bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Early Acupuncture on Bell’s Palsy Recurrence: Real-World Evidence from Korea
Authors: Choi Yujin , Lee Suji , Yang Changsop , Ahn Eunkyoung
Published: December 2023

Evidence-based treatment for Bell’s palsy includes the administration of steroids within 3 days of symptom onset. Additionally, a few studies have suggested the importance of combining early acupuncture treatment in the acute phase of Bell’s palsy with steroids. This study aimed to observe the impact of early acupuncture for Bell’s palsy using real-world health insurance data in Korea. This retrospective study extracted data from 45,986 adult patients with Bell’s palsy who received steroids between 2015 and 2017 with a follow-up period of at least 3 years until 2020 from the Korea National Health Insurance database. They were divided into the early acupuncture group (n = 28,267) and the comparison group (n = 17,719) based on the presence of an acupuncture treatment code within 7 days of diagnosis. The impact of early acupuncture on the likelihood of Bell’s palsy recurrence was evaluated using multivariate logistic regression. The patients in the early acupuncture group had a lower likelihood of recurrence (odds ratio: 0.81, 95% confidence interval: 0.69–0.95). This study observed a beneficial impact of early acupuncture on Bell’s palsy using real-world health insurance data in Korea. Further research is required to confirm these findings.
Industrial Heritage in Malaga (Spain): Research and Education via Four Key Design Concepts
Authors: Cimadomo Guido , Varagnoli Claudio
Published: December 2023

The industrial heritage in Spain, despite important advancements in the past decades, remains under-recognized, vulnerable, and inadequately appreciated. Its potential for contributing to local resilience and sustainability in the face of deindustrialization challenges is one of the best assets it has. This paper highlights the analysis of two case studies focused on the restoration of industrial heritage sites, namely the Sugar Mill “El Tarajal” in Malaga and the Trapiche del Prado in Marbella, conducted in collaboration between the University G. d’Annunzio of Chieti and Pescara and the University of Malaga. Four key concepts are identified: historical analysis and its impact on industrial evolution, production system transformations and their influence on buildings, the relationship between industry and its surroundings, and the impact of rehabilitation on the urban context. The recovery of industrial heritage goes beyond architectural preservation, emphasizing the importance of adapting these spaces for contemporary purposes and integrating modern technologies and sustainability approaches to drive socioeconomic revitalization. To address the vulnerabilities and lack of recognition faced by industrial heritage, a connection between research and education is discussed to disseminate knowledge among students and professionals in training. This approach aims to provide a more comprehensive and informed restoration process that considers the territorial scale, thereby translating assessment indicators into the design and preservation of industrial heritage sites.
Research on Pricing Methods of Convertible Bonds Based on Deep Learning GAN Models
Authors: Ren Gui , Meng Tao
Published: December 2023

This paper proposes two data-driven models (including LSTM pricing model, WGAN pricing model) and an improved model of LSM based on GAN to analyze the pricing of convertible bonds. In addition, the LSM model with higher precision in traditional pricing model is selected for comparative study with other pricing models. It is found that the traditional LSM pricing model has a large error in the first-day pricing, and the pricing function needs to be further improved. Among the four pricing models, LSTM pricing model and WGAN pricing model have the best pricing effect. The WGAN pricing model is better than the LSTM pricing model (0.21%), and the LSM improved model (1.17%) is better than the traditional LSM model (2.26%). Applying the generative deep learning model GAN to the pricing of convertible bonds can circumvent the harsh preconditions of assumptions, and significantly improve the pricing effect of the traditional model. The scope of application of each model is different. Therefore, this paper proves the feasibility of the GAN model applied to the pricing of convertible bonds, and enriches the pricing function of derivatives in the financial field.
Battery Electric Buses or Fuel Cell Electric Buses? A Decarbonization Case Study in the City of Brescia, Italy
Authors: Borghetti Fabio , Longo Michela , Bonera Michela , Libretti Marco , Somaschini Claudio , Martinelli Valentina , Medeghini Marco , Mazzoncini Renato
Published: December 2023

Nowadays, designing and adopting sustainable and greener transport systems is of upmost interest. The European Commission and different EU countries are developing plans and programs—but also delivering resources—aimed at the decarbonization of cities and transport by 2030. In this paper, the case study of the city of Brescia, a city of about 200,000 inhabitants located in northern Italy, is addressed. Specifically, a preliminary operational and financial feasibility study is performed assuming the replacement of the entire compressed natural gas (CNG) powered bus fleet of a specific line; the two alternatives considered are battery electric buses (BEBs) and fuel cell electric buses (FCEBs). For the comparison and evaluation of the two alternatives, specific economic parameters of the three alternatives (BEB, FCEB and the current solution CNGB) were considered: CAPEX (CAPital EXpenditure) and OPEX (OPerational EXpenditure). This allowed us to determine the TCO (total cost of ownership) and TCRO (total cost and revenues of ownership) along three annuities (2022, 2025 and 2030). For the BEB alternative, the TCO and TCRO values are between EUR 0.58/km and EUR 0.91/km. In the case of the FCEB solution, the values of TCO and TCRO are between EUR 1.75/km and EUR 2.15/km. Considering the current CNGB solution, the TCO and TCRO values range between EUR 1.43/km and EUR 1.51/km.
The PMT Acquisition and Trigger Generation System of the HEPD-02 Calorimeter for the CSES-02 Satellite
Authors: Mese Marco , Anastasio Antonio , Boiano Alfonso , Masone Vincenzo , Osteria Giuseppe , Perfetto Francesco , Panico Beatrice , Scotti Valentina , Vanzanella Antonio
Published: December 2023

This contribution describes the acquisition and trigger system for the HEPD-02 calorimeter that will be used onboard the CSES-02 satellite for the CSES/Limadou mission. This mission arises from the collaboration between the Chinese Space Agency (CNSA) and the Italian Space Agency (ASI) and plans the realization of a constellation of satellites which will monitor ionospheric parameters supposed to be related to earthquakes. It will also monitor the solar activity and the interaction with the magnetosphere and will study the cosmic rays in low energy ranges, extending data from PAMELA and AMS. The CSES-02 satellite will be equipped with various instruments, including the High-Energy Particle Detector (HEPD-02), which was designed to measure the energy of particles coming from Van Allen belts. Signals from the HEPD-02 are acquired and digitized by an electronic board that also produces the trigger for the experiment. A new generation ASIC (CITIROC) for the amplification, shaping and memorization of signals from PMTs will be used on this board. The new ASIC allows the use of the peak detector feature, optimizing the acquisition of signals with different temporal characteristics. Along with this, new algorithms for trigger generation have been developed, providing trigger pre-scaling, concurrent trigger masks and Gamma Ray Burst detection. Using pre-scaled concurrent triggers will allow the study of very sensitive regions of a satellite’s orbit such as the South Atlantic Anomaly and polar regions and to detect rare events such as GRBs while still monitoring particle bursts. In this contribution, the progress status of this work will be presented along with the measurements and tests made to finalize the flight model of the board.
Load Losses and Short-Circuit Resistances of Distribution Transformers According to IEEE Standard C57.110
Authors: León-Martínez Vicente , Peñalvo-López Elisa , Andrada-Monrós Clara , Sáiz-Jiménez Juan Ángel
Published: December 2023

Load losses determine transformers’ efficiency and life, which are limited by overheating and deterioration of their elements. Since these losses can be characterized by short-circuit resistances, in this article, we have developed expressions for the short-circuit resistances of three-phase transformers according to IEEE Standard C57.110. Imposing the condition that these resistances must cause load losses of the transformer, two types of short-circuit resistance have been established: (1) the effective resistance of each phase (Rcc,z) and (2) the effective short-circuit resistance of the transformer (Rcc,ef). The first is closely related to the power loss distribution within the transformer. The second is just a mathematical parameter. Applying these resistances to the 630 kVA oil-immersed distribution transformer of a residential network, we have concluded that both types of resistances determine the total load losses of the transformer. However, only Rcc,z accurately provides the load losses in each phase. Rcc,ef can give rise to errors more significant than 16% in calculating these losses, depending on imbalances in the harmonic currents.
Influence of the Apelinergic System on Conduction Disorders in Patients after Myocardial Infarction
Authors: Wyderka Rafał , Diakowska Dorota , Łoboz-Rudnicka Maria , Mercik Jakub , Borger Michał , Osuch Łukasz , Brzezińska Barbara , Leśków Anna , Krzystek-Korpacka Małgorzata , Jaroch Joanna
Published: December 2023

Background: There is a growing body of evidence for an important role of the apelinergic system in the modulation of cardiovascular homeostasis. The aim of our study was to (1) examine the relationship between apelin serum concentration at index myocardial infarction (MI) and atrioventricular conduction disorders (AVCDs) at 12-month follow-up, and (2) investigate the association between initial apelin concentration and the novel marker of post-MI scar (Q/QRS ratio) at follow-up. Methods: In 84 patients with MI with complete revascularization, apelin peptide serum concentrations for apelin-13, apelin-17, elabela (ELA) and apelin receptor (APJ) were measured on day one of hospitalization; at 12-month follow-up, 54 of them underwent thorough examination that included 12-lead electrocardiography (ECG), Holter ECG monitoring and echocardiography. Results: The mean age was 58.9 years. At 12-month follow-up, AVCDs were diagnosed in 21.4% of subjects, with AV first-degree block in 16.7% and sinoatrial arrest in 3.7%. ELA serum concentration at index MI correlated positively with the occurrence of AVCD (p = 0.003) and heart rate (p = 0.005) at 12-month follow-up. The apelin-13 serum concentration at index MI correlated negatively with the Q/QRS ratio. Conclusions: The apelin peptide concentration during an acute phase of MI impacts the development of AVCD and the value of Q/QRS ratio in MI survivors.
Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT
Authors: Palazon-Cabanes Ana , Palazon-Cabanes Begoña , Garcia-Medina Jose Javier , Alvarez-Sarrion Aurora , del-Rio-Vellosillo Monica
Published: December 2023

Background: This study aims to establish a reference for the superior–inferior hemisphere asymmetry in thickness values for all macular layers for the posterior pole algorithm (PPA) available for the Spectralis SD-OCT device. Methods: We examined 300 eyes of 300 healthy Caucasian volunteers aged 18–84 years using the PPA, composed of a grid of 64 (8 × 8) cells, to analyze the thickness asymmetries of the following automatically segmented macular layers: retinal nerve fiber layer (RNFL); ganglion cell layer (GCL); inner plexiform layer (IPL); inner nuclear layer (INL); outer plexiform layer (OPL); outer nuclear layer (ONL); retinal pigment epithelium (RPE); inner retina; outer retina; complete retina. Mean ± standard deviation and the 2.5th and 97.5th percentiles of the thickness asymmetry values were obtained for all the corresponding cells. Results: All the macular layers had significant superior–inferior thickness asymmetries. GCL, IPL, INL, ONL and RPE showed significantly greater thicknesses in the superior than the inferior hemisphere, whereas RNFL and OPL were thicker in the inferior hemisphere. The largest differences between hemispheres were for RNFL and ONL. Conclusions: This is the first normative database of macular thickness asymmetries for the PPA and should be considered to distinguish normal from pathological values when interpreting superior–inferior macular asymmetries.
Material Characterization Required for Designing Satellites from Fiber-Reinforced Polymers
Authors: Esha  , Hausmann Joachim
Published: December 2023

This review paper discusses the effect of polymers, especially thermoplastics, in environments with low earth orbits. Space weather in terms of low earth orbits has been characterized into seven main elements, namely microgravity, residual atmosphere, high vacuum, atomic oxygen, ultraviolet and ionization radiation, solar radiation, and space debris. Each element is discussed extensively. Its effect on polymers and composite materials has also been studied. Quantification of these effects can be evaluated by understanding the mechanisms of material degradation caused by each environmental factor along with its synergetic effect. Hence, the design elements to mitigate the material degradation can be identified. Finally, a cause-and-effect diagram (Ishikawa diagram) is designed to characterize the important design elements required to investigate while choosing a material for a satellite’s structure. This will help the designers to develop experimental methodologies to test the composite material for its suitability against the space environment. Some available testing facilities will be discussed. Some potential polymers will also be suggested for further evaluation.
An Investigation of the Damage Mechanism of Multilayer Liquid-Containing Protective Structure under Combined Blast Wave and Fragment Loading
Authors: Fan Zeqing , Li Xiaobin , Huang Tao , Chen Wei
Published: December 2023

A multilayer liquid-containing protective structure is composed of a liquid tank, ceramic, a honeycomb sandwich and homogeneous steel. This structure has superior resistance to combined blast wave and fragment loading. Due to the relatively complicated construction of the structure, the inner damage, energy absorption and the protection characteristics of the multilayer liquid-containing protective structure need to be further studied. In this paper, a multilayer liquid-containing structural model is constructed, the dynamic response process of multilayer liquid-containing structure under combined blast wave and fragment loading is analyzed, and the damage and energy absorption characteristics of each layer structure are investigated. In addition, the effects of the charge mass and fragment form on the structural failure modes and energy absorption characteristics are discussed. The results indicate that different modes of damage occur in each layer structure. The front plate of the liquid tank sustains the most damage and absorbs the most energy, and the honeycomb sandwich absorbs the second most energy. The damage area of the front plate and the degree of compression collapse of the honeycomb sandwich increase with increasing charge mass. When the charge mass is small, the damage mode of the multilayer liquid-containing structure is greatly affected by fragments, and the damage effect of the blast wave increases with increasing charge mass. For a constant charge mass, the degree of damage to the protective structure is minimally impacted by the fragment weight, and the degree of damage can be substantially reduced by reducing the number of fragments.
Effect of Speed and Hull Length on the Hydrodynamic Performance of a Semi-Planing Hull of a Shallow-Draft Watercraft
Authors: Leal-Ruiz Luis Daniel , Camargo-Díaz Clara Paola , Paipa-Sanabria Edwin , Castro-Faccetti Claudia , Candelo-Becerra John E.
Published: December 2023

Hydrodynamic performance is an essential factor in the design of a watercraft, and the navigation scenario determines the complexity of its operation. This study aims to identify the effect of speed and length on the hydrodynamic behavior of a semi-planing watercraft in shallow waters. A computational fluid dynamics tool was employed to predict the trim, heave, and resistance parameters of two different hulls: a base hull and a craft with an increased hull length. The two hulls had similar hydrodynamic characteristics. The effects of speed and hull length on these predicted parameters obtained for the two hulls were compared. The results showed a low resistance uncertainty and a reduction in dynamic trim for longer hull lengths. These findings highlight the importance of considering balance and dynamic trim in designing shallow-draft watercrafts to ensure an optimal performance in specific conditions, such as rivers with depth restrictions.
A Simultaneous Denitrification and Fermentation Process for Nitrate Removal in a Whiteleg Shrimp (Litopenaeus vannamei) Recirculating Aquaculture System: Using Endogenous Carbon from a Biofilm
Authors: Li Yayuan , Lu Shimin , Zhang Wang , Liu Xingguo , Jiang Haixin , Liu Chong , Yuan Zehui
Published: December 2023

During the process of circulating aquaculture, high concentrations of nitrate will accumulate. A simultaneous denitrification and fermentation process is described to remove nitrate from a recirculating aquaculture system using endogenous carbon on a biofilm. 15N isotope technology was used to assess the nitrate removal, mainly through heterotrophic denitrification. The nitrate removal rate could be as high as 98.97%, with a final concentration of nitrate below 1 mg/L. The denitrification process obeys a Michaelis–Menten-type enzyme kinetic model, with a half saturation constant of 99.91 mg/L and a maximum nitrate removal rate of 0.39 mg L−1 h−1 at 28 °C. The functional genes narG and narH for nitrate removal were obtained from Nitrospirae spp. at proportions of 39.13% and 26.16%, respectively. The acetate, propionate and iso-valerate produced by anaerobic fermentation provided the principal electron donors for denitrification.
UAV Relay Energy Consumption Minimization in an MEC-Assisted Marine Data Collection System
Authors: Xu Woping , Gu Li
Published: December 2023

Recently, unmanned aerial vehicle (UAV)-assisted maritime communication systems have drawn considerable attention due to their potential for broadband maritime communication applications. However, their limited energy resources remains a critical issue in providing long-term data transmission support for maritime applications. In this study, an integrated sea–air–terrestrial communication system was constructed for marine data collection, where several unmanned surface vessels (USVs) are deployed to collect marine data from underwater sensors (UWSs), and a UAV hovers above these USVs as a relay node, transmitting marine data from USVs to an onshore base station (BS). To prolong the lifetime of the UAV relay, mobile edge computing technology is applied in USVs for partial data computing, which reduces the to-be-relayed data volume from UAVs to USVs to onshore BS as well as the relay energy consumption of UAV. A parallel data computing and transmission scheme was developed for simultaneous local data computing and relaying in the proposed system. Accordingly, a UAV energy consumption minimization problem was formulated with constraints on the USV’s computational ability, the USV’s transmission power budget, the UAV transmission power budget, and the maximum system latency. To effectively solve this nonconvex optimal problem, an energy optimal partial data computing and relaying strategy was constructed by successively optimizing the data partial computational offloading ratio, USV transmit power allocation, and UAV transmit power. Numerical simulations were used to verify the effectiveness of the proposed strategy.
Selecting Appropriate Energy Source Options for an Arctic Research Ship
Authors: Palmén Mikael , Lotrič Ajda , Laakso Aleksi , Bolbot Victor , Elg Mia , Valdez Banda Osiris A.
Published: December 2023

Interest in more sustainable energy sources has increased rapidly in the maritime industry, and ambitious goals have been set for decreasing ship emissions. All industry stakeholders have reacted to this with different approaches including the optimisation of ship power plants, the development of new energy-improving sub-systems for existing solutions, or the design of entirely novel power plant concepts employing alternative fuels. This paper assesses the feasibility of different ship energy sources for an icebreaking Arctic research ship. To that end, possible energy sources are assessed based on fuel, infrastructure availability and operational endurance criteria in the operational area of interest. Promising alternatives are analysed further using the evidence-based Strengths, Weaknesses, Opportunities, and Threats (SWOT) method. Then, a more thorough investigation with respect to the required fuel tank space, life cycle cost, and CO2 emissions is implemented. The results demonstrate that marine diesel oil (MDO) is currently still the most convenient solution due to the space, operational range, and endurance limitations, although it is possible to use liquefied natural gas (LNG) and methanol if the ship’s arrangement is radically redesigned, which will also lead to reduced emissions and life cycle costs. The use of liquefied hydrogen as the only energy solution for the considered vessel was excluded from the potential options due to low volumetric energy density, and high life cycle and capital costs. Even if it is used with MDO for the investigated ship, the reduction in CO2 emissions will not be as significant as for LNG and methanol, at a much higher capital and lifecycle cost. The advantage of the proposed approach is that unrealistic alternatives are eliminated in a systematic manner before proceeding to detailed techno-economic analysis, facilitating the decision-making and investigation of various options in a more holistic manner.
Benefits of the Erector Spinae Plane Block before Cryoanalgesia in Children Undergoing Surgery for Funnel Chest Deformity
Authors: Zacha Sławomir , Jarosz Konrad , Kokot Karolina , Biłas Jarosław , Skonieczna-Żydecka Karolina , Gerus Sylwester , Kojder Klaudyna , Biernawska Jowita
Published: December 2023

Thoracic surgery causes significant pain despite standard multimodal analgesia. Intraoperative cryoanalgesia may be a solution. The onset of the clinical effect of cryoanalgesia can take 12–36 h. The addition of a regional anaesthesia before the cryoanalgesia procedure can enable analgesic protection for the patient during this period. The main aim of the study was to evaluate the benefits of the erector spinae plane (ESP) block prior to Nuss surgery. The ‘control’ group consisted of 10 teenagers who underwent cryoablation together with intravenous multimodal analgesia according to the standard protocol. The ‘intervention’ group included 26 teenage patients who additionally received an erector spinae plane block before operation. Pain relief (p = 0.015), opioid use (p = 0.009), independent physical activity and rehabilitation (p = 0.020) were faster in the intervention group. No features of local anaesthetic drug toxicity or complications of the ESP block were observed. The bilateral ESP block together with intraoperative intercostal nerve cryoablation performed prior to Nuss correction of funnel chest were more effective in terms of pain control.
A Review of the Lidocaine in the Perioperative Period
Authors: Silva Abigail , Mourão Joana , Vale Nuno
Published: December 2023

This review analyzes the controversies surrounding lidocaine (LIDO), a widely recognized local anesthetic, by exploring its multifaceted effects on pain control in the perioperative setting. The article critically analyzes debates about lidocaine’s efficacy, safety, and optimal administration methods. While acknowledging its well-documented analgesic attributes, the text highlights the ongoing controversies in its application. The goal is to provide clinicians with a comprehensive understanding of the current discourse, enabling informed decisions about incorporating lidocaine into perioperative protocols. On the other hand, emphasizes the common uses of lidocaine and its potential role in personalized medicine. It discusses the medication’s versatility, including its application in anesthesia, chronic pain, and cardiovascular diseases. The text recognizes lidocaine’s widespread use in medical practice and its ability to be combined with other drugs, showcasing its adaptability for individualized treatments. Additionally, it explores the incorporation of lidocaine into hyaluronic acid injections and its impact on pharmacokinetics, signaling innovative approaches. The discussion centers on how lidocaine, within the realm of personalized medicine, can offer safer and more comfortable experiences for patients through tailored treatments.
The Impact of COVID-19 on the Internationalization Performance of Family Businesses: Evidence from Portugal
Authors: Roque Ana , Alves Maria-Ceu
Published: December 2023

Drawing on the internationalization and family business literature, this preliminary and exploratory study examines the impact of the COVID-19 pandemic on the internationalization performance of family firms. To the best of our knowledge, this is the first study to analyze the impact of COVID-19 on the internationalization strategy of Portuguese family firms. Using a questionnaire survey of private family firms, this paper adopts a quantitative approach. Our analysis of data from a single survey of 127 family firms shows that these firms mostly use the Uppsala model of internationalization. The results indicate that COVID-19 has a very negative and statistically significant impact on the different components of the internationalization performance of family businesses. This study contributes significantly to a better understanding of the impact of uncertainty caused by epidemiological scenarios on the strategy and performance of family firms.
Nutrients and Contaminants in Soils of Current and Former Oil Palm Production Systems from Indonesia
Authors: Thompson-Morrison Hadee , Ariantiningsih Fransisca , Arief Sugesti Muhammad , Gaw Sally , Robinson Brett
Published: December 2023

Palm oil production in Southeast Asia often occurs on nutrient-poor, acidic soils converted from primary forest. Both the agricultural conversion and the production of oil palm are subsidised in Indonesia. As well as depleting soil organic C and plant nutrients, agricultural production on these soils can result in the accumulation of trace elements (TEs)—including micronutrients and non-essential trace elements—from the use of TE-containing agrichemicals including phosphate fertilisers and Cu fungicides. We tested the hypothesis that palm soils will have lower C concentrations than forest soils, as well as accumulation of TEs including Cu, Zn and Cd. Soil samples from active and abandoned oil palm plantations in Sumatra, Indonesia, were analysed for general soil properties as well as TE concentrations. Soils were acidic and low in key nutrients, with production likely to be limited by deficiencies of N, P, K, Mg and Mo, present at some sites in mean concentrations as low as 0.021%, 118 mg kg−1, 778 mg kg−1, 1023 mg kg−1 and 0.095 mg kg−1, respectively. Mean organic C was lower (2.0–3.3%) than reported values in nearby forest soils (7.7%). Soils under palm production contained elevated levels of Cu, Zn, As and Pb up to 38, 91, 9.0 and 28 mg kg−1, respectively, likely due to agrichemical use. The correction of nutrient deficiencies in palm production would require significant fertiliser inputs, which would exacerbate TE accumulation and reduce the net economic revenue from oil production. Our data have shown that in the plantations we have sampled, soils have become degraded. These tropical, weathered, and naturally nutrient-poor soils are ill suited to intensive production that requires high ongoing nutrient inputs. These findings have implications for the sustainability of a regionally significant production system across Southeast Asia.
Social Enterprises and Their Role in Revitalizing Shrinking Cities—A Case Study on Shimizusawa of Japan
Authors: Liu Jian , Zhang Yixin , Mao Junsong
Published: December 2023

Since their birth in the 1990s, social enterprises, as a kind of third-party organization with the attributes of both a not-for-profit entity and a profit-making enterprise, have played a significant role in the socio-economic development of cities, in particular those facing the challenge of shrinking. But why are social enterprises so deeply embedded in the regeneration process of shrinking cities, and how do they promote their multi-dimensional revitalization? In order to answer these questions, this paper presents a case study on Shimizusawa in Japan based on a literature review and field research. In line with the embeddedness and institution–function–instrument theories, it reviews the revitalization of Shimizusawa by involving a social enterprise in the adaptive reuse of industrial heritage sites and the development of industrial tourism, analyzes the establishment process and organizational characteristics of this social enterprise, and summarizes the four major experiences of its practice—that is, the governance structure of two types of institutions and two types of functions, the planning for both profitable and non-profitable activities, the operation of both for-profit and not-for-profit businesses, and the fund management of leveraging multiple parties to raise funds and reinvesting the profits locally. The extensive support provided by the Shimizusawa Social Enterprise that creates not only economic value but also social value justifies the significant role of social enterprises in the revitalization of shrinking industrial areas. This case study, together with its analytical framework, may serve as a meaningful reference for the revitalization of shrinking industrial areas in other parts of the world.
Rapid Land Cover Classification Using a 36-Year Time Series of Multi-Source Remote Sensing Data
Authors: Yan Xingguang , Li Jing , Smith Andrew R. , Yang Di , Ma Tianyue , Su Yiting
Published: December 2023

Long time series land cover classification information is the basis for scientific research on urban sprawls, vegetation change, and the carbon cycle. The rapid development of cloud computing platforms such as the Google Earth Engine (GEE) and access to multi-source satellite imagery from Landsat and Sentinel-2 enables the application of machine learning algorithms for image classification. Here, we used the random forest algorithm to quickly achieve a time series land cover classification at different scales based on the fixed land classification sample points selected from images acquired in 2022, and the year-by-year spectral differences of the sample points. The classification accuracy was enhanced by using multi-source remote sensing data, such as synthetic aperture radar (SAR) and digital elevation model (DEM) data. The results showed that: (i) the maximum difference (threshold) of the sample points without land class change, determined by counting the sample points of each band of the Landsat time series from 1986 to 2022, was 0.25; (ii) the kappa coefficient and observed accuracy of the same sensor from Landsat 8 are higher than the results of the TM and ETM+ sensor data from 2013 to 2022; and (iii) the addition of a mining land cover type increases the kappa coefficient and overall accuracy mean values of the Sentinel 2 image classification for a complex mining and forest area. Among the land classifications via multi-source remote sensing, the combined variables of Spectral band + Index + Terrain + SAR result in the highest accuracy, but the overall improvement is limited. The method proposed is applicable to remotely sensed images at different scales and the use of sensors under complex terrain conditions. The use of the GEE cloud computing platform enabled the rapid analysis of remotely sensed data to produce land cover maps with high accuracy and a long time series.
Ecosystem Service Value Changes in Response to Land Use Dynamics in Lithuania
Authors: Sujetovienė Gintarė , Dabašinskas Giedrius
Published: December 2023

Changes in land cover affect ecosystems and the services they provide. The aim of this study was to assess the spatial changes in land use from 1990 to 2018 and analyze the changes in ecosystem service value (ESV) in response to the changes in landscape structure in Lithuania. Croplands provided the majority of the ESV, followed by forests, grasslands, and wetlands. The total ESV in Lithuania was USD 29 billion year−1 in 2018, and land use had a significant impact on ESV, with a total decrease of USD 438 million year−1 between 1990 and 2018. The total ESV change was mainly influenced by the decrease in provisioning (USD 426 million year−1) and regulating (USD 208 million year−1) services. The reduction in cropland area was a major factor in the loss of ESV. The increase in the value of habitat and cultural services was not large enough to offset the reduction of the ESV. The highest elasticities were in the urban municipalities, indicating a significant change in ESV due to land use change. The results of this study provide valuable insight into the potential of the sustainable management and regeneration of ecosystems.
Hydatidiform Mole—Between Chromosomal Abnormality, Uniparental Disomy and Monogenic Variants: A Narrative Review
Authors: Florea Andreea , Caba Lavinia , Grigore Ana-Maria , Antoci Lucian-Mihai , Grigore Mihaela , Gramescu Mihaela I. , Gorduza Eusebiu Vlad
Published: December 2023

A hydatidiform mole (HM) or molar pregnancy is the most common benign form of gestational trophoblastic disease characterized by a proliferation of the trophoblastic epithelium and villous edema. Hydatidiform moles are classified into two forms: complete and partial hydatidiform moles. These two types of HM present morphologic, histopathologic and cytogenetic differences. Usually, hydatidiform moles are a unique event, but some women present a recurrent form of complete hydatidiform moles that can be sporadic or familial. The appearance of hydatidiform moles is correlated with some genetic events (like uniparental disomy, triploidy or diandry) specific to meiosis and is the first step of embryo development. The familial forms are determined by variants in some genes, with NLRP7 and KHDC3L being the most important ones. The identification of different types of hydatidiform moles and their subsequent mechanisms is important to calculate the recurrence risk and estimate the method of progression to a malign form. This review synthesizes the heterogeneous mechanisms and their implications in genetic counseling.
Antifibrotic Agents in Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Systematic Review and Meta-Analysis
Authors: Jang Ji Hoon , Ko Junghae , Jung So Young , Kim Dae-Wook , Oh Ju Hyun , Kim Tae-Jung , Park Joo Hun , Choi Miyoung , Lee Jae Ha
Published: December 2023

Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a common extra-articular clinical manifestation of rheumatoid arthritis (RA) that has negative impacts on morbidity and mortality. In addition, there has been no proven treatment for RA-ILD to date. Thus, we planned a meta-analysis of a literature search to confirm the clinical effects of antifibrotic agents in RA-ILD patients. Materials and Methods: We conducted the literature search in Ovid MEDLIVE® databases, Cochrane Library databases, EMBASE, and KoreaMed and identified references elucidating the role of nintedanib or pirfenidone in adult patients with RA-ILD. Among the identified studies, those with comparative interventions, complete results of clinical trials, and available full text were included in the analysis. The primary outcome was the effect of the antifibrotic agent on disease progression in RA-ILD patients assessed with a mean difference in the change of forced vital capacity (FVC) and the proportion of patients with an increase in percent predicted FVC of 10% or more over 52 weeks. Analysis for heterogeneity was assessed through I2 statistics. Meta-analysis with a fixed effect model was performed on changes in FVC. Results: A total of 153 articles were identified through database searches, of which 28 were excluded because of duplication. After additional screening, 109 studies were selected with full text and two articles qualified for analysis according to the set inclusion and exclusion criteria. As a result, two randomized controlled studies were selected, comparing nintedanib and pirfenidone to placebo, respectively. The meta-analysis revealed that antifibrotic agents showed a significant reduction in FVC decline compared to placebo in patients with RA-ILD (mean difference, 88.30; 95% CI, 37.10–139.50). Additionally, there were significantly fewer patients experienced an increase in percent predicted FVC of 10% or more in the antifibrotic agent group compared to the placebo group (Odds ratio 0.42; 95% CI 0.19–0.95, p = 0.04). There was no significant heterogeneity between the two included studies (χ2 = 0.35, p = 0.0007, I2 = 0%). Conclusions: The meta-analysis suggests that nintedanib and pirfenidone may have clinical utility in reducing disease progression in patients with RA-ILD. Further research is needed to confirm the clinical benefits of antifibrotic agents in RA-ILD.
Assessment of the Microbiological Safety and Hygiene of Raw and Thermally Treated Milk Cheeses Marketed in Central Italy between 2013 and 2020
Authors: Primavilla Sara , Roila Rossana , Rocchegiani Elena , Blasi Giuliana , Petruzzelli Annalisa , Gabucci Claudia , Ottaviani Donatella , Di Lullo Stefania , Branciari Raffaella , Ranucci David , Valiani Andrea
Published: December 2023

A profile of the microbial safety and hygiene of cheese in central Italy was defined based on an analysis of 1373 cheeses sampled under the Italian National Control Plan for Food Safety spanning the years 2013 to 2020 and tested according to Commission Regulation (EC) No. 2073/2005 (as amended). A total of 97.4% of cheese samples were assessed as being satisfactory for food safety criteria and 80.5% for process hygiene criteria. Staphylococcal enterotoxin was found in 2/414 samples, while Salmonella spp. and Listeria monocytogenes were detected in 15 samples out of 373 and 437, respectively. Escherichia coli and coagulase-positive staphylococci counts were found unsatisfactory in 12/61 and 17/88 cheese samples, respectively. The impact of milking species, milk thermal treatment, and cheese hardness category was considered. A statistically significant association (p < 0.05) was found between milk thermal treatment and the prevalence of coagulase-positive staphylococci and Listeria monocytogenes and between hardness and unsatisfactory levels of Escherichia coli. The data depict a contained public health risk associated with these products and confirm, at the same time, the importance of strict compliance with good hygiene practices during milk and cheese production. These results can assist in bolstering risk analysis and providing insights for food safety decision making.
MoS2 Nanomaterials as Lubricant Additives: A Review
Authors: Lu Ziyan , Lin Qingqing , Cao Zhaotao , Li Wanyuan , Gong Junjie , Wang Yan , Hu Kunhong , Hu Xianguo
Published: December 2023

Improving the lubricating properties of base oils through additives is a crucial objective of tribological research, as it helps to reduce friction and wear of materials. Molybdenum disulfide (MoS2) is a 2D nanomaterial with excellent tribological properties that is often used as a lubricant additive. Several studies have been conducted on the preparation and utilization of MoS2 and its nanocomposites as lubricant additives. This paper reviews the research progress on MoS2 nanomaterials as lubricant additives. It firstly introduces various synthesis methods of MoS2 nanomaterials while focusing on the preparation of nano-MoS2 as lubricant additives. It then summarizes the dispersion stability of nano-MoS2 in lubricating oils which has been paid extensive attention. Moreover, this paper reviews and discusses the tribological properties of nano-MoS2 and its various composites as lubricant additives. The possible anti-wear and friction reduction mechanisms of nano-MoS2 and its composites are also discussed. Finally, this paper presents the challenges faced by nano-MoS2 additives in the field of lubrication and the prospects for future research in view of previous studies.
Conditions for the Oscillation of Solutions to Neutral Differential Equations of Higher Order
Authors: Al-Kandari Maryam
Published: December 2023

In this research, we applied three techniques—the comparison technique, the Riccati technique, and the integral averages technique to analyze and establish various conditions and properties associated with the oscillatory behavior of even-order neutral differential equations. These findings contribute to a better understanding of the dynamics of such equations. To demonstrate the efficacy of these new conditions and properties, we present illustrative examples. This study offers valuable insights into the behavior of neutral differential equations, advancing our knowledge in this field.
Designing a Renewable Jet Fuel Supply Chain: Leveraging Incentive Policies to Drive Commercialization and Sustainability
Authors: Ebrahimi Sajad , Szmerekovsky Joseph , Golkar Bahareh , Haji Esmaeili Seyed Ali
Published: December 2023

Renewable jet fuel (RJF) production has been recognized as a promising approach for reducing the aviation sector’s carbon footprint. Over the last decade, the commercial production of RJF has piqued the interest of airlines and governments around the world. However, RJF production can be challenging due to its dispersed supply resources. Furthermore, the production of RJF is more costly compared to producing conventional jet fuel. In this study, using a mixed integer linear programming (MILP), we design a corn-stover-based RJF supply chain network in which we obtain an optimized configuration of the supply chain and determine operational decisions required to meet RJF demand at airports. To accelerate the commercialization of RJF production, we examined four incentive programs designed to cover the supply chain’s costs, with agricultural statistics districts serving as the designated supply regions. This study is validated by employing the model to design the supply chain in the Midwestern United States. The results from this study are promising as they show the supply chain can achieve commercialization with partial financial coverage from the incentive programs. Based on the findings of this study, policymakers can devise policies to commercialize RJF production and accelerate its adoption by the industry.
Kinetics of Aluminum and Scandium Extraction from Desilicated Coal Fly Ash by High-Pressure HCl Leaching
Authors: Shoppert Andrei , Valeev Dmitry , Loginova Irina
Published: December 2023

Coal fly ash (CFA) is a waste that forms via coal combustion in thermal power stations. CFA consists of numerous components, whose recovery can address environmental and resource concerns associated with sustainable development. Most of the alumina (Al2O3) and rare-earth elements (REEs) in CFA are contained in the amorphous glassy mass and in the refractory mullite phase (3Al2O3·SiO2), which can be dissolved only using high-pressure acid leaching (HPAL). In this paper, the method of preactivation of CFA by treatment with a highly concentrated NaOH solution is used to increase the efficiency of Al and Sc extraction during HPAL. This method allows for the elimination of an inert aluminosilicate layer from the surface of mullite, transferring the REEs into an acid-soluble form. The Al and Sc extraction can reach 80% after HCl HPAL at T = 170 °C and a 90 min duration. According to the kinetic data, the dissolution of Al follows the surface chemical reaction and intraparticle diffusion shrinking core models in the initial and later stages of leaching, respectively. A high activation energy of 52.78 kJ mol−1 was observed at low temperatures, and a change in the mechanism occurred after 170 °C when the activation energy decreased to 26.34 kJ mol–1. The obtained activation energy value of 33.51 kJ mol−1 for Sc leaching indicates that diffusion has a strong influence at all studied temperatures. The residue was analysed by SEM-EDX, XRF, BET, and XRD methods in order to understand the mechanism of DCFA HPAL process.
The Contribution of Hormonal Changes to the Protective Effect of Endophytic Bacterium Bacillus subtilis on Two Wheat Genotypes with Contrasting Drought Sensitivities under Osmotic Stress
Authors: Lastochkina Oksana , Yuldashev Ruslan , Avalbaev Azamat , Allagulova Chulpan , Veselova Svetlana
Published: December 2023

A comparative analysis was conducted to evaluate the effects of seed priming with endophytic bacterium Bacillus subtilis 10-4 (BS) on the hormonal system and cell wall tolerance (lipid peroxidation (LPO), electrolyte leakage (EL), and root lignin deposition) of two Triticum aestivum L. (wheat) varieties with contrasting drought sensitivities (Ekada 70—drought-tolerant (DT); Salavat Yulaev—drought-sensitive (DS)) under normal conditions and 12% polyethylene glycol-6000 (PEG)-induced osmotic stress. The results showed that under normal conditions, the growth stimulation in wheat plants by BS was attributed to changes in the hormonal balance, particularly an increase in endogenous indole-3-acetic acid (IAA) accumulation. However, under stress, a significant hormonal imbalance was observed in wheat seedlings, characterized by a pronounced accumulation of abscisic acid (ABA) and a decrease in the levels of IAA and cytokinins (CK). These effects were reflected in the inhibition of plant growth. BS exhibited a protective effect on stressed plants, as evidenced by a significantly lower amplitude of stress-induced changes in the hormonal system: maintaining the content of IAA at a level close to the control, reducing stress-induced ABA accumulation, and preventing CK depletion. These effects were further reflected in the normalization of growth parameters in dehydrated seedlings, as well as a decrease in leaf chlorophyll degradation, LPO, and EL, along with an increase in lignin deposition in the basal part of the roots in both genotypes. Overall, the findings demonstrate that BS, producing phytohormones, specifically IAA and ABA, had a more pronounced protective effect on DT plants, as evidenced by a smaller amplitude of stress-induced hormonal changes, higher leaf chlorophyll content, root lignin deposition, and lower cell membrane damage (LPO) and permeability (EL) compared to DS plants.
Natural Products and Cancer
Authors: Matsuo Yoichi
Published: December 2023

Natural and dietary compounds are known to offer protection and affect the pathogeneses of numerous chronic diseases [...]