bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticancer Screening of the Phytochemicals Present in the Medicinal Plant Vitex Negundo Against Mutant Anaplastic Lymphoma Kinase (ALK) Protein: An In-Silico Approach
Authors: Anusha D. , Sharanya S. , Ramya Ramya , David Darling Chellathai
Published: July 2019

The lymphomas are a heterogeneous group of cancer of the lymphocytes and the lymphatic system and accounts for up to 3% of all malignancies.1 Most of the drugs currently used for the treatment of lymphoma produce various side effects, hence in this study, we focus on natural compounds, obtained from the medicinal plant Vitex negundo, which exhibits selective toxicity against cancer cells. The objective of this research was to formulate the binding energies and interaction of selected phytochemicals present in the medicinal plant Vitex negundo2 against anaplastic lymphoma kinase protein, which is overexpressed in an anaplastic large cell lymphoma.3, 4,5 The structure of mutant human anaplastic lymphoma kinase protein was retrieved from the Protein Data Bank (PDB ID:4ANL ) and the 3D chemical structure of the phytochemicals present in the medicinal plant Vitex negundo was obtained from the PubChem database. Molecular docking study was performed for these natural compounds to evaluate and analyze their anti-lymphoma-cancer activity. A total of 16 compounds present in Vitex negundo, based on a comprehensive literature survey was selected for this molecular screening. Molecular docking analysis was carried out by Molegro Virtual Docker software, to screen the 16 chosen compounds and rank them according to their binding affinity towards the site of interaction of the oncoprotein, anaplastic lymphoma kinase. Out of the 16 screened phytocompounds, only 4 compounds showed promising interactions against the oncoprotein ALK (4ANL). 6’-p-hydroxybenzoyl mussaenosidic acid exhibited a very good binding with a molecular docking score of -127.723 kcal/mol, ranking first among the compounds screened. This was followed by Betulinic acid, Viridiflorol and protocatechuic acid with molecular docking scores of -95.596 kcal/mol, -76.1648 kcal/mol and -63.0854 kcal/mol and - respectively. The docking scores from the above study shows that the phytocompounds present in Vitex negundo extract exhibits an effective inhibitory effect against anaplastic lymphoma kinase protein that is over expressed in lymphoma.
ICRODI: Image Compression of Region of Diagnostics Interest (RODI) using Layer Segmentation and Wavelet
Authors: Vijaya S. M. , Suresh K.
Published: July 2019

Robotic guided medical system requires efficient mechanism of compression of Region of Diagnostics Interest (RODI) in medical images to overcome the tradeoff among efficiency and time which is a computationally challenging task. This task involves the requirement of suitable noise filtering, segmentation, critical feature selection especially at corners of RODI and encoding process. This paper proposes a framework namely ICRODI to evaluate a hybrid approach of compression for region of diagnostic interest in Brain MRI as well as for rest of the region. The approaches used are median filter, thresholding as pre-processing and fuzzy c-mean clustering, Harris corner detection, s-shape fuzzy for segmentation and feature point selection optimization. Further alpha hull of the convex hull is used for getting the volume of the mass and finally the wavelet co-efficient based compression is applied. The effectiveness of the proposed ICRODI is validated by evaluating MSE and PSNR for both RODI and Non-ROSI. The average value of the PSRN for RODI is found approximately 49 % higher as compared to the non-RODI and MSE of the RODI is reduced by approximately 33% as compared to the non-RODI after simulating the process on a numerical simulation platform. The achieved results are quite promising and could be optimized for the VLSI implementation in future.
The phagocytosis activity of isoeugenol-ester compound on Mus musculus macrophage cell
Authors: NURHAYATI AWIK PUJI DYAH , SANTOSO MARDI , SETIAWAN EDWIN , RACHMA DEAVINA THALITA
Published: July 2019

Abstract. Authors. 2019. The activity phagocytosis of isoeugenol-ester compound on Mus musculus macrophage cell. Nusantara Bioscience 11: 117-122. Chemotherapy is drugs therapy for cancer. However, chemotherapy could damage normal cells and decrease immune system. For this reason, it is necessary to find immunostimulant compound that is able to increase immune system. Isoeugenol-ester is unnatural compound that has been tested for its cytotoxicity against cancer cell and showed positive result. Nevertheless, ability of Isoeugenol-ester for inducing phagocytosis is still unknown. Therefore, bioassays study using in vitro phagocytosis were performed. Latex beads methods using antigen model in 5 isoeugenol-ester concentration series: 6, 25; 12, 5; 25; 50 and 100 μg/mL were tested to Mus musculus peritoneal macrophage cell. The optimum concentration of Isoeugenol-ester compounds in inducing phagocytosis activity of M. musculus macrophage cell was 12.5 μg/mL.
Shoot multiplication of Pogostemon cablin var. Sidikalang and patchouli oil profile
Authors: HARDJO POPY HARTATIE , SUSANTO DANNY PUTRA SENTOSA , SAVITRI WINA DIAN , PURWANTO MARIA GORETTI MARIANTI
Published: July 2019

Abstract. Hardjo PH, Susanto DPS, Savitri WD, Purwanto MGM. 2019. Shoot multiplication of Pogostemon cablin var. Sidikalang and patchouli oil profile. Nusantara Bioscience 11: 123-127. Pogostemon cablin Benth. is a plant producing patchouli oil, which mostly consists of patchouli alcohol compound. Patchouli oil has great potentials in the world market because of its stability and high price. In this study, in vitro multiplication of Sidikalang variety of Acehnese patchouli shoots was done on solid and liquid Murashige & Skoog (MS) medium. This study aimed to determine the effect of cytokinins in various combinations of shoot multiplication and to compare the patchouli oil yield of in vitro and ex vitro culture. In vitro multiplication of Acehnese patchouli shoots by using solid MS medium with addition of 0.2 ppm benzyl aminopurine (BAP) and 0.2 ppm Kinetin resulted in shoot explants with an average growth index of 82.198 ± 0.690. Patchouli oil extraction was done on 7 weeks old in vitro shoot explants cultured on solid MS medium + 0.2 ppm BAP + 0.2 ppm Kinetin using water distillation method. In vitro shoots yielded 2.5% patchouli oil and contained ± 35% patchouli alcohol compound, whereas ex vitro shoots produced 4% patchouli oil and contained ± 25% patchouli alcohol compound. The qualitative analysis by using thin layer chromatography (TLC) showed that there were similarities in the number of spot and Rf value for each spot of ex vitro and in vitro patchouli oil.
Antimicrobial properties of Chlorocardium rodiei on Pseudomonas aeruginosa, Bacillus spp. and Candida albicans
Authors: DAVID DENNIS , DANIEL RUTH , SEECHARRAN DIANA
Published: July 2019

Abstract. David D, Daniel R, Seecharran D, 2019. Antimicrobial properties of Chlorocardium rodiei on Pseudomonas aeruginosa, Bacillus spp. and Candida albicans. Nusantara Bioscience 11: 128-132. This research seeks to investigate the antimicrobial properties of Chlorocardium rodiei leaves and seeds on Pseudomonas aeruginosa, Bacillus spp. and Candida albicans. It also seeks to extract and identify the phytochemical compounds presented in leaves and seeds. The crude plant extract was obtained using the maceration method of extraction (ethanol and acetone as solvent) followed by rotary evaporation. Phytochemicals were analyzed from the crude extract using standard phytochemical procedures. 1%, 50% and 100% concentrations of each extract were prepared and used in the disk diffusion assay against C. albicans, P. aeruginosa, and Bacillus spp. and compared against Ciprofloxacin and Erythromycin for the bacteria and Fluconazole for the fungus. The results showed that the extract from the leaves possesses weak (≤12 mm) to moderate (>12 ≤15mm) inhibitory effect, while the extract from the seeds had weak (<12mm) inhibitory effect on the microorganisms. The phytochemical compounds tannins, essential oils, saponins, and phenols were tested positive from the crude extract. For the first time, the antimicrobial properties of C. rodiei’s leaves and seeds were evaluated and showed to possessed antimicrobial properties.
Comunicando en los nuevos entornos. El impacto de Twitter en la Comunicación Política española
Authors: Gelado-Marcos Roberto , Navío-Navarro Mariché , Rubira-García Rainer
Published: July 2019

El bipartidismo dominante durante décadas en España comenzó a quebrarse a partir de las Elecciones Europeas de 2014 y la tendencia se consolidó en los siguientes comicios, las Elecciones Autonómicas y Municipales de la campaña de 2015. Pese a todo, no se ha estudiado en profundidad el papel que tuvo la comunicación en nuevos soportes a la hora de explicar el cambio del panorama electoral. En otras palabras: ¿se adaptaron mejor los partidos emergentes a los nuevos entornos de comunicación para conectar con la ciudadanía? ¿Fueron las fuerzas que mejor usaron esta comunicación 2.0 las que más respaldo obtuvieron en las urnas? La presente comunicación aspira a arrojar luz sistemática sobre el uso de las redes sociales, en particular Twitter, dentro de las estrategias de comunicación política para el antedicho caso de estudio. Para ello se ha desarrollado una metodología que triangula entre la cuantificación de tweets por temáticas y una aproximación más cualitativa al análisis de sus contenidos que, a través del análisis lingüístico, permitan identificar patrones retóricos que arrojen luz a las preguntas de investigación anteriormente formuladas y, en última instancia, permitan constatar las hipótesis que quedan esbozadas como respuestas provisionales a aquellas preguntas.
Moralistic versus compassionate portrayals of prostitution in Moroccan cinema: the case of Casablanca by Night versus Much Loved
Authors: Cheikh Mériam , Peralta-García Lidia
Published: July 2019

En los medios de comunicación marroquíes, la figura de la prostituta ha pasado a ser un icono cultural. Este artículo analiza desde una perspectiva comparada dos formas diferentes de  representación en dos películas marroquíes: Casablanca by Night (Mostafa Darkaoui, 2003) y Much Loved (Nabyl Ayouch, 2016). En el primer caso la figura de la prostituta se corresponde con la idea hegemónica y moral que el gran público tiene sobre la prostitución en Marruecos. En el segundo caso se lleva a cabo un retrato extraído de la experiencia directa de las prostitutas. El principal objetivo de este artículo es definir temas prevalentes como el delito, la inmoralidad, la probreza, la enfermedad y la violencia, que normalmente se asocian con la prostitución en Marruecos a través de los medios de comunicación. Nuestro segundo objetivo es analizar como estos temas se despliegan de forma diferente en estas dos películas y porqué dieron lugar a una fuerte controversia social en el caso de la segunda. Argumentaremos que CBN utiliza “mecanismos de neutralización” de carácter cinematográfico y social. ML, por el contrario, adopta una perspectiva realista. A mayor nivel de realismo y de representación moderna de la prostitución, mayor nivel de controversia social y polarización.
Microwave Assisted Synthesis Polyaniline-Vanadium Oxide Nanocomposites and their Electrochemical Studies
Authors: Shivhare Sugam J. , Loharkar Praveen Kumar , Vyas Supriya
Published: July 2019

In this article, we reported microwave assisted processing of vanadium oxide-polyaniline nanocomposite (PANI/V2O5). Firstly, polyaniline (PANI) is synthesized by oxidative polymerization method and vanadium pentoxide nanoparticles. In the second step, intercalation of PANI in V2O5 framework are carried out in the microwave at 80 ºC for 30 min in Teflon crucibles. The XRD exhibited a set of well-defined peak support the crystal nature of nanocomposites. FTIR studies of the composite supported the intercalation of PANI with V2O5. The peaks obtained by cyclic voltammetry shows marginal separation between anodic peaks at 3.6 and 3.7 V for polyaniline and shifted to the higher potential for PANI/V2O5 nanocomposite. Also, the electrical conductivity is found to be 10-6 S cm-1 for PANI and higher electrical conductivity, 10-4 S cm-1 for nanocomposites.
Crystal Structures and Cytotoxicity of Four Silver(I)carboxylate Complexes with 1,2-Ethylenediamine Analogues
Authors: Xu Suo-Ping , Dong Qian
Published: July 2019

Four silver(I) compounds, [Ag(dapn)(dnbc)]n·1.5nH2O (1), [Ag(en)]n[Ag(dnbc)2]n·2nH2O (2), [Ag(en)]n[Ag(nbc)2]n·2nH2O (3) and [Ag(dapn)]n -(nbc)n·2nH2O (4), where dapn = 1,2-diaminopropane, dnbc = 3,5-dinitrobenzoate, en = 1,2-diaminoethane and nbc = 4-nitrobenzoate, have been synthesized and characterized by X-ray diffraction. The Ag(I) ions show T-shaped coordination geometry in compound 1 but linear coordination geometry in compounds 2, 3 and 4. There are ligand-unsupported Ag…Ag interaction in compounds 2 and 3 with Ag…Ag distance of 3.177 ~3.267 Å. All the four complexes showed high cytotoxicity properties.
Synthesis and Antimicrobial Activity of Azobenzene Based Titania Nanoparticles Coated Cotton Fibers
Authors: Sharma Mamta , Tomar S.S.
Published: July 2019

In this paper, we report the synthesis of a highly photocatalytic titanium dioxide nanoparticles bondedwith azobenzene and cotton by simple sol-gel method. The synthesized azobenzene based titania nanoparticles coated cotton fibers were characterized using UV-visible and SEM and reported their antimicrobial activity. It was observed that the presence of titanium dioxide bonded with azobenzene effectively prevents both the cotton fibers from getting contaminated.
Synthesis of Fabricated Polyurethane Matrix Based TiO2–HAp Material
Authors: Sharma Mamta , Tomar S.S.
Published: July 2019

In this research work, the composition of polyurethane, titanium di oxide and hydroxyapatite were optimized to obtain a stable polymer nanocomposite microfilm with excellent flexibility and durability, through simple sol-gel synthetic method. The obtained films were further cut by nesting and formed to obtain a flawless stent structure with desirable mechanical, biocompatibility and drug delivery properties. XRD, FTIR, SEM characterizations were performed to study their physical, chemical and biocompatible properties. The tensometer tests, simulated body fluid tests and blood interaction tests showed competitive results that match the properties of conventional materials such as metals and alloys.
Designing of Nitroimidazole Derivatives as a Promising Target for Treatment of Tuberculosis
Authors: Kakadiya Monika , Ramiya Singh , Noolvi Malleshappa , Pasha T.Y.
Published: July 2019

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, with high level of mortality worldwide, currently with approximately 10 million cases of tuberculosis. These rate of incidence are due to several factors such as bacterial resistance, AIDS, latent tuberculosis that reoccur in patient. Deazaflavin dependent nitroreductase (Ddn) is an emerging target in the field of antitubercular agent. Ddn catalyses the reduction of nitroimidazoles resulting in intra-cellular release of lethal reactive nitrogen species. Nitroimidazole class drug- delamanid and pretonamid are used in the treatment of MDR-TB. In this present study, 26 new nitroimidazole derivatives were designed and docked into Ddn enzyme. In docking study, compounds 3, 5, 15, 16, 17, 18 and 21 showed similar interaction with amino acid residues such as Tyr 65, Ser 78, Tyr 136 as pretonamid reference drug and highest docking score and better ADMET compatibility. The ADMET prediction docking study of new designed compound revealed that the compounds 3, 16, 17 and 21 showed good binding with Ddn. In future it may be good and effective lead for development of antitubercular agent.
Synthesis and Antifungal Activity of New Dihydropyrazoles of Designed Curcumin Analogues
Authors: Tripathi Vishwa Deepak , Saxena Nisha
Published: July 2019

A library of new dihydropyrazole derivatives have been synthesized from well designed curcumin analogues by reaction of chalcone derivatives with phenylhydrazine. All the synthesized compounds were characterized by spectroscopic (1H and 13C NMR, IR spectra), spectrometric (Mass spectra) data and elemental analysis. Dihydro-pyrazoles exhibited characteristic dd (double doublet) due to presence of optically active carbon of pyrazole ring. All the synthesized compounds were also evaluated for their antifungal potential against six different fungal starins. Evaluated heterocyles showed potent inhibitory property against tested fungal strains with minimum inhibitory concentration (MIC) values upto 3.12 μg/mL. Heterocyles with nitro and methoxy substitutions were showing best antifungal activities. Among 20 different derivatives tested for biological activity SAR has been developed between the various substitutions at phenyl ring of synthesized heterocycles.
Formulation Development and Characterization of Rilpivirine Nanosuspension for Improved Solubility by Nanomilling
Authors: Sahoo Satya Sankar , Rao Chandu Babu
Published: July 2019

The objective of this study was to formulate and optimize a stable rilpivirine nanosuspension. In the present study, yttrium stabilized zirconium oxide beads being used as the milling media in nanomilling process. The lyophilized nanocrystals were being characterized by particle size distribution (PSD), polydispersity index (PDI), X-ray diffraction (XRD) and FTIR (Fourier transform infrared spectroscopy). Optimized nanosuspension has mean particle diameter of 266 nm, PDI of 0.158, zeta potential of 22.1 mV and spherical in shape with surface oriented stabilizer molecules. Flow properties like sedimentation volume, poura-bility with the F value of 0.94 and also the redispersability even after 4 weeks of storage was found to be satisfactory for the optimized nano-suspension. Many folds increase in solubility and rate of drug release observed, The lyophilized nanocrystals retains its crystallinity after nanomilling, stable chemically with high drug content, therefore, the developed nanosuspension would be an alternative better formulation than its conventional formulation to address its bioavailability issue. However, this should be further confirmed by appropriate techniques in vivo studies.
DETERMINATION OF THE CONTENT OF XANTONS AND THE ELEMENTAL COMPOSITION OF THE SUPERTHE EARTH AND EXTRACT IRIS LACTEA PALL
Authors: Antipova Ekaterina Alekseevna , Leites Elena Anatolyevna
Published: July 2019

Iris lactea Pall (milky-white iris) belongs to the genus Iris L. of the Corridaceae family Iridaceae. In the form of an herb or an extract of Iris lactea Pall is found in some dietary supplements, it is included in the Alpizarin ointment, used as an antiviral agent. The use of antiviral drugs of plant origin is the safest method of treatment, given that about 90% of the population is affected by herpes. Data on the elemental composition of herbs and extracts of Iris lactea Pall are absent in the literature.

The purpose of the work is to determine the content of xanthones and the elemental composition of the herb and the dry extract of Iris lactea Pall.

The article presents the results of the determination of the main groups of active substances. The quantitative content of Cu, Fe, Ca, Co, Ti, Se, V, P, B, Na, Mg, K, Al, Ba, Sb, Ag, Sr, Sn, Mo, was determined by the method of atomic emission spectrometry with an ionically coupled plasma. Ni, Cd, Pb, As, Zn, Be, Mn, Cr, while the content of heavy metals and arsenic in the grass and extract does not exceed their maximum allowable content in medicinal herbal preparations. The following methods were determined by thin layer chromatography: Xanthone alpizarin and flavonoids rutin and quercetin. The method of high performance liquid chromatography (HPLC) revealed the presence of alpizarin and related xanthones.

According to the developed method for the determination of xanthones by the HPLC method proposed in this article, the highest content of xanthones, in terms of alpizarin, is in the grass milky white – 1.14%, and in the dry extract – 1.79%.

Milk-White Iris extract and herb are a promising source for the development of drugs that suppress the reproduction of the herpes simplex virus and its subtypes.
STUDY OF THE INFLUENCE OF TEMPERATURE AND pН LEVEL ON PROPETIES OF COLLOIDAL SOLUTIONS OF ZnSe AND CdSe QUANTUM DOTS IN THE SHELL OF CHITOSAN
Authors: Beznosyuk Sergey Aleksandrovich , Shtobbe Irina Andreevna , Novikova Anna Sergeyevna
Published: July 2019

In this paper, we present a technique for the synthesis of colloidal quantum dots ZnSe and CdSe in an aqueous medium stabilized with a solution of chitosan at different pH values, and also studies of the properties of the resulting solutions as a function of temperature and acidity of the medium. It has been established that as the pH is increased in the region of 4.50−5.45, the amount of light transmission of colloidal solutions of quantum dots in the shell of chitosan increases, both in the case of zinc selenide and in the case of cadmium selenide. The effect of the medium acidity on the kinematic viscosity of the colloidal obtained solutions was studied. It has been established that the kinematic viscosity of colloidal solutions of ZnSe and CdSe quantum dots decreases with increasing pH of the medium in the region of 4.50−5.45: in both cases, there is a sharp drop in the kinematic viscosity in the region of 4.50–4.75 and a smoother decrease in the range of 4.75–5.25. It is shown that the stabilizing effect of chitosan in colloidal solutions of semiconductor nanoparticles depends on the temperature. The most stable in time are colloidal solutions prepared at a temperature of 35, 40 and 45 °C, in which the decrease in the light transmission in time was the smallest. Solutions synthesized at temperature 25 °С, as well as at higher temperatures (35, 40, 45 и 70 °С), did not show strong aggregative stability.
PHENOLIC COMPOUNDS VACCINIUM VITIS-IDAEA AND THEIR RESPONSE TO THE INFLUENCE OF VARIOUS ENVIRONMENTAL FACTORS
Authors: Artemkina Natal'ya Aleksandrovna
Published: July 2019

Cowberry (Vaccinium vitis-idaea L.) is one of the dominants of the herbaceous-shrubby layer of the forest vegetation of the Kola Peninsula. Plays an important role in the involvement of nutrients cycle, as well in the formation of soil fertility due to the ability to synthesize a large number of phenolic compounds, especially condensed tannins. Some regularities of changing the content in phenolic compounds, flavonoids and lignin in various tissues of Vaccinium vitis-idaea growing under industrial air pollution conditions have been studied. It was found that the concentration of lignin in mature leaves Vaccinium vitis-idaea decrease when approaching the source of pollution in spruce and pine forests. Biogeocenosis and age influence factors on the chemical leaves composition Vaccinium vitis-idaea have been revealed. Cowberry accumulates phenolic compounds, including tannins, in the leaves of older age classes. Concentrations of cellulose and lignin are decreased in perennial (mature) leaves. As the result of investigation, the phenolic compounds are proved to play the significant role in Vaccinium vitis-idaea adaptation to the influence of abiotic and biotic environmental factors. Phenolic compounds, flavonoids and lignin of Vaccinium vitis-idaea leaves behave differently under conditions of air pollution of different intensity.
THE TECHNOLOGY OF OBTAINING OF A SUBSTANCE FROM THE WASTE OF PROCESSING OF THE HYPERICUM PERFORATUM GRASS, WHICH POCESS OF GROWTH-STIMULATING ACTIVITY
Authors: Abdurakhmanov Bahtiyar Alimzhonovich , Turayeva Saida Muratova , Ibragimov Timur Farkhadovich , Khalilov Ravshanzhon Muratdzhanovich
Published: July 2019

The stage of drying of the mother liquor after extraction of flavonoids by ethyl acetate of the substance "Dry extract of Hypericum perforatum " was developed, on the basis of this the preparation "Zversin" with growth-stimulating activity was developed. It was found that drying of the "Zversin" using a spray dryer is optimal. As a result of the study of the influencing parameters on the drying process, the following mode was selected, which ensures the optimum operation of the dryer with a high yield of the final product: the temperature of the heat-transfer at the inlet of 160–170 °C, the outlet of 60–70 °C, the feed rate of the solution is 5.5 l / h∙m3, the dry residue of the solution is 10-15%.

The influence of the "Zversin" to the germination of seeds, the growth and development of plant seedlings has been studied. On the basis of the obtained results, the technology for the complex processing of St. John's wort has been developed, which allows to obtain substances for the treatment of depressive conditions and plant growth regulator. At the test technology, it was found that the yield of dry extract (content of total hypericins is 0.3%) yielded to 2.0%, "Zversin" (rutoside content is 6%) – yielded to 7% to the weight mass of raw material.
FLAVONOLGLYCOSIDE OF SOME SIBERIAN SPECIES OF THE SECTION XIPHIDIUM BUNGE OF THE GENUS ASTRAGALUS L.
Authors: Kotsupiy Ol'ga Viktorovna , Shemetova Tat'yana Aleksandrovna , Petruk Anastasiya Andreyevna
Published: July 2019

For the first time, the composition and content of flavonolglycosides was studied by high-performance liquid chromatography (HPLC) and a chromatograms of extracts of leaves of plants of the species of the Xiphidium Bunge section of the genus Astragalus L. Siberia was compared. The leaves of five species were investigated: A. ionae Palibin, A. lenensis Shemetova, Schaulo et Lomon., A. macroceras C. A. Meyer, A. palibinii Polozhij, A. stenoceras C. A. Meyer. There were found 9 main components, among them flavonols isoqurcitrin, rutin and astragalin have been identified. Glycosides G1, G2, G6 and isoquercitrin was found in all species, astragalin there is only in A. macroceras. Rutin not detected in A. stenoceras. The amount of the main glycosides of flavonoids in the leaves of plants in the species A. ionae, A. lenensis and A. palibinii varies between 0.26–0.70%, in A. macroceras – 0.37–0.59%, in A. stenoceras – 0.20% by weight of the absolutely dry raw material. The composition of the components on chromatograms confirms the taxonomic similarity between A. ionae–A. lenensis–A. palibinii. The chromatograms of A. macroceras and A. stenoceras have a large number of common components, however, composition the most abundant is noted in the A. macroceras.
THE EFFECT OF THE ENERGY PROCESS ON THE CHEMICAL COMPOSITION OF PLANT RAW MATERIAL OB-TAINED FROM LEAVES OF THE ASPEN OF THE GENERAL
Authors: Nekhorosheva Aleksandra Viktorovna , Nekhoroshev Sergey Viktorovich , Drenin Aleksey Anatol'yevich , Botirov Erkin Hozhiakbirovich , Gornikov Nikolay Viktorovich , Zotova Anzhela Mikhaylovna , Krasil'nikov Ivan Arkad'yevich
Published: July 2019

The analysis of the chemical composition of the vegetable raw materials received from leaves of an aspen ordinary, family plants Willow (Salicaceae), growing in the territory of the Khanty-Mansi autonomous district Yugra is provided in article. The choice of raw materials is caused by a large supply and fast reproducibility of a raw resource. In work numerical indicators and indicators of high quality of raw materials are established (humidity, the general ashes, sulphatic ashes, ashes not soluble in 10% to hydrochloric acid, extractive substances). The way of extraction of vegetable raw materials is reasonable, the comparative characteristic of content of extractive substances is provided in the received extracts. It is shown that the average content of extractive substances in native samples is 27.9%, the content of polysaccharides – 10.9%. The qualitative and quantitative analysis of biologically active agents is carried out by method of a highly effective liquid chromatography. The dominating components in samples of the plants growing in the territory of one land plot are салицин 510 mg of %, гиперозид 170 mg of %, routines of 210 mg of %. Influence of process of fermentation on the chemical composition of the vegetable raw materials received from leaves of an aspen ordinary is studied. The greatest exit of phenolic connections at impact on vegetable raw materials of fermentation is established by cold. The positive effect of impact of fermentation by crushing on quantity of the identified biologically active components is defined. Work was carried out for assessment of phytochemical parameters of quality of vegetable raw materials and formation of justification of analytical approaches to diagnostics of vegetable raw materials of the explored territory.
STUDY OF PHYSICAL-MECHANICAL PROPERTIES OF CHEMICAL-THERMOMECHANICAL MASS FROM WOOD OF THE POPLING
Authors: Koverninskij Ivan Nikolaevich
Published: July 2019

The article provides material on the study of chemical-thermomechanical pulp (CTMM) from poplar wood, produced by the Chinese company WeifangderuibioloDgical TECHNOLODGY CO., LTD. As a result of the research, it was established that CTMP of poplar wood has the ability to be easily milled with a significant increase (by 30–80%) of physical and mechanical properties. The interval of the possible degree of grinding, in which the mass can be used with the greatest efficiency, is recommended 30–50 °SR.

CTMM in unbleached form is a high-quality primary semi-finished fibrous material that can be effectively used in combination with waste fiber for the production of corrugated paper and cardboard for flat layers of corrugated cardboard (test liner). Adding weight to the composition is appropriate in the range of 20–50%.

CTMM in bleached form is a high-quality primary fiber for the production of base paper for various sanitary purposes. Compositions with bleached cellulose, in which cellulose should be added within 15–20%, will differ in high efficiency in imparting properties to paper.

When using coniferous sapwood (pine, larch), a characteristic large-tonnage waste of Russian enterprises, an increase in the mechanical properties of the mass is expected by 20–30%. Such a mass will be a significant factor in the development of the production of containerboard, sanitary and hygienic, as well as other types of paper and cardboard.

The CTMM technology offered by the Chinese company WeifangderuibioloDgical TECHNOLODGY CO., LTD is recommended for use by Russian timber merchants. In terms of its importance, the technology is capable of solving the tasks of developing the production of pulp, paper and cardboard, provided for in the Strategy for the Development of the Forest Complex of Russia until 2030.
ISOLATION AND STUDY OF PHYSICAL-CHEMICAL PROPERTIES OF GALACTOMANNANS FROM PLANT MA-TERIALS
Authors: Azimova Luiza Bakhtiyarovna , Normakhamatov Nodaliy Sohbalalievich , Khaytmetova Saida Bokizhonovna , Muhitdinov Bakhtiyor Ikromovich , Amonova Dilnoza Mukhtorovna , Filatova Al'bina Vasil'yevna , Khalilova Gulnoza Abduvakhobovna , Kirgizbaev Husniddin Hasanbaevich , Turaev Abbaskhan Sabirkhanovich
Published: July 2019

The aim of the study is isolation of galactomannan from plant materials and investigation of their physical and chemical properties. Polysaccharides generally consisting of galactomannan were isolated and purified from galactomannans from these eds the plants Sophora japonica and Gleditsia triacanthos by cold and hot extraction methods. Galactose and mannose contents of the galactomannans isolated were quantitatively characterized and physical and chemical properties of the polysaccharides were studied. In addition, polysaccharides isolated were enzymatic hydrolyzed and changes in the monosaccharide composition in the hydrolysis process were studied. The characteristic viscosities of the initial and hydrolyzed galactomannans were 4.85–3.80 dl/g, respectively. Molecular weights of the galactomannans, after treatment with the enzyme, changed in a range of 55600–26200 Da. Studies with 1H NMR and 13CNMR spectroscopy methods showed decreases in galactoside content of the hydrolyzed galactomannans, indicating the primary course of hydrolysis occurs by the side chain of the macromolecule. Increase in duration of enzymatic hydrolysis more than 24 hours led to the formation of poly-mannans with a minor content of galactose units. The obtained data can serve to improve isolation and preparation of galactomannan based materials for biomedical purposes.
THE KINETICS OF THE COMBINED PROCESSES OF DISPERSION AND EXTRACTION OF HUMIC AND FULVIC ACIDS FROM PEAT AND VERMICOMPOST IN THE ROTOR-STATOR DEVICE
Authors: Promtov Maksim Aleksandrovich , Stepanov Andrey Yur'yevich
Published: July 2019

Was conducted an experimental study of dispersion of solid particles, extraction of humic acids (HA) and fullview acids (FA) in suspensions of peat and vermicompost with repeated mechanical and hydrodynamic treatment in a rotor-stator device (RSD). According to reduce the average particle size and increase the concentration of HA and FA in suspensions of peat and vermicompost on the number of cycles in the RSD have an exponential character. The average particle size in suspensions of peat and vermicompost decreases from average size of 1 mm to 30 µm at 40 times the treatment of the suspension in the RSD. The intensity of the mass transfer of target substances from the solid phase to the liquid phase is due to an increase in the contact area of the phases, the value of which depends not only on the surface area of the solid particles, but significantly increases due to the opening of new pores and capillaries during particle grinding. The concentration of water-soluble HA in 25% peat suspension reaches 20 g/l, the concentration of FA – 6 g/l. The concentration of water-soluble HA in 25% vermicompost suspension reaches 12 g/l. Extractable substances on the surface of the particle and in the pores close to the surface, pass into the solution mainly during the first 10 treatment cycles. Effective diffusion coefficients and empirical coefficients of the kinetic equation for the extraction process of HA and FA in peat and vermicompost suspensions during their processing in RSD were determined.
COMPOSITION OF ESSENTIAL OIL OF ARTEMISIA MACROCEPHALA JACQUE EX BESSER GROWING IN MONGO-LIA
Authors: Zhigzhitzhapova Svetlana Vasil'yevna , Sambuunyam Sambuunyam , Randalova Tuyana Erdemovna , Radnaeva Larisa Dorzhiyevna
Published: July 2019

Сomposition of the essential oils of the plant Artemisia macrocephala, growштп in the central (aimak Arkhangai), northeastern (aimak Khentii) parts of Mongolia and compared with literature data are presented  in this paper. Essential oil was obtained by hydrodistillation method from dried aerial parts of plants.  Gas chromatography (GC) analyses was performed on an Agilent Technologies 6890 gas chromatograph equipped with quadrupole mass selective detector HP 5973  (MS) and an HP-5MS capillary column (30 m × 0.25 mm × 0.2 μm). 

Dark-blue essential oil was isolated from the aerial part of the plant.  Chamazulene (7.4-16.1%) and α-bisabolol (3.4-20.7) are  main components of essential oil of  Artemisia macrocephala , are which indicates the promise of using this species  as a raw material for the isolation of essential oil with anti-inflammatory, bactericidal , regenerative properties. Oil are characterized by a significant content  (sum 20–28.9%) of derivatives of nerol (neryl-2-methylbutanoate, neryl-3-methylbutanoate, nerylpentanoat) and its isomer of  geraniol (geranyl-2-methylbutanoate, geranyl-3-methylbutanoate). Six compounds (1,8-cineol, terpineol-4, α-terpineol, β-celinene, T-cadinol, methyl isocostate) are also constant for the studied samples. Comparison with the literature data shows that the compositions of essential oils of Artemisia macrocephala of  mongolian and russian (siberian) flora are close.
INHIBITION OF PHOSPHATIDYLCHOLINE LIPOSOMES OXIDATION BY PHENOLIC COMPOUNDS OF ALOE EXTRACTS: A. ARBORESCENS, A. PILLANSII AND A. SQUARROSA
Authors: Sazhina Natalia Nikolaevna , Lapshin Petr Vladimirovich , Zagoskina Natal'ya Viktorovna , Palmina Nadezhda Pavlovna
Published: July 2019

Various species of the genus Aloe which there are in the world more than 500 are considered as important sources of biologically active substances and attract an attention of researchers by numerous manifestations of their biological properties. The most studied and used Aloe species are A. arborescens and A. vera, however some other species show not smaller biological activity, in particular antioxidant, than made mention. In the present work on model of the initiated oxidation of phosphatidylcholine liposomes comparison of the antioxidant activity (AOA) of leaves extracts of A. arborescens, A. pillansii, A. squarrosa and also the total content of their phenolic compounds was carried out. It is established that A. pillansii extract has approximately by 12 times higher AOA, than A. arborescens extract, and by 4 times, than A. squarrosa. The measured values of the total phenolic compounds content showed considerably smaller difference between these extracts. It can demonstrate existence in A. pillansii leaves of more difficult antioxidant profile, than in A. arborescens, and higher concentration of active phenolic metabolites. Results of this work allow recommending A. pillansii for more depth studies of its different biological activities.
Contemporary Challenges for the Working Class and Peasantry in Brazil
Authors: Stedile João Pedro
Published: July 2019

In Brazil, there have been two recent parliamentary coups against the Workers' Party and in favor of banks and corporations. Dilma Rousseff was impeached in 2016 and Luiz Inácio Lula da Silva was prevented from running for president, sequestered, and imprisoned. The electoral coups have resulted in a government without a social base in most of Brazilian society. It does not have a project for the majority or for the nation. It is just a project for international capital, dominated by banks and global corporations. This has led to a government made up of many nuclei of power that, despite internal contradictions, remain in agreement as a unit with regard to the project of capital.
MARKA FAYDASININ MARKA TUTUMU VE SATIN ALMA NİYETİ ÜZERİNDEKİ ETKİLERİ
Authors: YILDIZ Erkan
Published: July 2019

Bu çalışmada marka faydasının; fonksiyonel, deneyimsel ve sembolik faydalarının marka tutumuna, marka tutumunun da satın alma niyetine olan etkileri araştırılmıştır. Aynı zamanda marka faydası boyutlarının marka tutumu üzerinden satın alma niyetine olan dolaylı etkilerine bakılmıştır. Bu araştırmanın evrenini Vakko ve Beymen markaları ürünleri satın alan tüketiciler oluşturmaktadır. Veriler kolayda örnekleme tekniği ile anlık olarak toplanmıştır. Anket uygulaması 1 Haziran – 30 Temmuz 2018 tarihleri arasında gerçekleştirilmiş ve kullanılabilir 400 veri elde edilmiştir. Araştırma modelinin analizinden önce araştırmada yer alan yapıların geçerlik ve güvenirlik çalışmaları gerçekleştirilmiştir. Geçerlik ve güvenirlik çalışmaları kapsamında; iç tutarlılık güvenirliği, birleşme geçerliği ve ayrışma geçerliği değerlendirilmiştir. Araştırma modelinin analiz edilmesinde kısmi en küçük kareler yol analizi (PLS-SEM) kullanılmıştır. Veriler SmartPLS 3.2.8 istatistik programı kullanılarak analiz edilmiştir. Araştırma modeline ilişkin; doğrusallık, yol katsayıları, R2 ve etki büyüklüğünü (f2) hesaplamak için PLS algoritması; tahmin gücünü (Q2) hesaplamak için de Blindfolding analizi çalıştırılmıştır. PLS yol katsayılarının anlamlılıklarını değerlendirmek için yeniden örnekleme (bootstrapping) ile örneklemden 5000 alt örneklem alarak t-değerleri hesaplanmıştır. Araştırma sonuçlarına göre; fonksiyonel, deneyimsel ve sembolik faydaların marka tutumu, marka tutumunun da satın alma niyeti üzerinde anlamlı etkileri olduğu anlaşılmıştır. Aynı zamanda fonksiyonel, deneyimsel ve sembolik faydaların da marka tutumu üzerinden satın alma niyetini dolaylı olarak etkilediği tespit edilmiştir. Modele ait R2 değerleri incelendiğinde marka tutumunun %66, satın alma niyetinin de %50 oranında açıklandığı tespit edilmiştir.
NOMOFOBİ ÜZERİNE BİR ARAŞTIRMA: ÜNİVERSİTE ÖĞRENCİLERİ ÖRNEĞİ
Authors: ÖZGÜR GÜLER Ebru , VEYSİKARANİ Dilek
Published: July 2019

Teknolojinin hızlı gelişmesinin sonucu insanoğlunun yaşam tarzı değişmiş, teknolojik cihazlar temel gereklilik haline gelmiştir. Akıllı cep telefonlarının aşırı ve kontrolsüz kullanımı sonucunda, mobil çağın yeni fobisi olarak kabul edilen mobil telefondan mahrum kalma ya da cep telefonu üzerinden iletişimden kopma korkusu olarak ifade edilen Nomofobi kavramı ortaya çıkmıştır. Araştırmalarda, Nomofobik özellikler gösteren bireylerin, sanal ortamdan vazgeçemedikleri bu nedenle günlük rutin işlerini genel olarak aksattıkları ayrıca sanal ortama ayırdıkları zamanı da kontrol edemedikleri ortaya çıkmıştır. Akıllı cep telefonları, üniversite öğrencilerinin hayatında önemli bir yer tutmaktadır. Bu bağlamda çalışmada, üniversite öğrencilerinin akıllı cep telefonuna olan bağımlılıklarını ifade eden nomofobi ölçeğinin alt boyutları belirlenmek istenmiştir. Araştırma, yüz yüze anket yöntemi ile uygulanmış ve çalışmaya 134’ü erkek ve 186’sı kız olmak üzere toplam 320 öğrenci dahil edilmiştir. Yapılan faktör analizi sonucunda “Çevrimiçi Olamama”, “Cihazdan Yoksunluk”, “İletişim Kaybetme” ve “Bilgiye Ulaşamama” şeklinde 4 alt boyut elde edilmiştir.
Peculiarities of changes in the sagittal balance of the cervical spine in cervicobrachial syndrome
Authors: Damdinov B. B. , Sorokovikov V. A. , Larionov S. N. , Koshkareva Z. V. , Sklyarenko O. V. , Zhivotenko A. P. , Kiriyenko A. N.
Published: July 2019

Objective. To analyze clinical manifestations of cervicobrachial syndrome and identify their relationship with sagittal imbalance using data of MRI and radiological examination.

Material and Methods. Clinical manifestations of cervicobrachial syndrome associated with degenerative changes in the spine were studied in 22 patients. Clinical examination, radiography of the cervical spine, electroneuromyography of the upper extremities, and MRI study were performed. The intensity of the pain syndrome was assessed by VAS, and the quality of life – by the NDI questionnaire. The sagittal balance of the cervical spine was evaluated according to the following characteristics: angle of T1 slope, atlantoaxial (C1–C2) angle, degree of shift of the center of gravity of C2–C7, and Cobb angle.

Results. The pain intensity in cervicobrachial syndrome correlates with sagittal balance changes in the C2–C7 Cobb angle (r = 0.656; p < 0.05), the angle of T1 vertebra slope (r = 0.520; p < 0.05), and in the degree of shift of the center of gravity of C2–C7 (r = 0.756; p < 0.02). Differences between MRI and radiological results of the sagittal balance measurement are not significant (p < 0.04).

Conclusion. The study of the sagittal balance can be included in the algorithm for diagnosing osteochondrosis of the cervical spine. The MRI, along with spondylography, can be used to assess the state of sagittal balance. Understanding the identified relationships can help in determining the program of etiopathogenetic treatment of patients with cervicobrachial syndrome with obligatory including the sagittal balance correction in the program.
Biostratigraphically Important Findings of Two Index Trilobites from the Jince Formation (Cambrian, Drumian) of the Příbram-Jince Basin (Barrandian Area, Czech Republic)
Authors: Knížek František , Vokáč Václav , Hartl František , Pavlovič Miroslav
Published: July 2019

Litavkaspis rejkovicensis Fatka, Kordule et Šnajdr from the Příbram-Jince Basin has been known to occur in a roughly 30 m thick eponymous Taxon-range Zone situated in the lower parts of the Jince Formation (Cambrian, Drumian), within the Eccaparadoxides pusillus Interval Zone. A unique finding of a cranidium of Litavkaspis sp. at the locality Jince-Vystrkov, described in this report, comes from the middle parts of the Paradoxides gracilis Taxon-range Zone, lying roughly 250 m higher than the hitherto known biostratigraphically youngest occurrence of the index taxon. Specimens of Dawsonia bohemica (Šnajdr) from the Jince Formation have been collected exclusively in about 1 m thick deposits of the eponymous Taxon-range Zone situated stratigraphically at the base of the Onymagnostus hybridus Interval Zone. The findings of Dawsonia cf. bohemica presented herein come from the localities Rejkovice – Potůček in the Litavkaspis rejkovicensis Taxon-range Zone, and Rejkovice – Ve žlutých in the Acadolenus snajdri Interval Zone. Their stratigraphic positions are therefore 30–50 m lower than the typical occurrence of Dawsonia bohemica (Šnajdr) in the eponymous Taxon-range Zone.
Lingulate Brachiopods of Tremadocian Age from the Abandoned Gabriela Mine (Krušná Hora, Central Bohemia, Czech Republic)
Authors: Mergl Michal
Published: July 2019

Lingulate brachiopods are described from a lithic sandstone referred to the upper part of the Třenice Formation. Loose blocks were sampled from a dump of abandoned Gabriela Mine in Krušná Hora Hill near Beroun, Central Bohemia. Apart of the Acrotreta aff. grandis Klouček, 1919, genera Teneobolus, Rosobolus, Broeggeria, Rowellella and Siphonobolus are distinguished. Comments to their ontogeny, affinity, stratigraphical and spatial occurrences and taphonomy are discussed.
Golden hoard found in Prague-Josefov, U starého hřbitova No. 248. Notes to finds of ducats from the pre-Jagiellon period in Prague
Authors: Polanský Luboš , Budaj Marek
Published: July 2019

The hoard was discovered before Christmas in 1928 during additional demolition of the foundations of the Jewish hospital, under its foundations, very close to the Jewish cemetery in Prague-Josefov. It used to consist of at least 33 gold coins in a clay bowl. Thirty two coins are represented by the Hungarian ducats struck under Sigismund I of Luxembourg (1387–1437) in Buda (18 pcs), Kremnice (Kremnitz, 7 pcs), Košice (Cassovia, 6 pcs) and Velká Baňa (Nagybánya, 1 pc) before 1430, and one coin is English noble struck under Edward III (1327–1377) in Calais. The hoard is one of three known hoards from Prague with gold issues dating back to the pre-Jagiellon period. It was hidden under the wall of the building in place where the Jewish settlement expanded. The owners of the house – of various origins – changed quickly, and since 1440, the building has been owned continuously by the Jewish community. In time of the burial of the hoard, the house was very likely owned by the Prague brewmaster called Hanuško from Prague (1418–1429/1431, 1440) or by the saddler called Václav Paznehtík (1429/1431–before 1433). The hoard was not reported by the finders, the police detected them soon, and they were brought to the court and sentenced to jail. The National Museum bought the part of the hoard for the numismatic collection in 1930.
Bohemian coins of the 15th and the beginning of the 16th centuries found in Budislavice
Authors: Ryant Jiří
Published: July 2019

Six Bohemian silver coins described here come from the inheritance of Jiří Sedmík from Prague (1898–1942), a collector and important Czechoslovak diplomat, who participated in the anti-Nazi resistance. He was arrested in 1940 and executed in Berlin-Plötzensee at the end of 1942. Based on previously published data, some 70 Bohemian pieces (Prague grossi) were discovered in Budislavice even in 1917. Unfortunately, these coins were finally distributed in the systematic collection of the Museum of West Bohemia, and it is hard to get any information about them. But in 1964, another hoard from Budislavice was deposited in the Museum of West Bohemia. Typologically similar small coins – mostly of Bohemian origin – were of very bad condition. Torso of a vessel, in which the coins used to be buried, has been preserved. Later on, the content of this hoard was studied, and relevant basic data were published here, because of it is not impossible to find another hoard at the mentioned location.
Thaler of Hieronymus Schlick preserved in the collection of the Museum of East Bohemia in Hradec Králové
Authors: Brádle Vojtěch
Published: July 2019

The thaler of Hieronymus Schlick struck in 1527 is presented in this article. It comes from the hoard discovered in Nové Město nad Metují in 1923. Besides the coin in the Chaura collection, it is apparently the second known specimen of this sort with the name of Louis Jagiellon in its marginal legend. It is possible to say that both pieces were evidently made of the same pair of dies.