bluuebunny/crossref_metadata_2025 huggingface dataset:
Beta-Blockers as an Immunologic and Autonomic Manipulator in Critically Ill Patients: A Review of the Recent Literature
Authors: Eraky Akram M. , Yerramalla Yashwanth , Khan Adnan , Mokhtar Yasser , Alamrosy Mostafa , Farag Amr , Wright Alisha , Grounds Matthew , Gregorich Nicole M.
Published: July 2024

The autonomic nervous system plays a key role in maintaining body hemostasis through both the sympathetic and parasympathetic nervous systems. Sympathetic overstimulation as a reflex to multiple pathologies, such as septic shock, brain injury, cardiogenic shock, and cardiac arrest, could be harmful and lead to autonomic and immunologic dysfunction. The continuous stimulation of the beta receptors on immune cells has an inhibitory effect on these cells and may lead to immunologic dysfunction through enhancing the production of anti-inflammatory cytokines, such as interleukin-10 (IL-10), and inhibiting the production of pro-inflammatory factors, such as interleukin-1B IL-1B and tissue necrotizing factor-alpha (TNF-alpha). Sympathetic overstimulation-induced autonomic dysfunction may also happen due to adrenergic receptor insensitivity or downregulation. Administering anti-adrenergic medication, such as beta-blockers, is a promising treatment to compensate against the undesired effects of adrenergic surge. Despite many misconceptions about beta-blockers, beta-blockers have shown a promising effect in decreasing mortality in patients with critical illness. In this review, we summarize the recently published articles that have discussed using beta-blockers as a promising treatment to decrease mortality in critically ill patients, such as patients with septic shock, traumatic brain injury, cardiogenic shock, acute decompensated heart failure, and electrical storm. We also discuss the potential pathophysiology of beta-blockers in various types of critical illness. More clinical trials are encouraged to evaluate the safety and effectiveness of beta-blockers in improving mortality among critically ill patients.
Amelioration of Photoreceptor Degeneration by Intravitreal Transplantation of Retinal Progenitor Cells in Rats
Authors: Yang Jing , Lewis Geoffrey P. , Hsiang Chin-Hui , Menges Steven , Luna Gabriel , Cho William , Turovets Nikolay , Fisher Steven K. , Klassen Henry
Published: July 2024

Photoreceptor degeneration is a major cause of untreatable blindness worldwide and has recently been targeted by emerging technologies, including cell- and gene-based therapies. Cell types of neural lineage have shown promise for replacing either photoreceptors or retinal pigment epithelial cells following delivery to the subretinal space, while cells of bone marrow lineage have been tested for retinal trophic effects following delivery to the vitreous cavity. Here we explore an alternate approach in which cells from the immature neural retinal are delivered to the vitreous cavity with the goal of providing trophic support for degenerating photoreceptors. Rat and human retinal progenitor cells were transplanted to the vitreous of rats with a well-studied photoreceptor dystrophy, resulting in substantial anatomical preservation and functional rescue of vision. This work provides scientific proof-of-principle for a novel therapeutic approach to photoreceptor degeneration that is currently being evaluated in clinical trials.
Identification of the Key Gene DfCCoAOMT1 through Comparative Analysis of Lignification in Dendrocalamus farinosus XK4 and ZPX Bamboo Shoots during Cold Storage
Authors: Zhao Xin , Song Wenjuan , Chen Sen , Xu Gang , Long Zhijian , Yang Heyi , Cao Ying , Hu Shanglian
Published: July 2024

Dendrocalamus farinosus bamboo shoots, a species with rich nutritional value, are important in Southwest China. Lignin is an important factor affecting the postharvest flavor quality of bamboo shoots; however, the underlying mechanism of lignin deposition in D. farinosus bamboo shoots during cold storage is still not fully understood. In this study, the mutant D. farinosus XK4 with low lignin content at 3.11% and the cultivated variety ZPX at 4.47% were used as experimental materials. The lignin content of D. farinosus XK4 and ZPX, as well as the gene expression differences between them, were compared and analyzed during cold storage using transcriptomic and physiological methods. Our analysis revealed several key genes and found that D. farinosus CCoAOMT1 plays a key role in the regulatory network of bamboo shoots during cold storage. Tobacco heterologous transformation experiments demonstrated that overexpression of DfCCoAOMT1 significantly increases lignin content. This study provides a novel foundation for future research aimed at improving the postharvest quality and flavor of D. farinosus bamboo shoots through targeted genetic manipulation during cold storage.
Crosstalk among WEE1 Kinase, AKT, and GSK3 in Nav1.2 Channelosome Regulation
Authors: Singh Aditya K. , Singh Jully , Goode Nana A. , Laezza Fernanda
Published: July 2024

The signaling complex around voltage-gated sodium (Nav) channels includes accessory proteins and kinases crucial for regulating neuronal firing. Previous studies showed that one such kinase, WEE1—critical to the cell cycle—selectively modulates Nav1.2 channel activity through the accessory protein fibroblast growth factor 14 (FGF14). Here, we tested whether WEE1 exhibits crosstalk with the AKT/GSK3 kinase pathway for coordinated regulation of FGF14/Nav1.2 channel complex assembly and function. Using the in-cell split luciferase complementation assay (LCA), we found that the WEE1 inhibitor II and GSK3 inhibitor XIII reduce the FGF14/Nav1.2 complex formation, while the AKT inhibitor triciribine increases it. However, combining WEE1 inhibitor II with either one of the other two inhibitors abolished its effect on the FGF14/Nav1.2 complex formation. Whole-cell voltage-clamp recordings of sodium currents (INa) in HEK293 cells co-expressing Nav1.2 channels and FGF14-GFP showed that WEE1 inhibitor II significantly suppresses peak INa density, both alone and in the presence of triciribine or GSK3 inhibitor XIII, despite the latter inhibitor’s opposite effects on INa. Additionally, WEE1 inhibitor II slowed the tau of fast inactivation and caused depolarizing shifts in the voltage dependence of activation and inactivation. These phenotypes either prevailed or were additive when combined with triciribine but were outcompeted when both WEE1 inhibitor II and GSK3 inhibitor XIII were present. Concerted regulation by WEE1 inhibitor II, triciribine, and GSK3 inhibitor XIII was also observed in long-term inactivation and use dependency of Nav1.2 currents. Overall, these findings suggest a complex role for WEE1 kinase—in concert with the AKT/GSK3 pathway—in regulating the Nav1.2 channelosome.
Caprylic Acid Inhibits High Mobility Group Box-1-Induced Mitochondrial Damage in Myocardial Tubes
Authors: Nukaga Shota , Fujiwara-Tani Rina , Nishida Ryoichi , Miyagawa Yoshihiro , Goto Kei , Kawahara Isao , Nakashima Chie , Fujii Kiyomu , Ogata Ruiko , Ohmori Hitoshi , Kuniyasu Hiroki
Published: July 2024

Myocardial damage significantly impacts the prognosis of patients with cancer; however, the mechanisms of myocardial damage induced by cancer and its treatment remain unknown. We previously reported that medium-chain fatty acids (MCFAs) improve cancer-induced myocardial damage but did not evaluate the differences in effect according to MCFA type. Therefore, this study investigated the role of inflammatory cytokines in cancer-induced myocardial damage and the effects of three types of MCFAs (caprylic acid [C8], capric acid [C10], and lauric acid [C12]). In a mouse model, the C8 diet showed a greater effect on improving myocardial damage compared with C10 and C12 diets. Myocardial tubes differentiated from H9C2 cardiomyoblasts demonstrated increased mitochondrial oxidative stress, decreased membrane potential and mitochondrial volume, and inhibited myocardial tube differentiation following treatment with high-mobility group box-1 (HMGB1) but not interleukin-6 and tumor necrosis factor-α cytokines. However, HMGB1 treatment combined with C8 improved HMGB1-induced mitochondrial damage, enhanced autophagy, and increased mitochondrial biogenesis and maturation. However, these effects were only partial when combined with beta-hydroxybutyrate, a C8 metabolite. Thus, HMGB1 may play an important role in cancer-related myocardial damage. C8 counteracts HMGB1’s effects and improves cancer-related myocardial damage. Further clinical studies are required to investigate the effects of C8.
Turbofan Performance Estimation Using Neural Network Component Maps and Genetic Algorithm-Least Squares Solvers
Authors: Lombardo Giuseppe , Lo Greco Pierantonio , Benedetti Ivano
Published: July 2024

Computational models of turbofans that are oriented to assist the design and testing of innovative components are of fundamental importance in order to reduce their environmental impact. In this paper, we present an effective method for developing numerical turbofan models that allows reliable steady-state turbofan performance calculations. The main difference between the proposed method and those used in various commercial algorithms, such as GasTurb, GSP 12 and NPSS, is the use of neural networks as a multidimensional interpolation method for rotational component maps instead of classical β parameter. An additional aspect of fundamental importance lies in the simplicity of implementing this method in Matlab and the high degree of customization of the turbofan components without performing any manipulation of variables for the purpose of reducing the dimensionality of the problem, which would normally lead to a high condition number of the Jacobian matrix associated with the nonlinear turbofan system (and, thus, to significant error). In the proposed methodology, the component behavior can be modeled by analytical relationships and through the use of neural networks trained from component bench test data or data obtained from CFD simulations. Generalization of rotational component maps by feedforward neural networks leads to an average interpolation error up to around 1%, for all variables. The resulting nonlinear system is solved by a combined genetic algorithm and least squares algorithm approach, instead of the standard Newton’s method. The turbofan numerical model turns out to be convergent, and results suggest that the trend in overall turbofan performance, as flight conditions change, is in agreement with the outputs of the GSP 12 software.
Impaired Gastrointestinal Motility and Worsening Heart Failure in Patients Receiving Trans-Catheter Aortic Valve Replacement
Authors: Imamura Teruhiko , Narang Nikhil , Ushijima Ryuichi , Sobajima Mitsuo , Fukuda Nobuyuki , Ueno Hiroshi , Kinugawa Koichiro
Published: July 2024

Background: Impaired gastric motility in the form of constipation may often occur in elderly patients with chronic heart failure. Candidates for trans-catheter aortic replacement (TAVR) are of old age and have multiple comorbidities, probably including constipation. However, the clinical implication of a history of constipation in patients receiving TAVR remains unknown. Methods: Patients who underwent TAVR at our large academic center between 2015 and 2022 were eligible. The prognostic impact of the prescribed laxative type and number, which was assumed as the severity of constipation, on the incidence of death or heart failure readmission two years after index discharge was investigated. Results: A total of 344 patients were included. Median age was 85 years, and 99 patients were men. Patients with any laxatives (N = 166) had higher systolic blood pressure, higher plasma B-type natriuretic peptide levels, and a lower prescription rate of renin–angiotensin system inhibitors at the time of index discharge after TAVR (p < 0.05 for all). The number of laxative types was independently associated with the composite primary outcome with an adjusted hazard ratio of 1.83 (95% confidence interval 1.27–2.63, p = 0.001) with a cutoff of one type of laxative used, which significantly stratified the 2-year cumulative incidence of the primary outcome (18% versus 7%, p = 0.001). Conclusions: The presence of constipation was associated with worse clinical outcomes following TAVR. The prognostic impact of an aggressive intervention for constipation remains a future concern in this cohort.
Treatment of Intrabony Defects with Non-Surgical Subgingival Debridement: A Radiographic Evaluation of Bone Gain Using an Experimental Digital Software “Bone Defect Analysis (BDA)”
Authors: Pardo Alessia , Bonfante Laura , Signoriello Annarita , Benetti Andrea , Barillari Marco , Zanutto Piero , Lombardo Giorgio
Published: July 2024

Background: The aim of this study was to retrospectively evaluate the 3-year radiographic outcomes of periodontal intrabony defects treated with non-surgical subgingival therapy (NST), assessing radiographic bone gain (RBG) through experimental digital software, named “Bone Defect Analysis (BDA)”. Methods: The study included 17 intrabony defects in 14 patients. BDA software (version 1) was used on radiographs to calculate RBG (in %) and variations in defect angle (in °) between baseline (T0) and 3-year follow-up (T1). Soft tissue conditions were registered, reporting bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL). Defects were analyzed according to angles less (group A) or greater (group B) than 30°. Results: Nine and eight defects were, respectively, analyzed in groups A and B. Three years after treatment, an average RBG of 12.28% was found overall, with 13.25% and 10.11% for groups A and B, respectively (p = 0.28). Clinically, a mean CAL of 6.05 mm at T1 (from 10.94 mm at T0) was found, with 6.88 mm and 5.12 mm in groups A and B, respectively (p = 0.07). Conclusions: BDA software demonstrated predictability in the evaluation of bone variations after NST, revealing better clinical findings for intrabony defects with an initial smaller angle.
An Ultra-Low-Voltage Approach to Accurately Set the Quiescent Current of Digital Standard Cells Used for Analog Design and Its Application on an Inverter-Based Operational Transconductance Amplifier
Authors: Della Sala Riccardo , Centurelli Francesco , Scotti Giuseppe
Published: July 2024

An approach to design analog building blocks based on digital standard cells is presented in this work. By ensuring that every CMOS inverter from a standard-cell library operates with a well-defined quiescent current and output voltage, the suggested method makes it possible to construct analog circuits that are resistant against PVT variations. The method uses the local supply voltages connected to the source terminals of the p-channel and n-channel MOS transistors of the standard-cell inverters as control inputs. It is based on adaptive supply voltage generator (ASVG) reusable blocks, which are comparable to those used in digital applications to handle process variations. All of the standard-cell inverters used for analog functions receive the local supply voltages produced by the ASVGs, which enable setting each cell’s quiescent current to a multiple of a reference current and each cell’s static output voltage to an appropriate reference voltage. Both the complete custom design of the ASVG blocks and a theoretical study of the feedback loop of the ASVG are presented. An application example through the design of a fully synthesizable two-stage operational transconductance amplifier (OTA) is also provided. The TSMC 180 nm CMOS technology has been used to implement both the OTA and the ASV generators. Simulation results have demonstrated that the proposed approach allows to accurately set the quiescent current of standard-cell inverters, dramatically reducing the effect of PVT variations on the pmain performance parameters of the standard-cell-based two-stage OTA.
Modelled Water and Phosphorus Transports in the Archipelago Sea and through the Åland Sea in the Northern Baltic Sea and Their Links to Water Quality
Authors: Helminen Harri , Inkala Arto
Published: July 2024

The Baltic Sea is currently classified as ‘affected by eutrophication’. In this study, water exchanges and net phosphorus flows in the Archipelago Sea and through the Åland Sea from the Baltic proper was estimated with the aid of a 3-D hydrodynamic model for the years 2000–2021. The modelling configuration is based on the Copernicus regional reanalysis data. Water flowed from the Baltic proper to the Bothnian Sea at 669 km3/a and out from there at 879 km3/a. The inflow occurred in the deep-water layer (over 40 m), while the outflow occurred in the surface layer (0–40 m). With the inflow, 14,500 tons/a of phosphorus were transported during the years 2000–2014, but the amount increased to 20,300 tons per year from 2015 to 2021. At the same time, the winter-time concentrations of DIP in the Bothnian Sea almost doubled. In the Archipelago Sea, the main flow direction of water was from south to north from 2000 to 2014. From 2015 to 2021, the net flow direction reversed, and water flowed from the Archipelago Sea to the Baltic proper in the surface layer at a rate of 140 km3/a. At the same time, the background loading of phosphorus entering the Archipelago Sea with the flows decreased significantly and the chlorophyll-a concentration decreased below the threshold for a good ecological status. The U-turn in surface currents in the Archipelago Sea since 2015 may be related to variations in upwellings caused by climate change.
A Novel Bézier LSTM Model: A Case Study in Corn Analysis
Authors: Zhao Qingliang , Chen Junji , Feng Xiaobin , Wang Yiduo
Published: July 2024

Accurate prediction of agricultural product prices is instrumental in providing rational guidance for agricultural production planning and the development of the agricultural industry. By constructing an end-to-end agricultural product price prediction model, incorporating a segmented Bézier curve fitting algorithm and Long Short-Term Memory (LSTM) network, this study selects corn futures prices listed on the Dalian Commodity Exchange as the research subject to predict and validate their price trends. Firstly, corn futures prices are fitted using segmented Bézier curves. Subsequently, the fitted price sequence is employed as a feature and input into an LSTM network for training to obtain a price prediction model. Finally, the prediction results of the Bézier curve-based LSTM model are compared and analyzed with traditional LSTM, ARIMA (Autoregressive Integrated Moving Average Model), VMD-LSTM, and SVR (Support Vector Regression) models. The research findings indicate that the proposed Bézier curve-based LSTM model demonstrates significant predictive advantages in corn futures price prediction. Through comparison with traditional models, the effectiveness of this model is affirmed. Consequently, the Bézier curve-based LSTM model proposed in this paper can serve as a crucial reference for agricultural product price prediction, providing effective guidance for agricultural production planning and industry development.
Macrolactin XY, a Macrolactin Antibiotic from Marine-Derived Bacillus subtilis sp. 18
Authors: Xu Yao , Song Yihao , Ning Yaodong , Li Song , Qu Yingxin , Jiao Binghua , Lu Xiaoling
Published: July 2024

Two new compounds, macrolactin XY (1) and (5R, 9S, 10S)-5-(hydroxymethyl)-1,3,7-decatriene-9,10-diol (2), together with nine known compounds (3–11) were isolated from the marine Bacillus subtilis sp. 18 by the OSMAC strategy. These compounds were evaluated for antibacterial activity against six tested microorganisms. Compounds 1–5 and 7–10 showed varied antibacterial activity, with the minimum inhibitory concentration (MIC) ranging from 3 to 12 μg/mL. Macrolactin XY (1) was found to possess superior antibacterial activity, especially exhibiting significant effectiveness against Enterococcus faecalis. The antibacterial activity mechanism against E. faecalis was investigated. The mechanism may disrupt bacterial cell membrane integrity and permeability, and also inhibit the expression of genes associated with bacterial energy metabolism, as established by the experiments concerning cell membrane potential, SDS-PAGE electrophoresis, cell membrane integrity, and key gene expressions. This study offers valuable insights and serves as a theoretical foundation for the future development of macrolactins as antibacterial precursors.
Does the Presence of Matted Nodes in Colon Adenocarcinoma Influence 5-Year Overall Survival?
Authors: Rodríguez-López Karla I. , Salazar-Castillo Mariana , Lino-Silva Leonardo S. , Galán-Ramírez Ángeles , Rivera-Moncada Luisa F. , López-Jiménez Emiliano A. , Zepeda-Najar César
Published: July 2024

Background and Objectives: Colon cancer (CC) is prevalent globally, constituting 11.9% of cases in Mexico. Lymph node metastases are established prognostic indicators, with extracapsular lymph node extension (ENE) playing a crucial role in modifying prognosis. While ENE is associated with adverse factors, certain aspects, like matted nodes (lymph node conglomerates), are underexplored. Matted nodes, clusters of lymph nodes infiltrated by cancer cells, are recognized as an independent prognostic factor in other cancers. This study investigates the prognostic implications of matted nodes in CC. Materials and Methods: From a retrospective analysis of 502 CC consecutive cases treated with colectomy (2005–2018), we identified 255 (50.8%) cases with lymph node metastasis (our study group), which were categorized into two groups: (1) lymph node metastasis alone (n = 208), and (2) lymph node metastasis with matted nodes (n = 47). A comparative survival analysis was performed. Results: Of the 255 patients, 38% had lymph node metastasis. Patients with matted nodes (18.4%) showed an association with higher pN stage and lymphovascular invasion. The 5-year survival rate for patients with matted nodes was 47.7%, compared to 60% without (p = 0.096); however, this association demonstrated only a statistical tendency. Multivariate analysis identified clinical stage and adjuvant chemotherapy use as independent factors contributing to survival. Conclusions: This study underscores matted nodes as potential prognostic indicators in CC, emphasizing their association with higher pN stage and reduced survival. Although the patients with matted nodes showed lower survival, this figure did not search statistical significance, but a tendency was detected, which necessitates precise further research, which is essential for validating these findings and integrating matted nodes into the broader context of colorectal cancer management.
The Influence of Hip-Strengthening Program on Patients with Chronic Ankle Instability
Authors: Yeum Woo-Jin , Lee Mi-Young , Lee Byoung-Hee
Published: July 2024

Background and Objectives: Repetitive ankle sprains lead to mechanical instability of the ankle. Patients with chronic ankle instability may experience decreased muscle strength and limited postural control. This study investigated the effects of a hip-strengthening exercise program on muscle strength, balance, and function in patients with chronic ankle instability. Materials and Methods: A total of 30 patients participated in the study and were randomly assigned to the two groups. Among the 30 participants, 14 were assigned to the hip joint-strengthening exercise group and 16 to the control group. The experimental group underwent a hip-strengthening exercise program and received training for 40 min per session twice a week for four weeks. The control group received the same frequency, duration, and number of sessions. Measurements were performed before and after the training period to assess changes in hip strength, balance, and function. Results: In the within-group and between-group comparisons, both groups showed significant differences in hip joint strength, static balance, dynamic balance, and function (FAAM; foot and ankle ability measures) (p < 0.05). Statistically significant differences were observed in the time × group interaction effects among the hip abductors and external rotation in hip joint strength, path length in static balance, posterolateral and posteromedial in dynamic balance, and FAAM-ADL and FAAM-SPORT functions (p < 0.05). Conclusions: Accordingly, this study confirmed that hip joint-strengthening exercises have a positive effect on the strength, balance, and function of patients with chronic ankle instability, and we believe that hip joint-strengthening exercises will be recommended as an effective intervention method for patients suffering from chronic ankle instability.
Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism
Authors: Shen Xinyu , Mu Xiaoqin
Published: July 2024

Stroke, as a serious cerebral vascular disease with high incidence and high rates of disability and mortality, has limited therapeutic options due to the narrow time window. Compelling evidence has highlighted the significance of the gut microbiota and gut–brain axis as critical regulatory factors affecting stroke. Along the microbiota–gut–brain axis, tryptophan metabolism further acquires increasing attention for its intimate association with central nervous system diseases. For the purpose of exploring the potential role of tryptophan metabolism in stroke and providing systematic insights into the intricate connection of the microbiota–gut–brain axis with the pathological procedure of stroke, this review first summarized the practical relationship between microbiota and stroke by compiling the latest case-control research. Then, the microbiota–gut–brain axis, as well as its interaction with stroke, were comprehensively elucidated on the basis of the basic anatomical structure and physiological function. Based on the crosstalk of microbiota–gut–brain, we further focused on the tryptophan metabolism from the three major metabolic pathways, namely, the kynurenine pathway, serotonin pathway, and microbial pathway, within the axis. Moreover, the effects of tryptophan metabolism on stroke were appreciated and elaborated here, which is scarcely found in other reviews. Hopefully, the systematic illustration of the mechanisms and pathways along the microbiota–gut–brain axis will inspire more translational research from metabolic perspectives, along with more attention paid to tryptophan metabolism as a promising pharmaceutical target in order to reduce the risk of stroke, mitigate the stroke progression, and ameliorate the stroke prognosis.
Photosynthetic Activities, Phytohormones, and Secondary Metabolites Induction in Plants by Prevailing Compost Residue
Authors: Abbey Lord , Asiedu Samuel Kwaku , Chada Sparsha , Ofoe Raphael , Amoako Peter Ofori , Owusu-Nketia Stella , Ajeethan Nivethika , Kumar Anagha Pradeep , Nutsukpo Efoo Bawa
Published: July 2024

Compost residue enriches soil health with the potential to enhance plant metabolism and hormonal balance, but has not yet been studied. A study was performed to determine how prevailing compost residue induces tomato (Solanum lycopersicum ‘Scotia’) plant morpho-physiology, phytohormones, and secondary metabolites. Plants were grown in soils with a previous history of annual (AN) and biennial (BI) compost amendments. The controls were soil without compost (C) amendment and municipal solid waste compost (MSWC) alone. The MSWC- and AN-plants had similar and significantly (p < 0.05) highest growth and photosynthetic activities compared to the BI- or C-plants. Total phenolics and lipid peroxidase activity were significantly (p < 0.001) high in BI-plants, while hydrogen peroxide and antioxidant capacity were significantly (p < 0.001) high in AN-plants. MSWC-plants recorded the highest cis-abscisic acid, followed by AN-, and then BI- and C-plants. Cis-zeatin, trans-zeatin, and isopentenyladenine ribosides were detected in the MSWC- and AN-plants but not in the BI- or C-plants. Furthermore, gibberellins GA53, GA19, and GA8 were high in the MSWC-plants, but only GA8 was detected in the AN plants and none in the others. Besides, MSWC plants exhibited the highest content of 1-aminocyclopropane-1-carboxylic acid. Conjugated salicylic acid was highest in the BI-plants, while jasmonic acid-isoleucine was highest in MSWC-plants and C plants. In conclusion, prevailing compost chemical residues upregulate plant growth, phytohormones, and metabolic compounds that can potentially increase plant growth and abiotic stress defense. Future work should investigate the flow of these compounds in plants under abiotic stress.
Influence of Pd-Layer Thickness on Bonding Reliability of Pd-Coated Cu Wire
Authors: Fan Junling , Yuan Donglin , Du Juan , Hou Tao , Wang Furong , Cao Jun , Yang Xuemei , Zhang Yuemin
Published: July 2024

In this paper, three Pd-coated Cu (PCC) wires with different Pd-layer thicknesses were used to make bonding samples, and the influence of Pd-layer thickness on the reliability of bonded points before and after a high-temperature storage test was studied. The results show that smaller bonding pressure and ultrasonic power lead to insufficient plastic deformation of the ball-bonded point, which also leads to small contact area with the pad and low bonding strength. Excessive bonding pressure and ultrasonic power will lead to ‘scratch’ on the surface of the pad and large-scale Ag spatter. The wedge-bonded point has a narrowed width when the bonding pressure and ultrasonic power are too small, and the tail edge will be cocked, resulting in false bonding and low strength. When the bonding pressure or ultrasonic power is too large, it will cause stress concentration, and the pad will appear as an ‘internal injury’, which will improve the failure probability; a high-temperature environment can make Cu-Ag intermetallic compounds (IMCs) grow and improve the bonding strength. With the extension of high-temperature storage time, the shear force of Pd100 gradually reaches the peak and then decreases, due to Kirkendall pores caused by excessive growth of IMCs, while the shear force of Pd120 continued to increase due to the slow growth rate of IMCs. In the high-temperature storage test, the thicker the Pd layer of the bonding wire, the higher the bonding strength; in the cold/hot cycle test, the sample with the largest Pd-layer thickness has the lowest failure rate. The thicker the Pd layer, the stronger its ability to resist changes in the external environment, and the higher its stability and reliability.
Room-Temperature (RT) Extended Short-Wave Infrared (e-SWIR) Avalanche Photodiode (APD) with a 2.6 µm Cutoff Wavelength
Authors: Benker Michael , Gu Guiru , Senckowski Alexander , Xiang Boyang , Dwyer Charles , Adams Robert , Xie Yuanchang , Nagarajan Ramaswamy , Li Yifei , Lu Xuejun
Published: July 2024

Highly sensitive infrared photodetectors are needed in numerous sensing and imaging applications. In this paper, we report on extended short-wave infrared (e-SWIR) avalanche photodiodes (APDs) capable of operating at room temperature (RT). To extend the detection wavelength, the e-SWIR APD utilizes a higher indium (In) composition, specifically In0.3Ga0.7As0.25Sb0.75/GaSb heterostructures. The detection cut-off wavelength is successfully extended to 2.6 µm at RT, as verified by the Fourier Transform Infrared Spectrometer (FTIR) detection spectrum measurement at RT. The In0.3Ga0.7As0.25Sb0.75/GaSb heterostructures are lattice-matched to GaSb substrates, ensuring high material quality. The noise current at RT is analyzed and found to be the shot noise-limited at RT. The e-SWIR APD achieves a high multiplication gain of M~190 at a low bias of Vbias=− 2.5 V under illumination of a distributed feedback laser (DFB) with an emission wavelength of 2.3 µm. A high photoresponsivity of R>140 A/W is also achieved at the low bias of Vbias=−2.5 V. This type of highly sensitive e-SWIR APD, with a high internal gain capable of RT operation, provides enabling technology for e-SWIR sensing and imaging while significantly reducing size, weight, and power consumption (SWaP).
Five-Surface Phosphor-in-Glass for Enhanced Illumination and Superior Color Uniformity in Large-View Scale LEDs
Authors: Huang Hong-Wei , Huang Chien-Wei , Chen Yi-Chian , Shih Hsing-Kun , Cheng Wei-Chih , Liu Chun-Nien , Chiang Chia-Chin
Published: July 2024

A novel five-surface phosphor-in-glass (FS-PiG) structure for high illumination and excellent color uniformity in large-view scale LEDs for sensor light source application is demonstrated. YAG phosphor (Y3Al5O12:Ce3+) was uniformly mixed with ceramic and sintered at 680 °C to form a phosphor wafer. Sophisticated laser engraving was employed on the phosphor wafer to form saddle-shaped large-view scale FS-PiG LEDs. The performance of the FS-PiG LEDs exhibited an illumination of 401 lm, average color temperature (CCT) of 5488 K ± 110 K, and color coordinates (CIE) of (0.3179 ± 0.003, 0.3352 ± 0.003). In contrast to convention single-surface phosphor-in-glass (SS-PiG) LEDs, the performance exhibited an illumination of 380 lm, average CCT of 5830 K ± 758 K, and CIE of (0.3083 ± 0.07, 0.3172 ± 0.07). These indicated that the performance of the FS-PiG LEDs was higher than the SS-PiG LEDs for illumination, CCT, and CIE by 1.7, 7, and 23 times, respectively. Furthermore, the FS-PiG LEDs demonstrate a lower lumen loss of 2% and a reduced chromaticity shift of 5.4 × 10−3 under accelerated aging at 350 °C for 1008 h, owing to the high ceramic melting temperature of up to 510 °C. In this study, the proposed FS-PiG large-view scale LEDs with excellent optical performance and high reliability may be promising candidates to replace the conventional phosphor-in-organic silicone material used in high-power LEDs for the next generation of sensor light sources, display, and headlight applications.
Accuracy and Precision of the Geopyörä Breakage Test
Authors: Bueno Marcos , Almeida Thiago , Lara Leonardo , Powell Malcolm , Delboni Homero
Published: July 2024

The Geopyörä breakage test uses two counter-rotating wheels to nip and crush rock specimens with a tightly controlled gap between rollers. This paper presents the detailed measures conducted to evaluate the accuracy and precision of energy measurements across various ore types using the Geopyörä. Force measurement was assessed just for its precision. The outputs were compared directly to the drop weight test (DWT) measures of fragmentation at the same energy and fitted A and b parameters. Test reproducibility was evaluated using a Round-Robin methodology, testing several samples in multiple laboratories. The results confirmed that the new test has sufficient accuracy to match DWT results and excellent precision to assure reproducibility.
Palaeoclimatic Inferences from Clayey-Iron Palaeosols: A Weathering Event Recorded in the Middle–Upper Jurassic Unconformity (South Iberian Palaeomargin, Western Tethys)
Authors: Laita Elisa , Abad Isabel , Reolid Matías
Published: July 2024

The study of iron crusts containing iron-coated grains from different sections of the Prebetic (SE Iberia) and the overlying marine sedimentary rocks also containing iron-coated grains in the Prebetic and the Iberian Range (NE Iberia) allowed us to determine the palaeoclimatic and palaeoenvironmental conditions under which they originated. The iron crusts are mainly composed of clay minerals (kaolinite and illitic phases) and/or goethite and hematite. The kaolinite texture indicates that it is authigenic, whereas the illitic phases are probably detrital. The mineralogy and texture of the iron crusts allow us to classify them as plinthitic palaeosols. The iron-coated grains consisting of a nucleus and a cortex, both composed of a mixture of kaolinite, goethite, and hematite, originated in situ during the plinthite development. Reworking processes caused the fragmentation and incorporation of the iron-coated grains into the overlying ferruginous oolithic limestones and terrigenous-carbonated breccia. New marine iron-coated grains formed later in the ferruginous oolithic limestones. The high Chemical Index of Alteration and Chemical Index of Weathering values and the geochemical ratios (Ba/Sr, Rb/Sr, Sr/Cu, Ga/Rb) from iron deposits reflect intense weathering under warm and humid conditions in the South Iberian Palaeomargin during the Callovian–Oxfordian, which may also take place in the East Iberian Palaeomargin (Iberian Range).
What Are the Key Factors for the Detection of Peptides Using Mass Spectrometry on Boron-Doped Diamond Surfaces?
Authors: Aguedo Juvissan , Vojs Marian , Vrška Martin , Nemcovic Marek , Pakanova Zuzana , Dragounova Katerina Aubrechtova , Romanyuk Oleksandr , Kromka Alexander , Varga Marian , Hatala Michal , Marton Marian , Tkac Jan
Published: July 2024

We investigated the use of boron-doped diamond (BDD) with different surface morphologies for the enhanced detection of nine different peptides by matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS). For the first time, we compared three different nanostructured BDD film morphologies (Continuous, Nanograss, and Nanotips) with differently terminated surfaces (-H, -O, and -F) to commercially available Ground Steel plates. All these surfaces were evaluated for their effectiveness in detecting the nine different peptides by MALDI-MS. Our results demonstrated that certain nanostructured BDD surfaces exhibited superior performance for the detection of especially hydrophobic peptides (e.g., bradykinin 1–7, substance P, and the renin substrate), with a limit of detection of down to 2.3 pM. Further investigation showed that hydrophobic peptides (e.g., bradykinin 1–7, substance P, and the renin substrate) were effectively detected on hydrogen-terminated BDD surfaces. On the other hand, the highly acidic negatively charged peptide adrenocorticotropic hormone fragment 18–39 was effectively identified on oxygen-/fluorine-terminated BDD surfaces. Furthermore, BDD surfaces reduced sodium adduct contamination significantly.
Body Composition and Dietary Intake Profiles of Elite Iranian Swimmers and Water Polo Athletes
Authors: Samanipour Mohammad Hossein , Mohammadian Shahzad , Del Coso Juan , Salehian Omid , Jeddi Fatemeh Khodakhah , Khosravi Mehdi , González-Ravé José M. , Ceylan Halil İbrahim , Liu Hongyou , Abou Sawan Sidney , Jäger Ralf
Published: July 2024

Background: This study aimed to conduct a detailed and comparative analysis of body composition and dietary habits in elite swimming and water polo athletes. Through the examination of these key parameters, this study seeks to compare the dietary intake of these two distinct aquatic sports disciplines. Methods: A total of 10 top-level swimmers and 13 water polo athletes participated in anthropometric and body composition assessments, as well as a detailed analysis of nutritional intake. To compare the two groups, an independent samples t-test was used, and variance homogeneity was checked using Levene’s test. The effect size of the group differences was evaluated using Hedges’ g. Results: Water polo athletes showed significantly greater height (189.4 ± 2.9 vs. 186.5 ± 2.0 cm, p = 0.013), body mass index (24.3 ± 1.4 vs. 22.1 ± 0.5 kg/m2, p < 0.001), fat-free mass (62.9 ± 1.4 vs. 61.1 ± 1.38 kg, p < 0.001), skeletal muscle mass (47.1 ± 1.3 vs. 43.9 ± 1.6 kg, p < 0.001), and overall weight (86.9 ± 6.9 vs. 76.7 ± 2.2 kg, p < 0.001) in comparison to swimmers. Swimmers consumed greater amounts of mean daily energy (60.0 ± 1.0 vs. 39.0 ± 1.0 kcal/kg, p < 0.001), carbohydrate (7.8 ± 0.3 vs. 4.4 ± 0.5 g/kg, p < 0.001), protein (1.7 ± 0.5 vs. 1.4 ± 0.5 g/kg, p < 0.001), and fat (2.4 ± 0.5 vs. 1.7 ± 0.5 g/kg, p < 0.001) compared to water polo athletes. Conclusion: Our findings highlight the need for differentiated targeted nutritional interventions to enhance athletic performance in different types of water sports. Compared to water polo athletes, swimmers consumed significantly higher amounts of calories, matching their increased calorie demand from their specific training regime. However, this is an observational study and the differential needs of energy and macronutrients in water sports should be confirmed by studies with energy expenditure measurements.
Brain Perception of Different Oils on Appetite Regulation: An Anorectic Gene Expression Pattern in the Hypothalamus Dependent on the Vagus Nerve
Authors: Lopes Gele de Carvalho Araújo , Miranda Brenda Caroline Rodrigues , Lima João Orlando Piauilino Ferreira , Martins Jorddam Almondes , de Sousa Athanara Alves , Nobre Taline Alves , Severo Juliana Soares , da Silva Tiago Eugênio Oliveira , Afonso Milessa da Silva , Lima Joana Darc Carola Correia , de Matos Neto Emidio Marques , Torres Lucillia Rabelo de Oliveira , Cintra Dennys Esper , Lottenberg Ana Maria , Seelaender Marília , Silva Moisés Tolentino Bento da , Torres-Leal Francisco Leonardo
Published: July 2024

(1) Background: We examined the effect of the acute administration of olive oil (EVOO), linseed oil (GLO), soybean oil (SO), and palm oil (PO) on gastric motility and appetite in rats. (2) Methods: We assessed food intake, gastric retention (GR), and gene expression in all groups. (3) Results: Both EVOO and GLO were found to enhance the rate of stomach retention, leading to a decrease in hunger. On the other hand, the reduction in food intake caused by SO was accompanied by delayed effects on stomach retention. PO caused an alteration in the mRNA expression of NPY, POMC, and CART. Although PO increased stomach retention after 180 min, it did not affect food intake. It was subsequently verified that the absence of an autonomic reaction did not nullify the influence of EVOO in reducing food consumption. Moreover, in the absence of parasympathetic responses, animals that received PO exhibited a significant decrease in food consumption, probably mediated by lower NPY expression. (4) Conclusions: This study discovered that different oils induce various effects on parameters related to food consumption. Specifically, EVOO reduces food consumption primarily through its impact on the gastrointestinal tract, making it a recommended adjunct for weight loss. Conversely, the intake of PO limits food consumption in the absence of an autonomic reaction, but it is not advised due to its contribution to the development of cardiometabolic disorders.
Mediation Effect of Obesity on the Association of Socioeconomic Status with Blood Pressure in the Elderly Hypertensive Population
Authors: Wang Saiyi , Miao Yudong , Feng Yifei , Zhao Lipei , Wu Xiaoman , Jia Shiyu , Zhao Weijia , Tarimo Clifford Silver , Zuo Yibo , Guo Xinghong , Ma Mingze , Wu Jian
Published: July 2024

Background: Socioeconomic status (SES) plays a crucial role in blood pressure (BP) control. SES may influence BP control through obesity indices, such as body mass index (BMI) and waist circumference (WC). This study aimed to understand the relationships between SES and BP control in the elderly hypertensive population, and to determine whether BMI and WC mediate the relationship between SES and BP control. Methods: The study was conducted in Jia County, Henan Province, China, from 1 July to 31 August 2023. The 18,963 hypertensive people over 65 years old who were included in the National Basic Public Health Service Program were investigated. The study utilized questionnaire surveys to collect data on participants’ demographic characteristics, disease history, lifestyle behaviors, antihypertensive medication, and measured height, weight, and blood pressure. SES was indexed by participants’ self-reported educational level, family income, and occupation, and categorized into low, medium, and high groups by using latent category analysis (LCA). Logistic regression models were used to analyze the associations between SES and BP control. Obesity indicators, represented by BMI and WC, were included in mediation models to examine the indirect effects of BMI/WC on the association between SES and BP control. Results: The mean age of 17,234 participants was 73.4 years and 9888 (57.4%) of the participants were female. The LCA results indicated the number of participants in low SES, middle SES, and high SES groups were 7760, 8347, and 1127, respectively. Compared with the low SES group, the odds ratios (ORs) and 95% confidence intervals (CIs) for the association of BP control with middle SES and high SES were 1.101 (1.031, 1.175), and 1.492 (1.312, 1.696). This association was similarly found in the subsequent subgroup analyses (p < 0.05). Compared with low SES, our findings further suggested that BMI (indirect effects: 95% CIs: −0.004–−0.001; p < 0.001) and WC (indirect effects: 95% CIs: −0.003–−0.001; p = 0.020) play a suppressing role in the association between high SES and BP control. Conclusions: Our study indicated that the elderly hypertensive population with high SES may have a better result for BP control. However, we found that BMI/WC plays a suppressing role in this association. This indicated that despite the better BP control observed in elderly hypertensive populations with high SES, BMI and WC might undermine this beneficial relationship. Therefore, implementing strategies for obesity prevention is an efficient way to maintain this beneficial association between high SES and BP control.
A Qualitative Study Supporting Optimal Nutrition in Advanced Liver Disease—Unlocking the Potential for Improvement
Authors: Ludlow Shaye , Farragher Katherine , Squires Kelly , Heaney Susan , Orman Jessica , Pullen Sarah , Attia John , Wynne Katie
Published: July 2024

Malnutrition rates in Advanced Liver Disease (ALD) are significantly higher than those in well-compensated liver disease. In addition to its physiological impact, malnutrition is detrimental for quality of life and social, emotional, and psychological well-being. Studies within oncology and renal supportive care have identified the influence of non-physiological factors on malnutrition risk. Integrating similar factors into malnutrition screening for ALD could improve identification of at-risk patients to optimize treatment planning. This qualitative study aimed to understand the holistic factors influencing nutritional status in the ALD population. Semi-structured interviews with 21 patients, carers, and clinicians explored the experiences of malnutrition in ALD. Thematic analysis revealed five key themes: (i) appropriateness of healthcare delivery; (ii) health- and food-related factors; (iii) high symptom burden, (iv) social support impacting well-being, and (v) physical and structural supports. Current screening methods do not adequately capture all potential drivers of malnutrition in the ALD population. Adopting a more supportive approach including both physiological and non-physiological factors in ALD malnutrition screening may promote more timely and comprehensive nutritional interventions that address the complex and holistic needs of patients living with ALD.
Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression
Authors: Costa João Panão , de Carvalho Armando , Paiva Artur , Borges Olga
Published: July 2024

Hepatitis B, caused by the hepatitis B virus (HBV), often progresses to chronic infection, leading to severe complications, such as cirrhosis, liver failure, and hepatocellular carcinoma. Chronic HBV infection is characterized by a complex interplay between the virus and the host immune system, resulting in immune cell exhaustion, a phenomenon commonly observed in chronic viral infections and cancer. This state of exhaustion involves elevated levels of inhibitory molecules, cells, and cell surface receptors, as opposed to stimulatory counterparts. This review aims to elucidate the expression patterns of various co-inhibitory and co-stimulatory receptors on immune cells isolated from chronic hepatitis B (CHB) patients. By analyzing existing data, the review conducts comparisons between CHB patients and healthy adults, explores the differences between HBV-specific and total T cells in CHB patients, and examines variations between intrahepatic and peripheral immune cells in CHB patients. Understanding the mechanisms underlying immune exhaustion in CHB is crucial for developing novel immunotherapeutic approaches. This detailed analysis sheds light on the immune exhaustion observed in CHB and lays the groundwork for future combined immunotherapy strategies aimed at leveraging checkpoint receptors to restore immune function and improve clinical outcomes.