bluuebunny/crossref_metadata_2025 huggingface dataset:
There and gone again? Migration to and posting of third-country nationals from Slovenia and Poland
Authors: Danaj Sonila , Vah Jevšnik Mojca , Kiełbasa Marcin , Szaraniec Monika
Published: March 2023

Drawing on research conducted in the framework of the POSTING.STAT project for Slovenia and Poland, this article contributes to the literature on the posting of third-country nationals (TCNs) within the European Union from the perspective of the sending countries. Our research questions are: What are the current posting trends and patterns of mobility of TCNs from Poland and Slovenia? How do national legal and policy instruments in Poland and Slovenia shape the recruitment of TCNs and facilitate the posting of these TCNs to other Member States? We find that the recent growth in posting from both countries is driven by the substantial increase in the number of posted TCNs, which might signal at least their complementary role, if not the replacement, of posted nationals with TCNs to sustain the established business models of posting from Slovenia and Poland. We observe two trends. Firstly, national legal and policy instruments encourage labour migration from certain third countries with which Slovenia and Poland have historical ties and geographical proximity, which are then embedded in their national labour markets. Secondly, both countries remain source countries for the posting of workers, a pattern they have been able to sustain by increasing the use of TCNs for posting. Hence, despite a growing share of TCNs involved in posting, most TCNs continue to be based in Slovenia and Poland, suggesting posting or onward migration are not necessarily the main reason these workers go to Slovenia and Poland in the first place. Yet, the increase in numbers of posted TCNs observed in both countries, regardless of stricter regulations and the Covid-19 pandemic, suggests that posting in labour-intensive sectors such as road freight transport and construction is increasingly becoming a segmented labour market. We argue that the posting of TCNs might grow into an important intra-EU mobility channel, with the caveat that while certain EU countries will insist on restricting direct access to their national labour market for TCNs, other EU countries, especially those that so far have acted as labour or services suppliers, will lend themselves as gate-openers for the intra-EU mobility of TCNs.
Crossmodal correspondences and interactions between texture and taste perception
Authors: Pistolas Eleftheria , Wagemans Johan
Published: March 2023

In recent years, awareness of the influence of different modalities on taste perception has grown. Although previous research in crossmodal taste perception has touched upon the bipolar distinction between softness/smoothness and roughness/angularity, ambiguity largely remains surrounding other crossmodal correspondences between taste and other specific textures we regularly use to describe our food, such as crispy or crunchy. Sweetness has previously been found to be associated with soft textures but our current understanding does not exceed the basic distinction made between roughness and smoothness. Specifically, the role of texture in taste perception remains relatively understudied. The current study consisted of two parts. First, because of the lack of clarity concerning specific associations between basic tastes and textures, an online questionnaire served to assess whether consistent associations between texture words and taste words exist and how these arise intuitively. The second part consisted of a taste experiment with factorial combinations of four tastes and four textures. The results of the questionnaire study showed that consistent associations are made between soft and sweet and between crispy and salty at the conceptual level. The results of the taste experiment largely showed evidence in support of these findings at the perceptual level. In addition, the experiment allowed for a closer look into the complexity found regarding the association between sour and crunchy, and bitter and sandy.
The evolution of dialysis access surgery over 38 years: One surgeon’s perspective
Authors: Hill Stephen l
Published: March 2023

Objectives:

The surgery for dialysis access has changed over the past 38 years. In the 1980s and 1990s, prosthetic grafts were the most common form of access. Then, autogenous fistulae had a rebirth due to their durability and decreased complications. The continued expansion of the dialysis population, coupled with the paucity of adequate superficial veins in many patients, required other techniques of dialysis access such as tunneled dialysis catheters, and more complex surgery on deeper veins.

Methods:

This study of one surgeon’s practice over 38 years mirrors the extensive changes in dialysis access. The changes in surgical technique, interventional procedures, and approaches were documented and evaluated.

Results:

During the 38-year period, there were 1531 autogenous fistulae, 409 prosthetic grafts, and 1624 tunneled dialysis catheters placed for access. The first 20 years had 130 autogenous fistulae with 302 prosthetic grafts, while in the last 10 years there were 740 fistulae and only 17 prosthetic grafts. Prosthetic grafts were not salvageable for a long term with exposure, infection, and persistent bleeding. Autogenous fistulae were best salvaged with autogenous tissue rather than prosthetic material. Interventional procedures were most valuable in stenting high-grade stenosis centrally and dilating areas of recurrent stenosis. They were not helpful in treatment of large aneurysms or as a long-term solution for persistent and/or massive bleeding.

Conclusion:

Dialysis access has progressed back to autogenous fistula. This may require longer use of tunneled dialysis catheters, and more surgical procedures, but the construction of an autogenous fistula can be achieved in many dialysis patients.
Imiquimod-induced bullous pemphigoid: A case report
Authors: Li Heidi Oi-Yee , Aw Michael , Glassman Steven J
Published: March 2023

A 72-year-old man treated with 3.5% imiquimod cream for scalp actinic keratoses developed the usual crusted and erosive reaction but developed bullae on the scalp, as well as the limbs and torso after several weeks into treatment. Biopsy confirmed bullous pemphigoid. He was treated with clobetasol ointment, prednisone and methotrexate, with eventual disease control. He had a severe disease course. Bullous pemphigoid is usually idiopathic, but can be induced by skin trauma, as well as by several medications; this is the first report of imiquimod as a trigger. Imiquimod is a toll-like receptor 7 agonist that induces cellular apoptosis and recruits pro-inflammatory cytokines including tumour necrosis factor-alpha and interferon-alpha, which have been implicated in autoimmunity. This case highlights an unusual but severe adverse effect from topical imiquimod.
Machine learning, meaning making: On reading computer science texts
Authors: Amoore Louise , Campolo Alexander , Jacobsen Benjamin , Rella Ludovico
Published: March 2023

Computer science tends to foreclose the reading of its texts by social science and humanities scholars – via code and scale, mathematics, black box opacities, secret or proprietary models. Yet, when computer science papers are read in order to better understand what machine learning means for societies, a form of reading is brought to bear that is not primarily about excavating the hidden meaning of a text or exposing underlying truths about science. Not strictly reading to make sense or to discern definitive meaning of computer science texts, reading is an engagement with the sense-making and meaning-making that takes place. We propose a strategy for reading computer science that is attentive to the act of reading itself, that stays close to the difficulty involved in all forms of reading, and that works with the text as already properly belonging to the ethico-politics that this difficulty engenders. Addressing a series of three “reading problems” – genre, readability, and meaning – we discuss machine learning textbooks and papers as sites where today's algorithmic models are actively giving accounts of their paradigmatic worldview. Much more than matters of technical definition or proof of concept, texts are sites where concepts are forged and contested. In our times, when the political application of AI and machine learning is so commonly geared to settle or predict difficult societal problems in advance, a reading strategy must open the gaps and difficulties of that which cannot be settled or resolved.
High Rates of Satisfaction and Return to Dance in Current or Former Professional Ballet Dancers After Total Hip Arthroplasty With a Muscle-Sparing Direct Anterior Approach Using Custom Femoral Stems
Authors: Nogier Alexis , Tourabaly Idriss , Ramos-Pascual Sonia , Saffarini Mo , Baraduc Elodie , Barreau Xavière , Courtin Cyril
Published: March 2023

Background:

Professional ballet dancers have high expectations after total hip arthroplasty (THA), particularly if they intend to resume dancing as performers or teachers.

Purpose:

To report clinical outcomes and return to dance after THA with a muscle-sparing direct anterior approach using a custom femoral stem in a cohort of current or former professional ballet dancers.

Study Design:

Case series; Level of evidence, 4.

Methods:

Twenty-three patients (26 hips) were included, that identified as current or former professional ballet dancers, from a consecutive series of 1699 hips that underwent primary THA by 1 of 2 surgeons. Both surgeons routinely implanted custom femoral stems using a muscle-sparing direct anterior approach in active and/or high-demand patients. All patients completed a questionnaire postoperatively that assessed dance capabilities, the visual analog scale (VAS) for hip pain (0-10), the VAS for satisfaction with surgery (0-10), the Oxford Hip Score (OHS), and the Forgotten Joint Score (FJS).

Results:

The initial cohort comprised 19 women and 4 men, with a mean age of 50.5 ± 14.9 years and a mean 38.0 ± 14.4 years of dance experience. One patient underwent revision THA for a leg-length discrepancy, leaving 22 patients (25 hips) with a mean follow-up of 3.4 ± 1.4 years. The mean VAS satisfaction score was 9.8 ± 0.6, and the mean VAS pain score was 0.5 ± 1.0. The postoperative OHS and FJS were 46 ± 2 and 92 ± 15, respectively. Overall, 16 patients resumed ballet at 5.1 ± 3.9 months, 3 resumed other types of dance, and 3 did not resume any type of dance. None of the 6 patients who did not resume ballet indicated pain in the operated hip as the reason for stopping.

Conclusion:

In current or former professional ballet dancers, THA by a muscle-sparing direct anterior approach using a custom femoral stem yielded excellent clinical outcomes at a minimum of 2 years, with the highest satisfaction score of 10 points reported for 88% of hips and 72% of hips being totally pain free. Furthermore, 73% of patients resumed ballet, and 86% resumed dance in general.
Building on the Competency Pivot: Helping Students Build Job Portfolios for Employment
Authors: Marino Matt
Published: March 2023

The purpose of this article is to share teaching strategies within business and professional communication that assisted students in developing a job portfolio, potentially enhancing students’ ability to secure an internship or job after course completion. This article details the application of these strategies over the course of three semesters in 2018 and 2019 at Monmouth University. Student comments suggested these strategies enhanced their chances of employment success. Using course curriculum to put students in position to secure employment should be a goal of the course and curriculum should be adjusted periodically to meet this goal.
The Informal Safety Net: Social Network Activation among Hispanic Immigrants During COVID-19
Authors: Smith Nicholas C. , Brooks Caroline V. , Ekl Emily A. , García Melissa J. , Ambriz Denise , Maupomé Gerardo , Perry Brea L.
Published: March 2023

During times of crisis, individuals may activate members of their social networks to fulfill critical support functions. However, factors that may facilitate or inhibit successful network activation are not fully understood, particularly for structurally marginalized populations. This study examines predictors of network activation among recent and established Hispanic immigrants during the COVID-19 pandemic. Specifically, using unique, longitudinal data from the VidaSana study and its supplemental survey, the COVID-19 Rapid Response study ( N = 400), we ask: How are COVID-related stressors associated with goal-oriented network activation (e.g., health-focused activation) among Hispanic immigrants? How might structural and compositional characteristics of social networks facilitate or inhibit successful network activation during COVID-19? Results align with theories of network activation (i.e., functional specificity) that imply that individuals engage in selective and deliberate activation of networks. That is, we observe a congruency between COVID-related stressors and social network characteristics, and distinct types of network activation. Moreover, we find that respondents experiencing pandemic-induced economic difficulties engage in activation for financial assistance only if they are embedded in a higher-educated network. We discuss the implications of these findings and provide recommendations for future research.
Rhythm and possibility: Making space for ancient futures
Authors: Meyer Caspar
Published: March 2023

This essay explores some of the ways in which archeology and possibility studies can enrich each other’s understanding of time, agency and materiality in human behavior. It discusses the implications of linear conceptions of time for our perception of human pasts and futures, and argues for the adoption of rhythm as an alternative mode of inquiry that is capable of liberating the past from our hindsight and making space for the possible as a generative dimension of cultural practice.
Baseline PET radiomics outperform the IPI risk score for prediction of outcome in diffuse large B-cell lymphoma
Authors: Eertink Jakoba Johanna , Zwezerijnen Gerben JC , Heymans Martijn , Pieplenbosch Simone , Wiegers Sanne Elisabeth , Dührsen Ulrich , Hüttmann Andreas , Kurch Lars , Hanoun Christine , Lugtenburg Pieternella J. , Barrington Sally , Mikhaeel N. George , Ceriani Luca , Zucca Emanuele , Czibor Sandor , Györke Tamás , Chamuleau Martine E.D. , Hoekstra Otto S , De Vet Henrica CW , Boellaard Ronald , Zijlstra Josée M.
Published: March 2023

The objective of this study was to externally validate the clinicalPET model developed in the HOVON-84 trial and to compare the model performance of our clinicalPET model to the international prognostic index (IPI). In total, 1195 Diffuse large B-cell lymphoma patients were included. 887 patients from 6 studies were used as external validation datasets. Primary outcomes were 2-year progression free survival (PFS) and 2-year time to progression (TTP). Metabolic tumor volume (MTV), the maximum distance between the largest lesion and another lesion (Dmaxbulk) and the peak standardized uptake value (SUVpeak) were extracted. The predictive value of the IPI and the HOVON-84 clinicalPET model (MTV, Dmaxbulk, SUVpeak, performance status and age) were tested. Model performance was assessed using the area under the curve (AUC), and diagnostic performance with the positive predictive value (PPV). Using 2-year PFS as outcome, the IPI yielded an AUC of 0.62 (range:0.51-0.65). The clinicalPET model yielded a significantly higher AUC of 0.71 (range:0.59-0.75, p<0.001). Comparable results were found using 2-year TTP. High-risk IPI patients had a 2-year PFS of 61.4%, versus 51.9% for the high-risk clinicalPET patients, with an increase in PPV from 35.5% to 49.1%, respectively. 66.4% of high-risk IPI patients were free from progression or relapse versus 55.5% for high-risk clinicalPET patients, with an increased PPV from 33.7% to 44.6%, respectively. The clinicalPET model that was developed in the HOVON-84 dataset remained predictive of outcome in 6 independent first-line DLBCL studies, and had higher model performance than the currently used IPI in all studies.
Systematic analysis of levels of evidence supporting American Academy of Ophthalmology Preferred Practice Pattern guidelines, 2012–2021
Authors: Song Ailin , Lusk Jay B. , Kuo Anthony N. , Muir Kelly W. , Stinnett Sandra S. , Borkar Durga S.
Published: March 2023

Background

Despite the increased emphasis on evidence-based medicine, the current state of evidence behind ophthalmology clinical practice guidelines is unknown. The purpose of this systematic analysis was to understand the levels of evidence (LOE) supporting American Academy of Ophthalmology (AAO) Preferred Practice Pattern (PPP) guidelines, assess changes over time, and compare LOE across ophthalmology subspecialties.

Methods

All current PPP guidelines and their immediate predecessors were comprehensively reviewed to identify all recommendations with LOE provided (I [randomized controlled trials], II [case–control or cohort studies], and III [nonanalytic studies]).

Results

Twenty-three out of 24 current PPPs had a prior edition. Among the PPPs with a prior edition, the number of recommendations with LOE decreased from 1254 in prior PPPs to 94 in current PPPs. The number of recommendations with LOE I decreased from 114 to 83, LOE II decreased from 147 to 2, and LOE III decreased from 993 to 9. However, the proportion of LOE I recommendations increased from 9 to 88%, driven by a disproportionate decrease in reporting of evidence lower than LOE I. Subgroup analysis by subspecialty showed similar trends (LOE I recommendations in prior PPPs vs current PPPs: retina: 57 [12%] vs 19 [100%]; cornea: 33 [5%] vs 24 [100%]; glaucoma: 9 [23%] vs 17 [100%]; cataract: 13 [17%] vs 18 [100%]).

Conclusions

Trends in LOE reporting in PPP guidelines indicate an increasing emphasis on evidence from randomized controlled trials from 2012 to 2021. The decline in the number of recommendations with LOE reported suggests an area for improvement in future guidelines as the presence of LOE is crucial to facilitate interpretation of clinical practice guidelines.
Natural land cover positively correlates with COVID-19 health outcomes
Authors: Li Chao , Managi Shunsuke
Published: March 2023

Background

The coronavirus disease 2019 (COVID‐19) poses special challenges for societies, as the disease causes millions of deaths. Although the direct prevention measures affect the prevalence and mortality the most, the other indirect factors, including natural environments and economics, could not be neglected. Evaluating the effect of natural land cover on COVID-19 health outcomes is an urgent and crucial public health topic.

Methods

Here, we examine the relationships between natural land cover and the prevalence and mortality of COVID-19 in the United States. To probe the effects of long-term living with natural land cover, we extract county-level land cover data from 2001 to 2019. Based on statistically spatial tests, we employ the Spatial Simultaneous Autoregressive (SAC) Model to estimate natural land cover’s impact and monetary values on COVID-19 health outcomes. To examine the short-term effects of natural environments, we build a seasonal panel data set about the greenery index and COVID-19 health outcomes. The panel SAC model is used to detect the relationship between the greenery index and seasonal COVID-19 health outcomes.

Results

A 1% increase in open water or deciduous forest is associated with a 0.004-death and 0.163-conformed-case, or 0.006-death and 0.099-confirmed-case decrease in every 1,000 people. Converting them into monetary value, for the mortality, a 1% increase in open water, deciduous forest, or evergreen forest in a county is equivalent to a 212-, 313-, or 219-USD increase in household income in the long term. Moreover, for the prevalence, a 1% change in open water, deciduous forest, or mixed forest is worth a 382-, 230-, or 650-USD increase in household income. Furthermore, a rational development intensity is also critical to reduce the risk of the COVID-19 pandemic. More greenery in the short term is also linked to lower prevalence and mortality.

Conclusions

Our study underscores the importance of incorporating natural land cover as a means of mitigating the risks and negative consequences of future pandemics like COVID-19 and promoting overall public health.
Experiences of oncology healthcare personnel in international medical service quality: a phenomenological study
Authors: Lai Chi-Chun , Chen Shih-Ying , Chen Hsien-Wei , Li Hsueh-Yu , Hsu Hsiang-Hao , Chen Li-Chin , Tang Woung-Ru
Published: March 2023

Background

With the globalization of medical services on the rise, Asia has ascended to a destination of choice for its high-quality medical services at very reasonable rates. Monitoring the quality of the international medical industry is vital to maintain service demand. The experiences of healthcare personnel (HCP) involved in international medical services (IMS) regarding the provision of services to international cancer patients have not yet been discussed. This study aimed to explore oncology HCP experiences of IMS quality in caring for international cancer patients in Taiwan.

Methods

Descriptive phenomenological method and were analyzed through Colaizzi’s seven-step approach. In this study, 19 respondents were collected data by using in-depth semi-structured interviews. An average interview lasted approximately 45 min.

Results

Four major themes were identified from the interviews: patient selection, psycho-oncology care, predicaments, and promoting suggestions. Additionally, thirteen subthemes emerged, including necessary selection of patients, reasons for unwillingness to enroll international patients, helpless patients, emotional distress, care with warmth, insufficient manpower, an unfair reward mechanism, poor hardware equipment, the predicaments of oncology care, various publicity strategies, one-on-one service model, design of a designated area, and reasonable benefit distribution.

Conclusions

This study explored oncology HCP experiences of IMS quality in caring for international cancer patients, with implications for hospitals in developing high-quality IMS. Due to the fact that IMS is a global trend, HCPs, administrators, and policy-makers are advised to improve the quality of IMS in the oncology department, which has been the least studied field in IMS quality.
Factors that shape recurrent miscarriage care experiences: findings from a national survey
Authors: Flannery Caragh , Hennessy Marita , Dennehy Rebecca , Matvienko-Sikar Karen , Lucey Con , Dhubhgain Jennifer Ui , O’Donoghue Keelin
Published: March 2023

Background

Learning what matters to women/couples with recurrent miscarriage (RM) is essential to inform service improvement efforts and future RM care practices. Previous national and international surveys have examined inpatient stays, maternity care, and care experiences around pregnancy loss, but there is little focus on RM care. We aimed to explore the experiences of women and men who have received RM care and identify patient-centred care items linked to overall RM care experience.

Methods

Between September and November 2021, we invited people who had experienced two or more consecutive first trimester miscarriages and received care for RM in Ireland in the ten-year period prior to participate in a cross-sectional web-based national survey. The survey was purposefully designed and administered via Qualtrics. It included questions on sociodemographics, pregnancy and pregnancy loss history, investigation and treatment for RM, overall RM care experience, and patient-centred care items at various stages of the RM care pathway such as respect for patients' preferences, information and support, the environment, and involvement of partners/family. We analysed data using Stata.

Results

We included 139 participants (97% women, n = 135) in our analysis. Of the 135 women, 79% were aged 35–44 years (n = 106), 24% rated their overall RM care experience as poor (n = 32), 36% said the care they received was much worse than expected (n = 48), and 60% stated health care professionals in different places did not work well together (n = 81). Women were more likely to rate a good care experience if they had a healthcare professional to talk to about their worries/fears for RM investigations (RRR 6.11 [95% CI: 1.41–26.41]), received a treatment plan (n = 70) (RRR 3.71 [95% CI: 1.28–10.71]), and received answers they could understand in a subsequent pregnancy (n = 97) (RRR 8 [95% CI: 0.95–67.13]).

Conclusions

While overall experience of RM care was poor, we identified areas that could potentially improve people’s RM care experiences – which have international relevance – such as information provision, supportive care, communication between healthcare professionals and people with RM, and care coordination between healthcare professionals across care settings.
Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010–2018
Authors: Nyawanda Bryan O. , Murunga Nickson , Otieno Nancy A. , Bigogo Godfrey , Nyiro Joyce U. , Vodicka Elisabeth , Bulterys Marc , Nokes D. James , Munywoki Patrick K. , Emukule Gideon O.
Published: March 2023

Background

Respiratory syncytial virus (RSV) is among the leading childhood causes of viral pneumonia worldwide. Establishing RSV-associated morbidity and mortality is important in informing the development, delivery strategies, and evaluation of interventions.

Methods

Using data collected during 2010–2018 from base regions (population-based surveillance studies in western Kenya and the Kilifi Health and Demographic Surveillance Study), we estimated age-specific rates of acute respiratory illness (ARI), severe acute respiratory illness (SARI—defined as hospitalization with cough or difficulty breathing with onset within the past 10 days), and SARI-associated deaths. We extrapolated the rates from the base regions to other regions of Kenya, while adjusting for risk factors of ARI and healthcare seeking behavior, and finally applied the proportions of RSV-positive cases identified from various sentinel and study facilities to the rates to obtain regional age-specific rates of RSV-associated outpatient and non-medically attended ARI and hospitalized SARI and severe ARI that was not hospitalized (non-hospitalized SARI). We applied age-specific RSV case fatality ratios to SARI to obtain estimates of RSV-associated in- and out-of-hospital deaths.

Results

Among Kenyan children aged < 5 years, the estimated annual incidence of outpatient and non-medically attended RSV-associated ARI was 206 (95% credible interval, CI; 186–229) and 226 (95% CI; 204–252) per 1000 children, respectively. The estimated annual rates of hospitalized and non-hospitalized RSV-associated SARI were 349 (95% CI; 303–404) and 1077 (95% CI; 934–1247) per 100,000 children respectively. The estimated annual number of in- and out-of-hospital deaths associated with RSV infection in Kenya were 539 (95% CI; 420–779) and 1921 (95% CI; 1495–2774), respectively. Children aged < 6 months had the highest burden of RSV-associated severe disease: 2075 (95% CI; 1818–2394) and 44 (95% CI 25–71) cases per 100,000 children for hospitalized SARI and in-hospital deaths, respectively.

Conclusions

Our findings suggest a substantial disease burden due to RSV infection, particularly among younger children. Prioritizing development and use of maternal vaccines and affordable long-lasting monoclonal antibodies could help reduce this burden.
Positive association between stress hyperglycemia ratio and pulmonary infection in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention
Authors: Lin Zehuo , Liang Xueqing , Zhang Yeshen , Dai Yining , Zeng Lin , Chen Weikun , Kong Siyu , He Pengcheng , Duan Chongyang , Liu Yuanhui
Published: March 2023

Background

Previous studies have shown that the stress hyperglycemia ratio (SHR), a parameter of relative stress-induced hyperglycemia, is an excellent predictive factor for all-cause mortality and major adverse cardiovascular events (MACEs) among patients with ST-segment elevation myocardial infarction (STEMI). However, its association with pulmonary infection in patients with STEMI during hospitalization remains unclear.

Methods

Patients with STEMI undergoing percutaneous coronary intervention (PCI) were consecutively enrolled from 2010 to 2020. The primary endpoint was the occurrence of pulmonary infection during hospitalization, and the secondary endpoint was in-hospital MACEs, composed of all-cause mortality, stroke, target vessel revascularization, or recurrent myocardial infarction.

Results

A total of 2,841 patients were finally included, with 323 (11.4%) developing pulmonary infection and 165 (5.8%) developing in-hospital MACEs. The patients were divided into three groups according to SHR tertiles. A higher SHR was associated with a higher rate of pulmonary infection during hospitalization (8.1%, 9.9%, and 18.0%, P < 0.001) and in-hospital MACEs (3.7%, 5.1%, and 8.6%, P < 0.001). Multivariate logistic regression analysis demonstrated that SHR was significantly associated with the risk of pulmonary infection during hospitalization (odds ratio [OR] = 1.46, 95% confidence interval [CI] 1.06–2.02, P = 0.021) and in-hospital MACEs (OR = 1.67, 95% CI 1.17–2.39, P = 0.005) after adjusting for potential confounding factors. The cubic spline models demonstrated no significant non-linear relationship between SHR and pulmonary infection (P = 0.210) and MACEs (P = 0.743). In receiver operating characteristic curve, the best cutoff value of SHR for pulmonary infection was 1.073.

Conclusions

The SHR is independently associated with the risk of pulmonary infection during hospitalization and in-hospital MACEs for patients with STEMI undergoing PCI.
The independent association of myocardial extracellular volume and myocardial blood flow with cardiac diastolic function in patients with type 2 diabetes: a prospective cross-sectional cohort study
Authors: Bojer Annemie S. , Sørensen Martin H. , Madsen Stine H. , Broadbent David A. , Plein Sven , Gæde Peter , Madsen Per L.
Published: March 2023

Background

Diffuse myocardial fibrosis and microvascular dysfunction are suggested to underlie cardiac dysfunction in patients with type 2 diabetes, but studies investigating their relative impact are lacking. We aimed to study imaging biomarkers of these and hypothesized that fibrosis and microvascular dysfunction would affect different phases of left ventricular (LV) diastole.

Methods

In this cross-sectional study myocardial blood flow (MBF) at rest and adenosine-stress and perfusion reserve (MPR), as well as extracellular volume fraction (ECV), were determined with cardiovascular magnetic resonance (CMR) imaging in 205 patients with type 2 diabetes and 25 controls. Diastolic parameters included echocardiography-determined lateral e’ and average E/e’, and CMR-determined (rest and chronotropic-stress) LV early peak filling rate (ePFR), LV peak diastolic strain rate (PDSR), and left atrial (LA) volume changes.

Results

In multivariable analysis adjusted for possible confounders including each other (ECV for blood flow and vice versa), a 10% increase of ECV was independently associated with ePFR/EDV (rest: β = − 4.0%, stress: β = − 7.9%), LAmax /BSA (rest: β = 4.8%, stress: β = 5.8%), and circumferential (β = − 4.1%) and radial PDSR (β = 0.07%/sec). A 10% stress MBF increase was associated with lateral e′ (β = 1.4%) and average E/e’ (β = − 1.4%) and a 10% MPR increase to lateral e′ (β = 2.7%), and average E/e’ (β = − 2.8%). For all the above, p < 0.05. No associations were found with longitudinal PDSR or left atrial total emptying fraction.

Conclusion

In patients with type 2 diabetes, imaging biomarkers of microvascular dysfunction and diffuse fibrosis impacts diastolic dysfunction independently of each other. Microvascular dysfunction primarily affects early left ventricular relaxation. Diffuse fibrosis primarily affects diastasis.

Trial registrationhttps://www.clinicaltrials.gov. Unique identifier: NCT02684331. Date of registration: February 18, 2016.
Surgical ablation for atrial fibrillation: impact of Diabetes Mellitus type 2
Authors: Kogan Alexander , Grupper Avishay , Sabbag Avi , Ram Eilon , Jamal Tamer , Nof Eyal , Fisman Enrique Z. , Levin Shany , Beinart Roy , Frogel Jonathan , Raanani Ehud , Sternik Leonid
Published: March 2023

Background

Diabetes mellitus (DM) type 2 is an independent risk factor for atrial fibrillation (AF). Surgical ablation or "maze procedure" is an option for patients with AF undergoing concomitant or isolated cardiac surgery. The aim of this study was to evaluate the impact of DM type 2 on early and long-term outcomes of patients following surgical AF ablation.

Methods

We performed an observational cohort study in Israel’s largest tertiary care center. All data of patients who underwent surgical AF ablation, between 2006 and 2021 were extracted from our departmental database. Patients were divided into Group I (non-diabetic patients) and Group II (DM type 2 patients). We compared the two groups with respect to freedom from recurrent atrial arrhythmia, and mortality rate.

Results

The study population included 606 patients. Group I (non-DM patients), consisting of 484 patients, and Group II (DM type 2 patients), comprised 122 patients. Patients with DM were older, had more hypertension and incidence of cerebrovascular accident (CVA)/transient ischemic attack (TIA), higher EuroSCORE (p < .05 for all), and a longer bypass time—130 ± 40 vs. 122 ± 36 min (p = 0.028). The mean follow-up duration was 39.0 ± 22.7 months. Freedom from atrial fibrillation was similar between the non-DM and DM type 2 groups after a 1-year follow-up, 414 (88.2%) vs. 101 (87.1%) (p = 0.511), after a 3-year follow-up, 360 (86.3%) vs. 84 (79.9%) (p = 0.290) and after a 5-year follow-up, 226 (74.1%) vs. 55 (71.5%) (p = 0.622) respectively. Furthermore, 1- and 3-year mortality was similar between non-DM and DM type 2 groups, 2.5% vs. 4.9%, (p = 0.226) and 5.6% vs. 10.5% (p = 0.076) respectively. 5-year mortality was higher in Group II (DM type 2 patients) compared with Group I (non-DM patients), 11.1% vs. 23.4% (p = 0.009).

Conclusion

Surgical ablation had a high success rate, with freedom from recurrent atrial arrhythmia at 1- 3- and 5- years follow-up in both the DM type 2 and non-DM groups. Furthermore,1- and 3-year mortality after surgical ablation was also similar in both groups. However, 5-year mortality was higher in the DM type 2 group.
Assessment of the distribution of human and material resources for eye health in the public sector in Nampula, Mozambique
Authors: Sengo Dulnério Barbosa , Salamo Zubair Momade Abudo , dos Santos Isaura Ilorena d’Alva Brito , Mate Laura Mavota , Chivinde Sancho Manuel , Moragues Raul , Pérez Pablo Caballero , López-Izquierdo Inmaculada
Published: March 2023

Background

The unavailability of human and material resources can affect access to eye health services, constituting an obstacle in the fight against avoidable visual impairment. This study aimed to assess the availability and distribution of human and material resources for eye health in the public sector in Nampula province.

Methods

A mixed method approach was used, which included document reviews (to extract information regarding the number of professionals and inhabitants in each district) and application of a questionnaire to heads of the ophthalmology department in each health facility (to obtain the list of available equipment). The ratios of eye health professionals per population in Nampula province and each of its districts were calculated and evaluated taking into account the recommendations of the World Health Organization (WHO). Based on the level of care of each health facility, the availability of equipment was evaluated.

Results

Nampula Province has not reached the recommended ratio of eye health professionals per population in the different categories (ophthalmic technicians with 0.8 per 100 thousand inhabitants; optometrists and ophthalmologists with 0.4 and 0.2 per 250 thousand inhabitants, respectively). Most districts of Nampula did not reach the recommended ratio in the three categories of professionals, except Nampula City (provincial capital). However, there was a greater concentration of professionals and facilities with eye health services in the provincial capital. Primary and secondary level health facilities lacked some equipment to provide eye health services within their scope.

Conclusions

There is an unequal distribution of the workforce in Nampula and the centralization of surgical services at the Central Hospital of Nampula level. Therefore, there is a need to review resource distribution strategies and decentralization policy of eye health services in Nampula.
Specific interpretation biases as a function of social anxiety and callous-unemotional traits in a community and a clinical adolescent sample
Authors: Dapprich Anna L. , Becker Eni S. , Derks Laura M. , Legenbauer Tanja , Lange Wolf-Gero
Published: March 2023

Background

Threatening and hostile interpretation biases are seen as causal and maintaining mechanisms of childhood anxiety and aggression, respectively. However, it is unclear whether these interpretation biases are specific to distinct problems or whether they are general psychopathological phenomena. The specificity versus pervasiveness of interpretation biases could also differ depending on mental health status. Therefore, in the current study, we investigated whether social anxiety and callous-unemotional (CU) traits were uniquely related to threatening and hostile interpretation biases, respectively, in both a community and a clinical sample of adolescents.

Methods

A total of 161 adolescents between 10 to 15 years of age participated. The community sample consisted of 88 participants and the clinical sample consisted of 73 inpatients with a variety of psychological disorders. Social anxiety and CU-traits were assessed with self-report questionnaires. The Ambiguous Social Scenario Task was used to measure both threatening and hostile interpretations in response to written vignettes.

Results

Results showed that social anxiety was uniquely related to more threatening interpretations, while CU-traits were uniquely related to more hostile interpretations. These relationships were replicated for the community sample. For the clinical sample, only the link between social anxiety and threatening interpretations was significant. Explorative analyses showed that adolescents with externalizing disorders scored higher on hostile interpretations than adolescents with internalizing disorders.

Conclusions

Overall, these results support the content-specificity of threatening interpretation biases in social anxiety and of hostile interpretation biases in CU-traits. Better understanding the roles of interpretation biases in different psychopathologies might open avenues for tailored prevention and intervention paradigms.
Effects of 5α-dihydrotestosterone on the modulation of monocyte/macrophage response to Staphylococcus aureus: an in vitro study
Authors: Dos Santos Déborah Cruz , de Souza Bittencout Rafaela , Arêas Iago Dórea , Pena Larissa Silva C. , Almeida Carolline Florentino , de Brito Guimarães Bruna Carolina , Dórea Rafael Santos Dantas Miranda , Correia Thiago Macêdo Lopes , Júnior Manoel Neres Santos , Morbeck Lorena Lôbo Brito , Dos Santos Talita Costa , Souza Clarissa Leal S. , de Souza Samira Itana , de Jesus Soares Telma , Yatsuda Regiane , Campos Guilherme Barreto , Marques Lucas Miranda
Published: March 2023

Background

Staphylococcus aureus (S. aureus) is a pathogen responsible for a wide range of clinical manifestations and potentially fatal conditions. There is a paucity of information on the influence of androgens in the immune response to S. aureus infection. In this study, we evaluated the influence of the hormone 5α-dihydrotestosterone (DHT) on mouse peritoneal macrophages (MPMs) and human peripheral blood monocytes (HPBMs) induced by S. aureus.

Methods

An in vitro model of MPMs from BALB/c sham males, orchiectomised (OQX) males, and females was used. Cells were inoculated with 10 μL of S. aureus, phage-type 80 or sterile saline (control) for 6 h. The MPMs of OQX males and females were pre-treated with 100 μL of 10–2 M DHT for 24 h before inoculation with S. aureus. The concentration of the cytokines TNF-α, IL-1α, IL-6, IL-8, and IL-10; total nitrites (NO−2); and hydrogen peroxide (H2O2) were measured in the supernatant of MPM cultures. In addition, the toll-like receptor 2 (TLR2) and nuclear factor kappa B (NF-kB) genes that are involved in immune responses were analysed. For the in vitro model of HPBMs, nine men and nine women of childbearing age were selected and HPBMs were isolated from samples of the volunteers’ peripheral blood. In women, blood was collected during the periovulatory period. The HPBMs were inoculated with S. aureus for 6 h and the supernatant was collected for the analysis of cytokines TNF-α, IL-6, IL-12; and GM-CSF, NO−2, and H2O2. The HPBMs were then removed for the analysis of 84 genes involved in the host’s response to bacterial infections by RT-PCR array. GraphPad was used for statistical analysis with a p value < 0.05.

Results

Our data demonstrated that MPMs from sham males inoculated with S. aureus displayed higher concentrations of inflammatory cytokines and lower concentrations of IL-10, NO−2, and H2O2 when compared with MPMs from OQX males and females. A similar result was observed in the HPBMs of men when compared with those of women. Previous treatment with DHT in women HPBMs increased the production of pro-inflammatory cytokines and decreased the levels of IL-10, NO−2, and H2O2. The analysis of gene expression showed that DHT increased the activity of the TLR2 and NF-kB pathways in both MPMs and HPBMs.

Conclusions

We found that DHT acts as an inflammatory modulator in the monocyte/macrophage response induced by S. aureus and females exhibit a better immune defence response against this pathogen.
The first two mitochondrial genomes from Apiotrichum reveal mitochondrial evolution and different taxonomic assignment of Trichosporonales
Authors: Li Qiang , Xiao Wenqi , Wu Peng , Zhang Ting , Xiang Peng , Wu Qian , Zou Liang , Gui Mingying
Published: March 2023

Apiotrichum is a diverse anamorphic basidiomycetous yeast genus, and its mitogenome characterization has not been revealed. In this study, we assembled two Apiotrichum mitogenomes and compared them with mitogenomes from Agaricomycotina, Pucciniomycotina and Ustilaginomycotina. The mitogenomes of Apiotrichum gracile and A. gamsii comprised circular DNA molecules, with sizes of 34,648 bp and 38,096 bp, respectively. Intronic regions were found contributed the most to the size expansion of A. gamsii mitogenome. Comparative mitogenomic analysis revealed that 6.85–38.89% of nucleotides varied between tRNAs shared by the two Apiotrichum mitogenomes. The GC content of all core PCGs in A. gamsii was lower than that of A. gracile, with an average low value of 4.97%. The rps3 gene differentiated the most among Agaricomycotina, Pucciniomycotina and Ustilaginomycotina species, while nad4L gene was the most conserved in evolution. The Ka/Ks values for cob and rps3 genes were > 1, indicating the two genes may be subjected to positive selection in Agaricomycotina, Pucciniomycotina and Ustilaginomycotina. Frequent intron loss/gain events and potential intron transfer events have been detected in evolution of Agaricomycotina, Pucciniomycotina and Ustilaginomycotina. We further detected large-scale gene rearrangements between the 19 mitogenomes from Agaricomycotina, Pucciniomycotina and Ustilaginomycotina, and fifteen of the 17 mitochondrial genes shared by Apiotrichum varied in gene arrangements. Phylogenetic analyses based on maximum likelihood and Bayesian inference methods using a combined mitochondrial gene dataset revealed different taxonomic assignment of two Apiotrichum species, wherein A. gamsii had a more closely relationship with Trichosporon asahii. This study served as the first report on mitogenomes from the genus Apiotrichum, which promotes the understanding of evolution, genomics, and phylogeny of Apiotrichum.
Anatomy of the convective geothermal system from geophysical and hydrochemical data: A case study from the Changshou geothermal field, South China
Authors: Cheng Yuanzhi , Wang Cheng , Da Wenwei , Kong Yanlong , Hu Xiangyun
Published: March 2023

There are abundant low-medium temperature geothermal resources in southern China; however, a lack of research into their properties restricts the utilization of the geothermal energy. To expand the geothermal energy potential in southern China, it is vital to clarify the nonvolcanic geothermal system mechanisms. This study aimed to elucidate the mechanisms for the Changshou geothermal field, as a representative structurally controlled convective geothermal system, by analyzing the geophysical and hydrochemical data. The surface-to-subsurface (400 m depth) electrical resistivity structure of the geothermal field was obtained by 2D inversion of two intersecting controlled-source audio-frequency magnetotellurics and electrical resistivity tomography geophysical profiles. We identified the cap rock, reservoir, and fluid pathways of the geothermal system and verified them via drilling results. The cap was composed of Quaternary sediments and Cretaceous sandstone with moderate resistivity (10–50 Ωm), and the geothermal reservoir and fluid pathways were composed of dolomites and fracture zones with low resistivity (less than 5 Ωm), respectively. The hydrochemical results showed that the geothermal water was of the type HCO3·SO4−Ca·Mg, with low values of total dissolved solids resulting from shallow groundwater mixing. Isotope analyses indicated that the geothermal water was derived from precipitation in the Dahong Mountains, southeast of the geothermal field. The average temperature of the geothermal reservoir, as estimated by chalcedony and K-Mg geothermometers, was 53°C. Based on the geothermal gradient calculation, the circulation depth of the groundwater was 1500 m, with the circulation process driven by heat flows originating deep within the earth. The Changshou geothermal field was identified as a potential source of energy for residential heating in winter, owing to the large flow (2700 m3/d) and high permeability (24.03 m/d) of the geothermal reservoir.