bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical LTP induces confinement of BDNF mRNA under dendritic spines and BDNF protein accumulation inside the spines
Authors: Bimbi Giorgia , Tongiorgi Enrico
Published: February 2024

The neurotrophin brain-derived neurotrophic factor (BDNF) plays a key role in neuronal development and synaptic plasticity. The discovery that BDNF mRNA can be transported in neuronal dendrites in an activity-dependent manner has suggested that its local translation may support synapse maturation and plasticity. However, a clear demonstration that BDNF mRNA is locally transported and translated at activated synapses in response to long-term potentiation (LTP) is still lacking. Here, we study the dynamics of BDNF mRNA dendritic trafficking following the induction of chemical LTP (cLTP). Dendritic transport of BDNF transcripts was analyzed using the MS2 system for mRNA visualization, and chimeric BDNF-GFP constructs were used to monitor protein synthesis in living neurons. We found that within 15 min from cLTP induction, most BDNF mRNA granules become stationary and transiently accumulate in the dendritic shaft at the base of the dendritic spines, while at 30 min they accumulate inside the spine, similar to the control CamkIIα mRNA which also increased inside the spines at 60 min post-cLTP. At 60 min but not at 15 min from cLTP induction, we observed an increase in BDNF protein levels within the spines. Taken together, these findings suggest that BDNF mRNA trafficking is arrested in the early phase of cLTP, providing a local source of mRNA for BDNF translation at the base of the spine followed by translocation of both the BDNF mRNA and protein within the spine head in the late phase of LTP.
Clinical vitamin A deficiency among preschool aged children in southwest Ethiopia
Authors: Nuredin Abdilwahid , Melis Tamirat , Abdu Abdu Oumer
Published: February 2024

Background

The clinical manifestations of vitamin A deficiency (VAD) involve night blindness, bitot’s spots, corneal xerosis, and corneal scars. It is the most important cause of preventable childhood blindness among children and causes morbidity and mortality. Even though Ethiopia implemented high-potency vitamin A supplements, the occurrence of VAD remains significant. This study was to identify determinants of clinical VAD among preschool-aged children (PSC) in southwest Ethiopia.

Method

A community-based survey was conducted among 411 randomly selected PSCs. A pretested and structured questionnaire coupled with clinical observation for signs of vitamin A deficiency by a trained ophthalmologist was used to collect the data. An anthropometric measurement of height was taken and analyzed using WHO Anthro to calculate Z-scores for each index. The public health significance of VAD was declared after comparison with international references. A bi-variable and multi-variable logistic analysis was done. We reported the adjusted odds ratio (AOR), 95% confidence interval, and p-value.

Result

A total of 411 children were screened for clinical VAD, and the overall prevalence was 2.2% (95% CI: 1.5–2.5). Of which, night blindness affects 1.2%, bitot’s spots affects 0.7%, and corneal xerosis affects 0.2%, indicating a major public health problem compared to the international reference. The odds of clinical VAD were 81% lower among children who received vitamin A supplementation (VAS; AOR = 0.19, 95% CI: 0.04–0.92). On the other hand, PSC of mothers who had attended ANC visits were 89% less likely to develop clinical VAD (AOR = 0.11, 95% CI: 0.02–0.53). In addition, the study revealed that the odds of developing clinical VAD are 82% lower among PSC aged 36 to 47 months (AOR = 0.18; 95% CI: 0.03–0.97).

Conclusion

The prevalence of clinical VAD among PSC is a public health problem and is associated with ANC visits, VAS status, and the age of the child, which could be used to target interventions to further reduce existing VAD. Further studies using reliable dietary intake and biomarker data could further depict the burden of subclinical VAD.
Tea intake and total body bone mineral density of all ages: a Mendelian randomization analysis
Authors: Xing Chen , Tan Yanrong , Ni Wentao
Published: February 2024

Background

There is increasing evidence indicating that tea intake affects bone mineral density levels; however, the causality between tea intake and bone mineral density is inconclusive. This study aimed to assess the causal relationship between tea intake and total body bone mineral density (TB-BMD) through two-sample Mendelian randomization (MR) analysis.

Methods

We conducted a two-sample MR approach to estimate the potential causal effects of tea intake on TB-BMD at all ages in a European population. The analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs), identified from a genome-wide association meta-analysis of tea intake (N = up to 447,485 individuals) and from the GEnetic Factors for OSteoporosis (GEFOS) Consortium’s genome-wide association meta-analysis (N = up to 56,284 individuals), with baseline data collected in 2018 and populations derived from the European ancestry. The association between each SNP and TB-BMD was weighted by its association with tea intake, and estimates were combined mainly using an inverse-variance weighted meta-analysis. In addition, we explored the potential causal effects between green tea intake, herbal tea intake, and TB-BMD.

Results

The MR analysis revealed that genetically determined tea intake exerts a causal impact on TB-BMD, with an odds ratio (OR) of 1.204 (95% CI: 1.062–1.366, p = 0.004), especially in the age group of 45–60 years (OR = 1.360, 95% CI: 1.088–1.700, p = 0.007). No horizontal pleiotropy and heterogeneity were observed. However, there was no causal effect of tea intake on TB-BMD in the age groups of 0–15, 15–30, 30–45, and over 60 years. In the subgroup analysis, when green tea intake was regarded as the exposure factor, no salient associations were found between green tea consumption and TB-BMD (IVW p = 0.368). Similarly, there was also no causal association between herbal tea intake and TB-BMD (IVW p = 0.264).

Conclusion

The findings of this study support the evidence that tea consumption increases bone density and reduces the risk of osteoporosis in the age group of 45–60 years within the European population.
Associations of trajectories in body roundness index with incident cardiovascular disease: a prospective cohort study in rural China
Authors: Zhang Shiru , Han Su , Zheng Liqiang , Sun Yingxian , Sun Zhaoqing
Published: February 2024

Aims

The body roundness index (BRI) has good predictive ability for both body fat and visceral adipose tissue. Longitudinal BRI trajectories can reveal the potential dynamic patterns of change over time. This prospective study assessed potential associations between BRI trajectories and incident cardiovascular disease (CVD) in rural regions of Northeast China.

Methods

In total, 13,209 participants (mean age: 49.0 ± 10.3 years, 6,856 [51.9%] male) were enrolled with three repeated times of BRI measurements at baseline (2004–2006), 2008, and 2010, and followed up until 2017 in this prospective study. Using latent mixture model, the BRI trajectories were determined based on the data from baseline, 2008 and 2010. Composite CVD events (myocardial infarction, stroke, and CVD death combined) was the primary endpoint. Cox proportional-hazards models were used to analyze the longitudinal associations between BRI trajectories and incident CVD.

Results

Three distinct BRI trajectories were identified: high-stable (n = 538), moderate-stable (n = 1,542), and low-stable (n = 11,129). In total, 1,382 CVD events were recorded during follow-up. After adjustment for confounders, the moderate-stable and high-stable BRI groups had a higher CVD risk than did the low-stable BRI group, and the HR (95%CI) were 1.346 (1.154, 1.571) and 1.751 (1.398, 2.194), respectively. Similar associations were observed between the trajectories of BRI and the risk of stroke and CVD death. The high-stable group was also significantly and independently associated with CVD, myocardial infarction, stroke, and CVD death in participants aged <50 years.

Conclusion

BRI trajectory was positively associated with incident CVD, providing a novel possibility for the primary prevention of CVD in rural regions of China.
Centering context when characterizing food environments: the potential of participatory mapping to inform food environment research
Authors: Downs Shauna , Manohar Swetha , Staromiejska Wiktoria , Keo Chanvuthy , Say Sophea , Chhinh Nyda , Fanzo Jessica , Sok Serey
Published: February 2024

Food environments are a critical place within the food system to implement interventions aimed at enabling sustainable diets. In this perspective article, we argue for the need for food environment research to more comprehensively examine the different types of food environments that people access within their communities to ensure that interventions and programs are better aligned with people’s lived experiences. We highlight the potential ways in which participatory mapping (PM) can be leveraged to better design food environment research by: (1) identifying the different food environment types that are accessed within a given community; (2) providing insight into the timing for data collection; (3) informing the prioritization of where to conduct food environment assessments; and (4) highlighting the dynamism of food environments over time (e.g., across a given day or across seasons). We provide a case study example of the application of PM and the lessons learned from it in Cambodia. By conceptualizing food environments in a more comprehensive way, from the perspective of the people living within a given community, we will be able to measure food environments in a way that more closely aligns with people’s lived experiences.
Study protocol for a zinc intervention in the elderly for prevention of pneumonia, a randomized, placebo-controlled, double-blind clinical pilot trial
Authors: Ortega Edwin F. , Wu Dayong , Guo Weimin , Meydani Simin Nikbin , Panda Alexander
Published: February 2024

Pneumonia is a major public health problem for older adults, being one of the leading causes of hospitalization and death, particularly for elderly nursing home residents. We previously conducted a clinical trial in which we demonstrated that 29% of nursing home residents had low serum zinc levels coinciding with a two-fold increase in pneumonia incidence and duration in comparison to individuals with adequate serum zinc levels. However, causality could not be inferred and necessitates a double-blind clinical trial. To determine the appropriate supplementation dose for such a trial we are conducting a randomized, placebo-controlled, double-blind clinical pilot trial aimed at delineating the optimal dosage (30 and 60 mg/day elemental Zn) and establishing safety. The results from the pilot study will be leveraged to inform our larger randomized clinical trial designed to study the effect of zinc supplementation in nursing home elderly with low serum zinc levels on respiratory infections, antibiotic use, and duration of sick days with pneumonia. In tandem with dose optimization, we will evaluate the correlation between serum zinc and pan-T cell zinc levels, given that T cells and their zinc levels are important in the response and resolution of respiratory infections but whose correlation has only been extrapolated and not demonstrated. Herein we present the study rationale and protocol, as well as discuss specific challenges we encountered in securing a manufacturer for the study agents and when recruiting from nursing home populations during the COVID-19 pandemic. In light of these experiences, we provide recommendations for future clinical trials under circumstances where supply chains are disrupted, and recruitment pools are constrained or unavailable.

Clinical trial registration

https://clinicaltrials.gov/, NCT05527899.
Body mass index and healthy lifestyle practices among Peruvian university students: a comparative study among academic discipline
Authors: Saintila Jacksaint , Calizaya-Milla Yaquelin E. , Carranza-Cubas Sandra P. , Serpa-Barrientos Antonio , Oblitas-Guerrero Susan M. , Ramos-Vera Cristian
Published: February 2024

Background

Excess body weight and an unhealthy lifestyle are a risk factor for noncommunicable diseases. University students are susceptible to unhealthy habits and obesity. This study compared body mass index (BMI) and healthy lifestyle practices among university students from four academic disciplines: Health Sciences, Business Sciences, Human Sciences and Education, and Engineering/Architecture.

Methods

A cross-sectional study was carried out using a sample of 6,642 university students selected by non-probability convenience sampling. The Diet and Healthy Lifestyle Scale (DEVS), the Peruvian validation of the Vegetarian Lifestyle Index (VLI), was used to assess healthy lifestyle practices.

Results

Students in the areas of Business Sciences and Engineering/Architecture had a higher BMI than their peers in Health Sciences (B = 0.35, 95% CI: 0.15–0.56 and 0.32, 95% CI: 0.13–0.52; p = 0.001). Additionally, these students tended to adopt less healthy lifestyle (B = −0.11, 95% CI: −0.20 to −0.01 and −0.09, 95% CI: −0.18 to −0.00; p < 0.05) compared to those in Health Sciences.

Conclusion

Although students of Health Sciences and Human Sciences and Education exhibited healthy lifestyle patterns, there is a clear need to improve eating and living habits in general among the university population to mitigate the risk factors associated with non-communicable diseases.
Cancer cell immunity-related protein co-expression networks are associated with early-stage solid-predominant lung adenocarcinoma
Authors: Nishimura Toshihide , Végvári Ákos , Nakamura Haruhiko , Fujii Kiyonaga , Sakai Hiroki , Naruki Saeko , Furuya Naoki , Saji Hisashi
Published: February 2024

Background

Solid-predominant lung adenocarcinoma (SPA), which is one of the high-risk subtypes with poor prognosis and unsatisfactory response to chemotherapy and targeted therapy in lung adenocarcinoma, remains molecular profile unclarified. Weighted correlation network analysis (WGCNA) was used for data mining, especially for studying biological networks based on pairwise correlations between variables. This study aimed to identify disease-related protein co-expression networks associated with early-stage SPA.

Methods

We assessed cancerous cells laser-microdissected from formalin-fixed paraffin-embedded (FFPE) tissues of a SPA group (n = 5), referencing a low-risk subtype, a lepidic predominant subtype group (LPA) (n = 4), and another high-risk subtype, micropapillary predominant subtype (MPA) group (n = 3) and performed mass spectrometry-based proteomic analysis. Disease-related co-expression networks associated with the SPA subtype were identified by WGCNA and their upstream regulators and causal networks were predicted by Ingenuity Pathway Analysis.

Results

Among the forty WGCNA network modules identified, two network modules were found to be associated significantly with the SPA subtype. Canonical enriched pathways were highly associated with cellular growth, proliferation, and immune response. Upregulated HLA class I molecules HLA-G and HLA-B implicated high mutation burden and T cell activation in the SPA subtype. Upstream analysis implicated the involvement of highly activated oncogenic regulators, MYC, MLXIPL, MYCN, the redox master regulator NFE2L2, and the highly inhibited LARP1, leading to oncogenic IRES-dependent translation, and also regulators of the adaptive immune response, including highly activated IFNG, TCRD, CD3-TCR, CD8A, CD8B, CD3, CD80/CD86, and highly inhibited LILRB2. Interestingly, the immune checkpoint molecule HLA-G, which is the counterpart of LILRB2, was highly expressed characteristically in the SPA subtype and might be associated with antitumor immunity.

Conclusion

Our findings provide a disease molecular profile based on protein co-expression networks identified for the high-risk solid predominant adenocarcinoma, which will help develop future therapeutic strategies.
Case Report: Tuberous sclerosis complex-associated hemihypertrophy successfully treated with mTOR inhibitor sirolimus
Authors: Shimoda Konomi , Iwasaki Hiroyuki , Mizuno Yoko , Seki Masafumi , Mimaki Masakazu , Kato Motohiro , Shinozaki-Ushiku Aya , Mori Harushi , Ogawa Seishi , Mizuguchi Masashi
Published: February 2024

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by a mutation in either of the two tumor suppressor genes, TSC1 and TSC2. Due to dysregulated activity of the mammalian target of rapamycin (mTOR) pathway, hamartomas or benign tumors frequently occur in many organs and are often treated with mTOR inhibitors. Hemihypertrophy is a rare complication of TSC. Although not being a tumor, progressive overgrowth of the affected limb may cause cosmetic and functional problems, for which the efficacy of mTOR inhibitors has not been reported previously. We herein report a case of TSC-associated hemihypertrophy. In this case, genetic studies revealed TSC1 loss of heterozygosity as the cause of hemihypertrophy. Clinically, pharmacological treatment with an mTOR inhibitor sirolimus successfully ameliorated cosmetic and functional problems with no intolerable adverse effects.
Islamic perspectives on preconception, prenatal, and perinatal counseling
Authors: Shoaib Abdullah Bin
Published: February 2024

With advances in prenatal imaging, genetic testing, and medical treatment of premature neonates, new bioethical challenges have arisen. Many Muslims turn to their faith and religious leaders to help navigate these novel challenges. This article briefly discusses the factors that are involved in religious leaders issuing a fatwa, or religious opinion. Using clinical scenarios, this article reviews the current discourse amongst Islamic scholars and laws in Muslim-majority countries regarding challenging bioethical topics surrounding preconception counseling, antenatal testing and termination of pregnancy, as well as Islamic scholars’ attempts to determine a minimum gestational age of viability using primary religious texts, the Quran and hadith. Challenges and shortcomings in the Islamic perspective on these issues are also addressed to highlight areas in which further research should be pursued. A deeper understanding of Islamic religious perspectives on these topics can help clinicians in providing care that is informed by patients’ cultural and religious values.
Neural network-based estimation of biomechanical vocal fold parameters
Authors: Donhauser Jonas , Tur Bogac , Döllinger Michael
Published: February 2024

Vocal fold (VF) vibrations are the primary source of human phonation. High-speed video (HSV) endoscopy enables the computation of descriptive VF parameters for assessment of physiological properties of laryngeal dynamics, i.e., the vibration of the VFs. However, underlying biomechanical factors responsible for physiological and disordered VF vibrations cannot be accessed. In contrast, physically based numerical VF models reveal insights into the organ’s oscillations, which remain inaccessible through endoscopy. To estimate biomechanical properties, previous research has fitted subglottal pressure-driven mass–spring–damper systems, as inverse problem to the HSV-recorded VF trajectories, by global optimization of the numerical model. A neural network trained on the numerical model may be used as a substitute for computationally expensive optimization, yielding a fast evaluating surrogate of the biomechanical inverse problem. This paper proposes a convolutional recurrent neural network (CRNN)-based architecture trained on regression of a physiological-based biomechanical six-mass model (6 MM). To compare with previous research, the underlying biomechanical factor “subglottal pressure” prediction was tested against 288 HSV ex vivo porcine recordings. The contributions of this work are two-fold: first, the presented CRNN with the 6 MM handles multiple trajectories along the VFs, which allows for investigations on local changes in VF characteristics. Second, the network was trained to reproduce further important biomechanical model parameters like VF mass and stiffness on synthetic data. Unlike in a previous work, the network in this study is therefore an entire surrogate of the inverse problem, which allowed for explicit computation of the fitted model using our approach. The presented approach achieves a best-case mean absolute error (MAE) of 133 Pa (13.9%) in subglottal pressure prediction with 76.6% correlation on experimental data and a re-estimated fundamental frequency MAE of 15.9 Hz (9.9%). In-detail training analysis revealed subglottal pressure as the most learnable parameter. With the physiological-based model design and advances in fast parameter prediction, this work is a next step in biomechanical VF model fitting and the estimation of laryngeal kinematics.
Effect of X-ray irradiation on the biological parameters of Xestia c-nigrum
Authors: Chu Shijiao , Liu Bing , Li Huan , Lu Keke , Lu Yanhui
Published: February 2024

The sterile insect technique (SIT) is widely used to control Lepidopteran pests by inducing inherited sterility. The noctuid moth Xestia c-nigrum is a polyphagous pest whose subterranean larvae severely injure cereals and some vegetables. The goals of this study were to assess the impact of X-ray irradiation on the development and survival of X. c-nigrum and use the data to select suitable sterilizing doses for potential future use in pest management. Batches of male pupae were exposed to 0 (control), 10, 30, 50, 100, 200, 300, or 400 Gy of X-rays, approximately 24 h before adult emergence. Exposure of late-stage pupae to 10–200 Gy of radiation had no significant effect on adult emergence, but all doses (10–400 Gy) reduced adult longevity, the number of spermatophores in mated females, and the number of eggs laid per female in the irradiated parental generation compared with the controls. Exposure to 10 and 30 Gy had no significant effects in the F1 generation on 1) the rate of egg hatch, 2) the duration of larval or pupal development, or 3) adult longevity. However, exposure to 50 Gy reduced the rate of egg hatch in the F1 generation, and when male pupae were exposed to 100 Gy only 1% of the F1 eggs hatched. Also at 100 Gy, the developmental durations of larvae and pupae were significantly prolonged, and longevity of adult moths was reduced. There were no significant differences between the control group and any treatments in 1) the sex ratio of the F1 adults, 2) the duration of F1 pre-oviposition or oviposition periods, or 3) the number of eggs laid per F1 female. Our findings indicate that a dose of 100 Gy can effectively slow pest development and reduce larval survival in the F1 generation. In addition, F1 adults from lines treated with 100 Gy were able to mate and lay eggs, but all F2 eggs failed to hatch. Our results suggest that use of X-ray irradiation has potential to control this polyphagous pest at the regional level.
Resisting wh-questions in business coaching
Authors: Dionne Frédérick , Fleischhacker Melanie , Muntigl Peter , Graf Eva-Maria
Published: February 2024

Introduction

This study investigates clients’ resisting practices when reacting to business coaches’ wh-questions. Neither the sequential organization of questions nor client resistance to questions have yet been (thoroughly) investigated for this helping professional format. Client resistance is understood as a sequentially structured, locally emerging practice that may be accomplished in more passive or active forms, that in some way withdraw from, oppose, withstand or circumvent various interactional constraints (e.g., topical, epistemic, deontic, affective) set up by the coach’s question.

Procedure and methods

Drawing on a corpus of systemic, solution-oriented business coaching processes and applying Conversation Analysis (CA), the following research questions are addressed: How do clients display resistance to answering coaches’ wh-questions? How might these resistive actions be positioned along a passive/active, implicit/explicit or withdrawing/opposing continuum? Are certain linguistic/interactional features commonly used to accomplish resistance?.

Results and discussion

The analysis of four dyadic coaching processes with a total of eleven sessions found various forms of client resistance on the active-passive continuum, though the more explicit, active, and agentive forms are at the center of our analysis. According to the existing resistance ‘action terminology’ (moving away vs. moving against), moving against or ‘opposing’ included ‘refusing to answer’, ‘complaining’ and ‘disagreeing with the question’s agenda and presuppositions’. However, alongside this, the analysis evinced clients’ refocusing practices to actively (and sometimes productively) transform or deviate the course of action; a category which we have termed moving around.
The relationship between nature exposure and depression among Chinese prisoners: a moderated mediation model
Authors: Zeng Yuze , Zhang Qingqi , Yan Jinglu , Qi Ke , Ma Ai , Liu Xiaoqian , Xiao Junze
Published: February 2024

Aim

This study examined the association between self-reported nature exposure and depression among Chinese prisoners, as well as the mediating and moderating effects of meaning in life and callous-unemotional (CU) traits, respectively.

Background

Prisoners are more likely to experience depression than any other mental illness. Exposure to nature has been proposed as a highly cost-effective method of treating their depressive symptoms. However, the mechanism underlying the link between nature exposure and depression among prisoners needs further investigation, as the findings may provide new insights into how to address depression in incarcerated populations.

Method

Data were collected through a survey conducted in four prisons in southern China from April to May 2022. The participants were 574 prisoners who anonymously completed four questionnaires about nature exposure, meaning in life, depression, and CU traits.

Results

The results show that: (1) meaning in life significantly mediates the association between nature exposure and depression, and (2) CU traits moderate the connection between nature exposure and meaning in life.

Conclusion

The current study uncovered that prisoners who contact more with the natural environment have a higher meaning in life and lower depression, and individuals with higher CU traits can benefit more from nature exposure.
The impact of core self-evaluations and person-job fit on work-related outcomes
Authors: Zhang Zongguo , Yan Zhen
Published: February 2024

Introduction

The aim of this study is to explore the mediating effect of emotional exhaustion (EE) between core self-evaluations (CSE), person-job fit (PJ fit) and service recovery performance (SRP). The current research also examines whether organizational dehumanization (OD) moderates the relationship between two antecedents, EE and SRP.

Methods

We collected time-lagged and multi-source data from star-rated hotels in three cities in China. In particular, direct supervisors of frontline employees (FLEs) rated their SRP (N = 32 supervisors and their 212 immediate employees). The hypotheses were gauged via PROCESS (version 3.4).

Results

The results indicate that CSE and PJ fit alleviate FLEs’ EE, which subsequently advances their SRP. OD moderates the direct impact of two antecedents on EE and SRP. Moreover, OD moderates the indirect influence of two antecedents on SRP through EE.

Discussion

The hospitality literature currently lacks an in-depth understanding of the underlying mechanism through which CSE and PJ fit affect FLEs’ SRP. This study incorporates EE as a mediator of the CSE’s and PJ fit’s impact on SRP, and to the authors’ knowledge, this is the first attempt to evaluate whether OD moderates the direct influence of CSE and PJ fit on SRP and the indirect impact of CSE and PJ fit on the aforementioned outcome via EE.
Trend of suicide by self-immolation in a 13-year timeline: was the COVID-19 pandemic a potentially important stressor?
Authors: Jeremic Jelena V. , Mihaljevic Jovan M. , Radosavljevic Ivan L. J. , Jurisic Milana M. , Suđecki Branko J. , Stojicic Milan T. , Jovanović Milan D. , Pavlovic Zorana , Radenovic Kristina G. , Milic Nikola V. , Pavlovic Vedrana , Milic Natasa M. , Jovic Marko S.
Published: February 2024

Introduction

Self-immolation is an uncommon way of attempting and committing a suicide, with a fatality rate of 80%. The risk factors in self-immolation victims vary depending on demographic characteristics, socio-economic and cultural factors as well as religious beliefs. Whether the COVID-19 pandemic was a potentially important stressor for self-immolation is still unknown, with insufficient studies examining this issue. Therefore, in this study, we aimed to examine the trend of self-immolation in a 13-year timeline, and the potential association of COVID-19 pandemic with the increase in the incidence and severity of self-immolation injuries in Serbia in 2021.

Materials and methods

The study included hospitalized patients due to intentional burns caused by self-immolation in the period from January 1, 2008 to December 31, 2021. Joinpoint regression analysis was used for the analysis of continuous linear trends of self-immolation cases with change points.

Results

While a rising trend was observed in the 2008–2013 time segment, followed by a decline in the upcoming 2013–2016 time segment, a significant increase reached its maximum during COVID-19 pandemic (2021), with annual percent change of 37.1% (p = 0.001). A significant increase in the median number of cases per year was observed during 2021 compared to the previous periods (7.5 vs. 2). Frequency of patients with a psychiatric diagnosis vs. those without a psychiatric diagnosis was significantly higher during than before the COVID-19 period (66.7 vs. 36.1%, p = 0.046).

Conclusion

In our study, a significant increase in the frequency of suicide attempts by self-immolation during COVID-19 pandemic was noticed. There was also an increased frequency of pre-existing psychiatric illness among patients during the pandemic period. With limited high-quality data available, the study adds to a rising body of evidence for assessment of outcomes of the pandemic on mental health and recognition of stressors for self-immolation.
Women’s views on content and delivery methods for interventions to improve preconception health: a qualitative exploration
Authors: Daly Michael P. , Kipping Ruth R. , White James , Sanders Julia
Published: February 2024

Background

Systematic review evidence suggests preconception health interventions may be effective in improving a range of outcomes. However, few studies have explored women’s views on potential content and delivery methods for these interventions.

Methods

Participants were purposively sampled from respondents (n = 313) of a survey. Semi-structured, in-depth interviews were conducted to explore their views on seven candidate delivery methods for preconception health interventions: general practitioners (GPs), nurse practitioners, pharmacists, social media, personal texts and emails, pregnancy tests, and health education in schools. Data were analyzed using a data-driven framework analysis.

Results

Twenty women were interviewed. Women wanted interventions to be easily accessible but allow them to conceal their pregnancy plans. They preferred to choose to receive preconception interventions but were receptive to health professionals raising preconception health during ‘relevant’ appointments such as contraceptive counseling and cervical smear tests. They wanted intervention content to provide trustworthy and positively framed information that highlights the benefits of good preconception health and avoids stigmatizing women for their weight and preconception actions. The inclusion of support for preconception mental health and the use of visual media, personalization, simple information, and interesting and unfamiliar facts were viewed favorably.

Conclusion

Interventions to improve preconception health should reflect the sensitivities of pregnancy intentions, be easy to access in a way that enables discretion, and be designed to seek consent to receive the intervention. These interventions should ideally be tailored to their target populations and provide trustworthy information from reputable sources. The potential for unintended harmful effects should be explored.
Validation of the Chinese version of the diabetes health profile to predict the impact of mobile health education on quality of life in type 2 diabetes patients
Authors: Lyu Xiaokang , Zeng Jinmei , Lin Jingna , Song Yixuan , Yang Tingting , Hou Wenjing
Published: February 2024

Purpose

The Diabetes Health Profile (DHP18), initially created in the United Kingdom, currently lacks a Chinese version. This study endeavors to authenticate the Chinese adaptation of the DHP18 and assess the influence of mobile health (mHealth) education intervention on the quality of life of individuals living with diabetes.

Patients and methods

The study included 470 Type 2 diabetes Mellitus (T2DM) patients (204 men, 266 women), spanning an age range of 19–79 years, with an average age of 54 ± 12.40 years. Data analysis employed Jamovie and Mplus software. Moreover, test–retest reliability was evaluated in 52 hospitalized T2DM patients through two repeated measurements taken 4 weeks apart.

Results

The Chinese version DHP18 scale exhibited high reliability, evidenced by a Cronbach’s alpha of 0.88, and coefficient of test–retest reliability of 0.84. Individual subscales also demonstrated strong reliability, ranging from 0.76 to 0.84, with test–retest reliability spanning from 0.71 to 0.74. Confirmatory Factor Analysis (CFA) employing a three-factor structure (χ2 = 294.69, GFI = 0.92, TLI = 0.91, RMSEA = 0.05, SRMR = 0.06) validated the scale’s construct validity. Notably, there was a statistically significant difference (p < 0.05) in the quality of life between Type 2 diabetes patients using mHealth education intervention and those without mHealth education intervention. Mediation analysis revealed that Appraisal of Diabetes (ADS) and Self-Management Efficacy (SED) mediated the effects of Psychological Distress (PD) and Behavior Adherence (BA) on quality of life, both significant direct and indirect effects (p < 0.001). In addition, Dietary Abstinence (DE) displayed significant overall impact (β = −0.13, p < 0.001) and indirect influence (β = −0.10, p < 0.01) on diabetic patients’ quality of life, though lacking a significant direct effect (β = −0.03, p = 0.38).

Conclusion

The Chinese version of the Diabetes Health Profile Scale meets stringent psychometric standards and stands as an appropriate measurement tool for Chinese T2DM patients, maintaining comparable results to the original scale’s structure. The mHealth education intervention yielded a notably positive impact on the quality of life among T2DM patients. Mediation analysis revealed that the three dimensions of the DHP were mediated by Appraisal of Diabetes and Diabetes Self-Management Efficacy, partially mediated by Psychological Distress and Behavior Adherence, and fully mediated by Dietary Abstinence, providing insight into the positive effects of the mHealth model on the quality of life of diabetic patients.
Revisiting the complex time-varying effect of non-pharmaceutical interventions on COVID-19 transmission in the United States
Authors: Wu Gonghua , Zhang Wanfang , Wu Wenjing , Wang Pengyu , Huang Zitong , Wu Yueqian , Li Junxi , Zhang Wangjian , Du Zhicheng , Hao Yuantao
Published: February 2024

Introduction

Although the global COVID-19 emergency ended, the real-world effects of multiple non-pharmaceutical interventions (NPIs) and the relative contribution of individual NPIs over time were poorly understood, limiting the mitigation of future potential epidemics.

Methods

Based on four large-scale datasets including epidemic parameters, virus variants, vaccines, and meteorological factors across 51 states in the United States from August 2020 to July 2022, we established a Bayesian hierarchical model with a spike-and-slab prior to assessing the time-varying effect of NPIs and vaccination on mitigating COVID-19 transmission and identifying important NPIs in the context of different variants pandemic.

Results

We found that (i) the empirical reduction in reproduction number attributable to integrated NPIs was 52.0% (95%CI: 44.4, 58.5%) by August and September 2020, whereas the reduction continuously decreased due to the relaxation of NPIs in following months; (ii) international travel restrictions, stay-at-home requirements, and restrictions on gathering size were important NPIs with the relative contribution higher than 12.5%; (iii) vaccination alone could not mitigate transmission when the fully vaccination coverage was less than 60%, but it could effectively synergize with NPIs; (iv) even with fully vaccination coverage >60%, combined use of NPIs and vaccination failed to reduce the reproduction number below 1 in many states by February 2022 because of elimination of above NPIs, following with a resurgence of COVID-19 after March 2022.

Conclusion

Our results suggest that NPIs and vaccination had a high synergy effect and eliminating NPIs should consider their relative effectiveness, vaccination coverage, and emerging variants.
Computing the impact of central clearing on systemic risk
Authors: Nowaczyk Nikolai , O'Halloran Sharyn
Published: February 2024

The paper uses a graph model to examine the effects of financial market regulations on systemic risk. Focusing on central clearing, we model the financial system as a multigraph of trade and risk relations among banks. We then study the impact of central clearing by a priori estimates in the model, stylized case studies, and a simulation case study. These case studies identify the drivers of regulatory policies on risk reduction at the firm and systemic levels. The analysis shows that the effect of central clearing on systemic risk is ambiguous, with potential positive and negative outcomes, depending on the credit quality of the clearing house, netting benefits and losses, and concentration risks. These computational findings align with empirical studies, yet do not require intensive collection of proprietary data. In addition, our approach enables us to disentangle various competing effects. The approach thus provides policymakers and market practitioners with tools to study the impact of a regulation at each level, enabling decision-makers to anticipate and evaluate the potential impact of regulatory interventions in various scenarios before their implementation.
Parental use of routines, setting limits, and child screen use during COVID-19: findings from a large Canadian cohort study
Authors: Lien Amanda , Li Xuedi , Keown-Stoneman Charles D. G. , Cost Katherine T. , Vanderloo Leigh M. , Carsley Sarah , Maguire Jonathon , Birken Catherine S.
Published: February 2024

Background

An increase in child screen time has been observed throughout the COVID-19 pandemic. Home environment and parenting practices have been associated with child screen time. The purpose of this study was to examine associations between parental use of routines, limit setting, and child screen time during the (COVID-19) pandemic to inform harm-reducing strategies to limit the potential harms ensued by excessive screen use.

Methods

A cohort study was conducted in 700 healthy children (3,628 observations) aged 0–11 years though the TARGet Kids! COVID-19 Study of Children and Families in Toronto, Canada from May 2020-May 2021. The independent variables assessed were parent-reported use of routines and setting limits. Outcomes were parent-reported child daily screen time in minutes and whether the Canadian 24-Hour screen time guideline was met, defined as 0 for <1 years, 60 or less for 1–5 years, and 120 or less for >5 years. Linear and logistic mixed-effects models were fitted using repeated measures of independent variables and outcomes with a priori stratification by developmental stages (<3, 3–4.99, ≥5 years).

Results

A total of 700 children with 3,628 observations were included in this study [mean age = 5.5 (SD = 2.7, max = 11.9) years, female = 47.6%]. Mean change in child screen time before vs. during the pandemic was +51.1 min/day and level of parental use of routines and setting limits remained stable. Lower use of routines was associated with higher child screen time (β = 4.0 min; 95% CI: 0.9, 7.1; p = 0.01) in ages ≥5 years and lower odds of meeting the screen time guideline in ages <3 years and ≥5 years (OR = 0.59; 95% CI: 0.38, 0.88; p = 0.01; OR = 0.76; 95% CI: 0.67, 0.87; p < 0.01). Lower use of limit setting was associated with higher child screen time and lower odds of meeting the screen time guideline in ages ≥5 years (β = 3.8 min; 95% CI: 0.69, 6.48; p < 0.01; OR = 0.86; 95% CI: 0.78, 0.94; p < 0.01).

Conclusions

Lower parental use of routines and limits during the COVID-19 pandemic were associated with higher screen time and lower odds of meeting the screen time guideline among school-age children. Results may help inform strategies to promote healthy screen use in this age group.
Editorial bullying: an exploration of acts impacting publication ethics and related environment
Authors: Javed Fawad , Michelogiannakis Dimitrios , Rossouw P. Emile
Published: February 2024

Bullying and misconduct in the realm of scientific and scholarly publishing have the potential to jeopardize the transparency and integrity of academic discourse. While misconduct issues among authors have been extensively discussed, the role of editors in perpetuating or mitigating such problems has garnered less attention. Scientific publishing serves as the gateway for disseminating innovative research findings globally, and the role of editors, especially Editor/s-in-chief, is pivotal in safeguarding the rigor and credibility of published research. Editor bullying and misconduct involve behaviors that undermine the scientific process, compromise research integrity, and harm the careers and wellbeing of individuals. These actions may manifest as biased decision-making, suppression of dissenting voices, or the exploitation of power dynamics in the peer review process. To address these issues, preventive and therapeutic approaches are suggested, including enhancing awareness, recognizing and mitigating exacerbating factors, and upholding professionalism. Moreover, the importance of a conflict-of-interest declaration for editors is highlighted to ensure transparency and integrity in the editorial process. The present mini-review aims to shed light on editor bullying, illuminating its gravity and the urgency to address these issues within the academic publishing domain/s. This review underscores the more subtle, yet equally significant, issue of professional misconduct in the editorial realm of scientific journals.
Upstream motion of chorus wave generation: comparisons with observations
Authors: Foster John C. , Erickson Philip J. , Omura Yoshiharu
Published: February 2024

An understanding of the development of strong very low frequency chorus elements is important in the study of the rapid MeV electron acceleration observed during radiation belt recovery events. During such events, chorus elements with long-duration (20–40 ms), strong (|Bw| 0.5–2.0 nT) subpackets with smoothly varying frequency and phase capable of producing nonlinear energy gain of 1%–2% for multi-MeV seed electrons. For such strong chorus elements, we examine the consequences of an upstream motion of the chorus wave generation region using Van Allen Probes observations and nonlinear theory. For a given upstream velocity, vs, resonant electron energy (50–350 keV) and pitch angle (105–115 deg) are uniquely determined for each wave frequency. We examine the effect of an upstream vs on the inhomogeneity factor that controls wave growth. For steadily increasing upstream motion as the chorus element evolves, vs/c ranging over [-0.001, −0.065], nonlinear wave growth takes place at ≥ 50% of the theoretical maximal value during the development of the observed strong subpackets. For the cases examined, resonant electron energies and pitch angles closely match those of the observed injected electron flux enhancements responsible for chorus development and the nonlinear acceleration of MeV radiation belt electrons.
Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis
Authors: Aldridge Chad M. , Armstrong Nicole D. , Sunmonu N. Abimbola , Becker Christopher , Palakshappa Deepak , Lindgren Arne G. , Pedersen Annie , Stanne Tara M. , Jern Christina , Maguire Jane , Hsu Fang-Chi , Keene Keith L. , Sale Michele , Irvin Marguerite R. , Worrall Bradford B.
Published: February 2024

Introduction

Stroke is a leading cause of death and disability worldwide. Recurrent strokes are seven times more lethal than initial ones, with 54% leading to long-term disability. Substantial recurrent stroke risk disparities exist among ancestral groups. Notably, Africans face double the risk and higher fatality rates compared to Europeans. Although genetic studies, particularly GWAS, hold promise for uncovering biological insights into recurrent stroke, they remain underexplored. Our study addresses this gap through meta-analyses of recurrent stroke GWAS, considering specific ancestral groups and a combined approach.

Methods

We utilized four independent study cohorts for African, European, and Combined ancestry recurrent stroke GWAS with genotyping, imputation, and strict quality control. We harmonized recurrent stroke phenotype and effect allele estimates across cohorts. The logistic regression GWAS model was adjusted for age, sex, and principal components. We assessed how well genetic risk of stroke informs recurrent stroke risk using Receiver Operating Characteristic (ROC) curve analysis with the GIGASTROKE Consortium's polygenic risk scores (PRS).

Results

Harmonization included 4,420 participants (818 African ancestry and 3,602 European ancestry) with a recurrent stroke rate of 16.8% [median age 66.9 (59.1, 73.6) years; 56.2% male]. We failed to find genome-wide significant variants (p < 5e−8). However, we found 18 distinct suggestive (p < 5e−6) genetic loci with high biological relevance consistent across African and European ancestries, including PPARGC1B, CCDC3, OPRL1, and MYH11 genes. These genes affect vascular stenosis through constriction and dilation. We also observed an association with SDK1 gene, which has been previous linked with hypertension in Nigerian and Japanese populations). ROC analysis showed poor performance of the ischemic stroke PRS in discriminating recurrent stroke status (area under the curve = 0.48).

Discussion

Our study revealed genetic associations with recurrent stroke not previously associated with incident ischemic stroke. We found suggestive associations in genes previously linked with hypertension. We also determined that knowing the genetic risk of incident stroke does currently not inform recurrent stroke risk. We urgently need more studies to understand better the overlap or lack thereof between incident and recurrent stroke biology.