bluuebunny/crossref_metadata_2025 huggingface dataset:
TomocuPy – efficient GPU-based tomographic reconstruction with asynchronous data processing
Authors: Nikitin Viktor
Published: November 2022

Fast 3D data analysis and steering of a tomographic experiment by changing environmental conditions or acquisition parameters require fast, close to real-time, 3D reconstruction of large data volumes. Here a performance-optimized TomocuPy package is presented as a GPU alternative to the commonly used central processing unit (CPU) based TomoPy package for tomographic reconstruction. TomocuPy utilizes modern hardware capabilities to organize a 3D asynchronous reconstruction involving parallel read/write operations with storage drives, CPU–GPU data transfers, and GPU computations. In the asynchronous reconstruction, all the operations are timely overlapped to almost fully hide all data management time. Since most cameras work with less than 16-bit digital output, the memory usage and processing speed are furthermore optimized by using 16-bit floating-point arithmetic. As a result, 3D reconstruction with TomocuPy became 20–30 times faster than its multi-threaded CPU equivalent. Full reconstruction (including read/write operations and methods initialization) of a 20483 tomographic volume takes less than 7 s on a single Nvidia Tesla A100 and PCIe 4.0 NVMe SSD, and scales almost linearly increasing the data size. To simplify operation at synchrotron beamlines, TomocuPy provides an easy-to-use command-line interface. Efficacy of the package was demonstrated during a tomographic experiment on gas-hydrate formation in porous samples, where a steering option was implemented as a lens-changing mechanism for zooming to regions of interest.
2,5,8,11-Tetramethyl-2,5,8,11-tetraazadodecane-2,11-diium bis[hydroxytris(pentafluorophenyl)borate] benzene 2.5-solvate
Authors: Butcher Ray J. , Purdy Andrew P.
Published: November 2022

The title compound of overall stoichiometry, C12H32N4
2+·2C18HBF15O−·2.5C6H6, crystallizes in the triclinic space group P\overline{1} and the stoichiometry of the asymmetric unit consists of two [C12H32N4]2+ dications, two [C18HBF15O]− anions, and 2.5 molecules of benzene as solvate. The dications are both at half occupancy and located on a center of inversion, as is one of the benzene solvate molecules. In the two anions the O—H groups participate in different hydrogen-bonding schemes. In anion A, the OH group participates in a bifurcated 2R
2
2(6) scheme with F atoms on different rings of an adjacent hydroxy[tris(pentafluorophenyl)]borate moiety with an additional N—H...O hydrogen bond with a dication. For anion B, the OH group participates in a single O—H...F R
2
2(6) scheme. In addition, there are both O—H...N and N—H...O hydrogen bonds involving dication D and anion B in an R
2
2(7) motif. There are numerous C—H...π interactions between the dications and all the three benzene solvate molecules. For solvate 3, the C—H...π interactions are on both sides of the benzene ring and link both dications and solvate into a linear chain in the c-axis direction.
Impact of digital Industry 4.0 innovations on interorganizational value chains: a systematic literature review
Authors: Nottbrock Claus , Van Looy Amy , De Haes Steven
Published: November 2022

Purpose

Organizations invest in novel digital innovations to improve their business processes. These innovations, including Industry 4.0 technologies, enable full organizational integration with business process management (BPM), thereby requiring interorganizational relationship (IOR) capabilities. Many organizations lack knowledge about areas of interorganizational (IO) capability for integrating digital innovations into their value chains. They therefore have difficulty understanding that, as a socio-technical concept, digitalization surpasses the intraorganizational level and requires tools to develop mandatory IOR capabilities. The authors’ systematic literature review (SLR) explores these capabilities within the discipline of BPM. The purpose of this paper is to address this issue.

Design/methodology/approach

This SLR follows the standard methodology for structuring a broad research field. The authors assessed capabilities relevant to manufacturing organizations from 58 academic articles published between 2011 and 2021.

Findings

Building on existing firm-centric capability frameworks, the authors developed individual capabilities into a novel framework of digital interorganizational value chain (DIOVC). The authors’ conceptual model provides a basis for researchers and practitioners to consider capabilities and the theoretical spectrum of IO value chains.

Research limitations/implications

Future studies should validate these DIOVC capabilities as input for an updated model of BPM maturity aimed at improving business process performance through digital innovations.

Practical implications

This study provides organizations with IOR knowledge, supports decision makers in governing digital innovations and develops IO capabilities to improve their value chain performance.

Originality/value

The authors’ DIOVC capability framework is robust, with constructs and dimensions grounded in the literature, demonstrating theoretical and practical relevance.
Industry 4.0 driven emerging skills of offsite construction: a multi-case study-based analysis
Authors: Ginigaddara Buddhini , Perera Srinath , Feng Yingbin , Rahnamayiezekavat Payam , Kagioglou Mike
Published: November 2022

Purpose

Industry 4.0 is exacerbating the need for offsite construction (OSC) adoption, and this rapid transformation is pushing the boundaries of construction skills towards extensive modernisation. The adoption of this modern production strategy by the construction industry would redefine the position of OSC. This study aims to examine whether the existing skills are capable of satisfying the needs of different OSC types.

Design/methodology/approach

A critical literature review evaluated the impact of transformative technology on OSC skills. An existing industry standard OSC skill classification was used as the basis to develop a master list that recognises emerging and diminishing OSC skills. The master list recognises 67 OSC skills under six skill categories: managers, professionals, technicians and trade workers, clerical and administrative workers, machinery operators and drivers and labourers. The skills data was extracted from a series of 13 case studies using document reviews and semi-structured interviews with project stakeholders.

Findings

The multiple case study evaluation recognised 13 redundant skills and 16 emerging OSC skills such as architects with building information modelling and design for manufacture and assembly knowledge, architects specialised in design and logistics integration, advanced OSC technical skills, factory operators, OSC estimators, technicians for three dimensional visualisation and computer numeric control operators. Interview findings assessed the current state and future directions for OSC skills development. Findings indicate that the prevailing skills are not adequate to readily relocate construction activities from onsite to offsite.

Originality/value

To the best of the authors’ knowledge, this research is one of the first studies that recognises the major differences in skill requirements for non-volumetric and volumetric OSC types.
Modeling and simulation of an ultra-low frequency and low-pressure resonator
Authors: Eidi Amin
Published: November 2022

Purpose

Detection of low-frequency pressures such as heart rate in the range of 1 Hz is one of the applications of low-frequency resonator. In this paper, the structure of the resonator is in the form of a plate, whose mathematical model has been extracted according to past works and is reported.

Design/methodology/approach

This paper presents an electromechanical microresonator that can be used as an ultra-low-frequency pressure sensor. It is very important to choose the right material for the sensors to have the optimal conditions. In this work, by proposing the innovative use of polytetrafluoroethylene material with low stiffness coefficient, the necessary conditions are provided to reduce the vibration frequency of the resonator.

Findings

The proposed design is simulated with the help of COMSOL, and its results are compared with the results of the mathematical model, which are very close to each other. Therefore, by inferring the results, the authors can rely on accurate simulations and finalize the similar designs with full confidence before fabrication.

Originality/value

There are important advantages regarding the geometry of the proposed design structure that is the possibility of detecting a pressure of 1 Pa only with voltages less than 2 V. On the other hand, the pull-in effect causes very low frequencies to be achieved in detection with the help of the proposed resonator. Also, the linear and nonlinear behavior of the resonator by applying different pressures has been studied and reported to find the appropriate operating range of the resonator and its limitations.
Towards the adoption of most suitable green walls within sustainable buildings using interval type-2 fuzzy best-worst method and TOPSIS technique
Authors: Tabatabaee Sanaz , Ashour Mojtaba , Sadeghi Haleh , Hoseini Seyed Amirali , Mohandes Saeed Reza , Mahdiyar Amir , Ismail Syuhaida , Hosseini M. Reza
Published: November 2022

Purpose

To come up with a prudent decision on the installation of an appropriate green wall (GW) on buildings, this study presents a novel decision-making algorithm. The proposed algorithm considers the importance of barriers hampering GW adoption, as well as their relationships with regard to different types of GWs existing in a contextual setting.

Design/methodology/approach

The proposed methodological approach is based on the integration of qualitative and quantitative techniques by employing focus group discussion, fuzzy-based best-worst method and fuzzy TOPSIS.

Findings

Based on the experiences of qualified experts involved in related projects in Hong Kong, the following conclusions are drawn: (1) cost, installation and maintenance-related barriers are perceived to have the highest importance, (2) modular living wall system is the most suitable GW system for the context of Hong Kong and (3) existing barriers are found to have a pivotal role in the ranking of the most suitable GW systems.

Practical implications

The findings provide valuable insight not only for policymakers and stakeholders, but also for establishing a methodological approach that can assist decision-makers in identifying the most beneficial GW system rather than the most applicable one. This could have significant implications and introduce potential changes to the common way of practice within the industry and lay the foundation for wider adoption of GW.

Originality/value

While previous studies have investigated the sustainability-related issues of GW façade applications, the current body of knowledge is deprived of a comprehensive methodological approach for the selection of the most suitable GW systems.
To make your mouth water or not? How field dependence/independence and occasion-setting cues affect consumers’ food intake intention
Authors: Yao Qi , Tao Xiaofang , Zhou Wenkai
Published: November 2022

Purpose

This study aims to empirically investigate how the interaction effect of occasion-setting cues and consumers’ cognitive styles (e.g. field dependence levels) influences their food intake intention.

Design/methodology/approach

In this research, several scenario simulation studies were conducted to verify the hypotheses. A total of 646 participants were recruited for the experiments, and samples were obtained through well-established online research platforms.

Findings

In the occasion-setting cue advertisement condition, field-dependent (vs field-independent) consumers displayed increased cravings for food and purchase intention, with mental simulation playing a mediating role and cognitive load playing a moderating role.

Research limitations/implications

The influence of others (e.g. servers and other consumers) was not taken into consideration in this study. Future research can extend this study by conducting field experiments.

Practical implications

The research conclusions can help various organisations reduce consumers’ food overconsumption intention and encourage healthier food choices by adjusting occasion-setting cues in marketing stimuli and identifying the target consumers’ cognitive styles.

Originality/value

Based on embodied cognition theory, this study reveals the influence and internal mechanism of the interaction effect between occasion-setting cues and individual cognitive style on eating desire.
Moral exclusion in hospitality: testing a moderated mediation model of the relationship between perceived overqualification and knowledge-hiding behavior
Authors: Shafique Imran , Kalyar Masood Nawaz , Ahmad Bashir , Pierscieniak Agata
Published: November 2022

Purpose

Drawing from moral exclusion theory, this study aims to examine a moderated mediation model for the relationship between perceived overqualification (POQ) and knowledge-hiding behavior directly and via perceived dissimilarity.

Design/methodology/approach

Using the convenience-sampling technique, time-lagged (three waves) data were gathered from 595 employees working in different hotels and event management firms. Hayes’ PROCESS macro was used to test the moderated mediation model.

Findings

Results showed that perceived dissimilarity among coworkers mediated the result of POQ on knowledge-hiding behavior. In addition, interpersonal disliking moderated the indirect effect in a way that this effect was strong when interpersonal liking was low.

Practical implications

Findings suggest that organizations should make the overqualified realize that they can also learn from their coworkers whom they perceive as less qualified. In this, the feelings of dissimilarity and disliking can be minimized that in turn may decrease the intention to hide knowledge.

Originality/value

The present study offers a new perspective for identifying the nexus between POQ and knowledge-hiding behavior by drawing upon moral exclusion theory and examining the mediating role of perceived deep-level dissimilarity.
Human–robot interactions in the restaurant setting: the role of social cognition, psychological ownership and anthropomorphism
Authors: Ruiz-Equihua Daniel , Romero Jaime , Loureiro Sandra Maria Correia , Ali Murad
Published: November 2022

Purpose

The usage of robot waiters in the hospitality industry is growing, thus increasing the number of human–robot interactions in frontline services. Focusing on robot waiters in restaurants, this study aims to propose the social cognition (SC)–psychological ownership (PO)–customer responses (CR) model, while examining the association between SC, PO, robot anthropomorphism and CR.

Design/methodology/approach

The hypotheses of this study are tested using a three-step mixed-method approach that includes partial least squares structural equation modeling (PLS-SEM), necessary condition analysis (NCA) and fuzzy-set qualitative comparative analysis (fsQCA).

Findings

PLS-SEM demonstrates the mediating role of psychological ownership on the relationship between SC, customer attitudes regarding being attended by a robot and revisiting intentions. Robot anthropomorphism enhances the relationship between SC and psychological ownership. NCA indicates that SC and psychological ownership are necessary conditions for the presence of favorable attitudes and revisiting intentions. FsQCA suggests that different configurations of the antecedent conditions lead to better attitudes and revisiting intentions.

Practical implications

Frontline hospitality robots need to be perceived as warm, competent, responsive and adaptable to customer requests to elicit positive responses. Managers should employ attractive robots displaying anthropomorphic features. Managers need to ensure that customers have some knowledge about robots before interacting with them. Managers should also consider customer heterogeneity and the context in which the robots will be deployed.

Originality/value

Based on the psychological ownership theory, this paper analyzes the relationship between SC, psychological ownership and CR. Anthropomorphism moderates the relationship between SC and psychological ownership.
Drivers and barriers in developing sustainability leadership – a case of natural scientists at Ugandan universities
Authors: Lukwago Julius , Martins Ana Maria De Azevedo , Tefera Orthodox
Published: November 2022

Purpose

Although natural science disciplines significantly contribute to sustainable development goals (SDGs), little research attends to how higher education institutions (HEIs) influence the development of leadership skills needed among sustainability leaders. This paper aims to examine the leadership development experiences of natural scientists at the forefront of disciplines associated with SDGs to identify barriers and drivers to sustainability leadership skills development at HEIs.

Design/methodology/approach

A mixed-methods comparative study was used, integrating qualitative interviews among 21 natural scientists and 11 non-scientists, two focus group discussions and a cross-sectional survey of 221 leaders. The theory of planned behaviour was used as the analytical frame to identify themes emerging from the data as facilitators or barriers to leadership development.

Findings

There was a statistically significant difference between scientists and non-scientists in the attitudes, beliefs and perceptions that drive participation in leadership development activities. Attitudes belittling leadership skills, limited integration of leadership skills in medical, engineering and agricultural curricula and a social identity of superior learning efficacy impede natural scientist students at HEIs from engaging in leadership development.

Research limitations/implications

Further research using a larger sample could assess the prevalence and effect of the drivers and barriers on sustainability leadership effectiveness.

Practical implications

Beyond integrating leadership skills in HEIs curricula, the development of sustainability leadership requires deliberate elevation of the value of leadership skills within natural sciences, specifically by addressing attitudes, beliefs and workload challenges that impede scientists’ engagement in co-curricular activities.

Originality/value

Integrating multiple disciplines provides generalised insights into the context of leadership development among natural scientists at HEIs. This study identifies specific drivers and barriers affecting leadership development at HEIs in a developing country setting.
The effects of digital nativity on nonvolitional routine and innovative usage
Authors: Martins Patricia , Picoto Winnie Ng , Bélanger France
Published: November 2022

Purpose

This study explores the differences between digital immigrants (DIs) and digital natives (DNs) in the continuance of routine and innovative information system use.

Design/methodology/approach

A quantitative survey was conducted with two different samples comprising 100 DIs and 152 DNs in mandatory information system use contexts. Data were analyzed with structural equation modeling to examine the hypothesized relationships in the research model.

Findings

Results revealed differences among digital nativity groups. The effect of confirmation of expectations about system use on satisfaction is stronger for DNs whereas the effect on task–technology fit (TTF) is similar in both digital groups. Interestingly, significant differences between digital nativity groups occur in routine use. For DIs, TTF and habit are significant while for DNs, satisfaction significantly affects routine use. The results show no difference between digital native groups regarding innovative use.

Originality/value

This study extends the concept of digital nativity to routine and innovative system use, contributing to an enhanced understanding about the differences in information systems continuance (ISC) based on digital nativity. It also provides a fine-grained discussion of how to classify digital nativity and its impact in working contexts and extends the IS continuance model by considering two types of IS usage.
Toward understanding the self-efficacy of external auditors during COVID-19: empirical testing of traditional sources and virtual audit proficiency
Authors: Baatwah Saeed Rabea , Ali Al-Ansi Ali , Almoataz Ehsan Saleh , Salleh Zalailah
Published: November 2022

Purpose

Auditors’ self-efficacy (SE) represents their level of confidence in improving their audit performance. This may be a crucial factor for auditors to perform effectively during the health crisis of COVID-19. This study aims to build on a social cognitive perspective to assess the SE of auditors during the coronavirus of 2019 (COVID-19) and to anticipate that mastery experience, verbal and social persuasion, vicarious experience, physiological and emotional states and virtual audit are determinants of auditors’ SE during COVID-19.

Design/methodology/approach

Based on data from Saudi Arabia, this study surveyed all auditors using an online questionnaire and collected 193 useful responses. Thus, this study analyzed the data using primary statistical tests and a structural equation model of partial least squares.

Findings

This study observes that auditors feel confident in their ability to perform audit activities as well during COVID-19 as at other times. This study also documents that VEs, physiological and emotional states and virtual audits play significant roles in SE. In further analyses, this study observes that auditors who are affiliated with big4 audit firms moderate the positive association between virtual audit and SE. All these results are verified under several econometrical appraisals and held constant.

Originality/value

This study provides a number of theoretical and practical implications.
Using classroom debates to elicit views on educational reforms
Authors: Hamdan Alghamdi Amani Khalaf , Aldossary Ali , Elhassan Waisi
Published: November 2022

Purpose

This classroom-based qualitative study explored the effectiveness of the debate learning strategy in female postgraduate education in Saudi Arabia, which is implementing its recent national development plan, Vision 2030. Educational reform is key to its transition to a modernized, knowledge-based economy. The debate format was used to elicit views on educational reforms and necessitated forming and articulating well-reasoned arguments and logic.

Design/methodology/approach

At a Saudi Eastern Province university, 13 female postgraduate students (preservice teachers) participated in a student-centered learning environment conducive to debates. Documents prepared for the debate underwent a qualitative content analysis.

Findings

Data were readily classified into five categories: educational reforms should meet 21st century skills, achieve educational outcomes, ensure Saudi Arabia’s knowledge-based economy, prioritize the role of the university and recognize the impact of both teachers and curricula. As key players in the nation’s future, participants affirmed the ongoing need for educational innovation and modernization.

Originality/value

While debates are an authentic part of Arabian heritage, they are less utilized in Saudi higher education settings. Findings affirm that debates are a beneficial learning strategy for bolstering future educators’ participation in Saudi Arabia’s educational reform.
Contemporary challenges in the European pharmaceutical industry: a systematic literature review
Authors: Asad Arif Ibne , Popesko Boris
Published: November 2022

Purpose

The COVID-19 pandemic creates inefficiencies in the health-care system by having devastating consequences. It has demonstrated how inefficiencies in the health system can have a significant impact on social cohesion, economic growth and public confidence in government. The main purpose of this study is to explore the contemporary challenges faced by the pharmaceutical industry in Europe.

Design/methodology/approach

This study used a systematic literature review method and adopted inclusion and exclusion criteria after constructive reviews of articles from Web of Science and Scopus databases along with the ranked journals in the Chartered Association of Business Schools to search the following key terms “challenges in the European pharmaceutical industry” during the period from 2011 to 2022. The terms are set to be searched in the publications’ titles, abstracts and keywords.

Findings

This study reviewed 57 papers, and the systematic review revealed the vulnerability of the European pharmaceutical industry, such as the default patent system, ineffective research and development, debate on the role of alliances, low level of expertise in the European health-care system, pharmaceutical supply chain management and other issues.

Research limitations/implications

This study suggests that future research may explore the challenges of multisectoral and cross-country perspectives to get a better understanding, and for the long-term sustainability of public pharmaceutical spending, new models of enhancing research investments are needed, and Europe can still play a leading role in its tradition structure within capturing innovative ideas.

Practical implications

It provides new useful insights to policymakers, global leaders and managers to devise policies to achieve a performance-oriented culture in their institutions and firms.

Social implications

The pharmaceutical sector has recognized the influence of social determinants of health. It moves toward sustained sound health of people to have a flourishing pharmaceutical sector.

Originality/value

There is an insufficient study on the contemporary challenges of the European pharmaceutical industry. This study presents the argument that earlier studies ignored the contemporary issues facing the European pharmaceutical industry from a comprehensive and wider angle. In addition, the COVID-19 pandemic is a recent occurrence, and it causes inefficiency in the health-care sector, where the pharmaceutical industry plays a crucial role; importantly, this topic is emerging and underresearched in the existing literature. There is also a lack of systematic literature review studies in this field.
Shape memory property of polybutylene adipate-co-terephthalate
Authors: Yu Laiming , Fu Yaqin , Dong Yubing
Published: November 2022

Purpose

The purpose of this study is to investigate the thermomechanical condition on the shape memory property of Polybutylene adipate-co-terephthalate (PBAT). PBAT is a widely researched and rapidly developed biodegradable copolyester. In a tensile test, we found that the fractured PBAT samples had a heat-driven shape memory effect which piqued our interest, and it will lay a foundation for the application of PBAT in new fields (such as heat shrinkable film).

Design/methodology/approach

The shape memory effect of PBAT and the effect of the thermomechanical condition on its shape memory property were confirmed and systematically investigated by a thermal mechanical analyzer and tensile machine.

Findings

The results showed that the PBAT film had broad shape memory transform temperature and exhibited excellent thermomechanical stability and shape memory properties. The shape memory fixity ratio (Rf) of the PBAT films was increased with the prestrain temperature and prestrain, where the highest Rf exceeded 90%. The shape memory recovery ratio (Rr) of the PBAT films was increased with the shape memory recovery temperature and decreased with the prestrain value, and the highest Rr was almost 100%. Moreover, the PBAT films had high shape memory recovery stress which increased with the prestrain value and decreased with the prestrain temperature, and the highest shape memory recovery stress can reach 7.73 MPa.

Research limitations/implications

The results showed that PBAT had a broad shape memory transform temperature, exhibited excellent thermomechanical stability and shape memory performance, especially for the sample programmed at high temperature and had a larger prestrian, which will provide a reference for the design, processing and application of PBAT-based heat shrinkable film and smart materials.

Originality/value

This study confirmed and systematically investigated the shape memory effect of PBAT and the effect of the thermomechanical condition on the shape memory property of PBAT.
Residents’ trust in local government councils in an emerging nation: effect of political efficacy, good governance and performance
Authors: Ab. Rahman Farah Adilla , Mohd Suki Norazah , Mohd Yusof Mohd Idham , Yusof Radduan
Published: November 2022

Purpose

This study aims to explore residents’ trust in local government councils and to examine the effect of political efficacy and good governance on that trust and on the performance of local government councils in an emerging nation.

Design/methodology/approach

Data were analysed using qualitative and quantitative research designs. Firstly, a thematic analysis was performed to explore residents’ trust in local government councils and compare it with the data gathered in the literature review. Thereafter, a partial least squares-structural equation modelling (PLS-SEM) approach was used to investigate the hypothesised linkages.

Findings

The thematic analysis of the face-to-face semi-structured interviews discovered four themes (trust, performance, political efficacy and good governance). Additional analysis of these themes via the PLS-SEM approach revealed good governance to be the most influential factor in promoting residents’ trust in local government councils. Political efficacy was the second most influential factor. Residents expect local government councils’ officers to demonstrate a strong commitment to the rule of law and comply with all relevant laws and regulations.

Practical implications

Local government councils should openly accept residents’ requests and suggestions, be more flexible in policy delivery and be responsive to policy demands given the relatively small constituencies and greater policy latitudes. Multiple avenues should be available for interaction between residents and local government councils in the mission to achieve sustainable urban growth.

Originality/value

This study is unique in that it advances existing research that is lacking in the context of the Malaysian local government council. The result alerts are crucial in that they alert local government councils to the need for high levels of governance and accountability in terms of resident support to gain more trust and confidence.
The potential for learning from good RRI practices and implications for the usefulness of RRI as an umbrella concept
Authors: Forsberg Ellen-Marie , Wittrock Christian
Published: November 2022

Purpose

The purpose of this study is to analyze reported good institutional responsible research and innovation (RRI) practices from an organizational and learning perspective to discuss the usefulness of RRI as a broad umbrella concept.

Design/methodology/approach

This study connects neo-institutional and translation accounts of diffusion to different modes of learning and discusses reported best practices from 12 reports, including in total 23 organizations in the research system worldwide, in light of this theoretical framework. This study categorizes the good practices identified in the reports and discusses how the nature of the practices influences the potential learning from them. The authors then apply the results from the discussion of this study to current policy developments on RRI.

Findings

The two most often mentioned good practices overall are organizational policies and the establishment of organizational units, but the type of good practices recommended differs across the various aspects of the RRI umbrella concept. This diversity within the RRI construct is a practical argument against the effectiveness of RRI as an umbrella concept.

Originality/value

This study is novel in the fact that the authors, building on Wæraas (2020), systematically relate types of good practice to neo-institutional theory and translation perspectives explicitly combined with learning approaches and apply this approach in the field of research organizations. The policy implications from the empirical and theoretical analyses are novel and timely in these early phases of the EU funding framework programme Horizon Europe and can also be relevant for the increasingly important umbrella concept of Open Science.
All-inclusive holiday packages, tourist consumption and spending patterns at tourism destinations
Authors: Cozzio Claudia , Tokarchuk Oksana , Maurer Oswin
Published: November 2022

Purpose

The purpose of this study is to investigate tourist in-destination consumption patterns in the context of bundled holiday packages in different resort categories to identify demand behavior that allows implementing profit-enhancing policies through attractive bundled offers for specific tourist segments.

Design/methodology/approach

This study relies on data gathered in a quasi-experiment to analyze differences in consumption patterns at resort bars over a two-year period (summer 2018 and 2019) before and after the introduction of an all-inclusive soft drinks package.

Findings

The findings inform on bundling strategies according to different degrees of price consciousness and resort category. In particular, guests in upscale resorts are more likely to under-consume items included in a pre-paid bundle and significantly engage in additional spending than economy resort guests.

Originality/value

The quasi-experiment provides the actual in-destination consumption patterns and offering managerial insights and tools to tailor the form and content of bundles according to resort category.
Dostarlimab for recurrent mismatch repair‐deficient endometrial cancer: A cost‐effectiveness study
Authors: Dioun Shayan , Chen Ling , Melamed Alexander , Gockley Allison , St. Clair Caryn M. , Hou June Y. , Khoury‐Collado Fady , Hur Chin , Elkin Elena , Accordino Melissa , Hershman Dawn L. , Wright Jason D.
Published: November 2022

Objective

Patients with recurrent endometrial cancer treated with carboplatin and paclitaxel whose disease progresses have few effective treatment options. Based on promising clinical trial data, the anti‐programmed cell death 1 (anti‐PD‐1) antibody dostarlimab was recently granted accelerated approval for endometrial cancer by the US Food and Drug Administration. We developed a decision model to examine the cost‐effectiveness of dostarlimab for patients with progressive/recurrent deficient mismatch repair (dMMR) endometrial cancer whose disease has progressed with first‐line chemotherapy.

Design

Cost‐effectiveness study.

Population

Hypothetical cohort of 6000 women with progressive/recurrent dMMR endometrial cancer.

Methods

The initial decision point in the Markov model was treatment with dostarlimab, pembrolizumab or pegylated liposomal doxorubicin (PLD). Model probabilities, and cost and utility values were derived with assumptions drawn from published literature. Effectiveness was estimated as average quality‐adjusted life years (QALYs) gained. One‐way, two‐way and probabilistic sensitivity analyses were performed to vary the assumptions across a range of plausible values.

Main outcome measures

The primary outcome was the incremental cost‐effectiveness ratio (ICER).

Results

Pegylated liposomal doxorubicin (PLD) was the least costly strategy, at $55,732, followed by dostarlimab ($151,533) and pembrolizumab ($154,597). Based on a willingness‐to‐pay threshold of $100,000/QALY, PLD was cost‐effective compared with dostarlimab, with an ICER of $331,913 per QALY gained for dostarlimab, whereas pembrolizumab was ruled out by extended dominance (less effective, more costly), compared with dostarlimab. In one‐way sensitivity analyses, dostarlimab was cost‐effective when its cost was reduced to $4905 (52% reduction). These results were robust in a variety of sensitivity analyses.

Conclusions

Dostarlimab is associated with greater survival compared with other treatments for women with recurrent dMMR endometrial cancer. Although the agent is substantially more costly, dostarlimab became cost‐effective when its cost was reduced to $5489 per cycle.
Clinical outcomes of conventional HDR intracavitary brachytherapy combined with complementary applicator‐guided intensity modulated radiotherapy boost in patients with bulky cervical tumour
Authors: Lu Shun , Wang Shubin , Kim Robert Y. , Zhang Jiayu , Wang Xianliang , Wang Weidong , Zhu Guiquan , Zhou Jie , Tan Yan , Tan Mingyu , Li Minglun , Yin Gang , Li Jie , Feng Mei , Lang Jinyi
Published: November 2022

Objective

To investigate the clinical outcomes and toxicity in patients with locally advanced cervical cancer treated with supplementary applicator guided‐intensity modulated radiation therapy (IMRT) based on conventional intracavitary brachytherapy (IC/IMRT).

Design

A retrospective cohort study.

Setting

Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, China.

Population

Large high‐risk clinical target volume (HR‐CTV) volume (>40 ml) at the time of brachytherapy cervical cancer patients were recruited.

Methods

This study is a retrospective analysis of 76 patients with locally advanced cervical cancer (FIGO IIB‐IVA) treated with concurrent chemoradiotherapy followed by IC/IMRT between June 2010 and October 2016. External radiotherapy (45 Gy in 25 fractions) was adminstered with cisplatin chemotherapy treatment before IC/IMRT. The IMRT plan was optimised using the ICBT plan base dose plan by an inverse dose optimisation tool which allows the use of DVH constraints on the total dose of ICBT. A seven‐field gantry angle IMRT plan was devised to avoid hotspots when optimising the boost plan. The prescription dose for HR‐CTV and IR‐CTV were 6 and 5 Gy per fraction for five fractions, respectively.

Results

Mean HR‐CTV was 65.8 ± 23.6 ml at the time of brachytherapy. D90 for HR‐CTV and IR‐CTV were 88.7 ± 3.6 Gy and 78.1 ± 2.5 Gy. D2cc for bladder, rectum, sigmoid and small intestine were 71.8 ± 3.8, 64.6 ± 4.9, 63.9 ± 5.3 and 56.7 ± 8.7 Gy, respectively. Median follow‐up was 85 months (47.9–124.2 months). Five‐year local recurrence‐free survival rate, metastasis recurrence‐free survival rate, disease‐free survival rate and cancer‐special survival rate were 87.6, 82.4, 70.9 and 76.3%, respectively. The grade 1 + 2 gastrointestinal and urinary late toxicities were 15.8 and 21.1%, and grade 3 late toxicities were 3.9 and 5.2%, respectively. Neither acute nor late grade 4 gastrointestinal or urinary toxicities were seen.

Conclusions

The combination of ICBT with an applicator‐guided supplementary IMRT boost achieved excellent local control and overall survival with low toxicity for bulky residual cervical tumour.
High‐pressure pasteurization of low‐acid chilled ready‐to‐eat food
Authors: Inanoglu Sumeyye , Barbosa‐Cánovas Gustavo V. , Sablani Shyam S. , Zhu Mei‐Jun , Keener Larry , Tang Juming
Published: November 2022

The working population growth
have created greater consumer demand for ready‐to‐eat (RTE) foods. Pasteurization is one of the most common preservation methods for commercial production of low‐acid RTE cold‐chain products. Proper selection of a pasteurization method plays an important role not only in ensuring microbial safety but also in maintaining food quality during storage. Better retention of flavor, color, appearance, and nutritional value of RTE products is one of the reasons for the food industry to adopt novel technologies such as high‐pressure processing (HPP) as a substitute or complementary technology for thermal pasteurization. HPP has been used industrially for the pasteurization of high‐acid RTE products. Yet, this method is not commonly used for pasteurization of low‐acid RTE food products, due primarily to the need of additional heating to thermally inactivate spores, coupled with relatively long treatment times resulting in high processing costs.

Practical Application: Food companies would like to adopt novel technologies such as HPP instead of using conventional thermal processes, yet there is a lack of information on spoilage and the shelf‐life of pasteurized low‐acid RTE foods (by different novel pasteurization methods including HPP) in cold storage. This article provides an overview of the microbial concerns and related regulatory guidelines for the pasteurization of low‐acid RTE foods and summarizes the effects of HPP in terms of microbiology (both pathogens and spoilage microorganisms), quality, and shelf‐life on low‐acid RTE foods. This review also includes the most recent research articles regarding a comparison between HPP pasteurization and thermal pasteurization treatments and the limitations of HPP for low‐acid chilled RTE foods.
Can MASCC and CISNE scores predict delays of lung cancer chemotherapy after febrile neutropenia?
Authors: Ono Yoshitaka , Hayama Naoki , Hattori Shigeaki , Ito Yoko , Oguma Tsuyoshi , Sakamaki Fumio , Asano Koichiro
Published: November 2022

Background

Febrile neutropenia (FN) during cancer chemotherapy can lead to morbidity and mortality. The Multinational Association of Supportive Care in Cancer (MASCC) and clinical index of stable febrile neutropenia (CISNE) scores have been widely used to predict the risk of severe medical complications in patients with FN; however, there are few tools for predicting chemotherapy delays or discontinuation after FN.

Methods

Patients admitted to two university hospitals between 2014 and 2018 with a FN diagnosis during the first cycle of chemotherapy for lung cancer were reviewed retrospectively.

Results

Among 539 patients who received 813 courses of chemotherapy for lung cancer, 49 (9%) developed FN during the first treatment cycle. Although all the patients recovered from their primary infection, 19 patients (38.8%) developed serious medical complications, 11 (22.4%) were unable to resume chemotherapy and one (2.0%) declined to resume chemotherapy, and nine (18.4%) died within 90 days. Patients who failed to resume chemotherapy had a lower MASCC score (median 8.5 vs. 17, p < 0.01) and a higher CISNE score (median 3 vs. 1, p < 0.01) at the onset of FN. The specificity to predict the patient who failed to resume chemotherapy was 90% or more with MASCC score ≤9 or CISNE score ≥3, with the sensitivity of 61%. MASCC score ≤ 16 can also be a sensitive indicator with the sensitivity and specificity of 89 and 52%, respectively.

Conclusion

The MASCC and CISNE scores are useful in identifying lung cancer patients who are unable to resume chemotherapy as scheduled after the onset of FN.
From Dilmun to Wādī al‐Fāw: A forgotten desert corridor, c. 2000 BC
Authors: Laursen Steffen Terp , al‐Otaibi Faleh
Published: November 2022

There is a lacuna of knowledge on the inland trade routes across Bronze Age central Arabia, which this article seeks to fill based on new evidence from Wādī al‐Fāw, Saudi Arabia. Contrary to a common belief that interior Southeast Arabia after the Holocene Humid Phase and until the domestication of the dromedary had turned desolate Badlands, this study offers documentation that during the early Bronze Age, a commercial corridor connected the Kingdom of Dilmun on the Arabian Gulf coast with the southern parts of Saudi Arabia, probably Yemen. Seals of Dilmun Type, Dilmun pottery and related burial praxis make up the gist of the evidence from Wādī al‐Fāw. A dry mummification mound burial custom is possibly identified at al‐Fāw and probably Taymāʾ, which contrasts the classic Dilmun mound burial custom. An attempt is made to reconstruct the most likely route that connected Dilmun and Wādī al‐Fāw. The emergence around 2000 BC of this trade network, likely based on donkey trains, closely coincides with the rise of the Kingdom of Dilmun, but surprisingly also with a time when Arabia witnessed unusually arid conditions. Identification of this unexpected ancient corridor should profoundly affect how upcoming models consider linguistic, ideological, genetic, cultural and technological transmission across Bronze Age Arabia.
APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
Authors: Kulminski Alexander M. , Jain‐Washburn Ethan , Philipp Ian , He Liang , Loika Yury , Loiko Elena , Bagley Olivia , Ukraintseva Svetlana , Yashin Anatoliy , Arbeev Konstantin , Stallard Eric , Feitosa Mary F. , Schupf Nicole , Christensen Kaare , Culminskaya Irina
Published: November 2022

Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or jointly as combinations of specific variants. Here, we examined chances to live to older ages, 85 years and older, for carriers of compound genotypes comprised of combinations of genotypes of rs429358 (APOE ɛ4 encoding polymorphism), rs2075650 (TOMM40), and rs12721046 (APOC1) polymorphisms using data from four human studies. The choice of these polymorphisms was motivated by our prior results showing that the ɛ4 carriers having minor alleles of the other two polymorphisms were at exceptionally high risk of Alzheimer's disease (AD), compared with non‐carriers of the minor alleles. Consistent with our prior findings for AD, we show here that the adverse effect of the ɛ4 allele on survival to older ages is significantly higher in carriers of minor alleles of rs2075650 and/or rs12721046 polymorphisms compared with their non‐carriers. The exclusion of AD cases made this effect stronger. Our results provide compelling evidence that AD does not mediate the associations of the same compound genotypes with chances to survive until older ages, indicating the existence of genetically heterogeneous mechanisms. The survival chances can be mainly associated with lipid‐ and immunity‐related mechanisms, whereas the AD risk, can be driven by the AD‐biomarker‐related mechanism, among others. Targeting heterogeneous polygenic profiles of individuals at high risks of complex traits is promising for the translation of genetic discoveries to health care.