bluuebunny/crossref_metadata_2025 huggingface dataset:
Spillover effects of foreign direct investment on manufacturing exports and imports in Indonesia
Authors: Yasin Mohammad Zeqi , Esquivias Miguel Angel
Published: March 2023

Purpose

This study aims to identify extensive and intensive margins in exports and imports and examine whether incoming foreign direct investments (FDI) benefit local firms in Indonesia through the export and import channels.

Design/methodology/approach

Using Heckman’s two-step selection model to consider the potential of bias of self-selection in export–import participation, this study uses the firm-level data from 2008 to 2015 collected from Statistik Industri and proximate both export and import spillovers.

Findings

The authors found that internal factors are critical for a firm to be an exporter, signaling self-selection in exports and imports. Spillover effects from FDI (spatial properties) support export but lower import propensity and intensity.

Research limitations/implications

This study implies that improving human capital (absorptive capacity) is needed to accelerate export intensity and policies supporting FDI inflows in complementary sectors (noncompeting industries) can increase export propensity and intensity and reduce imports.

Originality/value

This study contributes to the literature in several ways. First, the proposed export spillovers model that accounts for impacts through a demonstration channel is applied to the import channel. Moreover, this study extends the model developed by Franco and Sasidharan (2010) and Yasin et al. (2022) by incorporating spatial spillover effects at the provincial level. Subsequently, the authors test whether a firm’s technological intensity determines export–import propensity and intensity. This can indicate whether specific sectors are more likely to participate in international activities based on their use of technology.
Outcomes and prognostic predictors of Lu‐177 PSMA radioligand therapy in metastatic castration‐resistant prostate cancer (Asian Population Study)
Authors: Chua Wei Ming , Lam Winnie Wing‐Chuen , Tong Aaron Kian‐Ti , Sultana Rehena , Kua Sandra Mei Yu , Kanesvaran Ravindran , Wong Alvin Seng Cheong , Tay Kae Jack , Cheng Tai Jit Lenith , Ng David Chee Eng , Thang Sue Ping
Published: March 2023

Aim

Lutetium‐177 (Lu‐177) prostate‐specific membrane antigen radioligand therapy (PSMA‐RLT) is a promising therapy for metastatic castration‐resistant prostate cancer (mCRPC), but there is limited data of its efficacy and safety in Asian population. We aim to explore the clinical outcomes of Lu‐177 PSMA‐RLT in this population.

Methods

We evaluated 84 patients with progressive mCRPC receiving Lu‐177 PSMA‐RLT between 9 May 2018 and 21 February 2022. Lu‐177‐PSMA‐I&T was administered at 6–8‐week intervals. Primary end point was overall survival (OS), and secondary end points included prostate‐specific antigen (PSA) progression‐free survival (PFS), PSA response rate, clinical response, toxicity assessment, and prognostic indicators.

Results

The median OS and PSA PFS were 12.2 and 5.2 months, respectively. PSA decline of ≥50% was observed in 51.8% of patients. Patients achieving PSA response had longer median OS (15.0 vs. 9.5 months, p = .03) and PSA PFS (6.5 vs. 2.9 months, p < .001). Pain score improvement was seen in 19 out of 34 patients. A hematotoxicity of ≥grade 3 was observed in 13 out of 78 patients. Multivariable analyses showed that PSA velocity, alkaline phosphatase, hemoglobin (Hb), and the number of treatment cycles were independent prognostic indicators for OS. The retrospective design was the main limitation of the study.

Conclusions

Our study demonstrated a similar safety and efficacy of Lu‐177 PSMA‐RLT in Asian mCRPC patients compared to the existing literature. A PSA decline ≥50% was associated with longer OS and PSA PFS. Several prognostic indicators for patient outcomes were also identified.
Norwegian paediatric habilitation centres judge their own competence on cerebral visual impairment as limited
Authors: Friede Pamela , Hollung Sandra Julsen , Vik Torstein , Andersen Guro Lillemoen , Cameron David Lansing , de Rodez Sigrid Aune , Haugen Olav H. , Lundervold Tonje , Nicholas Jude , Stadskleiv Kristine
Published: March 2023

Aim

Cerebral visual impairment (CVI), a frequently occurring functional impairment in children with neurodevelopmental disorders, leads to communicative, social and academic challenges. In Norway, children with neurodevelopmental disorders are assessed at paediatric habilitation centres. Our aims were to explore how CVI is identified, how paediatric habilitation centres assess their CVI competence and the reported prevalence of CVI among children with cerebral palsy.

Methods

An electronic questionnaire was sent to all 19 Norwegian paediatric habilitation centre leaders in January 2022. The results were analysed quantitatively and qualitatively. The prevalence of CVI among children with cerebral palsy was estimated using register‐based data.

Results

The questionnaire was answered by 17. Only three judged their habilitation centre as having sufficient competence on CVI. None of the centres used screening questionnaires systematically, and 11 reported that CVI assessment was not good enough. Awareness that a child may have CVI typically occurred during examinations for other diagnoses. The prevalence of CVI among children with cerebral palsy was only 8%, while CVI status was unknown in 33%.

Conclusion

Better knowledge and assessment of CVI at Norwegian paediatric habilitation centres are needed. CVI appears to be often overlooked in children with neurodevelopmental disorders.
Vertically stratified frugivore community composition and interaction frequency in a liana fruiting across forest strata
Authors: Thiel Sarina , Willems Franziska , Farwig Nina , Rehling Finn , Schabo Dana G. , Schleuning Matthias , Shahuano Tello Ney , Töpfer Till , Tschapka Marco , Heymann Eckhard W. , Heer Katrin
Published: March 2023

Vertical stratification is a key feature of tropical forests and structures plant–frugivore interactions. However, it is unclear whether vertical differences in plant‐frugivore interactions are due to differences among strata in plant community composition or inherent preferences of frugivores for specific strata. To test this, we observed fruit removal of a diverse frugivore community on the liana Marcgravia longifolia in a Peruvian rain forest. Unlike most other plants, Marcgravia longifolia produces fruits across forest strata. This enabled us to study effects of vertical stratification on fruit removal without confounding effects of plant species and stratum. We found a high number of visits of a few frugivore species in the understorey and a low number of visits of many different frugivores in the canopy and midstorey. Whereas partial and opportunistic frugivores foraged across strata with differing frequencies, obligate frugivores were only found eating fruits in the higher strata. Avian frugivores foraging in the canopy were mainly large species with pointed wings, whereas under‐ and midstorey avian foragers were smaller with rounded wings. Our findings suggest a continuous shift in the frugivore community composition along the vertical gradient, from a few generalized frugivores in the understorey to a diverse set of specialized frugivores in the canopy. This shift in the frugivore community leads to correlated, reciprocal changes from specialized to generalized plant‐frugivore interactions. Thus, we conclude that vertical niche differentiation between species in tropical forests persists even when food resources are available across strata. This highlights its role for promoting biodiversity and ecosystem functioning.

Abstract in Spanish is available with online material.
CMAS degradation of ytterbium aluminum garnets
Authors: Kitaoka Satoshi , Tanaka Makoto , Kawashima Naoki , Ito Taishi , Yokoe Daisaku , Kato Takeharu , Ogawa Takafumi , Yamazaki Naoki , Hosoya Nagisa , Nakamura Takeshi
Published: March 2023

The degradation of ytterbium aluminum garnet (YbAG) exposed to molten Ca–Mg–Fe–Al–Si–O (CMAS) at 1673 K was investigated for two kinds of dense polycrystalline YbAG with compositions deviating slightly from stoichiometry, referred to as Al‐ and Yb‐rich. The mitigation of the CMAS attack for Yb‐rich YbAG was markedly superior to that for the Al‐rich one. For both types of YbAG, corrosion progressed due to the preferential penetration of the CMAS melt along grain boundaries in the thickness direction and the simultaneous dissolution of crystal grains into the melt. The lower of the corroded region consisted of YbAG crystals with a core/shell‐I/shell‐II structure. Shell‐I contained alkaline earth, silicon, and iron cations, whereas these cations were hardly detected in shell‐II. Growth of the shell‐I region was considered to progress by dissolution and reprecipitation through the melt existing around it, and finally, the melt disappeared, resulting in the formation of a thin shell‐II region containing little of these ions. The formation and growth of the shell‐I region were found to be promoted by making the YbAG Yb‐rich, resulting in enhancement of the resistance to CMAS.
Validation of the Parental Understanding and Misperceptions about BAby's Sleep Questionnaire using auto‐videosomnography
Authors: Jang Eunyeong , Kang Solbi , Bei Bei , Chung Seockhoon , Gradisar Michael , Kahn Michal , Barnett Natalie , Suh Sooyeon
Published: March 2023

Background

Previous studies have suggested that parental cognitions about child's sleep may be an important factor underlying pediatric sleep problems. The current study aimed to (a) develop an assessment tool measuring parental understanding and misperceptions about baby's sleep (PUMBA‐Q); (b) validate the questionnaire using self‐report and objective sleep measures.

Methods

There were 1,420 English‐speaking caregivers (68.0% mothers, 46.8% of children being females, mean age 12.3 months), who has completed online self‐reported questionnaires. The PUMBA‐Q, which was developed for this study, Dysfunctional Beliefs and Attitudes about Sleep (DBAS) and Maternal Cognitions about Infant Sleep Questionnaire (MCISQ) were included to evaluate participant's thoughts on their own or child's sleep. Insomnia Severity Index (ISI) was collected to access participant's subjective insomnia severity. Brief Infant Sleep Questionnaire‐Revised (BISQ‐R) was used to assess parental‐reported child sleep. Auto‐videosomnography was used to record child's sleep.

Results

Exploratory factor analysis indicated the best fit with a 4‐factor model using 23 items (RMSEA = .039). The four subscales were labeled: (a) Misperceptions about parental intervention; (b) Misperceptions about feeding; (c) Misperceptions about child's sleep; and (d) General anxiety of parents. Internal consistency was adequate (Cronbach's alpha = .86). PUMBA‐Q scores were significantly associated with MCISQ (r = .64, p < .01), DBAS (r = .36, p < .01), ISI (r = .29, p < .01), BISQ‐R (r = .‐49, p < .01), objective child's total sleep time (r = −.24, p < .01) and objective number of parental nighttime visits (r = .26, p < .01).

Conclusions

The results demonstrated that PUMBA‐Q 23 is a valid assessment tool for parental cognitions of child sleep. The link between parental cognitions and child sleep highlights the importance of managing parental cognitions about child sleep when treating pediatric sleep problems.
Nasal capsule ossification: A histological study using human foetuses to find an association between the foetus and adult morphologies of the nasal wall
Authors: Yamamoto Masahito , Hayashi Shogo , Honkura Yohei , Hirano‐Kawamoto Ai , Katori Yukio , Murakami Gen , Rodríguez‐Vázquez José Francisco , Abe Shinichi
Published: March 2023

Recent molecular biology studies have revealed the process of nasal capsule determination. We aimed to create a fate map showing the association between the adult and embryonic components of the nasal wall and nasal capsule derivatives. We examined paraffin‐embedded histological sections between 15 mid‐term (9–16 weeks) and 12 near‐term (27–40 weeks) foetuses. Until 15 weeks, membranous ossification occurred ‘along’ the capsular cartilage, contributing to the formation of the vomer, maxilla and bony nasal septum as well as the nasal, frontal and lacrimal bones. After 15 weeks, a wide lateral part of the capsule became thin and fragmented, and degenerative cartilage was observed near the lacrimal bone, in the three conchae, and at the inferolateral end of the capsule sandwiched between the maxilla and palatine bone. The disappearing cartilages appeared to be replaced by nearby membranous bones. This type of membranous ossification did not appear to use the capsular cartilage as a ‘mould’, although the perichondrium may have a role in inducing ossification. Calcified cartilage indicated endochondral ossification in the inferior concha until 15 weeks and, later, at the bases of three conchae and around the future sphenoid sinus (i.e. the concha sphenoidalis). The capsular cartilage extended antero‐superiorly over the frontal bone and inserted into the nasal bone. At 40 weeks, the capsular cartilage remained in the cribriform plate and at the inferolateral end along the palatine bone. Consequently, less guidance from the nasal capsule seemed to provide great individual variation in the shape of the wide anterolateral wall of the nasal cavity.
A review of the use of beeswax in skincare
Authors: Nong Yvonne , Maloh Jessica , Natarelli Nicole , Gunt Hemali B. , Tristani Esther , Sivamani Raja K.
Published: March 2023

Background

Beeswax is a naturally occurring product secreted from worker bees that has varied uses in modern day. In skincare, its function ranges from its role as an occlusive, helping to create a semi‐occlusive skin barrier that minimizes transepidermal water loss; as a humectant, locking in hydration; and an emollient to soften and soothe the skin. As a natural substance, its use has been shown to help alleviate symptoms associated with common cutaneous conditions like dermatitis, psoriasis, and overgrowth of normal skin flora.

Aims

In this narrative review, we aim to describe current uses of beeswax in skincare that has been published in the literature.

Materials and methods

A review of beeswax related publications was performed by searching the PubMed database studies.

Results

A total of five clinical studies were included with three studies on animals and two studies in humans.

Discussion

Several studies show the benefits of topical beeswax in supporting the skin barrier.

Conclusion

Beeswax can be a low‐cost, natural ingredient for use in products. Further studies with topical beeswax are warranted.
Does defending affect adolescents' peer status, or vice versa? Testing the moderating effects of empathy, gender, and anti‐bullying norms
Authors: Laninga‐Wijnen Lydia , Malamut Sarah T. , Garandeau Claire F. , Salmivalli Christina
Published: March 2023

This study examined bidirectional associations between students' bully‐directed defending behavior and their peer status (being liked or popular) and tested for the moderating role of empathy, gender, and classroom anti‐bullying norms. Three waves of data were collected at 4–5‐month time intervals among 3680 Finnish adolescents (Mage = 13.94, 53.0% girls). Cross‐lagged panel analyses showed that defending positively predicted popularity and, to a larger degree, being liked over time. No moderating effect of empathy was found. Popularity was more strongly predictive of defending, and defending was more strongly predictive of status among girls than among boys. Moreover, the positive effects of both types of status on defending were—albeit to a limited extent—stronger in classrooms with higher anti‐bullying norms.
Demographic fluctuations and selection during host–parasite co‐evolution interactively increase genetic diversity
Authors: Le Pennec Guénolé , Retel Cas , Kowallik Vienna , Becks Lutz , Feulner Philine G. D.
Published: March 2023

Host–parasite interactions can cause strong demographic fluctuations accompanied by selective sweeps of resistance/infectivity alleles. Both demographic bottlenecks and frequent sweeps are expected to reduce the amount of segregating genetic variation and therefore might constrain adaptation during co‐evolution. Recent studies, however, suggest that the interaction of demographic and selective processes is a key component of co‐evolutionary dynamics and may rather positively affect levels of genetic diversity available for adaptation. Here, we provide direct experimental testing of this hypothesis by disentangling the effects of demography, selection and their interaction in an experimental host–parasite system. We grew 12 populations of a unicellular, asexually reproducing algae (Chlorella variabilis) that experienced either growth followed by constant population sizes (three populations), demographic fluctuations (three populations), selection induced by exposure to a virus (three populations), or demographic fluctuations together with virus‐induced selection (three populations). After 50 days (~50 generations), we conducted whole‐genome sequencing of each algal host population. We observed more genetic diversity in populations that jointly experienced selection and demographic fluctuations than in populations where these processes were experimentally separated. In addition, in those three populations that jointly experienced selection and demographic fluctuations, experimentally measured diversity exceeds expected values of diversity that account for the cultures' population sizes. Our results suggest that eco‐evolutionary feedbacks can positively affect genetic diversity and provide the necessary empirical measures to guide further improvements of theoretical models of adaptation during host–parasite co‐evolution.
Latent class analysis of grief‐related beliefs among recently bereaved adults
Authors: Xu Xin , Zou Xinyan , Tang Renzhihui , Jiao Keyuan , Qian Wenli , Shen Xinlan , Wang Jianping , Skritskaya Natalia A.
Published: March 2023

Grief‐related beliefs play an important role in bereavement adjustment. This study aimed to investigate the patterns and correlates of grief‐related beliefs among recently bereaved adults (n = 311). Latent class analysis results suggested three meaningful grief belief classes could be identified: the High grief belief class (24.1%), Predominantly counterfactual thoughts class (42.4%), and Low belief class (33.4%). Members in the High grief belief class reported the highest levels of grief symptoms, depression and PTSD symptoms, loneliness, and functional impairment. Compared with the Low belief class, unmarried people, people in poor health, individuals who lost parents, partners, or children, and those who experienced violent or unexpected death were more likely to belong to the High grief belief class. Findings of this study support the importance of examining grief‐related cognitions in research and clinical practice, especially counterfactual thoughts about the death, which may need to be specifically screened and targeted in treatment.
Characterization, comparison, and optimization of lattice light sheets
Authors: Liu Gaoxiang , Ruan Xiongtao , Milkie Daniel E. , Görlitz Frederik , Mueller Matthew , Hercule Wilmene , Killilea Alison , Betzig Eric , Upadhyayula Srigokul
Published: March 2023

Lattice light sheet microscopy excels at the noninvasive imaging of three-dimensional (3D) dynamic processes at high spatiotemporal resolution within cells and developing embryos. Recently, several papers have called into question the performance of lattice light sheets relative to the Gaussian sheets most common in light sheet microscopy. Here, we undertake a theoretical and experimental analysis of various forms of light sheet microscopy, which demonstrates and explains why lattice light sheets provide substantial improvements in resolution and photobleaching reduction. The analysis provides a procedure to select the correct light sheet for a desired experiment and specifies the processing that maximizes the use of all fluorescence generated within the light sheet excitation envelope for optimal resolution while minimizing image artifacts and photodamage. We also introduce a new type of “harmonic balanced” lattice light sheet that improves performance at all spatial frequencies within its 3D resolution limits and maintains this performance over lengthened propagation distances allowing for expanded fields of view.
Immune characterization of a xenogeneic human lung cross-circulation support system
Authors: Wu Wei K. , Stier Matthew T. , Stokes John W. , Ukita Rei , Patel Yatrik J. , Cortelli Michael , Landstreet Stuart R. , Talackine Jennifer R. , Cardwell Nancy L. , Simonds Elizabeth M. , Mentz Meredith , Lowe Cindy , Benson Clayne , Demarest Caitlin T. , Alexopoulos Sophoclis P. , Shaver Ciara M. , Bacchetta Matthew
Published: March 2023

Improved approaches to expanding the pool of donor lungs suitable for transplantation are critically needed for the growing population with end-stage lung disease. Cross-circulation (XC) of whole blood between swine and explanted human lungs has previously been reported to enable the extracorporeal recovery of donor lungs that declined for transplantation due to acute, reversible injuries. However, immunologic interactions of this xenogeneic platform have not been characterized, thus limiting potential translational applications. Using flow cytometry and immunohistochemistry, we demonstrate that porcine immune cell and immunoglobulin infiltration occurs in this xenogeneic XC system, in the context of calcineurin-based immunosuppression and complement depletion. Despite this, xenogeneic XC supported the viability, tissue integrity, and physiologic improvement of human donor lungs over 24 hours of xeno-support. These findings provide targets for future immunomodulatory strategies to minimize immunologic interactions on this organ support biotechnology.
Fiber pumps for wearable fluidic systems
Authors: Smith Michael , Cacucciolo Vito , Shea Herbert
Published: March 2023

Incorporating pressurized fluidic circuits into textiles can enable muscular support, thermoregulation, and haptic feedback in a convenient wearable form factor. However, conventional rigid pumps, with their associated noise and vibration, are unsuitable for most wearables. We report fluidic pumps in the form of stretchable fibers. This allows pressure sources to be integrated directly into textiles, enabling untethered wearable fluidics. Our pumps consist of continuous helical electrodes embedded within the walls of thin elastomer tubing and generate pressure silently through charge-injection electrohydrodynamics. Each meter of fiber generates 100 kilopascals of pressure, and flow rates approaching 55 milliliters per minute are possible, which is equivalent to a power density of 15 watts per kilogram. The benefits in design freedom are considerable, which we illustrate with demonstrations of wearable haptics, mechanically active fabrics, and thermoregulatory textiles.
Supplemental Material: Generating large volumes of crust-derived high δ18O rhyolites in the Chon Aike Silicic Large Igneous Province, Patagonia
Authors: Foley Michelle L. , al. et
Published: March 2023

Includes data tables of bulk-rock geochemistry, oxygen isotope values by laser fluorination and secondary ion mass spectrometry, and thermodynamic model parameters. Figures of in situ oxygen isotope analyses overlain on quartz cathodoluminescence images. Figures of additional major and trace-element bulk geochemistry plots and SIMS oxygen isotope values plotted per sample. 
Effect of Disorder on Magnetotransport in Semiconductor Artificial Graphene
Authors: Tkachenko O. A. , Tkachenko V. A. , Baksheev D. G. , Sushkov O. P.
Published: March 2023

Magnetotransport in mesoscopic samples with semiconductor artificial graphene has been simulated within the Landauer–Büttiker formalism. Model four-terminal systems in a high-mobility two-dimensional electron gas have a square shape with a side of 3–5 μm, which is filled with a short-period (120 nm) weakly disordered triangular lattice of antidots at the modulation amplitude of the electrostatic potential comparable with the Fermi energy. It has been found that the Hall resistance $${{R}_{{xy}}}(B)$$ in the magnetic field range of B = 10–50 mT has a hole plateau $${{R}_{{xy}}} = - {{R}_{0}}$$, where R0 = h/2e2 = 12.9 kΩ, at carrier densities in the lattice below the Dirac point n < n1D and an electron plateau $${{R}_{{xy}}} = {{R}_{0}}$$ at n > n1D. Enhanced disorder destroys the plateaus, but a carrier type (electrons or holes) holds. Long-range disorder at low magnetic fields suppresses quantized resistance plateaus much more efficiently than short-range disorder.
Multicomponent Current Sheet of the Magnetopause with an Arbitrary Energy Distribution of Particles
Authors: Nechaev A. A. , Kocharovsky Vl. V. , Kocharovsky V. V. , Garasev M. A.
Published: March 2023

An exact solution to the Maxwell–Vlasov equations has been found for a large class of multicomponent current sheets in collisionless plasma, which describe the spatial structure of the current in the magnetopause and consistent inhomogeneous anisotropic momentum distributions of particles with different effective temperatures. Devised sheets allow a nonmonotonic variation of the magnetic field and can have asymmetric, multihump, and sign-alternating profiles of the current density. Profiles of the current of different particle populations can have different scales, contain countercurrents, and be spatially shifted with respect to each other. The model under consideration is applicable to qualitatively describe a magnetopause separating a magnetosphere of a planet from a solar wind or separating regions of the solar wind with different parameters of the plasma and magnetic field.
Strong squeezing and robust entanglement in a second-order coupled optomechanical cavity assisted by a Kerr nonlinear medium
Authors: Mahajan Sonam , Aggarwal Neha , Bhattacherjee Aranya B.
Published: March 2023

We investigate theoretically an optomechanical system composed of an optical mode and a mechanical mode interacting through first-order coupling and second-order coupling in the presence of a Kerr nonlinear medium. We study how the nonlinearities (second-order optomechanical coupling and Kerr nonlinearity) alter the optical output spectrum, optical quadrature squeezing and optomechanical entanglement. It is shown that the intensity of the output optical spectrum decreases drastically with an increase in second-order optomechanical coupling while it increases significantly with an increase in Kerr nonlinear parameter. More interestingly, by choosing suitable second-order optomechanical coupling and detuning of the optical cavity field, one can achieve strong squeezing of the cavity light field. Further, these nonlinearities play an important role in creating robust optomechanical entanglement between optical and mechanical modes. Hence, the presence of various nonlinearities in the system can be a good platform for achieving the squeezing of light and robust optomechanical entanglement which can be used in realizing better quantum optomechanical devices.
Experimental Investigation of the Torsional Aeroelastic Instability of Single-Axis Solar Trackers
Authors: Zhang Xiaobin , Ma Wenyong , Li Haiyun , Shao Qijun , Kang Xiaohan
Published: March 2023

The torsional aerodynamic instability of single-axis solar trackers under strong wind seriously threatens the safety of solar trackers due to the occurrence of large torsional vibrations, and the corresponding mechanism is still unclear. In this study, the torque coefficient and torsional angle of a single-axis solar tracker are tested synchronously using an aeroelastic sectional model in a wind tunnel. The critical wind speed, torque coefficients, and interaction between the torsional angle and torque coefficients at different tilt angles are analyzed, and the following results can be obtained. Torsional aeroelastic instability occurs in a tilt angle range of -10° to 15°, and the critical wind speed decreases as the tilt angle increases. The standard deviation of dynamic torque coefficients is much larger than that of static torque coefficients, and torque coefficients showed a significant dominant frequency characteristic in the vibration state due to torsional vibration instead of wind load. The wind load in the windward area promotes vibration, while the wind load in the leeward area may promote vibration with the PV module tilt angle being slight and suppress vibration with the tilt angle being significant.
Development of a Novel Artificial Intelligence Model for Better Balancing Exploration and Exploitation
Authors: Son Pham Vu Hong , Trang Nguyen Thi Nha
Published: March 2023

Grey Wolf optimizer (GWO) has been used in several fields of research. The main advantages of this algorithm are its simplicity, little controlling parameter, and adaptive exploratory behavior. However, similar to other metaheuristic algorithms, the GWO algorithm has several limitations. The main drawback of the GWO algorithm is its low capability to handle a multimodal search landscape. This drawback occurs because the alpha, beta, and gamma wolves tend to converge to the same solution. This paper presents HDGM – a novel hybrid optimization model of dragonfly algorithm and grey wolf optimizer, aiming to overcome the disadvantages of GWO algorithm. Dragonfly algorithm (DA) is combined with GWO in this study because DA has superior exploration ability, which allows it to search in promising areas in the search space. To verify the solution quality and performance of the HDGM algorithm, we used twenty-three test functions to compare the proposed model’s performance with that of the GWO, DA, particle swam optimization (PSO) and ant lion optimization (ALO). The results show that the hybrid algorithm provides more competitive results than the other variants in terms of solution quality, stability, and capacity to discover the global optimum.
An International Comparison of Online Learning Transition During COVID-19
Authors: Chen Zan , Tan Bao Zhen
Published: March 2023

This article looks into the impact of COVID-19 on the digitization of work and learning, specifically for adult educators (post-secondary educators and trainers) around the world. It provides a comparison of adult educators in Singapore and their international counterparts from the United Kingdom, European Union countries, and the United States. Results show international respondents tended to view transition to online learning, teaching, and assessment (LTA) as a temporary response to the emergency due to COVID-19, while the perceptions of respondents from Singapore seemed to represent a general sentiment toward a more permanent shift to online LTA rather than an emergency response. Additionally, respondents from Singapore tended to be more positive when it came to rating the impact of the online transition. Regardless of the differences in their views, it appears online LTA is here to stay, and the immediate challenge would be to make appropriate continuing professional development arrangements to support adult educators around the world to cope with this transition. It is, therefore, hoped the lessons learned from this current study could provide useful references to a wider community in higher education and adult training to emerge strong from the pandemic.
Cardiovascular and cerebral vascular health in females with postacute sequelae of COVID-19
Authors: Nandadeva Damsara , Skow Rachel J. , Stephens Brandi Y. , Grotle Ann-Katrin , Georgoudiou Stephanie , Barshikar Surendra , Seo Yaewon , Fadel Paul J.
Published: March 2023

We demonstrate for the first time that resting blood pressure (BP) and central arterial stiffness are higher in females with PASC compared with controls. In contrast, peripheral and cerebral vascular functions appear unaffected. Moreover, there was no relationship between total PASC symptom burden and measures of BP, arterial stiffness, or vascular function. Collectively, these findings suggest that females with PASC could be at greater risk of developing hypertension, which appears independent of symptom burden.
Implementation of Modified SEPIC Converter for Renewable Energy Built DC Microgrids
Authors: Jyothi B. , Bhavana P. , Rao B. Thirumala , Pushkarna Mukesh , Kitmo  , Djidimbele Repele
Published: March 2023

The nonavailability of fossil fuels and the shortcomings of nonconventional energy sources taking place in the environment lead the research and development towards alternative and clean energy sources such as renewable energy sources. Renewable or nonconventional energy resources are being used to meet ever-increasing energy demand. The photo voltaic (PV) energy is the right choice of renewable energy for small voltage DC distribution systems, due to their advantages. But this energy source can produce low output power at the utility grid. Hence, to step up this low input voltage to high value for a range of high-voltage applications, DC-DC converters are integrated to the DC microgrids by means of PV system. The present work elaborates the modified SEPIC converter (MSC) designed based on the traditional SEPIC with a boost-up module. In comparison with conventional or traditional SEPIC converter, the proposed MSC produces high voltage gain and continuous current to the DC microgrids. Furthermore, MSC is operated with only one controlled switch. The proposed converter design improves the efficiency, output voltage, and continuous output current of the DC microgrids. This entire work is completed with PSIM, and finally, numerical simulation results prove the possibility of the MSC with PV-powered DC microgrids, and also the dynamic response of MSC for DC microgrid loads enhances the regulated output voltage and continuous output current of DC loads.
Dupilumab Therapy of Prurigo Nodularis: A Single‐Center, Real‐Life Observational Study
Authors: Jing Wenwen , Yang Danyang , Liu Xin , Li Li , Lu Tao , Li Xiaoli
Published: March 2023

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by severe itching accompanied by multiple nodules throughout the body. There is currently no effective drug‐targeted treatment for PN. Dupilumab is a fully human monoclonal antibody which can suppress the Th2 inflammatory reaction. We aimed to assess the efficacy and safety of dupilumab in PN. There were 29 PN patients who received dupilumab treatment for four months. Serum total immunoglobulin E (Ig E), eosinophil counts, dermatology life quality index (DLQI), and numeric rating scale (NRS) were assessed on patients before and after treatment. We count the vaccination of novel coronavirus pneumonia (COVID‐19) in patients and the impact on PN and treatment measures after vaccination. Plotting was performed using GraphPad Prism8, and the statistical analysis was performed using PASW Statistics18. The eosinophil counts in patients higher decreased to normal, and the Ig E levels gradually decreased and tended to normal levels after receiving dupilumab injection. The average DLQI score at the baseline was 23.93 ± 0.66 and decreased to 11.66 ± 0.55 (P < 0.01) and 1.83 ± 0.22 (P < 0.01) at 1‐month and 6‐monthfollow‐up of treatment, respectively. The average NRS score at the baseline was 9.79 ± 0.08 and decreased to 3.52 ± 0.23 (P  <  0.01) and 0.31 ± 0.15 (P  <  0.01) at the 1‐month and 6‐monthfollow‐up of treatment, respectively. Our study shows that dupilumab has achieved good efficacy in PN with few adverse reactions and high safety. We can recommend that patients follow the advice of specialists to be vaccinated and under the condition of stable disease, separated from dupilumab treatment for one week.
Improvement in Racial Disparities in Heart Transplantation following the Heart Allocation Policy Change
Authors: Sherard Curry , Skidmore Savannah , Shorbaji Khaled , Welch Brett A. , Bhandari Krishna , Kilic Arman
Published: March 2023

Objectives. Heart transplantation (HT) is a definitive therapy for refractory heart failure, making it the gold-standard treatment for recipients with end-stage disease. Heart allocation policy (HAP) in the United States was changed on October 18th, 2018. The aim of this study was to assess the effect of the new policy on racial disparities in heart transplantation (HT) outcomes. Methods. The United Network for Organ Sharing (UNOS) registry was used to identify adult recipients undergoing isolated HT between 2010 and 2021. Recipients were stratified into pre-HAP (January 2010 to September 2018) vs. post-HAP (October 2018 to September 2021). Recipient race was classified as White, Black, Hispanic, or other. The primary outcome was post-HT mortality. Cox proportional hazard models were used for risk-adjustment in evaluating the independent effect of race on post-HT mortality. Results. A total of 27,403 recipients underwent HT in 143 centers during study period. The proportion of non-Whites undergoing HT increased in the post-HAP era: (pre-HAP: White 66.0%, Black 21.2%, Hispanic 8.2%, Other 4.6% versus post-HAP: White 62.5%, Black 23.2%, Hispanic 9.5%, Other 4.8%;

p
<
0.001

). In risk-adjusted analysis, Black recipients were at higher risk of post-HT mortality in the pre-HAP era (HR 1.31, 95% CI 1.22–1.41;

p
<
0.001

) but not in the post-HAP era (HR 1.12, 95% CI 0.03–1.34;

p
=
0.222

) compared to White recipients. Other non-White recipients had comparable risk-adjusted post-HT mortality rates compared to White recipients both in the pre-HAP and post-HAP eras. Conclusions. Under the new heart allocation system, a higher percentage of recipients are non-White. In addition, racial disparities in HT outcomes have improved with Black recipients no longer having an increased risk-adjusted mortality following HT.
Supplementary Table 1 from IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2
Authors: Mongroo Perry S. , Noubissi Felicite K. , Cuatrecasas Miriam , Kalabis Jiri , King Catrina E. , Johnstone Cameron N. , Bowser Mark J. , Castells Antoni , Spiegelman Vladimir S. , Rustgi Anil K.
Published: March 2023

Supplementary Table 1 from IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2
Supplementary Figure 2 from Inhibition of Neurotensin Receptor 1 Selectively Sensitizes Prostate Cancer to Ionizing Radiation
Authors: Valerie Nicholas C.K. , Casarez Eli V. , DaSilva John O. , Dunlap-Brown Marya E. , Parsons Sarah J. , Amorino George P. , Dziegielewski Jaroslaw
Published: March 2023

PDF file - 116K
Supplementary Video 1 from Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: In Silico Modeling Integrates Imaging and Histology
Authors: Swanson Kristin R. , Rockne Russell C. , Claridge Jonathan , Chaplain Mark A. , Alvord Ellsworth C. , Anderson Alexander R.A.
Published: March 2023

WMV file - 1.1MB
Supplementary Figure 4 from Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis
Authors: Voisin Thierry , El Firar Aadil , Fasseu Magali , Rouyer-Fessard Christiane , Descatoire Véronique , Walker Francine , Paradis Valérie , Bedossa Pierre , Henin Dominique , Lehy Thérèse , Laburthe Marc
Published: March 2023

Supplementary Figure 4 from Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis
Supplementary Methods from Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors
Authors: Ditte Peter , Dequiedt Franck , Svastova Eliska , Hulikova Alzbeta , Ohradanova-Repic Anna , Zatovicova Miriam , Csaderova Lucia , Kopacek Juraj , Supuran Claudiu T. , Pastorekova Silvia , Pastorek Jaromir
Published: March 2023

PDF file - 78K
Supplementary Tables 1-2 from Oncogene-Mediated Human Lung Epithelial Cell Transformation Produces Adenocarcinoma Phenotypes In Vivo
Authors: Sasai Ken , Sukezane Taiko , Yanagita Emmy , Nakagawa Harumi , Hotta Azusa , Itoh Tomoo , Akagi Tsuyoshi
Published: March 2023

Supplementary Tables 1-2 from Oncogene-Mediated Human Lung Epithelial Cell Transformation Produces Adenocarcinoma Phenotypes In Vivo
Supplementary Figure 2 from STAT3 Inhibition Is a Therapeutic Strategy for ABC-like Diffuse Large B-Cell Lymphoma
Authors: Scuto Anna , Kujawski Maciej , Kowolik Claudia , Krymskaya Ludmila , Wang Lin , Weiss Lawrence M. , DiGiusto David , Yu Hua , Forman Stephen , Jove Richard
Published: March 2023

Supplementary Figure 2 from STAT3 Inhibition Is a Therapeutic Strategy for ABC-like Diffuse Large B-Cell Lymphoma
Supplementary Figure 4 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage
Authors: Fitzgerald Daniel P. , Subramanian Preeti , Deshpande Monika , Graves Christian , Gordon Ira , Qian Yongzhen , Snitkovsky Yeva , Liewehr David J. , Steinberg Seth M. , Paltán-Ortiz José D. , Herman Mary M. , Camphausen Kevin , Palmieri Diane , Becerra S. Patricia , Steeg Patricia S.
Published: March 2023

PDF file - 4.9MB
Supplementary Figure 3 from Real-time Raman Spectroscopy for In Vivo Skin Cancer Diagnosis
Authors: Lui Harvey , Zhao Jianhua , McLean David , Zeng Haishan
Published: March 2023

PDF file - 38K, ROC curve for discriminating melanoma (n = 44) from biopsied benign pigmented skin lesions (n =81).
Supplementary Table 1 from The Human TLR Innate Immune Gene Family Is Differentially Influenced by DNA Stress and p53 Status in Cancer Cells
Authors: Shatz Maria , Menendez Daniel , Resnick Michael A.
Published: March 2023

PDF file - 105K, The best predicted p53RE-related sequence in the promoter regions (� 5 kb from transcription start site) of human TLR genes
Supplementary File 1 from The Human TLR Innate Immune Gene Family Is Differentially Influenced by DNA Stress and p53 Status in Cancer Cells
Authors: Shatz Maria , Menendez Daniel , Resnick Michael A.
Published: March 2023

PDF file - 96K, The p53 occupancy at the TLR promoters as assessed by ChIP analysis and quantified by SYBR Green qPCR
Supplementary Methods, Tables 1-9, Figures 1-5 from Nanocarriers Enhance Doxorubicin Uptake in Drug-Resistant Ovarian Cancer Cells
Authors: Arora Hans C. , Jensen Mark P. , Yuan Ye , Wu Aiguo , Vogt Stefan , Paunesku Tatjana , Woloschak Gayle E.
Published: March 2023

PDF file - 1.35MB
Supplementary Table 3 from A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer
Authors: Li Ning , Kaur Sippy , Greshock Joel , Lassus Heini , Zhong Xiaomin , Wang Yanling , Leminen Arto , Shao Zhongjun , Hu Xiaowen , Liang Shun , Katsaros Dionyssios , Huang Qihong , Bützow Ralf , Weber Barbara L. , Coukos George , Zhang Lin
Published: March 2023

PDF file - 124K
Supplementary Table 1 from Hematologic β-Tubulin VI Isoform Exhibits Genetic Variability That Influences Paclitaxel Toxicity
Authors: Leandro-García Luis J. , Leskelä Susanna , Inglada-Pérez Lucía , Landa Iñigo , de Cubas Aguirre A. , Maliszewska Agnieszka , Comino-Méndez Iñaki , Letón Rocío , Gómez-Graña Álvaro , Torres Raúl , Ramírez Juan Carlos , Álvarez Sara , Rivera José , Martínez Constantino , Lozano María Luisa , Cascón Alberto , Robledo Mercedes , Rodríguez-Antona Cristina
Published: March 2023

PDF file - 72KB, Characteristics of the human cells used for qRT-PCR
Supplementary Figure 2 from A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer
Authors: Li Ning , Kaur Sippy , Greshock Joel , Lassus Heini , Zhong Xiaomin , Wang Yanling , Leminen Arto , Shao Zhongjun , Hu Xiaowen , Liang Shun , Katsaros Dionyssios , Huang Qihong , Bützow Ralf , Weber Barbara L. , Coukos George , Zhang Lin
Published: March 2023

PDF file - 964K
Supplementary Figure 1 from A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer
Authors: Li Ning , Kaur Sippy , Greshock Joel , Lassus Heini , Zhong Xiaomin , Wang Yanling , Leminen Arto , Shao Zhongjun , Hu Xiaowen , Liang Shun , Katsaros Dionyssios , Huang Qihong , Bützow Ralf , Weber Barbara L. , Coukos George , Zhang Lin
Published: March 2023

PDF file - 540K
Supplementary Figure Legends 1-7, Methods from Transcription Factor NFATc2 Controls the Emergence of Colon Cancer Associated with IL-6–Dependent Colitis
Authors: Gerlach Katharina , Daniel Carolin , Lehr Hans A. , Nikolaev Alexei , Gerlach Thomas , Atreya Raja , Rose-John Stefan , Neurath Markus F. , Weigmann Benno
Published: March 2023

PDF file - 106K
Supplementary Methods from Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)
Authors: Holt Sarah V. , Logie Armelle , Davies Barry R. , Alferez Denis , Runswick Sarah , Fenton Sarah , Chresta Christine M. , Gu Yi , Zhang Jingchuan , Wu Yi-Long , Wilkinson Robert W. , Guichard Sylvie M. , Smith Paul D.
Published: March 2023

PDF file - 78K
Supplementary Figure 4 from Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response
Authors: Chang Hsin-Yi , Huang Hsuan-Cheng , Huang Tsui-Chin , Yang Pan-Chyr , Wang Yi-Ching , Juan Hsueh-Fen
Published: March 2023

PDF file, 215K, Citreoviridin does not induce apoptosis in CL1-0 or A549 cells.
Supplementary Video 2 from Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis
Authors: Endo Motoyoshi , Nakano Masahiro , Kadomatsu Tsuyoshi , Fukuhara Shigetomo , Kuroda Hiroaki , Mikami Shuji , Hato Tai , Aoi Jun , Horiguchi Haruki , Miyata Keishi , Odagiri Haruki , Masuda Tetsuro , Harada Masahiko , Horio Hirotoshi , Hishima Tsunekazu , Nomori Hiroaki , Ito Takaaki , Yamamoto Yutaka , Minami Takashi , Okada Seiji , Takahashi Takashi , Mochizuki Naoki , Iwase Hirotaka , Oike Yuichi
Published: March 2023

AVI file - 6.8MB
Supplementary Figure 8 from Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma
Authors: Corre Jill , Labat Elodie , Espagnolle Nicolas , Hébraud Benjamin , Avet-Loiseau Hervé , Roussel Murielle , Huynh Anne , Gadelorge Mélanie , Cordelier Pierre , Klein Bernard , Moreau Philippe , Facon Thierry , Fournié Jean-Jacques , Attal Michel , Bourin Philippe
Published: March 2023

PDF file - 67K, Transfection of BM-MSC with plasmids encoding shRNA targeting GDF15 and co-culture with MOLP-6 cells
Supplementary Figure 5 from Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma
Authors: Corre Jill , Labat Elodie , Espagnolle Nicolas , Hébraud Benjamin , Avet-Loiseau Hervé , Roussel Murielle , Huynh Anne , Gadelorge Mélanie , Cordelier Pierre , Klein Bernard , Moreau Philippe , Facon Thierry , Fournié Jean-Jacques , Attal Michel , Bourin Philippe
Published: March 2023

PDF file - 44K, Concentration of GDF15 measured by ELISA in 72 hours culture supernatants of primary BM-MSCs and MM cells from 3 patients, and MM cell lines MOLP-6 and MM1.S
Supplementary Figure 4 from Raf Kinase Inhibitor RKIP Inhibits MDA-9/Syntenin-Mediated Metastasis in Melanoma
Authors: Das Swadesh K. , Bhutia Sujit K. , Sokhi Upneet K. , Azab Belal , Su Zhao-zhong , Boukerche Habib , Anwar Talha , Moen Erika L. , Chatterjee Devasis , Pellecchia Maurizio , Sarkar Devanand , Fisher Paul B.
Published: March 2023

PDF file - 604K, MDA-9 activates ERK1/2
Supplementary Methods from Monoallelic Expression Determines Oncogenic Progression and Outcome in Benign and Malignant Brain Tumors
Authors: Walker Erin J. , Zhang Cindy , Castelo-Branco Pedro , Hawkins Cynthia , Wilson Wes , Zhukova Nataliya , Alon Noa , Novokmet Ana , Baskin Berivan , Ray Peter , Knobbe Christiane , Dirks Peter , Taylor Michael D. , Croul Sidney , Malkin David , Tabori Uri
Published: March 2023

PDF file - 75K