bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of A-Smart Lu’bah: An Arabic Language Gamification for Teaching Grammar Based on Sentence Pattern Formula Modules
Authors: Ramli Saipolbarin , Abdul Ghani Mohammad Taufiq , Awang Hamat Mohd Zawawi
Published: February 2025

A-Smart Lu’bah is a gamified tool designed to facilitate the mastery of basic Arabic grammar (Arabic grammar) through an engaging “learn while playing” approach. This study focuses on four core grammatical topics: Idafiy phrase, Na’tiy phrase, verb sentences, and noun sentences, which are further divided into eight sub-topics modeled as interactive language games. The instructional design follows the ADDIE framework and integrates the Technology Integration Model (TIP) to enhance pedagogical effectiveness. The study involved 52 undergraduate students enrolled in the Arabic Language with Education program at Universiti Pendidikan Sultan Idris (UPSI), specifically from the 2023/2024 academic intake. A mixed-methods research design was adopted, utilizing pre-test and post-test evaluations, structured questionnaires, and observational data. The findings indicate statistically significant improvements in the treatment group that utilized the A-Smart Lu’bah gamification compared to the control group, which relied on traditional teaching methods. Students in the gamified learning environment demonstrated higher scores, suggesting the efficacy of A-Smart Lu’bah in enhancing grammatical competence. Furthermore, the gamification framework integrates interactive, collaborative, and student-centered learning principles, aligning with Education 4.0 objectives. While the findings underscore the module’s potential, limitations such as the small sample size and short intervention period suggest the need for further longitudinal studies to confirm and expand the findings. These features not only make grammar learning more accessible and effective but also sustain long-term engagement in Arabic language education. This study underscores the potential of gamified tools to transform traditional pedagogies, promoting an innovative and technology-driven approach to language learning.
Blockchain, Digital Assets and Currencies: Modern Aspects of Use and Accounting in the Russian Federation
Authors: Nagumanova Regina , Plotnikova Lyubov , Davletshina Alsou , Rubanov Vladislav
Published: February 2025

The primary objective of the research is to conduct a detailed examination of blockchain and digital financial assets, including their classification and methodology. Additionally, research addresses the key risks associated with assessing and reflecting digital assets in financial reporting, providing recommendations for managing these risks. Furthermore, attention is payed to mining activities in the Russian Federation, the existence of legislative gaps in this field and potential solutions to these issues. Various theoretical and practical research methods were used to achieve the results: analytical method to study the fundamental concepts and classification of digital financial assets; observation, comparison, experiment for risk analysis and development of recommendations in the field of accounting and reflection of digital assets; normative-legal method to study legislative gaps and propose possible solutions; comparative analysis to compare legislation in the Russian Federation and other countries. The research results include a detailed study of the concept of digital assets, their classification and methodology, analysis of identified risks, development of management measures, study of mining and legislative gaps, as well as proposal of solutions to improve legislation and accounting methods. This research holds significance for entrepreneurs actively using or planning to integrate digital assets, as well as for professionals engaged in blockchain and digital assets’ utilization in business practices and their reflection in accounting and financial reporting.
A Study of Consumer Attitude and Their Purchase Intention with Reference to Tier 2 Consumers of India
Authors: Gupta Sudha , Priti Chetna
Published: February 2025

India’s economic landscape continues to evolve, Tier 2 cities like Patna, Bhopal, and Nagpur are emerging as key markets with unique consumer behaviors. This study aims to investigate the factors influencing consumer purchase intentions in these cities, focusing on product quality, brand loyalty, price sensitivity, and social influence. The study employed a cross-sectional survey-based research design, gathering data from 149 respondents across Patna, Bhopal, and Nagpur using a structured questionnaire. The questionnaire measured consumer attitudes toward product quality, brand loyalty, price sensitivity, and social influence, alongside demographic information. Data were analyzed using descriptive statistics, Pearson correlation, and multiple regression analysis to assess the impact of these factors on purchase intention. The analysis revealed that product quality (β = 0.45, p < 0.001) and brand loyalty (β = 0.38, p < 0.01) were the strongest predictors of purchase intention. Price sensitivity (β = 0.29, p < 0.05) also had a significant effect, though to a lesser extent. Social influence was moderately associated with purchase decisions (r = 0.38, p < 0.05), while aspirational consumption showed a growing impact (r = 0.48, p < 0.01). This study highlights the importance of product quality and brand loyalty in shaping purchase intentions among Tier 2 city consumers, with price sensitivity and aspirational consumption also playing crucial roles. As Tier 2 markets continue to expand, brands that prioritize quality and foster customer loyalty are likely to succeed.
Protocole ODIN pour la surveillance des pathogènes environnementaux dans les pays sub-sahariens
Authors: Miller Taru ,   Finnish Institute for Health and Welfare (THL), Finland, Pitkänen Tarja ,   Finnish Institute for Health and Welfare (THL), Finland, Nyholm Outi ,   Finnish Institute for Health and Welfare (THL), Finland, Valkama Kristiina ,   Finnish Institute for Health and Welfare (THL), Finland, Christian Tahita Marc ,   Clinical Research Unit of Nanoro/ IRSS-DRCO, Burkina Faso, Baraka Vito ,   The National Institute for Medical Research (NIMR), Tanzania, Maketa Vivi ,   University of Kinshasa, DRC, Lyimo Eric ,   The National Institute for Medical Research (NIMR), Tanzania, Sebukoto Hillary ,   The National Institute for Medical Research (NIMR), Tanzania, Lompo Palpouguini ,   Clinical Research Unit of Nanoro/ IRSS-DRCO, Burkina Faso, Kabena Melissa ,   University of Kinshasa, DRC, Krolicka Adriana ,   Norwegian Research Centre, Norway
Published: February 2025

Dans le cadre du projet ODIN, la mise en place d'un système de surveillance environnementale pour de multiples pathogènes humains est en cours dans trois pays subsahariens: Tanzanie, Burkina Faso et République démocratique du Congo (RDC). L'objectif est de développer un système harmonisé de surveillance des eaux usées et de l'environnement (WES) pour desservir ces régions, avec un potentiel d'expansion dans d'autres pays d'Afrique subsaharienne. Le projet ODIN a publié un livrable 2.2 qui résume la planification et le développement de la stratégie de surveillance environnementale, y compris la phase pilote de la surveillance des eaux usées et de l'environnement pour les pathogènes prioritaires sélectionnés. Ce document a été produit dans le cadre du Work Package 2 du consortium ODIN, sous la tâche 2.2 Développer une proposition pour une stratégie de surveillance environnementale rentable, en étroite collaboration avec la tâche 2.1 Rassembler des informations sur les systèmes de surveillance clinique et environnementale existants, la tâche 2.3 Préparer des conseils et un manuel pour les investigations microbiologiques, et la tâche 2.4 Recueillir les données de surveillance environnementale. Le rapport fournit également des informations sur la manière dont les performances des méthodes de laboratoire ont été vérifiées et la production de bibliothèques de séquences métagénomiques testée avec des échantillons environnementaux au cours de l'échantillonnage pilote en Tanzanie, au Burkina Faso et en RDC.
Determining the Classroom Needs of School-Based Agricultural Education Teachers in Minnesota
Authors: Rada Lavyne L. , Smalley Scott W.
Published: February 2025

Retaining quality SBAE teachers is key to the success and growth of the agricultural industry. Given the connection between SBAE teacher perceived competence and professional commitment (Palmer, 2020; Rada, 2023), it is vital to explore the perceptions of competence of teachers concerning their classroom. Using a Borich needs assessment model, the purpose of this study was to evaluate the perception of Minnesota SBAE teachers in the areas of teaching, classroom management, and technical agriculture to identify professional development needs. The SBAE teachers who participated in this study utilized various sources of professional development to enhance their competence as educators. Agriculture teachers' association workshops and school in-service workshops were their main sources of professional development. Most respondents (69.2%) had also participated in the Teacher Induction Program (TIP) as an early-career teacher. Managing student behaviors, motivating students to learn, proper implementation of IEPs for students with disabilities, integrating current advances in agricultural technology into the curriculum, teaching in an agricultural mechanics laboratory, and teaching knowledge and skills in biotechnology were identified as the top six professional development needs. Our results showed limited differences in professional development based on years of SBAE teaching experience. In addition to continued content-focused trainings, professional development focused on pedagogy and student engagement are recommended as focus areas for professional development.
ROLE OF MULTIDISCIPLINARY TEAM MANAGEMENT IN WOMEN WITH PLACENTAL CHORIOANGIOMA AND VALVULAR HEART DISEASE
Authors: Rehman Attiya , Shamoona Dr , Nadeem Shafaq
Published: February 2025

Chorioangioma, a non-trophoblasticbenign tumor without any malignant tendency,originates from the placenta and can affect fetal outcome. The diagnosis is usually made in the second trimester of pregnancy. The tumor is usually on the fetal side in close connection to the umbilical cord site andprotrudes into the amniotic cavity. These can either be small (less than five centimeters) or large (more than five centimeters) tumors with favorable and unfavorable fetal outcomes,respectively. The larger tumorcan cause preterm labour, placenta previa, pre-eclampsia, polyhydramnios, hemorrhage in mothers. At the same time,fetus complications can include growth restriction, thrombocytopenia, cardiomegaly, anemia, fetal hydrops,etc. The diagnosis can be made earlier by using color Doppler and earlier intervention can be done through multidisciplinary team management to reduce maternal andfetal complications. Here, presenting a case report of a pregnant patient with Rheumatic heart disease having Chorioangioma of size 5.0x3.0 cm diagnosed at nineteen weeks at the time of anomaly scan. She was kept for regular follow-up until 33 weeks when the umbilical artery Doppler scan revealed absent end diastolic flow and emergency LSCS was performed under steroid cover. A female baby was born witha birth weight of1.8 kg (low birth weight) and admitted to theneonatal unit. At the same time,mother was taken to CCU and remained there for fifteen days under extensive treatment by the multidisciplinary team including cardiologist, intensivist and internal medicine specialist. The multidisciplinary team management increased the maternal as well as fetal outcome.KeyWords:Pregnancy, Placenta, Heart disease
PATIENT SATISFACTION REGARDING EMERGENCY DEPARTMENT SERVICES AT COMBINED MILITARY HOSPITAL (CMH) LAHORE –A CROSS-SECTIONAL STUDY
Authors: Khan Sehar Khauteja , Bokhari Uswah , Khan Shahmir Ahmad , Shoaib Uswah , Haris Rana Zaid , Omer Zainab
Published: February 2025

Background: To measure the level of satisfaction of the patients that present to the emergencydepartment of CMH Lahore,as feedback from the patients themselves is the most reliable source of information regarding the healthcare system's shortcomings.Material and Methods: We conducted a cross sectional analytical study over 6 months at theaccident and emergencyA&E department of CMH Lahore. The investigators administered patients that presented to the A&E department self-designed questionnaires in a non-contrived setting and participants were enrolled using simple convenience sampling. Beforeconducting this definitive research, a pilot study was conducted where the time is taken to fill in the questionnaire and its practicality was accessed. The inclusion criteria included all patients presenting to the A&E department, over the age of 18 years, oriented in time, place and person. The patients that presented to all other departments, younger than 18 years and in a state of delirium, confusion and unconsciousness were excluded from the study.The questionnaire assessed demographic data, physical environment, accessibility, attitude of healthcare providers towards patients and overall satisfaction.Results: Among a total of 277 respondents, 67.9% were males and 32.1% were females. Maximum satisfaction was documented in the area of health care the professional's attitudes towards the patients where 81.6% were satisfied. There was a significant association between level of dissatisfaction and age with a p-value < 0.015 where 37.9% respondents were between 15-25 years of age. Patients who were overall satisfied with the A&E department were 88.8%.Conclusion: Patients were predominantly satisfied with the healthcare facilities provided at the A&E department other than a few basic facilities including physical environment and information regarding prescribed medicine.Key Words: Patient satisfaction,Gender, Emergency
THE IMPACT OF HYDROXYPROGESTERONE CAPROATE ON ADRENAL CORTEX THICKNESS IN DEVELOPING RATS
Authors: Iqbal Javaid , Siddique Asma , ud Din Hafiz Moeen
Published: February 2025

Background: Hydroxyprogesteronecaproate, a drug used commonly in Gynaecology and Obstetrics,has been shown to increase the weight of developing rat adrenal glands.This research was undertaken to observe changes in the various zones of the adrenal cortex with anincrease in the thickness of the adrenal cortex.Material and Methods:Hydroxyprogesterone caproate was administered to two experimental groups at doses of 10mg and 25mg per kgbody weightintraperitoneally,while the third group was the control group and didn't receive any hydroxyprogesterone caproate.Onseventh day following delivery, the offspring were sacrificed. The adrenal glands were dissected and after proper fixation and staining, the thicknesses of various zones of the adrenal cortex were noted.Results:It was observed that the mean thickness of the adrenal cortex was increased in experimental groups as compared tothe control group.Conclusion:The research revealed that hydroxyprogesterone caproate impactedrat pups' adrenal cortexby increasing its thickness and accelerating its maturity when used in a critical phase of the development of the adrenal gland. Key Words: Adrenal cortex,Rats, Corpus luteum
BEYOND THE BOOKS: PRIORITIZING EMOTIONAL INTELLIGENCE IN MEDICAL STUDENTS
Authors: Rashid Maryam , Yousaf Neelofar
Published: February 2025

BEYOND THE BOOKS: PRIORITIZING EMOTIONAL INTELLIGENCE IN MEDICAL STUDENTS
INFLUENCE OF COVID 19 ON KNOWLEDGE AND PRACTICES OF STUDENTS AND EMPLOYEES REGARDING INFECTIOUS DISEASES AT A PRIVATE MEDICAL COLLEGE
Authors: Mansoor Hajra , Bint-e-Riaz Hunniya , Pervaiz Iqra , Asif Jaweria , Azam Fatima , Omer Zainab
Published: February 2025

Background: The coronavirus pandemic with its rapid transmission and multiple variants wreaked havoconthe health and socioeconomic infrastructure of countries. The struggle to control the spread was a massive problem not only for people at the individual level but for governments while imposing restrictions as well. This descriptive study, hence, aims to evaluate knowledge, attitude and practices during covid-19 and apply itto other impendinginfectious diseases. Material and Methods: In this descriptive cross-sectional study an online questionnaire consisting of 17 items broadly addressing awareness regarding the viral variants, understanding of and adherence to protocols as well as knowledge about vaccines was administered to 335 students and employees of CMH Lahore Medical Collegefrom January, 2022 to March, 2022. Participants were selected by nonprobability convenient sampling. Results: The results showed that out of 335 responses, 275 (82.1%) were studentresponses and the remaining 60 (17.9%) were responses from the employees. The results showed that although 47.5%of employees did not consider the new variants to cause more severe illness but about 85%were motivated enough to continue practicing personal protection and adhere to the control measures.Conclusion: With the results gathered by our study, it is believed that although attitudes towards control measures have improved individuals still need to practice adherence to preventive strategies set by governments for not only corona virusvariantsbut for other transmissible diseases as well to reduce the risk of future pandemics. KeyWords: Viral diseases,Pandemic, Knowledge, Covid-19
C-REACTIVE PROTEIN
Authors: Hamid Naila , Aslam Muhammad Sohail
Published: February 2025

C-reactive protein (CRP) is synthesized in the liver after macrophages and T-lymphocytes secrete interleukins.It is an acute phase protein,and the normal concentration ranges from0.8 mg/L to 3 mg/L. It is used as a markerof inflammation. CRP levels are increased in infection,trauma, necrosis, malignancy,and allergic reactions.Patients havingelevated CRP areat risk of sufferingfrom diabetes, hypertension,andcardiovascular disease. CRP levels are reduced after exercise. COVID-19 positive patients also had increased CRP levels in Wuhan, China.Key Words:C-reactive protein, Necrosis, CVID-19, Hypertension
Assessment of the Prevalence of Clinical Manifestations of Onchocerciasis and Evaluation of Transmission Interruption in Sentinel Communities in Imo State, Nigeria After 20 Years of Mass Drug Administration
Authors: C. M.U. Ajero, , C. C. Ibekwe, , B.E.B. Nwoke, , U. N. Chigbo,
Published: February 2025

Onchocerciasis remains a public health concern in Nigeria, though community-directed ivermectin interventions have significantly improved outcomes. This study evaluated onchocerciasis prevalence and transmission status in nine endemic communities in Imo State after 20 years of ivermectin distribution. Conducted from April 2022 to March 2023, the research focused on three LGAs: Ehime (Nzerem Ikpem and Umueze 1), Okigwe ( Amano, Amuro, Ibii,Ihube and Umulolo) and Ezinihitte ( Itu and Udo), communities along the Imo River. A total of 652 respondents were assessed for clinical manifestations, and the Ov16 IgG4 rapid diagnostic test was performed on 225 participants. Black fly abundance and microfilaria infection rates were also evaluated. Findings revealed a 94.03% reduction in nodules from a pre-control rate of 25.67% to 2.15%, with Okigwe LGA showing the highest reduction (95.28%). Clinical manifestations, including nodules (1.54%), leopard skin (0.15%), and onchodermatitis (0.46%), were more frequent among older residents and males (2.31%) compared to females (1.81%). No manifestations were observed in individuals aged 5–30 years or among civil servants, traders, and students. The Ov16 IgG4 test detected no Onchocerca volvulus antibodies. Of the 1,022 black flies captured, none carried infective larvae (L3), indicating a 0% infectivity rate.This study highlights the success of ivermectin in reducing onchocerciasis prevalence and interrupting transmission. However, ongoing surveillance and public health education are crucial to prevent reinfection and maintain progress in these communities.
From anesthesia to healing: the potential of topical sevoflurane in enhancing wound repair
Authors: Çelik Erdi , Arslankoz Sehbal , Koyuncu Pınar , Öğüş Elmas , Polat Reyhan , Dönmez Aslı
Published: February 2025

Aims: Sevoflurane is a volatile anesthetic agent commonly used for the induction and maintenance of general anesthesia. Recent case reports and case series have highlighted the analgesic and anti-inflammatory properties of sevoflurane when applied topically to venous ulcers, diabetic wounds, and infected wounds. This study investigates the therapeutic effects of topically applied sevoflurane on thermal burn wounds in rats, focusing on inflammatory responses and wound healing processes.
Methods: Twenty-one male Wistar Albino rats underwent the induction of a second-degree thermal burn covering 3 cm² on the interscapular skin. The animals were randomized into three groups: the experimental group (Group S) received 3 ml of topical sevoflurane (1 ml/cm²), the control group (Group I) received 3 ml of isotonic saline, and the sham group (Group K) received no treatment. Plasma concentrations of TNF-?, IL-1ß, IL-6, and IL-10 were measured at baseline, and on days 7 and 14 post-injury. Histopathological evaluations of the burn sites were conducted on day 14, assessing for active and chronic inflammation, granulation, and fibrosis.
Results: All rats in the study maintained similar age and weight profiles across the groups. Histologically, the sevoflurane group exhibited significantly reduced chronic inflammation and enhanced granulation and fibrosis compared to controls. Immunologically, IL-6 and IL-10 levels were elevated in the isotonic group but did not differ significantly from baseline in other groups. Plasma cytokine levels were comparable across all groups.
Conclusion: Topical sevoflurane appears to promote wound healing by modulating inflammatory responses and enhancing tissue repair processes in a rat burn model. These findings indicate that sevoflurane may serve as a beneficial adjunctive therapy in the management of burn injuries and general wound care. Given its established anti-inflammatory effects when inhaled, there is a compelling need for further research to investigate the potential benefits and mechanisms of topical sevoflurane application. Such studies could provide valuable insights into optimizing wound healing processes and improving patient outcomes.
Retrospective investigation of cases diagnosed with brain death
Authors: Bayrakçı Sinem , Eygi Elif
Published: February 2025

Aims: Early and rapid detection of brain death in intensive care units is important for organ transplantation. This study aimed to evaluate cases diagnosed with brain death.
Methods: The retrospective study was conducted by examining the patients diagnosed with brain death in intensive care units of the city hospital between 06.10.2023 and 01.09.2024. Demographic characteristics of the cases, hospitalization diagnoses, clinics where they received treatment, the time from admission to intensive care and the beginning of clinical suspicion of brain death until the report was prepared, additional tests applied, family organ donation rate, donor rate, and the time from the diagnosis of brain death to cardiac arrest in non-donor cases were recorded.
Results: 33 patients were diagnosed with brain death. The mean age of the cases was 52.1 and 51.6% of them were male (n=17). 57.6% of the cases had no known comorbid diseases (n=19). The intensive care units where the cases were hospitalized were 36.4% anesthesia (n=12), 36.4% neurosurgery(n=12). The hospitalization diagnosis of the cases was intracranial hemorrhage in 30.4% (n=10), cerebral infarction in 30.4%(n=10). Digital Subtraction Angiography was used in 70% (n=23) for additional supporting tests. Organ donation was made by the family in 12.1% of the cases(n=4), and organs were transplanted in 9% of these cases(n=3). The average time from admission to diagnosis of brain death was 6.66 days. The average time from follow-up of patients thought to have brain death to diagnosis of brain death was 2.03 days. The average time from diagnosis of brain death to cardiac arrest was 31.85 hours (
Conclusion: It is very important to diagnose brain death in order to increase the number of organ transplants from cadavers. In patients who may be potential donors, brain death should be determined quickly, and rapid action should be taken after diagnosis and unnecessary loss of time should be avoided.
Can platelet and leukocyte counts guide the early prediction of neonatal sepsis?
Authors: Toprak Şule , Albayrak Meryem , Aliefendioğlu Didem
Published: February 2025

Aims: Early recognition of neonatal sepsis, which is an important cause of neonatal mortality and morbidity, contributes positively to clinical outcomes. Although culture methods are the gold standard for the diagnosis, they take time and can delay critical treatment decisions. Therefore, there is a need for validation of easily accessible, cost-effective practical approaches in the diagnosis of neonatal sepsis. In our study, we aimed to evaluate the leukocyte and platelet counts as diagnostic markers in early neonatal sepsis.
Methods: In our prospective study, the contribution of platelet and leukocyte counts to the diagnostic accuracy of two groups of patients diagnosed with sepsis (group I) and excluded sepsis (group II) in the neonatal intensive care unit were evaluated on days 1, 3, 5 and 7.
Results: A significant difference was found in the group diagnosed with sepsis in terms of low platelet count and platelet reduction rates. The specificity and sensitivity of thrombocytopenia in the diagnosis of sepsis was 88.8% and 81.3%, respectively. In addition, the presence of thrombocytopenia in the early period was informative about the unfavorable prognosis.
Conclusion: We think that thrombocytopenia can be used as a screening test for early diagnosis of sepsis.
The importance of acidic microenvironment in urothelial carcinomas of the bladder: relationship with carbonic anhydrase IX expression and prognostic factors
Authors: Arslan Solmaz Özgen , Ayyıldız Hakan , Oğraş Mehmet Sezai
Published: February 2025

Aims: Bladder urothelial carcinoma (BUC) is a prevalent malignancy worldwide, ranking 13th in terms of mortality. Several prognostic factors affecting survival have been identified, including histologic grade, invasion of the muscularis propria, tumor diameter, and lymphovascular invasion. However, new markers that will be helpful in diagnosis, treatment and prognosis are still needed. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that aids in adaptation to acidosis induced by hypoxia and plays a role in cancer progression.There are few studies on the prognostic impact of CA IX on BUCs. This study aimed to investigate whether CA IX is a promising diagnostic and prognostic biomarker in BUC.
Methods: A retrospective analysis was conducted on 117 cases diagnosed with BUC whithout muscularis propria invasion between September 1995 and January 2023. Transurethral resection specimens were examined histological grade, lymphovascular invasion, tumor diameter by a single pathologist. CAIX was performed by immunohistochemical method.
Results: Among the 117 patients included in the study, 61 had low-grade tumors, while the remaining 56 had high-grade tumors. CA IX expression exhibited a significant positive correlation with histological grade (p < 0.01), lymphovascular invasion (p < 0.01). and tumor diameter (p < 0.01). Low CA IX staining was observed in three normal tissues and ıt was found to be a biomarker in the distinction between malignant and benign cases.
Conclusion: CA IX expression is associated with poor prognosis in BUCs as in some other tumors. Evaluation of CA IX staining may be important for patient follow-up and treatment strategies. Adding carbonic anhydrase enzyme inhibitors to chemotherapy regimens could potentially create new treatment options.
Etiologic evaluation of male patients diagnosed with anemia in the first consultation of the hematology department
Authors: Uzun Arzu , Kuku İrfan , Kaya Emin , Erkurt Mehmet Ali
Published: February 2025

Aims: Anemia is a decrease in hemoglobin (Hb) levels below the normal values determined by gender. Since anemia is a
laboratory finding, its etiology must be investigated. The present study aimed to investigate the etiologic spectrum of male
patients diagnosed with anemia in the first consultation of a tertiary hospital hematology department.
Methods: This study was conducted with male patients who were consulted at İnönü University, Turgut Özal Medical Center,
adult hematology department between the dates of 2010-2015. Adult male patients aged 18 years and older, who were diagnosed with anemia in the first consultation were included in the study. Hb levels under 13 g/dl in the complete blood count were accepted as anemia criteria. The study was carried out retrospectively by examining the records of the hospital automation system.
Results: The records of a total number of 7840 adult male patients were examined and 473 (6%) of them were found to have
anemia when they first consulted in the hematology department. Iron deficiency was the most common etiological cause with the number of 97 patients (20.5%). In the first consultation; malign diseases were found in 50.3% (238), and benign diseases were found in 49.7% (235) of the patients, as the etiologic causes of the anemia. Multiple myeloma (MM) was found to be the most common malignant disease with a rate of 26.5% (63 patients), and isolated iron deficiency was found to be the most common benign disease with a rate of 41.3 % (97 patients); among the etiologic factors or anemia.
Conclusion: In our study, malignant diseases were detected as the etiological cause in more than half of the adult male patients with anemia in their first consultation. We think that it is important to keep this situation in mind in the etiology of anemias, especially considering the profile of patients referred to tertiary hospitals.
Pituitary extramedullary plasmacytoma without any systemic involvement: a rare case report
Authors: Çiftciler Rafiye , Karabağlı Pınar , Şahinoğlu Mert , Karabağlı Hakan
Published: February 2025

Extramedullary plasmacytoma (EMP) is a rare plasma cell disorder of the soft tissue without systemic involvement like multiple myeloma (MM). It develops outside of the bone marrow. It happens seldom for a plasma cell neoplasm to manifest as an intracranial or cranial tumor, and it is much less common for it to resemble a pituitary adenoma. In patients with sellar area plasmacytomas, headaches, cranial nerve deficits, visual abnormalities, bloody nasal discharge, and discomfort in the eyes and craniofacial regions are common presentations. A biopsy is required to make the diagnosis. For parasellar plasmacytomas to be successfully managed, an accurate diagnosis is essential. Overall, patient survival is very good, although it might be lowered if they go on to develop overt MM. If there is no known history of MM, it is advised to do a thorough workup to identify any underlying MM or to closely monitor any MM development in the future. In this study, we aimed to report a rare case who presented with loss of vision without systemic involvement of MM and whose pituitary biopsy was a plasmacytoma.
Comprehensive management of concurrent chronic lymphocytic leukemia (CLL) and evans syndrome: combinating rituximab, venetoclax and eltrombopag
Authors: Ünal Serkan
Published: February 2025

Chronic Lymphocytic Leukemia (CLL) and Evans Syndrome represent complex hematologic disorders characterized by distinct yet interconnected pathophysiologies. This case report explores the diagnostic and therapeutic intricacies of managing concurrent CLL and Evans Syndrome in a 59-year-old male patient presenting with fatigue and petechiae. Laboratory findings revealed severe hematologic derangements indicative of advanced CLL and autoimmune hemolytic anemia (AIHA). The diagnostic journey encompassed bone marrow analysis confirming CLL and Coombs positivity suggesting Evans Syndrome, with careful exclusion of immune thrombocytopenia (ITP). Initial therapeutic interventions included steroids and intravenous immunoglobulin (IVIG) for AIHA, alongside eltrombopag for persistent thrombocytopenia. Subsequently, rituximab and venetoclax were initiated for CLL, leading to complete remission. The successful outcome underscores the importance of an integrated therapeutic approach in managing concurrent CLL and Evans Syndrome, offering insights for future clinical management of complex hematologic disorders.
La teleducación como sistema
Authors: Contreras-Budge Eduardo
Published: February 2025

No abstract available.ECA Estudios Centroamericanos, Vol. 32, No. 346, 1977: 541-560.
Carta a Ignacio Ellacuría
Authors: Laín Entralgo Pedro
Published: February 2025

No abstract available.ECA Estudios Centroamericanos, Vol. 32, No. 346, 1977: 609-610.
PENGEMBANGAN MODEL SISTEM INFORMASI PENERIMAAN PESERTA DIDIK BARU DI SMK KEBANGSAAN MENGGUNAKAN METODE WATERFAL
Authors: Angga Tyas Dwi , Ayumi Vina
Published: February 2025

Proses penerimaan peserta didik baru (PPDB) yang selama ini dilakukan secara manual dengan menggunakan formulir kertas memiliki berbagai kelemahan, seperti kurang efisien, rawan kesalahan pencatatan, dan sulitnya pengelolaan data dalam jumlah besar. Untuk mengatasi masalah tersebut, penelitian ini bertujuan menggantikan sistem manual tersebut dengan sistem informasi PPDB berbasis web yang dirancang sesuai kebutuhan sekolah menggunakan metode pengumpulan data dan model Waterfall. Pengembangan sistem ini mencakup tahapan analisis kebutuhan pengguna dan fungsional sistem, perancangan, implementasi, serta pengujian. Fokus penelitian adalah permasalahan PPDB di SMK Kebangsaan, Jurang Manggu Timur, Kec. Pondok Aren, Kota Tangerang Selatan, yang dilaksanakan pada periode Oktober 2023 hingga Oktober 2024. Hasil penelitian ini menghasilkan sistem yang memungkinkan calon siswa baru untuk mengisi formulir pendaftaran, mencetak formulir dalam format .pdf, melihat hasil pendaftaran, dan mengirimkan bukti pendaftaran sebagai tanda diterima. Di sisi lain, administrator dapat mengelola berbagai fungsi, seperti menambah, mengedit, dan menghapus halaman PPDB, memproses data pendaftar, menerima atau menolak status pendaftaran, membuat pengumuman hasil PPDB, serta mengelola halaman situs web untuk pengunjung.
PENERAPAN FP-GROWTH UNTUK ANALISIS POLA PEMBELIAN PRODUK SKINCARE
Authors: Khoirunisa Pitria , Martanto Martanto , Dikananda Arif Rinaldi , Rohman Dede
Published: February 2025

Kemajuan teknologi informasi dan persaingan di industri kecantikan menghasilkan data transaksi yang besar. Algoritma FP-Growth dipilih dalam penelitian ini karena efisiensinya dalam menganalisis data besar tanpa perlu menghasilkan kandidat itemset seperti algoritma Apriori. Data ini, jika dianalisis dengan tepat, dapat memberikan wawasan yang berguna untuk memperbaiki strategi pemasaran, meningkatkan efisiensi operasional, dan meningkatkan kepuasan pelanggan. CV Leika Skincare belum memiliki panduan dalam memanfaatkan data transaksi secara optimal. Penelitian ini bertujuan untuk mengidentifikasi pola pembelian produk skincare menggunakan data transaksi penjualan dari Januari hingga Juni 2024, terdiri dari 25.818 entri data dan 22 atribut. Data dalam industri kecantikan sangat penting karena memberikan wawasan terkait perilaku pelanggan, preferensi produk, dan kebutuhan pasar, sehingga membantu perusahaan seperti CV Leika Skincare dalam merancang kampanye pemasaran yang relevan dan berbasis data. Dengan metode FP-Growth, bagian dari pendekatan Knowledge Discovery in Databases (KDD), serta bantuan perangkat lunak Rapid Miner, ditemukan 10 aturan asosiasi yang signifikan. Hasil penelitian ini memberikan wawasan strategis untuk promosi bundling produk, rekomendasi produk, dan manajemen stok yang lebih baik. Penelitian ini menunjukkan pentingnya pemanfaatan data secara strategis dalam meningkatkan daya saing di industri kecantikan.
ANALISIS PROYEK LAYANAN PENGADAAN SECARA ELEKTRONIK (LPSE) PROVINSI LAMPUNG
Authors: Antika Berli Mega , Yusuf Ridwan
Published: February 2025

Layanan Pengadaan Secara Elektronik (LPSE) adalah salah satu inisiatif strategis yang dirancang untuk mengatur proses pengadaan barang dan jasa secara digital sesuai dengan prinsip-prinsip e-Goverment. LPSE dibangun untuk mendukung pengadaan investasi dari berbagai instansi pihak pemerintah, termasuk angkatan bersenjata, untuk memenuhi kebutuhan operasional melalui sebuah platform online. Penelitian ini bertujuan untuk mengklasifikasikan data proyek dari CV Raja Artha tahun 2020-2024. Metode yang digunakan dalam studi ini adalah KNN (K-Nearest Neighbors). Tujuan utama dari penelitian ini adalah untuk mengelompokkan data proyek, mengevaluasi kinerja model KNN, dan menemukan nilai parameter k yang terbaik guna meningkatkan kinerja model. Dari analisis yang telah dilakukan dengan metode KNN, dapat disimpulkan bahwa performa model KNN menghasilkan akurasi tertinggi pada k = 1, dengan akurasi sekitar 0.71 (71%), sementara akurasi tetap stabil pada k = 6 hingga k = 10, dengan nilai sekitar 0.64 (64%) dan nilai akurasi terendah pada k = 3 hingga k = 5, dengan mencapai 0.50 (50%). Nilai k yang menghasilkan akurasi tertinggi atau paling optimal adalah k = 1. Dengan demikian, hasil dari analisis menunjukkan bahwa model berhasil mengklasifikasikan sebagian besar data proyek dengan baik
PERANCANGAN SISTEM INFORMASI MANAJEMEN PERPUSTAKAAN MENGGUNAKAN METODE USER CENTERED BERBASIS WEB
Authors: Khoiriyah Andin Nur , Ikhwan Ali
Published: February 2025

Tujuan dari penelitian ini adalah untuk menggunakan pendekatan User-centred Design (UCD) untuk mengembangkan dan menyebarkan Sistem Informasi Manajemen Perpustakaan berbasis web di SMP Negeri 3 Rantau Utara. Sistem ini dimaksudkan untuk mengefisienkan administrasi perpustakaan, meningkatkan produktivitas, dan meningkatkan mutu layanan yang ditawarkan kepada pengguna—khususnya, siswa dan personel sekolah. Memahami konteks penggunaan, mengidentifikasi tuntutan pengguna, merancang solusi desain, dan menilai persyaratan adalah semua langkah dalam proses UCD yang termasuk dalam proses pengembangan sistem. Hasil dari penelitian ini adalah sistem informasi perpustakaan dengan sejumlah fitur utama, seperti layar login, daftar transaksi, daftar buku yang dipinjam dan dikembalikan, transaksi denda, daftar anggota, daftar buku, daftar kategori buku, daftar buku di rak, laporan transaksi pinjaman, dan daftar pengembalian buku. Dengan penekanan pada tuntutan pengguna dan kenyamanan penggunaan, setiap fitur dibuat untuk membantu kegiatan operasional perpustakaan. Kemampuan sistem untuk memenuhi kebutuhan pengguna dan meningkatkan efisiensi administrasi perpustakaan ditunjukkan melalui pengujian dan evaluasi. Selain itu, teknologi ini mempercepat dan mempermudah perolehan informasi perpustakaan dan memungkinkan pustakawan mengelola dan mengawasi perpustakaan dengan lebih baik. Oleh karena itu, penerapan sistem informasi administrasi perpustakaan berbasis web ini diharapkan dapat meningkatkan mutu layanan perpustakaan di SMP Negeri 3 Rantau Utara secara signifikan.
IMPLEMENTASI KURIKULUM DALAM GAME EDUKASI DENGAN MEKANIKA BERBASIS TUGAS
Authors: Sabillah Muh. Agung , Yusuf Mukarramah , Warni Elly
Published: February 2025

Mekanika adalah semua hal yang dapat dilakukan atau dikuasai oleh pemain dalam game, mengcakup tindakan, perilaku, dan mekanisme. Dalam mengembangkan sebuah game edukasi, desain mekanika game adalah tantangan yang harus dipecahkan. Game edukasi harus dapat menerjemahkan kurikulum menjadi mekanika game. Penelitian ini mengembangkan game edukasi dengan mekanika berbasis tugas untuk mencapai tujuan kurikulum. Studi kasus pada penelitian ini adalah mata pelajaran Sejarah. Pembelajaran sejarah memainkan peran penting dalam membentuk karakter dan identitas bangsa. Namun metode pengajaran konvensional sering kali dianggap monoton dan kurang menarik, sehingga menurunkan minat siswa terhadap pelajaran Sejarah. Hasil penelitian menunjukkan bahwa penggunaan game berbasis mekanika tugas mampu meningkatkan pemahaman siswa terhadap materi sejarah. Dengan kondisi awal hanya 35% soal evaluasi materi Sejarah dapat dijawab dengan benar oleh mayoritas siswa, setelah memainkan game, sebanyak 80% soal dapat dijawab dengan benar oleh mayoritas siswa
IMPLEMENTASI METODE K-MEANS UNTUK KLASTERISASI VARIETAS PARPIKA DENGAN MENGGUNAKAN TEKNIK PENGOLAHAN CITRA DIGITAL
Authors: Ilmawan Fachrul , Ramadhanu Agung
Published: February 2025

Dengan menggunakan kombinasi segmentasi objek, ekstraksi bentuk, dan ekstraksi tekstur, penelitian ini bertujuan untuk melakukan klasterisasi pada varietas paprika melalui penggunaan K-Means Clustering dan Gray-Level Co-Occurrence Matrix (GLCM).  Segmentasi objek dilakukan menggunakan algoritma K-Means Clustering untuk membedakan objek dari latar belakangnya. Selanjutnya, proses ekstraksi tekstur dan bentuk dilakukan menggunakan Matriks Co-Occurrence Level Gray (GLCM) untuk membedakan jenis varietas paprika. Hasil kalsterisasi dicapai melalui penggunaan aplikasi matlab, yang mencakup import data, konversi RBG ke L*a*b, segmentasi objek dengan latar belakang menggunakan K-Means Clustering, dan kemudian menggunakan metode Gray-Level Co-Occurrence Matrix (GLCM) untuk ekstraksi bentuk dan tekstur. Hasil penelitian tentang klasterisasi varietas paprika juga menunjukkan bahwa proses itu berhasil. Model berhasil mengidentifikasi setiap sampel gambar dengan akurat seratus persen dengan menggunakan sampel delapan gambar paprika merah dan hijau. Penggunaan algoritma clusteriang K-means dan Matriks Co-Occurrence Level Gray (GLCM) menunjukkan hasil yang sangat baik; ini membuktikan efektivitasnya dalam melakukan klasterisasi pada varietas paprika.
MEDIDAS SOCIOEDUCATIVAS E A RESPOSTA DO ESTADO AOS JOVENS INFRATORES NO BRASIL
Authors: Gass Eduardo Bohn , De Moraes Dilcionir , Feltraco Tiago Daniel , De Oliveira Fábio Ribeiro , Conegatto André Xouquel
Published: February 2025

This article’s primary purpose is to analyze the effect of socio-educational measures in Brazil, emphasizing the role that the State and the family play in the training and reintegration of young offenders. The research explores relevant issues, such as overcrowding in socio-educational institutions and its adverse impact on the recovery of young people, in addition to investigating the effectiveness of these measures in reducing criminal recidivism and promoting adequate reintegration into society. With a deductive methodological approach and a bibliographical review, the study examines related doctrines and legislation, with special attention to the Statute of Children and Adolescents, to then deduce significant results and implications of the socio-educational practices implemented.
Environmental Impacts of Different Types of Ceramic Tiles using Life Cycle Assessment (LCA): A Case Study of a Ceramic Tiles Company in Czech Republic
Authors: BEDNÁŘOVÁ Nikola , ŠIMON Michal , HOŘEJŠÍ Petr
Published: February 2025

This study examines the environmental impacts of ceramic tiles using the Life Cycle Assessment (LCA) methodology, which evaluates the carbon footprint of production processes. The study addresses a gap in the literature by assessing how different tile sizes impact environmental performance, which is crucial for improving sustainability in ceramic manufacturing. The LCA was conducted in a gate-to-gate model according to ISO standards, covering processes such as raw material extraction, mixing, grinding, pressing, glazing, firing, and packaging. The functional unit was 1 m² of tile, and two tile sizes, 60×60 cm and 60×120 cm, were compared to understand how size influences ecological impact.

The primary findings reveal that the carbon footprint of the 60×120 cm tile (3.63 kg CO₂eq/m²) is not double that of the smaller 60×60 cm tile (2.58 kg CO₂eq/m²), but only 27% higher. This difference suggests that larger tiles allow for more efficient material and energy use, resulting in a lower relative environmental impact. The analysis also identifies mixing and grinding, pressing, and firing as the most energy-intensive processes, with grinding contributing 32% to the carbon footprint of the smaller tile and 27% for the larger one. These insights highlight opportunities for process optimization and energy reduction.

Additionally, the study explores the use of recycled materials in the production of larger tiles, which can lower the demand for new raw materials and reduce the overall carbon footprint. The findings confirm a non-linear relationship between tile size and carbon footprint, with larger formats resulting in a lower environmental burden. This underscores the importance of optimizing production processes for larger tiles, which are often more valuable in the market.

The research demonstrates the importance of LCA in developing sustainable manufacturing practices. Moving forward, standardizing LCA methodologies within the ceramic industry will enable better comparisons and evaluations of production techniques and their environmental impacts. These advancements are critical for achieving long-term sustainability and minimizing environmental harm in the sector.
Best Practices for Energy Management in the Steel Industry Facing Decarbonisation
Authors: SKRZYNIARZ Magdalena , MOREL Slawomir
Published: February 2025

Decarbonising steel sector constitutes a global challenge in the context of regulatory constraints aimed at reducing carbon emissions or even achieving carbon neutrality by the end of 2050 Many solutions are currently being implemented and tested in the industry, but the problem of achieving the carbon target remains complex and difficult. This paper presents the best practices focused on energy management in the steel industry in the face of decarbonisation. Among the potential directions for decarbonising the steel industry, the following are mentioned in particular: using green hydrogen instead of coal, renewable energy sources, and the energy management of post-process gases. It is likely that no single option or technology will be the best or only solution, but a combination of breakthrough technologies should be developed and implemented to address the increasing energy consumption and CO2 emissions in the iron and steel industry.
The Process of Decarbonization and Emission Reduction in Poland and Spain in 2014-2022 compared to other EU countries
Authors: SKRODZKA Wioletta
Published: February 2025

Objectives: The main objective of the article is to analyze the pace of decarbonization and reduction of air pollutant emissions in Poland and Spain. The directions and dynamics of changes in the structure of available gross electricity in Poland and Spain in the light of the EU climate goals were also examined. Expected Results: The study was based on data from Eurostat for the years 2014-2022. The methodology uses taxonomic measures of structure variability. The analysis focuses on Poland and Spain, countries traditionally based on fossil fuels, but significantly different in the structure of electricity production. The research showed that Poland and Spain implement EU climate policy in different ways. It was shown that the level of emissions, as well as the structure of available gross energy in Poland and Spain in the analyzed period, were diverse. However, the intensity of the pace of change in the analyzed structures was relatively low in both countries, and the increase in diversification results in a significant increase in the share of renewable and low-emission sources. The limitation of the research is the availability of data. The originality of the study lies in filling research gaps in the analysis of the degree of air pollution reduction against the background of changes in the concentration of the gross electricity production structure of EU countries, with particular emphasis on Poland and Spain. Implications: The research results can be used in shaping the goals of climate and energy policies of countries with diversified electricity production structures.