bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex Difference in Coronary Artery Spasm Tested by Intracoronary Acetylcholine Provocation Test in Patients with Nonobstructive Coronary Artery Disease
Authors: Park Ji Young , Choi Se Yeon , Rha Seung-Woon , Choi Byoung Geol , Noh Yung-Kyun , Kim Yong Hoon
Published: September 2022

Introduction. Cardiovascular diseases manifest differently in men and women. The purpose of this study is to compare the sex difference in the characteristics of coronary artery spasm (CAS) in patients with nonobstructive cardiovascular disease (NOCVD) and the clinical outcomes in accordance with sex in CAS patients. Methods. The study analysed 5,491 patients with NOCVD who underwent an acetylcholine provocation test from November 2004 to May 2014 for evaluation of chest pain. CAS was defined as greater than 70% of luminal narrowing of the artery during the acetylcholine provocation test. Results. The patients were divided into men (n = 2,506) and women (n = 2,985). Mean follow-up days were 1,218 ± 577 days. To adjust for confounding factors, the propensity score matching (PSM) analysis was performed in all patients and among the CAS patients. After PSM analysis, a total of 1,201 pairs in all patients and a total of 713 pairs in CAS patients were generated. In all patients, women showed significantly less incidence of CAS compared with men (62.3% vs 50.9%,

P
<
0.01

). Myocardial bridge (MB) and moderate stenosis were less prevalent in women, while transient ST elevation and ischemic chest pain during provocation were more frequent in women. In CAS patients, men had a higher incidence of multivessel spasm than women (35.7% vs. 29.7%,

P
<
0.01

). Old age, dyslipidemia, and MB were independent risk factors of CAS in both men and women. In CAS patients, there was no statistical differences for various individual and composite major outcomes up to five years in either men or women. In men with CAS, old age was a risk factor of a 5-year major adverse cardiac event (MACE), and moderate stenosis was a risk factor of both 5-year MACE and 5-year recurrent angina. In women with CAS, mild stenosis was a risk factor of 5-year MACE, while myocardial bridge was a risk factor of 5-year recurrent angina. Conclusions. In this study, there were sex differences in the angiographic and clinical parameters during the acetylcholine provocation test, incidence of CAS, risk factors of CAS, 5-year MACE, and recurrent angina. Old age, dyslipidemia, and MB were independent risk factors of CAS in both sexes. However, major clinical outcomes up to five years in CAS patients were not different according to sex.
Application of Fusion of Fuzzy Mathematical Clustering Analysis in Enterprise Financial Management Cloud Platform
Authors: Zhang Xianli
Published: September 2022

The enterprise financial management cloud platform can conveniently obtain computing resources such as network, storage, and services according to actual needs based on the network. The maintenance of resources can be realized in a general way, and various computers and their storage resources can be effectively integrated and effectively utilized. But internal conflicts within the company, such as asset management issues, can seriously hinder the company’s long-term growth. In order to solve the above problems, this paper analyzes the actual needs of the current financial information management personnel of enterprises and the business process of financial management. Combined with the characteristics and requirements of the current enterprise financial management, the integrated fuzzy mathematics cluster analysis was introduced to complete the design and implementation of the financial IMS, and to build a modern, systematic, and scientific enterprise management system. It greatly improves the financial level of the enterprise and the intelligent level of enterprise management, provides objective and strong support for enterprise decision-making through the enterprise’s financial management ability, and finally realizes the long-term development of the enterprise. The prediction effect of the samples under the FCM is shown in Table 3. The prediction effect of the training samples of the normal company is 83.33%, and the prediction effect of the training samples of the ST company is 80%. The test sample prediction effect of normal company is 83.33%, the test sample prediction effect of ST company is 80%, and the comprehensive prediction effect under the FCM is 85.28%.
Construction of a Prediction Model for the Mortality of Elderly Patients with Diabetic Nephropathy
Authors: Wang Li , Lv Yan
Published: September 2022

To construct a prediction model for all-cause mortality in elderly diabetic nephropathy (DN) patients, in this cohort study, the data of 511 DN patients aged ≥65 years were collected and the participants were divided into the training set (n = 358) and the testing set (n = 153). The median survival time of all participants was 2 years. The data in the training set were grouped into the survival group (n = 203) or the death group (n = 155). Variables with P ≤ 0.1 between the two groups were selected as preliminary predictors and involved into the multivariable logistic regression model and the covariables were gradually adjusted. The receiver operator characteristic (ROC), Kolmogorov-Smirnov (KS), and calibration curves were plotted for evaluating the predictive performance of the model. Internal validation of the performance of the model was verified in the testing set. The predictive values of the model were also conducted in terms of people with different genders and ages or accompanied with chronic kidney disease (CKD) or cardiovascular diseases (CVD), respectively. In total, 216 (42.27%) elderly DN patients were dead within 2 years. The prediction model for the 2-year mortality of elderly patients with DN was established based on length of stay (LOS), temperature, heart rate, peripheral oxygen saturation (SpO2), serum creatinine (Scr), red cell distribution width (RDW), the simplified acute physiology score-II (SAPS-II), hyperlipidemia, and the Chronic Kidney Disease Epidemiology Collaboration equation for estimated glomerular filtration rate (eGFR-CKD-EPI). The AUC of the model was 0.78 (95% CI: 0.73–0.83) in the training set and 0.72 (95% CI: 0.63–0.80) in the testing set. The AUC of the model was 0.78 (95% CI: 0.65–0.91) in females and 0.78 (95%CI: 0.68–0.88) in patients ≤75 years. The AUC of the model was 0.74 (95% CI: 0.64–0.84) in patients accompanied with CKD. The model had good predictive value for the mortality of elderly patients with DN within 2 years. In addition, the model showed good predictive values for female DN patients, DN patients ≤75 years, and DN patients accompanied with CKD.
A Metadata-Based Approach to the Integration of Educational Resources in Ethnic Traditional Physical Education
Authors: Chen Xiaodan
Published: September 2022

Ethnic traditional sports are a comprehensive interdisciplinary field that draws on and integrates theories and methods from related disciplines, particularly anthropology, to reveal the laws governing the emergence and development of ethnic traditional sports. The evolution of ethnic traditional sports has historically contributed to the construction of theoretical systems, the transmission of traditional culture, the formation of distinctive fitness techniques, the intensification of socioeconomic interests, and the development of cultural self-confidence. The majority of ethnic traditional sports teaching resources, however, are unstructured data including documents, images, animations, programs, tools, and videos. They rely heavily on ethnic traditional physical education teachers for instructional design, and there is no way to create a unified integration and sharing platform. From the preparation, supplementation, and description of resource metadata specifications to the clustering, integration, and cataloging of digital resources and the implementation of retrieval and service interfaces, this paper focuses on the effective integration of high-quality digital traditional ethnic sports resources in the process of network sharing.
Sustainable Concrete Columns with GGBS and Industrial Sand: A Comparative Study on Destructive and Nondestructive Tests on Damaged Columns Strengthened with GFRP Jacketing
Authors: Gunarani G. I. , Karthikeyan B. , Priyadharshini A. , Selvaraj Senthil Kumaran , Jose S , Vincent Herald Wilson D. , Moges Adane Tezeta
Published: September 2022

This paper presents the experimental investigation of the load‐resisting characteristics of damaged columns repaired with glass reinforced polymer (GFRP) jacketing. The high‐strength columns were made with ground granulated blast furnace slag (GGBS) used at 15%, 25%, and 35% as a partial substitute for cement. Cube specimens of size 100 mm × 100 mm × 100 mm and columns of size 600 mm × 120 mm were cast to perform the study. Considering the practical difficulties in the construction field in obtaining river sand, industrial sand was used for making the specimens eco‐friendly. On completion of the prescribed curing period of 28 days, the cube specimens were subjected to a compression test to ensure the grade of the mix design, and the column specimens were subjected to axial loading and were tested in two categories, with and without wrapping of GFRP sheets’ split tensile strength. Compression tests on cubes and columns were done. The nondestructive test was also performed with the ultrasonic pulse velocity (UPV) method to check the dense nature of the concrete before and after wrapping with GFRP. On comparing the results, it was observed that it is possible to obtain a higher strength using industrial sand when supported with suitable admixtures and strengthening processes.
PARP-1 Is a Potential Marker of Retinal Photooxidation and a Key Signal Regulator in Retinal Light Injury
Authors: Li Xun , Zhang ZiYuan , Fan Bin , Li YuLin , Song DeJuan , Li Guang-Yu
Published: September 2022

Advancements in technology have resulted in increasing concerns over the safety of eye exposure to light illumination, since prolonged exposure to intensive visible light, especially to short-wavelength light in the visible spectrum, can cause photochemical damage to the retina through a photooxidation-triggered cascade reaction. Poly(ADP-ribose) polymerase-1 (PARP-1) is the ribozyme responsible for repairing DNA damage. When damage to DNA occurs, including nicks and breaks, PARP-1 is rapidly activated, synthesizing a large amount of PAR and recruiting other nuclear factors to repair the damaged DNA. However, retinal photochemical damage may lead to the overactivation of PARP-1, triggering PARP-dependent cell death, including parthanatos, necroptosis, and autophagy. In this review, we retrieved targeted articles with the keywords such as “PARP-1,” “photoreceptor,” “retinal light damage,” and “photooxidation” from databases and summarized the molecular mechanisms involved in retinal photooxidation, PARP activation, and DNA repair to clarify the key regulatory role of PARP-1 in retinal light injury and to determine whether PARP-1 may be a potential marker in response to retinal photooxidation. The highly sensitive detection of PARP-1 activity may facilitate early evaluation of the effects of light on the retina, which will provide an evidentiary basis for the future assessment of the safety of light illumination from optoelectronic products and medical devices.
Practical Research on College English Teaching Mode Reform Based on Computer Multimedia
Authors: Yang Zhao
Published: September 2022

The fastest development of technologies encourages computer multimedia-oriented education. Nowadays, information technologies create human basic abilities. College English teaching mode reform based on computer multimedia is the aim of the paper. Generally, computer multimedia technologies oriented college English education merging pictures, videos, audio, vocabulary, and animation. We described the development of multimedia in English teaching mode, applications of college English teaching, a novel model of foreign language teaching in the classroom and a computer, computerized English language teaching method TPACK design, and the latest architecture of college English language teaching based on computers in this paper. We are discussing face-to-face teaching, language lab autonomous learning room, network teaching area in multimedia, and network teaching circumstances in this paper. This paper evaluated wireless communication’s range, challenges facing college English teaching, comparative analysis of attitude, comparative analysis of curriculum, and comparative analysis of technology. We express that, from the year 2000 to the present, the technologies in wireless communications with computer multimedia are developing in the range of wireless communication.
Cryptography-Based Medical Signal Securing Using Improved Variation Mode Decomposition with Machine Learning Techniques
Authors: Shukla Piyush , Akanbi Oluwatobi , Atuah Asakipaam Simon , Aljaedi Amer , Bouye Mohamed , Sharma Shakti
Published: September 2022

There is no question about the value that digital signal processing brings to the area of biomedical research. DSP processors are used to sample and process the analog inputs that are received from a human organ. These inputs come from the organ itself. DSP processors, because of their multidimensional data processing nature, are the electrical components that take up the greatest space and use the most power. In this age of digital technology and electronic gizmos, portable biomedical devices represent an essential step forward in technological advancement. Electrocardiogram (ECG) units are among the most common types of biomedical equipment, and their functions are absolutely necessary to the process of saving human life. In the latter part of the 1990s, portable electrocardiogram (ECG) devices began to appear on the market, and research into their signal processing and electronics design capabilities continues today. System-on-chip (SoC) design refers to the process through which the separate computing components of a DSP unit are combined onto a single chip in order to achieve greater power and space efficiency. In the design of biomedical DSP devices, this body of research presents a number of different solutions for reducing power consumption and space requirements. Using serial or parallel data buses, which are often the region that consumes the most power, it is possible to send data between the system-on-chip (SoC) and other components. To cut down on the number of needless switching operations that take place during data transmission, a hybrid solution that makes use of the shift invert bus encoding scheme has been developed. Using a phase-encoded shift invert bus encoding approach, which embeds the two-bit indication lines into a single-bit encoded line, is one way to solve the issue of having two distinct indicator bits. This method reduces the problem. The PESHINV approach is compared to the SHINV method that already exists, and the comparison reveals that the suggested PESHINV method reduces the total power consumption of the encoding circuit by around 30 percent. The computing unit of the DSP processor is the target of further optimization efforts. Virtually, all signal processing methods need memory and multiplier circuits to function properly.
Tennis Video Target Tracking Based on Mobile Network Communication and Machine Learning Algorithm
Authors: Meng Fanming
Published: September 2022

The application of information technology has realized the transformation of people’s production and lifestyle and also promoted the development of the sports industry. At present, the application of informatization in the field of sports is becoming more and more powerful. By using the advanced methods and technologies of its information display, this paper aimed to realize the research on the tracking of tennis sports video objects in the mobile network environment. It is helpful to analyze and solve the objectivity problems such as most of the loopholes in the single research and traditional methods of tennis video target tracking research. By drawing on the principles and rules of machine learning algorithms, the tennis video target tracking research is carried out, and the informatization and dataization of tennis are realized. In the experiment of the target tracking algorithm, 12 tracking videos have higher tracking accuracy than other parameters. The overall tracking accuracy of the video sequence under grayscale feature was 0.694; the tracking accuracy was the highest, but the tracking speed was the lowest compared to other parameters in the experiment. Therefore, it is very important to study the target tracking of tennis sports in the tennis field.
Serum Sclerostin and Its Association with Bone Turnover Marker in Metabolic Bone Diseases
Authors: Chen Lihui , Gao Gao , Shen Li , Yue Hua , Zhang Ge , Zhang Zhenlin
Published: September 2022

Sclerostin is a secreted inhibitor of Wnt/β-catenin signaling that is mainly produced by osteocytes and is an important regulator of bone remodeling. Some studies have evaluated serum sclerostin levels in metabolic bone diseases, but the results have been contradictory. The profile of serum sclerostin levels in patients with osteogenesis imperfecta (OI), X-linked hypophosphatemia (XLH), and Paget’s disease of bone (PDB) was obtained to determine their association with bone turnover marker. Serum sclerostin levels, biochemical parameters, and the bone turnover marker, β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (β-CTX), were measured in 278 individuals, comprising 71 patients with OI, 51 patients with XLH, 17 patients with PDB, and 139 age- and sex-matched healthy controls. A correlation analysis was performed between sclerostin and β-CTX concentration. The univariate logistic regression analysis was used to analyze factors associated with OI, XLH, and PDB. Patients with PDB (11 male 6 female), aged

44.47
±
14.75

years; XLH (17 male, 34 female), aged

19.29
±
15.65

years; and OI (43 male, 28 female),

aged
 
19.57
±
16.45

years, had higher sclerostin level than age- and sex-matched healthy controls [median(interquartile range): 291.60 (153.42, 357.35) vs. 38.00 (27.06, 68.52) pmol/L, 163.40 (125.10, 238.20) vs. 31.13 (20.37, 45.84) pmol/L, and 130.50 (96.12, 160.80) vs. 119.00 (98.89, 194.80) pmol/L, respectively;

P
<
0.001

]. Patients with PDB had the highest level of serum sclerostin, followed by those with XLH and OI (

P
<
0.05

). Sclerostin was positively correlated with β-CTX in OI and XLH (

r
=
0.541

and

r
=
0.661

, respectively;

P
<
0.001

). Higher β-CTX and sclerostin levels were associated with a higher risk of OI, XLH, and PBD. Sclerostin may be a biomarker of OI, XLH, and PDB. Whether sclerostin inhibitors can be used in these patients requires further analysis using additional cohorts.
Application of Optical Fiber Sensing Technology in Permeability Test of Three-Dimensional Physical Model of Medium and Long-Distance Diversion Tunnel
Authors: Xu Zhijing , Zhang Guanghui , Chen Xiaoming , Yao Liangxue , Chen Guangyao , Wang Fei
Published: September 2022

In order to accurately simulate the dynamic change law of seepage field during construction, this paper proposes the application of optical fiber sensing technology in the permeability test of three-dimensional physical model of medium and long-distance headrace tunnel. This paper introduces the principle of optical fiber sensing, analyzes and compares the application advantages of optical fiber and general electrical signal sensing in the safety monitoring of long-distance diversion tunnel. Taking the safety monitoring of a 16# long tunnel of a diversion project as an example, the selection of monitoring sections, monitoring items, and the layout and networking of monitoring instruments are studied. In addition, combined with the tunnel project, the physical simulation of the construction process of the deep buried headrace tunnel under high seepage pressure is carried out, and the water pressure automatic control water supply system and the discrete flower tube seepage generation system are designed and manufactured to realize the high simulation of the seepage field. The seepage and evolution law in the surrounding rock of headrace tunnel during dynamic construction are calculated and analyzed. The test results show that the maximum external water pressure of the headrace tunnel is 15 MPa, which is equivalent to 1500 m head pressure, and the similar scale of head pressure is 100. Therefore, taking 15 m constant head water supply pressure for simulation calculation, the excavation of the tunnel is 120 cm, and the two-dimensional seepage of the vertical section of

Z
=
91
 
cm

. The seepage flow of the two sides of the tunnel is large, and the contour of the hydraulic gradient is dense. The coordinates are 0.7 m, 2.090 m, and 0.9 m. This point in the original rock mass is located at the same elevation point of the four headrace tunnels and directly below the model exploratory tunnel. The head pressure is 1.40 m, and the corresponding prototype point pressure head is 140 M. During construction, such a high external water pressure is a great safety hazard. Conclusion. The test conclusion provides a theoretical basis for the seepage prevention construction technology design of the headrace tunnel and is of great significance to the long-term stability, safety evaluation, and prediction of the headrace tunnel.
Differential Privacy via Haar Wavelet Transform and Gaussian Mechanism for Range Query
Authors: Chen Dong , Li Yanjuan , Chen Jiaquan , Bi Hongbo , Ding Xiajun
Published: September 2022

Range query is the hot topic of the privacy-preserving data publishing. To preserve privacy, the large range query means more accumulate noise will be injected into the input data. This study presents a research on differential privacy for range query via Haar wavelet transform and Gaussian mechanism. First, the noise injected into the input data via Laplace mechanism is analyzed, and we conclude that it is difficult to judge the level of privacy protection based on the Haar wavelet transform and Laplace mechanism for range query because the sum of independent random Laplace variables is not a variable of a Laplace distribution. Second, the method of injecting noise into Haar wavelet coefficients via Gaussian mechanism is proposed in this study. Finally, the maximum variance for any range query under the framework of Haar wavelet transform and Gaussian mechanism is given. The analysis shows that using Haar wavelet transform and Gaussian mechanism, we can preserve the differential privacy for each input data and any range query, and the variance of noise is far less than that just using the Gaussian mechanism. In an experimental study on the dataset age extracted from IPUM’s census data of the United States, we confirm that the proposed mechanism has much smaller maximum variance of noises than the Gaussian mechanism for range-count queries.
Ontology-Based Resource Modeling and Matching Framework in Avionics Systems
Authors: Du Xiaoyan , Du Chenglie , Chen Jinchao , Dong Chunhui , Liu Yifan
Published: September 2022

In order to realize rapid service-oriented construction of resources and efficient supply-demand matching in avionics systems, an ontology-based resource modeling and matching framework in avionics systems is proposed. First, this paper constructs a hierarchical resource organization framework based on virtual resource pool, covering dispersed and heterogeneous avionics resources and shielding the differences and diversity of resources; next, introduces ontology technology into resource modeling and encapsulates resources as services using the idea of “resource as a service,” facilitating the access and control of resources; in addition, proposes a matching framework which takes into account the energy consumption, in which it firstly tries to find a list of resources which can meet task requirements by a stepwise intelligent matching strategy based on semantic similarity, and the resources in the list will then be sorted according to the energy consumption. Finally, a radar detection case is taken to demonstrate that the proposed model and method are feasible and effective.
Estimation of Critical Safety Thickness of the Base against Confined Water Inrush for a Rectangular Foundation Pit
Authors: Li Qin-xing , Wang Hong-tao , Men Yan-qing , Yu Xiao , Liu Chi , Zhang Hua-jun
Published: September 2022

Affected by confined aquifer, basal inrush accidents caused by excavation are common in foundation pits, and accurate estimation of the safety thickness of the base is a big concern of engineers. In this paper, a three‐dimensional failure mechanism of base inrush was constructed for a rectangular foundation pit. In this mechanism, the strength of the soil mass was assumed to be nonhomogeneous along the depth, and the soil‐mass failure satisfied the linear and nonlinear Mohr–Coulomb strength criteria. Then, based on the limit equilibrium theory, the prediction method for the safety thickness of the base against confined water inrush was deduced, and a comparison with existing research works was conducted. Furthermore, the influence laws of soil strength parameters, pit design parameters, and confined water pressure on the critical safety thickness were analyzed. The results show that the critical safety thickness of the base is positively correlated with nonlinear coefficient and confined water pressure but negatively correlated with cohesion, internal friction angle, nonhomogeneity coefficient, and unit weight. The soil strength is a key factor affecting the base safety thickness, which should be paid enough attention to in engineering design and construction. The research findings in this paper can provide a theoretical reference for the prevention and control of basal inrush accidents in confined water strata.
Utilization of Biang Fish Flour (Ilisha elongata) as an Enrichment Material for Sago Noodles Nutrient Value
Authors: Suparmi Suparmi , Sumarto Sumarto , Afriana Umi , Hidayat Taufik
Published: September 2022

This study aims to determine the appropriate concentration of lead fish meal for enriching the nutritional value of sago noodles favored by consumers. The method used is an experimental design using Completely Randomized (CRD) with 4 concentration levels of lead fish meal, namely, 4% without a lead fish meal (M0), 6% (M1), 8% (M2), and 10% (M3). The analysis of sago noodles was performed and proximate by the AOAC method; amino acids by HPLC; fatty acids by GC; and minerals by HPLC. The results of the showed that the study getting the best treatment was a concentration of 8% (M2) with the characteristics of whole sago noodles’ appearance: attractive, grayish-white color; a distinctive aroma of sago noodles with a hint of fish; a specific taste typical of sago noodles and fish prickly taste; delicious; slightly chewy texture. Sensory evaluation with a taste value of 8.9, an aroma of 8.6, a visual value of 8.9, and a texture value of 8.8. Its nutritional content is 5.58% protein content, air 22.35%, ash 1.69%, fat 1.41%, and carbohydrates 68.29%. The proximate values are protein 5.58%, water content 22.35%, ash 1.69%, fat content 1.41%, and carbohydrates (different) 68.29%. The mineral content is Ca.P.I, Mg, Zn, and Fe. Amino acids consist of 8 types of essential amino acids, namely, histidine, arginine, threonine, valine, alanine, methionine, isoleucine, leucine, phenylalanine, and 7 types of nonessential amino acids, namely, aspartic acid, glutamic acid, serine, glycine, tyrosine. Its fatty acid profile has 13 components of unsaturated fatty acids and 17 components of saturated fatty acids.
MEC-Based Cooperative Multimedia Caching Mechanism for the Internet of Vehicles
Authors: Han Longzhe , Li Sheng , Ao Chenchen , Liu Yan , Liu Guangming , Zhang Yiying , Zhao Jia
Published: September 2022

Multimedia applications are expected to widely deploy over vehicular networks. In order to meet the low-latency and high-speed transmission requirements of multimedia applications, edge caching is introduced to reduce the network traffic and the transmission delay. Due to the limited storage of the edge cache server, an efficient approach for the content management plays a decisive role for the edge cache performance. This paper proposes a vehicle-to-infrastructure-based cooperative caching mechanism for Internet of Vehicles to improve the edge cache utilization. The system model is established with the goal of maximizing the cooperative caching hit rate. To jointly consider the collaborations between macrobase stations (MBS) and multiple roadside units (RSU), we propose a reinforcement learning algorithm to adaptively control the cache management. According to the content popularity and the network status, the proposed algorithm can dynamically adjust cached content across relevant MBSs and RSUs. The simulation results show that the proposed cooperative caching mechanism significantly improve the cache utilization and the quality of services.
[Retracted] Dance Action Recognition Model Using Deep Learning Network in Streaming Media Environment
Authors: Yan Ming , He Zhe
Published: September 2022

Dance movement recognition is a video technology that has a significant impact on intelligent applications and is widely applied in many industries. In the training of intelligent dance assistants, this method can be used. Dancers’ postures can be reconstructed by taking the features out of their images. Examine and correct dancers’ postures in order to recognise their dance movements. The most crucial aspect of this technology is effectively extracting features, and deep learning is currently one of the best ways to do this for video features. In this paper, the dance movement recognition method is studied using a convolution neural network based on a deep learning network. The deep‐learning‐network‐based convolution neural network is also used to conduct a simulation test, confirming the viability of this method for the recognition of dance movements. Due to the addition of manually extracted time‐domain optical flow information, the convolution neural network’s accuracy in recognising dance movements has increased by 30.65% and 19.49% for InceptionV3 and 3D‐CNN networks, respectively. It is evident from this that the convolution neural network suggested in this paper is more effective at identifying dance movements. Dance movements will continue to develop quickly thanks to the improvement of the in‐depth recognition system for them. This technology has a wide range of applications in the instruction and practise of dance movements, and this research has promising application potential.
Smart Garage Utilizing Internet of Things (IoT)
Authors: Torad Mohamed A. , Bouallegue Belgacem , Khattab Mahmoud M. , Ahmed Abdelmoty M.
Published: September 2022

People in urban regions face a daily problem finding parking slot for their vehicles. So, this study develops a network architecture based on Internet of Things platform. A system improves the efficiency of the current cloud-based smart-parking system. This study suggested a system that assists users in automatically finding a free parking space at the lowest cost. With an application, a user can request to reserve a parking slot. The application moves a driver directly into the free slot in a garage. Also, it utilizes the distance and total number of free spaces in each garage to determine the user nearest parking slot and cost. The garage slot cost will be charged by user credit once the user entered the garage or reserved a parking slot through the application. The system proposed a novel system which picks up a parking slot, reserves, and pays for it through mobile application. The proposed system can easily be deployed in the actual world.
Visual Sensor Image Deconstruction in Constructing Green Building Design Space Adjustment Construction Strategy
Authors: Xia Xiumin
Published: September 2022

Since the introduction of green design in China, the space adjustment of green building design has received great attention from architects. Because space adjustment is very important for the pre-construction of a green building, it also represents the effectiveness of the building after its operation. At the same time, the spatial adjustment of green buildings is also a professional level test for architects. In order to obtain more accurate information about various aspects of the building, it is not enough to rely on the naked eye or measuring tools. Because it is impossible to comprehensively inspect the entire building, and the data is too cluttered, it is inconvenient to carry out a one-step construction strategy. Therefore, this study proposes to use visual sensors to analyze the image of a building, so as to achieve the data effect that architects want and to achieve the best effect in space adjustment. In order to prove the applicability of visual sensors, this study takes the current situation of domestic green building projects as a case study and deeply explores the status of domestic green building projects under the current social background. Then, the method of the visual sensor is used to analyze the problem of building space adjustment, and experimental research on the performance of this technology is carried out. The results show that this technology is very suitable for the study of construction strategies for spatial adjustment. In building identification, the error of the algorithm in this study in the measurement range of 1 m to 2 m is obviously smaller than that of other methods, and the accuracy is basically kept within 1 cm. Therefore, in order to better develop the green design, we should focus on the application of visual sensors in this regard.
Integrability, Variational Principle, Bifurcation, and New Wave Solutions for the Ivancevic Option Pricing Model
Authors: Elmandouh A. A. , Elbrolosy M. E.
Published: September 2022

The Ivancevic option pricing model comes as an alternative to the Black‐Scholes model and depicts a controlled Brownian motion associated with the nonlinear Schrodinger equation. The applicability and practicality of this model have been studied by many researchers, but the analytical approach has been virtually absent from the literature. This study intends to examine some dynamic features of this model. By using the well‐known ARS algorithm, it is demonstrated that this model is not integrable in the Painlevé sense. He’s variational method is utilized to create new abundant solutions, which contain the bright soliton, bright‐like soliton, kinky‐bright soliton, and periodic solution. The bifurcation theory is applied to investigate the phase portrait and to study some dynamical behavior of this model. Furthermore, we introduce a classification of the wave solutions into periodic, super periodic, kink, and solitary solutions according to the type of the phase plane orbits. Some 3D‐graphical representations of some of the obtained solutions are displayed. The influence of the model’s parameters on the obtained wave solutions is discussed and clarified graphically.
Guidance for Administering Biologics for Severe Asthma and Allergic Conditions
Authors: Dorscheid Delbert R. , Lee Jason K. , Ramesh Warren , Greenwald Mark , Del Carpio Jaime
Published: September 2022

Asthma is a common respiratory disorder in Canada for which biologics may be prescribed for poorly controlled illness. Treatment with biologics, however, is sometimes inappropriately discontinued due to misconceptions regarding their potential immunologic effects, and concerns surrounding their continued use in severe asthma during the COVID-19 pandemic continue to propagate. Biologics can still be administered in a majority of health and treatment conditions. With regard to cardiac-related issues such as hypertension or cardiovascular disease (CVD), there is no solid evidence that suggests biologics should be withheld, as the benefits of treatment outweigh the risks. Asthmatic patients on biologic treatment should also continue treatment if they have, or are currently being treated for, a respiratory infection, including COVID-19. Evidence also indicates the importance of maintaining asthma control to reduce the risk of severe COVID-19 infection. Biologic treatment can be administered in severe asthmatic patients with bronchiectasis, though further evidence is needed to better understand the benefits. Biologic treatment should be continued postsurgery to reduce postoperative respiratory complications, as well as throughout the course of pregnancy. Regarding concerns over vaccine administration, nearly all vaccines can be given without interruption of biologic treatment in patients with severe asthma or allergic conditions. Appropriate screening for respiratory illnesses, such as COVID-19, continues to be warranted in clinical practices to reduce the risk of transmission. As recommendations from public health and regulatory agencies have been lacking, this guidance document addresses the administration of biologics in different health circumstances and respiratory illness screening during the COVID-19 pandemic.
Model Test of TBM Tunnel Crossing Large Dip Angle Fault Zone under High In Situ Stress
Authors: Wang Liming , Hong Kairong , Quan Yongwei , Zhao Hailei , Zhao Xiangbo , Yang Zhenxing , Zhou Zhenliang
Published: September 2022

In order to study the effect of fracture zone on tunnel stability under high ground stress and to reveal the disaster mechanism of fracture zone surrounding rock compressor, the TBM tunnel of Fragrant Furnace Mountain Tunnel in the F12 fracture zone in Dali I section of central Yunnan was experimentally studied. The results show that the TBM cutter head has a significant effect on the surrounding rock pressure in the range of 0.43 D~0.5 D (hole diameter), with a maximum increase of 1.19-fold. As the measurement point approaches the tunnel contour, the displacement of surrounding rock increases. As TBM traverses the fracture zone interface, the displacement of surrounding rock increases at the maximum rate. The effect of TBM shear rock formation failure on the internal displacement of rock formation is 1.21 D in the front and not more than 1.5 D in the top. Sliding and loosening of the fault zone looser above the interface can easily lead to blockage of the fault zone, and the pressure of the surrounding rocks at front edge does not affect more than 1.73 H (the length of horizontal projection of the fault zone interface). Therefore, in the course of construction, the interface of fracture zone should be promoted to reduce the construction risks.
Activated Hepatic Stellate Cells Promote the M1 to M2 Macrophage Transformation and Liver Fibrosis by Elevating the Histone Acetylation Level
Authors: Chen Junru , Huang Xueqing , Huang Zhi , Cao Yu
Published: September 2022

Liver fibrosis results from the formation of fibrous scars of hepatic stellate cells by various chronic liver diseases. Considering that the liver is the most important metabolic organ in the human body, exploring the metabolic characteristics of liver fibrosis is expected to discover new markers and therapeutic targets. In this study, we first used mouse model to verify that both lactate content and histone acetylation levels were significantly increased in hepatic fibrosis mice. At the same time, it was confirmed that activated hepatic stellate cells (HSCs) cocultured with M1 macrophages can promote their transformation into M2 macrophages in hepatic stellate cell line and primary hepatic stellate cells. In addition, the addition of lactic acid to the medium in which M1 cells are cultured can promote their transformation into M2 macrophages. Therefore, we concluded that activated HSCs can promote the transformation of M1 to M2 macrophages through lactate accumulation, thereby causing liver fibrosis.
Oral Cancer Risk Assessment for Different Types of Smokeless Tobacco Products Sold Worldwide: A Review of Reviews and Meta-analyses
Authors: Gupta Alpana K. , Kanaan Mona , Siddiqi Kamran , Sinha Dhirendra N. , Mehrotra Ravi
Published: September 2022

Smokeless tobacco (SLT) use is a significant cause of lip and oral cavity cancers. Globally, oral cancer prevalence is strongly linked to the types of tobacco products used, their chemical composition, and their pattern of use. Except snus, all SLT products sold in different World Health Organization regions are strongly associated with oral cancer incidence. Shammah showed the highest association OR with 95% confidence intervals (CI; OR, 38.74; 95% CI, 19.50–76.96), followed by oral snuff (OR, 11.80; 95% CI, 8.45–16.49), gutkha (OR, 8.67; 95% CI, 3.59–20.93), tobacco with betel quid (OR, 7.74; 95% CI, 5.38–11.13), toombak (OR, 4.72; 95% CI, 2.88–7.73), and unspecified chewing tobacco (OR, 4.72; 95% CI, 3.13–7.11). Most SLT products containing high levels of carcinogenic tobacco-specific nitrosamines (TSNA) exhibit a high risk of oral cancer. There is an urgent need to frame and implement international policies for oral cancer prevention through legal control of the TSNA levels in all SLT product types.

Prevention Relevance:

Most smokeless tobacco products sold worldwide, mainly shammah, toombak, gutkha, betel quid with tobacco, and dry snuff, are associated with a high risk of oral cancer. A high concentration of tobacco-specific nitrosamines in smokeless tobacco products is the major causative factor for oral cancer development.
Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex
Authors: Devall Matthew A.M. , Dampier Christopher H. , Eaton Stephen , Ali Mourad Wagdy , Plummer Sarah J. , Bryant Jennifer , Gauderman W. James , Peters Ulrike , Powell Steven M. , Casey Graham
Published: September 2022

Observational studies indicate that calcium supplementation may protect against colorectal cancer. Stratified analyses suggest that this protective effect may differ based on anatomic subsite and sex, but these hypotheses have been difficult to test experimentally. Here, we exposed 36 patient-derived organoid lines derived from normal colon biopsies (21 right colons, 15 left colons) of unrelated subjects (18 female, 18 male) to moderate (1.66 mmol/L) or high (5.0 mmol/L) concentrations of calcium for 72 hours. We performed bulk RNA-sequencing to measure gene expression, and cell composition was inferred using single-cell deconvolution in CIBERSORTx. We tested for significant differences in gene expression using generalized linear models in DESeq2. Exposure to higher levels of calcium was associated with changes in cell composition (P < 0.05), most notably increased goblet and reduced stem cell populations, and differential expression of 485 genes (FDR < 0.05). We found that 40 of these differentially expressed genes mapped to genomic loci identified through colorectal cancer genome-wide association studies, suggesting a potential biologic overlap between calcium supplementation and inherited colorectal cancer risk. Stratified analyses identified more differentially expressed genes in colon organoids derived from right sided colon and male subjects than those derived from left sided colon and female subjects. We confirmed the presence of a stronger right-sided effect for one of these genes, HSD17B2 using qPCR in a subset of matched right and left colon organoids (n = 4). By relating our findings to genetic data, we provide new insights into how nutritional and genetic factors may interact to influence colorectal cancer risk.

Prevention Relevance:

A chemopreventive role for calcium in colorectal cancer is still unclear. Here, we identify mechanisms through which calcium supplementation may reduce risk. Calcium supplementation increased differentiation and altered expression of colorectal cancer-related genes in a large study of patient-derived colon organoids. These findings were influenced by colon location and sex.
Megalin-Mediated Endocytosis in the Kidney Proximal Tubule: Relevance to Regulation of the Renal Renin-Angiotensin System
Authors: Hummelgaard Sandra , Weyer Kathrin
Published: September 2022

The kidney proximal tubule is a major target tissue of the renin-angiotensin system (RAS). Megalin is an endocytic multiligand receptor abundantly expressed in the proximal tubule where it drives reabsorption of peptides and proteins from the glomerular ultrafiltrate. All major RAS components are present in the kidney proximal tubules. Here, megalin drives endocytosis of angiotensinogen (AGT), prorenin, and renin, while angiotensin-converting enzyme is localised at the brush border of the proximal tubule cells. Intrarenal formation of the key RAS effector angiotensin II (ANG II) occurs, and liver-derived AGT appears to be the primary source. New studies further suggest that megalin-mediated reabsorption of liver-derived AGT contributes to renal ANG II levels and thereby may influence renal RAS activity. This mini-review presents the recent advances on RAS in the proximal tubule and the involvement of megalin in the uptake and regulation of local RAS and discusses the possibility that megalin is involved in blood pressure regulation.
Breastfeeding and Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Holz Anja , Riefflin Maya , Heesen Christoph , Riemann-Lorenz Karin , Obi Nadia , Becher Heiko
Published: September 2022

Introduction: The causes of multiple sclerosis (MS) are not fully understood, yet. Genetic predisposition, environmental and lifestyle factors as well as an interplay thereof constitute relevant factors in the development of MS. Especially early-life risk factors such as having been breastfed may also be of relevance. Breast milk provides the newborn not only with essential nutrients and vitamins but also with numerous immune-active molecules, metabolites, oligosaccharides, and microbial components that are important for the development of the immune system. We present a systematic review and meta-analysis on the influence of having been breastfed during infancy on the risk of developing MS. Methods: The databases MEDLINE, Cochrane Library, and Web of Science were systematically searched for studies on breastfeeding and MS published between database inception and May 18, 2022. Observational studies comparing persons with MS to healthy controls with regard to having been breastfed during the first 2 years of life were eligible for inclusion. A random effects meta-analysis was calculated to estimate pooled effect sizes using the Mantel-Haenszel method for dichotomous outcomes. The Newcastle-Ottawa Scale was used for quality analysis. Results: 15 studies (13 case-control, 2 cohort) were included of which 12 were rated as high quality. The meta-analysis of crude odds ratios (ORs) yielded a risk estimate of ORcrude = 0.82 (95% confidence interval [CI]: 0.70–0.96) for MS in breastfed versus non-breastfed individuals with substantial heterogeneity (I2 = 68.2%). Using adjusted OR, when available, reduced heterogeneity (I2 = 48.9%) and resulted in an ORadjusted = 0.86 (95% CI: 0.75–0.99). Restricting the analysis to studies with high-quality scores (i.e., ≥6/9 points) resulted in a combined ORcrude of 0.79 (95% CI: 0.66–0.94) and an ORadjusted = 0.83 (95% CI: 0.71–0.98), respectively. Discussion/Conclusion: The meta-analysis showed a small protective effect of having been breastfed on MS risk. This adds to the knowledge that breastfeeding is beneficial for the immunological health of a child. Future studies on the influence of having been breastfed on MS risk should apply a uniform definition of breastfeeding and investigate possible sex-specific aspects.