bluuebunny/crossref_metadata_2025 huggingface dataset:
Corrosion Mechanism of L360 Pipeline Steel Coated with S8 in CO2-Cl− System at Different pH Values
Authors: Wang Fan , Li Jinling , Qu Chengtun , Yu Tao , Li Yan , Zhu Shidong , Yang Bo , Cheng Frank
Published: December 2021

The corrosion behavior of L360 pipeline steel coated with or without elemental sulfur (S8) in CO2–Cl− medium at different pH was studied. An autoclave was used to simulate the working conditions for forming the corrosion scale, and an electrochemical workstation with a three-electrode cell was used to analyze the electrochemical characterization of the corrosion scale. A wire beam electrode was used to determine the potential and current distribution, and scanning electron microscopy and X-ray diffraction were used to characterize the morphology and composition of the corrosion scale. The results showed that the deposition of S8 on the surface of the electrodes caused serious localized corrosion, especially under acidic conditions. The morphology and localized corrosion intensity index further proved that the deposition of S8 significantly promoted corrosion, especially pitting corrosion. Finally, a novel corrosion mechanism of L360 pipeline steel coated with S8 in a CO2-Cl− environment under acidic conditions was proposed, and we then modeled the theoretical mechanisms that explained the experimental results.
Corner Strengthening by Local Thickening and Ausforming Using Planar Compression in Hot Stamping of Ultra-High Strength Steel Parts
Authors: Maeno Tomoyoshi , Mori Ken-ichiro , Homma Hiroki , Talebi-Anaraki Ali , Ikeda Ryohei
Published: December 2021

Hot-stamped products are widely used for the body-in-white of an automobile as they are lightweight and improve crashworthiness. A hot-stamping process using planar compression was developed to strengthen corners of ultra-high strength parts by local thickening and hardening. In this process, the corners are thickened by compressing the blank in the planar direction with the upper and lower dies while blocking the movement of both edges with stoppers in the latter stage of forming. Thickening of the corners largely heightens the strength of the formed parts. Not only the thickness but also the hardness of the corner was increased by large plastic deformation and die quenching. For a hot hat-shaped part, a 30% increase in thickness and a 530 HV20 hardness around the corners were attained. The bending rigidity and strength of the formed parts thickened by 30% in the corners increased by 25% and 20%, respectively. In addition, the improvements of the part shape accuracy and the sidewall quenchability were obtained.
Challenges and Prospects of Steelmaking towards the Year 2050
Authors: Holappa Lauri
Published: December 2021

The world is experiencing a period of imminent threat owing to climate change [...]
Targeted Metabolomics Analysis of Bile Acids in Patients with Idiosyncratic Drug-Induced Liver Injury
Authors: Xie Zhongyang , Zhang Lingjian , Chen Ermei , Lu Juan , Xiao Lanlan , Liu Qiuhong , Zhu Danhua , Zhang Fen , Xu Xiaowei , Li Lanjuan
Published: December 2021

Drug-induced liver injury (DILI) is rare but clinically important due to a high rate of mortality. However, specific biomarkers for diagnosing and predicting the severity and prognosis of DILI are lacking. Here, we used targeted metabolomics to identify and quantify specific types of bile acids that can predict the severity of DILI. A total of 161 DILI patients were enrolled in this prospective cohort study, as well as 31 health controls. A targeted metabolomics method was used to identify 24 types of bile acids. DILI patients were divided into mild, moderate, and severe groups according to disease severity. A multivariate analysis was performed to identify characteristic bile acids. Then the patients were divided into severe and non-severe groups, and logistic regression was used to identify bile acids that could predict DILI severity. Among the enrolled DILI patients, 32 were in the mild group, 90 were in the moderate group, and 39 were in the severe group. Orthogonal partial least squares-discriminant analysis (OPLS-DA) modeling clearly discriminated among the different groups. Among the four groups, glycochenodeoxycholate (GCDCA), taurochenodeoxycholate (TCDCA), deoxycholic acid (DCA), Nor Cholic acid (NorCA), glycocholic acid (GCA), and taurocholic acid (TCA) showed significant differences in concentration between at least two groups. NorCA, GCDCA, and TCDCA were all independent risk factors that differentiated severe DILI patients from the other groups. The area under the receiver operating characteristic curve (AUROC) of GCDCA, TCDCA, and NorCA was 0.856, 0.792, and 0.753, respectively. Together, these three bile acids had an AUROC of 0.895 for predicting severe DILI patients. DILI patients with different disease severities have specific bile acid metabolomics. NorCA, GCDTA, and TCDCA were independent risk factors for differentiating severe DILI patients from less-severe patients and have the potential to predict DILI severity.
A Hydrogel-Based Microfluidic Nerve Cuff for Neuromodulation of Peripheral Nerves
Authors: Thakur Raviraj , Aplin Felix P. , Fridman Gene Y.
Published: December 2021

Implantable neuromodulation devices typically have metal in contact with soft, ion-conducting nerves. These neural interfaces excite neurons using short-duration electrical pulses. While this approach has been extremely successful for multiple clinical applications, it is limited in delivering long-duration pulses or direct current (DC), even for acute term studies. When the charge injection capacity of electrodes is exceeded, irreversible electrochemical processes occur, and toxic byproducts are discharged directly onto the nerve, causing biological damage. Hydrogel coatings on electrodes improve the overall charge injection limit and provide a mechanically pliable interface. To further extend this idea, we developed a silicone-based nerve cuff lead with a hydrogel microfluidic conduit. It serves as a thin, soft and flexible interconnection and provides a greater spatial separation between metal electrodes and the target nerve. In an in vivo rat model, we used this cuff to stimulate and record from sciatic nerves, with performance comparable to that of metal electrodes. Further, we delivered DC through the lead in an acute manner to induce nerve block that is reversible. In contrast to most metallic cuff electrodes, which need microfabrication equipment, we built this cuff using a consumer-grade digital cutter and a simplified molding process. Overall, the device will be beneficial to neuromodulation researchers as a general-purpose nerve cuff electrode for peripheral neuromodulation experiments.
Modular 3D In Vitro Artery-Mimicking Multichannel System for Recapitulating Vascular Stenosis and Inflammation
Authors: Cho Minkyung , Park Je-Kyun
Published: December 2021

Inflammation and the immune response in atherosclerosis are complex processes involving local hemodynamics, the interaction of dysfunctional cells, and various pathological environments. Here, a modular multichannel system that mimics the human artery to demonstrate stenosis and inflammation and to study physical and chemical effects on biomimetic artery models is presented. Smooth muscle cells and endothelial cells were cocultured in the wrinkled surface in vivo-like circular channels to recapitulate the artery. An artery-mimicking multichannel module comprised four channels for the fabrication of coculture models and assigned various conditions for analysis to each model simultaneously. The manipulation became reproducible and stable through modularization, and each module could be replaced according to analytical purposes. A chamber module for culture was replaced with a microfluidic concentration gradient generator (CGG) module to achieve the cellular state of inflamed lesions by providing tumor necrosis factor (TNF)-α, in addition to the stenosis structure by tuning the channel geometry. Different TNF-α doses were administered in each channel by the CGG module to create functional inflammation models under various conditions. Through the tunable channel geometry and the microfluidic interfacing, this system has the potential to be used for further comprehensive research on vascular diseases such as atherosclerosis and thrombosis.
Preliminary Economic Feasibility Study of Ferromanganese Nodule Mining by Mechanical Lifting and Small-Scale Collectors
Authors: Hong Sup , Kim Hyung-Woo , Yeu Tae-Kyung , Arai Rei , Yamazaki Tetsuo
Published: December 2021

Ferromanganese nodules have been recognized as a potential future metal source for over 50 years. Many research and development efforts have been conducted by many organizations. Most of the efforts have been concentrated into the mining technologies especially for hydraulic lifting through riser pipes with bulk-scale nodule collector. However, no commercial mining venture exists. Uncertainty in the economy of nodule mining is considered to be the reason for this. In order to improve the economy, a mining subsystem based on mechanical lifting and small-scale collectors is proposed and the preliminary economic feasibility is examined in this study. The benefit was at a favorable level compared with that using hydraulic lifting with bulk-scale collector. From the viewpoint of environmental impact assessment, environmental considerations of deep-sea sediment plume are explained.
Bactericidal Activity of Multilayered Hybrid Structures Comprising Titania Nanoparticles and CdSe Quantum Dots under Visible Light
Authors: Kolesova Ekaterina , Bulgakova Anastasia , Maslov Vladimir , Veniaminov Andrei , Dubavik Aliaksei , Gun’ko Yurii , Efremenkova Olga , Oleinikov Vladimir , Orlova Anna
Published: December 2021

Titania nanoparticle/CdSe quantum dot hybrid structures are a promising bactericidal coating that exhibits a pronounced effect against light-sensitive bacteria. Here, we report the results of a comprehensive study of the photophysical properties and bactericidal functionality of these hybrid structures on various bacterial strains. We found that our structures provide the efficient generation of superoxide anions under the action of visible light due to electron transfer from QDs to titania nanoparticles with ~60% efficiency. We also tested the antibacterial activity of hybrid structures on five strains of bacteria. The formed structures combined with visible light irradiation effectively inhibit the growth of Escherichia coli, Bacillus subtilis, and Mycobacterium smegmatis bacteria, the last of which is a photosensitive causative agent model of tuberculosis.
Multi-Strain Probiotic Supplementation with a Product Containing Human-Native S. salivarius K12 in Healthy Adults Increases Oral S. salivarius
Authors: Cernioglo Karina , Kalanetra Karen M. , Meier Anna , Lewis Zachery T. , Underwood Mark A. , Mills David A. , Smilowitz Jennifer T.
Published: December 2021

Streptococcus salivarius (S. salivarius) K12 supplementation has been found to reduce the risk of recurrent upper respiratory tract infections. Yet, studies have not reported the effect of supplementation on oral S. salivarius K12 levels or the salivary microbiome. This clinical trial was designed to determine how supplementation with S. salivarius K12 influences the oral microbiome. In a randomized, double-blind, placebo-controlled trial, 13 healthy adults received a probiotic powder (PRO) containing Lactobacillus acidophilus, Bifidobacterium lactis, and S. salivarius K12 and 12 healthy adults received a placebo-control powder (CON) (n = 12) for 14 consecutive days. Oral S. salivarius K12 and total bacteria were quantified by qPCR and the overall oral microbiome was measured using 16S rRNA amplicon sequencing. Supplementation significantly increased mean salivary S. salivarius K12 levels by 5 logs compared to baseline for the PRO group (p < 0.0005), which returned to baseline 2 weeks post-supplementation. Compared with the CON group, salivary S. salivarius K12 was 5 logs higher in the PRO group at the end of the supplementation period (p < 0.001). Neither time nor supplementation influenced the overall oral microbiome. Supplementation with a probiotic cocktail containing S. salivarius K12 for two weeks significantly increased levels of salivary S. salivarius K12.
Immunological and Genetic Investigation of SARS-CoV-2 Reinfection in an Otherwise Healthy, Young Marine Recruit
Authors: Letizia Andrew G. , Arnold Catherine E. , Adhikari Bishwo N. , Voegtly Logan J. , Glang Lindsay , Rice Gregory K. , Goforth Carl W. , Schilling Megan A. , Weir Dawn L. , Malagon Francisco , Ramos Irene , Vangeti Sindhu , Gonzalez-Reiche Ana S. , Cer Regina Z. , Sealfon Stuart C. , van Bakel Harm , Bishop-Lilly Kimberly A.
Published: December 2021

We used epidemiologic and viral genetic information to identify a case of likely reinfection in an otherwise healthy, young Marine recruit enrolled in the prospective, longitudinal COVID-19 Health Action Response for Marines (CHARM) study, and we paired these findings with serological studies. This participant had a positive RT-PCR to SARS-CoV-2 upon routine sampling on study day 7, although he was asymptomatic at that time. He cleared the infection within seven days. On study day 46, he had developed symptoms consistent with COVID-19 and tested positive by RT-PCR for SARS-CoV-2 again. Viral whole genome sequencing was conducted from nares swabs at multiple time points. The day 7 sample was determined to be lineage B.1.340, whereas both the day 46 and day 49 samples were B.1.1. The first positive result for anti-SARS-CoV-2 IgM serology was collected on day 49 and for IgG on day 91. This case appears most consistent with a reinfection event. Our investigation into this case is unique in that we compared sequence data from more than just paired specimens, and we also assayed for immune response after both the initial infection and the later reinfection. These data demonstrate that individuals who have experienced an infection with SARS-CoV-2 may fail to generate effective or long-lasting immunity, similar to endemic human beta coronaviruses.
Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light
Authors: Terrosi Chiara , Anichini Gabriele , Docquier Jean Denis , Gori Savellini Gianni , Gandolfo Claudia , Pavone Francesco Saverio , Cusi Maria Grazia
Published: December 2021

Blue LED light has proven to have a powerful bacteria-killing ability; however, little is known about its mechanism of virucidal activity. Therefore, we analyzed the effect of blue light on different respiratory viruses, such as adenovirus, respiratory syncytial virus and SARS-CoV-2. The exposure of samples to a blue LED light with a wavelength of 420 nm (i.e., in the visible range) at 20 mW/cm2 of irradiance for 15 min appeared optimal and resulted in the complete inactivation of the viral load. These results were similar for all the three viruses, demonstrating that both enveloped and naked viruses could be efficiently inactivated with blue LED light, regardless of the presence of envelope and of the viral genome nature (DNA or RNA). Moreover, we provided some explanations to the mechanisms by which the blue LED light could exert its antiviral activity. The development of such safe and low-cost light-based devices appears to be of fundamental utility for limiting viral spread and for sanitizing small environments, objects and surfaces, especially in the pandemic era.
The Impact of Tuberculosis on the Well-Being of Adolescents and Young Adults
Authors: Moscibrodzki Patricia , Enane Leslie A. , Hoddinott Graeme , Brooks Meredith B. , Byron Virginia , Furin Jennifer , Seddon James A. , Meyersohn Lily , Chiang Silvia S.
Published: December 2021

The health needs of adolescents and young adults (AYAs) have been neglected in tuberculosis (TB) care, control, and research. AYAs, who are distinct from younger children and older adults, undergo dynamic physical, psychological, emotional, cognitive, and social development. Five domains of adolescent well-being are crucial to a successful transition between childhood and adulthood: (1) Good health; (2) connectedness and contribution to society; (3) safety and a supportive environment; (4) learning, competence, education, skills, and employability; and (5) agency and resilience. This review summarizes the evidence of the impact of TB disease and treatment on these five domains of AYA well-being.
Detection of Babesia spp. in High Altitude Cattle in Ecuador, Possible Evidence of the Adaptation of Vectors and Diseases to New Climatic Conditions
Authors: Chávez-Larrea María A. , Cholota-Iza Cristina , Medina-Naranjo Viviana , Yugcha-Díaz Michelle , Ron-Román Jorge , Martin-Solano Sarah , Gómez-Mendoza Gelacio , Saegerman Claude , Reyna-Bello Armando
Published: December 2021

Background: Babesia species are intraerythrocytic protozoa, distributed in tropical and subtropical areas of the world, causing anemic diseases in many animals, including cattle. This disease, called babesisosis, is transmitted from one animal to another through ticks (Tick Borne-Disease or TBD). On the other hand, Ecuador has a tropical climate that allows the development of the vector Rhipicephalus microplus, and therefore favors the transmission of Babesia spp. in cattle. Methods and principal findings: We determined the presence of Babesia spp. by PCR using 18s ribosomal gene as target (18s PCR) in 20 farms in the area of El Carmen (zone below 300 m above sea level) and 1 farm in Quito (2469 m.a.s.l.). In addition, we analyzed parameters such as age, sex, and packed cell volume (PCV) as explanatory variable associated with the disease. Results: The 18s PCR test showed that 18.94% (14.77% Babesia bovis and 4.17% Babesia bigemina) and 20.28% (14.69% B. bovis and 5.59% B. bigemina) of the cattle were positive for Babesia spp in farms sampled in El Carmen and in Quito, respectively. Age influenced the presence of animals positive for Babesia spp., but sex and PCV did not. The phylogenetic analysis of sequences showed 4 isolates of B. bovis and 3 isolates of B. bigemina in the 2 study zones, with similarities between 99.73 and 100% with other sequences. One B. bovis isolate was similar in the zone of El Carmen and Quito. Conclusion and significance: This work is the first molecular characterization of B. bigemina and B. bovis in Ecuador, and it is also the first evidence of Babesia spp. in cattle in the area of Quito at an altitude of 2469 m.a.s.l., being the highest altitude reported for animals with babesiosis and for the tick R. microplus. Climatic factors as well as mobility of tick-carrying animals without any control allow the presence of Babesiosis outbreaks in new geographical areas.
CRF-R1 Antagonist Treatment Exacerbates Circadian Corticosterone Secretion under Chronic Stress, but Preserves HPA Feedback Sensitivity
Authors: Ibarguen-Vargas Yadira , Leman Samuel , Palme Rupert , Belzung Catherine , Surget Alexandre
Published: December 2021

Despite promising initial reports, corticotropin-releasing factor receptor type-1 (CRF-R1) antagonists have mostly failed to display efficacy in clinical trials for anxiety or depression. Rather than broad-spectrum antidepressant/anxiolytic-like drugs, they may represent an ‘antistress’ solution for single stressful situations or for patients with chronic stress conditions. However, the impact of prolonged CRF-R1 antagonist treatments on the hypothalamic–pituitary–adrenal (HPA) axis under chronic stress conditions remained to be characterized. Hence, our study investigated whether a chronic CRF-R1 antagonist (crinecerfont, formerly known as SSR125543, 20 mg·kg−1·day−1 ip, 5 weeks) would alter HPA axis basal circadian activity and negative feedback sensitivity in mice exposed to either control or chronic stress conditions (unpredictable chronic mild stress, UCMS, 7 weeks), through measures of fecal corticosterone metabolites, plasma corticosterone, and dexamethasone suppression test. Despite preserving HPA axis parameters in control non-stressed mice, the 5-week crinercerfont treatment improved the negative feedback sensitivity in chronically stressed mice, but paradoxically exacerbated their basal corticosterone secretion nearly all along the circadian cycle. The capacity of chronic CRF-R1 antagonists to improve the HPA negative feedback in UCMS argues in favor of a potential therapeutic benefit against stress-related conditions. However, the treatment-related overactivation of HPA circadian activity in UCMS raise questions about possible physiological outcomes with long-standing treatments under ongoing chronic stress.
Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review
Authors: Md Shadab , Alhakamy Nabil A. , Karim Shahid , Gabr Gamal A , Iqubal Mohammad Kashif , Murshid Samar S. A.
Published: December 2021

Lung cancer is one of the most commonly diagnosed cancers and is responsible for a large number of deaths worldwide. The pathogenic mechanism of lung cancer is complex and multifactorial in origin. Thus, various signaling pathways as targets for therapy are being examined, and many new drugs are in the pipeline. However, both conventional and target-based drugs have been reported to present significant adverse effects, and both types of drugs can affect the clinical outcome in addition to patient quality of life. Recently, miRNA has been identified as a promising target for lung cancer treatment. Therefore, miRNA mimics, oncomiRs, or miRNA suppressors have been developed and studied for possible anticancer effects. However, these miRNAs also suffer from the limitations of low stability, biodegradation, thermal instability, and other issues. Thus, nanocarrier-based drug delivery for the chemotherapeutic drug delivery in addition to miRNA-based systems have been developed so that existing limitations can be resolved, and enhanced therapeutic outcomes can be achieved. Thus, this review discusses lung cancer’s molecular mechanism, currently approved drugs, and their adverse effects. We also discuss miRNA biosynthesis and pathogenetic role, highlight pre-clinical and clinical evidence for use of miRNA in cancer therapy, and discussed limitations of this therapy. Furthermore, nanocarrier-based drug delivery systems to deliver chemotherapeutic drugs and miRNAs are described in detail. In brief, the present review describes the mechanism and up-to-date possible therapeutic approaches for lung cancer treatment and emphasizes future prospects to bring these novel approaches from bench to bedside.
New Aspects of Secretory Structures in Five Alismataceae Species: Laticifers or Ducts?
Authors: Leme Flávia Maria , Bento João Pedro Silvério Pena , Fabiano Vitoria Silva , González Jean David Varilla , Pott Vali Joana , Arruda Rosani do Carmo de Oliveira
Published: December 2021

The secretory structures of Alismataceae have been described as secretory ducts, laticifer ducts, laticifer canals or schizogenous ducts. However, these terms are not found in the specialized literature, and ontogenetic analyses for the exact classification of these structures are missing. Accordingly, more studies regarding the secretory structures of Alismataceae are necessary to establish homology in the family or in the order. Thus, the aim of this study was to describe the anatomy, ontogeny, distribution in the organs and exudate composition of the secretory structures present in five Alismataceae species in order to determine whether the family has laticifers or secretory ducts. Samples of leaves, flowers and floral apices were processed for anatomical and histochemical analyses by light microscopy. The analysis indicated the presence of anastomosing secretory ducts in all species, occurring in both leaves and flowers. The exudate contains lipids, alkaloids, proteins and polysaccharides, including mucilage. The secretory duct structure, distribution and exudate composition suggest a defense role against herbivory and in wound sealing. The presence of secretory ducts in all species analyzed indicates a probable synapomorphy for the family.
Polymerization and Structure of Opposing Polymer Brushes Studied by Computer Simulations
Authors: Halagan Krzysztof , Banaszak Michal , Jung Jaroslaw , Polanowski Piotr , Sikorski Andrzej
Published: December 2021

A model of the polymerization process during the formation of a pair of polymer brushes was designed and investigated. The obtained system consisted of two impenetrable parallel surfaces with the same number of chains grafted on both surfaces. Coarse-grained chains embedded in nodes of a face-centered cubic lattice with excluded volume interactions were obtained by a ‘grafted from’ procedure. The structure of synthesized macromolecular systems was also studied. Monte Carlo simulations using the dynamic lattice liquid model were employed using dedicated parallel machine ARUZ in a large size and time scale. The parameters of the polymerization process were found to be crucial for the proper structure of the brush. It was found that for high grafting densities, chains were increasingly compressed, and there is surprisingly little interpenetration of chains from opposite surfaces. It was predicted and confirmed that in a polydisperse sample, the longer chains have unique configurations consisting of a stretched stem and a coiled crown.
An Overview of Recent Advancements in Microbial Polyhydroxyalkanoates (PHA) Production from Dark Fermentation Acidogenic Effluents: A Path to an Integrated Bio-Refinery
Authors: Saratale Rijuta Ganesh , Cho Si-Kyung , Saratale Ganesh Dattatraya , Kumar Manu , Bharagava Ram Naresh , Varjani Sunita , Kadam Avinash A. , Ghodake Gajanan S. , Palem Ramasubba Reddy , Mulla Sikandar I. , Kim Dong-Su , Shin Han-Seung
Published: December 2021

Global energy consumption has been increasing in tandem with economic growth motivating researchers to focus on renewable energy sources. Dark fermentative hydrogen synthesis utilizing various biomass resources is a promising, less costly, and less energy-intensive bioprocess relative to other biohydrogen production routes. The generated acidogenic dark fermentative effluent [e.g., volatile fatty acids (VFAs)] has potential as a reliable and sustainable carbon substrate for polyhydroxyalkanoate (PHA) synthesis. PHA, an important alternative to petrochemical based polymers has attracted interest recently, owing to its biodegradability and biocompatibility. This review illustrates methods for the conversion of acidogenic effluents (VFAs), such as acetate, butyrate, propionate, lactate, valerate, and mixtures of VFAs, into the value-added compound PHA. In addition, the review provides a comprehensive update on research progress of VFAs to PHA conversion and related enhancement techniques including optimization of operational parameters, fermentation strategies, and genetic engineering approaches. Finally, potential bottlenecks and future directions for the conversion of VFAs to PHA are outlined. This review offers insights to researchers on an integrated biorefinery route for sustainable and cost-effective bioplastics production.
Optimization of Microwave-Assisted Extraction of Polyphenols from Lemon Myrtle: Comparison of Modern and Conventional Extraction Techniques Based on Bioactivity and Total Polyphenols in Dry Extracts
Authors: Saifullah Md , McCullum Rebecca , Vuong Quan Van
Published: December 2021

The aromatic herb lemon myrtle is a good source of polyphenols, with high antioxidant and antimicrobial capacity. In this study, the green extraction technique microwave-assisted extraction (MAE) was applied and the extraction parameters were optimized using response surface methodology (RSM) to maximize the extraction yield of phenolic compound and antioxidant properties. Then, it was compared with other popular novel and conventional extraction techniques including ultrasound-assisted extraction (UAE) and shaking water bath (SWB) to identify the most effective technique for extraction of phenolic compounds from lemon myrtle. The results showed that the MAE parameters including radiation time, power, and sample to solvent ratio had a significant influence on the extraction yield of phenolic compounds and antioxidant capacity. The optimal MAE conditions were radiation time of 6 min, microwave power of 630 W, and sample to solvent ratio of 6 g/100 mL. Under optimal conditions, MAE dry extract had similar levels of total phenolic compounds (406.67 ± 8.57 mg GAE/g DW), flavonoids (384.57 ± 2.74 mg CE/g DW), proanthocyanidins (336.54 ± 7.09 mg CE/g DW), antioxidant properties, and antibacterial properties against (Staphylococcus lugdunensis and Bacillus cereus) with the other two methods. However, MAE is eight-times quicker and requires six-times less solvent volume as compared to UAE and SWB. Therefore, MAE is recommended for the extraction of polyphenols from lemon myrtle leaf.
Protecting Buddhist Women from Muslim Men: “Love Jihad” and the Rise of Islamophobia in Myanmar
Authors: Frydenlund Iselin
Published: December 2021

Buddhist protectionism in contemporary Myanmar revolves around fears of the decline of Buddhism and deracination of the amyo (group/“race”). Buddhist protectionists and Burmese nationalists have declared Islam and Muslims the greatest threat to race and religion, and Myanmar has witnessed widespread distribution of anti-Islamic and anti-Muslim content, as well as massive violence against Muslim minority communities, the Rohingya in particular. The Indian neologism “Love Jihad” has scarce reference in contemporary Burmese Buddhist discourses, but, importantly, the tropes of aggressive male Muslim sexuality and (forced) conversion through marriage (“love jihad”) have been one of the core issues in Buddhist protectionism in Myanmar. The article shows that such tropes of the threatening foreign male have strong historical legacies in Myanmar, going back to colonial Burma when Burmese concerns over Indian male immigrant workers resulted in both anti-Indian violence and anti-miscegenation laws. Importantly, however, compared to colonial Indophobia and military era xenophobic nationalism, contemporary constructions are informed by new political realities and global forces, which have changed Buddhist protectionist imaginaries of gender and sexuality in important ways. Building on Sara R. Farris’ concept of “femonationalism”, and Rogers Brubaker’s concept of civilizationism, the article shows how Global Islamophobia, as well as global discourses on women’s rights and religious freedom, have informed Buddhist protectionism beyond ethnonationalism in the traditional sense.
Threshold Definition for Monitoring Gapa Landslide under Large Variations in Reservoir Level Using GNSS
Authors: Wu Shuangshuang , Hu Xinli , Zheng Wenbo , Berti Matteo , Qiao Zhitian , Shen Wei
Published: December 2021

The triggering threshold is one of the most important parameters for landslide early warning systems (EWSs) at the slope scale. In the present work, a velocity threshold is recommended for an early warning system of the Gapa landslide in Southwest China, which was reactivated by the impoundment of a large reservoir behind Jinping’s first dam. Based on GNSS monitoring data over the last five years, the velocity threshold is defined by a novel method, which is implemented by the forward and reverse double moving average of time series. As the landslide deformation is strongly related to the fluctuations in reservoir water levels, a crucial water level is also defined to reduce false warnings from the velocity threshold alone. In recognition of the importance of geological evolution, the evolution process of the Gapa landslide from topping to sliding is described in this study to help to understand its behavior and predict its potential trends. Moreover, based on the improved Saito’s three-stage deformation model, the warning level is set as “attention level”, because the current deformation stage of the landslide is considered to be between the initial and constant stages. At present, the early warning system mainly consists of six surface displacement monitoring sites and one water level observation site. If the daily recorded velocity in each monitoring site exceeds 4 mm/d and, meanwhile, the water level is below 1820 m above sea level (asl), a warning of likely landslide deformation accelerations will be released by relevant monitoring sites. The thresholds are always discretely exceeded on about 3% of annual monitoring days, and they are most frequently exceeded in June (especially in mid-June). The thresholds provide an efficient and effective way for judging accelerations of this landslide and are verified by the current application. The work presented provides critical insights into the development of early warning systems for reservoir-induced large-scale landslides.
Dynamic Lake Ice Movement on Lake Khovsgol, Mongolia, Revealed by Time Series Displacements from Pixel Offset with Sentinel-2 Optical Images
Authors: Zhang Jue , He Ping , Hu Xiaoping , Liu Zhumei
Published: December 2021

As one of the most sensitive indicators of global climate change, seasonal ice-covered lakes are attracting gaining attention worldwide. As a large seasonal ice-covered lake located in Northern Mongolia, Lake Khovsgol not only provides important freshwater resources for the local population but also serves as a means of water transportation in summer and an important land-based activity for residents in winter. In this study, we used the sub-pixel offset technique with multi-temporal Sentinel-2 optical images to estimate the time-series displacement of lake ice in Lake Khovsgol from 7 December 2020 to 17 June 2021. With the processing of 112 Sentinel-2 images, we obtained 27 pairs of displacement results at intervals of 5, 10, and 15 days. These lake ice movement results covered three stages from ice-on to ice-off. The first stage was the lake ice growth period, which lasted 26 days from 7 December 2020 to 3 January 2021. Ice formation started from the south and extended northward, with a displacement of up to 10 m in 5 days. The second stage was the active phase of the ice cover, which took place from 3 January 2021 to 18 April 2021. Maximum displacement values reached 12 m in the east and 11 m in the north among all observations. The value of the lake ice movement in the north–south direction (NS) was found to be larger than in the east–west direction (EW). The third stage was the melting period, which closed on 17 June 2021. In comparison to the freezing date of November in past years, our results demonstrate the ice-on date of Lake Khovsgol has been delayed to December, suggesting a possible reason that the seasonal ice-covered lake located at the middle latitude has been affected by global warming. In addition, the lake ice movement of our results can reveal the regional climate characteristic. This study is one of the few cases to reveal the distribution characteristics and changing trends of lake ice on the Mongolia Plateau, providing a rare reference for lake ice research in this region.
An Automatic Conflict Detection Framework for Urban Intersections Based on an Improved Time Difference to Collision Indicator
Authors: Li Qing , Lei Zhanzhan , Zhu Jiasong , Chen Jiaxin , Ma Tianzhu
Published: December 2021

Urban road intersections are one of the key components of road networks. Due to complex and diverse traffic conditions, traffic conflicts occur frequently. Accurate traffic conflict detection allows improvement of the traffic conditions and decreases the probability of traffic accidents. Many time-based conflict indicators have been widely studied, but the sizes of the vehicles are ignored. This is a very important factor for conflict detection at urban intersections. Therefore, in this paper we propose a novel time difference conflict indicator by incorporating vehicle sizes instead of viewing vehicles as particles. Specially, we designed an automatic conflict recognition framework between vehicles at the urban intersections. The vehicle sizes are automatically extracted with the sparse recurrent convolutional neural network, and the vehicle trajectories are obtained with a fast-tracking algorithm based on the intersection-to-union ratio. Given tracking vehicles, we improved the time difference to the conflict metric by incorporating vehicle size information. We have conducted extensive experiments and demonstrated that the proposed framework can effectively recognize vehicle conflict accurately.
Classifying Individual Shrub Species in UAV Images—A Case Study of the Gobi Region of Northwest China
Authors: Li Zhipeng , Ding Jie , Zhang Heyu , Feng Yiming
Published: December 2021

Shrublands are the main vegetation component in the Gobi region and contribute considerably to its ecosystem. Accurately classifying individual shrub vegetation species to understand their spatial distributions and to effectively monitor species diversity in the Gobi ecosystem is essential. High-resolution remote sensing data create vegetation type inventories over large areas. However, high spectral similarity between shrublands and surrounding areas remains a challenge. In this study, we provide a case study that integrates object-based image analysis (OBIA) and the random forest (RF) model to classify shrubland species automatically. The Gobi region on the southern slope of the Tian Shan Mountains in Northwest China was analyzed using readily available unmanned aerial vehicle (UAV) RGB imagery (1.5 cm spatial resolution). Different spectral and texture index images were derived from UAV RGB images as variables for species classification. Principal component analysis (PCA) extracted features from different types of variable sets (original bands, original bands + spectral indices, and original bands + spectral indices + texture indices). We tested the ability of several non-parametric decision tree models and different types of variable sets to classify shrub species. Moreover, we analyzed three main shrubland areas comprising different shrub species and compared the prediction accuracies of the optimal model in combination with different types of variable sets. We found that the RF model could generate higher accuracy compared with the other two models. The best results were obtained using a combination of the optimal variable set and the RF model with an 88.63% overall accuracy and 0.82 kappa coefficient. Integrating OBIA and RF in the species classification process provides a promising method for automatic mapping of individual shrub species in the Gobi region and can reduce the workload of individual shrub species classification.
The Role of Ambivalent Sexism, Punitiveness, and Ability to Recognize Violence in the Perception of Sex Offenders: A Gender-Perspective Analysis
Authors: Leon Carmen M. , Rollero Chiara
Published: December 2021

Sexual violence is a public health problem that affects not just the victim, but the offender and the surrounding communities. Research shows that public perceptions regarding the perpetrators of such offenses are of critical importance since citizens’ insights are a major force in the creation and implementation of sex offender policies. This study aimed to analyze, from a gender perspective, public perceptions about sex offenders in an Italian population sample (N = 768; 62.0% women, M = 32.8 years old). To do so, the Perceptions of Sex Offenders Scale (PSO) (α = 0.82) was used. The explanatory variables included in the study were the General Punitiveness Scale (GPS), the short versions of the Ambivalent Sexism Inventory (ASI), and the Ambivalence toward Men Inventory (AMI), as well as awareness about subtle forms of violence. Results showed that women reported higher levels of sex offenders’ risk perception. At the same time, it was found that men outscored women on the endorsement of stereotypes toward such perpetrators. Finally, findings revealed similarities and differences between women and men regarding correlates of perceptions about sex offenders. Implications for research and public policy in this area are discussed.
Enhancing the Method of Decentralized Multi-Purpose Reuse of Wastewater in Urban Area
Authors: Ghafoori Saeid , Hassanpour Darvishi Hossein , Mohamadvali Samani Hossein , Taherei Ghazvinei Pezhman
Published: December 2021

The reuse of treated wastewater is attractive as a communal source of excess water source in water-scarce counties and nations. The expansion of the urban population and the increase in the coverage of water supply networks and sewage networks will raise the amount of municipal sewage. This can turn into a new-fangled water resource. In the current research, the new campus city was selected as the first case study to design a wastewater reuse and recycling system. Accordingly, one of the most important innovations in the proposed research is the unique applied dimensions, in addition to its first-time performance, and the application of the Geo-land method in wastewater recycling as the theoretical dimension of the design. Clustering the decentralized reuse of wastewater for urban areas showed that significant parts of residential areas are located in the first high priority group. Urban planners can consider the results in establishing a comprehensive plan to prioritize the decentralized use of wastewater in the urban area.
Comparative Techno-Economic Analysis of Carbon Capture Processes: Pre-Combustion, Post-Combustion, and Oxy-Fuel Combustion Operations
Authors: Kheirinik Mahdi , Ahmed Shaab , Rahmanian Nejat
Published: December 2021

Evaluation of economic aspects is one of the main milestones that affect taking rapid actions in dealing with GHGs mitigation; in particular, avoiding CO2 emissions from large source points, such as power plants. In the present study, three kinds of capturing solutions for coal power plants as the most common source of electricity generation have been studied from technical and economic standpoints. Aspen HYSYS (ver.11) has been used to simulate the overall processes, calculate the battery limit, and assess required equipment. The Taylor scoring method has been utilized to calculate the costliness indexes, assessing the capital and investment costs of a 230 MW power plant using anthracite coal with and without post-combustion, pre-combustion, and oxy-fuel combustion CO2 capture technologies. Comparing the costs and the levelized cost of electricity, it was found that pre-combustion is more costly, to the extent that the total investment for it is approximately 1.6 times higher than the oxy-fuel process. Finally, post-combustion, in terms of maturity and cost-effectiveness, seems to be more attractive, since the capital cost and indirect costs are less. Most importantly, this can be applied to the existing plants without major disruption to the current operation of the plants.
Regional Features and Spatial Distribution of Fifty-Eight Ethnic Groups in Southwest China
Authors: Shen Yuan , Wang Danyin , Wu Jiahui , Yu Tianshu , Li Tao , Li Siyuan
Published: December 2021

Eco-environmental variability was the basis of ethnic diversity with a persistent influence on the regional development. The unique geographic conditions and multi-ethnic characteristics in southwest China were valuable for exploring sustainable development of ethnic regions. In this study, the regional features of distribution areas of ethnic groups in southwest China were analysed, and it was found that average altitude, slope, water coverage and water form ratio of each ethnic group differed apparently. Additionally, regional features of southern minorities were relatively stable, while those of northern minorities changed evidently from 1990 to 2010. Furthermore, taking the spatial coordinates and regional features as parameters, fifty-eight ethnic groups were clustered into six categories via spatial cluster analysis. Moreover, based on the county-level population data, the ethnic similarities in southwest China were identified by correlation analysis, and the results were in accordance with those of spatial cluster analysis but more detailed. In addition, the eco-environmental adaptability of various ethnic groups was discussed in terms of living and production as well as regional sustainable development. This research was of referential meaning for population settlement, natural resources utilization and biodiversity conservation in multi-ethnic regions.
Assessment of Tilapia–Freshwater Prawn Co-Culture Schemes in Tanks and Lake-Based Cages for Increased Farm Production
Authors: Romana-Eguia Maria Rowena Robles , Rutaquio Mildred Patito , Gutierrez Reylan Caroscos , Salayo Nerissa Diaz
Published: December 2021

The technical viability of tilapia (I-ExCEL strain Nile or red) and giant freshwater prawn (GFP) co-culture in cages-within-tanks was evaluated while appropriate feeding protocols for tilapia-GFP co-culture in cages in a eutrophic lake were determined. Specifically, production parameters in all test species grown for five months in tank co-culture (where only tilapias were fed) were compared, while the best feeding protocol from among the following treatments: (a) Tfed—fed tilapias; (b) GFPfed—fed prawns and (c) T-GFPfed—both species fed, were defined. I-ExCEL Nile tilapias grew faster in tank co-culture whether reared singly or otherwise. However, red tilapia-GFP tank co-culture gave the best results considering key production traits in all test species (red tilapia —2.52%/day specific growth rate or SGR, 83.3% survival; GFP—1.17%/day SGR, 72.85% survival). Lake-based co-culture was technically feasible at stocking densities of 12.5/m2 for tilapia and 2.4 to 4/m2 for prawns even when only tilapias were fed; prawns grew to desired marketable sizes by thriving mainly on detritus and natural food organisms in the lake. However, further refinements can still be made to optimise the co-culture schemes to make them more sustainable and provide artisanal fish farmers options in increasing farm yields through multi-species aquaculture.
Decoding Emergency Settlement through Quantitative Analysis
Authors: Dantas Abdon , Banh David , Heywood Philip , Amado Miguel
Published: December 2021

By the end of 2020, more than 80 million people were forcibly displaced around the world; this represents about one percent of the global population. Many of the displaced found shelter in emergency settlements; whether in refugee camps, IDP camps or community settlements. Some of these settlements are transitory, while others have been consolidated into permanent habitats; some span the size of a city, while others are the size of a village; some are well structured, while others provide only the bare minimum needed by residents. Notwithstanding these variations, there is still a lack of understanding of the range, depth, scale, and scope of these settlements. There is also a need for comparative analysis between different types of emergency settlements, as they are still generalized as temporary encampments. The aim of the study is to identify the distinctiveness of each type of emergency settlement to demonstrate that one strategy for their planning and management will not fit all. It does so by reviewing the criteria for analyzing emergency settlements around the world by using a quantitative analysis methodology on a set of variables considered relevant for the characterization of each typology based on a set of 500 cases. The results indicate that each type of emergency settlement has different characteristics and topology, and identify which variables, being identical, influence each typology differently. The article also discusses the basis for better-informed decision-making about the medium and long-term policies applicable to individual settlements.