bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advancements in Intrusion Detection in Software Defined Network Security
Authors: Shridhar R Sharma  , V. Mohan  , B K Madhavi  , S B Kishor
Published: April 2022

In recent years, Software Defined Networking (SDN) has enabled total control over the network's data flow. SDN acts as a centralised point of administration for data and traffic management. Due to the fact that SDN is an open source software, it is more vulnerable to security concerns. Security policies must also be adhered to, since this would expose the controller to the greatest attacks. DDOS and DOS assaults are more prevalent in SDN controllers. DDOS is a damaging assault that disrupts the usual flow of communication and initiates an overflow of flooded packets, thereby shutting down the system. Machine Learning approaches assist in identifying the network's hidden and unexpected patterns, hence aiding in the analysis of the network's flow. All classified and unclassified approaches can assist in detecting hostile flows depending on specific factors such as packet flow, time length, precision, and accuracy rate. To identify DDOS assaults, researchers employed Bayesian Networks, Wavelets, Support Vector Machines, and KNN. According to the review, KNN offers superior results due to its increased accuracy and reduced false positive rate for detection. We explore the various strategies used in DDoS detection and examine new improvements in intrusion detection in software defined networks in this article.
Logistic Regression Modeling for Maternal Determinants of Low Birth Weight
Authors: S. Sundarabalan  , S. Raguraman
Published: April 2022

Low birth weight is a major public health issue in India. Low birth weight leads to an impaired growth of the infant resulting in a higher mortality rate and increased morbidity. In India, nearly 20% of new borns have Low birth weight. Males have less frequency of Low birth weight than females. This study emphasizes the need for improving maternal health, weight gain during pregnancies, prevention and proper management of risk factors along with improving socioeconomic and educational status of mothers. Logistic regression is a statistical model for analyzing a dataset in which one or more independent variables that determine an outcome. The main objective of this paper is to identify the predictors of low birth weight through simple logistic regression model.
Review on MRR in Spark Erosion Machining (SEM) Through ANN
Authors: Rahul Shrinivasan  , Tushar Bhakte
Published: April 2022

EDM is a modern machining technology used to machine hard material pieces that are difficult to produce using traditional machining methods. This article aims to optimize process factors to obtain maximum MRR and high surface integrity in the end cut. Using artificial neural networks, this research proposes a technique for automatically determining and optimizing processing parameters in the EDM sinking process (ANN). The availability of machining data in the industrial tool room survey is the primary issue regarding adjusted process parameters for precision machining. Experiments are conducted to investigate the effect of pulse current, pulse on time, electrode area, and gap voltage on MRR response.
College Enquiry Chat Bot System with Text to Speech
Authors: Pratiksha Chaudhari  , Sonal Lokhande  , Vaishnavi Ghule  , Pruthviraj Kakade  , Aniket Surkamble  , Prof. Aparna Kulkarni
Published: April 2022

Chat bots are intelligent systems that interpret and react to users' questions in their native language. In a conversation, the chat bot reacts in the same way as a human would. It functions as a virtual assistant, and its accuracy is assessed by determining a correlation between user questions and chat bot responses. For a better user experience, the implemented Chat bot has two modes: text mode and audio mode. It provides an interactive approach of answering through voice messages when in audio mode. There is a long line at the inquiry window during the Institute's Academic Admission procedure. Even more challenging is the situation for parents who live in various cities, states, and nations. The purpose of this system is to give students and parents a place to ask questions and get answers via easy English language text messages or audio commands. Instead of queuing at an information desk to ask questions about the admissions process, students and parents will collaborate with a bot. Artificial intelligence (AI) and natural language processing (NLP) algorithms are used to create chatbots, which are intelligent systems. It effectively interacts with users and responds to their questions. Organizations, government groups, and non-profit associations are the most common users of dialogue/conversation operators. These conversational experts work for a wide range of businesses, from small start-ups to large corporations. There are a variety of code-based and interface-based chatbot development platforms available on the market.
Accelerate The Implementation of Village SDGs Through a Children-Worth Village
Authors: Fahrunnisa  , Ayuning Atmasari  , Lalu Ahmad Taubih  , Apriadi
Published: April 2022

The Government of Indonesia through Presidential Regulation Number 25 of 2021 concerning Child-friendly District/City Policies again emphasizes that districts/cities throughout Indonesia become KLA and the fulfillment of children's rights and special protection. Sumbawa Regency is one of the regencies in West Nusa Tengga Province that has been committed to realizing KLA since 2017. However, until now Sumbawa Regency has not been able to get the KLA predicate, either Nindya, Madya or Pratama. Through the initiation of the Child Friendly Poto Village, the local government together with the Samawa Center tried to implement a bottom-up approach in KLA. For this reason, this study aims to determine the design, implementation and initiation process of child-friendly villages in Poto Village, District, as well as the challenges and obstacles. This study uses a PAR approach based on the concept of rights-based community development popularized by Ife and Tesoriero (2000). The result of this research is that the design of the implementation of DLA is adjusted to the conditions of the local community where it begins with the common perception and preparation of the DLA action plan. The challenges and obstacles lie in the commitment of the members of the task force and the village government. This is because the DLA issue is still considered new and not very familiar so that understanding is not yet complete.
Environment Feature and Obstacle Position Prediction Using Long Short-Term Memory
Authors: Samir N. Ajani  , Salim Y. Amdani
Published: April 2022

Congestion management and procedural knowledge require obstacle prediction of network based on large amounts of dataset. Traditional time series forecasting approaches struggle to create effective prediction models since time series analysis in prediction of network traffic is very unstable time parameter and is also non linear in nature, which may cause a very low forecast accuracy. Hence the define usage of LSTM ie. Long Short Term Memory Recurrent Neural Network has been developed as very important alternative for Neural Network (NN) efficiency. The paper proposed to develop an efficient method in combination with genetic algorithm (GA) and of Long Short Term Memory Recurrent Neural Network (LSTMs) in prediction of environment features and positions of obstacles. The combination of both will be comprises of two sections, one with LSTM which is used for feature extraction and GA is used to enhance hyper parameters extracted for the LSTMs networks. The method assumes the higher prediction accuracy as compared to previous research study with decrease in prediction of errors, with categorization of complex changes with considered data; this is done by comparing the ARIMA i.e. Auto Regressive Integrated Moving Average and LSMTs.
Microgrid Power Quality Improvement Using Active Power Conditioner
Authors: Amit M. Sirsat  , Dr. Swapnil B. Mohod  , Dr. Mohan B. Tasare
Published: April 2022

This paper discusses power system power quality issues and possible remedies using power electronics. Several worldwide standards This research shows how a Shunt active power filter can improve power quality in a microgrid system at the distribution level. The major goal of this study is to find an appropriate pulse generating strategy for improving the shunt active power filter's compensation capabilities. The device's compensating capability is mostly determined by the DC link capacitor voltage regulation. A fixed hysteresis current control approach has been employed in the past. An adaptive hysteresis current control technique has been developed here to improve the performance of a shunt active power filter. The suggested technique's performance has been verified in the MA TLAB/SIMULINK model platform under various operating conditions.
Geophysical Resistivity Survey (VES) for Selection of Artificial Recharge of Appropriate Artificial recharge for Augmentation of Ground Water Resources In Paithankheda Village, M. S. India
Authors: N. V. Sharma  , I. S. Shaikh
Published: April 2022

In this study the data generated while conducting electrical resistivity surveys through Vertical Electrical Sounding (VES) at 22 sites in different location along with a available geological &hydro-geological information of Paithan Kheda village were analyzed. The objective are (i)to understand the nature and extent of aquifer(ii)to find out the location and thickness of unsaturated zones and (iii)to evaluate and extent of appropriate artificial recharge structures at suitable locations across the village.
Interpretation of the top sounding curves indicates presence of three to four subsurface geo-electric layers across the study area. The top soil ;layer has range of resistivity values from 2 to 30-ohm m & litho logy comprise clay with kankar,lateritic sand. This is followed by the weathered and jointed Basalt layers with resistivity values 100
300-ohm m could be identified below the depth of 45m.At some places, doleritic dykes were also observed with resistivity values >300-ohms.
The interpretation of VES data when correlated with the available lithilog data indicates a prominent water bearing zone between 30 and 45 mbgl.The underlying hard and compact Basalt has very little possibility of occurrence of groundwater. The top unsaturated and unconfined granular zone up to adept of 30mts could therefore be easily recharged artificially through rainwater harvestining measures thereby augmenting the groundwater resources of the existing aquifers. Site specific artificial recharge measures from amongst counter banding ,gully plugs ,check dams, percolation tank. Recharge shafts subsurface dikes have been identified across the village for effective recharge of the aquifer especially in its north eastern &southern blockregions.Considering the deteeoriating groundwater sitution, these initiatives would be significant in catering the needs of future generations.
Study Of Salivary Glands Masses by Cytology and Confirmed by Histology : An Evaluation of Complication With FNAC
Authors: Dr. Nita Kumari
Published: April 2022

In this paper, we studied about the salivary glands masses by cytology and confirmed by histology, and an evaluation of complication with FNAC.
Study of Residence Time Distribution in Chemical Industry - A Review
Authors: Shivani Kaustubh Chitale  , Pranjal Nitin Jadhav  , Snehal Suresh Dhoble  , Dr. Mrs. Sonali Dhokpande  , Prashant Ingole
Published: April 2022

The concept of residence time distribution (RTD) is an important tool for the analysis of industrial units and reactors. The RTD of fluid flow in process equipment analyses their performance and checks the feasibility of a reactor. RTD method has been widely used in industry to optimize processes, solve problems, improve product quality, save energy, and reduce pollution. The technical, economic, and environmental benefits have been well understood and recognized by various sectors such as industrial and environmental sectors. The petrochemical industries, mineral processing, and wastewater treatment sectors are identified as the most appropriate target beneficiaries. This review traces current applications of the residence time theory in various chemical industries. Besides reviewing recent experimental studies in the literature, some common modeling, tracer injection and detection technique, and different parameters are studied to understand RTD.
An Analysis of the Influence of Family Cumulative Risks on Adolescents' Mental Health
Authors: Chen Ying
Published: April 2022

Family education is the foundation of a person's growth and development. When the risk factors in the family accumulate to a certain level, it is easy to have an adverse effect on the mental growth and personality formation of adolescents, and affect the mental health of adolescents. This article analyzes the influence of family cumulative risks on the growth and development of adolescents from varies angles, and based on the analysis, we propose corresponding family education methods, aiming to put forward certain guidelines for the advancement of current family education. That includes, attaching importance to children's mental health education, providing necessary dredging and counseling for children, promptly preventing and solving psychological problems, paying attention to children's learning and life problems, paying attention to teenagers' personality problems, and correctly handling family members' relationship.
“Why would anyone leave?”: Development, overindebtedness, and migration in Guatemala
Authors:   California State University, Long Beach, Heidbrink Lauren , Batz Giovanni , Sánchez Celeste ,   Loyola University, Chicago
Published: April 2022

Over the past two decades, policymakers have expressed considerable optimism about the capacity of international development to curb transnational migration, yet there is a dearth of research examining how and under what conditions development interventions impact migration decisions. Enlisting a case study approach in the Maya-K’iche’ community of Almolonga, this article examines divergent meanings and practices of “development” and its impact on the migratory aspirations and outcomes of Indigenous families in Guatemala. Government authorities and international development experts exalt Almolonga as a prosperous example of a globalized, agrarian-based economy. Key to its ‘success’ is the growing microcredit industry which advertises loans as a means to invest in small businesses and to enable household purchasing power. Yet, as our survey finds, this credit often cascades into over indebtedness, leading to significant out-migration. In contrast, local understandings of development arerooted in the K’iche’ concept of utz k'aslemal, a system of complementary economies and intergenerational knowledge-sharing through education and entrepreneurship in an effort to create pathways to ‘el buen vivir.’ By tracing the conflicting meanings assigned to development, we argue that over indebtedness resulting from microcredit not only reinforces but likewise exacerbates existing social inequalities in Guatemala and, contrary to development claims, induces migration.
Trends in language choice and effects of choice on acquisition: Kaqchikel Maya and Spanish in central Guatemala
Authors:   Temple University, Homquist Jonathan , Muzika Kahn Hana ,   Temple University
Published: April 2022

This study reveals trends in the choice of Kaqchikel Maya, Spanish, or both languages for household activities and by the generations, that is, the children, parents, and grandparents, in a village and a town in the central highlands of Guatemala. Similarities and differences between the village and town are described in both cases. The study also highlights the direct relationship between the language choice of parents and the acquisition of Kaqchikel by children. A total of 171 indigenous residents in the town and the village participated in the study. Findings are based on responses to a sociolinguistic questionnaire that also included measures of knowledge of Kaqchikel. Interviews were conducted by the authors working with bilingual Spanish and Kaqchikel Maya speaking assistants. The measures of knowledge of Kaqchikel were created by the bilingual assistants. The conclusion of this study includes discussion of limitations of current policies for promoting the Kaqchikel language through the education system and broadcasting media.
Utilização dos atuais métodos de agitação de soluções endodônticas no canal radicular
Authors: Schneider Lívia Rodrigues , Giovanella Larissa
Published: April 2022

Sabe-se atualmente que durante a instrumentação do canal radicular nem sempre todas as paredes entram em contato com os instrumentos endodônticos. Frente a isso, é de suma importância a utilização de substâncias irrigadoras para alcançar esses determinados locais. A agitação destas soluções permite que elas sejam mais efetivas e aumentem seu desempenho. Frente a esse cenário, o presente trabalho busca responder a seguinte questão norteadora: Qual instrumento promove a melhor agitação das soluções endodônticas? Com isso, o objetivo geral do presente estudo foi realizar uma revisão de literatura, discorrendo sobre os atuais métodos de agitação de soluções endodônticas disponíveis no mercado, seu mecanismo de atuação e sua forma de utilização. Metodologia: Foi realizado um levantamento bibliográfico com seleção de artigos nos seguintes periódicos acadêmicos: Google acadêmico, Scielo e Pubmed. Foi observado também que não há diferenças significativas entre os sistemas EndoVac, SAF, EndoActivator e PUI, no desempenho da agitação da solução. Também concluímos que o Easy Clean promoveu uma maior limpeza do terço apical superior quando comparado ao PUI, sendo uma excelente indicação por ser de fácil utilização, bom custo-benefício e praticidade de uso.
Aplicación teórica del método Holt-Winters al problema de Credit Scoring
Authors: Banda Ortiz Humberto , Garza Morales Rodolfo
Published: April 2022

El incremento de las instituciones de microfinanzas (imf) en México ha agudizado la competencia entre estas instituciones para aumentar su participación de mercado. No obstante las imf deben de valorar de manera adecuada el otorgamiento de créditos a sus clientes potenciales. Que los posibles clientes puedan pagar o no sus créditos depende directamente de los flujos de efectivo que generen por sus operaciones. En este trabajo se hace una revisión de la literatura de los trabajos más relevantes sobre los diferentes modelos de credit scoring y se propone una metodología teórica para analizar el riesgo de crédito en la concesión de microcréditos a partir de los flujos de efectivo esperados haciendo énfasis en la estacionalidad que dichos flujos presentan. Para ello se emplea el método Holt-Winters de pronóstico no lineal, con el fin de predecir el riesgo de que un cliente pague un préstamo (credit scoring).
Innovación y ocupaciones creativas. El caso de los diseñadores gráficos
Authors: Brunet Icart Ignasi , Santamaria Velasco Carlos Alberto , Pac Salas David
Published: April 2022

En este artículo presentamos una investigación exploratoria sobre el impacto que tiene la innovación en las ocupaciones más estratégicas, y se presenta y se discute la teoría sobre la clase creativa de Florida (2002) en el marco del denominado declive de las clases medias. En términos académicos plantea un estudio de la correlación entre clases creativas y ciudades creativas, y la relación entre ambos aspectos es inédita en España. Por otra parte, se toma en serio el carácter social de la innovación y de la creatividad, lo que diferencia esta investigación de lo que se realiza en otros ámbitos de conocimiento. A nivel de resultados se observa que los diseñadores gráficos analizados combinan un particular estilo de vida que activa la creatividad e innovación. Para varios de los diseñadores gráficos entrevistados resulta crucial la conexión entre trabajo y ocio. Por tanto, la oferta de ocio del lugar donde viven es muy importante para estas ocupaciones creativas (Florida, 2002). Por otro lado, en la actualidad, se muestra con nitidez el declive de la clase media en estos profesionales.
La responsabilidad social y los impactos que influyen en la competitividad de las pymes manufactureras de Guadalajara
Authors: Mayorga Salamanca Paola I. , Sánchez Gutiérrez José , González Uribe Elsa Georgina
Published: April 2022

La responsabilidad social corporativa (Rsc) es el rol que le toca desempeñar a las empresas a favor del desarrollo sostenible, es decir, a favor del equilibrio entre el crecimiento económico, el bienestar social y el aprovechamiento de los recursos naturales y el medio ambiente. Este equilibrio es vital para la operación de los negocios. Las empresas deben pasar a formar parte activa de los retos que tienen como parte de la sociedad, por su propio interés de tener un entorno más estable y próspero. Por lo tanto, el enfoque que se pretende en el siguiente trabajo es la Rsc dentro de las pymes manufactureras de la zona metropolitana de Guadalajara y los efectos que produce en la competitividad, para obtener empresas más productivas, competitivas y con mejor posicionamiento internacional. Lo anterior se comprobó mediante el uso de un instrumento de medición (escala de Likert) cuyos resultados fueron analizados mediante los softwares spss y eqs.
Comportamiento y bienestar financiero como factores competitivos en el personal académico de una institución de Educación Superior
Authors: Duarte Cáceres Laura Guillermina , Rosado Muñoz Yolanda Leonor , Basulto Triay Jorge Humberto
Published: April 2022

Los problemas de salud y de finanzas personales afectan a gran diversidad de hogares. La falta de un comportamiento adecuado en la administración de las finanzas produce, entre otras consecuencias, una gran ansiedad o estrés. El aumento de estrés y la ansiedad van de la mano cuando no se tiene control del dinero, haciendo de esta forma que no se alcance el bienestar financiero (Tyson, 2006). Este trabajo, a través de un estudio cuantitativo, tiene como objetivo establecer la relación entre el comportamiento financiero y el bienestar financiero. Los resultados se obtuvieron a través de una encuesta aplicada en el mes de agosto y septiembre de 2012. El análisis de la información determina que el modelo de regresión lineal explica de manera razonable la relación entre las variables comportamiento financiero y bienestar financiero
Historisches Lernen und Politische Bildung mit dem neuen Lehrplan 21 auf des Sekundarstufe l
Authors: Gautschi Peter
Published: April 2022

Since 31 October 2015, the 21 German-speaking cantons have at their disposal the new and shared curriculum ‘Lehrplan 21’ (abbrev. LP21) for the compulsory nine years of school – at least on paper and online. Anyhow, each canton decides itself, following its own rules and laws, whether it will introduce this curriculum as it is, with alterations, or adapted to special cantonal needs. Gaining a simple overview over the curriculum situation in the German-speaking part of Switzerland is still a complicated task. This text gives a presentation of the LP21’s propositions concerning civic and historical learning on the secondary I level.
Quand la politique s'affiche
Authors: Lehmann Prisca , Wicki Julien
Published: April 2022

L’article présente une séquence d’enseignement proposée aux élèves du Gymnase d’Yverdon dans le cadre des élections fédérales de 2015. Le but étant de les amener à comprendre le fonctionnement de l’État fédéral suisse, présenter l’idéologie des différents partis politiques et réfléchir aux codes de la communication politique en réalisant des affiches électorales pour des partis fictifs.
Global une intersectional. Prolegomena zu einer noch neueren Geschichte der Schweiz
Authors: Schär Bernhard C.
Published: April 2022

This article critically examines some of the recent works in Swiss national history. It argues that many of these works suffer, albeit in different ways, from a too narrowly construed, Eurocentric perspective. Consequently, they fail to offer an understandinf of how Switzerland both shaped and was shaped by processes of imperial globalisation since the 1500s. The article goes on to argue for a `post-patriotic` conception of Swiss national history that seeks to uncover how Swiss global entanglements fed into various hierarchies between gender groups, social classes, races and religious communities. The article ends with a historical example from 16th century Basel and Geneva, where book printers published books on the Spanish conquests of the Americas. The example illustrates how the historical beginnings of a Swiss nation and the beginnings of imperial globalisation in the 1500s were closely intertwined processes – and how the trajectories of Swiss history and the history of the world have remained intertwined ever since.
Les représentations sociales des élèves de cycle 3 sur les objets des hommes et des femmes de Cro-Magnon
Authors: De Carlos Philippe
Published: April 2022

This interdisciplinary work sets out the theory of didactic transposition and the intermediate model of the appropriation of history. The analysis concerns an analysis of elementary school students’ representations of the objects of Cro-Magnon men and women with regard to the historical social knowledge and the knowledge to be taught. We observe that the pupils’ knowledge of common sense is more socially represented than socially built. The distance between the scientific knowledge and the knowledge to be taught is such that it is possible to speak about an epistemological breakthrough.
Antibiogram of E. coli and Salmonella spp. isolated from chicken meat and frozen milk in Barishal city, Bangladesh
Authors: Rahman M. A. , Ahmed M. S.
Published: April 2022

Background: Food safety is now a global issue especially in developing countries like Bangladesh. Foodborne diseases are leading causes of illness and death in man, animals and birds in the world. Antibiotic resistant Salmonella and E. coli may transfer these resistances to humans through consuming chicken meat and frozen milk available in the market. There is no study on the microbiological load in chicken meat and frozen milk marketed in Barishal city. Therefore, the present study was designed to assess the contamination of E. coli and Salmonella spp. in chicken meat and frozen milk along with their antimicrobial resistance pattern in Barishal city.
Methods: A total of 40 samples including frozen milk (n=20) and chicken meat (n=20) were aseptically collected between July 2020 and June 2021 from a renowned shop and open retail market of the municipal area in Barishal city. The isolation and identification of E. coli and Salmonella spp. were done by conventional techniques. The antimicrobial profile was evaluated through a disk diffusion method.
Results: The overall detection of E. coli and Salmonella spp. were 62.5% and 32.5% in milk and chicken meat specimens. No salmonella was detected in milk samples whereas Salmonella spp. was detected only in 65% of chicken meat samples. An overall 100% of the isolates were multi-drug resistant (MDR). Both E. coli and Salmonella spp. isolated from chicken meat and milk were highly sensitive to amikacin (71%-100%) followed by gentamicin (64%-87%), sulpha-trimethoprim (13%-67%); and highly resistant (100%) to oxytetracycline, amoxicillin, and ciprofloxacin.
Conclusions: Chicken meat and milk should be cooked or heated thoroughly before consumption. Amikacin, gentamicin, and sulfa-trimethoprim should be the drugs of choice for the treatment of salmonellosis and colibacillosis in dairy and poultry in the study area. Hygienic and sanitary measures should be taken in all aspects from the farm to fork.
Science, Pseudo-science, False, and Fake “science”. Why is this happening, and what can you do?
Authors: Balogh Lajos P
Published: April 2022

<img src=”

https://s3.amazonaws.com/production.scholastica/article/34241/large/res_articles.jpeg?1649278121”>

Science publishing has many problems today. Some of them are caused by external factors, such as the computer and internet revolution. Others are because of the publication explosion and the resulting imbalance between the interests of science, authors, institutions, and the publishing business. However, these pains are part of the overall growth, nothing more. Society needs science more than ever, but progress cannot be made without reliable communication in publications. Publications are not science; they are yesterday’s information and knowledge, which are organized, stored, and shared on various media. It is important to understand actual problems with publications and consider what you can do.
Primary Percutaneous Coronary Intervention of ST-segment Elevated Myocardial Infarction- Experiences in a Tertiary Care Hospital
Authors: Islam AHM Waliul , Munwar Shams , Reza AQM , Bhuiyan Azfar H , Ahmed Tamzeed , Rahman Kazi Atiqur , Ali M Atahar , Alam Shamsul , Rahman Zia Ur , Yusuf Intekhab , Islam Nighat , Hasan Mahmud , Siddique Atique bin , Bala Poppy , Haque Md Zahidul , Alam Md Asiful , Tanvir Hossain A
Published: April 2022

Background: Primary percutaneous coronary intervention (pPCI) is the preferred and established mode of treatment in ST elevated myocardial infarction (STEMI). Exact data on procedural outcome in patient undergoing primary PCI in our population is not well documented. We have carried out this study to see the prognosis, in-hospital, and 12-month survival outcome of our patients.
Methods: Patients were enrolled in the observational non-randomized prospective cohort between November 2017-Mar 2020, who were presented into our emergency department with acute onset of severe chest pain or angina with ECG evidenced acute ST elevated myocardial infarction. Total 182 patient (Female 14; Male 168) were enrolled in this study.
Results: Out of 182 patients, anterior MI were 47.8% (n=87) and inferior MI 50.5% (n=92) and lateral MI 1.6% (n=3). Presentation to ER from the onset of chest pain for female :123 min vs. male: 112 min and average door-to-balloon time were for female: 53 min vs. male: 50 min. Hospital admission of STEMI were more after 5 pm to next morning 9 am. Death were more in anterior STEMI than inferior STEMI. At presentation 10.4% (n=19) patents were in cardiogenic shock with STEMI, 42.1%(n=8) patients with anterior MI, 57.9% (n=11) in inferior MI group. Total, 15 (8.2%) patients died; 93.3% (n=14) within one week of primary PCI due to shock and poor LV function and subsequent development of LVF with arrhythmia and 6.7% (n=1) patient died 6 months after pPCI due to other cause.
Conclusion: In this prospective observational cohort study, we found that PCI is a good and effective treatment modality in treating STEMI patient with better myocardial salvage and avoidance of life-threatening complications. Our procedural success rate is 91.8% and patients are doing well with regular follow up at our OPD 12-months after primary PCI.
Cardiovasc j 2022; 14(2): 111-120
In-hospital Outcome of Acute Anterior Myocardial Infarction with Right Ventricular Dysfunction
Authors: Hossain Md Iqbal , Ullah Mohammad , Rahman Md Ataur , Ali Md Bonday , Akanda Md Abdul Kader
Published: April 2022

Background: In anterior ST-segment elevation myocardial infarction (STEMI), attention paid mainly to the left ventricle. The predictive significance of right ventricular (RV) dysfunction in patients with anterior STEMI has been frequently neglected. In this study, we evaluated the prognostic effect of RV dysfunction on in-hospital outcomes in patients with first anterior STEMI.
Methods: Present study is based on the analysis of 77 patients admitted to Coronary care unit of the Sir Salimullah Medical College & Mitford Hospital, Dhaka during April, 2019 to March, 2020, with acute anterior wall myocardial infarction. 12 lead ECG with thorough physical examination was done along with echocardiographic assessment of RV and LV function within index hospitalization, preferably within 24 hours of admission. Patients were divided into two groups depending on right ventricular function assessment. Group I included anterior MI with right ventricular dysfunction and group II included anterior MI without right ventricular dysfunction. In hospital outcomes were observed and compared between two groups.
Results: Patients with RV dysfunction had statistically significant higher incidence of cardiogenic shock (22.2 % vs. 2.4%, p < 0.05), acute heart failure (69.4% vs. 24.4%, p < 0.05), arrhythmia (11.1% vs. 0.0%, p < 0.05), increase length of hospital stay in patients of RV dysfunction group. In-hospital mortality was non significantly higher in RV dysfunction group (8.3% vs. 2.4%, p > 0.305).
Conclusion: In this study, we observed that in-hospital outcomes were worse in patients with anterior STEMI with RV dysfunction and demands more intense invasive management. Thus, special care should be given for the assessment function of right ventricle in anterior STEMI.
Cardiovasc j 2022; 14(2): 128-134
Bicentenario del Perú: problema y posibilidad
Authors: Editor
Published: April 2022

El año 2021 conmemoramos 200 años de la proclamación de la Independencia del Perú y lo hacemos en un contexto impensable hasta no hace mucho: en medio de una fuerte crisis sanitaria y política.La primera respondió a la pandemia de coronavirus, que en el país ha dejado más de 200 mil fallecidos; lo cual, contra todo pronóstico, supuso el suceso más mortífero de nuestra historia republicana y nos llevó a encabezar la lista de los países con peor gestión frente a la emergencia sanitaria. En ese contexto, la crisis política que veníamos afrontando desde años antes de la pandemia se ahondó y, por consiguiente, llegamos a tener cuatro presidentes en menos de un año: suceso inédito para los cánones de nuestra época. A la crisis política y de salud le acompañó la consecuente crisis económica, que nos llevó a tener un retroceso del PBI solo equiparable a los tiempos de la guerra del Pacífico, aunque, merece decirse, las institucionesespecializadas en materia de economía han sostenido que el Perú tendrá un crecimiento importante en los próximos dos años.
El indígena y su proceso independentista: Huarochirí desde finales de 1820 hasta mayo de 1821
Authors: Asencio Erik Felix
Published: April 2022

La nueva documentación sobre la Independencia del Perú, en conjunto con las memorias de los propio participantes de este acontecimiento histórico, han permitido que se pueda construir y describir en la presente investigación la valerosa participación del indígena huarochirano por la emancipación, desde finales de 1820, con la formación de la primera partida guerrillera al mando de Quispe Ninavilca y José Manrique, hasta mayo de 1821, esto es, poco antes del inicio de la segunda campaña a la sierra de Arenales. Se describe el inicio de la formación de las partidas huarochiranas, así como sus primeros enfrentamientos con las fuerzas realistas, principalmente con las comandadas por Monet y Valdez en puntos estratégicos de la zona como San Mateo y Carampoma.
Érfali rugalmatlanság, az artériás stiffness klinikai jelentősége időskorban
Authors: Benczúr Béla
Published: April 2022

A magasvérnyomás-betegség és a cardiovascularis kockázat az életkor előrehaladtával egyre gyakoribbá válik. Ugyanakkor az öregedés folyamata bizonyos egyénekben sokkal gyorsabbnak tűnik, ami tükröződik a korai vascularis öregedés (early vascular aging, EVA) tünetegyüttesében. Az ütőerek falának rugalmatlanná válásában, az artériás stiffness kialakításában a hypertonia és az öregedés játssza a legfőbb szerepet, amely lényege az EVA-nak: a nagy elasztikus arté­riák (főleg az aorta) falának középső rétege veszít a rugalmasságából. Ez a folyamat jól mérhető a pulzushullám terjedési sebességével. Az idős hypertoniás egyénekben a nagy artériák rugalmatlansága, a szisztolés és diasztolés vérnyomás különbsége fokozódik, a pulzusnyomás megnő, köszönhetően a hullám-visszaverődésnek. Az érfali rugalmatlanságnak prediktív szerepe van a ké­sőbbi szív-ér rendszeri események (koszorúér-betegség, stroke, vascularis dementia), de még az összmortalitás szempontjából is. A korai vascularis öregedés és a szupernormális vascularis öregedés (supernormal vascular aging, SUPERNOVA) koncepciója segít ér­telmezni, miért alakulnak ki egyesekben korai célszervkárosodások és érrendszeri szövődmények, mások miért maradnak jó­val „fiatalabbak” kronológiai életkoruknál. Új gyógyszereket fejlesztettek az EVA kezelésére, melyeknek akkor lehet szerepük, ha az életmódkezelés és a hagyományos, ri­zi­kó­faktorokat csökkentő gyógyszerek hatása már nem elegendő.
O DELIVERY COMO FENÔMENO CONTEMPORÂNEO E OS IMPACTOS SOCIAIS
Authors:   UEMG - Universidade do Estado de Minas Gerais - Unidade Frutal, NAIRA Elida , GARCIA Geovana ,   Universidade do Estado de Minas Gerais - Unidade Frutal, ASSUNÇÃO Jessica ,   Universidade do Estado de Minas Gerais - Unidade Frutal, LEONEL Maria Clara ,   Universidade do Estado de Minas Gerais - Unidade Frutal, FERNANDES Matheus ,   Universidade do Estado de Minas Gerais - Unidade Frutal, PESSOA Marcelo ,   Universidade do Estado de Minas Gerais - Unidade Frutal
Published: April 2022

This study focuses on analyzing the impacts generated by the home delivery service for society, especially during the COVID-19 pandemic. Methodologically, we will review the literature on physical and digital collections. This project aims to identify the importance of this new profession, as well as the changes brought to society since its emergence. Justifies the accomplishment of this research, the importance of bringing to society important aspects of this new work format and its positive and negative points in the current labor scenario. The first results point to a reality of ease and convenience for the consumer, which contributes to slowly moving the consumer and the worker away from living in society, giving rise to labor problems, such as the increase in informal work and emotional issues, given the absence of social conviviality. The corpus of analysis will be taken from documents, electronic addresses and published articles about the advancement of this informal work environment after the emergence of COVID-19.
International Journal of Multidisciplinary Research and Studies
Authors:   Departamento de Geometría y Topología. Facultad de Matemáticas. Universidad de Sevilla (Spain), Valdés Juan Núñez Valdés
Published: April 2022

This paper deals with the beginnings and historical evolution of Pharmacy studies in Great Britain and on the role played by the first women who practiced the profession there, The circumstances of that time, which made it very difficult for a woman to work in that area, the biography of the first English woman licensed in Pharmacy, Fanny Deacon, and the biographies of the women who followed her as graduates in Pharmacy in Great Britain are commented, detailing not only their personal data but also the impact they had on the evolution and development of Pharmacy studies in their country. These women were Alice Vickery, Isabella Skinner Clarke, Margaret Elizabeth Buchanan, Rose Coombes Minshull, and Agnes Thompson Borrowman. The main objective of the paper is to reveal the figures of these first women in Pharmacy in Great Britain to society, To do this, the methodology used has been usual in researches of this type: search of data on these women in bibliographical and computer sources, as well as in historic archives. As the main results, the biographies of these pioneers pharmacist women mentioned above have been elaborated.
Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs
Authors: Zhou Man , Wen Lijuan , Wang Cui , Lei Qiao , Li Yongxiu , Yi Xiaoqing
Published: April 2022

Paclitaxel (PTX) is a broad-spectrum chemotherapy drug employed in the treatment of a variety of tumors. However, the clinical applications of PTX are limited by its poor water solubility. Adjuvants are widely used to overcome this issue. However, these adjuvants often have side effects and poor biodistribution. The smart drug delivery system is a promising strategy for the improvement of solubility, permeability, and stability of drugs, and can promote sustained controlled release, increasing therapeutic efficacy and reducing side effects. Polymeric prodrugs show great advantages for drug delivery due to their high drug loading and stability. There has been some groundbreaking work in the development of PTX-based stimulus-sensitive polymeric prodrug micelles, which is summarized in this study. We consider these in terms of the four main types of stimulus (pH, reduction, enzyme, and reactive oxygen species (ROS)). The design, synthesis, and biomedical applications of stimulus-responsive polymeric prodrugs of PTX are reviewed, and the current research results and future directions of the field are summarized.
Role of the Mosaic Cisternal Maturation Machinery in Glycan Synthesis and Oncogenesis
Authors: Sahu P. , Balakrishnan A. , Di Martino R. , Luini A. , Russo D.
Published: April 2022

Tumorigenesis is associated with the deregulation of multiple processes, among which the glycosylation of lipids and proteins is one of the most extensively affected. However, in most cases, it remains unclear whether aberrant glycosylation is a cause, a link in the pathogenetic chain, or a mere consequence of tumorigenesis. In other cases, instead, studies have shown that aberrant glycans can promote oncogenesis. To comprehend how aberrant glycans are generated it is necessary to clarify the underlying mechanisms of glycan synthesis at the Golgi apparatus, which are still poorly understood. Important factors that determine the glycosylation potential of the Golgi apparatus are the levels and intra-Golgi localization of the glycosylation enzymes. These factors are regulated by the process of cisternal maturation which transports the cargoes through the Golgi apparatus while retaining the glycosylation enzymes in the organelle. This mechanism has till now been considered a single, house-keeping and constitutive function. Instead, we here propose that it is a mosaic of pathways, each controlling specific set of functionally related glycosylation enzymes. This changes the conception of cisternal maturation from a constitutive to a highly regulated function. In this new light, we discuss potential new groups oncogenes among the cisternal maturation machinery that can contribute to aberrant glycosylation observed in cancer cells. Further, we also discuss the prospects of novel anticancer treatments targeting the intra-Golgi trafficking process, particularly the cisternal maturation mechanism, to control/inhibit the production of pro-tumorigenic glycans.
Role of Interfacial Bonding in Tribochemical Wear
Authors: Luo Chunsheng , Jiang Yilong , Liu Yangqin , Wang Yang , Sun Junhui , Qian Linmao , Chen Lei
Published: April 2022

Tribochemical wear of contact materials is an important issue in science and engineering. Understanding the mechanisms of tribochemical wear at an atomic scale is favorable to avoid device failure, improve the durability of materials, and even achieve ultra-precision manufacturing. Hence, this article reviews some of the latest developments of tribochemical wear of typical materials at micro/nano-scale that are commonly used as solid lubricants, tribo-elements, or structural materials of the micro-electromechanical devices, focusing on their universal mechanisms based on the studies from experiments and numerical simulations. Particular focus is given to the fact that the friction-induced formation of interfacial bonding plays a critical role in the wear of frictional systems at the atomic scale.
Antimicrobial Effects and Active Compounds of the Root of Aucklandia Lappa Decne (Radix Aucklandiae)
Authors: Cai Xuewei , Yang Chunping , Qin Guangwei , Zhang Min , Bi Yan , Qiu Xiaoyan , Lu Liya , Chen Huabao
Published: April 2022

The development of new biological fungicides using plant metabolites has become an important direction for pesticide development, and previous studies found that Radix Aucklandiae had a certain inhibitory effect on plant pathogens. In this study, we systematically studied the antimicrobial activity of extracts of Radix Aucklandiae, and the active compounds were isolated, purified and structurally identified. Ethanol extracts of Radix Aucklandiae had different inhibitory effects on seven common plant-pathogenic fungi, with EC50 (concentration for 50% of maximal effect) values ranging from 114.18 mg/L to 414.08 mg/L. The extract at concentration of 1,000 mg/L had a significant control effect on strawberry grey mould and wheat powdery mildew of more than 90%. Three active compounds were isolated and purified from the extract, which were identified as alantolactone, dehydrocostus lactone and costunolide. All three compounds showed significant inhibitory effects on Botrytis cinerea, and the MIC (minimal inhibitory concentration) values were 15.63 mg/L, 3.91 mg/L and 15.63 mg/L. Dehydrocostus lactone also showed obvious inhibitory effect on Fusarium graminearum with an MIC value of 62.25 mg/L. The extract of Radix Aucklandiae has high antimicrobial activity against some common plant-pathogenic fungi, and the work lays a foundation for the development of extracts of Radix Aucklandiae as botanical fungicides.
A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin
Authors: Wei Xinjie , Luo Xuan , Xu Shuai , Xi Fengna , Zhao Tingting
Published: April 2022

Fast, convenient, and highly sensitive detection of antibiotic is essential to avoid its overuse and the possible harm. Owing to enrichment effect and antifouling ability of ultrasmall nanochannels, the vertically ordered mesoporous silica nanochannel film (VMSF) has great potential in the development of the facile electrochemiluminescence (ECL) sensor for direct and sensitive analysis of antibiotics in complex samples. In this study, we demonstrated a flexible ECL sensor based on a cost-effective electrode covered with a VMSF for sensitive detection of clindamycin. Polyethylene terephthalate coated with indium tin oxide (PET-ITO) is applied as a flexible electrode to grow VMSF using the electrochemically assisted self-assembly (EASA) method. The negatively charged VMSF nanochannels exhibit significant enrichment toward the commonly used cationic ECL luminophores, tris(2,2-bipyridyl) dichlororuthenium (II) (Ru (bpy)32+). Using the enhanced ECL of Ru (bpy)32+ by clindamycin, the developed VMSF/PET-ITO sensor can sensitively detect clindamycin. The responses were linear in the concentration range of 10 nM–25 μM and in the concentration range of 25–70 μM. Owing to the nanoscale thickness of the VMSF and the high coupling stability with the electrode substrate, the developed flexible VMSF/PET-ITO sensor exhibits high signal stability during the continuous bending process. Considering high antifouling characteristic of the VMSF, direct analysis of clindamycin in a real biological sample, human serum, is realized.