bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of drinking water fluoride on gingivitis and caries: A study in peat and non-peat land: A comparative cross-sectional study
Authors: Rezki Sri , Sunardi Sunardi , Aripin Dudi , Khayan Khayan , Pawarti Pawarti , Noeriman Aisya Rezki
Published: December 2023

Abstract

Aim:

Humans get fluoride from food and water available in their environment. The source of clean water in peatlands comes from rainwater with a low mineral content, especially fluoride. The objective of this study was to investigate the correlation between the fluoride level in drinking water and salivary fluoride levels, as well as their potential impact on dental and oral health conditions.

Materials and Methods:

It is a causal-comparative study with a cross-sectional approach at the Health Polytechnics of Pontianak and Yogyakarta. The population were indigenous people in peat land (Pontianak) and non-peat land (Yogyakarta). The data were pH and mineral content in drinking water, saliva, the number of Streptococcus mutans colonies, dental caries rates, and gingivitis.

Results:

Drinking water fluoride is only significantly correlated with salivary fluoride on non-peat land. If these data are combined, it can be seen that drinking water fluoride is positively correlated (P < 0.05; CI 95%) with pH water, fluoride water, and pH saliva. Increased levels of fluoride in drinking water were negatively correlated with gingivitis, dental caries, and S. mutans.

Conclusion:

Drinking water fluoride is negatively correlated with dental caries and gingivitis in peatland and non-peatland communities, but would be significantly associated with dental caries and gingivitis if both peatland and non-peatland data were analyzed together. This is due to the low content of fluoride in the drinking water of peatland. Therefore, it is necessary to add fluoride gel to the teeth to prevent the development of dental caries.
Comparative evaluation of the antimicrobial activity of NeoPutty MTA and modified NeoPutty MTA: An in vitro study
Authors: Acharya Sonu , Gurunathan Deepa , Sahoo Dipmalla , Singh Bismay , Sahoo Alkananda , Acharya Sheetal
Published: December 2023

Abstract

Aim:

Mineral trioxide aggregate (MTA) is a relatively new versatile dental material. MTA has many advantages as well as disadvantages. To reduce most of the drawbacks of MTA, a premixed bioceramic MTA, NeoPutty MTA, was introduced in 2020. In this study, we assessed the antimicrobial activity of the newer MTA, NeoPutty MTA. We modified NeoPutty MTA and compared both against Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.

Materials and Methods:

Using the agar diffusion method, NeoPutty MTA was tested for antibacterial activity against the above-mentioned microorganisms. A base layer of Petri plates was done using Muller–Hinton agar for S. aureus, E. coli, and P. aeruginosa and brain heart infusion agar for E. faecalis. A total of 32 plates were employed; the plates were divided randomly into four test groups having eight plates each, so microorganisms were tested eight times. Three cavities were made in agar and filled with freshly mixed materials after 24 h. A pour plate seeded the microorganisms. The plates were pre-incubated for 2 h at room temperature and incubated at 37°C for 24 h. An independent observer measured the inhibition zone diameters.

Results:

NeoPutty MTA, when tested alone, did not show much antibacterial activity against E. faecalis, S. aureus, and E. coli but had significant antimicrobial activity against P. aeruginosa when used at different concentrations. Modified NeoPutty (NeoPutty with antibiotics added individually) showed significant antibacterial activity against these microorganisms, as seen by the zone of inhibition of these bacteria.

Conclusion:

Modified NeoPutty with antibiotics has a better antimicrobial effect than NeoPutty MTA.
Cytotoxicity, antimicrobial, anti-inflammatory and antioxidant activity of camellia sinensis and citrus mediated copper oxide nanoparticle—An in vitro study
Authors: Singh Swati , Prasad Arya S , Rajeshkumar Shanmugam
Published: December 2023

Abstract

Aim:

Several applications of copper oxide nanoparticles (CuONPs) have been documented in various fields, including healthcare, dentistry, medication delivery, tissue and cancer imaging, biolabeling, and biosensing. Therefore, this study aimed to synthesize CuONPs using the plant extracts of Camellia Sinesis (CS) and citrus limon (CL). The nanoparticles were then evaluated for their cytotoxicity, antibacterial, anti-inflammatory, and antioxidant activities.

Materials and Methods:

CuONPs were prepared using CS and CL through the green synthesis method. The Zone of Inhibition (ZOI) test was used to assess the antibacterial activity against strains of Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans, and Candida albicans. The albumin denaturation assay was used to assess the substances’ anti-inflammatory activity. The cytotoxicity was determined by conducting the brine shrimp lethality test. Additionally, the antioxidant nature was tested using the 1,1-diphenyl-2-picryl hydrazyl method.

Results:

CuONPs mediated by CS and CL were successfully synthesized. The nanoparticles demonstrated significant antimicrobial activity against the bacteria being studied, specifically S. aureus. The cytotoxic effect was observed to be the least when the concentrations were below 20 µL. A potent antioxidant effect, characterized by its maximum absorbance at 517 nm, was observed at a concentration of 50 µL. A significant anti-inflammatory effect was noted for all tested concentrations.

Conclusion:

The use of CS- and CL-mediated CuONPs demonstrates a favorable antimicrobial effect with reduced cytotoxicity, as well as improved anti-inflammatory and antioxidant effects at higher concentrations.
Dogs Barking and Babies Crying: The Effect of Environmental Noise on Physiological State and Cognitive Performance
Authors: Arruda Ana , Mesquita Carolina , Couto Rodrigo , Sousa Vanessa , Mendonça Catarina
Published: December 2023

Objective:The exposure to some environmental sounds has detrimental effects on health and might affect the performance in cognitive tasks. In this study, we analyze the effect of the neighborhood noises of a baby crying and dogs barking on the autonomic response and cognitive function.Materials and methods:Twenty participants were exposed, in separate sessions, to white noise, a baby crying, a small dog barking, and a large dog barking. During each session, heart rate, skin conductance, reaction times, spatial memory, and mathematical processing measures were taken throughout time.Results:The sounds of a baby crying and dogs barking led to significantly higher heart rates and skin conductance levels as opposed to exposure to white noise. Results were not as consistent with exposure to barking as they were to the baby. Exposure to the baby crying and dogs barking led to faster reaction times, possibly due to a facilitation by the autonomic system activation. No significant effects on spatial memory were found. Conversely, participants performed worse and slower in a mathematical task when exposed to the dog and baby sounds, than when exposed to control noise.Conclusion:Exposure to the sound of crying babies and dogs barking leads to increased sympathetic response and decreased cognitive ability, as compared to exposure to control sounds. Special attention should be paid to the mitigation of exposure to these types of noises.
Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training
Authors: Farahbakht Elaheh , Alsinani Yousra , Safari Mohammadamin , Hofmeister Martin , Rezaie Rasoul , Sharifabadi Alireza , Jahromi Maryam Koushkie
Published: December 2023

Objective: Noise pollution is a kind of stress that impairs various physiological functions. This study evaluated the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MCT) on corticosterone, interleukin-6 (IL-6), and monocyte responses to acute noise stress in male rats. Design: Forty-two male Wistar rats were divided into seven groups, including control which was assessed at the beginning, control time which was assessed simultaneously with experimental groups (CT), HIIT, MCT, HIIT followed by noise stress (HIIT+S), MCT followed by noise stress (MCT+S), and noise stress. HIIT and MCT were performed for 8 weeks. Noise stress was induced for one session. Blood samples were taken 48 hours after the last exercise session in training and CT groups and immediately after acute noise stress in stress groups of HIIT+S, MCT+S, and noise stress. Results: In response to acute noise stress, MCT and HIIT adaptations increased corticosterone, while reduced monocytes compared to CT. MCT increased basal corticosterone and IL-6 and decreased monocytes; however, in response to acute noise stress, corticosterone was higher and monocyte count was lower in the HIIT+S group. Regarding the effect of training, corticosterone and monocytes in MCT were higher than in HIIT. The serum level of IL-6 was lower in MCT than CT group, while it was not significantly different between stress groups. Conclusion: In response to noise stress, previous exercise, especially HIIT, increased stress while did not increase inflammatory and innate immune response.
Comparative study between ketamine-bupivacaine versus bupivacaine with intravenous ketamine infusion in supraclavicular brachial plexus block during upper limb surgeries
Authors: Soliman Fouad I. , Mabood Ahmed M.A. , Mahmoud Ahmed G. , Mohamed Khaled A.
Published: December 2023

Background

Theb only drawback of using local anesthetics alone for supraclavicular brachial plexus block is that postoperative analgesia lasts for a shorter period. To block brachial plexus quickly and completely, different adjuvants, including opioids, dexmedetomidine, dexamethasone, midazolam, and ketamine, had been used with local anesthetics. Aim of the study was to compare the efficacy of adding ketamine to bupivacaine versus intravenous ketamine infusion with supraclavicular brachial plexus.

Methods

Sixty studied cases planned to undergo unilateral elective upper limb surgeries using ultrasound-guided supraclavicular brachial plexus block were separated into two groups: group 1: 20 ml bupivacaine 0.5% plus ketamine (1 mg/kg) with a maximum dose of 100 mg; (the total volume is 30 ml), with the infusion of 100 ml normal saline at a rate of 100 ml/h and group 2: 20 ml bupivacaine (0.5%) plus 10 ml saline; (the total volume is 30 ml) with the infusion of ketamine 0.15 mg/kg added to 100 ml normal saline at a rate of 100 ml/h, that was stopped 5 min before the end of surgery.

Results

Visual Analog Scale (VAS), heart rate and mean arterial pressure were significantly lower at 12 h postoperatively in group 1. The onset of sensory, motor block, duration of sensory and motor block were significantly lower in group 1 compared with group 2. The time of first rescue analgesia was significantly delayed in group 1 compared with group 2. Total ketorolac requirements were significantly lower in group 1.

Conclusions

Using ketamine bupivacaine in supraclavicular brachial plexus block in upper limb surgeries is effective in improving the onset of brachial plexus block and prolonging the time of brachial plexus block with no hemodynamic changes.
Outpatient management of cervical necrotizing fasciitis: A case report and literature review
Authors: Ibrahim Muaaz Yousif , Alsuliman Dawood Ali , Almunajjim Hamad Faris , Taiwo Abdurrazaq Olanrewaju
Published: December 2023

Cervical necrotizing fasciitis (CNF) is a severe and life-threatening head-and-neck surgical and medical emergency characterized by rapid spreading gangrenous soft-tissue infection. Common debilitating conditions such as chronic malnutrition, uncontrolled diabetes, and others have been implicated in its pathophysiology resulting in serious morbidity and fatality. CNF often mandates aggressive medical and surgical management and prolonged hospitalization, followed by demanding reconstructive rehabilitation. We present the case report of a 25-year-old handicapped female who had a necrotic discharging lesion in the upper neck and was diagnosed with CNF managed successfully as an outpatient with aggressive serial debridement, copious irrigation, and intravenous antibiotics. The aims of this report were to describe the challenges of this management approach vis-a-vis the gold standard in the literature with possibility of exploring the variables that might have contributed to her survival.
Identification of acute myocardial infarction and stroke events using the National Health Insurance Service database in Korea
Authors: Cho Minsung , Lee Hyeok-Hee , Baek Jang-Hyun , Yum Kyu Sun , Kim Min , Bae Jang-Whan , Lee Seung-Jun , Kim Byeong-Keuk , Kim Young Ah , Yang JiHyun , Kim Dong Wook , Kim Young Dae , Pak Haeyong , Kim Kyung Won , Park Sohee , You Seng Chan , Lee Hokyou , Kim Hyeon Chang
Published: December 2023

OBJECTIVES: The escalating burden of cardiovascular disease (CVD) is a critical public health issue worldwide. CVD, especially acute myocardial infarction (AMI) and stroke, is the leading contributor to morbidity and mortality in Korea. We aimed to develop algorithms for identifying AMI and stroke events from the National Health Insurance Service (NHIS) database and validate these algorithms through medical record review.METHODS: We first established a concept and definition of “hospitalization episode,” taking into account the unique features of health claims-based NHIS database. We then developed first and recurrent event identification algorithms, separately for AMI and stroke, to determine whether each hospitalization episode represents a true incident case of AMI or stroke. Finally, we assessed our algorithms’ accuracy by calculating their positive predictive values (PPVs) based on medical records of algorithm-identified events.RESULTS: We developed identification algorithms for both AMI and stroke. To validate them, we conducted retrospective review of medical records for 3,140 algorithm-identified events (1,399 AMI and 1,741 stroke events) across 24 hospitals throughout Korea. The overall PPVs for the first and recurrent AMI events were around 92% and 78%, respectively, while those for the first and recurrent stroke events were around 88% and 81%, respectively.CONCLUSIONS: We successfully developed algorithms for identifying AMI and stroke events. The algorithms demonstrated high accuracy, with PPVs of approximately 90% for first events and 80% for recurrent events. These findings indicate that our algorithms hold promise as an instrumental tool for the consistent and reliable production of national CVD statistics in Korea.
Duchowe – nowoczesne – naukowe. Wartości w dyskursie krytycznoliterackim Bojana Penewa
Authors: Drzewiecka Ewelina
Published: December 2023

The article raises the question of understanding and evaluating ideas which should characterise modern literary and scientific work, as documented in the discourse of Bulgarian intellectual elites in the interwar period. The subject of the analysis is literary criticism of Boyan Penev (1887–1927), an eminent literary historian and one of the founding fathers of Bulgarian literary studies, and the notions that are evoked by the key concept of “the spiritual” are at the centre of the reflection. The interpretation is built on the assumptions of postsecular thought, and thus – it takes into account the contextual understanding of the “religious – secular” relation, as well as assumes the existence of crypto-theological entanglements in the process of creating meanings.
Innovative business models for the development of environmental entrepreneurship in the waste sector of Kazakstan
Authors: Ausharipova D. E. , Kulumbetova L. B. , Tankova E.
Published: December 2023

In modern conditions, most developed countries of the world have moved away from the linear model of economy, which leads to the depletion of natural resources, degradation of the environment and health. They have opted for a green growth strategy based on the use of innovative technologies. Despite the fact that production and consumption waste management is one of the main directions of implementation of the Concept on Transition of the Republic of Kazakhstan (RK) to a “green economy”, an effective system of collection and recycling has not been created in the sphere of municipal solid waste (MSW), which causes many problems. The aim of the study is to find opportunities for innovative business models for recycling and reuse of MSW in Kazakhstan. The theoretical significance of the article lies in the fact that based on the identification of the essence, principles and models of circular economy the necessity of active development of eco-entrepreneurship in the field of waste is justified. The practical significance lies in the problems of MSW sector and the main ways to solve them. To eliminate these problems and obstacles it is proposed to use innovative business models for waste recycling into secondary raw materials, to create conditions for the activation of the “green business”, based on the principles of closed-cycle economy. The study concluded that the MSW sector in Kazakhstan is a promising niche for the development of eco-entrepreneurship. It is recommended to use the circular principles, business models, create favourable conditions for business activities.
International tourism as a tool for inclusive development of region
Authors: Kargabayeva S. T. , Tuleubayeva M. K. , Makenova G. U. , Kirichok O. V.
Published: December 2023

The main purpose of the article is to determine the degree of interrelation of indicators of sustainable development of regions by forming models of sustainable development of tourist destinations as an inclusive tool of international tourism and building a model of sustainable development of tourist destinations. To analyze the situation, the authors consider a model that includes East Kazakhstan, Almaty regions and the city of Almaty. The study revealed the conceptual significance and influence of 6 indicators in the system of inclusive indicators of regional development. The development of tourism in an inclusive direction is one of the main directions in the national development strategies of international organizations and developed countries. Therefore, the study of international tourism as an instrument of inclusive development of regions reveals the relevance of this work. The main tools were generalizations, comparisons, economic, statistical analysis, as well as to determine each indicator of sustainability, the arithmetic mean of the indicators for determining the degree and value of the specific gravity was used, correlation analysis, Pearson linear correlation coefficients were used to correlate the indicators of sustainable development of the Republic of Kazakhstan and the regions under consideration. The authors propose an integrated approach as a tool for integration, systematization of the management process and indicators that affect the achievement of goals. It is recommended to form a mechanism in the field of ensuring the necessary level of stability of the development of tourist regions, allowing the formation of further mechanisms.
Theoretical aspects of the innovative tourism development
Authors: Tleuberdinova A. T. , Kalmenov B. T. , Mihalič T. , Salauatova D. M.
Published: December 2023

The relevance of the research topic lies in the fact that today innovation is necessary in many areas, including tourism. The developing tourism industry needs to find new approaches to increase its competitiveness. The ability to interest tourists in their activities is a guarantee of stable income and business development, which is also facilitated by innovations that will distinguish the company from others. The scale and dynamics of changes in innovation activities have determined the need for research, systematization and streamlining of scientific knowledge and approaches in this area. Thus, the object of the study was innovative processes in tourism. The purpose of the work is to reveal the essence and significance of innovative tourism. To do this, the article carried out a comprehensive analysis of existing approaches to the definition of the terms innovation, innovation, innovation process, innovation in the tourism industry. The scientific and practical significance lies in the fact that the results of the study can be used by scientists and students involved in research on the problem, tourism companies to develop and implement plans for the introduction of innovative products and services, as well as state and local executive bodies to develop strategic and tactical plans. development of the tourism industry in Kazakhstan. The study is based on the methods of theoretical analysis: analysis and synthesis, induction and deduction. The study revealed the main features of innovation in the tourism industry. The result of the analysis was the author's definition of innovative tourism.
Approach to the development of ecological tourism in specially protected natural areas on the basis of system analysis
Authors: Vukolov V. N. , Berkimbaev T. B.
Published: December 2023

The study is aimed at analyzing the development of ecological tourism in specially protected natural areas in Almaty region using a systematic approach. The purpose of the study is to comprehensively analyze and develop a strategy for the development of ecological tourism in this region. The study is based on the relationship between natural areas and tourism infrastructure, taking into account all factors and influences. To achieve the goal, various research methods were applied. A search for scientific materials on Scopus, Web of Science, ResearchGate, Google Scholar and other platforms was conducted. Keywords for the search included «ecotourism», «specially protected natural areas», «tourism», «nature protection», «system analysis», «tourism in Almaty region». The search for materials was conducted for two months, from February to May 2023. Domestic and foreign experience was studied on the materials devoted to the topic of ecological tourism development. Also during the study a comparative analysis and SWOT-analysis of ecological tourism development in specially protected areas of Almaty region was conducted. The results of the study indicate methods for the conservation of natural heritage and biodiversity in the development of ecotourism. They emphasize the importance of sustainable use of resources, compliance with environmental standards and principles of environmental responsibility. The role of local community participation in ecotourism development is also emphasized to preserve cultural heritage, ensure sustainable development and create positive interaction between tourists and local people.
The influence of digital business on the economy and innovation development in Kazakhtan
Authors: Makasheva R. S. , Tussupova L. A. , Chowdhury D. N.
Published: December 2023

The purpose of this study was to analyze the impact of digital transformation processes in business on economic performance and innovative development in the Republic of Kazakhstan. To achieve this goal, data covering 2013–2022 was used, and statistical analysis methods were applied. As part of the research methodology, an analysis of the level of digital activity of enterprises was carried out, as well as an assessment of indicators of innovation activity. Statistical models are used to study in detail the impact of digital transformation on the economy and innovation. The leading indicators that the analysis focused on were the level of use of information and communication technologies by businesses, access to Internet resources, and the participation of firms in ordering and receiving orders online. In addition, the share of innovative products in total GDP is considered. The results obtained indicate positive trends in the process of digitalization of enterprises in Kazakhstan. The impact of digital transformation on the economy, measured by GDP, was less pronounced compared to the impact on innovation. Key indicators, such as Internet access and ICT use, are identified that demonstrate the statistically significant impact of digitalization on business. The study recommends several measures, including stimulating innovation through digitalization, supporting the development of information and communication technologies, and monitoring and regulatory measures to support digital and innovative development in the Republic of Kazakhstan.
Theoretical foundations of management and functioning of the healthcare system in the Republic of Kazakhtan
Authors: Zharlygassinov T. M. , Kupeshova S. T. , Nurymova S. K.
Published: December 2023

The research topic related to the healthcare system is relevant, as it is one of the key areas of social policy and the effective management of this system is important to ensure high-quality and affordable medical care to the population. Currently, Kazakhstan is facing a few challenges and changes that require updating and developing the theoretical foundations of management in the healthcare system. The purpose of this work to analyze and assess the current state and problems in the healthcare of Kazakhstan to develop and propose theoretical foundations of management that contribute to its more effective organization. Among the used methods were the analytical, statistical, functional, system analysis, deduction, synthesis and comparison method. The study determined the organizational of the healthcare in Kazakhstan, including the roles and functions of the main institutions and responsible for the management and provision of medical care. The quality and availability of medical care in Kazakhstan is investigated. Various theoretical concepts, models and approaches to healthcare management were studied in order to develop new theoretically sound management models that take into account the unique features of the healthcare system in the Republic of Kazakhstan. This study shows that the financing of the healthcare system is an important aspect for providing affordable medicine to all citizens of the Republic of Kazakhstan. In the course of the research within the framework of this article, scientific and practical recommendations were prepared for government agencies.
Automation of digital elevation model analyzing when solving problems of economic development of karst territories
Authors: Kitaeva Marina A. , Drobinina Elena V.
Published: December 2023

The combination of geographic information systems (GIS) and remote sensing data analysis tools will make it possible to assess in a short time and with high accuracy the suitability of an area for the construction of land or linear structures in the areas where dangerous geological processes are developed. In this article we use the example of karst area in Kisherstky district of Perm region as an example to carry out the karts hazard zoning of the territory according to geomorphological indicators by analyzing ALOS-DEM digital elevation model (DEM). Patterns in the distribution of karst forms in the study area were evaluated depending on the dissection of the relief, its slope and distance from the watercourses. Based on the patterns, an integral map was constructed. The approach allows to do zoning the territory with respect to the studied danger geological process in a short time and with high accuracy, which is due to the use of patterns of forms distribution in the analysis.
Using the method of image decomposition based on topological features for processing satellite images
Authors: Eremeev Sergey V. , Abakumov Artyom V. , Krainov Sergey A. , Kozlov Alexey S.
Published: December 2023

The problem of interpretation of spatial data on satellite images is considered in the article. It is proposed to use the decomposition of images by topological features to highlight objects of interest, global and detailed structures on satellite images. The description of the method and the features of its implementation for creating a software product with effective algorithms for processing big data are given. The functionality of the developed software, which includes the classification of objects on satellite images, segmentation, binarization, noise removal is described. It is shown that these algorithms are built on a single theoretical basis in the form of a topological decomposition. Examples of using the program for segmentation and binarization of satellite images from urban neighborhoods are demonstrated.
Combining Computer Vision, Artificial Intelligence and 3D Printing in Wheelchair Design Customization: The Kyklos 4.0 Approach
Authors: Gharra Mahmoud , Rebahi Yacine , Rizzi Luca , Zournatzis Ilias
Published: December 2023

In the current paper, we present our work towards developing a solution combining computer vision and AI to support footrest design customization in the wheelchair industry. Wheelchairs and postural systems are complex and often user centric in the design process. Those products require a wide range of adjustments to adapt to the various anthropometries and disabilities of patients. Most commercial products, dedicated to severe disability, also include a series of additional elements, designed to keep the patient in a comfortable but “fixed” position. Such systems do not allow to “fix and maintain” the position of patient foot, especially for patients who have no control over their lower limbs. For that reason, it becomes essential to supply wheelchairs with specific elements to hold patient's shoe in place. Commercial foot supports are typically developed on standard sizes and do not always cover the entire population. In addition, those designs are based on standard shoes, thus they do not lend themselves well to adapting to special shoes or orthopedic shoes.  Feet final position therefore becomes a key element in correct postural management. In this paper, we investigate the use of computer vision and AI to correctly define customization parameters of the footrest. The proposed design has been developed based on the specifications received from the Pro Medicare S.r.l[ https://www.promedicare.eu/en/] orthopedic technicians. We present suitable algorithms, design principles and well defined components towards the implementation of our proof of concept. We also present the testing activities we have undertaken and the obtained performance results.
 
Received: 26 June 2023 | Revised: 20 July 2023 | Accepted: 31 July 2023
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
 
Author Contribution Statement
Mahmoud Gharra: Conceptualization, Software, Validation, Formal analysis, Investigation, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision. Yacine Rebahi: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Writing - original draft, Writing - review & editing, Supervision, Project administration, Funding acquisition. Luca Rizzi: Conceptualization, Methodology, Validation, Investigation, Resources, Data curation, Writing - review & editing, Visualization, Supervision, Project administration, Funding acquisition. Ilias Zournatzis: Conceptualization, Methodology, Software, Validation, Investigation, Resources, Data curation, Writing - review & editing, Visualization, Supervision, Project administration, Funding acquisition.
Evaluación de una prueba de reacción en cadena de la polimerasa múltiplex anidada para la detección de HTLV-1
Authors: Serrano-Segura Kevin , Miranda-Ulloa Eduardo , Romero-Ruiz Soledad , Cárdenas-Bustamante Fany , Quiroz-Ruiz Hans Ramón
Published: December 2023

El Perú es un área endémica al virus linfotrópico T humano tipo 1 (HTLV-1) y para su confirmación diagnóstica se usa pruebas serológicas que pueden dar resultados no concluyentes. Objetivos: evaluar una prueba de PCR múltiplex anidada para diagnosticar el HTLV-1. Métodos: la validación de la PCR se realizó con primers dirigidos a las regiones Pol y LTR del HTLV-1. Se empleó el gen β-globina como control endógeno interno y el límite de detección se evaluó con células MT2. Los parámetros de precisión diagnóstica se evaluaron frente a 95 muestras sanguíneas de Referencia. Resultados: la prueba evaluada obtuvo un límite de detección de 0.5 ng/μL de ADN; sensibilidad diagnóstica=97.1%, especificidad diagnóstica y analítica=100%, vpn=97.2%, vpp, repetibilidad y reproducibilidad=100%; Kappa, Índice Youden=0.97. Conclusiones: la prueba evaluada presenta un alto rendimiento diagnóstico y debido a su bajo costo se recomienda su implementación en el algoritmo del diagnóstico de HTLV-1 en Perú.
Satisfacción de los estudiantes con los procesos de elaboración de la tesis de licenciatura
Authors: Castro-Rodríguez Yuri
Published: December 2023

Objetivos: describir la satisfacción con los procesos de la tesis que presentan los estudiantes del pregrado de la Facultad de Odontología.Métodos: estudio transversal donde participaron 68 estudiantes de la Universidad Científica del Sur que se graduaron en el 2021. Se utilizó una escala que recopiló las experiencias sobre el desarrollo de una investigación que involucró: supervisión de la tesis, desarrollo de habilidades, clima intelectual, expectativas, infraestructura y evaluación de la tesis. Las variables fueron comparadas según el sexo, rendimiento académico y experiencia investigativa de los estudiantes. Resultados: la satisfacción general tuvo un puntaje de 65,78 ± 4,29 (Rango: 57-78), considerándose como “moderada”. Las mujeres tuvieron un mejor puntaje de satisfacción (p>0,05). El promedio general de la satisfacción fue 2,74 ± 0,81, obteniéndose un promedio de 2,08 ± 0,76 para la dimensión supervisión, 2,05 ± 0,66 para la dimensión clima intelectual, 4,15 ± 0,23 para la dimensión expectativas, 1,92 ± 1,17 para la dimensión infraestructura, 3,73 ± 0,91para la dimensión habilidades y 2,81 ± 0,86 para la dimensión evaluación de la tesis. Conclusiones: los estudiantes del pregrado perciben como “moderado” la satisfacción con los procesos de elaboración de una tesis universitaria, con una puntuación por debajo del promedio de lo esperado. No se encontró una asociación significativa entre el grado de satisfacción con el proceso de realización de la tesis y las características de los estudiantes.
PEMANFAATAN BOILER MINI HEMAT ENERGI BERBAHAN BAKAR LIMBAH SERBUK GERGAJI DAN LIMBAH AMPAS TEBU UNTUK MEMASAK PADA INDUSTRI RUMAH TANGGA
Authors: THAMRIN ISMAIL , YANI IRSYADI , GUNAWAN GUNAWAN , ARIFIN AMIR , NUKMAN NUKMAN , BARLIN BARLIN , PUSPITASARI DEWI , ASTUTI ASTUTI , PRATIWI DIAH KUSUMA , PARAMITHA EKA UTAMI NURHABIBAH
Published: December 2023

Boiler mini ini dapat juga berfungsi sebagai tungku masak biasa, yang sering digunakan masyarakat dengan menggunakan kayu sebagai bahan bakarnya. Bedanya boiler ini menggunakan limbah dari serbuk kayu dan ampas tebu sebagai bahan bakarnya. Cara kerja tungku ini menggunakan tekanan uap yang dihasilkan dari tangki air yang terdapat dalam tungku. Tekanan uap ini mendorong bahan bakar alternatif yang digunakan untuk langsung masuk kedalam ruang bakar. Kita hanya perlu mengontrol tingkat level air yang ada didalam tungku, agar tekanan uap yang dihasilkan selalu dalam kondisi tinggi. Dengan jumlah kalori bahan bakar yang sama, tungku ini dapat menghemat pengeluaran untuk membeli kayu.
Study On Electrolyte of Low Temperature Sodium-Ion Battery
Authors: Chang Bohao
Published: December 2023

With the rapid development of electronic devices, energy storage systems with excellent performance are required. To be used in cold climates and high-altitude areas, it is required that the battery should work stably and operate safely even when the temperature drops below freezing point. Sodium-ion batteries arouse great attention, because of their high safety, good capacity in both high and low-temperature environments, along with their abundant sodium resources in the earth's crust. But for practical applications, the kinetics of sodium-ion batteries become slow when working at low temperatures. The performance deteriorates with the temperature decreases. Therefore, researchers have carried out a lot of research to overcome these problems in the low-temperature environment. For example, the energy storage performance of sodium-ion batteries can be improved by optimizing the positive and negative electrodes, separators, and electrolytes. Among them, optimizing the electrolyte is critical to improving the energy storage performance of sodium-ion batteries. Because the electrolyte is an important part, which is in contact with each part of the battery as a medium, which is mainly composed of solvents, electrolyte salts, and additives. During the charge/discharge processes of the battery, the electrolyte plays a role to act as an ionic conductor to transfer Na + between the positive and negative electrodes and link then together. Additionally, the electrolyte will also directly participate in the reaction on the electrode surface and form SEI film. Thus, it is one of the most economical and effective means to enhance the low-temperature performance by modifying the electrolyte. This paper, summarizing the reports on the electrolyte of low-temperature sodium-ion batteries at home and abroad, sorting out and analyzing the solid, liquid, and gel electrolytes, clarifies how to making the electrochemical performance of sodium-ion batteries better by optimizing electrolytes.
Exploration of Adaptable Protection Transformation and Vitality Regeneration Path for Old Boiler Houses in Universities
Authors: Liu Yan'an , Zhao Qi , Zhang Rui , Wang Yun
Published: December 2023

This project is located within the residential area of Dongda Town in Chang'an District, Xi'an City, China. The project involves the old boiler room supporting the original building, which has been completed for 15 years. With the gradual development and formation of surrounding conditions, the functions of this building have gradually retired from the historical stage and become vacant. The original building's buildings, large equipment, process flow lines, trace environment and other facilities remain intact. Based on the protection and preservation of the original state-owned assets, while also reactivating the functions, supporting facilities, and related auxiliary values of the land, it is planned to carry out protective improvement and renovation on the industrial building and surrounding environment of this equipment, and provide a preliminary design plan.
Research on Key Technology of Mechanical Construction of Connecting Passages
Authors: Wang Junyong , Hang Li , Wang Guozheng , Chao Han
Published: December 2023

Conventional connecting passages construction usually uses mining method with freezing or grouting method of reinforcement, generally has a long construction period, high construction risk, costly problems, which has an urgent need for a mechanical way of construction technology to improve the speed and quality of construction. The critical technologies for the mechanical construction of connecting passages mainly include the design of the main tunnel and the connecting-passage segment, TBM fully enclosed launching and receiving, the waterproof design, and the design of the built-in pump chamber of the TBM. Its construction process mainly includes TBM assembly, sleeve installation, breaking of the tunnel door, the tunnel boring, the machine receiving, and the fabrication of the tunnel door seal. Based on the above vital technologies analysis, this paper demonstrates the significant advantages of the mechanical construction of the connecting passage with practical construction cases, which provides an essential reference for the subsequent research.
Identification and Pathogenicity of Rhizoctonia solani Isolates Causing Leaf and Stem Rot in Three-Leaf Ladybell
Authors: Kim Wan-Gyu , Choi Hyo-Won , Lee Gyo-Bin , Cho Weon-Dae
Published: December 2023

In 2020 and 2021, we surveyed diseases of three-leaf ladybell (Adenophora triphylla) plants grown in fields at two locations in Korea. During the disease surveys, severe leaf rot symptoms were observed on the young plants in Hongseong, and stem rot symptoms on the adult plants in Cheolwon. The incidence of leaf rot was 5‒60%, and that of stem rot 1‒10%. We obtained 6 fungal isolates each from the leaf rot lesions and the stem rot lesions. All the isolates were morphologically identified as Rhizoctonia solani. Anastomosis test and investigation of cultural features of the fungal isolates revealed that the isolates from the leaf rot lesions corresponded to R. solani AG-1(IB), and those from the stem rot lesions to R. solani AG-2-2(IIIB). Two isolates each of R. solani AG-1(IB) and AG-2-2(IIIB) were used for DNA sequence analysis and pathogenicity test to three-leaf ladybell plants through artificial inoculation. The anastomosis groups and cultural types of the R. solani isolates were confirmed by the sequence analysis. The pathogenicity tests revealed that the isolates of R. solani AG- 1(IB) caused only leaf rot symptoms on the inoculated plants, and those of R. solani AG-2-2(IIIB) leaf rot and stem rot symptoms. The induced symptoms were similar to those observed in the fields investigated. Leaf and stem rot of three-leaf ladybell caused by the two anastomosis groups and cultural types of R. solani is first reported in this study.
Effective Control Strategy against Bacterial Blight on Carrot
Authors: Kang Hyun Su , Kim Mi-Jin , Shin Yong Ho , Jeun Yong Chull
Published: December 2023

Bacterial blight of carrot caused by Xanthomonas hortorum pv. carotae (Xhc) is one of the serious diseases of carrot, of which control measures has not been still established in the domestic farm. In this study, in order to select effective sterilizer for bacterial blight of carrots, three antibiotics such as streptomycin, oxolinic acid, kasugamycin, two copper compounds like copper hydroxide and copper sulfate basic and three rhizobacteria Burkholderia gladioli MRL408-3, Pseudomonas fluorescens TRH415-2 and Bacillus cereus KRY505-3 were selected to investigate their direct antibacterial effects using artificial media, aiming to identify effective pesticides against Xhc. Among them, treated medium with antibiotics such as streptomycin, oxolinic acid, and the antagonistic rhizobacteria MRL408-3 were formed inhibition zone. The agrochemicals and the rhizobacteria MRL408-3, which showed antibacterial effects on carrot leaves, pre-treated on the carrot leaves and then inoculated with Xhc. High control effects were shown on the carrot leaves pre-treated with both streptomycin and oxolinic acid. Scanning electron microscopy images of the carrot leaf surfaces showed that the population of bacteria decreased significantly on leaves pre-treated with streptomycin and oxolinic acid. From these results, it can be inferred that antibiotics like streptomycin and oxolinic acid exhibit superior control effects compared to other agents. This study provides valuable insights towards establishing an effective control system for bacterial blight of carrot.
First Report of Pectobacterium brasiliense Causing Bitter Melon Soft Rot Disease in Korea
Authors: Park Kyoung-Taek , Ten Leonid N. , Hong Soo-Min , Back Chang-Gi , Lee Seung-Yeol , Jung Hee-Young
Published: December 2023

In the Goesan region, located in Chungcheongbuk-do, Korea, a significant outbreak of soft rot infections was documented in August 2021, affecting fruits of Momordica charantia, commonly known as bitter melon or bitter gourd. The symptoms included a noticeable transition to yellowing in the affected fruits, eventually leading to their collapse. The bacterial strain KNUB-09-21 was isolated from the diseased fruits. Molecular analysis, using the sequences of the 16S rRNA region and three housekeeping genes (dnaX, recA, and leuS), along with the results of compound utilization in the API ID 32 GN system, provide strong evidence for the identification of the isolate KNUB-09-21 as Pectobacterium brasiliense. The pathogenicity of strain KNUB-09-21 on M. charantia was confirmed through a controlled inoculation test. Within two days, inoculated fruits displayed soft rot symptoms closely resembling those observed in naturally affected fruits. This is the first report of soft rot on M. charantia in Korea.
It’s Nice to Meet You: Contextual Configuration on Formal and Informal Introductions
Authors: Riyanto Agus , Ardianto Ardik
Published: December 2023

The discourse of introduction is a discourse exploiting full of contextual meanings. By means of two approaches, viz. situational context and contextual configuration, this paper aims to delve deeper into the discourse of formal and informal introductions in everyday English conversation. Both discourses are taken from the book Everyday Conversation. The data were analyzed from two paradigmatic approaches, i.e., situational context with the components of field, tenor, and mode, and contextual configuration with the three main maxims of OOI (obligatory, optional, and iteration). Based on the careful analysis, the findings demonstrate that both introduction discourses, whether formal or informal ones, are built on the foundation of two types of elements, namely obligatory and optional, which are interwoven within a potential common structure of the following contextual configuration: (OE). [IR^IG1^IG2]. (IE)(context-dependent) > [(R)^(RC)]. Ultimately, through this paradigmatic approach to the discourse of introduction, it arrives at an understanding that the relationship between language and its contextual use is that of mutuality; shall language need context in the process of interpretation, the context ipso facto needs language to manifest per se.
Understanding the Match: The Effect of Signaling, Demographics, and Applicant Characteristics on Match Success in the Orthopaedic Residency Application Process
Authors: Kotlier Jacob L. , Mihalic Angela P. , Petrigliano Frank A. , Liu Joseph N.
Published: December 2023

Introduction:

As of the 2022 to 2023 match cycle, orthopaedic residency programs began offering applicants 30 signals as part of a preference signaling program. Many have assumed that signals would become powerful tools in the match process, yet no objective data currently exist analyzing their effect. This study aims to provide such analysis while also offering comparisons with other factors affecting match success.

Methods:

Self-reported survey data on applicants and applications from 2017 to 2023 from the Texas Seeking Transparency in Application to Residency database were queried. Variables associated with receiving interviews and match success were analyzed using two-sided Student t-tests, chi-squared tests, variance ratio testing, and receiver operating characteristic analysis.

Results:

Compared with 2017 to 2022, 2023 applicants submitted fewer applications (61.8 versus 78; P < 0.001), received fewer interview offers (11.6 versus 13.8; P < 0.001), and interview offers were spread more evenly among applicants (SD, 6.82 versus 9.10; P < 0.001). For 2023 applications, odds of securing an interview were increased most by away rotations (odds ratios [OR] 61.8; P < 0.001), use of a signal (OR, 9.61; P < 0.001), and geographic connection (OR, 4.70; P < 0.001). Female applicants received more interview offers from signaled programs than their male counterparts (11.2 versus 8.94; P = 0.003). Applicant variables most predictive of match success in 2023 were interview offers (area under the receiver operating characteristic curve [AUC] = 0.802), step 2 CK score (AUC = 0.673), and step 1 score (AUC = 0.648).

Discussion:

The preference signaling program seems to be accomplishing its goals of reducing applications and more evenly distributing interviews. Away rotations, signals, and geographic connections represent the strongest predictors of applications resulting in a successful match. Applicants must use their signals carefully to maximize their chance of success.

Level of evidence:

Level III.