bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational Systems Biology in Disease Modeling and Control, Review and Perspectives
Authors: Yue Rongting , Dutta Abhishek
Published: August 2022

Omics-based approaches have become increasingly influential in identifying disease mechanismsand drug responses. Considering that diseases and drug responses are co-expressed andregulated in the relevant omics data interactions, the traditional way of grabbing omics datafrom single isolated layers cannot always obtain valuable inference. Also, drugs have adverseeffects that may impair patients, and launching new medicines for diseases is costly. To resolvethe above difficulties, systems biology is applied to predict potential molecular interactions byintegrating omics data from genomic, proteomic, transcriptional, and metabolic layers. Combinedwith known drug reactions, the resulting models improve medicines’ therapeutical performanceby re-purposing the existing drugs and combining drug molecules without off-target effects.Based on the identified computational models, drug administration control laws are designedto balance toxicity and efficacy. This review introduces biomedical applications and analysesof interactions among gene, protein and drug molecules for modeling disease mechanisms anddrug responses. The therapeutical performance can be improved by combining the predictiveand computational models with drug administration designed by control laws. The challengesare also discussed for its clinical uses in this work.
Comparative Analysis of Complete Chloroplast Genomes of Gardenia jasminoides and Contribution to the Phylogeny and Adaptive Evolution
Authors: Gong Shoufu , Miao Bailing , Dong Xiangxiang
Published: August 2022

Gardenia jasminoides, belonging to the Rubiaceae family, is widely distributed and planted in China. It has traditionally been used as an ornamental and medicinal plant in several Asian countries. The rapid development of high-throughput sequencing technology makes it feasible to obtain complete chloroplast (cp) genome sequences and will deepen our understanding of evolution of G. jasminoides. In this study, we sequenced the complete cp genomes of two botanical varieties of G. jasminoides. The complete cp genomes of both botanical varieties of G. jasminoides showed highly conserved structures and the length was 154,954 base pairs (bp) for G. jasminoides var. radicans (GJR) and 155,098 bp for G. jasminoides var. grandiflora (GJG). A total of 132 and 133 genes were identified in GJR and GJG, respectively. The cp genomes of two newly sequenced G. jasminoides were further compared with two published G. jasminoides cp genomes. Multiple repeats and simple sequence repeats (SSRs) were detected among different genotypes of G. jasminoides. The intron sequences of rps16 and rpl16 genes were slightly divergent among four genotypes of G. jasminoides. Phylogenetic analyses based on the complete cp genome sequences showed that G. jasminoides was closely associated with Fosbergia shweliensis, with Coffea as their close relative. Taken together, the complete cp genomes of GJG and GJR provided significant insights and important information that can be used to identify related species and reconstruct their phylogeny.
Presidential election polls and stock returns in Taiwan
Authors: Chen Yi-Shuan
Published: August 2022

This paper examines the impacts of 29 opinion polls from three prominent media sources on 825 firms listed on the Taiwan Stock Exchange during the 2020 Taiwan presidential election campaign. In the election, the challenger Han adopted unprecedented election tactics of asking his supporters to mislead pollsters on their voting intentions, separating the sample polls published before and after the start of this election tactic into normal and chaotic periods. This study assumes that stock markets respond positively to the increased incumbent polling leads due to the reduced probability of future changes to economic policy only for the credible normal polls. A standard event study in a 3-day event window, one day before and after the event day, is employed to analyze the short polling effects on stock returns during the sample period. The estimation window is 120 days. The results indicate that market returns are positively associated with the changes in the incumbent’s lead only for the television’s normal polls, and markets react more strongly to decreased polling leads than to increased polling leads for television polls, as presumed by the uncertain information hypothesis. Analysis of the impact of polling during the chaotic period on investor sentiment indicates that the market has positive reactions to both positive and negative polling changes, suggesting the tactic creates confusion in the market. This paper concludes that markets may react differently to opinion polls depending on their source and candidates’ election tactics.
BİR ÂDEMİYET ANLATISI OLARAK VESÎLETÜ’N-NECÂT
Authors: AK Murat
Published: August 2022

Osmanlı dönemi Türk edebiyatında Hz. Peygamber’i konu edinen birçok dînî-edebî tür ortaya çıkmıştır. Hz. Peygamber’in doğumunun, mi’râcının ve ahlâkî özelliklerinin anlatıldığı mevlid türü bu dinî-edebî türler içinde birçok müstakil örneği bulunması açısından oldukça önemlidir. Bu türün Türk edebiyatında en meşhur örneği ise Süleyman Çelebi tarafından XV. yüzyılın hemen başında telif edilen Vesîletü’n-Necât isimli mesnevîdir. Vesîletü’n-Necât, sosyal ve siyasal işlevi açısından ehl-i sünnetin tasavvufî yorumuyla Osmanlı topraklarında itikâdî ve siyâsî birlikteliği sağlamaya çalışan bir metindir. Bu hususiyetiyle Vesîletü’n-Necât Osmanlı topraklarında yaşayan insanlar için istikamet tayin eden öncü ve kurucu metin şeklinde tavsif edilmiştir. Bununla birlikte muhtevâsı itibariyle tasavvufî düşünce zemininde telif edilen eser, Hz. Peygamber şahsında kaleme alınmış bir âdemiyet anlatısı olarak karşımıza çıkar. Vesîletü’n-Necât’ın zeminini oluşturan tasavvufî düşünce sisteminde Hz. Peygamber, yegâne insân-ı kâmil olarak tasavvur edilir. Hz. Peygamber, insan nev’inin en mükemmel varoluşunu temsil eden Hz. İnsan’dır ve maddî ve manevî şahsıyla bütün bir âdemiyeti temsil etmektedir. Bu yönüyle Vesîletü’n-Necât’ı ademiyetin Hz. Peygamber şahsında anlatıldığı bir meta-anlatı olarak ele almak mümkündür. Vesîletü’n-Necât’ı bugün Anadolu toplumu içinde hâlâ popüler kılan önemli sebeplerden birisi, sahip olduğu dilsel ve sanatsal özellikler kadar eserin Hz. Peygamber’in şahsında evrensel bir âdemiyet anlatısı hüviyetine sahip olması, yaratılışa ve varoluşa ilişkin sorulara verdiği cevaplarla âdemiyeti anlamlandırmasıdır.
FİRDEVSÎ-İ TAVÎL’İN TECNÎSÂT-I SÜLEYMÂN U BELKÎS-NÂME ADLI ESERİ VE CİNAS SANATI
Authors: ÇELİK Recep , SUCU KÖROĞLU Nurgül
Published: August 2022

15. yüzyıl şair ve nasiri Firdevsî-i Tavîl tarafından kaleme alınan Tecnîsât-ı Süleymân u Belkîs-nâme; Hz. Süleyman’ın muhtelif kıssalarının ve Sebe melikesi Belkıs’ın hayat hikâyesinin işlendiği, yaklaşık 20.000 beyitten müteşekkil, oldukça hacimli bir mesnevidir. Bizzat Firdevsî tarafından diğer eserlerinde bahsedilmesine ve çeşitli kaynaklarda bu bilgilerin tekrar edilmesine rağmen, yakın zamana kadar bu esere ulaşılamamıştır. Belkîs-nâme, bizim de dâhil olduğumuz bir ekip tarafından gün yüzüne çıkarılmış olup eserin ilim âlemine tam metin olarak sunulabilmesine yönelik çalışmalar hâlen devam etmektedir. Eserin şu anda elimizde, Uppsala ve Gotha nüshaları olmak üzere iki nüshası mevcuttur. Baştan sona cinas sanatı ile kaleme alınmış olması ve özellikle Sebe melikesi Belkıs’ın hayatı gibi, edebiyatımızda daha önce yeteri kadar üzerinde durulmamış bir konuyu detaylı bir şekilde işlemesi, eserin kıymetini artıran özelliklerdir. Bu makalede; öncelikle, mevcut nüshalarından yola çıkılarak eser tanıtılmaya çalışılmış, daha sonra, konuyla ilgili temel kaynaklar da göz önünde bulundurularak cinas sanatına dair detaylı ve yeni bir tasnif yapılmaya çalışılmış, son olarak da bu tasnifin bütün alt maddeleri Belkîs-nâme’den seçilen uygun beyitlerle örneklendirilmiştir.
ETNİK KİMLİĞİN DİL VE DİN TEMELİNDE İNŞASI: GAGAUZ ETNİSİTESİNE YÖNELİK BİR ANALİZ
Authors: SAYGILI Rukiye
Published: August 2022

Mukim olunan çok dinli-dilli coğrafya, yaşanan tarihsel gelişmeler, farklı devlet arasındaki siyasi nüfuz mücadeleleri ve tek tip olmayan kültürel ayırt ediciler, etnik kimlikleri tartışmalı hale getirmektedir. Söz konusu kimliklerden birisi de Gagauzlara aittir. Ortodoks toplulukların aksine Türkçeyi etnik dil olarak kullanmaları ve genelde Müslüman olan Türkî etnik topluluklardan farklı olarak Hristiyanlığı benimsemeleri, yüzyıllarca birçok devletin himayesinde kalan bu etnik topluluğu bilimsel açıdan dikkat çekici hale getirmektedir. Bu bağlamda Gagauz kimliğine yönelik çıkarımlar, nihai olarak kültürel aktarımı gerçekleştiren, etnik kimliği inşa eden ve etnik sürekliliği sağlayan dil ve din vasıtasıyla ortaya konmaktadır. Birincil ile ikincil kaynaklara dayanan bu nitel çalışma, Gagauzların etnik kimliğinin en temel nişaneleri olan Gagauz etnogenezi ve etnonimini dil ve din özelinde incelemeyi amaçlamaktadır. Gagauz etnik kimliğine yönelik daha tutarlı bir çalışma ortaya koyma gayretine bağlı olarak diğer etnik çalışmalarda da önemli yer tutan etnik tarih, etnik anayurt ve etnik kültür gibi etnisitenin boyutları da bu çalışmaya araştırma nesnesi olarak dâhil edilmiştir.
SOVYETLERİN İSLAM POLİTİKASI VE ORTA ASYA’DA DİNİ İDARE (1943-1990) ZHOLDASSULY, Talgat (2022), Sovyetlerin İslam Politikası ve Orta Asya’da Dini İdare (1943-1990) Leiden: Sota Yayınları ISBN:978-90-6921-058-2, 223 s.
Authors: BENHÜR Çağatay
Published: August 2022

2007 yılında Korkut Ata Kızılorda Devlet Üniversitesi Tarih ve Hukuk Fakültesinde Tarih bölümünden mezun olan Talgat Zholdassuly, daha sonra İçişleri Halk Komiserliği’nin Kuruluşu ve Faaliyeti (1934-1953) (Sovyet Dönemi) isimli çalışmasıyla 2008 yılında yüksek lisans tezini başarıyla savunmuştur. 2021 yılında Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Tarih Anabilim Dalında, Orta Asya ve Kazakistan Müslümanları Diniye Nezareti (1943-1990) isimli teziyle doktor unvanı alan yazarımız, bu tezini Sovyetlerin İslam Politikası ve Orta Asya’da Dini İdare (1943-1990) adıyla kitap haline getirerek 2022 yılında okurlara sunmuştur.
TATAR DİLİNİN AÇIKLAMALI SÖZLÜĞÜ Tatarstan Respublikası Fenner Akademiyasĕ Ğ. İbrahimov Tĕl, Edebiyat hem Senğat İnstitutı. (2015-2021). Tatar Tĕlĕnĕñ Añlatmalı Süzlĕgĕ (C I-VI). Kazan: TEhSİ, ISBN: 978-5-93091-189-3.
Authors: EKİCİ Fatih
Published: August 2022

Türk dilinin kuzeybatı grubu içerisinde yer alan Tatar Türkçesi, köklü bir sözlükçülük (leksikografi) geleneğine sahiptir. 1552 yılında Kazan’ın işgali ile birlikte Tatarların Rus egemenliği altına girmesi, beraberinde bu iki milletin birbirinin dilini öğrenip anlaması gerekliliğini ortaya çıkarmıştır. XVI. yüzyıldan itibaren ise dil öğretimi maksadıyla çeşitli sözlüklerin hazırlanmaya başladığı görülmektedir1. Tatarcanın ilk sözlük örneklerini Rusça-Tatarca iki dilli sözlükler oluşturmaktadır2. İki dil arasındaki bu ilişki, yöntem açısından birbirlerinin sözlükçülük geleneğine de etki etmiş, iki dilli sözlükler dışında, çıkarılan tek dilli sözlüklerde de bu etkinin izleri sürdürülmüştür. Tek dilli sözlüklerin esasını ise o dilin genel mahiyetli açıklamalı sözlükleri oluşturmaktadır.
Nonlinear dynamic behavior analysis of bridge pier impacted by a moving barge
Authors: Xie Chunhui , Wang Yu , Zhu Huaxin , Wang Jie , Cui Li , Cao Maosen
Published: August 2022

The contradiction between ships and bridges is becoming increasingly prominent, and ship-bridge collision accidents occur frequently. However, the existing researches focus on the impact force, the bridge will be simplified to a single pier, but the single pier collision model cannot accurately reflect the dynamic behaviors and damage evolution process of collision. In order to solve this problem, a refined barge-whole bridge collision finite element model is established. This model can be used to analyze the dynamic characteristics of barge and whole bridge collision. According to finite element results, the impact force can be divided into four phases: (1) Linear elastic phase, (2) Buckling unstable phase, (3) Plastic deformation phase and (4) Unloading phase. The impact velocity and barge mass change the initial kinetic energy of the barge, which is positively correlated with the peak impact force and the duration of the impact force. Compared with the barge-single pier collision model, the barge-whole bridge collision model is more systematic and comprehensive in reflecting the dynamic behavior of collision. In this paper, the research of barge-bridge collision provides a scientific basic theoretical basis for the design of anti-collision facilities, the proposal of post-collision damage assessment techniques and the development of bridge post-collision warning system.
Study on bearing mechanical and thermal characteristic evolvement rules affected by higher ambient temperature
Authors: Yun Xianghe , Xie Fangjie , Han Qingkai
Published: August 2022

In this paper, the bearing mechanical characteristics and thermal characteristics as it is running under constant speed (2400 r/min) and constant temperature (100 ℃) adopting bearing mechanical-thermal coupling model built on the basis of quasi-statics and elastohydrodynamic lubrication theory are discussed. Among which, the contact deformation between ball and inner/outer ring has same evolution law, besides, the same as the amplitude. Whose curve shape changes in the form of “circular-oblique D”, its amplitude rearches minimum value at 10thd3h between the location of 120° and 270°. The curve shapes belonging to contact angular between ball and inner/outer ring are similar to “circular”. There is opposite trend of them within the range of 90-300°. The amplitude of contact angular between ball and outer ring is the minimum at 10thd3h and 11thd1h. At the same time, the amplitude of that between ball and inner ring is the maximum. The evolution rules of contact stiffness between ball and inner/outer ring are generally consistent, which are similar to “crab”. But the amplitude of that between ball and outer ring is dominant. The maximum value of them occurs at 10thd3 and 11thd1h. The evolvement tendency of node temperatures maintains stable. Thereinto, the temperature of inner ring equals to that of contact location between ball and inner ring, which is the maximum value. It is obvious that ME, MD, MS, MCB, MCR and MOil devote themselves to heat production, the contribution rates of ME, MS, MCB and MCR are 100 %, the contribution rate of MD ranges from 52.6 % to 65.2 %. However, the amplitudes of friction moments have the opposite trend compared to “heat contribution factor”. The expansion amount owing to heat production is dominant in displacement variation and the effect of clearance on displacement can be ignored, whose evolution rules are contrary. The evolution rules of oil film thickness and oil film stiffness between ball and inner/outer ring are alike. Among which, the oil film thickness between ball and outer ring is dominant, its maximum value emerges at 10thd3h. The curve shapes of oil film stiffness between ball and outer/inner ring are oblique “D”, their amplitudes reach the maximum at 11thd1h-11thd3h.
Application of A* algorithm in intelligent vehicle path planning
Authors: Wang Ruili , Lu Zhizhan , Jin Yunfeng , Liang Chao
Published: August 2022

Path planning is one of the important directions in the field of intelligent vehicles research. Traditional path planning algorithms generally use Dijkstra algorithm, Breadth-First-Search (BFS) algorithm and A* algorithm. Dijkstra algorithm is a search-based algorithm, which can search to an optimal path, but the disadvantage is too many expansion nodes, which leads to insufficient search efficiency. BFS algorithm is a heuristic search algorithm, which reduces the disadvantage of too many expansion nodes and improves the search efficiency by heuristic function. A* algorithm is a heuristic search algorithm that combines Dijkstra’s algorithm and BFS algorithm, which has higher search efficiency and can search to an optimal path at the same time, but it is still lacking in the search mode and smoothness of the planned route. This paper first introduces the general path planning algorithm, then introduces and analyzes the A* algorithm, and proposes improvement measures for its shortcomings; finally, the executability and effectiveness of the improved algorithm are tested using simulation, and compared with the traditional A* algorithm, and the results show that the improved A* algorithm has good effect on path planning of intelligent vehicles.
La huella de carbono equivalente de algunos platos típicos colombianos
Authors: Salazar-Ceballos Alexander , Alvarez-Miño Lidice
Published: August 2022

Una dieta saludable y sostenible es aquella que reduce el impacto sobre el medio ambiente, a su vez, promueve la salud. Desde la salud pública la obesidad, diabetes, hipertensión y enfermedades coronarias conocidas como enfermedades no transmisibles (ENT) relacionadas con la dieta, y la adopción de una dieta saludable y sostenible puede contribuir a su prevención. Se realizó un estudio que tuvo como objetivo describir el impacto ambiental de varios platos típicos de las diferentes regiones geográficas de Colombia considerando su receta original inicialmente y luego eliminando las carnes rojas y carnes procesadas. El estudio calculó el total de CO2-eq/kg del plato típico a partir de la base de datos de Food Impacts on the Environment for Linking to Diets que permite conocer el CO2-eq/kg de cada alimento. Los resultados mostraron que el plato típico que presentó el mayor impacto ambiental fue el friche de chivo con 21,719 CO2-eq/kg. Al eliminar las carnes rojas y las carnes procesadas de los platos típicos, se obtuvieron valores menores de 1 CO2-eq/kg, excepto la bandeja paisa que tuvo un valor final de 2,035 CO2-eq/kg. Se concluye que adoptar una dieta saludable y sostenible disminuiría la mortalidad por enfermedades no transmisibles.
Percepción de dieta, hábitos de salud, agencia personal durante la COVID-19
Authors: Jiménez-Martínez Martha Cecilia , Latorre-Velásquez Diana Carolina , Ramírez-Roncancio Nancy Lizeth , González-Valencia Guadalupe
Published: August 2022

Analizar el efecto de hábitos alimentarios, situación emocional y agencia personal de la actividad física sobre la percepción de dieta y tiempo de actividad física, de universitarios colombianos en condiciones de confinamiento por la COVID-19. Investigación exploratoria de tipo correlacional con alcance explicativo en su nivel de conocimiento. Se aplicó de forma voluntaria un cuestionario en plataforma Google a 389 estudiantes. El modelo estructural explica el 38% de la variabilidad de la percepción de dieta de los estudiantes y 53% de la variabilidad del tiempo dedicado a la AF. Posee bondad de ajuste tanto estadístico, χ² = 84 (47 gl), p = 0,09, como práctico, IBBAN = 96, IBBANN = 99, IAC = 0,99 y RMSEA = 0,02 (0,00, 0,04), por lo que se puede afirmar que este modelo inclusivo tiene el mismo poder de explicación que el modelo saturado, que relaciona todas las variables entre sí. Se evidencia un efecto directo entre las variables hábitos alimenticios, intencionalidad y la percepción que los estudiantes universitarios tienen de su dieta. Así mismo, se observa que, las variables antes mencionadas contribuyen a que aumente el tiempo en minutos de AF.
Factores de riesgo y protección en los programas de prevención del consumo de sustancias psicoactivas
Authors: Trillos-Cuello Daniela , Cogollo-Milanés Zuleima
Published: August 2022

En la adolescencia se presentan una serie de cambios tanto físicos como del pensamiento y se pueden generar riesgo de consumo de sustancias psicoactivas, por ello surgen diferentes estrategias de promoción y prevención a través de los programas de intervención. El objetivo de este trabajo es revisar la evidencia disponible sobre factores de riego y protección en la prevención del consumo de sustancias psicoactivas. En esta revisión sistemática de artículos publicados en inglés, español y portugués de bases de datos como: Pubmed/Medline, Dialnet, Scopus, Redib, Lilacs, Google Scholar, Science Direct y Scielo, se incluyó estudios cuantitativos como: ensayos clínicos, estudios de cohorte, casos y controles, estudios descriptivos transversales y estudios mixtos, en adolescentes. La estrategia de búsqueda se realizó mediante las siguientes palabras “Factores De Riesgo” “Factores Protectores” “Trastornos Relacionados Con Sustancias” “Servicios Preventivos De Salud”, y los operadores booleanos AND y OR, se diagramó en el flujograma (PRISMA). Finalmente se encontró que, la mayoría de los estudios contemplaron factores personales, seguido de los factores familiares y en menor cantidad los factores de riesgo sociales.
Síndrome de lisis tumoral espontáneo en seminoma no gonadal retroperitoneal: reporte de caso
Authors: Vergara-Serpa Oscar , Dulce-Muñoz Jaime , Jayk-Bernal Angélica , Quintero-Villarreal Agamenón , León-Díaz María , Atilano-Vellojin Luis , Vergara-Vergara María , Echeverri-Gonzalez Cristian , Serrano-Valencia Sandra , Mestra-Martínez Jayder
Published: August 2022

El síndrome de lisis tumoral es una emergencia oncológica causada por destrucción de la célula tumoral, de forma espontánea o secundaria a la quimioterapia, que libera el contenido intracelular al torrente sanguíneo y produce hiperuricemia, hiperfosfatemia, hipocalcemia e hiperkalemia. Para su diagnóstico se debe tener un alto grado de sospecha y aplicar los criterios de Cairo-Bishop y Howard. Se presenta caso de un paciente de 35 años de edad, con antecedente de seminoma no gonadal retroperitoneal estadio IIC. Ingresó remitido desde consulta externa por intolerancia a la vía oral, deshidratación y parestesias a nivel de miembros inferiores, hiperkalemia, hipocalcemia e hiperuricemia, además de elevación de creatinina sérica. Se consideró diagnóstico de síndrome de lisis tumoral, y se trató con fluidoterapia agresiva a dosis de 2-3 L/m2/día de solución salina normal. También se indicó rasburicasa y se corrigieron las alteraciones electrolíticas. Una vez se tuvo la función renal por encima de 60 mL/min/1,73 m3, se inició tratamiento citorreductor con cisplatino, etopósido y bleomicina. Se concluye la importancia de tener sospecha diagnóstica en pacientes oncológicos, incluso en neoplasias de bajo riesgo. Asimismo, se resalta que, en las revisiones de la literatura, su incidencia está sujeta a reportes de caso.
Evaluations of FDA-approved Drugs Targeting 3CLP of SARS-CoV-2 Employing a Repurposing Strategy
Authors: Ahmad Syed Sayeed , Khalid Mohammad
Published: August 2022

Background:

The SARS-CoV-2 coronavirus (COVID-19) has raised innumerable global
concerns, and few effective treatment strategies have yet been permitted by the FDA to lighten
the disease burden. SARS-CoV-2 3C-like proteinase (3CLP) is a crucial protease and plays a key
role in the viral life cycle, as it controls replication, and thus, it is viewed as a target for drug
design.

Methods:

In this study, we performed structure-based virtual screening of FDA drugs approved
during 2015-2019 (a total of 220 drugs) for interaction with the active site of 3CLP (PDB ID
6LU7) using AutoDock 4.2. We report the top ten drugs that outperform the reported drugs against
3CLP (Elbasvir and Nelfinavir), particularly Cefiderocol, having the highest affinity among the
compounds tested, with a binding energy of -9.97 kcal/mol. H-bond (LYS102:HZ2-ligand: O49),
hydrophobic (ligand-VAL104), and electrostatic (LYS102:NZ-ligand: O50) interactions were observed
in the cefiderocol-3CLP complex. The docked complex was subjected to a 50 ns molecular
dynamics study to check its stability, and stable RMSD and RMSF graphs were observed.

Results:

Accordingly, we suggest cefiderocol might be effective against SARS-CoV-2 and urge
that experimental validation be performed to determine the antiviral efficacy of cefiderocol against
SARS-CoV-2.

Discussion:

Along with these, cefiderocol is effective for treating respiratory tract pathogens and a
wide range of gram-negative bacteria for whom there are limited therapeutic alternatives

Conclusion:

This article aimed to explore the FDA-approved drugs as a repurposing study against
3CLP for COVID-19 management.
Sildenafil Inhibits the Growth and Epithelial-to-mesenchymal Transition
of Cervical Cancer via the TGF-β1/Smad2/3 Pathway
Authors: Ke Xiao-Ping , Liu Ping , Pei Jing-Jing , Li Li , Li Jing-Wei
Published: August 2022

Aims:

To explore new potential treatment for cervical cancer.

Background:

Cervical cancer is the second most common cancer in women, causing >250,000 deaths worldwide. Patients with cervical cancer are mainly treated with platinum compounds, which often cause severe toxic reactions. Furthermore, the long-term use of platinum compounds can reduce the sensitivity of cancer cells to chemotherapy and increase the drug resistance of cervical cancer. Therefore, exploring new treatment options is meaningful for cervical cancer.
Objective: The present study was to investigate the effect of sildenafil on the growth and epithelial-to-mesenchymal transition (EMT) of cervical cancer.

Objective:

Objective: The present study was to investigate the effect of sildenafil on the growth and epithelial-to-mesenchymal transition (EMT) of cervical cancer.

Methods:

HeLa and SiHa cells were treated with sildenafil for different durations. Cell viability, clonogenicity, wound healing and Transwell assays were performed. The levels of transforming growth factor-β1 (TGF-β1), transforming growth factor-β type I receptor (TβRI), phosphorylated (p-)Smad2 and p-Smad3 in cervical cancer samples were measured. TGF-β1, Smad2 or Smad3 were overexpressed in HeLa cells, and we measured the expression of EMT marker proteins and the changes in cell viability, colony formation, etc. Finally, HeLa cells were used to establish a nude mouse xenograft model with sildenafil treatment. The survival rate of mice and the tumor size were recorded.

Results:

Results: High concentrations of sildenafil (1.0-2.0 μM) reduced cell viability and the number of HeLa and SiHa colonies and the invasion/migration ability of HeLa and SiHa cells in a dose- and time-dependent manner. The expression of TGF-β1, TβRI, p-Smad2 and p-Smad3 was significantly enhanced in cervical cancer samples and cervical cancer cell lines. Sildenafil inhibited the expression of TGF-β1-induced EMT marker proteins (Snail, vimentin, Twist, E-cadherin and N-cadherin) and p-Smad2/3 in HeLa cells. Overexpression of TGF-β1, Smad2 and Smad3 reversed the effect of sildenafil on EMT, viability, colony formation, migration and invasion ability of HeLa cells. In the in vivo study, sildenafil significantly increased mouse survival rates and suppressed xenograft growth.

Conclusion:

Sildenafil inhibits the proliferation, invasion ability and EMT of human cervical cancer cells by regulating the TGF-β1/Smad2/3 pathway.
Characteristic Hallmarks of Aging and the Impact on Carcinogenesis
Authors: Fiore Marco , Terracina Sergio , Ferraguti Giampiero , Petrella Carla , Bruno Sabina Maria , Blaconà Giovanna , Di Certo Maria Grazia , Minni Antonio , Greco Antonio , Musacchio Angela , Ralli Massimo , Tarani Luigi , Ceccanti Mauro , Polimeni Antonella , Triaca Viviana
Published: August 2022

Evidence shows that there is a synergistic, bidirectional association between cancer and aging with many shared traits. Age itself is a risk factor for the onset of most cancers while evidence suggests that cancer and its treatments might accelerate aging by causing genotoxic and cytotoxic insults. Aging has been associated with a series of alterations that can be linked to cancer: i) genomic instability caused by DNA damage or epigenetic alterations coupled with repair errors, which lead to progressive accumulation of mutations; ii) telomere attrition with possible impairment of telomerase, shelterin complex, or the trimeric complex (Cdc13, Stn1 and Ten1 – CST) activities associated with abnormalities in DNA replication and repair; iii) altered proteostasis especially when leading to an augmented proteasome, chaperon and autophagy-lysosome activity; iv) mitochondrial dysfunction causing oxidative stress; v) cellular senescence; vi) stem cells exhaustion, intercellular altered communication and deregulated nutrient sensing which are associated with microenvironmental modifications which may facilitate the subsequential role of cancer stem cells. Nowadays anti-growth factor agents and epigenetic therapies seem to assume an increasing role to fight aging-related diseases, especially cancer. This report aims to discuss the impact of age on cancer growth.
Freshwater Microalgae as Promising Food Sources: Nutritional and Functional Properties
Authors: Prihanto Asep A. , Jatmiko Yoga D. , Nurdiani Rahmi , Miftachurrochmah Anis , Wakayama Mamoru
Published: August 2022

A number of researchers have predicted that the current food crisis is predicted to worsen in 2050. The prediction of this crisis is aligned with climate change causing increases in some basic foodstuff prices. Therefore, everyone should prepare to consume alternative foods at an early stage. Alternative foods have been widely developed, one of which involves microalgae. However, the type of microalgae produced by some countries on a large scale consists of only oceanic/seawater microalgae. This will have an impact on and hinder development in countries that do not have these resources. Therefore, it is necessary to explore the use of microalgae derived from freshwater. Unfortunately, freshwater microalgae are still rarely investigated for use as alternative foods. However, there is considerable potential to utilize freshwater microalgae, and these algae are very abundant and diverse. In terms of nutritional properties, compared to oceanic / seawater microalgae, freshwater microalgae contain nearly the same protein and amino acids, lipids and fatty acids, carbohydrates, and vitamins. There are even more species whose composition is similar to those currently consumed foods, such as beef, chicken, beans, eggs, and corn. In addition to dietary properties, freshwater microalgae also have functional properties, due to the presence of pigments, sterols, fatty acids, and polyphenols. Given the potential of freshwater microalgae, these aquatic resources need to be developed for potential use as future food resources.
Enhancing the Cyanide Sensing Performance of the CuBi2O4 Nanoflakes
by Polyaniline
Authors: Pei Lizhai , Zhang Yong , Zhuang Lihong , Cai Zhengyu
Published: August 2022

Background:

Cyanide (CN-) belongs to dangerous anion pollutants owing to its toxicity at low level. The development of an efficient method for the cyanide detection in aqueous solution is of tremendous importance for protecting the environment and human health. Polyaniline/CuBi2O4 composite modified electrode possesses good electro-catalytic activity towards cyanide.

Objective:

The aim is to synthesize polyaniline/CuBi2O4 nanoflakes by a facile hydrothermal route using the CuBi2O4 nanoflakes and polyaniline as the raw materials, and research the electro-catalytic activity towards cyanide of the composite nanoflakes.

Methods:

Polyaniline/CuBi2O4 nanoflakes were synthesized by a facile hydrothermal route using the CuBi2O4 nanoflakes and polyaniline as the raw materials. The structure, morphology, chemical bonding and electro-catalytic activity towards cyanide of the composite nanoflakes were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and electrochemical measurements.

Results:

The obtained composite nanoflakes are composed of tetragonal CuBi2O4 phase. Amorphous polyaniline nanoscale particles with the size of about 50 nm attach to the surface of the CuBi2O4 nanoflakes. The nanoflakes modified glassy carbon electrodes (GCEs) were used for the determination of cyanide. A pair of quasi-reversible cyclic voltammetry (CV) peaks are located at +0.25 V and +0.33 V, respectively at the polyaniline/CuBi2O4 nanoflakes modified GCE. The linear range and detection limit are 0.01-2 mM, 3.1 μM and 0.001-2 mM, 0.39 μM for CuBi2O4 nanoflakes modified GCE, and polyaniline/CuBi2O4 nanoflakes modified GCE, respectively.

Conclusion:

Polyaniline/CuBi2O4 nanoflakes modified GCE shows good reproducibility and stability for cyanide detection. The electro-catalytic activity towards cyanide of the CuBi2O4 nanoflakes modified GCE can be greatly enhanced by the polyaniline.
Love in Comparative Religious Studies (Islam and Other Faiths)
Authors:   Dagestan State Medical University, Kafarov Telman Emiralievich
Published: August 2022

The article is devoted to the issue of love, which lacks interpretation in Islam, since the lat-ter belongs to the masculine worldview with the ritual and collective principle dominating, while the personal-subjective, rational and motivational aspects remain less expressed and investigated. The main reason for this is Islam’s fixation on slavish submission present both in the etymology of the word “Islam” and in its content, which allegedly leaves little room for love in all its manifestations. The article shows that submission in the religious sense means the highest degree of trust, love and human freedom, through which various forms of human dependence are overcome. It is proved that the context of love is in the basis of all religions of revelation and Islam is no exception. It is present in all versions of Islam; the Qur'an and the Sunna contain unambiguous imperatives regarding love for God and for one’s neighbours.The greatest importance is attached to love in Sufism, which is called the “religion of love”. The author grounds the necessary to distinguish between confessional and existential dimensions of love: according to the former, only love for God can be true and complete, while all human dimensions of love are derived from it. However, this statement that is true in the confessional dimension, contradicts the logic of modern cultural pluralism, since it denies the right to real, true love to people of a secular, non-religious worldview and does not fit into the framework of the constitutional norm of the freedom of conscience. The author also attempts to ap-ply the ancient concept of agape love to the Islamic worldview.
Algorithm for numerical calculation of nonlinear lenticular membrane-pneumatic systems by iterative method of parameter increments taking into account the aftereffect of air pressure
Authors: Kim A. Yu. , Amoyan M. F. , Khapilin V. E.
Published: August 2022

Objective. The purpose of this study is to create a static calculation algorithm to determine the maximum bearing capacity of a lenticular membrane-pneumatic system for covering large spans under the action of external force loads.

Method. A numerical study of a large-span membranepneumatic structure was carried out by the step method of incrementing parameters using the finite element method and the Euler-Cauchy numerical procedure of the third order of accuracy at the step.

Result. The authors have developed a technique for computer static calculation of geometrically and physically nonlinear lenticular membrane-pneumatic systems of coatings for large span structures by the iterative method of parameter increments with the phased application of the finite element method in the form of the displacement method, the universal equation of gas state and the improved Euler-Cauchy numerical procedure of the third order of accuracy.

Conclusion. Ignoring the aftereffect in the calculations means the imbalance of the system due to unbalanced pneumatic forces calculated with an error of 11.2% and affecting, as the calculations showed, in the amount of approximately 7% percent on the increment of excess air pressure in the lens.
Accumulation of irreversible deformation of soils as a result of repeated loading
Authors: Kondrashin K. G. , Petrov R. A. , Raktovich N. A.
Published: August 2022

Objective. The purpose of the study is to establish the patterns of accumulation of irreversible soil deformations from repeated loading.

Method. When loading soils, the balance between external and internal forces is established gradually over a more or less long time. Therefore, with a single application of a cyclic load, such an equilibrium can be achieved only in a relatively long time.

Result. An approximate method is proposed for calculating the magnitude of the deformation developed as a result of the action of a cyclic load. The cases are determined when it is necessary to take into account the viscous component of deformation and when the latter can be neglected. It has been established that when determining the deformation of soils that has developed during a single application of such cyclic loads that are characteristic of the process of their compaction by machines, in all cases, except for rolling them with rollers on pneumatic tires, the viscous component of deformation can be ignored.

Conclusion. In a relatively short time of the load, the state of equilibrium can be achieved only in the process of soil deformation by repeated loading. With an increase in the number of loading repetitions, the soil gradually hardens, and the deformation decreases. This occurs both due to the irreversible and reversible parts of the deformation. Consequently, the soil deformation modulus increases from cycle to cycle.
Calorimetric stand for research of processes in the refrigeration unit
Authors: Kudrov Yu. V. , Sumzina L. V. , Maksimov A. V. , Filimonov S. L.
Published: August 2022

Objective. The aim of the work is to develop a calorimetric stand that allows simulating the operation of an energy-efficient two-evaporator refrigeration unit of a household refrigerator or freezer.

Method. In the course of the work, a calorimetric setup is described that allows conducting experimental studies to determine the cooling capacity and energy efficiency of a modernized refrigeration unit of a household refrigerator.

Result. Currently, new resource-saving circuit solutions for household refrigeration equipment have been developed. The developed solutions make it possible to increase the efficiency of the refrigeration unit, as well as to reduce its energy consumption. Theoretical calculations confirming these indicators have been carried out. To confirm the calculated values, automated experimental studies are required to determine the parameters of the refrigeration unit. The paper proposes a description of an automated calorimetric stand that allows simulating the operation of an energy-efficient dual-evaporator refrigeration unit of a household refrigerator or freezer.

Conclusion. The designed calorimetric stand will allow carrying out complex experimental studies to determine the cooling capacity of the modernized refrigeration unit when operating on various refrigerants. The experimental setup also makes it possible to measure the temperature and pressure during the operation of the refrigeration unit, as well as to determine the influence of various factors on its characteristics.
Recuperación de poblaciones de tortuga verde y sus interacciones con la duna costera como línea base para una restauración ecológica integral
Authors: Guzmán-Hernández Vicente , Del Monte-Luna Pablo , López-Castro Melania C. , Uribe-Martínez Abigail , Huerta-Rodríguez Patricia , Gallegos-Fernández Sandra A. , Azanza-Ricardo Julia , Martínez-Portugal Rosa C. , Barragán-Zepeda Ana K. , Quintana-Pali Guadalupe P. , Martín-Viaña Yanet F. , Gómez-Ruíz Pilar A. , Acosta-Sánchez Héctor H. , López-Hernández Martha , Castañeda-Ramírez D. Gerardo , Ortíz Antonio , Cuevas Eduardo
Published: August 2022

Antecedentes y Objetivos: La restauración ecológica se ha centrado en los componentes físicos y vegetales de los ecosistemas, y ha dejado de lado a la fauna silvestre y sus interacciones. Chelonia mydas es un macroherbívoro en peligro de extinción que anida en playas de México y Cuba, e influye en la vegetación costera con aportaciones de materia orgánica. Los objetivos de este estudio fueron analizar su recuperación poblacional, un índice del verdor de la vegetación de duna, así como la cantidad de materia orgánica estimada de sus nidadas antes y después de la implementación de una Norma Oficial Mexicana.
Métodos: Se analizaron datos de entre dos y tres décadas de monitoreo biológico en 16 playas de anidación de Chelonia mydas; a partir de ellos se realizaron tres niveles de análisis de indicadores demográficos, la aportación de materia orgánica de las tortugas en la playa y el vigor vegetal a partir de sensores remotos, además de aplicar los estadísticos pertinentes.
Resultados clave: Hubo un crecimiento exponencial del número de anidaciones de tortuga verde (entre 12 y 14% anual), asociado con pulsos de reclutamiento poblacional en los años 2000 y 2008. El aporte de materia orgánica a la playa fue significativamente mayor después de un cambio en la estrategia para manejo de las nidadas en México, y se detectó un incremento en el verdor de la vegetación de duna en zonas de anidación alta de Chelonia mydas.
Conclusiones: El incremento de las poblaciones de tortuga verde lleva a reflexionar acerca de las implicaciones que tiene la recuperación de especies de fauna sobre otras comunidades en los ecosistemas que habitan, lo que demanda el análisis de los paradigmas actuales y la adaptación de estrategias que atiendan sus necesidades de manejo, procurando las condiciones de integridad ecológica de sus hábitats.
Modeling CO2 and N2 Permeation through Mixed Matrix Membranes Containing Oxygenated Carbon Nanotubes Dispersed in Polysulfone
Authors:   Department of Chemical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Brazil, Barbosa Thales Almeida , Flores Marcelo Costa ,   Department of Chemical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Brazil, Figueiredo Katia Cecília de Souza ,   Department of Chemical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Brazil
Published: August 2022

Mixed matrix membranes (MMMs) consist of a polymeric phase and a dispersed solid filler such as zeolites or carbon nanotubes. We prepared symmetric and asymmetric polysulfone-based MMMs containing functionalized multi-walled carbon nanotubes (MWNT-O) for CO2/N2 separation. Maxwell’s model was used to predict the permeabilities of MMMs. The permeability achieved using the model exhibited a good fit of the model in symmetric MMMs, especially for CO2. This can be potentially attributed to the high affinity of the system toward the polymer matrix. The permeability recorded using Maxwell’s model could not reflect the properties of the asymmetric membranes, and this could be attributed to the generation of voids around the fillers or defects present on the surface of the skin. Finally, a mathematical fit was proposed to improve prediction accuracy for both the MMM systems.
Compuestos fenólicos totales y actividad antioxidante de la fermentación en estado sólido de bagazo de manzana (Malus domestica Borkh., var. panochera)
Authors: Ibarra-Cantún Diego , Ramos-Cassellis María Elena , Sánchez-Arzubide Madai Gizeh , Castelán-Vega Rosalía del Carmen , Marín-Castro Marco Antonio
Published: August 2022

La agroindustria genera cantidades importantes de residuos lignocelulósicos. Estos son utilizados como sustrato en la producción de hongos del género Pleurotus, que a través de la fermentación en estado sólido (FES) producen metabolitos secundarios. El objetivo de este trabajo fue determinar la cantidad de compuestos fenólicos totales y la actividad antioxidante de extractos de metanol obtenidos de la FES en bagazo de manzana con la cepa Pleurotus ostreatus durante 28 días. La fermentación sólida se realizó en los días 0, 7, 14, 21 y 28 de los extractos de metanol. Posteriormente, se evaluaron el contenido de compuestos fenólicos totales y la actividad antioxidante por los métodos 1,1-difenil-2-picrilhidracilo (DPPH•) y 2,2’-azino-bis (3-etilbenzotiazolina)-6 sulfonato de amonio (ABTS+). Las 45 muestras fueron analizadas a través de un análisis de varianza y prueba de medias de Tukey. Los resultados mostraron la biosíntesis de compuestos fenólicos totales a partir del día 21 de la FES, con una concentración de 0,39 ± 0,07 mg equivalentes de ácido gálico/g sustrato en base seca (mg de EAG/g sustrato bs). La actividad antioxidante en ambos métodos también se manifestó en el día 21 con actividades equivalentes, de 342,10 ± 1,08 mg/mL para DPPH y 323,02 mg/mL en ABTS. En consecuencia, los compuestos fenólicos extraídos de la FES del residuo de manzana con la cepa P. ostreatus pueden considerarse como una alternativa de valorización de un subproducto que actualmente es considerado como un desecho agroindustrial.
HPV Vaccine Communication Competency Scale for Medical Trainees: Interdisciplinary Development Study
Authors: Darville-Sanders Gabrielle , Reinoso Humberto , MacInnes Jann , Corluyan Emilie , Munroe Dominique , Mathis Mary W , Madden Suzie Lamarca , Hamrick Johnathan , Dickerson Lisa , Gaddis Cheryl
Published: August 2022

Background

Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the United States. High-risk HPV strains are associated with cancer of the cervix, oropharynx, anus, rectum, penis, vagina, and vulva. To combat increasing HPV-related cancers, the 9-valent HPV vaccine Gardasil was developed. Recommendation of the HPV vaccine by a health care provider has been cited as the number one factor affecting vaccine uptake among adolescents and young adults. Physician assistants, nurse practitioners, and pharmacists have been enlisted to bridge the gap.

Objective

The specific aim of this research study was to develop a reliable and valid HPV vaccine communication scale that can be used to measure the competency of primary care providers when recommending the need for vaccination to parents and patients.

Methods

Using a descriptive study, we collected data via a literature review, focus groups, and an expert panel to inform the scale domains and blueprint design. Pretesting (cognitive interviews) was used to inform item revision decisions. An item analysis was also conducted for the responses provided in the cognitive interviews. Item statistics (means and SDs), interitem correlations, and reliability were examined. Data were analyzed using SPSS (IBM Corp) software.

Results

A valid and reliable 42-item HPV vaccine communication competency scale was developed. The scale included 6 domains of interest. Scale items were moderately to strongly correlated with one another, and Cronbach α indicated good internal consistency with each scale. Scale items included were related to provider introduction or rapport (α=.796), patient respect or empathy (α=.737), provider interview or intake (α=.9), patient counseling or education (α=.935), provider communication closure (α=.896), and provider knowledge (α=.824).

Conclusions

Pharmacists, nurse practitioners, and physician assistants should be trained to be competent in HPV vaccine communication and recommendation due to their expanded roles. Interdisciplinary collaboration is important to account for the trainee’s individual differences and ensure the best health care outcomes for patients. A standardized HPV communication scale can be used to ensure effective and consistent recommendation by health care providers, thus affecting immunization rates.