bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer’s Disease
Authors: Butler Tracy , Wang Xiuyuan , Chiang Gloria , Xi Ke , Niogi Sumit , Glodzik Lidia , Li Yi , Razlighi Qolamreza Ray , Zhou Liangdong , Hojjati Seyed Hani , Ozsahin Ilker , Mao Xiangling , Maloney Thomas , Tanzi Emily , Rahmouni Nesrine , Tissot Cécile , Lussier Firoza , Shah Sudhin , Shungu Dikoma , Gupta Ajay , De Leon Mony , Mozley P. David , Pascoal Tharick A. , Rosa-Neto Pedro
Published: April 2024

Background: Alzheimer’s disease (AD) pathology is considered to begin in the brainstem, and cerebral microglia are known to play a critical role in AD pathogenesis, yet little is known about brainstem microglia in AD. Translocator protein (TSPO) PET, sensitive to activated microglia, shows high signal in dorsal brainstem in humans, but the precise location and clinical correlates of this signal are unknown. Objective: To define age and AD associations of brainstem TSPO PET signal in humans. Methods: We applied new probabilistic maps of brainstem nuclei to quantify PET-measured TSPO expression over the whole brain including brainstem in 71 subjects (43 controls scanned using 11C-PK11195; 20 controls and 8 AD subjects scanned using 11C-PBR28). We focused on inferior colliculi (IC) because of visually-obvious high signal in this region, and potential relevance to auditory dysfunction in AD. We also assessed bilateral cortex. Results: TSPO expression was normally high in IC and other brainstem regions. IC TSPO was decreased with aging (p = 0.001) and in AD subjects versus controls (p = 0.004). In cortex, TSPO expression was increased with aging (p = 0.030) and AD (p = 0.033). Conclusions: Decreased IC TSPO expression with aging and AD—an opposite pattern than in cortex—highlights underappreciated regional heterogeneity in microglia phenotype, and implicates IC in a biological explanation for strong links between hearing loss and AD. Unlike in cerebrum, where TSPO expression is considered pathological, activated microglia in IC and other brainstem nuclei may play a beneficial, homeostatic role. Additional study of brainstem microglia in aging and AD is needed.
Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer’s Disease
Authors: Cetinsoy Ozde , Anyanwu Ijeoma , Krishnanand Harikrishnan , Natarajan Gokulakrishnan , Ramachandran Naveen , Thomas Alan , Brookes Keeley J.
Published: April 2024

Background: The role of the innate immune system has long been associated with Alzheimer’s disease (AD). There is now accumulating evidence that the soluble Urokinase Plasminogen Activator Receptor pathway, and its genes, PLAU and PLAUR may be important in AD, and yet there have been few genetic association studies to explore this. Objective: This study utilizes the DNA bank of the Brains for Dementia Research cohort to investigate the genetic association of common polymorphisms across the PLAU and PLAUR genes with AD. Methods: TaqMan genotyping assays were used with standard procedures followed by association analysis in PLINK. Results: No association was observed between the PLAU gene and AD; however, two SNPs located in the PLAUR gene were indicative of a trend towards association but did not surpass multiple testing significance thresholds. Conclusions: Further genotyping studies and exploration of the consequences of these SNPs on gene expression and alternative splicing are warranted to fully uncover the role this system may have in AD.
Exploring Psychosis in Neurodegenerative Dementia: Connecting Symptoms to Neurobiology
Authors: Morrow Christopher B. , Pontone Gregory M.
Published: April 2024

The following commentary discusses a review by Cressot et al. entitled: ‘Psychosis in Neurodegenerative Dementias: A Systematic Comparative Review’. The authors describe the epidemiology and phenomenology of psychosis across neurodegenerative dementias. Dementia with Lewy bodies had the highest reported prevalence of psychosis at 74% followed by Alzheimer’s disease, 54% and frontotemporal degeneration, 42%. Detailed characterization of psychosis shows differences in the types of hallucinations and delusions by dementia type. These findings suggest that different types of dementia related pathology are associated with high rates of psychosis with more specific symptom profiles than previously appreciated. Understanding the differences and variety of psychotic experiences across dementia types may have diagnostic and therapeutic implications for treating hallucinations and delusions in populations suffering from neurodegenerative diseases.
RETRACTED: Fusion of Mask RCNN and multi-augmentation for rice recognition
Authors: Vu Hoai Nam , Nguyen Quang Dung , Nguyen Thuy Linh , Tran-Anh Dat
Published: April 2024

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
RETRACTED: Multi cascaded transformer network and hybrid heuristic-aided optimal bi-clustering mechanism for patent retrieval system using query expansion
Authors: David Raj G. , Mukherjee Saswathi , Jasmine R.L.
Published: April 2024

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
JUAL BELI DENGAN KLAUSULA BAKU DALAM PERSPEKTIF KOMPILASI HUKUM EKONOMI ISLAM
Authors: . Saifullah , . Hilda
Published: April 2024

Hasil penelitian ini menyimpulkan bahwa klausula baku menghilangkan prinsip dasar jual beli dalam Islam yaitu عن تراض منكم  karena menghilangkan hak khiyar. Hal tersebut terbukti dengan adanya catatan kecil dibagian bawah nota, dengan adanya catatan tersebut pembeli tidak memiliki jaminan pada barang yang telah dibeli apabila ada kecacatan pada barang tersebut.

Hasil penelitian ini diperkuat dengan hadits yang diriwayatkan “Dari Ibnu Umar ra. dari Rasulullah saw, bahwa beliau bersabda, “Apabila ada dua orang melakukan transaksi jual beli, maka masing-masing dari mereka (mempunyai) hak khiyar, selama mereka belum berpisah dan mereka masih berkumpul atau salah satu pihak memberikan hak khiyarnya kepada pihak yang lain. Namun jika salah satu pihak memberikan hak khiyar kepada yang lain lalu terjadi jual beli, maka jadilah jual beli itu, dan jika mereka telah berpisah sesudah terjadi jual beli itu, sedang salah seorang di antara mereka tidak (meninggalkan) jual belinya, maka jual beli telah terjadi (juga).” (HR. Al.Bukhari dan Muslim).
MULTI AKAD PADA PRAKTEK ARISAN ONLINE UNTUK PEMBELIAN JAM TANGAN (STUDI KASUS AKUN INSTAGRAM @SAFA.WATCH12)
Authors: Nopiyana Dina
Published: April 2024

This study aims to answer how the Islamic Law Review of Online Gathering for Purchasing Watches (Case Study of the Instagram Account @safa.watch12). This type of research is field research (Field Research). Based on the results of the research in terms of Islamic law, the arisan becomes valid if the goods obtained are in accordance with the arisan provisions, namely Alexandre Christie watches and the arisan law becomes invalid if the watch is replaced with another brand of course there is unwillingness because in the arisan provisions it is not permissible to resign so that participants received the hours that were available when getting the social gathering and did not match the initial deposit because the money from the gathering was mandated to buy only Alexandre Christie brand watches.

Keywords: Arisan Online, Buy and Sell, Islamic Law
COMMUNITY ECONOMIC EMPOWERMENT THROUGH INFAQ AND SHADAQAH IN LAZISMU CIREBON REGENCY SHARIA ECONOMIC LAW PERSPECTIVE
Authors: Rohmah Umdah Aulia
Published: April 2024

Infaq is Shorful Mal Ilal Hajah which has the meaning of managing or issuing assets to meet needs that are pleasing to Allah SWT. Sadaqah is part of the assets or non- assets issued by a person or in a business entity outside of zakat for the benefit of the community. The method used in this study is qualitative by utilizing phenomenological approach. Data collection techniques carried out, namely observation, interviews and documentation. From the results of his research obtained the Economic Empowerment of Infaq and Shadaqah Communities is by helping MSMEs with disabilities, both existing businesses or not having businesses at all. The economic impact is that it can help some people economically. Based on a review of Sharia Economic Law that community economic empowerment through Infaq and Sadaqah is an activity or program carried out by LAZISMU that is good and in line with Islamic law, because this activity or program is in accordance with the principle of monotheism, the principle of justice, the principle of honesty and truth, the principle of al-maslahah, and the principle of goodness contained in the principles of Sharia Economic Law.
Application of Ensemble Learning in CXR Classification for Enhancing COVID-19 Diagnosis
Authors: Rise Zeinab Rahimi , Ershadi Mohammad Mahdi
Published: April 2024

This study delves into the vital task of classifying chest X-ray (CXR) samples, particularly those related to respiratory ailments, using advanced clinical image analysis and computer-aided radiology techniques. Its primary focus is on developing a classifier to accurately identify COVID-19 cases. Through the application of machine learning and computer vision methodologies, the research aims to enhance the precision of COVID-19 detection. It investigates the effectiveness of Histogram of Oriented Gradients (HOG) feature extraction techniques in conjunction with various classifiers, such as Support Vector Machine (SVM), Decision Tree (DT), Naive Bayes (NB), K-nearest neighbor (KNN), and Tree Bagger (TB), alongside an innovative ensemble learning approach. Results indicate impressive accuracy rates, with KNN, SVM, DT, NB, and TB all surpassing the 90% mark. However, the ensemble learning method emerges as the standout performer. By leveraging HOG features extracted from CXR images, this approach presents a robust solution for COVID-19 diagnosis, offering a powerful tool to address the diagnostic challenges posed by the pandemic.
A Tracer Study on the Employment Status of Accounting and Finance Graduates from Furra College, Hawassa Campus, from 2009-2013 Ethiopian Calendars (E.C.)
Authors: Deyganto Kanbiro Orkaido , Abebe Addisu , Yure Mathewos , Dangiso Debebe
Published: April 2024

This tracer study focuses on the employment status of accounting and finance graduates from Furra College, Hawassa Campus, between 2009 and 2013 Ethiopian Calendars. The study adopts a pragmatic research philosophy, utilizing a combination of qualitative and quantitative research approaches to gather comprehensive data on the graduates' career outcomes. A descriptive research design is employed, with data collected through survey questionnaires and document reviews. Concerning the first specific objective, results show a high employment rate (80%) among graduates, with a significant portion (14%) engaged in entrepreneurship and a low unemployment rate (6%). In relation to the second specific objective, the findings from the survey of accounting and finance graduates from Furra College, Hawassa Campus, reveal a high level of job satisfaction among those employed in the accounting field. Based on the responses from the 15 purposively selected employers, it is evident that they are highly satisfied with the knowledge, skills, and attitude exhibited by accounting and finance graduates from the years 2009-2013 E.C. The study highlights the importance of quality education, support for entrepreneurship, and addressing unemployment issues to ensure the continued success and growth of graduates in the field. Generally, the study presents a promising outlook for accounting and finance graduates from Furra College, while also identifying areas for further improvement to sustain their success in the job market.
Applying the Theory of Planned Behavior in Sexuality Education: Educators’ Behavioral Intentions toward Sexuality Issues
Authors: Grigoropoulos Iraklis
Published: April 2024

Grounded on Ajzen’s theory of planned behavior (1991), the current project in two studies (_N _= 402) examined Greek and Spanish pre-service early childhood educators’ behavioral intentions (i.e., approach and avoidance intentions) toward young children’s sexual curiosities. Specifically, the current research project aimed to examine whether Greek and Spanish pre-service early childhood educators’ views on sexuality education were linked to their behavioral intentions toward children’s sexual curiosities. The current research also examined whether conservative ideology (religiosity and right-wing political orientation) moderates the link between educators’ views and their behavioral intentions. This study’s findings showed that educators’ views influence their behavioral intentions toward children’s curiosity about sexual issues. In addition, moderation analysis showed religiosity’s underlying role in avoidance intention. This result provides evidence that there are theoretical and empirical grounds to assume that conservative worldviews (i.e., religiosity) significantly influence behavioral intentions concerning sexuality education. The theory of planned behavior not only represents the factors influencing intention but also provides an opportunity to comprehend the impacts of contextual and individual background elements that may be relevant to a particular behavior.
THE IMPACT OF GAME-BASED LEARNING ON COGNITIVE DEVELOPMENT IN EARLY CHILDHOOD: A REVIEW OF THE LITERATURE
Authors: Annuar Haerul , Solihatin Etin , Khaerudin Khaerudin
Published: April 2024

This study aims to investigate the impact of game-based learning on cognitive development in early childhood through a literature review. Game-based learning has become a major focus in early childhood education because of its potential to stimulate children's cognitive development. Through a comprehensive literature review, this article describes various findings from previous research that reveal the impact of game-based learning on cognitive abilities such as problem-solving, critical thinking skills, conceptual understanding, and flexible thinking abilities in early childhood. These findings provide insight into how this learning approach can influence children's cognitive development at an early stage in their lives. Practical implications and future research directions are also discussed in this article. Thus, this article provides a better understanding of the importance of integrating play-based learning in early childhood education curricula to improve children's cognitive development.
THE APPLICATION OF SCHOOL-BASED MANAGEMENT IN EMPOWERING THE COMPETENCY OF MAHYAL ULUM ACEH VOCATIONAL SCHOOL TEACHERS
Authors: Jalaluddin  , Nuhari Insan , Marwan  , Umami Khairiati
Published: April 2024

The goal achieved is to find out the implementation of school-based management, know the variety of empowerment of teacher potential, and know the supporting and inhibiting factors of the implementation of school-based management in empowering teacher competencies at Mahyal Ulum Aceh Besar Vocational School. The type of research used is qualitative which is descriptive. The data collection methods used are observation, interviews and documentation. The data analysis technique is a qualitative descriptive analysis, namely data reduction, data presentation, data interpretation, and conclusion. The results showed that the implementation of SBM in the empowerment of teacher competencies was carried out well because of the cooperation between the principal, teachers and staff. This is seen in terms of teacher competence in curriculum management, teacher competencies in education staff management, teacher competencies in student management, teacher potential in financial management, as well as the potential of teachers in providing facilities and infrastructure. The supporting factors are first, government support in the form of providing BOS funds, allocation of local government funds and granting authority in school management. Second, teacher support in the form of teaching staff who are qualified Undergraduate and Masters certified teachers. And third, student support in the form of an increasing number of students and voluntary assistance from students' parents. The inhibiting factors are infrastructure and funds are still limited and the role of the community is not yet optimal.
EXPLORING MULTI-REPRESENTATION LEARNING APPROACH IN MATHEMATICS ELEMENTARY SCHOOL STUDENTS
Authors: Faujiah Evi , Yurniwati  , Yarmi Gusti
Published: April 2024

The purpose of this study was to analyze the effectiveness of the multi-representation learning approach in improving the understanding of mathematical concepts for elementary school students. The inclusion criteria in this review include studies that clearly apply a multi-representation approach in primary school settings and have relevant data to evaluate. Studies that do not provide adequate data or do not meet the inclusion criteria are excluded. Sources of information used to identify these studies include various academic databases such as ERIC, Springer, Elsevier, Ebschoohost, Taylor &; Francis, the ACM Technical Symposium on Computer Science Education and MDPI publishers. The last search was conducted last month before the writing of this abstract. Methods of evaluating bias risk in included studies include methodological quality assessment, data quality control, and evaluation of the accuracy of the statistical analysis used. The main findings of the study are presented through thematic and narrative analysis, with a total of 75 scientific studies included in this review. The characteristics of relevant studies will be discussed further in the analysis which includes research content, study design, type of participants, learning domain, and year of publication. The findings show that with various forms of representation students can improve their understanding of mathematics from informal to formal levels, in addition to the fact that multi-representation learning can deepen students' understanding of complex mathematical concepts.
INNOVATION WITHIN LIMITATION: BATIK CREATION BY DISABILITIES STUDENTS
Authors: Abdullah Farid , Adnan Aneeza Mohd , Wardoyo Tri , Effendi Harris , Badaruddin Mohammed Iqbal
Published: April 2024

The creation of batik among disabled students with sensory limitations is still very limited. Disabled people are often considered inferior by society as a group that needs to be pitied, has limited abilities, and is unproductive. This stigma is very detrimental to people with disabilities, has negative connotations, and is counter-productive. This article uses a descriptive - qualitative method for students with disabilities at Griya Batik Difabel, Social Service, West Java Province, in creating written batik. A number of innovative steps were taken for students with disabilities to produce hand-written batik cloth. Innovation in aspects of ideas, tools, batik creation processes, displays, and introducing batik products to the wider community. The findings from this paper are that students with disabilities have high innovation abilities in creating written batik cloth. The written batik works of students with disabilities have a number of advantages in terms of innovation in ideas for motifs, designs, color compositions, including the display of the batik final work. The innovation of creating written batik created by students with disabilities is very important to be appointed, presented and shown to society as a form of fair recognition as a human being
ICT TRENDS IN EDUCATION: A BIBLIOMETRICS STUDY OF THE PAST TWENTY YEARS OF STUDIES
Authors: Mardianti Fani , Liliawati Winny , Sinaga Parlindungan , Wandi Wandi
Published: April 2024

Technology is a major component in education. Therefore, it must be investigated in order to gather knowledge for additional study. 185 articles were assessed using the PRISMA approach in conjunction with VOS-Viewer via Scopus data collecting. Analysing the quantity of articles, nations, citations, journals, and research partnerships on digital assessment in education is how evaluation is done. Knowledge map analysis is another way to investigate co-occurrence mapping. According to the research findings, the number of articles published rises annually, with the UK having the highest number of published publications. The research with the most citations is "Affordances of ICT in science learning: Implications for an integrated pedagogy," the journal with the most publications is "International Journal of Science Education," and the most well-liked partnership is the work done in Germany and the United Kingdom. The author with the most citations is "Webb M.E." Additionally, cluster analysis indicates that there are five primary categories—computer science education, education, science education, teaching, and science learning—that are most closely related to one another. Teaching, education, and computer science education are hot subjects right now.
THE MEANING OF LEARNING IN VIRTUAL CLASSROOMS: STUDY OF THE UTILIZATION OF DRILL MODELS AND PRACTICES IN SDIK NURUL QURAN
Authors: Nafis Badratun , Fatianda Septian , Fitriani  , Liiman Monadia , Astryna Syarifah Yanti
Published: April 2024

In this research, the problem is that there are still teachers and students who do not understand ICT while the facilities in the school already support to use of the drill and practice model, in addition, the drill and practice model is not suitable to be applied in all subjects. The drill and practice learning model are one of the learning models that use ICT to train students' skills in applying the concepts, knowledge, and skills that students have through speed in solving problems and providing hands-on training and experience to students. The purpose of this research is to know the utilization of drill and practice models so that looters are more meaningful improve the effectiveness of student learning during online learning and know the use of ICT to students with teachers in using drill and practice models. This type of research uses a qualitative approach with a case study research method and data analysis technique through observation and interview of SDIK Nurul Quran teacher. The results showed that SDIK Nurul Quran has used drill and practice models in the learning process, and facilities in schools strongly support the application of drill and practice models using Information and Communication Technology. Based on the results of this drill and practice model research can improve the effectiveness of student learning and learning feels more meaningful during online learning.
PENGARUH SHIFT KERJA TERHADAP KINERJA PEGAWAI DENGAN MOTIVASI SEBAGAI VARIABEL INTERVENING DI RUMAH SAKIT SITI AISYAH KOTA LUBUKLINGGAU
Authors: Hartono Budi , Tafdhi Ikhwanul , Sastrawinata Hendra
Published: April 2024

Masalah pada penelitian ini adalah 1) Adakah pengaruh shift kinerja terhadap kerja pegawai di Rumah Sakit  Siti Aisyah Kota Lubuklinggau?, 3) Adakah pengaruh shift kerja terhadap kinerja pegawai melalui motivasi sebagai Variabel Intervening di Rumah Sakit  Siti Aisyah Kota Lubuklinggau?. Tujuan penelitian ini adalah 1) Untuk mengetahui pengaruh shift kerja terhadap kinerja pegawai di Rumah Sakit  Siti Aisyah Kota Lubuklinggau. 22) Untuk mengetahui pengaruh shift kerja terhadap kinerja pegawai  melalui motivasi sebagai Variabel Intervening di Rumah Sakit  Siti Aisyah Kota Lubuklinggau. Jenis penelitian adalah kuantitatif. Pengambilan sampel menggunakan sampel jenuh yaitu sebanyak 57 orang.  Pengumpulan  data dilakukan dengan angket. Analisis data menggunakan uji moderast. Hasil penelitian adalah 1) Ada pengaruh shift kerja terhadap kinerja pegawai di Rumah Sakit  Siti Aisyah Kota Lubuklinggau.. Dapat dilihat dari hasil perhitungan thitung sebesar 6,259 menunjukan nilai ttabel sebesar 2,057 sehingga dengan demikian bahwa thitung > ttabel. 2) Ada pengaruh shift kerja terhadap kinerja pegawai  melalui motivasi sebagai Variabel Intervening di Rumah Sakit  Siti Aisyah Kota Lubuklinggau sebesar 0,098 atau 9,8%.
Лобода Ю. Г. Вебтехнології та вебдизайн : метод. вказівки до виконання лабораторних та самостійних робіт для здобувачів вищої освіти галузі знань 12 «Інформаційні технології» [Електронне видання]
Authors:   Національний університет «Одеська юридична академія», Лобода Ю. Г. , Сурілова О. Ю.
Published: April 2024

Методичні вказівки містять завдання до лабораторних і самостійних робіт. Призначені для здобувачів вищої освіти галузі знань 12 «Інформаційні технології» з метою закріплення лекційного матеріалу і підготовки до лабораторних робот з дисципліни «Вебтехнології та вебдизайн».
Моделювання програмного забезпечення : навч.-метод. посіб. [Електронний ресурс]
Authors:   Національний університет «Одеська юридична академія», Манаков С. Ю. , Трофименко О. Г. , Лобода Ю. Г. , Дика А. І.
Published: April 2024

Навчально-методичний посібник призначений для підготовки до лабораторних і самостійних робіт, які виконуються в рамках навчальної дисципліни, присвяченої вивченню фундаментальних основ моделювання програмного забезпечення майбутніми ІТ-спеціалістами. Розглянуто сучасні підходи до моделювання програмного забезпечення та засоби для реалізації цих підходів. Наведено завдання до 8 лабораторних і 8 самостійних робіт, які дозволяють дослідити набір діаграм сучасних CASE-засобів моделювання програмних продуктів і навчитися розробляти організаційні, функціональні, інформаційні та процесні моделі предметної області для програмного забезпечення. Для студентів вищих навчальних закладів, науковців і спеціалістів з моделювання програмного забезпечення.
Задерейко О. В, Лобода Ю. Г. Аналіз складних систем : навч. посіб. [Електронне видання]
Authors:   Національний університет «Одеська юридична академія», Задерейко Олександр Владиславович , Лобода Юлія Геннадіївна
Published: April 2024

Навчальний посібник присвячено вивченню проблем аналізу складних систем інформаційного спрямування. Посібник містить загальні основи поняттєвого апарату складних систем різних типів. Розглянуто методологію аналізу сучасних інформаційно-комп'ютерних систем; наведено базові технології щодо діагностики інформаційно-комп'ютерних систем з точки зору забезпечення їх захищеності від потенційних витоків даних. Призначений для спеціалістів у галузі системного анализу, а також викладачів вищих навчальних закладів, студентів і аспірантів, які спеціалізуються у сфері аналізу систем різної складності та призначення.
PARECERISTAS DE 2019
Authors: Equipe Editorial
Published: April 2024

Relação dos pareceristas externos do ano de 2019.
Justifying Limitations on Freedom of Expression for Contempt of Religion
Authors: Waheduzzaman Moha
Published: April 2024

In the recent past, there have been the cases of making abusive remarks against Prophet Muhammad, drawing cartoons of him, and burning the Holy Quran in public. These incidents no doubt outrage the religious feelings of people belonging to the religion of Islam. Besides this, they also contribute to violence and riot and the consequential deaths of people around the world. There are, however, literatures which seek to justify these conducts having a very liberal and extended view of the right to freedom of expression. They argue as if there should not be any limitation on freedom of expression so far that relates to contempt of any religion. I argue that freedom of expression howsoever valuable that might be, is a qualified as opposed to an unqualified human right. Hence, its exercise cannot extend to making abusive remarks against religious personages or defiling or burning the Holy Book(s) of any religion. If it is acknowledged by all including the relevant stakeholders of the United Nations, this might help reducing the chances of human casualties and deaths of people caused by alleged blasphemous conducts with respect to any religion. Foreseeing this significance, I aim to revisit the justification and limits of freedom of expression in the backdrop of contempt of religion.

Dhaka University Law Journal, 2023, 34 (2), 43-65
Calidad microbiológica de la carne de pollo expendida en el Mercado Mayorista Miguel Grau del distrito de Tacna
Authors: Nina Inchuña Mónica Santamaría
Published: April 2024

Objetivo: Determinar la calidad microbiológica de la carne de pollo expendida en el Mercado Mayorista Miguel Grau del distrito de Tacna.Material y métodos: El tamaño muestral estuvo conformado por 75 muestras, se contempló lo dictaminado en la Norma Sanitaria Peruana que establece los criterios microbiológicos de calidad sanitaria e inocuidad para los alimentos y bebidas de consumo humano (Norma Técnica de Salud N°071 – MINSA/DIGESA-V.01) del año 2008, aplicando a cada muestra, el método Recuento Estándar en Placa de aerobios mesófilos, de acuerdo con la metodología de la Comisión Internacional de Especificaciones Microbiológicas en Alimentos (ICMSF); así mismo, la investigación de Salmonella spp, bajo el método AOAC 2014.01. Sistema PetrifilmTM Salmonella Express.Resultados: Se determinó, con el método Recuento Estándar en Placa, que el 17,33 % de las muestras excedieron el límite permisible referente a aerobios mesófilos.Con respecto a la investigación de Salmonella spp, el Sistema PetrifilmTM permitió confirmar su presencia en 14,67 % del total de muestras analizadas. Conclusión: Se concluyó que la calidad microbiológica de 23 muestras representada por el 30,67 % no cumplen con los criterios microbiológicos establecidos en la normativa peruana vigente considerándose no apto para el consumo humano.
Tricobezoar en edad pediátrica
Authors: Carpio Cornejo Juan , Franco Perochena Paola
Published: April 2024

Los bezoares son cuerpos extraños conglomerados de pelo, fibras vegetales, medicamentos y otras sustancias en el tracto gastrointestinal; usualmente están asociados a desordenes de la conducta. El objetivo del tratamiento es su remoción, asociado a la prevención de la recurrencia. Se presenta casos clínicos de dos pacientes mujeres, una de 11 y otra de 12 años, que luego de los diferentes exámenes auxiliares y la evaluación médica, fueron sometidas a laparotomía exploratoria, precediendo a extracción de tricobezoar.
The Development of a Conceptual Framework for 21st Century Teaching Competency
Authors: Laohajaratsang Thanomporn , Arsarkij Janejira , Maotheuak Surasak
Published: April 2024

This research aimed to 1) analyze and synthesize teaching competency in the 21st century for teachers conceptual framework, and 2) develop and validate the 21st century teaching competency conceptual framework and assessment tools. Research methods included the analysis and synthesis of the concept of teaching competency in the 21st century. Nine experts in the relevant fields were requested to assess the standard of evaluation and quality of the 21st century teaching competency conceptual framework and the 21st century teaching competency assessment tools. The research instruments used to collect qualitative and quantitative data were the standard evaluation assessment form and quality assessment form to validate the conceptual framework of the 21st century teaching competency, and the 21st century teaching competency assessment tools which included the self-assessment form, the observation form, and the portfolio assessment form, and interview form. Analysis of the data used in this study included mean, standard deviation and content analysis. The study results of the analysis and synthesis of the 21st century teaching competency framework for teachers evaluated by nine experts, were found to have a very high level of standard evaluation with an average of 4.85 (SD 1.53), and a very high level the conceptual framework quality, with an average of 4.85 (SD 0.28). In conclusion, the 21st century teaching competency conceptual framework and assessment tools were developed and validated at a very high level of quality and standard evaluation. The experts confirmed that the 21st century teaching competency framework is a practical and comprehensive framework for assessing teaching competency in the 21st century.
PEMBAHARUAN PEMIKIRAN ISLAM MODEL MUHAMMADIYAH DAN NAHDLATUL ULAMA
Authors: Arroisi Jarman , Perdana Martin Putra , Hutama Reza
Published: April 2024

Muhammadiyah and NU are two of the largest Islamic organization in Indonesia. Both of these organizations have significant mass and inter-related to each other. These organizations stand up long before the independence of Indonesia announced. Muhammadiyah itself was founded by Kyai Ahmad Dahlan and Nahdlatul Ulama Hasyim was initiated by Kyai Ash'ari. Sincerity and the struggle of its founder, who make this great organization can exist and be accepted by the community to this day. The organization is also a symbol of strength of the Islamic organizations in Indonesia. The two religious organizations also does little merit in the fight for Indonesia's independence. Although many of the negative view that menyasar him but did not make the harmony both fade. It is visible from their struggle in propagating dakwahnya in Indonesia with sincere and full of struggle. Da’wah movement not only focused in purification of belief but also plays a role in answering the problems that exist in society. By using the methods to critical review I tried to dig the closeness between the Muhammadiyah and Nahdlatul Ulama which can not be disputed again.
Mental Health: A Study of Al-Kindi’s Philosophical Thoughts of The Soul
Authors: Puspita Rana Indah
Published: April 2024

Mental health for every individual, starting from the family, school, workplace, to the general public has become the main focus at this time. In 2020, when the massive spread of the COVID-19 virus, many people's mental health was disturbed. In the current condition of society, it appears that the mental health of each individual cannot be generalized. Good health enables people to realize their potential, cope with the normal stresses of life, work productively and contribute to their communities. Al-Kindi is a philosopher who is very tenacious in carrying out his shari'at. One of the philosophies studied by Al-Kindi is the philosophy of the soul. The purpose of this study is to find out preventive measures that can be taken to avoid mental illness. This research uses a type of qualitative research, based on library research (literary study). The research approach used in this article is a historical approach and a philosophical approach. This study uses a rationalistic approach with comparative analysis techniques, namely comparing one reference with another. The conclusion of this research is when you want a calm soul, you have to use rational (reason). Because desire and love are sensuous will experience destruction and annihilation. Meanwhile, rational love is always eternal and constant and does not experience destruction and loss. That's why, people who want to be happy and prevent themselves from being disturbed by sadness, then he must make his love and desire in the rational world not in the sensory world.
Harmonizing Fiqh Education with Local Wisdom: Enhancing Students' Religious Awareness via Teacher-Parent Collaboration
Authors: Lubis Winda Nurul Hazizah , Arlina Arlina
Published: April 2024

This research aims to determine the collaboration between fiqh teachers and parents in increasing students' awareness of worship at MTs Istiqlal Deli Tua. This research is qualitative research with a descriptive approach. This research was carried out at MTs Istiqlal Deli Tua with research subjects namely fiqh teachers, parents and students. Data collection techniques in this research were carried out using interviews, observation and documentation. Meanwhile, the data analysis used is qualitative which is carried out through several stages, namely data collection, data reduction and drawing conclusions. The results of this research are the collaboration between fiqh teachers and parents in increasing students' awareness of worship at MTs Istiqlal Deli Tua, namely teacher interaction with students, advising children, providing good role models, inviting and practicing, giving gifts as a form of appreciation and giving punishment. From the research results, it appears that fiqh teachers have a big role in guiding students in worship and providing good role models. The implication is the need to strengthen the role of fiqh teachers as models and spiritual guides for students.
Guardian Foster Service Program: Patterns of Handling Student Bullying Using An Ethnoparenting Approach
Authors: Wibowo Adi , Nurmalasari Ita
Published: April 2024

This research aims to analyze the Guardian Care Service Program as a strategy for handling student bullying by implementing an ethnoparenting approach in Islamic boarding schools. Qualitative research methods were used to gain an in-depth understanding of how foster carers involve cultural values in handling bullying cases and guiding students according to the local context. Research findings show that the Foster Care Service Program is an approach that responds to cultural dynamics in Islamic boarding schools, where foster carers play a central role in creating a safe and supportive environment. This program integrates local cultural and ethical values in developing santri, creates contextual anti-bullying policies, and increases community involvement. The results of this research provide valuable insight regarding the effectiveness of the ethnoparenting approach in overcoming bullying and supporting students' positive growth in the Islamic boarding school environment. The implications of these findings can help develop similar programs in traditional Islamic educational institutions and contribute to further understanding regarding the role of foster carers and ethnoparenting approaches in creating an educational environment that is inclusive, safe, and based on local cultural values.
Calligraphy Learning: Analysis of Guidance at Al-Quran Calligraphy Studio
Authors: Insani Erikafatul , Anam Nurul
Published: April 2024

This research aims to provide a solution to the complex and challenging nature of learning calligraphy, preserve the art of calligraphy, and be able to provide achievements to students in the field of calligraphy art and play an essential role as a stimulator that stimulates the development of competent human resources in preserving Islamic cultural treasures in the form of calligraphy art. This research uses a qualitative approach with a case study type of research in Dar el-Khat Jember. Data collection was carried out through observation and interviews based on in-depth studies. The research results show that Dar el-Khat Jember has several unique lessons compared to other calligraphy art studios. This is revealed by the existence of three types of guidance, including (1) Guidance on the Introduction to the History of Al-Qur'an Calligraphy, (2) Guidance on Pure Calligraphy Learning, (3) Guidance on the development of applied calligraphy skills. Learning Al-Qur'an calligraphy at Dar el-Khat Jember makes it easier for students to learn Al-Qur'an calligraphy, increases mastery of various types of calligraphy, preserves the art of calligraphy, and stimulates the development of competent human resources in maintaining the art of calligraphy and Islamic culture.
In vitro antifungal activity of Ricinus communis and Cyperus rotundus on Colletotrichum gloeosporioides strains
Authors: Chan-Cupul Wilberth , Manzo-Sánchez Gilberto , Buenrostro-Nava Marco Tulio , Sánchez-Rangel Juan Carlos
Published: April 2024

Background: Colletotrichum gloeosporioides causes anthracnose in various agricultural crops.
Objective: To evaluate the antifungal activity of Ricinus communis and Cyperus rotundus against WSFT and Tainung strains of C. gloeosporioides, comparing them with commercial products containing Bacillus subtilis (Serenade®) and Streptomyces spp. (Blite Free®).
Methods: Inhibition percentages were determined through a dose-response bioassay with Serenade® and Blite Free® and the ethanolic extracts of R. communis and C. rotundus on the strains of C. gloeosporioides isolated from Carica papaya.
Results and conclusions: R. communis induced higher mycelial inhibition (62.7 %) in the Tainung strain compared to Serenade® (54.2 %) and Blite Free® (0 %). The EC50 values obtained in the WSFT strain were similar between R. communis (0.80 %) and Serenade® (0.79 %). The antifungal activity of the plant extracts proved comparable to that of commercial products, suggesting their potential for controlling C. gloeosporioides.
Updates on traditional methods for combating malaria and emerging Wolbachia-based interventions
Authors: Mushtaq Iqra , Sarwar Muhammad Sajjad , Chaudhry Ammara , Shah Syed Ali Haider , Ahmad Muhammad Mubeen
Published: April 2024

The escalating challenge of malaria control necessitates innovative approaches that extend beyond traditional control strategies. This review explores the incorporation of traditional vector control techniques with emerging Wolbachia-based interventions. Wolbachia, a naturally occurring bacteria, offers a novel approach for combatting vector-borne diseases, including malaria, by reducing the mosquitoes’ ability to transmit these diseases. The study explores the rationale for this integration, presenting various case studies and pilot projects that have exhibited significant success. Employing a multi-dimensional approach that includes community mobilization, environmental modifications, and new biological methods, the paper posits that integrated efforts could mark a turning point in the struggle against malaria. Our findings indicate that incorporating Wolbachia-based strategies into existing vector management programs not only is feasible but also heightens the efficacy of malaria control initiatives in different countries especially in Pakistan. The paper concludes that continued research and international collaboration are imperative for translating these promising methods from the laboratory to the field, thereby offering a more sustainable and effective malaria control strategy.
Analysis of slope stochastic fields using a novel deep learning model with attention mechanism
Authors: Ma Ning , Yao Zaizhen
Published: April 2024

This paper proposes a novel deep learning model incorporating attention mechanisms for the analysis of slope stochastic fields. Initially, a deep learning model is designed to digitally image the stochastic field features of soil strength variability. This is achieved by discretizing the slope soil stochastic field using the Karhunen-Loeve expansion method and transforming the discrete results into digital images. These images are then used to establish a Convolutional Neural Network (CNN) surrogate model that maps the implicit relationship between stochastic field images and slope functional function values, thus calculating the probability of slope failure. The precision of the CNN surrogate model is enhanced through Bayesian optimization and five-fold cross-validation. Moreover, to overcome the limitations of existing data-driven landslide stability prediction models, this study also introduces a Spatial-Temporal Attention (STA) mechanism. By combining the CNN with Long Short-Term Memory (LSTM) networks, the model can accurately approximate the actual results of slope stability calculations in scenarios of high-dimensional representation imaging of stochastic fields and low-probability slope instability. Consequently, this significantly improves the computational efficiency of slope reliability analysis considering stochastic field simulations.
RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis
Authors: Xiong Yan , Li Yanan , Qian Weiwei , Zhang Qing
Published: April 2024

The Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality. Although most infections are mild, some patients can also develop severe and fatal myocarditis. In eukaryotic RNAs, 5-methylcytosine (m5C) is a common kind of post-transcriptional modification, which is involved in regulating various biological processes (such as RNA export, translation, and stability maintenance). With the rapid development of m5C modification detection technology, studies related to viral m5C modification are ever-increasing. These studies have revealed that m5C modification plays an important role in various stages of viral replication, including transcription and translation. According to recent studies, m5C methylation modification can regulate SARS-CoV-2 infection by modulating innate immune signaling pathways. However, the specific role of m5C modification in SARS-CoV-2-induced myocarditis remains unclear. Therefore, this review aims to provide insights into the molecular mechanisms of m5C methylation in SARS-CoV-2 infection. Moreover, the regulatory role of NSUN2 in viral infection and host innate immune response was also highlighted. This review may provide new directions for developing therapeutic strategies for SARS-CoV-2-associated myocarditis.
Proteomics data in vitiligo: a scoping review
Authors: Berrevoet Danique , Van Nieuwerburgh Filip , Deforce Dieter , Speeckaert Reinhart
Published: April 2024

An unbiased screening of which proteins are deregulated in vitiligo using proteomics can offer an enormous value. It could not only reveal robust biomarkers for detecting disease activity but can also identify which patients are most likely to respond to treatments. We performed a scoping review searching for all articles using proteomics in vitiligo. Eight manuscripts could be identified. Unfortunately, very limited overlap was found in the differentially expressed proteins between studies (15 out of 272; 5,51%) with variable degrees of the type of proteins and a substantial variety in the prevalence of acute phase proteins (range: 6-65%). Proteomics research has therefore brought little corroborating evidence on which proteins are differentially regulated between vitiligo patients and healthy controls or between active and stable vitiligo patients. While a limited patient size is an obvious weakness for several studies, an incomplete description of patient characteristics is an unfortunate and avoidable shortcoming. Additionally, the variations in the used methodology and analyses may further contribute to the overall observed variability. Nonetheless, more recent studies investigating the response to treatment seem to be more robust, as more differentially expressed proteins that have previously been confirmed to be involved in vitiligo were found. The further inclusion of proteomics analyses in clinical trials is recommended to increase insights into the pathogenic mechanisms in vitiligo and identify reliable biomarkers or promising drug targets. A harmonization in the study design, reporting and proteomics methodology could vastly improve the value of vitiligo proteomics research.