bluuebunny/crossref_metadata_2025 huggingface dataset:
Passive mechanical properties of the left ventricular myocardium and extracellular matrix in hearts with chronic volume overload from mitral regurgitation
Authors: Corporan Daniella , Saadeh Maher , Yoldas Alessandra , Mudigonda Jahnavi , Lane Brooks Alexander , Padala Muralidhar
Published: July 2022

Cardiac volume overload from mitral regurgitation (MR) is a trigger for left ventricular dilatation, remodeling, and ultimate failure. While the functional and structural adaptations to this overload are known, the adaptation of myocardial mechanical properties remains unknown. Using a rodent model of MR, in this study, we discern changes in the passive material properties of the intact and decellularized myocardium. Eighty Sprague‐Dawley rats (350–400 g) were assigned to two groups: (1) MR (n = 40) and (2) control (n = 40). MR was induced in the beating heart by perforating the mitral leaflet with a 23G needle, and rats were terminated at 2, 10, 20, or 40 weeks (n = 10/time‐point). Echocardiography was performed at baseline and termination, and explanted hearts were used for equibiaxial mechanical testing of the intact myocardium and after decellularization. Two weeks after inducing severe MR, the myocardium was more extensible compared to control, however, stiffness and extensibility of the extracellular matrix did not differ from control at this timepoint. By 20 weeks, the myocardium was stiffer with a higher elastic modulus of 1920 ± 246 kPa, and a parallel rise in extracellular matrix stiffness. Despite some matrix stiffening, it only contributed to 31% and 36% of the elastic modulus of the intact tissue in the circumferential and longitudinal directions. At 40 weeks, similar trends of increasing stiffness were observed, but the contribution of extracellular matrix remained relatively low. Chronic MR induces ventricular myocardial stiffening, which seems to be driven by the myocyte compartment of the muscle, and not the extracellular matrix.
Appropriated protection time and region for Qinghai–Tibet Plateau grassland
Authors: Qian Shuan , Pan Feifei , Wu Menxin , Sun Yinglong
Published: July 2022

Grassland accounts for 67% of the land area in Qinghai–Tibet Plateau (QTP) to sensitive to climate. This article carried out extensive temporal–spatial variations of grassland water deficit/surplus (GWDS) and net primary productivity (NPP) of QTP grassland using meteorological data of 1981–2018. The results indicate that precipitation’s temporal variations are not related to potential evapotranspiration (PET). The maximum monthly precipitation occurs in July, while the maximum monthly PET appears in June. Precipitation is the second highest in spring when PET is the highest. The water deficit (PET-precipitation) from March to June takes up 51.4% of the total year. Therefore, droughts are more likely to happen in spring and June. This is the most important period for grassland protection. Water deficit is higher in the central and west and the highest in the northwest of QTP grasslands. This indicates the place where the droughts are more likely to occur. The grassland’s annual NPP is high in the southeastern part of QTP and low in the west. This shows the central and western parts of QTP grassland should receive more attention. The specific time and region obtained in this study are important for environmental protection policy-making and reducing grassland degradation in QTP.
Convergence analysis of iteratively regularized Gauss–Newton method with frozen derivative in Banach spaces
Authors: Mittal Gaurav , Giri Ankik Kumar
Published: July 2022

In this paper, we consider the iteratively regularized Gauss–Newton method with frozen derivative and formulate its convergence rates in the settings of Banach spaces. The convergence rates of iteratively regularized Gauss–Newton method with frozen derivative are well studied via generalized source conditions. We utilize the recently developed concept of conditional stability of the inverse mapping to derive the convergence rates. Also, in order to show the practicality of this paper, we show that our results are applicable on an ill-posed inverse problem. Finally, we compare the convergence rates derived in this paper with the existing convergence rates in the literature.
An estimation of HOMO–LUMO gap for a class of molecular graphs
Authors: Hameed Saira , Alamer Ahmed , Javaid Muhammad , Ahmad Uzma
Published: July 2022

For any simple connected graph G of order n, having eigen spectrum μ
1 ≥ μ
2 ≥ ⋯ ≥ μ

n
with middle eigenvalues μ
H and μ
L, where H = ⌊(n + 1)/2⌋ and L = ⌈(n + 1)/2⌉, the HOMO–LUMO gap is defined as as ΔG = μ
H = μ
L. In this article, a simple upper bound for the HOMO–LUMO gap corresponding to a special class of connected bipartite graphs is estimated. As an application, the upper bounds for the HOMO–LUMO gap of certain classes of nanotubes and nanotori are estimated.
Reframing Public Art in the Borderlands
Authors: Thomas Mary
Published: July 2022

This article examines a series of public artworks created by Jari “WERC” Alvarez and Gera “GERALUZ” Lozano both singly and together between 2009 and 2013 in San Diego, California, and El Paso, Texas. Although the works produced then reveal an engagement with the history of Chicano muralism and visual representations of the US-Mexico border, Lozano and Alvarez’s projects offer a careful recuperation of the way the region and the site of the border are represented through their stylistic vocabularies that span graffiti, abstraction, and conceptual practice. This essay argues that the artists enact this reparative relationship through a “bricozaje” aesthetic orientation, which refers to the adaptation of bricolage techniques by artists whose work directly engages the fragmented space of the border and integrates the heterogeneous experiences that mark the experience of moving within and between cultural and artistic borderlands.
“That Peculiarly Spanish Style”
Authors: Schreffler Michael
Published: July 2022

The architectural forms associated with the aesthetic phenomenon that has come to be known as mudéjar and visual elements tied to Iberian and Islamic architectural traditions more broadly have been interpreted across modern Latin America in various modes. A wide array of buildings spanning from the colonial era into the twentieth century engage with this architectural legacy and distinctly stand out within the urban fabric of the continent’s major capitals today. Whether reflected in the intricately geometric woodwork of colonial-era ceilings known as carpentería de lo blanco or via the mashrabiya-inspired screened breezeways that punctuate modern Brazilian pavilions, such architectonic techniques and design criteria evoke imaginaries tied to South America’s colonial past via references to an Ibero-Islamic aesthetic. Recent calls to reexamine diverse historiographic and architectonic interpretations of the so-called mudéjar or other revivalist forms associated with the Islamic world in Latin America, along with their connections to nationalism and orientalism, invite a critical reconsideration of these constructions from a decolonial perspective within this regional context. Responding to these inquiries, this dialectical collection of essays spans diverse geographies and periods to expand upon contemporary interrogations of modern historiographic and design interpretations of the built forms associated with the mudéjar and Ibero-Islamic architectural traditions in modern Latin America. Together, they present fresh case studies and perspectives while asserting that a strategic reading of the stylistic phenomenon and its architectural echoes in Latin America is not simply the result of an external influence in the region but part of a broader complex discourse of modernity.
Azulejos neo-árabes en la arquitectura de Buenos Aires (1920–1950)
Authors: Girelli Francisco
Published: July 2022

The architectural forms associated with the aesthetic phenomenon that has come to be known as mudéjar and visual elements tied to Iberian and Islamic architectural traditions more broadly have been interpreted across modern Latin America in various modes. A wide array of buildings spanning from the colonial era into the twentieth century engage with this architectural legacy and distinctly stand out within the urban fabric of the continent’s major capitals today. Whether reflected in the intricately geometric woodwork of colonial-era ceilings known as carpentería de lo blanco or via the mashrabiya-inspired screened breezeways that punctuate modern Brazilian pavilions, such architectonic techniques and design criteria evoke imaginaries tied to South America’s colonial past via references to an Ibero-Islamic aesthetic. Recent calls to reexamine diverse historiographic and architectonic interpretations of the so-called mudéjar or other revivalist forms associated with the Islamic world in Latin America, along with their connections to nationalism and orientalism, invite a critical reconsideration of these constructions from a decolonial perspective within this regional context. Responding to these inquiries, this dialectical collection of essays spans diverse geographies and periods to expand upon contemporary interrogations of modern historiographic and design interpretations of the built forms associated with the mudéjar and Ibero-Islamic architectural traditions in modern Latin America. Together, they present fresh case studies and perspectives while asserting that a strategic reading of the stylistic phenomenon and its architectural echoes in Latin America is not simply the result of an external influence in the region but part of a broader complex discourse of modernity.
miR‐124‐dependent tagging of synapses by synaptopodin enables input‐specific homeostatic plasticity
Authors: Dubes Sandra , Soula Anaïs , Benquet Sébastien , Tessier Béatrice , Poujol Christel , Favereaux Alexandre , Thoumine Olivier , Letellier Mathieu
Published: July 2022

Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on a neuron respond uniformly to the same perturbation remains unclear. Moreover, the molecular determinants that underlie synapse‐specific homeostatic synaptic plasticity are unknown. Here, we report a synaptic tagging mechanism in which the ability of individual synapses to increase their strength in response to activity deprivation depends on the local expression of the spine‐apparatus protein synaptopodin under the regulation of miR‐124. Using genetic manipulations to alter synaptopodin expression or regulation by miR‐124, we show that synaptopodin behaves as a “postsynaptic tag” whose translation is derepressed in a subpopulation of synapses and allows for nonuniform homeostatic strengthening and synaptic AMPA receptor stabilization. By genetically silencing individual connections in pairs of neurons, we demonstrate that this process operates in an input‐specific manner. Overall, our study shifts the current view that homeostatic synaptic plasticity affects all synapses uniformly to a more complex paradigm where the ability of individual synapses to undergo homeostatic changes depends on their own functional and biochemical state.
Mapping Ancient Architecture via Unpiloted Aerial Vehicle–acquired LiDAR: A Case Study of Hōlualoa Royal Centre, Kona District, Hawai‘i Island
Authors: McCoy Mark D. , Casana Jesse , Hill Austin Chad , Laugier Elise Jakoby , Ladefoged Thegn N.
Published: July 2022

At present there is no systematic record of the size, form or density of architecture at Hawaiian royal centres. We report on the results of a UAV LiDAR survey of one of the best-preserved examples of a royal centre in the archipelago: Hōlualoa Royal Centre, Kona District, Hawai‘i Island. The resolution of our data (0.3–0.1 m) is far superior to previous airborne LiDAR surveys (1.0 m); however, several factors, including thick understory vegetation, made resolving archaeological targets challenging. We nonetheless were able measure the volume of building material of the largest features, which allows us to compare structures in this royal centre with other monuments in the region. This study highlights the advantages, and limitations, of UAV LiDAR as well as the need for more high-quality quantitative data on architecture at royal centres.
Vertigo and Ischemic Stroke after Hyperextension (Beauty Parlour Stroke syndrome)
Authors: Tosunoğlu Bünyamin , Ünal Sultan Merve , Aksoy Seyfi Emre , Yoldaş Tahir Kurtuluş
Published: July 2022

Beauty parlour stroke syndrome is a stroke syndrome that occurs secondary to hyperextension of the neck due to compression of the vertebral artery in the atlanto-occipital region. It was first defined as “pearl beauty stroke syndrome” in 1992 by Weintraub et al. Vertigo syndrome caused by cervical region pathologies, bad posture of the neck and/or trauma [1]. We present a young, 23-year-old patient who has no disease, no trauma history nor substance-drug use. He was diagnosed with vertigo that started after going to the barber’s and then had an infarction in the cerebellum.
Polycystic Horseshoe Kidney: A Rare Coexistence as a Challenge for the Surgeons. Case Report
Authors: Prevezanos Dionysios , Garmpis Nikolaos , Dimitroulis Dimitrios , Garmpi Anna , Georgakopoulou Vasiliki Epameinondas , Damaskos Christos
Published: July 2022

Autosomal dominant polycystic kidney disease (ADPKD) with concomitant horseshoe kidney is an extremely rare entity. In this case, we report a 45-year-old male patient with ADPKD and a horseshoe kidney who demonstrated hypertension, urological complications and discomfort symptoms such as pain, breathing difficulties and abdominal meteorism. After preoperative assessment and planning, the patient underwent nephrectomy. Bilateral nephrectomy without dividing the isthmus was performed successfully. The isthmus, which had complicated vasculature and was full of cysts, remained intact avoiding severe bleeding and infection. The postoperative course was uneventful. Keeping the isthmus intact in such cases is a challenge for the surgeon. The rarity of polycystic horseshoe kidney in combination with the altered abdominal anatomy requires the proper preoperative strategy in order to avoid intraoperative complications.
All that Glitters is not Cholecystitis. A Rare Presentation of Acute Pericarditis Mimicking Cholecystitis and Review of the Literature
Authors: Garmpi Anna , Damaskos Christos , Garmpis Nikolaos , Georgakopoulou Vasiliki Epameinondas , Kaminiotis Vaios Vasileios , Diamantis Evangelos , Patsouras Alexandros , Syllaios Athanasios , Dimitroulis Dimitrios
Published: July 2022

Acute pericarditis is the most common inflammatory disorder of the pericardium, responsible for approximately 5% of visits to the emergency departments, concerning chest pain without myocardial infarction. We report a case of a 41-year-old man who presented to our hospital, complaining about retrosternal and epigastrium pain. The transthoracic echocardiogram showed pericardial effusion while the electrocardiogram and laboratory findings revealed acute pericarditis. An abdominal ultrasound revealed gallbladder edema. The pericardial effusion was treated with pericardial catheter insertion, diuretics, and nonsteroidal anti-inflammatory drugs. This case shows that acute pericarditis can be clinically presented with many ways, one of them being gallbladder edema. Furthermore, in this case-based review we present all cases of simultaneous appearance of pericarditis and acalculous cholecystitis or gallbladder edema.
Changes of infants’ motor development using corrective education
Authors: Mockevičienė Daiva , Miliūnienė Lina
Published: July 2022

The article deals with the research, the goal of which is stating the effect of corrective education on the impaired motor development of infants depending on the beginning of corrective education. In order to assess the motor development of infants the Munich functional development diagnostics was used. There participated 120 infants attending early rehabilitation service of Šiauliai consulting policlinics for children’s disease clinics. The fi rst assessment of the complex motions of infants was made in different age groups (group I – 3±0,5 months; group II – 6±0,5 months). Generalizing information in scientifi c literature about the results of evaluation of children’s motor development in different periods until the age of one who had undergone neurodynamic therapy (NDT) and taking into consideration the results of our research we can say that the essential factor deciding the success of early intervention is infant’s age at the beginning of corrective education. If complex correction begins earlier then it causes better results of psychomotor development.
Psychological well-being of future specialists in the integrated educational environment and the factors of its formation
Authors: Serdiuk Liudmyla
Published: July 2022

This paper deals with the factors affecting the psychological well-being of the person; the intensity of indexes of psychological well-being of personalities of both students with disabilities and healthy students in integrated groups has been analyzed: self-relationship, self-realization, and orientations of life-sense, interrelation of the past, present and future in the structure of psychological time of personality life have been discussed.The students with disabilities have more expressed demand in support and positive attitude to them. The reliable differences of a number of indexes of self-realization have been found, such as spontaneity (p<0,001), competency in time, value orientations, flexibility of behaviour, sensibility to oneself, self-esteem, self-understanding (p<0,05). The differences of life-sense orientations of students with disabilities are more expressed in such categories: orientation to process (p<0,001), locus of control of Self (p<0,001), and persistence in gaining the goal (p<0,05). Indexes of psychological time of personality life are expressed in the estimation of the expected span of life. Only 40 percent of students with disabilities have adequate psychological and chronicle ages but 27 per cent have overestimated and 33 per cent underestimated indexes.The great significance of social environment is shown in the process of adaptation and integration in educational environment.
Technological support in the process of interaction of the psychologist and the special teacher
Authors: Kukushkina Olga
Published: July 2022

Developmental psychology does not provide desirable results in the development of a child with special needs in the process of his or her education if the teacher does not come together with the psychologist in revealing and removing disbalance between education and development of each child. In this report the unconventional approach to use of computer technologies to support the process of interaction of the psychologist and the teacher has been considered – the “dialogue” on the problem of the relation of education and development of a child with the special needs.Developing and diagnostic computer environment “World through your window” has been created, which is special educational tools with the following functions: To make “visible” the problems of child development that are hidden in conventional education; To show how to transform the selected problems of child development into the special tasks of his/her education; To show how to correlate “steps” in child development to “steps” in a teacher’s technique.The report shows how to use this kind of special tools for revealing and removing disbalance between education and reading development of a child.
Tendencies, developments and steps toward inclusion in the education of Hungary
Authors: Simon Katalin
Published: July 2022

The present study deals with certain milestones, key steps of education process in Hungary, which leads to a modern and democratic educational sector. The study keeps the public education segment in main focus, with outlooks to changes of vocational education and training, and to steps toward inclusion. Observing the process of education focusing on the individual, it is obvious that education holds a number of key tasks regarding the social welfare, in all of the life-stages of the individual.
Art based volunteering possibilities : viewpoint of the trainers
Authors: Tolga Vuranok Turan , Ozcan Mustafa , Miliūnienė Lina , Radzevičienė Liuda
Published: July 2022

The article presents the results based on the research performed according to the EU Grundtvig project Empowering volunteering in socially disadvantaged groups of adult learning (No. LLPGRU-MP-2011_LT-00089) in 5 different European countries and Turkey as well. The role of volunteering is described as a two side activity having infl uence on trainers and volunteers expanding their social experience and knowledge of social inclusion of groups who are at social risk. The results prove that new kind of knowledge and relationship has changed signifi cantly in the process of adult education. Increasing of two side personal motivation in education process has been set up as well.
Integration of children with disabilities into school community
Authors: Leliūgienė Irena , Kaušylienė Angelė
Published: July 2022

The article describes and defi nes socio-educational conditions of the integration of children with disabilities into school community. Appropriate integration may help to successfully solve social and education problems of children with disabilities, as well as achieve their equal rights and possibilities to participate in school community. The article theoretically presents the results of the research of socio-educational conditions of integrating children with disabilities into school community.
Changes of professional value orientations of teachers in the system of postgraduate education
Authors: Bondarchuk Olena , Pecherska Hanna
Published: July 2022

The paper presents the features of changes in professional value orientations of teachers in the system of postgraduate education. The means implementing the development of the program and change of teachers’ professional value orientations was a special course-training, which provided the impact on cognitive, emotional-evaluative and behavioral components of professional value orientations. Results of the formative experiment demonstrated the possibility of the development of professional value orientations of teachers and effectiveness of the special course-training proposed for professional teacher training in the system of postgraduate education.
Links between teachers’ attachment style and social interest
Authors: Kepalaitė Albina
Published: July 2022

Quality of teachers’ and pupils’ relationships is related to peculiarities of teachers’ attachment and social interest. The dominating teachers’ insecure attachment style was identified. Female teachers more often distinguish themselves by secure and disorientated attachment style, while male teachers more often distinguish themselves by preoccupied and dismissive attachment styles. Female teachers distinguish themselves by both high and medium social interest whilst male teachers, by medium and low social interest. The majority of teachers with secure attachment style distinguish themselves by high social interest. It is assumed that there are factors that can influence the interaction between social interest and attachment style.
Domestic violence against the man: the structure of emotional experience
Authors: Alifanovienė Daiva , Šapelytė Odeta , Patkauskienė Lina
Published: July 2022

The article presents problems of domestic violence in the context of women violence against the man. Domestic violence became one of the dominating and most controversially valued conceptual areas in the scientifc discourse. The qualitative study aimed to disclose emotional experiences of the man who has experienced violence in the closest environment. The study disclosed broad and exhaustive spectrum of emotional experiences of the man who has experienced woman’s violence. Applying content analysis method, fve categories describing the structure of the man’s emotional experiences and refecting emotional experiences to be related to the very self, wife, stepmother, environment and mother-in-law were identifed.
Examining inclusive practices in Nicaraguan schools
Authors: Delkamiller Julie , Swain Kristine , Leader-Janssen Elizabeth M. , Ritzman Mitzi J
Published: July 2022

The purpose of this study was to examine Nicaraguan teachers’ efficacy for inclusive practices and current teaching practices in Nicaraguan schools as the first step in developing a special education training program. Sixty-one teachers in 15 schools completed the Teacher Efficacy of Inclusive Practice (TEIP) survey to determine their confidence in inclusive practices, collaboration and dealing with disruptive behaviors.Classroom observations were also completed to examine the environment, teaching/learning strategies, student behaviors, learning materials, and time distribution in the classroom. Results from the TEIP indicated Nicaraguan teachers were highly efficacious in inclusive practices. The survey and observation data collected provided a baseline to develop goals and objectives for a two-year special education training.
Assessment of Job Capacities of Young People with Mental Disabilities according to the Evaluation of Motor Skills
Authors: Baranauskienė Ingrida , Radzevičienė Liuda
Published: July 2022

Problem of employment talking about integration processes of people with disabilities in present economical situation is still unsolved. Changing labor market appreciates precise, productive and responsible workers. Employers look for employees who can easily deal with diffcult situations, be creative and innovative. This viewpoint concerns adults with disabilities, who have problems in fnding and keeping job after fnishing training in professional rehabilitation centers. The aim of this research is to identify motor functions needed for successful integration into the labor market. It was set up that motor performance in static lifting and static pulling corresponds to the requirements of professions that are taught in the rehabilitation centre for young people with mental disabilities.
Ethical aspects of the profession of social worker
Authors: Jedynak Witold
Published: July 2022

A set of moral standards plays an important role in social life, as it forms the basis for assessing the attitudes and behaviors of individuals. Ethics attempts to determine and resolve normative issues relating to the specific social situations. Thus provides a basis for establishing the rules of human functioning in the situation arising from a particular social or professional role. The purpose of this paper is to present some aspects of professional ethics of social workers affecting the standards of the profession. Secondary sources were used in preparation of this text, especially code of ethics of social workers and other axiological contents on the issues discussed. A social worker, whose activities are essentially social, performs many professional roles. Therefore, they should be guided by values and moral principles, arising from general ethics and specific standards contained in the code of ethics of the profession. Codified professional ethics helps a social worker in the proper performance of duties and is a reference point for resolving ethical dilemmas. Standards contained in the code of ethics uphold the dignity of the profession and at the same time indicate how the representatives of the profession should behave, and how they should not. The provisions of the code of ethics relate to the profession, relationships with coworkers, beneficiaries, employers and society. They include specific objectives and tasks of social work, understood as a practical human activity for people who need support and assistance in the fulfillment of basic needs and solving problems arising as a result of deprivation of those needs.
Features and factors of professional self-fulfillment of skilled people
Authors: Kokun Oleg M.
Published: July 2022

The objective tendencies of social development determine significantly increased attention to the problem of persons’ self-fulfillment. Lack of knowledge on this phenomenon dictates the need for its theoretical justification as well as for empirical studies. This paper presents the results of a research aimed at determination of features and factors of professional self-fulfillment of skilled people of different ages and professions.
Full-semester and time-compressed fluency disorders course: an evaluation of student perceptions of competence, satisfaction, and workload
Authors: DeVeney Shari L. , Teten Amy F. , Friehe Mary J.
Published: July 2022

This article addresses the effectiveness of a time-compressed four-week course format compared to a full-semester 16-week format for a graduate-level course.  Participants were 78 students enrolled in a speech-language pathology course, fluency disorders. No significant differences were noted for student competency self-perceptions.  However, time-compressed students reported significantly higher levels of course satisfaction and workload difficulty.
The physicochemical analysis and health benefits of fresh and branded honey produced in delta state, Nigeria
Authors: Edo Great Iruoghene , Onoharigho Favour Ogheneoruese , Emakpor ghenerume Lucky , Akpoghelie Patrick Othuke
Published: July 2022

This research is aimed to investigate and evaluate the physicochemical characteristic of different honey produced in Delta State, Nigeria, to confirm its economical and nutritional quality in comparison with the international standard. The quality of fresh and branded honey samples produced in Delta State was assessed using physicochemical and mineral analysis. Eight fresh honey (FHs) samples and eight branded honey (BHs) samples were collected from the Autonomous Province of Delta State, Nigeria. The tested parameters were pH, free acidity, electrical conductivity, color intensity, moisture, ash, proline, diastase, HMF, invertase, glucose, fructose, sucrose, lipid and mineral content. A qualitative test (Fiehe, Lund and Lugol) was performed to test the purity of honey. Both honey samples displayed good physicochemical properties. The concentration level of sugars was higher in the branded honey in comparison to fresh honey samples. The physicochemical parameters of fresh and branded honey were in concordance with the international standard.
Investigation of bovine coronavirus strain CV-315 cultural properties
Authors:   National University of Life and Environmental Sciences of Ukraine, 15 Heroyiv oborony str., Kyiv, 03041, Ukraine, Berezenko A. ,   Biotestlab LLC, 57а Volodymyrska str., Vasylkiv, Obukhiv district, Kyiv region, 08601, Ukraine, Vabishchevych F. ,   Biotestlab LLC, 57а Volodymyrska str., Vasylkiv, Obukhiv district, Kyiv region, 08601, Ukraine, Godovskyі O. ,   Biotestlab LLC, 57а Volodymyrska str., Vasylkiv, Obukhiv district, Kyiv region, 08601, Ukraine, Nedosekov V. ,   National University of Life and Environmental Sciences of Ukraine, 15 Heroyiv oborony str., Kyiv, 03041, Ukraine
Published: July 2022

The purpose of this study was to investigate the features of cultivation of bovine coronavirus strain CV-315 isolated in Ukraine from a calf with coronavirus infection and to select optimal methods of virus cultivation to obtain viral material with the highest possible titers of infectious activity in order to develop manufacturing technology of means of immunoprophylaxis and specific diagnostics. During the study, the influence of a number of factors on the accumulation of strain CV-315 was studied: the presence and concentration of trypsin in the nutrient medium, the effect of fetal bovine serum, the degree of cell culture monolayer during virus infection, also the virus dose, temperature and the term of cultivation. According to the results, it was established that bovine coronavirus strain CV-315 has the highest infectious activity when cultured for 72 hours before the manifestation of CPE of 70–80%, without the addition of trypsin and fetal bovine serum content of 2% at 37±0.5°C. It was also found that the optimal infective dose is 0.1–0.01 viral particles per cell for infection of the fully formed monolayer of MDBK cell culture. The obtained results will be used in the development of veterinary vaccines against bovine coronavirus.
Genetic structure of the Ukrainian water buffalo population by ISSR-PCR markers
Authors:   Institute of Animal Breeding and Genetics named after M. V. Zubets NAAS, 1 Pogrebnyaka str., Chubynske village, Boryspil district, Kyiv region, 08321, Ukraine, Mokhnachova N. B.
Published: July 2022

The study of intraspecific genetic diversity of cattle, including species of the genus Bubalus from the subfamily Bull, is important because of the reduction of biodiversity of farm animals. The basis of genetic diversity is its genetic component. The loss of native species and breeds of cattle is a real threat to the biosphere, as the resilience of natural ecosystems and agroecosystems is directly linked to their genetic ability to adapt to environmental conditions. Polymorphism of ISSR-markers of the Ukrainian population of water buffaloes (Bubalus bubalis) from the farm of “TASBIO” LLC (Chernihiv region) was analyzed in 66 animals selected for the study. Genomic DNA samples were isolated from venous blood with a standard set of reagents. Genotyping was performed using specific ISSR primers: (ACC)6G, (GAG)6C, (AG)9C, (CTC)6C, (AG)8CA, (AG)8CGand (GA)6CC. We determined the difference in spectra both by the number of amplicons, their lengths (number of nucleotides) and by their polymorphism. As a result of the study, all primers showed polymorphism of buffalo DNA regions. Amplicons were defined in the range from 200 bp up to 4000 bp. Analysis of ISSR spectra revealed 87 loci, of which 71 were polymorphic. (AG)8CA-marker was the least polymorphic (PIC=0.234), (CTC)6C the most polymorphic (PIC=0.389). Conservative loci were found in four ISSR markers: 6 in (AG)8CA marker, 5 in (AG)8CG, 4 in (GA)6CC, and 1 in (AG)9C. 67 species-specific loci were identified for the Ukrainian water buffalo population: 10 for (AG)9C, 3 loci for (ACC)6G, 4 for (GAG)6C, 7 for (CTC)6C, 15 for (AG)8CA, and 14 in (AG)8CG and (GA)6CC. The ISSR primers used are recommended for molecular genetic analysis of buffalo DNA polymorphism.
Usage of polyvinylalcohol and polyvinylpyrrolidone for preparion of thawed ejaculated boar sperm for fertilization by ICSI
Authors:   Institute of Animal Breeding and Genetics nd. a. M.V.Zubets of NAAS, Pogrebnyaka Str, 1, Chubynske, Kyiv Region, 08321, Ukraine, Lyzohub O. Ju.
Published: July 2022

The aim of the study was to explore the effect of PVP (polyvinylpyrrolidone) and PVA (polyvinyl alcohol) media on deconserved ejaculated boar sperm and their preparation for artificial insemination to optimize biotechnological approaches. The studies used ejaculated cryopreserved sperm of a boar of the Myrhorod breed Dnipro 641. Genetic material was stored in the Bank of Genetic Resources of Animals IABG nnamed after M.V. Zubets NAAS for eight years. The sperm suspension was thawed in a water bath at +37 °C for 5 min until completely thawed. Separation of sperm from cryopreservative agent and diluent was performed using the swim up method in Sp-TALP medium. After the presence of sperm in the 10.0% solution of PVP for 10 min, motility decreased by 68.2% (P < 0.05) and amounted to 3.4%, and after the next 10 min of incubation decreased to 1.4% (P <0.01), which is 10 times lower than the initial mobility. In 10.0% of PVA mobility after 10 min of incubation decreased by 37.4% (P <0.05) and amounted to 6.7%, and after 10 min decreased to 5.7% (P < 0.01), which is 1.8 times lower than the initial mobility. It was found that in the case of 10.0% of PVP solution ejaculated deconserved boar sperm lose motility by 86.9% (P <0.01) from the initial motility, which makes it impossible to select a suitable sperm for fertilization by ICSI (intracytoplasmic sperm injection). It is shown that 10.0% PVA solution can be used for immobilization of boar sperm, as it reduces motility by 46.7% (P <0.01) of the initial sperm motility. It is proved that the mobility in the case of incubation of deconserved ejaculated boar sperm in 5.0% PVA solution decreases only by 28.0% (P <0.05) from the initial, which is optimal when using cryopreserved boar sperm, material which are limited and convenient for the operator and safe for oocytes.
МАРКЕТИНГОВА СТРАТЕГІЯ ЯК ІНСТРУМЕНТ РЕАЛІЗАЦІЇ СТРАТЕГІЧНОГО ПЛАНУ РОЗВИТКУ ТЕРИТОРІАЛЬНИХ ГРОМАД
Authors: ОЛЕКСЮК Ганна , ХРОМ’ЯК Йосиф , ПОПАДИНЕЦЬ Назарій
Published: July 2022

Досліджено основні підходи щодо стратегічного планування в територіальних громадах України на основі окремих стратегічних планів їх розвитку у Волинській, Івано-Франківській, Львівській та Тернопільській областях. Визначено загальні тенденції стратегічного планування в територіальних громадах, окремі недосконалі підходи до формування основних, оперативних цілей та завдань стратегій.
Сьогодні виникла нова об’єктивна реальність – воєнні дії та відбудова країни після перемоги. Це виклик, наслідком якого є необхідність змінювати методичні підходи до комплексного економічного і просторового планування в територіальних громадах на основі прийнятого нового законодавства й нормативного регулювання. Обґрунтовано потребу у формуванні дієвого інструменту реалізації стратегій щодо застосування деталізованих механізмів досягнення цілей і виконання завдань запланованих сценаріїв і загального бачення розвитку громад. Запропоновано методологічний підхід до розробки маркетингових стратегій для територіальних громад як інструменту реалізації стратегічних планів їх розвитку, у тому числі з урахуванням змін, зумовлених вимогами післявоєнного часу. Управління територіальними громадами на засадах маркетингу, яке має відбуватися на основі оцінювання сприйняття товару «територіальна громада» різними цільовими групами (населенням, бізнесом, відвідувачами, інвесторами), буде більш ефективним при застосуванні особливостей функціонування кожної групи як відповідного споживчого сегмента послуг громади. Сформовано умовну схему, за якої територіальні громади можуть розробити і прийняти маркетингову стратегію як один з документів загального комплексу концептуального, просторового, стратегічного планування, що забезпечить більшу визначеність напрямів розвитку в розрізі цільових аудиторій, вказуючи на реальні інструменти, механізми, програми виконання завдань і заходів стратегічного розвитку територіальних громад у визначеному часі.
The Evolving Role of the Multidisciplinary Heart Team in Aortic Stenosis
Authors: Khan Sahoor , Shi William , Kaneko Tsuyoshi , Baron Suzanne J
Published: July 2022

Transcatheter aortic valve replacement has transformed the paradigm of care for patients with severe aortic stenosis (AS). With transcatheter aortic valve replacement now commercially approved for AS patients of all surgical risk, clinical decision-making regarding the initial mode of valve replacement (e.g. surgical versus transcatheter) and prosthesis type has become even more complex. The updated American College of Cardiology/American Heart Association and European Society of Cardiology/European Association for Cardio-Thoracic Surgery guidelines on valvular heart disease offer a strong foundation from which to address the nuances of the treatment of AS; however, there remain several clinical scenarios for which evidence and thus definitive societal recommendations are lacking. As such, the heart team continues to play an invaluable role in the management of the AS patient by combining available scientific evidence, expertise across disciplines, and the patient’s preferences to optimize individualized patient care and healthcare resource usage.
Territorial capital of Russian regions and its spatial organization
Authors:   Institute of Economics of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation, Suvorova Arina V.
Published: July 2022

Relevance. The new challenges that exacerbate long-standing issues stimulate the Russian economic system to evolve faster and to seek greater efficiency. One of the impediments to this process, however, is the inertness of the spatial organization of the national economy. There is a need for more detailed research on the characteristics of the national economic space for evidence-based policy-making in the sphere of spatial development. Research objective The study aims to describe the organization of Russia's economic space by focusing on the patterns of localization of its territorial capital. Data and methods. The study uses official statistical data on Russian regions provided by the Federal State Statistics Service (Rosstat) and a set of indicators of regional inequality. Methodologically, the study relies on the methods of spatial autocorrelation analysis and cartographic analysis. Results. It has been shown that there are significant regional disparities combined with the high level of polarization of the Russian space. There is a scarcity of asset concentration areas, which are mostly located in the country's western part, leaving the eastern part lagging behind and limiting its potential. The territories that are struggling the most are those devoid of resources and located remotely from the areas of asset concentration. The patterns of geographic distribution of gross regional product are to a great extent similar to the patterns of distribution of production capital, which may point to the existence of factors leading to regional divergence. The distribution of creative capital in Russia is far from optimal, which prevents it from becoming a major driver behind the country's economic growth. Conclusions. Policy-makers need to take into account the patterns of asset distribution in devising measures for enhancing territorial capital and setting priorities for the country's economic spatial development.
Smart territories as a driver for the transition to sustainable regional development and green economy
Authors:   Southern Federal University, Rostov-on-Don, Russian Federation, Nikitaeva Anastasia Y. , Chernova Olga A. ,   Southern Federal University, Rostov-on-Don, Russian Federation, Molapisi Lesego ,   Botswana Institute for Development Policy Analysis, Gaborone, Botswana
Published: July 2022

Relevance. Even though there is a general agreement regarding the importance of the transition to a green economy, this process still has a long way to go, which makes the research on the role of smart territories particularly relevant. Research objective. The study aims to describe the opportunities and areas of digital transformation of territories with a focus on the transition to a green economy. Data and methods. The research methods include content analysis, case study, mapping, and matrix analysis. The data sources were scientific articles presented in the Scopus database, materials from the Ministry of Finance and Economic Development, the Ministry of Mineral Resources, Green Technologies, and Energy Security, materials from the Central Bureau of Statistics of Botswana, the Botswana Energy Company. Results. Using the case of Botswana, the study showed that the establishment of a smart territory is the core mechanism of a transition to a green economy. Smart territories help regional governments to reach the sustainable development goals by using cutting-edge digital technologies. Conclusions. The article proposes a new approach to analyzing the transition to a green economy. This approach can also be applied to reconsider the composition and roles of the drivers of territorial development. The proposed methodology can be used to create a smart contour for the development of a given territory, taking into account the region’s industrial specialization, and to identify the most promising areas and "bottlenecks".
Assessment of the Leontiev productive matrix of the economic development model for Tyumen region (Russia)
Authors:   Tyumen Research Center SB RAS, Tyumen, Russian Federation, Tsibulsky Vladimir R. , Vazhenina Larisa V. ,   Tyumen Industrial University, Tyumen, Russian Federation, Solovyov Ilya G. ,   Tyumen Research Center SB RAS, Tyumen, Russian Federation,   Tyumen Industrial University, Tyumen, Russian Federation, Govorkov Denis A. ,   Tyumen Industrial University, Tyumen, Russian Federation,   Tyumen Research Center SB RAS, Tyumen, Russian Federation, Novikov Viktor P. ,   Tyumen Research Center SB RAS, Tyumen, Russian Federation
Published: July 2022

Relevance. Monitoring has always been an important part of the management of regional development. Recently, this task has been gaining currency due to the development of modern information technologies of data collection and processing, citizen-government interaction and digital modelling. The task of goal evaluation, that is, comparison of the actual results with the intended ones in different spheres, among other things, requires us to build and adjust the macro-economic model of regional development and in particular to update the input-output matrix based on the region’s statistical data. Research objective. The study aims to build a table of input-output balance for the south of Tyumen region (Russia) based on the statistical data of standardized economic indicators. Method and data. Two options for estimating the input-output matrix for Tyumen region are described. In the first option, a well-known method of adjustment of the reference input-output matrix for the priority economic sectors of Tyumen region is supplemented by the regularization of the resulting parameters according to the least squares method for the selected period. The second option is based on the aggregation of industries by subsystems based on the cost structure table of the same industries, but for the entire country, followed by the identification of the already aggregated matrix, without adjusting the result to the standard. Results. In the first option, we obtained a table of input-output balance for 2018. The table quite accurately reproduces the invoice structure of costs and consumption. The aggregated input-output matrix, taking regularization into account, reproduces the actual costs of the region for 2016-2018 with good approximation. In the second option, the distribution of the resulting direct costs coefficients over the years does not exceed 10%. Conclusions. The resulting estimates of the Leontiev input-output matrices meet the requirements of productivity and balance and can be used in benchmark problems for the analysis and forecasting of the economic development of Tyumen region. A variation of the functional scheme for assessing and analyzing the discrepancies between the declared and actual trajectories of the indicators based on the Leontiev matrix is proposed.