bluuebunny/crossref_metadata_2025 huggingface dataset:
The Tango Between Art.17(3) Brussels Ibis and Art.6(4)(b) Rome I under the Beat of Package Travel Directive
Authors: Chen Zhen
Published: December 2021

Package travel tourists are explicitly protected as consumers under Article 6(4)(b) Rome I, but not under Article 17(3) Brussels Ibis since it does not even mention the term ‘package travel’. Such discrepancy is widened with the replacement of Directive 90/314 by Directive 2015/2302 with enlarged notion of package travel. As regards protecting package travel tourists as consumers with favorable jurisdiction and applicable law rules, this article argues that Article 17(3) Brussels Ibis is two steps behind Article 6(4)(b) Rome I. In order to close the gap, a uniform concept of package travel should be given. To this end, it is suggested that Article 17(3) Brussels Ibis should adopt the notion of package travel employed in Article 6(4)(b) Rome I. Despite this, these two provisions only cover packages containing transport, as an exception of transport contracts. Packages not including transport do not fall under the exception of transport contracts. Since all package travel contracts should be protected as consumer contracts, regardless of containing transport or not, it is more logical to delete the exception of transport contracts and create a separate provision to protect package travel contracts as consumer contracts.
Factors Influencing Academic Self-Efficacy Among Nursing Students During COVID-19: A Path Analysis
Authors: Han ShinHi , Eum Koun , Kang Hee Sun , Karsten Kathleen
Published: December 2021

Introduction:

The shift to online learning owing to the coronavirus disease 2019 pandemic is posing an additional challenge to academic success, particularly for students who speak English as a Second Language (ESL). This study aimed to examine the factors that contribute to academic self-efficacy among ESL nursing students.

Method:

This was a cross-sectional study using path analysis with 113 undergraduate ESL nursing students in New York City. Data were collected online using self-report measures of the study variables: academic self-efficacy, perfectionistic concerns, acculturative stress, and e-learning stress. A hypothetical path model was tested using AMOS 26.0.

Results:

Perfectionistic concerns and acculturative stress directly affected academic self-efficacy. Furthermore, perfectionistic concerns and e-learning stress indirectly affected academic self-efficacy via the acculturative stress path.

Discussion:

Results indicate the importance of developing a multifaceted intervention that considers diverse cultural and psychological factors to help ESL nursing students enhance their academic self-efficacy in e-learning environments.
Thematic Analysis of Coping Strategies Used by Parents of Children with Cleft Lip and Palate in El Salvador
Authors: Aleman Ramon Manuel , Martinez Maria Guadalupe
Published: December 2021

Objective

The aim of this study was to describe coping strategies used by parents of children with cleft palate with or without a cleft (CP ± L) during the early development of their children in El Salvador.

Design

Qualitative interviews were completed with 16 parents of children born with CP ± L who were 6 months to 6 years old. Parents were questioned about their emotions and coping during eight time periods: prenatal, birth, social interaction before the first surgery, the beginning of surgeries, social interaction after the first surgery, early childhood education (ECE), speech–language therapy, and formal education. Thematic analysis (TA) was used to identify coping strategies as conceptualized by Lazarus and Folkman (1984) .

Results

Four major themes emerged: (a) experienced emotions related to diagnosis, (b) interpretations related to the birth of a child with a cleft, (c) seeking and experiencing cleft treatment, and (d) social interaction of the children. During prenatal and birth stages, parents used emotion-focused strategies. A few hours to a week after birth, they used problem-focused strategies, which led them in search of treatment. Some parents used avoidance strategies during periods of social interaction before surgery, ECE, and formal education. Socioeconomic challenges impacted access to speech–language therapy. Sociocultural factors, such as discrimination, religion, and folk beliefs, appeared to influence some of the coping strategies used by parents.

Conclusions

Problem-focused strategies appear to be helpful in seeking surgical treatments. The emotion-focused strategy of avoidance seemed to have adverse effects in minimizing opportunities for social interaction prior to surgery and early education.
Effect of Recombinant Human Soluble Thrombomodulin on Coagulation-Related Variables in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Retrospective Observational Study
Authors: Mitaka Chieko , Kawagoe Izumi , Satoh Daizoh , Hayashida Masakazu
Published: December 2021

To evaluate associations among coagulation-related variables, resolution of disseminated intravascular coagulation (DIC) and mortality, we retrospectively investigated 123 patients with sepsis-induced DIC treated with recombinant human soluble thrombomodulin (rTM). Changes in coagulation-related variables before and after treatment with rTM were examined. Further, associations between coagulation-related variables and DIC resolution were evaluated. The platelet count, prothrombin international normalized ratio (PT-INR), and fibrin/fibrinogen degradation products (FDP) significantly ( p < .001) improved after rTM administration in survivors (n = 98), but not in nonsurvivors (n = 25). However, the DIC score significantly ( p < .001) reduced in survivors and in nonsurvivors. Among coagulation-related variables examined before rTM, only PT-INR was significantly ( p = .0395) lower in survivors than in nonsurvivors, and PT-INR before rTM was significantly ( p = .0029) lower in patients attaining than not attaining DIC resolution (n = 87 and 36, respectively). The 28-day mortality was significantly lower in patients attaining than not attaining DIC resolution (11.5% vs 41.7%, p = .0001). In conclusion, the initiation of rTM administration before marked PT-INR elevation may be important to induce DIC resolution and thus to decrease mortality in patients with sepsis-induced DIC. Conversely, the treatment with rTM in patients with marked PT-INR elevation may be not so effective in achieving such goals.
A Risk of Venous Thromboembolism Algorithm as a Predictor of Venous Thromboembolism in Patients with Colorectal Cancer
Authors: Chen Ying , Wang Yanchun , Xie Suhong , Zheng Hui , Tong Ying , Gao Xiang , Lu Renquan , Guo Lin
Published: December 2021

Cancer patients experience an increased risk of venous thromboembolism (VTE). In this study, we investigated a risk of venous thromboembolism algorithm (RVTA) in patients with colorectal cancer and evaluated its ability to predict the prognosis of colorectal cancer. We retrospectively analyzed clinical data from 345 patients with colorectal cancer from January 2015 to December 2018 at the Shanghai Cancer Center to develop the RVTA. Additionally, the 345 patients were followed until December 2020 for prognostic analysis. The RVTA included the following variables: (a) platelet count, (b) blood transfusion history, (c) metastasis, (d) multiple chemotherapy regimens, and (e) the D-dimer level. Good predictive efficiency was observed for the RVTA (AUC was 0.825; 95% CI was 0.721 to 0.930). The median progression-free survival (PFS) of patients who had a score less than 4 (0-3), defined as the low-risk group, was significantly longer than that of the high-risk group, which included patients who had a score greater than 4 (4-8) (26 vs ten months, P < .001). The RVTA was a valuable predictor for VTE risk and had prognostic value in colorectal cancer.
Cultural Adaptation and Validation into Spanish of the Scale to Measure Attitudes Towards the Sex Trafficking of Women and Girls in Students of the University of Salamanca
Authors: Herrero-Villoria Cristina , Picornell-Lucas Antonia , Patino-Alonso Carmen
Published: December 2021

The aim of this study was to validate and analyze the psychometric properties of a Spanish version of the Sexual Trafficking Attitudes Scale towards women and girls (STAS). A sample of 204 students from the University of Salamanca (Spain) was used. The exploratory factor analysis and confirmatory factor analysis confirmed a multifactorial structure of six factors (70.1% of variance). The Cronbach’s α internal consistency index obtained for the sample was 0.87 and composite reliability was 0.94. Convergent validity was determined between the full scale and the six dimensions, and divergent between subscales. The Spanish version of the instrument consisted of 25 items, proving to be a reliable and parsimonious measure.
The Intercultural Role of Attitudes Towards Violence Against Women Among Moroccan Immigrants
Authors: Arnoso Ainara , Arnoso Maitane , Elgorriaga Edurne
Published: December 2021

The objective was to study the intercultural role of attitudes towards violence against women in the Moroccan immigrant population. A first study analyzes the relationship between sexism and intimate partner violence and the differences based on origin and sex. About 122 native Spanish people and Moroccan immigrants participated. Men and Moroccan immigrants had more sexist attitudes than women and native people, with no differences in intimate partner violence based on sex or origin. A second study using two focus groups with Moroccan immigrants showed the relevance of the traditional values of gender and culture of honor, religiosity, and the socio-economic context.
Money, Power, and Relationships: Economic Vulnerability in Girls’ Lives and Risk for Partner Violence Among Girls in Ibadan, Nigeria
Authors: Salawu Mobolaji M. , Okedare Omowumi O. , Reed Elizabeth , Kiene Susan M. , Fawole Olufunmilayo I.
Published: December 2021

This study explored the experience of economic vulnerability and its effect on girls’ future aspirations, relationships, and financial reliance on male partners, as well as risk for intimate partner violence (IPV) and related health consequences. Thirteen Focus Group Discussions (FGDs) were conducted among 122 female adolescents aged 15–19 years. Participants reported that lack of economic resources limits girls’ ability to be economically independent by reducing opportunities to receive education or enter into a trade. Economic vulnerability decreases girls’ ability to become economically independent, increasing financial reliance on male partners, and in turn, increasing risk for IPV, sexually transmitted infections, and unintended pregnancy.
Trafficking, Client and Police Violence, Sexual Risk and Mental Health Among Women in the Sex Industry at the Thai-Myanmar Border
Authors: Decker Michele R. , Meyer Sarah R. , Branchini Risko Casey , Abshir Nada , Mar Aye Aye , Robinson W. Courtland
Published: December 2021

This study describes sex trafficking and associations with violence and health among female migrants in the sex industry in Mae Sot, Thailand. The mixed-methods study included a qualitative interview phase ( n = 10), followed by a cross-sectional survey phase ( n = 128). Entry via trafficking (force, fraud, or coercion [FFC], or as minors) was prevalent (76.6%), primarily FFC (73.4%). FFC was associated with inconsistent condom use, inability to refuse clients, poor health, and anxiety. Past-year violence was normative including client sexual violence (66.4%), client coercion for condom nonuse (> 95%), and police extortion (56%). Working conditions enabled violence irrespective of mode of entry. Profound unmet needs exist for safety and access to justice irrespective of trafficking history.
Microvascular differences in amblyopic subgroups: An observational case–control study
Authors: Karabulut Müjdat , Karabulut Sinem , Sül Sabahattin , Karalezli Aylin
Published: December 2021

Purpose

To determine retinal microvascular differences among amblyopic subgroups and compare them with control eyes.

Study Design

This study was designed as an observational case–control study.

Methods

Twenty-three strabismic, 23 anisometropic, 22 meridional, 22 ametropic amblyopic eyes, and 24 healthy control eyes were included. The mean vessel densities in the deep and superficial capillary plexus, the foveal avascular zone area, the choriocapillaris flow area, and the foveal thickness were compared.

Results

Vessel density was markedly lower in all sectors of the amblyopic subgroups in the deep capillary plexus than in control eyes. Density was significantly lower in the superficial capillary plexus only in ametropic and meridional amblyopic eyes. Among these groups, the meridional amblyopic eyes had the largest choriocapillaris flow area ( p = 0.013) and the lowest vessel density in all sectors ( p < 0.001). The foveal avascular zone area was similar in all groups ( p = 0.561). The fovea was significantly thicker only in the anisometropic and meridional subgroups than control eyes ( p = 0.011, p = 0.001, respectively). The foveal avascular zone area was inversely related to the foveal thickness in all groups.

Conclusion

Retinal structural and microvascular differences were found among amblyopic subgroups. Optical coherence tomography angiography can noninvasively detect these variations, which may be related to the etiologic factors.
Differential model of friction based on bristle model and phase-transition theory
Authors: Wang Fan , Wang Lin-Xiang
Published: December 2021

For high-precision position and angle control in robots, it is essential to compensate for the hysteretic behaviour caused by friction when the motion direction is reversed. An accurate friction model which is suitable for control system analysis and implementation is highly desirable. A differential model is proposed in the current paper for the modelling of hysteresis effects caused by friction phenomena. The model is constructed by employing a phenomenological phase-transition theory to mimic the friction mechanism. The bristle friction mechanism is adapted. The switching between static and dynamic friction is regarded as a reversible phase-transition phenomenon, which could be characterized by the local minima of a non-convex potential energy function. The Stribeck effect and the hysteretic relation between friction and velocity are modelled by a nonlinear ordinary differential equation. The comparison of the numerical simulation results and existing experimental friction data are presented. It is illustrated that the friction hysteresis loops are well captured, the capability of the proposed model is verified.
The effectiveness of telehealth versus face-to face interventions for anxiety disorders: A systematic review and meta-analysis
Authors: Krzyzaniak Natalia , Greenwood Hannah , Scott Anna M , Peiris Ruwani , Cardona Magnolia , Clark Justin , Glasziou Paul
Published: December 2021

Introduction

Worldwide, it is estimated that 264 million people meet the diagnostic criteria for anxiety conditions. Effective treatment regimens consist of cognitive and behavioural therapies. During the COVID-19 pandemic, treatment delivery relied heavily on telemedicine technologies which enabled remote consultation with patients via phone or video platforms. We aim to identify, appraise and synthesise randomised controlled trials comparing telehealth to face-to-face delivery of care to individuals of any age or gender, diagnosed with anxiety disorders, and disorders with anxiety features.

Methods

To conduct this systematic review and meta-analysis, we searched three electronic databases, clinical trial registries and citing-cited references of included studies.

Results

A total of five small randomised controlled trials were includable; telehealth was conducted by video in three studies, and by telephone in two. The risk of bias for the 5 studies was low to moderate for most domains. Outcomes related to anxiety, depression symptom severity, obsessive-compulsive disorder, function, working alliance, and satisfaction were comparable between the two modes of delivery at each follow-up time point (immediately post-intervention, 3 months, 6 months and 12 months), with no significant differences reported ( p > 0.05). None of the trials reported on the costs of telehealth compared to face-to-face care.

Discussion

For effectively treating anxiety and related conditions, interventions delivered by telehealth appear to be as effective as the same therapy delivered in-person. However, further high-quality trials are warranted to determine the effectiveness, acceptability, feasibility, and cost-effectiveness of telehealth interventions for the management of a wider range of anxiety disorders and treatments.
A qualitative exploration of families’ experiences and resilience factors during the COVID-19 pandemic
Authors: Carney Jessica R , Behrens Brigid , Miller-Graff Laura E
Published: December 2021

The COVID-19 pandemic has prompted widespread changes and challenges worldwide. In the context of the early months of the pandemic, the current study utilized thematic analysis to assess parents’ ( N = 13) perspectives of need for resources to foster their family’s wellbeing. Five themes emerged: Information Deficits, Need for More Instrumental Supports, Frustration and Worry, Resources Promoting Resilience, and Positive Perspective Shift. Results indicate the importance of information and expanded access to community resources to scaffold resilience in the face of ongoing mass stressors.
“I put a stone on my heart and kept going”: An explanatory model of how distress is generated and regulated among Indian women from slums reporting gender-based violence
Authors: Patel Anushka R. , Kovacevic Merdijana , Hinton Devon , Newman Elana
Published: December 2021

Clinical variation in the expression of panic disorder, depression and anxiety, and posttraumatic stress disorder (PTSD) has have been documented across cultures. However, local (emic) cultural models that explain how people make sense of their illness experiences remain relatively understudied in India among trauma-exposed populations. Further, the integration of emic findings into clinical care is limited, underscoring the need for emic perspectives following trauma to improve the development or adaptation of trauma-focused treatments in India. This study describes an emic explanatory model of distress, which includes idioms of distress, perceived causes of distress, and coping/help-seeking behaviors among Indian women from slums reporting gender-based violence. This explanatory model can be used as a culturally grounded way to develop clinical case conceptualizations to adapt and deliver psychological treatments for this under-served population.
Book review: Sandya Hewamanne, Restitching Identities in Rural Sri Lanka: Gender, Neoliberalism, and the Politics of Contentment
Authors: Ruwanpura Kanchana N.
Published: December 2021

Sandya Hewamanne, Restitching Identities in Rural Sri Lanka: Gender, Neoliberalism, and the Politics of Contentment (Philadelphia, PA: University of Pennsylvania Press, 2020), 224 pp. $55, £44, ISBN 978-0-812-25240-8 (Hardback)
Book review: K. B. Newbold and K. Wilson (Eds.), A Research Agenda for Migration and Health
Authors: Ravindranath Divya
Published: December 2021

K. B. Newbold and K. Wilson (Eds.), A Research Agenda for Migration and Health (Edward Elgar Publishing, 2019), 176 pp. $80, ISBN: 9781786438355
Language teachers’ accounts of challenges in two European settings of integration training
Authors: Häkkinen Miira , Mikkilä-Erdmann Mirjamaija
Published: December 2021

This study investigates the work of second language teachers in two institutional settings responsible for integration training. By exploring teachers’ accounts in Finland and Germany, we seek to deepen the understanding of the daily practice of second language education. Bridging conceptual and practical approaches, the aim is to contribute to the current discourse on the development of adult second language education in Europe. A phenomenographic analysis of semi-structured interviews reveals challenges that influence instruction from inside and outside institutional practice. Accounts in the Finnish setting depict issues in how language education, teachers’ work, and adult education are perceived. Administration and language teachers disagree on what needs to be improved in a changing societal environment. Professional pride and appreciation are strongly demanded in a profession that is still being established, and challenges specific to adult education translate into priorities in delivering instruction. In the German setting, expressions culminate in prerequisites, and challenges lie in the way external factors influence course design and instruction. They also touch upon learning: methods, materials, and abilities. Feelings of inadequacy describe teachers’ psychological working environment. A comparison concludes a need to defend contact teaching in Finland and to improve tracking of slower learners’ progress in Germany.
Prerenal Transplant Education and Evaluation Positively Impacts Outcomes
Authors: Jesse Michelle T. , Clifton Erin , Kim Dean Y. , Nicholson Dayna , Patil Rujuta , Bhavsar Shweta , Desai Soham , Gartrelle Kendyll , Eshelman Anne , Fleagle Elizabeth , Ahmedani Brian , Carlozzi Noelle E. , Tang Amy , Patel Anita
Published: December 2021

Introduction: An outstanding question in kidney transplantation is how to prepare candidates and their social supports for optimal posttransplant outcomes. Project Aims: This program evaluation assessed whether a pretransplant quality improvement clinic improved clinical outcomes in the year posttransplant compared to recipients receiving standard of care. Design: The Countdown to Transplant Clinic was implemented with kidney transplant candidates expected to receive a transplant within the next few months. The clinic included an enhanced education session on posttransplant lifestyle management, confirmation of support (≥2 adults), and evaluations by transplant social work, psychology, and nephrology. Results: Seventy-five patients participated in the clinic and underwent a transplant. A retrospective chart review of posttransplant laboratory values, rehospitalizations (within 3-months posttransplant), biopsy-confirmed graft failure, and mortality (within 1-year posttransplant) were collected from both groups. Univariate and multivariate propensity score-weighted linear or logistic regression models were used to evaluate the association between clinic participation and outcomes. In models adjusting for relevant covariates, participation in The Countdown to Transplant Clinic (vs standard care) was associated with a lower coefficient of variation of serum tacrolimus (all values collected 3-12 months posttransplant), 30-day posttransplant white blood cell counts (but not 90-day), 90-day posttransplant potassium, and 30 and 31 to 90 days rehospitalizations. Clinic participation did not predict serum glucose levels at 30- or 90-days posttransplant. Due to low rates of rejection and mortality, meaningful comparisons were not possible. Conclusion: Participation in a pretransplant, multicomponent clinic may improve certain outcomes of interest posttransplantation. Pilot testing for feasibility for randomized controlled trials is a necessary next step.
Carbon “quantum” dots for bioapplications
Authors: Yuan Dekai , Wang Ping , Yang Liju , Quimby Jesse L , Sun Ya-Ping
Published: December 2021

Carbon “quantum” dots or carbon dots (CDots) exploit and enhance the intrinsic photoexcited state properties and processes of small carbon nanoparticles via effective nanoparticle surface passivation by chemical functionalization with organic species. The optical properties and photoinduced redox characteristics of CDots are competitive to those of established conventional semiconductor quantum dots and also fullerenes and other carbon nanomaterials. Highlighted here are major advances in the exploration of CDots for their serving as high-performance yet nontoxic fluorescence probes for one- and multi-photon bioimaging in vitro and in vivo, and for their uniquely potent antimicrobial function to inactivate effectively and efficiently some of the toughest bacterial pathogens and viruses under visible/natural or ambient light conditions. Opportunities and challenges in the further development of the CDots platform and related technologies are discussed.
Age-Specific Association Between Handgrip Strength and Nutritional Quality in Korean Men: A Nationwide Cross-Sectional Study
Authors: Shin Woo-young , Kim Jung-ha
Published: December 2021

This study aimed to determine the potential association between handgrip strength and nutritional quality in Korean men aged ≥20 years using data from the Korea National Health and Nutrition Examination Survey 2016 to 2018. This population-based cross-sectional study included 5,748 men aged ≥20 years. A dietary intake survey was performed using the 24-hr dietary recall method. Nutritional quality was examined using the Index of Nutritional Quality (INQ) score. A high INQ score reflected poor nutritional quality, with insufficient intake of many nutrients. Multivariate linear regression was used to determine the association between handgrip strength and INQ scores after adjusting for other covariates. The intake of carbohydrates, fiber, calcium, and vitamins B2 and C was significantly positively associated with a higher quartile for handgrip strength for those aged ≥65 years (all p < .01). A significant inverse association was found between the quartiles of handgrip strength and INQ scores among men aged ≥65 years after adjusting for all covariates (β = −0.26, p < .01). This association was not found among those aged <65 years ( p = .25). The age-specific association between handgrip strength and nutritional quality underscores the importance of public policies that promote sufficient and comprehensive nutrient intake among older adults. Handgrip strength may be useful in clinical practice as a simple and cost-effective tool for screening for nutritional quality in older adults.
Characteristics and Sexual Risk Behavior of Men Who Never Tested for HIV in Zambia
Authors: Muchimba Maureen , Zyambo Cosmas
Published: December 2021

Compared with women and girls, proportionately fewer men and boys in sub-Saharan Africa receive HIV testing, treatment, and other services. This study determined factors associated with never testing for HIV and examined never testing as a predictor of sexual risk behavior among men in Zambia. The sample included 2,609 men aged 15 to 24 from the 2018 Zambia Demographic and Health Survey. Logistic regression results revealed that compared with men who ever tested for HIV, men who never tested were more likely to be younger, have less education, have no children, be unemployed, and belong to the low wealth bracket. They also had a higher likelihood of not using a condom at last sex but were less likely to have more than five lifetime sexual partners. HIV prevention programs can use sociodemographic characteristics to identify those who have a lower likelihood of testing for HIV. Prevention programs can use sociodemographic characteristics to develop profiles of those who may especially need to be targeted by initiatives to promote HIV testing. Awareness does not always engender behavior change; therefore, in addition to knowledge of HIV status, risk reduction should also be emphasized.
Predictors of success of trial of labor after cesarean section: A nested case–control study at public hospitals in Eastern Ethiopia
Authors: Tefera Maleda , Assefa Nega , Teji Roba Kedir , Gedefa Letta
Published: December 2021

Background:

One of the primary reasons for an increase in cesarean sections is obstetricians’ uncertainty about labor trial safety following a previous cesarean section. The success rate of vaginal birth after cesarean section with a single cesarean scar is greater than 50%. However, to the best of our knowledge, there is a scarcity of information on the determinants of vaginal birth after cesarean delivery in the study area. As a result, the purpose of this study was to identify predictors of successful vaginal birth after cesarean delivery in public hospitals in Eastern Ethiopia.

Methods:

A nested case–control study design was used within a prospective follow-up study conducted from June to October 2020. A total of 220 women who tried vaginal birth after cesarean delivery was included, 110 cases and 110 controls. Cases were women with one previous cesarean section scar and successfully proceed with vaginal delivery. The controls were those with an earlier cesarean section scar and delivered by emergency cesarean section after trial of labor. A pre-tested structured questionnaire was used to gather the information. Multiple logistic regression is used to identify the determinants for the success of vaginal birth after cesarean section; odds ratio with its 95% CI are used to report the findings.

Results:

We found that living in rural areas (AOR = 2.28; 95% CI (1.85, 12.41)), having a current antenatal care follow-up (AOR = 3.20; 95% CI (1.15, 8.87)) and partograph monitoring of labor (AOR = 4.26; 95% CI (1.90, 9.57)) had a positive association with successful vaginal birth after cesarean section. In contrast, the presence of meconium-stained amniotic liquor (AOR = 0.10; 95% CI (0.01, 0.75)) and history of stillbirth (AOR = 0.07; 95% CI (0.02, 0.53)) reducing the chance of success of the trial.

Conclusion:

Past obstetric history, such as stillbirth, history of labor trial after primary cesarean section, and prior vaginal birth, were significant predictors for achieving vaginal birth after cesarean section. Antenatal care visit, and partograph follow-up were the current obstetric characteristics positively associated with the trial of labor.
Synthesis and antimicrobial activity of aryldiazenyl/arylhydrazono pyrazoles
Authors: Alsayari Abdulrhman , Asiri Yahya I , Muhsinah Abdullatif Bin , Hassan Mohd. Zaheen
Published: December 2021

We report the design, synthesis, and in vitro antimicrobial evaluation of functionalized pyrazoles containing a hydrazono/diazenyl moiety. Among these newly synthesized derivatives, 4-[2-(4-chlorophenyl)hydrazono]-5-methyl-2-[2-(naphthalen-2-yloxy)acetyl]-2,4-dihydro-3 H-pyrazol-3-one is a promising antimicrobial agent against Staphylococcus aureus (minimum inhibitory concentration 0.19 μg mL−1). Structure–activity relationship studies reveal that the electronic environment on the distal phenyl ring has a considerable effect on the antimicrobial potential of the hybrid analogues. Molecular docking studies into the active site of S. aureus dihydrofolate reductase also prove the usefulness of hybridizing a pyrazole moiety with azo and hydrazo groups in the design of new antimicrobial agents.
Online Opinion Expression about Women Serving as Judges among University Students in Egypt and Kuwait: An Integrative Study of the Spiral of Silence and Uses and Gratifications
Authors: Al-Kandari Ali A. , Frederick Edward , Hasanen Mohammed M. , Dashti Ali , Ibrahim Amal
Published: December 2021

This study integrates the Spiral of Silence and Uses and Gratifications theories to examine the willingness of university students to express on Twitter their opinions about a controversial issue, women serving as judges in Kuwait and Egypt. The analysis of a survey of 640 respondents showed that they used Twitter for information seeking, opinion formation, opinion reinforcement, and social utility in discussions, and for its democratizing capability. Democratization was the only motive to predict the expression of opinion online. When the Kuwaiti and Egyptian samples were analyzed separately, the democratization motive predicted opinion expression for the Kuwaiti students but not for the Egyptian students. Interaction effects between motivations and size of the respondent's social network on Twitter were found to predict the online expression of opinion. For example, the variable assessing the size of a respondent's social network interacted with information seeking motivation and also with opinion reinforcement to predict opinion expression online.
Can an App-Based Maxillofacial Trauma Score Predict the Operative Time, ICU Need and Length of Stay?
Authors: Singh Ashutosh Kumar , Dhungel Safal , Ahmad Zeeshan , Holmes Simon
Published: December 2021

Study Design

Retrospective chart review

Objective

Injury and trauma scores are the mainstay of predicting outcomes of trauma patients. ZS (Zeeshan and Simon) maxillofacial trauma score is based on 4 previous facial trauma scores and is user friendly, app-based visually coded facial trauma scoring system. Our study was designed to seek the application of an app-based ZS maxillofacial trauma score to predict the operative time, intensive care unit (ICU) need and length of stay.

Methods

We performed a retrospective chart review of patients who presented to a university medical college teaching hospital with maxillofacial fractures from October 2018 until October 2019. ZS maxillofacial trauma scoring app was used to calculate the ZS maxillofacial trauma severity score, which was our primary predictor variable. Our primary outcome of interest was operative time. Our secondary outcome of interest was ICU need and length of stay. Correlation analysis, linear regression and logistic regression were performed for statistical analysis. A statistical P-value of .05 was considered significant at a 95% confidence interval.

Results

There were 95 male and 5 female patients included in the study. The age ranged from 3 to 84 years with a mean of 30.76 (SD = 14.04). A statistically significant correlation between the ZS score and operative time ( r = 0.67, P < .001) was observed. ZS score predicted operative time ( b 1 = 7.67, P < .001) in our study sample . Increasing ZS trauma score was also significantly associated with ICU requirement ( X 2(3) = 13.682, P = .003), but the length of stay could not be predicted based on ZS score. Conclusions: ZS maxillofacial trauma score can predict the operative time, and an association was seen with the need for ICU with increasing ZS score, but could not predict the length of stay or the ICU need. It has potential for future integration with electronic health record systems.
Muscle volume evaluation using 3DCT for congenital clubfoot
Authors: Kakihana Masataka , Tochigi Yuki , Ozeki Satoru , Jinno Tetsuya
Published: December 2021

Background

In congenital clubfoot, the lower leg is very thin and the calf muscles are hypoplasic. However, there are few studies reporting real muscle volume.

Purpose

The purpose of this study is to assay the muscle volume in congenital clubfoot using 3DCT and to quantify the degree of the hypoplasia.

Material and methods

From January 2015 to December 2016, nine consecutive patients, seven male and two female, with unilateral congenital clubfeet were recruited for CT scans. Axial transverse sectional CT scans were acquired from the delineation of the fibular head to the tibial plafond. From the data, we rendered the entire muscle in 3D for muscle volume assay, and further segmented the posterior musculature for comparison between the normal and affected sides.

Results

The whole muscle volume on the normal side was 291.23 cm3 (181.23–593.49) and that on the affected side was 225.08 cm3 (120.71–429.08), for an affected side to normal side ratio of 0.79 (0.72–0.9), which was significantly smaller ( p < .01). Posterior muscle volume on the normal side was 175.81 cm3 (103.72–376.32) and that on the affected side was 106.52 cm3 (58.3–188.39). The ratio of posterior muscle to whole muscle on the normal side was 0.62 (0.46–0.75), and that on the affected side was 0.48 (0.4–0.55), such that the affected side was significantly smaller ( p < .01)

Conclusion

This study contributes quantitative data supporting the longstanding observations that the posterior calf muscles are significantly smaller on the affected side compared to the normal side in congenital clubfoot, and further underscores the importance of the extending the excursion of these muscles.
School Counselors’ Use of the ASCA Closing-the-Gap Action Plan Template to Address Educational Disparities
Authors: Gay Jan L. , Swank Jacqueline M.
Published: December 2021

The American School Counselor Association Closing-the-Gap Action Plan template is a tool created to help school counselors identify educational gaps and track interventions. We applied a transcendental, phenomenological qualitative research method to explore school counselors’ use of the template to advocate for students. Our findings demonstrate the rationale for using the Closing-the-Gap Action Plan template and we discuss how school counselors use it for advocacy. We also present implications for using the template as a training tool for school counselors in training.
Trajectories of Civil Society Leaders in Italy: Individual Careers, Organizational Structures, and Ideological Affiliations
Authors: Santilli Cecilia , Scaramuzzino Roberto
Published: December 2021

The aim of this paper is to explore the relationship between individual leaders’ career trajectories and organizational structure and identity in Italian civil society organizations (CSOs) active at national level. The analysis in this qualitative study draws on two sets of data, semi-structured interviews with leaders on their career trajectories and their understanding of what it takes to become a leader of a CSO and short biographies of leaders’ career trajectories. Three main representational logics are idenitified: within: multi-level, within: member-organization, and outside: supporting organization. The two first logics are based on a trajectory within the organizations either departing from the local and regional levels of the same organizations or within one or more member organizations. The third logic is based on a trajectory outside the organization that is marked by the ideological affiliation of the president through leading positions in other organizations within the same movement or field.
Settler Simultaneity and Anti-Indigenous Racism at Land-Grant Universities
Authors: Rocha Beardall Theresa
Published: December 2021

Moments of performative racial consciousness, however urgent and necessary, often fail to reckon with long-standing demands against injustice from communities of color. In the case of Indigenous Peoples in higher education, these demands frequently include an end to derogatory mascots and racialized campus violence. This article attends to those issues by merging and extending settler-colonial theory and racialized organization theory to examine how the logics of Indigenous elimination and dispossession permeate higher education. With a specific focus on land-grant universities, I argue that racialized organizations are embedded in institutional fields and that both operate within a broader settler-colonial project. I introduce the concept of settler simultaneity to further historicize the study of racialized organizations and uncover how they target persons, collectives, and ideas that pose obstacles to settler goals of subordination, extraction, and profiteering both locally and globally. I look to the University of Illinois at Urbana-Champaign as a case study that illustrates how these logics work across time and conclude by considering how critical engagement with the logics of elimination can help us to better understand, and hold accountable, the policies and programs of racialized organizations in other areas of social life.
Associations between the quality of street space and the attributes of the built environment using large volumes of street view pictures
Authors: LI Shuangjin , Ma Shuang , Tong De , Jia Zimu , Li Pai , Long Ying
Published: December 2021

In this study, we focus on the quality of street space which has attracted high attentions. We discover associations between the quality of street space and built environment attributes through an ordered logistic model using massive street view pictures (SVPs) and data on street location, form, function and attributes. Before ascertain which built environment factors influence the quality of street space, we checked the concordance of the experts’ scores, as well as correlations between different dimensions through Kappa analysis and drew the distribution map of street space quality.

We found that the value of intersection over union is 85.61% for scoring the street space quality by different people. The spatial quality of more than 75% streets are in the middle level with no obvious polarisation observed in the central area of Qingdao. In addition, for street quality index, all variables are statistically significant. The sequence is as follows: near-line rate > D/H ratio > slope > length of street > distance to administrative center > POIs diversity. The D/H ratio, near-line rate, slope length of street, distance to administrative center and POIs diversity have various associations on every dimension of street quality. They can prove useful for drafting more appropriate policy measures aimed at improving street quality.
Hydroplumboelsmoreite, (Pb1□1)Σ2(W1.33Fe3+0.67)Σ2O6(H2O), a redefined mineral species of the elsmoreite group from China
Authors: Yuan Xue , Ningyue Sun , Guowu Li , Guangming Yang
Published: December 2021

Hydroplumboelsmoreite (IMA21-C), (Pb,□)2(W,Fe3+)2O6(H2O), is a redefined elsmoreite-group mineral in the pyrochlore supergroup. It was found in a ‘jixianite’ cotype specimen provided by Mr. Liu Jianchang, who first found ‘jixianite’ in 1979 in the Jizhou District, Tianjin City, China. The mineral occurs as yellow to reddish brown aggregates, together with raspite and another elsmoreite-group mineral under study. Hydroplumboelsmoreite occurs in cryptocrystalline form and occasionally in octahedral microcrystalline form (under 20 μm in size). The crystals are colourless and translucent with a white streak, and the lustre is adamantine to greasy. Hydroplumboelsmoreite is isotropic, with a calculated refractive index of 2.29, a Mohs hardness of ~4½–5, and a calculated density of 7.47 g⋅cm−3. The strongest five powder X-ray diffraction lines [d in Å(I)(hkl)] are 6.070(28)(111), 3.012(100)(222), 2.603(32)(004), 1.836(35)(044) and 1.568(30)(226). The crystal structure was refined to R1 = 0.0459 using 80 unique reflections collected with MoKα radiation, and the results show that the mineral is cubic, space group Fd$\bar{3}$m, with a = 10.3377(5) Å, V = 1104.77(16) Å3 and Z = 8. Electron microprobe analyses and crystal structure refinement were used to determine the empirical formula: (Pb1.05Sr0.05Ce3+0.07Na0.01□0.82)Σ2.00(W1.32Fe3+0.67Zr0.01)Σ2.00O6[(H2O)0.43O0.19□0.38]Σ1.00. The mineral was named hydroplumboelsmoreite based on the predominance of Pb, W, and molecular H2O in the A, B and Y sites, respectively.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Authors: Wygrecka Malgorzata , Birnhuber Anna , Seeliger Benjamin , Michalick Laura , Pak Oleg , Schultz Astrid-Solveig , Schramm Fabian , Zacharias Martin , Gorkiewicz Gregor , David Sascha , Welte Tobias , Schmidt Julius J. , Weissmann Norbert , Schermuly Ralph T. , Barreto Guillermo , Schaefer Liliana , Markart Philipp , Brack Markus C. , Hippenstiel Stefan , Kurth Florian , Sander Leif E. , Witzenrath Martin , Kuebler Wolfgang M. , Kwapiszewska Grazyna , Preissner Klaus T.
Published: December 2021

The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. In this study, we determined the altered levels of factor XII (FXII) and its activation products in critically ill patients with COVID-19 in comparison with patients with severe acute respiratory distress syndrome related to the influenza virus (acute respiratory distress syndrome [ARDS]-influenza). Compatible with those data, we found rapid consumption of FXII in COVID-19 but not in ARDS-influenza plasma. Interestingly, the lag phase in fibrin formation, triggered by the FXII activator kaolin, was not prolonged in COVID-19, as opposed to that in ARDS-influenza. Confocal and electron microscopy showed that increased FXII activation rate, in conjunction with elevated fibrinogen levels, triggered formation of fibrinolysis-resistant, compact clots with thin fibers and small pores in COVID-19. Accordingly, clot lysis was markedly impaired in COVID-19 as opposed to that in ARDS-influenza. Dysregulated fibrinolytic system, as evidenced by elevated levels of thrombin-activatable fibrinolysis inhibitor, tissue-plasminogen activator, and plasminogen activator inhibitor-1 in COVID-19 potentiated this effect. Analysis of lung tissue sections revealed widespread extra- and intravascular compact fibrin deposits in patients with COVID-19. A compact fibrin network structure and dysregulated fibrinolysis may collectively contribute to a high incidence of thrombotic events in COVID-19.
A validated analysis pipeline for mass spectrometry-based vitreous proteomics: new insights into proliferative diabetic retinopathy
Authors: Weber Sarah R. , Zhao Yuanjun , Ma Jingqun , Gates Christopher , da Veiga Leprevost Felipe , Basrur Venkatesha , Nesvizhskii Alexey I. , Gardner Thomas W. , Sundstrom Jeffrey M.
Published: December 2021

Background

Vitreous is an accessible, information-rich biofluid that has recently been studied as a source of retinal disease-related proteins and pathways. However, the number of samples required to confidently identify perturbed pathways remains unknown. In order to confidently identify these pathways, power analysis must be performed to determine the number of samples required, and sample preparation and analysis must be rigorously defined.

Methods

Control (n = 27) and proliferative diabetic retinopathy (n = 23) vitreous samples were treated as biologically distinct individuals or pooled together and aliquoted into technical replicates. Quantitative mass spectrometry with tandem mass tag labeling was used to identify proteins in individual or pooled control samples to determine technical and biological variability. To determine effect size and perform power analysis, control and proliferative diabetic retinopathy samples were analyzed across four 10-plexes. Pooled samples were used to normalize the data across plexes and generate a single data matrix for downstream analysis.

Results

The total number of unique proteins identified was 1152 in experiment 1, 989 of which were measured in all samples. In experiment 2, 1191 proteins were identified, 727 of which were measured across all samples in all plexes. Data are available via ProteomeXchange with identifier PXD025986. Spearman correlations of protein abundance estimations revealed minimal technical (0.99–1.00) and biological (0.94–0.98) variability. Each plex contained two unique pooled samples: one for normalizing across each 10-plex, and one to internally validate the normalization algorithm. Spearman correlation of the validation pool following normalization was 0.86–0.90. Principal component analysis revealed stratification of samples by disease and not by plex. Subsequent differential expression and pathway analyses demonstrated significant activation of metabolic pathways and inhibition of neuroprotective pathways in proliferative diabetic retinopathy samples relative to controls.

Conclusions

This study demonstrates a feasible, rigorous, and scalable method that can be applied to future proteomic studies of vitreous and identifies previously unrecognized metabolic pathways that advance understanding of diabetic retinopathy.