bluuebunny/crossref_metadata_2025 huggingface dataset:
DIREITO E ECONOMIA: ACORDO DE NÃO PERSECUÇÃO PENAL-ANPP COMO INSTRUMENTO CONSEQUENCIALISTA DE GESTÃO PROCESSUAL EM ESTÍMULO À SEGURANÇA PÚBLICA
Authors: Oliveira Emerson Ademir Borges de , Garcia Lidiane da Cruz , Ryndack Jaqueline Maria
Published: December 2024

O presente artigo direciona-se à temática do Direito e Economia no âmbito da segurança pública. O estudo objetiva a análise do instituto do ANPP - Acordo de Não Persecução Penal como meio para favorecer uma gestão processual mais eficiente e eficaz para diminuição do número de processos em tramitação e gerar melhores resultados para a evitação do cometimento de crimes. Foi utilizado método bibliográfico a partir de apanhado analítico em livros e periódicos especializados da Ciência Jurídica, em raciocínio lógico-dedutivo. O problema fundamental está na análise da dogmática normativa e na averiguação teórica da eficácia e da eficiência do instituto pelo referencial da Análise Econômica e Social do Direito por tratar-se de uma previsão nova da legislação pátria. O intuito é trazer o estudo do instituto especialmente à luz do consequencialismo versado pelo movimento de Law and Economics. Deste modo, dentre alguns dos aspectos conclusivos, chega-se à consideração de que o instituto é deveras importante ao proporcionar alternativa mais célere que a tramitação processual. Assim, potencialmente, gera eficiência econômica e eficácia processual por resultar em desfecho mais democrático, construído pela autonomia da vontade, por ser o custo do crime um artifício pedagógico e que beneficia a sociedade como um todo quanto à demanda por segurança pública.
SEGURANÇA E PREVENÇÃO NO VAZAMENTO DE DADOS NO CDC E NA LGPD
Authors: Morishita Ricardo , Lourenço Nyvea
Published: December 2024

O trabalho analisa as mudanças e adaptações na rotina das pessoas introduzidas pelos meios digitais e outros fatores no mundo globalizado. Após a inserção dos dados pessoais para utilização desses meios virtuais, as pessoas, de certa maneira, perdem o controle sobre esses dados que ficam armazenados com terceiros. Importante ponto é: qual a segurança que o usuário/consumidor tem que esses dados não serão vazados e/ou utilizados de forma indevida? Nesse contexto, o trabalho objetiva trazer reflexões sobre medidas de segurança e prevenção no vazamento de dados no Código de Defesa do Consumidor - CDC e na Lei Geral de Proteção de Dados - LGPD, em especial, o Relatório de Impacto à Proteção de Dados Pessoais - RIPD, que é visto como uma forma de salvaguardar ou mitigar o risco no vazamento dos dados. O referido relatório ainda não foi regulamentado pela Autoridade Nacional de Proteção de Dados; autoridade brasileira responsável por implementar, fiscalizar e zelar pelo cumprimento da LGPD. A questão é: o RIPD deve ser obrigatório ou não para todos os Controladores? Na metodologia, o desenvolvimento do tema será utilizada a técnica de pesquisa documental e bibliográfica. Além de bibliografia utilizar-se-á legislação, artigos especializados, seminário e entendimentos jurisprudenciais.
PRINCÍPIO PRÓ MISERO E SUA APLICAÇÃO PARA CONCRETIZAÇÃO DOS DIREITOS DO TRABALHADOR RURAL
Authors: Mingati Luiz Fernando
Published: December 2024

O presente artigo discorre sobre as garantias e os direitos concedidos ao trabalhador rural pela Constituição da República Federativa do Brasil de 1988, que o equiparou, de forma isonômica, ao trabalhador urbano. Ele também expõe a dificuldade que os rurícolas possuem na concretização de seus direitos, em razão da informalidade que exercem o trabalho e da sua hipossuficiência informacional e econômica. Além disso, o estudo disserta acerca dos princípios como meios legais justificadores da busca pelo atendimento social da legislação e, ainda, da conceituação e da aplicação concreta do princípio pró misero em casos que envolvem o profissional rural. Trata-se, portanto, de um instrumento necessário para que os direitos conferidos ao segurado especial possam ser garantidos e efetivados, concedendo-lhe dignidade a sua pessoa. Por fim, este artigo utilizou-se de diversas revisões bibliográficas e jurisprudencial.
LITIGÂNCIA DE MÁ FÉ E O ACESSO À JUSTIÇA
Authors: Rimoli Fabiola , Aragão Vanessa Alves
Published: December 2024

A proteção da prática advocatícia e a garantia do acesso à justiça devem ser preservadas para vedar abusos, em regra, de demandadas na litigância predatória, preservando assim, a prestação jurisdicional, especialmente na era moderna com o incremento do acesso à internet e realização de contratos eletrônicos. Exigindo assim, a modernização do Direito com o surgimento e a necessidade da regulação da área digital, que deverá se fazer acompanhar não só de conhecimentos técnicos, como também da boa-fé processual, principalmente dos advogados, sob pena de sofrerem com maior rigor para realizarem a comprovação dos requisitos da petição inicial, como já estudado no Tema de n°1198 do STJ.
How @paparazikuansing Popularizes The Cultural Tradition of Pacu Jalur Kuantan Singingi Riau ?
Authors: Agwenda Mezzi , Yasir  , Yesicha Chelsy
Published: December 2024

This research aims to analyze the content marketing strategy of the pacu jalur culturaltradition through the TikTok platform, focusing on the @paparazikuansing account. Through aqualitative and case study approach, this research explores how the @paparazikuansing accountcreates, distributes, and amplifies content related to the pacu jalur cultural tradition.The main findings show that the use of TikTok as a promotional medium is able to increase publicawareness and understanding of the pacu jalur cultural tradition. The creative content presentedmanaged to attract the attention of users from various circles, both at home and abroad. The highinteraction between the @paparazikuansing account and its followers is also an important factor inbuilding engagement and emotional connections with the audience.The implication of this research is the need to continue to pay attention to and optimize user responsesand interactions as the key to success in building engagement with audiences. The proposedrecommendations include the need for research and analysis of audience characteristics, collaborationwith influencers, and other TikTok users to expand the reach of content. It is hoped that the results ofthis study can contribute to the development of content marketing strategies for the pacu jalur culturaltradition through social media, as well as become a reference for further research in the field of contentmarketing and traditional cultural development. In conclusion, collaboration between the@paparazikuansing account, followers, and other related parties can strengthen the promotion andpreservation of the pacu jalur cultural tradition through digital platforms.
Проєктування чотириколісної мобільної роботизованої платформи для задач з дезактивації
Authors:   Technical University of Košice, Pilát Patrik , Semjon Ján ,   Technical University of Košice, Varga Jozef ,   Technical University of Košice
Published: December 2024

This article presents the design of a four-wheeled mobile platform for a special service robot, intended to clean contaminated areas in the hot gas chamber of a nuclear power plant reactor. The reactor, KS-150, was part of Czechoslovakia's early nuclear energy development and encountered two significant accidents, leading to its decommissioning. Decommissioning efforts now require the removal of contaminated deposits from the reactor's hot gas chamber, a challenging task due to restricted access and radiation levels. The proposed solution involves using a mobile service robot to replace human workers in hazardous conditions, ensuring safety and efficiency. Five chassis designs were evaluated based on criteria such as energy consumption, structural com-plexity, contamination risk, and maneuverability. The selected design is a four-wheeled chassis with two steered wheels. The robot's mobility subsystem is a fundamental part of the overall design, supporting various attachments, including a robotic arm, a front brush, and a detachable container for waste removal. The design offers a robust and efficient solution for cleaning contaminated environments, contributing to safer decommissioning processes in nuclear facilities.
Застосування безпілотних літальних апаратів для виконання радіаційного моніторингу
Authors:   Національний університет «Чернігівська політехніка», Крячок Сергій
Published: December 2024

Огляд існуючих систем візуалізації радіаційного випромінювання показав, що системи комптонівської візуалізації та з рухливими детекторами спроможні працювати у віддаленому радіаційному полі та мають невелику вагу, а тому найбільш придатні для застосування на платформах БПЛА. У результаті аналізу встановлено, що наразі системи комптонівської візуалізації ефективні лише для виявлення джерел радіаційного випромінювання в тісному міському середовищі та приміщеннях, а системи з рухливими детекторами дозволяють виконувати гамма-моніторинг повному обсязі.
Джерела даних супутникового радіолокаційного знімання.
Authors:   Івано-Франківський національний технічний університет нафти і газу, Кухтар Денис
Published: December 2024

Стаття є викладом здобутих знань щодо використання різних джерел даних супутникового радіолокаційного зні-мання для моніторингу природних та техногенних геодинамічних явищ. Розглянуто ресурси для завантаження, візуалізації та попереднього опрацювання радіолокаційних даних. Наведено перелік супутникових місій, дані яких представлено у вільному доступі на сайті активного архівного центру Alaska Satellite Facility. Виконано огляд комерційних радіолокаційних місій та особливості результатів їхнього знімання. Розглянуто можливості розширення кола джерел радарних знімків, які можуть бути використані для науково-дослідних цілей, у межах програми Європейської космічної агенції «Місії третьої сто-рони». Викладена інформація буде корисною для науковців, науково-педагогічних та педагогічних працівників, які викорис-товують дані дистанційного зондування, зокрема радіолокаційні знімки, для освітніх та наукових потреб.
Reforming Legal Decision-Making: A Study of Hindsight Bias on Judicial Impartiality
Authors: Zahra Salma , Azizan Akmal , Sophia Sally , Perai Nurajam
Published: December 2024

Legal decision-making is heavily influenced by cognitive processes like memory and judgment, which are vulnerable to biases such as false autobiographical memories, hindsight bias, and pretrial publicity. These flaws can lead to wrongful convictions, biased negligence assessments, and compromised impartiality, undermining legal fairness. This study examines these cognitive vulnerabilities, analyzing their mechanisms and proposing strategies to reduce their impact. A literature review of empirical research from 2018 to 2023 integrates findings from psychology, neuroscience, and law. The study highlights how these biases affect legal outcomes and suggests practical solutions like simplified judge instructions, structured interrogation protocols, and bias awareness training. The research uses Cognitive Load Theory, aiming to enhance the integrity of legal processes and provide evidence-based recommendations to improve the fairness and accuracy of legal decisions.
história da filosofia como coisa da filosofia
Authors: Fernandes Marcos Aurélio
Published: December 2024

Este ensaio pretende pôr em discussão questões que concernem à história da filosofia. Tais questões são: o que é filosofia? Qual a sua “coisa”? A “coisa” da filosofia é histórica e/ou é história? A história da filosofia diz respeito essencialmente a esta “coisa”? Como é a historicidade da filosofia? Quais as possibilidades e os limites de uma historiografia filosófica? Qual o sentido de uma confrontação pensante com a história da filosofia? Filosofia é filosofar. Filosofar é uma realização de ser. É a radicalização da possibilidade de ser do pensamento. Trata-se de uma correspondência ao mistério do que se dá e se subtrai nas destinações do tempo. Filosofia é correalização cairológica da realidade. A historiografia filosófica que se empreende depende, a cada vez, em sua visão prévia, conceituação prévia e em sua posição prévia, da filosofia da história da filosofia que se tem. Os métodos do pensamento objetivo (método filológico, hermenêutica enquanto técnica e teoria da interpretação) são insuficientes para uma confrontação pensante com a história da filosofia. Esta requer uma hermenêutica originária.
Comparison of clinical profile and demography of sexually transmitted infections (STIs) among patients attending an STI clinic in the pre-coronavirus disease-2019 (COVID-19), COVID-19, and post-COVID-19 era: A retrospective data analysis
Authors: Nazar Tanya , Cindana Punithakumar , Kappan Raniya Samed , Sathyan Anagha , George Biju , Sasidharanpillai Sarita
Published: December 2024

Objectives:

The objectives of this study were to compare between the clinical profile and demography of patients with sexually transmitted infections (STIs) who attended the STI clinic of our tertiary care institution during comparable timelines in pre-coronavirus disease-2019 (COVID-19) (2018 June–2019 May) and COVID-19 (2020 June–2021 May) periods and between pre-COVID-19 and post-COVID-19 (2022 June–2023 May) periods.

Materials and Methods:

Using a pre-set pro forma, we collected data on the demography and clinical profile of patients with STIs who attended our STI clinic during comparable timelines during pre-COVID-19, COVID-19, and post-COVID-19 periods.

Results:

In comparison to the pre-COVID-19 period, a significant decline and a significant rise were noted in the total number of STI cases during the COVID-19 period and post-COVID-19 period, respectively. Compared to the pre-COVID-19 period, post-COVID-19 period witnessed an increase in the actual number of all STIs, except condylomata acuminata.

Limitations:

Data from a single center and retrospective design were the major limitations.

Conclusion:

We observed a post-COVID-19 surge in the number of STIs. The pattern of STIs in the post-pandemic era assumes importance in planning future strategies.
A Delphi Study on Digital-Based Narrative Curriculum in Art Teacher Education
Authors:   Society for Art Education of Korea, SOHN Jihyun , LEE Hyesun
Published: December 2024

This study gathers expert opinions on developing a digital-based narrative curriculum for pre-service elementary teachers. Eleven university art education experts participated in a three-round Delphi survey,reaching a consensus on 55 items related to the necessity, objectives, advantages and challenges, categories, and content elements of a digital-based narrative curriculum. The study’s findings suggest the following: First, teacher education institutions can establish new courses on digital-based narrative education or incorporate the topics and content elements proposed in this study into existing courses. Second, they should support course delivery with instructional materials, strategies, and techniques for effectively teaching digital narrative curriculum content. Third, the curriculum can encourage preservice teachers to reconstruct their knowledge and experiences narratively to shape their professional identities. Fourth, institutions can foster digital literacy through integrative, narrative-based learning experiences across multiple subjects. Fifth, they should include ethics and copyright education and address the digital divide in digital environments. Based on these results, we hope future efforts will focus on developing detailed lesson plans, introductory textbooks, and ongoing teacher training to promote practical education in this field further.
By Accumulating Research and Establishing a Theoretical System Through the Publication of 『Art Education Review』 Establishing Orthodoxy and Identity
Authors:   Society for Art Education of Korea, SIM Youngok
Published: December 2024

This study presents the 40 years of research results and future vision of 『Art Education Review』, an academic journal registered with the National Research Foundation of Korea, which has played a pivotal role in art education research in Korea in celebration of the 40th anniversary of the Korean Society of Plastic Education in 2024. A total of 1,092 research works have been published in 『Art Education Review』 since the first volume was published in 1985 until the 91st volume in 2024 (as of September 2024). The research results accumulated over these 40 years were divided into five periods, and key keywords for each period were derived to review the direction of art education at the time. And by analyzing the main achievements that have been discussed so far, we tried to establish a theoretical system of art education required by future society and establish the legitimacy and identity of art education through this. Also, by presenting a vision for the direction of art education in Korea after 10 years from a global perspective until 2035, we explored the role of art education researchers in Korea and the future direction of art education.
Exploring a Personalized Art Education Strategy for Slow Learners Focusing on Teacher Narrative Analysis
Authors:   Society for Art Education of Korea, LEE Sunhye , LEE Soojin
Published: December 2024

The purpose of this study is to explore customized art education strategies for slow learners and to suggest ways to solve their difficulties. Slow learners tend to be alienated from traditional educational methods and often experience frustration in art education due to their slow learning speed. Therefore, this study emphasized the necessity of a customized education strategy to support these students and attempted to derive an effective educational approach through teacher's narrative analysis. The study was conducted through narrative analysis for teachers with more than 10 years of art education experience, and through this, the necessity of customized art education for slow learners was confirmed in terms of 'educational inquiry method (educational strategy)' and 'environment construction method (environment creation strategy). The implications for the customized art education strategy for slow learners through the research results are as follows. First, the importance of a personalized approach is very clear. Second, the creation of an educational environment is very important. Third, technology integration is very important in modern art education. Fourth, teachers play a key role in providing customized art education to slow learners. Fifth, the importance of continuous evaluation and feedback is very large. This study re-examines the importance of art education for slow learners and emphasizes the need to create an educational environment that can maximize their potential through customized educational strategies. These findings can be used as basic data to develop various educational strategies to support slow learners in art education in the future.
A Development of Art Education Program for Implementing Education for Sustainable Development
Authors:   Society for Art Education of Korea, JEON Soohyeon
Published: December 2024

SD and ESD are more important than ever as part of global efforts to solve problems with the natural environment. In this study, art education program for implementing ESD is developed and investigated its educational effectiveness. This program goes through the process of recognizing sustainability issues, having awareness of the problem, and creatively solving problems. Through this, responsibility and action, sensitivity and empathy, love for the natural ecosystem, integrated thinking, and cooperative capabilities are developed. It is designed to be mindful and considerate of the natural environment and ecosystem. As a result of implementing the program on 26 sixth-grade students at an elementary school in Gyeonggi-do, the students were able to gain a deeper awareness of the seriousness of environmental problems and deepen their awareness of issues related to the global environment. Through this study, we will be able to contribute to SD by cultivating social responsibility and community spirit through art.
A Framework for Digital Literacy in Art Education in the Digital Transformation Era
Authors:   Society for Art Education of Korea, CHO Wonsang , LEE Jooyon
Published: December 2024

In the era of digital transformation, discussions on digital literacy are actively progressing; however, a comprehensive and systematic concept of digital literacy within art education remains limited. Addressing this gap, this study aimed to develop a digital literacy framework specifically for art education and to define the essential digital competencies needed from the perspective of art education in the digital age. This study focused on the digital literacy framework proposed by Kim et al.(2023) and analyzed it in alignment with the achievement standards outlined in the 2022 rev. Korean National Art Curriculum for elementary to high school levels. Based on this analysis, this study developed the digital literacy framework for art subject that includes 3 major domains, 6 detailed components, 13 learning elements, and 24 specific learning items. Additionally, this study provided learning activities and guiding questions for each school level to strengthen the structure of the digital literacy framework. This study was significant for proposing and providing the systematic digital literacy framework for art education that is applicable across all school levels.
The Implications of UNESCO’s AI Competency Framework for Teachers (2024) to Korean Art Education
Authors:   Society for Art Education of Korea, CHO Wonsang
Published: December 2024

As a result of the Fourth Industrial Revolution, new digital technologies, vastly different from those of the past, have emerged in society, with artificial intelligence (AI) receiving the greatest attention. Consequently, research is actively being conducted in art education to determine appropriate approaches for utilizing AI. This study focuses on the role of teachers as central figures in art education, positing that teachers' AI competencies are essential for the effective integration of AI into art education. The purpose of this study is to identify the AI competencies required for art educators, based on this perspective. To achieve this, we focused on UNESCO's (2024) 'AI Competency Framework for Teachers,' which outlines AI competencies for educators applicable to school education worldwide. This framework was reinterpreted in relation to the competencies outlined in the 2022 revised art curriculum. As a result, we identified five key AI competencies for teachers in art education: aesthetic AI competency, ethical AI competency, creative AI competency, educational AI competency, and developmental AI competency. It is hoped that this study offers insights into implementing AI in art education in ways that preserve the intrinsic value of the arts.
Art Therapy for the Psychological Well-Being of a Visual Artist Experiencing Depression : A Qualitative Case Study
Authors:   Society for Art Education of Korea, CHOI Ye-seul , HAN Kyeonga
Published: December 2024

This study explores the experience of art therapy for the psychological well-being of a visual artist experiencing depression. Participant of this study is a 37-years-old visual artist experiencing depression. Total 8 sessions of 60 minutes art therapy was conducted from July 15, 2024 to September 2, 2024. All sessions were recorded, artworks were photographed, and a in-depth interviews were conducted. From data analysis, 5 major themes and 13 sub-themes were identified, leading to the following conclusions. First, the participant explored her inner self by immersing herself in art in a different way as an artist. Second, the participant reconnected with her identity as an artist discovering the meaning of her visual language. Third, the participant integrated her identity as an artist and found meaning in life from a flexible perspective. The significant of this study lies in its detailed presentation of the process through which a visual artist experiencing depression recovers psychological well-being through art therapy.
Anti-Eczema Activity of Bacterial Red Pigment Prodigiosin: an in silico study
Authors: Gujjeti Chandrakala , K.V.N. Rajeshwari , Gurram Shyam Prasad
Published: December 2024

Eczema is a chronic inflammatory disease of the skin with itching, rashes, dryness, blisters, and scaly patches. As of now, there is no proper treatment for eczema. The drugs available so far do not respond after using for some time and result in undesirable side effects viz. permanent skin withdrawing and systemic stopping of adrenal function. To find a solution for eczema, anti-eczema activity of prodigiosin, a red bacterial pigment which was reported to show many promising potential therapeutic activities viz. anti-microbial, anti-protozoan, insecticidal, anti-parasitic, immune modulator, anticancer and antiviral activities was studies in silico, targeting different proteins involved in causing the disease.

From the results, it is clear that strong binding affinity of prodigiosin with the proteins involved in causing eczema was recorded. Hence, it can be concluded that prodigiosin, the red pigment of bacterial origin can be developed as a promising anti-eczema drug. However, further investigations are needed.
Characterization and antifungal activity of extracellular β-1,3-glucanase from Paenibacillus polymyxa AT4
Authors: Quang Hoang Tan , Tram Tran Thi Ngoc , Hien Hoang Tien , Thi Ton Nu Minh , Thi Pham Thi Diem
Published: December 2024

Beta-1,3-glucanase is a pivotal enzyme involved in controlling plant pathogens by its contribution to the hydrolytic degradation of β-glucan, one of the major constituents of the fungal cell wall. The objective of this study is to investigate the enzymatic attributes and antifungal efficacy of extracellular β-1,3-glucanase from Paenibacillus polymyxa AT4. The results show that following an 18-hour growth period of the AT4 strain the extracellular β-1,3-glucanase activity reached a maximum value of approximately 2.027 U/mL. Moreover, the optimal activity conditions for the enzyme were determined to be 40°C and 6.0 whereas thermal and pH stability ranged from 30°C to 55°C and 5.0 to 7.0, respectively.

The presence of metal ions at 5 mM such as Co2+, Mn2+ and Fe3+ significantly increased β-1,3-glucanase activity up to 118%, 129% and 141% respectively. The inhibitory effects of various compounds including ethylene diamine tetra acetic acid (EDTA), sodium dodecyl sulfate (SDS), urea and triton X-100, on β-1,3-glucanase activity were inhibited. In a controlled in vitro environment, β-1,3-glucanase applied at 0.200 U/mL had a suppressive effect on the growth of Colletotrichum spp., with inhibition levels of approximately 93% for C. scovillei HUD1 and C. fructicola HUCL5, 95% for C. scovillei HUCL1 and C. siamense HUCL3. Besides, β-1,3-glucanase from P. polymyxa AT4 demonstrated a notable ability to mitigate anthracnose development induced by Colletotrichum spp. on chilli fruits for an extended duration of up to 144 h following enzyme pretreatment at 2 U/mL.
Construction and analysis of the interactome of eugenol to identify the modular proteins and their role in cancer
Authors: Andrade Preema , Hanumanthappa Manjunatha , Prakash Nayana , Venkataramanaiah Vijayalakshmi
Published: December 2024

Cancer is a disease resulting from abnormalities in complex biological networks. Rather than a single target, many potential drugs target multiple pathways through protein modulation. This leads to the motivation to develop methods that help to predict drug interactions in complex networks accurately. Eugenol, a phenylpropanoid, is used for the study. It has been found that eugenol is a drugable molecule that is effective in treating cancer. We have executed a computational platform that combines network pharmacology and systems biology to unravel the molecular mechanisms of the complex disease cancer. The primary PPI network was retrieved using the PubChem, CTD and STITCH databases and the interactome was constructed using STRING and analyzed using the Cytoscape tool. The interactome is simplified using MCODE. MCODE reduces the interactome to densely connected regions based on its topology.

We identified RBL1, CXCL11, MVK, ELANE and FBXO11 as the top potential drug targets that may provide novel insights into drug discovery. The functional and pathway enrichment analysis of the top MCODE modules was performed using the PANTHER and DAVID databases respectively. The expression analysis of hub genes was carried out using a Kaplan-Meier plotter. These genes may serve as potential biomarkers to treat cancer.
Comparison of cultivated Cordyceps militaris and wild Ophiocordyceps sinensis using high-performance thin-layer chromatography
Authors: Kondapalli Vamsi Krishna , Malaviya Alok
Published: December 2024

Cordyceps, a fungus from the ‘Clavicipitaceae’ family, has long been utilised in traditional Chinese medicine as a rare and prized mushroom. Among 750 known species, two noteworthy species within the genus are Ophiocordyceps sinensis and Cordyceps militaris. Among the active components generated by this genus, cordycepin and adenosine are particularly significant and exhibit various pharmacological properties. To evaluate and compare the concentrations of cordycepin and adenosine, high-performance thin-layer chromatography profiling was employed on lab-grown C. militaris and wild O. sinensis. Water and ethanol were utilised to extract the nucleosides.

The concentrations of these nucleosides from different samples were calculated by using Rf (Retention factor) values of both cordycepin and adenosine standards. Interestingly, the fruiting bodies of C. militaris obtained through solid-state fermentation exhibited a higher cordycepin content (12.3 mg/g) compared to biomass obtained via liquid static culture. In the case of O. sinensis, cordycepin was found to be absent, with only adenosine (approximately 0.81 mg/g) being quantified.
Cyanobacterial consortia as biostimulant for germination of Zea mays seeds
Authors: Behera Priyanka , Mahalik Shubhashree
Published: December 2024

Cyanobacterial extracts are known to be rich in several plant growth promoting metabolites as well as phytohormones. Indole 3 acetic acid is one of the phytohormones that are known to be promoting seed germination. On the basis of the ability of three cyanobacterial species Westiellopsis sp. TPR-29, Hapalosiphon sp. Ryu2-7DN_D3 and Chlorogloeopsis fritschii PCC 6912 to produce IAA, their cell free supernatant were tested for induction of germination in Zea mays (Maize) seeds. The seeds were treated with cell free extracts of 15 days old cyanobacterial cultures for 24 and 48 hours.
Unveiling the therapeutic potential of nano based drug delivery methods for plumbagin and its future implications
Authors: Natarajan Kiruthiga , Chandrasekaran Rajkuberan , Sangilimuthu Alagar Yadav
Published: December 2024

The quinine derivative plumbagin (PLB), primarily sourced from the Plumbago zeylanica Linn. plant, exhibits a diverse array of pharmacological endeavors including antifungal, anti-inflammatory, antibacterial, anticancer, neuroprotective, antioxidant and hypolipidemic effects. Despite its promising therapeutic potential, plumbagin has been hindered by its inherent limitations such as poor bioavailability, instability and limited solubility in water. Over the past few decades, considerable efforts have been directed toward overcoming these challenges by developing advanced delivery platforms. These platforms aim to enhance the efficacy and applicability of plumbagin in various medical contexts. This comprehensive review aims to consolidate the extensive body of research elucidating the biopharmaceutical properties of plumbagin. It provides a detailed examination of the scientific evidence supporting its multifaceted therapeutic benefits while also shedding light on the obstacles hindering its clinical utility.

Furthermore, the review delves into the innovative strategies devised to address the issues of solubility and bioavailability associated with plumbagin. In addition to discussing the current state of research on plumbagin, this study offers insights into the ongoing efforts to innovate drug delivery systems tailored specifically for plumbagin. Drawing from a wide spectrum of perspectives, it explores novel approaches and technologies that hold promise in optimizing the pharmacokinetic profile and therapeutic outcomes of plumbagin-based treatments. Delving deeply into the therapeutic advantages of plumbagin while tackling its inherent obstacles, this review artfully weaves together current insights and future trends to pave the way for innovative and effective PLB-centered therapies.
ИНТЕРФЕРЕНЦИИ НЕКОТОРЫХ ПОЛИАТОМНЫХ ИОНОВ ПРИ ОПРЕДЕЛЕНИИ СЛЕДОВ ПЛАТИНОВЫХ МЕТАЛЛОВ И ЗОЛОТА В ГЕОЛОГИЧЕСКИХ ОБЪЕКТАХ МЕТОДОМ МАСС-СПЕКТРОМЕТРИИ С ИНДУКТИВНО СВЯЗАННОЙ ПЛАЗМОЙ
Authors: О.А. Тютюнник , С.Н. Набиуллина , К.В. Ирина , М.О. Аносова
Published: December 2024

С целью повышения правильности определения низких (нг г-1) содержаний элементов платиновой группы (Pd, Pt, Rh, Ru, Ir) (ЭПГ) и золота в сложных природных объектах выполнена экспериментальная оценка степени масс-спектральных влияний, возникающих при анализе пород, содержащих значительные избытки некоторых интерферентов. Установлено, что ионообменное отделение матрицы не устраняет наложений со стороны оксидов Zr, Hf, Ta и в ряде случаев требует полного удаления этих элементов из анализируемого раствора. На примере стандартных образцов состава (СОС) пород СЧС-1, СЛг-1, TDB-1, OPY-1, SBC-1 показана эффективность применения сорбента Ln-resin для удаления мешающих элементов, остающихся после отделения матричных компонентов на катионите, в сочетании с последующим определением в режиме низкого и/или среднего разрешения.
Debt load impact on sustainable development of Russian regions
Authors: Lisachkina Yu. S.
Published: December 2024

The paper assesses the level of debt load on sustainable and effective development of the Russian regions under the conditions of sanctions, restrictions, and unstable economic situation. The authors of the study faced the following tasks: to conduct a comparative assessment of regional sustainable development and debt load, to consider the directions for effective management of the load as an element of economic security of the constituent entities, as well as to analyze the economic essence and peculiarities of formation of the Russian regions’ public debt. Various approaches of theoretical and practical plan to the study of the subject of the research have been evaluated and used. The methods and techniques that inﬂuence the level of debt load on sustainable development of the constituent entities through the use and application of various innovative technologies, methods, techniques, etc. at the current stage of economic development of the country have been considered and evaluated. The conducted research results can be applied when developing effective directions to reduce the debt load as a factor that affects the regional sustainable development.
Influence of relationships with mothers on romantic relationships of daughters
Authors: Kozyreva V. V. , Pham V. A. T.
Published: December 2024

The inﬂuence of mother-daughter relationships on how women build romantic relationships in Vietnam and Russia has been studied. Children often imitate their parents in their thoughts and behaviors, so mothers have an important inﬂuence on the process of shaping daughters’ interaction with the environment. The relationship between mother and daughter represents the help daughter receives from her mother and daughter’s appreciation for her mother. Two techniques were used in the research process: “Questionnaire for determining the type of attachment to mother” by M.V. Yaremchuk and “Trent relationship scales” by E. Scharfe. Attachment in relationships with mothers has a similar vector in romantic relationships. Thus, negative attachment in relationships with mothers leads to negative attachment in romantic relationships, while positive attachment in relationships with mothers leads to positive attachment in romantic relationships. It has been revealed that Russian women have more positive relationships with their mothers than Vietnamese women, which leads them to build more positive romantic relationships.
Psychological factors of economic decision-making process
Authors: Mishenin E. S.
Published: December 2024

Personality-psychological aspects inﬂuencing an individual’s economic behavior have been studied. It has been analyzed how cognitive abilities and personality characteristics inﬂuence the decision-making process under uncertainty. Theoretical concepts and empirical studies proving the signiﬁcance of subjective and unconscious factors, such as emotions, biases, and risk perception, when forming complex patterns of economic behavior have been considered. The information processing mechanisms and decision-making stages in the context of economic activity have been considered. It has been demonstrated that psychological factors play a key role in investment and consumer decisions. It has been emphasized that the process of making economic decisions, such as choosing a production object, pricing policy, use of technology, taxation system, consumer choice, and investment, has its own speciﬁcs. The importance of considering general psychological regularities, a manager’s personal characteristics, risk management, and a systematic approach application has been studied. Special attention has been paid to the importance of subjective and unconscious phenomena, such as prejudices and stereotypes, which predetermine complex behavioral patterns of the economic sphere subjects. The study of these factors presents a prospect for further research in the ﬁeld of psychology and economics, contributing to a deeper understanding of decision-making mechanisms and effective strategies development in economic activity management.
Digitalizing an integrated logistics flows of a focus enterprise
Authors: Tyapukhin A. P. , Starodubtsev V. S.
Published: December 2024

The purpose of the study is to clarify and supplement the theory and methodology of design, formation, and optimization of management of integrated, homogeneous, and heterogeneous ﬂows of material, information, ﬁnancial, and human resources in channels, chains, fronts, echelons, and networks of various types. The descriptor and facet classiﬁcation methods and methods of analysis and synthesis, induction and deduction have been chosen as research methods, and binary matrices formed on the basis of qualitative attributes and dichotomies of objects and components of integrated logistics ﬂows management were used as tools. The variants of business system management subjects and objects integration have been substantiated. An end-to-end classiﬁcation of enterprises and relations among them, processes, and logistics operations has been developed for the purpose of digitalization of integrated logistics ﬂows and business systems of various types. The variants of these ﬂows have been deﬁned and digitized, and theoretical and methodological prerequisites for modeling these ﬂows have been created. The value of the study lies in theoretical and methodological prerequisites creation for digitalization of non-physical subjects and objects of integrated logistics ﬂows management, as well as their integration with other physical subjects and objects in order to develop rational management decisions both at the level of links and at the level of the business system.
Assessing the magnitude of multi-site flaring events attributed to supply chain disruptions in oil and gas production basins
Authors: Schissel Colette , Tullos Erin , Allen David
Published: December 2024

Flaring in oil and gas production is used to combust flammable hydrocarbons that otherwise would be vented to the atmosphere. One potential cause of flaring is intermittent disruptions in gas supply chains between oil and gas production sites and gathering and boosting operations. Since gathering and boosting facilities serve multiple production facilities, these types of supply chain disruptions would be expected to cause simultaneous flaring at multiple upstream sites in the regions served by a gathering and boosting facility experiencing a disruption, unless production sites are able to use other gathering and boosting facilities or the production sites immediately shut-in production. To assess the potential magnitude of this type of event, the overall frequency of multiple flares being detected in a localized area (<5 km radius from another flare) was assessed using spatiotemporal patterns in satellite based daily flare detections using the VIIRS Nightfire (VNF) product. Multiple detections in a localized area are unlikely if flaring is caused by independent conditions at individual sites. In contrast, multi-site detections in a localized area may be indicative of potential supply chain disruptions. Hundreds of flares in the Eagle Ford production region in south central Texas that are detected infrequently (<18% observations) were evaluated. For these infrequently detected flares, which account for approximately half of flared gases in the region, 87% had 80-100% of their detections classified as multi-site events. This suggests that efforts to reduce flaring should consider impacts of supply chain disruptions.
Data-driven site occupancy statistics in cubic Prussian Blue
Authors: Baumgart Sebastian , Groß Axel , Sotoudeh Mohsen
Published: December 2024

Sodium-ion batteries are emerging as a cost-effective and sustainable alternative to lithium-ion technology. Prussian blue compounds are demonstrating considerable potential as cathode materials, offering exceptional structural stability and rapid sodium-ion diffusion capabilities. However, in spite of the importance of Prussian Blue for the emerging technology of sodium-ion batteries, surprisingly many atomistic details of the structural changes upon charging and dis-charging are not yet clarified. This study aims to assess stable sodium configurations and derive reliable site occupancy statistics. We employ periodic density functional theory (DFT) to construct the first complete convex hull for the cubic system, encompassing all 24d sites, thereby exploring the entire configurational space available within these compounds. We identify a new, more stable sodium arrangement within the fully sodiated, cubic Prussian Blue structure, which has to be considered for reliable atomistic modeling. The convex hull identifies a single stable intermediate sodium concentration (x = 1), which aligns with observed voltage plateaus in open-circuit voltage measurements. Furthermore, a comparative analysis of the cubic phase and its rhombohedral counterpart is conducted, demonstrating qualitative consistency with phase transition for higher sodium concentrations (x $>$ 1). These results strengthen the evidence that Prussian Blue compounds offer exceptional potential as cathode materials, providing valuable insights into their intricate sodium orderings.
Pivotal role of triethanolamine species in Rhodi-um-catalysed carbon dioxide photoreduction
Authors: Ranscht Alisa , Solé-Daura Albert , Robinson Thomas C. , Ghosh Ashta C. , Benseghir Youven , Alkhurisi Mohammed H. , Tavera-Méndez Cindy-Ly , Bredy Pauline , Quadrelli Elsje Alessandra , Lesage Anne , Canivet Jérôme , Mellot-Draznieks Caroline , Wisser Florian M.
Published: December 2024

To achieve high catalytic activity of artificial photosystems in carbon dioxide reduction or water reduction/oxidation into renewable energy vectors, the use of sacrificial electron do-nors (SEDs) remains mandatory. Despite significant progress in artificial photocatalysis, a detailed understanding of the influence of the SEDs on the reaction mechanism is still lack-ing. We have explored the roles of triethanolamine as SED in the selective CO2 to formic acid photoreduction promoted by various pentamethylcyclopentadienyl rhodium(III)-based porous materials as model catalysts, including polyoxometalate-doped systems. In the pres-ence of anionic polyoxometalates, agglomeration of protonated triethanolamine close to the catalytically active site favours H2 evolution over CO2 reduction, which can be modulated through the degree of confinement imposed by the pores size. Radical trapping experiments and EPR spectroscopy show that triethanolamine-radicals are crucial for a high activity in CO2 reduction. Triethanolamine-radicals act as electron relays in the efficient two-electron activation of the catalyst, regardless whether a homogeneous or a heterogeneous catalyst is used. In contrast, triethylamine-radicals cause deactivation of the one-electron reduced cata-lyst, thus highlighting the effect of different SED-intermediates and underling the im-portance of an appropriate SED.
Iridium-Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands
Authors: Tu Youshao , Lin Xiangfeng , Zhang Chaoshen , Sun Jianwei
Published: December 2024

Iridium-catalyzed asymmetric allenylic substitution represents a useful method for the construction of allenes bearing an allenylic central chirality, but current success has uniformly relied on only one specific chiral bidentate ligand. Herein we address the limitation by the design of a new type of monodentate ligands leading to not only excellent enantiocontrol in allenylic substitution, but also efficient kinetic resolution of α-allenylic alcohols, a new phenomenon never observed before in iridium-catalyzed allenylic substitution. This is also a rare demonstration of non-enzymatic kinetic resolution of α-allenylic alcohols. A range of highly enantioenriched allenylic diarylmethanes and α-allenylic alcohols could be accessed under mild conditions. Control experiments and DFT studies indicated that this process proceeds by an SN1 pathway featuring a rate-determining ionization step followed by ligand-controlled enantiodetermining nucleophilic addition. The newly designed rigid and bulky ligands modified from SPHENOL was believed to assemble the key iridium-bound allenylic carbocation intermediate in a different complexation mode, thus serving as the origin of enantiocontrol and the unprecedented kinetic resolution.
Engineering substrate acceptance of Resveratrol O-Methyltransferase from Vitis vinifera for the selective synthesis of O-methyl protected biobased hydroxystyrenes
Authors: Myrtollari Kamela , Chánique Andrea M. , Kracher Daniel , Herrera Daniela P. , Gutierrez Benavente Joaquín , Schüller Andreas , Kourist Robert
Published: December 2024

Enzymatic decarboxylation of phenolic acids enables the production of biobased phenolic styrenes under mild reaction conditions. However, the free para-phenolic group can lead to undesirable side products during polymerization, giving protection of the free phenolic OH group critical importance for the application in adhesives. Here we present a one-pot two-step cascade reaction, in which phenolic acid decarboxylase from Bacillus subtilis (BsPAD) catalyzes the decarboxylation of coumaric acid, caffeic acid, ferulic acid, and sinapic acid, followed by O-methylation of the intermediate phenolic styrenes by resveratrol O-methyltransferase from Vitis vinifera (VvROMT). The reaction sequence avoids the isolation and purification of the reactive intermediate phenolic styrenes. The O-methyltransferase shows selectivity towards the phenolic styrenes. Characterization of a set of variants with amino acid substitution in the active-site cavity led to the identification of VvROMT L117F/F311W which did not show any activity towards the four phenolic acids. This avoids undesired O-methylation of the starting material, which is not desirable since the decarboxylase does not convert the formed p-methoxyphenolic acids. Furthermore, variation of amino acids in the active site led to the identification of mutants with improved activity for all four phenolic styrenes. The results constitute an important step towards the synthesis of biomass-derived methoxy styrene derivatives whose photopolymerization yields polymers with outstanding adhesion properties.