bluuebunny/crossref_metadata_2025 huggingface dataset:
Historical Topics on "December Dialogues"
Authors: Tomilov N.A.
Published: November 2024

Data on the 20th all-Russian scientific conference “December Dialogues” of F. V. Melekhin, which took place on December 6-7, 2016 in Omsk, as well as information on reports on historical and historical and cultural topics.
All-Russian Scientific-Practical Conference "IX Historical Readings in Memory of Mikhail Petrovich Gryaznov"
Authors: Tolpeko I.V.
Published: November 2024

Provides information about all-Russian scientific-practical conference “IX historical readings in memory of Mikhail Petrovich Gryaznov”. The event was organized by the Dostoevsky Omsk State University and Omsk branch of the Institute of Archaeology and Ethnography Siberian branch of the Russian Academy of Sciences and held from 22 to 24 March 2017.
The Origin and Genealogical Links of Military and Ministry Families of Nemtchinov: Tara Region, XVII-XVIII Centuries
Authors: Krikh A.A.
Published: November 2024

Nemchinovs - one of the oldest Siberian names repeatedly attracting the interest of researchers. Despite the impressive bibliography on the history of the Tara's Nemchinovs, many questions related to their origins and genealogy remain unresolved. In this study proved the relationship between one of the leaders of the Tara's rebellion of 1722 Ivan Gavrilovich Nemchinov and the gold merchant Yakov Andreevich Nemchinov.
Using simulation to find the best reliability of the Generalized Exponential Distribution
Authors: Amer Abdul Ameer Huda
Published: November 2024

The generalized exponential distribution is one of the most widely used distributions in the field of geometric reliability. Also, it can be used as an alternative to the Gamma or Weibull distribution in many cases. The goal of this paper is to find the best reliability function for the shape parameter  of the Generalized Exponential Distribution using different methods (classical and Bayes) by using two non–information prior (Jeffery and Modify Jeffery) with different loss functions (squared error and Precautionary). The Reliability is based on the Monte Carlo study to using the simulation of the Reliability study on the performance of these estimations by using the mean square error.
Leveraging soft infrastructure for agricultural development: A policy perspective on technology adoption among agricultural extension officers in West Java
Authors: Dewijanti Indra Irjani , Hapsari Hepi , Setiawan Iwan , Wulandari Eliana
Published: November 2024

Technological advancements are transforming agriculture, yet adoption rates among agricultural extension officers, especially in regions like West Java, remain modest due to several challenges. This study applies the Technology Acceptance Model (TAM) to investigate factors influencing the adoption of agricultural technologies by agricultural extension officers in West Java. Specifically, we explore the role of socialization, training, access to technology, cost, perceived ease of use, and perceived usefulness in shaping behavioral intention and actual adoption. Data were collected from 295 agricultural extension officers via structured surveys and analyzed using SmartPLS 4 software. The findings indicate that socialization and training collectively enhance both perceived ease of use and perceived usefulness, while Technology Investment Worth specifically enhances perceived usefulness by emphasizing the value of the investment. Access to technology also plays a critical role in increasing ease of use perceptions. Both perceived ease of use and usefulness positively influence behavioral intention, which in turn is a strong predictor of actual adoption. The results provide valuable insights for policymakers aiming to increase technology uptake among agricultural extension officers, promoting sustainable agricultural practices through improved access, support, and cost reduction initiatives.
Novel methodology & optimization of heat pump efficiency through stochastic finite element analysis and circular statistics
Authors: Chatterjee Debashis , Saha Subhrajit
Published: November 2024

This research introduces a novel framework integrating stochastic finite element analysis (FEA) with advanced circular statistical methods to optimize heat pump efficiency under material uncertainties. The proposed methodologies and optimization focus on balancing the mean efficiency and variability by adjusting the concentration parameter of the Von Mises distribution, which models directional variability in thermal conductivity. The study highlights the superiority of the Von Mises distribution in achieving more consistent and efficient thermal performance compared to the uniform distribution. We also conducted a sensitivity analysis of the parameters for further insights. The results show that optimal tuning of the concentration parameter can significantly reduce efficiency variability while maintaining a mean efficiency above the desired threshold. This demonstrates the importance of considering both stochastic effects and directional consistency in thermal systems, providing robust and reliable design strategies.
Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids
Authors: Poje Goran , Šakić Davor , Marinović Marina , You Jiangyang , Tarpley Michael , Williams Kevin P. , Golub Nikolina , Dernovšek Jaka , Tomašič Tihomir , Bešić Erim , Rajić Zrinka
Published: November 2024

The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated their antiglioblastoma potential in vitro and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). The results have shown that triazole-type harmicens, namely 5, with a ferrocene moiety in C-3 position of the β-carboline ring (IC
50 = 3.7 ± 0.1 µmol L–1, SI = 12.6) and ., the C-6 substituted harmicene (IC
50 = 7.4 ± 0.5 µmol L–1, SI = 5.8) exert remarkable activity and selectivity against human malignant glioblastoma cell line (U251) in vitro. On the other hand, amide-type harmicens 10, 12, and 14 exhibited strong, but non-selective activity, in the low micro-molar range. Mechanistic studies revealed that among active compounds, amide-type harmicens 12 and 14 inhibit DYRK1A and Hsp90 CTD, whereas compound 14 showed pronounced antioxidative activity. Therefore, the antiproliferative activity of harmicens might be a combination of complex molecular interactions.
On the Dirichlet Problem for a Class of Nonlinear Degenerate Elliptic Equations in Weighted Sobolev Spaces
Authors: Cavalheiro Albo Carlos
Published: November 2024

In this paper we are interested in the existence of solutions for the Dirichlet problem associated with the degenerate nonlinear elliptic equations

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Perceived Quality of Healthcare Services, a Particular Case - Cardiology
Authors: Neamtu Dragos , Purcarea Victor Lorin
Published: November 2024

This study emphasizes the importance of evaluating and managing quality in the field of healthcare services, especially within cardiology services, where service quality is vital. We focused on an important aspect: measuring patients' perception of service quality.

Materials and Methods: For this study, a randomly selected number of 143 patients who visited the cardiology clinic were chosen. The research methodology involved conducting a quantitative study, with data collected using a questionnaire distributed to patients with cardiovascular diseases who visited our unit. The questionnaire comprised 32 questions.

For data analysis, statistical analysis was performed using IBM SPSS Statistics 25 and Microsoft Office Excel/Word 2021. Additionally, 20 articles from international journals were systematically reviewed to identify factors influencing patient satisfaction and healthcare service quality.The results indicated that patients were satisfied with how staff cared for their needs, being treated respectfully and fairly, without discrimination based on various criteria, and patient rights were respected. Qualitative variables were expressed in absolute terms or as percentages.

Conclusions: According to the study results, the majority of patients reported positive experiences during clinic visits, perceiving service quality to be high.
The Role of the European Union’s Neighbourhood Policy in Developing Cross-Border Cooperation in the Polish-Ukrainian Borderland
Authors: Studzieniecki Tomasz , Szyda Monika , Szelągowska-Rudzka Katarzyna
Published: November 2024

Cross-border cooperation, financially supported by the EU Neighbourhood Policy instruments, is an important factor for the socio-economic development of cross-border areas at the EU’s external borders. This paper is devoted to cross-border cooperation on the Polish-Ukrainian border, which was financed by the Cross-Border Cooperation Program Poland-Belarus-Ukraine 2014–2020, which was one of the programs of the European Neighbourhood Policy. This issue becomes particularly significant in the context of cooperation with Ukraine, which is challenging due to the ongoing conflict in its territory. There is a need to examine existing solutions and propose future directions for cross-border cooperation. The aim of the article was to present evolution and identify the attributes of the European Neighbourhood Policy, which is a key instrument of the development of cross-border cooperation at the EU’s external borders. The second aim was a multidimensional analysis of Polish-Ukrainian cooperation during a period 2014–2020, taking into account the structure of projects, partners and areas of cooperation. The structure of partners was examined and discussed based on their status, sector, and level of activity. The research augmented the current knowledge in the field of cross-border collaboration supported by the European Neighbourhood Policy. The management of cross-border cooperation on the Polish-Ukrainian border can benefit from the study’s practical conclusions.
Coping with Perplexities: How to Make Human Rights Education Sustainable
Authors: Franzenburg Geert
Published: November 2024

On 23 December 1994, the UN General Assembly adopted a plan of action for the United Nations decade for human rights education (HRE). 30 years later, this challenge is still increasing. As Hannah Arendt pointed out, human rights are valuable only as political rights, not for abstract individuals but for natural communities. While HRE in schools and classrooms is in focus, the context of adult education transfers philosophical and political thoughts into an educational context, particularly concerning biographical traumatic situations such as refuge and expulsion. Therefore, this paper presents and explains adult education approaches which facilitate coping strategies with ethical perplexities by evaluating the 30 Articles of the UNO Declaration of Human Rights of 1948.
Priority-based resource allocation in layering LoRaWAN
Authors: Balyan Vipin
Published: November 2024

Network applications for the Internet of Things (IoT) frequently use Long-Range (LoRa) technology. It allows tiny wireless devices to transmit data at low volumes. The idea behind LoRa networks, or Low-Power Wide Area Networks (LPWAN), is to use airborne data transmission from sensors with a transmission range of no more than 10 km. These sensors run on batteries and should not be connected to the electrical grid. Because of the benefits of Long-Range Wide Area Network (LoRaWAN) private networks, users have implemented various services in a single LoRaWAN system to realize a range of intelligent applications. LoRaWAN faces difficulties with multiservice coexistence as the number of applications grows because of insufficient channel resources, disorganized network configuration, and scalability problems. Creating a sensible plan for allocating resources is the best course of action. Nevertheless, current methods are inapplicable to LoRaWAN systems that support several services with varying criticalities. To coordinate multiservice networks, we therefore suggest a priority-based spreading factor (SF) allocation delay monitoring layered (DML) resource allocation scheme. The three primary categories of LoRaWAN application services—monitoring, control, and safety—are outlined in this paper. The suggested prioirty based resource allocation (PB-RA) scheme distributes SFs to end devices according to the highest priority parameter, taking into account the varying criticalities of these services. This increases throughput, lowers energy consumption, and increases packet delivery rate (PDR). The main advantage associated with using it is that priority is given to applications that require safety without introducing latency in other applications.
Evaluation of the relative density based on flat dilatometer test
Authors: Lech Mariusz , Bajda Marek , Markowska-Lech Katarzyna , Rabarijoely Simon
Published: November 2024

Overseeing the relative density of soils in all types of earth structures during both construction and operation is crucial to ensure that these structures attain the necessary density and strength. Especially in linear structures that extend over significant lengths, geotechnical investigations should include planning tests that allow for determining the maximum number of geotechnical parameters, such as cone penetration tests (CPTU) or Marchetti dilatometer tests (DMT). The article presents the in situ tests aimed at assessing the relative density of sandy soils. Empirical formulas available in the literature for determining the relative density Dr from DMT gave inconsistent results compared to those obtained from dynamic soundings, especially in the near-surface zone, where high KD readings significantly overestimate relative density values. Assuming the results of DPL probe tests as reference values, a formula for the compaction index based on DMT soundings has been proposed. In contrast to the formulas commonly used in the literature, the proposed formula for the relative density depends not only on the horizontal stress index KD, but also on the dilatometer modulus ED.
Civilsamhällesorganisering för nyanlända i Malmö
Authors: Lundstedt Måns
Published: November 2024

Cooperation between civil society and the public sector have long played a central role in migrants’ integration. This text explores what that relation has been like in the past, in the present, and what it might look like in the future, based on an interview with Mikael Johansson, representative of the umbrella organization Malmö ideella. While the text’s main focus is relations within the city of Malmö, the discussion is broadened to encompass more general conditions in contemporary Sweden.
Color categorization as a cultural schema
Authors: Nankevich Alyona Anvarovna
Published: November 2024

The relevance and novelty of this study is determined by its purpose, which is to analyze color categorization as a cultural schema. Color categorization is understood as a way of dividing the color continuum into discrete areas (color categories), which society then endows with cultural connotations and includes in the general system of cultural knowledge. According the mentioned purpose, the concept of “cultural schema” was considered, the structure of color categorization as a cultural schema was designated and an analysis of its consistent inheritance and genesis in culture was presented. To reveal the main stages of the color categorization genesis and its typological characteristics, the ternary model of culture by A. V. Kostina and A. Ya. Flier was used. Based on the identified specificity of the interaction of three functional types of culture (consumer, traditional and creative), two types of color categorization are distinguished: natural and artificial. Natural color categorization is the historically first way of classifying color, which develops as nature is imitated (natural classes of colors) and dyes available to people are mastered. An important result of the accumulation and production of new knowledge in the field of color is the formation of a taxonomy of color terms in natural language, as well as the establishment of color categorization in everyday human consciousness in the form of cultural norms and customs, for example, the division of colors into “male” and “female” or into “festive” and “everyday” in religious clothing. As cultural practices associated with color develop, artificial color categorization arises against the background of natural color categorization. Its main distinguishing feature is a completely controlled process of obtaining color and codification of color relations in the form of atlases and color systems.
Implementations of the Universal Birkhoff Theory for Fast Trajectory Optimization
Authors: Proulx Ronald J. , Ross Isaac M.
Published: November 2024

This is Part II of a two-part paper. Part I presented a universal Birkhoff theory for fast and accurate trajectory optimization. The theory rested on two main hypotheses. In this paper, it is shown that if the computational grid is selected from any one of the Legendre and Chebyshev families of node points, be it Lobatto, Radau, or Gauss, then the resulting collection of trajectory optimization methods satisfies the hypotheses required for the universal Birkhoff theory to hold. All of these grid points can be generated at an [Formula: see text] computational speed. Furthermore, all Birkhoff-generated solutions can be tested for optimality by a joint application of Pontryagin’s- and covector-mapping principles, where the latter was developed in Part I. More importantly, the optimality checks can be performed without resorting to an indirect method or even explicitly producing the totality of necessary conditions that result from an application of Pontryagin’s principle. Numerical problems are solved to illustrate all these ideas in addition to demonstrating near-exponential rates of convergence. The examples are chosen to particularly highlight three practically useful features of Birkhoff methods: 1) bang-bang optimal controls can be produced without suffering any Gibbs phenomenon, 2) discontinuous and even Dirac delta covector trajectories can be well approximated, and 3) extremal solutions over dense grids can be computed in a stable and efficient manner.
Implementación de un control de calidad de paciente específico en tratamientos de radioterapia con ArcCheck
Authors:   UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS, Mamani Gabina , Zeladita Huaman Jhon Alex ,   Universidad Nacional Mayor de San Marcos, Lima-Perú, Montes Iturrizaga Ivan ,   Universidad Continental. Arequipa, Carpio Borja Sugely Julia ,   Universidad Nacional Mayor de San Marcos, Lima-Perú
Published: November 2024

Introduction: There are few studies that evaluate the worry and fear of covid-19 in healthcare professionals who work in emergency services in low- and middle-income countries. Objective: To characterize the concern for contagion and fear of covid-19 in Peruvian nurses who work in emergency services. Materials and methods: Comparative descriptive, correlational and cross-sectional study. 212 nurses were surveyed in 2021. The correlation coefficient of Pearson and ANOVA test were used. Results: Regarding concern, 41% often think about the probability of getting infected, 45.3% consider that it affected their state of mind, but 82.5% estimated that they had not affected their work abilities. On the other hand, 34.4% strongly agree that they are very afraid and 35.3% are very afraid of losing their lives. In addition, the comparative analysis by item reported that women, those who do face-to-face work, and those who had not received vaccinations show a lower frequency in some items of concern; while men, who do face-to-face work and who have only one dose of the vaccine, have a higher frequency in the fear items. Discussion: The results refer us to a problem little studied in Latin America and makes it possible to understand that nurses are emotionally affected by sanitary conditions. Conclusions: The nurses who work in the emergency services present a medium level of both concern about contagion and fear of COVID-19.
Vitamin D intoxication-induced hypercalcemia in a geriatric patient: a case report
Authors:   Facultad de Medicina Humana, Universidad Peruana Los Andes, Huancayo, Perú., Dextre-Vilchez Sergio Armando , Caira-Chuquineyra Brenda ,   Facultad de Medicina, Universidad Nacional de San Agustín de Arequipa. Arequipa, Perú., Dextre-Vilchez Sofia Raquel ,   Facultad de Medicina Humana, Universidad Peruana Los Andes. Huancayo, Perú.
Published: November 2024

Introduction: Hypercalcemia secondary to vitamin D intoxication is a rare condition resulting from inadequate prescription. It is characterized by nonspecific symptomatology and can produce severe neurological, muscular, gastrointestinal, renal, and cardiovascular manifestations. Clinical case: We describe the case of an 86-year-old woman with a history of vitamin D supplementation for three months after hip arthroplasty. The initial presentation was gastrointestinal symptoms and sensorimotor disturbance. Hypercalcemia was found upon evaluation. After ruling out the main organic causes, vitamin D intoxication was suspected, which was confirmed after testing for 25-hydroxyvitamin D levels. Correction of hypercalcemia was performed, and the patient had a favorable clinical evolution. Conclusion: It is important to consider vitamin D intoxication as a differential diagnosis of hypercalcemia in geriatric patients and to ensure adequate monitoring of the prescription of vitamin supplements.
Implementación de un control de calidad de paciente específico en tratamientos de radioterapia con ArcCheck
Authors:   Universidade Federal de Ciências da Saúde de Porto Alegre, Alva Sánchez Mirko Salomón , Linhares Isabela ,   Curso de Bacharelado em Física Médica, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brasil, Maulaz Carolina ,   Departamento de Radioterapia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil, Frohlich Bruna ,   Departamento de Radioterapia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil, Scheid Artur ,   Departamento de Radioterapia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil, Fischer Matheus ,   Departamento de Radioterapia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil, Martins Dias Telpo ,   Departamento de Radioterapia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil, da Rocha Estácio Daniela ,   Departamento de Radioterapia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasi
Published: November 2024

Introduction: Quality control is essential to ensure safety and prevent errors in the administration of ionizing radiation across various radiotherapy techniques. Objective: To evaluate the performance of the ArcCheck detector with the goal of implementing a specific quality control technique for patients treated with dynamic arc therapy. Methods: Fifty patients treated with 6 MV and 10 MV energies on the Clinac® Varian CX were selected. Doses at the isocenter of each treatment plan were analyzed using a PMMA phantom (30 x 30 x 15 cm³) to validate reference values between the treatment planning system and the ionization chamber. The treatment plans were also recreated using the ArcCheck. Results: The mean dose difference at the isocenter was -0.96% and -1.34% for 6 MV and 10 MV, respectively. The average passing rate of the dose distributions in the gamma analysis exceeded 98.0% for both energies. Conclusion: The results demonstrated good concordance with the TG-119 and TG-218 protocols, supporting the use of the detector for quality control in patient-specific treatments.
Mixed reality in surgical mechatronics: Innovations and challenges in bioengineering education and clinical practice
Authors:   Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú, Nacarino Adrian , La-Rosa Anderson ,   Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú, Sanchez Bryan ,   Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú, Cornejo Jose ,   Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú, Vargas Mariela ,   Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú, Cornejo Jorge ,   Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú, Palomares Ricardo ,   Grupo de Investigación en Robótica y Mecatrónica Avanzada (GI-ROMA), Universidad Ricardo Palma, Lima, Perú.
Published: November 2024

Background: Mixed reality (MR), a combination of augmented reality (AR) and virtual reality (VR), has emerged as a key tool in surgical mechatronics, improving precision and visualization in clinical procedures. Methods: This study presents a literature review of recent MR advances from the Scopus database, taking into account its impact on surgery and medical education. Technologies such as Microsoft HoloLens and Magic Leap, as well as neurosurgery and orthopedic simulators, are reviewed. Results: MR enhances surgical precision and reduces operating times, with an average decrease from 121.34 to 97.62 minutes. Despite its potential, challenges include discomfort from prolonged device use and low battery autonomy. Conclusions: MR has the potential to transform surgery and medical education; however, its widespread adoption will depend on overcoming technological and financial barriers, especially in Latin America, where infrastructure is still limited.
Diskursus Pemenuhan Kesejahteraan Hakim Sebagai Pencegahan Judicial Corruption Melalui Rancangan Undang-Undang Jabatan Hakim: Studi Komparatif Dengan Negara Amerika dan Kanada
Authors: Daffa Ladro Kusworo  , Maghfira Nur Khaliza Fauzi
Published: November 2024

Kesejahteraan hakim dalam upaya penyediaannya mengalami stagnasi yang berpengaruh terhadap integritasnya. Masalah yang kian kompleks sebenarnya bermula dari regulasi yang saat ini belum dapat mengakomodir seluruh hak keuangan dan fasilitas hakim. Misalnya saja dalam dinamika terkait besaran gaji pokok dan tunjangan di PP Nomor 94 Tahun 2012 sampai pada perubahan pertamanya masih dikatakan sangat minim, begitu juga Putusan Nomor 23 P/HUM/2018 yang mencabut besaran gaji pokok hakim dengan Pegawai Negeri Sipil (PNS) tetapi tidak ada tindak lanjut pasca putusan untuk membentuk payung hukum. Intervensi finansial tentu akan berpotensi besar terjadi di kalangan hakim, manakala efektivitas hadir akibat kurangnya negara dalam menjamin kesejahteraan hakim, sehingga kemudian hari keputusan yang diberikan berdasar seberapa besar finansial yang ditawarkan oknum-oknum melalui transaksional yang mengarah pada korupsi peradilan. Metode penelitian menggunakan yuridis normatif mengacu pada peraturan-undangan serta kajian kepustakaan berupa buku-buku, jurnal, dan literatur lainnya. Penelitian bersifat preskriptif untuk menemukan gagasan ideal diiringi studi perbandingan untuk menelaah sistem hukum di negara lain. Hasil penelitian menunjukkan bahwa problematika sistem penggajian hakim, serta peraturan yang terbatas perlu mencontoh Amerika yang menerapkan perlindungan gaji konstitusional dan larangan kongres menurunkan gaji hakim. Sementara di Kanada terdapat fungsi komisi yudisial untuk melakukan investigasi terkait kecukupan gaji dan jumlah lainnya yang harus diungkapkan kepada hakim yang ditunjuk pemerintah secara berkala. Konstruksi pengaturan hak keuangan dan fasilitas hakim perlu memperhatikan prinsip remunerasi yudisial dan penelitian terkait pengaruhnya terhadap peningkatan kinerja, untuk nantinya diakomodasi dalam RUU Jabatan Hakim sebagai payung hukum guna meningkatkan kesejahteraan hakim di Indonesia.
Oncogene 5’-3’ exoribonuclease 2 enhances epidermal growth factor receptor signaling pathway to promote epithelial–mesenchymal transition and metastasis in non-small-cell lung cancer
Authors: Cheng Yonghui , Wen Mengge , Wang Xiaochun , Zhu Hao
Published: November 2024

Objective:

Epithelial–mesenchymal transition (EMT) and metastasis are the primary causes of mortality in non-small-cell lung cancer (NSCLC). 5’-3’ exoribonuclease 2 (XRN2) plays an important role in the process of tumor EMT. Thus, this investigation mainly aimed to clarify the precise molecular pathways through which XRN2 contributes to EMT and metastasis in NSCLC.

Material and Methods:

Western blot and quantitative real-time polymerase chain reaction were first used to assess XRN2 levels in NSCLC cells. Subsequently, short hairpin RNA-XRN2 (Sh-XRN2) and XRN2 overexpression (Ov-XRN2) plasmids were transfected to NSCLC cells. The effects of Sh-XRN2 and Ov-XRN2 on NSCLC cell migration and invasion were evaluated by Transwell assay. Western blot experiments were conducted to assess the effects of Sh-XRN2 and Ov-XRN2 on proteins related to EMT and the epidermal growth factor receptor (EGFR) signaling pathway in H460 cells. Then, Sh-XRN2 and EGFR overexpression (Ov-EGFR) plasmids were transfected to NSCLC cells. Changes in NSCLC cell migration and invasion were measured using a Transwell assay with Sh-XRN2 and Sh-XRN2+Ov-EGFR. Changes in the expression of proteins related to EMT in NSCLC cells were detected by Western blot assays with Sh-XRN2 and Sh-XRN2+Ov-EGFR. Furthermore, a subcutaneous tumor model for NSCLC was established. Immunohistochemical analysis was performed to assess the levels of Cluster of Differentiation 31 (CD31) in lung metastatic lesions. H460 cells transfected with Sh-XRN2, Ov-XRN2 or Sh-XRN2+Ov-EGFR were co-cultured with human umbilical vein endothelial cells (HUVECs) to assess the tube formation ability of the cells.

Results:

Compared with those observed in human bronchial epithelial cells (BEAS-2B cells), XRN2 expression levels were significantly upregulated in NSCLC cell lines (H460 cells) (P < 0.001). XRN2 overexpression considerably promoted the NSCLC cell migration and invasion, EMT process, and tube formation ability of HUVECs (P < 0.001). On the contrary, XRN2 knockdown led to a reduction in these processes. In addition, XRN2 overexpression increased the expression levels of CD31 in lung metastatic lesions and activated the phosphorylation of EGFR signaling pathway (P < 0.001). Furthermore, Sh-XRN2+Ov-EGFR significantly promoted migration, invasion, and EMT processes in H460 cells (P < 0.001). In the meantime, compared with the co-H460+Sh-XRN2+Ov-NC group, co-H460+Sh-XRN2+Ov-EGFR significantly enhanced the tube formation ability of HUVECs (P < 0.001).

Conclusion:

XRN2 promoted EMT and metastasis in NSCLC through improving the phosphorylation of the EGFR signaling pathway in NSCLC cells.
Chronic Kidney Disease of Unknown Etiology in Telangana: Is It Different?
Authors: Ramavajula Anitha , Sahay Manisha , Ismal Kiranmai , Kavadi Anuradha , Enganti Rama , Gowrishankar Swarnalata
Published: November 2024

Background

Chronic kidney disease of unknown etiology (CKDu) is emerging as an important cause for CKD in various parts of the world, including India. This study was done to determine the risk factors and histology of CKDu in Telangana, a neighboring state of Andhra Pradesh that has CKDu hotspots.

Materials and Methods

This prospective observational study was done from March 2021 to November 2022 at a tertiary care center in Hyderabad. Patients were included as per the Indian CKDu definition. Sociodemographic data, examination, and investigations were obtained. Drinking water was analyzed. Patients with preserved kidney sizes underwent kidney biopsy. Patients were followed up with estimated glomerular filtration rate (eGFR) at 0.6 months and one year.

Results

A total of 75 patients were studied. Mean age was 41.72 +/- 13.59 years, where 68% were males. Groundwater was the drinking water source for 77.3%. In all, 40% had consumed alternate medicine and 46.6% patients had undergone kidney biopsy. The main findings were global glomerulosclerosis (>50%) in 54%, 31% had >50% interstitial fibrosis and tubular atrophy, 34.3% had periglomerular fibrosis, and 85.7% had interstitial inflammation. Hypertension was a significant risk factor for progression.

Conclusion

Our study results were like other Indian studies in terms of affecting younger male population, but differed from these studies as the majority of our patients came from nonagricultural backgrounds. Herbal medicine intake was a major risk factor. A vast majority of patients had chronic tubulointerstitial nephritis in biopsy at presentation, showing that most presented late.
Platelets: The unsung heroes in the battle against tuberculosis – A comprehensive review of platelet indices as diagnostic beacons and pathophysiological players
Authors: Garg Rahul
Published: November 2024

This review explores the emerging role of platelet indices in tuberculosis (TB) as potential biomarkers for diagnosis, disease monitoring, and understanding pathogenesis. Platelet count, mean platelet volume, platelet distribution width, and plateletcrit have shown significant alterations in TB patients compared to healthy controls and those with other respiratory conditions. These changes are attributed to the inflammatory response, direct platelet activation by Mycobacterium tuberculosis, and involvement in granuloma formation. Recent studies have investigated the diagnostic and prognostic value of platelet indices in TB, including their potential for differentiating TB from other respiratory infections, monitoring treatment response, and assessing disease severity. However, challenges such as lack of specificity and measurement variability need to be addressed. The review also highlights the multifaceted role of platelets in TB pathogenesis, including immune modulation and antimicrobial functions. Future research directions include large-scale validation studies, exploration of combined biomarker panels, and investigation of platelet indices in pediatric TB and TB-diabetes comorbidity. As our understanding of platelet-TB interactions grows, these indices may contribute to more personalized and effective TB management strategies.
Isolated fungal liver abscess in pediatric acute lymphoblastic leukemia – A case report
Authors: Benson Reshma , Kumar Karthik , Prasad Amber , Nath Uttam Kumar
Published: November 2024

Diagnosis and management of invasive fungal infections pose a challenge to the treating physician in patients with hematological malignancies. The incidence is lesser in acute lymphoblastic leukemia (ALL), compared to the other hematological malignancies. The diagnosis is often delayed due to the non-specific clinical findings and negative cultures. Here, we report a case of B-cell ALL, on chemotherapy, diagnosed to have hepatic fungal abscess caused by Aspergillus fumigatus species. Interestingly, the patient did not have neither neutropenia nor any other systemic involvement of fungal infection at presentation. The case was successfully managed with percutaneous drainage and systemic antifungal therapy using voriconazole. Timely intervention helped in the diagnosis and proper management of the case, thus preventing a disseminated invasive fungal infection.
Программный комплекс визуализации цифровой модели керна
Authors: М.В. Михайлюк , П.Ю. Тимохин , И.Н. Мироненко
Published: November 2024

В статье описывается разработанная в ФГУ ФНЦ НИИСИ РАН альфа-версия программного комплекса визуализации цифровой модели керна, полученной с помощью рентгеновской компьютерной томографии. Созданный комплекс позволяет визуализировать в масштабе реального времени поровое пространство в выделенном объеме цифровой модели керна, синтезировать изображения поперечных сечений цифровой модели керна, исследовать структуру модели керна с помощью кросс-сечений. Комплекс включает в себя разработанную графическую оболочку, позволяющую эффективно объединять в единую систему различные методы визуализации и расширять ее новыми методами. Была проведена успешная апробация разработанного комплекса на цифровой модели образца керна баженовской свиты, которая подтвердила корректность предлагаемых решений и их применимость в исследованиях специалистов нефтегазовой отрасли.

The paper describes developed in SRISA RAS alpha-version of a program complex for visualization of digital model of the core material, obtained by means of X-ray computed tomography. The complex created allows the pore space in the allocated volume of core model to be visualized in real-time, to synthesize images of transverse sections of the core model, and to investigate the structure of the core model using cross-sections. The complex comprises a developed graphical shell allowing various visualization methods to be effectively combined into a single system and expand this system with new ones. A successful approbation of the complex developed, using digital model of the core sample of Bazhenov suite, was carried out. It confirmed the correctness of the solutions proposed and their applicability in researches of the specialists of oil and gas industry
Инструментарий подготовки блочно-структурированной сетки для проведения расчетов методом RANS/ILES
Authors: Л.А. Бендерский , Д.А. Любимов , А.А. Рыбаков
Published: November 2024

Метод RANS/ILES с явным разрешением турбулентных вихрей успешно применяется для расчета нестационарных турбулентных течений. Применение данного метода требует большого количества вычислительных ресурсов, которое может обеспечить только суперкомпьютер. При использовании суперкомпьютера остро встает вопрос распараллеливания вычислений и их масштабирования на расчетные сетки, содержащие большое количество ячеек. В данной статье описываются подходы к подготовке блочно-структурированной расчетной сетки, позволяющие эффективно проводить вычисления на суперкомпьютере с использованием RANS/ILES метода.

The RANS/ILES method with an explicit resolution of turbulent vortices is successfully used to calculate nonstationary turbulent flows. The application of this method requires a large amount of computing resources, which can be provided only by a supercomputer. When using a supercomputer, the problem of parallelizing computations and their scaling to computational grids containing a large number of cells is acute. This article describes approaches to the preparation of a block-structured computational grid, which allow efficient calculation on a supercomputer using the RANS/ILES method
О цифровой экономике
Authors: С.Г. Романюк
Published: November 2024

В 2017 году Правительством России была принята программа перехода к цифровой экономике, однако во многих публикациях признаётся, что общепринятого определения термина «цифровая экономика» не существует. В статье говорится о том, какой смысл может приобрести словосочетание «цифровая экономика», если отталкиваться от значения слова «цифровая», в котором оно употребляется в информатике и вычислительной технике, и какие из этого могут быть сделаны практические выводы.

In 2017, the Government of Russia adopted a program of transition to the digital economy, but many publications recognize that there is no generally accepted definition of the term "digital economy". The article describes the meaning of the word "digital economy" if we start from the meaning of the word "digital", in which it is used in computer science and computer engineering, and what practical conclusions can be drawn from this.
Влияние мощностей потребления и температуры окружающей среды на интервально-стохастические тепловые процессы в электронном модуле
Authors: М.Ж. Акжолов , П.И. Кандалов
Published: November 2024

В статье рассматривается компьютерное и математическое моделирование интервально стохастических нестационарных тепловых процессов в электронных системах. На основе разработанного метода [1], получена система матрично-дифференциальная уравнений для электронной системы, выполнен-ной из герметичного корпуса с расположенным внутри электронным модулем. Проведено численное модели-рование с применением метода Рунге-Кутта 4-го порядка. Проанализированы временные зависимости мате-матического ожидания и дисперсии стохастической температуры электронного модуля от величин темпера-туры окружающей среды и мощности потребления

The article deals with mathematical and computational modeling of interval stochastic unstady-state thermal processes in electronic systems. The authors based on [1] derived a matrix system of differential equations for electronic system which consists of hermetic enclosure and electronic module located inside. Numerical simula-tion are carry out using four order Runge-Kutta method. The time-dependences of the expectation value and variance of the stochastic value from ambient temperature and power consumption are analyzed.
Тепловой режим микросхемы в условиях неопределенности определяющих параметров и воздействии тепловой обратной связи
Authors: А.Г. Мадера
Published: November 2024

Рассматривается тепловой режим интегральной полупроводниковой микросхемы в условиях неопределенности значений параметров теплового режима микросхем и воздействии тепловой обратной связи. Метод анализа основан на решении уравнения математической макромодели микросхемы относительно усредненной стохастической температуры кристалла и полученных аналитических выражений для математического ожидания и дисперсии температуры. Показано, что совместное воздействие тепловой обратной связи и интервально-стохастической неопределенности параметров микросхемы оказывает значительное влияние на температуру микросхемы, а пренебрежение указанными факторами может приводить к значительным ошибкам при проектирования микросхем и электронных устройств на их основе

The thermal mode of an integrated circuit is considered under conditions of uncertainty of the values of the parameters of the thermal mode of the integrated circuit and the effect of thermal feedback. The analysis method is based on solving the equation of a mathematical macro model of a integrated circuit with respect to the average stochastic temperature of the chip and the resulting analytical expressions for the expectation and dispersion of the temperature. It is shown that the combined effect of thermal feedback and interval-stochastic uncertainty of the integrated circuit parameters has a significant impact on its temperature and neglecting these factors can lead to significant errors in designing chips and electronic devices based on them.
Составление многопроцессорного расписания для неоднородного множества работ с дополнительным ресурсом
Authors: М.Г. Фуругян
Published: November 2024

Решается задача составления расписания выполнения неоднородного набора заданий в системе с несколькими идентичными приборами и не возобновляемым ресурсом. Часть заданий являются прерываемыми, а часть - непрерываемыми. Заданы характеристики заданий: время готовности, директивный срок и длительность выполнения, которая зависит от объема выделенного ресурса. Решается задача суще-ствования допустимого расписания в зависимости от директивных сроков и суммарного объема ресурса.

The problem of scheduling in the multiprocessor computing system for a case when a part of jobs al-lows interruptions and switches from one processor to another, and a part does not allow is considered. Jobs are char-acterized by duration and a directive interval. Besides processors, in the system there is an additional not renewable resource, and duration of execution of each work linearly depends on quantity of this resource allocated to it. The minimum values of an additional resource and directive term at which there is an feasible schedule are defined.
К вопросу оперативного контроля качества масличных семян
Authors: А.Н. Лисицын , В.Н. Марков , В.Н. Григорьева , Т.П. Аюкова , И.В. Довгалюк , И.А. Лисицына
Published: November 2024

Качество масличных семян играет важную, если не главную роль в получении качественных масел пищевого направления. Существующие нормативные документы на семена, как сырье, либо не в полной мере отражают все вопросы качества, либо делают упор на показатели безопасности. Существует необходимость в быстротечном оперативном контроле качества семян. В работе представлена попытка создания универсального показателя для такого контроля.

The quality of oilseeds plays an important, if not the main, role in obtaining high-quality edible oil. Existing regulations on seeds as raw materials either do not fully reflect all quality issues, or emphasize safety indicators. There is a need for fleeting operational quality control of seeds. The paper presents an attempt to create a universal indicator for such control.
Оценка качества кормовой продукции масложировой промышленности по степени окисленности
Authors: Н.Н. Фролова , Е.Б. Скоморохова , Т.А. Матвеева
Published: November 2024

Качество кормов в значительной степени зависит от входящих в их состав липидов, которые подвержены гидролитическому расщеплению и окислению. Перекиси и гидроперекиси, являющиеся продуктами окисления липидов, токсичны и могут приводить к возникновению патологических изменений в организме животных. Существенное влияние на качество кормов оказывают не только первичные, но и вторичные продукты окисления входящих в их состав липидов (оксикислоты, альдегиды и др.). Проблема степени окисленности кормов на сегодняшний день недооценена. Определение содержания первичных и вторичных продуктов окисления и продуктов гидролиза липидов, входящих в состав кормовой продукции масложировой промышленности (жмыхи, шроты), позволяет объективно оценить ее качество по степени окисленности, установить наиболее приемлемые значения кислотного и перекисного чисел и рекомендовать их для утверждения на законодательном уровне, как единственно верные значения ПДУ кислотного и перекисного чисел на современном этапе развития технологии маслодобывания и кормопроизводства.

The quality of feed largely depends on their constituent lipids, which are subject to hydrolytic cleavage and oxidation. Peroxides and hydroperoxides, which are products of lipid oxidation are toxic and can lead to patho logical changes in the body of animals. Not only primary, but also secondary oxidation products of lipids (oxy-acids, aldehydes, etc.) have a significant impact on the quality of feed. The problem of the degree of oxidization of feed today underestimated. The determination of primary and secondary lipid oxidation products and lipid hydrolysis products included in the feed production oil and fat industry allows to objectively assess its quality by the degree of oxidation, determine the most appropriate values of the acid and peroxide value and recommend them for approval at the legislative level, as the only true values of the maximum permissible level of the acid and peroxide value at the present stage of technology development oil production and fodder production.