bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S4 from Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study
Authors: Zhang Minghui , Ru Meng , Zhang Jingning , Wang Ziqiao , Lu Jiayun , Butler Kenneth R. , Chatterjee Nilanjan , Couper David J. , Prizment Anna E. , Soori Mehrnoosh M. , Visvanathan Kala , Zahnow Cynthia A. , Joshu Corinne E. , Platz Elizabeth A.
Published: February 2025

Supplementary Table S4: The association between current ethanol intake and breast cancer incidence restricted to those had a health insurance, stratified by race in ARIC (1990-2015)
Supplementary Table S2 from Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study
Authors: Zhang Minghui , Ru Meng , Zhang Jingning , Wang Ziqiao , Lu Jiayun , Butler Kenneth R. , Chatterjee Nilanjan , Couper David J. , Prizment Anna E. , Soori Mehrnoosh M. , Visvanathan Kala , Zahnow Cynthia A. , Joshu Corinne E. , Platz Elizabeth A.
Published: February 2025

Supplementary Table S2: The association between 313-SNP PRS and breast cancer incidence stratified by maternal history of breast cancer and by race in ARIC (1990-2015)
Figure S10 from A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity against Prostate Cancer
Authors: Phung Shee Kwan , Zorko Nicholas A. , Soignier Yvette , Waller Rhett L. , Shackelford Madison , Walker Joshua T. , Nelson Trygve D. , Selleck Carly , Bendzick Laura E. , Kotz Laura E. , Kile Quinlan M. , Bozicevich Asha J. , Miller Sarah E. , Khaw Melissa , Shetty Mihir , Hinderlie Peter , Ehrhardt Michael , Li Yingming , Luo Xianghua , Dehm Scott M. , Antonarakis Emmanuel S. , Kennedy Philippa R. , Miller Jeffrey S. , Felices Martin
Published: February 2025

In vivo study results.
Figure S1 from A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity against Prostate Cancer
Authors: Phung Shee Kwan , Zorko Nicholas A. , Soignier Yvette , Waller Rhett L. , Shackelford Madison , Walker Joshua T. , Nelson Trygve D. , Selleck Carly , Bendzick Laura E. , Kotz Laura E. , Kile Quinlan M. , Bozicevich Asha J. , Miller Sarah E. , Khaw Melissa , Shetty Mihir , Hinderlie Peter , Ehrhardt Michael , Li Yingming , Luo Xianghua , Dehm Scott M. , Antonarakis Emmanuel S. , Kennedy Philippa R. , Miller Jeffrey S. , Felices Martin
Published: February 2025

PSMA abundance on C4-2 WT and C4-2 PSMA KO.
Table S1 from Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma
Authors: McGeary Meaghan K. , Damsky William , Daniels Andrew J. , Lang Sabine M. , Xu Qingji , Song Eric , Huet-Calderwood Clotilde , Lou Hua Jane , Paradkar Sateja , Micevic Goran , Kaech Susan M. , Calderwood David A. , Turk Benjamin E. , Yan Qin , Iwasaki Akiko , Bosenberg Marcus W.
Published: February 2025

List of primers used to perform RT-qPCR on YUDOSO cells related to Figure S6.
Figure S3 from Combination CXCR4 and PD-1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma
Authors: Morita Satoru , Lei Pin-Ji , Shigeta Kohei , Ando Tomofumi , Kobayashi Tatsuya , Kikuchi Hiroto , Matsui Aya , Huang Peigen , Pittet Mikael J. , Duda Dan G.
Published: February 2025

Supplementary Figure S3
Table S3 from TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
Authors: Sun Yi , Maggs Luke , Panda Apekshya , Wright Samuel J. , Cicerchia Angelina M. , Jenney Anne , Perricone Matthew D. , Mills Caitlin E. , Cattaneo Giulia , Ventin Marco , Chen Feng , Rasmussen Martin Q. , Miranda Alex , Revach Or-Yam , Fang Jacy , Fu Amina , Bowling Peter J. , Sharova Tatyana , Lawless Aleigha , Sorger Peter K. , Bardeesy Nabeel , Wang Xinhui , Flaherty Keith T. , Boland Genevieve M. , Mehta Arnav , Sade-Feldman Moshe , Ferrone Cristina R. , Jenkins Russell W.
Published: February 2025

PDOTS patient data (accompanying Fig. 3)
Table S2 from TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
Authors: Sun Yi , Maggs Luke , Panda Apekshya , Wright Samuel J. , Cicerchia Angelina M. , Jenney Anne , Perricone Matthew D. , Mills Caitlin E. , Cattaneo Giulia , Ventin Marco , Chen Feng , Rasmussen Martin Q. , Miranda Alex , Revach Or-Yam , Fang Jacy , Fu Amina , Bowling Peter J. , Sharova Tatyana , Lawless Aleigha , Sorger Peter K. , Bardeesy Nabeel , Wang Xinhui , Flaherty Keith T. , Boland Genevieve M. , Mehta Arnav , Sade-Feldman Moshe , Ferrone Cristina R. , Jenkins Russell W.
Published: February 2025

PDOTS patient data (accompanying Fig. 2)
Table S4 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Table S4
Figure S4 from TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
Authors: Sun Yi , Maggs Luke , Panda Apekshya , Wright Samuel J. , Cicerchia Angelina M. , Jenney Anne , Perricone Matthew D. , Mills Caitlin E. , Cattaneo Giulia , Ventin Marco , Chen Feng , Rasmussen Martin Q. , Miranda Alex , Revach Or-Yam , Fang Jacy , Fu Amina , Bowling Peter J. , Sharova Tatyana , Lawless Aleigha , Sorger Peter K. , Bardeesy Nabeel , Wang Xinhui , Flaherty Keith T. , Boland Genevieve M. , Mehta Arnav , Sade-Feldman Moshe , Ferrone Cristina R. , Jenkins Russell W.
Published: February 2025

Supplemental Figure S4 | Supporting data for ex vivo profiling of PD-1 blockade and TBK1 inhibition in combination with B7-H3.CAR-T cells using PDOTS.
Table S3 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Table S3
Figure S3 from TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
Authors: Sun Yi , Maggs Luke , Panda Apekshya , Wright Samuel J. , Cicerchia Angelina M. , Jenney Anne , Perricone Matthew D. , Mills Caitlin E. , Cattaneo Giulia , Ventin Marco , Chen Feng , Rasmussen Martin Q. , Miranda Alex , Revach Or-Yam , Fang Jacy , Fu Amina , Bowling Peter J. , Sharova Tatyana , Lawless Aleigha , Sorger Peter K. , Bardeesy Nabeel , Wang Xinhui , Flaherty Keith T. , Boland Genevieve M. , Mehta Arnav , Sade-Feldman Moshe , Ferrone Cristina R. , Jenkins Russell W.
Published: February 2025

Supplemental Figure S3 | Supporting data for ex vivo profiling of B7-H3.CAR-T cells using PDOTS.
Figure S2 from TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
Authors: Sun Yi , Maggs Luke , Panda Apekshya , Wright Samuel J. , Cicerchia Angelina M. , Jenney Anne , Perricone Matthew D. , Mills Caitlin E. , Cattaneo Giulia , Ventin Marco , Chen Feng , Rasmussen Martin Q. , Miranda Alex , Revach Or-Yam , Fang Jacy , Fu Amina , Bowling Peter J. , Sharova Tatyana , Lawless Aleigha , Sorger Peter K. , Bardeesy Nabeel , Wang Xinhui , Flaherty Keith T. , Boland Genevieve M. , Mehta Arnav , Sade-Feldman Moshe , Ferrone Cristina R. , Jenkins Russell W.
Published: February 2025

Supplementary Figure S2 | Supporting data for the In vitro characterization and efficacy of B7-H3.CAR-T cells.
Table S1 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Table S1
Fig. S9 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Fig. S9 | scRNA-seq analysis of CD4+ TIL population.
Fig. S5 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Fig. S5 | Characterization of neoantigen-specific CD4+ TIL clones.
Fig. S4 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Fig. S4 | Neoantigen specificity of CD4+ TIL clones.
Fig. S3 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Fig. S3 | UTE07 bulk TIL responses to the identified neoantigens.
Fig. S1 from Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer
Authors: Fusagawa Minami , Tokita Serina , Murata Kenji , Mariya Tasuku , Umemoto Mina , Sugita Shintaro , Matsuo Kazuhiko , Hirohashi Yoshihiko , Saito Tsuyoshi , Kanaseki Takayuki , Torigoe Toshihiko
Published: February 2025

Fig. S1 | IHC of endometrial cancer tissues.
Figure S1 from The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment
Authors: Tsuge Ayaka , Watanabe Sho , Kawazoe Akihito , Togashi Yosuke , Itahashi Kota , Masuda Mari , Sai Atsuo , Takei Shogo , Muraoka Hiromi , Ohkubo Shuichi , Sugiyama Daisuke , Yan Yue , Fukuoka Shota , Doi Toshihiko , Shitara Kohei , Koyama Shohei , Nishikawa Hiroyoshi
Published: February 2025

Pimitespib treatment does not significantly alter the infiltration of myeloid cell populations in gastric cancers. (A, B). Representative multiple IHC images of T cell subsets (A), and myeloid subsets (B) before pimitespib treatment with or without nivolumab. (C). A summary of the frequencies of CD14+ cells (monocyte/macrophage), HLA-DR+ cells, CD14+CD206+ cells, and CD14+HLA-DR+ cells. The data are presented as a total of six fields per biopsy specimen from five patients. Scale bars, 50 μm.
Supplementary Table S3 from T Cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL1 and TNFα Inflammation
Authors: Cho Nam Woo , Guldberg Sophia M. , Nabet Barzin Y. , Yu Jie Zeng , Kim Eun Ji , Hiam-Galvez Kamir J. , Yee Jacqueline L. , DeBarge Rachel , Tenvooren Iliana , Ashitey Naa Asheley , Lynce Filipa , Dillon Deborah A. , Rosenbluth Jennifer M. , Spitzer Matthew H.
Published: February 2025

Supplementary Data Table S3
Supplementary Figure S8 from T Cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL1 and TNFα Inflammation
Authors: Cho Nam Woo , Guldberg Sophia M. , Nabet Barzin Y. , Yu Jie Zeng , Kim Eun Ji , Hiam-Galvez Kamir J. , Yee Jacqueline L. , DeBarge Rachel , Tenvooren Iliana , Ashitey Naa Asheley , Lynce Filipa , Dillon Deborah A. , Rosenbluth Jennifer M. , Spitzer Matthew H.
Published: February 2025

Supplementary Data Figure S8
Supplementary Figure S2 from T Cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL1 and TNFα Inflammation
Authors: Cho Nam Woo , Guldberg Sophia M. , Nabet Barzin Y. , Yu Jie Zeng , Kim Eun Ji , Hiam-Galvez Kamir J. , Yee Jacqueline L. , DeBarge Rachel , Tenvooren Iliana , Ashitey Naa Asheley , Lynce Filipa , Dillon Deborah A. , Rosenbluth Jennifer M. , Spitzer Matthew H.
Published: February 2025

Supplementary Data Figure S2
Table S1 from Targeting of Tumoral NAC1 Mitigates Myeloid-Derived Suppressor Cell–Mediated Immunosuppression and Potentiates Anti–PD-1 Therapy in Ovarian Cancer
Authors: Dong Shunli , Ye Cong , Li Bin , Lv Fanglin , Zhang Lu , Yang Shumin , Wang Fang , Zhu Mingxian , Zhou Mingxuan , Guo Fanfan , Li Zhenyun , Peng Lei , Ji Cheng , Lu Xialiang , Cheng Yan , Ren Xingcong , Chen Youguo , Zhou Jinhua , Yang Jinming , Zhang Yi
Published: February 2025

Table S1. The details of the clinical sample for IHC analysis.
Supplementary Figure 2 from Inflammatory Stress Determines the Need for Chemotherapy in Patients with HER2-Positive Esophagogastric Adenocarcinoma Receiving Targeted Therapy and Immunotherapy
Authors: Tintelnot Joseph , Paschold Lisa , Goekkurt Eray , Schultheiss Christoph , Matschl Urte , Santos Cruz Mariana , Bauer Marcus , Wickenhauser Claudia , Thuss-Patience Peter , Lorenzen Sylvie , Ettrich Thomas J. , Riera-Knorrenschild Jorge , Jacobasch Lutz , Kretzschmar Albrecht , Kubicka Stefan , Al-Batran Salah-Eddin , Reinacher-Schick Anke , Pink Daniel , Bokemeyer Carsten , Sinn Marianne , Lindig Udo , Hinke Axel , Hegewisch-Becker Susanna , Stein Alexander , Binder Mascha
Published: February 2025

Supplementary Figure 2: Emotional distress and tumor burden do not explain the systemic inflammatory signature.
Supplementary Figure S3 from Targeting of Tumoral NAC1 Mitigates Myeloid-Derived Suppressor Cell–Mediated Immunosuppression and Potentiates Anti–PD-1 Therapy in Ovarian Cancer
Authors: Dong Shunli , Ye Cong , Li Bin , Lv Fanglin , Zhang Lu , Yang Shumin , Wang Fang , Zhu Mingxian , Zhou Mingxuan , Guo Fanfan , Li Zhenyun , Peng Lei , Ji Cheng , Lu Xialiang , Cheng Yan , Ren Xingcong , Chen Youguo , Zhou Jinhua , Yang Jinming , Zhang Yi
Published: February 2025

Figure S3. the bioinformatics analysis of human ovarian tumor samples from TCGA data and Kaplan–Meier survival curves of orthotopic immunocompetent C57BL/6 tumor-bearing mice.
Supplementary Figure S2 from Targeting of Tumoral NAC1 Mitigates Myeloid-Derived Suppressor Cell–Mediated Immunosuppression and Potentiates Anti–PD-1 Therapy in Ovarian Cancer
Authors: Dong Shunli , Ye Cong , Li Bin , Lv Fanglin , Zhang Lu , Yang Shumin , Wang Fang , Zhu Mingxian , Zhou Mingxuan , Guo Fanfan , Li Zhenyun , Peng Lei , Ji Cheng , Lu Xialiang , Cheng Yan , Ren Xingcong , Chen Youguo , Zhou Jinhua , Yang Jinming , Zhang Yi
Published: February 2025

Figure S2. Tumoral expression of NAC1 promotes ovarian cancer progression in immunocompetent mice.
Supplementary Figure S4 from Hyperthermic Intrathoracic Chemotherapy Modulates the Immune Microenvironment of Pleural Mesothelioma and Improves the Impact of Dual Immune Checkpoint Inhibition
Authors: Hao Yameng , Gkasti Aspasia , Managh Amy J. , Dagher Julien , Sifis Alexandros , Tiron Luca , Chriqui Louis-Emmanuel , Marie Damien N. , De Souza Silva Olga , Christodoulou Michel , Peters Solange , Joyce Johanna A. , Krueger Thorsten , Gonzalez Michel , Abdelnour-Berchtold Etienne , Sempoux Christine , Clerc Daniel , Teixeira-Farinha Hugo , Hübner Martin , Meylan Etienne , Dyson Paul J. , Cavin Sabrina , Perentes Jean Y.
Published: February 2025

Supplementary Figure S4: Effect of HITOC on CD4 T cell infiltration in tumors.
Data from The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment
Authors: Tsuge Ayaka , Watanabe Sho , Kawazoe Akihito , Togashi Yosuke , Itahashi Kota , Masuda Mari , Sai Atsuo , Takei Shogo , Muraoka Hiromi , Ohkubo Shuichi , Sugiyama Daisuke , Yan Yue , Fukuoka Shota , Doi Toshihiko , Shitara Kohei , Koyama Shohei , Nishikawa Hiroyoshi
Published: February 2025

Abstract
Regulatory T (Treg) cells play key roles in cancer immunity by suppressing a range of antitumor immune responses and contributing to resistance to PD-1 blockade therapy. Given their critical roles in self-tolerance, local control of immunosuppression by Treg cells, such as in the tumor microenvironment, has been intensively studied. Inhibition of HSP90, a chaperone with vital roles in regulating proteostasis in cancer cells, impedes cancer progression by interrupting oncogenic signaling pathways and potentially modulating antitumor immunity, but we have very little mechanistic insight into these immune modulatory effects. In this study, we show that the number of Treg cells is selectively reduced by the HSP90 inhibitor pimitespib in animal models and patients with gastric cancer in a clinical trial (EPOC1704). Pimitespib reduced the highly immunosuppressive human FOXP3high effector Treg cells by inhibiting their proliferation and decreasing their expression of effector molecules, which improved the priming and activation of antigen-specific CD8+ T cells. Mechanistic studies revealed that pimitespib selectively degraded STAT5, a key transducer of the IL2 signaling pathway, which is essential for Treg cell development and maintenance, and consequently compromised FOXP3 expression, leading to selective impairment of immunosuppression in the tumor microenvironment by Treg cells. Thus, pimitespib treatment combined with PD-1 blockade exhibited a far stronger antitumor effect than either treatment alone in animal models. Through these data, we propose that HSP90 inhibition is a promising therapeutic option for Treg cell–targeted cancer immunotherapy.
Addressing Health Disparities in Hematologic Malignancies: from Genes to Outreach
Authors: Flowers Christopher R. , Anantha Rachel W. , Leautaud Veronica , Desai Pinkal , Donald Chancellor E. , Hildebrandt Michelle A.T. , Koff Jean L. , Tamimi Rulla M. , Cozen Wendy , Nze Chijioke , Melnick Ari M.
Published: February 2025

Hematologic malignancies exhibit disparities in risk and outcomes across populations. A systematic review to identify prospective studies addressing disparities among patients with hematologic malignancies with an intervention or analysis at any level in the “Cells-to-Society” model identified few studies and demonstrated literature gaps, which experts have supplemented with relevant citations. This review presents current research on diagnosis, treatment, and survival disparities and explores the roles of biology, cancer centers, community outreach, patient advocacy, and policies. Emphasis is placed on multilevel collaborative approaches to promote equity in healthcare delivery and improve survival.

Significance:

This review underscores our shared responsibility to champion multidimensional strategies rooted in basic and translational science, community involvement, and societal responsiveness for a meaningful impact. Unifying themes include the need to enhance collaborative infrastructure to engage laboratory researchers, epidemiologists, data scientists, clinicians, patients, community leaders, and policymakers; patient-level support services; outreach, education, and navigation for patients at the community level; recruitment and retention of underrepresented groups in the healthcare and research workforce; and funding for these efforts.
Supplementary Figure 8 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Authors: Longakit Anne Nathalie , Urtatiz Oscar , Luty Amy , Zhang Christina , Hess Chloe , Yoo Alyssa , Bourget Hannah , Van Raamsdonk Catherine D.
Published: February 2025

Supplementary Figure 8
Supplementary Figure 12 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Authors: Longakit Anne Nathalie , Urtatiz Oscar , Luty Amy , Zhang Christina , Hess Chloe , Yoo Alyssa , Bourget Hannah , Van Raamsdonk Catherine D.
Published: February 2025

Supplementary Figure 12
Supplementary Figure 10 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Authors: Longakit Anne Nathalie , Urtatiz Oscar , Luty Amy , Zhang Christina , Hess Chloe , Yoo Alyssa , Bourget Hannah , Van Raamsdonk Catherine D.
Published: February 2025

Supplementary Figure 10
Figure 6 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Authors: Longakit Anne Nathalie , Urtatiz Oscar , Luty Amy , Zhang Christina , Hess Chloe , Yoo Alyssa , Bourget Hannah , Van Raamsdonk Catherine D.
Published: February 2025

Transcriptomic analysis of uveal melanoma, intradermal melanoma, and sparse pigment tumors. A and B, All samples were included in unsupervised clustering by gene expression, regardless of the Nf1 genotype or tumor type. Principal component analysis (A) and the sample distance dendrogram (B) show that the three different tumor types cluster separately from each other. In B, the two sparse pigment tumors (shown in Fig. 2I and M) from the same mouse are indicated with asterisks. C, Same principal component analysis plot as shown in A but now color coded to show the Nf1 genotypes. There was no obvious clustering by Nf1 genotype within tumor types. D and E, Volcano plots of differential gene expression in Nf1flox/+ vs. Nf1 +/+ intradermal melanomas (D) and uveal melanomas (E). F and G, Top terms found in GO analysis of the DE genes in intradermal melanoma (F) and uveal melanoma (G). KEGG, Kyoto Encyclopedia of Genes and Genomes.
Figure 5 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Authors: Longakit Anne Nathalie , Urtatiz Oscar , Luty Amy , Zhang Christina , Hess Chloe , Yoo Alyssa , Bourget Hannah , Van Raamsdonk Catherine D.
Published: February 2025

Nf1 loss increased the size of uveal melanoma tumors in mice expressing oncogenic GNAQ. A, H&E-stained sections of representative eyes of the indicated genotypes. B, IHC to determine whether the excess pigmented tissue in eyes was uveal melanoma, using IHC to examine expression of S100B (for melanocytes, left) or RPE65 (for retinal pigment epithelium “RPE,” right). The excess tissue was S100B-positive, and the RPE was a normal, single-layered epithelium. C, Quantification of the area of uveal melanoma in Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1flox/+ vs. Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1 +/+ eyes. All eyes examined were affected. There was a significant increase in area in the Nf1flox/+ eyes. D, 6-week Plp1-creERT/+; Rosa26-fs-tdTomato/+ eye one week following injection with tamoxifen. Plp1-creERT induced tomato expression (red) in cells in the uveal tract, including the iris, ciliary body, and choroid (shown in enlargements, right). Sections were counterstained with 4',6-diamidino-2-phenylindole (DAPI; blue).
Figure 4 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Authors: Longakit Anne Nathalie , Urtatiz Oscar , Luty Amy , Zhang Christina , Hess Chloe , Yoo Alyssa , Bourget Hannah , Van Raamsdonk Catherine D.
Published: February 2025

Intradermal melanoma tumorigenesis was accelerated by Nf1 loss in mice expressing oncogenic GNAQ. A, Graph of intradermal tumor volumes at endpoint. Each point on the graph represents a different tumor. There was no significant difference between the average tumor volume in Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1flox/+ and Plp1-creERT/+; R26-fs-GNAQQ209L/+; +/+ mice because mice were euthanized shortly after tumor discovery. Error bars represent the SEM. B, Graph of intradermal tumor volumes at endpoint, showing the combined tumor load per mouse on the y axis. Each dot represents a different mouse. The x axis indicates when each mouse was euthanized. C, Percent weight loss in the second cohort of mice over time in mice of the indicated genotypes. D, Graph of sparse pigment tumor volumes at endpoint. Each point on the graph represents a different tumor. There was no significant difference between the average tumor volumes in Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1flox/+ and Plp1-creERT/+; R26-fs-GNAQQ209L/+; +/+ mice because mice were euthanized shortly after tumor discovery. Error bars represent the SEM. E, Kaplan–Meier plot of tumor-free survival in Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1flox/+ mice vs. Plp1-creERT/+; R26-fs-GNAQQ209L/+; +/+ mice. There was a significantly decreased tumor-free survival in Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1flox/+ mice. n.s., not significant.
Progressive Retinal Degeneration and Juvenile Nephronophthisis in a Patient with Autosomal Recessive Ciliopathy: A Case Report
Authors: Pericak Jakob M. , Chin Eric K. , Almeida David R.P.
Published: February 2025

Introduction: Inherited retinal diseases, particularly ciliopathies, often lead to irreversible blindness and are frequently accompanied by systemic manifestations such as nephronophthisis. Current treatment options are limited, necessitating the exploration of supplementary strategies to slow disease progression. Case Presentation: We present a rare case from a retinal surgery clinic involving a 30-year-old male with autosomal recessive retinitis pigmentosa (ARRP) and juvenile nephronophthisis. Comprehensive ocular and genetic evaluations were conducted, followed by the implementation of nutritional interventions aimed at mitigating multi-systemic effects. Genetic testing revealed pathogenic variants in CEP83, PCARE, and VPS13B genes, confirming the diagnosis of ARRP. Nutritional strategies, including omega-3 fatty acids, antioxidants, and tailored dietary modifications for renal health, were integrated alongside standard medical care. These interventions contributed to the stabilization of retinal degeneration and improved management of end-stage renal disease. Conclusion: Integrating personalized nutritional strategies into the management of ciliopathies can enhance patient out-comes by addressing both ocular and systemic manifestations. These findings underscore the need for policy development around nutritional education and support for patients with inherited ciliopathies.
Tarifação social no consumo residencial de água
Authors: Andrade Thompson A. , Lobão Waldir J. A.
Published: February 2025

Este artigo examina as limitações e os efeitos da adoção de uma estrutura tarifaria por uma empresa prestadora de serviços de utilidade pública que utiliza um sistema de subsídios cruzados para financiar uma tarifa mais baixa cobrada aos usuários pobres. Os exercicios de simulação tarifária são feitos usando-se tarifas diferenciadas segundo a classificação social dos consumidores, sendo medidos os efeitos que o subsídio provoca em termos da quantidade demandada e do seu impacto sobre o nível de bem-estar dos usuários. Na parte final do artigo, mostra-se como este tipo de estrutura tarifária pode ser convertido naquele no qual as tarifas são estabelecidas para blocos de quantidades consumidas do serviço, a maneira tradicional de cobrar os serviços de utilidade pública.
Global warming impacts on Brazilian agriculture: estimates of the Ricardian model
Authors: Sanghi Apurva , Alves Denisard , Evenson Robert , Mendelsohn Robert
Published: February 2025

This paper estimates the impact of climate change on agriculture in Brazil using the Ricardian approach. Our findings indicate that the net impact of climate change on Brazilian agriculture is negative, although there are varying regional consequences. March and September temperature and precipitation effects are positive, but are outweighed by the more negative December and June effects. The Center-West region is most negatively affected, whereas the South benefits mildly from warming.
Credit channel without the LM curve
Authors: Chu Victorio Y. T. , Nakane Marcio I.
Published: February 2025

This paper extends Bernanke and Blinder (1988)'s macroeconomic model of credit channel to an environment where the monetary authority has control over a short-term interest rate. The comparative statics regarding changes in the market interest rate, in the required reserve ratio over bank deposits, and in the risk of public bonds are highlighted.
Measuring Representativeness in Clinical Trials
Authors: Sanyi Allen , Byiringiro Samuel , Dabiri Sanaz , Jacobson Mireille , Boyd Amanda , Ogunniyi Modele O. , Morris Alanna A. , Kohn Rachel , Dickert Neal W. , Lane-Fall Meghan B. , Lewis Eldrin F. , Halpern Scott D. , Fanaroff Alexander C.
Published: February 2025

Representativeness in randomized clinical trials remains a critical concern, affecting the external validity of trial results, equitable access to the risks and benefits of research participation, and public trust in clinical research. Although representative participation by members of groups traditionally underrepresented in clinical trials is just a surrogate for true diversity, equity, inclusion, and belonging in clinical trials, it can be quantified, allowing stakeholders to add empirical rigor to diversity, equity, inclusion, and belonging efforts. Multiple ways to measure representativeness have been proposed, including the participation-to-prevalence ratio, raw participation proportions or numbers for relevant subgroups, and enrollment fraction for relevant subgroups. These methods have strengths and weaknesses and may be appropriate to report in certain circumstances, depending on why stakeholders seek to assess representativeness. Stakeholders—including regulatory agencies, journal editors, clinical trial investigators, and trial sponsors—may use quantitative measures of representativeness to establish trial enrollment standards, monitor equitable participation in ongoing trials, and condition funding or drug or device approval on achieving specific representativeness targets. However, using quantitative measures of representativeness in this way could have unintended consequences, including researchers “gaming” recruitment strategies to meet target numbers, overlooking nuanced variations within communities, and potentially incentivizing problematic and exploitative recruitment strategies. Although no single method of measuring representativeness offers a comprehensive solution for increasing diversity, equity, inclusion, and belonging in all randomized clinical trials, a carefully designed, multifaceted approach to measuring representativeness may provide stakeholders with useful perspectives for measuring progress in increasing the diversity of clinical trial participation. For stakeholders seeking a single number to assess the representativeness of a trial enrolling patients with a disease state with well-delineated demographics, the participation-to-prevalence ratio is ideal; however, for a more nuanced view of representativeness, the combination of enrollment fraction in subgroups of relevance plus a full report of the demographics of patients approached for enrollment may be more appropriate.
Morphology and phylogeny reveal Gymnopus pseudoandrosaceus sp. nov. (Agaricales, Basidiomycota) from Southwest China
Authors: DENG CHUN-YING , WANG WANG-KUN , LI JI-PENG , ANTONÍN VLADIMÍR
Published: February 2025

Gymnopus pseudoandrosaceus sp. nov. is described from Southwest China. It is characterized by a brown marasmioid pileus, a shining black stipe, and abundant rhizomorphs, a pileipellis in the form of a cutis with encrusted pigments and without broom cells, and cheilocystidia with apical projections. The phylogenetic analysis placed the new species within the Gymnopus sect. Androsacei clade with well-supported lineages across Impudicae, Levipedes, Gymnopus, Androsacei, and Paragymnopus. Strong bootstrap values affirm these relationships, with notable diversity in Gymnopus indicating potential adaptive radiation. The pileipellis lacking broom cells is a rather unique feature in this section. Detailed morphological descriptions, basidiomata photographs, microscopic structure images, and phylogenetic analysis results are provided.
A new narrower circumscription and a nomenclatural synopsis for Calea subg. Meyeria (Asteraceae: Neurolaeneae)
Authors: BUENO VINICIUS R. , REIS-SILVA GENILSON A. , NAKAJIMA JIMI N. , GOSTE MORGAN R. , HEIDEN GUSTAVO
Published: February 2025

The studies on Calea subg. Meyeria (Neurolaeneae, Asteraceae), a group from open vegetation in Southeastern South America, recently resulted in the description of novel species and nothospecies. Continued progress on the nomenclatural and taxonomic studies of this subgenus is presented here. A comprehensive bibliography for species described in this section was compiled and revised to allow the proposition of nomenclatural changes. All type specimens were consulted either in person or using high-resolution digital images. Based on these efforts, we propose a narrower circumscription of Calea subg. Meyeria, altering the number of accepted taxa assigned to it from 15 to 9. The subgenus is here proposed to be characterized morphologically by shrubs with a cymose capitulescence, capitula with four or more foliaceous outer phyllaries and cypsela longer than the pappus. As here defined, it comprises eight species (C. funkiana, C. marginata, C. myrtifolia, C. parvifolia, C. phyllolepis, C. pruskiana, C. subintegerrima, and C. triantha) and one nothospecies (C. × parviantha). Altogether, we synonymize four names; propose lectotypifications for two names; recognize three new isolectotypes; and provide corrections for type specimen collection data from six taxa, including collector names, collection date, and locality.
A new trasandean species of the genus Tigridania Kaye, 1918 (Lepidoptera: Erebidae: Arctiinae: Arctiini: Euchromiina) from Colombia
Authors: ALZATE-CANO JULIAN DAVID , WOLFF MARTA , LAGUERRE MICHEL
Published: February 2025

During curatorial work at the Entomological Collection of the Universidad de Antioquia (Medellín, Colombia), we discovered a recently collected pair of Euchromiina in copula (Fig. 1B) in the department of Antioquia, Colombia (Fig. 1A). It was a large and robust species, with translucent wings and a striking yellow and red abdomen. This species resembled Autochloris thyestes Druce, 1883, described from Ecuador, but certain details and characteristics suggested a more complex situation. After reviewing recent literature, we found the revision of the genus Tigridania Kaye, 1918 by Grados & Ramírez (2021). The genus Tigridania is monotypic, containing only the type species Tigridania quadricincta Kaye, 1918, described from the Rio Ucayali in the upper Amazon. The species Isanthrene flavizonata Gaede, 1926 which is also a large and robust species with translucent wings, was synonymized with T. quadricincta, by Grados & Ramirez (2021). However in T. quadricincta the abdomen is creamy-yellow with broad black bands and a black tip, markedly different from our species. On the other hand, the male genitalia and secondary sexual characteristics are very similar to those of the type species. Therefore, we have decided to describe it below as a new species, under the name Tigridania magdalenae sp. nov.
Revision of the genus Stenoscelis Wollaston (Coleoptera: Curculionidae: Cossoninae) of Japan
Authors: INOUE SHÛGO
Published: February 2025

The Japanese species of the genus Stenoscelis Wollaston, 1861 are revised. Nine species, S. acutipennis Zherikhin, 1991, S. brevithoracicus Inoue sp. nov., S. cavirostris Inoue sp. nov., S. longisetosus Konishi, 1956, S. aceri Konishi, 1962, S. matobai Inoue sp. nov., S. reniformis Inoue sp. nov., S. gracilitarsis Wollaston, 1873, and S. ogasawarensis Inoue sp. nov., are recognized. Stenoscelis cryptomeriae Konishi, 1962 syn. nov. is a new junior synonym of S. longisetosus Konishi, 1956. All species are described or redescribed, and a key to the Japanese species is presented.
Understanding Nocturnally-driven Extreme Precipitation Events over Lake Victoria in a Convection-Permitting Model
Authors: Glazer Russell H. , Coppola Erika , Giorgi Filippo
Published: February 2025

Each year on the order of 1000 fishers are lost on Lake Victoria (LV) due to hazardous weather and intense nighttime thunderstorms making LV one of the most hazardous lakes in the world. In this study we present a 10-year (2006-2015) convection-permitting (3km grid-spacing) simulation of the Lake Victoria Basin (LVB) using the non-hydrostatic version of the regional model RegCM (RegCM-NH). We construct composites of three different types of events over the lake during nighttime and early morning hours: 1) Dry events in which no rain fell over the lake, 2) Normal events in which rainfall over LV matches that of the annual mean, and 3) Extreme events in which rainfall exceeded the 99.99th percentile. In Extreme, an enhanced land breeze takes place along the western side of LV, resulting from convection along the high terrain to the west of the lake in the early evening and nighttime hours which cool the boundary layer through evaporative cooling, cold pools, and prolonged radiatively driven cooling. Cold pools are identified as playing a role in the triggering of convection over the lake, and/or the propagation of convection during Extreme events. Greater dynamical forcing in the lead up to an event exists in Extreme relative to Normal, while convective instability over LV is similar in Extreme and Normal. Dry events exhibit hazardous wind conditions over the lake occurring outside the main rainy season.
The “logic” of diagrams in the Spherics of Theodosios
Authors: Sidoli Nathan
Published: February 2025

This paper provides a semiotic reading of the relationship between the text and the diagram in Theodosios’ Spherics, focusing on Sph. II.4 and II.5. This analysis provides a detailed explanation of what the inferences in the text imply for the mathematical objects and for the diagram, and argues that these are independent. It argues that the objects, and in particular the letters that name them, function in semiotically different ways in the text and in the diagram, but that the role of the objects in the text is meant to be mathematically and logically prior. It then argues that many places in which the diagram seems to contain information that is not included in the text are best explained by errors of the editing process or of the transmission; but that there do remain a few places that require direct inferences from the diagram.
When to Use Counterfactuals in Causal Historiography: Methods for Semantics and Inference
Authors: Jeong Tay
Published: February 2025

According to the interventionist framework of actual causality, causal claims in history are ultimately claims about special types of functional dependencies between variables, which consist not only of actual events but also of corresponding counterfactual states of affairs. Instead of advocating the methodological use of counterfactuals tout court, we propose specific circumstances in historical writing where counterfactual reasoning comes in most handy. At the level of semantics, that is, the specification of the variables and their possible values, an explicit specification of the latent contrast classes becomes particularly useful in situations where one may be prompted to take an event that is pre-empted by the antecedent of interest as its proper causal contrast. At the level of inference, we argue that cases in which two or more antecedents appear to be playing a similar role tend to fumble our pretheoretical intuition about cause and propose a sequence of counterfactual tests based on actual examples from causal historiography.
Decentralized dynamic safety control for battery energy storage system in autonomous DC microgrids
Authors: Fu Xia , Cui Chenggang , Wang Xiaoyu , Cao Zhongkun , Niu Xitong , Liang Kun , Zhang Chuanlin
Published: February 2025

This paper is aiming to address a decentralized dynamic safety control issue for battery energy storage system in DC microgrids. A novel dynamic control barrier function (DCBF) based on nonlinear disturbance observers is devised in the decentralized converter control to restrain the current value while ensuring DC bus voltage regulation. First, a DCBF dependent on load variation is built in order to restrain the current value of each energy storage unit triggered by sudden load changes. Second, a decentralized composite control law, incorporating the DCBF via quadratic program (QP), achieves the objective of current constraint while ensuring the large-signal stability of the DC microgrids. The efficacy of the proposed method has been validated through both simulations and experimental comparison tests.
Spousal Caregiving Types and Cognitive Trajectories Among Middle-Aged and Older Adults in China
Authors: Guo Yu , Zhang Zhenmei , Jiang Quanbao
Published: February 2025

Objectives: This study investigates the longitudinal association between spousal caregiving types and cognitive trajectories among middle-aged and older Chinese adults, with a focus on gender differences. Method: Data from the China Health and Retirement Longitudinal Study (CHARLS) (2011–2018) were analyzed, covering 4568 couples aged 45 and above. Caregiving types were Activities of Daily Living (ADLs) caregiving, Instrumental Activities of Daily Living (IADLs) caregiving, and both ADLs/IADLs caregiving. Cognitive function was assessed using tests of memory, orientation, numeric ability, and visuospatial ability. Latent growth curve modeling was used to examine associations between caregiving types and cognitive trajectories. Results: Spouses who only provided IADLs caregiving had slower cognitive decline compared to those who did not provide caregiving, regardless of gender. However, those who provided ADLs caregiving had faster cognitive decline compared to non-caregivers, especially in women. Discussion: These findings highlight the importance of caregiving types as well as the gendered effects of caregiving on cognitive trajectories.
Role of Corporate Social Responsibility in the Financial Sustainability of Sports Organizations
Authors: Chen Tzu-Chia
Published: February 2025

Corporate social responsibility (CSR) has gradually more important for sports organizations as they seek to improve their financial sustainability. A growing number of sports organizations are recognizing the strategic value and potential benefits of CSR and are implementing CSR initiatives into their operations. The study explores the impact of CSR on the financial sustainability of sports organizations. Through a complete assessment of the literature and analysis of relevant data, the study examines the impact of various CSR initiatives, such as sponsorship and funding, charities through partnerships, organizational commitment, and stakeholder satisfaction on the financial sustainability of sports organizations. Furthermore, the study analyzes the impact of external factors, such as global economic recession and proper fund utilization on the financial sustainability of sports organizations. The findings reveal that proper implementation of CSR initiatives can positively impact the financial sustainability of sports organizations. CSR partnerships with charitable organizations can provide an effective way for sports organizations to improve their social profile, while also helping to generate revenue and financial stability. The study also highlights the significance of stakeholder satisfaction and organizational commitment towards CSR activities in improving financial sustainability. The outcome of this study underscores the importance of CSR in the financial sustainability of sports organizations and provides insights into how sports organizations can leverage CSR to improve their long-term financial sustainability while also benefiting society at large. The findings show that factors, such as sponsorship and funding, proper fund utilization, global economic recession, charities through CSR partnerships, organizational commitment to CSR activities, and stakeholder satisfaction have a significant impact on the financial improvement of sports organizations. The factor “improving social profile” doesn’t have an impact on the financial improvement of sports organizations.
Effect of caffeine supplementation on physical performance in a 5 km cycling time trial of healthy young adult women in different phases of the menstrual cycle: A parallel, randomized, double-blind, placebo-controlled clinical trial
Authors: Mendes Gabriela Lima , Oliveira Higor Alexandre , Santana dos Reis Anderson , Nakamoto Fernanda Patti , Staibano Aline , Alvares Leonardo Azevedo , Simões Ferreira Raphael Einsfeld , Thomatieli-Santos Ronaldo Vagner , Quaresma Marcus V. L. dos Santos
Published: February 2025

Background

Although caffeine is the most studied ergogenic aid, few studies have been conducted to evaluate the effect of caffeine supplementation among women in different phases of the menstrual cycle (MC).

Aim

To verify the effect of caffeine supplementation and the MC phase on the performance of a 5 km cycling time trial of female exercise practitioners (FEP).

Methods

This was a parallel, double-blind, randomized, placebo-controlled clinical trial with a sample of women aged 18–35 years, all with regular MC. The caffeine (CAFG) and placebo (PLAG) groups performed the exercise test during the late follicular phase and mid-luteal phase. These time points were individually assessed according to each woman's MC. On the test day, they were instructed to intake a standardized meal. Subsequently, 30 min following the meal, volunteers consumed caffeine (6 mg·kg−1) or placebo. One hour following caffeine intake, the exercise protocol started. The participants were instructed to perform an all-out 5-km cycling time trial.

Results

Twenty-one women with a mean age of 26.6 years (PLAG, n = 10; 26.7 y; CAFG, n = 11; 26.5 y) were evaluated. The mean test duration was approximately 10-min, with no effect of the MC phase ( F = 0.410; p = 0.532), caffeine supplementation ( F = 2.23; p = 0.156), or interaction ( F = 0.298; p = 0.593). Likewise, we did not verify the effect of the MC phase ( F = 0.249; p = 0.625), caffeine supplementation ( F = 2.35; p = 0.146), or interaction ( F = 0.585; p = 0.456) on the mean power.

Conclusion

Neither caffeine supplementation nor the different MC phases had an impact on the 5-km cycling TT performance of FEP.
The Heart of the Matter: Exploring a Veteran's Wish for Pacemaker Deactivation
Authors: Meyerson Jordana L. , Kowaleski Jeffrey M. , McClelland McKenzie R.
Published: February 2025

Individuals living with serious illness might request deactivation of a cardiac implantable electronic device for a variety of reasons. Discontinuation of implantable cardiac defibrillators and pacemakers are considered to be ethically sound procedures. However, healthcare professional comfort with discontinuation of different types of devices might vary. In this case we describe a veteran's request for pacemaker deactivation and our interdisciplinary team's response to this request, including evaluation of total suffering, ethical considerations, and mood symptoms at end-of-life.
Suicide Ideation Among Justice-Involved Youth: Trauma History, Mental Disorder, and Experiences in Residential Facilities
Authors: Liu Lin
Published: February 2025

In extant suicide studies on youth in juvenile justice residential facilities, limited research attention has been dedicated to the joint effects of existing suicidality imported by an individual into a facility and the experiences in the facility. The current study conceptualized two camps of determinants of suicide among youth in juvenile justice residential facilities: risks individuals imported into a facility as well as what occurred in a facility. Using state-wide data of justice-involved youth above 8 years, the present study examined the joint effects of these predictors. Results suggested that net of the effects of traumatic childhood experiences and histories of mental disorders, the parental support youth received as well as their participation in prosocial activities in a facility neutralized the risk of suicide ideation. Furthermore, the sets of predictors of suicide ideation were not identical in different types of facilities. Implications for improving screening tools and intervention programs were discussed.