bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Effectiveness and Study on Long-Term Mechanism of Sports World Campus App in Monitoring Extracurricular Physical Exercise of College Students
Authors: Meng Liang , Li Jianmin
Published: October 2021

The data of extracurricular physical exercise of college students before, at the time of, and after being monitored were compared and analyzed by the Sports World Campus app (a running app), and it was concluded as follows: (1) compared with the data before being monitored, the average number of running times per week and the proportion of physical education population increased significantly during and after being monitored; (2) compared with the data at the time of being monitored, the average number of running times per week and the proportion of physical education population decreased significantly after being monitored; and (3) per academic year, the average number of running times per week and the time of running increased year by year in the three years of being monitored. To derive a long-term mechanism, it is necessary to (1) raise the attention of school authorities, strengthen the supervision in management, and formulate a reasonable reward and punishment system; (2) optimize the quality of running apps to improve students’ sense of running experience; (3) set a reasonable amount of tasks per semester to guide students to conduct extracurricular physical exercise scientifically; and (4) promote students’ overall development, establish a culture of extracurricular physical activities, and cultivate students’ lifelong sports awareness.
Experimental Study on Alleviating Sports Injury through Data Screening of Functional Motor Biological Images
Authors: Rao Fan
Published: October 2021

In order to better reduce sports injury, a method based on functional motion biological image data is proposed. Through performing functional motion screening test on wushu athletes, including 7 items of test, each athlete is given a score according to the test standard. This paper summarizes the mistakes and deficiencies of common movement patterns of athletes and makes different intervention plans to improve the effect of sports injury screening. The results show that, at

P
>
0.001

, there was a significant difference, and the experimental group FMS total score (15.02 ± 3.7) was lower than the control group FMS total score (18.51 ± 1.45). The recognition rate of the system is higher than that of the system based on single feature, and the recognition performance is better than that of the standard SVM and KNN recognition methods. It is proved that the design of the system is feasible, reliable, and effective.
Automatic Parking Path Planning Based on Ant Colony Optimization and the Grid Method
Authors: Han Guo Liang
Published: October 2021

This paper analyzes the path planning problem in the automatic parking process, and studies a path planning method for automatic parking. The grid method and the ant colony optimization are combined to find the shortest path from the parking start point to the end point. The grid method is used to model the parking environment to simulate the actual parking space of automatic parking; then this paper makes some improvements to the basic ant colony optimization, finds the destination by setting the ants’ movement rules in the grid, and finds the shortest path after N iterations; since the optimal path found is a polyline, it will increase the difficulty of controlling vehicle path tracking and affect the accuracy of vehicle path tracking. The bezier curve is used to generate a smooth path suitable for vehicle walking. Finally, through matlab simulation, the obstacles in the environment are simulated, and the parking trajectory is obtained. The results show that the path planning method proposed in this paper is feasible.
Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels
Authors: Dietz Robert M. , Orfila James E. , Chalmers Nicholas , Minjarez Crystal , Vigil Jose , Deng Guying , Quillinan Nidia , Herson Paco S.
Published: October 2021

Hippocampal cell death and cognitive dysfunction are common following global cerebral ischemia across all ages, including children. Most research has focused on preventing neuronal death. Restoration of neuronal function after cell death is an alternative approach (neurorestoration). We previously identified transient receptor potential M2 (TRPM2) ion channels as a potential target for acute neuroprotection and delayed neurorestoration in an adult CA/CPR mouse model. Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) in juvenile (p20-25) mice was used to investigate the role of ion TRPM2 channels in neuroprotection and ischemia-induced synaptic dysfunction in the developing brain. Our novel TRPM2 inhibitor, tatM2NX, did not confer protection against CA1 pyramidal cell death but attenuated synaptic plasticity (long-term plasticity (LTP)) deficits in both sexes. Further, in vivo administration of tatM2NX two weeks after CA/CPR reduced LTP impairments and restored memory function. These data provide evidence that pharmacological synaptic restoration of the surviving hippocampal network can occur independent of neuroprotection via inhibition of TRPM2 channels, providing a novel strategy to improve cognitive recovery in children following cerebral ischemia. Importantly, these data underscore the importance of age-appropriate models in disease research.
Evolutionary Framework with Bidirectional Long Short-Term Memory Network for Stock Price Prediction
Authors: Zheng Hongying , Wang Hongyu , Chen Jianyong
Published: October 2021

As an important part of the social economy, stock market plays an important role in economic development, and accurate prediction of stock price is important as it can lower the risk of investment decision-making. However, the task of predicting future stock price is very difficult. This difficulty arises from stocks with nonstationary behavior and without any explicit form. In this paper, we propose a novel bidirectional Long Short-Term Memory Network (BiLSTM) framework called evolutionary BiLSTM (EBiLSTM) for the prediction of stock price. In the framework, three independent BiLSTMs correspond to different objective functions and act as mutation individuals, then their respective losses for evolution are calculated, and finally, the optimal objective function is identified by the minimum of loss. Since BiLSTM is effective in the prediction of time series and the evolutionary framework can get an optimal solution for multiple objectives, their combination well adapts to the nonstationary behavior of stock prices. Experiments on several stock market indexes demonstrate that EBiLSTM can achieve better prediction performance than others without the evolutionary operator.
Intelligent Intrusion Detection Based on Federated Learning for Edge-Assisted Internet of Things
Authors: Man Dapeng , Zeng Fanyi , Yang Wu , Yu Miao , Lv Jiguang , Wang Yijing
Published: October 2021

As an innovative strategy, edge computing has been considered a viable option to address the limitations of cloud computing in supporting the Internet-of-Things applications. However, due to the instability of the network and the increase of the attack surfaces, the security in edge-assisted IoT needs to be better guaranteed. In this paper, we propose an intelligent intrusion detection mechanism, FedACNN, which completes the intrusion detection task by assisting the deep learning model CNN through the federated learning mechanism. In order to alleviate the communication delay limit of federal learning, we innovatively integrate the attention mechanism, and the FedACNN can achieve ideal accuracy with a 50% reduction of communication rounds.
Prevalence and Distribution of Nonsyndromic Dental Anomalies in Children in Eastern Saudi Arabia: A Radiographic Study
Authors: Bakhurji Eman A. , Aldossary Fatima , Aljarbo Jood , AlMuhammadi Fatimah , Alghamdi Maysaa , Nazir Muhammad Ashraf
Published: October 2021

Objectives. To report the prevalence and distribution of nonsyndromic dental anomalies in children in eastern Saudi Arabia. Methods. This retrospective records review study involved radiographic examination of 6–18 years old pediatric patients who attended the Dental Hospital of the College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. Four calibrated examiners recorded nonsyndromic dental anomalies from patients’ digital orthopantomograms (OPG). The anomalies recorded were related to tooth number, shape, and location. Descriptive statistics, chi-square test, and Fisher exact tests were used to report prevalence and differences by gender, nationality, and medical history at the 5% significance level. Results. Of 2226 reviewed patients’ records, 1897 met the inclusion criteria and were included in the study. The study sample had equal distribution of males (52.6%) and females (47.4%) and comprised 81.2% Saudi children with a mean age of 8.8 ± 1.84 years. Most study subjects (97.8%) were in mixed dentition and 88.7% were healthy. The prevalence of dental anomalies was as follows: teeth rotations (24.5%), ectopically erupted teeth (6%), congenitally missing permanent teeth (5.4%), peg lateral (1.1%), supernumerary (0.5%), gemination (0.3%), and fusion (0.1%). No statistically significant differences were found in the distribution of dental anomalies by patients’ gender, medical history, and nationality (

p

value ≥0.05). Conclusion. This study showed that teeth rotations were the most common dental anomalies followed by ectopic eruptions and congenitally missing teeth. The study findings may guide dental practitioners to better diagnose and manage children with dental anomalies in eastern Saudi Arabia.
[Retracted] Protective Mechanism of Trimetazidine in Myocardial Cells in Myocardial Infarction Rats through ERK Signaling Pathway
Authors: Wu Zhenjun , Yu Lihua , Li Xinyue , Li Xuewen
Published: October 2021

Objective. To study the protective effect of trimetazidine on myocardial cells in rats with myocardial infarction and explore its effect on ERK signaling pathway. Methods. 40 SD rats were randomly divided into the sham operation group, model group, low‐dose group, and high‐dose group (intra‐abdominal injection of trimetazidine 5 mg/kg and 10 mg/kg, respectively), construction of rat myocardial infarction model by coronary artery left anterior descending artery ligation. 7 days after surgery, the survival rate and cardiac function of each group of rats were recorded. The myocardial infarct size was detected by TTC staining. The apoptosis level of rat cardiomyocytes was detected by TUNEL staining. The content of ROS in rat cardiomyocytes was detected by DCFH‐DA. Western‐blot was used to detection of Caspase‐3, Bcl‐2/Bax, and ERK signaling pathway‐related proteins in myocardial tissue. Results. Compared with the model group, the survival rate of the rats in the low‐dose group and the high‐dose group was significantly increased (P < 0.01), the cardiac function was significantly improved (P < 0.01), the myocardial infarct size was significantly decreased (P < 0.01), the level of apoptosis was significantly decreased (P < 0.01), the content of ROS in cardiomyocytes was significantly decreased (P < 0.01), the protein expression of Caspase‐3 and NF‐κB in cardiomyocytes was significantly decreased (P < 0.01), and the expression of Bcl‐2/Bax and p‐ERK were significantly increased (P < 0.01). Conclusion. Trimetazidine can activate ERK signaling pathway in cardiomyocytes of rats with myocardial infarction, increase the expression of p‐ERK, decrease the content of ROS in cardiomyocytes, decrease the expression of apoptotic proteins, reduce myocardial infarct size, improve cardiac function, and increase myocardial function.
Palmitic Acid Methyl Ester Enhances Adipogenic Differentiation in Rat Adipose Tissue-Derived Mesenchymal Stem Cells through a G Protein-Coupled Receptor-Mediated Pathway
Authors: Lin Jian-Hong , Chang Huan-Hsin , Lee Wen-Sen , Ting Pei-Ching , Luo Yu-Po , Yang Kun-Ta
Published: October 2021

Adipogenic differentiation from stem cells has become a research target due to the increasing interest in obesity. It has been indicated that adipocytes can secrete palmitic acid methyl ester (PAME), which is able to regulate stem cell proliferation. However, the effects of PAME on adipogenic differentiation in stem cell remain unclear. Here, we present that the adipogenic differentiation medium supplemented with PAME induced the differentiation of rat adipose tissue-derived mesenchymal stem cells (rAD-MSCs) into adipocyte. rAD-MSCs were treated with PAME for 12 days and then subjected to various analyses. The results from the present study show that PAME significantly increased the levels of adipogenic differentiation markers, PPARγ and Gpd1, and enhanced adipogenic differentiation in rAD-MSCs. Furthermore, the level of GPR40/120 protein increased during induction of adipocyte differentiation in rAD-MSCs. Cotreatment with PAME and a GPR40/120 antagonist together inhibited the PAME-enhanced adipogenic differentiation. Moreover, PAME significantly increased phosphorylation of extracellular signal-regulated kinases (ERK), but not AKT and mTOR. Cotreatment with PAME and a GPR40/120 antagonist together inhibited the PAME-enhanced ERK phosphorylation and adipogenic differentiation. PAME also increased the intracellular Ca2+ levels. Cotreatment with PAME and a Ca2+ chelator or a phospholipase C (PLC) inhibitor prevented the PAME-enhanced ERK phosphorylation and adipogenic differentiation. Our data suggest that PAME activated the GPR40/120/PLC-mediated pathway, which in turn increased the intracellular Ca2+ levels, thereby activating the ERK, and eventually enhanced adipogenic differentiation in rAD-MSCs. The findings from the present study might help get insight into the physiological roles and molecular mechanism of PAME in regulating stem cell differentiation.
MICAL2 Contributes to Gastric Cancer Cell Proliferation by Promoting YAP Dephosphorylation and Nuclear Translocation
Authors: Qi Chenxiang , Min Pengxiang , Wang Qianwen , Wang Yueyuan , Song Yixuan , Zhang Yujie , Bibi Maria , Du Jun
Published: October 2021

Dynamic cytoskeletal rearrangements underlie the changes that occur during cell division in proliferating cells. MICAL2 has been reported to possess reactive oxygen species‐ (ROS‐) generating properties and act as an important regulator of cytoskeletal dynamics. However, whether it plays a role in gastric cancer cell proliferation is not known. In the present study, we found that MICAL2 was highly expressed in gastric cancer tissues, and this high expression level was associated with carcinogenesis and poor overall survival in gastric cancer patients. The knockdown of MICAL2 led to cell cycle arrest in the S phase and attenuated cell proliferation. Concomitant with S‐phase arrest, a decrease in CDK6 and cyclin D protein levels was observed. Furthermore, MICAL2 knockdown attenuated intracellular ROS generation, while MICAL2 overexpression led to a decrease in the p‐YAP/YAP ratio and promoted YAP nuclear localization and cell proliferation, effects that were reversed by pretreatment with the ROS scavenger N‐acetyl‐L‐cysteine (NAC) and SOD‐mimetic drug tempol. We further found that MICAL2 induced Cdc42 activation, and activated Cdc42 mediated the effect of MICAL2 on YAP dephosphorylation and nuclear translocation. Collectively, our results showed that MICAL2 has a promotive effect on gastric cancer cell proliferation through ROS generation and Cdc42 activation, both of which independently contribute to YAP dephosphorylation and its nuclear translocation.
Potential Influential Factors of In‐Hospital Myocardial Reinfarction in ST‐Segment Elevation Myocardial Infarction (STEMI) Patients: Finding from the Improving Care for Cardiovascular Disease in China‐ (CCC‐) Acute Coronary Syndrome (ACS) Project
Authors: Cai Xiaojie , Zhou Juan , Li Wenyuan , Cheng Lele , Yuan Zuyi , Xiao Yihui
Published: October 2021

In this study, 39915 inpatients with a discharge diagnosis of STEMI from the CCC‐ACS project phase I and II were included. The prevalence of the medical history, clinical complications on admission and treatment during hospitalization in the STEMI inpatients with and without in‐hospital reinfarction was presented. The factors that were differentially distributed and of critical clinical significance (e.g., age, sex, heart rate, smoking, MI history, HF history, COPD history, stroke, hypertension, diabetes, PCI treatment, administration of DAPT, and statins) were entered into standard Cox regression model and competing risk model for potential influential factors of in‐hospital reinfarction. Patients with a higher heart rate (OR 1.018; 95% CI 1.003 to 1.033) were more susceptible to in‐hospital reinfarction. Myocardial infarction history (OR 2.840; 95% CI 1.160 to 6.955) was a risk factor of in‐hospital reinfarction independent of hypertension, diabetes, and dyslipidaemia.
Study on Direct Writing of Gallium Metal for the Flexible Sensor
Authors: Liu Junfeng , Ma Haopeng , Yang Yong , Yang Weimin , Jiao Zhiwei , Yu Yuan
Published: October 2021

There is an urgent need for a simple and effective method to manufacture flexible sensors composed of liquid metal. Gallium (Ga) metal has become an ideal flexible conductive material due to its high conductivity, low melting point, and high flow characteristics. In this paper, liquid Ga metal is directly written on the polyvinyl alcohol (PVA) film through the driving mode of piston extrusion; then, the Ga metal wire is transferred and sealed with silica gel. The advantages of piston mode are studied, and the direct writing parameters of the liquid Ga metal, including extrusion speed, nozzle height, printing speed, and nozzle inner diameter, are systematically optimized. The flexible sensor based on the sealed liquid Ga metal has good resilience under the external load. This work provides a specific reference for direct writing of liquid Ga metal and its sealing technology for the flexible sensor.
Effect of Abdominal Massage with and without Salvia officinalis on Nausea and Vomiting in Patients with Cancer Undergoing Chemotherapy: A Randomized Clinical Trial
Authors: Rafiee Sarbijan Nasab Farshid , Mangolian Shahrbabaki Parvin , Dehghan Mahlagha , Tajadini Haleh , Baniasadi Hamideh , Sabzevari Sakineh
Published: October 2021

Objective. The aim of this study was to determine the effect of abdominal massage with and without Salvia officinalis on nausea and vomiting in patients with cancer undergoing chemotherapy. Methods. In this randomized clinical trial, 60 patients undergoing chemotherapy were placed in one of two intervention groups or in a control group. Abdominal massage with and without Salvia officinalis was performed for 15 minutes twice a day for 3 consecutive days by the patient’s companion. The rate of nausea and vomiting was measured with a Visual Analog Scale. Results. Findings showed that immediately after the intervention, the mean score of nausea in abdominal massage with Salvia officinalis group was lower than that of the control group. The mean score of nausea was not different between abdominal massage and control groups. One week after the intervention, the mean score of nausea was not different among the three groups. In addition, the frequency of vomiting was not different among the three groups. Conclusion. Abdominal massage with/without Salvia officinalis as a complementary medicine has not considerable effect on reducing nausea and vomiting in patient with cancer undergoing chemotherapy. More studies are needed to achieve better and more accurate results.
The Efficacy and Safety of Different Dosages of Rituximab for Adults with Immune Thrombocytopenia: A Systematic Review and Meta‐Analysis
Authors: Dong Yu , Yue Ming , Hu Mengjiao
Published: October 2021

Background. Rituximab has been frequently used as a second‐line treatment for patients with immune thrombocytopenia (ITP). The optimal dose and course of rituximab are uncertain. Methods. A comprehensive search for randomized controlled trials reporting the use of low‐dose (100 mg) or standard‐dose (375 mg/m2) rituximab in ITP treatment was conducted. Meta‐analyses were performed on CRR (complete response rate), ORR (overall response rate), PRR (partial response rate), SRR (sustained response rate), infection rate, SB (significant bleeding) rate, and SAE (serious adverse event) rate. Results. A total of 12 studies were included, comprising 869 patients. Compared to the control group, rituximab treatment resulted in an obvious increase in CRR (P < 0.00001), ORR (P < 0.0001), and SRR at month 6 and 12 (P = 0.0007, P = 0.0003), without increasing the infection rate (P = 0.12) and SAE rate (P = 0.11). No significant differences in CRR (RR 1.61 vs. 1.42, P = 0.45), ORR (RR 1.26 vs. 1.49, P = 0.28), PRR (RR 1.25 vs. 1.00, P = 0.11), SRR at month 12 (RR 2.00 vs. RR 1.64, P = 0.54), infection rate (RR 0.85 vs. 1.46, P = 0.36), and SB rate (RR 0.14 vs. 1.19, P = 0.17) were found in subgroups of low dose and standard dose. Conclusion. Rituximab was effective and safe for adult patients with ITP. A low‐dose rituximab regimen might be an effective alternative to the standard‐dose regimen in ITP, as it showed similar CRR, ORR, and SRR at month 12 and was relatively safer with a lower cost.
Mucin Expression and Splicing Determine Novel Subtypes and Patient Mortality in Pancreatic Ductal Adenocarcinoma
Authors: Thompson Christopher M. , Cannon Andrew , West Sean , Ghersi Dario , Atri Pranita , Bhatia Rakesh , Smith Lynette , Rachagani Satyayanarayana , Wichman Christopher , Kumar Sushil , Batra Surinder K.
Published: October 2021

Purpose:

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy demonstrating aberrant and progressive expression of mucins. The contribution of individual mucins has been extensively investigated in PDAC; however, comprehensive mucin profiling including splice variants in PDAC tumors has not been reported.

Experimental Design:

Using publicly available RNA sequencing (RNA-seq) datasets, we assess the expression of mucin family members and their splice variants (SV) in PDAC tumor samples for the first time. Mucin SVs that are correlated with PDAC patient survival are validated in a cohort of patient tumor samples. Further, we use computational methods to derive novel pancreatic tumor subtypes using mucin expression signatures and their associated activated pathways.

Results:

Principal component analysis identified four novel mucin-based PDAC subtypes. Pathway analysis implicated specific biological signatures for each subtype, labeled (i) immune activated, (ii) progressive, (iii) pancreatitis-initiated, and (iv) anti-inflammatory/PanIN-initiated. Assessing mucin SVs, significantly longer survival is observed with higher expression of 4 MUC1 and 1 MUC13 SVs, whereas patients expressing 2 MUC4 and 1 MUC16 SVs had shorter survival. Using a whole-transcriptome correlation, a three-gene panel, including ESRP2, PTK6, and MAGEH1, is designated to assess PDAC tumor sample cellularity by PCR. One MUC4 SV and one MUC13 SV are quantified in a separate PDAC patient cohort, and their effects on survival are experimentally validated.

Conclusions:

Altogether, we demonstrate the unique expression pattern of mucins, four mucin-based PDAC subtypes, and the contribution of MUC1, MUC4, and MUC16 SVs in PDAC patient survival.
Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations: Results from a Multi-institutional European Retrospective Study
Authors: Vincenzi Bruno , Napolitano Andrea , Fiocco Marta , Mir Olivier , Rutkowski Piotr , Blay Jean-Yves , Reichardt Peter , Joensuu Heikki , Fumagalli Elena , Gennatas Spyridon , Hindi Nadia , Nannini Margherita , Spalato Ceruso Mariella , Italiano Antoine , Grignani Giovanni , Brunello Antonella , Gasperoni Silvia , De Pas Tommaso , Badalamenti Giuseppe , Pantaleo Maria A. , van Houdt Winan J. , IJzerman Nikki S. , Steeghs Neeltje , Gelderblom Hans , Desar Ingrid M.E. , Falkenhorst Johanna , Silletta Marianna , Sbaraglia Marta , Tonini Giuseppe , Martin-Broto Javier , Hohenberger Peter , Le Cesne Axel , Jones Robin L. , Dei Tos Angelo P. , Gronchi Alessandro , Bauer Sebastian , Casali Paolo G.
Published: October 2021

Purpose:

The effect of high-dose imatinib (800 mg/day) on survival in the adjuvant treatment of patients with resected KIT exon 9–mutated gastrointestinal stromal tumors (GIST) is not established. Here, the association of dose and other clinicopathologic variables with survival was evaluated in a large multi-institutional European cohort.

Experimental Design:

Data from 185 patients were retrospectively collected in 23 European GIST reference centers. Propensity score matching (PSM) and inverse-probability of treatment weighting (IPTW) were used to account for confounders. Univariate and multivariate unweighted and weighted Cox proportional hazard regression models were estimated for relapse-free survival (RFS), modified-RFS (mRFS) and imatinib failure-free survival (IFFS). Univariate Cox models were estimated for overall survival.

Results:

Of the 185 patients, 131 (70.8%) received a starting dose of 400 mg/d and the remaining 54 (29.2%) a dose of 800 mg/d. Baseline characteristics were partially unbalanced, suggesting a potential selection bias. PSM and IPTW analyses showed no advantage of imatinib 800 mg/d. In the weighted multivariate Cox models, high-dose imatinib was not associated with the survival outcomes [RFS: hazard ratio (HR), 1.24; 95% confidence interval (CI), 0.79–1.94; mRFS: HR, 1.69; 95% CI, 0.92–3.10; IFFS: HR, 1.35; 95% CI, 0.79–2.28]. The variables consistently associated with worse survival outcomes were high mitotic index and nongastric tumor location.

Conclusions:

In this retrospective series of patients with KIT exon 9–mutated GIST treated with adjuvant imatinib, a daily dose of 800 mg versus 400 mg did not show better results in terms of survival outcomes. Prospective evaluation of the more appropriate adjuvant treatment in this setting is warranted.
Do Egito a Israel: passos silenciados e explosivos segundo O som de nossos passos, de Ronit Matalon
Authors: Rozenchan Nancy
Published: October 2021

A complexidade da vida de imigrantes judeus que foram obrigados a deixar o Egito e se instalaram em Israel há mais de meio século não significou para muitos deles uma possibilidade de ascensão na vida; ao contrário, a antiga posição de acomodamento foi substituída por um rebaixamento inesperado que somente atingiria um desejado equilíbrio na geração seguinte. Neste romance semiautobiográfico, Kol tseadeinu (O som de nossos passos, Am Oved, Tel Aviv, 2008), Ronit Matalon – filha de pais oriundos do Egito -, expõe a própria situação familiar. O verdadeiro ou fictício abonado padrão da família é substituído pelas duras condições de sobrevivência de tripla jornada de trabalho da mãe, ao qual se acresce o quase total abandono por parte do pai jornalista e ativista político marxista, insatisfeito com os moldes que o Israel de então lhes proporcionou na categoria de imigrantes mizrachim, ou seja, judeus provenientes de países árabes. O pai embarca em lutas para denunciar o modelo discriminador do país. A narrativa não linear do romance, conduzida pela filha - alter ego da autora, no papel de testemunha – da tenra idade à idade adulta, se concentra principalmente na mãe, Lucette, e sua atuação de lutadora para se sobrepor ao pequeno mundo a que fora restringida no novo país e à sua condição de esposa semiabandonada. Inconformada, “a mãe” abala a casa – um precário barracão pré-fabricado -, com suas movimentações. “A casa” – a vida da família – praticamente é sinônimo de “a mãe”. O propósito desse texto, além de situar a posição do romance na literatura hebraica contemporânea, é delinear o enfrentamento da mulher que conduz a sua vida e a de seus familiares para a frente, dos seus passos silenciosos, como se lê no primeiro capítulo, aos passos de toda a família, como expostos quase no final do alentado romance.
Myocardial Perfusion in Hypoplastic Left Heart Syndrome
Authors: Rickers Carsten , Wegner Philip , Silberbach Michael , Madriago Erin , Gabbert Dominik Daniel , Kheradvar Arash , Voges Inga , Scheewe Jens , Attmann Tim , Jerosch-Herold Michael , Kramer Hans-Heiner
Published: October 2021

Background:

The status of the systemic right ventricular coronary microcirculation in hypoplastic left heart syndrome (HLHS) is largely unknown. It is presumed that the systemic right ventricle’s coronary microcirculation exhibits unique pathophysiological characteristics of HLHS in Fontan circulation. The present study sought to quantify myocardial blood flow by cardiac magnetic resonance imaging and evaluate the determinants of microvascular coronary dysfunction and myocardial ischemia in HLHS.

Methods:

One hundred nineteen HLHS patients (median age, 4.80 years) and 34 healthy volunteers (median age, 5.50 years) underwent follow-up cardiac magnetic resonance imaging ≈1.8 years after total cavopulmonary connection. Right ventricle volumes and function, myocardial perfusion, diffuse fibrosis, and late gadolinium enhancement were assessed in 4 anatomic HLHS subtypes. Myocardial blood flow (MBF) was quantified at rest and during adenosine-induced hyperemia. Coronary conductance was estimated from MBF at rest and catheter-based measurements of mean aortic pressure (n=99).

Results:

Hyperemic MBF in the systemic ventricle was lower in HLHS compared with controls (1.89±0.57 versus 2.70±0.84 mL/g per min;
P
<0.001), while MBF at rest normalized by the rate-pressure product, was similar (1.25±0.36 versus 1.19±0.33;
P
=0.446). Independent risk factors for a reduced hyperemic MBF were an HLHS subtype with mitral stenosis and aortic atresia (
P
=0.017), late gadolinium enhancement (
P
=0.042), right ventricular diastolic dysfunction (
P
=0.005), and increasing age at total cavopulmonary connection (
P
=0.022). The coronary conductance correlated negatively with systemic blood oxygen saturation (r, −0.29;
P
=0.02). The frequency of late gadolinium enhancement increased with age at total cavopulmonary connection (
P
=0.014).

Conclusions:

The coronary microcirculation of the systemic ventricle in young HLHS patients shows significant differences compared with controls. These hypothesis-generating findings on HLHS-specific risk factors for microvascular dysfunction suggest a potential benefit from early relief of frank cyanosis by total cavopulmonary connection.
Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction
Authors: Zhang Qing-Jun , He Yu , Li Yongnan , Shen Huali , Lin Ling , Zhu Min , Wang Zhaoning , Luo Xiang , Hill Joseph A. , Cao Dian , Luo Richard L. , Zou Raymond , McAnally John , Liao Jun , Bajona Pietro , Zang Qun S. , Yu Yonghao , Liu Zhi-Ping
Published: October 2021

Rationale:

Cilp1 (cartilage intermediate layer protein 1) is a secreted extracellular matrix protein normally associated with bone and cartilage development. Its function and mechanism of action in adult heart disease remain elusive.

Objective:

To establish the function and mechanism of action of Cilp1 in postmyocardial infarction (MI) cardiac remodeling.

Methods and Results:

We investigated the expression of Cilp1 in mouse models of pathological cardiac remodeling and human heart failure patients. Cilp1 was expressed predominantly in cardiac fibroblasts and upregulated in response to cardiac injury and in the heart and blood of patients with heart failure. We generated
Cilp1
knock out (KO) and transgenic (Tg) mice with NCilp1 (N-terminal half of the protein) overexpressed in myofibroblasts.
Cilp1
KO mice had better cardiac function, reduced number of immune cells and myofibroblasts, and enhanced microvascular survival after MI compared with wild-type littermates. Conversely, NCilp1-transgenic mice had augmented loss of cardiac function, increased number of myofibroblasts and infarct size after the MI injury. RNA-seq and gene ontology analysis indicated that cell proliferation and mTORC1 (mammalian Target of Rapamycin Complex 1) signaling were downregulated in KO hearts compared with wild-type hearts. In vivo BrdU labeling and immunofluorescence staining showed that myofibroblast proliferation in the
Cilp1
KO heart was downregulated. Biaxial mechanical testing and extracellular matrix gene expression analysis indicated that while MI caused significant stiffness in wild-type hearts it had little effect on KO hearts. Upregulation of collagen expression after MI injury was attenuated in KO hearts. Recombinant CILP1 protein or NCilp1-conditioned medium promoted proliferation of neonatal rat ventricular cardiac fibroblasts via the mTORC1 signaling pathway.

Conclusions:

Our studies established a pathological role of Cilp1 in promoting post-MI remodeling, identified a novel function of Cilp1 in promoting myofibroblast proliferation, and suggested that Cilp1 may serve as a potential biomarker for pathological cardiac remodeling and target for fibrotic heart disease.
Assessment of an ECG‐Based System for Localizing Ventricular Arrhythmias in Patients With Structural Heart Disease
Authors: Zhou Shijie , AbdelWahab Amir , Sapp John L. , Sung Eric , Aronis Konstantinos N. , Warren James W. , MacInnis Paul J. , Shah Rushil , Horáček B. Milan , Berger Ronald , Tandri Harikrishna , Trayanova Natalia A. , Chrispin Jonathan
Published: October 2021

Background

We have previously developed an intraprocedural automatic arrhythmia‐origin localization (AAOL) system to identify idiopathic ventricular arrhythmia origins in real time using a 3‐lead ECG. The objective was to assess the localization accuracy of ventricular tachycardia (VT) exit and premature ventricular contraction (PVC) origin sites in patients with structural heart disease using the AAOL system.

Methods and Results

In retrospective and prospective case series studies, a total of 42 patients who underwent VT/PVC ablation in the setting of structural heart disease were recruited at 2 different centers. The AAOL system combines 120‐ms QRS integrals of 3 leads (III, V2, V6) with pace mapping to predict VT exit/PVC origin site and projects that site onto the patient‐specific electroanatomic mapping surface. VT exit/PVC origin sites were clinically identified by activation mapping and/or pace mapping. The localization error of the VT exit/PVC origin site was assessed by the distance between the clinically identified site and the estimated site. In the retrospective study of 19 patients with structural heart disease, the AAOL system achieved a mean localization accuracy of 6.5±2.6 mm for 25 induced VTs. In the prospective study with 23 patients, mean localization accuracy was 5.9±2.6 mm for 26 VT exit and PVC origin sites. There was no difference in mean localization error in epicardial sites compared with endocardial sites using the AAOL system (6.0 versus 5.8 mm,
P
=0.895).

Conclusions

The AAOL system achieved accurate localization of VT exit/PVC origin sites in patients with structural heart disease; its performance is superior to current systems, and thus, it promises to have potential clinical utility.
Tracking Blood Pressure Control Performance and Process Metrics in 25 US Health Systems: The PCORnet Blood Pressure Control Laboratory
Authors: Cooper‐DeHoff Rhonda M. , Fontil Valy , Carton Thomas , Chamberlain Alanna M. , Todd Jonathan , O’Brien Emily C. , Shaw Kathryn M. , Smith Myra , Choi Sujung , Nilles Ester K. , Ford Daniel , Tecson Kristen M. , Dennar Princess E. , Ahmad Faraz , Wu Shenghui , McClay James C. , Azar Kristen , Singh Rajbir , Faulkner Modrow Madelaine , Shay Christina M. , Rakotz Michael , Wozniak Gregory , Pletcher Mark J.
Published: October 2021

Background

The National Patient‐Centered Clinical Research Network Blood Pressure Control Laboratory Surveillance System was established to identify opportunities for blood pressure (BP) control improvement and to provide a mechanism for tracking improvement longitudinally.

Methods and Results

We conducted a serial cross‐sectional study with queries against standardized electronic health record data in the National Patient‐Centered Clinical Research Network (PCORnet) common data model returned by 25 participating US health systems. Queries produced BP control metrics for adults with well‐documented hypertension and a recent encounter at the health system for a series of 1‐year measurement periods for each quarter of available data from January 2017 to March 2020. Aggregate weighted results are presented overall and by race and ethnicity. The most recent measurement period includes data from 1 737 995 patients, and 11 956 509 patient‐years were included in the trend analysis. Overall, 15% were Black, 52% women, and 28% had diabetes. BP control (<140/90 mm Hg) was observed in 62% (range, 44%–74%) but varied by race and ethnicity, with the lowest BP control among Black patients at 57% (odds ratio, 0.79; 95% CI, 0.66–0.94). A new class of antihypertensive medication (medication intensification) was prescribed in just 12% (range, 0.6%–25%) of patient visits where BP was uncontrolled. However, when medication intensification occurred, there was a large decrease in systolic BP (≈15 mm Hg; range, 5–18 mm Hg).

Conclusions

Major opportunities exist for improving BP control and reducing disparities, especially through consistent medication intensification when BP is uncontrolled. These data demonstrate substantial room for improvement and opportunities to close health equity gaps.
Circulating miR‐19b‐3p as a Novel Prognostic Biomarker for Acute Heart Failure
Authors: Su Yang , Sun Yuxi , Tang Yansong , Li Hao , Wang Xiaoyu , Pan Xin , Liu Weijing , Zhang Xianling , Zhang Fenglei , Xu Yawei , Yan Chunxi , Ong Sang‐Bing , Xu Dachun
Published: October 2021

Background

Circulating microRNAs are emerging biomarkers for heart failure (HF). Our study aimed to assess the prognostic value of microRNA signature that is differentially expressed in patients with acute HF.

Methods and Results

Our study comprised a screening cohort of 15 patients with AHF and 5 controls, a PCR‐discovery cohort of 50 patients with AHF and 26 controls and a validation cohort of 564 patients with AHF from registered study DRAGON‐HF (Diagnostic, Risk Stratification and Prognostic Value of Novel Biomarkers in Patients With Heart Failure). Through screening by RNA‐sequencing and verification by reverse‐transcription quantitative polymerase chain reaction, 9 differentially expressed microRNAs were verified (miR‐939‐5p, miR‐1908‐5p, miR‐7706, miR‐101‐3p, miR‐144‐3p, miR‐4732‐3p, miR‐3615, miR‐484 and miR‐19b‐3p). Among them, miR‐19b‐3p was identified as the microRNA signature with the highest fold‐change of 8.4 and the strongest prognostic potential (area under curve with 95% CI, 0.791, 0.654–0.927). To further validate its prognostic value, in the validation cohort, the baseline level of miR‐19b‐3p was measured. During a follow‐up period of 19.1 (17.7, 20.7) months, primary end point comprising of all‐cause mortality or readmission due to HF occurred in 48.9% patients, while patients in the highest quartile of miR‐19b‐3p level presented the worst survival (Log‐rank
P
<0.001). Multivariate Cox model showed that the level of miR‐19b‐3p could independently predict the occurrence of primary end point (adjusted hazard ratio,1.39; 95% CI, 1.18–1.64). In addition, miR‐19b‐3p positively correlated with soluble suppression of tumorigenicity 2 and echocardiographic indexes of left ventricular hypertrophy.

Conclusions

Circulating miR‐19b‐3p could be a valuable prognostic biomarker for AHF. In addition, a high level of circulating miR‐19b‐3p might indicate ventricular hypertrophy in AHF subjects.

Registration

URL:
https://www.clinicaltrials.gov
. Unique Identifier: NCT03727828.
Impact of biochar amendment on soil nematode communities in a West African rain-fed rice cropland
Authors: Oladele Segun O. , Adeyemo Adebayo , Awodun Moses , Adegaye Ajoke , Ingold Mariko
Published: October 2021

Nematode population and diversity in a West African rain-fed rice cropland amended with biochar (B), biochar plus inorganic fertiliser (B + NPK), inorganic fertiliser (NPK) and control (CK) without amendments were investigated in a 3-year field study. Results demonstrated that significant differences exist between treatments and years of study for total nematode population and nematode trophic groups. Total nematode density, nematode trophic group (bacterivore and plant-parasitic) density were increased and dominant in B + NPK compared with CK after 3 years. Relative abundance of nematode genera according to trophic group across treatments showed Hirschmanniella (23%) as the dominant plant parasites in NPK, and Heterocephalobus (27%), Aphelenchoides (22%) and Eudorylaimus (9%) as dominant bacterivores, fungivores and omnivores-predators, respectively, in B + NPK. Trophic group indicators showed that the fungivore plus bacterivore to plant-parasitic ratio (73%) was significantly increased by B + NPK treatment in comparison to CK. Conversely, treatments exerted no significant effect on the fungivore to bacterivore ratio (F/B) throughout the period of study, which implies less disturbance and adverse impact of biochar on nematode communities. Apart from treatments and environmental factors, changes in nematode trophic groups were strongly related to soil chemical properties, such as soil pH, total nitrogen and available phosphorus, which shows their influence on soil nematode community. Our result shows the positive effect of integrated addition of biochar and inorganic fertiliser in balancing nematode diversity and building a resilient soil ecosystem in a low input rain-fed rice cropping system.
Two new insect-associated tylenchids, Sychnotylenchus hibisci n. sp. and Neoditylenchus xiphydriae n. sp. (Tylenchomorpha: Anguinidae), from Japan
Authors: Kanzaki Natsumi , Kajimura Hisashi , Masuya Hayato , Akiba Mitsuteru , Ekino Taisuke , Tsujimoto Satoshi , Kosaka Hajime
Published: October 2021

We isolated two tylenchid species belonging to the Sychnotylenchinae, Sychnotylenchus hibisci n. sp. and Neoditylenchus xiphydriae n. sp., from the bark beetle Ernoporus corpulentus and wood wasp Xiphydria ogasawarai, respectively. Sychnotylenchus hibisci n. sp. is characterised by its moderately stout body in both male and female, gubernaculum to spicule length ratio of one-third or less, crustaformeria structure composed of four columns with six large, rounded cells, and a broad female tail with a rounded terminus. The new species is closely related to S. ulmi, with which it shares body shape and gubernaculum to spicule length ratio, but is distinguished by the female tail shape and several morphometric values. Neoditylenchus xiphydriae n. sp. is characterised by its oval to leaf-shaped male bursa, male tail tip reaching the distal end of, and protruding beyond the bursa, a long post-vulval uterine sac (PUS), and a conical female tail with a narrowly rounded terminus. The species is typologically similar to N. pinophilus but is distinguished by its male spicule shape, gubernaculum to spicule length ratio, and longer PUS. Phylogenetically, the Sychnotylenchinae belongs under the Anguinidae (superfamily Sphaerularioidea) and is closely related to several Ditylenchus, Neotylenchus, Neomisticius, and Ficotylus species.
Meloidogyne enterolobii development and reproduction in tomato plants treated with resistance inducers
Authors: Silva Juliana de O. , Oliveira Camilla M. , Carneiro Renê G. da S. , da Rocha Mara R.
Published: October 2021

Meloidogyne enterolobii is a species capable of overcoming plant resistance moderated by the Mi-1 gene, which is effective against most species of root-knot nematode. This study evaluated the effect of induced resistance in tomato plants (Solanum lycopersicum ‘H-9553’) with the Mi-1 gene against the development and reproduction of M. enterolobii. Seedlings of tomato ‘H-9553’ were transplanted into pots, inoculated with 2000 eggs and second-stage juveniles (J2) of M. enterolobii and treated with Acibenzolar-S-Methyl, Bacillus subtilis, B. subtilis + B. licheniformis + Trichoderma longibrachiatum and extract of Reynoutria sachalinensis. The plants were collected at 5, 10, 15, 20, 25 and 30 days after inoculation (DAI) for the analyses of nematode penetration and development, and at 30 DAI for nematode reproduction. The use of B. subtilis increased fresh root weight when compared to the other treatments (20 DAI). There was a reduction in penetration of J2 in the roots of plants subjected to different resistance inducers. The population density of M. enterolobii was significantly reduced only when plants were treated with R. sachalinensis, indicating it as a potential resistance-inducing agent in tomato plants.
Solving an old dilemma: are the two sympatric species Lema apicalis and L. reticulosa (Coleoptera, Chrysomelidae, Criocerinae) morphotypes of a single species?
Authors: VON GROLL ELISA
Published: October 2021

Two species of Lema (Quasilema), L. apicalis Lacordaire, 1845 and L. reticulosa Clark, 1866 are compared and found to be identical based on morphology and behaviour, although they exhibit different colour patterns (Lema (subgenus Quasilema) apicalis Lacordaire, 1845 = Lema (Quasilema) reticulosa Clark, 1866 new synonym). These morphs are sympatric, with distribution in southern Brazil, Argentina, Paraguay, and Uruguay, and feed and oviposit on the same host plant (Vassobia breviflora (Sendtn.) Hunz (Solanaceae)).
New sacculonotic Oripodoidea (Acari: Oribatida) from Peru
Authors: ERMILOV SERGEY G. , SUBÍAS LUIS S. , SHTANCHAEVA UMUKUSUM YA. , FRIEDRICH STEFAN
Published: October 2021

Three new species of oribatid mites of the superfamily Oripodoidea—Scheloribates (Bischeloribates) eduardoi sp. nov., Scheloribates (Hemileius) dianae sp. nov. (both from Scheloribatidae) and Peloribates (Peloribates) elisabethae sp. nov. (Haplozetidae)—are described from soil and leaf litter of the primary evergreen lowland rainforest in Amazonian Peru. An identification key to known species of Scheloribates (Bischeloribates) is updated. The taxonomic status of the genus Tentaculozetes Balogh, 1970 (Haplozetidae) is discussed, resulting in the following new taxonomic proposal: Peloribates (Peloribates) Berlese, 1908 (=Tentaculozetes Balogh, 1970 syn. nov.).
New species and records of Chasmogenus Sharp, 1882 from the southwestern margin of the Guiana Shield (Coleoptera: Hydrophilidae: Acidocerinae)
Authors: GLYNN RACHEL D. , SHORT ANDREW EDWARD Z.
Published: October 2021

The Neotropical water scavenger beetle genus Chasmogenus Sharp, 1882 is a diverse lineage with 34 described species. Here, three new species from the southwestern margin of the Guiana Shield are described using an integrative approach combining adult morphology and molecular data: Chasmogenus clinatus sp. n. (Brazil: Amazonas, Venezuela: Amazonas), C. gironae sp. n. (Venezuela: Amazonas), and C. inpa sp. n. (Brazil: Amazonas). Examination of the male genitalia is essential for confident identifications and thus unassociated females may prove extremely difficult to identify. New distributional records in Brazil for C. acuminatus Smith & Short, 2020 are provided as well as habitus images of newly described species and an updated key to the species from Venezuela, Suriname, Guyana, French Guiana and northern Brazil.