bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new
Authors: Farmanlı Gülnar , Ilgın Sinem , Ergun Bülent , Baysal Merve , Karaduman Abdullah Burak , Atlı Eklioğlu Özlem
Published: August 2023

Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the liver. The available data are based solely on published case reports. For this reason, this study aims to evaluate the hepatotoxicity of carbamazepine and perampanel, which are frequently used in treating epilepsy and which do not have a detailed investigation, although they are suspected of hepatotoxicity. Hepatotoxicity in the HepG2 cell line, IC50 values were calculated by MTT cytotoxicity test, followed by determination of apoptosis/necrosis, various biochemical analyzes (ALT, AST, urea), which is currently a biomarker for liver injury, and hepatotoxicity by ROS and GSH determination. Both drugs increased liver biomarkers, oxidative stress, and cytotoxicity in HepG2 cells. The investigation found that the drugs triggered liver apoptosis, not necrosis. In conclusion, Perampanel may have hepatotoxicity similar to carbamazepine.
Understanding “Honour”-Based Abuse and Safeguarding Victim-Survivors
Authors: Walizadeh Elaha
Published: August 2023

Over the course of the year ending March 2022, England and Wales recorded a total of 2,887 cases of so called “honour”-based abuse (HBA). This was a 6% increase over the previous year’s figures, indicating that this unfortunate phenomenon is on the rise. HBA predominately affects women and girls and with a concerted multiagency approach and prioritisation of survivors’ safety, it can be prevented. This article explores some of the most prominent cases of HBA in the last two decades and provides guidance on how midwives and students can best support victim-survivors.
TOKOPHOBIA: MORE THAN FEAR OF CHILDBIRTH
Authors: Bhambra Suman
Published: August 2023

This article provides a comprehensive overview of tokophobia, also referred to as fear of birth. It explains what this condition is, the impact that tokophobia can have on women and birthing people, and emphasises the importance of its early identification. This article aims to raise awareness of tokophobia and recognises the crucial role midwives and students can play in the early identification and management of this condition.
Paramètres technico économique de la chèvre locale en élevage intégré dans les fermes irriguées des zones arides
Authors: Atoui Ahlem , Aicha Laaroussi , Abdennebi Mouldi , Ben Salem Farah , Najari Sghaier
Published: August 2023

La population caprine locale est une ressource génétique adaptée à l’élevage pastoral des régions arides. L’intégration agro écologique de l’élevage caprin fournit au cheptel les conditions d’intensification de la conduite du cheptel élevé en stabulation. Le mode de gestion zootechnique et économique du troupeau, dans ce système d’élevage fixe, doit synthétiser les apports des différents facteurs de production et leur valorisation par les performances animales. L’ensemble des paramètres technico économiques à établir, pour chaque campagne, doivent illustrer les résultats de l’exercice et permettre l’évaluation des étapes de production afin d’améliorer les modes de la conduite et des performances du troupeau. Un modèle de synthèse des résultats zootechniques du troupeau caprin a été adopté à la ferme expérimentale d’d’El GORDHAB. Un total de 89 chèvres mises à la lutte, et 8 boucs, ont donné naissance à 128 chevreaux. Le taux de fertilité, le taux de mortalité des chevreaux à la naissance, l’intervalle entre deux mises bas successives et la taille de la portée ont été respectivement de 91% ;3% ; 9,86mois et 1,60chevreaux ; qui sont largement supérieur à ceux connus de la chèvre locale en élevage pastoral sur parcours. La chèvre locale a pu améliorer ses performances de production numérique et de reproduction dans les conditions intensives, ce qui ouvre la porte pour le développement intégré de l’élevage caprin dans les fermes irriguées du sud tunisien.
Human Capital Management in a highly competent environment – public administration
Authors: Jurek Krzysztof
Published: August 2023

In the era of ever greater progress as well as the development of competences and broadening horizons, it is natural that access to specialized staff is more and more transparent than a few or several years ago. Increasingly galloping inflation and challenges that face all kinds of enterprises as well as the labor market itself, high competences begin to play a greater role in proper and proper management. The challenges brought by 2022 can be called, in a sense, the accumulation of the last several years. Why cumulative? First of all, attention should be paid to the conflict between Russia and Ukraine, which has been bubbling between the two countries for many years. It reached its climax on February 24, 2022. The pandemic period also had an impact on the demand for highly competent employees, during which many people increased their qualifications. It should also be mentioned that creative work is a kind of source with a positive value that provides benefits to the company. Institutions should ensure, first of all, appropriate safeguards, including social ones, as well as adequate access to education.
Evolution of the Human Security concept according to Japanese Diplomatic Bluebook
Authors: Kosmalski Bartosz
Published: August 2023

The interest in Human Security somehow arises spontaneously from the constantly dynamizing international reality, dilling a specific gap left by the understanding of national security as a certain ruling absolute in this domain. Among the many definitions and conceptual assumptions, two main ways of perceiving this idea have emerged depending on the reserach subject – a narrow scope related to freedom from fear and a wide scope, i.e. freedom from poverty. And it was this second theory, its development and promotion, established by the Japanese administration, that became the subject of its foreign policy interest since the end of the 1990s. It is important that Japan as a state constitutionaly focused on a peaceful coexistence and renouncing war as a political instrument, had to find an alternative in the security dimension as a result of these provisions.
VAT a działalność pożytku publicznego – wybrane zagadnienia problemowe. Rozliczanie VAT z tytułu transakcji transgranicznych
Authors: Supera Markowska Maria
Published: August 2023

Organizacje pozarządowe1, mimo że z istoty swojej nie są nastawione na zysk, a ich działalność pożytku publicznego co do zasady nie stanowi działalności gospodarczej w rozumieniu przepisów ustawy z dnia 6 marca 2018 r. – Prawo przedsiębiorców2, mogą podlegać w związku z tą działalnością obowiązkowi podatkowemu w zakresie podatku od towarów i usług3. Dotyczy to w szczególności rozliczania VAT z tytułu transakcji transgranicznych. Związane z tym obowiązki mogą być dla organizacji pozarządowych szczególnie uciążliwe z uwagi na często właśnie ich nieprofesjonalny, wolontariacki charakter. Pojawia się też w tym kontekście fundamentalne pytanie, w jakim stopniu te organizacje – wobec wspomnianego nienastawiania na zysk – mogą (powinny?) podlegać pewnemu preferencyjnemu traktowaniu względem „zwykłych” nastawionych na zysk podmiotów, a w jakim stopniu – wobec konieczności m.in. zapewnienia równej konkurencji na rynku (oraz przestrzegania takich zasad podatkowych, jak m.in. zdolność płatnicza, powszechność opodatkowania czy równość) – nie powinno to mieć miejsca. Wybrane zagadnienia problemowe dotyczące prowadzenia działalności pożytku publicznego przez organizacje pozarządowe w kontekście rozliczeń VAT, stanowiące przedmiot analizy w niniejszym i wcześniejszym artykule4, mają stanowić przyczynek do dalszej dyskusji o specyfice i uregulowaniu działalności pożytku publicznego w polskim systemie prawa, w tym w szczególności w kontekście prawnopodatkowym.
Czy akcyza to podatek od luksusu?
Authors: Glumińska-Pawlic Jadwiga
Published: August 2023

Akcyzy są podatkami bardzo starymi, a w zależności od przyjętej koncepcji opodatkowane nimi mogą być produkty pierwszej potrzeby, artykuły luksusowe, a także konsumpcja zbyteczna (szkodliwa). Jednakże opodatkowanie przedmiotów konsumpcji zbędnej i zbytkowej może przysparzać skarbowi znacznych dochodów tylko wówczas, kiedy ich konsumpcja jest szeroko rozpowszechniona. Nie jest rzeczą łatwą zdefiniowanie „zbytku”, bo to, co kiedyś było przedmiotem zbytku, dziś już mogło się stać przedmiotem powszechnego użytku, a nawet pierwszoplanową potrzebą. Wśród zalet podatków konsumpcyjnych wymienia się ich wydajność, elastyczność, taniość, dogodność dla zobowiązanego ponoszącego ciężar akcyzy, zapobieganie unikaniu opodatkowania czy wreszcie rozkładanie sumy ogólnego obciążenia podatkowego na drobniejsze, mniej odczuwalne kwoty. W odczuciu społecznym luksus to kategoria dóbr lub usług, które wyróżniają się wysoką ceną, jakością oraz trudną dostępnością dla odbiorcy, na którą rzadko może sobie pozwolić, bądź drogi przedmiot ułatwiający lub uprzyjemniający życie. Biorąc pod uwagę aktualny poziom cen wyrobów objętych akcyzą, która ma charakter cenotwórczy, można stwierdzić, że z tego punktu widzenia jest to podatek od luksusu.
Globalization and Diversification of Interior Decoration Styles and Their Impact on Pakistani Handicrafts
Authors: Khan Romana Yasmin , Honggu Ren , Abbas Moazzam , Jinjao Zhang , Liu Yuchen , Xinran Yang , Fang Wang , Islam Misbah Ul
Published: August 2023

With the gradual advancement of globalization, cultural values and traditional decorative practices as well as people’s lifestyles have changed through digital awareness. This has seriously affected the interior decoration industry and brought challenges to the local handicraft industry. Pakistan’s traditional handicraft is famous in the world, but the flow of imported machine-made products in Pakistan has led to a decline of Pakistan’s handicraft industry. This research investigated which factors are involved in home decoration and to see if these factors are advantageous for the handicraft industry or not. The use of handicraft decoration objects varies among people when they design their houses. Thus, study conducted a survey, which found several factors that Pakistani people emphasize in relation to home decoration. Currently, these factors do not benefit the handicraft industry as people pursue a modern lifestyle and they consider handicraft objects without innovation and design outdated. Interior decoration is seen as a major aspect of traditional Pakistani life and culture, with distinct cultural characteristics. Inspired by the latest way of thinking, an interior design first exists as a concept and is then realized through careful planning. It is meant to evoke a specific mood through the strategic use of color, space, and style. In Pakistan, home accessories are generally and strongly influenced by the current fashion in the end market, with many changes brought about by consumers’ purchasing patterns, designers’ and decorators’ styles, and economic conditions. Keeping up with constantly changing trends is the main challenge faced by the traditional handicraft industry sector. In many cases, craftspeople are disconnected from the end market, which is a challenge for them to be able to profit from their work.
Life history notes on the Oriole Blackbird (Gymnomystax mexicanus) in Venezuela
Authors: Skutch Alexander F.
Published: August 2023

This article does not have an abstract.
Analysis of Automatic Hand Sanitizer Using PIC16F877A Microcontroller
Authors: Abdurrahman Mubarak , Badru Ismaheel Adewale , Habu Abubakar , Abubakar Abdulkadir , Danladi Esau
Published: August 2023

The research was conducted to analyze an automatic non contactless hand sanitizer dispensing machine. Many researches focus on manual dispensers which makes the hand sanitizer dispenser to be contaminated. The system consists of monitoring and alert features. The liquid level of hand sanitizer was monitored by using LED-RED while alerting the system to remind the owner to refill the hand sanitizer if the level been low. Other than that, PIR sensor was used to detect the presents of human in nearby and thereafter dispenses the hand sanitizer. An automatic hand sanitizer dispensing machine was developed using microcontroller as the main brain behind of the system operation. Hand sanitizer dispenser can be used in many public places and else. The system employed usage of an ultrasonic sensor, which senses the hand placed near it, and connected to electrically operated pump that pumps out the hand sanitizer liquid for its users. The IR Sensor is the photodiode used for sensing the human hand detection and it is used to control the motor pump from the liquid.
Laboratory Determination of Productivity of Bomu Oil Field (Oml 11 as Case Study) Using MEOR Process and Calcium Oxide Nanoparticles
Authors: Nmegbu Chukwuma Godwin. J. , A. Edet Emmanuel. , Nmegbu Chindah
Published: August 2023

The need for petroleum products in the world is increasing daily, this product can only be gotten from the refining of crude oil a naturally occurring mineral resource which is produced by degradation of organic materials. This crude is gotten from several wells drilled for the sole purpose of the production of this mineral resource but this wells are being shut-down and abandoned because of the decrease in the well’s productivity which causes losses to the operators and poor finances for the petroleum industry. Therefore, the need to increase the recovery of a well is been considered, these methods are called enhanced oil recovery method. These methods include Gas injection method, Steam Injection method, Chemical injection method (chemicals such as surfactants, polymers etc) Microbial method and the use of nanoparticles as additives to help increase the recovery process. The type of enhanced oil recovery used in this work is the microbial enhanced oil recovery, this method makes use of biosurfactants which can also be referred to as microbe surfactants. The biosurfactants are gotten from microorganism they act as surfactants which reduces the interfacial tension between the molecules of the substance and the interface, this biosurfactants can be used for many industrial purposes which includes bioremediation, oil recovery etc. Nanoparticles are also another aspect of the recent technology which can increase the recovery of our well providing more crude and finance for the petroleum industry. This work shows how biosurfactants and nanoparticles when used together can increase oil recovery. The ever-rising global demand for energy and the issue of large volumes of unrecovered oil after primary and secondary oil production operations are driving the development and/or advancement of enhanced oil recovery (EOR) techniques. Conventional EOR processes include thermal, immiscible and miscible gas injection, chemical, and microbial enhanced oil recovery
Promoting the Use of Alternative Fuels for Road Transport in Nigeria
Authors: Okafor Izuchukwu F. , Obi Ikechukwu A.
Published: August 2023

Road transportation has been the most popular means of transport in Nigeria and one of the major energy-consuming sectors in the country. This sector is entirely dependent on non-renewable and polluting petroleum-based fossil fuels (petrol and diesel), for powering of road vehicles. This work discusses possible alternatives fuels such as ethanol, biofuels, biodiesel, methanol, compressed natural gas etc. and measures for promoting the use of these fuels for road transportation in the country. These fuels do not only burn cleaner, but also produce lower emissions and could reduce the country’s over-dependence on its’ finite fossil fuel as well as minimizing environmental pollution.
Social Media Marketing Techniques: A Conceptual Review on Transparency and Nation Building in Nigeria
Authors: Chinasa Atuo Eucharia
Published: August 2023

Social media marketing techniques are effective tools in building communities and other climes. Social media marketing techniques have become vital tools for individuals, organizations, private and public sectors to communicate and interact with one another. It further helps various governments and organizations to operate an open system that embraces openness, participation, and collaboration with the citizens. Social media marketing techniques also offers opportunities for government to solve its challenges of increasing national transparency and as well as improve citizen’s engagement. The study is a theoretical study that attempts to examine social media marketing techniques as contribution to transparency and nation-building. This paper discusses the need for social media marketing techniques in enhancing transparency and nation-building in Nigeria. The paper further concludes that a social media marketing technique within the context of transparency and nation building is seen as a veritable tool for nation building and national development in Nigeria. We recommend that government should establish the use of social media platforms and in all public offices and institutions to create a social bonding between government, citizens, and employees to achieve peace and national security and hereby enhance nation building
Customer Care Considerations and Business Performance of Small and Medium Scale Enterprises in Rivers State
Authors: Enyinda Ifeoma E.
Published: August 2023

This study examined the relationship between customer care considerations and business performance of small and medium scale enterprises in Rivers State. The study adopted the descriptive survey research design where data were collected from managers and marketers of ten (10) small and medium scale enterprises in the manufacturing sector. A sample of 233 respondents was used for the study. The sample size was determined using the Taro Yamane’s formula. A structured questionnaire was used to elicit data from the respondents. The data collected were analyzed using percentage and frequency analysis, mean and standard deviation, while the hypotheses were tested using Spearman Rank Order Correlation Coefficient (rho). The SPSS 22.0 version was used to correlate the data on the study variables. The findings revealed that there is significant relationship between customer enquiry consideration and customer satisfaction. The study also found a significant relationship between customer enquiry consideration and customer patronage of SMEs. A significant relationship was found between customer enquiry consideration and customer retention by SMEs. The study also reported a significant relationship between customer support consideration and customer satisfaction. The study equally discovered a significant relationship between customer support consideration and customer patronage of SMEs. A significant relationship was found between customer support consideration and customer retention by SMEs. The study also found a significant relationship between customer complaint consideration and customer satisfaction. A significant relationship was found between customer complaint consideration and customer patronage of SMEs. The study also reported a significant relationship between customer complaint consideration and customer retention by SMEs. Finally it was revealed that organizational size significantly moderates the relationship between customer care consideration
Effects of rehabilitative exercise on quality of life in patients with fibromyalgia. Clinical trials review
Authors: Mendoza Rivas Leandro , Armenta Alcocer Ismael Lázaro
Published: August 2023

Introduction: Fibromyalgia is a chronic disease characterized by widespread pain, fatigue and sleep disorders. Although there is no cure, multidisciplinary treatment, including lifestyle changes, cognitive-behavioral therapy and medications, can help control symptoms and improve quality of life.
Methods: a systematic review of clinical studies investigating the effectiveness of exercise in patients with fibromyalgia was conducted during the period from 2017 to 2021. A total of 29 relevant scientific articles that met the established inclusion criteria and filters were identified and evaluated.
Results: studies have shown that various physical activity interventions can have a positive impact on symptoms and quality of life in fibromyalgia patients, although efficacy may vary by modality. Obesity may moderate the benefits of treatment, and it is suggested that staying active may be an effective strategy in the management of fibromyalgia.
Conclusions: the most effective interventions were low-intensity physical exercise programs, such as resistance and coordination training; muscle stretching exercises and resistance training; core strengthening exercises and stretching exercises; and Tai Chi.
Review of clinical trials on the effectiveness of cognitive rehabilitation in patients with traumatic brain injury
Authors: Mendoza Rivas Leandro , Martínez Cruz Laura
Published: August 2023

Introduction: Traumatic brain injury (TBI) can impact patients' cognitive functioning and quality of life. This study assesses the effectiveness of cognitive interventions in TBI patients and examines factors influencing their success, aiming to enhance care and customize treatments for optimal rehabilitation outcomes.
Methods: a systematic review of 31 scientific articles evaluating the effectiveness of cognitive rehabilitation in patients with traumatic brain injuries was conducted, following the PRISMA workflow. The studies covered the period from 2017 to 2021, and specific terms were used to search the PubMed and Scopus databases.
Results: the research on cognitive interventions in patients with traumatic brain injuries has involved various countries, with notable contributions from the United States, Norway, the United Kingdom, and Canada. Cognitive training has proven to be effective, showing significant improvements in symptoms and quality of life. Other therapies, such as transcranial direct stimulation and vocational rehabilitation, have also been investigated.
Conclusions: cognitive training has proven to be an effective technique in managing traumatic brain injuries, demonstrating significant improvements in composite cognitive measures and patients' quality of life. Some therapies, such as hyperbaric oxygen therapy, have shown promising results in treating symptoms such as post-traumatic stress, depression, and anxiety in patients with traumatic brain injuries.
Occupational Psychosocial Factors and Stress in the Medical Assistance Personnel
Authors: Torres Aura , Pérez-Galavís Ariel , Ron Misael , Mendoza Nellys
Published: August 2023

Objective: to determine the psychosocial labor factors and stress in the medical personnel of a Municipality located in the State of Aragua - Venezuela, during the years 2022 - 2023.
Methods: This field research, within the positivist paradigm, quantitative approach, observational design, descriptive level and cross-section, included the participation of 24 attending physicians who had introduced rest for mental health, during the months of January and June of the year 2022; therefore, the sample was census. The survey was used as a data collection technique and the Chilean version Suseso-Istas 21 was used as a questionnaire.
Results: the most unfavorable levels were obtained in the dimensions: (95,8 %) psychological demands, Compensation (75,0 %), Social support and leadership quality (70,8 %) and Double presence (66,6 %). According to the Karasek, Johnson and Hall model, it was established that the type of work they do is high voltage.
Conclusion: medical care personnel are exposed to psychosocial risk factors that may be causing chronic diseases. Therefore, it is recommended to apply strategies aimed at minimizing the psychosocial risk to which they are exposed.
Tumor marker analysis in patients with gastrointestinal stromal tumors GIST
Authors: Chicaiza Jacome Karol Mayte , Proaño Pérez Elizabeth
Published: August 2023

Introduction: GISTs are sarcomas arising from interstitial cells of Cajal that account for about 1 % of all gastrointestinal tumors. The diagnosis of GIST involves imaging tests and invasive determinations such as endoscopy and biopsy. KIT and PDGFRA immunohistochemistry staining can detect 95 % of GISTs in biopsy samples. MicroRNAs (miRNAs) play a crucial role in angiogenesis physiology, immunology, and neural origins of GIST biology, and may be able to provide a valuable prognostic clue. Objective: this research aims to establish tumor markers (miRNAs) for the early diagnosis of GIST patients. Methods: a qualitative approach was used, of a bibliographic-documentary type, and through consultation in various databases found in indexed scientific journals. Results: miR-221, miR-222 play a functional, diagnostic, therapeutic, and prognostic role in GIST. The miR221/222 ratio is considered a genetic biomarker to detect the risk of developing GIST and hsa-miR-218-5p was the best predictor in the development of GIST as well as hsa-miR-146a-5p, hsa-miR- 222-3p, hsa-miR-126-3p and hsamiR-218-5p. Conclusions: new non-invasive diagnostic techniques for GIST could become a valuable strategy for early diagnosis and monitoring of patient treatment
The role of progressive brittle fracture in the 1931 landslide at Dogface Rock, Katoomba
Authors:   Jacobs Group (Australia) Pty Ltd, Tuckey Zack
Published: August 2023

The 1931 Dogface Rock landslide in Katoomba NSW was a complex, progressive cliff collapse with a failure volume in the order of 100,000 m3 that was triggered by the extraction of remnant coal pillars from the Katoomba Colliery, about 200 m below the top of the escarpment. Although underground coal mining is generally accepted as a cause of the rockslide, previous studies have not explicitly investigated the role of progressive brittle fracture in the collapse. This paper presents an integrated study which incorporates remotely piloted aircraft photogrammetry with a discrete element method numerical investigation of the landslide, and thereby explores the role of progressive brittle fracture, and re-examines the failure mechanism and runout motion of this multi-stage landslide. Remotely piloted aircraft photography is used to build a georeferenced 3D model of the site with Structure-from-Motion photogrammetry software. A digital geotechnical mapping workflow is demonstrated to investigate the morphology of the landslide scar, extract statistics on discontinuity orientation, persistence, and spacing, and undertake trace mapping of newer brittle fractures that interacted with pre-existing high persistence joints as the landslide rupture surface developed. A series of discrete element method numerical laboratory tests are used to calibrate bonded block contact properties that reproduce laboratory scale intact rock index parameters including UCS and tensile strength. Upscaled rock block contact parameters are then applied to a cliff-scale model that investigates the progressive development of rock mass damage induced by mining. Following extraction of the remnant pillars, rock mass damage develops mostly by extensile strains that produce tension cracks. Brittle fractures propagate upwards from the mine level and eventually initiate toppling of massive sandstone slabs defined by high persistence pre-existing subvertical joints. The investigation illustrates how the integration of photogrammetry with discrete element numerical methods can be used to characterise progressive brittle failure and runout of large rock slope failures.
Reproducibility of Somatic Embryogenesis Upon Resampling of Oil Palm Ortets
Authors:   United Plantations Bhd, LIM CHIN-CHING , WONG FOO-HIN , OOI SIEW-ENG ,   Malaysian Palm Oil Board
Published: August 2023

Somatic embryogenesis remains to be a key bottleneck in oil palm clonal propagation and resampling of embryogenic ortets may be one approach to alleviate this problem. Resampling, is currently practised by oil palm tissue culture laboratories to increase the production of clones from elite ortets. However, reproducibility of the embryogenesis outcome from resampling exercises has not been examined in detail. Therefore, embryogenesis reproducibility upon resampling was evaluated using the concordance correlation coefficient analysis. Sampling and resampling were conducted when ortets were seven to 19 years old. Resampling interval periods of three to eight years showed moderate concordance in embryogenesis reproducibility. An alternative analysis approach through categorising the ortets based on their embryogenesis outcomes into zero, low, medium and high embryogenesis categories indicated that 54.4 per cent of ortets reproduced their embryogenesis outcome while 35.6 per cent showed a shift by one embryogenesis category upon resampling. A resampling interval of 10 years was associated with a decline in embryogenesis outcomes. Observations from this study may help tissue culture laboratories in refining the selection of ortets for clonal propagation with the possibility of improving success rates in resampling exercises and thereby reducing operational costs. Keywords: Ortet, concordance, non-embryogenic, sampling interval.
Stratejik Yönetim Sürecinin Rekabet Gücü Üzerindeki Etkisinin İncelenmesi
Authors: YILDIRIM ÖZMUTLU Saniye
Published: August 2023

Stratejik yönetim, işletmenin amaç ve hedeflerine ulaşmasını sağlayan ve bir işletmenin tüm süreçlerine yön veren bir işletme yönetimi sürecidir. Bu çalışmanın amacı, stratejik yönetim sürecinin işletmelerin rekabet gücü üzerindeki etkisinin araştırılmasıdır. Araştırma evrenini Tekirdağ ili Çerkezköy ilçesi Organize Sanayi Bölgesinde faaliyetlerine devam eden 293 işletme oluşturmaktadır. Bu işletmelerde üst düzey yönetici statüsünde çalışan kişilere anket uygulanarak, anket yöntemiyle veriler toplanmıştır. Toplanan veriler yapısal eşitlik modeli yöntemi kullanılarak analiz edilmiştir. Elde edilen sonuçlar, stratejik yönetim sürecinin rekabet gücü üzerinde pozitif bir etkiye sahip olduğunu göstermektedir. Bununla birlikte stratejik yönetim sürecinin aşamalarının kolektif bir şekilde yönetilmesinin gerekliliğine değinilerek planlama esnekliği ve planlama vizyonu aşamalarının güçlendirilmesinin rekabet gücünü arttıracağı belirlenmiştir.
Ações e práticas do Fórum de Inovação Docente: relato de experiência
Authors: Gatti Regueiro Eloisa Maria , Ferreira Marlene de Cássia Trivellato , Pereira Milena da Silveira , Costa Patricia Maria Barbosa Jorge Sparvoli , Lima Priscila de Freitas , Papa Patricia Rodrigues Miziara , Paracchini Valéria Tomás de Aquino
Published: August 2023

O Fórum de Inovação Docente do Centro Universitário Barão de Mauá (CBM) teve sua primeira edição em 2018, pautada, entre outros aspectos, na inovação e aprendizagem; visando, de acordo com Papa e Paracchini (2022, p. 4), “proporcionar o que se chama ‘comunidade de prática’, em que se cria um momento de trocas das práticas dos envolvidos a fim de gerar novos conhecimentos”.
A propolisz különböző kivonatainak in vivo hatékonysága brojlercsirke szalmonellózisa esetén
Authors: Olasz Ákos , Jerzsele Ákos , Balta László , Dobra Péter Ferenc , Kerek Ádám
Published: August 2023

A terjedő antimikrobiális rezisztencia következtében egyre nagyobb hangsúlyt kap az antibiotikumalternatívák fejlesztése és alkalmazása. Ilyen pl. a propolisz, amely a méhek által készített természetes bakteriosztatikus vagy baktericid hatásmódú anyag. Vizsgálatukban a szerzők a propolisz brojlercsirkék szalmonellózisának megelőzésében és kezelésében betöltött lehetséges szerepét vizsgálták. Kimutatták, hogy a propolisz szignifikánsan nem befolyásolja a testtömeg-gyarapodást, ill. a fajlagos takarmányértékesítést a kontrollhoz képest, de csökkenti a szalmonellózis megeredésének esélyét. Kijelenthető, hogy a propolisz biztonságosan alkalmazható takarmánykiegészítő brojlercsirkék számára.
Kutya bélrendszeri megbetegedéseinek in vitro modellezési lehetőségei : Irodalmi összefoglaló
Authors: Móritz Alma Virág , Jerzsele Ákos , Psáder Roland , Farkas Orsolya
Published: August 2023

A gyomor-bélrendszer jelentős felülettel érintkezik a szájon át a szervezetbe jutó káros ágensekkel, és összetett funkciója révén jelentős szerepet játszik a kórokozó mikroorganizmusok távoltartásában. A gyulladásos bélbetegségek kutatása és terápiás lehetőségeinek vizsgálata tekintetében elengedhetetlen az in vitro modellek alkalmazása. A szerzők irodalmi összefoglalójukban bemutatják kutyák bélbetegségeinek tanulmányozására kifejlesztett in vitro modelleket. A homogén, kétdimenziós, fenntartható daganatos eredetű sejtvonalak mellett megjelentek olyan heterogén sejtösszetételű háromdimenziós organoidtenyészetek is, amikkel az in vivo körülmények jobban modellezhetővé váltak.
Cardiovascular Manifestations and Therapy Options for Systemic Lupus Erythematosus: A Systemic Literature Review
Authors: Hiba Nashat  , Sally Ghali  , Shadin Afif  , Vineet Suryadevara  , Yaman Habab  , Alana Hutcheson  , Binay Kumar Panjiyar  , Gershon Davydov  , Noor Abdulla  , Ann Kashmer Yu
Published: August 2023

Systemic lupus erythematosus (SLE) is an autoimmunemulti-systemic disease; it is a controlled disease but isnot curable. SLE affects different systems in the body,such as cardiac, renal, respiratory, hematology,neurology, and rheumatology. It can cause variousproblems in the heart, lungs, and joints. This Systemicreview researched articles from 3 databases: PubMed,Google Scholar, and PubMed Central in June 2022. Wedid this systemic review using Prisma guidelines. Wecollected this systemic review in the last five years. Freefull articles randomized controlled trial (RCT), systemicreview articles, and English language included. Otherlanguages and articles earlier than 2017. Joanna BriggsInstitute (JBI) checklist, Assessment of MultipleSystemic Reviews 2 (AMSTAR), and Scale for theAssessment of Multiple Systemic Reviews 2 (SANRA)are used to check for quality assessment. In thesystemic review, the initial search generated 516articles. They included 13 in the final selection; six werecase reports, two were systemic reviews, three of themretrospective studies, and two were literature reviews.In this Systemic review, we will focus on the cardiacmanifestations associated with systemic lupuserythematosus and use Hydroxychloroquine to preventthe deterioration of systemic lupus erythematosus anddecrease the incidence rate cardiac problems. Itdiscovered a decrease in the incidence rate of cardiacmanifestations. It found that hydroxychloroquine iseffective in the treatment of systemic lupuserythematosus patients. Not only that, but they foundthat Hydroxychloroquine effectively treats systemiclupus erythematosus patients and limits cardiac riskfactors. We need further studies and research tounderstand the effect of systemic lupus erythematosuson the cardiac system and the effects ofHydroxychloroquine on decreasing the impact ofsystemic lupus erythematosus on the heart.
Przeciw sowietom. Korpus Czechosłowacki na Syberii i jego wystąpienia przeciwko bolszewikom wiosną 1918 r.
Authors: Wiśniewski Jan
Published: August 2023

Korpus Czechosłowacki – formacja wojskowa utworzona w Rosji w czasie I wojny światowej z jeńców oraz dezerterów narodowości czeskiej i słowackiej z Cesarsko-Królewskiej Armii Austro-Węgierskiej oraz – w mniejszym stopniu – z Czechów i Słowaków mieszkających przed I wojną światową w Rosji, była formacją która odegrała bardzo dużą rolę w wznieceniu działań zbrojnych przeciwko bolszewikom na olbrzymich obszarach wschodniej Rosji, Uralu i Syberii oraz rosyjskiego Dalekiego Wschodu. Tradycje Korpusu Czechosłowackiego sięgały lata 1914 r., kiedy powstała jednostka pod nazwą „Czeska Drużyna” (Česká družina). W 1916 r. sformowano zaś Brygadę Czechosłowacką, a jesienią 1917 r. powstał już czterdziestotysięczny korpus w składzie dwóch dywizji piechoty. Po podpisaniu pokoju w Brześciu Litewskim w marcu 1918 r. Sowieci zgodzili się na ewakuację Korpusu Czechosłowackiego przez Władywostok do Francji. Jednak wskutek prób jego rozbrojenia w maju 1918 r. Korpus wystąpił przeciwko sowietom. Od maja do września 1918 r., wraz z tworzącymi się oddziałami „białogwardyjskimi”, Korpus Czechosłowacki opanował obszar od Wołgi po Ocean Spokojny. Umożliwiło to powstanie wschodniego ośrodka władzy „białych”Rosjan, kierowanego w późniejszym czasie przez adm. Aleksandra Kołczaka. Po stratach zadanych Korpusowi Czechosłowackiemu przez Robotniczo-Chłopską Armię Czerwoną został zreorganizowany i skierowany do osłony Kolei Transsyberyjskiej. Podczas ewakuacji z Syberii walczył z siłami sowieckimi. W wyniku porozumienia z Kujtun zawartego 7 lutego 1920 r. dowództwo czechosłowackie wydało w ręce Sowietów adm. Aleksandra Kołczaka, który wcześniej oddał się pod opiekę Korpusu oraz tzw. „złoty skarb Rosji”. W zamian wojska czechosłowackie mogły swobodnie ewakuować się do Władywostoku. Do końca 1920 r. czechosłowaccy legioniści opuścili tereny dalekowschodniej Rosji drogą morską i dalej przez Europę Zachodnią dotarli do Czechosłowacji.
Na zapleczu frontów Armii Czerwonej. Sowieckie zbrodnie, represje i grabieże na ziemiach polskich w 1945 r. (na przykładzie wybranych miast)
Authors: Golon Mirosław
Published: August 2023

Działania władz sowieckich na ziemiach polskich w 1945 r. przez kilkadziesiąt lat po wojnie były obiektem bardzo intensywnych działań propagandy komunistycznej. Celem było wykazanie głównie aspektu „wyzwolenia” przez Armię Czerwoną i tak jest także dziś, po prawie 80 latach w Federacji Rosyjskiej. Elementem tej propagandy była wielka akcja budowy komunistycznych obiektów, nazywanych pomnikami wdzięczności, które w większości zostały już w Polsce zdemontowane. Tymczasem rzeczywistość 1945 r. była dramatycznie odmienna od jakiegokolwiek wyzwolenia. Jedna okupacja została zastąpiona przez inną. Z politycznej perspektywy najistotniejsze było zniszczenie bezpośrednio przez władze sowieckie znacznej części struktur Polskiego Państwa Podziemnego, w tym najważniejszej jego części czyli Armii Krajowej. To w kierownictwo i kadrę polskiej konspiracji niepodległościowej uderzyły masowe represje z mordami i więzieniami, często w głębi Związku Sowieckiego. Poza tymi politycznie uwarunkowanymi represjami, ogromna część polskiej ludności cywilnej padła ofiarą różnorodnych szykan, rabunków, gwałtów, a niejednokrotnie zbrodni o kryminalnym charakterze, które na niespotykaną w dziejach wojen skalę popełniali żołnierze wielomilionowej Armii Czerwonej przemieszczającej się przez polskie ziemie.Sowieckie władze wojskowe, policyjne i administracyjne, odegrały też ogromną rolę w powiększeniu i tak już nieprawdopodobnie wielkiej skali strat ekonomicznych Polski. Eksploatacja ziem polskich wiązała się nie tylko z masowym, rabunkowym wykorzystywaniem zasobów zajmowanych ziem dla wzmacniania potencjału walczącej armii, dla jej doposażenia, wyżywienia itd. Większość rabunków kierowano na wschód, dla wzmocnienia państwa Stalina. Spowodowało to bardzo duże pogłębienie i tak już znaczącego zubożenia ziem polskich w okresie II wojny światowej, a także zmniejszenie potencjału ekonomicznego ziem nowych, poniemieckich, które Polska zajęła w 1945 r. Na wybranych przykładach kilku ośrodków, m.in. Włocławka, Torunia i Grudziądza przedstawiono też szczegółowe uwagi dotyczącej eksploatacji polskich zasobów ekonomicznych przez sowieckie władze w 1945 r.
Działania polskiej Policji na rzecz budowania kultury
Authors: Amrozy Katarzyna
Published: August 2023

W artykule omówiono teoretyczny i praktyczny wymiar kultury organizacyjnej służb mundurowych, na przykładzie polskiej Policji. Skupiono się na opisaniu roli, funkcji tejże kultury, przytoczono także pozytywne i negatywne aspekty tego zjawiska. Druga część została poświęcona przykładom konkretnych działań. Można tu wymienić: imprezy sportowe, charytatywne, pikniki, festyny, konkursy, akcje krwiodawstwa, pokazy kynologiczne, spotkania z dziećmi, studentami oraz innymi grupami, organizację konferencji, wystaw, nagrywanie podcastów, filmików, tik toków, wydawanie policyjnych czasopism, ceremoniał policyjny, pracę w ramach stowarzyszeń i fundacji, politykę informacyjną, twórczość literacką, programy telewizyjne, nieoficjalne działania funkcjonariuszy po służbie.
Integrated writing pedagogy in the EFL classroom
Authors: Jednaszewski Piotr
Published: August 2023

The following article discusses something which is frequently perceived as nothing more than homework by many instructors of English as a Foreign Language (EFL) for its time-consuming nature: second language writing. The first section outlines some issues that students of English often experience when taking English-language classes. Here, references to specific cultures are made, but the problems can also be universally considered. The subsequent section describes two specific approaches to writing instructors can adopt in their own classrooms and evaluates their effectiveness. The third and final section details how instructors may go about borrowing aspects of the two approaches to form an integrated approach aimed at helping students to overcome the problems they face in composing L2 texts. Here, procedural outlines are included so that instructors can take this integrated writing pedagogy into their own EFL classrooms.
Foliar Spectral Signature Analysis of Three Pepper (Piper nigrum L.) Cultivars in Malaysia
Authors: Kevin Muyang Tawie Anak Sulok  , Angela Tida Henry Ganie  , Kho Pei Ee  , Wong Chin Mee  , Chen Yi Shang  , Zehnder Jarroop Augustine Mercer  , Ahmed Osumanu Haruna  , Affendi Suhaili
Published: August 2023

Pepper (Piper nigrum L.) is an important cash crop for smallholders in the state of Sarawak, Malaysia. At present, there are more than eight pepper cultivars being planted in the state since the 1950s. In this study, the unique spectral signatures of three high yielding pepper cultivars in Malaysia were examined using a ground-based spectral sensor to detect varietal differences. Concurrent foliar spectral signatures, chlorophyll concentration, and Normalized Difference Vegetation Index (NDVI) of cultivar Kuching, Semongok Aman and Semongok Emas were recorded under normal field conditions. Foliar chlorophyll concentration and NDVI results showed that all the matured pepper vines under this assessment were in healthy condition. From a rough observation, except for a slight increase in the visible (VIS) region of the spectrum (500 to 699 nm) for cultivar Semongok Aman and Semongok Emas, spectral reflectance of all three pepper cultivars were similar in the near-infrared region (700 to 1000 nm). The results for First Derivative Curves analysis indicated that the 684.5 to 756.5 nm region showed the highest separation followed by region with the second lowest separation (504.5 to 540.5 nm). The highest value was obtained in the Red Edge Position (REP) for cultivar Kuching, Semongok Aman and Semongok Emas which were 709, 706 and 710, respectively. The highest value obtained in the VIS region for cultivar Kuching, Semongok Aman and Semongok Emas were 523, 524 and 527, respectively. These fundamental findings suggested that it is possible to discriminate pepper cultivars through field spectroscopy and first derivative analysis. In addition, this information may be used for further studies related to precision agriculture particularly in integrated nutrient and disease management.
PiCUS Sonic Tomograph: A Case Study of Crimson Bottlebrush Tree (Melaleuca citrina (Curtis) Dum.Cours)
Authors: Abdul Hayat Mat Saad  , Ahmad Nazarudin Mohd Roseli  , Rosfarizal Kamaruzaman
Published: August 2023

Trees with a decreasing level of health and structure can become a threat to life and property if they are not properly managed. Thus, a regular visual tree assessment (VTA) is essential to monitor the trees’ conditions. A recent assessment, July 2022, by VTA on an existing Melaleuca citrina in the Forest Research Institute Malaysia (FRIM) showed poor canopy growth colonised by parasitic plants with the emergence of fruiting bodies (conk or mushroom) on its trunk, indicating internal wood decay. Tree inspection using an advanced approach of PiCUS Sonic Tomograph (PiCUS) was performed to evaluate the severity of the decayed trunk. As a non-invasive method, PiCUS measures the wood deterioration in trees using sound wave velocity that moves through the density of the wood. The thicknesses of the residual wall of trees with internal defects were recorded as colour-coded tomograms. The results were then compared with previous observations in the year 2017. The soil penetration test, pH and “The Jar Test” were also adopted to analyse soil properties and condition around the tree. The tomogram images showed an increased percentage of decay from 2017 to 2022 of approximately 2 to 78%, respectively. The sound wood also decreased from 82 to 14% for the respective period. The soil is categorised as silt loamy with pH value of 5.6 to 6.4 while the soil penetration test exceeds a value of 2.06 MPa, which restricts the root growth. This information is vital for further maintenance of urban trees and very useful for managerial decisions.
NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency
Authors: Lee Mingyun , Oh Jong-Nam , Choe Gyung Cheol , Choi Kwang-Hwan , Lee Dong-Kyung , Kim Seung-Hun , Jeong Jinsol , Ahn Yelim , Lee Chang-Kyu
Published: August 2023

Objective: Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2). It is an epiblast lineage marker in mammalian pre-implantation embryos and exhibits a species-specific expression pattern. Therefore, it is important to understand the lineage of NANOG, the trophectoderm, and the primitive endoderm in the pig embryo.Methods: A loss- and gain-of-function analysis was done to determine the role of NANOG in lineage specification in parthenogenetic porcine blastocysts. We analyzed the relationship between NANOG and pluripotent core transcription factors and other lineage makers.Results: In NANOG-null late blastocysts, OCT4-, SOX2-, and SOX17-positive cells were decreased, whereas GATA binding protein 6 (GATA6)-positive cells were increased. Quantitative real-time polymerase chain reaction revealed that the expression of SOX2 was decreased in NANOG-null blastocysts, whereas that of primitive endoderm makers, except SOX17, was increased. In NANOG-overexpressing blastocysts, caudal type homeobox 2 (CDX2-), SOX17-, and GATA6-positive cells were decreased. The results indicated that the expression of primitive endoderm markers and trophectoderm-related genes was decreased.Conclusion: Taken together, the results demonstrate that NANOG is involved in the epiblast and primitive endoderm differentiation and is essential for maintaining pluripotency within the epiblast.
The Effects of Vitamin D3 Supplementation and Simultaneous Exercise on Aldehyde Dehydrogenase Gene Expression in Endometriosis Female Rats
Authors: Nameni Farah , Ebrahimmosavi Mahssadat
Published: August 2023

Background: Endometriosis is an injury caused by the proliferation of endometrial tissue outside the uterine cavity. Exercise and supplements may effectively remove waste materials and produce antioxidant enzymes. Objectives: The present research aimed to investigate the effects of simultaneous exercise and vitamin D3 supplement on aldehyde dehydrogenase 2 (ALDH2A1) gene expression in endometriosis female rats. Methods: The experimental method with a post-test design was used to conduct the research. The statistical population of the study consisted of three-month-old female Wistar rats. After the induction of the endometriosis model, the rats were divided into six groups. The exercise groups performed simultaneous exercises for eight weeks. Vitamin D3 supplement at 50 mg was fed to rats daily for eight weeks. The mean and standard deviation of ALDH2A values were calculated, and two-way analysis of variance (ANOVA) and Bonferroni post hoc test were investigated in female rats in different groups (P