarkable success in converting souls within this city, even establishing a congregation in Ephesus. In the pages of Acts 19 and 20, one can glean insights into the strategies employed by Paul in spreading the gospel throughout Ephesus, resulting in the conversion of many individuals to believe in Jesus and the establishment of the Ephesus church. The methodology employed in this article adheres to qualitative descriptive principles. The objectives of this research are twofold: First, to thoroughly examine and elucidate the strategies employed by Paul during the establishment of the Ephesian church as documented in Acts 19 and 20. Second, to adapt and apply these strategies in contemporary times, with the goal of optimizing the fulfillment of Jesus Christ's Great Commission.

Abstrak Indonesia 

Efesus adalah salah satu kota besar dan penting pada zaman kekaisaran Romawi. Ciri khas sebuah kota besar adalah kemajemukan sosial yang ada di dalamnya. Rasul Paulus sebagai rasul yang diurapi Tuhan, telah berhasil memenangkan jiwa di kota ini bahkan membangun sidang jemaat di Efesus. Dalam kitab Kisah Para Rasul 19 dan 20, dapat dipelajari strategi yang Paulus lakukan dalam memberitakan Injil di kota Efesus, sehingga banyak orang yang dimenangkan percaya Yesus dan gereja Efesus berdiri. Metode yang dipakai dalam artikel ini adalah metode deskriptif kualitatif. Tujuan dari penelitian ini yaitu Pertama, mengkaji dan menemukan strategi yang dilakukan oleh Paulus dalam berdirinya jemaat Efesus dalam Kisah Para Rasul 19 dan 20. Kedua, mengimplementasikan dalam zaman modern untuk memaksimalkan pelaksanaan amanat agung Tuhan Yesus Kristus.
Exploring the Factors Involved in Tourists’ Decision-Making and Determinants of Length of Stay
Authors: Mihai Valentin C. , Dumitras Diana E. , Oroian Camelia , Chiciudean Gabriela O. , Arion Felix H. , Mureșan Iulia Cristina
Published: October 2023

This study aimed at identifying the factors influencing tourists’ decisions in choosing their vacation destinations as well as factors influencing their behavior. An online survey was applied to 861 Romanian tourists. The principal component analysis was run to reduce the dimensionality of the 23 items and used to determine the factors that influence tourists’ decision in choosing their destination, leading to a four-component solution. The results indicated that aspects related to destination image, destination unique characteristics and the accommodation facilities are more important for women than for the men. Regarding the travel organization factor, there was no statistically significant difference between the two groups. Families and older tourists with high incomes are positively linked to the length of stay. These insights on the factors influencing tourists’ decision-making process are of the utmost importance for managers and overall tourism service providers in the design of marketing and management strategies in accordance to tourists’ expectations and needs.
Satisfaction with Internal Communication and Hospitality Employees’ Turnover Intention: Exploring the Mediating Role of Organizational Support and Job Satisfaction
Authors: Duarte Ana Patrícia , Silva Vítor Hugo
Published: October 2023

Managing employee turnover is a key function in human resource management (HRM) that has become especially relevant given current staff shortages. The travel and tourism industry has been strongly affected, with many organizations having difficulty attracting and retaining workers. Portugal, as a prominent player in tourism, is no exception, and the workforce shortage crisis has been discussed in various forums and has attracted media attention. The present study examined hotel employees’ turnover intention and its relationship with their job satisfaction and positive perceptions of internal communication and organizational support. The proposed theoretical model included that internal communication contributes to the quality of employee–organization relationships by increasing perceived organizational support and job satisfaction, which in turn serve as sequential mediators of hotel workers’ diminished intent to leave their employer. Multiple regression analyses were performed using data collected from 12 hotels (number = 370 workers). The results support the model as they confirm that a statistically significant negative relationship exists between employees’ satisfaction with internal communication and their turnover intention. These variables are both directly and indirectly connected through perceived organizational support and job satisfaction. Implications for HRM are discussed including the importance of refining internal organizational communication to strengthen employee–organization ties.
Exploring the Roles of Arbuscular Mycorrhizal Fungi in Plant–Iron Homeostasis
Authors: Rajapitamahuni Soundarya , Kang Bo Ram , Lee Tae Kwon
Published: October 2023

Arbuscular mycorrhizal fungi (AMF) form a vital symbiotic relationship with plants. Through their extensive hyphal networks, AMF extend the absorptive capacity of plant roots, thereby allowing plants to reach otherwise inaccessible micronutrient sources. Iron, a critical micronutrient involved in photosynthesis and other metabolic processes, often becomes inaccessible owing to its tendency to form insoluble complexes in soil. AMF symbiosis significantly ameliorates this challenge by enhancing iron uptake and homeostasis in plants, altering root architecture, and producing root exudates that improve iron solubility. Moreover, the interaction with diverse soil bacteria, particularly plant growth-promoting rhizobacteria, can potentiate the benefits of AMF symbiosis. Siderophores are low-molecular-weight chelators with iron-binding capacities produced by various microorganisms and plant roots. They play pivotal roles in regulating intracellular iron and have been identified in different mycorrhizal associations, including AMF. While molecular mechanisms behind AMF-mediated iron uptake have been partially explored, the intricate networks involving AMF, plants, siderophores, and other soil microbiota are largely unknown. This review focuses on the multifaceted roles of AMF in plant–iron homeostasis, interactions with soil bacteria, and the potential of siderophores in these processes, emphasizing the possibilities for harnessing these relationships for sustainable agriculture and enhancing plant productivity.
Grain Yield Potential of Intermediate Wheatgrass in Western Canada
Authors: LeHeiget Patrick M. , McGeough Emma J. , Biligetu Bill , Cattani Douglas J.
Published: October 2023

Intermediate wheatgrass (Thinopyrum intermedium; IWG) is a temperate perennial grass capable of performing in dual-purpose perennial grain cropping systems. It is valued for its ecosystem services and forage yield and quality that can be utilized in many livestock systems. Development for potential perennial grain yield has been the focus of breeding programs for more than two decades, and agronomic management is becoming important, as commercialization of the crop has occurred. This research focused on nitrogen management and intercropping on grain yield and yield components in western Canada. Treatments consisting of a non-fertilized control, an interseeded crop with IWG/Trifolium hybridum, and a fertilized treatment (50 kg N ha−1) were investigated at four locations. Drought conditions were experienced in some years, resulting in the loss of the interseeded crop at three locations. Fertilization with nitrogen increased grain yield in harvest years two and three and influenced yield components in at least one instance across locations. Third-year grain harvests were higher or equal to year one yield at the two locations harvested, with applied N increasing yield on average by 200 kg ha−1 in year three. Inflorescence density is an important yield component after the first production year. The potential for consistent grain yields across three reproductive years was demonstrated, enhancing the potential for sustained productivity.
Response of Shoot and Root Growth, Yield, and Chemical Composition to Nutrient Concentrations in Soybean Varieties Grown under Soilless and Controlled Environment Conditions
Authors: Abd Ghani Rosnani , Omar Suhana , Jolánkai Márton , Tarnawa Ákos , Khalid Noriza , Kassai Mária Katalin , Kende Zoltán
Published: October 2023

The practice of cultivating crops in a controlled environment using a soilless culture method is seeing an increasing level of popularity. The aforementioned challenges include addressing climate change, combating pests and diseases, mitigating falling soil fertility, and ensuring constant production and quality. One of the potential crops that could be grown with such a method is soybean. Soybean cultivation in a controlled environment using soilless culture still needs more information, especially regarding nutrient solution management of certain soybean varieties. Thus, this study investigated the impact of nutrient concentrations and variety on soybean growth, yield, and chemical composition. This research was carried out in a plant growth chamber using expanded clay aggregate as a soilless substrate. The treatments were four nutrient concentrations: 0% (control), 50%, 100%, and 150%, and two different varieties: Martina and Johanna. The findings of this research revealed that there were significant differences in nutrient treatments on all parameters measured. Application of nutrient concentration at 50% resulted in the most profound root size for both varieties. Applying 100% nutrient concentration produced a higher 100-grain weight for the Johanna variety. Application of nutrient concentration at 150% resulted in the highest shoot weight and shoot:root ratio for both varieties, with varietal differences. Furthermore, applying nutrient concentration at 150% also produced the highest grain yield/pot, protein yield, and lipid yield for both varieties. Thus, the nutrient concentration between 100% and 150% gave a positive effect and can be applied for planting Martina and Johanna using this system.
Evaluation System for Agricultural and Rural Modernization in China
Authors: Yan Zhoufu , Peng Lewei , Wu Xiao
Published: October 2023

High-quality development of agricultural and rural areas is the foundation of national modernization and sustainable development in China. Therefore, the evaluation of the degree of development of modernization of China’s agricultural and rural areas and the summarization of its main characteristics are crucial. However, studies on rural modernization and coordinated development are limited. Here, we developed a statistical evaluation system to effectively identify and assess the levels of agricultural and rural modernization, urban–rural integration, and agricultural rural coordination. We found that agricultural and rural modernization in China has continued to improve, but low scores were attributed to the factors of coordinated development of urban–rural areas, livable ecological environment, farmer prosperity, industrial structure upgrade, and resource allocation efficiency, limiting high-quality agricultural and rural development. Agricultural and rural modernization is lower in the central and western regions, compared to that in the eastern regions, but it is picking up the pace, indicating convergence. Rural modernization is lower than agricultural modernization and the two subsystems are not sufficiently coordinated, especially in undeveloped areas. Furthermore, the regional differences in rural modernization are greater than those in agricultural modernization. The system developed here can provide valuable experience for developing countries to open new paths toward modernization.
Incidence of Rifampicin Resistance in Periprosthetic Joint Infection: A Single-Centre Cohort Study on 238 Patients
Authors: Lazarinis Stergios , Hailer Nils P. , Järhult Josef D. , Brüggemann Anders
Published: October 2023

Background. Rifampicin is a pillar in the treatment of periprosthetic joint infection (PJI). However, rifampicin resistance is an increasing threat to PJI treatment. This study explores the incidence of rifampicin-resistant bacteria over time in a Swedish tertiary referral centre and the association of rifampicin resistance with infection-free survival after PJI. Methods. The study included 238 staphylococcal PJIs treated between 2001 and 2020 for which susceptibility data for rifampicin were available. Data on causative bacteria, rifampicin resistance, treatment, and outcome were obtained. Kaplan–Meier survival analysis and Cox regression modelling estimated the infection-free cumulative survival and adjusted hazard ratios (HRs) for the risk of treatment failure. Results. Rifampicin-resistant causative bacteria were identified in 40 cases (17%). The proportion of rifampicin-resistant agents decreased from 24% in 2010–2015 to 12% in 2016–2020. The 2-year infection-free survival rates were 78.6% (95% CI, 66.4–93.1%) for the rifampicin-resistant group and 90.0% (95% CI, 85.8–94.4%) for the rifampicin-sensitive group. Patients with PJI caused by rifampicin-resistant bacteria had an increased risk of treatment failure (adjusted HR, 4.2; 95% CI, 1.7–10.3). Conclusions. The incidence of PJI caused by rifampicin-resistant bacteria did not increase over the past 20 years. The risk of treatment failure in PJI caused by rifampicin-resistant bacteria is more than four times that caused by rifampicin-sensitive bacteria, highlighting the importance of limiting the development of rifampicin resistance.