bluuebunny/crossref_metadata_2025 huggingface dataset:
Biventricular Global Function Index Is Associated With Adverse Outcomes in Repaired Tetralogy of Fallot
Authors: Alsaied Tarek , Geva Tal , Graf Julia A. , Sleeper Lynn A. , Marie Valente Anne
Published: August 2021

Introduction:

Cardiac magnetic resonance (CMR) derived biventricular global function index (BVGFI) is a new CMR parameter that integrates biventricular volumes, mass, and function using clinically available CMR parameters. The associations of BVGFI with clinical outcomes in repaired tetralogy of Fallot are unknown.

Methods:

Patients with repaired tetralogy of Fallot who had a CMR before the occurrence of a composite outcome of death, resuscitated sudden death, or sustained ventricular tachycardia were studied. BVGFI was calculated as the average of right and left GFI. GFI was defined as (ventricular stroke volume×100)/(ventricular mean cavity volume + total ventricular myocardial volume). Ventricular mean cavity volume was defined as ([end-diastolic + end-systolic volume]/2). Cox multivariable regression analysis and classification and regression tree methodology were used.

Results:

Of the 736 eligible subjects (mean age at CMR 25.4±14.5 years), with a median follow-up of 28 months, 55 subjects (7.4%) reached the composite outcome (46 deaths and 9 sustained ventricular tachycardia). Independent associations with the composite outcome were as follows: BVGFI <37 (hazard ratio, 2.52;
P
=0.004), right ventricular end-systolic volume index >85 mL/m
2
(hazard ratio, 3.25;
P
<0.001), atrial tachycardia (hazard ratio, 2.03;
P
=0.021), and age at repair >2.5 years (hazard ratio, 3.37;
P
<0.001). Classification and regression tree analysis identified BVGFI as the most discriminatory CMR parameter associated with a high risk for adverse outcomes.

Conclusions:

BVGFI, a novel CMR-derived imaging biomarker combining biventricular volumes, mass, and function, may improve risk stratification for adverse clinical outcomes in patients with repaired tetralogy of Fallot.
Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop
Authors: Nayor Matthew , Shen Li , Hunninghake Gary M. , Kochunov Peter , Barr R. Graham , Bluemke David A. , Broeckel Ulrich , Caravan Peter , Cheng Susan , de Vries Paul S. , Hoffmann Udo , Kolossváry Márton , Li Huiqing , Luo James , McNally Elizabeth M. , Thanassoulis George , Arnett Donna K. , Vasan Ramachandran S.
Published: August 2021

Imaging genomics is a rapidly evolving field that combines state-of-the-art bioimaging with genomic information to resolve phenotypic heterogeneity associated with genomic variation, improve risk prediction, discover prevention approaches, and enable precision diagnosis and treatment. Contemporary bioimaging methods provide exceptional resolution generating discrete and quantitative high-dimensional phenotypes for genomics investigation. Despite substantial progress in combining high-dimensional bioimaging and genomic data, methods for imaging genomics are evolving. Recognizing the potential impact of imaging genomics on the study of heart and lung disease, the National Heart, Lung, and Blood Institute convened a workshop to review cutting-edge approaches and methodologies in imaging genomics studies, and to establish research priorities for future investigation. This report summarizes the presentations and discussions at the workshop. In particular, we highlight the need for increased availability of imaging genomics data in diverse populations, dedicated focus on less common conditions, and centralization of efforts around specific disease areas.
miR‐133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice
Authors: Akerman Adam W. , Collins Elizabeth N. , Peterson Andrew R. , Collins Lauren B. , Harrison Jessica K. , DeVaughn Amari , Townsend Jaleel M. , Vanbuskirk Rebecca L. , Riopedre‐Maqueira Jessica , Reyes Ailet , Oh Joyce E. , Raybuck Charles M. , Jones Jeffrey A. , Ikonomidis John S.
Published: August 2021

Background

Thoracic aortic aneurysms (TAAs) occur because of abnormal remodeling of aortic extracellular matrix and are accompanied by the emergence of proteolytically active myofibroblasts. The microRNA miR‐133a regulates cellular phenotypes and is reduced in clinical TAA specimens. This study tested the hypothesis that miR‐133a modulates aortic fibroblast phenotype, and overexpression by lentivirus attenuates the development of TAA in a murine model.

Methods and Results

TAA was induced in mice. Copy number of miR‐133a was reduced in TAA tissue and linear regression analysis confirmed an inverse correlation between aortic diameter and miR‐133a. Analyses of phenotypic markers revealed an mRNA expression profile consistent with myofibroblasts in TAA tissue. Fibroblasts were isolated from the thoracic aortae of mice with/without TAA. When compared with controls, miR‐133a was reduced, migration was increased, adhesion was reduced, and the ability to contract a collagen disk was increased. Overexpression/knockdown of miR‐133a controlled these phenotypes. After TAA induction in mice, a single tail‐vein injection of either miR‐133a overexpression or scrambled sequence (control) lentivirus was performed. Overexpression of miR‐133a attenuated TAA development. The pro‐protein convertase furin was confirmed to be a target of miR‐133a by luciferase reporter assay. Furin was elevated in this murine model of TAA and repressed by miR‐133a replacement in vivo resulting in reduced proteolytic activation.

Conclusions

miR‐133a regulates aortic fibroblast phenotype and over‐expression prevented the development of TAA in a murine model. These findings suggest that stable alterations in aortic fibroblasts are associated with development of TAA and regulation by miR‐133a may lead to a novel therapeutic strategy.
Effect of Heart Rate Variabilities on Outcome After Acute Intracerebral Hemorrhage: A Post Hoc Analysis of ATACH‐2
Authors: Miwa Kaori , Koga Masatoshi , Fukuda‐Doi Mayumi , Yamamoto Haruko , Tanaka Kanata , Yoshimura Sohei , Ihara Masafumi , Qureshi Adnan I. , Toyoda Kazunori
Published: August 2021

Background

To explore how the clinical impact of heart rate (HR) and heart rate variabilities (HRV) during the initial 24 hours after acute intracerebral hemorrhage (ICH) contribute to worse clinical outcomes.

Methods and Results

In the ATACH‐2 (Antihypertensive Treatment in Intracerebral Hemorrhage 2) trial, the HR was recorded for every 15 minutes from baseline to 1 hour and hourly during the initial 24 hours post‐randomization. We calculated the following: mean, standard deviation, coefficient of variation, successive variation, and average real variability (ARV). Outcomes were hematoma expansion at 24 hours and unfavorable functional outcome, defined as modified Rankin Scale score 4 to 6 at 90 days. Of the 1000 subjects in ATACH‐2, 994 with available HR data were included in the analyses. Overall, 262 experienced hematoma expansion, and 362 had unfavorable outcomes. Increased mean HR was linearly associated with unfavorable outcome (per 10 bpm increase adjusted odds ratio [aOR], 1.31, 95% CI, 1.14–1.50) but not with hematoma expansion, while HR‐ARV was associated with hematoma expansion (aOR, 1.06, 95% CI, 1.01–1.12) and unfavorable outcome (aOR, 1.07, 95% CI, 1.01–1.3). Every 10‐bpm increase in mean HR increased the probability of unfavorable outcome by 4.3%, while every 1 increase in HR‐ARV increased the probability of hematoma expansion by 1.1% and unfavorable outcome by 1.3%.

Conclusions

Increased mean HR and HR‐ARV within the initial 24 hours were independently associated with unfavorable outcome in acute ICH. Moreover, HR‐ARV was associated with hematoma expansion at 24 hours. This may have future therapeutic implications to accommodate HR and HRV in acute ICH.

Registration

URL:
https://www.clinicaltrials.gov
; Unique Identiﬁer: NCT01176565.
Association Between Patient Survival and Clinician Variability in Treatment Rates for Aortic Valve Stenosis
Authors: Brennan J. Matthew , Lowenstern Angela , Sheridan Paige , Boero Isabel J. , Thourani Vinod H. , Vemulapalli Sreekanth , Wang Tracy Y. , Liska Otto , Gander Stuart , Jager Jason , Leon Martin B. , Peterson Eric D.
Published: August 2021

Background

Patients with symptomatic severe aortic stenosis (ssAS) have a high mortality risk and compromised quality of life. Surgical/transcatheter aortic valve replacement (AVR) is a Class I recommendation, but it is unclear if this recommendation is uniformly applied. We determined the impact of managing cardiologists on the likelihood of ssAS treatment.

Methods and Results

Using natural language processing of Optum electronic health records, we identified 26 438 patients with newly diagnosed ssAS (2011–2016). Multilevel, multivariable Fine‐Gray competing risk models clustered by cardiologists were used to determine the impact of cardiologists on the likelihood of 1‐year AVR treatment. Within 1 year of diagnosis, 35.6% of patients with ssAS received an AVR; however, rates varied widely among managing cardiologists (0%, lowest quartile; 100%, highest quartile [median, 29.6%; 25th–75th percentiles, 13.3%–47.0%]). The odds of receiving AVR varied >2‐fold depending on the cardiologist (median odds ratio for AVR, 2.25; 95% CI, 2.14–2.36). Compared with patients with ssAS of cardiologists with the highest treatment rates, those treated by cardiologists with the lowest AVR rates experienced significantly higher 1‐year mortality (lowest quartile, adjusted hazard ratio, 1.22, 95% CI, 1.13–1.33).

Conclusions

Overall AVR rates for ssAS were low, highlighting a potential challenge for ssAS management in the United States. Cardiologist AVR use varied substantially; patients treated by cardiologists with lower AVR rates had higher mortality rates than those treated by cardiologists with higher AVR rates.
Pacemaker‐Based Cardiac Neuromodulation Therapy in Patients With Hypertension: A Pilot Study
Authors: Kalarus Zbigniew , Merkely Béla , Neužil Petr , Grabowski Marcin , Mitkowski Przemysław , Marinskis Germanas , Erglis Andrejs , Kaźmierczak Jarosław , Sturmberger Thomas , Sokal Adam , Pluta Slawomir , Gellér László , Osztheimer István , Malek Filip , Kolodzińska Agnieszka , Mika Yuval , Evans Steven J. , Hastings Harold M. , Burkhoff Daniel , Kuck Karl‐Heinz
Published: August 2021

Background

In prior unblinded studies, cardiac neuromodulation therapy (CNT) employing a sequence of variably timed short and longer atrioventricular intervals yielded sustained reductions of systolic blood pressure (SBP) in patients with hypertension. The effects of CNT on SBP were investigated in this double‐blind randomized pilot study.

Methods and Results

Eligible patients had daytime ambulatory SBP (aSBP) ≥130 mm Hg and office SBP ≥140 mm Hg despite taking ≥1 antihypertensive medication, and an indication for a dual‐chamber pacemaker. Patients underwent Moderato device implantation, which was programmed as a standard pacemaker during a 1‐month run‐in phase. Patients whose daytime aSBP was ≥125 mm Hg at the end of this period were randomized (1:1, double blind) to treatment (CNT) or control (CNT inactive). The primary efficacy end point was the between‐group difference of the change in 24‐hour aSBP at 6 months. Of 68 patients initially enrolled and who underwent implantation with the Moderato system, 47 met criteria for study continuation and were randomized (26 treatment, 21 control). The mean age was 74.0±8.7 years, 64% were men, left ventricular ejection fraction was 59.2%±5.7%, and aSBP averaged 141.0±10.8 mm Hg despite the use of 3.3±1.5 antihypertensive medications; 81% had isolated systolic hypertension. Six months after randomization, aSBP was 11.1±10.5 mm Hg (95% CI, −15.2 to −8.1 mm Hg) lower than prerandomization in the treatment group compared with 3.1±9.5 mm Hg (−7.4 to 1.2 mm Hg) lower in controls, yielding a net treatment effect of 8.1±10.1 mm Hg (−14.2 to −1.9 mm Hg) (
P
=0.012). There were no Moderato device– or CNT‐related adverse events.

Conclusions

CNT significantly reduced 24‐hour aSBP in patients with hypertension with a clinical indication for a pacemaker. The majority of patients had isolated systolic hypertension, a particularly difficult group of patients to treat.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02837445.
Early Repolarization in Pediatric Athletes: A Dynamic Electrocardiographic Pattern With Benign Prognosis
Authors: Halasz Geza , Cattaneo Mattia , Piepoli Massimo , Biagi Andrea , Romano Silvio , Biasini Vincenzo , Villa Michele , Cassina Tiziano , Capelli Bruno
Published: August 2021

Background

Early repolarization pattern (ERP) is considered a common training‐related and benign ECG finding in young adult athletes. Few data exist on ERP in the pediatric athletes population. Therefore, we aimed to evaluate the ERP prevalence, characteristics, and prognosis in pediatric athletes aged ≤16 years.

Methods and Results

Eight‐hundred eighty‐six consecutive pediatric athletes engaged in 17 different sports (mean age, 11.7±2.5 years; 7–16 years) were enrolled and prospectively evaluated with medical history, physical examination, resting and exercise ECGs, and transthoracic echocardiography during their preparticipation screening. Known cardiovascular diseases associated with sudden cardiac death was considered exclusion criteria. Athletes were followed up yearly for 4 years. The prevalence of ERP was 117 (13.2%), equally distributed in both sexes (
P
=0.072), irrespectively of body mass index and classification of sports. The most common ERP localizations were inferolateral and inferior leads (53.8% and 27.3%, respectively). Notching J‐point morphology was the most prevalent (70%), and rapidly ascending ST elevation (96%) was the most common ST‐segment morphology. Athletes with ERP were older (
P
<0.001) had lower rest and recovery heart rates (
P
<0.001), increased precordial and limb R‐wave voltages (
P
<0.001), increased R/S Sokolow index (
P
<0.001), and longer PR interval (
P
=0.006) in comparison with the athletes without ERP. Neither major cardiovascular nor arrhythmic events, nor sudden cardiac death were recorded over a median follow‐up of 4.2 years. One hundred seventeen (80.3%) athletes with ERP exhibited a persistent ERP. ERP localization and J‐point morphology changed during follow‐up in 11 (11.7%) and 17 (18%) of athletes, respectively.

Conclusions

ERP is common in pediatric athletes. It was mostly located in the inferolateral leads and associated with concave ascending ST segment with other training‐related ECG changes. The lack of either sudden cardiac death or cardiomyopathies linked to sudden cardiac death over follow‐up suggests that in pediatric athletes, ERP may be considered a benign training‐related ECG phenomenon with a potential dynamic pattern.
Postnatal Right Ventricular Developmental Track Changed by Volume Overload
Authors: Sun Sijuan , Hu Yuqing , Xiao Yingying , Wang Shoubao , Jiang Chuan , Liu Jinfen , Zhang Hao , Hong Haifa , Li Fen , Ye Lincai
Published: August 2021

Background

Current right ventricular (RV) volume overload (VO) is established in adult mice. There are no neonatal mouse VO models and how VO affects postnatal RV development is largely unknown.

Methods and Results

Neonatal VO was induced by the fistula between abdominal aorta and inferior vena cava on postnatal day 7 and confirmed by abdominal ultrasound, echocardiography, and hematoxylin and eosin staining. The RNA‐sequencing results showed that the top 5 most enriched gene ontology terms in normal RV development were energy derivation by oxidation of organic compounds, generation of precursor metabolites and energy, cellular respiration, striated muscle tissue development, and muscle organ development. Under the influence of VO, the top 5 most enriched gene ontology terms were angiogenesis, regulation of cytoskeleton organization, regulation of vasculature development, regulation of mitotic cell cycle, and regulation of the actin filament‐based process. The top 3 enriched signaling pathways for the normal RV development were PPAR signaling pathway, citrate cycle (Tricarboxylic acid cycle), and fatty acid degradation. VO changed the signaling pathways to focal adhesion, the PI3K‐Akt signaling pathway, and pathways in cancer. The RNA sequencing results were confirmed by the examination of the markers of metabolic and cardiac muscle maturation and the markers of cell cycle and angiogenesis.

Conclusions

A neonatal mouse VO model was successfully established, and the main processes of postnatal RV development were metabolic and cardiac muscle maturation, and VO changed that to angiogenesis and cell cycle regulation.
Comparative Effectiveness of Implantable Defibrillators for Asymptomatic Brugada Syndrome: A Decision‐Analytic Model
Authors: Khurshid Shaan , Chen Wanyi , Bode Weeranun D. , Wasfy Jason H. , Chhatwal Jagpreet , Lubitz Steven A.
Published: August 2021

Background

Optimal management of asymptomatic Brugada syndrome (BrS) with spontaneous type I electrocardiographic pattern is uncertain.

Methods and Results

We developed an individual‐level simulation comprising 2 000 000 average‐risk individuals with asymptomatic BrS and spontaneous type I electrocardiographic pattern. We compared (1) observation, (2) electrophysiologic study (EPS)‐guided implantable cardioverter‐defibrillator (ICD), and (3) upfront ICD, each using either subcutaneous or transvenous ICD, resulting in 6 strategies tested. The primary outcome was quality‐adjusted life years (QALYs), with cardiac deaths (arrest or procedural‐related) as a secondary outcome. We varied BrS diagnosis age and underlying arrest rate. We assessed cost‐effectiveness at $100 000/QALY. Compared with observation, EPS‐guided subcutaneous ICD resulted in 0.35 QALY gain/individual and 4130 cardiac deaths avoided/100 000 individuals, and EPS‐guided transvenous ICD resulted in 0.26 QALY gain and 3390 cardiac deaths avoided. Compared with observation, upfront ICD reduced cardiac deaths by a greater margin (subcutaneous ICD, 8950; transvenous ICD, 6050), but only subcutaneous ICD improved QALYs (subcutaneous ICD, 0.25 QALY gain; transvenous ICD, 0.01 QALY loss), and complications were higher. ICD‐based strategies were more effective at younger ages and higher arrest rates (eg, using subcutaneous devices, upfront ICD was the most effective strategy at ages 20–39.4 years and arrest rates >1.37%/year; EPS‐guided ICD was the most effective strategy at ages 39.5–51.3 years and arrest rates 0.47%–1.37%/year, and observation was the most effective strategy at ages >51.3 years and arrest rates <0.47%/year). EPS‐guided subcutaneous ICD was cost‐effective ($80 508/QALY).

Conclusions

Device‐based approaches (with or without EPS risk stratification) can be more effective than observation among selected patients with asymptomatic BrS. BrS management should be tailored to patient characteristics.
LFG Generation from Acyclic F-Structures is NP-Hard
Authors: Wedekind Jürgen , Kaplan Ronald M.
Published: August 2021

The universal generation problem for LFG grammars is the problem of determining whether a given grammar derives any terminal string with a given f-structure. It is known that this problem is decidable for acyclic f-structures. In this brief note, we show that for those f-structures the problem is nonetheless intractable. This holds even for grammars that are off-line parsable.
For 19-Month-Olds, What Happens On-Screen Stays On-Screen
Authors: Revencu Barbu , Csibra Gergely
Published: August 2021

Humans rely extensively on external representations such as drawings, maps, and animations. While animations are widely used in infancy research, little is known about how infants interpret them. In this study, we asked whether 19-month-olds take what they see on a screen to be happening here and now, or whether they think that on-screen events are decoupled from the immediate environment. In Experiments 1–3, we found that infants did not expect a falling animated ball to end up in boxes below the screen, even though they could track the ball (i) when the ball was real or (ii) when the boxes were also part of the animation. In Experiment 4, we tested whether infants think of screens as spatially bounded physical containers that do not allow objects to pass through. When two location cues were pitted against each other, infants individuated the protagonist of an animation by its virtual location (the animation to which it belonged), not by its physical location (the screen on which the animation was presented). Thus, 19-month-olds reject animation-reality crossovers but accept the depiction of the same animated environment on multiple screens. These results are consistent with the possibility that 19-month-olds interpret animations as external representations.
Multisensory Information Facilitates the Categorization of Untrained Stimuli
Authors: Wu Jie , Li Qitian , Fu Qiufang , Rose Michael , Jing Liping
Published: August 2021

Although it has been demonstrated that multisensory information can facilitate object recognition and object memory, it remains unclear whether such facilitation effect exists in category learning. To address this issue, comparable car images and sounds were first selected by a discrimination task in Experiment 1. Then, those selected images and sounds were utilized in a prototype category learning task in Experiments 2 and 3, in which participants were trained with auditory, visual, and audiovisual stimuli, and were tested with trained or untrained stimuli within the same categories presented alone or accompanied with a congruent or incongruent stimulus in the other modality. In Experiment 2, when low-distortion stimuli (more similar to the prototypes) were trained, there was higher accuracy for audiovisual trials than visual trials, but no significant difference between audiovisual and auditory trials. During testing, accuracy was significantly higher for congruent trials than unisensory or incongruent trials, and the congruency effect was larger for untrained high-distortion stimuli than trained low-distortion stimuli. In Experiment 3, when high-distortion stimuli (less similar to the prototypes) were trained, there was higher accuracy for audiovisual trials than visual or auditory trials, and the congruency effect was larger for trained high-distortion stimuli than untrained low-distortion stimuli during testing. These findings demonstrated that higher degree of stimuli distortion resulted in more robust multisensory effect, and the categorization of not only trained but also untrained stimuli in one modality could be influenced by an accompanying stimulus in the other modality.
A new species of Xylopia (Annonaceae) from the Peruvian Amazon
Authors: PONTES-PIRES ALINE FERNANDES , MURRAY NANCY A. , JOHNSON DAVID M. , DE V. BARBOSA MARIA REGINA
Published: August 2021

N/A
New distributional record of Rotala juniperina (Lythraceae) for Asia with typification of three names
Authors: R. ARUN PRASANTH , SHARMA OSHIN A. , SARDESAI MILIND M.
Published: August 2021

Rotala juniperina, so far known only from East Africa, is reported here for the first time from peninsular India. The present paper encompasses a note on its taxonomy and distribution along with the designation of a lectotype for R. rotundifolia and epitypes for R. serpyllifolia and R. simpliciuscula.
A Synoptic View of the Onset of the Mid-Latitude QBO Signal
Authors: Silverman Vered , Lubis Sandro W. , Harnik Nili , Matthes Katja
Published: August 2021

The extratropical effect of the quasi-biennial oscillation (QBO), known as the Holton-Tan effect, is manifest as aweaker, warmer winter Arctic polar vortex during the east QBO phase. While previous studies have shown that the extratropical QBO signal is caused by the modified propagation of planetary waves in the stratosphere, the mechanism dominating the onset and seasonal development of the Holton-Tan effects remains unclear. Here, the governing wave-mean flow dynamics of the early winter extratropical QBO signal onset and its reversibility is investigated on a synoptic timescale with a finite-amplitude diagnostic using reanalysis and a chemistry-climate model. The extratropical QBO signal onset in October is found to primarily result from modulated stratospheric life-cycles of wave pulses entering the stratosphere from the troposphere, rather than from a modulation of their tropospheric wave source. A comprehensive analysis of the wave activity budget during fall, when the stratospheric winter polar vortex starts forming and waves start propagating up into the stratosphere, shows significant differences. During the east QBO phase, the deceleration of the mid-high latitude stratospheric zonal mean jet by the upward propagating wave pulses is less reversible, due to stronger dissipation processes, while during the west phase, a more reversible deceleration of the main polar vortex is found owing to the waves being dissipated at lower latitudes, accompanied by a weak but different response of the tropospheric subtropical jet. From this synoptic wave-event viewpoint, the early season onset of the Holton-Tan effect results from the cumulative effect of the QBO dependent wave-induced deceleration during the life cycle of individual upward wave pulses.
Tracing the Origin of the South Asian Summer Monsoon Precipitation and Its Variability Using a Novel Lagrangian Framework
Authors: Dey Dipanjan , Döös Kristofer
Published: August 2021

The water sources and their variability responsible for the South Asian summer monsoon precipitation were analyzed using Lagrangian atmospheric water-mass trajectories. The results indicated that evaporated waters from the central and south Indian Ocean are the major contributors to the South Asian summer monsoon rainfall, followed by the contribution from the local recycling (precipitated water that evapotranspirated from the South Asian landmass), the Arabian Sea, remote sources, and the Bay of Bengal. It was also found that although the direct contribution originating from the Bay of Bengal is small, it still provides a pathway for the atmospheric water that comes from other regions. This pathway is hence only crossing over the Bay of Bengal. The outcomes further revealed that the evaporated waters originating from the central and south Indian Ocean are responsible for the net precipitation over the coastal regions of the Ganges–Brahmaputra–Meghna Delta, northeast India, Myanmar, the foothills of the Himalayas, and central-east India. Evaporated waters from the Arabian Sea are mainly contributing to the rainfall over the western coast and west-central India. Summer monsoon precipitation due to the local recycling is primarily restricted to the Indo-Gangetic plain. No recycled precipitation was observed over the mountain chain along the west coast of India (Western Ghats). The month-to-month precipitation variation over South Asia was analyzed to be linked with the Somali low-level jet variability. The interannual variability of the South Asian summer monsoon precipitation was found to be mainly controlled by the atmospheric waters that were sourced and traveled from the central and south Indian Ocean.
Contemporary Management and Outcomes of Injuries to the Inferior Vena Cava: A Prospective Multicenter Trial From PROspective Observational Vascular Injury Treatment
Authors: Stonko David P , Azar Faris K. , Betzold Richard D. , Morrison Jonathan J. , Fransman Ryan B. , Holcomb John , Bee Tiffany , Fabian Timothy C. , Skarupa David J. , Stein Deborah M. , Kozar Rosemary A. , O’Connor James V. , Scalea Thomas M. , DuBose Joseph J. , Feliciano David V.
Published: August 2021

Introduction

Injuries to the inferior vena cava (IVC), while uncommon, have a high mortality despite modern advances. The goal of this study is to describe the diagnosis and management in the largest available prospective data set of vascular injuries across anatomic levels of IVC injury.

Methods

The American Association for the Surgery of Trauma PROspective Observational Vascular Injury Treatment (PROOVIT) registry was queried from November 2013 to January 2019. Demographics, diagnostic modalities, injury patterns, and management strategies were recorded and analyzed. Comparisons between anatomic levels were made using non-parametric Wilcoxon rank-sum statistics.

Results

140 patients from 19 institutions were identified; median age was 30 years old (IQR 23-41), 75% were male, and 62% had penetrating mechanism. The suprarenal IVC group was associated with blunt mechanism (53% vs 32%, P = .02), had lower admission systolic blood pressure, pH, Glasgow Coma Scale (GCS), and higher ISS and thorax and abdomen AIS than the infrarenal injury group. Injuries were managed with open repair (70%) and ligation (30% overall; infrarenal 37% vs suprarenal 13%, P = .01). Endovascular therapy was used in 2% of cases. Overall mortality was 42% (infrarenal 33% vs suprarenal 66%, P<.001). Among survivors, there was no difference in first 24-hour PRBC transfusion requirement, or hospital or ICU length of stay.

Conclusions

Current PROOVIT registry data demonstrate continued use of ligation extending to the suprarenal IVC, limited adoption of endovascular management, and no dramatic increase in overall survival compared to previously published studies. Survival is likely related to IVC injury location and total injury burden.
Effects of the COVID-19 Pandemic Nationwide Lockdown on Mental Health, Environmental Concern, and Prejudice Against Other Social Groups
Authors: Schiller Bastian , Tönsing Daniel , Kleinert Tobias , Böhm Robert , Heinrichs Markus
Published: August 2021

The COVID-19 pandemic has hit humanity globally. Besides its obvious threats to our physical health and economic stability, one can only speculate about the pandemic’s and its countermeasures’ psychosocial impacts. Here, we took advantage of a sample of healthy male participants who had completed psychosocial measures on mental health, environmental concern, and prejudice against asylum-seekers just before and during the nationwide lockdown in Germany in spring 2020. A follow-up assessment of 140 participants during the lockdown provided a unique opportunity to track psychosocial changes in a prospective longitudinal study design. In comparison to before the lockdown (1) mental health worsened, (2) environmental concern increased, and (3) prejudice against asylum-seekers decreased. Our study demonstrates psychosocial “side effects” of the pandemic that bring both challenges and opportunities for our society with regard to the handling of psychological reactions to this pandemic and further global crises, including climate change and mass migration.
Attribution Errors by People and Intelligent Machines
Authors: Hancock P. A. , Lee John D. , Senders John W.
Published: August 2021

Objective

To explore the ramifications of attribution errors (AEs), initially in the context of vehicle collisions and then to extend this understanding into the broader and diverse realms of all forms of human–machine interaction.

Background

This work focuses upon a particular topic that John Senders was examining at the time of his death. He was using the lens of attribution, and its associated errors, to seek to further understand and explore dyadic forms of driver collision.

Method

We evaluated the utility of the set of Senders’ final observations on conjoint AE in two-vehicle collisions. We extended this evaluation to errors of attribution generally, as applicable to all human–human, human–technology, and prospectively technology–technology interactions.

Results

As with Senders and his many other contributions, we find evident value in this perspective on how humans react to each other and how they react to emerging forms of technology, such as autonomous systems. We illustrate this value through contemporary examples and prospective analyses.

Applications

The comprehension and mitigation of AEs can help improve all interactions between people, between intelligent machines and between humans and the machines they work with.
Is change over time in psychotic symptoms related to social functioning?
Authors: Kwakernaak Sascha ,   GROUP Investigators, Cahn Wiepke , Janssen Richard
Published: August 2021

Objective:

In psychosis, treatment often focuses on symptom reduction whereas social functioning is also essential. In this study, we investigate positive psychotic symptoms and medication use in relation to social functioning over a 3-year time-period in 531 patients diagnosed with psychosis. Furthermore, relations of positive symptoms with needs for care and quality of life were also investigated.

Method:

Using repeated measures analysis, changes were measured over time. Hereafter, mixed model analyses were performed to determine the associations of social functioning, needs for care, and quality of life with psychotic symptoms and patient characteristics. Finally, we assessed differences in symptoms and medication dose between those with an increase and those with a decrease in social functioning.

Results:

Patients significantly improved in social functioning, while psychotic symptoms increased. Improvement in social functioning was associated with younger age, higher IQ, and lower social functioning at T1, but not with positive symptoms. Also, improvement in social functioning was found to be related to a decrease in the dose of clozapine. Improvement in social functioning occurs despite worsening of positive symptoms.

Conclusions:

The findings suggest the need to further explore the relation between symptomatology, social functioning, and medication use. In the treatment of psychotic disorders, one should reconsider the strong focus on reducing psychotic symptoms. The current focus needs to shift much more toward improving functional outcome, especially when the patient expresses a desire for change in this respect.
Melody, not Beat Perception, Predicts Rhythmic Error Detection
Authors: Nichols Bryan E. , Stambaugh Laura A.
Published: August 2021

The purpose of this study was to examine the relationships among beat perception, error detection, and musical experience. We presented monophonic rhythms using a piano timbre along with two measures of beat perception (Harvard Beat Finding and Interval Test [BFIT] and Goldsmiths Beat Alignment Test) and a measure of melodic error detection. College musicians’ ( N = 43) ability to detect rhythm errors was not significantly correlated to their ability to perceive beat alignment (Goldsmiths test) or tempo change (BFIT). Age was related to performance on only one of the measures, the BFIT test. A regression model yielded pitch error detection as the only significant predictor of rhythmic error detection. We suggest that college musicians already possess a requisite ability for beat processing that allows them to perform error detection. The lack of relationship between beat perception and rhythmic error detection is explained by this requisite ability in the population, and we promote future research for pitch and rhythm processing as it relates to rhythm perception or performance.
Revisiting knowledge distillation for light-weight visual object detection
Authors: Gao Tianze , Gao Yunfeng , Li Yu , Qin Peiyuan
Published: August 2021

An essential element for intelligent perception in mechatronic and robotic systems (M&RS) is the visual object detection algorithm. With the ever-increasing advance of artificial neural networks (ANN), researchers have proposed numerous ANN-based visual object detection methods that have proven to be effective. However, networks with cumbersome structures do not befit the real-time scenarios in M&RS, necessitating the techniques of model compression. In the paper, a novel approach to training light-weight visual object detection networks is developed by revisiting knowledge distillation. Traditional knowledge distillation methods are oriented towards image classification is not compatible with object detection. Therefore, a variant of knowledge distillation is developed and adapted to a state-of-the-art keypoint-based visual detection method. Two strategies named as positive sample retaining and early distribution softening are employed to yield a natural adaption. The mutual consistency between teacher model and student model is further promoted through a hint-based distillation. By extensive controlled experiments, the proposed method is testified to be effective in enhancing the light-weight network’s performance by a large margin.
From early to late adolescence: Effect of problematic mobile phone use on depression of adolescents
Authors: Kong Fanchang , Liu Guofeng , Gao Qiufeng , Deng Jianjun
Published: August 2021

Problematic mobile phone use can predict depression in adolescents, but few studies have thoroughly explored its internal mechanism. This study surveyed 1,768 Chinese adolescents in three educational levels (upper grades of elementary, junior middle, and high school levels) using a questionnaire. Results showed that (1) problematic mobile phone use significantly positively predicted adolescents’ depression after controlling for gender and age, (2) parent–child relationship played a mediating role between problematic mobile phone use and adolescents’ depression, and (3) adolescents’ educational level moderated relationships between problematic mobile phone use and parent–child relationship as well as parent–child relationship and depression. The negative effect of problematic mobile phone use on the parent–child relationship and the impact of the parent–child relationship on depression are weakened as the educational level of adolescents increases. These findings indicated that problematic mobile phone use affects adolescents’ depression by reducing the quality of parent–child relationship, wherein the degree of influence reduces at high educational levels. Limitations and future directions of this study were also discussed.
Cultural Differences in Susceptibility to the End of History Illusion
Authors: Haas Brian W. , Omura Kazufumi
Published: August 2021

The End of History Illusion (EoHI) is the tendency to report that a greater amount of change occurred in the past than is predicted to occur in the future. We investigated if cultural differences exist in the magnitude of the EoHI for self-reported life satisfaction and personality traits. We found an effect of culture such that the difference between reported past and predicted future change was greater for U.S. Americans than Japanese, and that individual differences in two aspects of the self (self-esteem and self-concept clarity) mediated the link between culture and the magnitude of the EoHI. We also found a robust cultural difference in perceptions of past change; U.S. Americans tended to think about the past more negatively than their Japanese counterparts. These findings yield new insight onto the link between cultural context and the way people remember the past and imagine the future.
Dialogue as therapy: the role of the expert in the ICRP Dialogues
Authors: Takahashi M.
Published: August 2021

Science communication is commonly framed as a battle with ignorance and the field of radiological protection is not exempt from this tendency. By correcting deficits in the public’s understanding of science, the expert is often imagined to be able to convince the public of its objective safety (‘anzen’), thereby inspiring a sense of calm (‘anshin’). In the wake of the 2011 Fukushima Daiichi disaster, however, the International Commission on Radiological Protection has sought to break with this tradition by organising a series of participatory seminars in which experts engage those affected by the disaster as equals. Drawing on ethnographic fieldwork, this article suggests that the Dialogue seminars can be best understood using the metaphor of therapy; using it to describe the premise, form, and objectives of the Dialogues with a view to identifying good practice for future radiological protection scenarios.
Relationship Between Mobile Penetration Rate and Divorce Rate in Iran During 1995–2019: A Time-Series Study
Authors: Ahmadi Siroos
Published: August 2021

Mobile media, which comprise the main features of other media, can potentially influence many social issues. This time-series study aims to investigate the relationship between the mobile penetration rate and the growing divorce rate in Iran from 1995 to 2019. To specify the relationship, women’s participation in the labor force as a powerful social variable affecting the divorce rate was considered and modeled in the analysis. More specifically, the autoregressive distributed lag (ARDL) method was employed to measure the short and long-term relationships. The results indicated a significant positive relationship between the mobile penetration rate and the divorce rate in both short- and long-term periods; however, women’s participation in the labor force was not associated with the divorce rate.
Systematic review of health-related quality of life following thyroid cancer
Authors: Walshaw Emma G , Smith Mike , Kim Dae , Wadsley Jonathan , Kanatas Anastasios , Rogers Simon N.
Published: August 2021

This systematic review provides a summary of all studies published between 2000 and 2019 using a health-related quality of life (HRQOL) patient-completed questionnaire to report outcomes following diagnosis and treatment of thyroid cancer. The search terms were “thyroid cancer” or “thyroid carcinoma,” “quality of life” or “health related quality of life,” and “questionnaire” or “patient reported outcome.” EMBASE, PubMed, Medline, PsycINFO, CINAHL, and HaNDLE-On-QOL search engines were searched between 2 February and 23 February 2020. A total of 811 identified articles were reduced to 314 when duplicates were removed. After exclusion criteria (not thyroid specific, no quality of life questionnaires, and conference abstracts) were applied, 92 remained. Hand searching identified a further 2 articles. Of the 94 included, 16 had a surgical, 26 a primarily medical, and 52 a general focus. There were articles from 27 countries. A total of 49 articles were published from 2015 through 2019 inclusive. A total of 72 questionnaires were used among the articles and a range of 7 to 2215 participants were included within each article. This review demonstrated an increasing number of publications annually. The scope of enquiry into aspects of HRQOL following thyroid cancer is broad, with relatively few addressing surgical aspects and many focusing on the impact of radio-iodine. More research is required into shared decision-making in initial management decisions and HRQOL and interventions aimed specifically at addressing long-term HRQOL difficulties.
Research on Roadside Unit-Assisted Cooperative Positioning Method for a Connected Vehicle Environment
Authors: Liu Xue , Yang Tangtao , Chen Haiyang , Qiu Tony Z.
Published: August 2021

With the rapid development of intelligent transportation systems and connected vehicle (CV) technology, vehicle-to-infrastructure communication technologies have provided new solutions to traditional traffic safety and efficiency issues. However, the current intelligent CVs often provide positioning services only through a single GPS. These modules’ positioning accuracy can be insufficient to support the safety and reliability of security applications. The question arises of how to enhance GPS positioning accuracy in a CV environment without adding additional equipment and using only the information that existing CV devices can access. This paper proposes a roadside unit (RSU)-assisted GPS-RSS (received signal strength) cooperative positioning method for a CV environment. The rough position information from GPS is combined with RSS ranging and dead reckoning to obtain preliminary position estimated coordinates of the CV. Bayesian filtering is performed to obtain a more accurate preliminary position estimate. The final position estimated coordinates, obtained after data fusion, are combined with the high-precision map data (MAP) sent by the RSU to match the lane where the vehicle is located. Simulation and field tests verify each other, and the results show that the lane positioning accuracy of GPS can be improved by 21% within the range from the RSU to the CV’s on-board unit.
Bringing an Intersectional Lens to “Open” Science: An Analysis of Representation in the Reproducibility Project
Authors: Sabik Natalie J. , Matsick Jes L. , McCormick-Huhn Kaitlin , Cole Elizabeth R.
Published: August 2021

Feminist psychologists have called for researchers to consider the social and historical context and the multidimensionality of participants in research studies. The Reproducibility Project documents the degree to which the findings from mainstream psychological studies are reproduced. Drawing on intersectionality theory, we question the value of reproducing findings while ignoring who is represented, intersecting social and group identities, sociohistorical context, and the power and privilege that likely influence participants’ responses in psychology experiments. To critically examine the Reproducibility Project in psychology, we analyzed the 100 replication reports produced between 2011 and 2014 (Open Science Collaboration, 2015). We developed an intersectional analytic framework to investigate (a) representation, (b) whether demographic and identity factors were considered through a multidimensional or intersectional lens, (c) explanations of non-replication, and (d) whether socio-cultural context was considered. Results show that reports predominantly include WEIRD samples (people from Western, educated, industrialized, rich, and democratic countries). Context and identity were rarely considered, even when study design relied on these factors, and intersectional identities and structures (considering power, structural issues, discrimination, and historical context) were absent from nearly all reports. Online slides for instructors who want to use this article for teaching are available on PWQ's website at http://journals.sagepub.com/doi/suppl/10.1177/03616843211035678
Efficacy and safety of a novel hemostatic material, BoneStat, compared with Ostene and Bone Wax in a rat calvarial defect model
Authors: Choi Seon Young , Rhim Jiheon , Heo Seon A , Han Woo-Jung , Kim Myung Hee , Ha Chul-Won
Published: August 2021

Hemostasis has critical significance during surgical procedures. Bone Wax has traditionally been commonly used for bone hemostasis despite well-documented undesirable side effects: hindering osteogenesis and induction of inflammatory reactions with consequent increase in infection rates. A later developed formulation, Ostene, offers an alternative to Bone Wax with lesser undesired effects. In this study, BoneStat, a newly developed bone hemostatic formulation comprising water-soluble alkylene oxide co-polymers, was evaluated for water solubility, hemostatic efficacy, ease of handling, bone healing efficacy, and inflammatory reactions compared with Bone Wax and Ostene in a rat calvarial defect model. More than 95% of BoneStat was dissolved in water within 48 h, as was Ostene, but not Bone Wax. The time to hemostasis using BoneStat was significantly faster than with Ostene or Bone Wax. BoneStat also improved ease of handling compared to Ostene or BoneWax. BoneStat- and Ostene-treated groups constantly showed better bone healing than with Bone Wax. The BoneStat and Ostene groups presented no evidence of chronic inflammation reaction contrary to Bone Wax. These results suggest improved hemostasis, ease of handling, non-hindering bone healing, and unnoticeable chronic inflammatory reactions with BoneStat. Thus, Bonestat is a useful and reliable formulation for mechanical hemostasis.