bluuebunny/crossref_metadata_2025 huggingface dataset:
Caracterización de los efectos del COVID 19 en la competitividad, teletrabajo, cadenas de valor y comercio electrónico de la Alianza Pacifico durante el año 2020
Authors: Narváez Ferrín María Erika , Cruz Páez Fabio Orlando , Lechuga Cardozo Jorge Isaac , Avendaño Avendaño Marilú , Fabio Rodríguez Héctor
Published: November 2022

Esta propuesta de investigación permitirá identificar los efectos que ha tenido el COVID 19 en la competitividad, teletrabajo, cadenas de valor y comercio electrónico de la Alianza Pacifico durante el año 2020, donde los países miembros (Colombia, México, Perú, y Chile) instauraron en el Acuerdo Marco como objetivo principal establecer un área de integración profunda con el fin de continuar progresivamente en pro de una libre circulación de bienes, servicios, capitales y personas, motivando así desarrollo, crecimiento y competitividad. El alcance será a nivel internacional con los países miembros, bajo la metodología mixta analítica y diseño no experimental, pues se analizan las diferentes categorías de variable: comercio electrónico, competitividad, cadenas de valor y teletrabajo. El diseño de investigación planteado es transversal, ya que en el estudio no se asumirá seguimiento en el tiempo y se desarrollar en un periodo específico. Se realizará integración de las teorías económicas del diamante de Porter y el uso de la ventaja competitiva para construir la reflexión de los resultados obtenidos en la fase cualitativa y cuantitativa que faciliten localizar un modelo teórico que explique el fenómeno de la competitividad y el efecto del COVID19 en estas economías. Como resultados de la investigación, luego del análisis de los datos recolectados con los diferentes instrumentos que se aplicarán se obtendrán: Ponencias, artículos, trabajo de grado y el informe final donde se presenta el estudio actualizado que propenda a la toma de decisiones estratégicas en el modelo comercial entre los países miembro de la Alianza Pacífico.
CO 2 -induced chloroplast movement in one cell-layer moss leaves
Authors: Sugiyama Taichi , Terashima Ichiro
Published: November 2022

CO -induced chloroplast movement was reported in the
monograph by Gustav Senn in 1908: unilateral CO supply
to the one cell-layered moss leaves induced the positively CO
-tactic periclinal arrangement of chloroplasts.
However, from the modern criteria, several experimental settings are
unacceptable. Here, using a model moss plant Physcomitrium
patens, we examined basic features of chloroplast CO
-tactic relocation with a modernized experimental
system. The CO relocation was light-dependent and
especially the CO relocation in red light was
substantially dependent on photosynthetic activity. Between the
cytoskeletons responsible for chloroplast movement of P. patens,
the microfilament mainly worked for CO relocation, but
the microtubule-based movement was insensitive to CO .
The CO relocation was induced not only by air with and
without CO but also by the more realistic difference
in CO concentration between the two sides. In the
leaves placed on the surface of a gel sheet, chloroplasts avoided the
gel side and positioned in the air facing surface. This was also shown
to be photosynthesis dependent. Based on these observations, we propose
a working hypothesis that the threshold light intensity between the
light-accumulation and -avoidance responses of the photorelocation would
be increased by CO , resulting in the CO
-tactic relocation of chloroplast.
Driving adoption of new technologies in biopharmaceutical manufacturing
Authors: Schaefer Gene , Balchunas John , Charlebois Timothy , Erickson John , Hart Roger , Kedia Sandeep B. , Lee Kelvin
Published: November 2022

The challenge of introducing new technologies into established
industries is not a problem unique to the biopharmaceutical industry.
However, it may be critical to the long-term competitiveness of
individual manufacturers and, more importantly, the ability to deliver
therapies to patients. This is especially true for new treatment
modalities including cell and gene therapies. We review several barriers
to technology adoption which have been identified in various public
forums including business, regulatory, technology, and people-driven
concerns. We also summarize suitable enablers addressing one or more of
these barriers along with some suggestions for developing additional
synergies.
Exosomes of the nervous system: the double-edged sword
Authors: Singh Varsha , natesan raja
Published: November 2022

Neurodegenerative disorders continue to place the biggest strain on
healthcare systems. Basic research is still being done on the molecular
foundations of disease pathogenesis and initiation. Exosomes have only
lately been connected to the onset and development of various
neurodegenerative disorders. Exosomes, tiny extracellular vesicles with
a bilipid coating around them, were once thought to be cellular trash
that could help track the onset of neuro diseases. These ≤150
nm-diameter nano-vesicles contain significant non-coding RNA like
circRNA, lncRNA, and miRNA; functional mRNA; and specific proteins and
lipids. These vesicles can be used as a diagnostic indicator for early
disease detection because the composition of exosomes is known to differ
depending on their source and target cells. This article reviews
exosomes’ biogenesis, composition, and roles in neuronal development,
mental illness, and degenerative disorders. We also emphasize the
possible use of neuronal exosomes as therapeutics for neurodegenerative
diseases.
Software components selection: An optimized selection criterion for component-based software engineering (CBSE)
Authors: nabot ahmad
Published: November 2022

Component-based software engineering (CBSE) is becoming the frequently
used approach for software development concerning time and cost
constraints. While most people’s lifestyle depends on the use of
software applications, the development cost and time of software
applications are becoming more difficult to achieve. Also, high-quality
and competent applications that fit users’ needs became essential.
Therefore, most software development organizations are reusing
commercial-off-the-shelf (COTS) to reduce development costs and time.
However, most organizations and developers face problems selecting
components that fit customer needs to integrate with the target system.
So, decisions regarding software component selection are hard to
consider regarding the entire quality of the software system. This study
aims to investigate the most important matters to software industry
practitioners and experts involved in component selection. First, the
author asked the practitioners to select the most important quality
criteria for an online bookstore from a list by providing their
subjective judgment and evaluation grades; after that, utilizing the
evidential reasoning (ER) approach for software component selection
problems due to its ability to analyze decisions with multilevel
evaluations and information uncertainty. Moreover, the main features of
the ER approach, such as weight normalization, probability assessment,
dealing with uncertainty, and utility intervals, offer several
advantages for COTS selection problems, including cost and time
minimizing, improved software reliability, effectiveness, and
efficiency. This study concentrated on assessing the quality criteria
for an online bookstore using the ER approach. Analysis results are
provided depending on the computational steps of this approach. Finally,
the findings show the rank of the four components according to their
weights, evaluation grades, and belief degrees for the selection.
Database Creator for Protein/Peptide Mass Analysis, DC-PPMA: A novel standalone computational tool for simplifying the analysis of MS/MS data to identify protein/polypeptide sequences by different proteomic approaches
Authors: Pandeswari Pandi Boomathi , Emerson Isaac , Sabareesh Varatharajan
Published: November 2022

Rationale: Proteomic studies typically involve use of different types of
softwares for annotating experimental tandem mass spectrometric data
(MS/MS) and thereby simplify the process of peptide and protein
identification. For such annotations, these softwares calculate the m/z
values of the peptide/protein precursor and fragment ions, for which a
database of protein sequences must be provided as input file. The
calculated m/z values are stored as another database, which the user
usually cannot view. ‘Database Creator for Protein/Peptide Mass
Analysis’ (DC-PPMA) is a novel standalone software that can create
custom databases and the user can view the custom database containing
the calculated m/z values of precursor and fragment ions. Methods:
Python language was used for implementation and the graphical user
interface was built with Page/Tcl, making this tool more user-friendly
and easier to analyze. DC-PPMA is freely available at
https://vit.ac.in/PPMA/. Results: DC-PPMA contains three modules.
Protein/peptide sequences as per user’s choice can be entered as input
to the first module for creating custom database. In the second module,
m/z values must be queried-in, which are searched within the custom
database to identify protein/peptide sequences. The third module is
suited for peptide mass fingerprinting, for which data arising from both
ESI and MALDI MS can be utilized. Conclusions: Mass spectral data
acquired from any proteomic approach: bottom-up, middle-down and
top-down can be interrogated with DC-PPMA. A major facet of DC-PPMA is
that the user can ‘view’ the custom database containing the m/z values
of the precursor ions (e.g., proteolytic peptides) and the respective
fragment ions (e.g., b & y ions), prior to the database search. The
feature of ‘viewing’ the custom database cannot only be helpful for
better understanding the search engine processes; but also, for
‘designing multiple reaction monitoring (MRM) methods’.
Post-translational modifications and protein isoforms too can be
analyzed.
A Study on the High-Resolution Full Frequency Shielding Effectiveness Testing Method
Authors: Wu Jian-fei , Lu Yanfang , YIfei Zheng , Li Yang , Zheng Long-fei , Du Guanxiang
Published: November 2022

The shielding effectiveness is a key index to measure the performance of
electromagnetic protective materials However, the traditional shielding
effectiveness testing methods exist many losses, there by the
experimental data varying under different test conditions. This paper
aims to provide a novel NV-center based optical high-resolution
shielding performance testing method, a method that may directly provide
the distribution of the electromagnetic field on the surface of the
electromagnetic shielding material. This method was used to test the
shielding performance of two different electromagnetic shielding
materials, and comparison with the surface scan method has proved the
feasibility and reliability of the optical high-resolution test method,
providing a new idea for testing the effectiveness of electromagnetic
shielding materials more accurately and effectively.
“Because God Has Given Us the Power of Reasoning”: Intellectuals, the Eritrean Muslim League, and Nationalist Activism, 1946–1950
Authors: Venosa Joseph L.
Published: November 2022

This article discusses the rise of Eritrean nationalism in the context of Muslim intellectual acüvism during the later penod of the Bntish Military Administration (BMA). It argues that many of the leading members of the pro-independence Muslim intelligentsia, defined in thh article broadly as the fluid group of waters, Eritreans within the former Italian colonial civil service, and religious scholars serving within or associated with the Eritrean Muslim League, contributed to the naüonaUst movement by taking advantage of the extensive "Islamic social capital" across the region. Using Muslim League publicaüons, personal testimonies, British archival sources, and secondary literature, tfús article will show that throughout the period in question, proactive members of the intelligentsia helped strengthen Muslim civil society while they engaged in broader struggles aimed at achieving social reform and establishing cooperative relationships within the broader nationalist constituency. Their efforts had a tremendous influence on the overall trajectory of nationalism among both League leaders and the orgamzation’s general membership.
Notes on Preparing a Critical Edition of the Śər‘atä mängəśt
Authors: Kropp Manfred
Published: November 2022

The Śər’atä mängəśt is a collection of historical notes, descriptions of important ceremonies at the royal Ethiopian court, and regulations for court protocol and practices pertaining to law suits. The text exists in several different versions in a fairly large number of codices where it is often placed in front of the so-called Short Chronicle of the Ethiopian Kings. While I was working on a synoptical edition of these versions, the intertextual (and material) links to other sources of the Ethiopian historical tradition (chronicles, juridical documents, etc.) became clear, and it was possible to identify the authors, redactors, and compilers of these texts as counselors and judges at the royal court. The Śər’atä mängəśt, this professional group’s vade mecum, was written and modified as a function of changes in the political and social situation.
Learning Leadership: Lincoln at the Lyceum, 1838
Authors: Ray Angela G.
Published: November 2022

Re-creating a history of the Young Men’s Lyceum of Springfield, Illinois, in the late 1830s, this essay situates Lincolns 1838 Lyceum Address within the immediate context of its delivery. Then, by comparing the published text of Lincolns lecture with lectures delivered by two other Springfield lawyers at the same venue in 1838 and 1839, the essay argues for a revised understanding of Lincolns Lyceum Address as it relates to his political development, his psychological state, and his compositional practices.
Debating the Great Emancipator: Abraham Lincoln and our Public Memory
Authors: Wilson Kirt H.
Published: November 2022

In this essay I analyze the debate over Abraham Lincoln’s role in the emancipation of African American slaves. Speaking both to contemporary public memory and the evidence of history, I contend that when Lincoln discussed or wrote about emancipation between 1860 and 1863, his rhetoric exhibited a dialogic form that shifted responsibility from the president to congressional leaders and common citizens. I conclude that Lincoln’s dialogic rhetoric does not signal his opposition to emancipation but rather his deep belief that emancipation would become meaningful only after the considered deliberation and action of the American people.
A Newly Discovered Manuscript Map by Antoine-Simon Le Page du Pratz
Authors: Sayre Gordon M.
Published: November 2022

En 2007, la bibliothèque du Congrès a acquis une carte manuscrite de la main d’Antoine-Simon Le Page du Pratz, colon de la Louisiane française et auteur de l’Histoire de la Louisiane (1758). La carte a été faite peu après le retour de l’auteur en France en 1734. Pour les historiens de la colonie française et de sa cartographie, cette nouvelle carte est très intéressante. D’abord, elle ne fait aucune référence à Moncacht-apé, un indien Yazoo qui, selon les œuvres du Pratz des années 1750, a voyagé du Mississippi à l’Océan Pacifique bien avant Lewis et Clark. De plus, la nouvelle carte suggère que Le Page du Pratz consultait le cartographe Jean-Baptiste Bouguignon d’Anville quand il était en débat avec les cartographes de la famille Delisle en 1752-53.
Unequal Transitions: Two Métis Women in Eighteenth-Century Île Royale
Authors: Lane Jonah Anne-Marie
Published: November 2022

Cette étude établit une comparaison entre deux françaises coloniales nées dans deux communautés périphériques d’Acadie au XVIIIe siècle (aujourd’hui la Nouvelle Écosse péninsulaire et le sud du Nouveau Brunswick). Ces deux femmes, qui avaient des pères européens et des mères d’origines mixtes, européennes et amérindiennes, ont déménagé pour s’installer dans la colonie française de l’île Royale (aujourd’hui le Cap-Breton), puis se sont mariées dans la société de ce centre colonial administratif, militaire et commercial. L’une a fini ses jours comme femme d’affaires accomplie et épouse d’officier, intégrant ainsi l’élite coloniale. L’autre fut l’objet d’un processus juridique qui mit fin à son mariage avec un officier. Les ressemblances entre ces femmes et les différences entre leurs sorts démontrent la nature contingente des idées que se faisaient les français coloniaux des notions de race, de classe, et de sexe. Durant leur vie, l’interprétation et la manipulation de ces facteurs qui constituent l’identité par ces femmes, leurs familles et les autorités coloniales, ont déterminé la réussite des efforts qu’elles ont fait pour passer d’une société coloniale à une autre.
Traître au colonialisme? The Georges Boudarel Affair and the Memory of the Indochina War
Authors: Edwards M. Kathryn
Published: November 2022

Le 13 février 1991, le Professeur Georges Boudarel a été interpelé, lors d’un congrès au Sénat sur "L’actualité vietnamienne," par un groupe d’anciens combattants, qui l’ont accusé d’avoir été ’commissaire politique’ dans le camp Viêt minh 113 et d’être ainsi responsable d’un nombre élevé de morts. "L’affaire Boudarel" a éclaté, provoquant un débat public intense, centré non seulement sur les actions de Boudarel (qu’il qualifiait lui-même d’anticoloniales), mais sur la nature de la guerre d’Indochine et les mérites du projet colonial. La complexité de la guerre, qui était à la fois une guerre coloniale et un point chaud de la guerre froide, a retenti dans ces débats, les défenseurs de Boudarel insistant sur la nature coloniale du conflit, tandis que ses détracteurs ne reconnaissaient que l’objectif anticommuniste des forces françaises. Cet article analyse les débats concernant la nature de la guerre, ainsi que les enjeux médiatiques de la question de la ’mémoire’ de la guerre d’Indochine, avant d’élargir la discussion afin de replacer l’affaire Boudarel dans le contexte plus large de la question mémorielle en France.
Après l’Empire: Violences institutionnelles dans le Djibouti colonial tardif
Authors: Imbert-Vier Simon
Published: November 2022

This article presents and analyzes a set of institutional manifestations of violence that took place in a late colonial situation—the French Territory ofAfars and Issas from 1966 up to its independence in 1977—with the announced aim of blocking migratory movements and maintaining French sovereignty over the territory. The present article describes this violence mostly performed by military forces (“barrage,” endless physical control of the inhabitants of the autochthonous areas, evictions, indexing, etc.), and the way it was legitimized by an identity assignation process, the methods and ideological resources of which are explained. This example from a recent past shows the stakes and methods of migration control, and the possible infringement on the rule of law it can cause in a postcolonial state. Its study, however, shows that the colonial situation is not sufficient in itself to explain this use of extraordinary coercive procedures. They participate in the construction of national identity, but are also responsible for the difficulties of its construction. This situation is part of the evolution of the technologies of institutional violence after World War II, mostly applied to “foreigners.”
Cosmopolitisme impérial et nationalisme: La vie circulaire d’Albert Rakoto Ratsimamanga (1907–2001)
Authors: Galibert Didier
Published: November 2022

Albert Rakoto Ratsimamanga arrived in France with the Malagasy delegation to the Colonial Exposition of 1931. The founder of the Association des Étudiants d’origine malgache (1934) and of the Mouvement démocratique pour la Rénovation de Madagascar (1946), he was a physician and a biologist, and he joined the Centre national de la Recherche Scientifique (CNRS) as a senior researcher, pursuing his scientific career and his nationalistic involvement in the postwar Paris of the 1950s. He was the first ambassador of the Malagasy Republic to France, for 13 years, before he returned to settle permanently in Madagascar in 1975. The transversality of his life course can be interpreted along several lines: chronologic straddling of this diasporic projection with political independence, loyalty to an aristocratic ethos with a progressive rallying to a republican conception of citizenship, and imperial circulation of knowledge attested to by the foundation of the Institut malgache de Recherches appliquées in 1957. Moreover, the paper points out the heuristic significance of the memorialization of his part as the nation’s father, standing up for the hypothesis of a retrospective enlightening of the state’s transmission continuum, within an ideological and institutional framework that was constantly being negotiated with the former colonial power.
Moving Day in the House Divided: Contextual Substantiation and Constitutional Unionism in Vice President John C. Breckinridge’s Address on the Removal of the Senate to its New Chambers, January 4, 1859
Authors: Griffin Charles J. G.
Published: November 2022

This essay examines the speech delivered by Vice President John C. Breckinridge on the occasion of the removal of the United States Senate to its new chambers on January 4, 1859. Drawing upon Kenneth Burkes concept of contextual substance, I argue that Breckinridge constructs the Senate’s transition to its new quarters as a defense of constitutional unionism, a conservative political ideology holding that the survival and prosperity of the Union depended upon its continued adherence to the compromises enshrined in the Republics founding document. In an age dominated by increasingly strident rhetorical extremes, constitutional unionism represented a beleaguered vision of Union that was soon eclipsed by the Civil War and today is all but forgotten. Analysis of the Removal Address thus illumines the rhetoric of an important yet neglected political ideology while disclosing the rhetorical "alchemy" by which geometric, familial, and directional substance reconcile continuity and change in leave-taking discourse.
"Nigh unto Death": NDE Research and the Book of Mormon
Authors: Christensen Kevin
Published: November 2022

This article suggests that contemporary near-death research casts light on several episodes in the Book of Mormon. Alma’s conversion while "nigh unto death" fits a common pattern of experience. Modern researchers have noticed distinctive aftereffects among NDErs. In the Book of Mormon, both Alma and the resurrected Christ demonstrate these aftereffects. Lehi’s dream invites comparison with the otherworld journey literature of many nations. Nephi’s interpretation of Lehi’s dream casts light on the tension between the literal and the symbolic elements of visionary experience. Finally, just as accurate out-of-body observations made by NDErs argued for the reality of their experiences, so the testable aspects of the Book of Mormon give Joseph Smith a significance apart from others who may have experienced similar visions.
Basic Methodological Problems with the Anti-Mormon Approach to the Geography and Archaeology of the Book of Mormon
Authors: Hamblin William J.
Published: November 2022

Anti-Mormon criticisms of the Book of Mormon are frequently based on a questionable set of assumptions concerning the nature of historical and archaeological evidence, the role of governing presuppositions, and the nature of historical proof. Using arguments found in a recent anti-Mormon critique by Luke Wilson as a foundation, this article analyzes issues of the difficulties of reconstructing ancient geographies, problems with the discontinuity of Mesoamerican toponyms, the historical development of the idea of a Limited Geography Model, and difficulties of textual and artifactual interpretation when trying to relate the Book of Mormon to archaeological remains.
Hubris and Atē: A Latter-day Warning from the Book of Mormon
Authors: Draper Richard D.
Published: November 2022

Civilizations fall due to complex pressures, but the Book of Mormon points to one sin which assisted if not drove the demise of both the Nephite and Jaredite peoples. This sin was pride. This essay ties pride to the Old World concepts of hubris and atē as a means of revealing the dynamic nature of this sin and exploring its deadly character. It shows that pride leads to hubris, the attempt by individuals and nations to become a law unto themselves, and that the consequence of hubris is atē, a spiritual blindness that impels the individual or society toward its doom. The paper warns the Latter-day Saint about this vice.
Book of Mormon Event Structure: The Ancient Near East
Authors: Smith Robert F.
Published: November 2022

The Book of Mormon annals open in an ancient Near Eastern context. The archaeological-historical context is carefully outlined here within a systematic chronology that is tied to fixed, absolute dates of recorded astronomical events—particularly those from cuneiform eponym calendars. The resultant matrix allows those early Book of Mormon events to be understood in a rational, familiar, and meaningful way, i.e., in a biblical context. In addition, an excursus is devoted to understanding the Arabia of the Book of Mormon as the Lehite exiles must have known it. Throughout it is clear that the world depicted by the Book of Mormon dovetails remarkably well with what we know of the ancient Near East.
Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
Authors: Luan Danny , Dadpey Benyamin , Zaid Jessica , Bridge-Comer Pania E. , DeLuca Julia H. , Xia Wenmin , Castle Joshua , Reilly Shannon M.
Published: November 2022

Complex bidirectional cross talk between adipocytes and adipose tissue immune cells plays an important role in regulating adipose function, inflammation, and insulin responsiveness. Adipocytes secrete the pleiotropic cytokine IL-6 in response to both inflammatory and catabolic stimuli. Previous studies have suggested that IL-6 secretion from adipocytes in obesity may promote adipose tissue inflammation. Here, we investigated catabolic stimulation of adipocyte IL-6 secretion and its impact on adipose tissue immune cells. In obesity, catecholamine resistance reduces cAMP-driven adipocyte IL-6 secretion in response to catabolic signals. By restoring adipocyte catecholamine sensitivity in obese adipocytes, amlexanox stimulates adipocyte-specific IL-6 secretion. We report that in this context, adipocyte-secreted IL-6 activates local macrophage STAT3 to promote Il4ra expression, thereby sensitizing them to IL-4 signaling and promoting an anti-inflammatory gene expression pattern. Supporting a paracrine adipocyte to macrophage mechanism, these effects could be recapitulated using adipocyte conditioned media to pretreat bone marrow–derived macrophages prior to polarization with IL-4. The effects of IL-6 signaling in adipose tissue are complex and context specific. These results suggest that cAMP-driven IL-6 secretion from adipocytes sensitizes adipose tissue macrophages to IL-4 signaling.
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Authors: Guo Zheng , Kasinathan Devi , Merriman Chengfeng , Nakayama Maki , Li Hua , Li Huilin , Xu Cheng , Wong G. William , Yu Liping , Golson Maria L. , Fu Dax
Published: November 2022

Type 1 diabetes (T1D) is a disease in which autoimmune attacks are directed at the insulin-producing β-cell in the pancreatic islet. Autoantigens on the β-cell surface membrane are specific markers for molecular recognition and targets for engagement by autoreactive B lymphocytes, which produce islet cell surface autoantibody (ICSA) upon activation. We report the cloning of an ICSA (mAb43) that recognizes a major T1D autoantigen, ZnT8, with a subnanomolar binding affinity and conformation specificity. We demonstrate that cell-surface binding of mAb43 protects the extracellular epitope of ZnT8 against immunolabeling by serum ICSA from a patient with T1D. Furthermore, mAb43 exhibits in vitro and ex vivo specificity for islet cells, mirroring the exquisite specificity of islet autoimmunity in T1D. Systemic administration of mAb43 yields a pancreas-specific biodistribution in mice and islet homing of an mAb43-linked imaging payload through the pancreatic vasculature, thereby validating the in vivo specificity of mAb43. Identifying ZnT8 as a major antigenic target of ICSA allows for research into the molecular recognition and engagement of autoreactive B cells in the chronic phase of T1D progression. The in vivo islet specificity of mAb43 could be further exploited to develop in vivo imaging and islet-specific immunotherapies.
Efficacy of adding an interspace block to the posterior knee for perioperative pain in total knee arthroplasty: a randomized controlled trial
Authors: Chatmaitri Swist , Tangwiwat Suwimon , Halilamien Pathom , Ruangsomboon Pakpoom , Pornrattanamaneewong Chaturong , Chareancholvanich Keerati , Narkbunnam Rapeepat
Published: November 2022

Background and purpose: The interspace between the popliteal artery and the capsule of the posterior knee (IPACK) block is a novel anesthetic technique for total knee arthroplasty (TKA). Our objective was to compare the effect of IPACK and adductor canal block (ACB) and periarticular injection (PAI), relative to ACB and PAI only, from baseline to postoperative day 3, in patients undergoing unilateral primary TKA.Patients and methods: This was a single-center, double-blinded, randomized controlled trial. Adults over the age of 50 who were scheduled for unilateral primary TKA were enrolled. They were randomly assigned to ACB and PAI block (control group), or ACB, PAI, and IPACK block (IPACK group). The primary outcome was mean pain at rest during 24–48 hours post-operation using a numerical rating scale (0–10). We also investigated opioid use and ambulation pain.Results: 89 patients were evaluated, 45 from the control group and 44 from the IPACK group. Despite slightly higher mean pain score at rest in the control group, no statistically significant difference was found during 0–24 hours (0.13; 95% CI –0.19 to 0.46), 24–48 hours (0.42; CI –0.06 to 0.89), and 48–72 hours (0.35; CI 0.00 to 0.69) postoperatively as well as in maximum pain scores at rest. Neither pain during ambulation nor the number of opioids used differed between the trial groups at any given time point.Conclusion: The addition of the IPACK block to ACB and PAI did not reduce postoperative pain intensity or opioid usage. Therefore, IPACK block may not offer any benefit for pain management in patients undergoing unilateral primary TKA who are already receiving ACB and PAI.
Caffeine and Camellia sinensis enhance cognition and decrease acetylcholinesterase activity in scopolamine-induced memory loss in female Swiss mice
Authors: Imam-Fulani Aminat Omolola , Ogungbemi Oluwajuwonlo Justina , Olajide Lateefat Omotoyosi , Ojulari Lekan Sheriff , Adedeji Tayyib Adekunle , Ibrahim Maryam Abidemi , Emaikwu Emmanuel , Ayinla Fatima , Fafure Adedamola Adediran
Published: November 2022

Caffeine and Camellia sinensis (green tea) has been known to have positive effect on memory. The present study investigated the possible effect of caffeine and green tea co-administration on oxidative stress markers, inflammatory marker and acetylcholine esterase activity in scopolamine-induced memory loss in female Swiss mice. Memory behavioral tests using Y-maze and Morris water maze was carried out, followed by oxidative stress biomarkers, acetylcholinesterase activity and Tumor Necrosis Factor alpha (TNF-α) evaluation from the mice brain tissues after caffeine and green tea administration. Scopolamine administered intraperitoneally at a dose of 1mg/kg Body Weight (BW) for 7 days significantly reduced the percent alternation of the mice in Y-maze thus, increased acetylcholinesterase activity and increased TNF-α level. However, caffeine administered orally at a dose 50mg/kg BW and green tea administered orally at a dose of 60mg/kg BW increased the percent alternation significantly, reduced acetylcholinesterase activity and reduced the TNF alpha level significantly. Oxidative stress markers evaluated GSH and MDA, showed no significant difference across all groups. These findings showed scopolamine has a deteriorating effect on cognition by increasing acetylcholinesterase activities thus mopping out acetylcholine at a faster rate. However, caffeine and green tea singly and in combination restored cognition, reduced acetylcholinesterase activity and restored TNF-α level. The neuroprotective effect of caffeine and green tea was compared to that of Donepezil, an established cognition enhancing drug and the effect was agonistic. The ability of caffeine and green tea to reduce acetylcholinesterase activity could be the mechanism for the ability to enhance memory. The ability of these compounds in restoring TNF alpha level also further potentiates their neuroprotective capability.
Analisis Struktur Geologi Berdasarkan Data Gravitasi Menggunakan Metode Second Vertical Derivative (SVD) Pada Lapangan Panas Bumi ”X”
Authors: Ibrahim Mochammad Malik , Utami Pri , Raharjo Imam Baru
Published: November 2022

Lapangan panas bumi ”X” merupakan salah satu lapangan panas bumi yang berada pada Provinsi Sulawesi Utara yang dikelola oleh PT. Pertamina Geothermal Energy. Penelitian ini melakukan analisis struktur geologi menggunakan metode second vertical derivative (SVD) dari hasil proses derivatif atau turunan kedua terhadap sumbu z pada anomali Bouguer lengkap dengan menggunakan persamaan Laplace’s. Anomali second vertical derivative (SVD) digunakan untuk mengidentifikasi dan analisis struktur geologi pada daerah penelitian. Anomali ini menunjukkan bidang – bidang yang mengalami penurunan maupun kenaikan akibat dari kontras densitas batuannya. Peta anomali second vertical derivative (SVD) mempunyai persebaran nilai anomali -5,5 hingga 3,5 mGal/km2. Nilai anomali 0 mGal/km2 antar interface maksimum dan minimum menunjukkan adanya batas bidang struktur sehingga dilakukan interpretasi struktur geologi pada anomali second vertical derivative (SVD) sesuai dengan informasi kelurusan dan struktur geologi dari peta geologi daerah penelitian.
Analisis Spasial Tingkat Kerawanan Banjir di Kecamatan Teluk Ambon Baguala, Kota Ambon
Authors: Rakuasa Heinrich , Sihasale Daniel A , Mehdila Marhelin C , Wlary Anelia P
Published: November 2022

Intensitas curah hujan yang tinggi hingga meluapnya DAS Waisalak yang mengakibatkan bencana banjir melanda Kecamatan Teluk Ambon Baguala. Analisis spasial untuk identifikasi tingkat kerawanan banjir sangat diperlukan untuk memberikan informasi sebagai langkah awal upaya mitigasi bencana banjir ke depannya. Penelitian ini bertujuan untuk menganalisis secara spasial tingkat kerentanan banjir dan permukiman yang terdampak di Kecamatan Teluk Ambon Baguala. Metode yang digunakan yaitu pembobotan dan skoring atau weighted scoring dilakukan setelah proses klasifikasi nilai dalam tiap variabel. Penentuan bobot dan skor pada penelitian ini bersifat expertise judgment yaitu mengambil pendapat para ahli atau penelitian sebelumnya. Hasil pembobotan kemudian dilakukan dioverlay untuk mendapatkan peta kerawanan banjir. Hasil penelitian menunjukkan bahwa tingkat kerawanan banjir didominasi oleh tingkat kerawanan rendah seluas 3.667,01 ha dan hasil observasi di lapangan menunjukkan bahwa luas permukiman yang terdampak banjir yaitu 581,36 ha.  Hasil penelitian diharapkan dapat dijadikan dasar dalam upaya mitigasi bencana banjir ke depannya guna meminimalisir kerugian, baik korban jiwa maupun kerusakan fisik di Kecamatan Teluk Ambon Baguala.
Analisis Kemampuan Pemahaman dan Self Esteem Matematis melalui Pembelajaran E-Learning Berbasis Portal Rumah Belajar
Authors: Kurnia Aam , Mansor Mohd Asyraf
Published: November 2022

Belajar matematika memerlukan kecakapan untuk berpikir dan beralasan secara sistematis untuk menyelesaikan soal-soal baru dan mempelajari ide-ide baru yang akan dihadapi oleh peserta didik dimasa yang akan datang. Tujuan penelitian ini adalah untuk menganalisis peningkatan kemampuan pemahaman dan self-esteem matematis siswa dengan sampel secara purposif sampel tiga kelas VIII siswa SMP Bina Mandiri Sukamanah Kab. Garut tahun ajaran 2020/2021. Metode yang digunakan adalah metode campuran tipe konvergen. Instrumen tes yang digunakan adalah pre-test dan post-test sedangkan untuk instrumen non tes adalah lembar observasi dan angket. Data dianalisis menggunakan uji N-gain, uji Kruskal Wallis H dan uji ANOVA dua jalur. Hasil penelitian adalah: (1) peningkatan kemampuan pemahaman matematis siswa yang menggunakan e-learning portal rumah belajar lebih baik daripada siswa yang menggunakan model PBL dan metode ceramah dilihat dari data keseluruhan dan KAM; (2) tidak terdapat interaksi antara pembelajaran yang menggunakan e-learning portal rumah belajar, model PBL dan metode ceramah dengan KAM terhadap peningkatan kemampuan pemahaman matematis siswa; (3) self-esteem matematis siswa yang menggunakan pembelajaran e-learning portal rumah belajar lebih baik daripada yang menggunakan model PBL dan metode ceramah dilihat dari keseluruhan dan KAM.
Pengembangan Bahan Ajar Berbantuan Kaizala Berorientasi pada Kemampuan Komunikasi Matematis dan Kemandirian Belajar Siswa
Authors: Kusmayati Kusmayati
Published: November 2022

Penelitian pengembangan bahan ajar ini bertujuan untuk: (1) Mengembangkan bahan ajar materi program linear berbasis mobile learning dengan berbantuan aplikasi kaizala yang layak digunakan untuk pembelajaran; (2) Menganalisis kemampuan komunikasi matematis siswa yang memperoleh pembelajaran menggunakan bahan ajar program linear berbasis mobile learning; (3) Menganalisis kemandirian belajar siswa yang memperoleh pembelajaran menggunakan bahan ajar program linear berbasis mobile learning; (4) Menganalisis adanya hubungan antara kemampuan komunikasi matematis dan kemandirian belajar. Metode yang digunakan adalah Reaserch & Development dengan menggunakan model pengembangan ADDIE. Penelitian ini dilakukan pada 24 orang siswa di SMK Kimia Permentasi Bandung. Instrumen dalam penelitian ini menggunakan wawancara, angket ahli materi, angket ahli media, angket respon siswa, tes kemampuan komunikasi matematis dan angket kemandirian belajar siswa. Hasil penelitian menunjukan bahwa: (1) Bahan ajar pada materi program linear termasuk kategori sangat layak dari ahli materi, sangat layak dari ahli media, dan sangat kuat untuk hasil analisis respon siswa; (2) Kemampuan komunikasi matematis termasuk dalam kategori tinggi setelah menggunakan bahan ajar yang dikembangkan; (3) kemandirian belajar siswa termasuk dalam kategori “sebagian besar” siswa telah mandiri dalam belajar setelah menggunakan bahan ajar yang dikembangkan; (4) Terdapat hubungan positif antara kemampuan komunikasi matematis dan kemandirian belajar siswa.
The Role of Organizational Commitment as a Mediation Variable on The Effect of Job Stress on Turnover Intention at Hotel Dafam Savvoya Seminyak Badung, Indonesia
Authors: Karinuada I Kadek Gede , Suwandana I Gusti Made
Published: November 2022

Dafam Group was only formed in 2010 and in 2011 changed its name to Dafam Hotel Management, but at the end of 2013 it was able to record an income of IDR 180 billion per year. This success cannot be separated from the hands of Dinign Billy Dahlan as President Director of Dafam Hotel Management in managing its business line, which is not only engaged in the hospitality sector, but also in other fields such as hotel management, entertainment, and property. The purpose of this study was to determine the role of organizational commitment on the effect of job stress on turnover intention at Dafam Savvoya Hotels, Seminyak, Badung, Bali. The sample used in this study was 50 people, using a saturated sampling technique. Data collection obtained using questionnaire. Data analysis in this study uses path analysis. The results show stress has a positive effect on turnover intention meanwhile job stress and organizational commitment have negative effect on turnover intention. Organizational commitment able mediate the effect of job stress on turnover intention.
The Experiences on Attempts and Challenges of Providing Free or Affordable Universal Health Care in Developing Countries: Review of Kenyan Situation
Authors: Malusha James Mwashembe
Published: November 2022

Ensuring the availability of quality and affordable health care for all citizens is a primary goal of every government. However, how they do it differs from country to country, but the bottom line is that many countries especially developing ones have challenges in providing accessible quality health care to all their citizens. Among the numerous approaches to providing health care to all, universal health care is the newest ‘kid in the block’ approach. Kenya has made numerous attempts to provide free or affordable health care to citizens but has encountered numerous challenges in the process. The approach has been mainly through health care reforms such as universal or categorical free health care or the introduction of health insurance and the expansion of its coverage. In Kenya, health care had been free since independence. Achieving quality health care requires concerted efforts aimed at diversifying and strengthening financing mechanisms and schemes as well as eliminating inefficiencies in health care. Moreover, there is a need to boost economic growth so as to raise GDP and income per capita which will go a long in improving the affordability of health care. This review article has looked at various mechanisms and challenges of financing health care in developing countries, with a particular focus on Kenya, in order to achieve universal health care. Nonetheless, there is a need for further research and comparative analysis on the cost-effectiveness of various financing mechanisms for health care in different countries. This is vital considering that health care is a right to all people.
The Impact of Time on Learning Outcomes: Lessons from the Delivery of High School Mathematics Curriculum in Ghana
Authors: Mensah Farouq Sessah , Yarkwah Christopher
Published: November 2022

A student’s productive learning time is proportional to the length of   time they spend working during their lessons. However, it is important to remember that the issues with educational time are not just about optimizing “in-school time.” The study is prompted by the time spent in school and how it impacts students learning outcomes in core mathematics, considering two different year groups for the May/June 2013 West African Senior School Certificate Examination (WASSCE-standardized examination written by Anglophonic countries of West Africa (Ghana, Nigeria, Sierra Leone, Liberia, and the Gambia)). The study compares students’ learning outcomes in the May/June 2013 WASSCE. The study uses a descriptive survey design and conveniently collected data from 10 Senior High Schools (SHSs) in the Central Region of Ghana. The results of the study showed no statistically significant difference in core mathematics grades between students who spent four years and those who spent three years in SHS. Thus, time is not the sole determinant of a student’s learning outcome, as has been suggested by some studies.
Induction Motor Based Speed and Direction Controller
Authors: Al Rakib Md. Abdullah , Rahman Md. Moklesur , Hossain Md. Miraj , Rahman Md. Ashiqur , Samad Mousume , Abbas Fysol Ibna
Published: November 2022

Induction motors are widely employed in a variety of sectors, from household gadgets to industrial machinery. This mandates the deployment of an effective and safe speed control device. Induction motors may also run in either direction, which is beneficial in a variety of applications. The Induction Motor Speed and Direction Controller Project are designed to regulate the induction motor's speed and direction. Induction motors run on straight AC lines, and the amount of power they receive determines how fast they revolve. Through AC driver circuitry, we may regulate the power of the AC line to change the speed of the induction motor. A microcontroller from the Atmega family is utilized to provide PWM power to an opto-coupler, which drives the TRIAC that supplies power to the induction motor. The microcontroller receives instructions via a mobile phone connection to the system. The mobile phone sends DTMF signals to the system, which the system recognizes and responds to appropriately. A button is used to raise the speed of the induction motor, a button to change direction, and a button to lower the speed of the induction motor, according to the video. On the LCD, the entire procedure may be observed in real time. In this way, this project demonstrates how to control the speed and direction of an induction motor.
Electric Resistivity for Evaluating Groundwater Potential Along the Drainage Zones In the Part of Jos North, Plateau State, Nigeria
Authors: Nanfa Changde A. , Aminu Mu’awiya Baba , Christopher Simon D. , Akudo Ernest O. , Musa Kizito O. , Aigbadon Godwin O. , Millicent Okiyi I.
Published: November 2022

The research area Jos Plateau is located in Nigeria's north-central region. Because of the presence of hills and mountains, it is a typical Basement Complex topography, making access to potable water difficult. Data Collection was carried out in two stages namely: Desk Study and Field Geophysical Surveys. The desk study involved a review of published work on the area as well as sourcing of maps. An effort was put in place for a geotechnical procedure using both geophysical and geological approaches. With the help of previous works of literature about the area, background information was obtained. This was followed by a reconnaissance survey. The topographical map (NARAGUTA SHEET 168NE) was obtained. The drainage pattern was observed and traced. The boundary of the research work was delineated between latitudes 90 30ʹ 00ʺ N to 100 00ʹ00ʺ N and longitudes 80 30 ʹ 00 ʺ E to 90 00 ʹ E. The map was partitioned into grids for the purpose of locating VES locations (Vertical Electrical Sounding). To obtain the underlying information needed for this research, resistivity sounding was used to collect data throughout such river channels. The sounding and data were collected using the Nile Drill tech terameter. A lineament map was created using satellite images, and a hydro geophysical survey was conducted along these drainage patterns. The structural expressions were compared to the characteristics revealed by the geophysical survey. Due to the changes that occur between beds of dry, water-bearing, sediment, different lithology, and weathering rocks, vertical profiles and their characteristics were determined. The data were analyzed, processed, plotted, and interpreted. Various cross-sections were drowned and correlated. Despite the fact that the sounding was carried along river channels, it revealed generally that the whole study area can be said to be of low groundwater potential.