bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and implementation of a strategy for early diagnosis and management of scrub typhus: an emerging public health threat
Authors: Jain Hitesh Kumar , Das Arundhuti , Dixit Sujata , Kaur Harpreet , Pati Sanghamitra , Ranjit Manoranjan , Dutta Ambarish , Bal Madhusmita
Published: April 2024

Scrub typhus, caused by Orientia tsutsugamushi, is a re-emerging zoonotic disease in the tropics with considerable morbidity and mortality rates. This disease, which is mostly prevalent in rural areas, remains underdiagnosed and underreported because of the low index of suspicion and non-specific clinical presentation. Limited access to healthcare, diagnostics, and treatment in rural settings further makes it challenging to distinguish it from other febrile illnesses. While easily treatable, improper treatment leads to severe forms of the disease and even death. As there is no existing public health program to address scrub typhus in India, there is an urgent need to design a program and test its effectiveness for control and management of the disease. With this backdrop, this implementation research protocol has been developed for a trial in few of the endemic “pockets” of Odisha, an eastern Indian state that can be scalable to other endemic areas of the country, if found effective. The main goal of the proposed project is to include scrub typhus as a differential diagnosis of fever cases in every tier of the public health system, starting from the community level to the health system, for the early diagnosis among suspected cases and to ensure that individuals receive complete treatment. The current study aimed to describe the protocol of the proposed Scrub Typhus Control Program (STCP) in detail so that it can receive valuable views from peers which can further strengthen the attempt.
Evaluating tactile feedback in addition to kinesthetic feedback for haptic shape rendering: a pilot study
Authors: Ratschat Alexandre L. , van Rooij Bob M. , Luijten Johannes , Marchal-Crespo Laura
Published: April 2024

In current virtual reality settings for motor skill training, only visual information is usually provided regarding the virtual objects the trainee interacts with. However, information gathered through cutaneous (tactile feedback) and muscle mechanoreceptors (kinesthetic feedback) regarding, e.g., object shape, is crucial to successfully interact with those objects. To provide this essential information, previous haptic interfaces have targeted to render either tactile or kinesthetic feedback while the effectiveness of multimodal tactile and kinesthetic feedback on the perception of the characteristics of virtual objects still remains largely unexplored. Here, we present the results from an experiment we conducted with sixteen participants to evaluate the effectiveness of multimodal tactile and kinesthetic feedback on shape perception. Using a within-subject design, participants were asked to reproduce virtual shapes after exploring them without visual feedback and with either congruent tactile and kinesthetic feedback or with only kinesthetic feedback. Tactile feedback was provided with a cable-driven platform mounted on the fingertip, while kinesthetic feedback was provided using a haptic glove. To measure the participants’ ability to perceive and reproduce the rendered shapes, we measured the time participants spent exploring and reproducing the shapes and the error between the rendered and reproduced shapes after exploration. Furthermore, we assessed the participants’ workload and motivation using well-established questionnaires. We found that concurrent tactile and kinesthetic feedback during shape exploration resulted in lower reproduction errors and longer reproduction times. The longer reproduction times for the combined condition may indicate that participants could learn the shapes better and, thus, were more careful when reproducing them. We did not find differences between conditions in the time spent exploring the shapes or the participants’ workload and motivation. The lack of differences in workload between conditions could be attributed to the reported minimal-to-intermediate workload levels, suggesting that there was little room to further reduce the workload. Our work highlights the potential advantages of multimodal congruent tactile and kinesthetic feedback when interacting with tangible virtual objects with applications in virtual simulators for hands-on training applications.
How does embracing an outdoor lifestyle and sense of responsibility impact plastic reduction efforts?
Authors: Riordan Oliver , Richter Isabell
Published: April 2024

Introduction

Plastic pollution in coastal regions poses severe environmental challenges. This research aims to examine the impact of an individual's outdoor lifestyle and their perceptions of responsibility for litter management-specifically the roles of governments, businesses, non-governmental organizations (NGOs), Cornwall council, and volunteers-on their engagement in activities aimed at reducing plastic pollution.

Methods

The study surveyed 972 individuals in Cornwall, UK, to gather data on their perceptions and behaviors related to plastic reduction initiatives. The survey employed binomial logistic regression tests to analyse the relationship between respondents' views on responsibility for litter management and their participation in ten different plastic-reducing activities.

Results

The analysis revealed that individuals' perceptions of who should be responsible for managing litter significantly influence their likelihood of participating in plastic reduction activities. Notably, respondents who viewed national governments, businesses, and volunteers as responsible were more likely to engage in outdoor plastic reduction efforts, such as beach clean-ups. In contrast, attributing responsibility to the Cornwall council and NGOs was negatively correlated with participation in some plastic-reducing activities.

Discussion

The findings suggest that perceptions of responsibility play a crucial role in motivating individuals to participate in plastic reduction efforts. The positive correlation between viewing certain entities (governments, businesses, and volunteers) as responsible and increased participation highlights the potential for targeted interventions. Recommendations for enhancing plastic reduction participation include governmental policy changes, collaboration with outdoor sports groups, and the implementation of community-focused social marketing strategies to foster a collective sense of responsibility and action.
Coaching adaptive skill and expertise in Premier League football academies—paving a way forward for research and practice
Authors: Ashford Michael , Taylor Jamie , Newcombe Danny , MacNamara Áine , Behan Stephen , Phelan Simon , McNeill Scott
Published: April 2024

Within the domain of coach education researchers have long called for a paradigm shift, whereby the quality of coaching practice is no longer measured against a checklist of prescribed competencies. This desire to evolve coach education and development, has been aligned to the need to better identify, understand and utilise what adaptive skill and expertise looks, sounds and feels like across specific sport coaching contexts. This paper outlines a broader research plan for the Premier League to drive the progress of research informed practice, in turn shaping a coach development agenda focused on developing adaptive and skilful coaches within Academies. In turn, this is a core feature of the Premier Leagues institutional aim of developing the most skilful coaches in the world. However, in order to begin the process of initiating such a shift in the way things work, there is a need to seek first to understand, before being understood. Therefore, to demonstrate an evidence informed basis to this shift within coach education and development, we ask three questions; (1) Do we understand what the coaches with the highest level of expertise can do? (2) How should we identify coaches with expertise across different contexts? (3) What does coaching expertise research need to do? In answer to these questions, we present the lack of empirical investigation previously conducted in the sports coaching discipline to explore coaching expertise and draw on wider domains to offer possible capacities of skilful coaches who possess expertise. To identify coaches with expertise, coherent with the broader expertise literature, we suggest that this is best conducted via means of social validation. Finally, we offer a road map of investigation designed to explore expertise, formed of a mix of evidence informed methodologies which have not yet been utilised in sport coaching research.
Plant protein-derived peptides: frontiers in sustainable food system and applications
Authors: Nirmal Nilesh , Khanashyam Anandu Chandra , Shah Kartik , Awasti Nancy , Sajith Babu Karthik , Ucak İlknur , Afreen Maliha , Hassoun Abdo , Tuanthong Arthittaya
Published: April 2024

Plant proteins have been considered a potential source of bio-functional peptides, which can be beneficial for human health. The potent antioxidant properties of plant-based peptides protect against oxidative damage and associated diseases. Despite a significant number of studies on the preparation and biological functions of plant-based peptides, only a limited number of peptides are commercially utilized. The systematic studies of the extraction, optimization, isolation, pharmacokinetics, stability, and safety aspects of plant protein-derived peptides (PPDP) are in progress. Also, the molecular mechanism of action and health benefits of bioactive PPDP is still lacking. Hence, this review provides a comprehensive discussion of various plant protein sources to end-product applications of PPDP. In this context, different plant sources explored for functional and bioactive PPDP have been presented. The green biotechnological techniques such as fermentation and enzymatic hydrolysis for extraction of PPDP have been described. The functional and biological properties of PPDP have been revisited. The most important part of the application which includes the stability and bioavailability of PPDP has been discussed. Additionally, the health impact of PPDP administration has been summarized. Lastly, future perspectives and concluding remarks have been documented.
Identifying optimal candidates for primary tumor surgery in patients with metastatic head and neck cancer
Authors: Liang Qi-Wei , Zhuang Shuang-Hao , Li Sheng
Published: April 2024

Background

Primary tumor surgery (PTS) may enhance survival among part of patients with metastatic head and neck cancer (mHNC). Herein, a predictive model was needed to construct to identify who can gain benefit remarkably from tumor resection.

Methods

Data of patients with mHNC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The best cut-off value of age were analyzed using the X-tile software. One-to-one PSM, Kaplan–Meier method, and log-rank test were performed for survival analysis.The independent factors determined using the multivariate Cox proportional hazard regression were used to construct the nomogram.

Results

A total of 1,614 patients diagnosed with mHNC were included; among them, 356 (22.0%) underwent a surgical procedure for the excision of the primary tumor. cancer-specific survival (CSS) was remarkably prolonged in the PTS group relative to the non-PTS group following PSM [Median:19 months vs. 9 months; hazard ratio (HR) 0.52, P < 0.001]. Patients with mHNC who were younger than 52 years old, had well-differentiated tumors, had T1 and N0 stages, and were married at the time of the study may have significantly benefited from PTS. In addition, we constructed a nomogram based on the factors that independently affect the CSS in multivariate Cox analysis. The nomogram showed excellent discrimination in both the training and validation sets (AUC: 0.732 and 0.738, respectively).

Conclusion

A practical predictive model was constructed to determine the appropriate patients with mHNC, who would benefit from surgical resection.
“No Need to Dress to Impress” Evidence on Teleworking during and after the Pandemic: A Systematic Review
Authors: Almeida Filomena , Rodrigues Helena , Freitas Patrícia
Published: April 2024

Due to the working conditions imposed by the COVID-19 pandemic, teleworking also known as remote work has witnessed an increase in use, prompting a resurgence of interest in the topic among researchers. This article analyzes the evolution of literature before, during, and after the pandemic, as well as the research foci through an application of the antecedents, decisions, and outcomes framework. A systematic literature review methodology was employed using the evidence from 136 articles from 2016 to 2023. This review is about ‘telework literature in business, management, and accounting areas published in English’. Opportunities are identified for future studies and the findings afford managers with the advantage of understanding the crucial dimensions of telework. The bibliometric analysis revealed the significant impact of the COVID-19 pandemic on the widespread acceptance of teleworking globally, accompanied by a surge in studies on this subject. Additionally, the study provides deeper insights into the progression of teleworking literature since 2016 and organizes the various topics explored in this field.
Identification of Plant and Soil Characteristics Affecting Stability of Winter Wheat Cultivar in Temperate Climates
Authors: Ghafoor Abu Zar , Derejko Adriana , Studnicki Marcin
Published: April 2024

This study examines the significant variability in grain yield, thousand-grain weight, protein content, sedimentation value, and falling number among winter wheat cultivars across diverse trial locations, elucidating the profound influence of environmental factors on these traits. Employing Shukla’s stability variance and a multi-trait stability index (MTSI), cultivar stability is comprehensively assessed across multiple traits. Cultivars are ranked based on stability variance and cumulative ranking across all traits, with Bataja emerging as the most stable cultivar according to Shukla variance, while Apostel exhibits the lowest stability. Contrarily, MTSI rankings reveal distinct top performers, such as Medalistika and KWS Spencer. Canonical correspondence analysis (CCA) is utilized to discern relationships between stability and genotype characteristics, as well as trait values and soil properties/weather conditions. These findings contribute to the recommendation of stable cultivars for breeding programs and the optimization of crop management practices. Furthermore, this study underscores the need to explore causal relationships between accompanying variables, facilitating informed recommendations for plant breeders and advancing breeding progress amidst a changing climate. The use of multivariate statistical methods, including CCA, enhances our understanding of cultivar traits and stability, offering valuable insights for sustainable agriculture.
Inversion of Soil Moisture Content in Cotton Fields Using GBR-RF Algorithm Combined with Sentinel-2 Satellite Spectral Data
Authors: Li Xu , Wu Jingming , Yu Jun , Zhou Zhengli , Wang Qi , Zhao Wenbo , Hu Lijun
Published: April 2024

Soil moisture content plays a vital role in agricultural production, significantly influencing crop growth, development, and yield. Thoroughly understanding the specific soil moisture content in cotton fields is crucial for enhancing agricultural efficiency and driving sustainable agricultural development. This study utilized the gradient-boosting regression–random forest (GBR-RF) algorithm and the GBR and RF algorithms separately, in conjunction with Sentinel-2 satellite images, to estimate cotton soil moisture content, focusing on the B1–B8 bands and in particular the sensitive B6, B7, and B8 bands. The soil data in the jujube orchard of the study area were collected using soil augers at a depth of 30 cm, with soil data collected from a depth of 20 to 30 cm. The findings revealed that the integrated learning algorithm GBR-RF demonstrated high accuracy, with R2, MAE, and MSE results of 0.8838, 1.0121, and 1.6168, respectively. In comparison, the results using just the GBR algorithm yielded R2, MAE, and MSE values of 0.8158, 1.1327, and 1.9645, respectively, while those obtained from the RF algorithm were 0.8415, 1.0680, and 1.8331, respectively. These results indicate that the algorithms exhibited strong generalization, robustness, and accuracy, with GBR-RF outperforming GBR and RF by 8.34% and 5.03%, respectively, in combination with using the B1–B8 bands for inversion. Furthermore, utilizing the full-band data resulted in R2 values that were up to 24.27% higher than those of the individual bands, affirming the efficacy of band combinations for improved accuracy. This study’s demonstration of the positive impact of integrated learning algorithms on estimating cotton soil moisture content underscores the advantages of multi-band data combinations over single-band data, highlighting their ability to enhance accuracy without significantly impacting errors. Importantly, this study’s findings, while not limited to a single experimental field, have broad applicability in cotton precision agriculture, offering valuable insights for research on yield enhancement and agricultural efficiency.
Trophic Niche Differentiation in Two Sympatric Nuthatch Species (Sitta yunnanensis and Sitta nagaensis)
Authors: Guo Qiang , Lu Xi , Xie Chongxin , Zhang Jiansong , Xu Xianyin , Qian Yuhan , Luo Xu , Duan Yubao
Published: April 2024

Sympatric closely related species may experience interspecific trophic competition due to ecological similarity; they may isolate in terms of diet or habitat use as a strategy to avoid competition. The body tissues of consumers contain stable isotope signatures information that can be applied to infer their dietary information. In this study, δ13C and δ15N stable isotopes were analyzed to determine the dietary information and trophic niches of sympatric coexisting Sitta yunnanensis and Sitta nagaensis. The results showed that the food sources of S. yunnanensis and S. nagaensis were from six orders, including Orthoptera, and the cumulative contribution rate was 99.97%, with the two species eating similar diets but at different rates. The larger δ13C of S. yunnanensis indicates that it had a wider range of habitats for feeding, while the difference in δ15N values was not significant (p > 0.05), indicating that both species feed on similar nutrient levels. As determined by Bayesian ellipses, the isotopic niches of S. yunnanensis and S. nagaensis were differentiated; the isotopic niche width of S. yunnanensis is 2.69‰2, which was larger than that of S. nagaensis (0.73‰2), indicates that differentiation between the two species in diet or habitat use reduced competition. Trophic niche differentiation and differences in foraging proportions may be the principal resource allocation mechanisms behind S. yunnanensis and S. nagaensis coexistence.
Effects of Growth Hormone-Releasing Hormone (GHRH) Plasmid Treatment on the Reproductive Productivity of Sows in Primiparous and Multiparous Sow Breeds
Authors: Kim Min Jung , Park Ji-Yong , Cho Chang-Soo , Yang Ye Jin , Heo Ji Woong , Kim Woo H. , Lee Hu-Jang , Park Kwang Il
Published: April 2024

The effect of growth hormone-releasing hormone (GHRH) plasmid treatment on sow reproductive performance was examined. Forty pregnant sows (three-way crossbreed: Landrace × Yorkshire × Duroc) at 85 days of gestation were included in the study and consisted of twenty primiparous and twenty multiparous sows (third parity). Sows were randomly assigned to the control and treatment groups. The treatment group received 5 mg dose of GHRH plasmid injection via electroporation, whereas the control group received a phosphate buffer solution. Reproductive indicators, including serum insulin-like growth factor-1 (IGF-1) concentration and weaned piglet data, were assessed. In the GHRH plasmid-treated group, serum IGF-1 concentration significantly increased compared with that in the control group, a trend observed in primiparous and multiparous sows. The key indicator of reproductive performance, litter size, showed that for control primiparous sows (C-PS), it was 10.90 ± 0.99 kg, while for control multiparous sows (C-MS), it was 14.00 ± 0.67 kg. Furthermore, for primiparous sows treated with GHRH plasmid (G-PS), the litter size was 11.60 ± 0.97 kg, and for multiparous sows treated with GHRH plasmid (G-MS), it was 14.00 ± 0.82 kg. The GHRH plasmid-treated group also exhibited a higher number of total births and surviving piglet numbers, along with a decrease in stillborn piglets; however, there was no significant difference in birth weight. The results suggest that GHRH plasmid treatment can enhance the reproductive performance of sows.
A Method for Assessing Dogs in a Test Evaluating Dogs’ Suitability for Animal-Assisted Education
Authors: Stempiń Weronika , Strychalski Janusz
Published: April 2024

In objective behavioral rating (BR), dogs are rated for behavior based on the observations made during a behavioral test. However, behavioral definitions can differ between raters, and the definitions proposed by artificial intelligence (AI) can help standardize the applied measures. The aim of this study was to propose a new approach for assessing dogs’ suitability for animal-assisted education (AAE) with the use of the BR method and the definitions of dog behaviors proposed by AI. The analysis relied on video footage of 25 dogs that participated in tests assessing the animals’ suitability for AAE. The dogs were rated by five independent observers. Inter-rater reliability was satisfactory in 7 out of 9 subtests (0.715–0.856) and low in the remaining 2 subtests (0.667 in Subtest 2 and 0.617 in Subtest 5). The results indicate that the BR method based on AI definitions produced satisfactory inter-rater reliability in a test evaluating dog behavior. A comparison of subtest scores in the BR method and the subjective rating method did not reveal significant differences. Thus, it can be concluded that the proposed approach gives promising outcomes and can be used to develop new tests for assessing dogs’ suitability for AAE and, perhaps, other types of work.
Addressing Challenges in Wildlife Rehabilitation: Antimicrobial-Resistant Bacteria from Wounds and Fractures in Wild Birds
Authors: Sánchez-Ortiz Esther , Blanco Gutiérrez María del Mar , Calvo-Fernandez Cristina , Mencía-Gutiérrez Aida , Pastor Tiburón Natalia , Alvarado Piqueras Alberto , Pablos-Tanarro Alba , Martín-Maldonado Bárbara
Published: April 2024

Injuries and bone fractures are the most frequent causes of admission at wildlife rescue centers. Wild birds are more susceptible to open fractures due to their anatomical structure, which can lead to osteomyelitis and necrosis. Antibiotic therapy in these cases is indispensable, but the increase of antimicrobial-resistant isolates in wildlife has become a significant concern in recent years. In this context, the likelihood of antibiotic failure and death of animals with infectious issues is high. This study aimed to isolate, identify, and assess the antimicrobial resistance pattern of bacteria in wounds and open fractures in wild birds. To this end, injured birds admitted to a wildlife rescue center were sampled, and bacterial isolation and identification were performed. Then, antimicrobial susceptibility testing was assessed according to the disk diffusion method. In total, 36 isolates were obtained from 26 different birds. The genera detected were Staphylococcus spp. (63.8%), Escherichia (13.9%), Bacillus (11.1%), Streptococcus (8.3%), and Micrococcus (2.8%). Among Staphylococcus isolates, S. lentus and S. aureus were the most frequent species. Antimicrobial resistance was detected in 82.6% of the isolates, among which clindamycin resistance stood out, and 31.6% of resistant isolates were considered multidrug-resistant. Results from this study highlight the escalating scope of antimicrobial resistance in wildlife. This level of resistance poses a dual concern for wildlife: firstly, the risk of therapeutic failure in species of significant environmental value, and, secondly, the circulation of resistant bacteria in ecosystems.
Parasitic Characteristics of Ticks (Acari: Ixodidae) Collected from Water Deer (Hydropotes inermis argyropus) and Spatiotemporal Distribution Prediction within Host-Influenced Cultivated Areas
Authors: Kim Kiyoon , Kim Kyungmin , Yoon Kwangbae , Park Yungchul
Published: April 2024

Tick-borne diseases result from human–ixodid tick encounters, making it crucial to understand host–ixodid tick interactions and host-dependent distribution for epidemiology and prevention. This study examines water deer patterns and ixodid tick interactions in designated croplands of South Korea over two years, finding that the highest deer presence occurred in July and the lowest in May, during crop harvesting. Four tick species were identified, with Haemaphysalis longicornis being predominant (92.2%). Tick life stage analysis revealed peak nymphs and adults in July and larvae in October. Nymph abundance correlated positively with nearby water deer. MaxEnt biodiversity prediction results indicated wider water deer distribution in summer, reflecting their tendency to use multiple croplands. Areas with nymphs and adults aligned with predicted deer presence in summer, while larval areas aligned in autumn. Increased agroforestry expanded water deer habitats, enhancing tick dispersion. Prevention involved minimizing human–deer encounters by strategic land use in tick-prone areas. This comprehensive study provides insights into preventing severe fever with thrombocytopenia syndrome in agricultural workers, emphasizing the need for targeted interventions based on host behavior and tick life stages in different seasons.
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway
Authors: Dong Minghui , Yang Ziying , Gao Qian , Deng Qingyuan , Li Le , Chen Hongmei
Published: April 2024

2,2′,4,4′-Tetrabrominated biphenyl ether (BDE-47) is a polybrominated diphenyl ether (PBDE) homologue that is ubiquitous in biological samples and highly toxic to humans and other organisms. Prior research has confirmed that BDE-47 can induce oxidative damage in RAW264.7 cells, resulting in apoptosis and impaired immune function. The current study mainly focused on how Isoliquiritigenin (ISL) and Licochalcone B (LCB) might protect against BDE-47’s immunotoxic effects on RAW264.7 cells. The results show that ISL and LCB could increase phagocytosis, increase the production of MHC-II, and decrease the production of inflammatory factors (TNF-α, IL-6, and IL-1β) and co-stimulatory factors (CD40, CD80, and CD86), alleviating the immune function impairment caused by BDE-47. Secondly, both ISL and LCB could reduce the expressions of the proteins Bax and Caspase-3, promote the expression of the protein Bcl-2, and reduce the apoptotic rate, alleviating the apoptosis initiated by BDE-47. Additionally, ISL and LCB could increase the levels of antioxidant substances (SOD, CAT, and GSH) and decrease the production of reactive oxygen species (ROS), thereby counteracting the oxidative stress induced by BDE-47. Ultimately, ISL and LCB suppress the NF-κB pathway by down-regulating IKBKB and up-regulating IκB-Alpha in addition to activating the Nrf2 pathway and promoting the production of HO-1 and NQO1. To summarize, BDE-47 causes oxidative damage that can be mitigated by ISL and LCB through the activation of the Nrf2 pathway and inhibition of the NF-κB pathway, which in turn prevents immune function impairment and apoptosis. These findings enrich the current understanding of the toxicological molecular mechanism of BDE-47 and the detoxification mechanism of licorice.
A New Shear Strength Model with Structural Damage for Red Clay in the Qinghai-Tibetan Plateau
Authors: Yu Yanhai , Zhang Zhihong , Dai Fuchu , Bai Shunguo
Published: April 2024

Under the background of climate warming in the Qinghai-Tibetan Plateau (QTP), frequent freeze–thaw cycling (FTC) brings about great geological disasters such as subgrade failure, landslides, and mudslides, which is closely related to the strength reduction caused by the structural damage of soils. In this study, to explore the association between macro shear strength and microstructure evolution of soils subjected to FTC, the red clay distributed widely in the QTP was chosen and used to conduct a series of triaxial shear and nuclear magnetic resonance (NMR) tests in the range of 1 to 7 FTCs. Triaxial shear test results reveal that the shear strength reduction of specimens mainly occurs within five FTCs, and the trend of peak deviator stress with increasing FTCs can be described in three stages: rapid descent (FTCs less than three), slow descent (FTCs between three and five), and stabilization (FTCs greater than five). NMR tests show that the T2 spectrum curves exhibit a distinct bimodal distribution characteristic, corresponding to macropores and micropores. Part of the micropores gradually develop into macropores with increasing FTCs, especially within five FTCs. The increase in macropores proportion leads to a loose soil structure, which is consistent with the deterioration of the shear strength of specimens. Finally, based on the experimental results and classical Mohr–Coulomb theory, a new shear strength model with structural damage for red clay has been proposed by introducing a damage factor expressed by T2 spectral area.
Optical Design and Stray Light Analysis of Underwater Spectral Radiometer
Authors: Zhang Yisu , Wang Kai , Yue Wei , Liu Shuangkui , Yu Jieling , Ye Xin
Published: April 2024

Underwater spectral detection plays an important role in the study of the underwater environment, ecology, oceanography, and environmental monitoring. A kind of underwater spectral radiometer that can observe the distribution of underwater spectral radiation bidirectionally has been developed. The flat-field concave holographic grating is used as the only optical component, the optical design parameters are optimized, and the system is miniaturized. The mechanism of stray light generation in the spectrometer is studied, and a method of suppressing stray light is proposed and simulated. The level of stray light in the system is suppressed to the order of 10−4, the signal-to-noise ratio of the system is improved, and the ability to detect weak light is enhanced. The wavelength calibration experiment was completed, and the experimental results show that the wavelength resolution of the underwater spectral radiometer is better than 3 nm. Finally, the quantitative relationship between spectral irradiance and digital output is obtained through radiation in the calibration of the system.
Using Bayesian Regularized Artificial Neural Networks to Predict the Tensile Strength of Additively Manufactured Polylactic Acid Parts
Authors: Vendittoli Valentina , Polini Wilma , Walter Michael S. J. , Geißelsöder Stefan
Published: April 2024

Additive manufacturing has transformed the production process by enabling the construction of components in a layer-by-layer approach. This study integrates Artificial Neural Networks to explore the nuanced relationship between process parameters and mechanical performance in Fused Filament Fabrication. Using a fractional Taguchi design, seven key process parameters are systematically varied to provide a robust dataset for model training. The resulting model confirms its accuracy in predicting tensile strength. In particular, the mean squared error is 0.002, and the mean absolute error is 0.024. These results significantly advance the understanding of 3D manufactured parts, shedding light on the intricate dynamics between process nuances and mechanical outcomes. Furthermore, they underscore the transformative role of machine learning in precision-driven quality prediction and optimization in additive manufacturing.
A New Simple Method for the Determination of Complex Wine Aroma Compounds Using GC-MS/MS—The Case of the Greek Variety “Agiorgitiko”
Authors: Ligas Ioannis , Goulioti Elli , Tarantilis Petros , Kotseridis Yorgos
Published: April 2024

Wine exerts a fundamental influence on the global market, and its aroma remains a crucial attribute contributing to its commercial value. The market could benefit significantly if a simple and cheap method of analyzing a wine’s aromatic profile were developed. The purpose of this study is to develop such a method. A multi-analytical method for quantifying 39 volatile compounds of wine aroma was developed and validated using liquid–liquid extraction and gas chromatography/mass spectrometry/mass spectrometry (GC-MS/MS). The method was validated for its linearity, reproducibility, recovery, limit of detection, and limit of quantification and showed excellent results for almost all compounds. The method was applied to 25 commercial Protected Designation of Origin “Nemea” wines, and the results were compared and correlated with the sensory analysis results by a trained panel. The correlations among the parameters indicated that the newly developed GC-MS/MS method produces similar results to human responses.
Queer Nightlife and Contemporary Art Networks: A Study of Artists at the Bar
Authors: Valencia Joseph Daniel
Published: April 2024

This article positions queer nightlife as a central vehicle in the lives and practices of queer Latinx artists working in Los Angeles over the past decade. It highlights how queer nightlife has provided a generative space for art making and community building in LA and considers how the usage of queer nightlife as a frame of study ruptures existing art historical and curatorial methodologies relative to Latinx art. I closely analyze works by artists rafa esparza, Sebastian Hernandez, and Gabriela Ruiz drawn from the gay bars and streets of downtown and East Los Angeles to underscore the radical and sophisticated ways by which these artists create art, community, and opportunity. By critically examining three case studies—Escandalos Angeles (2018), a performance by Hernandez and Ruiz at Club Chico in Montebello, California; Nostra Fiesta (2019), a storefront mural by esparza, Ruiz, and friends at the New Jalisco Bar in downtown; and YOU (2019–ongoing), a queer party directed by Hernandez and launched at La Cita Bar in downtown—I reveal how queer nightlife has served as an incubator for these artists to come together, express themselves, and generate a sense of joy and freedom from the struggles of everyday life.
Bioinspired and Photo-Clickable Thiol-Ene Bioinks for the Extrusion Bioprinting of Mechanically Tunable 3D Skin Models
Authors: Bebiano Luís B. , Presa Rafaela , Vieira Francisca , Lourenço Bianca N. , Pereira Rúben F.
Published: April 2024

Bioinks play a fundamental role in skin bioprinting, dictating the printing fidelity, cell response, and function of bioprinted 3D constructs. However, the range of bioinks that support skin cells’ function and aid in the bioprinting of 3D skin equivalents with tailorable properties and customized shapes is still limited. In this study, we describe a bioinspired design strategy for bioengineering double crosslinked pectin-based bioinks that recapitulate the mechanical properties and the presentation of cell-adhesive ligands and protease-sensitive domains of the dermal extracellular matrix, supporting the bioprinting of bilayer 3D skin models. Methacrylate-modified pectin was used as a base biomaterial enabling hydrogel formation via either chain-growth or step-growth photopolymerization and providing independent control over bioink rheology, as well as the mechanical and biochemical cues of cell environment. By tuning the concentrations of crosslinker and polymer in bioink formulation, dermal constructs were bioprinted with a physiologically relevant range of stiffnesses that resulted in strikingly site-specific differences in the morphology and spreading of dermal fibroblasts. We also demonstrated that the developed thiol-ene photo-clickable bioinks allow for the bioprinting of skin models of varying shapes that support dermis and epidermis reconstruction. Overall, the engineered bioinks expand the range of printable biomaterials for the extrusion bioprinting of 3D cell-laden hydrogels and provide a versatile platform to study the impact of material cues on cell fate, offering potential for in vitro skin modeling.
Non-Invasive Biosensing for Healthcare Using Artificial Intelligence: A Semi-Systematic Review
Authors: Islam Tanvir , Washington Peter
Published: April 2024

The rapid development of biosensing technologies together with the advent of deep learning has marked an era in healthcare and biomedical research where widespread devices like smartphones, smartwatches, and health-specific technologies have the potential to facilitate remote and accessible diagnosis, monitoring, and adaptive therapy in a naturalistic environment. This systematic review focuses on the impact of combining multiple biosensing techniques with deep learning algorithms and the application of these models to healthcare. We explore the key areas that researchers and engineers must consider when developing a deep learning model for biosensing: the data modality, the model architecture, and the real-world use case for the model. We also discuss key ongoing challenges and potential future directions for research in this field. We aim to provide useful insights for researchers who seek to use intelligent biosensing to advance precision healthcare.
Innovative Detection of Biomarkers Based on Chemiluminescent Nanoparticles and a Lensless Optical Sensor
Authors: Potrich Cristina , Palmara Gianluca , Frascella Francesca , Pancheri Lucio , Lunelli Lorenzo
Published: April 2024

The identification and quantification of biomarkers with innovative technologies is an urgent need for the precise diagnosis and follow up of human diseases. Body fluids offer a variety of informative biomarkers, which are traditionally measured with time-consuming and expensive methods. In this context, lateral flow tests (LFTs) represent a rapid and low-cost technology with a sensitivity that is potentially improvable by chemiluminescence biosensing. Here, an LFT based on gold nanoparticles functionalized with antibodies labeled with the enzyme horseradish peroxidase is combined with a lensless biosensor. This biosensor comprises four Silicon Photomultipliers (SiPM) coupled in close proximity to the LFT strip. Microfluidics for liquid handling complete the system. The development and the setup of the biosensor is carefully described and characterized. C-reactive protein was selected as a proof-of-concept biomarker to define the limit of detection, which resulted in about 0.8 pM when gold nanoparticles were used. The rapid readout (less than 5 min) and the absence of sample preparation make this biosensor promising for the direct and fast detection of human biomarkers.
Multi-Functional Nano-Doped Hollow Fiber from Microfluidics for Sensors and Micromotors
Authors: Wang Yanpeng , Wang Zhaoyang , Sun Haotian , Lyu Tong , Ma Xing , Guo Jinhong , Tian Ye
Published: April 2024

Nano-doped hollow fiber is currently receiving extensive attention due to its multifunctionality and booming development. However, the microfluidic fabrication of nano-doped hollow fiber in a simple, smooth, stable, continuous, well-controlled manner without system blockage remains challenging. In this study, we employ a microfluidic method to fabricate nano-doped hollow fiber, which not only makes the preparation process continuous, controllable, and efficient, but also improves the dispersion uniformity of nanoparticles. Hydrogel hollow fiber doped with carbon nanotubes is fabricated and exhibits superior electrical conductivity (15.8 S m−1), strong flexibility (342.9%), and versatility as wearable sensors for monitoring human motions and collecting physiological electrical signals. Furthermore, we incorporate iron tetroxide nanoparticles into fibers to create magnetic-driven micromotors, which provide trajectory-controlled motion and the ability to move through narrow channels due to their small size. In addition, manganese dioxide nanoparticles are embedded into the fiber walls to create self-propelled micromotors. When placed in a hydrogen peroxide environment, the micromotors can reach a top speed of 615 μm s−1 and navigate hard-to-reach areas. Our nano-doped hollow fiber offers a broad range of applications in wearable electronics and self-propelled machines and creates promising opportunities for sensors and actuators.
Validation of the Standardized Needs Evaluation Questionnaire in Polish Cancer Patients
Authors: Osowiecka Karolina , Dolińska Anna , Szwiec Marek , Działach Eliza , Nowakowski Jacek J. , Rucińska Monika
Published: April 2024

Background: Cancer influences various aspects of patients’ functioning. Cancer patients face not only medical problems but also organizational, socio-psychological, and spiritual problems. Their needs often seem to be unrecognized because patients do not express their concerns and clinicians do not ask appropriate questions. Unmet needs impact patients’ quality of life. The aim of this study was to select, adapt, validate, and introduce a simple instrument for estimating cancer patients’ unmet needs in Poland. Methods: The Needs Evaluation Questionnaire (NEQ) was chosen for validation in a Polish population. The Polish version of the NEQ was developed with a back-translation procedure, as approved by a psycho-oncologist and a public health specialist. The psychometric properties of the NEQ (content analysis, reliability, construct validity, comprehensibility, and acceptability) were measured. Results: This study was performed on a group of 121 cancer patients. The median time of completion for the NEQ was 10 min. The form, length, and font size of the NEQ were accepted by the respondents. Overall, the meaning of the questions was well understood, with only a few cases of discreetly heterogeneous interpretation of the content. The questionnaire showed good reliability and internal factor structure validity. Conclusion: The NEQ is a simple, easy-to-administer instrument with good psychometric properties and seems to be useful in assessing the unexpressed needs of cancer patients.
Predictive Value of the Mayo Adhesive Probability (MAP) Score in Laparoscopic Partial Nephrectomies: A Systematic Review from the EAU Section of Uro-Technology (ESUT)
Authors: Kallidonis Panagiotis , Spinos Theodoros , Zondervan Patricia , Nyirády Peter , Backhaus Miguel Ramírez , Micali Salvatore , Hruby Stephan , Alvarez-Maestro Mario , Tatanis Vasileios , Liatsikos Evangelos , Gözen Ali Serdar
Published: April 2024

The Mayo Adhesive Probability (MAP) score is a radiographic scoring system that predicts the presence of adherent perinephric fat (APF) during partial nephrectomies (PNs). The purpose of this systematic review is to summarize the current literature on the application of the MAP score for predicting intraoperative difficulties related to APF and complications in laparoscopic PNs. Three databases, PubMed, Scopus and Cochrane, were screened, from inception to 29 October 2023, taking into consideration the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. All the inclusion criteria were met by eight studies. The total operative time was around two hours in most studies, while the warm ischemia time was <30 min in all studies and <20 min in four studies. Positive surgical margins, conversion and transfusion rates ranged from 0% to 6.3%, from 0% to 5.0% and from 0.7% to 7.5%, respectively. Finally, the majority of the complications were classified as Grade I-II, according to the Clavien–Dindo Classification System. The MAP score is a useful tool for predicting not only the presence of APF during laparoscopic PNs but also various intraoperative and postoperative characteristics. It was found to be significantly associated with an increased operative time, estimated blood loss and intraoperative and postoperative complication rates.
A Phase Ib Expansion Cohort Evaluating Aurora A Kinase Inhibitor Alisertib and Dual TORC1/2 Inhibitor Sapanisertib in Patients with Advanced Solid Tumors
Authors: Davis S. Lindsey , Messersmith Wells A. , Purcell W. Thomas , Lam Elaine T. , Corr Bradley R. , Leal Alexis D. , Lieu Christopher H. , O’Bryant Cindy L. , Smoots Stephen G. , Dus Evan D. , Jordan Kimberly R. , Serkova Natalie J. , Pitts Todd M. , Diamond Jennifer R.
Published: April 2024

Background: This study further evaluated the safety and efficacy of the combination of alisertib and sapanisertib in an expansion cohort of patients, including a subset of patients with refractory pancreatic adenocarcinoma, with further evaluation of the pharmacodynamic characteristics of combination therapy. Methods: Twenty patients with refractory solid tumors and 11 patients with pancreatic adenocarcinoma were treated at the recommended phase 2 dose of alisertib and sapanisertib. Adverse events and disease response were assessed. Patients in the expansion cohort were treated with a 7-day lead-in of either alisertib or sapanisertib prior to combination therapy, with tumor tissue biopsy and serial functional imaging performed for correlative analysis. Results: Toxicity across treatment groups was overall similar to prior studies. One partial response to treatment was observed in a patient with ER positive breast cancer, and a patient with pancreatic cancer experienced prolonged stable disease. In an additional cohort of pancreatic cancer patients, treatment response was modest. Correlative analysis revealed variability in markers of apoptosis and immune cell infiltrate according to lead-in therapy and response. Conclusions: Dual targeting of Aurora A kinase and mTOR resulted in marginal clinical benefit in a population of patients with refractory solid tumors, including pancreatic adenocarcinoma, though individual patients experienced significant response to therapy. Correlatives indicate apoptotic response and tumor immune cell infiltrate may affect clinical outcomes.
Versatile Polyoxometalates of Different Structural Dimensionalities for Liquid Phase Catalytic Oxidation
Authors: Neves Patrícia , Simões Guilherme , Napruszewska Bogna D. , Pamin Katarzyna , Serda Paweł , Łasocha Wieslaw , Valente Anabela A.
Published: April 2024

Ionic polymolybdate compounds (IPOM) possessing the anions [Mo8O26]4− and [Mo3O10]2−, and cyclohexylammonium (Cy6N) or anilinium (Anil) as organic cations, namely cyclohexylammonium β-octamolybdate dihydrate (1), cyclohexylammonium trimolybdate hydrate (2), anilinium β-octamolybdate dihydrate (3), anilinium trimolybdate tetrahydrate (4) and anilinium trimolybdate dihydrate (5), were synthesized via simple, eco-friendly one-pot routes. New crystal structures of 1, 2 and 5 were discovered. IPOM compounds with different structural dimensionality, density and ratio of the number of terminal oxo groups/molybdenum atoms (n(oxo)/Mo) were developed. The IPOM compounds promoted the epoxidation of biobased olefins such as the fatty acid methyl esters methyl oleate and methyl linoleate with tert-butylhydroperoxide as oxidant, leading to conversions of at least 81% at 4 h, 70 °C and the corresponding epoxides. The reaction scope of applications for the IPOM catalysts covered cyclooctane oxidation.