bluuebunny/crossref_metadata_2025 huggingface dataset:
Principal results of Borrelia genotyping in Russia
Authors: Korenberg E. I. , Nefedova V. V. , Fadeyeva I. A. , Gorelova N. B.
Published: April 2021

Borrelia garinii, B. afzelii (which are widespread and epidemiologically significant), B. burgdorferi s.s., B. valaisiana, B. lusi- tania, B. spilmani circulate in Russia and neighboring countries. By sequences of the rrf (5S).rrl (23S) regions of 139 primary iso- lates B. afzelii were determined seven genetic variants belonged to the subgroup VS461, and three — to the subgroup NT28. Seven alleles variants was find by sequences 246—337 pb of p66 gen from 45 isolates B. afzelii.
Clinical manifestation and differential diagnosis of Ixodes tick-borne borrelioses
Authors: Loukashova L. V. , Lepyokhin A. V. , Zhoukova N. G. , Dobkina M. N. , Kiyutsina T. A. , Odintsova L. N. , Pirogova N. P. , Karpova M. R.
Published: April 2021

The article gives up-to-date information on clinical manifestation and differential diagnosis of Ixodes tick-borne borrelioses.
The scientific-practical conference «How to avoid physician's mistakes»
Authors: Bodrova T. N.
Published: April 2021

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Prognostic importance of dispersion of interval Q-T electrocardiograms in patients with myocardial infarction
Authors: Teplyakov A. T. , Kamaev D. Yu. , Kalyuzhin V. V. , Pushnikova Ye. Yu. , Kalyuzhina Ye. V. , Stepacheva T. A.
Published: April 2021

The aim of research was comparison of prognostic importance of various indexs non-homogeneousness of processes repolari-zations of heart ventricles registered in acute and subacute periods of myocardial infarction (MI). The retrospective analysis of med-ical histories has allowed to determine dynamics of dispersion of intervals Q-T, Q-Ta and R-Tm in groups of patients with fa-vourable (n = 125) and lethal (n = 250) outcome. The best prognostic importance concerning fatal cardial events have indexs cor-rected on frequency of cardiac rhythm. Most important and independent predictor of intrahospital cardial deaths of the patients with MI is a dispersion of the corrected interval R-Tm, exceeding 80 мс1/2 in the first 6 hours after hospitalization.
Diagnosis and choice of the surgical treatment volume in patients with nodular disease of the thyroid gland
Authors: Zherlov G. K. , Zykov D. V. , Rezantseva N. P. , Karpovich A. V. , Zherlova T. G.
Published: April 2021

The aim of the study was develop the treatment –diagnosis algorithm in nodal diseases of the thyroid gland. Analysis of diagnosis and treatment procedures in 252 patients with nodal disease of the thyroid gland was performed. The differential diagnosis algorithm of patients’ examination which included preoperative ultrasound study (US), fine-needle aspiration biopsy, laser Doppler flowmetry (LDF) and also perioperative US and LDF allowed to reliably determine character of the thyroid gland lesion, its morphological type in 91.7% of cases and choose the adequate volume of surgical treatment.
Functional activity of gdТ-cells in atopic dermatitis
Authors: Chourina Ye. G. , Klimov V. V.
Published: April 2021

Functional activity of gdТ-cells in atopic dermatitis (AD) in dependence on the disease stage and concomitant pathology character was studied. We investigated 86 patients: 54 women and 32 men aged 17—50 years. AD patients revealed significant insufficiency of the cell immunity, the most marked of them being in gdТ-cells.The level of CD8aa did not differ practically but number of CD8ab-cells and NK-cells was decreased. Clinically, it manifested in continuously recurrent course of the disease with high risk of complications with joiningbacterial and viral infections.
The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions
Authors: Goldberg Ye. D. , Dygai A. M. , Zhdanov V. V.
Published: April 2021

The development of hemopoietic tissue hypoplasia and recovery of hemopoietic dynamics in addition to the direct suppressive effect of toxic agents on hemopoietic cells are mainly due to the character of hemopoietic disregulation were shown on different models of myelosuppressions (irradiation, injecting cytostatic drugs having different action mechanisms). At the same time, compensatory changes of blood system and underlying mechanisms are mainly non-specific and of the same type. Creation of reparative processes in the hemopoietic tissue is significantly by bone marrow stromal cells thanks to chemioand radioresistance of their precursors (mesenchimal stem cells).
Sergei Vladimirovich Myasoyedov
Authors: Ryzhov A. I. , Mendrina G. I. , Logvinov S. V.
Published: April 2021

The biography and main directions of scientific activity of professor, chief of histology and emdryology chair of the Tomsk university (since 1931 TMI) S.V. Myasoyedov are presented. Recollections of the his contemporaries and pupils are given. Historical role of S.V. Myasoyedov in the formation of science is defined.
Dicvertase potential for the treatment of osteoarthrosis in the geriatric practice
Authors: Gridneva T. D. , Dobrynina A. L. , Plotnikov M. B. , Oudut V. V.
Published: April 2021

Complex treatment of aged and old patients ( n = 60) suffering from deforming osteoarthrosis complicated with reactive synovitis in combination with associated pathology of cardiovascular system is studied. Natural antioxidant dicvertase introduced by ultrasonic waves was used. Positive combined action of ultraphonophoresis by dicvertase was revealed which resulted in lowering pain syndrome, increasing motions range in the affected joint, normalizing of immunity status which allows to broaden indications for the treatment of these patients by lowering the risk of development of pathologic response of the organism on the treatment and facilitates lowering drug loading on patients.
Standardization of the dry extract having anti-inflammatory and analgesic properties from the leaves Arctium tomentosum Mill
Authors: Dudko V. V. , Khoruzhaya T. G. , Pashinsky V. G. , Povetyeva T. N. , Novozheyeva T. P. , Korshounova N. Ye.
Published: April 2021

The work is devoted to the problems of obtaining dry and liquid extracts from the leaves of Arctium tomentosum Mill. on 25, 40, and 70% ethanol solution and their standardization. Optimal content of tablet drug form based on the dry extract on 70% ethanol is offered. Animal experiments revealed anti-exudative activity of the dry extract of А rctium tomentosum Mill.on 70, 40 и 25% of ethanol solution, analgesic activity of the dry extract on 70 and 25% of ethanol solution, wound healing action of the dry extract on 25% of ethanol solution .
Sоme aspects of attitude at patients with ulcer disease to physician’s recommendation
Authors: Anikina Ye. B. , Vavilov A. M.
Published: April 2021

The рurpose of this work is the study of compliance of patients with peptic ulcer (PU). The results of the examination of 144 patients aging 18—82 with PU of different localization have been generalized.. The compliance of women with PU at all the phases of the disease was higher than that of men. The adequate attitude of patients to physician’s recommendations is a necessary condition for the improvement of treatment results.
Body experience in the east-slavonic culture tradition
Authors: Kirilenko Ye. I.
Published: April 2021

In the modern science, the body is an object of interest not only to the natural science and medicine, but also the humanities. Of special interest, in particular, for the medical discourse, is the ethnic body experience. The paper reveals features of the body experience in the east-slavonic culture from the analysis of the mythological tradition. This experience is characterized by the pronounced interest and ambivalent attitude to the body’s life, natural body standards; and emotional intensity. The experience of the social body is of highest priority in the culture.
Phenomenology and classification of food behavior disturbances (literature review, part II)
Authors: Romatsky V. V. , Syomin I. R.
Published: April 2021

Literature data on the epidemiological character concerning the occurrence of food behavior disturbances in the historical aspect are presented. Current diagnostic signs of this form of pathology are described, criteria of their improvement are discussed. The very high percentage of comorbidity of food behavior disturbances with psychic and somatic disorders is noticed by Russianand foreign authors.
Postoperative rehabilitation of patients with colloidal nodular goiter
Authors: Zherlov G. K. , Rezantseva N. P. , Zykov D. V. , Karpovich A. V. , Zherlova T. G.
Published: April 2021

The new method for the rehabilitation of patients operated on thyroid gland because of the colloidal nodular goiter has been suggested. The method includes the prescription of non-steroid anti-inflammatory nimesulide drug and microwaves during the earlier postoperative period in combination with the hormonal status correction. This rehabilitation method results in sooner wound reparation, shorter period of physical disability, and better life quality of patients comparing to traditional postoperative management.
Ethic problems of public health service
Authors: Chernov A. S. , Soloviyova S. A. , Borzunova Ye. M.
Published: April 2021

The paper is devoted to ethic problems of public health service during second-generation epidemiological AIDS inspections. The necessity of ethic expertise of any AIDS investigation is justified. The experience of organization of an ethic committee in the USA in a health care facility is described.
Body of suffering: philosophic-anthropological interpretation
Authors: Tischenko P. D.
Published: April 2021

The author’s concept of anthropology of suffering and embodiment of biopower is discussed in the context of bioethical prob- lems. Basic prerequisites for division of human totality into soul (selfhood) and body are described with reference to philosophic- anthropological categories of suffering, salvation, and death.
Limits on Patient Responsibility
Authors: Kelley M. .
Published: April 2021

As we debate the nature and extent of patient responsibility it is important to keep in mind the reasons for giving a relatively minimal role to patient responsibility in medical ethics. It is argued that the medical profession ought to be characterized by two moral asymmetries: even if some degree of responsible behavior from patients is called for, placing the dominant emphasis on pro- fessional responsibility over patient responsibility is largely correct; insofar as we do want to encourage an increase in patient re- sponsibility, we have good reasons to emphasize prospective rather than retrospective notions of responsibility in clinical practice. Concerns about patient vulnerability along with the determined factors in disease leave little room for blame at the bedside. These two asymmetries generate normative limits on any positive account of patient responsibility.
Possibilities of physical-chemical regulation of stem cells' pool
Authors: Khlusov I. A.
Published: April 2021

Modulating influence of electric impulses, visible light, some microelements is studied in parameters which are near to physio-logic ones on life activity of progenitor and mature cells of blood system in vitro and in situ. Content of granulocyte and fibroblastoid colony-forming units, concentration of colony-stimulating and colony-inhibiting activities, their concentration were determined , myelograms and morphologic signs of myelocariocytes apoptosis and necrosis were scored, saturation by chrom ions of peripheral blood erythrocytes was studied in mice bone marrow. The results showed that cell effects of physical-chemical influ-ences are small specific. Nevertheless, one may perform both positive and negative regulating influence on life activity of stromal precursors in dependence of energy density and stimulus concentration . The effect is due not only by direct but mediated reactions regulating direction and intensity of metabolic intracellular processes. It is suggested that one of target cells capable of change in-crease program of hemopoietic and stromal cells-progenitors of bone marrow in dependence of physical stimulus strength are lym-phocytes.
Effect of ultra-disperse powder оf zirconate-titanate lead on morphological and functional status of kidney studied experimentally
Authors: Shevtsova N. M. , Novitsky V. V. , Stepovaya Ye. A. , Nizkodubova S. V.
Published: April 2021

Rat experiments revealed that daily inhalation of ultra-disperse powder (UDP) оf zirconate-titanate lead in a dose of 15 mg/m3 re-sult in increased contents of single element of UPD in kidneys and cause changes of morphological and functional status of the or-gan. According to accumulation degree in kidneys, the studied chemical elements are situated in the following sequence: Pb > Ti > Cr > Mn. The presented results are indicative of moderately expressed toxic effect of UDP of circonate-titanate lead on morphological and functional status of rat's kidney, been subjected to its inhalation influence.
The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats
Authors: Gousakova S. V.
Published: April 2021

Influence of cytoskeleton modulation by Colchicine and Cytochalasine B on contractile reactions of smooth muscle segments of rat's aorta caused by physiologically active substances, the membrane's depolarization and cells' striction was investigated by mechanographical method. Microtubules and actinic elements of the cytoskeleton were established to participate in the development of hyper-potassic and phenylephrine -induced contractions as well as in the smooth muscle relaxation induced by cAMP. Cytochalasine B suppresses both kinds of aortic smooth muscle contractions more effectively than Colchicine. Contractile reactions at isoosmotic striction are suppressed only by Cytochalasine. Efficacy of cAMP signal system operating depends on actinic cyto-skeleton integrity.
Оценка изменений гемодинамики при вентрикуло-коронарной перфузии
Authors: Tolpekin V. Ye. , Shumakov D. V. , Gasanov E. K. , Saitgareyev R. Sh. , Mukha A. V. , Goncharov P. N. , Baikov A. N.
Published: April 2021

One of the most popular methods of myocardial revascularization is the surgery of coronary arteries. Our research results revealed that adequate myocardial blood flow is provided by hemo-perfusion from the left ventricle to coronary arter-ies.
Activity of blood kallikrein-kinin and renin-angiotensin systemsin newborns with hypoxic-ishaemic encephalopathy
Authors: Soukhanova G. A. , Kondratyeva Ye. I. , Gunbina T. Ye. , Gorev V. V. , Khlynina T. N.
Published: April 2021

Oxygen insufficiency in newborns is associated with disturbed vascular tone, which are regulated by kallikrein-kinin (KKS) and renin-angiotensin systems (RAS).Important index of hemodynamic disturbances is the activity of kallikrein, of angiotensin-converting enzyme (ACE) and also inhibitors of proteinases: α1-proteinase inhibitor and α2-macroglobulin. In hypoxic-ischemic encephalopathy of mature newborns and children of the I, II premature degrees , blood KKS activity is increased in comparison with RAS. Decreased activity of α1-proteinase inhibitor is seen in 46% of premature infants of II degree which usually leads to chronic pathologic process. The increased activity of ACE is important for preventing hemodynamic disturbances.
Characterization of mortality causes in Tomsk Region
Authors: Adamyan A. T. , Kladov S. Yu.
Published: April 2021

The paper analyzes main causes of population mortality in Tomsk Region for 2002-2007 taking into account nosology. It is found that in some regions (Shegarskii, Molchanovskii, Krivosheinskii, and Asinovskii) the death rate exceeds the average level. There is a tendency to decrease of the death rate in Tomsk Region. Measures conducing to health are proposed.
Factors determining working longevity of medical professionals and ways ofcorrection within the framework of the National Project «Health»
Authors: Babanov S. A.
Published: April 2021

The paper studies the prevalence of nicotine and alcohol addiction and the attitude to work among doctors, medical professionals, and students. Possible methods of prevention of nicotine addiction are described.
Influence of combined antihypertensive therapy on plasmatic,vascular-thrombocytic hemostasis and lipid peroxidation in patientswith metabolic syndrome and arterial hypertension
Authors: Krasnova N. M. , Bushkova E. A.
Published: April 2021

The impact of antihypertensive therapy with the angiotensin-converting enzyme inhibitor enalapril (enap) and with enalapril in combination with the long-acting calcium channel blocker verapamil SR (isoptin SR) on changes of plasmatic, vascular-thrombocytic hemostasis and lipid peroxidation in patients with metabolic syndrome and arterial hypertension was studied. Combined therapy with enalapril and verapamil significantly reduces the fasting glucose and glycated hemoglobin concentrations, the aggregation activity of thrombocytes in the patient's blood, inhibits the lipid peroxidation, increases the level of high-density lipoprotein cholesterol, and decreases the coefficient of atherogenecity. Combined therapy with enalapril and verapamil SR can be recommended for treatment of arterial hypertension in patients with metabolic syndrome.
Heparprotective effect of Bergenia crassifolia extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid
Authors: Shutov D. V.
Published: April 2021

The object of this research was to study rat liver bioenergetics at pathology caused by inhibition of β-oxidation of fatty acids against the background of 4-pentenoic acid injection and at silymarin and Bergenia crassifolia extract therapy. The experiment was conducted with 50 nonpedigreed male rats. The functional state of the energy production system was estimated by the polarogaphic method from the rate of oxygen consumption in different Chans metabolic states. At silymarin therapy, increase was observed in the oxidative phosphorylation coupling in all metabolic states. The Bergenia crassifolia extract favored normalization of energy production parameters in rat liver mitochondria more efficiently than silymarint did.
Etiological structure of meningeal and meningoencephalitic tick-borne infections in children of Kemerovo Region
Authors: Pinevich O. S. , Poponnikova T. V. , Bedareva T. Yu.
Published: April 2021

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Epidemiological stroke research in Seversk, Tomsk region
Authors: Alifirova V. M. , Antukhova O. M.
Published: April 2021

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Capabilities of laboratory diagnostics and monitoring in neonatal nephrology
Authors: Suvorova A. V. , Zenchenko O. A.
Published: April 2021

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Modern therapy of multiple myeloma
Authors: Votyakova O. M.
Published: April 2021

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Value of β2-мicroglobulin in prediction of current and choice of therapy of chronic lymphoid leukosis
Authors: Zagoskina T. P. , Kulikova M. M. , Malykh O. V.
Published: April 2021

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Example of successful therapy whith nilotinib at resistant to interferon and glivec patient with chronic phase of Ph-positive chronic myeloid leucosis
Authors: Gusarova G. A. , Afanasiyeva N. A.
Published: April 2021

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Interesting case of syphilitic lesion of stomach
Authors: Kovalyova L. B. , Beloborodova E. I. , Pesterev P. N.
Published: April 2021

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Phenomenon of medical culturePart 1. Methodological aspect of medical culture
Authors: Khlystova N. A.
Published: April 2021

Medical activity, which always includes the necessity to solve a system of logical, gnoseological, axiological, and praxiological problems associated with the process of diagnostics and treatment of a patient, can be successful only with high culture of a specialist. It is a moral obligation of a medical practician to become a man of culture. Based on a systematic approach, the paper presents medical culture as a specific subsystem of general culture, whose mastering starts in childhood, develops in university, and continues for the whole life, demanding colossal mental energies. In Part 1, the emphasis is at methodological culture of a doctor, and logics of description, definition, and explanation of a studied object or process is presented.
Clinical and morphological peculiarities of different formsof ovarian apoplexy
Authors: Kokh L. I. , Sodnomova N. V. , Kirillov A. V.
Published: April 2021

With the aim of revealing clinical-and-morphological peculiarities of different forms of ovarian apoplexy, there has been an analysis carried out covering 303 case histories of the Gynaecology Department of the Regional Clinical Hospital, Tomsk for the period from 2000 to 2005. It has been established that the ovarian apoplexy is characteristic of young women having in past history a gynaecological pathology and an adhesive process in pelvis minor. The results of complex diagnostics with a subsequent morphological investigation reveal the fact that instead of ovarian apoplexy, it is more often a corpus luteum rupture and follicular cyst rupture that actually take place.
Mutual correlation of excited potentials of the brainwith the level of special physical training of football-players
Authors: Kapilevich L. V. , Zamoulina Ye. V.
Published: April 2021

Decreased amplitude and increased latency of visual and cognitive excited potentials were revealed in football-players in the stage of prima ry special sports training in the first year of their training process. In the second training year, this amplitude is increased and latency is decreased. Forming special physical preparing of the football-players in the stage of primary sports specialization is mutually correlated with functional changes in the central nervous system which manifested in decreased latent period and increased amplitude of excited potentials of the brain.
Molecular medicine and viral infections: modern view on the problemand strategy of interrelations
Authors: Ryazantseva N. V.
Published: April 2021

The lecture presents basic directions of molecular medicine development. Special attention is devoted to prior direction of identification of molecular and genetic markers of predisposition to chronic course of socially important viral infections, development of molecular basis for personalized therapy and outcome prognosis of interrelations between an infect and a human. Analysis of literature data concerning the discussed prob lem and also the results of proper investigations are presented.
Determination of elastic characteristics of cataractously changed lenses in the experiment
Authors: Kokova A. A.
Published: April 2021

The purpose of the investigation is the definition of numeral meanings of the Young’s module on the central part of cataract in vitro. The experiment was carried out by the method of penetration on 108 lenses of a human eye with the help of the developed original device. It is revealed that the area of resilience display is within small limits of unit strain. The Young’s module is within 2 MPa to 6 MPa and depends on the density of a lens nucleus (III—V) according to Buratto.
Phenomenon of medical culture Part 2. World outlook component of medical culture
Authors: Khlystova N. A.
Published: April 2021

Medical activity, which always includes the necessity to solve a system of logical, gnoseological, axiological, and praxiological problems as sociated with the process of diagnostics and treatment of a patient, can be successful only with high culture of a specialist. It is a moral obligation of a medical practician to become a man of culture. Based on a systematic approach, the paper presents medical culture as a specific subsystem of general culture, whose mastering starts in childhood, develops in university, and continues for the whole life, demanding colossal mental ener gies. Part 2 reveals the content of world outlook and philosophic-anthropological aspects of medical culture, grounds the necessity of the revise of the existing anthropological paradigm.
Death rate of the population of Tomsk Region for last two decades and measures on its decrease
Authors: Oleinichenko V. F. , Mendrina G. I. , Khlynin S. M. , Kalinkin D. Ye. , Nesvetailo N. Ya. , Takhauov R. M. , Karpov A. B. , Varlakov M. A.
Published: April 2021

Mid-annual indicators of the general death rate during the period with 1996 on 2000 of on Tomsk Region, as well as on to the Siberian Federal district, and as a whole across the Russian Federation practically did not differ from similar indicators during the period with 1992 on 1996 of (their distinctions are doubtful — p > 0,05). Despite some decrease in rates of growth of death rate in 2001—2005 of, its level remains high — in 2001 it was 13,3, and in 2005 — 14,5 on 1000 population. The greatest number of people dies of illnesses of system of blood circulation, accidents, poisonings and traumas, new growths. Relative density died of the specified reasons from number of all died made in 2005 according to — 46,3%, 15,7% and 14,0%. Especially attracts attention growth of death rate of the population of area in 2,6 times in 2005 in comparison with 2001 from the reasons connected with the use of alcohol growth of death rate from the given reasons at persons of able-bodied age is More expressed. Mid-annual level of parent death rate in 2001—2005 of has decreased in comparison with 1996—2000 of on 29,2%. Strengthening of health is spent to areas not only women and children, but also all population the big complex of the actions directed on decrease of parent and infantile death rate, preventive maintenance of illnesses of system of blood circulation, etc.
The beneficial effect of reflexotherapy on the dynamic results of the patient’s life-quality in psychotherapeutic permanent establishment
Authors: Matuskova T. D. , Maslova N. N. , Fadeyeva O. V.
Published: April 2021

The article presents the dynamic results of the life-quality parameters in psychiatric patients before and after combined pharmaco- and reflexotherapy. We studied, assessed the clinical data and concluded better responses to psychosocial status therapies. Life quality assessments with the average overall population clinical data were also compared.
Particular features of osteopenic syndrome in patients with type 1 diabetes mellitus
Authors: Tonkikh O. S. , Zavadovskaya V. D. , Kravets Ye. B. , Kilina O. Yu. , Shoulga O. S. , Zorkaltseva O. P.
Published: April 2021

In this article the results of ultrasound osteometry in patients with type 1 diabetes mellitus are discussed. The aim of the research was to estimate the index of bone mineral density in adult patients considering the severity, duration of the disease, age of the onset of the disease, sex, age and body weight of the patients. The leading factors which influence bone mineral density in patients with type 1 diabetes mellitus are determined.
Effect of combined treatment on indices of liver venous blood flow in chronic opisthorchosis patients
Authors: Poddubnaya O. A. , Levitsky Ye. F. , Lyapunova I. Yu.
Published: April 2021

At chronic opisthorchosis, disorders of venous blood flow in liver are observed in color Doppler liver mapping. To improve venous blood flow indices and the functional state of the hepatobiliary system as a whole, combined treatment should include factors not only ensuring the antiparasitic, antiphlogistic, and cholagogic effect, but also improving liver hemodynamics. This problem can be solved by combination of measures including morning exercises, pine baths, intake of cholagogic herbs with the following transversal galvanization in the epigastric region, and background x-ray radiation.
Laboratory diagnostics at various groups of the population of Western Siberia south at thyroid gland pathology
Authors: Appelgans T. V. , Maklakova T. P.
Published: April 2021

The indigenous population of Mountainous Altai and the slavic population of Kuzbas Region with a thyroid gland pathology is surveyed. Prognostic algorithms of an estimation of peripheric action of hormones of a thyroid gland are made. Algorithms of inspection of patients with a diffusive struma can be recommended for practical use. For monitoring of an autoimmune pathology of a thyroid gland the estimation of a quantitative parity of a thyritropic hormone, an α2-macroglobulins and IL-6 in blood serum has prognostic value.
Effect of Kumasid medication on functional condition of rat’s main organs and systems
Authors: Belousov M. V. , Novozheyeva T. P. , Akhmedzhanov R. R. , Yusubov M. S. , Guryev A. M. , Novitskaya L. N. , Aminin D. L. , Stonik V. A.
Published: April 2021

An investigation of Kumazid medication influence on functional condition of experimental animal main organs and and systems, that were subjected to intragastric injection during three monthes, was made. It was determined that the Kumasid medication dosed 1—100 mkg/kg administrated to rats intragastically during three monthes doesn’t change internal conditions of lab animals.
Activity lipid peroxidation and glutathione systems of lymphocytes blood in patients with diffusive toxic struma
Authors: Urazova O. I. , Kravets Ye. B. , Novitsky V. V. , Rogalyova A. V. , Vasil’yeva O. A. , Kuznetsova V. N. , Nedosekova Yu. V.
Published: April 2021

In this article results of research of some parameters of oxidizing metabolism in lymphocytes blood in patients with verified diffusive toxic struma (DTS) of a various degree of an expressiveness are represented. Is shown, that for the patients with DTS activity the lipid peroxidation in lymphocytes is saved in norm limits. Thus the tags of disbalance of cell glutathione system antioxidative protection are scoredat.
The vascular channel of the axial flap and the host bed at the earliest period after restricted (not free) transposition
Authors: Semichev Ye. V. , Malinovskaya I. S. , Sinichev D. N.
Published: April 2021

In order to investigate the vascular channel change of the flap and vascular bond formation dynamics in the zone of flap-recipient (host) bed after transposition we worked out an experimental model with different variants of vascular pedicle flap preparation (intact pedicle flap, periarterial, perivenous and combined sympathectomy). The vascular channel was investigated with the help of clinical evaluation and investigation of anatomical macro-micro specimen. Clinical-anatomical finding demonstrates abnormal operation of microcirculatory flap channel after all kinds of vascular wall denervation. It was found out that in any variants of flap transposition conduction, the flap lifting and crippling of surrounding tissues causes unavoidable loss of additional (collateral) blood supply sources and disorder of lymph venous outflow. Conduction of pedicle flap sympathectomy in different variants causes additional abnormalities during integration of complicated tissue complex. Preservation of adventitious membrane of arterial vessels creates the most favorable conditions for flap integration and adaptation.
Treatment of patients with afterburn hypertrophic and keloid cicatrices
Authors: Kovalevsky A. A. , Fedotov V. K. , Pilipenko P. G. , Dolgikh V. T.
Published: April 2021

To improve the results of conservative treatment of patients with afterburn hypertrophic and keloid cicatrices, 245 patients up to 65 years old having afterburn cicatrices of various area and localization have been examined and treated. In 153 patients, cicatrices were treated using traditional medicines (1% hydrocortisone ointment or Kontraktubex gel), while 92 patients were treated by phonophoresis with verapamil ointment. Clinical-morphological investigations have shown that in patients treated by phonophoresis with verapamil ointment the earlier structural maturation of cicatrix, normalization of pain sensitivity, and more complete removal of afterburn contracture were observed.
Difficulties in differencial diagnosis of Herpes simplex encephalitis and tumor cerebri
Authors: Dekonenko Ye. P.
Published: April 2021

Herpes encephalitis (HE) often proceeds in the form of focal inflammatory cerebral affection resembling an abscess or tumor of the corresponding localization. Differential diagnosis of HE may be difficult, forcing diagnostics with other processes bounding the space. Case histories of four patients, in whom encephalitis foci were similar to brain-growth, are presented. Two patients were operated for removal of necrotic formations. Difficulties of diagnostics and ways to overcome them are discussed.
Clinical-constitutional features of patients with ischemic stroke at toxic encephalopathy
Authors: Kladova Ye. A.
Published: April 2021

Neurological, psychological, anthropological, biochemical, and neurovisualization statuses have been studied in 200 alcohol abused patients after acute cerebrovascular pathology. It is shown that the groups of alcohol-abused patients show a more serious clinical pattern compared to the groups of patients free of alcohol dependence.
Doppler inspection results of first year infants with hydrocephalic syndrome of hypoxic-ischemic genesis
Authors: Kovalenko A. V. , Karkashina O. V. , Kovalkov K. A.
Published: April 2021

Case monitoring of 105 infants from 1 to 12 months with 1, 2 degrees cerebral ischemia was realized. Clinical, clinical-neurovisual signs of hydrocephalic syndrome were observed in 57 patients of the first group. For 48 infants of the second group there were only neurosonographic signs of cerebrum liquor spaces dilatation. Transcranial Doppler investigation was included into case monitoring. Indices of cerebral hemodynamics determining clinical finding of intracranial hypertension were established. Principal mechanisms of cerebral hemodynamics changing under hydrocephalic syndrome for infants of the first year were found. Stable characteristics pointing to intracranial hypertension regardless of clinical finding are shown.
Cognitive disorders in the patients with traumatic intracranial hematomas after the operation
Authors: Kurilina L. R.
Published: April 2021

The purpose of the study was to study cognitive disorders in the patients with traumatic intracranial hematomas after the operation. 150 operated patients were neuropsychologically assessed with qualitative and quantitative analysis. Differently expressed cognitive disorders were revealed in the most of (95%) patients. The patients with hematomas combined with cerebral foci of crushing had more severe cognitive deficit than the patients with ‘isolated’ hematomas. Localization of cerebral lesions had the principal effect on the features and expressiveness of cognitive impairment in the patients with hematomas combined with foci of crushing. The duration of the interval from the moment of trauma till operation had the most significant influence on the severity and the features of cognitive disorders in patients with isolated hematomas. The restoration of cognitive functions depended on severity of cognitive disorders in acute stage.
Brain stem’s damage in patients with acoustic neuromas and subtentorial meningiomas according to Proton Magnetic Resonance Spectroscopy
Authors: Moisak G. I. , Olyushin V. Ye. , Fokin V. A. , Okolzin A. V. , Maslova L. N.
Published: April 2021

Extracerebral tumors of posterior fossa often lead to dysfunction of the brain stem, however the degree of brain stem’s damage is determined most often on the basis clinical data only. Magnetic Resonance Spectroscopy (MRS) allows to study biochemical processes and determine chemical content of the cerebral tissues noninvasively. Changes in brain stem’s perifocal zone in patients with acoustic neuromas and subtentorial meningiomas have been studied. Basic metabolite’s level’s analysis of N-acetyl-asparatate (NAA), creatine, choline and lactate have been conducted. Changes in brain stem’s metabolism depend on duration of the disease and the conditions of the patient on admission have been revealed. However the change in metabolite’s level and their role in the brain in case of pathology and in normal conditions need further investigations.
A clinical picture and treatment optimization of acute forms of tick-born encephalitis
Authors: Nadezhdina M. V. , Toporkova M. G. , Gurary N. M. , Makhneva N. A.
Published: April 2021

A comparative clinical and serological analysis of two groups compatible by sex, age and clinical forms of acute tick-born encephalitis was conducted among 68 patients with confirmed immune enzyme method. All patients received a single injection of high titrating Russian human tick-borne encephalitis immunoglobulin by the doze varying on the patient’s weight and particular decease. All patients received symptomatic therapy as well. There were 33 patients in the group II who have been taking anaferon during two weeks since the acute period. The patients of the groups I and II didn’t have any robust alteration of the feverish period duration and cerebrospinal fluid sanitation but it was discovered that the patients of the group II with focal form had reveal predominance of IgM titer on the second week of the disease development comparing with the same indicators among the patients of the group I with focal form. The findings show the possibility to recommend anaferon for complex treatment of the patients with tick-born encephalitis in acute period.
Clinical determinants of neurologic worsening in various stroke subtypes
Authors: Oleksyuk N. V. , Zudin V. V. , Sychyova M. A. , Kouryachenko Yu. T.
Published: April 2021

With the purpose of clinical determinants definition of neurological deterioration in patients with an ischemic stroke and its prognostic value, the retrospective analysis of case records of 253 patients with first in a life stroke was carried out and the estimation of neurological deterioration of early period of an stroke was performed.
The system approach in the estimation of arterio-venous correlation under hypertensive encephalopathy
Authors: Belova L. A. , Mashin V. V. , Belov V. G. , Gavrilyuck O. V.
Published: April 2021

System approach was used to determine arterio-venous correlation under hypertensive encephalopathy (HE). 250 patients with HE I—III and 30 controls matched for age and sex were examined. The clinical, ultrasonic diagnostics and quality of life (QL) index were applied. By means of ultrasonic diagnostics it was shown that in the process of HE development and progression the changes on all structural functional levels of cerebral vascular system occur. The QL analysis depending on the HE stage shown that as the disease progresses the physical constituent of health increases and the mental constituent of health decreases. In the group of patients with venous discirculation of the blood pain barrier was decreased, physical and mental health constituent were lowed.
To a question on crisis of social hygiene and evolution of concept of public health services
Authors: Vasilyev I. V. , Kalinichenko A. V.
Published: April 2021

Change of political and economic conditions should change a subject and methods of social study essentially. In postreorganization Russia the purposes of the state, methods and forms of the government, a subject and methods of a science have changed «Social hygiene» Were transformed unsystematically and till today's time are not certain. This circumstance has caused crisis of social hygiene as sciences. It is necessary to define a subject and methods of a science «Public health and public health services» on the basis of the right.
Haemocorrection in patients with malignant cerebral tumors
Authors: Seliverstov R. Yu. , Olyushin V. Ye. , Shatrov V. A. , Gurchin A. F. , Gaydayenko K. P.
Published: April 2021

The goal of the research was studying the clinical-laboratory manifestations of toxemic and complex immune syndromes in patients with malignant cerebral tumors, and also studying the possibilities of correction of such syndromes by means of the programs for infusion-desintoxication therapy in combination with plasmapheresis. Basic biochemical substrates of toxemia and complex immune syndrome are oligopeptides, substances of nonprotein nature (of high, low and average molecular weight) and circulating immune complexes. Plasmapheresis provides for their excretion, which allows to reduce the degree of autoimmune aggression and toxemia effectively. Application of haemodilution and preliminary-prepared autohaemocomponents for compensation of blood loss at surgical interventions, promotes for decrease of toxemia manifestations and complex immune syndrome in the nearest post-surgery term.
The results of combined immunotherapy in integrated treatment of patients with malignant brain glioma
Authors: Stupak V. V. , Chernykh Ye. R. , Pendyurin I. V. , Leplina O. Yu. , Mishinov S. V.
Published: April 2021

The problem of search and development of new approaches to integrated treatment of patients with malignant brain glioma remain one of the most urgent issues for contemporary neurosurgery and neurooncology. In spite of the applied efforts the results of a complex therapy for malignant glioma, especially for glioblastoma, are utterly unsatisfactory. Immunotherapy is one of the directions searching for a generation of cytotoxic cells able to lyse the tumor. Combination of various immunotherapeutic approaches is regarded the most perspective way. Since 1999 Neurosurgical Clinic of Novosibirsk Research Institute of Traumatology and Orthopaedics was carrying out clinical trials of combined immunotherapy within complex therapy of patients with malignant brain glioma in compliance with two protocols.
Depression, anxiety and blood serotonin in patients with multiple sclerosis during Betaferon treatment
Authors: Trushnikova T. N. , Bajdina T. V.
Published: April 2021

Depression and anxiety were examined by Hospital Anxiety and Depression Scale and Spilberger Scale in 217 multiple sclerosis patients treated by Betaferon. The concentration of blood serotonin was determined by immunoenzyme analysis in 71 of them. The multiple sclerosis patients had progressive high levels of depression ((7,55 ± 3,61) points; р = 0,000) and anxiety ((7,55 ± 3,61) points; р = 0,000), and the decreased blood serotonin concentration ((210 ± 134,2) versus (269 ± 98,8) ng/ml; р = 0,036 in healthy people). The level of anxiety was related to the level of serotonin depression. Betaferon did not correct the affective disorders in multiple sclerosis patients, except the decreasing the degree of anxiety, and did not normalize the level of blood serotonin, that suggest the use of selective serotonin reuptake inhibitors during immunomodulating therapy.
The outcomes of concomitant craniocerebral and skeletal injuries in Tashkent
Authors: Turapov A. А. , Rabinovich S. S. , Mahkamov K. E. , Burnashev M. E. , Valiyev E. Yu. , Musayev T. S.
Published: April 2021

The outcomes of concomitant craniocerebral and skeletal injuries (CCCSI) in 834 patients in the large industrial city of Tashkent during 2001—2004 are analyzed in this research. The best functional recovery rates were recorded in group IV. The complete loss of work ability number amounts 4,7% from total survived patients. The severe skeleton injuries forms the biggest II group of patients. Death from craniocerebral injuries occurred in 16,1% of patients.

Death rates increased by 9,7% times during four years of the research. Annual rate of increase of craniocerebral injuries was 4,9%. The prevalent parts of population were young (21—40 years) and middle-aged (41—60 years) persons, men — 77%. The highest death outcomes occurrence was in III group and severe skeleton injuries. Predominate cause of death — is severe skeleton injuries, lead to bleeding, DIС-syndrome, all kinds shock and severe craniocerebral injuries (SCCI) lead to brain edema and dislocation.
Clinical immunological aspects of tick-borne encephalitis
Authors: Udintseva I. N. , Chechina O. Ye. , Zhoukova N. G. , Lukashova L. V. , Ryazantseva N. V. , Poponina A. M. , Malysheva L. A. , Bartfeld N. N. , Pershina S. A.
Published: April 2021

In this article results of the clinical-immunological analysis with different forms tick-borne encephalitis of Tomsk Region during the period from 2000 to 2008 are represented. The revealled disbalance of cytokines alongside with breach of the expressions cytokines's receptor by limphocytes's cells, can be one of the main of the reasons to inefficiency answer when introducing the infectious agent in organism and shaping the chronic form to infectious pathology, in particular, with long presence of the antigen of the virus tick-borne encephalitis in blood. The trend to increase the level sick with long presence of the antigen of the virus tick-borne encephalitis in blood, with prevalence of the persons feminine flap, mainly average and senior age for the last years is given.
Impact of ecological factors in beginning of acute malfunction of cerebral blood circulation in population of industrial city in Western Siberia
Authors: Yashnikova M. V.
Published: April 2021

Examination of ecological factors in their impact of beginning of acute malfunction of cerebral blood circulation in population of one of the industrial regions of Novosibirsk. The article shows endogenous and exogenous effects of impact of appropriate factors.
Türkistan Milli Ayaklanması (1916-1917): Mali Bilanço
Authors: KARATAŞ Ömer
Published: April 2021

Rus çarlığı, Türkistan bölgesini işgal ettikten sonra bölgenin tüm yer altı ve yer üstü kaynaklarını sömürmekteydi. Çarlık, kendi lehine bölgeden sömürü yoluyla aldığı maddi kaynakların yanına insan kaynağını da ilave etmek isteyince Türkistanlılar kendine geldi. Kendine gelen Türkistanlılar bu sömürüye son vermek ve özgürlükleri için isyan başlattı. Türkistan’da çarlık rejimine karşı başlayan isyan ateşi Çar II. Nikolay’ın 25 Haziran 1916’daki fermanıyla (yabancıların askeri arka işlere alımı) başladı. 1916 Temmuzunda başlayan Türkistan Milli ayaklanması yaklaşık bir yıl sürdü. Ama isyanın bıraktığı hasar yüzlerce yıl unutulmayacaktır. Bu yıl Türkistan tarihinin en trajik ve en kanlı yılı oldu. Çünkü çarlık bölgede yüzbinlerce insanın canlarına ve mallarına kast etti. Çarlık bölgede isyana kalkışanları yaralama, idam, öldürme, hapis yoluyla canlarına, yağma, yakma, el koyma, gasp, yurtlarından çıkarma yoluyla da mallarına el koydu. İsyan sırasında Türkistanlıların bölgedeki Rus ahali tarafından keyfi olarak yağmalanmasına ve mallara el konmasına Rus kolluk kuvvetleri sesiz kalarak destek oluyorlardı. Aslında en büyük zarar da bu yaklaşım sonucu meydana geldi.
1916-1917 arasında bölgede meydana gelen isyan hareketinden dolayı hem Ruslar hem de Türkistan kadim ahalisi büyük miktarda maddi kayıp yaşadı. Fakat Türkistanlılar nerdeyse tüm gelirlerini, yaşam yerlerini, arazilerini hatta canlarını özgürlük mücadelesi yolunda feda etti. Çalışmamızı Rus belge ve raporlarına dayalı olarak ele alacağız.
Day-Ahead Hourly Operation Planning of Distribution Networks with Photovoltaic Generation Integrated by Smart Inverters via Mixed-Integer Volt/Var Optimization Problems.
Authors: ALVES DE AZEVEDO BARROS JOÃO VITOR , Flamarion Querubini Gonçalves Amilcar , Francisco do Nascimento Claudionor , Guimarães Lage Guilherme
Published: April 2021

A penetração da geração fotovoltaica distribuída nas redes de distribuição tornou-se uma realidade; entretanto, ainda impõe desafios a serem superados, como o funcionamento dessas redes com desvios mínimos nos perfis de magnitude de tensão. Assim, este trabalho propõe o planejamento diário da operação horária de redes de distribuição visando minimizar o desvio nos perfis de magnitude de tensão por meio de ajustes de tap ótimos de transformadores em subestações, ajustes ótimos de bancos de capacitores chaveados remotamente ao longo dos alimentadores primários e injeções de potência ativa e reativa da geração fotovoltaica distribuída por inversores inteligentes. Em tal problema, as variáveis de controle discretas associadas aos taps de transformadores e susceptâncias equivalentes de bancos de capacitores chaveados remotamente são tratadas por função penalidade senoidal que modificam o problema de programação não linear inteira mista original em um problema de programação não linear com apenas variáveis de decisão contínuas. Os resultados obtidos para redes de distribuição com 69 e 135 nós mostram que o modelo OVV proposto e sua metodologia de resolução são eficientes na redução do desvio nos perfis de magnitude de tensão e, ao mesmo tempo, na redução da demanda geral de potência reativa da rede de distribuição.