Green tea and coffee consumption and risk of kidney cancer in Japanese adults
Authors: Chen Yichi , Abe Sarah K. , Inoue Manami , Yamaji Taiki , Iwasaki Motoki , Nomura Shuhei , Hashizume Masahiro , Tsugane Shoichiro , Sawada Norie ,   the JPHC Study Group,   Members of the Japan Public Health Center-based Prospective Study in 2021, Sawada N. , Tsugane S. , Iwasaki M. , Inoue M. , Yamaji T. , Katagiri R. , Miyamoto Y. , Ihira H. , Abe S. K. , Tanaka S. , moriya T. , Minamizono T. , Shirai Y. , Kuniyoshi H. , Yoshimi T. , Sonoda H. , Tagami T. , Ando T. , Kimura T. , Kokubo Y. , Yamagishi K. , Mizoue T. , Nakamura K. , Takachi R. , Ishihara J. , Iso H. , Kitamura T. , Saito I. , Yasuda N. , Mimura M. , Sakata K. , Noda M. , Goto A. , Yatsuya H. , Mimura M. ,   Past members, Hanaoka T. , Hidaka A. , Sasazuki S. , Charvat H. , Shimazu T. , Budhathoki S. , Muto M. , Imatoh T. , Ogata J. , Baba S. , Mannami T. , Okayama A. , Miyakawa K. , Saito F. , Koizumi A. , Sano Y. , Hashimoto I. , Ikuta T. , Tanaba Y. , Sato H. , Roppongi Y. , Takashima T. , Suzuki H. , Sugie T. , Miyajima Y. , Suzuki N. , Nagasawa S. , Furusugi Y. , Nagai N. , Ito Y. , Komatsu S. , Sanada H. , Hatayama Y. , Kobayashi F. , Uchino H. , Shirai Y. , Kondo T. , Sasaki R. , Watanabe Y. , Miyagawa Y. , Kobayashi Y. , Machida M. , Kobayashi K. , Tsukada M. , Kishimoto Y. , Takara E. , Fukuyama T. , Kinjo M. , Irei M. , Sakiyama H. , Sakiyama H. , Imoto K. , Yazawa H. , Seo T. , Seiko A. , Ito F. , Shoji F. , Saito R. , Murata A. , Minato K. , Motegi K. , Fujieda T. , Yamato S. , Matsui K. , Abe T. , Katagiri M. , Suzuki M. , Doi M. , Terao A. , Ishikawa Y. , Sueta H. , Doi H. , Urata M. , Okamoto N. , Ide F. , Goto H. , Fujita R. , Sou Y. , Sakiyama H. , Onga N. , Takaesu H. , Uehara M. , Nakasone T. , Yamakawa M. , Miyasato Y. , Horii F. , Asano I. , Yamaguchi H. , Aoki K. , Maruyama S. , Ichii M. , Takano M. , Tsubono Y. , Suzuki K. , Honda Y. , Sakurai S. , Tsuchiya N. , Kabuto M. , Yamaguchi M. , Matsumura Y. , Sasaki S. , Watanabe S. , Akabane M. , Kadowaki T. , Takashima Y. , Yoshida Y. , Matsushima S. , Natsukawa S. , Sugimura H. , Tominaga S. , Iida M. , Ajiki W. , Ioka A. , Sato S. , Konishi M. , Okada K. , Sobue T. , Kawaguchi Y. ,   Members of the committee for external evaluation in JPHC Study in 2021, Hamajima N. , Akiba S. , Isobe T. , Sato Y. , Sobue T. ,   Past members of the committee external evaluation, Shimizu H. , Kono S. , Sobue T. , Maruyama E. 
Published: November 2022

The study aimed to evaluate the association between green tea and coffee consumption and the risk of kidney cancer using data from a large prospective cohort study in Japan (the Japan Public Health Center-based Prospective Study: JPHC Study). A total of 102,463 participants aged 40–69 were followed during 1,916,421 person-years (mean follow-up period, 19 years). A total of 286 cases of kidney cancer (199 in men, 87 in women) were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) while adjusting for potential confounders. No statistically significant association between green tea intake and kidney cancer risk was found in the total population. Among women who consumed more than five cups of green tea per day, a statistically significant decreased risk was shown with a HR of 0.45 (95% CI: 0.23–0.89), compared to women who rarely consumed green tea. For coffee consumption, the association of kidney cancer risk was not statistically significant. This large prospective cohort study indicated green tea intake may be inversely associated with kidney cancer risk in Japanese adults, particularly in Japanese women.