bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Faktor Risiko dengan Kejadian Hipertensi di Wilayah Kerja Puskesmas Takalala Kecamatan Marioriwawo Kabupaten Soppeng
Authors: Musfirah Musfirah , Masriadi Masriadi
Published: September 2019

Hipertensi atau tekanan darah tinggi merupakan kondisi ketika seseorang mengalami kenaikan tekanan darah baik secara lambat atau mendadak. Menurut WHO penyakit tidak menulartelah menjadi penyebab kematian terbesardi dunia. disebutkan bahwa hampir 17 jutaorang meninggal lebih awal tiap tahunnyasebagai akibat epidemik penyakit tidak menular. Pada tahun 2025 nanti, angka ini kemungkinan akan meningkat menjadi 29,2%. Dari 972 juta penderita hipertensi, 639 juta berada di negara sedang berkembang, termasuk Indonesia dan  333 sisanya berada di negara majuJenis penelitian ini adalah jenis penelitian observasional dengan rancangan Case Control Study (studi kasus kontrol). Penelitian ini dilakukan di wilayah kerja Puskesmas Takalala Kabupaten Soppeng tahun 2018. Besar sampel yang digunakan dalam penelitian ini, kasus sebanyak 68 responden dan kontrol sebanyak 68 responden dengan menggunakan Case Control. Analisis data yang digunakan univariat, dan bivariat.Kesimpulan dari hasil penelitian ini yaitu riwayat keluarga 5,5 kali lebih besar berisiko Hipertensi di wilayah kerja Puskesmas Takalala Kabupaten Soppeng.Saran dari hasil penelitian ini yaitu masyarakat harus menerapkan pola hidup sehat, olahraga teratur minimal tiga kali minggu selama 30 menit setiap sesinya, tidak merokok atau minum alkohol, menghindari makanan tinggi garam dan lemak,  tidur cukup minimal 7 sampai 8 jam dalam hari, dan menghindari stres.
Symptoms, Diagnosis and Treatment of Hemangioblastoma Dissemination
Authors: Halim Michael
Published: September 2019

Haemangioblastomas present in nervous system are noticed to occur in correspondence with Hippel-Lindau diseases (VHL). With uncertain origins, Haemangioblastomas are tumours that does not poses any serious threats to an individual’s health but may become risky in various cases. There are various symptoms of this disease with easily approachable treatment methods. Some of the methods of treatments are mentioned in this report, namely; radiotherapy, Everolimus as systemic therapy, numerous types of chemotherapy suitable for this disease, resection surgery, microsurgical surgery, Bevacizumab treatment, and craniospinal radiation.

With the evaluation and examination of the HB (Haemangioblastomas) tumour it is considered that the occurrence of this specific tumour is still unidentified. In some cases it is considered that individuals having the hereditary disease of Hippel-Lindau (VHL) are affected with the existence of Haemangioblastomas. According to the researchers, HB tumour has the capability of occurring at any age, with differing symptoms. The symptoms usually appear or disappear according to their nature depending on the size and location of the Tumour. Referring 25 different researches and case studies, the researchers are unaware of the real reason of its occurrence, however the symptoms and location of this tumour are similar in most of the cases. Most of the common locations are known to be cerebellum and spinal cord. Within these researches, other case studies are involved that are referring the similar scenarios. A number of treatments are provided according to the nature and condition of each patient as conditions differ with reference to the nature of patients, as with reference to the case studies; most common patients residing are between the age of 40’s-70’s.

Keywords: Hemangioblastoma, Dissemination, VHL, Symptoms, Diagnosis, Treatments.
Vamos avanzando
Authors: Bazán Zurita Homero
Published: September 2019

Estamos en el año 2019 cumpliendo los 21 años de nuestra querida Casa Superior de Estudios Universitarios y este periodo nos encuentra en pleno proceso de licenciamiento, proceso que, desde la dación de la nueva ley universitaria 30220 en el 2014 y la creación de la Superintendencia Nacional de Educación Superior Universitaria (SUNEDU), se exige para todas las universidades del Perú, públicas y privadas.
Dengue Virus and Aedes Mosquitoes: Ecological Relationship
Authors: Shamsuzzaman AKM
Published: September 2019

Abstract Not Available

Journal of Current and Advance Medical Research July 2019;6(2):67-68
Comparison of Propranolol and Amitriptyline as Monotherapy for Migraine Prophylaxis
Authors: Islam Mohammad Ariful , Sultana Dahlia , Shahi Mohammad Selim , Hassan Mohammad Sayeed
Published: September 2019

Background: Several drugs are used individually for migraine prophylaxis.

Objective: The purpose of the present study was to compare the propranolol and amitriptyline as monotherapy for the prophylaxis of migraine.

Methodology: This randomized control trial was conducted in headache clinic at Banghabandhu Sheikh Medical University (BSMMU), Dhaka, Bangladesh from July 2012 to June 2014 for a period of two (02) years. Migraine patients with or without aura of 16 to 50 years of age, patients not on any prophylactic medication were included for this study. Patients meeting all the criteria was randomized group A who were treated with Amitriptyline and group B who were treated with propranolol. Patients was followed for a three months period during which they was instructed to maintain a headache diary. The primary outcome evaluated was the proportion of patients in each group that achieved a 50% reduction in the number of days with headache.

Result: A total 80 adult patients were selected. During 1st visit among the patients duration of pain 1 to 4 hours (2.5.0%), 5 to 8 hours (13.3%) 9 to 12 hours (35.0%) and above 13 hours (22.5%) in group A were recorded; however, in group B, duration of pain 1 to 4 hours 1(2.5), 5-8 hours 16(13.3%), 9-12 hours 19(47.5) and above 13 hours 4(10.0) (p>0.05). In group A, no adverse effect was found 26(65.0%), drowsiness 6 (15.0%), dryness of mouth 6(15.0%), constipation 2(5.0%), fatigue and bradycardia were not found. In group B, no adverse effect was found 29(72.5%), drowsiness, dryness of mouth and constipation were not found, fatigue and bradycardia were 7(17.5%) and 4(10.0%).

Conclusion: In conclusion number of attack and headache before treatment gradually decrease in subsequent follow up in both groups.

Journal of Current and Advance Medical Research 2019;6(2):77-82
Relationship of Haemoglobin and C Reactive Protein level with Different Types of Heart Failure Patients
Authors: Morshed Mahboob , Islam Md Joynul , Haseen Fariha , Haque Mohammad Ahtashamul , Amin ABM Ruhul
Published: September 2019

Background: Initial level of haemoglobin and CRP level is important issue among the different type of heart failure patients for their in-hospital outcomes.

Objective: The purpose of the present study was to see the relationship of haemoglobin (Hb) and CRP level with different types of heart failure patients.

Methodology: This cross-sectional study was conducted in the Department of Cardiology at Mymensingh Medical College, Mymensingh, Bangladesh from December 2010 to November 2011 for a period of two (2) years. Patients of ACS who were presented within 12 hours of chest pain were included as study population. Study population were categorized in four groups according to the level of hemoglobin and C-reactive protein. Blood sample was collected for baseline laboratory investigations like Troponin-I, random blood sugar (RBS), blood urea, serum creatinine, lipid profile, Hemoglobin and CRP level. Sample were then send to standard laboratory/Biochemistry department of MMCH.

Result: The mean age of the population was 52.18±8.88 years. Statistically non-significant mean age difference among the groups. Significant difference of mean left ventricular (LV) ejection fraction was found among the groups (p=0.005). Maximum patient in group 1 (48.5%) had ejection fraction in the range of 40 to 50%, compare to group 2(32.0%), group 3 (11.1%) and group 4 (5.8%). The heart failure was statistically significant in Killip class I (p=0.000) and Killip class II (p=0.000).

Conclusion: In conclusion haemoglobin and CRP level of acute coronary syndrome patients is statistically significantly associated with different types of heart failure

Journal of Current and Advance Medical Research 2019;6(2):101-105
PENGARUH KONSENTRASI GULA YANG BERBEDA DENGAN PENAMBAHAN KAYU MANIS (Cinnamomum burmannii) PADA MANISAN RUMPUT LAUT (Eucheuma cottonii) TERHADAP TINGKAT PENERIMAAN KONSUMEN
Authors: Nge Sonya Titin
Published: September 2019

Rumput laut merupakan tumbuhan laut yang mempunyai nilai ekonomis dan banyak pemanfaatannya. Pemanfaatan rumput laut sebagai sumber kesehatan dan gizi karna memiliki kandungan karbohidrat (gula atau vegetable gum), protein, sedikit lemak dan abu yang sebagian besar merupakan senyawa garam natrium dan kalium. Analisis proksimat dilakukan untuk mengetahui komponen utama dari suatu bahan makanan penelitian ini telah dilaksanakan pada bulan 18 September - 05 Oktober 2018 di lab biologi UKAW dan balai pengawas obat dan makan (BPOM) Kupang Nusa Tenggara Timur. Berdasarkan penelitian yang dilakuan maka hasil analisis organoleptik dari warna, aroma, tekstur dan rasa manisan rumput laut (Eucheuma cottonii) yang paling disukai panelis adalah pada perlakuan K3, kadar air pada perlakuan K3 yaitu 17,48%-18,34% dan kadar gula total yaitu pada perlakuan K3 = 25,09%. Hal ini disebabkan karna pemberian gula yang berbeda pada manisan rumput laut dengan penambahan kayu manis yang dapat mempengaruhi tingkat kesukaan, kadar air serta kadar gula total dari tingkat penerimaan konsumen pada manisan rumput laut tersebut.
A Comparative Parallel Study of Pharmacokinetics and Immunogenicity Following Single Intravenous Administration of Bevacizumab Biosimilar RPH-001 (Manufactured by R-Pharm Group, Russia) and Avastin® (Manufactured by F. Hoffmann-La Roche Ltd., Switzerland) in Healthy Male Volunteers
Authors: Kolganova M. A. , Bagaeva N. S. , Medvedev YuV. , Shohin I. E. , Demchinskaya A. V. , Palkina T. N. , Salazanov D. A. , Konopleva G. E. , Sheremeteva M. S. , Archuadze Sh. Z. , Lavrovsky Ya. V. , Savchenko A. Yu. , Samsonov M. Yu.
Published: September 2019

Introduction. Bevacizumab is a monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab is used as a targeted mono- or combination therapy for different solid tumors. Phase I clinical trial was performed to assess pharmacokinetics (PK) and immunogenicity of bevacizumab drugs. For this study 80 healthy male volunteers were recruited and randomized to either Avastin or RPH-001 group.

Aim. To assess and compare pharmacokinetics and immunogenicity (safety) following single intravenous administration of Avastin® (manufactured by F. Hoffmann-La Roche Ltd.,Switzerland) and bevacizumab biosimilar RPH-001 (manufactured by R-Pharm Group,Russia).

Materials and methods. Bevacizumab quantitation and quasi-quantitative anti-bevacizumab antibodies detection in human blood serum were carried out using photometric ELISA. Two different methods were successfully validated.

Results and discussion. Bevacizumab quantitation method was validated for selectivity and specificity, calibration curve, sensitivity, accuracy and precision, minimal required dilution, dilution linearity and stability. The anti-bevacizumab antibodies detection method was validated for cut-point (with normalization factor calculation), selectivity, sensitivity, precision, drug tolerance, dilution linearity, matrix effect (in case of serum hemolysis), and stability. The validated methods were successfully applied to pharmacokinetic and immunogenicity assessment of bevacizumab drugs. Conclusion. The results of the PK-study showed that test and reference bevacizumab drugs were equivalent. Immunogenicity study did not show any evidence of anti-bevacizumab antibodies in blood serum samples.
Study of Lercanidipine Drug Release from Medicine in Combination with Ramipril in vitro and in vivo
Authors: Shadrin A. A. , Ivkin D. Y. , Flisyuk E. V. , Smekhova I. E. , Plisko G. A. , Karpov A. A. , Semivelichenko E. D.
Published: September 2019

Introduction. Hypertension is the most common non-infectious disease in the world. New clinical recommendations for the diagnosis and management of patients with arterial hypertension are considering the issue of prescribing combination therapy and prefer fixed combinations of drugs in a single pill. The study of the pharmacokinetics of medicinal substances and the consideration of their pharmacokinetic parameters today is a necessary step in the complex of work, both in the creation of new original medicines and in the application of known generic drugs, and this is primarily due to obtaining objective characteristics of all processes occur in the body of the animal (human) with the drug. Pharmacokinetics is assessed in individual studies or as part of efficacy, safety, and tolerability studies.

Aim. The study of the release of lercanidipine from bilayer tablets containing two API (ramipril and lercanidipine) in the dissolution medium used for quality control in vitro and release in vivo, after oral administration of the drug to rabbits.

Materials and methods. Studies have been conducted on the release of lercanidipine from the combined drug in vitro and in vivo. As a test system were used laboratory rabbits Soviet chinchilla breed. Pharmacokinetic parameters were determined.

Results and discussion. A graph of the release of lercanidipine from the combined drug was constructed and the dependence of the concentration of this substance in the blood plasma of rabbits on time was revealed. Calculated pharmacokinetic parameters. An in vivo release study shows that the pharmacokinetics of lercanidipine are consistent with literature data.

Conclusion. The test drug has all the advantages of a rational fixed combination of antihypertensive drugs and simplifies therapy, meets the requirements of the latest clinical guidelines.
Actual Aspects of Medical Application of Black Nut – Juglans Nigra L. (Review)
Authors: Korochinsky A. V. , Daironas Ja. V. , Vernikovsky V. V. , Zilfikarov I. N. , Stepanova E. F. , Chernikov M. V.
Published: September 2019

Introduction. Herbal drugs of black walnut (Juglans nigra L.) are not registered on the territory of the Russian Federation at the present time. However, the State Register of Medicinal Products includes an extract of unripe fruits of a related species walnut (Juglans regia L.) «Yuglanex» (made in Russia) and the complex herbal drug «Tonsilgon» (made in Germany). A number of biologically active food supplements from black walnut raw materials have been registered by Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. They are an additional source of phenolic compounds as tannins and flavonoids. The purpose of the article is to study and systematize up-to-date information on the chemical composition of the medicinal plant raw material of black walnut and the pharmacological properties of its main biologically active compounds.

Text. All parts of the black walnut are used in the ethnomedicine of the indigenous population of North America according to indications similar to the walnut in Asia and the Manchurian nut in the Far East: snake bites, fever and disorders of the gastrointestinal tract.

The chemical composition of the medicinal plant raw material of black walnut is dencently walnut by its qualitative composition. Fruits, bark and leaves of black walnut contain a rich polyphenol complex (naphthoquinones, in particular, juglon and its derivatives, tannins, flavonoids, phenolic acids), vitamins, essential oil, organic acids. However, the quantitative analysis revealed a higher content of biologically active substances in the raw black walnut, especially in relation to polyphenolic compounds.

The scientific literature describes the results of experiments on animals, confirming antioxidant, antimicrobial, antifungal, antiviral, antiparasitic, hypoglycemic, antispasmodic, and anti-tumor effect on certain cell lines.

Conclusion. As a result of studying the literature and systematizing the current information on the chemical composition of the medicinal plant raw material of the black nut and the pharmacological properties of its main biologically active compounds, it has been established that the main properties are related to the presence of the phenol complex. However, a deeper study of the chemical composition is required. Both the total extracts of the black walnut from plant raw materials and individual compounds show predominantly antimicrobial, antifungal, antioxidant, antiviral, hypotensive, immunomodulatory, antitumor and antispasmodic activities in preclinical trials.
Evaluation of Pharmacokinetical Parameters of Phenol, a Component of Antiseptic Dorogov's stimulator 3 Fraction Paste
Authors: Nozdrin V. I. , Piavchenko G. A. , Ivanova M. E. , Guzev K. S. , Kuznetsov S. L.
Published: September 2019

Introduction. Antiseptic Dorogov's stimulator 3rd fraction (ASD-3) is a multicomponent substance, which is obtained by the thermal processing of cattle-origin tissues, which contains more than 120 substances, including biologically active substances. Among the components of ASD-3, necessary for quantitative analysis, pyrrole, phenol, cresol and its derivatives, and indole are distinguished as components. Despite the fact that antiseptic Dorogov's stimulator 3rd fraction was discovered more than half a century ago, there is no information about the pharmacokinetics of the drug components to date. Phenol is one of the preferred substances for research because that is a substance applied in the pharmaceutical technology for the manufacture of medicines.

Aim. Study of pharmacokinetic parameters of phenol as a component of a drug containing an antiseptic Dorogov's stimulator 3rd fraction in a dose of 0.5 g/kg, with a single use in a blood serum of 84 female rats weighing 100–120 g.

Materials and methods. In the blood serum of the 84 female Wistar rats weighing 100–120 g a study of a phenol pharmacokinetics as a component of ASD-3 drug in a dose of 0.5 g/kg was performed by a single skin application. The first group of animals was intraperitoneally injected with an aqueous emulsion containing 5% ASD-3, while the second one received zinc paste containing 5% ASD-3 on a skin surface. After the application of the emulsion or paste, the animals were euthanized after 0.25; 0.5; 1; 1.5; 2; 6 and 8 hours with further collection of blood from the abdominal aorta into centrifuge tubes. The study was carried out by high performance liquid chromatography.

Results and discussion. The elimination rate constant for intraperitoneal drug emulsion injection is 0,0968 h-1, and when the drug paste is applied, 0.0581 h-1. As a result, the half-life of phenol in the first case is 7.2 hours, and in the second case – 11.9 hours. The relative bioavailability of the phenol from the paste containing 5% of the ASD-3 is 14.38% to the 5% emulsion injected into the rats body intraperitoneally.

Conclusion. Comparison of the phenol concentration in the blood serum of experimental animals in two ways of application showed that the skin application of a drug paste containing 5% of ASD-3 provides a 10 times lower content of phenol in the blood serum compared to the intraperitoneal application of an emulsion with 5% ASD-3. 15 minutes after the skin application, the components of the drug start to be detected in the blood serum, reaching its maximum concentration in 1.5–2 hours, subsequently gradually decreasing.
Influence of the Method of Treatment of Samples of Biological Nature on the Results of Determination of Heavy Metals by Atomic Emission Spectroscopy
Authors: Blokhina E. N. , Kelus N. V. , Chuchalin V. S.
Published: September 2019

Introduction. The article is devoted to the relevance of choosing sample preparation method for heavy metals concentration determination in biological sample by using atomic emission spectrometry. Much attention is given to compare 2 methods of sample preparation: solid-phase extraction and microwave decomposition. As the result of analysis of heavy metals Fe, Zn, Rb, Cu, Ni, Al, Mn content using these sample preparation methods the following conclusions are drawn: maximum extraction of heavy metals is achieved by using microwave decomposition method.

Aim. The purpose of this work was to compare the methods and conditions for the sample preparation of biological samples for the determination of the content of heavy metals using atomic emission spectrometry.

Materials and methods. The object of the study to determine the content of heavy metals (Zn, Rb, Cu, Ni, Al, Mn) was the liver of golden hamsters of both sexes weighing 60–145 g of the type Golden Syrian SPF category, obtained from the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (Novosibirsk). Quantitative determination of heavy metals in biological samples was carried out on an Agilent 4100 atomic emission spectrometer with a microwave plasma (Agilent Technologies, USA).

Results and discussion. Comparison of the content of elements in the sample using the sample preparations under study showed that the maximum extraction of heavy metals from biological samples is achieved when using the method of microwave decomposition. The most complete extraction of heavy metals from biological samples is achieved by extraction within 30 minutes.

Conclusion. This method warrants the maximum metal extraction, is more accurate, rapid and less labor intensive compared to other methods considered, and is suitable for determining most heavy metals.
Nephron Prorenin Receptor Deficiency Alters Renal Medullary Endothelin-1 and Endothelin Receptor Expression
Authors: RAMKUMAR N. , STUART D. , ABRAHAM N. , KOHAN D. E.
Published: September 2019

The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption. It is unknown if the CD ET and renin/PRR systems interact, hence we examined the effects of deleting CD renin or nephron PRR on CD ET system components. PRR knockout (KO) mice were polyuric and had markedly increased urinary ET-1 and inner medullary CD (IMCD) ET-1 mRNA. PRR KO mice had greatly increased IMCD ETA receptor mRNA and protein, while ETB mRNA and protein were decreased. Water loaded wild-type mice with similar polyuria as PRR KO mice had modestly increased urinary ET-1 excretion and inner medullary ET-1 mRNA, while inner medullary ETA and ETB mRNA or protein expression were unaffected. In contrast to PRR KO, CD prorenin/renin KO did not alter ET system components. Taken together, these results suggest that the nephron PRR is involved in regulating CD ET system expression, but this effect may be independent of CD-derived renin.
The Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Improves Hypoxia-Induced Pulmonary Hypertension in Mice Partly via Normalization of Reduced ETB Receptor Expression
Authors: HONDA J. , KIMURA T. , SAKAI S. , MARUYAMA H. , TAJIRI K. , MURAKOSHI N. , HOMMA S. , MIYAUCHI T. , AONUMA K.
Published: September 2019

The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is an incretin hormone mimetic used in the treatment of diabetes. However, the effects of liraglutide on pulmonary hypertension (PH) and pulmonary endothelin (ET) system are unknown. Eight-week-old C57BL6/J mice were injected liraglutide or vehicle for 5 weeks. One week after injection, the mice were exposed to either room air (normoxia) or chronic hypoxia (10 % O2) for 4 weeks. The right ventricular systolic pressure (RVSP) was significantly higher in hypoxia + vehicle group than in normoxia + vehicle group. ET-1 mRNA expression in the lungs was comparable among all the groups. ETB mRNA and protein expression in the lungs was significantly lower in hypoxia + vehicle group than in normoxia + vehicle group. The above changes were normalized by liraglutide treatment. The expression of phospho-eNOS and phospho-AMPK proteins in the lungs was significantly higher in hypoxia + liraglutide group than in normoxia + vehicle group. We demonstrated for the first time that liraglutide effectively improved RVSP and RV hypertrophy in hypoxia-induced PH mice by activating eNOS through normalization of impaired ETB pathway and augmentation of AMPK pathway. Therefore, GLP-1R agonists can be promising therapeutic agents for PH.
Renoprotective Effects of ETA Receptor Antagonists Therapy in Experimental Non-Diabetic Chronic Kidney Disease: Is There Still Hope for the Future?
Authors: VANĚČKOVÁ I. , HOJNÁ S. , KADLECOVÁ M. , VERNEROVÁ Z. , KOPKAN L. , ČERVENKA L. , ZICHA J.
Published: September 2019

Chronic kidney disease (CKD) is a life-threatening disease arising as a frequent complication of diabetes, obesity and hypertension. Since it is typically undetected for long periods, it often progresses to end-stage renal disease. CKD is characterized by the development of progressive glomerulosclerosis, interstitial fibrosis and tubular atrophy along with a decreased glomerular filtration rate. This is associated with podocyte injury and a progressive rise in proteinuria. As endothelin-1 (ET-1) through the activation of endothelin receptor type A (ETA) promotes renal cell injury, inflammation, and fibrosis which finally lead to proteinuria, it is not surprising that ETA receptors antagonists have been proven to have beneficial renoprotective effects in both experimental and clinical studies in diabetic and non-diabetic CKD. Unfortunately, fluid retention encountered in large clinical trials in diabetic CKD led to the termination of these studies. Therefore, several advances, including the synthesis of new antagonists with enhanced pharmacological activity, the use of lower doses of ET antagonists, the addition of diuretics, plus simply searching for distinct pathological states to be treated, are promising targets for future experimental studies. In support of these approaches, our group demonstrated in adult subtotally nephrectomized Ren-2 transgenic rats that the addition of a diuretic on top of renin-angiotensin and ETA blockade led to a further decrease of proteinuria. This effect was independent of blood pressure which was normalized in all treated groups. Recent data in non-diabetic CKD, therefore, indicate a new potential for ETA antagonists, at least under certain pathological conditions.
DETERMINAN KEBIJAKAN DIVIDEN PADA PERUSAHAAN TELEKOMUNIKASI DI INDONESIA
Authors: Ismawati Linna
Published: September 2019

Abstract. The purpose of this research is to identify the determinants of corporate dividend policy At The Telecommuniactions in Indonesian. The Study uses a firm-level panel data set of four publicly traded the telecommunications on Indonesian Stock Exchange between 2010-2015. The Study develops four research hypotheses, which are used to represent the main theories of corporate dividends. The design of analysis used is multiple regression analysis, correlation coefficient analysis, and coefficient of determination analysis, while hypothesis testing using T test and F test. The Result in partial effect Return On Equity  gives significantly positive effect on Dividend Payout Ratio (DPR), while Current Ratio and Debt To Equity Ratio are not significant effect on Dividend Payout Ratio. In simultaneously Effect Return On Equity, Current Ratio, Debt To Equity Ratio have effect to Dividend Payout Ratio.Keywords. current ratio; debt to equity ratio; dividend payout ratio; return on equity. Abstrak. Penelitian ini bertujuan untuk mengidentifikasi determinan kebijakan dividen pada perusahaan telekomunikasi di Indonesia. Penelitian menggunakan data panel empat perusahaan telekomunikasi yang terdaftar di Bursa Efek Indonesia tahun 2010-2015. Dalam penelitian ini disusun empat hipotesis penelitian, yang digunakan untuk mewakili teori utama kebijakan dividen. Rancangan analisis yang digunakan adalah analisis regresi berganda, analisis koefisien korelasi, dan analisis koefisien determinasi, sedangkan pengujian hipotesis menggunakan uji T dan uji F. Hasil penelitian menunjukkan bahwa secara parsial tingkat pengembalian modal berpengaruh terhadap kebijakan dividen, tetapi rasio lancar dan rasio hutang tidak berpengaruh signifikan terhadap kebijakan dividen. Secara simultan tingkat pengembalian modal, rasio lancar, dan rasio hutang berpengaruh terhadap kebijakan dividen.Katakunci. rasio hutang; rasio lancar; rasio pembayaran dividen; tingkat pengembalian modal.
ANALISIS PERBANDINGAN KINERJA KEUANGAN PERUSAHAAN FARMASI MILIK BUMN DAN SWASTA
Authors: Mardiyani Mardiyani
Published: September 2019

Abstract. This research as a purpose to comparative analysis of financial performance in the pharmacy state owned corporation with private corporation listed in Indonesian Stock Exchange during 2010-2014 periods. The methodologies of Reseach is descriptive compatative, sampling used was 8 companies listed in ISE for 5 periods. Analysis technique used was Independen sample T-test. The Result of analysis show that comparative of financial performance in the pharmacy state owned corporation with private corporation base on ROE is be found significantly differentiation because the private corporation ROE is safe position on 15%, where as state owned corporation ROE is under safe position. If looked base on EPS is be found significantly differentiation between pharmacy state owned corporation with private corporation because private corporate EPS better than state owned corporate. For EVA value the pharmacy state owned corporation with private corporation not be found significantly differentiation because the second corporate have  EVA negative.Keywords. financial performance; ROE; EPS; EVA Abstrak. Penelitian ini bertujuan untuk menganalisis perbandingan kinerja keuangan perusahaan farmasi milik BUMN dan Swasta yang terdaftar di Bursa Efek Indonesia dari tahun 2010 – 2014. Metode penelitian yang digunakan deskriptif komparatif, dengan sampel 8 perusahaan farmasi yang terdaftar di BEI selama 5 tahun. Sementara teknik pengolahan data menggunakan Independen sample T-test. Hasil penelitian menunjukkan bahwa Perbandingan kinerja keuangan perusahaan farmasi milik BUMN dan Swasta berdasarkan ROE terdapat perbedaan yang signifikan karena ROE milik swasta ada di posisi aman dengan persentase diatas 15%, sementara persentase ROE perusahaan farmasi BUMN masih dibawah posisi aman. Apabila dilihat berdasarkan EPS terdapat perbedaan signifikan antara EPS perusahaan farmasi milik BUMN dan swasta karena laba per lembar saham milik perusahaan farmasi Swasta rata-ratanya jauh lebih tinggi dari perusahaan BUMN. Namun untuk nilai EVA perusahaan farmasi BUMN dan swasta tidak terdapat perbedaan yang signifikan karena kedua jenis perusahaan ini sama-sama memiliki nilai EVA negatif.Katakunci. kinerja keuangan; ROE; EPS; EVA
PENGARUH KUALITAS PELAYANAN DAN PERSEPSI HARGA TERHADAP KEPUASAN MAHASISWA SERTA IMPLIKASINYA PADA CITRA PERGURUAN TINGGI
Authors: Sulastri Tuti
Published: September 2019

Abstract. This study aims to determine the effect of service quality and price perception on student satisfaction and its implications on the image of colleges. Data analysis was conducted on a sample of 80 students. Data were obtained through a questionnaire and analyzed using path analysis. The result of processing the data reveals that the service quality influences the students satisfaction there is 30,6% direct influence and 18,8% indirect influence through the price perception, thus the total influence amounts to 49,9%. These results indicate that the effect is quite strong category;  the result of processing the data also reveals that price perception also influence students satisfaction to extent as follows 16,5% direct influence, and 18,8% indirect influence through service quality,  the total  of influence is 35,3%. These results indicate that the effect is quite strong category; the influence of price  perceptions and service quality simultaneously on student satisfaction was 84,7%. The results show a very strong influence category; and the influence of satisfaction on colleges image was  reveals that 87,4%. The results show a very strong influence category.Keywords. service quality; price perception; student satisfaction; and college image. Abstrak. Penelitian  ini bertujuan untuk mengetahui pengaruh kualitas pelayanan dan persepsi harga terhadap kepuasan mahasiswa serta implikasinya pada Citra Perguruan Tinggi. Analisis data dilakukan terhadap sampel sebanyak 80 mahasiswa. Data diperoleh melalui kuesioner dan diolah menggunakan analisis jalur (path analysis). Sesuai dengan hasil pengolahan data yang dilakukan, diperoleh pengaruh kualitas pelayanan terhadap kepuasan mahasiswa, yaitu pengaruh langsung sebesar 30,6%, pengaruh tidak langsung melalui persepsi harga sebesar 18,8%, dengan demikian pengaruh total sebesar 49,4%,  hasil tersebut menunjukkan pengaruh yang berkategori cukup kuat.  Sedangkan pengaruh persepsi harga terhadap kepuasan mahasiswa yaitu pengaruh langsung 16,5%, pengaruh tidak langsung melalui kualitas pelayanan sebesar 18,8% sehingga total sebesar 35,3%. Hasil tersebut menunjukkan pengaruh yang berkategori cukup kuat; pengaruh kualitas pelayanan dan persepsi harga secara simultan terhadap kepuasan mahasiswa sebesar 84,7%.  Hasil tersebut menunjukkan pengaruh yang berkategori sangat kuat; sedangkan pengaruh kepuasan mahasiswa terhadap Citra Perguruan Tinggi sebesar 87,4%. Hasil tersebut menunjukkan pengaruh yang berkategori sangat kuat.Katakunci. kualitas pelayanan; persepsi harga; kepuasan mahasiswa; citra perguruan tinggi.
Hubungan Risiko, Kinerja, Kebijakan Dividen dan Nilai Perusahaan (Studi Empirik pada Industri Perbankan di Indonesia)
Authors: Sudiyatno Bambang , Puspitasari Elen , Irsad Moch
Published: September 2019

Abstract. This study is a quantitative research to examine the influence and relationship of risk, performance, dividend policy, and firm value. Data analysis was done by Multiple Regression and Logistic Regression method. The result shows that the Non Performance Loan (NPL) and Loan to Deposit Ratio (LDR) have a negative and significant influence to Bank Performance (ROA), while Net Interest Margin (NIM) has a positive and significant impact on Bank Performance (ROA). Other findings indicate that Bank Performance (ROA) has a positive effect and  significant to Price to Book Value (PBV), and banks that generate high ROA tend to divide Dividends. Keywords: NPL; LDR; NIM; ROA; PBV; Dividend Policy. Abstrak. Penelitian ini merupakan penelitian kuantitatif yang menguji pengaruh dan hubungan antara risiko, kinerja, kebijakan dividen, dan nilai perusahaan. Analisis data dilakukan dengan metode analisis Multiple Regression dan Logistic Regression. Hasil penelitian menunjukkan bahwa Non Performance Loan (NPL) dan Loan to Deposit Ratio (LDR) berpengaruh negatif dan signifikan terhadap Kinerja Bank (ROA), sedangkan Net Interest Margin (NIM) berpengaruh positif dan signifikan terhadap Kinerja Bank (ROA). Temuan lainnya menunjukkan bahwa Kinerja Bank (ROA) berpengaruh positif dan signifikan terhadap Price to Book Value (PBV), dan bank-bank yang menghasilkan ROA tinggi cenderung membagi Dividen. Kata Kunci: NPL; LDR;, NIM; ROA; PBV; Dividend Policy.
Knowledge Sharing Sebagai Mediasi Pengaruh Learning Organization Terhadap Kinerja Karyawan
Authors: Safitri Cintya Lely , Setyanti Sri Wahyu Lelly Hana , Sudarsih Sudarsih
Published: September 2019

Abstract. The purpose of this research is to analyze the influence of learning organization on employee performance with knowledge sharing as mediating. This research can be classified as explanatory research, the research explains about the correlation between several variables through hypothesis testing. The sampling technique used is census technique where the whole population of PT Telekomunikasi Tbk Lumajang as the research sample which is 40 employees. The research method is path analysis. The result showed that Learning organization has a significant impact on Knowledge sharing, Learning organization has a significant impact on employee performance, Knowledge sharing has a significant impact on employee performance, and learning organization has a significant impact on employee performance with Knowledge sharing as mediating. Further research is expecting to analyze another variable a mediating such as organizational culture, service quality, and organizational commitment.   Keywords: employee performance, Knowledge sharing; Learning organization Abstrak. Penelitian ini bertujuan untuk menguji pengaruh dari Learning organization terhadap Kinerja melalui knowledge sharing. Penelitian ini dapat diklasifikasikan sebagai exsplanatory research, yaitu penelitian yang menjelaskan hubungan kausal dan menguji keterkaitan antara beberapa variabel melalui pengujian hipotesis atau penelitian penjelasan. Populasi dari penelitian ini adalah seluruh karyawan PT Telekomunikasi Tbk Lumajang yaitu berjumlah 40 orang. Teknik pengambilan sampel yang digunakan adalah Sensus,yaitu semua populasi dijadikan sebagai sampel karena pada penelitian ini melibatkan seluruh karyawan PT Telekomunikasi Tbk Lumajang. Metode analisis yang digunakan pada penelitian ini adalah Path analysis atau analisis jalur dan alat hitung yang digunakan yaitu SPSS 16. Hasil penelitian menunjukkan bahwa Learning Orgnization (X) berpengaruh signifikan terhadap Knowledge sharing(Z), Learning Orgnization (X) berpengaruh signifikan terhadap kinerja karyawan (Y), Knowledge sharing(Z) berpengaruh signifikan terhadap kinerja karyawan (Y), Learning Orgnization (X) berpengaruh signifikan terhadap kinerja karyawan (Y) melalui Knowledge sharing(Z). Penelitian selanjutnya diharapkan menambahkan variabel mediasi misalnya budaya organisasi, kinerja kualiltas pelayanan dan komitmen organisasi. Katakunci: Knowledge sharing; Learning organization, Kinerja karyawan
Determinasi Free Cash Flow Terhadap Return on Equity Dan Kebijakan Pembayaran Dividen
Authors: Mardiyani Mardiyani
Published: September 2019

Abstract. This study aims to find out the effect of Free Cash Flow on Return On Equity and dividend payment policy on consumption sector manufacturing companies for the period 2012-2016. The research method uses causal associative with a sample of 14 companies for 5 years. As for data processing techniques using the LISREL 8.8 Path Analysis format. The results showed that there was a positive influence between Free Cash Flow, ROE and dividend payment policy. This means that if the value of the Free Cash Flow and ROE of the company increases, the shareholder dividend will be higher. The effort that must be made by the company to increase shareholder dividends is to limit debt so that the net income obtained is allocated more for reinvestment (Free Cash Flow) so that the ROE and welfare of shareholders increases. Keywords: Dividend Payout Policy, Return On Equity (ROE), Free Cash Flow (FCF) Abstrak. Penelitian ini bertujuan untuk mencari pengaruh Free Cash Flow terhadap Return On Equity dan kebijakan pembayaran dividen pada perusahaan manufaktur sektor Konsumsi periode 2012-2016. Metode penelitian menggunakan asosiatif kausal dengan sampel sebanyak 14 perusahaan selama 5 tahun. Adapun teknik pengolahan data menggunakan Path Analysis format LISREL 8.8. Dari hasil penelitian didapatkan bahwa terdapat pengaruh positif antara Free Cash Flow, ROE dan kebijakan pembayaran dividen, yang artinya jika nilai Free Cash Flow dan ROE perusahaan meningkat maka dividen pemegang saham akan semakin tinggi. Upaya yang harus dilakukan perusahaan untuk meningkatkan dividen pemegang saham adalah dengan membatasi hutang agar net income yang diperoleh lebih banyak dialokasikan untuk reinvestasi (Free Cash Flow) sehingga ROE dan kesejahteraan pemegang saham meningkat. Kata Kunci : Kebijakan pembayaran dividen, Return On Equity (ROE), Free Cash Flow (FCF).
Pengaruh Disiplin Kerja dan Kepuasan Kerja Terhadap Kinerja Karyawan
Authors: Prasetyo Ery Teguh , Marlina Puspa
Published: September 2019

Abstract: The purpose of this study was to determine the effect of work discipline and job satisfaction on employee performance at PT. Nihon Plast Indonesia. The research method used is quantitative. The population in this study were employees at PT. Nihon Plast Indonesia with 100 people. The sample measurement technique uses Slovin formula with a margin of error of 5% so that the number of samples used is 80 respondents. The sampling technique uses simple random sampling. The data withdrawal technique used is a questionnaire. Data analysis using multiple linear regression with the help of SPSS 23. The results of the study show that there is a positive and significant influence between the variables of work discipline and job satisfaction on employee performance. Keywords: work discipline, job satisfaction, employee performance.  Abstrak : Tujuan penelitian ini untuk mengetahui pengaruh disiplin kerja dan kepuasan kerja terhadap kinerja karyawan di PT. Nihon Plast Indonesia. Metode penelitian yang digunakan adalah kuantitatif. Populasi dalam penelitian ini adalah karyawan pada PT. Nihon Plast Indonesia dengan jumlah 100 orang. Teknik pengukuran sampel menggunakan rumus  slovin dengan margin of eror 5% sehingga jumlah sampel yang digunakan sebanyak 80 Responden. Teknik penarikan sampel menggunakan simple random sampling. Teknik penarikan data yang digunakan adalah kuesioner. Analisis data dengan menggunakan regresi linier berganda engan bantuan aplikasi SPSS 23. Hasil penelitian menunjukan bahwa terdapat pengaruh yang positif dan signifikan antara variabel disiplin kerja dan kepuasan kerja terhadap kinerja karyawan. Katakunci: disiplin kerja, kepuasan kerja, kinerja karyawan
MAIN SOIL CULTIVATION IN CROP ROTATION WITH LUPIN FOR BRYANSK REGION CONDITION
Authors: Исаева Елена , Isaeva Elena
Published: September 2019

Tests results have been got on gray forest soil in the South-West of the Non-Chernozem zone of Bryansk region in the stationary experiment in the All-Russian Research Institute of Lupine in 2015–2018. The aim of the test was to evaluate a hectare of crop rotation area of four field lupin crop rotation (winter wheat – bare oats – winter triticale – lupin) for production of feed and energy effectiveness at different technics of the main soil cultivation. The variant of dump ploughing with deep loosening once in four years for lupin has the highest productivity of feed and energy effectiveness per a hectare of crop rotation area. Each crop of the crop rotation has high indices of yield and quality of grain products at this way of soil cultivation. The tested four-field lupin crop rotation is more energetically stable at the variant of the main soil cultivation — traditional ploughing with deep loosening. Efficiency coefficient of the crop rotation was 3.15 in the first cycle and the coefficient of energy effectiveness was 2.15. The other variants of the main soil cultivation could be used too in multiform farms of a region to provide quite high profitability.
STRENGTHENING OF A BIOLOGICAL FACTOR IN MIXED COENOSES BY LUPIN USE
Authors: Руцкая Валентина , Ruckaya Valentina , Сорокин Александр , Sorokin Alexander , Исаева Елена , Isaeva Elena
Published: September 2019

Heterogeneous crops are more close to natural bio-coenosis compared with the single ones. In mixed coenosis competition relations present between plants at certain conditions. The relations are based on direct competition for the main survive factors with physical-mechanical and biochemical interaction. But co-growth of plants causes not only negative interaction but often it has a positive action on coenosis components. To avoid tensions in agrocoenosis the principle of crop complementarity should be taken into account at selection of components for mixed crops which complement each other. Lupin demonstrates its biological potential in coenosis significantly better compared to the other grain legumes and is a factor for mobilization and use of sun energy and other natural resources. In experiments interaction type have been tested between narrow-leafed lupin SN-78-07 and white lupin var. Alyi Parus (2018), oat var. Pamyati Balavina, Sudan grass var. Kinelskaya 100 as components of mixed crops for their average yield. Their competitiveness ability and aggression level are studied. Aggression coefficient and competitiveness ratio have been used to evaluate interactions. The article presents the strengthening of a biological factor in mixed coenosis when grain crops use lupin as a component of nitrogen accumulation and melioration of environment.
MEADOW CLOVER SELECTION FOR THE CONDITIONS OF SOUTH FOREST-STEPPE AND FLOODPLAIN THE CENTRAL BLACK EARTH REGION
Authors: Сапрыкин Сергей , Saprykin Sergey , Иванов Иосиф , Ivanov Iosif , Лабинская Раиса , Labinskaya Raisa , Сапрыкина Наталья , Saprykina Natal'ya , Ульянцева Валентина , Ulyantseva Valentina , Чекмарева Анна , Chekmareva Anna
Published: September 2019

For forage production of the Central Black-Earth Region clover is important. This crop can be effectively used in field crop rotations, to improve natural forage lands and to create cultural hayfields and pastures. Clover meadow has high feed advantages, allowing to fill the protein deficiency, is able to produce good yields, better than alfalfa grows on slightly acidic soils. For the most complete realization of the potential of clover it is necessary to create high-yielding two-cut varieties of meadow clover, which have good winter hardiness and drought resistance, have time to ripen for seeds in the second mowing and adapted to the soil and climatic conditions of the region. The article presents the results of more than 10 years of selection work to create a new variety of meadow clover Voronezhskiy. The variety was created by the method of polycross progeny of the best varieties of populations with a heterogeneous genetic nature, with high and stable heterosis, which were isolated from promising collection samples, followed by biotypic selection. The characteristics of the variety are given and the test results are given at in State varietal plots in a number of regions of the Central Black Earth Region. The new variety is better adapted to the changing climatic conditions of the region. In 2015, the Voronezhskiy clover variety was included in the State Register for the Central Black Earth (5) Region. Testing continues in the Volga-Vyatka and Middle Volga regions.
Validation of a Test Platform to Qualify Miniaturized Electric Propulsion Systems
Authors: Stesina Fabrizio
Published: September 2019

Miniaturized electric propulsion systems are one of the main technologies that could increase interest in CubeSats for future space missions. However, the integration of miniaturized propulsion systems in modern CubeSat platforms presents some issues due to the mutual interactions in terms of power consumption, chemical contamination and generated thermal and electro-magnetic environments. The present paper deals with the validation of a flexible test platform to assess the interaction of propulsion systems with CubeSat-technologies from mechanical, electrical, magnetic, and chemical perspectives. The test platform is a 6U CubeSat hosting an electric propulsion system and able to manage a variety of electric propulsion systems. The platform can regulate and distribute electric power (up to 60 W), exchange data according to several protocols (e.g., CAN bus, UART, I2C, SPI), and provide different mechanical layouts in 4U box completely dedicated to the propulsion system. Moreover, the data gathered by the onboard sensors are combined with the data from external devices and tools providing unprecedented information about the mutual behavior of a CubeSat platform and an electric propulsion system.