bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis: Machine vs Human Translation of Educational Scientific Texts. Challenges and Solutions
Authors: Antonova N. A. , Kuzmich I. V.
Published: September 2024

Introduction. The purpose of this article is to analyze the features of identity formation and identification processes in postmodern society and in digital society. The article explores various approaches to the concept of «identity» within the framework of socio-humanitarian theories. The interrelation of real and virtual identity, the emergence of new forms and models of identity are considered. Two approaches to the analysis of identity in a digital society are analyzed and compared: digital optimism and digital pessimism.

Methodology and sources. The article uses a comparative analysis of various theoretical approaches to identity formation. An interdisciplinary approach is used to understand the features of identity in the era of digitalization. As the main sources for the study of the phenomenon of identity there were used works of classics of sociology and psychology E. Erickson, J.G. Meade, E. Durkheim, as well as studies of representatives of modern philosophical and sociological theories Z. Bauman, A. Giddens, S. Turkle, A.A. Lisenkova, T.G. Leshkevich.

Results and discussion. It is shown that in postmodern society, identity is characterized by the processes of individualization, fragmentation and the absence of a single cultural center. In a digital society, along with the processes of individualization, there are processes of standardization and unification of person. It is concluded that in a digital society, identity has positive and negative sides. On the one hand, there is a positive vector for the use of online communications, network interaction of people, which destroys spatial and temporal boundaries, as well as social barriers. On the other hand, new types of virtual identity are being formed, challenging a person's own identity.

Conclusion. It is concluded that the digital society changes human identity, identification practices and strategies. The consequence of these processes is the formation of a person fused with digital technologies, which leads to the transformation of the social order, social norms and society as a whole.
Passgenaue Arbeitgeberberatung im regionalen Kontext
Authors: Brunow Stephan
Published: September 2024

Kernbotschaften • Regionale Gegebenheiten stellen Leitplanken für den unternehmerischen Handlungsspielraum dar • Neben arbeitsmarktbezogenen Faktoren sollten auch andere Standortfaktoren in der Beratung von Unternehmen und Individuen mitgedacht werden • Die Konzentration wirtschaftlicher Aktivitäten im Raum ist ein Ergebnis aus individuellen Entscheidungen und Marktprozessen • Die Verfügbarkeit von Fachkräften mit gewissen Qualifikationen ist nicht gleichmäßig; besondere Arbeitsnachfragewünsche sind nicht immer realisierbar • Best-Practice-Beispiele sind nicht ohne weiteres auf andere Regionen übertragbar
Qualifizierungsberatung der Bundesagentur für Arbeit als Dienstleistung für Arbeitgeberkunden – Aktuelle Erkenntnisse und zukünftige Herausforderungen für die Beratungspraxis
Authors: Stanik Tim , Freiling Thomas , Moritz Ruth
Published: September 2024

Kernbotschaften • Qualifizierungsberatung (QB) ist ein organisationsbezogenes Beratungsangebot der BA für Betriebe, um diese dabei zu unterstützen, strategische Personalthemen zu bearbeiten und z. B. über die Qualifizierung von Beschäftigten den eigenen Fachkräftebedarf zu decken. • Es zeigt sich, dass gleichermaßen Betriebe mit akuten Personalbedarfen sowie Betriebe mit perspektivischen Interessen in der Personalarbeit die QB als Dienstleistung in Anspruch nehmen. Wichtige Themenfelder in den Beratungen sind insbesondere die Personalbeschaffung, die Qualifizierung von Beschäftigten und die Mitarbeitendenbindung. • Gefragt nach bedeutsamen Aspekten im Beratungskontext der QB messen die Arbeitgeberkunden und -kundinnen guten Rahmenbedingungen in Form von einer festen Ansprechperson und guter Erreichbarkeit eine besondere Bedeutung zu. • Der Nutzen einer QB ist aus Sicht von Betrieben besonders hoch, wenn diese zur Verbesserung der Mitarbeiterzufriedenheit oder der Mitarbeiterbindung beiträgt. Aber auch Aspekte der Personalgewinnung, der Produktivitätssteigerung, der Attraktivitätssteigerung und der strategischen Personalarbeit erscheinen aus betrieblicher Perspektive nutzenbringend. • Um künftig weiterhin auch bei sich regelmäßig verändernden betrieblichen Herausforderungen eine qualitativ hochwertige und inhaltlich nachgefragte Beratungsdienstleistung anbieten zu können, stellt die weitere Professionalisierung der Beraterinnen und Berater eine wichtige Voraussetzung dar.
Agile Beratungs-Ensembles und Life Designing für die Beratung in Bildung, Beruf und Beschäftigung
Authors: Mocigemba Dennis , Theuring Thomas , Mewes Daniel , Roller Claudio
Published: September 2024

Kernbotschaften • Der Beitrag entwickelt in einem Gedankenexperiment durch Anwendung zweier Metaphern die Idee agiler Beratungs-Ensembles. • Agile Beratungs-Ensembles werden als Möglichkeit präsentiert, Beratung in Bildung, Beruf und Beschäftigung (BBB) kontinuierlich zu innovieren. • Die Arbeit agiler Beratungs-Ensembles wird beispielhaft skizziert und mit dem beratungswissenschaftlichen Paradigma des Life Designing charakterisiert. • Arbeitgeberberatung wird dabei als zunehmend notwendiges, notwendiges, ergänzen-des Element Life Designing-orientierter BBB-Beratung identifiziert.
АНАЛІЗ ЕЛАСТИЧНОСТІ ПОПИТУ ТА ПРОПОЗИЦІЇ НА РИНКУ ЛОГІСТИЧНОЇ НЕРУХОМОСТІ УКРАЇНИ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Дунська Алла , Жалдак Ганна , Служава Любов
Published: September 2024

Стаття присвячена вивченню змін, що відбулися у попиті та пропозиції на ринку логістичної нерухомості України під впливом воєнних дій. Досліджено масштаб руйнацій та пошкоджень складських об’єктів. Проаналізовані зміни розміщення складів та попит на логістичну нерухомість в різних регіонах Україні в контексті військових дій, зокрема, завдяки реалокації бізнесу та організації нових логістичних центрів. Визначено, що Львівський регіон став ключовим логістичним вузлом завдяки своїй близькості до кордонів ЄС, сприятливому бізнес-середовищу та підтримці місцевої влади. Розглянуто фактори, що вплинули на динаміку змін орендних ставок та рівня вакантності логістичної нерухомості в залежності від регіону України. Окреслено перспективи розвитку сектора логістичної нерухомості, які залишаються позитивними, особливо у західних регіонах України та в Києві. На основі статистичних даних розраховано показник еластичності пропозиції на логістичні послуги, окреслено найбільш вагомі фактори впливу на еластичність.
Conocer para gestionar. Una propuesta para producir información y conocimientos sobre estudiantes, egresados y empleadores de la Universidad de Guadalajara
Authors:   Universidad de Guadalajara, Acosta Silva Adrián , Planas Coll Jordi , Enciso Ávila María Isabel , Arce Casas Pedro Octavio , Rivas Sepúlveda Edith
Published: September 2024

Propuesta para articular los diversos instrumentos, sistemas y bases de datos empleados en la UdeG en un solo sistema que reconozca los logros y fortalezas de los diversos esfuerzos institucionales: el Sistema Integrado de Información para el Seguimiento de Estudiantes, Egresados y Empleadores (SIISEEE). Así sería posible avanzar en la construcción de una plataforma institucional que facilite obtener información rutinaria y estratégica para la toma de decisiones de los programas y políticas universitarias.
Construção e caracterização de uma lista de publicações de Murray Sidman
Authors:   Pontifícia Universidade Católica de São Paulo, Azoubel Marcos Spector , Micheletto Nilza , Sales Thais Martins
Published: September 2024

A construção e a análise de listas de publicações de autores relevantes para as diferentes áreas de produção de conhecimento pode fornecer ferramentas úteis para análises historiográficas e servir como guia de referência para pesquisadores e estudantes. Para a análise do comporta-mento, Murray Sidman é um autor com relevância amplamente reconhecida. Com base nisso, o objetivo deste trabalho foi construir e caracterizar uma lista de publicações de Sidman. Para a construção da lista aqui apresentada, uma listagem produzida em 2000 foi atualizada a partir de buscas nas plataformas PsycNet, PubMed e GoogleAcadêmico. Foram identificadas 147 publicações e 36 republicações de trabalhos com autoria de Murray Sidman, disseminadas entre os anos 1952 e 2014. A sua obra mostra-se ampla e diversificada em relação ao número de publicações, aos temas abordados e aos veículos de publicação. Seus escritos estão conti-dos em 22 livros, 40 periódicos e quatro anais de congresso. Sidman publicou tanto estudos experimentais quanto ensaios, sendo estes últimos predominantes nos últimos anos. O tema mais recorrente em seus trabalhos foi controle de estímulos. O presente artigo apresenta um método que pode ser replicado para sistematizar e analisar a obra de outros autores importan-tes na análise do comportamento.
Conversas ao redor do livro: Treino parental para a leitura dialógica
Authors:   Universidade de Brasília, Faria Vanessa Aparecida Leal , Flores Eileen Pfeiffer
Published: September 2024

A leitura dialógica (LD) é uma importante atividade para o desenvolvimento de repertórios verbais. Treinos parentais de LD com vídeo modelação têm mostrado efeitos promissores, mas poucos estudos avaliaram diretamente o efeito do treino sobre o uso de estratégias de LD pelos pais, objetivo deste estudo. Pedro, Clara e Aline participaram com seus filhos de quatro fases em um delineamento de linha-de-base múltipla por participante: Linha de Base (LB), em que leram com seus filhos como de costume; Intervenção 1 - Aprendendo a fazer pergun-tas abertas; Intervenção 2 - Aprendendo a elogiar e ampliar; Intervenção 3 - Aprendendo a variar as perguntas. Cada intervenção incluía (1) feedback sobre repertórios adquiridos na fase anterior, (2) Instruções e (3) Vídeo Modelação. Houve pouca ou nenhuma interação além da leitura do livro na LB. Perguntas e elogios resultaram em diálogo ao redor do livro imediatamente após a Intervenção 1 para Pedro e Clara e após sugestões sobre escolha de obras para Aline, mantendo-se nas sessões subsequentes. Não houve resultados sistemáticos da Intervenção 2 e a Intervenção 3 afetou apenas o comportamento de Pedro. Discute-se a maior complexidade de algumas estratégias da LD e a necessidade de outras formas de treino para ensiná-las.
Pesquisas sobre subitização em bebês: O que analistas do comportamento podem ensinar e aprender?
Authors:   Universidade Federal de Roraima, Henklain Marcelo Henrique Oliveira , Carmo João dos Santos , Andrade Paulo Estêvão ,   Universidade Federal de São Carlos, dos Santos Ferreira Paulo Roberto ,   Godsmiths University of London,   Universidade Federal da Grande Dourados
Published: September 2024

Propõe-se incentivar o desenvolvimento de pesquisas analítico-comportamentais na área de cognição numérica, que envolve pesquisas sobre comportamentos pré-matemáticos (inatos) e comportamentos matemáticos, ambos com importantes implicações ao ensino de Matemá-tica. Neste trabalho a discussão restringe-se às pesquisas sobre subitização em bebês. Foi desenvolvida uma introdução a pesquisas cognitivistas sobre subitização em bebês humanos com base nos critérios de ineditismo e de filiação às duas linhas de pesquisa descritas por Cohen & Marks (2002). Em seguida, foi apresentada uma proposta preliminar de interpreta-ção comportamental de processos psicológicos subjacentes à subitização, sempre apontando possibilidades de novos estudos e discutindo os resultados das pesquisas revisadas. Sugere-se que a interpretação skinneriana do comportamento de perceber, as pesquisas sobre compor-tamento de observação e o paradigma de equivalência de estímulos podem ser empregados numa análise inicial dos dados obtidos em pesquisas sobre subitização. Futuros artigos deve-rão fomentar pesquisas empíricas sobre subitização em bebês orientadas pela Análise Expe-rimental do Comportamento.
Improved Parameter Estimation of Three-Phase Squirrel-Cage Induction Motors Using the Nelder-Mead Simplex Algorithm
Authors: T. Nguyen Son , V. Trieu Linh , M. Pham Tu , Hoang Anh
Published: September 2024

This work presents a technique for precisely determining the characteristics of a squirrel-cage three-phase induction motor using the Nelder-Mead simplex algorithm. This approach is a frequently employed numerical optimization technique for determining the minimal value of a multi-dimensional objective function. An advantageous feature of the Nelder-Mead simplex algorithm is its independence from the need to calculate partial derivatives of the objective function. Nevertheless, similar to several optimization techniques, the Nelder-Mead simplex approach can also exhibit sensitivity to the initial conditions. Thus, the initial estimation of the parameters of the approximated equivalent circuit of the induction motor was used as the starting point for the Nelder-Mead optimization approach. The experiment's results are compared to those obtained using the polynomial regression approach to demonstrate the efficacy of the proposed method.
Human Values in Buddhist Philosophy: A Review
Authors: Nasrin Shamima
Published: September 2024

The purpose of this study is to depict human values in Buddhist philosophy. This research is completed in three steps: 1. to present a brief overview on basic human values, 2. to present a brief overview on human values in Buddhist philosophy, 3. the need for human values in today’s society. Buddhist philosophy is a philosophy of human essence. This philosophy teaches people the true human values necessary to become complete human beings. That if held, human life can be shaped and inspired by true human values. And human values are the first condition for building order and just society. Human values refer to relatively stable beliefs composed of a number of attitudes. Human values are the thoughts, goals and objectives that govern and guide human behavior, practices and activities. Fairness, honesty and decency serve as the foundation of human values. Respecting elders, serving others, good manners, tolerance, fairness, honesty etc. are examples of human values. Human values accelerate the mental development of the individual. And by thus developing personality it paves the way for good governance and puts an end to social decay. A child acquires values from family, school, community, playmates, society and traditions. These rules are also the main criteria for the formation of human values. Basically the things that deserve to be human characteristics and qualities are human values. As a result of nurturing these human values, ideological, religious or sacred issues are awakened over time. Through the concept of emotional and ideological unity, human values emerge psychologically in a person, which order and improve the state, society and family. And in this world, the teaching of Buddhist philosophy has strengthened human values among mankind. Therefore, the purpose of this paper is to present basic human values and human values in Buddhist philosophy, the need for human values in today’s society as well.
Philosophy and Progress, Vol#73-74; No#1-2; Jan-Dec 2023 P 131-149
Seyyed Hossein Nasr’s Views of Modern Science: An Evaluation
Authors: Rahman Murshida
Published: September 2024

This paper focuses on Seyyed Hossein Nasr’s views of modern science. By focusing on Nasr’s opinion of modern science this paper explores how and why he rejects mechanical and positivist views of modern scholars. This research examines why he accepts the theory of creation and appreciates the spiritual and religious worldviews of science. In so doing, this article contributes to the ongoing discourse on the issue of modern science and eternal wisdom. By reviewing the relevant literary sources, some required data are collected and then used in the analysis hereafter. In this discussion Nasr talked about practicing science while keeping religious beliefs integrated. That is why, the existence of the creator of the world has been acknowledged. Whereas he excelled in the knowledge of science. As a result, the limitations of science arise in his mind. The philosophical problems he faced in his youth were not solved by modern science or western philosophy but were solved by the holy Qur’an. He accepts Tawheed or the oneness of God. Although he accepts modern science, he criticizes the resulting secularism. Nasr said that science should be practiced while maintaining religious values. His response to modern Science was to subordinate it to the systems and principles of the Islamic worldview. Moreover, to him, Modern Science was the largest framework of Knowledge (Ilm). This Modern science does not violate the core values of Islamic knowledge but inspires it with divine inspiration. In this case, the method came to be known as the Islamization of knowledge.
Philosophy and Progress, Vol#73-74; No#1-2; Jan-Dec 2023 P 215-240
Defending Indian Philosophy from the Criticisms of Stace
Authors: Bayazid G M
Published: September 2024

In his, A Critical History of Greek Philosophy, W. T. Stace denies to give Indian schools of thought a philosophical status. He gives three reasons for that—(1) Indian thoughts have practical motivation, (2) instead of rational explanation, it is content with symbolism, and (3) India lies outside the mainstream human civilization. In the defense of Indian philosophy, these three arguments have been countered in this paper from different perspectives. It has been shown that these arguments are rooted in scientism, extreme idealism, and ethnocentrism respectively. Stace has also argued that philosophy has four leading traits—(1) discussing the universe as a whole, (2) generalizing sciences, (3) idealism, and (4) non-practical motivation. For a proper defense, it has been shown that Indian systems share those traits. At the end, a conclusive remark has been given. It has been remarked that Stace’s case is an example of ethnocentric bias and racism. It has also been suggested that the interaction of the philosophies of different civilizations is necessary for the very sake of philosophy. Though this is not the first endeavor to defend Indian philosophy, the literature review (conducted by the author) suggests that Stace’s arguments haven’t been criticized separately.
Philosophy and Progress, Vol#73-74; No#1-2; Jan-Dec 2023 P 281-314
Development of Flipbook-Based E-Module Integrated with External Features to Facilitate Student Self-Learning
Authors: Yusmar Firdha , Putra Pramudya Dwi Aristya , Ahmad Nur , Astuti Sri Rejeki Dwi
Published: September 2024

This study aims to develop a flipbook-based E-Module integrated with external features to facilitate student self-learning. This research uses a Research and Development (R&D) method with an ADDIE model, which consists of five stages, i.e., analyze, design, develop, implement, and evaluate. The needs analysis of teaching material development was conducted through surveys, interviews, and observations. The validity test used a validation instrument filled out by three experts. Practicality was measured using the results of a questionnaire filled out by students as respondents. The data collected were then analyzed quantitatively. The results showed that the flipbook-based E-Module integrated with external features was categorized as very valid with a percentage of 91.09% and very practical with a score of 90.14%. Flipbook-based E-Module facilitated student self-learning in accordance with its character, namely self-instructional, self-contained, stand-alone, adaptive, and user-friendly characteristics.
ON THE TRENDS IN THE IMPLEMENTATION OF THE INSTITUTION OF PROBATION BY THE KAZAKH PROBATION SERVICE BASED ON THE ANALYSIS OF INFORMATION ON THE NUMBER AND MOVEMENT OF CONVICTS TO PUNISHMENTS NOT RELATED TO ISOLATION FROM SOCIETY
Authors: Alimpiev Aleksej
Published: September 2024

The article, based on official statistical data on the number and movement of convicts to punishments not related to isolation from society in the Republic of Kazakhstan, examines the tendency of the implementation of the institution of probation by the Kazakh probation service. As a result of the analysis, the author comes to conclusions about the discovered patterns of probation services applying probation in the territory of the Republic of Kazakhstan.
REVIEW OF THE TEXTBOOK «PENAL ENFORCEMENT LAW OF UZBEKISTAN AND RUSSIA. GENERAL AND SPECIAL PARTS» EDITED BY N. S. SALAEV, A. P. SKIBA
Authors: Sereda Irina
Published: September 2024

The review of the textbook on penal enforcement law of Uzbekistan and Russia indicates a number of positive conclusions emphasizing its relevance, theoretical and practical significance, set out by the author’s team (H. M. Abzalovoj,
T. P. Butenko, I. A. Davydovoj, I. A. Efremovoj, Ju. A. Kashuboj, I. N. Korobovoj, N. S. Maloletkinoj, N. S. Salaevym, A. N. Sirjakovym, A. P. Skiboj, P. V. Tepljashinym, etc.). A way to improve its content is highlighted by further studying the shortcomings of the penal enforcement and other legislation of Russia and Uzbekistan. The reviewer states that the textbook reveals numerous theoretical and applied issues (regarding the specifics of the use of basic means of correction of convicts, the execution of various punishments, the implementation of types of early release from serving a sentence, etc.), is an actual work intended for researchers, teachers, employees of institutions and bodies executing punishments, and other government agencies, members of the public, adjuncts, graduate students, cadets and students of educational organizations, worthy of being published.
Transformasi kebun hidroponik konvensional menjadi energy-efficient smart urban farming berbasis IoT
Authors: Sugiarto Indar , Yogatama Astri , Tyasmoro Setyono Yudo
Published: September 2024

Urban Farming adalah teknik bercocok tanam di lingkungan perkotaan dengan memanfaatkan area, seperti halaman rumah, taman, atau bahkan atap bangunan. Untuk mengoptimalkan manfaat dari urban farming, perlu tata kelola yang baik dan terkontrol mulai dari proses awal persiapan, penanaman, perawatan sampai panen dan pasca panen. Di Surabaya ditemukan urban farming berupa kebun hidroponik yang dimiliki oleh KRPL Tambakrejo Surabaya yang tidak berfungsi dengan baik. Melalui kegiatan pengabdian masyarakat dengan metode ABCD (Asset Based Community Development), dilakukan upaya pemberdayaan dan perbaikan dengan mentransformasi kebun hidroponik konvensional mereka menjadi kebun hidroponik cerdas. Metode tersebut diimplementasi mulai dari identifikasi permasalahan yang dihadapi KRPL Tambakrejo, yaitu kesulitan pasokan air bersih, serangan hama tikus, sumber listrik yang terbatas dan cara pemasaran produk yang kurang optimal. Proses transformasi dilakukan melalui revitalisasi kebun hidroponik konvensional menjadi kebun hidroponik cerdas berbasis IoT dan bertenaga surya. Dari hasil analisa setelah dilakukan transformasi tersebut, kebun hidroponik milik KRPL Tambakrejo bisa menghasilkan keuntungan minimal Rp 4.032.000 pertahun. Selain sangat hemat energi listrik dan dapat dipantau secara langsung lewat internet, kebun hidroponik tersebut saat ini juga sudah bebas dari hama tikus.
Penerapan sistem informasi kebutuhan masyarakat dan potensi desa dalam upaya menuju desa mandiri
Authors: Sutikno  , Dafid Ach. , Sumarto
Published: September 2024

Tingginya kemiskinan dan rendahnya kinerja pembangunan ekonomi di daerah pedesaan membutuhkan sentuhan sistem informasi yang bisa mengakselerasi pertumbuhan ekonomi. Pengabdian ini menawarkan Sistem Informasi Kebutuhan Masyarakat dan Potensi Desa (SIKEMASDES). Program pengabdian masyarakat di Desa Kebundadap Timur telah melaksanakan lima bentuk pemberdayaan masyarakat yaitu: (a) Input data kebutuhan per kapita masyarakat. (b) Input data potensi ekonomi rumah tangga, usaha mikro, dan BUMDES; (c) Interpretasi hasil Aplikasi SIKEMASDES; (d) pengenalan Aplikasi SIKEMASDES dan Ekonomi Digital pada masyarakat desa; (f) Focus Group Discussion dan evaluasi untuk perbaikan sistem. Dengan adanya pemberdayaan tersebut diharapkan Desa Kebundadap Timur menjadi desa “Mandiri” dan masyarakatnya menjadi lebih sejahtera melalui pemanfaatan potensi yang ada di desa.
Melioidosis in Patients with Cancer, A Cloaked Menace: A Case Series
Authors: Jayakrishnan Sreedhar , Kumar CH Sireesh , KV Gangadharan , KP Sreelesh , Chandrashekaran Arun , Vaniyath Sudeep
Published: September 2024

Melioidosis is an infection caused by the gram-negative bacteria Burkholderia pseudomallei. The infection is endemic in South Asia and Australia, and several risk factors have been described for acquiring the infection, the most prominent among them being diabetes. Active malignancy is not a recognized common predisposing condition for this infection, but there have been several case reports of patients with underlying malignancies who have been diagnosed with concomitant melioidosis. But the increasing use of corticosteroids along with chemotherapy-induced immunosuppression could be factors that could lead to a possible rise of the infection in this patient population. The recognition of the infection is challenging due to nonspecific clinical features, but arriving at the diagnosis is crucial in view of the protracted course of antibiotics needed to treat the acute infection, while also giving eradication therapy to prevent recurrences. The authors describe a series of three cases of melioidosis in patients with active malignancy, each highlighting a different aspect of treatment of the infection.
Temel Yaşam Desteği Eğitiminde Başarı; “Bireysel Eğitim mi?”, “Grup Eğitimi mi?”: Ön Test - Son Test Randomize Kontrollü Çalışma
Authors: Yeşilyurt Maide , Faydalı Saide
Published: September 2024

Amaç: Araştırmada bireysel ve grup çalışması şeklinde iki farklı teknikle hemşirelik öğrencilerine simülasyon ortamında verilen temel yaşam desteği eğitiminin beceri düzeyine etkisinin belirlenmesi amaçlandı.
Gereç ve Yöntemler: Deneysel düzende yürütülen araştırma, Simülasyon ve Modelleme Uygulama ve Araştırma Merkezi’nde ilk yardım dersini alan (n=92) III. sınıf hemşirelik lisans öğrencileri ile gerçekleştirildi. Temel yaşam desteği ile ilgili anlatım ve gösterim tekniği ile eğitim verildikten sonra tüm öğrencilere sınıf ortamında ön test gerçekleştirildi. Simülasyon uygulamasına başlamadan tabakalı randomizasyon yöntemine göre, öğrenciler akademik ortalamaları yönünden eş değer olacak şekilde kollara (46’şar kişi) atandı. Verilerin toplanmasında, araştırmacılar tarafından literatür doğrultusunda hazırlanan soru formu ve kontrol listesi kullanıldı. Simülasyon uygulamasından 30 gün sonra son test gerçekleştirildi.
Bulgular: Öğrencilerin eğitim öncesi ve sonrası temel yaşam desteği uygulama düzeyleri incelendiğinde; bireysel kolda doğru uygulama sayıları ortalama 8,97±2,46’dan 15,28±1,75’e, grup kolunda ise 8,47±2,04’den 14,04±2,74’e yükseldi. Her iki koldaki öğrencilerinde temel yaşam desteği doğru uygulama sayıları grup içinde anlamlı artış gösterirken (p
Application of polydopamine-modified triphasic PLA/PCL-PLGA/Mg(OH)2-velvet antler polypeptides scaffold loaded with fibrocartilage stem cells for the repair of osteochondral defects
Authors: Cheng Renyi , Xie Tao , Ma Wen , Deng Peishen , Liu Chaofeng , Hong Yuchen , Liu Changyu , Tian Jinjun , Xu Yanhua
Published: September 2024

Articular cartilage defects often involve damage to both the cartilage and subchondral bone, requiring a scaffold that can meet the unique needs of each tissue type and establish an effective barrier between the bone and cartilage. In this study, we used 3D printing technology to fabricate a tri-phasic scaffold composed of PLA/PCL-PLGA/Mg(OH)₂, which includes a cartilage layer, an osteochondral interface, and a bone layer. The scaffold was filled with Velvet antler polypeptides (VAP), and its characterization was assessed using compression testing, XRD, FTIR, SEM, fluorescence microscopy, and EDS. In vitro investigation demonstrated that the scaffold not only supported osteogenesis but also promoted chondrogenic differentiation of fibrocartilage stem cells (FCSCs). n vivo experiments showed that the tri-phasic PLA/PCL-PLGA/Mg(OH)2-VAP scaffold together with FCSC, when transplanted to animal models, increased the recovery of osteochondral defects. Those results demonstrate the promising future of illustrated tri-phasic PLA/PCL-PLGA/Mg(OH)2-VAP scaffold loaded with FCSCs as a new bone and cartilage tissue engineering approach for osteochondral defects treatment.
Microbial degradation of contaminants of emerging concern: metabolic, genetic and omics insights for enhanced bioremediation
Authors: Shah Bhavik A. , Malhotra Harshit , Papade Sandesh E. , Dhamale Tushar , Ingale Omkar P. , Kasarlawar Sravanti T. , Phale Prashant S.
Published: September 2024

The perpetual release of natural/synthetic pollutants into the environment poses major risks to ecological balance and human health. Amongst these, contaminants of emerging concern (CECs) are characterized by their recent introduction/detection in various niches, thereby causing significant hazards and necessitating their removal. Pharmaceuticals, plasticizers, cyanotoxins and emerging pesticides are major groups of CECs that are highly toxic and found to occur in various compartments of the biosphere. The sources of these compounds can be multipartite including industrial discharge, improper disposal, excretion of unmetabolized residues, eutrophication etc., while their fate and persistence are determined by factors such as physico-chemical properties, environmental conditions, biodegradability and hydrological factors. The resultant exposure of these compounds to microbiota has imposed a selection pressure and resulted in evolution of metabolic pathways for their biotransformation and/or utilization as sole source of carbon and energy. Such microbial degradation phenotype can be exploited to clean-up CECs from the environment, offering a cost-effective and eco-friendly alternative to abiotic methods of removal, thereby mitigating their toxicity. However, efficient bioprocess development for bioremediation strategies requires extensive understanding of individual components such as pathway gene clusters, proteins/enzymes, metabolites and associated regulatory mechanisms. “Omics” and “Meta-omics” techniques aid in providing crucial insights into the complex interactions and functions of these components as well as microbial community, enabling more effective and targeted bioremediation. Aside from natural isolates, metabolic engineering approaches employ the application of genetic engineering to enhance metabolic diversity and degradation rates. The integration of omics data will further aid in developing systemic-level bioremediation and metabolic engineering strategies, thereby optimising the clean-up process. This review describes bacterial catabolic pathways, genetics, and application of omics and metabolic engineering for bioremediation of four major groups of CECs: pharmaceuticals, plasticizers, cyanotoxins, and emerging pesticides.
The JNK signaling pathway in intervertebral disc degeneration
Authors: Liu Ganggang , Gao Lu , Wang Yuncai , Xie Xinsheng , Gao Xuejiao , Wu Xingjie
Published: September 2024

Intervertebral disc degeneration (IDD) serves as the underlying pathology for various spinal degenerative conditions and is a primary contributor to low back pain (LBP). Recent studies have revealed a strong correlation between IDD and biological processes such as Programmed Cell Death (PCD), cellular senescence, inflammation, cell proliferation, extracellular matrix (ECM) degradation, and oxidative stress (OS). Of particular interest is the emerging evidence highlighting the significant involvement of the JNK signaling pathway in these fundamental biological processes of IDD. This paper explores the potential mechanisms through the JNK signaling pathway influences IDD in diverse ways. The objective of this article is to offer a fresh perspective and methodology for in-depth investigation into the pathogenesis of IDD by thoroughly examining the interplay between the JNK signaling pathway and IDD. Moreover, this paper summarizes the drugs and natural compounds that alleviate the progression of IDD by regulating the JNK signaling pathway. This paper aims to identify potential therapeutic targets and strategies for IDD treatment, providing valuable insights for clinical application.
Deletion of Mgat2 in spermatogonia blocks spermatogenesis
Authors: Asmat Mohd Shamoon , Zheng Xiang Yu , Nauman Mohd , Zheng Deyou , Stanley Pamela
Published: September 2024

Identifying factors required for spermatogenesis is important for understanding mechanisms of male fertility. Inactivation of either the Mgat1 or Man2a2 gene leads to a block in spermatogenesis causing infertility in male mice. MGAT1 GlcNAc-transferase initiates complex N-glycan synthesis and MAN2A2 mannosidase generates the substrate for MGAT2 GlcNAc-transferase to form a biantennary complex N-glycan. In this paper, we show that conditional deletion of Mgat2 in spermatogonia via Stra8-iCre caused a novel block in spermatogenesis, largely prior to the formation of round spermatids. Mgat2[−/−] germ cells did not bind the lectins Phaseolus vulgaris leucoagglutinin (L-PHA) or Griffonia simplicifolia II (GSA-II), similar to germ cells lacking MGAT1 and complex N-glycans. However, overall spermatogenic defects were distinct in germ cells with deleted Mgat2 versus Mgat1. In addition, RNA-seq analysis at 15 days after birth revealed a unique transcriptomic landscape in Mgat2[−/−] germ cells with genes required for sperm formation and functions being most downregulated. Bioinformatic analyses using the ingenuity pathway analysis (IPA) algorithm identified ERK and AKT as central activities. Western blot analyses of 15-day germ cell lysates confirmed that both AKT and ERK1/2 signaling were increased by loss of MGAT2 in germ cells. By contrast, Mgat1[−/−] germ cells were previously shown to have reduced ERK signaling and unchanged AKT activity. Therefore, since the loss of all complex N-glycans is common to each mutant model, the different immature N-glycans that accumulate in Mgat2[−/−] versus Mgat1[−/−] germ cells are proposed to be the basis of their unique spermatogenic phenotypes.
Designing audio processing strategies to enhance cochlear implant users' music enjoyment
Authors: May Lloyd , Hodges Aaron , Park So Yeon , Kaneshiro Blair , Berger Jonathan
Published: September 2024

Cochlear implants (CIs) provide hundreds of thousands of users with increased access to sound, particularly speech, but experiences of music are more varied. Can greater engagement by CI users in the music mixing process mutually benefit them as well as audio engineers? This paper presents an exploratory mixed-methods study that leverages insights from CI users and professional audio engineers (AEs) in the investigation of techniques to enhance CI user music enjoyment and promote empathetic practices in AEs. Analysis of data collected over a multi-step process of surveys, interviews, and iterative cycles of sound mixing and feedback revealed two mixing strategies—namely essentializing and exaggeration of musical elements—common among mixes preferred by CI users. Participant responses also highlighted systemic ableism and audism in the music industry—an industry from which CI users report feeling excluded. Specifically, AEs felt inadequately trained around aural diversity considerations and experienced anxiety around their own aural diversity. In sum, this work contributes to insights into CI user music listening preferences; how AEs approach mixing for an aurally diverse audience; and discussion around the efficacy of CI simulation, user feedback, and AE peer feedback on mix enjoyment by CI users. Based on these findings, we offer several design insights that emphasize the need for customizable music listening tools centered around user agency and enjoyment.
A semi-automatic interpretation method for utilizing InSAR results to recognize active landslides considering causative factors
Authors: Liao Weiming , Liu Pengyuan , Kang Yanfei , Chen Lichuan , Liu Manqian , Liao Minyan
Published: September 2024

Synthetic Aperture Radar Interferometry (InSAR), which can map subtle ground displacement over large areas, has been widely utilized to recognize active landslides. Nevertheless, due to various origins of subtle ground displacement, their presence on slopes may not always reflect the occurrence of active landslides. Therefore, interpretation of exact landslide-correlated deformation from InSAR results can be very challenging, especially in mountainous areas, where natural phenomenon like soil creep, anthropogenic activities and erroneous deformational signals accumulated during InSAR processing can easily lead to misinterpretation. In this paper, a two-phase interpretation method applicable to regional-scale active landslide recognition utilizing InSAR results is presented. The first phase utilizes statistical threshold and clustering analysis to detect unstable regions mapped by InSAR. The second phase introduces landslide susceptibility combined with empirical rainfall threshold, which are considered as causative factors for active landslides triggered by rainfall, to screen unstable regions indicative of active landslides. A case study validated by field survey indicates that the proposed interpretation method, when compared to a baseline model reported in the literature, can achieve better interpretation accuracy and miss rate.
Lower limb maltorsion and acetabular deformity in children and adolescents with X-linked hypophosphatemia
Authors: Stauffer Alexandra , Raimann Adalbert , Penzkofer Stefan , Ganger Rudolf , Radler Christof , Mindler Gabriel T.
Published: September 2024

Background

X-linked hypophosphatemia (XLH) is a rare monogenetic skeletal disorder. Lower limb deformities contribute substantially to impaired gait quality and burden of disease in patients with XLH. Standardized data regarding onset and severity of lower limb maltorsion are unavailable. This study aimed to evaluate lower limb maltorsion using rotational magnetic resonance imaging (MRI) and computed tomography (CT).

Methods

Rotational MRI and CT of children and adolescents with verified XLH were evaluated retrospectively. Femoral and tibial torsion, acetabular anteversion, and axial acetabular coverage were measured and compared with published age-adapted radiographic, clinical measurements and MRI data, respectively.

Results

Fifteen patients (mean age, 10.7 years) were included in the study. Decreased femoral torsion was observed in 47% (14/30 femora) and femoral retrotorsion in 17% (5/30 femora). Ten of 13 hips with coxa vara deformity presented with decreased femoral antetorsion. Reduced external tibial torsion manifested in 64% (18/28 tibiae). Abnormal axial femoral head coverage was present in 67% (20/30 hips), whereas 53% (16/30 hips) showed increased acetabular anteversion.

Conclusion

Femoral and tibial torsional pathologies were found in children and adolescents with XLH. The occurrence of severe femoral retrotorsion in a 2-year-old child prior to ambulation raises questions regarding the biomechanical impact of gait on the development of torsional deformities in XLH.
Exploring the causal effects of serum lipids and lipidomes on lewy body dementia: a Mendelian randomization study
Authors: Fu Qingan , Pan Guanrui , Yu Qingyun , Liu Zhekang , Shen Tianzhou , Ma Xiaowei , Jiang Long
Published: September 2024

Background

Lewy body dementia (LBD) is a neurodegenerative disorder characterized by the accumulation of Lewy bodies, which primarily composed of misfolded alpha-synuclein (αS). The development of LBD and APOE4 subtypes is thought to be associated with disorders of lipid metabolism. In this study, we investigated the causal relationship between serum lipids, liposomes and LBD using a two-sample Mendelian randomization (TSMR) method.

Methods

A TSMR analysis of genome-wide association study (GWAS) data for 8 serum lipids, 179 lipidomes components, LBD and its subtypes was performed, using inverse variance weighted as the primary outcome. To ensure robustness, the sensitivity analyses including MR Pleiotropy RESidual Sum and Outlier, Cochran’s test, leave-one-out method and funnel plots were performed.

Results

In this study, we found that low-density lipoprotein cholesterol (LDL-C) (OR=1.45, 95% CI=1.19-1.77, P<0.001) and remnant cholesterol (RC) (OR=2.64, 95% CI=1.64-4.28, P<0.001) had significant positive causal effects on LBD, and RC also had a positive effect on LBD in carriers of the APOE4 gene. The results of lipidome analysis showed that phosphatidylcholine (PC) (O-16:0_20:4) levels (OR=0.86, 95% CI=0.75-0.98, P=0.02) and PC (O-18:1_20:4) levels (OR=0.76, 95% CI=0.65-0.89, P <0.001) had negative causal effects on LBD, whereas phosphatidylinositol (PI) (18:1_20:4) levels had a positive causal effect on LBD (OR=1.19, 95% CI=1.02-1.39, P=0.03). For LBD with APOE4 carriers, high levels of PC (16:1_18:0) and PC (O-18:2_18:1) had a significant positive effect, while high levels of PC (O-16:1_18:0), phosphatidylethanolamine (PE) (O-18:2_18:1), sphingomyelin (SM) (d38:2), and triacylglycerol (TAG) (56:5) significantly reduced the risk. No heterogeneity and horizontal pleiotropy were observed in sensitivity analysis.

Conclusion

Elevated LDL-C and RC levels are significant risk factors for LBD, with RC also impacting APOE4-carrying LBD. Glycerophospholipids play a crucial role in the pathogenesis of LBD, but the specific components that play a role differ from those with the APOE4 carries. These findings highlight the importance of lipid metabolism in LBD and APOE4 subtypes.
Development and validation of China’s Environmental Citizenship Questionnaire: evidence from junior high school students
Authors: Gao Junhong , Jiang Yong
Published: September 2024

The cultivation of environmental citizens has become an important measure to cope with the environmental crisis, and the research on the knowledge, conceptions, skills, attitudes, values, and actions of environmental citizens using the Environmental Citizenship Questionnaire (ECQ) is becoming a research focus. The research on environmental citizenship in China mainly staying at the level of theoretical research and descriptive research due to the accuracy of the ECQ. The emergence of the ECQ-China Version is helpful to promote the empirical research on environmental citizenship in China.This study verifies the effectiveness of the ECQ by removing 16 ECQ items which are not suitable for Chinese culture and evaluating environmental citizen-related knowledge among 550 Chinese junior high school students. The ECQ-China Version, consisting of 75 items, showed convincing results for all measurements: students’ past and present environmental citizenship behavior and the essential skills, values, attitudes, and competence that an environmental citizen should be equipped with had a significant impact on students’ future environmental citizenship behavior. This study suggests that: (1) Environmental citizenship education should not only focus on knowledge education, but also include skills education. (2) Environmental citizenship education should adhere to comprehensive principles, focusing on innovative practice of ideas and methods. (3) China’s environmental citizenship education should focus on the cultivation of citizens’ ability to participate, so that environmental citizenship can become the driving force for sustainable environmental development.
Numerical study for atmospheric transport of radioactive materials for hypothetical severe nuclear accident under different meteorological conditions
Authors: Ma Zhenhui , Li Zhiming , Tang Xiuhuan , Liu Longbo , Bao Lihong , Su Chunlei , Li Da , Wang Baosheng , Zhangsun Yonggang , Hu Pan , Ma Tengyue , Chen Lixin
Published: September 2024

A study for atmospheric transport is essential for the consequence assessment of severe nuclear accidents since radionuclides could be released from the nuclear facility into the atmosphere and cause radioactive pollution in the environment. Atmospheric transport behaviors are strongly related with meteorological conditions, which can obviously influence the transport and diffusion characteristics of radioactive materials in the atmosphere; thus, it is meaningful to investigate the coupling effects between meteorological processes and transport behaviors of radioactive materials. To evaluate the influence of meteorological conditions on atmospheric transport, meteorological parameters for different seasons were first acquired by the weather research forecast model. Furthermore, atmospheric transport behaviors of radioactive materials were simulated by the meso-scale numerical model under different meteorological conditions, and numerical analyses were conducted toward transport and deposition behaviors of radioactive materials. In addition, the influence of FDDA (four-dimensional data assimilation) on meteorological parameters and atmospheric transport behaviors was researched. The present study is important for strengthening consequence assessment for severe nuclear accident and made it possible to apply the data assimilation technology in further research works.
Driver gene alterations in NSCLC patients in southern China and their correlation with clinicopathologic characteristics
Authors: Deng Lingna , Li Jinbang , Qiu Zhanlong , Wang Yanfen
Published: September 2024

Introduction

In this study, we aimed to explore the relationship between clinicopathological features and driver gene changes in Chinese NSCLC patients.

Methods

Amplification refractory mutation system PCR was used to detect the aberrations of 10 driver oncogenes in 851 Chinese NSCLC patients, and their correlation with clinicopathological characteristics was also analyzed. Moreover, three models of logistic regression were used to analyze the association between histopathology and EGFR or KRAS mutations.

Results

The top two most frequently aberrant target oncogenes were EGFR (48.06%) and KRAS (9.51%). These were followed by ALK (5.41%), HER2 (2.35%), MET (2.23%), RET (2.11%), ROS1 (1.88%), BRAF (0.47%), NRAS (0.24%), and PIK3CA (0.12%). Additionally, 11 (1.29%) patients had synchronous gene alterations in two genes. The main EGFR mutations were exon 21 L858R and exon 19-Del, which accounted for 45.97% and 42.79% of all EGFR mutations, respectively. Logistic regression analysis showed that the frequency of EGFR mutations was positively correlated with women, non-smokers, lung adenocarcinoma, and invasive non-mucinous adenocarcinoma (IA), and negatively correlated with solid nodule, micro-invasive adenocarcinoma, and solid-predominant adenocarcinoma. KRAS mutations were positively associated with men and longer tumor long diameters and negatively correlated with lung adenocarcinoma (P < 0.05 for all).

Conclusion

Our findings suggest that the EGFR mutation frequency was higher in women, non-smokers, lung adenocarcinoma, and the IA subtype in lung adenocarcinoma patients, while the KRAS mutation rate was higher in men and patients with longer tumor long diameter and lower in lung adenocarcinoma patients.