bluuebunny/crossref_metadata_2025 huggingface dataset:
Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa
Authors: Shahbaz Muhammad Ali , Kuivanen Suvi , Lampinen Riikka , Mussalo Laura , Hron Tomáš , Závodná Táňa , Ojha Ravi , Krejčík Zdeněk , Saveleva Liudmila , Tahir Numan Ahmad , Kalapudas Juho , Koivisto Anne M. , Penttilä Elina , Löppönen Heikki , Singh Prateek , Topinka Jan , Vapalahti Olli , Chew Sweelin , Balistreri Giuseppe , Kanninen Katja M.
Published: December 2023

Background

The neurological effects of the coronavirus disease of 2019 (COVID-19) raise concerns about potential long-term consequences, such as an increased risk of Alzheimer's disease (AD). Neuroinflammation and other AD-associated pathologies are also suggested to increase the risk of serious SARS-CoV-2 infection. Anosmia is a common neurological symptom reported in COVID-19 and in early AD. The olfactory mucosa (OM) is important for the perception of smell and a proposed site of viral entry to the brain. However, little is known about SARS-CoV-2 infection at the OM of individuals with AD.

Methods

To address this gap, we established a 3D in vitro model of the OM from primary cells derived from cognitively healthy and AD individuals. We cultured the cells at the air–liquid interface (ALI) to study SARS-CoV-2 infection under controlled experimental conditions. Primary OM cells in ALI expressed angiotensin-converting enzyme 2 (ACE-2), neuropilin-1 (NRP-1), and several other known SARS-CoV-2 receptor and were highly vulnerable to infection. Infection was determined by secreted viral RNA content and confirmed with SARS-CoV-2 nucleocapsid protein (NP) in the infected cells by immunocytochemistry. Differential responses of healthy and AD individuals-derived OM cells to SARS-CoV-2 were determined by RNA sequencing.

Results

Results indicate that cells derived from cognitively healthy donors and individuals with AD do not differ in susceptibility to infection with the wild-type SARS-CoV-2 virus. However, transcriptomic signatures in cells from individuals with AD are highly distinct. Specifically, the cells from AD patients that were infected with the virus showed increased levels of oxidative stress, desensitized inflammation and immune responses, and alterations to genes associated with olfaction. These results imply that individuals with AD may be at a greater risk of experiencing severe outcomes from the infection, potentially driven by pre-existing neuroinflammation.

Conclusions

The study sheds light on the interplay between AD pathology and SARS-CoV-2 infection. Altered transcriptomic signatures in AD cells may contribute to unique symptoms and a more severe disease course, with a notable involvement of neuroinflammation. Furthermore, the research emphasizes the need for targeted interventions to enhance outcomes for AD patients with viral infection. The study is crucial to better comprehend the relationship between AD, COVID-19, and anosmia. It highlights the importance of ongoing research to develop more effective treatments for those at high risk of severe SARS-CoV-2 infection.

Graphical Abstract
Wilforine inhibits rheumatoid arthritis pathology through the Wnt11/β-catenin signaling pathway axis
Authors: Huang Yurong , Peng Yanhui , Li Hui , Li Chen , Wu Yajie , Wang Xiaomei , Chang Jun , Miao Chenggui
Published: December 2023

Background

Wilforine (WFR) is a monomeric compound of the anti-RA plant Tripterygium wilfordii Hook. f. (TwHF). Whether WFR has anti-RA effect, its molecular mechanism has not been elucidated.

Aim of the study

Our study aims to clarify how WFR inhibits fibroblast-like synovial cells (FLS) activation and improves RA through Wnt11 action on the Wnt11/β-catenin signaling pathway.

Methods

The therapeutic effect of WFR on collagen-induced arthritis (CIA) rats was evaluated using methods such as rat arthritis score. The inhibitory effects and signaling pathways of WFR on the proliferation and inflammatory response of CIA FLS and RA FLS were studied using ELISA, CCK-8, RT-qPCR, Western blot, and immunofluorescence methods.

Results

WFR could effectively alleviate the arthritis symptoms of CIA rats; reduce the levels of IL-6, IL-1β, and TNF-α in the peripheral blood of CIA rats; and inhibit the expression of MMP3 and fibronectin. The data showed that WFR has a significant inhibitory effect on FLS proliferation. Furthermore, WFR inhibited the activation of Wnt/β-catenin signaling pathway and decreased the expression of Wnt11, β-catenin, CCND1, GSK-3β, and c-Myc, while the effects of WFR were reversed after overexpression of Wnt11.

Conclusions

WFR improves RA by inhibiting the Wnt11/β-catenin signaling pathway, and Wnt11 is the direct target of WFR. This study provides a new molecular mechanism for WFR to improve RA and contributes to the clinical promotion of WFR.
Models to predict the radial variation of stiffness, strength, and density in planted noble fir, Norway spruce, western hemlock, and western red cedar in Great Britain
Authors: Gil-Moreno David , MClean J. Paul , Ridley-Ellis Dan
Published: December 2023

Key message

This study compares the measured radial variation in wood stiffness, strength, and density of noble fir, Norway spruce, western hemlock, and western red cedar by developing mixed-effects models for each property using age as the explanatory variable. These models could be used to simulate the effect of rotation length and species choice on sawn wood properties.

Context

Timber production in Great Britain relies primarily on Sitka spruce. The use of multiple species is desirable to mitigate against biotic and abiotic risks posed to a single species. When considering alternative species, quantifying and modeling radial variation in wood properties is important to determine the potential for sawn timber production at a given rotation length.

Aims

To build empirical models for the radial variation in wood properties that can account for species.

Methods

Clear-wood samples were produced along radial transects in trees from four conifer species: Abies procera Rehder, Picea abies (L.) Karst, Tsuga heterophylla (Raf.) Sarg., Thuja plicata Donn. ex D.Don. Modulus of Elasticity, Modulus of Rupture, and density were measured on each species according to established standards. Mixed-effects models were built using ring numbers from the pith and species as explanatory variables.

Results

The same model forms could be used across the four species. Nonlinear models were developed for the Modulus of Elasticity and density. For the Modulus of Rupture, a linear model was most appropriate. The effect of species in the models was significant.

Conclusion

At similar rotation lengths, noble fir, Norway spruce, and western hemlock can produce timber with comparable properties to Sitka spruce. Overall, western red cedar would have worse properties for structural use.
Features and development trends of primary care research conducted by practice-based research networks from 1991 to 2023: a scoping review protocol
Authors: Wang Yang , Cao Xinyang , Xu Zhijie , Fang Hai
Published: December 2023

Background

Practice-based research networks (PBRNs) have been recognized as essential laboratories and mechanisms for developing primary care research. This scoping review aims to examine and map the features and development trends of productivity, research categories, and methods in original primary care research conducted by global PBRNs between 1991 and 2023.

Methods

We have assembled an interdisciplinary team that will undertake this scoping review, following the framework developed by Arksey and O’Malley. Targeted literature includes original primary care research conducted by PBRNs, published from January 1, 1991, to December 31, 2023. An integrated search strategy will gather publications from 3 electronic databases (PubMed, Web of Science, and Embase), 16 major primary health care journals, and 364 relevant organizations. Two experienced researchers will independently screen the titles, keywords, and abstracts of all references and extract data regarding eight key elements. Disagreements between the reviewers will be resolved through group discussions, moderated by a third reviewer. Articles to be included will (1) be conducted in the primary care context, (2) be led by PBRNs, (3) provide a full report of original research, and (4) be published in a peer-reviewed journal between the aforementioned dates in any language. Exclusions encompass reviews, letters, commentaries, case reports, and conference papers. Final data will be displayed using tables and charts according to different conceptual categories.

Discussion

This scoping review is one of the initial attempts to delineate the development trends and features of primary care research conducted by PBRNs. This study will provide reference information for researchers in countries/regions that are building their research infrastructure and capacity in general practice, family medicine, and primary care.

Systematic review registration

Registered in OSF on July 25, 2022 (https://osf.io/zgv9c).
Increased prokaryotic diversity in the Red Sea deep scattering layer
Authors: Huete-Stauffer Tamara Megan , Logares Ramiro , Ansari Mohd Ikram , Røstad Anders , Calleja Maria Lluch , Morán Xosé Anxelu G.
Published: December 2023

Background

The diel vertical migration (DVM) of fish provides an active transport of labile dissolved organic matter (DOM) to the deep ocean, fueling the metabolism of heterotrophic bacteria and archaea. We studied the impact of DVM on the mesopelagic prokaryotic diversity of the Red Sea focusing on the mesopelagic deep scattering layer (DSL) between 450–600 m.

Results

Despite the general consensus of homogeneous conditions in the mesopelagic layer, we observed variability in physico-chemical variables (oxygen, inorganic nutrients, DOC) in the depth profiles. We also identified distinct seasonal indicator prokaryotes inhabiting the DSL, representing between 2% (in spring) to over 10% (in winter) of total 16S rRNA gene sequences. The dominant indicator groups wereAlteromonadalesin winter,Vibrionalesin spring andMicrotrichalesin summer. Using multidimensional scaling analysis, the DSL samples showed divergence from the surrounding mesopelagic layers and were distributed according to depth (47% of variance explained). We identified the sources of diversity that contribute to the DSL by analyzing the detailed profiles of spring, where 3 depths were sampled in the mesopelagic. On average, 7% was related to the epipelagic, 34% was common among the other mesopelagic waters and 38% was attributable to the DSL, with 21% of species being unique to this layer.

Conclusions

We conclude that the mesopelagic physico-chemical properties shape a rather uniform prokaryotic community, but that the 200 m deep DSL contributes uniquely and in a high proportion to the diversity of the Red Sea mesopelagic.
The impact of referring patients with drug-resistant focal epilepsy to an epilepsy center for presurgical diagnosis
Authors: Mann Leonhard , Rosenow Felix , Strzelczyk Adam , Hattingen Elke , Willems Laurent M. , Harter Patrick N. , Weber Katharina , Mann Catrin
Published: December 2023

Background

Epilepsy surgery is an established treatment for drug-resistant focal epilepsy (DRFE) that results in seizure freedom in about 60% of patients. Correctly identifying an epileptogenic lesion in magnetic resonance imaging (MRI) is challenging but highly relevant since it improves the likelihood of being referred for presurgical diagnosis. The epileptogenic lesion’s etiology directly relates to the surgical intervention’s indication and outcome. Therefore, it is vital to correctly identify epileptogenic lesions and their etiology presurgically.

Methods

We compared the final histopathological diagnoses of all patients with DRFE undergoing epilepsy surgery at our center between 2015 and 2021 with their MRI diagnoses before and after presurgical diagnosis at our epilepsy center, including MRI evaluations by expert epilepsy neuroradiologists. Additionally, we analyzed the outcome of different subgroups.

Results

This study included 132 patients. The discordance between histopathology and MRI diagnoses significantly decreased from 61.3% for non-expert MRI evaluations (NEMRIs) to 22.1% for epilepsy center MRI evaluations (ECMRIs; p < 0.0001). The MRI-sensitivity improved significantly from 68.6% for NEMRIs to 97.7% for ECMRIs (p < 0.0001). Identifying focal cortical dysplasia (FCD) and amygdala dysplasia was the most challenging for both subgroups. 65.5% of patients with negative NEMRI were seizure-free 12 months postoperatively, no patient with negative ECMRI achieved seizure-freedom. The mean duration of epilepsy until surgical intervention was 13.6 years in patients with an initial negative NEMRI and 9.5 years in patients with a recognized lesion in NEMRI.

Conclusions

This study provides evidence that for patients with DRFE—especially those with initial negative findings in a non-expert MRI—an early consultation at an epilepsy center, including an ECMRI, is important for identifying candidates for epilepsy surgery. NEMRI-negative findings preoperatively do not preclude seizure freedom postoperatively. Therefore, patients with DRFE that remain MRI-negative after initial NEMRI should be referred to an epilepsy center for presurgical evaluation. Nonreferral based on NEMRI negativity may harm such patients and delay surgical intervention. However, ECMRI-negative patients have a reduced chance of becoming seizure-free after epilepsy surgery. Further improvements in MRI technique and evaluation are needed and should be directed towards improving sensitivity for FCDs and amygdala dysplasias.
Status epilepticus in patients with genetic generalized epilepsy: a case series study
Authors: Hu Gengyao , Wang Bi , Chen Beibei , Wang Zezhi , Chen Ze , Liu Yonghong
Published: December 2023

Background

Genetic generalized epilepsy (GGE) accounts for nearly one-third of all epilepsies. The feature of status epilepticus (SE) in patients with GGE has been rarely studied. We aimed to determine the electroclinical characteristics of SE in patients with GGE.

Methods

In this retrospective study, nine patients with GGE were enrolled at Xijing Hospital, Xi’an, China from May 2014 to May 2020. SE was confirmed by 24-h video-EEG recording. The demography, clinical manifestation, brain MRI and SE pattern were analyzed.

Results

Of the nine patients in the study, seven were female. The mean age of the patients at the time of inclusion was 16.8 years (range 7–31 years), and the mean age at the onset of epilepsy was 10.9 years (range 6–17 years). The follow-up time ranged from 3 months to 6 years. Myoclonic absence status was identified in four patients showing eyelid myoclonia with absence and one patient showing perioral myoclonia with absences. Myoclonic SE was identified in three patients showing juvenile myoclonic epilepsy. Autonomic SE was found in one patient with eyelid myoclonia with absence. SE was terminated by oral midazolam in four patients. In the other five patients, SE terminated spontaneously.

Conclusions

The seizure type of SE in patients with GGE is often consistent with their major symptoms. Oral midazolam may be an option to terminate SE in patients with GGE.
Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature
Authors: Wakabayashi Munehiro , Kikuchi Yoshinori , Yamaguchi Kazuhisa , Matsuda Takahisa
Published: December 2023

Trousseau syndrome is a paraneoplastic syndrome associated with a risk of poor prognosis. We reviewed the survival time and prognosis of patients with Trousseau syndrome. We identified 40 cases from 28 reports of Trousseau syndrome due to pancreatic cancer. We analyzed 20 cases based on reports providing sufficient information on the stage/location of pancreatic cancer and survival time after Trousseau syndrome. The median survival time was 2.0 months. There was no statistical difference between performance status (PS) 0–1 and PS 4, stages I–III and IV, and pancreatic head and body/tail. However, statistically significant differences were noted between the median survival time of patients who continued treatment for pancreatic cancer even after Trousseau syndrome and those who discontinued treatment (P = 0.005). Although only a small number of cases were analyzed in this study, the results indicated that patients with pancreatic cancer who developed Trousseau syndrome had a poor prognosis, and chemotherapy should be continued, if possible.
Joint wave-equation inversion of Rayleigh and Love dispersion curves
Authors: Li Jing , Zhang Chang , Hanafy Sherif , Yu Han , Bai Lige
Published: December 2023

Wave-equation dispersion (WD) inversion techniques for surface waves have proven to be a robust way to invert the S-wave velocity model. Unlike 1D dispersion curve inversion, WD method obviates the need for a layered model assumption and reduces the susceptibility to cycle-skipping issues in surface wave full-waveform inversion. Previous WD inversion experiments conducted on Rayleigh and Love waves have highlighted that inverting Love waves yields better stability due to their independence from the P-wave velocity model. Nevertheless, Rayleigh waves possess the advantage of greater penetration depth compared with Love waves with similar wavelengths. Therefore, combining the two types of surface waves is a feasible way to improve the accuracy of S velocity tomograms. In light of this, we develop a novel approach: a joint WD inversion encompassing Rayleigh and Love waves. This innovative technique adjusts the weighting of individual WD gradients using the sensitivity factor of an equivalent layered model, offering a significant advancement in subsurface characterization. Synthetic model tests demonstrate that the joint WD inversion method can generate a more accurate S-wave velocity model, particularly in the presence of complex low-velocity layers or high-velocity layers, when compared with individual wave WD inversion techniques. Simultaneously, the results of field tests validate the effectiveness of the proposed joint WD inversion strategy in producing a more dependable S-wave velocity distribution that aligns closely with the actual geologic structure.
Sensory Co-laboring
Authors: Pardo Pedraza Diana
Published: December 2023

Demining has not been an exclusively human affair. Mine detection dogs have been indispensable in the work of detection and in the slow but essential effort to regain trust in mine-suspected landscapes. Famously renowned for their extraordinary sensory perception, physical strength, and mental traits, they are part of human-nonhuman units training and working together to perceive explosives’ odors. This article considers the role of these units, known in Colombia as binomios caninos, in the strenuous task of mine clearance. Drawing on eighteen months of ethnographic engagement with global and local humanitarian demining efforts in Colombia, it examines detection choreographies and daily interactions, proposing to think of their joint work in terms of sensory co-laboring. Bringing anthropological work on collaboration between worlds, sensory labor, and animal work into dialogue, this composite term foregrounds detection as labor and as a result of human-nonhuman cooperation. It also highlights the asymmetrical field in which these collaborators converge and the divergent desires, affects, and attachments that mobilize their participation in demining. Mine detection is conceptualized as a sensory task through which dogs and humans intra-act, both together and apart. Recognizing this partial connection allows us to rethink how humans and other creatures are ontologically reconstituted and how overlapping histories of warfare and humanitarianism, legacies of animal behavioral practice, and instrumental-affective interactions shape these reconstitutions.
A community-driven approach to enhancing the quality and interpretability of microscopy images
Authors: Jambor Helena Klara
Published: December 2023

Scientific publications in the life sciences regularly include image data to display and communicate revelations about cellular structure and function. In 2016, a set of guiding principles known as the ‘FAIR Data Principles’ were put forward to ensure that research data are findable, accessible, interoperable and reproducible. However, challenges still persist regarding the quality, accessibility and interpretability of image data, and how to effectively communicate microscopy data in figures. This Perspective article details a community-driven initiative that aims to promote the accurate and understandable depiction of light microscopy data in publications. The initiative underscores the crucial role of global and diverse scientific communities in advancing the standards in the field of biological images. Additionally, the perspective delves into the historical context of scientific images, in the hope that this look into our past can help ongoing community efforts move forward.
The gonadal health status of Cyprinidae fish species collected from the river impacted by anthropogenic activities
Authors: Dane Hatice , Şişman Turgay
Published: December 2023

Many freshwater ecosystems are contaminated with heavy metals released by municipal wastewater, cultivation and factory wastewater. The aim of the study was to evaluate the negative impact of metal pollution on the fish reproductive system. It was performed using the gonadal histopathology, hepatosomatic index (HSI), and gonadosomatic index (GSI) of three fish species, Capoeta damascina, Squalius semae and Alburnus sellal inhabiting in Karasu River (Erzurum, Turkey) contaminated by various anthropogenic activities. The highest GSI values were determined for each sex according to the seasons, and lower GSI values were observed in polluted stations in all three species. It was observed that HSI values in fish varied significantly from station to station. In addition, an increase in ovarian and testicular lesions (degeneration in oocyte and spermatocytes, atresia, congestion, infiltration, edema, vascular hypertrophy, fibrosis) was detected in the polluted areas. The results clearly showed that the metal pollution in the river adversely affected the reproductive system of the fish species living in the river.
Types of Creative Work in Literary Reading Lessons
Authors: Nikitina E.
Published: December 2023

The article discusses the problem of developing creativity in literary reading lessons in elementary school, emphasizing the importance of creative works of various types for better understanding by primary schoolchildren of the idea of a work of art and the development of interest in textual activity. The characteristics of different types of creative work based on works of art are given, and the methodology for their organization at the first stage of school education is outlined.
Features of the Formation of Historical Ideas in Younger Schoolchildren During Lessons about the Surrounding World
Authors: Vinogradova Natalya
Published: December 2023

The article, based on the requirements of the Federal State Educational Standard and the Federal Work Program for Primary General Education for the purposes of studying the history of Russia and the content of historical ideas, discusses the problem of developing historical ideas among junior schoolchildren as a component of the integrated course “The World Around us.” Approaches to designing the process of studying the most striking pages of Russian history are analyzed, taking into account the psychological characteristics of the assimilation of historical time and space by children of primary school age. Examples of tasks aimed at understanding the basic characteristics of historical phenomena are given: fact, image, connection and detail.
Ethno-medicinal plants used by Jadh Bhotiya Community of District Uttarakashi, Uttarakhand, India
Authors: Devi Usha , Bagri Ajendra , Bajpai Atal Bihari
Published: December 2023

In the present study, our aim was to document the traditional knowledge regarding ethno-medicinal plants used by the Jadh-Bhotiya community in the Uttarakashi district (Uttarakhand, India). A total of 54 taxa, belonging to 49 genera and 31 families, were recorded with medicinal properties. Lamiaceae, Liliaceae and Orchidaceae were the dominant families (in terms of number of species), while the top genera included Berberis, Habenaria, Malaxis and Polygonatum. Herbs constituted the dominant life form (82%), followed by shrubs and trees (9% each). Roots (20%) and the whole plant (13%) showed a higher proportion of use for medication. Powder (33%) and paste (20%) were the most frequently used drug preparation methods. Regional conservation assessment analysis revealed that 76% of the species were recorded under the 'Least Concern' (LC) category, followed by 'Vulnerable' (VU) with 13% of the species, and 11% of the species were recorded under the 'Near Threatened' (NT) category. Aconitum heterophyllum, Arnebia benthamii, Nardostachys jatamansi, Rheum australe, Saussurea obvallata and Taxus wallichiana were recorded under the ‘Near Threatened’ (NT) category. Angelica glauca, Carduus edelbergii, Dactylorhiza hatagirea, Ephedra gerardiana, Lilium polyphyllum, Malaxis acuminata, and Malaxis muscifera were recorded under the ‘Vulnerable’ (VU) category, while the remaining species were recorded under the ‘Least Concern’ (LC) category. The knowledge about therapeutic information concerning plants in the study area and elsewhere is diminishing day by day. Regional-level conservation status of plant species can be helpful in the global conservation status assessment. It is recommended that conservation measures be applied for the betterment of those species falling under various conservation categories, especially the threatened ones. Additionally, more ethno-medicinal studies are recommended in such remote regions to further enhance our understanding of traditional medicinal practices and contribute to the conservation of indigenous plant knowledge.
Risk of Land Degradation: A Case Study of Phu Yen Province, Vietnam
Authors: Nga Nguyen Thi Thu , Phuong Pham Mai , Khanh Nguyen Quoc , Hanh Tong Thi , Quoc Pham Bao , Lahori Altaf Hussain , Yeremenko Sergiy , Tyshchenko Vasyl , Murasov Rustam
Published: December 2023

The issue of the land degradation vulnerability index (LDVI) is multifaceted, encompassing climate, soil, vegetation, policy formulation, and human actions. In Vietnam, the convergence of climatic fluctuations and human impact results in phenomena, such as soil sealing, erosion, salinization, and landscape fragmentation. These phenomena are recognized as significant triggers of land degradation. This paper seeks to present a method for assessing a land's susceptibility to degradation by utilizing ten ecological 10 criteria: NDVI; slope; bulk density (cg/cm3); cation exchange capacity in the soil (CEC; mmol(c)/kg); Soil organic carbon stock (SOC; dg/kg), pH; Nitrogen (N; cg/kg); soil thickness (cm); soil surface temperature LST (0C); precipitation of the driest quarter (mm). The research results show that Song Hinh and Son Hoa communes are standing on the most land degradation vulnerability. Some criteria that are considered important in assessing land degradation by the analytic hierarchy process (AHP) technique are NDVI, followed by slope, nitrogen, bulk density, and soil thickness. The results of the study are consistent with records in localities that are often under pressure from drought. Extreme LDVI areas were larger identified on low mountains, slope terrain, and precipitation of driest quarter under 200mm, expanding on the agricultural areas with 40km2 total province agriculture area, followed by grassland (20.3 km2), natural forests (17.2 km2), plantation forests (8.2 km2), residences (8.2 km2), and bare land (8.15 km2). Poor land management practices, such as improper construction, inadequate water management, and lack of terracing, can contribute to soil erosion and land degradation. This LDVI assessment process can be applied to some tropical countries. The NDVI index combined with the slope, nitrogen, bulk density, and soil thickness can be exploratory indicators of land sensitivity to land degradation.
Badania nad historią pietyzmu na przełomie XVII i XVIII wieku. Uwagi w związku z monografią Liliany Lewandowskiej
Authors: Kizik Edmund , Ptaszyński Maciej
Published: December 2023

Artykuł jest polemiką z analizą sporów wokół pietyzmu w Gdańsku przedstawioną przez Lilianę Lewandowską. Autorzy, odnosząc się do najnowszego stanu badań nad pietyzmem, postulują szersze wykorzystanie dostępnych źródeł archiwalnych oraz rekonstrukcję historycznego kontekstu: uwzględnienie sytuacji międzynarodowej, polityki Rady Miejskiej, układu sił politycznych w Gdańsku, a także reakcji społecznych na polemiki.
Transformaciones en el espacio urbano-rural en Colombia y su impacto en el suministro de agua
Authors: Bernal Pedraza Andrea Yolima , Licona Calpe Winston
Published: December 2023

Los Objetivos de Desarrollo Sostenible, con su premisa de “no dejar a nadie atrás”, apuntan al seguimiento de las desigualdades sociales con énfasis en la brecha urbano-rural. Desde 2016, en Colombia existen los “esquemas diferenciales” como conjunto de normas, políticas, instrumentos estadísticos y programas para promover el suministro de agua y saneamiento en zonas urbanas de difícil acceso y gestión, y en zonas rurales. Sin embargo, esta dicotomía no responde a la complejidad de los territorios, sus conflictos socioambientales y transformaciones aceleradas del difuso límite urbano-rural. Los autores anotan imaginarios y conceptos que cuestionan la dicotomía urbano-rural desde la literatura, y presentan una caracterización de las transformaciones del territorio que inciden en la gestión comunitaria del agua, a partir de sus observaciones y de la escucha de testimonios en territorio. Los escasos estudios sobre territorios urbano-rurales y oferta de bienes públicos limitan el estudio.
Stabilizing Grand Cooperation via Cost Adjustment: An Inverse Optimization Approach
Authors: Liu Lindong , Qi Xiangtong , Xu Zhou
Published: December 2023

For an unbalanced cooperative game, its grand coalition can be stabilized by some instruments, such as subsidization and penalization, that impose new cost terms to certain coalitions. In this paper, we study an alternative instrument, referred to as cost adjustment, that does not need to impose any new coalition-specific cost terms. Specifically, our approach is to adjust existing cost coefficients of the game under which (i) the game becomes balanced so that the grand coalition becomes stable, (ii) a desired way of cooperation is optimal for the grand coalition to adopt, and (iii) the total cost to be shared by the grand coalition is within a prescribed range. Focusing on a broad class of cooperative games, known as integer minimization games, we formulate the problem on how to optimize the cost adjustment as a constrained inverse optimization problem. We prove [Formula: see text]-hardness and derive easy-to-check feasibility conditions for the problem. Based on two linear programming reformulations, we develop two solution algorithms. One is a cutting-plane algorithm, which runs in polynomial time when the corresponding separation problem is polynomial time solvable. The other needs to explicitly derive all the inequalities of a linear program, which runs in polynomial time when the linear program contains only a polynomial number of inequalities. We apply our models and solution algorithms to two typical unbalanced games, including a weighted matching game and an uncapacitated facility location game, showing that their optimal cost adjustments can be obtained in polynomial time.

History: Accepted by Area Editor Andrea Lodi for Design & Analysis of Algorithms—Discrete.

Funding: This work was supported by the National Natural Science Foundation of China [Grants 72022018 and 72091210]; the Research Grants Council of the Hong Kong SAR, China [Grant 16210020]; Hong Kong Polytechnic University [Grant P0032007]; and the Youth Innovation Promotion Association, Chinese Academy of Sciences [Grant 2021454].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.0268 .
Robust Queue Inference from Waiting Times
Authors: Bandi Chaithanya , Han Eojin , Proskynitopoulos Alexej
Published: December 2023

Modeling and decision making for queueing systems have been one of fundamental topics in operations research. For these problems, uncertainty models are established by estimation of key parameters such as expected interarrival and service times. In practice, however, their distributions are unknown, and decision makers are only given historical records of waiting times, which contain relevant but indirect information on the uncertainties. Their complex temporal dependence on the queueing dynamics and the absence of distributional information on the model primitives render estimation of queueing systems remarkably challenging. In the paper “Robust Queue Inference from Waiting Times” by Chaithanya Bandi, Eojin Han, and Alexej Proskynitopoulos, a new inference framework based on robust optimization is proposed to estimate unknown service times from waiting time observations. This new framework allows data-driven, distribution-free estimation on unknown model primitives by solving tractable optimization problems.
"E Eu Não Sou Uma Mulher?" Confluências Entre a Psicanálise e a Mulher Negra
Authors: Corsino Debora , Cordeiro Silvia
Published: December 2023

Este trabalho é um recorte de nossa pesquisa de mestrado, que se propôs a investigar, a partir de narrativas de mulheres negras, as percepções e significados de suas experiências enquanto mulheres, como também identificar os marcadores da diferença de suas vivências em torno da feminilidade e o que faz uma mulher negra experimentar a feminilidade de uma forma própria. Apoiamo-nos na perspectiva metodológica da pesquisa psicanalítica dos fenômenos sociais e políticos, por compreender que nossa questão advém de um impasse político-social, que foi examinado a partir da relação transferencial e da indissociabilidade entre teoria, clínica e pesquisa. Utilizamos o recurso de entrevistas enquanto instrumento para a produção do material de análise. Assim, entrevistamos três mulheres negras, convidadas a compartilhar suas histórias e experiências enquanto mulheres. A partir do debate teórico e do material levantado nas entrevistas, foi possível identificar as complexidades do processo de tornar-se mulher e negra, a partir dos marcadores difundidos no laço social, por possuir especificidades subjetivas. Para além disso, pensar no significado dos símbolos utilizados por mulheres negras e contar com uma outra mulher negra para apresentar esses elementos são direções que podem impactar a experiência da feminilidade dessas mulheres.
O Real da Violência: Relato de Experiência com um Coletivo de Mulheres
Authors: Buechler Flávia , Perrone Cláudia , Silva Gabriela , Rancich Juliana
Published: December 2023

Este trabalho tem como objetivo, a partir da experiência e do testemunho de um Coletivo de Mulheres, propor uma leitura do que nomeamos como o Real da violência por meio do ensino de Lacan e comentadores. Diferente do Real enquanto fundamento ausente ou falta-a-ser, o Real da violência se insere historicamente no dia a dia e na vida de determinados corpos brasileiros, precisamente os corpos negros, femininos e periféricos. Em vista do cenário de impasses socio-políticos do Brasil, mas também de potentes vozes e ações que têm surgido das comunidades atravessadas por estruturas de violência, a experiência do Coletivo ilustra o presente trabalho, a fim de demonstrar caminhos possíveis para um saber-fazer com esse Real ao qual seus filhos e a comunidade estão mais expostos. À luz de conceitos da Teoria Feminista, como, por exemplo, a noção de interseccionalidade e a categoria corpo-território, endossamos essa discussão que demanda à Psicanálise conversar com outros campos do saber. Empreitada que exige engajamento ético e político dos psicanalistas, em especial dos que exercem a práxis analítica no Brasil.
História e Diplomacia: notícias bibliográficas escritas por Rollie Edward Poppino na Hispanic American Historical Review (1951-1973)
Authors: Pacheco Larissa Penelu Bitencourt
Published: December 2023

O presente texto tem como objetivo analisar as publicações assinadas por Rollie Edward Poppino (1922-2010), na revista HAHR – Hispanic American Historical Review. O historiador, que pesquisou o Brasil e realizou estudos sobre o interior do país, os sertões e as tradições sociais e que ao longo da década de 1950 e 1960, fez pesquisas sobre a América Latina nos serviços de investigação do Departamento de Estado. Ao mesmo tempo, continuou participando de circuitos de divulgação acadêmica da História do Brasil, em periódicos especializados. Procuramos avaliar como essas publicações se integravam com os temas da diplomacia estadunidense para o continente, versando, entre outros temas, sobre o marxismo e o comunismo, o desenvolvimento, a modernização e a interpretação sobre as ditaduras. Os documentos foram consultados no próprio periódico, através de portais de pesquisa em que se acessou os textos que compõem sua trajetória como historiador do Brasil. A História Intelectual e a abordagem das suas redes de contato foram intercaladas com o apontamento sobre sua biografia,  publicações, relações, leituras que realizou e intercâmbios que foram feitos durante sua carreira.
Representação social da saúde para os umbandistas e o cuidado transcultural de Madeleine Leininger
Authors: Silva Gabriel Santos da , Gomes Antonio Marcos Tosoli , Brandão Juliana de Lima , Mello Lívia Fajin de , Souza Karen Paula Damasceno dos Santos
Published: December 2023

Objetivo: analisar a estrutura da representação social da saúde para umbandistas com vistas à abordagem do cuidado transcultural. Método: estudo qualitativo descritivo-exploratório, fundamentado na abordagem estrutural da Teoria das Representações Sociais e Teoria Transcultural de Madeleine Leininger. Os participantes foram captados pela técnica Snowball, que responderam a um questionário online, contendo caracterização sociodemográfica; escala DUREL; e instrumento de evocações livres. Os dados foram analisados por estatística descritiva e as evocações pela análise prototípica e de similitude. Resultados: participaram 110 invíduos, predominando mulheres (70%), entre 29 e 39 anos, e com alta religiosidade. A análise prototípica evidenciou vida, bem-estar e ter-fé como provavelmente centrais e hospital e médico como elementos de contraste. A análise de similitude demonstrou além dos elementos previamente e provavelmente centrais, cuidado e corpo com comportamento de centralidade. Considerações finais: concepções multidimensionais de bem-estar e qualidade de vida marcam esta representação, embasada pela alta religiosidade e o cuidado transcultural e integral em saúde.
Repercussões e fatores preponderantes da atuação de enfermeiras especialistas: visão de gestores
Authors: Melo Bianca Calheiros Cardoso de , Costa Jéssika Wanessa Soares , Mourão Vanessa Gomes , Silva Fillipi André dos Santos , Oliveira Jonas Sâmi Albuquerque de , Medeiros Soraya Maria de
Published: December 2023

Objetivo: analisar a visão dos gestores sobre as repercussões e fatores preponderantes da atuação de enfermeiras especialistas em hospitais universitários federais. Método: estudo descritivo-exploratório, com abordagem qualitativa, realizado com gestores de hospitais universitários do Nordeste brasileiro, no período de outubro a novembro de 2021, após aprovação em Comitê de Ética e Pesquisa. As análises ocorreram através do software Atlas.ti® e do referencial teórico de Bardin. Resultados: neste estudo, em entrevistas realizadas com cinco gestores, duas categorias foram identificadas e analisadas, sendo a primeira sobre as repercussões e a segunda sobre os fatores preponderantes no mercado de trabalho da atuação de enfermeiras especialistas. Conclusão: os gestores relacionam positivamente a contratação de enfermeiras especialistas, uma vez que, agregam qualidade à assistência, embora existam fatores dificultadores, como a inflexibilidade de remanejamento, adoecimento e perfil feminino da classe de enfermagem.
Clinical analysis of 114 cases of bronchiolitis in infants
Authors: Shi Cheng , Wu Meng-Hua , Zuo An , Yang Mi-Mi , Jiang Rong-Rong
Published: December 2023

BACKGROUND

Bronchiolitis is a common lower respiratory tract infection in infants and young children. Severe cases may be accompanied by obvious dyspnea and oxygen saturation decline.

AIM

To summarize the clinical features, standard diagnosis, and treatment of bronchiolitis.

METHODS

This is a retrospective analysis of 114 pediatric patients (74 males, 40 females) who were first diagnosed as having bronchioles at the Department of Pediatrics of Tongling Maternal and Child Health Hospital from January 2019 to December 2019. The clinical features, imaging features, treatment, and other clinical data were recorded and analyzed.

RESULTS

The age of onset of the disease was mainly from 1 mo to 6 mo (75.4%), and the time to hospital visit was mostly from the 2nd day to the 4th day of the course of the disease (75.4%). Lung imaging examination showed increase in lung texture, fuzzy (93.8%). The main treatment was atomization therapy: Budesonide combined with terbutaline (45.6%) and budesonide combined with salbutamol (38.5%). The average hospitalization time was 7.1 ± 2.4 d, and the overall cure rate was 94.7%. In patients without bacterial infection, the use of antibiotics significantly prolonged the length of hospital stay (7.8 ± 2.5 d vs 5.7 ± 1.8 d) and improved the cure rate (98.3% vs 87.9%, P < 0.05).

CONCLUSION

Infants with bronchiolitis are mainly male and tend to have a good prognosis. However, the unneeded use of antibiotics may prolong the length of hospital stay significantly, which imposes the burden both on the patients and hospital system.
Efficacy of surgical resection and ultra-reduced tension suture combined with superficial radiation in keloid treatment
Authors: Hu Xiao-Ying , Yang Qiao , Guan Xiao-Yu , Li Jin-Ying , Wang Ling-Ling , Li Kun , Zhang Xiao-Tao
Published: December 2023

BACKGROUND

There are many available treatment options for keloid; however, single treatments are usually less effective. Therefore, more scientifically rational and effective combined treatment methods should be sought to solve the pain associated with keloids.

AIM

To explore the efficacy and safety of surgical resection and ultra-reduced tension suture combined with superficial radiation as keloid treatment.

METHODS

Fifteen keloid patients admitted to Qingdao Eighth People's Hospital from June 2020 to January 2022 were enrolled in this retrospective analysis. All patients underwent a comprehensive treatment approach comprising surgical resection, ultra-reduced tension suture incision, and superficial radiation therapy within 24 h postoperatively. The modified Vancouver Scar Scale (mVSS) and Patient and Observer Scar Assessment Scale (POSAS) were used to evaluate the treatment effect, whereas the efficacy, adverse effects, and recurrence rate were observed according to the 12-mo follow-up after treatment.

RESULTS

The mVSS and POSAS scores at 1 and 6 mo after combination treatment decreased compared to before treatment (P < 0.001), and the overall response rate was 93.3%. Only one case recurred, yielding a 6.7% recurrence rate. The incidence of local chromour sedimentation rate in 1–3 mo after radiotherapy was 33.3% (5 patients), all subsiding after 6–9 mo, without complications, such as delayed wound healing or dermatitis.

CONCLUSION

Surgical resection, super subtraction sutures, and superficial radiotherapy are treatment methods with short courses, low recurrence rates, and good safety profiles.
Never waste a crisis: initiatives responding to men who use violence during COVID-19
Authors: Humphreys Cathy , Richardson-Foster Helen , Robinson Michele , Sijnja Jennifer , McKibbin Gemma , Stanley Nicky
Published: December 2023

A crisis creates a time when normal problem-solving mechanisms are thrown into disarray. The COVID-19 pandemic plunged individuals and service systems into crisis. While recognising the destructive impact on health and well-being for those involved, the aim of this study was to explore opportunities for change created during a crisis, addressing the question: What has been learnt under COVID-19 about delivering domestic abuse services to perpetrators in the UK and Australia? Documentary analysis (31 documents reviewed in Australia, and 180 searched and analysed in the UK) and interviews (24 interviews with practitioners and policy and practice leads in the UK, and 11 interviews, and one focus group in Australia) were used to explore innovations in responses to perpetrators. Two key shifts in the delivery of services to men who use violence were identified: the pivot to remote delivery; and the emergence of interventions to provide accommodation and support for perpetrators. The study demonstrated that the policy window could open at a time of crisis to support innovative developments. Early evaluations highlighted positive developments. However, further research is needed to understand more fully the implications for safety and accountability.
Researching gender-based violence remotely during a pandemic: challenges, opportunities and methodological implications
Authors: Taylor-Dunn Holly , Bates Lis , Reed Dominic , Hopkins Anna , Morrison Shona
Published: December 2023

There has been increased awareness of the unique challenges faced by those researching gender-based violence (GBV) in recent years. While much of the literature has rightly focused on the needs of participants (as victim/survivors), less has been written around the needs of researchers. Yet we know that researching GBV can have both positive and negative impacts on researchers (Nikischer, 2019) and it has recently been recommended that researchers have access to clinical supervision when regularly exposed to traumatic material (Williamson et al, 2020). This article draws on reflections from research carried out during the COVID-19 pandemic regarding the reasons why victims of domestic abuse and/or sexual violence may withdraw from the criminal justice process. The research team were provided with independent clinical supervision by a qualified therapist with expertise in interpersonal abuse throughout the duration of the project. Analysis of the researchers’ reflections suggest that while the move to remote research during the pandemic created opportunities in terms of flexibility there were additional emotional challenges to those experienced pre-pandemic. Importantly, this exploratory article shares reflections on the value of clinical supervision for addressing these challenges and recommends that all GBV researchers have access to this vital resource.