bluuebunny/crossref_metadata_2025 huggingface dataset:
Goal Attainment in an Individually Tailored and Home-Based Intervention in the Chronic Phase after Traumatic Brain Injury
Authors: Borgen Ida M. H. , Hauger Solveig L. , Forslund Marit V. , Kleffelgård Ingerid , Brunborg Cathrine , Andelic Nada , Sveen Unni , Søberg Helene L. , Sigurdardottir Solrun , Røe Cecilie , Løvstad Marianne
Published: February 2022

Traumatic brain injury (TBI) is a heterogeneous condition with long-term consequences for individuals and families. Goal-oriented rehabilitation is often applied, but there is scarce knowledge regarding types of goals and goal attainment. This study describes goal attainment in persons in the chronic phase of TBI who have received an individualized, SMART goal-oriented and home-based intervention, compares goal attainment in different functional domains, and examines indicators of goal attainment. Goal attainment scaling (GAS) was recorded in the intervention group (n = 59) at the final session. The goal attainment was high, with 93.3% increased goal attainment across all goals at the final session. The level of goal attainment was comparable across domains (cognitive, physical/somatic, emotional, social). Gender, anxiety symptoms, self-reported executive dysfunction, and therapy expectations were indicators of goal attainment. These results indicate a potential for the high level of goal attainment in the chronic phase of TBI. Tailoring of rehabilitation to address individual needs for home-dwelling persons with TBI in the chronic phase represents an important area of future research.
Severe Asthma, Telemedicine, and Self-Administered Therapy: Listening First to the Patient
Authors: Guarnieri Gabriella , Caminati Marco , Achille Alessia , Vaia Rachele , Chieco Bianchi Fulvia , Senna Gianenrico , Vianello Andrea
Published: February 2022

Severe asthma patients are at an increased risk of major complications and they need to be monitored regularly. The COVID-19 pandemic has notably impacted on the health care resources. The telemedicine approach applied to the follow-up of asthmatic patients has been proven to be effective in monitoring their disease and their adherence to the therapy. The aim of our study was to investigate the satisfaction of severe asthma patients before the activation of a telemedicine management, as well as their current experience with self-administration of injection therapy. An ad hoc questionnaire was developed and sent by e-mail to 180 severe asthma patients. Most of subjects, 82%, were confident with the idea of doing self-measurements and self-managing their disease. Further, 77% of subjects favoured to carry out virtual visits and telemedicine. Regarding the home treatment, 93% of patients considered the self-injection therapy easy, 94% of subjects felt safe, and 93% were not worried while self-administering. Only mild adverse events were reported in 22% of patients after self-administration. Our results showed an agreement between what is considered necessary and practicable by healthcare personnel and what is perceived by the severe asthma patients in terms of treatment and monitoring of the disease with Telehealth. Biologics have a safety profile and can be easily self-administred at home.
Increased Oxygen Extraction by Pulmonary Rehabilitation Improves Exercise Tolerance and Ventilatory Efficiency in Advanced Chronic Obstructive Pulmonary Disease
Authors: Miyazaki Akito , Miki Keisuke , Maekura Ryoji , Tsujino Kazuyuki , Hashimoto Hisako , Miki Mari , Yanagi Hiromi , Koba Taro , Nii Takuro , Matsuki Takanori , Kida Hiroshi
Published: February 2022

Background: In cardiopulmonary exercise testing (CPET), oxygen uptake (V’O2) is calculated using the product of minute ventilation (V’E) and the difference between inspiratory and expiratory O2 concentrations (ΔFO2). However, little is known about the response of ΔFO2 to pulmonary rehabilitation (PR). The aim of the present study was (1) to investigate whether PR increases peak V’O2, based on whether ΔFO2 or V’E at peak exercise increase after PR, and (2) to investigate whether an improvement in ΔFO2 correlates with an improvement in ventilatory efficiency. Methods: A total of 38 patients with severe and very severe COPD, whose PR responses were evaluated by CPET, were retrospectively analyzed. Results: After PR, peak V’O2 was increased in 14 patients. The difference in ΔFO2 at peak exercise following PR correlated with the difference in peak V’O2 (r = 0.4884, p = 0.0019), the difference in V’E/V’CO2-nadir (r = −0.7057, p < 0.0001), and the difference in V’E–V’CO2 slope (r = −0.4578, p = 0.0039), but it did not correlate with the difference in peak V’E. Conclusions: The increased O2 extraction following PR correlated with improved exercise tolerance and ventilatory efficiency. In advanced COPD patients, a new strategy for improving O2 extraction ability might be effective in those in whom ventilatory ability can be only minimally increased.
Clinical Relevance of Liver Involvement in the Clinical Course of Systemic Sclerosis
Authors: Lorena Maria , Bellan Mattia , Lepore Maia , Sola Daniele , Pedrazzoli Roberta , Rigamonti Cristina , De Benedittis Carla , Manfredi Giulia Francesca , Acquaviva Antonio , Tonello Stelvio , Rizzi Manuela , Minisini Rosalba , Pirisi Mario , Sainaghi Pier Paolo
Published: February 2022

Liver involvement in systemic sclerosis (SSc) is rare. We evaluated the prevalence of liver fibrosis and hepatic autoimmunity in SSc patients in a retrospective observational cohort (97 SSc or mixed connective tissue disease with sclerodermic manifestations patients undergoing transient elastography, evaluating liver stiffness (LS) and controlled attenuation parameter (CAP), due to clinical indications along with biochemistry assessments and major antibodies associated to liver autoimmunity). Among them, 11 had LS ≥ 7.5 kPa and 5 showed an LS compatible with cirrhosis (LS ≥ 12.5 kPa). Predictors of LS ≥ 7.5 fibrosis were alcohol consumption (>14 or >7 alcoholic units/week for men and women, respectively), waist circumference (>102 or >88 cm for men and women, respectively), elevated alkaline phosphatase, and anti-La and anti-mitochondrial antibody (AMA) positivity. Six patients had CAP values compatible with severe steatosis (≥280 dB/m). Waist circumference, body mass index and diabetes mellitus were significant predictors of steatosis. Out of 97 patients, 19 were positive for AMA, 4 for anti-Sp100, 1 for anti-Gp210 and 7 were diagnosed with primary biliary cholangitis. Among SSc patients, hepatic fibrosis biomarkers and AMA prevalence are relatively high, suggesting the opportunity of performing a transient elastography and a screening for hepatic autoimmunity at diagnosis and/or during disease progression.
Urine Nerve Growth Factor May Not Be Useful as a Biomarker of Overactive Bladder in Patients with Pelvic Organ Prolapse
Authors: Jankiewicz Katarzyna , Bogusiewicz Michał , Nowakowski Łukasz , Rechberger Tomasz , Rogowski Artur , Miotla Pawel
Published: February 2022

(1) Background: Overactive bladder (OAB) symptoms are frequently present in women with pelvic organ prolapse (POP). Although urinary nerve growth factor (NGF) is a promising biomarker of OAB, little is known about its role in patients with OAB secondary to POP. The aim of the study was to evaluate urinary NGF levels in patients with POP involving the anterior vaginal wall and check if it may serve as a predicting factor for postoperative resolution of OAB symptoms. (2) Methods: Eighty-three Caucasian women included in the study were divided into three groups: pure OAB, one associated with POP (POP&OAB) and a control group composed of healthy volunteers. The urine NGF and creatinine were assessed with ELISA tests to calculate the NGF/creatinine ratio. (3) Results: The NGF/creatinine ratio was significantly higher in patients with pure OAB in comparison with other groups; however, it did not differ between the control group and the POP&OAB group. There was no correlation between NGF/creatinine ratio and age, menopausal status, BMI, parity or urodynamic findings. The NGF/creatinine ratio was not a prognostic factor for OAB symptoms’ resolution after surgical treatment of POP. (4) Conclusions: Urinary NGF excretion is not increased in women with OAB secondary to POP; thus, it may not serve as an OAB biomarker in these patients.
Effectiveness and Safety of Transcatheter Atrial Septal Defect Closure in Adults with Systemic Essential Hypertension
Authors: Świątkiewicz Iwona , Bednarczyk Łukasz , Kasprzak Michał , Laskowska Ewa , Woźnicki Marek
Published: February 2022

Concomitant systemic essential hypertension (HTN) in adults with a secundum atrial septal defect (ASD) can unfavorably affect the hemodynamics and transcatheter ASD closure (ASDC) effects. This study aims to assess the effectiveness and safety of ASDC in adults with HTN in real-world clinical practice. Right ventricular (RV) reverse remodeling (RVR) and the lack of a left-to-right interatrial residual shunt (NoRS) in echocardiography 24 h and 6 months (6 M) post-ASDC, and ASDC-related complications within 6 M were evaluated in 184 adults: 79 with HTN (HTN+) and 105 without HTN (HTN−). Compared to HTN−, HTN+ patients were older and had a greater RV size and the prevalence of atrial arrhythmias, chronic heart failure, nonobstructive coronary artery disease, diabetes, hyperlipidemia, and left ventricular diastolic dysfunction. ASDC was successful and resulted in RVR, NoRS, and a lack of ASDC-related complications in the majority of HTN+ patients both at 24 h and 6 M. HTN+ and HTN− did not differ in ASD size, a successful implantation rate (98.7% vs. 99%), RVR 24 h (46.8% vs. 46.7%) and 6 M (59.4% vs. 67.9%) post-ASDC, NoRS 24 h (79% vs. 81.5%) and 6 M (76.6% vs. 86.9%) post-ASDC, and the composite of RVR and NoRS at 6 M (43.8% vs. 57.1%). Most ASDC-related complications in HTN+ occurred within 24 h and were minor; however, major complications such as device embolization within 24 h and mitral regurgitation within 6 M were observed. No differences between HTN+ and HTN− were observed in the total (12.7% vs. 9.5%) and major (5.1% vs. 4.8%) complications. Transcatheter ASDC is effective and safe in adults with secundum ASD and concomitant HTN in real-world clinical practice; however, proper preprocedural management and regular long-term follow-up post-ASDC are required.
Chinese Admission Warning Strategy for Predicting the Hospital Discharge Outcome in Patients with Traumatic Brain Injury
Authors: Zheng Ruizhe , Zhuang Zhongwei , Zhao Changyi , Zhao Zhijie , Yang Xitao , Zhou Yue , Pan Shuming , Chen Kui , Li Keqin , Huang Qiong , Wang Yang , Ma Yanbin
Published: February 2022

Objective: To develop and validate an admission warning strategy that incorporates the general emergency department indicators for predicting the hospital discharge outcome of patients with traumatic brain injury (TBI) in China. Methods: This admission warning strategy was developed in a primary cohort that consisted of 605 patients with TBI who were admitted within 6 h of injury. The least absolute shrinkage and selection operator and multivariable logistic regression analysis were used to develop the early warning strategy of selected indicators. Two sub-cohorts consisting of 180 and 107 patients with TBI were used for the external validation. Results: Indicators of the strategy included three categories: baseline characteristics, imaging and laboratory indicators. This strategy displayed good calibration and good discrimination. A high C-index was reached in the internal validation. The multicenter external validation cohort still showed good discrimination C-indices. Decision curve analysis (DCA) showed the actual needs of this strategy when the possibility threshold was 0.01 for the primary cohort, and at thresholds of 0.02–0.83 and 0.01–0.88 for the two sub-cohorts, respectively. In addition, this strategy exhibited a significant prognostic capacity compared to the traditional single predictors, and this optimization was also observed in two external validation cohorts. Conclusions: We developed and validated an admission warning strategy that can be quickly deployed in the emergency department. This strategy can be used as an ideal tool for predicting hospital discharge outcomes and providing objective evidence for early informed consent of the hospital discharge outcome to the family members of TBI patients.
Volanesorsen: A New Era in the Treatment of Severe Hypertriglyceridemia
Authors: Kolovou Genovefa , Kolovou Vana , Katsiki Niki
Published: February 2022

Introduction: Familial chylomicronemia syndrome (FCS) is a rare inherited disease, mainly due to lipoprotein lipase (LPL) gene mutations, leading to lipid abnormalities. Volanesorsen, a second-generation 2′-O-methoxyethyl (2′-MOE) chimeric antisense therapeutic oligonucleotide, can decrease plasma apolipoprotein C3 and triglycerides (TG) levels through LPL-independent pathways. The European Medicines Agency has approved volanesorsen as an adjunct to diet in adult FCS patients with an inadequate response to TG-lowering therapy. Areas covered: Available clinical data on volanesorsen efficacy and safety are presented. Furthermore, we discuss the yearly treatment with volanesorsen of a 21-year-old female FCS patient with LPL mutation. Volanesorsen was well-tolerated and decreased patient’s TG levels (from >5000 mg/dL (56 mmol/L) to 350–500 mg/dL (4–5.6 mmol/L)) at 12 months. Lipoprotein apheresis (LA) was stopped and there were no episodes of pancreatitis or abdominal pain. Expert opinion: Severe hypertriglyceridemia can potentially be fatal. Until recently, there was no specific treatment for FCS, apart from hypotriglyceridemic diet, fibrates, omega-3 fatty acids, and LA sessions. Therefore, volanesorsen represents a promising therapeutic solution for these patients. The main side effect of volanesorsen therapy is thrombocytopenia, which should be monitored and treated accordingly. Increasing evidence will further elucidate the clinical implications of volanesorsen use in daily practice.
Hybrid FPGA–CPU-Based Architecture for Object Recognition in Visual Servoing of Arm Prosthesis
Authors: Fejér Attila , Nagy Zoltán , Benois-Pineau Jenny , Szolgay Péter , de Rugy Aymar , Domenger Jean-Philippe
Published: February 2022

The present paper proposes an implementation of a hybrid hardware–software system for the visual servoing of prosthetic arms. We focus on the most critical vision analysis part of the system. The prosthetic system comprises a glass-worn eye tracker and a video camera, and the task is to recognize the object to grasp. The lightweight architecture for gaze-driven object recognition has to be implemented as a wearable device with low power consumption (less than 5.6 W). The algorithmic chain comprises gaze fixations estimation and filtering, generation of candidates, and recognition, with two backbone convolutional neural networks (CNN). The time-consuming parts of the system, such as SIFT (Scale Invariant Feature Transform) detector and the backbone CNN feature extractor, are implemented in FPGA, and a new reduction layer is introduced in the object-recognition CNN to reduce the computational burden. The proposed implementation is compatible with the real-time control of the prosthetic arm.
Effects of AR Picture Books on German Teaching in Universities
Authors: Gu Chao , Chen Jiangjie , Yang Chun , Wei Wei , Jiang Qianling , Jiang Liao , Wu Qiuhong , Lin Shu-Yuan , Yang Yunshuo
Published: February 2022

In this paper, we discuss the teaching effects of augmented reality (AR) technology in German instruction. We conducted one prestudy and three formal studies on German learners in China’s mainland and Taiwan region. In the formal studies, a total of 120 students participated in the survey, allowing us to compare the differences in interest in learning between AR picture books and traditional picture books. A total of 114 students took part in the survey, which enabled us to compare the contribution of AR picture books to teaching when students’ satisfaction and German proficiency were different. To improve satisfaction, 514 students participated in the survey regarding the influence of the interactive narrative design effect and peer learning on satisfaction with using AR picture books. The results suggest that when learning German with AR picture books, satisfaction is the key construct that determines students’ learning states.
DSCU: Accelerating CNN Inference in FPGAs with Dual Sizes of Compute Unit
Authors: Bao Zhenshan , Guo Junnan , Zhang Wenbo , Dang Hongbo
Published: February 2022

FPGA-based accelerators have shown great potential in improving the performance of CNN inference. However, the existing FPGA-based approaches suffer from a low compute unit (CU) efficiency due to their large number of redundant computations, thus leading to high levels of performance degradation. In this paper, we show that no single CU can perform best across all the convolutional layers (CONV-layers). To this end, we propose the use of dual sizes of compute unit (DSCU), an approach that aims to accelerate CNN inference in FPGAs. The key idea of DSCU is to select the best combination of CUs via dynamic programming scheduling for each CONV-layer and then assemble each CONV-layer combination into a computing solution for the given CNN to deploy in FPGAs. The experimental results show that DSCU can achieve a performance density of 3.36 × 10−3 GOPs/slice on a Xilinx Zynq ZU3EG, which is 4.29 times higher than that achieved by other approaches.
Intestine Explants in Organ Culture: A Tool to Broaden the Regenerative Studies in Echinoderms
Authors: Bello Samir A. , García-Arrarás José E.
Published: February 2022

The cellular events underlying intestine regrowth in the sea cucumber Holothuria glaberrima have been described by our group. Currently, the molecular and signaling mechanisms involved in this process are being explored. One of the limitations to our investigations has been the absence of suitable cell culture methodologies, required to advance the regeneration studies. An in vitro system, where regenerating intestine explants can be studied in organ culture, was established previously by our group. However, a detailed description of the histological properties of the cultured gut explants was lacking. Here, we used immunocytochemical techniques to study the potential effects of the culture conditions on the histological characteristics of explants, comparing them to the features observed during gut regeneration in our model in vivo. Additionally, the explant outgrowths were morphologically described by phase-contrast microscopy and SEM. Remarkably, intestine explants retain most of their original histoarchitecture for up to 10 days, with few changes as culture time increases. The most evident effects of the culture conditions on explants over culture time were the reduction in the proliferative rate, the loss of the polarity in the localization of proliferating cells, and the appearance of a subpopulation of putative spherulocytes. Finally, cells that migrated from the gut explants could form net-like monolayers, firmly attached to the culture substrate. Overall, regenerating explants in organ culture represent a powerful tool to perform short-term studies of processes associated with gut regeneration in H. glaberrima under controlled conditions.
Investigating the Acceptance of a New Bivalve Product in the Greek Shellfish Market: The Non-Indigenous Pearl Oyster Pinctada imbricata radiata
Authors: Moutopoulos Dimitrios K. , Minasidis Vasileios , Ziou Athina , Douligeri Alexandra S. , Katselis George , Theodorou John A.
Published: February 2022

Greece exhibits the lowest seafood per capita consumption amongst European Mediterranean countries, and the investigation of consumer attitudes to new seafood products would bridge the gap among producers and consumers by promoting the vertical integration of the supply chain. However, limited information exists about consumer preferences for bivalves in the Mediterranean and for wild bivalves in particular. The present study aims to investigate, for the first time, consumers’ attitudes towards the purchase and consumption of bivalves, and more specifically, towards the edible pearl oyster Pinctada imbricata radiata, in the Greek shellfish market. Adult participants from the entire country completed a questionnaire covering the basic marketing aspects of bivalve and pearl oyster consumption, such as choice, purchase, reasons for consuming bivalves, confidence in product’s hygiene certification, media influence, etc. Data analysis included uni- and multi-variate statistics to examine the possible relations between the consumers’ demographics and socio-economic characteristics, and bivalve marketing aspects. Results showed that the majority of Greek consumers chooses traditional shellfish shops for purchasing pearl oysters, prefers a certification of quality, and trusts the confirmation provided by the veterinary authorities. Consumers’ attitudes vary considerably according to their demographics and socio-economic characteristics. Multivariate models revealed that the married, highly educated consumers that live in urban places were more reluctant to try new shellfish products and to accept an innovative way of market supply. The results reflect the positive attitude of Greek consumers towards the consumption of pearl oyster, a fact that would be helpful for decision makers in the planning of production, which in turn would promote bivalve consumption in the Greek shellfish market.
Mechanisms in Growth-Promoting of Cucumber by the Endophytic Fungus Chaetomium globosum Strain ND35
Authors: Tian Yehan , Fu Xuesong , Zhang Gongchen , Zhang Rui , Kang Zhensheng , Gao Kexiang , Mendgen Kurt
Published: February 2022

Endophytic fungi are effective in plant growth and development by secreting various kinds of plant hormones and nutrients. However, the cellular and molecular interactions between the endophytic fungi and plant growth-promoting have remained less explored. The present study was designed to explore the effects of the infection and colonization events of Chaetomium globosum strain ND35 on cucumber growth and the expression pattern of some metabolically important genes in development of the cucumber radicle. The results demonstrated that strain ND35 can infect and colonize the outer layers (cortical cells) of cucumber root and form a symbiotic structure with the host cell, similar to a periarbuscular membrane and establish chemical communication with the plant. Through transcriptome analysis, we found the differentially expressed genes (DEGs) caused by strain ND35 were mainly enriched in phenylpropanoid biosynthesis, plant hormone signal transduction, plant-pathogen interaction and photosynthesis. Correspondingly, the contents of reactive oxygen species (ROS), hydrogen peroxide (H2O2), indole-3-acetic acid (IAA), gibberellin (GA), zeatin (ZT), salicylic acid (SA), jasmonic acid (JA) and the activity of phenylalanine ammonia lyase (PAL), 4-coumarate-CoA ligase (4CL), cinnamyl alcohol dehydrogenase (CAD), and peroxidase (POD) in ND35-colonized seedlings were generally higher than those of non-inoculated seedlings. Overall, the infection and colonization events of C. globosum strain ND35 increased cucumber growth through complex regulation of plant hormones biosynthesis and metabolism. Furthermore, although the endophytic fungus strain ND35 produced IAA, GA, ZT, and ergosterol in the fermentation broth, and there are enabled to promote growth of cucumber, it is uncertain whether there are ND35-derived microbial hormones in plants. This study of the interaction between cucumber and strain ND35 contributes to a better understanding of the plant-endophytic fungi interactions, and may help to develop new strategies for crop production.
Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida parapsilosis
Authors: Hare Rasmus Krøger , Arastehfar Amir , Rosendahl Søren , Charsizadeh Arezoo , Daneshnia Farnaz , Eshaghi Hamid , Mirhendi Hossein , Boekhout Teun , Hagen Ferry , Arendrup Maiken Cavling
Published: February 2022

Candida parapsilosis is the second most common cause of candidemia in some geographical areas and in children in particular. Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran. As this species is also known to cause hospital outbreaks, we explored if the relatively high number of C. parapsilosis pediatric cases in Tehran could in part be explained by undiscovered clonal outbreaks. Among 56 C. parapsilosis complex isolates, 50 C. parapsilosis were genotyped by Amplified Fragment Length Polymorphism (AFLP) fingerprinting and microsatellite typing and analyzed for nucleotide polymorphisms by FKS1 and ERG11 sequencing. AFLP fingerprinting grouped Iranian isolates in two main clusters. Microsatellite typing separated the isolates into five clonal lineages, of which four were shared with Danish isolates, and with no correlation to the AFLP patterns. ERG11 and FKS1 sequencing revealed few polymorphisms in ERG11 leading to amino-acid substitutions (D133Y, Q250K, I302T, and R398I), with no influence on azole-susceptibilities. Collectively, this study demonstrated that there were no clonal outbreaks at the Iranian pediatric ward. Although possible transmission of a diverse C. parapsilosis community within the hospital cannot be ruled out, the study also emphasizes the necessity of applying appropriately discriminatory methods for outbreak investigation.
When Viruses Meet Fungi: Tackling the Enemies in Hematology
Authors: Busca Alessandro , Marchesi Francesco , Cattaneo Chiara , Trecarichi Enrico Maria , Delia Mario , Del Principe Maria Ilaria , Candoni Anna , Pagano Livio
Published: February 2022

The association of invasive fungal infections (IFI) and viral infections has been described in patients with hematologic malignancies (HM), in particular in hematopoietic stem cell transplant recipients. Regrettably, the diagnosis is often challenging, making the treatment inappropriate in some circumstances. The present review takes into consideration the viral infections commonly associated with IFI. Clinical presentation of IFI and viral infections, risk factors, and impact on the outcome of HM patients are discussed throughout the paper.
Fourteen New Species of Foliar Colletotrichum Associated with the Invasive Plant Ageratinaadenophora and Surrounding Crops
Authors: Yu Zefen , Jiang Xinwei , Zheng Hua , Zhang Hanbo , Qiao Min
Published: February 2022

Ageratina adenophora is one of the most invasive weeds in China. Following an outbreak in Yunnan in the 1960s, A. adenophora has been spreading in Southwest China at tremendous speed. Previous research indicated A. adenophora contained many Colletotrichum species as endophytes. In this study, we investigated the diversity of Colletotrichum in healthy and diseased leaves of the invasive plant A. adenophora and several surrounding crops in Yunnan, Guangxi, and Guizhou provinces in China, and obtained over 1000 Colletotrichum strains. After preliminary delimitation using the internal transcribed spacer region (ITS) sequences, 44 representative strains were selected for further study. Their phylogenetic positions were determined by phylogenetic analyses using combined sequences of ITS, actin (ACT), chitin synthase (CHS-1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and beta-tubulin (TUB2). Combined with morphological characteristics, 14 new Colletotrichum species were named as C. adenophorae, C. analogum, C. cangyuanense, C. dimorphum, C. gracile, C. nanhuaense, C. nullisetosum, C. oblongisporum, C. parvisporum, C. robustum, C. simulanticitri, C. speciosum, C. subhenanense, and C. yunajiangense.
Serotonin-Related Functional Genetic Variants Affect the Occurrence of Psychiatric and Motor Adverse Events of Dopaminergic Treatment in Parkinson’s Disease: A Retrospective Cohort Study
Authors: Redenšek Sara , Blagus Tanja , Trošt Maja , Dolžan Vita
Published: February 2022

The serotonergic system is important in Parkinson’s disease (PD) pathogenesis as it can take over dopamine production after a large portion of dopaminergic neurons is lost through neurodegeneration. The aim of this study was to evaluate the effect of genetic variability of serotonergic genes on the occurrence of motor complications and psychiatric adverse events (AE) due to dopaminergic treatment. We enrolled 231 patients and their clinical data were collected. Genotyping was performed for eight genetic variants. Logistic regression was used for analysis. Carriers of the HTR1A rs6295 GC genotype (OR = 2.58; 95% CI = 1.15–5.78; p = 0.021), TPH2 rs4290270 AA genotype (OR = 2.78; 95% CI = 1.08–7.03; p = 0.034), and at least one TPH2 rs4570625 T allele (OR = 1.86; 95% CI = 1.00–3.44; p = 0.047) had increased risk for visual hallucinations (VH). Additionally, carriers of at least one SLC6A4 5-HTTPLR rs25531 S (OR = 0.52; 95% CI = 0.28–0.96; p = 0.037) or at least one LG allele (OR = 0.37; 95% CI = 0.14–0.97; p = 0.044) had a decreased chance for VH. Constructed haplotypes of the TPH2 showed increased risk for VH (OR = 1.94; 95% CI = 1.06–3.55; p = 0.032) and impulse control disorders (OR = 5.20; 95% CI = 1.86–14.50; p = 0.002). Finally, individual gene–gene interactions showed decreased odds for the development of motor AE. Our findings suggest that the serotonergic pathway may play an important role in the development of AE resulting from dopaminergic treatment.
Patients’ Perceptions of Pharmacogenetic Testing and Access to Their Results: State of the Art in Spain and Systematic Review
Authors: Zubiaur Pablo , Prósper-Cuesta David Nicolás , Novalbos Jesús , Mejía-Abril Gina , Navares-Gómez Marcos , Villapalos-García Gonzalo , Soria-Chacartegui Paula , Abad-Santos Francisco
Published: February 2022

The process of clinical pharmacogenetics implementation depends on patients’ and general population’s perceptions. To date, no study has been published addressing Spanish patients’ opinions on pharmacogenetic testing, the availability of the results, and the need for signing informed consent. In this work, we contacted 146 patients that had been previously genotyped at our laboratory and 46 healthy volunteers that had participated in a bioequivalence clinical trial at the Clinical Pharmacology Department of Hospital Universitario de La Princesa and consented to pharmacogenetic testing for research purposes. From the latter, 108 and 34, respectively, responded to the questionnaire (i.e., a response rate of 74%); Participants were scheduled for a face-to-face, telephone, or videoconference interview and were asked a total of 27 questions in Spanish. Great or almost complete acceptance of pharmacogenetic testing was observed (99.3%), age and university education level being the main predictors of acceptance rates and understanding (multivariate analysis, p = 0.004, R2 = 0.17, age being inversely proportional to acceptance rates and understanding and university level being related to higher acceptance rates and understanding compared to other education levels). Mixed perceptions were observed on the requirement of written informed consent (55.6% in favor); therefore, it seems recommendable to continue requesting it for the upcoming years until more perceptions are collected. The majority of participants (95.8%) preferred storing pharmacogenetic results in medical records rather than in electronic sources (55.6%) and highly agreed with the possibility of carrying their results on a portable card (91.5%). Patients agreed to broad genetic testing, including biomarkers unrelated to their disease (93.7%) or with little clinically relevant evidence (94.4%). Patients apparently rely on clinician’s or pharmacogeneticist’s interpretation and seem, therefore, open to the generation of ethically challenging information. Finally, although most patients (68.3%) agreed with universal population testing, some were reluctant, probably due to the related costs and sustainability of the Spanish Health System. This was especially evident in the group of patients who were older and with a likely higher proportion of pensioners.
Clinical Observation of SGLT2 Inhibitor Therapy for Cardiac Arrhythmia and Related Cardiovascular Disease in Diabetic Patients with Controlled Hypertension
Authors: Jhuo Shih-Jie , Lin Tsung-Hsien , Lin Yi-Hsiung , Tsai Wei-Chung , Liu I-Hsin , Wu Bin-Nan , Lee Kun-Tai , Lai Wen-Ter
Published: February 2022

Sodium-glucose transporter 2 (SGLT2) inhibitors are new glucose-lowering agents that have been proven to be beneficial for patients with cardiovascular diseases, heart failure, and sudden cardiac death. However, the possible protective effects of cardiac arrhythmia have not yet been clarified in clinical practice. In this study, we attempted to demonstrate the effects of SGLT2 inhibitors on cardiac arrhythmia by medical records from a single center. This retrospective study included patients diagnosed with type 2 diabetes mellitus (DM) and controlled hypertension who prescribed the indicated glucose-lowering agents based on medical records from 2016 to 2019 from Kaohsiung Medical University Hospital. These patients were divided into two groups. Group one patients were defined as patients with SGLT2 inhibitor therapy, and group two patients were defined as patients without SGLT2 inhibitor therapy. Baseline characteristics were collected from medical records. Univariate, multivariate, and match-paired statistical analyses were performed for the study endpoints. The primary study outcome was the incidence of cardiac arrhythmias, including atrial and ventricular arrhythmias, after SGLT2 inhibitor therapy. The secondary study outcomes were the incidence of stroke, heart failure, and myocardial infarction after SGLT2 inhibitor therapy. From the initial 62,704 medical records, a total of 9609 people who met our experimental design criteria were included. The mean follow-up period was 51.50 ± 4.23 months. Group one included 3203 patients who received SGLT2 inhibitors for treatment, and group two included 6406 patients who received non-SGLT2 inhibitors for treatment. Multivariate analysis showed that group one patients had significantly lower incidences of total cardiac arrhythmia (hazard ratio (HR): 0.58, 95% confidence interval (CI): 0.38–0.89, p = 0.013) and atrial fibrillation (HR: 0.56, 95% CI: 0.35–0.88, p = 0.013) than those of group two patients. The secondary outcome analysis showed that group one patients also had a significantly lower risk of stroke (HR: 0.48, 95% CI: 0.33–0.7; p < 0.001), heart failure (HR: 0.54, 95% CI: 0.41–0.7, p < 0.001), and myocardial infarction (HR: 0.47, 95% CI: 0.31–0.72, p < 0.001). A time-to-event analysis showed that treatment of type 2 DM patients with SGLT2 inhibitors could reduce the probability of total cardiac arrhythmia and related cardiovascular disease, such as atrial fibrillation, stroke, heart failure, or myocardial infarction, by 0.5%~0.8%. This databank analysis showed that SGLT2 inhibitor therapy reduced the incidence of total cardiac arrhythmia and atrial fibrillation in type 2 DM patients and decreased the incidence of related cardiovascular diseases, such as stroke, heart failure, and myocardial infarction. However, additional investigations are needed to confirm this hypothesis.
A Comprehensive Analysis of Recent Deep and Federated-Learning-Based Methodologies for Brain Tumor Diagnosis
Authors: Naeem Ahmad , Anees Tayyaba , Naqvi Rizwan Ali , Loh Woong-Kee
Published: February 2022

Brain tumors are a deadly disease with a high mortality rate. Early diagnosis of brain tumors improves treatment, which results in a better survival rate for patients. Artificial intelligence (AI) has recently emerged as an assistive technology for the early diagnosis of tumors, and AI is the primary focus of researchers in the diagnosis of brain tumors. This study provides an overview of recent research on the diagnosis of brain tumors using federated and deep learning methods. The primary objective is to explore the performance of deep and federated learning methods and evaluate their accuracy in the diagnosis process. A systematic literature review is provided, discussing the open issues and challenges, which are likely to guide future researchers working in the field of brain tumor diagnosis.
Role of Service Quality, Price, and Firm Image on Customer Satisfaction in Philippine Accounting Firms
Authors: Brucal Sandra , Corpuz Cris , Abeysekera Indra , David Raul
Published: February 2022

This study examines the service quality of accounting firms in Pampanga, Philippines, and their customers’ satisfaction. Using the SERVQUAL model, the study explores the effect of service quality, price, and firm image on client satisfaction of accounting firms. The study conducted a field survey questionnaire using convenience sampling and collected 59 client-firm responses. The findings suggest that accounting firm clients are satisfied with the services they receive from their respective providers. Regression analysis indicates that service quality significantly affects only customer satisfaction. Price has a significant effect on service quality. The duration a client stays with the firm and services provided to the client also significantly impact controlling service quality. Additional testing shows that service quality mediates the influence of service price on customer satisfaction. The findings guide accounting firms to improve their client service quality.
Reflections on the KDIGO Definition of Acute Kidney Injury and Its Integration in the Concept of Acute Diseases and Disorders and Chronic Kidney Diseases
Authors: Lameire Norbert
Published: February 2022

Acute kidney injury (AKI) describes a heterogeneous group of conditions, without specification of their etiology and diagnosed only by indirect markers of glomerular filtration rate (GFR), such as serum creatinine and urine output. Bedside estimation of GFR and detection of structural alterations with novel biomarkers, and stress tests have more recently been developed. These novel findings should probably be included in future AKI definitions. Chronic kidney disease (CKD) is defined by abnormalities in kidney function and structure that persist over >3 months and is classified according to cause, GFR, and albuminuria. Acute kidney disease (AKD) is the term representing patients with abnormalities of function and structure with a duration of ≤3 months that fall outside the definitions of AKI or CKD. Since AKI is by definition also AKD, 2 types of AKD have been proposed, one with and one without AKI. AKD without AKI is common, often undetected, occurs frequently in the outpatient population and shows increased risk of CKD, ESKD and mortality. Alternatively, AKD has also been defined as the period of incomplete recovery following an AKI episode, the latter limited for the duration of 7 days. This contribution discusses the pros and cons of the existence of these 2 definitions of AKD.
Incomplete Urbanization and the Trans-Local Rural-Urban Gradient in China: From a Perspective of New Economics of Labor Migration
Authors: Liu Ran
Published: February 2022

The urbanization in China is “incomplete” and the migration of non-hukou migrants is circular, wherein rural migrants often keep their rural land in the home village as a social safety net. The informal housing market is one of the main housing providers for migrant workers. Existing studies see informal housing as the migrants’ passive choice under the discriminatory hukou system, while underplaying the migrants’ familial multi-site tenure strategies between village homes and city places. As suggested by New Economics of Labor Migration (NELM), attachment to a place of origin (such as keeping hometown lands), while choosing informal housing at the destination, is a familial utility maximization strategy that can control risks when migrating between locations. Informal housing areas, therefore, become a trans-local rural-urban gradient and semi-urban landscape. We use the 2017 Migrant Dynamics Monitoring Survey data and the binary logistic regression to examine (a) whether hometown landowning is a significant predictor of the migrants’ choosing of a temporary stay in informal settlements in urban destinations, and (b) which kind of hometown land arrangement (farmland or homestead holding or both of them) is the strongest indicator of the higher probability of staying in informal settlements in urban destinations? The data analysis reveals that homestead in hometown is a more prominent pulling factor than farmland to “glue” rural migrants together within an integrated rural land “insurance regime” between the migrant-sending and -receiving places. The land-use and informal housing governance (including urban village demolition) ignore the trans-local nature of the migratory networks and semi-urbanizing dynamics. The traditional analysis of the rural-urban gradient with many landscapes should consider the functional and tenurial linkage between the locations at different points along with the complex migration activities.
Identification of Land Use Function Bundles and Their Spatiotemporal Trade-Offs/Synergies: A Case Study in Jiangsu Coast, China
Authors: Huang Sihua , Wang Yuan , Liu Rongjuan , Jiang Yu , Qie Lu , Pu Lijie
Published: February 2022

Land use multifunctionality (LUMF) is a pragmatic means of resolving land use conflicts and realising regional sustainability and has critical importance in land system science. In this study, we constructed LUMF classifications from a sustainable perspective and quantified and analysed the deliveries of land use functions (LUFs) in the coastal area of Jiangsu Province, China. On this basis, the “bundle” concept was innovatively introduced into the LUMF research framework to analyse the spatiotemporal effects of trade-offs and synergies among multiple LUFs. The results showed that high-value LUF geographic units tended to cluster in human-dominated landscapes. During the study period (2000–2018), the average provision of regional multifunction increased slightly, while the subfunctions changed in different trends. Four LUF bundles (agricultural zone, mosaic cropland–rural housing zone, coastal natural and seminatural landscape zone, urban development zone) were identified, each having different dominant LUFs and landscape configurations. In each LUF bundle, the most common trade-offs were observed in the environmental and economic functions. The space incompatibilities caused by land development demand in different subregions created a trade-off and synergy among multiple functions. Moreover, LUF relations were not static over time, owing to the effects of urbanisation, coastal reclamation activities, and agriculture protection policies. Based on the above results, this research proposes land use optimisations for different multifunctional areas.
ARTFit—A Quick and Reliable Tool for Performing Initial Fittings in Users of MED-EL Cochlear Implants
Authors: Gärtner Lutz , Bräcker Timo , Kals Mathias , Penninger Richard T. , Billinger-Finke Mareike , Lenarz Thomas , Büchner Andreas
Published: February 2022

This study assessed the safety and performance of ARTFit, a new tool embedded in MAESTRO, the cochlear implant (CI) system software by MED-EL GmbH (Innsbruck, Austria). ARTFit automatically measures thresholds of the electrically evoked compound action potential (ECAP) to produce initial ‘maps’ (ECAPMAPs), i.e., configuration settings of the audio processor that the audiologist switches to live mode and adjusts for comfortable loudness (LiveECAPMAPs). Twenty-three adult and ten pediatric users of MED-EL CIs participated. The LiveECAPMAPs were compared to behavioral maps (LiveBurstMAPs) and to the participants’ everyday clinical maps (ClinMAPs). Four evaluation measures were considered: average deviations of the maximum comfortable loudness (MCL) levels of the LiveECAPMAPs and the LiveBurstMAPs from the MCLs of the ClinMAPs; correlations between the MCLs of the LiveECAPMAPs (MCLecap) and the LiveBurstMAPs (MCLburst) with the MCLs of the ClinMAPs (MCLclin); fitting durations; and speech reception thresholds (SRTs). All evaluation measures were analyzed separately in the adult and pediatric subgroups. For all evaluation measures, the deviations of the LiveECAPMAPs from the ClinMAPs were not larger than those of the LiveBurstMAPs from the ClinMAPs. The Pearson correlation between the MCLecap and the MCLclin across all channels was r2 = 0.732 (p < 0.001) in the adult and r2 = 0.616 (p < 0.001) in the pediatric subgroups. The mean fitting duration in minutes for the LiveECAPMAPs was significantly shorter than for that of the LiveBurstMAPs in both subgroups: adults took 5.70 (range 1.90–11.98) vs. 9.27 (6.83–14.72) min; children took 3.03 (1.97–4.22) vs. 7.35 (3.95–12.77). SRTs measured with the LiveECAPMAPs were non-inferior to those measured with the ClinMAPs and not statistically different to the SRTs measured with the LiveBurstMAPs. ARTFit is a safe, quick, and reliable tool for audiologists to produce ECAP-based initial fitting maps in adults and young children who are not able to provide subjective feedback.
The Potential Role of Nutrition in Lung Cancer Establishment and Progression
Authors: Porro Chiara , La Torre Maria Ester , Tartaglia Nicola , Benameur Tarek , Santini Mario , Ambrosi Antonio , Messina Giovanni , Cibelli Giuseppe , Fiorelli Alfonso , Polito Rita , Messina Gaetana
Published: February 2022

Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology.