bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the extranucleolar ribonucleoprotein particles of Cycas revoluta Thunb. (Cycadaceae) and Ceratozamia mexicana Brongn. (Zamiaceae)
Authors: Agredano-Moreno Lourdes-Teresa , Segura-Valdez María de Lourdes , Jiménez-Ramírez Jaime , Jiménez-García Luis-Felipe
Published: April 2022

Background: Nuclear ribonucleoprotein particles play a key role in RNA processing and in the gene expression pathway. Interchromatin granules (GICs) involved in the metabolism of pre-messenger RNA (pre-mRNA) were described in Allium cepa and Chiranthodendron pentadactylon . Other particles as Lacandonia granules (LGs) were found in Lacandonia schismatica as well as Ginkgo biloba and Welwitschia mirabilis . LGs are structures equivalent to perichromatin granules (PCGs) described in mammals and to Balbiani ring granules (BRGs) described in the midge Chironomus tentans . PCGs and BRGs are involved in the metabolism of messenger RNA (mRNA). Here, we analyze the extranucleolar particles from Cycas revoluta and Ceratozamia mexicana and compare them to GICs and LGs using conventional electron microscopy and atomic force microscopy.
Species study: Cycas revoluta (Cycadaceae) and Ceratozamia mexicana (Zamiaceae)
Hypothesis: The extranucleolar ribonucleoprotein particles in the nuclei of C. revoluta and C. mexicana are equivalent to GICs or GLs.
Methods: Fragments of young leaves of C. revoluta and C. mexicana were processed for standard transmission electron microscopy. Thin sections were stained with the EDTA technique preferential for ribonucleoproteins and osmium amine specific for DNA. From the semithin sections the samples were studied with the AFM and images of them were obtained.
Results: Ribonucleoprotein particles 32 nm in diameter are present in the interchromatin and perichromatin space in C. revoluta and C. mexicana .
Conclusion: Ribonucleoprotein particles present in the cell nuclei of C. mexicana and C. revoluta are ultrastructurally equivalent to LGs .

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Exploring autophagy related prognostic genes of Alzheimer's disease based on pathway crosstalk analysis
Authors: Qian Fang , Kong Wei , Wang Shuaiqun
Published: April 2022

Recent studies have shown that different signaling pathways are involved in the pathogenesis of Alzheimer's disease (AD), with complex molecular connections existing between these pathways. Autophagy is crucial for the degradation and production of pathogenic proteins in AD, and it shows link with other AD-related pathways. However, current methods for identifying potential therapeutic targets for AD are primarily based on single-gene analysis or a single signal pathway, both of which are somewhat limited. Finding other methods is necessary for providing novel underlying AD therapeutic targets. Therefore, given the central role of autophagy in AD and its interplay with its pathways, we aimed to identify prognostic genes related to autophagy within and between these pathways based on pathway crosstalk analysis. The method of pathway analysis based on global influence (PAGI) was applied to find the feature mRNAs involved in the crosstalk between autophagy and other AD-related pathways. Subsequently, the weighted gene co-expression network analysis (WGCNA) was used to construct a co-expression module of feature mRNAs and differential lncRNAs. Finally, based on 2 autophagy-related crosstalk genes (CD40 and SMAD7), we constructed a prognosis model by multivariate Cox regression, which could predict the overall survival of AD patients with medium-to-high accuracy. In conclusion, we provided an effective method for extracting autophagy-related significant genes based on pathway crosstalk in AD. We found the biomarkers valuable to the AD prognosis, which may also play an essential role in the development and treatment of AD.
[RETRACTED] Lights Out CBD Gummies Reviews (Scam or Legit?)How Much Safe Lights Out CBD + CBN Gummies Are Check Here? v1
Authors: Out CBD Gummies Lights
Published: April 2022

[RETRACTED]

Lights Out CBD Gummies Reviews (Scam or Legit?)How Much Safe Lights Out CBD + CBN Gummies Are Check Here?
[RETRACTED] Lights Out CBD Gummies | Definitely You'll Love The WAY It Works! Is It Legitimate Or Scam? v1
Authors: Out CBD Gummies Lights
Published: April 2022

[RETRACTED]

Lights Out CBD Gummies | Definitely You'll Love The WAY It Works! Is It Legitimate Or Scam?
[RETRACTED] EAGLE HEMP CBD GUMMIES REVIEWS: [PROS & CONS] RISKY USER COMPLAINTS 2022? v1
Authors: not provided Anthonyparsone
Published: April 2022

[RETRACTED]

Eagle CBD Gummies is a extraordinary CBD product this is synthetic with the purest and terrific CBD to remove pressure, insomnia, persistent frame ache, cancer, smoking dependancy, cardiovascular fitness problems, and diverse different fitness problems.
[RETRACTED] Lights Out CBD Gummies v1
Authors: not provided lightsoutcbd
Published: April 2022

[RETRACTED]

Lights Out CBD Gummies come in a single package with 750mg of hemp and 300mg of CBN per container of 30 gummies. As a result, they can provide CBD that is both full-spectrum and conventional. THC
La estetización discursiva del cuerpo femenino en la fotografía de Francesca Woodman
Authors: Casado Chamizo Sergio
Published: April 2022

Desde que la fotografía de Francesca Woodman comenzó a ocupar el interés de algunas personas dedicadas al ámbito de la Estética y de la Teoría de las Artes hace pocas décadas, muchos han sido los conceptos y temas filosóficos que se han estudiado a partir del propio análisis que la artista lleva a cabo en su obra. En este estudio nos adentramos a analizar la categoría de “cuerpo femenino”, present en la mayoría de las instantáneas de Woodman, a la par que iremos dilucidando todo el entramado teórico que la artista busca presentar en su obra como aquellos elementos que atraviesan la mirada social de este determinado cuerpo a partir de una introducción a la semiología. Con ello, podremos dar cuenta de cómo un conjunto de resortes interdisciplinares encuentra en determinadas propuestas epistemológicas y estéticas modernas un punto de proyección hacia ese interés tan marcado, casi convirtiéndose en un fetiche, como es el estudio y determinación filosófica, epistemológica y artística del cuerpo femenino. Finalmente, propondremos tomar esto desde lo sublime kantiano para entender cómo esta fotografía juega en un sentido dialéctico y crítico con todo ese entramado onto-lógico de base y descubrir las propuestas que desde una determinada propuesta puede realizar estética.
Diagnosis and Treatment of Cutaneous Aspergillosis
Authors: Park Kyung Duck
Published: April 2022

Aspergillosis is an opportunistic mycosis caused by fungi in the genus Aspergillus, mostly A. fumigatus and A. flavus.
Typical entry portals in primary cutaneous aspergillosis include burns, trauma sites, surgical wounds, intravenous
catheters, and macerated skin in underlying occlusive dressings. In individuals who are immunocompromised, the
dissemination risk is significant. Skin findings range from firm papules and necrotic papulonodules to hemorrhagic
bullae and ulcers. The prognosis is poor but improves when the patient is no longer neutropenic or when
corticosteroids are discontinued. Localized primary cutaneous aspergillosis can be excised surgically, followed by
oral antifungal administration. For the first-line treatment of pulmonary invasive aspergillosis, isavuconazole and
voriconazole are the preferred agents, whereas liposomal amphotericin B is supported moderately.
Coronavirus Disease 2019-Associated Pulmonary
Aspergillosis
Authors: Hwang Young Hoon , Park Wan Beom
Published: April 2022

As the coronavirus disease 2019 (COVID-19) pandemic continues, a new disease, COVID-19-associated pulmonary
aspergillosis (CAPA), is on the rise. CAPA is a secondary fungal infection in patients with critical COVID-19 receiving
mechanical ventilation in intensive care units (ICUs). Although the incidence rate of CAPA is estimated to be 10.2%
in ICU patients, CAPA appears to be associated with an increase in overall mortality. CAPA is like classical invasive
pulmonary aspergillosis (IPA) but has an ambiguous clinical manifestation and occurs without typical host factors.
It is also like influenza-associated pulmonary aspergillosis but differs in clinical characteristics. For research and
clinical practice, the European Confederation for Medical Mycology and the International Society for Human and
Animal Mycology proposed novel case definition criteria for CAPA. Although CAPA management is not much
different from typical IPA, areas of uncertainty remain that require further investigation.
A Case of Superficial Fungal Infection caused by
Naganishia diffluens
Authors: Kim Taekwoon , Choi Yongwoo , Choi Jong Soo , Park Joonsoo
Published: April 2022

Most superficial fungal infections of the skin are caused due to dermatophytosis or yeasts. However, it is rare for
Cryptococcus species to cause infections. Among the fungal infections by Cryptotoccus species, Cryptococcus
(C.) neoformans and C. gattii are the most common pathogenic species. However, other rare infections have been
reported. Subcutaneous cryptococcosis due to Naganishia (N.) diffluens (formerly Cryptococcus diffluens) was
first reported in Turkey. We present the case of a 53-year-old man who had mild pruritic annular, erythematous,
scaly patches with inner small, crusted papules and nodules on both axilla and trunk for 3 months. A potassium
hydroxide test on his abdomen scales was positive. Fungal culture, light microscopic findings, and the sequencing
of an internal transcribed spacer of rRNA gene confirmed the presence of N. diffluens. As a result we diagnosed the
patient with a superficial fungal infection caused by N. diffluens and treated it successfully with oral itraconazole
and topical isoconazole.
A preliminary comparison of two different polyacrylamide hydrogel fabrication methods demonstrate differences in stiffness measurements and adhesion abilities of osteosarcoma cells
Authors: Luu Anita , Macdonald Rachel , Parg Richard , Dutcher John , Petit Alicia
Published: April 2022

The purpose of this research was to compare two different polyacrylamide hydrogel fabrication methods described in the literature and assess their use in mechanotransduction studies in osteosarcoma. Both methods employ succinimide chemistry to functionalize the hydrogel surface for cell response studies, one in the form of NHS, while the other in the form of Sulfo-SANPAH. Six hydrogels of two different stiffness were created for each method and were evaluated on their receptiveness to cell seeding and Young’s moduli with atomic force microscopy. Both hydrogel fabrication methods lack reproducibility as significant differences were observed in stiffness measurements between six hydrogels at both 0.5 kPa and 50 kPa stiffnesses. Despite the Sulfo- SANPAH method of preparation being more receptive to cell seeding and generating the expected effects on known mechanotransducers, it appeared to have larger variabilities in stiffness measurements for both 0.5 kPa and 50 kPa prepared hydrogels. Researchers may employ the Sulfo-SANPAH method to study the impact of ECM of varying stiffness on osteosarcoma cell mechanotransduction, but should remain cautious when interpreting results as a function of the expected stiffness. Studies should be accompanied by measurements of Young's modulus whenever possible.
The cognitive basis of psychosocial impact in COVID-19 pandemic. Does it encircle the default mode network of the brain? A pragmatic proposal.
Authors: Dubey Souvik , Dubey Mahua , Ghosh Ritwik , Mitchell Alex , Chatterjee Subhankar , Das Shambaditya , Pandit Alak , Ray Biman , Das Gautam , León Julián
Published: April 2022

Epigenetics, hypothalamic-pituitary axes, environmental and metabolic influences, and transgenerational plasticity govern social behavior. Cognitive research considers the brain's default mode network (DMN) as a central hub that integrates various cognitive and social processing domains responsible for emotion perception, empathy, theory of mind, and morality. Hence, DMN is regarded as the "social brain." Upsurge in social turmoil, social anxiety, panic, depression, post-traumatic stress, hoarding, herd behavior, substance and behavioral addictions, sexual abuse, and violence in the time of the COVID-19 pandemic are intricately related to personality traits resulting in disruptive social cognition and social behavior, conceptualized as the result of unsettling and disruption of the functional nexus of the DMN. Considering overt and conspicuous display of neuroticism during the current pandemic, its impact upon modulation of the DMN functional nexus and the DMN itself, and the potential to presage cognitive impairment in the future, the authors caution that an increase in the global burden of dementia may be one of the long-term ramifications of COVID-19. Social behavior, a functional derivative of the DMN, can strikingly affect the functional nexus of DMN and the DMN itself, in a centripetal way via the phenomenon called "Experience-Dependent Plasticity," with long-term consequences. In this review, we intend to 1) decipher the association between social cognition and social behavior with the DMN, in time of COVID-19; and to 2) discuss the prospective aftermath of disrupted social behavior during the pandemic on modulation/alteration of functional connectomes of DMN or the DMN itself in the time ahead.
The Role of Counter-Anions on Cationic Antimicrobial Agents
Authors: Lee Cheol , Kim Hyun , Timilsina Shreya , Priefer Ronny
Published: April 2022

Even though a myriad of antimicrobial agents have been developed over the decades, resistant mechanisms continually break through, ultimately increasing our mortality and fears. Significant efforts have been made to evade these pathogenic resistances by developing novel antimicrobial agents which work on different targets. One possible, simple solution that has also been investigated has been to modify the counter-anion of cationic-based drugs. Although a multitude of studies have evaluated the efficacy of the active cationic agent, some have also explored the often-neglected influence of the counter-anion. Understanding the role of the counter-anions may provide new antimicrobial agents and an alternative approach to quell antimicrobial resistance. This review focuses on the various studies that have either directly or in-directly evaluated the role of the counter-anion on antimicrobial activities. Indeed, certain cationic-based agents display significant alternation in their activity when paired with the correct anion.
Biologic Knee Arthroplasty in 360 Degrees for Early Osteoarthritis Treatment
Authors: Gobbi Alberto , Morales Macarena , Valsecchi Giacomo
Published: April 2022

This article gives a comprehensive review of a two-step single surgical alternative that searches to preserve the patient's cartilage and joint. It addresses the knee from a 360-degree perspective; First, from the articular side, full-thickness cartilage lesions are treated with hyaluronic acid (HA) scaffold combined with bone marrow aspirate concentrate (BMC), which restores the articular cartilage with a hyaline-like tissue. Then, deep inside the subchondral bone, a minimally invasive procedure called Osteo-Core-Plasty (OCP) is conducted when it is affected. This procedure serves to restore the subchondral bone with structural bone autograft and BMAC derived signaling cells. The HA-BMC cartilage preserving technique with more than ten years of follow-up provides persistent and prothesis sparing surgical results, while OCP offers the further benefits of the new technology for deep joint bone-core treatment and regeneration with significant improvement in clinical score outcomes and magnetic resonance imaging. Given the evidence, these articular preservation techniques can be considered the new paradigm knee arthroplasty surgery as they can achieve a valuable and holistic approach to early osteoarthritis treatment.
Suspected transthyretin cardiac amyloidosis by cardiac scintigraphy in heart failure with preserved ejection fraction, left ventricular hypertrophy and red flag manifestations
Authors: Llobera Mariano , Marquez Lilia , Kostiw Kari , Webster Dave , Vitali Atilio
Published: April 2022

Background Transthyretin Cardiac Amyloidosis (ATTR) is a type of restrictive cardiomyopathy, which typically manifests as Heart Failure with Preserved Ejection Fraction (HFpEF). The presence of unexplained left ventricular hypertrophy (LVH) associated with HF and red flag manifestations could increase the diagnostic probability. However, the diagnostic prevalence of this triad by cardiac scintigraphy remains uncertain. Methods From August 1st to December 31st, 2021, 22 consecutive patients diagnosed with a HF (ejection fraction more than 40%), LVH with unexplained etiology and at least one red flag clinical manifestation, underwent pyrophosphate scintigraphy (99mTc-PYP). The patients were divided into two groups: “Positive” and “Negative” (as defined by grade 2 or 3 uptake). Multiple logistic models were made with variable 99mTC-PYP and explanatory variables. Results Among 22 patients, 15 had a positive 99mTc-PYP study for ATTR. The prevalence of ATTR using the triad of HFpEF, unexplained LVH and at least one red flag was 68% (CI 95%; 45-86%). Patients with 99mTc-PYP positive tended to be male, older, and with an aortic mean gradient and interventricular septum higher, as compared to the group with a negative study. The most frequent red flag clinical manifestations were proteinuria (55%) and pseudoinfarction pattern (55%). The presence of 2 or more red flags could increase the diagnostic probability of the test (OR 1.6 (CI95% 0.52-4.89). Conclusions The diagnostic probability of ATTR by 99mTc-PYP scan could increased when a clinical manifestation of a red flag was added to the suspected diagnosis of heart failure and left ventricular hypertrophy. The use of non-invasive techniques allows early identification and treatment of this underdiagnosed disease.
Intranasal Chlorpheniramine Maleate for the treatment of COVID-19: Translational and Clinical Evidence
Authors: Sanchez-Gonzalez Marcos , Westover Jonna , Rizvi Syed , Torres Joselit , Ferrer Gustavo
Published: April 2022

Recently, the nasal cavity has been highlighted as an ideal route of administration for interventions as it is the portal of entry of the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The present study aimed to demonstrate the feasibility and efficacy of intranasally administered Chlorpheniramine Maleate (CPM) spray to treat coronavirus disease 2019 (COVID-19). Methods: The present study used a two-phase, non-clinical to clinical approach. The non-clinical phase evaluated CPM’s antiviral activity against SARS-CoV-2 delta (B.1.617.2) strain via a highly differentiated three-dimensional in vitro model of normal, human-derived tracheal/bronchial epithelial cells. CPM was tested in duplicate inserts of the tissue models of the human airway. Virus yield reduction assays measured antiviral activity on day six after infection. For the clinical phase, COVID-19 symptomatic (polymerase chain reaction positive) patients were recruited and assigned to a 7-day CPM treatment (n=32) or placebo (PLB; n=13). Close safety monitoring of all patients was conducted before and after administering the drug. The primary outcomes monitored were time to symptom resolution (days), progression to hospitalization, emergency room visits, and symptoms of the severity of the disease using a visual analog scale (VAS) on a scale of 1-10 (no symptoms to worst symptoms). Results: The virus yielded a reduction in the assay such that the CPM solution log reduction value was 2.69 and Remdesivir 0.12, demonstrating much high antiviral activity of CPM. Results of the clinical phase demonstrate that VAS scores between the groups were evident after using CPM for two days (day 3). The CPM group VAS were significantly lower (P<0.001) starting from day three compared with day one. In contrast, there were no statistically significant (P>0.05) changes in the PLB during the 7-day treatment window. No subjects in the intervention group were hospitalized, while two in the PLB required hospitalization (15.4%; X2=5.15, P=0.023). Besides some mild discomfort felt by subjects immediately after applying the spray, the participants reported neither adverse reactions nor side effects. Conclusion: If taken together, the results of the present two-phase study point towards the conclusion that CPM is an antiviral agent that can be administered intranasally to treat COVID-19 effectively.
Review study on epileptiform discharge during sleep and circadian rhythm modulation during seizures
Authors: Srinivas Sujithra
Published: April 2022

Epilepsy is a neurological condition that affects approximately more than 50 million people around the globe, out of which the prevalence of this disease is also seen in developed countries. Epilepsy can be clinical defined by two or more non triggered seizures. A seizure can be characterized as a paroxysmal event which is caused due to hyper–synchronization in the neurons that many have various reasons of manifestation. The neuronal discharge maybe focal spreading in specific brain cortex or widespread throughout the cortex. An Electroencephalogram (EEG) is used to in diagnosis and management of epilepsy and can be used for routine examinations, it also considered to be the golden standard investigation of epileptic syndrome. While using EEG the distribution, presence and frequency of interictal epileptiform discharges IEDs are suggestive diagnosis of epilepsy. In other words the presence of IEDs in an individual’s EEG is a diagnosis of epilepsy. IEDs are predominantly found in EEG that is performed during sleep which can give basic diagnosis and prognosis of sleep related epilepsies in patients. During sleep latent interictal discharge are activated. Sleep IEDs are said to greatly affect the epilepsy management. These interaction mechanisms of sleep and epilepsies tends to bring about changes in behaviour of the seizure.
Olfactory neuroblastoma: A case report
Authors: Kathuria Sunil , Sunny Chikku
Published: April 2022

Olfactory neuroblastoma (ON) is a rare malignant neuroectodermal tumor of the nasal cavity. The malignancy accounts for <3% of tumours originating in the nasal cavity. Through the nasal cavity, ON may infiltrate the sinuses, the orbit and the cranium. The tumour is characterized by a pattern of slow growth and local recurrences. Olfactory neuroblastoma is a neoplasm that can histologically mimic many tumours within the sinonasal tract. Treatment options are surgical excision combined with a radiotherapy and/or chemotherapy combination treatment.

The present study reports the case of a 45 year-old male patient with a mass in the nasal cavity who was treated by combined surgical excision and radiotherapy. The literature for ON and the treatment of the tumour are also discussed.
Docência Online: Percepções de Estudantes Stricto Sensu em Tempo de Pandemia
Authors: Fontolan Maria Vitoria , Peres Katiucia de Oliveira , Soares Simone Cesario , Ahlert Alvori
Published: April 2022

A pandemia mundial da COVID-19 impôs novos desafios para docentese estudantes com a mudança da educação presencial para a educação à distância,ou remoto-síncrona. O objetivo geral da pesquisa foi verificar como estasmudanças afetaram, especificamente, a pós-graduação stricto sensu daUniversidade Estadual do Oeste do Paraná/ Brasil. Para isso, foi usada ametodologia descritiva, com análise quanti-qualitativa, para compreender e refletiracerca das principais mudanças nas práticas docentes e métodos de ensino-aprendizagem. Os resultados evidenciaram que, na percepção dos/as estudantes, obom/boa professor/a é aquele/a que valoriza os aspectos profissionais erelacionais, que fomenta a discussão e a pesquisa, envolvendo os/as estudantes noprocesso, por meio de atividades interdisciplinares relacionadas com a atualidadee na resolução de dúvidas, assim como a adaptação do/a docente com o modo remoto-síncrono. Conclui-se que, na compreensão dos/as estudantes, há qualidadede ensino nas aulas e na pesquisa interdisciplinar do ensino superior, e que estasmudanças paradigmáticas demandam profissionais comprometidos/as, flexíveis ecompreensivos/as, com competência científica, pedagógica e didática também pormeio das tecnologias.
Palavras-chave: Educação. Ensino-superior. Aulas-síncronas. Pandemia.
ELEMENTS OF THE LANGUAGE CODE IN THE POETICS OF GUZEL YAKHINA’S NOVEL "ZULEIKHA OPENS HER EYES"
Authors: DOLGOV Veaceslav G.
Published: April 2022

The initial thesis of the research presented in this article is the statement about the significance of the Slavic pagan mentality, elements of the pagan worldview and folk demonology in the poetics of Guzel Yakhina's novel “Zuleikha Opens Her Eyes”. The analysis reveals the levels of poetics specifying the elements of the pagan code, presenting their content and determining their artistic role. In the course of the analysis, the levels of poetics were revealed, at which elements of the pagan code were found, their content was presented, and the artistic role was determined. The largest number of pagan conversions, according to our observations, is found in the first part and the first section of the second part of the novel, in which the usual life of the heroine is presented. The most important mythologemes of the novel are “river” and “forest”. To characterize the heroes, the author uses natural images, in particular zoonyms. The most representative in this respect is the image of Grunya, whose physical and physiological characteristics are described by establishing connections with a bear and a horse. In the poetics of Guzel Yakhina's novel, the degree of significance of the pagan worldview is high: the elements of the pagan code have a wide variety of artistic functions at the levels of the character system, plot construction, ideological and thematic originality, pictorial and expressive means.
RUSSIAN AND UKRAINIAN LAYERS OF THE SURNAME ANTHROPONYMICON OF THE CITY OF VYLKOVE, ODESA REGION
Authors: VDOVICHENKO Nataliya V.
Published: April 2022

The purpose of the article is to analyze the volume, structure and semantics of the motivating bases of Russian and Ukrainian surnames that belong to the residents of Vylkove, Odesa region. The object of the study is surname anthroponyms.The method of linguistic analysis is used in the work, which includes descriptive method and methodof comparative and statistical analysis. The results of the analysis allow us to state that the semantic identity of the structural composition of Russian and Ukrainian surnames differs significantly: Ukrainian surnames are more diverse. The author concludes that in the city of Vylkove, which was founded in the 18th century by Nekrasov Old Believers, joined by the Zaporozhian Cossacks, and which is historically bilingual, Russian surnames predominate, followed by Ukrainian ones. It is specified that Ukrainian and Russian surnames have much in common: most of them are patronymic in the semantics of their motivating bases because they indicate the naming of a son by the name, occupation, origin, physical and mental characteristics of the father. However, Ukrainian surnames use more diverse forms than Russian ones.The surname an throponymy of the city made it possible to observe the geographical factor in its settlement by Ukrainians, mainly from the Naddnipryanshchyna region, Poltava region, Zaporizhzhia region, Volyn region and Western Polissya. In Vylkove there is a significant layer of Ukrainianized Polish surnames, while Russian surnames are quite compact and do not show any special territorial features. It is significant that the vast majority of Russian surnames are traditional, created in the initial period of their formation and to some extent reflect the traditional way of life and worldview of the Old Believers — the founders of this village
LINGUISTIC HALO OF BEAUTY THAT WILL SAVE THE WORLD
Authors: DIADECHKO Liudmyla P.
Published: April 2022

The purpose of the article is to determine the linguistic status of the expression Beauty will save the world and the degree of its attribution to F. Dostoyevsky in Russian. The object of the analysis is the prototypes of the winged expression Beauty will save the world and the way the expression functions in fiction and journalistic texts. The subject matter of the study is structural and semantic peculiarities of the expression and their evolution in the process of its eptonymization. The paper employs the methods of source studies and contextual analysis, historical and descriptive methods, the method of questionnaire and double applique. The results of the research prove that the expression Beauty will save the world shows signs of eptonymization. The study gives a wide linguistic and historical background to the constituents and structure of the expression Beauty will save the world and its fate in the language. Conclusions. There is only semantic similarity between the aphoristic expression originating from the novel The Idiot and its prototypes, which proves the authorship of the expression attributed to Dostoyevsky. The stereotypical idea of the text of the novel The Idiot, which has become part of the Russian linguaculture, underlies the semantics of the expression functioning in contemporary contexts as an eptonym. The aphoristic expression has developed two meanings: one linked to the interpretation of beauty as a spiritual matter, the other related to its outer manifestations. The linguistic status of the expression is proven by its multiple modifications in speech and its phrase-formation capacity. Another expression has originated from it; an expression modified by the artist N. Roerich. Practical value of the findings is their application in strengthening the suggestive potential of speech; compiling general and special dictionaries of eptonyms, quotations, aphoristic expressions; for educational purposes, as well as for fundamental research of the evolution of phraseological language system.
NEUROETICS AND NEUROLINGUISTICS IN CONTEMPORARY LINGUISTICS
Authors: TRUBA Hanna M.
Published: April 2022

The article reflects the history of the formation and development of the term Neuroethics in modern scientific opinion. Relevance: at the present stage of development of scientific thought, neurosciences acquire relevance and take their acting place among others. Yes, deep research into neuroscience issues has not spared philology either. Under the influence of modern research, issues of such scientific disciplines as Affective Neurobiology, Computational, Neurochemistry, Neurophysiology are especially relevant and illuminated in a new way. Neuro engineering, Neuroanatomy, Neuroetology, Neuroimmunology, Neuroinformatics, Paleoneurobiology, neuroeconomics, Cognitive science, Neurolinguistics, Social Neurobiology, Cognitive Neurobiology, Cultural Neuropsychology, Neuroethics. Cognitive Science, Cognitive Science, Neurolinguistics, Social Neurobiology, Cognitive Neuropsychology, Social Cognitive Neurobiology, Neuropsychologists. More and more they delve into the processes of thinking, thought of correction, thought of suggestion of a person, and, therefore, the issue of ethics and the limits of this intervention is relevant. The aim of the article is to raise the question of the relevance of Neuroethical problems for linguistic disciplines. The object of the article is the study of issues of Neuroethics, and the subject is the possibility of applying the basic principles of Neuroethics to modern linguistic disciplines.
THE MOST EFFECTIVE DECISIONS OF LANGUAGE ANXIETY PROBLEM
Authors: NEGLYAD Tatiana Yu.
Published: April 2022

This article is about language anxiety as a problem, that exist in foreign languages learning. The purpose of the article is to study the most effective approach to overcoming this problem. The object of this analysis are the main methods of teaching oral communication skills. The subjects of this study are different types of English formulaic language as examples. As a result, three main methods, that are effective to overcoming this problem, were found: 1) psychological method, 2) formulaic language method, 3) visual support method. Conclusions: the problem of language anxiety is definitely linguistic, because the formulaic language method can be called the most effective to overcoming this problem. Also, the finding of the research is, that the most useful exercises to overcoming language anxiety are playing exercises, what unite the all three methods. The article can be useful for teachers of foreign languages (for example, English), who wish to get the results in teaching oral communication among students, because all listed abovemethods and exercises can be used effectively in teaching practice.
FEATURES OF CREATING A GERMAN ANECDOTE IN THE LINGUISTIC ASPECT
Authors: PAZINA Svitlana V.
Published: April 2022

The purpose of the article is to investigate the characteristic lexical means (linguistic features) of German jokes based on literary material and to determine the principles that apply to the creation of German jokes in the texts considered. The object of research in this work is an anecdote as an element of German culture, folklore, language, literature. In view of the small volume of the article, we have considered only the anecdotes of the German origin (without anecdotes of other countries about the Germans). The subject of the study is the lexical composition, the linguistic features of the German joke. We have thrown light upon the provisions that formed the basis of practical research. The author considers the lexical tools used to create a German anecdote and reinforces the results with tables with data from frequency lists. The result of the study: 1) the structure and distribution of lexical units in the text of German anecdotes were investigated; 2) the lexical composition of the selected anecdotes was perused; 3) the originality of lexical units used to create anecdotes was considered; 4) the functional features of the lexical units used to create studied German anecdotes are determined. Conclusions: Most German anecdotes are based on the principle of participation of contrasting persons (man — woman, adults (parents) — children, spouses — lovers, etc.); the most commonly used words in German anecdotes mean actions reflecting the dynamics (movement), activity, emotionality; German jokes are mostly dialogue. The practical application of the research results is the use of an anecdote as an element in the different studies of German culture, folklore, language, literature, linguistic education, psycholinguistics, linguoculturology.
CONFLICTS IN THE INTERNATIONAL SPACE: RELEVANT PROBLEMS OF INTERCULTURAL COMMUNICATION AND BUSINESS PROTOCOL
Authors: ASTASHENKOVA Dariia K.
Published: April 2022

The purpose of the article is to identify and analyze non-verbal factors of conflicts arising in the international space during the process of business communication between the representatives of different cultures. The object of research is the intercultural conflict communication. The subject of consideration is conflicts in the international space, which arise against the background of violations of the protocol and intercultural communication norms by the parties of the negotiation process. To determine the non-verbal factors of conflicts arising in the international space, were used a methodof collecting informationas well as a method of observation, analysis and description, which allowed to highlight how the conflict-generating factors affect the international political communication.The result of this articleis proved that the irrational use of the national-culture symbols, as well as the violations of protocol contributing to the conflicts in the international space.Conclusions. Due to the ongoing process of globalization and intensification of contacts between the representatives of the Ukraine at the international level, knowledge about the intercultural communication norms and business protocol rules has become the integral competences to achieve the goals set in the negotiation process. The lack of the above-mentioned competencesmay damage the Ukraine’s image in the international arena, can lead to misunderstandings in the process of meetings and, as a consequence, obtain a negative outcome of the negotiations. On the contrary, awareness of the norms of intercultural communication and business protocol provides the opportunity to avoid conflicts, clearly express intentions, as well as to understand the signals transmitted by the counter-partiesin the negotiation process.
SECONDARY NOMINATION AS A WAY OF CREATING POLISH LINGUISTICAL TERMINOLOGY
Authors: VOYTSEVA Olena A. , TOZHYIEVA Vitaliia V.
Published: April 2022

The aim of this article is to consider the process of secondary nomination in Polish linguistic terminology of Middle Polish (ХVI cen. — 80-th. XVIII cent.) and New Polish (80-th. XVIII cen. — begin. ХХ c.) periods, when did its originate and form. The objects of study are term units, which designate conceptions in the sphere of linguistics, which is fixed in lexicographical and methodological literature of Middle Polish and New Polish periods. The subjects of research are notable secondary nominations as universal dynamic term creative process in the system of linguistic terminology of the Polish language. Common science and special linguistic methods are used in the article. Thanks to induction and deduction, analysis, and synthesis we managed to make a theoretical conclusion systematization of fixed linguistic material. Describing and comparative methods are used for the explanation of the semantic construction of special lexemes, their origin, and functioning. Componential analysis is used for finding common components of term units meaning, which were created using secondary nomination. During the research, we got to the conclusion, that the most productive type of secondary nomination was terminologization. Among terminologizated lexemes, we isolate the names of grammatical categories, which formed the core of researched terminology and helped to form derivative nominations. The process of secondary nomination comes forward as a result of the development of a linguistical term system in the Polish language, caused by the realization of cognitive function of the language, generalization of science experience, and deepening of existing knowledge about linguistic notions. The perspective of the research are in comparative studying of semantic processes in linguistic terminologies of Polish and other Slavic languages.
TRENDS OF FORMATION AND TRANSFORMATION OF THE ONOMASTIC SYSTEM OF THE LANGUAGE (ON THE EXAMPLE OF OIKONYMS)
Authors: BONDARENKO Irina V. , KVASHA Tatyana G.
Published: April 2022

The purpose of the article is to study proper names and their functioning, analysis of extra-, intralinguistic factors caused by the specifics of the functioning of onyms in language and speech, ways to overcome the emerging omonyms, oikonyms. The object of the research is the toponyms of the language. The subject of the research is the oikonyms of the region as a specific toponymic system.To achieve the goal the authors used the following methods: analysis and synthesis, descriptive method, observation method, linguo-stylistic method. The research aspect of the article is realized like transformation processes in groups of proper names: a) change in the phonetic appearance and word-formation structure of onyms; b) de-etymologization (loss of internal form); c) resemantization (rethinking of the word). The authors analyzed the reasons for linguistic changes determined by both the internal laws of language development and extralinguistic tendencies, which made it possible to conclude the unity of divergent toponymic tendencies and convergent processes of the toponymic system itself, the purpose of which is to systematize different-structured and multilingual toponyms.
LINGUOCULTURAL FEATURES OF RUSSIAN AND CHINESE PHRASEOLOGICAL UNITS WITH PRAGMATONYMS
Authors: STEPANOV Ievgenii N. , MA Xinyue
Published: April 2022

The article describes Russian and Chinese phraseological units with key words — pragmatonyms — in linguocultural and applied aspects. The purpose of this work is to determine the mental national and cultural specificity of Russian and Chinese phraseological semiosis. This is based on the specifics of folk life, which the identified equivalent, background and non-equivalent phraseological units reflect. The key words of these phraseological units are the pragmatonyms of several LSG, naming food, clothing and footwear, household items: dishes, household utensils, household tools, haberdashery. Object of research is the Russian and Chinese phraseological units with Key words-pragmatonyms. Subject of study is reflection of Russian and Chinese national and cultural specifics through the prism of primordial pragmatonyms in the composition of folk phraseology. As a result of the study, it was concluded that pragmatonyms that become Key words in phraseological units, as a rule, symbolize a variety of values: social, spiritual, personal, religious, moral, and others. Among the analyzed phraseological units of the Russian and Chinese languages there is a small group of correlate phrases (equivalent phraseological units); much more often Russian and Chinese phraseological units similar in meaning have different lexical content, being background phrases (divergent phrases); a significant place is occupied by non-equivalent phraseological units, the selection of analogues for which in the compared language (for Russian phraseological units — in Chinese, for Chinese — in Russian) is difficult.
THE TEMPORAL ORDER CATEGORY IN THE FUNCTIONAL-SEMANTIC TEMPORALITY FIELD
Authors: FATEKH Halyna Ie.
Published: April 2022

The purpose of the article is to present the patterns of functioning of the temporal order category in the functional-semantic temporality field. The object of the study is language means that fix the movement of time in a real communicative process. The subject of this research is the ratio of grammatical and lexical indicators of the temporal order category, highlighted in the latest research in the field of functional linguistics. The material for the study is the text of A. P. Chekhov’s story “The Bride” (1903). In the process of studying, a descriptive method, methods of semantic, grammatical (morphological and syntactic) and functional analysis are used. As a result of the work carried out, the specificity of the category of temporal order was considered, which is well revealed when considered within the framework of the functional-semantic field of temporality. Conclusions. Temporal order is a functional-semantic text category, the implementation of which occurs in the structuring of the means of expressing temporality. It provides the dynamics of the action, process, state, being a kind of “engine” of the text in time terms under the influence of the given / new dichotomy. The specifiers of the category of temporal order, along with temporal relations and the expression of the exact / approximate dichotomy, additionally convey cause-and-effect relations that actualize the semantic attribute “the emergence of a new situation”, and some other relations. The temporal order category actively participates in the development of the storyline of the narrative.
Cyclization Reactions of Non-Conjugate Ynones with Propargyl Amine in the Presence of a Catalyst
Authors: TAŞDEMİR Volkan
Published: April 2022

In this study, acetate derivatives were obtained from the reaction of acetophenones using diethyl carbonate. The acidic proton of CH2 moiety was abstracted using a suitable base and α-propargyl-β-ketoester (non-conjugated ynone) derivatives 3a-c were obtained from the reaction of the acetate derivatives with propargyl bromide. By removing the ester group of α propargyl-β-ketoester derivatives under suitable conditions, α-propargyl acetophenones (non-conjugated ynone) 4a-c were obtained. In this study, 6 different unconjugated ynone derivatives were synthesized as starting material with yield in a range of 60-95%. Cyclization reactions with propargyl amine in the presence of three different unconjugated ynone derivatives, metal catalysts were investigated. The synthesis of propargyl pyrroles 7a-c having substituents on C-2 and C-5 was completed.
Self-development as a factor of professional growth of future teachers
Authors: Madina Zhilgildinova , Aubakirova Rakhila Zh , Manyapova Tina , Rakhmetollauly Berikbol Rakhat , Anatolyevna Kostyunina Alyona , Mishchenko Ekaterina Vitalevna
Published: April 2022

The problem of improving the professionalism of teaching staff for higher education is certainly important in the Kazakhstan education system. In modern conditions of constant changes in the content of education, the graduate model, the teacher must be ready for constant professional growth, freely orient in his profession and related fields of activity. The article is devoted to an important problem, the study of personal and professional self-development of a future teacher. The purpose of the study is to theoretically study aspects of self-development in the context of the professional growth of future teachers. The sample of respondents was 104 people. Data was collected using a questionnaire adapted from renowned researchers.  The article considers the factors of professional and personal self-development of teachers and reveals the possibilities of psychological support for the formation of a pedagogical position. Support is interpreted as assistance and support of a future teacher in the process of his professional and personal development.

Keywords: Competencies; professional development; personal self-development; self-development; stimulation.
Opinions of postgraduate students in Northern Cyprus towards distant education during COVID-19 pandemic
Authors: Üstün Aksoy Yeşim
Published: April 2022

In this research, the "case study" model was used to determine the views of university students in Northern Cyprus on distance education during the COVID-19 pandemic process. The population of this research consists of students studying in the districts of Nicosia, Famagusta, Girne and Lefke in Northern Cyprus. The study group was used as an easily accessible case sample and 20 students were studied in the study group. As a data collection tool in this study, a semi-structured interview form consisting of 6 open-ended questions was used, developed by the researchers regarding the views of higher education students in Northern Cyprus on distance education during the COVID-19 pandemic process. In the study, "content analysis" was used in the evaluation of the data. The collected data were organized within the framework of themes and concepts and presented in the findings. According to the results of the research, it has been determined that the online teaching of the courses during the pandemic process has various advantages and disadvantages that the students have some difficulties while using the online education system and some suggestions have been developed to make the system more useful by eliminating the disadvantages and difficulties.

 

Keywords: Online education, blended education, synchronous education, asynchronous education