bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Literatur: Sistem Informasi Manajemen Rumah Sakit
Authors: Sitompul Iin Sri Derfi
Published: August 2023

Saat ini, perkembangan dan kemajuan teknologi informasi semakin berkembang pesat. Agar suatu instansi/perusahaan dapat menggunakan informasi sebagai dasar pengelolaan dan pengolahan data, diperlukan sistem aplikasi di berbagai bidang (Deddy, 2016). Penggunaan sistem informasi di rumah sakit (SIMRS) sangat penting untuk mencapai pelayanan yang berkualitas. Namun perlu dilakukan monitoring dan evaluasi untuk mengetahui manfaat SIMRS di unit kerja rumah sakit. Dengan demikian, rumah sakit dapat mengembangkan SIMRS dengan mempertimbangkan faktor-faktor yang mempengaruhi penggunaan dan kegunaan SIMRS. Tujuan kajian literatur ini adalah untuk mengidentifikasi faktor-faktor yang memandu dan menghambat penerapan sistem informasi manajemen informasi. Metode yang digunakan adalah metode database elektronik yang menggunakan Google Scholar untuk pencarian jurnal dengan istilah pencarian “Sistem informasi manajemen di rumah sakit”. Sebanyak 20.600 jurnal tersedia, namun hanya 10 yang memenuhi kriteria. Hasil kajian mengidentifikasi tiga penyebab utama: prosedur operasi standar (SPO) dan integritas manajemen, pemahaman dan keterampilan SDM, sistem dan teknologi. Kata Kunci: Faktor Penghambat, implementasi, SIMRS, standar prosedur operasionalToday the development and progress of information technology is growing rapidly. Application systems in various fields are a must for an agency / company to utilize information as a basis for administration and data processing (Deddy, 2016). The implementation of an information system in hospitals (SIMRS) is very important to achieve quality services. However, it is necessary to monitor and evaluate to find out how the benefits of SIMRS in the hospital work unit. Thus, it allows the hospital to develop SIMRS taking into account the factors that influence and benefit the use of SIMRS. The purpose of this literature review is to determine the driving and inhibiting factors in the implementation of Information Management Information Systems. The method used is the electronic data base method, the search for journals using google schoolar with the keyword "management information systems in hospitals", totaling 20,600 journals but only using 10 journals that match the criteria. The results of the study identified three main root causes, namely the completeness of standard operational procedures (SOP) and management, human resource capabilities, systems and technologKeyword: Inhibiting factors, implementation, SIMRS, standard operating procedures.
Perspectivas sobre el neoliberalismo: un estado de la cuestión
Authors: Fair Hernán
Published: August 2023

Este trabajo se propone contribuir al desarrollo de un estado general de la cuestión en torno al neoliberalismo para la investigación social. Para ello, revisa y sistematiza las principales definiciones, caracterizaciones y perspectivas teóricas sobre el neoliberalismo. Como resultado del análisis bibliográfico, se detectaron cinco perspectivas en torno al neoliberalismo. Por último, se propuso una conceptualización integradora del neoliberalismo, desde un enfoque posfundacional y posmarxista.
Gambaran Pengetahuan Dan Sikap Masyarakat Tentang Mitigasi Dan Kesiapsiagaan Bencana Banjir
Authors: Istiqomah Yulaikha , Prajayanti Eska Dwi
Published: August 2023

Masyarakat di tepi sungai sangat rentan terhadap banjir, sehingga sangat penting untuk memahami mitigasi dan kesiapsiagaan bencana banjir untuk menghadapi dan mengantisipasi banjir. Tujuan penelitian mengetahui gambaran pengetahuan dan sikap masyarakat tentang mitigasi dan kesiapsiagaan bencana banjir. Metode penelitian deskriptif kuantitatif, teknik pengambilan data purposive sampling, Populasi penelitian ini adalah warga RW 5,6,7 Kelurahan Bumi Laweyan  sebanyak 478 kepala keluarga, sampel 72 responden, instrument penelitian menggunakan kuesioner pengetahuan mitigasi, pengetahuan kesiapsiagaan, sikap mitigasi dan sikap kesiapsiagaan bencana banjir yang telah diuji validitas dan reliabilitas oleh peneliti. Hasil penelitian menunjukkan dari 72 responden di Kelurahan Bumi Kecamatan Laweyan gambaran pengetahuan mitigasinya 87,5% dalam kategori baik, 11,1% dalam kategori cukup dan 1,4% dalam kategori kurang dan gambaran sikap mitigasinya 98,6% positif dan 1,4% negatif. Gambaran pengetahuan kesiapsiagaannya 87,5% dalam kategori baik, 8,3% dalam kategori cukup dan 4,2% dalam kategori kurang dan sikap kesiapsiagaannya 98,6% positif dan 1,4% negatif. Sebagian besar masyarakat memiliki pengetahuan yang baik dan sikap positif tentang mitigasi bencana banjir. Bagi peneliti selanjutnya diharapkan melakukan penelitian mengeksplorasi menggunakan metodologi hipotetis dan prosedur yang berbeda dan mengecek pengaruh dari masing- masing variabel, untuk mengetahui pengaruh terhadap mitigasi dan kesiapsiagaan bencana banjir dan melaksanakan penelitian yang menjadi kekurangan dari tinjauan ini.
Efektivitas Relaksasi Benson Terhadap Intensitas Nyeri Dan Pemberian ASI Eksklusif Pada Ibu Pasca Seksio Sesarea: Studi Eksperimental Quasy
Authors: Hartati Suryani , Ayuningtyas Fajar Listya , Kherunnisa Kherunnisa , Arnils Gustika , Chipojola Roselyn , Ma’rifah Atun Roudatul , Rahman Muhammad Fauzi , Tabara Sri Agustin , Huda Mega Hasanul
Published: August 2023

Operasi sesarea merupakan metode persalinan yang banyak dipilih saat ini. Hal ini menyebabkan nyeri dan mempengaruhi jumlah prolaktin darah serta motivasi ibu untuk menyusui bayinya. Oleh karena itu diperlukan penanganan nyeri pasca persalinan agar proses menyusui dapat berjalan dengan optimal. Relaksasi Benson merupakan terapi komplementer yang dapat dilakukan untuk mengurangi nyeri. Tujuan Penelitian ini adalah untuk mengetahui pengaruh teknik relaksasi Benson terhadap intensitas nyeri dan menyusui pada ibu post seksio sesaria di Rumah Sakit Hermina. Metode: Penelitian ini menggunakan desain quasy eksperiment yang dibagi menjadi dua kelompok yaitu kelompok intervensi dan kontrol, jumlah responden sebanyak 80. Penelitian dilakukan di Rumah Sakit  Hermina pada bulan Oktober-Januari 2022. Uji statistik yang digunakan dalam penelitian ini adalah Mann -Whitney. Hasil penelitian ini rata-rata intensitas nyeri pada kelompok intervensi setelah penerapan teknik relaksasi Benson adalah 2,03(0.791) dan pada kelompok kontrol 3,95(0.832) dengan P Value = 0.000,  sedangkan distribusi pemberian ASI eksklusif P Value=0,31 tidak memiliki perbedaan yang significan. Intervensi relaksasi Benson diharapkan dapat digunakan sebagai bahan pertimbangan dalam mengembangkan metode  nonfarmakologi komplementer untuk menurunkan intensitas nyeri pada pasien post seksio sesarea yang dirawat di rumah sakit.
Association of Zingiber Aromaticum Vaal. With Zerumbone and Its Biological Activity : A Literature Review
Authors: Murwanti Retno , Pratiwi Rima Dwi , Gani Andayana Puspitasari
Published: August 2023

The main objective of this article is to explore the available classified information on Zingiber aromaticum Val. Rhizome and its active compound, Zerumbone. Throughout history, this plant has been utilized to treat various ailments such as abdominal disorders, cough, anemia, malaria, jaundice, arthritis, and infections. Recently, Zerumbone, a sesquiterpene compound found in the rhizomes, has gained attention for its biological activity. This article reviews the current research on the pharmacological activities of Z. aromaticum Val. Rhizome, with a specific focus on its active component, Zerumbone.This review found that the antioxidant and antiinflammatory effects of Zerumbone play a role in the pharmacological effects exhibited by Z. aromaticum, such as antidiabetic, antiparasitic, anti-hyperlipidemia, antianxiety, and antiaging effects. Additionally, the correlation between the biological activity of Zerumbone and the pharmacological activity of Z. aromaticum extract is discussed. This review provides a valuable reference for developing and further researching Zingiber aromaticum Val. and Zerumbone in medical treatments.
Determinants of Active Aging Affect Healthy Life Expectation
Authors: Theresa Ria Maria Theresa , Dewiastuti Marlina , Kristanti Melly , Cantika
Published: August 2023

Life expectancy is an indicator of successful health development. It is estimated the elderly population will increase along with the increase in life expectancy, in 2050 there will be an increase 3 times in the number of elderly from 2013. The increase in the number of elderly raises a health sector complicated problem. The elderly group will experience a decrease in health status either naturally or due to illness. Goals of the health program focus on life expectancy. West Java is the largest proportion with  Indramayu a city in West Java that has a target life expectancy that reaches the target. The government's efforts to improve the elderly welfare are realized in various programs so that an increase in the elderly population does not increase health problems.  Indicators of elderly health can be measured by active aging (AA).. The determinants of the AA component, which include health and well-being, are indicators for assessing healthy life expectancy in the elderly. Assessment of healthy life expectancy is assessed from several determinants. Assessment of healthy life expectancy can determine health development targets, especially in the elderly. This study associated dietary patterns and smoking habits with increased healthy life expectancy.
Correlation Between Health Worker's Support and Coping Strategy to Mother's Resilience Level in Managing Annual Flood in the COVID-19 Pandemic
Authors: Setiya Dewi Yulis , Qona'ah Arina , Alfaruq Fikri
Published: August 2023

Low coping strategies and health worker factors reduce the ability to survive from flood. This can lead to low mother’s resilience. This study aims to analyze the correlation between health worker factors and coping strategy against mother’s resilience in managing the impact of annual flood disasters during the COVID-19 pandemic. This research used correlational analytic method with cross sectional approach. This study used a sample of 121 mothers in Sukorejo Village, Karangbinangun District, Lamongan Regency who were affected by flood. The research instrument used a questionnaire of support, facilities, and motivation health workers;copingstrategy; and mother’s resilience. Spearman Rho Analysis correlation test was used as analytic approach with a significance of <0.05. The data obtained analyzed using a Spearman Rho correlation test. There was a correlation between health worker factors and mother’s resilience (p=0.003: r=0.264).  In addition, there was a correlation between coping strategies and mother’s resilience (p=0.000: r=0.369). The higher health workers factor and mother’s coping strategies level, the higher mother’s resilience managing the flood impact. Capacity building for health workers is needed to be able to educate mothers about flood impact management, so that ultimately improve their coping strategies.
Severe Dengue or Covid-19 Related MIS-C? Diagnostic Challenges in Resource-Limited and Dengue-Endemic Regions
Authors: Angelina  , Dewi Arfianti Chandra
Published: August 2023

Besides serological cross-reactivity and co-infection between dengue and SARS-CoV-2, diagnostic challenges arise because many people have had positive dengue IgG in dengue-endemic regions, and patients usually come after 4-5 days of fever. We report a case of 9-year-old girl, diagnosed with dengue with warning signs on admission because of fever, severe abdominal pain, thrombocytopenia, and positive dengue IgG. The subsequent course of the illness was not consistent with dengue infection because the shock happened during the febrile phase concurrent with rising leucocyte and platelet counts, the fever continued for longer than seven days, and there was bilateral non-purulent conjunctivitis with subconjunctival hemorrhage. She was diagnosed with MIS-C because of positive SARS-CoV-2 IgG and hyperinflammatory markers. Her clinical condition improved progressively after steroid administration. Clinical awareness about MIS-C is required to avoid misdiagnosis and improper treatment during or after the COVID-19 pandemic. Every clinician should consider MIS-C as a differential diagnosis if patients have inconsistencies with the course of dengue illness.
Using predator diets to infer forage fish distribution and assess responses to climate variability in the eastern Bering Sea
Authors: Gunther KM , Baker MR , Aydin KY
Published: August 2023

Forage fishes comprise an integral part of marine food webs in the highly productive ecosystems of the North Pacific. However, significant knowledge gaps exist related to the status of forage fish, their life histories, and how populations may react to future climatic shifts. Standardized bottom trawl surveys are critical to the stock assessment of groundfish but lack the gear and protocols to quantitatively evaluate small pelagic forage fish. Where diet data are available, predators may be used as an indirect method of collecting data on forage fish distribution and relative abundance. We used stomach contents data to infer predator-prey interactions in the eastern Bering Sea and to analyze the distribution of 5 forage taxa over a 34 yr time series (1985-2019). Using 4 dominant groundfish predators, we constructed forage fish and predator depth and temperature habitat profiles and used center of gravity (COG) analysis and global index of collocation to examine predator-prey overlap. Results provide insight on the habitat partitioning and competitive interactions between forage species and the dynamics between predators and prey. Interannual COG analyses indicated recent periods of cooling (2007-2013) and warming (2014-2019) had significant effects on the distribution of forage fish, and suggest differences in the relative resilience of forage fish populations to climate change in this region. Population shifts were particularly evident in recent periods of anomalous warming, highlighting the need to understand how future periods of prolonged warming may affect predator-prey dynamics. Results also demonstrate the importance of predator diet time series and how these data might inform multi-species models and management strategies.
Analysis of Social Network and Performance of High-Income Artists
Authors:   The Korean Society of Culture and Convergence, Jee Sangbaum , Ahn Sungah
Published: August 2023

This study is the first research to derive a social network activity index based on the career factors of the top 50 artists and analyze its relationship with transaction performance. The analysis results indicate that personal network centrality among artists has the most significant impact on transaction performance, followed by the importance of group network centrality. Additionally, the study categorizes artists into three clusters based on their careers: major and awards, education and number of solo exhibitions, and whether they studied abroad and social experience. These clusters demonstrate differences in transaction performance and social network characteristics. This study validates the importance of social networks that influence the transaction performance of visual artists, particularly by examining the network characteristics more closely by distinguishing between individual networks among artists and organization networks involving artists.
Stuart Hall’s Cinematic Collaboration and Visualization of Theory: Focusing on Isaac Julien's
Authors:   The Korean Society of Culture and Convergence, Jeon Solbee , Lee Harim
Published: August 2023

This study examines the implications of the work in which theoretical thinking is visualized, realized, and embodied through art, focusing on the case of cinematic collaboration between cultural researchers and artists. To this end, the film  by British black artist Isaac Julien is compared and analyzed with the theoretical thinking of cultural researcher Stuart Hall. Stuart Hall has interacted with black artists since the 1980s, especially in the cinematic collaboration of Isaac Julien, who has shared a sense of the problem of “visualization of theory,” in his research on representation, race, and identity. Stuart Hall's thinking, which emphasized the politics of identification that moves in the characteristics of difference, self-reflection, and context dependence, is reproduced in this film around sight and boundaries. Through this, it can be confirmed that theoretical concepts that change according to history and context find a place to talk in the area of representation.
Analysis of Cultural Experiences before and after COVID-19 among University Students in Gyeongsangnam-do
Authors:   The Korean Society of Culture and Convergence, Jung SeongA , Lee Byunghoon
Published: August 2023

This study analyzed the degree of impact on the cultural experience of college students before and after COVID-19 and the degree of change in the scope of cultural experience using essays written by college students in Gyeongnam. The purpose of this is to suggest the direction of cultural content development that can be prepared for college students in their 20s in Gyeongnam. As a research method, the text mining method was used as an analysis to extract meaningful keywords related to cultural experiences from essays submitted by students. This study was conducted in Gyeongsangnam-do, and through this, it is to discuss the establishment of a direction for regional cultural development that reflects the actual needs and needs of college students in their 20s living in Gyeongsangnam-do. As a result of the study, first, it is to expand from indoor culture to outdoor culture. Second, it is to expand from offline cultural activities to online cultural activities. Third, it is to strengthen regional-centered cultural life.
A Study on the Influence of Chinese Women's Psychological Security on Self-Clothing Image, Image Congruence, and Appearance Orientation
Authors:   The Korean Society of Culture and Convergence, Hong Ye
Published: August 2023

This research is aimed at explore the Chinese women's psychological security under the influence of self-clothing image, image congruence and appearance orientation. A regression analysis of 272 Chinese women found that, first, all sub-factors of psychological security have a positive impact on their self-clothing image, image congruence and appearance orientation except for self-discipline. Second, self-clothing image had a positive influence on image consistency and appearance orientation, while image consistency had a positive effect on appearance orientation. This research upon these factors, not only contribute to a theoretical basis for understanding the types of women's psychological security, but the conclusion has marketing information and practical significance for clothing enterprises
A Case Study of Family Therapy on the Factors that Cause Change and Hormonal Changes in a Middle-Aged Couple Experiencing Marital Conflict in Their 50s: KBS 1tv Mysteries of the Human Body
Authors:   The Korean Society of Culture and Convergence, Jun Jooram
Published: August 2023

This study is a case study of a middle-aged couple experiencing marital conflict in their 50s, focusing on the factors that cause changes and hormonal changes that occurred during the counseling process. The counseling session focuses on understanding the family structure based on Minuchin's structural family therapy theory, and uses Satir's communication technique to diagnose problems in the couple's communication method and to provide a more positive In order to change the direction, 10 sessions of counseling were conducted, focusing on the emotional exchange of the severed marital relationship. As a result, first, the factors that cause changes in couples evaluated by the counselor are a strong will to restore the marital relationship, recognition of personality differences and an accepting attitude towards the partner, self- responsibility for the causes of conflict in the marital relationship, and dysfunctional communication style. Cognition and active change attempts were identified as four factors. Second, as a result of the couple's blood tests before and after counseling, cortisol decreased and serotonin and oxytocin increased, proving that hormonal changes were positively changed through the couple counseling process. Based on these findings, we discussed suggestions for follow-up research and suggestions at the consulting site.
The Media Transition Pattern and Meaning of Webtoon Based on Classical Literature from the Perspective of Coexistence: Focusing on the Webtoon  and
Authors:   The Korean Society of Culture and Convergence, Jo Leera
Published: August 2023

This study aims to analyze the webtoons  and  to examine the media transition pattern and meaning from the perspective of ‘coexistence’. Both works depict aspects of the coexistence of human and dehuman beings. This description can convey the value and necessity of coexistence in moving toward the post-human era. In addition, it is expected to be a more resonant delivery method as it uses the classical literature, which implies Korea's own perception. Like this media transformation will enable classical literature to revive in the modern world and maintain its own vitality and values, while also using classical literature works to create modern contents that contains Korea's unique meanings and values.
A Study on the Training Methods for Strengthening the Presence of Actors through Traditional Asian Performing and Martial Arts: Focusing on the Barba, Zarrilli
Authors:   The Korean Society of Culture and Convergence, Hwang Seokha
Published: August 2023

The purpose of this paper is to examine the training methods used by Western directors influenced by traditional Asian performing and martial arts to strengthen the presence of actors. Despite the differences in the ways the Barba and Zarrilli encountered, experienced and applied traditional Asian performing and martial arts, their view of ‘actor training’ is relatively similar. The directors remind us of the importance of training - the process of ‘self-definition’ - through which the actor corrects his/her wrong perception caused by the lack of control of the body. The training that strengthens the presence of an actor should be an ‘non-daily’ training as well as ‘psychophysical’ wherein the mind and body are organically integrated. The actor needs training that enables breathing to be organically integrated with ‘ki-energy’ rooted in the danjeon area and that encourages the development of the ‘dilated body’ through the actor’s projection of his/her energy enabled by his/her spatial ‘sensory awareness’.
Strategic imperatives of functioning of public sector banks in the post-war stage
Authors:   SESE “The Academy of Financial Management”, LYUBICH Oleksandr , OLIINYK Dmytro ,   SESE “The Academy of Financial Management”
Published: August 2023

Introduction. The issue of the role of state-owned banks in modern conditions is attracting more and more attention. In Ukraine, the share of the state-owned banks segment makes up more than half of the banking services market. Accordingly, the synthesis of existing experience and the development of approaches to the use of the potential of state banks in the interests of supporting the development of the economy in crisis conditions is an urgent scientific task for Ukraine. Problem Statement. The role and place of state banks in ensuring economic development in conditions of exogenous challenges. Purpose. To determine the peculiarities of the work of banks with state participation in the capital in Ukraine and to provide recommendations for increasing the efficiency of using their potential in war conditions and at the stage of post-war economic recovery. Methods. The work uses the methods of theoretical generalization, systematic, comparative and economic analysis, systematization, logical generalization, analytical presentation, and synthesis. Results. In accordance with foreign experience, it has been confirmed that in the conditions of wartime challenges, state banks play an important stabilizing role in ensuring the stability of the financial market. During the war, Ukrainian state banks were able not only to ensure uninterrupted provision of financial services and payment and settlement operations, but also to support the implementation of state credit programs. The segment of state banks plays an important role in the financial support of the state's fiscal policy. Such a role of state-owned banks in Ukraine will most likely remain at the stage of post-war economic recovery. Conclusions. In accordance with the acquired advantages and experience of pre-war activities, the forces of state banking institutions should be concentrated in the key areas of supporting the functioning of the economy in wartime conditions within the framework of defined state policy tasks. At the same time, the strategy of their activities needs to be adjusted with increased specialization in accordance with the strategic directions of economic recovery.
Assessment of conformity of measures of the financial monitoring system of Ukraine with FATF international standards
Authors:   SESE “The Academy of Financial Management”, KUZMINSKA Olga
Published: August 2023

Introduction. The list of priority European integration measures in Ukraine envisages further harmonization of the national financial monitoring system with FATF international standards (recommendations). Therefore, it is important to analyze both the results of the assessment of the technical compliance of measures in the anti-legalization sphere of Ukraine with FATF recommendations, and their effectiveness. Problem Statement. Assessment of the degree of technical compliance of the prevention and countermeasures system in Ukraine with the FATF recommendations, and generalization of the results of the assessment of the compliance of the measures of the national financial monitoring system with the performance criteria presented in the MONEYVAL reports. Purpose. To systematize strong and weak characteristics of the technical compliance of measures of the national financial monitoring system with FATF recommendations, to investigate the compliance of the current practice of financial intelligence of Ukraine with the MONEYVAL efficiency criteria, as well as to conduct a comparative analysis of international experience in the anti-legalization field on the basis of assessment of the technical compliance of measures in the anti-legalization field with FATF international standards (recommendations) and the result characteristics of the effectiveness of these measures presented in the MONEYVAL reports. Methods. General scientific and special methods based on the dialectical approach are applied: induction, deduction, analysis, synthesis, grouping, comparison. Results. The article provides a comparative analysis of MONEYVAL reports on the technical compliance of measures of anti-legalization systems with FATF international standards in Ukraine, Lithuania, Poland, Cyprus, Albania, and Bulgaria, analyzes the compliance of measures of prevention and countermeasures systems of these countries with the efficiency criteria specified in MONEYVAL reports. MONEYVAL reporting information has been systematized according to the levels of assessments of technical compliance with FATF international standards of measures of prevention and countermeasures of the specified countries, and the levels of compliance with performance criteria in these countries. Conclusions. The results of the research can be used in the further harmonization with FATF international standards of national regulatory and legal acts, the organization of international cooperation and the exchange of experience between national financial intelligence services.
Application of piezoelectric materials in the field of bone: a bibliometric analysis
Authors: Zhang Yu-Qin , Geng Qian , Li Chao , Wang Hai-Cheng , Ren Chuan , Zhang Yi-Fan , Bai Jun-Sheng , Pan Hao-Bo , Cui Xu , Yao Meng-Xuan , Chen Wei
Published: August 2023

In the past 4 decades, many articles have reported on the effects of the piezoelectric effect on bone formation and the research progress of piezoelectric biomaterials in orthopedics. The purpose of this study is to comprehensively evaluate all existing research and latest developments in the field of bone piezoelectricity, and to explore potential research directions in this area. To assess the overall trend in this field over the past 40 years, this study comprehensively collected literature reviews in this field using a literature retrieval program, applied bibliometric methods and visual analysis using CiteSpace and R language, and identified and investigated publications based on publication year (1984–2022), type of literature, language, country, institution, author, journal, keywords, and citation counts. The results show that the most productive countries in this field are China, the United States, and Italy. The journal with the most publications in the field of bone piezoelectricity is the International Journal of Oral & Maxillofacial Implants, followed by Implant Dentistry. The most productive authors are Lanceros-Méndez S, followed by Sohn D.S. Further research on the results obtained leads to the conclusion that the research direction of this field mainly includes piezoelectric surgery, piezoelectric bone tissue engineering scaffold, manufacturing artificial cochleae for hearing loss patients, among which the piezoelectric bone tissue engineering scaffold is the main research direction in this field. The piezoelectric materials involved in this direction mainly include polyhydroxybutyrate valerate, PVDF, and BaTiO3.
Field experiences for pre-service teachers post-COVID-19: structures required to support mental health
Authors: Adams Megan , Rodriguez Sanjuana , Ramirez Karla , Jackson Virginie , Garefino Allison
Published: August 2023

This study investigates a supplemental field experience taking place on a university campus in the summer of 2021. The program includes linguistically, culturally, and socioeconomically marginalized children performing below grade level in reading. Pre-service teachers (PSTs) work with the children for 4 weeks, focusing on science-based literacy instruction. The initial findings of this case study were that lesson planning, teacher dispositions, and willingness to accept feedback are critical for PSTs. Additionally, a major concern in the findings is the increased evidence of mental health concerns for the children and PSTs. The findings indicate a need for focused training on social–emotional learning with special care relating to stressors caused by COVID-19. There must also be additional training for PSTs on explicit and detailed lesson plans, adjusting their dispositions, and science-based literacy instruction taught in literacy blocks.
Early assessment of effects of dam removal on abiotic fluxes of the Selune River, France
Authors: Fovet Ophelie , Meric François , Crave Alain , Cador Jean-Michel , Rollet Anne-Julia
Published: August 2023

The Water Framework Directive set for European Union countries the objective of restoring the ecological and/or sediment continuity of rivers, as the latter is relevant for providing suitable habitats for the former. Indeed, abiotic fluxes and variables shape riverine ecological habitats and are likely to be modified by barriers such as dams. Two dams were removed from the Selune River (northwestern France) from spring 2017 to summer 2022. The objective of this study was to describe and quantify how the dams modified abiotic parameters and fluxes, as well as the dynamics of these fluxes during dam removal. We monitored coarse and fine sediments, water temperature and nutrient concentrations in the Selune River from upstream to downstream of the dams from 2015 to 2023. The results showed that coarse sediments of the riverbed are a legacy and that current hydrodynamic conditions are not sufficient to move them much, with or without the dams. In addition, it appears that at this early stage after the removal some downstream parameters, especially nutrient concentrations and water temperature, have already converged towards upstream signals, while fine sediment stored in the dam’s reservoirs are still destocking. Restoring ecological continuity of the Selune River will involve dynamics of abiotic parameters over longer time scales, in response to removal of the dams, and over larger spatial scales, in response to climate and other global changes.
Variation in the fibroblast growth factor 23 (FGF23) gene associates with serum FGF23 and bone strength in infants
Authors: Enlund-Cerullo Maria , Holmlund-Suila Elisa , Valkama Saara , Hauta-alus Helena , Rosendahl Jenni , Andersson Sture , Pekkinen Minna , Mäkitie Outi
Published: August 2023

Introduction: The effects of genetic variation in fibroblast growth factor 23 (FGF23) are unclear. This study explores the associations of single-nucleotide polymorphisms (SNPs) of FGF23 with phosphate and vitamin D metabolism and bone strength in early childhood.

Methods: The study is part of the vitamin D intervention in infant (VIDI) trial (2013–2016), in which healthy term infants born to mothers of Northern European origin received vitamin D3 supplementation of 10 or 30 μg/day from 2 weeks to 24 months of age (ClinicalTrials.gov NCT01723852). Intact and C-terminal FGF23 (cFGF23), 25-hydroxyvitamin D (25-OHD), parathyroid hormone, phosphate, and peripheral quantitative computed tomography (pQCT)-derived bone strength parameters were analyzed at 12 and 24 months. The study included 622 VIDI participants with genotyping data on FGF23 SNPs rs7955866, rs11063112, and rs13312770.

Results: Rs7955866 minor allele homozygotes had lowest cFGF23 at both time-points (mixed model for repeated measurements, pvariant = 0.009). Minor alleles of rs11063112 were associated with a greater age-related decrease in phosphate concentration (pinteraction = 0.038) from 12 to 24 months. Heterozygotes of rs13312770 had the greatest total bone mineral content (total BMC), cross-sectional area (total CSA), and polar moment of inertia (PMI) at 24 months (ANOVA p = 0.005, 0.037, and 0.036, respectively). Rs13312770 minor alleles were associated with a greater increase of total BMC, but a smaller increase of total CSA and PMI, during follow-up (pinteraction <0.001, 0.043, and 0.012, respectively). Genotype of FGF23 did not modify 25-OHD.

Conclusion: The study finds that genetic variation in FGF23 modifies cFGF23, phosphate, and pQCT-derived bone strength parameters from 12 to 24 months of age. These findings potentially promote an understanding of the regulation of FGF23 and its role in bone metabolism and temporal changes thereof during early childhood.
Bacteria-based immunotherapy for cancer: a systematic review of preclinical studies
Authors: Zhou Min , Tang Yucheng , Xu Wenjie , Hao Xinyan , Li Yongjiang , Huang Si , Xiang Daxiong , Wu Junyong
Published: August 2023

Immunotherapy has been emerging as a powerful strategy for cancer management. Recently, accumulating evidence has demonstrated that bacteria-based immunotherapy including naive bacteria, bacterial components, and bacterial derivatives, can modulate immune response via various cellular and molecular pathways. The key mechanisms of bacterial antitumor immunity include inducing immune cells to kill tumor cells directly or reverse the immunosuppressive microenvironment. Currently, bacterial antigens synthesized as vaccine candidates by bioengineering technology are novel antitumor immunotherapy. Especially the combination therapy of bacterial vaccine with conventional therapies may further achieve enhanced therapeutic benefits against cancers. However, the clinical translation of bacteria-based immunotherapy is limited for biosafety concerns and non-uniform production standards. In this review, we aim to summarize immunotherapy strategies based on advanced bacterial therapeutics and discuss their potential for cancer management, we will also propose approaches for optimizing bacteria-based immunotherapy for facilitating clinical translation.
The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population
Authors: Medina Tiago S. , Murison Alex , Smith Michelle , Kinker Gabriela S. , Chakravarthy Ankur , Vitiello Glauco A. F. , Turpin Williams , Shen Shu Yi , Yau Helen L. , Sarmento Olga F. , Faubion William , Lupien Mathieu , Silverberg Mark S. , Arrowsmith Cheryl H. , De Carvalho Daniel D.
Published: August 2023

Introduction

The imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by dynamic changes to the chromatin that facilitate or repress gene expression.

Methods

Here, we characterized the chromatin landscape and heterogeneity of intestinal and peripheral CD4 T cellsfrom IBD patients using in house ATAC-Seq and single cell RNA-Seq libraries.

Results

We show that chromatin accessibility profiles of CD4 T cells from inflamed intestinal biopsies relate to genes associated with a network of inflammatory processes. After integrating the chromatin profiles of tissue-derived CD4 T cells and in-vitro polarized CD4 T cell subpopulations, we found that the chromatin accessibility changes of CD4 T cells were associated with a higher predominance of pathogenic Th17 cells (pTh17 cells) in inflamed biopsies. In addition, IBD risk loci in CD4 T cells were colocalized with accessible chromatin changes near pTh17-related genes, as shown in intronic STAT3 and IL23R regions enriched in areas of active intestinal inflammation. Moreover, single cell RNA-Seq analysis revealed a population of pTh17 cells that co-expresses Th1 and cytotoxic transcriptional programs associated with IBD severity.

Discussion

Altogether, we show that cytotoxic pTh17 cells were specifically associated with IBD genetic variants and linked to intestinal inflammation of IBD patients.
Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018
Authors: Cheng Wenke , Bu Xiancong , Xu Chunhua , Wen Grace , Kong Fanliang , Pan Huachun , Yang Shumin , Chen Siwei
Published: August 2023

Background

Significant evidence suggests that asthma might originate from low-grade systemic inflammation. Previous studies have established a positive association between the systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI) levels and the risk of stroke. However, it remains unclear whether SII, SIRI and the prevalence of stroke are related in individuals with asthma.

Methods

The present cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. SII was calculated using the following formula: (platelet count × neutrophil count)/lymphocyte count. SIRI was calculated using the following formula: (neutrophil count × monocyte count)/lymphocyte count. The Spearman rank correlation coefficient was used to determine any correlation between SII, SIRI, and the baseline characteristics. Survey-weighted logistic regression was employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to determine the association between SII, SIRI, and stroke prevalence. The predictive value of SII and SIRI for stroke prevalence was assessed through receiver operating characteristic (ROC) curve analysis, with the area under the ROC curve (AUC) being indicative of its predictive value. Additionally, clinical models including SIRI, coronary heart disease, hypertension, age, and poverty income ratio were constructed to evaluate their clinical applicability.

Results

Between 1999 and 2018, 5,907 NHANES participants with asthma were identified, of which 199 participants experienced a stroke, while the remaining 5,708 participants had not. Spearman rank correlation analysis indicated that neither SII nor SIRI levels exhibited any significant correlation with the baseline characteristics of the participants (r<0.1). ROC curves were used to determine the optimal cut-off values for SII and SIRI levels to classify participants into low- and high-level groups. Higher SII and SIRI levels were associated with a higher prevalence of stroke, with ORs of 1.80 (95% CI, 1.18-2.76) and 2.23 (95% CI, 1.39-3.57), respectively. The predictive value of SIRI (AUC=0.618) for stroke prevalence was superior to that of SII (AUC=0.552). Furthermore, the clinical model demonstrated good predictive value (AUC=0.825), with a sensitivity of 67.1% and specificity of 87.7%.

Conclusion

In asthmatics, higher levels of SII and SIRI significantly increased the prevalence of stroke, with its association being more pronounced in individuals with coexisting obesity and hyperlipidaemia. SII and SIRI are relatively stable novel inflammatory markers in the asthmatic population, with SIRI having a better predictive value for stroke prevalence than SII.
An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection
Authors: de Brito Rory C. F. , Holtham Kerry , Roser Jessica , Saunders Jack E. , Wezel Yvonne , Henderson Summer , Mauch Thekla , Sanz-Bernardo Beatriz , Frossard Jean-Pierre , Bernard Matthieu , Lean Fabian Z. X. , Nunez Alejandro , Gubbins Simon , Suárez Nicolás M. , Davison Andrew J. , Francis Michael J. , Huether Michael , Benchaoui Hafid , Salt Jeremy , Fowler Veronica L. , Jarvis Michael A. , Graham Simon P.
Published: August 2023

Porcine reproductive and respiratory syndrome virus (PRRSV) remains a leading cause of economic loss in pig farming worldwide. Existing commercial vaccines, all based on modified live or inactivated PRRSV, fail to provide effective immunity against the highly diverse circulating strains of both PRRSV-1 and PRRSV-2. Therefore, there is an urgent need to develop more effective and broadly active PRRSV vaccines. In the absence of neutralizing antibodies, T cells are thought to play a central role in controlling PRRSV infection. Herpesvirus-based vectors are novel vaccine platforms capable of inducing high levels of T cells against encoded heterologous antigens. Therefore, the aim of this study was to assess the immunogenicity and efficacy of an attenuated herpesvirus-based vector (bovine herpesvirus-4; BoHV-4) expressing a fusion protein comprising two well-characterized PRRSV-1 T-cell antigens (M and NSP5). Prime-boost immunization of pigs with BoHV-4 expressing the M and NSP5 fusion protein (vector designated BoHV-4-M-NSP5) induced strong IFN-γ responses, as assessed by ELISpot assays of peripheral blood mononuclear cells (PBMC) stimulated with a pool of peptides representing PRRSV-1 M and NSP5. The responses were closely mirrored by spontaneous IFN-γ release from unstimulated cells, albeit at lower levels. A lower frequency of M and NSP5 specific IFN-γ responding cells was induced following a single dose of BoHV-4-M-NSP5 vector. Restimulation using M and NSP5 peptides from PRRSV-2 demonstrated a high level of cross-reactivity. Vaccination with BoHV-4-M-NSP5 did not affect viral loads in either the blood or lungs following challenge with the two heterologous PRRSV-1 strains. However, the BoHV-4-M-NSP5 prime-boost vaccination showed a marked trend toward reduced lung pathology following PRRSV-1 challenge. The limited effect of T cells on PRRSV-1 viral load was further examined by analyzing local and circulating T-cell responses using intracellular cytokine staining and proliferation assays. The results from this study suggest that vaccine-primed T-cell responses may have helped in the control of PRRSV-1 associated tissue damage, but had a minimal, if any, effect on controlling PRRSV-1 viral loads. Together, these results indicate that future efforts to develop effective PRRSV vaccines should focus on achieving a balanced T-cell and antibody response.
SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization
Authors: Chen Yu , Peng Fu , Yang Chao , Hou Huan , Xing Ziwei , Chen Junren , Liu Li , Peng Cheng , Li Dan
Published: August 2023

Background

Neuroinflammation has been reported as a potential contributing factor to brain diseases, and is characterized by activated microglia with release of multiple inflammatory mediators. 2,3,5,6-Tetramethylpyrazine (TMP) is an active alkaloid in Ligusticum chuanxiong Hort. and has various biological activities, including anti-inflammatory and neuroprotection properties. However, the anti-neuroinflammatory activity of TMP has been less studied and its potential molecular mechanisms in this field remain unclear. This study aimed to investigate the effects of TMP and its underlying mechanisms in neuroinflammation.

Methods

In vitro, lipopolysaccharide (LPS)-stimulated BV2 microglia were used to assess the effects of TMP on inflammatory cytokines as well as the components of the SIRT1/NF-κB signaling pathway, which were measured by using ELISA, western blotting, qRT-qPCR and immunofluorescence. Moreover, LPS-induced acute neuroinflammation model in mice was performed to detect whether TMP could exert anti-neuroinflammatory effects in vivo, and the EX527, a SIRT1 inhibitor, were given intraperitoneally every two days prior to TMP treatment. Serums and spinal trigeminal nucleus (Sp5) tissues were collected for ELISA assay, and the Sp5 tissues were used for HE staining, Nissl staining, immunofluorescence, qRT-PCR and western blotting.

Results

In vitro, TMP treatment significantly reduced the secretion of pro-inflammatory cytokines, including TNF-α and IL-6, promoted SIRT1 protein expression and inactivated NF-κB signaling pathway in LPS-induced neuroinflammation. Interestingly, pretreatment with EX527 blocked the therapeutic effects of TMP on neuroinflammation in vitro. Furthermore, TMP reduced the levels of pro-inflammatory cytokines and chemokines, and prevented microglia from polarizing towards a pro-inflammatory state through activating SIRT1 and inhibiting NF-κB activation in LPS-induced neuroinflammation in mice. And EX527 reversed the beneficial effects of TMP against LPS exposure in mice.

Conclusion

In summary, this study unravels that TMP could mitigate LPS-induced neuroinflammation via SIRT1/NF-κB signaling pathway.