bluuebunny/crossref_metadata_2025 huggingface dataset:
Aerial Image Segmentation with Clustering Using Fireworks Algorithm
Authors: Arasy Muhammad Hariz , Suyanto Suyanto , Ramadhani Kurniawan Nur
Published: March 2019

Aerial images has different data characteristics when compared to other types of images. An aerial image usually contains small insignificant objects that can cause errors in the unsupervised segmentation method. K-means clustering, one of the widely used unsupervised image segmentation methods, is highly vulnerable to local optima. In this study, Adaptive Fireworks Algorithm (AFWA) is proposed as an alternative to the K-means algorithm in optimizing the clustering process in the cluster-based segmentation method. AFWA is then applied to perform aerial image segmentation and the results are compared with K-means. Based on the comparison using Probabilistic Rand Index (PRI) and Variation of Information (VI) evaluation metrics, AFWA produces an overall better segmentation quality.
An enthalpy-based finite element method for solving two-phase Stefan problem
Authors: Tarwidi Dede
Published: March 2019

Stefan problem is a problem involving phase transition from solid to liquid or vice versa where boundary between solid and liquid regions moves as function of time. This paper presents numerical solution of one-dimensional two-phase Stefan problem by using finite element method. The governing equations involved in Stefan problem consist of heat conduction equation for solid and liquid regions, and also transition equation in interface position (moving boundary). The equations are difficult to solve by ordinary numerical method because of the presence of moving boundary. As consequence, the equations is reformulated into the form of internal energy (enthalpy). By the enthalpy formulation, solution of the heat conduction equations is no longer concerning the phase state of material. The advantage of the enthalpy formulation is that, finite element method can be easily implemented to solve Stefan problem. Numerical simulation of interface position, temperature profile, and temperature history has good agreement with the exact solution. The approximation of interface position using finite element method was found that it is more accurate than the approximation by using Godunov method. The simulation results also reveal that the finite element method for solving Stefan problem have smaller mean absolute error than the Godunov method.
Implicit Boundary Integral Method for Homogeneous Hele-Shaw Problem with multi-connected Domain
Authors: Palupi Irma
Published: March 2019

In this work, we implement the implicit boundary integral method for a homogeneous Hele-Shaw problem with a multi-connected domain. This method base on the solution of layer potential integral for the Laplace equation. The numerical technique is easy to implement, base on the idea of averaging the parameterization near the boundary and applying the Coarea formula. This technique changes the boundary integral into the Riemann integral that numerically easy to compute. The difficulty in the computation of hypersingular integral occurs to compute the normal velocity of free boundary. We use a collocation technique to eliminate the hypersingular part in the integral equation. Also, we show the numerical results and its computation performance due to the appearance of a non-invertible matrix.
Effect of sheep’s genotype and grazing site on haematological and redox status indicators
Authors: PATKOWSKI KRZYSZTOF , OGNIK KATARZYNA , KULIK MARIUSZ , GREGUŁA-KANIA MONIKA , GRUSZECKI TOMASZ M.
Published: March 2019

The aim of the study was to determine the effect of sheep’s genotype and grazing site on their hematological and redox status indicators. The experiment was carried out on sheep of the Świniarka and Uhruska breeds grazed in naturally valuable areas (xerothermic grasslands) and kept in a sheepfold. Several blood indices were determined by ABACUS Junior Vet, including the numbers of leukocytes, thrombocytes and erythrocytes, hemoglobin and procalcitonin concentrations, hematocrit, the mean red cell volume and the average hemoglobin concentration in red blood cells, the percentages of lymphocytes, monocytes and granulocytes, the degree of erythrocyte anisocytosis and the degree of variation in platelet volume. The concentrations of lipid peroxides and malonic dialdehyde, the activity of superoxide dismutase and catalase and total antioxidant potential were determined by spectrophotometric methods. The study showed that Świniarka sheep had a greater antioxidant potential and higher white blood cell counts than Uhrusian sheep. It was found that sheep’s grazing place had a significant influence on the antioxidant status and hematological indicators of their blood. An improvement in antioxidant potential and hematological blood parameters was achieved in sheep grazed in naturally valuable areas, that is, in the Stawska Góra nature reserve and on xerothermic grasslands in Gródek and Kąty, compared to sheep fed in a sheepfold.
Neospora caninum infection in cattle: Not only an economic problem
Authors: KIERBIĆ ALEKSANDRA , WIECZORKIEWICZ MARIA , ŻBIKOWSKA* ELŻBIETA , JAŚKOWSKI JĘDRZEJ M.
Published: March 2019

Neosporosis is an infectious disease of cattle and other species with a worldwide distribution. In Poland, the seropositivity rate for N. caninum among dairy cattle varies between 6% and 80%, with the highest number of seropositive cows in central and north-eastern voivodeships. In the United States, in 2003 the total annual cost of N. caninum infections was 657 million dollars, and in Great Britain in 2014 it was nearly 14 million pounds. N. caninum results in severe economic losses caused by a decreased milk yield, an increased number of culled cows, a higher newborn calf mortality rate and occasional birth defects. However, the most common result of this disease is abortion, which usually occurs between the 5th and 7th month of gestation. The risk of aborting is 3 times as high for seropositive cows as it is for seronegative cows; up to 21.6% vs. 7.3%, respectively. Cattle can become infected by consuming food and water contaminated with N. caninum oocysts, but the principal route is transplacental transmission usually between the 70th and 210th day of gestation. The ELISA test is most often used to detect the presence of specific antibodies in blood serum. PAG-2 level in the bloodstream can be a good marker for predicting Neospora-induced abortions – in seropositive cows, a level of more than 4.5 ng/ml on the 120th day of gestation means a 7-fold higher risk of pregnancy loss. According to research, live attenuated vaccines are highly efficacious in preventing neosporosis. Unfortunately, the currently available methods of prevention are based on the elimination of seropositive cows from the herd and the limitation of contact with the final hosts of N. caninum.
Feasibility of solar-powered ultrafiltration membrane water treatment systems for rural water supply in Malaysia
Authors: Chew Chun Ming , David Ng K. M.
Published: March 2019

According to the World Bank's collection of development indicators, in 2017 approximately 25% of Malaysia's population were living in rural villages. Some of these villages are currently without electricity from the national grid and public piped water supply. In this study, a solar-powered ultrafiltration membrane water treatment system was installed at a rural village in Perak, Malaysia, to identify its feasibility. The ultrafiltration system was evaluated and compared with a conventional sand/media filtration water treatment system at the same location. Various aspects of both systems such as operational parameters, life-cycle cost and carbon emissions have been analyzed under this study. The distinct advantages of the ultrafiltration system include better filtrate turbidity quality (below 0.4 NTU), and lower operational cost and carbon emission. By utilizing a cross-flow filtration operation mode, the UF system does not require a daily intermittent backwash sequence, unlike the conventional system, to further simplify the daily operational routine. Accessibility of clean water supply for all has been heavily emphasized by the United Nations General Assembly (under sustainable development goal number 6) to ensure public health. This comprehensive study highlights the feasibilities of solar-powered ultrafiltration membrane water treatment systems for rural villages in Malaysia.
3D Printing in Pharmaceuticals: Regulatory Perspective
Authors: Mirza Mohd. A. , Iqbal Zeenat
Published: March 2019

Background:

The last few decades have witnessed enormous advancements in the field of Pharmaceutical
drug, design and delivery. One of the recent developments is the advent of 3DP technology. It has earlier
been successfully employed in fields like aerospace, architecture, tissue engineering, biomedical research, medical
device and others, has recently forayed into the pharmaceutical industry.Commonly understood as an additive
manufacturing technology, 3DP aims at delivering customized drug products and is the most acceptable form
of“personalized medicine”.

Methods:

Data bases and search engines of regulatory agencies like USFDA and EMA have been searched thoroughly
for relevant guidelines and approved products. Other portals like PubMed and Google Scholar were also
ferreted for any relevant repository of publications are referred to wherever required.

Results:

So far only one pharmaceutical product has been approved in this category by USFDA and stringent
regulatory agencies are working over the drafting of guidelines and technical issues. Major research of this
category belongs to the academic domain.

Conclusion:

It is also implicit to such new technologies that there would be numerous challenges and doubts
before these are accepted as safe and efficacious. The situation demands concerted and cautious efforts to bring in
foolproof regulatory guidelines which would ultimately lead to the success of this revolutionary technology.
Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins
Authors: Tan Huanbo , Su Wencheng , Zhang Wenyu , Wang Pengju , Sattler Michael , Zou Peijian
Published: March 2019

Peptides and proteins are two classes of molecules with attractive possibilities for therapeutic applications. However, the bottleneck for the therapeutic application of many peptides and proteins is their short halflives in vivo, typically just a few minutes to hours. Half-life extension strategies have been extensively studied and many of them have been proven to be effective in the generation of long-acting therapeutics with improved pharmacokinetic and pharmacodynamic properties. In this review, we summarize the recent advances in half-life extension strategies, illustrate their potential applications and give some examples, highlighting the strategies that have been used in approved drugs and for drugs in clinical trials. Meanwhile, several novel strategies that are still in the process of discovery or at a preclinical stage are also introduced. In these strategies, the two most frequently used half-life extension methods are the reduction in the rate of renal clearance or the exploitation of the recycling mechanism of FcRn by binding to the albumin or IgG-Fc. Here, we discuss half-life extension strategies of recombinant therapeutic protein via genetic fusion, rather than chemical conjugation such as PEGylation. With the rapid development of genetic engineering and protein engineering, novel strategies for half-life extension have been emerged consistently. Some of these will be evaluated in clinical trials and may become viable alternatives to current strategies for making next-generation biodrugs.
Rosuvastatin Attenuated Elastic Fiber Degradation in Chronic Obstructive Pulmonary Disease Sprague-Dawley Rats
Authors: Sabirin Rahmaningsih Mara , - Prasetyastuti , Agustiningsih Denny
Published: March 2019

Chronic obstructive pulmonary disease (COPD) is an incurable disease which causes disability and death. The main pathogenesis of COPD is oxidative stress due to cigarette smoke which initiates various reactions and lead to lung elastic fibers destruction. Statins are known to have antioxidant effects and reduce mortality in COPD. We studied the effects of cigarette smoke exposure cessation and rosuvastatin on oxidative stress and the level of elastic fiber destruction in COPD model rats. Thirty 10-week old male Sprague-Dawley rats were divided into 2 groups: Control (n=6, did not received fumigation nor treatment) and Smoking (n=24, received fumigation for 70 days) groups. Afterwards, the smoking group was divided into 4 groups: Sham, R2, R5,R10, and received 0.9% NaCl, 2.5, 5 and 10 mg/kg/day of rosuvastatin, respectively. Examination of malondialdehyde (MDA) and desmosine serum were conducted to measure oxidative stress and elastic fiber degradation level, respectively. After smoke exposure, MDA and desmosine levels of COPD rats were found to be significantly higher (p=0.000 and 0.000) than controls. The MDA level in Sham, R2, R5 and R10 groups decreased significantly after therapy (p=0.000; 0.033; 0.015; 0.002). However, the post-treatment desmosine level was increase significantly in Sham and R2 groups (p=0.006 dan 0.012) and insignificantly (p=0.117 dan 0.278) in the R5 and R10 groups. It can be concluded that the cessation of exposure to cigarette smoke can reduce oxidative stress, but not elastic degradation process. The administration of rosuvastatin of 5 or 10 mg/kg/day attenuated elastic degradation process.
ФАРМАКОКОРЕКЦІЯ КРІОГЛОБУЛІНЕМІЇ ПРИ АЛЕРГІЧНИХ ДЕРМАТОЗАХ ІЗ СУПУТНЬОЮ ЦИТОМЕГАЛОВІРУСНОЮ ІНФЕКЦІЄЮ
Authors: Бакалець О. В. , Мудра А. Є. , Олещук О. М.
Published: March 2019

Наявність алергічного дерматозу у 85 % пацієнтів призводить до розвитку кріоглобулінемічного синдрому незалежно від супутнього інфікування цитомегаловірусом. Тривалість супутнього вірусного процесу впливає на рівень кріоглобулінів (найнижчий він у хворих з наявністю лише анти-ЦМВ IgM). Традиційна антиалергічна терапія виявляється ефективною щодо кріопреципітації лише у пацієнтів без супутньої вірусної патології, а поєднання її з противірусним та імуномодулюючим середниками – при наявності супутньої цитомегаловірусної інфекції.

Ключові слова: кріоглобулінемія, цитомегаловірус, алергічний дерматоз
ДІАГНОСТИЧНА ЦІННІСТЬ КОМП'ЮТЕРНОЇ ТОМОГРАФІЇ ТА МАГНІТНО-РЕЗОНАНСНОЇ ТОМОГРАФІЇ ПРИ МІСЦЕВИХ УСКЛАДНЕННЯХ ГОСТРОГО ПАНКРЕАТИТУ
Authors: Ціфринець О. І. , Денисенко В. М.
Published: March 2019

Гострий панкреатит (ГП) – первинно-асептичне запалення демаркаційного характеру, в основі якого лежать процеси некробіозу панкреатоцитів, ферментативної, оксидантної аутоагресії з наступним розвитком некрозу, дегенерації підшлункової залози (ПЗ), ураженням життєво-важливих органів і наступним приєднанням гнійної інфекції.

ГП є частою причиною гострого живота і його ускладнень, які, в результаті, можуть призвести до смерті. Найбільш частою причиною ГП є біліарний калькульозний холецистит та зловживання алкоголем. Комп'ютерна томографія (КТ), магнітно-резонансна томографія (МРТ) не є необхідністю в діагностиці ГП, але вони є фундаментальними інструменти для виявлення причин, ступеня тяжкості і ускладнень ГП. Оцінка ступеня тяжкості ГП насправді одне з найважливіших питань в лікуванні даного захворювання, оскільки ми можемо оцінити тяжкість стану хворого та спрогнозувати перебіг захворювання, використовуючи, наприклад, шкалу Бальтазар. Комп’ютерна томографія (КТ) є одним з найчутливіших методів дослідження (71-100%) при ГП і його ускладненнях, що дає різнобічну інформацію про стан ПЗ і заочеревинного простору, залучення в процес жовчовивідних шляхів. КТ з контрастуванням – це золотий стандарт обстеження пацієнтів з ГП, яким легко можна скористатися в ургентній ситуації, дозволяє з високою точністю діагностувати наявність панкреонекрозу, оцінити його масштаб і локалізацію, виявити різноманітні ангіогенні ускладнення. Діагностична цінність МРТ не менша, ніж в КТ, але діагностичний процес займає набагато більше часу, тому утруднює використання в невідкладній ситуації. Ускладнення гострого панкреатиту можна поділити на локалізовані та генералізовані. До локалізованих ускладнень можна віднести: гострі перипанкреатичні рідинні скупчення (ГПРС), гострі некротичні скупчення (ГНС), відмежовані некрози (walled-off necrosis), псевдокисти, тромбоз вен, псевдоаневризми та кровотечі. З генералізованих ускладнень можливі синдром поліорганної недостатності (СПОН) та сепсис. У цьому огляді ми зосередилися на КТ і МРТ-висновках місцевих ускладнень ГП, коли і як проводити КТ і МРТ. Ми також звернули увагу на останні розробки в діагностичній класифікації ускладнень ГП.
ФІЗИЧНА РЕАБІЛІТАЦІЯ ПРИ ГІПЕРАКТИВНОСТІ У ДІТЕЙ РІЗНОГО ВІКУ
Authors: Чурпій І. К. , Фіцич М. В.
Published: March 2019

Гіперактивність - це стан, при якому активність і збудливість дитини перевищує норму, процеси збудження переважають над процесами гальмування.

Найбільш явною ознакою гіперактивності є поведінкові проблеми. Це проявляється у надмірних, невпорядкованих та хаотичних фізичних рухах та різкою зміною поведінки.

Поведінкові особливості дітей з гіперактивністю зводяться в середньому в 70% випадків до появи занепокоєння, на що 50% припадає на неврологічні звички і у 20% - проблеми із сном.

У даній статті ми хочемо виділити дві найвираженіші ознаки гіперактивних дітей, а саме хаотичні рухи та дефіцит уваги і розкрити теоретичний і практичний їх взаємозв'язок із фізичною реабілітацією.

Практичне дослідження сучасного стану проблеми підтвердило необхідність пошуку ефективних реабілітаційних засобів, спрямованих на попередження, подолання чи відновлення порушених функцій і систем організму та корекцію вторинних недоліків у дітей з гіперактивністю різного віку.

Проведене реабілітаційне дослідження засвідчило високу ефективність проведеної комплексної фізичної реабілітаційної програми для дітей даної категорії на тлі покращення стану здоров’я та зростання всіх показників психофізичного розвитку, що досліджувалися і може бути рекомендована для використання у практиці.
PRACTICAL CLASSES WITH FOREIGN STUDENTS IN THE SURGICAL DEPARTMENT
Authors: Каратєєва С. Ю. , Плеш І. А. , Музика Н. Я. , Кшановська Г. І. , Антонів А. А.
Published: March 2019

Presenting methods of improving practical classes with foreign students. During the testing of students in practical classes on surgical disciplines, one can use the discussion of a clinical case, approval, preservation of students' own thoughts, discussion with the teacher, development and acquisition of practical skills; all these measures greatly improve the acquisition of material on this topic of classes.
ПОРІВНЯЛЬНИЙ АНАЛІЗ ВІДДАЛЕНИХ РЕЗУЛЬТАТІВ РІЗНИХ МЕТОДІВ ІНТЕРВЕНЦІЙНОГО ЛІКУВАННЯ ХВОРИХ З КІСТОЗНО-ЗМІНЕНИМИ ВУЗЛАМИ ЩИТОПОДІБНОЇ ЗАЛОЗИ
Authors: Коломійцев В. І. , Маріна В. Н. , Костюк О. В.
Published: March 2019

Метою дослідження було порівняння віддалених результатів якості життя пацієнтів із кістозно-зміненими вузлами щитоподібної залози після застосування різних методів інтервенційного лікування.

Проведено ретроспективний аналіз 189 пацієнтів, які лікувалися з приводу солітарних кістозно-змінених вузлів ЩЗ у період від 2003 до 2012 років. Порівнювали результати лікування 3-х груп: склеротерапія етанолом – 63 пацієнти; традиційна гемітироїдектомія – 65; модифікована гемітироїдектомія – 59 хворих. Вивчалась частота виникнення ускладнень, а також за допомогою універсального опитувальника MOS SF-36 визначали параметри якості життя пацієнтів у терміни 3 місяці, 1 рік та 5 років після інтервенцій.

Проведення склеротерапії етанолом супроводжувалось меншою кількістю скарг та ускладнень у порівнянні з операційним лікуванням у всіх періодах спостереження, а також вищими параметрами якості життя в сегменті фізичного здоров’я, у порівнянні з  традиційною гемітироїдектомією. Модифікована гемітироїдектомія демонструвала схожі результати в ранні терміни (3 місяці), проте у віддалених термінах (1 та 5 років) були виявлені вищі показники фізичного здоров’я порівняно із традиційною операцією. У віддалені після хірургічного лікування терміни до 26% пацієнтів потребує замінної терапії гормонами щитоподібної залози, у той же час після склеротерапії – 4%.
ОЦІНКА ІМУНОЛОГІЧНИХ ПОРУШЕНЬ У ХВОРИХ НА В-КЛІТИННУ ХРОНІЧНУ ЛІМФОЦИТАРНУ ЛЕЙКЕМІЮ
Authors: Курилів Г. М. , Дрогомерецька О. І. , Якубовська І. О.
Published: March 2019

Встановлено,  що у хворих на В-ХЛЛ до початку лікування за протоколом FC (флударабін, циклофосфамід) спостерігали достовірні нижчі рівні СD3+ , СD4+ ,  СD16+ , СD22+ клітин, імуноглобулінів, циркулюючих імунних комплексів та показників  фагоцитозу в порівнянні із особами контрольної групи.  На основі результатів проведеного дослідження встановлено позитивний імуномодулюючий вплив етіопатогенетичного лікування на рівні сироваткових імуноглобулінів, субпопуляцій лімфоцитів та показників фагоцитарної функції. Проте, наявність у  хворих частого інфекційного синдрому свідчить про те, що кількісні позитивні зміни показників імунограми не є достатніми для забезпечення належного імунного захисту організму від інфекцій, що може бути пов’язано із морфологічними змінами будови імуноглобулінів та структури імунних клітин. Тому вивчення структури імуноглобулінів і функціональної активності імунокомпетентних клітин є перспективним для подальших досліджень.
СУЧАСНІ ЗАСОБИ ДОГЛЯДУ ЗА РОТОВОЮ ПОРОЖНИНОЮ, ЖУВАЛЬНІ ГУМКИ. ПРАВИЛА ЇХНЬОГО ВИКОРИСТАННЯ
Authors: Мельничук Г. М. , Кушніренко М. О. , Кашівська Р. С. , Мельничук А. С. , Літинська О. В.
Published: March 2019

Резюме. На підставі здійсненого огляду літератури за 1999-2018 роки встановлено, що на ринку існує багато засобів для індивідуальної гігієни ротової порожнини. У статті описано їхні різновиди, зокрема, зубні порошки і пасти, ополіскувачі, гелі для ротової порожнини, жувальні гумки і палички, препарати пробіотичної ланки. Наведено класифікації сучасних засобів догляду за ротовою порожниною, з’ясовано та описано показання до їхнього застосування, вказано позитивні та негативні властивості. Зазначено, що додатковим елементом для очищення ротової порожнини можуть слугувати жувальні гумки. Описано переваги та недоліки жувальних гумок, правила їхнього застосування, наголошено на важливості дотримання цих правил.

Знання арсеналу засобів для гігієни ротової порожнини і правильний вибір їх забезпечить первинну профілактику карієсу і захворювань тканин пародонта та стійкі тривалі результати лікування цих хвороб (вторинну профілактику). Цей вибір відіграє важливу роль при складанні плану профілактики і лікування пацієнта, адже значна частина успіху залежить від індивідуального догляду за ротовою порожниною та від співпраці пацієнта з лікарем.
СТРЕС-ЛІМІТУЮЧІ МЕХАНІЗМИ АДАПТАЦІЇ ДО ІММОБІЛІЗАЦІЙНОГО СТРЕСУ ВИСОКОРЕЗИСТЕНТНИХ ДО ГІПОКСИЧНОЇ ГІПОКСІЇ САМЦІВ І САМИЦЬ ЩУРІВ
Authors: Ординський Ю. М. , Рябоконь М. О. , Болюх О. О. , Денефіль О. В.
Published: March 2019

Резюме. В основі розвитку багатьох хвороб лежить гіпоксія, зокрема кардіоваскулярної системи. Малорухомий спосіб життя також призводить до розвитку захворювань серцево-судинної системи. Для забезпечення адекватної адаптації до шкідливих факторів довкілля необхідна активація стрес-лімітуючих систем. До них відносять антиоксидантну, холінергічну системи.
A escola como ambiente obesogênico - as influências sobre a alimentação infantil, a partir da vulnerabilidade do consumidor
Authors: Pereira Cristiane Silva do Nascimento , Barros Denise Franca , Hemais Marcus Wilcox
Published: March 2019

Neste trabalho, buscou-se identificar quais são as principais influências que contribuem para o consumo infantil de alimentos obesogênicos nas escolas. Para isso, foram feitas 17 entrevistas em profundidade com diferentes agentes presentes nesse mercado, na cidade do Rio de Janeiro, que permitiram entender os mecanismos por trás de tais influências. Os sujeitos de pesquisa incluíram diretores de escolas, donos e administradores de cantinas escolares, pais, professores, publicitários e responsáveis pela Agência Nacional de Vigilância Sanitária e pelo Conselho Regional de Nutrição. A partir da análise dos dados, é possível compreender que a vulnerabilidade infantil é crescente no Brasil, em grande parte devido à existência de uma estrutura mercadológica impulsionada pelo sistema de marketing desenvolvido por grandes empresas, fazendo com que o consumo de alimentos obesogênicos cresça e, proporcionalmente, as organizações alimentícias.
The pecking order theory and life cycle: Evidence from French firms
Authors: Mabrouk Lamia , Boubaker Adel
Published: March 2019

Contrary to the trade-off theory, pecking order theory is based on the information asymmetry that exists between internal stakeholders (owners, managers) and external stakeholders (donors) to the company. We study firms’ financing behaviour over life cycle stages in the context of the pecking order theory. This paper is interested in testing the relation between ownership structure, the life cycle and the funding classification in French companies in the period 2005-2014. The hypotheses tested were derived from the pecking order models and analysis was conducted on data panel with econometric software Stata. The results show that the pecking order explains the debt in French companies that are in growth phase, maturity or decline.
Can a Hybrid Method Improve Equity Valuation? An Empirical Evaluation of the Ohlson and Johannesson (2016) Model
Authors: Gao Zhan , Myers James N. , Myers Linda A. , Wu Wan-Ting
Published: March 2019

This paper investigates the validity and usefulness of “hybrid” valuation models. We recast the model in Ohlson and Johannesson (2016) as a hybrid of the Dividend Discount Model and an earnings-based price multiple model, and develop a new hybrid model that generalizes the Residual Income Valuation Model. After validating the theoretical properties of these models' unique parameters, we assess the usefulness of the hybrid models in two applications. In application one, we find that intrinsic values from the hybrid models are more accurate than those from common discounted models or price multiple models. These improvements are attributable to the hybrid models' ability to incorporate stock price and more realistic assumptions about growth. In application two, we find that the implied cost of equity from the hybrid models better captures systematic risks and key idiosyncratic risks, and captures expected returns. These results demonstrate the validity and usefulness of hybrid valuation models.

JEL Classifications: G12; G14; G17; G31; M41.

Data Availability: The data used are publicly available from the sources cited in the text.
A PRODUÇÃO DA SUBJETIVIDADE A PARTIR DA ANÁLISE DO PERFIL PROFISSIONAL PRESENTE NA REVISTA HSM MANAGEMENT
Authors: Silva Rafael Bianchi , Dias Daniela Midori Taguchi
Published: March 2019

Este artigo analisa como o perfil de profissional de alto desempenho foi disseminado pela revista HSM Management a partir das publicações entre 1997 e 1999. Adotou-se o conceito de subjetividade a partir de autores como Gilles Deleuze, Felix Guattari e Suely Rolnik, além de valer da análise foucaultiana do discurso. Observou-se que através de diferentes artigos publicados, a revista buscou traçar um perfil de trabalhador para o mercado de trabalho do século XXI. Concluiu-se que, entre outras características, esse trabalhador deveria ser capaz suportar as exigências de um mercado de trabalho flexível além de deter a capacidade de avaliar-se continuamente.
Os Efeitos dos Estilos de Liderança e Vício em Internet no Tecnoestresse
Authors: Sousa Rogério Luciano de , Cappellozza Alexandre
Published: March 2019

As tecnologias de informação e comunicação trazem diversos benefícios para as organizações, mas podem gerar problemas com consequências ao profissional, inclusive, com o vício em internet. Por outro lado, os líderes organizacionais também podem influenciar o estresse percebido no trabalho pelos subordinados. Este estudo analisou os efeitos da liderança e do vício em internet sobre o estresse pelo uso excessivo das tecnologias, também chamado tecnoestresse. A partir dos dados de 379 trabalhadores, os resultados indicam que os estilos de liderança influenciam positivamente o tecnoestresse, e a liderança laissez-faire promove, com maior intensidade, tal dissabor ao trabalhador. Já os efeitos do vício em internet são variados nas formas estudadas dos relacionamentos dos estilos de liderança com o tecnoestresse.
TO THE QUESTION OF SALMON POPULATION REPLENISHMENT ON THE EXAMPLE OF BLACK SEA TROUT (SALMO TRUTTA LABRAX PALLAS, 1814)
Authors: Karalyute Elena Algimantovna , Lagutkina Lina Yurievna , Chervonenko Elena Mikhaylovna
Published: March 2019

The article highlights the future development of salmon cultivation at the example of breeding bull-trout ( Salmo trutta labrax Pallas, 1814) inhabiting the Black Sea and Azov Sea. There has been made the analysis of key biotechnical processes of forming brood stock and reproduction of bull-trout in order to replenish the endangered fish population. The deficiency of producers, low abundance of the brood stock and, actually, a low number of bull-trout population (bull-trout is listed into the Red Book of the Krasnodar region and the Red Book of the Russian Federation) are the main limiting factors of the species reproduction. There has been given the review of the current state of species reproduction, as well as the analysis of the trout-breeding plant “Adler” efforts on reproduction and preservation of bull-trout population. In order to produce viable breed for further releasing into the natural habitat and replenishing population of this valuable species, as well as due to low ability to survive (13%) there have been given recommendations on using live feed such as gill-footed crustaceans Artemia salina along with artificial feed. The work on reproducing and forming the brood stock should become the main objective of the trout hatchery “Adler” over the medium term.
Osmanlı Medreselerini Islah Çabaları Üzerine Bir Değerlendirme
Authors: YILDIZ Hasan
Published: March 2019

Osmanlı eğitim sisteminin zeminini oluşturan medreseler altı asra

yaklaşan kurumsal ömrü sürecinde devlete ve topluma önemli hizmetlerde bulunmuş

müesseselerdir.  Devlet teşkilatının ve

imparatorluğun asli unsuru olan Müslüman ahalinin ihtiyaçları esas alınarak

kurulan ve yaygınlaştırılan medreselerde zaman zaman ortaya çıkan olumsuzluklar

ve düzensiz uygulamalar nedeniyle ıslahat faaliyetlerinin gerçekleştirilmiş

olması olağan bir durumdur. Islahat faaliyetlerinin gerekçesi olan kural dışı uygulamaları

ve olumsuzlukları medreselerdeki bozulmanın ve gerilemenin başlangıcı kabul

ederek bunu üç asır boyunca devam ettiren akademik çalışmaların çokluğu dikkat

çekmektedir.  Bozulmayı ya da gerilmeyi

tarihte yaşanmış bir olaya bağlamak, altı asırlık müktesebatı bağlamından

kopararak parçacı bir bakış açısıyla ele almak, ayrıca mukayese ve

değerlendirmeleri eşdeğer olmayan eğitim kurumları üzerinden gerçekleştirmek

sağlıklı sonuçlara ulaşmayı engelleyen yaklaşımlardır.

Bu

makalede altı asırlık kurumsal geçmişe sahip olan Osmanlı medreselerinde ıslahata

duyulan ihtiyaç, ıslah çabaları ve sonuçları, bozulma ve gerilemenin yapısal

bir sorundan kaynaklanıp kaynaklanmadığı, uygulayıcıların icraatlarının

bozulmaya ve gerilemeye etkisinin hangi düzeyde olduğu hususları ele alınıp

değerlendirilecektir.       
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes
Authors: Savchenko Liudmyla G. , Digtiar Nataliia I. , Selikhova Liudmyla G. , Kaidasheva Elvira I. , Shlykova Oksana A. , Vesnina Liudmyla E. , Kaidashev Igor P.
Published: March 2019

Introduction. Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers.

L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin 1(SIRT1). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications. The aim of this study was to investigate L effects directed on the pro-inflammatory NF-kB pathway and expression of SIRT1 in obese patients with type 2 diabetes mellitus (DM).

Materials and Methods. 15 obese patients with type 2 diabetes were studied, all using metformin (1-2 g/day) and sulfonylurea (glimiperide). All patients received L 1.2 mg daily add-on to stable therapy for 6 weeks. Blood samples were collected before, 6 weeks after start of treatment and after an overnight fast 6 weeks after stopping L, mononuclear cells (MNC) were isolated. The mRNA expressions of TNF-α, TLR2, TLR4, NOD1, IL-2 and SIRT1 were measured in MNC by RT-PCR. Ceruloplasmin concentration was measured in plasma by photometric method.

Results. In this add-on pilot clinical investigation we received new data that L can inhibit proinflammatory NF-kB pathway by increased SIRT1 expression in obese patients with type 2 DM improving metabolic profile. The mRNA expression in MNC of TNF-α, IkB, TLR2, TLR4, and plasma ceruloplasmin fell after 6 weeks of L. Expressions of IL-2 and NOD-1 were stable. There was a significant increase of SIRT1 mRNA expression. The mRNA expression in MNC of TNF-α, IkB, TLR2, TLR4, NOD1, SIRT1 and ceruloplasmin concentrations did not reverse to baseline levels after 6 weeks stopping of L treatment. IL-2 expression decreased in comparison with basic level.

Conclusions. L has a potent anti-inflammatory effect as do GLP-1 agonists due to inhibition of NF-kB pathways and up-regulate SIRT1 expression, down-regulating pro-inflammatory factors including cytokines (TNF-α), extra- and intracellular receptors (TLR2, TLR4), and inflammation markers such as ceruloplasmin. Long lasting effects of L can be mediated by epigenetic regulation of NF-kB pathway by SIRT-1.
Các yếu tố ảnh hưởng đến ý định vay tiêu dùng của sinh viên trên địa bàn Hà Nội
Authors: Nguyen Mai
Published: March 2019

Nghiên cứu này thực hiện nhằm khám phá và kiểm chứng các yếu tố tác động đến ý định vay tiêu dùng của sinh viên trong bối cảnh thị trường tài chính tiêu dùng đang phát triển rất sôi động trong những năm gần đây. Dựa trên kết quả phân tích số liệu khảo sát 225 sinh viên trên địa bàn Hà Nội, nghiên cứu đã cho thấy, thái độ và ảnh hưởng của người thân là hai yếu tố cơ bản ảnh hưởng đến ý định vay tiêu dùng của sinh viên, trong đó thái độ là yếu tố chủ chốt. Trong khi đó, thái độ lại được quyết định bởi nhận thức sự hữu ích và nhận thức sự tiện dụng đối với việc vay tiêu dùng với các biến số thể hiện đặc điểm của sản phẩm vay tiêu dùng như lãi suất, thời gian hoàn trả khoản vay, chương trình ưu đãi, thông tin khoản vay rõ ràng minh bạch, thời gian xử lý hồ sơ nhanh chóng. Ngoài ra, nghiên cứu này cũng cho thấy sinh viên sẽ sẵn sàng đi vay nếu cần thiết. Điều này thể hiện thái độ cởi mở của nhóm khách hàng trẻ và là tín hiệu tốt cho sự phát triển của thị trường tín dụng tiêu dùng tại Việt Nam trong những năm tới. Vì vậy, một số hàm ý đối với các tổ chức tín dụng tiêu dùng cũng đã được nêu ra trong bài viết.
Some growth parameters of Chondrostoma regium (Heckel, 1843) inhabiting Karasu River (East Anatolia, Turkey)
Authors: SERDAR Osman , ÖZCAN Ebru İfakat
Published: March 2019

The present study was carried out in order to determine age and some growth parameters of brond snout (Chondrostoma regium (Heckel, 1843)) caught in 14 different stations from Karasu River (East Anatolia, Turkey).  For this purpose, a total of 236 fish specimen (124 females and 112 males) of C. regium were captured between 2014 and 2016 by electroshocker.  Total length and weight of C. regium ranged from 11.0 to 33.0 cm, 33.0 to 324.0 g, respectively.  Female:male ratio was estimated as 1:0.903 and the age groups of C. regium were 1-7.  The parameters of von Bertalanffy growth parameter estimated as Lt=40.17[1-e-0.154(t+2.14)]; Wt=495.009[1-e-0.154(t+2.14)]2.50 for combined sexes and the growth performance index (Ф') value was calculated as 2.395.  The length and weight relationships were as follows: W=0.0503L2.50 (R² = 0.97; confidence intervals of b=2.41-2.70; p<0.001).  The growth type was negative allometric.
Effectiveness of Prostatic Capsular Artery Resistive İndex in the Evaluation of Benign Prostatic Hyperplasia Treatment
Authors: TURGUT Bekir , HAMARAT Mustafa Bilal
Published: March 2019

We aimed to evaluate whether the
prostatic capsular artery resistive index can be a parametric criterion in
evaluating the efficacy of α-blocker treatment and the severity of the disease
in patients with benign prostatic hyperplasia. The clinical and diagnostic
investigation findings and the radiographic images were recorded during the
treatment and during the application of procedures in the patients who
presented to our hospital with lower urinary system symptoms. Then, these data
and the information of the respective patients recorded in the hospital
database were examined retrospectively. A total of 66 patients were included in
the study. Of the patients, 36 with higher IPSS were recommended to be treated
and had a mean resistive index of 0.68±0.09, and the patients with lower IPSS
had a mean resistive index of 0.65±0.05. The difference between these two
values was found to be statistically significant (p<0.05).  In 36 patients who were treated for lower
urinary system symptoms, the mean resistive index before the treatment was
0.68±0.09. After the treatment, the mean resistive index decreased to
0.64±0.07. This decrease was statistically significant (p<0.05). The mean
IPSS was 20.38±4.03 before the treatment and it decreased to 14.38±3.69  after the treatment, showing a statistically
significant difference, similarly (p<0.05). We are of the opinion that the
resistive index of the posterior capsular artery of the prostate gland is a
parametric indicator to determine the severity of the benign prostatic
hyperplasia and to assess the efficacy of the treatment with alpha-blocker
medications.
COMPRENSIÓN DE TEXTOS E INTELIGENCIA EMOCIONAL EN LOS ESTUDIANTES UNIVERSITARIOS DE HUANCAYO
Authors: Palacios Villanes Marco Antonio , Cañari Contreras Miriam Dacia
Published: March 2019

La interrogante a responder fue ¿Cuál es la relación que existe entre la comprensión de textos y la inteligencia emocional en los estudiantes universitarios de Huancayo? El objetivo central ha sido: Determinar la relación que existe entre la comprensión de textos y la inteligencia emocional en los estudiantes universitarios de Huancayo. Se tuvo como hipótesis general: la relación que existe entre la comprensión de textos y la inteligencia emocional en los estudiantes universitarios de Huancayo, es directa y significativa. Investigación cuantitativa, transversal, correlacional. Muestra no probabilístico e intencionado, constituido por 385 estudiantes, agrupados por género, edad, condición económica, condición familiar y grado de instrucción de los padres. La prueba pedagógica sirvió para medir la comprensión de textos y el inventario de inteligencia emocional, para la inteligencia emocional. Los resultados evidencian correlación directa, no significativa de nivel bajo y débil entre la comprensión de textos y la inteligencia emocional en los estudiantes universitarios de Huancayo.
EL PORTAFOLIO RECURSO DIDÁCTICO PARA MEJORAR LAS ACTITUDES HACIA LA INVESTIGACIÓN EN ESTUDIANTES UNIVERSITARIOS
Authors: Palomino León Juan de Dios Adalberto
Published: March 2019

La presente investigación partió del problema: ¿El uso del portafolio como recurso didáctico mejora las actitudes de los estudiantes hacia la investigación en la Carrera de Educación de la Universidad Nacional del Centro del Perú? considerando las dimensiones: afectiva, cognitiva y conductual. La hipótesis fue que el uso del portafolio como recurso didáctico mejora las actitudes de los estudiantes hacia la investigación en la Carrera de Educación de la Universidad Nacional del Centro del Perú, considerando sus dimensiones. Para verificarla experimentalmente se aplicó el diseño cuasi experimental, con dos grupos, pre y post prueba, siendo el reactivo el portafolio como recurso didáctico. Luego del procesamiento de datos, se confirmó la hipótesis general, encontrándose efectos favorables en las dimensiones afectiva y conductual, pero no en la cognitiva.
The use of radial basis function and non-linear autoregressive exogenous neural networks to forecast multi-step ahead of time flood water level
Authors: Faruq Amrul , Abdullah Shahrum Shah , Marto Aminaton , Abu Bakar Mohd Anuar , Mohd Hussein Shamsul Faisal , Che Razali Che Munira
Published: March 2019

Many different Artificial Neural Networks (ANN) models of flood have been developed for forecast updating. However, the model performance, and error prediction in which forecast outputs are adjusted directly based on models calibrated to the time series of differences between observed and forecast values, are very interesting and challenging task. This paper presents an improved lead time flood forecasting using Non-linear Auto Regressive Exogenous Neural Network (NARXNN), which shows better performance in term of forecast precision and produces minimum error compared to neural network method using Radial Basis Function (RBF) in examined 12-hour ahead of time. First, RBF forecasting model was employed to predict the flood water level of Kelantan River at Kuala Krai, Kelantan, Malaysia. The model is tested for 1-hour and 7-hour ahead of time water level at flood location. The same analysis has also been taken by NARXNN method. Then, a non-linear neural network model with exogenous input promoted with enhancing a forecast lead time to 12-hour. Both about the performance comparison has briefly been analyzed. The result verified the precision of error prediction of the presented flood forecasting model.
A influência de fatores socioculturais nas atitudes face à homossexualidade: Estudo comparativo
Authors: Gomes Mara Mendonça , Assunção Sandra , Azevedo Solange , Teixeira Carla M.
Published: March 2019

A forma como a sociedade vê a homossexualidade sofreu alterações ao longo do tempo, sendo o objetivo deste estudo perceber de que forma é vista a homossexualidade na atualidade, tendo por base diferentes variáveis: sexo, meio (rural/urbano), idade, religiosidade, contacto interpessoal LGBT, habilitações académicas e o setor profissional. Este estudo foi do tipo quasi-experimental e de caráter transversal. A amostra foi de 192 indivíduos, 97 mulheres e 95 homens. Aplicou-se um questionário sociodemográfico e uma Escala Multidimensional de Atitudes Face a Lésbicas e Gays (EMAFLG). Os resultados evidenciaram valores mais elevados nas subescalas negativas e mais baixos na subescala positiva relativas à perceção da homossexualidade concluindo que os homens, os indivíduos que passaram a maior parte da sua vida em meio rural, as pessoas com mais idade, os indivíduos que se consideram religiosos, aqueles que não possuem contacto com LGBT, os que possuem habilitações académicas mais baixas e por fim os indivíduos que trabalham numa área do setor secundário são mais homofóbicos. Concluiu-se que existe preconceito relativamente à homossexualidade.
Avaliação de tratamento da fobia de cães a fogos de artifício utilizando roupa artesanal
Authors: Rocha Leandro Branco , Souza Dias Jéssica , Oliveira Rocha Monique Francielle , Silva Farias Priscilla , Luísa Ruschel Marina , Rangel de Sá Marina Andrade , Alberto Tudury Eduardo
Published: March 2019

Comportamentos indesejados associados a fobia de fogos ocorrem com frequência em cães. O objetivo deste estudo foi avaliar a eficácia da utilização de roupa artesanal em cães com o intuito de reduzir estes comportamentos. Através de entrevistas na comunidade, um total de 49 cães apresentaram sinais de fobia e foram inclusos no estudo. Roupas artesanais confeccionadas a partir de camisas de algodão dos tutores foram padronizadas de forma que promovessem leve pressão nos cães. O levantamento de dados foi dividido em duas etapas, uma buscando a opinião do tutor e a outra dos pesquisadores sobre o efeito da roupa. No decorrer da primeira etapa, houve 28 desistências (57,14%), correspondentes a cães que não aceitaram a permanência da roupa. Dos 21 cães que aceitaram a utilização da roupa, foi observado diminuição dos comportamentos indesejados característica de fobia a fogos em 76,19% e 100% dos cães através das avaliações dos tutores e pesquisadores respectivamente. A roupa fabricada artesanalmente, pode ser útil em diminuir os comportamentos característicos de fobia a fogos de artifício em cães.
MENINGKATKAN PEMAHAMAN RESIKO PERILAKU SEKSUAL PRA NIKAH MELALUI LAYANAN INFORMASI DENGAN MEDIA AUDIO VISUAL SISWA SMA NEGERI 2 MEMPAWAH
Authors: Hendrik Hendrik , Ratini Ratini
Published: March 2019

Tujuan penelitian ini adalah 1) mengetahui pemahaman resiko perilaku seksual pra nikah sebelum diberikan layanan informasi dengan media audio visual siswa SMA Negeri 2 Mempawah, 2) mengetahui pelaksanaan layanan informasi dengan media audio visual meningkatkan pemahaman resiko perilaku seksual pra nikah siswa SMA Negeri 2 Mempawah, 3) peningkatan pemahaman resiko perilaku seksual pra nikah melalui layanan informasi dengan media audio visual siswa SMA Negeri 2 Mempawah. Metode penelitian ini adalah penelitian tindakan Bimbingan dan Konseling. Subjek uji coba terbatas terdiri dari 33 siswa. Hasil penelitian menunjukkan bahwa pemahaman resiko perilaku seksual pra nikah melalui layanan informasi dengan media audio visual siswa SMA Negeri 2 Mempawah meningkatkan pemahaman resiko perilaku seksual pra nikah, melalui 4 tahapan dalam penelitian tindakan bimbingan dan konseling, yaitu: 1) perencanaan, 2) pelaksanaan, 3) pengamatan, dan 4) refleksi. Berdasarkan hasil penelitian menunjukkan terdapat peningkatan skor awal 57% mengalami peningkatan setelah dilaksanakan tindakan siklus I menjadi 65% dan  dilaksanakan tindakan siklus II meningkat lagi dengan persentase 77%. Dari peningkatan hasil penelitian di atas disarankan guru bimbingan dan konseling dapat menggunakan layanan informasi dengan media audio visual untuk meningkatkan pemahaman resiko perilaku seksual pra nikah.
PENERAPAN ASAS AMAN DAN TERBUKA TERHADAP PROSES PENDAFTARAN TANAH
Authors: - Anhar
Published: March 2019

Registration system of land in Indonesia adheres to the system negative berunsur positive. based system used it has the weaknesses. to reduce the risk of the use of the system is then in the government regulation No. 24 1997 on the land registry applied principle safe and open in the land registry. although the principle that has been applied but still there are problems regarding the certificate of land rights are published. in Indonesia is still a lot of certificate issued a lot of problems and sued in court. especially in the district Lombok Western, in the area sekotong there land 100 acres of certified double contested entrepreneur Bali and Jakarta.
PENERAPAN ASAS SEDERHANA DAN TERJANGKAU DALAM PROSES PENDAFTARAN HAK ATAS TANAH SECARA SPORADIK DI KABUPATEN LOMBOK BARAT
Authors: - Zaelani
Published: March 2019

Government regulation No. 24 1997 on the land registry, in section 2 mentioned that the land registry implemented bersasarkan some of the principle of which the principle of simple and affordable. principle simple intended to the provisions of anyway and procedure can easily be conceived by the parties concerned, especially the holder of land rights. then the principle of affordable intended affordability for parties that require especially with regard needs and the ability of class of economic weak. in particular the people in the district Lombok Western, the implementation of the principle that has not been in accordance with what to expect. in peroses registration land rights through sporadic still takes a long time and cost expensive.