bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and feasibility of modified duct-to-mucosa pancreaticojejunostomy during pancreatoduodenectomy: A retrospective cohort study
Authors: Sun Yi , Yu Xiao-Feng , Yao Han , Xu Shi , Ma Yu-Qiao , Chai Chen
Published: September 2023

Indocyanine green (ICG) is a water-soluble fluorescent dye that is minimally toxic and widely used in gastrointestinal surgery. ICG facilitates anatomical identification of structures (e.g., ureters), assessment of lymph nodes, biliary mapping, organ perfusion and anastomosis assessment, and aids in determining the adequacy of oncological margins. In addition, ICG can be conjugated to artificially created antibodies for tumour markers, such as carcinoembryonic antigen for colorectal, breast, lung, and gastric cancer, prostate-specific antigen for prostate cancer, and cancer antigen 125 for ovarian cancer. Although ICG has shown promising results, the optimization of patient factors, dye factors, equipment, and the method of assessing fluorescence intensity could further enhance its utility. This review summarizes the clinical application of ICG in gastrointestinal surgery and discusses the emergence of novel dyes such as ZW-800 and VM678 that have demonstrated appropriate pharmacokinetic properties and improved target-to-background ratios in animal studies. With the emergence of robotic technology and the increasing reporting of ICG utility, a comprehensive review of clinical application of ICG in gastrointestinal surgery is timely and this review serves that aim.
Short- and long-term results of open vs laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments
Authors: Quan Ji-Chuan , Zhou Xin-Jun , Mei Shi-Wen , Liu Jun-Guang , Qiu Wen-Long , Zhang Jin-Zhu , Li Bo , Li Yue-Gang , Wang Xi-Shan , Chang Hu , Tang Jian-Qiang
Published: September 2023

Indocyanine green (ICG) is a water-soluble fluorescent dye that is minimally toxic and widely used in gastrointestinal surgery. ICG facilitates anatomical identification of structures (e.g., ureters), assessment of lymph nodes, biliary mapping, organ perfusion and anastomosis assessment, and aids in determining the adequacy of oncological margins. In addition, ICG can be conjugated to artificially created antibodies for tumour markers, such as carcinoembryonic antigen for colorectal, breast, lung, and gastric cancer, prostate-specific antigen for prostate cancer, and cancer antigen 125 for ovarian cancer. Although ICG has shown promising results, the optimization of patient factors, dye factors, equipment, and the method of assessing fluorescence intensity could further enhance its utility. This review summarizes the clinical application of ICG in gastrointestinal surgery and discusses the emergence of novel dyes such as ZW-800 and VM678 that have demonstrated appropriate pharmacokinetic properties and improved target-to-background ratios in animal studies. With the emergence of robotic technology and the increasing reporting of ICG utility, a comprehensive review of clinical application of ICG in gastrointestinal surgery is timely and this review serves that aim.
Effect of Torso Boundary Conditions on Spine Kinematic and Injury
Responses in Head-First Impact Assessed with a 50th Percentile Male Human Body
Model
Authors: Morgan M.I. , Corrales M. , Cripton P. , Cronin D.S.
Published: September 2023

Computational and experimental studies have been undertaken to investigate
injurious head-first impacts (HFI), which can occur during automotive rollovers.
Recent studies assume a torso surrogate mass (TSM) boundary condition, wherein
the first or first two thoracic vertebrae are potted and constrained to only
move in the vertical loading direction. The TSM boundary condition has not been
compared with a full body (FB) model computationally or experimentally for HFI.
In this study, the Global Human Body Models Consortium 50th percentile male
detailed human body model (M50-O, Version 6.0) was applied to compare the
kinematic, kinetic, and injury response of an HFI with a TSM boundary condition
(M50-TSM), and a full body boundary condition (M50-FB). Impacts (to M50-TSM and
M50-FB) were simulated between the head and a rigid plate using a commercial FE
code (LS-DYNA). The impact velocity of 3.1 m/s corresponded to the onset of
spinal injury in diving reconstructions, and the impact velocity reported in
experiments. The TSM boundary condition was simulated by applying a mass of 16
kg to the first thoracic vertebra (T1), and constraining motion to only the
vertical direction. A quantitative comparison of the head and spine impact
forces, spine kinematics, and prediction of hard tissue fracture was reported.
The M50-TSM model demonstrated a 53.4% lower (straighter) spinal curvature 10 ms
after impact, compared to the M50-FB. The lower curvature of the M50-TSM
resulted in higher neck loads during that timeframe (2.26 kN M50-TSM, 1.44 kN
M50-FB). The resulting hard tissue fracture in M50-TSM was attributed to direct
compression at an early time (<5 ms) in the impact, while M50-FB demonstrated
compression-extension fractures later (>16 ms) in the simulation. It was
concluded that kinematics, kinetics, and injury response differed for the TSM
and FB boundary conditions, and therefore these conditions are critical to
consider when investigating HFI.
Smoothed Particle Hydrodynamics to Model Spinal Canal Occlusion of a
Finite Element Functional Spinal Unit Model under Compression
Authors: Ngan S. , Rampersadh C. , Carter J. , Cronin D.S.
Published: September 2023

Compressive impacts on the cervical spine can result in bony fractures. Bone
fragments displaced into the spinal canal produce spinal canal occlusion,
increasing the potential for spinal cord injury (SCI). Human body models (HBMs)
provide an opportunity to investigate SCI but currently need to be improved in
their ability to model compression fractures and the resulting material flow.
Previous work to improve fracture prediction included the development of an
anisotropic material model for the bone (hard tissues) of the vertebrae assessed
in a functional spinal unit (FSU) model. In the FSU model, bony failure was
modeled with strain-based element erosion, with a limitation that material that
could occlude the spinal canal during compression was removed when an element
was eroded. The objective of this study was to implement a multi-physics
modeling approach, using smoothed particle hydrodynamics (SPH) with element
erosion, to simulate the movement of fractured material during central
compression of a C5-C6-C7 cervical spine segment and assess spinal canal
occlusion. The calculated maximum occlusion in the original model was 11.1%. In
contrast, the enhanced model with SPH had a maximum occlusion of 79.0%, in good
agreement with the average experimental maximum occlusion of 69.0% for
age-matched specimens. The SPH implementation to preserve fractured material
volume enabled the assessment of spinal canal occlusion.
Developing an Ovine Model of Impact Traumatic Brain
Injury
Authors: Magarey Charlie C , Quarrington Ryan D , Jones Claire F
Published: September 2023

Traumatic brain injury is a leading cause of global death and disability.
Clinically relevant large animal models are a vital tool for understanding the
biomechanics of injury, providing validation data for computation models, and
advancing clinical translation of laboratory findings. It is well-established
that large angular accelerations of the head can cause TBI, but the effect of
head impact on the extent and severity of brain pathology remains unclear.
Clinically, most TBIs occur with direct head impact, as opposed to inertial
injuries where the head is accelerated without direct impact. There are
currently no active large animal models of impact TBI. Sheep may provide a
valuable model for studying TBI biomechanics, with relatively large brains that
are similar in structure to that of humans. The aim of this project is to
develop an ovine model of impact TBI to study the relationships between impact
mechanics and brain pathology. An elastic energy impact injury device has been
developed to apply scalable head impacts to rapidly rotate the head without
causing hard tissue damage. A motion constraint device has been developed to
limit the head motion to a single plane of rotation. The apparatus has been
tested using deceased animals to assess the controllability of impact
velocities, the repeatability of head kinematics, and the dynamic response of
the head to impact. Impact velocities are effectively controlled by modulating
the elastic energy stored in the impact piston. The resulting head kinematics
are somewhat variable, and are influenced by impact location, time-dependent
postmortem tissue changes, and specimen head and neck physiology. Model
development will continue, and in vivo testing will be conducted to assess the
brain pathology following impacts of varying severity.
Restraint System Optimizations Using Diverse Human Body Models in
Frontal Crashes
Authors: Yang Zhenhao , Desai Amoghsidd , Boyle Kyle , Rupp Jonathan , Reed Matthew , Hu Jingwen
Published: September 2023

Objective: This study aimed to optimize restraint systems and
improve safety equity by using parametric human body models (HBMs) and vehicle
models accounting for variations in occupant size and shape as well as vehicle
type.

Methodology: A diverse set of finite element (FE) HBMs were
developed by morphing the GHBMC midsize male simplified model into statistically
predicted skeleton and body shape geometries with varied age, stature, and body
mass index (BMI). A parametric vehicle model was equipped with driver, front
passenger, knee, and curtain airbags along with seat belts with pretensioner(s)
and load limiter and has been validated against US-NCAP results from four
vehicles (Corolla, Accord, RAV4, F150). Ten student groups were formed for this
study, and each group picked a vehicle model, occupant side (driver vs.
passenger), and an occupant model among the 60 HBMs. About 200 frontal crash
simulations were performed with 10 combinations of vehicles (n = 4) and
occupants (m = 8). The airbag inflation, airbag vent size, seatbelt load
limiter, and steering column collapse force were varied to reach better occupant
protection. The joint injury probability (Pjoint) combining head, neck, chest,
and lower extremity injury risks was used for the design optimization. Injury
risk curves were scaled based on the skeleton size and shape of each HBM.

Results and Conclusions: We observed that tall and heavier male
occupants tend to strike through the airbag leading to higher head injury risk;
older and female occupants tend to sustain higher chest injury risk, while obese
occupants tend to have higher lower extremity injury risk. After design
optimizations, the average Pjoint was reduced from 0.576 ±
0.218 to 0.343 ± 0.044. The airbag inflation and venting were found to be highly
effective in head protection, while the belt load limit and steering column
force were sensitive to chest injury risks. Conflicting parameter effects were
found between head and chest injuries and among different occupants,
highlighting the complexity of achieving safety equity across a diverse
population. This study demonstrated the benefit of adaptive restraint systems
for a diverse population.
Summary of Poster Abstracts
Authors: Mueller Becky , Bautsch Brian , Mansfield Julie
Published: September 2023

Eighteen research posters were prepared and presented by student authors at the
18th Annual Injury Biomechanics Symposium. The posters covered a wide breadth of
works-in-progress and recently completed projects. Topics included a variety of
body regions and injury scenarios such as:

Head: Defining the mass, center of
mass, and anatomical coordinate system of the pig head and brain;
the influence of friction on oblique helmet testing; validation of
an in-ear sensor for measuring head impact exposure in American
football

Neck and spine:
Design of paramedic mannequin neck informed by adult passive neck
stiffness and range of motion data; identifying injury from
flexion-compression loading of porcine lumbar intervertebral
disc

Thorax: Tensile
material properties of costal cartilage perichondrium; finite
element models of both an ovine thorax and adipose tissue for
high-rate non-penetrating blunt
impact

Pelvis:
Injurious pelvis deformation in high-speed rear-facing frontal
impacts

Lower extremities:
Generation of 3D pediatric femur models from 2D radiographs; plantar
thickness and stiffness using ultrasound; knee injuries in skiing
and snowboarding using artificial intelligence 3D modeling; jumping
kinematics, and kinetics in athletes with secondary task of heading
a soccer ball

Full body, vehicle
occupants: Comparison of Hybrid III, THOR mid-size male,
and small female ATDs in frontal sled tests; effects of booster seat
on reclined small females during lateral oblique low-acceleration
impacts; airbag deployment for out-of-position 50th percentile male
human body model

Full body,
unique loading scenarios: Development of seat fixture and
restraints for FE human body model during vertical loading;
methodology for PMHS-occupied powered two wheeler and motor vehicle
crash scenario
Viability and adaptability of mestizo female cattle from artificial insemination compared with local
Authors: Seme Kpassi , Somenutse Koffi Ganyo , Coulibaly Fatoumata , Bonfoh Bèdibètè , Kotoe Mensah Délako , Koumessi Léopold Komi , Kossoga Kakom Assota , Pitala Wéré
Published: September 2023

The objective of this study was to determine after 48 months of age, the growth and viability of crossbreds resulting from Artificial  Insemination (AI). The methodology used was the follow-up of 39 crossbreds from IA with 40 local sisters whose births coincided. The  data collected concerned the weight of calves, mortalities and their causes. The adaptation of mestizos in the environment was  evaluated. The results showed that the weights of Mestizos calves from birth 20.65 ± 6.54 kg (Local x MO) and 23.30 ± 5.34 kg (Local x HO)  to three months of age 55.12 ± 4 .95 kg (Local x MO) and 56.65 ± 5.08 kg (Local x HO) was higher (p ≤ 0.05) than those of their local  counterparts (17.32 ± 3.74 kg and 42. 05±11.89kg). The pre-weaning mortality rate (18.19%) was higher (p ≤ 0.05) than that obtained in  the post-weaning period (11.48%) and is mainly due to calf diarrhea (37 ,30%). The Local x MO crossbreds seem better adapted than  those resulting from the Locales x HO in the climatic conditions of Togo in terms of consumption skills and sensitivity to heat. In  conclusion, the survival of crossbreeds requires permanent health monitoring and good farm management.
Dépistage biologique de la consommation récente de cannabis chez les patients schizophréniques du Centre Notre Dame de l’Espérance de Bobo-Dioulasso, Burkina Faso
Authors: Da Ollo , Zoungrana Tibaut Joseph , Tall Fatou Gueye , Thiombiano Cherileila , Meda Dimitri , Zongo Emmanuel , Dougouri Yacine Saida , Fofana Souleymane , Bamba Sanata , Siranyan Sélouké , Ouedraogo Georges Anicet
Published: September 2023

La consommation de cannabis peut entraîner la survenue de troubles psychiatriques ou aggraver des troubles psychiatriques  préexistants. L’objectif de cette étude était de dépister une consommation récente du cannabis chez les patients schizophréniques. Il  s’est agi d’une étude transversale menée du 15 mai au 15 septembre 2021. Les patients schizophréniques du Centre Notre Dame de  l’Espérance (CNDE) de BoboDioulasso ont été inclus. Le sérum obtenu à partir du sang total a été utilisé pour la détermination qualitative  in vitro des cannabinoïdes. Le principe du test reposait sur l'interaction cinétique de microparticules en solution (KIMS). Au  total, 91 patients schizophréniques ont constitué la population d’étude. Les hommes constituaient 62,63% des patients. L’âge médian des  patients était de 39 ans [minimum – maximum: 14 – 73 ans]. Le dépistage des cannabinoïdes a été positif chez 18,68% (17/91) des  patients. L’absorbance médiane des échantillons positifs était de 9 mabs avec des extrêmes de 0 mabs à 251 mabs. L’intégration d’un  dépistage biologique systématique du cannabis permettrait sans doute une meilleure prise en charge des patients atteints de troubles  mentaux.

 

English title: Biological screening of recent cannabis use among schizophrenic patients at the Centre Notre Dame de l'Espérance in Bobo-Dioulasso, Burkina Faso

Cannabis abuse may lead to the onset of psychiatric disorders or exacerbate pre-existing psychiatric disorders. The objective of this study  was to screen for recent cannabis use in patients with schizophrenia. This was a cross-sectional study performed from 15 May to 15  September 2021. Schizophrenic patients at the Centre Notre Dame de l'Espérance (CNDE) in Bobo-Dioulasso were included. Serum  obtained from whole blood was used for the in vitro qualitative determination of cannabinoids based on the kinetic interaction of  microparticles in solution (KIMS). A total of 91 schizophrenic patients were included in the study population. Men constituted 62.63% of  the patients. The Median age of the patients was 39 years [minimum – maximum: 14 – 73 years]. Cannabinoid screening was positive in  18.68% (17/91) patients. Median absorbance of positive samples was 9 mabs with extremes from 0 mabs to 251 mabs. Systematic  biological screening for canabinoid would allow a better management of patients with mental disorders.
Potentiel thérapeutique et nutritionnel de quelques échantillons de thé vert consommé dans la région de Dakar au Sénégal
Authors: Naco Mohamed El Bechir , Tirera Harouna , Tangara Benoit Yaranga , Sarr Serigne Omar , Fall Djibril , Diop Yerim Mbagnick , Ndiaye Bara , Diop Amadou
Published: September 2023

Le thé vert (Camellia sinensis) est une boisson largement consommée au Sénégal en de multiples occasions comme les rencontres  religieuses ou politiques, les cérémonies familiales (mariage, baptême, funérailles…). Ainsi l’objectif général de cette étude était de  contribuer à une meilleure connaissance de la qualité nutritionnelle et du potentiel thérapeutique du thé vert vendu dans le marché  dakarois. Les teneurs en éléments minéraux, en alcaloïdes, en composés phénoliques et en flavonoïdes de huit échantillons de thé vert  ont été déterminées par Spectrophotométrie. La méthode AOAC (Association of Official Analytical Chemists) (1990) a également été  utilisée. Par ailleurs, une évaluation du pouvoir antioxydant d’extraits d’échantillons de thé a été faite selon la méthode au DDPH. Les  résultats des analyses a montré que dans tous les échantillons le potassium était l’élément minéral majoritaire avec une teneur de  1351,34 ± 0,052 mg/100 g tandis que la plus faible valeur a été obtenue avec le cuivre (0,17 ± 0,004 mg/100 g). Les teneurs en alcaloïdes  totaux variaient entre 0,71 ± 0,0010 g et 0,32 ± 0,0020 g tandis que celles en polyphénols totaux étaient comprises entre 103,18 mg et  67,14mg. La teneur en flavonoïdes totaux la plus élevée dans le thé vert était de 49,31 mg et la plus faible était de 33,68 mg. Les extraits  de thé ont montré une activité antioxydante modérée avec une CI₅₀ minimal de 3,1 ± 0,016 mg/mL comparativement à l’acide ascorbique  (CI₅₀ = 0,09 ± 0,002 mg/mL) utilisé comme standard. Cette étude nous a permis de montrer que nos échantillons de thé vert sont riches  en éléments minéraux (potassium, sodium, calcium, magnésium, fer, zinc, et cuivre) et en composés phytochimiques (alcaloïdes,  flavonoïdes, polyphénols totaux). Ce qui pourrait expliquer leur large consommation dans la région dakaroise et forte qualité    antioxydante.
Etude ethnobotanique des plantes utilisées dans le traitement des troubles du système nerveux dans la médecine traditionnelle au Togo
Authors: Doumongue Tibanguebé , Koula Fo-doh Clefasse , Bledu Koffi Mawufemo , Gbekley Efui Holaly , Effoe Stéphane , Hoekou Yao Patrick , Donyoh Kossi , Batawila Komlan , Karou Damintoti Simplice , Tchacondo Tchadjobo
Published: September 2023

La médecine traditionnelle prend en charge diverses maladies, dont celles affectant le système nerveux, en faisant habituellement  recours aux espèces végétales. L’objectif de cette étude était de recenser les plantes utilisées en médecine traditionnelle pour le  traitement des troubles neuropsychiatriques. Une enquête ethnobotanique dans les régions Maritime et Savanes (Togo) basée sur des  entretiens semi-structurés avait enrôlée 103 professionnels des plantes. Les données de l’enquête avaient permis d’identifier 21 espèces  végétales regroupées en 17 familles. La famille des Bignoniaceae était la mieux représentée avec trois espèces. On note une forte  utilisation de Rauvolfia vomitoria (55,34%). Les racines (55%), les écorces de racines (18%) et les feuilles (17%) étaient les plus sollicitées.  La principale méthode de préparation est la décoction (48%). Les professionnels des plantes des régions maritimes et des savanes du  Togo ont des connaissances diversifiées sur la biodiversité et ses vertus thérapeutiques.

 

Englsih title: Ethnobotanical survey of plants used in the treatment of nervous system disorders in traditional medicine in Togo

Traditional medicine treats various diseases, including those affecting the nervous system, usually using plant species. The objective of  this study was to identify the plants used in traditional medicine for the treatment of neuropsychiatric disorders. An ethnobotanical  survey in the Maritime and Savanes regions (Togo) based on semi-structured interviews enrolled 103 plant professionals. The survey data  identified 21 plant species grouped into 17 families. The Bignoniaceae family was the best represented with three species. There  was a strong use of Rauvolfia vomitoria (55.34%). Roots (55%), root bark (18%) and leaves (17%) were the most stressed. The main method of preparation was decoction (48%). The plant professionals of Togo have diversified knowledge on biodiversity and its  therapeutic virtues.
Activité analgésique et phytochimie des extraits aqueux du fruit de Dacryodes edulis (G. Don) H. J. Lam. (Burseraceae) chez la souris
Authors: Ossibi G.J. Etou , Ossibi A.W. Etou , Mpika J. , Lingomo B.S. Wossolo , Attibayeba
Published: September 2023

Le safoutier (Dacryodes edulis (G. Don) H.J. Lam est un arbre fruitier oléifère de la famille des Burseraceae et ses fruits comestibles sont  appelés safous. L’évaluation des teneurs en flavonoïdes totaux, en polyphénols totaux et en tanins totaux dans les mésocarpes et dans  les graines de fruits à maturité gustative a été faite à partir des dosages au spectrophotomètre. L’activité antalgique des extraits aqueux  de la pulpe et des graines de fruits Dacryodes edulis à maturité gustative a été évaluée chez la souris sur la douleur induite par l’acide  acétique 0,6%. Les résultats obtenus ont révélé la richesse de des fruits de safoutier en ces composés qui s’accumulent dans la graine et  dans le mésocarpe. L’extrait aqueux de la graine est plus riche en composés phénoliques que celui du mésocarpe contre 1456 à 862 mg  EG/gE pour les flavonoides totaux, 698 à 238 mg EQ/gE en polyphénols totaux et 701 à 578 mg EQ/gE en tanins totaux. Concernant  l’activité antalgique, il ressort que les extraits aqueux des deux parties du fruit de safoutier réduisent significativement le nombre de  crampes abdominales chez la souris. L’activité analgésique est due à la présence dans les fruits de D. edulis des composés phénoliques
Efficacy of dexmedetomidine in the prevention and treatment of postanesthetic shivering after cesarean section
Authors: Wang Yi , Zhang Xianjie
Published: September 2023

Purpose: To assess the efficacy of dexmedetomidine in the prevention and treatment of postanesthetic shivering in cesarean section.Methods: A total of 144 pregnant women who underwent anesthesia for cesarean section between March and December 2022 were randomly divided into the study group (n = 72) and control group (n = 72). The pregnant women were given combined spinal-epidural anesthesia. Following childbirth, those in the study group were given dexmedetomidine, while those in the control group were given normalsaline. The dose of spinal anesthesia was administered based on the following criteria: intraoperative infusion, atropine usage, ephedrine usage, intraoperative bleeding, intraoperative dosage, mean arterial pressure, heart rate, blood oxygen saturation, incidence of shivering, and sedation score. Incidence of adverse reactions were recorded and compared between the two groups.Results: Intraoperative infusion volume, bleeding volume, levels of atropine and ephedrine usage, and spinal anesthesia dose were similar between the two groups (p > 0.05). At 10 min post-treatment, the study group had lower mean arterial pressure, heart rate and incidence of postanesthetic shivering, as well as higher postoperative sedation score than the control group. Compared with the control group, the study group had slightly higher incidence of pregnancy-related adverse reactions, but the difference was non-significant.Conclusion: Dexmedetomidine has good efficacy in preventing and treating postanesthetic shivering in cesarean section patients. However, further clinical trials are required prior to its adoption in clinical practice.
Atractylenolide promotes trophoblast cell proliferation and migration in recurrent spontaneous abortion via ERK pathway
Authors: Lv Beili , Wang Haiyan , Li Xinrong
Published: September 2023

Purpose: To investigate the effect of atractylenolide on recurrent spontaneous abortion (RSA).Methods: The HTR-8/SVneo was established as an in vitro cell model of RSA. Cell viability and proliferation were determined using CCK8 and BrdU staining, while cell migration and invasion were determined by cell scratch and transwell assays.Results: Atractylenolide significantly increased cell viability, and enhanced the number of BrdU-positive cells of HTR-8/SVneo (p < 0.01). Atractylenolide also significantly promoted cell migration and invasion (p < 0.01), and increased protein expression of MMP-9, MMP-2, and N-cadherin, but reduced Ecadherin. Atractylenolide also increased the phosphorylation of ERK (p < 0.01).Conclusion: Atractylenolide enhances cell proliferation and migration of HTR-8/SVneo through activation of ERK signaling. Further studies using animal models are recommended to determine the protective role of atractylenolide against RSA, in vivo.
Retracted: Development of a hydrogel containing metronidazole-loaded Eudragit RS 100 nanoparticles for buccal drug delivery
Authors: Ho Hoang Nhan , Nguyen Van Anh Tuan , Ho Nguyen Anh Thu , Le Hoang Hao
Published: September 2023

This article previously published in Volume 22 Issue 6 of this journal in June 2023 has been retracted in line with the guidelines from the Committee on Publication Ethics (COPE, http://publicationethics.org /resources /guidelines). This was a follow up to the report by somebody identified as VU Nguyen (email: nguyenvu81@protonmail.com)  of the duplicate publication of an article earlier published in 2020 (available at http://125.212.201.8:6008 / ViewOnline?bitstid=0d585588-2d02-4839-907a-92998674bb4d & type=1) in Vietnamese where a figure and some text in the article were repeated in the article published in this journal.

This action was taken after thorough investigation of the plagiarism report and follow-up comments from both the corresponding author and Nguyen VU against the guidelines of the Committee on Publication Ethics (COPE).

Retraction: Ho HN, Nguyen VA, Ho NA, Le HH. Development of a hydrogel containing metronidazole-loaded Eudragit RS 100 nanoparticles for buccal drug delivery. Trop J Pharm Res 2023; 22(6):1147- 1154 doi: 10.4314/tjpr.v22i6.1.
Sanggenon C inhibits proliferation of breast cancer cells and reduces HIF-1α/VEGF pathway activity under hypoxia conditions
Authors: Qu Junyuan , Li Jing , Ma Yongqiang , Wang Zhihui
Published: September 2023

Purpose: To evaluate the function and mechanism of sanggenon C (SC) on breast cancer (BC) cells.Methods: The effect of SC on malignant processes of BC was studied through cell counting kit-8, colony formation, flow cytometry, Transwell, wound-healing and western blot experiments. Besides, the related mechanism of action was explored using western blot assay.Results: SC reduced the cell viability of MDA-MB-231 and MCF-7 cells with half-maximal concentration of (IC50) value of 17.09 and 17.32 μM, respectively. SC also decreased the area ratio of colonies in the plate, but increased the apoptosis and G0/G1 phase arrest in both cell lines. Furthermore, SC decreased the number of invasion cells, but elevated the relative wound width of both cells. Moreover, SC treatment neutralized the hypoxia-induced level of HIF-1α/VEGF signaling.Conclusion: SC suppresses proliferation, mobility and invasion, but induces apoptosis and G0/G1 phase arrest in BC cells, as well as deceased HIF-1α/VEGF pathway activity under hypoxia conditions. The findings of this study reveal that SC is a potential agent for BC management.
Qibai Pingfei capsule induces apoptosis of pulmonary artery smooth muscle cells in hypoxic rats by regulating PI3K/AKT/mitochondrial signaling pathway
Authors: Tong Xiangli , Zhang Lu , Zhu Jie , Li Zegeng
Published: September 2023

Purpose: To investigate the effect of Qibai Pingfei capsules (QBPF) medicated serum on the apoptosis of rat pulmonary artery smooth muscle cells (PASMC) in hypoxic rats, and to determine the relationship between that effect and PI3K/Akt/mitochondrial apoptosis pathway.Methods: Rat PASMCs were isolated, cultured, and the optimal hypoxic time and concentration of QBPF were determined by CCK-8 method. Hypoxic rats were treated with QBPF, QBPF + LY294002, or QBPF + SC79. Apoptosis and mitochondrial membrane potential were assessed using Annexin VFITC/ PI, Hoechst 33258, and Rho123 staining. The protein expression levels of AKT, P-AKT, and apoptosis-related proteins were evaluated via western blot.Results: CCK-8 studies showed that the optimal hypoxic time was 24 h, while the optimal concentration of QBPF was 20 %. Annexin V-FITC/PI double staining and Hoechst 33258 assay revealed that QBPF significantly promoted the apoptosis of PASMCs in hypoxic rats (p < 0.05). Rho123 test results showed that QBPF inhibited mitochondrial membrane potential level in hypoxic rats' PASMCs, which was enhanced by PI3K inhibitor LY29002 and inhibited by AKT agonist SC79 (p < 0.05). Western blot showed that QBPF reduced the protein level of P-AKT and Bcl-2, and raised the protein levels of Bad, Bax, CytC, casepase-9 and casepase-3, which was enhanced by LY29002 and blocked by SC79 (p < 0.05). No major changes in AKT protein expression were seen between the groups.Conclusion: In hypoxic rats, QBPF blocks PI3K/AKT signaling pathway and regulates the activation of downstream Bcl-2 family members, thus activating mitochondrial apoptosis pathway and triggering PASMC death.
Alfabetización para la salud del personal técnico en cuidados auxiliares de enfermería y del personal no sanitario perteneciente a la plantilla laboral de cuatro hospitales españoles
Authors: Cabanillas-Franco Ana , Hernández-Blázquez Alba , Mendoza-Aragón Raquel , Suárez Fernández María Victoria , Sanz-Valero Javier
Published: September 2023

Objetivo: Estimar el grado de alfabetización para la salud (AS) de las técnicas en cuidados auxiliares de enfermería (TCAE) y del personal no sanitario perteneciente a la plantilla laboral de 4 hospitales españoles.
Método: Estudio descriptivo-correlacional, siendo la población diana las TCAE a quienes se preguntó, mediante formulario online HLS-EU-Q16 (Health Literacy Survey - European Union), con escala Likert de 4 valores (de 1 muy fácil a 4 muy difícil). 
Resultados: Respondieron 477 profesionales. Los resultados para la AS global fueron: media 1,95 ± 0,03 y mediana 1,94. El nivel de alfabetización en salud (NAS) demostró AS suficiente en 293 (61,43%) individuos. La mediana sobre la AS de los 3 componentes del cuestionario fue: cuidado sanitario = 2, prevención de enfermedades = 2 y promoción de la salud = 1,75. El ítem sobre sobre la manera de abordar problemas de salud mental es el que presentó mayor dificultad con media de 2,45 ± 0,04 y mediana igual a 2. No hubo diferencias significativas entre TCAE y el personal no sanitario.
Conclusiones: El grado de AS de las TCAE resultó ser bueno, tanto a nivel global como en las dimensiones de atención y cuidado sanitario, prevención de enfermedades y promoción de la salud. Asimismo, el nivel de alfabetización en salud que se obtuvo resultó ser suficiente en la mayoría de ellas. No se encontró diferencias con el personal no sanitario perteneciente a la plantilla laboral de 4 hospitales estudiados.
Editorial (Vol 15, Trimestre 2, 2012)
Authors: Rollán de la Sota Mª Jesús
Published: September 2023

Estamos a punto de iniciar las tan ansiadas vacaciones estivales, las cuales nos servirán sin duda, para descansar y cargarnos de fuerza y así enfrentar el otoño con ganas. Nos harán falta, porque nuestros pacientes nos necesitaran fuertes y serenas, en estos tiempos tan difíciles del sistema sanitario. Han pasado casi tres años de nuestra andadura como Junta Directiva de la SEDEN. Parece mentira, pero este congreso de Ávila será el tercero. Todos conocéis que las nuevas candidaturas a la Junta Directiva de la SEDEN deben presentarse antes del 15 de julio; os animo a ello. Y os aliento desde el convencimiento que vale la pena. Una sociedad tan vital e imprescindible como la nuestra, se merece que alguno de vosotros apostéis por dirigirla presentando vuestra solicitud, estoy segura que alguna candidatura deseara implicarse. La SEDEN es un buen vehiculo para facilitar la comunicación, acreditar nuestra formación y trasmitir nuestras aspiraciones a otras instituciones, pero para que su fortaleza sea efectiva no solo ha de tener muchos asociados sino que éstos participen con dinamismo.
Technologies of Care. From Sensing Technologies to an Aesthetics of Attention From Sensing Technologies to an Aesthetics of Attention in a More-than-Human World
Authors: Volkart Yvonne
Published: September 2023

In the art of the last decade, a relational, cross-species turn has taken place—a techno-eco-feminist turn toward the environmental, toward ontologies of becoming-together and caring for the Earth. It is a new sensibility toward planet Earth’s grounding on physical forces, in the midst of the total technologization of the world. This eco-sensibility is based on technologies, practices, and aesthetics in art that enable, poeticize, celebrate, and deploy paying attention to the more-than-human as a political practice of desire and counterappropriation of dispossessed worlds––in short, Technologies of Care. In this process, technical means and data play an essential role; especially as they come with the hope that, on the one hand, measuring data can be used to render the factuality of unknown or denied environmental phenomena and, on the other hand, that they generate new forms of attention toward the environment. The author claims, though, that the potential of technologies of care is to be sought less in the use of innovative technologies and well-intentioned themes than in the enabling of aesthetic experiences of co-existence with earthly beings, and their difference and foreignness. Her argumentation is based on the in-depth analysis of exemplary artistic projects; many of them are in the interdisciplinary field of art and science––an ideal site for strange encounters, and processes of mutual translation and distortion. The value of artistic practices, she states, does not lie in the visualization and transposition of abstract data into a language that touches. Rather, it lies in trans-making things, and in the disturbing effects that such acts of disfiguring trigger: the creation of cross-species commonalities instead of the othering which prevails in the dominant discourse.
Juvenil idiopatik artritli çocuklarda komorbid hastalıkların analizi ve hastalık sürecine etkisi
Authors: ŞAHİN Nihal , ASADOVA Sevda , TAŞKIN Sema Nur , DOĞANTAN Şeyda , ÖZDEMİR ÇİÇEK Sümeyra , PAÇ KISAARSLAN Ayşenur , POYRAZOĞLU Hakan
Published: September 2023

Amaç:

Komorbiditeler bir indeks hastalığın seyrinde var olan ya da sonradan ortaya çıkan durumlar olarak tanımlanır. Kronik hastalıklarda eşlik eden komorbidite varlığı hastalık sürecine etki edebilir. Juvenil idiopatik artrit (JİA) çocukluk çağının nedeni belli olmayan kronik artritidir. Bu çalışmada JİA hastalarında eşlik eden komorbiditeleri incelemek ve hastalık seyrine etkilerini araştırmak amaçlandı.

Araçlar ve Yöntem:

2005-2021 yıllarında merkezimizde takip edilen ILAR kriterlerine göre JİA tanısı almış 18 yaş altındaki hastalar dahil edildi. JİA’ya eşlik eden tıbbi dosyalara kaydedilmiş tüm ek hastalıklar komorbidite olarak değerlendirildi. Komorbidite eşlik eden ve etmeyen hastalarda JİA hastalık aktivite (JADAS27, JSPADAS), hasar (JADI-A, JADI-E) ve sağlık değerlendirme anket (CHAQ) skorları ve JİA tedavileri karşılaştırıldı.

Bulgular:

Çalışmada 204 hasta vardı. Hastaların yaş ortanca değeri 13 (4-17,5) yıl, takip süresi ortanca değeri 5 (2-16) yıl idi. Hastaların 99’unda (%48,5) en az bir komorbidite saptandı. Birden fazla komorbidite saptanan hasta sayısı 24 (%11,8) idi. En sık saptanan komorbidite AAA (n=31 (%15,2)) idi. Ardından 23 (%11,3) hastada üveit vardı. JADAS 27, JSPADAS skorları komorbidite varlığına göre farklılık göstermedi (sırasıyla, p=0,55, p=0,63). İki grup arasında JADI-A, JADI-E skorlarında farklılık yoktu (sırasıyla, p=0,45, p=0,11). CHAQ skoru da komorbidite olanlarda farklı değildi (CHAQ disability: p=0,62; CHAQ discomfort: p=0,61; CHAQ pain: p= 0,32). Biyolojik ilaç kullanımı komorbidite olanlarda 42 (%42,4), olmayanlarda 43 (%41) idi (p=0,83). Adalimumab kullanımı komorbidite eşlik edenlerde daha fazlaydı (Komorbidite olanlarda: n=22 (%22,2); olmayanlarda: n=11 (%10,5); (p=0,02)).

Sonuç:

Komorbidite varlığının hastalık aktivite, hasar ve sağlık değerlendirme anket skorlarına etkisi saptanmamasına rağmen komorbidite varlığına göre JİA tedavi seçimi değişmektedir.
LİTYUM TESTİNİN ÖLÇÜM BELİRSİZLİĞİNİN DEĞERLENDİRİLMESİ
Authors: POLAT Cemal
Published: September 2023

AMAÇ: Laboratuvarımızda lityum testinin ölçüm belirsizliğini hesaplamak ve uluslararası kuruluşların belirlediği % total izin verilen hata (%TEa) değerleriyle karşılaştırmaktır.

ARAÇLAR VE YÖNTEM: Çalışma 01 Ocak 2021 – 30 Eylül 2021 tarihleri arasını kapsamaktadır. Veriler laboratuvar bilgi sisteminden geriye dönük olarak elde edildi. Laboratuvarımızda lityum testi serum numunesinde Siemens ADVIA 2400 otonalizöründe spektrofotometrik yöntemiyle analiz edilmektedir. Lityum testinin ölçüm belirsizliği Nordtest teknik raporu 537’ye göre hesaplandı.

BULGULAR: Çalışmamızda lityum testi için iç kalite kontrol belirsizlik değeri %4.37, dış kalite kontrol belirsizlik değeri %2.093 ve genişletilmiş belirsizlik değeri ise %95 güven aralığında %13.92 olarak tespit edildi.

SONUÇ: Çalışmamızda lityum testinin ölçüm belirsizliği CLIA’88’nın belirlediği %TEa değerine göre kabul edilebilir düzeyde bulunmuştur. Fakat Rilibak’ın belirlediği %TEa değerine göre ise kabul edilebilir düzeyinin dışında tespit edilmiştir. Lityum testi başta olmak üzere laboratuvar testlerimizin kalite standartlarının artırılması düşünüldü. Laboratuvarlarda testlerin ölçüm belirsizliğinin hesaplanması ve gerektiğinde ulaşılabilir olması laboratuvarların kalitesinin artmasına ve klinisyenlerin hastalarına yönelik klinik karar süreçlerine yardımcı olabilirler.
SAĞLIKLI GENÇ YETİŞKİNLERDE SERVİKAL PROPRİOSEPSİYON DUYUSU İLE SERVİKAL BÖLGE EKLEM HAREKET AÇIKLIĞI VE POSTÜR ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: ÖZÜDOĞRU Anıl , CEYLAN İsmail , CANLI Mehmet , KUZU Şafak
Published: September 2023

Amaç: Bu çalışma, sağlıklı genç yetişkinlerde servikal bölge propriosepsiyon duyusu ile servikal bölge eklem hareket açıklığı ve postür arasında ilişki olup olmadığını araştırmak amacıyla yapıldı.

Gereç ve Yöntemler: Bu çalışma, Kırşehir Ahi Evran Üniversitesi Fizik Tedavi ve Rehabilitasyon Yüksekokulu’nda 98 sağlıklı genç yetişkin üzerinde yapıldı. Çalışmaya katılan bireylerin servikal propriosepsiyon duyuları 4 farklı pozisyonda (fleksiyon, ekstansiyon, sol rotasyon ve sağ rotasyon) Servikal Eklem Pozisyon Hata Testi ile değerlendirildi. Ayrıca çalışma katılımcılarının postürleri New York Postür analizi ile servikal bölge eklem hareket açıklığı değerleri ise manuel bir gonyometre ile değerlendirildi. Parametrelerin birbiri ile ilişkisi Pearson Korelasyon Analizi kullanılarak incelendi.

Bulgular: Çalışmaya katılan bireylerin yaş ortalaması 20.85±1.68’di. Servikal bölge propriosepsiyon alt parametreleri değerleri ile New York Postür Analizi ve servikal bölge eklem hareket açıklığı alt parametreleri arasında herhangi bir istatistiksel anlamlı bir ilişki bulunmadı (p>0.05).

Sonuç: Servikal propriosepsiyonun postür ve servikal bölge eklem hareket açıklığı ile ilişkili olmadığı sonucuna ulaşıldı. Ancak servikal propriosepsiyon duyusu ile eklem hareket açıklığı ve postürün servikal bölge patolojisine sahip olanlarda incelenmesi gereğini düşünmekteyiz.
Fuzzy Logic for Solving Differential Equations in Physics
Authors: Raju M.S
Published: September 2023

This study explores the application of fuzzy logic as a powerful tool for solving differential equations in the domain of physics. Two case studies, the quantum mechanical harmonic oscillator and the classical damped harmonic oscillator, serve as illustrative examples of how fuzzy logic can address uncertainties and imprecision’s inherent in these physics’ problems. The findings highlight the adaptability and robustness of fuzzy solutions, bridging the gap between deterministic models and complex real-world systems. The study also proposes future research directions to further advance the field of fuzzy differential equations in physics.
REALISME MAGIS SEBAGAI REPRESENTASI KRITIK KEADAAN DALAM MANUSIA KELELAWAR KARYA DAMHURI MUHAMMAD
Authors: Dhiya Ulhaq Salma
Published: September 2023

Indonesian people are one of many eastern countries that still believe in the tradition of honoring their ancestors, therefore people still believe in mystical things. This has led some writers to use people's 'trust' in mysticism in their literary works. This article provides insight into how Wendy B. Faris' magical realism theory can be applied in the analysis of fictional stories. by analyzing magical realism in the selected short story by Kompas, “Bat Man” Damhuri Muhammad in 2022, through magical realism elements; (a) irreducible elements; (b) world phenomenal; (c) dimensions of the amalgamation; (d) unsetting doubts; and (e) disruption of time, space and identity in short stories. The five seek to establish a connection between real and magical life through the boundaries between the elements that have been broken. The use of this theory helps broaden the understanding of magical realism as a literary approach that allows social criticism through magical representations of complex social situations. The results of the study found that the 'bat man' who died horribly in this story represents the situation towards the hunting of bats that caused the spread of the virus, showing the arrogance of humans who seem to be brutal towards other living things.
Keywords: Critique of Circumstances; Bat-Man; Magical Realism; Wendy B. Farris
A Comparative Clinical Study on Effect of Agnikarma and Siravedha in Vata Kantaka w.s.r Plantar Fasciitis
Authors: A. Bhuvaneshwar  , K. Srinivasa kumar
Published: September 2023

Vatakantaka causes very severe pain in heal region. Vata gets aggravated and localised in Khudapradesha when person walks on unevenly or irregularly on surface. It causes difficulty to daily regular activities. It can be compared to Plantar Fasciitis as there will be stabbing (Kantaka) type of pain. Incidence is about 10% of the population, about 83% of these patients being actively working between age of 25-60 years. There is only conservative management for short term relief with certain draw backs and surgical management which increase hospital stay and high economical expenses. Acharya Sushruta described Agnikarma painful condition of Twak, Mamsa, Sira, Snayu, Asthi Sandhi. Sushruta also mentioned Siravedha of vein situated two Angulas (4cm) above the Kshipramarma in Vatakantaka. The study is aimed to compare efficacy of Agnikarma and Siravedha in Vatakantaka w.s.r plantar fasciitis. A total of 40 patients are selected and randomly divided into two groups, Group A Agnikarma in 20 patients and Group B Siravedha in 20 patients. Both group given relief in symptoms of Vatakantaka. Group A - Agnikarma (90.53%) and group – B Siravedha (88.31%) were significant in treating Vatakantaka. But Agnikarma is better effect then Siravedha in management of Vatakantaka. Both therapies can be done with less economical expenditure and minimum hospitalization.
A Successful Clinical Case Study on Management of Visarpa
Authors: Prabhu.K.bhairaji  , Venkatesh Polampalli
Published: September 2023

“Visarpa” is one of the most common skin disorder which explained in Ayurveda. It is one of the most common disease suffering in present era. The Visarpa which is an active transmitting viral disease causing painful skin rash with acute onset blisters in localised areas. Visarpa is predominantly involved Pitta dosha due to Pitta drava and Sara guna more which spreads easily all over the body. Viral syndrome caused by oraganism named as “varicella zoster”. Incidence of herpes zooster ranges from 3.9 to 11.8 per 1000 person per year. Reoccurrence are most common in patients who is immuno-suppressed. The treatment planned Raktamokshan specially jaloukavacharana which gives very effective results in Visarpa vyadhi. Result of the treatment observed on the basis of improvement in sign and symptoms of Visarpa were found completely healed within 1 week of treatment the detailed case is presented in the following content.
A Case Study on Bells Palsy and its Ayurvedic Management
Authors: Prerna  , Neetu Tegta
Published: September 2023

Bell’s palsy is a neurological disorder of seventh cranial nerve which leads to unilateral facial paralysis. A complete interruption of the facial nerve at stylomastoid foramen paralyses all muscles of facial expression. In Ayurveda it can be compared with Ardita, which is Vata Nanatmaja Vyadhi. Different Acharya attributed root cause of Ardita to highly vitiated Vata dosha but some also explained the involvement of other Dosha in disease manifestation. Acharya explained causes of Ardita like transferring heavy wt on head, excessive laughing, loudly talking, sudden fearing, sleeping on uneven bed, eating hard food particles other Vatavardhak ahara vihara leads to vitiation of Vata dosha. This is a case study of a 37-years old female; she came to Kayachikitsa OPD with the complaints of deviation of mouth to left side, numbness in right side of face, feeling of swelling in the lower lip and was unable to completely close her right eye. Diagnosis of the patient was made by typical presentation and with neurological (especially cranial nerve) examination. Lab investigations were not indicative of any underlying pathology. The patient treatment included facial muscle strengthening exercises, eye protection measures and eye drops, Nasya with Anu taila and Ayurvedic formulations. Referrals were made in Panchkarma dept. for regular Nasya and Dhoompan. Patients got discharged after some recovery in symptoms and in few months with regular follow up patient showed marked improvement in symptoms.