bluuebunny/crossref_metadata_2025 huggingface dataset:
Pilot Study: Neurocognitive Disorders and Colonoscopy in Older Adults
Authors: Arias Franchesca , Riverso Michael , Levy Shellie-Anne , Armstrong Rebecca , Estores David S. , Tighe Patrick , Price Catherine C.
Published: May 2019

In a preoperative anesthesia setting with integrated neuropsychology for individuals >64 years of age, we completed a pilot study examining the association between neurocognitive disorders with frequency of missed colonoscopies and quality of bowel preparation (prep). Gastroenterologists completed the Boston Bowel Preparation Scale (BBPS) for each patient. Of 47 older adults seen in our service, 68% met criteria for neurocognitive disorders. All individuals failing to attend the colonoscopy procedure had met criteria for major neurocognitive disorder. Poor bowel prep was also identified in 100% of individuals with major neurocognitive disorder and 28% of individuals with mild neurocognitive disorder. Our pilot data suggest that, in high-risk individuals, the presence of neurocognitive disorders is risk factors for missed appointments and inadequate bowel prep. These pilot data provide reference statistics for future intervention protocols.
Sensitive bioluminescence imaging of fungal dissemination to the brain in mouse models of cryptococcosis
Authors: Vanherp Liesbeth , Ristani Alexandra , Poelmans Jennifer , Hillen Amy , Lagrou Katrien , Janbon Guilhem , Brock Matthias , Himmelreich Uwe , Vande Velde Greetje
Published: May 2019

Cryptococcus neoformans is a leading cause of fungal brain infection, but the mechanism of dissemination and dynamics of cerebral infection following pulmonary disease are poorly understood. To address these questions, non-invasive techniques that can study the dynamic processes of disease development and progression in living animal models or patients are required. As such, bioluminescence imaging (BLI) has emerged as a powerful tool to evaluate the spatial and temporal distribution of infection in living animals. We aimed to study the time profile of the dissemination of cryptococcosis from the lung to the brain in murine models by engineering the first bioluminescent C. neoformans KN99α strain, expressing a sequence-optimized red-shifted luciferase. The high pathogen specificity and sensitivity of BLI was complemented by the three-dimensional anatomical information from micro-computed tomography (μCT) of the lung and magnetic resonance imaging (MRI) of the brain. These non-invasive imaging techniques provided longitudinal readouts on the spatial and temporal distribution of infection following intravenous, intranasal or endotracheal routes of inoculation. Furthermore, the imaging results correlated strongly with the fungal load in the respective organs. By obtaining dynamic and quantitative information about the extent and timing of brain infections for individual animals, we found that dissemination to the brain after primary infection of the lung is likely a late-stage event with a timeframe that is variable between animals. This novel tool in Cryptococcus research can aid the identification of host and pathogen factors involved in this process, and supports development of novel preventive or therapeutic approaches.
Guest Editor's Foreword
Authors: ARNAIZ UZQUIZA VERONICA , STAVROU CHRISTOS
Published: May 2019

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Teaching Vocabulary to Deaf Students Through Enriched Subtitling: A Case Study in Qatar
Authors: HAMDY HASSAN RAGIA , NEVES JOSELIA
Published: May 2019

This interdisciplinary study examines the impact of using enriched subtitling (ES), within a total communication (TC) holistic approach to language learning, on the acquisition of vocabulary by deaf and hard of hearing (DHH) students.The performance of the students in an experimental class, using an ES-based lesson, was compared to two classes using traditional educational methods, focusing on text reading and sign language. The classes were followed by three tests, one immediately after the class, and two other delayed tests, a day and a week later. Qualitative and quantitative data was collected and triangulated through class observations, student feedback, test results, focus group discussions, and interviews. Test results showed that the experimental class achieved the best results, supporting the research hypothesis that, when integrated in carefully planned lessons, ES can be a valuable tool to enhance vocabulary acquisition by deaf students.
The Language of Interlingual Subtitles: Studying the f Word in Skins
Authors: NIKOLIC KRISTIJAN
Published: May 2019

The language of interlingual subtitles and the effect it has on viewers is a concern for viewers of subtitled audiovisual content, subtitlers, and SVOD1 services such as Netflix2, as well as other cable, national and commercial broadcasters that show subtitled content. Subtitles are a popular form of audiovisual translation and their usage is growing worldwide. Conveying conversational dialogues from one language via subtitles to another may not come without obstacles as subtitles are a reduced, written, form of text, where many features of conversational, spoken language may be lost. Skins, a British teenage series, containing fast-paced dialogues and slang, as well as an abundance of expletives, will be used as an illustration of this topic. The subtitling of only one expletive will be compared across all seven seasons of this television series, by analysing the opening episode of each season, against different circumstances in which particular seasons were subtitled. The study of the corpus of Croatian subtitles of this TV series, based on the analysis of the opening episode of each season of this TV series has been conducted. The article aims to show that the way subtitles are depends on how they were created, under what set of circumstances.
Exploring the Combination of Subtitling and Revoicing Tasks: A Proposal for Maximising Learning Opportunities in the Italian Language Classroom
Authors: BELTRAMELLO ANASTASIA
Published: May 2019

Research has proven that audiovisual translation as an instructional tool is certainly beneficial to the enhancement of language skills, mainly listening, reading and writing. The relationship between the pragmatics of audiovisual (AV) material and the way they are learned, is still a topic that requires more investigation. In this study, clips form an Italian TV series are exploited as context-rich scaffolding on which students can build up vocabulary and develop an awareness of L2 pragmatics. This article presents an innovative didactic methodology that capitalised on the linguistic richness of audiovisual texts and sees in subtitling and revoicing tasks a great didactic potential that provides students with numerous opportunities for learning vocabulary and L2 pragmatic. In the course proposed, exposure to AV input is integrated with subtitling and revoicing tasks as well as with multimodal analysis of the video clips in order to maximise learning opportunities in the FL classroom.
TFutils: Data structures for transcription factor bioinformatics
Authors: Stubbs Benjamin J. , Gopaulakrishnan Shweta , Glass Kimberly , Pochet Nathalie , Everaert Celine , Raby Benjamin , Carey Vincent
Published: May 2019

DNA transcription is intrinsically complex. Bioinformatic work with transcription factors (TFs) is complicated by a multiplicity of data resources and annotations. The Bioconductor package TFutils includes data structures and functions to enhance the precision and utility of integrative analyses that have components involving TFs. TFutils provides catalogs of human TFs from three reference sources (CISBP, HOCOMOCO, and GO), a catalog of TF targets derived from MSigDb, and multiple approaches to enumerating TF binding sites, including an interface to results of 690 ENCODE experiments. Aspects of integration of TF binding patterns and genome-wide association study results are explored in examples.
New in Deposit Insurance
Authors: Смирнов Е. , Smirnov E.
Published: May 2019

In January of this year, Federal Law No. 322-FZ of August 3, 2018, entered into force, which was initiated by the State Duma deputies, A.G. Aksakov, Yu.P. Oleynikov, M.L. Shakkum and other parliamentarians, which extended the country’s system of deposit insurance to small businesses.
Procedures for the Implementation of Tax Audit in Kazakhstan
Authors: Березюк В. , Berezyuk V. , Бек А. , Bek A.
Published: May 2019

Th e article outlines the theoretical basis for the implementation of tax audit, defi nes its goals, objectives, as well as the principles on the basis of which the verifi cation of the full compliance with the tax obligations of the organization — the taxpayer is carried out.
The Use of Data from the Internet Environment in the Audit
Authors: Егорова И. , Egorova I.
Published: May 2019

Th e article is devoted to the possibilities of using the data of the Internet environment in auditing. The features of the use of information posted in open sources on the websites of offi cial organizations in relation to the various stages of the audit: the agreement of the terms of the audit assignment, its planning, the collection of audit evidence, the assessment of the assumption of continuity of activity and the formation of an opinion in the audit report, as well as in relation to the accounting of events aft er the reporting date. Th e article analyzes the features, advantages, disadvantages and reliability of these sources.
Economic analysis
Authors: Савицкая Глафира , Savitskaya Glafira
Published: May 2019

The methods of complex in-house analysis of the results of production and financial activity of the enterprise taking into account domestic, foreign experience and own developments of the author are stated.
This publication provides a fuller analysis of methods of production costs, investment activities of the organization,financial results, efficiency and intensity of use of capital, cash flow, justification of management decisions,financial risk assessment. The methods of determining the effect of financial leverage, operating and financial cycles are revised. At the end of each Chapter are the control questions and tasks to consolidate knowledge.
For students of higher educational institutions of economic specialties.
Intelligent digital technologies for conceptual design of engineering solutions
Authors: Андрейчиков Александр , Andreychikov Aleksandr , Андрейчикова Ольга , Andreichicova Olga
Published: May 2019

The textbook deals with intelligent digital technologies of conceptual design of engineering solutions based on the systematic use of the laws of the structure and development of new technology, mathematical, heuristic and intelligent methods, databases of patented inventions.
The textbook is intended for students studying in the areas of higher education (master).
Using Optimization Techniques and Multidisciplinary Collaboration to Solve a Challenging Real-World Residency Scheduling Problem
Authors: Hong Young-Chae , Cohn Amy , Gorga Stephen , O’Brien Edmond , Pozehl William , Zank Jennifer
Published: May 2019

The authors consider the problem of assigning medical residents to shifts within a pediatric emergency department. They focus on both an integer programming formulation and an iterative, interactive approach in which they use this integer program as a tool within the broader process of schedule development.
Dynamic Interactive Visualizations: Implications of Seeing, Doing, and Playing for Quantitative Analysis Pedagogy
Authors: Kulkarni Shailesh S. , Mai Bin , Amirkiaee S. Yasaman , Tarakci Hakan
Published: May 2019

Teaching relatively complex quantitative topics in statistics, operations management, and management science to undergraduate as well as graduate students can pose numerous pedagogical challenges. However, several topics in these disciplines are amenable to exposition by means of dynamic interactive visualizations. We present a sample of such visualizations and discuss their implications for pedagogy. We also discuss how optimization modeling and a single data set can be leveraged to expose students to multiple variants of covering models and, more importantly, how visualizations can be used to quickly demonstrate the differences in these models. We present empirical evidence that by using dynamic interactive visualizations we are able to enhance the student learning experience.
Supporting children and young people living with ADHD
Authors: Thornton Stephanie
Published: May 2019

Living with ADHD can be very difficult for children and young people, as well as their families. Stephanie Thornton provides an overview of the condition and offers advice to help support them in the school environment.
On the Notion of Scalar Product for Finite-dimensional Diffeological Vector Spaces
Authors: Pervova Ekaterina
Published: May 2019

It is known that the only finite-dimensional diffeological vector space that admits a diffeologically smooth scalar product is the standard space of appropriate dimension. In this note, a way to dispense withthis issue is considered, by introducing a notion of pseudo-metric, which, said informally, is the least-degeneratesymmetric bilinear form on a given space. This notion is applied to make some observations on subspaces which split off as smooth direct summands (providing examples which illustrate that not all subspaces do), and then to show that the diffeological dual of a finite-dimensional diffeological vector space always has the standard diffeology and in particular, any pseudo-metric on the initial space induces, in theobvious way, a smooth scalar product on the dual.
Characterizing Graphs Of Maximum Principal Ratio
Authors: Tait Michael , Tobin Josh
Published: May 2019

The principal ratio of a connected graph, denoted Î³(G), is the ratio of the maximum and minimum entries of its Perron eigenvector. Cioaba and Gregory (2007) conjectured that the graph on n vertices maximizing Î³(G) is a kite graph, that is, a complete graph with a pendant path. In this paper, their conjecture is proved
Extremal octagonal chains with respect to the spectral radius
Authors: Geng Xianya , Li Shuchao , Wei Wei
Published: May 2019

Octagonal systems are tree-like graphs comprised of octagons that represent a class of polycyclic conjugated hydrocarbons. In this paper, a roll-attaching operation for the calculation of the characteristic polynomials of octagonal chain graphs is proposed. Based on these characteristic polynomials, the extremal octagonal chains with n octagons having the maximum and minimum spectral radii are identified.
Positive solutions of the system of operator equations $A_1X=C_1,XA_2=C_2, A_3XA^*_3=C_3, A_4XA^*_4=C_4$ in Hilbert $C^*$-modules
Authors: Eskandari Rasoul , Fang Xiaochun , Moslehian Mohammad Sal , Xu Qingxiang
Published: May 2019

Necessary and sufficient conditions are given for the operator system $A_1X=C_1$, $XA_2=C_2$, $A_3XA^*_3=C_3$, and $A_4XA^*_4=C_4$ to have a common positive solution, where $A_i$'s and $C_i$'s are adjointable operators on Hilbert $C^*$-modules. This corrects a published result by removing some gaps in its proof. Finally, a technical example is given to show that the proposed investigation in the setting of Hilbert $C^*$-modules is different from that of Hilbert spaces.
Extremal Copositive Matrices with Zero Supports of Cardinality n-2
Authors: Hildebrand Roland
Published: May 2019

Let $A \in {\cal C}^n$ be an exceptional extremal copositive $n \times n$ matrix with positive diagonal. A zero $u$ of $A$ is a non-zero nonnegative vector such that $u^TAu = 0$. The support of a zero $u$ is the index set of the positive elements of $u$. A zero $u$ is minimal if there is no other zero $v$ such that $\Supp v \subset \Supp u$ strictly. Let $G$ be the graph on $n$ vertices which has an edge $(i,j)$ if and only if $A$ has a zero with support $\{1,\dots,n\} \setminus \{i,j\}$. In this paper, it is shown that $G$ cannot contain a cycle of length strictly smaller than $n$. As a consequence, if all minimal zeros of $A$ have support of cardinality $n - 2$, then $G$ must be the cycle graph $C_n$.
Bounded linear operators that preserve the weak supermajorization on $\ell^1(I)^+$
Authors: Ljubenović Martin , Djordjevic Dragan
Published: May 2019

Linear preservers of weak supermajorization which is defined on positive functions contained in the discrete Lebesgue space $\ell^1(I)$ are characterized. Two different classes of operators that preserve the weak supermajorization are formed. It is shown that every linear preserver may be decomposed as sum of two operators from the above classes, and conversely, the sum of two operators which satisfy an additional condition is a linear preserver. Necessary and sufficient conditions under which a bounded linear operator is a linear preserver of the weak supermajorization are given. It is concluded that positive linear preservers of the weak supermajorization coincide with preservers of weak majorization and standard majorization on $\ell^1(I)$.
Determinants of Interval Matrices
Authors: Horáček Jaroslav , Hladík Milan , Matějka Josef
Published: May 2019

In this paper we shed more light on determinants of real interval matrices. Computing the exact bounds on a determinant of an interval matrix is an NP-hard problem. Therefore, attention is first paid to approximations. NP-hardness of both relative and absolute approximation is proved. Next, methods computing verified enclosures of interval determinants and their possible combination with preconditioning are discussed. A new method based on Cramer's rule was designed. It returns similar results to the state-of-the-art method, however, it is less consuming regarding computational time. Other methods transferable from real matrices (e.g., the Gerschgorin circles, Hadamard's inequality) are discussed. New results about classes of interval matrices with polynomially computable tasks related to determinant are proved (symmetric positive definite matrices, class of matrices with identity midpoint matrix, tridiagonal H-matrices). The mentioned methods were compared for random general and symmetric matrices.
On n/p-Asymptotic Distribution Of Vector Of Weighted Traces Of Powers Of Wishart Matrices
Authors: Pielaszkiewicz Jolanta , Von Rosen Dietrich , Singull Martin
Published: May 2019

The joint distribution of standardized traces of $\frac{1}{n}XX'$ and of $\Big(\frac{1}{n}XX'\Big)^2$, where the matrix $X:p\times n$ follows a matrix normal distribution is proved asymptotically to be multivariate normal under condition $\frac{{n}}{p}\overset{n,p\rightarrow\infty}{\rightarrow}c>0$. Proof relies on calculations of asymptotic moments and cumulants obtained using a recursive formula derived in Pielaszkiewicz et al. (2015). The covariance matrix of the underlying vector is explicitely given as a function of $n$ and $p$.
On Projection of a Positive Definite Matrix on a Cone of Nonnegative Definite Toeplitz Matrices
Authors: Filipiak Katarzyna , Markiewicz Augustyn , Mieldzioc Adam , Sawikowska Aneta
Published: May 2019

We consider approximation of a given positive definite matrix by nonnegative definite banded Toeplitz matrices. We show that the projection on linear space of Toeplitz matrices does not always preserve nonnegative definiteness. Therefore we characterize a convex cone of nonnegative definite banded Toeplitz matrices which depends on the matrix dimensions, and we show that the condition of positive definiteness given by Parter [{\em Numer. Math. 4}, 293--295, 1962] characterizes the asymptotic cone. In this paper we give methodology and numerical algorithm of the projection basing on the properties of a cone of nonnegative definite Toeplitz matrices. This problem can be applied in statistics, for example in the estimation of unknown covariance structures under the multi-level multivariate models, where positive definiteness is required. We conduct simulation studies to compare statistical properties of the estimators obtained by projection on the cone with a given matrix dimension and on the asymptotic cone.
On the Condition Number Theory of the Equality Constrained Indefinite Least Squares Problem
Authors: Wang Shaoxin , Li Hanyu , Yang Hu
Published: May 2019

In this paper, within a unified framework of the condition number theory, the explicit expression of the \emph{projected} condition number of the equality constrained indefinite least squares problem is presented. By setting specific norms and parameters, some widely used condition numbers, like the normwise, mixed and componentwise condition numbers follow as its special cases. Considering practical applications and computation, some new compact forms or upper bounds of the projected condition numbers are given to improve the computational efficiency. The new compact forms are of particular interest in calculating the exact value of the 2-norm projected condition numbers. When the equality constrained indefinite least squares problem degenerates into some specific least squares problems, our results give some new findings on the condition number theory of these specific least squares problems. Numerical experiments are given to illustrate our theoretical results.
On the Interval Generalized Coupled Matrix Equations
Authors: Dehghani-Madiseh Marzieh
Published: May 2019

In this work, the interval generalized coupled matrix equations \begin{equation*} \sum_{j=1}^{p}{{\bf{A}}_{ij}X_{j}}+\sum_{k=1}^{q}{Y_{k}{\bf{B}}_{ik}}={\bf{C}}_{i}, \qquad i=1,\ldots,p+q, \end{equation*} are studied in which ${\bf{A}}_{ij}$, ${\bf{B}}_{ik}$ and ${\bf{C}}_{i}$ are known real interval matrices, while $X_{j}$ and $Y_{k}$ are the unknown matrices for $j=1,\ldots,p$, $k=1,\ldots,q$ and $i=1,\ldots,p+q$. This paper discusses the so-called AE-solution sets for this system. In these types of solution sets, the elements of the involved interval matrices are quantified and all occurrences of the universal quantifier $\forall$ (if any) precede the occurrences of the existential quantifier $\exists$. The AE-solution sets are characterized and some sufficient conditions under which these types of solution sets are bounded are given. Also some approaches are proposed which include a numerical technique and an algebraic approach for enclosing some types of the AE-solution sets.
Vector Cross Product Differential and Difference Equations in R^3 and in R^7
Authors: Beites Patrícia , Nicolás Alejandro , Saraiva Paulo , Vitória José
Published: May 2019

Through a matrix approach of the $2$-fold vector cross product in $\mathbb{R}^3$ and in $\mathbb{R}^7$, some vector cross product differential and difference equations are studied. Either the classical theory or convenient Drazin inverses, of elements belonging to the class of index $1$ matrices, are applied.
Luaran Klinis Anak dengan Epilepsi yang Mengalami Relaps Setelah Penghentian Obat Antiepilepsi
Authors: Triono Agung , Herini Elisabeth Siti , Mangunatmadja Irawan
Published: May 2019

Latar belakang. Penghentian obat antiepilepsi (OAE) yang terburu-buru meningkatkan risiko relaps. Risiko resistensi obat pada anak dengan epilepsi yang mengalami relaps sangat tinggi. Hingga saat ini belum ada kesepakatan mengenai pengobatan kejang pasca relaps. Tujuan. Penelitian ini bertujuan untuk mengetahui insiden relaps, karakteristik, prediktor, luaran, dan perjalanan elektroensefalografi (EEG) anak dengan epilepsi setelah mengalami relaps. Metode. Penelitian dilakukan pada Juni-Desember 2016. Desain studi adalah potong lintang, multisite dari rekam medis tahun 2012-2016. Subjek adalah anak dengan epilepsi yang mengalami relaps. Hasil. Epilepsi relaps terjadi paling banyak dalam tahun pertama setelah dosis OAE diturunkan, 41,3% relaps terjadi dalam 6 bulan, dan 31,7% antara 6-12 bulan. Riwayat waktu kejang terkontrol lama (≥1 tahun) pada kejang sebelumnya merupakan faktor yang memengaruhi (RP 1,846 95% IK 1,056 – 3,228) kejang yang tidak terkontrol dalam waktu 6 bulan pasca relaps. Sementara variabel lain tidak signifikan berpengaruh terhadap terkontrolnya kejang dalam 6 bulan pasca relaps. Kesimpulan. Anak dengan epilepsi relaps yang memiliki riwayat waktu terkontrol kejang lama (≥1 tahun) akan lebih sulit mencapai remisi kedua pasca relaps.
Perundungan-siber (Cyberbullying) serta Masalah Emosi dan Perilaku pada Pelajar Usia 12-15 Tahun di Jakarta Pusat
Authors: Tjongjono Bonny , Gunardi Hartono , Pardede Sudung O. , Wiguna Tjhin
Published: May 2019

Latar belakang. Internet dan media sosial memberikan banyak kemudahan hidup, namun juga berpotensi untuk disalahgunakan, misalnya untuk perundungan-siber. Perundungan-siber memiliki efek negatif terhadap kesehatan fisik, psikologis, dan sosial pelaku maupun korbannya. Tujuan. Mengidentifikasi karakteristik perundungan-siber serta masalah emosi dan perilaku pelajar usia 12-15 tahun di Jakarta Pusat.Metode. Penelitian potong lintang dilakukan pada pelajar usia 12-15 tahun pada satu SMP di Jakarta Pusat. Perundungan-siber dinilai dengan kuesioner perundungan-siber Hinduja dan Patchin, yang telah diterjemahkan dan divalidasi dengan Cronbach’s α=0,72. Masalah emosi dan perilaku ditapis dengan menggunakan Strengths and Difficulties Questionnaire (SDQ).Hasil. Dari 274 pelajar yang berpartisipasi dalam penelitian ini, prevalens perundungan-siber adalah 48,2% (korban 11%, pelaku 14,2%, korban sekaligus pelaku 23%). Jenis perundungan-siber tersering yang dialami korban adalah tidak dihargai oleh orang lain (83,3%), disinggung-singgung oleh orang lain (80%), dan diacuhkan oleh orang lain (73,3%). Chat room di Line (60%) dan Instagram (60%), merupakan media sosial tersering yang digunakan. Teman sebaya laki-laki merupakan pelaku tersering (66,7%). Masalah hubungan dengan teman sebaya merupakan masalah emosi dan perilaku yang paling sering dialami oleh korban (10,2%), pelaku (13,5%), dan korban sekaligus pelaku (20,4%).Kesimpulan. Perundungan-siber merupakan suatu fenomena yang sering dijumpai pada pelajar usia 12-15 tahun di sebuah SMP di Jakarta Pusat. Masalah tersebut memerlukan perhatian yang lebih serius dari orangtua, guru dan tenaga kesehatan.
Kejadian Demam Neutropeni pada Leukemia Limfoblastik Akut Anak di RSUP Dr. Sardjito, Yogyakarta
Authors: Agnes Marshalla , Widjajanto Pudjo Hagung , Damayanti Wahyu
Published: May 2019

Latar belakang. Leukemia limfoblastik akut (LLA) merupakan keganasan yang sering ditemukan pada anak dan remaja. Demam neutropeni (DN) merupakan kedaruratan medik pada LLA yang sering menyebabkan kematian.Tujuan. Mengetahui angka kejadian dan kematian DN pada LLA anak selama terapi fase induksi.Metode. Penelitian deskriptif dengan disain potong lintang. Subjek adalah pasien LLA anak pada kurun Januari 2013 hingga Desember 2015, usia 1 bulan hingga 18 tahun dan tengah menjalani terapi fase induksi. Neutropeni ditegakkan dengan jumlah neutrofil absolut <1.500/mmk. Pengambilan sampel dilakukan secara consecutive sampling.Hasil. Terdapat 246 kasus LLA baru pada kurun waktu penelitian, 115 (46,7%) mengalami DN selama fase induksi. Kematian terjadi pada 15/115 (13%) kasus, 9/15 (60%) berhubungan dengan DN (sepsis, syok sepsis), sisanya karena sebab lainnya (sindrom lisis tumor, herniasi dan infiltrasi mening). Analisis pada kasus yang rekam mediknya selama fase induksi lengkap (59/115 atau 51,3%) menunjukkan 50/59 (84%) subjek mengalami satu kali kejadian DN, sisanya 9/59 (16%) mengalaminya 2-3 kali. Median terjadinya DN kali pertama setelah diagnosis adalah 8 hari (0-62 hari). Median durasi DN 7 hari (3-23).Kesimpulan. Kejadian demam neutropeni selama fase induksi masih tinggi dan merupakan penyebab kematian yang paling utama.
Política pública para a construção da escola popular: a rede pública municipal pelo direito de ensinar e de aprender
Authors: Santana Novais Gercina , Do Carmo Nunes Silma
Published: May 2019

Neste texto abordamos a experiência da construção da política educacional desenvolvida pela Secretaria Municipal de Educação de Uberlândia, Minas Gerais, tendo como fonte dados oriundos de uma pesquisa desenvolvida no período de 2014 a 2016, fundada na metodologia da pesquisa-ação. Os documentos - registros das rodas de conversa e dos mini fóruns - produzidos pela pesquisa-ação, foram disponibilizados para a realização de análise documental, com enfoque qualitativo. Foram analisados registros das Rodas de Conversa e dos Mini Fóruns realizados nas unidades escolares do ensino fundamental, comunicados, memorial, levantamento sobre a realidade da educação em Uberlândia e Lei Municipal nº 11.444/2013. Os resultados da análise evidenciaram a importância da referida lei, que fundamentou a construção da política pública municipal de educação cuja finalidade era garantir às classes populares educação pública, gratuita, popular, de qualidade referenciada socialmente. Mostraram a centralidade da gestão democrática no fomento da escola pública popular, da participação dos/as profissionais e demais interessados/as em educação pública e gratuita, nos espaços coletivos de discussão e elaboração de ações pedagógicas. E, também, das proposições sobre formação com os/as profissionais da educação como políticas públicas educacionais. Revelaram, ainda, a aproximação dos valores e das diretrizes, presentes nos documentos analisados, com as proposições do campo da educação popular.
Extensão universitária na educação de jovens e adultos no contexto prisional: uma proposta educativa dialógica
Authors: Isídio Alves Maria Lígia , Nascimento Dias Jucilene , Da Silva Severino Bezerra
Published: May 2019

O presente texto tem como objetivo apresentar algumas reflexões acerca das perspectivas metodológicas do "Projeto de Extensão Universitária Educação de Jovens e Adultos (EJA) no contexto prisionalâ€. Trata-se de um projeto vinculado Ã  Universidade Federal da Paraíba (UFPB), que abrangeu cerca de 80 (oitenta) educadores que atuam nas unidades prisionais do estado. É uma proposta educativa pautada na horizontalidade das decisões e no diálogo como princípio fundante para a organização, sistematização e (re)orientação da condução do processo de construção do conhecimento dos sujeitos envolvidos. Optou-se por problematizar e apresentar essa experiência a partir de autores que discutem educação popular (FREIRE, 1981, 1997, 2011a, 2011b), EJA em prisões (IRELAND, 2011; MAEYER, 2011; MUÃ‘OZ, 2011) e extensão universitária (FREIRE, 1983; MELO NETO, 2012). O percurso metodológico baseia-se numa abordagem qualitativa, com estudo de caso de cunho descritivo. Adotaram-se como procedimentos metodológicos a observação participante e a análise documental (relatório dos encontros), e têm-se como sujeitos da pesquisa, professores e agentes penitenciários da educação de jovens e adultos participantes do mencionado projeto, assim como os professores/pesquisadores. Nessa ação extensionista, consideraram-se os interesses, as necessidades educacionais e humanas dos atores que fazem o cotidiano na prisão.
A educação do campo e os desafios para uma educação infantil do campo: uma trajetória nas/das leis e nas/das lutas
Authors: Roniere Rebouças Tavares Thiago , De Bem Geralda Maria
Published: May 2019

Este texto tem como objetivo traçar o percurso que efetivou a proposta de uma educação infantil do campo. Desta forma, lançamos mão de apontamentos sobre marcos históricos que indicam essa trajetória, desde a ausência do processo educacional no espaço agrário, passando pela proposta de educação rural e as críticas a ela, o debate para elaboração de uma educação do campo e sua especificidade pedagógica infantil. Utilizamos como procedimento metodológico a pesquisa bibliográfica, estudando os autores: Caldart (2008, 1997), Fernandes (1999, 2006), Silva (2012), bem como as Diretrizes Operacionais para Educação Básica nas escolas do campo, dentre outros documentos e autores.
Chronotopes of Law. Jurisdiction, Scale and Governance (M. Valverde, 2015)
Authors: Struelens Olivier
Published: May 2019

Recensé : Mariana Valverde, Chronotopes of Law. Jurisdiction, Scale and Governance, London, Routledge, 2015, 224 p.
Humor in civil case mediations: A functional approach
Authors: Robert Christopher , Wall James A.
Published: May 2019

This study investigates humor by mediators and disputants in 95 civil case mediations. Consistent with the majority of the humor literature, as well as with the descriptive and prescriptive literature on mediation, we found that some humor was used by mediators and disputants in a “nice” and affiliative way, to control tension and to facilitate amicable relationships. Some of that humor also came in the form of reciprocal back-and-forth banter or in a positive and affiliative form that was unrelated to the mediation itself. However, many incidents of humor were harsh, as well as aggressive, and that humor often served specific functions within the mediation context. Mediators, and, to a lesser extent, disputants, used humor as a means of applying pressure to another party. Disputants, but seldom mediators, used humor defensively, to counter the pressure applied to them. We discuss how our results stand in contrast to the conventional wisdom about humor; we extend humor and conflict theory by integrating theory and perspectives on power; and we explain how our findings might extend to various social situations that involve power differentials between parties.
A Stochastic Model Based on Markov Chain to Support Vehicle-to-Grid (V2G) Operation in Smart Distribution Network
Authors: Hampannavar Santoshkumar , Yaragatti Udaykumar R. , Chavhan Suresh
Published: May 2019

In this paper a multiagent based communication framework for gridable electric vehicle (GEV) aggregation in power distribution network is proposed. Also, multi objective optimization is presented for the minimization of power losses and maximization of voltage. Furthermore multiagent system (MAS) based analytical model is proposed for GEV aggregation. Comprehensive case studies are conducted on IEEE 33 and 69 bus test distribution systems using MATLAB and it is observed that the timely and optimal placement of GEV aggregation in distribution network using multiagent communication (MAC) will lead to reduction in power losses and improvement in voltage profile. MATLAB and MOBILE C were used for the simulation studies and results demonstrate significant benefits of GEV aggregation in distribution network.
The Upper and Lower Approximations in Rough Subgroupoid of a Groupoid
Authors: Tasbozan H. , Icen I.
Published: May 2019

In this article, we introduce the concept of rough subgroupoid of a groupoid as a generalization of a rough subgroup and give some features about the lower and the upper approximations in a groupoid [1]. We give some of the characterization of them.
Maximized vertical photoluminescence from optical material with losses employing resonant excitation and extraction of photonic crystal modes
Authors: Fait Jan , Varga Marián , Hruška Karel , Remeš Zdeněk , Jurka Vlastimil , Kromka Alexander , Rezek Bohuslav , Ondič Lukáš
Published: May 2019

Optical losses of a host material together with the total internal reflection phenomenon can significantly reduce photoluminescence external quantum efficiency of embedded light-emitters. This is not only the case for light-emitting color centers in thin layers of nanocrystalline diamond, but also for silicon nanocrystals in silica dioxide matrices and for some types of perovskite materials. Here, we show that a significant boost (more than 100-fold enhancement) of the directional light emission efficiency from light-emitters in diamond can be achieved by using two-dimensional photonic crystal slabs (PhCs) to extract the light emission into vertical direction (resonant extraction) and at the same time to couple the excitation beam into the structure (resonant excitation). We have further shown that this so-called resonant extraction and excitation scheme provides the highest enhancement when the overlap between the electric field distribution of extraction leaky mode and the region of the excited light-emitters is maximized. This can be achieved by using the same type of the photonic mode for both extraction and excitation, and by optimizing the thickness of a diamond layer. The usage of the same type of modes appears to be more significant than tuning of the Q-factors of the excitation and extraction leaky modes individually. The results of our measurements are supported by the outputs of computer simulations. Our findings may be helpful in designing future PhCs for extraction of luminescence originating from various optoelectronic and sensor devices making use of the unique properties of the diamond. Moreover, our concept can be easily extended to other light-emitting materials with optical losses.
Crystal structure of 8-(3,4-dimethylbenzylidene)-6,10-dioxaspiro[4.5]decane-7,9-dione, C17H18O4
Authors: Wang Xia , Zeng Wu-Lan
Published: May 2019

C17H18O4, monoclinic, P21/c (no. 14), a = 8.6020(17) Å, b = 14.835(3) Å, c = 11.624(2) Å, β = 90.07(3), V = 1483.3(5) Å3, Z = 4, R
gt(F) = 0.0474, wR
ref(F
2) = 0.1439, T = 293(2) K.
Physicochemical Stability of Cefotaxime Sodium in Polypropylene Syringes at High Concentrations for Intensive Care Units
Authors: D’Huart Elise , Vigneron Jean , Blaise Franck , Charmillon Alexandre , Demoré Béatrice
Published: May 2019

Background

Cefotaxime sodium is an antibiotic used to treat severe infections such as in intensive care units (ICUs). The recommended dose of cefotaxime sodium can vary from 3 grams (g) to 24 g per day and publications have demonstrated that continuous administration of cefotaxime sodium is the preferred mode of administration. In ICUs, a minimum volume is used for patients requiring fluid restriction, leading to high concentrations of cefotaxime sodium.

The objective was to study the stability of cefotaxime sodium solutions at 83.3 mg/mL and 125 mg/mL, diluted in 0.9 % sodium chloride (0.9 % NaCl) or in 5 % glucose (G5 %), stored in polypropylene syringes, after the preparation and after a 6-hour and a 12-hour storage at 20–25 °C.

Methods

Three syringes for each condition were prepared. At each time of the analysis, three samples for each syringe were prepared and analysed by high performance liquid chromatography (HPLC) coupled to a photodiode array detector. The method was validated according to the International Conference on Harmonisation Q2(R1). Physical stability was evaluated by visual and subvisual inspection (turbidimetry by UV spectrophotometry at 350, 410 and 550 nm as recommended by the European Consensus Conference). pH and osmolality values were measured at each time of the analysis.

Results

For each solvent, cefotaxime sodium solutions at 83.3 mg/mL and 125 mg/mL retained more than 90 % of the initial concentration after 12 hours. During the stability study, pH values decreased slightly, the intensity of the yellow colour increased and values of absorbance increased progressively for each wavelength and each condition. An additional peak with a relative retention of 3.01 was also observed after the forced degradation gradually increased up to 4.01 % and 3.17 % of the total of surface area of the peaks present on the chromatogram after 12 hours in 0.9 % NaCl and in G5 % respectively.

Conclusions

In view of the results and despite the fact that solutions retained more than 90 % of the initial concentration after HPLC analysis, we propose to limit the stability of cefotaxime sodium in 0.9 % NaCl and G5 % at 83.3 and 125 mg/mL at 6 hours. These stability data of highly concentrated solutions provide an additional knowledge to assist ICUs in daily practice. This work also demonstrates that highly concentrated cefotaxime sodium solutions are physically unstable after a 6-hour storage and cannot be administered as a daily infusion.
Lignin-Based Carbon Nanomaterials—The Future Scope
Authors: Addepally Uma , Gandham Vani , Palety Kiran Kumari , Kanakaraju Yerra
Published: May 2019

Carbon, a versatile material available in nature, can assume various allotropic forms, which improves its chances of useful exploitation in various applications. The application scope increases for carbon when it is brought to nanosize structures, like fullerenes and related materials, carbon nanotubes, carbon nanofibers, graphene, and carbon nanocomposites with better mechanical, thermal, electronic, and electrical properties, coupled with chemical robustness. Various precursor materials used for carbon nanostructures include hydrocarbons, carbonaceous industrial wastes, carbon blacks, carbon nano-onions etc. The high cost of precursors in particular is caused by petro-based sources, and manufacturing costs are narrowing the applications of carbon materials in high-performance structural materials. One alternative is biobased precursor materials like lignin, a polymeric aromatic compound with various side chain substituents found in plant cell walls. Lignin consists of more than 60 % carbon on a theoretical basis and can be a green carbon source for the production of carbon-based nanomaterials. Worldwide data show that the paper and pulp industry alone produces ∼50 × 109 kg of lignin per annum. The E20 or E30 norms of biofuel blending shows that each ton of biomass produces ∼15–25 % (w/w) of lignin as a by-product. Therefore, precursor material limitation can be avoided if lignin-based sources are used for nanomaterial production. In addition to these, animal manure from herbivores can also be considered for the same beause the manure contains significant amounts of microbial, processed lignin in the rumen with decreased degree of polymerization, making it suitable to play with the structure for various applications, particularly with nanocomposites. Some of the applications based on lignin might require preliminary functionalizations to the source material. Lignin-based nanomaterials have various applications in many biocompatible-based applications, such as for cancer diagnosis, drug delivery, optical sensors, tissue engineering, energy storage devices, air filtration, oil-water separation, electronics, and catalysis, etc.
The importance of contractile reserve in predicting exercise tolerance in asymptomatic patients with severe aortic stenosis
Authors: van Zalen Jet , Badiani Sveeta , Hart Lesley M. , Marshall Andrew J. , Beale Louisa , Brickley Gary , Bhattacharyya Sanjeev , Patel Nikhil R. , Lloyd Guy W.
Published: May 2019

Background Mortality dramatically rises with the onset of symptoms in patients with severe aortic stenosis (AS). Surgery is indicated when symptoms become apparent or when there is ventricular decompensation. Cardiopulmonary exercise testing (CPET) in combination with exercise echocardiography can unmask symptoms and provides valuable information regarding contractile reserve. The aim of the present study was to determine the prevalence of reduced exercise tolerance and the parameters predicting adverse cardiovascular events.

Methods Thirty-two patients with asymptomatic severe AS were included in this study. Patients were followed up as part of an enhanced surveillance clinic.

Results Age was 69 ± 15.7 years, 75% of patients were male. Patients had a raised NT-ProBNP of 301 pg/mL. VO2peak was 19.5 ± 6.2 mL/kg/min. Forty-one percent of patients had a reduced %VO2peak and this predicted unplanned cardiac hospitalisation (P = 0.005). Exercise systolic longitudinal velocity (S′) and age were the strongest independent predictors for VO2peak (R
2 = 0.76; P < 0.0001). Exercise S′ was the strongest independent predictor for NT-ProBNP (R
2 = 0.48; P = 0.001).

Conclusion A large proportion of patients had a lower than predicted VO2peak. The major determinant of exercise and NT-ProBNP is the ability of the left ventricle (LV) to augment S′ on exercise rather than the severity of aortic valve obstruction or resting structural remodelling of the LV. Reduced exercise tolerance and more adverse remodelling, rather than valve obstruction predicted unplanned hospitalisation. This study demonstrates that for those patients, in whom a watchful waiting is an agreed strategy, a detailed assessment should be undertaken including CPET, exercise echocardiography and biomarkers to ensure those with exercise limitation and risk of decompensation are detected early and treated appropriately.
El caso CONPI y la crítica al movimiento indígena en Colombia: aportes para repensar las luchas políticas contemporáneas
Authors: Gutiérrez Lopera Esteban , Alvarado González Lizeth
Published: May 2019

This article aims to explore the dynamics that characterize the political mobilization of the ethnic sectors in Colombia, using the concept of inter-ethnicity to shape a critique of the way in which the struggles for the rights of these sectors have historically unfolded. The problem of the State will be recurrent throughout the reflection, since considerations will be made about the complex relationship that the latter, as a more or less valid figure to carry out concrete transformations, has sustained with the ethnic peoples of the country and with their demands, also discussing, in a less formal way, about the global economic scheme that disrupts this relationship. Finally, clues will be offered to rethink the conceptual frameworks that determine the ways of doing politics and to participate politically from the Colombian context.
Global Shifts in Gene Expression Profiles Accompanied with Environmental Changes in Cnidarian-Dinoflagellate Endosymbiosis
Authors: Ishii Yuu , Maruyama Shinichiro , Takahashi Hiroki , Aihara Yusuke , Yamaguchi Takeshi , Yamaguchi Katsushi , Shigenobu Shuji , Kawata Masakado , Ueno Naoto , Minagawa Jun
Published: May 2019

Stable endosymbiotic relationships between cnidarian animals and dinoflagellate algae are vital for sustaining coral reef ecosystems. Recent studies have shown that elevated seawater temperatures can cause the collapse of their endosymbiosis, known as ‘bleaching’, and result in mass mortality. However, the molecular interplay between temperature responses and symbiotic states still remains unclear. To identify candidate genes relevant to the symbiotic stability, we performed transcriptomic analyses under multiple conditions using the symbiotic and apo-symbiotic (symbiont free) Exaiptasia diaphana, an emerging model sea anemone. Gene expression patterns showed that large parts of differentially expressed genes in response to heat stress were specific to the symbiotic state, suggesting that the host sea anemone could react to environmental changes in a symbiotic state-dependent manner. Comparative analysis of expression profiles under multiple conditions highlighted candidate genes potentially important in the symbiotic state transition under heat-induced bleaching. Many of these genes were functionally associated with carbohydrate and protein metabolisms in lysosomes. Symbiont algal genes differentially expressed in hospite encode proteins related to heat shock response, calcium signaling, organellar protein transport, and sugar metabolism. Our data suggest that heat stress alters gene expression in both the hosts and symbionts. In particular, heat stress may affect the lysosome-mediated degradation and transportation of substrates such as carbohydrates through the symbiosome (phagosome-derived organelle harboring symbiont) membrane, which potentially might attenuate the stability of symbiosis and lead to bleaching-associated symbiotic state transition.