Prognosis Evaluation of the Progression of Diffuse Large B-Cell Lymphoma within 24 Months
Authors:   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, H Hong , T Lin ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, M Wan ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, X Li ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, H Huang ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, X Fang ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, Y Chen ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, W Zhang ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, Y Tian ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, Y Yao ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, F Pan ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, H Weng ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, Z Chen ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, L Yu ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China, Y Shen ,   Department of Medical Oncology, Sichuan Cancer Hospital & Institute, School of Medicine University of Electronic Science & Technology of China, China, X Li ,   Department of Medical Oncology, School of Medicine University of Electronic Science & Technology of China, China
Published: January 2023

Purpose: The progression of disease within 24 months (POD24) has been considered to be a strong prognostic indicator for various types of malignant lymphoma. However, the value of POD24 in Diffuse Large B-Cell Lymphoma (DLBCL) is unclear. We evaluated the value of POD24 in patients with DLBCL. Methods: A total of 476 newly diagnosed DLBCL patients were analyzed in this study. Overall Survival (OS) was evaluated by Kaplan Meier method. We performed univariate and multivariate analyses to evaluate the potential prognostic value of POD24. Results: A total of 476 newly diagnosed patients with DLBCL were analyzed in our study. The 5-year OS rates of patients in the POD24 group and non-POD24 group were 22.6% and 82.5%, respectively (HR 7.397; 95% CI 5.403-10.125; p < 0.001). The 5-year OS rates of patients in the POD24 group and non-POD24 group in Complete Release (CR) were 26.5% and 73.7%, respectively (HR 4.374; 95% CI 2.521-7.590; p<0.001). These results were similar in patients with non-CR: the 5-year OS rates were 20.5% and 83.7% (HR 8.697; 95% CI 5.934-12.746; p<0.001). The 5-year OS rates of the POD24 group and the non-POD24 group in the low stage (stage I and II) were 48% and 85.6%, respectively (HR 5.122; 95% CI 2.803-9.363; p<0.001). The results were the same in the high stage (stage III and IV): 10.2% and 79.4% (HR 5.122; 95% CI 2.803-9.363; p<0.001). Only stage was an independent prognostic factor for OS in the POD24 group in the multivariate analysis (P=0.001). Conclusion: The association between POD24 and OS was confirmed, and POD24 can predict poor OS in patients with DLBCL. These marked differences in outcome suggest that POD24 is useful for patient counseling, study design, and risk stratification in DLBCL.