bluuebunny/crossref_metadata_2025 huggingface dataset:
Jean Eïd (1819–1878): From Levantine Dragoman to Godfather of a Belgian-Egyptian Dynasty
Authors: Huskens Gert
Published: March 2023

As a young, but ambitious state that aspired to acquire a respected position in the nineteenth-century European concert, one of the institutions Belgium relied on was its diplomatic corps. Whereas the capitals of Europe quickly became the new home of career diplomats, Belgium gradually developed a consular apparatus that was staffed by locally recruited agents in more faraway areas. In the Eastern Mediterranean, the position of dragoman, who served as translator to the diplomatic representatives, was especially relevant in a setting where language barriers hindered the expansion of Belgium’s diplomatic and commercial interests. This essay unravels the history of the Belgian dragomanate in Egypt and focusses on one dragoman in particular: Jean Eïd. Addressing his term in Belgian service from the perspective of subalternity, I will demonstrate how the social, professional and legal status of these actors who roamed the increasingly entangled Levantine sphere in this period, is particularly challenging to grasp, while also recognizing the potential his position had for the next generations that succeeded him.
Wood and bark anatomy of the charismatic Wisteria vines (Leguminosae)
Authors: Nejapa Rosa , Pace Marcelo R.
Published: March 2023

Wisteria is a legume genus composed of lianas with a disjunct distribution, occurring in temperate zones of eastern Asia and the eastern United States, being also introduced in numerous countries as an ornamental. The anatomy of the wood has been previously studied for W. sinensis and only some characteristics of the phloem have been reported for this species. Here we describe the overall wood and bark anatomy of four Wisteria species and identify diagnostic, informative anatomical features to sort them for identification purposes among the species of the genus. Samples were collected from natural, naturalized, and introduced populations and processed using traditional anatomical techniques, while a few samples were analyzed from photos available online. Wisteria species show conserved wood anatomy, even if species occur as far apart as Asia and North America. The presence of a cambial variant, vessel dimorphism, G-fibers, non-lignified axial, and ray parenchyma is common and is here interpreted as part of the lianescent syndrome. The subepidermal origin of the periderm is taxonomically informative within the subfamily. The few variable features that vary among species are the arrangement of narrow vessels: radial to dendritic pattern in the specie W. frutescens and arranged in clusters in the species distributed in Eastern Asia. Also, the ray cell composition: procumbent, square, and upright cells mixed through the body in the specie W. sinensis and procumbent to square cells in the body and upright in the margins in the species W. brachybotrys and W. frutescens.
Why Is the ‘Timaeus’ So Important for Middle Platonists (Again)? A New Proposal
Authors: Piazzalunga Arianna , Petrucci Federico Maria
Published: March 2023

This paper aims to show that the Middle Platonists’ appeal to the Timaeus was grounded in a complex and effective philosophical reasoning: the Middle Platonists conceived of Plato’s text as a web of passages which Plato himself had carefully established. Only a few of them were granted a qualified priority, namely, those offering a complete and comprehensive philosophical account of the key elements which the Platonists regarded as fundamental. This will allow us to show that the Middle Platonists’ preference for the Timaeus does not depend on the fact that it is systematic. Rather it is systematic insofar as it proves capable of giving context to passages from other dialogues and provides them with an account that is philosophically sound.
Plato’s Republic 515a5: Prisoners ‘Like Us’
Authors: Gkatzaras Thanassis
Published: March 2023

This paper questions the traditional interpretation of Plato’s Republic 515a5. When Socrates claims that the prisoners in the simile of the Cave are ‘like us’, he does not imply any sort of similarity or analogy between their cognitive state and ours. Rather, I argue he says that we should imagine a cave inhabited by ordinary human beings, instead of some fictitious creatures. Among other things, Plato’s intent is to highlight the weakness of our human nature in both parts of the simile. Consequently, concerning someone’s chance to become true philosopher, Plato’s view is quite pessimistic.
Not-Being, Contradiction and Difference. Simplicius vs. Alexander of Aphrodisias on Plato’s Conception of Not-Being
Authors: Granieri Roberto
Published: March 2023

In explicating a passage from Physics A 3, Simplicius reports a criticism by Alexander of Aphrodisias against Plato’s conception of not-being in the Sophist. Alexander deems this conception contradictory, because it posits that unqualified not-being is. Simplicius defends Plato and gives a diagnosis of what he regards as Alexander’s interpretative mistake in raising his objection. I unpack this debate and bring out ways in which it sheds light on important aspects of Plato’s project in the Sophist and of Simplicius’ own philosophical background, notably in Damascius’ De principiis.
The Fourth World Congress of Taiwan Studies: ‘Taiwan in the Making’, University of Washington, Seattle, 27–29 June 2022
Authors: Lee Chun-yi , Zani Beatrice
Published: March 2023

This report highlights and offers reflections on three unique features of the fourth World Congress of Taiwan Studies (wcts4) held in Seattle in June 2022. First, following the covid-19 pandemic, wcts4 was one of the first large-scale conferences in the field of Taiwan studies to be held in hybrid mode. Second, although three previous editions have taken place since 2012, wcts4 was the first to be held in the United States. Third, it is the first Congress to launch a major new publication, the forthcoming Encyclopedia of Taiwan Studies. Most media coverage of wcts4 has emphasised only that it was held in the United States. This report goes further, focusing on why it was held in the US, and why Seattle in particular, and on the Congress’s importance more generally to the global field of Taiwan studies.
Nomenclatural review and history of Pycnoporus (Polyporaceae): A widespread, bright-reddish genus in Basidiomycota
Authors: ARAÚJO F. GURGEL RAFAELA , S. CARVALHO CATARINA , K. ISHIKAWA NOEMIA , CABRAL TIARA S.
Published: March 2023

N/A
Epibiotic association of encrusting cheilostome bryozoans on shells of an invasive mussel from rocky shores of South Africa, with the description of a new aviculiferous species of Chaperia
Authors: BOONZAAIER-DAVIDS MELISSA K. , MA KEVIN C. K. , MCQUAID CHRISTOPHER D.
Published: March 2023

Rocky shores typically exhibit a variety of sedentary and free-moving forms of epibionts associated with the shells of mussel basibionts. This paper provides a first report on epibiotic bryozoans found on shells of the invasive Mediterranean mussel, Mytilus galloprovincialis Lamarck. More than 2500 mussels were collected between December 2019 and October 2020 from rocky shores during low spring tides across the south–southeast coast of South Africa. Ten percent of these mussels hosted epibiotic bryozoans. We examined a subset of these epibiotised mussels to assess the diversity of bryozoans. Three encrusting cheilostome species were identified: Chaperia atypica n. sp., Celleporella hyalina (Linnaeus), and Hippomonavella sp. This new species is the first Chaperia with avicularia and the first South African species with ooecia. This study highlights the biological diversity of epibiotic bryozoans on mussel shells and, given their differences in microtopography, the possibility that invasive species can provide a new substratum for rare, overlooked or undescribed species of epibionts.
Three new species of the genus Synagelides Strand, 1906 (Araneae, Salticidae) from Yunnan, China
Authors: LI BING , CHENG YI , WANG QI , YANG SUFANG , PENG XIANJIN
Published: March 2023

Three new species of Synagelides Strand, 1906 (Araneae, Salticidae) from Yunnan, China are described: S. furcatoides sp. nov. (♂♀), S. furcatus sp. nov. (♂) and S. montiformis sp. nov. (♂♀). Photographs of the habitus and copulatory organs as well as a distribution map are provided.
A proposal to synonymize Loffienema with Haematozoon, Quercorhabditis with Diploscapteroides, and Stegorhabditis with Stomachorhabditis (Nematoda, Rhabditida, Rhabditomorpha), including keys to species identification
Authors: ABOLAFIA JOAQUÍN
Published: March 2023

The morphology of three genera of the family Rhabditidae, Loffienema, Quercorhabditis and Stegorhabditis, described recently from Jammu and Kashmir (India), is analyzed in detail. After the revision of their morphology, these genera are proposed to be synonymized with other three known genera: Loffienema with Haematozoon, Quercorhabditis with Diploscapteroides, and Stegorhabditis with Stomachorhabditis. In addition, the taxonomic status of the genus Distorhabditis is discussed. Dichotomous keys for the identification of species of the genera Haematozoon, Diploscapteroides and Stomachorhabditis are included.
Healing Efficacy of Hesperetin-Containing Chitosan Gel in Burn Wound: Formulation Design and In Vivo Evaluation
Authors: Alsareii Saeed Ali , Ahmad Javed , Umar Ahmad , Ahmad Mohammad Zaki , Mohammed Abdul Aleem , Manaa Alamri Abdulrahman , AlAsmari Mansour Yousef , Elbashir Abdulhadi Mohamed
Published: March 2023

More than 5 million people require medical attention due to burn-related injuries annually. Significant research has been carried out in recent decades to develop approaches to improve the healing of burn wounds. The focus has also been on the development of natural product-based therapeutic
remedies for the treatment of burn wounds. This has been done primarily due to multimodal mechanisms exhibited by some promising bioactive molecules of natural origin. Hesperetin is one such molecule that possesses strong anti-inflammatory and antioxidant properties. It is mainly obtained
from citrus species. The goal of the current study was to assess how well chitosan gel that contains hesperetin may cure burn wounds. The advantage of using chitosan gel is that it could form a depot at the site and provide a protective therapeutic covering over burn wounds. In the present
study, hesperetin-containing chitosan gel was prepared and evaluated for percentage hesperetin content, extrudability, spreadability, and rheological behavior. The preclinical wound healing activity was evaluated using an experimental burn wound model in Wistar rats. The results of the animal
experiment showed early and better healing of burn wounds in animals treated with hesperetin-containing chitosan gel. There was 92.79% healing after 14 days of application of hesperetin-containing chitosan gel compared to 69.49% healing observed in the control group. Further, the histopathological
evaluation suggested no inflammatory cell infiltration, normal epidermal growth, and normal collagen bundle arrangement in these animals. Overall the results provide proof of concept to establish the wound healing potential of hesperetin-containing chitosan gel against burn wounds.
Recent Impact of COSMIC-2 with Improved Radio Occultation Data Assimilation Algorithms
Authors: Cucurull Lidia
Published: March 2023

A Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) follow-on constellation, COSMIC-2, was successfully launched into equatorial orbit on 24 June 2019. With an increased signal-to-noise ratio due to improved receivers and digital beam-steering antennas, COSMIC-2 is producing about 5000 high-quality radio occultation (RO) profiles daily over the tropics and subtropics. The initial evaluation of the impact of assimilating COSMIC-2 into NOAA’s Global Forecast System (GFS) showed mixed results, and adjustments to quality control procedures and observation error characteristics had to be made prior to the assimilation of this dataset in the operational configuration in May 2020. Additional changes in the GFS that followed this initial operational implementation resulted in a larger percentage of rejection (∼90%) of all RO observations, including COSMIC-2, in the mid- to lower troposphere. Since then, two software upgrades directly related to the assimilation of RO bending angle observations were developed. These improvements were aimed at optimizing the utilization of COSMIC-2 and other RO observations to improve global weather analyses and forecasts. The first upgrade was implemented operationally in September 2021 and the second one in November 2022. This study describes both RO software upgrades and evaluates the impact of COSMIC-2 with this most recently improved configuration. Specifically, we show that the assimilation of COSMIC-2 observations has a significant impact in improving temperature and winds in the tropics, though benefits also extend to the extratropical latitudes.
Against the use of the Strengths and Difficulties Questionnaire for Aboriginal and Torres Strait Islander children aged 2–15 years
Authors: Chau Tracey , Tiego Jeggan , Brown Louise , Coghill David , Jobson Laura , Montgomery Alicia , Murrup-Stewart Cammi , Sciberras Emma , Silk Tim J , Spencer-Smith Megan , Stefanac Nicole , Sullivan Daniel P , Bellgrove Mark A
Published: March 2023

Objective:

The Strengths and Difficulties Questionnaire is a widely used screening tool for emotional and behavioural problems in children. Recent quantitative analyses have raised concerns regarding its structural validity in Aboriginal and Torres Strait Islander communities. This paper aims to extend upon existing findings by analysing the factor structure of both the parent- and teacher-reported Strengths and Difficulties Questionnaire in this population across a broader age range than in previous studies.

Methods:

Participants were the caregivers and teachers of 1624 Aboriginal and Torres Strait Islander children (820 male, 804 female) aged 2–15 years from Waves 2–11 of the Longitudinal Study of Indigenous Children. The majority of children were Aboriginal living in major cities and inner regional areas. Internal consistency was estimated with McDonald’s Omega. Exploratory structural equation modelling was conducted to investigate the factor structure of the parent-reported and teacher-reported versions of the Strengths and Difficulties Questionnaire.

Results:

Responses from teachers demonstrated higher internal consistency than responses from parents, which was unacceptably low across most age groups. The purported five-factor structure of the Strengths and Difficulties Questionnaire failed to be replicated across both parent- and teacher-reported questionnaires. The results of bifactor and hierarchical exploratory structural equation models also failed to approximate the higher-order summary scales. These results indicate that the Strengths and Difficulties Questionnaire subscales and summary scores do not provide a valid index of emotional and behavioural problems in Aboriginal and Torres Strait Islander children.

Conclusion:

The Strengths and Difficulties Questionnaire should not be used with Aboriginal and Torres Strait Islander children.
The Moral Career of Soldiers’ Identity: A Norwegian Case
Authors: Kaspersen Iselin Silja
Published: March 2023

Military service can require soldiers to act beyond their moral beliefs, something that can impair soldiers’ mental health. However, little is known about the shaping of soldiers’ moral identity within their institutional context. This article explores how the moral identity of 20 experienced Norwegian soldiers is (re-)shaped in the Army. Findings from unstructured interviews suggest that they accept compromising their moral beliefs and give priority to an institutional obligation to follow orders. They present three mediating arguments justifying such a compromise and one effort to reduce the potential burden of carrying out illegal or immoral orders. I argue that these compromises are made possible through a shared belief they are socialized into through interactions in their military context. The study complements our knowledge of socialization processes in the military and identifies two theoretical concepts useful to gain knowledge about the (re-)shaping of soldiers’ moral identity.
Risk and Uncertainty in France's Atlantic Slave Trade
Authors: Hope Mallory
Published: March 2023

In the eighteenth century, about 12% of Atlantic slave-trading voyages organized under the French flag ended in shipwreck, condemnation of the vessel by Admiralty authorities, capture by privateers or pirates, or with the enslaved men and women on board taking control of the ship. During this period, a commercial solution was available to insulate slave traders from the financial losses that shipwreck, capture, and revolts represented to them: marine insurance policies, written to cover the estimated value of enslaved people and slaving vessels. According to early modern merchant manuals and legal commentaries, insurance underwriters compensated losses during slave-trading ventures according to stable principles that were consistent throughout the Atlantic world. In this article, however, I explore new evidence beyond these published sources by comparing the terms of 13 marine insurance policies underwritten in France to cover investments in slave-trading ships and in enslaved people. In these contracts, we find that purchasers of insurance coverage and underwriters added conditions not foreseen in merchants’ and lawyers’ manuals, as well as lines that contradicted the terms such guidebooks and commentaries claimed were standard. Marine insurance policies that covered slave-trading ships were used to hand off the possible financial fallout from profoundly unpredictable situations—not only conflicts between European powers, but also violent encounters between enslavers and captives, between European and African slave traders, and wars between African kingdoms. Insurance policies underwritten on the hulls and cargoes of slave ships thus show that marine insurance in the early modern world was a tool for redistributing both Knightian risk and Knightian uncertainty.
Reducing turnover intentions among first-year nurses: The importance of work centrality and coworker support
Authors: Andrews Martha C. , Woolum Andrew , Mesmer-Magnus Jessica , Viswesvaran Chockalingam , Deshpande Satish
Published: March 2023

Turnover among nurses has been recognized as a frequent and enduring problem in healthcare worldwide. The widespread nursing shortage has reached the level of a healthcare crisis. The COVID-19 pandemic has illustrated the importance of understanding the contributing factors of nurse turnover, and more importantly how to mitigate the problem. Using cross-sectional survey data collected from 3370 newly licensed nurses working across 51 metropolitan areas within 35 U.S. states, we explore how role overload and work constraints can both diminish job satisfaction and increase turnover intentions of new nurses. Coworker support and work role centrality are identified as moderators of these relationships which show potential to mitigate these negative outcomes. This study highlights the importance of coworker support and work centrality in improving job satisfaction and subsequent turnover intentions among newly licensed nurses.
Sitagliptin attenuates neuronal apoptosis via inhibiting the endoplasmic reticulum stress after acute spinal cord injury
Authors: Tang Chengxuan , Xu Tianzhen , Dai Minghai , Zhong Xiqiang , Shen Guangjie , Liu Liangle
Published: March 2023

Regulation of endoplasmic reticulum stress (ER) stress-induced apoptosis and nerve regeneration is a hopeful way for acute spinal cord injury (SCI). Sitagliptin (Sita) is one of dipeptidyl peptidase-4 (DPP-4) inhibitor, which is beneficial neurons damaged diseases. However, its protective mechanisms of avoiding nerve injury remain unclear. In this study, we further investigated the mechanism of the anti-apoptotic and neuroprotective effects of Sita in promoting locomotor recovery from SCI. In vivo results showed that Sita treatment reduced neural apoptosis caused by SCI. Moreover, Sita effectively attenuated the ER tress and associated apoptosis in rats with SCI. A striking feature was the occurrence of nerve fiber regeneration at the lesion site, which eventually led to significant locomotion recovery. In vitro results showed that the PC12 cell injury model induced by Thapsigargin (TG) also showed similar neuroprotective effects. Overall, sitagliptin showed potent neuroprotective effects by targeting the ER stress-induced apoptosis both in vivo and vitro, thus facilitating the regeneration of the injured spinal cord.
Incidence, Patterns, and Severity of Potential Drug Interactions Among Cancer Patients on Chemotherapy in a Tertiary Care Hospital
Authors: H.V. Anuradha , Maka Vinayak V. , Patil Prakash , C. Anupama
Published: March 2023

Objective

To study the incidence of potential drug−drug interactions (DDIs) and evaluate their pattern and severity in cancer inpatients.

Materials and Methods

A detailed clinical data and prescriptions of 150 inpatients with different malignancies were subjected to DDI screening using Micromedex software. The frequency of potential DDIs and their types, patterns, and severity were investigated.

Results

A total of 360 potential DDIs were present in 111 (74%) of 150 inpatients, dominated by female (67.33%) and breast cancer (30%) patients. The incidence of severe interactions was 63.88%, moderate interactions 35.83%, and mild interactions 0.27%. The potential mechanisms of DDIs were 38.33% pharmacodynamic, 48.33% pharmacokinetic, and 13.33% unspecified. The drug interactions were found to be positively correlated ( p < 0.01) with the 6–10 number of prescribed medicines.

Conclusion

According to this study, the number of medicines prescribed to cancer inpatients increased the chance of DDIs. As a result, the drug surveillance program could save a sizable number of patients from the potentially hazardous clinical effects of DDIs.
Origins of financial analysts in the United States
Authors: Jimenez-Andrade Jesus R.
Published: March 2023

Since the United States securities market's creation and promulgation of the Investment Advisers Act in 1940, financial analysts transitioned from a highly unregulated practice to one of the most heavily regulated professions. Relying on multiple formal archival sources, this article explores the antecedents behind this bolstering event. Applying a chronological historical analysis, findings suggest that three factors forced regulators to intervene: the unethical abuses uncovered by a committee with highly specialised skills, the inability of financial analysts to adhere to ethical practices and professional segregation combined with absent collective institutional values. These findings illustrate the regulatory consequences in collective sanctioning cases (rather than criminal or economic penalties imposed on specific individuals). A socio-economic historical triangulation enriches the quality of these findings.
Economic Shocks and Fiscal Policy Preferences: Evidence From COVID-19 in Spain
Authors: Jurado Ignacio , Kuo Alexander
Published: March 2023

Do negative economic shocks change fiscal policy preferences? We examine this question via the large COVID-19 shock, as the virus and ensuing lockdowns caused one of the largest acute economic contractions in recent history. While previous evidence that recessions meaningfully change fiscal preferences is limited, we hypothesize that the health pandemic should have had distinct effects. We argue that this is due to the large breadth, uncertainty, and socio-tropic basis of the economic contraction, and that worse economic evaluations and reduced economic optimism should correspond with greater support for fiscal interventions to address the crisis. To test these hypotheses, we use new panel evidence from Spain, a hard-hit country, surveying individuals prior to the pandemic and the same individuals during the pandemic. We find that individuals became more economically pessimistic across many measures. However, there is little evidence that this translates into support for more expansive fiscal policies. Second, we find through a framing experiment that this could be because individuals believe that the government’s fiscal policies would disproportionately benefit lower-income individuals. The findings indicate the theoretical importance of recessions for changing individual and socio-tropic economic expectations, but do not support the claim that large economic shocks can significantly change fiscal preferences.
Punishment as text
Authors: Dagan Netanel , Zimran Adiel
Published: March 2023

Punishment is often performed through judicial texts. Narrative criminology scholarship, however, has paid little attention to how criminalised people engage with these texts when constructing their self-narratives. To fill this gap, based on qualitative findings from formerly incarcerated people in Israel, this paper aimed to theorise their engagement with their sentencing remarks (SR). We found that they experienced their SR as text that held communicative, transformative and physical dimensions. The findings showed that SR impacted criminalised persons by individualising the penal dialogue, transforming their identity, and serving as objects for performing rituals during their imprisonment and upon release. The findings contribute to an understanding of the connection between judicial work and incarcerated people's desistance and identity-making processes through the textual bridge of SR.
Factors associated with adherence and viral suppression among patients on second-line antiretroviral therapy in an urban HIV program in Kenya
Authors: Nyaboke Rose , Ramadhani Habib Omari , Lascko Taylor , Awuor Patrick , Kirui Elvis , Koech Emily , Mutisya Immaculate , Ngunu Carol , Wangusi Rebecca
Published: March 2023

Objective:

The aim of this study is to estimate the proportion of virologically suppressed People living with HIV on second-line ART and to identify factors associated with virologic suppression. With an increasing population of patients on complex second-line anti retroviral therapy (ART), understanding the factors associated with viral suppression and adherence is critical for ensured longevity of ART.

Methods:

A retrospective study was conducted of patients on second-line ART in 17 facilities supported by University of Maryland, Baltimore, in Nairobi, Kenya, covering the period beginning October 2016 up to August 2019. Viral suppression was defined as viral load <1000 copies/mL in a test conducted in the last 12 months. Adherence was assessed through self-reports and classified as optimal (good) or suboptimal (inadequate/poor). Associations were presented as adjusted risk ratios with 95% confidence intervals. Statistical significance was considered when p value ⩽0.05.

Results:

Of 1100 study participants with viral load data, 974 (88.5%) reported optimal adherence while on first-line ART and 1029 (93.5%) reported optimal adherence to second-line ART. Overall, viral load suppression on second-line ART was 90%. Optimal adherence ((adjusted risk ratio) 1.26; 95% confidence interval 1.09–1.46)) and age 35–44 versus 15–24 years ((adjusted risk ratio) 1.06; 95% confidence interval 1.01–1.13)) were associated with viral suppression . Adherence to first-line ART ((adjusted risk ratio) 1.19; 95% confidence interval 1.02–1.40)) was associated with adherence to second-line ART.

Conclusion:

Viral suppression remains high and adherence was strongly associated with viral suppression, underscoring the need to adequately address the barriers to adherence before switching regimens.
Humane dog food? caring and killing in the certified humane dog food value chain
Authors: Baker Carly
Published: March 2023

The marketing of dog food influences pet-owners to nurture the ‘carnivorous’ nature of the dog, keeping animal-based protein central to the industry. Alas, dog food has a significant impact on welfare. Consumers are aware of this impact, shifting the industry towards alternative pet food movements such as Open Farm, the first certified humane food. This article examines the material and discursive practices through which ‘humaneness’ is constituted as a quality within the humane pet food supply chain and how it reinforces embedded animal hierarchies. By reviewing the marketing and history of commercial dog food production, I show how ‘caring’ for the carnivorous dog lays the framework for killing. I use Open Farm's transparency tool to trace the value chain and compare it with the imagery, discursive claims, and material practices found within the Global Animal Partnership standards. I argue that instead of questioning animal-based protein, humane certification creates an alternative in which the pet owner could still ‘care’ for the wildness of their domesticated dog while simultaneously ‘caring’ for farmed animals. Thus, it reinforces the hierarchies of the industry. Additionally, the validity of the humane claims depends on the animals’ charisma and proximity to humans. In other words, marketing in the humane dog food supply chain creates animal–animal positionalities, in which the animals’ care or killability is mediated through the humans’ supply chain and marketing. However, as I show with interview data, the hierarchies are fragile and must be continuously reinforced, as animals can slip into different positions. Their proximity to humans alters their positionality and their killability.
Central retinal vein occlusion associated with Bartonella henselae infection
Authors: Bellur Sunil , Ali Amir , Nguyen Nam V. , Fernandes Joshua K. , Kodati Shilpa
Published: March 2023

Purpose

To report the clinical features and treatment course of a case of central retinal vein occlusion (CRVO) as the initial sign of ocular Bartonella henselae (B. henselae) infection.

Observation

A 36-year-old male was evaluated for unilateral vision loss. He denied prodromal symptoms but reported prior exposure to fleas. Best corrected visual acuity (BCVA) was 20/400 in the left eye. Clinical examination revealed a CRVO with atypical features including significant peripapillary exudates and peripheral vascular sheathing. Laboratory testing revealed elevated B. henselae IgG titers (1:512) with no abnormalities on hypercoagulability testing. The patient was treated with doxycycline and aflibercept with an excellent clinical response and improvement in BCVA to 20/25 in the left eye two months later.

Conclusion

CRVO is a rare but sight-threatening complication of ocular bartonellosis and can be the presenting sign of infection, even in the absence of cat exposure or prodromal symptoms.
CenFind: a deep-learning pipeline for efficient centriole detection in microscopy datasets
Authors: Bürgy Léo , Weigert Martin , Hatzopoulos Georgios , Minder Matthias , Journé Adrien , Rahi Sahand Jamal , Gönczy Pierre
Published: March 2023

Background

High-throughput and selective detection of organelles in immunofluorescence images is an important but demanding task in cell biology. The centriole organelle is critical for fundamental cellular processes, and its accurate detection is key for analysing centriole function in health and disease. Centriole detection in human tissue culture cells has been achieved typically by manual determination of organelle number per cell. However, manual cell scoring of centrioles has a low throughput and is not reproducible. Published semi-automated methods tally the centrosome surrounding centrioles and not centrioles themselves. Furthermore, such methods rely on hard-coded parameters or require a multichannel input for cross-correlation. Therefore, there is a need for developing an efficient and versatile pipeline for the automatic detection of centrioles in single channel immunofluorescence datasets.

Results

We developed a deep-learning pipeline termed CenFind that automatically scores cells for centriole numbers in immunofluorescence images of human cells. CenFind relies on the multi-scale convolution neural network SpotNet, which allows the accurate detection of sparse and minute foci in high resolution images. We built a dataset using different experimental settings and used it to train the model and evaluate existing detection methods. The resulting average F1-score achieved by CenFind is > 90% across the test set, demonstrating the robustness of the pipeline. Moreover, using the StarDist-based nucleus detector, we link the centrioles and procentrioles detected with CenFind to the cell containing them, overall enabling automatic scoring of centriole numbers per cell.

Conclusions

Efficient, accurate, channel-intrinsic and reproducible detection of centrioles is an important unmet need in the field. Existing methods are either not discriminative enough or focus on a fixed multi-channel input. To fill this methodological gap, we developed CenFind, a command line interface pipeline that automates cell scoring of centrioles, thereby enabling channel-intrinsic, accurate and reproducible detection across experimental modalities. Moreover, the modular nature of CenFind enables its integration in other pipelines. Overall, we anticipate CenFind to prove critical for accelerating discoveries in the field.
REDfold: accurate RNA secondary structure prediction using residual encoder-decoder network
Authors: Chen Chun-Chi , Chan Yi-Ming
Published: March 2023

Background

As the RNA secondary structure is highly related to its stability and functions, the structure prediction is of great value to biological research. The traditional computational prediction for RNA secondary prediction is mainly based on the thermodynamic model with dynamic programming to find the optimal structure. However, the prediction performance based on the traditional approach is unsatisfactory for further research. Besides, the computational complexity of the structure prediction using dynamic programming is $$O(N^3)$$

O
(

N
3

)

; it becomes $$O(N^6)$$

O
(

N
6

)

for RNA structure with pseudoknots, which is computationally impractical for large-scale analysis.

Results

In this paper, we propose REDfold, a novel deep learning-based method for RNA secondary prediction. REDfold utilizes an encoder-decoder network based on CNN to learn the short and long range dependencies among the RNA sequence, and the network is further integrated with symmetric skip connections to efficiently propagate activation information across layers. Moreover, the network output is post-processed with constrained optimization to yield favorable predictions even for RNAs with pseudoknots. Experimental results based on the ncRNA database demonstrate that REDfold achieves better performance in terms of efficiency and accuracy, outperforming the contemporary state-of-the-art methods.
A case report of an atypical haemolytic uremic syndrome in pregnancy: something wicked this way comes
Authors: Catarci Stefano , Zanfini Bruno Antonio , Di Muro Mariangela , Capone Emanuele , Frassanito Luciano , Santantonio Maria Teresa , Draisci Gaetano
Published: March 2023

Background

Atypical Haemolytic Uremic Syndrome is an acute life-threatening condition, characterized by the clinical triad of microangiopathic hemolytic anaemia, thrombocytopenia, kidney injury. Management of pregnants affected by Atypical Haemolytic Uremic Syndrome can be a serious concern for obstetric anesthesiologist in the delivery room and in the intensive care unit.

Case presentation

A 35-year-old primigravida with a monochorionic diamniotic twin pregnancy, presented with an acute haemorrhage due to retained placenta after elective caesarean section and underwent surgical exploration. In the postoperative period, the patient progressively developed hypoxemic respiratory failure and, later on, anaemia, severe thrombocytopenia, and acute kidney injury. A timely diagnosis of Atypical Haemolytic Uremic Syndrome was made.

Non-invasive ventilation and high-flow nasal cannula oxygen therapy sessions were initially required. Hypertensive crisis and fluid overload were aggressively treated with a combination of beta and alpha adrenergic blockers (labetalol 0,3 mg/kg/h by continuous intravenous infusion for the first 24 hours, bisoprolol 2,5 mg twice daily for the first 48 hours, doxazosin 2 mg twice daily), central sympatholytics (methyldopa 250 mg twice daily for the first 72 hours, transdermal clonidine 5 mg by the third day), diuretics (furosemide 20 mg three times daily), calcium antagonists (amlodipine 5 mg twice daily).

Eculizumab 900 mg was administered via intravenous infusion once per week, attaining hematological and renal remissions. The patient also received several blood transfusion units and anti- meningococcal B, anti-pneumococcal, anti-haemophilus influenzae type B vaccination.

Her clinical condition progressively improved, and she was finally discharged from intensive care unit 5 days after admission.

Conclusions

The clinical course of this report underlines how crucial it is for the obstetric anaesthesiologist to promptly identify Atypical Haemolytic Uremic Syndrome, since early initiation of eculizumab, together with supportive therapy, has a direct effect on patient outcome.
Response to COVID-19 recommended preventive behavioral messages among Guraghe zone communities, South Ethiopia: using constructs of the Extended Parallel Process Model (EPPM)
Authors: Kemal Abdurezak , Assfa Kenzudin , Zeleke Bisrat , Jemal Mohammed , Jemal Musa , Kedir Shemsu , Zewdie Amare , Dessu Samuel , Yassin Fedila , Habtie Adane
Published: March 2023

Introduction

The World Health Organization declared COVID-19 is a pandemic disease. Countries should take standard measures and responses to battle the effects of the viruses. However, little is known in Ethiopia regarding the recommended preventive behavioral messages responses. Therefore, the study aimed to assess the response to COVID-19 recommended preventive behavioral messages.

Methods

Community-based cross-sectional study design was carried out from 1 to 20, July 2020. We recruited 634 respondents by using a systematic sampling method. Data were analyzed using Statistical Package Software for Social Sciences version 23. Association between variables were explored using a bivariable and multi variable logistic regression model. The strength of the association is presented using odds ratio and regression coefficient with 95% confidence interval. A p-value of less than 0.05 was declared statistically significant.

Results:

Three hundred thirty-six (53.1%) of respondents had good response to recommended preventive behavioral messages. The general precise rate of the knowledge questionnaire was 92.21%. The study showed that merchant was 1.86 (p ≈ 0.01) times more likely respond to COVID-19 recommended preventive behavioral messages than government-employed. Respondents who scored one unit increase for self-efficacy and response-efficacy, the odds of responding to COVID-19 recommended preventive behavioral messages were increased by 1.22 (p < 0.001), and 1.05 times (p = 0.002) respectively. Respondents who scored one unit increase to cues to action, the odds of responding to COVID-19 recommended preventive behavioral messages were 43% (p < 0.001) less likely.

Conclusion

Even though respondents were highly knowledgeable about COVID-19, there is a lower level of applying response to recommended preventive behavioral messages. Merchant, self-efficacy, response efficacy, and cues to action were significantly associated with response to recommended preventive behavioral messages. Like merchants, government employer should be applying preventive behavioral messages and also, participants’ self and response efficacy should be strengthened to improve the response. In addition, we should be changed or modified the way how-to deliver relevant information, promoting awareness, and also using appropriate reminder systems to preventive behavioral messages.
Relationship between antipsychotic medication and aggressive events in patients with a psychotic disorder hospitalized for treatment
Authors: Tseligkaridou Georgia , Egger Stephan T. , Spiller Tobias R. , Schneller Lena , Frauenfelder Fritz , Vetter Stefan , Seifritz Erich , Burrer Achim
Published: March 2023

Background

Disruptive and aggressive behavior is frequent in patients with a psychotic disorder; furthermore, it is a recurrent reason for compulsory admission. Even during treatment, many patients continue to show aggressive behavior. Antipsychotic medication is posed to have anti-aggressive properties; its prescription is a common strategy for the treatment (and prevention) of violent behavior. The present study aims to investigate the relation between the antipsychotic class, according to the dopamine D2-Receptor binding affinity (i.e., “loose” – “tight binding”), and aggressive events perpetrated by hospitalized patients with a psychotic disorder.

Methods

We conducted a four-year retrospective analysis of legally liable aggressive incidents perpetrated by patients during hospitalization. We extracted patients’ basic demographic and clinical data from electronic health records. We used the Staff Observation Aggression Scale (SOAS-R) to grade the severity of an event. Differences between patients with a “loose” or “tight-binding” antipsychotic were analyzed.

Results

In the observation period, there were 17,901 direct admissions; and 61 severe aggressive events (an incidence of 0.85 for every 1,000 admissions year). Patients with a psychotic disorder perpetrated 51 events (incidence of 2.90 for every 1,000 admission year), with an OR of 15.85 (CI: 8.04–31.25) compared to non-psychotic patients. We could identify 46 events conducted by patients with a psychotic disorder under medication. The mean SOAS-R total score was 17.02 (2.74). The majority of victims in the “loose-binding” group were staff members (73.1%, n = 19), while the majority of victims in the “tight-binding” group were fellow patients (65.0%, n = 13); (X2(3,46) = 19.687; p < 0.001). There were no demographic or clinical differences between the groups and no differences regarding dose equivalents or other prescribed medication.

Conclusions

In aggressive behaviors conducted by patients with a psychotic disorder under antipsychotic medication, the dopamine D2-Receptor affinity seems to have a high impact on the target of aggression. However, more studies are needed to investigate the anti-aggressive effects of individual antipsychotic agents.
The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis
Authors: Wu Chao , Wang Wenwen , Cheng Sizhe , Zhang Hongli , Li Lu , Tian Ci , Zhang Linyuan , Chen Nana , Du Juan , Ren Lei , Lang Hongjuan
Published: March 2023

Background

The fear of hypoglycemia in type 2 diabetes mellitus (T2DM) patients with hypoglycemia has seriously affected their quality of life. They are always afraid of hypoglycemia and often take excessive action to avoid it. Yet, researchers have investigated the relationship between hypoglycemia worries and excessive avoiding hypoglycemia behavior using total scores on self-report measures. However, network analysis studies of hypoglycemia worries and excessive avoiding hypoglycemia behavior in T2DM patients with hypoglycemia are lacking.

Purpose

The present study investigated the network structure of hypoglycemia worries and avoiding hypoglycemia behavior in T2DM patients with hypoglycemia and aimed to identify bridge items to help them correctly treat hypoglycemia and properly deal with hypoglycemia fear.

Methods

A total of 283 T2DM patients with hypoglycemia were enrolled in our study. Hypoglycemia worries and avoiding hypoglycemia behavior were evaluated with the Hypoglycemia Fear Scale. Network analyses were used for the statistical analysis.

Results

B9 “Had to stay at home for fear of hypoglycemia” and W12 “I am worried that hypoglycemia will affect my judgment” have the highest expected influences in the present network. In the community of hypoglycemia worries, W17 “I worry about hypoglycemia during sleep” has the highest bridge expected influence. And in the community of avoiding hypoglycemia behavior, B9 “Had to stay at home for fear of hypoglycemia” has the highest bridge expected influence.

Conclusion

Complex patterns of associations existed in the relationship between hypoglycemia worries and avoiding hypoglycemia behavior in T2DM patients with hypoglycemia. From the perspective of network analysis, B9 “Had to stay at home for fear of hypoglycemia” and W12 “I am worried that hypoglycemia will affect my judgment” have the highest expected influence, indicating their highest importance in the network. W17 “I worry about hypoglycemia during sleep” aspect of hypoglycemia worries and B9 “Had to stay at home for fear of hypoglycemia” aspect of avoiding hypoglycemia behavior have the highest bridge expected influence, indicating they have the strongest connections with each community. These results have important implications for clinical practice, which provided potential targets for interventions to reduce hypoglycemia fear and improve the quality of life in T2DM patients with hypoglycemia.
The effect of cognitive-behavioral therapy and sexual health education on sexual assertiveness of newly married women
Authors: Jangi Sanaz , Nourizadeh Roghaiyeh , Sattarzadeh-Jahdi Niloufar , Farvareshi Mahmoud , Mehrabi Esmat
Published: March 2023

Background

The present study aimed at investigating the effect of sexual health education and cognitive-behavioral therapy (CBT) on sexual assertiveness (primary outcome) and sexual satisfaction (secondary outcome) of newly married women.

Method

This RCT was conducted on 66 newly married women with cases in pre-marriage counseling centers in Tabriz, Iran. Participants were assigned into three groups using block randomization. Eight group sessions of CBT were held for one of the intervention groups (n = 22) and 5–7 sessions of sexual health education for other intervention group (n = 22). The control group (n = 22) received neither education nor counseling during the research. The data were collected using the demographic and obstetric characteristics, Hulbert sexual assertiveness index, and Larson sexual satisfaction questionnaires, and analyzed using ANOVA and ANCOVA tests.

Results

The mean (standard deviation: SD) score of the sexual assertiveness and sexual satisfaction in the CBT group enhanced from 48.77 (13.94) and 73.13 (13.53) before the intervention to 69.37 (7.28) and 86.57 (7.5) after the intervention, respectively. The mean (SD) score of the sexual assertiveness and sexual satisfaction in the sexual health education group increased from 48.9(11.39) and 74.95 (8.30) before the intervention to 66. 94 (7.42) and 84.93 (6.34) after the intervention, respectively. The mean (SD) score of the sexual assertiveness and sexual satisfaction in the control group changed from 45.04 (15.87) and 69.04 (10.75) before the intervention to 42.74 (14.11) and 66.44 (10.11) after the intervention, respectively. Eight weeks after the intervention, the mean scores of sexual assertiveness and sexual satisfaction in two intervention groups were more than that in the control group (P < 0.001), However, there was no significant difference between the two intervention groups (P > 0.05).

Conclusion

The results of this research indicated that CBT and sexual health education are effective in improving women’s sexual assertiveness and sexual satisfaction. Considering that sexual health education, does not require complex counseling skills compared to CBT, it can be used as a preferred intervention in promoting sexual assertiveness and satisfaction of newly married women.

Trial registration

Iranian Registry of Clinical Trials: IRCT20170506033834N8. Date of registration: 11.09.2021. URL:http://en.irct.ir.