bluuebunny/crossref_metadata_2025 huggingface dataset:
BIOLOGICAL AGE AS A METHOD FOR ESTIMATING HEALTH LEVEL UNDER ENVIRONMENTAL RISKS (LITERATURE REVIEW)
Authors: Prokhorov N. I. , Dontsov V. I. , Krutko Vyacheslav N. , Khodykina T. M.
Published: December 2019

The widespread formation of unfavorable environmental, the swiftness of modern life with large information and psycho-emotional loads and extremely natural and climatic cataclysms, as well as harmful addictions and wrong way of life of modern human, lead to the development of stress and disruption of the mechanisms of adaptation of the human body and its accelerated wear. This stimulates the development of research on the creation of new methods of integrated assessment of health and quantitative assessment of the aging processes of the body systems and the whole body, as well as the possibilities of new methods of risk assessment of climatic and environmentally related pathological and age-related diseases. The aim of the work was to consider the methodology of quantitative assessment of individual health and the rate of aging of the human body on the basis of the system index of Biological age (BA); description of its essence and structure, requirements for tests - biomarkers of aging used as the index of BA, definition of possibilities and scope of application of the BA method in modern practice of Biomedicine. The use of modern methods of scientific analysis - a systematic approach to the analysis of the processes of human aging and determine its quantitative side - the value of BA, allows a reasonable approach to the choice of the number of BM, to take into account their information content and precision, and the cost of diagnostics and availability for different users, to take into account the specific objectives of the researcher. The use of the index-partial BA allows individual approaching the choice of biomarkers and create personalized panels for the definition of BA programs for the prevention of aging in personalized preventive medicine. The complexity of the content and calculation of indices of BA requires automation and the use of methods of modern computer science and computer calculations and programs. For this purpose, we have created special computer software for diagnosing aging by calculating the BA indices with the possibility of choosing BM and automatic calculation of indicators and conclusions.
Definição da inovação no âmbito da pesquisa brasileira
Authors: Lu Yi Chieh , Matui Natália , Gracioso Luciana
Published: December 2019

Tendo em vista a necessidade das Universidades Públicas brasileiras de se localizarem e se posicionarem em relação às investidas políticas e econômicas recebidas para se converterem em lócus de produção da Inovação, se objetiva investigar, no âmbito das pesquisas científicas brasileiras, quais os entendimentos, ou ainda, quais as definições de Inovação têm sido adotadas ou construídas em diferentes áreas de conhecimento, dando destaque ao campo da Ciência da Informação (CI). Assim, são objetivos da pesquisa: analisar as definições de Inovação apresentadas nas teses e dissertações brasileiras, identificando as predominâncias sobre concepções de Inovação nestas obras acadêmicas. Para tanto, foi desenvolvida uma pesquisa descritiva e exploratória, empregando métodos de mineração textual e análise semântica por meio de software KhCoder, nos textos das teses e dissertações brasileiras sobre o tema. O recorte dos dados é essencialmente nacional, utilizando a base de dados da Biblioteca Digital de Teses e Dissertações. A partir dos dados coletados procurou-se refletir sobre as perspectivas multidisciplinares da Inovação, apresentadas em pesquisas científicas, que poderiam ser assumidas pelas Universidades Públicas para um melhor entendimento de sua vocação para a Inovação. Com os resultados obtidos, foi possível identificar a “Inovação tecnológica” como a concepção mais predominante nas pesquisas brasileiras, assim como a definição de Inovação tendente ao aspecto empresarial e suas definições subjacentes, o que condiz com a alta centralidade da área de conhecimento da Administração nos discursos de Inovação.
Desenvolvimento de coleções em coleções digitais
Authors: Oliveira Anastácia Freitas de , Cunha Murilo Bastos da
Published: December 2019

Relata as mudanças de paradigmas ocorridas na transição de coleções físicas para as coleções digitais. Apresenta as recomendações para seleção, criação e manutenção dessas coleções, a partir do exame de literatura especializada, abordando aspectos do conteúdo, viabilidade técnica, funcionalidade, confiabilidade, suporte do fornecedor, licenciamento, preservação, acessibilidade e aspectos contratuais. Discorre sobre aspectos que devem ser observados na tomada de decisão sobre a escolha de manter ou não documentos impressos quando há o equivalente digital. Conclui com a síntese das recomendações, indicando também estudos relacionados ao desenvolvimento de coleções.
Bibliometria do acervo ENANCIB (1994 a 2018)
Authors: Maia Marcelo , Tsunoda Denise Fukumi
Published: December 2019

Um dos maiores eventos de pesquisa e de pós-graduação da área de Ciência da Informação do país. Sendo assim o objetivo desse trabalho mapear a produção científica por meios de análises bibliométricas, caracterizando o Enancib a partir dos trabalhos publicados nas páginas dos eventos, compreendendo as 19 edições até o momento, absorvendo os grupos de trabalhos. O corpus de estudo foi composto de 4.282 publicações no evento, inserido e processado no software Microsoft Excel, gerando informação de frequência e número de itens publicados dos autores e coautores mais produtivos, posição de autoria dos autores mais produtivos, sendo estes separados, por edição e por grupo de trabalho. O estudo permite verificar a trajetória da existência do Encontro Nacional de Pesquisa em Ciência da Informação, quanto aos componentes: publicações, autores e coautores mais produtivos por edição, grupo de trabalho e na totalidade do evento, 24 anos. A pesquisa revelou que o fato de o autor estar no primeiro lugar, como o autor mais produtivo do evento das edições analisadas, não significa que este seja o mais produtivo por edição e também por grupo de trabalho. Também revelou, o quantitativo de autores em cada grupo de trabalho, edição, demonstrando que a área de ciência da informação está em constante crescimento.
Sentidos docentes asignados a la enseñanza de la investigación formativa en una facultad de educación
Authors:   Universidad Nacional de San Agustín de Arequipa, Turpo Gebera Osbaldo , Gonzales-Miñán Milagros ,   Universidad Antonio Ruiz de Montoya, Mango Quispe Pedro ,   Universidad Nacional de San Agustín de Arequipa, Cuadros Paz Luis ,   Universidad Nacional de San Agustín de Arequipa
Published: December 2019

En la enseñanza de la investigación formativa se suscitan una serie de construcciones subjetivas sobre su comprensión y trascendencia. Dicha situación incita a determinar los sentidos asignados a su implementación pedagógica en la formación del profesorado. En esa intención, se ha entrevistado a 20 docentes de una facultad de educación de una universidad pública del Perú, a fin de reconocer los sentidos establecidos en su concepción, su distinción de la investigación científica, sus características y expectativas. Los resultados evidencian que los docentes expresan una diversidad de sentidos formativos, más próximos a la formación de investigadores que como dispositivo o estrategia de enseñanza; asimismo, distinguen tenuemente a la investigación formativa de la investigación (cientifica) en sentido estricto, que los induce a traslapes o continuidades entre ellas; de otro lado, enfatizan en el desarrollo de capacidades cognitivas ligadas a la investigación, y finalmente, sitúan en el proceso formativo de la investigación, diversas expectativas de realización no siempre concretadas en la enseñanza. La aproximación a los sentidos asignados a la investigación formativa evidenció diferenciaciones, confusiones, pero también, coincidencias sobre el carácter formativo de la investigación, que conllevan a pensar en estrategias para un mejor afrontamiento a los desafíos docentes y de la sociedad.
Psychiatric Distress as a Common Risk Factor for Tinnitus and Joint Pain: A National Population-Based Survey
Authors: Park Euyhyun , Kim Hyunjung , Choi In Hak , Han Hye Min , Han Kyungdo , Jung Hak Hyun , Im Gi Jung
Published: December 2019

Objectives. This study aimed to investigate the relationship between tinnitus and joint pain from representative samples of Koreans.Methods. The demographics and the responses to a questionnaire about tinnitus and joint pain severity and mental health status of adults aged ≥50 years in the 2010–2012 Korean National Health and Nutrition Examination Survey were analyzed.Results. Among 9,032 individuals, 26.7% reported experiencing tinnitus within the past year. Participants with tinnitus were more frequently older, hearing loss, and had lower education levels, income, and body weight. Participants with regular exercise and sleep had a lower tinnitus prevalence. The incidences of stress, depressed mood, and suicidal ideation were significantly higher in the tinnitus group and participants with joint pain. The rates of participants with tinnitus according to the number of joint pain sites (zero, one, two, and three) was 22.1%, 31.4%, 33.3%, and 44.2%, and those of participants with severely annoying tinnitus according to the number of joint pain sites (zero, one, two, and three) were 3.3%, 6.8%, 7.9%, and 10.7%, respectively.Conclusion. Tinnitus prevalence and severity were significantly related to joint pain, and both conditions were related to psychiatric distress. Thus, the authors suggest that psychiatric distress as a common risk factor for tinnitus and joint pain should be considered when deciding treatment strategies and in guiding public health policy.
Bilateral Patellar Stress Fractures in a Skeletally Immature Athlete
Authors: Scully William F. , Rumley MAJ Jacob C. , Caskey Paul M.
Published: December 2019

Case:

This report describes the divergent course and management of bilateral patellar stress fractures in a 17-year-old skeletally immature male athlete. Beginning as bilateral incomplete tension-sided patellar fractures, the right patella healed uneventfully, whereas the left progressed to a complete, mildly displaced transverse fracture that eventually healed with nonoperative treatment measures to include temporary bracing, physical therapy, and vitamin D supplementation.

Conclusions:

Patellar stress fractures are exceptionally rare, particularly bilateral injuries in the pediatric population. Diligent workup is necessary for appropriate diagnosis, whereas knowledge of the salient features of these injuries is useful in treatment.
Lumbar Disc Herniation Within Solid Fused Segments After Removal of Pedicle Screws
Authors: Ha Kee-Yong , Kim Young-Hoon , Park Hyung-Youl , Min Hyung-Ki , Kim Sang-Il
Published: December 2019

Case:

A 73-year-old man with instrumented fusion of L3-4-5 underwent the removal of previous pedicle screws and posterior instrumented fusion of L1-2-3. The solid dorsal fusion mass of L3-5 was identified intraoperatively and preoperatively. At 3 years after the second surgery, he presented with abrupt radiating pain in the left leg. Plain radiographs showed a collapse of the intervertebral disc space, and magnetic resonance imaging showed disc herniation of L3-4.

Conclusions:

Disc herniation even in solid fused segments may occur. Removal of pedicle screws and cranial extension of interbody fusion may increase the intradiscal stress associated with physiologic cantilever motion of the disc.
Radiology of Acquired Constriction Band Syndrome: An Unusual Cast Complication
Authors: L.G. Shyamasundar , Madhuri Vrisha
Published: December 2019

Case:

A severe acquired constriction band in the proximal calf in an infant treated with a below-knee cast, which was protected with a waterproof sheet secured with a rubber band, is described. The radiological and computed tomography features of an elastic band causing the acquired constriction are presented for their novelty and uniqueness in the complication of cast treatment.

Conclusions:

The waterproof covering of plaster casts in children secured with a rubber band to prevent soiling can cause an acquired constriction band, which mimics osteomyelitis. The imaging modalities showed the elastic band shadow cutting through the bone and soft tissues as demonstrated in this case. We recommend that the complication can be prevented by avoiding the use of elastic bands to hold the waterproofing covers for the cast.
Geografía de los altares de tres focvli dedicados a Lares viales en Hispania
Authors: ABASCAL PALAZÓN JUAN MANUEL
Published: December 2019

La península Ibérica ha proporcionado hasta el momento 51 epígrafes latinos dedicados a los Lares viales, de los que 18 muestran tres foculi en el coronamiento. La ubicación de esos monumentos demuestra que este tipo de altares constituyen un fenómeno casi exclusivo del conventus Lucensis, donde aparecen también asociados a otras divinidades. Este texto presenta un catálogo de los monumentos (incluyendo dos altares inéditos) y analiza la importancia del fenómeno, para saber si se trata de una tradición religiosa o de una moda epigráfica.
Arqueologia 3.0. da escavação ao 3d. Gestão, inovação e divulgação em arqueología
Authors: García Vegas Gonzalo
Published: December 2019

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Molecular marker assisted gene stacking for disease resistance and quality genes in the dwarf mutant of an elite common wheat cultivar Xiaoyan22
Authors: zheng weijun , Li Song , Liu ZiHui , Zhou Qi , Feng Yanru , Chai ShouCheng
Published: December 2019

Development of wheat cultivars with multiple disease resistance and high quality are major objectives in modern wheat breeding programs. Gene stacking is an efficient approach to achieve this target. In this study, we pyramided yellow rust resistance gene (Yr26), powdery mildew resistance gene (ML91260) and high-molecular-weight glutenin subunits Dx5+Dy10 into the dwarf mutant of an elite wheat cultivar, Xiaoyan22. Six pyramided lines were obtained by molecular marker-assisted selection (MAS) and field evaluation of disease resistance. The desirable agronomic traits of pyramided lines, their identity with the original cultivar Xiaoyan22 except for plant height, tiller number and disease resistance, was achieved in this study. Meanwhile, the yield of pyramided lines is higher than Xiaoyan22 in the field test. In addition, analysis of flour quality indicated that the dough stability time of pyramided lines was longer than that of Xiaoyan22. These results demonstrate that it is feasible to improve multiple agronomic traits simultaneously by rational application of MAS.
Pathogenic fungi-induced susceptibility is mitigated by mutual Lactobacillus plantarum in the Drosophila melanogaster model
Authors: Su Wanzhen , Liu Jialin , Bai Peng , Ma Baocang , Liu Wei
Published: December 2019

Background Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them to flourish across the globe. Extensive studies have highlighted the significant involvement of indigenous microbial communities in human health. However, the daunting diversity of mammalian microbiota and host genetic complexity are major obstacles to our understanding of these intricate links between microbiota components, host immune genotype, and disease phenotype. In this study, we sought to develop a bacterium-fungus-Drosophilamodel to systematically evaluate the anti-fungal effects of commensal bacteria. Results We isolated the pathogenic fungal strain, Diaporthe FY, which was detrimental to the survival and development of Drosophilaupon infection. Using Drosophilaas a model system, Drosophila-associatedLactobacillus plantarumfunctioned as a probiotic, and protected the flies from mortality induced by Diaporthe FY. Our results show that L. plantarumhindered the growth of Diaporthe FY in vitro, and decreased the mortality rate of Diaporthe FY-infected flies in vivo, consequently mitigating the toxicity of Diaporthe FY to the hosts. Additionally, the presence of L. plantarumoverrode the avoidance of oviposition on Diaporthe FY-associated substrates. Conclusions Diaporthe FY was identified as a potential Drosophila pathogen. Commensal L. plantarummitigated the susceptibility of Drosophilato pathogenic fungi, providing insight into the natural interplay between commensal and pathogenic microbial communities that contribute to animal health and pathogenesis. Keywords L. plantarum, fungal infection, Drosophila, antagonist, oviposition.
Evaluation of the Safety and Tolerability of a Nutritional Formulation in Patients with Angelman Syndrome (FANS): Study Protocol for a Randomized Controlled Trial
Authors: Herber Donna L. , Weeber Edwin J. , D’Agostino Dominic P. , Duis Jessica
Published: December 2019

Background Ketogenic and low glycemic index diets are effective in treating drug resistant seizures in children with Angelman syndrome. Cognition, mobility, sleep, and gastrointestinal health are intrinsically linked to seizure activity and overall quality of life. Ketogenic and low glycemic diets restrict carbohydrate consumption and stabilize blood glucose levels. The ketogenic diet induces ketosis, a metabolic state where ketone bodies are preferentially used for fuel. The use of exogenous ketones in promoting ketosis in Angelman syndrome has not been previously studied. The study formulation evaluated herein contains the exogenous ketone beta-hydroxybutyrate to rapidly shift the body towards ketosis, resulting in enhanced metabolic efficiency. Methods This is a 16 week, randomized, double blind, placebo-controlled crossover study to assess the safety and tolerability of a nutritional formula containing exogenous ketones. It also examines the potential for exogenous ketones to improve the patient’s nutritional status which can impact the physiologic, symptomatic, and health outcomes liabilities of living with Angelman syndrome. Discussion This manuscript outlines the rationale for a study designed to be the first to provide data on nutritional approaches for patients with Angelman syndrome using exogenous ketones.
Husbands’ experience and perception of supporting their wives during childbirth in Tanzania
Authors: Kashaija Denis Kampayana , Mselle Lilian Teddy , Mkoka Dickson Ally
Published: December 2019

Background: In order improve the quality of birth care and women satisfaction with birthing process it is recommended that every woman should be offered the option to experience labour and childbirth with a companion of her choice. Involving husbands as decision makers in the household may a play role in reducing maternal mortality which is unacceptably high despite the targeted goal to reduce these mortality as targeted in the MDGs by 2015. This is still addressed in the Sustainable Development Goals (SDGs) of 2015/30. This study aimed to explore the experiences and perceptions of husbands’ support of their wives during pregnancy, labour and deliveries in Tanzania.Methods: Qualitative descriptive study design was employed; involving men aged between 24 and 63 years. Participants were selected purposefully at the clinic and in labour ward of SekouToure Regional Referral Hospital (SRRH). The in-depth interview, guided by semi structured interview guide was used to collect the audio recorded and hand written information. Data were analysed using qualitative content analysis Results; Nine (9) semi-structured interviews were conducted with husbands of women attended for antenatal care and those came for deliveries. Four themes emerged; Demonstrating care, love and affection, adopting modern life style, observing women’s right and meeting social economic difficulties. Husbands’ support to their partners is a good behaviour practiced during matrimonial lives. Husbands who support their partners during pregnancy and delivery consider themselves as being modern men as they at home take duties beside their usual tasks to let their wives have adequate time to rest during pregnancy. Poor road infrastructure makes difficult to get transport to the healthcare facility especially when labour is imminent. Also ward infrastructure is not supportive to accommodate husbands when they accompany their wives to the healthcare facility. Conclusions; The healthcare settings in low income countries need to accommodate men during the routine antenatal and intranatal care for the positive outcome of labour and delivery. Exploratory research should be conducted to understand how education and urbanisation affects men involvement in maternal and child health specifically in the low income countries.
A pilot study: A possible implication of Candida as an etiologically endogenous pathogen for oral lichen planus
Authors: He Hong , Xia Xinyu , Yang Haiping , Peng Qiao , Zheng Jiaoer
Published: December 2019

Background: The aim of this study was to investigate the prevalence and genotypic profiles of Candida albicans in patients with oral lichen planus (OLP). Materials and Methods:Positive rates and genotypic profiles of Candida albicansstrains from OLP patients and healthy controls were analyzed. Random amplified polymorphic DNA and internal transcribed spacer of ribosome DNApolymerase chain reactions were used to sequence the DNA of these strains, and then their geneticsimilarity was measured using BLAST, UIV Band, and Vector NTI Suite Sequence AnalysesSoftware. Results:The prevalence of C. albicansstrains detected from erosive-OLP, non-erosive OLP, and normal individuals was 18.87%, 18.75%, and 7.92%, respectively. Four different genotypes were revealed by the two methods. To be specific, type I was found only in the healthy subjects; type II a and II b were found in non-erosive OLP, and type III was identified in erosive OLP. Intragroup similarity coefficients, i.e. SABwere 100%, and inter-groups similarity coefficients, i.e. SABwere less than 30%. Conclusions:The genotypic results of C. albicansin OLP revealed an endogenous rather than exogenous infection of C. albicans. In addition, a possible pathogenic role of C. albicansin OLP, with the etiologic sense contributing to a more proper recognition on the pathogenesis, development, and progression of OLP, as well as some strategies for its diagnosis and treatment were identified.
Epidemiological analysis of the Kaohsiung city strategy for dengue fever quarantine and epidemic prevention
Authors: CHEN Chun-Hong , Pan Chao Ying , Liu Wei-Liang , Su Matthew P. , Chang Te Pin , Ho Hui-Pin , Huang Joh-Jong , Lin Li Jen , Shu Pei-Yun
Published: December 2019

Background. Dengue is endemic in over 100 countries and is an important public health problem worldwide. Dengue is not considered endemic in Taiwan however, with importation of dengue viruses from neighboring countries via close commercial links and air travel believed to be the cause of local outbreaks. Disease control efforts have therefore focused on preventing the importation of dengue into Taiwan. Here, we investigate the relationships between numbers of imported and indigenous dengue cases to test the validity of this strategy. Methods. Dengue-fever case data from between 2013 and 2018 was obtained from the surveillance systems of the Taiwan Center for Disease Control and Kaohsiung City Health department. Standard epidemiological data, including the monthly numbers of indigenous and imported dengue cases, was calculated. Potential associations between the number of indigenous and imported cases were investigated using correlation analyses. Results. We identified a possible relationship between the period of disease concealment and the number of reported imported dengue cases which resulted in indigenous dengue-fever epidemics within local communities. Further analysis of confirmed dengue cases during previous dengue-fever epidemics in Kaohsiung City found that the risk of indigenous dengue-fever may be related to the likelihood of patients suffering from imported cases of dengue-fever staying within local communities. Conclusion. Given the correlations found between imported and indigenous dengue-fever cases, as well as the relationship between disease concealment period and risk of indigenous dengue-fever, the major priorities for disease control remain prevention of disease importation and efficient identification of dengue cases within high-risk communities.
Repeat Induced Abortion And Associated Factors Among Women Seeking Abortion Care Services At Debre Markos Town Health Institutions, Amhara Regional State, Ethiopia, 2017.
Authors: Waktola Mahlet Imana , Mekonen Dawit Gebeyehu , Nigussie Tewodros Seyoum , Cherkose Endeshaw Adimasu , Abate Addisu Taye
Published: December 2019

Objective the aim of this study was to assess the proportion and determinants of repeat induced abortion among women seeking abortion care services at Debremarkos town health institutions, Amhara regional state, Ethiopia, 2017.Result from the total 567-sample size, 547 women were participated in the study making a response rate of 96.5%. In this study 191 woman reported that they had at least one previous abortion, making the proportion of repeat induced abortion 34.9%. In multivariable logistic regression analysis; illiteracy (AOR=8.45, 95%CI; 1.85, 36.49), living in an urban area (AOR=5.14, 95%CI; 2.29, 11.53), having multiple sexual partner (AOR=6.16, 95%CI; 3.25, 11.68), consuming alcohol (AOR=2.77, 95%CI; 1.52, 5.05) and having a history of physical violence by a male partner (AOR=2.68, 95%CI; 1.45, 4.94) were significantly associated with repeat induced abortion at p value less than 0.05.
Transcriptomic study of pedicels from GA3-treated table grape genotypes with different susceptibility to berry drop reveals responses elicited in cell wall yield, primary growth and phenylpropanoids synthesis.
Authors: Meneses Marco , García-Rojas Miguel , Muñoz-Espinoza Claudia , Carrasco-Valenzuela Tomás , Defilippi Bruno , González-Agüero Mauricio , Meneses Claudio , Infante Rodrigo , Hinrichsen Patricio
Published: December 2019

Background Gibberellins (GA3) are the most sprayed growth regulator for table grape production worldwide, increasing berry size of seedless varieties through pericarp cell expansion. However, these treatments also exacerbate berry drop, which has a detrimental effect on the postharvest quality of commercialized clusters. Several studies have suggested that pedicel stiffening caused by GA3 would have a role in this disorder. Nevertheless, transcriptional and phenotypic information regarding pedicel responses to GA3 is minimal.Results Characterization of responses to GA3 treatments using the lines L23 and Thompson Seedless showed that the former was up to six times more susceptible to berry drop than the latter. GA3 also increased the diameter and dry matter percentage of the pedicel on both genotypes. Induction of lignin biosynthesis-related genes by GA3 has been reported, so the quantity of this polymer was measured. The acetyl bromide method detected a decreased concentration of lignin seven days after GA3 treatment, due to a higher cell wall yield of the isolated fractions of GA3-treated pedicel samples which caused a dilution effect. Thus, an initial enrichment of primary cell wall components in response to GA3 was suggested, particularly in the L23 background. A transcriptomic profiling was performed to identify which genes were associated with these phenotypic changes. This analysis identified 1,281 and 1,787 genes differentially upregulated by GA3 in L23 and cv. Thompson Seedless, respectively. Concomitantly, 1,202 and 1,317 downregulated genes were detected in L23 and cv. Thompson Seedless (FDR≤0.05). Gene ontology analysis of upregulated genes showed enrichment in pathways including phenylpropanoids, cell wall metabolism, xylem development, photosynthesis and the cell cycle at seven days post GA3 application. Twelve genes were characterized by qPCR and striking differences were observed between genotypes, mainly in genes related to cell wall synthesis.Conclusions High levels of berry drop are related to an early strong response of primary cell wall synthesis in the pedicel promoted by GA3 treatment. Genetic backgrounds can produce similar phenotypic responses to GA3, although there is considerable variation in the regulation of genes in terms of which are expressed, and the extent of transcript levels achieved within the same time frame.
Clinical and microbiological effect of pulsed xenon ultraviolet disinfection to reduce multidrug-resistant organisms in the intensive care unit in a Japanese hospital: a before-after study
Authors: Morikane Keita , Suzuki Shoko , Yoshioka Jun , Yakuwa Jun , Nakane Masaki , Nemoto Kenji
Published: December 2019

Background No-touch environmental disinfection using ultraviolet devices has been highlighted in the past several years to control the transmission of multidrug-resistant organisms (MDROs). However, its effectiveness in non-US healthcare settings is yet to be examined. This study aimed to evaluate the effectiveness of disinfection by portable pulsed xenon ultraviolet (PX-UV) devices in controlling transmission of MDROs in a non-US healthcare setting. Methods All patients admitted in the intensive care unit in a 629-bed tertiary referral hospital in Japan from August 2016 to February 2019 were enrolled. During the study period, PX-UV disinfection was added to manual terminal cleaning after every patient transfer/discharge. For microbiological evaluation, surfaces were selected for sampling by contact plates before/after manual cleaning and after PX-UV. After overnight incubation, colonies on the plates were counted. Results The incidence of newly acquired methicillin-resistant Staphylococcus aureus (MRSA) declined significantly (13.8 to 9.9 per 10,000 patient days, incidence rate ratio 0.71, p=0.002), as well as that of newly acquired drug-resistant Acinetobacter (48.5 to 18.1, 0.37, p<0.001). The percent reduction of the microbiological burden by manual cleaning was 81%, but a further 59% reduction was achieved by PX-UV. Conclusions PX-UV is effective in further reducing the microbial burden and controlling MDROs in a non-US healthcare setting.
High Dose and Low Dose Oxytocin Regimens as Determinants of Successful Labor Induction: A multicenter comparative study
Authors: TESEMMA MELESE GEZAHEGN , Sori Demisew Amenu , Gemeda Desta Hiko
Published: December 2019

Background: Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of induction. Methods: Hospital-based comparative cross-sectional study was conducted in four selected hospitals in Ethiopia from October 1, 2017 to May 30, 2018. A total of 216 pregnant women who undergo induction of labor at gestational age of 37 weeks and above were included. Data were entered into Epi-data version 3.1 and then exported to SPSS version 20 for cleaning and analysis. Chi-square test and logistic regression were done to look for determinants of successful induction. The result was presented using 95% confidence interval of crude and adjusted odds ratios. P-value < 0.05 was used to declare statistical significance. Result: The mean “Induction to delivery time” was 5.9 hours and 6.3 hours for participants who received high dose Oxytocin and low dose Oxytocin respectively. Higher successful induction (72.2% versus 61.1%) and lower Cesarean Section rate (27.8% vs. 38.9) were observed among participants who received low dose Oxytocin compared to high dose. Favourable bishop score [AOR 4.0 95% CI 1.9, 8.5], elective induction [AOR 0.2 95% CI 0.1, 0.4], performing artificial rupture of membrane [AOR 10.1 95% CI 3.2, 32.2], neonatal birth weight of < 4Kg [AOR 4.3, 95% CI 1.6, 11.6] and being parous [AOR 2.1 95% CI 1.1, 4.0] were significantly associated with success of induction. Conclusions: In this study, Different oxytocin regimens didn’t show significant association with success of induction. But, high dose oxytocin regimen was significantly associated with slightly shorter induction to delivery time. Favourable bishop score, emergency induction, performing artificial rupture of membrane and delivery to non-macrosomic fetuses were positive determinants of successful induction.We recommend researchers to conduct multicenter research on a large number of patients that controls confounders to see the real effects of different oxytocin regimens on success of labor induction.
Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA
Authors: Liu Juejun , Chen Changzheng , Li Lu , Xu Yishuang , Yi Zuohuizi , He Lu , Zheng Hongmei
Published: December 2019

Background: To quantify flow changes in choriocapillaris (CC) in patients with chronic central serous chorioretinopathy (CCSC) in the treatment of half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA).Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. Proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA were mainly assessments in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA. Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up than 1-m follow-up (p=0.036). Comparing to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT can be identified, including signs of recovery with more even flow signals, transient appearance of worsen ischemia and secondary neovascularization within CC level. Conclusion: Abnormal CC flow attenuation remained in completely resolved eyes of CCSC patients treated with half-dose PDT. Key Words: Chronic; Central Serous Chorioretinopathy; Optical Coherence Tomography Angiography; Photodynamic Therapy
Anti-rheumatic treatment and prosthetic joint infection: An observational study in 494 elective hip and knee arthroplasties.
Authors: Borgas Ylva , Gülfe Anders , Kindt Mikael , Stefánsdóttir Anna
Published: December 2019

Background Surgical site infections are more frequent among patients with rheumatic disease. To which extent this is related to immunosuppressive antirheumatic drugs is unclear, as is the value of discontinuing medication perioperatively.Objectives To assess the rate of surgical site infections after knee and hip-replacement in patients with inflammatory joint disease, with emphasis on periprosthetic joint infection, and to investigate the importance of medical treatment in this regard.Methods Data was collected from 494 primary elective hip- (51.4%) and knee arthroplasties along with demographic and medication data and primary outcome was surgical site infections during the first year after surgery.Results In 78% (n=385) of the cases the patient medicated with 1 to 3 disease-modifying antirheumatic drugs perioperatively. Thirty two per cent (n=157) of patients were on a TNF-alpha inhibitor perioperatively. The rate of surgical site infections was 3.8% (n=19) The rate of periprosthetic joint infection was 1.4% (n=7), all of which were knee arthroplasties. Only in 1 case of periprosthetic joint infection the patient medicated perioperatively with a TNF-alpha inhibitor.Conclusion Surgical site infections was not associated with ongoing medication with disease-modifying antirheumatic drugs. Due to low event rate this should be interpreted with caution. Routines at our centre, not stopping biologic disease-modifying antirheumatic drugs perioperatively, will be unchanged.
Low cyclosporine concentrations in children and time to acute graft versus host disease
Authors: Chung Eun Kyung , Yee Jeong , Kim Jae Youn , Gwak Hye sun
Published: December 2019

Background Achievement of target blood concentrations of cyclosporine (CsA) early after transplantation is known to be highly effective for reducing the incidence of acute graft versus host disease (aGVHD). However, no research has been conducted for predicting elapsed time from low CsA concentration to aGVHD occurrence. The objective of this study was to investigate the risk of aGVHD according to elapsed time from low CsA concentrations in children with allogenic hematopoietic stem cell transplantation (HSCT). Methods The outcomes of 61 consecutive children who underwent allogeneic HSCT and received CsA as prophylaxis against aGVHD between May 2012 and March 2015 were retrospectively evaluated; the main outcome was any association between elapsed time from low CsA concentrations to aGVHD occurrence. Elapsed time was defined as follows: one week (0–6 days), two weeks (7–13 days), or three weeks (14–20 days), and the incidence of aGVHD was examined for the first three months after transplantation. ResultsIn children whose mean CsA concentration after the allogenic HSCT did not reach the initial target concentration, the adjusted odds ratio for developing aGVHD within one week was 12.3 (95% confidence interval [CI]: 2.7–56.0). The AORs for developing aGVHD between 7 and 13 days and between 14–20 days were 90.8 (95% CI: 8.3–999.9) and 28.1 (95% CI: 2.4–333.1), respectively. Conclusions Careful attention needs to be paid to the elapsed time after low CsA concentrations are detected to prevent aGVHD.
Effects of chalazion and its treatments on the meibomian glands: non-randomized, prospective observation clinical study
Authors: Li Junping , Li Dongping , Zhou Na , Qi Mengying , Luo Yanzhu , Wang Yuhong
Published: December 2019

Background To observe the effects of chalazion and its treatments on the meibomian gland function and morphology in chalazion area. Methods This non-randomized, prospective observation clinical study included 58 patients (67 eyelids) cured of chalazion, including 23 patients (23 eyelids) treated with conservative method, and 35 patients (44 eyelids) with surgery. Slit lamp microscopy, infrared meibomian gland photography and in vivo laser scanning confocal microscopy (LSCM) were performed before treatment and 1 month after the chalazion complete resolution. The meibomian gland function, the area proportion and acinar structure in the chalazion area were analyzed before and 1 month after the chalazion resolution.Results In patients with conservative treatment, the meibomian gland function parameters improved at 1 month after chalazion resolution compared to those before treatment (P<0.05). There was no significant statistical difference in meibomian gland functional parameters before and after surgery (P>0.05). According to infrared meibomian gland photography, after chalazion resolution, the area presented meibomian gland loss, there was no significant statistical difference between the proportion of meibomian gland loss at 1 month after chalazion resolution and the proportion of the initial chalazion area (P>0.05) regardless of the treatment strategy. The acinar structure could not be observed clearly after the chalazion complete resolution. Conclusions Chalazion will cause meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method, but the range of the chalazion itself. Hot compress in conservative treatment can improve the meibomian gland function that chalazion located in short term.
Quality of Life and its Related Factors in Iranian Addicted Women Referring to Substance Abuse Treatment Centers
Authors: Barati Majid , Bandehelahi Khadijeh , Nopasandasil Tahereh , Jormand Hanieh , Keshavarzi Amir
Published: December 2019

Background: Drug addiction is one of the most common social problems that is caused by the illegal use of addictive drugs; it affects the quality of life of substance users. Therefore, this study aimed at determine the quality of life and its related factors among addicted women referring to substance abuse treatment centers in Hamadan, west of Iran. Methods: This cross-sectional study was carried out on 120 Iranian female substance users recruited through census sampling method in 2018. Data collection tools consisted of demographic characteristics and quality of life questionnaire (SF-36). Data were analyzed using SPSS-16 via one way ANOVA and chi-square tests. Results: The mean age of the participants was 33.2 ± 12.1 years. The last drug used by the participants was methamphetamine (53.3%), methadone (20.8%), and heroin (12.5%), respectively. The mean score of total quality of life was 35.35 ± 13.5 that indicated unsatisfactory level. Moreover, there was a significant association between quality of life and age, educational level, place of residence, and job status (P<0.05). Conclusion: According to the results, the quality of life of the participants was found to be at unsatisfactory level. The identification of more vulnerable groups may increase the effectiveness of intervention programs.
The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: A pilot study
Authors: Zhang Bin , Xu Ting , Yin Daqiang , Wei Sheng
Published: December 2019

Background Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies on the health effects and toxicity of BDE-209 focused on thyroid disruption, oxidative stress, neurotoxicity and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209.Results BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf) larvae, however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concertation exposures.Conclusion The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.
Validation of the Spanish version of Migraine Disability Assessment questionnaire (MIDAS) in migraine university students.
Authors: Rodríguez-Almagro Daniel , Achalandabaso Alexander , Rus Alma , Obrero-Gaitán Esteban , Zagalaz-Anula Noelia , Lomas-Vega Rafael
Published: December 2019

Background. The Migraine Disability Assessment (MIDAS) questionnaire is widely used for determining headache-related disability. However, to the best of our knowledge, there is no validated Spanish version of the questionnaire. It is composed of seven items; the first five items constitute the main scale, while the sixth and seventh items refer respectively to the frequency and intensity of headache. The present study is aimed at analyzing the clinimetric properties of the Spanish version of the MIDAS questionnaire in a population of university students.Methods. We performed a cross-sectional study of validation of measuring instruments. One hundred fifty-three subjects participated in the study. We analyzed construct validity by factor analysis, test-retest reliability by the Intraclass Correlation Coeficient (ICC), internal consistency, and concurrent validity with respect to the 12-Item Short Form Health Survey (SF-12).Results. Factor analysis showed a two factors structure composed. The questionnaire presented good reliability for the MIDAS-main scale score ([ICC = 0.81; 95% CI: 0.63 – 0.90]), excellent reliability for headache frequency (ICC = 0.90; 95%; CI: [0.79 – 0.95]), and moderate reliability for headache intensity (ICC = 0.63; 95% CI: [0.34 – 0.80]). The analysis also showed good internal consistency results (α Cronbach = 0.797) and a moderate correlation between MIDAS-main scale and physical summary component of SF-12 (Rho = -0.326; p < 0.001).Conclusions. The Spanish version of the MIDAS questionnaire is a valid and reliable tool to measure headache-related disability in university subjects. The two additional items provide information that could help clinicians in making decisions.
Implementation of the WHO Hand Hygiene Strategy in Faranah Regional Hospital, Guinea
Authors: Müller Sophie Alice , Diallo Alpha Oumar Karim , Wood Rebekah , Bayo Mouctar , Eckmanns Tim , Tounkara Ousmane , Arvand Mardjan , Diallo Mamadou , Borchert Matthias
Published: December 2019

Background: Healthcare-associated infections are the most frequent adverse events in healthcare worldwide, with limited available evidence suggesting highest burden in resource-limited settings. Recent Ebola epidemics emphasize the disastrous impact that spread of infectious agents within healthcare facilities can have, accentuating the need for improvement of infection control practices. Hand hygiene (HH) measures are considered to be the most effective tool to prevent Healthcare-associated infections. However, HH knowledge and compliance are low, especially in vulnerable settings such as Guinea. The aim of PASQUALE (Partnership to Improve Patient Safety and Quality of Care) was to assess knowledge and compliance with HH and improve HH by incorporating the WHO HH Strategy within the Faranah Regional Hospital (FRH), Guinea.Methods: In a participatory approach, a team of HRF staff and leadership was invited to identify priorities of the hospital prior to the start of PASQUALE. The local hygiene committee was empowered to increase its activities and take ownership of the HH improvement strategy. A baseline assessment of knowledge, perception and compliance was performed months before the intervention. The main intervention consisted of local alcohol-based-hand-rub (ABHR) production, with final product efficacy testing, in conjunction with a training adapted to the needs identified in the baseline assessment. A follow-up assessment was conducted directly after the training. Effectiveness of the intervention was assessed via uncontrolled before-and-after comparison.Results: Baseline knowledge score (13.0/25) showed a significant increase to 19.0/25 in follow-up. Baseline-Compliance was 23.7% and increased significantly to 71.5% in follow-up. Compliance rose significantly across all professional groups except for midwifes and in all indications for HH, with the largest in the indication “Before aseptic tasks”. The increase in compliance was associated with the intervention and remained significant after adjusting for confounders. The local pharmacy successfully supplies the entire hospital. The local supply resulted in a ten-fold increase of monthly hospital disinfectant consumption.Conclusion: The WHO HH strategy is an adaptable and effective method to improve HH knowledge and compliance in a resource-limited setting. Local production is a feasible method for providing self-sufficient supply of ABHR to regional hospitals like the FRH. Participatory approaches like hygiene committee ownership builds confidence of sustainability.