bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of intraepidermal nerve fiber density and neurophysiological studies in patients with idiopathic polyneuropathy
Authors: Metwally Nabiel Abd Elhakeem , Hasan Mahmoud Mohamad , Abd Elaziz Abd Elaziz Shokry , Elhadad Ali Farrag , Ibraheem Kamal Shabaan , Ali Mohammed Ahmed Ahmed , Elsalam Hesham Atif Abd
Published: December 2022

Background

Idiopathic polyneuropathy is an asymmetrical, length-dependent neuropathy in which neurophysiology demonstrates axonal damage involving large fibers, along with insidious onset and slow progression over 6 months, with no identified etiology in spite of thorough investigations. This study aimed to evaluate the diagnostic role of clinical, electrophysiological, and histopathological studies in patients with idiopathic polyneuropathy.

Methods

Case–control study included 20 patients with clinical and neurophysiological evidence of sensory or sensory–motor neuropathy with no apparent etiology after laboratory investigation were recruited from 127 patients with sensory–motor neuropathy of unknown etiology (the patients group). Twenty apparently healthy individuals, age- and sex-matched, with no neuropathy symptoms (the control group), were recruited from the Neurology Clinic of Al-Azhar University, Assuit.

Results

Age of onset of patients with idiopathic polyneuropathy (44–70) years, duration of illness (1–6) years, 60% had painful neuropathy, diagnostic neuropathic pain questioner (DN4 score) (5–7), abnormal pin brick (80%), abnormal vibration (90%), abnormal fine touch (75%), distal weakness (70%), and lost ankle reflex (90%). In the control group, there were substantial differences with respect to prolonged latency, diminished sympathetic skin response amplitude, and significant intraepidermal nerve fiber density reduction in skin biopsy cases. In diagnosing idiopathic polyneuropathy, the specificity and sensitivity of sympathetic skin response were (80–86)% and (81–89.5)%, respectively, whereas those of diminished intraepidermal nerve fiber density were (92.5%) and (97.5%), respectively.

Conclusion

The assessment of intraepidermal nerve fiber density had an important good diagnostic role in cases presented with polyneuropathy.
Postconditioning with lactate-enriched blood in ST-segment elevation myocardial infarction
Authors: Koyama Takashi , Akima Takashi
Published: December 2022

Background

Ischemic postconditioning failed to demonstrate improved outcomes in patients with ST-segment elevation myocardial infarction (STEMI) in large-scale studies. We examined the cardioprotective effects of a modified postconditioning protocol, which was named postconditioning with lactate-enriched blood (PCLeB).

Methods

This study included 100 consecutive patients with STEMI treated in the Saitama Municipal Hospital within 12 h of symptom onset since March 2014 to July 2020 with one-year follow-up. PCLeB was implemented at the beginning of reperfusion. PCLeB comprised intermittent reperfusion and timely coronary injections of lactated Ringer’s solution, aimed at achieving controlled reperfusion with myocardial oxygenation and minimal washout of lactate to prolong tissue acidosis in comparison with the original protocol. Outcome measures were in-hospital and one-year mortality and re-hospitalization rates for heart failure within one year.

Results

In-hospital and one-year mortality were zero and none was re-hospitalized for heart failure during the one-year follow-up period among the 100 study patients.

Conclusions

PCLeB was associated with zero mortality and no re-hospitalization for heart failure at one year among 100 consecutive patients with STEMI who underwent reperfusion therapy.
CD19+CD24highCD27+ B cell and interleukin 35 as potential biomarkers of disease activity in systemic lupus erythematosus patients
Authors: Xiong Hui , Tang Zengqi , Xu Ying , Shi Zhenrui , Guo Zhixuan , Liu Xiuting , Tan Guozhen , Ai Xuechen , Guo Qing
Published: December 2022

Background

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that associates with aberrant activation of B lymphocytes and excessive autoantibodies. Interleukin 10 (IL-10)/interleukin 35 (IL-35) and IL-10/IL-35-producing regulatory B cells have been demonstrated to possess immunosuppressive functions during systemic lupus erythematosus. Here, we detected the proportion of CD19+CD24highCD27+ B cells as well as IL-10 and IL-35 levels in peripheral blood of SLE patients and healthy individuals, and investigated their relations with clinical features of SLE.

Methods

41 SLE patients and 25 healthy controls were recruited. The patients were divided into groups based on SLEDAI score, anti-dsDNA antibody, rash, nephritis and hematological disorder. Flow cytometry was used to detect the proportion of CD24hiCD27+ B cells. ELISA was used to detect serum levels of IL-10 and IL-35.

Results

Our results showed that the CD19+CD24highCD27+ B population was decreased in active SLE patients, and anti-correlated with the disease activity. Of note, we found significant increase of IL-10 and decrease of IL-35 in SLE patients with disease activity score > 4, lupus nephritis or hematological disorders compared to those without related clinical features.

Conclusions

Reduced CD19+CD24highCD27+ B cells expression may be involved in the pathogenesis of SLE. Moreover, we supposed that IL-35 instead of IL-10 played a crucial role in immune regulation during SLE disease.
Longitudinal analysis of the faecal microbiome in pigs fed Cyberlindnera jadinii yeast as a protein source during the weanling period followed by a rapeseed- and faba bean-based grower-finisher diet
Authors: Iakhno Stanislav , Delogu Francesco , Umu Özgün C. O. , Kjos Nils P. , Håkenåsen Ingrid M. , Mydland Liv T. , Øverland Margareth , Sørum Henning
Published: December 2022

The porcine gut microbiome is central to animal health and growth as well as it can be structurally or functionally reshaped by dietary interventions. The gut microbiota composition in relation to Cyberlindnera jadinii yeast as a protein source in a weanling diet was studied previously. Also, there is a mounting body of knowledge regarding the porcine gut microbiome composition in response to the use of rapeseed (Brassica napus subsp. napus) meal, and faba beans (Vicia faba) as protein sources during the growing/finishing period. However, there is limited data on how the porcine gut microbiome respond to a combination of C. jadinii yeast in the weanling phase and rapeseed meal and faba beans in the growing/finishing phase. This work investigated how the porcine faecal microbiome was changing in response to a novel yeast diet with a high inclusion of yeast proteins (40% of crude protein) in a weanling diet followed by a diet based on rapeseed meal and faba beans during the growing/finishing period. The faecal microbiomes of the weanling pigs fed yeast were more diverse with higher relative abundance of Firmicutes over Bacteroidetes compared with those of soybean meal-based diet fed weanlings. Reduced numbers of Prevotella in the yeast fed faecal microbiomes remained a microbiome characteristic up until two weeks after the yeast diet was changed to the rapeseed/faba bean growing finishing diet. A number of differentially abundant bacterial phylotypes along with distinct co-occurrence patterns observed during the growing/finishing period indicated the presence of a “carry-over” effect of the yeast weanling diet onto the faecal microbiomes of the grower/finisher pigs.
Quantifying implementation strategy and dissemination channel preferences and experiences for pain management in primary care: a novel implementer-reported outcome
Authors: Ashcraft Laura Ellen , Moon Deborah J. , Merlin Jessica S. , Eack Shaun M. , Rogal Shari S.
Published: December 2022

Background

Precision implementation science requires methods to evaluate and select implementation strategies. This study developed and evaluated a novel measure of concordance between current and preferred dissemination channels (DC) and implementation strategies (IS) to guide efforts to improve the adoption of evidence-based management strategies for chronic pain.

Methods

We conducted a one-time electronic survey of Pennsylvania primary care practitioners (PCPs) about current vs. preferred chronic pain management DC and IS use. Survey items were selected based on preliminary data, the Model for Dissemination of Research, and the Evidence-Based Recommendations for Implementing Change taxonomy of implementation strategies. We used Cohen’s kappa (κ) to assess the agreement between participant-level current and preferred DC/IS. We calculated % preferred minus % experienced for each DC/IS and assessed the equality of proportions to determine whether this difference significantly departed from zero. We categorized DC and IS based on the degree of use and preference, to evaluate alignment.

Results

The current sample included 101 Pennsylvania PCPs primarily in urban (94.06%), non-academic (90.10%) settings who self-identified as mostly female (66.34%) and white (85.15%). The greatest difference between preferred and experienced DCs, or “need,” was identified by participants as workshops, clinical experts, seminars, and researchers. Similarly, participants reported the greatest IS gaps as multidisciplinary chronic pain workgroups, targeted support for clinicians, and a chronic pain clinical champion. Participating PCPs had moderate DC concordance (kappa = 0.45, 95% CI = 0.38–0.52) and low IS concordance (kappa = 0.18, 95% CI = 0.13–0.23). DC and IS concordance were both greater than that expected by chance. We further identified well-aligned DC and IS, including professional organizations, briefs, and guidelines.

Conclusion

We identified a novel implementer-reported outcome of dissemination channel and implementation strategy concordance that allows implementation scientists to quantify the magnitude of the gap between the current and preferred experience of implementers. This quantitative measure can help with the selection and evaluation of dissemination channels and implementation strategies. Future research should leverage this measure to understand the degree to which preference concordance influences clinical outcomes and performance.
Support vector regression-bald eagle search optimizer-based hybrid approach for short-term wind power forecasting
Authors: Amroune Mohammed
Published: December 2022

Wind power forecasting deals with the prediction of the expected generation of wind farms in the next few minutes, hours, or days. The application of machine learning techniques in wind power forecasting has become of great interest due to their superior capability to perform regression, classification, and clustering. Support vector regression (SVR) is a powerful and suitable forecasting tool that has been successfully used for wind power forecasting. However, the performance of the SVR model is extremely dependent on the optimal selection of its hyper-parameters. In this paper, a novel forecast model based on hybrid SVR and bald eagle search (BES) is proposed for short-term wind power forecasting. In the proposed model, the BES algorithm, which is characterized by a few adjustable parameters, a simplified search mechanism, and accurate results, is used to enhance the accuracy of the forecasted output by optimizing the hyper-parameters of the SVR model. To evaluate the performance of the developed wind power forecaster, a case study has been conducted on real wind power data from Sotavento Galicia in Spain. The developed model is compared to other forecasting techniques such as decision tree (DT), random forest (RF), traditional SVR, hybrid SVR, and gray wolf optimization algorithm (SVR–GWO) and hybrid SVR and manta ray foraging optimizer (SVR–MRFO). Obtained results uncovered that the proposed hybrid SVR−BES is more accurate than other methods.
Exploring the Complementarity of Measures of Instructional Practices
Authors: Shi Lu , Popova Maia , Erdmann Robert M. , Pellegrini Anthony , Johnson Victoria , Le Binh , Popple Trina , Nelson Zachary , Gaston Molly Undersander , Stains Marilyne
Published: December 2022

Analysis of the complementarity of two measures of instructional practices—COPUS and LCTR—showcases the challenges in characterizing instructional quality.
Σχεδιασμός, σύνθεση και βιολογικός έλεγχος νέων αναλόγων του φαρμακευτικού σκευάσματος Lenvatinib ως εν δυνάμει αναστολέων του υποδοχέα του αγγειακού ενδοθηλιακού αυξητικού παράγοντα 2 (VEGFR2) και βελτιστοποίηση της συνθετικής του πορείας
Authors: Αλαγιάννης Μιχάλης
Published: December 2022

Η εκλεκτική αναστολή των πρωτεϊνικών κινασών, που επηρεάζουν κυτταρικές διεργασίες με την ενζυματική μεταφορά της τελικής φωσφορικής ομάδας του ΑΤΡ στο υδροξύλιο της πλευρικής αλυσίδας της σερίνης, της θρεονίνης ή της τυροσίνης μιας πρωτεΐνης, έχει καθιερωθεί ως μία από τις πλέον υποσχόμενες θεραπευτικές στρατηγικές για την αντιμετώπιση ασθενειών, όπως ο καρκίνος. Τυχόν μεταλλάξεις των μορίων των πρωτεϊνικών κινασών οδηγούν στην αυτόνομη και μη ελεγχόμενη συμπεριφορά των καρκινικών κυττάρων, διαταράσσοντας τους μηχανισμούς που ρυθμίζουν τη διαίρεση, την επιβίωση και την απόπτωση των κυττάρων. Η αναστολή των παθολογικών πρωτεϊνικών κινασών από μόρια μικρού μοριακού βάρους, που ανταγωνίζονται ως προς τη θέση πρόσδεσης το ΑΤΡ στο ενεργό κέντρο της κινάσης, έχει αποδειχθεί από μελέτες ότι συμβάλλει σημαντικά στην αντιμετώπιση και τη θεραπεία νεοπλασιών. Ακριβώς για το λόγο αυτό, υπάρχει μεγάλο ενδιαφέρον στην επιστημονική κοινότητα για την ανάπτυξη και παραγωγή νέων αναστολέων πρωτεϊνικών κινασών, οι οποίοι θα δρουν εκλεκτικά, αναστέλλοντας τη δράση μόνο της παθολογικής πρωτεϊνικής κινάσης.Tο Lenvatinib, ένα φαρμακευτικό σκεύασμα εγκεκριμένο από τον FDA μόλις το Μάιο του 2016, είναι ένας αναστρέψιμος εκλεκτικός αναστολέας του υποδοχέατου αγγειακού ενδοθηλιακού αυξητικού παράγoντα 2 (VEGFR2) και χορηγείται σε ασθενείς για τη θεραπεία του διαφοροποιημένου καρκίνου του θυρεοειδούς μετά από μη ανταπόκριση τους με ραδιενεργό ιώδιο. Επιπρόσθετα ο FDA ενέκρινε το Lenvatinib για τη θεραπεία του προχωρημένου νεφροκυτταρικού καρκινώματος, καθώς έχει καλύτερη ανασταλτική δράση από τα είδη υπάρχοντα φάρμακα Sorafenib και Sunitinib.Στο εργαστήριο, κατά την εκπόνηση της διδακτορικής διατριβής, επετεύχθη η σύνθεση αναλόγων/παραγώγων του Lenvatinib αντικαθιστώντας την δομή της ουρίας με εκείνη του αμιδικού δεσμού καθώς και του κυκλοπροπανίου με τις δομές του φουρανίου, θειοφαινίου, θειαζολίου και ενός φυσικού αμινοξέος, της Lπρολινης. Οι εν λόγω στοχευμένες τροποποιήσεις είναι αποτέλεσμα μοριακής μοντελοποίησης, έτσι ώστε οι νέοι εν δυνάμει αναστολείς να δρουν αποτελεσματικότερα κατά του υποδοχέα του αγγειακού ενδοθηλιακού αυξητικού παράγοντα 2 (VEGFR2) , με στόχο την εκλεκτική αναστολή αυτού. Επιπλέον, κατά την διάρκεια της διδακτορικής διατριβής έγινε προσπάθεια ανάπτυξης μιας βελτιστοποιημένηςολικής πορείας σύνθεσης του φαρμακευτικού σκευάσματος Lenvatinib. Τέλος, τα ανάλογα του Lenvatinib που συντέθηκαν στο εργαστήριο υποβλήθηκαν σε έναν πρώτο βιολογικό έλεγχο έναντι της καρκινικής σειράς MC-
Ανεύρεση των παραγόντων που προδιαθέτουν την πρόκληση αθλητικών κακώσεων σε αθλητές/τριες του θαλάσσιου σκι και του γουέικμπορντ (wakeboard)
Authors: Αραχωβίτης Αντώνιος
Published: December 2022

Ο σκοπός της παρούσας μελέτης ήταν η καταγραφή και ανάλυση των τραυματισμών που συμβαίνουν στους αθλητές/αθλήτριες του θαλασσίου σκι και γουέϊκμπορντ στην Ελλάδα. Η έρευνα διεξήχθη πανελλάδικα στο σύνολο των σωματείων που δραστηριοποιούνται στα συγκεκριμένα αθλήματα. Το δείγμα της έρευνας αποτέλεσαν 140 αθλητές του θαλασσίου σκι και γουέϊκμπορντ, εκ των οποίων οι 104 (74.3%) ήταν άνδρες και οι 36 (25.7%) ήταν γυναίκες. Εκ του συνόλου των συμμετεχόντων οι 92 (65.7%) ήταν αθλητές του θαλάσσιου σκι ενώ οι 48 (34.3%) ήταν αθλητές του γουέϊκμπορντ. Για τη συγκεκριμένη έρευνα κατασκευάστηκε μετά από ενδελεχή βιβλιογραφική ανασκόπηση ερωτηματολόγιο αυτοαναφοράς σχετικά με τους τραυματισμούς (Junge & Dvorak, 2004; Moreno-Alcaraz, Cejudo, & de Baranda, 2020; Park, Lee, & Kim, 2019; Piri, Alizadeh, & Nasiri, 2020; Willick, Cushman, Klatt, Brobeck, Spencer, & Teramoto, 2020). Η αποστολή των ερωτηματολογίων έγινε ηλεκτρονικά διαμέσου της Ομοσπονδίας προς τα σωματεία και στη συνέχεια στους αθλητές τους. Για τη στατιστική ανάλυση υλοποιήθηκε περιγραφική στατιστική με Μέσους Όρους και Τυπικές Αποκλίσεις και χ2 για την στατιστική σημαντικότητα των αποτελεσμάτων. Συνολικά αναφέρθηκαν 291 περιπτώσεις τραυματισμών. Η ανατομική περιοχή με την μεγαλύτερη εμφάνιση τραυματισμών ήταν η άρθρωση του γονάτου (16.5%), η ποδοκνημική άρθρωση (14.8%) και η ωμική ζώνη (11.7%). Οι θλάσεις αποτέλεσαν το (21.3%), τα διαστρέμματα (17.4%), οι μυικές ρήξεις (2ου και 3ου βαθμού) (17%) και τα κατάγματα (10%). Το αγώνισμα του σλάλομ παρουσίασε τους περισσότερους τραυματισμούς (44.8%), το αγώνισμα του άλματος (18,1%) και το αγώνισμα των φιγούρων (9.1%). Οι περισσότεροι τραυματισμοί σημειώθηκαν στην κατηγορία των Ανδρών-Γυναικών (Ν=82, 73.2%, χ2= .033, p= .855), και από το σύνολο των περιπτώσεων το 92,9% συνέβη κατά την διάρκεια της προπόνησης (χ2= .014, p= 1.000). Από τις 112 περιπτώσεις τραυματισμών που αναφέρθηκαν το 40.2% παρουσιάστηκε όταν οι αθλητές/ αθλήτριες είχαν εκτελέσει ένα ολοκληρωμένο πρόγραμμα διατατικών ασκήσεων, είχαν καλή ψυχική διάθεση (42.9%) ενώ το μεγαλύτερο ποσοστό των αθλητών δεν χρησιμοποιεί κάποιου είδους προστατευτική περίδεση (43.8%) . Ανάμεσα στα αθλήματα του θαλάσσιου σκι και γουειμπορντ η μεγαλύτερη συχνότητα τραυματισμών παρουσιάστηκε στο θαλάσσιο σκι (63.4%) και στο γουέϊκμπορντ (36.6%) (χ2= 1.737, p= .420). Η κατηγορία των Α/Γ (Ανδρών/Γυναικών) εμφάνισε τους περισσότερους τραυματισμούς (44.3%), η Α35 (Ανω 35) (42.1%) και οι Π-Κ/Ε-Ν (13.6%) (χ2= .836, p= .658). Οι περισσότεροι τραυματισμοί (81.3%) (χ2=1.663, p= .435), συνέβησαν σε χώρο όπου δεν υπήρχε εξειδικευμένο προσωπικό για παροχή Α΄Βοηθειών.
Η Υστερομινωική ΙΙΙ κατοίκηση στη βορειοανατολική Κρήτη κατά τη Μετανακτορική περίοδο
Authors: Ψύχας Αδριανός
Published: December 2022

Η παρούσα διδακτορική διατριβή πραγματεύεται τα αποτελέσματα της παράλληλης εξέτασης του μετανακτορικού υλικού (αρχιτεκτονική και κεραμεική) από τους Λόφους Ι και ΙΙ του Πετρά Σητείας. Η μελέτη της κεραμεικής και των αρχιτεκτονικών καταλοίπων έχει σκοπό να παρουσιάσει, αναλυτικά, την κατοίκηση στους δύο λόφους και να εντάξει τη θέση στο ευρύτερο ιστορικό πλαίσιο της Μετανακτορικής περιόδου στον κόλπο της Σητείας και της βορειοανατολικής Κρήτης, ευρύτερα. Σημαντικός άξονας της έρευνας αποτελεί η εξέλιξη των κεραμεικών σχημάτων και η κατανόηση των υλών τους, ώστε να επιτευχθεί, όσο το δυνατόν, η ανασύνθεση του κοινωνικού-οικονομικού ρόλου του Πετρά σε σχέση με το οικιστικό δίκτυο της ενδοχώρας της σύγχρονης Σητείας και με άλλες, σημαντικές, μετανακτορικές εγκαταστάσεις κατά μήκος του νησιού (π.χ. Παλαίκαστρο, Ζάκρος, Μόχλος, Γουρνιά, Κνωσός, Αγία Τριάδα, Χανιά κ.ά.). Παράλληλα, η συμμετοχή των κατοίκων του Πετρά στις τυπολογικές εξελίξεις της ΥΜ ΙΙΙ Κρήτης επιβεβαιώνεται και μέσα από την ανάλυση της αρχιτεκτονικής και των επιμέρους μορφολογικών χαρακτηριστικών κάθε κτιρίου, που βρίσκουν παράλληλα στις παραπάνω, αναφερθείσες, θέσεις. Ιδιαίτερα, έμφαση δίνεται στην κατανόηση της θεμελίωσης μετανακτορικών κοινοτικών κτιρίων επάνω από τα -εν μέρει, ορατά- ερείπια των τάφων, του πρωιμότερου ΠΜ Ι-ΜΜ ΙΒ νεκροταφείου, στον Λόφο ΙΙ, στην ανάλυση των κεραμεικών σχημάτων που βρέθηκαν σε αυτά τα κτίρια, και στην πιθανή ερμηνεία αυτής της επιλογής, τόσο αρχιτεκτονικά όσο και ιδεολογικά. Συμπερασματικά, η έρευνα επιτρέπει να αναγνωριστεί η ιστορία της εγκατάστασης στους Λόφους Ι και ΙΙ του Πετρά κατά την ΥΜ ΙΙΙΑ/Γ περίοδο, επιβεβαιώνει την κομβική γεωπολιτική του θέση και αναδεικνύει τον πολιτικο-οικονομικό, και τον ιστορικό, πιθανά, ρόλο του κατά την, «ταραχώδη», Μετανακτορική περίοδο.
Ελεύθερη βούληση και ηθική ευθύνη στο πλαίσιο του ντετερμινισμού
Authors: Σωτηρόπουλος Παναγιώτης
Published: December 2022

Η παρούσα διατριβή συνιστά μια προσπάθεια προσέγγισης του προβλήματος της ελεύθερηςβούλησης στη φιλοσοφία του 17ου και 18ου αιώνα. Το μεγαλύτερο μέρος της μελέτης στηρίχθηκεστην ηθική φιλοσοφία του Spinoza. Η ενασχόλησή μου με το συγκεκριμένο ζήτημα προέκυψεαπό την επίμονη αναζήτηση, εκ μέρους μου, μιας θεωρίας της ελευθερίας που να είναι συμβατήμε ισχυρές και δυναμικές εκδοχές ντετερμινισμού. Ο βασικός άξονας τον οποίο ακολουθεί αυτήη εργασία είναι το πώς μπορούμε να καταστούμε ελεύθεροι δίχως την συμβολή της βούλησης,και εντός ενός πλαισίου επιλογών και πράξεων, οι αιτίες των οποίων βρίσκονται σε πρώτοπλάνο; Η φιλοσοφία του Spinoza παρέχει όλους τους μηχανισμούς, όλα εκείνα τα εργαλεία μετα οποία μπορεί κανείς να θεμελιώσει την ελευθερία με ντετερμινιστικούς όρους. Η θέση πουδιατυπώνεται στην παρούσα διατριβή είναι πως η ελευθερία δεν είναι στατική, δηλαδή ηδυνατότητα για διεύρυνση ή συρρίκνωση της ελευθερίας μας είναι αποκλειστικά ανθρώπινηευθύνη και προνόμιο. Η διατριβή διαρθρώνεται σε τρία μέρη: το πρώτο μέρος είναι εισαγωγικόκαι θέτει το θεωρητικό πλαίσιο, το δεύτερο μέρος ερευνά τις θέσεις του Spinoza περί ελευθερίαςκαι το τρίτο μέρος εξετάζει το ζήτημα του ντετερμινισμού.
Arterial hypertension in children and adolescents
Authors: Kawałko Kinga , Rynio Grzegorz , Dubiel Magdalena , Ziojła Kinga , Książek Anna , Sufin Patrycja , Masłocha Aleksander
Published: December 2022

Arterial hypertension is a serious clinical problem in everyday medical practice. It mainly affects adult patients, but is also increasingly common in children and adolescents. Making a diagnosis is possible thanks to systematic measurements of blood pressure during routine medical visits, while maintaining appropriate rules and referring to adequate biological norms - centile charts. Arterial hypertension in children and adolescents may be primary, but much more often than in the adult population, it occurs secondary to diseases of other organs and systems. Early diagnosis of hypertension in the developmental age gives a chance to implement adequate therapy by treating the underlying disease, lifestyle modification or pharmacological treatment. The aim of effective therapy of hypertension is to prevent the occurrence of early and long-term complications of the disease, as well as to reduce the risk of hypertensive emergencies.
Krakowski Kazimierz: Historia i kultura
Authors: Krasnowolski Bogusław
Published: December 2022

Kazimierz, from the 14th century the independent town, and from the turn of the 19th century part of Krakow, is characterised by rich history. Despite unfavourable natural conditions (flood terrace of the Vistula River), the settlement of this area was developed due to the vicinity of Krakow and the Wawel Royal Castle. The oldest settlement was established here at the Saint Michael Church on Skałka, now a late Baroque monument, but at that time (11th century) a Romanesque rotunda, related in the hagiography to the murder of the bishop Saint Stanislaus (1079). Nearby, a settlement was developed – at the Saint James Church (12th century?) which does not exist now. On the eastern side, the village Bawół arouse, mentioned from the 11th century. In 1276, it was located according to the German law due to the efforts of the knight Laurence. The church which does not exist now was dedicated to his patron.
Information Security Policy: Conditions, Threats and Implementation in the International Environment
Authors: Bajor Piotr
Published: December 2022

Information security is one the key aspects of modern security and its importance has been significantly increasing in contemporary international relations. This publication presents the results of studies on several key aspects related to this issue. The publication contains results of research on considerations related to information security and its implementation, as well as research on social media, analysed through the lens of the object and subject of disinformation activities.
Information Security Policy of Ukraine – Assumptions and Effectiveness
Authors: Bajor Piotr
Published: December 2022

The paper presents the results of research on Ukraine’s information security, analysed from the perspective of its tenets, implementation and effectiveness. In this regard, the paper discusses aspects related to the development of conceptual tenets and preparation of a security strategy, as well as sectoral strategies and doctrines of information security and cybersecurity. The paper also contains an analysis of the institutional dimension of information security and actions taken by Ukraine in connection with the Russian aggression in terms of strategic communication and cybersecurity.
Vibrational symmetry of a single molecule revealed by tip-enhanced Raman spectroscopy
Authors: Jaculbia Rafael B. , Imada Hiroshi , Miwa Kuniyuki , Iwasa Takeshi , Takenaka Masato , Yang Bo , Kazuma Emiko , Hayazawa Norihiko , Taketsugu Tetsuya , Kim Yousoo
Published: December 2022

The scanning tunneling microscope (STM) is a powerful tool for studying various nanoscale materials with atomic scale spatial resolution. Despite the atom scale spatial sensitivity however, the STM lacks the chemical sensitivity crucial to the investigation of nanomaterials. Raman spectroscopy on the other hand has a very strong chemical sensitivity but its spatial resolution is highly restricted by the diffraction limit of light allowing only about several hundreds of nanometer resolution. Combining these two powerful experiments into a technique called STM-tip enhanced Raman spectroscopy (STM-TERS) alleviates the limitation of STM and Raman allowing for simultaneous subnanometer spatial resolution and high chemical sensitivity.
Holo-HMD and Remaining Issue
Authors: Sakamoto Yuji
Published: December 2022

Recently, display devices of electro-holography that displays stereoscopic holographic video using digital technology have been prototyped. Especially, holographic head-mounted displays (Holo-HMDs) with light weight and small size have been developed. This paper explains Holo-HMDs, and discusses remining issues for the practical use.
Record High Power Single-Mode Operations of Surface Grating VCSELs
Authors: Hassan Ahmed M. A. , Gu X. , Nakahama M. , Ahmed M. , Koyama F.
Published: December 2022

Due to diverse applications such as LiDAR and 3D sensing, the global market for VCSELs has exploded in recent years
Control and measurement of nano/micro-space temperature that changes cellular behavior
Authors: Nakamura Takayuki , Saito Takaya , Tanimoto Ryuichi , Yamada Takahiro , Funahashi Akira , Taniguchi Atsushi , Nonaka Shigenori , Sakamoto Joe , Kamei Yasuhiro , Tominaga Makoto , Okabe Kohki , Yanase Yuki , Kishi Hiroko , Hiroi Noriko F.
Published: December 2022

To correctly understand various phenomena in living organisms, new insights can be obtained not only by relative observation but also by quantitative measurement of physical parameters.
Outbreak of acute gastroenteritis associated with drinking water in rural Kazakhstan: A matched case-control study
Authors: Orysbayeva Madina , Zhuman Balaussa , Turegeldiyeva Dinara , Horth Roberta , Zhakipbayeva Bakhytkul , Singer Daniel , Smagul Manar , Nabirova Dilyara
Published: December 2022

We conducted an outbreak investigation from June 3 to 15th in a rural village in northern Kazakhstan, after surveillance showed an increase in gastroenteritis. Cases were residents who presented for medical treatment for diarrhea, fever (>37.5 °C), vomiting, or weakness from May 14 to June 15, 2021. Controls were residents matched by age ±2 years at a ratio of two controls for every case. Cases and controls were interviewed using structured questionnaires. We abstracted clinical data from medical records. We mapped cases and assessed risk for disease using conditional multivariable logistic regression. We identified 154 cases of acute gastroenteritis (attack rate of ~26 per 1,000 inhabitants). Symptoms were diarrhea, fever, vomiting, weakness, and decreased appetite. Among cases that participated (n = 107), 74% reported having drank unboiled tap water vs 18% of controls (n = 219). This was the only risk factor associated with disease (adjusted odds ratio: 18; 95% CI 9–35). Drinking water from a dispenser or carbonated drinks was protective. The city has two water supply networks; cases were clustered (107 cases in 79 households) in one. The investigation found that monitoring of quality and safety of water according to national regulations had not been conducted since 2018. No fatalities occurred, and no associated cases were reported after our investigation. Results suggest that untreated tap water was the probable source of the outbreak. The water supply had been cleaned and disinfected twice by the facility 2 days before our investigation began. Recommendations were made for regular monitoring of water supply facilities with rapid public notification when issues are detected to reduce likelihood of future drinking water associated outbreaks.
Cost-effectiveness of monthly follow-up for the treatment of uncomplicated severe acute malnutrition: An economic evaluation of a randomized controlled trial
Authors: Menzies Nicolas A. , Berthé Fatou , Hitchings Matt , Aruna Philip , Hamza Muhammed Ali , Nanama Siméon , Steve-Edemba Chizoba , Shehu Ibrahim , Grais Rebecca F. , Isanaka Sheila
Published: December 2022

Severe acute malnutrition (SAM) is a major source of mortality for children in low resource settings. Alternative treatment models that improve acceptability and reduce caregiver burden are needed to improve treatment access. We assessed costs and cost-effectiveness of monthly vs. weekly follow-up (standard-of-care) for treating uncomplicated SAM in children 6–59 months of age. To do so, we conducted a cost-effectiveness analysis of a cluster-randomized trial of treatment for newly-diagnosed uncomplicated SAM in northwestern Nigeria (clinicaltrials.gov ID NCT03140904). We collected empirical costing data from enrollment up to 3 months post-discharge. We quantified health outcomes as the fraction of children recovered at discharge (primary cost-effectiveness outcome), the fraction recovered 3 months post-discharge, and total DALYs due to acute malnutrition. We estimated cost-effectiveness from both provider and societal perspectives. Costs are reported in 2019 US dollars. Provider costs per child were $67.07 (95% confidence interval: $64.79, $69.29) under standard-of-care, and $78.74 ($77.06, $80.66) under monthly follow-up. Patient costs per child were $21.04 ($18.18, $23.51) under standard-of-care, and $14.16 ($12.79, $15.25) under monthly follow-up. Monthly follow-up performed worse than standard-of-care for each health outcome assessed and was dominated (produced worse health outcomes at higher cost) by the standard-of-care in cost-effectiveness analyses. This result was robust to statistical uncertainty and to alternative costing assumptions. These findings provide evidence against monthly follow-up for treatment of uncomplicated SAM in situations where weekly follow-up of patients is feasible. While monthly follow-up may reduce burdens on caregivers and providers, other approaches are needed to do so while maintaining the effectiveness of care.
Responses of soccer players performing repeated maximal efforts in simulated conditions of the FIFA World Cup Qatar 2022: A holistic approach
Authors: Chmura Paweł , Liu Hongyou , Andrzejewski Marcin , Tessitore Antonio , Sadowski Jerzy , Chmura Jan , Rokita Andrzej , Tański Wojciech , Cicirko Leszek , Konefał Marek
Published: December 2022

This study aimed to assess the capacity for repeated maximal effort (RME) of soccer players in the thermo-natural conditions (NC) and in simulated conditions for the 2022 FIFA World Cup in Qatar (QSC). Twenty-four semi-professional soccer players participated in the study. The exercise test consisted of ten 6-second maximal efforts on a cycloergometer. A 90-second passive rest interval was used. The test was performed in a Weiss Technik WK-26 climate test chamber in two different conditions: 1) thermo-neutral conditions (NC—20.5°C; 58.7% humidity); and 2) simulated conditions for the 2022 World Cup in Qatar (QSC—28.5 ± 1.92°C; 58.7 ± 8.64% humidity). Power-related, physiological, psychomotor, blood, and electrolyte variables were recorded. Results showed that (1) players achieved higher peak power (max 1607,46 ± 192,70 [W] - 3rd rep), needed less time to peak power (min 0,95 ± 0,27 [s] - 3rd rep), and had a higher fatigue slope (max 218,67 ± 59,64 [W/sek] - 7th rep) in QSC than in NC (in each repetition of study protocol); (2) between the 1st repetition and subsequent repetitions a number of significants in among physiological, blood-related, and electrolyte variables were noted, but their direction was similar in both simulated conditions (e.g. V’O2/kg 37,59 ± 3,96 vs 37,95 ± 3,17 [ml/min/kg] - 3rd rep, LAC 13,16 ± 2,61 vs 14,18 ± 3,13 [mg/dl] - 10th rep or K 4,54 ± 0,29 vs 4,79 ± 0,36 [mmol/l] - 2nd rep when compare QCS and NC respectively); (3) an 8°C of temperature difference between the climatic conditions did not significantly affect the soccer players’ physical and physiological responses in RME. The study results can be used in the design of training programs aimed to increase players’ physiological adaptations by simulating soccer-specific conditions of play in terms of anaerobic capacity, in particular, repetitive maximal efforts. These findings will be useful during the upcoming 2022 World Cup in Qatar and in locations where high ambient temperatures are customary.
Effectively computing transition patterns with privacy-preserved trajectory datasets
Authors: Kim Jong Wook , Jang Beakcheol
Published: December 2022

Recent advances in positioning techniques, along with the widespread use of mobile devices, make it easier to monitor and collect user trajectory information during their daily activities. An ever-growing abundance of data about trajectories of individual users paves the way for various applications that utilize user mobility information. One of the most common analysis tasks in these new applications is to extract the sequential transition patterns between two consecutive timestamps from a collection of trajectories. Such patterns have been widely exploited in diverse applications to predict and recommend next user locations based on the current position. Thus, in this paper, we explore the computation of the transition patterns, especially with a trajectory dataset collected using differential privacy, which is a de facto standard for privacy-preserving data collection and processing. Specifically, the proposed scheme relies on geo-indistinguishability, which is a variant of the well-known differential privacy, to collect trajectory data from users in a privacy-preserving manner, and exploits the functionality of the expectation-maximization algorithm to precisely estimate hidden transition patterns based on perturbed trajectory datasets collected under geo-indistinguishability. Experimental results using real trajectory datasets confirm that a good estimation of transition pattern can be achieved with the proposed method.
Impact of the COVID-19 pandemic on physical therapy practice in Saudi Arabia
Authors: Elsayed Walaa , Albagmi Faisal , Hussain Mehwish , Alghamdi Mohammed , Farrag Ahmed
Published: December 2022

Purpose

The new Coronavirus (COVID-19) pandemic has caused significant impact on the medical sector worldwide, including physical therapy (PT). The purpose of this study was to investigate the impact of the COVID-19 pandemic on the PT services, and the associated psychological distress endured by PT practitioners in Saudi Arabia.

Methods

A cross-sectional study was conducted to survey on-duty PT practitioners using a web-based questionnaire. Licensed PT practitioners working in Saudi Arabia (n = 265) participated and completed all the survey questions. The questionnaire comprised 30 questions covering the sociodemographic data and the outcome measures, which included the impact of the pandemic on the PT practice, use of telerehabilitation, administrative response during the pandemic, and PT practitioners’ anxiety measured by the General Anxiety Disorder-7 scale.

Results

During the lockdown, disruptive impact on the PT practice was reported by most of the participants (80%). The majority of PT clinics/departments were either partially (43.8%) or completely (31.3%) shutdown, and therapists treated patients less than usual. Around 30% of participants reported using a telerehabilitation approach during the pandemic to communicate with patients, and about 33% received online courses and webinars to adapt the PT practice in response to the pandemic. About 21% of participants endured moderate to severe levels of anxiety, which was more pronounced among females.

Conclusion

The COVID-19 pandemic significantly impacted the PT services in Saudi Arabia. Consequently, the number of patients treated was reduced, and therapists suffered notable psychological stress. Furthermore, although implemented, adaptive administrative measures were inadequate. Physical therapy practitioners and administrative authorities are encouraged to prioritize training and implementation of telerehabilitation as a likely prospective approach of PT practice.
Agronomic treatments to avoid presence of seeds in Nadorcott mandarin II. Effect on seed number per fruit and yield
Authors: Garmendia Alfonso , Raigón María Dolores , García-Breijo Francisco , Reig José , Beltrán Roberto , Zornoza Carlos , Cebrián Nuria , Merle Hugo
Published: December 2022

Nadorcott is a well-established and appreciated mandarin by the fresh market. However, it produces seeds due to cross-pollination with other compatible varieties, which is quite frequent in most producing countries. Consumers prefer seedless mandarins and, therefore, citrus growers need techniques to avoid seeds forming. This study aims to evaluate the effect of six treatments (ammonium nitrate, potassium nitrate, sulfur, saccharose, methylcellulose, callose) on seed number per fruit when applied to Nadorcott trees. In this way, we evaluate which of them is more efficient and can be used in the future as an agronomic treatment to avoid seeds in mandarins. The effect of treatments on yield and fruit quality is also reported. To fulfill this main objective, a randomized complete block design experiment with three applications at flowering was performed on trees. Of the six tested treatments, only elemental sulfur was able to significantly reduce seed number by 87% compared to the positive control. This is a very novel result because it is the first time that such an effective treatment has been found. The biggest seed number per fruit was obtained for the saccharose treatment. Treatments did not significantly influence yield or fruit quality. These results are entirely consistent with a previous study that evaluated the effect of the same products on pollen tube growth, and they can help to develop new techniques. Nevertheless, more studies are necessary to test, for example, different treatment doses.
Costs, effectiveness, and safety associated with Chimeric Antigen Receptor (CAR) T-cell therapy: Results from a comprehensive cancer center
Authors: Chacim Sérgio , Monjardino Teresa , Cunha José Luís , Medeiros Pedro , Redondo Patrícia , Bento Maria José , Mariz José Mário
Published: December 2022

Real world effectiveness, toxicity and costs analyses from chimeric antigen receptor (CAR)-T cell therapy are of utmost relevance to determine whether and how to offer patients highly personalized immunotherapy. In this study, we aimed at describing CAR T-cells effectiveness, safety and costs in a Portuguese Comprehensive Cancer Center. We performed a retrospective descriptive study of adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma and transformed follicular lymphoma referred to CAR T-cell therapy, between May 2019 and February 2021. Rates of treatment response, toxicity and survival (Kaplan-Meier method) were analyzed by intention-to-treat. Direct medical costs stratified by inpatient-care, outpatient-care, and diagnostic-therapeutic procedures (DTP) were derived based on resources used and their respective unit costs. In twenty patients (median age 49.5y; 55%male; 70%DLBCL; 50% with primary refractory disease), best overall and complete response rates were 65.0% and 45.0%, respectively. Median overall (OS) and progression-free survivals were 9.2 and 7.3 months; 12-month OS rate was 42.6% (95%CI:23.2–78.3). Grade≥3 cytokine release syndrome and neurotoxicity occurred in 5.6% and 11.1% of patients, respectively. CAR T-cell therapy expenditure, including adverse events costs, was 7 176 196€, or 286 238€ when excluding drug cost. Median cost for treated patient was 355 165€ with CAR T-cell drug cost accounting for 97.0% of the overall expense. Excluding CAR T-cell acquisition cost, inpatient-care and DTP accounted for 57% and 38% of total cost/patient, respectively. Our findings highlight the heavy economic burden of CAR T-cell therapy driven by drug acquisition costs.
Embolization for Perimedullary Arteriovenous Fistulae: Pioneering Experience in Peru
Authors: Plasencia Andrés R. , Solís Frank G. , Santillán Alejandro
Published: December 2022

Background
Perimedullary arteriovenous fistulae, or type IV spinal cord arteriovenous malformations, are very rare and not well-known lesions. This paper aims to present our endovascular experience with these lesions.

Methods
We report our experience with 4 patients with perimedullary arteriovenous fistulae, subtypes b and c (macrofistulae), exhibiting severe neurological impairment. The patients were treated with endovascular embolization.

Results
Complete fistula eradication was achieved in all of them. One complication occurred. We discuss the natural history, pathophysiology, clinical presentation, prognosis and embolization techniques, along with the angiographic and clinical outcomes.

Conclusion
Our experience with endovascular embolization as an upfront treatment allowed us to eradicate these lesions in a safe and effective way, arresting the clinical worsening and reversing partially or completely the neurological injury in most of our cases.
The Trajectory of the Jihad Discourse in Malay World: An Analysis on the Baḥr Al-Mādhī by Muḥammad Idrīs Al-Marbawī
Authors: Azid Muhammad Adam Abd. , Mohd Rokhibi Ibrahim Adham , Md Ariffin Mohd Farhan , Ikhlas Rosele Muhammad , Abdul Hamid Mohammad Fahmi
Published: December 2022

The term of jihad has a significant role in the formation of Islamic identity, politics, and nations. For example, the Malay World during the colonial or pre-independence, has created the momentum among community to break free from the colonial at the time. This spirit was injected with elements of jihad through the advice of scholars, graduates returning from the middle east who brought the spirit of independence and through writing. Among the writings that may have a role in explaining jihad among the Malay community is Baḥr al-Mādhī [1924-1960]. This article will analyse on the representation of jihad and warfare term in the Baḥr al-Mādhī, a book written by Muḥammad Idrīs al-Marbawī [1896-1989]. It can be considered as one of the greatest masterpieces of Malay Muslim scholar in the twentieth century. It was composed as a commentary to the hadith in Jāmi‘ al-Tirmidhī and have been written in Malay language. This article also analyses al-Marbawi’s contribution to Malay community understanding jihad in pre independence period of Malaysia through his commentary and translation of the hadith of jihad in Baḥr al-Mādhī. This study applied qualitative study, data collected by library research and analysed by document analysis methodology. Study found that, the Baḥr al-Mādhī by Muḥammad Idrīs al-Marbawī has played a major role in the understanding of jihad among Malays in pre-independence period. This book symbolizes the local wisdom of the Malay community at the earliest time. This contribution can be understood through the background of the writing of this book, its wide pertinence into society and the content of jihad in it.[Konsep jihad mempunyai peran signifikan dalam pembentukan identitas keislaman, politik dan kebangsaan. Misalnya seperti dunia Melayu pada masa kolonial atau pra kemerdekaan dimana sarjana muslimnya yang pulang dari belajar di Timur Tengah mendorong masyarakatnya berjuang melawan kolonialisme dan menuntut kemerdekaan melalui tulisan mereka. Salah satu tulisan yang menerangkan konsep jihad dalam masyarakat Melayu adalah Baḥr al-Mādhī. Artikel ini menjelaskan konsep jihad dan perang dalam karya Baḥr al-Mādhī, satu karya terbaik sarjana muslim Melayu abad 20, yang ditulis oleh Muḥammad Idrīs al-Marbawī (1896-1989). Karya ini merupakan komentar terhadap kitab hadist Jāmi‘ al-Tirmidhī yang ditulis dalam bahasa Melayu. Artikel ini juga membahas kontribusi penting al-Marbawī dalam menjelaskan jihad dalam masyarakat Melayu masa pra kemerdekaan. Dengan studi literatur dan analisis dokumen terkait, artikel ini menunjukkan bahwa karya al-Marbawī merupakan simbol dari kearifan lokal masyarakat Melayu pada masa awal. Kontribusi pentingnya terlihat dari luasnya pengaruh dan pendalaman pemahaman tentang jihad di masyarakat Melayu saat itu.]
Un gesuita spagnolo in Cina
Authors: Lombardi Federico
Published: December 2022

L’articolo offre una visione d’insieme della vita e dell’opera di Diego de Pantoja (1571-1618), uno dei pionieri della missione gesuitica in Cina. Seguendo la strada aperta da Francesco Saverio, Diego de Pantoja raggiunse Pechino al seguito di Matteo Ricci, entrando in contatto con i letterati cinesi attivi nella corte imperiale e riuscendo così a dare alla missione la necessaria stabilità. Partendo dagli anni di formazione giovanile per giungere, attraverso l’epoca di attività missionaria svolta a Pechino come collaboratore prima e successore poi del padre Matteo Ricci, sino alla persecuzione di Nanchino, l’esilio e la morte avvenuta a Macao, il testo prende in esame i principali contributi offerti da Diego di Pantoja alla causa missionaria, tra cui la stesura della Relación de la entrada de algunos padres de la Compañia de Jesús en la China e de Le sette vittorie sui sette peccati capitali (Qikedaquan) e la riforma del calendario.
Modern and Lightweight Component-based Symmetric Cipher Algorithms
Authors: Qassir Samar A. , Gaata Methaq T. , Sadiq Ahmed T.
Published: December 2022

Information security, being one of the corner stones of network and communication technology, has been evolving tremendously to cope with the parallel evolution of network security threats. Hence, cipher algorithms in the core of the information security process have more crucial role to play here, with continuous need for new and unorthodox designs to meet the increasing complexity of the applications environment that keep offering challenges to the current existing cipher algorithms. The aim of this review is to present symmetric cipher main components, the modern and lightweight symmetric cipher algorithms design based on the components that utilized in cipher design, highlighting the effect of each component and the essential component among them, how the modern cipher has modified to lightweight cipher by reducing the number and size of these components, clarify how these components give the strength for symmetric cipher versus asymmetric of cipher. Moreover, a new classification of cryptography algorithms to four categories based on four factors is presented. Finally, some modern and lightweight symmetric cipher algorithms are selected, presented with a comparison between them according to their components by taking into considerations the components impact on security, performance, and resource requirements.
RENEWAL OF THE CONSTITUTIVE NATIONAL LAW SYSTEM IN INDUSTRIAL DESIGN
Authors: Waspiah Waspiah
Published: December 2022

The regulation of industrial design in Indonesia is still experiencing several challenges, one of which is regarding the legal system. This paper aims to analyze the reform of the constitutive national legal system on industrial design in Indonesia. This paper confirms that the requirements for legal protection with a Constitutive system on industrial design by MSMEs required by law, if they are still used in the current era, where world developments are very fast, do not reflect the national legal system, so that what should be based on Pancasila as a legal ideal. An alternative step in bridging is to internalize Pancasila values into the Industrial Design Law as a spirit or soul which is expected to be able to provide justice for the Design Community (MSMEs).