bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase 1b study of isatuximab plus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma
Authors: Mikhael Joseph , Richardson Paul , Usmani Saad Z. , Raje Noopur , Bensinger William , Karanes Chatchada , Campana Frank , Kanagavel Dheepak , Dubin Franck , Liu Qianying , Semiond Dorothée , Anderson Kenneth
Published: March 2019

This phase 1b dose-escalation study evaluated isatuximab plus pomalidomide/dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM). Patients who had received ≥2 prior MM therapies, including lenalidomide and a proteasome inhibitor (PI), were enrolled and received isatuximab at 5, 10, or 20 mg/kg (weekly for 4 weeks, followed by every 2 weeks), pomalidomide 4 mg (days 1-21), and dexamethasone 40 mg (weekly) in 28-day cycles until progression/intolerable toxicity. The primary objective was to determine the safety and recommended dose of isatuximab with this combination. Secondary objectives included evaluation of pharmacokinetics, immunogenicity, and efficacy. Forty-five patients received isatuximab (5 [n = 8], 10 [n = 31], or 20 [n = 6] mg/kg). Patients received a median of 3 (range, 1-10) prior lines; most were refractory to their last regimen (91%), with 82% lenalidomide-refractory and 84% PI-refractory. Median treatment duration was 9.6 months; 19 patients (42%) remain on treatment. Most common adverse events included fatigue (62%), and upper respiratory tract infection (42%), infusion reactions (42%), and dyspnea (40%). The most common grade ≥3 treatment-emergent adverse event was pneumonia, which occurred in 8 patients (17.8%). Hematologic laboratory abnormalities were common (lymphopenia, leukopenia, anemia, 98% each; neutropenia, 93%; and thrombocytopenia, 84%). Overall response rate was 62%; median duration of response was 18.7 months; median progression-free survival was 17.6 months. These results demonstrate potential meaningful clinical activity and a manageable safety profile of isatuximab plus pomalidomide/dexamethasone in heavily pretreated patients with RRMM. The 10 mg/kg weekly/every 2 weeks isatuximab dose was selected for future studies. This trial was registered at www.clinicaltrials.gov as #NCT02283775.
Migration-based filtering: Applications to geophysical imaging data
Authors: Huo Jianjian , Zhou Binzhong , Zhao Qing , Mason Iain M. , Rao Ying
Published: March 2019

Migration is used to collapse “diffractions,” i.e., to focus hyperbolic events that appear in the space-time of a seismic profile — into spots of finite area in the image space. These usually represent scattering objects. However, there are situations in which some of the energy can be focused by migration, and muted without significantly damaging the remaining echoes. Demigration or forward modeling then restores the remaining data, and the removed signals can be rebuilt by subtracting these restored data from the original records. This process can be classified as migration-based filtering. It is demonstrated by synthetic and field data that this filter can be used for suppressing unwanted coherent signals or separating/extracting wavefields of interest: (1) the suppression of ground roll in seismic shot gathers, (2) the suppression of axially guided arrivals in borehole radar profiles, (3) suppressing the direct arrivals to enhance Stoneley-wave reflections in full-waveform sonic logging data, and (4) separating up- and downgoing waves in vertical seismic profiles.
Patient-Centered Preference Assessment to Improve Satisfaction With Care Among Patients With Localized Prostate Cancer: A Randomized Controlled Trial
Authors: Jayadevappa Ravishankar , Chhatre Sumedha , Gallo Joseph J. , Wittink Marsha , Morales Knashawn H. , Lee David I. , Guzzo Thomas J. , Vapiwala Neha , Wong Yu-Ning , Newman Diane K. , Van Arsdalen Keith , Malkowicz S. Bruce , Schwartz J. Sanford , Wein Alan J.
Published: March 2019

PURPOSE

To study the effectiveness of the Patient Preferences for Prostate Cancer Care (PreProCare) intervention in improving the primary outcome of satisfaction with care and secondary outcomes of satisfaction with decision, decision regret, and treatment choice among patients with localized prostate cancer.

METHODS

In this multicenter randomized controlled study, we randomly assigned patients with localized prostate cancer to the PreProCare intervention or usual care. Outcomes were satisfaction with care, satisfaction with decision, decision regret, and treatment choice. Assessments were performed at baseline and at 3, 6, 12, and 24 months, and were analyzed using repeated measures. We compared treatment choice across intervention groups by prostate cancer risk categories.

RESULTS

Between January 2014 and March 2015, 743 patients with localized prostate cancer were recruited and randomly assigned to receive PreProCare (n = 372) or usual care (n = 371). For the general satisfaction subscale, improvement at 24 months from baseline was significantly different between groups ( P < .001). For the intervention group, mean scores at 24 months improved by 0.44 (SE, 0.06; P < .001) from baseline. This improvement was 0.5 standard deviation, which was clinically significant. The proportion reporting satisfaction with decision and no regret increased over time and was higher for the intervention group, compared with the usual care group at 24 months ( P < .05). Among low-risk patients, a higher proportion of the intervention group was receiving active surveillance, compared with the usual care group ( P < .001).

CONCLUSION

Our patient-centered PreProCare intervention improved satisfaction with care, satisfaction with decision, reduced regrets, and aligned treatment choice with risk category. The majority of our participants had a high income, with implications for generalizability. Additional studies can evaluate the effectiveness of PreProCare as a mechanism for improving clinical and patient-reported outcomes in different settings.
TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases
Authors: Freedman Rachel A. , Gelman Rebecca S. , Anders Carey K. , Melisko Michelle E. , Parsons Heather A. , Cropp Anne M. , Silvestri Kelly , Cotter Christine M. , Componeschi Kathryn P. , Marte Juan M. , Connolly Roisin M. , Moy Beverly , Van Poznak Catherine H. , Blackwell Kimberly L. , Puhalla Shannon L. , Jankowitz Rachel C. , Smith Karen L. , Ibrahim Nuhad , Moynihan Timothy J. , O’Sullivan Ciara C. , Nangia Julie , Niravath Polly , Tung Nadine , Pohlmann Paula R. , Burns Robyn , Rimawi Mothaffar F. , Krop Ian E. , Wolff Antonio C. , Winer Eric P. , Lin Nancy U. ,   on behalf of the Translational Breast Cancer Research Consortium
Published: March 2019

PURPOSE

Evidence-based treatments for metastatic, human epidermal growth factor receptor 2 (HER2)–positive breast cancer to the CNS are limited. We previously reported modest activity of neratinib monotherapy for HER2-positive breast cancer brain metastases. Here we report the results from additional study cohorts.

PATIENTS AND METHODS

Patients with measurable, progressive, HER2-positive brain metastases (92% after receiving CNS surgery and/or radiotherapy) received neratinib 240 mg orally once per day plus capecitabine 750 mg/m2 twice per day for 14 days, then 7 days off. Lapatinib-naïve (cohort 3A) and lapatinib-treated (cohort 3B) patients were enrolled. If nine or more of 35 (cohort 3A) or three or more of 25 (cohort 3B) had CNS objective response rates (ORR), the drug combination would be deemed promising. The primary end point was composite CNS ORR in each cohort separately, requiring a reduction of 50% or more in the sum of target CNS lesion volumes without progression of nontarget lesions, new lesions, escalating steroids, progressive neurologic signs or symptoms, or non-CNS progression.

RESULTS

Forty-nine patients enrolled in cohorts 3A (n = 37) and 3B (n = 12; cohort closed for slow accrual). In cohort 3A, the composite CNS ORR = 49% (95% CI, 32% to 66%), and the CNS ORR in cohort 3B = 33% (95% CI, 10% to 65%). Median progression-free survival was 5.5 and 3.1 months in cohorts 3A and 3B, respectively; median survival was 13.3 and 15.1 months. Diarrhea was the most common grade 3 toxicity (29% in cohorts 3A and 3B).

Neratinib plus capecitabine is active against refractory, HER2-positive breast cancer brain metastases, adding additional evidence that the efficacy of HER2-directed therapy in the brain is enhanced by chemotherapy. For optimal tolerance, efforts to minimize diarrhea are warranted.
Reliable imaging of ATP in living budding and fission yeast
Authors: Takaine Masak , Ueno Masaru , Kitamura Kenji , Imamura Hiromi , Yoshida Satoshi
Published: March 2019

Adenosine triphosphate (ATP) is a main metabolite essential for all living organisms. However, our understanding of ATP dynamics within a single living cell is very limited. Here, we optimized the ATP-biosensor QUEEN and monitored the dynamics of ATP with good spatial and temporal resolution in living yeasts. We found stable maintenance of ATP concentration in wild-type yeasts, regardless of carbon sources or cell cycle stages, suggesting that mechanism exists to maintain ATP at a specific concentration. We further found that ATP concentration is not necessarily an indicator of metabolic activity, as there is no clear correlation between ATP level and growth rates. During fission yeast meiosis, we found a reduction in ATP levels, suggesting that ATP homeostasis is controlled by differentiation. The use of QUEEN in yeasts offers an easy and reliable assay for ATP dynamicity and will answer several unaddressed questions about cellular metabolism in eukaryotes.
Environmentalism with Chinese Characteristics—A Review of Matthew E. Kahn and Siqi Zheng’s Blue Skies over Beijing: Economic Growth and the Environment in China
Authors: Coxhead Ian
Published: March 2019

China’s dramatic rise from poverty to global economic prominence has been accompanied by an equally dramatic increase in environmental damages. The book under review presents an exploration of economic and political economy factors that might bring about a reversal in emissions that contribute to high pollution loadings in large urban areas. The authors highlight preference shifts associated with rapid growth of per capita income and express optimism about government responses to demands for a cleaner environment. There are some indications that China’s largest cities are indeed getting cleaner air. However, total emissions (largely from heavy industry and coal-fired energy generators) continue to rise, and the mechanisms by which preference shifts turn into policy changes remain opaque. It may be that China’s most polluting industries are sorting into localities where either preferences for clean air are less pronounced or local governments are less responsive. This may match a positively selected counterflow of individuals seeking better environmental amenities and more responsive government. (JEL O13, O44, P28, Q53, Q56, Q58)
Attitudes of faculty and residents of surgical specialties towards professionalism at a tertiary care hospital of Islamabad
Authors: Manzoor Arifa , Baig Lubna Ansari , Aly Syed Moyn
Published: March 2019

Objectives: To determine the attitudes of faculty and residents of surgical specialties towards professionalism and to test the validity and reliability of a tool developed in USA for Pakistan.

Methods: An exploratory validation study was carried out at Pakistan Institute of Medical Sciences (PIMS), Islamabad from 01-Aug-2016 to 31-Jan-2017. Penn State College of Medicine Professionalism Questionnaire (PSCOM) was used, being a reliable and valid survey tools. Exploratory Factor Analysis of the inter-correlations of responses for 36 items was done using SPPS v 21 to give a factor solution to reflect the perceptions regarding attitudinal elements.

Results: There were 209 respondents including 172 residents and 37 faculty members. Response rate was 81.32%. Exploratory Factor Analyses of responses gave a seven factor solution of professionalism: accountability, honour and integrity, excellence, duty, altruism, equity and respect. Six of the factors that emerged reflect the six elements of professionalism reported by American Board of Internal Medicine (ABIM), except for ‘equity’, which was the new factor that emerged. Cronbach’s alpha (Internal Consistency Reliability) for each element of professionalism was between 0.88-0.98.

Conclusion: PSCOM is a valid, reliable, feasible and acceptable tool to assess attitudes of faculty and residents towards professionalism in Pakistan. ‘Equity’ emerged as a new factor which needs to be studied further.

How to cite this:Manzoor A, Baig LA, Aly SM. Attitudes of faculty and residents of surgical specialties towards professionalism at a tertiary care hospital of Islamabad. Pak J Med Sci. 2019;35(2):371-376. doi: https://doi.org/10.12669/pjms.35.2.387

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparison of serum levels of vitamin D and vitamin D-binding protein in normal, osteopenic and osteoporotic postmenopausal women
Authors: Murad Rafat , Mahboob Tabassum , Rehman Rehana , Baig Rozeena
Published: March 2019

Objective: To compare the serum levels of vitamin D, vitamin D binding protein (VDBP) calcium and phosphate in normal, osteopenic and osteoporotic postmenopausal women categorized on the basis of bone mineral density (BMD) scores.

Methods: A cross sectional study carried out from May 2017 to August 2018. BMD measured by Dual energy X-ray Absorptiometry categorized women (aged 20- 70 years) into normal (n=37) (T score ≥ -1.0) osteopenic (n=25) (-2.5< T score, < -1) and osteoporotic (n= 26) (T score < -2.5) according to WHO classification. Serum concentrations of vitamin D, VDBP, calcium, phosphate analyzed by enzyme linked immunosorbent assay were compared by Analysis of Variance

Results: In normal females higher levels of vitamin D and VDBP were observed [15.82 (8 - 69.18), 469.9 (269.57 - 875.55)] vs. osteopenic [(7.45 (4.66 - 15.1), 296.05 (232.58 - 420.23)] and osteoporotic women [(7.25 (3.97 - 17.49), 272.94 (202.23 - 351.24)]; [median interquartile range]; p value < 0.0001.

Conclusion: Vitamin D and VDBP are linked with bone health and estimation of VDBP appears to be a valuable tool for the assessment of increased bone loss and possible risks of bone fractures especially in postmenopausal women.

How to cite this:Murad R, Mahboob T, Rehman R, Baig R. Comparison of serum levels of vitamin D and vitamin D-binding protein in normal, osteopenic and osteoporotic postmenopausal women. Pak J Med Sci. 2019;35(2):543-548. doi: https://doi.org/10.12669/pjms.35.2.714

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
THE STUDY OF ATMOSPHERE. MAIN METEOROLOGICAL ELEMENTS: ECOLOGICAL AND CLIMATIC VALUE AND MEASUREMENT METHODS
Authors: Алексеева Любовь , Alekseeva Lyubov' , Мягков Михаил , Myagkov Mihail , Семёнов Евгений , Semenov Evgeniy , Соколихина Наталья , Sokolihina Natal'ya
Published: March 2019

The manual describes main meteorological elements as the main environmental factors. Tasks for self-study at the end of each Chapter help students to form knowledge base and skills of processing and analysis of meteorological information, they are necessary to solve actual problems of ecology, including the problem of environment and atmospheric air protection issues.
Limitations of Using Pediatric Respiratory Illness Readmissions to Compare Hospital Performance
Authors: Kaiser Sunitha V. , Lam Regina , Joseph Gabby B. , McCulloch Charles , Hsia Renee Y. , Cabana Michael D. , Bardach Naomi S.
Published: March 2019

BACKGROUND

Adult hospital readmission rates can reliably identify meaningful variation in hospital performance; however, pediatric condition‐specific readmission rates are limited by low patient volumes.

OBJECTIVE

To determine if a National Quality Forum (NQF)‐endorsed measure for pediatric lower respiratory illness (LRI) 30‐day readmission rates can meaningfully identify high‐ and low‐performing hospitals.

DESIGN

Observational, retrospective cohort analysis. We applied the pediatric LRI measure and several variations to evaluate their ability to detect performance differences.

SETTING

Administrative claims from all hospital admissions in California (2012‐2014).

PATIENTS

Children (age <18 years) with LRI (primary diagnosis: bronchiolitis, influenza, or pneumonia; or LRI as a secondary diagnosis with a primary diagnosis of respiratory failure, sepsis, bacteremia, or asthma).

MEASUREMENTS

Thirty‐day hospital readmission rates and costs. Hierarchical regression models adjusted for age, gender, and chronic conditions were used.

RESULTS

Across all California hospitals admitting children (n = 239) using respiratory readmission rates, no outlier hospitals were identified with (1) the NQF‐endorsed metric, (2) inclusion of primary asthma or secondary asthma exacerbation diagnoses, or (3) inclusion of 30‐day emergency revisits. By including admissions for asthma, adding emergency revisits, and merging 3 years of data, we identified 9 outlier hospitals (2 high‐performers, 7 low‐performers). There was no association of hospital readmission rates with costs.

CONCLUSIONS

Using a nationally‐endorsed quality measure of inpatient pediatric care, we were unable to identify meaningful variation in hospital performance without broadening the metric definition and merging multiple years of data. Utilizers of pediatric‐quality measures should consider modifying metrics to better evaluate the quality of pediatric care at low‐volume hospitals.
Fungal diseases at the medical front door
Authors: Wilson Aline , Wilkie Morven , Rae Nikolas
Published: March 2019

Fungal diseases are an increasingly recognized cause of mortality worldwide and often pose diagnostic challenges. This article focuses on common fungal diseases as they may present in the acute medical unit, looking at the initial investigation and management of four common diseases: Pneumocystis jirovecii pneumonia, cryptococcal meningitis, candidaemia and allergic bronchopulmonary aspergillosis. There is an increase in morbidity and mortality if these conditions are not correctly diagnosed and thus appropriate therapy is delayed. A better understanding of the initial investigation and management of these conditions will improve the outcome of patients with fungal diseases presenting to the ‘medical front door’.
All about … Rough and tumble
Authors: Russell Meredith Jones
Published: March 2019

Why does rough and tumble play benefit children and how can practitioners enable it in a positive and safe way? Meredith Jones Russell reports
Ex vivo model for a new bilateral antimesenteric V-modified side-to-side isoperistaltic anastomosis to prevent recurrence in ileocolic Crohn’s disease
Authors: Celentano V , Luvisetto F , Toh S
Published: March 2019

Introduction

The high rate of recurrence following ileocaecal resection for Crohn’s disease may lead to repeat surgery in 20–30% of patients at five years after surgery. Recurrence usually occurs at the anastomosis and the neoterminal ileum and the association of a strictureplasty to widen the bowel lumen in the regions immediately proximal (‘anastomotic inlet’) and distal (‘anastomotic outlet’) to the anastomosis may delay or reduce the risk of surgical recurrence.

Materials and methods

A side to side isoperistaltic anastomosis, with an associated V-modified strictureplasty on the anti-mesenteric border at the level of the anastomosis inlet and outlet has been designed. We produced a wet lab ex vivo model of the anastomosis and, to evaluate the different calibre of the anastomotic segments, we compared it with ex vivo models of three anastomotic configurations currently used in surgery for Crohn’s disease: i) side to side isoperistaltic anastomosis; ii) modified side-to-side isoperistaltic anastomosis with double Heineke–Mikulicz procedure (Sasaki anastomosis); iii) anti-mesenteric functional end-to-end handsewn anastomosis (Kono-S anastomosis).

Results

Differences were recorded at the level of the anastomosis inlet and outlet, with a larger volume estimated in the Sasaki anastomosis and in the V-modified anastomosis. The V-modified anastomosis had a larger volume compared with the Sasaki anastomosis for a longer segment of small bowel.

Conclusions

We have developed an experimental animal model for a new anastomotic technique which could be applied in surgery for Crohn’s disease following small-bowel or ileocolic resection.
Management of ‘low-risk’ ankle fractures in children: a systematic review
Authors: Marson BA , Ng J , Myint Y , Grindlay DJC , Ollivere BJ
Published: March 2019

Introduction

This study aimed to review the literature to establish whether there is a best treatment for low-risk ankle fractures in children.

Materials and methods

A systematic review and meta-analysis of trials was undertaken, which compared interventions for ‘low-risk’ ankle fractures in children. A meta-analysis was performed using a random effects model.

Results

Four trials were identified reporting outcomes from 256 patients. All trials reported results using a device that permitted ankle motion compared with more rigid immobilisation. Overall risk of bias was low for three trials and high for one trial. Two trials assessed time to return to normal function. Patients treated in a splint or with a bandage recovering 6–7.5 days sooner than those treated with rigid immobilisation. One trial demonstrated that children returned to school sooner if treated in a bandage rather than in a cast. Two trials found a higher Activity Scale for Kids performance score at four weeks for children treated with splint compared with rigid immobilisation. There was no clear advantage to any device in patient satisfaction, quality of life or total costs.

Discussion

There is no clear best treatment for these injuries. Studies had significant limitations and outcomes were heterogeneous, limiting meta-analysis.

Conclusion

There is a need for a definitive trial to establish the best treatment for ankle fractures and a core outcome set to ensure study findings are consistent and can be analysed in future meta-analyses.
Clinical investigation of back disorders in horses: A retrospective study (2002-2017)
Authors: Mayaki Abubakar Musa , Intan-Shameha Abdul Razak , Noraniza Mohd Adzahan , Mazlina Mazlan , Adamu Lawan , Abdullah Rasedee
Published: March 2019

Background and Aim: Back disorder is an ailment that often affects athletic and riding horses. Despite the rapidly growing equine athletic and equestrian activities, there is no documentation on the nature of equine back disorder (EBD) in Malaysian horses. The purpose of this study was to characterize EBD cases presented to University Veterinary Hospital, Universiti Putra Malaysia, between 2002 and 2017.

Materials and Methods: The compilation of data was based on signalment, case history, duration of clinical signs, anatomical location of the pain, method of diagnosis, type of EBD, treatment, and outcome. The diagnosis of EBD was based on a history of poor performance, clinical examination findings, radiography, and, where applicable, necropsy.

Results: A total of 181 diagnosed cases of EBDs were identified. The age of horses ranged from 5 to 22 years. The EBD cases were more prevalent in male than female horses and predominantly in geldings (60.77%). Thoroughbred, Arab, Polo pony, and Warmblood also recorded the most EBD cases among breeds. The discipline of horses tended to influence the development of EBDs, with patrolling horses recording the highest frequency. Most EBD cases were of the primary type (92.27%), with the main causes being soft-tissue lesions (57.48%), vertebral lesions (18.56%), tack-associated problems (16.77%), and neurological lesions (7.19%). The common treatments employed were administration of nonsteroidal anti-inflammatory agents, 1 to 3-month rest, warm and cold compression therapy, massage therapy, exercise adjustment, as well as correction of ill-saddle fit.

Conclusion: Most EBDs in this study were associated with soft-tissue lesions. Among vertebral lesions, kissing spines were the most common cause of EBDs in horses in Malaysia.
Scars, The Surgeons’ Overlooked Threat From Hero to Zero
Authors: Perdanakusuma David S
Published: March 2019

Scar is a reminding mark left by surgeons on patients who presented with wounds or required surgery. In healing process, due to some circumstances and individual traits, wounds could become bad scars that would definitely affect the patient’s appearance and cause many complaints. In the first years after treatment, surgeons will be commemorated as heroes who once helped the patients to overcome and cure the disease. After a few years, the memory of the surgeon’s heroic action will gradually dissipate with the formation of a bad scar. Such good memory will be replaced with persistent complaints arising from the scar such as deformity, pain, itchiness and enlargement of the lesion. Several efforts have been made to manage disturbing scars however they often do not yield satisfactory result and moreover sometimes the scars will enlarge, become unpleasant and more disturbing. This will frustrate the patient as well as the surgeon. The good memory of the surgeon as a hero has shifted into one whose surgical procedure was regretted. Presently, there are about 25 modalities using various approaches for scar treatment. These manifold choices indicate that the available modalities have been generally inadequate and the therapeutic response very variable. Furthermore, treatment selection is also based on recurrence. Most of the available therapeutic modalities in this stage are nonsurgical. There is also topical treatment mostly containing herbal extract, which is considered inadequate and lacking of evidence base. Corticosteroid injection and silicone gel is a nonsurgical method recommended and supported by evidence based. This technique is largely chosen by doctors. Combined therapy is the method of choice believed to yield optimal result. Let us remain heroes by paying attention to scars.
A verbális munkamemória fejlődésének vizsgálata 5 éves kortól 85 éves korig
Authors: Juhász Dóra
Published: March 2019

A munkamemória fejődésének vizsgálata nagy relevanciával bír, mind az oktatásban, mind a kognitív tudományok terén. A munkamemória olyan rövidtávú emlékezet, mely az információt rövid ideig (néhány másodperc, vagy perc) megtartja, illetve az információt manipulálja. A munkamemória alegységei közül a fonológiai hurok, más néven verbális munkamemória nagysága jól bejósolja az egyén nyelvelsajátítási képességeit, legyen szó akár az anyanyelvről, akár idegen nyelvről. Az eddigi szakirodalmak alapján a verbális munkamemória kapacitása 7, legkésőbb 10 éves korra kialakul, és fejlődési ívét tekintve fordított U alakot mutat. Mivel a legtöbb szakirodalom külön vizsgálja az egyes életkori csoportokat, jelen kutatás célja a verbális munkamemória fejlődésének vizsgálata egy kutatáson belül az egyes életkorokban. E terület mérésére a Számterjedelem Teszt, Hallási Mondatterjedelem Teszt, a Számlálási Terjedelem Teszt, a Betű Fluencia, Szemantikus Fluencia, valamint a Cselekvés Fluencia Tesztek kerültek felvételre. A vizsgálatban 380 fő vett részt, 10 életkori csoportra bontva. Eredményeink szerint a verbális munkamemória kapacitását reprezentáló fejlődési görbe fordított U alakot mutat, tehát ezen kognitív funkciók gyerekkorban folyamatosan fejlődnek, felnőttkorban érik el a csúcspontot, majd idős korban fokozatosan hanyatlást mutatnak. Jelen kutatás egészen korai életkortól az aggkorig vizsgálódik, mely segítségül szolgálhat a verbális munkamemória életkori sajátosságainak alaposabb feltérképezéséhez, tanulmányozásához.
Effect of different root dentin pretreatment protocols on the bond strength of fiber posts cemented with core buildup material
Authors: Naeem Rowaida , Zohdy Maged , Salah Tarek
Published: March 2019

Objective: The purpose of the study was to evaluate the push out bond strength of fiber posts -after cementaion with core build up material and dentin pretreatment using different adhesive protocols- in different root regions. Material and Methods: 28 endodonticaly treated human premolars were divided into 4 groups. The post spaces were treated with 1 of 4 different dentin bonding protocols: total etch light cured adhesive, solobond m; total etch dual cured adhesive, Excite f DSC; self-etching light cured adhesive, single bond universal; or self-etching dual cured adhesive, futura bond dc. Fiber posts, were luted with dual cured core material. The roots were cut into 2-mm-thick sections, in cervical, middle, and apical regions. Push-out tests were performed with a universal testing machine, and bond strength values (MPa) were calculated. Data were analyzed with 1- and 2-way analysis of variance and Tukey multiple comparison tests (a=.05). Failure modes were examined under stereo microscope. Results: The highest mean bond strength values were obtained for self-etch dual cured adhesive, (9.69 MPa). The Total etch light cured adhesive (2.81 MPa) showed the lowest bond strength. Self-etch light-polymerized and total etch dual-polymerized adhesives provided similar bond strengths (5.37, 5.72 respectively). The regional bond strength values were reduced significantly in apical post space (P<0.01). The most predominant failure type was mixed failure followed by adhesive failure. Conclusion: Dentin pretreatment using self-etch dual cured adhesives prior to fiber posts cementation offers a high bond strength. While using total-etch light cured adhesives is not recommended due to the low bonding quality. KeywordsDentin; Bond strength; Fiber posts; Core buildup material; Adhesive protocols; Pretreatment.
Microleakage of high viscosity glass-ionomer and glass-carbomer with and without coating before and after hydrothermal aging
Authors: Patır Münevveroğlu Asli , Ozsoy Alev , Ballı akgol Beyza , Bozatlioglu Ruhan , Korkut Pelin , Uysal Busra , Ozcan Mutlu
Published: March 2019

Objective: The objective of this study was to evaluate the microleakage patterns of GIC and GGC with and without their protective surface coatings on enamel and dentin margins before and after aging. Material and Methods: Two rectangular cavities (height: 2 mm; width: 3 mm; depth: 1.5 mm) were prepared on each tooth at the cemento-enamel junction were prepared on human permanent molars (N=56) and the teeth were randomly assigned to be restored with one of the following: a) high viscosity glass-ionomer cement (GIC) (EQUIA Fil, C Corp., Tokyo, Japan) (n=28), b) glass-carbomer cement (GCC) (Glass Carbomer Products, Leiden, The Netherlands) (n=28). Half of the teeth were further divided into two groups where one group received protective surface coating (SC) (G-Coat Plus, GC Corp) (n=14) and the other group did not (n=14). Half of the teeth were stored for 24 hours (n=7), and the other half was thermocycled (5000 cycles, 5-55°C) (n=7). For microleakage analysis, the teeth were immersed in 5% methylene blue dye for 24 hours, sectioned into two equal halves. Microleakage patterns were evaluated using stereomicroscope and scored on a scale of 0-3 (0: No dye penetration, 1: Dye penetration less than half of the axial wall, 2: Dye penetration more than half the axial wall, 3: Dye penetration spreading along the axial wall). Data were analyzed using Kruskal-Wallis tests at the significance level of 0.05. Results: Compared to 24 h storage, after thermocycling, surface coating on GIC decreased microleakage significantly compared to GCC (p=0.046) but not for GCC. In the thermocycled groups, coated GIC showed significantly less leakage at the enamel margin but no significant difference was found with both GIC and GCC in the dentin margins. Conclusion: The application of surface coating significantly reduced the microleakage scores of GIC but not GCC, within the enamel margins only.KeywordsGlass-carbomer; Glass-ionomer; Microleakage.
PARTICLE MOTION OVER THE EDGE OF AN INCLINED PLANE THAT PERFORMS AXIAL MOVEMENT IN A VERTICAL LIMITING CYLINDER
Authors: Pylypaka Serhii F. , Klendii Mykola B. , Nesvidomin Viktor M. , Trokhaniak Viktor I.
Published: March 2019

Differential equations of a relative material particle motion over the edge of an inclined flat ellipse that rotates around the axis of a vertical limiting cylinder have been deduced. The position of a plane relative to the axis of the rotation is set by the angle ranging from zero to ninety degrees in its value. If the angle is equal to zero, the plane is perpendicular to the axis of rotation and if the angle is equal to ninety degrees, it passes through the axis of rotation. The equations have been solved using numerical methods. Analytical solution has been found for certain angles. The aim of the research is to investigate the transportability of a technological material in a vertical direction by a cascade operating element that rotates in a cylindrical cover. The working part of the operating element is an inclined rigid plane, which is limited by an ellipse — the line of its contact with a cover. The objective of the research is to analytically describe the movement of a single particle of the technological material on two surfaces, namely, an inclined plane and a vertical cover. The research methodology is based on the methods of differential geometry and the theory of surfaces, theoretical mechanics and numerical methods of solving differential equations. The paper presents a first developed analytical description of the relative particle motion in an ellipse — a contact line of an inclined plane and a limiting vertical cylinder, in which the inclined plane rotates. The kinematic characteristics of such motion have been determined.
O passado prático
Authors: White Hayden
Published: March 2019

Tradução: Arthur Lima de Avila*, Mario Marcello Neto**, Felipe Radünz Krüger***
(Re)Politizando a teoria da história em tempos de exceção: Hayden White e a crítica do presente
Authors: De Avila Arthur Lima
Published: March 2019

Este ensaio busca discutir algumas possibilidades para uma teoria da história engajada com os problemas de nosso tempo, a partir de certas colocações de Hayden White. Nesse sentido, o texto oferece determinadas perspectivas para – nesta conjuntura que combina a consolidação de racionalidades neoliberais, a ampliação de necropolíticas contra populações específicas e a ascensão de movimentos e modos de governos fascistoides – um reposicionamento da teoria da história como uma crítica do presente.
Artes tradicionais do fazer: alimentos e patchwork em tramas
Authors: Abdala Mônica Chaves , Da Silva Cristiane Aparecida Fernandes , Papavero Claude G.
Published: March 2019

A proposta desta discussão é compreender aspectos da cultura e da sociedade brasileiras por meio de duas expressões tradicionais das artes do fazer, a culinária e a arte têxtil, unidas em telas de patchwork. Empreendeu-se uma investigação de cunho qualitativo para analisar telas da Exposição “Brasil, cheiros, temperos e sabores”, da 10ª Brazil Patchwork Show, realizada em 2016 em São Paulo. Identificou-se nessas obras a representação de alimentos provenientes de diferentes regiões do país. Tratava-se de alusões pictóricas a hábitos e costumes locais que subentendiam saberes e práticas culturais e possibilitavam identificar a riqueza simbólica do universo figurado. A diversidade dos aromas e sabores de gêneros comestíveis retratados confirmou, portanto, a hipótese inicial da relevância dos alimentos representados para compreender aspectos socioculturais do Brasil.

palavras-chave: alimento; arte; culturas.
A obra-prima impossível: uma leitura do tema da idealização e fracasso na arte
Authors: Lima Andrei Fernando Ferreira
Published: March 2019

No discurso literário do século XIX, a idealização surge como um tema e um tópico metapoético capaz de ensejar importante reflexão sobre o sentido da criação artística, seus desafios e limites, bem como sobre as relações retóricas entre realidade e representação. Nesse contexto, diversas narrativas se ocupam do assunto, sendo uma das mais célebres A obra-prima ignorada (1831), de Honoré de Balzac, que toma a pintura como referencial para desenvolver uma representação emblemática do artista empenhado em uma busca obsessiva pela perfeição, estabelecendo certas perspectivas que se aproximam. Neste artigo, veremos, então, a partir da elaboração balzaquiana, como outros textos, a exemplo de A Madona do futuro (1873), de Henry James, e do relato “Paolo Uccello”, do livro Vidas imaginárias (1896), de Marcel Schwob, se inserem nessa dinâmica e que implicações conceituais e formais trazem à linguagem e ao imaginário.

palavras-chave: idealização; arte; narrativa.
A biografia como espaço de poder, caminho de saber e campo de possibilidades
Authors: Silva Wilton C. L.
Published: March 2019

AVELAR, Alexandre de Sá e SCHIMDT, Benito Bisso. O que pode a biografia. São Paulo: Letra e Voz, 2018, 242 p.
The Mixed CUSUM-EWMA (MCE) control chart as a new alternative in the monitoring of a manufacturing process
Authors: Alves Custodio Da Cunha , Konrath Andréa Cristina , Henning Elisa , Walter Olga Maria Formigoni Carvalho , Paladini Edson Pacheco , Oliveira Teresa A. , Oliveira Amílcar
Published: March 2019

Goal: The objective is to conclude, based on a comparative study, if there is a significant difference in sensitivity between the application of MCE and the individual application of the CUSUM or EWMA chart, i.e., greater sensitivity particularly for cases of lesser magnitude of change.

Design/Methodology/Approach: These are an applied research and statistical techniques such as statistical control charts are used for monitoring variability. Results: The results show that the MCE chart signals a process out of statistical control, while individual EWMA and CUSUM charts does not detect any situation out of statistical control for the data analyzed.

Limitations: This article is dedicated to measurable variables and individual analysis of quality characteristics, without investing in attribute variables. The MCE chart was applied to items that are essential to the productive process development being analysed.

Practical Implications: The practical implications of this study can contribute to: the correct choice of more sensitive control charts to detect mainly small changes in the location (mean) of processes; provide clear and accurate information about the fundamental procedures for the implementation of statistical quality control; and encourage the use of this quality improvement tool.

Originality/Value: The MCE control chart is a great differential for the improvement of the quality process of the studied company because it goes beyond what CUSUM and EWMA control charts can identify in terms of variability.
Procedure for identifying factors and interfaces that are critical in a sustainable product
Authors: Carísio de Paula Istefani , Hoppe Daniel Augusto , Marx Ângela Maria , Van der Linden Julio Carlos de Souza
Published: March 2019

Goal: To test a systematic procedure for identifying critical factors and interfaces among the stakeholders involved with the lifecycle of a sustainable product, with a view to make design prioritizations.

Design/Methodology/Approach: A qualitative-quantitative approach including interviews and requirements analysis led to the definition of relationships in network graphical representations. Stakeholders from hygiene and cleaning products (HCP) manufacturing and consumption segment were interviewed in the state of Rio Grande do Sul, Brazil.

Results: Factors and interfaces that are critical for a sustainable system were highlighted by the procedure and they include: human resources training, research funding, waste collection systems, and people's behavior towards product discarding.

Limitations of investigation: This is an exploratory study performed in a single segment: the hygiene and cleaning products (HCP).

Practical implications: The understanding of the behavior of professionals in the hygienic product-manufacturing segment.

Originality/value: To explore a new way for identification of critical elements in a sustainable network system.
Computer Simulation Model for Outpatient Clinics in a Brazilian Large Public Hospital Specialized in Cardiology
Authors: Chang Junior João , Lima Fábio , Fernandes Alfredo Manoel da Silva , Guardia Felipe De Almeida , Da Silva Vanessa Dias , Maccheri Giovanni Augusto
Published: March 2019

Goal: the main objective of this study is to analyze the behavior of the outpatient department of a large public hospital specialized in cardiology, understanding how the components of this system are related, in order to improve the hospital’s performance.

Design / Methodology / Approach: a case study was carried out in a public hospital specializing in cardiology with the aid of Modeling and Simulation of System Dynamics.

Results: the result showed that variables such as doctor availability and average consultation time have great influence on the service capacity.

Limitations of the investigation: the proceedings and times related to the medical staff are particular to each team and they are not standardized. However, in the system dynamics modeling these particularities cannot be included.

Practical implications: for theory, there is the state-of-the-art development in terms of how to manage and regarding the methodologies should be applied in a complex referential model composed of several moderating variables, in order to obtain the best use of the available resources (human and material) of the hospital. For practice, the flow of patients in the hospital should be predicted and optimized, adding value to the services provided to its users.

Originality / Value: the originality of the work is based on the unprecedented application of quantitative methods for solving problems in Brazilian hospitals.
A multilinear interaction model: algorithms for Kalai-Smorodinsky solution
Authors: Donato Alessia
Published: March 2019

We implement Matlab algorithms for the construction and representation of the payoff space in a certain applicable game models, in 2 and 3 dimensions. More- over our algorithms can find the Kalai-Smorodinsky solutions in the same game with some interfering elements. We write down the intersection of the critical zone and the Kalai-Smorodinsky straight-line for finding the compromise solution. We propose a software for the determination of the graphs. In the Appendix we solve the problem in closed form for the 2 and 3 dimensional case and numerical ly for n = 7.
Economics versus Psychology. Risk, Uncertainty and the Expected Utility Theory
Authors: Schilirò Daniele
Published: March 2019

The present contribution examines the emergence of expected utility theory by John von Neumann and Oskar Morgenstern, the subjective the expected utility theory by Savage, and the problem of choice under risk and uncertainty, focusing in particular on the seminal work “The Utility Analysis of Choices involving Risk” (1948) by Milton Friedman and Leonard Savage to show how the evolution of the theory of choice has determined a separation of economics from psychology.
Technological paradigms and innovation
Authors: Donato Alessia
Published: March 2019

In this brief lecture notes, we consider the concepts of technologicalparadigm and technological trajectory introduced by Dosi in 1982 and we analyze the possible roles of firms in the innovation process according to the ”technology push" and ”demand pull" innovation models.
The effects of visual art supported inquiry based science activities on 5th grade students’ scientific process skills
Authors: Kar Hazel , Çil Emine
Published: March 2019

The study aimed to investigate the effects of visual art supported inquiry based science education on 5th grade students’ scientific process skills (SPS). In the research, one group pretest-posttest experimental design is used. The study was carried out with the help of 20 5th grade students. For the purpose of the research, an education including inquiry based activities (IBA) and visual art based activities (VABA) was designed and applied. The education applied during this study contains 7 IBAs, 5 VABAs. Qualitative and quantitative data were collected during this implementation. While the quantitative data was gathered by SPS Test, the qualitative data was gathered by unstructured observations. For analyzing the data gathered by SPS Test, Wilcoxon Signed Rank Test was used. For analyzing the unstructured observation data, content analysis was used. Based on the data gathered from the study, it can be said that visual art supported inquiry based science education contributes to improve students’ observation, inference, determining variables and designing experiment skills, while it contributes limitedly to improve comparison-classification, prediction, estimation, measuring, collecting knowledge and data, data processing and forming a model and interpreting data skills. It does not, however, contribute to improve recognizing and using experiment materials and instruments, recording data and presentation skills.
ATP-Binding Cassette transporters' gene expression in pediatric patients with acute leukemia; a comprehensive analysis of published reports through PubMed search engine
Authors: Mehrvar Narjes , Akbari Mohammad Esmail , Rezvany Mohammad Reza , Abolghasemi Hasan , Saberynejad Javad , Mehrvar Azim , Faranoush Mohammad , Keramatinia Ali Asghar , Shekarriz-Foumani Reza , Movafagh Abolfazl
Published: March 2019

Multidrug resistance based on ABC transporters' gene expression is one of the most important health challenges through chemotherapy of patients. This resistance can cause relapse or treatment failure. The goal of this conducted study was to evaluate the results of published reports which considered ABC transporters' gene expression in pediatric patients with acute leukemia. PubMed as a free search engine was chosen. The following Mesh terms were used as: "ATP-binding cassette transporters” OR "ABC-transporters*” AND "gene expression*” AND "leukemia” OR "ALL” OR "AML” OR "acute leukemia*”. Age was set as an additional filter with the age range of birth to 18 years old. Initial screening was performed according to inclusion and exclusion criteria and the quality of the selected papers was assessed. Papers categorized into three sections as: pediatric patients with ALL (6 papers from 1998-2015); pediatric patients with AML (3 papers from 1992-2011) and pediatric patients with ALL and AML (7 papers from 1992-2014). Totally 1118 patients enrolled in the searched studies (ALL and AML: 488; ALL: 405; AML: 225). The common method for evaluating gene expression of ABC transporters was RT-PCR. More than 50% of the papers showed the influence of ABC transporters' gene expression on prognosis and treatment failures of patients. Despite controversial results, the gathered information in the current report serves as a comprehensive referential resource, which can be beneficial for future planning around this title, especially in developing countries.