bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of the metro tunnel project tunnel linings for fire testing
Authors: Guerrieri Maurice , Sanabria Carlos , Lee Wei Ming , Pazmino Esteban , Patel Rahul
Published: August 2020

With a growing pipeline of major transport infrastructure projects transforming Victoria's road and rail networks, there is an increase in demand for the construction of underground tunnels using the shield tunneling method. Such tunnels need to be designed for fire resistance in order to preserve both structural integrity and serviceability in the event of a fire event. This paper describes the approach taken to design the concrete tunnel lining segments for Melbourne's Metro Tunnel Project for structural stability during a severe fire incident. Two types of fire testing programs were implemented, both of which used the RABT ZTV (rail) fire curve. The first involved the fire testing of 12 unloaded flat panels in order to determine whether a particular concrete mix design would be susceptible to spalling. Second, six prototype full scale tunnel lining segments were subjected to full scale structural fire testing, for the first time in Australia. The results indicated that full scale structurally loaded fire tests are essential as unloaded flat panels underestimate the degree of spalling. Addition of PP fibers are successful in mitigating spalling in addition to using pozzolans cements such as flyash and slag.
Vibration analysis of third generation nuclear power plant considering soil‐structure‐interaction effect under the impact of large commercial aircraft
Authors: Li Jianbo , Mei Runyu , Wang Yougang , Lin Gao , Pan Rong
Published: August 2020

Despite the rapid development of nuclear power, the risk of unforeseen beyond‐design‐basis events has become a major concern for nuclear power plant (NPP) operators such as malicious aircraft impacts (AIs). This paper aims to perform vibration analysis on a Generation III NPP subjected to a large commercial aircraft crash, considering soil‐structure‐interaction (SSI) effect. Based on the verified finite element (FE) models of the aircraft Airbus A340 and the NPP, the whole collision process is reproduced numerically by adopting the missile‐target‐interaction method. The selection of soil type was based on AP1000 six‐design soil sites, and five of which were selected for this study. The effect of impact direction, impact height, and embedment is also considered. Results showed that the soil type has a significant effect on the vibration response of points on the base‐mat. Generally, the flexibility of soil increases the response of these points. In the process of propagation, the more flexible the soil is, the faster the weakening range will be. Different impact location will have great influence on the AI‐induced vibration intensity of some areas of the NPP, such as the base‐mat in the shield building. Increasing embedded depth reduces the response of points on the base‐mat.
Cogging Torque Computation and Optimization in Dual‐Stator Axial Flux Permanent Magnet Machines
Authors: Li Qiaoshan , Zhang Bingyi , Liu Aimin
Published: August 2020

Combining Schwarz–Christoffel transformation, magnetic field reconstruction method, and Maxwell stress tensor method, the calculation model of cogging torque of a dual‐stator axial flux permanent magnet machine is established. The end effect and slotting effect are both been taken into account. The results are verified by finite element method. And with the proposed method, calculation time can be significantly reduced compared with finite element method. Three measures to reduce the cogging torque of dual‐stator axial flux permanent magnet machines are discussed based on which the cogging torque is optimized by genetic algorithm. © 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
An ecofriendly synthesized gold nanoparticles induces cytotoxicity via apoptosis inHepG2cells
Authors: Nandhini Joseph T. , Ezhilarasan Devaraj , Rajeshkumar Shanmugam
Published: August 2020

Microbes have long been used for the synthesis of a variety of nanoparticles. Hepatocellular carcinoma (HCC) is the primary liver cancer and it is the second leading cause of cancer‐related mortality worldwide. In this study, we have synthesizedEnterococcusmediated gold nanoparticles (AuNPs) and investigated their cytotoxic potential against human hepatocellular cancer cell line (HepG2). AuNPs were synthesized usingEnterococcussp. RMAA. HepG2 cells were treated with different concentrations of AuNPs for 24 hours and cytotoxicity was analyzed by MTT ((4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay. AuNPs induced reactive oxygen species expression was analyzed by 2′,7′‐dichlorodihydrofluorescein diacetate staining. Morphological changes related to apoptosis was analyzed by annexin V/propidium iodide staining. Protein expression of proliferating cell nuclear antigen (PCNA) was done by western blotting analysis. Bacterial‐mediated AuNPs caused significant cytotoxicity in HepG2 cells. AuNPs treatment also caused the significant expression of ROS and morphological damage related to apoptosis. AuNPs treatments were responsible for the dislocation of cytochrome c from mitochondria to cytosol. The protein expression of PCNA was significantly decreased upon AuNPs treatment. These findings suggest thatEnterococcus‐mediated AuNPs can inhibit the proliferation of HepG2 cells via intracellular ROS mediated apoptosis, decreased PCNA expressions, and it may have the potential to treat HCC.
Enzymatic hydrolysis behavior on malt bagasse for fermentative sugar disposal in thermostatic and ultrasonic bath
Authors: Artifon Wagner , Dalastra Caroline , Kubeneck Simone , Klanovicz Natalia , Luzzi Siane Camila , Mazutti Marcio A. , Priamo Wagner L. , Bender João Paulo , Alves Sérgio L. , Fongaro Gislaine , Treichel Helen
Published: August 2020

This study evaluated the effect of enzymatic hydrolysis on malt bagasse for fermentative sugar extraction in thermostatic and ultrasonic bath. The enzymatic reaction was performed using cellulase, α‐amylase, and amyloglucosidase (in separate and combined) on malt bagasse to analyze the hydrolysis effect. For this, a central composite rotational design was applied to evaluate the effect of solid:liquid (malt bagasse w/v) versus enzymatic concentration, considering cellulase, α‐amylase, and amyloglucosidase enzymes in mix solution, on fermentable sugars liberation. Then the kinetic fermentative sugars liberation was evaluated in a hydrolysis reaction using cellulase, α‐amylase, and amyloglucosidase (in separate and combined) after exposure in thermostatic and ultrasonic bath. From enzymatic mix, the maximum total reducing sugar (TRS) yield was 408.8 and 219.9 mg·g−1 in thermostatic and in ultrasound bath, respectively. Kinetic studies showed a TRS variation of 6 to 7 g·L−1 for all enzymes. Amyloglucosidase was more promising in assimilation of malt bagasse, responsible for 43% of sugar releasing. Briefly, a low‐cost procedure using thermostatic bath improved the hydrolysis reaction. The results from the experiments present a new application where malt bagasse can be employed showing the potential of this brewing industry residue in fomenting processes, as bioethanol production.
Asking Questions Is Just the First Step: Using Upward and Downward Scaffolds
Authors: Zucker Tricia A. , Cabell Sonia Q. , Oh Yoonkyung , Wang Xiaoning
Published: August 2020

Theory and research have demonstrated the importance of teacher scaffolding to facilitate effective classroom conversations during shared book reading. When teachers scaffold conversations, young students can develop language skills more quickly. The authors describe a scaffolding framework and findings from research on how open‐ended questions provide the first step in facilitating extended conversations that adjust scaffolding upward and downward to match student responses. The authors then outline suggestions for how teachers can scaffold conversations during shared book reading.
Normal cavum veli interpositi at 14–17 gestational weeks: three‐dimensional and Doppler transvaginal neurosonographic study
Authors: Birnbaum R. , Barzilay R. , Brusilov M. , Wolman I. , Malinger G.
Published: August 2020

Objectives

To provide evidence to support the hypothesis that the midline cyst‐like fluid collection that is frequently observed on fetal brain ultrasound (US) imaging during the early second trimester represents a normal transient cavum veli interpositi (CVI).

Methods

This was a retrospective analysis of 89 three‐dimensional normal fetal brain volumes, acquired by transvaginal US imaging in 87 pregnant women between 14 and 17 gestational weeks. The midsagittal view was studied using multiplanar imaging, and the maximum length of the fluid collection located over (dorsal to) the tela choroidea of the third ventricle was measured. We calculated the correlation of the transverse cerebellar diameter (TCD) and of the maximum length of the fluid collection with gestational age according to last menstrual period. Color Doppler images were analyzed to determine the location of the internal cerebral veins with respect to the location of the fluid collection. Reports of the second‐trimester anatomy scan at 22–24 weeks were also reviewed.

Results

Interhemispheric fluid collections of various sizes were found in 55% (49/89) of the volumes (mean length, 5 (range, 3.0–7.8) mm). There was a strong correlation between TCD and gestational age (Pearson's correlation, 0.862; P < 0.001). There was no correlation between maximum fluid length and gestational age (Pearson's correlation, –0.442; P = 0.773). Color Doppler images were retrieved in 32 of the 49 fetuses; in 100% of these, the internal cerebral veins coursed within the echogenic roof of the third ventricle. The midline structures were normal at the 22–24‐week scan in all cases.

Conclusions

In approximately half of normal fetuses, during the evolution of the midline structures of the brain, various degrees of fluid accumulate transiently in the velum interpositum, giving rise to a physiologic CVI. Patients should be reassured that this is a normal phenomenon in the early second trimester that, if an isolated finding, has no influence on fetal brain development. © 2020 International Society of Ultrasound in Obstetrics and Gynecology
Doppler changes in umbilical artery, middle cerebral artery, cerebroplacental ratio and ductus venosus during open fetal microneurosurgery for intrauterine open spina bifida repair
Authors: Cruz‐Martínez R. , Gámez‐Varela A. , Cruz‐Lemini M. , Martínez‐Rodríguez M. , Luna‐García J. , López‐Briones H. , Chavelas‐Ochoa F. , Chávez‐González E. , Aguilar‐Vidales K. , Chávez‐Vega J. , Castelo‐Vargas A. , Rivera‐Carrillo P. , Hernández‐Andrade E.
Published: August 2020

Objective

To describe changes in fetal Doppler parameters during a novel technique for open fetal microneurosurgery for open spina bifida (OSB) repair.

Methods

This was a prospective study of 44 fetuses undergoing open fetal surgery for OSB repair using a novel microneurosurgery approach that is characterized by a mini‐hysterotomy (diameter of 15 mm), minimal fetal manipulation and maintenance of a constant normal amniotic fluid volume throughout the procedure. Doppler velocimetry of the umbilical artery (UA), fetal middle cerebral artery (MCA) and ductus venosus (DV) was performed before the start of surgery and at prespecified timepoints during fetal surgery. UA pulsatility index (PI) > 95th percentile, DV‐PI > 95th percentile, MCA‐PI < 5th percentile and cerebroplacental ratio (CPR) < 5th percentile were considered abnormal.

Results

Median gestational age at fetal surgery was 25.2 weeks (range, 22.9–27.9 weeks). Doppler recordings were successfully obtained in all cases during all timepoints throughout the surgery. As compared with Doppler values before surgery, there was a significant increase in the proportion of fetuses with MCA‐PI < 5th percentile (63.6% vs 13.6%; P < 0.001), CPR < 5th percentile (65.9% vs 15.9%; P < 0.001) and DV‐PI > 95th percentile (22.7% vs 0%; P = 0.01) and a non‐significant increase in the proportion of fetuses with UA‐PI > 95th percentile (11.4% vs 0%; P = 0.12) during fetal surgery. None of the fetuses showed absent or reversed end‐diastolic velocity in the UA or absent or reversed DV a‐wave at any stage during OSB repair. All abnormal Doppler parameters returned to normal after surgery.

Conclusions

During open fetal surgery for OSB repair, a small hysterotomy, reduced fetal manipulation and maintenance of a normal amniotic fluid volume seem to prevent severe fetal Doppler abnormalities. The mild Doppler changes observed during fetal surgery could be a manifestation of fetal adaptation to the stress of fetal surgery. © 2020 International Society of Ultrasound in Obstetrics and Gynecology
Heterogeneity in defining fetal corpus callosal pathology: systematic review
Authors: Mahallati H. , Sotiriadis A. , Celestin C. , Millischer A. E. , Sonigo P. , Grevent D. , O'Gorman N. , Bahi‐Buisson N. , Attié‐Bitach T. , Ville Y. , Salomon L. J.
Published: August 2020

Objective

Fetal anomalies of the corpus callosum (CC) have been reported in the prenatal imaging literature since 1985, and, especially when isolated, pose challenges for both the patient and fetal medicine specialist. The purpose of this study was to review systematically the literature on prenatally diagnosed abnormalities of the CC, focusing on the terminology used to describe abnormalities other than complete agenesis of the CC, and to assess the heterogeneity of the nomenclature and definitions used.

Methods

This study was conducted in accordance with the PRISMA statement for reporting systematic reviews. A literature search was performed to identify prospective or retrospective case series or cohort studies, published in English, French, Italian, German or Spanish, reporting fetal imaging findings and describing anomalies of the CC. Quality and risk of bias of the studies were evaluated using the Newcastle–Ottawa scale and a modification of the scale developed by Conde‐Agudelo et al. for other fetal imaging studies. The data extracted included the number of patients, the number of different anomalies identified, the descriptive names of the anomalies, and, where applicable, the definitions of the anomalies, the number of cases of each type of anomaly and the biometric charts used. Secondary tests used to confirm the diagnosis, as well as the postnatal or post‐termination tests used to ascertain the diagnosis, were also recorded.

Results

The search identified 998 records, and, after review of titles and abstracts and full review of 45 papers, 27 studies were included initially in the review, of which 24 were included in the final analysis. These 24 studies had a broad range of quality and risk of bias and represented 1135 cases of CC anomalies, of which 49% were complete agenesis and the remainder were described using the term partial agenesis or nine other terms, of which five had more than one definition.

Conclusions

In comparison to the postnatal literature, in the prenatal literature there is much greater heterogeneity in the nomenclature and definition of CC anomalies other than complete agenesis. This heterogeneity and lack of standard definitions in the prenatal literature make it difficult to develop large multicenter pooled cohorts of patients who can be followed in order to develop a better understanding of the genetic associations and neurodevelopmental and psychological outcomes of patients with CC anomalies. As this information is important to improve counseling of these patients, a good first step towards this goal would be to develop a simpler categorization of prenatal CC anomalies that matches better the postnatal literature. © 2020 International Society of Ultrasound in Obstetrics and Gynecology
Bayesian modeling of the mind: From norms to neurons
Authors: Rescorla Michael
Published: August 2020

Bayesian decision theory is a mathematical framework that models reasoning and decision‐making under uncertain conditions. The past few decades have witnessed an explosion of Bayesian modeling within cognitive science. Bayesian models are explanatorily successful for an array of psychological domains. This article gives an opinionated survey of foundational issues raised by Bayesian cognitive science, focusing primarily on Bayesian modeling of perception and motor control. Issues discussed include the normative basis of Bayesian decision theory; explanatory achievements of Bayesian cognitive science; intractability of Bayesian computation; realist versus instrumentalist interpretation of Bayesian models; and neural implementation of Bayesian inference.

This article is categorized under:

Philosophy > Foundations of Cognitive Science
Contaminated aquatic sediments
Authors: Hossain Fahim
Published: August 2020

Aquatic sediments are contaminated by different anthropogenic activities and natural deposition. This review manuscript has discussed on published manuscript in 2019 based on monitoring and identification of contaminants, GIS application and isotopic evaluation for monitoring of pollutants, physicochemical and biochemical fate and transport of the pollutants as well as remediation and toxicity analysis so that environmental and ecological impacts due to pollution can be minimized.
Combating disinformation in a social media age
Authors: Shu Kai , Bhattacharjee Amrita , Alatawi Faisal , Nazer Tahora H. , Ding Kaize , Karami Mansooreh , Liu Huan
Published: August 2020

The creation, dissemination, and consumption of disinformation and fabricated content on social media is a growing concern, especially with the ease of access to such sources, and the lack of awareness of the existence of such false information. In this article, we present an overview of the techniques explored to date for the combating of disinformation with various forms. We introduce different forms of disinformation, discuss factors related to the spread of disinformation, elaborate on the inherent challenges in detecting disinformation, and show some approaches to mitigating disinformation via education, research, and collaboration. Looking ahead, we present some promising future research directions on disinformation.

This article is categorized under:

Algorithmic Development > Multimedia

Commercial, Legal, and Ethical Issues > Social Considerations

Application Areas > Education and Learning
Hydrological Management for Submersed Aquatic Vegetation in South Carolina Coastal Impoundments
Authors: Bauer Beau A. , Kaminski Richard M. , Lanham J. Drew , Gerard Patrick D. , Wiggers Ernie P.
Published: August 2020

We conducted a field experiment to test effects of complete drawdown to dried substrates versus partial (shallow water, 0–10 cm) drawdown on widgeongrass (Ruppia maritima) and other native submersed aquatic vegetation (SAV) biomass (dry) in managed brackish tidal impoundments (hereafter, impoundments) in the Ashepoo, Combahee, and Edisto Rivers Basin, South Carolina, USA. We sampled SAV in 20 impoundments (complete drawdown, n = 8; partial drawdown, n = 12) during August 2016, November 2016, January 2017, and April 2017. We detected a drawdown effect on SAV biomass for August 2016 samples before Hurricane Matthew in October 2016, which subsequently confounded drawdown treatment effects. Mean SAV biomass in August 2016 was nearly 4 times greater in partially drawndown ( = 35.98 g/m2 ± 6.05 [SE]) than completely drawndown impoundments ( = 9.52 g/m2 ± 7.41). We suggest partial drawdowns to promote SAV biomass in coastal South Carolina and other south Atlantic brackish wetlands. We also encourage managers to conduct complete drawdowns periodically to reduce flocculent soils and organic matter and promote rooting by SAV. Our results may aid the Atlantic Coast Joint Venture of the North American Waterfowl Management Plan to estimate potential energetic carrying capacity of brackish impoundments in South Carolina and elsewhere as applicable for wintering ducks and American coots (Fulica americana), and to illustrate the effect of a hurricane that decreases SAV biomass in impounded wetlands. © 2020 The Wildlife Society.
LOCAL FORMULAS FOR MULTIPLICATIVE FORMS
Authors: CABRERA A. , MĂRCUŢ I. , SALAZAR M. A.
Published: August 2020

We provide explicit formulas for integrating multiplicative forms on local Lie groupoids in terms of infinitesimal data. Combined with our previous work [8], which constructs the local Lie groupoid of a Lie algebroid, these formulas produce concrete integrations of several geometric stuctures defined infinitesimally. In particular, we obtain local integrations and non-degenerate realizations of Poisson, Nijenhuis–Poisson, Dirac, and Jacobi structures by local symplectic, symplectic-Nijenhuis, presymplectic, and contact groupoids, respectively.
Purpura anularis teleangiectodes
Authors: Burghaus Jana , Enk Alexander , Toberer Ferdinand
Published: August 2020

Die Purpura anularis teleangiectodes (PAT) ist eine seltene Erkrankung aus dem Spektrum der hämorrhagisch pigmentierten Dermatosen, die vorzugsweise junge Frauen betrifft und klinisch durch symmetrische, anuläre Erytheme mit Teleangiektasien an der unteren Extremität imponiert. Histologisch zeigen sich oberflächlich dermal gelegene Erythrozytenextravasate begleitet von einem lymphozytären Entzündungsinfiltrat. Als Auslöser können häufig Medikamente identifiziert werden. In idiopathischen Fällen werden kortisonhaltige Externa eingesetzt. Auch eine Kompressionsbehandlung kann unterstützend sinnvoll sein.
Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBROb/Ob mice
Authors: Qiu Jiedong , Albrecht Thomas , Zhang Shiqi , Hauske Sibylle J. , Rodriguez-Niño Angelica , Zhang Xinmiao , Nosan Darya , Pastene Diego O. , Sticht Carsten , Delatorre Carolina , van Goor Harry , Porubsky Stefan , Krämer Bernhard K. , Yard Benito A.
Published: August 2020

Objective

To assess the influence of serum carnosinase (CN1) on the course of diabetic kidney disease (DKD).

Methods

hCN1 transgenic (TG) mice were generated in a BTBROb/Ob genetic background to allow the spontaneous development of DKD in the presence of serum carnosinase. The influence of serum CN1 expression on obesity, hyperglycemia, and renal impairment was assessed. We also studied if aggravation of renal impairment in hCN1 TG BTBROb/Ob mice leads to changes in the renal transcriptome as compared with wild-type BTBROb/Ob mice.

Results

hCN1 was detected in the serum and urine of mice from two different hCN1 TG lines. The transgene was expressed in the liver but not in the kidney. High CN1 expression was associated with low plasma and renal carnosine concentrations, even after oral carnosine supplementation. Obese hCN1 transgenic BTBROb/Ob mice displayed significantly higher levels of glycated hemoglobin, glycosuria, proteinuria, and increased albumin-creatinine ratios (1104 ± 696 vs 492.1 ± 282.2 μg/mg) accompanied by an increased glomerular tuft area and renal corpuscle size. Gene-expression profiling of renal tissue disclosed hierarchical clustering between BTBROb/Wt, BTBROb/Ob, and hCN1 BTBROb/Ob mice. Along with aggravation of the DKD phenotype, 26 altered genes have been found in obese hCN1 transgenic mice; among them claudin-1, thrombospondin-1, nephronectin, and peroxisome proliferator–activated receptor-alpha have been reported to play essential roles in DKD.

Conclusions

Our data support a role for serum carnosinase 1 in the progression of DKD. Whether this is mainly attributed to the changes in renal carnosine concentrations warrants further studies.

Key messages

Increased carnosinase 1 (CN1) is associated with diabetic kidney disease (DKD).

BTBROb/Ob mice with human CN1 develop a more aggravated DKD phenotype.

Microarray revealed alterations by CN1 which are not altered by hyperglycemia.

These genes have been described to play essential roles in DKD.

Inhibiting CN1 could be beneficial in DKD.
Stellenwert des „Stone-heart“-Phänomens bei Herz-Kreislauf-Stillstand
Authors: Unseld J. , Pflüger Patrick , Landeg Maximilian , Dommasch Michael , Kanz K.‑G. , Bogner-Flatz V.
Published: August 2020

Der Begriff Stone heart ist definiert als systolische Kontraktur des Herzens und wird auch als kontraktiler Herzstillstand bezeichnet. Er wurde erstmals 1972 durch den US-amerikanischen Herzchirurgen Denton Cooley bei Patienten mit Bypass-Operation beschrieben. Das Stone heart ist meist Folge eines prolongierten Herz-Kreislauf-Stillstands, welcher zu einer Anoxie bzw. Hypoxie des Myokards führt. Es wird über 3 Traumapatienten berichtet, welche nach kardiopulmonaler Reanimation in der postmortalen Computertomographie (CT) ein Stone-heart-Phänomen zeigten.
Evaluation of the belt punching process efficiency based on the resistance force of the compressed material
Authors: Wojtkowiak Dominik , Talaśka Krzysztof , Wilczyński Dominik
Published: August 2020

Vacuum conveyor belt punching process by using the piercing punch which cooperates with the die has potential to be modified in aspects of lowering the perforation force, extending the tool life, and improving the hole quality in the perforated belts. All these parameters have an influence on the efficiency of the process and strictly depends on the punch geometry. This indicates that based on these criteria the optimization of the tool constructional features may be performed. In the presented research, authors have shown the linear correlation between the resistance force of the compressed material of the multilayer polymer composite belt in punching and the efficiency of the process. It was also proved that using the effective geometry of the piercing punch with spherical bowl can reduce the perforation force by 69%. Based on the obtained model, the simplified optimization as well as the evaluation of the punches with defined geometry can be performed, since all characteristics of the material compressive force obtained for the effective punches were almost consistent. For proper analysis, it is necessary to use the combination of the analytical and numerical modelling, computer simulations with using the finite element method (FEM) and the experimental tests. However, by performing simple compression tests for various tool geometry on the strength testing machine, it is possible to perform the comparison analysis of different piercing punches based on the derived models. This approach can be used to evaluate the properties of selected tools for the groups of materials with wide divergence of the mechanical properties without performing the complex research.
Sacral neuromodulation to treat voiding dysfunction in patients with previous pelvic surgery for deep infiltrating endometriosis: our centre's experience
Authors: Agnello Marco , Vottero Mario , Bertapelle Paola
Published: August 2020

Introduction and hypothesis

Voiding symptoms/dysfunctions (VS/Ds) after surgery for deep-infiltrating endometriosis (DIE) are frequent (20% of patients) and, together with bowel dysfunctions, may represent a de novo disorder due to surgical damage of the pelvic plexus or a worsening of pre-existent functional damage. Sacral neuromodulation (SNM) might improve voiding symptoms by treating dysfunctional voiding. The aim of this study is to report our experience with SNM in patients treated with surgery for DIE.

Methods

We retrospectively enrolled 13 patients with VS/Ds after surgery for DIE. All patients were investigated with urodynamic studies (UDS) and agreed to undergo SNM. Pre-existing VS/Ds, bowel disorders and pelvic pain, DIE surgical procedures, UDS and SNM test results were recorded.

Results

After surgery for DIE, functional bladder outflow obstruction and detrusor acontractility were observed in nine and four patients, respectively. Chronic pelvic pain was present in seven cases. Twelve patients developed constipation, whilst one patient had de novo faecal incontinence. After the SNM testing period, nine patients (69.2%) experienced a significant improvement of symptoms that led to definitive implant. Four patients (30.8%) had no symptom relief and the system was removed.

Conclusions

Functional bladder outflow obstruction and urinary retention are the most common VS/Ds after surgery for DIE. SNM may be an effective option for these patients, probably due to its action in improving the dysfunctional voiding, which was likely to be already present as part of the “endometriotic syndrome” and got worse after pelvic surgery. Results for pelvic pain control and gastrointestinal disorders should not be underestimated.
The fibration method over real function fields
Authors: Pál Ambrus , Szabó Endre
Published: August 2020

Let$$\mathbb R(C)$$R(C)be the function field of a smooth, irreducible projective curve over$$\mathbb R$$R. LetXbe a smooth, projective, geometrically irreducible variety equipped with a dominant morphismfonto a smooth projective rational variety with a smooth generic fibre over$$\mathbb R(C)$$R(C). Assume that the cohomological obstruction introduced by Colliot-Thélène is the only one to the local-global principle for rational points for the smooth fibres offover$$\mathbb R(C)$$R(C)-valued points. Then we show that the same holds forX, too, by adopting the fibration method similarly to Harpaz–Wittenberg.
Homotopical and operator algebraic twisted K-theory
Authors: Hebestreit Fabian , Sagave Steffen
Published: August 2020

Using the framework for multiplicative parametrized homotopy theory introduced in joint work with C. Schlichtkrull, we produce a multiplicative comparison between the homotopical and operator algebraic constructions of twistedK-theory, both in the real and complex case. We also improve several comparison results about twistedK-theory of$$C^*$$C∗-algebras to include multiplicative structures. Our results can also be interpreted in the$$\infty $$∞-categorical setup for parametrized spectra.
Direct sample introduction GC-MS/MS for quantification of organic chemicals in mammalian tissues and blood extracted with polymers without clean-up
Authors: Baumer Andreas , Escher Beate I. , Landmann Julia , Ulrich Nadin
Published: August 2020

Solvent extracts of mammalian tissues and blood contain a large amount of co-extracted matrix components, in particular lipids, which can adversely affect instrumental analysis. Clean-up typically degrades non-persistent chemicals. Alternatively, passive sampling with the polymer polydimethylsiloxane (PDMS) has been used for a comprehensive extraction from tissue without altering the mixture composition. Despite a smaller fraction of matrix being co-extracted by PDMS than by solvent extraction, direct analysis of PDMS extracts was only possible with direct sample introduction (DSI) GC-MS/MS, which prevented co-extracted matrix components entering the system. Limits of quantitation (LOQ) ranged from 4 to 20 pg μL−1ethyl acetate (PDMS extract) for pesticides and persistent organic pollutants (POPs). The group of organophosphorus flame retardants showed higher LOQs up to 107 pg μL−1due to sorption to active sites at the injection system. Intraday precision ranged between 1 and 10%, while the range of interday precision was between 1 and 18% depending on the analyte. The method was developed using pork liver, brain, and fat as well as blood and was then applied to analyze human post-mortem tissues where polychlorinated biphenyls (PCBs) as well as dichlorodiphenyltrichloroethane (DDT) and DDT metabolites were detected.
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
Authors: Halvorsen Merete , Edeklev Camilla Sæthre , Fraser-Green Jorunn , Løvland Grethe , Vatnehol Svein Are Sirirud , Gjertsen Øivind , Nedregaard Bård , Sletteberg Ruth , Ringstad Geir , Eide Per Kristian
Published: August 2020

Purpose

Magnetic resonance imaging (MRI) contrast agents have been used off-label for diagnosis of cerebrospinal fluid (CSF) leaks and lately also for assessment of the glymphatic system and meningeal lymphatic drainage. The purpose of this study was to further evaluate the short- and long-term safety profile of intrathecal MRI contrast agents.

Methods

In this prospective study, we compared the safety profile of different administration protocols of intrathecal gadobutrol (GadovistTM; 1.0 mmol/ml). Gadobutrol was administered intrathecal in a dose of 0.5 mmol, with or without iodixanol (VisipaqueTM 270 mg I/ml; 3 ml). In addition, a subgroup was given intrathecal gadobutrol in a dose of 0.25 mmol. Adverse events were assessed at 1 to 3 days, 4 weeks, and after 12 months.

Results

Among the 149 patients, no serious adverse events were seen in patients without history of prior adverse events. The combination of gadobutrol with iodixanol did not increase the occurrence of non-serious adverse events after days 1–3. Intrathecal gadobutrol in a dose of 0.25 mmol caused less severity of nausea, as compared with the dose of 0.5 mmol. The clinical diagnosis was the major determinant for occurrence of non-serious adverse events after intrathecal gadobutrol.

Conclusion

This prospective study showed that intrathecal administration of gadobutrol in a dose of 0.5 mmol is safe. Non-serious adverse events were to a lesser degree affected by the administration protocols, though preliminary data are given that side effects of intrathecal gadobutrol are dose-dependent.
Direct puncture of the carotid artery as a bailout vascular access technique for mechanical thrombectomy in acute ischemic stroke—the revival of an old technique in a modern setting
Authors: Miszczuk Milena , Bauknecht Hans Christian , Kleine Justus F. , Liebig Thomas , Bohner Georg , Siebert Eberhard
Published: August 2020

Purpose

To describe our single-center experience of mechanical thrombectomy (MTE) via a direct carotid puncture (DCP) with regard to indication, time metrics, procedural details, as well as safety and efficacy aspects.

Methods

DCP thrombectomy cases performed at our center were retrospectively identified from a prospectively maintained institutional MTE database. Various patient (age, sex, stroke cause, comorbidities), clinical (NIHSS, mRS), imaging (occlusion site, ASPECT score), procedural (indication for DCP, time from DCP to reperfusion, materials used, technical nuances), and outcome data (NIHSS, mRS) were tabulated.

Results

Among 715 anterior circulation MTEs, 12 DCP-MTEs were identified and analyzed. Nine were left-sided M1 occlusions, one right-sided M1 occlusion, and two right-sided M2 occlusions. DCP was successfully carried out in 91.7%; TICI 2b/3-recanalization was achieved in 83.3% via direct lesional aspiration and/or stent-retrieval techniques. Median time from DCP to reperfusion was 23 min. Indications included futile transfemoral catheterization attempts of the cervical target vessels as well as iliac occlusive disease. Neck hematoma occurred in 2 patients, none of which required further therapy.

Conclusion

MTE via DCP in these highly selected patients was reasonably safe, fast, and efficient. It thus represents a valuable technical extension of MTE, especially in patients with difficult access.
Dual-energy CT collagen density mapping of wrist ligaments reveals tissue remodeling in CPPD patients: first results from a clinical cohort
Authors: Ziegeler Katharina , Richter Sophia-Theresa , Hermann Sandra , Hermann Kay Geert A. , Hamm Bernd , Diekhoff Torsten
Published: August 2020

Objectives

To evaluate differences in collagen density as detected by dual-energy computed tomography (DECT) of wrist ligaments between patients with calcium pyrophosphate-dihydrate deposition disease (CPPD) and a control group in order to gain insight into changes of the extracellular matrix in response to crystal deposition.

Materials and methods

This retrospective study included 28 patients (18 with CPPD, 10 controls) who underwent DECT of the wrist. Collagen density maps were reconstructed from the DECT datasets and used to measure densities in regions of interest (ROIs) placed in the scapholunate (SL) ligament (dorsal, palmar, proximal), lunotriquetral (LT) ligament, and extensor carpi radialis (ECR) tendon, (n = 260 measurements). The presence of calcifications on standard CT images in these regions was assessed by a blinded reader. Densities were compared with nonparametric tests, and linear regression analysis was performed to investigate the impact of age, sex, and CT- detected calcium deposition on collagen density.

Results

Collagen density in the SL ligament was significantly higher in CPPD patients than in controls (overall mean: 265.4 ± 32.1 HU vs. 196.3 ± 33.8 HU;p < 0.001). In the ECR tendon, collagen densities did not differ significantly (p = 0.672): 161.3 ± 20.1 HU in CPPD vs. 163.6 ± 12.0 HU in controls. Regression analysis showed that diagnosis, but not age or calcification, had a significant impact on collagen density.

Conclusion

Collagen density of the SL ligament is significantly higher in CPPD patients than in control patients. Further research is needed to understand these changes in the extracellular matrix of ligaments in CPPD.
Shoulder proprioception following reverse total shoulder arthroplasty
Authors: Walecka Joanna , Lubiatowski Przemysław , Consigliere Paolo , Atoun Ehud , Levy Ofer
Published: August 2020

Joint replacement affects the proprioception, as shown in knees, elbows, and shoulder studies.

Aim

The aim was to evaluate shoulder joint position sense (JPS) following reverse total shoulder arthroplasty (rTSA) for patients with cuff arthropathy.

Methods

Twenty-nine patients that underwent unilateral rTSA (19 females, 10 males) and 31 healthy volunteers evaluated for JPS of shoulder using a dedicated high accuracy electronic goniometer. Error of active reproduction of joint position (EARJP) was assessed at the following reference positions: 30°, 60°, 90°, and 120° for forward flexion and abduction and 15°, 30°, and 45° for internal and external rotation in rTSA, contralateral non-operated, and control shoulders.

Results

Results of EPRJP for rTSA, contralateral, and control (respectively) are as follows:Forward flexion: 30° = (8.0 ± 5.7, 9.8 ± 6.1, and 4.9 ± 3.0), 60° = (5.0 ± 2.8, 5.9 ± 2.7, and 5.1 ± 3.2), 90° = (3.1 ± 1.6, 5.5 ± 2.6, and 3.2 ± 1.4), and 120° = (3.4 ± 2.1, 5.6 ± 4.0, and 3.5 ± 1.7)Abduction: 30° = (5.2 ± 2.5, 9.1 ± 6.1, and 4.6 ± 2.3), 60° = (5.2 ± 3.6, 6.6 ± 4.1, and 5.3 ± 3.1), 90° = (3.8 ± 2.0; 7.4 ± 5.5, and 4.1 ± 1.9), and 120° = (5.3 ± 2.9, 7.7 ± 5.3, and 4.2 ± 1.9)Internal rotation: 15° = (4.3 ± 3.1, 6.2 ± 4.4, and 2.8 ± 1.2), 30° = (3.2 ± 1.9, 4.5 ± 2.3, and 3.3 ± 1.4), and 45° = (3.5 ± 2.0, 4.1 ± 1.8, and 2.8 ± 1.0)External rotation: 15° = (3.0 ± 1.7, 4.2 ± 2.2, and 3.6 ± 1.4) and 30° = (3.1 ± 1.5, 3.8 ± 2.6, and 3.4 ± 1.6)The results showed significantly better JPS (lower EPRJP) in shoulders following rTSA and normal control shoulders comparing with the patient’s contralateral shoulder. The explanation can be that rTSA improves joint kinematics and stability, which allows better muscular performance and proprioception feedback.

Conclusion

Shoulders following rTSA show JPS superior to non-operated contralateral shoulders and comparable with healthy population shoulders. It seems that rTSA restores shoulder proprioception.
Akutes Engwinkelglaukom und Effusionssyndrom nach Phakoemulsifikation
Authors: Anwar M. , Brockmann T. , Walckling M. , Fuchsluger T. A.
Published: August 2020

Eine 72-jährige Patientin entwickelte nach unkomplizierter Kataraktoperation ein beidseitiges sekundäres iridokorneales Engwinkelglaukom bei uvealem Effusionssyndrom. Als Ursache für die Entstehung des Effusionssyndroms konnte die postoperative Einnahme von Acetazolamid ausgemacht werden. Unter Berücksichtigung einer Sulfonamid-freien systemischen und lokalen drucksenkenden sowie antiinflammatorischen Therapie zeigte sich eine schnelle Befundbesserung. Der Fall verdeutlicht eine seltene, aber klinisch schwerwiegende unerwünschte Arzneimittelwirkung von Acetazolamid und zeigt effiziente Therapiemöglichkeiten auf.
The “speed” of acuity in scotopic vs. photopic vision
Authors: Heinrich Sven P. , Blechenberg Torben , Reichel Christoph , Bach Michael
Published: August 2020

Purpose

The effect of duration of optotype presentation on visual acuity measures has been extensively studied under photopic conditions. However, systematic data on duration dependence of acuity values under mesopic and scotopic conditions is scarce, despite being highly relevant for many visual tasks including night driving, and for clinical diagnostic applications. The present study aims to address this void.

Methods

We measured Landolt C acuity under photopic (90 cd/m2), mesopic (0.7 cd/m2), and scotopic (0.009 cd/m2) conditions for several optotype presentation durations ranging from 0.1 to 10 s using the Freiburg Acuity and Contrast Test. Two age groups were tested (young, 18–29 years, and older, 61–74 years).

Results

As expected, under all luminance conditions, better acuity values were found for longer presentation durations. Photopic acuity in young participants decreased by about 0.25 log units from 0.1 to 10 s; mesopic vision mimicked the photopic visual behavior. Scotopic acuities depended more strongly on presentation duration (difference > 0.78 log units) than photopic values. There was no consistent pattern of correlation between luminance conditions across participants. We found a qualitative similarity between younger and older participants, despite higher variability among the latter and differences in absolute acuity: Photopic acuity difference (0.1 vs. 10 s) for the older participants was 0.19 log units, and scotopic difference was > 0.62 log units.

Conclusion

Scotopic acuity is more susceptible to changes in stimulus duration than photopic vision, with considerable interindividual variability. The latter may reflect differences in aging and sub-clinical pathophysiological processes and might have consequences for visual performance during nocturnal activities such as driving at night. Acuity testing with briefly presented scotopic stimuli might increase the usefulness of acuity assessment for tracking of the health state of the visual system.
Innovative approaches for induction of gastrointestinal anastomotic healing: an update on experimental and clinical aspects
Authors: Reischl Stefan , Wilhelm Dirk , Friess Helmut , Neumann Philipp-Alexander
Published: August 2020

Purpose

In most cases, traditional techniques to perform an anastomosis following gastrointestinal resections lead to successful healing. However, despite focused research in the field, in certain high-risk situations leakage rates remain almost unchanged. Here, additional techniques may help the surgeon to protect the anastomosis and prevent leakage. We give an overview of some of the latest developments on experimental and clinical techniques for induction of anastomotic healing.

Methods

We performed a review of the current literature on approaches to improve anastomotic healing.

Results

Many promising approaches with a high clinical potential are in the developmental pipeline. Highly experimental approaches like inhibition of matrix metalloproteinases, stem cell therapy, hyperbaric oxygen therapy, induction of the hypoxic adaptive response, and the administration of growth factors are still in the preclinical phase. Other more clinical developments aim to strengthen the anastomotic suture line mechanically while shielding it from the influence of the microbiome. Among them are gluing, seaming the staple line, attachment of laminar biomaterials, and temporary intraluminal tubes. In addition, individualized bowel preparation, selectively reducing certain detrimental microbial populations could become the next stage of bowel preparation. Compression anastomoses are evolving as an equivalent technique additional to established hand-sewn and stapled anastomoses. Fluorescence angiography and flexible endoscopy could complement intraoperative quality control additionally to the air leak tests. Virtual ileostomy is a concept to prepare the bowel for the easy formation of a stoma in case of leakage.

Conclusion

A variety of promising diagnostic and prophylactic measures that may support the surgeon in identifying high-risk anastomoses and support them according to their potential deficits is currently in development.
Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach
Authors: Sperotto Francesca , Friedman Kevin G. , Son Mary Beth F. , VanderPluym Christina J. , Newburger Jane W. , Dionne Audrey
Published: August 2020

Initial reports on COVID-19 described children as largely spared from severe manifestations, with only 2–6% of children requiring intensive care treatment. However, since mid-April 2020, clusters of pediatric cases of severe systemic hyperinflammation and shock epidemiologically linked with COVID-19 have been reported. This condition was named as SARS-Cov-2-associated multisystem inflammatory syndrome in children and showed similarities to Kawasaki disease. Here, we present a narrative review of cases reported in literature and we discuss the clinical acute and follow-up management of these patients. Patients with SARS-Cov-2-associated multisystem inflammatory syndrome frequently presented with persistent fever, gastrointestinal symptoms, polymorphic rash, conjunctivitis, and mucosal changes. Elevated inflammatory markers and evidence of cytokine storm were frequently observed. A subset of these patients also presented with hypotension and shock (20–100%) from either acute myocardial dysfunction or systemic hyperinflammation/vasodilation. Coronary artery dilation or aneurysms have been described in 6–24%, and arrhythmias in 7–60%. Cardiac support, immunomodulation, and anticoagulation are the key aspects for the management of the acute phase. Long-term structured follow-up of these patients is required due to the unclear prognosis and risk of progression of cardiac manifestations.

Conclusion: Multisystem inflammatory syndrome is a novel syndrome related to SARS-CoV-2 infection. Evidence is still scarce but rapidly emerging in the literature. Cardiac manifestations are frequent, including myocardial and coronary involvement, and need to be carefully identified and monitored over time.

What is Known:• Multisystem inflammatory syndrome in children (MIS-C) has been described associated with SARS-CoV-2.What is New:• Patients with MIS-C often present with fever, gastrointestinal symptoms, and shock.• Cardiac involvement is found in a high proportion of these patients, including ventricular dysfunction, coronary artery dilation or aneurysm, and arrhythmias.• Management is based on expert consensus and includes cardiac support, immunomodulatory agents, and anticoagulation.• Long-term follow-up is required due to the unclear prognosis and risk of progression of cardiac manifestation.