bluuebunny/crossref_metadata_2025 huggingface dataset:
JAK/STAT3 Pathway in Human Intestinal Epithelial Cells During Trefoil Factor 3(TFF3) Mediated Cell Migration
Authors: Zhuang Mengmeng , Le Juan , Zhu Bo , Zhang Wenwen , Yan Hao , Zhang Pan , Wang Ting , Sun Yong
Published: February 2020

Objective:

Trefoil factor family is expressed in several tissues of the body and provides gastric and intestinal protection and healing. This research aims to indicate the mechanism involved in its function.

Methods:

The intestinal epithelial cells were pretreated with JAK inhibitor AG490 or the concentration of 60ug/ml human recombinant trefoil factor, while the levels of phospho-STAT3, E-cadherin and N-cadherin were detected by Western Blotting. The levels of Matrix Metalloproteinases, Ecadherin and N-cadherin were evaluated by quantitative real time PCR. The cell migration was assessed by the transwell assay and the scratch assay. The immunofluorescence method was performed to detect the reduction of molecular E-cadherin.

Results:

hTFF3 activates the JAK/STAT3 pathway in HT-29 cells. The effect of JAK/STAT3 pathway mechanism on cell migration promoted by hTFF3. TFF3 promoting cell migration is associated with increased gene transcription of MMPs. hTFF3 alters E-cadherin expression. hTFF3 activates the expression of N-cadherin and down-regulates E-cadherin expression in HT-29 Cells.

Conclusion:

We have shown that TFF3 activated the JAK/STAT3 pathway. TFF3 increased the level of Matrix Metalloproteinases and N-cadherin, decreased that of E-cadherin, while AG490 had the opposite effect. TFF3 accelerated cell migration and the AG490 relieved the migrating rate to control the levels. TFF3 activated JAK/STAT3 pathway which was associated with intestinal epithelial cell migration.
Induction of Apoptosis by Nano-Synthesized Complexes of H2L and its Cu(II) Complex in Human Hepatocellular Carcinoma Cells
Authors: Diab Thoria , Mohamed Tarek M. , Hamed Alaa , Gaber Mohamed
Published: February 2020

Background:

Chemotherapy is currently the most utilized treatment for cancer. Therapeutic potential of metal complexes in cancer therapy has attracted a lot of interest. The mechanisms of action of most organometallic complexes are poorly understood.

Objective:

This study was designed to explore the mechanisms governing the anti-proliferative effect of the free ligand N1,N6-bis((2-hydroxynaphthalin-1-yl)methinyl)) adipohydrazone (H2L) and its complexes of Mn(II), Co(II), Ni(II) and Cu(II).

Methods:

Cells were exposed to H2L or its metal complexes where cell viability determined by MTT assay. Cell cycle was analysed by flow cytometry. In addition, qRT-PCR was used to monitor the expression of Bax and Bcl-2. Moreover, molecular docking was carried out to find the potentiality of Cu(II) complex as an inhibitor of Adenosine Deaminase (ADA). ADA, Superoxide Dismutase (SOD) and reduced Glutathione (GSH) levels were measured in the most affected cancer cell line.

Results:

The obtained results demonstrated that H2L and its Cu(II) complex exhibited a strong cytotoxic activity compared to other complexes against HepG2 cells (IC50 = 4.14±0.036μM/ml and 3.2±0.02μM/ml), respectively. Both H2L and its Cu(II) complex induced G2/M phase cell cycle arrest in HepG2 cells. Additionally, they induced apoptosis in HepG2 cells via upregulation of Bax and downregulation of Bcl-2. Interestingly, the activity of ADA was decreased by 2.8 fold in HepG2 cells treated with Cu(II) complex compared to untreated cells. An increase of SOD activity and GSH level in HepG2 cells compared to control was observed.

Conclusion:

The obtained results demonstrated that H2L and its Cu(II) complex exhibited a strong cytotoxic activity compared to other complexes against HepG2 cells (IC50=4.14±0.036μM/ml and 3.2±0.02μM/ml), respectively. Both H2L and its Cu(II) complex induced G2/M phase cell cycle arrest in HepG2 cells. Additionally, they induced apoptosis in HepG2 cells via upregulation of Bax and downregulation of Bcl-2. Interestingly, the activity of ADA was decreased by 2.8 fold in HepG2 cells treated with Cu(II) complex compared to untreated cells. An increase of SOD activity and GSH level in HepG2 cells compared to control was observed.
Implementasi nilai-nilai multikultural dalam pembelajaran PKn
Authors: Mazid Sukron , Suharno Suharno
Published: February 2020

Penelitian ini bertujuan untuk mengungkapkan 1.) Bagaimana implementasi; 2.) Faktor pendukung; 3.) Hambatan dalam implementasi nilai-nilai multikultural dalam pembelajaran PKn di MA Ali Maksum Krapyak Yogyakarta. Pendekatan penelitian menggunakan kualitatif. Penentuan subjek dengan purposive. Teknik pengumpulan data observasi, dokumentasi, wawancara. Keabsahan data diperoleh dengan teknik trianggulasi sumber. Teknik analisis dengan reduksi data, sajian data, dan penarikan simpulan. Hasil penelitian menunjukan bahwa implementasi dilakukan dengan dua tataran: a.) Konseptual melalui visi, misi, tujuan, sedangkan b.) Operasional melalui pertama perencanaan pembelajaran, kedua pelaksanaan pembelajaran melalui: 1.) Menanamkan nilai untuk bersikap toleransi, menghargai, demokrasi, keadilan, kese-taraan dan menghormati keragaman; 2.) Metode yang demokratis, kooperatif dan bervariasi; 3.) Materi yang diajarkan mengandung wawasan keragaman, persitiwa dan masalah sosial; 4.) Melatih peserta didik untuk memecahkan masalah-masalah sosial; dan 5.) Media pembelajaran dengan media yang bervariasi. Ketiga evaluasi pembelajaran. Faktor-fakor pendukung adalah peran kepala sekolah, peran guru, kurikulum sekolah, media pembelajaran, kegiatan dan program sekolah, iklim sekolah, dan peserta didik. Hambatan yaitu kurangnya kesiapan dan kesadaran peserta didik, kurangnya sarana dan prasarana, dan minimnya ruang untuk melakukan refleksi. AbstractThis research aims to reveal 1.) How the implementation; 2.) Factor supporting; 3.) Obstacles for the implementation of values multicultural in teaching Pkn in MA Ali Maksum Krapyak Yogyakarta. Approach the research uses qualitative. The determination of the subject with the purposive. Technique data collection observation, documentation, interview. The validity of data is collected to technique trianggulasi source. Technique analysis by reduction data, cereal offering data, and the withdrawal of drawing conclusions. The results of the study showed that the implementation of be done with two landscape a.) conceptual through vision, mission, the purpose and b.) operational through first planning learning. Second presentation weighting through; 1.) Imparting value to be tolerance, appreciate, democracy, justice, equality and respecting diversity; 2.) The method of democratic, cooperative and vary; 3.) The materials given containing insight diversity, 3 and a social issue; 4.) Train school tuition to tackle problems social; and 5.) The media teaching to the media varying. Third evaluation teaching. Supporting factor-factor is the role of the head school, the teacher, school curriculum, media teaching, activities and school program, climate school, and school tuition. Obstacles that is lack of readiness and awareness school tuition, lack of facilities and infrastructure, and inadequate room to make reflection.
Hugh Jackman vs. Skin Cancer Awareness Month: Promoting Public Interest in Basal Cell Carcinoma (Preprint)
Authors: Torgerson Trevor , Austin Jennifer , Khojasteh Jam , Vassar Matt
Published: February 2020

BACKGROUND

Public awareness for BCC is particularly important, as its major risk factors — increased sun exposure and number of sunburns — are largely preventable.

OBJECTIVE

Determine whether social media posts from celebrities has an affect on public awareness of basal cell carcinoma.

METHODS

We used Google Trends to investigate whether public awareness for basal cell carcinoma (BCC) increased following social media posts from Hugh Jackman. To forecast the expected search interest for BCC, melanoma and sunscreen in the event that each celebrity had not posted on social media, we used the autoregressive integrated moving average (ARIMA) algorithm.

RESULTS

We found that social media posts from Hugh Jackman, a well-known actor, increased relative search interest above the expected search interest calculated using an ARIMA forecasting model.

CONCLUSIONS

Our results also suggest that increasing awareness by Skin Cancer Awareness Month may be less effective for BCC, but a celebrity spokesperson has the potential to increase awareness. BCC is largely preventable, so increasing awareness could lead to a decrease in incidence.
Design of an mHealth app to promote day-long physical activity in older adults with chronic pain: Phase 1 of the MORPH study (Preprint)
Authors: Fanning Jason , Brooks Amber , Ip Edward , Nicklas Barbara , Rejeski W. Jack
Published: February 2020

BACKGROUND

Participating in physical activity and minimizing time spent sitting is an effective strategy for managing pain in older adults. Theory-based mHealth tools are integral to effective day-long physical activity interventions, but it is vital that mHealth tools undergo an iterative development process alongside members of the target population to ensure their uptake and use.

OBJECTIVE

We subjected a preliminary social cognitive smartphone application (Companion App) designed to promote day-long movement to a user centered design process with the assistance of low-active older adults with chronic multisite pain. The Companion App integrates ecological momentary assessments of pain, Fitbit activity monitor data, and smart weight scale data to provide real-time feedback on the relationships between movement, sitting, and pain and to facilitate goal setting and achievement.

METHODS

We recruited participants (N=5; 71.8 5.54 years old) sequentially to participate in a three-phase iterative design study. First, each participant received a brief orientation to physical activity, was exposed to the application, and engaged in a Think Aloud protocol. Use and usability issues were noted by study staff. The participant then used the app for one week in their daily lives, and then returned to provide feedback. Issues were identified from participant feedback, discussed with the study team, and modified before the next participant began the study.

RESULTS

Participant interviews yielded feedback in areas related to technology selection and operation, app design/form, and intervention clarity. Regarding technology, the use of the Fitbit activity monitor revealed no issues, but there were barriers to the use of the Fitbit Aria 2 scale, including incompatibility with a widely used home internet router. Switching to a cellular enabled scale alleviated this issue. With regard to form, modifications were made to several key interface elements in response to participant feedback to aid in clarity. Finally, initial participant experiences revealed the need to separate the intervention orientation from the technology orientation to minimize informational load.

CONCLUSIONS

Our brief user-centered design process produced key changes in our intervention orientation, the form and function of the Companion App, and the technologies that support the app. These are vital elements that are likely to hamper the perceived usefulness and utility of the Companion App in the context of a large trial and eventual public use. We recommend the conduct of such a process any time mHealth is used in research or medicine to account for changing populations and preferences. Moreover, publication of lessons learned can help to establish a foundation of knowledge for designing apps for underserved populations such as older adults.

CLINICALTRIAL

ClinicalTrials.gov Identifier: NCT03377634
Gasless Trans-Umbilical Laparoscopically-Assisted Appendectomy in the Pediatric Population: An Early Experience
Authors: Al-Taher, Md. Raed Nael , Ibrahim Khrais, M.D. Ibrahim Abdel Qader , Al-Tawarah M.D. Tayseer Ahmad Sabbah , Al-Sebou’ M.D. Mohammad Talat M. , Alnatsheh M.D. Walid Adel Zakaria , Alqudah M.D. Yahia Zakaria , Alma’aitah M.D. Suhib Waleed
Published: February 2020

Background: The aim of this study is to determine the feasibility and safety of the single-port gasless trans-umbilical laparoscopically-assisted appendectomy in the pediatric age group at a single center in a tertiary university hospital in Jordan. Methods: Between April 2018 and July 2019, the surgical records of all patients aged between 0 and 13 years treated with trans-umbilical laparoscopic-assisted appendectomy TULAA for a suspected appendicitis following a clinical, laboratory and ultrasound findings were reviewed retrospectively. Baseline characteristics, white blood cell count, operative time, intraoperative findings, need for additional trocars or for conversion, length of hospital stay and surgical complications were reported.Results: 36 cases were included in the study, 23 (64%) were completed successfully using the gasless TULAA technique. Gas insufflation was needed in 10 (28%) cases and only 3 (8%) had to be converted to the three-port laparoscopic appendectomy technique. There was no significant difference between the gaseous and gasless groups in terms of baseline characteristics, BMI, surgery duration, postoperative recovery period or length of stay. However, the group of patients who needed gas insufflation to complete the procedure had a higher white blood cell count compared to the gasless group. The surgery was completed successfully by senior general surgery residents in 27 (75%) cases while the consultant’s intervention was needed in the remaining cases. The gasless TULAA group were less likely to require complex analgesia (i.e., IV analgesia) compared to the gasless group (OR=0.683).Conclusions: Gasless TULAA is a feasible procedure that can be performed safely by surgical residents as an initial approach for all grades of acute appendicitis in the pediatric age group.
DOSE-DEPENDENT CHRONIC TOXICITY SCREENING OF HINOKITIOL IN ZEBRAFISHES: BEHAVIORAL AND HISTOLOGICAL APPROACH
Authors: KRISHNAPRIYA MADHU VARIER  , SUMATHI THANGARAJAN
Published: February 2020

Objectives: Parkinson’s disease (PD) is categorized as a movement disorder symptomized by weakening the motor skills of the patients. The root cause of the disease is the neurodegenerative dopaminergic loss in the substantia nigra of the patient’s brain. This havoc disease majorly affects the people above the age of 60 years. Moreover, PD incidences strike almost 70% of the neurological disorders of the aged population worldwide. There are no perfect curative drugs in the medical world for the disease. Since the past few decades, several plant secondary compounds were in preclinical trials to treat this disease. Hinokitiol (HIN), a monoterpenoid from the heartwood of cupressaceous plants, is widely used in hair tonics, toothpaste, cosmetics, and food as an antimicrobial agent. It is well reported as an anti-stroke agent as well.

Methods: In the present study, the dose-dependent (5, 10, 15, 20, and 25 mg/kg) chronic toxicity of HIN was studied for 28 days using zebrafishes. The toxicity was analyzed in vital organs such as brain, liver, kidney, spleen, heart, and blood count followed by behavioral toxicity to target the drug against parkinsonism.

Results: The study revealed that the higher doses of 20 and 25 mg/kg HIN treatment were toxic to the fish brain, spleen, as well as cardiomyocytes. It showed a variation in blood count as well at 10 mg/kg dose itself.

Conclusion: Hence, the study revealed the protective efficacy of the HIN at its therapeutic dosage of 5 mg/kg as a neuroprotective drug, with minimal vital organ toxicities.
IN VITRO EVALUATION OF ANTIOXIDANT POTENTIAL AND TOTAL PHENOLIC CONTENT OF BARLERIA LONGIFLORA LEAF EXTRACTS
Authors: JOTHIMUNIYANDI M  , JAYACHITRA A
Published: February 2020

Objective: The aim of this present study is to estimate the antioxidant potential found in the leaves of Barleria longiflora that belongs to the family Acanthacea.

Methods: Antioxidant activity of six different solvent extracts system of B. longiflora leaves was assayed for 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical activity, scavenging of hydrogen peroxide (H2O2), ferric reducing antioxidant activity, metal chelating ability assay, and total reducing ability. Total phenolic content of the extracts was determined by Folin–Ciocalteu method.

Results: The radical scavenging activity was evaluated by DPPH of ethanol extract at concentration of 100 μg/mg was found to be 56.5% followed by methanol 48.4%, whereas maximum scavenging of H2O2 was observed in ethanol 83.4% followed by chloroform 70.8%. Ethanolic extract of B. longiflora leaves showed the highest value in ferric reducing antioxidant power assay 74.8%, metal chelating activity 61.6%, and total reducing ability 0.76±0.02 when compared to the standard ascorbic acid.

Conclusion: The results suggest that the antioxidant potential of the ethanol extract has the highest activity in compared to other five extracts of B. longiflora leaves.
EFFECT OF EPIPHYTES EXTRACT ON THE PEROXIDASE ACTIVITY IN THE CROP SEEDLINGS CHALLENGED WITH FUNGAL PATHOGENS
Authors: HAMZAH JUMAH ESSA BARKAH  , LOKESH S
Published: February 2020

Objectives: The objective of the present study to test the angiospermic epiphytes such as Bulbophyllum propinquum and Dendrophthoe falcata for their effect against some pathogenic fungi of sorghum, paddy and chilli, through seed treatment and foliar spray in challenging with the infectivity of the pathogens.

Methods: The plant extracts were carried out by the Soxhlet extraction method and culture of pathogenic fungi were cultured and maintained in vitro for further use. The peroxidase (POX) enzyme activity in the seedlings was measured spectrophotometrically at 300 nm and expressed as Δ optical density 300 nm/min/mg protein.

Results: The results of this study indicated 92 and 98% seed germination in the control samples, respectively. In the chilli and paddy which were reduced to 64 and 58% in seedlings inoculated with Colletotrichum dematium, Drechslera oryzae, correspondingly. Similar observation was made in sorghum samples on treatment with Fusarium solani and Fusarium oxysporum, whose germination was drastically reduced to 74 and 69% compared to control (92%). In all the cases, seed treated with epiphytes extracts indicated the stimulated germination over pathogen inoculated samples. In parallel to this, the peroxidase assay also indicated its diminished/reduced activity in pathogen treated seedlings of the selected crop species. Seedlings of epiphytes extract treatment challenged with respective pathogens showed an increased activity over only pathogen treated samples.

Conclusion: The results clearly indicated the influence of POX in early growing stages of the seedlings corresponds to 12–72 h of incubation in spite of pathogenic activity. Thus, it proved the loss of enzyme activity seedlings on pathogen infection. Contrastingly, POX activity in the seedlings irrespective of the crop species remained high during the early growth stages of the seedlings.
POTENTIAL ANALGESIC AND ANTI-INFLAMMATORY EFFECT OF CUMINUM CYMINUM AND BORAGO OFFICINALIS IN RATS AND MICE
Authors: GIHAN F ASAAD  , ALAA Q REDAI  , ALAA O HAKAMI  , FATIMAH Y GHAZWANI  , YOUSRA NOMIER  , SAEED ALSHAHRANI
Published: February 2020

Objective: Our research aimed to study the potential therapeutic effect of Cuminum cyminum and Borago officinalis seed oil against inflammation induced by carrageenan as well as its central and peripheral analgesic effect.

Methods: The anti-inflammatory effect was determined by measuring the edema rate and inhibition rate using Plethysmometer. Writhing test and hot plate test were used to determine the peripheral and central analgesic effect, respectively.

Key Findings: Significant anti-inflammatory effects were witnessed for all the drugs at different dose levels in the results. Substantial analgesic effect against both peripheral and central pain induction was also incurred on administration of all doses of C. cyminum and B. officinalis seed oil.

Conclusion: The C. cyminum and B. officinalis seed oil has potent anti-inflammatory and analgesic effects.
EVALUATION OF ANTIOXIDANT POTENTIAL AND QUANTITATIVE ESTIMATION OF PHENOLIC AND FLAVONOID CONTENT IN SOME SELECTED NEPALESE MEDICINAL PLANTS
Authors: KHAREL RUPAK , RAJ SHARMA KHAGA
Published: February 2020

Objective: The aim of this study is to evaluate the antioxidant potential, determination of total phenolic and flavonoid content in nine selected medicinal plants Spondias pinnata, Melia azedarach, Ageratina adenophora, Urtica dioica, Curcuma longa, Bauhinia variegata, Elaeocarpus angustifolius Blume, Achyranthes aspera, and Psidium guajava from Kavre district of Nepal using in vitro studies.

Methods: Methanolic plant extracts were prepared by cold percolation method. The methanol extract of nine medicinal plants collected from Kavre district of Nepal, was screened for assessing bioactive phytoconstituents followed by antioxidant property, total phenolic, and flavonoid content. Different plants collected were powdered and extracted with methanol, concentrated by a rotatory evaporator and analyzed for the presence of phytochemicals. The antioxidant potential of the plant extracts was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay.

Results: The phytochemical analysis of methanolic extracts of all nine medicinal plants displayed the presence of various secondary metabolites such as alkaloids, flavonoids, polyphenols, saponins, and quinones. The extract of S. pinnata showed the highest percentage of radical scavenging activity up to 87.94±1.88 with 50% inhibitory concentration (IC50) 17.51±1.27 μg/mL, followed by B. variegata, 80.63±1.06 with IC50 value 26.55±2.61 μg/mL. The standard, ascorbic acid has IC50 value of 20.13±1.17 μg/mL. Further, the ethyl acetate fraction of S. pinnata showed the maximum percentage of radical scavenging (85.92±1.37) with IC50 value of 46.95±1.17 μg/mL. Moreover, S. pinnata displayed the highest total phenolic content (TPC) 48.26±1.23 mg GAE/g (milligram gallic acid equivalent per gram) extract while the highest flavonoid content was displayed by Melia azedarach 41.07±1.53 mg QE/g (milligram quercetin equivalent per gram) extract measured by the Folin–Ciocalteu reagent method and aluminum chloride colorimetric method.

Conclusions: The preliminary results of this study have put forward the extract of S. pinnata showed the highest percentage of radical scavenging activity and S. pinnata displayed the highest TPC while the highest flavonoid content was displayed by Melia azedarach methanolic extracts although the further studies are needed to assess its mechanism of action.
EFFECT OF SALACIA OBLONGA ROOT EXTRACT AGAINST CLINICAL ISOLATES STAPHYLOCOCCUS AUREUS
Authors: ANANTHULA MOUNIKA  , BHARGAVI POKALA  , MD. ZAHOORULLAH S , ANJANEYULU MUSINI
Published: February 2020

Objective: Salacia oblonga Wall. is an important medicinal plant belonging to the family Celastraceae. The study reports the effect of S. oblonga root extracts against clinical isolate Staphylococcus aureus

Methods: Antibacterial activity was evaluated by agar diffusion method and assay for minimum inhibitory concentration (MIC) of extract. Further, the effect of S. oblonga extract determined by DNA fragmentation and respiratory dehydrogenase enzyme activity assays.

Results: S. oblonga ethyl acetate root extract was evaluated for antibacterial activity towards clinical isolate S. aureus. Bacterial growth was determined in treated and control cells. Extract displayed good growth inhibition and MIC of the extract was 80 μg/ml. DNA fragmentation assay was carried out, this result has shown that treated bacterial cell has DNA damage compared to the control cell. Further, respiratory dehydrogenase enzyme activity was determined. In the treated cells, enzyme activity was low compared to the control cells.

Conclusion: Salacia oblonga root extract inhibiting the growth of S. aureus by different modes of action.
Towards Trusted Identities for Swiss Researchers and their Data
Authors: Raemy Julien A. , Schneider RenÃ© Martin
Published: February 2020

In this paper we report on efforts to enhance the Swiss persistent identifier (PID) ecosystem. We will firstly describe the current situation and the need for improvement in order to describe in full detail the steps undertaken to create a Swiss-wide model. A case study was undertaken by using several data sets from the domains of art and design in the context of the ICOPAD project. We will provide a set of recommendations to enable a PID service that could mint Archival Resource Key (ARK) identifiers or a flavour of Research Resource Identifiers (RRIDs) as complement to Digital Object Identifiers (DOIs). We will conclude with some remarks concerning the transferability of this approach to other areas and the requirements for a national hub for PID management in Switzerland.
Bordando por la paz y la memoria en México: feminidad sin sumisión y aspiraciones democráticas
Authors: Olalde Rico Katia
Published: February 2020

: En el presente artículo comparo la labor de los colectivos Fuentes Rojas y Bordamos por la Paz Guadalajara para proponer que, en el contexto de la “guerra contra el narcotráfico en México”, el bordado a mano resultó una actividad idónea para rescatar la memoria de las víctimas de la violencia debido a su capacidad para activar el cuerpo, suscitar sensaciones, despertar emociones e inquietar la mente racional de los participantes. Con base en este análisis, sugiero que la Iniciativa Bordando por la Paz y la Memoria buscó que el bordado evocara una feminidad representada como fuente de calidez, solidaridad y apertura, y no sumisa, resignada o privativa de las mujeres. Finalmente, propongo que los atributos que justificaron la exclusión del bordado a mano de las Bellas Artes resultaron óptimos para poner en práctica esquemas de colaboración inspirados en los principios democráticos de “libertad e igualdad para todos”.
Giro material en la crítica feminista de Julieta Kirkwood
Authors: Moraga Cavour Odaimis Nicole
Published: February 2020

El presente artículo pretende leer el trabajo de Julieta Kirkwood desde la posición crítica que desarrolla respecto a la materialidad de los discursos identitarios del proyecto nacional popular de la izquierda en Chile, de los saberes y soportes disciplinarios, así como de la posibilidad del pensamiento y política feministas. Entendiendo la materialidad, de acuerdo con Judith Butler, como un efecto del poder que se estabiliza a través del tiempo, se analizarán las operaciones y estrategias que despliega Julieta Kirkwood para desnaturalizar las atribuciones esencialistas sobre las mujeres que sostienen las políticas de interpretación y representación en el campo de la política y el conocimiento en la década de 1980. Estas operaciones desnaturalizadoras serán entendidas como una perspectiva material determinante en el pensamiento de Julieta Kirkwood.
Feminismo, reconocimiento y tolerancia
Authors: Rivera Osorio Axel
Published: February 2020

Este artículo busca mostrar la diferencia entre los paradigmas que han guiado al feminismo, pasando de la búsqueda por la igualdad hacia una búsqueda de la libertad. El feminismo ayudó a crear mayores grados de reconocimiento y tolerancia al generar nuevas articulaciones simbólicas a lo largo del siglo xx y en lo que va del xxi. No se trata de un camino unívoco. Los feminismos se han movido en diferentes paradigmas para ser capaces de incrementar los ámbitos de reconocimiento social; aquí se intenta vislumbrar algunos pasos para que esto fuera posible, en un contexto donde lo político se juega entre la dislocación y la configuración de nuevas identidades políticas, así como en la reconfiguración de la esfera pública.
La eficiencia de los múltiplos de capital: caso México
Authors: Téllez Pérez Julio
Published: February 2020

Los múltiplos de capital son razones financieras ampliamente utilizadas por los analistas financieros con el propósito de tomar decisiones de inversión en acciones (P) de las empresas que cotizan en los mercados bursátiles. Los dos principales indicadores son el precio de la acción a utilidad neta (PU) y el valor mercado a valor en libros (P/VL). Ambos múltiplos tienen como factor común la perspectiva del mercado con respecto al valor en libros de la utilidad neta y el capital contable. Se tomó una muestra de 30 empresas que cotizaron en la bolsa mexicana de valores entre 2008 y 2016 (9 años), estableciendo tres periodos de análisis de 3 años cada uno en función a la volatilidad de la economía mexicana medido a través del índice global de la actividad económica (Igae). El primero se le denomino crisis (1), el segundo recuperación (2) y el tercero expansión (3). Para encontrar la posible asociación de P/U y P/VL con P, se utilizó el método generalizado de los momentos (GMM) para las estimaciones, encontrando que P/VL presentan la mayor relación con P en los 3 periodos económicos mientras que P/U solo presento relación significativa en el periodo (2) y (3) concluyendo que este medidor es muy sensible a los cambios económicos mientras que P/VL es robusto y no pierde significancia ante la volatilidad económica.
Impacto de los estándares internacionales de información financiera en la calidad contable: evidencia desde Latinoamérica y el Caribe
Authors: Cardona Montoya Juan Camilo , Cano Morales Abel María , Gómez Sánchez Andrés Felipe
Published: February 2020

Este artículo examina el impacto de la aplicación de los Estándares Internacionales de Información Financiera (IFRS) en la calidad contable (calidad del reporte financiero) de las economías latinoamericanas y del Caribe, respecto a su marco normativo local (Local GAAP); usando una muestra de compañías cotizadas en Latinoamérica y el Caribe durante los periodos 2006-2016, se valora la calidad contable bajo tres criterios de medición: la manipulación del resultado, el reconocimiento oportuno de pérdidas (atributos contables) y la relevancia valorativa (atributos de mercado). Los hallazgos sugieren un mejoramiento parcial de la calidad contable, evidenciado a través de una disminución en el nivel de manipulación del resultado sólo después de varios años de aplicación de IFRS. Sin embargo, no se evidencia mayor oportunidad al reconocer grandes pérdidas, al tiempo que, la información contable generada bajo los estándares IFRS, no es valorada con mayor utilidad por los agentes de mercado.
Modelo propuesto para la identificación y predicción de bancos en dificultades, según el contexto del Comité de Supervisión Bancaria de Basilea
Authors: Gutiérrez Ramírez Dulce María , Gaggero Sager Luis Manuel , Marín Hernández Salvador , Muñoz Black Celso Joaquín
Published: February 2020

Este trabajo propone, y describe, una investigación empírica cuyo objetivo es determinar un modelo para la identificación (la cual forma parte de las orientaciones del BCBS de 2002 y de 2015(1)) y la predicción de bancos en dificultades, ya que la detección de una de ellas es una de las propiedades deseables de cualquier sistema de alarma (Labatut, et. al., 2009). El modelo se basa en la aplicación del análisis discriminante a nueve bancos mexicanos en 1999, año que fue clave para la estabilidad y certidumbre del sistema financiero mexicano con la publicación de la LPAB(2) y la creación del IPAB(3). Los indicadores financieros considerados han sido utilizados por Beaver, Altman y Ayala, y el contexto de estos indicadores está incluido actualmente dentro de los marcos de Basilea II y III(4). Con la función discriminante obtenida del modelo propuesto y con base en el estudio del caso, el modelo se probó con nueve bancos mexicanos, que estuvieron en la crisis bancaria mexicana, lo cual dio un resultado del 100% en la identificación de su respectiva situación financiera. Además, se predijo esta situación para cuatro bancos mexicanos en el periodo 2000-2008 y un banco de los Estados Unidos, afectado por la crisis sub-prime, para el periodo 2000‑2010; la predicción basada en los resultados empíricos concuerda, en general, con los informes anuales del IPAB y con las opiniones de los presidentes del banco estadounidense. Se concluye que el modelo propuesto puede utilizarse, adicionalmente a los modelos de alerta temprana institucionales, para predecir si un banco está o no en dificultades considerando, además de los recursos propios, la provisión para pérdidas crediticias. Es necesario señalar que, dada la complejidad matemática del análisis discriminante y a las hipótesis involucradas, se implementaron técnicas estadísticas y algoritmos para su desarrollo.
TRATAMENTO CIRÚRGICO DE CANINO INCLUSO EM REGIÃO MENTUAL: RELATO DE CASO
Authors: Figueiredo de Brito Resende Rodrigo
Published: February 2020

RESUMOO dente denominado incluso nada mais é que um dente retido ou impactado dentro do alvéolo dentário de maneira parcial ou completa que não conseguiu erupcionar por motivos patológicos ou simplesmente anatômicos após o período de rizogênese. O canino, em especial, é de suma importância sob os pontos de vista estético e funcional. O deslocamento do canino incluso ultrapassando, ou se aproximando da linha média antes da erupção dentária do mesmo, é mais frequente na mandíbula do que na maxila.  Este trabalho tem por objetivo descrever o caso de um paciente de 21 anos que apresentava um canino incluso na região mentual, em posição transversal, inicialmente visualizado em uma radiografia periapical e posteriormente submetido a radiografia com a técnica de Donavan. Através de uma radiografia oclusal, foi possível observar o posicionamento do dente para a vestibular mentoniana e íntima relação do dente retido com as raízes dos incisivos centrais decíduos do paciente. Foi realizada a extração do dente retido no mento, removendo o mesmo por completo sendo feitas osteotomias e odontossecções. O paciente está em acompanhamento clínico à 1 ano após o tratamento cirúrgico.Palavras – chave: Dente incluso; Cirurgia Oral; Imaginologia. ABSTRACTThe tooth inserted  is nothing more than a tooth retained or impacted within the dental socket partially or completely that failed to erupt for pathological or simply anatomical reasons after the period of rhizogenesis. The canine, in particular, is of the utmost importance from the aesthetic and functional points of view. The displacement of the canine, even surpassing or approaching the midline before tooth eruption, is more frequent in the mandible than in the maxilla. This work aims to describe the case of a 21 - year - old patient who had a canine included in the mental region, in a transverse position, which was initially visualized on a periapical radiograph and later submitted to radiography with the Donavan technique. An occlusal radiograph showed the positioning of the tooth for the mental vestibular and the intima relationship of the retained tooth with the roots of the patient's central deciduous incisors. Removal of the tooth retained in the denture was performed, removing the tooth completely and osteotomies and odontosections were performed. The patient is in clinical follow-up at 1 year after the surgical treatment. key words: Tooth included; Oral surgery; Imaginology.
Efektivitas Atraktan terhadap Daya Tetas dan Jumlah Telur Nyamuk Aedes albopictus di Laboratorium
Authors: Ridha Muhammad Rasyid , Fadilly Abdullah , Hairani Budi , Sembiring Wulan RSG , Meliyanie Gusti
Published: February 2020

Abstract. Aedes albopictus can act as a primary or secondary vector of dengue hemorrhagic fever andchikungunya. Its population needs to be controlled. One of the environmentally-friendly control methods isthe use of ovitrap. Ovitrap will be more optimal if it added by attractant substances from easily obtainedingredients in the surrounding environment. This study aims to determine the effectiveness of attractants inthe form of water-soaked paddy (Oryza sativa), cogongrass (Imperata cylindrica) and Indian goosegrass(Eleusine indica). An experimental study with a completely randomized design (CRD) was carried out at theEntomology Laboratory of Balai Litbangkes Tanah Bumbu in January - April 2018. The population of thisstudy is the 10th filial of Ae. albopictus laboratory colonization and gravid female mosquito as samples.Material combination in the study was paddy straw soaking water (ARJP), Indian goosegrass immersionwater, cogongrass soaking water, Ae albopictus used eggs laying water (ABT), and distilled water as control(K). Repetition was done five times. Effectiveness of attractants analyzed by ANOVA and LSD tests. Datanormality tested by Kolmogorov-Smirnov test, if it was not fulfilled, the Kruskal Wallis test was used. Theresults showed that the use of attractants of water-soaked paddy, Indian goosegrass and cogongrass provedto have a different effect on the number of Aedes albopictus mosquito eggs compared to aquades and eggslaying water, but there was no influence between the three types of attractants.
Penemuan Mikrofilaria Brugia malayi di Wilayah yang Telah Lulus Transmission Assesment Survey (TAS-3) di Kabupaten Kotawaringin Barat Provinsi Kalimantan Tengah
Authors: Rahayu Nita , Suryatinah Yuniarti , Paisal Paisal
Published: February 2020

Abstract Kotawaringin Barat is a filariasis endemic area and has been undergoing mass drugs adminstration (MDA) for 5 years. The district passed third phase of Transmission Assesment Survey (TAS-3) in 2016. In the TAS-3, we found 4 children with filariasis antibodies. In this study, we performed microscopic examination of microfilaria to confirm the results of TAS-3, as well as the measurement of knowledge, attitudes, and behavior towards the treatment of filariasis. The study was conducted in Dawak Village and Sungai Bakau Village, with a total sample of 620 respondents. The results of microscopic examination are 5 respondents with Brugia malayi in their blood, consisting of 4 respondents in Dawak Village and 1 respondent in Sungai Bakau Village. The percentage of respondents who know the causes and symptoms of filariasis is very small. Although most respondents have a positive attitude towards treatment, the right treatment behavior is still very low. One respondent was found to be reinfected with B. malayi. In addition, it is suspected that there is transmission from animals to humans, but it still needs further investigation.
Mapas de Trocas Intelectuais: representações para cooperação na educação a distância
Authors: Corbellini Silvana , Luiza Rheingantz Becker Maria
Published: February 2020

Este artigo apresenta uma pesquisa sobre a cooperação em um curso de especialização a distância em uma universidade federal. O objetivo da pesquisa foi investigar e analisar como os processos individuais e interindividuais possibilitam a ocorrência da cooperação intelectual entre os discentes. Elegeu-se a teoria de Jean Piaget para a fundamentação, a fim de auxiliar na compreensão do método de cooperação. Para responder ao problema da pesquisa registraram-se as sequências de interações entre os participantes do curso, traçando-se rotas e desenhando-se Mapas das Trocas Intelectuais. Estes mapas se mostraram como instrumentos profícuos para auxiliar no entendimento das dificuldades e potencialidades de cada discente, bem como da totalidade dos integrantes do curso. O desenho dos mapas permite que se identifiquem os interesses dos discentes, os temas que os motivam, as dificuldades que possam estar enfrentando e as possibilidades de novos encaminhamentos no processo de ensino e aprendizagem, potencializando aprendizagens ativas, cooperativas e autônomas.
Mapeamento Sistemático sobre Plataformas de Ensino da Língua Japonesa
Authors: Neves Bernardo Karoline , Rousy Dias da Silva Danielle
Published: February 2020

Estudar uma segunda ou terceira língua é uma coisa comum nos dias atuais. Algumas pessoas, seja por afinidade com a cultura, oportunidades de emprego ou por querer  aprender  uma  língua  diferente,  escolhem  aprender  a  língua  Japonesa.  Para atender essa demanda que veio crescendo nas últimas décadas, foram desenvolvidos softwares para o ensino de língua, que são opções mais versáteis e mais acessíveis do que as aulas tradicionais. Para desenvolver novos softwares e aplicações, é necessário compreender o estado da arte nesta área. Este trabalho tem como objetivo analisar e compreender o que tem sido desenvolvido nos últimos cinco anos em relação às plataformas computacionais para o aprendizado da língua japonesa. Para atingir este objetivo, foi feito um estudo exploratório através de mapeamento sistemático. Após o processo do mapeamento chegamos à conclusões à respeito do aspecto da língua ensinada, metodologia de ensino, público-alvo, tecnologias utilizadas e presença de adaptação, traçando o panorama geral e identificando áreas a serem exploradas futuramente.
Leitura de ondas cerebrais como ferramenta para escolha das melhores práticas pedagógicas por parte dos docentes: um estudo quase experimental com estudantes do ensino superior
Authors: Bohm Machado Giovanni , Krug Wives Leandro
Published: February 2020

O objetivo deste estudo foi identificar, dentre três métodos/ferramentas/formas distintas de ensino, quais despertam maior interesse e retém a atenção dos estudantes do ensino superior. Com essa finalidade, foi realizado um quase experimento com 57 estudantes de curso superior de uma Universidade privada da região metropolitana de Porto Alegre entre os anos de 2018 e 2019. Foi utilizado um aparelho medidor de ondas cerebrais chamado Mindwave NeuroSky para registrar os níveis de atenção e concentração em diferentes tipos de aulas: expositivas, vídeo e gamificadas. Após testes estatísticos de comparação entre os grupos estudados, os principais resultados indicaram maior efetividade para vídeo-aulas e aulas gamificadas, com aulas expositivas ficando em último lugar.
CONTRIBUIÇÃO DO OBJETO DE APRENDIZAGEM “ORGÃOS DO SENTIDO” PARA ALUNOS COM DEFICIÊNCIA INTELECTUAL
Authors: Regina Schmengler Angélica , Cláudia Oliveira Pavão Ana , Maria de Oliveira Pavão Sílvia
Published: February 2020

O desenvolvimento tecnológico e a inclusão de alunos com deficiência no ensino regular têm demandado que professores desenvolvam e utilizem recursos digitais para auxiliar a aprendizagem dos alunos. Dentre os recursos, destacam-se os objetos de aprendizagem-OA. Este estudo tem como objetivo verificar como um OA contribui para o aprendizado de alunos com deficiência intelectual-DI. A pesquisa é qualitativa, descritiva, do tipo estudo de caso, sendo realizada a observação participante em uma escola pública do interior do estado do Rio Grande do Sul. Os sujeitos são dois alunos do terceiro ano do ensino fundamental. Os dados foram elencados em três categorias e analisados qualitativamente. Os resultados evidenciaram que o OA proporciona motivação, sobretudo pelo feedback, ao contemplar o lúdico por meio de imagens interativas; os recursos de acessibilidade, áudios explicativos e textos objetivos, de fácil compreensão, permitiram melhor interação com os estudantes, sendo possível verificar o potencial de aprendizagem do OA. Pode-se concluir que o OA contribuiu para a aprendizagem dos alunos com DI, a partir da ressignificação das respostas apresentadas.
Evaluation of Usability and Gameplay of Games on Mobile Platforms for Young People on Oncological Treatment
Authors: Theisen Schneider Guilherme , Nice Ferrari Barbosa Débora , Ricardo dos Santos Paulo , Luís Victória Barbosa Jorge
Published: February 2020

This paper presents a method to evaluate usability and gameplay efficiency for educational games developed for children undergoing cancer treatment, as well as a case study involving the game “Corrida Gramatical”. The methodology of this paper consists of the use of tablets by patients aged 10 to 15 years old to evaluate and quantify the usability and gameplay of the game, while the process is documented through non-participant observation, a System Usability Scale (SUS) questionnaire and a semi-structured interview. The proposed method has proved to be supportive in the evaluation of existing educational games, considering the participants of the research, as well as in the improvement of the game by analyzing the flaws identified in the game design. For future studies, we intend to change the inclusion criteria to select a larger group of patients and reaffirm the effectiveness of the proposed method.
Gamificação no Processo de Ensino e Aprendizagem de Estudantes Surdos: uma revisão sistemática
Authors: Otavio Rodrigues Mendes Luiz , José Alves Bueno Alcione , Da Silva Dessbesel Renata , De Carvalho Rutz da Silva Sani
Published: February 2020

Este estudo investiga as potencialidades e fragilidades da gamificação no processo de ensino e aprendizagem de estudantes surdos, a partir de uma revisão sistemática da literatura em artigos, teses e dissertações disponíveis nas bases de dados SciELO, Science Direct, ERIC, Scopus, Web Of Science, IEEE Xplore Digital Library, Advanced Technologies & Aerospace Database, Teses e Dissertações CAPES e Biblioteca Digital Brasileira de Teses e Dissertações por meio dos descritores gamificação e surdos. Os resultados mostraram que as potencialidades em utilizar a gamificação na educação de alunos surdos estão relacionadas à utilização dos elementos dos games como agentes potencializadores (motivação, interação e aumento do interesse dos estudantes no desenvolvimento das tarefas) para contribuir em sua formação. A gamificação é abordada de forma inclusiva, auxiliando na compreensão de conceitos das diversas áreas do conhecimento e na aprendizagem da língua de sinais como meio de comunicação.
LabMorfoQuiz: um Aplicativo Gamificado como Recurso para Aprendizagem em Cursos Superiores de Saúde
Authors: Fernando Andrade Matos Luiz , Rodrigues Costa Acácia , De Oliveira Siqueira Grazielle , Alves dos Santos Menezes Jéssica , Ferreira Neves Danilo , Cerqueira Santos Lidiany
Published: February 2020

Dispositivos móveis fazem parte do cotidiano dos estudantes, entretanto como recurso de aprendizagem ainda desafiam docentes e gestores a integrá-los ao ambiente educacional. A gamificação na educação permite o desenvolvimento da criatividade, imaginação, pensamento lógico e aprendizado lúdico. Diante disso, surgem propostas para adoção da gamificação, associada ao uso de dispositivos móveis, criando-se aplicativos com jogos digitais como estratégia para promover a aprendizagem ativa. Este artigo apresenta o projeto, desenvolvimento e avaliação do LabMorfoQuiz, um aplicativo móvel gamificado para apoiar estudantes de disciplinas iniciais de cursos da saúde na Universidade Federal de Sergipe. Para desenvolver o LabMorfoQuiz foi utilizada a plataforma App Inventor. Em um experimento para avaliação da jogabilidade e experiência do jogador, com participação de 30 discentes, estes consideraram o aplicativo fácil de jogar, declararam-se motivados, interessados e consideraram o conteúdo do jogo relevante.
Mapeamento Sistemático sobre o desenvolvimento e a utilização de Jogos e Simuladores no ensino de Redes de Computadores
Authors: Da Silveira Júnior Garibaldi , D. Medina Roseclea , R Barbieri Dutra Lima Paulo , Eder da Rocha Mazzuco Alex
Published: February 2020

As disciplinas que abrangem o conhecimento de redes de computadores, presentes na maioria dos cursos técnicos e superiores da área de informática, tendem a possuir uma abordagem teórica na maior parte do tempo, visto que o alto custo dos equipamentos de rede muitas vezes impossibilita a prática. Jogos e simuladores podem representar uma alternativa viável para o ensino destes conteúdos, onde práticas reais podem ser feitas diretamente no ambiente virtual simulado. Este trabalho teve como objetivo analisar como estão sendo desenvolvidos e utilizados jogos e simuladores para o ensino de redes de computadores. O processo foi realizado no formato de um mapeamento sistemático, que resultou no total de 27 artigos. onde foi verificado quais tecnologias foram utilizadas no desenvolvimento dos mesmos, para qual plataforma eles foram desenvolvidos, e quais conteúdos educacionais são utilizados.