bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Gevrey ultradifferentiability of weak solutions of an abstract evolution equation with a scalar type spectral operator on the open semi-axis
Authors: Markin Marat V.
Published: September 2019

Given the abstract evolution equation

$$\begin{array}{}
\displaystyle
y'(t)=Ay(t),\, t\ge 0,
\end{array}$$

with scalar type spectral operator A in a complex Banach space, found are conditions necessary and sufficient for all weak solutions of the equation, which a priori need not be strongly differentiable, to be strongly Gevrey ultradifferentiable of order β ≥ 1, in particular analytic or entire, on the open semi-axis (0, ∞). Also, revealed is a certain interesting inherent smoothness improvement effect.
Improved near-UV electroluminescence of ZnO nanorod array LEDs by coupling with a graphene plasmon layer
Authors: Zhang Cen , Qiu Yue , Liu Weizhen , Xu Haiyang , Yang Liu , Wang Chunliang , Liu Yichun
Published: September 2019

The development of short-wavelength light-emitting diodes (LEDs) with high emission efficiency, a fascinating research area, is still necessary because of great scientific interest and practical significance. Here, a graphene plasmon layer treated by oxygen plasma was employed into ZnO nanorod/p-GaN LEDs for a surface plasmon effect. The graphene-decorated heterojunction exhibited an approximately 4-fold improvement of ZnO ultraviolet (UV) electroluminescence (EL) intensity relative to a primitive p-n junction device. Time-resolved spectroscopy and temperature-dependent luminescence measurement indicated that the EL enhancement resulted from the coupling of ZnO excitons with graphene surface plasmons. The current research not only provides an opportunity to construct three-dimensional architecture from a vertical array of one-dimensional nanorods and a two-dimensional graphene layer, but also proposes an effective strategy to improve near-UV emission efficiency in various devices.
Crystal structure of Bis(acetato-κ2
O,O′)-bis[4-(dimethylamino)pyridine-κN]nickel(II), C18H26N4NiO4
Authors: Li Zhuang-Yu , Liu E. , Jian Fang-fang , Liang Tong-ling
Published: September 2019

C18H26N4NiO4, triclinic, P1̄ (no. 2), a = 7.7547(16) Å, b = 7.8666(16) Å, c = 8.2798(17) Å, α = 90.46(3)°, β = 96.24(3)°, γ = 93.25(3)°, V = 501.24(18) Å3, Z = 1, R
gt(F) = 0.0294, wR
ref(F
2) = 0.0873, T = 310 K.
Barrierefreiheit als (k)ein Qualitätskriterium in der ambulanten Gesundheitsversorgung
Authors: Hollederer Alfons
Published: September 2019

Barrierefreiheit in der ambulanten Gesundheitsversorgung umfasst als komplexe Intervention bauliche, personelle, organisatorische und räumliche Maßnahmen für behinderte Menschen im Sinne der UN-Behindertenrechtskonvention. Dieser Artikel exploriert, inwieweit den Menschen mit Behinderungen ein barrierefreier Zugang in der ambulanten Gesundheitsversorgung in Deutschland ermöglicht wird. Er zeigt Datendefizite bei der Erfassung von Barrierefreiheit und den Handlungs- und Forschungsbedarf auf.
Effects of a Novel Rotator Cuff Rehabilitation Device on Shoulder Strength and Function
Authors: Savitzky Jamie A. , Abrams Lindsay R. , Galluzzo Nicole A. , Ostrow Samantha P. , Protosow Tracy J. , Liu Shou-An , Handrakis John P. , Friel Karen
Published: September 2019

Savitzky, JA, Abrams, LR, Galluzzo, NA, Ostrow, SP, Protosow, TJ, Liu, SA, Handrakis, JP, and Friel, K. Effects of a novel rotator cuff rehabilitation device on shoulder strength and function. J Strength Cond Res 35(12): 3355–3363, 2021—The glenohumeral joint, a multiaxial ball and socket joint, has inherent instability counterbalanced by the muscular stability of the rotator cuff (RC) and connective tissue. Exercise has been shown to alleviate pain and disability arising from degenerative changes of the RC due to overuse, trauma, or poor posture. This study compared the training effects of ShoulderSphere (SS), an innovative device that uses resistance to centrifugal force, to TheraBand (TB), a traditional device that uses resistance to elasticity. Thirty-five healthy male and female adults (24.2 ± 2.4 years) were randomized into 3 groups: SS, TB, and control. Five outcomes were assessed before and after the twice-weekly, 6-week intervention phase: strength (shoulder flexion [Fx], extension [Ext], external rotation [ER], and internal rotation [IR]), proprioception (6 positions), posterior shoulder endurance (ShEnd), stability (Upper Quarter Y-Balance Test [YBal] (superolateral [YBalSup], medial [YBalMed], and inferolateral [YBalInf]), and power (seated shot put [ShtPt]). Data were analyzed using a 3 (group: SS, TB, and control) × 2 (time: pre and post) generalized estimating equation. Analyses demonstrated a main effect of time for all strength motions (p < 0.01): YBalInf (p < 0.0001), ShtPt (p < 0.05), and ShEnd (p < 0.0001) but no interaction effects of group × time. There were no main or interaction effects for proprioception. Both SS and TB groups had significant within-group increases in Ext, IR, YBalInf, and ShEnd. Only the SS group had significant increases in ER, Fx, and ShtPt. ShoulderSphere demonstrated comparable conditioning effects with TB and may afford additional strength gains in Fx and ER, and power. ShoulderSphere should be considered a viable alternative in RC conditioning.
Examining Time Perspective Orientation in Suicide Ideation and Suicide Attempts
Authors: Shahnaz Arezoo , Saffer Boaz Y. , Klonsky E. David
Published: September 2019

Introduction: Time perspective orientation (TPO) refers to the way an individual psychologically and behaviorally connects to temporal concepts of past, present, and future. Previous studies have hypothesized that certain types of time perspectives, such as a negative orientation towards the past, predict negative psychological functioning and outcomes, including suicide risk. The current study examines whether differences in TPOs are linked to suicidal thoughts or suicidal acts using two measures of time perspective.

Methods: We recruited a large online U.S.-based sample comprised of three groups: participants with (a) a history of suicide attempts (attempters; n = 107), (b) a history of suicide ideation but no history of attempts (ideators; n = 164), and (c) no history of ideation or attempts (nonsuicidal; n = 194).

Results: A Positive Past (d = 0.71) and Negative Past (d = 0.89) orientation yielded large differences between individuals with a history of suicide ideation and nonsuicidal participants, where Positive Past was elevated among nonsuicidal participants and Negative Past among ideators. These differences were not accounted for by depression or anxiety. However, TPO differences between individuals with a history of suicide ideation and individuals with a history of attempts ranged from negligible to small (d range = 0.03—0.33).

Discussion: The findings suggest that time perspective may be robustly associated with the development of suicide ideation, but only minimally related to suicide attempts among ideators.
A Cross-Cultural Investigation of Co-Rumination Via Cellphone Among Emerging Adults
Authors: Murdock Karla Klein , Carlucci Leonardo , Balsamo Michela
Published: September 2019

Introduction: This study investigated cellphone-mediated co-rumination and its association with emerging adults' anxiety, depression, and social functioning. Comparisons on the basis of gender and nation of residence (United States vs. Italy) were made, and the co-rumination subcomponent of co-brooding was explored.

Method: Participants included 216 undergraduate students recruited in the southeastern United States and 375 students recruited in southern Italy.

Results: Co-rumination via cellphone was associated with higher levels of anxiety and depression and lower levels of social self-efficacy in the U.S. sample. Analyses of the co-brooding element of co-rumination via cellphone revealed its robust association with anxiety and depression in the U.S. sample. In contrast, among Italian emerging adults co-rumination via cellphone was not associated with anxiety or depression and it was positively associated with social well-being. Co-brooding via cellphone was not associated with anxiety or depression in the Italy sample.

Discussion: Cross-cultural and gender differences in co-rumination via cellphone and psychosocial functioning are discussed.
Phosphorylation of Gephyrin in Zebrafish Mauthner Cells Governs Glycine Receptor Clustering and Behavioral Desensitization to Sound
Authors: Ogino Kazutoyo , Yamada Kenta , Nishioka Tomoki , Oda Yoichi , Kaibuchi Kozo , Hirata Hiromi
Published: September 2019

The process by which future behavioral responses are shaped by past experiences is one of the central questions in neuroscience. To gain insight into this process at the molecular and cellular levels, we have applied zebrafish larvae to explore behavioral desensitization to sound. A sudden loud noise often evokes a defensive response known as the acoustic startle response (ASR), which is triggered by firing Mauthner cells in teleosts and amphibians. The probability of evoking ASR by suprathreshold sound is reduced after exposure to repetitive auditory stimuli insufficient in amplitude to evoke the ASR (subthreshold). Although it has been suggested that the potentiation of inhibitory glycinergic inputs into Mauthner cell is involved in this desensitization of the ASR, the molecular basis for the potentiation of glycinergic transmission has been unclear. Through thein vivomonitoring of fluorescently-tagged glycine receptors (GlyRs), we here showed that behavioral desensitization to sound in zebrafish is governed by GlyR clustering in Mauthner cells. We further revealed that CaMKII-dependent phosphorylation of the scaffolding protein gephyrin at serine 325 promoted the synaptic accumulation of GlyR on Mauthner neurons through the enhancement of the gephyrin-GlyR binding, which was indispensable for and could induce desensitization of the ASR. Our study demonstrates an essential molecular and cellular basis of sound-induced receptor dynamics and thus of behavioral desensitization to sound.

SIGNIFICANCE STATEMENTBehavioral desensitization in the acoustic startle response of fish is known to involve the potentiation of inhibitory glycinergic input to the Mauthner cell, which is a command neuron for the acoustic startle response. However, the molecular and cellular basis for this potentiation has been unknown. Here we show that an increase in glycine receptor (GlyR) clustering at synaptic sites on zebrafish Mauthner cells is indispensable for and could induce desensitization. Furthermore, we demonstrate that CaMKII-mediated phosphorylation of the scaffolding protein gephyrin promotes GlyR clustering by increasing the binding between the β-loop of GlyRs and gephyrin. Thus, the phosphorylation of gephyrin is a key event which accounts for the potentiation of inhibitory glycinergic inputs observed during sound-evoked behavioral desensitization.
Peningkatan Aktivitas dan Hasil Belajar Siswa SMA Pada Dimensi Tiga Melalui Model Pembelajaran PBL Berbantuan Alat Peraga
Authors: Anwar Khoirul , Jurotun Jurotun
Published: September 2019

Penelitian ini dilatar belakangi hasil belajar siswa yang belum mencapai kriteria ketuntasan minimal yang telah ditetapkan. Di samping itu, model pembelajaran yang diterapkan  monoton, sehingga aktivitas siswa rendah. Penelitian ini bertujuan untuk mengetahui aktivitas dan hasil belajar siswa pada materi dimensi tiga akibat pembelajaran yang menggunakan model pembelajaran PBL berbantuan alat peraga sederhana berbahan limbah sedotan. Penelitian ini merupakan penelitian tindakan kelas dengan tiga siklus. Subyek penelitian ini siswa kelas XII IPA-1 SMA Negeri 1 Dempet Demak semester gasal  tahun pelajaran 2017/2018. Pengambilan data dalam penelitian ini menggunakan teknik observasi dan angket yang selanjutnya dianalisis sebagai data kualitatif, serta penilaian hasil ulangan blok dianalisis sebagai data kuantitatif. Hasil penelitian menunjukkan bahwa model pembelajaran PBL berbantuan alat peraga sederhana berbahan limbah sedotan dapat meningkatkan hasil belajar siswa dengan rata – rata mencapai 75,44 dengan jumlah siswa yang tuntas mencapai 86,84%, dapat meningkatkan aktivitas siswa menjadi 3,68 (sangat aktif). Respon siswa terhadap model pembelajaran yang telah diterapkan adalah sangat positif (80,99%). Oleh karena itu, model pembelajaran PBL  berbantuan alat peraga sederhana berbahan limbah sedotan dapat diterapkan pada pembelajaran matematika, khususnya dimensi tiga .This  research is based on the learning result of students who have not met the minimum completeness criteria that have been determined, besides that, learning model that is applied  monotonically so that student activity is low. This study aims to determine the activity of student learning result in the three dimensional material due to PBL learning models assisted with simple teaching aids made from straws. This research is a classroom action research with three cycles. The subject of this research is XII IPA-1 of SMAN 1 Dempet of the odd semester in 2017/2018. Taking data in this research used observation and questionnare techniques which are then analyzed as qualitative data and the result of block test are analyzed as quantitative data the result of the study  showed that the PBL learning models assisted with sample teaching aids made from straws can improve student learning results by an average of 75,44 with the number of students who completed 86,84% can improve student activity to 3,68 (very active). Student response to the learning model that has been applied is very positive (80,99%). Therefore, PBL learning models assisted with simple teaching aids made from straws can be applied to mathematic learning, especially the three dimensions.
OTEL İŞLETMELERİNDE İŞTEN AYRILMA NİYETİNİN YORDAYICISI OLARAK İŞ GÜVENCESİ ALGISI: İŞE GÖMÜLMÜŞLÜĞÜN ARACI ROLÜ
Authors: BOZKURT Handan Özçelik , DEMİREL Zümrüt
Published: September 2019

Bu çalışmada, iş güvencesi algısı ile işten ayrılma niyeti arasındaki ilişkinin yönü ve kuvveti ile bu ilişkide işe gömülmüşlüğün nasıl bir rol oynadığını ortaya koymak amaçlanmıştır. Çalışma kapsamında hazırlanan anket formu, Antalya’da faaliyet gösteren 385 otel işletmesi çalışanına uygulanmıştır. Elde edilen istatistiki veriler sonucunda değişkenler arası ilişkiler belirlenmiş ve bu ilişkilerden yola çıkılarak oluşturulan yapısal eşitlik modelini test etmek amacıyla geliştirilen dört araştırma hipotezinin tamamı kabul edilmiştir. Araştırma sonuçlarına göre otel işletmesi çalışanlarının iş güvencesi algıları ve işten ayrılma niyetleri orta düzeyde, iş gömülmüşlük düzeyleri ise düşük düzeydedir. Veri analizleri sonucunda; iş güvencesi algısının işe gömülmüşlüğü pozitif, işe gömülmüşlüğün işten ayrılma niyetini negatif yönde etkilediği sonucuna ulaşılmıştır. İş güvencesi algısının işten ayrılma niyetini azalttığı ve işe gömülmüşlüğün bu ilişkide kısmi aracılık rolü üstlendiği de tespit edilmiştir.
STRATEJİK KARAR VERME SÜRECİNDE SEZGİNİN ÖNEMİ: KAVRAMSAL BİR ÇALIŞMA
Authors: ŞİMŞEK Nazife Orhan , AKGÜN Ali Ekber
Published: September 2019

Örgütlerin varlıklarını koruyabilmeleri ve sürdürülebilir rekabet avantajı elde etmelerinin aldıkları stratejik kararlarla yakından ilişkili olması ve iş hayatının önemli bir parçasını oluşturan stratejik karar verme işleminin günümüz dinamik şartlarına bağlı olarak daha karmaşık bir yapıya bürünmesi sezginin karar verme sürecindeki önemini artırmıştır. Buna rağmen sezginin stratejik karar verme sürecine ne şekilde etki ettiği ve ne gibi sonuçlar doğurduğu konusunda gerek nitel gerek nicel çalışmaların sayısı oldukça sınırlı kalmıştır. Buradan yola çıkarak bu çalışmanın amacı sezgi kavramını ana hatlarıyla incelemek; stratejik karar verme sürecinde sezginin etkin bir yönetimsel araç olduğunu teorik olarak sunmak; sezgi kavramına ait öncüllerin stratejik karar verme performansı ve hızı üzerindeki etkisini ve sonuçlarını gösteren kavramsal bir model önermektir. Çalışmanın ilk bölümünde epistemolojik bakış açısıyla ele alınmış sezgi kavramının temel özellikleri açıklanmış, ardından stratejik karar verme eyleminin tanımı ve önemine değinilerek sezgi kavramına vurgu yapan çalışmalar kronolojik olarak incelenmiştir. Son olarak yapılan çalışmalardan yola çıkarak kavramsal bir model önerilmiş ve çalışma sonuç ve öneriler kısmıyla tamamlanmıştır.
Multiobjective nonfragile fuzzy control for nonlinear stochastic financial systems with mixed time delays
Authors: Yang Yang , Xia Jianwei , Zhao Jianli , Li Xiaodi , Wang Zhen
Published: September 2019

In this study, a multiobjective nonfragile control is proposed for a class of stochastic Takagi and Sugeno (T–S) fuzzy systems with mixed time delays to guarantee the optimal H2 and H∞ performance simultaneously. Firstly, based on the T–S fuzzy model, two form of nonfragile state feedback controllers are designed to stabilize the T–S fuzzy system, that is to say, nonfragile state feedback controllers minimize the H2 and H∞ performance simultaneously. Then, by applying T–S fuzzy approach, the multiobjective H2/H∞ nonfragile fuzzy control problem is transformed into linear matrix inequality (LMI)-constrained multiobjective problem (MOP). In addition, we efficiently solve Pareto optimal solutions for the MOP by employing LMI-based multiobjective evolution algorithm (MOEA). Finally, the validity of this approach is illustrated by a realistic design example.
Global attracting solutions to Hilfer fractional differential inclusions of Sobolev type with noninstantaneous impulses and nonlocal conditions
Authors: Wang JinRong , Ibrahim Ahmed Gamal Gamal , O’Regan Donal
Published: September 2019

In this paper, we establish the existence of decay mild solutions on an unbounded interval of nonlocal fractional semilinear differential inclusions with noninstantaneous impulses and involving the Hilfer derivative. Our argument uses fixed point theorems, semigroup theory, multi-functions and a measure of noncompactness on the space of piecewise weighted continuous functions defined on an unbounded interval. An example is provided to illustrate our results.
CORRELATION OF FACTORING AGREEMENT WITH CERTAIN TYPES OF CONTRACTS IN UKRAINE
Authors: Ivanytskyi A. V.
Published: September 2019

The legal construction of a factoring contract has separate features similar to other business agreements. At the same time, factoring is characterized by a number of certain features, which makes it possible to distinguish it as an independent type of economic agreement with its own, specific legal regulation. Doctrinal literature suggests that factoring is not a separate type of obligation, but is instead considered as a subspecies or specific form of other treaties. In order to refute such judgments, we consider it necessary to clarify the difference between factoring agreements and related categories. The article improves the comparative characteristics of the factoring contract and the cession contract – a number of different characteristics are revealed, which allow to differentiate factoring relations from the relations of the cession. Using the comparative method, the differences of the contract of faking from the different
types of contracts are investigated on the basis of the subject of contracts, independence, payment, formof conclusion of contracts, legal personality of the parties, sources of legal regulation, complex nature, etc. Further developed the provision on the economic and legal nature of the factoring agreement, which objectively corresponds to its nature, features and characteristic specificity, based on the analyzed theoretical approaches to determining the legal nature of the factoring agreement, foreignexperience, case law and case law international law and the author’s own positions. It is proved that the factoring contract is an independent and complete economic obligation, which has its own characteristic features and features that make it possible to distinguish the factoring contract with similar legal structures. On the basis of a systematic study of the relation of the factoring contract with certain types of contracts, new scientific provisions have been developed, and proposals for improvement of legislation on a number of issues have been substantiated.
CIVIL SERVICE RELATIONS AS A SUBJECT OF PUBLIC-LEGAL DISPUTE
Authors: Cherniakhovych I. E.
Published: September 2019

The article is devoted to the definition of the state-service relations as the subject of a public-legal dispute, and on this basis develop separate proposals for the improvement of the current legislation and the practice of its application.
The article determines that the subject of a public-legal dispute is administrative-legal relations, the object of which is: adoption, passing, dismissal from the civil service. The above applies to: state political positions and positions in state collegial bodies; positions
of judge and prosecutor; places of work within the military, alternative non-military service, regardless of the power of the rights and obligations provided by the corresponding place of work; places of work within another civil service.
Additional criteria for determining the administrative jurisdiction of a public-legal dispute are: direct practical fulfillment of tasks and functions of the state; the existence of labor relations between the civil servant and the body, the institution in which it operates.
The jurisdiction of administrative courts includes public-law disputes arising from the relations of acceptance, employment, dismissal from work in public institutions, subject to compliance with the criteria specified in paragraph Such criteria as the existence of a power of attorney within the scope of the labor obligation or the basis for the establishment of the relevant labor relations (contract
or oath of a public servant) should not be decisive for the attribution of the public law disputes under consideration to the jurisdiction of administrative courts. It is expedient to publish the Plenary Session of the Supreme Court clarifications regarding the allocation and necessity of applying the above-mentioned provisions and criteria.
The expediency of inclusion of relations in connection with activity of persons on political positions to a circle of state-service relations as a subject of jurisdiction of administrative courts, with the exceptions provided by the law, is substantiated. Similar types of relations that arise in connection with the occupation of positions in local self-government bodies are inappropriately attributed to the range of these relations as an object of administrative legal proceedings, since they constitute another type of public service relationship.
ESTIMATION OF TERMS OF LOSS OF MARKET VALUE OF SOME CATEGORIES OF GOODS IN THE COURSE OF CONDUCTING FORENSIC COMMODITY EXAMINATION
Authors: Liapun N. M. , Pavlichenko D. H.
Published: September 2019

In the current conditions of the Ukrainian economy, the greatest attention should be paid to consumer protection, as consumers are the main participants in market relations. Thus, in accordance with the regulatory legal acts that contain provisions on the consumer rights protection and regulate trade activity in Ukraine, a list of proper quality commodities that are not subject to exchange (return)
is approved.
The legal acts regulating the relations between consumers of goods, works and services and producers and sellers of goods, work performers and service providers of various forms of ownership, as well as contain provisions on the protection of consumer rights and regulate trade activity in Ukraine were analyzed in this research paper.
The problem that is dealt in this research paper is not covered enough because the greatest attention in the field of commodity examination is paid to the examination of the quality of goods and their compliance with regulatory acts, therefore, it requires more thorough research. The importance of introducing homogeneous approaches and conditions under which some categories of proper quality commodities, after their purchase by consumers for private use, lose investment attractiveness in the course of conducting forensic commodity examination.
This research paper deals with the problems which forensic experts face when judicial authorities appoint commodity examination, in which it is necessary to establish the market value of such categories of goods as food products, medicines and hygiene products, as well as some non-food products of the proper quality which were purchased by consumers for private use. As a rule, at the time of examination, the above groups of goods are in a used condition.
On the basis of the conducted research it is possible to summarize that non-exchangeable (returnable) goods of proper quality, after purchase by end users, have value only for the consumer of such products. Accordingly, these products lose market value due to the influence of subjective judgments of the consumer of goods of this category in the secondary market, even if the product has a short operation life in connection with the loss of some or all of the consumer properties as a result of its intended use.
The solution to this situation is proposed through raising questions by investigating and judicial authorities to an expert in the course of conducting of a forensic commodity examination on determining the size of the material damage caused to the owner of the property as a result of the committed offense or damage to property.
Characteristics of NiO present in solids obtained from hydrotalcites based on Ni/Al and Ni-Zn/Al
Authors: Meza Fuentes Edgardo , Rodriguez Ruiz Johana Ines , Rangel Santos Maria do Carmo
Published: September 2019

NiO has a variety of applications, mainly in the production of electrochemical sensors and of metallic nickel. In addition, it is widely used as catalysts to produce hydrogen from natural gas. In this work, hydrotalcites based on nickel-aluminum and nickel-zinc-aluminum were synthesized, calcined at 500 °C and studied by different techniques. It was observed that nickel-aluminum hydrotalcites are thermally more stable, collapsing at higher temperatures than hydrotalcites containing zinc. During calcination, aluminum is incorporated into NiO lattice, leading to a decrease in crystallographic parameters. However, zinc decreases this effect, favoring the formation of NiO with lattice parameters close to pure nickel oxide. Zinc also contributes to the formation of smaller NiO particles, which is very useful for its use as a catalyst. In addition, aluminum led to a distortion in NiO lattice, an effect that is minimized by zinc, showing that it hinders the incorporation of Al3+ in the NiO lattice.
Relationship Between Anxiety, Dental Fear of Parents and Collaboration of Children to Dental Treatment
Authors: Munayco Pantoja DDS Evelyn R. , Mattos-Vela DDS, MSc, PhD Manuel A. , Torres Ramos DDS, MSc, PhD Gilmer , Blanco Victorio DDS, MSc Daniel J.
Published: September 2019

In the clinical history of a child, it is not taken into account any scale that evaluates the anxiety and fear experienced during dental treatment. This would help to define the way to approach the patient and perform a successful treatment. The objective of this study was to determine the relationship between anxiety, dental fear and collaboration of parents and children towards dental treatment. A descriptive and transversal study was carried out. The study’s sample was collected from 177 children of both sexes from 3 to 6-year-old, who visited a health institute for a dental appointment, and also their respective parents. A data collection form was prepared for each patient, which included four evaluation scales: the dental fear questionnaire, the Corah anxiety scale, the Children’s Fear Scale and the Venham graphic test. At the end of the treatment, the child's behavior was evaluated using the Frankl scale. In regard to fear, parents presented little or no (55.9%) and children, under fear (87.6%) in a greater percentage. In reference to anxiety, parents presented low anxiety (57%); children, in their majority, were not anxious (64.4%), and their behavior was positive (71.2%). As a result, anxiety caused by the dental treatment in children and parents is not related; nonetheless, fear is. In addition, there is no relationship between anxiety and fear that parents may experience with regard to the child's collaboration. However, the child's collaboration is related to the fear and anxiety that they may experience during dental treatment.
Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice
Authors: de Groot Theun , Ebert Lena K. , Christensen Birgitte Mønster , Andralojc Karolina , Cheval Lydie , Doucet Alain , Mao Cungui , Baumgarten Ruben , Low Benjamin E. , Sandhoff Roger , Wiles Michael V. , Deen Peter M.T. , Korstanje Ron
Published: September 2019

Significance Statement

Lithium causes nephrogenic diabetes insipidus and hypercalcemia in 20% and 10% of patients, respectively, and may lead to metabolic acidosis. To determine the potential role of genetic predisposition in these adverse effects, the authors fed mice from 29 genetically different inbred strains a normal or a lithium-supplemented diet. Some strains developed adverse effects, whereas others did not. Genome-wide association studies revealed eight loci containing different candidate genes that were associated with development of lithium-induced nephrogenic diabetes insipidus. Of these, Acer2 is specifically expressed in the collecting duct; mice lacking Acer2 were more likely to develop lithium-induced nephrogenic diabetes insipidus. These findings demonstrate the importance of genetic variation in susceptibility for lithium-induced adverse effects in mice, and the genes identified may facilitate subsequent identification of human susceptibility genes.

Background

Lithium, mainstay treatment for bipolar disorder, causes nephrogenic diabetes insipidus and hypercalcemia in about 20% and 10% of patients, respectively, and may lead to acidosis. These adverse effects develop in only a subset of patients treated with lithium, suggesting genetic factors play a role.

Methods

To identify susceptibility genes for lithium-induced adverse effects, we performed a genome-wide association study in mice, which develop such effects faster than humans. On day 8 and 10 after assigning female mice from 29 different inbred strains to normal chow or lithium diet (40 mmol/kg), we housed the animals for 48 hours in metabolic cages for urine collection. We also collected blood samples.

Results

In 17 strains, lithium treatment significantly elevated urine production, whereas the other 12 strains were not affected. Increased urine production strongly correlated with lower urine osmolality and elevated water intake. Lithium caused acidosis only in one mouse strain, whereas hypercalcemia was found in four strains. Lithium effects on blood pH or ionized calcium did not correlate with effects on urine production. Using genome-wide association analyses, we identified eight gene-containing loci, including a locus containing Acer2, which encodes a ceramidase and is specifically expressed in the collecting duct. Knockout of Acer2 led to increased susceptibility for lithium-induced diabetes insipidus development.

Conclusions

We demonstrate that genome-wide association studies in mice can be used successfully to identify susceptibility genes for development of lithium-induced adverse effects. We identified Acer2 as a first susceptibility gene for lithium-induced diabetes insipidus in mice.
Implantação de Polo de Educação a Distância no Exterior: Panorama Atual
Authors: Taveira Camila Marques de Andrade Nascimento , De Carvalho Alexandre Fabiano , Diniz Juvenato Pevidor , Badaró Lúbia Siqueira
Published: September 2019

O acesso à Educação é um direito estipulado na Constituição brasileira vigente, sendo dever do Estado zelar pela sua oferta com qualidade. O advento da EaD, por superar o desafio da distância, democratiza a Educação no país. Entretanto, para a implantação de cursos na modalidade a distância é condição obrigatória a existência de polos de educação a distância. Este trabalho tem como objetivo verificar o panorama atualizado da implantação de polos de educação a distância no exterior, compilando dados sobre legislação, gestão administrativa e financeira relacionados a essa implantação disponíveis na literatura. Inicia descrevendo a legislação brasileira que possibilitou a implantação dos polos de educação a distância no Brasil e no exterior, bem como destaca as instituições pioneiras na criação desses polos no estrangeiro, além de refletir sobre as técnicas para gestão administrativa e financeira deles. Para o desenvolvimento do estudo foi realizada uma revisão da literatura para compilar as informações disponíveis. Por meio do desenvolvimento da presente pesquisa, foi possível observar que, uma vez superados os desafios impostos pela regulamentação de uma legislação que permita a existência dos polos de educação a distância e, uma vez ocorrida a implantação dessas unidades no exterior, surgem novos desafios que se opõem à sua concreta implementação. São desafios ligados à gestão administrativa e financeira desses polos e que envolvem fatores diretamente relacionados à estrutura administrativa, pedagógica e à capacitação de seus gestores.
Collaboration and critique
Authors: Matza Tomas
Published: September 2019

What is the place for critical ethnography in global health and other related forms of international intervention? This essay explores this question through my experience collaborating with a nongovernmental organization (NGO) working to improve children’s well-being in El Salvador and with a team of quantitatively oriented researchers evaluating the NGO’s project. I adopt as an analytic lens one of the metrics the researchers used – the Battelle Developmental Inventory – in order to explore the possibilities for dialogue among quantitative and qualitative methods (and researchers). At issue is the place that critique can have in such dialogues, particularly when the aims of NGOs, public health researchers, and ethnographers can sometimes be at odds. Ultimately, I make the case that viewing critique as a praxis, keeping an eye on the commensurability of aims, and being prepared for occasional productive friction are some practical steps for bringing critical ethnographic perspectives into contact with interventions.
Advocating for evidence in birth
Authors: Ford Andrea
Published: September 2019

The notion of ‘evidence’ circulates in two realms of current maternity care: biomedical ‘evidence-based’ obstetrics and efforts to reform conventional obstetric practices. I observed that in California’s childbearing culture, ‘evidence’ is a boundary object that allows diverse actors to engage in related conversations despite fundamentally different assumptions about what evidence is or does. Sometimes these actors form productive hybrids and other times they talk past one another. This article uses recent work from the history and philosophy of science to distinguish the biomedical use of evidence, which is based on controlled experiments to prove cause and effect, from reformists’ use of evidence, which foregrounds patient outcomes. Using Stengers’s classification of doctors, charlatans, and curers, I discuss the role of rationality and experience in producing authoritative knowledge. Reformists’ use of evidence, in effect, challenges medical power dynamics on what they perceive to be the terms of medical authority itself; in doing so, it has the potential to fundamentally alter who is the primary beneficiary of medical protocols. The challenge is continuing to use evidence in a way that doesn’t simply ossify a new set of norms, but becomes increasingly capacious, flexible, specific, and patient centered.
Spirit and mind
Authors: Selim Nasima
Published: September 2019

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О «непутевых черничках» и «птичках небесных»: парадокс монастырской тотальности
Authors: Медведева Ксения Сергеевна
Published: September 2019

В статье рассматривается специфика устройства современных православных монастырей в России. В частности, анализируются дихотомия «мир – монастырь» и разделение внешнего и внутреннего порядка. Для анализа использованы материалы, находящиеся в открытом доступе (вебсайты церковных организаций), а также полевые материалы, собранные автором в ходе включенного наблюдения и неструктурированных интервью с 2012 по 2016 гг. в женских православных монастырях. Автор делает вывод о том, что несмотря на дихотомию «мир – монастырь», которая проходит как в реальном, так и в виртуальном пространстве, современные российские монастыри скорее не «убежища от мира», как полагал Эрвин Гоффман, а прибежища для него. Дихотомия «мир – монастырь» поддерживается пространственной организацией монастыря, его писаными и негласными правилами, которые, впрочем, могут нарушаться с обеих сторон. Монастырский порядок регулируется внешними и внутренними механизмами. К внешним инструментам можно отнести церковные документы, с которыми насельники обычно знакомы плохо, правила и нормы поведения, усваиваемые в процессе социализации в монастыре. Знание устава предполагает не знакомство с конкретным текстом, а скорее успешную социализацию, усвоение принятых в данном сообществе норм и правил поведения, которые могут быть не зафиксированы в письменных документах. Кроме этого, внешне монастырская жизнь регулируется особым распорядком, который может различаться в разных обителях, но служит одной цели – при внешнем однообразии создать условия для внутренней жизни. Внешние механизмы поддержания порядка необходимы, но недостаточны: порядок в том числе зависит от главного в монастыре – «внут­ренней жизни», самодисциплины самих насельников и реализации ими своей свободы. Кажущаяся несвобода в виде внешней регуляции, которую обеспечивает монастырь, парадоксальным образом конституирует свободу внутренней жизни его насельников. Особые условия и акцент на внутренней жизни являются парадоксом монастырской тотальности и отличают монастырь от других тотальных институтов.
SAUNA KULLANIMI SONRASI GELİŞEN AKUT SOLUNUM YETMEZLİĞİ OLGUSU
Authors: ÇAKIR Münire , EVRİMLER Şehnaz
Published: September 2019

Sauna kullanımı çeşitli akut ve geçici,
kardiyovasküler ve hormonal değişikliklere neden olsa da çoğu sağlıklı erişkin
ve çocuk tarafından iyi tolere edilir. Ancak, akut respiratuvar infeksiyon
geçirenlerin sauna kullanmamaları önerilmektedir. Ayrıca, sempatomimetik
ilaçlar saunada taşikardi ve aritmileri provoke edebilir. Sauna kullanımının kontrendikasyonları
ise; stabil olmayan anjina pektoris, yakında geçirilen miyokard infarktüsü,
ciddi aort stenozu, dekompanze kalp yetmezliği ve yaşlılarda görülen ciddi
ortostatik hipotansiyondur.

Sauna veya jakuzi kullanımına bağlı
olarak günümüze değin bildirilen olgulardaki en yaygın akciğer patolojileri
hipersensitivite pnömonitleridir. Sağlıklı, genç bir erişkin olan olgumuz,
sauna kullanımı ve özellikle saunada mentol buharı soluma sonrasında bayılmış
ve ardından akut solunum yetmezliği tablosunda acilen hastaneye yatırılmıştır.
Başvurusunda çekilen toraks bilgisayarlı tomografisinde her iki akciğer
parankiminde simetrik, diffüz, alt loblarda daha belirgin olmak üzere
sentrilobüler konsantrasyon ve peribronkovasküler dağılım gösteren buzlu cam
opasiteleri görülmüştür. Olguya antibiyotik, antiviral,
steroid, mukolitik ilaçlar, intravenöz hidrasyon ve oksijen tedavileri
uygulanmış ve hasta birkaç gün içinde taburcu edilmiştir. Taburcu olduktan beş
gün sonra çekilen kontrol grafisi ve solunum fonksiyon testleri normal bulunan
hasta, bu klinik ve radyolojik bulgulara neden olabilecek hastalıklar literatür
eşliğinde tartışılarak sunulmuştur.
A justa medida da morte: O nascimento e a morte do eu em El olvido que seremos de Héctor Abad Faciolince
Authors: Belcastro de Almeida Guilherme
Published: September 2019

Este trabalho procura ler El olvido que seremos, de Héctor Abad Faciolince, a partir da articulação de três eixos teóricos principais: a autobiografia, o luto e os relatos de filiação. Com relação ao problema da autobiografia, a leitura aproxima-se de Paul de Man (1991) e Jacques Derrida (2009), que tocam diretamente na relação entre autobiografia e morte, o que leva à questão do luto, lida junto à Freud (2011) e Allouch (2004). A hipótese de leitura é que o romance precisa acrescentar um terceiro elemento à essa discussão: os relatos de filiação (Demanze, 2012; Premat, 2016).
Eficácia, segurança e aspectos regulatórios dos medicamentos órfãos para doenças raras: o caso Zolgensma®
Authors: Riera Rachel , Bagattini Ângela Maria , Pachito Daniela
Published: September 2019

Objective: to discuss the regulatory process of drugs for rare diseases in Brazil, based on the Zolgensma® case, and to critically evaluate the evidence so far available on the efficacy and safety of Zolgensma® for treating spinal muscular atrophy (SMA). Methods: descriptive study conducted at the Health Technology Assessment Center of the Sírio Libanês Hospital (NATS-HSL) in June 2019. Results: in April 2019, the use of Zolgensma® for SMA was regulated in the United States based on two open-lable (unmasked), non-comparative (and therefore non-randomized) studies. These methodological limitations increase the uncertainty related to study results. The National Agency of Sanitary Surveillance (Anvisa) has approved strategies to regulate the process and specific deadlines for completing the appraisal process of new medicines for rare diseases, such as Zolgensma®. Conclusion: it is necessary to broaden the debate about the process of regulation and incorporation of orphan drugs for rare diseases in Brazil. This debate should include evidence related to the effects (benefits and risks) of these drugs, and greater transparency of the criteria indispensable for granting registration and recommendation of incorporation into health systems.
Breve panorama da judicialização da saúde no Brasil e os reflexos dos julgamentos dos recursos repetitivos pelos Tribunais Superiores
Authors: Ribeiro Catarina de Sá Guimarães , Wanderley Queiroz Cristina Câmara
Published: September 2019

Objectives: in view of the new parameters established in the recent judgments of repetitive appeals that are representative of controversies in health demands by the Brazilian Supreme Court, the study analyzed the decision-making profile of the lower courts based on this fact. Methods: the judgments handed down by the Pernambuco Judiciary were analyzed after the publication of the respective minutes of judgment in the electronic Justice Gazette, the initial landmark of the obligation to observe the established theses, according to the rule of §11, art. 1.035 of the Code of Civil Procedure. Results: the results showed shy changes in the way health demands were resolved, with attachment to old ways of deciding, without deepening the necessary multidisciplinary discussion that the issue requires. Discussion and conclusions: the results obtained may contribute to alert to the need to resolve the judicialization of health rationally and in line with the binding theses defined by the Superior Courts.
The European Parliament as an Arena and Agent in the Politics of Climate Change: Comparing the External and Internal Dimension
Authors: Wendler Frank
Published: September 2019

Climate change policy is a key example for globalized multi-level governance, involving the European Parliament (EP) both as legislator of internal European Union (EU) regulation and discursive agent in global climate negotiations. Based on the comparison of decision-making in external and internal climate change policy, the article investigates the link between the role of the EP as a political actor and arena for the interaction of competing party groups: Does EP involvement in negotiations on legally binding legislation prompt or constrain partisan polarization in comparison to declaratory statements about future goals of climate action? Harnessing a discursive institutionalist theoretical framework, the article compares EP resolutions about annual Conferences of the Parties (COPs 20 to 24) with the revision of four legislative acts for Phase IV of EU Climate Action: namely, emissions trading, effort sharing between Member States, the promotion of renewable energies, and energy efficiency standards. Using roll-call voting data and the review of legislative documentation, the contribution tracks the emergence and negotiation of political conflict in these two sets of cases. Overall, the case studies indicate a low level of external politicization, as indicated by low party group polarization, internalization of political conflict at the committee level, and compromise-building between issue dimensions.
Ortaokul 8. Sınıf Öğrencilerine Yönelik Geliştirilen Cinsel Sağlık Psiko-Eğitim Programının Etkililiği
Authors: ÇİTİL AKYOL Canan , KUTLU Mustafa
Published: September 2019

Bu
araştırmanın amacı, ortaokul 8. sınıf öğrencilerine yönelik hazırlanan cinsel
sağlık psiko-eğitim programının öğrencilerin ergenlik dönemi, istismar ve
toplumsal cinsiyet konuları ile ilgili bilgi düzeyleri ve tutumları üzerindeki
etkisini test etmektedir. Bu çalışmada, ön test-son test kontrol gruplu yarı
deneysel desen kullanılmıştır. Deney grubunda 24 (10 erkek-14 kız) öğrenci;
kontrol grubunda 24 (10 erkek-14 kız) öğrenci olmak üzere toplam 48 öğrenci bu
çalışmanın araştırma grubunu oluşturmaktadır. Deney grubundaki katılımcılara
Cinsel Sağlık Psiko-Eğitimi uygulanırken; kontrol grubundaki katılımcılara
konuyla ilgili herhangi bir müdahale yapılmamıştır. Araştırma bulguları, deney
grubuna uygulanan cinsel sağlık eğitimi programının öğrencilerin ergenlik
dönemi ve toplumsal cinsiyet konularındaki bilgi düzeylerinde kontrol grubuna
göre anlamlı bir farklılık olduğunu (p<.05); fiziksel, duygusal, cinsel
istismar konularındaki bilgilerini artırmada ise kontrol grubuyla deney grubu
arasında anlamlı bir farklılığın olmadığını göstermektedir (p<.05).
Araştırma sonuçları cinsel sağlık eğitiminin 8. sınıf öğrencilerinin ergenlik
dönemi ve toplumsal cinsiyet konularındaki bilgilerini olumlu yönde
arttırdığını, istismar konusundaki bilgilerini ise etkilemediğini göstermektedir.
The Degree of Overjet and Anterior Traumatic Dental Injury in the Mixed Dentition: A Single-Center Experience
Authors: Munro Monica , Ackerman Marc B
Published: September 2019

Objective. The objective of this retrospective chart review study was twofold. The first was to determine whether there is a correlation between the degree of overjet and the type of anterior traumatic dental injury (ATDI) in the mixed dentition. The second was to assess whether the decision to not treat young patients with prominent upper front teeth for trauma prevention resulted in a greater number of ATDI's in patients of record from a single-center. Study Design. The authors conducted a retrospective chart review of patients presenting to the Boston Children's Hospital (BCH) Emergency Department with an ATDI in the mixed dentition between October 2011 and March 2016.

Results. Patients with an overjet less than or equal to 4 millimeters experienced all types of ATDI with greater frequency than those patients with an overjet greater than 4 mm.

Conclusions. Our experience at BCH described in this study has led us to believe that a patient's risk of suffering an ATDI has more to do with the type of activities they participate in rather than the degree of their overjet.
LONG-TERM FOLLOW-UP ASSESSMENT OF POTENTIAL ADVERSE EFFECTS AFTER RADIOFREQUENCY ABLATION IN AN INFANT (A CLINICAL CASE)
Authors: Dzhaffarova O. Yu. , Svintsova L. I. , Plotnikova I. V. , Krivolapov S. N.
Published: September 2019

The article presents a long-term follow-up of the patient who underwent an intracardiac electrophysiological study (EPS) and radiofrequency ablation (RFA) of focal tachycardia at the age of 2 months. 12 years after the indexed procedure, Wolff-Parkinson-White (WPW) syndrome was diagnosed and required repeat RFA procedure. The atrial map of the first ablated zone was reconstructed using non-fluroscopic mapping system. EPS reported the absence of myocardial electrical activity reduction zones. There were no damages after the indexed ablation. Our findings suggested the normal electrical activity of the atrial tissue in the long-term period following the indexed RFA. This clinical case reports the absence of post-ablation necrosis and successful restoration of the electrical activity of the myocardium with the child’s growth.