bluuebunny/crossref_metadata_2025 huggingface dataset:
"SLIDING FRICTION BETWEEN AMORPHOUS COTTON FIBER AND CHROMIUM SURFACES: A MOLECULAR DYNAMICS STUDY "
Authors:   ", YAN ZHE ,   School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China", JIANG KAIXIANG ,   "School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China", FAN PENGWEI ,   "School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China", FANG WENJUAN ,   "School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China", ZHU CUNZHOU ,   "School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China", PAN PENG ,   "School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China", CAO HUI ,   State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China, ZHANG YOUQIANG ,   "School of Mechanical and Electrical Engineering, Key Laboratory of Modern Agricultural Engineering, Tarim University, Alar 843300, China"
Published: May 2022

"It is challenging to experimentally determine the micro-friction mechanism of cotton fiber and metal in the sliding process. The influence of load and temperature on the interface behavior during dry friction between amorphous cotton fiber and chromium, the contact interface evolution and friction coefficient are studied using reactive molecular dynamics. The simulation results show that chromium–oxygen bonds are formed on the contact interface of the friction system during the sliding process. Furthermore, the relationship between friction coefficient, temperature, and load varies with the mechanical state of cotton cellulose. The relationship is positive when the cotton cellulose is in the glassy state. However, when cotton cellulose is in a highly elastic state, its friction coefficient is negatively related to the load. This study systematically evaluated the effects of temperature and load on the slip process from the atomic scale, provided a reason for the wear of the hard materials of the friction pair, and provided theoretical support for the study of this type of friction mechanism."
ELECTROSPUN SODIUM ALGINATE/POLY(ETHYLENE OXIDE) NANOFIBERS FOR WOUND HEALING APPLICATIONS: CHALLENGES AND FUTURE DIRECTIONS
Authors:   ", AL-MOALEMI HAFEDH AHMED ,   Department of Bioscience, Faculty of Science, Universiti Teknologi Malaysia, 81310,  Skudai, Johor, Malaysia ", IZWAN ABD RAZAK SAIFUL ,   School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, 81300, Skudai, Johor, Malaysia, BOHARI SITI PAULIENA MOHD ,   "Department of Bioscience, Faculty of Science, Universiti Teknologi Malaysia, 81310,  Skudai, Johor, Malaysia "
Published: May 2022

Alginate is an interesting natural biopolymer to be considered for biomedical applications due to its advantages and good biological properties. These biological properties make electrospun alginate nanofibers suitable for various uses in the biomedical field, such as wound healing dressings, drug delivery systems, or both. Unfortunately, the fabrication of alginate nanofibers by electrospinning is very challenging because of the high viscosity of the solution, high surface tension and rigidity in water due to hydrogen bonding, and also their diaxial linkages. This review presents an overview of the factors affecting the electrospinning process of sodium alginate/poly(ethylene oxide) (SA/PEO), the application of SA/PEO in drug delivery systems for wound healing applications, and the degradation and swelling properties of SA/PEO. The challenges and future directions of SA/PEO in the medical field are also discussed.
"FORMATION OF HYDROGELS FROM ANTIOXIDATIVE SYNTHETIC HYDROXYCINNAMATE ESTER CONJUGATES BASED ON CORN BRAN ARABINOXYLAN "
Authors:   ", LI YANLI ,   College of Chemistry and Engineering, Sichuan University of Science and Engineering, 519, Huixing Road, Ziliujing District, Zigong 643000, China"
Published: May 2022

Corn bran arabinoxylan (CAX) was extracted from corn bran and modified through conjugating to four hydroxycinnamic acids (HAs), namely ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), and sinapic acid (SA). These HA arabinoxylan esters (HA-CAX-n) exhibited analogous n-degrees of substitution (DS), FA-CAX-0.31, p-CA-CAX-0.32, CA-CAX-0.32, and SA-CAX-0.31. The antioxidant capacity was evaluated by a chemical method – an oxygen radical antioxidant capacity (ORAC) assay – and cellular models – a cellular antioxidant activity (CAA) assay to healthy human skin fibroblasts (HSF). The results of the various analyses were comparable, demonstrating the order of antioxidant capability was: CA-CAX-0.32 > SA-CAX-0.31 > FA-CAX-0.31 > p-CA-CAX-0.32. HA-CAX-n gels with different crosslinking ability were obtained with the concentration of 0.5% (w/v) during oxidative gelation by laccase, SA-CAX-0.31 can form gels most easily, followed by FA-CAX-0.31, CA-CAX-0.32 and p-CA-CAX-0.32.
"CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PISTACIA VERA L. LEAVES: BENEFICIAL EFFECTS OF FEMALE LEAVES EXTRACT ON FOOD PRODUCTS "
Authors:   ", ELAKREMI MANEL ,   Organic Chemistry Laboratory (LR17ES08), Faculty of Sciences of Sfax, University of Sfax, Sfax 3029, Tunisia ", SILLERO LEYRE ,   "Department of Chemical and Environmental Engineering, Biorefinery Processes Research Group, University of Basque Country (UPV/EHU), Donostia-San Sebastian, Spain ", AYED LAZHER ,   "Laboratory of Applied Fluids Mechanics and Modeling, National School of Engineers of Sfax, University of Sfax, Sfax 3029, Tunisia ", MANNAI FATEN ,   "Laboratory for Application of Materials to the Environment, Water and Energy (LR21ES15), Faculty of Sciences of Gafsa, University of Gafsa, Tunisia ", BEN SALEM RIDHA ,   "Organic Chemistry Laboratory (LR17ES08), Faculty of Sciences of Sfax, University of Sfax, Sfax 3029, Tunisia ", LABIDI JALEL ,   "Department of Chemical and Environmental Engineering, Biorefinery Processes Research Group, University of Basque Country (UPV/EHU), Donostia-San Sebastian, Spain ", MOUSSAOUI YOUNES ,   "Organic Chemistry Laboratory (LR17ES08), Faculty of Sciences of Sfax, University of Sfax, Sfax 3029, Tunisia "
Published: May 2022

The aim of this work was to analyze the chemical composition of two types of leaves (female and male) of Pistacia vera L. and estimate their potential use in the bread industry. With that purpose, the total phenolic and flavonoid contents and the biological activities of their extracts were investigated. The extracts expressed high values of phytochemicals, as well as antioxidant and antimicrobial activities. The extract of female plant leaves, having shown the best results, was chosen to fortify flour bread. The fortified bread showed improvement in phytochemicals content and biological activities. The total phenolic content of bread samples varied from 0.09 to 7.96 mg gallic acid equivalent (GAE)/g bread, and the total flavonoid content varied from 0.06 to 5.78 mg catechin equivalent (CE)/g bread. The antioxidant activity of bread was in the range of 0.04-11.08 mg trolox equivalent (TE)/g bread, using DPPH tests. Thus, it was concluded that the extract of Pistacia vera L. female plant leaves could be added to baking formulations to improve bread properties and prolong its shelf life.
"A NEW PEACH PALM FIBER MAT FOR POLYURETHANE MATRIX COMPOSITES: BEHAVIOR TO UV-ACCELERATED WEATHERING "
Authors:   ", ZAMBONATO FARINA MARINA ,   Programa de Pós-Graduação em Engenharia de Processos, Universidade de Joinville  (Univille), 89219-710 Joinville, Brasil ", BATISTA MANCINELLI KETLIN CRISTINE ,   "Programa de Pós-Graduação em Saúde e Meio Ambiente, Universidade de Joinville,  89219-710 Joinville, Brasil ", TESTA PEZZIN ANA PAULA ,   "Programa de Pós-Graduação em Engenharia de Processos, Universidade de Joinville  (Univille), 89219-710 Joinville, Brasil ", ABATTI KASPER SILVA DENISE ,   "Programa de Pós-Graduação em Engenharia de Processos, Universidade de Joinville  (Univille), 89219-710 Joinville, Brasil "
Published: May 2022

Fibers from agricultural residues originating from harvesting heart-of-palm, a renewable resource, have been explored to produce composites with low cost and sustainability, from widely available raw materials. This work investigated the influence of fiber mat percentage and UV-accelerated aging on the properties of polyurethane (PU) matrix composites. The highlight is on the dissociation process of extracting the fibrils from peach palm leaves and producing a fiber mat. The hemicelluloses, cellulose, and lignin contents were determined before and after the dissociation. The mats were incorporated into the matrix by the hand lay-up method corresponding to 6 or 10 wt%. The composites were subjected to accelerated weathering for 90 days and then were characterized by TGA, SEM and tensile testing. The main results indicated that the thermal stability of the composites remained similar to that of neat PU, and the UV-weathering effect on mechanical properties was evident after 90 days of exposure.
A Guide to Selecting Participatory Research Methods Based on Project and Partnership Goals
Authors: Duea Stephanie R. , Zimmerman Emily B. , Vaughn Lisa M. , Dias Sónia , Harris Janet
Published: May 2022

Participatory research engages community stakeholders in the research process, from problem identification and developing the research question, to dissemination of results. There is increasing recognition in the field of health research that community-engaged methods can be used throughout the research process. The volume of guidance for engaging communities and conducting participatory research has grown steadily in the past 40+ years, in many countries and contexts. Further, some institutions now require stakeholder engagement in research as a condition of funding. Interest in collaborating in the research process is also growing among patients and the public. This article provides an overview for selecting participatory research methods based on project and partnerships goals.
Peran Guru dalam Meningkatkan Minat Belajar Siswa di Kelas III SD Negeri 182/I Hutan Lindung Muara Bulian
Authors: Sobari Ahmad , Bastian Oktavioni , Listiana Listiana , Syahrial Syahrial , Noviyanti Silvina
Published: May 2022

The purpose of this study was to determine the teacher's role as a motivator in increasing the learning interest of third grade students at SD Negeri 182/I Hutan Lindung. This study uses a descriptive method with a qualitative approach. Data collection techniques carried out in this study were by means of observation, interviews and documentation. Based on the results of the study, there are ten ways that teachers do in carrying out their role as motivators. However, from the results of the research described above, there are only eight ways teachers can carry out their role as motivators. The eight ways are: using varied methods, creating competition, giving evaluations or tests, giving grades or numbers, notifying learning outcomes, giving prizes, giving praise, and giving punishment. Meanwhile, two ways that were not seen during the study were helping learning difficulties and forming good habits. Based on the results of the study, it can be concluded that the teacher's role as a motivator in increasing student interest in class III at SD Negeri 182/I Hutan Lindung, is 1) Using various methods, 2) Creating competition / competition, 3) Giving evaluation / test, 4 ) Giving grades or numbers, 5) Informing students' learning outcomes, 6) Giving gifts to students, 7) Giving praise, 8) Giving punishment if they don't do assignments.
EMG-based Simultaneous Estimations of Joint Angle and Torque during Hand Interactions with Environments
Authors: Kim Dongwon , Koh Kyung , Oppizzi Giovanni , Baghi Raziyeh , Lo Li-Chuan , Zhang Chunyang , Zhang Li-Qun
Published: May 2022

It is necessary to control contact force through modulation
of joint stiffness in addition to the position of our limb when manipulating an
object. This is achieved by contracting the agonist muscles in an appropriate
magnitude, as well as, balancing it with contraction of the antagonist muscles.
Here we develop a decoding technique that estimates both the position and
torque of a joint of the limb in interaction with an environment based on
activities of the agonist-antagonistic muscle pairs using electromyography in
real time. The long short-term memory (LSTM) network that is capable of
learning time series of a long-time span with varying time lags is employed as
the core processor of the proposed technique. We tested both the unidirectional
LSTM network and bidirectional LSTM network. A validation was conducted on the
wrist joint moving along a given trajectory under resistance generated by a
robot. The decoding approach provided an agreement of greater than 93% in
kinetics (i.e. torque) estimation and an agreement of greater than 83% in
kinematics (i.e. angle) estimation, between the actual and estimated variables,
during interactions with an environment. We found no significant differences in
performance between the unidirectional LSTM and bidirectional LSTM as the learning device of the proposed decoding
method.
Formulation and Evaluation of Mango Leaf Tea Supplemented with Moringa and Ginger Powder
Authors: AB Yusuf , AA Turaki , AA Adetunji
Published: May 2022

Herbal teas contain bioactive compounds which have been reported to have beneficial effects in the prevention of various metabolic diseases. Hence, the current study was conducted to assess the qualitative and quantitative phytochemical composition, functional properties and sensorial attributes of different formulations of mango leaf teas supplemented with Moringa oleifera and ginger powder as supporting and activating herbs using standard analytical methods of Association of Official Analytical Chemist. Data was analyzed using one way analysis of variance and results expressed as mean ±standard deviation of triplicate determinations. The qualitative phytochemical analysis indicated the presence of tannins, flavonoids, terpenoids and cardiac glycoside. While quantitative analysis revealed that flavonoids ranged from (0.17-0.52 mg/g), tannins (0.07-0.11 mg/g), cardiac glycoside (1.08-1.89 mg/g) and terpenoids (50%-70%). The results obtained for functional properties revealed that pH ranged from (5.94-6.62), reconstitution index (4-6.6 g/cm3), swelling index (0.33-1.33cm3/g), wettability (3.08-3.14 mins), bulk density (0.25-0.29 g/cm3) and water absorption capacity (27.3-31.9). Mean scores of sensory evaluations for taste ranged from: (7.2-8.9), color (7.6-8.5), flavor (7.3-8.3), consistency (7.3-8.4) and overall acceptability (7.9-8.7). Based on the results of this study, it can be concluded that mango leaf teas supplemented with Moringa oleifera and ginger powder are good sources of bioactive compounds with potential nutritional and health benefits.
Integrating building and context information for automated zoning code checking: a review
Authors: İlal M. Emre , İlal M. Emre
Published: May 2022

Interoperability approaches have attracted much attention in the AEC/FM industry with the increased interest in Building Information Modeling (BIM) studies since 2000’s. Especially, the integration of BIM with GIS is crucial for areas, which need detailed information on buildings and their surroundings. Automated code compliance checking against zoning codes is an area that requires both zoning data and building design data. In an ideal automated zoning code checking process, building codes should be retrieved from the responsible authority, data regarding the neighborhood the project is located in should be retrieved directly from the local municipality’s GIS, and the building project should be supplied by the designer as a BIM file. The checking process should be able to work with a combination of GIS and BIM data and generate a compliance report. Although recent BIM-GIS integration efforts have been successful in some areas, BIM-GIS integration studies in the context of automated zoning code compliance checking are limited, and the data interoperability problem in this field still needs to be addressed. This paper intends to (1) provide a critical review and analysis of the current BIM and GIS integration studies for building permit processes, (2) present the opportunities that the implementation of integrating BIM and GIS might bring to the automated zoning compliance checking domain and (3) identify promising integration approaches for future efforts.
Analisis Variasi Genetik I/D Gen Angiotensin Converting Enzyme (ACE) Dengan Daya Tahan Otot Pada Atlit Sulawesi Selatan Bangkit (SSB)
Authors: Hadi Indriono
Published: May 2022

Analisis Variasi Genetik I/D Gen Angiotensin Converting Enzyme (ACE) Dengan Daya Tahan Otot Pada Atlit Sulawesi Selatan Bangkit (SSB).
Pengaruh Subtitusi Tepung Ikan Teri Terhadap Mutu Biskuit
Authors: Fatmawati Fatmawati
Published: May 2022

Pengaruh Subtitusi Tepung Ikan Teri Terhadap Mutu Biskuit.
Hubungan Pekerjaan Dan Pendidikan Ibu Dengan Pemberian Air Susu Ibu Pada Bayi Di Wilayah Kerja Puskesmas Kota Kendari
Authors: Leksono Purnomo
Published: May 2022

Hubungan Pekerjaan Dan Pendidikan Ibu Dengan Pemberian Air Susu Ibu Pada Bayi Di Wilayah Kerja Puskesmas Kota Kendari.
Hubungan Pendapatan Keluarga, Kebiasaan Makan Dan Pengeluaran Pangan Dengan Status Gizi Anak Balita Di Kelurahan Talia Kecamatan Abeli Kota Kendari, 2008
Authors: Toruntju Sultan Akbar
Published: May 2022

Hubungan Pendapatan Keluarga, Kebiasaan Makan Dan Pengeluaran Pangan Dengan Status Gizi Anak Balita Di Kelurahan Talia Kecamatan Abeli Kota Kendari, 2008.
Studi Epidemiologi Penyakit Filariasis Di Kabupaten Muna Tahun 2006-2007
Authors: Banudi La
Published: May 2022

Studi Epidemiologi Penyakit Filariasis Di Kabupaten Muna Tahun 2006-2007.
Hubungan Pengetahuan Dan Sikap Ibu Tentang Perawatan Perianal Dengan Kejadian Diaper Dermatitis Pada Anak Di Tempat Penitipan Anak (TPA) Dharma Wanita Persatuan UNHAS Makassar
Authors: Sahmad Sahmad
Published: May 2022

Hubungan Pengetahuan Dan Sikap Ibu Tentang Perawatan Perianal Dengan Kejadian Diaper Dermatitis Pada Anak Di Tempat Penitipan Anak (TPA) Dharma Wanita Persatuan UNHAS Makassar.
Pengaruh Perilaku SADARI (Pemeriksaan Payudara Sendiri) Terhadap Deteksi Dini Kanker Payudara Pada Mahasiswa Jurusan Kebidanan Tingkat II Politeknik Kesehatan Kendari
Authors: Halijah Halijah
Published: May 2022

Pengaruh Perilaku SADARI (Pemeriksaan Payudara Sendiri) Terhadap Deteksi Dini Kanker Payudara Pada Mahasiswa Jurusan Kebidanan Tingkat II Politeknik Kesehatan Kendari.
Hubungan Pengetahuan, Sikap, Dan Tindakan Pemberian ASI Dengan Status Gizi Anak 102 Tahun Di Puskesmas Tongauna Kabupaten Konawe Tahun 2011
Authors: Toruntju Sultan Akbar
Published: May 2022

Hubungan Pengetahuan, Sikap, Dan Tindakan Pemberian ASI Dengan Status Gizi Anak 102 Tahun Di Puskesmas Tongauna Kabupaten Konawe Tahun 2011.
Faktor-Faktor Yang Berhubungan Dengan Pemberian ASI Eksklusif Oleh Ibu Bayi
Authors: Toruntju Sultan Akbar
Published: May 2022

Faktor-Faktor Yang Berhubungan Dengan Pemberian ASI Eksklusif Oleh Ibu Bayi.
Optimized identification of microorganisms directly from positive blood cultures by MALDI-TOF to improve antimicrobial treatment
Authors: García Clemente Paloma , Romero-Gómez María Pilar , García-Rodríguez Julio , Cendejas-Bueno Emilio
Published: May 2022

Introduction. Bacteriemia is a major cause of morbidity and mortality among hospitalized patients worldwide. Early identification of microorganisms from blood culture can lead to improvement of treatment and outcomes. Methods. The study was divided into two phases. The first phase when a comparison of the methods was made to check the concordance between them, using as a reference the standard method implemented in the laboratory. In a second phase, both methods are combined. We used the rapid identification method and when it could not identify we used the standard method. The microorganisms that were not identified by either of the two methods were identified from colony at 24 hours Results. A total of 589 microbial positive blood cultures have been included in the present study. With the rapid method we obtained 96% and 88% identification results for Gram-negative bacilli (GNB) and Gram-positive cocci (GPC) respectively. In this study we observed that the combination of the rapid and standard method achieved identifications of 98% and 97% for GNB and GPC respectively. Conclusions. The data analysed shows that both methods combined perform better than individually. We achieved an optimization of the identification of microorganisms directly from positive blood cultures by MALDI-TOF. This combination identified 98% of the microorganisms in between ten minutes to one hour and a half since the blood culture flagged positive.
TRYPTOPHAN METABOLITES-MEDIATORS OF THE «MICROBIOM OF INTENSTINE – ADIPOSE TISSUE» AXIS
Authors: Shestopalov A. V. , Shatova O. P. , Gaponov A. M. , Volkova N. I. , Rumyantsev A. G. , Moskaleva N. E. , Appolonova S. A. , Makarov V. V. , Yudin S. M. , Rumyantsev S. A.
Published: May 2022

In the last 10 years, there has been an active study of the system of coupling the metabolism of a macroorgan- ism and its microbiome. The microbiotic conversion of food substrates into small biologically active signaling mol- ecules represents a potential regulatory mechanism by which the gut microbiota can alter the physiology of gut cells and the entire macroorganism. It was found that in patients with obesity, but without metabolic disorders, the level of serum tryptamine was statistically significantly higher than in patients with metabolically unhealthy obesity. For obesity, regardless of the presence/absence of metabolic disorders, it was found that xanthurenic and quinolic acids stimulate the secretion of myostatin. At the same time, for patients with metabolically healthy obesity, the leading role of indole-3-acetate in the coordinated stimulation of insulin and leptin secretion is shown. Whereas in patients with metabolically unhealthy obesity, anthranilic acid stimulates leptin secretion. For insulin, the decrease in secretion is provided by indole-3-propionate in patients with metabolically unhealthy obesity. In addition, indole-3-propionate and tryptamine activate the secretion of FGF 21 in patients with metabolically unhealthy obesity. From the data obtained, it can be assumed that changes in the concentrations of various tryptophan metabolites have a relationship with the level of adipokine/myokine secretion and, consequently, with the development of metabolically healthy or metabolically unhealthy obesity.
SKIN: MORPHOLOGY, HISTOCHEMISTRY, HISTOPHYSIOLOGY
Authors: Tcibulevsky G. Y. , Dubovaya T. К.
Published: May 2022

The article presents lecture material on the study of the morphofunctional characteristics of the skin and its deriva- tives, included in the modern spectrum of active and interactive forms of teaching histology in order to effectively form the professional competence of future doctors of the specialties «General Medicine», «Pediatrics» and «Dentistry», as well as students of biological faculties.
EXISTING AND POTENTIAL POSSIBILITIES OF SALIVARY DIAGNOSTICS IN BREAST CANCER
Authors: Shatokhina A. S. , Bykov I. M. , Filippov E. F. , Kurzanov A. N.
Published: May 2022

Currently used methods of laboratory diagnostics of breast cancer (BC) and related diagnostic procedures are not perfect. Nowadays, there exists a restricted amount of information proving the application of salivary biomarkers as diagnostic instruments for BC. This review presents the research results in the field of salivary diagnostics in BC. The most well studied biomarkers of BC in mixed saliva are: epidermal growth factor, caner antigen 15-3, epidermal growth factor receptor HER2/neu. Some publications suggest that it is appropriate to use saliva as an alternative to blood to detect gene mutations in BRCA1/2 when searching for hereditary forms of BC. It was shown that determination of salivary peroxidase, advanced glycation end products, total antioxidant status and malone dialdegid can be of signifi- cant importance in non-invasive diagnostics of BC. As a further possibility for early diagnosis of BC, it is considered to use profile analysis of free amino acids in saliva, transcriptomic biomarkers - mRNA CSTA, TPT1, IGF2BP1, GRM1, GRIK1, H6PD, MDM4, S100A8 and proteomicо biomarker - carboanhydrase VI, polyamines as well as a number of metabolic proteins. It is assumed that analysis of saliva can become as useful in laboratory diagnostics of BC as analy sis of blood biomarkers. Moreover, research and description of constellations of analyzed blood and saliva biochemical and genetic values in BC are not only of a scientific interest, but are also of practical utility in order to improve laboratory diagnostics methods for this disease. Relationship between biochemical and genetic factors of saliva and blood, as well as the future use of their most informative constellations for early diagnosis of BC becomes currently a subject of detailed scientific research, which is proved by the facts provided in this review.
GENOMIC SCIENCE-BASED PERSONALIZED TREATMENT FOR CANCER
Authors: Varghese Jeffy Vianneys , Sorokina L. E. , Rebik A. A. , Regan O. V.
Published: May 2022

At present, cancer is a rising dreadful issue all around the world, as it is among one of the main leading causes for mortality globally. Recent improvements in genetic engineering called genome sequencing provides a different ap- proach in the treatment of cancer. Genome sequencing is a technique used for determining the complete composition of the DNA sequence of a genome. The cancer genomic project and the cancer genome atlas are initiatives taken by different countries to analyze and store the genomic sequence variations of different tumor cells from a diverse popula- tion. Sequencing malignant cells have pointed the unique abnormalities like mutations in the genes, which shows the exact cause for the uncontrolled cell division in many types of malignancies. We discuss the recent effective method called next-generation sequencing which has the ability to sequence DNA molecules in thousands, simultaneously, rapidly, and cost- effectively. NGS can detect all types of mutations and chromosomal abnormalities. This information provides a detailed and improved understanding of different types and subtypes of cancer from their molecular basis. The process includes sequencing of both tumor and normal genome from the same individual, and then are examined and verified. This data is used to provide a personalized treatment routine for that specific patient which can improve their prognosis. The various challenges and limitations of NGS which are hindering the advancement and the prob- ability of using it in clinical oncology are also discussed which include ethical problems and abundant data generated causing an issue in data analysis. We outline the recent promising developments in implementing genomic science in the personal and targeted treatment of cancer for better prognosis and plausible cure for malignancy in the near future.
FEATURES OF THE ELEMENT STATUS OF EARLY AGE CHILDREN WITH MENTAL AND PHYSICAL RETARDATION
Authors: Evstafeva E. V. , Zalata O. A. , Slusarenko A. E.
Published: May 2022

The aim of the research was a determination of the element’s status features in children 1-3th age with mental and physical retardation. In 36th children from 1-3th age with mental and physical retardation the content of (Ca, Cu, Fe, K, Zn, Mn, S, Br, Se, Co, Cr, Cl, Ni, Mo, Sr, As, Hg, Pb) in hair was determined by a method of X-ray fluorescent spectroscopy. Hair chemical elements content was determined in1-3-year-oldchildren with mental and physical de- velopmental delay suggesting some specificchanges of elemental status. It is established that the examined children had the excess of potassium, chlorine, nickel, chromium, manganese, calcium, on the background of total deficit of zinc, copper, partially of iron and normal content of toxic elements. Excess of potassium, chlorine, nickel, chromium, manganese, calcium in accordance with this research and literature data may be a specific feature of element status at nervous disorders. However, individual assessment of the «element portrait» at diseases of the nervous system in children of early age is important to improve a treatment and rehabilitation. Comparison of the revealed features with previously collected data of healthy children and literature indicates that zinc and copper deficiency is not specific for the children with mental and physical developmental delay but is rather more significant.
CONCENTRATIONS OF SEVERAL CYTOKINES IN BLOOD SERUM IN WOMEN WITH AUTOIMMUNE THYROIDITIS
Authors: Ignatenko T. S. , Maylyan E. A. , Kapanadze G. D.
Published: May 2022

147 women aged 31-47 years with autoimmune thyroiditis were examined. The control group included 63 appar- ently healthy women of the same age without thyroid disease. Using enzyme-linked immunosorbent assay, serum levels of tumor necrosis factor α (TNF-α), interleukins (IL) -1β, -6, -8, -17A, receptor activator of nuclear factor-kappa β ligand (RANKL) and osteoprotegerin (OPG) were determined. The median, interquartile range and Spearman’s rank correlation coefficient were calculated. The Mann-Whitney test was used to compare two independent samples.

Autoimmune damage of the thyroid gland was characterized by a significant (p<0,001) increase in the levels of IL-1β and IL-6 against the background of a trend towards an increase of serum IL-17A concentration (p=0,067). At the same time, the values of TNF-α and IL-8 did not differ significantly from those of women in the control group (p=0,166 and p=0,102, respectively). Also, autoimmune thyroiditis in women was accompanied by a significant increase of RANKL concentration (p=0.029), while the OPG content remained at control levels (p=0,988). A regular decrease in the OPG/RANKL ratio was also recorded (p=0,017). The presence of a significant (p<0,05) positive relationship of IL-6 concentrations with TNF-α, IL-8, IL-17A and RANKL values, as well as between RANKL and IL-8 values was established. In addition, the concentration of RANKL was characterized by a direct correlation with the content of the anti-inflammatory mediator OPG. Attention is drawn to the revealed negative correlation between the OPG/RANKL index and IL-6 values.
Autoimmune thyroiditis in women is characterized by a significant increase of serum levels of IL-1β, IL-6, RANKL and a decrease in the OPG/RANKL index, while the indices of IL-8, TNF-α and OPG production do not change signifi- cantly. For IL-6 concentrations, a positive correlation was established with the values of TNF-α, IL-8, IL-17 and nega- tive - with the OPG/RANKL ratio. RANKL values have a direct relationship with IL-6, IL-8 and OPG levels.
FUNCTIONAL FEATURES OF CHEWING MUSCLE IN CHILDREN WITH PHYSIOLOGICAL OCCLUSION
Authors: Kosolapova I. V. , Dorokhov E. V. , Kovalenko M. E.
Published: May 2022

The influence of sexual dimorphism on the functional features of chewing muscles in children may become a prerequisite for differences in the timing and methods of examining the functional state of chewing muscles, to various options for choosing techniques and preventing dentate abnormalities. Materials and methods. During the work study, 38 children aged 6 to 12 years with a physiological occlusion were examined. Evaluation of the bioelectric activity of temporal and sublingual muscles was carried out using superficial electromyography, the Chewing General sample, and the evaluation of the tone of the chewing muscles proper was carried out using the Mioton-3C device. Results. When comparing the tone of the chewing muscles and gender, it was not possible to establish statistically significant differences. When assessing all indicators of bioelectric conductivity of temporal and sublingual muscles of boys and girls, it was not possible to establish statistically significant differences. Conclusions. No relationship was identified between sexual dimorphism and functional features of chewing muscle in children with physiological occlusion at a given sample size. This may indicate the possibility of using the same choice of technique and prevention of tooth anomalies in boys and girls of this age group
EPIDEMIOLOGICAL TRENDS OF CARDIOESOPHAGEAL GASTRIC CANCER AND ESOPHAGOS CANCER IN THE REPUBLIC OF KHAKASIA
Authors: Shtygasheva O. V. , Ageeva E. S.
Published: May 2022

Aim to analysis of the epidemiological characteristics of gastric cancer of proximal localization and esophagus cancer in the population of the Republic of Khakassia. Materials and methods. We studied 142 cases of esophagus cancer and 684 cases of gastric cancer, including 74 incidents of proximal localization by the continuous method for 2015-2019 (100%). In all cases, the diagnosis was established according to ICD 10 revision, TNM (2009) and verified morphologically. The study of the clinical debut of malignant tumors was carried out by comparing the general popula- tions of patients with esophagus cancer and gastric cancer of proximal localization over a 5-year period, dividing for 10-year-period groups. Results. There is an increase in the incidence rate of cancer of the esophagus by 1.4 times, gastric cancer by 1.1 times, and the share of cardioesophageal cancer of the stomach to 17.6%. Squamous cell car- cinoma dominates in the morphological structure in case of cancer of the esophagus (86, 6%), and adenocarcinoma (96.2%) in case of gastric cancer. Men have 1.26 times more often with gastric cancer of all localizations than women,
1.64 times more with cardioesophageal cancer of the stomach, 4.9 times more in patients with cancer of the esopha- gus, consistently. An exception are tumors of the bottom of the stomach (men are 0.75 times less than women). In cancer of the esophagus, the most frequent manifestation age is 60-69 years (42.9%). With cardioesophageal cancer of the stomach, every second patient is over 70 years old. Conclusion. The incidence of cardioesophageal cancer of the stomach and cancer of the esophagus is increasing.
VINNITSKY ILYA MARKOVICH
Authors: Ageeva E. S. , Demidenko L. A.
Published: May 2022

The article is devoted to the activities of an outstanding person - scientist, helminthologist, geneticist, Doctor of Biology Sciences, Professor I.M.Vinnitsky (1910-1951). Ilya Markovich was the head of several biological departments of medical institutes in the Soviet Union (Simferopol, Tomsk, Sverdlovsk, Samarkand). His life was extraordinary, bright and at the same time difficult.

Despite the fact that the period of his labor activity at that time fell on the era of the organization and formation of many medical institutes, his scientific, pedagogical and organizational activities left important, necessary traces for fu- ture generations of doctors in our country. Nevertheless, the archives and departments, as it turned out, do not contain rich information even about the great and significant people of that period. Perhaps this is due to wartime, when only in Simferopol the Crimean Medical Institute experienced 2 evacuations and countless bombings.
Ilya Markovich’s family members, son Vladimir Ilyich and grandson Danil Vladimirovich, helped the authors to restore the lost parts of the biography, but in essence they were told on the basis of the surviving part of the copies of documents, so that we know and remember, and could pass on to future generations about our teachers and inspirers. The article is part of a series of publications of the Department of Medical Biology, dedicated to the 90th anniver- sary of the Medical Academy named after S.I. Georgievsky and the 90th anniversary of the Department of Medical Biology, the anniversary of which fell on 2021.
RESEARCH OF MODERN TRENDS IN THE DEVELOPMENT OF THE SERVICE SECTOR ON THE EXAMPLE OF THE E-COMMERCE MARKET
Authors: Myavlina N. Zh. , Tsopa N.V.
Published: May 2022

The article discusses the main trends in the development of the service sector, using the example of the e-commerce market in Russia, identifies the features of this market, shows the main players in this market, identifies the differences between buyers of this market, changes in their requirements for the presentation of products and their assortment, customer preferences, analyzed the results of development in recent years, and presented the prospects for the development of online Commerce.
TERRITORIAL ORGANIZATION OF THE OBSERVATION NETWORK OF ATMOSPHERIC AIR POLLUTION MONITORING IN THE CITY OF SEVASTOPOL
Authors: Gutnik V.S. , Azarenko E.I. , Gutnik S.A. , Sigora G.A. , Nichkova L.A. , Khomenko T.Yu.
Published: May 2022

The article provides justification for the choice of the number and location of stationary and route posts for monitoring atmospheric air pollution, taking into account the density of the location of emission sources and residential buildings in the city of Sevastopol, areas with the highest multiplicity of exceeding the MPC of atmospheric air in populated areas, determined on the basis of constructing a concentration distribution matrix pollutants. Maps of the location of stationary, local route and highway route observation posts were compiled. The characteristic of the projected observation network is given with the rationale for the choice of periods for monitoring the level of atmospheric air pollution.
FEATURES OF ENGINEERING AND ENVIRONMENTAL MEASURES IN THE ALMA RIVERBED
Authors: Ivanenko T.A. , Komissarenko E.
Published: May 2022

The current situation with the formation of water scarcity in most of the territory of the Crimean peninsula determines the development and implementation of measures to maintain the quality and required volume of surface runoff of rivers. Of great relevance and social significance is the implementation of measures for clearing and channel regulation of the rivers of the Republic of Crimea, preventing the negative impact of water and eliminating their consequences in relation to water bodies completely located on the territory of the Republic of Crimea. The implementation of measures will lead to the stabilization of the water management situation.
RESEARCH OF THE MAIN APPROACHES TO THE MANAGEMENT OF INVESTMENT PROJECTS FOR THE CONSTRUCTION OF SOCIAL FACILITIES
Authors: Tsopa N.V. , Khalilov A.E.
Published: May 2022

This article examines the main approaches to the interpretation of the term project, project for the construction of a social facility, project management. The article analyzes three approaches to project management: traditional, subject, process. The features of the implementation of three approaches to project management in relation to social objects are revealed. In addition, significant attention is paid to the mechanism for applying the ISO 21500 standard in the management of projects for the construction of social facilities. An improved block diagram of work with design estimates and the development of a project for the production of work at the preparatory stage for the construction of a social facility is proposed.
Teacher Absenteeism and Curriculum Implementation in Primary Schools in Nyamagana District in the Mwanza Region of Tanzania
Authors: Mgema Boma
Published: May 2022

This study sought to explore teacher absenteeism and its impact on curriculum implementation in primary schools in Nyamagana District. The study employed a quantitative research approach and cross-sectional survey design. A sample of 3 head teachers, 1 Teachers Service Commission Officer, 30 teachers, and 56 pupils were involved in the study. A questionnaire was employed as a method of data collection with a Cronbach alpha coefficient of correction of 0.733, meaning that it was reliable. Descriptive statistics basically frequency and percentages, were used to analyse data with the aid of SPSS. The study found that teacher absenteeism is less experienced in the visited schools. The findings revealed that poor coverage of syllabi and indiscipline among pupils are some of the effects of teacher absenteeism which indicate that the tragedy accelerates poor curriculum implementation. Thus, the study recommends a suitable legal framework and incentives to improve teachers’ welfare and hence limit teacher absenteeism.
AFFIRMATION OF SELF-EXISTENCE IN “LADY OF SCANDAL’’ BY TINA GABRIELL
Authors: Arianto Tomi , Bere Noviana Osinta
Published: May 2022

This study aimed to analyse the affirmation of self-existence against patriarchal construction in the novel "Lady of Scandal" by Tina Gabrielle. This research used feminist approach Simone de Beauvoir (2016) in her theory women existence. This study focused on four factors that caused women against patriarchy, namely submissive, matchmaking, mala fide and domesticity. To analyse kinds of affirmation against patriarchal construction, researcher focused on the Beauvoir terminology related; the intellectual, being herself, and freedom to actualize self. This research used qualitative methods. In this study, the researcher found on two points that made woman against patriarchy. First, because women have seen as second sex who were oppressed by men based the values and norms by society who believed in patriarchal culture. Second, woman awareness against patriarchy reflected from the showing of her existences as a woman
AMERICAN SOCIAL CLASS DISSIMILARITY AS REFLECTED IN MICHAEL GRACEY’S MOVIE “THE GREATEST SHOWMAN”
Authors: Wahana Balqis Majesty , Johan Mhd
Published: May 2022

This study aimed investigate about American social class dissimilarity as reflected in Michel Gracey’ movie entitled The Greatest Showman, to reveal the causes in social class dissimilarity in America , to describe the impacts of American Social Class to the main character and the society and to find solution to solve tis social problem as reflected in the film. The objectives of this research were looking the problems that found in Michael Gracey’ film entitled The Greatest Showman. The data were taken from the narration of this movie which are relevant to discussion of the study. The data were collected by watching the movie and reading the movie script in several times, selecting data, discussion from  identifying date to report in paper to discribe the condition. The qualitative method used in this research by developing ideas and analyzing the data based on librarian research.  The results of this analyzing are people underestimate others and the impact American social class in society of relationship.
TELAAH PEMBELAJARAN MAHASISWA TERHADAP PERAN BAHASA INDONESIA DI PERGURUAN TINGGI
Authors: Barimbing Suryani , Oktavia Yunisa
Published: May 2022

The Indonesian language course is one of the general subjects that must be taught at the tertiary level, either at the Diploma or Bachelor level. This rule of course has been stated in Article 35 paragraph 3 of Law number 12 of 2002 which is related to learning in higher education. Based on the article, the Indonesian language courses at the university level have changed their names, namely to become general compulsory subjects (MKWU) which were originally called the General Basic Courses (MKDU). It can be said that a substance in the study of Indonesian general courses will always focus on an emphasis on skills in the use of Indonesian as a language known as the national language. However, in accordance with the existing truth, in doing academic writing which is an effort that can be made in obtaining a national literacy program as has happened at this time which is really not in accordance with the intended expectations. Of course, in reality this will have an impact on students at the high school level who will enter the university level who will of course study Indonesian language courses. Seeing in the problems that will arise in the learning process, of course, it is very necessary, namely learning model that will begin to lead to how the ability of the student in carrying out recovery from an event that is in learning. Of course, the learning model as proposed is a guide from various sources by referring to the main points of a problem that will be faced, of course, by lecturers of the Indonesian General Course.
DIRECTIVE ILLOCUTIONARY ACTS OF JAMES CORDEN’S UTTERANCES “THE HOST”
Authors: Sembiring Wulan Angelia , Ambalegin Ambalegin
Published: May 2022

This descriptive qualitative research explored one of speech acts phenomena. The researchers took directive acts types as the object of this research. Utterances of directive acts that the host produced were used as the data source. The directive acts types were analyzed by employing Searle and Vanderveken (1985)’s theory regarding types of directive acts. Observational method was adopted to analyze data and it also used non-participatory technique collection. The data were analyzed through pragmatic identity method and competence in equalizing technique by Sudaryanto (2015). It discovered that there had 18 utterances of directive acts in James Corden’s utterances. There were eight of command, six of request, prohibition and question had two data. The type of permission was not uttered by the host and guests. The dominant type was command because the host was the host, which means he owned higher degree compared to the guests.
THE USE OF CODE MIXING IN SUMITOMO COMPANY: SOCIOLINGUISTICS APPROACH
Authors: Haloho Nila Sari , Johan Mhd. Johan
Published: May 2022

The goal of this study was to discover the different code mixing types and the reasons why the leader spoke code mixing during in the meeting with employees. On Monday, he presided over the meeting, which included some code mixing. In  this research, the writer used a qualitative descriptive method. The data were taken by recording the utterance of the leader then observed the words that referred to code mixing and the reason of choosing to use code mixing. They are found three types of code mixing the first  intra-sentential code mixing, the second intra- lexical form and the last is the  pronunciation changing.
The effect of an educational curriculum using shadow boxing exercises to learning perform the straight punch of boxing for students
Authors: Ahmed Asst. Prof. Dr. Samer Abdulhadi
Published: May 2022

The importance of the research lies in the use of shadow boxing exercises to learning perform the straight punch of boxing for students. As for the research problem, it was that learning the basic skills, especially the straight punch, is done through the use of exercises and usual and recognized methods, which leads to boredom or boredom, and thus leads to difficulty and delay in learning the skill due to the lack of performance of the necessary repetitions by the students, which means that they will not have the time Sufficient to perform appropriate and sufficient repetitions.
Effect of Micro-Nutrients in Growth and Nutrient Uptake of Maize (Zea Mays L.)
Authors: Doruk Kasinam
Published: May 2022

The pot experiment was conducted in Department of Soil Science and Agricultural Chemistry . Annamalai university to evaluate the response of maize ( Zea mays L.) with conventional ,non – conventional organic source , industrial by-products combined with inorganic fertilizers. The treatments imposed were T_1-Control ( 100 % RDF ) , T_2- 100 % RDF + Municipal Solid Waste Compost @ 5 〖t ha〗^(-1) , T_3- 100 % RDF + Municipal Solid Waste Compost @ 〖10 t ha〗^(-1), T_4 – 100 % RDF + Vermicompost @ 2.5 〖t ha〗^(-1), T_5 – 100 % RDF + Vermicompost @ 5 〖t ha〗^(-1) , T_6-100 % RDF + Bagasse Ash @ 5 〖t ha〗^(-1) , T_7- 100 % RDF + Bagasse Ash @ 10 〖t ha〗^(-1) ,T_8- 100 % RDF + Lignite Flyash @ 5 〖t ha〗^(-1) ,T_9- 100 % RDF + Lignite Flyash @ 10 〖t ha〗^(-1).There were nine treatments combinations replicated thrice in CRD.The uptake of grain in Fe (5.495〖 mg pot〗^(-1)) ,Mn (0.592 〖mg pot〗^(-1)), Zn (0.746 m〖g pot〗^(-1)) and the uptake of grain in Cu (0.118 〖mg pot〗^(-1) ) recorded higher in the treatment ( T_3 ) which received 100 % RDF with Municipal Solid Waste Compost @ 10 tha^(-1).Stover uptake in Fe (44.0〖 mg pot〗^(-1)), Mn (3.25 〖mg pot〗^(-1)) , Zn (0.85 〖mg pot〗^(-1)) and Cu (0.72 〖mg pot〗^(-1)) was recorded highest due to application of 100 % RDF with Vermicompost @ 5 〖t ha〗^(-1) ( T_(5 )).