bluuebunny/crossref_metadata_2025 huggingface dataset:
Stakeholder Values Inform Indigenous Peoples’ Governance and Management of a Former National Park in New Zealand
Authors: Bataille C.Y. , Luke K. , Kruger T. , Malinen S. , Allen R.B. , Whitehead A.L , Lyver P.O.’B.
Published: September 2020

The global emphasis on stakeholder engagement in protected area management has increased over the last three decades. Here we present key values of statutory and non-statutory stakeholder groups as they relate to their relationship with the former Te Urewera National Park (NP), New Zealand, which is now recognised as “a legal entity” with “all the rights,powers, duties, and liabilities of a legal person.” Non-statutory stakeholders conveyed a close, personal connection to Te Urewera NP in terms of heritage and legacy, which include both consumptive (e.g., hunting; fishing) and non-consumptive use (e.g., sight-seeing, hiking, boating). In contrast, statutory stakeholders expressed a more distant and procedural relationship with the park. Both stakeholder groups perceived the possible transfer of ownership or governance of Te Urewera NP to Tūhoe (the Indigenous Māori peoples of the Te Urewera region) favourably and expressed a desire to be engaged in the future stewardship of the NP. Stakeholders considered the fostering of relations with Tūhoe and other stakeholder groups as important to nurturing and maintaining their links with the area in future. Importantly, common interests that emerge from these relationships can increase mutual understanding between cultures and willingness to collaborate. Moreover, we posit that the legal personhood status for protected areas will be a powerful tool for reconciling pluralistic values and enable deliberative processes and flexible modes of collaboration between Indigenous peoples and non-indigenous stakeholders.
Linearized Krylov subspace Bregman iteration with nonnegativity constraint
Authors: Buccini Alessandro , Pasha Mirjeta , Reichel Lothar
Published: September 2020

Bregman-type iterative methods have received considerable attention in recent years due to their ease of implementation and the high quality of the computed solutions they deliver. However, these iterative methods may require a large number of iterations and this reduces their usefulness. This paper develops a computationally attractive linearized Bregman algorithm by projecting the problem to be solved into an appropriately chosen low-dimensional Krylov subspace. The projection reduces the computational effort required for each iteration. A variant of this solution method, in which nonnegativity of each computed iterate is imposed, also is described. Extensive numerical examples illustrate the performance of the proposed methods.
Building ‘implicit partnerships’? Financial long-term care entitlements in Europe
Authors: Costa-Font Joan , Zigante Valentina
Published: September 2020

The design of public subsidies for long-term care (LTC) programmes to support frail, elderly individuals in Europe is subject to both tight budget constraints and increasing demand preassures for care. However, what helps overcoming the constraints that modify LTC entitlements? We provide a unifying explanation of the conditions that facilitate the modification of public financial entitlements to LTC. We build on the concept of ‘implicit partnerships’, an implicit (or ‘silent’) agreement, encompassing the financial co-participation of both public funders, and families either by both allocating time and/or financial resources to caregiving. Next, we provide suggestive evidence of policy reforms modifying public entitlements in seven European countries which can be classified as either ‘implicit user partnerships’ or ‘implicit caregiver partnerships’. Finally, we show that taxpayers attitudes mirror the specific type of implicit partnership each country has adopted. Hence, we conclude that the modification of long-term care entitlements require the formation of some type of ‘implicit partnership'.
Evaluation of patients’ knowledge about oral anticoagulant medicines and use of alert cards by community pharmacists
Authors: Jani Yogini H. , Hirani Bindiya , Livingstone Carina
Published: September 2020

Background Anticoagulants continue to pose high risk of harm to patients despite the discovery of novel direct-acting oral anticoagulant agents that require less monitoring than warfarin. Objective To evaluate patients’ knowledge about their oral anticoagulants and the potential role for community pharmacists in optimising safety. Setting Community pharmacies in England. Methods An online survey-based evaluation conducted over a 5-month period to ascertain patients’ knowledge, use of anticoagulant alert cards, compliance with national monitoring requirements for warfarin, and frequency and nature of community pharmacist involvement in optimisation. Differences between patients on direct-acting oral anticoagulant agents and warfarin were assessed using Chi squared tests. Main outcome measure Patients’ knowledge and use of anticoagulant alert cards. Results A total of 1515 pharmacies participated. Of 22,624 patients, 97% knew that they were taking anticoagulants; 20% had alert cards with them at time of dispensing; 17% had no card and 10% refuted their usefulness. Patients on warfarin were more aware of interactions with over-the-counter or herbal medicines than those on direct-acting oral anticoagulant agents. Of the patients on warfarin, 82% confirmed monitoring in the previous 12 weeks in accordance with national standards, with the international normalised ratio value known for 76%. Pharmacists intervened in a fifth of the patients to issue an alert card, contact the general practitioner for a change in the prescription or due to interacting medicines. Conclusion Patients had reasonable knowledge of their anticoagulation therapy, but areas for improvement were identified. Community pharmacists are well placed to optimise the safe use of anticoagulants.
Fe based core–shell model catalysts for the reaction of CO2 with H2
Authors: Kirchner Johann , Zambrzycki Christian , Baysal Zeynep , Güttel Robert , Kureti Sven
Published: September 2020

Fe@SiO2 core–shell model catalysts were investigated for the conversion of CO2 and H2 into CH4, CO and H2O. For evaluation of the effect of core size on the catalytic activity, samples with Fe particle sizes of 4, 6 and 8 nm were prepared. Fresh and spent catalysts were thoroughly characterized by X-ray diffraction, 57Fe Mössbauer spectroscopy, transmission electron microscopy, temperature programmed hydrogenation and X-ray photoelectron spectroscopy. As a result, the yield of the major product CO as well as CH4 was increased with Fe core size. Additionally, growing Fe cores led to stronger carburization and higher amount of reactive carbide entities, which drive the CH4 formation. Finally, formation of inactive bulk carbon deposition is strongly suppressed for the core–shell catalysts in comparison to bulk iron oxide catalysts used for CO2 hydrogenation.
The impact of artificial intelligence on event experiences: a scenario technique approach
Authors: Neuhofer Barbara , Magnus Bianca , Celuch Krzysztof
Published: September 2020

Digital technologies are transforming human relations, interactions and experiences in the business landscape. Whilst a great potential of artificial intelligence (AI) in the service industries is predicted, the concrete influence of AI on customer experiences remains little understood. Drawing upon the service-dominant (SD) logic as a theoretical lens and a scenario technique approach, this study explores the impact of artificial intelligence as an operant resource on event experiences. The findings offer a conceptualisation of three distinct future scenarios for the year 2026 that map out a spectrum of experiences from value co-creation to value co-destruction of events. The paper makes a theoretical contribution in that it bridges marketing, technology and experience literature, and zooms in on AI as a non-human actor of future experience life ecosystems. A practical guideline for event planners is offered on how to implement AI across each touch point of the events ecosystem.
Adsorption of Cr(VI) ions onto goethite, activated carbon and their composite: kinetic and thermodynamic studies
Authors: Adebayo G. B. , Adegoke H. I. , Fauzeeyat Sidiq
Published: September 2020

Hexavalent chromium was adsorbed from aqueous solution with three prepared and characterized adsorbents, namely goethite (G), activated carbon (AC) and their composite (GAC). The goethite particle was synthesized using the precipitation methods, and activated carbon was prepared from the stem bark of Daniellia oliveri tree and composite in a ratio of 1:5 goethite–activated carbon. The adsorption capacities of G, AC and GAC for Cr(VI) are 6.627, 5.455 and 6.354 mg/g with 0.02 g adsorbent within contact time of 60, 180 and 30 min for G, AC and GAC, respectively, for Cr(VI) adsorption at optimum pH of 3. The isotherm studied was best explained by Langmuir adsorption isotherm and fitted with the pseudo-second-order kinetic model. Desorption studies showed that 1.0 M HNO3 was a better desorbing agent than 0.1 M HNO3, 0.1 M HCl and 1.0 M HCl. Chromium was most desorbed (94.60% in Cr//G using 1 M HNO3). The result obtained revealed that goethite and activated carbon produced are favourable adsorbents and the composite of the two adsorbents gives a more favourable, economical and affordable adsorbent for the clean-up of heavy metal contamination.
Machine Learning-Based Detection of Graphene Defects with Atomic Precision
Authors: Zheng Bowen , Gu Grace X.
Published: September 2020

Defects in graphene can profoundly impact its extraordinary properties, ultimately influencing the performances of graphene-based nanodevices. Methods to detect defects with atomic resolution in graphene can be technically demanding and involve complex sample preparations. An alternative approach is to observe the thermal vibration properties of the graphene sheet, which reflects defect information but in an implicit fashion. Machine learning, an emerging data-driven approach that offers solutions to learning hidden patterns from complex data, has been extensively applied in material design and discovery problems. In this paper, we propose a machine learning-based approach to detect graphene defects by discovering the hidden correlation between defect locations and thermal vibration features. Two prediction strategies are developed: an atom-based method which constructs data by atom indices, and a domain-based method which constructs data by domain discretization. Results show that while the atom-based method is capable of detecting a single-atom vacancy, the domain-based method can detect an unknown number of multiple vacancies up to atomic precision. Both methods can achieve approximately a 90% prediction accuracy on the reserved data for testing, indicating a promising extrapolation into unseen future graphene configurations. The proposed strategy offers promising solutions for the non-destructive evaluation of nanomaterials and accelerates new material discoveries.
Lying to friends: Examining lie‐telling, friendship quality, and depressive symptoms over time during late childhood and adolescence
Authors: Dykstra Victoria W. , Willoughby Teena , Evans Angela D.
Published: September 2020

Introduction

Lie‐telling appears to peak during adolescence; however, previous research has not yet examined lie‐telling frequency in adolescents' friendships. Increased lie‐telling may be problematic given that honesty is crucial for trust within positive relationships, and more positive relationships lead to more positive well‐being. The present study examined adolescents’ lies to friends and longitudinal associations between lying, friendship quality, and depressive symptoms.

Methods

Canadian adolescents (Time 1: N = 1313, Mage = 11.65, SD = 11.75, 50% male) reported how often they lied to their friends about their mental health/mood, possessions, romantic relationships, school, and to avoid spending time with them. Participants also completed measures of friendship quality and depressive symptoms. Participants completed these measures at two time points one year apart.

Results

Poorer friendship quality predicted more frequent lie‐telling over time. Greater depressive symptoms predicted more frequent lie‐telling over time, and more frequent lie‐telling predicted greater depressive symptoms over time. Lies about mental health in particular were bidirectionally associated with both friendship quality and depressive symptoms over time.

Conclusions

These findings highlight the developmental importance of lie‐telling during adolescence. More negative friendships lead to greater lie‐telling over time. Additionally, increased lie‐telling predicted and is predicted by depressive symptoms, suggesting that lie‐telling may be an important indicator of poor mental health.
THE TREE OF TUPLES OF A STRUCTURE
Authors: HARRISON-TRAINOR MATTHEW , MONTALBÁN ANTONIO
Published: September 2020

Our main result is that there exist structures which cannot be computably recovered from their tree of tuples. This implies that there are structures with no computable copies which nevertheless cannot code any information in a natural/functorial way.
CONTINUOUS SENTENCES PRESERVED UNDER REDUCED PRODUCTS
Authors: GOLDBRING ISAAC , KEISLER H. JEROME
Published: September 2020

Answering a question of Cifú Lopes, we give a syntactic characterization of those continuous sentences that are preserved under reduced products of metric structures. In fact, we settle this question in the wider context of general structures as introduced by the second author.
A METRIC VERSION OF SCHLICHTING’S THEOREM
Authors: YAACOV ITAÏ BEN , WAGNER FRANK O.
Published: September 2020

If ${\mathfrak {F}}$ is a type-definable family of commensurable subsets, subgroups or subvector spaces in a metric structure, then there is an invariant subset, subgroup or subvector space commensurable with ${\mathfrak {F}}$. This in particular applies to type-definable or hyper-definable objects in a classical first-order structure.
A NOTE ON DERIVABILITY CONDITIONS
Authors: KURAHASHI TAISHI
Published: September 2020

We investigate relationships between versions of derivability conditions for provability predicates. We show several implications and non-implications between the conditions, and we discuss unprovability of consistency statements induced by derivability conditions. First, we classify already known versions of the second incompleteness theorem, and exhibit some new sets of conditions which are sufficient for unprovability of Hilbert–Bernays’ consistency statement. Secondly, we improve Buchholz’s schematic proof of provable$\Sigma_1$-completeness. Then among other things, we show that Hilbert–Bernays’ conditions and Löb’s conditions are mutually incomparable. We also show that neither Hilbert–Bernays’ conditions nor Löb’s conditions accomplish Gödel’s original statement of the second incompleteness theorem.
Ceramics in transition: ceramics from the first Islamic period in the western Mediterranean – the example of al-Andalus
Authors: Amorós Ruiz Victoria , Gutiérrez Lloret Sonia
Published: September 2020

This paper updates the present knowledge of ceramic productions in the Western Mediterranean in the early Middle Ages through the example of al-Andalus. The study of pottery production is a key element for recognizing the process of Islamization, the formation of al-Andalus, and the important social and economic changes that took placed in the Mediterranean between the seventh and ninth centuries. From a historical point of view, the early Middle Ages is a transcendental moment of change: patterns and socioeconomic models of the ancient world began to fade, and the evolution towards the development of feudal societies and, in parallel, the emergence of Islamic culture started. In the Iberian Peninsula, the arrival of the Arab-Berber army in AD 711 and its rapid conquest over a few years generated a process of social change know today as Islamization, which encompasses two centuries (eighth and ninth), and culminates in the tenth century with the standardization of a culture that is recognized from that moment on as Islamic culture. In this paper, the central elements of ceramic production in early al-Andalus are analysed, including the coexistence of diverse manufacturing techniques, the gradual disappearance of standardized productions, regionalization of production centres, and the incorporation of new forms and techniques such as glaze.
Predictors of postprandial glycaemia, insulinaemia and insulin resistance in adolescents
Authors: Williams Ryan A. , Dring Karah J. , Cooper Simon B. , Morris John G. , Sunderland Caroline , Nevill Mary E.
Published: September 2020

Postprandial glycaemia and insulinaemia are important risk factors for type 2 diabetes. The prevalence of insulin resistance in adolescents is increasing, but it is unknown how adolescent participant characteristics such as BMI, waist circumference, fitness and maturity offset may explain responses to a standard meal. The aim of the present study was to examine how such participant characteristics affect the postprandial glycaemic and insulinaemic responses to an ecologically valid mixed meal. Data from the control trials of three separate randomised, crossover experiments were pooled, resulting in a total of 108 participants (fifty-two boys, fifty-six girls; aged 12·5 (SD 0·6) years; BMI 19·05 (SD 2·66) kg/m2). A fasting blood sample was taken for the calculation of fasting insulin resistance, using the homoeostatic model assessment of insulin resistance (HOMA-IR). Further capillary blood samples were taken before and 30, 60 and 120 min after a standardised lunch, providing 1·5 g/kg body mass of carbohydrate, for the quantification of blood glucose and plasma insulin total AUC (tAUC). Hierarchical multiple linear regression demonstrated significant predictors for plasma insulin tAUC were waist circumference, physical fitness and HOMA-IR (F(3,98) = 36·78, P < 0·001, adjusted R2 = 0·515). The variance in blood glucose tAUC was not significantly explained by the predictors used (F(7,94) = 1·44, P = 0·198). Significant predictors for HOMA-IR were BMI and maturity offset (F(2,102) = 14·06, P < 0·001, adjusted R2 = 0·021). In summary, the key findings of the study are that waist circumference, followed by physical fitness, best explained the insulinaemic response to an ecologically valid standardised meal in adolescents. This has important behavioural consequences because these variables can be modified.
Chinese Aid and Local Ethnic Identification
Authors: Isaksson Ann-Sofie
Published: September 2020

Recent empirical evidence suggests that Chinese development finance may be particularly prone to elite capture and patronage spending. If aid ends up in the pockets of political elites and their ethno-regional networks, this may exacerbate ethnic grievances and contribute to ethnic mobilization. In this research note I examine whether Chinese development projects make local ethnic identities more salient in African partner countries. A new geo-referenced data set on the subnational allocation of Chinese development finance projects to Africa is geographically matched with survey data for 50,520 respondents from eleven African countries. The identification strategy compares sites where a Chinese project was under implementation at the time of the interview to sites where a Chinese project will appear subsequently. The empirical results suggest that living near an ongoing Chinese project makes ethnic identities more salient. There is no indication of an equivalent pattern when considering other donors’ development projects.
The Collapse of State Power, the Cluniac Reform Movement, and the Origins of Urban Self-Government in Medieval Europe
Authors: Doucette Jonathan Stavnskær , Møller Jørgen
Published: September 2020

Several generations of scholarship have identified the medieval development of urban self-government as crucial for European patterns of state formation. However, extant theories, emphasizing structural factors such as initial endowments and warfare, do little to explain the initial emergence of institutions of urban self-government before CE 1200 or why similar institutions did not emerge outside of Europe. We argue that a large-scale collapse of public authority in the ninth and tenth centuries allowed a bottom-up reform movement in West Francia (the Cluniac movement), directed by clergy but with popular backing, to push for ecclesiastical autonomy and asceticism in the eleventh and twelfth centuries. These social realignments, facilitated by new norms about ecclesiastical office holding, stimulated the urban associationalism that led to the initial emergence of autonomous town councils. Using a panel data set of 643 towns in the period between 800 and 1800, we show that medieval towns were substantially more likely to establish autonomous town councils in the period between 1000 and 1200 if they were situated in the vicinity of Cluniac monasteries. These findings are corroborated by regressions that use distance from Cluny—the movement's place of origin—to instrument for proximity to Cluniac monasteries.
Identification ofPseudomonas jesseniiandPseudomonas gessardiias the most proteolyticPseudomonasisolates in Iranian raw milk and their impact on stability of sterilized milk during storage
Authors: Zarei Mehdi , Mohammadpour Hooriyeh , Gharibi Darioush , Pourmahdi Borujeni Mahdi
Published: September 2020

Identification of the most proteolyticPseudomonasstrains that can produce heat-resistant proteases and contribute to the Ultra High Temperature (UHT) milk destabilization is of great interest. In the present study, among the 146Pseudomonasisolates that encoded theaprX gene, five isolates with the highest proteolytic activity were selected and identified based on 16S rRNA,rpoDandgyrBgene sequences data. The identification results were confirmed by phylogenetic analysis based on multilocus sequence analysis and identified the representative isolates asP. jessenii(two isolates) andP. gessardii(three isolates). Casein zymography demonstrated the ability of these species to produce heat-resistant enzymes, AprX, with molecular mass of about 48 kDa during storage at 7° C for 72 h. In sterilized milk samples, the residual activity of AprX caused a considerable enhancement in the degree of protein hydrolysis, non-protein nitrogen and non-casein nitrogen contents of the samples during a two-month storage. This enhancement was slightly higher in samples containing enzyme produced byP. jesseniicompared toP. gessardiiones, resulting in earlier onset of sterilized milk destabilization. Hence, this study revealed thatP. jesseniiandP. gessardiican play a considerable role in deterioration of Iranian commercial long-life milk.
The Heredity of Senatorial Status in the Principate
Authors: Weisweiler John
Published: September 2020

Since Mommsen, it has been a tenet of Roman history that Augustus transformed the ‘senatorial order’ into a hereditary class, which encompassed senators, their children, grandchildren and great-grandchildren in the male line. This paper shows that the idea of a hereditaryordo senatoriusis a myth without foundation in the evidence. Augustus and his successors conferred new rights and duties upon relatives of senators, but did not change their formal rank. Moreover, the new regulations applied not to three generations of descendants, but only to persons who stood under a senator'spatria potestasduring his lifetime. Emperors protected the honour and property of thesefilii familiasof senators, in order to incentivise them to participate in politics and invest their wealth into munificence. The Supplementary Material available online gives all known early imperial holders of the titleclarissimus virin the province of Africa (Supplementary Appendix 1), all known early imperialclarissimi iuuenes(Supplementary Appendix 2) and all known early imperialclarissimi pueri(Supplementary Appendix 3).
Promoting grazing or rewilding initiatives against rural exodus? The return of the wolf and other large carnivores must be considered
Authors: Recio Mariano R , Sand Håkan , Virgós Emilio
Published: September 2020

The human abandonment of rural areas facilitates rewilding, which is also supported by European projects and initiatives. Rewilding often implies the return of iconic predators such as the wolf (Canis lupus), leading to human–wildlife conflicts. To reverse human depopulation, initiatives such as the European Union’s Common Agricultural Policy (CAP) subsidize extensive grazing of areas unsuitable for intensive agriculture. Therefore, rewilding and reversing depopulation initiatives seem to be mutually incompatible, and further insight into controversial aspects of the return of apex predators is needed when considering the reform of the CAP for post-2020. To develop understanding of these different objectives in the context of large carnivore recolonizations, we analysed wolf attacks on livestock in central Spain, where livestock is managed differently between the plateau and the mountains. As with other European regions, this area is undergoing rural abandonment and is subsidized by the CAP. Free-roaming cattle at higher elevations were subject to increased attacks irrespective of the abundance of wild prey. Efforts to subsidize human repopulation of areas experiencing recolonization by large carnivores require consideration of a model of cohabitation with these predators assisted by mitigation and compensation measures. Rewilding could bring alternative sustainable income based on the values brought by the presence of large carnivores and associated ecosystem services.
Let’s Work Together: Assessing the Impact of Intergenerational Dynamics on Young Workers’ Ageism Awareness and Job Satisfaction
Authors: Firzly Najat , Van de Beeck Lise , Lagacé Martine
Published: September 2020

Previous studies suggest that intergroup contact has a positive effect on older workers’ perception of ageism and satisfaction. This study aims at assessing such relationships amongst Canadian younger workers. Precisely, in light of the intergroup contact theory (ICT), it was first hypothesized that a positive perception of intergenerational workplace climate (IWC) and knowledge sharing practices (KSP) increase younger workers’ awareness of ageist behaviors targeting older peers. Second, it was hypothesized that such awareness has a positive effect on young workers’ level of satisfaction. Relying on a cross-sectional design composed of 612 participants, path analysis was conducted. Findings suggest that whereas KSP increases younger workers’ awareness of ageist behaviors towards older workers, this is not the case for IWC. On the other hand, both IWC and KSP have a direct and positive impact on younger workers’ level of satisfaction. Theoretical and practical implications of findings are discussed.
Memory During the Presumed Vegetative State: Implications for Patient Quality of Life
Authors: TAYLOR NICOLA , GRAHAM MACKENZIE , DELARGY MARK , NACI LORINA
Published: September 2020

A growing number of studies show that a significant proportion of patients, who meet the clinical criteria for the diagnosis of the vegetative state (VS), demonstrate evidence of covert awareness through successful performance of neuroimaging tasks. Despite these important advances, the day-to-day life experiences of any such patient remain unknown. This presents a major challenge for optimizing the patient’s standard of care and quality of life (QoL). We describe a patient who, following emergence from a state of complete behavioral unresponsiveness and a clinical diagnosis of VS, reported rich memories of his experience during this time. This case demonstrates the potential for a sophisticated mental life enabled by preserved memory in a proportion of patients who, similarly, are thought to be unconscious. Therefore, it presents an important opportunity to examine the implications for patient QoL and standard of care, both during the period of presumed unconsciousness and after recovery.
On the Nontechnical Limits of Brain Imaging
Authors: RÄIKKÄ JUHA
Published: September 2020

Since the advent of neuroimaging technologies, their limits and possibilities have captivated scientists and philosophers. Thus far, the debate has largely concerned technical limits of our capacity to “read minds.” This paper extends the discussion concerning the limitations of neuroimaging to issues that are not dependent on technical issues or on our understanding of the complexity of brain activities. The author argues that there is a serious chance that brain scanning cannot replace usual intentional assertions, and that neuroimaging has principled limits. The information that people usually receive by neuroimaging is different in kind from the information they hear from what others tell them. To assert something is to act in a certain way, and scanners do not usually scan actions, but brain activities and the neural correlates of actions. Although it is possible to scan “mental assertions,” our usual assertions are not accompanied by separate “mental assertions.”
EFFECTS OF R&D SUBSIDIES IN A HYBRID MODEL OF ENDOGENOUS GROWTH AND SEMI-ENDOGENOUS GROWTH
Authors: Chu Angus C. , Wang Xilin
Published: September 2020

We explore R&D subsidies in a hybrid growth model which may exhibit semi-endogenous growth or fully endogenous growth. We consider two types of subsidies on variety-expanding innovation and quality-improving innovation. R&D subsidies on quality-improving innovation only have effects in the fully endogenous-growth regime, in which more subsidies cause an earlier activation of quality-improving innovation and increase the transitional/steady-state growth rate. R&D subsidies on variety-expanding innovation have contrasting effects in the two regimes. In the semi-endogenous-growth regime, more subsidies on variety-expanding innovation increase transitional growth but have no effect on steady-state growth. In the fully endogenous-growth regime, more subsidies on variety-expanding innovation continue to increase short-run growth but delay the activation of quality-improving innovation and reduce long-run growth. Increasing subsidies on variety-expanding (quality-improving) innovation makes the semi-endogenous-growth (fully endogenous-growth) regime more likely to emerge. Finally, we calibrate the model and find that under reasonable parameter values, the fully endogenous-growth regime is more likely to emerge.
The incidence of hypothyroidism in patients of head and neck carcinoma treated with radiotherapy and added risk of hypothyroidism with the addition of chemotherapy
Authors: Singh Dharmendra , Roy Niladri , Pal Suparna Kanti , Basu Siddhartha , Meyur Suman
Published: September 2020

Background:

Head and neck cancer (HNC) is the most common malignancy in the Indian males. Most of the cases of HNC present in locally advanced stage and requires a multidisciplinary management approach. Radical or adjuvant external beam radiotherapy (EBRT) is one of the important integral components of the management of HNC.

Aim:

To find the incidence of hypothyroidism (HT) in patients of HNC treated with radiotherapy with or without concurrent chemotherapy.

Methods:

A prospective, single institutional longitudinal observational study conducted at the department of radiotherapy, Institute of Post Graduate Medical Education and Research, Kolkata.

Results:

In this study, data of 118 patients were analysed. The median age at presentation was 56 years. The most common primary site of malignancy was oral cavity (39%). The patients were stage I, stage II and stage III as 11, 37·3 and 51·7% respectively. The median dose of EBRT was 66 Gy. HT statistically significantly correlated with primary site of malignancy (p = 0·001), dose of EBRT (p = 0·005). At the end of follow-up of 6 months, 39·8% developed HT.

Conclusion:

The thyroid gland is an important organ at risk while considering EBRT to neck region. The inclusion of thyroid function test in routine follow-up is mandated.
From Operation Iraqi Freedom to the Battle of Mosul: Fifteen years of displacement in Iraq
Authors: Cotter Cédric
Published: September 2020

The displacement of civilians during a protracted war is a difficult issue that deserves our attention, and Iraq is unfortunately an emblematic example of this phenomenon. Based on the literature produced by humanitarian organizations and academia, this article aims at analyzing what triggers displacement in protracted conflict, highlighting the role of international humanitarian law (IHL) violations. It discusses how Iraq has been struggling with acts of violence, hostilities and IHL violations that have generated displacement and human suffering.
Hiding in Plain Sight: The Mattachine Society’s Use of Loose Coupling as a Strategy for Covert Political Action
Authors: Jacobs Molly S.
Published: September 2020

Covert political organizing is a vital means by which subordinate groups express grievances against authorities or elites. This article develops an understanding of the process of covert organizing to show how the selection of an organizational structure is a strategic decision. Using original, archival data from the Mattachine Society, a homosexual organization founded in 1950, and the affiliated Mattachine Foundation, I show how the structure of the organizations enabled leaders to segment their audiences and adapt to challenges from outside and inside the group. In particular, I use the concept of a loosely coupled system, emphasizing relations between organizations, to show how organizations can work with varying degrees of discretion. Moreover, building off analytically similar cases in the literature, I demonstrate that a loosely coupled system enables both organizational flexibility and covert political action.
CLAH Lecture: Harrods Buenos Aires. The Case of the Unwanted Dresses, 1912–1940
Authors: Guy Donna J.
Published: September 2020

In 1912, a small department store called Harrods opened in Buenos Aires, one that by the 1920s expanded to almost a city block. Although named after the founder of the London store, the manager of Harrods London, Richard Burbidge, his son Woodman, and a few board members planned the purchase of land and opened the business, and then presented it to the entire London board. Unfamiliar with Buenos Aires, believing that women consumed more than men, and presuming that upper-class women there had the same consumer desires of those in England, the store opened catering to the upper-class female population and focused on readymade dresses. And, to the great surprise of the local manager, women of all classes did not want these dresses because they preferred to purchase cloth and take it to their dressmakers.

The dilemma facing Harrods Buenos Aires, detailed in company reports in the archive of Harrods London and in scans of Buenos Aires Harrods archives in the possession of British bookseller Jennifer Wilton-Williams, show that sales reports, rather than studies of the Argentine market like those published by the US Department of Commerce, shaped the new department store's response. Until the 1940s, Harrods Buenos Aires focused on the sale of less expensive articles that came from its dining room, its cosmetics department, and infants’ and children's clothing. Furthermore, employees purchased more than 40 percent of the clothing. Originally imagined as the flagship of the upper-class female shopper, it ended up as a store for the middle class, especially women who bought gifts and enjoyed being seen in the dining room. It closed in 1998.
Pomalidomide, bortezomib, and dexamethasone for multiple myeloma previously treated with lenalidomide (OPTIMISMM): outcomes by prior treatment at first relapse
Authors: Dimopoulos Meletios , Weisel Katja , Moreau Philippe , Anderson Larry D. , White Darrell , San-Miguel Jesus , Sonneveld Pieter , Engelhardt Monika , Jenner Matthew , Corso Alessandro , Dürig Jan , Pavic Michel , Salomo Morten , Casal Eva , Srinivasan Shankar , Yu Xin , Nguyen Tuong Vi , Biyukov Tsvetan , Peluso Teresa , Richardson Paul
Published: September 2020

In the phase 3 OPTIMISMM trial, pomalidomide, bortezomib, and dexamethasone (PVd) demonstrated superior efficacy vs bortezomib and dexamethasone (Vd) in patients with relapsed or refractory multiple myeloma previously treated with lenalidomide, including those refractory to lenalidomide. This analysis evaluated outcomes in patients at first relapse (N = 226) by lenalidomide-refractory status, prior bortezomib exposure, and prior stem cell transplant (SCT). Second-line PVd significantly improved PFS vs Vd in lenalidomide-refractory (17.8 vs 9.5 months; P = 0.0276) and lenalidomide-nonrefractory patients (22.0 vs 12.0 months; P = 0.0491), patients with prior bortezomib (17.8 vs 12.0 months; P = 0.0068), and patients with (22.0 vs 13.8 months; P = 0.0241) or without (16.5 vs 9.5 months; P = 0.0454) prior SCT. In patients without prior bortezomib, median PFS was 20.7 vs 9.5 months (P = 0.1055). Significant improvement in overall response rate was also observed with PVd vs Vd in lenalidomide-refractory (85.9% vs 50.8%; P < 0.001) and lenalidomide-nonrefractory (95.7% vs 60.0%; P < 0.001) patients, with similar results regardless of prior bortezomib or SCT. No new safety signals were observed. These data demonstrate the benefit of PVd at first relapse, including immediately after upfront lenalidomide treatment failure and other common first-line treatments.
Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
Authors: Brami-Cherrier Karen , Lewis Robert G. , Cervantes Marlene , Liu Yu , Tognini Paola , Baldi Pierre , Sassone-Corsi Paolo , Borrelli Emiliana
Published: September 2020

Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogramming in circadian gene expression in the striatum, an area involved in psychomotor and rewarding effects of drugs. This process involves the activation of peroxisome protein activator receptor gamma (PPARγ), a nuclear receptor involved in inflammatory responses. PPARγ reprogramming is altered in mice with cell-specific ablation of the dopamine D2 receptor (D2R) in the striatal medium spiny neurons (MSNs) (iMSN-D2RKO). Administration of a specific PPARγ agonist in iMSN-D2RKO mice elicits substantial rescue of cocaine-dependent control of circadian genes. These findings have potential implications for development of strategies to treat substance abuse disorders.
Engineered systems of inducible anti-repressors for the next generation of biological programming
Authors: Groseclose Thomas M. , Rondon Ronald E. , Herde Zachary D. , Aldrete Carlos A. , Wilson Corey J.
Published: September 2020

Traditionally engineered genetic circuits have almost exclusively used naturally occurring transcriptional repressors. Recently, non-natural transcription factors (repressors) have been engineered and employed in synthetic biology with great success. However, transcriptional anti-repressors have largely been absent with regard to the regulation of genes in engineered genetic circuits. Here, we present a workflow for engineering systems of non-natural anti-repressors. In this study, we create 41 inducible anti-repressors. This collection of transcription factors respond to two distinct ligands, fructose (anti-FruR) or D-ribose (anti-RbsR); and were complemented by 14 additional engineered anti-repressors that respond to the ligand isopropyl β-d-1-thiogalactopyranoside (anti-LacI). In turn, we use this collection of anti-repressors and complementary genetic architectures to confer logical control over gene expression. Here, we achieved all NOT oriented logical controls (i.e., NOT, NOR, NAND, and XNOR). The engineered transcription factors and corresponding series, parallel, and series-parallel genetic architectures represent a nascent anti-repressor based transcriptional programming structure.
Author Correction: Entanglement of propagating optical modes via a mechanical interface
Authors: Chen Junxin , Rossi Massimiliano , Mason David , Schliesser Albert
Published: September 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells
Authors: Muscarella Aaron M. , Dai Wei , Mitchell Patrick G. , Zhang Weijie , Wang Hai , Jia Luyu , Stossi Fabio , Mancini Michael A. , Chiu Wah , Zhang Xiang H.-F.
Published: September 2020

Migration and invasion are key properties of metastatic cancer cells. These properties can be acquired through intrinsic reprogramming processes such as epithelial-mesenchymal transition. In this study, we discovered an alternative “migration-by-tethering” mechanism through which cancer cells gain the momentum to migrate by adhering to mesenchymal stem cells or osteoblasts. This tethering is mediated by both heterotypic adherens junctions and gap junctions, and leads to a unique cellular protrusion supported by cofilin-coated actin filaments. Inhibition of gap junctions or depletion of cofilin reduces migration-by-tethering. We observed evidence of these protrusions in bone segments harboring experimental and spontaneous bone metastasis in animal models. These data exemplify how cancer cells may acquire migratory ability without intrinsic reprogramming. Furthermore, given the important roles of osteogenic cells in early-stage bone colonization, our observations raise the possibility that migration-by-tethering may drive the relocation of disseminated tumor cells between different niches in the bone microenvironment.
Efficient construction of linear models in materials modeling and applications to force constant expansions
Authors: Fransson Erik , Eriksson Fredrik , Erhart Paul
Published: September 2020

Linear models, such as force constant (FC) and cluster expansions, play a key role in physics and materials science. While they can in principle be parametrized using regression and feature selection approaches, the convergence behavior of these techniques, in particular with respect to thermodynamic properties is not well understood. Here, we therefore analyze the efficacy and efficiency of several state-of-the-art regression and feature selection methods, in particular in the context of FC extraction and the prediction of different thermodynamic properties. Generic feature selection algorithms such as recursive feature elimination with ordinary least-squares (OLS), automatic relevance determination regression, and the adaptive least absolute shrinkage and selection operator can yield physically sound models for systems with a modest number of degrees of freedom. For large unit cells with low symmetry and/or high-order expansions they come, however, with a non-negligible computational cost that can be more than two orders of magnitude higher than that of OLS. In such cases, OLS with cutoff selection provides a viable route as demonstrated here for both second-order FCs in large low-symmetry unit cells and high-order FCs in low-symmetry systems. While regression techniques are thus very powerful, they require well-tuned protocols. Here, the present work establishes guidelines for the design of protocols that are readily usable, e.g., in high-throughput and materials discovery schemes. Since the underlying algorithms are not specific to FC construction, the general conclusions drawn here also have a bearing on the construction of other linear models in physics and materials science.
Unusual magnetoelectric effect in paramagnetic rare-earth langasite
Authors: Weymann Lukas , Bergen Lorenz , Kain Thomas , Pimenov Anna , Shuvaev Alexey , Constable Evan , Szaller David , Mill Boris V. , Kuzmenko Artem M. , Ivanov Vsevolod Yu. , Kostyuchenko Nadezhda V. , Popov Alexander I. , Zvezdin Anatoly K. , Pimenov Andrei , Mukhin Alexander A. , Mostovoy Maxim
Published: September 2020

Violation of time reversal and spatial inversion symmetries has profound consequences for elementary particles and cosmology. Spontaneous breaking of these symmetries at phase transitions gives rise to unconventional physical phenomena in condensed matter systems, such as ferroelectricity induced by magnetic spirals, electromagnons, non-reciprocal propagation of light and spin waves, and the linear magnetoelectric (ME) effect—the electric polarization proportional to the applied magnetic field and the magnetization induced by the electric field. Here, we report the experimental study of the holmium-doped langasite, HoxLa3−xGa5SiO14, showing a puzzling combination of linear and highly non-linear ME responses in the disordered paramagnetic state: its electric polarization grows linearly with the magnetic field but oscillates many times upon rotation of the magnetic field vector. We propose a simple phenomenological Hamiltonian describing this unusual behavior and derive it microscopically using the coupling of magnetic multipoles of the rare-earth ions to the electric field.
Quantum oscillations from networked topological interfaces in a Weyl semimetal
Authors: Liu I-Lin , Heikes Colin , Yildirim Taner , Eckberg Chris , Metz Tristin , Kim Hyunsoo , Ran Sheng , Ratcliff William D. , Paglione Johnpierre , Butch Nicholas P.
Published: September 2020

Layered transition metal chalcogenides are promising hosts of electronic Weyl nodes and topological superconductivity. MoTe2 is a striking example that harbors both noncentrosymmetric Td and centrosymmetric T’ phases, both of which have been identified as topologically nontrivial. Applied pressure tunes the structural transition separating these phases to zero temperature, stabilizing a mixed Td–T’ matrix that entails a network of interfaces between the two nontrivial topological phases. Here, we show that this critical pressure range is characterized by distinct coherent quantum oscillations, indicating that the difference in topology between topologically nonvtrivial Td and T’ phases gives rise to an emergent electronic structure: a network of topological interfaces. A rare combination of topologically nontrivial electronic structures and locked-in transformation barriers leads to this counterintuitive situation, wherein quantum oscillations can be observed in a structurally inhomogeneous material. These results further open the possibility of stabilizing multiple topological phases coexisting with superconductivity.
Language disturbances in schizophrenia: the relation with antipsychotic medication
Authors: de Boer J. N. , Voppel A. E. , Brederoo S. G. , Wijnen F. N. K. , Sommer I. E. C.
Published: September 2020

Language disturbances are key aberrations in schizophrenia. Little is known about the influence of antipsychotic medication on these symptoms. Using computational language methods, this study evaluated the impact of high versus low dopamine D2receptor (D2R) occupancy antipsychotics on language disturbances in 41 patients with schizophrenia, relative to 40 healthy controls. Patients with high versus low D2R occupancy antipsychotics differed by total number of words and type-token ratio, suggesting medication effects. Both patient groups differed from the healthy controls on percentage of time speaking and clauses per utterance, suggesting illness effects. Overall, more severe negative language disturbances (i.e. slower articulation rate, increased pausing, and shorter utterances) were seen in the patients that used high D2R occupancy antipsychotics, while less prominent disturbances were seen in low D2R occupancy patients. Language analyses successfully predicted drug type (sensitivity = 80.0%, specificity = 76.5%). Several language disturbances were more related to drug type and dose, than to other psychotic symptoms, suggesting that language disturbances may be aggravated by high D2R antipsychotics. This negative impact of high D2R occupancy drugs may have clinical implications, as impaired language production predicts functional outcome and degrades the quality of life.