bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Charging Pad Deployment by Applying a Quad-Tree Scheme
Authors: Cheng Rei-Heng , Yu Chang-Wu , Zhang Zuo-Li
Published: June 2024

The recent advancement in wireless power transmission (WPT) has led to the development of wireless rechargeable sensor networks (WRSNs), since this technology provides a means to replenish sensor nodes wirelessly, offering a solution to the energy challenges faced by WSNs. Most of the recent previous work has focused on charging sensor nodes using wireless charging vehicles (WCVs) equipped with high-capacity batteries and WPT devices. In these schemes, a vehicle can move close to a sensor node and wirelessly charge it without physical contact. While these schemes can mitigate the energy problem to some extent, they overlook two primary challenges of applied WCVs: off-road navigation and vehicle speed limitations. To overcome these challenges, previous work proposed a new WRSN model equipped with one drone coupled with several pads deployed to charge the drone when it cannot reach the subsequent stop. This wireless charging pad deployment aims to deploy the minimum number of pads so that at least one feasible routing path from the base station can be established for the drone to reach every SN in a given WRSN. The major weakness of previous studies is that they only consider deploying a wireless charging pad at the locations of the wireless sensor nodes. Their schemes are limited and constrained because usually every point in the deployed area can be considered to deploy a pad. Moreover, the deployed pads suggested by these schemes may not be able to meet the connected requirements due to sparse environments. In this work, we introduce a new scheme that utilizes the Quad-Tree concept to address the wireless charging pad deployment problem and reduce the number of deployed pads at the same time. Extensive simulations were conducted to illustrate the merits of the proposed schemes by comparing them with different previous schemes on maps of varying sizes. In the case of large maps, the proposed schemes surpassed all previous works, indicating that our approach is more suitable for large-scale network environments.
AI in the Workplace: A Systematic Review of Skill Transformation in the Industry
Authors: Babashahi Leili , Barbosa Carlos Eduardo , Lima Yuri , Lyra Alan , Salazar Herbert , Argôlo Matheus , Almeida Marcos Antonio de , Souza Jano Moreira de
Published: June 2024

Artificial Intelligence (AI) applications streamline workflows, automate tasks, and require adaptive strategies for effective integration into business processes. This research explores the transformative influence of AI on various industries, such as software engineering, automation, education, accounting, mining, legal services, and media. We investigate the relationship between technological advancements and the job market to identify relevant skills for individuals and organizations for implementing and managing AI systems and human–machine interactions necessary for actual and future jobs. We focus on the essential adaptations for individuals and organizations to flourish in this era. To bridge the gap between AI-driven demands and the existing capabilities of the workforce, we employ the Rapid Review methodology to explore the integration of AI in businesses, identify crucial skill sets, analyze challenges, and propose solutions in this dynamic age. We searched the Scopus database, screening a total of 39 articles, of which we selected 20 articles for this systematic review. The inclusion criteria focused on conference papers and journal articles from 2020 or later and written in English. The selected articles offer valuable insights into the impact of AI on education, business, healthcare, robotics, manufacturing, and automation across diverse sectors, as well as providing perspectives on the evolving landscape of expertise. The findings underscore the importance of crucial skill sets, such as technical proficiency and adaptability, to successfully adopt AI. Businesses respond strategically by implementing continuous skill adaptation and ethical technology to address challenges. The paper concludes by emphasizing the imperative of balanced skill development, proactive education, and strategic integration to navigate the profound impact of AI on the workforce effectively.
The Impact of Inlet Structure on Stratification Performance in Thermal Storage Tanks: A Study through Simulation and Experimental Analysis
Authors: Xing Yongjie , Zhang Xiaofen , Zhang Zilong , Liu Fang
Published: June 2024

Thermal storage tanks are the most widely used devices for thermodynamic storage. Their stratification performance is a key factor in determining their effectiveness. In this study, a structure was proposed to improve the thermal stratification of an elbow-type thermal storage tank. An experimental study was conducted on its exothermic properties for applications in hot water storage tanks. An experimental analysis was performed to investigate the exothermic properties of the proposed structure, and the results were compared with those obtained from simulations using CFD (ANSYS 19.1) software. To investigate the effect of thermal stratification on the water inlet structure, the Richardson number, hot water output rate, and MIX number of the elbow inlet structure were compared with those of the water distributor inlet structure. The results show that the MIX numbers corresponding to the inlet structures of the two types of tanks, the elbow and water distributor types, are not very different. These values were almost identical to the Richardson numbers. Under the same working conditions, the hot water output rate was 84.90% for the elbow inlet structure and 76.39% for the water distributor inlet structure. In conclusion, elbow-type water inlet structures are easy to install, and the manufacturing process is simplified.
A Novel Techno-Economical Control of UPFC against Cyber-Physical Attacks Considering Power System Interarea Oscillations
Authors: Mosleh Muntasser Ahmed Mosleh , Umurkan Nurettin
Published: June 2024

In the field of electrical engineering, there is an increasing concern among managers and operators about the secure and cost-efficient operation of smart power systems in response to disturbances caused by physical cyber attacks and natural disasters. This paper introduces an innovative framework for the hybrid, coordinated control of Unified Power Flow Controllers (UPFCs) and Power System Stabilizers (PSSs) within a power system. The primary objective of this framework is to enhance the system’s security metrics, including stability and resilience, while also considering the operational costs associated with defending against cyber-physical attacks. The main novelty of this paper lies in the introduction of a real-time online framework that optimally coordinates a power system stabilizer, power oscillation damper, and unified power flow controller to enhance the power system’s resilience against transient disturbances caused by cyber-physical attacks. The proposed approach considers technical performance indicators of power systems, such as voltage fluctuations and losses, in addition to economic objectives, when determining the optimal dynamic coordination of UPFCs and PSSs—aspects that have been neglected in previous modern research. To address the optimization problem, a novel multi-objective search algorithm inspired by Harris hawks, known as the Multi-Objective Harris Hawks (MOHH) algorithm, was developed. This algorithm is crucial in identifying the optimal controller coefficient settings. The proposed methodology was tested using standard IEEE9-bus and IEEE39-bus test systems. Simulation results demonstrate the effectiveness and efficiency of this approach in achieving optimal system recovery, both technically and economically, in the face of cyber-physical attacks.
Numerical Analysis of the Effects of Different Window-Opening Strategies on the Indoor Pollutant Dispersion in Street-Facing Buildings
Authors: Wu Yongjia , Ouyang Yilian , Shi Tianhao , Li Zhiyong , Ming Tingzhen
Published: June 2024

The idling of automobiles at street intersections can lead to pollutant accumulation which impacts the health of residents in street-facing buildings. Previous research focused on pollutant dispersion within street canyons and did not consider the coupling of indoor and outdoor pollutants. This paper employs the computational fluid dynamics (CFD) method to simulate the dispersion characteristics of vehicle emission pollutants in street canyons, primarily investigating the indoor and outdoor pollutant dispersion patterns under various window opening configurations (single-sided ventilation, corner ventilation, and different positions of the glass under corner ventilation). Additionally, the study considers the impacts of the aspect ratio and ambient wind speed. Studies have shown that corner ventilation is effective in reducing indoor pollutant levels. When the two window glass positions are far away from the center of the intersection, the average CO mass fraction in the single-sided ventilation room is reduced by 87.1%. The average indoor CO mass fraction on the leeward side decreases with the increasing wind speed and aspect ratio. At a wind speed of 8 m/s, the average indoor CO mass fraction on the leeward side decreases to 2.45 × 10−8. At an aspect ratio of 2, the indoor CO mass fraction on the leeward side decreases with increasing floors before stabilizing at approximately 4.77 × 10−9. This study suggests optimal window opening strategies to reduce indoor pollutant levels in street-facing buildings at street intersections, offering guidance to indoor residents on window ventilation practices.
Effects of Electrolyte Solvent Composition on Solid Electrolyte Interphase Properties in Lithium Metal Batteries: Focusing on Ethylene Carbonate to Ethyl Methyl Carbonate Ratios
Authors: Nogales Paul Maldonado , Lee Sangyup , Yang Seunga , Jeong Soon-Ki
Published: June 2024

This study investigated the influence of variations in the mixing ratio of ethylene carbonate (EC) to ethyl methyl carbonate (EMC) on the composition and effectiveness of the solid electrolyte interphase (SEI) in lithium-metal batteries. The SEI is crucial for battery performance, as it prevents continuous electrolyte decomposition and inhibits the growth of lithium dendrites, which can cause internal short circuits leading to battery failure. Although the properties of the SEI largely depend on the electrolyte solvent, the influence of the EC:EMC ratio on SEI properties has not yet been elucidated. Through electrochemical testing, ionic conductivity measurements, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy, the formation of Li2CO3, LiF, and organolithium compounds on lithium surfaces was systematically analyzed. This study demonstrated that the EC:EMC ratio significantly affected the SEI structure, primarily owing to the promotion of the formation of a denser SEI layer. Specifically, the ratios of 1:1 and 1:3 facilitated a uniform distribution and prevalence of Li2CO3 and LiF throughout the SEI, thereby affecting cell performance. Thus, precise control of the EC:EMC ratio is essential for enhancing the mechanical robustness and electrochemical stability of the SEI, thereby providing valuable insights into the factors that either enhance or impede effective SEI formation.
Bladder Reconstruction in Cats Using In-Body Tissue Architecture (iBTA)-Induced Biosheet
Authors: Fujita Naoki , Sugiyama Fumi , Tsuboi Masaya , Nakamura Hazel Kay , Nishimura Ryohei , Nakayama Yasuhide , Fujita Atsushi
Published: June 2024

Urinary tract diseases are common in cats, and often require surgical reconstruction. Here, to explore the possibility of urinary tract reconstruction in cats using in-body tissue architecture (iBTA), biosheets fabricated using iBTA technology were implanted into the feline bladder and the regeneration process was histologically evaluated. The biosheets were prepared by embedding molds into the dorsal subcutaneous pouches of six cats for 2 months. A section of the bladder wall was removed, and the biosheets were sutured to the excision site. After 1 and 3 months of implantation, the biosheets were harvested and evaluated histologically. Implantable biosheets were formed with a success rate of 67%. There were no major complications following implantation, including tissue rejection, severe inflammation, or infection. Urinary incontinence was also not observed. Histological evaluation revealed the bladder lumen was almost entirely covered by urothelium after 1 month, with myofibroblast infiltration into the biosheets. After 3 months, the urothelium became multilayered, and mature myocytes and nerve fibers were observed at the implantation site. In conclusion, this study showed that tissue reconstruction using iBTA can be applied to cats, and that biosheets have the potential to be useful in both the structural and functional regeneration of the feline urinary tract.
Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations
Authors: Santiago-Lamelas Lucía , Castro-Santos Patricia , Carracedo Ángel , Olloquequi Jordi , Díaz-Peña Roberto
Published: June 2024

Human leukocyte antigen (HLA) molecules and their relationships with natural killer (NK) cells, specifically through their interaction with killer-cell immunoglobulin-like receptors (KIRs), exhibit robust associations with the outcomes of diverse diseases. Moreover, genetic variations in HLA and KIR immune system genes offer limitless depths of complexity. In recent years, a surge of high-powered genome-wide association studies (GWASs) utilizing single nucleotide polymorphism (SNP) arrays has occurred, significantly advancing our understanding of disease pathogenesis. Additionally, advances in HLA reference panels have enabled higher resolution and more reliable imputation, allowing for finer-grained evaluation of the association between sequence variations and disease risk. However, it is essential to note that the majority of these GWASs have focused primarily on populations of Caucasian and Asian origins, neglecting underrepresented populations in Latin America and Africa. This omission not only leads to disparities in health care access but also restricts our knowledge of novel genetic variants involved in disease pathogenesis within these overlooked populations. Since the KIR and HLA haplotypes prevalent in each population are clearly modelled by the specific environment, the aim of this review is to encourage studies investigating HLA/KIR involvement in infection and autoimmune diseases, reproduction, and transplantation in underrepresented populations.
The Importance of Sleep in Overcoming Childhood Obesity and Reshaping Epigenetics
Authors: Richter Erika , Patel Priyadarshni , Babu Jeganathan Ramesh , Wang Xu , Geetha Thangiah
Published: June 2024

The development of childhood obesity is a complex process influenced by a combination of genetic predisposition and environmental factors, such as sleep, diet, physical activity, and socioeconomic status. Long-term solutions for decreasing the risk of childhood obesity remain elusive, despite significant advancements in promoting health and well-being in school and at home. Challenges persist in areas such as adherence to interventions, addressing underlying social determinants, and individual differences in response to treatment. Over the last decade, there has been significant progress in epigenetics, along with increased curiosity in gaining insights into how sleep and lifestyle decisions impact an individual’s health. Epigenetic modifications affect the expression of genes without causing changes to the fundamental DNA sequence. In recent years, numerous research studies have explored the correlation between sleep and the epigenome, giving a better understanding of DNA methylation, histone modification, and non-coding RNAs. Although significant findings have been made about the influence of sleep on epigenetics, a notable gap exists in the literature concerning sleep-related genes specifically associated with childhood obesity. Consequently, it is crucial to delve deeper into this area to enhance our understanding. Therefore, this review primarily focuses on the connection between sleep patterns and epigenetic modifications in genes related to childhood obesity. Exploring the interplay between sleep, epigenetics, and childhood obesity can potentially contribute to improved overall health outcomes. This comprehensive review encompasses studies focusing on sleep-related genes linked to obesity.
External Support of Autologous Internal Jugular Vein Grafts with FRAME Mesh in a Porcine Carotid Artery Model
Authors: Chlupac Jaroslav , Frank Jan , Sedmera David , Fabian Ondrej , Simunkova Zuzana , Mrazova Iveta , Novak Tomas , Vanourková Zdenka , Benada Oldrich , Pulda Zdenek , Adla Theodor , Kveton Martin , Lodererova Alena , Voska Ludek , Pirk Jan , Fronek Jiri
Published: June 2024

Background: Autologous vein grafts are widely used for bypass procedures in cardiovascular surgery. However, these grafts are susceptible to failure due to vein graft disease. Our study aimed to evaluate the impact of the latest-generation FRAME external support on vein graft remodeling in a preclinical model. Methods: We performed autologous internal jugular vein interposition grafting in porcine carotid arteries for one month. Four grafts were supported with a FRAME mesh, while seven unsupported grafts served as controls. The conduits were examined through flowmetry, angiography, macroscopy, and microscopy. Results: The one-month patency rate of FRAME-supported grafts was 100% (4/4), whereas that of unsupported controls was 43% (3/7, Log-rank p = 0.071). On explant angiography, FRAME grafts exhibited significantly more areas with no or mild stenosis (9/12) compared to control grafts (3/21, p = 0.0009). Blood flow at explantation was higher in the FRAME grafts (145 ± 51 mL/min) than in the controls (46 ± 85 mL/min, p = 0.066). Area and thickness of neo-intimal hyperplasia (NIH) at proximal anastomoses were similar for the FRAME and the control groups: 5.79 ± 1.38 versus 6.94 ± 1.10 mm2, respectively (p = 0.558) and 480 ± 95 vs. 587 ± 52 μm2/μm, respectively (p = 0.401). However, in the midgraft portions, the NIH area and thickness were significantly lower in the FRAME group than in the control group: 3.73 ± 0.64 vs. 6.27 ± 0.64 mm2, respectively (p = 0.022) and 258 ± 49 vs. 518 ± 36 μm2/μm, respectively (p = 0.0002). Conclusions: In our porcine model, the external mesh FRAME improved the patency of vein-to-carotid artery grafts and protected them from stenosis, particularly in the mid regions. The midgraft neo-intimal hyperplasia was two-fold thinner in the meshed grafts than in the controls.
The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights
Authors: Bender Martin , Abicht Jan-Michael , Reichart Bruno , Leuschen Maria , Wall Felicia , Radan Julia , Neumann Elisabeth , Mokelke Maren , Buttgereit Ines , Michel Sebastian , Ellgass Reinhard , Gieseke Katja , Steen Stig , Paskevicius Audrius , Denner Joachim , Godehardt Antonia W. , Tönjes Ralf R. , Hagl Christian , Ayares David , Wolf Eckhard , Schmoeckel Michael , Brenner Paolo , Müller Martin B. , Längin Matthias
Published: June 2024

Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are necessary. In allotransplantation, endothelial cells and their sugar-rich surface—the endothelial glycocalyx—are known to influence organ rejection. In xenotransplantation, however, only in vitro data exist on the role of the endothelial glycocalyx so far. Thus, in the current study, we analyzed the changes of the endothelial glycocalyx components hyaluronan, heparan sulfate and syndecan-1 after pig-to-baboon cardiac xenotransplantations in the perioperative (n = 4) and postoperative (n = 5) periods. These analyses provide first insights into changes of the endothelial glycocalyx after pig-to-baboon cardiac xenotransplantation and show that damage to the endothelial glycocalyx seems to be comparable or even less pronounced than in similar human settings when current strategies of cardiac xenotransplantation are applied. At the same time, data from the experiments where current strategies, like non-ischemic preservation, growth inhibition or porcine cytomegalovirus (a porcine roseolovirus (PCMV/PRV)) elimination could not be applied indicate that damage of the endothelial glycocalyx also plays an important role in cardiac xenotransplantation.
Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications
Authors: Sato Hiromichi , Meng Sikun , Hara Tomoaki , Tsuji Yoshiko , Arao Yasuko , Sasaki Kazuki , Kobayashi Shogo , di Luccio Eric , Hirotsu Takaaki , Satoh Taroh , Doki Yuichiro , Eguchi Hidetoshi , Ishii Hideshi
Published: June 2024

Gastrointestinal cancers, which include a variety of esophageal and colorectal malignancies, present a global health challenge and require effective treatment strategies. In the evolving field of cancer immunotherapy, tissue-resident memory T cells (Trm cells) have emerged as important players in the immune response within nonlymphoid tissues. In this review, we summarize the characteristics and functions of Trm cells and discuss their profound implications for patient outcomes in gastrointestinal cancers. Positioned strategically in peripheral tissues, Trm cells have functions beyond immune surveillance, affecting tumor progression, prognosis, and response to immunotherapy. Studies indicate that Trm cells are prognostic markers and correlate positively with enhanced survival. Their presence in the tumor microenvironment has sparked interest in their therapeutic potential, particularly with respect to immune checkpoint inhibitors, which may improve cancer treatment. Understanding how Trm cells work will not only help to prevent cancer spread through effective treatment but will also contribute to disease prevention at early stages as well as vaccine development. The role of Trm cells goes beyond just cancer, and they have potential applications in infectious and autoimmune diseases. This review provides a thorough analysis of Trm cells in gastrointestinal cancers, which may lead to personalized and effective cancer therapies.
A Novel Multi-Scaled Deep Convolutional Structure for Punctilious Human Gait Authentication
Authors: Yousef Reem N. , Ata Mohamed Maher , Rashed Amr E. Eldin , Badawy Mahmoud , Elhosseini Mostafa A. , Bahgat Waleed M.
Published: June 2024

The need for non-interactive human recognition systems to ensure safe isolation between users and biometric equipment has been exposed by the COVID-19 pandemic. This study introduces a novel Multi-Scaled Deep Convolutional Structure for Punctilious Human Gait Authentication (MSDCS-PHGA). The proposed MSDCS-PHGA involves segmenting, preprocessing, and resizing silhouette images into three scales. Gait features are extracted from these multi-scale images using custom convolutional layers and fused to form an integrated feature set. This multi-scaled deep convolutional approach demonstrates its efficacy in gait recognition by significantly enhancing accuracy. The proposed convolutional neural network (CNN) architecture is assessed using three benchmark datasets: CASIA, OU-ISIR, and OU-MVLP. Moreover, the proposed model is evaluated against other pre-trained models using key performance metrics such as precision, accuracy, sensitivity, specificity, and training time. The results indicate that the proposed deep CNN model outperforms existing models focused on human gait. Notably, it achieves an accuracy of approximately 99.9% for both the CASIA and OU-ISIR datasets and 99.8% for the OU-MVLP dataset while maintaining a minimal training time of around 3 min.
Relationships between Grey Matter Volume in the Bilateral Superior Frontal Gyrus and Reactive Aggression Varied by Level of Traditional Masculinity
Authors: Liu Weijun , Ding Cody , Li Ziang , Chen Hong
Published: June 2024

Although previous behavioral studies have associated reactive aggression (RA) and proactive aggression (PA) with traditional masculinity, further investigation is needed into the traditional masculinity-linked neuroanatomical characteristics of RA and PA. This study analyzed the traditional masculinity-by-aggression interaction in 705 participants (350 men) by measuring grey matter volume (GMV). We have expanded on previous studies and found that traditional masculinity was not associated with RA and PA when not controlled for traditional femininity. However, the association appeared when controlling for it. Furthermore, we found significant traditional masculinity-by-RA interactions on the GMV in the bilateral superior frontal gyrus, a region known to be involved in cognitive control. When traditional masculinity scores were 1 standard deviation above the mean, there was a positive correlation between RA and the GMV in the bilateral superior frontal gyrus. Conversely, when traditional masculinity scores were 1 standard deviation below the mean, there was a negative correlation between RA and the GMV in the region. However, no traditional masculinity-linked neuroanatomical characteristics of PA were found. The results indicated that individuals with high/low traditional masculinity perceived RA as a different outcome (gain or loss) of self-control. The results supported an opportunity to develop prevention or intervention strategies for RA.
Neural Mechanisms of Inhibition in Scientific Reasoning: Insights from fNIRS
Authors: Liu Donglin , Jamshaid Samrah , Wang Lijuan
Published: June 2024

This study examines the impact of response and semantic inhibition on scientific reasoning using fNIRS data from 30 students (15 male, 15 female). Utilizing Go/Nogo and Stroop-like tasks within a modified speeded-reasoning task, it was found that inhibition significantly influences scientific reasoning. Specifically, slower responses and lower accuracy on incongruent statements were linked to increased activity in bilateral dorsolateral prefrontal cortex (DLPFC) and pre-supplementary motor area (pre-SMA). The research shows that both DLPFC and pre-SMA are associated with overcoming misconceptions in scientific reasoning. The findings suggest that understanding inhibitory mechanisms can enhance educational strategies to improve critical thinking and scientific literacy.
Fault Diagnosis of Centrifugal Chiller Based on Extreme Gradient Boosting
Authors: Liu Yaxiang , Liang Tao , Zhang Mengxin , Jing Nijie , Xia Yudong , Ding Qiang
Published: June 2024

Centrifugal chillers have been widely used in medium- and large-scale air conditioning projects. However, equipment running with faults will result in additional energy consumption. Meanwhile, it is difficult to diagnose the minor faults of the equipment. Therefore, the Extreme Gradient Boost (XGBoost) algorithm was used to solve the above problem in this article. The ASHRAE RP-1043 dataset was employed for research, utilizing the feature splitting principle of XGBoost to reduce the data dimension to 23 dimensions. Subsequently, the five important parameters of the XGBoost algorithm were optimized using Multi-swarm Cooperative Particle Swarm Optimization (MSPSO). The minor fault diagnosis model, MSPSO-XGBoost, was established. The results show that the ability of the proposed MSPSO-XGBoost model to diagnose eight different states is uniform, and the diagnostic accuracy of the model reaches 99.67%. The accuracy rate is significantly improved compared to that of the support vector machine (SVM) and back propagation neural network (BPNN) diagnostic models.
Does 5-ALA Fluorescence Microscopy Improve Complete Resectability in Cerebral/Cerebellar Metastatic Surgery? A Retrospective Data Analysis from a Cranial Center
Authors: Sarkis Hraq Mourad , Zawy Alsofy Samer , Stroop Ralf , Lewitz Marc , Schipmann Stephanie , Unnewehr Markus , Paulus Werner , Nakamura Makoto , Ewelt Christian
Published: June 2024

(1) Background: In this study, the intraoperative fluorescence behavior of brain metastases after the administration of 5-aminolevulinic acid (5-ALA) was analyzed. The aim was to investigate whether the resection of brain metastases using 5-ALA fluorescence also leads to a more complete resections and thus to a prolongation of survival; (2) Methods: The following variables have been considered: age, sex, number of metastases, localization, involvement of eloquent area, correlation between fluorescence and primary tumor/subtype, resection, and survival time. The influence on the degree of resection was determined with a control MRI within the first three postoperative days; (3) Results: Brain metastases fluoresced in 57.5% of cases. The highest fluorescence rates of 73.3% were found in breast carcinoma metastases and the histologic subtype adenocarcinoma (68.1%). No correlation between fluorescence behavior and localization, primary tumor, or histological subtype was found. Complete resection was detected in 82.5%, of which 56.1% were fluorescence positive. There was a trend towards improved resectability (increase of 12.1%) and a significantly longer survival time (p = 0.009) in the fluorescence-positive group; (4) Conclusions: 5-ALA-assisted extirpation leads to a more complete resection and longer survival and can therefore represent a low-risk addition to modern surgery for brain metastases.
Photoluminescence Sensing of Lead Halide Perovskite Nanocrystals and Their Two-Dimensional Structural Materials
Authors: Huang Yaning , Zhang Chen , Liu Xuelian , Chen Xi
Published: June 2024

In recent years, the development of new efficient, fast, and intuitive materials and methods for photoluminescence (PL) sensing has become a research hotspot in analytical chemistry. Lead halide perovskite (LHP) materials have the characteristics of adjustable PL properties, high PL efficiency, and a variety of synthesis methods. Their PL is also sensitive to the change in specific factors in the environment. Based on these characteristics, LHP has shown good application prospects in the field of optical sensing. The study of the structural dimension, organic composition, or doped ions of LHP is helpful in exploring its sensing potential and proposing new sensing mechanisms, which have important research significance to promote sensing applications. In this review, the PL characteristics and sensing mechanisms, as well as their sensing applications of two- and three dimensional LHP, are discussed and summarized.
Skin Reactions in Children with Type 1 Diabetes Associated with the Use of New Diabetes Technologies—An Observational Study from a Regional Polish Pediatric Diabetes Center
Authors: Ledwoń Ewa , Zemła-Szten Paula , von dem Berge Thekla , Nalewajko Krzysztof , Passanisi Stefano , Piona Claudia , dos Santos Tiago , Svensson Jannet , Korsgaard Berg Anna , Chobot Agata
Published: June 2024

The study aimed to estimate the prevalence of skin problems in children and adolescents with type 1 diabetes (T1D) using insulin pumps (IPs) and/or continuous glucose monitoring (CGM) in our center and analyze their association with various factors. As part of the international ISPAD JENIOUS-initiated SKIN-PEDIC project, we interviewed and examined patients who visited the regional pediatric diabetes center in Opole (Poland) for four weeks regarding the use of IP and/or CGM and the presence of skin problems. Body mass index (BMI) and glycemic parameters were obtained retrospectively from medical records. Among 115 individuals (45.2% girls, 83.5% IP users, 96.5% CGM users), old scars were the most common skin problem (IP users 53.1%; CGM users 66.4%), while ≥2 types of skin problems co-occurred (IP users 40.6%; CGM users 27.3%). Longer IP use was associated with a higher prevalence of skin problems (50% for IP < 1 year, 98.1%-IP 1–3 years, 100% for IP > 3 years; p < 0.001), pointing out extra attention with IP use > 1 year. No significant associations were found between skin problems and gender, age, BMI centile and glycemic parameters. Dermatological complications were common among children using IP and CGM in our center, highlighting the need for vigilant monitoring and early intervention to manage these skin-related issues effectively.
Investigation of the Bonding Mechanism of Al Powder Particles through Pulse Current Sintering Technology
Authors: Lv Zhou , Liu Ruifeng
Published: June 2024

Compared with traditional powder metallurgy, pulse current sintering is an advanced powder-forming technology, but its bonding mechanism is still an open topic for debate. In this paper, pulse current sintering is used as the connection technology and millimeter-sized Al particles are used as the research object. In the whole sintering process, no pressure was loaded; the function of the pulse current was the only source of heat with which to achieve the bonding of Al particles. The bonding mechanism of pulse current sintering was investigated from the perspective of material connection behavior. The results show that the pulse current density of the particle surface reaches 3.48 × 105 A/m2 instantly, while the current density of the particle center is only 8187 A/m2 at the initial stage, which is the main difference between pulse current sintering and traditional powder metallurgy sintering. With the densification process, the current density and temperature distribution in the contact region as well as the center of Al particles contact region tend to be more consistent. Finally, dense interfacial bonding was obtained, and the contact region of Al particles also demonstrated a high hardness value of 0.6385 GPa and yield strength value of 212.83 MPa. The whole process can be considered as a comprehensive action of melting (evaporation), diffusion, and plastic deformation. Based on the above results, a new technology, named high-frequency pulse current sintering, was proposed.
Residential Sizing of Solar Photovoltaic Systems and Heat Pumps for Net Zero Sustainable Thermal Building Energy
Authors: Rana Shafquat , Jamil Uzair , Asgari Nima , Hayibo Koami S. , Groza Julia , Pearce Joshua M.
Published: June 2024

To enable net zero sustainable thermal building energy, this study develops an open-source thermal house model to couple solar photovoltaic (PV) and heat pumps (HPs) for grid-connected residential housing. The calculation of both space heating and cooling thermal loads and the selection of HP is accomplished with a validated Python model for air-source heat pumps. The capacity of PV required to supply the HPs is calculated using a System Advisor Model integrated Python model. Self-sufficiency and self-consumption of PV and the energy imported/exported to the grid for a case study are provided, which shows that simulations based on the monthly load profile have a significant reduction of 43% for energy sent to/from the grid compared to the detailed hourly simulation and an increase from 30% to 60% for self-consumption and self-sufficiency. These results show the importance of more granular modeling and also indicate mismatches of PV generation and HP load based on hourly simulation datasets. The back-calculation PV sizing algorithm combined with HP and thermal loads presented in this study exhibited robust performance. The results indicate this approach can be used to accelerate the solar electrification of heating and cooling to offset the use of fossil fuels in northern climates.
A Split-Face Comparison of Novel Microneedle Patch versus Botulinum Toxin-A and Microneedle Patch for Improvement in Undereye Skin Texture
Authors: Te Polen , Meephansan Jitlada , Sirithanabadeekul Punyaphat , Pureesrisak Purit , Tantisantisom Kittipong , Thongma Sattra , Rayanasukha Yossawat , Adulyaritthikul Punyanuch , Khanchaitit Paisan
Published: June 2024

(1) Background: The emergence of microneedle patch technology and its development as a transdermal drug delivery platform have shown proven results in improving skin texture and appearance. This study was conducted to determine the efficacy of the microneedle patch (MNP)-only cosmesis of undereye skin texture and wrinkles against patch cosmesis with diluted botulinum toxin-A. (2) Methods: A total of 23 Thai females volunteered for this prospective clinical trial. Each participant was treated according to a split-face design, with the application of diluted botulinum toxin-A through MNP technology to the right undereye and a normal saline MNP application to the left undereye. Test areas were recorded at baseline and 2, 4, 8, 12, and 16 weeks after the initial treatment. (3) Results: Botulinum toxin-A was successfully delivered to the skin by MNP technology. After the initial treatment, these novel transdermal drug delivery patches significantly improved infraorbital hollowness at week 8 and wrinkles at week 16. In addition, the skin surface was markedly enhanced, with no adverse effects observed during the trial. (4) Conclusions: Novel MNPs are an effective and safe technology for use in the management of undereye skin aging. Combination treatment with botulinum toxin-A-impregnated devices gave a higher patient satisfaction than MNPs alone.
Synthesis, Structure and Magnetic Properties of Low-Dimensional Copper(II) trans-1,4-cyclohexanedicarboxylate
Authors: Demakov Pavel A. , Ovchinnikova Anna A. , Dorovatovskii Pavel V. , Lazarenko Vladimir A. , Lavrov Alexander N. , Dybtsev Danil N. , Fedin Vladimir P.
Published: June 2024

A reaction between copper(II) nitrate and trans-1,4-cyclohexanedicarboxylic acid (H2chdc) carried out under hydrothermal conditions led to a new metal-organic coordination polymer [Cu2(Hchdc)2(chdc)]n. According to single-crystal XRD data, the compound is based on bi-nuclear paddlewheel-type carboxylate blocks that are joined with polymeric chains due to the (μ3-κ1:κ2) coordination of carboxylate groups. The chains are interconnected by chdc2− bridging ligands into layers containing free COOH groups of terminal Hchdc−. The neighboring layers adopt a RCOOH···OOCR hydrogen bond-assisted arrangement into a dense-packed structure. Magnetization measurements showed the presence of a strong antiferromagnetic exchange interaction (J/kB = −495 K) inside the bi-nuclear blocks. At the same time, no significant interaction was found between the {-Cu2(OOCR)4-} units in spite of their polymeric in-chain packing. Patterns of magnetic behavior of [Cu2(Hchdc)2(chdc)]n were thoroughly analyzed and explained from a structural point of view.
Chloride-Induced Stress Corrosion Cracking of Friction Stir-Welded 304L Stainless Steel: Effect of Microstructure and Temperature
Authors: Naskar Anirban , Bhattacharyya Madhumanti , Jana Saumyadeep , Darsell Jens , Raja Krishnan S. , Charit Indrajit
Published: June 2024

Dry storage canisters of used nuclear fuels are fabricated using SUS 304L stainless steel. Chloride-induced stress corrosion cracking (CISCC) is one of the major failure modes of dry storage canisters. The cracked canisters can be repaired by friction stir welding (FSW), a low-heat input ‘solid-phase’ welding process. It is important to evaluate the ClSCC resistance of the friction stir welded material. Stress corrosion cracking (SCC) studies were carried out on mill-annealed base materials and friction stir welded 304L stainless U-bend specimens in 3.5% NaCl + 5 N H2SO4 solution at room temperature and boiling MgCl2 solution at 155 °C. The engineering stress on the outer fiber of the FSW U-bend specimen was ~60% higher than that of the base metal (BM). In spite of the higher stress level of the FSW, both materials (FSW and BM) showed almost similar SCC failure times in the two different test solutions. The SCC occurred in the thermo-mechanically affected zone (TMAZ) of the FSW specimens in the 3.5% NaCl + 5 N H2SO4 solution at room temperature, while the stirred zone (SZ) was relatively crack-free. The failure occurred at the stirred zone when tested in the boiling MgCl2 solution. Hydrogen reduction was the cathodic reaction in the boiling MgCl2 solution, which promoted hydrogen-assisted cracking of the heavily deformed stirred zone. The emergence of the slip step followed by passive film rupture and dissolution of the slip step could be the SCC events in the 3.5% NaCl + 5 N H2SO4 solution at room temperature. However, the slip step height was not sufficient to cause passivity breakdown in the fine-grained SZ. Therefore, the SCC occurred in the partially recrystallized softer TMAZ. Overall, the friction-stirred 304L showed higher tolerance to ClSCC than the 304L base metal.
X-ray Single-Crystal Analysis, Pharmaco-Toxicological Profile and Enoyl-ACP Reductase-Inhibiting Activity of Leading Sulfonyl Hydrazone Derivatives
Authors: Teneva Yoanna , Simeonova Rumyana , Besarboliev Orlin , Sbirkova-Dimitrova Hristina , Angelova Violina T.
Published: June 2024

Taking into consideration the growing resistance towards currently available antimycobacterials, there is still an unmet need for the development of new chemotherapeutic agents to combat the infectious agents. This study presents X-ray single-crystal analysis to verify the structure of leading sulfonyl hydrazone 3b, which has proven its potent antimycobacterial activity against Mycobacterium tuberculosis H37Rv with an MIC value of 0.0716 μM, respectively, low cytotoxicity, and very high selectivity indexes (SI = 2216), and which has been fully characterized by Nuclear Magnetic Resonance (NMR) and High-Resolution Mass Spectrometry (HRMS) methods. Furthermore, this study assessed the ex vivo antioxidant activity, acute and subacute toxicity, and in vitro inhibition capacity against enoyl-ACP reductase of hydrazones 3a and 3b, as 3a was identified as the second leading compound in our previous research. Compared to isoniazid, compounds 3a and 3b demonstrated lower acute toxicity for intraperitoneal administration, with LD50 values of 866 and 1224.7 mg/kg, respectively. Subacute toxicity tests, involving the repeated administration of a single dose of the test samples per day, revealed no significant deviations in hematological and biochemical parameters or pathomorphological tissues. The compounds exhibited potent antioxidant capabilities, reducing malondialdehyde (MDA) levels and increasing reduced glutathione (GSH). Enzyme inhibition assays of the sulfonyl hydrazones 3a and 3b with IC50 values of 18.2 µM and 10.7 µM, respectively, revealed that enoyl acyl carrier protein reductase (InhA) could be considered as their target enzyme to exhibit their antitubercular activities. In conclusion, the investigated sulfonyl hydrazones display promising drug-like properties and warrant further investigation.
Drivers for the Diversity of Mollusc Communities in Unique Calcareous Fen Habitats
Authors: Lewin Iga , Tarkowski Adam , Sugier Piotr , Płaska Wojciech , Buczyńska Edyta , Buczyński Paweł
Published: June 2024

The research was carried out in calcareous fen habitats which share coverage with Natura 2000 sites designated under the EU Habitats and the Birds Directive. A total of 27 taxa of molluscs were recorded: 23 gastropod and 4 bivalve species. Anisus vorticulus, one of the species of Community interest whose conservation requires designation of special conservation areas within the Habitats Directive Natura 2000, was subrecedent and accedent in mollusc communities. Calcareous fen habitats offer the aquatic organisms harsh environmental conditions including a relatively high temperature of the water up to 33.29 °C (undrained fens), oxygen deficits in the water, high pH of up to 11.08 (fen pools) and conductivity above 3000 μS cm−1 (fen ditches). Therefore molluscs have to face extreme environmental conditions. Temperature of the water, pH, dissolved oxygen and conductivity were the parameters most associated with the distribution of mollusc species in the calcareous fen habitats. The abundance of submerged and floating macrophytes, the degree of habitat persistence and the fish predation pressure on molluscs also exerted a significant effect on their distribution. The calcareous fen habitats that are listed in Annex I of the European Union Habitats Directive create a unique valuable ecosystem that contributes to the natural diversity of aquatic organisms.
Unambiguous Models and Machine Learning Strategies for Anomalous Extreme Events in Turbulent Dynamical System
Authors: Qi Di
Published: June 2024

Data-driven modeling methods are studied for turbulent dynamical systems with extreme events under an unambiguous model framework. New neural network architectures are proposed to effectively learn the key dynamical mechanisms including the multiscale coupling and strong instability, and gain robust skill for long-time prediction resistive to the accumulated model errors from the data-driven approximation. The machine learning model overcomes the inherent limitations in traditional long short-time memory networks by exploiting a conditional Gaussian structure informed of the essential physical dynamics. The model performance is demonstrated under a prototype model from idealized geophysical flow and passive tracers, which exhibits analytical solutions with representative statistical features. Many attractive properties are found in the trained model in recovering the hidden dynamics using a limited dataset and sparse observation time, showing uniformly high skill with persistent numerical stability in predicting both the trajectory and statistical solutions among different statistical regimes away from the training regime. The model framework is promising to be applied to a wider class of turbulent systems with complex structures.
Numerical Research on Leakage Characteristics of Pure Hydrogen/Hydrogen-Blended Natural Gas in Medium- and Low-Pressure Buried Pipelines
Authors: Li Jiadong , Xie Bingchuan , Gong Liang
Published: June 2024

To investigate the leakage characteristics of pure hydrogen and hydrogen-blended natural gas in medium- and low-pressure buried pipelines, this study establishes a three-dimensional leakage model based on Computational Fluid Dynamics (CFD). The leakage characteristics in terms of pressure, velocity, and concentration distribution are obtained, and the effects of operational parameters, ground hardening degree, and leakage parameters on hydrogen diffusion characteristics are analyzed. The results show that the first dangerous time (FDT) for hydrogen leakage is substantially shorter than for natural gas, emphasizing the need for timely leak detection and response. Increasing the hydrogen blending ratio accelerates the diffusion process and decreases the FDT, posing greater risks for pipeline safety. The influence of soil hardening on gas diffusion is also examined, revealing that harder soils can restrict gas dispersion, thereby increasing localized concentrations. Additionally, the relationship between gas leakage time and distance is determined, aiding in the optimal placement of gas sensors and prediction of leakage timing. To ensure the safe operation of hydrogen-blended natural gas pipelines, practical recommendations include optimizing pipeline operating conditions, improving leak detection systems, increasing pipeline burial depth, and selecting materials with higher resistance to hydrogen embrittlement. These measures can mitigate risks associated with hydrogen leakage and enhance the overall safety of the pipeline infrastructure.