bluuebunny/crossref_metadata_2025 huggingface dataset:
An Exploration of Cohesion and Coherence Skills in Neuropsychiatric Disorder: Speech Language Pathologist Perspective
Authors:   Research Officer, Department of Speech-Language Sciences, All India Institute of Speech and Hearing, Manasagangothri, Mysuru, India, M Pallickal , P Deepak ,   Assistant Professor, Father Muller College of Speech and Hearing, Mangalore, India, BP Abhishek ,   Associate Professor and Research Coordinator, Nitte Institute of Speech and Hearing, KS Hegde Medical College Complex, Deralakatte, Mangalore, India, N Hema ,   Assistant Professor in Speech Sciences, Department of Speech-Language Sciences, All India Institute of Speech and Hearing, Manasagangothri, Mysuru, India
Published: April 2024

Discourse task is assumed to unveil the dyssynchrony between thought and language in an Individual with Schizophrenia (IWS). We investigated the narrative discourse abilities of a schizophrenia participant using qualitative and quantitative methods of discourse analysis. Discourse samples of picture description and narration were video recorded and transcribed using International Phonetic Alphabet (IPA). The transcribed samples were subjected to two methods of analysis such as qualitative and quantitative discourse analysis to see the pattern of discourse production. The qualitative analysis of discourse was carried out using a standardized “Discourse Analysis Scale” (DAS) and the quantitative analysis was done using Thematic-Unit Analysis (T-unit analysis) for narration and picture description task. The qualitative analysis of discourse revealed deficits at the level of propositional and non-propositional aspects of communication for narration and picture description task. Quantitative analysis revealed a higher proportion of T-units for picture description task. In conclusion, it is important to establish both qualitative and quantitative analysis of discourse to document the presence of deficits at propositional and non-propositional aspects of communication. Using both the method of analysis would help the clinician to profile the cognitive-linguistic impairment in an IWS, which will further facilitate the clinician to device and deliver better treatment for IWS.
Schizophrenia and Sexual Behaviour
Authors:   Department of Psychology, Mithibai College of Arts, India, R Sanghvi
Published: April 2024

Schizophrenia is a chronic and severe mental health condition characterized by a range of symptoms, including hallucinations, delusions, disorganized thinking, and speech difficulties. Sexual behaviour in individuals with schizophrenia can be affected by a combination of factors, including the symptoms of the condition, medication side effects, social factors, and personal beliefs and values. Research suggests that individuals with schizophrenia are more likely to have issues with intimacy, experience difficulties with sexual functioning, and engage in risky sexual behaviour. Treatment strategies for these issues may include addressing the underlying causes of sexual dysfunction, developing appropriate communication skills, and providing support to promote healthy sexual relationships. Overall, understanding the complex relationship between schizophrenia and sexual behaviour is important for promoting the overall wellbeing of individuals living with this condition.
Case Report of Cellgram® Autologous Mesenchymal Stem Cell Treatment for Relapsing-Remitting Multiple Sclerosis
Authors:   Department of Rehabilitation Medicine, Ilsan-ro 20, Wonju-si, Kangwon-do, 26426, Republic of Korea, Choi Won Woo , Yong Sang Yeol ,   Department of Rehabilitation Medicine, Ilsan-ro 20, Wonju-si, Kangwon-do, 26426, Republic of Korea, Kim Hyun Soo ,   R&D Center, Pharmicell Co. Ltd., Seongnam 13229, Korea, Lee Jeonghwan ,   Pharmicell, Pharmicell Co. Ltd., Seongnam 13229, Korea, Hwang Ju Eun ,   Pharmicell, Pharmicell Co. Ltd., Seongnam 13229, Korea, Jeong Chang Ho ,   Dr. Kim’s Stem Cell Clinic, 874 Eonju-ro Gangnam, Seoul,06027, Republic of Korea, Lee Gawhan ,   Dr. Kim’s Stem Cell Clinic, 874 Eonju-ro Gangnam, Seoul,06027, Republic of Korea
Published: April 2024

Multiple sclerosis is an autoimmune disease of the central nervous system that is increasing worldwide but difficult to diagnose and treat. Previous studies have revealed that the autologous Mesenchymal Stem Cells (MSC) for MS may serve as a possible effective tool for cell-based therapy of inflammatory, immune-mediated, and degenerative diseases due to their immunomodulatory, immunosuppressive, and regenerative potentials. This case report presents a patient diagnosed with Relapsing-Remitting Multiple Sclerosis (RRMS) who was treated with an autologous mesenchymal stem cell drug (Cellgram®). We administered two doses of Cellgram® to a 54-year-old Southwest Asian male with a 28-year history of RRMS. Changes were also observed in manual muscle strength test, range of motion, and lower extremity stiffness, but the biggest change was in functional performance. Before treatment, the patient was unable to stand without assistance even with an orthosis, but was able to stand up from a wheelchair using a walker on the 24th day after the first injection, and was able to stand up from the wheelchair without assistance on the 26th day. Thirty days after the first injection, and 3 days after the second injection, he was able to walk a few steps back and forth using a walker. Five months after the first injection, he was able to climb six steps. In conclusion, this case report illustrates that MSC therapy might serve as a potential therapeutic option for RRMS as it may be a safe and effective treatment for MS patients.
Clinical Activity of Sirolimus in Classic Kaposi’s Sarcoma Patients: Long-Term Remission of Lesions
Authors:   Department of Medical Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China, SU Zhimin , Li Fang ,   Department of Medical Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China, Gan Hexia X ,   Department of Medical Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China, Zheng Jingmei ,   Department of Pathology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China, Wang Zhiming ,   Department of Medical Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China, Zhou Yuhong ,   Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
Published: April 2024

Introduction: Kaposi’s sarcoma (KS) is a multicentric angiomatous neoplasm of lymphatic endothelium-derived cells that leads to angioproliferative diseases and affects the skin and internal organs. Currently, the main treatment options include radiotherapy, chemotherapy and targeted treatment. However, due to the low incidence rate and high malignancy, prognosis remains dismal and thus novel strategies are warranted. Methods: We treated 3 cases of KS with sirolimus, and evaluated the effectiveness and related side effects. Two were not suitable for chemotherapy, andone refused chemotherapy. Results: In this study, three patients all achieved symptom relief within three days. One patient died of pulmonary infection, and the overall survival time was 12.0 months. The other two patients had not reached disease progression, and the progression free survival time (PFS) of one patient was more than 18 months. The main adverse reaction was grade 1-2 oral mucositis, which was well controlled and well tolerated. Conclusion: This study shows the long-term remission of lesions and satisfactory safety of oral sirolimus in KS patients who are unsuitable for chemotherapy or refuse chemotherapy.
Impact of Nodal Metastasis on Survival in Clear Cell Sarcoma
Authors:   Department of Orthopedic Surgery, Osaka International Cancer Institute, Japan, Tamiya Hironari , Imura Yoshinori ,   Department of Orthopedic Surgery, Osaka International Cancer Institute, Japan, Wakamatsu Toru ,   Department of Orthopedic Surgery, Osaka International Cancer Institute, Japan, Outani Hidetatsu ,   Department of Orthopedic Surgery, Osaka University Hospital, Japan, Kakunaga Shigeki ,   Department of Orthopedic Surgery, Osaka International Cancer Institute, Japan, Takenaka Satoshi ,   Department of Orthopedic Surgery, Osaka International Cancer Institute, Japan
Published: April 2024

Aim: Clear Cell Sarcoma (CCS) of soft tissue is a high-grade malignancy that often occurs on the distal extremities. The five-year overall survival is reported to be around 40%. Lymph node metastasis, that is categorized into stage IV in the latest American Joint Committee on Cancer (AJCC, 8th edition) staging system, is characteristic in CCS. We here focused on the impact of nodal metastasis on prognosis in CCS. Methods: We performed a retrospective analysis of 37 patients with CCS who were treated between 1982 and 2023. This study investigated age, gender, tumor size, tumor location, AJCC stage (7th and 8th edition), presence of lymph node or distant metastasis, presence of surgery, chemotherapy, radiotherapy, and surgical margin. Statistical analysis was conducted to evaluate the impact of each factor on survival. Results: In our cohort, tumor location, tumor size, and stage were significant prognostic factors. Notably, the disease-Specific Survival (DSS) in patients with nodal and/or distant metastasis was significantly shorter than those with no metastasis while DSS in the patients with nodal metastasis was not significantly different from those with distant metastasis. Conclusion: Consistent with the latest AJCC 8th edition in which nodal and distant metastasis are both categorized into stage IV, there was no difference in DDS between nodal metastasis and distant metastasis in CCS in the present study. This result highlights the importance of nodal metastasis in CCS.
Acute Promyelocytic Leukaemia in Adults at Chris Hani Baragwanath Academic Hospital
Authors:   McMillan B. Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa, B McMillan , M Patel ,   McMillan B. Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa, F Rahman ,   McMillan B. Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa, V Philip ,   McMillan B. Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa, A Lakha ,   McMillan B. Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa, MF Waja ,   McMillan B. Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
Published: April 2024

Background: Acute Promyelocytic Leukaemia (APL) is a subtype of Acute Myeloid Leukaemia (AML). APL is a medical emergency due to its high early mortality rate, most commonly due to bleeding complications resulting from an associated coagulopathy. However, APL is eminently treatable. Aim: The aim of the study was to review the clinical profile as well as the outcome of adult patients presenting with APL, to a tertiary, public sector hospital (Chris Hani Baragwanath Academic Hospital -CHBAH) in Soweto, Johannesburg, South Africa. Patients and Methods: This study entailed a retrospective review of 79 evaluable patients with APL, seen over a 25 year period. Results: Of the 79 evaluable patients, there were 39 males (49.37%) and 40 females (50.63%), with a female to male ratio of 1.03:1. The median age at presentation was 32 years. APL coagulopathy was evident at presentation, with 82.05% of the patients presenting with bleeding and 4.29% presenting with thrombosis. Laboratory evaluation revealed that 93.42% of the patients had anaemia and 97.37% of the patients had thrombocytopenia, while 63.93% of the patients had evidence of a DIC (disseminated intravascular coagulopathy). The Sanz risk score indicated high-risk APL in 26.32% of the patients. HIV seropositivity was present in 17.72% of the patients. After excluding patients with “early mortality’, the median survival was 43.7 months. Conclusion: APL most commonly presents with bleeding manifestations, anaemia, thrombocytopenia and DIC, which contribute to a high “early mortality’ rate. APL is eminently treatable with appropriate supportive care and specific therapy (including ATRA – all trans retinoic acid, arsenic trioxide and chemotherapy). Therefore, early diagnosis and timeous referral of APL patients is of paramount importance in order to decrease the high early mortality and improve the overall outcome of patients harbouring the disease.
Fibrinogen Based Resuscitation in Trauma Induced Coagulopathy Decreases Blood-Derived Products Consumption: A Retrospective Study
Authors:   Intensive Care Unit, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal, GN de Jesus , S Cunha ,   University Intensive Care Medicine Clinic, Faculty of Medicine of Lisbon, Lisbon, Portugal, L Carneiro ,   Clinical Pathology Service, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal, J Galacho ,   Anesthesiology Department, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal, SM Fernandes ,   University Intensive Care Medicine Clinic, Faculty of Medicine of Lisbon, Lisbon, Portugal
Published: April 2024

Introduction: Trauma-Induced Coagulopathy (TIC) is associated with increased early transfusion requirements, organ failure and high mortality. Fibrinogen or Fresh Frozen Plasma (FFP) based strategies are both used for its treatment. This retrospective study compares initial resuscitation strategies and its implication in consumption of (BDP) in trauma patients. Methods: Observational cohort retrospective study of patients with major trauma, admitted in a tertiary Intensive Care Unit (ICU) between 2013 and 2017 that received any BDP in the first 24 hour after admission. Primary outcome was the difference of RBC and total BDP administration at 24h between groups. Secondary outcomes were the impact of each strategy on ICU mortality, ICU length of stay and acute kidney injury. Non-parametric statistical tests were applied. Results: We included 104 trauma patients, 89% submitted to bleeding control surgery, with a median age of 46 (IQ: 31-62) and SAPSII of 39 (IQ: 26-51). Over the years of the study there was an increase in the use of fibrinogen use. Patients were subdivided into FFP (n=34) or fibrinogen group (n=70) according to the predominant use of each. The consumption of total BDP at 24h and RBC at 6h were lower in the fibrinogen group (p<0.01, p=0.05, respectively). There was a statistically difference in urea values at 24h (p=0.002), which may indicate less organ dysfunction in fibrinogen group. There was no difference in ICU mortality, although we observed an increased in ICU length in the FFP group (p=0.01). Conclusion: Compared with FFP-based treatment, the initial management with fibrinogen concentrate may decrease the consumption of total BDP at 24h after ICU admission.
Severe Gross Hematuria Associated with Antithrombotic Drugs: Management and Impact on Prescription Thereafter
Authors:   Univ Rennes, CHU Rennes, EA 7449 [Pharmacoepidemiology and Health Services Research] REPERES, F 35043 Rennes, France, J Bouget , F Balusson ,   Univ Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France, PM Roy ,   Emergency Department, Angers University Hospital, Institut MITOVASC, Université d’Angers, F 49033 Angers, France, D Viglino ,   Emergency Department, Grenoble-Alpes University Hospital, F 38043 Grenoble, France, L Pavageau ,   Emergency Department, University hospital, F 44093 Nantes, France, K Lacut ,   CIC 1412, Université de Bretagne Loire, Université de Brest, INSERM CIC 1412, CHRU de Brest, F 29200 Brest, France; †who passed away in April 2021, ZE Khene ,   Department of Urology, Rennes University Hospital, F 35033 Rennes, France, LM Scailteux ,   Univ Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France, E Oger ,   Univ Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France
Published: April 2024

Anfibatide is a synthetic antiplatelet thrombolysin derived from snake venom and is proposed to treat ischemic stroke and cerebral ischemia-reperfusion injury. Current standard treatments for ischemic stroke include the administration of rt-PA, a thrombolytic agent, or endovascular removal of thrombi. However, the post-treatments are often associated with the occlusion of vessels due to a lack of antiplatelet and unrecovered vessel injury. Anfibatide, as a GPIba antagonist that interrupts the initiation of platelet aggregation caused by GPIba-vWF binding, becomes a potential novel candidate for treating ischemic stroke due to its antiplatelet and antithrombosis effects. Key findings show that Anfibatide can significantly reduce microthrombus formation in cerebral vessels and reduce neuron apoptosis due to the release of pro-inflammatory mediators caused by ischemia or Ischemia-Reperfusion (I/R) injury. Significant improvement in neurological scores and reversal of brain structure alterations are observed in the Anfibatide-treated ischemic animal models. To facilitate the clinical development of Anfibatide, this paper aims to summarize the completed preclinical studies and the Phase I clinical trial results of anfibatide to evaluate the risks and therapeutic potentials of Anfibatide in ischemic patients.
Capturing Carbon Dioxide from Air with Charged-Sorbents
Authors: Li Huaiguang , Zick Mary E. , Trisukhon Teedhat , Signorile Matteo , Liu Xinyu , Eastmond Helen , Sharma Shivani , Spreng Tristan , Taylor Jack , Gittins Jamie W. , Farrow Cavan , Lim S. Alexandra , Crocellà Valentina , Milner Phillip J. , Forse Alexander C.
Published: April 2024

Emissions reduction and greenhouse gas removal from the atmosphere are both necessary to achieve net-zero emissions and limit climate change.1 There is thus a need for improved sorbents for the capture of carbon dioxide from the atmosphere, a process known as direct air capture. In particular, low-cost materials that can be regenerated at low temperatures would overcome the limitations of current technologies. In this work, we introduce a new class of designer sorbent materials known as “charged-sorbents”. These materials are prepared through a battery-like charging process which accumulates ions in the pores of low-cost activated carbons, with the inserted ions then serving as adsorption sites for carbon dioxide adsorption. We use our charging process to accumulate reactive hydroxide ions in the pores of a carbon electrode, and find that the resulting sorbent material can rapidly capture carbon dioxide from ambient air via (bi)carbonate formation. Unlike traditional bulk carbonates, charged-sorbent regeneration can be achieved at low temperatures (90-100 ºC), and the sorbent's conductive nature permits direct Joule heating regeneration2,3 using renewable electricity. Given their highly tailorable pore environments and low cost, we anticipate that charged-sorbents will find numerous potential applications in chemical separations, catalysis, and beyond.
Design of Non-Depleting Electrolyte Additive to Prolong the Cycle Life of Practical Lithium-Sulfur Batteries
Authors: Wang Xiaowei , Parab Saurabh , Bhamwala Bhargav , Raghavendran Ganesh , Han Bing , Bai Shuang , Liu Alex , Li Weikang , Miyagishima Matthew , Wang Shen , Meng Ying Shirley
Published: April 2024

Battery technology is pivotal in addressing energy efficiency and environmental sustainability challenges. Lithium-sulfur (Li-S) batteries feature promising high energy density and sustainability, but are hindered by a short cycle life under lean lithium and electrolyte conditions. A critical hurdle for Li-S batteries is the selection of an optimal electrolyte solution, crucial for controlling effective polysulfide electrochemical reactions. The conventional ether- based Li-S electrolyte, consisting of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and lithium nitrate (LiNO3), frequently suffers from LiNO3 depletion in high-energy-density applications. To address the capacity decay in Li-S batteries caused by LiNO3 depletion, this investigation introduces 2-nitrophenol lithium (NPL) as an alternative. By incorporating 25 1 mM NPL and 1 M LiTFSI in a 1,3-dioxolane/1,2-dimethoxyethane (DOL/DME) solvent, NPL mediates polysulfide oxidation during charging and prevents polysulfide corrosion, therefore improving Li retention and plating behavior. This results in Li-S batteries with NPL achieving 310 cycles, significantly surpassing the 75 cycles observed with traditional LiNO3-containing electrolytes using lean lithium anode. Pouch cells incorporating NPL exhibit stable cycling over 80 cycles, maintaining 75% of their capacity. The molecular structure of NPL prevents decomposition and facilitates interaction with polysulfides to minimize corrosion, positioning it as a strong substitute for LiNO3. This highlights NPL as a promising solution for extending the lifespan of Li-S batteries.
Enzyme-Mediated Cross-Benzoin Reaction of Highly Enolizable Aldehydes and Aryl Aldehydes for Acess to Chiral Phosphonates
Authors: Li Huangong , Yu Ling , Zhu Zheng , Wu Dongqi , Ju Yongyuan , Li Dan , Zhang Jingyu , Zhu Guoliang , Zhang Lixin , Chi Yonggui Robin , Xie Yongtao
Published: April 2024

Enzymatic catalysis has emerged as an attractive technology for organic synthesis but remains in its infancy for constructing biologically-relevant chiral phosphonates. Here, we disclose a highly chemo- and enantioselective reactions between highly enolizable 2-phosphonate aldehydes and aryl aldehydes for synthesis of chiral phosphonates. This reaction mediated by PfBAL or its mutant A28G features the first example of cross-benzoin reaction involving highly enolizable aldehydes, an elusive challenge previously. Unlike the small molecule NHC-mediated process that give complex mixture of multiple adducts, our enzymatic process selectively gives biologically active hydroxyl ketone-containing phosphonate products in excellent yields and enantioselectivities. The chiral phosphonate products can be obtained on gram scales and carry rich reactivities for further downstream transformation to afford diverse molecules, which will bring more opportunity to the development of novel C-P drugs. This work opened a new avenue in the development of novel cross-benzoin reaction and will stimulate the widespread application of cross-benzoin in organic synthesis.
LEGO Biochemistry: Fatty Acid Beta-Oxidation Made Visual
Authors: Choo Yvonne Shuen Lann
Published: April 2024

Fatty Acid Beta-Oxidation (FABO) is often taught as part of the lipid metabolism chapter in many undergraduate biochemistry syllabi. As a spiral metabolic pathway, its number of cycles depend on the length and types of fatty acid being metabolized. For simplification purposes, textbooks usually omit certain steps involved in the metabolism of fatty acid, showing only about 6 steps for a 32 steps reaction. This greatly reduces students’ cognitive clarity towards the process and its subsequent ATP calculations. To overcome such issues, an approach to teach FABO using LEGO bricks as hands-on visualization tools has been developed and implemented. Students could now follow the full progression of FABO by interacting with the palm-sized bricks, regardless of the length and types of fatty acid being studied. The approach is able to help students learn FABO and its corresponding ATP calculations with ease and further encourages the use of LEGO bricks in the visualization of other metabolic pathways in biochemistry.
Modern Electrospray Ionization Mass Spectrometry Techniques for the Characterisation of Supramolecules and Coordination Compounds
Authors: Geue Niklas
Published: April 2024

Mass spectrometry is routinely used for myriad applications in clinical, industrial, and research laboratories worldwide. Developments in the areas of ionisation sources, high-resolution mass analysers, tandem mass spectrometry, and ion mobility have significantly extended the repertoire of mass spectrometrists, however for coordination compounds and supramolecules, mass spectrometry remains underexplored and arguably underappreciated. Here, the reader is guided through different tools of modern electrospray ionization mass spectrometry that are suitable for larger inorganic complexes. All steps, from sample preparation and technical details to data analysis and interpretation are discussed. The main target audience of this tutorial are synthetic chemists as well as technicians/mass spectrometrists with little experience in characterising labile inorganic compounds.
Basic Ecclesial Communities
Authors: Rayappan Arockia
Published: April 2024

Religious intolerance and blatant polarization along the lines of caste, colour, and racial differences are on the rise in India, a trend that has been compounded by the explicit religious nationalism of the incumbent ruling party, the Bharatiya Janata Party (BJP). In the face of this rising intolerance and polarization, a substantial number of Indians from different demographics have begun to envision and participate in people-centred initiatives to nurture religious and social harmony. The present article proposes that Basic Ecclesial Communities – a practical, resourceful, and sustainable means of fostering community and religious harmony through interfaith sharing, hospitality, and a welcoming mindset – represent an impactful contribution to this effort.
The study of antioxidant compounds in grape seeds
Authors: Arava Vidyadhari , Tummala Pavani , Bandi Divya Sree , Mangala Teja Divya , Porumamilla Ram Prathap Goud , V Ashok Kumar , Tatiparthi Siva Prasad , KV Swathi Krishna
Published: April 2024

This paper uses spectrometric as well as chromatographic techniques to investigate the antioxidant properties of extracts from vine seeds (Vitis vinifera L.). For the study, ten vine varieties from the years 2015, 2016, along with 2017 were chosen. Four essentially distinct spectrophotometric methods were used to measure the antioxidant activity, whereas the Folin-Ciocalteu procedures were used to determine the level of total polyphenolic compounds. The composition of fourteen antioxidants was investigated in 2015. The study's findings indicate that grape seeds have a high level of antioxidant components, with variations in content between types and years. Grape seed extracts have potential applications in nutraceuticals, health supplements, as well as food product preservation.
A Cross-sectional Study Assessing the Prevalence of Depression among Medical Undergraduates and Interns of Bangalore Medical College and Research Institute, Bengaluru
Authors: R Krishnan Sini , G Sahanashree , Priya Mathew C Anu , T S Ranganath , Selvi Thangaraj Dr.
Published: April 2024

Background Depression is a common illness worldwide with an estimated 3.8 of the population affected. Medical profession is always associated with different kinds of stressors physically and mentally. This study was undertaken to assess the prevalence of depression among medical students and to determine its contributing factors.Methodology It is a cross-sectional questionnaire based study. Around 200 students were selected using systematic random sampling from all the years i.e. 1st year medical students to interns. Patient health questionnaire-9 was used to assess the prevalence of depression.Results A total 207 students participated in the study including 137 males and 70 females. An overall prevalence of depression was found to be 33.3.Conclusion The prevalence of depression was found to be 33.3. This calls for a need to change the working conditions or working hours of resident doctors favorably not just to enhance productivity but also to promote their overall mental health.
Symptomology Following First Dose of COVID-19 Vaccination in Healthy Subjects without Comorbidities
Authors: B Rotti Premalata , C Belgavimath Sangeeta , BM Sunil
Published: April 2024

Introduction Since the time of inception of vaccines for prevention of deadly diseases their pros and cons have been seriously discussed among scientific fraternity. Pandemic like COVID-19 is a potential threat for human race and vaccination is one of the major preventive tools to safe guard population. But every vaccine has some or the other side effects. Hence extensive scientific research is needed to ascertain the immediate symptoms developed after the administration of vaccine. Considering this challenge the present study was a sincere attempt to explore the symptomatology after the administration of first dose of COVID-19 vaccination within a month amongst the subjects without co-morbidities.Methodology An observational study was conducted for about an year and the data was collected using Google forms.Results A total sample of 397 participants were selected out of which 23 subjects had co-morbidities. Hence the final sample included was 375. Among them 236 63 were females and 139 37 were males. Around 47 12.5 subjects received Covaxine 328 87.5 received Covishield. About 56 15 subjects suffered with COVID-19 before receiving the 1st dose of vaccination. 74 19.7 subjects suffered with symptoms other than the listedreported symptoms after vaccination. After vaccination 310 82.6 subjects developed pain at the site of injection 55 14.6 developed body ache 52 13.9 developed fever with body ache and 38 10.1 developed only fever.Conclusion After receiving vaccination 164375 43.7 subjects developed symptoms after the first day following vaccination and the rate of development of symptoms was maximum in subjects in the age range of 23-27 years while it was minimum in subjects aged above 58 years. Majority developed fever in association with other symptoms 216 57.5.
Selection parameters in lines of Drosophila melanogaster Meig., obtained from populations living in territories with different levels of radiation pollution: approbation of the Crow’s method
Authors: Lukianov M. , Zlatiev A. , Vakulenko E. , Skorobagatko D. , Mazilov A. , Strashnyuk V.
Published: April 2024

Man-made disasters, such as the accidents at the Chornobyl NPP and the Fukushima NPP-1, have raised questions about the radiation risks associated with the use of atomic energy in a new and acute way. The purpose of the study was to investigate the features of the action of natural selection in the lines of Drosophila melanogaster Meig., obtained from natural populations living in territories with different levels of radiation pollution. One of the aims was to test Crow's method on a model object, such as Drosophila. This method makes it possible to estimate the total intensity of selection, as well as to determine the contribution of its individual components, such as differential fecundity and differential mortality. The study was carried out on three lines of Drosophila melanogaster Meig.: the Haidary line (radiation background in the territory from which the line originates: 0.12 μSv/h, β-radiation flux: 0 particles/cm2/min), the KhPTI line (radiation background: 0.12–0.20 μSv/h, β-radiation flux: 0 particles/cm2/min), the Chornobyl line (radiation background: 0.20–0.22 μSv/h, β-radiation flux: 7–8 particles/cm2/min). According to the obtained results, the lines did not differ among themselves in egg production of females. In terms of the number of adult offspring, the Chornobyl line was inferior to the Haidary and KhPTI lines by 48.9% and 57.8%, respectively. Mortality in the pre-reproductive period of development (indicator pd), which includes embryonic and pupal mortality, was the highest in the Chornobyl line and exceeded the pd value in the Haidary and KhPTI lines by 1.4 times. As a result, the Chornobyl line, obtained from the territory contaminated with radionuclides, significantly exceeded the Haidary and KhPTI lines, obtained from the territories where the radiation situation does not go beyond the norm, by both components of selection – both by the component of differential fecundity (If), and by differential mortality (lm). The total selection indices (Itot) were quite close in the Haidary and KhPTI lines, and in the Chornobyl line this index was 2,1–2,6 times higher than in the other two lines. The results of the study support the view that ionizing radiation can promote evolution by accelerating evolutionary change. They indicate an increased mortality rate, a reduced level of fitness and an increased selection pressure in the line of fruit flies, which originates from the population living in the radiation-contaminated territory in the Chornobyl exclusion zone.
Research on the Evaluation of the Implementation Effect of Curriculum Examination Reform: Taking the Course of “Introduction to Language” as an Example
Authors: Yi Qianwen
Published: April 2024

“Introduction to Language,” as the core course of the English major, mainly reveals the basic laws of language, enabling the students to have the ability to apply linguistic theories to explain language phenomena and solve specific language problems. This course is highly theoretical and has a certain degree of difficulty. The evaluation of student grades has always been based on examination reform, but several problems have been encountered during the implementation process. This article analyzes the current situation of the reform and implementation of the “Introduction to Language” course examination in applied universities and puts forth suggestions and specific measures to improve the assessment of the course, aiming to enhance the teaching effectiveness of the course and scientifically and comprehensively evaluate students’ abilities.
Anais da XV Jornada da Residência Médica da Universidade Federal do Piauí e IV Jornada Científica da Residência Multiprofissional do Hospital Universitário e da Universidade Federal do Piauí
Authors: HU-UFPI Hospital Universitário
Published: April 2024

Em sua décima quinta edição, a Jornada Científica da Residência Médica, juntamente com a quarta Jornada Científica da Residência Multiprofissional do Hospital Universitário e da Universidade Federal do Piauí, trazem consigo a concretização de mais uma etapa na carreira profissional dos então residentes que agora serão diplomados em um dos 34 programas de residência médica, multi e uniprofissional ofertados pelo HU-UFPI/Ebserh. Nessa Jornada, os profissionais de saúde que estão concluindo seus programas de residência apresentarão pesquisas científicas de excelente qualidade, que retratam a excelência do ensino e da pesquisa científica na UFPI, contribuindo também para divulgar os programas de residência e seus avanços. Convidamos a todos para participarem da XV Jornada Científica da Residência Médica da UFPI e IV Jornada Científica da Residência Multiprofissional do Hospital Universitário e da Universidade Federal do Piauí e prestigiarem os novos profissionais especialistas oriundos da nossa Instituição. Agradecemos a colaboração de todos que estiveram e continuam envolvidos com as Residências Médicas e Multiprofissional do HU UFPI.
Functional characteristics of distributive repetition verbs in the work “Dark Alleys” by Ivan Bunin
Authors: Lu P.
Published: April 2024

The article describes function specifics of distributive repetition verbs in the work “Dark Alleys” by Ivan Bunin. The author analyzes both the paradigmatic and syntagmatic characteristics of verbs in a certain context, which makes it possible to identify both the vocabulary changes under the influence of context, various kinds of meaning increments and the idiosyncrasies of the writer. The purpose of the work is to investigate the functions of distributive repetition verbs with the prefixes rac/ras-, pere-, s- taking into account both individual characteristics and the specifics of the verb class to establish the specifics of the author’s idiosyncrasy. The article concludes that the semantics of the verbs with the considered prefixes determines their linguistic behavior in a particular text. We have established that the verb word multiplicity is motivated both by the type of the verb and its communicative rank and taxonomic class. The major feature of our research is that we consider distributive repetition verbs in a certain context, revealing their textual characteristics and their role in revealing the author’s intention. We use the descriptive method in our research, focusing on the contextual analysis of distributive repetition verbs. In addition, in the process of our research into the functional-semantic field of distributive repetition, we used the functional-semantic and stylistic methods of analysis, considering the functions of plurality verbs at different language levels.
Identifying the Severity of Criminal Activity in Society Using Picture Fuzzy Baire Space
Authors: Tamilselvan K. , Visalakshi V.
Published: April 2024

In this paper, the idea of picture fuzzy Baire space is explored and its properties are examined. The features of picture fuzzy semi-closed and semi-open sets, picture fuzzy nowhere dense sets, picture fuzzy first and second category sets, picture fuzzy residual sets, picture fuzzy submaximal spaces, picture fuzzy strongly irresolvable spaces, picture fuzzy Gδ set, picture fuzzy Fσ set, and picture fuzzy regular closed sets are analyzed. To understand the concepts, some examples are provided. An algorithm using picture fuzzy Baire space is developed to address real-world scenarios. This method is more effective in assessing criminal activity as it identifies an individual who has committed a more serious offense. This algorithmic approach proves its effectiveness in navigating the complexities of practical examples, showcasing its potential for real-world applications.
Electricity Theft Detection Using Rule-Based Machine Leaning (rML) Approach
Authors: Bahrami Sheyda , Yumuk Erol , Kerem Alper , Topçu Beytullah , Kaya Ahmetcan
Published: April 2024

Since electricity theft affects non-technical losses (NTLs) in power distribution systems, power companies are genuinely quite concerned about it. Power companies can use the information gathered by Advanced Metering Infrastructure (AMI) to create data-driven, machine learning-based approaches for Electricity Theft Detection (ETD) in order to solve this problem. The majority of data-driven methods for detecting power theft do take usage trends into account while doing their analyses. Even though consumption-based models have been applied extensively to the detection of power theft, it can be difficult to reliably identify theft instances based only on patterns of usage. In this paper, a novel rule-based combined machine learning (rML) technique is developed for power theft detection to address the drawbacks of systems that rely just on consumption patterns. This approach makes use of the load profiles of energy users to establish rules, identify the rule or rules that apply to certain situations, and classify the cases as either legitimate or fraudulent. The UEDAS smart business power consumption dataset's real-world data is used to assess the performance of the suggested technique. Our technique is an innovation in theft detection that combines years of intensive theft tracking with the use of rule-based systems as feature spaces for traditional machine learning models. With an astounding 93% recall rate for the rule-based feature space combination of the random forest classifier, this novel approach has produced outstanding results. The acquired results show a noteworthy accomplishment in the field of fraud detection, successfully detecting fraudulent consumers 77% of the time during on-site examination.
Development of Russia’s industry: Some regularities and prospects
Authors: Sukharev Oleg
Published: April 2024

Industry is the substratum of material production and the economy as a whole. Numerous discussions about the need for new industrialisation make us turn again to the analysis of the state of industrial potential and results of industrial development in Russia. The study aims to explain the performance of the Russian industry in terms of the most relevant and aggregated indicators characterising its functioning, and to formulate its long-term development tasks. The methodological basis of the study is the theory of industrial development. Methods of planning and industrial analysis are used. The evidence is the data for 2012–2022 retrieved from the Federal State Statistics Service of the Russian Federation and the Unified Interdepartmental Statistical Information System. The research concludes about the ‘contracted’ development of the Russian industry. The growth rate of the gross value added is more significantly impacted by the dynamics of fixed capital rather than that of labour. Yet the labour contributed greatly to the creation of the new value, which indicates the predominance of labour-intensive technologies, or obsolete capital-intensive technologies. The study empirically confirms that some periods saw a ‘paradox of rapid industrialisation’, that is, a substantially lower rate of economic growth against a higher growth of industry and modernisation of its fixed assets. The general conclusion is that when conducting industrial policy, it is necessary to influence the state of the labour and capital factors in the manufacturing sectors. The industrialisation of the Russian economy needs to be oriented towards the technological substitution through the creation of new fixed assets; in addition, the losses of greatly reduced labour potential should be compensated. A promising avenue is the organisation of analytical planning for the state-owned industry and indicative planning for private industries along with the adoption of a law on the state sector.
Institutional barriers to the development of small-scale power generation in Russia
Authors: Kozhevnikov Mikhail , Dvinyaninov Artem , Sapozhnikov Nikita
Published: April 2024

The energy strategy of Russia involves a transition to a diversified energy generation characterised by a structural diversity of plant types, as well as the use of small-scale energy technologies. The purpose of the study is to identify the barriers that hinder the implementation of small-scale power generation in the Russian Federation and justify the avenues for its development. Methodologically, the paper relies on the systems approach. Methods of content and logical structural analysis, in-depth interviews are applied. The empirical evidence comes from analytical reports, normative and legal documents, as well as results of surveys of 96 specialists in the field and heads of power plants and power engineering enterprises conducted during 2021– 2023. The findings indicate there are four groups of problems in the Russian energy system: technological backwardness; difficulties with integration of small-scale power generation facilities into the energy market; absence of state support mechanisms; surplus of power generation capacity. Accordingly, the paper provides recommendations for overcoming them, in particular, it is necessary to introduce mechanisms for the support of small-scale power engineering and integration with engineering and consultancy companies, as well as make use of energy service agreements; second, to introduce standards for connecting small-scale power generation facilities, develop guidelines for designing and commissioning them; third, to amend tax regulations and learn from successful foreign experience; fourth, to replace retired power generation equipment with new small-scale power generation facilities located closer to load centres. The theoretical significance of the research is linked with detailing the concept “small-scale power generation” as a segment of energy sector as well as its structure in relation to the Russian Federation, specifying classification characteristics of low-capacity power units. The findings are practically valuable for government authorities, power generation enterprises and equipment manufacturers due to the developed organisational and methodological guidelines.
ANÁLISE DA QUEDA NA COBERTURA VACINAL DE TÉTANO POR REGIÃO BRASILEIRA DE 2012 A 2022
Authors: Avila Nathalia de Medeiros , Gomes Nicolly Quintanilha , Bento Mariana Luiza Takeuchi , Severo Jemima Caetana , Silva Natália Valente da
Published: April 2024

Introdução: O tétano é uma infecção bacteriana grave, desencadeada pela Clostridium tetani. É, porém, imunoprevenível e sua profilaxia se dá através da vacina, sendo essa o principal método de combate
INTEGRAÇÃO DA INTELIGÊNCIA ARTIFICIAL NOS DISPOSITIVOS MÉDICOS COMO SUPORTE ÀS EMERGÊNCIAS CARDÍACAS
Authors: Martins Marcelo
Published: April 2024

A convergência entre inteligência artificial e dispositivos médicos redefine a abordagem às emergências cardíacas. A aplicação de algoritmos avançados possibilita análise em tempo real, monitoramento
CARDIOVERSÃO POR ABLAÇÃO NA SÍNDROME DE WOLFF-PARKINSON-WHITE: ESTRATÉGIAS EMERGENCIAIS E PERSPECTIVAS PARA A ESTABILIZAÇÃO CARDÍACA
Authors: Martins Marcelo
Published: April 2024

O estudo destaca a crucial importância do manejo emergencial na Síndrome de Wolff-Parkinson-White (WPW), caracterizada por vias acessórias cardíacas anômalas e risco significativo de arritmias graves.
MANEJO ADEQUADO DE CONTROLE DA HIPONATREMIA PARA PREVENÇÃO DA MIELINÓLISE PONTINA
Authors: Martins Marcelo , Tamer João Thomaz Costa
Published: April 2024

A mielinólise pontina é uma condição neurológica grave associada frequentemente à hiponatremia. Este estudo foca no manejo adequado para prevenir a mielinólise pontina, com ênfase nas estratégias cruc
O PAPEL DA MEDICINA DE EMERGÊNCIA E DOS CUIDADOS DE FIM DE VIDA EM PACIENTES COM NEOPLASIA PULMONAR
Authors: Lima Giovanna Caixeta de , Costa Deboráh Cristina Silva , Carmo Jean Frederico Falcão do
Published: April 2024

O câncer de pulmão é atualmente a principal causa de morte por câncer em homens e a segunda principal
entre as mulheres. Devido a sua alta prevalência, visitas ao pronto socorro por pacientes com esse
GARGALOS DA INFRAESTRUTURA LOGÍSTICA DO BRASIL E O IMPACTO NO COMÉRCIO EXTERIOR
Authors: SANTOS ANGELICA DA SILVA , Baptista José Abel de Andrade
Published: April 2024

A logística é fundamental para a eficiência do comércio exterior e pode ser considerada a principal variável nesse contexto. Cada vez mais, ela desempenha um papel crucial nas relações comerciais, tanto nacionais quanto internacionais, possibilitando o desenvolvimento econômico e promovendo a competitividade em um mercado global. No contexto brasileiro, onde o transporte rodoviário é o meio predominante de transporte de cargas, os altos custos deste modal em relação aos demais, agravados pela precariedade das rodovias e falta de investimentos nos outros modais, acabam criando gargalos logísticos. Este estudo tem por objetivo apresentar as falhas logísticas no Brasil, país com dimensões continentais com gargalos de infraestrutura ainda presentes, que propulsionam o principal obstáculo do setor produtivo nacional, a logística. A apuração comprobatória deste objetivo se deu através da utilização de dados secundários, pesquisas cientificas qualitativas acadêmicas, literatura bibliográfica, artigos, livros e sites.