bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Effect of Main Components of Wild Thyme on Covid-19 by Computational Methods
Authors: Kaya Serpil , Erkan Sultan , Karakaş Duran
Published: December 2023

Aromatic plant species of the genus thymus have an important role as they have therapeutic properties such as antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. It is also known that such plants strengthen the immune system and help cope with infectious diseases such as colds and flu. In this study, the effects of thymol, p-cymene, -terpinene, bornyl acetate, borneol, carvacrol, thymol methyl ether, thymol acetate, which are the main components of wild thyme (thymus serpyllum L.), on Covid-19 were investigated at the molecular level. Optimizations and molecular docking were done in Docking Server with the MMFF94 method. Major components of wild thyme were docked separately against 6LU7 protein representing the first gene form of Covid-19 and 7KDL protein representing the mutated form. Docking poses and binding energies between target proteins and wild thyme components were calculated. The results were compared with favipiravir, an antiviral drug developed against influenza virus and also used in the treatment of Covid-19. It was found that the thymol molecule, one of the main components of wild thyme, has the highest biological activity against both 6LU7 and 7KDL protein chains of Covid-19.
Investigation of the Effect of Indatraline on Oxidative Damage Induced by Hydrogen Peroxide in C6 Glioma Cell Line
Authors: Yulak Fatih , Üngür Bünyamin
Published: December 2023

Oxidative stress is defined as an imbalance between the generation of reactive oxygen species (ROS) and their scavenging. Indatralin, which has serotonin reuptake inhibitory activity, has not yet been studied for its ability to prevent oxidative damage. Our research's objective was to find out how indatraline defends against oxidative damage. C6 cells were used in the study and four different cell groups were created. The control group received no therapy at all. For 24 hours, cells in the H2O2 group were exposed to 0.5 mM H2O2. The indatraline group received indatraline treatments for 24 hours at various doses (0.5, 1, 2.5, 5 and 10 μM). For one hour, indatraline was administered to the indatraline + H2O2 group at various concentrations (0.5, 1, 2.5, 5 and 10 μM) before the group was subjected to 0.5 mM H2O2 for 24 hours. Following the occurrence of oxidative damage, total antioxidant status (TAS) and total oxidant status (TOS) levels were determined. Cell viability was also evaluated using the XTT assay. As a result, after hydrogen peroxide-induced oxidative damage, indatraline at doses of 10, 5, and 2.5 μM showed a protective effect by significantly enhanced cell survival in C6 cells(p < 0.001). Additionally, indatraline boosted the lowered TAS level while decreasing the elevated TOS levels following hydrogen peroxide-induced oxidative damage (p<0.001).
A Study on The Optical Properties of Long-Infrared Intraband Transitions of Quadruple Gaas/Alxga1-Xas Quantum Well Under Applied Electric Field
Authors: Altun Didem
Published: December 2023

Semiconductor-emitting/absorbing infrared devices are in the common interest of the scientific and industrial community due to their broad application in these fields. GaAs/AlGaAs based devices are one of the most studied semiconductor heterostructures. In this study, I have aimed to design GaAs/AlGaAs quantum well (QW) semiconductor heterostructures to emit/absorb in the long infrared region and studied the optical properties. To do that, I have designed a quadruple QW, which is composed of GaAs/Al0.44Ga0.56As QW and quantum barriers (QB). I have solved the time-independent Schrödinger equation using the finite element method-based matlab code under effective mass approximation. The wave functions and corresponding energy eigenvalues are obtained for varied electric field (EF) intensities. I have shown that our design can operate up to 80 kV/cm, which is the limit for first bounded energy eigenstates. It is observed that E_32 transition provides long-infrared emission/absorption corresponding to the 0.12-0.14 eV transition energy and it is constant with increased EF intensity. In addition, it is seen that the overlap of the wave functions is increasing with EF intensity which enhances radiative transition in the structure. I have calculated the linear absorption coefficient and refractive index change. I have observed that the absorption coefficient of E_32 transition is increasing with EF intensity while E_31 is decreasing and E_21 is constant. As a last, I have shown that EF intensity has a minor effect on refractive index change.
Evaluation of the Interactions of Cabozantinib with Topoisomerase Enzymes by in vitro Enzyme Activity Assays, and its Effects on Cancer Cell Proliferation
Authors: Oflaz Feyza , Ünal Naz , Gungor Burcin , Cantürk Pakize
Published: December 2023

The discovery of many drugs in recent years provides a definitive solution in the treatment of various diseases, but today, despite the discovery of many effective anticancer drugs, there are various types of cancer that have limitations in treatment and are still not completely curable. Since most of these limitations are due to cancer cells gaining resistance or compounds only being effective in certain types of cancer cells, the search for more effective anticancer drugs that are also effective in these types of cancer is inevitable. Cabozantinib is in medical use as a highly effective anticancer drug in various types of cancer, such as medullary thyroid cancer and kidney cancer. The anticancer properties of the Cabozantinib compound have attracted more attention in recent years, however, more studies are needed to define the anticancer activities of this compound. In our study, the interactions of Cabozantinib with topoisomerase enzymes, were demonstrated through in vitro enzyme activity tests, and the anti-proliferative effect of Cabozantinib was studied on MCF7, A549 and PC3 cell lines. By analyzing the interactions of the Cabozantinib with topoisomerases, the action mechanisms of the compound at the molecular level was evaluated.
Plasma kallistatin levels in patients with COVID-19
Authors: YUCEL Kamile , YILDIZ Salih , GURBUZ Ali Fuat
Published: December 2023

Purpose: The aim of this study was to evaluate kallistatin levels in patients diagnosed with COVID-19 and compare them with healthy controls.

Materials and Methods: A total of 40 patients diagnosed with COVID-19, and 45 healthy controls were included in the study. The patient group was divided into 2 groups: patients treated in the service (n:20) and patients treated in the intensive care unit (n:20). Kallistatin levels were measured using the ELISA method.

Results: There was a significant difference in kallistatin levels between the patient group (n:40) and the control group (n:45). There was no significant difference in kallistatin between COVID-19 patients treated in the service and those treated in the intensive care unit. We found that the AUC for kallistatin was 0.856 in the ROC analysis performed between the patient and control groups. When comparing service and ICU patients in terms of laboratory parameters, there was a significant difference between the groups due to elevated potassium, AST, creatinine, ferritin, HGB and LDH in ICU patients.

Conclusion: As a result, kallistatin levels were significantly higher in the patient group than in the control group. Comprehensive studies with more patients are needed to understand whether kallistatin is elevated in COVID-19 patients due to the effects of COVID-19 or to eliminate oxidative stress.
Melanosis coli
Authors: KURT İdris , UZUNOĞLU Ebru Erol
Published: December 2023

Melanosis Coli is a rare and unusual appearance of the colon with dark brown pigmentation in a snakeskin-like pattern. Owing to its rarity and different view, it cannot be distinguished from ischemic colitis, especially in acute settings. Unfortunately, some patients are diagnosed after colectomy. The malignant potential of the disease remains controversial. In this article, we discuss a patient who was found to have melanosis coli and then briefly examine the relevant medical literature.
XVII Congreso Internacional Gallego-Portugués de Psicopedagogía
Authors: Peralbo Manuel
Published: December 2023

- Promover los intercambios científicos entre investigadores y profesionales en las áreas de Docencia, Educación y Psicología; - Presentar y debatir los resultados de los proyectos de investigación y los programas de intervención educativa, en especial los que se derivan más recientemente de esta crisis post-pandémica (post-covid-19) que nos ha afectado y preocupado tanto; - Profundizar la multidisciplinariedad en temas psicológicos y educativos y en relación con las Ciencias Psicológicas y Ciencias de la Educación; - Contribuir a la mejora del sistema educativo formal e informal, a la formación de sus diferentes agentes y a la cualidad de sus organizaciones y contextos en atención a los objetivos de desarrollo sustentable.
Aplicación de la ley de protección de datos en los centros educativos de la Región de Murcia (España)
Authors: Díaz Santa-María Yonatan , López-Ríos Luís , Molina-Saorín Jesús
Published: December 2023

Este trabajo pretende realizar un análisis de la aplicación de la normativa de protección de datos en centros educativos. Más concretamente, se dirige a elaborar una propuesta de instrumentos de recogida de datos de carácter personal para centros docentes. Este objetivo se abordará mediante estudio legal y un posterior análisis de los documentos utilizados para este fin en cinco colegios de la Comunidad Autónoma de la Región de Murcia. La aplicación de estas normas merece una especial atención cuando nos referimos a centros educativos, debido a que la mayoría de datos de carácter personal que se tratan pertenecen a menores de edad. Por este motivo, pueden surgir dudas como, por ejemplo, ¿cuáles son los límites para el tratamiento de los datos? ¿Quién puede prestar el consentimiento para tratar datos personales de menores de edad? ¿Qué datos ser pueden exigir en los centros educativos? ¿Qué requisitos deben cumplir los documentos de recogida de datos? A lo largo del estudio se abordarán estas y otras cuestiones hasta obtener la información necesaria para realizar la propuesta de instrumentos de recogida de datos para centros educativos.
Análisis de las necesidades básicas y experiencias turísticas satisfechas en los recursos y atractivos turísticos del Paraguay. Estudio de caso San Carlos del Apa, Concepción, en el periodo 2022
Authors: Trinidad Angélica María , Sutty-Segovia Hernán Isidro
Published: December 2023

Este trabajo tiene como propósito determinar si los recursos y atractivos de la localidad de San Carlos del Apa en Paraguay, cuentan con potencial para satisfacer necesidades básicas del visitante y mediante qué experiencias. Para lo cual se recurrió a una investigación con un enfoque cuantitativo, transversal y descriptivo. Fueron analizados 21 recursos mediante la técnica de la observación cuyo instrumento fue una ficha de 4 dimensiones y 28 ítems: Servicios Básicos (8), Servicios Complementarios (6), Necesidades Básicas (5) y Experiencias Ofrecidas (9), en julio de 2022. Los principales resultados demuestran que 19% de los recursos están en condiciones óptimas para el turismo en función de sus servicios básicos y complementarios, así mismo, mediante estos recursos se pueden satisfacer cinco necesidades básicas: disfrutar, relajarse, descubrir, reunirse y la tradición religiosa, siendo las de mayor cumplimiento en los recursos (90%) descubrir y disfrutar. En cuanto a las experiencias ofrecidas son variadas, pero destacan los relacionados con las Áreas Naturales (57%) y Prácticas Deportivas (52%). Concluyendo finalmente que la localidad cuenta con algunos recursos y atractivos potenciales de satisfacer las necesidades de los visitantes, sin embargo, la mayoría de los recursos aún requieren de intervención y planificación para su mejor aprovechamiento.
Пограничные опухоли яичников
Authors: Давыдова И. Ю. , Валиев Р. К. , Карселадзе А. И. , Ашрафян Л. А. , Новикова Е. Г. , Урманчеева А. Ф.
Published: December 2023

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Общие принципы проведения противоопухолевой лекарственной терапии
Authors: Трякин А. А. , Бесова Н. С. , Волков Н. М. , Гладков О. А. , Карасева В. В. , Сакаева Д. Д. , Фадеева Н. В. , Федянин М. Ю.
Published: December 2023

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Гастроинтестинальные стромальные опухоли
Authors: Никулин М. П. , Архири П. П. , Мещеряков А. А. , Носов Д. А. , Стилиди И. С. , Филоненко Д. А.
Published: December 2023

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Нейроэндокринные неоплазии желудочнокишечного тракта и поджелудочной железы
Authors: Артамонова Е. В. , Горбунова В. А. , Делекторская В. В. , Емельянова Г. С. , Жуликов Я. А. , Любимова Н. В. , Маркович А. А.
Published: December 2023

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Герминогенные опухоли
Authors: Румянцев А. А. , Волкова М. И. , Гладков О. А. , Матвеев В. Б. , Проценко С. А. , Трякин А. А. , Тюляндин С. А. , Федянин М. Ю.
Published: December 2023

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Хронический болевой синдром у взрослых онкологических больных
Authors: Когония Л. М. , Новиков Г. А. , Орлова Р. В. , Сидоров А. В. , Королева И. А. , Сакаева Д. Д.
Published: December 2023

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Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats
Authors: Tjahyadi David , Parwanto Edy , Sisca Sisca , Xavierees Endrico , Jaya Edy Hosea , Digambiro Reza Aditya , Oladimeji Ashaolu Victoria , Tjahyadi Joey Joshua Vidova , Gabrielle Laurentia
Published: December 2023

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats.
MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data.
ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction.
ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts
Authors: Hidayati Nur Ilham Risma , Kusuma Indra , Poerwanto Eko
Published: December 2023

BACKGROUNDHuman dermal fibroblast (HDF) cultures can be used as a regenerative agent for wound healing. Fetal bovine serum (FBS) as a culture supplement is derived from animals, therefore not being constant in composition, causes variations in research results, thus requiring a substitute such as KnockOut serum replacement (KOSR). This study evaluated the defined KOSR as FBS substitute for HDF culture by measuring the relative expression of basic fibroblast growth factor (bFGF) and keratinocyte growth factor (KGF) messenger RNA (mRNA), HDF cell proliferation, and HDF migration.
METHODSHuman dermal fibroblast culture was divided into 2 intervention groups receiving KOSR 5% and KOSR 10%, respectively, and a control group receiving FBS 10%. Reverse transcription polymerase chain reaction (RT-PCR) was used for bFGF and KGF mRNA relative expression at the fifth passage (P5). Cell counting kit-8 (CCK-8) reagent was used for the HDF cell proliferation assay at P5 and the scratch assay was used for HDF cell migration at P6. Data were analyzed using dependent t-test, One-way ANOVA, or Kruskal-Wallis test.
RESULTSThere were no significant differences in bFGF and KGF mRNA relative expression and HDF migration velocity between the intervention and control groups (p>0.05 and p>0.05, respectively). The doubling time of the KOSR 5% group showed no significant difference (p>0.05), but KOSR 10% and FBS 10% showed significant differences between treatment days 2-6 and treatment days 6-10 (p<0.05).
CONCLUSIONSThe KOSR 10% was comparable to FBS 10% in supporting bFGF and KGF mRNA relative expression, HDF cell proliferation, and HDF cell migration in HDF culture.
Childhood blindness from surge of advanced stage retinopathy of prematurity in premature infants during the COVID-19 pandemic: a case series
Authors: Yulia Dian Estu , Soeharto Diajeng Ayesha
Published: December 2023

Background Retinopathy of prematurity (ROP) is a proliferative disease of the ocular retinal vasculature in premature infants, being a leading cause of preventable childhood blindness. The COVID-19 pandemic serves as an additional barrier to access to care and referral, potentially leading to more cases of advanced stage ROP. Although surgery can be done, ROP at this stage is highly associated with poor functional outcome irrespective of surgery. This case series aims to report advanced stage (stage 5) ROP in premature infants during the COVID-19 pandemic.
MethodsA retrospective case series of medical records of paediatric patients with ROP was performed at Cipto Mangunkusumo National Referral Hospital between March 1, 2020 and December 31, 2021. This case series included new patients that presented to our clinic from March 2020 to December 2021 with stage 5 ROP.
ResultsA total of 19 eyes of 10 patients with stage 5 ROP were included in this study. Mean chronologic age at presentation to our referral centre was 7.0 4.0 months. Upon presentation, all had stage 5 ROP with negative blink reflex to light, and none of the eyes in this cohort underwent surgical intervention. Mean gestational age was 30.3 3.2 weeks and mean birth weight was 1,276.7 366.4 g.
ConclusionThere was an observable surge of stage 5 ROP at our referral centre with irreversible blindness. This highlights the need for proper ROP screening in all hospitals in Indonesia to prevent delay in detection and care of advanced stage ROP.
Release of retromalleolar flexor retinaculum and combined flexor digitorum longus and flexor hallucis longus Z-plasty in checkrein deformity: a case report
Authors: Irianto Komang Agung , Leonarto Enrico , Handoyo Henry Ricardo
Published: December 2023

BackgroundCheckrein deformity is a rare abnormality comprising flexor hallucis longus (FHL) tendon entrapment in the posterior foot due to post-traumatic or ischemic retraction of the FHLtendon following soft tissue trauma. The diagnosis is essentially clinical, but complemented by imaging to rule out unrecognized causes and evaluate the fracture healing process. This case report is the first Indonesian study to describe release of the flexor retinaculum and Z-plasty (lengthening) of flexor digitorum longus (FDL) and FHL tendons through a medial retromalleolar approach to repair the deformity.
Case DescriptionWe present the case of a 51-year-old male who complained of clawing of his right first and second toes. The interest of this study lies in the fact that this patient had never experienced ankle or distal tibial fractures, only a trivial injury two years back when the patient kicked a stone at work and had a bruise on his right second toe with no fracture. Exploration of FHL tendons was performed at the level of the midfoot. The patient was planned for surgery with a medial retromalleolar ankle approach, which facilitates the release of the flexor retinaculum, in conjunction with a Z-tenotomy on the FHL and FDL tendons.
ConclusionA correction was achieved, and two months post-surgery there were no recurrences of the deformity. However, this surgical procedure requires more cases to support an evaluation of its effectiveness. We suggest that exploration at the ankle and midfoot should be the primary surgical intervention in similar cases of checkrein deformity.
The Relationship Between Work Alienation Behavior And Cyberloafing: A Study on Healthcare Professionals
Authors: SEMİZ Emre , SÖYÜK Selma
Published: December 2023

This study was conducted to determine the relationship between work alienation and cyberloafing among healthcare professionals. Besides, it is aimed to reveal the differences between both concepts according to sociodemographic variables. In the current research, a questionnaire form consisting of a cyberloafing scale, a work alienation scale, and sociodemographic characteristics were used as data collection tools. The questionnaire consists of 51 questions and 5 dimensions. The population of the research consists of 4042 people working at a public hospital, a hospital of health science university, and a private hospital. A total of 602 questionnaires were evaluated in these institutions. Based on the findings, there was a relationship between work alienation and cyberloafing behaviors of health professionals and some sociodemographic variables. In addition, there was a low-level positive and significant relationship between work alienation and cyberloafing levels of healthcare professionals. As a result of the correlation analysis in the study, a low-level positive and significant relationship was found between work alienation and cyberloafing. In addition, significant differences were found between work alienation, cyberloafing, and sociodemographic variables.
Problems and prospects for finding new pharmacological agents among adenosine receptor agonists, antagonists, or their allosteric modulators for the treatment of cardiovascular diseases
Authors: Perfilova V.N. , Muzyko E.A. , Taran A.S. , Shevchenko A.A. , Naumenko L.V.
Published: December 2023

A1-adenosine receptors (A1AR) are widely distributed in the human body and mediate many different effects. They are abundantly present in the cardiovascular system, where they control angiogenesis, vascular tone, heart rate, and conduction. This makes the cardiovascular system A1AR an attractive target for the treatment of cardiovascular diseases (CVD). The review summarizes the literature data on the structure and functioning of A1AR, and analyzes their involvement in the formation of myocardial hypertrophy, ischemia-reperfusion damage, various types of heart rhythm disorders, chronic heart failure, and arterial hypertension. Special attention is paid to the role of some allosteric regulators of A1AR as potential agents for the CVD treatment.
The search for potential hypotensive peptides in the amino acid sequence of human renalase and their identification in proteolytic fragments of this protein
Authors: Fedchenko V.I. , Veselovsky A.V. , .Kopylov A.T , Medvedev A.E.
Published: December 2023

Renalase (RNLS) is a secretory protein discovered in 2005. It plays an important role in the regulation of blood pressure. Studies by two independent laboratories have shown that administration of purified recombinant RNLS reduced blood pressure in experimental animals. However, the mechanisms of the antihypertensive effect of RNLS still remain unclear, especially in the context of the shift in the catalytic paradigm of this protein. In addition, there is growing evidence that endogenous plasma/serum RNLS, detected by enzyme immunoassay, is not an intact protein secreted into the extracellular space, and exogenous recombinant RNLS is effectively cleaved during short-term incubation with human plasma samples. This suggests that the antihypertensive effect of RNLS may be due to peptides formed during proteolytic processing. Based on the results of a bioinformatics analysis of potential RNLS cleavage sites (Fedchenko et al., Medical Hypotheses, 2022; DOI: 10.1016/j.mehy.2022.110895), a number of short peptides have been identified in the RNLS sequence that show similarity to fragments of known peptide inhibitors of angiotensin-converting enzyme. Some of them were found as a part of larger RNLS peptides, formed during RNLS cleavage by chymotrypsin and, and to a lesser extent, by trypsin.
ВЕРХНЕУДИНСКИЙ/УЛАН-УДЭНСКИЙ ПЕРИОД В ЖИЗНИ МОНГОЛЬСКОГО УЧЕНОГО БАЗАРЫН ШИРЕНДЫБА (1932–1937 гг.)
Authors:   Бурятский государственный университет имени Доржи Банзарова, А. М. Шойдонова
Published: December 2023

В статье осуществлена попытка изучить особенный период в жизни выдающегося монгольского ученого, историка, академика, создателя Монгольского университета и Монгольской академии наук — Базарын Ширендыба. С 1932 по 1937 г. он обучался на Монгольском рабочем факультете г. Верхнеудинска (с 1934 г. — г. Улан-Удэ) Бурят-Монгольской АССР. Данная проблематика затрагивается в специальных исследованиях эпизодически и недостаточно глубоко. Большее внимание, что вполне справедливо, уделяется иркутскому периоду жизни Б. Ширендыба. На основании источников архивного фонда «Монгольский рабочий факультет» представлены сведения, раскрывающие условия проживания и обучения монгольских студентов в этом учебном заведении.
ОБЩЕСТВЕННАЯ ДЕЯТЕЛЬНОСТЬ САВРАННЫ ЯКОВЛЕВНЫ ЕРБАНОВОЙ в 1960–1970 гг.
Authors:   Бурятский государственный университет имени Доржи Банзарова, А. Э. Будаева
Published: December 2023

Данная статья посвящена общественной деятельности Савранны Яковлевны Ербановой в 1960–1970 гг. Автор отмечает, что к этому времени она добилась реабилитации своего супруга Михея Николаевича Ербанова (советский государственный и партийный деятель, ответственный/первый секретарь Бурят-Монгольского областного комитета Всероссийской коммунистической партии большевиков Бурят-Монгольской республики (1928–1937)) и в 1956 г. вернулась из Казахстана в Бурятию, где была восстановлена на прежнем месте работы (Госплан Бурят-Монгольской Автономной Советской Социалистической республики) в должности экономиста отдела. Основной своей целью Савранна Яковлев-на считала полную реабилитацию своего мужа и соратника. В статье рассмотрена ее деятельность в 1960–1970 гг. и освещены вопросы сохранения исторической памяти о ней. Отмечено, что в рассматриваемый период за вклад в развитие общества получила заслуженное признание.
ВЕРОИСПОВЕДНАЯ ПОЛИТИКА ГОСУДАРСТВА ПО ОТНОШЕНИЮ К «НОВЫМ СЕКТАМ» В ЗАБАЙКАЛЬЕ В НАЧАЛЕ ХХ в.
Authors:   Бурятский государственный университет имени Доржи Банзарова, С. З. Ахмадулина
Published: December 2023

Статья посвящена анализу функционирования «новых сект» на территории Забайкалья в начале XX в. Автором в вводной части рассмотрены вопросы реформирования вероисповедной политики в указанный период. Революционные события в России в начале XX в., демократизация российского общества повлияли на трансформацию религиозного законодательства по отношению к сектам. Основная часть посвящена некоторым аспектам истории возникновения и развития «новых сект» на территории Забайкалья, дана целостная характеристика особенности функционирования их деятельности. В заключение автор приходит к выводу, что свобода вероисповеданий, декларированная в Указе императора Николая II, не только легализовала и активизировала деятельность многих сектантских общин, но и повлияла на создание новых.
ПОВСЕДНЕВНОСТЬ ФРОНТОВОГО СТУДЕНЧЕСТВА ПОСЛЕВОЕННОГО ЛЕНИНГРАДА В ВОСПОМИНАНИЯХ У.-Ж. Ш. ДОНДУКОВА
Authors:   Государственный архив Республики Бурятия, Я. Р. Казанцев
Published: December 2023

В статье на основе воспоминаний профессора У.-Ж. Ш. Дондукова показана студенческая повседневность послевоенного времени. Изображены бытовые и повседневные трудности, с которыми сталкивались студенты тех лет, культурная жизнь послевоенного Ленинграда глазами У.-Ж. Ш. Дондукова, а также кратко рассмотрена его биография. Кроме того, в статье отражены сложности адаптации ветеранов Великой Отечественной войны в мирной повседневной жизни на фоне полученных ими травм — как физических, так и психологических. Автор приходит к выводу, что повседневная жизнь студенчества имела двойственный характер. Болезни, нехватка средств, обстановка послевоенного периода — все это было в жизни студентов, но, несмотря на это, происходили и положительные моменты, сопровождавшие молодых людей во время студенчества.
Formalizing the organizational structure of an on the basis of the GERT-network model
Authors: Ковалев И.В. , Иконникова М.Ф. , Подоплелова В.А.
Published: December 2023

Представлен подход к формализации организационной структуры предприятия на основе сетевой GERT-модели, что позволит обеспечить планирование времени лица, принимающего решение, при заданных критериях и массивах данных, необходимых для принятия решения. В качестве объекта исследования рассматривается процесс принятия решения о согласовании первичной потребности под закупку на предприятии. Представленная в нотации EPC-модель процесса «согласовать потребность под закупку» преобразована в GERT-сеть. Дано описание процедуры преобразования. Выявлена возможность преобразования GERT-сети под исполнителей функций с целью дальнейшей реструктуризации организационной структуры бизнес-процесса. Представлены результаты расчета полученной GERT-сети с учетом особенностей рассмотренного бизнес-процесса. Предложенные эквивалентные преобразования GERT-сети обеспечивают возможность автоматизации моделирования и, следовательно, позволяют выполнить эффективную реорганизацию организационной структуры предприятия.

The article presents an approach to formalizing the organizational structure of an enterprise based on the GERT-network model, which will ensure the planning of the time of the decision maker, given the criteria and data arrays necessary for making a decision. As an object of study, the process of making a decision on the coordination of primary needs for purchase at an enterprise is considered. The “reconcile purchase requirement” process model presented in the EPC notation has been transformed into a GERT network. The description of the conversion procedure is given. The possibility of transforming the GERT-network for function performers with the aim of further restructuring the organizational structure of the business process is revealed. The results of the calculation of the obtained GERT-network are presented, taking into account the features of the considered business process. The proposed equivalent transformations of the GERT network provide the possibility of modeling automation and, therefore, allow you to perform an effective reorganization of the organizational structure of the enterprise.
To the problem of determining the value of information generated in the course of innovation project implementation
Authors: Клименко И.С. , Палкин Е.А. , Белова Н.А.
Published: December 2023

Проведен анализ связи ценности (полезности) информации с ее стоимостью. В порядке развития семантики критерия Харкевича предложена пятиуровневая лингвистическая ранговая шкала для измерения ценности информации. Показано, что повышение точности модели ситуации принятия решения, на основе которой принимается управленческое решение, обусловлено процедурой измерения количественных данных, а достижение полноты синтезируемого информационного продукта связано с расширением области ее применения за счет структуризации метаданных. Обоснована семантика группы критериев оценивания качества управленческих решений и эффективности процесса управления проектом.

The relationship between the value (utility) of information and its cost is analyzed. In order to develop the semantics of the Harkiewicz criterion, a five-level linguistic ranking scale for measuring the value of information is proposed. It is shown that the increase in the accuracy of the model of the decision-making situation, on the basis of which a managerial decision is made, is conditioned by the procedure of measuring quantitative data, and the achievement of the completeness of the synthesized information product is associated with the expansion of its application due to the structurization of metadata. The semantics of the group of criteria for assessing the quality of management decisions and the effectiveness of the project management process is substantiated.
Automated information and analytical system for the approval of electronic documents on the example of work programs of disciplines
Authors: Нагаев Р.А. , Полевщиков И.С.
Published: December 2023

Представлены результаты разработки моделей и прототипа автоматизированной информационно-аналитической системы согласования документации образовательного процесса на примере рабочих программ дисциплин. Модели и программные модули автоматизированной информационно-аналитической системы позволяют автоматизировать процесс согласования рабочих программ дисциплин с учетом их версионности и версионности алгоритма согласования, выполнять мониторинг процесса согласования, а также совместимы с информационной системой вуза. Применение автоматизированной информационно-аналитической системы позволяет оперативно получать сотрудникам вуза (преподавателям, заведующим кафедрами и др.) актуальную информацию о работе над рабочими программами для дальнейшего принятия решений, что способствует повышению эффективности создания документации учебного процесса.

The results of the development of models and a prototype of the automated information and analytical system for the coordination of the documentation of the educational process are presented on the example of the work programs of disciplines. Automated information and analytical system models and software modules allow automating the RAP approval process, taking into account the versioning of the work programs of disciplines and the versioning of the approval algorithm, monitoring the approval process, and are also compatible with the information system of the university. The use of Automated information and analytical system allows the university staff (teachers, heads of departments, etc.) to receive up-to-date information on the work on the work programs of disciplines for further decision-making. This helps to increase the efficiency of creating documentation of the educational process.
Psychiatric evaluation and support for the elderly undergoing elective surgery
Authors: Qaffas Mohammed F. , Alenezi Bandar S. , Zoghby Ahmed K. , Saad Ahmed A. , Alkhelaiwi Hanan S. , Maashi Afnan M. , Alshehri Abdulaziz A. , Halawani Abdullah A. , Alrowaili Khaled A. , Alameer Hassan T. , Alfaraj Fadhel F.
Published: December 2023

Providing evaluation and support for individuals who choose to undergo surgery is an essential aspect of comprehensive healthcare. With the global population aging, it's becoming more common for elderly individuals to opt for surgeries. This requires understanding how health impacts surgical outcomes in this vulnerable group. This study delves into the presentation and management of factors throughout the entire surgical process, including before, during, and after surgery. The clinical presentation covers existing health conditions, cognitive issues, emotional responses, and ethical considerations related to decision-making abilities. Recognizing these factors is crucial in order to provide tailored interventions that promote the well-being of patients and improve overall outcomes. Clinical management involves measures before surgery, collaborative care models during the period and strategies to prevent or address psychiatric complications after surgery. Ethical considerations are consistently important throughout this process, especially concerning decision-making abilities. This comprehensive approach involves psychiatrists, geriatricians, anesthetists and other healthcare professionals who work together to enhance the well-being of surgical patients. As our population continues to age, further research and attention on aspects of care within this demographic are vital for providing comprehensive and patient-centered healthcare.
Mass spectrometry in clinical laboratory: applications and future prospects
Authors: Ghonaim Alanoud G. , Bakr Faten A. , Alturki Suzan N. , Aljohani Amani A. , Almansour Hawazen S. , Albalawy Mabrooka A. , Alqarni Khalid S. , Alsaadi Nadiah R. , Gharawi Ali Y. , Alharthy Raied S. , Alaskar Ahmad S.
Published: December 2023

Innovations in laboratory medicine face additional challenges due to the unmet need for extremely precise methods of disease diagnosis. Developments in mass spectrometry-based disease biomarker identification are constantly expanding the field of clinical diagnosis. More mass spectrometry-based in vitro diagnostics are anticipated to move from the bench to the bedside shortly, although several are currently incorporated into standard clinical procedures. The molecular detection by mass spectrometry technique is very effective in diagnosis of the disease and therapeutic monitoring because of its extremely high sensitivity, specificity, and short turnaround time. Mass spectrometry is a potent analytical instrument that may be used to analyse a variety of materials and matrices; its use in clinical laboratory medicine applications is rising. For clinical prognostics and diagnostic purposes, mass spectrometry imaging has been widely utilized to distinguish between healthy and diseased tissues. Modern single-cell studies will benefit from its cutting-edge applications, which will offer comprehensive cellular biochemical data for mechanistic comprehension and, eventually, the development of therapeutic interventions. Within the field of laboratory medicine, the application of mass spectrometry is crucial, especially in terms of diagnostics and therapeutic drug monitoring. This review on the clinical application of mass spectrometry and its future prospects promises an insightful exploration of the evolving landscape of mass spectrometry in clinical settings, delving into its current applications and shedding light on its potential future advancements, for which a comprehensive search in the PubMed, ScienceDirect, and Web of Science databases was conducted.
Evaluation of maxillary sinus dimensions and volume in different sagittal and vertical facial types: A CBCT based study
Authors: Jain Dhruv , Nimbalkar Kunal  A , Datana Sanjeev , Chopra Sukhbir  S
Published: December 2023

The study was carried out to evaluate the dimensions and volume of maxillary sinus along with its distribution among different sagittal and vertical skeletal facial types.

A sample of 90 patients was segregated into three sagittal groups based on ANB angle which was further subdivided into three vertical subgroups based on SN-GoGn angle using NNT software. The volumetric assessment was carried out usingHoros software while the linear measurements were performed on CBCT images analysed in NNT software. The inter-group statistical comparison of means of continuous variables was done using Analysis of Variance (ANOVA) with Bonferroni’s multiple group comparisons.

The maxillary sinus volume did not differ significantly across different sagittal and vertical skeletal patterns, the mean sinus volume being 13.08 (+/- 5.38) cu mm among the study population. The maxillary sinus length in Class I skeletal pattern was 3.65 cm (Hyperdivergent group), 3.64 cm (normodivergent group) and 3.52 cm (Hypodivergent group).

The distribution of maxillary sinus dimensions did not differ significantly across the different skeletal and vertical facial types. The only statistically significant finding was the greater maxillary sinus length in all three types of vertical skeletal patterns of Class I as compared to Class III malocclusion.
UTILIZAÇÃO DE RESÍDUOS SÓLIDOS PARA CONFECÇÃO DE JOGOS EDUCATIVOS
Authors: Ribeiro Iracira José da Costa , Silva Tamires Pereira da , Formiga Maria Martins , Nunes Sara Hellen de Almeida , Nascimento Pedro Henrique Alexandre do , Madruga Rebeca Parente Miranda , Campos Romilda Aucicleia Souza , Negocio Tatiana Petrucci
Published: December 2023

O desenvolvimento e crescimento das cidades têm criado problemas pela produção excessiva de resíduos sólidos, sendo necessário o gerenciamento correto entre coleta, transporte e destinação do lixo. Quando descartados inadequadamente, os resíduos contaminam o meio ambiente, o que pode inviabilizar o uso do solo ou causar doenças, além de impactar os recursos não renováveis, a flora e a fauna, causando marginalização de determinada área. Tudo isso compromete o meio ambiente e o convívio social. O projeto relatado neste texto teve como objetivo disseminar para a comunidade as possibilidades de reuso e reciclagem de resíduos sólidos, na forma de confecção de jogos educativos, de modo a colaborar com a educação ambiental e conservação do meio ambiente. Para tanto, foi realizado um levantamento dos locais de descarte de resíduos, a coleta dos resíduos que podem ser reaproveitados e o desenvolvimento de jogos educativos. Foram realizadas oficinas para a confecção de jogos, usando diversos resíduos com materiais diferentes. As ações foram realizadas no Campus do IFPB na cidade de Monteiro e na Casa de Acolhimento São Sebastião, no mesmo município. Foram criados oito tipos de jogos, usando resíduos de madeira, garrafas PET, tampas, palitos de churrasco, pregos, papelão, papel, cápsulas de café, CD’s, pinos de torneiras, entre outros. O texto analisa as diferentes interações com os jogos conforme o tipo e a faixa etária escolar. Conclui-se que este trabalho atingiu os resultados esperados, promovendo a educação ambiental por intermédio da criação de jogos educativos, pois despertou a conscientização sobre a geração de resíduos e o seu descarte, incentivando o reuso e reciclagem de muitos materiais que antes eram descartados.
Christian and Muslim Faith in the Same God after the Second Vatican Council
Authors: Krupa Jozef
Published: December 2023

This article engages in a discussion about whether Christians and Muslims believe in the same God. It first presents the opinions of the authors who take a negative view, then the opinions of those who take a positive view. It also gives one Muslim viewpoint on the subject. In the next part, based on the letter of Pope Gregory VII, the Second Vatican Council, the address of Paul VI, the address of John Paul II, the Document on Human Fraternity for World Peace and Living Together, the address by Pope Francis at an interreligious meeting in Ur, and concluded by the Prayer of the Children of Abraham, it claims that Christians and Muslims believe in the same God. The author does not address the issue of every religion believing in the same God differently. In objecting to the view of the common belief of both monotheistic religions in the same God with the fact that Muslims do not recognize the Most Holy Trinity, the author points out that even Jews do not believe in it and no one disputes that Jews and Christians believe in the same God.
Białko CD14 jako modulator odpowiedzi zapalnej
Authors: Ciesielska Anna , Ben Amor Ichrak , Kwiatkowska Katarzyna
Published: December 2023

CD14 is one of the key proteins involved in the activation of the inflammatory response of immune cells. CD14 binds bacterial lipopolysaccharide (LPS) and transfers its molecules to the complex of Toll-like receptor 4 (TLR4) and MD-2 protein, which in turn triggers pro-inflammatory signaling pathways necessary to combat infection. CD14 determines the final shape of the pro-inflammatory reaction of cells to LPS, serving as a transporter of this endotoxin and also as a regulator of TLR4 activity. In addition, CD14 transports other molecules of microbial or endogenous origin to their target receptors/proteins, participating in the activation of pro-inflammatory signaling pathways triggered by the presence of pathogens, as well as tissue damage. Currently, more attention is paid to the role of the CD14 protein in the development of non-infectious diseases such as autoimmune diseases, metabolic diseases and cardiovascular diseases.
Biologiczne wspomaganie leczenia ortopedycznego
Authors: Pawlak Maciej , Wałecka Joanna , Bąkowski Paweł , Tyczewska Agata , Grzywacz Kamilla
Published: December 2023

Damage to the musculoskeletal system significantly impairs mobility and quality of life, limiting everyday activities. For a successful orthopedic treatment, anatomical, physiological and biomechanical factors must be taken into account as they all influence tissue healing. It is therefore of crucial importance to support traditional treatment with biological therapies, as they facilitate the regeneration of the tissue microarchitecture. Such orthobiologics work at the cellular level (orthobiologics rich in mesenchymal cells or growth factors) or at the tissue level (matrices for repairing e.g. cartilage). In this review, we describe the most frequently used orthobiologics rich in mesenchymal cells (bone marrow, autologous adipose tissue, tenocytes, umbilical cord, urine and bursa) and growth factors, presenting the molecular basis of their functioning and their clinical effectiveness.
O caso da redução de velocidade nas marginais da cidade de São Paulo como experiência de lutas por ressignificação do espaço urbano
Authors: Bastos Antonio Fagner da Silva , Mello Sérgio Carvalho Benício de , Silva Daniella Ramos da
Published: December 2023

Sob o principal argumento de proporcionar um trânsito mais seguro, a Prefeitura de São Paulo implementou o Plano de Proteção à Vida (PPV), uma série de medidas para acalmar o trânsito no espaço viário da cidade. Entre elas, uma que gerou consideráveis controvérsias foi a redução dos limites de velocidade nas marginais Pinheiros e Tietê implementada em julho de 2015. Este artigo visa compreender como se deram as lutas pela da redução dos limites de velocidade das marginais tornando possível sua implementação. Para isso, buscaremos identificar quem foram os sujeitos envolvidos, quais discursos defenderam sobre a medida, e como eles se articularam para buscar suas demandas. Sendo esses, então, os objetivos do artigo. Para nossos achados, utilizamos de dados secundários que foram analisados com base em categorias extraídas da Teoria do Discurso de Laclau e Mouffe (2015). Os resultados apontaram que a cadeia de equivalência formada entre Prefeitura e organizações da sociedade civil foi fundamental para a implementação da medida. E que ela gerou resultados positivos. Embora, a impopularidade dessa política pública ameace sua continuidade.
“Very strong” turnpike effect in a non-stationary Gale economy with investments, multilane turnpike and limit technology
Authors: Emil Panek
Published: December 2023

This article presents a multiproduct model of a non-stationary Gale-type economy  with  technology convergent to a certain limit technology, in which changes in the production technology  (the dynamics of the Gale production spaces) are ruled by the size of investments. Thus, the considered model differs from the vast majority of the Gale-type models  considered in the mathematical economy.  With this assumption,  the so-called “very strong” version of the multilane production turnpike theorem in the Gale economy with investments is proved. According to the theorem, if  the optimal growth process in such an economy reaches the multilane turnpike, it remains on it from then on, except for, possibly the last period of the analysed economic horizon.