bluuebunny/crossref_metadata_2025 huggingface dataset:
A variant in the CASR gene (c.368T>C) causing hypocalcemia refractory to standard medical therapy
Authors: Festas Silva Diana , De Sousa Lages Adriana , Caetano Joana Serra , Cardoso Rita , Dinis Isabel , Gomes Leonor , Paiva Isabel , Mirante Alice
Published: December 2021

Hypoparathyroidism is characterized by low or inappropriately normal parathormone production, hypocalcemia and hyperphosphatemia. Autosomal dominant hypocalcemia (ADH) type 1 is one of the genetic etiologies of hypoparathyroidism caused by heterozygous activating mutations in the calcium-sensing receptor (CASR) gene. Current treatments for ADH type 1 include supplementation with calcium and active vitamin D. We report a case of hypoparathyroidism in an adolescent affected by syncope without prodrome. The genetic testing revealed a variant in the CASR gene. Due to standard therapy ineffectiveness, the patient was treated with recombinant human parathyroid hormone (1–34), magnesium aspartate and calcitriol. He remained asymptomatic and without neurological sequelae until adulthood. Early diagnosis and treatment are important to achieve clinical stability.

Learning points

Autosomal dominant hypocalcemia (ADH) type 1 is one of the genetic etiologies of hypoparathyroidism caused by heterozygous activating mutations in the calcium-sensing receptor (CASR) gene.

The variant c.368T>C (p.Leu123Ser) in heterozygosity in the CASR gene is likely pathogenic and suggests the diagnosis of ADH type 1.

Teriparatide (recombinant human parathyroid hormone 1–34) may be a valid treatment option to achieve clinical stability for those individuals whose condition is poorly controlled by current standard therapy.
Pheochromocytoma due to a novel SDHD variant presenting as unilateral visual loss
Authors: Miller Clare , Pazderska Agnieszka , Reynolds John , Gou Patricia , Dunne Barbara , McElhinney Kealan , Owens Lisa
Published: December 2021

A 53-year-old female presented to a tertiary ophthalmology referral centre complaining of unilateral painless loss of vision. Subsequent assessment revealed malignant hypertension causing right-sided cystoid macular oedema. During the course of secondary hypertension workup, she was diagnosed with a 7.8 cm phaeochromocytoma which was resected. Testing for a panel of all predisposing phaeochromocytoma-causing variants using next-generation sequencing resulted in the diagnosis of a novel SDHD variant.

Learning points

Screening for secondary causes of hypertension is indicated when there is evidence of hypertension-mediated end-organ damage (1).

Testing for a predisposing variant should be considered in all patients with phaeochromocytoma or paraganglioma due to the high heritability rate and prevalence of somatic variants (2, 3, 4).

Novel variants are commonly uncovered in the Succinate Dehydrogenase (SDH) subunit; proving pathogenicity is a complex, time-consuming process and one challenge of next-generation sequencing (3).

SDHB immunohistochemistry as a tool for demonstrating pathogenicity is associated with reduced sensitivity when assessing SDHD variants (5, 6).
The glucagon receptor antagonist LY2409021 has no effect on postprandial glucose in type 2 diabetes
Authors: Hædersdal Sofie , Lund Asger , Maagensen Henrik , Nielsen-Hannerup Elisabeth , Gasbjerg Lærke S , Rosenkilde Mette M , Forman Julie L , van Hall Gerrit , Holst Jens J , Knop Filip K , Vilsbøll Tina
Published: December 2021

Objective

Type 2 diabetes (T2D) pathophysiology includes fasting and postprandial hyperglucagonemia, which has been linked to hyperglycemia via increased endogenous glucose production (EGP). We used a glucagon receptor antagonist (LY2409021) and stable isotope tracer infusions to investigate the consequences of hyperglucagonemia in T2D.

Design

A double-blinded, randomized, placebo-controlled crossover study was conducted.

Methods

Ten patients with T2D and ten matched non-diabetic controls underwent two liquid mixed meal tests preceded by single-dose administration of LY2409021 (100 mg) or placebo. Double-tracer technique was used to quantify EGP. Antagonist selectivity toward related incretin receptors was determined in vitro.

Results

Compared to placebo, LY2409021 lowered the fasting plasma glucose (FPG) from 9.1 to 7.1 mmol/L in patients and from 5.6 to 5.0 mmol/L in controls (both P < 0.001) by mechanisms involving reduction of EGP. Postprandial plasma glucose excursions (baseline-subtracted area under the curve) were unaffected by LY2409021 in patients and increased in controls compared to placebo. Glucagon concentrations more than doubled during glucagon receptor antagonism. The antagonist interfered with both glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide receptors, complicating the interpretation of the postprandial data.

Conclusions

LY2409021 lowered FPG concentrations but did not improve postprandial glucose tolerance after a meal in patients with T2D and controls. The metabolic consequences of postprandial hyperglucagonemia are difficult to evaluate using LY2409021 because of its antagonizing effects on the incretin receptors.
Bound lengths for type-I progressive hybrid burr type-XII censored data under SS-PALT
Authors: Prakash Gyan
Published: December 2021

Our main focus on combining two different approaches, Step-Stress Partially Accelerated Life Test and Type-I Progressive Hybrid censoring criteria in the present article. The fruitfulness of this combination has been investigated by bound lengths for unknown parameters of the Burr Type-XII distribution. Approximate confidence intervals, Bootstrap confidence intervals and One-Sample Bayes prediction bound lengths have been obtained under the above scenario. Particular cases of Type-I Progressive Hybrid censoring (Type-I and Progressive Type-II censoring) has also evaluated under SS-PALT. Optimal stress change time also measured by minimizing the asymptotic variance of ML Estimation. A simulation study based on Metropolis-Hastings algorithm have carried out along with a real data set example.
Seroprevalence of markers of transfusiontransmissible diseases in positive blood donors detected in routine screening in the Blood Bank of Hospital Carlos Luis Valverde Vega, Costa Rica. Period 2015 – 2019
Authors: Castro-Ruiz Jean Pablo
Published: December 2021

Blood is one of the fundamental tissues of our body. Blood donation allows blood banks to meet hospital needs for blood components. Blood transfusion is an activity that carries a risk, originated by a series of causal actions derived from the individual characteristics of donors and patients. Blood components are biological products and as such, they can never be exempt from the risk of transmitting infectious diseases, such as hepatitis B, HIV, syphilis, among others. Thanks to the investigation of the donor database of the Blood Bank of Hospital Dr. Carlos Luis Valverde Vega and the annual statistics of the blood bank, the statistics referring to donations were obtained, according to the type, grade of acceptance and as well as the prevalence of mandatory screening infectious diseases in the blood bank, between the years 2015 and 2019, with the respective authorization of the corresponding scientific ethics committee. This study reported a prevalence for Anti HB Core of 0.99%, 0.14% for HBsAg, 0.11% for syphilis, 0.05% for hepatitis C, 0.02% for HIV and 0% for the disease de Chagas and HTLV I / II. By using the bases of this work, future analyzes with a similar premise may be developed in different blood banks of the different health centers in our country.
Pulmonary pathology of COVID-19
Authors: Cheepsattayakorn Attapon , Cheepsattayakorn Ruangrong
Published: December 2021

Currently, animal-to-human transmission of SARS-CoV-2 (COVID-19) has not yet been confirmed, whereas the main mode of transmission is human-to-human. Droplets are the main route of human-to-human transmission, whereas aerosols could be another route in addition to stool-based transmission. Currently, no evidence is available to indicate intrauterine vertical transmission of SARS-CoV-2 (COVID-19) in pregnant women. In the host, the life cycle of coronavirus consists of 5 steps: 1) attachment, 2) penetration, 3) biosynthesis, 4) maturation, and 5) release. Once viruses bind to host receptors (attachment), they enter host cells, particularly type II pneumocytes via endocytosis or membrane fusion (penetration). Once viral contents are released inside the host cells, viral RNA enters the host’s nucleus for replication and making viral proteins (biosynthesis). New viral particles are produced (maturation) and released. Spike protein of coronaviruses which determines the diversity of coronaviruses and host tropism is composed of a transmembrane trimetric glycoprotein protruding from the viral surface. Structural and functional studies demonstrated that the spike protein the of coronaviruses can bind to angiotensin converting enzyme 2 (ACE2), a functional receptor for SARS-CoV. ACE2 expression is high in lung (high expression on lung epithelial cells), heart, ileum, and kidney. The lungs of severe COVID-19 patients demonstrate infiltration of a large number of inflammatory cells. Due to high ACE2 expression on the apical side of lung epithelial cells in the alveolar space, SARS-CoV-2 (COVID-19) can enter and destroy lung epithelial cells. Significant ACE2 expression on innate lymphoid cells (ILC)2, ILC3, and endothelial cells is also demonstrated. Pulmonary endothelial cells represent one third of the lung cells. Endothelial function includes promotion of anti-aggregation, fibrinolysis, and vasodilatation. Due to a significant role playing in thrombotic regulation, hypercoagulable profiles that are demonstrated in severe COVID-19 patients likely suggest significant endothelial injury. Pulmonary thrombosis and embolism accompanying elevation of d-dimer and fibrinogen levels have been demonstrated in severe COVID-19. In conclusion, whether these histopathological lesions are direct consequences of sepsis, SARS-CoV-2 (C)OVID-19), and /or multiple organ failure is difficult to conclude. Further studies on understanding the roles of ILC1, ILC2, ILC3, including the difference in response to SARS-CoV-2 (COVID-19) infection between children and adults are urgently needed to develop efficient targeted therapies.
Malignant pleural mesothelioma: Experience of the Medical Oncology Department of Hassan II Hospital in Fez, Morocco
Authors: Nouiakh Lamyae , Benbrahim Zineb , Oualla Karima , Haita Abdelkrim , Ouafki Imane , Berrad Soumia , Erraichi Hayat , Amaadour Lamiae , Arif Samia , Fatemi Hind El , Mellas Nawfel
Published: December 2021

Background: Malignant pleural mesothelioma (MPM) is a primary, rare and aggressive malignant tumor, closely correlated with asbestos exposure. Aim: The objective of this work is to study the main epidemiological, clinical, histological and therapeutic aspects of these tumors and to compare our results with those reported in the literature. Methods: We conducted a retrospective study of 8 cases of MPM collected at the medical oncology department of CHU Hassan II in Fez, for a period of 8 years from January 2011 to January 2019. Results: The mean age at diagnosis was 53 years with an F/H sex ratio of 1.7. Occupational exposure to asbestos was found in only one patient. Pleural effusion syndrome was present in all patients. Biopsy was done under thoracoscopy in 7patients (87.5%). MPM were mostly stage IV (50%). The standard treatment was conventional chemotherapy based on platinum, administered to all patients. After an average number of 4 courses, the objective response rate was 12.5%, and the disease control rate was 50%. Second line chemotherapy consisted of monotherapy with NAVELBINE (67%) or PEMETREXED (33%). After a median follow–up of 17 months, the median of progression–free survival was 5 months, and that of overall survival was 8 months. Conclusion: Based on the results of this study, we conclude that MPM is a very rare tumor in Morocco with poor prognosis. Prognostic factors affecting survival could not be studied due to the low number of patients included in the study, and the lack of data on medical records.
Demyelinating myelitis vs Acute ascending necrotizing myelitis
Authors: Luna Martìnez Jaime Adolfo , Guel, Elida Moran , Sandoval Rodríguez Nadia Viviana , Gonzalez Lucio Jorge Alberto
Published: December 2021

We present the case of a 26 year old male that was diagnosed with an acute ascending necrotizing myelitis, the initial symptoms were oppressive pain in the chest and numbness in both hands, followed by weakness of the arms and legs. The MRI detected a hyperintensity from C4 to T1. We suspected a demyelinating event, despite the prompt intervention the patient had progression of the disease, showing an aggressive disease. This case reveals a disease that mimics acute demyelinating diseases.
Prevalence of hearing impairment and outcome of universal neonatal hearing screening program in a tertiary care hospital – in UAE
Authors: ElHalik Mahmoud Saleh , Dash Swarup Kumar , Faquih Arif Moinuddin , Mahfouz Rim Aref , Shejee Faseela , Haroon Nazreen , ElAtawi Khaled Mahmoud
Published: December 2021

Background and objective: Hearing loss is one of the most common congenital anomalies, occurring in 1 to 3 per 1000 newborn infants in the well-baby nursery population, and 2 to 4 per 100 infants in the Neonatal intensive care unit graduates. The aim of the study is to identify babies with potential hearing loss and direct them to early intervention and rehabilitation. The program also initiated to create awareness about the need for detecting childhood deafness among parents and general population. An estimate of coverage, prevalence and proportion of babies defaulting newborn hearing screening program and diagnostic evaluation monitored closely to find the effectiveness of the program. Study design: This is a retrospective study and was conducted at Latifa women and children’s hospital (LWCH), a tertiary care referral hospital at Dubai, United Arab Emirates, over a period of two years from January 2018 to December 2019. Neonates admitted in Neonatal intensive care unit (NICU) and Post Natal wards (PNW) were screened. We followed three tier approach of hearing screening. All eligible neonates were subjected to Transient Evoked Oto-acoustic emission (TEOAE) prior to discharge. Automated auditory brainstem response (AABR) hearing screening was conducted in neonates who did not pass TEOAE test. Infant who failed second screening (AABR) were subjected to comprehensive hearing evaluation prior to three months of age. Results: Out of the total 7923 neonates, 7895(99.65%) were screened and 118 (1.49%) newborns referred for comprehensive audiological evaluation. Among them, 27(0.34%) were identified with various degrees of hearing loss. The prevalence of hearing loss was found to be 0.16% and 0.92% among neonates from PNW and NICU respectively. Conclusion: Implementation of Universal newborn hearing screening program is the need of the hour, as early detection of Hearing loss will aid early rehabilitation and better outcomes.
Evaluation of quality of life and functionality of patients chronic renal in hemodialysis treatment
Authors: Ferreira da Cruz Vitória Suyane , Santana Santos Glaucimária , Lima Yago Alves , Hora Almeida Lucas Aragão da , Oliveira de Matos Carlos José
Published: December 2021

Introduction: Chronic Renal Disease (CKD) is an insidious, asymptomatic, progressive and irreversible renal damage. Added to hemodialysis treatment triggers negative effects on the cardiorespiratory, musculoskeletal system and quality of life (QOL). Therefore, we sought to evaluate functionality, quality of life and respiratory muscle strength and peak expiratory flow in patients with chronic renal failure on hemodialysis. Materials and methods: A cross-sectional and descriptive study, with a convenience sample of 30 individuals. An individual identification form, the Kidney Disease and Quality-of-Life Short-Form (KDQOL- SF) quality of life assessment instrument and the Functional Independence Measure (FIM) instrument were used. Also, specific tests for evaluation of respiratory muscle strength (RMS) and peak expiratory flow (PEF). Results: A homogeneous sample characterized as old adults with low schooling, and mostly hypertensive and diabetic. Individuals with complete functional independence (FIM: 118.13±17.1). There was a great decline in respiratory muscle strength and peak expiratory flow, about 40-50% of predicted values. With significant impact on the situation of work and sexual function, 25±42.9 and 45.5±44.3, respectively. Positive values were obtained on social interaction and stimulation by the dialysis team. Conclusion: It was concluded that there are no impacts on its functionality. However, there is a significant decline in respiratory functional parameters, such as respiratory muscle strength and peak expiratory flow, as well as in the health-related quality of life of chronic renal patients undergoing hemodialysis treatment.
Long-term outcomes of thigh arteriovenous graft stenting
Authors: BS Masa Abaza , Almehmi Sloan E , AlBalas Alian , Almehmi Ammar
Published: December 2021

Background: Stents have been increasingly used for treating venous anastomosis stenosis seen in arteriovenous grafts (AVGs). A major reason for this trend is that stents can potentially confer a better patency rate compared to angioplasty. However, limited data are available about the outcomes of stents that are used to treat thigh AVG dysfunction. This study sought to assess the primary and secondary patency rates of stents used to treat thigh AVGs dysfunction at one year. Methods: This is a retrospective study of dialysis patients who received therapy via thigh grafts (N=50) and underwent stent placement between January 2005 and June 2017 at our center. Data on demographics and baseline characteristics of the study population were collected. The primary and secondary patency rates were defined as the time between stent deployment and the first intervention and second intervention, respectively. Patency and re-intervention rates were estimated using Kaplan-Meier survival analysis. Results: This study included 50 patients with thigh AVGs; mean age was 50.5± 15.5 years; 52% were female; 80% were black; and 90% had hypertension. The main indication for stenting was thrombosis due to venous anastomosis stenosis (74%). The number (mean ± SD) of stents deployed was 1.24 ± 0.8. The primary patency rate at three months and one year was 58.7% and 30.7%. In comparison, the secondary patency rate at three months and one year was 68.2% and 40.7% (p=0.04) Conclusions: Thigh AVG stenting can be successfully used to improve the overall patency rates of failing AVGs.
Sociabilidad femenina y archivo: lectura de tres álbumes de mujeres en el siglo XIX colombiano
Authors: Miseres Vanesa
Published: December 2021

Objetivo: el objetivo de este artículo es analizar los álbumes de amistad de tres mujeres del siglo xix en Colombia: Agripina Samper, Lastenia Soffía y María Gregoria de Haro. Metodología: el análisis se realiza a partir de las fuentes primarias señaladas, los álbumes, con una perspectiva de género y un acercamiento desde la historia cultural y social y los estudios de cultura material y sociabilidad femeninas. Originalidad: el artículo constituye un aporte para el conocimiento histórico del siglo xix colombiano. El análisis de los álbumes, que hasta el momento no han sido estudiados en profundidad, propone una nueva línea de estudio para entender las funciones que las mujeres desempeñaron en la vida social de la época. Conclusiones: los álbumes funcionan como soporte de las redes sociales de las mujeres y abren el panorama crítico al estudio de una serie de conocimientos e información sobre la cultura e historia local y global acerca de la educación, la literatura, la historia y los roles de género. En los álbumes se pueden escuchar las voces silenciadas por el archivo histórico hegemónico de las tres mujeres que les dieron forma y contenido y se comprueba la solidez e importancia de los vínculos entre las mujeres y su labor en medio de la escena política y cultural de una época.
El tiempo como significante abolicionista: un ingenio azucarero cubano según Anselmo Suárez y Romero
Authors: Ocasio Rafael
Published: December 2021

Objetivo: en este artículo documento la función laboral de los trabajadores esclavizados que llegaron a Cuba y fueron destinados mayormente a plantaciones azucareras durante la trata ilegal a partir de 1820. Analizo particularmente su presencia literaria en el costumbrismo, tendencia literaria del momento que autocensuró reportar las violaciones de los estatutos laborales que proveían para la manutención de los trabajadores esclavizados. Metodología: examino cuadros de costumbres representativos por Anselmo Suárez y Romero (1818-1878), recogidos en su Colección de artículos (1859). Originalidad: destaco ciertos cuadros de costumbres por Suárez y Romero, que clasifico bajo la categoría “laboral sentimentalista”, ya que revelan información detallada sobre las labores exhaustivas de los trabajadores esclavizados y abundantes datos personales presentados de manera positiva o como argumento, mediante una óptica antiesclavista. Conclusiones: analizo el paso del tiempo, marcado por frecuentes referencias a los atardeceres y a las noches de intenso trabajo físico para los trabajadores esclavizados, como una técnica literaria subversiva indirectamente relacionada al fuerte tono antiesclavista de estos cuadros de costumbres. Las imágenes de los crepúsculos y anocheceres son mayormente tétricas, relacionadas a la constante presencia de la muerte, una metáfora altamente romántica que apunta directamente al alto índice de muertes entre los trabajadores esclavizados.
Location of overhead power lines within Bukowe hills mesoregion in relation to the assessment of forest area fragmentation
Authors: Pieńkowski Paweł , Stoltman Marcin , Zakrzewski Bogusław
Published: December 2021

National power grid in Poland requires modernisation, therefore by 2030 numerous actions are scheduled regarding the expansion of the existing network and the construction of new electricity transmission lines (power lines). The planned activities will undoubtedly change the quality of landscape and result in fragmentation of forest habitats, some of which are characterised by high biodiversity and constitute a key element of ecological corridors. The aim of the present paper was to outline the issue of the impact of the power line corridors on forest habitat fragmentation, as well as to present the GuidosToolbox software (Graphical User Interface for the Description of image Objects and their Shapes) used, among other things, for the determination of the degree of fragmentation of forest habitats. The analysis concerned the Puszcza Bukowa forest, which is a part of the Natura 2000 network and is protected under the Szczecin Landscape Park ‘Puszcza Bukowa’. Despite abundant natural assets of the Puszcza Bukowa forest, it was necessary to run many power lines through its area due to location of the forest in the vicinity of the Szczecin agglomeration. The course of power lines contributed to the fragmentation of the discussed forest complex and to the depletion of its interior classified with the GuidosToolbox software as ‘Intact’. The software discussed in the present paper may prove useful in the identification of the degree of forest area fragmentation, connected with the course of high-voltage power transmission lines, and in the assessment of the impact of the planned investment projects on biocenoses.
Vocalizations and song flight of Pink-billed Lark Spizocorys conirostris
Authors: Engelbrecht Derek
Published: December 2021

Pink-billed Lark Spizocorys conirostris is an unobtrusive bird with a relatively low reporting rate of ~10% in the second South African Bird Atlas Project (SABAP2). Little is known about the species’ vocalizations and song flight, and published descriptions are vague or confus-ing. Here I provide a detailed description of vocalizations and song flights as recorded between 2012 and 2019 in Limpopo Province, South Africa. Vocalizations were recorded using a digital recorder for calls in flight and occasionally on the ground, or were obtained from a video camera placed near the nest to record vocalizations that would be impossible to record from a distance. Twelve categories of vocalizations were identified, eight of them described here for the first time. The majority of the eight newly described vocalizations were obtained from video footage. A more detailed description of the song flight is also provided and should clarify some of the confusing descriptions provided in the literature. Knowledge of the flight song of Pink-billed Lark is valuable to locate and identify the species and will be an asset for moni-toring programmes and SABAP2.
Quarantine Understanding of Some Metaphysical Problems
Authors: Leontieva Elena , Leontiev Alexander
Published: December 2021

The pandemic and the quarantine situation have had and continue to have multi-directional influence on the processes of social and individual life. From unprecedented acceleration and progress (in information technologies and getting involved with them) to slowdown, and sometimes full stop and stagnation (tourism business, transport sector). Comprehension of what is happening will be a long process. The authors propose to revaluate some metaphysical problems actualized by the experienced situation. These issues include virtual reality, which clearly defined its boundaries and it became clear that the state many plunged into in the process of quarantine and isolation is not a kind of it. The problem of social space, which has changed, intertwined, confused a person in his social roles and statuses. Physically, one place of stay at different times of the day with the help of information technologies was transformed into a space for work, scientific debate, education, family life, entertainment and even sports. The philosophical problem of uncertainty having left the theoretical discourse has directly invaded the lifeworld and everyday life of every person, influenced all spheres of life, plans and prospects for the future. Becoming a social reality uncertainty during a pandemic has acted as a factor that erodes the existence of people, their habitual, definable, measurable being, which begins to lose its characteristics, losing its identity. It becomes unpredictable, ambiguous, unplanned. Such a being casts doubt on many usual forms of organizing the achievement of results in almost any field of activity: setting a goal, choosing methods and systematic movement towards its implementation. That is how project thinking is realized. However, in a situation of total uncertainty, it begins to fail and turns out to be inefficient. A possible overcoming this situation is thinking aimed at realizing and «understanding real circumstances». Thinking that was appreciated primarily by Russian philosophers and the Eastern tradition of philosophy.
The Crisis of Recognition in the Context of Social Exclusion
Authors: Kopaneva Valeriya
Published: December 2021

The author suggests the idea of reflecting the experience of social exclusion and considers the problem faced by people, communities and social institutions, that is a crisis of recognition. Recognition is referred to as the process during which one subject formulates new knowledge about another and evaluates it, as a result of it a commonality arises between them. However, in the conditions of the new reality, the negative consequences of isolation are visible, which are expressed in the following forms: spatial disunity, alienation, lack of communication, lack of joint social practices, separation from the community, individualization and, as a result, non-recognition. The idea of isolation prevents recognition. Isolation implies isolation / autonomy from social contacts, difficulty in gaining new knowledge about other objects, which leads to a weakening of the mimetic aspect of recognition and an increase in the perception of the danger of the Other. At the same time, the idea of initiation, which involves crossing the border, is an integral part of recognition – this fact implies the presence of at least two spaces of different quality, that is why, it is necessary to observe the principle of horizontality. Spaces are not arranged hierarchically, in online practices there is no boundary between private and public spaces, respectively, if there is no priority of one space over another, then there is no need to give recognition. The lack of recognition leads the subject to disorientation: when it becomes difficult for him to evaluate and understand the processes occurring not only with him, but also in the external world. Thus, we conclude that online practitioners do not form communities and shared presence that prevents the expression of recognition.
Features of the Perception of a Life Perspective in a Difficult Life Situation (On the Example of the COVID-19 Pandemic)
Authors: Timofeeva Tatiana , Belikova Alina
Published: December 2021

The article presents the results of an empirical study of the relationship between life time perspective and the peculiarities of cognitive assessment and emotional perception of the COVID-19 pandemic as a difficult life situation. The paper presents a theoretical review of current domestic and foreign studies of theories of life and time perspective within the psychological time of the individual. The life perspective is considered as a complex of conditions and circumstances that provide a person with the opportunity to develop on his life path. The time perspective is seen as a motivational aspect of life. In the work, to collect data, the survey method (questionnaire) was used, as well as Method for the diagnosis of cognitive assessment of difficult life situations by E.V. Bityutskaya; Questionnaire of Zimbardo's time perspective. The data were processed by methods of mathematical statistics (contingency tables, frequency, correlation analysis). The results of the psychological research showed that respondents with a pronounced perspective of orientation towards a positive past most often experience difficulties in making decisions in the present. Moreover, if a person is focused on the present, then most often it is accompanied by negative emotional states - apathy, despair, grief, anxiety. It was also found that respondents with a pronounced future orientation perspective do not experience strong negative emotions. Nevertheless, for the overwhelming majority of respondents, the future seems distant and vague, due to which they are unable to make plans and view their lives in the future. Many people are afraid to make plans in a pandemic situation, avoid responsibility, make impulsive decisions, seek pleasure, which increases the risks of social maladjustment.
Professional Age: On the Issue of Sociological Conceptualization (On the Example of Professional Athletes)
Authors: Yermilova Anna
Published: December 2021

The article presents a sociological conceptualization of the category "professional age" in relation to the field of professional sports. Based on the interpretation of the terms "age" and "professional athlete", the author's vision of the category "professional age" is proposed. The interpretation of the concept of "professional age" is carried out through the prism of chronological, biological, social, and psychological ages, as a result of which the specifics of professional age are determined on the example of professional athletes. The specific features of integration of athletes into the professional environment, which is associated with the specific functioning of this sphere of activity that affects the process of formation of their professional age, are shown. In turn, the professional age of athletes is determined, firstly, by the earlier entry of the individual into the professional sports environment and, consequently, by a faster entry into professional age; secondly, a shorter work experience depending on the sport compared to other areas of work and, accordingly, a faster completion of professional age. Factors leading to the formation of perceptions of professional age are established: discrepancy between the chronological and social functioning of the individual; effects of biological ageing on the course of professional age; effect of psychological aging on the duration of professional age. The characteristics of the professional age of athletes that have a changeable nature of existence are revealed: heterochronicity, variability, normativity, multidimensionality, linearity and cyclicality. The professional age of athletes is analyzed as a multivariate social phenomenon, in particular, the significance of biographical, ideological, social-stratificational, ethnological, historical, aesthetic research aspects is revealed. The socio-cultural features of the professional age of the representatives of elite sport are for egrounded, firstly, the construction of the sports self-awareness of the individual / community, which is specific depending on the kind of sport; secondly, the construction of a sports subculture based on a constant stressful situation. On the basis of theoretical developments, the author's conceptualization of the professional age of athletes is proposed.
Social Consequences of the Pandemic in the Context of Modern Education Problems
Authors: Matvienko Evgeniy
Published: December 2021

The article is dedicated to the analysis of the main trends of evolution of the educational sphere of society and the impact of the COVID-19 pandemic on it. There are four basic trends in the development of education. The first is the audiovisual turn in modern culture accompanied by a crisis of "book culture". New learning technologies, making the material extremely accessible, do not developing the basic cognitive abilities of the individual. The "will to know" is not formed», as well as the desire and willingness to overcome the inevitable difficulties that arise in its course. The next factor is the total commercialization and consumerization of educational activities. Education is increasingly understood not as a selfless transfer of the accumulated experience of civilization, but as the provision of paid services. This gives its consumer additional rights and it creates unreasonable expectations. The third circumstance is devaluation of the classical interpretation of education as a unity of teaching and upbringing. There was a clear bias towards the first one. Education, understood as the process of forming a harmonious personality, it was in the background. The final trend in the development of education is the spreading of postmodern theories and related practices into it («postmodernization»). The pandemic is proving to be the most important factor in accelerating it. Due to the distance learning format the educational space is fragmented, atomized – both physically and intellectually. Its universal principles, goals, and content are being eroded. The social experiment launched by the pandemic proved that mostly distance education is technically possible, economically profitable, increases the emphasis on the pragmatic component of education to the detriment of the axiological one and contributes to the progressive postmodernization of education. In conclusion, it is pointed out that Western philosophy in the works of its most prominent representatives repeatedly played with the metaphor of death of God (Nietzsche), subject (Foucault), author (Barthes). By analogy, the thesis is put forward (accelerated witch pandemic) about «the death of a Teacher», manifested primarily in loss by the pedagogical community and society as a whole a view of the importance of the Teacher's social mission.
Exact Solutions of the Generalized Nonlinear Schrodinger Equation
Authors: Shaikhova Gaukhar , Syzdykova Arailym , Daulet Samgar
Published: December 2021

In this work, the generalized nonlinear Schrodinger equation is investigated. Exact solutions are derived by the sinecosine method. This method is used to obtain the exact solutions for different types of nonlinear partial differential equations. Graphs of obtained solutions are presented. The obtained solutions are found to be important for the explanation of some practical physical problems.
On the Use of the Wilcoxon Criterion in the Practice of Pedagogical Research
Authors: Bondareva Elena , Mazepa Elena
Published: December 2021

The article discusses the use of nonparametric measures of influence in pedagogical research. The Wilcoxon criterion for comparing indicators obtained as a result of measurements in a connected sample is highlighted. The necessary conditions for the application of the criterion, as well as the advantages of its use are indicated. The possibility of using the Wilcoxon criterion is illustrated by the example of determining the effectiveness of the proposed teaching methodology using the Uchi.ru online platform in educational activities. Most modern studies in the field of pedagogy and psychology, along with qualitative descriptions of the results of the research, actively use quantitative analysis. Last analysis includes processing of the data using methods of mathematical statistics. In order to show the effectiveness of the developed methodology for the learning process, it should be considered as a factor influencing changes in the studied trait. Further study of these changes allows the researcher to determine the statistical reliability (significance) of the influence of the factor under consideration. The subsequent analysis of the reliability of the influence of a particular factor, the comparison of the measure of influence of various factors is carried out using parametric (variance analysis) and nonparametric measures of influence (the sign criterion, the Wilcoxon criterion). This article discusses the use of nonparametric measures of influence in pedagogical research. The Wilcoxon criterion is selected for comparing the indicators obtained as a result of measurement in a connected sample and allowing to diagnose not only the direction of changes, but also their severity. The necessary conditions for the application of the criterion, as well as the advantages of its use, are indicated. The possibility of using the Wilcoxon criterion is illustrated by the example of determining the effectiveness of the proposed teaching methodology using the Uchi.ru online platform in educational activities. Conclusions are made about its inefficiency for mastering the material in mathematics for younger schoolchildren.
Modeling of Flooding of Settlements During the Spring Flood
Authors: Klikunova Anna , Dyakonova Tatyana , Agafonnikova Ekaterina , Makoveev Ilya , Kornaukhova Mariya , Radchenko Viktor
Published: December 2021

The problem of flooding of territories with flood waters for settlements of the Volgograd region is considered. A numerical model of flood water dynamics is constructed, taking into account the topography of the terrain. The simulation is based on two-dimensional shallow water equations. For computational experiments, a parallel implementation of the numerical scheme CSPH-TVD for NVIDIA graphics accelerators with CUDA technology is used. The digital model of the river-bed and floodplain relief is based on spatial data SRTM3 and SRTMGL, topographic maps of the area, longitudinal profiles of rivers. The water flow rates for the Buzuluk and Perevozinka rivers are determined and a hydrograph of the Volga hydroelectric power station is constructed for the given probabilities of exceeding the water level. Flood maps were obtained for the following localities: Novoannisky, Berezovka 1st, kh. Vyazovka. The maximum values of the depths for 1 %, 3 %, 5 %, 10 %, 25 % and 50 % of water security are presented. An analysis of the flood situation was carried out and appropriate engineering and protective measures for settlements were proposed. At maximum flood water levels, residential buildings of kh. Berezovka 1-I are not subject to flooding. In order to minimize the negative impact for the city of Novoanninsky, it is proposed to carry out timely clearing of the river-bed of the Perevozinka river from congestion. To protect from flooding ch. Vyazovka it is recommended to use diversion dyke.
Relationships between Cultural Adaptation and Immigrants’ Well-Being
Authors: Martinet Érica Henke Garcia , Damásio Bruno Figueiredo
Published: December 2021

Abstract The present study aimed to evaluate the predictive relationship of socio-demographic variables, cultural adaptation and hope on general well-being (GWB), subjective (SWB), social (SoWB) and psychological (PWB) and in the meaning of life. The participants consisted of 108 immigrants. The instruments used were: bio sociodemographic questionnaire, Mental Health Continuum - Short Form, Dispositional Hope Scale, Acculturation Measures and Meaning of Life Questionnaire. In general, only sociocultural adaptation showed a positive predictive relationship with all types of well-being studied, nonetheless this measure presented a negative predictive relationship regarding the presence of meaning in life. Psychological adaptation was predictively and positively related only to SWB. The perception of cultural distance negatively affected SoWB. The presence of meaning was also negatively predicted by the type of immigration and age. The search for meaning was negatively predicted only by income. The results are important for a better understanding of factors that influence the experience of immigrants in Brazil.
Growth stanza in fish life history using otoliths shape: the protandric Centropomus case (Carangaria: Centropomidae)
Authors: Medeiros Reginaldo , Oliveira Cicero D. , Souto Daniele , Rangely Jordana , Fabré Nídia N.
Published: December 2021

ABSTRACT Morphoanatomical or physiological changes coupled with changes in body size are known as allometric relationships. The objective of this study was to identify the points of growth changes in Centropomus based on otolith morphometry and morphogeometry. For this purpose, 455 individuals of C. undecimalis and 176 of C. parallelus were collected from artisanal fishermen of the coast of the state of Alagoas, Brazil. The sagittal otoliths were measured for length, height, perimeter, area and weighed. The potential and polyphasic models were fitted between total fish length and otolith length. The morphotypes otoliths wen describe by form Fourier descriptors and shape indices. The polyphasic model detected three growth phases. The first stanza for C. undecimalis was at 46.8 cm and the second at 75.9 cm. For C. parallelus, it was at 18.8 cm and at 41.2 cm. Each stanza has a specific otoliths morphotype in both species. The otoliths of C. undecimalis and C. parallelus exhibited ontogenetic allometric changes in their growth pattern with two stanzas changing points. The stanzas corresponded to specific lengths reached by individuals over their life cycles, such as their size at maturity and length at sexual reversion.
International Cooperation and Negotiated Settlements for Transnational Bribery: A Study of the Odebrecht Case
Authors: Pimenta Raquel de Mattos , Venturini Otavio
Published: December 2021

Abstract Transnational regulation of bribery involves several increasingly complex forms of cooperation among enforcement authorities. International investigative cooperation allows a foreign authority to assist another on criminal and/or civil investigations, through requests of mutual legal assistance, rogatory letters, as well as joint investigative teams. Sanction-based cooperation helps different authorities to transfer or extradite persons and recover proceeds of corruption to the victims. More recently, there has been a rise in cooperation in negotiated settlements with the accused. Settlement cooperation may entail joint resolutions or the coordination of settlement clauses. This paper focuses on how these three modes of cooperation intersect in cases with successive negotiated settlements. We use the Odebrecht case settlements to unpack the relation between investigative, sanction-based, and settlement cooperation in three case studies: the joint resolutions between the company and Brazil, Switzerland, and the United States, as well as two local agreements with the Dominican Republic and with Peru. We evidence how these modes of cooperation can reinforce or undermine one another. Beyond illustrating different cooperation dynamics, we also explore the role of sequencing. The existence of a previous joint resolution affects the developments of the subsequent agreements, but in different ways from those previously mapped by the literature.
A CULTURA PODE EVOLUIR ?
Authors: Abrantes Paulo C.
Published: December 2021

(Este artigo faz parte de um projeto da Trans/Form/Ação: revista de filosofia da Unesp. Trata-se do Dossiê Filosofia Autoral, a ser publicado em 2022.)

O artigo parte de uma distinção entre tipos de descrição que podem ser propostas para uma dinâmica populacional, incluindo uma descrição ‘darwiniana’ em termos de variação, herança e aptidão diferencial, envolvendo as entidades que compõem a população relevante. Em seguida, propõe-se uma categorização de tipos de populações culturais e investiga-se as condições mais gerais que precisam ser satisfeitas para que as dinâmicas dessas populações tenham um caráter evolutivo e darwiniano, em especial a população composta pelos próprios traços culturais. Destacamos algumas abordagens da evolução na linhagem hominínea, como a teoria da dupla herança e a memética, que concedem à evolução cultural um lugar privilegiado nos seus cenários. Essas abordagens contribuem, desse modo, para o desenvolvimento de uma teoria geral da evolução cultural, e as comparamos, nesse tocante, com outras abordagens, como a psicologia evolucionista. Esses confrontos também permitem ilustrar analogias entre a evolução biológica e a evolução cultural, bem como falhas na analogia.
Teratogenicidad de anestésicos
Authors:   Hospital General Iess Santo Domingo, Guamán Cobos Victor Hugo
Published: December 2021

El seguimiento adecuado del embarazo limita la aparición de estas enfermedades en la expresión del genotipo y fenotipo por tanto darle varias vistas como cultura general a este ejemplar desempolva conocimientos adquiridos a lo largo de la carrera medica La afectación del sistema urinario, osteomuscular, cardiaco, sistema nervioso y otras estructuras hace que su estudio sea minucioso para la detección temprana y tomar decisiones prudentes dentro de la gestación El estudio de estas presentaciones anómalas en el producto merecenun estudio tanto del paciente como de la madre para determinar las variables y sus resutados con la toma de decisiones.
REFLEXÕES SOBRE O NÃO DITO NA EDUCAÇÃO MUSICAL: UM ESPAÇO A SER OCUPADO PELA MÚSICA CONTEMPORÂNEA
Authors: Gomes Érica Dias
Published: December 2021

A educação musical formal no Brasil tem privilegiado o repertório do período de prática comum, em detrimento de composições de outros contextos. Este trabalho visa refletir sobre esta predominância, questionando a ausência específica da produção contemporânea no ensino formal. Foi realizada revisão teórica, abordando relações entre a história da educação musical brasileira e a consolidação deste tipo de repertório, além de alguns apontamentos sobre produções musicais contemporâneas e características da contemporaneidade. Desta forma, aponta-se para a importância da presença da música erudita contemporânea enquanto possibilidade de articular a necessidade de ampliação de repertório com o desenvolvimento da musicalidade em um aspecto mais amplo, a partir das relações entre as múltiplas tendências estéticas na construção musical.