bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Pars Plana Vitrectomy in the Diagnosis and Treatment of Uveitis
Authors: Svozilkova Petra , Heissigerova Jarmila , Bhchova Michaela , Kalvodova Bohdana , Dvorak Jan , Rihova Eva
Published: November 2010

Purpose

TO assess the diagnostic yield of vitreous fluid analysis and the therapeutic effect of pars plana vitrectomy in patients with suspected intraocular inflammation.

Methods

During 2004–2008, pars plana vitrectomy was performed in 89 patients (101 eyes) out of 1233 patients with uveitis. Vitreous specimens were analyzed by cytologic and histopathologic examination, microbiologic culture, polymerase chain reaction, antibody determination, and flow cytometry. Vitrectomy was performed in 85 eyes for both diagnostic and therapeutic purposes; the remaining 16 eyes underwent only diagnostic pars plana vitrectomy. Preoperative and postoperative best-corrected Snellen visual acuity was compared.

Results

Preoperative diagnoses were infection in 40 patients, malignant masquerade syndrome in 10 patients, and idiopathic uveitis in 39 patients. Vitreous analysis contributed to the determination of diagnosis in 54 patients (61%). Final diagnoses were infection in 42 patients, malignant masquerade syndrome in 6 patients, benign masquerade syndrome in 16 patients, and idiopathic uveitis in 25 patients. Vitreous fluid collected from each eye underwent approximately 2.2 (range 1–6) laboratory tests. Therapeutic reasons for vitrectomy were the treatment of complications of uveitis in 42 eyes and/or intravitreal application of anti-infectious or cytostatic drugs in 49 eyes. Overall, the visual acuity improved in 45% of eyes, remained unchanged in 45% of eyes, and decreased in 10% of eyes in 3 months after surgery.

Conclusions

Pars plana vitrectomy with carefully selected testing is a valuable tool for assessment of diagnosis in a large proportion of patients with uveitis. Moreover, the therapeutic effect of vitrectomy can improve the visual outcomes in these patients.
Pilot Study of Safety and Effect of Combined Intravitreal Bevacizumab and Methotrexate for Neovascular Age-Related Macular Degeneration
Authors: Soheilian Masoud , Movaseghi Mehryar , Ramezani Alireza , Peyman Gholam A.
Published: November 2010

Purpose

To evaluate the safety and effect of combined intravitreal methotrexate and bevacizumab on choroidal neovascularization in age-related macular degeneration (AMD).

Methods

Seven eyes of 7 patients (4 female; mean age 65.43±5.96 years) with choroidal neovascularization secondary to AMD were studied. Patients received intravitreal injection of methotrexate and bevacizumab and were examined every 1.5 months. Reinjections were performed with bevacizumab only.

Results

Three patients had 3 months, 3 had 4.5 months, and 1 had 8 months of follow-up. Mean number of reinjections was 2.0. In all patients, best-corrected visual acuity (BCVA) improved compared to baseline. Central macular thickness (CMT) decreased in all but one patient who had no reduced visual acuity. Mean BCVA (logMAR) was 1.27±0.43 D at baseline, 1.1 ±0.38 D at week 6, and 0.93±0.31 D at month 3. Mean BCVA in 3 patients at 4.5 months was 1.1±0.15 D. There were statistically significant differences between BCVA before injection and at week 6 (p=0.017), 3 months (p=0.005), and 4.5 months (p=0.04). Mean baseline CMT was 389±177 μm, 371±154 μm at 6 weeks, and 317±108 μm at 3 months. Mean CMT in 3 patients at 4.5 months was 266±66 μm. There were no statistically significant differences between baseline CMT and after treatment. No scar formation, increase of scar, or adverse reaction to methotrexate injection were seen.

Conclusions

Addition of intravitreal methotrexate to bevacizumab was safe in 7 eyes of 7 patients. It may enhance the therapeutic effect in regression of neovascularization in AMD and may reduce development of a fibrous component and disciform scar formation.
3D Characterization of the Influence of Porosity on Fatigue Properties of a Cast Al Alloy
Authors: Caty Olivier , Buffiere Jean‐Yves , Maire Eric , Adrien Jerome
Published: November 2010

Three‐dimensional (3D) images of casting defects present in broken and nonbroken fatigue samples of a cast Al alloy (A380–ISO: AlSi8Cu3Fe) have been obtained using laboratory X‐ray tomography. The 3D images have been processed to obtain various parameters (size, distance from the surface, projected area, etc.), for all the defects present in the gage length. 3D finite element meshes have also been generated from the tomographic images in order to compute the stress field at the vicinity of each defect. Correlations between the fatigue properties of the investigated samples and the above mentioned parameters are analyzed in order to elucidate which one seem to be predominant for the studied material.
Metal Nanocrystals with Highly Branched Morphologies
Authors: Lim Byungkwon , Xia Younan
Published: November 2010

Metal nanocrystals with highly branched morphologies are an exciting new class of nanomaterials owing to their unique structures, physicochemical properties, and great potential as catalysts, sensing materials, and building blocks for nanoscale devices. Various strategies have recently been developed for the solution‐phase synthesis of metal nanocrystals with branched morphologies, such as multipods and nanodendrites. In this Minireview, the procedures and mechanisms underlying the formation of branched metal nanocrystals are presented in parallel with recent advances in synthetic approaches based on kinetically controlled overgrowth, aggregation‐based growth, heterogeneous seeded growth, selective etching, and template‐directed methods, as well as their properties for catalytic or electrocatalytic applications.
Detection of Aβ Plaques by a Novel Specific MRI Probe Precursor CR‐BSA‐(Gd‐DTPA)n in APP/PS1 Transgenic Mice
Authors: Li Shuping , He Huijin , Cui Weigang , Gu Bing , Li Jin , Qi Zengxin , Zhou Guomin , Liang Chun‐min , Feng Xiao‐yuan
Published: November 2010

Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The lack of specific probes that can detect individual senile plaques in AD has prompted the development of magnetic resonance imaging (MRI) probes. In this study, based on DTPA‐gadolinium (III) and congo red (CR), a novel specific MRI probe precursor CR‐BSA‐(Gd‐DTPA)n was successfully synthesized. Its ability to bind to amyloid plaques was evaluated by brain sections from APP/PS1 transgenic mice. Its specificity for Aβ plaques was further demonstrated by immunohistochemistry (IHC) staining with the monoclonal antibody to the Aβ protein. Meanwhile, the amyloid deposits detected by the CR‐BSA‐(Gd‐DTPA)n were matched to the amyloid deposits detected by Aβ specific antibody. We also found that a few amyloid‐like deposits which was not detected by IHC. The findings indicated that the probe perhaps could detect the neurofibrillary tangles (NFT) similar to the effect of CR itself, and this will be verified in future experiments. The works suggested that the Aβ protein‐specific magnetic resonance contrast agent precursor CR‐BSA‐(Gd‐DTPA)n can be used as a potential fluorescence and MR multi‐modal imaging probe precursor to display individual senile plaques in AD. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Microsurgical Anatomy of Lumbosacral Nerve Rootlets for Highly Selective Rhizotomy in Chronic Spinal Cord Injury
Authors: Zhou Mou‐Wang , Wang Wen‐Ting , Huang Hong‐Shi , Zhu Gen‐Ying , Chen Ya‐Ping , Zhou Chang‐Man
Published: November 2010

It is known that selective sacral roots rhizotomy is effective for relieving the neurogenic bladder associated with spinal cord injury. The goal of this study is to review the surgical anatomy of the lumbosacral nerve rootlets and to provide some morphological bases for highly selective sacral roots rhizotomy. Spinal cord dissections were performed on five cadavers under surgical microscope. At each spinal cord segment, we recorded the number, diameter and length of the rootlets, subbundles and bundles from the L1 to S2 spinal segments, and the length of the dorsal/ventral root entry zone. Peripheral nervous system myelin was examined by immunohistochemistry. We found: (1) the ventral or the dorsal root of the lumbosacral segment of the spinal cord was divided into one to three nerve bundles and each bundle was subdivided into one to three subbundles. Each subbundle further gave out two to three rootlets connected with the spinal cord; (2) there were no significant differences in the number of rootlets within the L1 to S2 segments, but the size of rootlets and the length of nerve roots varied (P < 0.05); and (3) the more myelinated fibers a rootlet contained, the larger transection area it had. The area of peripheral nervous system myelin positive cells and the total area of rootlets were correlated (P < 0.001). Thus, during highly selective sacral roots rhizotomy, the ventral and dorsal roots can be divided into several bundles of rootlets, and we could initially distinct the rootlets by their diameters. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Angiogenesis of the Frozen‐Thawed Human Fetal Ovarian Tissue at the Early Stage after Xenotransplantation and the Positive Effect of Salviae miltiorrhizae
Authors: Wu Dandan , Lei Yaning , Tong Yuehong , Tang Fei , Qian Yunying , Zhou Ying
Published: November 2010

Cryopreserving ovarian tissue followed by transplantation has been suggested to preserve fertility for young cancer survivors. However, ischemia in the early stage after transplantation causes massive follicle loss. The aim was to investigate the histological and ultrastructural characteristics of the frozen‐thawed human fetal ovarian tissue after xenotransplantation and the effects of Salviae miltiorrhizae (SM) on the angiogenesis. The human fetal ovarian tissues were frozen‐thawed, xenografted into the immunodeficient nu/nu mice, and then collected 2, 7, and 28 days after transplantation. SM was administered. Compared with that of the frozen‐thawed ovarian tissue, the total follicle number of the grafts was greatly reduced. Nearly half of the primordial follicles were damaged at different levels on day 2. Moreover, edema was prevalent in the stroma during the first week after the graft, especially on day 2. The microvessel density of the grafts was increased on day 2, reached a peak on day 7, and then declined on day 28. Both healthy primordial follicle proportion and the total healthy primordial follicles pool in the SM group were significantly higher than those of the control group (P = 0.003 and P = 0.001). We found a statistically significant difference of microvessel density between the two groups on day 2 (P < 0.001). In the frozen‐thawed fetal ovarian grafts, angiogenesis has been begun on day 2, and the first week is the critical time for the grafts to regain their function, in which SM can facilitate graft vascularization and improve the preservation of primordial follicles. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Limit of hazard rate function of coherent system with discrete life
Authors: Mi Jie
Published: November 2010

In this paper we study the limiting behavior of the hazard rate function of a coherent system 𝒮 whose components are independent and have discrete lifetimes. The lifetime of the system 𝒮 can be viewed as the lifetime of a parallel system consisting of the series systems obtained from the minimal paths of 𝒮. If we appropriately interpret the ‘strongest’ minimal path(s) of the system 𝒮, it will be shown that the limit of the hazard rate functions of 𝒮 is the same as that of the ‘strongest’ path(s) of 𝒮. The application of the main results are also provided. Copyright © 2010 John Wiley & Sons, Ltd.
A Photoenzymatic System for Alcohol Oxidation
Authors: Gargiulo Serena , Arends Isabel W. C. E. , Hollmann Frank
Published: November 2010

A photocatalytic regeneration approach for the oxidized nicotinamide cofactors NAD(P)+ is presented. By simple irradiation with visible light, the rate of flavin‐mediated NAD(P)H oxidation is accelerated by two orders of magnitude. Catalytic use of the flavin is straightforward under aerobic conditions. Combined with alcohol dehydrogenases, photoenzymatic oxidation schemes are obtained allowing for selective, O2‐driven oxidation of primary and secondary alcohols. The simplicity and practical applicability of this oxidation approach is demonstrated in the oxidative lactonization of 1,4‐ and 1,5‐diols. Under nonoptimized conditions, total turnover numbers of 170 and 340 are achieved for the nicotinamide cofactor and the flavin catalyst, respectively.
T4 Virus‐Based Toolkit for the Direct Synthesis and 3D Organization of Metal Quantum Particles
Authors: Hou Li , Gao Faming , Li Na
Published: November 2010

One of the challenges in building superstructures based on small metal particles is producing stable interparticle separation. Herein, we present a novel assembly method based on the use of the T4 bacteriophage capsid as a scaffold for the construction of 3D monodisperse metal–particle arrays. The highly regular and symmetrical protein surface of the T4 capsid allows the site‐directed adsorption and subsequent reduction of metal ions, thus permitting the growth of metal particles in situ to enable them to exist at a quantum size with a high degree of monodispersity. Both these characteristics contribute to a great improvement in the electrocatalytic activity of the patterned noble‐metal particles. Organized magnetic particles as small as 2–4 nm still maintain an observable ferromagnetic behavior, which makes them promising for a variety of possible biomedical applications.
ChemInform Abstract: U and P4 Reaction Products: A Quantum Chemical and Matrix Isolation Spectroscopic Investigation.
Authors: Vlaisavljevich Bess , Gagliardi Laura , Wang Xuefeng , Liang Binyong , Andrews Lester , Infante Ivan
Published: November 2010

Reactions of laser‐ablated U atoms with P4 molecules in excess Ar or Ne during condensation at 5 K are monitored by FTIR spectroscopy.
ChemInform Abstract: EuxSr1‐xC2 (0 ≤ x ≤ 1): A Dicarbide Solid Solution with Perfect Vegard Behavior.
Authors: Link Pascal , Wandner Derk , Schellenberg Inga , Poettgen Rainer , Paulus Michael , Sahle Christoph J. , Sternemann Christian , Ruschewitz Uwe
Published: November 2010

The title compounds are prepared from the elements (Ta bomb, 1123 K, 24 h) and characterized by powder XRD and Moessbauer spectroscopy.
ChemInform Abstract: Crystal Structure of Ln3Ge1+xSe7 (Ln: La, Ce, Pr, Sm, Gd and Tb, x = 0.43—0.49) and Magnetic Properties of Ce3Ge1.47Se7.
Authors: Daszkiewicz M. , Strok O. M. , Gulay L. D. , Kaczorowski D.
Published: November 2010

La3Ge1.48Se7, Ce3Ge1.47Se7, Pr3Ge1.49Se7, Sm3Ge1.48Se7, Gd3Ge1.45Se7, and Tb3Ge1.43Se7 crystallize with the Dy3Ge1.25S7 type structure in the space group P63 with Z = 2 (single crystal XRD).
ChemInform Abstract: Crystal Structure of ErFe2D3.1 and ErFe2H3.1 at 450 K.
Authors: Sherstobitova E. A. , Gubkin A. , Stashkova L. A. , Mushnikov N. V. , Terent'ev P. B. , Cheptiakov D. , Teplykh A. E. , Park Junghwan , Pirogov A. N.
Published: November 2010

The structure of the title compounds is determined by X‐ray and high‐resolution neutron powder diffraction at 450 K.
ChemInform Abstract: Brillouin Spectroscopy, Calculated Elastic and Bond Properties of GaAsO4.
Authors: Cambon Olivier , et al. et al.
Published: November 2010

The elastic constants of hydrothermally grown single crystals of GaAsO4 are determined by Brillouin spectroscopy.
ChemInform Abstract: The Effects of Thermal Treatment on the Physical Properties of Sr2FeMo1‐xMxO6 Perovskite with M: W, Ta and (x ≤ 0.3).
Authors: Burzo E. , Balasz I. , Valeanu M. , Pop I. G.
Published: November 2010

The title compounds are prepared by solid state reaction of SrCO3, Fe2O3, MoO3, and WO3 or Ta2O5 (1300 °C for 4 h or 8 h).
ChemInform Abstract: In situ Observation of the Reaction of Scandium and Carbon by Neutron Diffraction.
Authors: Juarez‐Arellano Erick A. , Winkler Bjorn , Vogel Sven C. , Senyshyn Anatoliy , Kammler Daniel R. , Avalos‐Borja Miguel
Published: November 2010

The reaction of scandium and carbon is monitored by neutron diffraction up to 1823 K.
ChemInform Abstract: One‐Pot Synthesis of Uniform Carbon‐Coated MoO2 Nanospheres for High‐Rate Reversible Lithium Storage.
Authors: Wang Zhiyu , Chen Jun Song , Zhu Ting , Madhavi Srinivasan , Lou Xiong Wen
Published: November 2010

MoO2@C nanospheres with a size distribution of about 60—80 nm are hydrothermally synthesized from mixtures of (NH4)6Mo7O24, ethylene glycol, polyvinylpyrrolidone, and H2O (autoclave, 180 °C, 60 h) followed by thermal annealing at 700 °C for 4 h in a N2 flow.
ChemInform Abstract: Mechanochemical Synthesis of Nanocrystalline ZnWO4 at Room Temperature.
Authors: Mancheva M. , Iordanova R. , Dimitriev Y.
Published: November 2010

Nanocrystalline ZnWO4 powders are prepared by intense ball milling of stoichiometric mixtures of ZnO and WO3 at room temperature.
ChemInform Abstract: BaGa4Se7: A New Congruent‐Melting IR Nonlinear Optical Material.
Authors: Yao Jiyong , Mei Dajiang , Bai Lei , Lin Zheshuai , Yin Wenlong , Fu Peizhen , Wu Yicheng
Published: November 2010

The new title compound is synthesized by solid state reaction of BaSe and Ga2Se3 in the molar ratio 1:2 (900 °C, 72 h).
ChemInform Abstract: Synthesis of LaMO3 (M: Fe, Co, Ni) Using Nitrate or Nitrite Molten Salts.
Authors: Yang Jun , Li Runsheng , Zhou Junyi , Li Xiaoci , Zhang Yuanming , Long Yulin , Li Yongwang
Published: November 2010

Nanocrystals of the title compounds are prepared from mixtures of La(NO3)3 and Fe(NO3)3, Co(NO3)2, or Ni(NO3)2 in NaNO2, NaNO3—KNO3 eutectic, or NaNO3—KNO3 eutectic with Na2O2 molten salts (450—800 °C, 2 h).
ChemInform Abstract: BaNiSn3‐Type Ternary Germanides SrMGe3 (M: Ir, Pd and Pt).
Authors: Fujii H. , Sato A.
Published: November 2010

The compounds SrMGe3 (M: Rh, Ir, Ni, Pd, Pt) are prepared by arc‐melting of the elements followed by annealing at 1173 K for one week.
ChemInform Abstract: Hydrothermal Synthesis, Crystal Structure and Catalytic Properties of a Novel Polyoxometalate: (C5H7N2)3 (AsMo12O40) ·2C5H6N2·1.5H2O.
Authors: Cai Tie‐Jun , Shen Xiao‐Ming , Peng Zhen‐Shan , Lue Shu‐Zi , Deng Qian
Published: November 2010

The structure of title compound (III) is determined by single crystal XRD (monoclinic, space group P21/n, Z = 1).
ChemInform Abstract: Preparation and Characterization of Nanocrystalline Mg2FeH6.
Authors: Wang Yan , Cheng Fangyi , Li Chunsheng , Tao Zhanliang , Chen Jun
Published: November 2010

Nanocrystalline Mg2FeH6 is synthesized by ball milling of 3:1 mixtures of Mg and Fe powders under a hydrogen pressure of 5.5 bar at room temperature for 110 h.
ChemInform Abstract: Synthesis, Structure, and High Temperature Moessbauer and Raman Spectroscopy Studies of Ba1.6Sr1.4Fe2WO9 Double Perovskite.
Authors: Manoun B. , Benmokhtar S. , Bih L. , Azrour M. , Ezzahi A. , Ider A. , Azdouz M. , Annersten H. , Lazor P.
Published: November 2010

The title compound is synthesized by solid state reaction of a stoichiometric mixture of BaCO3, SrCO3, Fe2O3, and WO3 (1100 °C, 24 h in air).
ChemInform Abstract: Photoactivated Racemization Catalyst for Dynamic Kinetic Resolution of Secondary Alcohols.
Authors: Do Youngshil , Hwang In‐Chul , Kim Mahn‐Joo , Park Jaiwook
Published: November 2010

In the presence of fluorescent light and the Ru catalyst, secondary alcohols efficiently undergo racemization.
ChemInform Abstract: Enantioselective Synthesis of Highly Functionalized Amides by Copper‐Catalyzed Vinylogous Mukaiyama Aldol Reaction.
Authors: Frings Marcus , Goedert Daniel , Bolm Carsten
Published: November 2010

The title reaction affords amides with quaternary stereogenic centers in moderate to good yields and with up to 92% e.e.
ChemInform Abstract: Highly Enantioselective Michael Addition of Cyclic 1,3‐Dicarbonyl Compounds to β,γ‐Unsaturated α‐Keto Esters.
Authors: Chen Xing‐Kuan , Zheng Chang‐Wu , Zhao Sheng‐Li , Chai Zhuo , Yang Ying‐Quan , Zhao Gang , Cao Wei‐Guo
Published: November 2010

Title reaction proceeds with high enantioselectivities (up to 96% e.e.) in the presence of a novel amino acid‐derived thiourea—tertiary amine catalyst.
ChemInform Abstract: Nickel‐Catalyzed, Sodium Iodide‐Promoted Reductive Dimerization of Alkyl Halides, Alkyl Pseudohalides, and Allylic Acetates.
Authors: Prinsell Michael R. , Everson Daniel A. , Weix Daniel J.
Published: November 2010

The unprecedented title reaction proceeds with low catalyst loading (0.5 to 5 mol%), generally high yields (in average 80%) and good functional group tolerance.
ChemInform Abstract: Palladium(II)‐Catalyzed Highly Stereoselective Sandwich‐Type Triple Cyclization Reaction of 1,5‐Bisallenes and 2,3‐Allenoic Acids.
Authors: Lian Xiongdong , Ma Shengming
Published: November 2010

A sandwich‐type triple cyclization of two molecules of 2,3‐allenoic acid and one molecule of 1,5‐bisallene in the presence of a palladium catalyst with excellent stereoselectivity is developed.
ChemInform Abstract: Single Bifunctional Ruthenium Catalyst for One‐Pot Cyclization and Hydration Giving Functionalized Indoles and Benzofurans.
Authors: Nair Reji N. , Lee Paul J. , Reingold Arnold L. , Grotjahn Douglas B.
Published: November 2010

The cyclization of a range of aniline and phenol derivatives to indoles and benzofurans is presented.
ChemInform Abstract: Lewis Acid Promoted Reactions of Ethenetricarboxylates with Allenes: Synthesis of Indenes and γ‐Lactones via Conjugate Addition/Cyclization Reaction.
Authors: Yamazaki Shoko , Yamamoto Yuko , Fukushima Yugo , Takebayashi Masachika , Ukai Tetsuma , Mikata Yuji
Published: November 2010

Lewis acid promoted treatment of ethenetricarboxylates and the nitrile (Ie) with arylallenes allows new access to indenes.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Aminoarylation of Alkenes: C—C Bond Formation Through Bimolecular Reductive Elimination.
Authors: Brenzovich William E. Jr. , Benitez Diego , Lackner Aaron D. , Shunatona Hunter P. , Tkatchouk Ekaterina , Goddard William A. III , Toste F. Dean
Published: November 2010

In the presence of Selectfluor as oxidant and only 3 mol% of a bimetallic gold bromide terminal alkenesulfonamides undergo the title reaction with arylboronic acids in most cases at room temperature to give five‐ and six‐membered N‐heterocycles.
ChemInform Abstract: HOTf‐Catalyzed Rearrangement of Methylenecyclopropane Aryl and Alkyl Alcohols.
Authors: Tang Xiang‐Ying , Shi Min
Published: November 2010

A novel ring‐opening/ ring‐expansion rearrangement of methylenecyclopropane alcohols is presented.
ChemInform Abstract: First Example of Generation of Unsymmetrical Bis(imidoyl)ketene.
Authors: Lisovenko N. Yu. , Aliev Z. G. , Maslivets A. N.
Published: November 2010

Thermal decarbonylation of furandione (III) gives an unsymmetrical bis(imidoyl)ketene (IV) which undergoes an unusual intramolecular cyclization in situ furnishing benzophenazinol derivative (V).
ChemInform Abstract: Hypervalent λ3‐Bromane Strategy for Baeyer—Villiger Oxidation: Selective Transformation of Primary Aliphatic and Aromatic Aldehydes to Formates, Which Is Missing in the Classical Baeyer—Villiger Oxidation.
Authors: Ochiai Masahito , Yoshimura Akira , Miyamoto Kazunori , Hayashi Satoko , Nakanishi Waro
Published: November 2010

A modern strategy for Baeyer—Villiger oxidation is developed.
ChemInform Abstract: Supported Sulfonic Acid as Green and Efficient Catalyst for Baeyer—Villiger Oxidation with 30% Aqueous Hydrogen Peroxide.
Authors: Piscopo Calogero G. , Loebbecke Stefan , Maggi Raimondo , Sartori Giovanni
Published: November 2010

Baeyer—Villiger oxidation of a range of cyclic ketones with aqueous H2O2 solution proceeds efficiently in the presence of silica‐supported propanesulfonic acid to give the corresponding lactones in good selectivities.
ChemInform Abstract: Ionic Liquid Supported TEMPO as Catalyst in the Oxidation of Alcohols to Aldehydes and Ketones.
Authors: Fall Alioune , Sene Massene , Gaye Mohamed , Gomez Generosa , Fall Yagamare
Published: November 2010

ILT is designed and demonstrated to be an effective recyclable catalyst in the oxidation of primary and secondary alcohols.
ChemInform Abstract: KMnO4‐Mediated Oxidation as a Continuous Flow Process.
Authors: Sedelmeier Joerg , Ley Steven V. , Baxendale Ian R. , Baumann Marcus
Published: November 2010

An easy, rapid, and efficient method to prepare aldehydes, ketones, and carboxylic acids is reported.
ChemInform Abstract: Thiosemicarbazone Salicylaldiminato‐Palladium(II)‐Catalyzed Mizoroki—Heck Reactions.
Authors: Xie Guanlei , Chellan Prinessa , Mao Jincheng , Chibale Kelly , Smith Gregory S.
Published: November 2010

A novel catalyst is presented for the Mizoroki—Heck coupling reaction of a wide range of electron‐rich and electron‐deficient aryl halides with terminal olefins.
ChemInform Abstract: Phase‐Transfer‐Catalyzed Olefin Isomerization/α‐Alkylation of α‐Alkynylcrotonates as a Route for 1,4‐Enynes.
Authors: Hashimoto Takuya , Sakata Kazuki , Maruoka Keiji
Published: November 2010

The title olefin isomerization—α‐alkylation reaction provides access towards 1,4‐enynes deconjugated by an all‐carbon quaternary center.
ChemInform Abstract: Use of N‐Allylidene‐1,1‐diphenylethanamine as a Latent Acrolein Synthon in the Double Nucleophilic Addition Reaction of Ketene Silyl (Thio)acetals and Allylborolanes.
Authors: Shimizu Makoto , Kawanishi Mami , Mizota Isao , Hachiya Iwao
Published: November 2010

This allows efficient access to adducts of type (IV).
ChemInform Abstract: Broensted Acid Catalyzed Asymmetric Aldol Reaction: A Complementary Approach to Enamine Catalysis.
Authors: Pousse Guillaume , Le Cavelier Fabien , Humphreys Luke , Rouden Jacques , Blanchet Jerome
Published: November 2010

The phosphoric acid (R)‐POS is an efficient catalyst which allows formation of a number of β‐hydroxy ketones with moderate to good diastereo‐ and enantioselectivity.
ChemInform Abstract: Nitrophenylacetonitriles as Versatile Nucleophiles in Enantioselective Organocatalytic Conjugate Additions.
Authors: Cid M. Belen , Duce Sara , Morales Sara , Rodrigo Eduardo , Garcia Ruano Jose Luis
Published: November 2010

The title nitriles (I) and (VII) smoothly undergo Michael addition to α,β‐unsaturated aldehydes to afford the adducts in high yields, moderate diastereoselectivity, and good enantioselectivity.
ChemInform Abstract: Cobalt‐Mediated Linear 2:1 Cooligomerization of Alkynes with Enol Ethers to Give 1‐Alkoxy‐1,3,5‐trienes: A Missing Mode of Reactivity.
Authors: Leboeuf David , Iannazzo Laura , Geny Anais , Malacria Max , Vollhardt K. Peter C. , Aubert Corinne , Gandon Vincent
Published: November 2010

A variety of diynes and some borylalkynes undergo the title reaction with enol ethers (II), (IV) or (XIII) in the presence of cobalt complexes to furnish trienes with excellent levels of chemo‐, regio‐, and diastereoselectivity.
ChemInform Abstract: Electrophilic Trifluoromethylation of Arenes and N‐Heteroarenes Using Hypervalent Iodine Reagents.
Authors: Wiehn Matthias S. , Vinogradova Ekaterina V. , Togni Antonio
Published: November 2010

The potential of benziodoxole TFMHI as reagent for the direct trifluoromethylation of arenes and N‐heteroarenes is demonstrated and the role of different supporting additives such as zinc bromide or tris(trimethylsilyl)silyl chloride is discussed.
ChemInform Abstract: Long Chain Dicationic Phase Transfer Catalysts in the Condensation Reactions of Aromatic Aldehydes in Water under Ultrasonic Effect.
Authors: Esen Ilker , Yolacan Cigdem , Aydogan Feray
Published: November 2010

Long chain dicationic ammonium salts are successfully used as phase‐transfer catalysts in the condensation reactions of aromatic aldehydes in water under ultrasonic irradiation.
ChemInform Abstract: Ruthenium‐Catalyzed Tandem Enyne Metathesis/Hydrovinylation.
Authors: Gavenonis Jason , Arroyo Ruben V. , Snapper Marc L.
Published: November 2010

In situ modification of Grubbs′ first‐generation metathesis catalyst allows for a one‐pot tandem ruthenium‐catalyzed enyne metathesis/hydrovinylation sequence.
ChemInform Abstract: Copper‐Catalyzed Sequential Alkyl/Aryl or Vinyl Esterification of Dicarboxylic Acid Anhydrides with Alkoxysilanes.
Authors: Luo Fang , Pan Changduo , Qian Pengcheng , Cheng Jiang
Published: November 2010

It provides a new method for bis‐esterification and allows access to various dicarboxylic esters.
ChemInform Abstract: Saccharin Sulfonic Acid as an Efficient Catalyst for the Preparation and Deprotection of 1,1‐Diacetates.
Authors: Shirini F. , Mamaghani M. , Mostashari‐Rad T. , Abedini M.
Published: November 2010

Advantages of the title procedure are mild conditions, short reaction times, selectivity and easy work‐up.
ChemInform Abstract: Boron‐Based Dipolar Multicomponent Reactions: Simple Generation of Substituted Aziridines, Oxazolidines and Pyrrolidines.
Authors: Kielland Nicola , Catti Federica , Bello Davide , Isambert Nicolas , Soteras Ignacio , Luque F. Javier , Lavilla Rodolfo
Published: November 2010

New multicomponent reactions of aldehydes, isocyanides, trialkylboron reagents, and dipolarophiles open the route to the title compounds using solution and solid phase reactions under mild conditions.
ChemInform Abstract: Cobalt‐Catalyzed 1,4‐Hydrovinylation of Allylsilane and Allylboronic Esters for the Synthesis of Hydroxy‐Functionalized 1,4‐Dienes.
Authors: Arndt Marion , Reinhold Anne , Hilt Gerhard
Published: November 2010

The coupling of allylsilane and allylboronic esters with 1,3‐dienes allows access to 1,4‐dienes which react with aldehydes to afford hydroxy‐functionalized 1,4‐dienes.
ChemInform Abstract: Protecting‐Group‐Free Synthesis of Amines: Synthesis of Primary Amines from Aldehydes via Reductive Amination.
Authors: Dangerfield Emma M. , Plunkett Catherine H. , Win‐Mason Anna L. , Stocker Bridget L. , Timmer Mattie S. M.
Published: November 2010

The optimized conditions allow a new, efficient, and selective access to primary amines.
ChemInform Abstract: Organocatalytic Enantioselective Olefin Aminofluorination.
Authors: Appayee Chandrakumar , Brenner‐Moyer Stacey E.
Published: November 2010

Various alkyl substituents are tolerated in the multicomponent cascade reaction, whereas a cinnamaldehyde derivative is not converted.
ChemInform Abstract: Elemental Fluorine. Part 24. Fluorination of Ethers by Fluorine and Selectfluor
Authors: Chambers Richard D. , Okazoe Takashi , Sandford Graham , Thomas Emmanuelle , Trmcic Jelena
Published: November 2010

Reaction of dialkyl ethers with either fluorine or Selectfluor® leads to the formation of unusual difluorinated polyether products in modest yields.
ChemInform Abstract: Organocatalyzed Cyclopropanation of α‐Substituted α,β‐Unsaturated Aldehydes: Enantioselective Synthesis of Cyclopropanes Bearing a Chiral Quaternary Center.
Authors: Terrasson Vincent , van der Lee Arie , Marcia de Figueiredo Renata , Campagne Jean Marc
Published: November 2010

For the first time, a quaternary stereocenter in the α‐position of an aldehyde is created in an enantiocontrolled pathway (up to 97% e.e.) using a secondary‐amine organocatalyst.
ChemInform Abstract: Construction of a Quaternary Carbon at the Carbonyl Carbon of the Cyclohexane Ring.
Authors: Kaneko Yuki , Kiyotsuka Yohei , Acharya Hukum P. , Kobayashi Yuichi
Published: November 2010

A general protocol for the highly regio‐ and stereoselective allylic substitution of cyclohexylidene ethyl picolinates is presented.
ChemInform Abstract: A Cope Rearrangement Based Route to Hexahydroazulenes.
Authors: Seizert Curtis A. , Bumbu Valentina D. , Birman Vladimir B.
Published: November 2010

Various precursors for the rearrangement are readily available by short, high‐yield sequences.
ChemInform Abstract: Rhodium‐Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes Using Chiral Bicyclo[3.3.0] Diene Ligands.
Authors: Wang Zhi‐Qian , Feng Chen‐Guo , Zhang Shu‐Sheng , Xu Ming‐Hua , Lin Guo‐Qiang
Published: November 2010

The title reaction proceeds with high enantioselectivity to give a broad range of synthetically useful β,β‐disubstituted nitroalkanes.
ChemInform Abstract: Asymmetric Synthesis of Chiral Primary Amines by Transfer Hydrogenation of N‐(tert‐Butanesulfinyl)ketimines
Authors: Guijarro David , Pablo Oscar , Yus Miguel
Published: November 2010

as an efficient method to prepare α‐branched primary amines
ChemInform Abstract: Synthesis of N‐Nitrosoamines of the Adamantane Series.
Authors: Ovchinnikov K. A. , Moiseev I. K.
Published: November 2010

Adamantyl substituted N‐nitrosoamines (II) are described for the first time.
ChemInform Abstract: Chemoenzymatic Asymmetric Total Synthesis of (S)‐Rivastigmine Using ω‐Transaminases.
Authors: Fuchs Michael , Koszelewski Dominik , Tauber Katharina , Kroutil Wolfgang , Faber Kurt
Published: November 2010

A highly stereoselective synthesis of title compound (III) in four steps with an overall yield of 71% is presented.
ChemInform Abstract: Mild and Chemoselective Synthesis and Deprotection of Geminal Diacetates Catalyzed by Titanium(IV) Halides.
Authors: Jung Misuk , Yoon Jieun , Kim Hak Sung , Ryu Jae‐Sang
Published: November 2010

TiF4 and TiCl4 are efficient catalysts for the preparation of diacetates from either aldehydes or dimethyl acetals.
ChemInform Abstract: Perchloric Acid Catalyzed Homogeneous and Heterogeneous Addition of β‐Dicarbonyl Compounds to Alcohols and Alkenes and Investigation of the Mechanism.
Authors: Liu Pei Nian , Dang Li , Wang Qing Wei , Zhao Shu Lei , Xia Fei , Ren Yu Jie , Gong Xue Qing , Chen Jun Qin
Published: November 2010

It is found that HClO4 and silica gel supported HClO4 efficiently promote the addition of β‐dicarbonyl compounds to secondary alcohols and alkenes.
ChemInform Abstract: Acetic Acid Aldol Reactions in the Presence of Trimethylsilyl Trifluoromethanesulfonate.
Authors: Downey C. Wade , Johnson Miles W. , Lawrence Daniel H. , Fleisher Alan S. , Tracy Kathryn J.
Published: November 2010

The reactions of acetic acid and its silyl ester (IV) with non‐enolizable aldehydes allows a mild and direct access to β‐hydroxy acids in good to high yields.
ChemInform Abstract: New Heteroaromatic Azo Compounds Based on Pyridine, Isoxazole, and Benzothiazole for Efficient and Highly Selective Amidation and Mono‐N‐benzylation of Amines under Mitsunobu Conditions.
Authors: Iranpoor Nasser , Firouzabadi Habib , Khalili Dariush
Published: November 2010

Employing azopyridine in conjunction with triphenylphosphine in the reaction of carboxylic acids (I) with primary and secondary aliphatic and aromatic amines (II) affords the amides (III) by the Mitsunobu reaction.
ChemInform Abstract: Ultrasound‐Promoted Synthesis of Nitriles from Aldoximes under Ambient Conditions.
Authors: Jiang Nan , Ragauskas Arthur J.
Published: November 2010

Aldoxime substrates formed from aromatic aldehydes show a higher reactivity compared to aliphatic ones.
ChemInform Abstract: Palladium‐Catalyzed γ‐Arylation of α,β‐Unsaturated Esters from Silyl Ketene Acetals.
Authors: Huang David S. , Hartwig John F.
Published: November 2010

A method for the palladium‐catalyzed γ‐arylation of α,β‐unsaturated esters via silyl ketene acetals in the absence of fluoride is developed.
ChemInform Abstract: Stereoselective Cross‐Coupling of Baylis—Hillman Acetates with Diphenyl Disulfides and Diselenides Using Palladium Acetate.
Authors: Reddy P. Surendra , Reddy M. Amarnath , Sreedhar B. , Rao M. V. Basaveswara
Published: November 2010

A novel stereoselective synthesis of unsymmetrical sulfides and selenides from a variety of Baylis—Hillman acetates is described.
ChemInform Abstract: A General Palladium Catalyst System for Suzuki—Miyaura Coupling of Potassium Aryltrifluoroborates and Aryl Mesylates.
Authors: Chow Wing Kin , So Chau Ming , Lau Chak Po , Kwong Fuk Yee
Published: November 2010

Pd(OAc)2 in combination with IPP efficiently promotes the coupling of a number of aromatic mesylates with aryltrifluoroborates as well as vinyl‐ and alkyltrifluoroborates.
ChemInform Abstract: Palladium on Carbon‐Catalyzed Synthesis of Benzil Derivatives from 1,2‐Diarylalkynes with DMSO and Molecular Oxygen as Dual Oxidants.
Authors: Mori Shigeki , Takubo Masato , Yanase Takayoshi , Maegawa Tomohiro , Monguchi Yasunari , Sajiki Hironao
Published: November 2010

Oxidation of diarylalkynes (I) and (III) towards the corresponding benzil derivatives (II) and (IV), resp., proceeds smoothly in the presence of a dual oxidant system O2—DMSO and Pd—C catalyst.
ChemInform Abstract: An Investigation of the Catalytic Potential of Mono‐ and Dicationic Imidazolium N‐Heterocyclic Carbenes in the Benzoin Condensation.
Authors: Mavis Murat Emrah , Yolacan Cigdem , Aydogan Feray
Published: November 2010

Among the imidazolium compounds (I) and (II), derivative (Ia) is demonstrated to be the most efficient pre‐catalyst.
ChemInform Abstract: Regioselective Synthesis of Novel Spiroindan‐1,3‐diones Through 1,3‐Dipolar Cycloaddition Reactions.
Authors: Sarrafi Yaghoub , Hamzehlouian Mahshid , Alimohammadi Kamal , Khavasi Hamid Reza
Published: November 2010

Cycloaddition of an azomethine ylide, generated from ninhydrin and tetrahydroisoquinoline, with chalcones offers a novel diastereoselective synthesis of the target compounds.
ChemInform Abstract: Asymmetric Epoxidation of Substituted Chalcones and Chalcone Analogues Catalyzed by α‐D‐Glucose‐ and α‐D‐Mannose‐Based Crown Ethers.
Authors: Mako Attila , Rapi Zsolt , Keglevich Gyoergy , Szoelloesy Aron , Drahos Laszlo , Hegedues Laszlo , Bako Peter
Published: November 2010

The asymmetric epoxidation of substituted chalcones and chalcone analogues catalyzed by crown ethers leads to comparable and in a few cases, better results with respect to enantioselectivities, compared to those obtained in the presence of chinchona alkaloids.
ChemInform Abstract: Magnesium Iodide Promoted Defluorinative Reactions of 2,2‐Difluorocyclopropyl Aryl Ketones with Aryl Imines: A New, General Synthesis of 2‐Alkylideneazetidines.
Authors: Xu Wei , Ghiviriga Ion , Chen Qing‐Yun , Dolbier William R.
Published: November 2010

Upon treatment with anhydrous MgI2, 2,2‐difluorocyclopropyl aryl ketones undergo an unexpected and unprecedented ring opening process leading to complete loss of fluorine.
ChemInform Abstract: A Domino Reaction of α,β‐Acetylenic γ‐Hydroxy Nitriles with Arenecarboxylic Acids: An Unexpected Facile Shortcut to 4‐Cyano‐3(2H)‐furanones.
Authors: Trofimov Boris A. , Shemyakina Olesya A. , Mal'kina Anastasiya G. , Ushakov Igor A. , Kazheva Olga N. , Alexandrov Grigorii G. , Dyachenko Oleg A.
Published: November 2010

The addition of an arenecarboxylic acid to the alkyne triple bond is followed by intramolecular transesterification—enol formation.
ChemInform Abstract: A Flexible, Stereoselective Dimethylzinc‐Mediated Radical‐Anionic Cascade: Dramatic Influence of Additional Lewis Acids.
Authors: Maury Julien , Feray Laurence , Perfetti Patricia , Bertrand Michele P.
Published: November 2010

Treatment of fumarate with the iodides (II) and ZnEt2/air provides a new and stereoselective approach to trans‐2,3‐disubstituted γ‐lactones.
ChemInform Abstract: Iron and Copper Salts in the Synthesis of Benzo[b]furans.
Authors: Bonnamour Julien , Piedrafita Maria , Bolm Carsten
Published: November 2010

Intramolecular C—O bond forming reaction in o‐bromobenzyl aryl ketones is smoothly catalyzed by FeCl3 to give title benzofurans (II) and (IV).
ChemInform Abstract: New Approach to N‐Vinylpyrroles.
Authors: Tarasova O. A. , Nedolya N. A. , Albanov A. I. , Trofimov B. A.
Published: November 2010

The reaction of α‐lithiated allene (I) with isothiocyanate (II) offers an easy approach to the hitherto unknown pyrrole (IV) bearing several biologically and synthetically interesting functional groups.
ChemInform Abstract: Unusual Solid‐State Luminescent Push—Pull Indolones: A General One‐Pot Three‐Component Approach.
Authors: D'Souza Daniel M. , Muschelknautz Christian , Rominger Frank , Mueller Thomas J. J.
Published: November 2010

All products display an intense solid‐state fluorescence, yet they are completely nonemissive in solution.
ChemInform Abstract: First C—H Activation Route to Oxindoles Using Copper Catalysis.
Authors: Klein Johannes E. M. N. , Perry Alexis Perry , Pugh David S. , Taylor Richard J. K.
Published: November 2010

Atmospheric oxygen is required as reoxidant but an additional base is not necessary.
ChemInform Abstract: Asymmetric Addition of Indoles to Isatins Catalyzed by Bifunctional Modified Cinchona Alkaloid Catalysts.
Authors: Chauhan Pankaj , Chimni Swapandeep Singh
Published: November 2010

Several cinchona catalysts are tested in the first asymmetric organocatalytic Friedel—Crafts‐type addition of indoles to isatins.
ChemInform Abstract: Bromination of Indomethacin.
Authors: Ivachtchenko Alexandre V. , Yamanushkin Pavel M. , Mitkin Oleg D. , Kiselev Oleg I.
Published: November 2010

Indomethacin is brominated by NBS in AcOH in the aromatic positions C‐4 and C‐6, whereas the use of CCl4 allows access to derivative (V) brominated at the C‐2‐methyl group.
ChemInform Abstract: Branch‐Selective Synthesis of Oxindole and Indene Scaffolds: Transition Metal‐Controlled Intramolecular Aryl Amidation Leading to C3 Reverse‐Prenylated Oxindoles.
Authors: Ignatenko Vasily A. , Deligonul Nihal , Viswanathan Rajesh
Published: November 2010

In the presence of PdCl2(PPh3)2 amides of type (IV) undergo a novel cyclization to 2,2‐dimethyl indenes.
ChemInform Abstract: Enantioselective Oxidative Cross‐Coupling Reaction of 3‐Indolylmethyl C—H Bonds with 1,3‐Dicarbonyls Using a Chiral Lewis Acid‐Bonded Nucleophile to Control Stereochemistry.
Authors: Guo Chang , Song Jin , Luo Shi‐Wei , Gong Liu‐Zhu
Published: November 2010

In addition to the title reaction, a unique sp3 C—H‐activation‐based approach is presented which provides access to an oxindole derivative bearing a quaternary stereogenic center with high optical purity.
ChemInform Abstract: A Short and Efficient Synthesis of Furo[2,3‐b]indoles.
Authors: Kulkarni Mukund G. , Chavhan Sanjay W. , Desai Mayur P. , Shaikh Yunnus B. , Gaikwad Dnyaneshwar D. , Dhondge Attrimuni P. , Borhade Ajit S. , Ningdale Vijay B. , Birhade Deekshaputra R. , Dhatrak Nagorao R.
Published: November 2010

The approach to the title compounds (V) involves Wittig olefination, Claisen rearrangement, ozonolysis and subsequent reductive cyclization of the resulting unstable dialdehyde.
ChemInform Abstract: Synthesis of Naphtho[1,2‐d]imidazoles Containing an Adamantyl Fragment.
Authors: Gavrilova N. A. , Frolenko T. A. , Semichenko E. S. , Suboch G. A.
Published: November 2010

Novel naphtho[1,2‐d]imidazoles (III) are prepared starting from previously described adamantyl‐substituted naphthylene‐1,2‐diamines (I).
ChemInform Abstract: Facile Preparation of Oxazole‐4‐carboxylates and 4‐Ketones from Aldehydes Using 3‐Oxazoline‐4‐carboxylates as Intermediates.
Authors: Murai Kenichi , Takahara Yusuke , Matsushita Tomoyo , Komatsu Hideyuki , Fujioka Hiromichi
Published: November 2010

The intermediates are formed in a one‐pot condensation—oxidation directly from aldehydes.
ChemInform Abstract: Carbon Dioxide as the C1 Source for Direct C—H Functionalization of Aromatic Heterocycles.
Authors: Vechorkin Oleg , Hirt Nathalie , Hu Xile
Published: November 2010

The carboxylation is highly successful with Cs2CO3 as base in the absence of any catalyst.
ChemInform Abstract: Synthesis of Some Novel Benzobisthiazoles
Authors: Barrett Oscene V. , Downer‐Riley Nadale K. , Jackson Yvette A.
Published: November 2010

via reaction of o‐methoxythiobenzanilides with AIBN or basic ferricyanide
ChemInform Abstract: Enantioselective Wacker‐Type Cyclization of 2‐Alkenyl‐1,3‐diketones Promoted by Pd‐SPRIX Catalyst.
Authors: Takenaka Kazuhiro , Mohanta Suman C. , Patil Mahesh L. , Rao C. V. Laxman , Takizawa Shinobu , Suzuki Takeyuki , Sasai Hiroaki
Published: November 2010

The reaction proceeds in a 6‐endo‐trig mode with moderate to good enantioselectivities.
ChemInform Abstract: Intermolecular C—O Addition of Carboxylic Acids to Arynes.
Authors: Dubrovskiy Anton V. , Larock Richard C.
Published: November 2010

Biologically and pharmaceutically important structures are available under optimized conditions and various functionalities are tolerated.
ChemInform Abstract: Novel Coumarin Derivatives as Potential Antidyslipidemic Agents.
Authors: Sashidhara Koneni , Kumar Abdhesh , Kumar Manoj , Sonkar Ravi , Bhatia Gitika , Khanna A. K.
Published: November 2010

Among synthesized coumarins compound, (IIIb) is found to be the most active hypolipidemic agent in addition to having potent antioxidant activity.
ChemInform Abstract: An Efficient Approach to Functionalized Benzo[a]xanthones Through Reactions of 2‐Methyl‐3‐(1‐alkynyl)chromones with Electron‐Deficient Chromone‐Fused Dienes.
Authors: Gong Jian , Xie Fuchun , Chen Hong , Hu Youhong
Published: November 2010

The tandem reaction proceeds efficiently in the presence of DBU and microwave irradiation not requiring the use of metal catalysts.
ChemInform Abstract: New Fused Dithiabicyclic Compounds from the Reaction of N,N‐Dialkyl Perfluorothioamides with Allylmagnesium Halides.
Authors: Grellepois Fabienne , Timoshenko Vadim M. , Rusanov Eduard B. , Shermolovich Yuriy G. , Portella Charles
Published: November 2010

Allylmagnesium bromide reacts with perfluorothioamides to give, at low temperature, an adduct stable enough to be trapped.
ChemInform Abstract: 2,6‐Disubstituted and 2,2,6‐Trisubstituted Piperidines from Serine: Asymmetric Synthesis and Further Elaboration.
Authors: Acharya Hukum P. , Clive Derrick L. J.
Published: November 2010

A number of optically active target compounds can be prepared.
ChemInform Abstract: Efficient Synthesis of 2‐Fluoromethylated Quinolines via Copper‐Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides.
Authors: Li Shan , Yuan Yafen , Zhu Jiangtao , Xie Haibo , Chen Zixian , Wu Yongming
Published: November 2010

An efficient one‐pot synthesis of fluoroalkyl‐substituted quinolines is presented, involving the Cu‐catalyzed alkynylation of fluoroalkylimidoyl iodides (I) and (IV) and subsequent cyclization.
ChemInform Abstract: Synthesis of Highly Substituted Isoquinolone Derivatives by Nickel‐Catalyzed Annulation of 2‐Halobenzamides with Alkynes.
Authors: Liu Chuan‐Che , Parthasarathy Kanniyappan , Cheng Chien‐Hong
Published: November 2010

The methodology allows a total synthesis of the alkaloid oxyavicine (XVII) in 3 steps with excellent yield.
ChemInform Abstract: Nickel‐Catalyzed Denitrogenative Annulation Reactions of 1,2,3‐Benzotriazin‐4(3H)‐ones with 1,3‐Dienes and Alkenes.
Authors: Miura Tomoya , Morimoto Masao , Yamauchi Motoshi , Murakami Masahiro
Published: November 2010

The title reactions allow convenient and regioselective access to substituted 3,4‐dihydroisoquinolin‐1‐ones.
ChemInform Abstract: Effect of Oxygen Substituent in the Aniline Part of Benzanilide on the Regioselectivity in Direct Arylation Using Palladium‐Phosphine Reagents.
Authors: Harayama Takashi , Asai Mariko , Miyagoe Taeko , Abe Hitoshi , Takeuchi Yasuo , Yamaguchi Ayako , Fujii Shinya
Published: November 2010

The generality of the oxygen‐substituent effect on the coupling position is examined by the biaryl coupling reaction of benzanilides (I) and (IV), having oxygen substituents in the aniline part.
ChemInform Abstract: Synthesis of Fluoroazaindolines by an Uncommon Radical ipso Substitution of a Carbon—Fluorine Bond.
Authors: Laot Yann , Petit Laurent , Zard Samir Z.
Published: November 2010

Xanthates bearing various functionalities are added to the allyl group of pyridine (I).
ChemInform Abstract: Synthesis of 7‐[4‐Alkoxy‐3‐methoxy(hydroxy)phenyl]‐10,11‐dihydrobenzo [c]acridine‐8(7H,9H,12H)‐ones and 4‐(8‐Oxo‐7,8,9,10,11,12‐hexahydrobenzo [c]acridin‐7‐yl)‐2‐methoxy(ethoxy)phenyl Esters of Carboxylic Acids.
Authors: Kozlov N. G. , Basalaeva L. I. , Odnoburtsev B. A.
Published: November 2010

A Hofmann—Martius rearrangement mechanism is suggested for the reaction of known azomethines (I) with cyclohexane‐1,3‐dione.
ChemInform Abstract: [4 + 2] Cycloaddition Reactions Between 1,8‐Disubstituted Cyclooctatetraenes and Diazo Dienophiles: Stereoelectronic Effects, Anticancer Properties and Application to the Synthesis of 7,8‐Substituted Bicyclo[4.2.0]octa‐2,4‐dienes.
Authors: Grange Rebecca L. , Gallen Michael J. , Schill Heiko , Johns Jenny P. , Dong Lin , Parsons Peter G. , Reddell Paul W. , Gordon Victoria A. , Bernhardt Paul V. , Williams Craig M.
Published: November 2010

A detailed examination of the title reaction is presented employing triazoledione (II) or azodicarboxylate (IX) as diazo dienophiles.