bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in thyroid hormones predict weight regain in patients with obesity who undergo metabolic surgery
Authors: Tang Yi , Liu Wei , Wang Wuhao , Zhao Huandong , Lu Zongshi , Li Qiang , Yan Zhencheng , He Hongbo , Zhao Zhigang , Ke Zhigang , Li Fan , Tong Weidong , Sun Fang , Zhu Zhiming
Published: June 2024

Aim

To investigate the relationship between thyroid function and weight regain in patients with obesity after metabolic surgery.

Methods

This retrospective study enrolled 162 patients who underwent metabolic surgery. Correlations between decreases in thyroid hormone levels and changes in weight, waist circumference (WC) and the Chinese visceral adiposity index (CVAI) were assessed. Binary logistic regression and receiver operating characteristic (ROC) curves were used to identify predictors and clinically useful cut‐off values, respectively.

Results

The levels of thyroid‐stimulating hormone (TSH) and free triiodothyronine (FT3) decreased markedly at 1 year after surgery, as did weight, body mass index (BMI), triglycerides, total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, WC and CVAI. Decreases in TSH and FT3 after metabolic surgery were associated with changes in weight, BMI and CVAI. Binary logistic regression and ROC curve analyses confirmed that decreases in TSH can predict good weight loss after metabolic surgery to some extent. Finally, binary logistic regression and ROC curve analyses confirmed that changes in TSH can predict weight regain after metabolic surgery.

Conclusions

Changes in TSH and FT3 after metabolic surgery were correlated with changes in weight and CVAI. Changes in thyroid hormones can predict weight regain in patients with obesity who underwent metabolic surgery.
The Arab uprising: A decade of transformations and challenges
Authors: Gady Ammar Ahmad Ahmad
Published: June 2024

Motivation

A decade has passed since the outbreak of the so‐called Arab Spring, which led to regime changes in several Arab countries. However, these public protests demonstrated their ineffectiveness in bringing about political and economic improvements, nor did they facilitate a peaceful transition to democracy in Arab countries.

Purpose

This article attempts to discuss the obstacles to democratic transformation in Arab countries and the methods that should be followed to achieve democratic transformation, along with showing the international community's response to the Arab Spring.

Approach and methods

This article relies on a descriptive, methodological, and analytical approach to the obstacles to democratic transformation in Arab countries by analysing the events and results of the Arab Spring.

Findings

The democratic transformation in Arab countries does not require as much concerted effort to protect the right to peaceful assembly as it does to safeguard other rights from violations resulting from certain practices. This is primarily due to significant differences between ideological, intellectual, and political groups within society. Furthermore, democratic transformation in Arab countries necessitates the collective efforts of the international community, particularly Western nations such as the United States, employing a credible and transparent approach free from political or economic interests. These external factors are crucial when it comes to either facilitating or hindering the democratic transition and the implementation of democratic reforms.

Policy implications

The Arab Spring showed that peaceful democratic transitions and the conditions for the continuation or replacement of authoritarian regimes require the approval and support of some countries that are devoid of political or economic interests, as they are external factors that can influence and hinder the democratic transition or ensure democratic reforms. This is especially true because public protests are no longer simply a sign of resistance to the regime but rather are rather a potential advance warning of rebellion and the overthrow of said regimes.
Population life‐history differences and their correlates across a regional spatial scale in largemouth bass (Micropterus nigricans)
Authors: Finigan Rachael E. , Marschall Elizabeth A.
Published: June 2024

Isolation and limited migration among populations and differences in the environments they inhabit set up conditions for population differentiation of life‐history traits, even across a regional spatial scale, such as a statewide landscape of lakes and reservoirs. Our objective was to understand how largemouth bass (Micropterus nigricans) life histories differ across a regional spatial scale (Ohio, USA) and whether environmental differences are influencing this variation. To address this, we (1) described spatial variation in largemouth bass life‐history traits, with a specific interest in potential correlations between early‐life growth and later‐life traits and (2) tested whether life‐history traits can be predicted by reservoir characteristics. We found two groups of correlated population traits: the inverse relationship of early‐life growth rate with population density and asymptotic length and the positive relationship between adult size and asymptotic length. Early‐life growth had a positive relationship (and population density and asymptotic length had a negative relationship) with littoral habitat availability and other environmental conditions expected to enhance early growth. Despite the strong influence of reservoir characteristics on life‐history traits in our analysis, the most plausible model could not give precise predictions of these life‐history traits, suggesting that the availability of data on other aspects of the populations and environments may improve our ability to understand life‐history differences. Overall, our results suggest that, even among recently separated populations, we should expect differences in growth patterns and that we cannot understand drivers of these differences without considering possible correlations in growth patterns across the lifespan.
Fish assemblages on two continents respond to valley‐ and reach‐scale hydrogeomorphic variation: Analyses across three temperate ecoregions
Authors: Pyron Mark , Maasri Alain , Costello John , Kenner Scott , Otgonganbat Amarbat , Mendsaikhan Bud , Chandra Sudeep , Thorp James H. , Arsenault Emily R. , Shields Robert , Artz Caleb , Minder Mario
Published: June 2024

Fish assemblages, defined by taxonomy or functional traits, –respond to regional and local habitat variation. Our hypothesis was that fish assemblages could be best predicted using reach‐scale (RS) hydrology variables over valley‐scale (VS) hydrogeomorphology variables for US and Mongolian rivers. We further predicted that fish traits were predicted better by RS than VS variables. We evaluated the FS and VS hydrogeomorphologies of rivers in the United States and Mongolia in each of three ecoregions: grassland, forest and endorheic. Fishes were collected using a backpack electrofisher, following standard protocols. Constrained ordination analyses were conducted at three scales: among continents, by continents and by individual ecoregions within continents. We found no significant difference in mean variation explained by VS versus RS or by taxonomy versus traits. Ecoregions differed in factors contributing to fish assemblage patterns, likely a result of differences in hydrogeomorphology, hydrological connectivity and historical influences. We found that fish assemblages were structured by hydrogeomorphic processes occurring at VS and RS, and that variables predicting fish assemblages varied with scale and whether fishes were classified by taxonomy or traits. Although anthropogenic impacts were substantially higher for western US rivers than for Mongolian rivers, we were unable to detect strong differences in our ability to predict fish assemblage variation from RS and VS habitat variables.
Fusarium decemcellulare Brick causes root rot of Cinnamomum camphora (Linn) Presl
Authors: Pu Wangling , Hu Yuechen , Wu Tong , Luan Fenggang , Zheng Yongming , Zhou Lifeng , Zhou Xudong
Published: June 2024

Leaf chlorosis and root browning with root rot were observed on mature Cinnamomum camphora (Linn) Presl between 2021 and 2023 in Hangzhou, Zhejiang province, China. Three strains of fungi consistently isolated from the diseased roots were selected for identification and pathogenicity test. They were identified as Fusarium decemcellulare Brick based on the morphology and phylogenetic analysis using combined sequence data. The pathogenicity of the strains was verified by inoculating on C. camphora seedings in pots. Fusarium decemcellulare was reisolated from the artificially inoculated roots of C. camphora seedings. To our knowledge, this is the first report that F. decemcellulare causes root rot on C. camphora worldwide and its potential threat should be monitored.
Improving teacher performance: Evolution and enlightenment of primary and middle school teacher certification institution in China (1978–2023)
Authors: Guo Yanbin
Published: June 2024

From the perspective of historical institutionalism, based on several critical junctures of the past half‐century in China, this paper divides over 40‐year history of China's teacher certification institution into four stages and elaborates on mechanisms and processes of critical junctures that impact even determine teacher certification institution reforms. The features of China's teacher certification institution are as follows: Its examination system is increasingly perfect; its direct accreditation depends more on graduates' quality rather than major categories; its history is a seesaw effect history between pedagogic and academic orientation of teacher education; teacher certification institution and normal specialty students' quality is the bottom line of teacher workforce performance under the open teacher education system; and the intersection between pedagogic and academic orientation of teacher education leads to the standardization and professionalization of teacher education in all respects.
Heterogenous effects of bat declines from white‐nose syndrome on arthropods
Authors: Wray Amy K. , Peery Marcus Z. , Kochanski Jade M. , Pelton Emma , Lindner Daniel L. , Gratton Claudio
Published: June 2024

In North America, white‐nose syndrome (WNS) has caused precipitous declines in hibernating bat populations, raising the question of whether the rapid loss of arthropodivorous bats may affect the abundance of their prey. During the summers of 2015–2018 (1 year after the arrival of WNS in Wisconsin, USA), we performed intensive arthropod black‐light trapping, ultrasonic acoustic monitoring, and emergence counts at 10 little brown (Myotis lucifugus) and big brown (Eptesicus fuscus) bat maternity roosts with paired control sites. For little brown bats, which are severely affected by WNS, roost counts declined by 95% over the four‐year period, compared to a 38% decline in big brown bat roost counts. Total arthropod abundance decreased by 49%, although decreases among common little brown bat prey were less severe. Our natural predator exclusion experiment supports existing evidence that bats can have measurable trophic impacts on arthropod communities, primarily via top‐down effects on common prey.
Dysphagia in primary progressive aphasia: Clinical predictors and neuroanatomical basis
Authors: Mazzeo Salvatore , Mulroy Eoin , Jiang Jessica , Lassi Michael , Johnson Jeremy C. S. , Hardy Chris J. D. , Rohrer Jonathan D. , Warren Jason D. , Volkmer Anna
Published: June 2024

Background and purpose

Dysphagia is an important feature of neurodegenerative diseases and potentially life‐threatening in primary progressive aphasia (PPA) but remains poorly characterized in these syndromes. We hypothesized that dysphagia would be more prevalent in nonfluent/agrammatic variant (nfv)PPA than other PPA syndromes, predicted by accompanying motor features, and associated with atrophy affecting regions implicated in swallowing control.

Methods

In a retrospective case–control study at our tertiary referral centre, we recruited 56 patients with PPA (21 nfvPPA, 22 semantic variant [sv]PPA, 13 logopenic variant [lv]PPA). Using a pro forma based on caregiver surveys and clinical records, we documented dysphagia (present/absent) and associated, potentially predictive clinical, cognitive, and behavioural features. These were used to train a machine learning model. Patients' brain magnetic resonance imaging scans were assessed using voxel‐based morphometry and region‐of‐interest analyses comparing differential atrophy profiles associated with dysphagia presence/absence.

Results

Dysphagia was significantly more prevalent in nfvPPA (43% vs. 5% svPPA and no lvPPA). The machine learning model revealed a hierarchy of features predicting dysphagia in the nfvPPA group, with excellent classification accuracy (90.5%, 95% confidence interval = 77.9–100); the strongest predictor was orofacial apraxia, followed by older age, parkinsonism, more severe behavioural disturbance, and more severe cognitive impairment. Significant grey matter atrophy correlates of dysphagia in nfvPPA were identified in left middle frontal, right superior frontal, and right supramarginal gyri and right caudate.

Conclusions

Dysphagia is a common feature of nfvPPA, linked to underlying corticosubcortical network dysfunction. Clinicians should anticipate this symptom particularly in the context of other motor features and more severe disease.
A collagen biostimulator improves photoaging pigmentation
Authors: Kim Jin Cheol , Kim Dong Chan , Park Hyoung Soo , Seo Suk Bae , Kang Hee Young
Published: June 2024

Photoaging pigmentation conditions such as senile lentigo and melasma show epidermal melanogenic activity and dermal abnormalities, including collagen degradation. A dermal rejuvenation strategy with skin‐lightening therapy directly acting on melanocytes is suggested for photoaging pigmentation. This study investigates whether collagen biostimulation can result in skin lightening of photoaging skin. A split‐face clinical trial was conducted, involving 40 subjects with facial melasma and senile lentigo. Subjects received a poly‐DL‐lactic acid (PDLLA) treatment on one side of their face, whereas the contralateral side received a treatment of normal saline as a control. Assessments were scheduled every month after completing treatments for up to 3 months. Pigmentation was evaluated using the L* value as measured with a chromameter and by investigator global assessment scores (IGA). Subjects reported different outcomes in terms of overall skin quality, including pigmentation, wrinkles and elasticity. Skin biopsies were obtained before the treatment and 4 weeks after completing the treatment. Fontana‐Masson, Masson‐Trichrome and Verhoeff‐van Gieson staining, and fibroblast‐specific protein 1 (FSP1) immunostaining were conducted. The PDLLA treatment demonstrated significant improvements in the L* values and IGA scores from 8 weeks after the subject completed their treatments. These improvements were sustained over a 12‐week assessment period. The subjects reported substantial reductions in both pigmentation and wrinkle severity and elasticity throughout the assessment period. Fontana‐Masson staining showed a marked decrease in pigmentation upon a PDLLA injection compared to the baseline values. Increased immunogenicity of FSP1 and increases in collagen and elastic fibre staining were observed. This study demonstrated remarkable improvements in photoaging pigmentation along with collagen production with a collagen biostimulator. Thus, collagen biostimulators represent a promising therapeutic approach for addressing photoaging signs associated with melasma and senile lentigo. (ClinicalTrials.gov Identifier: NCT05913102).
Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR
Authors: Meyer Olivia Luxford , Andersen Jeppe Dyrberg , Børsting Claus , Morling Niels , Andersen Mikkel Meyer , Wulf Hans Christian , Philipsen Peter Alshede , Lerche Catharina Margrethe
Published: June 2024

Squamous cell carcinoma (SCC) is a common skin cancer, often caused by exposure to ultraviolet radiation (UVR). Recent studies have shown that changes in DNA methylation play a crucial role in the development of cancers. However, methylation patterns of SCC are not well characterised. Identifying biomarkers for the risk of developing SCC could be helpful for early detection and diagnosis and can potentially improve treatment and prevention strategies. This study aimed to investigate methylation changes in the epidermis of mice exposed to UVR for 24 weeks. We examined the DNA methylation levels of 260 199 CpGs using the Illumina Infinium Mouse Methylation BeadChip and studied the epidermis of UVR‐exposed and unexposed mice every 4 weeks for 24 weeks (n = 39). We identified CpGs with large differences in methylation levels (β‐values) between UVR‐exposed and unexposed mice. We also observed differences in the epigenetic age of these mice. We identified CpGs in Rev, Ipmk, Rad51b, Fgfr2, Fgfr3 and Ctnnb1 that may serve as potential biomarkers for SCC risk and could be helpful for the early detection and prevention of SCC. Further investigations are necessary to determine the biological functions and clinical significance of these CpGs.
Deciphering dermatological distinctions: Cornulin as a discriminant biomarker between basal cell carcinoma and squamous cell carcinoma detected through e‐biopsy and machine learning
Authors: Vitkin Edward , Wise Julia , Berl Ariel , Shir‐az Ofir , Kravtsov Vladimir , Yakhini Zohar , Shalom Avshalom , Golberg Alexander
Published: June 2024

Clinical misdiagnosis between cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) poses treatment challenges and carries risks of recurrence, metastases and increased morbidity and mortality. We aimed to identify discriminant proteins markers for cSCC and BCC using a minimally invasive proteome sampling method called e‐biopsy, employing electroporation for non‐thermal cell permeabilization and machine learning. E‐biopsy facilitated ex vivo proteome extraction from 21 cSCC and 21 BCC pathologically validated human cancers. LC/MS/MS profiling of 126 proteomes was followed by machine learning analysis to identify proteins distinguishing cSCC from BCC. For identified panel validation, we used proteomes sampled by e‐biopsy from unrelated 20 cSCC and 46 BCC human cancers, and differential expression analysis of published transcriptomics. Cornulin, the most commonly chosen discriminative biomarker by machine learning models, was also validated using fluorescent immunohistochemistry. One hundred and ninety‐two proteomes sampled from one hundred eight patients were analysed. Machine learning‐based approaches resulted in a set of 11 potential biomarker proteins that can be used to construct a patient classification model with 95.2% average cross‐validation accuracy, BCC precision of 93.6 ± 14.5%, cSCC precision of 98.4 ± 7.2%, specificity of 97.7 ± 11.8% and sensitivity 92.7 ± 15.3%. Protein–protein interaction analysis revealed a novel interaction network connecting 10 of the 11 resulted proteins. Histological and transcriptomic validation confirmed cornulin as a discriminant marker significantly lower in cSCC than in BCC. E‐biopsy combined with machine learning provides a novel approach to molecular sampling from skin for biomarker detection and differential expression analysis between cSCC and BCC.
Very high cycle fatigue of fiber‐reinforced polymer composites: Uniaxial ultrasonic fatigue
Authors: Behvar Alireza , Sojoodi Mahyar , Elahinia Mohammad , Niutta Carlo B. , Tridello Andrea , Paolino Davide S. , Haghshenas Meysam
Published: June 2024

This review explores uniaxial ultrasonic fatigue (USF) testing as a common and dependable method for quantifying the extended fatigue life of fiber‐reinforced polymer (FRP) composites. The objective is to explain the complexities governing the fatigue life behavior of FRPs, particularly in the realm of very high cycle fatigue (VHCF) where the number of loading cycles exceeds 107. To this end, this review encompasses the analysis of VHCF behavior, including the derivation and interpretation of stress–life (S–N) data, the evaluation of various fatigue damage mechanisms (i.e., controlling mechanisms of crack initiation and propagation) exhibited in FRP composites, and a thorough investigation of the frequency‐dependent effects on fatigue responses. Furthermore, this review tries to analyze the microscopic intricacies intrinsic to the VHCF failure of FRP composites, encompassing aspects such as fiber‐matrix de‐bonding, matrix cracking, and delamination, unveiling their modes and effects in a detailed manner. This review also underscores the pivotal integration of simulations, machine learning, and modeling techniques, emphasizing their crucial role in explaining both macroscopic and microscopic interactions governing the VHCF of FRPs.
Unveiling interconnectedness between marine protected and non‐protected areas in Tanzania: Insights from barred mudskipper (Periophthalmus argentilineatus) population genetic structure
Authors: Rumisha Cyrus
Published: June 2024

Marine protected areas (MPAs) are globally recognised for their role in safeguarding marine fisheries from the detrimental impacts of human activities and climate change. Tanzania, in alignment with global conservation efforts, has designated 18 MPAs and plans to establish four more in the Southwestern Indian Ocean. However, a critical challenge arises from the lack of a thorough understanding of genetic connectivity between populations in MPAs and non‐protected areas (NPAs). To address this, 151 mitochondrial D‐loop sequences (357 base pairs) of Barred mudskipper (Periophthalmus argentilineatus) were analysed to assess genetic connectivity between MPAs and NPAs in Tanzania. The findings revealed a low and insignificant index of genetic differentiation (FST = −0.0046, p > 0.05) between populations in MPAs and NPAs. Furthermore, haplotypes from both MPAs and NPAs did not cluster based on their geographical origins, with over 9 haplotypes shared between these areas. Additionally, the measured haplotype and nucleotide diversities did not differ significantly between MPAs and NPAs (p > 0.05). However, MPAs showed a significantly higher number of private haplotypes compared to NPAs (p < 0.05). These findings suggest high genetic interconnectedness between populations in MPAs and NPAs, underlining the importance of existing MPAs in preserving local genetic diversity and their potential to replenish depleted NPAs. However, realising the full potential of this interconnectedness necessitates stringent enforcement of sustainable fishing practices to alleviate pressure on fish stocks. It also requires the protection of critical habitats that serve as corridors for fish dispersal, facilitating interconnectedness between MPAs and NPAs.
A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast
Authors: Ohtsuka Hokuto , Ohara Kotaro , Shimasaki Takafumi , Hatta Yoshiko , Maekawa Yasukichi , Aiba Hirofumi
Published: June 2024

In the fission yeast Schizosaccharomyces pombe, the response to sulfur depletion has been less studied compared to the response to nitrogen depletion. Our study reveals that the fission yeast gene, SPCC417.09c, plays a significant role in the sulfur depletion response. This gene encodes a protein with a Zn2Cys6 fungal‐type DNA‐binding domain and a transcription factor domain, and we have named it sdr1+ (sulfur depletion response 1). Interestingly, while sulfur depletion typically induces autophagy akin to nitrogen depletion, we found that autophagy was not induced under sulfur depletion in the absence of sdr1+. This suggests that sdr1+ is necessary for the induction of autophagy under conditions of sulfur depletion. Although sdr1+ is not essential for the growth of fission yeast, its overexpression, driven by the nmt1 promoter, inhibits growth. This implies that Sdr1 may possess cell growth‐inhibitory capabilities. In addition, our analysis of Δsdr1 cells revealed that sdr1+ also plays a role in regulating the expression of genes associated with the phosphate depletion response. In conclusion, our study introduces Sdr1 as a novel transcription factor that contributes to an appropriate cellular nutrient starvation response. It does so by inhibiting inappropriate cell growth and inducing autophagy in response to sulfur depletion.
Subjectivities of highly skilled lead, tied, and equal migrant mothers
Authors: Kačkutė Eglė
Published: June 2024

Professionally mobile individuals tend to migrate for career purposes at the prime age of reproduction. This article focuses on highly skilled migrant mothers from different cultural backgrounds living and working in Geneva. The article argues that they inhabit and internalize their identities as―lead, tied, and/or equal―migrants and this impacts ways in which they come to develop their professional and maternal subjectivities. Highly skilled migrant mothers who identified with their tied migrant status developed a neoliberal professional and maternal subjectivity, whereas those who had internalized the lead or equal migrant ideal subjectivities developed liberal feminist professional and maternal selves. The typology of postfeminist/neoliberal versus liberal feminist migrant mothers' subjectivities helps us to better understand the feminist potentials for migration of highly skilled mothers.
Eradication Therapy for Helicobacter pylori Infection in Patients Receiving Hemodialysis: Review
Authors: Sahara Shu , Sugimoto Mitsushige , Murata Masaki , Iwata Eri , Kawai Takashi , Murakami Kazunari , Yamaoka Yoshio , Shimoyama Tadashi
Published: June 2024

Patients receiving hemodialysis (HD) often develop gastrointestinal diseases. Recently, although in general population, clinical guidelines for Helicobacter pylori have strongly recommended its eradication in patients to prevent gastric cancer, optimal eradication regimen and optimal dosage of drugs for patients receiving HD have not been established, due to possible incidence of adverse events. Some antimicrobial agents used in eradication therapy, particularly amoxicillin, can exacerbate renal dysfunction. Given the delayed pharmacokinetics of drugs in patients receiving HD compared with those in healthy individuals, drug regimen and dosage should be considered to minimize adverse effects. Although previous studies have investigated the benefits of eradication therapy for patients receiving HD, because most studies were small in terms of the number of enrolled patients, it is hard to show evidence. The numbers of eradication in HD patients have recently increased, and it is important to provide an optimal regimen. The consideration of eradication in patients undergoing HD with a reduction in the drug dose by 1/2–1/3 may prevent adverse events. Additionally, another important consideration is whether adverse events can be prevented while maintaining a similar eradication rate with reduced drug dosages. Recent meta‐analysis findings indicate comparable eradication rates in patients receiving HD and healthy individuals, both with the same dosage regimen and at a reduced dosage regimen, with no significant differences (relative risk [RR] for successful eradication: 0.85 [95% confidence interval (CI): 0.48–1.50]). Unlike with the same dosage regimen (RR for adverse events: 3.15 [95% CI: 1.93–5.13]), the adverse events in the dosage reduction regimen were similar to those in healthy individuals (RR: 1.26 [95% CI: 0.23–6.99]). From a pharmacological perspective, the eradication regimen in patients receiving HD should consider the dosage (1/2–1/3 dosage), dosing number (bid), dosing timing of drugs (after HD), and susceptibility to antimicrobial agents.
Changes in alanine aminotransferase and body composition and metabolic factors among individuals receiving medical health checkups
Authors: Onishi Saori , Fukuda Akira , Matsui Masahiro , Ushiro Kosuke , Nishikawa Tomohiro , Asai Akira , Kim Soo Ki , Nishikawa Hiroki
Published: June 2024

Aim

To examine the relationship between changes in alanine aminotransferase (ALT) and those in body composition and metabolic factors in participants receiving medical health checkups (4350 men [mean age 52.5 years] and 5398 women [mean age 50.5 years])

Methods

We divided the participants into four types based on their ALT value at baseline and 1 year: A, ALT ≤30 (baseline) and ≤30 (1 year); B, ALT ≥31 (baseline) and ≤30 (1 year); C, ALT ≤30 (baseline) and ≥31 (1 year); and D, ALT ≥31 (baseline) and ≥31 (1 year). The change in each body composition‐related parameter (waist circumference, fat mass, fat‐free mass, fat mass to fat‐free mass ratio, etc.) after 1‐year was defined as Δ.

Results

The mean changes in waist circumference (cm) in the four types (A, B, C, and D) were −0.33, −1.54, 0.66, and −0.29 (overall p < 0.0001) in men, and −0.19, −0.90, 0.30, and 0.090 (overall p < 0.0001) in women. The mean changes in fat mass (kg) in the four types were −0.027, −0.86, 0.62, and 0.092 (overall p < 0.0001) in men, and 0.0067, −0.48, 0.39, and 0.063 (overall p < 0.0001) in women. The mean changes in fat‐free mass (kg) in the four types were −0.028, −0.55, 0.42, and −0.034 (overall p < 0.0001) in men, and −0.0091, −0.34, 0.12, and −0.045 (overall p = 0.0012) in women. The mean changes in fat mass to fat‐free mass ratio in the four types were −0.00042, −0.0120, 0.00837, and 0.00171 (overall p < 0.0001) in men, and −0.00013, −0.00817, 0.00730, and 0.00628 (overall p < 0.0001) in women.

Conclusion

A decrease in ALT to ≤30 IU/L may be associated with improved body composition balance, but caution should be exercised for the decrease in muscle mass.
The psychosocial impact of a chronic disease in Ireland: Burdens and helpful practices for a life with epidermolysis bullosa
Authors: Salamon Gudrun , Field‐Werners Ursula , Strobl Sophie , Hübl Vinzenz , Diem Anja
Published: June 2024

Objective

Although Ireland has one of the highest levels of well‐being in Europe, having a health condition has been found to have a direct negative impact. The aim of this study is to evaluate the current situation and the experiences of patients with epidermolysis bullosa (EB), a rare genetic skin disease, and their relatives living in Ireland, with a focus on burdens and helpful practices.

Methods and Measures

In a mixed‐methods design, a series of standardised questionnaires were combined with open‐ended questions. Via an online survey, data from n = 59 EB patients and relatives of EB patients living in Ireland were collected.

Results

EB affects both the patients and their relatives. Burdens were found in relation to the visibility of EB, the degree of severity, the current health status, reduced mobility, the financial impact of EB, the psychosocial impact and personal and social resources. The paper also analyses existing resources and highlights opportunities for support and needs of improvement.

Conclusion

Quality of life with EB is influenced by somatic symptoms and the psychosocial burden. Individual helpful practices in dealing with this rare disease can be considered as mediators, but they need to be supported by structural and healthcare improvements.

Patient or Public Contribution

The perspective of EB patients, their relatives and EB experts were taken into account in the development of the study design via two feedback loops with the EB patient organisations DEBRA Ireland and DEBRA Austria. The design was adapted accordingly. Additionally, by including open‐ended questions, patients and relatives could contribute their individual perspectives and add insights into their lives with EB that might not have been captured with the structured online survey alone.
Extensive mismatch between protected areas and biodiversity hotspots of Iranian Lepidoptera
Authors: Noori Sajad , Rödder Dennis , Soofi Mahmood , Hawlitschek Oliver , Husemann Martin , Rajaei Hossein
Published: June 2024

Amidst the era of rapid decline in insect diversity, the role of protected areas (PAs) in conserving current insect diversity is more significant than ever. Previous studies indicate that the species‐diverse regions in Iran fall within two global biodiversity hotspots (GBHs): the Irano‐Anatolian hotspot in the north and the Caucasus hotspot in the west. However, there is an extensive conservation gap between species‐diverse regions and PAs for different vertebrate taxa. Additionally, mega‐diverse groups of insects have been overlooked in previous conservation assessments.

In this study, using the most comprehensive occurrence dataset of 1974 species from nine families of Lepidoptera, we delineated regions with statistically significant high diversity as diversity hotspots of the group. Furthermore, we defined the regions with higher conservation priority. Finally, we applied a gap analysis to assess the mismatch between the network of PAs and the most species‐diverse regions.

Most species‐diverse regions of Lepidoptera fall within GBHs and particularly the Irano‐Anatolian hotspot. Overall, the results of our gap analysis revealed that less than one quarter of currently established PAs cover priority areas for conservation, which indicates a dramatic deficiency of the network of PAs in conserving higher priority areas of Lepidoptera.

Misplacement of the PAs in Iran, beside pressure of human footprint, can reduce the effectiveness of the established PAs to conserve the current biodiversity. Hence, enhancing the existing network of PAs and designing new ones, while considering mega‐diverse taxa such as insects, will be essential for implementing effective conservation practices.
Microstructure and mechanical properties of Al2O3 ceramic and copper joints brazed with AgCuInTi brazing alloy
Authors: Li Botao , Liu Ben , Wang Yong , Hu Ruoqi , Wang Ying , Yang Zhenwen
Published: June 2024

Reliable metallurgical bonding between Al2O3 ceramic and copper was achieved by vacuum brazing using Ag–23Cu–14.5In–3.3Ti (wt.%) alloy. The representative interfacial structure of the joint was Al2O3/Ti3(Cu,Al)3O + γ‐TiO/Ag‐based solid solution + (Cu,Ag)7In3 + Ag–Cu eutectic + Cu‐based solid solution/copper. The interface microstructure evolved with process parameters, including the formation of γ‐TiO and Ti3(Cu,Al)3O, as evidenced by microstructural analysis and etched surface morphology. The relationship between fracture path and shear strength was established by observing the fracture morphology and performing shear strength tests on joints with various process parameters, utilizing the degree of the Ag‐based solid solution loss and the thickness of the reaction layer as evaluative factors. When brazed at 760 or 780°C for 20 min using a 100 µm brazing alloy foil, the brazed joints demonstrated a peak shear strength of 215 ± 25 MPa, and the fracture predominantly occurred in the Al2O3 matrix and Ti3(Cu,Al)3O layer.
Barriers and Enablers for Adolescents Accessing Substance‐Use Treatment: A Systematic Review and Narrative Synthesis
Authors: James Philip D. , Nash Michael , Comiskey Catherine M.
Published: June 2024

Substance use is a persistent concern for adolescents in many countries due to the significant negative impact on mental, physical and social outcomes. US research indicates that while 4.1% of 12–17‐year‐olds require treatment, <10% of those who require it access it. This paper summarises the literature available on the barriers and enablers to those under 18s attending substance use treatment to inform policy and practice. Using a systematic approach, we searched six databases for studies which reported barriers and enablers to those aged 18 and under accessing substance use treatment. Thirty‐two papers met the inclusion criteria and we present the findings using a narrative synthesis. Only one paper identified explored this topic in Europe. Barriers and enablers are presented across four themes: (1) individual factors, (2) societal factors, (3) Gateway Providers and (4) treatment service factors. Mental health nurses, especially those working with young people, should be aware that adolescents are unlikely to perceive their substance use as problematic and rely on adults to access treatment. Access appears more difficult for females and socially marginalised youth. Various professionals direct young people towards treatment, but clear protocols are needed to encourage them to intervene, which could be an opportunity for nurses to be innovative and lead in this area. Services perceived as adolescent‐specific, youth‐friendly and flexible encourage attendance while the cost of treatment, including time off work and transport, function as barriers.
The long cultural backlash movement: Pro‐regime social justice mobilizations, discourses and policies in Iran (1995–2010)
Authors: Teimouri Amirhossein
Published: June 2024

Growing research on state‐organized mobilizations (SOMs) has yet to establish a clear connection between cultural backlash movements in authoritarian regimes and a broad range of state‐led contentions, especially SOMs. The case of SOMs in the Islamic Republic of Iran (IR), exemplified by cultural backlash from 1995 until 2010, considerably enriches our understanding of various forms of state‐led contentions. Pro‐regime cultural contentions in Iran also give insights into how states upgrade their actions and rhetorical repertoires in response to a wide variety of perceived and real threats. Drawing on a unique longitudinal newspaper data set and analysing street rallies, policies and rhetoric of pro‐regime actors and factions, I show how culturally motivated social justice contentions by revolutionary rightist (RR) groups in Iran evolved into a long cultural movement, giving rise to a new type of SOMs – theorized as proactive performative ideological mobilizations – in the context of the IR. Further, this long cultural movement paved the way for Mahmoud Ahmadinejad's ascent to power in 2005, resulting in salient policy outcomes. Moreover, my findings suggest that pro‐regime RR actors exercise their agency by not only countering anti‐regime contentions but also by challenging the IR's various governing bodies. Finally, I propose that SOMs should be understood as enduring cultural movements in order to better make sense of their emergence and material consequences.
Self‐management to prevent recurrence in venous leg ulcers: A concept analysis
Authors: Pennisi Yvonne , Müller Nicole , Buckley Claire , Hartigan Irene , Murphy Siobhan
Published: June 2024

The recurrence of venous leg ulcers (VLUs) is of concern to both patients and health care systems, with large amounts of resources being consumed by this chronic condition. Self‐management has been recommended to decrease the recurrence of VLUs. However, this concept has not been clearly defined in VLU recurrence prevention. The aim of this concept analysis was to describe self‐management in VLU recurrence prevention, and explore the terms used and their application in preventing VLU recurrence. Using Walker and Avant's method of concept analysis, 19 articles were systematically reviewed. The primary term used was that of self‐care. The defining attributes included (a) completing preventative tasks of compression, elevation and exercise; (b) lifelong compliance with preventative tasks by patients; (c) internal factors of understanding why tasks are needed, and motivation/belief they will help prevent recurrence, hence changing routines/lifestyles; (d) environmental support through local health care systems and support systems, while avoiding risk. Inconsistent terminology use can cause communication issues within wound management as well as multidisciplinary teams. Although self‐management is evolving, its development may have been constrained by the medical model, which emphasises compliance with direct preventative tasks for this chronic condition. There is minimal focus on external or environmental factors that support behaviour change. The use of the term self‐management may be more beneficial to communication between professions as it aligns with the chronic disease research. Presently the concept focuses on concordance of the patient with completing the preventative tasks of lifelong compression, elevation and exercise/mobility. The person's beliefs and understanding that compliance with these tasks will reduce the risk of recurrence, and hence, lifelong changes to routines, habits and lifestyles must be made by the person.
Small non‐coding RNA signatures in atrial appendages of patients with atrial fibrillation
Authors: Zeng Yuhong , Yuan Zhiquan , Li Jun , Yang Lanqing , Li Chengying , Xiang Ying , Wu Long , Xia Tingting , Zhong Li , Li Yafei , Wu Na
Published: June 2024

The development of high‐throughput technologies has enhanced our understanding of small non‐coding RNAs (sncRNAs) and their crucial roles in various diseases, including atrial fibrillation (AF). This study aimed to systematically delineate sncRNA profiles in AF patients. PANDORA‐sequencing was used to examine the sncRNA profiles of atrial appendage tissues from AF and non‐AF patients. Differentially expressed sncRNAs were identified using the R package DEGseq 2 with a fold change >2 and p < 0.05. The target genes of the differentially expressed sncRNAs were predicted using MiRanda and RNAhybrid. Gene Ontology (GO) categories and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed. In AF patients, the most abundant sncRNAs were ribosomal RNA‐derived small RNAs (rsRNAs), followed by transfer RNA‐derived small RNAs (tsRNAs), and microRNAs (miRNAs). Compared with non‐AF patients, 656 rsRNAs, 45 miRNAs, 191 tsRNAs and 51 small nucleolar RNAs (snoRNAs) were differentially expressed in AF patients, whereas no significantly differentially expressed piwi‐interacting RNAs were identified. Two out of three tsRNAs were confirmed to be upregulated in AF patients by quantitative reverse transcriptase polymerase chain reaction, and higher plasma levels of tsRNA 5006c‐LysCTT were associated with a 2.55‐fold increased risk of all‐cause death in AF patients (hazard ratio: 2.55; 95% confidence interval, 1.56–4.17; p < 0.001). Combined with our previous transcriptome sequencing results, 32 miRNA, 31 snoRNA, 110 nucleus‐encoded tsRNA, and 33 mitochondria‐encoded tsRNA target genes were dysregulated in AF patients. GO and KEGG analyses revealed enrichment of differentially expressed sncRNA target genes in AF‐related pathways, including the ‘calcium signaling pathway’ and ‘adrenergic signaling in cardiomyocytes.’ The dysregulated sncRNA profiles in AF patients suggest their potential regulatory roles in AF pathogenesis. Further research is needed to investigate the specific mechanisms of sncRNAs in the development of AF and to explore potential biomarkers for AF treatment and prognosis.
Dermatological emergencies and determinants of hospitalization in Switzerland: A retrospective study
Authors: Cazzaniga S. , Heidemeyer K. , Zahn C. A. , Seyed Jafari S. M. , Sauter T. C. , Naldi L. , Borradori L.
Published: June 2024

Background

Dermatologic conditions are estimated to account worldwide for approximately 8% of all visits at emergency departments (EDs). Although rarely life‐threatening, several dermatologic emergencies may have a high morbidity. Little is known about ED consultations of patients with dermatological emergencies and their subsequent hospital disposal.

Objective

We explore determinants and clinical variables affecting patients' disposal and hospitalization of people attending the ED at a Swiss University Hospital, over a 56‐month observational period, for a dermatological problem.

Methods

De‐identified patients' information was extracted from the hospital electronic medical record system. Generalized estimating equations were used to explore determinants of patient's disposition.

Results

Out of 5096 consecutive patients with a dermatological main problem evaluated at the ED, 79% of patients were hospitalized after initial assessment. In multivariable analyses, factors which were significantly associated with an increased admission rate included length of ED stay, age ≥ 45 years, male sex, distinct vital signs, high body mass index, low oxygen saturation, admission time in the ED and number and type of dermatological diagnoses. Only 2.2% of the hospitalized patients were admitted to a dermatology ward, despite the fact that they had dermatological diagnoses critically determining the diagnostic related group (DRG) payment. The number of patients managed by dermatologists during in‐patient treatment significantly decreased over the study period.

Conclusions

Our study identifies a number of independent predictors affecting the risk of hospital admission for patients with dermatological conditions, which may be useful to improve patients' disposal in EDs. The results indicate that the dermatological specialty is becoming increasingly marginalized in the management of patients in the Swiss hospital setting. This trend may have significant implications for the delivery of adequate medical care, outcomes and cost‐effectiveness. Dermatologists should be more engaged to better position their specialty and to effectively collaborate with nondermatologists to enhance patient care.
Effect of titanium dioxide nanoparticle (TiO2‐NP) exposure in a novel Amur sturgeon Acipenser schrenckii hepatocyte cell line
Authors: Zhou Zhou , Liu Ting , Luo Tianxun , Zhao Zhenxing , Zhu Junquan
Published: June 2024

In vitro cell culture is crucial for predicting the toxicity of titanium dioxide nanoparticle (TiO2‐NP). However, assessing the toxicity of TiO2‐NPs in sturgeon remains difficult given the lack of sufficient cell lines. We established and characterized the first hepatocyte cell line from Acipenser schrenckii liver tissue (ASL). This ASL cell line proliferated well in Dulbecco's modified Eagle's medium at 25°C and 10% fetal bovine serum. ASL cells with a chromosome number of 244 were successfully transfected with the pEGFP‐N3 plasmid. The ASL cell line's origin was verified as A. schrenckii through mitochondrial cytochrome C oxidase I and mitochondrial 16S ribosomal RNA (rRNA) sequencing. Using the ASL cell line as an in vitro model, we found that TiO2‐NP exposure decreased the viability and promoted the damage of ASL cells (96‐h LC50 = 331.8 μg mL−1). Increased reactive oxygen species and malondialdehyde levels in ASL cells suggested oxidative stress under TiO2‐NP exposure. We also observed dysregulation of aspartate aminotransferase and alanine aminotransferase levels. By detecting calcium ions and mitochondrial membrane potential indicators, we found that the apoptotic pathway induced by endoplasmic reticulum stress played a major role at low concentrations of TiO2‐NP‐induced stress. Both mitochondria‐mediated and endoplasmic reticulum stress promoted apoptosis under increasing TiO2‐NP concentrations. In conclusion, the ASL cell line established in this study is a useful in vitro model for toxicological studies of TiO2‐NP exposure in fish.
Relationship between Helicobacter pylori infection, osteoporosis, and fracture
Authors: Tan Jing Tong , Cheung Ching Lung , Cheung Ka Shing
Published: June 2024

Osteoporotic fracture is a prevalent noncommunicable disease globally, causing significant mortality, morbidity, and disability. As the population ages, the healthcare and economic burden of osteoporotic fracture is expected to increase further. Due to its multifactorial features, the development of osteoporotic fracture involves a complex interplay of multiple risk factors, including genetic, environmental, and lifestyle factors. Helicobacter pylori, which infects approximately 43% of the world's population, has been associated with increased fracture risk due to hypochlorhydria from atrophic gastritis and systemic inflammation from elevated pro‐inflammatory cytokines. However, the potential impact of H. pylori infection and eradication on fracture risk remains contentious among various studies due to the study design and inadequate adjustment of confounding factors including baseline gastritis phenotype. In this review, we provided a comprehensive evaluation of the current evidence focusing on the underlying mechanisms and clinical evidence of the association between H. pylori infection and osteoporotic fracture. We also discussed the potential benefits of H. pylori eradication on fracture risk.