bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing plasma L-kynurenine impairs mitochondrial oxidative phosphorylation prior to the development of atrophy in murine skeletal muscle: A pilot study
Authors: Palzkill Victoria R. , Thome Trace , Murillo Ania L. , Khattri Ram B. , Ryan Terence E.
Published: September 2022

Introduction: L-Kynurenine (L-Kyn), a product of tryptophan (Trp) catabolism, has been linked with impairments in walking speed, muscle strength/size, and physical function. The purpose of this pilot study was to develop a dietary model that elevates plasma L-Kyn levels in mice and characterize its impact on muscle health and function.

Methods: Four-month-old C57BL6J male mice were randomized to either a L-Kyn supplemented (150 mg/kg) or chow diet for 10 weeks. Plasma L-Kyn and Trp levels were measured via mass spectrometry. Primary outcomes included assessments of muscle weights, myofiber cross-sectional area (CSA), nerve-stimulated contractile performance, and mitochondrial oxidative phosphorylation (OXPHOS) and hydrogen peroxide (H2O2) production. Additional experiments in cultured myotubes explored the impact of enhancing L-Kyn metabolism.

Results: Mice randomized to the L-Kyn diet displayed significant increases in plasma L-Kyn levels (p = 0.0028) and the L-Kyn/Trp ratio (p = 0.011) when compared to chow fed mice. Food intake and body weights were not different between groups. There were no detectable differences in muscle weights, myofiber CSA, or contractile performance. L-Kyn fed mice displayed reductions in mitochondrial OXPHOS (p = 0.05) and maximal ADP-stimulated respiration (p = 0.0498). In cultured myotubes, overexpression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha prevented atrophy and proteolysis, as well as deficits in mitochondrial respiration with L-Kyn treatment.

Conclusion: Dietary feeding of L-Kyn increases plasma L-Kyn levels and the L-Kyn/Trp ratio in healthy male mice. Mitochondrial impairments in muscle were observed in mice with elevated L-Kyn without changes in muscle size or function. Enhancing L-Kyn metabolism can protect against these effects in culture myotubes.
Enhancing Rubisco gene expression and metabolites accumulation for better plant growth in Ficus deltoidea under drought stress using hydrogen peroxide
Authors: Khandaker Mohammad Moneruzzaman , Jamaludin Rosnah , Majrashi Ali , Rashid Zalilawati Mat , Karim Sarker Mohammad Rezaul , Al-Yasi Hatim M. , Badaluddin Noor Afiza , Alenazi Mekhled Mutiran , Mohd Khamsah Suryati
Published: September 2022

Growth improvement of the medicinal plant,Ficus deltoidea(Mas Cotek) under drought conditions is a vital issue in Malaysia since it is a slow-growing plant and disposed to leaf damage under the stresses of drought. Therefore, investigation was done to examine the outcomes of hydrogen peroxide (H2O2) application onRubiscogene expression and metabolites accumulation of stressedF. deltoideaplants, and thereby to record the changes in leaf histology, photosynthesis, biochemical properties, and the growth of the plant. H2O2at the rates of 0, 5, 10, 15, and 20 mM were foliar sprayed biweekly on the drought stressed plants using a hand sprayer. The application of 20 mM H2O2amplified leaf number, tallness, stomatal conductance, and photosynthetic yield by 143, 24, 88, and 18%, respectively, over the control plant. A reduced transpiration rate and improved chlorophyll fluorescence were also noted in H2O2-treated plants. The treatment produced a greater amount of chlorophylla, total phenols, total flavonoids, sugar content, and antioxidant activities by 1.61-, 1.30-, 1.98-, 1.92-, and 1.53-fold, respectively. Application of 15 mM H2O2enhanced net photosynthetic rate and internal CO2concentrations by 1.05- and 1.25-fold, respectively. Additionally, H2O2treatments promoted stomatal closure, increased stomata size, the number of stomata, improved vein structure, and reduced the damage of the leaf margin and mesophyll cells of drought stressed plants. The application of H2O2also accumulated significantly higher contents of sodium (Na+), calcium (Ca2+), potassium (K+), magnesium (Mg+), and iron (Fe2+) in stressed plants. Although the amount of Arsenic (As+) and Antimony (Sb3+) increased to some extent, the increases were not at a toxic level. The use of H2O2enhanced theRubiscogene expression to a greater level and the ratio ofRubiscoexpression increased up to 16-fold. Finally, thirteen (13) identified and five (5) unmatched volatile compounds with a quality score above 70% were identified by gas chromatography-mass spectrometry (GCMS). The GCMS analysis showed that the foliar application of H2O2accumulates a higher percentage of volatile components in plants which helps to mitigate the negative effects of drought stress. It is concluded that under drought stressed conditions theF. deltoideaplants should be treated with 10–15 mM of H2O2twice a week to improve leaf histology, photosynthesis, the level ofRubiscogene expression and volatile compounds accumulation, and plant growth and development.
Integrated analysis of metabolome and transcriptome reveals the cytoplasmic effects of CMS-D2 on pollen fertility resulting from disrupted lipid metabolism
Authors: Zhang Xuexian , Zhang Meng , Guo Liping , Qi Tingxiang , Tang Huini , Li Yongqi , Zuo Zhidan , Shahzad Kashif , Feng Juanjuan , Zang Rong , Wang Hailin , Qiao Xiuqin , Wu Jianyong , Xing Chaozhu
Published: September 2022

Using cytoplasmic male sterility of Gossypium harknesii (CMS-D2) is an economical and effective method to produce cotton hybrids. However, the detrimental cytoplasmic effects of CMS-D2 on pollen fertility and fiber yields greatly limit the further development of three-line hybrid cotton in China. In this study, an integrated non-targeted metabolomics and transcriptome analysis was performed on mature pollens of maintainer line NB, isonuclear alloplasmic near-isogenic restorer lines NH and SH under two environments. A total of 820 metabolites were obtained, of which lipids and lipid-like molecules were the most, followed by organic acids derivatives, phenylpropanoids, and polyketides. Transcriptome analysis revealed significantly more differentially expressed genes (DEGs) in SH versus NH both in Anyang and Jiujiang, and most of the DEGs were significantly upregulated. Further KEGG analysis showed that most DEGs were enriched in the biosynthesis of unsaturated fatty acids, phenylalanine metabolism, and phagosome. Based on the weighted gene co-expression network analysis, totally 74 hub genes were also identified, of which three transcription factors, i.e., WRKY22, WRKY53, and ARF18 were significantly upregulated in SH and may play a negative regulatory role in pollen development by directly or indirectly regulating the jasmonic acid synthesis and signal transduction. Moreover, we found that the negative effects of CMS-D2 cytoplasm on pollen fertility were mainly due to disturbed lipid metabolism, especially the metabolic balance of unsaturated fatty acids, ultimately resulting in the decline of pollen fertility. Meanwhile, in the presence of CMS-D2 sterile cytoplasm, the cytoplasmic-nucleus interaction effects generated a substantial quantity of flavonoids involved in the fertility restoration process. This study preliminarily clarified some of the reasons for the negative effects of CMS-D2 cytoplasm on pollen fertility, and our results will provide an important theoretical reference for further breeding and improvement of three-line hybrid cotton in the future.
Fuzzy TOPSIS framework for promoting win–win project procurement negotiations
Authors: Yu Chien Chou , Luo Jin Hua
Published: September 2022

In recent years, organizations worldwide have widely applied the project approach in business and value delivery. Negotiation is essential to the success of a project; however, it has not been explored systematically in the project context. A gap remains between knowledge and practical behavior during negotiation settlements throughout projects. Many project procurement (PP) negotiations do not work as expected. This study develops a practical framework using the scientific method to help close the gap and improve PP negotiations. The proposed framework uses the fuzzy TOPSIS (technique for order preference by similarity to ideal solution) method to integrate the PP management process (PPMP) and the three-phase negotiating model. Through this approach, notable variables and potential solutions under uncertain negotiation situations are quantitatively examined in the early stage and managed until the completion of PP. Thus, expected agreements can be obtained in a timely and efficient manner, with negotiating parties committing to implementing what has been agreed on. Such a commitment facilitates win-win outcomes. An example is presented to demonstrate how the proposed framework operates, and practical implications for managers of project-based organizations are offered. This study provides researchers and practitioners with a foundation to study refined models to enhance project negotiations with interdisciplinary integration.
Probiotic dairy products and consumption preferences in terms of sweetness sensitivity and the occurrence of childhood obesity
Authors: Kardas Marek , Staśkiewicz Wiktoria , Niewiadomska Ewa , Kiciak Agata , Bielaszka Agnieszka , Fatyga Edyta
Published: September 2022

Fermented dairy products such as yogurt contain many bioactive compounds. In addition, probiotic yogurts are an invaluable source of probiotic bacteria and are a group of probiotic products best accepted by children. There is plenty of research indicating an interdependence between yogurt consumption, body mass index, and adipose tissue percentage, which suggests that yogurt consumption may contribute to reducing the risk of becoming overweight or obese. In turn, the occurrence of overweight and obesity may be accompanied by a reduced sensitivity to sweetness, which modifies food preference selection and acceptance, including with yogurt. This study aimed to assess the preferences and consumption of yogurt in terms of sensitivity to recognize sweetness and obesity in a group of 7–9-year-old children. Body mass index and adipose tissue percentage obesity indicators were determined, and the frequency of fermented milk product consumption was assessed about the results of the sweetness recognition test as well as yogurt preferences. There was no significant relationship between body weight and the frequency of fermented milk product consumption. Correlations were found between the values of body mass index and the ability to recognize sweetness, which was significantly better recognized by underweight children or at normal body weight, moreover, those children with a higher ability to recognize sweetness significantly more frequently preferred plain unsweetened yogurt.
On AI Approaches for Promoting Maternal and Neonatal Health in Low Resource Settings: A Review
Authors: Khan Misaal , Khurshid Mahapara , Vatsa Mayank , Singh Richa , Duggal Mona , Singh Kuldeep
Published: September 2022

A significant challenge for hospitals and medical practitioners in low- and middle-income nations is the lack of sufficient health care facilities for timely medical diagnosis of chronic and deadly diseases. Particularly, maternal and neonatal morbidity due to various non-communicable and nutrition related diseases is a serious public health issue that leads to several deaths every year. These diseases affecting either mother or child can be hospital-acquired, contracted during pregnancy or delivery, postpartum and even during child growth and development. Many of these conditions are challenging to detect at their early stages, which puts the patient at risk of developing severe conditions over time. Therefore, there is a need for early screening, detection and diagnosis, which could reduce maternal and neonatal mortality. With the advent of Artificial Intelligence (AI), digital technologies have emerged as practical assistive tools in different healthcare sectors but are still in their nascent stages when applied to maternal and neonatal health. This review article presents an in-depth examination of digital solutions proposed for maternal and neonatal healthcare in low resource settings and discusses the open problems as well as future research directions.
Physics in the mesosphere/lower thermosphere: A personal perspective
Authors: Lübken Franz-Josef
Published: September 2022

The scope of this paper is to present some progress being made in the last few decades regarding some aspects of physical processes in the mesosphere/lower thermosphere and to point to some open questions. This summary is presented from a personal perspective, i.e., this is not a review of a certain science topic. Most citations reflect my own work or are representative examples only. They are not meant to be complete or comprehensive.
Solar wind magnetosonic mach number as a control variable for energy dissipation during magnetic storms
Authors: Bagheri Fatemeh , Lopez Ramon E.
Published: September 2022

During the main phase of many magnetic storms the solar wind Mach number is low and IMF magnitude is large. Under these conditions, the ionospheric potential saturates, and it becomes relatively insensitive to further increases in the IMF magnitude. On the other hand, the dayside merging rate and the potential become sensitive to the solar wind density. This should result in a correlation between the intensity of the auroral electrojets and the solar wind density. In this study we provide a sample of 314 moderate to strong storms and investigate the correlation between Dst index and the energy dissipated in the ionosphere. We show that for lower Mach numbers, this correlation decreases. We also show that the ionospheric indices of the storms with the lower Mach number are less correlated to the geoeffectiveness of the solar wind during these storms.
Farm-related determinants of food insecurity among livestock dependent households in two agrarian districts with varying rainfall patterns in Ghana
Authors: Nuvey Francis Sena , Nortey Priscillia Awo , Addo Kennedy Kwasi , Addo-Lartey Adolphina , Kreppel Katharina , Houngbedji Clarisse Abikpo , Dzansi Gladys , Bonfoh Bassirou
Published: September 2022

Background

Despite availability of sufficient arable land, many African countries continue to dawdle in agricultural productivity due to over-reliance on rainfall patterns. Thus, undernourishment levels are disproportionately high in Africa. Even though they play key roles in agricultural production, the food security (FS) levels of livestock dependent households are understudied. Our study assessed the FS level and its determinants in livestock farming households in Ghana.

Methods

We compared the FS levels of 287 cattle producing households in two representative agrarian districts with varying rainfall patterns in Ghana (dry vs. wet), using a cross-sectional survey. We assessed household's FS using the Food Insecurity Experience Scale. FS scores and categories were computed, and using generalized linear models, we assessed factors that explained variations in the FS levels among households.

Results

The median herd size of households was 31 cattle (lower quartile = 24, upper quartile = 60 cattle), with a majority (91%) engaged in crop cultivation. Households reported experiencing an average of eight adverse events over a five-year recall period (2014–2018) mainly from animal diseases, cattle theft, and pasture shortages. Most households (81%) were food insecure (moderate = 40%, severe = 41%). In an adjusted model, households raising cattle in the dry district [adjusted Odds Ratio (aOR) = 5.43, 95% CI: 1.94, 15.2] and being married (aOR = 9.48, 95% CI: 2.35, 38.3) were associated with moderate food insecurity. While households raising cattle in the dry district [adjusted Odds Ratio (aOR) = 4.17, 95% CI: 1.44, 12.0], being married (aOR = 3.55, 95% CI: 1.03, 12.2), and increase in number of adverse events experienced (aOR = 1.53, 95% CI: 1.20, 1.96), were associated with increased odds of severe food insecurity. Household's odds of severe food insecurity decreased with each additional head of cattle in their herds (aOR = 0.97, 95% CI: 0.96, 0.99). We find no evidence of effect modification by farming district on other predictor's effect on food insecurity.

Conclusion

Most of the livestock dependent households are food insecure. The food insecurity levels are worse for households farming in dry areas, those married and who experience increased frequency of adverse events. Government policy interventions focusing on maintaining healthy, secure, and productive animal herds would contribute to improving the productivity of household herds, food safety and food security.
Molecular epidemiological survey of porcine epidemic diarrhea in some areas of Shandong and genetic evolutionary analysis of S gene
Authors: Shen Yesheng , Yang Yudong , Zhao Jun , Geng Ningwei , Liu Kuihao , Zhao Yiran , Wang Fangkun , Liu Sidang , Li Ning , Meng Fanliang , Liu Mengda
Published: September 2022

Responsible for the acute infectious disease porcine epidemic diarrhea (PED), PED virus (PEDV) induces severe diarrhea and high mortality in infected piglets and thus severely harms the productivity and economic efficiency of pig farms. In our study, we aimed to investigate and analyze the recent status and incidence pattern of PEDV infection in some areas of Shandong Province, China. We collected 176 clinical samples of PED from pig farms in different regions of Shandong Province during 2019–2021. PEDV, TGEV, and PORV were detected using RT-PCR. The full-length sequences of positive PEDV S genes were amplified, the sequences were analyzed with MEGA X and DNAStar, and a histopathological examination of typical PEDV-positive cases was performed. RT-PCR revealed positivity rates of 37.5% (66/176) for PEDV, 6.82% (12/176) for transmissible gastroenteritis virus, and 3.98% (7/176) for pig rotavirus. The test results for the years 2019, 2020, and 2021 were counted separately, PEDV positivity rates for the years were 34.88% (15/43), 39.33% (35/89), and 36.36% (16/44), respectively. Histopathological examination revealed atrophied, broken, and detached duodenal and jejunal intestinal villi, as typical of PED, and severe congestion of the intestinal submucosa. Moreover, the results of our study clearly indicate that the G2 subtype is prevalent as the dominant strain of PEDV in Shandong Province, where its rates of morbidity and mortality continue to be high. Based on a systematic investigation and analysis of PEDV's molecular epidemiology across Shandong Province, our results enrich current epidemiological data regarding PEDV and provide some scientific basis for preventing and controlling the disease.
Prevalence and phylogenetic analysis of human enteric emerging viruses in porcine stool samples in the Republic of Korea
Authors: Yeo Daseul , Hossain Md. Iqbal , Jung Soontag , Wang Zhaoqi , Seo Yeeun , Woo Seoyoung , Park Sunho , Seo Dong Joo , Rhee Min Suk , Choi Changsun
Published: September 2022

Emerging infectious diseases (EID) in humans and animals are proving to be a serious health concern. This study investigated the prevalence of emerging or re-emerging human enteric viruses in porcine stools and swabs. Eleven enteric EID viruses were selected as target viruses for the current study and ranked based on their impact on public health and food safety: enterovirus (EV), hepatitis E virus, norovirus GI and GII, sapovirus (SaV), adenovirus (AdV), astrovirus, rotavirus, hepatitis A virus, aichivirus, and bocavirus. Using real-time RT-PCR or real-time PCR, EID viruses were detected in 129 (86.0%) of 150 samples. The most prevalent virus was EV, which was detected in 68.0% of samples, followed by AdV with a detection rate of 38.0%. In following sequencing and phylogenetic analyses, 33.0% (58/176) of the detected viruses were associated with human enteric EID viruses, including AdV-41, coxsackievirus-A2, echovirus-24, and SaV. Our results show that porcine stools frequently contain human enteric viruses, and that few porcine enteric viruses are genetically related to human enteric viruses. These findings suggest that enteric re-emerging or EID viruses could be zoonoses, and that continuous monitoring and further studies are needed to ensure an integrated “One Health” approach that aims to balance and optimize the health of humans, animals, and ecosystems.
Enhanced Maximum Power Point Techniques for Solar Photovoltaic System under Uniform Insolation and Partial Shading Conditions: A Review
Authors: Bhukya Laxman , Kedika Narender Reddy , Salkuti Surender Reddy
Published: September 2022

In the recent past, the solar photovoltaic (PV) system has emerged as the most promising source of alternative energy. This solar PV system suffers from an unavoidable phenomenon due to the fluctuating environmental conditions. It has nonlinearity in I-V curves, which reduces the output efficiency. Hence, the optimum maximum power point (MPP) extraction of the PV system is difficult to achieve. Therefore, for maximizing the power output of PV systems, a maximum power point tracking (MPPT) mechanism, which is a control algorithm that can constantly track the MPP during operation, is required. However, choosing a suitable MPPT technique might be confusing because each method has its own set of advantages and disadvantages. Hence, a proper review of these methods is essential. In this paper, a state-of-the-art review on various MPPT techniques based on their classifications, such as offline, online, and hybrid techniques under uniform and nonuniform irradiances, is presented. In comparison to offline and online MPPT methods, intelligent MPPT techniques have better tracking accuracy and tracking efficiency with less steady state oscillations. Unlike online and offline techniques, intelligent methods track the global MPP under partial shade conditions. This review paper will be a useful resource for researchers, as well as practicing engineers, to pave the way for additional research and development in the MPPT field.
Effect of Fuel-Injection Distance and Cavity Rear-Wall Height on the Flameholding Characteristics in a Mach 2.52 Supersonic Flow
Authors: He Zhonghao , Wang Hongbo , Li Fan , Tian Yifu , Wan Minggang , Zhu Jiajian
Published: September 2022

The ethylene-fueled flameholding characteristics of a cavity-based scramjet combustor are experimentally and numerically investigated. The test facility used the air heater, which heats air from room temperature to total temperature 1477 K. A nozzle is installed behind the heater outlet to increase the air speed to Mach 2.52. Two cavity geometries with different rear-wall heights of 8 mm and 10 mm and two injection distances upstream of the cavities of 10 mm and 40 mm are compared to show the effect of these parameters. The CH* spontaneous emission images obtained by dual-camera synchronous shooting and the wall-pressure distribution obtained by a pressure-scan system are used to capture the flame dynamics. The global equivalence ratio range for different combination schemes is controlled from 0.14 to 0.27 in this paper. The results show that the conventional cavity (the rear-wall height is 10 mm) and the shorter injection distance can effectively decrease the lean blowoff limit of the combustor, while the rear-wall-expansion cavity (the rear-wall height is 8 mm) and the longer injection distance can effectively increase the rich blowoff limit. Compared with the injection distance, the rear-wall height of the cavity has little effect on the oscillation distribution of the shear layer-stabilized flame. However, the fuel-injection distance and cavity rear-wall height both have great influence on the spatial distribution of the flame.
A Comparative Study Using Fluorescent Confocal Microscopy and Flow Cytometry to Evaluate Chondrocyte Viability in Human Osteochondral Allografts
Authors: López-Chicón Patricia , Riba-Tietz Tatiana , Fariñas Oscar , Gelber Pablo-Eduardo , Casaroli-Marano Ricardo-Pedro , Vilarrodona Anna
Published: September 2022

The preservation conditions of fresh osteochondral allografts for clinical applications are critical due their objective: to transplant mature hyaline cartilage containing viable chondrocytes, maintaining their metabolic activity and also preserving the structural and functional characteristics of the extracellular matrix. The aim of the present study was to compare fluorescence confocal microscopy and flow cytometry techniques to evaluate the viability of the chondrocytes present in the osteochondral tissue, in order to determine their effectiveness and thus ensure reproducibility and robustness of the analysis. To this end, osteochondral allografts from human cadaveric donors were preserved at 4 °C for 3 weeks in a preservation medium supplemented with antibiotic and antifungal agents. Cell viability of chondrocytes was determined by monitoring the cartilage for 3 weeks of preservation by confocal fluorescence microscopy and flow cytometry, obtaining cell viabilities of 83.7 ± 2.6% and 55.8 ± 7.8% for week three, respectively. The confocal fluorescence microscopy approach is more advantageous and accurate, as it correlates better with actual cell viability values for monitoring osteochondral graft preservation, detecting only the cells that died a natural death associated with the preservation method.
Marangoni Patterns in a Non-Isothermal Liquid with Deformable Interface Covered by Insoluble Surfactant
Authors: Mikishev Alexander B. , Nepomnyashchy Alexander A.
Published: September 2022

Marangoni patterns are created by instabilities caused by thermocapillary and solutocapillary stresses on the deformable free surface of a thin liquid layer. In the present paper, we consider the influence of the insoluble surfactant on the selection and modulational instability of stationary Marangoni patterns near their onset threshold. The basic governing parameters of the problem are the Biot number characterizing the heat-transfer resistances of and at the surface, the Galileo number indicating the role of gravity via viscous forces, and the elasticity number specifying the influence of insoluble surfactant on the interfacial dynamics of the liquid. The paper includes a review of the previous results obtained in that problem as well as new ones.
The Use of Cryotherapy in Cosmetology and the Influence of Cryogenic Temperatures on Selected Skin Parameters—A Review of the Literature
Authors: Dzidek Adrianna , Piotrowska Anna
Published: September 2022

Cryotherapy is becoming an increasingly popular method used in medicine, physiotherapy, and cosmetology. It is used in the form of whole-body cryotherapy (WBC) and local cryotherapy. It is a tool for achieving analgesic and anti-inflammatory effects. Since the beginning of its use, its influence on the mental state has also been pointed out. The aim of this study was to analyze the available literature on the effect of cryogenic temperatures on the skin and the mechanisms induced by such a stimulus and its influence on well-being. A literature search of keywords or phrases was performed in PubMed®. Various effects of WBC on skin characteristics (hydration, pH, level of transepidermal water loss), mechanisms of anti-inflammatory effects, and effects on adipocytes were shown. Research on the impact of individual skin characteristics is not consistent. Positive effects on the reduction of inflammation and oxidative stress have been noted. Cryotherapy is also successfully used in dermatology to treat lentil spots, actinic keratosis, and ingrown toenails, remove viral warts, or relieve itching in atopic dermatitis. The results of the review also indicate the effectiveness of WBC as an adjunctive treatment for obesity. The number of papers available on the direct effects of WBC on the skin is still limited, despite the fact that it represents the first contact of the human body with cryogenic temperatures. Available data show that cold as a physical stimulus can be a safe and useful tool in cosmetology.
The Chronic Diseases Clinic of Ifakara (CDCI)—Establishing a Model Clinic for Chronic Care Delivery in Rural Sub-Saharan Africa
Authors: Weisser Maja , Rohacek Martin , Ndege Robert , Luoga Ezekiel , Katende Andrew , Mollel Getrud J. , Gingo Winfrid , Vanobberghen Fiona , Paris Daniel H. , Hatz Christoph , Battegay Manuel ,   on behalf of the KIULARCO Study Group
Published: September 2022

The rollout of antiretroviral drugs in sub-Saharan Africa to address the huge health impact of the HIV pandemic has been one of the largest projects undertaken in medical history and is an unprecedented medical success story. However, the path has been and still is characterized by many far reaching implementational challenges. Here, we report on the building and maintaining of a role model clinic in Ifakara, rural Southwestern Tanzania, within a collaborative project to support HIV services within the national program, training for staff and integrated research to better understand local needs and improve patients’ outcomes.
On Fourier-Based Inequality Indices
Authors: Toscani Giuseppe
Published: September 2022

Inequality indices are quantitative scores that take values in the unit interval, with a zero score denoting complete equality. They were originally created to measure the heterogeneity of wealth metrics. In this study, we focus on a new inequality index based on the Fourier transform that demonstrates a number of intriguing characteristics and shows great potential for applications. By extension, it is demonstrated that other inequality measures, such as the Gini and Pietra indices, can be usefully stated in terms of the Fourier transform, allowing us to illuminate characteristics in a novel and straightforward manner.
A Mixed-Integer Programming Approach for Unit Commitment in Micro-Grid with Incentive-Based Demand Response and Battery Energy Storage System
Authors: Nguyen-Duc Tuyen , Hoang-Tuan Linh , Ta-Xuan Hung , Do-Van Long , Takano Hirotaka
Published: September 2022

In the context of the increasing penetration of intermittent renewable energy resources (RES), one of the significant challenges facing traditional bulk power systems and microgrids is the scheduling generation units problem. Many studies have focused on solving the energy management problem for microgrids integrating RES. To address the intermittency caused by RES, flexible components such as battery energy storage systems (BESS) or demand response (DR) are considered. To clarify the problem of integrating these flexible components, a mixed-integer programming (MIP) approach for the unit commitment (UC) problem for microgrids with BESS and DR is proposed in this paper. An incentive-based demand response model as a negative power source and a detailed model for the vanadium redox battery (VRB) are introduced to improve the efficiency and reliability of microgrids. The objective optimization function, including the costs of generation, emissions, and maintenance, is minimized considering the uncertainty of the load and renewable energy sources. The obtained simulation results are compared with the genetic algorithm (GA) method as the basis for verification in different case studies. The obtained results have clarified the effect of using the BESS model and DR program on system operation.
Fractal Continuum Calculus of Functions on Euler-Bernoulli Beam
Authors: Samayoa Didier , Kryvko Andriy , Velázquez Gelasio , Mollinedo Helvio
Published: September 2022

A new approach for solving the fractal Euler-Bernoulli beam equation is proposed. The mapping of fractal problems in non-differentiable fractals into the corresponding problems for the fractal continuum applying the fractal continuum calculus (FdH3-CC) is carried out. The fractal Euler-Bernoulli beam equation is derived as a generalization using FdH3-CC under analogous assumptions as in the ordinary calculus and then it is solved analytically. To validate the spatial distribution of self-similar beam response, three different classical beams with several fractal parameters are analysed. Some mechanical implications are discussed.
Comparison of Treatment Outcomes among Sibling Oocytes Using Different Culture Systems—Conventional IVF versus INVOcell Device—And Evaluation of INVOcell User Satisfaction: The INVOcIVF Study
Authors: Yang Mohsin Wan Syahirah , Abdullah Chue Nor Shaireen , Abdul Hamid Fazilah , Abu Muhammad Azrai , Othman Sukhilmi , Mat Jin Norazilah , Woon Shu Yuan , Abdul Karim Abdul Kadir , Ahmad Mohd Faizal
Published: September 2022

INVOcell is considered an alternative to conventional IVF proposed for intravaginal embryo culture; however, implementation is still low because evidence is scanty regarding its outcome and, most importantly, the device’s user satisfaction. Thus, we aim to compare the embryo outcome of sibling oocytes following INVOcell culture with conventional IVF (cIVF) by assessing its clinical outcome (fertilization, blastulation rate, and good embryo quality) and the user satisfaction evaluation based on a local validation questionnaire. A prospective study was done at a university-setting hospital for 12 months (July 2021–2022). The oocytes collected were divided into INVOcell and cIVF groups equally. Inclusion criteria included <40 years old and body mass index (BMI) < 30 kg/m2. The pre- and post-satisfaction questionnaires were assessed. In total, 23 women were included following standard controlled ovarian stimulation (COS). The mean age was 32.9, and the mean BMI was 24.9 kg/m2. Most of them suffered from tubal factors. A total of 252 oocytes were collected and incubated accordingly (cIVF; 138, INVOcell; 114). The blastulation rate was superior in the INVOcell group (p = 0.16); otherwise, the fertilization rate and good embryo quality were not significantly different between both methods (p > 0.05). Overall, women were satisfied with the INVOcell device as they were adequately advised, follow-up was scheduled, and the lowest score was obtained for all side effects of the device. Although both methods produce similar fertilization rates and good-quality embryos, the blastulation rates were better in the INVOcell group. Functionally, it is a user-friendly device and tolerable. Therefore, INVOcell can be used as an alternative method for reproductive treatment in carefully selected patients without jeopardizing the IVF outcomes.
Modifiable Maternal Factors and Their Relationship to Postpartum Depression
Authors: Howard Kathryn , Maples Jill M. , Tinius Rachel A.
Published: September 2022

The purpose of the study was to examine how modifiable maternal factors (body mass index (BMI), household income, fatigue, sleep, breastfeeding status, diet, and physical activity) relate to postpartum depression (PPD) at 6 and 12 months postpartum. Participants (n = 26) participated in two study visits (6 and 12 months postpartum) where vitals, weight, body composition (skinfold anthropometrics), and physical activity levels (Actigraph GTX9 accelerometer) were assessed. Validated instruments (BRUMS-32, Subjective Exercise Experience Scale, Pittsburg Sleep Quality index, NIH breastfeeding survey, NIH Dietary History Questionnaire, and Edinburg Postnatal Depression Scale) assessed lifestyle and demographic factors of interest. PPD at six months was correlated to PPD at 12 months (r = 0.926, p < 0.001). At six months postpartum, PPD was positively correlated to BMI (r = 0.473, p = 0.020) and fatigue (r = 0.701, p < 0.001), and negatively correlated to household income (r = −0.442, p = 0.035). Mothers who were breastfeeding had lower PPD scores (breastfeeding 3.9 ± 3.5 vs. not breastfeeding 7.6 ± 4.8, p = 0.048). At 12 months, PPD was positively correlated to sleep scores (where a higher score indicates poorer sleep quality) (r = 0.752, p < 0.001) and fatigue (r = 0.680, p = 0.004). When analyzed collectively via regression analyses, household income and fatigue appeared to be the strongest predictors of PPD at six months postpartum.
Forecasting and Surveillance of COVID-19 Spread Using Google Trends: Literature Review
Authors: Saegner Tobias , Austys Donatas
Published: September 2022

The probability of future Coronavirus Disease (COVID)-19 waves remains high, thus COVID-19 surveillance and forecasting remains important. Online search engines harvest vast amounts of data from the general population in real time and make these data publicly accessible via such tools as Google Trends (GT). Therefore, the aim of this study was to review the literature about possible use of GT for COVID-19 surveillance and prediction of its outbreaks. We collected and reviewed articles about the possible use of GT for COVID-19 surveillance published in the first 2 years of the pandemic. We resulted in 54 publications that were used in this review. The majority of the studies (83.3%) included in this review showed positive results of the possible use of GT for forecasting COVID-19 outbreaks. Most of the studies were performed in English-speaking countries (61.1%). The most frequently used keyword was “coronavirus” (53.7%), followed by “COVID-19” (31.5%) and “COVID” (20.4%). Many authors have made analyses in multiple countries (46.3%) and obtained the same results for the majority of them, thus showing the robustness of the chosen methods. Various methods including long short-term memory (3.7%), random forest regression (3.7%), Adaboost algorithm (1.9%), autoregressive integrated moving average, neural network autoregression (1.9%), and vector error correction modeling (1.9%) were used for the analysis. It was seen that most of the publications with positive results (72.2%) were using data from the first wave of the COVID-19 pandemic. Later, the search volumes reduced even though the incidence peaked. In most countries, the use of GT data showed to be beneficial for forecasting and surveillance of COVID-19 spread.
Retrospective Assessment of Human–Chemical Interactions in Health-Disparity Populations: A Process Evaluation of Life History Calendars
Authors: Anastario Michael , Ceavers Olivia , Firemoon Paula , Xiuhtecutli Nezahualcoyotl , Rodriguez Ana Maria
Published: September 2022

Life-history calendars (LHCs) can produce retrospective data regarding numerous events, exposures, and sequences that have occurred across participants’ lifespans. In this mixed-quantitative-and-qualitative-methods study, processes of LHC administration were evaluated in two populations experiencing health disparities: foreign-born agricultural workers (n = 41) and Indigenous people who used injection drugs (IPWIDS) (n = 40). LHC administrator and participant perspectives were elicited during follow-up survey activities. In both agricultural workers and IPWIDs, over half of participants reported that the LHC made it easier to remember things about the past, and participant age was associated with cumulative experience in different domains of interest. Qualitative findings suggested that data-collector training and the development of concise interview guides are critical for improving LHC data quality. Participants described ethical themes, including utilitarian, cathartic, and reflective aspects, of LHC participation. Future iterations of the LHC may benefit from providing free-form and open-ended spaces for participants to reflect on the LHC activity following LHC administration.
Gaseous Air Pollutants and Respirable Crystalline Silica Inside and Outside Homes at Brick Kilns in Bhaktapur, Kathmandu Valley, Nepal
Authors: Beard John D. , Thygerson Steven M. , Olivares Alisandra , Tadje Jaxson E. , Willis Selah , Johnston James D.
Published: September 2022

Household and ambient air pollution remain public health problems in much of the world. Brick kiln employees in Nepal may be particularly at risk of high air pollution exposures and resulting health effects due to high levels of outdoor air pollution, substandard housing, and indoor biomass cooking. We conducted a cross-sectional study of indoor and outdoor air pollution concentrations at workers’ homes at four fixed chimney Bull’s trench brick kilns in Bhaktapur, Kathmandu Valley, Nepal. We measured air concentrations of carbon monoxide (CO), carbon dioxide (CO2), nitrogen dioxide (NO2), sulfur dioxide (SO2), and respirable crystalline silica (SiO2; cristobalite, quartz, tridymite) using established methods and conducted a survey about characteristics of homes or samples that may be associated with air pollution concentrations. Geometric mean concentrations of CO, CO2, and SiO2 (quartz) were 0.84 ppm, 1447.34 ppm, and 6.22 µg/m3, respectively, whereas concentrations of all other air pollutants measured below lower detection limits. Most characteristics of homes or samples were not associated with air pollution concentrations. We found a positive association between the variable how long lived in house and SiO2 (quartz) concentrations, which may reflect sustained take-home exposure to SiO2 (quartz) over time. Interventions should focus on administrative controls to reduce take-home exposure to SiO2 (quartz) in this population.
A Study on the Non-Linear Impact of Digital Technology Innovation on Carbon Emissions in the Transportation Industry
Authors: Chen Xiaoqin , Mao Shenya , Lv Siqi , Fang Zhong
Published: September 2022

Transportation is an important part of social and economic development and is also a typical high-energy and high-emissions industry. Achieving low-carbon development in the transportation industry is a much-needed requirement and the only way to achieve high-quality development. Therefore, based on the relevant data of 30 provinces in China from 2010 to 2018, this research uses the static panel model, panel threshold model and spatial Durbin model to conduct an empirical study on the impact and mechanism of digital innovation on carbon emissions in the transportation industry, and draws the following conclusions. (1) Carbon emissions in the transportation industry have dynamic and continuous adjustment characteristics. (2) There is a significant inverted U-shape non-linear relationship between the level of digital innovation and carbon emissions in the industry. In regions with a low level of digital innovation, the application of digital technology increases carbon emissions in this industry, but as the level of digital innovation continues to increase its application suppresses carbon emissions, showing an effect of carbon emission reduction. (3) The impact of digital innovation on carbon emissions in the transportation industry has a spatial spillover effect, and its level in one province significantly impacts carbon emissions in other provinces’ transportation industry through the spatial spillover effect. Therefore, it is recommended to further strengthen the exchange and cooperation of digital innovation in the transportation industry between regions, improve the scale of digitalization in this industry, and accelerate its green transformation through digital innovation, thus promoting the green, low-carbon, and sustainable development of China’s economy.
Effect of a Short-Term Intervention with Lactobacillus salivarius Probiotic on Early Childhood Caries—An Open Label Randomized Controlled Trial
Authors: Staszczyk Małgorzata , Jamka-Kasprzyk Małgorzata , Kościelniak Dorota , Cienkosz-Stepańczak Beata , Krzyściak Wirginia , Jurczak Anna
Published: September 2022

ECC is a significant therapeutic and social problem and a global burden on public health. The aim of this clinical trial was to test whether a 2-week daily consumption of chewing tablets containing thermally inactivated L. salivarius reduces the 12-month caries increment compared to the control group. The investigation was a single-center, randomized, controlled open-label, blinded end-point evaluation trial in two parallel groups. At baseline, 140 generally healthy children between 3 and 6 years of age with or without ECC were randomly assigned to the probiotic test group (n = 70) or to the treatment as the usual control group (n = 70). The primary outcome measure was the 1-year increment in caries incidence and prevalence. Secondary endpoints assessed were the initial, cavitated and obvious dentinal caries increment as well as the measurement of dental plaque accumulation, as an indicator of the ECC risk. Data were collected through the clinical assessment of the children’s caries (dmft and ICDAS II) and oral hygiene status (DI-S of OHI-S index). Caries incidence and prevalence were statistically significantly lower in the probiotic group versus the control group (p < 0.001 and p = 0.0075). The initial and final mean OHI-S scores in the probiotic group did not show any significant differences. In conclusion, the regular short-term intake of probiotics may reduce caries development. Our findings suggest that self-administered probiotic therapy may provide a good complement to increase the effectiveness of individual preventive home care in preschool children. This is the first clinical study evaluating the effect of a short-term probiotic intervention on reducing early childhood caries with 12 months of follow-up.
Older People’s Long-Term Care Preferences in China: The Impact of Living with Grandchildren on Older People’s Willingness and Family Decisions
Authors: Deng Tongbo , Fan Yafan , Wu Mengdi , Li Min
Published: September 2022

The purpose of this paper was to better understand the long-term care preferences of older people based on intergenerational demonstration effects and social exchange theory, derived from the literature on intergenerational family relationships. The authors relied on the 2014 China Longitudinal Ageing Social Survey database to test the study hypotheses. The results indicated that living with grandchildren was negatively related to the institutional care preferences of older people. Family members’ attitudes and older people’s life satisfaction significantly mediated the relationship between living with grandchildren and their institutional care preferences. Gender and marital status had potentially diverse effects on institutional care preferences. Therefore, in the context of China’s culture of filial piety, social exchange, and intergenerational demonstration, motivation may help foster intergenerational exchange and reciprocity in eldercare arrangements.
Autogenous Healing in 10-Years Aged Cementitious Composites Using Microfibers and Superabsorbent Polymers
Authors: Snoeck Didier
Published: September 2022

Cement-based materials are the most widely used construction materials in the world for infrastructure works. Unfortunately, they come with a high environmental burden due to carbon dioxide emissions and the need for regular maintenance and repairs. Without these, the service life can decrease. By using a self-healing approach, the service life can be extended, as well as the durability and sustainability of the building material. As the ability to self-heal depends on the age of the material, so will the potential influence of added materials to promote this healing. However, the effects of reduced healing beyond one year are not ubiquitous in the literature. In this study, specimens were studied after a decade of maturation under different storage conditions to conclude on the self-healing capabilities of the old samples. Cracks can still be partially healed after ten years, mainly due to the formation of calcium carbonate crystals, related to the observed regain in mechanical properties measured by repeated four-point bending tests. The initial addition of superabsorbent polymers to the mixture results in greater healing compared to the reference samples, making it a sustainable option for the future of cement-based composites.