bluuebunny/crossref_metadata_2025 huggingface dataset:
ser del tiempo
Authors: Ramasco Ruth María
Published: December 2024

La concepción agustiniana del tiempo como distentio animi de Confessiones XI posee un complejo sustrato teórico, tanto en lo que respecta al horizonte problemático previo, como a las doctrinas que se hacen presentes en la resolución dada, sin que ello niegue o disminuya su originalidad. Por el contrario, es este mismo horizonte problemático el que permite resaltar el aporte del Santo de Hipona. De la complejidad de ese horizonte, nos interesa destacar dos elementos. El primero de ellos es la concepción estoica sobre las tres instancias temporales y la determinación del tiempo como incorpóreo. El segundo es la crítica del escepticismo académico sobre el ser del tiempo como totalidad, dada la inexistencia de cada una de las partes de ese todo; en el caso del tiempo, las aporías se plantean como aporías sobre el ser del pasado, el presente y el futuro. En ambos casos, el problema se presenta como un dilema sobre la relación entre temporalidad y ser. Consideramos que los argumentos agustinianos pueden ratificar su consistencia argumentativa al mostrarse como correlatos resolutivos de los problemas de este horizonte teórico. Además, la presencia de ejemplos y comparaciones que forman parte de este horizonte y de sus textos, permiten acentuar dicha consistencia.
Ό θεός: σπερματικός λόγος του κόσμου
Authors: Saeteros Pérez Tamara
Published: December 2024

El presente artículo pretende seguir el rastro de la noción de λόγοι σπερματικοί, clave de la explicación física estoica sobre la generación, y su inserción en la corriente neoplatónica, por la que consideramos que llega a Agustín de Hipona, quien la utiliza en su exégesis de los relatos de la creación que aparecen en las Escrituras. La racionalidad seminal es analógica, atraviesa y da sentido a la constitución misma del cosmos, y es ella misma, en su más elevada expresión, el Λόγος que era en el principio, fundamento de lo real.
Spatial and Temporal Trend Analysis of Rainfall Distribution in Nambiyar Watershed, Tamil Nadu
Authors:   Research Scholar, Department of Geography, Bharathidasan University, Tiruchirappalli, Tamil Nadu, Libina R S , Jegankumar R , Prakash K , Surya D Venkita , Dhanabalan S P , Arya M A
Published: December 2024

This study is an attempt to comprehend the spatial and temporal trend of rainfall distribution in the Nambiyar watershed. The daily rainfall data was processed for the period from 1988 to 2018 to map the spatial distribution and analyse the temporal trend of rainfall. The results reveals that mean annual rainfall received in the watershed is 1026.81 mm. Statistical techniques like Mann- Kendall test and Sen’s Slope estimator were used to analyse presence of trend and correlation of variables. Among four seasons northeast monsoon contributes around 47 per cent (482.57 mm) of the total rainfall. The results brought out the fact that annual rainfall of the watershed does not exhibit any significant trend at α=0.05 or 95% of confidence level. Agricultural and allied activities which requires adequate irrigation is determined by the rainfall received in this watershed. Hence this study brings out the spatial and temporal pattern of rainfall distribution in Nambiyar watershed.

Keywords: Rainfall trend, GIS, Sen's slope, Mann-Kendall test
The Impact of Precipitation Distribution on the Natural and Cultivated Vegetation Cover Changes in the Syrian Coastal Area for the Period 2000-2019
Authors:   Department of Geography, Bangalore University, Jnana Bharathi, Bengaluru, 560056, Karnataka, India, Karmoka Suzan , Hanjagi Ashok D
Published: December 2024

The study aims to determine the vegetation covers (natural and cultivated) affected by precipitation amounts in the Syrian coastal area from 2000 to 2019, and for this, precipitation data for 23 climatic stations were used, in addition to the spectral vegetation indices EVI and LAI from the MODIS satellite. The results showed that vegetation covers are affected by the amount of precipitation, but there is a difference in vulnerability degree in the cultivated and natural cover (forests). The cultivated vegetation covers were more affected by the decrease or increase in the precipitation amount, as the area is coastal and depends heavily on rainwater. The cultivated cover has declined significantly in the years with low precipitation, especially the years 2008, 2010, 2014 2016, while it responded well to the high precipitation values in 2003, 2012, 2015 and 2019. While the forests showed a slight impact on the decrease in the amount of precipitation due to their nature of adaptation to the conditions of the region, where most of the years maintained stable and high values for both EVI and LAI indices, except for 2014 and 2016 which were the years with the sharp decline in the amount of precipitation. When the forests were affected by the decline in precipitation in addition to the fires resulting from the crisis conditions in Syria, which increased the severity of damage in forest cover. This indicates that the forests were affected in the first place as a result of fires and in the second place as a result of precipitation, while the cultivated cover was mainly affected by the lack of precipitation.

Keywords

Coastal area, EVI, Forests, LAI, Precipitation, Vegetation cover
Delineation of Groundwater Potential Zones for Mavinahallikere Sub-Watershed of Kadur Taluk in Chikmagalur District, Karnataka State, Using Geospatial Technique
Authors:   Department of Applied Geology, Kuvempu University, Jnanasahyadri577 451, Karnataka, Shivamogga, India, Govindaraju Govindaraju , Somesha G S , Rakesh C J , Lokanath S , Kumar A Kishor
Published: December 2024

The present study shows the importance of remote sensing and geographical information system, which is found to be an effective tool for delineating groundwater potential zones of Mavinahallikere sub-watershed. Resource maps along with field investigation done to evaluate potential groundwater zones for the study area. The survey of India topographical map No. 57C/2 as the base and IRS LISS-IV satellite image (2015) used to prepare the thematic layers like drainage, lithology, geomorphology, lineaments, slope, land use/land cover and contours. The groundwater contour maps were prepared based on well details collected during fieldwork. Each unit of all thematic layers assigned with rank based on IMSD guideline and later integrated in the GIS platform to generate the groundwater potential map. The result shows that five distinct zones such as very poor, poor, moderate, good, and very good zones.

Keywords: Groundwater; Potential zones, Remote sensing, GIS
Spatio-temporal Assessment and Monitoring of Groundwater Quality for Irrigation in Cheyyar Watershed, Tamil Nadu
Authors:   Research Scholar, Department of Geography, Bharathidasan University, 620 024, Tiruchirappalli, 620 024, Tamil Nadu, India, Killivalavan J , Masilamani P
Published: December 2024

Groundwater is the major source of freshwater presence in the globe and supports human life on the earth and it is a critical resource for food security. In India since 1970s and now accounts for over 60 percent of the total area irrigated by groundwater in the country. Around 85% of the rural drinking water supply is also met from groundwater sources. Assessing the suitability of groundwater quality for irrigation is more important in increasing the yield of agricultural crops in an area. The Cheyyar watershed in Tamil Nadu has been selected as the study area to carry out the study since the study area has vast extension of agricultural land. The quality of groundwater in the study area has decreasing trend with respect to time. The total geographical area of the study area is around 2,060 sq.km. To carry out this study, data related to groundwater quality was collected from State Ground and Surface Water Resources Data Center, Tharamani, Chennai, Tamil Nadu for last 20 years (2000 – 2019) and nine parameters were selected to examine the irrigation suitability such as Magnesium Ratio, Sodium Adsorption Ratio, Residual Sodium Carbonate, Total Hardness, Soluble Sodium Percentage, Permeability Index, Total Dissolved Solids, Electrical Conductivity and USSL classifications. The weighted overly analysis has been used to derive the overall quality of groundwater for irrigation.

Keywords: Groundwater quality, Irrigation Suitability, Cheyyar watershed, USSL classifications
Assessment of Hypsometric Integral Status for Kumaradhara River of Dakshina Kannada, GIS Based Approach
Authors:   Department of Geography, Bangalore University, Jnanabharathi Campus, 560056, Bengaluru, Ravikiran T , Hanjagi Ashok D , Surendra P
Published: December 2024

The present study is aiming to find the Hypsometric characterises of Kumaradhara river basin area, which is located in central western ghat region at an altitude of 1480 average MSL. Hypsometric concept which helps in understanding the condition of river over period of time that river has been gone through stage of different life cycles of erosional activities. Hypsometric Integral (HI) is other important factor which helps in identifying the state of river condition that is going through with calculational factor elevation and rate of erosion that occurred in river basin or region that river flows. The study area region is located at mid of Central western ghat region which falls under the category tropical evergreen forest region and semi evergreen region. Very rich in flora and fauna. Home for nearly 70 types endemic plants types which are very crucial in condition. Providing shelter for nearly 12000 types of species from unicellular bacteria to angiosperms, 4000 types of flowering plants, and hub of various international and national acts such as (ECZ) Ecological Sensitive Zone, Biodiversity Heritage zone, Western Ghat Ecological Expert panel (EGEEP) and Hotspot zone for many Endangered species. For the study ALOS PALSAR data of DEM (Digital Elevation Model) is main source which is having resolution of 12.5meter data, is very high-resolution data of free of cost and Terrain Error corrected data. Student version ArcGIS Software 10.8 is used for analysis work Bhukosh and Survey of India (SOI) Toposheet data are utilized in this research work. In terms of Methodology to carryout activity DEM is classified according to elevation Range difference and classified into groups and area basin is calculated and according to Strahler method streams order of six classified and later Hypsometric Integral (HI) is calculated and finally by using that Hypsometric curve is plotted on map along with this various theme based maps were generated like Geology, Lithology, Stram order and Hill shade and Relief maps of study area is generated and maps were used in analysis work. The result of Hypsometric integral analysis revels that the Kumaradhara river is in between of Monodoc to Equilibrium stage where it gives hint of river is stage of erosion, still there is lot of stable bases for river erosion activity and different course erosional activity is still allowed and process is in stage of continuation of river erosional activities.

Keywords

Hypsometric, River Equilibrium, Hypsometric Integral, HI analysis
Identificação da atividade biológica de Streptomyces spp. contra Staphylococcus aureus resistentes
Authors: Lobo Ana Luiza Espínola , Campos Gabriel Gomes Nascimento , Carvalho Louisa Ferreira , Pinho Jaqueline Diniz , Freitas Aline Coelho Brandão de , Mesquita Ludmilla Santos Silva de , Santos Luciana Oliveira dos , Alves Matheus Silva
Published: December 2024

O filo dos actinomicetos, um dos principais filos do domínio das bactérias, é composto por bactérias Gram-positivas, aeróbias e filamentosas que apresentam uma grande diversidade metabólica, estrutural e reprodutiva. Essa variedade metabólica confere às bactérias alta adaptabilidade, tornando-as resistentes e capazes de colonizar e sobreviver em ambientes variados e de condições extremas. Esses microrganismos possuem uma vasta taxonomia, incluindo espécies com diferentes morfologias e capacidades metabólicas, dentre elas, o gênero Streptomyces se destaca pela habilidade em produzir metabólitos secundários bioativos com ação antimicrobiana contra bactérias resistentes, configurando grande importância biotecnológica e comercial. O presente trabalho objetivou apresentar a atividade biológica de Streptomyces spp. contra Staphylococcus aureus resistentes, pois são bactérias com alto teor de patogenicidade. Trata-se de uma revisão integrativa realizada por meio da base de dados “PubMed”, utilizando os descritores “Streptomyces” e “Staphylococcus aureus”. Foram incluídas meta-análises, análises e revisões sistemáticas publicadas entre os anos de 2014 e 2024 na língua inglesa. Por meio dessa busca, foram encontrados 17 artigos, dos quais 14 foram selecionados por abordarem o tema em questão. Esses estudos demonstraram a eficácia dos bioativos dos estreptomicetos no combate a patógenos multirresistentes, como os estafilococos estudados, sendo identificadas ações enzimáticas, antibiofilme e anti-MRSA. Logo, conclui-se a importância dos antibióticos derivados de Streptomyces spp. para a melhoria da saúde humana global.
Compliance e governança: mapeamento da produção científica internacional
Authors: Oliveira Elisabete de Farias Sousa , Fontgalland Isabel Lausanne
Published: December 2024

O objetivo deste estudo é analisar a produção científica internacional sobre compliance e governança, visando compreender as características das publicações científicas. Para isso, foi realizada uma análise bibliométrica usando métodos bibliométricos, incluindo técnicas de avaliação e relação, suportadas pelos softwares VOSviewer e CitNetExplorer. O protocolo de pesquisa consistiu em análise das publicações indexadas na base de dados da Web of Science, no período de 2014 a 2024. Foram executadas três etapas de filtragem, totalizando, ao final, 442 artigos. A etapa seguinte, constituiu-se de avaliação relacionada ao número de citações e publicações, periódicos, países e estudos mais relevantes do fator H (H-index). O uso dos softwares possibilitou a organização de cluster baseados em redes de coautoria e coocorrências de palavras-chave. Os resultados demonstram um aumento significativo na produção científica, especialmente entre 2020 e 2024, as instituições mais influentes nas pesquisas relacionadas a temática estão concentradas em países como os Estados Unidos (21,94%) e o periódico Elsevier é o mais relevante em termos de publicação. A rede de coocorrência de palavras-chave apresentou governança como tema central, seguido por compliance e gestão. As conclusões apresentam o panorama das publicações agrupadas com base em suas relações de citação em rede de citações com os estudos mais relevantes, demonstram os cluster com as publicações mais citadas e o ranking de publicações por score de citações, além disso, realizou-se uma análise nas obras consideradas referência na rede de citações, destacando os principais propósitose/ou resultados de cada estudo. Evidenciando, portanto, a relevância do tema, tendências, lacunas e como este vem sendo explorado.
A educação ambiental por meio da horta sustentável na Escola do Campo Km 70 em Canutama-AM, Brasil
Authors: Souza Valcemir Nunes de , Almeida Vanessa Santos de , Ferreira Kamyla Emanoella Caetano , Tupinambá Maria Jéssica , Oliveira Renilda Gomes de , Silva Viviane Vidal da , Lima Renato Abreu , Alecrim Alexandre Mascarenhas , Souza Júnior João Bosco Ferreira de
Published: December 2024

O projeto "A Educação Ambiental por meio da Horta Sustentável da Escola do Campo KM 70 em Canutama" destaca a importância de integrar a educação ambiental no ambiente escolar, promovendo práticas sustentáveis e a conscientização ecológica. Ao envolver alunos, professores e a comunidade em atividades de cultivo sustentável e agricultura orgânica, a iniciativa buscou não apenas elevar o conhecimento sobre questões ambientais, mas também fortalecer a colaboração e o engajamento social em prol da preservação do meio ambiente. Essa abordagem prática e interdisciplinar propicia uma formação mais consciente e comprometida com a sustentabilidade. A metodologia envolveu a seleção de uma área adequada para a horta, onde foram realizados preparativos como limpeza do solo e montagem de canteiros. Professores participaram de palestras sobre jardinagem sustentável e técnicas de agricultura orgânica, capacitando-os a orientar os alunos. A coleta de dados foi realizada por meio de análise do discurso, observações e entrevistas, permitindo uma compreensão profunda do impacto do projeto. Os resultados mostraram que a horta não apenas elevou a consciência ambiental dos alunos, mas também promoveu a integração da comunidade escolar em torno da preservação do meio ambiente. A discussão destacou a importância de práticas pedagógicas interdisciplinares, que enriqueceram o processo educativo e fomentaram uma cultura de colaboração. Nas considerações finais, enfatiza-se a necessidade de replicar a iniciativa em outras escolas e realizar estudos longitudinais para avaliar os efeitos a longo prazo. O projeto se mostrou um modelo inspirador para a construção de uma sociedade mais consciente e comprometida com a sustentabilidade ambiental.
Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria
Authors: Igbasi Uche T. , Oyibo Wellington A.
Published: December 2024

Background. Elevated endothelial activation markers are linked to malaria syndromes due to the sequestration of Plasmodium falciparum-infected red blood cells in deep tissue vessels. This study evaluated vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) levels in uncomplicated malaria and their association with host factors. Methods. A cross-sectional study was conducted in four health facilities in Ikorodu, Lagos State, Nigeria. Blood samples from children and adults were screened for malaria via microscopy, and plasma ICAM-1 and VCAM-1 levels were measured using ELISA. Results. ICAM-1 (1.03 × 106 ± 20,689.2 pg/ml) and VCAM-1 (1.11 × 106 pg/ml; range: 3,725–6,273,725 pg/ml) levels were significantly higher in malaria-positive cases compared to controls (p < 0.01). The geometric mean parasite density was 11,183 parasites/μl, but ICAM-1 and VCAM-1 levels did not correlate with parasite density (p > 0.1). Packed cell volume (PCV) was significantly lower in malaria-positive cases (p = 0.042), with ICAM-1 and VCAM-1 negatively correlating with PCV (p < 0.05). Both markers were also inversely associated with age (p < 0.05). Conclusion. VCAM-1 and ICAM-1 levels are elevated in uncomplicated malaria, independent of parasite density but negatively associated with PCV and age, highlighting the role of endothelial activation in malaria pathology.
The Effect of Price, Product Quality, Service Quality on Consumer Purchase Decisions at Solaria Cafe and Restaurant, Sorong City
Authors: Landjang Xenia Irene Sandy , Edwar Rizka Cintya , Mangopo Yuni Riskita , Damanik Lisa Gresti Sella
Published: December 2024

Business competition in this era of globalization seems increasingly tight along with the increasing business competition, consumers or buyers are increasingly careful in choosing products in terms of purchasing decisions. This study aims to analyze the effect of price, product quality and service quality on consumer purchasing decisions at the Solaria Café and Resto, Sorong City. The method used in this study is the quantitative method. The number of samples used was 190 consumers of the Solaria Café and Resto, Sorong City. Then the data collection technique by distributing and distributing questionnaires to predetermined samples. Furthermore, the data is processed using the SPSS analysis technique. The results of this study indicate that (1) Price has a positive and significant influence on consumer purchasing decisions (2) Product quality has a positive and significant influence on consumer purchasing decisions (3) Service quality has a positive influence on consumer purchasing decisions, this influence is not significant. So it is concluded that hypotheses 1 and 2 in this study are accepted while hypothesis 3 is not accepted.
Optimization and Verification of Sliding Saddle Structure in Machining Centers
Authors: Wen Zhuolin , Xu Yun , Li Qi , Ye Shuai , He Ling
Published: December 2024

As one of the key components of CNC machining centers, the structural performance of the saddle plays an important role in the machining accuracy of CNC machine tools. Taking the high-precision machining center of a certain factory as the research object, a finite element model of the sliding saddle is established. The ANSYS software is used to perform static analysis on the sliding saddle under extreme working conditions, analyze the deformation of the sliding saddle under this working condition, identify the weak links of the sliding saddle, and optimize its structure and size. Static stiffness verification and modal analysis verification are carried out. The results show that the optimized machining center saddle has high static stiffness and does not exhibit resonance under normal working conditions.
Innovación tecnológica para la sostenibilidad en América Latina
Authors: Juárez Merino Miguel Ángel
Published: December 2024

El objetivo de este artículo es analizar cómo la innovación tecnológica puede contribuir a la sostenibilidad en América Latina, para ello, se destacan los casos de éxito en ciudades de la región. Utilizando una metodología que combina el análisis documental y el estudio de casos, el artículo explora la correlación entre la digitalización urbana y el desarrollo sostenible. Los resultados indican que, aunque algunas ciudades han avanzado en la implementación de soluciones tecnológicas sostenibles, el progreso es desigual en la región y se presentan grandes desafíos relacionados con la desigualdad, la brecha digital y la falta de inversión adecuada.
Recent Strategies for Switching the Catalytic Selectivity in CO2 Hydrogenation
Authors: Zhang Lingling , Song Shuyan
Published: December 2024

Thermal catalysis is vital for converting carbon dioxide during hydrogenation into high-value-added chemicals. However, the intricate network of reaction pathways and intermediates leads to a diverse array of CO2 hydrogenation products, making achieving high selectivity difficult. Furthermore, in practical applications, changes to the catalyst induced by various factors can significantly alter its properties, resulting in a sudden shift in product selectivity, often referred to as selectivity reversal. Therefore, investigating the factors contributing to this selectivity reversal is essential for establishing a theoretical basis for regulating selectivity in CO2 hydrogenation. This paper reviews the factors influencing selectivity reversal, such as heteroatom modification, metal-support interactions (MSI), changes in the size of the active component, and intermetallic electronic interactions. Additionally, strategies to modulate the selectivity of CO2 hydrogenation are discussed. In conclusion, by exploring catalyst selectivity reversal and presenting methods to manipulate the selectivity of CO2 hydrogenation, this paper offers a guiding framework for the targeted design of catalysts and the precise modulation of CO2 hydrogenation products.
3D-Printing of Patterned Zn Anodes toward Dendrite-Free Zinc Ion Batteries
Authors: He Hanna , Zhang Chuhong
Published: December 2024

3D Zn anodes, boasting a high specific surface area to reduce the local current density, have emerged as promising electrodes for dendrite-free Zn-ion batteries (ZIBs). Despite their potential, the impact of diverse topological structures of Zn anodes on Zn deposition behavior within these electrodes remains poorly understood. To elucidate this relationship, this study employed direct ink writing technology to 3D print Zn anodes with four distinct topological configurations. The 3D array Zn anode featured with an angle between two connected printing strips of 180° (3DP-180) stood out for the fewest electrode joint points among these four anodes, migrating the tip effect and facilitating uniform electric field/ion distribution, which in turn promoted even Zn deposition and effectively suppressed Zn dendrites. The 3DP-180 array anode demonstrated a notably low nucleation overpotential of 27.2 mV, indicating a superior capacity for Zn nucleation and uniform Zn deposition. Moreover, symmetrical cell assembled with 3DP-180 array anode achieved 800 hours of continuous cycling without degradation at a current density of 1 mA cm-2 and a capacity of 0.5 mAh cm-2. These results highlight the improved cycle lifespan afforded by the superior structural design of Zn anodes, offering valuable insights to inform the development of next-generation durable and safe ZIBs.
An Analysis of the Impact of Metabolic Changes Caused by Obesity on Immune Response
Authors: Fang Junya
Published: December 2024

Currently, as obesity rates continue to rise globally, its complications are becoming increasingly detrimental to public health. Beyond its close association with chronic diseases such as cardiovascular disease and diabetes, obesity is also recognized as an important contributor to immune dysfunction. This study aims to investigate how obesity-induced metabolic changes interact with the immune response and increase the risk of infection and inflammation. Through a systematic literature review, this paper explores how obesity-induced metabolic changes affect the immune system through multiple pathways. The study specifically focuses on altered glucose and lipid metabolism, insulin resistance, and imbalances in adipokines and cytokines. It reveals how obesity-induced metabolic disturbances and chronic low-grade inflammation disrupt normal immune function, leading to increased susceptibility to infections, inflammation, and chronic diseases. It demonstrates a positive correlation between obesity and the risk of infection and inflammation, providing a comprehensive perspective on these interactions.
Research on schizophrenia based on dementia, working memory and episodic memory deficits
Authors: Zhang Qifan
Published: December 2024

Schizophrenia is associated with severe cognitive dysfunctions, including memory deficits that affect both working memory (WM) and episodic memory (EM). Memory deficits are also a typical symptom experienced by dementia patients that causes crucial functional problems in daily life. Meanwhile, past studies yielded evidence for the relationship between dementia and psychiatric disorders, indicating the emergence of psychotic symptoms during prodromal dementia. This article aims to investigate the relationship between schizophrenia and dementia plus the WM and EM deficits among schizophrenia patients. In the first part of this paper, the association between schizophrenia and dementia is examined based on a psychosocial study conducted among the Danish population, comparing the likelihood of developing dementia in patients with schizophrenia to that of individuals without schizophrenia. The review of previous research findings indicates a positive correlation between a diagnosis of schizophrenia and the later development of dementia. This phenomenon may be due to the reason that schizophrenia is positively associated with several established risk factors of dementia. Then, the topic of the potential deficits of WM and EM is discussed using self-ordered task results and neurobiological evidence. Studies have showed that schizophrenia is likely to lead significant WM and EM limitations that are closely related to prefrontal cortex impairment.
Clinical Efficacy and Safety Analysis of Alteplase in the Treatment of Acute Ischemic Stroke Patients
Authors: Sha Jiahui
Published: December 2024

In the treatment of acute ischemic stroke, alteplase plays a vital role as a thrombolytic drug, and as the social demand for it increases, its clinical application value has received increasing attention. In order to further explore the clinical efficacy and safety of alteplase in the treatment of acute ischemic stroke, the paper outlines the pathogenesis and clinical manifestations of acute ischemic stroke, and clarified the high prevalence and severity of the disease. Besides, the mechanism of action of alteplase and its clinical effect are analyzed, and it is found that it mainly dissolves thrombi, treats thrombotic diseases, reduces the risk of bleeding, and plays a significant role in emergency treatment. In addition, it compares the characteristics and advantages of alteplase with other thrombolytics, emphasizing the importance of various thrombolytic agents in medical practice through a review of relevant literature. Overall, the study aims to explore the clinical efficacy and safety of alteplase in patients with acute ischemic stroke. The results indicate that alteplase is effective in dissolving thrombi, treating thrombotic diseases and reducing the risk of bleeding. Despite certain side effects, its overall safety was still high. Therefore, alteplase shows safe and effective advantages in the treatment of acute ischemic stroke, with broad promotional value.
Small molecule compounds and monoclonal antibody therapy in lung cancer
Authors: Liu Silin
Published: December 2024

The leading cause of cancer-related mortality worldwide is lung cancer, with ongoing challenges in treatment efficacy and safety, but recent advances have been made in targeted therapies, including small molecule inhibitors and monoclonal antibodies, have significantly improved treatment precision and reduced side effects compared to traditional methods. Despite these developments, gaps remain in fully understanding resistance mechanisms and identifying novel therapeutic targets. This paper reviews the current state of targeted therapies for lung cancer, examining their mechanisms, clinical applications, and impact on patient outcomes. It provides valuable insights into how these therapies have advanced the field and highlights areas where further research is needed. Future studies should focus on addressing these gaps and exploring new approaches to optimize treatment and enhance patient survival rates.
Progress in the study of metastatic mechanism of colorectal cancer in vivo
Authors: Li Wanqing
Published: December 2024

The main object of this paper is colorectal cancer (CRC). Colorectal cancer is a malignant tumor that occurs in the colon or rectum. It is one of the most common cancers in the digestive system in the world. Its pathogenesis is complex and is related to many factors, including genetic factors and lifestyle habits. Mild cases can be treated and have a high probability of recovery, but severe tumors can even be fatal. For CRC, this paper includes its pathogenesis, metastasis mechanism, and corresponding intervention measures. Through research on these aspects, it aims to have a more comprehensive understanding of the causes, development process, and treatment strategies of CRC. The pathogenesis of CRC is usually affected by many different factors. This article will mainly discuss the factors of genetics, diet, and lifestyle. In terms of metastasis mechanism, tumor immune microenvironment, epithelial-mesenchymal transition (EMT), and vascular growth factors play a decisive and key role. Then this article also discusses intervention measures for CRC, including inhibiting the formation of new blood vessels, immunotherapy, and the use of chemotherapy agents.
An Analysis of the Connection between Type 2 Diabetes and Heart Failure
Authors: Zhang Jiaxin
Published: December 2024

Type 2 diabetes (T2D) and heart failure (HF) are two of the most prevalent chronic conditions worldwide, both of which contribute significantly to global morbidity and mortality rates. Individuals with T2D are at a 2-5 times higher risk of developing HF. At the same time, a substantial proportion of patients with HF also suffer from diabetes, introducing complex clinical challenges that complicate the management of both conditions. This article explores the links between T2D and HF, with a particular focus on shared pathophysiological mechanisms, risk factors, and clinical implications. Through a systematic literature review of peer-reviewed studies, this research identifies and critically evaluates the common pathways that contribute to the development and progression of both conditions, such as insulin resistance, chronic inflammation, and obesity-induced lipotoxicity. Additionally, the study discusses the impact of these mechanisms on the heart. It explores the potential for integrated therapeutic strategies aimed at simultaneously managing the metabolic and cardiovascular risks associated with T2D and HF. The findings underscore the importance of a holistic approach to patient care, emphasizing the need for early intervention and targeted treatments that address the dual burden of these interrelated conditions.
Advancements in Targeted Therapies Based on the EGFR, and KRAS Genetic Mutations in Lung Cancer
Authors: Feng Weiting
Published: December 2024

Non-small cell lung cancer (NSCLC), a type of lung cancer, has long been one of the leading causes of cancer-related deaths globally. Advances in understanding the genetic mutations associated with NSCLC, such as EGFR, and KRAS mutations, have led to significant progress in developing treatments tailored to them. However, despite these developments, challenges like drug resistance and variability in patient-specific responses still persist. This paper delves into the current research on genetic mutations in NSCLC, and the effectiveness of related treatments, focusing on the EGFR and KRAS gene mutations. While treatments have improved patient outcomes, they are often limited by various factors such as the development of resistance and off-target effects. This research highlights the importance of personalized treatments and emerging therapies, such as advanced drug delivery systems and new immunotherapies in overcoming these pre-existing limitations. The findings provide insight for future research and the need for continued innovation in treatments. The current unresolved issues such as patient-specific responses, secondary mutations, and the off-target effects suggest that developments in the near future might need to focus on enhancing personalization, the cost, and mechanisms regarding overcoming resistance.
Obesity Treatment from the Unique Perspective of Traditional Chinese Medicine
Authors: Zhang Shiqi
Published: December 2024

This paper aims to develop the value and significance of traditional Chinese medicine in the treatment of obesity in the context of the globalization of contemporary obesity, and to explore the causes and treatment methods of obesity. By examining the historical origins of traditional Chinese medicine principles, in conjunction with the teachings of the Emperor's Neijing, as well as the concepts of yin and yang, and qi and blood theory, this paper conducts an analysis on the traditional Chinese medicine perspective on obesity. Specifically, it explores the perception of imbalance in energy and organ function. This paper emphasizes the holistic nature of the human body and argues that treating obesity should not only focus on weight loss, but also on regulating internal organ function and balancing qi, blood, Yin, and Yang to improve overall health. At the same time, the effect of TCM dietary advice on weight loss was studied, and the role of herbal medicine and acupuncture in the treatment of obesity was explained, so as to provide new ideas and methods for the comprehensive treatment of obesity.
Advances and Implications of Histone Modifications in Prostate Cancer: A Brief Review
Authors: Xu Songlin , Li Changfu , Teng Lichen , Chen Yongsheng , Li Dechao , Kang Zhijian
Published: December 2024

Prostate cancer, a leading cause of cancer-related mortality among men, is increasingly linked to epigenetic changes, particularly histone modifications that affect gene expression and tumor behavior. This review explores recent advances in understanding how aberrant histone acetylation, methylation, and other modifications contribute to prostate cancer progression, metastasis, and therapeutic resistance. By analyzing these modifications' roles in regulating critical pathways, this paper aims to elucidate their diagnostic and therapeutic potential, suggesting that targeted epigenetic therapies may offer new avenues for treatment.
Sepsis Epidemiology and Outcomes in Pediatric Intensive Care Unit of Alkhadra Hospital, Tripoli, Libya
Authors: Fadelah Elghadban
Published: December 2024

Despite the various interventions and therapies that have been implemented to improve the quality of life for children with sepsis, the prevalence and death rates continue to increase. This issue is a major public health problem that requires the continuous improvement of the guidelines and the identification of new strategies. The aim of the study was to identify the prevalence and outcomes of severe sepsis among children admitted to the Pediatric Intensive Care Unit (PICU). This study was conducted in PICU of Alkhadra Hospital in 2023 as a hospital-based retrospective study. All children who were admitted to the PICU from 2017 to 2022 were included. Data was collected from hospital file records, which included the following: age of patient, gender, comorbidities of patients, and source of admission; origin of sepsis; type of PICU admission; primary site of infection; organ dysfunction present at screening; and patient outcomes. Of the 1284 total admissions to the PICU, 128 patients (9.96%) met the definition of sepsis. Most patients (78.9%) were less than 6 years old. Respiratory problems and congenital malformations were the most common co-morbidities, with reported rates of 18.8% and 10.2%, respectively. The emergency department was the most common source of admission (67.2%). Nearly all patients had good overall performance, whereas (21.1%) of the patients were in a coma. 77.3% discharged during the study, and 22.7% died. Although decreasing the incidence through preventive measures is ideal, early recognition and treatment of sepsis will decrease both short- and long-term complications and related mortality of at-risk infants and children.
Pengaruh Model Pembelajaran Cooperative Tipe Team Assisted Individualization terhadap Prestasi Belajar Peserta Didik
Authors: Rizzaludin Rizzaludin , Sumiyati Sumiyati
Published: December 2024

Penelitian ini adalah jenis penelitian eksperimen yang bertujuan untuk mengetahui pengaruh model pembelajaran kooperative team assisted individualization (TAI) terhadap peningkatan prestasi belajar peserta didik kelas VIII SMPN 5 Dompu pada mata pelajaran IPS tahun pelajaran 2023/2024. Populasi dalam penelitian ini adalah seluruh peserta didik kelas VIII SMPN 5 Dompu pada mata pelajaran IPS tahun pelajaran 2023/2024 yang berjumlah 28 orang. Karena jumlah populasi kurang dari 100 maka semua populasi dijadikan sampel penelitian. Dalam penelitian ini analisis data yang digunakan adalah analisis deskriptif. Langkah-langkah dalam meanganalisis data: 1. Pengumpulan data 2. Pengolahan data 3. Perhitungan statistic deskriptif 4. Analisis perbedaan 5. Uji korelasi. Dari hasil analisis data dan pembahasan dapat disimpulkan bahwa ada pengaruh model pembelajaran kooperative team assisted individualization (TAI) terhadap peningkatan prestasi belajar peserta didik kelas VIII SMPN 5 Dompu pada mata pelajaran IPS tahun pelajaran 2023/2024. Populasi dalam penelitian ini adalah seluruh peserta didik kelas VIII SMPN 5 Dompu pada mata pelajaran IPS tahun pelajaran 2023/2024. Hal ini ditunjukkan dengan nilai r hitung lebih besar dari rtabel (rhitung ≥ rtabel = 0,617 ≥ 0,374) dengan tingkat kategori pengaruhnya sangat kuat.
Model Pengembangan Mutu dan Relevansi Pendidikan Agama Islam dengan Konsep Kerjasama Pentahelix
Authors: Fitrianti Eka , Sirozi Muhammad
Published: December 2024

Penelitian ini bertujuan untuk menganalisis tantangan peningkatan mutu dan relevansi Pendidikan Agama Islam (PAI) dalam menghadapi perkembangan zaman dan kebutuhan penerapan ajaran Islam yang praktis. Tujuan utamanya adalah merumuskan model pengembangan PAI yang dapat menghadirkan perubahan signifikan, sehingga mampu membentuk generasi yang berkarakter dan berdaya saing tinggi. PAI memiliki peran penting dalam membentuk karakter dan moral generasi muda Indonesia, namun peningkatan mutu dan relevansi PAI semakin kompleks seiring dengan perubahan zaman. Penelitian ini menggunakan pendekatan Pentahelix—melibatkan pemerintah, akademisi, industri, komunitas, dan media—sebagai strategi inovatif untuk meningkatkan kualitas PAI. Metode penelitian yang digunakan adalah library research, yang mengkaji literatur terkait konsep Pentahelix dan aplikasinya dalam pengembangan PAI. Analisis meliputi landasan teori tentang mutu pendidikan, relevansi pendidikan, PAI, dan konsep Pentahelix. Penelitian ini juga menyajikan analisis kondisi mutu dan relevansi PAI serta potensi implementasi model Pentahelix. Kesimpulannya, kerjasama Pentahelix dianggap sebagai solusi inovatif yang dapat meningkatkan mutu dan relevansi PAI, serta diharapkan mampu menciptakan generasi muda yang berkarakter dan kompetitif di era modern.
Prinsip-Prinsip Perencanaan Pengembangan Sarana dan Prasarana Pendidikan Islam
Authors: Sormin Icha Aulia R. , Sirozi Muhammad
Published: December 2024

Perencanaan pengembangan sarana dan prasarana pendidikan Islam memegang peranan penting dalam menunjang proses pendidikan yang efektif dan efisien. Penelitian ini bertujuan untuk mengidentifikasi dan mengkaji prinsip-prinsip utama yang harus diperhatikan dalam perencanaan pengembangan sarana dan prasarana pendidikan Islam. Metodologi penelitian yang digunakan meliputi studi literatur, observasi lapangan, dan wawancara dengan para ahli pendidikan Islam serta praktisi perencana fasilitas pendidikan. Hasil penelitian menunjukkan bahwa prinsip-prinsip perencanaan yang efektif melibatkan integrasi nilai-nilai Islam dengan teknologi modern, pengelolaan sumber daya secara efisien, dan penciptaan lingkungan belajar yang kondusif. Tantangan utama yang dihadapi meliputi keterbatasan dana, kesenjangan infrastruktur antara daerah perkotaan dan pedesaan, serta resistensi terhadap perubahan teknologi. Namun, peluang yang ada, seperti peningkatan kesadaran akan pentingnya pendidikan Islam dan dukungan dari berbagai pihak, dapat dimanfaatkan untuk mengatasi tantangan tersebut. Penelitian ini memberikan rekomendasi praktis bagi perencana dan pembuat kebijakan dalam pengembangan sarana dan prasarana pendidikan Islam, termasuk pentingnya kolaborasi antara pemerintah, lembaga pendidikan, dan masyarakat. Selain itu, penelitian ini juga berkontribusi pada literatur tentang manajemen pendidikan Islam dengan memberikan wawasan tentang penerapan prinsip-prinsip perencanaan dalam berbagai konteks. Dengan demikian, diharapkan hasil penelitian ini dapat menjadi acuan dalam menciptakan lingkungan pendidikan yang lebih baik dan berkelanjutan, sesuai dengan nilai-nilai Islam.
Gerakan Literasi Sekolah melalui Pojok Baca pada Peserta Didik Kelas IV
Authors: Natalia Lisa , Nuranisa Nuranisa , Hermansyah Hermansyah
Published: December 2024

Gerakan Literasi Sekolah (GLS) merupakan gerakan sosial yang melibatkan berbagai elemen secara kolaboratif untuk meningkatkan minat dan keterampilan membaca siswa. Penelitian ini bertujuan untuk mengeksplorasi proses perencanaan, pelaksanaan, dan evaluasi Gerakan Literasi Sekolah melalui pojok baca di SDN 88 Palembang. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Pengumpulan data dilakukan melalui wawancara mendalam, observasi, dan dokumentasi. Subjek penelitian melibatkan guru, siswa, dan pihak sekolah yang terlibat dalam pelaksanaan pojok baca. Hasil penelitian menunjukkan bahwa perencanaan, pelaksanaan, dan evaluasi kegiatan GLS telah dilakukan oleh sekolah dan guru, namun masih terdapat berbagai kendala yang menghambat pelaksanaan optimal. Kendala utama terletak pada kurangnya koordinasi antara pihak sekolah dan guru serta minimnya persiapan yang dilakukan, yang menyebabkan implementasi pojok baca kurang efektif. Selain itu, evaluasi kegiatan juga belum maksimal karena belum ada mekanisme yang terstruktur untuk menilai dampak kegiatan terhadap peningkatan minat dan keterampilan membaca siswa. Penelitian ini menyarankan perlunya perbaikan dalam koordinasi, perencanaan, dan pelaksanaan untuk memastikan Gerakan Literasi Sekolah dapat berjalan secara efektif dan berkelanjutan.
Adaptasi Warna Bendera Namibia pada Busana Pesta Malam Model Draperi
Authors: Apriliani Fitria , Astuti Astuti
Published: December 2024

Tujuan dari penelitian ini adalah untuk menghasilkan karya berupa busana pesta malam dengan adaptasi warna bendera Namibia. Penelitian ini menggunakan metode pengembangan model ADDIE yang terdiri dari lima tahap: Analisis, Desain, Pengembangan, Implementasi, dan Evaluasi. Hasil penelitian ini berupa desain busana malam draped, di mana warna biru diadaptasi pada bagian lengan dengan teknik draped sleeve dan hiasan payet warna putih, warna hijau diaplikasikan pada bagian lengan dengan hiasan teknik beading, sedangkan warna merah diadaptasi pada bagian badan dengan garis leher berbentuk hati dan adaptasi motif matahari dari bendera Namibia. Warna kuning ditambahkan melalui teknik bordir beading dan payet warna putih pada bagian dada dan lengan.
Pengembangan Modul Cetak Interaktif P5 Berbasis Kearifan Lokal Sumbawa dalam Implementasi Kurikulum Merdeka
Authors: Suryani Erma , Nurhairunnisah Nurhairunnisah
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan modul cetak interaktif berbasis kearifan lokal Sumbawa dalam rangka mendukung implementasi Kurikulum Merdeka, khususnya pada proyek penguatan profil pelajar Pancasila (P5) sebagai bahan ajar alternatif bagi guru IPS di pelosok Batulante. Metode penelitian yang digunakan adalah Research and Development dengan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Penelitian ini hanya menggunakan tiga tahapan yaitu analisis kebutuhan terhadap bahan ajar di wilayah pelosok, desain dan pengembangan modul yang melibatkan para ahli pendidikan, serta praktisi di lapangan. Implementasi modul dilakukan di beberapa sekolah di Batulante dengan melibatkan guru-guru IPS sebagai subjek uji coba. Data dikumpulkan melalui observasi, wawancara, serta angket kepuasan guru dan siswa terhadap modul yang digunakan. Hasil penelitian menunjukkan bahwa modul cetak interaktif P5 ini layak digunakan guru dalam proses pembelajaran serta memperkuat pemahaman mereka terhadap konsep IPS yang dikaitkan dengan nilai-nilai kearifan lokal. Hasil validasi ahli Materi dengan skor 89,32% kategori sangat valid. Selanjutnya Hasil validasi ahli Media dengan skor rata-rata 84.68% kategori sangat valid. Ujicoba oleh guru diperoleh rata-rata 95% dengan kategori sangat baik dan respon siswa diperoleh rata-rata 78% dengan kategori baik. Hasil penelitian pada deskripsi guru-guru yang menggunakan modul ini merasa lebih terbantu dalam menyampaikan materi yang sesuai dengan Kurikulum Merdeka, khususnya dalam konteks daerah terpencil. Modul ini juga dianggap efektif dalam menjembatani keterbatasan infrastruktur teknologi di wilayah Batulante.