bluuebunny/crossref_metadata_2025 huggingface dataset:
PENDAMPINGAN PELAKU UMKM DALAM MENINGKATKAN PRODUKTIVITAS PENDAPATAN UMKM TAKOMA DI DESA WISATA SAIT BUTTU SARIBU KABUPATEN SIMALUNGUN
Authors: Sipayung Tuahman , Saragih Liharman , Munthe Risma N , Napitu Resna , Damanik Elfina O P , Kristianto  , Purba Johanes W P , Agung Yudha Permana  , Susan Pransiska  , Damanik Toga Hotdianto
Published: November 2024

Tujuan penelitian ini untuk mengetahui dan menganalisis manfaat digital marketing dalam meningkatkan penjualan UMKM di Kabupaten Simalungun. Teknik pengumpulan data melalui kuesioner dan wawancara yang dilakukan oleh peneliti kepada UMKM sebagai sampel. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling. Hasil penelitian menunjukkan bahwa para pelaku UMKM telah memanfaatkan digital marketing dalam memasarkan produnya tetapi pemahaman informan berkaitan dengan Digital Marketing yaitu Transaction Cost, Interactive, Interactive program dan Design Program sudah baik. Hak inilah yang menyebabkan pemanfaatan Digital Marketing oleh UMKM mampu meningkatkan penjualan secara maksimal
PENINGKATAN KAPASITAS UMKM MELALUI PENDAMPINGAN KEUANGAN DAN PENGELOLAAN USAHA
Authors: Saragih Afni Eliana , Ratnawati  , Filbert Ivander
Published: November 2024

UMKM masih menghadapi berbagai rintangan dalam berbagai bidang. Himpunan Pendamping dan Pengusaha Mikro Kecil Menengah Nusantara (HIMPUN) sebagai mitra sasaran juga menghadapi berbagai rintangan dalam menjalankan usahanya. Rintangan yang dihadapi UMKM HIMPUN berupa keterbatasan pengelolaan usaha dan pencatatan keuangan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kemampuan UMKM HIMPUN dalam mengelola usaha dan keuangan. Metode pelaksanaan yang dilakukan berupa pemberian materi oleh tim, diskusi, praktik, dan pendampingan langsung kepada UMKM. Materi yang diberikan diantaranya, pengantar laporan keuangan untuk pembiayaan modal usaha; optimasi google bisnis; optimasi whatsapp bisnis; optimasi facebook dan instagram ads; penggunaan AI untuk membuat konten; dan aplikasi keuangan bagi UMKM. Ipteks yang ditransfer kepada mitra berupa Aplikasi Keuangan yang diberi nama “UANGKU UMKM”. Luaran pengabdian masyarakat pemula ini adalah terjadinya peningkatan level keberdayaan mitra dalam aspek manajemen dan penggunaan teknologi keuangan
MICRO EMPOWERMENT : SOSIALIASI EDUKASI LAYANAN GADAI DI PEGADAIAN CABANG SERBELAWAN SIMALUNGUN
Authors: Saragih Liharman , Achichan Dani Grasella Natasya  , Dinda Maharani  , Putri Wahyuni  , Titania Dwi Ramadani
Published: November 2024

Pengabdian ini bertujuan untuk meningkatkan pemahaman masyarakat Serbelawan tentang manfaat Layanan Gadai yang ditawarkan oleh Pegadaian Cabang Serbelawan. Banyaknya masyarakat di daerah ini yang belum sepenuhnya memahami potensi Layanan Gadai sebagai solusi pemberdayaan mikro. Melalui program edukasi, sosialisasi dan pendampingan, masyarakat didorong untuk memanfaatkan layanan Pegadaian, seperti gadai BPKB dan kredit mikro, guna mendukung pengembangan usaha kecil dan menengah serta meningkatkan kesejahteraan ekonomi. Hasil kegiatan ini menunjukkan peningkatan literasi keuangan dan pemanfaatan layanan pegadaian dikalangan masyarakat setempat, terutama bagi pelaku usaha mikro
PENDAMPINGAN PENGUMPULAN DATA LINGKUNGAN UNTUK PENGELOLAAN LINGKUNGAN CERDAS (SMART ENVIRONMENT) DI DESA JAMALI
Authors: Prabawasari Veronika Widi , Paranita Asnur  , Aisyah  , Rehulina Apriyanti  , Wahyu Prakosa  , Budi Santosa
Published: November 2024

Kegiatan pengabdian ini bertujuan untuk mendukung pengumpulan data smart environmental di Desa Jamali, Kabupaten Cianjur, Jawa Barat. Program ini mengintegrasikan teknologi dengan pengelolaan lingkungan berkelanjutan untuk mengatasi berbagai masalah, seperti kekurangan air, polusi udara, dan inefisiensi dalam sektor pertanian. Dalam rangka mencapai tujuan ini, diskusi kelompok terarah (FGD) dan survei dilakukan untuk mengidentifikasi tantangan lingkungan utama. Hasilnya menunjukkan adanya penggunaan air tanah yang berlebihan oleh sektor peternakan, manajemen sampah yang buruk, serta pemanfaatan lahan pertanian yang belum optimal. Untuk mengatasi tantangan tersebut, sejumlah solusi direkomendasikan, termasuk penampungan air hujan, optimalisasi lahan pertanian, serta pengembangan ruang terbuka hijau yang dapat meningkatkan kualitas lingkungan. Inisiatif ini tidak hanya berkontribusi pada pengembangan desa cerdas di Indonesia, tetapi juga mendorong partisipasi aktif masyarakat dalam pelestarian lingkungan. Melalui program ini, diharapkan masyarakat dapat mengadopsi praktik berkelanjutan yang dapat memperbaiki kondisi lingkungan dan meningkatkan kualitas hidup mereka. Dengan mengintegrasikan teknologi dan pendekatan partisipatif, kegiatan ini diharapkan mampu memberikan dampak positif yang berkelanjutan bagi Desa Jamali dan sekitarnya. Selain itu, pengumpulan data yang efektif akan memfasilitasi perencanaan dan pengambilan keputusan yang lebih baik dalam pengelolaan sumber daya alam, sehingga memungkinkan desa ini untuk menjadi contoh bagi daerah lain dalam penerapan konsep desa cerdas. Melalui pelibatan semua pihak, dari pemerintah setempat hingga masyarakat, kolaborasi ini diharapkan dapat menginspirasi inisiatif serupa di wilayah lain
Besek Product Business in Improving Family Economy based on Islamic Economics
Authors: Jubaedi Ahmad , Asri Kholifatul Husna
Published: November 2024

Family economy is an important foundation in community life, including in Ciderum Village, Batukembar Village. This village relies mainly on agriculture and local crafts, with the majority of the population involved in these businesses. Unfortunately, the level of economic welfare of families in Ciderum Village is still below expectations, with many residents struggling to meet basic needs such as food, education, and health. In addition, the majority of the population of Ciderum Village are Muslims who practice the principles of Islamic economics, which emphasize justice, togetherness, and blessings in economic transactions. However, the application of these values ??has not been seen in daily economic activities in this village. In this context, besek products are a great opportunity to improve the family economy in Ciderum Village. Besek is a traditional craft that has existed for a long time in this village. By utilizing the potential of besek and implementing Islamic economics, we can improve the family economy in Ciderum Village. This study aims to investigate efforts to develop a besek product business based on Islamic economic principles in this village. The aim is to identify opportunities and challenges in implementing Islamic economics in the besek product business and to analyze its impact on the family economy in the village. This study uses a qualitative research method whose object of research is bamboo or besek craft business, including descriptive qualitative research. It is hoped that this study will provide practical guidance for the people of Ciderum Village in developing sustainable besek product businesses that are in accordance with Islamic economic values. In addition, the results of this study can also contribute to the development of a sustainable economy in rural areas, especially in Ciderum Village, and provide insight into the potential of Islamic economics in improving family welfare.
Odporność odmian pszenicy ozimej na fuzariozę kłosów powodowaną przez Fusarium culmorum (W. G. Smith) Sacc.
Authors: Góral Tomasz
Published: October 2024

Badano odporność 40 odmian pszenicy ozimej na fuzariozę kłosów. Większość odmian znajduje się obecnie w Krajowym Rejestrze odmian. Badania prowadzono w latach 2002–2004 na polach doświadczalnych IHAR Radzików. Kłosy pszenicy ozimej inokulowano izolatami Fusarium culmorum. Oceniano stopień porażenia kłosa, porażenie ziarniaków oraz redukcję komponentów plonu. Większość odmian była podatna na fuzariozę kłosów, z tym że wystąpiło znaczne zróżnico¬wanie tej cechy. Znaleziono zarówno odmiany o niskiej podatności na porażenie kłosa (np. Turnia, Alba, Tonacja, Liwilla), jak i liczne odmiany o bardzo wysokiej podatności (Liryka, Maltanka, Clever, Kris, Soraja). Część odmian podatnych (Begra, Kobra, Symfonia) wykazała tolerancję na porażenie kłosa przejawiającą się średnim porażeniem ziarniaków i średnią redukcją plonu. Równocześnie wśród odmian o niskim porażeniu kłosa obserwowano odmiany o znacznym porażeniu ziarniaków (Liwilla, Sukces, Wilga). Termin kwitnienia i wysokość odmian pszenicy ozimej miały istotny wpływ na obserwowane nasilenie fuzariozy kłosów. Odmiany wyższe były z reguły słabiej porażane przez F. culmorum niż odmiany niskie. Część odmian niskich i średniej wysokości wykazała odchylenie od tej zależności (np. Symfonia, Izolda, Sukces, Tonacja, Alba), co wskazuje, że mogą one posiadać geny odporności na fuzariozę kłosów.
Analisis Tecnology Acceptance Model pada Aplikasi Pembiayaan Kredit FIFGROUP Mobile Customer
Authors: Rohim Muhammat Hanafi Fathur , Wuryaningsih Wuryaningsih
Published: November 2024

Perkembangan teknologi telah mengubah paradigma layanan keuangan menjadi lebih terkoneksi dan inovatif. Namun, adopsi teknologi masih menjadi isu penting yang perlu dipahami dalam konteks aplikasi pembiayaan kredit. Penelitianl ini bertujuanl menganalisis faktor yang memengaruhi penggunaan aplikasi pembiayaan kredit pada pengguna Fifgroup Mobile Customer (FMC) denganl menggunakan model penerimaanl teknologi (TAM). Penelitianl ini melibatkan 145 pengguna aplikasi pembiayaan kredit (FMC) pada PT. FIFGROUP Cabang Malang. Metode penelitian yang dilakukan bersifat kuantitatif dan pengumpulan data dilakukan melalui penyebaran kuisioner. Pengolahan data dilakukan menggunakan software SmartPLS 4.0 untuk menguji hipotesis penelitian. Temuan dari penelitianl ini menunjukkanl bahwa persepsil kemudahanl penggunaan berpengaruhl signifikanl terhadapl persepsil manfaat, sikapl penggunaan, dan minatl menggunakan aplikasi
Pengungkapan Corporate Social Responsibility Dan Kinerja Keuangan Pada Perusahaan Manufaktur Sektor Barang Konsumsi
Authors: Iqbal M Choirul , Suhartini Dwi
Published: November 2024

Penelitian ini berupaya untuk mengetahui pengaruh ukuran dan umur perusahaan terhadap kinerja keuangan dengan menggunakan pengungkapan CSR sebagai variabel intervening. Fokus penyelidikannya adalah perusahaan manufaktur barang konsumsi yang terdaftar di BEI tahun 2019 - 2022. Metode purposive sampling dipakai untuk menetapkan sampel. Software WarPLS Versi 8.0 dipakai sebagai metode analisis data. Temuan penelitian menunjukkan bahwasanya kinerja keuangan suatu perusahaan menurun seiring dengan meningkatnya ukurannya. Di satu sisi lamanya umur perusahaan tidak menjamin berdampak pada kinerja keuagan yang baik. Kemudian ukuran perusahaan yang besar tidak menjamin keterlibatan perusahaan dalam aktivitas CSR, sedangkan perusahaan yang telah lama beroperasi maka semakin tinggi keterlibatan perusahaan dalam aktivitas CSR. Perusahaan yang sering terlibat dalam aktivitas CSR memiliki kinerja keuangan yang baik. Hasilnya Pengungkapan CSR tidak mampu memediasi hubungan ukuran perusahaan dan umur perusahaan terhadap kinerja keuangan perusahaan sebagai variabel intervening.
Pelatihan dan Pendampingan Pemetaan Gaya Belajar Peserta Didik Melalui Asesmen Diagnostik bagi Para Guru Sanggar Belajar Sekolah Indonesia Kuala Lumpur Malaysia
Authors: Abdul Aziz Khoiri  , Ahmad Fauzi Hendratmoko  , Rizky Putra Santosa  , Fafi Inayatillah
Published: November 2024

Asesmen diagnostik merupakan syarat penting dalam melaksanakan pembelajaran berdiferiensi. Namun, semua guru di Sanggar Belajar Sungai Mulia 5 belum memahami dan menerapkanya sebelum melakukan pembelajaran. Kegiatan pelatihan dan pendampingan ini bertujuan untuk peningkatan pedagogik guru di Sanggar Belajar Sungai Mulia 5. Kegiatan ini diikuti oleh 11 yang merupakan TKI yang bekerja di Malaysia. Adapun metode kegiatan pendampingan ini meliputi; presentasi, diskusi, tanya jawab, praktik. Sementara, kegiatan pelatihan dan pendampingan ini meliputi beberapa tahapan, diantaranya; (1) tahap inisiasi/persiapan, (2) tahap pelaksanaan/pendampingan, dan (3) tahap pasca-pelatihan/pendampingan.  Hasil pretes dan postes peserta pelatihan dan pendampingan menunjukan adanya peningkatan pemahaman materi dari  45,6 menuju 64,5  . Selain itu, hasil feedback peserta pendampingan menunjukkan bahwa materi pelatihan sangat sesuai dengan kebutuhan peserta pendampingan dan metode yang digunakan saat pendampingan sangat efektif.
PKM Pelatihan dan Pendampingan Perhitungan Harga Pokok Produksi dan Pengelolaan Keuangan Serta Peningkatan Penjualan Menggunakan Digital Marketing
Authors: Rahmadani  , Nurhaflah Soraya  , Sondang Beatrix Siahaan  , Muhammad Asrin Jazuli  , Tasya Melati Sulaiman  , Dara Anisa  , Muhammad Fatih Asykarillah Nasution  , Ahmad Luthfi Munawar  , Muhammad Yuan Aunhanief  , Andini Aura Fachrani
Published: November 2024

Program pengabdian masyarakat ini bertujuan untuk menyelesaikan masalah mitra terkait peningkatkan kemampuan Mitra dalam melakukan perhitungan harga pokok produksi dan laporan keuangan sederhana. Selain itu kegiatan PKM ini juga memberikan produk ke UMKM berupa program sederhana berbasis MS. Excel sehingga memudahkan bagi mitra dalam menyelesaikan permasalahan akuntansinya. Permasalahan lain yang diselesaikan adalah tentang pemanfaatan teknologi, yaitu terkait pemasaran melalui digital dengan memanfaatkan sosial media, marketplace. PKM ini penting bagi mitra untuk meningkatkan lagi usaha dan pada akhirnya akan mampu meningkatkan penjualan melalui perluasan pangsa pasar dengan menambah pelanggan dengan memanfaatkan digital marketing. Luaran yang ditargetkan adalah peningkatkan kemampuan mitra sehingga mitra menjadi lebih mandiri dan mampu meningkatkan pengelolaan keuangan terutama dalam menetapkan harga pokok produksi yang sesuai dengan standar dan pada akhirnya meningkatkan penjualan usaha dibarengin dengan peningkatan profit serta meningkatkan kesejahteraan pelaku UMKM.
KakaoMu: Inovasi Pertanian Kakao Pintar dengan Teknologi Digital Berbasis AI di Koperasi Tani Masagena
Authors: Anggra Alfian  , Rahmat Siswannto  , Sahrir  , Aulia Putri Azzahra  , Salmia
Published: November 2024

Daerah penghasil kakao yang utama di Sulawesi Selatan adalah Kabupaten Luwu dan Luwu Utara, yang produksi rata-ratanya melebihi 20 ribu ton per tahun. Akan tetapi, produksi kakao saat ini mengalami penurunan yang cukup siginifikan dalam beberapa tahun belakangan ini. Permasalahan turunnya produksi biji kakao ini disebabkan oleh beberapa faktor permasalahan budidaya, hama dan penyakit, pengalihan komoditas, industri pengolahan yang belum dikembangkan dengan skala besar, dan pemenuhan standar ekspor. Salah satu cara yang dapat digunakan untuk mengatasi masalah tersebut adalah dengan penerapan smart farming dengan integrasi digital berbasis artficial intelegence. Tujuan program pengabdian ini adalah untuk membuat aplikasi (all in) yang dapat digunakan untuk penanganan hama dan penyakit, informasi harga dan ketertelusuran pertanian kakao sehingga memenuhi standar ekspor. Aplikasi KakaoMu berbasis AI berhasil dikembangkan dan dapat digunakan sebagai salah satu solusi dalam menghadapi permasalahn pertanian kakao.
Understanding measles virus: from isolation to immunological cellular mechanisms and immunisation 1954–2024
Authors: Brown Brent , Imarogbe Chinua , Fricke Ingo
Published: November 2024

Measles virus (Morbillivirus abbreviated as MV, but more recently MeV) is the causal agent of measles disease, thought to have existed at least 4,000 years ago, affecting predominantly infants, but also immunocompromised individuals remaining a public health issue today globally. In this review, we discuss the historical background about MeV infection to modern-day research on measles disease, current epidemiology, but also what is known about immunisation against it. We report what is known about the viral structure and the function of the viral proteins. This additionally covers the cellular structure of MeV, mechanisms, and clinical aspects of infection. Including a review of topics like cellular receptor-associated entry factors, to the immunology of MeV infection. In this review, the current knowledge of innate immune responses during infection is explained, which involves changes to chemokine and cytokine expression, finalised by the present understanding of adaptive immune responses to MeV. The genomic stability of the MeV proteins is explained and suggestive that it could be the third pathogen with eradication potential (after the variola and rinderpest viruses). Further biological and immunological clarification as to how this could occur is explained below.
Preliminary evaluation of FAPI-04-PET/CT for differentiating recurrence and post-treatment changes in high-grade gliomas
Authors: Dev Indraja D. , Puranik Ameya D. , Rangarajan Venkatesh , Patra Sukriti , Purandare Nilendu , Sahu Arpita , Choudhary Amitkumar , Bhattacharya Kajari , Gupta Tejpal , Chatterjee Abhishek , Dasgupta Archya , Moiyadi Aliasgar , Shetty Prakash , Singh Vikas , Sridhar Epari , Sahay Ayushi , Shah Aekta , Ghosh Suchismita , Choudhury Sayak , Shah Sneha , Agrawal Archi
Published: November 2024

Fibroblast-activated protein (FAP) expression in glial cells is attributed to FAP-positive foci on tumor vessels and neoplastic cells. Preclinical and pilot studies have shown FAP expression in high-grade gliomas. We aimed at comparing PET imaging with FAP-inhibitor (FAPI-PET) with current standard, i.e., fluoro-ethyl tyrosine (FET) PET in post-treatment setting to differentiate recurrence and post-treatment changes. 6 patients with WHO Grade III and IV glioma who received standard treatment underwent Ga-68-FAPI-04 PET/CT (FAPI-PET/CT). Tracer uptake greater than background was considered positive. FET PET was performed and interpreted as per institutional standards, which formed the basis of treatment decision. There was concordance between FAPI expression and FET uptake in 5 patients suggestive of disease recurrence. There was no FAPI expression seen in 1 patient, in whom FET PET was suggestive of post-treatment changes. FAPI PET uptake correlated with amino acid expression to differentiate post treatment changes from recurrence in high-grade glial tumors; further validation with prospective study and histopathological confirmation is needed.
Strategi pengembangan personal branding wisata “lembah kecubung” desa penanggungan
Authors: Salwa Yasmin Az-Zahro  , Rr. Debby Amalia Azhari  , Akmad Varel Al Farabi  , Fairuz Zaky Muhammad  , Farhat Nur Rachman  , Supardi Supardi
Published: November 2024

Lembah Kecubung merupakan destinasi wisata baru yang terletak di Desa Penanggungan, Kecamatan Trawas, Kabupaten Mojokerto. Tempat ini sangat menarik karena menawarkan pemandangan yang sangat indah karena langsung mengarah ke Gunung Arjuno dan Penanggungan. Objek wisata ini berkonsep agrowisata dengan daya tarik utama edukasi melalui wahana alam seperti petik sayur, water tubing, mengeksplorasi strategi pengembangan personal branding untuk mempromosikan wisata Lembah Kecubung di Desa Penanggungan. untuk membangun personal branding yang kuat, strategi yang baik diperlukan, termasuk peningkatan visibilitas online melalui penggunaan konten yang menarik dan konsisten, kolaborasi dengan influencer lokal, dan pemanfaatan jaringan komunitas untuk meningkatkan kesadaran dan minat wisatawan. Tujuan dari strategi diharapkan personal branding wisata Lembah Kecubung dapat semakin dikenal, diminati, dan berkontribusi positif bagi perkembangan pariwisata Desa Penanggungan
Factors associated with completeness of basic immunization for babies at Simpangkatis health center in 2023
Authors: Monica  , Harmendo  , Muhammad Fahd Asmaruddin
Published: November 2024

The Simpangkatis Health Center is located in Simpangkatis Village, Simpangkatis District, Central Bangka Regency, Bangka Belitung. Immunization is very important for children's development and can prevent various dangerous diseases and disabilities such as chicken pox, polio, tuberculosis, and others. Based on data obtained from 2019 to 2022 for completeness of basic immunization in Central Bangka Regency, it can be concluded that completeness of basic immunization is still low. Central Bangka regency, especially at the Simpangkatis Community health Center, the completeness of immunization is still low every year. The aim of this research is to find out what is related to the completeness of basic immunization for babies at the Simpangkatis Health Center, Central Bangka Regency in 2023 because the data obtained shows that the fulfillment of complete basic immunization is quite low. This research method was carried out using analytical methods with a cross sectional study design. The data collection method used a questionnaire sheet and was carried out in September 2023. The sample for this research was 91 people. The results obtained showed that the mother's education level (p=0,025), mother's level of knowledge (p=0,024), mother's employment status (p=0,021), and family support (p=0,074). The conclusion is that there is a significant relationship between the level of maternal education, the level of maternal knowledge, and the mother's employment status with the completeness of basic immunizations for babies, while for family support there is no relationship with the completeness of basic immunizations for babies at Simpangkatis Health Center in 2023
Liukuportaat, karuselli vai kummitusjuna? Aktivointitoimenpiteiden tarkoitetut ja tarkoittamattomat seuraukset pitkäaikaistyöttömien nuorten haastattelupuheessa
Authors: Ylistö Sami
Published: November 2024

Erilaiset työllistämistoimenpiteet ovat keskeinen työvoimapoliittinen keino, jolla pyritään edistämään työttömien työllistymistä. Nuoret ovat olleet yksi keskeisimmistä näiden toimenpiteiden kohderyhmistä. Siitä huolimatta tällä hetkellä on saatavilla vain niukasti tutkimustietoa siitä, millaisia myönteisiä ja kielteisiä seurauksia työllistämistoimenpiteisiin osallistumisella on erityisessä syrjäytymisvaarassa oleville nuorille. Tässä artikkelissa tätä vaikeasti lähestyttävää ongelmaa tutkitaan pitkäaikaistyöttömien nuorten haastatteluaineiston pohjalta. Tutkimuksen tavoite on selvittää, millaisia toivottuja ja ei-toivottuja seurauksia työllistämistoimenpiteisiin osallistumisella on ollut pitkäaikaistyöttömien nuorten itsensä arvioimana. Aineisto sisältää 28 pitkäaikaistyöttömän nuoren elämänkulkuhaastattelua, joita on analysoitu temaattisen narratiivisen analyysin avulla. Tulosten tulkinnan teoreettisena viitekehyksenä käytetään Anthony Giddensin rakenteistumisteoriaa. Analyysissä nuorten kokemukset tiivistetään kolmeen tarinatyyppiin, jotka ovat aktivoinnin liukuportaat, karuselli ja kummitusjuna. Nämä tarinatyypit kuvaavat erilaisia työllistämistoimenpiteiden seurauksia pitkäaikaistyöttömien nuorten kokemusten näkökulmasta. Tutkimus osoittaa, että työllistämistoimenpiteet voivat auttaa nuoria murtamaan työttömyyttä ylläpitävän noidankehän, mutta työllistämistoimenpiteisiin osallistumiseen sisältyy myös huomattavia riskejä.
Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis
Authors: Sun Hong-Wei , Bai Yong-Yu , Qin Zhen-Liu , Li Ri-Zhao , Madzikatire Tinotenda Blessing , Akuetteh Percy David Papa , Li Qiang , Kong Hong-Ru , Jin Yue-Peng
Published: October 2024

BACKGROUND

Acute pancreatitis (AP), the initially triggered inflammatory process in the pancreas, can be life-threatening. It has been reported that 15-lipoxygenase may promote the removal of damaged intracellular components, maintain intracellular homeostasis, and promote apoptosis by upregulating the activity of caspases. Despite an increased understanding of the lipoxygenase pathway in inflammation and immune diseases, the role of the Alox15 gene product in modulating the inflammatory changes during AP is not well defined.

AIM

To investigate the effect of Alox15 expression in cerulein-induced AP in rats.

METHODS

Model rats were transfected with Alox15 by injecting a recombinant lentivirus vector encoding Alox15 into the left gastric artery before inducing AP. The expression of Alox15 was then assessed at the mRNA and protein levels.

RESULTS

Our in vivo results showed that serum amylase activity and pancreatic tissue water content were significantly reduced in Alox15 -transfected rats. Further, the mRNA expression levels of tumor necrosis factor alpha, interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1, as well as the protein expression of nuclear factor kappa B in pancreatic tissue were reduced. Additionally, we observed an upregulation of cleaved caspase-3 that implies an induction of apoptosis in pancreatic cells. The transfection of Alox15 resulted in a lower number of autophagic vacuoles in AP.

CONCLUSION

Our findings demonstrate a regulatory role of Alox15 in apoptosis and autophagy, making it a potential therapeutic target for AP.
Prediction of Netflix Content Viewing Time Using a Machine Learning Classification Model
Authors:   The Korean Data Analysis Society, Ko SeonJe , Kim Iljoo
Published: October 2024

The OTT (over-the-top) market has become the center of the media industry, showing rapid growth since COVID-19, and the competitiveness of an OTT platform largely depends on the quality and quantity of its contents. In this environment, this study aims to develop a model that can predict viewing time of each content based on its characteristics, utilizing machine learning techniques and the recent viewership data released by Netflix. This study used content characteristics data collected from IMDB and TMDB as predictor variables, and developed classification models applying Random Forest, Support Vector Machine (SVM), and XGBoost algorithms. The performance of each model was evaluated using Confusion Matrix and the AUC (area under the ROC curve) measure. As a result, all three algorithms showed good performance and XGBoost has demonstrated the best performance. The proposed model is expected to support OTT platforms to make a better decision on purchasing content licences or making original contents by effectively predicting the success or failure of the content in advance.
Climate Skepticism Network and Influencer Message Structures on Social Media using Big Data: Application of Social and Semantic Network Analyses
Authors:   The Korean Data Analysis Society, Park Sejung
Published: October 2024

This study examines the information structure, message dissemination patterns, and influencer characteristics of social media users who spread climate change skepticism messages using social and semantic network analysis based on big data. Compared to a random network model, the climate skepticism network exhibits a small-world network structure, with messages led by climate change deniers spreading easily and quickly. The skepticism network is formed by a few large communities and a majority of smaller ones, with users tending to communicate strongly within their communities. The authority group in the network frequently raised conspiracy theories related to climate issues and highlighted farmer protests against Europe's Green Deal and carbon neutrality policies. The network's broadcaster group, on the other hand, tended to mock or criticize climate policy advocates in a harsh tone, often denying scientific evidence. The results can be used to inform the development of climate campaigns.
The Relationship Between Environmental Policy and Productivity Considering Dynamic Perspective: Focusing on Manufacturing Firms
Authors:   The Korean Data Analysis Society, Lee Jinhee , Song Cheol Jong
Published: October 2024

This study analyzed the effect of increasing environmental policy stringency on a firm's TFP from a dynamic perspective. For the analysis, the TFP of Korean manufacturing firms was estimated from 2006 to 2018, and the OECD's environmental policy stringency index was used. The baseline model was set to represent that one-year lag of environmental policy stringency affects TFP. And environmental policy stringency was considered by dividing it into Korea's environmental policy stringency and relative environmental policy stringency. The analysis model took a dynamic perspective by considering the persistence of TFP shock and the persistence of environmental policy stringency. Dynamic panel analysis was conducted to consider the persistence of TFP shocks, and the Porter hypothesis was tested by changing the time lags of environmental policy stringency. As results, it was found that the increase in one-year lag of environmental policy stringency decreased firm's TFP. This was shown in Korea's environmental policy stringency as well as in the relative environmental policy stringency. However, the increases in two-year and three-year lags of environmental policy stringency were shown to lead to productivity improvement, showing that the Porter hypothesis was supported after two periods. This result supports the Porter hypothesis as a more long-term phenomenon.
Sanitation Control of Ferry Ports in Tanjung Harapan Harbor
Authors: Pramawati Anita , Novelasari Novelasari , Aryanti Aryanti , Lubis Abdillah
Published: October 2024

Environmental sanitation is an activity to create healthy environmental conditions in the port area. Good sanitation conditions can prevent disease transmission. Sanitary conditions in the Port of Tanjung Harapan Selat Panjang are not good enough, characterized by rat catching which increases every year, poor drainage conditions, and inadequate sanitation facilities. The purpose of this study is to evaluate the management of sanitation at Tanjung Harapan Harbor in Selat Panjang to become input material to make it better in the future. This research uses a qualitative method with a system approach based on input, process and output where the data collected comes from interviews, observation and documentation and is analyzed using triangulation. Sanitary management of the Port of Tanjung Harapan Selat Panjang is managed by port management and supervised by the Port Health Office. Sanitary management at the Port of Tanjung Harapan Selat Panjang is already running but not optimal, there are still obstacles from the aspects of human resources, large financing and inadequate infrastructure such as the unavailability of TPS and WWTP for waste management. Port sanitation management must be maintained to prevent the development of disease vectors and transmission of various types of diseases. The need for good cooperation between the manager and the Port Health Office to create a healthy port.
Anesthesia Management of Patients with Esophageal Atresia/Traceoesophageal Fistula undergoing Thoracostomy and Esophagostomy Procedures
Authors: Marthendro Triade , Hidayat Nopian , Ananda Pratama
Published: November 2024

Esophageal atresia is a congenital disorder characterized by a disruption in the continuity of the esophageal lumen. Esophageal atresia may be accompanied by tracheoesophageal fistula, which is a lumen connection between the proximal and or distal part of the esophagus and the airway (trachea). Type C atresia is the most prevalent, which is approximately 88.5% to 90% of cases, where there is proximal esophageal atresia with distal tracheoesophageal fistula. In this case, a 9-day-old infant was admitted to Arifin Ahmad Hospital for thoracostomy and esophagostomy surgery due to continuous mucus discharge. The patient underwent awake intubation and was positioned intraoperatively, with a tilt to the right when an orogastric tube was placed. During surgery, the patient maintained stable hemodynamic and was subsequently admitted to the NICU using a ventilator. Infants with esophageal atresia often show symptoms of hypersalivation and shortness of breath caused by aspiration pneumonia. When the nasogastric tube cannot pass through the esophagus, atresia can be suspected. Radiology studies play an important role in diagnosing esophageal atresia, confirming esophageal atresia with or without fistula and diagnosing other anomalies associated with VACTERL.
Enhancing SME performance through innovation: evidence from a transition economy – Kosovo
Authors: Mulolli Enis , Islami Xhavit , Hashani Medain
Published: October 2024

Purpose – What are the effects of implementing various types of innovation, including product, process, and technological innovations, on the performance of SMEs in the manufacturing sector? This is a question that preoccupies us a lot. This study seeks to examine the individual and integrated effects of these innovations. Indeed, we examine the impact of three categories of innovation – product, process, and technological innovation – on the performance of SMEs in the manufacturing industry. Research methodology – We used a quantitative approach to execute this research, selecting SMEs at random using self-administered questionnaires. The data collected from 153 manufacturing SMEs was analyzed using hierarchical linear regression to investigate, evaluate, and refine the relation among product, process, and technological innovation and SME performance. Findings – This study’s findings reveal a clear and direct relationship between these three forms of innovation and SMEs’ performance. This study also provides empirical evidence that various forms of innovation, either examined individually or as integrated, exert a positive effect on the performance of SMEs in the manufacturing industry. Limitations – This study focuses on Kosovo-based SMEs, with the assumption of an upright connection between variables. Future studies can examine the existence of reverse causality in a variety of regional, cultural, and industrial settings. Originality/Value – This study significantly advances existing knowledge by providing useful insights into the complex interplay among product, process, and technological innovation (examined from both individual and integrated perspectives) as well as the performance of SMEs in the manufacturing industry.
Experimental and Computational Study of Ethanolamine Ices under Astrochemical Conditions
Authors: Ramachandran R. , Sil Milan , Gorai Prasanta , Meka J. K. , Sundararajan Pavithraa , Lo J.-I. , Chou S.-L. , Wu Y.-J. , Janardhan P. , Cheng B.-M. , Bhardwaj Anil , Rivilla Víctor M. , Mason N. J. , Sivaraman B. , Das Ankan
Published: November 2024

Ethanolamine (NH2CH2CH2OH) has recently been identified in the molecular cloud G+0.693-0.027, situated in the SgrB2 complex in the Galactic center. However, its presence in other regions, and in particular in star-forming sites, is still elusive. Given its likely role as a precursor to simple amino acids, understanding its presence in the star-forming region is required. Here, we present the experimentally obtained temperature-dependent spectral features and morphological behavior of pure ethanolamine ices under astrochemical conditions in the 2–12 μm (MIR) and 120–230 nm (VUV) regions for the first time. These features would help in understanding its photochemical behavior. In addition, we present the first chemical models specifically dedicated to ethanolamine. These models include all the discussed chemical routes from the literature, along with the estimated binding energies and activation energies from quantum chemical calculations reported in this work. We have found that surface reactions CH2OH + NH2CH2 → NH2CH2CH2OH and NH2 + C2H4OH → NH2CH2CH2OH in warmer regions (60–90 K) could play a significant role in the formation of ethanolamine. Our modeled abundance of ethanolamine complements the upper limit of ethanolamine column density estimated in earlier observations in hot core/corino regions. Furthermore, we provide a theoretical estimation of the rotational and distortional constants for various species (such as HNCCO, NH2CHCO, and NH2CH2CO) related to ethanolamine that have not been studied in existing literature. This study could be valuable for identifying these species in the future.
Direct Observations of a Shock Traversing Preceding Two Coronal Mass Ejections: Insights from Solar Orbiter, Wind, and STEREO Observations
Authors: Chi Yutian , Shen Chenglong , Zhang Zhiyong , Xu Mengjiao , Mao Dongwei , Liu Junyan , Wang Can , Yu Bingkun , Luo Jingyu , Zhong Zhihui , Wang Yuming
Published: November 2024

The three successive coronal mass ejections (CMEs) that erupted from 2023 November 27–28, provide the first opportunity to shed light on the entire process of a shock propagating through, sequentially compressing, and modifying two preceding CMEs using in situ data from Solar Orbiter, Wind, and STEREO-A. We describe the interaction of the three CMEs as follows: CME-1 and CME-2 interacted with each other at distances close to the Sun. Subsequently, the shock (S3) driven by CME-3 caught up with and compressed ICME-2 before 0.83 au, forming a typical shock–ICME interaction event observed by the Solar Orbiter. The S3 continued to propagate, crossing ICME-2 and propagating into ICME-1 as observed by Wind, and completely overtaking both ICME-1 and ICME-2 at STEREO-A. The interaction between S3 and the preceding two ICMEs leads to a clear compression of preceding ICMEs including an increase in magnetic field (∼150%) and a reduction in the interval of ICMEs. It presents direct and compelling evidence that a shock can completely traverse two preceding CMEs, accompanied by a significant decrease in shock strength (magnetic compression ratio decrease from 1.74 to 1.49). Even though the three ICMEs interact significantly in the heliosphere, their magnetic field configurations exhibit coherence at different observation points, especially for ICME-3. Those results highlight the significant implications of shock–CME interactions for CME propagation and space weather forecasting.
Incidence ofPneumocystis jiroveciiPneumonia and Prophylaxis-Associated Adverse Events Among Patients With Systemic Lupus Erythematosus
Authors: Jiang Yiran , Duarte-García Alí A. , Putman Michael S. , Gazeley David J.
Published: November 2024

Objective

Pneumocystis jiroveciipneumonia (PJP) is an opportunistic infection that may affect patients with systemic lupus erythematosus (SLE). The objective of this project was to describe the incidence of PJP among patients with SLE.

Methods

A retrospective cohort analysis of the TriNetX database was conducted. Included patients had ≥ 2 International Classification of Diseases, 9th or 10th revision, Clinical Modification (ICD-9-CM/ICD-10-CM) codes for SLE separated by at least 30 days and were new users of mycophenolate mofetil (MMF) and/or cyclophosphamide (CYC). The incidence of PJP over the first 6 months of therapy was calculated; adverse events were assessed using incidence rate ratios (IRR) and Cox proportional hazards regressions.

Results

A total of 6017 patients with SLE were identified. Most were female (n = 5176, 86%) and Black or African American (n = 2138, 35.5%). Induction medications included MMF (n = 5208, 86.6%), CYC (n = 505, 8.4%), or both (n = 304, 5.1%); the most common PJP prophylaxis was trimethoprim-sulfamethoxazole (n = 1126, 18.7%). Five PJP cases were identified over 2752 person-years (PYs), one of whom received PJP prophylaxis, for an incidence rate of 1.8 cases/1000 PYs. In the adjusted analysis, patients who received prophylaxis had a higher risk of neutropenia (hazard ratio [HR] 2.5, 95% CI 1.4-4.4), leukopenia (HR 1.9, 95% CI 1.3-2.8), nephropathy (HR 1.7, 95% CI 1.4-2.1), and hyperkalemia (HR 1.4, 95% CI 0.9-2.0).

Conclusion

PJP rarely affects patients with SLE undergoing therapy with MMF and/or CYC; prophylaxis against PJP is associated with adverse events. The majority of patients with SLE and PJP had structural lung disease. These data do not support universal prescribing of PJP prophylaxis for patients with SLE without lung disease.
The Lived Experiences of Older Adults With Systemic Lupus Erythematosus: Patient Perspectives
Authors: Lieber Sarah B. , Young Sarah R. , Shea Yvonne , Gottesman Sarah P. , Lipschultz Robyn , Sun Dongmei , Reid M. Carrington , Mandl Lisa A. , Navarro-Millán Iris
Published: November 2024

Objective

Little is known about perceptions of aging among individuals with systemic lupus erythematosus (SLE). Gaining this knowledge could help to identify targets for future behavioral interventions aimed at successful aging with SLE. This qualitative study sought to elicit the lived experiences and essence of aging from older adults with SLE.

Methods

We conducted semistructured interviews with adults aged ≥ 65 years with SLE seen at a single tertiary center. Qualitative data were analyzed thematically using a phenomenological approach. We collected data on sociodemographic characteristics and disease features prior to each qualitative interview.

Results

Among 30 participants with a mean age of 71.3 years and mean SLE duration of 26.3 years (range 5-62 yrs), 4 overarching themes emerged to describe the essence of aging with SLE: SLE and comorbid conditions, cumulative effect of SLE symptoms, SLE disease trajectory, and self-perceptions of aging. Older adults with SLE shared variable aging experiences, including perspectives on multimorbidity and disease trajectory, as well as self-perceptions of aging.

Conclusion

We identified both positive and negative self-perceptions of aging, often informed by participants' lived experiences of cumulative effects of SLE symptoms and SLE disease trajectory, and underscoring the diversity of their experiences. Understanding self-perceptions of aging in this population could inform the development of evidence-based strategies to empower older adults with SLE to harness their positivity and resilience, and thus improve health-related outcomes, including health-related quality of life.
Le contrôle a priori de la surveillance exploratoire des correspondances : examen des cas britannique et français à partir de l’arrêt Big Brother Watch de la CEDH
Authors: Christodoulou Michail
Published: October 2024

L’importance que revêt la garantie procédurale du contrôle en amont de la mise en œuvre des techniques de surveillance exploratoire (telles la bulk interception britannique et la surveillance internationale française) dans la jurisprudence (supra)nationale, nous invite à regarder de plus près l’objet sur lequel porte le contrôle en question. Le fait que ce dernier soit assuré par une autorité indépendante de l’exécutif avec avis contraignant ne préjuge pas de son efficacité. La question de l’étendue de ce contrôle a priori est toute aussi déterminante.
mas et fam 2024 : état des lieux et perspectives
Authors: Gabbaï Philippe
Published: October 2024

Lieux d’accueil et de soin d’une clinique de l’extrême, mas et fam cristallisent les problématiques d’un secteur médico-social en grande difficulté. Enjeux diagnostiques et thérapeutiques des personnes accueillies, malaise des équipes professionnelles face à la disqualification de leurs repères théoriques et pratiques, nouvelles orientations impératives des cultures institutionnelles, partenariat complexe avec des familles face à la gravité des situations vécues et l’avancée en âge des patients : tels sont les thèmes abordés.
L’hospitalité : reconnaître, accueillir, accompagner la douleur
Authors: Grimaud Lin , Miedzyrzecki Jacques
Published: October 2024

Présenté dans le cadre du Café psy consacré à l’hospitalité, ce texte nous invite à comprendre ce qu’est la douleur, combien elle est malaisée à exprimer, attaquant chez chacun des zones de perception et des ressentis psychiques différents. Au-delà de l’indispensable sédation, réussir à la mettre en mots et à la partager avec quelqu’un permet de dépasser la dimension somatopsychique pour la transformer en une souffrance, susceptible d’un travail d’élaboration psychique en relation avec un tiers.
Réseaux de communications sur constellations de satellites
Authors: Baccelli François
Published: October 2024

Cet article, qui est issu du rapport de l’Académie des Sciences « Grandes constellations de satellites : enjeux et impacts », a pour objectif de décrire l’organisation, les fonctionnalités et les perspectives des réseaux de communications utilisant des constellations de satellites.Il se concentre sur les fonctionnalités de communications haut débit. Il décrit les architectures utilisées ainsi que les caractéristiques générales des satellites qui composent ces constellations. Il décrit aussi les principes régissant les communications entre les divers éléments du réseau. Il passe en revue les perspectives à plus long terme de cette classe de réseaux.
Les apports de Gaia-X
Authors: Gronlier Pierre , Taillandier Anne-Sophie
Published: October 2024

Gaia-X, créée en 2020, par les gouvernements allemand et français, vise à créer une infrastructure de données fédérée garantissant la souveraineté et la transparence des données, soutenant ainsi l’économie numérique de l’Europe. Avec plus de 300 membres, Gaia-X promeut l’interopérabilité et la sécurité grâce à un cadre normalisé, facilitant le partage des données tout en maintenant le contrôle et la conformité avec les réglementations européennes telles que le RGPD. Elle met l’accent sur l’autonomie technique, opérationnelle et juridique, en encourageant les stratégies multi- cloud afin de réduire la dépendance à l’égard des fournisseurs non européens. L’architecture de Gaia-X s’appuie sur des vocabulaires normalisés, des références vérifiables chiffrées et un registre de confiance pour garantir des échanges de données sécurisés et vérifiables. L’initiative soutient également le développement de l’IA en garantissant la traçabilité des données et le consentement, conformément à des réglementations telles que l’IA Act.À l’avenir, Gaia-X vise à intégrer les réglementations futures, en fournissant une couverture complète pour les fournisseurs de données et les consommateurs, favorisant ainsi un écosystème numérique digne de confiance.
Nouvelles technologies optiques, quel impact sur les systèmes de réalité augmentée de demain ?
Authors: Bougrenet de la Tocnaye Jean-Louis de
Published: October 2024

La réalité augmentée (RA) a souvent progressé à la faveur de sauts technologiques. Ce fut le cas avec la miniaturisation des afficheurs, des pico-projecteurs et des combineurs. Les dernières avancées dans le secteur de la conception/fabrication d’optiques, dites à effet de surface ( e.g. méta-surface, -lentille et -forme) aurontelles le même impact sur les dispositifs de projection des futurs systèmes RA ? Des avancées ont déjà eu lieu dans ce domaine avec les freeforms . De la même façon, le développement de la RA holographique, porté par la montée en puissance dans le domaine consumer des lunettes intelligentes, imposera-t-il ce choix à l’ensemble des dispositifs RA ? Autant de questions qui seront brièvement abordées dans cet article, consacré à la couche optique des systèmes RA. Enfin, dans cette course permanente vers toujours plus d’immersivité et du plus près de l’œil, les lentilles de contact seront-elles le futur de la RA hyper-immersive ? Quelles sont les dimensions ultimes que l’on pourra raisonnablement atteindre ? Autant de questions que l’on tentera d’aborder ici.
Apport de l’infrastructure de partage de données Agdatahub dans le secteur agri-agro
Authors: Picardat Sébastien
Published: October 2024

Ultra-connectée, la Ferme France génère énormément de données. L’infrastructure de partage de données Agdatahub est le tiers de confiance du secteur agricole et agroalimentaire via lequel les données peuvent circuler en conformité avec le cadre réglementaire européen. En effet, la plateforme française est un outil technologique et opérationnel qui répond aux objectifs de durabilité, d’innovation et de souveraineté poursuivis par les acteurs des filières. En tant qu’intermédiaire de données, statut inscrit dans la réglementation européenne et la loi française, Agdatahub simplifie et sécurise la circulation des données agricoles et traite les cas d’usage jugés prioritaires comme la génétique animale, la réduction du carbone, l’affichage environnemental, etc.