bluuebunny/crossref_metadata_2025 huggingface dataset:
Equity dimensions in initiatives promoting urban health and wellbeing in east and southern Africa
Authors: Loewenson Rene , Mhlanga Gibson , Gotto Danny , Chayikosa Sam , Goma Fastone , Walyaro Constance
Published: April 2023

Urbanisation in east and southern Africa (ESA) has brought opportunity and wealth together with multiple dimensions of deprivation. Less well documented in published literature on the ESA region are features of urban practice that promote health equity. This work thus aimed to explore features of urban initiatives aimed at improving health and wellbeing in ESA countries and their contribution to different dimensions of health equity. A thematic analysis was implemented on evidence gathered from 52 documents from online searches and 10 case studies from Harare, Kampala, Lusaka, and Nairobi. Most of the initiatives found focused on social determinants affecting low income communities, particularly water, sanitation, waste management, food security and working and environmental conditions, arising from longstanding urban inequalities and from recent climate and economic challenges. The interventions contributed to changes in social and material conditions and system outcomes. Fewer reported on health status, nutrition, and distributional outcomes. The interventions reported facing contextual, socio-political, institutional, and resource challenges. Various enablers contributed to positive outcomes and helped to address challenges. They included investments in leadership and collective organisation; bringing multiple forms of evidence to planning, including from participatory assessment; building co-design and collaboration across multiple sectors, actors and disciplines; and having credible brokers and processes to catalyse and sustain change. Various forms of mapping and participatory assessment exposed often undocumented shortfalls in conditions affecting health, raising attention to related rights and duties to promote recognitional equity. Investment in social participation, organisation and capacities across the initiatives showed participatory equity to be a consistent feature of promising practice, with both participatory and recognitional equity acting as levers for other dimensions of equity. There was less evidence of distributional, structural and intergenerational equity. However, a focus on low income communities, links made between social, economic and ecological benefit, and investment in women and young people and in urban biodiversity indicated a potential for gains in these areas. The paper discusses learning on local process and design features to strengthen to promote these different dimensions of equity, and issues to address beyond the local level to support such equity-oriented urban initiatives.
Peer pressure and adolescent mobile social media addiction: Moderation analysis of self-esteem and self-concept clarity
Authors: Xu Xiaopan , Han Wanqu , Liu Qingqi
Published: April 2023

Background

Social media addiction has increasingly been a critical social problem. We explored the association between peer pressure on mobile phone use and adolescent mobile social media addiction and tested whether self-esteem and self-concept clarity could buffer the effect of peer pressure.

Methods

830 adolescents (Mage = 14.480, SDage = 1.789) participated in our anonymous cross-sectional questionnaire study.

Results

The results showed that peer pressure significantly predicted adolescent mobile social media addiction. Self-esteem moderated the effect of peer pressure on mobile social media addiction in that peer pressure had a weaker effect for adolescents with higher self-esteem. Self-concept clarity moderated the effect of peer pressure on mobile social media addiction in that peer pressure had a weaker effect for adolescents with higher self-esteem. The two moderators also interact in that the moderation of self-esteem was stronger for adolescents with higher self-concept clarity and the moderation of self-concept clarity for adolescents with higher self-esteem.

Conclusion

The results highlight the critical role of self-esteem and self-concept clarity in buffering the impact of peer pressure on mobile social media addiction. The findings promote a better understanding of how to buffer the undesirable effect of peer pressure and reduce the risk of mobile social media addiction among adolescents.
Exploring restaurant and customer needs, barriers, interests, and food choices induced by the COVID-19 pandemic in Tarragona Province (Catalonia, Spain): A cross-sectional study
Authors: Besora-Moreno Maria , Queral Judit , Torres Silvia , Llauradó Elisabet , Tarro Lucia , Solà Rosa
Published: April 2023

Background

COVID-19 has harmed restaurants, but customer preferences remain unknown. This study aims to determine the needs, barriers, interests, and food choice changes in restaurants and customers before and during the COVID-19 pandemic in Tarragona Province (Spain).

Methods

An observational cross-sectional study conducted in spring 2021 collected Mediterranean offerings, food safety, and hygiene information about the pandemic through online surveys and focus group interviews with restaurateurs and customers about the changes in their needs and new barriers.

Results

Fifty-one restaurateurs (44 survey, 7 focus group) and 138 customers (132 survey, 6 focus group) were included. In relation to the economic, emotional, and uncertainty restaurateurs’ barriers detected, they implemented measures to tackle it: buy less and more often, reduce restaurant staff and reduce the restaurants offer, among others. Some customers reported changes in their restaurant orders, specifically increasing their takeaway orders. The Mediterranean diet offer (AMed criteria) remained without noticeable changes in any of the criteria. After lockdown, compared to before lockdown, restaurateurs increased their takeaway offerings by 34.1% (p < 0.001) and their use of digital menus by 27.3% (p < 0.001) because of customer demand. The use of local products in the menus remained high. The cleaning and disinfection tasks increased by 21.1% (p = 0.022), and the use of hydroalcoholic solutions increased by 13.7% (p = 0.031).

Conclusion

In restaurants, the first COVID-19 lockdown increased takeaway orders, sanitation, and digital communication. This study provides valuable information for adapting gastronomic offerings during challenging situations.
Humanistic health of the physical living environment: The equity of property inheritance in China
Authors: Shu Mengrong , Li Jinxin , Wu Yuhan , Chen Kaida , Ding Shuhui
Published: April 2023

Equity in the inheritance culture of family property is an important component of humanistic health in modern living environments. The inheritance of property under Chinese traditional family culture is the material basis for the continuation of family and clan. This study demonstrates the equity component embedded in traditional family inheritance culture and further studies of the healthy human settlements environment. Based on the theory of “equal share for all sons” in ancient China and the “equity” and “justice” that are of modern significance, this paper analyzes the family division culture of individual traditional housing and the corresponding impact indices of family division equity. Taking Renhe Village, a typical local residential building of the middle and late Qing Dynasty as the research object, this study built a spatial syntax data model and 3D simulation technology for the simulation analysis of space and climate. The results show that Renhe Village meets the requirements of the equity evaluation system of housing property rights distribution in terms of the natural unit indicator (quantity, lighting, ventilation) and the overall spatial indicator (privacy, centrality, convenience). In other words, equity does not mean an absolute average share, but an equity culture formed after six evaluation indices under the subdivision of two indicators are balanced. Based on the above, an equity system model of housing property rights distribution was established, and the weight of the ancients' attention to the housing distribution standard was explored. It is further found that the ancients attached more importance to light among the natural unit indicators, and attached the most importance to centrality in the overall spatial indicators. These findings provide new ideas for understanding the equity of property inheritance under Chinese traditional family culture. They also provide quantifiable criteria for the distribution of modern rural housing and social security housing, and ultimately provide a reference for the humanistic public health of the modern living environment.
Racial disparities in access to health care infrastructure across US counties: A geographic information systems analysis
Authors: Guo Jingchuan , Dickson Sean , Berenbrok Lucas A. , Tang Shangbin , Essien Utibe R. , Hernandez Inmaculada
Published: April 2023

Infrastructure system in the U.S. have been shown to be linked to social and health inequities. We calculated driving distance to the closest health care facility for a representative sample of the U.S. population using ArcGIS Network Analyst and a national transportation dataset, and identified areas where Black residents have a longer driving distance to the closest facility than White residents. Our data demonstrated that racial disparities in access to health care facilities presented large geographic variation. Counties with significant racial disparities were concentrated in the Southeast and did not correspond to counties with a greater proportion of the overall population >5 miles to the closest facility, which were concentrated in the Midwest. This geographic variation demonstrates the need to adopt a spatially explicit data driven approach in the design of equitable health care facility establishment that address the specific limitations of the local infrastructure.
Mental health during the COVID-19 pandemic: Stress and strain profiles in the German population
Authors: Nin Vincent M. E. L. , Willmund Gerd-Dieter , Jungmann Stefanie M. , Asmundson Gordon J. G. , Piefke Martina
Published: April 2023

Clinical observations indicate that people frequently display stress-related behavior during the COVID-19 pandemic. Although numerous studies have been published concerning pandemic-related psychological distress, systematic data on the interrelationships between stress sensitivity, personality, and behavioral characteristics of people are still lacking. In the present cross-sectional online survey study, we applied a German version of the COVID Stress Scales (CSS) and standard psychological questionnaires to systematically identify the complex interplay between stress sensitivity, gender, and personality in the modulation of quality of life and mental health in the German population (N = 1774; age ≥ 16 years). A CSS-based cluster analysis revealed two clusters characterized by higher and lower stress levels. Study participants in each cluster differed significantly with respect to neuroticism, extraversion, agreeableness, quality of life, depression, and anxiety. Females were significantly overrepresented in the higher stress cluster, while there was an overrepresentation of males in the lower stress cluster. Neuroticism was identified as a risk factor and extraversion as a protective factor for enhanced pandemic-related stress responses. For the first time our data show a taxonomy of factors, which modulate pandemic-related stress sensitivity and warrant consideration as key indicators of quality of life and psychological distress during the COVID-19 pandemic. We suggest that our data may advise governmental regulation of pandemic-related public health measures, to optimize quality of life and psychological health in different groups of the population.
Childhood adversity, emergent psychopathology, and adolescent-to-parent violence: Process mining trajectories from police and health service administrative data
Authors: Peck Allison , Hutchinson Marie , Provost Steve
Published: April 2023

Aim

To discover developmental risk trajectories for emerging mental health problems among a sample of adolescent family violence offenders to inform service delivery focused on early preventative interventions with children and their families.

Design

A retrospective case-series design employing data linkage.

Setting

An Australian regional location.

Participants

Adolescents (born between 1994 and 2006) issued a legal action by the NSW Police Force for an adolescent-to-parent family violence offense (n = 775).

Procedure

Discrete routinely collected episode data in police and health service electronic records for children, and police data for parents, were linked and transformed into longitudinal person-based records from birth to 19 years to identify trajectories for mental health problems.

Results

Sixty-three percent (n = 489) of adolescents had contact with a mental health service before age 19. The majority of these adolescents received a diagnosis for a stress or anxiety disorder (n = 200). Trajectory analysis found childhood exposure to parental intimate partner violence and parental drug and/or alcohol use were dominant events in the pathway to receiving a mental health diagnosis. Being a victim of a sexual offense was found to increase the odds of adolescents having a diagnosis for each of the main mental health categories (with the exception of drug or alcohol disorders).

Conclusions

Pathways to mental health problems were characterized by inter-related adverse childhood events and poly-victimization for many adolescents. Early identification of at-risk children must be a continued focus of child health services in order to reduce and identify early emerging mental health problems.
Postural control exercise without using the upper limbs improves activities of daily living in patients with stroke
Authors: Kamijo Akio , Furihata Chisato , Kimura Yuki , Furuhata Isamu , Ohtani Takeshi , Miyajima Takeshi
Published: April 2023

Introduction

Stroke is one of the most common neurological disorders worldwide. Stroke survivors have restricted activities of daily living (ADL) and lower functional independence measures (FIM) after disease onset. Recovery of postural control abilities in patients with stroke is one of the most important therapeutic goals. In this study, we examined the differences in the FIM motor items between groups that performed postural control exercises with the upper limb and those that performed postural control exercises without the upper limb.

Methods

The medical records of patients with stroke admitted and discharged from the Recovery Rehabilitation Unit at Azumino Red Cross Hospital between 2016 and 2018 were reviewed. We retrospectively investigated the relationships between postural control exercises with or without upper limbs, FIM motor items at admission and discharge, and percentage of gait acquisition at discharge.

Results and Discussion

Among the thirteen FIM motor items, nine (bathing, dressing the upper body, dressing the lower body, toileting, transfers [bed, chair, and wheelchair], transfers [toilet], transfers [tub or shower], locomotion, and climbing of stairs) were significantly different between the two groups (those who performed postural control exercises with the upper limb and those who performed postural control exercises without the upper limb). Patients with stroke who performed postural control exercises without the upper limbs showed a higher percentage of gait acquisition. Touch contact during quiet standing reduces body sway and the associated fluctuations. However, continual practice of postural control with a small degree of body sway for a long period after a stroke would result in decreased pressure on the sole. This may hinder postural control relearning. Touch contact also reduces anticipatory postural adjustment, which may limit the improvement in balance ability during physical exercise. Postural control exercises without the upper limbs improve postural control ability and may be beneficial from a long-term perspective.
Should an R&D manager refer to distant technical fields? The effectiveness of new combinations with knowledge from different technical fields through the quantitative analysis of patent data related to NetZero
Authors: Hirose Masayuki
Published: April 2023

This study showcases a technique to categorize NetZero-related patent applications into three technical fields according to the degree of proximity between claimed inventions and cited inventions by comparing technological classifications between the patent applications and cited applications thereof. In this technique, the author first describes the existing methods used in previous studies. The technique proposed in this article is different from those of previous studies in that it is characterized by comparing the technical fields of not only the primary classification but also the subsequent classifications. This is made possible by using two patent classifications without having a specific classification corresponding to the middle hierarchy in between, rather than using three patent classifications with different hierarchies. This technique reduces the possibility that two applications, even if they are the same in their subsequent classification, will be judged as applications in different technical fields because they are in different classes in the primary classification. Using the proposed technique, the author examined the impact on the subsequent patent application of NetZero-related patent applications filed in Japan. As a result of the analysis, the author found that approximately 33% of subject applications, whose technical field differs from the backward citations when comparing the primary classification only, match one of the subsequent classifications when comparing them in consideration of the subsequent classifications as well. The author then found that these 33% of subject applications had a greater impact on subsequent patent applications than the remaining applications.
The continuum of wood-induced channel bifurcations
Authors: Marshall Anna , Wohl Ellen
Published: April 2023

Accumulations of wood in rivers can alter three-dimensional connectivity and facilitate channel bifurcations. Bifurcations divide the flow of water and sediment into secondary channels and are a key component of anastomosing rivers. While past studies illustrate the basic scenarios in which bifurcations can occur in anastomosing rivers, understanding of the mechanisms of bifurcations remains limited. We evaluate wood-induced bifurcations across thirteen anastomosing reaches in nine different streams and rivers in the U.S. Rocky Mountains to address conditions that favor different bifurcation types. We hypothesize that (1) wood-induced bifurcations exist as a continuum of different patterns in anastomosing rivers and (2) the position of a river segment along this continuum correlates with the ratio of erosive force to erosional resistance (F/R). We use field data to quantify F/R and compare varying F/R to bifurcation types across sites. Our results support these hypotheses and suggest that bifurcation types exist as a continuum based on F/R. At higher values of F/R, more channel avulsion is occurring and predominantly lateral bifurcations form. At lower values of F/R, banks are more resistant to erosive forces and wood-induced bifurcations are transitional or longitudinal with limited lateral extent. The relationship between F/R and bifurcation types is not linear, but it is progressive. Given the geomorphic and ecological functions associated with large wood and wood-induced channel bifurcations, it becomes important to understand the conditions under which wood accumulations can facilitate different types of bifurcations and the processes involved in these bifurcations. This understanding can inform river corridor restoration designed to enhance the formation of secondary channels, increase lateral and vertical connectivity, and promote an anastomosing planform.
Longitudinal monitoring of workloads in women's division I (DI) collegiate basketball across four training periods
Authors: Towner Randy , Larson Abigail , Gao Yong , Ransdell Lynda B.
Published: April 2023

Women's collegiate basketball is a fast-growing, dynamic sport that spans 8 or more months, with athletes competing in 30 + games in a season. The aim of this study was to quantify and profile the external load of practices and games during a Power-5 DI Women's Collegiate Basketball season. Specifically, Average PlayerLoad (PL), PlayerLoad per minute (PL*min−1), High Inertial Movement Analysis (High-IMA), and Jumps were quantified using Catapult Openfield software during four distinct training periods of the year: 8-hour preseason, 20-hour preseason, non-conference, and conference game play. Weekly variations and acute to chronic workload ratios (ACWR) were also examined. Eleven subjects participated in daily external load monitoring during practice and games via Catapult's ClearSky T6 inertial measurement units (IMU). Averages, standard deviations, and confidence intervals were calculated for training period comparisons, and Cohen's d was calculated as a measure of effect size. Findings include normative values to provide context for the demands experienced across an entire season. PL was significantly higher during non-conference play than during any of the other three training periods (p < 0.05). Descriptive data enumerate percent change and ACRW variations throughout the season. These data can be used to describe the physical demands across a season and provide physical profile guidelines for coaches.
Transcatheter arterial embolization of cystic artery bleeding
Authors: Kim Hyo-Cheol , Jeong Yun Soo , Han Kichang , Kim Gyoung Min
Published: April 2023

Purpose

The purpose of this study is to assess the safety and clinical outcomes of transcatheter arterial embolization (TAE) via the cystic artery for treating patients with bleeding from the cystic artery.

Materials and Methods

This retrospective study included 20 patients who underwent TAE via the cystic artery between January 2010 and May 2022. Radiological images and clinical data were reviewed to evaluate causes of bleeding, procedure-related complications, and clinical outcomes. Technical success was defined as the disappearance of contrast media extravasation or pseudoaneurysm, as demonstrated on completion angiography. Clinical success was defined as discharge from the hospital without any bleeding-related issues.

Results

Hemorrhagic cholecystitis (n = 10) was the most common cause of bleeding, followed by iatrogenic (n = 4), duodenal ulcer (n = 3), tumor (n = 2), and trauma (n = 1). Technical success was achieved in all cases, and clinical success was achieved in 70% (n = 14) of patients. Three patients developed ischemic cholecystitis as a complication. Six patients with clinical failure died within 45 days after embolization.

Conclusion

TAE through the cystic artery has a high technical success rate in treating cystic artery bleeding, but clinical failure remains a common occurrence due to concurrent medical conditions and the development of ischemic cholecystitis.
Global research on cysticercosis and neurocysticercosis: A bibliometric analysis
Authors: Gonzalez-Alcaide Gregorio , Sosa Nestor , Shevy Laura , Belinchon-Romero Isabel , Ramos-Rincon Jose-Manuel
Published: April 2023

Background

Cysticercosis is a parasitic infection caused by the larval stageTaenia solium. As a neglected tropical disease that is also difficult to diagnose, cysticercosis constitutes an important public health and research challenge. To characterize the development of research on cysticercosis and neurocysticercosis, considering the level of scientific evidence provided and the contribution of different countries to research, according to their endemic nature and their income level.

Methods

Indexed publications on cysticercosis and neurocysticercosis were retrieved from the MEDLINE database, and the evolution of scientific production and the topic areas addressed in the body of research were analyzed.

Results

A total of 7,860 papers published between 1928 and 2021 were analyzed. The volume of annual publications increased over time, standing at over 200 documents/year since 2010. Case studies constitute the main study design (27.4% of the documents with available information,n= 2,155), with fewer studies that provide the highest levels of scientific evidence, such as clinical studies (1.9%,n= 149) or systematic reviews (0.8%,n= 63). The most productive journals belong to the Parasitology and Tropical Medicine categories. Although the USA is the most productive country (n= 2,292), countries whereTenia soliumis endemic, such as India (n= 1,749), Brazil (n= 941) and Peru (n= 898) also stand out, as does Mexico (n= 1,414). However, other endemic countries in Latin America and sub-Saharan Africa show little participation in the research. The level of international collaboration by country is very uneven, with some countries presenting very low values, such as India (9.9% of documents in international collaboration) or Brazil (18.7%); while there is evidence of intense international collaboration in countries like Peru (91.3%), Tanzania (88.2%) or Kenya (93.1%). Research output has coalesced in three thematic clusters: basic research in animals; parasitism, animal health, and zoonoses; and the diagnosis and therapeutic approach in diseases associated with cysticercosis and neurocysticercosis.

Conclusions

The generation of knowledge on cysticercosis presents different features from other areas of research, such as the outstanding contribution of only some endemic countries; and the relevance of comprehensive approaches to research (animal and human health). Studies that provide higher levels of scientific evidence should be promoted, as should research in endemic areas.
Statistical and Water Management Assessment of the Impact of Climate Change in the Reservoir Basin of the Volga–Kama Cascade on the Environmental Safety of the Lower Volga Ecosystem
Authors: Buber Alexander , Bolgov Mikhail , Buber Vladimir
Published: April 2023

When managing water resources in order to provide water to consumers, a number of consequences arise related to the violation of the hydrological regime due to the regulation of flow by reservoirs. The second factor is possible climate change. These changes can negatively (or positively) affect the functioning of aquatic ecosystems. To reduce the impact on the environment, it is necessary to determine the nature and indicators of changes in the hydrological regime, calculate quantitative estimates of these indicators and ranges of acceptable values, and develop release rules that ensure compliance with these ranges with a given probability. To manage the water resources of the Volga and Kama Rivers, the main ecological task is to flood the floodplain meadows, to maintain the conditions of natural reproduction of fish on the Lower Volga, including the Volga River delta and the Volga–Akhtuba floodplain. In addition, it is necessary to meet with sufficient reliability the requirements of energy in the summer–autumn and winter low-water periods and water transport during the navigation period. The task of optimal management is to find such solutions in years of different water content that ensure the well-being of the main water users with a given probability and do not disturb the Lower Volga ecosystem. This article presents the research of the water resources state of the water resource system of the Volga and Kama river basins. A statistical analysis of the hydrological series of the observed inflow for 1916–2020 was performed, and the inflow change point (1979) was found by the Bayesian method of estimation. A statistically significant difference between the average inflow values of two series (1916–1978, 1979–2020) was proved using a two-sample Student’s test. The seasonal parameters of the reliability curves were calculated based on the three-parameter Kritsky and Menkel distribution. For these two series, water resource optimization calculations (using Excel Solver) were performed, and the reliability of fulfilling the requirements of water users was determined; for the series 1916–1978, an alternative solution was found in favor of fisheries, and an analysis of the results was also performed. The methodology used in the research allows finding trade-off solutions in the favor of different water users (ecology, agriculture and fisheries, water supply, hydropower, navigation, etc.) and is based on the use of multi-criteria optimization methods and the trade-offs theory. As a result of the research, new knowledge was obtained about the hydrological situation in the basin of the Volga–Kama reservoir cascade in connection with climate change.
Asynchronous Track-to-Track Association Based on Pseudo Nearest Neighbor Distance for Distributed Networked Radar System
Authors: Chen Shuangyou , Zhang Hongwei , Ma Juntao , Xie Hui
Published: April 2023

In radar network systems, target tracks reported from different radars need to be associated and fused, and the track-to-track association (TTTA) effect is a key factor that directly affects the performance of the entire system. In order to solve the problem of the low accuracy of TTTA in network radar systems with asynchronous unequal rates, an asynchronous TTTA algorithm based on pseudo nearest neighbor distance is proposed. Firstly, the calculation method of pseudo nearest neighbor distance between the track point and the track data set is defined, then the correlation degree between the two track data sets is obtained by using grey theory, and then the Jonker-Volgenant algorithm is combined with the classical allocation method to judge the TTTA. The algorithm does not need time domain alignment and can effectively avoid the accumulation and propagation of estimation errors. The simulation results show that the algorithm has a high average correct association rate and is less affected by the radar sampling period ratio, startup time, and noise distribution, and the average correct association rate for different movement types of target tracks remains above 99%. Furthermore, compared with other algorithms, this algorithm maintains a stable low level of the number of false associations and the maximum false association rates, and has strong robustness and advantages.
Disruptive Displacement: The Impacts of Industrial Robots on the Energy Industry’s International Division of Labor from a Technological Complexity View
Authors: Zhang Weiming , Peng Jiachao , Zhang Lian
Published: April 2023

In light of the growing economic uncertainties worldwide, the use of industrial robots has emerged as a significant opportunity for improving the production efficiency and the international division of labor in China’s energy industry. This study employed a two-way fixed-effect model utilizing data from 31 Chinese provinces between 2011 and 2019 to investigate the impact of industrial robots on the energy industry’s participation in the international division of labor. The results of the study indicated that the widespread application of industrial robots can boost the international division of labor status of China’s energy sector. This conclusion remains robust even after addressing the potential endogeneity issues and conducting a range of sensitivity tests. Furthermore, our findings suggest that the regions that possess abundant energy resources or exhibit a lower carbon intensity are more likely to leverage the use of industrial robots to increase the technological sophistication and enhance their participation in the international division of labor. The application of industrial robots in the energy industry can enhance the international division of labor through two distinct channels: optimizing the factor structure and reducing the export costs. Our findings have important policy implications for ensuring energy security and improving the energy industry’s participation in the international division of labor.
Spatiotemporal Features and Time-Lagged Effects of Drought on Terrestrial Ecosystem in Southwest China
Authors: Jiang Pan , Wang Yuxi , Yang Yang , Gu Xinchen , Huang Yi , Liu Lei , Liu Liang
Published: April 2023

With global warming, the increase in the frequency and intensity of droughts have severely affected the balance of terrestrial ecosystems. Although the immediate effects of drought on vegetation growth have been widely studied, the time-lagged effects have been neglected, particularly in ecologically fragile karst areas. We examined the vegetation growth trends and abrupt changes in southwest China from 1990 to 2018 by reconstructing the normalized difference vegetation index (NDVI); we then used the standardized precipitation and evapotranspiration index (SPEI) to explore the drought evolution characteristics and the time-lagged effect of drought on vegetation growth. The results showed that 97% of the study area exhibited a greening trend, which accelerated after 1995. Spring drought increased noticeably. We demonstrated that drought had a time-lagged effect on vegetation growth; 27.28% of the vegetation lands had a lag time of less than 3 months, and the mean lagged time in karst areas was shorter than that in non-karst areas. Compared to other vegetation types, the cultivated vegetation had weaker drought resistance, while the mixed-forest had stronger tolerance to drought. This study contributes to a further understanding of the drought–vegetation relationship and has important implications for optimizing vegetation conservation strategies in southwest China while coping with climate change.
A Multipath Data-Scheduling Strategy Based on Path Correlation for Information-Centric Networking
Authors: Xu Yong , Ni Hong , Zhu Xiaoyong
Published: April 2023

Information-Centric Networking (ICN) has revolutionized the manner of content acquisition by shifting the communication mode from host-centric to information-centric. Considering the existing, large amount of IP infrastructure in current networks, the new ICN architecture is proposed to be compatible with existing networks in order to reduce deployment cost. However, due to compatibility with IP networks, ICN data packets must be transmitted through the default path provided by IP routing regulations, which also limits the transmission efficiency and reliability of ICN. In order to address this issue, this paper introduces a multipath transmission method applied in ICN which takes full advantage of the functions and characteristics of ICN and builds multiple end-to-end relay paths by using the ICN routers as relay nodes. We then propose a relay-node-selection algorithm based on path correlation to minimize the impact of overlapping links. Moreover, we comprehensively calculate the path state value by combining the round-trip time and packet loss rate and propose a multipath data-scheduling algorithm based on the path state value. Simulation experiments show that the proposed method can maintain high bandwidth utilization while reducing the number of out-of-order packets.
A Multi-Tissue Gene Expression Atlas of Water Buffalo (Bubalus bubalis) Reveals Transcriptome Conservation between Buffalo and Cattle
Authors: Si Jingfang , Dai Dongmei , Li Kun , Fang Lingzhao , Zhang Yi
Published: April 2023

We generated 73 transcriptomic data of water buffalo, which were integrated with publicly available data in this species, yielding a large dataset of 355 samples representing 20 major tissue categories. We established a multi-tissue gene expression atlas of water buffalo. Furthermore, by comparing them with 4866 cattle transcriptomic data from the cattle genotype–tissue expression atlas (CattleGTEx), we found that the transcriptomes of the two species exhibited conservation in their overall gene expression patterns, tissue-specific gene expression and house-keeping gene expression. We further identified conserved and divergent expression genes between the two species, with the largest number of differentially expressed genes found in the skin, which may be related to structural and functional differences in the skin of the two species. This work provides a source of functional annotation of the buffalo genome and lays the foundations for future genetic and evolutionary studies in water buffalo.
Protective Immunity against Chlamydia psittaci Lung Infection Induced by a DNA Plasmid Vaccine Carrying CPSIT_p7 Gene Inhibits Dissemination in BALB/c Mice
Authors: Wang Chuan , Jin Yingqi , Wang Jiewen , Zheng Kang , Lei Aihua , Lu Chunxue , Wang Shuzhi , Wu Yimou
Published: April 2023

Chlamydia psittaci (C. psittaci), a zoonotic pathogen, poses a potential threat to public health security and the development of animal husbandry. Vaccine-based preventative measures for infectious diseases have a promising landscape. DNA vaccines, with many advantages, have become one of the dominant candidate strategies in preventing and controlling the chlamydial infection. Our previous study showed that CPSIT_p7 protein is an effective candidate for a vaccine against C. psittaci. Thus, this study evaluated the protective immunity of pcDNA3.1(+)/CPSIT_p7 against C. psittaci infection in BALB/c mice. We found that pcDNA3.1(+)/CPSIT_p7 can induce strong humoral and cellular immune responses. The IFN-γ and IL-6 levels in the infected lungs of mice immunized with pcDNA3.1(+)/CPSIT_p7 reduced substantially. In addition, the pcDNA3.1(+)/CPSIT_p7 vaccine diminished pulmonary pathological lesions and reduced the C. psittaci load in the lungs of infected mice. It is worth noting that pcDNA3.1(+)/CPSIT_p7 suppressed C. psittaci dissemination in BALB/c mice. In a word, these results demonstrate that the pcDNA3.1(+)/CPSIT_p7 DNA vaccine has good immunogenicity and immunity protection effectiveness against C. psittaci infection in BALB/c mice, especially pulmonary infection, and provides essential practical experience and insights for the development of a DNA vaccine against chlamydial infection.
Renal Lesions and Nephrotoxicity: Contemporary Challenges and Future Directions
Authors: Plotnikov Egor
Published: April 2023

Renal lesions and nephrotoxicity are major challenges for researchers and patients alike [...]
Insights into the Microbicidal, Antibiofilm, Antioxidant and Toxicity Profile of New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives
Authors: Vlad Ilinca Margareta , Nuță Diana Camelia , Ancuceanu Robert Viorel , Costea Teodora , Coanda Maria , Popa Marcela , Marutescu Luminita Gabriela , Zarafu Irina , Ionita Petre , Pirvu Cristina Elena Dinu , Bleotu Coralia , Chifiriuc Mariana-Carmen , Limban Carmen
Published: April 2023

The unprecedented increase in microbial resistance rates to all current drugs raises an acute need for the design of more effective antimicrobial strategies. Moreover, the importance of oxidative stress due to chronic inflammation in infections with resistant bacteria represents a key factor for the development of new antibacterial agents with potential antioxidant effects. Thus, the purpose of this study was to bioevaluate new O-aryl-carbamoyl-oxymino-fluorene derivatives for their potential use against infectious diseases. With this aim, their antimicrobial effect was evaluated using quantitative assays (minimum inhibitory/bactericidal/biofilms inhibitory concentrations) (MIC/MBC/MBIC), the obtained values being 0.156–10/0.312–10/0.009–1.25 mg/mL), while some of the involved mechanisms (i.e., membrane depolarization) were investigated by flow cytometry. The antioxidant activity was evaluated by studying the scavenger capacity of DPPH and ABTS•+ radicals and the toxicity was tested in vitro on three cell lines and in vivo on the crustacean Artemia franciscana Kellog. The four compounds derived from 9H-fluoren-9-one oxime proved to exhibit promising antimicrobial features and particularly, a significant antibiofilm activity. The presence of chlorine induced an electron-withdrawing effect, favoring the anti-Staphylococcus aureus and that of the methyl group exhibited a +I effect of enhancing the anti-Candida albicans activity. The IC50 values calculated in the two toxicity assays revealed similar values and the potential of these compounds to inhibit the proliferation of tumoral cells. Taken together, all these data demonstrate the potential of the tested compounds to be further used for the development of novel antimicrobial and anticancer agents.
Evaluation of Matrix Metalloproteases by Artificial Intelligence Techniques in Negative Biopsies as New Diagnostic Strategy in Prostate Cancer
Authors: Eiro Noemi , Medina Antonio , Gonzalez Luis O. , Fraile Maria , Palacios Ana , Escaf Safwan , Fernández-Gómez Jesús M. , Vizoso Francisco J.
Published: April 2023

Usually, after an abnormal level of serum prostate-specific antigen (PSA) or digital rectal exam, men undergo a prostate needle biopsy. However, the traditional sextant technique misses 15–46% of cancers. At present, there are problems regarding disease diagnosis/prognosis, especially in patients’ classification, because the information to be handled is complex and challenging to process. Matrix metalloproteases (MMPs) have high expression by prostate cancer (PCa) compared with benign prostate tissues. To assess the possible contribution to the diagnosis of PCa, we evaluated the expression of several MMPs in prostate tissues before and after PCa diagnosis using machine learning, classifiers, and supervised algorithms. A retrospective study was conducted on 29 patients diagnosed with PCa with previous benign needle biopsies, 45 patients with benign prostatic hyperplasia (BHP), and 18 patients with high-grade prostatic intraepithelial neoplasia (HGPIN). An immunohistochemical study was performed on tissue samples from tumor and non-tumor areas using specific antibodies against MMP -2, 9, 11, and 13, and the tissue inhibitor of MMPs -3 (TIMP-3), and the protein expression by different cell types was analyzed to which several automatic learning techniques have been applied. Compared with BHP or HGPIN specimens, epithelial cells (ECs) and fibroblasts from benign prostate biopsies before the diagnosis of PCa showed a significantly higher expression of MMPs and TIMP-3. Machine learning techniques provide a differentiable classification between these patients, with greater than 95% accuracy, considering ECs, being slightly lower when considering fibroblasts. In addition, evolutionary changes were found in paired tissues from benign biopsy to prostatectomy specimens in the same patient. Thus, ECs from the tumor zone from prostatectomy showed higher expressions of MMPs and TIMP-3 compared to ECs of the corresponding zone from the benign biopsy. Similar differences were found for expressions of MMP-9 and TIMP-3, between fibroblasts from these zones. The classifiers have determined that patients with benign prostate biopsies before the diagnosis of PCa showed a high MMPs/TIMP-3 expression by ECs, so in the zone without future cancer development as in the zone with future tumor, compared with biopsy samples from patients with BPH or HGPIN. Expression of MMP -2, 9, 11, and 13, and TIMP-3 phenotypically define ECs associated with future tumor development. Also, the results suggest that MMPs/TIMPs expression in biopsy tissues may reflect evolutionary changes from prostate benign tissues to PCa. Thus, these findings in combination with other parameters might contribute to improving the suspicion of PCa diagnosis.
Microbiome Composition in Microscopic Colitis: A Systematic Review
Authors: Garczyk Aleksandra , Mardas Marcin , Stelmach-Mardas Marta
Published: April 2023

Believed to be a rare cause of chronic diarrhoea, microscopic colitis (MC) is a condition with rising incidence. Many prevalent risk factors and the unknown pathogenesis of MC rationalise the need for studies on microbiota composition. PubMed, Scopus, Web of Science and Embase were searched. Eight case-control studies were included. The risk of bias was assessed with the Newcastle–Ottawa Scale. Clinical details on the study population and MC were poor. The most consistent result among the studies was a decreased Akkermansia genus in faecal samples. Other results were inconsistent due to the different taxonomic levels of the outcomes. Possible changes in different taxa were observed in patients who suffered from MC compared to healthy controls. The alpha diversity compared between MC and the diarrhoea control may suggest potential similarities. The beta diversity in MC compared to healthy and diarrhoeal populations showed no significant outcomes. The microbiome composition in MC possibly differed from the healthy control, but no agreement regarding taxa was made. It might be relevant to focus on possible factors influencing the microbiome composition and its relationship with other diarrhoeal diseases.
Remove, Refine, Reduce: Cell Death in Biological Systems
Authors: Krüger Marcus
Published: April 2023

Cell death is an important biological phenomenon[...]
Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype
Authors: Rojo-Tolosa Susana , Sánchez-Martínez José Antonio , Pineda-Lancheros Laura Elena , Gálvez-Navas José María , González-Gutiérrez María Victoria , Jiménez-Gálvez Gonzalo , Pérez-Ramírez Cristina , Morales-García Concepción , Jiménez-Morales Alberto
Published: April 2023

Omalizumab is a monoclonal antibody indicated for the treatment of severe uncontrolled asthma with an allergic phenotype. Its effectiveness could be influenced by clinical variables and single nucleotide polymorphisms (SNPs) in one or more of the genes involved in the mechanism of action and process of response to omalizumab, and these could be used as predictive biomarkers of response. We conducted an observational retrospective cohort study that included patients with severe uncontrolled allergic asthma treated with omalizumab in a tertiary hospital. Satisfactory response after 12 months of treatment was defined as (1) Reduction ≥ 50% of exacerbations or no exacerbations, (2) Improvement of lung function ≥ 10% FEV1, and (3) Reduction ≥ 50% of OCS courses or no OCS. Polymorphisms in the FCER1A (rs2251746, rs2427837), FCER1B (rs1441586, rs573790, rs1054485, rs569108), C3 (rs2230199), FCGR2A (rs1801274), FCGR2B (rs3219018, rs1050501), FCGR3A (rs10127939, rs396991), IL1RL1 (rs1420101, rs17026974, rs1921622), and GATA2 (rs4857855) genes were analyzed by real-time polymerase chain reaction (PCR) using TaqMan probes. A total of 110 patients under treatment with omalizumab were recruited. After 12 months of treatment, the variables associated with a reduction in exacerbations were the absence of polyposis (odds ratio [OR] = 4.22; 95% confidence interval [CI] = 0.95–19.63), IL1RL1 rs17026974-AG (OR = 19.07; 95% CI = 1.27–547), and IL1RL1 rs17026974-GG (OR = 16.76; 95% CI = 1.22–438.76). Reduction in oral corticosteroids (OCS) was associated with age of starting omalizumab treatment (OR = 0.95; 95% CI = 0.91–0.99) and blood eosinophil levels > 300 cells/µL (OR = 2.93; 95% CI = 1.01–9.29). Improved lung function showed a relationship to the absence of chronic obstructive pulmonary disease (COPD) (OR = 12.16; 95% CI = 2.45–79.49), FCGR2B rs3219018-C (OR = 8.6; 95% CI = 1.12–117.15), GATA2 rs4857855-T (OR = 15.98; 95% CI = 1.52–519.57) and FCGR2A rs1801274-G (OR = 13.75; 95% CI = 2.14–142.68; AG vs. AA and OR = 7.46; 95% CI = 0.94–89.12; GG vs. AA). Meeting one response criterion was related to FCER1A rs2251746-TT (OR = 24; 95% CI = 0.77–804.57), meeting two to age of asthma diagnosis (OR = 0.93; 95% CI = 0.88–0.99), and meeting all three to body mass index (BMI) < 25 (OR = 14.23; 95% CI = 3.31–100.77) and C3 rs2230199-C (OR = 3; 95% CI = 1.01–9.92). The results of this study show the possible influence of the polymorphisms studied on the response to omalizumab and the clinical benefit that could be obtained by defining predictive biomarkers of treatment response.