bluuebunny/crossref_metadata_2025 huggingface dataset:
SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells
Authors: Han Xiuxin , Liu Fengting , Zhang Chao , Ren Zhiwu , Li Lili , Wang Guowen
Published: September 2018

Osteosarcoma (OS) patients often exhibit pulmonary metastasis, which results in high patient mortality. Our present study established the doxorubicin (Dox) resistant human OS MG-63 and HOS cells and named them MG-63/Dox and HOS/Dox, respectively. The Dox resistant OS cells had greater invasion ability than that of parental cells. The expression of ZEB1, while not FOXM1, Snail, HIF-1α, or Sp1, was significantly increased in Dox resistant OS cells. Silencing of ZEB1 can attenuate the metastasis and increase Dox sensitivity of MG-63/Dox and HOS/Dox cells. The upregulation of ZEB1 can increase of the expression of interlukin-6 (IL-6). Anti-IL-6 inhibited the invasion and increase the Dox sensitivity of MG-63/Dox and HOS/Dox cells. There was no significant difference of ZEB1 mRNA between Dox resistant and control cells. The upregulation of ZEB1 in Dox resistant OS cells can be attributed to the increase of protein half-life. This was confirmed by results that the inhibitor of proteasomal degradation can increase ZEB1 in Dox resistant OS cells. Over expression of SIAH1 can inhibit the expression of ZEB1 and increase the Dox sensitivity of MG-63/Dox and HOS/Dox cells. Collectively, we confirmed that SIAH1 induced ZEB1 is involved in the Dox resistance of OS cells.
Production of Iron Based Alloys from Mill Scale through Metallothermic Reduction
Authors: Bugdayci Mehmet , Alkan Murat , Turan Ahmet , Yücel Onuralp
Published: September 2018

Mill scale (MS) has a potential to use as an iron source because of its high iron content. MS mainly consists of a mixture of iron oxides, metallic iron and other base metal oxides. MS is formed on the surfaces of steel ingots during continuous casting as a waste material. In this study, the use of MS as an iron source for the production of carbon-free iron containing alloys (unalloyed iron, Fe-Ni, Fe-Cr-Ni, Fe-Cr-Ni-Mo) via a metallothermic reduction process was investigated. Thermodynamic calculations and the experimental studies were performed on the basis of 100 g of MS. The effects of different stoichiometric amounts of MS and aluminum (Al) powders (as reductant) were investigated for the production of unalloyed Fe. While, different amount of metal oxide ratios and their effects on metal recoveries, compositions and microstructure of final alloys were studied during Fe-based alloys production. The highest iron recovery during unalloyed Fe production was obtained as 95.14 % by using 100 g of MS and 100 % stoichiometric Al (28.6 g) containing mixture. In Fe-based alloys production series, the highest metal recovery values were reached up to 95.0 % for Fe, 95.1 % for Ni, 68.3 % for Cr and 77.2 % for Mo, respectively.
Kinetic and Thermodynamic Analysis of Thermal Decomposition of Deodar (Cedrus Deodara) Saw Dust and Rice Husk as Potential Feedstock for Pyrolysis
Authors: Rasool Tanveer , Srivastava Vimal Chandra , Khan M. N. S.
Published: September 2018

A comparative study on thermal analysis of two waste biomass materials of Kashmir namely deodar (Cedrus deodara) saw dust (DSD) and rice husk (RH), was carried out at different heating rates of 10, 25, 50 and 100 °C min−1 in air and nitrogen atmospheres. The onset, peak and burnout temperatures and rates of decomposition of components were determined and compared to understand the combustion and pyrolysis kinetics of selected biomass materials using iso-conversional Kissinger-Akahira-Sunose (KAS) and Ozawa-Flynn-Wall (OFW) models. The kinetic parameters calculated were in turn used to calculate the changes in thermodynamic parameters, the enthalpy (ΔH), the Gibbs free energy (ΔG) and the entropy (ΔS). The physicochemical characterisation was carried out by elemental analyser and FTIR spectroscopy. The average activation energy values for RH were found to be 107.6 and 101.2 kJ mol−1 in air atmosphere and 85.5 and 92.1 kJ mol−1 in nitrogen atmosphere based on KAS and OFW models, respectively. The activation energy for DSD on the other hand was found to be 89.9 and 95.3 kJ mol−1 in air, 179.2 and 180.6 kJ mol−1 under nitrogen atmosphere based on KAS and OFW models, respectively. The heating values of the two biomasses (~ 10 to16 MJ kg−1) and Gibbs free energy values (between 165 to 176 kJ mol−1) indicate that the selected biomass can not only prove to be potential feedstock for pyrolysis but also can become a useful source of energy and chemicals.
Green urine – understanding its importance
Authors: Barros Pinto Marco P.
Published: September 2018

The presence of a green urine is an unusual finding in the clinical laboratory. This could happen due to several underlying causes such as dyes, medicines, metabolic disorders or infections. In this case, the green color (a harmless side effect) was due to methylene blue used to evaluate the integrity of an anastomosis.
Investigation on the Aerodynamic Performance of the Compressor Cascade Using Blended Blade and End Wall
Authors: Yi Weilin , Li Jiabin , Ji Lucheng
Published: September 2018

Corner separation limits the increase of the aerodynamic loading in the compressor. Previous numerical studies indicate that the Blended Blade and End Wall (BBEW) technology is useful in delaying, or reducing, or even eliminating the corner separation. This paper presents combined experimental and numerical investigations on a BBEW cascade and its prototype. The experimental results show that the design of Blended Blade and End Wall (BBEW) can improve the performance of the cascade when the incidence angle was positive or at the design point, and the total pressure loss coefficient was reduced by 7 %-8 %. The performance improvement mainly located from 10 %-25 % span heights. Compared with the experiment data, the SST turbulence model shows the best results of the flow field. Based on the numerical results, the details of the flow field and the effect of the Blended Blade and End Wall (BBEW) design on the corner separation are discussed and analyzed.
Rare earth-copper-magnesium intermetallics: crystal structure of CeCuMg, magnetocaloric effect of GdCuMg and physical properties of the Laves phasesRECu4Mg (RE=Sm, Gd, Tb, Tm)
Authors: Stein Sebastian , Heletta Lukas , Block Theresa , Pöttgen Rainer
Published: September 2018

The intermetallic magnesium compounds CeCuMg and GdCuMg as well as the ternary Laves phasesRECu4Mg (RE=Sm, Gd–Tm) were synthesized from the elements by different annealing sequences in high-frequency and muffle furnaces using niobium ampoules as crucibles. All samples were characterized through the lattice parameters using X-ray powder diffraction (Guinier technique). Two structures were refined from single-crystal X-ray diffractometer data:a=764.75(6),c=414.25(4) pm, space groupP6̅2m,wR2=0.0389, 338F2values, 15 parameters for CeCuMg (ZrNiAl type) anda=723.18(2) pm, space groupF4̅3m, wR2=0.0818, 91F2values, eight parameters for Gd1.06(3)Cu4Mg0.94(3)(MgCu4Sn type). The Laves phase shows a small homogeneity range (Gd/Mg mixing). An investigation of the magnetocaloric effect (MCE) of ferromagnetic GdCuMg (ZrNiAl type;TC=82 K) revealed a magnetic entropy change of ΔSM=6.5 J kg−1K−1and a relative cooling power of RCP=260 J kg−1for a field change from 0 to 70 kOe, classifying GdCuMg as a moderate magnetocaloric material for theT=80 K region. Of the Laves phasesRECu4Mg, SmCu4Mg shows van-Vleck paramagnetism above a Néel temperature of 10.8(5) K, whereas GdCu4Mg and TbCu4Mg undergo antiferromagnetic phase transitions at about 48 and 30 K, respectively. TmCu4Mg shows Curie-Weiss behavior in the entire temperature range. The electrical resistivity of SmCu4Mg and the specific heat capacity of GdCu4Mg were measured for further characterization.
Effects of an 8-Week In-Season Elastic Band Training Program on Explosive Muscle Performance, Change of Direction, and Repeated Changes of Direction in the Lower Limbs of Junior Male Handball Players
Authors: Aloui Ghaith , Hammami Mehrez , Fathloun Mourad , Hermassi Souhail , Gaamouri Nawel , Shephard Roy J. , Chelly Mohamed Souhaiel
Published: September 2018

Aloui, G, Hammami, M, Fathloun, M, Hermassi, S, Gaamouri, N, Shephard, RJ, and Chelly, MS. Effects of an 8-week in-season elastic band training program on explosive muscle performance, change of direction, and repeated changes of direction in the lower limbs of junior male handball players. J Strength Cond Res 33(7): 1804–1815, 2019—The aim of this study was to examine the effects of incorporating 8 weeks of biweekly lower-limb elastic band training (knee and hip extension) into the in-season regimen of junior handball players. Study participants (30 men, aged 18.7 ± 0.8 years, body mass 81.1 ± 15.4 kg, height 1.82 ± 0.06 m, body fat: 15.5 ± 5.2%) were randomly assigned between control and experimental groups. Measures obtained before and after intervention included a cycle ergometer force-velocity test, force platform determinations of squat and countermovement jump characteristics, sprint times (5 and 30 m), repeated change-of-direction (RCOD) and change-of-direction (T-half, COD) tests, 1 repetition maximum (RM) half back squat, and anthropometric estimates of limb muscle volumes. Small to trivial improvements of experimental subjects relative to control subjects included peak power (p < 0.001), 1RM strength measures (p < 0.01), sprint times (p < 0.001 for 5 m; p < 0.05 for 30 m), COD (p < 0.01), and all RCOD parameters (p < 0.05) except the RCOD fatigue index. However, vertical jump parameters and limb volumes remained unchanged relative to controls. It may be concluded that adding biweekly elastic band training to a standard conditioning regimen yields small gains in measures that likely have an important influence on handball performance, particularly the ability to sprint, change direction, and make repeated changes of direction. Accordingly, such simple exercises can usefully be adopted as a component of handball training.
Nordic Hamstring Strength of Highly Trained Youth Football Players and Its Relation to Sprint Performance
Authors: Markovic Goran , Sarabon Nejc , Boban Frane , Zoric Ivan , Jelcic Mario , Sos Kresimir , Scappaticci Mark
Published: September 2018

Markovic, G, Sarabon, N, Boban, F, Zoric, I, Jelcic, M, Sos, K, and Scappaticci, M. Nordic hamstring strength of highly trained youth football players and its relation to sprint performance. J Strength Cond Res 34(3): 800–807, 2020—We aimed to characterize Nordic hamstring (NH) strength and bilateral NH strength asymmetry in highly trained youth footballers and to investigate the relationship between NH strength and sprint performance. Twenty-two adult and 133 highly trained youth footballers in the age groups U12–U18 participated in this study. Eccentric hamstring strength was assessed using the NH device. Youth footballers (n = 119) also performed 20-m sprint test. Age-related changes in absolute and relative NH strength, and bilateral NH strength asymmetry were analyzed using 1-way analysis of variance. The linear relationship between relative NH strength and sprint performance was established using a Pearson correlation analysis. Significant age-related increases (F = 3.6–18.9; all p < 0.01) in NH strength were reported for all units except N·kg−1 (F = 1.9; p = 0.08). The largest differences in absolute NH strength were seen between U15 and U16 groups. Bilateral NH strength asymmetry varied from 8 to 16% (F = 1.8; p = 0.09) across all age groups. A large correlation between NH strength and sprint performance was observed (r = −0.52; p < 0.01). Our results indicate that NH strength increases nonlinearly with players' age, with the highest values observed in U16 group. Furthermore, bilateral NH strength asymmetry varied nonsignificantly between 8 and 16%. Finally, 27% of variance of sprint performance of youth footballers could be explained by relative NH strength. The reported NH strength data could be used as normative standards during testing and training of youth football players. Present results also suggest that coaches should pay close attention to eccentric hamstring function in youth footballers.
Divergent Blood Pressure Response After High-Intensity Interval Exercise: A Signal of Delayed Recovery?
Authors: Hunter Gary R. , Fisher Gordon , Bryan David R. , Borges Juliano H. , Carter Stephen J.
Published: September 2018

Hunter, GR, Fisher, G, Bryan, DR, Borges, JH, and Carter, SJ. Divergent blood pressure response after high-intensity interval exercise: a signal of delayed recovery? J Strength Cond Res 32(11): 3004–3010, 2018—The objective of this commentary is to highlight potential factors influential to the adaptation of high-intensity exercise. Herein, we present a rationale supporting the contention that elevated systolic blood pressure, after a bout of high-intensity exercise, may be indicative of delayed/incomplete recovery. Relative to type I skeletal muscle fibers, the unique cellular/vascular characteristics of type II muscle fibers may necessitate longer recovery periods, especially when exposed to repeated high-intensity efforts (i.e., intervals). In addition to the noted race disparities in cardiometabolic disease risk, including higher mean blood pressures, African Americans may have a larger percentage of type II muscle fibers, thus possibly contributing to noted differences in recovery after high-intensity exercise. Given that optimal recovery is needed to maximize physiological adaptation, high-intensity training programs should be individually-tailored and consistent with recovery profile(s). In most instances, even among those susceptible, the risk to nonfunctional overreaching can be largely mitigated if sufficient recovery is integrated into training paradigms.
Resistance Training Performed With Single and Multiple Sets Induces Similar Improvements in Muscular Strength, Muscle Mass, Muscle Quality, and IGF-1 in Older Women: A Randomized Controlled Trial
Authors: Cunha Paolo M. , Nunes João Pedro , Tomeleri Crisieli M. , Nascimento Matheus A. , Schoenfeld Brad J. , Antunes Melissa , Gobbo Luis Alberto , Teixeira Denilson , Cyrino Edilson S.
Published: September 2018

Cunha PM, Nunes JP, Tomeleri CM, Nascimento MA, Schoenfeld BJ, Antunes M, Gobbo LA, Teixeira D, and Cyrino ES. Resistance training performed with single and multiple sets induces similar improvements in muscular strength, muscle mass, muscle quality, and IGF-1 in older women: A randomized controlled trial. J Strength Cond Res 34(4): 1008–1016, 2020—The purpose of this study was to compare the effects between single set vs. multiple sets of resistance training (RT) on measures of muscular strength, muscle mass, muscle quality (MQ), and insulin-like growth factor 1 (IGF-1) in untrained healthy older women. Sixty-two older women were randomly assigned to 1 of the 3 groups: single-set RT (SS, n = 21), multiple-sets RT (MS, n = 20), or nontraining control (CG, n = 21). Both training groups performed RT for 12 weeks, using 8 exercises of 10–15 repetitions maximum for each exercise. The SS group performed only 1 set per exercise, whereas MS performed 3 sets. Anthropometry, muscle strength (1RM tests), lean soft tissue (LST), and MQ from upper limbs (UL) and lower limbs (LL), and IGF-1 were measured before and after training. Both training groups showed significant pre-training to post-training increases for UL1RM (SS: 37.1%, MS: 27.3%, CG: −3.0%), LL1RM (SS: 16.3%, MS: 21.7%, CG: −0.7%), ULLST (SS: 7.8%, MS: 8.8%, CG: −1.1%), LLLST (SS: 5.6%, MS: 6.3%, CG: −0.8%), upper-limb muscle quality (SS: 25.2%, MS: 16.7%, CG: −0.2%), lower-limb muscle quality (SS: 10.5%, MS: 15.4%, CG: −3.5%), and IGF-1 (SS: +7.1%, MS: +10.1%, CG: −2.2%). We conclude that both SS and MS produce similar increases in muscular strength, LST, and MQ of upper and lower limbs, and IGF-1 after 12 weeks of RT in untrained older women. Our results suggest that, in the early stages, the RT regardless number of sets is effective for improving muscular outcomes in this population.
Maximal Strength Training Improves Strength Performance in Grapplers
Authors: Øvretveit Karsten , Tøien Tiril
Published: September 2018

Øvretveit, K and Tøien, T. Maximal strength training improves strength performance in grapplers. J Strength Cond Res 32(12): 3326–3332, 2018—The aim of this study was to assess the short-term effects of maximal strength training (MST) as an accessory to grappling training on strength performance in competitive Brazilian Jiu-Jitsu (BJJ) athletes. Fourteen male BJJ athletes underwent measurements of 1 repetition maximum (1RM) in the squat and bench press, rate of force development (RFD) and peak force (PF) in the squat jump, countermovement jump (CMJ) height, and muscular endurance in pull-ups, sit-ups, and push-ups. After baseline measurements, subjects were randomly allocated to either an MST group or control group (CON). The MST intervention consisted of 4 × 4 repetitions at ≥ 85% of 1RM in the squat and bench press, and 4 sets of pull-ups to failure, performed 3× per week. Both groups were instructed to maintain their BJJ training and avoid additional strength training. Maximal strength training improved 1RM in the squat and bench press by 15 ± 9% (p = 0.02) and 11 ± 3% (p = 0.03), respectively, and CMJ height by 9 ± 7% (p = 0.04). Muscular endurance performance increased by 33 ± 33% in pull-ups (p = 0.03), 32 ± 12% in push-ups (p = 0.03), and 13 ± 13% in sit-ups (p = 0.03). Increases in RFD (35 ± 55%, p = 0.13) and PF (8 ± 9%, p = 0.09) did not reach significance. No improvements were apparent from BJJ training alone (p > 0.05). These findings suggest that MST is a potent approach to rapid improvements in maximal strength, power, and muscular endurance in active grapplers.
AMINAS BIOGÊNICAS EM PESCADO: OCORRÊNCIA, RELEVÂNCIA E DETECÇÃO
Authors: Veiga Filho Irval Leonel , De Mesquita Eliana de Fátima Marques
Published: September 2018

O segmento da pesca industrial no Brasil é de grande relevância social e econômica para muitos municípios litorâneos. Trata-se de uma atividade de base, fornecedora de matéria prima para as grandes indústrias e centros de distribuição de alimentos. Apesar de suas excelentes qualidades nutricionais, o consumo de pescado no Brasil ainda é baixo, se comparado ao de outros países. Em relação às questões de saúde pública, as preocupações têm sido principalmente voltadas à presença de agentes etiológicos de doenças alimentares. Por outro lado, diversos são os perigos de natureza química que podem estar presentes nos alimentos e, alguns têm sido descritos como inerentes ao próprio processo de transformação de matéria-prima em produto, como é o caso das aminas biogênicas, que podem atingir altos níveis quantitativos a ponto de se tornarem um risco para a saúde do consumidor. O pescado está mais associado aos casos de intoxicação por aminas biogênicas do que outros alimentos, com destaque às ocorrências causadas pela ingestão de histamina. A ausência de métodos para eliminação das aminas biogênicas nos alimentos, incluindo o pescado, faz da prevenção, a metodologia mais eficaz para reduzir os riscos de intoxicação. Portanto o trinômio “Tempo, higiene e temperatura” torna-se essencial para assegurar a qualidade do pescado. A quantificação de aminas biogênicas no pescado pode ser considerada uma excelente ferramenta para auxiliar na determinação da qualidade desse alimento.
UMA BREVE ABORDAGEM SOBRE AS DISPERSÕES SÓLIDAS
Authors: De Sales Daniel Lins , Motta Adriana Cristina , Marcomini André Luís , Beatrice Cesar Augusto Gonçalves , Franco Pedro Henrique Da Rocha , Dantas Fábio Moysés Lins , Da Rocha-Leão Maria Helena Miguez
Published: September 2018

Aumentar a biodisponibilidade oral de formas farmacêuticas sólidas com fármacos fracamente solúveis tem sido um grande desafio para as indústrias farmacêuticas nos últimos tempos. Diante desta problemática, sistemas com dispersões sólidas têm fornecidos bons resultados.  Tal assunto tem sido de grande relevância para as ciências farmacêuticas, no entanto, na atualidade, a literatura nacional carece de informações a respeito dos recentes avanços, principalmente, no tocante a técnica promissora de preparação chamada de Hot melt extrusion. Em vista disso, o intuito desta revisão é contextualizar a importância da solubilidade para a biodisponibilidade oral, conceituar e classificar as dispersões sólidas, abordar modelos matemáticos de miscibilidade fármaco-polímero, apresentar técnicas de preparação e caracterização, além de citar exemplos de produtos comercializados proveniente da tecnologia de HME.
MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing ofOprm1andKcna2Genes in Primary Sensory Neurons
Authors: Mo Kai , Wu Shaogen , Gu Xiyao , Xiong Ming , Cai Weihua , Atianjoh Fidelis E. , Jobe Emily E. , Zhao Xinyu , Tu Wei-Feng , Tao Yuan-Xiang
Published: September 2018

The transmission of normal sensory and/or acute noxious information requires intact expression of pain-associated genes within the pain pathways of nervous system. Expressional changes of these genes after peripheral nerve injury are also critical for neuropathic pain induction and maintenance. Methyl-CpG-binding domain protein 1 (MBD1), an epigenetic repressor, regulates gene transcriptional activity. We report here that MBD1 in the primary sensory neurons of DRG is critical for the genesis of acute pain and neuropathic pain as DRG MBD1-deficient mice exhibit the reduced responses to acute mechanical, heat, cold, and capsaicin stimuli and the blunted nerve injury-induced pain hypersensitivities. Furthermore, DRG overexpression of MBD1 leads to spontaneous pain and evoked pain hypersensitivities in the WT mice and restores acute pain sensitivities in the MBD1-deficient mice. Mechanistically, MDB1 repressesOprm1andKcna2gene expression by recruiting DNA methyltransferase DNMT3a into these two gene promoters in the DRG neurons. DRG MBD1 is likely a key player under the conditions of acute pain and neuropathic pain.

SIGNIFICANCE STATEMENTIn the present study, we revealed that the mice with deficiency of methyl-CpG-binding domain protein 1 (MBD1), an epigenetic repressor, in the DRG displayed the reduced responses to acute noxious stimuli and the blunted neuropathic pain. We also showed that DRG overexpression of MBD1 produced the hypersensitivities to noxious stimuli in the WT mice and rescued acute pain sensitivities in the MBD1-deficient mice. We have also provided the evidence that MDB1 repressesOprm1andKcna2gene expression by recruiting DNA methyltransferase DNMT3a into these two gene promoters in the DRG neurons. DRG MBD1 may participate in the genesis of acute pain and neuropathic pain likely through regulating DNMT3a-controlledOprm1andKcna2gene expression in the DRG neurons.
Obesity, fertility and pregnancy: can we intervene to improve outcomes?
Authors: Reynolds Rebecca M , Gordon Adrienne
Published: September 2018

Rates of obesity among women of reproductive age have risen dramatically in recent decades. Obesity impacts on health of women across their reproductive lifespan with adverse effects on not only fertility and short-term complications of pregnancy, but also on longer term health outcomes for both women and their children. This places considerable burden and cost on health services. Here, we review the evidence linking maternal obesity to adverse fertility, pregnancy and longer term health outcomes for women and their children. We discuss the outcomes of recent lifestyle, pharmacological and surgical intervention studies. As many of these studies have not shown a significant improvement in clinical outcomes, we discuss the need for better study design in future trials.
Organized Hemopericardium Mimicking Malignant Tumor: A Case of Spontaneous Pericardial Hematoma In a 23-Year-Old Young Male
Authors: Wang Wenda , Miao Qi
Published: September 2018

Spontaneous pericardial hematoma is rare, and the diagnosis of spontaneous organized hemopericardium is difficult in some cases. The present study reports a case of a 23-year-old man admitted to our hospital for dyspnea on Sept. 30, 2017. The patient experienced shortness of breath 10 days before admission and went to a local hospital. The chest non-contrast CT and Echo revealed effusion of pericardium, right thoracic cavity and abdominal cavity. The patient went to our hospital for further treatment, and there was no abnormality in the laboratory tests of infection, tumor, or immune disease. The patient received pericardiocentesis for cardiac tamponade. A re-examination of Echo after pericardiocentesis revealed a pericardial mass. The enhanced chest CT and 18F-FDG PET/CT could not rule out the risk of a malignant tumor. The resection of pericardial mass was performed under cardiopulmonary bypass with cardioplegia. The pathology was organized hematoma with widely hemorrhage and necrosis, fibrous tissue proliferation, myofibroblast proliferation, and granulation tissue formation. The patient was discharged from our hospital without recurrence of pericardial effusion or the symptom of dyspnea. This case suggests that spontaneous organized hemopericardium is difficult to be distinguished from malignant tumor, and a surgical resection can help with diagnosis and symptomatic relief.
The Community of Inquiry as a Framework in Student Teachers’ Music Education
Authors: Enbuska Jukka , Tuisku Vesa , Hietanen Lenita
Published: September 2018

Music education today seeks to respond to the changing demands of 21st century learners (Portowitz et al. (2014). Today’s music educators face a great challenge how best to take advantage of the digital music technology in music education, involving students with different musical backgrounds, with the different readiness of music technology and how digital music technology can be used in different learning environments. Blended learning provides solutions on how to create e-learning environments and how to make them useful for students as well as teachers. The teaching in this project, is based on the idea of community of inquiry (CoI) introduced by Garrison (2017) and the research at hand asks what kind of possibilities will the community of inquiry framework offer in student teachers’ music education in the blended learning environment. The data consist of 19 students’ written communications with the teacher. The analysis started as data-based, by searching to find out what the data tells us, then continued as theory-guided content analysis. Referring to Dana and Dumez (2015) and using both inductive and, to some extent, deductive approaches, this study’s research strategy followed the logic of content analysis. The analysis is completed as theory-guided content analysis (Krippendorff, 2004). The methodological approach is mainly qualitative and constructive, which allows for an open-ended view of the data and even unexpected results (Kasanen et al., 1993). This research reveals that in studying music in the blended learning environment from the perspective of community of inquiry, there are students who are knowledgeable, students who have sight-reading problems, students who notice the progress of one’s playing skills, students who do not give up and students who have ability to face challenges.
Effects of Nintendo Wii® Program in Dual-Task Performance in Older Adults
Authors: Rodrigues Abel , Pinheira Vítor , Coutinho António , Leitão Catarina , Monteiro Ana , Henriques Elsa
Published: September 2018

A sedentary lifestyle has a strong impact on the older population; so participation in physical activity is important for enhanced physical and mental function, increasing health and well-being. In the elderly, dual- task activities are severely impaired which is why the Nintendo Wii® may be an important tool to maintain the proper functioning of the physical and mental levels among the elderly. This study sought to determine the effect of Nintendo Wii® training on dual-task performance, cognition, balance confidence, the health status and instrumental performances of daily life activities in older adults. A total of 18 participants aged 75.17±8.86 years were included. All participants were women, retired and living in their own residence. The training included a 15-minute exercise session using Wii®Fit twice a week for 8 weeks. The group was measured before and after the intervention (T0 and T1) and in 3 and 6 months follow-up (T2 and T3). Social demographic factors were assessed at T0 and T3. Cognition, general health status, confidence in balance, performance of instrumental activities of daily life, dual and multi-task performances were assessed at all evaluation moments. The mental component of health status and experimental protocol between T0 and T1 showed a statistically significant improvement. In T2 and T3 interval, there was a significant improvement in mental health status. From the baseline to T1, participants showed a statistical significant improvement in the mental component of health status and in experimental dual-task protocol. It can be concluded that the Nintendo Wii®Fit training program significantly improved dual and multi-task performances among older adults.
Pengaruh Dukungan Sosial Dan Forgiveness Terhadap Kekerasan Seksual Pada Remaja
Authors: Faizah Nur , Layyinah Layyinah
Published: September 2018

This study aimed to determine the effect of social support and forgiveness to sexual violence in adolescent. Samples were victim of sexual violence in social institution under the auspices of the Ministry of Social Affairs in Jakarta, as many as 92 people. There are 3 measuring instrument used in this study, namely Betrayal Trauma Inventory (BTI), Interpersonal Support Evaluation List (ISEL) and Transgression-Related Interpersonal Motivation (TRIM-14). The sampling technique used non-probability sampling. Analysis of the data used multiple regression analysis at 0.05 significance level. Based on the hypothesis testing obtained R2 value of 17.7%. This means that the effect of the independent variable on the dependent variable is equal to 17.7% while 82.3% are influenced by other variables. Based on the sig. obtained sig. 0.002 which means that there is a significant effect of social support (appraisal support, tangible assistance, emotionalsupport, informational support) and forgiveness (avoidance motivation, revenge motivation, and benevolence motivation). DOI: 10.15408/tazkiya.v20i2.9169
The Effect Of Mastery Learning On Affective Characteristics Of Students A Quantitative Research Synthesis
Authors: Hayat Bahrul
Published: September 2018

Many experimental researches have been conducted until recent years to see the effect of mastery learning approach on students’ cognitive behavior and affective characteristics. But the question is how much evidence is there in the existing research results provides scientific conclusions by combining existing experimental results. By treating different experiments of mastery learning as research replications, the experimental results can be combined using a meta-analysis technique. This paper shows how a quantitative research synthesis can effectively be used to combine statistical evidences of researches conducted separately and independently. The effect of mastery learning on affective characteristics of students was selected for this research synthesis. The mastery learning approach to be investigated in this research synthesis is Bloom type of mastery learning strategy. Using 26 independent comparisons, the results of study show that: a) the effect sizes of mastery learning on affective characteristics of students are heterogeneous across studies, b) the source of study, either from dissertation or journal article, does not explain the variability among the effect sizes, c) mastery learning programs using a ≥ 75% mastery criterion seem to have positive affective impact on the students, while those using < 75 % mastery criterion have no impact on the affective characteristics of students, d) the mean effect size shows a decreasing trend as the level of education increases, e) the mean effect size is highly positive for mathematics class and low positive effect for science and social studies, and f) short treatment duration has a much larger positive effect size than the long term treatment duration. DOI: 10.15408/tazkiya.v20i2.9176
Recent Developments in Atopic Dermatitis
Authors: Yang Eric J. , Sekhon Sahil , Sanchez Isabelle M. , Beck Kristen M. , Bhutani Tina
Published: September 2018

Atopic dermatitis (AD) is a bothersome and common skin disease affecting ∼10.7% of children in the United States. This skin condition significantly decreases quality of life in not only patients, but in their families as well. Pediatricians are often the first physicians to diagnose and manage these patients and thus are relied on by families to answer questions about this disease. AD is complex, multifactorial, and has historically had limited therapeutic options, but the landscape of this disease is now rapidly changing. Pathways contributing to the pathogenesis of this disease are continually being discovered, and new therapies for AD are being developed at an unprecedented rate. With this article, we will review the current guidelines regarding the management of AD, outline updates in the current understanding of its pathophysiology, and highlight novel developments available for the treatment of this burdensome disease.
Mobilização de Recursos e Identidade: a Ação Coletiva em uma ONG
Authors: De Queiroz-Stein Guilherme
Published: September 2018

Neste artigo, exploram-se complementaridades entre a Teoria da Mobilização de Recursos e a noção de Identidade, considerando que ambas fornecem instrumentos conceituais importantes para se analisar processos de ação coletiva. Dessa perspectiva, investigam-se as estratégias organizativas em uma entidade associativa que se reconhece e é reconhecida como uma ONG, o Centro de Assessoria Multiprofissional (CAMP), localizada em Porto Alegre. Os dados utilizados foram coletados em pesquisa de campo realizada entre 2010 e 2011, através de entrevistas, observação participante e análise orçamentária. Os resultados mostram mudanças nas estratégias de mobilização de recursos, de modo que fontes estatais e empresariais passaram a predominar, legando menor peso à cooperação internacional. Isso implicou em tensões identitárias, especialmente no que se refere à autonomia de atuação da entidade.
Characteristics and Trends of Saudi Tourists in the Kingdom of Bahrain
Authors: Alsamawi Habis
Published: September 2018

The data of this study were based on a survey of the Saudi tourist movement in Bahrain, which included 14993 samples. The results of this study indicate that there are significant statistical indications with most of the study variables, while the results showed that there are several motives for the Saudi tourists to visit Bahrain, including shopping (45.8%), leisure and recreation (23.8%), health and relaxation (11.5%). The sample members were influenced by the opinions of newspapers, magazines and advertising publications (45.9%). in addition to the opinion of relatives and friends on the decision to choose Bahrain for their tourist destination. Tourist’s satisfaction showed a high degree with catering services, cafes, shopping, security Stability and Bahraini hospitality, and even their evaluation of tourist satisfaction in general was distinguished by 85.2%, but in return there are some services have created some resentment among tourists such as facilities provided on King Fahd Causeway and Taxi services, car rental, and leisure activities. The most important findings and recommendations of the study are the need to facilitate travel procedures on King Fahd Causeway, with satisfaction (48%) and expand the establishment of recreational activities (68%), and develop the role of exhibitions and events in attracting tourists
Eco-criticism: A comparative study of Madrid Deforestation and its Effect on Secondary School Student’s learning performance in jalingo and Ardo kola local Government areas of Jalingo, Taraba State of Nigeria.
Authors: Karfe Dr. Abigail Seth
Published: September 2018

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VAKSIN KERING BEKU SEL UTUH BAKTERI Aeromonas hydrophila UNTUK PENCEGAHAN PENYAKIT MOTILE AEROMONADS SEPTICEMIA PADA IKAN LELE, NILA, DAN GURAMI
Authors: Sugiani Desy , Taukhid Taukhid , Purwaningsih Uni , Lusiastuti Angela Mariana
Published: September 2018

Vaksinasi merupakan salah satu cara yang efektif untuk pencegahan penyakit infeksius pada budidaya ikan. Produk vaksin yang tersedia saat ini masih berbasis produk cair (water based vaccines), yang memiliki kekurangan dalam stabilitas produk yang tidak tahan lama jika disimpan dalam suhu ruang dan keterbatasan dalam tranportasi. Penelitian ini bertujuan untuk mengembangkan metode preparasi sediaan produk vaksin sel utuh Aeromonas hydrophila dalam bentuk kering beku (freeze dried) untuk pengendalian penyakit pada ikan lele (Clarias sp.), nila (Oreochromis niloticus), dan gurami (Osphronemus gouramy). Penelitian dilakukan dengan membuat produk vaksin kering beku pada suhu -100°C, uji mutu, uji keamanan, dan uji efikasi. Penelitian ini telah menghasilkan produk vaksin kering beku yang aman diaplikasikan pada ikan lele, nila, dan gurami, serta dapat menginduksi peningkatan level titer antibodi. Sediaan vaksin sel utuh A. hydrophila dengan metode kering beku dapat mereduksi berat produk vaksin cair 100 g menjadi serbuk sebesar 4,2 g. Efikasi vaksin menghasilkan tingkat sintasan relatif (RPS/relative percent survival) pada ikan nila (Oreochromis niloticus) 45,83%; ikan lele (Clarias sp.) 70%; dan ikan gurami (Osphronemus gouramy) 31,67%. Vaksin kering beku sel utuh bakteri Aeromonas hydrophila paling efektif diberikan pada ikan lele untuk mencegah penyakit Motile Aeromonads Septicemia.Vaccination is one of the most effective methods to prevent disease outbreaks and distribution in aquaculture. Commercial fish vaccine products are mainly available in liquid-based products (water-based vaccines), which have several limitations such as stability issues of the products (durability) when stored at room temperature, bulky packaging, and transportation complexity during distribution. This study aimed to develop a method of vaccine preparation using the freeze-dried method as part of the management control of Aeromonads septicemia disease in freshwater aquaculture. The study consisted of several stages: the first stage was the production of freeze-dried Aeromonas hydrophila vaccine product at -100°C. The second stage was vaccine quality test followed by the third stage which was vaccine efficacy test. This research produced frozen dried vaccine products that were considered safe to be applied to catfish, tilapia, and gourami, and could increase the antibody titer. The formation of the whole cell vaccine of A. hydrophila using the freeze-dried method could reduce the weight of the liquid form of the vaccine product from 100 g to a powder weighing only 4.2 g. The results of the vaccine efficacy test showed the relative percent survivals (RPSs) of Clarias sp., Oreochromis niloticus and Osphronemus gouramy were 70%, 45.83%, and 31.67%, respectively. Freeze dried vaccine of whole cells Aeromonas hydrophila are most effective in catfish to prevent Motile Aeromanads Septicemia.
PLANEJAMENTO PARA A ATUAÇÃO COM A EDUCAÇÃO FÍSICA ESCOLAR: REFLEXÕES A PARTIR DO PROGRAMA INSTITUCIONAL DE BOLSA DE INICIAÇÃO A DOCÊNCIA- PIBID- CEFD/UFSM
Authors: Patias Bhianca Conterato , Ivo Andressa Aita , Da Costa Leandra Costa , Marin Elizara Carolina
Published: September 2018

Este trabalho tematiza o planejamento, objetivando compreender a elaboração e desenvolvimento do planejamento para ação docente com a Educação Física (EF) no contexto do PIBID EF do CEFD/UFSM. Para levantamento dos dados foi realizado entrevistas com doze bolsistas, seis supervisores e dois coordenadores. Os dados demonstraram que apesar de historicamente o planejamento pedagógico na EF escolar possuir fragilidades e, por vezes se resumir ao cumprimento de obrigações burocráticas, no contexto do subprojeto PIBID Educação Física o planejamento tem assumido relevância nas reuniões e na ação docente dos envolvidos.
ALTERIDADE, O OUTRO E A APRESENTAÇÃO DA NOÇÃO DE SUBJETIVIDADE EM EMMANUEL LEVINAS
Authors: Mendonça Roberta Rayza Silva de , Cardoso Fernando da Silva
Published: September 2018

O presente trabalho problematiza o pensamento do filósofo lituano Emmanuel Levinas, procurando entender o conceito apresentado como o Outro a partir das noções de alteridade e subjetividade. Discute-se os argumentos do autor como intersecções a pensar a ideia de humano, e, também, sobre como a ideia de alteridade está relacionada ao reconhecimento do Outro que Levinas nos apresenta. O trajeto metodológico, de caráter bibliográfico-exploratório, perfaz o aprofundamento e a apresentação de reflexões acerca do humano enquanto ente responsável, importantes à construção da noção de subjetividade levinasiana aqui apresentada.
A PRODUÇÃO ACADÊMICA DA FORMAÇÃO DE PROFESSORES NA EDUCAÇÃO PROFISSIONAL
Authors: Said Pierre Carneiro Isabel Magda , Dias Cavalcante Maria Marina
Published: September 2018

Este trabalho apresenta o cenário da produção acadêmica brasileira sobre a formação de professores da Educação Profissional e Tecnológica (EPT). O mapeamento dos trabalhos acadêmicos foi realizado, em setembro/2014, no banco de dados de dissertações e teses do portal da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), nas reuniões anuais da Associação Nacional de Pós-Graduação e Pesquisa em Educação (ANPED) e nos Encontros de Didática e Prática de Ensino (ENDIPE). Em relação ao recorte temporal, definimos o período entre 2005 e 2014. Os estudos analisados destacam a importância das instituições de ensino criarem espaços de formação continuada, assumindo a responsabilidade de sustentar o desenvolvimento profissional dos professores e reforçam a necessidade de uma base epistemológica e metodológica fundamentar essa formação.
ANÁLISE DE POLÍTICAS PÚBLICAS: uma breve revisão de aspectos metodológicos para formulação de políticas
Authors: Estevão Renildo Barbosa , Ferreira Maria D'Alva Macedo
Published: September 2018

É objetivo deste artigo apresentar uma reflexão acerca da Análise de Política Pública. Para tanto, recorre-se à literatura relativa à formulação de política pública e sua agenda, bem como do processo de tomada de decisão. Inicialmente, apresenta-se uma ideia simplificada de sistema político, com suas demandas, decisões e ações, utilizando-se como cenário, o modelo sistêmico. Em seguida,  abordam-se as influências que as relações entre Estado e sociedade trazem para as políticas públicas e as visões do Estado que buscam explicar essas relações. No ponto seguinte, conceitua-se análise de políticas, bem como esclarecem-se seus objetivos. Num quarto momento, são expostos os modelos de tomada de decisão relevantes à formulação da política. Por fim, apresenta-se o papel das organizações na formulação da política.  Assim, foi possível explorar aspectos essenciais para se verificar o processo de construção da política pública e por que determinada política entra na agenda pública, destacando-se "um estudo da elaboração das políticas", onde as atenções se voltam à fase da formulação da política pública.
THE FORMATION OF BRAZILIAN MINERALS DATABASE FOR INTEGRATED SEM-EDS SYSTEM APPLIED TO THE GOLD ORE CHARACTERIZATION
Authors: Sampaio Ney Pinheiro , Araújo Fernando Gabriel , Von Kruger Fernando Leopoldo
Published: September 2018

The mineralogical characterization of the various Brazilian occurrence of minerals is presented as one of the key steps in the design of the minerals processing route and improving the overall efficiency of the process. Such information is essential in assessing the technical and economic viability of a mineral Project. Among the various mineralogical characterization techniques, automated analyzers are gaining great prominence because they provide qualitative and quantitative data in an automated manner, with great speed and accuracy. The system, available in NanoLab, laboratory of the Mining-Metallurgic Centre REDEMAT, specifically called TIMA-MIRA, is composed of a scan control program and analysis of mineral data (TIMA - Tescan Integrated Mineral Analyzer) and a scanning electron microscope with cannon field emission of electrons associated with two energy dispersive detector characteristic X-rays (MIRA - trade name). The system uses a mineral database in its operations, consisting in the association of images by back scattered electrons of the mineral grains, with their characteristic X-ray spectra and their comparison with the characteristic spectra of a database. The equipment has an interface that allows you to add minerals and other materials to their underlying database, which is critical to the accuracy of the results because the original equipment database, created, only with data of mineral samples from other countries, does not identify minerals of national origin, with its characteristic major and minor elements. These limitations of the database integrated mineral analyzer TIMA-MIRA motivated the construction of a new database through a selection methodology, preparation and analysis by diffraction rays and the TIMA-MIRA system, different context samples Brazilian geological. With the XR diffraction analysis, each mineral was determined to be analyzed in the integrated mineral analysis system. With this, we obtained the maximum and minimum values of the intensities of chemical elements peaks that make up the analyzed mineral, obtaining thus new identification rules for each selected species and adapted some existing rules, to meet the needs presented
PERFIL E PERCEPÇÕES SOBRE A PRÁTICA PEDAGÓGICA DO PROFESSOR BACHAREL NA EDUCAÇÃO PROFISSIONAL
Authors: Oliveira Jamille De Amorim , Silva Yara Fonseca de Oliveira e
Published: September 2018

O presente trabalho é um recorte da proposta de pesquisa de mestrado que discute as concepções de alguns professores bacharéis sobre suas práticas pedagógicas e analisa se nessas práticas docentes contemplam os elementos e os conceitos da abordagem sociocultural de Vygotsky. A pesquisa está fundamentada pelos estudos de Veiga (1992) para tratar sobre a prática pedagógica, e pelas contribuições de Vygotsky (2007), Masetto (2000), Figueiredo (2006) ao contemplar os conceitos centrais de Zona de Desenvolvimento Proximal (ZDP), Mediação e Aprendizagem Colaborativa, entre outros. A metodologia utilizada é de abordagem qualitativa, tendo a entrevista semiestruturada como instrumento de coleta de dados. Os sujeitos investigados são quatro professores de um Câmpus da Rede Federal de Ensino do Estado de Goiás que atuam na Educação Profissional Básica. Os resultados da pesquisa evidenciam que apesar da predominância de uma prática pedagógica repetitiva desenvolvida por esses professores, há, também, a presença dos elementos/conceitos da abordagem sociocultural de Vygotsky em algumas situações nas aulas desses professores bacharéis contemplando a interação social com atividades colaborativas, uso dos scaffoldings, propiciando assim, a execução da ZPD do aluno. Todavia, os elementos da teoria sociocultural externados por esses professores é algo aleatório desenvolvido por eles, sem objetivos pedagógicos preestabelecidos, baseados apenas nas suas próprias bagagens culturais.