bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Chinese steamed bun and bread processing on pesticide residues in wheat flour
Authors: Liang Ying , Duan Jinmiao , Gao Qingchao , Li Yahui , Zhang Zhiyong
Published: June 2022

The changes of five pesticides including imidacloprid, triadimefon, fenitrothion, chlorpyrifos-methyl, and chlorpyrifos in wheat flour during Chinese steamed bun and bread processing were systematically investigated. The pesticide residues were determined by high performance liquid chromatography coupled with diode array detector. Dough mixing step in both Chinese steamed bun and bread processing reduced the concentration of five pesticide residues significantly by 33 to 46%. It was mainly attributed to the increase of moisture content in mixed dough during this step. The reduction of pesticides in fermenting step varied from 2 to 22% in Chinese steamed bun and bread processing. Resting step in both Chinese steamed bun and bread processing has little effect on the pesticide residues with the reduction from 2 to 8%. The five pesticides have different behaviours in steaming step of Chinese steamed bun processing and in baking step of bread processing. During the steaming step, only the concentrations of triadimefon and imidacloprid residues in crust were increased by 52 and 1%, the others in crust and in crumb of Chinese steamed bun were decreased by 4 to 38%. After the baking step, the concentrations of triadimefon and imidacloprid residues in crust, and the triadimefon residue in crumb of bread were increased by 65, 83, and 14%, respectively, the others were all reduced. The processing factors (PFs) for triadimefon and imidacloprid in crust in the steaming and baking steps, for triadimefon in crumb in the baking steps were greater than 1, and the others were all less than 1. Overall, this study provides important references for monitoring pesticide residues in the processing of wheat flour products. The PFs obtained could be helpful for the risk assessment of pesticides in wheat flour products.
Trastuzumab deruxtecan (T-DXd) versus treatment of physician’s choice (TPC) in patients (pts) with HER2-low unresectable and/or metastatic breast cancer (mBC): Results of DESTINY-Breast04, a randomized, phase 3 study.
Authors: Modi Shanu , Jacot William , Yamashita Toshinari , Sohn Joohyuk , Vidal Maria , Tokunaga Eriko , Tsurutani Junji , Ueno Naoto T. , Chae Yee Soo , Lee Keun Seok , Niikura Naoki , Park Yeon Hee , Wang Xiaojia , Xu Binghe , Gambhire Dhiraj , Yung Lotus , Meinhardt Gerold , Wang Yibin , Harbeck Nadia , Cameron David A.
Published: June 2022

LBA3

Background: About 55% of mBC typically categorized as HER2 negative, express low levels of HER2 (IHC 1+ or IHC 2+/ISH− by ASCO/CAP 2018 guidelines) with poor outcomes in later lines (Tarantino 2020). T-DXd has shown promising efficacy in HER2-low mBC in a phase 1 study (NCT02564900; Modi 2020). This is the primary report from DESTINY-Breast04 (NCT03734029), the first randomized, multicenter, open-label, phase 3 study comparing efficacy and safety of T-DXd vs TPC in pts with HER2-low mBC treated with 1-2 prior lines of chemotherapy in the metastatic setting. Methods: 557 pts with centrally confirmed HER2-low mBC were randomly assigned 2:1 to T-DXd 5.4 mg/kg or TPC (capecitabine, eribulin, gemcitabine, paclitaxel, or nab-paclitaxel). The primary endpoint was progression-free survival (PFS) determined by blinded independent central review (BICR) in pts with hormone receptor–positive (HR+) mBC. Key secondary endpoints (hierarchically tested after the primary endpoint) include PFS by BICR in the full analysis set (FAS; HR+/−) and overall survival (OS) in pts with HR+ mBC and in FAS. Other endpoints were objective response rate, duration of response, safety, and an exploratory analysis of pts with HR− mBC. Results: As of Jan 11, 2022, 373 and 184 pts (88.7% and 88.6% HR+ mBC) were assigned to T-DXd and TPC, respectively. Median follow-up was 18.4 months (mo; 95% CI, 17.9-19.1). Median treatment duration was 8.2 mo (range, 0.2-33.3) with T-DXd and 3.5 mo (range, 0.3-17.6) with TPC. Efficacy results are in the Table. 52.6% of pts with T-DXd vs. 67.4% of pts with TPC had grade (G) ≥ 3 treatment-emergent adverse events (TEAEs). With T-DXd, 45 pts (12.1%; 10.0% G1/2, 1.3% G3/4, 0.8% G5) had independently adjudicated drug-related interstitial lung disease [ILD]/pneumonitis vs. 1 pt (0.6% G1) with TPC. Conclusions: DESTINY-Breast04 is the first phase 3 trial of a HER2-directed therapy in pts with HER2-low mBC to show a statistically significant and clinically meaningful benefit in PFS and OS compared to standard-of-care treatment, regardless of HR status, with a generally manageable safety profile. Funding: Daiichi Sankyo, Inc., and AstraZeneca. Clinical trial information: NCT03734029. [Table: see text]
Phase 3 randomised study evaluating the addition of low-dose nivolumab to palliative chemotherapy in head and neck cancer.
Authors: Patil Vijay Maruti , Noronha Vanita , Menon Nandini Sharrel , Bhattacharjee Atanu , Kumar Suman , Purandare Nilendu , Agrawal Archi , Puranik Ameya , Nawale Kavita Prakash , Jogdhankar Shweta , Alone Mitali , Tambe Rupali , Sawant Riddhi , Kalra Devanshi , Dhumal Sachin Babanrao , Banavali Shripad Dinanath , Prabhash Kumar
Published: June 2022

LBA6016

Background: The regimens approved for the treatment of advanced head and neck squamous cell carcinoma (HNSCC) are accessible to only 1-3% of patients in low and middle-income countries due to cost. In our previous study, metronomic chemotherapy (MC) improved survival in this setting. Retrospective data suggest that a low dose of nivolumab may be efficacious. Hence, we aimed to assess whether the addition of low dose nivolumab to MC improved the overall survival. Methods: This was a randomised phase 3 superiority open-label study. Adult patients with relapsed -recurrent or newly diagnosed advanced HNSCC being treated with palliative intent with ECOG PS 0-1 were eligible. Patients were randomised 1:1 to MC consisting of methotrexate 15 mg/m2 PO weekly, celecoxib 200 mg PO daily and erlotinib 150 mg PO daily, or MC with intravenous nivolumab 20 mg flat dose once-every-3-weeks. Therapy was continued until disease progression or intolerable adverse events. Response assessment (RECIST version 1.1) was performed every 2 months. The primary endpoint was 1-year overall survival (OS) and this was a pre-specified interim analysis with the nominal p-value for efficacy being 0.006. Results: 151 patients were randomised, 75 in MC and 76 in the MC-I arm respectively. The addition of low dose nivolumab led to an improvement in the 1-year overall survival from 16.3% (95%CI 7.95-27.4) to 43.4% (95% CI 30.8-52.3) [Hazard ratio-0.545; 95%CI 0.362-0.82; P=0.00358]. The median overall survival in MC and MC-I arms was 6.7 months (95%CI 5.83 -8.07) and 10.1 months (95%CI 7.37-12.63) respectively (P=0.0052). The median progression-free survival in MC and MC-I arms was 4.57 months (95%CI 4.2 -5.3) and 6.57 months (95%CI 4.43-8.9) respectively (P=0.0021). Response rate in MC and MC-I arm were 49.3% (95% CI 37.8-60.8) and 65.2% (95%CI 53.4-75.4) respectively (P=0.085). The rate of grade 3 and above adverse events was 50% and 46.1% in MC and MC-I arm respectively (P=0.744). Conclusions: In this first-ever randomised study, the addition of low dose nivolumab led to improved overall survival and is an alternative standard of care for those who cannot access full dose nivolumab. Clinical trial information: CTRI/2020/11/028953.
Distant metastasis-free survival with pembrolizumab versus placebo as adjuvant therapy in stage IIB or IIC melanoma: The phase 3 KEYNOTE-716 study.
Authors: Long Georgina V. , Luke Jason J. , Khattak Muhammad , de la Cruz Merino Luis , Del Vecchio Michele , Rutkowski Piotr , Spagnolo Francesco , Mackiewicz Jacek , Chiarion-Sileni Vanna , Kirkwood John M. , Robert Caroline , Grob Jean-Jacques , de Galitiis Federica , Schadendorf Dirk , Carlino Matteo S. , Wu Larry , Fukunaga-Kalabis Mizuho , Krepler Clemens , Eggermont Alexander M. , Ascierto Paolo Antonio
Published: June 2022

LBA9500

Background: In previous analyses of the phase 3, double-blind KEYNOTE-716 study, adjuvant pembrolizumab (pembro) significantly improved recurrence-free survival compared with placebo in patients (pts) with resected AJCC-8 stage IIB or IIC melanoma. We present new data from the analysis of distant metastasis-free survival (DMFS), and recurrence-free survival (RFS) with longer follow up. Methods: A total of 976 pts aged ≥12 years with complete resection of cutaneous stage IIB or IIC melanoma and negative sentinel lymph node biopsy were randomized 1:1 to pembro 200 mg (2 mg/kg for pediatric pts) or placebo Q3W for 17 cycles (approximately 1 year) in Part 1 of the study. Randomization was stratified by T category 3b, 4a, 4b (adults) with a separate stratum for pediatric pts. Treatment continued until disease recurrence or unacceptable toxicity. Pts who received placebo in Part 1, or who did not experience disease progression within 6 months of completing Part 1 were eligible for additional cycles of pembro Q3W at recurrence (Part 2). The primary endpoint was RFS per investigator. DMFS by investigator is a secondary endpoint. The data cut-off date for this interim analysis was Jan 4th, 2022. Results: At median follow-up of 26.9 mo (range, 4.6-39.2), adjuvant pembro significantly improved DMFS (HR 0.64, 95% CI, 0.47-0.88; P=0.0029; median not reached [NR] for both) vs placebo. The 24-mo DMFS rate was 88.1% vs 82.2%. There was consistent reduction in the risk of recurrence with pembro vs placebo (HR 0.64, 95% CI, 0.50-0.84) with further follow-up. The 24-mo RFS rate was 81.2% vs 72.8%. Grade ≥ 3 any-cause AEs occurred in 137 (28.4%) vs 97 (20.0%) pts in the pembro vs placebo arms. Grade ≥ 3 drug-related AEs occurred in 83 (17.2%) vs 24 (4.9%) pts. One pt in the pembro arm and 5 pts in the placebo arm died due to an any-cause AE. No deaths were drug-related. Immune-mediated AEs occurred in 182 (37.7%) vs 45 (9.3%) pts, most commonly hypothyroidism (17.2% vs 3.7%). Conclusions: Adjuvant pembrolizumab vs placebo for resected stage IIB and IIC melanoma significantly improved DMFS, with continued reduction in the risk of recurrence, and a favorable benefit-risk profile. Clinical trial information: NCT03553836.
Enclosing the Seas
Authors: Mathew Johan
Published: June 2022

This article outlines a process of enclosing private property on the Arabian Sea through the colonial imposition of secure property rights during the nineteenth century. The article proceeds in two paralleled sections. The first section explores the violence of the natural world through the lens of shipwrecks. It traces a shift in the right to shipwrecked property from littoral communities to the merchants who owned the cargo before it was seized by the waves. The second section traces the shift from merchants who deployed violence as an essential tool in commercial competition, to relying on the British Empire for the security of their property and the strategic use of force. On the one hand, both these transitions involve the imposition of classical political economy and the colonial seizure of protection rents obtained by merchants. However, they also reflect the ways in which maritime potentates and influential merchants were able to co-opt imperial policies and profit from this transition. Over the course of the nineteenth century, violent coercion was expunged from the skillset of Arabian Sea merchants, but only after compensating merchants and coastal communities for relinquishing the profits of protection.
Neurosurgical Complications: Forgive and Remember
Authors: Morcos Jacques J.
Published: June 2022

Neurosurgical complications are unfortunately unavoidable events in our field. Notwithstanding the potentially devastating effect they can have on patients' lives, young neurosurgeons may equally feel devastated by their occurrence and find themselves poorly equipped emotionally to handle them. There is a significant literature discussing the psychological repercussions of these events. This special article, written in essay format, is simply a brief overview of the seasoned author's personal approach to complication avoidance and management, with an emphasis on the behavioral aspects and humane dimensions of our profession. The younger trainee may find value in the ideas and emotions expressed here, and the seasoned neurosurgeon may well identify with the author's thoughts.
Η χρήση των Γνωστικών Προκλητών Δυναμικών στην αξιολόγηση της θεραπευτικής αντιμετώπισης σε παιδιά και εφήβους με ψυχοπαθολογικές διαταραχές
Authors: Ζυγούρης Νικόλαος
Published: June 2022

Οι αγχώδεις διαταραχές και η κατάθλιψη είναι από τις πλέον αυξανόμενες σε συχνότητα εκδηλώσεις ψυχοπαθολογίας που εμφανίζονται στα παιδιά και τους εφήβους. Η εκδήλωσή τους από πολλούς ερευνητές υποστηρίζεται ότι συνδυάζεται με σημαντική έκπτωση των Γνωστικών λειτουργιών με αποτέλεσμα να επιφέρει τη χαμηλή ακαδημαϊκή επίδοση. Στο παρόν ερευνητικό πρωτόκολλο γίνεται μια προσπάθεια διερεύνησης των διαταραχών αυτών με τη μέθοδο των Γνωστικών Προκλητών Δυναμικών, ένα εργαλείο που με ανώδυνο τρόπο μετράει την ηλεκτροεγκεφαλική δραστηριότητα που εκλύεται από τον εξεταζόμενο όταν καλείται να ανταποκριθεί σε ένα ερέθισμα. Βασικός στόχος της συγκεκριμένης αξιολόγησης είναι αφενός ο εντοπισμός των διαφορών των παιδιών και των εφήβων που έχουν λάβει τη διάγνωση κατάθλιψη ή Γενικευμένη Αγχώδη Διαταραχή σε σχέση με την ομάδα ελέγχου σε επίπεδο εγκεφαλικής δραστηριότητας και αφετέρου η αξιολόγηση της αποκατάστασης τους μετά τη χρήση συγκεκριμένων ψυχοθεραπευτικών τεχνικών και ψυχοφαρμακολογίας. Για το σκοπό αυτό αξιολογήσαμε 16 παιδιά (8 αγόρια και 8 κορίτσια) που είχαν λάβει τη διάγνωση κατάθλιψη από το Παιδοψυχιατρικό Νοσοκομείο Αττικής και 16 παιδιά (8 αγόρια και 8 κορίτσια) που είχαν λάβει τη διάγνωση Γενικευμένη Αγχώδη Διαταραχή και συγκρίναμε τους χρόνους έκλυσης της βασικότερης κυματομορφής των Γνωστικών Προκλητών Δυναμικών του Ρ300 με αντίστοιχα (Ν=32) παιδιά της ομάδας ελέγχου. Παράγοντα αποκλεισμού από την πειραματική ομάδα αποτελεί το γεγονός ότι έπρεπε ο κάθε συμμετέχοντας να αξιολογείται για πρώτη φορά με βάση την ψυχοπαθολογία του προκειμένου να μην έχει κάνει χρήση καμίας τεχνικής αποκατάστασης, μεταβλητή που θα μπορούσε να αλλοιώσει το χρόνο έκλυσης της κυματομορφής Ρ300. Από τα αποτελέσματα της έρευνας γίνεται αντιληπτό ότι τα Γνωστικά Προκλητά Δυναμικά αποτελούν ένα αξιόπιστο εργαλείο στον εντοπισμό των διαφορών μεταξύ παιδιών με κατάθλιψη ή άγχος σε σύγκριση με την ομάδα ελέγχου. Σημαντικό, επίσης, κρίνεται το γεγονός ότι από τη στατιστική ανάλυση προκύπτει ότι η συγκεκριμένη μέθοδος αποτελεί ένα μέσο διαφοροδιάγνωσης μεταξύ παιδιών με άγχος και παιδιών με κατάθλιψη. Επιπλέον, σημαντικές διαφορές εντοπίστηκαν στο χρόνο έκλυσης της κυματομορφής Ρ300 όταν στα παιδιά με ψυχοπαθολογία εφαρμόστηκε πρόγραμμα αποκατάστασης που συνδύαζε ψυχοθεραπεία και ψυχοφαρμακολογία. Συμπερασματικά, γίνεται κατανοητό το γεγονός ότι η συγκεκριμένη τεχνική μπορεί να αποτελέσει μια αντικειμενική δοκιμασία στον τομέα της διάγνωσης των παιδιών και των εφήβων με κατάθλιψη ή άγχος καθώς επίσης και στον τομέα της αξιολόγησης του προγράμματος αποκατάστασης που ως στόχο πρέπει να έχει τη βελτίωση των γνωστικών λειτουργιών των συγκεκριμένων παιδιών. Με βάση αυτό θεωρούμε ότι η αυτή έρευνα δεν εντάσσεται αποκλειστικά στα πλαίσια της Νευροψυχολογίας, αλλά εκτείνεται και στο γνωστικό αντικείμενο της ειδικής αγωγής μια και τελικό αποτέλεσμα είναι η βελτίωση της ακαδημαϊκής επίδοσης των παιδιών και των εφήβων με κατάθλιψη ή Γενικευμένη Αγχώδη Διαταραχή.
Διαχείριση της συντήρησης οδικών γεφυρών στο κύκλο ζωής τους υπό σεισμικό κίνδυνο
Authors: Τσίκας Παναγιώτης
Published: June 2022

Οι οδικές γέφυρες είναι έργα μεγάλης κλίμακας, αυξημένων απαιτήσεων και υψηλού κόστους, οι οποίες κατασκευάζονται για να εξυπηρετήσουν ανάγκες μετακινήσεων προσώπων και μεταφοράς αγαθών στη διάρκεια ζωής τους. Η ύπαρξη γεφυρών μεγάλης ηλικίας στο οδικό δίκτυο και οι εικόνες βλαβών που παρατηρούνται σε αυτές μετά από σεισμούς αναδεικνύουν την ανάγκη έγκαιρης και αποτελεσματικής συντήρησης και αποκατάστασης των. Για να επιτευχθούν τα αναμενόμενα αποτελέσματα χωρίς υπέρμετρες οικονομικές επιβαρύνσεις, η συντήρηση θα πρέπει να συνδέεται και με την οικονομικότητα η οποία επιτυγχάνεται μέσω της κατάλληλης διαχείρισης, της βελτιστοποίησης δηλαδή των αποφάσεων επιλογής, σχεδιασμού και υλοποίησης των παρεμβάσεων συντήρησης. Η παρούσα έρευνα έχει ως στόχο την εκτίμηση του σεισμικού κίνδυνου και τη βέλτιστη διαχείριση της συντήρησης οδικών γεφυρών με την αξιοποίηση σύγχρονων μεθόδων υπολογιστικής νοημοσύνης για την εκτίμηση της κατάστασης των γεφυρών ενός δικτύου στο χρόνο και την επιλογή των κατάλληλων διορθωτικών παρεμβάσεων που οδηγούν στα υψηλότερα δυνατά επίπεδα ασφάλειας και λειτουργικότητας υπό τους υφιστάμενους περιορισμούς διαθεσιμότητας πόρων. Στο πλαίσιο αυτό αναπτύσσονται μεθοδολογίες (οι οποίες στη συνέχεια υλοποιούνται σε υπολογιστικό σύστημα) που περιλαμβάνουν (α) την εκτίμηση της σεισμικής διακινδύνευσης γεφυρών με βάση μια σειρά παραμέτρων που αφορούν στη γέφυρα καθεαυτή και στο χώρο όπου αυτή εντάσσεται, (β) την εκτίμηση της εξέλιξης της κατάστασης στο χρόνο (με τη δημιουργία καμπυλών κατάστασης), η οποία αποτελεί σημαντικό παράγοντα στη διαδικασία αποφάσεων συντήρησης και αποκατάστασης και (γ) τη βελτιστοποίηση της στρατηγικής συντήρησης με την δόμηση και συγκριτική αξιολόγηση (μεγάλου αριθμού) εναλλακτικών σεναρίων που περιλαμβάνουν το είδος της συντήρησης, τη γέφυρα εφαρμογής (ειδικότερα το στοιχείο της γέφυρας) και το χρόνο εφαρμογής. Στην πορεία υλοποίησης χρησιμοποιούνται διάφορες ομάδες εργαλείων υπολογιστικής νοημοσύνης όπως μετα-ευρετικοί αλγόριθμοι βελτιστοποίησης, νευρωνικά δίκτυα, ασαφή συστήματα, κλπ. Λόγω του μεγέθους και της πολυπλοκότητας του προβλήματος, η εφαρμογή τέτοιων μεθόδων αναγκαία προκειμένου να επιτευχθούν ικανοποιητικά αποτελέσματα αναφορικά με την ακρίβεια των λύσεων και το υπολογιστικό φορτίο.Στο πλαίσιο της διερεύνησης υλοποιήθηκαν πιλοτικές εφαρμογές με πραγματικά στοιχεία γεφυρών και εξετάστηκαν διαφορετικά σενάρια ως προς τις παραμέτρους των επιμέρους προβλημάτων με στόχο να αναδειχθούν οι δυνατότητες των προτεινόμενων μεθοδολογιών αλλά και να υπάρξει μια ολοκληρωμένη εικόνα της αξιοπιστίας αυτών μέσω αναλύσεων ευαισθησίας. Τα αποτελέσματα των εφαρμογών δείχνουν ότι το σύστημα μπορεί να παρέχει αξιόπιστες λύσεις στα επιμέρους θέματα που αντιμετωπίζει, με αποτελέσματα που είναι σταθερά, κοντά στην πραγματικότητα και σε αυτά άλλων εφαρμογών (όπου ήταν δυνατή η σύγκριση) και σε μορφή πλήρως αξιοποιήσιμη για τη στήριξη αποφάσεων διαχείρισης δικτύου γεφυρών στον κύκλο ζωής τους.
Stress and its association with involvement in online classes: a cross-sectional study among undergraduate students of a medical college in South India
Authors: Motappa Rohith , Sachith Malavika , Raghuveer Pracheth
Published: June 2022

Background: With the implementation of lockdown and all students restricted to their houses, medical education has shifted towards the online mode. The objective of this study was to assess stress during the pandemic and the association between stress and involvement in online classes among students of a medical college in Mangalore, Karnataka, South India.

Methods: A cross-sectional study was conducted among 324 undergraduate students at a medical college in Mangalore, Karnataka, South India. The extent of stress was assessed using a perceived stress scale (PSS), and a questionnaire was used to identify different stressors and to understand the participant’s involvement in online classes.

Results: In this study, the mean perceived stress score was 21.66 ± 4. Moderate stress was observed in 262 (85%) students. The main stressors noted were inability to focus (173 (56.4%)) and fear of exams (153 (49.8%)). A significant association was noted between stress and involvement in online classes.

Conclusions: This study thereby highlights the need for more attention to the various stressors among students and for making online classes student friendly.
The Squash that Conquered America: Pumpkin Symbolism in the United States
Authors: Kapek Maciej
Published: June 2022

Pumpkin has always played an important role in American culture. Throughout history, it carried a plethora of meanings and connotations. Since European arrival to the New World, the meaning of the squash changed drastically from a product crucial for survival due to its practical features to the one that carries primarily a symbolic meaning. The shift happened by series of small changes with a significant impact of fall holidays: Thanksgiving and Halloween. Thanks to them, the squash began to be associated not only with the seasonal traditions, but with America itself. The pumpkin constantly appears in cultural texts such as poems and graphics, usually as a symbol of the fall or one of the holidays of that part of the year, although some representations depict it as an emblem of the American nation. Its association with the United States is now recognized across the world. At the same time, pumpkin significance extends and evolves into new forms. In modern America, it is not the pumpkin itself that reminds of the fall, but the spice based on a pumpkin pie. Thus, pumpkin becomes a link in a chain of symbolic references.
The Paradox of Strategizing: Embracing Managerial Agency without Throttling it
Authors: Spender J.-C , Kraaijenbrink Jeroen
Published: June 2022

Strategizing implies making agentic choices in some middle ground between un-analyzable free will and agency-denying determinism. Paradoxically, neither view can capture the strategist’s situation or process. So how are strategy theorists approach agency? In our opening sections, we review the mainstream literature and find seven main arguments or tracks. Five, by improving methodological accuracy and reducing variance, effectively throttle or deny the strategist’s agency. The two other tracks offer agency an ontological or epistemological place in the analysis but underplay the synthetic nature of the strategist’s practice. In our final sections, we treat strategizing as handling the practice-based constraints to the strategist’s agency. A positivist approach makes little sense here for ex definition strategy supposes a finite option-space into which the strategist’s agency is ‘thrown’. Practitioners focus on their choices within this space rather than on the application of a generalized ‘theory of strategy’. There is little new here; but analyzing it means moving away from causal modeling and towards exploring the options remaining after all reasonable determining causes have been identified - leaving the strategist with the under-determined middle ground s/he ‘synthesizes’ from incommensurable theories and empirically justified heuristics. Concluding, we propose a novel track of theorizing for those strategists seeking to engage their agentic capabilities rather than theorizing about agency as a component of a rigorous academic model.
O pensamento de Heidegger como abertura para uma ecofenomenologia
Authors: De Barros Gabriel De Almeida
Published: June 2022

A filosofia de Martin Heidegger permitiu repensar e fundamentar assuntos que já eram, até então, largamente discutidos. Não só a mudança de foco da questão filosófica, a qual ele trouxe de volta para a discussão do ser, assim como o aperfeiçoamento do método fenomenológico, serviram de base para que diversos assuntos pudessem ser discutidos por novas perspectivas. Dentre essas discussões, seu pensamento tem possibilitado um novo fôlego para o desenvolvimento da temática ambiental, uma discussão que não parte da natureza como objeto de estudo, mas sim de sua relação intrínseca com o ser humano. Discuto, nesse artigo, a urgência de uma nova perspectiva para o debate ambiental e a partir de quais aspectos da obra do filósofo podemos aprofundá-lo dando base para o que chamamos de ecofenomenologia. Verifico então o sentido originário de natureza que Heidegger busca no grego physis, sua crítica ao enquadramento da natureza pela técnica moderna e também como essa ecofenomenologia se manifesta na reflexão ambiental de forma diversa.
Psicologia e Daseinsanálise: o cuidado em atmosfera filosófica
Authors: MATTAR CRISTINE MONTEIRO
Published: June 2022

O presente artigo apresenta a daseinsanálise como fundamentação filosófica para a psicologia e a prática clínica na atualidade, chamada por Heidegger de era da técnica. Num primeiro momento, mostra-se o quanto as interpretações sedimentadas de mundo se interpõem entre o fenômeno e sua compreensão patologizando-o e judicializando-o, sem nenhuma referência ao horizonte epocal no qual nos movemos. Em seguida, no esforço por interrogar, destruir e esboçar outra resposta ao fato recorre-se à Analítica do Dasein empreendida por Heidegger em Ser e Tempo, bem como às considerações desse filósofo sobre a Daseinsanalyse durante os Seminários de Zollikon, especialmente o nono seminário no qual Heidegger responde às críticas dirigidas à Daseinsanalyse, expõe suas diferentes determinações e marca nitidamente sua discordância da Análise Existencial empreendida por Ludwig Binswanger, a qual considera um equívoco. Ao final, o artigo propõe outra interpretação e aponta caminhos para a clínica psicológica no referencial apresentado.
O Cordel Filosófico de Raimundo: Farias Brito, a Filosofia do Espírito e a Índia
Authors: Loundo Dilip
Published: June 2022

A consolidação da Filosofia do Espírito como Filosofia da Consciência é o centro nevrálgico de um diálogo entre Farias Brito e as tradição filosóficas indianas. Ao invés de uma “influência”, esse encontro sinaliza um caminhar paralelo, solidário e contemporâneo, que dá testemunho de um filosofar original na América Latina. Se, livre das tentações eurocêntricas, a avaliação comparativa da proposta britiana com as filosofias críticas europeias – e.g., o existencialismo, a fenomenologia, a hermenêutica – contribui, por certo, para aclarar aspectos de seu pensamento, por outras tantas razões, a avaliação comparativa com as filosofias dos Upaniṣads e do Budismo pode igualmente trazer aportes inovadores. Um dos aspectos fundamentais desse encontro, é a critica contundente de Farias Brito ao niilismo de Schopenhauer e sua apropriação equivocada das tradições indianas. Num contexto em que a principal fonte de acesso à Índia é o próprio Schopenhauer, a postura crítica de Farias Brito surpreende na adequação à propositividade das filosofias indianas. É, finalmente, em sua Filosofia do Espírito e, em especial, na afirmação de uma razão moral, eminentemente soteriológica, e em conexão estreita com o universo da religião, que percebemos o compromisso de Farias Brito com sua circunstância latino-americana, marcada por teleologias comunitaristas “deste mundo”, que predispõem a uma irmandade civilizacional não-iluminista com a Índia.
A Reversão da Doutrina Copernicana. A arca-originária Terra não se move
Authors: Husserl Edmund
Published: June 2022

Apresentamos aqui a primeira tradução para o português do célebre manuscrito D 17, escrito por Husserl entre 7 e 9 de maio de 1934, e publicado por M. Farber em 1940, no volume Philosophical Essays in Memory of E. Husserl. O manuscrito possuía em seu envelope o seguinte comentário descritivo: "Reversão da doutrina copernicana na interpretação da visão de mundo habitual. A arca-originária Terra não se move. Investigações fundamentais sobre a origem fenomenológica da corporeidade da espacialidade da natureza no sentido primeiro da ciência natural. Todas estas investigações iniciais necessárias". Escrito no estilo livre e vivaz que caracteriza os manuscritos de pesquisa da fenomenologia de Husserl, este texto pertence ao grupo de manuscritos produzidos no entorno da última obra publicada de Husserl, A Crise das Ciências Europeias e a Fenomenologia Transcendental (1936). Se no extensamente comentado §9 desta obra Husserl empreende uma análise da ciência moderna partindo da instituição originária da física de Galilei, o ponto de partida de A Reversão é a noção de natureza que caracteriza o mundo copernicano, a qual estabelece a Terra como um corpo físico situado no interior do universo infinito. A epoché (no sentido específico dado a este termo no interior da fenomenologia husserliana) da tese copernicana leva Husserl à investigação da Terra em uma outra função transcendental, a saber, sua constituição enquanto solo e fundamento de referência para a experiência do espaço, do movimento e do repouso. Ao lado deste primeiro aspecto ligado ao sentido de natureza, a investigação de A Reversão abarca um outro campo temático, onde o manuscrito toca as fronteiras da filosofia fenomenológica e desafia os limites teóricos estabelecidos pelas interpretações ortodoxas da fenomenologia transcendental: a relação entre Terra, historicidade e intersubjetividade. Assim, a parte final do texto é dedicada à exposição da Terra como elemento da "história originária" que vincula todas histórias relativas da humanidade, a qual se organiza em uma multiplicidade de territórios ou moradas. Nos termos de Merleau-Ponty, a Terra é, sob esta perspectiva, a reserva de onde pode provir toda a vida, todo futuro e toda história.Tradução de Gabriel Lago de Sousa Barroso ** Doutor em Filosofia pela Universidade do Estado do Rio de Janeiro (UERJ). Pesquisador associado no Instituto de Filosofia da Universidade de Wuppertal (Alemanha). Pesquisador de pós-doutorado no Arquivo Husserl em Leuven (Bélgica).
O Gênero Teatral Latino: dos Primórdios às Tragédias de Sêneca
Authors: Carneiro. Douglas Castro
Published: June 2022

O objetivo desse artigo é analisar o gênero teatral latino desde suas origens até as tragédias senequianas. Os dramas latinos foram um dos primeiros gêneros literários que se estabeleceram em Roma nos espaços dos festivais públicos e religiosos da sociedade romana.
A plebe romana: análise de sua origem e organização política
Authors: Barros Sidney De Souza
Published: June 2022

Conhecemos a história das origens da plebe romana pelo viés preconceituoso e depreciativo das elites romanas, certamente pautado nos escritos dos membros da aristocracia senatorial e imperial. Pensamento que perdurara na historiografia até praticamente meados do século XIX, quando se começa a indagar as origens e as relações de participação e ascensão política dessa plebe nada ociosa.  Visamos através das próximas linhas, apresentar uma breve análise das origens da plebe romana e das relações de poder estabelecidas nas graduais transformações dos períodos da monarquia e da república romanas como partes de um mesmo processo histórico inclusivo e participativo da plebe romana.
UM “NOVO NORMAL” PARA O NOVO JUDICIÁRIO? Intersecções entre Robinson Crusoé e os diferentes litigantes no acesso à justiça durante (e pós) a Pandemia
Authors: Pedron Flávio , Menezes Rafael , Torres Tiago Henrique
Published: June 2022

Este ensaio busca confrontar os personagens principais do livro Robinson Crusoé, de Daniel Defoe, e os usuários do sistema de justiça, a partir dos dilemas e imposições da Pandemia do Covid-19, que assola a todo o mundo. As particularidades dos personagens Robinson Crusoé e Sexta-Feira, frente à necessidade de readequação a novos modos de vida de forma constante, foram o argumento para a contextualização, já sentida, com as diferenças havidas entre os litigantes habituais e litigantes eventuais no acesso à justiça. A relação entre direito e literatura, nesse caso, buscou lançar luzes sobre os aspectos relacionados à necessidade de readequação dos diferentes litigantes para o acesso pleno à justiça, considerando os impactos da Pandemia sobre a atividade jurisdicional. O método científico empregado na pesquisa foi o indutivo, já que se partiu da análise das particularidades dos personagens e dos diferentes litigantes, como premissas verdadeiras, para se apurar os diferentes modos de readequação às novas realidades por cada, e qual o impacto dessas diferenças sobre o acesso à justiça. Deste modo, foi possível demonstrar que ainda persistem importantes diferenças entre os diferentes litigantes na nova realidade jurisdicional, urgindo a adoção de medidas que reduzam a disparidade.
JURISDIÇÃO NO ESTADO DEMOCRÁTICO DE DIREITO: CRITÉRIOS PARA A TUTELA DA DIGNIDADE DA PESSOA HUMANA SOB A ÓTICA DA HERMENÊUTICA FILOSÓFICA
Authors: Longen do Nascimento Leonardo , Dias Feliciano Alcides
Published: June 2022

O artigo se propõe a analisar a tutela da dignidade da pessoa humana por meio da jurisdição no Estado Democrático de Direito contemporâneo. No desenvolvimento da pesquisa, utilizou-se a pesquisa bibliográfica e documental aliada ao “método” fenomenológico-hermenêutico. A partir de uma revisitação do papel da jurisdição sob a ótica da hermenêutica filosófica, observa-se que esta constitua um juízo autônomo de justiça, que avalia a legitimidade e filtra os discursos que se chocam em um caso concreto a partir da dignidade da pessoa humana, tida como fundamento e finalidade da ordem jurídica.
DIREITO PROCESSUAL COMPARADO, TEORIA GERAL DO PROCESSO E PRECEDENTES
Authors: Mendes Aluisio Gonçalves de Castro , Mendes Carolina Paes de Castro
Published: June 2022

O presente texto trata da relevância do Direito Processual Comparado como ferramenta metodológica de estudos dos institutos processuais e do desenvolvimento do sistema brasileiro de precedentes a partir de características próprias da história, da cultura e das necessidades do país.
LA GESTIÓN MEDIADA DE CONFLICTOS EN EL DERECHO COMUNITARIO EUROPEO Y SU REFLEJO INTERNO: ESTADO DE LA CUESTIÓN Y ESTRATEGIAS DE MEJORA
Authors: Moura Belén Hernández
Published: June 2022

Este trabajo ofrece una foto fija de la situación de la mediación como herramienta adecuada para la gestión de la controversia privada en el marco del Derecho comunitario europeo y cuál sea su reflejo en la normativa española. Junto con el repaso a los precedentes normativos de la Directiva 2008/52/UE y los extremos más relevantes de la misma, se señalan en el trabajo algunos de los factores que, al hilo de los diferentes estudios de implementación, podrían explicar las dificultades que en la práctica encuentra la mediación intrajudicial. Apuntados ya estos condicionantes, el lector podrá identificar las estrategias de mejora promovidas desde la Unión Europa en las proyecciones legislativas españolas más recientes en materia de ADR. Para ello, se ha efectuado una revisión bibliográfica de los autores más relevantes y se han analizado los diferentes documentos de trabajo publicados hasta la fecha por diferentes instituciones europeas. Todo ello para concluir un desarrollo desigual, muy por detrás de lo esperado tras catorce años de vigencia de la Directiva 2008/52/UE y con algunas reformas procesales internas en camino cuya eficacia, pese a las dudas que se plantean en relación a algunos puntos, solo el tiempo podrá determinar.
ATRAPADO POR SU PASADO: ACERCA DE LAS TENSIONES QUE AFECTAN AL RÉGIMEN DE LA PRUEBA EN LOS PROCESOS DE CONSUMO
Authors: Odgers Ramón García , Maureira Claudio Fuentes
Published: June 2022

La prueba constituye un problema común y decisivo en los juicios de consumo, sean estos individuales o colectivos. A pesar de que de manera paulatina se han ido introduciendo diversas reglas y mecanismos probatorios para equilibrar las diferencias entre litigantes, su efectividad ha sido limitada ya que subsiste un contexto normativo, teórico y práctico que tiende a limitar los efectos que tales mecanismos y reglas promueven. Este contexto no ha sido adecuadamente estudiado en el medio Chileno. El objetivo de este texto es dar cuenta de este contexto, los distintos niveles en que opera y las disfuncionalidades que este genera, para posteriormente sugerir algunas bases conceptuales y debatir acerca de algunas propuestas que permitan avanzar en la construcción de un derecho probatorio que se haga cargo de las particularidades de la relación de consumo.La metodología utilizada fue mayoritariamente analítica en cuanto al estudio de las normas, su modificación y también al análisis jurisprudencial.En conclusión, se presentan algunas propuestas para remover obstáculos normativos, teóricos y prácticos para el desarrollo de una actividad judicial en el campo de la prueba más funcional a los objetivos del proceso de consumo. Una primera alternativa sería la elaboración de un código procesal de consumo, que otorgue autonomía teórica y normativa para la tramitación en esta materia. Otra propuesta sería llevar la especialización en esta materia un paso más allá, creando así tribunales dedicados exclusivamente a la resolución de conflictos de consumo. Sin embargo, existe una tercera alternativa que parece más viable y que sería perfectamente compatible con la creación de una legislación completa y coherente, aunque quede en manos de los jueces generales. Tal solución consistiría en introducir la noción de gestión de casos como un vehículo conceptual que viene a modificar y ofrecer nuevos paradigmas sobre la comprensión del papel de los jueces dentro del proceso, cambiando eventualmente la cultura jurídica de los operadores de justicia.
OS PRAZOS PARA INSTAURAÇÃO E ENCERRAMENTO DO INVENTÁRIO SUCESSÓRIO: PONTOS OBRIGATÓRIOS E NERVOSOS SOBRE O TEMA
Authors: Mazzei Rodrigo Reis , Freire Deborah Azevedo
Published: June 2022

O estudo tem como epicentro a interpretação do art. 611 do CPC, que trabalha com os prazos de instauração e encerramento do inventário sucessório. Parte-se da premissa de que, para a correta interpretação do teor normativo do dispositivo, é fundamental que se efetue diálogo da regra nele plasmada com outras normas legais de direito sucessório, inclusive fora do âmbito do CPC. O estudo aponta que há considerável número de questões que sofrem influência do art. 611 do CPC em vigor, sendo ingênuo efetuar sua interpretação isolada, posicionando-o como dispositivo que regula apenas o prazo de instauração e desfecho do inventário sucessório.
AUTORIDADE E LIMITES OBJETIVOS DA COISA JULGADA NO CÓDIGO DE PROCESSO CIVIL BRASILEIRO: UMA ANÁLISE À LUZ DA DOUTRINA CLÁSSICA
Authors: Mazini Paulo Guilherme
Published: June 2022

O presente artigo tem por objeto o estudo da coisa julgada, com o propósito inicial de identificar os conceitos apresentados pelos autores clássicos no direito brasileiro em confronto com a teoria alemã desenvolvida na célebre monografia de Konrad Hellwig. Será analisado, assim, destacadamente, as teorias propostas por Liebman, Barbosa Moreira, Botelho de Mesquita e Ovídio Baptista da Silva. Também será objeto desse estudo a comparação entre os Códigos de Processo Civil de 1973 e o atual quanto aos limites objetivos da coisa julgada e a a sua extensão para as questões prejudiciais, além de propor um debate a respeito da eficácia preclusiva da coisa julgada e a vertente teórica adotada no sistema processual brasileiro. Como uma das principais conclusões, sem prejuízo do que já foi exposto ao final desse artigo, constatou-se a adoção no sistema processual brasileiro da concepção restritiva da eficácia preclusiva da coisa julgada. Para a realização do propósito dessa pesquisa, foi utilizado como metodologia, especialmente, a revisão bibliográfica.
It's time to shift our thinking when it comes to our children with SEND
Authors: Kilgour Stephen
Published: June 2022

Do you have something to share, reflect on or provoke thinking around? Write to the editor: angelica.celinska@markallengroup.com
It's never too early
Authors: Ellyatt Wendy
Published: June 2022

The Sustainable Development Goals (SDGs) were published in 2015 as a way for all countries to achieve a sustainable future. In this article we introduce the SDGs Handbook for the Early Years and suggest that early years settings have a powerful role to play in recognising young children both as important global citizens and future change agents.
An audit of the prescription and supply of medicines by podiatric surgery teams in the UK
Authors: Maher Anthony , Borthwick Alan
Published: June 2022

Aim

To gain a greater understanding of the methods used by podiatric surgeons to access medicines in the UK. Within that, it is also relevant to establish the range and quantity of medicines utilised to support patient care. With the advent of independent prescribing for podiatrists, the authors were keen to identify whether prescribing was being adopted by a sub-speciality of the podiatry profession and whether alternate means of accessing medicines, such as Patient Group Directions or exemptions remain relevant in clinical practice.

Methods

The PASCOM 10 system was accessed to generate reports for the 2019 calendar year relating to podiatric surgery. The following reports were requested; procedures, fixations, anaesthesia, demographics, medications, post-treatment sequelae, patient satisfaction (PSQ-10), Manchester Oxford foot/ankle questionnaire (MOXFQ), providers and referrals.

Results

In 2019 there were 11189 admissions for podiatric surgery in England recorded on the PASCOM 10 database. A total of 103 surgery centres contributed data resulting in 18497 procedures. Care was primarily offered in NHS settings accounting for 91% of activity, 94% of these procedures were performed under a local anaesthetic block. 18576 medicines were supplied, administered or prescribed from a list of 70 individual items. 29% of all medicines were prescribed by a podiatrist. Controlled drugs accounted for 28.7% of all recorded medicines.

Conclusions

Through analysis of PASCOM 10 data, the range of medicines accessed by podiatric surgeons and their teams to support patient care perioperatively and the routes of accessing these medicines have been identified. Encouragingly, independent prescribing appears to be a frequent choice for accessing certain medicines. There is thorough evidence of a need for greater prescribing rights. Of note, it appears the management of postoperative pain could be improved with wider access to controlled drugs, namely opioid analgesics. PASCOM-10 has the capacity to provide revealing data on prescribing in podiatric clinical practice that is unique in the UK, though more work is required to ensure the validity of the dataset.
Give veteran patients the support they need
Authors: Wright Jordana
Published: June 2022

Jordana Wright explains how the free RCGP Veteran Friendly Accreditation Programme can help support the specific health needs of this population
Özel Yetenekli Öğrenciler İle Çalışan Öğretmenlerin Sınıf Yönetimine İlişkin Görüşleri
Authors: BULUT ÖZSEZER M. Sencer , CANBAZOĞLU H. Beyza , TARIM Kamuran
Published: June 2022

Çalışmanın amacı, Bilim ve Sanat Merkezinde görev yapan öğretmenlerin sınıf yönetimine ilişkin görüşlerini belirlemektir. Bu araştırmada, olgubilim deseni kullanılmıştır. Araştırmanın çalışma grubunu, Bilim ve Sanat Merkezinde görev yapan 10 öğretmen oluşturmaktadır. Araştırmanın verileri yarı yapılandırılmış görüşmeler yoluyla toplanmıştır. Verilerin analiz sürecinde içerik analizi yöntemi kullanılmıştır. Öğretmenler, özel yetenekli bireylerin kendilerine has özelliklerine vurgu yaparak onların hareketli, meraklı, yetkin, hırslı olmaları ve örgün eğitimde yaşadıkları uyum sorunları sebebiyle istenmeyen davranışların ortaya çıkabileceğini vurgulamışlardır. Ayrıca Bilim ve Sanat Merkezinde görev yapan öğretmenlerin, özel yetenekli öğrencilerinin istenmeyen davranışlarını yönetme sürecinde kullandıkları stratejiler mesleki ve duyuşsal stratejilerden oluşmaktadır. Bu bağlamda öğretmenlerin kullandıkları stratejiler eğitsel-gelişimsel planlama, teşvik etme, sorumluluk verme, olumlu pekiştirme, yer değiştirme, bireysel özellikleri kabullenme ve görmezden gelme, önlemsel, birebir konuşma kodları altında ele alınmıştır. Elde edilen bulgular doğrultusunda hem hizmet öncesinde hem de hizmet içinde öğretmenlerin özel eğitime yönelik uygulamalı eğitim almaları, öğretmen adaylarının ise özel yetenekli öğrencileri gözlemlemesi ya da bu öğrencilerle deneyim yaşayabilecekleri staj uygulamalarının gerçekleştirilmesi önerilebilir.
Spectrally modulated polarimetry with wavelength domain analysis
Authors: Bendada Hana , Bakhouche Belkacem , González-Siu Luis Oscar , Bruce Neil C. , Arteaga Oriol
Published: June 2022

Spectrally modulated Stokes polarimeters use a pair of high-order crystal retarders to generate a spectrally dependent modulation of the polarization of light. In these systems, the detected intensity versus wavenumber spectrum is usually referred to as a channeled spectrum, and the Fourier inversion of this spectrum allows the determination of Stokes parameters of light without needing any other mechanical or active device for polarization control. This work proposes a spectrally modulated polarimeter beyond the concept of a channeled wavenumber spectrum, so effectively detaching the spectral modulation from the Fourier analysis technique. The wavelength domain analysis we use is best suited for dispersive spectrometers offering intensity versus wavelength measurements. The technique is illustrated with the measurement of very small optical rotations produced by sucrose solutions. The proposed technique is easily extendable to spectrally modulated Mueller polarimeters.
Accurate temperature measurement of cold atoms in cesium fountain clocks
Authors: Medina-Herrera A. , Ortiz C. A. , de Carlos-López E. , López-Romero J. M.
Published: June 2022

We introduce a new approach to determine if a cloud of cold atoms has or not a unique, well-defined temperature. In the first case, the temperature can be determined using the width of the velocity distribution. However, the temperature in a cloud of cold atoms may not be well-defined if the velocity distribution does not turn out to be Gaussian. In this case, the width of the velocity distribution cannot be associated to a unique temperature, and additional considerations exposed here should be followed to measure the temperatures of two groups of atoms forming the whole cloud. Also an uncertainty evaluation is presented.
One-step formation of a plasmonic grating with an ultranarrow resonance linewidth for sensing
Authors: He Zhigang , Kang Guoguo , Wang Junyi , Ding Ning , Chai Yuwei
Published: June 2022

Nanograting-based plasmonic sensors are capable of real-time and label-free detection for biomedical applications. Simple and low-cost manufacturing methods of high-quality sensors are always demanding. In this study, we report on a one-step etch-free method achieved by directly patterning a photoresist on a copper substrate using laser interference lithography. Large area uniform gratings with a period of 600 nm were fabricated on the copper film, and its refractive index sensing performance was tested using glucose as analyte. By replacing the metallic grating ridges with photoresist ridges, the Ohmic absorption and radiative scattering losses of surface plasmons were greatly reduced. As a result, a much sharper resonance linewidth (∼ 10 nm) was experimentally obtained. Compared with pure metallic gratings, the reported structure is characterized by sharper resonance and a much easier fabrication process, making it a cost-effective plasmonic sensor with high quality.
Interaction-free measurements based communication scheme for long-haul data transfer
Authors: Gayen Ankan
Published: June 2022

A communication scheme based on interaction-free measurements is proposed here, that is applicable for long-haul communications. It is shown that the scheme allows the transmitter to transfer real information at the receiver end in a finite amount of time, which is independent of their distance of separation. Now, as the distance of separation increases, effective speed of information transfer increases due to the constant receive-after-time delay. Hence, this communication technique is faster than the conventional way of information transfer at a speed of light, for communications over long distances.