bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Study of the Blade Number and Airfoil Profile Impacts on the Twist/Chord Distribution of a Small Wind Turbine Blade
Authors: Akbari Vahid , Naghashzadegan Mohammad , Kouhikamali Ramin , Yaïci Wahiba
Published: August 2023

The blade number and airfoil profile effects on the blade shape of a small horizontal-axis wind turbine (SHWT) were investigated. For this purpose, the NACA4412, SG6042, and SG6043 airfoils, as well as 2, 3, and 4 blades, were considered. Then, two optimization processes were used: first, the blades were designed to maximize the power coefficient (

C

p

), and then a multiobjective optimization that included both maximizing

C

p

and maximizing the starting torque (

Q

s

) was employed. The differential evolution (DE) algorithm was employed to perform the optimization, and the blade element momentum aerodynamic approach was used to conduct the relevant computations. Also, to ensure the performance of the optimal blades, the computational fluid dynamics method was employed as well. The findings revealed that regardless of the number of blades and the type of airfoil, raising the twist angle (

θ

p

) and chord length (

c

) along the radial direction of the blade, especially at the root part, helps increase the

Q

s

. It was observed that increasing the number of blades does not have a significant effect on the

θ

p

distribution of the selected airfoils, but the

c

of the blades fitted with all three airfoils decreases. Regardless of the number of blades, while the geometry of blades utilizing the NACA4412 and SG6042 airfoils are close to each other, the blade with the SG6043 airfoil has the shortest

c

, which reduces the generated

Q

s

of blades fitted with this airfoil. The results also establish that by increasing the number of blades from 2 to 3, the power coefficient (

C

p

) of the blades fitted with all three airfoils increases, but by further increasing the number of blades from 3 to 4, the change in

C

p

completely depends on the airfoil profile.
Supplementary Table S1 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Table S1
Supplementary Figure S9 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S9. Mcl-1 is not responsible for LNS8801-induced death in AML (A) Proliferation assay dose curve of AML cells treated with the Mcl-1 specific inhibitor S63845. Cells were treated with drug for 72 hours. 6 replicates were used per dose. (B) Western blot of U937 cells overexpressing Mcl-1, treated with 250nM LNS8801 for 24 hours. (C) Annexin V flow analysis of U937 cells overexpressing Mcl-1. Cells were treated for 72 hours. 3 replicates were used per condition. Two-way ANOVA was used for statistical analysis for Annexin V+ flow cytometry comparing wild-type and Mcl-1 overexpressing U937 cells.
Supplementary Figure S8 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S8. LNS8801 depletes Mcl-1 in AML cells while not altering other Bcl-2 family proteins (A and B) (A) Western blot of pro-apoptotic proteins from U937 cells treated with 250nM LNS8801 as a time course. (B) Western blot of anti-apoptotic proteins treated with 250nM LNS8801 for 24 hours.
Supplementary Figure S7 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S7. LNS8801-induced AML inhibition is independent of classical GPER signaling (A) Annexin V+ flow cytometry analysis of U937 cells treated with 250nM LNS8801, 10uM Forskolin, 100uM EPAC-specific cAMP (8-pCPT-2'-O-Me-cAMP), and 100uM PKA-specific cAMP (N6-benzoyl-cAMP). Cells were incubated for 24 hours. 3 replicates per condition were used. (B) Detection of intracellular calcium upon drug treatment via a spectrofluorimeter assay. Fura2-AM dye was used for detection. 25nM E2, 250nM LNS8801, 1uM Ionomycin, 2uM thapsigargin, and 100uM histamine were used. 3 replicates were used per condition.
Supplementary Figure S6 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S6. LNS8801 induces heterogeneous phosphorylation of CREB in AML (A) Western blot showing AML cell lines treated with either vehicle DMSO or 250nM LNS8801. Cells were treated for 30 minutes. pCREB quantification was normalized to CREB and Actin. (B) Western blots of primary AML samples treated with different doses of LNS8801. Cells were incubated for 1 hour. pCREB quantification was normalized to CREB and Actin.
Supplementary Figure S5 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S5. GPER knockdown in MOLM14 Western blot of GPER knockdown clones of MOLM14 cells.
Supplementary Figure S4 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S4. Colony morphology of human AML cells and normal mononuclear cells (A and B) Brightfield image of colony formation of primary AML cells treated with (A) DMSO and (B) 250nM LNS8801. (C-H) Brightfield image of normal mononuclear cell colony morphologies.
Supplementary Figure S2 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S2. Human AML cell lines, primary MNC, and AML cells express GPER (A and B) Western blot of GPER expression in (A) AML cell lines, (B) normal mononuclear cells (MNC), and primary human AML samples. (C) Western blot of a primary AML sample treated with 250nM LNS8801 and/or 1uM G36. Cells were pretreated with G36 for 1 hour and treated with LNS8801 for 1 hour after pretreatment.
Supplementary Figure S12 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

(A and B) Western blots of (A) U937 and (B) MOLM14 cells treated with 25nM estradiol (E2) or 50nM thapsigargin (Tg) for indicated time. Western blot quantification was done by normalizing each band to its respective actin band.
Supplementary Figure S11 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

(A and C) Representative DCF histograms of (A) U937 and (C) MOLM14 cells treated with 250nM LNS8812 or 250nM LNS8801 at indicated time points. (B and D) Summary graph of median fluorescence intensity (MFI) of (B) U937 and (D) MOLM14 cells treated with 250nM LNS8812 or 250nM LNS8801. 3 replicates were analyzed per condition. Statistical analysis was done via one-way ANOVA with multiple comparisons was used for panels B and D (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).
Supplementary Figure S10 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S10. LNS8801 induces cell death independently of the classical secreted death ligands (A) Time course western blot of U937 cells treated with 250nM LNS8801. (B) Annexin V staining flow analysis of U937 cells treated with either 20ng/mL TNF⍺, 10ug/mL TNFR1 antibody, or 250nM LNS8801. Cells were incubated for 72 hours. 3 replicates were used per condition. (C) Annexin V staining flow analysis of U937 cells treated with LNS8801-treated U937 conditioned media. Cells were incubated in conditioned media for 72 hours. 3 replicates were used per condition. One-way ANOVA was used for statistical analysis (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).
Supplementary Figure S1 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S1. AML cells are particularly sensitive to LNS8801 (A-F) Proliferation assay performed with (A) A375, (B) WM46, (C) Mel290, (D) PANC-1, (E) MiaPaca-2, and (F) U937 cells. Dotted line represents the number of cells seeded. Cells were treated with 250nM LNS8801 for 72 hours. 5 replicates were used per condition per cell line. P values were calculated via pairwise t-tests (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).
FIGURE 2 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

LNS8801 inhibits AML colony formation. A, Colony formation assay of primary AML cells in either DMSO or 250 nmol/L LNS8801. Three replicates were used per condition. B, Colony formation of normal mononuclear cells in either DMSO or 250 nmol/L LNS8801. Three replicates were used per condition. CFU: Colony forming units. BFU: Blast forming units. CFU-G: CFU-granulocytes. CFU-M: CFU-monocytes. CFU-GM: CFU-granulocyte/monocyte. BFU-E: BFU-Erythrocytes. CFU-GEMM: CFU-granulocyte/erythrocyte/monocyte/megakaryocyte. CFU-E: CFU-erythrocyte P values were calculated using t tests (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001).
FIGURE 1 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

GPER agonist LNS8801 inhibits AML in vitro. Structure of LNS8801 (A) and LNS8812 (B). Concentration–response curves done with G-1, LNS8801, and LNS8812 in U937 (C), MOLM14 (D), HL60 (E), and THP1 (F) AML cell lines. Cells were incubated with the respective drugs for 72 hours. Relative cell count was determined using WST-8 dye. Six replicates were used per condition. Cell-cycle analysis done with PI staining in U937 (G), MOLM14 (H), HL60 (I), and THP1 (J) treated. Cells were treated with 250 nmol/L LNS8801 for 20 hours. Three replicates were used per condition. P values were calculated via pairwise t tests for G–J (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001).
Graphic Intelligent Diagnosis of Hypoxic-Ischemic Encephalopathy Using MRI-Based Deep Learning Model
Authors: Tian Tian , Gan Tongjia , Chen Jun , Lu Jun , Zhang Guiling , Zhou Yiran , Li Jia , Shao Haoyue , Liu Yufei , Zhu Hongquan , Wu Di , Jiang Chengcheng , Shao Jianbo , Shi Jingjing , Yang Wenzhong , Zhu Wenzhen
Published: August 2023

Introduction: Heterogeneous MRI manifestations restrict the efficiency and consistency of neuroradiologists in diagnosing hypoxic-ischemic encephalopathy (HIE) due to complex injury patterns. This study aimed to develop and validate an intelligent HIE identification model (termed as DLCRN, deep learning clinical-radiomics nomogram) based on conventional structural MRI and clinical characteristics. Methods: In this retrospective case-control study, full-term neonates with HIE and healthy controls were collected in two different medical centers from January 2015 to December 2020. Multivariable logistic regression analysis was implemented to establish the DLCRN model based on conventional MRI sequences and clinical characteristics. Discrimination, calibration, and clinical applicability were used to evaluate the model in the training and validation cohorts. Grad-class activation map algorithm was implemented to visualize the DLCRN. Results: 186 HIE patients and 219 healthy controls were assigned to the training, internal validation, and independent validation cohorts. Birthweight was incorporated with deep radiomics signatures to create the final DLCRN model. The DLCRN model achieved better discriminatory power than simple radiomics models, with an area under the curve (AUC) of 0.868, 0.813, and 0.798 in the training, internal validation, and independent validation cohorts, respectively. The DLCRN model was well calibrated and has clinical potential. Visualization of the DLCRN highlighted the lesion areas that conformed to radiological identification. Conclusion: Visualized DLCRN may be a useful tool in the objective and quantitative identification of HIE. Scientific application of the optimized DLCRN model may save time for screening early mild HIE, improve the consistency of HIE diagnosis, and guide timely clinical management.
The Influence of Funding Decision, Investment Decision Profitability and Sales Growth on Company Value in Mining Sector Companies Listed in Indonesia Stock Exchange 2017-2021 Period
Authors: Panjaitan Rike Yolanda , Simanjuntak Arthur , Pasaribu Dompak , Simanjuntak Gracesiela Y. , Silalahi Mulatua , Torong Natalia Agata
Published: August 2023

This study aims to determine and analyze how much influence of Funding Decision, Investment Decision, Profitability and Sales Growth partially and simultaneously On Firm Value In Mining Sector Companies Listed In Indonesia Stock Exchange 2017-2021 Period. Detemination of the sample used in this study by purposive sampling technique totaling 12 mining companies listed in Indonesia Stock Exchange 2017-2021 period. The data analysis method used in this research is multiple linear regression analysis. The result of the study show that funding decision variable have a positive and significant effect on firm value, investment decision variable has a negative and insignificant effect on firm value, profitability variable have a positive and significant effect on firm value and sales growth variabel have a positive and insignificant effect on firm value. The result with the simultaneous test indicate that the funding decision, investment decision, profitability and sales growth simultaneously have a significant effec on firm value in mining sector companies listed in Indonesia Stock Exchange.
Proximate Composition and Antimicrobial Activity of Kefir Produced from Cow’s and Almond Milk
Authors:   Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia, Hew Jing , Shafie Siti ,   Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia, Sulaiman Nurshahira ,   Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang,Selangor, Malaysia
Published: August 2023

Fermented foods are an important diet component of people around the world. Kefir, or fermented milk, is popular worldwide due to its high nutritional value, with cow's milk being the common substrate for traditional kefir fermentation. However, the scarcity of animal-based milk in some countries, plus cultural, religious, and health reasons, have seen non-dairy milk kefir from almond milk gaining popularity among consumers globally. This study aimed to evaluate and compare the proximate composition and anti-microbial activity of kefir produced from 100% cow or 100% almond or an equal (1:1) mixture of both kinds of milk. This study used the AOAC 2000 method for the proximate analysis, while the agar well diffusion method examined the anti-microbial activity of the milk samples against Escherichia coli, Staphylococcus aureus, and Salmonella typhi. Results revealed that the three kefir samples showed significantly different (p<0.05) moisture, total dietary fiber, and fat contents and were within the CODEX acceptable range for kefir. All samples exhibited varying degrees of inhibition between the different pathogens. The diameters of the inhibition zone of the tested kefir samples were significantly different toward Salmonella typhi (p<0.05), with the mixture of almond and cow milk notably producing better inhibition towards all tested bacteria. The above-said milk mixture also gave a better overall nutrient profile (lower fat and higher fibre). While almond milk might be a suitable substrate for kefir, it was not effectively inhibitory for all bacteria. The overall results thus conveyed the promising use of almond and cow milk mixture as an alternative substrate for kefir fermentation, further supporting its potential use as a probiotics source.
Green Synthesis of Silver Nanoparticles Using Leaves of Chromolaena odorata and its Antioxidant Activity
Authors:   Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Malaysia, Hasyim Siti , John Angelle ,   Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Malaysia
Published: August 2023

Harmful chemical waste is a serious problem being faced during the synthesis of nanoparticles due to the usage of hazardous chemicals. Synthesis of silver nanoparticles using aqueous extract of the leaves of C. odorata is cheap and environmentally friendly. This study reports the synthesis of silver nanoparticles (AgNPs) using C. odorata aqueous extract as reducing agent. The leaves of C. odorata was extracted by using cold maceration technique. The phytochemicals screening of leaves was done and positive results was showed for the presence of flavonoids, tannins, saponins, and phenolics in the leaves extract of C. odorata. The synthesized C. odorata extract mediated AgNPs was characterized using several techniques including UV-Visible spectroscopy and Field Emission Scanning Electron Microscopy (FESEM). The reduction of pure Ag (I) ions to Ag (0) was monitored using UV-Vis every one hour after 24 hours up to 28 hours and it showed an absorption band at 430-450 nm. Field emission scanning electron microscopy (FESEM) was utilized to determine its particle size and the average particle size obtained was 27.3 nm. The silver nanoparticles (AgNPs) produced by using C. odorata leaves aqueous extract was determined for its antioxidant activity by using DPPH free radical scavenging assay. The IC50 value obtained was 277.29 mg/ml. Based on the results obtained, it indicates that the silver nanoparticles (AgNPs) produced using C. odorata leaves aqueous extract possessed antioxidant activity that can scavenge free radicals.
Physical and Organoleptic Properties of Freeze-dried Local Beans and Salak Yogurt Powder
Authors:   Center of Excellent (CoE) on Health and Disaster Emergency (HADE) Center, Health Polytechnic of Tasikma-laya (Poltekkes Kemenkes Tasikmalaya), Radiati Ani ,   Department of Nutrition, Health Polytechnic of Tasikmalaya (Poltekkes Kemenkes Tasikmalaya), Nuraeni Irma ,   Department of Nutrition, Health Polytechnic of Tasikmalaya (Poltekkes Kemenkes Tasikmalaya)
Published: August 2023

Yogurt is one of the most popular fermented dairy products worldwide, with huge consumer acceptance due to its health benefits. While its shelf life is still relatively low, freeze-drying could extend the shelf life of yogurt. Other non-milk raw materials that can be an alternative substrate in yogurt are local Indonesian beans, namely Mung bean and Garut red bean. Additionally, yogurt can be added to the fiber- and carbohydrate-rich Manonjaya salak flour to produce a synbiotic product. Hence, this study aimed to produce yogurt powder comprising local nuts and Manonjaya salak through a freeze-drying process, which physical properties are organoleptically acceptable and meet Indonesian standards. In this study, the yogurt powder comprising the local Garut red- and Mung beans mixed with Manonjaya salak flour was compared to fresh yogurt as the control, plus yogurt powders from milk and nuts, as well as synbiotic yogurt powder from nuts, and Manonjaya salak flour. The physical properties of the resultant yogurt were tested for pH, %brix, moisture content, and organoleptic properties with hedonic testing. The findings revealed that the freeze-dried yogurt powder comprising Garut red- and Mung beans mixed with Manonjaya salak flour exhibited acceptable water content (10.39) with a 5.57 %brix and a final pH of 5.0, and was organoleptically acceptable by panelists. The physical and organoleptic properties of the Garut red-, mung beans, and Manonjaya salak flour yogurt power met the Indonesian national standards.
Morphological and Genetic Analysis of Momordica cochinchinensis (Lour.) Spreng. (Gac) from Different Accessions in Malaysia
Authors:   Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia, Khairi Nurin , Othman Halimaton ,   Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia
Published: August 2023

Momordica cochinchinensis or gac fruit is a 'superfruit' that is well-known in Vietnam. Gac is an orange fruit that is ovoid in shape and has a soft spiny texture. In Malaysia, gac fruit is a new and less known plant. This study aimed to characterize gac fruit using morphological analysis involving both vegetative and reproductive parts and to characterize the genetic diversity in gac fruit by using Inter-simple sequence repeat (ISSR) analysis. Four different gac accessions were collected from different areas (Kota Damansara (Selangor), Melaka Tengah (Melaka), Hulu Langat (Selangor) and Kuantan (Pahang)) were cultivated under tropical conditions in Kuantan, Pahang. The gac accessions showed differences in morphological characters. Generally, the gac fruits were reddish-orange in colour, the leaf was dark green on the adaxial part and light green on the abaxial part, and the female and male flower was light yellow and white in color. The fruit weight ranged from 193.72 g (GD) to 334.70 g (GH) with varied shapes and spike density. DNA extraction was following the CTAB method. All 30 primers showed high levels of polymorphism (83%) and the polymorphism information content (PIC) with the mean of 0.48.  Nei's genetic distance coefficient ranged between 0.27 and 0.6 with the mean value of 0.41. Dendrogram based on UPGMA analysis grouped the four gac accessions into two main groups. Cluster I consisted of accession GD, GM and GH while cluster II consisted of only GX. Results from both morphological and molecular analysis showed genetic diversities in all four gac fruits studied.
Increase in Serum Ferritin Level as a Marker of Disease Activity in Pediatric Sys-temic Lupus Erythematosus (pSLE) Patients
Authors:   Allergy-Immunology Division, Pediatric Departement, Faculty of Medicine Universitas Brawijaya, Malang 65145, Indonesia, Wulandari Desy , Barlianto Wisnu ,   Allergy-Immunology Division, Pediatric Departement, Faculty of Medicine Universitas Brawijaya, Malang 65145, Indonesia, Nugroho Susanto ,   Hematology-Oncology Division, Pediatric Departement, Faculty of Medicine Universitas Brawijaya, Malang 65145, Indonesia, Sari Tita ,   Pediatric Departement, Faculty of Medicine Universitas Brawijaya, Malang 65145, Indonesia,   dr. Saiful Anwar Hospital,Malang 65112,Indonesia
Published: August 2023

Ferritin is an acute-phase reactant that is elevated in autoimmune disorders, including systemic lupus erythematosus (SLE). However, their correlation with disease activity scores has not been confirmed. Pandemic Covid-19 makes children visitation to hospital to get the treatment of SLE were delayed. This study aimed to evaluate correlation between serum ferritin and disease activity and its role in screening for flare in pediatric SLE (pSLE) patients during pandemic Covid-19. This is a cross-sectional study conducted in Saiful Anwar General Hospital Malang. Sampling was carried out sequentially on pediatric patients who met the criteria for Systemic Lupus International Collaborating Clinics (SLICC) and were recorded between July 2021-May 2022. All patients were interviewed and assessed for disease activity using SLE Disease Activity Index 2000 (SLEDAI-2k). A score <4 was categorized as inactive disease. Biochemical, serological tests including markers of disease activity and ferritin level were measured by standard laboratory procedure. Comparison, correlation and ROC curve analyses were performed with SPSS software. There were 38 females pSLE participated in this study. The mean age of the patients were 12.6 ± 3.02 years. Serum ferritin significantly higher in active disease compared to inactive disease 84.50 ng/mL (68.00-151.75 ng/mL) ng/mL and 815.00 ng/mL (451.25-1570.00 ng/mL), a value of p<0.05 was determined to be statistically significant. A significant correlation was found between serum ferritin with SLEDAI 2K (r = 0.890, p = 0.000). Correlation was also found between serum ferritin and IgM anti-double stranded-DNA (r = 0.325, p = 0.046), but not with other laboratory and serological parameters. In ROC curve analysis, we found that Area Under The Curve (AUC) 0.989, 95%CI 0.964-1.014, p value 0,000, with cut off value 297.50 with sensitivity 85% and specificity 94.4%. Ferritin was increased in active disease   as compared to inactive disease and correlated with SLEDAI score and IgM-dsDNA. Thus, ferritin may be potential as an affordable and available marker of disease activity in pSLE during pandemic Covid-19.
The Genetic Organisation and Control of Putative Dehalogenase Gene Expression in Bacillus megaterium WSH-002
Authors:   Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM, Johor Bahru, Malaysia, Zulkarnain Luqman , Huyop Fahrul ,   Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM, Johor Bahru, Malaysia
Published: August 2023

Dehalogenase-producing bacterium has been extensively studied due to their ability to reduce pollution in the environment. A previous study reported that Bacillus megaterium WSH-002 contains a putative haloacid dehalogenase type II gene, therefore, the presence of other genes associated with the dehalogenase regulatory gene function and uptake of halogenated compounds are expected. In the Bacillus megaterium WSH-002 whole genome, type II dehalogenase (DehWSH002) and two other genes related to dehalogenase regulatory and haloacid uptake genes were identified suggesting its ability to control the expression of putative dehalogenase(s) and the uptake of halogenated compounds into the cells. The phylogenetic analysis showed that DehWSH002 shared common features with DehLBHS1 of Bacillus megaterium strain BHS1 and Had protein of Bacillus megaterium strain ATCC12872/QMB1551. The study concluded that the genome of Bacillus megaterium WSH-002 contains a dehalogenase gene designated as dehWSH002 that is useful for biodegradation. In addition, further investigation of the adjacent genes suggested the presence of dehalogenase regulatory gene (dehR) and an uptake gene (dehP) in a single genetic organisation.
Em busca de um padrão de subalternidade de populações negras no oeste paulista no pós-abolição
Authors: Truzzi Oswaldo , Palma Rogerio da , Monsma Karl
Published: August 2023

As duas décadas seguintes ao pós-abolição configuram-se como um momento chave para se observarem elementos que indicam a continuidade ou a ressignificação da subalternidade socioeconômica da população negra. Após discutir os conceitos de raça, racismo, racismo estrutural e processos de racialização que irão produzir a subcidadania negra, o presente artigo busca ressaltar, a partir de um escopo variado de fontes, dimensões empíricas da subalternidade negra com base no estudo aprofundado de um município característico da economia cafeeira do oeste paulista.
A gestão empresarial das memórias sensíveis: poderes, sentidos e práticas em torno do Cais do Valongo no Rio de Janeiro
Authors: Guimarães Roberta Sampaio , Castro João Paulo Macedo
Published: August 2023

Neste artigo, analisamos os feixes de poder que possibilitaram a inscrição do sítio arqueológico Cais do Valongo como Patrimônio Mundial. Através de documentos, trabalho de campo e literatura especializada, destacamos três cenários: a incorporação de ativistas dos movimentos negros à administração pública no final dos anos 1970, a legitimação internacional das agendas afro-brasileiras pelo projeto A Rota do Escravo da Unesco e o incremento à indústria turística durante a operação urbana Porto Maravilha no início do século XXI. Argumentamos que a territorialização das memórias da escravidão foi impulsionada por uma gestão empresarial das identidades culturais, em que métodos e procedimentos técnicos impuseram-se como modelo de ação política. Desse modo,  concluímos que o discurso da identidade afro-brasileira se integrou às novas dinâmicas de acumulação do capital e de mercantilização cultural, com os sentidos e práticas em torno do cais agregando as lógicas do dever de memória e da regulação concorrencial.
Estrutura de sentimento e autobiografia em "O campo e a cidade"
Authors: Jackson Luiz Carlos , Rivetti Ugo , Pinheiro Dimitri
Published: August 2023

Aproveitando a efeméride dos cinquenta anos da publicação de O campo e a cidade, este artigo examina o livro de Raymond Williams sob dois aspectos principais. De um lado, pretendemos elucidar os usos e significados da noção “estrutura de sentimento”, que nesse trabalho organiza toda a argumentação, como uma espécie de operador analítico; de outro, discutimos as frequentes referências autobiográficas, que reforçam seu tom reflexivo e político.
A identidade material em A solidão de um quadrinho sem fim
Authors: Monteiro Clarissa Ferreira
Published: August 2023

Este artigo propõe explorar a construção da identidade na graphic novel autobiográfica A solidão de um quadrinho sem fim, de Adrian Tomine (2020a), a partir de uma reflexão sobre seu projeto gráfico. A obra é construída em um suporte que se assemelha a um sketchbook da marca Moleskine, apresentando uma nova camada de leitura motivada pela interação física com o produto e a exploração de sua espacialidade. O objetivo desta análise é explorar mais a fundo a construção da identidade por meio do uso de um produto, conforme propõe Floch (2000), considerando a relação que se estabelece entre a narrativa e o instrumento de trabalho do quadrinista, e as aproximações que o quadrinho promove entre enunciador-autor e enunciatário-leitor.
Tatjana (Tanja) Valjo Žanić (Karlovac, 27. lipnja 1934. – Karlovac, 5. rujna 2003.)
Authors: Mirilović Snježana
Published: August 2023

Uvod: Sustavno prikupljenih i objavljenih podataka o školovanju i radu medicinskih sestara u Karlovcu ima vrlo malo. Većinom su ti podaci sastavni dijelovi monografija zdravstvenih ustanova te do sada tri objavljena pregledna rada o povijesti sestrinstva u Karlovcu. U ovom radu učinjena je rekonstrukcija života, školovanja i rada medicinske sestre Tatjane Valjo Žanić koja pruža uvid u mogućnosti školovanja i djelokrug rada medicinskih sestara pedesetih i šezdesetih godina prošlog stoljeća.Metode: Temelj za izradu rada bili su dokumenti pohranjeni u pismohrani Opće bolnice Karlovac, osobni dokumenti Tatjane Valjo Žanić, sinova usmena svjedočanstva, svjedočanstva bivših učenica Medicinske škole Karlovac i suradnika.Rezultati: Tatjana Valjo Žanić završila je četiri razreda pučke škole i četiri razreda realne gimnazije u Karlovcu. Srednju medicinsku školu završila je u Splitu. Kao stipendistica Savjeta za narodno zdravlje i socijalnu politiku Narodne Republike Hrvatske, pohađala je postdiplomski studij za usavršavanje sestara pri Školi narodnog zdravlja Medicinskog fakulteta u Zagrebu. Bila je stipendistica jednogodišnjeg usavršavanja u Engleskoj. Cijeli radni vijek provela je u Karlovcu. Bila je glavna sestra dječjeg odjela, glavna sestra Doma narodnog zdravlja, voditeljica patronažne službe, glavna sestra Medicinskog centra i glavna sestra patronažne službe. Radila je kao nastavnik u Školi za medicinske sestre i bila je v. d. ravnateljica Škole za higijeničare. Tijekom rada pohađala je nekoliko programa trajnog usavršavanja.Zaključak: U promatranom razdoblju medicinskim sestrama bio je omogućen odlazak na stručna usavršavanja u domaće i inozemne zdravstvene ustanove. Tijekom tih edukacija bila im je isplaćivana plaća. Za rukovodeća radna mjesta raspisivani su javni natječaji s jasno definiranim uvjetima. Sustavno se pratio rad zaposlenika koji se evaluirao na godišnjoj razini. Ustanove su, sukladno rezultatima rada zaposlenika, omogućivale isplatu jednokratne novčane nagrade. Prema navodima medicinskih sestara možemo pretpostaviti da su krajem 60-ih godina prošlog stoljeća zdravstvene ustanove u Karlovcu otvarale malo novih radnih mjesta za medicinske sestre.
Nursing care and its impact on safety culture
Authors: Herak Ivana , Neuberg Marijana , Grgurović Denis
Published: August 2023

Introduction: The World Health Organization defines patient safety as “a framework of organised activities that creates cultures, processes, procedures, behaviours, technologies, and environments in health care”. Patients have a right to expect that every effort is made to ensure their safety as users of all health services. The healthcare system today is facing major challenges, including a lack of human resources, an excessive workload of healthcare professionals, a large number of complex cases, the use of new technologies, and many others. Patient safety is an important component of health care, and it depends on several factors, such as the safety culture, organisation policy, competencies of personnel, and the way care is provided. Safety culture recognises high-risk activities; it is defined as a no-blame culture, and it seeks solutions to problems through an interdisciplinary approach. Objective: To investigate patient safety culture from the perspective of nurses/nursing technicians and the association between nursing care and patient safety in health institutions through a systematic literature review.Methods: A descriptive method was used, a review of scientific and professional literature in the field of nursing care, patient safety culture, patient safety, and adverse events.Results: Results show that patient safety culture characteristics are correlated with nurses’/nursing technicians' intention to report errors. A stronger safety culture along with a developed patient safety competency was found to be significantly associated with a lower incidence of adverse events and surgical site infections, indicating that nurses' competence could reduce the occurrence of adverse events and improve patient safety culture.Conclusion: Improved patient outcomes are associated with a safety culture characterised by shared attitudes among healthcare providers about the importance of patient safety, loyalty, communication transparency, and shared trust in the efficacy of safety measures.
“God” in Augustine’s Confessions
Authors: van Oort Johannes
Published: August 2023

When reading through Augustine’s Confessions, one notices a striking variety of descriptions of God. The aim of this paper is to discern and – as far as possible – to interpret these various descriptions. Our main focus will be on pivotal texts from Books 1, 3, 5, 6 and 7. They document how much Manichaean views played a part in Augustine’s quest, and how closely this quest was linked to his ideas about evil. Briefly stated, Augustine’s search went from anthropomorphic-spatial thinking about God to corporeal/material-spatial and even panentheistic ideas and then (mainly under the inspiration of Neoplatonic philosophy, i.e., in all likelihood Plotinus’s Enneads) to a strictly spiritual and non-spatial understanding. But in all this, Manichaean ways of thought and even concepts remained present until the end. A final conclusion draws out the significance of this study for conceptualising the formation of God/gods in the Christian tradition as well as in other religious formations.
Under Caesar’s Sword
Authors: Eastman David L.
Published: August 2023

In 2019, Cambridge University Press published an edited volume entitled Under Caesar’s Sword, the product of a three-year study on contemporary Christian responses to persecution in various parts of the world. As part of the overall findings, the project directors noted three primary methods of response: (1) Survival strategies (trying to avoid the attention of the persecutors); (2) Association strategies (building relationships beyond their own communities in order to create a broader network of potential support); and (3) Confrontation strategies (directly challenging the persecutors through various means including martyrdom, which Christians accept as an act of resistance). These categories provide a useful heuristic tool for reevaluating the discourse in some early Christian texts, including the apocryphal acts of the apostles and other texts related to martyrdom. This article employs the insights from Under Caesar’s Sword to explore examples of all three strategies from the earliest Christian centuries. However, not all strategies were equally appreciated in that time. Because suffering came to be so closely linked to Christian identity, survival strategies were sometimes critiqued as evidence of a lack of faith.
Ireland and India between Home and the World
Authors: Chattopadhyay Arka
Published: August 2023

This article charts world-making and home-formation as two connectors between Irish and Indian literature on their way toward becoming world literature. Home and world are conceptualized as flows while the idea of the path is seen as a synthetic bridge between them. The first part examines how Irish literature becomes world literature by studying two temporal encounters between Irish and Indian writers, between W.B. Yeats and Rabindranath Tagore and between Colm Tóibín and Amit Chaudhuri. The second part shifts from temporality to spatiality in a discussion of global modernisms that reads Tagore’s 1922 Lipika text on the path in relation to T.S. Eliot’s modernist imagination of tradition and the individual talent. The two parts of the article coalesce around the triad of home, world and path by envisaging the turn of world literature with a renewed focus on the universal and the ontological oneness of literature.
The War at Home: Antiwar Protests and Congressional Voting, 1965 to 1973
Authors: McAdam Doug , Su Yang
Published: August 2023

Time-series analysis is used to assess the relationship between antiwar protests and congressional voting on war-related roll calls during the Vietnam era. Using protest event data coded from The New York Times and counts of roll-call votes generated from congressional voting data, we test for three specific mechanisms: disruptive protest, signaling, and public opinion shift. Extreme forms of disruptive protest are hypothesized as having a direct positive effect on congressional voting. Lohmann's signaling model posits exactly the opposite relationship between protest and policy. Especially extreme protests are expected to have a negative effect on both the pace and pro-peace direction of congressional action. Conversely, large (and more moderate) protests are expected to have a positive effect on House and Senate voting. The final mechanism, public opinion shift, depicts the relationship as indirect, with protest encouraging public opinion change, which, in turn, encourages increasingly favorable congressional voting. The results are somewhat mixed with respect to all three mechanisms, but suggest an interesting general pattern. The most extreme or threatening forms of protest (e.g., those featuring violence by demonstrators and/or property damage) simultaneously increase pro-peace voting while depressing the overall pace of congressional action. The reverse is true for more persuasive forms of protest (e.g., large demonstrations), which appear to increase the pace of voting while depressing the likelihood of pro-peace outcomes.
The Shadow of Exploitation in Weber's Class Analysis
Authors: Wright Erik Olin
Published: August 2023

This analysis has two basic objectives: First, to understand as precisely as possible the inner structure of Weber's concept of class, its similarities and differences from Marx's concept, and its relationship to the problem of exploitation; second, to use this interrogation of Weber's work to defend the importance of the concept of exploitation for sociological theory. To understand the foundations of Weber's class analysis one must look beyond his most synoptic treatments of class in Economy and Society and see how his concept of class is intimately linked to his investigations of the broad problem of rationalization in modern society. Class, in these terms, is the way economic power is distributed when economic action is organized to the greatest degree in an instrumentally-rational manner. The problem of exploitation—the extraction of labor effort from workers—is treated, in this framework, primarily as a problem of technical efficiency and economic rationality in creating work incentives and effective discipline. This conceptualization leads to a relatively impoverished understanding of the nature of antagonistic interests generated by class relations.
Cohort Effects on Suicide Rates: International Variations
Authors: Stockard Jean , O'Brien Robert M.
Published: August 2023

Recently, the long observed pattern of a monotonic increase in suicide with age has shifted, often dramatically, because more recent birth cohorts have exhibited much higher suicide rates at younger ages than earlier cohorts have. These changes, however, did not occur in all countries. We examine cohort variations in suicide rates in 14 modern, western societies using an extension of the age-period-cohort characteristic model that incorporates hierarchical linear modeling. Results support a general Durkheimian perspective. Birth cohorts experiencing relatively less social integration and regulation, as measured by higher rates of nonmarital births and larger relative cohort size, have higher suicide rates than other cohorts. Societies that provide alternative sources of social integration and regulation, as through collectivist institutions or through greater support for families and children, moderate this tendency. On the other hand, when societies experience rapid social change, the relationship between decreased social integration and regulation and increased suicide rates is stronger, especially for males. These results have implications for stemming the increased suicide rates for youth observed in many contemporary societies.
Social Integration, Imitation, and the Geographic Patterning of Suicide
Authors: Baller Robert D. , Richardson Kelly K.
Published: August 2023

One of sociology's defining debates centers on explanations of the geographic patterning of suicide. This classic debate is revisited using techniques of spatial analysis and data for two geographies: late nineteenth-century French departments, and late twentieth-century U.S. counties. Results of the French analysis contradict Durkheim's claim that “imitation” plays no role in shaping the geographic patterning of suicide. Suicide rates for northern and southern French departments cluster geographically even when the clustering of multiple dimensions of social integration is controlled. These findings are replicated in a contemporary analysis of nonwestern U.S. counties. Results for the American West, however, support the Durkheimian view that suicide clusters in geographic space only because important structural predictors of suicide, including measures of social integration, do so as well. These discrepant findings are reconciled and it is concluded that the geographic patterning of suicide is shaped by both social integration and imitation.
Including Mechanisms in Our Models of Ascriptive Inequality
Authors: Reskin Barbara F.
Published: August 2023

Sociologists’ principal contribution to our understanding of ascriptive inequality has been to document race and sex disparities. We have made little headway, however, in explaining these disparities because most research has sought to explain variation across ascriptive groups in more or less desirable outcomes in terms of allocators’ motives. This approach has been inconclusive because motive-based theories cannot be empirically tested. Our reliance on individual-level data and the balkanization of research on ascriptive inequality into separate specialties for groups defined by different ascriptive characteristics have contributed to our explanatory stalemate. Explanation requires including mechanisms in our models—the specific processes that link groups’ ascribed characteristics to variable outcomes such as earnings. I discuss mechanisms that contribute to variation in ascriptive inequality at four levels of analysis—intrapsychic, interpersonal, societal, and organizational. Redirecting our attention from motives to mechanisms is essential for understanding inequality and—equally important—for contributing meaningfully to social policies that will promote social equality.