bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Feasibility of Additional Tumor Debulking to First-Line Palliative Combination Chemotherapy for Patients with Multiorgan Metastatic Colorectal Cancer
Authors: Gootjes Elske C. , van der Stok Eric P. , Buffart Tineke E. , Bakkerus Lotte , Labots Mariette , Zonderhuis Barbara M. , Tuynman Jurriaan B. , Meijerink Martijn R. , van de Ven Peter M. , Haasbeek Cornelis J.A. , ten Tije Albert J. , de Groot Jan-Willem B. , Hendriks Mathijs P. , van Meerten Esther , Nuyttens Joost J.M.E. , Grunhagen Dirk J. , Verhoef Cornelis , Verheul Henk M.W. ,   on behalf of the ORCHESTRA study group
Published: June 2020

Introduction

Local treatment of metastases is frequently performed in patients with multiorgan metastatic colorectal carcinoma (mCRC) analogous to selected patients with oligometastatic disease for whom this is standard of care. The ORCHESTRA trial (NCT01792934) was designed to prospectively evaluate overall survival benefit from tumor debulking in addition to chemotherapy in patients with multiorgan mCRC. Here, we report the preplanned safety and feasibility evaluation after inclusion of the first 100 patients.

Methods

Patients were eligible if at least 80% tumor debulking was deemed feasible by resection, radiotherapy and/or thermal ablative therapy. In case of clinical benefit after three or four cycles of respectively 5-fluorouracil/leucovorin or capecitabine and oxaliplatin ± bevacizumab patients were randomized to tumor debulking followed by chemotherapy in the intervention arm, or standard treatment with chemotherapy.

Results

Twelve patients dropped out prior to randomization for various reasons. Eighty-eight patients were randomized to the standard (n = 43) or intervention arm (n = 45). No patients withdrew after randomization. Debulking was performed in 82% (n = 37). Two patients had no lesions left to treat, five had progressive disease, and one patient died prior to local treatment. In 15 patients (40%) 21 serious adverse events related to debulking were reported. Postoperative mortality was 2.7% (n = 1). After debulking chemotherapy was resumed in 89% of patients.

Conclusion

Tumor debulking is feasible and does not prohibit administration of palliative chemotherapy in the majority of patients with multiorgan mCRC, despite the occurrence of serious adverse events related to local treatment.

Implications for Practice

This first prospective randomized trial on tumor debulking in addition to chemotherapy shows that local treatment of metastases is feasible in patients with multiorgan metastatic colorectal cancer and does not prohibit administration of palliative systemic therapy, despite the occurrence of serious adverse events related to local treatment. The trial continues accrual, and overall survival (OS) data and quality of life assessment are collected to determine whether the primary aim of >6 months OS benefit with preserved quality of life will be met. This will support evidence-based decision making in multidisciplinary colorectal cancer care and can be readily implemented in daily practice.
Hepatitis C Virus Infection and Chemotherapy in Breast Cancer: A Retrospective Chart Analysis
Authors: Ghosh Saptaparni , Chen Minghua L. , Weinberg Janice , Fikre Tsion , Ko Naomi Y.
Published: June 2020

Background

Breast cancer and hepatitis C virus (HCV) infection are major health problems in the U.S. Despite these highly prevalent diseases, there is limited information on the effect of HCV infection among patients with breast cancer receiving chemotherapy and the potential challenges they face during treatment. Currently, there are no guidelines for chemotherapy administration in HCV-positive patients with breast cancer.

Materials and Methods

We performed a retrospective case–control analysis on six patients with breast cancer with active HCV infection and 12 HCV-negative matched controls who received chemotherapy between January 2000 and April 2015. We investigated dose delays, dose changes, hospitalization, hematologic reasons for dose delays, and variation in blood counts during chemotherapy from the patients’ medical records. Fisher's exact test was used for statistical comparison of the outcome variables between the two groups.

Results

When compared with the HCV-negative patients, the HCV-positive group was at a significantly higher risk of dose delays (100% vs. 33%, p value .013), dose changes (67% vs. 8%, p value .022), hospitalization during chemotherapy (83% vs. 25%, p value .043), and hematotoxicity related dose delays (83% vs. 8%, p value .003). HCV-positive patients took a longer time to complete treatment than the HCV-negative group.

Conclusion

Patients with HCV receiving chemotherapy for breast cancer are more likely to experience complications such as dose delays, dose modifications, and hospitalization. Future studies to confirm our findings and investigate on the effect of concurrent HCV and breast cancer treatment are warranted.
Identification of instructional learning design by Alan Hoffer’s model and its effect on students’ creative thinking in mathematics
Authors: JEBUR Ayat
Published: May 2020

This study aims to know the effect of using instructional learning designs by Alan Hoffer’s model on students' creative thinking at the second stage of mathematic department in Axiomatic system and engineering. The experimental design created by a post-test divided into two groups in the academic year 2018-2019. The sample of experimental design is 86 male and female students divided into 43 students for the experimental group by the instructional learning design and 43 for the control group by traditional teaching methods. Two variables used in this study; an age, and the total average points of the experimental students of the previous stage (first stage). The researcher used 100 behavioral goals according to Bloom's classification in the field of knowledge of levels (knowledge, understanding, application, analysis, composition, evaluation), these behavioral goals based on the content of the scientific subject, and it has been presented it to a reviewer to determine the extent of their suitability in the preparation of study plans. A creative thinking test consisting of 21 items. The results of the study indicates that there are significant differences between teaching methods and instructional learning designs based on Alan Hoffer’s model on students’ creative thinking tests. This study concluded use Alan Hoffer’s model by teachers lead to developing a student’s creative thinking in mathematics and recommended for apply Allan Hoffer’s model in teaching, especially in engineering subjects in order to increase student’s creative thinking abilities, and provided the mathematic books of the students at schools with many activities in order to motivate students to complete learning and develop their mathematical thinking level.
Verhoeff’s Iron Hematoxylin Staining v1
Authors: Z. Chen Jeff , A. Howatt Deborah , K. Franklin Michael , J. Moorleghen Jessica , Sawada Hisashi , S. Lu Hong , Daugherty Alan
Published: May 2020

This protocol is used to stain elastic tissue. This results in elastic fibers and nuclei stained black. Staining of elasin allows for quantification of elastin breaks.
KEMAMPUAN VO2 MAX DAN KEMAMPUAN PEMULIHAN ATLET PENCAK SILAT
Authors: SUTISNA ROMI , Imanudin Iman
Published: June 2020

This study discusses the relationship of vo2 max capability and the ability of martial arts athletes recovery, the instrument used in this study by using balke test to measure vo2 max and using polar to calculate the pulse. The purpose of this study is to determine and explain whether there is a relationship between the ability of vo2 max and the ability of the athletes recovery pencak silat In this study the researchers chose purposive sampling as the appropriate technique for sampling which researchers took the selected people according to the specific characteristics possessed by the sample that as many as 10 men athletes based on research needs. Research instruments used are data analysis. This research is located in Bandung, West Java precisely at the stadium of Universitas Pendidikan Indonesia, The result states that VO2 Max from the lowest to the highest is 35.6-47.5 and the recovery pulse from the lowest to the highest is 115-159. The results of data processing showed the following discovery: "There is no significant relationship between VO2 Max and the recovery ability of the athlete of pencaksilat".  Kata kunci : Vo2 Max, pencak silat recovery
The Independence of a Simple Visual-Motor Reaction from the Preconscious Component of Sensation during Backward Masking by Two-Color Stimuli
Authors: Sobolev V.I.
Published: May 2020

The model of visual backward masking in its two-color modification is applicable in the study of the mechanisms of conjugation of the processes of sensory sensation formation and realization of sensorimotor reactions. The effect of the full (100 %) two-color backward masking is reliably implemented with the following values of its parameters: the duration of the test stimulus (red and green) is 0 ms, the stimulus masker (blue) is 45 ms, and the stimulus onset asynchrony (SOA) is 0.1 — 25 ms. In the range of SOA values from 25 to 35 ms, the efficiency of backward masking decreases to 14 %, and with an SOA of 40 ms, it completely disappears. The stimulus detection time (sDT) as part of a simple visual-motor reaction in the paradigm of the model of two-color backward masking does not depend on its effectiveness, the color of the test stimulus, the value of asynchrony in the range (0 — 40 ms), the duration of the stimulus-masker in the formation of a conscious light sensation. A comparative analysis of the stimulus detection time values under the conditions of full (100 %) backward masking and in its absence suggests that the mechanism of the two-color backward masking not associated with photoreceptors, but is implemented in the central parts of the visual analyzer.
«Tactile Pictogram» Method: Differences in Tactile Perception Strategies in Schizophrenia and Healthy Control
Authors: Maslennikova A.V. , Portnova G.V. , Nagibina N.L.
Published: May 2020

The article presents the results of a study of tactile perception. The phenomena of hypersensitivity and hypensensitivity in mental pathology are associated with chenges of reaction rate, thresholds of perception of tactile stimuli, or with physiological characteristics — a change in the tactile receptor system (McGlone F., 2014). This study was performed as an attempt to identify cognitive perception strategies (styles) for the tactile system, as well as their changes in patients with a hallucinatory-paranoid form of schizophrenia. The method, which we called the “tactile pictogram”, was developed to identify tactile perception features. Stimuli: eight textile samples (different fabrics), the same size and shape (A5), but different in structure, density, color and texture. Instruction: We allow the patient to touch the fabtic with closed eyes to feel it (fabrics presented one by one) and tell any words to memorize this fabric. After that, as a test it was necessary to find out the fabric according to your description. Subjects was 45 students (department of psychology), age 20 to 50 years. 24 patients with a hallucinatory-paranoid form of schizophrenia and schizotypic disorder (F20.0, F21.0 in ICD-10) aged 14 to 40 years. Patients at the time of the study were medicated, pathological symptoms persisted. All the received characteristics were combined into categories: “image”, “symbol”, “color and pattern”, “function”, “subjective evaluation”, “affiliation”, “objective evaluation”, “associations by place”, “character”. The answers of the subjects were coded according to the categories, expert assessments were used. The values of the U-test for the intergroup differences p = 0.05 for the categories “image”, “symbol”, “color and pattern”. In general, both healthy and schizophrenics used no more than three perception strategies. Some samples have recognizable features (cotton) and do not differ in characteristics in patients and healthy. Conclusions: 1. For tissue samples: cotton, fine viscose and thin felt for both groups, no differences between groups are revealed; 2. Intergroup differences in other samples showed a predominance of associative strategies in patients with schizophrenia (compared to healthy ones).
Speech Interaction in Triads «Mother—Dizygotic Twins» at the Age of the Children 4—6 Years
Authors: Kurazhova A.V. , Lyakso E.E.
Published: May 2020

The longitudinal study of mother speech interaction with 4-6-years-old dizygotic twins (n=5 triads) was performed. The characteristics of maternal speech addressed to twins, characteristics of children’ speech development due to the order of the birth are investigated. The first-born child in pair have a higher level of speech development as compared to the second-born child by syntactic structure of sentences in dialogue, number of consonants, meanings of pitch in vowels. Correlation between characteristics of maternal speech and the level of twin’s speech development is revealed. When mothers interact with the second-born twins they stimulate them to communication more then the first-born twins.
Reduction of Recognition of the Orienting Value of the Gaze as a Violation of the Mechanism of Joint Attention among Preschoolers
Authors: Smirnova Y.K. , Makashova A.V. , Kharitonova M.A.
Published: May 2020

The article discusses the role of the model of mental and separately the mechanism of joint attention in the normative age development of preschool children. It is shown that children with a lack of joint attention may experience difficulties in acquiring a wide range of developmental skills, and the ability to use the line of sight is part of a general mechanism that will further allow understanding and understanding the meaning of social information, the child’s ability to accumulate normal social experience. The hypothesis was verified that the developmental deficit of the mental model in children may be due to a decrease in the level of intellect: the difficulties of joint attention lead to an unformed component of the “objective-reflexive-normative thinking”. On a sample of 493 children of preschool age (typically developing and with mental retardation), a methodology was tested that assesses children’s understanding of the intentions and desires of others in the direction of gaze. It was found that the differences between typically developing children, children with lower bound and delayed age development can be tied to the fact that children who participate in joint attention can contribute to having more conditions to expand social learning opportunities. Changes in the accuracy of identifying the direction of sight shows the dynamics of the cognitive development of the child, which in comparison makes it possible to assess the characteristic differences not only in pathology, but at a decrease in the overall level of age development.
The Order of Information Transfer into Short- Term Memory from Visual Pathways with Different Spatial-Frequency Tunings
Authors: Alekseeva D.S. , Babenko V.V. , Yavna D.V.
Published: May 2020

Visual perceptual representations are formed from the results of processing the input image in parallel pathways with different spatial-frequency tunings. It is known that these representations are created gradually, starting from low spatial frequencies. However, the order of information transfer from the perceptual representation to short-term memory has not yet been determined. The purpose of our study is to determine the principle of entering information of different spatial frequencies in the short-term memory. We used the task of unfamiliar faces matching. Digitized photographs of faces were filtered by six filters with a frequency tuning step of 1 octave. These filters reproduced the spatial-frequency characteristics of the human visual pathways. In the experiment, the target face was shown first. Its duration was variable and limited by a mask. Then four test faces were presented. Their presentation was not limited in time. The observer had to determine the face that corresponds to the target one. The dependence of the accuracy of the solution of the task on the target face duration for different ranges of spatial frequencies was determined. When the target stimuli were unfiltered (broadband) faces, the filtered faces were the test ones, and vice versa. It was found that the short-term memory gets information about an unfamiliar face in a certain order, starting from the medium spatial frequencies, and this sequence does not depend on the processing method (holistic or featural).
The Role of Cognitive Factors in the Perception of Artificial Social Groups with Different Level of Social Typicality
Authors: Baleva M.V.
Published: May 2020

The study is devoted to the analysis of the role of cognitive styles and divergent thinking in the stereotyped and biased perception of outgroups identified by the criterion of social typicality. 191 participants (142 females and 49 males (26%) from 17 to 22 years old (M = 19.06, SD = 0.98) read 4 variants of stimulus texts containing information about artificial social groups with low and average levels of social typicality, and then filled in methodic forms aimed at measuring stereotyping, bias, cognitive styles and divergent thinking. It was found that under conditions of low social typicality, stereotyping was higher on the background of field-dependence, rigid control, impulsiveness, cognitive simplicity and weak originality. With the increasing of social typicality to an average level, the growth of stereotyping was determined just by the field-dependence and impulsiveness, and the effects of rigid control, cognitive simplicity and originality were weakened until complete disappearance.
Influence of the Stable Component of the External Appearance on the Perceived Age of a Person
Authors: Vorontsova T.A.
Published: May 2020

The “perceived age” of a person is the age attributed to him by another person in the process of perceiving his appearance. The research is devoted to the study of the influence of a stable component of a person’s appearance (the main body characteristics — height, weight and body mass index) on the perceived age of a person. The study involved 94 people: 30 women (18—49 years old) who attend weight loss courses; 24 women and 12 men (20—51 years old) who do not attend special weight loss courses; 28 evaluators (ordinary people from 22 to 45 years old) who evaluate the age of the study participants based on photos. The obtained data were analyzed using the Mann-Whitney u-test, Wilcoxon T-test, and Spearman correlation analysis. Conclusions: 1) women who have taken weight loss courses look younger than they did before losing weight; 2) men and women who do not attend weight loss courses look younger or older than their years depending on their weight and body mass index (those who look younger have a lower weight and index); 3) the results of weight loss in women differ depending on their attitude to their appearance, social needs, and parameters of psychological well-being. The conducted research proves the influence of the parameters of a person’s physique on his perceived age, confirms the determinative role of self-assessment of appearance in the implementation of various practices for the transformation of ones appearance.
Auto and Heterostereotypes of Tuvans and Komi: a Correspondence Analysis
Authors: Ananyeva K.I. , Basul I.A. , Demidov A.A. , Tovuu N.O.
Published: May 2020

The study of auto- and heterostereotypes of Tuvans and Komi was performed using a specially developed technique. The study conducted in the republics of Komi and Tuva, Russian Federation, involved 60 Komi and 130 Tuvans, respectively. Every participant was asked to perform a free classification of 36 psychological and behavioral traits, each represented by a separate card, relative to the proposed ethnic groups, in accordance with their ideas about these ethnic groups, as well as to characterize him/herself using the same characteristics. The data were processed using the correspondence analysis. The results signal the similarity of self-descriptions (self-image) and descriptions of their own ethnic group by the participants from Komi Republic, whereas significant differences were found in the self-descriptions and the descriptions of their own ethnic group by the Tuvans. We describe the “nuclear” characteristics of the Russian ethnos in the perception of the Tuvans and Komi. The results of the study of auto- and heterostereotypes of Komi and Tuvans can presumably be explained by the transformation of the ethno-cultural and socio-economic environment in the Republics of Komi and Tuva.
Gender Differences in the State of Volitional Regulation among Various Ethnic Groups of the Russian Federation and the CIS
Authors: Shlyapnikov V.N.
Published: May 2020

The hypothesis about the relationship between masculinity of national culture and the severity of gender differences in the state of volitional regulation among its representatives is tested. Men and women were compared among representatives of masculine (Kabardin, Ossetian, Armenians, Tatars, Bashkirs, Tajiks) and feminine (Russians, Ukrainians, Belarusians, Komi, Mari, Koreans, Tuvans, Jews) ethnic groups. In total, 1453 people aged 18 to 30 years participated in the study. To diagnose the state of volitional regulation of the respondents, the following methods were used: “Action-control scale” by Yu. Kuhl, “Questionnaire for revealing the expression of self-control in the emotional sphere, activity and behavior”, self-appraisals of volitional qualities. It is shown that in masculine cultures, men and women significantly differ in terms of the “Action-control scale”, the severity of emotional, behavioral and social self-control, as well as self-assessments of volitional qualities, while in feminine cultures there are practically no differences. Men demonstrate qualities associated with the implementation of intentions in action, and women demonstrate qualities associated with the organization of their activities in accordance with the requirements of society.
Assessing the Aircraft Crew Actions with the Aid of a Human Factor Risk Model
Authors: Kuravsky L.S. , Yuryev G.A. , Zlatomrezhev V.I. , Yuryeva N.E.
Published: May 2020

Presented is a human factor risk model when piloting an aircraft. This model is based on comparing representations of the evaluated crew actions with the comparable action representations of various types and performance quality, which form a representative sample and are contained in a pre-formed specialized database. The risk in question is represented by probabilistic estimates, which result from consistent applications of the Principal Component Analysis, Multidimensional Scaling, and Cluster Analysis to three types of characteristics, viz.: parameters of flights and states of aircraft systems, gaze movement trajectories and time series of oculomotor activity primary indexes. These steps form the clusters of flight fragments for various types and performance quality, including abnormal ones. The Discriminant Analysis provides calculating the probabilistic profile for belonging to certain target clusters, with a final conclusion being derived from this structure. Key elements of the approach presented are three new metrics used to compare crew actions and to ensure significant discrimination for flight fragments of various types and performance quality. Detailing flight parameters contributions in differences of the flight fragments in a given metric is carried out to provide meaningful analysis of the detected abnormality causes. With sufficient computational performance, the flight data analysis under consideration can be implemented in real time automatic mode.
The Approbation of Hopelessness Scale for Children (HLPS) on Non-Clinical Sample of Russian Students
Authors: Kagan E.S. , Belogai K.N. , Morozova I.S. , Borisenko Y.V. , Evseenkova E.V. , Gutova S.G. , Kindyakov A.A.
Published: May 2020

In this paper we analyze the suicide risk predictors among adolescents and consider interrelation between hopelessness and suicide risk to be especially important in this context. Also we provide the results of the empirical approbation of “Hopelessness Scale for Children” (HLPS) by А. Kazdin, A. Rodgers, D. Colbus on non-clinical sample of Russian students. 627 school and college students from Kuzbass region aged 13—18 years old participated in the study. Statistic analyses contained descriptive statistics analyses, correlation analyses, ANOVA, exploratory and confirmatory factor analysis, Student’s t-test. All analyses were performed with STATISTICA 10 and SPSS17. The statistics analyses helped to find among HLPS results two factors emerged using loadings greater than or equal to 0,30 to define the factors. The first factor includes items focused on negative self reflections and giving up. Second factor includes items phrased as positive reflections overall happiness as well as future expectations, which according to measure’s key in the lowest points may be interpreted as negative future expectations. Also the obtained factors and the summary hopelessness positively correlated with depression (Beck Depression Inventory, BDI) and mental stress (Nemchin’s Questionnaire), as well as personal and behavioral characteristics such as coping strategies, self esteem, and deviant tendencies among adolescents (Amirkchan’s Questionnaire). We have found the statistical differences in hopelessness between different samples of adolescents, such as school students, lyceum students and college students. Russian version of Hopelessness Scale for Children (HLPS) was proved to be valid and compact measurement for the adolescents screening. And its first factor — negative self reflections and giving up — has the greatest predictive value as predictor of depression and suicide risk among adolescents.
Antalya İlinde Üreticilerin Damla Sulama Desteği Almasını Etkileyen Faktörlerin Belirlenmesi
Authors: BEŞEN Tuba , SAYIN Betül , ÇELİKYURT Mehmet Ali , YILMAZ Şerife Gülden , KUZGUN Musa , BAHÇECİ Melike , AYDIN Başak
Published: May 2020

Bu çalışma, Antalya ilinde damla sulama desteği alan ve almayan işletmeler üzerinde yürütülmüştür. Her iki üretici grubunun tanımlayıcı özellikleri değerlendirilmiş ve damla sulama desteği alma durumuna etki eden faktörler incelenmiştir. Araştırma kapsamında 62 damla sulama desteği alan ve 62 damla sulama desteği almayan üretici ile yapılan yüz yüze anketler ile veriler toplanmıştır. Verilerin analizinde ortalama, yüzde oran, çapraz tablolar gibi tanımlayıcı istatistikler kullanılırken damla sulama desteği alınmasında etkili olan faktörlerin tespiti için İkili Lojistik Regresyon Analizi kullanılmıştır. Çalışma sonucunda üreticilerin tarımsal deneyimi, aile birey sayısı, hayvansal üretim gelirleri, bitkisel üretim gelirleri, toplam arazi büyüklüğü, sulanan arazi miktarları, tarım sigortası yaptırma durumlarının damla sulama desteği alan ve almayan grup açısından istatistiki olarak farklılık gösterdiği tespit edilmiştir. İkili lojistik regresyon analizi sonucunda, damla sulama desteği alma üzerinde üreticilerin aile birey sayısı, toplam işlenen arazi büyüklüğü, sulanan arazi büyüklüğü ve hayvansal üretim gelirlerinin etkili olduğu tespit edilmiştir.
Bertiz Kabarcık Üzümünde Bazı Kalite Özellikleri ile Toplam Fenol Bileşikleri ve Antioksidan Kapasitesinin Belirlenmesi
Authors: BALBABA Nazan , BAĞCI Sefair
Published: May 2020

Bu çalışmada, Kahramanmaraş bağcılığında önemli paya sahip Bertiz Kabarcık üzümüne ait bazı kalite ve fitokimyasal özellikler incelenmiştir. Yürütülen pomolojik analizler ile, üzüm örneklerinde salkım uzunluğu 15.87 cm - 23.94 cm, salkım genişliği 12.41 cm - 16.39 cm; tane ağırlığı 3.50 g - 4.80 g, tane uzunluğu 18.66 mm - 21.41 mm, tane genişliği ise 17.62 mm - 19.34 mm değerleri arasında kaydedilmiştir. Bertiz Kabarcık üzümünde SÇKM düzeyi (suda çözünebilir kuru madde) % 14.3 - % 23.0, titrasyon asitliği % 0.168 - % 0.365, pH 3.37 - 3.87 arasında değişmiştir. Maksutlu köyünden alınan 13. örnek ile, Budaklı köyünden alınan 7. örneklerde (sırasıyla % 93.5, % 93.0) antioksidan aktivite düzeyi diğer örneklere göre daha yüksek olarak elde edilmiştir. Çalışma sonucunda, toplam fenolik madde miktarının 44.3 mg GAE 100 g-1 ile 313.9 mg GAE 100 g-1 arasında değişen düzeyde olduğu belirlenmiştir.
Silisyumun Fasulyede (Phaseolus vulgaris L.) Tuz (NaCl) Stresini Azaltmadaki Etkisi
Authors: ORAL Erol , TUNÇTÜRK Rüveyde , TUNÇTÜRK Murat , KULAZ Haluk
Published: May 2020

Bu çalışma, farklı tuz (NaCl) dozu uygulamaları (kontrol, 50, 100 ve 150 mM) altında yetiştirilen fasulyede (Phaseolus vulgaris L.) silisyum uygulamalarının (kontrol, 50, 100 ve 200 ppm) bitkide bazı fizyolojik ve biyokimyasal parametreler üzerindeki etkilerini belirlemek amacıyla yapılmıştır. Fasulye bitkisinin kök ve gövde uzunluğu, kök ve gövde yaş ağırlığı, kök ve gövde kuru ağırlığı, yaprak alan indeksi, SPAD indeksi yaprak dokularında iyon sızıntısı, yaprak dokularında membran dayanıklılık indeksi ve malondialdehit (MDA) düzeyi gibi parametreler incelenmiştir. Çalışma sonucunda; tuz stresinin incelenen tüm parametreler üzerine olan etkisi istatistiksel olarak önemli bulunmuştur. Tuz stresi koşullarının yaprak dokularında iyon sızıntısı ve MDA dışındaki tüm parametrelerde azalışlara neden olduğu tespit edilmiştir. Silisyum uygulamalarının ise yaprak dokularında bağıl su içeriği, yaprak dokularında iyon sızıntısı ve yaprak dokularında membran dayanıklılık indeksi hariç diğer tüm parametreler üzerindeki etkisi istatistiksel olarak önemli bulunmuştur (p<0.05 ve p<0.01).
Ahlat ve Böcekte Kitosan ile Kaplamanın Etkisinin Belirlenmesi
Authors: GÜNEŞ Eda
Published: May 2020

Ahlat (Pyrus elaeagnifolia)’ın yüksek şeker oranına sahip olması, depo zararlıları ve böceklerin bu besine ilgisini arttırmaktadır. Kitosan gibi yenilebilir film ve kaplamalar, gıdaların bozulmasını önlemek ve raf ömrünü uzatmak için tercih edilmektedir. Bu amaçla Ahlat dilimleri kitosan ile kaplanmış (%0.2-2; KA) ve 30 gün boyunca Drosophila melanogaster erginlerinin bu armutlar ile beslenmeleri sağlanmıştır. Ergin bireyler ve Ahlat’larda tekstür analizi yapılmıştır. Artan oranlarda KA ile beslenme ergin bireylerin deri sertliğinin fazlalaşmasına neden olduğu belirlenmiştir. Sadece yenilebilir kaplama uygulanan Ahlat’larda kaplama oranının artmasıyla sertliğin azaldığı, üzerinde böcek beslenen Ahlat’larda ise sertliğin arttığı görülmektedir. %2’lik KA ile beslemenin böcekte sertlik oluşturup, yumurta oluşumunu engelleyen bir yöntem olarak belirlenmiştir.
Investigation of the Cytotoxic Effect of Ethyl Pyruvate on Various Cancer Cell Lines
Authors: AYAZOGLU DEMİR Elif , DEMİR Selim , TURAN İbrahim
Published: May 2020

Ethyl pyruvate (EP) is a simple aliphatic ester derived from pyruvic acid which is an endogenous metabolite. Although various studies have investigated the antioxidant and anti-inflammatory properties of EP, there has been only limited research into the cytotoxic effect of EP on cancer cells. The aim of this study was to determine the cytotoxic effects of EP on cells representing common cancer types. EP was purchased commercially and intermediate stock solutions were prepared with phosphate buffer saline. The cytotoxic effect of EP on human melanoma (VMM917), cervix (HeLa), breast (MCF-7), lung (A549), liver (HepG2), colon (WiDr) cancer and normal fibroblast (BJ) cells was determined using the MTT assay. Cisplatin was used as a positive control in cytotoxicity experiments. The results showed that EP exhibits selective cytotoxic effect on VMM917 (10.1-fold) and HeLa (3.04-fold) cells compared to BJ cells. This study shows for the first time that EP has a highly selective cytotoxic effect, especially on melanoma and cervix cancer cells. The mechanism of this effect needs to be elucidated by more extensive studies.
Petiole Anatomy of 21 Representatives of Tribe Alysseae (Brassicaceae) from Turkey
Authors: KARAİSMAİLOĞLU Cengiz
Published: May 2020

This paper presents in detail petiole anatomy of 21 representatives of tribe Alysseae, 5 of which are endemic from Turkey. In the examined taxa, differences have found in the petiole shape, arrangement and number of vascular bundles, and the presence of collenchyma. Petiole shapes are in sulcate, circular, or flat types. The most common type is sulcate with blunt or acute margins. The epidermises are in 1, 2 or more layer. The number of vascular bundles in the examined taxa varies between 1 (Berteroa mutabilis) and 9 (Alyssum strictum and A. strigosum subsp. strigosum) in total. In addition, vascular bundles in the middle are broadly or narrowly arc-shaped with 1-5 lobed. These results display that the compared petiole anatomical characteristics among the examined taxa are somewhat suitable to their delimitation in traditional rank in the Flora of Turkey.
Comparision of analgesic efficacy of ropivacaine and bupivacaine in rectus sheath block for midline abdominal surgeries
Authors: Kumar Raiger Lalit , Kuldeep Arti , Gehlot Ravindra , Sharma Mukesh , Gopal Jangir Krishan
Published: June 2020

In the modern setting the rectus sheath block (RSB) has been found effective in decreasing opioid requirement after both diagnostic and interventional laparoscopy and laparotomy. Efficacy of rectus sheath block (RSB) using ropivacaine versus bupivacaine for acute postoperative pain relief is not much investigated.

90 patients undergoing elective midline abdominal surgeries under general anaesthesia were randomly divided into three groups of 30 patients each, destined to receive bilateral rectus sheath block using 15 ml on each side (total 30 ml) of 0.25% ropivacaine in Group R, 0.25% bupivacaine in Group B or normal saline in Group C. Three groups were compared regarding time to first rescue analgesic from time of RSB (duration of analgesia), total rescue analgesic (tramadol) consumption in first 10 hours, visual analogue score (VAS), satisfaction score and adverse effects.

Mean duration of analgesia was significantly longer in group R (5.78±0.93h) than group B (3.63±0.90 h) and group C (2.37±0.44 h), p<0.001 (group R > group B > group C). This trend was observed in both hernia repair and laparotomy. Rescue analgesic consumption in terms of number of doses was significantly less in Group R (30) than in Group B (38) than in Group C (59), p<0.05. Mean VAS was significantly less and patient satisfaction was significantly better in Group R than in Group B than in Group C, (p<0.001)

Bilateral single shot rectus sheath block (RSB) using isobaric ropivacaine (0.25%) or bupivacaine (0.25%) is a safe and effective method of providing postoperative analgesia to patients undergoing midline abdominal surgeries. The lower cardio toxicity profile with the excellent prolonged postoperative analgesia makes ropivacaine an excellent choice for the RSB as compared to bupivacaine
Application of Raster to Vector Conversion in Power Electronics Thermal Infrared Images
Authors: Yordanov Krastin , Hadzhidimov Iliya , Popov Peycho
Published: May 2020

The infrared thermography today is widely used modern instrument for analysis of thermal fields in power electronics elements. On the other side, the heat fluxes causing temperature distribution of these elements and modules in working condition can be estimated in regimes of exploitation, while the cooling may be optimized in order to avoid damages of overheating. In present work, an algorithm and computer application for calculation temperature gradient on the surface of analyzed objects based on infrared thermal images is presented.
Changing of the Maintenance System in the Production Plant with the Application of Predictive Maintenance
Authors: Daneshjo Naqib , Malega Peter
Published: May 2020

The main goal of this paper is to analyse the current system of maintenance in selected company and after identification of crucial problems, to propose the new system of maintenance that will be built based on predictive maintenance. The paper is divided into three sections. First section treats predictive maintenance in theoretical plane. Second section deals with analysis of current situation in the selected company in the maintenance area, while in this section you can find information about spare parts consumption and failure rate per year. Third section is about the proposal of improving maintenance status by introducing predictive maintenance.
Analysis of Factors Influencing Communication and energy Consumption in Wireless Sensor Networks
Authors: Ganev Zlatan
Published: May 2020

The analysis and experiments presented in this paper are connected with propagation of signals between sensor nodes located in open area. The main purpose is to show some factors that affect the accuracy and reliability of the received signal strength (RSS) measurement as well as the determination of The Path Losses (PL), The Path Loss constant (n) and The Standard deviation (σ). The main factors considered here are: position and antenna orientation of sensor nodes and the distance between them.
Analysis of Neural Networks for Predicting Time Series When Assessing Industrial Safety Risks
Authors: Ya. Nagibin Sergey , I. Loskutov Dmitry
Published: May 2020

The paper describes the choice of an artificial neural network (ANN), the most effective for use in problems of modeling the behavior of complex dynamic systems with the subsequent solution of the forecast problem. The choice is made to implement a risk-based approach in the domestic trusted innovation umbrella system «Zodiac» when monitoring the industrial safety of the enterprises of the Fuel and Energy Complex (FEC).
Editorial Letter
Authors: Salehi-Abargouei Amin
Published: May 2020

This article is an Editorial and does not include an Abstract.
The Effect of Soy and Soy Products Consumption on Inflammatory Biomarkers: Protocol for a Systematic Review and Meta-analysis
Authors: Rezazadegan Mahsa , Mirjalili Fatemeh , Rouhani Mohammad Hossein
Published: May 2020

Background: Inflammation is a process that occurs in early phase of recovery in which immune system recognizes and removes immunological stimuli. Many chronic diseases have inflammation based pathogenesis. Several studies used soy and soy products for reducing inflammatory biomarkers.
Objectives: The purpose of the present systematic review and meta-analysis of randomized clinical trials is to determine the effects of soy and soy products on inflammatory biomarkers.
Methods: The following databases will be investigated for randomized controlled trials published until October 2019 to evaluate the effects of soybean and soy products on the inflammatory biomarkers in healthy subjects and patients with high inflammatory biomarkers: PubMed, Scopus, ISI Web of Science and Google scholar.Two independent investigators (M.R and F.M) will screen the title and the abstract of included articles. Mean and standard deviation (SD) or standard error (SE) for outcomes will be extracted. The quality of studies will be assessed by Cochrane Risk of Bias Tool. STATA software will be used to do a standard statistical analysis. A subgroup analysis will be applied to find out potential sources of inter-study heterogeneity. A Random-effects model will be conducted to calculate pooled effect size. A fixed-effect model will be incorporated to estimate the between-subgroup heterogeneity. Moreover, sensitivity analyses, Egger's regression asymmetry test and Begg's rank-correlation methods will be conducted.
Results: We will try to find a major number of articles about the effectiveness of soy and soy products on inflammatory biomarkers. Tumor necrosis factor α (TNF-α), interleukine 6 (IL-6), interleukine 2 (IL-2), interleukine 1-β (IL-1β), interferon-gamma (IFN-γ) and Interleukine 10 (IL-10) are considered to be the outcome.
Conclusion: The findings of this systematic review and meta-analysis may provide evidence on the effectiveness and safety of soy and soy products for reducing inflammation.
Barriers and Limitations to Obstacle Diabetes Self-Management with a Focus on Nutritional Literacy: Solutions and Opportunities. Critical Review and Research Synthesis
Authors: Mahmoodi Mohammad Reza , Khanjani Narges
Published: May 2020

Background: Researchers should seek applicable solutions and appropriate opportunities to solve or ravage barriers and limitations that worsen diabetes self-management and outcomes.
Objectives: The aim of this critical review and research synthesis was to explore whether the enhancement of nutritional literacy can optimize diabetes self-management and to identify barriers and limitations that obstacle diabetes self-management and to suggest the best available solutions and opportunities that were tailored to eliminate these barriers.
Methods: Data sources were PubMed and Medline databases. Studies were authorized if they were in English, used an observational or interventional design and were tailored based on the individual's nutritional knowledge or literacy in diabetes management among patients with diabetes. Databases were searched from February 1988 to December 2018. In order to evaluate the studies' quality, the abstracts that met PICO criteria for qualitative studies underwent dual review for data extraction. A qualitative synthesis was also conducted and the GRADE criteria were used to evaluate the quality of studies.
Results: A structured inventory consisted of six constructs (socioeconomic determinants, cultural determinants, education, access to health care services, family structure, and thoughts and personal practices) was designed based on the barriers and limitations. As a result, 151 solutions and opportunities were proposed. Most repeated solutions that were frequently suggested to eliminate the existing barriers, were: “The access to optimal nutrition and health literacy”, “Improved health care services”, “Health policies of governments”, “Sustainable lifestyle-based healthcare system”, “Proper implementation of nutritional intervention programs”, and “Comprehensive culturally sensitive diabetes education, and care programs”.
Conclusion: Identification and classification barriers and limitations to obstacle diabetes self-management are critical advances in accomplishing the interventions that can improve optimal diabetes outcomes, for different diabetic societies. Well-designed nutrition literacy intervention programs and preventive procedures may ameliorate the health status in diabetic population.
Fluid Intake and Functional Gastrointestinal Disease: A Narrative Review
Authors: Fallah Zahra , Ferns Gordon A , Ghayour-Mobarhan Majid
Published: May 2020

Background: Functional Gastrointestinal Diseases (FGIDs) impose a huge health burden, and lead to metabolic and mental disorders, impaired social function and productivity, reduced quality of life, higher total mortality and health care cost. Beverages are one of the major components of habitual dietary habits that may influence the symptoms of FGIDs.
Objective: The purpose of this study was to review the effect of frequent dietary fluids on common causes of FGIDS including functional dyspepsia (FD), irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD) and functional constipation (FC). Methods: A literature search was done using the following search engines: PubMed, Google Scholar and ISI web of science with the following search terms “beverages”, tea”, “caffeine”, “coffee”, “milk”, “water”, “fruit juice”, “carbonated beverage”, “constipation”, “irritable bowel syndrome”, “gastroesophageal reflux disease”, “dyspepsia”,.
Results: In this review, 85 studies were evaluated. It was shown that to higher intakes of caffeinated drinks, fruit juice, milk, soft drinks and carbonated beverages are associated with aggravating symptoms in GERD, IBS and FD. The data on the relation between water consumption with GERD, IBS and FD are limited and inconsistent. However, consumption of fruit juices and water was related to an improvement in constipation.
Conclusion: Fluid intake can be effective in the management of FGIDs symptoms. However, further investigation on the role of various fluids consumption on symptoms of FGIDS is required.
The Influence of Prayer on Critical Patients Admitted to the Intensive Care Unit
Authors: Amini Kiumarth , Sahebnasagh Adeleh , Mojtahedzadeh Mojtaba
Published: May 2020

Background: Critical patients admitted to the intensive care unit (ICU) might experience some degree of depression or anxiety, due to different treatments and medications they receive. These mental conditions can persist even years after hospital discharge. Therefore, the mental health of these patients is one of the particular interests. In this context, religious traditions and prayers are considered during the illness process. Objectives: The current article reviews the beneficial effects of prayer in light of research conducted in this area. Methods: A general search for electronic databases (Medline, Science Direct and Springer databases) was developed. The human studies of the influence of prayers in critically ill patients were evaluated. Results: The results indicated that prayer might be effective in reducing the severity of the disease in patients admitted to intensive care units and it has a positive effect on critical ICU patients. Conclusions: It is recommended that a prayer-based approach be taken to improve the mental health of these patients in a clinical setting.
TRENDS IN LEGAL REGULATION OF SOCIAL PROTECTION AS A PILLAR OF DECENT WORK AND A MOVING FORCE OF SUSTAINABLE DEVELOPMENT
Authors: Vyshnovetska Svitlana , Amelicheva Liliya , Olefir Viktor , Ierko Galyna , Petrenko Ganna
Published: May 2020

Purpose of the study: The purpose of the article is to identify trends in the legal regulation of social protection at the global, regional and national levels in the process of achieving decent work and sustainable development. The object of the study is the sphere of social protection as a pillar of decent work and a moving force of sustainable development, and its subject is the mechanisms of legal regulation of this sphere at the global, regional, and national levels.

Methodology: The methodological basis of the research is dialectics, synergies, and hermeneutics. The research methods cover a system of general scientific and special legal means and methods of knowledge, method of abstraction and generalization, analytical, formal-logical, and logical-semantic approaches.

Main Findings: It is proved that it is advisable to apply a synergistic approach to identifying and defining trends in the legal regulation of social protection as a pillar of decent work and a moving force of sustainable development. It is determined that in developed, developing countries and countries with economies in transition, there is a need to prepare modern National Social Protection Strategies at the legislative level or to improve existing strategies, taking into account the provisions of the 2030 Sustainable Development Programme and the ILO Decent Work Programme.

Applications of this study: The results of this research can be used to formulate public policy in social security and labor in Ukraine. Ideological findings will improve labor legislation. The research algorithm will be useful for students as well as graduate students in the study of labor law problems.

Novelty/Originality of this study: The originality of this research is the use of a synergistic approach for the consideration of social protection as the foundation of decent work and the moving force of sustainable development. This approach is unconventional in the science of labor law. It helped to identify important areas for improvement of legal regulation of social protection at the global, regional, and national levels.