bluuebunny/crossref_metadata_2025 huggingface dataset:
The treatment with sGC stimulator improves survival of hypertensive rats with volume-overload induced heart failure and cardio-renal syndrome
Authors: Gawrys Olga , Husková Zuzana , Škaroupková Petra , Honetschlägerová Zuzana , Vaňourková Zdeňka , Kikerlová Soňa , Melenovský Vojtěch , Bačová Barbara Szeiffová , Sykora Matúš , Táborský Miloš , Červenka Luděk
Published: March 2023

Purpose: Heart Failure (HF) has been declared as global pandemic and current therapies are still ineffective, especially in patients that develop concurrent cardio-renal syndrome. Considerable attention has been focused on the nitric oxide (NO)/ soluble guanylyl cyclase (sGC)/ cyclic guanosine monophosphate (cGMP) pathway. In the current study we aimed to investigate the effectiveness of sGC stimulator (BAY41-8543) with the same mode of action as vericiguat, for the treatment of heart failure (HF) with cardio-renal syndrome.
Methods: As a model we chose heterozygous Ren-2 transgenic rats (TGR), with high-output heart failure, induced by aorto-caval fistula (ACF).The rats were subjected into three experimental protocols to evaluate short term effects of the treatment, impact on blood pressure and finally the long term survival lasting 210 days. As control groups we used hypertensive sham TGR and normotensive sham HanSD rats.
Results: We have shown that the sGC stimulator effectively increased the survival of rats with HF in comparison to untreated animals. After 60 days of sGC stimulator treatment the survival was still 50% compared to 8 % in the untreated rats. One week treatment with sGC stimulator increased the excretion of cGMP in ACF TGR (109±28 nnmol/12h), but the ACE inhibitor decreased it (-63±21 nnmol/12h). Moreover, sGC stimulator caused a decrease in SBP, but this effect was only temporary (day 0: 117±3; day 2: 108±1; day 14: 124±2 mmHg).
Conclusion: These results support the concept that sGC stimulators represent a valuable class of drugs to battle heart failure especially with cardio-renal syndrome.
Influence of gamma irradiation pre-sowing treatments on the seeds yield of Moringa oleifera
Authors: Mansour Hanan M. , Hamideldin Nahla , Hassan Yousra E. , Saleh Osama M.
Published: March 2023

Pre-sowing treatment of Moringa oleifera seeds by gamma radiation doses (0, 20, 40 and 60, Gy) to study the changes in yield characters. The yielded seeds phytochemical constituents were detected by Gas Chromatography Mass Spectrometry (GC-MS) analysis. Also, the antioxidant compound (phenols and flavonoids) using Spectrophotometer and changes in DNA were detected using Inter-Simple Sequence Repeats (ISSRs). Genomic template stability percentage (GTS %) of DNA were calculated. Significant increases were observed in yield characters under gamma irradiation, also there were changes in the yielded seeds phytochemical constituents, phenol and flavonoid content significantly increased under irradiation comparing to the control (0Gy). Some unique bands as a result of gamma irradiation were detected using (ISSRs). The irradiation treatments 20Gy, 40Gy and 60Gy revealed changes in the number of amplified DNA bands comparing to the control. The changes reflected by the appearance of new bands and disappearance of bands, the lowest GTS (42.86%) recorded with 60Gy treatment, while the highest GTS (55.84%) recorded with 20 Gy treatment. Pre-sowing irradiation for seeds of the medicinal plant Moringa oleifera by gamma rays increase the yield of moringa tree also induced changes in seeds phytochemical constituents and increasing the antioxidant compounds (phenols and flavonoids). Alternations in DNA induced by gamma irradiation can be detected by ISSRs molecular marker.
Ontologies for Supporting Traffic Behaviour, Critical Gap, and Conflict Models at Unsignalized Intersection Routes
Authors: Mustakim Fajaruddin , Ahmad Mohammad Nazir , Aziz Azlan Abdul , Jamian Saifulnizan , Mahmud Azwan , Kadir Rabiah Abdul , Sulaiman Riza
Published: March 2023

Background: The challenge arises from management of big data in transportation can be identified by ontological approach. Road accidents are regarded as a significant cause of both harm to humans and financial damage in many countries. In Malaysia, there were 567,516 accidents in 2020 alone. This translates into a daily average of 13 people killed due to traffic accidents in the country. Here, our work focuses on gap patterns, critical gap analysis, gap acceptance of right-turning motorists (RTMs) and serious conflict model on Malaysia Rural Roadways at three-leg unsignalized intersections.
Methods: In early stage, traffic volume, motorist turning manoeuvre and speed study are implemented to identify the traffic behaviour at selected intersection. Three unsignalized intersection (UI) was involved namely (UI2), (UI 9), and (UI10). In the development of logistic regression models, five different datasets were used in this study: right-turning motorist (RTM) at unsignalized intersection UI2 (259 dataset), right-turning motorist at UI 9 (239 dataset), right turning motorist at UI 10 (314 dataset), right turning motorist combined model (812 dataset) and serious conflict lane change (351 dataset). Determination of critical gap was carried out at each unsignalized intersection 2, 9 and 10. Meanwhile gap-pattern analysis at each intersection used visualization spatial plot. In addition, this work investigated logistic regression method, artificial neuron network and structural equation modelling.
Results: Gap pattern three was discovered to be a vulnerable gap pattern. Furthermore, this research reveals that the attributes of the gap three pattern, motorcycles rider, speed limit exceeding 50 kph and RTMs where motorcycles stop near passenger cars in minor roads encourage serious conflict. Moreover, this study propose novelty tool for identifying hazardous unsignalized intersection by using visualization spatial plot between approach speed and gap.
Leading and Trailing Edge Configuration for Distributed Electric Propulsion Systems
Authors: Eqbal Mithun , Marino Matthew , Farley Patrick
Published: March 2023

In pusher-type aircraft, the impact of putting the propeller on the trailing edge and impact of propeller on the tip of the wing has been carefully researched. The results reveal an increase in propelling efficiency and a reduction in drag. In addition, there is a lot of study being done right now on distributed propulsion and the advantages it has in terms of aerodynamic effects and propelling advantages. This paves the way for the possibility of positioning the propeller on the trailing edge of the wing and using the increased propulsive efficiency afforded by boundary layer ingestion (BLI). This research studies the effect of positioning the propeller on the trailing edge of the wing instead of the leading edge on power savings and advances in propulsive efficiency. A scaled Remotely Piloted Aircraft Systems (RPAS) wing is tested in a wind tunnel utilising a Brushless Direct Current (BLDC) engine with several propeller configurations. A new term, Ingestion Ratio (IR), is introduced to describe the effect of the change in propeller size on power savings. The investigation revealed that positioning the propeller on the trailing edge of the wing increases the propelling efficiency by up to 5.8% and saves up to 24.7% of electricity.
Crystal structure, hydrogen bonding, and high-pressure behavior of the hydroxide perovskite MgSi(OH)6: A phase relevant to deep subduction of hydrated oceanic crust
Authors: Welch Mark D. , Najorka Jens , Wunder Bernd
Published: March 2023

The structural response to compression of the synthetic high-pressure hydroxide perovskite MgSi(OH)6, the so-called “3.65 Å phase,” has been determined to 8.4 GPa at room temperature using single-crystal XRD in the diamond-anvil cell. Two very similar structures have been determined in space groups P21 and P21/n, for which differences in oxygen donor-acceptor distances indicate that the non-centrosymmetric structure is likely the correct one. This structure has six nonequivalent H sites, of which two are fully occupied and four are half-occupied. Half-occupied sites are associated with a well-defined crankshaft of hydrogen-bonded donor-acceptor oxygens extending parallel to c. Half occupancy of these sites arises from the averaging of two orientations of the crankshaft H atoms (|| ±c) in equal proportions. The P21 and P21/n structures are compared. It is shown that the former is likely the correct space group, which is also consistent with recent spectroscopic studies that recognize six nonequivalent O-H. The structure of MgSi(OH)6 at pressures up to 8.4 GPa was refined in both space groups to see how divergent the two models are. There is a very close correspondence between the responses of the two structures implying that, at least to 8.4 GPa, non-centrosymmetry does not affect compressional behavior. The very different compressional behavior of MgO6 and SiO6 octahedra observed in this study suggests that structural phase transformations or discontinuities likely occur in MgSi(OH)6 above 9 GPa.
Ni-B/TiC Nanokompozit Kaplamaların Korozyon Dayanımlarının Elektrokimyasal Empedans Spektroskopisi (EES) Yöntemi ile Analizi
Authors: ÜNAL Ersin , YAŞAR Abdulkadir , KARAHAN İsmail Hakkı
Published: March 2023

Makine parçaları korozyon ve aşınma gibi malzeme yüzeylerinde hasara neden olan çeşitli etkilere maruz kalmaktadır. Malzeme yüzeylerinin bu zararlı etkilerden korunması için çeşitli ve etkili yöntemler bulunmaktadır. Elektrokimyasal kaplama bu yöntemlerden en çok tercih edilenlerden bir tanesidir. Bu çalışmada, Ni-B alaşımı ana yapısı titanyum karbür (TiC) takviye parçacıkları ile desteklenerek, sanayide kullanımı çok tercih edilen AISI 304 kalite paslanmaz çelik üzerine elektrokimyasal depolama metodu ile kaplanmıştır. Elde edilen bu kaplamaların korozyon dayanımları elektrokimyasal empedans spektroskopisi (EES) yöntemi ile analiz edilmiştir. Mukayese yapmak amacıyla paslanmaz çelik altlığın korozyon direncinin yanı sıra, saf nikel ve Ni-B alaşım kaplamalarda üretilmiş ve korozyon direnci incelenmiştir. Elde edilen sonuçlara göre, Ni-B/TiC nanokompozit kaplamaların Nyquist eğrilerinin, paslanmaz çelik, saf nikel ve Ni-B alaşıma göre çok daha kapsayıcı ve geniş görünümlü olduğu tespit edilmiştir. Aynı zamanda Bode grafiğindeki nanokompozit kaplamalara ait faz açısı değerleri de yine çok daha yüksek elde edilmiştir. Nyquist eğrilerinin eş değer devre uydurma işlemiyle hesaplanan korozyon direnç değerlerine göre, en iyi korozyon dayanımını 12 g/l TiC banyo parçacık içerikli nano kompozit numune sergilemiştir. Bu numunenin direnç değeri paslanmaz çeliğe göre ~%280, saf nikele göre ~%235, Ni-B alaşıma göre ise ~%307 civarlarında daha yüksek elde edilmiştir. Elde edilen bu sonuçlara göre, Ni-B alaşımını TiC ile takviye etmenin korozyondan korunma açısından son derece etkili olduğu anlaşılmıştır.
Disciplina de libras ofertada nos currículos de formação de professores de ciências e biologia de Pernambuco
Authors: Barros Fellipe Pereira , Oliveira Deyla Paula de , Araújo Gustavo Cunha de
Published: March 2023

Este estudo objetivou identificar a oferta da disciplina Libras nos Projetos Pedagógicos de Cursos (PPC), bem como o período, carga-horária e ementas das disciplinas dos cursos de Licenciatura em Ciências Biológicas de Instituições de Ensino Superior (IES) públicas e privadas de Pernambuco. Nesta pesquisa de caráter descritivo, por meio de análise documental e de conteúdo, foi realizada a busca dos PPC e das ementas nas páginas das IES que ofertam os cursos de Licenciatura em Ciências Biológicas no referido estado. Esta pesquisa evidenciou que das 11 instituições de ensino superior pesquisadas, apenas 5 (sendo essas públicas) disponibilizaram as ementas dos cursos que ofertam a disciplina Libras na matriz curricular. Nas análises realizadas, constatou-se que assuntos como a historicidade e a cultura dos surdos na educação, bem como legislações acerca da Libras no sistema educacional brasileiro, são mencionados com maior frequência nas ementas analisadas.
Solubility Enhancement and Antioxidation Maintenance of CBD Encapsulated
in the P407-RUB Nano-micelle System
Authors: Su Yan-Ting , Zhang Jian
Published: March 2023

Aim:

The aim of this study is to improve the water solubility and stability of cannabidiol
(CBD) utilizing micelle technology.

Materials and Methods:

Mixing of rubusoside (RUB) with Poloxamer 407 (P407) was explored as the
wall material for the preparation of CBD micelles. In this study, CBD-loaded mixed micelles (CBD-M)
composed of P407 and RUB was successfully formed by self-assembly then solid were prepared by
solvent evaporation. The saturated solubility of CBD-loaded micelles in water increased to 15.60 mg/mL,
1560-fold compared with its intrinsic solubility (0.01 mg/mL). The average size of CBD-M was 103 ±
2.66 nm and the encapsulation efficiency for CBD was 92.8 + 4.7 %, and 18.6 + 0.94% for drug-loading.

Results:

The morphology and encapsulation of CBD-M were characterized by TEM, FI-IR, DSC and
TG. The CBD-M solution was stable and CBD-M did not precipitate or leak after being diluted and
centrifugated. Besides, CBD-M solution was stable for 6 months at 4°C and room temperature. In vitro
antioxidant studies found that the antioxidant activity of CBD remained at the same level after micellization.

Conclusion:

These results suggest that CBD-M may be a promising and competitive formulation for the
delivery of CBD, laying a foundation for improving the bioavailability in the future.
Magnetic Nanoparticles for Nucleic Acid Delivery: Magnetofection, Gene Therapy and Vaccines
Authors: Tuttolomondo M.V.
Published: March 2023

Gene therapy offers an alternative for the treatment of diseases such as cancer or neurodegenerative diseases by replacing, introducing or inactivating genes in the patient. In this aspect, the use of nanoparticles as nucleic acid delivery systems that prevents its degradation and facilitates its incorporation into target cells has been a subject of intense study in recent years. Among them, magnetic nanoparticles (MNP) offer advantages as new alternatives for non-viral transfection, such as guiding the nanoparticle and its content through magnetic fields towards target organs, increasing the efficiency and reducing transfection times. The use of MNP carrying genetic information to achieve transfection by the application of magnetic fields is known as magnetofection. In most cases, superparamagnetic iron oxide nanoparticles (SPIONs) are used as vehicles which also contain a cationic organic coating to increase their stability, gene incorporation and interaction with cell membranes. Another field in which the application of these new technologies is gaining attention is in the development of DNA and RNA- based vaccines for immunization and immunotherapy. In the following chapter, the use of magnetofection for in vitro experiments as well as the study of in vivo vaccine assays or gene therapy using MNP as nucleic acid carriers, will be discussed.
Las Epistemologías del Sur para una educación emancipadora
Authors: Estrada García Alex
Published: March 2023

El artículo desarrolla una argumentación sobre las Epistemologías del Sur de Boaventura de Sousa Santos como un medio para emancipar la educación escolarizada. El análisis se enmarca en la sociología de la educación, desde donde nace un diálogo epistemológico sobre las posibilidades para reinventar los procesos de formación educativa, tomando en cuenta las transformaciones continuas de las sociedades y la eclosión de paradigmas, teorías, enfoques en la educación. Se profundiza en una crítica a las epistemologías que han gobernado con certeza los currículos educativos, eliminado los saberes considerados como no científicos, o sea aquellos que no son cuantificables ni medibles para el método científico. En conclusión, para una emancipación de la educación debe reestructurarse los procesos de enseñanza y aprendizaje, es decir, se sugiere repensar dichos procesos y orientarles hacia una educación para la vida con un sentido global y que transcienda los saberes especializados: una educación transdisciplinar.
Acceptance and Privacy Perceptions Toward Video-based Active and Assisted Living Technologies: Scoping Review
Authors: Mujirishvili Tamara , Maidhof Caterina , Florez-Revuelta Francisco , Ziefle Martina , Richart-Martinez Miguel , Cabrero-García Julio
Published: March 2023

Background

The aging society posits new socioeconomic challenges to which a potential solution is active and assisted living (AAL) technologies. Visual-based sensing systems are technologically among the most advantageous forms of AAL technologies in providing health and social care; however, they come at the risk of violating rights to privacy. With the immersion of video-based technologies, privacy-preserving smart solutions are being developed; however, the user acceptance research about these developments is not yet being systematized.

Objective

With this scoping review, we aimed to gain an overview of existing studies examining the viewpoints of older adults and/or their caregivers on technology acceptance and privacy perceptions, specifically toward video-based AAL technology.

Methods

A total of 22 studies were identified with a primary focus on user acceptance and privacy attitudes during a literature search of major databases. Methodological quality assessment and thematic analysis of the selected studies were executed and principal findings are summarized. The PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines were followed at every step of this scoping review.

Results

Acceptance attitudes toward video-based AAL technologies are rather conditional, and are summarized into five main themes seen from the two end-user perspectives: caregiver and care receiver. With privacy being a major barrier to video-based AAL technologies, security and medical safety were identified as the major benefits across the studies.

Conclusions

This review reveals a very low methodological quality of the empirical studies assessing user acceptance of video-based AAL technologies. We propose that more specific and more end user– and real life–targeting research is needed to assess the acceptance of proposed solutions.
A Continuous Aerobic Resistance Exercise Protocol for Concussion Rehabilitation Delivered Remotely via a Mobile App: Feasibility Study
Authors: Hutchison Michael G , Di Battista Alex P , Loenhart Matthew M
Published: March 2023

Background

In recent years, several studies have consistently reported the beneficial effects of aerobic exercise in alleviating symptoms following concussion. However, exercise modality recommendations by practitioners are often limited to traditional exercise equipment (eg, treadmills and stationary bikes). Advances in digital technologies may help to overcome this limitation, as mobile apps can now provide users with high-quality instructional videos, programs, and monitoring capabilities using alternative modalities such as resistance exercises. Mobile technologies are also rapidly expanding to deliver and complement in-person clinical care. Thus, it is imperative to evaluate this emerging technology on its feasibility, safety, and clinical utility for concussion care.

Objective

The objective of the study was to determine the feasibility of a mobile app to deliver a resistance exercise protocol with minimal equipment to individuals following concussion. Feasibility was defined by retention, adverse events, and achievement of a target heart rate (HR) of 60%±5% (age-adjusted percentage of max: 220 – age). HR data were collected using an Apple Watch, Series 6. Symptoms were evaluated before and after 3 exercise sessions.

Methods

A 2-week, prospective, single-arm pilot study was conducted on 21 adults diagnosed with a concussion. Users were provided a continuous aerobic resistance exercise (CARE) protocol through a mobile app.

Results

A total of 18 participants (14 female and 4 male) completed a 3-session exercise plan. The median age-adjusted percent of HR max for session 1 was 55.5% (IQR 49%-63%), 58.1% (IQR 50.8%-65.2%) for session 2, and 57.4% (IQR 49.5%-64.7%) for session 3. Individual median HR% across all sessions ranged from 46.9% to 67.4%; furthermore, 10 participants (55.5%) had a total mean HR% within the target HR%, 7 participants had a mean HR% below 55%, and 1 participant had a mean HR% above 65%. In addition, adherence to the plan resulted in a decrease in reported symptom burden with 94% posterior probability.

Conclusions

Following concussion, a CARE protocol delivered through a mobile app resulted in no adverse effects with 14% (n=3/21) attrition over 3 sessions. CARE was successful in achieving an aerobic exercise intensity of 55%-65% of age-adjusted maximum HR in the majority of participants and resulted in a decrease in reported symptom burden. The potential for this platform in concussion rehabilitation warrants further investigation. Future studies are needed to assess the use of this technology throughout concussion recovery in both individuals with acute concussion, and those with persistent symptoms.
Implementation of Lean Construction to Eliminate Waste: A Case Study Construction Project in Indonesia
Authors: Anggraini Wresni , Harpito  , Siska Merry , Novitri Dian
Published: March 2023

Lean Construction (LC) presented innovative practices to maximize the production value and minimize the production waste during construction. The problem that frequently occurs in the project is delaying the schedule, leading to time and cost overrun. This research aims to eliminate waste that causes delay and inefficiency. Several LC techniques were carried out to improve the efficiency of this project, namely: Value Stream Mapping (VSM) to discover wastes and determine Process Efficiency Cycle (PCE); Waste Assessment Model (WAM) to identify the inter-relationship among wastes; Fishbone (Ishikawa) diagram analysis to get the root cause of the waste.   Research results showed the three highest wastes: defect 14.06%, over production 21.44%, and the highest rank was unnecessary inventories 31.73%. After implementing LC techniques, the PCE increased from 72 % to 79%. The implication of this research is to provide recommendations to the project’s stakeholders in running the building construction to avoid delay and inefficiency.
Cognitive Behavioral Therapy untuk menurunkan perilaku menyakiti diri pada individu dengan Borderline Personality Disorder
Authors: Amelia Risa Nur
Published: March 2023

Borderline Personality Disorder (BPD) is a personality disorder that appears in adolescence or early adulthood. The purpose of this study was to determine the role of cognitive behavioral therapy (CBT in reducing self-harm behavior in individuals with BPD. The subject of this study was a 24-year-old female university student who had BPD symptpamans such as irritability, difﬁculty controlling emotions, self-harm, and frequent suicide attempts. The assessment methods used were psychological interviews, observations, graphic tests, SSCT tests, WHODAS self-reports, and self-harm inventories. The results of the study show that CBT can effectively reduce self-harm behavior in individuals with BPD.
Keywords: Boarderline personality disorder, cognitive behavioral therapy, self-harm
 
Abstrak
Borderline Personality Disorder (BPD) adalah gangguan kepribadian yang muncul pada masa remaja atau dewasa awal. Tujuan dari penelitian ini adalah untuk mengetahui peran terapi perilaku kognitif dalam mengurangi perilaku menyakiti diri sendiri pada individu dengan BPD. Subjek penelitian ini adalah seorang mahasiswi berusia 24 tahun yang memiliki gejala BPD seperti mudah marah, mudah marah, kesulitan mengendalikan emosi, menyakiti diri sendiri, dan sering mencoba bunuh diri. Metode asesmen yang digunakan adalah wawancara psikologis, observasi, tes grafis, SSCT, laporan diri WHODAS, dan inventarisasi menyakiti diri sendiri. Hasil penelitian menunjukkan bahwa terapi perilaku kognitif dapat mengurangi perilaku menyakiti diri sendiri pada individu dengan BPD.
Kata kunci: Boarderline personality disorder, terapi perilaku kognitif, menyakiti diri sendiri
Practical randomness amplification and privatisation with implementations on quantum computers
Authors: Foreman Cameron , Wright Sherilyn , Edgington Alec , Berta Mario , Curchod Florian J.
Published: March 2023

We present an end-to-end and practical randomness amplification and privatisation protocol based on Bell tests. This allows the building of device-independent random number generators which output (near-)perfectly unbiased and private numbers, even if using an uncharacterised quantum device potentially built by an adversary. Our generation rates are linear in the repetition rate of the quantum device and the classical randomness post-processing has quasi-linear complexity – making it efficient on a standard personal laptop. The statistical analysis is also tailored for real-world quantum devices.
Our protocol is then showcased on several different quantum computers. Although not purposely built for the task, we show that quantum computers can run faithful Bell tests by adding minimal assumptions. In this semi-device-independent manner, our protocol generates (near-)perfectly unbiased and private random numbers on today's quantum computers.
Modified Bernstein-Kantorovich operators reproducing affine functions
Authors: Zhang Bin , Yu Dansheng , Wang Fengfeng
Published: March 2023

In the present paper, we introduce a new variant of Bernstein-Kantorovich
operators which reproduce affine functions. The approximation rate of the
new operators for continuous functions and Voronovskaja?s asymptotic
estimate are obtained.
Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq
Authors: Hussain Huda A. Kareem , Muftin Najlaa Qassim , Al-jibouri Mahmoud Najim , Ben Salah Gada
Published: March 2023

The most prevalent form of heart disease and the main cause of death in both developed and developing nations is CAD. It happens when "plaque," or cholesterol or other fatty deposits that accumulate on the inner wall of the artery, narrows or blocks the arteries that deliver blood to the heart. Over time, chest pain might develop as a result of the reduction in blood flow to the heart caused by this plaque accumulation. The study was designed to find if Arginase acts as a biomarker for diagnosing Coronary Artery Disease (CAD). A total of 90 individual samples were included in the present study, the control group consist of 40 healthy individual samples, while the CAD patients were 50 individual samples. Some biochemical parameters such as fasting blood glucose (FBG), troponin I(TnI), high sensitivity C-reactive protein (hs-CRP), lipid profile, lactate dehydrogenase (LDH), and Arginase activity were analyzed. The results of the current study showed no significant differences in the average age of patients (67.00±6.78) when compared with the control group (61.10±6.46), P>0.05. A significant increase Was found in the FBI level, cholesterol, triglycerides, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), TnI, hs-CRP, LDH, and Arginase activity in the patient's group when compared with the control group. While significant decrease (P<0.05) was revealed in the high-density lipoprotein (HDL) level in CAD patients in comparison to the control group. Also, there was a positive significant correlation between Arginase activity with each age and FBG. As for the ROC operator curve for Arginase, it was found that the area under the curve (AUC) was 0.953 with a sensitivity of 90%, and specificity of 95%. The results in the present study indicate a possible use of Arginase as a diagnostic marker for CAD.
”Hun er jo mit barn, men det er deres sted” – Forældre og pædagogers grænsesøgning i hverdagens samarbejde
Authors: Juhl Pernille , Westerling Allan , Dannesboe Karen Ida
Published: March 2023

I denne artikel viser vi, hvordan det daglige samarbejde mellem pædagogisk personale og forældre præges af stigende institutionalisering af forældreansvar, og af at arbejdsdelingen mellem daginstitution og familie ændrer sig. Artiklens analyser bygger på empirisk materiale fra to forskningsprojekter i danske daginstitutioner. Projekterne har haft henholdsvis pædagogers og forældres perspektiver på samarbejdet om børns tidlige læring i fokus. I denne artikel sætter vi primært fokus på forældrenes perspektiver og inddrager kun i mindre omfang pædagogernes perspektiver. Teoretisk tager vi afsæt i en forståelse af familien som social praksis forbundet til andre praksisser og i forlængelse heraf en forståelse af forældreskab som et fænomen, der udspiller sig i og formes i mødet med omsorgsgivere andre steder – fx i daginstitutionen. Analytisk bruger vi begrebet grænsesøgning til at sætte fokus på, hvad forældre og pædagoger hver især gør for at håndtere samarbejdet mellem familie og daginstitution i hverdagens møder, og hvordan arbejds- og ansvarsfordeling forhandles.
English abstract
“She’s my child, but it’s their place” – Boundary work in everyday life
In this article, we show how the daily collaboration between pedagogues and parents is characterised by increasing institutionalisation of parental responsibility, and that the boundaries between day care institution and family have changed. The analyses in this article are based on empirical data derived from two research projects in Danish day care institutions. Theoretically, we take as our starting point an understanding of the family as social practice connected to other practices, and in an understanding of parenthood as a phenomenon that is shaped and developed in the daily encounters with caregivers elsewhere – e.g., in the day care institution. Analytically, we use the concept of boundary work to focus on what parents and pedagogues do to deal with collaboration between family and day care in everyday encounters, and how the division of labour and responsibilities is negotiated.
Luftmakt i Arktis
Authors: Tørrisplass Ole Marius
Published: March 2023

This chapter asks what role air power plays in the Arctic and discusses how air power can contribute to create effects in the region in times of peace, crisis and war. The chapter concludes that air power is a central element in the military strategies of Russia, NATO and Norway, and that all the actors use air power capabilities to maintain situational awareness and presence, enforce national jurisdiction and interests, and to send political messages. Russia has invested in a range of new capabilities, in particular air-defence systems and long-range precision weapons, that improve the ability to secure key areas and provide significant offensive combat power, thereby contributing to offset some of NATO’s conventional advantage. Some NATO members, most importantly the United States, have turned their attention towards the Arctic and have published new strategies specific to the region that highlight the role of air power in securing access and freedom to manoeuvre in crisis and war. Allied air power capabilities also operate in the region regularly. Norway has a small but capable inventory of air power capabilities that is centred around the new F-35 Lightning II fighter aircraft and P-8 Poseidon maritime patrol aircraft. The main task of the Norwegian Air Force is to fight for control of the air and support land and maritime operations, both as a first responder in preparation for NATO involvement and as an integrated force with the alliance. The flexibility and offensive punch of the of the F-35 create new opportunities that may in turn require a critical revision of traditional Norwegian concepts and strategies for the use of air power.
Masterforum som arena for veiledning og profesjonsfaglig samarbeid – erfaringer fra SUKIP
Authors: Ohna Stein Erik , Moen Vegard
Published: March 2023

This chapter describe how the SUKIP-project has involved master’s students in the research. It explains how the students have gained access to SUKIP-data from kindergarten and school and how guidance and collaboration between the students and researchers is organized within a monthly master forum. Two questions are elucidated in the chapter: What is the focus of the master’s theses and how do they reflect the purpose of SUKIP? What are the students’ experiences from participating in the master’s forum? Although inclusion has been a fundamental principle in Norwegian education policy for several decades, research that focuses on teacher training for inclusion has not received the same attention. The chapter therefore seeks to contribute to the development of knowledge about teacher education for inclusion.
Constraints Facing African Academic Libraries in Applying Electronic Security Systems to Protect Library Materials
Authors: Kotoroi Gladness
Published: March 2023

This article reviews published literature to identify factors that impede the application of electronic security systems (ESSs) in protecting library materials in African academic libraries. The information for the study was gathered through a review of online literature from databases, namely ProQuest, EBSCO, Emerald, Library Literature, Research Gate Information, and Google search engine. The scope of the literature covered the time when African academic libraries began to use ESSs to protect their collections to the present. It covered only literature that addresses the challenges that hinder African academic libraries from utilizing ESSs to protect library materials. Information was collected by reading the abstracts and conclusion of the online documents. In the beginning, a total of 91 articles were collected as a population of the study. However, only fifty-four (54) articles were found to be relevant to the area of the study. Basic keywords and advanced searching, namely truncations, headings, Boolean operators, electronic security systems, academic libraries, security, African Libraries, theft and mutilation were also used to get relevant literature on the topic from peer-reviewed and scholarly resources.  Based on the findings of the reviewed literatures it is concluded that African academic libraries undergo nearly the same challenges where most of which can be addressed because they are generated by the managements, library staff and the environment in which the libraries operate rather than the ESSs. The researcher recommends that African academic library managements should cope with the technological changes so as to compete with the market demand. With that regard, the reported ESSs challenges facing  African academic libraries should be aggressively addressed in order to make the application of ESSs effective. Equally, another study should be carried out to inform about the ramifications of not addressing electronic security systems.
A Meta-Analysis Study: The Effect of Problem Based Learning Integrated with STEM on Learning Outcomes
Authors: Suciana Dola , Hartinawati  , Sausan Inas , Meliza
Published: March 2023

The purpose of this study was to determine the effect of problem-based learning integrated with STEM on learning outcome. In this study, reanalysis of the data from previous studies regarding the effect of the problem-based learning integrated with STEM on learning outcomes. This research used a systematic review method with quantitative techniques (meta-analysis). The results of previous studies related to the effect of the PBL integrated with STEM on learning outcomes that have been published in a journal were analyzed using meta-analysis techniques. The data were collected using an instrument in the form of a meta-analysis coding sheet. There are 21 articles analyzed. The technique used is to measure the value of the effect size from experimental results in these scientific articles. Based on the research that has been done, it is known that the PBL integrated with STEM has an effect on improving learning outcomes. This can be seen from the average effect size value of 1.28 with a high effect category. In addition, from the acquisition of this effect size value, it is known that PBL with STEM also has an effect on improving learning outcomes in terms of education levels (elementary school, junior high school, senior high school or college levels) and subjects (mathematics, chemistry, physics biology, science for elementary and junior high school). Based on this research, it can be concluded that the PBL integrated with STEM has an effect on improving student learning outcomes at various levels of education and various subjects.
PREDIÇÃO DE SUICÍDIO ENTRE ADOLESCENTES A PARTIR DA ÚLTIMA DÉCADA PRÉ-PANDÊMICA EM MATO GROSSO
Authors: Martins Paola Braz , Azevedo Jhonatan Tyson Barros , Riegel Fernando , Lourenção Luciano Garcia , Da Silva Tarciso Feijó , Nodari Poliana Roma Greve , Da Silva Liliane Santos , Lemes Alisséia Guimarães , Terças-Trettel Ana Cláudia Pereira , Do Nascimento Vagner Ferreira
Published: March 2023

Objetivo: analisar a predição de suicídios entre adolescentes a partir da última década pré-pandêmica em Mato Grosso. Método: trata-se de estudo ecológico e retrospectivo. A coleta de dados ocorreu em janeiro de 2021, referente ao recorte temporal de 2009 a 2019. Utilizou-se dados secundários do Sistema de Informação sobre Mortalidade via Secretaria Estadual de Saúde de Mato Grosso. Para análise dos dados, utilizou-se o programa STATA 14.0. Resultados: a predição de suicídios entre os adolescentes de Mato Grosso revelou predominância do sexo masculino, cor não branca e com oito anos ou mais de escolaridade. Os suicídios em Mato Grosso apresentam estabilidade em relação ao sexo. Quanto a cor, o Centro-Oeste possui maior disparidade quando comparado ao Mato Grosso. Todavia, ambos exibem comportamentos epidemiológicos semelhantes na escolaridade. Conclusão: a partir da última década pré-pandêmica, previu o crescimento de casos de suicídios entre adolescentes em Mato Grosso, e que não se assemelha à totalidade do perfil esperado para a região Centro-Oeste.
Comportamento suicida: conhecer para prevenir. Dirigido para profissionais da imprensa
Authors: Associação Brasileira de Psiquiatria
Published: March 2023

A Associação Brasileira de Psiquiatria – ABP disponibiliza a cartilha de orientações “Comportamento Suicida: Conhecer para Prevenir” para profissionais de imprensa. O papel da imprensa é fundamental nesse mutirão em defesa da vida. Nos últimos anos,matérias que orientaram a população sobre doenças mentais contribuíram com a campanha de prevenção no suicídio, já que aproximadamente 100% dos casos de suicídio registrados estão associados com histórico de doença mental. A informação corretadirecionada à população é muito importante para orientar e prevenir o suicídio. Por isso, lançamos esta edição atualizada da cartilha “Comportamento Suicida: Conhecer para Prevenir”, para contribuir com o trabalho dos jornalistas com números atualizados e revistos sobre suicídio no Brasil e no mundo, com base em dados da Organização Mundial da Saúde (OMS) e do Ministério da Saúde. Nos últimos oito anos, realizamos muitas ações que complementam esse trabalho. Em 2014, lançamos, em parceria com o Conselho Federal de Medicina (CFM), a cartilha “Suicídio Informando para Prevenir”, que é voltada aos profissionais da área de saúde, para orientá-los sobre ideação suicida, fatores de risco, avaliação, abordagem, atendimento etratamento dos pacientes com risco de suicidio. A cartilha foi um grande sucesso e está disponível em pdf no site da campanha.A ABP também trouxe para o Brasil a campanha internacional Setembro Amarelo, que tem como objetivo a prevenção do suicídio, unindo forças durante todo o mês, o dia 10 de setembro é, oficialmente, o Dia Mundial de Prevenção ao Suicídio. Orientamos sobre as doenças mentais, divulgamos mensagens de apoio e realizamos atividades científicas e culturais que atendam a população. Essa é uma das nossas missões, obrigada por fazer parte dela. A vida é a melhor escolha!
Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet
Authors: Nabila Inasa , Thadeus Maria Selvester , Herardi Ryan
Published: March 2023

This study aims to determine the effectiveness of parijoto fruit extract (Medinilla speciosa Blume) in improving the condition of fatty liver in male balb/c mice (Mus musculus L.) fed with a high-fat diet. Thirty male balb/c mice weighing 20 to 30 g were randomly divided into six groups, i.e: 1) Standard feed and Carboxymethyl Cellulose Sodium or CMC-Na 0.5% (K1); 2) High-fat diet and CMC-Na 0.5% (K2); 3) High-fat diet and simvastatin 0.026 mg/day (K3); 4) High-fat diet and parijoto fruit extract 5.6 mg/20 g BW (P1); 5) High-fat diet and parijoto fruit extract 8.4 mg/20 g BW (P2); 6) High-fat diet and parijoto fruit extract 11.2 mg/20 g BW (P3). Standard feed, high-fat diet, simvastatin, and parijoto fruit extract were administered for 56 days. On the 57th day, the total of 30 mice were terminated and the livers were then removed for H&E staining histopathological slides. Data on the degree of fatty liver on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Medinilla speciosa Blume extract at a dose of 5.6 mg/20 g BW in group P1 prevent the steatosis degree compared to high-fat feed mice in group K2 (p>0.05). Parijoto fruit extract could act as the potential treatment for fatty liver.
Plant-Based Diet during the Prepubertal Period and Age at Menarche: A Systematic Review
Authors: Christanti Stefani , Syafiq Ahmad
Published: March 2023

This systematic review aimed to analyze the effect of a prepubertal plant-based diet, through dietary patterns and its nutritional components, on the age at menarche. Systematic searches through Medline (EBSCO), Embase, Health & Medical Collection (Proquest), Scopus, and Google Scholar for articles published between January 2000 and September 2022 in English using the keywords of plant-based diet, age at menarche, and their synonyms identified 673 articles. Articles were screened through titles and abstracts, as well as full-text reviews based on inclusion/exclusion criteria and assessment of research quality using the JBI Critical Appraisal Tools with a JBI cut-off final score of >50%, leaving 12 articles in this systematic review presented in the PRISMA 2020 flowchart. Data analysis was conducted descriptively by comparing findings between articles. Age at menarche/puberty was reported as an outcome of food intake through a vegetarian diet, Mediterranean diet, vegetable protein, phytoestrogens and isoflavones, and dietary fiber. Based on the analysis of each subgroup, the plant-based diet did not consistently influence the incidence of menarche. In conclusion, a plant-based diet does not significantly affect age at menarche when it is accompanied by a balanced intake of energy and macro-micronutrients. The principles of balanced nutrition and the assistance of nutritionists are needed in practicing a plant-based lifestyle, especially for children and adolescents who are still in the developmental stage.
ORF8 Breaks Genetic System of Macrophage to Escape Reproductive Immunity by Telomerase and NOS-Like System
Authors: liu wenzhong , Li hualan
Published: March 2023

There is evidence that SARS-CoV-2 ORF8 may block interferon, change endoplasmic reticulum stress, damage chromatin, cause apoptosis, and hurt the male reproductive system through nitric oxide (NO). The pathogenesis of COVID-19 will be easier to understand if we know what ORF8 does. In this study, the bioinformatics technique of domain searching was used to find out what the ORF8 protein does in the body. ORF8 has domains associated with EF-hand, oxidized low-density lipoprotein cholesterol binding, macrophage-specific clearance receptors, suppression of telomerase transcription, damaged telomeres of  DNA, Cyclin, NOS, ubiquitination, etc., according to the search results. ORF8 binds to oxidized VLDL cholesterol via macrophage-like specialized clearance receptors (SMB and SRCR)  domains and is endocytosed into macrophages in the form of CD14+ receptor-bound VLDL, as revealed by the results. ORF8 colonizes macrophages via domain-like ABC and MlaD functions. ORF8 reaches the nucleus via cholesterol nuclear translocation and binds histones by ubiquitination. Ca2+ binding activates ORF8 NOS activity to produce NO, influencing histone acetylation, and ORF8 binds the CpG island of the telomerase reverse transcriptase gene in order to suppress transcription. ORF8 also binds to DNA telomeres via the TRF domain and telomerase-like activity, catalyzes telomere breaking via ribonuclease II, DNA topoisomerase (TOPEUc), and the Ku protein. And ORF8 activates the S/G2 switch via the cyclin and motor domains. ORF8 interferes with the genetic activity of macrophages and induces the death of immune cells, hence subverting the NO regulating mechanism of the immune system and facilitating virus evasion from the reproductive immune system. We suggested that ORF8 may be the virus's self-destruction mechanisms, which accelerate the death of infected cells owing to chromatin damage and indirectly lead to the demise of the virus when the synthesis of ORF8 being greater than the secretion.
Electrostatic tuning of transmission in NbS2/WSe2 Lateral Hetero-Structures: A computational study
Authors: Kumari Poonam , Golsanamlou Zahra , Smogunov Alexander , Sementa Luca , Fortunelli Alessandro
Published: March 2023

We present a first-principles computational study of the NbS2/WSe2 junction between two transition metal dichalcogenide monolayers as a prototypical metal/semiconductor 2-dimensional (2D) lateral hetero-structure (LH) to investigate the effects of electrostatic perturbations on electron transport in 2D LH systems. In order to simulate electrostatic (charged or dipolar) defects in the substrate, we introduce ionic systems (LiF lines) properly positioned in two different configurations and study cases, corresponding to modeling two different phenomena: (i) an electrostatic defect in the middle of the semiconducting part of the hetero-structure (found to be qualitatively analogous to a gate voltage opposing transmission), and (ii) an electrostatic perturbation re-aligning and flattening the electrostatic potential along the asymmetric LH junction. In the former case, we determine a substantial decrease of transmission even for small values of the perturbation (providing information that can be used to achieve a quantitative correlation between substrate-induced defectivity and device performance degradation in experiment), whereas in the latter we predict that electron transport can be ideally significantly enhanced by properly tuning external electrostatic perturbations at the interface.