bluuebunny/crossref_metadata_2025 huggingface dataset:
Adiponectin Levels in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Authors: Surdea-Blaga Teodora , Ismaiel Abdulrahman , Jaaouani Ayman , Leucuta Daniel-Corneliu , Elsayed Abdalla , Ismaiel Mohamed , Ben Ameur Inès , Al Srouji Nahlah , Popa Stefan-Lucian , Grad Simona , Ensar Dilara , Dumitrascu Dan L.
Published: July 2023

Introduction: Adipose tissue plays an important role in the pathogenesis of inflammatory conditions. The role of adipokines in inflammatory bowel disease (IBD) has been evaluated in the current literature with conflicting results. The aim of this study was to evaluate adiponectin levels in IBD patients, including Crohn’s disease (CD) and ulcerative colitis (UC), compared to controls, as well as further subgroup analyses. Hence, assessing the potential role of adiponectin as a surrogate marker. Methods: We performed a systematic electronic search on PubMed, Embase, Scopus, and Cochrane Library, including observational or interventional studies evaluating serum or plasma adiponectin levels in IBD patients in humans. The primary summary outcome was the mean difference (MD) in serum or plasma adiponectin levels between IBD patients versus controls. Subgroup analyses were conducted involving adiponectin levels in CD and UC compared to controls, as well as CD compared to UC. Results: A total of 20 studies were included in our qualitative synthesis and 14 studies in our quantitative synthesis, with a total population sample of 2,085 subjects. No significant MD in serum adiponectin levels was observed between IBD patients versus controls {−1.331 (95% confidence interval [CI]: −3.135–0.472)}, UC patients versus controls (−0.213 [95% CI: −1.898–1.472]), and CD patients versus controls (−0.851 [95% CI: −2.263–0.561]). Nevertheless, a significant MD was found between UC patients versus CD patients (0.859 [95% CI: 0.097–1.622]). Conclusions: Serum adiponectin levels were not able to differentiate between IBD, UC, and CD patients compared to controls. However, significantly higher serum adiponectin levels were observed in UC compared to CD patients.
A Comparative Study of Clinical and Aortic Morphological Characteristics between Bovine Aortic Arch and Normal Aortic Arch in Patients with Acute Type B Aortic Dissection
Authors: Zhang Jianhua , Zhang Anxiaonan , Wang Zhenguo , Sun Yu , Li Xiaogang , Jin Qiuyue , Shi Jinglong , Hou Jie , Zhang Libo , Yang Benqiang
Published: July 2023

Introduction: The purpose of this study was to analyze the difference in clinical and aortic morphological features between the bovine aortic arch and normal aortic arch in patients with acute type B aortic dissection (aTBAD). Methods: A total of 133 patients diagnosed with aTBAD were retrospectively collected. Based on aortic arch morphology, they were divided into the bovine aortic arch group (n = 20) and the normal aortic arch group (n = 113). Aortic morphological features were assessed on computed tomographic angiography. Clinical and aortic morphological features were then compared between the bovine aortic arch and normal aortic arch groups. Results: Patients in the bovine aortic arch group were significantly younger and with higher weight and BMI than the normal aortic arch group (p < 0.001, p = 0.045, and p = 0.016, respectively). The total aortic length in the bovine aortic arch group was significantly shorter than that in the normal aortic arch group (p = 0.039). The tortuosity of descending thoracic aorta, the tortuosity of descending aorta, and the angulation of aortic arch were significantly lower in the bovine aortic arch group (p = 0.004, p = 0.015, and p = 0.023, respectively). The width of descending aorta, the height of aorta arch, and the angle of ascending aorta were significantly smaller in the bovine aortic arch group (p = 0.045, p = 0.044, and p = 0.042, respectively). Conclusion: When the aTBAD occurred, patients with bovine aortic arch were prone to be younger and with higher BMI than those with normal aortic arch. The aortic curvature and the total aortic length were lower in patients with bovine aortic arch.
Mismatch between syntax and prosody and complex sentence structure in Hittite
Authors: Sideltsev Andrei V.
Published: July 2023

Hittite attests a set of complex sentences in which (mostly) relative clauses (other subordinate clauses are also attested) appear in linear syntax to be within another subordinate (usually conditional, rarely temporal) clause or main clause. The relative clause can be preceded by a very limited array of constituents from the matrix clause, e.g., mān ‘if’ or the quotative particle ⸗wa(r). There are also examples which attest the conditional subordinator and the irrealis particle in two positions simultaneously, at the left edge of the whole sentence and in the conditional clause (= main clause for the relative clause). I provide a fine-grained descriptive and structural analysis of the structure and show that the type cannot be explained as bare indefinites, embedded relative clauses or parenthetic clauses. It is shown that, structurally, the sentences containing subordinate (mostly relative) clauses within other clauses are heterogenous and of three types. The difference lies in the elements that precede the relative clause and in the structure of the sentences, whereby a standard Hittite relative clause adjoins at different heights. All three types display the same mismatch between prosodic domains and syntax/semantics—the constituent that is part of the main clause from the semantic and syntactic perspective is prosodically part of the relative clause. Since there is a clause boundary delimiting the end of the subordinate clause within the main clause, it makes sense to treat the surface structure as a distinct taxonomic unit, which is correspondingly labelled a mismatch sentence. The new evidence allows us to obtain a fuller understanding of the Hittite left periphery than was previously possible. It thus offers an important window into hitherto unrecognized aspects of the underlying structure of the complex sentence in Hittite.
Linking leadership development programs for physicians with organization-level outcomes: a realist review
Authors: Debets Maarten , Jansen Iris , Lombarts Kiki , Kuijer-Siebelink Wietske , Kruijthof Karen , Steinert Yvonne , Daams Joost , Silkens Milou
Published: July 2023

Background

Hospitals invest in Leadership Development Programs (LDPs) for physicians, assuming they benefit the organization’s performance. Researchers have listed the advantages of LDPs, but knowledge of how and why organization-level outcomes are achieved is missing.

Objective

To investigate how, why and under which circumstances LDPs for physicians can impact organization-level outcomes.

Methods

We conducted a realist review, following the RAMESES guidelines. Scientific articles and grey literature published between January 2010 and March 2021 evaluating a leadership intervention for physicians in the hospital setting were considered for inclusion. The following databases were searched: Medline, PsycInfo, ERIC, Web of Science, and Academic Search Premier. Based on the included documents, we developed a LDP middle-range program theory (MRPT) consisting of Context-Mechanism-Outcome configurations (CMOs) describing how specific contexts (C) trigger certain mechanisms (M) to generate organization-level outcomes (O).

Results

In total, 3904 titles and abstracts and, subsequently, 100 full-text documents were inspected; 38 documents with LDPs from multiple countries informed our MRPT. The MRPT includes five CMOs that describe how LDPs can impact the organization-level outcomes categories ‘culture’, ‘quality improvement’, and ‘the leadership pipeline’: 'Acquiring self-insight and people skills (CMO1)', 'Intentionally building professional networks (CMO2)', 'Supporting quality improvement projects (CMO3)', 'Tailored LDP content prepares physicians (CMO4)', and 'Valuing physician leaders and organizational commitment (CMO5)'. Culture was the outcome of CMO1 and CMO2, quality improvement of CMO2 and CMO3, and the leadership pipeline of CMO2, CMO4, and CMO5. These CMOs operated within an overarching context, the leadership ecosystem, that determined realizing and sustaining organization-level outcomes.

Conclusions

LDPs benefit organization-level outcomes through multiple mechanisms. Creating the contexts to trigger these mechanisms depends on the resources invested in LDPs and adequately supporting physicians. LDP providers can use the presented MRPT to guide the development of LDPs when aiming for specific organization-level outcomes.
Nutritional, health and socio-demographic determinants of anaemia in adolescent girls in Kumbungu District, Ghana
Authors: Wemakor Anthony , Kwaako Matilda , Abdul-Rahman Adinan
Published: July 2023

Background

Anaemia is a serious health problem among adolescent girls in Ghana. The aims of this study were to measure the prevalence and identify the nutritional, health, and socio-demographic determinants of anaemia in adolescent girls in Kumbungu District, Northern Region, Ghana.

Method

An analytical cross-sectional study involving 370 adolescent girls residing in Kumbungu district, selected using multi-stage sampling procedure, was conducted. A semi-structured questionnaire, 24-hr dietary recall, food frequency questionnaire, Food Insecurity Experience scale, and anthropometry were used to gather information on socio-demographic characteristics, nutrition knowledge, dietary diversity score, food consumption score, food consumption frequency, household food insecurity, and waist and hip circumferences. Haemoglobin was measured using a portable HemoCue hg 301 + Analyzer. Anaemia in the adolescent girls was defined as haemoglobin concentration less than 12 g/dl. Chi-square test and binary logistic regression analysis were used to identify the determinants of anaemia.

Results

The mean (± SD) age was 13.95 (± 2.94) years, and the majority of the girls were in school (79.5%) and lived in a rural area (81.1%). The mean (± SD) haemoglobin was 11.27 (± 1.19) g/dl, and 74.6% of the respondents had anaemia, with 1.6% having severe anaemia. The health determinant of anaemia was frequency of feeling nervous in the past 6 months [Adjusted Odds Ratio (AOR): 2.12: 95% Confidence Interval (CI): 1.17–3.89; p: 0.014], and the socio-demographic determinants were residential community status (AOR: 0.42; 95% CI: 0.24–0.75; p: 0.003), and fathers’ educational qualification (AOR: 2.57, 95% CI: 1.17–5.65, p: 0.019). No nutritional determinants of anaemia were identified for this study population.

Conclusion

The prevalence of anaemia was very high and the frequency of feeling nervous in the past 6 months, residential community status, and fathers’ educational qualification were associated with anaemia among adolescent girls in Kumbungu district, Ghana. The prevalence of anaemia measured highlights the need for intensification of anaemia prevention and management interventions in the district.
Does Low-Grade Versus High-Grade Bilsky Score Influence Local Recurrence and Overall Survival in Metastatic Spine Tumor Surgery?
Authors: Bendfeldt Gabriel A. , Chanbour Hani , Chen Jeffrey W. , Gangavarapu Lakshmi Suryateja , LaBarge Matthew E. , Ahmed Mahmoud , Jonzzon Soren , Roth Steven G. , Chotai Silky , Luo Leo Y. , Abtahi Amir M. , Stephens Byron F. , Zuckerman Scott L.
Published: July 2023

BACKGROUND AND OBJECTIVES:

Spinal cord compression caused by spinal tumors is measured using the epidural spinal cord compression scale, also known as the Bilsky score. Whether Bilsky score predicts short-/long-term outcomes remains unknown. The objectives were to determine the correlation of Bilsky score 0–1 vs 2–3 with regards to (1) preoperative presentation, (2) perioperative variables, and (3) long-term outcomes.

METHODS:

A single-center, retrospective evaluation of a cohort of patients undergoing metastatic spine surgery was performed between 01/2010 and 01/2021. Multivariable logistic/linear/Cox regression were performed controlling for age, body mass index, race, total decompressed levels, tumor size, other organ metastases, and postoperative radiotherapy/chemotherapy.

RESULTS:

Of 343 patients with extradural spinal metastasis, 92 (26.8%) were Bilsky 0–1 and 251 (73.2%) were Bilsky 2–3. Preoperatively, patients with Bilsky 2–3 lesions were older (P = .008), presented more with sensory deficits (P = .029), and had worse preoperative Karnofsky Performance Scale (KPS) (P = .002). Perioperatively, Bilsky 2–3 patients had more decompressed levels (P = .005) and transpedicular decompression (P < .001), with similar operative time (P = .071) and blood loss (P = .502). Although not statistically significant, patients with Bilsky 2–3 had more intraoperative neuromonitoring changes (P = .412). Although rates of complications (P = .442) and neurological deficit (P = .852) were similar between groups, patients with Bilsky 2–3 lesions had a longer length of stay (P = .007) and were discharged home less frequently (P < .001). No difference was found in 90-day readmissions (P = .607) and reoperation (P = .510) Long-term: LR (P=.100) and time to LR (log-rank; P=0.532) were not significantly different between Bilsky 0-1 and Bilsky 2-3 lesions. However, patients with Bilsky 2–3 lesions had worse postoperative KPS (P < .001), worse modified McCormick scale score (P = .003), shorter overall survival (OS) (log-rank; P < .001), and worse survival at 1 year (P = .012). Bilsky 2–3 lesions were associated with shorter OS on multivariable Cox regression (hazard ratio = 1.78, 95% CI = 1.27-2.49, P < .001), with no significant impact on time to LR (hazard ratio = 0.73, 95% CI = 0.37-1.44, P = .359).

CONCLUSION:

Bilsky 2–3 lesions were associated with longer length of stay, more nonhome discharge, worse postoperative KPS/modified McCormick scale score, shorter OS, and reduced survival at 1 year. Higher-grade Bilsky score lesions appear to be at a higher risk for worse outcomes. Efforts should be made to identify metastatic spine patients before they reach the point of severe spinal cord compression..
Sobre el principio de proporcionalidad. Una discusión con Horacio Spector
Authors: Spector, Horacio
Published: July 2023

Discusión en el Seminario de Teoría del Derecho y Lógica de Normas «Carlos Alchourrón y Eugenio Bulygin» sobre el texto “Proporcionalidad constitucional y el teorema de Alchourrón-Makinson”.
Development of nano-PDLCs with low haze
Authors: Redding Megan , Mostafa Md , Jákli Dr. Antal , West Dr. John
Published: July 2023

Nano-PDLCs consist of nano-sized liquid crystal droplets suspended in a UV-curable optical adhesive polymer. These polymer matrices are stable, optically isotropic, and voltage sensitive which make them ideal for the further development of diffraction gratings and lenses with variable focal length (VFL). However, haziness causes application limits. This research serves to optimize curing parameters and switching times while limiting the amount of haze present in these cells.
OKUL ÖNCESİ EĞİTİM PROGRAMINDA REGGİO EMİLİA YAKLAŞIMI
Authors: UZAN Sümeyya
Published: July 2023

Reggio Emilia yöntemi erken çocukluk eğitimi için alternatif yöntemlerden biridir. Yapılandırmacı pedagojik teoriler, sosyoloji ve pedagojik eleştiriye göre eğitimin savunulduğu bu yaklaşımda çocuklar, ilgili konularda araştırma yaparak, ilgilerini çeken konularda projeler üreterek, yaparak yaşayarak bilgiyi yapılandırırlar ve zengin ortamlarda yaşamak, becerileri bilimsel süreçlerde kullanmak, görsel sanatlar ve oyunlar gibi farklı yöntemler kullanırlar. Türkiye'de son yıllarda yaygın olarak kullanılmasına rağmen uygulamaları konusunda yeterli araştırma yapılmamıştır. Bu çalışmada, Reggio Emilia erken çocukluk eğitimi yaklaşımının Türkiye'deki mevcut Okul Öncesi Eğitim programına yansımasının incelenmesi amaçlanmıştır. Bu anlamda nitel araştırma yöntemlerinden doküman incelemesi tekniği kullanılmıştır.
Theoretical exploration of low GWP refrigerant mixtures as replacement to HFC-134A in a vapour compression refrigeration system
Authors: HASHEER SK Mohammed , KOLLA Srinivas , KONDALA RAO Dasari , NAGA VENKATA SAI RAM Yellapragada
Published: July 2023

Hydro-fluorocarbons (HFCs) that are not harmful to ozone layer and are used in many appli-cations, including as refrigerants, aerosols, solvents and blowing agents for insulating foams replace chlorofluorocarbons and hydro chlorofluorocarbons (HCFCs). However, some HFCs have a high GWP, which stands for “Global Warming Potential(GWP).” Because of the grow-ing concern over global climate change, researchers are paying closer attention for alternatives to these HFCs. The main focus of this work was on the theoretical analysis of the refrigerant mixtures namely AC5, R430A, and R440A as direct replacements for HFC-134a in a refriger-ator. The performance of the refrigerator may be enhanced using heat exchanger. The com-pressor discharge temperature, COP, VCC, refrigerant mass flow rate, power consumption of a compressor and pressure ratio were used to measure the performance of a home refrigerator. The typical COP of R440A and R430A was about 2.5% and 1.4% higher than that of HFC-134, while the average COP of AC5 was 6.1% lesser than that of HFC-134a. R430A almost has the same VCC (Volumetric Cooling Capacity) as HFC-134a. The results also show that HFC-134a uses more power than AC5, R440A, and R430A. R440A and AC5 have higher compressor outlet temperatures than HFC-134a, which affects the life span of the compressor. In com-parison with all the above refrigerants, R430A gives the best overall performance and used as replacement to HFC-134a in a VCR.
Two Decades of Democracy in Nigeria: Between Consolidation and Regression
Authors: Ashindorbe Kelvin , Danjibo Nathaniel
Published: July 2023

The year 1999 marked a watershed moment in the political history of Nigeria with the transition from military to civilian rule and the beginning of the Fourth Republic. Two decades later, the country has not only witnessed the longest period of civilian democratic rule but has also achieved a milestone with the alternation of power between the two dominant political parties. The augury, however, points to a democracy oscillating between consolidation and regression. This paper therefore interrogates two decades of democratisation in Nigeria in the context of the two main parties, the conduct of elections, and the level of representation of marginalised groups, particularly women. The paper contends that while it may be uncharitable to discount the incremental gains since the return to civil rule, the country is far from attaining the status of a consolidated democracy.
Efficacy of Rubella Vaccine after Co-Inoculation with RHOGAM
Authors: Brunton Joshua , Theiler Regan , Mehta Ramila , Branda Megan E. , Enninga Elizabeth Ann , Torbenson Vanessa E.
Published: July 2023

Abstract
Congenital rubella syndrome is a constellation of birth defects that can have devastating consequences, impacting approximately 100,000 births worldwide each year. The incidence is much lower in countries that routinely vaccinate their population. In the US, postnatal immunization of susceptible women is an important epidemiological strategy for the prevention of rubella. However, concerns that co-administration of Rubella vaccine with other immunoglobins (i.e., Rhogam) could comprise vaccine efficacy has produced warnings that can delay the administration of Rubella vaccination postpartum, leaving women susceptible in a subsequent pregnancy. We aimed to address whether co-administration of Rubella vaccine and Rhogam decreased antibody responses as compared to those receiving only Rubella vaccination. This retrospective cohort study utilized clinical data from 80 subjects who received Rubella vaccine and Rhogam after delivery and 43 subjects received Rubella vaccine alone. Maternal demographics, pregnancy complications and rubella status at the start of a subsequent pregnancy were recorded for analysis. Overall, the two cohorts had similar baseline characteristics; however, lower parity was noted in the participants having both Rubella vaccination and Rhogam. Based on maternal antibody IgG index for rubella during the next pregnancy, we observed that 88% of the Rhogam + Rubella vaccine group had positive titers, which was not significantly different than the 81% in the Rubella vaccine only cohort (p=0.36). In conclusion, no differences in the rubella immunity status in a subsequent pregnancy were observed in those mothers administered both Rubella vaccine and Rhogam concurrently. Given these findings, warnings against co-administration of Rubella vaccine in combination with other immunoglobulins should be discontinued.
Unraveling the Role of Metals and Organic Acids towards Bacterial Antimicrobial Resistance in the Food Chain
Authors: Rebelo Andreia , Almeida Agostinho , Peixe Luísa , Antunes Patrícia , Novais Carla
Published: July 2023

Antimicrobial resistance (AMR) has a significant global impact on human, animal, and environmental health. Misuse and overuse of antibiotics in clinical and animal production settings are the main drivers behind the emergence of antimicrobial resistant bacteria. However, other compounds with antimicrobial activity may also contribute to this global public health problem. The aim of this comprehensive review is to provide detailed insights into the impact of metals and organic acids on the emergence and spread of AMR in the food chain, for which their role is not fully understood. The review examines the widespread use of organic acids in the food industry as feed additives or disinfectants, the crucial role of copper in animal growth and the harmful effects of mercury and arsenic as pollutants in food-producing environments. Additionally, it explores the antimicrobial mechanisms of metals and organic acids, the tolerance mechanisms developed by bacteria, and the interplay between genes responsible for metal tolerance and AMR. The comprehensive and integrated data presented highlights the need to further explore and understand the role of metals and organic acids as drivers of AMR to develop well-defined strategies effectively mitigating the AMR crisis within the food chain context.
Development and Initial Characterisation of a Localised Elastin Degradation Ex Vivo Porcine Aortic Aneurysm Model
Authors: Laffey Matthew , Tornifoglio Brooke , Lally Caitríona
Published: July 2023

Aortic aneurysms (AA) occur in 4.8% of people causing 150,000 deaths annually. While endovascular aneurysm repairs reduce surgical morbidity, device-related failures (leak/displacement) are frequent highlighting the need for test models that better represent the mural geometry and compliance changes in human AAs. We aimed to develop and characterise an ex vivo porcine aortic model of AA. The optimal duration of tissue elastase exposure to emulate AA changes in elastin microstructure and content was determined using porcine aortic rings. Elastase-induced changes were quantified morphologically, and mechanical properties assessed via ring tensile testing. Subsequent experiments tested the potential for localised elastase treatment in a 1 cm segment of porcine aorta using a specially designed 3D printed test rig. The effect on pressure-diameter behaviour was investigated via inflation-extension testing. Elastase treatment produced time dependent decreases in elastin, resulting in an increased tensile modulus and circumferential length in the ring samples in the final phase of the J-shaped tissue stress-strain curves. In whole aortic segments, localised elastase-induced luminal degradation was successfully limited to a central region. The degree of elastin degradation achieved was sufficient to cause localised dilation with respect to controls under physiological pressures. Localised elastin degradation in porcine aortic segments is feasible and emulates the changes seen clinically in aortic aneurysms.
Knowing Is Better Than Wondering. The Cataloging of Natural Heritage between Museum Studies and Forensic Sciences
Authors: Franza Annarita , Scali Federica , Garofano Luciano , Pratesi Giovanni
Published: July 2023

This paper aims to analyze the role of natural heritage cataloging when criminal events challenge natural history museums. This study investigates the rhino horn thefts in Italian natural history museums from 2011 to 2015 to provide a comprehensive framework for these robberies while highlighting the weaknesses and strengths to prevent thefts and safeguard both rhino horns and natural history collections from future targeting
Energy Usage, Health Issues, and Pro-Environmental Behaviour: Exploring the Link and Promoting Energy Change in Kyrgyzstan
Authors: Hamelin Nicolas , Bhatti Muhammad Ishaq
Published: July 2023

Background: This study examines the relationship between energy usage, health issues, and pro-environmental behavior (PEB) in Kyrgyzstan, amidst the country's commitment to transition from coal-based energy to renewable sources in line with the Paris Agreement. The purpose is to investigate citizens' attitudes towards PEB and their intentions to engage in environmentally friendly actions, focusing on gas, electricity, and coal. Methods: Drawing upon the Theory of Planned Behavior (TPB) framework, a survey was conducted among 1,455 respondents to explore attitudes towards PEB and energy sources' impact on health issues. Results: Decarbonization efforts in Kyrgyzstan and Central Asia are in their early stages, with coal remaining a primary energy source. The study emphasizes the importance of governmental policies and citizen action in achieving decarbonization goals. Rising electricity costs outweigh the increase in indirect energy costs for food, posing challenges for households in adapting to changing energy dynamics. Conclusions: Targeted interventions and communication strategies are crucial to promote pro-environmental behavior and facilitate the transition to sustainable energy sources. Understanding the relationships between health concerns, air pollution awareness, PEB, and energy source choices can inform policymakers and organizations in their efforts to ensure a sustainable and healthy future for Kyrgyzstan and other Central Asian countries.
A Comparison of Clinical Outcomes Associated with Dosing Metronidazole Every 8 Hours Versus Every 12-Hours: A Systematic Review and Meta-Analysis
Authors: Jizba Theresa , Ahmad Faran , Walters Ryan W , Foral Pamela , Destache Christopher J , Velagapudi Manasa
Published: July 2023

Background. Metronidazole treats obligate anaerobic bacterial and protozoal infections, with an elimination half-life of around eight hours. The long elimination half-life, the favorable ratio of steady-state serum levels to minimum inhibitory concentration, and the presence of active metabolites lead to consideration of metronidazole use at 12-hour dosage intervals. This systematic review aimed to compare the clinical outcomes of twice-daily and thrice-daily metronidazole dosing. Methods. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. PubMed, Scopus, Science Direct, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials to systematically identify all relevant studies published up to June 16, 2023. Results. The final analysis included two published retrospective cohort studies; a single site (n = 200) and a multisite study (n = 85) of ‘good’ quality, as measured by the Newcastle-Ottawa scale. The reported baseline characteristics of the 8-hour and 12-hour dosing groups were comparable, and neither study identified significant differences in primary and secondary clinical outcomes. Meta-analysis of the need to escalate antibiotic therapy also showed no statistically significant differences using the Mantel-Haenszel fixed-effect method (95% CI: 47.6% lower to 6.4 times higher risk, p = 0.342) and inverse-variance method (RR: 1.87, 95% CI: 0.52-6.65, p = 0.336). Conclusions. Dosing metronidazole every 12 hours is as effective as every 8-hour dosing for anaerobic infections. Healthcare systems may consider the adoption of every 12-hour metronidazole dosing with continued evaluation of patient outcomes.
The Facilitators and Barriers to Home-based Robotic Rehabilitation in India: A pilot feasibility study
Authors: Nehrujee Aravind , Prabhakar AT , Balaraman Sathish , Bombatkar Rasika , Prakash Henry , SamuelKamaleshKumar S , Aaron Sanjith , Bhattacharya Suranjan , Srinivasan Sujatha , Balasubramanian Sivakumar
Published: July 2023

Robot-assisted rehabilitation has emerged as a promising approach for enhancing motor function in stroke survivors. However, the feasibility and effectiveness of home-based robotic training in this population are underexplored, especially in low/middle-income countries. This feasibility study aimed to address this gap by examining the feasibility and effectiveness of independent home-based training using PLUTO, a robotic device for hand training. A total of 7 chronic stroke survivors were recruited, with 5 completing the study. The results revealed high engagement and adherence to the home-based training program, with participants averaging 1659.8 minutes of training over 24.8 days. The PLUTO system demonstrated excellent usability and elicited positive user perceptions. Significant improvements were observed in functional outcomes, as evidenced by a noteworthy increase in Fugl-Meyer Assessment scores (mean increase of 6.2 points, exceeding the minimal clinically important difference (MCID) of 5.35 points). Furthermore, participants showed improvements in the ABILHAND measure (mean improvement of 1.24 logits, surpassing the MCID of 0.2 logits) and the Barthel Index (mean increase of 8.8 points). These findings demonstrate the feasibility and effectiveness of home-based robotic rehabilitation for chronic stroke survivors. This has implications for expanding access to rehabilitation services in low- and middle-income countries, enhancing patient engagement and adherence, and improving functional outcomes. Larger controlled studies are warranted to evaluate the effectiveness of home-based robotic rehabilitation programs.
A Sensitive Monoclonal Antibody B4Mab-7 against EphB4 Was Developed for Breast Cancers
Authors: Nanamiya Ren , Suzuki Hiroyuki , Kaneko Mika K. , Kato Yukinari
Published: July 2023

The erythropoietin-producing hepatocellular carcinoma (Eph) receptors are the largest receptor tyrosine kinases family. EphB4 is essential for cell adhesion and motility during embryogenesis. Pathologically, EphB4 is overexpressed and contributes to poor prognosis in various tumors. Therefore, sensitive monoclonal antibodies (mAbs) should be developed to predict the prognosis for multiple tumors with high EphB4 expression, including breast and gastric cancers. This study aimed to develop highly sensitive and specific anti-EphB4 mAbs for several applications using the Cell-Based Immunization and Screening (CBIS) method. EphB4-overexpressed Chinese hamster ovary (CHO)-K1 (CHO/EphB4) cells were immunized into mice, and we established an anti-EphB4 mAb (clone B4Mab-7), which is applicable for flow cytometry, western blotting, and immunohistochemistry. B4Mab-7 reacted with endogenous EphB4-positive breast cancer cell lines, MCF-7 and MDA-MB-468, but did not react with EphB4-knockout MCF-7 (BINDS-52) in flow cytometry. Dissociation constant (KD) values were determined to be 2.9 × 10‑9 M, 1.3 × 10‑9 M, and 3.3 × 10‑9 M by flow cytometric analysis for CHO/EphB4, MCF-7, and MDA-MB-468 cells, respectively. B4Mab-7 detected the EphB4 protein bands from breast cancer cells in western blotting, and stained breast cancer tissues immunohistochemistry. Altogether, B4Mab-7 demonstrated high sensitivity and specificity against EphB4 in various applications.
A Review on Friction Stir Welding: Numerical Modeling
Authors: Akbari Mostafa , Asadi Parviz , Sadowski Tomasz
Published: July 2023

Employing numerical methods to simulate manufacturing processes and study their influential factors is increasing. The development of computers and engineering software has increased the ability and accuracy of numerical methods in simulating various aspects of different processes. One of the manufacturing processes that has been considered by many industries in recent years to join metals in solid-state with unique properties is called friction stir welding. It is challenging and, in some cases, impossible to experimentally study the various aspects of this process, such as temperature distribution, stress distribution, and material flow, due to severe plastic deformation in the weld zone. In this case, numerical methods are used to investigate these parameters and better understand the process. This study first investigates various numerical methods researchers use to simulate the process. The ability, pros, and cons of these methods to simulate the process are also examined. Then, the applications of numerical models in simulating the temperature distribution during the process as well as the effects of input parameters on the temperature history of the process, are deeply considered. Next, the application of numerical methods in material flow modeling during the process is investigated. Finally, the modeling of the microstructure of the welding zone is investigated using numerical methods that help significantly in predicting the weld microstructure.
Artificial Intelligence in Environmental Monitoring: Application of Artificial Neural Networks and Machine Learning for Pollution Prevention and Toxicity Measurements
Authors: Szramowiat-Sala Katarzyna
Published: July 2023

Environmental monitoring systems play a crucial role in assessing environmental quality, detecting limits exceedances, and predicting potential ecological episodes. These systems rely on the measurement of various variables at specific locations and time intervals over an extended period. The concept of environmental monitoring encompasses the assessment of health and safety issues for public and environmental health purposes. Pollution of the atmosphere and water, climate change, and natural disasters are among the consequences of continuous industrial and municipal development and human interference in natural ecosystems. To address these challenges and to protect human lives and the environment, with a special concern on mitigating the ecological effects of industrial development, advanced technical solutions, including the technologies associated with artificial intelligence (artificial neural networks ANNs, machine learning ML) have been developed. These technologies offer powerful tools for analysing the vast amount of data collected by monitoring systems and extracting valuable insights. By applying ANNs and machine learning algorithms, environmental monitoring systems can effectively process and interpret the measured variables to assess environmental quality. Despite challenges and limitations, such as data quality and interpretability of AI models, ongoing research and interdisciplinary collaboration are paving the way for the successful implementation of AI in environmental monitoring, ultimately supporting informed decision-making and sustainable resource management.While several review papers have explored the theory of artificial intelligence (AI), here I aim to review the application of ANNs and ML, in environmental aspects, specifically in automotive and industrial emissions toxicity measurements, as well as atmospheric pollution prevention. By examining the potential of AI in these domains, the paper contributes to understanding the role of advanced technologies in environmental monitoring and protection.
From Synthalin to Metformin:is a Century Cycle of Biguanides as Oral Antidiabetic drugs Now Closed?
Authors: Ramadori Giuliano Pasquale
Published: July 2023

After the first release of synthalin B (dodecamethylenbiguanide) in 1928 and its later retraction in the 1940s in Germany and the retraction of phenformin (N-Phenethylbiguanide) because of the letal complication of acidosiss,metformin (1-1-dimethylbiguanide) was first released in France in 1959 and then in the USA in 1995 for oral treatment of diabetes type 2.
Acute gastrointestinal side effects often lead to dose reduction and strongly limit adherence to therapy.Main long-term consequences are deficency of vitamin B12 and of iron and sometimes also acidosis development.
Intravenously injected F18-labelled glucose in metformin-treated type 2 diabetics accumulates in the the small and even more in the large intestine.The densitometry picture observed in metformin-treated diabetics is similar to that observed in patients after bowel-cleansing or chronically taking different types of laxatives where the accumulated radioactivity can even reach values observed in colon cancer.
The glucose-lowering mechanism of action of metformin is therefore not only due to inhibition of glucose uptake in the small intestine but also to „attraction“ of glucose from the hepatocyte to the intestine,possibly through its secretion into the bile.Metformin is not different from the other biguanides ,synthalin B and phenformin.The mechanism of action,and the side effects are comparable to those of laxatives.
Vaccination Problem: Matching Theory Approach in Vaccination Against Coronavirus
Authors: Askari Harooni Hamid , Eshaghi Gordji Madjid
Published: July 2023

In this article, ‎we examine an allocation issue faced by European Health Union (EHU)‎. ‎Given this situation, ‎we introduce the issue of vaccine selection. ‎The model proposed in this paper helps to implement vaccination optimally using matching theory. ‎By adopting the mechanism presented in this article, ‎this is done more easily and more quickly, ‎so that mortality in society is lower and public satisfaction is increased. ‎This is similar to the issues analyzed in the literature on the design mechanism of non-perishable goods.
One-Pot Sol-Gel Synthesis of Highly Insulative Hybrid P(AAm-Co-AAc)-Silica Aerogels with Improved Mechanical and Thermal Properties
Authors: Ransing Akshay A. , Dhavale Rushikesh P. , Parale Vinayak G. , Bangi Uzma K.H. , Choi Haryeong , Lee Wonjun , Kim Jiseung , Wang Qi , Phadtare Varsha D. , Kim Taehee , Jung Wook Ki , Park Hyung-Ho
Published: July 2023

Silica aerogels and their derivatives have outstanding thermal properties with exceptional values in the thermal insulation industry. However, the brittle nature restricts its large-scale commercialization. Thus, enhancing their mechanical strength without affecting their thermal insulating properties is essential. Therefore, for the first time, highly thermally stable Poly(acrylamide-Co-acrylic acid) partial sodium salt is used as a reinforcing polymer to synthesize hybrid P(AAm-CO-AAc)-silica aerogels via epoxy ring-opening polymerization in the present study. Functional groups in P(AAm-CO-AAc) partial sodium salts, such as CONH2 and COOH, acted as nucleophiles for the epoxy ring-opening reaction with (3-glycidyloxypropyl)trimethoxysilane, which resulted in a seven-fold enhancement in mechanical strength compared to that of a pristine silica aerogel while maintaining the thermal conductivity at less than 30.6 mW/mK and porosity of more than 93.68%. Moreover, the hybrid P(AAm-CO-AAc)-silica aerogel demonstrated improved thermal stability up to 343 ⁰C owing to the synergetic effect between P(AAm-CO-AAc) and the silica aerogel, corresponding to thermal stability and strong covalent bonding among them. These excellent results illustrate that this new synthetic approach for producing hybrid P(AAm-CO-AAc)-silica aerogels is useful for enhancing the mechanical strength of a pristine silica aerogel without impairing its thermal insulating property and shows potential as an industrial heat insulation material.
Plant Nitrogen Estimation by Developing an Accurate Correlation Between VNIR-Only Vegetation Indexes and Normalized Difference Nitrogen Index
Authors: Çimtay Yücel
Published: July 2023

Nitrogen is crucial for plant physiology due to the fact that plants consume a significant amount of nitrogen during the development period. Nitrogen supports the root, leaf, stem, branch, shoot and fruit development of plants. At the same time, it also increases flowering. To monitor the vegetation nitrogen concentration, one of the best indicator developed in the literature is Normalized Difference Nitrogen Index (NDNI) which is based on the usage of the spectral bands: 1510 and 1680 nm. from Short-Wave Infrared (SWIR) region of electromagnetic spectrum. However, majority of the remote sensing sensors like cameras and/or satellites do not have a SWIR sensor due to the high costs. Many vegetation indexes like NDVI, EVI, MNLI, have been developed in also VNIR region to monitor the greenness and healthy of the crops. However these indexes are not very correlated to the nitrogen content. Therefore, in this study, a novel method is developed which transforms the estimated VNIR band indexes to NDNI by using a regression method between a group of VNIR indexes and NDNI. Training is employed by using VNIR band indexes as input and NDNI as output which are both calculated from the same location. After training, 0.93 correlation is achieved. Therefore, by using only VNIR band sensors, it is possible to estimate the nitrogen content of the plant with high accuracy.
Spectral Applications of Vertex-Clique Incidence Matrices Associated with a Graph
Authors: Fallat Shaun , Mojallal Seyed Ahmad
Published: July 2023

In this paper, we demonstrate a useful interaction between the theory of clique partitions, edge clique covers of a graph, and the spectra of graphs. Using a clique partition and an edge clique cover of a graph we introduce the notion of a vertex-clique incidence matrix for a graph and produce new lower bounds for the negative eigenvalues and negative inertia of a graph. Moreover, utilizing these vertex-clique incidence matrices, we generalize several notions such as the signless Laplacian matrix, and develop bounds on the incidence energy and the signless Laplacian energy of the graph.
%The tight upper bounds for the energies of a graph and its line graph are given.
More generally, we also consider the set $S(G)$ of all real-valued symmetric matrices whose off-diagonal entries are nonzero precisely when the corresponding vertices of the graph are adjacent. An important parameter in this setting is $q(G)$, and is defined to be the minimum number of distinct eigenvalues over all matrices in $S(G)$. For a given graph $G$ the concept of a vertex-clique incidence matrix associated with an edge clique cover is applied to establish several classes of graphs with $q(G)=2$.
Taxonomic Comparison, Antioxidant and Antibacterial Activities of Three Ecotypes of Ebenus pinnata Ait. (Fabaceae) from Algeria
Authors: Zemouri Tassadit , Chikhoune Amirouche , Benmouhoub Hassina , Sahnoune Mohamed
Published: July 2023

The North African E. pinnata is not known as a traditional medicinal plant but modern research has revealed its extracts richness in anti-oxidants and components of medicinal value. Despite its wide distribution and medicinal value, the species remains taxonomically and phytochemically un-derstudied, especially in Algeria. Here we compare three ecotypes of E. pinnata from the humid, sub-humid and semi-arid areas. The comparison was carried out using classical techniques of multivariate plant morphology, pollen grains size and shape, chromosome numbers, pollen fer-tility, anti-oxidant and antibacterial activities. Significant differences were revealed for all criteria except pollen fertility and antibacterial activity. The semi-arid ecotype showed to be a remote group in relation to the two others except for pollen size where the remote group was the sub-humid ecotype. Pollen size appeared positively correlated with karyotype length. The results (mg GAE/g EXT) of the antioxidant activity tests of the “humid”, “sub-humid” and the “semi-arid” plant groups are as follows, respectively; TPC: 50.79±0.51, 52.04±1.05 and 56.89±0.46; DPPH: 71.18±2.24, 86.39±3.02 and 95.67±2.02; RP: 11.09±1.24, 17.21±0.75 and 25.88±0.26. The inhibition area diameter in the antibacterial activity test varied from 9.25±1.06 mm (Semi-arid plants vs Pseudo-monas aeruginosa) to 12.00±1.41 mm (Sub-humid plants vs Escherichia coli).
A Model Calibration Approach to U-value Measurements with Thermography
Authors: Patel Dhruvkumar , Estevam Schmiedt Jacob , Röger Marc , Hoffschmidt Bernhard
Published: July 2023

The thermal properties of a building envelope are key indicators of the energy performance of the building. Therefore, methods are needed to determine quantities like U-values or heat capacitance in a fast, reliable way and with as little impact on the use of the building as possible. In this paper a technique is proposed that relies on a simplified electrical analogical model of building envelope components which can cover their dynamic thermal behavior. The parameters of this model are optimized to produce the best fit between simulated and measured outside surface temperatures. As the temperatures can be measured remotely with an infrared camera this approach requires significantly less installation effort and intrusion in the building than other methods. At the same time, a single measurement provides data for a large range of locations on a facade or a roof. The paper describes the method and a first experimental implementation of it. The experiment indicates that this method has the potential to produce results which have an accuracy that is comparable to standardized reference methods.
The Self-Confidence among Those with High Musical Abilities Student
Authors: Hammouri Khalid
Published: July 2023

The purpose of the current study was the level of the self-confidence among with high musical abilities Student? The randomly selected sample consisted of students (n= 130, M= 65, F= 65) . The analytical descriptive approach was applied in the study and self-confidence Scale developed by the author was administered to participants. Results indicated that: - The self-confidence among the high musical abilities Student students was rated high. There were no statistically significant differences at (α=≤0.05) attributed to effect of sex on the self-confidence overall degree. There were statistically no significant differences at (α≤0.05) attributed to effect of achievement on the self-confidence overall degree,
Philosophical Horizons: Navigating the Frontiers of 21st Century Arts and Sciences Education
Authors: Eslit Edgar
Published: July 2023

This qualitative study conducted at St. Michael's College explores the integration of philosophical dimensions in arts and sciences education and its implications for pedagogy and student learning. Drawing on three theoretical framework informed by Piaget, Sartre, and Vigotsky, the study examines the perspectives of 30 participants, including teachers and students, through semi-structured interviews. The findings reveal diverse viewpoints, with some participants emphasizing disciplinary specialization for focused skill development, while others advocate for integrating philosophical dimensions to enhance critical thinking, interdisciplinary connections, and ethical awareness. The implications highlight the importance of balancing disciplinary depth with interdisciplinary exploration in arts and sciences education. Educators are encouraged to recognize the value of disciplinary specialization while integrating philosophical dimensions to foster critical thinking skills, interdisciplinary connections, and ethical awareness among students. Recommendations include providing professional development opportunities for educators, incorporating philosophical perspectives in curriculum frameworks, and exploring the long-term impact of integrating philosophical dimensions on student learning outcomes. Future research should investigate specific pedagogical approaches, consider cultural and contextual factors, and further explore the impact of integrating philosophical horizons to advance educational practices. By embracing the integration of philosophical dimensions, educators can create meaningful learning experiences that promote critical thinking, interdisciplinary connections, and ethical awareness in arts and sciences education.