bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Faktor yang Berhubungan dengan Pelaksanaan IMD
Authors: Herlinda Evi , Aryawati Wayan , Yanti Dhiny Easter , Bustami Anita , Angelina F Christin
Published: April 2024

Inisiasi Menyusu Dini (IMD) merupakan proses bayi menyusu segera setelah dilahirkan, dimana bayi dibiarkan mencari putting susu ibunya sendiri yang dilakukan sekurang-kurangnya satu jam segera setelah lahir. Secara nasional persentase bayi baru lahir yang mendapat IMD adalah 82,7%, Kabupaten Lampung Utara mencapai 95,1%, dan di RSD Mayjend HM. Ryacudu hanya 33,04% ibu yang berhasil melakukan IMD. Tidak berhasilnya pelaksanaan IMD dapat memberi dampak meningkatkan tingginya angka mortalitas dan morbiditas. Tujuan penelitian ini untuk mengetahui faktor yang berhubungan dengan pelaksanaan IMD di RSD Mayjend HM. Ryacudu Kabupaten Lampung Utara tahun 2023. Jenis penelitian kuantitatif dengan rancangan cross sectional. Populasi adalah seluruh ibu bersalin di RSD Mayjend HM. Ryacudu Kabupaten Lampung Utara pada bulan Februari-Maret tahun 2023 dengan jumlah 93 orang. Sampel dalam penelitian ini menggunakan total sampling yaitu 93 orang. Instrument penelitian yang digunakan adalah kuesioner dan lembar observasi. Analisis data dalam penelitian menggunakan univariat, bivariat (chi-square), dan multivariat (regresi logistic berganda). Hasil penelitian ini menunjukkan bahwa ada hubungan pendidikan (p value 0,040 dan OR 2,630), jenis persalinan (p value 0,005 dan OR 3,860), pengetahuan (p value 0,027 dan OR 2,856), sikap (p value 0,020 dan OR 2,951), dan dukungan tenaga kesehatan (p value 0,000 dan 5,438) dengan pelaksanaan. Tidak ada hubungan paritas (p value 0,427) dan dukungan keluarga (p value 0,138) dengan pelaksanaan IMD. Faktor dominan yang paling berhubungan dengan pelaksaan IMD adalah variabel jenis persalinan dengan OR 12,535. Saran ibu bersalin baik secara sectio caesarea ataupun pervaginam dapat berperan aktif dalam melakukan IMD, selain itu ibu juga dapat mencari informasi baik dari media cetak ataupun media online.
Imaginea de 3 vase şi trahee – marker important în anomaliile de vase mari
Authors: Comănescu Maria Cristina , Comănescu Alexandru  Cristian , Iliescu Dominic , Drăguşin Roxana Cristina , Popa Aura-Iuliana
Published: April 2024

Congenital heart malformations are the most common cause of fetal and infant mortality, with an incidence of 4-13 per 1000 live births. Antenatal ultrasound evaluation of the fetal heart has developed over the past 30 years, and has allowed the detection of many abnormalities in the first trimester of pregnancy. Prenatal screening for fetal mal­for­ma­tions is mandatory, allowing a better preg­nan­cy coun­­se­ling and greatly improving the neonatal prog­no­sis. According to the Romanian Society of Obstetrics and Gynecology (SOGR), the evaluation of the fetal heart start­ing from the first trimester of pregnancy is mandatory. Due to technological advances, the fetal heart can be as­ses­sed in detail as early as the first trimester, which al­lows for adequate counseling of the couple facing a mal­for­ma­tive heart pathology in their fetus, allows the ter­mi­na­tion of pregnancy at a legally optimal gestational age, or, when the ultrasound assessment does not reveal any fetal malformation, it assures the couple about the normal course of the pregnancy. The evaluation of the fetal heart using standard plans of examination is per­formed in each tri­mes­ter of pregnancy. We present a series of cardiac mal­for­ma­tions detected antenatally in our clinic, using stan­dard assessment views. The purpose of this study is to em­pha­size that most lesions involving the ejection tracts of the ar­te­ries at the base of the heart are associated with varying de­grees of disruption of the alignment, arrangement, size, or number of the three vessels, thus with an abnormal ap­­pea­rance of the stan­dard cross-section of three vessels. In all cases, the three-vessel view of the heart revealed an abnormal ap­pea­rance, helping us to diagnose major car­diac mal­for­ma­tions. This plan can be easily obtained in all tri­­mes­ters of pregnancy, providing sufficient information to de­tect many major conotruncal malformations.
HTLV: un nou subiect pentru screeningul prenatal?
Authors: Anghel Alina-Irina , Durdu Cristiana-Elena , Bohîlţea Roxana-Elena
Published: April 2024

Human T-cell leukemia virus-1 (HTLV-1) is the first infectious agent proven to cause cancer, and it is considered among the most potent carcinogens for humans. HTLV-1 is esti­ma­ted to have infected 5-10 million individuals, with only about 5% of people that contract the virus expected to de­velop any associated disease. Within Europe, Romania ap­pears to be the only region endemic to HTLV-1. There are two primary diseases associated with HTLV-1, T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM), or tropical spastic paraparesis (TSP). Each is linked to a dis­tinct mode of transmission: ATL with breastfeeding, and HAM/TSP with blood transfusion. The main ways of viral trans­mis­sion are from mother to child by breastfeeding, via blood transfusions, or through sexual intercourse. Vertical in­fec­tion rate has been found to be 14.2%. In Romania, HTLV is included in the screening for blood donors, but not in prenatal screenings. Vertically transmitted infections can be reduced with up to 87% by avoiding breastfeeding. New re­search supports the effectiveness of prenatal screening fol­lowed by avoiding breastfeeding in reducing new cases of HTLV in endemic areas, and such measures must be taken in Romania as well.
Diagnosticul diferenţial ecografic al defectelor de perete abdominal fetal în primul trimestru de sarcină
Authors: Poenaru Mircea  Octavian , Bogheanu Delia-Maria , Sima Romina-Marina , Pleș Liana
Published: April 2024

Fetal abdominal wall defects (AWDs) refer to a variety of congenital anomalies characterized by the incomplete clo­sure or disruption of the abdominal wall in the early stages of embryonic development. Based on the 2011 Euro­pean Surveillance of Congenital Anomalies (EUROCAT) re­port, the general prevalence of fetal abdominal wall de­fects is documented to be six cases per 10,000 births. AWDs pose significant challenges for prenatal diagnosis and manage­ment. Ultrasound has emerged as an indispensable tool in diagnosing and characterizing various abdominal wall defects early in pregnancy, enabling precise prenatal coun­seling and appropriate antenatal management stra­te­gies. This article provides a general review of the spe­cia­lized literature regarding various types of abdominal wall de­fects, such as omphalocele, gastroschisis, pentalogy of Cantrell, bladder exstrophy, and limb body wall complex, high­lighting the significant sonographic features observed du­ring ultrasound examination. Additionally, differential diag­noses are explored, emphasizing the importance of ac­cu­rately distinguishing between these conditions to en­sure optimal management strategies. This article aims to en­hance the understanding and familiarity of ultrasound prac­ti­tio­ners and obstetricians with the spectrum of fetal ab­do­mi­nal wall defects and their prenatal sonographic ap­pea­rance, thus facilitating improved prenatal care and patients’ counseling.
Characterization of the bottlenecks and pathways for inhibitor dissociation from [NiFe] hydrogenase
Authors: Sohraby Farzin , Nunes Alves Ariane
Published: April 2024

[NiFe] hydrogenases can act as efficient catalysts for hydrogen oxidation and biofuel production. However, some [NiFe] hydrogenases are inhibited by gas molecules present in the environment, such as O2 and CO. One strategy to engineer [NiFe] hydrogenases and achieve O2 and CO-tolerant enzymes is by introducing point mutations to block the access of inhibitors to the catalytic site. In this work, we characterized the unbinding pathways of CO in complex with the wild type and 10 different mutants of [NiFe] hydrogenase from Desulfovibrio fructosovorans using τ-Random Accelerated Molecular Dynamics (τRAMD) to enhance the sampling of unbinding events. The ranking provided by the relative residence times computed with τRAMD is in agreement with experiments. Extensive data analysis of the simulations revealed that, from the two bottlenecks proposed in previous studies for the transit of gas molecules (residues 74 and 122, and residues 74 and 476), only one of them (residues 74 and 122) effectively modulates diffusion and residence times for CO. We also computed pathway probabilities for the unbinding of CO, O2 and H2 from the wild type [NiFe] hydrogenase and we observed that, while the most probable pathways are the same, the secondary pathways are different. We propose that introducing mutations to block the most probable paths, in combination with mutations to open the main secondary path used by H2, can be a feasible strategy to achieve CO and O2 resistance in the [NiFe] hydrogenase from Desulfovibrio fructosovorans.
[45Ti]Ti-DOTA: En route towards aza-macrocyclic 45Ti-based radiopharmaceuticals
Authors: Roy Tamal , Pogorilyy Eduard , Kumarananthan Chubina Pathma , Kvitastein Unni Augestad , Foscato Marco , Törnroos Karl Wilhelm , Adamsen Tom Christian Holm , Le Roux Erwan
Published: April 2024

We report the first use of DOTA as a chelator for titanium. The resulting complex is fully characterized and extended to the radiolabelling of DOTA with titanium-45.
WS24: A diverse data set for predicting metal-organic framework stability in water and harsh environments with data-driven models
Authors: Terrones Gianmarco , Huang Shih-Peng , Rivera Matt , Yue Shuwen , Hernandez Alondra , Kulik Heather
Published: April 2024

Metal-organic frameworks (MOFs) are porous materials with applications in gas separations and catalysis, but a lack of water stability often limits their practical use given the ubiquity of water in air and the environment. Consequently, it is useful to predict whether a MOF is water-stable before investing time and resources into synthesis. Existing heuristics for designing water-stable MOFs lack generality and artificially limit the diversity of explored chemistry due to narrowly defined criteria. Machine learning (ML) models offer the promise to improve generality of predictions but require diverse experimental MOF stability data to be trained. In an improvement on previous efforts, we enlarge the available training data for MOF water stability prediction by over 400%, adding 911 MOFs with water stability labels assigned through semi-automated manuscript analysis to curate the new data set WS24. The additional data is shown to improve ML model performance (test ROC-AUC > 0.8) over diverse chemistry for the prediction of both water stability and stability in harsher acidic conditions. We illustrate how the expanded data set and models can be used with previously developed activation stability models to carry out genetic algorithms to quickly screen ~10,000 MOFs from a space of hundreds of thousands for candidates with multivariate stability (i.e., for activation, in water, and in acid). Model analysis and genetic algorithm results uncover metal- and geometry-specific design rules for robust MOFs. The data set and ML models developed in this work, which we disseminate through an easy-to-use web interface, are expected to contribute toward the accelerated discovery of novel, water-stable MOFs for applications such as direct air gas capture and water treatment.
Evaluation performance to assess accurate exchange-correlation functional in van der Waals TMD Materials AB2 (A = Mo, W and B = S, Se and Te)
Authors: Behera Sushant Kumar , Ramamurthy Praveen C
Published: April 2024

Two-dimensional (2D) transition metal dichalcogenides (TMDs) show multi-functionality due to their highly adjustable chemical, physical, and electronic properties. Here, structural, electronic, and phonon response are systematically studied for 06 TMDs systems via density functional theory (DFT) simulations. A reversible phase transition is revealed between the semiconducting (2H) phase and the metallic (1T) phase in the stable phases of these TMD systems. Precisely, group-VI TMDs (AB2, A = Mo, W and B = S, Se, Te) are focused in this present calculations. Their electronic behavior is assessed to check the accuracy of few available exchange-correlation (XC) functional, along with van der Waals density functional (vdW-DFs). Here, both spin-orbit coupling (SOC) effects and no SOC (NSOC) cases are considered during the calculations. Changes observed in the electronic band structure and density of states for the 2H and 1T phases are worth noticing, which highlights their potential capabilities for conventional device functionalities. These observations not only enable to find the most accurate XC functional, but also shed light on the potential functionalities of these TMDs materials.
Auto-VTNA: An Automatic VTNA platform for Determination of Global Rate Equations
Authors: Dalland Daniel , Schrecker Linden , Hii King Kuok (Mimi)
Published: April 2024

The ability and desire to generate kinetic data has greatly increased in recent years, requiring more automated and quantitative methods for analysis. In this work, an automated program (Auto-VTNA) is developed, to simplify the kinetic analysis workflow. The Auto-VTNA solver allows all the reaction orders to be determined concurrently, expediting the process of kinetic analysis. Auto-VTNA performs well on noisy or sparse data sets and can handle complex reactions involving changing reaction orders. Quantitative error analysis and facile visualisation allows users to numerically justify and robustly present their findings. Auto-VTNA can be used through a free graphical user interface (GUI), requiring no coding or kinetic knowledge from the user, or can be customised and built on if required. The code and executable application ("Auto-VTNA Calculator") can be found at https://github.com/ddalland/Auto-VTNA.
Albumin Nanoparticles in Cancer Therapeutics: Clinical Status, Challenges, and Future Directions
Authors: KADRI HACHEMI , Alshatfa Mesk , Alsalloum Feras Z , Elhissi Abdelbary , Daou Anis , Khoder Mouhamad
Published: April 2024

Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design to enable targeted drug delivery, nanoparticles have presented a promising avenue to overcome these limitations. Protein-based nanoparticles, particularly those based on albumin, are notable for their biocompatibility, stability, and ease of modification. The approval of Abraxane, an albumin-based nanoparticle formulation of paclitaxel, for metastatic breast cancer marked a significant milestone. However, further approvals have been slow to materialize until the recent approval of Fyarro® in 2021. This mini-review highlights the potential of albumin-based nanoparticles, focusing on their advantages, their current state, and progress in clinical use as anticancer therapeutics. We also discuss challenges impeding new approvals and future directions for unlocking the full potential of this technology.
Europium-rich ternary phases with noble metals Eu2M2X (M = Pd, Pt; X = Al, Ga, Ge, Cd), and their structural relationship to the Laves phase Ca2Pt3Al1–xAgx
Authors: Ponou Simeon , Mudring Anja-Verena
Published: April 2024

The combination of divalent Eu with high magnetic moment and strong spin-orbit coupling (SOC) on Pd or Pt atoms in a single substance, makes Eu-Pd/Pt-X ternary phases attractive for materials with exotic physical properties. For that reason, compositions according to Eu2M2X (M = Pd, Pt; X = Al, Ga, Ge, Cd) were explored. X-ray diffraction analyses revealed that the three Pd analogues Eu2Pd2Al, Eu2Pd2Ga, and Eu2Pd2Ge crystallize isostructural to Ca2Pd2Ge, a ternary ordered variant of the Zr2Al3-type (orthorhombic Fdd2). In contrast, Eu2Pt2Al adopts the Ca2Ir2Si type rival structure (monoclinic C2/c). The two structure types are closely related as they both feature linear chains of the noble metals, with the X atoms bridging the metal chains from adjacent layers. However, a striking difference is noticeable within the metal chains: The Pd linear chains consist of equidistant PdPd atoms (2.96 Å), whereas in the Pt chains are pairwise distorted with alternating shorter (Pt–Pt = 2.80 Å) and longer (2.98 Å) contacts. The pairwise distortion is, at first glance, attributed to stronger relativistic influence on Pt atom. In addition, Eu2Pt2Cd, adopts the W2CoB2 type, suggesting that the valence electron count (vec) has strong influence in the structure selection. Finally, both Ca2Pd2Ge- and Ca2Ir2Si-type structures are also discussed as defect Laves phases in connection with the newly discovered phase Ca2Pt3Al1–xAgx (x = 0.13(1)) which adopts the TbFe2 type structure (space group R-3m). DFT first principles electronic band structure calculations, conducted on the Ag-free ordered model “Ca2Pt3Al”, suggested that Ag-inclusion is mainly due to geometric factors, while the chemical bonding picture is consistent with a polar intermetallic system.
Electrolytomics: A unified big data approach for electrolyte design and discovery
Authors: Kumar Ritesh , Canh Vu Minh , Ma Peiyuan , Amanchukwu Chibueze
Published: April 2024

Electrolyte discovery is the bottleneck for developing next generation batteries. For example, lithium metal batteries (LMBs) promise to double the energy density of current Li-ion batteries (LIBs) while next generation LIBs are desired for operations at extreme temperature conditions and with high voltage cathodes. However, there are no suitable electrolytes to support these battery chemistries. Electrolyte requirements are complex (conductivity, stability, safety) and the chemical design space (salts, solvents, additives, composition) is practically infinite; hence discovery is primarily guided through trial-and-error which slows the deployment of new battery chemistries. Inspired by artificial intelligence (AI)-enabled drug discovery, we usher in a new paradigm for electrolyte discovery. We assemble the largest small molecule experimental liquid electrolyte ionic conductivity dataset and build highly accurate machine learning (ML) and deep learning models to predict ionic conductivity across a wide range of electrolyte classes. The developed models outperform molecular dynamic (MD) simulations and are interpretable without explicit encoding of ionic solvation. While most ML-based approaches target a single property, we build additional models of oxidative stability and Coulombic efficiency and develop a new metric called the electrolyte score (eScore) to unify the predicted disparate electrolyte properties. Deploying these models on large unlabeled datasets, we discover new electrolyte solvents, experimentally validate that the electrolyte is conductive (> 1 mS cm-1), stable up to 6V, supports efficient anode-free LMB, and even LIB cycling at extreme temperatures. Our work heralds a new age in electrolyte design and battery materials discovery.
Synthesis and in vitro antibacterial activity evaluation of coumarin-1,3,4-thiadiazoles hybrids
Authors: Ergena Asrat
Published: April 2024

Purpose: Hybridization of two or more potent pharmacophores into a single molecule is one of the current strategies to synthesize compounds with improved pharmacological activity. Coumarin and 1,3,4-thiadiazole are scaffolds with potent antibacterial activity independently, and in this study, we synthesized coumarin-1,3,4-thiadiazole hybrid compounds and evaluated the in vitro antibacterial activity of the synthesized compounds. Methods: The two-step reaction, the Knoevangel condensation reaction followed by the nucleophilic addition reaction of Sciff bases, was conducted to synthesize nine pure compounds. The identity and purity of the compounds were characterized using FTIR and NMR spectroscopy. The in vitro antibacterial activity of the compounds was evaluated by determining their minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) against four different bacterial strains. Results: A total of nine clear, yellowish crystals were synthesized. The physical and spectroscopic characteristics confirmed the purity and identity of the compounds. All the compounds showed good in vitro antibacterial activity. A compound that has –OH on the coumarin moiety and –CH¬3 on the 1,3,4-thiadiazole moiety showed a comparative MIC and MBC value with the control group (ciprofloxacin). Conclusion: Hybridization of the two scaffolds, coumarins and 1,3,4-thiadiazoles, showed significant antibacterial activity, and 4F was the compound with promising antibacterial activity that needs further development and evaluation.
réclamations d’actionnaires pour pertes par ricochet en arbitrage investisseur-État sous les traités d’investissement canadiens
Authors: Vanhonnaeker Lukas
Published: April 2024

L’arbitrage investisseur-État, mode de résolution des différends aussi emblématique que controversé dans le domaine du droit international des investissements, soulève de nombreuses questions, dont celle relative à la possibilité reconnue aux actionnaires de présenter des réclamations pour pertes par ricochet. De telles réclamations permettent aux actionnaires qui répondent à la définition applicable d’investisseurs étrangers de demander en arbitrage investisseur-État une réparation pour un dommage qui prend la forme d’une réduction de la valeur de leurs actions. Une telle possibilité, bien qu’importante et cohérente au regard de l’objectif du droit international des investissements de protéger les investisseurs étrangers et leurs investissements, génère une série de risques qui, s’ils ne sont pas pris en compte, peuvent résulter en une atteinte aux droits des États, défendeurs dans les procédures d’arbitrage investisseur-État et, in fine, mettre à mal la légitimité de ce mécanisme de résolution des différends. Le modèle canadien d’Accord sur la promotion et la protection des investissements étrangers (APIE) de 2021 semble permettre de telles plaintes tout en tentant de les encadrer et de limiter les risques de procédures multiples ainsi que les dangers de double indemnisation et d’incohérence par le recours à deux mécanismes en particulier : celui des renonciations et celui de la jonction de plaintes.
Factores tecnológicos y personales asociados al logro educativo en estudiantes de México
Authors: Treviño Villarreal Diana Carolina , González Medina Mario Alberto
Published: April 2024

Sin lugar a dudas, existen factores que están asociados con el logro educativo del estudiantado. Al respecto, se han llegado a destacar aquellos que se ubican a nivel tecnológico y personal. Por tanto, el objetivo del presente trabajo fue determinar la asociación que existe entre los factores tecnológicos (Disponibilidad de bienes y uso de las TIC) y personales (Metas académicas y Autoeficacia) del alumnado de educación media superior con el Logro educativo. La muestra estuvo conformada por 7,299 jóvenes en México. Se utilizaron los resultados de la prueba PISA 2018 y el cuestionario para estudiantes; de la primera, se trabajó con los resultados en lectura, matemáticas y ciencias, los cuales, midieron el Logro educativo, mientras que, del segundo, se utilizaron un total de 14 preguntas que conformaron los cuatro factores en mención. Por consiguiente, se propuso un modelo teórico que se comprobó empíricamente aplicando modelaje de ecuaciones estructurales. Finalmente, se obtuvo una asociación directa y significativa tanto de la Disponibilidad de bienes como de las Metas con el Logro educativo, asimismo, de forma indirecta, Autoeficacia, Uso de las TIC y Disponibilidad de bienes se asociaron con el Logro. En conclusión, existen factores tecnológicos y personales que están asociados con el Logro educativo en estudiantes de educación media superior, de ahí el valor de seguir investigando bajo esta línea, asimismo, surge la importancia de considerar en futuros trabajos otros factores que tengan impacto en la educación de México.
Excursion into the history of relief imagery on geographic maps
Authors: Peresadko Vilina , Onishchenko Alina , Braslavska Oksana , Popov Vladyslav
Published: April 2024

The purpose of this article is to acquaint geographers with the history of transforming the ways depicting the relief on geographical maps in different countries of the world in order to optimize the choice of methods and techniques for working with old maps.

Basic material. An unequivocal, balanced and objective representation of the terrain is one of the main tasks of cartography. However, the representation of a three-dimensional element, which is a relief on a horizontal plane, is a problem that for centuries caused scientific controversy among geographers, cartographers, mathematicians and required new and new attempts to improve the image of this element on the maps. The article examines the retrospective of relief visualization development over the past thousand years. The authors highlight advantages and disadvantages of each of the applied methods of depicting the relief on geographical maps over the centuries. First of all, such as conditional-prospective and profile-silhouette ones. The article gives examples of these methods application in cartography. The study considers a place and role of Kharkiv scientists in the process of forming the doctrine of digital relief models.

Conclusions. Having analyzed the history and modernity in the field of relief visualization, it is possible to extrapolate its prospects for the future. Thus, the prospects may include improved resolution and detailing of input and output information, as well as the further development of techniques and methods for dynamic visualization of the terrain, which changes under the influence of adverse anthropogenic and natural (exo- and endogenous) processes and phenomena in real time
Methodological and methodical basis for the study of two-tiered anthropogenic landscapes
Authors: Koptieva Tetiana
Published: April 2024

The study of anthropogenic landscapes is an urgent topic in modern geography and ecology. Anthropogenic landscapes arise due to the anthropogenic activity impact on nature and have a two-tiered structure consisting of natural and anthropogenic components. The study of these landscapes requires a scientifically substantiated methodological and methodical basis that will allow us to collect, analyze and interpret data on the subject.

The purpose of the article is to consider the methodological and methodical aspects of the study of the two-tiered anthropogenic landscapes. It aims to define the theoretical foundations and practical approaches to the study of these landscapes, as well as to analyze the methods of data collection and processing that provide information about the natural and anthropogenic components of the landscape.

Main material. The article discusses the basic concepts and theoretical foundations of the study of two-tiered anthropogenic landscapes, including their classification and identification. The author considers methodological approaches to the study of anthropogenic landscapes, including the use of various methods of data collection and processing, analysis of cartographic material and the use of geographic information systems.

The scientific significance of this article lies in the fact that it provides new approaches to the study of the two-tiered nature of anthropogenic landscapes, which we can use in further scientific research and practical activities. The results of this study can be useful for geographers, ecologists and other specialists involved in the study and protection of nature.

Conclusions and further research: The study of the two-tiered nature of anthropogenic landscapes uses a variety of methods that help scientists better understand and assess the impact of anthropogenic activities on the natural environment. The use of geoinformation analysis, socio-geographical research, statistical analysis and other methods allows us to get a more complete picture of the two-tiered system, taking into account various aspects of the interaction between the anthroposphere and the biosphere. The study of the two-tiered nature of anthropogenic landscapes is an important part of modern geography and ecology. The use of classifications, integrated methodologies and geoinformation analyses helps to investigate the relationship between human activity and natural environment.
Еvaluation of the development strategy of the hotel and restaurant industry of Ukraine
Authors: Nikolaichuk Olha
Published: April 2024

In modern conditions, the development of the domestic hotel and restaurant industry is accompanied by significant problems caused by the COVID-19 pandemic and the full-scale war with the Russian Federation, which necessitates the search for promising directions of development and the development of plans for its recovery in the post-war period. The subject of research in the article is the development strategy of the hotel and restaurant industry of Ukraine. The purpose of the article is assessment of the strategy for the development of the hotel and restaurant industry of Ukraine and its infrastructure on this basis of the approach to the implementation of the strategy for the development of galusia in the minds of military renewal. Research methods: dialectical method, fundamental scientific methods: analysis, synthesis, taxonomic analysis, systematization, formalization (for analysis of the research object), abstract-logical method (for formulating concepts), graphical and tabular methods (for analysis of the results of the investigation). The following results were obtained: A model of taxonomic analysis of the development strategy of the hotel and restaurant industry is proposed. The taxonomic coefficients of the development strategy of the hotel and restaurant industry of Ukraine have been determined. Cyclicality in the development of the hotel and restaurant industry of Ukraine has been recorded. Especially negative changes in the industry were recorded in 2022 as a result of a full-scale. Conclusions: the conducted research made it possible to propose strategic directions for the development of the hotel and restaurant industry of Ukraine in the post-war period. The above-mentioned measures will make it possible to implement the necessary strategic changes in the hotel and restaurant industry, will contribute to the reconstruction of the national economy and the generation of additional financial flows, which will make it possible to strengthen the impact of industry restoration projects on the socio-economic development of the state.
CONOCIMIENTO PARA ENSEÑANZA ESTADÍSTICA EN EL LIBRO DE PRIMER AÑO DE EDUCACIÓN PRIMARIA EN PERÚ
Authors: Alencar Edvonete Souza de , Diaz-Levicoy Danilo
Published: April 2024

En este artículo describimos los resultados del análisis de las actividades propuestas para la enseñanza de la estadística de un libro de 1er de Educación Primara (6 y 7 años) en Perú, identificando cómo estas pueden influir en el conocimiento del profesor de Matemática en sus acciones docentes. Para lograr este objetivo se siguió una metodología documental, en la que analizamos el libro puesto a disposición por el Estado peruano. Presentamos las actividades que aparecen en el libro de texto de 1er año escolar, analizado desde el Modelo de Conocimiento Especializado del Profesor de Matemática – MTSK. Identificamos cómo las actividades propuestas pueden colaborar con el desarrollo del conocimiento en la enseñanza de las Matemática.
SABERES ARTICULADOS PARA ENSINAR MATEMÁTICA: PCN EM AÇÃO E TENDÊNCIAS DA EDUCAÇÃO MATEMÁTICA
Authors: Oliveira Quitéria Costa de Alcântara , Silva Janaína Costa e , Carvalho Maria Adriana Santos , Lopes Kênya Maria  Vieira
Published: April 2024

A constituição do saber profissional docente acontece na articulação entre elementos do objeto de ensino e das ferramentas para ensinar, que são mobilizados pelo professor ao longo da trajetória de formação, seja ela inicial ou continuada, nas mais diversas áreas do conhecimento. Este trabalho baseou-se nas discussões da disciplina “Fundamentos histórico-epistemológicos da Educação Matemática”, cursada no doutorado do Programa de Pós-Graduação em Educação em Ciências e Matemática da REAMEC. O estudo examina a proposta do PCN em Ação – Matemática em diálogo com as tendências da Educação Matemática, em vista às demandas de profissionalização do professor nas últimas décadas. Trata-se de uma pesquisa de natureza qualitativa, descritiva e exploratória, de cunho bibliográfico e documental, tendo por objetivo analisar as contribuições do PCN em Ação na profissionalização do professor para os anos iniciais. As sequências de atividades propostas pelo PCN em Ação contemplam encaminhamentos metodológicos e orientação didática aos professores, efetivamente sobre o saber-fazer docente. As discussões indicam que a profissionalização do professor deve acontecer permanentemente durante o processo de formação e de ensino. A respeito do saber profissional para ensinar matemática nos anos iniciais, os resultados apontam que o programa priorizou um ensino-aprendizagem contextualizado em situações-problema, visando tornar o aluno protagonista do processo e desmistificar a Matemática como verdade única e estática.
SALAS DE RECURSO MULTIFUNCIONAL TIPO 1: ANÁLISE DAS DISSERTAÇÕES SOBRE O ENSINO DE MATEMÁTICA
Authors: Nascimento Josiane Cotrin Pierasso do , Alves Denis Rogério Sanches , Speck Raquel Angela
Published: April 2024

No cenário brasileiro atual, observa-se a ampliação das discussões acerca do ensino de Matemática nas Salas de Recurso Multifuncionais Tipo 1 (SRM 1). O presente estudo teve como objetivo investigar o que tais pesquisas, materializadas na forma de dissertações, identificaram referente ao ensino da Matemática nesses espaços de inclusão educacional. Para tanto, realizou-se uma pesquisa bibliográfica na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) para selecionar pesquisas nos cursos de Mestrado no período de 2005 a 2021. Foram selecionadas 10 dissertações sendo que, da interpretação dos dados, emergiram três categorias de análise, denominados eixos: (E1) As percepções e concepções de licenciandos e professores (iniciantes e/ou em exercícios nas SRM 1) sobre o ensino da Matemática; (E2) Discussões, obser vações e teorizações a respeito das SRM 1 sobre o ensino da Matemática; (E3) Propostas e descrição de atividades como recurso pedagógico nas SRM 1 para o ensino da Matemática. Identificou-se que as pesquisas se concentram principalmente nos anos finais do Ensino Fundamental e que abordam conteúdos relacionados as operações básicas de adição, subtração e multiplicação. Nas conclusões se destacam a necessidade de variação nos métodos de ensino e o incentivo à formação e especialização docente.
GAMIFICAÇÃO NA EDUCAÇÃO DE JOVENS E ADULTOS (EJA): ENSINO DE QUÍMICA ATRAVÉS DE SEQUÊNCIA DIDÁTICA SOBRE NECROCHORUME
Authors: Lopes Carlos Alberto Pauleti , Becker-Ritt Arlete Beatriz , Azambuja Letícia Lopes
Published: April 2024

Os estudantes que frequentam a Educação de Jovens e Adultos (EJA) encontram obstáculos ao retornarem à sala de aula, seja pela dificuldade de conciliar a carga horária de trabalho com compromissos escolares, ou pelo desafio que representa a assimilação de novos conceitos após um período longo de afastamento do ambiente escolar. Diante dessas adversidades, é essencial repensar e adaptar práticas educacionais, para torná-las atrativas e desafiadoras. Nesse contexto, optou-se pela incorporação de elementos de gamificação, em sequências didáticas, para estimular o interesse dos estudantes, especialmente no conteúdo de química, e avaliar sua influência na predileção dos estudantes e que, consequentemente, pode contribuir para melhoria da aprendizagem. Assim, esta pesquisa foi realizada em uma escola pública na região mesometropolitana de Porto Alegre, no estado do Rio Grande do Sul, durante quatro encontros, que aconteceram entre maio e junho de 2022. Introduziu-se uma sequência didática focada no tema do necrochorume, abordado por meio de uma atividade gamificada, embasada na metodologia aprendizagem baseada em problemas. Os comentários espontâneos dos participantes, coletados durante as sessões, refletiram uma mudança positiva na percepção e no engajamento com o conteúdo. Essas descobertas sublinham a importância de revisitar e inovar as metodologias didáticas na EJA, demonstrando que atividades bem estruturadas, quando corretamente alinhadas aos objetivos pedagógicos, podem ser uma estratégia poderosa para superar os desafios enfrentados no ensino de química.
ОСОБЛИВОСТІ ОРГАНІЗАЦІЇ ДИСТАНЦІЙНОГО НАВЧАННЯ УКРАЇНСЬКОЇ МОВИ ЯК ІНОЗЕМНОЇ
Authors: Гейченко К. І. , Цупікова О. А.
Published: April 2024

Повномасштабна озброєна агресія спричинила значні зміни в системі освіти. У складних умовах воєнного стану перехід на дистанційне навчання дозволив відновити освітній процес і продовжити безпечно здобувати вищу освіту в Україні іноземним студентам незалежно від місця їх перебування. У статті маємо на меті дослідити особливості організації дистанційного навчання української мови як іноземної в умовах сьогодення. Розглянуто складнощі та відмінності викладання мови в дистанційному форматі порівняно з іншими дисциплінами гуманітарного профілю. Наголошено на важливості та необхідності комунікативної практики, яка є обов’язковою для отримання якісного результату. Проаналізовано позитивні аспекти (віддалений глобальний доступ, розмаїтість ресурсів і навчальних матеріалів тощо) і труднощі (технічні обмеження учасників, часовий пояс, ослаблення невербальної підтримки тощо) дистанційної освіти, які виникають під час викладання української мови як іноземної. Підкреслено, що онлайн-навчання підвищує вимоги до всіх учасників навчального процесу, активізує розвиток самостійної роботи у студентів і розширює компетенції викладача. Зазначено, що дистанційний формат може здійснюватися в синхронному й асинхронному режимах. Доведено, що найбільш ефективною формою дистанційного навчання під час вивчення української мови як іноземної є синхронне онлайн-заняття. Охарактеризовано його особливості в порівнянні із традиційним очним заняттям, виділено переваги та недоліки, окреслено вимоги до викладачів і студентів. Висвітлено особливості асинхронного формату навчання, можливості, які надає цей формат, і недоліки. Аналіз дистанційної форми навчання української мови як іноземної довів її продуктивність і перспективність. Нині онлайн-формат є гідною альтернативою традиційним заняттям в аудиторії, який забезпечує безперервний (а під час війни і безпечний) освітній процес.
AD-HOC-МЕТОД НАВЧАННЯ У ВЕББАЗОВАНОМУ ОСВІТНЬОМУ СЕРЕДОВИЩІ ЗАКЛАДУ ВИЩОЇ ОСВІТИ: ІНТЕГРАЦІЯ КОНЦЕПЦІЇ УПРАВЛІННЯ ЗНАННЯМИ
Authors: Романишин Ю. Л.
Published: April 2024

У статті схарактеризовано та визначено особливості ad-hoc-методу навчання в рамках веббазованого освітнього середовища закладу вищої освіти, обґрунтована доцільність активного застосування концепції управління знаннями в освітньому процесі. Акцентованого увагу на тому, що поступ глобалізованих інформаційних інтернет-сервісів, концепцій семантичної мережі, інструментів керування мережею знань сприяє стрімкому розвитку концепції веббазованого навчання, пропонує значні можливості для освітнього процесу. Роль викладачів-модераторів у процесі такого навчання полягає в тому, щоб освітнє середовище враховувало потреби студентів і забезпечувало їх ефективною навчальною підтримкою, стимулювало навчальний і професійний розвиток. Сучасні технології в освітньому процесі вищої школи уможливили поширення такої тенденції освіти, як навчання з будь-якого місця. Тому в рамках цієї тенденції досить ефективно реалізуються концепції гібридного й активного навчання, які поєднують педагогічні принципи гнучкості в освітньому процесі закладу вищої освіти та професійного «занурення». Непрості умови функціонування та розвитку українського освітнього простору сприяли швидкому перенесенню традиційного освітнього процесу у віртуальне середовище. Тому нині маємо гібридний освітній процес у закладі вищої освіти – поєднання дистанційного навчання (на основі концепції е-навчання) із традиційним освітнім процесом, який підкріплений веббазованими освітніми середовищами навчання з онлайн-освітніми платформами та сервісами. Охарактеризовано концепцію управління знаннями та виокремлено такі її ключові аспекти: технологічно-орієнтоване управління інформацією та знаннями, навчання в інтегрованому освітньому середовищі, комп’ютерно-підтримуване спільне навчання, ергономіка програмного забезпечення тощо. Ad-hoc-метод навчання варто розглядати як невід’ємну частину роботи зі знаннями. Оскільки таке навчання відбувається за допомогою сучасних інформаційно-комунікаційних і цифрових технологій, то з технічного погляду воно потребує конвергенції системи управління знаннями та системи веббазованого навчання. Метод аd-hoc-навчання реалізується в ad-hoc-середовищі, яке є інтегрованим предметним веббазованим освітнім середовищем для підтримки фахівців, залучених до виконання конкретного завдання. Установлено, що метод ad-hoc-навчання розширює та збагачує сферу навчальних активностей і діяльності, є більш гнучким методом навчання порівняно із традиційною, усталеною моделлю навчання у закладі вищої освіти.
ПЕДАГОГІКА МУЗИЧНОЇ ТЕРАПІЇ: ЗАКОРДОННИЙ ДОСВІД
Authors: Добровольська Р. О.
Published: April 2024

Стаття присвячена феномену музичної терапії як розвиненої галузі у Сполучених Штатах Америки та Європі. Установлено, що підготовка музичних терапевтів відрізняється в цих регіонах. Проаналізовано, що у Сполучених Штатах Америки музичні терапевти отримують ступінь бакалавра, магістра або доктора філософії в музичній терапії в університетах, які пропонують таку програму. Бакалаврська програма зазвичай триває чотири роки, магістерська – два роки, а докторська програма – чотири-п’ять років. Під час навчання студенти вивчають теоретичні та практичні аспекти музичної терапії, зокрема й основи психології, музичну теорію та техніки музичної терапії для різних популяційних груп, як-от діти з аутизмом, люди з деменцією тощо. Установлено, що в Європі, підготовка музичних терапевтів може відрізнятися залежно від країни, але загалом підготовка музичних терапевтів відбувається на магістерському рівні, який зазвичай триває два роки. Студенти вивчають теорію та практичні навички музичної терапії, а також здійснюють практичну роботу із клієнтами на різних етапах навчання. Навчання може здійснюватися в університетах або у фахових навчальних закладах, які спеціалізуються на музичній терапії. В обох регіонах підготовка музичних терапевтів охоплює багато практичних компонентів, як-от стажування та практикуми. Доведено, що навчальні програми музичної терапії в Європі забезпечують захопливий огляд обраних програм музичної терапії в десяти різних країнах, як-от: Австрія, Бельгія, Данія, Франція, Німеччина, Італія, Латвія, Велика Британія, Польща й Іспанія. У статті надається довідкова інформація про теми та філософії, що впливають на програми, критерії прийому, структуру навчального плану, клінічну підготовку, стажування, музичну підготовку та досвід, навчання й оцінку процедури щодо якості викладання та програми PhD. Узагальнено, що підготовка музичних терапевтів у Сполучених Штатах Америки та Європі має свої відмінності та спільні риси. У статті наведено загальний огляд основних рис підготовки музичних терапевтів у цих регіонах.
The exact dynamical equations of optimal nonlinear filtering: New approach and results
Authors: Surya Budhi , Surya Budhi Arta
Published: April 2024

This paper develops a novel method for solving nonlinear filtering problems in general continuous-time state-space models. The new method is developed based on an adaptation of the statistical estimation theory for incomplete information which has been primarily developed for maximum likelihood (ML) parameter estimation (Dempster). Distributional identities concerning the score function and information matrix of state are established. Using these identities and the duality principle between ML estimation and optimal control theory, a new set of fully explicit exact recursive filtering equations are derived. They consist of the governing dynamics of the state estimator, the covariance and information matrices. In particular, unless in linear observation, the dynamics of the covariance and information matrices take the form of Riccati equation under the influence of observation process in similar fashion to the dynamics of the state estimator. The results generalize the Kalman-Bucy filter, in particular (Benes,Daum,Kushner,Mortensen,Stratonovich) for nonlinear state-space. A discrete-time representation of the optimal filtering equation is provided for numerical computation. To compare the performance of the optimal filter, a sequential Monte Carlo method (particle filter) is proposed for the time discretization of the state-space. Numerical study confirms the consistency and the accuracy of the exact optimal filter compared to the particle filter's.
The second railway age: Redevelopment of heritage building & transformation of transport hub
Authors:   , Yao Shunyu
Published: April 2024

Wellington railway station was built in 1937, a symbol of the prosperity of rail transport, which declined over the next 85 years and was gradually replaced by road and air transport. Today, New Zealand's high urbanisation rate and reliance on private vehicles has led to problems such as traffic congestion and does not meet New Zealand's development targets for 2050 emissions standards. This research will be on the basis of a holistic architectural intervention for Wellington Station, including the renovation of the original heritage building and the redevelopment of its surrounding facilities and areas, while introducing contemporary New Zealand architectural concepts of sustainability and decolonisation to promote a better transport hub building. This will be done through a combination of both research through design and research about design research methods and based on extensive literature and precedent studies. The methodology and knowledge gained will be applied to the design of the redevelopment of the railway station, through a multimedia process of diagramming, sketching, iterative modelling and finally critically examining whether the building fulfils the originally specified objectives. As a result, the research will test whether the design of public transport hub typologies in architecture can positively influence characteristics such as the vitality, connectivity and walkability of cities and seeks to address the complex task of social, cultural, environmental, and climatic challenges
Research on Training Mode of Equipment Manufacturing Specialty in Vocational Colleges from the Perspective of “Three Education” Reform
Authors: Xing Rui , Chen Tuan , Xing Qi , Qi Baixue
Published: April 2024

With the continuous advancement of vocational education reform, comprehensively promoting the reform of the “three educations” based on the characteristics of professional teaching has become an urgent issue for equipment manufacturing specialties and teachers in vocational colleges in the new era. This paper delves deeply into the reform of the “three education” within the context of new changes and objectives in the training of equipment manufacturing professionals in vocational colleges. It proposes a series of reform paths for the existing personnel training mode, aimed at better adapting to the needs of equipment manufacturing professionals in the new era. These reforms aim to promote the qualitative development of vocational education, enhance the relevance and effectiveness of personnel training, and are intended solely for the reference of relevant stakeholders.