bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic tools or clinical predictions: Which are better in palliative care?
Authors: Stone P. , Vickerstaff V. , Kalpakidou A. , Todd C. , Griffiths J. , Keeley V. , Spencer K. , Buckle P. , Finlay D. , Omar R. Z.
Published: April 2021

Purpose

The Palliative Prognostic (PaP) score; Palliative Prognostic Index (PPI); Feliu Prognostic Nomogram (FPN) and Palliative Performance Scale (PPS) have all been proposed as prognostic tools for palliative cancer care. However, clinical judgement remains the principal way by which palliative care professionals determine prognoses and it is important that the performance of prognostic tools is compared against clinical predictions of survival (CPS).

Methods

This was a multi-centre, cohort validation study of prognostic tools. Study participants were adults with advanced cancer receiving palliative care, with or without capacity to consent. Key prognostic data were collected at baseline, shortly after referral to palliative care services. CPS were obtained independently from a doctor and a nurse.

Results

Prognostic data were collected on 1833 participants. All prognostic tools showed acceptable discrimination and calibration, but none showed superiority to CPS. Both PaP and CPS were equally able to accurately categorise patients according to their risk of dying within 30 days. There was no difference in performance between CPS and FPN at stratifying patients according to their risk of dying at 15, 30 or 60 days. PPI was significantly (p<0.001) worse than CPS at predicting which patients would survive for 3 or 6 weeks. PPS and CPS were both able to discriminate palliative care patients into multiple iso-prognostic groups.

Conclusions

Although four commonly used prognostic algorithms for palliative care generally showed good discrimination and calibration, none of them demonstrated superiority to CPS. Prognostic tools which are less accurate than CPS are of no clinical use. However, prognostic tools which perform similarly to CPS may have other advantages to recommend them for use in clinical practice (e.g. being more objective, more reproducible, acting as a second opinion or as an educational tool). Future studies should therefore assess the impact of prognostic tools on clinical practice and decision-making.
Effect of spray-drying and ultraviolet C radiation as biosafety steps for CSFV and ASFV inactivation in porcine plasma
Authors: Blázquez Elena , Rodríguez Carmen , Ródenas Jesús , Rosell Rosa , Segalés Joaquim , Pujols Joan , Polo Javier
Published: April 2021

Spray-dried animal plasma (SDAP) is widely used in diets of domestic animals to improve health status and increase growth and feed efficiency. Individual steps in the SDAP manufacturing process, including spray-drying, have been validated to inactivate potential pathogens. Manufacturing standards have established a minimum exit temperature of 80°C and a minimum post-drying storage period of 14 days at 20°C for production of SDAP. Also, UV-C irradiation has been evaluated as another inactivation step that could be included in the manufacturing process. The aim of this study was to assess the inactivation effectiveness of spray-drying on Classical swine fever virus (CSFV) and African swine fever virus (ASFV) and the effect of UV-C inactivation on ASFV as redundant biosafety steps of the manufacturing process for producing spray-dried porcine plasma (SDPP). This study demonstrated that UV-C treatment of liquid porcine plasma can inactivate more than 4 Log10 TCID50/mL of ASFV at 3000 J/L. Spray-drying effectively inactivated at least 4 Log10 TCID50/mL of both CSFV and ASFV. Incorporating UV-C technology within the SDAP manufacturing process can add another biosafety step to further enhance product safety.
Target specific serologic analysis of COVID-19 convalescent plasma
Authors: Ikegami Sachie , Benirschke Robert C. , Fakhrai-Rad Hossein , Motamedi Mohammad H. , Hockett Rick , David Sean , Lee Hong Kee , Kang Jason , Gniadek Thomas J.
Published: April 2021

This study compared the performance of four serology assays for Coronavirus Disease 2019 (COVID-19) and investigated whether COVID-19 disease history correlates with assay performance. Samples were tested at Northshore using the Elecsys Anti-SARS-CoV-2 (Roche Diagnostics), Access SARS-CoV-2 IgG anti-RBD (Beckman Coulter), and LIAISON SARS-CoV-2 S1/S2 IgG (DiaSorin) as well as at Genalyte using Maverick Multi-Antigen Serology Panel. The study included one hundred clinical samples collected before December 2019 and ninety-seven samples collected from convalescent plasma donors originally diagnosed with COVID-19 by PCR. COVID-19 disease history was self-reported by the plasma donors. There was no difference in specificity between the assays tested. Clinical sensitivity of these four tests was 98% (Genalyte), 96% (Roche), 92% (DiaSorin), and 87% (Beckman). The only statistically significant differences in clinical sensitivity was between the Beckman assay and both Genalyte and Roche assays. Convalescent plasma donor characteristics and disease symptoms did not correlate with false negative results from the Beckman and DiaSorin assays. All four tests showed high specificity (100%) and varying sensitivities (89–98%). No correlations between disease history and serology results were observed. The Genalyte Multiplex assay showed as good or better sensitivity to three other previously validated assays with FDA Emergency Use Authorizations.
An analysis and systematic review of sarcopenia increasing osteopenia risk
Authors: Teng Zhaowei , Zhu Yun , Yu Xiaochao , Liu Jie , Long Qing , Zeng Yong , Lu Sheng
Published: April 2021

Sarcopenia is a progressive generalized skeletal muscle disorder, which may increase the risk of osteopenia. The aim of this study was to systematically review studies on the association between sarcopenia and osteopenia by pooled analysis. The PubMed and Embase databases were searched from inception to October 2020 for studies focusing on the association between sarcopenia and osteopenia. Two reviewers independently extracted data and assessed study quality. A pooled analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) using random-effects models. Subgroup analysis was conducted to explore the source of heterogeneity and the stability of outcome. A total of 25 independent studies involving 47,744 participants fulfilled the inclusion criteria. Sarcopenia significantly increased the risk of osteopenia (OR, 2.08; 95% CI, 1.66–2.60); Sensitivity analyses indicated the outcome was stable. Subgroup analyses showed that sarcopenia significantly increased osteopenia risk in each subgroup. No evidence of publication bias among the studies existed. In this study, our findings showed that sarcopenia significantly increased the risk of osteopenia. Thus, we suggest that sarcopenia can be a predictor of osteopenia risk.
Examining the relationships between income inequalities and different dimensions of well-being in selected Central Eastern European (CEE) countries
Authors: Szczepaniak Małgorzata , Geise Andrzej
Published: April 2021

This article examines the relationships between different dimensions of well-being and income inequalities across selected Central Eastern European countries after joining the European Union in 2004. Regarding the multivariety of well-being concept, it explores its 5 dimensions (material dimension, health dimension, education dimension, environmental dimension, happiness). Accounting for the interactions between dimensions of well-being matters for the inequalities, we conducted an in-depth analysis by adopting PMG estimation and panel ARDL model to assess the short-run and long-run links between variables. The results of conducted analysis allowed us to identify the canals through which income inequalities are linked directly or indirectly with the particular dimensions of well-being. In the long run, all the dimensions of well-being significantly affected income inequalities, and income inequality shaped material dimension, health, education, natural environment, and happiness. However, in the short run, the only dimension that shaped income inequalities was education. Income inequalities directly affected both health dimension and happiness.
Fear of pain moderates the relationship between self-reported fatigue and methionine allele of catechol-O-methyltransferase gene in patients with fibromyalgia
Authors: Ferrera David , Mercado Francisco , Peláez Irene , Martínez-Iñigo David , Fernandes-Magalhaes Roberto , Barjola Paloma , Écija Carmen , Díaz-Gil Gema , Gómez-Esquer Francisco
Published: April 2021

Previous research has shown a consistent association among genetic factors, psychological symptoms and pain associated with fibromyalgia. However, how these symptoms interact to moderate genetic factors in fibromyalgia has rarely been studied to date. The present research investigates whether psychological symptoms can moderate the effects of catechol-O-methyltransferase on pain and fatigue. A total of 108 women diagnosed with fibromyalgia and 77 healthy control participants took part in the study. Pain, fatigue, and psychological symptoms (anxiety, depression, pain catastrophizing, fear of pain and fear of movement) were measured by self-report questionnaires. Two types of statistical analyses were performed; the first was undertaken to explore the influences of COMT genotypes on clinical symptoms by comparing patients with fibromyalgia and healthy controls. In the second analysis, moderation analyses to explore the role of psychological symptoms as potential factors that moderate the relationship between pain/fatigue and COMT genotypes were performed. The main results indicated that patients carrying the Met/Met genotype reported significantly higher levels of fatigue than heterozygote carriers (i.e., Met/Val genotype) and higher levels of fatigue, but not significantly different, than Val homozygote carriers. Among patients with fibromyalgia carrying methionine alleles (i.e., Met/Met + Met/Val carriers), only those who scored high on medical fear of pain, experienced an intensified feeling of fatigue. Thus, the present research suggests that fear of pain, as a psychological symptom frequently described in fibromyalgia may act as a moderating factor in the relationship between the Met allele of the COMT gene and the increase or decrease in self-reported fatigue. Although further research with wider patient samples is needed to confirm the present findings, these results point out that the use of psychological interventions focused on affective symptomatology might be a useful tool to reduce the severity of fibromyalgia.
Modelling knowledge, health beliefs, and health-promoting behaviours related to cardiovascular disease prevention among Malaysian university students
Authors: Lim Bee Chiu , Kueh Yee Cheng , Arifin Wan Nor , Ng Kok Huan
Published: April 2021

Background

Healthy lifestyle habits formed during young adulthood may have a sustaining impact on health across later life. The current study aimed to test the theoretical model of factors (selected demographic variables, knowledge of heart disease, health belief related to cardiovascular disease (CVD), self-efficacy, cues to action, and screening intention) influencing health-promoting behaviours among Malaysian university students.

Methods

In a cross-sectional survey, the undergraduate students in Universiti Sains Malaysia were invited to complete the self-administered questionnaires. Participants were selected using a purposive sampling method. The proposed hypothesised model was analysed using a structural equation modelling with Mplus 7.3 program. A total of 788 (70.7% female) undergraduate students with a mean age of 20.2 (SD = 1.02) participated in the study. The primary outcome of knowledge, health beliefs, and health-promoting behaviours related to CVD were measured by questionnaires namely: Knowledge of Heart Disease, Health Beliefs Related to CVD, and Health Promoting Lifestyle Profiles-II.

Results

The final hypothetical structural model showed a good fit to the data based on several fit indices: with comparative fit index (CFI) at .921, standardised root mean square residual (SRMR) at .037, and root mean square error of approximation (RMSEA) at .044 (90% CI: .032, .054). The final structural model supported 13 significant path estimates. These variables explained 12% of the total variance in health-promoting behaviours. Through perceived benefits, total knowledge had an indirect effect on health-promoting behaviours.

Conclusion

The results suggest that perceived barriers, perceived benefits, family history of CVD, and screening intention enable young adults to engage in health-promoting behaviours.
Abundance and demography of common bottlenose dolphins (Tursiops truncatus truncatus) in the Indian River Lagoon, Florida: A robust design capture-recapture analysis
Authors: Durden Wendy Noke , Stolen Eric D. , Jablonski Teresa , Moreland Lydia , Howells Elisabeth , Sleeman Anne , Denny Matthew , Biedenbach George , Mazzoil Marilyn
Published: April 2021

Common bottlenose dolphins (Tursiops truncatus truncatus) inhabiting the Indian River Lagoon (IRL) estuarine system along the east coast of Florida are impacted by anthropogenic activities and have had multiple unexplained mortality events. Given this, managers need precise estimates of demographic and abundance parameters. Mark-recapture photo-identification boat-based surveys following a Robust Design were used to estimate abundance, adult survival, and temporary emigration for the IRL estuarine system stock of bottlenose dolphins. Models allowed for temporary emigration and included a parameter (time since first capture) to assess evidence for transient individuals. Surveys (n= 135) were conducted along predetermined contour and transect lines throughout the entire IRL (2016–2017). The best fitting model allowed survival to differ for residents and transients and to vary by primary period, detection to vary by secondary session, and did not include temporary emigration. Dolphin abundance was estimated from 981 (95% CI: 882–1,090) in winter to 1,078 (95% CI: 968–1,201) in summer with a mean of 1,032 (95% CI: 969–1,098). Model averaged seasonal survival rate for marked residents was 0.85–1.00. Capture probability was 0.20 to 0.42 during secondary sessions and the transient rate was estimated as 0.06 to 0.07. This study is the first Robust Design mark-recapture survey to estimate abundance for IRL dolphins and provides population estimates to improve future survey design, as well as an example of data simulation to validate and optimize sampling design. Transients likely included individuals with home ranges extending north of the IRL requiring further assessment of stock delineation. Results were similar to prior abundance estimates from line-transect aerial surveys suggesting population stability over the last decade. These results will enable managers to evaluate the impact of fisheries-related takes and provide baseline demographic parameters for the IRL dolphin population which contends with anthropogenic impacts and repeated mortality events.
‘La herida de un hombre no es una novedad’: Gender, violence and performance in Azul y no tan rosa
Authors: Brown Katie
Published: April 2021

Azul y no tan rosa was the first Venezuelan film to win the Goya for Best Spanish Language Foreign Film. It was also the first Venezuelan film to feature a kiss between two men, as well as an openly transgender character. At the heart of the film is a scene which cross-cuts between transsexual Delirio performing the 1980s Venezuelan pop hit ‘No soy una señora’ and a vicious homophobic attack. This scene exemplifies the film’s preoccupation with the performance of gender, its denunciation of machista violence, and its call for acceptance of difference.
«Potencia, no poder». De la fotografía como gesto de resistencia y migración
Authors: Cardona Elena
Published: April 2021

Hay imágenes poderosas y hay imágenes potentes. Todavía más, hay imágenes potentes que hacen resistencia al poder, que son acto y gesto de resistencia en sí mismas. Entre marzo y agosto del año 2017 la sociedad venezolana vivió uno de los períodos más sensibles de la ya prolongada crisis institucional del país, caracterizada visiblemente por cotidianas protestas de calle duramente reprimidas por las fuerzas de seguridad del Estado, fenómeno que fue nombrado por los medios de comunicación internacionales como la Primavera venezolana o la Rebelión de Abril. En un contexto hipermediatizado por las imágenes recirculadas por las redes sociales digitales y la prensa internacional, principalmente, destacan para mí los trabajos realizados por tres fotógrafos venezolanos: Gabriel Osorio, Vladimir Marcano Sifontes y Gabriel Méndez, cuyas fotografías testimonian experiencias traumáticas colectivas de resistencia al poder político en su propio «aquí y ahora» contingente, y articulan sus reflexiones desde el diálogo con ese otro sin nombre (el venezolano común, anónimo) en imágenes potentes que se tornan gestos de resistencia y migración.
Bolívar Echeverría y las asimultaneidades de la modernidad capitalista: Ethos barroco y blanquitud
Authors: Catalina Cristina
Published: April 2021

This article presents an approach to the way in which Bolívar Echeverría, based on his reformulation of Marxist criticism, attempts to locate in the truncated configurations of Latin American modernity potentials for resisting the universal expansion of the value form. Drawing on his distinction between modernity and capitalism, as well as his interpretation of the fundamental tension between natural form and value form, the article exposes Exheverría’s historical analysis of the triumph of the realist ethos over the baroque ethos of Latin American modernity. Nevertheless, the remnants of the latter constitute for Echeverría a possible counter-figure of the realistic ethos embodied by Whiteness. This is how his approach attempts to go beyond both Eurocentrism and the postmodern rejection of modernity, aiming to save the hope of a concrete universalism against the purely abstract universalism of capitalist modernity.
Clarice Lispector y la desistencia de ser
Authors: Villalobos-Ruminott Sergio
Published: April 2021

A partir de una de las últimas novelas de la escritora brasileña, Clarice Lispector, A hora da estrela (1977), y de la problematización de la relación entre literatura, representación y pobreza, este trabajo intenta dos cosas: (1) mostrar el complejo mecanismo utilizado por Lispector en la elaboración de su novela, como un trabajo de des-narrativización que interrumpe el proceso representacional desde una elaboración minimalista de la trama y del personaje; y (2) mostrar cómo, a partir de dicha presentación de la vida precaria de su protagonista, Macabea, también refe-rida como la nordestina, se hace posible una nueva relación entre literatura, crítica e historia.
Towards a ladder of popular music support in Wales: The educational impact of Forté Project
Authors: Thomas Luke
Published: April 2021

Introduced in 2016, Forté Project is a publicly funded talent development initiative aimed at young popular musicians residing in the Arts Connect region of South Wales. Using a combination of survey data and interviews with participants, this article analyses Forté Project’s educational impact on musicians, where it emerges as both complementary of, and a potential alternative to, music industry career pathways provided by traditional forms of further and higher popular music education. Within the wider context of the current Wales-based ladder of publicly funded popular music support, this article also investigates how Forté Project might be improved and/or expanded to better serve the educational needs of emerging popular musicians based throughout Wales.
Amy Wadge and her songwriting scholarship scheme at Lewis School Pengam
Authors: Jenkins Bethan
Published: April 2021

With a focus on songwriting, this article reports on the place of rock and pop as a means for generating creative output in the current Welsh secondary school curriculum. The article outlines how guidance from industry professionals in addition to a robust and relevant pop and rock curriculum can facilitate pupils accessing employment in the contemporary music industry.
The University of South Wales and Rockfield studios: A case study in industry collaboration
Authors: Gwilliam Andrew
Published: April 2021

This article is a descriptive look at the development of a strategic partnership between Rockfield studios in Monmouth and the University of South Wales. It considers how the relationship developed and tracks the holistic development of what was learnt from the experience of delivering a series of masterclasses between 2012 and the present day, which were developed to replicate industry practice in a way that is almost impossible in an academic setting.
Performance of Cartridge Based Nucleic Acid Amplification Test for the Diagnosis of Smear Negative Suspected Tuberculosis - A Study from a Teaching Hospital in Thrissur, Kerala, India
Authors: Sethumadhavan Anupama , Konikkara Kavitha Paul , Paul Davis
Published: April 2021

BACKGROUND In India, everyday more than 6000 people develop tuberculosis (TB) and more than 600 people die of TB (2 death every 5 minutes).1 World Health Organization (WHO) has recently endorsed cartridge based nucleic acid amplification test (CBNAAT) which has the potential to lead a revolution in the diagnosis of tuberculosis. This study intends to assess the performance of CBNAAT for the diagnosis of suspected smear negative pulmonary and extra pulmonary tuberculosis. METHODS The cross-sectional study was carried out in Department of Microbiology, Government Medical College, Thrissur, Kerala, India. CBNAAT was done in district tuberculosis center, Thrissur. The study was done from December 2016 to December 2017. Samples were sent for microscopy, culture and CBNAAT. RESULTS A total of 250 patients were evaluated. Majority of the specimens collected were sputum (61.2 %) followed by bronchial wash (17.6 %). Culture was positive in 48 specimens. CBNAAT was positive in 58 specimens. Both culture and CBNAAT were positive in 47 patients. CBNAAT was negative in 1 specimen but positive in culture test. CBNAAT detected an additional 10 samples. Taking culture as gold standard, culture positives were taken as true positives and culture negatives were taken as true negatives. Accordingly, true positive was 48, true negative was 202, false positive was 10 and false negative was 1. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were respectively 97.95 %, 95.2 %, 82.75 % and 99.5 %. CBNAAT missed out a sputum sample which was culture positive. CONCLUSIONS We found CBNAAT to be an important diagnostic modality especially in smear negative patients for early diagnosis and treatment of TB. Culture of mycobacteria is considered as a gold standard method, but it takes weeks to obtain a positive result and simultaneous detection of rifampicin resistance is not possible with this method. KEY WORDS Tuberculosis, Smear Negative TB, ZN Stain, AFB, Petroff’s Method, CBNAAT, RNTCP, Culture
Technology Enhanced Neuroanatomy Learning during Covid-19 Pandemic - A Questionnaire Based Study from a Teaching Hospital in Mysore, Karnataka, India
Authors: C.S. Vidya
Published: April 2021

BACKGROUND The present Covid-19 situation has created an era of learning through the electronic devices, where YouTube channel is playing an important role. Neuroanatomy is a complex subject requiring three-dimensional orientation of the structures. Practical teaching by using the cadaveric specimens is a usual practice, but in the current situation the virtual platform is an indispensable and sustainable option for both teaching and learning activities.In the present study the utility of YouTube and digital content on neuroanatomy was assessed among I MBBS students using selfadministered questionnaire during Covid -19 pandemic. METHODS The questionnaire based cross sectional study of prosected neuroanatomy specimens in the department of Anatomy were utilized to create digital content modules. According to the topics, PDF content was generated, and it was shared before the commencement of virtual class. Later YouTube link was shared with our I MBBS students through social media platforms like WhatsApp and Facebook regularly. At the end of completion of whole teaching schedule, a questionnaire was circulated to obtain the feedback on this teaching method. Finally, the responses were collected and interpreted. RESULTS In the present survey, 257 participants (176 females and 81 males) from 10 medical colleges responded to all 12 items of the questionnaire. We observed that 36 % of them graded excellent for content, 25 % for audio quality, 21 % for video quality, 29 % for specimens used, 25 % for labelling of specimens in YouTube videos. Out of 257 responses 35 % of them were graded excellent for pdf content, 30 % for pictorial representation of brain specimens, 30 % for labelling and 24 % for length. For overall rating for teaching learning method 35 % of them graded 8, 17 % graded 9 and 7 % of them have graded 10. CONCLUSIONS This mode of learning can be used for the purpose of distal education as per the convenience of the students, who are presently staying away from the campus. Our students have taken the benefit of teaching where the PDF and YouTube contents were appreciated by large number of students. KEY WORDS Neuroanatomy, YouTube, Digital Content, Technology, Learning Resources
Correlation of Computed Tomography Guided Visceral Adiposity & Sagittal Abdominal Diameter with Atherogenic Index of Plasma in Type 2 Diabetic Patients
Authors: Rao Pradyumna , Bindu Chavala Mohan , Ramachary Usha Setty Muthihar
Published: April 2021

BACKGROUND Type 2 diabetic patients are at high risk for many cardiovascular diseases which are associated with obesity and abdominal fat that includes visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Visceral adiposity contributes to impairment of insulin resistance which is a prerequisite for diabetes and dyslipidaemia. Computed tomography (CT) scan is the gold standard for measurement of VAT but due to its limitations, sagittal abdominal diameter (SAD) is considered which also has a strong correlation with VAT. There is a good relation between VAT and isolated lipid parameters. However, lipid ratios, such as Atherogenic Index of Plasma (AIP) are of higher predictive value for cardiovascular risk. The present study is focused on exploring the relationship between CT guided visceral adiposity and sagittal abdominal diameter with AIP in type 2 diabetic patients. METHODS This study was carried out with a study group of 53 type 2 diabetes patients aged between 25 to 65 years, incorporating appropriate inclusion and exclusion criteria in a tertiary care hospital. The biochemical assays done include triglycerides, HDLcholesterol and blood glucose by standard techniques. AIP was calculated by taking the logarithmic ratio of triglyceride and HDL-cholesterol levels. Measurement of visceral adiposity was done by SAD and CT scan. RESULTS A total of 53 patients with type II diabetes mellitus (DM) were recruited for the study comprising of 35 males and 18 females. Mean age of the patients was 41.717 ± 11.658 years. Mean value of SAD was 22.755 ± 2.70. Mean value of AIP was 0.164 + 0.15. Mean value of CT measured visceral adiposity was - 77.875 ± 24.54 HU. Pearson’s correlation coefficient for the relationship between SAD and AIP was 0.741 and Pvalue was less than 0.0001 indicating a positive correlation. Pearson’s correlation coefficient for the relationship between CT measured visceral adiposity and AIP was 0.765 and P-value was less than 0.0001 which also shows a positive correlation. CONCLUSIONS In our study we demonstrated that SAD and CT guided visceral adiposity was correlating with AIP in patients with type 2 diabetes mellitus. KEY WORDS Visceral Adiposity, Sagittal Abdominal Diameter, Atherogenic Index of Plasma, Diabetes Mellitus, Computed Tomography Scan
Endocrown - The Realm of Post-Free Endodontic Restorations
Authors: Anwarullah Anupreeta , Konagala Ravi Kumar , Raju Murali Krishna , Lingam Amara Swapna , U Lakshman Varma
Published: April 2021

With increased dental awareness, there has been a growing trend in patients who are opting for teeth retention, so post-endodontic restorations play a significant role in dictating restoration longevity. However, till date restoration of root canal treated teeth is still controversial. Root canal treated teeth often suffer from extensive loss of tooth structure because of access cavity preparation, caries removal, replacement of restoration and trauma.1 Traditionally the restorative material of choice for an endodontically treated molar would be post and core followed by metal / ceramic crowns. However, studies have shown that these intra-canal posts may increase risk, of undermining the residual tooth structure, root perforation and catastrophic failures.2 With adhesive strategies, there has been a paradigm shift towards post-less restorations and utilisation of pulp chamber as an extension, thus integrating the crown and core as a single unit or monobloc. 2,3 This was the concept of the endocrown technique. 3 Bindle and Mormann first, delineated the use of porcelain adhesive endodontic crowns.4 Endocrowns are more practical, conservative, aesthetic, simple to fabricate, economical, less time consuming and allows favourable distribution of masticatory stresses. Most studies on endocrowns showed comparable or somewhat superior results to other conventional treatments for endodontically treated teeth (ETT). However, the available literature is based largely on the use of ceramic endocrowns. 2-4 It was observed that data pertaining to endocrown fabrication with other indirect restorative materials is still limited, and the choice is still unclear.Indirect composites show enhanced mechanical properties, creation of ideal contacts and contours, favourable wear, aesthetics and can serve as an economical alternative to ceramics.5 Hence, this paper attempts to present a case report of functional and aesthetic rehabilitation of an endodontically treated molar with an endocrown restoration utilising indirect composite (SR Adoro System).
Psychological Disorders, Cognitive Impairment, and Quality of Life with Chemotherapy-induced Neuropathy in Colon and Rectal Carcinoma Patients
Authors: Hongyan Li , Wanting Lu , Fei Li
Published: April 2021

Purpose: To evaluate mental health, cognitive function, and living quality of colon and rectal carcinoma patients with oxaliplatin-induced neurotoxicity. Methods: Fifty recurrence-free colorectal cancer (CRC) patients with oxaliplatin chemotherapy while 50 control patients without oxaliplatin chemotherapy were enrolled in this study. Subjective and objective aspects of oxaliplatin chemotherapy symptoms were assessed with oxaliplatin neurotoxicity classification. Psychological assessment was measured via the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Cognitive function was measured via Montreal Cognitive Assessment (MoCA). Quality of Life (QOL) was assessed using the World Health Organization’s Quality of Life (WHOQOL-BREF) shortened instrument. Results: Of the patients with oxaliplatin chemotherapy, 41 patients had depression and 42 patients had anxiety. Patients with oxaliplatin chemotherapy scored higher on average on both the SDS (64.36 ± 7.22) and SAS (67.49 ± 9.41) compared to those without oxaliplatin chemotherapy (SDS, 57.86 ± 5.27, p=0.006; SAS, 61.57 ± 10.06, p = 0.004). Patients with oxaliplatin chemotherapy, on average, scored lower on the MoCA (23.46 ± 3.17) compared to patients without oxaliplatin chemotherapy (27.49 ± 2.03, p < 0.05). In addition, patients with oxaliplatin chemotherapy scored significantly lower on measures of physical health (18.9 ± 7.8 vs. 37.8 ± 6.2, p<0.05), psychological health (19.3 ± 8.2vs. 39.8 ± 8.1, p<0.05), and social relationship (50.2 ± 10.1 vs. 70.6 ± 10.5, p<0.05) compared to patients without oxaliplatin chemotherapy. Multivariate linear regression analysis demonstrated that anxiety and cognitive impairment performance significantly predicted for global Quality of Life (QOL). Conclusions: colorectal cancer (CRC)patients with oxaliplatin chemotherapy experience mood disorders, cognitive impairment, and reduced Quality of Life (QOL). The clinical symptoms severity of oxaliplatin cemotherapy plays an important role in mood change and cognitive function. Decreased Quality of Life (QOL) was associated with anxiety and cognitive impairment.
Morte e Classe Hospitalar: possibilidades para uma formação compreensiva do ser hospitalizado via hermenêutica-fenomenológica
Authors: Pinel Hiran , Ferreira Herberth Gomes , Bravin Rodrigo
Published: April 2021

O objetivo deste artigo é descrever de forma compreensiva a morte como possibilidade do Ser-no-mundo da Classe Hospitalar e as implicações para a formação de educadores que atuam nesse espaço. A metodologia utilizada foi a revisão de literatura e a nossa fundamentação teórica é a obra “Ser e Tempo” de Martin Heidegger (2012). Alguns conceitos próprios de Heidegger como “Dasein” e “Umwelt”, entre outros termos, como desenvolvida na chamada primeira fase de Heidegger em sua obra “Ser e Tempo”, perpassarão nosso trabalho. O Ser-no-mundo da Classe Hospitalar experimenta, com a internação, mudanças psíquicas e também na sua vida social que podem se transformar em angústia e medo da morte. Nesse sentido, um educador amoroso e compreensivo reconhece a morte como uma possibilidade existencial desse educando, mas atua no sentido de desenvolver práticas que colaboram para que ele amplie suas possibilidades de ser e consiga transcender o ambiente do hospital.
A história da educação no Hospital Pequeno Príncipe e a formação continua dos professores
Authors: Venâncio Ana Carolina , Peters Itamara , Costa Mariana Saad Weinhardt
Published: April 2021

O presente estudo descreve os aspectos históricos da educação de crianças e adolescentes hospitalizados, debatendo o modo como esse direito vem sendo organizado e os desafios de formação docente enfrentados para que o exercício legal se concretize e se efetive. Trata-se de uma pesquisa de caráter qualitativo descritivo, que elenca por amostragem as práticas desenvolvidas e o modo como o direito à educação da criança hospitalizada são garantidos por uma instituição filantrópica de Curitiba. A pesquisa descrita evidencia os aspectos da formação de docentes e educadores do Hospital Pequeno Príncipe tomando como base os estudos desenvolvidos durante a elaboração do projeto político pedagógico do Setor de Educação e Cultura do referido hospital e sua implementação.
The Impact of Tidal Flooding on Decreasing Land Values in the Areas of Tugu District, Semarang City
Authors: Utami Westi , Wibowo Yuli Ardianto , Permadi Fajar Buyung
Published: April 2021

Semarang City as one of the areas on the north coast has a serious problem related to tidal flooding. The impact of this disaster has implications for changes in land use, a decrease in environmental quality and health, the emergence of slum settlements, a decrease in income and also a decrease in land value. This study aims to map the impact of tidal flooding on changes in land values based on the Land Value Zone Map (ZNT) and map land prices based on spatial data analysis. The study was carried out through spatial analysis by overlaying (join intersection) the 2014, 2016, 2018 and 2019 ZNT maps to determine changes in land value, while mapping land prices, especially in Mangunharjo Village, was based on land use maps, positive accessibility (road network) and negative accessibility (prone flood rob). The results of the study show that land which is permanently affected by tidal flooding and cannot be used anymore makes it a lost / destroyed land, while periodically inundated land has experienced a price decline in the range of Rp 100.000 – 200.000, -/m2. Meanwhile, the results of the study from the ZNT map for 2014 to 2019 show a very significant difference in price between zone 1 and a price increase of ± Rp 3.500.000; zone 2 price increase ± Rp 575.000, -, zone 3 at a price range of Rp 385.000, and zone 4 as the tidal flood prone zone only experienced an increase of Rp 250.000,-. In this context, the variable of tidal flooding vulnerability greatly affects the stagnation of land prices and even decreases in land prices, while the positive accessibility variable is the location of land on national and local roads that has experienced a very high price increase.
The Effectiveness of Urban Forest in Absorbing CO2 Emission at Rajekwesi Type A Terminal
Authors: Anggara Oktavianus Cahya , Rahmawati Laily Agustina
Published: April 2021

The terminal in Bojonegoro District is Rajekwesi Type A Terminal. It is located close to the CBD that has resulted in a decrease in environmental quality, due to gas emissions released by motor vehicles. The decrease in environmental quality can be overcome with an ecological approach, for example by creating or expanding green open spaces (urban forest). This study aimed to provide information about the capability of urban forest of the terminal to absorb CO2 emissions. This study began with a survey counting the number of motor vehicles at the gateway of the terminal on Sunday, Monday, Wednesday, Friday and Saturday for 24 hours. Then, the measurement of tree biomass was carried out using the nondestructive method. After the data was collected, the amount of CO2 emissions from motor vehicles was calculated by adding up CO2 emissionsin a stationary (idle) position when it was moving. The total CO2 emissions of motor vehicles at Rajekwesi Type A Terminal was 292.058,087 kgCO2/year. The amount of carbon sink (Wtc) of a tree was calculated by multiplying the total biomass (Wt) by the carbon concentration. The amount of Wtc at the urban forest of Rajekwesi Type A Terminal was 4.366,059 kg/year. After the amount of Wtc was found out, the amount of CO2 absorbed by the tree could be found out by multiplying Wtc by the conversion constant of the carbon (C) element to CO2 (3,67). The amount of CO2 absorbed by the trees at the urban forest of Rajekwesi Type A Terminal was 16.023,44 kgCO2/year. If they were compared, the absorption of CO2 was still much smaller than the emission rate. Thus, the function of the urban forest of terminal as an absorber of CO2 emissions was still not optimal.
Pemantauan Kualitas Udara Kota Tegal (Studi Kasus : Kecamatan Tegal Selatan, Kecamatan Tegal Barat, Kecamatan Tegal Timur)
Authors: Pradifan Andika , Widayat Widayat , Suprihanto Agus
Published: April 2021

Pengelolaan kualitas udara dan pengendalian pencemaran udara harus dilakukan untuk menjaga kelestarian dan keberlangsungan kehidupan. Pengelolaan dan pengendalian pencemaran udara dapat dilaksanakan dengan melakukan pemantauan kualitas udara. Hasil dari pemantauan kualitas udara ambien selanjutnya digunakan untuk perhitungan IKU.  Indeks Kualitas Udara/IKU merupakan salah satu instrumen yang dapat digunakan untuk melakukan penilaian kualitas udara secara sederhana dengan menggunakan beberapa parameter terpilih.  Indeks Standar Pencemar Udara/ISPU, Parameter yang digunakan untuk menentukan ISPU yaitu Sulfur Dioksida (SO2), Nitrogen Dioksida (NO2),  Oksidan (O3), Total Partikel (TSP), Karbon Monoksida (CO), Amoniak (NH3), Hidrogen Sulfida (H2S), Weather Station (Suhu Udara, Tekanan Udara, Kelembaban Udara), Arah dan Kecepatan Angin, GPS (Koordinat Lokasi), Tingkat Kebisingan, dan PM10. Sedangkan untuk perhitungan Indeks Kualitas Udara menggunakan 2 parameter utama yaitu Nitrogen Oksida (NOx) dan Sulfur Oksida (SOx). Pengambilan sampel udara di Kota Tegal menggunakan alat High Volume Air Sampler (HVAS) dengan lama pengambilan selama 24 jam. Lokasi yang digunakan untuk pengambilan contoh kualitas udara ambien terletak di Jl. Dr. Cipto Mangunkusumo untuk pemantauan transportasi. Sedangkan untuk pemantauan kualitas udara dengan metode passive sampler memerlukan waktu selama 14 hari. Lokasi yang dipilih mewakili transportasi, kawasan permukiman, kawasan industri, kawasan perkantoran dan kawasan perdagangan. Pengambilan sampel kualitas udara ambien selama 24 jam digunakan untuk menghitung Nilai Indeks Standar Pencemar Udara (ISPU). Nilai ISPU pada lokasi pemantauan di Jl. Dr. Cipto Mangunkusumo (Terminal Kota Tegal) masing masing yaitu : SO2 sebesar 21,25, CO sebesar 10, NO2 sebesar 48, O3 sebesar 22,92 dan PM10 sebesar 40. Seluruh parameter termasuk dalam rentang 0 – 50 dengan kategori baik.
Community Development in Kemijen Village, East Semarang: A Corporate Social Responsibility in Practice
Authors: Purnaweni Hartuti , Yazid Irzaldi , Arifah Mutia Nur , Qomariah Anis
Published: April 2021

Companies, either state-owned and private which operates in the field and/or related to natural resources must implement Corporate Social Responsibility (CSR), such as by PT Indonesia Power (PT. IP) UBP-Tambaklorok which is located nearby Tanjung Mas Harbor, Tambaklorok Village, North Semarang District. Semarang City. The CSR implementation should benefit for both sides, the company for its image and the local community for the implemented programs. Therefore it is important to analyse perception of the local community as well as their opinions about the company's CSR activities in their village, in this case is the people of Kemijen village which is located adjacent to the PT. IP’s area. This research is descriptive qualitative, done in 2019, describing the phenomenon of CSR implementation by PT. IP, and the perception of the local community of Kemijen village towards the CSR activities implemented by PT. IP. The informants were taken using purposive sampling technique, covering both formal and informal leaders, the local people, as well as community development officer of PT. IP. Primary data was gathered using in-depth interview technique and observation. Secondary data consist of documents. Primary and secondary data was then coded and analysed interactively. PT. IP has formulated and implemented the Company’s strategies into CSR Roadmap 2015-2019, which is the grand strategy and a milestone of CSR implementation to integrate CSR strategy into the Company’s strategy, in the sectors of education, health, economy, and infrastructure. According to the perception of the Kemijen villagers, there have been both benefit and insufficiency of the PT. IP’s CSR implementation. They expect more programs to be implemented, in order to allowing them more opportunities for poverty alleviation.
Penggunaan Bahan Bakar Alternatif dalam Pengelolaan Tambang Batubara sebagai Sumber Energi yang Ramah terhadap Lingkungan
Authors: Tampubolon Frances Roi Seston , Yuwono Arief Sabdo , Tambunan Armansyah Halomoan , Achsani Noer Azam
Published: April 2021

Penggunaan alternative di masa masa seperti sekarang ini sangat diperlukan. Hal yang paling signfikan adalah penggunaan bahan bakar untuk pengolahan bahan mineral seperti batubara, nikel, tembaga dan lain sebagainya. Dengan penggunaan bahan bakar alternative akan memberikan solusi apabila dibandingkan dengan penggunaan bahan bakar fosil seperti minyak bumi yang sebentar lagi akan mulai habis. Batubara berkontribusi terhadap hujan asam dan kabut asap, terutama ketika dibakar tanpa scrubber. Studi LCA lengkap yang berisi analisis dampak (endpoint impact category) berdasarkan beberapa kategori kesehatan manusia (human health), ekosistem (ecosystem), dan sumber daya air (water resources). Analisis siklus hidup ini dilakukan untuk jenis logam di industri pertambangan. Analisis siklus hidup digunakan untuk menganalisis dampaknya terhadap kesehatan manusia dan pemanasan global. Akan dibutuhkan pengolahan dan penggunaan bahan bakar alternative tersebut sebagai sumber energi. Di dalam penelitian pengolahan data akan sangat dibutuhkan apabila pada saat melihat pengaruh dari penggunaan bahan bakar alternative terhadap kondisi lingkungan yang ada di sekitarnya. Dampak penggunaan listrik yang dikonsumsi untuk proses penambangan akan memberikan pengaruh terhadap meningkatnya efek pada pemanasan global. Fuzzy logic yang akan dikombinasikan dengan penggunaan metode LCA di dalam penelitian ini untuk membantu proses di dalam hal mengumpulkan data menggunakan kuesioner yang dipandu selama fase tujuan dan ruang lingkup (goal and scope) dan analisis persediaan. Selanjutnya metode open LCA untuk melihat hasil yang diperoleh dari data sekunder pada database yang diperoleh sebagai data sekunder. Dari hasil penelitian memberikan nilai 2,5 untuk proses land clearing dan top soil hauling dan nilai 2 untuk over burden stripping nilai 2 over burden disposal, nilai 2 untuk coal hauling dan hasil output memberikan nilai 0,529 untuk global warming potential.
Analisis Manifestasi Segragasi Politik Pelabelan dan Polarisasi di antara Kelompok Islam Sepanjang 2014-2019
Authors: Masykuri Romel , Ramadlan Mohammad Fajar Shodiq
Published: April 2021

Politik pelabelan merefleksikan dan mengekspresikan polarisasi dan kontestasi di antara kelompok Islam dalam politik. Label politik menjadi instrumen dan strategi untuk membangun citra dan persepsi dalam kontestasi dan konstelasi politik di Indonesia. Artikel ini menjelaskan bagaimana kontestasi di antara kelompok Islam termanifestasi melalui label untuk merebut klaim dan legitimasi politik. Metode process-tracing dan analisis konten digunakan untuk mengidentifikasi dan menjelaskan label di antara kelompok Islam. Selama 2014-2019, ada dua isu penting terkait politik pelabelan. Pertama, label berhubungan dengan konteks, hubungan kausalitas, dan tujuan atau konsekuensi dari pelabelan. Label merefleksikan pembingkaian tertentu dan pembeda antara kelompok. Kedua, segregasi dan polarisasi politik di antara kelompok-kelompok Islam selama 2014-2019 di Indonesia termanifestasi melalui konstruksi dan produksi berbagai label. Melalui label, sentimen agama dan perbedaan antar kelompok Islam menjadi instrumen untuk mobilisasi atau menggerus dukungan politik lawan dalam politik elektoral.
A mobile ecology of resources for Covid-19 learning
Authors: Narayan Vickel , Cochrane Thomas , Cowie Neil , Hinze Meredith , Birt James , Deneen Chris , Goldacre Paul , Ransom Lisa , Sinfield David , Worthington Tom
Published: April 2021

Mobile devices and a vast array of accompanying applications offer significant affordances to create, consume, share, collaborate and communicate—affordances that could be easily leveraged to facilitate meaningful learning. A positive disruption arising from COVID-19 that aligns with the affordances of mobile learning is the uncoupling of time and space in the learning process. Traditionally formal learning is a process that is predominately viewed as an experience that is ‘timetabled’— scheduled to eventuate at a ‘place’—lecture or a tutorial (or similar) in a room or lecture theatre. In this concise paper, an ecology of resources is discussed along with guiding principles for designing and facilitating uncoupled authentic and student-determined learning post the emergency remote teaching phase.
Peering into the crystal ball of the disengaged: What happens to students that do not submit an early assessment item?
Authors: Linden Kelly , Van Der Ploeg Neil , Hicks Ben , Gonzalez Prue
Published: April 2021

Established first year design principles highlight the need to provide early response systems for students who appear to be disengaging with targeted communication regarding available support services. One thousand, one hundred and s students were identified in session 1 that either: did not submit a pre-census early assessment item; or had limited learning management system activity. These students were then offered timely support, including on-the-spot advice and referral to other pre-existing support structures within the University. Students were identified from 77 subjects offered to commencing students, taught across 182 offerings. Of the students identified, 607 chose to defer or withdraw from their studies while 554 students remained. This raises the question, what became of those remaining students?