bluuebunny/crossref_metadata_2025 huggingface dataset:
PROGNOSTIC VALUE OF SOME INDICES OF LIFE QUALITY IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE IN CORRELATION WITH INFLAMMATORY STRESS MARKER
Authors: Kostenko V A , Skorodumova E A , Skorodumova E G , Rysev A V , Dymnikova N A
Published: May 2018

The article describes the study of the quality of life in patients with acute decompensated heart fail- ure and comparison of data and a visual analogue scale of Kansas questionnaire in patients with acute decompensated heart failure and also their correlation with known prognostic factors such as level of inflammatory stress markers. Since there can not be a 'gold standard' profiles, their validity can be estimated taking into account the coefficient of correlation data profiles with the prognosis. To assess the quality of life parameters, a Kansas questionnaire was used. Each item was evaluated by patients in1 to 6 points.. Prognostically unfavorable in the questionnaire were the marks from 1 to 3. According to the results of the study, it was shown that the QOL questionnaire can serve not only as a marker for assessing the patient's treatment, but also as an indicator of the medium-term vital prognosis. Correla- tion of these parameters of QOL with objective parameters reflecting the function of the left ventricle, comorbid status (primarily, the state of the kidneys), as well as signs of inflammatory stress are noted.
SWEAT AND FAT TRACES OF THE PERSON AS OBJECT OF DNA IDENTIFICATION OF THE PERSONALITY
Authors: Faleeva T G
Published: May 2018

In the review possible sources of dNA in sweat and fat substance are provided, and skin of the person is considered not only as a source of biological allocations, but also as a specific surface on which there is a possibility of detection of foreign imposings of a biological origin. The analysis of the existing methods of detection, fixing, collection, transportation and the subsequent molecular and genetic research dNA-containing of sweat and fat substance of the person is carried out. Approach to interpretation of results of genotyping of the biological objects containing small amount of genetic material is determined.
PECULIARITIES OF DEVELOPMENT OF BEHAVIORAL FUNCTION IN CHILDREN WITH DIFFERENT TYPES OF FEEDING UNDER STRESSFUL CONDITIONS
Authors: Ershova I B , Shirina T V , Goncharova T A
Published: May 2018

The aim of the research is to study the state of behavioral function in infants who were born and living in the Lugansk and donetsk during the military conflict. A dynamic clinical examina- tion was made. Also it was made the assessment of the rate of behavioral development in 68 children in the area of military conflict. Among them 32 children were breast-fed, forming Ia (the main) group of children, and 36 children who were bottle-fed, forming the comparison group Ib. The control groups of our study consist of 88 children who were outside the zone of military conflict. Among them there were 47 children who were breast-fed (IIa group), and 41 children who were bottle-fed (IIb group). The assessment of the level of behavioral function development in children was carried out using a standard- ized clinical-psychological techniques "Gnome".Conclusions: The development of behavioral functions in infants and toddlers depends on the sur- rounding stressful conditions and the type of feeding. The level of formation of these functions in chil- dren who were bottle-fed and under stress of war was the lowest. The greatest delay in children of this group were the indicators of social development. From biological indicators much more suffered the functions associated with eating behavior. Children who were bottle-fed in the stress of military actions in infancy and early childhood are in need of rehabilitation activities.
VERIFICATION AND TREATMENT OF RESISTANT CHRONIC RHINOSINUSITIS WITH NASAL POLYPS AT MULTIMORBID CARDIOVASCULAR PATHOLOGY
Authors: Aflitonov M A , Artyushkin S A , Partsernyak S A , Mironenko A N , Partsernyak A S , Naumov S Y , Bezrukova E V , Topanova A A
Published: May 2018

Objective: Identify the diagnostic signs for chronic rhinosinusitis with nasal polyps (CRSwNP & resistant forms) with multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAd), hypertension, metabolic syndrome (MS). Identify effectiveness of photodynamic therapy in CRSwNP treatment. Design and methods: The study included 75 patients (mean age 35,8±7,93, 39,2% - female,60,8% - male) with CRSwNP and MCVP divided into 3 groups by simple random sampling. Patients in group 1 (n = 27) received standard therapy CRSwNP, hypertension, CAd, NPMd, 8-weeks anti- bacterial and leukotriene receptor antagonists treatment. Surgical interventions history of the last 5 five years: from 1 to 2. Patients in group 2 (n = 28) received standard therapy CRSwNP, hypertension, CAd, NPMd, 8-weeks antibacterial and leukotriene receptor antagonists treatment. Surgical inter- ventions history of the last 5 five years: more than 3. Patients of group 3 (n = 20) received standard therapy CRSwNP, hypertension, CAd, NPMd, 8-weeks antibacterial treatment, 8-weeks leukotriene receptor antagonists treatment and sessions of photodynamic therapy of the paranasal sinuses. Surgical interventions history of the last 5 five years: more than 3. used in the study: complex psychological test methods, ENT and laboratory-instrumental evaluation of the cardiovascular system. Results: depres- sion was detected in 46,3%, 71,9%, 58,3% of patients, (first, second, third groups). Types «non-dipper» and «night-peaker» found in patients 2nd and 3rd groups- corresponds with (CRSwNP & resistant forms). Bone transformation zone as a result of chronic inflammation within the ethmoidal labyrinth and maxillary sinuses identified in the second and third patients group (85% of cases). The use of pho- todynamic therapy in the resistant CRSwNP forms treatment improves the functional indicators of the nasal cavity and paranasal sinuses. Conclusions: Patients with CRSwNP have symptoms of depression and «non-dipper» and «night-peaker» patterns. All CRSwNP patients are defined trigger points with areas of chronic osteitis and odontogenic osteomyelitis. The use of photodynamic therapy for CRSwNP treatment, reduces the number of CRSwNP recurrence.
PRINCIPLES OF FORMATION IN THE POPULATION HEALTH SAVING BEHAVIOR BASED ON COMPETENCE-ACTIVE APPROACH
Authors: Zelionko A V , Luchkevich V S , Avdeeva M V , Filatov V N
Published: May 2018

The article presents the characteristics of the main risk factors and shows the need to involve the family, educational and medical resources, depending on the features of risk factors affecting different stages of human life. It was found that high medical awareness does not affect negotiability of citizens in medical institutions and adherence to a healthy lifestyle. The high frequency of individuals (35.1%), knowledgeable about the principles of health preservation and able to carry them out, but do not applying their medical knowledge and skills in practice, was revealed. One of the ways to improve adherence of health saving behavior of the population is a dynamic monitoring of the implementation of health recommendations according to the primary accounting documents.
PEDIATRIC ASPECTS OF RENDERING THE EMERGENCYMEDICAL SERVICE IN THE RUSSIAN FEDERATION
Authors: Barsukova I M
Published: May 2018

Questions of the organization of rendering an emergency medical service to the children's population of the Russian Federation are considered. They are connected with a demographic situation in the country - growth of the children's population, decrease in indicators of infantile and maternal mortality. Against common problems of system of rendering an emergency medical service in the country its pediatric link looks rather safe. Protection of motherhood and the childhood was and remains the priority direction of a state policy of our country.
CLINICAL AND Х-RAY PATTERNSOF DESMOPLASTIC FIBROMAOF MANDIBULAR BONE
Authors: Muzykin M I , Iordanishvili A K , Rybakova M G , Bugera V N , Vasiliev S V
Published: May 2018

This article presents the results of the clinical examination of the patient at the age of 41, who has been hospitalized according to the principle of OMC to the department of oral surgery and multi- specialized hospital of stomatology with a rare bone disease which affects the lower jaw -desmoplastic fibroma. The surveillance has been conducted for three years. Clinical characteristics and Хray patterns of the disease were revealed and the results of instrumental and histological studies were shown.
CLINICAL CASE OF MENTAL DISORDERS IN THE DEBUTOF MULTIPLE SCLEROSIS
Authors: Zhulev S N , Toropova A A , Nemykin O N , Fomintseva M V , Garyshina Yu O , Kula I I , Mirzaeva L M
Published: May 2018

In a course of multiple sclerosis neurologic deficit could be overshadowed by psychotic signs such as catatonia, depression and dementia. Thus, ignoring these clinical manifestations can pre- vent early diagnosis of multiple sclerosis. Subsequently, an appropriate treatment will be delayed. In our article we report a case of multiple sclerisos in patient presented initially with catatonia, depression and dementia. Psychiatric, neurological, MRI picture and treatment impact thoroughly throughout the whole observation period are described. This case illustrates that catatonia can be dominating feature in the clinical course of multiple sclerosis and can overshadow other neurologic signs.
EVALUATION OF NONCARDIAC CHEST PAIN
Authors: Dorofeev V I , Monashenko D N , Svirido D A , Savelev A A
Published: May 2018

In the presented review of the current literature a lot of information about differente diagnostic approaches for patients management with a syndrome of noncardiac chest pain were system- atized and generalized.These patients have a diverse set of disease that requires the physician applying a wide range of ad- ditional surveys. In General, doctors need to exclude heart disease in patients who were treated with chest pain. If chest pain is noncardiac, then empirical treatment for gastro-intestinal reasons and the cor- responding assessment of psychogenic causes of chest pain are important for the symptomatology of pa- tients. In particular, primary care physicians should consider - besides the cardiac causes as a possible causes of thoracalgia - possible mental disorders, impaired motility of the upper gastrointestinal tract, problems with the thoracic spine - as a possible causes of thoracalgia. It would be beter to find out the rea- sons of thoracalgia with all available diagnostic tools and then - choose and assign appropriate adequate etiotropic therapy for most effectively cupping the patient's symptoms and reducing health care costs.
THE MEDICAL AND LEGAL ASPECTS OF EFFECTIVENESS EVALUATIONOF THE EXAMINATION AND TREATMENT OF COMPLICATED FORMS OF DIABETICFOOT IN PATIENTS DISSATISFIED WITH THE QUALITY OF MEDICAL CARE PROVIDED
Authors: Movchan K N , Iskhakov R B , Kovalenko A V , Rusakevich K I
Published: May 2018

Medical care quality assessment in patients suffering from ulcerous-necrotic forms of diabetic foot is a rather problematic question, especially in cases of negative disease outcome. Patients fighting against diabetes mellitus and its complications for saving their lives occasionally not only criticize the healthcare organization without a good cause but use civil law procedures, bringing in an indictment accusing healthcare practitioners of unsuitable medical care. The article discusses deonto- logical aspects of providing medical care to patients with diabetic foot dissatisfied with the quality of examination and treatment in healthcare providing institutions. It also demonstrates the medical and legal conflict which arose due to medical care quality assessment in a patient with complicated form of diabetic foot who regularly was consulted and was under the care of different health care practitioners as an in-patient so as an out-patient. The article illustrates that important factors in successful treat- ment of patient with diabetes mellitus are professional engagement and interaction between healthcare providers of specialized centres and healthcare practitioners at the out-patient stage as well as case follow-up with suitable and well-timed correction of glucemia. Special attention should be given to doctor-patient cooperation. Only a multidisciplinatory approach offers the possibility to improve the quality of medical care provided to patients with complicated forms of diabetic foot and to reduce the frequency of complaints to different medical, social and politico-administrative authoritative bodies.
NEURORETINOPROTECTION IN TREATMENT AND REHABILITATIONOF EYE DISEASES IN CHILDREN’S AGE
Authors: Saidasheva E I
Published: May 2018

Presented of own long-term experience and the generalized results of the researches devoted to use of domestic drugs of peptide structure in complex therapy of a number of diseases of an optic nerve and a retina at patients of children's age. Clinical efficiency of a retinalamin as retinoprotector and cortexin as neuroprotector in treatment and rehabilitation the disabling diseases shown: atrophy of the optic nerve, retinopathy of prematurity and degenerative myopia.
CUSTODIOL CARDIOPLEGIA: WHICH PROTOCOL TO PREFER?
Authors: Istomin T A , Kurapeev I S , Mihaleva Y B , Suborov E V , Domanskaya I A , Vasilieva G N
Published: May 2018

In this review we presented data about the basic Custodiol cardioplegia techniques and protocols, adverse site effects and warnings. National and international articles on the use of Custodiol cardiople- gia in cardiopulmonary bypass surgery were analyzed. Based on the previous research data, we are criti- cally reflected the current state of anti-ischemic protection of the myocardium, in particular cardiople- gia. Possible future directions for further scientific research in this field of medicine were identified. In this review we discussed the ways to further improve Custodiol cardioplegia.
HYPERMNESIA EUPHORIA OR ANY OTHER DESIRABLE FROM THE POINT OF VIEW OF THE CONSUMER, A PSYCHOTROPIC EFFECT - FIRST AND LEADING ELEMENT IN THE OCCURRENCE AND PRESERVATION OF THE BODY’S DEPENDENCE ON PSYCHOACTIVE FACTORS
Authors: Baitubayev D G , Baitubayeva M D
Published: May 2018

The work shows the role of the vegetative nervous system (VNS) in the functioning of long-term memory, identity mechanisms of long-term memory in the human evolutionary adaptation and substance dependence. It is shown that, depending on the substance of the body are states like pro- gressive adaptation, that the bodycondition, depending on the chemical and psychogenic psychoactive- factors state of the same circle. It proposed the creation of a branch of medicine that combines study of the dependence of the organism, both on the chemical and psychoactive psychogenic factors. Given the classification of psychoactive factors.Onomastics formulated definitions of terminology changes and additions to be used in a new branch of medicine. Proposed allocation of the International Classifica- tion of diseases separate chapter for the classification of states like progressive adaptation of the body depending on psychoactive factors.
ABOUT VALUE OF CONSCIOUS AND UNCONSCIOUSEMOTIONAL PROCESSES AT MULTIPLE SCLEROSIS
Authors: Reznikova T N , Seliverstova N A
Published: May 2018

Research of conscious and unconscious emotional processes at 167 patients with multiple sclerosis in a condition of remission was conducted. The conscious and unconscious alarm (according to tests Taylor and Lusher), conscious and unconscious aggression (according to Bass-darky test and Hand test) in comparison to indicators of personal scales on the Standardized multidimensional personal questionnaire and the clinical and anamnestic of data was studied. At most of patients the high level of conscious and unconscious anxiety, the increased unconscious aggression at standard values of the general conscious aggression is revealed. The correlation analysis between indicators of emotional pro- cesses of the personality and clinical and anamnestic data revealed reliable interrelation of conscious and unconscious alarm, and also a depression (according to the test of Zung) with the phenomena of personal disadaptation and disease severity while conscious and unconscious aggression (on the general indicators) such relationship was no that is important for psychological diagnostics and rehabilitation.
CHARACTERISTICS OF METABOLISM OF GLUCOCORTICOID HORMONESIN PATIENTS WITH PHEOCHROMOCYTOMA
Authors: Ivanushko M A , Vorokhobina N V , Velikanova L I , Shafigullina Z R
Published: May 2018

The article performs analysis of glucocorticoid hormones data and their metabolites in- vestigated by methods of high-performance liquid chromatography and gas chromatography - mass- spectrometry in 47 patients with pheochromocytoma (РНЕО) and 28 patients with hormone-inactive adenoma of the adrenal cortex. We revealed increased blood levels оf biologically active glucocorticoids and elevation of urine excretion of their tetrahydrometabolites in patients with PHEO. 6 patients with PHEO showed biochemical signs of the autonomous cortisol production. A positive correlation of free normetanephrine excretion with blood cortisol, corticosterone and 11-deoxycortisol and urine excretion of tetrahydrometabolites and cortols and a negative correlation with the urine excretion of tetrahydro-11-dehydrocorticosterone were detected. An increase of the THF/THE and (THF+alloTHF+cortol)/ (THE+allo-THE+ cortolone) ratios may indicate a decrease of 11β-hydroxysteroiddehydrogenase type 2 activity in patients with РНЕО.
PROSPECTS OF ULTRASONOGRAPHY APPLICATION FOR PARATHYROID GLANDS ASSESSMENT IN PATIENTS WITH SECONDARY HYPERPARATHYROIDISM
Authors: Zotova I S , Kholin A V
Published: May 2018

Literature analysis was performed data on possibilities of ultrasonic examination (uS) of the para- thyroid glands (PTG) in the differential diagnosis and determining treatment strategy of secondary hyperparathyroidism. It was indicated that the current PTG hyperplasia can be diagnosed by using a variety of methods, at the same time as the most promising considering ultrasound. The literature data suggests that ultrasonography is a highly informative method for assessing the PTG state in secondary hyperparathyroidism, allowing early detection of changes in the glands, to determine the severity of hy- perplasia, assess variants of morphological changes to select the treatment. uS can also be used to moni- tor and control changes identified in gland state during the therapy. uS is recognized method of choice due to its non-invasiveness, harmless and availability, while computed tomography, magnetic resonance imaging and scintigraphy may become further diagnostic step in the cases of unidentified glands and a suspected ectopic PTG. The use of uS allows additional qualitative and quantitative information about PTG state that can be used to select an adequate method of medical or surgical treatment. Further research is needed to assess the possibilities of applying the uS method in the differential diagnosis of secondary hyperparathyroidism.
CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN PATIENTS WITH SYSTEMICLUPUS ERYTHEMATOSUS WITH ANTIPHOSPHOLIPID ANTIBODY SYNDROME
Authors: Belolipetskaia E A , Beliaeva I B , Mazurov V I , Trofimov E A , Lapin S V
Published: May 2018

Antiphospholipid antibodies (aPL): lupus anticoagulant (LA), anticardiolipin antibodies (aCL) and anti-β2-glycoprotein I antibodies (anti-β2GPI) are found in 12 to 44% of systemic lupus erythematosus (SLE) patients. On average, antiphospholipid antibody syndrome (APS) develops in50% of aPL-positive patients with SLE. The seronegative APS is characterized by the absence of the diagnostic levels of "classical" aPL and by the presence of non-criteria aPL: antibodies against pro- thrombin (aPT), antibodies against annexin V, antibodies against phosphatidylethanoamine (aPE), antibodies to phosphatidylserine/prothrombin complex (aPS-PT) and antibodies against negatively charged phospholipids. The presence of four antibodies (LA + aCT + anti-β2GPI + aPT) is associated with a threefold increase in the risk of thrombosis. The presence of aCL and anti-β2GPI in SLE patients with APS and recurrent thromboses is associated with the HLA dRB1 * 0402.
PERCUTANEOUS REMOVING OF KIDNEY STONE UNDER ONLY ULTRASONIC CONTROL
Authors: Guliev B G , Stetchik E O
Published: May 2018

The study included the outcome of percutaneous treatment for nephrolithiasis in 176 patients, who were divided in two groups. Ninety patients (Group 1) underwent PNCL with combined ultrasound and radiological guidance, 86 patients (Group 2) underwent surgery with only ultrasound guidance. The inclusion criteria were the cases with renal pelvis stones larger than 2,0 cm diameter. Postoperative complications (exacerbation of chronic pyelonephritis, macrohematuria) were observed in 13 (14,4%) patients in Group 1 and in 6 (7,0%) in Group 2. There was no significant differences in effectiveness of PCNL, the volume of blood loss and duration of hospitalization. In Group 1 and Group2 the effectiveness of PCNL was 94,4% and 93,0% respectively. In Group 1, 5 (5,6%) required additional intervention. In Group 2, 6 (7,0%) patients required additional intervention. The efficiency of ultra- sound guided PCNL is comparable with this of conventional PCNL. In addition, the radiation exposure of patients and medical staff is reduced during ultrasound guided PCNL.
ANALYSIS OF THE STRUCTURE OF CARIES MORBIDITY IN CHILDRENWITH VARIOUS SOMATIC PATHOLOGIES
Authors: Catygo E A , Reutskaya K V
Published: May 2018

This study found, that the lowest intensity of dental caries in children 2-5 years old with allergic diseases, and the highest intensity of caries in children with NET disorders. Also, the research has demonstrate, that in 4-5 years there is a significant increase in tooth decay in children.
PECULIARITIES OF DEVELOPMENT OF BEHAVIORAL FUNCTION IN CHILDREN WITHDIFFERENT TYPES OF FEEDING UNDER STRESSFUL CONDITIONS
Authors: Ershova I B , Shirina T V , Goncharova T A
Published: May 2018

The aim of the research is to study the state of behavioral function in infants who were born and living in the Lugansk and donetsk during the military conflict.A dynamic clinical examina- tion was made. Also it was made the assessment of the rate of behavioral development in 68 children in the area of military conflict. Among them 32 children were breast-fed, forming Ia (the main) group of children, and 36 children who were bottle-fed, forming the comparison group Ib.The control groups of our study consist of 88 children who were outside the zone of military conflict. Among them there were 47 children who were breast-fed (IIa group), and 41 children who were bottle-fed (IIb group).The assessment of the level of behavioral function development in children was carried out using a standard- ized clinical-psychological techniques "Gnome".Conclusions: The development of behavioral functions in infants and toddlers depends on the sur- rounding stressful conditions and the type of feeding. The level of formation of these functions in chil- dren who were bottle-fed and under stress of war was the lowest. The greatest delay in children of this group were the indicators of social development. From biological indicators much more suffered the functions associated with eating behavior. Children who were bottle-fed in the stress of military actions in infancy and early childhood are in need of rehabilitation activities.
ASSESSMENT OF THE CURRENT ECONOMIC EFFICIENCY OF TREATMENTOF PATIENTS WITH OSTEOARTHRITIS IN SAINT-PETERSBURG AND ITS PERSPECTIVES
Authors: Povzun A S , Mazurov V I , Povzun K A , Kostenko V A
Published: May 2018

The article analyzed the features of the existing system of treatment’s payment in patients with osteoarthritis. The main features of the billing during the transition of the patients hospitalization pay- ment to the system using diagnostic-related groups defines. The main advantages and disadvantages of these systems are analyzed, ways of the economic results optimization of osteoarthritis patients treat- ment are determined with in connection with the planned transition to payment using the clinical- statistical groups. Presented method of the economic efficiency evaluation of paying for treatment can be recommended for use in any other nosological forms of diseases.
MEDICAL PERSONNEL OF POLYCLINIC AS AN INDICATOROF THE QUALITY OF HUMAN RESOURCES IN THE HEALTH CARE
Authors: Panov V P , Avdeeva M V , Logunov D L , Filatov V N
Published: May 2018

The article presents the main characteristics of the medical personal of a typical city polyclinic, on the basis of which it is possible to get an idea about the quality of medical resources in primary health care. It was found that more than half of the physicians «treatment group» working in primary health care, do not have qualifying category (53,1%), despite the big experience of medical practice (14,7±12,1 years). The presence of the qualifying category does not always objectively reflect the quality of medical resources, as most physicians have great experience of practical work and highly appreciate their individual professional level. Activities of the medical personnel of polyclinics associ- ated with intense working conditions, due to the excessive number of the attached population for the primary health care, work without help of a nurse, remoteness of district territories and high need of the population of primary health care. The main factors that adversely affecting the preventive work with the population should include the intensity of outpatient reception, remoteness of district territories, insufficient study of the medical literature and rare visits to scientific conferences.
MOLECULAR GENETIC CHARACTERISTICS CHILDREN WITH GROWTHHORMONE DEFICIENCY
Authors: Berseneva O S , Glotov A S , Glotov O S , Serebryakova E A , Ivashenko T E , Bashnina E B , Baranov V S
Published: May 2018

Clinical manifestations of heterogeneity of growth hormone deficiency when definitive results of hormonal stimulus test determines the need to search for molecular genetic markers of the disease to form personalized therapeutic algorithms. Molecular genetic analysis in patients with congenital hypopituitarism was carried out by new-generation sequencing (NGS) with "Amplisek" technology. All patients with congenital hypopituitarism, who are in a special registry of Saint Petersburg, were included in this study. differences in the frequency of detection of mutations in patients with multiple anterior pituitary hormone deficiency and in patients with isolated growth hormone deficiency were found. The mutation frequency of diagnosis in genes responsible for congenital hypopituitarism in patients of St. Petersburg were studied.Mutations in genes associated with congenital hypopituitarism were identified in 16.3% of patients with pituitary dwarfism (16 of 98). The most commonly diagnosed mutations are changes in gene PROP1. In carrying out the molecular genetic studies of patients with congenital hypopituitarism is necessary to consider the likelihood of the presence of these rare pathologies such as loss of genes GHSR, ARNT2, BTK. Currently conducting molecular genetic studies in patients with congenital hypopituitarism further predicts development of the disease and, if necessary, adjust the ongoing replacement therapy.
ULTRASOUND INVESTIGATION POSSIBILITIES IN PARATHYROID GLANDSESTIMATION IN SECONDARY HYPERPARATHYROIDISM
Authors: Zotova I S , Kholin A V
Published: May 2018

It was assessed the efficacy of the parathyroid gland (PTG) ultrasonography in secondary hyperparathyroidism (SHRT). The data of 120 patients with the diagnosis of SHPT were analyzed. The majority of patients (44,2%) had chronic glomerulonephritis, 59,2% of patients were on hemodialysis,40,8% - on peritoneal dialysis. In 62,3% of cases, an increase in the size of the glands was found, combined with a change in the echostructure. The amount of PTG in one patient was from 1 to 5, ectopic glands were found in 5,4% of cases. In the majority of patients with hyperplastic PTG (68,3%) the increase in the level of parathyroid hormone was more than 300 pg / ml.diffuse hyperplasia was detected in 37,7% of cases, nodal hyperplasia - in 62,3% of cases. The characteristics of ultrasonography with regard to the detection of nodular hyperplasia in case of inhomogeneity of PTG echostructure are: accuracy - 85,7%; sensitivity - 82,4%, specificity - 86,9%, in terms of determining the size of the PTG, the characteristics of the method are: accuracy - 75,8%; sensitivity- 79,3%; specificity - 68,2%.The conclusion is made that ultrasonography is a highly informative method for diagnosing hyperplasia of the prostate gland in patients with SHPT, which allows timely detection of changes in the glands, determining the severity of hyperplasia, suggesting a morphological variant of the observed changes, and increasing the effectiveness of the operative intervention in the PTG.
VIDEO-ASSISTED GASTROENTEROSTOMY PILORODUDODENAL STENOSISIN PATIENTS WITH SENIOR AND SENIOR AGE
Authors: Glushkov N I , Gorshenin T L , Dulaeva S K
Published: May 2018

Introduction. The immediate results of surgical treatment of 80 patients with pyloroduodenal stenosis of older age groups, operated in the traditional way and with the use of endovideosurgical techniques, were analyzed. An optimal variant of preoperative preparation with inclusion of early enteral therapy and nutritional support was offered, which allowed to reduce the degree of hypovolemia and tissue dehydration, to correct the water-electrolyte balance and acid-base state. The incidence of postoperative complications and mortality in both groups were studied. Individualized surgical tactics that allowed to reduce the number of postoperative complications and lethality were proposed.
THE FEATURES OF MAGNETIC RESONANCE IMAGING IN THE DIAGNOSISOF RECURRENT RECTAL CANCER
Authors: Otochkin V V , Rozengauz E V
Published: May 2018

The article presents the MRI studies results of 138 patients after surgery for colorectal cancer. The recurrence was diagnosed in 48 patients (n=48; 35%) in terms of three to 82 months after surgery. The effectiveness of various pulse sequences and planes, bolus contrast enhancement and dWI was evaluated. The semiotics of recurrence of colorectal cancer were described on various pulse sequences, planes and postcontrast images. The combination of the optimal plane and pulse sequence allowed us to identify the tumor and assess its prevalence, structure and form. diagnostic difficulties were associated with small sizes of recurrence - up to 15 mm; in the event of recurrence in the structure of scarring, the presence of areas of hemorrhage in the tumor structure. The use of dynamic bolus contrast enhancement and additional pulse sequence and planes to the standard protocol in difficult cases didn’t increase the sensitivity and specificity of the study. The sensitivity of the MRI was 89.5%, specificity - 98,9%.
THE POSSIBILITIES OF COMPuTEd TOMOGRAPHY IN ASSESSING THE RISK OF STROKE
Authors: Kotov M A , Sebelev K I , Terent’ev R O
Published: May 2018

Stroke occurs when the blood flow in the brain tissues decreases, causing morphological changes - microcirculation disturbances leading to a change in the density of the substance, which can be visualized using radiation diagnostic methods and based on the data obtained, to identify patients at high risk of stroke. The purpose of this study is to study density of brain stem structures in patients with different stroke outcomes compared to the control group. When analyzing these indicators, a correlation was found between changes in brain stem density and the likelihood of a stroke.
COMPARISON OF DIFFERENT METHOD OF ANALGESIA IN AGED PATIENTSWITH CHRONIC LOW BACK PAIN
Authors: Vasilieva G N , Linkov A L , Kukushkina N O , Dimitrienko F I , Karelov A E
Published: May 2018

Effectiveness of different methods of analgesia was studied in 34 aged patients suffering chronic low back pain. All patients were at age 60 to 86 and were randomized into N-group in which nefopam (60 mg rectally) was administrated and K-group that included patients who received ketoprofen (100 mg rectally). The end-points of this prospective study were decrease of pain intensity after analgesics administration, contentment of therapy, and characteristics of side effects of medications taking (twice daily for three days). We found that pain intensity decreases by 6,3±1,6 in N-group and 6,1±1,3 in K- group (p<0.05 in the both cases) and achieves 0,9±1,4 and 0,9±1,6 in N- and in K-group, respectively (p>0.05 in comparison between groups). No significant differences between groups were in estimation of therapy contentment. No side effects were registered. Thus, our data proved the equal effectiveness of central nonopioid analgesic nefopam and nonselective cyclooxygenise inhibitor ketoprofen for achievement of good analgesia in aged patients with chronic low back pain.
IRON METABOLISM, IRON DEFICIENCY ANEMIA AND CARDIORENALANEMIA SYNDROME IN IN ELDERLY AND OLD PATIENTS
Authors: Bogdanov A N , Shcherbak S G , Pavlovich D , Lomonosova E V
Published: May 2018

Modern information about iron metabolism, features of iron deficiency anemias and cardiorenal anemia syndrome in elderly and old patients are revelealed in this lecture.
THE CORRELATION BETWEEN INFLAMMATION MEdIATORS ANd MYOCARdIAL CONTRACTILITY IN PATIENTS WITH ACuTE CORONARY SYNdROME.THE IMPACT OF EARLY INTENSIVE STATIN THERAPY
Authors: Shalnev V I , Mazurov V I
Published: May 2018

The article highlights the impact of early intensive statin therapy on myocardial contractility in patients with acute coronary syndrome. 303 patients with ACS were enrolled in the study. All patients were randomized into two groups. 156 of them received early statin therapy by atorvastastin (80 mg/ day) or simvastatin (40 mg/day) starting from the first day of hospitalization. 147 patients received standard therapy (the control group). The left ventricle ejection fraction was assessed by echocardiography on 12-14 day of disease and after 6 months. The first assessment reveаled no significant difference between groups, while the second examination found better EF results in patients treated with high doses of statins. The statistical analysis was performed to estimate the correlation between inflammation markers and myocardial function. The negative relationship between several inflammation markers and myocardial contractility was revealed. The most significant relationship was found between LV EF and CRP and IL-6 levels. The role of inflammation markers in pathogenesis of ACS and possible mechanisms of early intensive statin therapy effect on myocardial function are being discussed.
INFLUENCE OF BRAIN BASAL CHOLINERGIC SYSTEM DYSFUNCTIONON THE CONDITION OF COGNITIVE FUNCTIONS (LITERATURE REVIEW)
Authors: Lobzin S V , Sokolova M G , Nalkin S A
Published: May 2018

This article is dedicated to the impact of dysfunction of the basal cholinergic system on the state of cognitive functions in various diseases of the brain. domestic and foreign literature is completely reviewed. The pathogenetic mechanisms of dysfunction cholinergic system of the brain are described in myasthenia gravis. Modern approaches in the treatment of cognitive impairment with using central cholinomimetics are described.
A REVIEW OF FOREIGN LITERATURE ON INSTABILITY OF THE LUMBAR SPINE
Authors: Mooraby Z , Ptashnikov D A , Masevnin S V , Michaylov D A , Zaborovskii N S , Volkov I V , Yang L
Published: May 2018

Spinal instability is a pathological condition, which is based on the mechanical displacement of the vertebrae relative to each other, accompanied by pain in the corresponding region of the spine. This pathology is often the determining factor in establishing the indications for surgical stabilization of the vertebral-motor segments. Although instability of the lumbar spine, has been discussed in literature it still hasn’t been sufficiently studied.
MODERN SURGERY OF NON-TRAUMATIC INTRACEREBRAL HEMORRHAGE
Authors: Yarikov A V , Morev A V , Lavrenuk A N
Published: May 2018

In this publication, the authors provide an overview of the literature devoted to modern methods of surgical treatment of non-traumatic intracerebral hemorrhage. Currently under hemorrhagic stroke is meant a wide range of non-traumatic origin of diseases which are accompanied by bleeding in the brain tissue under its shell and / or into the ventricular system. Relevance of the work associated with high mortality (74%) and disability (75-80%) among surviving patients with this pathology. The paper details the etiology and pathogenesis of this type of disorders of cerebral circulation. We describe the surgical technique used in modern neurosurgery. Highlighting their positive and negative sides, given the outcome of treatment of various authors. On the basis of these studies the indications, contraindications, and patient selection criteria for surgical treatment of non-traumatic intracerebral hemorrhage.
VISUALIZATION OF THE DISTRIBUTION OF AUTOLOGOUS MESENCHYMAL CELLS INTRODUCED INTO THE BODY OF A PATIENT SUFFERING FROM CIRRHOSISOF THE LIVER NUTRITIONAL ETIOLOGY
Authors: Kotkas I E , Enukashvily N And , Asadulaev S M , Marchenko N V
Published: May 2018

The article presents own observation about the ability to visualize, entered through its own hepatic artery autologous mesenchymal cells in the human body.
Charachterization of umbilical cord mesenchymal stromal cells during long-term expansion in vitro
Authors: Aizenshtadt A. A. , Skazina M. A. , Kotelevskaya E. A. , Yelsukova L. V. , Zolina T. L. , Ponomartsev N. V. , Galaktionov N. K. , Galembo I. A. , Ivolgin D. A. , Maslennikova I. I. , Enukashvily N. I.
Published: May 2018

One of the clinicians’ major concerns is the biological safety of MSC. The critical question for clinical application of human MSC is their ability to undergo spontaneous malignant transformation in a recipient organism. The goal of our research was to study umbilical cord hMSC proliferative and differentiation capacities, karyotype stability, telomerase activity and telomere length, oncomarkers expression and tumorigenicity during long-term (6 months) cultivation ex vivo. Here we report on the establishing the primary culture of human umbilical cord MSC, MSC_0714, that was capable to proliferate ex vivo for up to 59 passages (6 months). During this period, the cells preserved their normal karyotype, morphology and MSC immunophenotype. Telomeres started to shorten only after the passage 20, while hTERT was inactive in these cells for the whole period of expansion. At the beginning of cultivation the number of SA-β-gal positive cells did not exceeded 3-5%, after the 22th passage their number started to increase and reached 49% at the passage 57. Thus, it was shown that MSC during long-term culture retain their characteristics and undergo cell senescence.
Nutritive correction of insulin resistance and hyperglycemia in acute myocardial infarction
Authors: Alekseenko O. V. , Risev A. V. , Luft V. M. , Kostenko V. A. , Kovalchuk E. Y.
Published: May 2018

Currently the emergency medicine turned on the wide use of the special enteral nutritional cocktails like “Diabetes” to manage different types of hyperglycemia and insulin resistance under various acute disorders. The prognostic value of GH and the effectiveness of its early control in a given target range were studied using these EPS as the only source of nutrition for patients in the acute phase of the course of the first arisen myocardial infarction
Features of the flow of perforations of hollow organs of the abdominal cavity in infectious patients
Authors: Zemlyanoy V. P. , Nakhumov M. M. , Letina Yu. V. , Magomedov G. M. , Shikhmagomedov S. S.
Published: May 2018

In the work of the particularities of clinical course of perforation of hollow organs and peritonitis in conjunction with infectious diseases in patients on treatment in infectious and surgical department compared to patients receiving treatment of perforation of hollow organs in “normal” surgical hospital. Analyzed the differences in the level and nature of perforations, types of peritonitis, infectious diseases have reasons for late diagnosis of these complications.
The role of abdominal hypertension in optimizing the treatment of patients with acute intestinal obstruction
Authors: Glushkov N. I. , Pakhmutova Yu. A. , Belsky I. I. , Safin M. G. , Shchur M. S.
Published: May 2018

The results of examination and treatment of 150 patients with acute intestinal obstruction were studied. A reliable relationship was established between the degree of intra-abdominal hypertension and the severity of the condition of patients with acute intestinal obstruction. The results of our study confirm that monitoring intra-abdominal pressure allows diagnosing acute intestinal obstruction at the initial stages of the disease, determining indications for various modes of operative interventions and the timing of their implementation, predicting the development of possible complications and lethality.
Modern technology in the treatment of patients with postoperative ventral hernias
Authors: Sigua B. V. , Zemlyanoy V. P. , Sokolova A. S. , Cherepanov D. F. , Vinichuk S. A. , Nikiforenko A. V. , Sakhno D. S. , Zakharov E. A.
Published: May 2018

The analysis of results of treatment of 113 patients with postoperative ventral hernias was carried out patients divided into two groups. 74 patients have received treatment (II (control) group) from 2013 to 2014 year. Patients of the control group were examined according to the accepted diagnostic algorithms, in addition to physical examination algorithm include chest and abdominal x-ray examination, ultrasound diagnosis of abdominal organs and fibro-esophagogastroduodenoscopy. Plastic by reticular endoprostheses was carried out in various methods. Methods have been chosen directly by surgeon during the operation. The draining of the postoperative wound was mandatory. Main (I) group included 39 patients who received treatment from 2015 to 2016. The diagnostic algorithm was supplemented with fibrocolonoscopy and spiral computed tomography, and the plastic method was predominantly sub-lay. Hypoderma treatment by high-temperature oscillating plasma flow energy according to the original technique for the prevention of lymphorrhea was provided to all patients. Maims were mostly sutured tightly. This approach allowed to reliably reduce frequency complications from 13.4% (14) to 1.8% (2) and, as a consequence, the length of stay of the patient in the hospital.
Central anticholinergic syndrome following general anaesthesia: prevention and treatment with galantamine
Authors: Danilov M. S. , Lebedinskii K. M. , Kurapeev I. S.
Published: May 2018

Prolonged emergence, excitation and shivering after general anaesthesia are well-known, though only in German-speaking countries they are considered to be forms of single central anticholinergic syndrome (CAS), while in others this term is not associated with general anaesthesia. In Russia the problem is augmented with lack of physostigmine — the first choice for CAS in Germany. We present our analysis of implementing galantamine instead of physostigmine for CAS prevention and management while administering this drug for decurarization. 130 patients undergoing general anaesthesia were divided into three groups depending on decurarization — group I (n = 54) without decurarization, in group II (n = 29) we used galantamine, in group III (n = 47) — neostigmine. In all the groups we assessed CAS incidence and its galantamine treatment effectiveness. Diagnostic criteria for CAS comatose form was unconsciousness 5 min later reaching inhalational agent zero end-expiratory concentration. Using the criteria we found CAS incidence in group I was 26,9%, in group II there were no cases of the syndrome, in group III the incidence was 14,9%. Thus, galantamine 0,3–0,4 mg · kg–1 (max 0,78 mg · kg–1) IV not only prevents CAS but is also effective in its treatment.
Congenital hypopituitarism in children. Molecular-genetic characteristics
Authors: Berseneva O. S. , Glotov A. S. , Glotov O. S. , Serebryakova E. A. , Ivashenko T. E. , Turkunova M. E. , Bashnina E. B. , Baranov V. S.
Published: May 2018

In connection with the ambiguity in the interpretation of the results of stimulation tests in congenital hypopituitarism, children need to search for molecular genetic markers of the disease. Molecular genetic analysis in patients with congenital hypopituitarism (genes GH1, GHRH, GHRHR,BTK, GHSR, PROP1, POU1F1, HESX1, LHX3, LHX4, SOX3, SOX2, OTX2, GLI2, ARNT2, ARPC5L, DLK1, DRD2, PAX6, RNPC3, SHH, SPCS2, SPCS3), was carried out by new-generation sequencing (NGS) with “Amplisek” technology. All patients with congenital hypopituitarism, who are in a special registry of Saint Petersburg, were included in this study. A difference in the incidence of mutations in patients with multiple deficiency of adenohypophysis hormones (27.7%) and in patients with isolated growth hormone insufficiency (9.6%) was revealed. The mutation frequency of diagnosis in genes responsible for congenital hypopituitarism in patients of Saint Petersburg were studied. Mutations in genes associated with congenital hypopituitarism were identified in 16.3% of patients with pituitary dwarfism (16 of 98). The most commonly diagnosed mutations are changes in gene PROP1. In carrying out the molecular genetic studies of patients with congenital hypopituitarism is necessary to consider the likelihood of the presence of these rare pathologies such as loss of genes GHSR, ARNT2, BTK. Currently conducting molecular genetic studies in patients with congenital hypopituitarism further predicts development of the disease and, if necessary, adjust the ongoing replacement therapy.
The representation of postinfarction myocardial rupture
Authors: Kovalchuk E. Yu. , Rysev A. V. , Kovalchuk Y. A. , Alexeenko O. V.
Published: May 2018

The article presents a literature review of the modern conception of postinfarction rupture of the myocardium and predictors of its development.
The peculiarities of brain bioelectrical activity in infants who suffered from stress due to military conflict depending on type of feeding
Authors: Shirina T. V. , Ershova I. B.
Published: May 2018

The aim of the research is to study the peculiarities of brain electrical activity in infants who suffered from stress due to military conflict and who were on different types of feeding.

An electroencephalographic study was conducted in 68 infants who were in the military conflict zone and formed the main group. These infants were divided into 2 subgroups. Subgroup Ia included 36 infants who were breastfeeding. Subgroup Ib included 32 infants who were on artificial feeding. EEG was also made to 88 children who made up a control group and were outside the zone of military conflict. Of these, 47 children were breastfed, who entered the subgroup IIa and 41 children were on artificial feeding, included in subgroup IIb.

The study was carried out with the help of a hardware-software complex for recording and processing electroencephalograms and evoked potentials DX-NT 32.

The most pronounced physiological changes in brain bioelectrical activity were detected in the group of children undergoing stress of war and being on artificial feeding, which were manifested by lower parameters of the amplitude, frequency and time index of alpha and beta rhythms, increased amplitude, frequency and time index of delta and theta rhythms.