bluuebunny/crossref_metadata_2025 huggingface dataset:
Problems of Iron Deficiency in Children and Adolescents: Diagnosis, Quality of Life, Treatment (Literature review)
Authors: Marushko Yurii , Moskovenko Olena
Published: October 2023

About 3 billion people of various age groups in all countries of the world suffer from iron deficiency (ID) in recent years. Iron is an important component of many biochemical reactions, and its deficiency causes a number of negative outcomes.
The review summarizes literature data on diagnosis, assessment of quality of life, and treatment of ID, which is one of the urgent problems of adolescence, because major changes in the body occur during puberty. A number of factors are involved in the genesis of iron deficiency: rapid growth of the organism, chronic diseases of the digestive tract, menstrual blood loss in teenage girls. The reason of iron deficiency is also insufficient intake of it into the organism. To diagnose anemia is not difficult on the base of a decrease of hemoglobin, blood color index and hematocrit, and the presence of characteristic symptoms. Timely detection of iron deficiency in the organism makes possible to correct it and improve the child’s condition.
The review includes the data of many clinical studies of ID in children and adolescents, the main laboratory criteria for diagnosis are defined. Special emphasis is placed on the effectiveness of using modern iron preparations with high clinical effectiveness and minimal side effects.
Pathogenetic Effects of Global Stress on the Dynamic Component of Benign Prostatic Hyperplasia in Men in Ukraine
Authors: Spyrydonenko Volodymyr , Gurzhenko Yurii
Published: October 2023

The military situation in Ukraine significantly worsened the quality of medical care for the population. Of all Ukrainian men the age category from 30 to 60 years old who take part in military operations is the most effective one. Another, no less important part of the male population is the old persons, who, as a result of military operations, have limited opportunities to receive medical care.
Currently, observing by urologist, required for benign prostatic hyperplasia (BPH) or lower urinary tract symptoms (LUTS) due to combat operations in the country, is often performed via distance curation. The doctor needs a clear understanding of the patient’s medical history, taking into account his psychological and somatic status, the use of medicines.
Stress negatively affects men’s health, worsening the hormonal background, mental state and aggravating problems of the genital and urinary systems. Psychological stress is a factor in the exacerbation or occurrence of urological complaints, which can lead to the pathological activation of certain parts of the sympathetic nervous and hormonal systems, the development of LUTS by BPH.
Tamsulosin is considered to be the most recognized and widely used treatment for LUTS in patients with BPH. The classic medicament approach of BPH monotherapy is the use of Serenoa repens extract. The distance appointment of selective α-adrenoblockers, both in monotherapy and in combinations, is an important measure of providing specialized urological care to the population.
Workshop Pemanfaatan Limbah Menjadi Kerajinan Tangan Dengan Tema "Peranan Akademisi Dalam Meningkatkan Pemberdayaan Fasilitas Dan Wawasan Masyarakat Kampung Ketupat Sebagai Aset Wisata Kota Samarinda"
Authors: Setyadi Hario Jati , Masa Amin Padmo Azam , Hairunnisa Namira Aida , Wanda Awang Muhammad Trielevy , Rabbani Zaki Fauzan
Published: October 2023

Kegiatan ini merupakan pengabdian masyarakat yang dilaksanakan di Auditorium Kantor Kecamatan Samarinda Seberang yang mengambil tema tempat di Kampung Ketupat, yaitu salah satu destinasi wisata yang terkenal di Kecamatan Samarinda Seberang serta mengundang salah satu pengrajin yang ada di Kampung Ketupat dan mengundang para siswa SMA/SMK untuk berpartisipasi dalam kegiatan ini. Fokus utama program ini adalah mengatasi masalah sampah dari sisa pembuatan ketupat yang tidak lagi memiliki nilai dimata orang – orang awam. Dalam upaya untuk membuat sampah memiliki nilai ekonomi, mengubah pola pikir dan perilaku masyarakat agar terbiasa memilah sampah, serta meningkatkan kualitas lingkungan menjadi lebih baik, kolaborasi antara peneliti dan masayrakat dilakukan dengan cara membuat workshop pemanfaatan limbah menjadi kerajinan tangan yang bernilai ekonomi. Melalui workshop pemanfaatan limbah menjadi kerajinan tangan, program ini berhasil memberikan dampak positif yang signifikan. Antusiasme para siswa SMA/SMK dan mahasiswa perguruan tinggi sangat besar untuk mempelajari bagaimana cara mengolah limbah yang tidak bernilai menjadi kerajinan yang bernilai ekonomi. Secara keseluruhan, program pengabdian masyarakat di Kampung Ketupat memberikan kontribusi positif dalam mengatasi masalah limbah yang awalnya tidak bernilai menjadi kerajinan yang bernilai ekonomi dan meningkatkan kualitas lingkungan menjadi lebih baik.
Pembuatan Video Alur Pelayanan Kepegawaian pada Sub Bagian Pembinaan di Kejaksaan Negeri Samarinda dengan Powtoon sebagai Media Informasi
Authors: Astuti Eka Desi Puji , Widagdo Putut Pamilih , Irsyad Akhmad
Published: October 2023

Kejaksaan Negeri Samarinda atau biasa disingkat KEJARI menggunakan Website dan Instagram sebagai pilihan platform media informasi. Konten dari Website dan Instagram mereka adalah desain yang berisikan tentang informasi kegiatan kejaksaan, seperti artikel, video, dan lainnya. Pembuatan video ini bertujuan agar memberi atau menambah informasi kepada para pegawai dalam pengajuan berkas kenaikan pangkat di Kejaksaan Negeri Samarinda. Proses pengambilan data diperoleh dari hasil observasi dan pengumpulan dokumen yang berhubungan dengan alur pelayanan kepegawaian sub bagian pembinaan pada Kejaksaan Negeri Samarinda. Pembuatan video ini menggunakan software Powtoon dengan menggunakan Metodologi Pengembangan Multimedia menurut Luther-Sutopo memiliki 6 (enam) tahap yaitu Concept, Design, Assembly, Testing, dan Ditribution. Berdasarkan kegiatan Praktik Kerja Lapangan yang telah dilakukan di Kejaksaan Negeri Kota Samarinda, dapat disimpulkan bahwa perlunya ada peningkatan dalam penerapan media informasi videografi untuk meningkatkan pengetahuan pegawai.
ANONİM ŞİRKETLERİN KAHRAMANMARAŞ MERKEZLİ DEPREMLERDEN SONRA YAPTIKLARI BAĞIŞLARA İLİŞKİN HUKUKİ DEĞERLENDİRMELER
Authors: KIRAN Süleyman
Published: October 2023

Ülkemizde yaşanan Kahramanmaraş merkezli depremlerin oluşturduğu tahribat oldukça fazladır. İlan edilen olağanüstü hâl ile birlikte, kamu kurumları da anılan doğal afetlerin ortaya çıkardığı olumsuz sonuçların ortadan kaldırılmasına yönelik kendi çalışma alanlarına ilişkin olarak birtakım tedbirleri içeren kararlar almışlardır. Ancak alınan kararlar, olumsuz sonuçların ortadan kaldırılmasına yönelik daha çok pratik çözümler içeren kararlardır. Alınan kararların insan hayatını ve hayat mücadelesini doğrudan ilgilendirmesi sebebiyle toplumda çok fazla hukuka uygunluk değerlendirilmesine tabi tutulmamıştır.

İçlerinde bankaların ve hatta Türkiye Cumhuriyet Merkez Bankası’nın da bulunduğu anonim şirketler Kahramanmaraş merkezli depremlerden sonra aralarında yürütülen yardımlaşma ve dayanışma kampanyalarına yüksek miktarlarda bağışlar yapmışlardır. Bu durum, doktrinde çok fazla çalışma konusu yapılmayan anonim şirketlerin doğal afetlerin sonrasında yaptıkları bağışlara ilişkin hukuki değerlendirme yapılması gerekliliğini ortaya çıkarmıştır. Bu ihtiyaca binaen, çalışmamızda Kahramanmaraş merkezli depremlerden sonra getirilen düzenlemelere ilişkin hukuki değerlendirmeler yapılacaktır.

Çalışmamızda mevcut hukuki durum, ortaya çıkması muhtemel hukuki sorunlar ve çözüm önerilerimizi ortaya koymaya çalışacağız. Hukuki sorumluluk kısmı ise, çalışmanın hacmi gözetilerek bu çalışmanın kapsamının dışında bırakılmıştır.
DEPREM BÖLGESİNDE BULUNAN YABANCILARIN HUKUKİ DURUMU: İKLİM MÜLTECİLİĞİ KARŞISINDA TÜRKİYE’NİN GÜNCEL SEYRELTME POLİTİKASI
Authors: ELÇİN Doğa
Published: October 2023

Çevresel nedenlerle göç, zorunlu göç kabul edilmektedir ve sınır aşıcı ya da ülke içinde yer değiştirmeye neden olmaktadır. Deprem, iklim mülteciliğine neden olan çevresel felaketlerden biridir. 6 Şubat depremleri iç göçe neden olmuştur. Depremden etkilenen iller yoğun olarak sınır aşıcı göç alan illerdir. Bu çalışmada, deprem bölgesinde bulunan yabancıların, iklim mülteciliği nedeniyle ülke içerisinde zorunlu olarak yer değiştirmeleri, Türkiye’nin güncel seyreltme politikası bağlamında değerlendirilmiştir. Öncelikle seyreltme politikası, yabancıların ülke içinde ikamet ve seyahat özgürlükleri bakımından incelenmiştir. Anayasal ilkeler değerlendirildikten sonra milletlerarası sözleşmeler ele alınmıştır. Ardından deprem bölgesi göç hareketliliği bakımından analiz edilmiştir. Deprem sonrasında bölgede bulunan yabancıların hukukî durumu araştırılmıştır. Deprem nedeniyle ülke içerisinde ani olarak zorunlu yer değiştirme, diğer bir deyişle iklim mülteciliğine ilişkin ulusal hukukta hüküm bulunmadığı tespit edilmiştir. Güncel seyreltme politikası karşısında iklim mülteciliği sorunu hukukî açıdan tartışılmış ve çözüm önerilerine yer verilmiştir.
Chytosan complex effect on layers productivity, their bones mineralization and egg shell quality
Authors:   FSBSI Federal Scientific Center “All-Russian Research and Technological Poultry Institute” (FSC ARRTPI), Moscow region, Russia, Yegorov Ivan , Yegorova Tatiana ,   FSBSI Federal Scientific Center “All-Russian Research and Technological Poultry Institute” (FSC ARRTPI), Moscow region, Russia, Frolov Vadim ,   “Agrohitin” LLC, Nizhny Novgorod, Russia
Published: October 2023

The research has shown that chitosan complex addition to layer feed 50 to 150 g per feed ton helps to increase egg production intensity by 0.8 to 2.1% and to reduce feed consumption by 1.1 to 1.8% and by 1.2 to 2.6% per ten eggs and 1 kg of egg mass respectively. Ash, calcium, phosphorus, zinc and copper content in experimental group layers tibia increased by 2.81 to 5.0%, 2.03 to 3.06%, 1.04 to 1.23%, 0.1 to 0.16 mg%, 0.64 to 1.82 mg% and 0.06 to 0.15mg% comparing to control group layers. Egg shell elastic deformation reduced to 18–19 µm from 21 µm for experimental group 47 weeks aged layers and egg shell thickness increased to 0.38 mm from 0.36 mm in control.
Consumer preferences of residents of the Moscow region for food eggs and egg products
Authors:   SCEI HE “Russian Customs Academy” (SCEI HE RCA), Moscow region, Russia, Krishtafovich Dmitry , Krishtafovich Valentina ,   SCEI HE “Russian Customs Academy” (SCEI HE RCA), Moscow region, Russia
Published: October 2023

The article is devoted to the study of consumer preferences and the study of satisfaction of the population of Moscow and the Moscow region with food eggs and egg products sold in the retail network.
Policy Strategy for The Use of Cantrang Fishing Tools
Authors: Syamsuddin Azrin , Fauzi Akhmad
Published: October 2023

This study aims to: 1) recommendations on the use of cantrang fishing gear (API) in Paciran District, Lamongan Regency, East Java, 2) integrating a participatory approach for the government and cantrang fishermen in their activities. Quantitative method, and purposive sample selection. Data collection October - November 2019. 20 respondents were selected for the multi-criteria assessment. Stakeholders consist of central and regional regulators, fisherman groups in the research location. Stakeholders know the options for action, and produce: 1) program-based evaluation of policies; 2) Evaluation based on Policies to Scenario. Hypotheses: a) Conservation, b) Economy, c) Integration, d) Smartfish. Data were analyzed using Multipol. The revitalization program and product quality are closer to the fish map and fisherman training programs. Conservation policies, closer to infrastructure programs, marine tourism, fish maps, and fishermen training. Each policy scores on the scenario, superior production policies on the demand side scenario, raw material and income policies have a higher score on the supply side scenario. Best average score on revenue policy, followed by raw materials, conservation and production. Income, conservation, production and raw material policies can be implemented in supply-side and demand-side scenarios. Results of Actions and Policy, the highest scores on marine tourism, infrastructure, fishermen training, and fish maps; The results of Action on Policy, marine tourism are determined by fishermen's infrastructure, and the quality of fishermen's products, raw material policies, supporting infrastructure programs, fish maps, and fishermen's training with the highest scores. Development of raw materials, relying on infrastructure, fish map technology, fishermen training, so that fishermen are more reliable. Scenario and Policy Results, policies on income, conservation, production and raw materials, can be implemented in supply side and demand side scenarios (infrastructure and marine tourism).
Language Views for Scientific Sensemaking Matter: A Synthesis of Research on Multilingual Students’ Experiences with Science Practices Through a Translanguaging Lens
Authors: González-Howard María , Andersen Sage , Méndez Pérez Karina , Suárez Enrique
Published: October 2023

This synthesis examines recent science education research on multilingual students’ experiences with language-rich science practices. Adopting a translanguaging lens, we explore how researchers’ language conceptualizations impact the science practices they study and the ways multilingual students are positioned. This analysis helps us understand the extent to which recent research is disrupting, or sustaining, minoritizing narratives about multilingual students and how they sensemake in science. Based on our findings, we suggest researchers: (1) reflect upon and expand their views of language, which will enable the field to develop more nuanced understandings of how language use across linguistic and multimodal resources permeates all science practices, and (2) consider how to expand multilingual students’ language repertoires for sensemaking while also valuing students’ existing language resources and practices.
Ciliated, Mitochondria-Rich Postmitotic Cells are Immune-privileged, and Mimic Immunosuppressive Microenvironment of Tumor-Initiating Stem Cells: From Molecular Anatomy to Molecular Pathway
Authors: Behnam Babak , Fazilaty Hassan , Ghadyani Mobina , Fadavi Pedram , Taghizadeh-Hesary Farzad
Published: October 2023

Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs) are a subset of the tumor population responsible for tumor resistance and relapse. Understanding the characteristics and shared features between tumor-initiating stem cells (TiSCs) and long-lived postmitotic cells may hold a key to better understanding the biology of cancer. Postmitotic cells have exited the cell cycle and are transitioned into a non-dividing and terminally differentiated state with a specialized function within a tissue. Conversely, a cancer cell with TiSC feature can divide and produce a variety of progenies, and is responsible for disease progression, tumor resistance to therapy and immune system and disease relapse. Surprisingly, our comprehensive evaluation of TiSCs suggests common features with long-lived post-mitotic cells. They are similar in structure (primary cilia, high mitochondrial content, and being protected by a barrier), metabolism (autophagy and senescence), and function (immunoescape and/or immune-privileged by a blood barrier). In-depth exploration showed how mitochondrial metabolism contributes to these shared features, including high energy demands arising from ciliary and microtubular functionality, increased metabolic activity, and movement. These findings can assist in decoding the remaining properties which offer insights into the biology of TiSCs, with potential implications for enhancing cancer treatment strategies and patient prognosis.
Characteristics of the Gut Microbiota in Young Adults with Autism Spectrum Disorder
Authors: Pang Xuying , Zhang Qiang , Wang Yuezhu , Zhan Yuzhi , Guo Min , Chen Bin , Li Quan , Zheng Huajun
Published: October 2023

Background: Although the characteristics of the gut microbiota of children with autism spectrum disorder (ASD) have been well studied, those of young adults with ASD have seldom been reported. Methods: Using 16S rRNA gene sequencing, we characterized the gut microbiota of 19 young adults with ASD and compared them with that of 19 healthy adults. A random forest prediction model was used to distinguish between the two groups at the genus level. Results: The abundance levels of one phylum, seven families, and 18 genera in adults with ASD were significantly different from those of controls. The genus Phascolarctobacterium was significantly enriched in adults with ASD, which might elicit ASD-like behavior through production of propionate. In addition, a random forest model identified 15 genera that could distinguish adults with ASD from healthy controls with areas under the receiver operating curve of 92.86%, and ten of them were biomarkers identified by LEfSe. Conclusions: Our results identified specific gut bacteria associated with ASD, and the successful application of certain genera in the prediction model further supports the association between gut microbiota and ASD.
Functional Cognitive Disorders in the Emergency Department
Authors: Larner Andrew J
Published: October 2023

Functional neurological disorders may present with cognitive symptoms as functional cognitive disorders. This narrative review addresses the diagnosis and differential diagnosis of functional cognitive disorders encountered in the emergency department setting. Functional cognitive disorders, like other functional neurological disorders, can be clinically suspected and may be positively diagnosed in the emergency department setting following careful diagnostic evaluation, rather than being a diagnosis of exclusion. However, the differential diagnosis is broad, and the possibility of either stroke or seizure in particular needs to be considered. Functional cognitive disorders can be positively diagnosed in the emergency department setting, as for other forms of functional neurological disorder, and hence directed onward to appropriate services.
SUBJECTS OF ENVY AMONG YOUNG MEN AND WOMEN: CONTEXTS OF DEVIANT BEHAVIOR
Authors:   Kharkiv National University of Internal Affairs, Nechitaylo Iryna , Miloradova Natalia ,   Kharkiv National University of Internal Affairs
Published: October 2023

This article explores the propensity for deviant behavior and the objects of envy among young men and women. Specifically, it examines the following aspects: Appearance: Young individuals often experience jealousy regarding each other's physical appearance, clothing, hairstyle, and more. Envy of attractive attributes may drive both genders to engage in deviant behaviors, such as resorting to drug use or alcohol abuse to achieve these attributes. Social Status: Envy can also revolve around social status, encompassing factors like popularity, academic or athletic success, and group affiliations. Envious feelings related to these aspects may lead to deviant behaviors, including the use of violence or manipulation to attain desired status. Material Goods: Material possessions can be a focal point of envy, motivating young people to engage in theft, deceit, or illicit activities to acquire them. Power and Control: Envy of power and control may serve as another motivator for deviant behavior. For instance, the desire to wield power can lead to attempts to control others or resort to violence to achieve personal objectives. Deviant behaviors often stem from envy, as individuals may seek to obtain desired objects or statuses through wrongful means. For instance, a young man envious of a successful classmate may resort to grade forgery or cheating to attain similar success. Jealousy can also trigger conflicts and violence among individuals. For example, two girls envious of each other's attractiveness or popularity may engage in efforts to undermine each other's lives or even resort to physical aggression. The primary objective of this article is to identify the principal psychological and legal characteristics of envy among male and female students within the context of deviant behavior. The article's objectives include assessing the level of envy among male and female cadets and exploring gender-specific relationships between deviant behavior and envy across various subject areas. It is essential to note that envy alone is not the sole cause of deviant behavior; rather, it is one of several factors influencing young individuals and motivating them to engage in unlawful acts. Additional factors, such as inadequate social support, low self-esteem, or negative environmental influences, also significantly contribute to the development of deviant behavior. In conclusion, this study underscores that envy is not a moral sentiment and highlights the centrality of feelings of inferiority in the experience of envy. Moreover, gender differences in envy, prevalent among youth, tend to diminish as individuals mature.
PSMG3 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that proteasome assembly chaperone 3, encoded by PSMG3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. PSMG3 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of PSMG3 in primary tumors was correlated with patient overall, distant metastasis-free and recurrence-free survival. Modulation of PSMG3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Explosive magnetic hypothesis of the Galaxy spiral structure in the history of the Earth.
Authors: Raf
Published: October 2023

The possibility of the formation of a triplet six-armed spiral structure of the Galaxy as a result of the impact on the stellar population of the Milky Way disk of concentrated ionized explosive supernova ejections (with different velocity extrema) from the central region is considered. A mechanism is proposed for concentration and acceleration by the magnetic field of the Galaxy R<3-5 kpc of ionized gas and dust emissions, with their further canalization along the magnetic axis of the dipole of a close binary system of supermassive objects at R<0.1 kpc, rotating with acceleration. The hypothesis is confirmed by the periodicity of pulses of electrically conductive cosmic dust entering the Earth, as well as by the presence of anisotropies of ultrahigh-energy cosmic rays >1014eV from the calculated directions. Thus, the triplet view of the boundaries of the geochronological scale is substantiated as the consequences of different-scale effects of heterogeneities in the triplet structure of the Spiral arms.
The Political Economy of Machine Learning in Healthcare
Authors: Egon Kaledio , KARL LETHO
Published: October 2023

A. Definition and context of the studyThe political economy of machine learning in healthcare refers to the analysis of the interplay between political and economic factors and the implementation of machine learning technologies within the healthcare sector. This entails examining how political decisions and economic incentives influence the adoption, development, and utilization of machine learning tools in healthcare settings. This study seeks to explore the complex relationship between politics, economics, and the application of machine learning in healthcare.B. Significance and relevance of the political economy of machine learning in healthcareThe significance of studying the political economy of machine learning in healthcare is evident in its potential to impact patient care, healthcare costs, and the healthcare industry as a whole. As machine learning algorithms and artificial intelligence technologies are integrated into healthcare, questions arise about access, equity, and the allocation of resources. Political decisions related to regulation, funding, and policy play a crucial role in determining how these technologies are used. Economic considerations, such as the cost-effectiveness of implementing machine learning solutions, are also critical factors. Understanding this intersection is vital for healthcare stakeholders, policymakers, and researchers to make informed decisions that promote equitable and efficient healthcare systems.C. Objectives and scope of the study "The Political Economy of Machine Learning in Healthcare"The study titled "The Political Economy of Machine Learning in Healthcare" aims to achieve several objectives within its scope:Analyzing Political Decision-Making: This study will investigate how political decisions, including legislation, regulation, and government funding, shape the implementation of machine learning in healthcare.Economic Impact Assessment: The research will assess the economic consequences of integrating machine learning in healthcare, including cost savings, investment requirements, and return on investment.Equity and Access: The study will explore the implications of machine learning in healthcare on equity and accessibility, examining how different socioeconomic groups are affected.Healthcare Outcomes: This research will analyze how machine learning affects healthcare outcomes, including diagnostic accuracy, patient outcomes, and quality of care.Industry Dynamics: The study will also consider how the adoption of machine learning influences the healthcare industry, such as changes in business models and the emergence of new players.
Advancements in Wireless Communication Technologies: A Comprehensive Review
Authors: Milson Smith , Orey Kurez
Published: October 2023

Advancements in Wireless Communication Technologies: A Comprehensive Review
TMEM9 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer )1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that transmembrane protein 9, encoded by TMEM9, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TMEM9 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of TMEM9 in primary tumors was correlated with patient overall survival. Modulation of TMEM9 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
AGRN is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that agrin, encoded by AGRN, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. AGRN mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of AGRN in primary tumors was correlated with patient overall and recurrence-free survival. Modulation of AGRN expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
P2RY2 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that purinergic receptor P2Y2, encoded by P2RY2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. P2RY2 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of P2RY2 in primary tumors was not correlated with patient survival. Modulation of P2RY2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Thống kê thương vong trong thiên nhiên
Authors: Hoàng Nguyễn Minh , Phương Lã Việt
Published: October 2023

Trong bài cuối cùng của cuốn sách Meandering Sobriety, có tiêu đề “Starving nature for gluttonous nature-loving humans” (“Bỏ đói thiên nhiên cho con người háu ăn yêu thiên nhiên”), tác giả liệt kê 3 trường hợp thương vong của cua tuyết, cá kình và cỏ biển. Những cái chết này đều đại diện cho tổn thất môi trường sống cũng như sự mất mát về đa dạng sinh học.
Learning From the Theory Crisis - UQ School of Education Postgraduate Research Conference Slides
Authors: Hennicke Ted
Published: October 2023

The broad aim of my PhD thesis has been to evaluate theories of irrationality, yet in the course of this work I have learned that many social sciences are undergoing a deep crisis of theory and validation (Oberauer & Lewandowsky, 2019), that parallels the more widely publicised replication crisis (Open Science Collaboration, 2015). This topic represents an interdisciplinary meeting place with significant implications for education. The aim of this sub-project of my thesis was to investigate the theory crisis and identify some best practices for moving forward with the hope of rectifying these structural issues within social sciences research. Using a narrative style literature review, I found that new methodologies and techniques have been created to address this issue, foremost among them Borsbooms’ (2021) Theory Construction Methodology (TCM). There are a number of exciting implications for fields such as education, but in the meantime it is important for researchers like myself merely to be aware of the issue and to heed Eronen & Bringmann’s (2021, p.785) call to action: we need to fully comprehend “the importance of having clearly and transparently defined concepts as the basis for theories”, and we need to do more phenomena detection research to better constrain theoretical models.
„…czy ona to zrozumie?” — język, komunikacja międzyludzka i międzygatunko‑ wa w powieści Barbary Gawryluk pt. Czarna, Klifka i tajemnice z dna morza
Authors: Zabawa Krystyna
Published: October 2023

In this article, Krystyna Zabawa analyses Barbara Gawryluk’s novel for older children Czarna, Klifka i tajemnice z dna morza [Czarna, Klifka and the secrets from the seabed] from the perspective of the commentaries this novel makes on language issues and on aspects of interpersonal as well as interspecies communication. Zabawa identifies the ways in which the novel presents foreign languages (Swedish and English) and how it encourages young readers to learn them. Zabawa interprets Gawryluk’s novel a text about communication problems and about the conditions necessary for mutual understanding among people. She also analyses passages in the novel that address human-animal and animal-animal communication.
Ekonomicheskoe razvitie kak faktor obespecheniia sotsial'noi spravedlivosti: prognoz i mery gosudarstvennogo vozdeistviia
Authors: Batievskaia Veronika Bogdanovna
Published: October 2023

The chapter provides a comparative description of the concepts of economic growth and economic justice, and proposes indicators that characterize them. A forecast of the dynamics of economic development indicators was constructed using the extrapolation method until 2027, which gave a steady downward trend in growth. To prevent negative trends in economic development, measures of government influence on the economy are proposed, which should be carried out in three stages: determining the goals of economic development; analysis of the strengths and weaknesses of socio-economic relations within the country, as well as threats and opportunities from foreign counterparties; implementation of existing advantages into active moves and the formation of new ones. It is concluded that the successful socio-economic development of Russia should lead it to the establishment of social justice. An analysis of various approaches to the definition of the concept of «social justice» is made.
The ratio of tradition and innovation in nutrition and food storage in the rural everyday life of Central Kazakhstan 1964–1985
Authors:   Karaganda University of the name of academician E.A. Buketov, Ybyraikhan M.Y. , Saktaganova Z. G.
Published: October 2023

The article discusses the definitions of the symbolic meaning of nutrition, its main characteristics, and the impact on the attitude to nutrition in the social environment. This study is based on archival documents and interviewing materials first introduced into scientific circulation. The authors of the article use comparative and microhistorical methods for studying the issues of nutrition and food storage in everyday life. Also, the authors describe the specifics of the natural environment, economic and living conditions of farms in the Central region of Kazakhstan and reveal the specifics of the technology of cooking and storing food based on national and regional characteristics. In the context of the introduction of technical innovations and/or their absence, changes in nutrition in the daily life of villagers are clarified. The influence of changes in the national composition in time and space on the domestic and economic situation is observed. Categories of the population of Central Kazakhstan are highlighted and the issues of sources, consumption and processing of food are considered systematically. As a result, the problems of preserving and changing centuries-old Kazakh traditions and technologies, national identity in various aspects of rural everyday life in Central Kazakhstan are identified. The authors conclude that the survival strategies of rural residents in conditions of mass scarcity are based on the preservation of traditions in the realities of life during the Soviet stagnant period.
Research of information culture of Kazakhstan secondary school students (on the example of Karaganda, Temirtau and Saran)
Authors:   Karaganda University of the name of academician E.A. Buketov, I.D. Khlebnikov , A.Zh. Myrzakhmetova ,   Karaganda University of the name of academician E.A. Buketov, N.K. Momosheva
Published: October 2023

This article discusses the results of the study on the information culture of Kazakhstan secondary school students. This study aims to assess the level of information culture of modern Kazakh youth, identify potential risks and threats, develop effective strategies and recommendations for the development of information literacy skills. The data of respondents of the categories “Students of secondary schools” (500 people), “Teachers of secondary schools” (500 people) and “Parents of students of secondary schools” (500 people) are analyzed. Based on the percentage distributions obtained by these categories of respondents, the analytical grouping of the obtained data was carried out under the hypotheses of the study and the analysis of the responses was carried out under the research program. The analysis of the systematized information made it possible to identify the positive and negative sides of the information culture of the main categories of respondents. In particular, the interviewed students have basic skills of working on the Internet, which is the most popular source of information for them. Most schoolchildren are confident in their information retrieval skills and do not demonstrate computer gaming addiction. Most teachers rate the student’s digital literacy, media literacy and information literacy skills highly. However, more than a third of the surveyed students spend over 6 hours a day on the Internet. Teenagers consider the network as an opportunity to communicate, have fun, relax and, to a lesser extent, study, but do not perceive it as a means to create financial, social capital, solidarity, and selfexpression.
Life and work of Shaimerden Kosshegulov
Authors:   L.N. Gumiliyov Eurasian National University, S. Zhumatay , S.K. Кabyltayeva
Published: October 2023

The national liberation movement of the second half of the nineteenth and early twentieth centuries covered the multifaceted social, cultural, political problems of the Kazakh society, and at the present stage, the issues of education, the national economic economy have not lost their relevance. During the years of independence, these issues acquire new meaning and content. The second half of the 19th–early 20th century particularly interests researchers. The development of capitalist relations in Russia led to great changes not only in the center of the country but also in all spheres of life on the colonial outskirts, in the state structure and culture. Under the influence of the objective laws of the new economic order, great changes took place in the public consciousness of the Kazakhs, and a national intelligentsia began to form. At the same time, the creation of a parliamentary system in Russia, the election of representatives of the Kazakh steppe as deputies to the 1st and 2nd Dumas contributed to the improvement of the political consciousness and experience of the national intelligentsia. The North-Eastern region of Kazakhstan developed under the influence of the political processes taking place in Russia. Local national representatives were involved in state-political processes. Sh. Kosshegulov was twice elected to the State Duma, in 1906, he participated in the All-Russian Muslim faction and in the development of its program, which is an event of great political significance. Sh. Kosshegulov conscientiously performed his work and did a lot of useful things to open the eyes and awaken the consciousness of the Kazakh people. Therefore, the article discusses the life and work of Sh. Kosshegulov in the socio-political, spiritual, and cultural development of Kazakhstan in the late nineteenth and early twentieth centuries.
Manifestations of existential experiences during the collapse of the USSR in Kazakh society
Authors:   Karaganda University of the name of academician E.A. Buketov, Balshikeyev S.B. , Sarsenbekov N.Zh. ,   L.N. Gumiliyov Eurasian National University
Published: October 2023

This article aims to study the existential experiences of citizens of Kazakhstan during the collapse of the USSR. Researchers on this topic have not conducted a philosophical analysis. The relevance of the chosen topic is primarily due to the fact that the consequences of this period on citizens, their psychology and worldview, which were formed by the existential experiences of that period, have not been fully studied. This political event brought not only new socio-economic conditions to the lives of ordinary citizens, but also existential experiences that are associated primarily with the loss of life guidelines and ideology. In the Republic of Kazakhstan, for an entire decade (the 90–80years), a type of personality was formed that did not meet the Western standard. Thus, the experience of this period largely determined the worldview and values. People have experienced existential anxiety from the realization of their own lives. This is the basis of social relationships, which form the core and ensure the building of higher symbolic personality. The dialectical method allowed us to analyze the formation of personal experience as a complex and rather contradictory process, in which there is a clash of existential and socio-cultural determinants of human existence. The method of typology enabled the classification of certain aspects of personal experience by assigning them to certain types of philosophical teachings. The method of comparative analysis facilitated to identify the similarities and differences between different types of philosophical discourses about the personality and the experience of its development. The method of hermeneutical analysis of texts helped to reveal their general semantic context, in relation to the interpretation of personal experience in various philosophical concepts.
Сulturological analysis of petroglyphs “The glory of the ancient Turks”, “Flag bearer”, and “The war of horsemen and foot archers” related to the culture of the ancient Turks in Kazakhstan
Authors:   Shakarim University of Semey, Tatiyev E.E.
Published: October 2023

Today, the creation of Cultural Studies in Kazakhstan is one of the most important tasks. One of the sources of culture in this field of science is spiritual and material values, the fundamental values of our knowledge. In this regard, the article considers petroglyphs of the ancient Turkic period – monuments of material values of history and culture. The ancient Turkic era is a powerful period of military hegemonic policy. Therefore, the article discusses and presents to the reader images of military scenes of that era in stone relief. The authors of the article, having conducted a scientific analysis of the material values of historical time, set the goal of how to implement it
Nuclear energy: security issues and geopolitical aspects
Authors:   al-Farabi Kazakh National University, Alipbayev A. , Byuzheyeva B. , Balaubayeva B. , Bulantayeva N.
Published: October 2023

n the modern world, energy is the basis for the development of fundamental industries that determine the progress of social production. Nuclear energy is one of the rational sources of energy in the energy sector. Nuclear power plays a constructive role in meeting the energy needs of the 21st century. To counter the challenges facing nuclear energy today, it is also paramount to identify security and geopolitics issues related to nuclear energy. At the same time, to explain fully the role of nuclear energy, develop a global partnership to coordinate political and technical factors, improve cooperation between governments and export controls at the global level, reduce risks during the operation of nuclear reactors, support nuclear research through investment mechanisms through public partnerships, stimulate safe, economical and reliable use of existing chains of nuclear reactors are among the topical issues. However, geopolitical factors and security issues limit the possibilities of nuclear energy. The article considers that new geopolitical forces, such as development and climate change, can also change the international approach in the interests of nuclear energy. The idea that the goals of global climate change may cause increased interest in nuclear energy, where there is no loss of carbon as a potential source of electricity, is not ignored. Safety issues and waste disposed of after being used as an energy source will also increase doubts about nuclear power. At the same time, the article examines the positive side of this nuclear energy in the history of world development and, in particular, the security situation, which pushes to define an approach to nuclear energy
The Kazakhs and the Siberian Khanate: Soviet Historiography of the Problem
Authors:   Institute of State History, Abil Ye. , Kuzembayuly A. ,   Kostanay Regional University named after A. Baitursynov
Published: October 2023

The article analyzes the representation of the place of the Kazakhs in the history of the Siberian Khanate in the Soviet historical science. One of the most interesting and discussed problems in the pre-colonial history of Western Siberia is the problem of the Kazakhs’ place in the history of the Siberian Khanate. On this issue various, sometimes diametrically opposite, points of view are expressed. The basic concepts have developed in the Russian pre-revolutionary science, but in Soviet time they have been considerably improved considering the achievements of ethnology, archeology, and source study. In the Soviet historiography of a problem, it is possible to allocate two basic directions on a question of a place of Kazakhs in the history of the Siberian Khanate. The first, dominant in the Soviet historical science, is the work of V. Ogorodnikov and S. Bakhrushin. According to it, the Kazakhs appeared on the borders of Western Siberia only at the end of the 17th — beginning of the 18th century and play an insignificant role in the history of the Siberian Khanate.The second, represented by the works of N. Tomilov and his followers, relates the Kazakhs to the number of autochthons of Western Siberia and active participants in the processes associated with the history of the Siberian Khanate.
Life fragments of Soviet citizens arrived from the PRC for the development of virgin lands
Authors:   Astana Medical University, Zh.S. Mazhitova , G.T. Isakhan ,   State Archive of the city of Nur-Sultan
Published: October 2023

Based on archival documents, the authors of the article examine the process of repatriation of Soviet citizens from the People’s Republic of China to the virgin lands of Kazakhstan in the 1950s. The study reveals the issues of labour and housing arrangements for immigrants, as well as measures of district authorities to implement the Resolution of the Secretariat of the Regional Committee of the Communist Party of Kazakhstan on the arrangement of citizens arriving from the PRC. Some repatriates who arrived for permanent residence were provided with housing by local authorities and became actively involved in agricultural and construction works. At the same time, the authors note that there were serious shortcomings in the material and domestic arrangements of the Soviet citizens arriving from the PRC. To solve those and other problems, the Agricultural Department of the CPSU Central Committee of the Union Republics sent responsible party and state officials to the Kazakh SSR. Together with the local regional and district authorities, they travelled to the areas where the repatriates were settled and compiled reports and memoranda on the real material and domestic situation of the repatriates. The comprehensive recommendations of the inspection bodies to solve the problems of returnees were voluminous and often difficult to implement. The authors conclude that the issues of housing and employment of repatriates from the PRC were not fully solved due to objective and subjective reasons.