bluuebunny/crossref_metadata_2025 huggingface dataset:
Stéréologie de l’interface dermo-épidermique
Authors: Pierard G.E. , Hermanns J.F. , Lapière C.M.
Published: October 2009

The architecture and the plasticity of the dermo-epidermal interface of normal and pathological human skin have been studied by scanning electron microscopy. Biopsies were incubated in a sodium bromide solution to dissociate the epidermis from the dermis. The cleavage plane was located at the level of the lamina densa of the basal membrane as evidenced by optical and transmission electron microscopy. The surface on either side has digital projections, presenting on the epithelial side the relief of the basal cells and on the dermal side the complementary architecture. The highly folded basement membrane can be considerably stretched and its architecture can be modified by two processes. A passive type results from movement transmitted to the basement membrane in response to mechanical stress. An active type, depending upon metabolic remodelling, is illustrated by the dermal downgrowth of basal cell carcinoma.
Direct Biochemical Assay of the Lipase Activity of Epidermis
Authors: Mier P.D. , van den Hurk José J.M.A.
Published: October 2009

The use of synthetic fluorogenic substrate has been applied to the measurement of lipase from guinea pig epidermis. The enzyme is not inhibited by Triton X-100 in concentrations up to 2 mg/ml, has a pH optimum in the range 6.5–8.5, a Km of 1.0 × 10––6 mol/l for 4-methyl umbelliferyl butyrate and possesses maximum activity towards esters of chain length C5–C6. The levels of activity observed seem sufficiently high to preclude bacterial flora as the major source. It is therefore concluded that skin possesses endogenous lipase activity.
On the Effect of Urea on Human Epidermis
Authors: Hellgren Lars , Larsson Kåre
Published: October 2009

The effect of urea on the horny layer of human epidermis has been studied with special regard to its osmotic and keratolytic effects. It has been shown that the water-binding capacity mainly must be of osmotic nature; the same effects could be achieved with about half the concentration (w/w) of sodium chloride. Pieces of upper epidermis kept in saturated urea solutions changed mechanically already after 1 week, and later it could be seen that the original quaternary structure of keratin is lost. No such changes could be seen in saturated sodium chloride solution. The results indicated that urea-containing creams, although certainly valuable in hyperkeratotic conditions, should be used with care as long-term cosmetical products.
Contact Hypersensitivity to Metallic Gold
Authors: Young E.
Published: October 2009

Two patients with a contact hypersensitivity to metallic gold are reported; one had a nodular skin reaction, the other had a reaction of the oral mucosa. Both patients gave strongly positive patch test reactions to gold trichloride. A review of literature is given.
Hautnebenwirkungen interner Arzneimittel
Authors: Zürcher K. , Krebs A.
Published: October 2009

This third part of a wider review offers tables with detailed information about cutaneous side-effects of cardiovascular and various other drugs affecting autonomic functions: gastrointestinal, pulmonary, some central nervous, as well as local anesthetics. The drugs capable of inducing lupus erythematosus and other collagen diseases are listed extensively in a special section. Based upon the immune deficiency concept of autoimmune disorders’, the hypothesis is presented that suppression of cellular immunity may be an important step in triggering drug-induced lupus erythematosus. This immuno-suppression could be either mediated by the sympatholytic action inherent to several of these drugs or caused directly by known hormonal effects or by a certain drug.
The Natural History of Psoriasis in 5,600 Patients
Authors: Farber Eugene M. , Nall Lexie
Published: October 2009

The natural history of psoriasis was studied through a questionnaire survey of 5,600 patients throughout the United States. The mean age of onset of psoriasis was 27.8 years. 36% of the respondents reported familial occurrence of the disease. At the time of study, the lower extremities were indicated as being the most often affected; trunk, elbow, and scalp were next, knee and face were cited less frequently. Fingernails were involved in half of the patients at some time during the period of their disease. In the majority of patients, hot weather and sunlight had a beneficial effect. One third of the females also indicated improvement during the course of pregnancy. Remissions were reported in 39% of the patients.
Le Synacthène-retard en thérapeutique dermatologique
Authors: Dubois-Ferrière G. , Hunziker N. , Orusco M.
Published: October 2009

106 patients affected by various skin diseases which did not respond to standard treatments, were improved or cured by a treatment of Synacthen-depot. There exist certain possible side-effects but these would seem to be less serious than those provoked by treatment with corticosteroids.
Vergleichende lokale Behandlungen von Basaliomen und senilen Keratosen mit 5-FluoruraciI, Vitamin-A-Säure und Dinitrochlorbenzol-Sensibilisierung
Authors: Remy W. , Stüttgen G.
Published: October 2009

The treatment of basal cell carcinomas and senile keratoses with 5-fluoruraciI, retinoic acid ointment or DNCB in alcohol is followed by local inflammation with an erosive reaction on the tumor surface. In comparison with nontreated basal cell carcinomas the infiltrations of the corium with lymphocytes and plasmacytes is increased. This phenomenon seems to be an immunological aggression against the tumor. From the immunological point of view, this observation is concerned with the finding that only the cells of the superficial basal cell carcinomas show contact with lymphocytes and plasmacytes. The local applications seem to be of therapeutic use only in the treatment of superficial basal cell lesions.
Dyskeratosis congenita Zinsser-Cole-Engmann Form with Abnormal Karyotype
Authors: Aguilar Robledo , Gomez Faustino , Sierra Tojo , Larripa P.
Published: October 2009

A typical case of dyskeratosis congenita (DC) is presented with its classic triad of poikiloderma, ungual dystrophy, and leukoplakial changes of the mucosal surfaces. The extensive involvement of the mucous membranes of the bronchial and gastrointestinal tracts is emphasized. For the first time, to our knowledge, chromosomal changes consisting of an increase in structural and numerical abnormalities are mentioned. Finally, some comments are made concerning the association of this disease with immunologic abnormalities, dysplasia of the reticulolymphoid and hematologic systems.
Causes of Fixed Drug Eruptions
Authors: Sehgal V.N.
Published: October 2009

Fixed drug eruptions (FDE) were investigated in 14 patients. The clinical pattern of the disease was classical. The causes of FDE were different in India as compared to other countries. Sulphonamides and analgesics were the commonest causes, though some other drugs such as tetracycline were also found to be responsible for this syndrome. Provocation tests were found useful.
Les antigènes d’histocompatibilité dans le psoriasis – corrélation avec l’arthropathie psoriasique; Études familiales
Authors: Guilhou J.J. , Meynadier J. , Seignalet J. , Guilhou E.
Published: October 2009

The HL-A typing of 90 psoriasic patients did not show any real correlation between histocompatibility antigens and psoriasic arthropathy. The study of families of 60 psoriasic patients has shown that the disease was twice as frequent among the close relatives of patients with W17 antigen. However, the HL-A typing of 4 families where several members were found to have the disease has shown that psoriasis may be transmitted independently of W17.
Vorkommen von intrazytoplasmatischen Desmosomen in Keratinozyten
Authors: Klug H. , Haustein U.-F.
Published: October 2009

Electron microscopic investigations on biopsies, taken from one patient with malignant melanoma and two with keratoma palmoplantare, have revealed that many keratinocytes contain numerous intracytoplasmic desmosomes, especially in melanoma. Most of them are interconnected by membrane structures for building large complexes. These intracytoplasmic desmosomes, which are 250–500 nm long and about 80 nm wide, partly show granular contact layer. The attachment plaques are surrounded by either filamentous or granular structures, which possibly induce the formation of the desmosomes. We suppose that these desmosomes partly come into the cytoplasm by invaginations of certain areas of the cell membrane, however, another part may be formed intracytoplasmically after invaginating of such sites of the cell membrane.
Development of Strength in Dequalinium Chloride-Treated Skin Incisions in Rat
Authors: Mobacken H. , Romanus M. , Wengström C.
Published: October 2009

Dequalinium chloride is a quaternary ammonium compound used for the treatment of infected skin and mucosal lesions. Its influence on the healing of incisional wounds in rat skin has been studied by a tensiometric technique. The breaking load was significantly lower in wounds that had been exposed to an aqueous solution of dequalinium chloride than those exposed to distilled water. The concentrations of dequalinium chloride were well below those used in clinical practice. The results obtained from incisional wounds are probably valid also for open wounds. The results are correlated with the microcirculatory disturbances demonstrated in previous studies. This suggests that the use of dequalinium chloride in treating human wounds should be re-evaluated.
Collection for Study of Small Amounts of Vesicular Fluid from Vesiculobullous Skin Diseases
Authors: Stevens David A.
Published: October 2009

A simple technique for aseptic quantitative recovery of small amounts of vesicular fluid for study has been devised. This technique has simplified serial observations of vesicular fluid in patients with infectious diseases and should be applicable to other vesiculobullous conditions.
Zum Problem der Kortikosteroid-Allergie
Authors: Gutzwiller P.
Published: October 2009

A short review on present-day knowledge of cortisone allergy is given and a case of a contact allergy to prednisone and prednisolone reported. The patch tests show that the strength of a positive reaction is influenced by the vehicle in which the cortisone is dissolved. This presents a possibility for further research with the aim of improving the ointment bases.
Osteoma Cutis
Authors: Vončina D.
Published: October 2009

Osteoma cutis of the left calf was found in a 3-month-old girl. Because of progression, the lesion was surgically removed after 4 years. The radiological and histological features of the lesion are illustrated. It seems very likely that this lesion arose as a primary osteoma cutis.
Satellitenförmige Rezidive bei teleangiektatischem Granulom
Authors: Zala L.
Published: October 2009

Following the normal electrosurgical treatment of a granuloma pyogenicum of the chin, a 55-year-old male responded with repeated relapses in the form of multiple nodules. Inspite of their alarming macroscopic aspect, such multiple satellite recurrences are not malignant. The etiology remains obscure.
UV Protective Effects of 5-FIuorouracil and Thymidine
Authors: Kahn Guinter , Curry Mary Catherine , Dustin Roberta
Published: October 2009

We confirm the previously claimed protection by 5-fluorouracil against ultraviolet radiation on the skin. We conclude that such protection is the result of absorption of erythema producing light (wavelengths less than 320 nm). Previously reported absorption of 5-fluorouracil in the 260– to 280-nm range was determined at concentrations several thousandfold less than those tested by us and used clinically. Our absorption studies, carried out in the clinical concentration range, show that 5-fluorouracil absorbs light even into long wave ultraviolet (greater than 320 nm). Such absorption occurs to a lesser extent with thymidine and accounts for the greater clinical protection achieved with 5-fiuorouracil.
Genealogische und zytogenetische Untersuchungen bei der hidrotischen Form der erblichen ektodermalen Dysplasie
Authors: Zlatkov N.B. , Konstantinova B.
Published: October 2009

Two cases of hidrotic hereditary ectodermal dysplasia are reported in father and son. The disease has an autosomal dominant pattern of inheritance. Out of the studied 21 members of the family 12 showed the same changes, namely, palmar and plantar keratodermia, pachyonychia, atrichia, hyperhidrosis and hypoplasia of the skin capillaries. The palmar keratodermia was especially pronounced in the father. The cytogenetic study of the patients displayed a high percentage of aneuploidy (chiefly of the hypodiploid type) and in the father a high percentage of endoreduplication (twins).
Pigmented Macules of the Tongue following Fixed Drug Eruption
Authors: Tagami H.
Published: October 2009

A case with fixed drug eruption involving only an unusual site is reported. The patient was a 35-year-old Japanese woman who showed bizzare pigmented macules on the dorsum of the tongue; they were demonstrated to have been caused by fixed drug eruption due to aminopyrine contained in a medicine for headache which she had taken occasionally for the past 10 years. The patient is regarded as a peculiar case of fixed drug eruption because of the following facts; (1) the fixed drug eruption affected only the tongue, and (2) it left markedly pigmented areas.
Treatment of Pemphigus and Pemphigoid with Azathioprine
Authors: van Dijk T.J.A. , van Velde J.L.
Published: October 2009

The results obtained with azathioprine in 10 patients with pemphigus and pemphigoid are reported. Seven of these patients showed a very good response to azathioprine alone. In two patients an initial high dosage of corticosteroids could be considerably reduced after azathioprine was added. In one patient a short initial azathioprine treatment gave noimprovement. Further investigations on the clinical usefulness of this drug are recommended.
Adrenal Suppression with Topical Hydrocortisone Butyrate
Authors: Hendrikse J.C.M. , Moolenaar A.J.
Published: October 2009

Hydrocortisone butyrate, when used topically in large quantities, can lead to suppression of the pituitary-adrenal system. This systemic effect apparently does not reduce pituitary-adrenal responsiveness.
Der Hautvasokonstriktionstest am Menschen als Prüfmethode für Externkortikoide
Authors: Weirich Erich G. , Lutz Ulrike
Published: October 2009

The effects of seven topical corticoids were compared in a series of cutaneous vasoconstriction tests, each carried out in a group of ten volunteers having similar types of skin, and whose dermal reactivity was already known. The preparations were applied, dissolved in 99% ethyl alcohol, on the flexor surfaces of the forearms of each subject in five different concentrations ranging from 10––3 to 10––7 w/w. The site of application was then covered with an occlusive dressing, which was left in place for 16 h. The degree of blanching resulting was recorded 2, 4, 8, 24, and 32 h after removal of the dressing. Cumulative analysis of the results of this series of tests on the basis of the mean effective doses (ED50) and the overall mean reaction scores for the entire observation period enabled the corticoids to be ranked as follows in ascending order of vasoconstrictive activity in relation to hydrocortisone. The mean effective doses, in particular, reveal distinct correlations with the clinical potency of these substances.
Studies on the in vitro Incorporation of 3H-Thymidine, 3H-Uridine, and 3H-Leucine into Mammalian Epidermal Cells
Authors: McDonald Charles J. , Los Linda J.
Published: October 2009

This report details the methods used and the results of our findings in a study that was designed to define, within the in vitro cell cycle of adult mammalian epidermal cells, the sequence of biochemical events leading to the synthesis of proteins and nucleic acids. DNA, RNA, and protein synthesis occurred throughout the series of experiments. Maximum DNA synthesis occurred at hours 9 and 28, suggesting a cell cycle time of 19 h. Maximum RNA synthesis occurred at 5, 14, 18 and 24 h. Minimum synthesis was noted at 12 h. Protein synthesis was constant throughout the series of experiments. These data are now being used to examine the temporal effects of endogenous and exogenous agents on the mammalian epidermal cell.
Glucose-6-Phosphate Dehydrogenase in the Blood of Psoriatics, and the Effects of Methotrexate
Authors: Cotton D.W.K. , van Rossum Elisabeth
Published: October 2009

The kinetic constants of glucose-6-phosphate dehydrogenase from the blood of psoriatics with and without methotrexate therapy have been determined. The constants were also determined in the blood of normal subjects and subjects suffering from atopic dermatitis and mycosis fungoides. No significant differences were found between subjects not receiving methotrexate. The subjects receiving methotrexate showed markedly increased Km values for both glucose-6-phosphate and NADP under the conditions used. The results are discussed in relation to psoriasis and its therapy.
Amine Oxidase Activity in the Skin of Rat
Authors: Bashey Reza I. , Mori Yo
Published: October 2009

A radioactive procedure was used to study and characterize amine oxidase activity in the skin of rat. Using 14C-tyramine it was shown that the skin has substantial amine oxidase activity equivalent to 60% of that present in the liver. No change was noted in the amine oxidase activity in the skins of rats after administration of β-aminopropionitrile (BAPN) and penicillamine. Some of the implications of this finding are discussed. Various inhibitors were utilized to compare the properties of skin and liver amine oxidases. There was no change in the amine oxidase activity in the skin of rat with age.
Versuch eines neuen Hautschnittes bei Probeexzisionen und Exzisionen kleinerer Hauttumoren
Authors: Huber H.P.
Published: October 2009

The cosmetic results of a skin biopsy technique using a sickle to half moon shaped incision and repaired with subcuticular purse-string type of suture inserted in a triangular shape have been compared with those of conventional excision biopsy techniques. The new technique resulted in significantly narrower scars in the majority of patients. Dexon, a non-tearing but absorbable synthetic suture material, was used.
Traitement de la blennorragie aiguë par le chlorhydrate de spectinomycine
Authors: Laugier P. , Orusco M.
Published: October 2009

181 patients, 40 women and 141 men, affected with acute gonorrhea were treated with a single dose of spectinomycine hydrochloride. Recovery rate was 98% for men and 100% for women. Authors estimate that spectinomycine hydrochloride is therefore the drug of choice in the treatment of acute gonorrhea and of great epidemiological interest. Since its treponemicidal effect is not well known, a controlled study of all treated subjects is essential.
Stearadenotroper Effekt von Androgenen am Kaninchenohr
Authors: Weirich Erich G. , Longauer Josef
Published: October 2009

The auricle of the rabbit ear appears particularly well suited as a histometrically evaluable model for assessing the reactions of the sebaceous glands to topical and systemic influences. Treatment of juvenile castrate rabbits with eight doses of 100 mg of a depot androgen (Triolandren®) over a period of 4 weeks led to a pronounced hyperplasia of the auricular glands: their average sectional area increased by 127% in relation to the initial values, whereas untreated control animals showed an increase of only 39% within the same period.
Squamous Cell Carcinoma and Keratoacanthoma in Discoid Lupus erythematosus
Authors: Farah Fuad S. , Matta Mona T. , Zeinoun Shukrallah , Shehadeh Samir I.
Published: October 2009

The association of discoid lupus erythematosus (DLE) and solar keratosis, squamous cell carcinoma, and keratoacanthoma in three different subjects prompted the study of the histologic changes in DLE. Seventy-one biopsies were examined and downward proliferation, dyskeratosis, disorganization, were found in various degrees as well as abnormal cells with prominent mitoses.
XYY Chromosome Complement in a Patient with Nodulocystic Acne
Authors: Sosis A.C. , Panet-Raymond G. , Goldenberg D.M.
Published: October 2009

A 14-year-old, very tall boy with severe nodulocystic acne was found to have the XYY chromosome complement, thus supporting previous studies suggesting an association between this dermatological lesion and the presence of an extra Y chromosome. It is conceivable that Y-controlled genes, regulating pilosebaceous cell function directly or through the production of an aberrant testosterone, are implicated in the pathogenesis of nodulocystic acne. Severe nodulocystic acne, especially early in life, may prove to be another phenotypic trait of the XYY syndrome.
Acquired Axillary and Inguinal Pigmentations
Authors: Jacyk W. , Miklaszewska M.
Published: October 2009

A patient with numerous macular pigmentations of the axillae and the groins is reported. Attention is called to the particular rarity of the presented melanotic abnormality.
Generalised Pustular Drug Rash
Authors: Macmillan A.L.
Published: October 2009

A generalised pustular rash occurred in four patients. Circumstantial evidence, time course and investigations exclude recognised pustular dermatoses and suggest that drugs provoked the rashes.
Calcinosis cutis Developing after Phlebitis
Authors: Miura Takashi , Akiba H. , Saito N. , Seiji M. , Tanaka S. , Okada Y.
Published: October 2009

Five cases of dystrophic calcinosis cutis that developed following phlebitis are reported. Phlebitis, thought to be a cause of calcification, occurred in blood vessels that had been used for infusion of various drugs, minerals, and Ringer’ solution during and after surgery. Several days after the onset of phlebitis, calcinosis cutis, which was characterized clinically by the development of small yellow papules arranged in linear or circular pattern, appeared to have developed along the blood vessels which had been subjected to infusions. The pathogenesis of calcium deposits occurring in these cases is discussed.
Scar Biopsy in Sarcoidosis
Authors: Paslin D.A. , Heaton C.L. , Wood Margaret Gray
Published: October 2009

Scar biopsies were performed on 25 patients with clinically established and histologically confirmed systemic sarcoidosis. Although none of the biopsied scars had undergone tumefaction and redness, three contained epithelioid granulomas.
The Therapeutic Effect of ε-Aminocaproic Acid on Anetoderma Jadassohn
Authors: Reiss F. , Linn Evelyn
Published: October 2009

The therapeutic results achieved in the treatment of anetoderma of Jadassohn with ε-aminocaproic acid is reported, which constitutes the first case in the literature which produced a permanent cure. Although the mechanism of action of ε-aminocaproic acid is not clear, the indisputable disappearance of the erythematous plaques and the subsequent prevention of the development of herniated lesions and bag-like protrusions are clear evidence of the therapeutic efficacy of this drug. Because an inflammatory process preceded these lesions, which was suppressed by the administration of ε-aminocaproic acid, the possibility is assumed that this anti-fibrinolytic drug may act by indirectly diminishing the amount of activity of the inflammatory peptides bradykinin, or similar substances.
Allergic Vasculitis with Atypical Localisation
Authors: Hendrikse J.C.M. , Suurmond D. , Smeenk G.
Published: October 2009

A 42-year-old man with recurrent attacks of blue-black haemorrhages predominantly on the palms and soles is described. Histology of a lesion revealed typical signs of allergic vasculitis. Direct immunofluorescence showed IgG and complement depositions in the vessel walls.
Vergleichende immunologische Untersuchungen der Haut-proteine bei einigen mit Schuppung einhergehenden Dermatosen
Authors: Sellei K. , Krebs A. , Schaltegger H.
Published: October 2009

In the epidermis and scales from patients having psoriasis two proteins were found immunologically which were not present in healthy skin. These are low molecular weight and relatively stable skin proteins and were found to be characteristic of, although not specific for, psoriasis, as they were also present in other exfoliative skin diseases.
Fibrinnachweis mit einem Enzym-Antiserum-Konjugat beim Lichen ruber planus
Authors: Ebner H. , Kraft D.
Published: October 2009

In 4 cases of lichen ruber planus, fibrin was demonstrated using the immunohistochemical technique described by Avrameas. In accordance with the results obtained by immunofluorescent microscopy, fibrin deposits could be revealed in a band-like pattern at the dermo-epidermal junction, as intra- and pericapillary masses and round- or ovoid-shaped bodies in the papillary region and basal layer of the epidermis.
The Origin of Dermal Fibrocytes in Wound Repair
Authors: Sumrall A.J. , Johnson W.C.
Published: October 2009

Whether blood mononuclear cells are totipotential and can give rise to fibrocytes is still controversial. Most recent studies seem to favor that fibrocytes arise locally from perivascular resting undifferentiated cells. We have attempted to determine the origin of fibrocytes utilizing tritiated thymidine (3HT) autoradiography. Multiple skin incisional wounds were produced in the dorsa of rats and a subsequent single intraperitoneal injection of 3HT was given at varying periods after injury. Biopsies were taken from individual animals at varying intervals up to 192 h after injury. Sections representing biopsies up to 15.5 h after injury, taken from animals injected at 4, 7, 8, and 11.5 h after injury, did not show labeling of monocytes, fibrocytes or endothelial cells. Biopsies taken from these same animals at varying intervals after 16 h showed labeling of these cells. These observations indicate that new-labeled fibrocytes which appeared in the wound were labeled at a distant site since labeling did not occur locally 1 h after a pulse injection of 3HT. Our findings thus support the concept that blood-borne mononuclear cells can give rise to some of the fibrocytic cells in repair of wounds.
Ungewöhnliche Kerneinschlüsse in Lymphozyten und Basalzellen der Haut bei Lupus erythematodes
Authors: Haustein U.-F.
Published: October 2009

In two patients with CDLE, inclusions were found in nuclei of lymphocytes of a chronic inflammatory skin infiltrate. The inclusions were similar to the known virus-like particles localized in the cytoplasma. They may represent nucleocapsids of an unknown virus. Origin and significance of inclusions observed in nuclei of necrobiotic basal cells in one patient with SLE are not clear.
A propos de l’étiologie du vitiligo
Authors: Brun Robert
Published: October 2009

Starting with the hypothesis that vitiligo could be a phenomenon of the same type as chemically induced leucoderma, we tried to find physiological or physiopathological derivatives of p-hydroxy-phenyl which could be responsible for the inhibition of melanogenesis. Thus, in the first place, we tested the inhibiting effect on many derivatives of tyrosine on a Dopa-melanocyte system. Our hypothesis was strengthened by the fact that two strong inhibitors were found in this group: p-hydroxy-pyruvic acid and p-hydroxy-phenyl-cinnamic acid. The derivatives of epinephrin are now being examined and the results will be published later.
Influence of Glycogen and Oligoglucosides on Glucose Oxidase Determination of Skin Glucose
Authors: Johnson J.A. , Fusaro R.M.
Published: October 2009

The interference of oligoglucosides (OG) in determination ofskin glucose with glucose oxidase reagent was investigated. It was observed that OG in pulverized rat skin entered the extraction medium and caused high glucose oxidase assay results. On the other hand, specimens obtained by rotary punch remained intact during the extraction procedure, and OG did not cause elevated glucose values. Rotary punch specimens of human skin yielded glucose oxidase values higher than those obtained in the presence of tris buffer, which prevents OG interference. It was demonstrated, however, that the elevated glucose yield was probably not due to the effect of OG. The data did not permit us to decide whether glucose oxidase assay is more reliable in the presence or absence of tris buffer. Consequently, our value for skin glucose content of fasting, nondiabetic humans is 42 or 49 mg/100 g wet weight, depending on which assay is more accurate.
Hormonal Factors in Dermatitis herpetiformis
Authors: Heim S. , Friedman-Birnbaum R
Published: October 2009

Two cases with dermatitis herpetiformis are described, a female and a male patient . In the first, the disease started following the intake of contraceptive pills and revealed periodic premenstrual exacerbations. In both cases the injection of estrogen and of progesterone induced an attack of the disease.
The Quantitative Analysis of some Constituents of Crude Sweat
Authors: Seutter E. , Annelies s , Sutorius H.M.
Published: October 2009

Crude sweat was obtained from patients suffering from atopic dermatitis, prurigo and acrocyanosis, and also from normal subjects. K, Cl, phosphate, sialic acid, Zn, Fe, Cu, and the activity as a co-substrate in the oxidation of NADH with catalase, were determined. The amount of analysable sialic acid increased 4.5 times by incubation with neuraminidase. The zinc concentration was about twice that of blood plasma. Significant positive correlations were found between Fe and Zn or Cu, and between the concentration before hydrolysis with neuraminidase and K or Cl. A significant negative correlation appeared between the activity as an oxidative co-substrate and the Zn concentration. In normal subjects, the Fe/K ratio was higher; in atopic dermatitis, Cu and Fe concentrations were lowered. In prurigo, Cl was lowered and Zn was raised. In acrocyanosis, the activity as an oxidative co-substrate was lowered. In normal subjects, the variability in the Cu concentration was lower.
Amiodarone-Pigmentierung
Authors: Matheis H.
Published: October 2009

Chronic administration of high doses of amiodarone for long time induces in some patients in the light-exposed areas of skin a cutaneous deposition of pigment, which consists of lipofuscin-like lipochrom. Clinically a 73-year-old woman, who received for 5 years daily 200–600 mg amiodarone, showed a peculiar metallic-blue coloration of the face.
Topical Administration of Vitamin A Acid (Retinoic Acid) in Palmar Keratoses: Callosities, Hyperkeratotic Eczema, Hypertrophic Lichen planus, Pityriasis rubra pilaris
Authors: Günther S.
Published: October 2009

20 patients suffering from different palmar keratoses were selected for a trial with retinoic acid under controlled conditions. The results can be summarised as follows: (1) in callosities the skin texture could be controlled by intermittent topical applications of retinoic acid once or twice weekly; (2) in hyperkeratotic eczema retinoic acid proved too irritant; (3) in hypertrophic lichen planus, retinoic acid was very effective and the improvement mostly permanent, and (4) in pityriasis rubra pilaris topically applied retinoic acid was found to be ineffective but the disease could be controlled when the substance was systemically administered. The side effects of such treatment are mentioned.
A Study of Vertical Sections of Normal Human Skin with the Scanning Electron Microscope
Authors: Wong C.K. , Vickers H.R.
Published: October 2009

A quick, easily prepared technique was used for examining the vertical sections of normal human skin with the scanning electron microscope. The epidermis and dermis were clearly distinguishable. The isthmus of the hair follicle, the cuticle of the hair shaft, the sebaceous gland and arrector pili muscle in the dermis were successfully shown with the present technique and the capillary pattern of the hair follicle was demonstrable.
Adverse Reaction Profiles of Drug Eruptions
Authors: Bruinsma W.
Published: October 2009

By plotting profiles of reported adverse reactions related to the skin, a fairly characteristic picture for each drug emerges. Analysis of these profiles provides useful data on the relative incidence of a particular adverse reaction due to individual drugs. Except for the long-acting sulfonamides, there are remarkable few differences between various chemotherapeutic agents in the incidence figures for erythema exsudativum multiforme-like reactions. Analysis of the data of the International Drug Monitoring Program might provide a new method for delineating the significance of drugs as aetiological factors in erythema multiforme, the Stevens-Johnson syndrome and toxic epidermal necrolysis
β-Carotene as a Treatment for Photohypersensitivity Due to Erythropoietic Protoporphyria
Authors: de la Faille Baart , Suurmond D. , Went L.N. , van Steveninck J. , Schothorst A.A.
Published: October 2009

The preliminary results obtained with stabilized and non-stabilized β-carotene in the oral treatment of photohypersensitivity in 25 protoporphyria patients are reported. β-Carotene appeared to have a beneficial effect in a majority of these patients. Carotinodermia was the only side-effect. Difficulties with regard to the evaluation of the results are discussed.
Zum Krankheitsbild der sogenannten «oral florid papillomatosis» (Papillomatosis mucosae oris carcinoides)
Authors: Richter G. , Engel S. , Jacobi Helga
Published: October 2009

Clinical and histological features, treatment and course of an ‘oral florid papillomatosis’ (OFP) observed in a 72-year-old woman are described. The discussion of all details published on OFP so far yields the following results: (1) men and middle-aged people as well as older persons are more highly to be affected by OFP; (2) even extremely large lesions still show criterias of the benign nature of OFP; (3) there is a strong tendency of recurrence; (4) methotrexate seems to give the best results in treating OFP; (5) development into malignant growth is possible, and (6) instead of the English name of ‘oral florid papillomatosis’, the name of ‘papillomatosis mucosae oris carcinoides’ is suggested.
Operability of Fortner’s Hamster Melanoma AMel 3
Authors: Haneke E. , Wohlrab W. , Peker J.
Published: October 2009

Golden hamsters were subcutaneously injected with melanoma cells and the prolongation of their survival time after the grown tumour was operated was compared with that of a non-operated control group. Hence it followed: (1) the survival time of the 15 operated hamsters was significantly prolonged; (2) despite the radicalness of the surgical operation, only 3 animals became tumour-free and survived; (3) when comparing the conditions of hamster melanoma AMel 3 to the human tumour with regard to the life-prolonging effect, one must absolutely recommend the surgical treatment; (4) statistical evaluation of the therapeutic effect is only possible with the aid of a very large number of patients because of the individuality of each human melanoma.
Effect of Anti-Inflammatory Compounds on β-Irradiation Induced Radiodermatitis
Authors: Chung J. , Song C.W. , Yamaguchi T. , Tabachnick J.
Published: October 2009

The effect of several anti-inflammatory agents given per os, intraperitoneally, or topically to alleviate acute radiodermatitis in guinea pig skin following 3,000 or 4,000 rep β-irradiation was studied. Up to the 21st day post-irradiation, there was pronounced suppression of the acute inflammatory response observed with chloroquine diphosphate, or meclofenamic acid (Cl-583). Chloroquine diphosphate given systemically was most potent among the single drugs tested. Qualitatively, combinations of the drugs given per os were somewhat more effective in suppression of the second erythema and late skin reactions. Topical application of 50% DMSO or of anti-inflammatory drugs dissolved in this solvent resulted in increased inflammatory reactions. Triamcinolone acetonide appeared to be the only active compound when applied topically. The effective anti-inflammatory agents decreased the frequency but did not prevent the onset of ulcers. Ulceration was delayed by about 10 days in the drug-treated animals (as compared with its appearance by the 20th day in controls) and the ulcerated area was smaller and healed more rapidly.
Allergic Contact Eczema Due to Chloracetamide
Authors: Smeenk G. , Prins F.J.
Published: October 2009

In the period from August, 1969, to December, 1970, 27 patients with a contact allergy to Hirudoid ointment have been seen. In 17 of these patients, it could be demonstrated, that this allergy was due to the presence of the preservative CA 24, containing chloracetamide. Therefore, the use of chloracetamide in creams and ointments for medical use has to be omitted.
Die Einführung des Chrysarobins in Europa
Authors: Weirich E.G. , Kettlewell P.J.
Published: October 2009

The antipsoriatic agent chrysarobin affords an excellent example of the insufficiencies in the codification of materia medica dermatologica. Of particular historical interest is the first monograph on crude chrysarobin, which was published in 1878 by the English dermatologist Balmanno Squire. It was this paper that gave the decisive impulse towards the general introduction of Goa powder extract into western medicine, and to its use as a remedy for psoriasis especially. The content of this monograph is reviewed and the question of therapeutic research into chrysarobin and its derivatives discussed.
Candidose nodulaire de la region inguino-génitale et des fesses (granuloma glutaeale infantum)
Authors: Delacrétaz J. , Grigoriu D. , de Crousaz H. , Tapernoux B. , Nicod P.-A. , Gautier E.
Published: October 2009

Three infants, 4 to 9 months old, treated for ‘seborrheic dermatitis’ with topical fluorinated corticosteroids present clinically nodular and histologically granulomatous lesions in the genito-inguinal regions and over the buttocks; mycological investigations and PAS stains of tissu sections show the presence of yeast elements identified as being Candida albicans. No general illness favoring the development of granulomatous candidiasis could be found. This fact together with the location of the eruption permit to suppose that the lesions are due to the application of fluorinated steroids, the treated region being covered with plastic pants over the diapers.
Goltz’s Syndrome: Focal Dermal Dysplasia Syndrome (Focal Dermal Hypoplasia)
Authors: Ishibashi A. , Kurihara Y.
Published: October 2009

The case of a Japanese girl who had deformities of bone and joints on the right side, and bilateral exanthemas and tooth anomaly (hypoplasia) is reported. This congenital disorder is a mesodermal ‘dysplasia’, with some ectodermal participation. In the literature, pedigrees of patients with familial occurrence suggest a dominant mode of inheritance; their family data do not deny the Goltz hypothesis that an excess number of females is due to genes which are lethal in males. New mutation should be present because selection was certainly present by the lack of offspring. There might be cases due to phenocopy. Possible environmental factors for maldevelopment were collected from the literature and from our case.
Zum Mechanismus der Hautgefässpermeabilitätserhöhung bei lokaler β-Bestrahlung der Haut
Authors: Oyvin I.A. , Gaponyuk P.Y. , Uklonskaja L.I.
Published: October 2009

Lokal inhibition of tissue respiration with cyanide slightly diminished the increased vascular permeability induced in rabbit skin with B-irradiation (00Sr + 99y, 9500 rad). These findings confirm the role of mediators of vascular permeability in the radiation induced increase of permeability as well as the direct vascular radiation damage.
Allergic Contact Dermatitis to Virginiamycin
Authors: Bleumink E. , Nater J.P.
Published: October 2009

A case of contact dermatitis to virginiamycin is described. This antibiotic was found to show cross-sensitization with pristinamycin.
Immunofluorescent Studies of Skin from Patients with Psoriasis
Authors: Heydenreich G. , From E. , Diederichsen H.
Published: October 2009

Immunofluorescent studies of lesions and uninvolved skin from 18 patients with psoriasis, 10 patients with psoriatic arthropathy and 2 patients with psoriatic erythrodermia did not reveal in vivo bound immunoglobulin, fibrinogen or complement, neither could circulating skin antibody be demonstrated in these patients.
Sweet’s Syndrome Simulating Systemic Lupus Erythematosus
Authors: Frayha Rida , Matta Muna , Kurban A.
Published: October 2009

A 37-year-old female with acute febrile neutrophilic dermatosis (Sweet’s syndrome) developed glomerular disease and other features mimicking systemic lupus erythematosus.
Dermatoglyphic Study of a Subject from Child to Adult by the Hygrophotographic Technique
Authors: Sivadjian J.
Published: October 2009

A study of the hygrophotographic records of the palmar surface of the right hand of a 9 year-old female subject was started in 1955 and continued until 1971, to the age of 25.It was noted that during the 16 years, there was no change in the palmar pattern of the right hand of this subject. The results indicate that this method might be useful for personal identification and in the study of genetical problems concerning der matoglyphics.
Kontaktallergie auf einige Lokaltherapeutika und Konservierungsmittel
Authors: Rudzki E. , Kleniewska Danuta
Published: October 2009

Sensitivity to some topical drugs and preservatives has been investigated in 1,440 patients. Only in the case of Balsam of Peru, neomycin, menthol and vioform has sensitivity been found to be decisively more frequent in long-term than in short-term patients. Sensitivity to topical drugs has been much more common in stasis dermatitis than in other forms of eczema. Tolerance of cosmetics by persons, in whom the contactants investigated had given positive tests, has often been poor.
Chloromycetinversager bei Gonorrhoe
Authors: Jadassohn W.
Published: October 2009

1. A patient acquired 2 gonococcical infections in an interval of 5 months from 2 different partners. Treatment with chloromycetin failed but with the use of Penbritin the patient was cured. 2. The fact that both infections were not cured by chloromycetin suggests to us not only to consider resisting germs but what happens in the organism of the patient with the chloromycetin he has taken.
Über ungewöhnliche subzelluläre Strukturen eines malignen Melanoms
Authors: Klug H. , Günther W.
Published: October 2009

Mitochondria with tubuli structures have been observed in all tumour cells of one malignant melanoma, whereas melanosomes and premelanosomes are present scarcely. Furthermore, many mitochondria contain unusual spherical structures which are limited by a double membrane. Besides many ribosomes and polysomes, there are numerous paracrystalline structures in the cytoplasm. No degenerative changes have been observed.
Verruca Vulgaris Associated with Changes of Darier’s Disease
Authors: Kaidbey K.H. , Farah F.S.
Published: October 2009

A verrucose lesion that developed over the forehead of a middle-aged man showed, on histological examination, changes characteristic of verruca vulgaris and Darier’s disease. The significance of this unusual association is discussed.
Acute Febrile Neutrophilic Dermatosis – Two Cases
Authors: Evans Susan , Evans C.C.
Published: October 2009

The clinical and histological findings of 2 patients with acute febrile neutrophilic dermatosis are described. Associated clinical features in 1 case suggest that a hypersensitivity reaction is responsible for this illness.
Effect of Topical Betamethasone-17-Valerate on Collagen Biosynthesis in Psoriatic Skin
Authors: Uitto J. , Hannuksela M.
Published: October 2009

The effect of topical betamethasone-17-valerate on collagen biosynthesis in skin was studied in patients with psoriasis. The skin specimens, taken from both lesion and normal-looking skin, were incubated in a medium containing 14C-proline and the rate of 14C-hydroxyproline formation was taken as an index of collagen biosynthesis. 10-day treatment decreased the rate of collagen formation in the lesion, whereas in normal-looking skin, no effect was detectable. The findings may have relevance to the local side-effects, such as atrophy of the skin, produced by fluorinated corticosteroids.
Generalized Dermatitis with Epidermal Eosinophilia Induced in Dinitrochlorobenzene-Sensitized Guinea Pigs
Authors: Skog E. , Wahlberg J.E.
Published: October 2009

DNCB- and DNCBSO3-sensitized guinea pigs were injected i.v. with DNCBSO3. The following phenomena were recorded: (1) the test reaction to DNCB was inhibited; (2) generalized dermatitis arose, and (3) eosinophilic infiltration occurred spotwise in the epidermis. DNCB- and DNCBSO3-sensitized guinea pigs were united with normal guinea pigs in arteriovenous anastomosis and the sensitized guinea pig was given DNCBSO3 i.v. The aforementioned phenomena occurred in the sensitized guinea pig. The normal guinea pig reacted with generalized dermatitis, but only in a few experiments with epidermal eosinophilia. The same results were obtained when the normal guinea pig was injected with DNCBSO3.
Unusual Skin Lesions of Rheumatoid Arthritis
Authors: Baker, jr. R.J. , Johnson W.C. , Burgoon, jr. Carroll F.
Published: October 2009

Two patients are reported with the usual manifestations of rheumatoid arthritis but they also had widespread atypical cutaneous papules, nodules, and ulcerated lesions of the legs. The histopathologic changes in the skin in both patients showed multiple areas of necrobiosis with peripheral palisading of fibrocytes at all levels in the corium, thickening and obliteration of small blood vessels, fibrinoid degeneration, and a granulomatous vasculitis. The ulcers developed in preexisting plaques or nodules. The histopathologic features of a granulomatous vasculitis, the rising levels of macroglobulins and latex rheumatoid arthritis factor are compatible with the cutaneous lesions being due to an immunologic reaction involving the cutaneous blood vessels and extravascular connective tissue.
Lamprene: First Results of Treatment in the Netherlands in a Group of 6 Leprosy Patients
Authors: Hogerzeil L.M.
Published: October 2009

This paper reports the use of Lamprene (clofazimine) in 6 patients suffering from long-standing lepromatous or borderline leprosy (average duration 17 years) who were intolerant of both dapsone and thiambutosine. The skin lesions improved and reactions decreased in every patient except one. A case of severe polyneuritis responded favourably. Tolerance to dapsone was temporarily increased and steroid dependence reduced. The clinical improvement was matched by the bacteriological one, the morphological index falling to zero within 7 months. No indication of resistance to Lamprene was seen and no side-effects were noted, except a ruddy or slate-grey discoloration of the skin.
Further Electron-Microscopic Observations of Mycobacterium lepraemurium
Authors: Hasegawa T.
Published: October 2009

Murine lepromas were fixed in a phosphate-buffered 5% glutaraldehyde solution and then postfixed in a phosphate-buffered 1% OsO4 solution. Specimens were dehydrated and embedded in Epon 812. In this preparation, the fine structure of the bacilli was clearly observed. An opaque coating substance was observed around each bacillus. This substance is probably not only lipid, but also protein in nature.
Reactive Nodular Hyperplasia of Hands and Oral Mucosa
Authors: Saylan T. , Marks R. , Jones Wilson
Published: October 2009

9 patients with acquired solitary nodules on the hands and 8 others with similar lesions on the oral mucosa are described together. The commonest sites of involvement were the palm and palmar aspects of the fingers and the tongue; in general they were asymptomatic. Histologically the lesions contained young connective tissue and the view is expressed that they represent a reaction to minor trauma.
Hypersensitivity and Photosensitivity to Chlorhexidine
Authors: Wahlberg J.E. , Wennersten G.
Published: October 2009

A case of hypersensitivity to chlorhexidine is described. When test areas were irradiated in different ways, stronger test reactions were obtained. Wood’s light produced the most distinct intensification of the effect; the patient reacted to 0.0156%, compared with 0.125% chlorhexidine solution without irradiation. Absorption maxima are reported and the possibility of photoallergy is discussed.