bluuebunny/crossref_metadata_2025 huggingface dataset:
Picroside II prevents HSC activation and liver fibrosis in Mdr2-/- mice by polarizing M1 macrophages and balancing immune responses
Authors: Jia Kexin , Ma Zhi , Zhang Yinhao , Wu Jianzhi , Xue Xiaoyong , Liu Runping , Qu Jiaorong , Li Fanghong , Li Xiaojiaoyang
Published: April 2023

Background and Purpose:  Macrophages are central immune characters in
hepatic fibrosis by reconstructing the fibrotic immune microenvironment.
Picroside II (PIC II) has exerted a therapeutic potential on liver
injury. However, the mechanisms by which macrophage initiates immune
cascades and further contributes to liver fibrosis and whether this
process can be influenced by PIC II remains unclear. Experimental
Approach: In this research, the RNA sequencing of multidrug-resistance
protein 2 knockout (Mdr2-/-) mice was applied. Then aHSCs were incubated
with the medium from M1 macrophages and NK cells, with the extra
formation of neutrophils extracellular traps (NETs) being tested. In
addition, we intraperitoneal injected PIC II and then intravenously
injected the clodronate liposome to evaluate the therapeutic effect of
PIC II and macrophage deletion in Mdr2-/- mice. Key Results: We observed
the increase of CXCL16+ M1 macrophages in Mdr2-/- liver, accompanied by
the recruitment of CXCR6+ NK cells and NETs formation. PIC II promoted
the CXCL16+ macrophage recruited NK cells via CXCL16/CXCR6 axis, which
subsequently affecting the JAK1/STAT1 signaling in aHSCs. And fibrotic
liver was relieved to some extent when PIC II combined with macrophage
depletion. Conclusion and Implications: Mechanistically, PIC II
activated M1 macrophage to recruit NK cells via CXCL16-CXCR6 axis and
subsequently regulated the JAK1/STAT1 signaling to restrain aHSCs. PIC
II also alleviated fibrosis by attenuating the formation of NETs.
Notably, these PIC II-associated hepatoprotective effects were largely
reversed by macrophage depletion in Mdr2-/- mice. Collectively, our
research suggests that PIC II is potential for halting the liver
fibrosis.
Methods for the relative quantitation of the human plasma lipidome by liquid chromatography coupled with mass spectrometry using minimal sample manipulation
Authors: Taylor Diane , Sousa Bebiana C. , West Greg , Huipeng Aveline Neo , Lopez-Clavijo Andrea F.
Published: April 2023

Extraction protocols and liquid chromatography coupled with mass
spectrometry (LC-MS) and tandem mass spectrometry methods (LC-MS/MS) for
the measurement of five lipid categories, namely; glycerophospholipids,
glycerolipids, sphingolipids, sterol lipids and fatty acyls in human
plasma are described here. Step-by-step instructions are provided for
the liquid/liquid extraction methods, including solution preparation and
the non-endogenous lipid internal standards used. All instrumental
conditions, chromatography columns and solutions required for the LC-MS
and LC-MS/MS methods are also detailed.
Environmental assessment of Al-Hillah River pollution at Babil Governorate (Iraq)
Authors: Maaroof Bashar , Omran Makki , Al-Qaim Fouad , Salman Jasim , Hussain Bader , Abdellatif Mawada , Carnacina Iacopo , Al-Hasani Ban , Jawad Muhammad , Hussein Wiam
Published: April 2023

In this study, the environmental characteristics of Al-Hillah River were
studied using geoinformatics applications, which is one of the geospatial
techniques (GST). Applying this methodology, a geographic information system
was developed, and it was supplied with laboratory data for the physical and
chemical properties of 16 parameters for 2021. These data were linked to
their spatial locations, using radar imagery of the Digital Elevation Model
(Shuttle Radar Topography Mission), and Landsat ETM+7 satellite image. The
results indicated that Al-Hillah River was affected by the liquid discharges
of factories, cities, and farms spread on its sides, especially in the
cities of Sadat Al-Hindiya, Al-Hillah, and Al-Hashimiyah. The seasonal
changes in the climate affected some characteristics, including water
temperature, pH, turbidity, total dissolved solids, and total hardness. The
study showed that the concentration of sulfate (SO4) has risen above the
permissible limits for the waters of Iraqi rivers. There are relatively high
hardness and alkalinity values, but they were within the permissible limits.
The study also showed that most of the results of environmental parameters
that were used in the laboratory, were within the permissible limits of
Iraqi water, except for sulfates. The justification for conducting this
study is to help government agencies and decisionmakers to adopt a correct
vision for development projects that serve Babil Governorate. Also, it is
the first time that the environmental characteristics of Al-Hillah River are
studied using geoinformatics applications.
Catching-up regional strategy as a tool to reduce spatial inequality
Authors: Chistyakova Natalia , Mikhalchuk Alexander , Bocharova Yulia , Akerman Ekaterina , Tatarnikova Valeria
Published: April 2023

The article is devoted to the problem of spatial inequality of regions caused
by centripetal or centrifugal forces because of agglomeration effects and
interaction costs. It corresponds with the main idea of new economic
geography. A differentiated approach to regional development strategizing is
proposed in the study as a tool for reducing the level of spatial imbalance.
Herein the use of technological arbitrage (catching-up) strategy is proposed
for peripheral regions by strengthening interregional interaction. In the
paper, two hypotheses are investigated: (1) The economic growth of
territories, caused by industry diversification, positive externalities from
Research and Development, the quality of human capital, which are typical of
the ?center? type of regions and (2) The formation of a unified
macroeconomic space is possible due to strategies of technological arbitrage
(catchingup strategy) for peripheral regions. Its implementation is possible
through innovation, industrial-technological, and trade-technological
complementarity development of peripheral regions with the central regions.
The research methods are: panel regression with fixed effects, Data
Envelopment Analysis method, and Malmquist Productivity Index, paired
interregional complementarity indices. The study focuses on 10 regions of
Siberian Federal District in the Russia, which differ in scale, structure,
and level of innovative economic development. The study results confirm the
possibility of reducing the level of spatial inequality using catching-up
strategies and innovation complementarity of the regions. These strategies
proved only for technical efficiency leading regions with high index of
complementarity. In regions with a low complementarity index and different
industry profile, large-scale interregional cooperation has not been
confirmed.
The impact of volumetric modulated arc radiotherapy on clinical outcomes of patients with gynecological malignancies
Authors: Rakin Milijana , Anicic Natasa , Ivanov Olivera , Jaric Sanja , Novakovic Nemanja , Korpivica Ivan
Published: April 2023

Introduction. In locally advanced cancers of the cervix, endometrium and
vulva, radiotherapy is the primary treatment modality. In recent years, new
modern techniques of external radiation have been developed in radiation
oncology, with the goal of dose escalation to the target volume, while
sparing healthy tissues. The aim of this study is to determine the impact of
volumetric modulated arc therapy on clinical outcomes of patients with
gynecological malignancies. Material and Methods. Data were retrospectively
collected from 60 patients treated for International Federation of
Gynecology and Obstetrics stage I - III cervical, endometrial and vulvar
cancers, using definitive (n = 35) or adjuvant (n = 25) radiotherapy/
chemoradiotherapy. Thirty patients underwent three-dimensional conformal
radiation therapy (definitive in 22 and adjuvant in 8) and the other 30
patients were treated with volumetric modulated arc therapy (definitive in
13 and adjuvant in 17). The following clinical outcome parameters were
compared between the two groups: complete clinical response, disease free
survival, progression free survival, and 4-year overall survival. Results.
Progression free survival of patients treated with definitive radiotherapy/
chemoradiotherapy using volumetric modulated arc therapy was 17.2 months,
while in the group treated with three-dimensional conformal radiation
therapy it was 7.9 months (p = 0.300). Four-year overall survival in
patients who were treated with definitive radiotherapy/ chemoradiotherapy
using three-dimensional conformal radiation therapy was 50%, and 61.5% in
the group treated with definitive volumetric modulated arc therapy (p =
0.200), while in patients treated using adjuvant
radiotherapy/chemoradiotherapy it was 75% vs. 88.2%, respectively (p =
0.400). Conclusion. Although without statistical significance, volumetric
modulated arc therapy showed better results with respect to progression free
survival and 4-year overall survival in previously unoperated patients who
underwent definitive radiotherapy/chemoradiotherapy.
Erratum
Authors: Editorial E
Published: April 2023

In the double issue of the journal Medical Review 3-4/2022, an inadvertent
error occurred when entering the DOI number for the paper entitled
Congenital Pulmonary Airway Malformation In Adults - Case Series by Ivan
Ergelasev and associates published on pages 128-131. The published DOI
number is https://doi.org/10.2298/MPNS2204133P. The correct DOI number for
this paper is https://doi.org/10.2298/MPNS2204128E. On this occasion, we
sincerely apologize to the authors for an unintentional mistake, and a
correction will be made on the websites of DOI Serbia and the Society of
Physicians of Vojvodina.

 Link to the corrected article 10.2298/MPNS2204128E
Bone marrow metastasis from testicular seminoma in a patient with concomitant follicular non-Hodgkin lymphoma: A case report
Authors: Ilic-Sabo Jelena , Ivic Stefan , Milenkovic Ana , Trkulja Milica , Tovilovic Vanja , Golijan Borislav
Published: April 2023

Introduction. Seminomas are the most common testicular tumors. Initial
therapy includes orchiectomy with resection of local lymph nodes, followed
by adjuvant radiotherapy. Testicular tumors usually metastasize to
retroperitoneal and mediastinal lymph nodes, lungs, liver, spleen,
gastrointestinal tract, and adrenal glands. Bone metastases from testicular
tumors are very rare, while seminoma metastasis to the bone marrow is a
curiosity, without any references in the scientific literature. Case Report.
A 66-year-old patient, previously treated for follicular non-Hodgkin
lymphoma, was admitted due to complaints of malaise, abdominal and back
pain, and hepatosplenomegaly. After examination and radiologically verified
enlarged retroperitoneal lymph nodes, the patient was referred to a
hematologist. Based on the patient?s medical history, a relapse of lymphoma
was suspected, and bone marrow biopsy was performed. The hematoxylin-eosin
staining of the biopsy sample showed diffuse large cell infiltrates with
bright cytoplasm, polygonal nuclei and prominent nucleoli. By
immunohistochemical staining, the cells showed positivity for cluster of
differentiation 10, cluster of differentiation 117, octamer binding
transcription factor 3/4, placental alkaline phosphatase, and cytokeratin
8/18, after which the diagnosis of seminoma metastasis to the bone marrow
was made. Shortly after the histopathological diagnosis was made, the
patient died. Conclusion. A seminoma is a testicular tumor with a favorable
prognosis. Due to suppression of hematopoiesis, bone marrow metastases
generally lead to the worst prognosis. The outcome of our patient highlights
the importance of timely diagnosis and therapy, which would increase the
chances of survival.
First reported cases of hepatitis A virus and human immunodeficiency virus coinfection in Vojvodina, Serbia: A case report
Authors: Drljaca Maja , Ruzic Maja , Maric Daniela , Rajic Natalija , Djurica Jelena , Ilic Svetlana
Published: April 2023

Introduction. Hepatitis A virus is the most common cause of acute viral
hepatitis, and in people over 25 years of age the disease may have different
degrees of severity. Even though hepatitis A virus infection was long
believed to be transmitted strictly by fecal-oral route, now this virus is
classified among sexually transmitted diseases. Homosexual population,
especially those positive for human immunodeficiency virus, is at the
greatest risk of hepatitis A virus infection. Case 1. A twenty-six-year-old
male homosexual was admitted with clinical and laboratory findings of acute
hepatitis. The patient tested positive for enzyme-linked immunosorbent assay
immunoglobulin M antibodies to hepatitis A virus and human immunodeficiency
virus antibodies, and later on human immunodeficiency virus infection was
confirmed by polymerase chain reaction test. After the discharge, the
antiretroviral therapy was initiated. Case 2. A twenty-seven-year-old male
homosexual was transferred to our clinic from the Regional Hospital, where
he was hospitalized due to acute hepatitis A virus infection, after a
positive serological test for anti-human immunodeficiency virus antibodies.
Human immunodeficiency virus infection was confirmed by polymerase chain
reaction test, and upon discharge, antiretroviral therapy was initiated.
Conclusion. In order to take the most effective preventive measures, it is
very important to identify individuals and groups at high risk of
coinfection with human immunodeficiency virus and hepatitis A virus. Timely
vaccination against hepatitis A virus among people living with human
immunodeficiency virus is recommended and therefore it is necessary to
design effective strategies for education of groups at risk.
Online detection and source tracking of common incense burning
Authors: Yin Yijun , Wan Enlai , Ye Yanpeng , Yan Yihui , Cai Yuyao , Cai Jinzhu , Liu Yuzhu
Published: April 2023

The burning of incense produces toxic and harmful gases and particulate matters, posing a tremendous threat to both human health and the atmospheric environment. As a consequence, online in situ detection, classification, and traceability of burnt incense are of vital importance. In this paper, taking ambergris, musk, and Tibetan incense as examples, laser-induced breakdown spectroscopy (LIBS) is applied to the online detection of smoke and ash from the burning of three common types of incenses. It is found that metallic elements such as K, Mg, and Ca are present in the smoke. In contrast, more complex metallic elements, such as Fe, Al, Mn, Sr, etc., are present in the incense ash. By comparing the smoke and ash spectra of three different incenses, the feature spectra with large differences are selected, and the data are dimensionality reduced using the principal component analysis. Combined with error back propagation training artificial neural networks, the classification and traceability models of the smoke and ash from different incenses are performed, and the final recognition accuracies are 93.24% and 96.33%, respectively. All the results indicate that the combination of LIBS and machine learning has good application prospects for detecting and online tracing different incense smoke and ash and is also beneficial for human health and the natural environment.
Types and Distribution of Fetal Congenital Anomaly and their Maternal Characteristics in High Risk Pregnancy Unit of Dhaka Medical College Hospital, Bangladesh
Authors: MT Sultana
Published: April 2023

Introduction: Congenital anomaly is one of the important causes of perinatal mortality and morbidity. Proper information regarding its prevalence, distribution as well as risk factors can help policy makers to take appropriate steps for prevention. Materials and Methods: A hospital record based observational study was done in Obstetric department of Dhaka Medical College Hospital, Bangladesh during the year of 2020. The aim of the study is to evaluate the pattern of anomaly found in admitted patients in Maternal Fetal Medicine unit, along with the maternal demographic profile and associated diseases. After taking ethical clearance and permission from department detailed information was collected and analysis was done. Results: In the year 2020 total 6012 delivery was occurred and 4.42% of them were anomalous baby. The maternal characteristics showed that mean maternal age was 26.24(±5.25) years. 20.7% of mother had previous history of abortion, 7.7% has previous perinatal death and 3.3% have previous anomalous baby. 5.49% mother had Diabetic disorders and 4.39% had congenital heart disease. Associated poly hydramnios was found in 17.7% and oligohydramnios was found in 12.1% of cases. The distribution pattern of anomalies according to system involved showed that 41.7% was Central Nervous System anomaly, 8.7% was Renal anomaly, 6.5% was Musculoskeletal anomaly, 4.4% was Gastrointestinal anomaly,6.6% had body wall defect , 10.9 % was Non immune Hydrops, 3.3% was Syndromic baby and 13.1% had multiple congenital anomaly. Conclusion: It is a tertiary hospital based study. So it may not reflect the actual picture of population. So community based study is needed for further advancement.
Factors Influencing Attendance and Academic Performance Among Student-Athletes in the Obuasi Municipality, Ghana
Authors: Yawson Joseph Anthony , Apaak Daniel , Baidoo Stephen
Published: April 2023

The present research examined variables affecting senior high school student-athlete attendance and academic performance in Obuasi Municipality of Ashanti Region. For the study, a descriptive survey design was used. 203 student-athletes who compete in games and track and field events at two public senior high schools made up the sample size. All of the student-athletes in form three and form two were surveyed using a census method. To collect information from the study’s participants, a questionnaire was used. According to the results of the multiple regression analysis, personal characteristics had the highest correlation with student-athlete academic performance (r=0.28), followed by coaching factors (r=0.27), and school factors (r=0.22). The recent investigation also showed that no factor predicted attendance of student-athletes (F (1,201)=2.005, p=0.158, R2=0.359. It is recommended that authorities in senior high schools in the Obuasi municipality should ensure that Student-athletes are not affected by influences from school, other teachers, and coaches as it can impact their academic performance. Student-athletes should be encouraged and motivated to learn as their own activities can affect their academic performance.
The Mediating Role of Psychosocial Working Conditions on Physical Work Environment and Workplace Stress in Higher Education: Empirical Evidence from Selected HEIs in Southern Philippines
Authors: Becaro Jishanis M. G. , Beliganio Allan V. , Maganding Liza M. A. , Dingding Rosemarie E.
Published: April 2023

Many factors, including workload, student-related issues, research and job development, interpersonal relationships, and administrative-related issues, have been linked to workplace stress, with higher academic institutions (HEIs) seeing the most of it. While several studies have looked into various aspects of work stress in HEIs, very few studies have investigated how psychosocial factors mediate the effect of the physical environment to work stress. Thus, this study is conducted to empirically test how psychosocial working conditions significantly mediate the influence of Physical work Environment on workplace stress in Higher Education Institutions in the Philippines. Involving 265 teaching faculty in selected HEIs in Southern Philippines, the study utilized structural equation modeling to analyze the interest constructs. The results showed that Physical Work Environment significantly influences Psychosocial Work Environment while Psychosocial Work Environment significantly influences work stress). In contrast, the path from Physical Work Environment to work stress was not statistically significant. Thus, Psychosocial Work Environment fully mediates the influence of the Physical Work Environment on an individual’s work stress level. Put differently, physical work environment could only result in work stress if Psychosocial Work Environment mediates it.
The Phenological Characterization of Calotropis procera (Ait) and its Potential for Domestication for Wool Production in Drylands
Authors: Mutiso Festus M. , Kimiti Jacinta M. , Muchugi Alice N. , Kimatu Josphert N.
Published: April 2023

Nowadays, attention is being paid to exploration of possibilities of exploiting new and under-utilized plant resources with the aim of meeting the growing societal needs. Calotropis procera is one among the many under-utilized species despite its many economic and ecological uses. This study was done to characterize the phenology of the species and determine its potential for domestication for wool production. Phenological data was used to generate charts that depicted the flowering and fruiting phenophases for three provenances for four seasons. The data was subjected to Test of Homogeneity of Variances to isolate significant differences in study parameters. Spearman rank pair-wise correlations between wet seasons and flowering were done. Flowering intensity in different months of the year was significantly different (p<0.05) with clear-cut flowering phenophases. Flowering and fruiting durations and active phases were significantly longer and high (p<0.001) during the wet seasons and spearman rank correlations between wet seasons and flowering ranged from 0.89 to 0.96 and were highly significant (rs, pair-wise correlations, p<0.0001). A very low flower to fruit ratio was recorded. The study concluded that C. procera can do well as a plantation crop and has a high potential for production of wool. The strongest impediment to flowering and fruiting was periodic attack by Aphis nerii. It is recommended that propagation seeds for C. procera should be sourced from the local provenances to reduce the effects of seed source transfer distance.
Effect of nalbuphine or ketamine on xylazine requirements in standing sedated horses
Authors:   Department of Surgery, Anesthesiology and Radiology. Faculty of Veterinary Medicine, University of Sadat city, Egypt, Sharshar Ahmed , Hammad Amal , Gadallah Shaaban , Thabet Nahed , Misk Tarek
Published: April 2023

Despite the pivotal role of α2 -agonists for standing sedation in horses, these drugs possess several dose-dependent side effects. Therefore, this study aimed to determine the effect of nalbuphine or ketamine on xylazine requirements necessary to provide constantly moderate sedation in horses. Five healthy adult horses were subjected to three randomized treatments at one-week intervals as follows: xylazine (XYL) (xylazine: 0.55 mg/kg, IV; saline: bolus & CRI); xylazine/nalbuphine (XYL/NAL) (xylazine: 0.55 mg/kg, IV; nalbuphine: 0.3 mg/kg, IV & 0.23 mg/kg/hour CRI) and xylazine/ketamine (XYL/KET) (xylazine: 0.55 mg/kg, IV; ketamine: 0.1 mg/kg, IV & 0.5 mg/kg/hour CRI). On all occasions, moderate sedation was maintained for 120 minutes by administering additional xylazine boluses (0.14 mg/kg, IV) whenever lower sedation was demonstrated. All treatments were assessed in terms of the degree of sedation, the time of administering the first additional xylazine bolus, and xylazine requirements (presented as mg/kg/hour) for maintaining moderate sedation for 120 minutes. The degree of ataxia and adverse events were also monitored. Sedation scores were significantly higher than the baseline for all treatments over 120 minutes. A longer time before the first additional xylazine bolus and lower xylazine requirements (lower calculated infusion rates) for maintaining moderate sedation were evident following the XYL/NAL and XYL/KET treatments compared to the XYL treatment. All treatments were associated with an acceptable degree of ataxia and limited behavioral effects. In conclusion, both nalbuphine and ketamine were efficient in reducing xylazine requirements for constant sedation in horses. Further study is required for comprehensive testing of all studied combinations to elucidate the potential advantages of the demonstrated xylazine sparing effect.
Financial results of the organization’s activities as an object of accounting and their regulatory regulation
Authors: Moskalenko N. V. , Smagina M. N. , Selivanova P. S.
Published: April 2023

The income statement is an accounting form that reflects the financial results of the organization’s activities for the reporting period and contains data on revenue and expenses from ordinary activities, as well as other income and expenses. Accounting for financial results is necessary to assess the economic life of the enterprise. Information about the company’s financial results is important both for internal analysis and for interaction with potential partners. With the help of these indicators, it is possible to analyze the efficiency of the enterprise as a whole and develop a further strategy of behavior in the market, therefore, the correct accounting of financial results is very important from the point of view of the economy. The subject of the research is the report on financial results. The purpose of the report on financial results is formulated in the article, its characteristics are given, and the article also substantiates the necessity and importance of analyzing the financial results of the organization. So, in the conditions of escalating economic and political tension in the modern world, the procedure for the formation, analysis and application of financial results by organizations becomes even more relevant. For effective analysis, it is important to organize timely and accurate accounting of the financial results of the organization. Without a competent analysis of the results of the financial activity of the enterprise and the identification of factors affecting this activity, it is impossible to increase the level of profit and profitability.
Comfortable urban environment as a basis for social adaptation of people with disabilities
Authors: Khabarov V. I. , Bruev S. V.
Published: April 2023

An urban environment with comfort zones is an important condition of modern human life, in particular, it is directly related to people who have limited mobility. The lack of necessary infrastructure makes it impossible for people with disabilities to solve everyday problems and issues.

The term «accessible» or «barrier–free» environment is mentioned in many legislative acts, and has different interpretations in different sources. It should be noted that the importance of this problem has been gaining momentum in recent years, the problem of the quality and accessibility of the urban environment for people with disabilities in everyday life is beginning to come to the fore.

State authorities are creating the necessary conditions for people with disabilities, which are aimed at developing services, helping to overcome barriers that prevent people with disabilities from taking full part in society. People are rethinking the quality problem anew and accessibility of the urban environment for the disabled, develop special programs to improve the quality of the urban environment.

This article will help to analyze the main components of a comfortable urban environment for people with disabilities, there is a set of measures, problems, solutions that help to form a comfortable urban environment for various categories of the population.
Eighteenth Century Birmingham Bell Ringers: A Genealogical Perspective
Authors: Bowsher Elizabeth
Published: April 2023

By the end of the eighteenth-century the St Martin’s Youths of Birmingham was one of the leading bell ringing societies outside London, as it remains to this day. The handwritten peal books in the Archive of the St Martin’s Guild, its modern successor, provide a record of the peals rung by the society from 1755, but little was known of the eighteenth-century ringers themselves beyond a few anecdotes contained in the oral history for a later period. Genealogical records and techniques allowed a fuller understanding of the lives of the ringers to be disclosed, informing a new narrative of the history of ringing in Birmingham and the place of the ringers in Birmingham at a significant period in the town’s history. The article shows how niche sources can be combined with genealogical and other sources to provide insights into the lives of members of an eighteenth-century society.
Peran Ganda Jurnalis dan Penyimpangan Kode Etik Jurnalistik
Authors: Wicaksono Agung Priyo
Published: April 2023

ABSTRAKPenyebab Peran Ganda Jurnalis Dan Penyimpangan Kode Etik Jurnalistik. Pesatnya kemajuan teknologi dan komunikasi berpengaruh besar bagi kematian media konvensional. Keadaan ini memaksa media untuk membebani jurnalis dengan peran ganda agar dapat menghidupi media. Penelitian ini bertujuan mengetahui penyebab peran ganda di kalangan jurnalis. Penelitian kualitatif dilakukan dengan pendekatan fenomenologi. Data dalam penelitian diperoleh melalui Focus Group Discussion dan wawancara mendalam dengan tujuh orang jurnalis dari berbagai media di Yogyakarta. Hasil penelitian menunjukkan tiga poin penting. Pertama, peran ganda terjadi karena persaingan media yang begitu ketat. Persaingan media membuat media konvensional kehilangan kue iklan sehingga memaksa perusahaan untuk memberikan peran ganda kepada jurnalis. Kedua, peran ganda terjadi karena upah rendah yang diperoleh jurnalis. Keadaan ini membuat jurnalis terpaksa menjalankan praktik peran ganda guna mendapatkan upah yang sesuai. Ketiga, peran ganda terjadi karena pola rekrutmen jurnalis yang berorientasi pada pasar bukan pada kompetensi jurnalis. Dual Role of Journalists and Violation of Journalism Ethics. The rapid advances in technology and communication have had a major effect on the death of conventional media. This situation forces the media to burden the dual role for journalists in order to support the media. This study aims to find out the causes of dual roles among journalists. This qualitative research was conducted using a phenomenological approach. The data in this study were obtained through in-depth interviews and Focus Group Discussion with seven journalists from various media in Yogyakarta. The research results showed three important points. First, the dual role occurs because the media competition is so intense. Media competition makes conventional media lose their hot cakes of advertising, forcing companies to give dual roles to journalists. Second, the dual role occurs because of the low wages earned by journalists. This situation forces journalists to practice multiple roles in order to get the appropriate wages. Third, the dual role occurs due to the journalist recruitment pattern which is market oriented, not journalist competence. The results of the research show that the tendency to deviate from the journalism ethics is due to the coercion of media companies for journalists to earn income by becoming advertisers. Intervention by media companies is not justified when journalists perform their professional duties. Similarly, low wages make journalists try to earn additional income by becoming advertisement seekers, which is not in line with the journalist's main duties. In addition, the recruitment of journalists from the start does not focus on professional competence but rather on journalists who are willing to become advertisement seekers, not looking for information.
Arthibition: Designing Augmented Reality for Art Exhibition
Authors: Dewangga Kusuma , Widhiyanti Kathryn , Nastiti Putri , Oktian Yustus Eko
Published: April 2023

ABSTRACTThe Covid-19 pandemic, which occurred in the past 3 years, has forced art activists to reduce activities that involve many people. Meanwhile, art activities that gather many people are still needed as a means of publishing artworks from art activists. Augmented Reality (AR) technology has been widely applied to art exhibitions. To be able to take advantage of this technology, users must come to the exhibition site and scan an object at the exhibition site, resulting in a buildup of visitors at the exhibition site. For this reason, it is necessary to build an application that can be used to enjoy content from the exhibition without having to go to the exhibition location. This study aims to design an application that can be used by the audience to be able to enjoy the content of the art exhibition without having to go to the exhibition site. The use of AR Technology is applied as a tool to ostensibly bring artwork to the location of the application user, so that it can be enjoyed directly. The design of the ARt Exhibition application is expected to be a solution for art activists and connoisseurs to be able to enjoy art exhibitions anywhere personally so that the spread of the Covid-19 virus can be minimized. ARthibition: Mendesain Pameran Seni Rupa dengan Augmented Reality. Pandemi Covid-19 yang terjadi dalam tiga tahun terakhir memaksa para pegiat seni mengurangi aktivitas yang melibatkan banyak orang. Sementara itu, kegiatan seni yang menghimpun banyak orang masih dibutuhkan sebagai sarana penerbitan karya seni dari para pegiat seni. Teknologi Augmented Reality (AR) telah banyak diterapkan dalam pameran seni rupa. Untuk dapat memanfaatkan teknologi ini, pengguna harus datang ke lokasi pameran dan memindai objek di lokasi pameran sehingga terjadi penumpukan pengunjung di lokasi pameran. Untuk itu, perlu dibangun sebuah aplikasi yang dapat digunakan untuk menikmati konten dari pameran tanpa harus pergi ke lokasi pameran. Penelitian ini bertujuan untuk merancang sebuah aplikasi yang dapat digunakan oleh penonton untuk dapat menikmati isi dari pameran seni rupa tanpa harus mendatangi lokasi pameran. Penggunaan teknologi AR diterapkan sebagai alat untuk membawa karya seni ke lokasi pengguna aplikasi sehingga dapat dinikmati secara langsung. Perancangan aplikasi pameran seni rupa ini diharapkan dapat menjadi solusi bagi para pegiat dan penikmat seni rupa untuk dapat menikmati pameran seni rupa dimanapun secara personal sehingga penyebaran virus Covid-19 dapat diminimalkan
Application of Trichoderma sp. and PGPR for preventing downy mildew incidence on sweet corn
Authors: Purwanti Eny Wahyuning , Wahyudi Diki , Hamyana
Published: April 2023

Downy mildew is a disease caused by the fungus Peronosclerospora maydis. Application of biological agents to control downy mildew is a kind of environmentally friendly control method, that widely promoted recently. Trichoderma sp. and plant growth promoter rhizobacteria (PGPR) are root symbionts, which can induce plant resistance against disease infection. This study aimed to determine the effective application of Trichoderma sp. combined with various concentrations of rhizobacteria to control downy mildew. This study used a completely randomized design (CRD) method with 6 treatments and 5 replications. The treatment was the concentration of rhizobacteria consisting of P0 (control) = without treatment, P1= 15 mL L-1. P2 = 30 mL L-1. P3 = 45 mL L-1. P4 = 60 mL L-1 and P5 (positive control) = seed treatment with 5 g kg-1 dimetomorf fungicide. Each rhizobacteria suspension was mixed with Trichoderma sp. solution as much as 15 mL L-1. The parameters observed consisted of plant height (cm), number of leaves, disease incidence (%), and disease severity (%). The results showed that the combination of Trichoderma sp. and rhizobacteria of 60 mL L-1 was able to inhibit the incidence of the disease up to 66.53% and the severity of the disease up to 89.84%.

Keywords: bacteria, concentration, downy mildew, sweet corn, Trichoderma sp.
Yield component evaluation of mutated sugarcane at first and ratooning plantations
Authors: Ariyanto Fimas , Muhammad Ubaidillah  , Sri Hartatik
Published: April 2023

Increasing national sugar production can be done by developing new varieties of sugarcane varieties with high potential yields. To ensure profitability and sustainability, however, the new varieties should be accompanied by data on their ratooning ability. This study aimed to evaluate the stability of the yield component of ratooning sugarcane resulting from mutations. The experiment was arranged using a factorial randomized complete block design with the first factor being four genotypes of sugarcane (G) consisting of three mutant genotypes with codes M3.2, M3.3, M3.4 and one original Bululawang genotype (BL). The second factor was ratooning (K) which consisted of three levels, namely first plant (TP), first ratoon (TK1) and second ratoon (TK2). The combination of treatments was repeated 4 times so that 48 unit combinations were obtained. One unit consisted of 28 cane clumps divided into 4 rows. The results showed that the ratooning factor had a significant impact on the value of the proportion of sucrose produced by the mutant sugar cane genotype. The ratooning ability of mutant genotypes to produce sucrose was recorded above 75%. All genotypes of mutant had superior characters compared to non-mutant based on stalk weight and percentage of sucrose.

Keywords: Bululawang, morphology, mutant, ratoon, sugar
Lung Ultrasound and Caval Indices to Assess Volume Status in Maintenance Hemodialysis Patients
Authors: AL-Saray Mujtaba Z. , Ali Ala
Published: April 2023

Background: Volume overload is common in end stage kidney disease (ESKD) and dialysis patients. Hence, the need for objective tools to detect such volume excess. Point of care ultrasound (POCUS) is a goal-directed, bedside examination to answer such a specific diagnostic question. Methods: One hundred Iraqi adult hemodialysis patients were recruited from February 1 to May 31, 2022. Primary clinical, dialysis data, and prescriptions were recorded. A nephrologist performed a POCUS examination after the last dialysis session of the week. In addition, an ultrasound examination of the chest was performed to detect B-lines and pleural effusion. Caval parameters included inferior vena cava (IVC) diameter and collapsibility index.  Results: The mean age of the study group was 51.48 ± 14.6 years, with 53% males. The mean interdialytic weight gain was 2.74 ± 1.15 Kg. Lower limb edema and pleural effusion were present in 33% and 27%, respectively. Forty-seven percent of patients had >3 B-lines on lung ultrasound with a range of 12. Forty-three percent of patients had an IVC diameter of >2 cm, and 93% had <50% IVC collapsibility. In total, 97% of patients had evidence of excess volume by ultrasound criteria. IVC collapsibility index was the most prevalent sign of excess volume (93%). Patients without lower limb edema and pleural effusion had positive B-lines in 38.8% and 38.3%, an IVC diameter >2 cm in 46.2% and 38.3%, and IVC collapsibility <50% in 89.5% and 95.8% respectively.  Conclusion: Iraqi maintenance hemodialysis patients are volume overloaded, which warrants proper intervention for detection and dialysis management. POCUS is a useful and easily performed technique to assess the volume status.
Virtual Supervision of Third Year Medical Students Using Handheld POCUS Devices and Cloud-based Image Archiving Provides Opportunity for Feedback and Skill Improvement
Authors: Murray Sydney , Trinder Krista , Kolbenson Linden , Katulka Jeremy , Olszynski Paul
Published: April 2023

Background: Feedback on Point of Care Ultrasound (POCUS) skills is essential for skill development. Providing feedback can be difficult in a large province with several distributed medical education sites. Use of handheld POCUS devices and a cloud-based image archiving enables virtual supervision. We evaluated the quality of uploaded images as well as feedback provided to students.  Methods: Volunteer third year students were given access to handheld POCUS devices at various training sites. Students were encouraged to upload educational POCUS scans to their accounts where they would then receive feedback from faculty. Subsequently, images that met inclusion criteria were randomized and reviewed by a blinded expert using a global rating scale. Feedback was also analyzed. Finally, students completed a questionnaire on their technology-enhanced POCUS learning experience.  Results: An independent-sampled t-test comparing mean ratings for initial images submitted prior to any feedback with those submitted after three rounds of feedback showed significant effect on image scores (2.60 vs 3.50, p = .040, d = .93). Feedback included 4 performance domains (indications, image generation, interpretation, and integration). Students found the technology easy to use and felt feedback was tailored to their learning needs.  Conclusions: We observed that virtual feedback provided to medical students through a cloud-based work platform can be effective for enhancing POCUS skills.
Unexpected side effects: A cautionary note on challenges of persistent self-transcendence
Authors: Stephens Elizabeth D. , Friedman Harris L.
Published: April 2023

Self-transcendence is an ambiguous construct without consensual meaning, yet many claim that it relates to, or even causes, beneficial outcomes. Few discuss its potential deleterious side effects, choosing to focus primarily on positive effects. However, anything with sufficient potency to heal may have unintended side effects, especially when it leads beyond a transitory state to becoming an enduring trait, such as when self-transcendence (ST) becomes persistent self-transcendence (PST). With PST, evidence is overviewed here, along with two illustrative case reports, that people can suffer emotional difficulties, motivation changes, loss of self-reflexivity, anhedonia, dissociation, depersonalization, memory problems, and other psychological concerns. This is discussed in terms of the disruption of the sense of self, which ordinarily serves as an integrative center for the person that conveys a sense of agency. Possible neurobiological and sociocultural effects of PST are also discussed, with a focus on its role on narrative memory as the construction of self-concept. Evidence has also been accumulating on problematic side effects of meditation and mindfulness, techniques commonly presented as paths to PST. Given that PST is often presented as a pinnacle of human development and spiritual attainment, seekers of PST, psychologists, and other mental health professionals are urged to become informed about its possible side effects, and view this phenomenon in a more balanced way.
The role of spiritual intelligence and differentiation in predicting marital adjustment of married Iranian students
Authors: Ahmadi Sedighe , Morley Richard H. , Ghalebi Faezeh , Ilanloo Hossein , Nguyen Christine D.
Published: April 2023

The aim of this study was to investigate the role of spiritual intelligence and differentiation in predicting marital adjustment of Iranian students. The participants of this study were 312 married students from Yazd University. The instruments used in this study were the Dyadic Adjustment Scale (DAS) to measure marital adjustment, Differentiation of Self- Inventory, and the Spiritual Intelligence Self-Report Inventory (SISRI). The results of the study demonstrated that spiritual intelligence predicted the marital adjustment of married students (p <0.001). Moreover, spiritual intelligence explains 7% of the variance in the marital adjustment index. Among the predictive components, existential thinking, criticism, and the production of personal meaning demonstrated significant predictive effects on the marital adjustment index in students. The results also showed that differentiation does not predict the students’ marital adjustment, and the subscales of marital solidarity and agreement were positively correlated.
How perception meets hermeneutics: An empirical investigation of tasseography
Authors: Avetisian Elizabeth
Published: April 2023

Tasseography is a divination method to provide insight about the seeker’s past, present, or future life by interpreting patterns in the dregs of a liquid. Although it has been practiced with coffee throughout Europe and Middle East, particularly among women, no known studies exist on the seer’s perceptual process of the ambiguous patterns or how the roles of the seeker and seer, symbols, ritual, and cultural epistemology shape the divinatory hermeneutics. This study focused on the Armenian coffee divination ritual, asking what are the processes and conditions that enable experienced cup readers to obtain divinatory insight in tasseography? Two seekers each produced one cup, photographed and presented virtually to roughly half of a sample of 17 female seers through video-recorded virtual sessions. Seers were interviewed about their experiences of providing reading, data triangulated with their reading data and the two seekers’ reflections on the readings. Thematic analysis revealed that tasseographic interpretation is a psychodynamic embodied process, influenced by the seer’s subjective world and informed by intuitive sources, that engenders empathetic attunement with the seeker. Readings revealed significant thematic convergence and relevance to each seeker’s central query, and reflected the seekers’ life at the time the cup was produced rather than at the time of reading. Interpretation convergence occurred independent of perceptual variation, suggesting that the seers’ semiotic processes involve transpersonal states and sources.
DOAÇÃO E TRANSPLANTE DE ÓRGÃOS E TECIDOS: CONCEPÇÕES DE ADOLESCENTES ESCOLARES PELO USO DO PHOTOVOICE
Authors: Ferreira Diego Raone , Rissi Gabrieli Patrício , Florindo Juliana Cristina de Oliveira Cassiano Silva , De Oliveira Junior Isaias Batista , Higarashi Ieda Harumi
Published: April 2023

Este artigo objetivou compreender as concepções de adolescentes escolares sobre a doação e transplante de órgãos e tecidos. Trata-se de um estudo participativo, descritivo, de natureza qualitativa, desenvolvido com 60 adolescentes escolares do ensino médio da rede pública de ensino do Estado do Paraná. A coleta de dados foi realizada em julho de 2018, com auxílio da técnica Photovoice, e os dados foram analisados na óptica da análise de conteúdo de Bardin. Dos 60 adolescentes, 38 eram meninas (63,3%) e 22 eram meninos (36,7%), sendo a faixa etária dos 16 anos a prevalente (38,3%). Foram selecionadas nove imagens para compor o corpus fotográfico, que deram origem a quatro categorias: com a doação de órgãos existe uma certa união; um gesto de humildade que salva muitas vidas; ter a esperança de que no outro dia alguém pode vir e fazer uma doação e; a real importância de se formar doadores de órgãos. Constatou-se que promover a conscientização para doação e transplante de órgãos e tecidos, principalmente em grupos ativos na sociedade, como os adolescentes escolares, é fundamental para disseminação de informações seguras, construção de novos paradigmas e transformação de concepções e comportamentos.
A system for extracting symptom mentions from texts by means of neural networks
Authors: Власова Наталья Александровна , Момот Седа Рубеновна , Сердюк Юрий Петрович
Published: April 2023

В статье представлена система для извлечения упоминаний симптомов
из медицинских текстов на естественном (русском) языке. Система
осуществляет нахождение симптомов в тексте, их нормализацию (приведение
к стандартной форме) и отождествление — отнесение найденного симптома
к группе однотипных симптомов. Каждый этап обработки реализуется
с помощью отдельной нейронной сети. Состав извлекаемых симптомов
ограничен тремя видами заболеваний — аллергические и пульмонологические
заболевания, а также коронавирусная инфекция (COVID-19).
Представлен и описан аннотированный корпус предложений, использованный
для обучения нейросети нахождению упоминаний симптомов, относящихся
к этим трем заболеваниям. При разметке корпуса был использован простой
XML-подобный язык. Для представления предложений,
непосредственно поступающих на вход нейросети, предложен расширенный
BIO-формат разметки. Для каждого этапа приведены оценки
точности (для первого этапа точность оценивалась при строгом и гибком
тестировании). Описаны подходы и реализация приведения к стандартной
форме и отождествления упоминаний симптомов. Даны сравнения
с аналогичными работами по извлечению симптомов из медицинских текстов
на разных языках, а также показано место данной системы в системах
поддержки принятия клинических решений.