bluuebunny/crossref_metadata_2025 huggingface dataset:
Ageing, limb-loss and military veterans: a systematic review of the literature
Authors: CADDICK NICK , CULLEN HELEN , CLARKE AMANDA , FOSSEY MATT , HILL MICHAEL , MCGILL GILL , GREAVES JANE , TAYLOR TERI , MEADS CATHERINE , KIERNAN MATTHEW D
Published: March 2018

The impact of losing a limb in military service extends well beyond initial recovery and rehabilitation, with long-term consequences and challenges requiring health-care commitments across the lifecourse. This paper presents a systematic review of the current state of knowledge regarding the long-term impact of ageing and limb-loss in military veterans. Key databases were systematically searched including: ASSIA, CINAHL, Cochrane Library, Medline, Web of Science, PsycArticles/PsychInfo, ProQuest Psychology and ProQuest Sociology Journals, and SPORTSDiscus. Empirical studies which focused on the long-term impact of limb-loss and/or health-care requirements in veterans were included. The search process revealed 30 papers relevant for inclusion. These papers focused broadly on four themes: (a) long-term health outcomes, prosthetics use and quality of life; (b) long-term psycho-social adaptation and coping with limb-loss; (c) disability and identity; and (d) estimating the long-term costs of care and prosthetic provision. Findings present a compelling case for ensuring the long-term care needs and costs of rehabilitation for older limbless veterans are met. A dearth of information on the lived experience of limb-loss and the needs of veterans’ families calls for further research to address these important issues.
Ringing the changes: the role of telephone communication in a helpline and befriending service targeting loneliness in older people
Authors: PRESTON CLAIRE , MOORE STEPHEN
Published: March 2018

The drive to deliver services addressing loneliness in older people by telephone and online makes it increasingly relevant to consider how the mode of communication affects the way people interact with services and the capacity of services to meet their needs. This paper is based on the qualitative strand of a larger mixed-methods study of a national phoneline tackling loneliness in older people in the United Kingdom. The research comprised thematic analysis of four focus groups with staff and 42 semi-structured interviews with callers. It explored the associations between telephone-delivery, how individuals used the services and how the services were able to respond. To understand these associations, it was useful to identify some constituent characteristics of telephone communication in this context: namely its availability, reach and non-visual nature. This enabled various insights and comparison with other communication media. For example, the availability of the services attracted people seeking frequent emotional support but this presented challenges to staff. More positively, the ability of the services to connect disparate individuals enabled them to form different kinds of satisfying relationships. The evolution of mixed communication forms, such as internet-based voice communication and smartphone-based visual communication, makes analysis at the level of a technology's characteristics useful. Such a cross-cutting perspective can inform both the design of interventions and assessment of their suitability for different manifestations of loneliness.
Older persons’ right to health – a challenge to international law
Authors: MIKOŁAJCZYK BARBARA
Published: March 2018

Over the next 30 years, the number of people aged over 65 will exceed the number of children worldwide. Moreover, people at extreme old age will constitute a significant group of older adults. Undoubtedly, global ageing appears as a great challenge to the whole international community in relation to the protection of rights of older persons, including their right to health. The last one is recognised on international forums as one of the most current and complex issues. Therefore, in this paper, I discuss how the right of older adults to health is protected by international norms, and identify trends and perspectives for implementing this right effectively. Examining the degree of protection, I analyse existing international instruments and their interpretation provided by international bodies. I consider that the new international developments should fill in the existing loophole in international law and oblige States to focus on elimination of ageism, age discrimination in access to health care and various barriers to enjoying the right to health by older persons.
School-based integrated curriculum: An integrated music approach in one Hong Kong kindergarten
Authors: Lau Wing Chi Margaret , Grieshaber Susan
Published: March 2018

The implementation of a school-based integrated curriculum enables schools to plan a balanced, flexible and coherent curriculum in order to reduce subject specification, especially in kindergartens. Despite kindergarten teachers in Hong Kong Special Administrative Region (SAR) being encouraged to integrate music content across subject areas, these boundaries still exist and prove challenging. This instrumental case study shows how one kindergarten teacher attempted to integrate other subjects into the music curriculum through movement and games, and encourage children's creativity. Eight detailed observations of music lessons and an interview with the kindergarten teacher depict her efforts at integration. Findings show that some progress was made and that the support of the principal was pivotal. They also suggest ways in which kindergarten teachers might begin to incorporate more creative integrated approaches to music education and have some applicability to other kindergarten settings where transmission approaches tend to dominate and teachers want to encourage music integration and children's musical creativity.
Exploring Student Learning and Leadership through a University-Community Choral Initiative
Authors: Kenny Ailbhe
Published: March 2018

Within a rapidly changing higher education landscape, there is an increased need for universities to look beyond their ‘ivory towers’ and into their surrounding communities in preparing students for the ‘real world’. Findings from an Irish case study explore a children's choral university-community initiative within an urban area of socio-economic disadvantage. The choral initiative involved 14 student volunteers and 150 children. Qualitative research, carried out over two years, involved student focus group interviews and reflective surveys. The research illuminates the multifaceted nature of the learning experience for students and examines to what extent such an initiative can build choral leadership capacity to work in school and community settings.
Using life histories with sound postcards to investigate a music programme for social reconstruction in Colombia
Authors: Rodríguez-Sánchez Andrea , Odena Oscar , Cabedo–Mas Alberto
Published: March 2018

This article outlines the development of an appropriate research approach, including methods from diverse disciplines, for researching the Colombian state-funded social music programme Music for Reconciliation(Música para la Reconciliación). After outlining the Colombian context and the literature, a pilot with ten participants is discussed. Findings show the contributions of sound postcards as part of life histories for capturing the experiences of displaced people in a country recovering from war. Their evocative capacity enriched the interviewees’ narrative, illustrating diverse sonorous landscapes throughout their lives that evidenced the changes generated by both the violence and programme participation. The conclusions offer suggestions for readers based in the arts, health, social sciences and beyond, interested in the uses of music and music education for other-than-musical purposes.
Identifying challenges and opportunities for student composer and performer peer learning through newly-composed classical piano scores
Authors: MacRitchie Jennifer , Zicari Massimo , Blom Diana
Published: March 2018

Limited consideration has been given to the challenges young composers and performers face when learning to communicate through notation in contemporary classical music, and the specific opportunities presented for peer learning. This article describes a project at a Swiss music conservatory in which two student composers wrote pieces for solo piano which were performed by three student pianists. Students were deprived of collaborative opportunities, with communication limited to score markings and legends. Results from individual interviews are discussed in relation to categories of approaches drawn from existing studies on learning new piano works, on notation and on collaboration, plus new categories arising from this research. The challenges and potential opportunities arising from this approach are examined here, highlighting specific areas to be targeted for future peer learning.
Doing gender beside or in music: Significance of context and discourse in close relationship in the Swedish music classroom
Authors: Källén Carina Borgström , Lindgren Monica
Published: March 2018

This article explores the significance of context and discourse from a gender perspective within three different studies of the Swedish music classroom, conducted in lower secondary school, upper secondary school and higher music education respectively. The theoretical point of departure is that gender performances as well as the music classroom are discursively constructed within a specific context. The result suggests that if discourse and context are directed towards music as identity and skill, gender is performed in music, but if the music classroom is constructed as educational, gender is performed beside music. A conclusion is therefore that the impact of gender in the music classroom has to be understood as a matter of school discourse and school context in close relationship. It is argued that studying the interplay between context and discourse can be a way ahead for understanding the complexity in the relationship between music education and gender.
Making music in early childhood: A study of the formats of participation
Authors: Pérez–Moreno Jèssica
Published: March 2018

This paper presents research carried out in a kindergarten in Catalonia with the aim of studying the different kinds of musical activity that take place during one school day. This is an ethnographic study where the researcher became an extra teacher in a group of one to two-year-olds and interacted with them musically. The methodology is based in a participatory observation approach and data are collected via video-recordings, field notes and a daily exchange of impressions and reflections with the teacher. The results show four different kinds of participation that determine the type of musical activity carried out when children are placed in the spotlight: (a) active audience, (b) performer pointer (c) performer proof with expert, and (d) performer proof without expert.
Blind Spots in International Law
Authors: KANETAKE MACHIKO
Published: March 2018

This editorial aims to foster debate on the possible roles of implicit social cognition in international law. The editorial is in part inspired by a book entitled Blindspot: Hidden Biases of Good People, written by Banaji and Greenwald, researchers of social psychology. According to them, a large set of implicit biases reside in our minds, which may influence our behaviour towards ourselves and others. It is safe to argue that international judges, arbitrators, diplomats, domestic officials who apply international law, and international legal scholars are not immune from implicit bias. Within international legal scholarship, some relevant experiments have already been conducted in unveiling decision makers’ intuitive and automatic thinking. While implicit bias is hard to identify and remedy, this editorial encourages international legal practitioners and scholars to diversify their own experiences and engage in the imagination of counter-stereotypes.
Physically feasible decomposition of Engino® toy models: A graph-theoretic approach
Authors: ANTONIOU E. N. , ARAÚJO A. , BUSTAMANTE M. D. , GIBALI A.
Published: March 2018

During the 125th European Study Group with Industry held in Limassol, Cyprus, 5–9 December 2016, one of the participating companies, Engino.net Ltd, posed a very interesting challenge to the members of the study group. Engino.net Ltd is a Cypriot company, founded in 2004, that produces a series of toy sets – the Engino® toy sets – consisting of a number of building blocks, which can be assembled by pupils to compose toy models. Depending on the contents of a particular toy set, the company has developed a number of models that can be built utilizing the blocks present in the set; however, the production of a step-by-step assembly manual for each model could only be done manually. The goal of the challenge posed by the company was to implement a procedure to automatically generate the assembly instructions for a given toy. In the present paper, we propose a graph-theoretic approach to model the problem and provide a series of results to solve it by employing modified versions of well-established algorithms in graph theory. An algorithmic procedure to obtain a hierarchical, physically feasible decomposition of a given toy model, from which a series of step-by-step assembly instructions can be recovered, is proposed.
Editorial for the Special Issue on Parallel and Concurrent Functional Programming
Authors: Keller Gabriele , Henglein Fritz
Published: March 2018

Functional languages are uniquely suited to providing programmers with a programming model for parallel and concurrent computing. This is reflected in the wide range of work that is currently underway, both on parallel and concurrent functional languages, as well as on bringing functional language features to other programming languages. This has resulted in a rapidly growing number of practical applications. The Journal of Functional Programming decided to dedicate a special issue to this field to showcase the state of the art in how functional languages and functional concepts currently assist programmers with the task of managing the challenges of creating parallel and concurrent systems.
The origins of Swiss wealth management? Genevan private banking, 1800–1840
Authors: Ugolini Stefano
Published: March 2018

Geneva is host to the most ancient and venerable private banks of Switzerland, but not much is known about the circumstances in which the city allegedly developed an early competitive advantage in wealth management. Using an extraordinary qualitative source (Jacques Mirabaud's papers, and especially his memoirs), this article outlines the microstructure of Genevan private banking at the time of its emergence in the early nineteenth century. It finds that in those years, wealth managers’ ‘raw material’ did not consist of foreign capital, but of a remarkably abundant stock of domestic capital. Financial and social factors were intertwined in producing a very hierarchical division of labour in the origination and distribution of international sovereign loans.
Thinking Beyond Aurangzeb and the Mughal State in a Late Eighteenth-Century Punjabi Braj Source
Authors: MURPHY ANNE
Published: March 2018

This article argues for the value of looking past the emperor Aurangzeb, in seeking to understand how he has been portrayed. The eighteenth century Braj source from Punjab examined here portrays local debates and conflicts at the centre, and the Mughal state at the periphery, of the project of communitarian self-formation. Here, the emperor operates from the outside. Internal communitarian concerns, particularly regarding caste inclusion, dominate, linking the text in question to larger questions around caste and community that emerged in early modern South Asia in a range of contexts.
The association between obesity and race among Brazilian adults is dependent on sex and socio-economic status
Authors: Araujo Marina Campos , Baltar Valéria Troncoso , Yokoo Edna Massae , Sichieri Rosely
Published: March 2018

Objective

To verify the association of race, independent of socio-economic status (SES), with obesity among Brazilian adults.

Design

We investigated data from the 2008–2009 Brazilian Household Budget Survey. Obesity was defined using the WHO classification. Self-declared race was classified as White, Black and ‘Pardo’ (Brown). Factor analysis with principal component extraction was used to derive the SES index. The association between race and obesity independent of SES, adjusted for demographic variables, was estimated using multiple logistic regression, accounting for the survey design. Interaction term between race and SES was tested.

Setting

Brazilian households (n 55 970).

Subjects

Adults aged 20–65 years (n 80 702).

Results

The prevalence of obesity was 14·9 %. The first factor explained 51 % of the variance and was used as a SES indicator. Odds of obesity increased with increasing SES level for men and for Black women, whereas Brown and White women showed a decrease of obesity. The association between race and obesity was modified by SES level in both sexes. At lower level of SES (−2 sd), Black and Brown in comparison to White men had 35 and 27 % decreased odds of obesity, respectively. For women, at lower SES level, only Black compared with White women had 30 % decreased odds of obesity. At the higher SES level (+2 sd), Black women compared with White presented a threefold increase of obesity.

Conclusions

Racial disparities in obesity are SES level- and sex-dependent in Brazil. Strategies exclusively targeting reductions in SES disparities are likely ineffective for decreasing racial disparities in obesity among women.
The habitable zone of Kepler-16: impact of binarity and climate models
Authors: Moorman S. Y. , Quarles B. L. , Wang Zh. , Cuntz M.
Published: March 2018

We continue to investigate the binary system Kepler-16, consisting of a K-type main-sequence star, a red dwarf and a circumbinary Saturnian planet. As part of our study, we describe the system's habitable zone based on different climate models. We also report on stability investigations for possible Earth-mass Trojans while expanding a previous study by B. L. Quarles and collaborators given in 2012. For the climate models, we carefully consider the relevance of the system's parameters. Furthermore, we pursue new stability simulations for the Earth-mass objects starting along the orbit of Kepler-16b. The eccentricity distribution as obtained prefers values close to circular, whereas the inclination distribution remains flat. The stable solutions are distributed near the co-orbital Lagrangian points, thus enhancing the plausibility that Earth-mass Trojans might be able to exist in the Kepler-16(AB) system.
Stellar clusters in the Gaia era
Authors: Bragaglia Angela
Published: March 2018

Stellar clusters are important for astrophysics in many ways, for instance as optimal tracers of the Galactic populations to which they belong or as one of the best test bench for stellar evolutionary models. Gaia DR1, with TGAS, is just skimming the wealth of exquisite information we are expecting from the more advanced catalogues, but already offers good opportunities and indicates the vast potentialities. Gaia results can be efficiently complemented by ground-based data, in particular by large spectroscopic and photometric surveys. Examples of some scientific results of the Gaia-ESO survey are presented, as a teaser for what will be possible once advanced Gaia releases and ground-based data will be combined.
White dwarfs in the Gaia era
Authors: Tremblay P.-E. , Gentile-Fusillo N. , Cummings J. , Jordan S. , Gänsicke B. T. , Kalirai J. S.
Published: March 2018

The vast majority of stars will become white dwarfs at the end of the stellar life cycle. These remnants are precise cosmic clocks owing to their well constrained cooling rates. Gaia Data Release 2 is expected to discover hundreds of thousands of white dwarfs, which can then be observed spectroscopically with WEAVE and 4MOST. By employing spectroscopically derived atmospheric parameters combined with Gaia parallaxes, white dwarfs can constrain the stellar formation history in the early developing phases of the Milky Way, the initial mass function in the 1.5 to 8 M⊙ range, and the stellar mass loss as well as the state of planetary systems during the post main-sequence evolution.
Astrometric Reduction of Cassini ISS Images of Enceladus in 2015 Based on Gaia DR1
Authors: Zhang Q. F. , Lainey V. , Vienne A. , Cooper N. J. , Peng Q. Y. , Wang N.
Published: March 2018

The Gaia DR1 catalogue stars are taken as reference ones to reduce the Cassini ISS images of Enceladus in 2015, and a total of 494 Cassini-centered astrometric observation are obtained in right ascension(α) and declination (δ) in the international Celestial Reference Frame(ICRF). Compared with JPL ephemerides SAT367, we derive that their mean residuals are a few tens meters in α*cos(δ) and a few kilometers in δ, and their standard deviation is not over 2 kilometers. Compared with the results from UCAC4 catalogue stars, The Gaia DR1 has the equivalent precision of reduction.
Gaia observations of naked-eye stars: status update
Authors: Sahlmann J. , Mora A. , Martín-Fleitas J. M. , Abreu A. , Crowley C. , Fink M.
Published: March 2018

ESA's Gaia space astrometry mission is performing an all-sky survey of stellar objects. At the beginning of the nominal mission in July 2014, an operation scheme was adopted that enabled Gaia to routinely acquire observations of all stars brighter than the original limit of G~6, i.e. the naked-eye stars. We present the current status and extent of those observations.
The thick disc according to Gaia-ESO
Authors: Howes Louise M. , Bensby Thomas
Published: March 2018

In the era of large spectroscopic surveys, it is vital that selection effects are taken into account when making conclusions about the stellar populations of the Galaxy. Here we use the Galactic disc sample of stars from the Gaia-ESO Survey internal data release 4 (GES iDR4), applying the published selection function to characterise the vertical extent of the chemically defined thick and thin discs.
Herbig Ae/Be stars with TGAS parallaxes in the HR diagram
Authors: Vioque Miguel , Oudmaijer René D. , Baines Deborah
Published: March 2018

The intermediate mass Herbig Ae/Be stars are young stars approaching the Main Sequence and are key to understanding the differences in formation mechanisms between magnetic low mass stars and non-magnetic high mass stars. A large fraction of known Herbig Ae/Be stars have TGAS parallaxes, which were used to derive luminosities and place 107 of these objects in the HR diagram, increasing the number of objects using directly determined parallaxes by a factor of 5. We also studied the characteristics of the infrared excesses of this set of Herbig Ae/Be stars and we linked our results to an evolutionary analysis.
Metallicity distribution functions using Gaia-DR1 data
Authors: Kordopatis Georges ,   RAVE collaboration
Published: March 2018

The metallicity distribution function (MDF) of the stellar components of the Milky Way hold valuable information regarding the processes that have taken place in the evolution of our Galaxy. In this proceeding, we investigate updates concerning the MDF now that the Tycho-Gaia Astrometric Solution (TGAS) catalogue has been released and that trigonometric distances are available. In particular, vertical changes and skewness of the MDF are investigated, together with the properties of the metal-rich stars in the sample, at different positions in the Galaxy.
Developing Automated Spectral Analysis Tools for Interstellar Features Extractionto Support Construction of the 3D ISM Map
Authors: Puspitarini L. , Lallement R. , Monreal-Ibero A. , Chen H.-C. , Malasan H. L. , Aprilia  , Arifyanto M. I. , Irfan M.
Published: March 2018

One of the ways to obtain a detailed 3D ISM map is by gathering interstellar (IS) absorption data toward widely distributed background target stars at known distances (line-of-sight/LOS data). The radial and angular evolution of the LOS measurements allow the inference of the ISM spatial distribution. For a better spatial resolution, one needs a large number of the LOS data. It requires building fast tools to measure IS absorption. One of the tools is a global analysis that fit two different diffuse interstellar bands (DIBs) simultaneously. We derived the equivalent width (EW) ratio of the two DIBs recorded in each spectrum of target stars. The ratio variability can be used to study IS environmental conditions or to detect DIB family.
Gaia DR1 completeness within 250 pc & star formation history of the Solar neighbourhood
Authors: Bernard Edouard J.
Published: March 2018

We took advantage of the Gaia DR1 to combine TGAS parallaxes with Tycho-2 and APASS photometry to calculate the star formation history (SFH) of the solar neighbourhood within 250 pc using the colour-magnitude diagram fitting technique. We present the determination of the completeness within this volume, and compare the resulting SFH with that calculated from the Hipparcos catalogue within 80 pc of the Sun. We also show how this technique will be applied out to ~5 kpc thanks to the next Gaia data releases, which will allow us to quantify the SFH of the thin disc, thick disc and halo in situ, rather than extrapolating based on the stars from these components that are today in the solar neighbourhood.
Galactic disk structure as revealed by LAMOST A stars
Authors: Chen B.-Q. , Liu X.-W. , Yuan H.-B. , Huang Y. , Xiang M.-S. , Wang C. , Tian Z.-J. , Zhang H.-W.
Published: March 2018

Using the spectroscopic distances of over 0.12 million A-type stars selected from the LAMOST Spectroscopic Survey of the Galactic Anti-center (LSS-GAC), we map their three-dimensional number density distributions in the Galaxy. These stellar number density maps allow an investigation of the Galactic young age thin disk structure with no a priori assumptions about the functional form of its components. The data show strong evidence for a significant flaring young disk. A more detail analysis show that the stellar flaring have different behaviours between the Northern and the Southern Galactic disks. The maps also reveal spatially coherent, kpc-scale stellar substructure in the thin disk. Finally, we detect the Perseus arm stellar overdensity at R ~ 10 kpc.
Optimisation of JWST operations with the help of Gaia
Authors: Sahlmann J. , Nelan E. G. , Chayer P. , McLean B. , Lallo M.
Published: March 2018

The James Webb Space Telescope (JWST) is scheduled for launch in 2018. To operate and observe efficiently, JWST will rely on various external astrometric and photometric catalogues, in particular the HST Guide Star Catalog (GSC), for instance to locate sources accurately on the sky. The incorporation of the Gaia astrometric catalog will improve the absolute astrometry of the GSC and is therefore relevant for JWST operations. We outline how the JWST Science and Operations Center hosted at the Space Telescope Science Institute (STScI) intends to use the Gaia survey results to improve upon operational aspects such as the guiding and the geometric focal plane characterisation of JWST.
Wide Binaries in TGAS: Search Method and First Results
Authors: Andrews Jeff J. , Chanamé Julio , Agüeros Marcel A.
Published: March 2018

Half of all stars reside in binary systems, many of which have orbital separations in excess of 1000 AU. Such binaries are typically identified in astrometric catalogs by matching the proper motions vectors of close stellar pairs. We present a fully Bayesian method that properly takes into account positions, proper motions, parallaxes, and their correlated uncertainties to identify widely separated stellar binaries. After applying our method to the >2 × 106stars in the Tycho-Gaia astrometric solution from Gaia DR1, we identify over 6000 candidate wide binaries. For those pairs with separations less than 40,000 AU, we determine the contamination rate to be ≈5%. This sample has an orbital separation (a) distribution that is roughly flat in log space for separations less than ~5000 AU and follows a power law ofa−1.6at larger separations.
Optical interferometry and Gaia parallaxes for a robust calibration of the Cepheid distance scale
Authors: Kervella Pierre , Mérand Antoine , Gallenne Alexandre , Trahin Boris , Borgniet Simon , Pietrzynski Grzegorz , Nardetto Nicolas , Gieren Wolfgang
Published: March 2018

We present the modeling tool we developed to incorporate multi-technique observations of Cepheids in a single pulsation model: the Spectro-Photo-Interferometry of Pulsating Stars (SPIPS). The combination of angular diameters from optical interferometry, radial velocities and photometry with the coming Gaia DR2 parallaxes of nearby Galactic Cepheids will soon enable us to calibrate the projection factor of the classical Parallax-of-Pulsation method. This will extend its applicability to Cepheids too distant for accurate Gaia parallax measurements, and allow us to precisely calibrate the Leavitt law's zero point. As an example application, we present the SPIPS model of the long-period Cepheid RS Pup that provides a measurement of its projection factor, using the independent distance estimated from its light echoes.
Unveiling the stellar halo with TGAS
Authors: Veljanoski Jovan , Posti L. , Helmi A. , Breddels M. A.
Published: March 2018

The detailed study of the Galactic stellar halo may hold the key to unlocking the assembly history of the Milky Way. Here, we present a machine learning model for selecting metal poor stars from the TGAS catalogue using 5 dimensional phase-space information, coupled with optical and near-IR photometry. We characterise the degree of substructure in our halo sample in the Solar neighbourhood by measuring the velocity correlation function.
Placental mitochondrial biogenesis and function was slightly changed by gestational hypercholesterolemia in full-term pregnant women
Authors: Le Z.-Y. , Dong S. , Zhang R. , Cai X.-P. , Gao A. , Xiao R. , Yu H.-L.
Published: March 2018

It was reported that high blood cholesterol levels increased the susceptibility to mitochondrial dysfunction. This study hypothesized that the gestational hypercholesterolemia (HC) could induce the mitochondrial dysfunction in term human placenta. The eligible pregnant women were recruited from Xuanwu Hospital in Beijing during their first prenatal visit (before their 10th week of pregnancy). In total, 19 pregnant women whose serum total cholesterol levels were higher than 7.25 mmat third trimester (measured at 36–38 weeks) were selected as gestational HC. Other 19 pregnant women with normal cholesterol level matched with age, pre-gestational body mass index, and the neonatal gender were included as the control group. Full-term placenta samples were collected. The mitochondrial DNA (mtDNA) copy number, messenger RNA (mRNA) expression of cytochrome c oxidase subunit I, adenosine triphosphate monophosphatase 6 (ATP6ase), citrate synthase, peroxisome proliferator-activated receptor-γ (PPARγ) co-activator 1α, PPARγ co-activator 1β and estrogen-related receptor-α, and the activity of mitochondrial respiratory chain enzyme complex were measured. Pregnancy outcomes were obtained by extraction from medical records and the labor ward register. The results showed that only placental mtDNA copy number and mRNA expression of ATP6ase were significantly decreased in HC group. No significant differences were detected of other measurements between the two groups. These findings indicated that gestational HC might not induce the damage of placental function seriously.
Assessment of Solidago×niederederi Origin Based on the Accumulation of Phenolic Compounds in Plant Raw Materials
Authors: Radušienė Jolita , Marksa Mindaugas , Karpavičienė Birutė
Published: March 2018

This study provides the first phytochemical characterization of the morphologically identified natural hybrid Solidago×niederederi Khek compared with the native Solidago virgaurea and two invasive species, Canada goldenrod (Solidago canadensis L.) and giant goldenrod (Solidago gigantea Aiton). The phenolic compounds, namely, chlorogenic acid, rutin, isoquercitrin, hyperoside, and quercitrin, were detected in leaves and inflorescences by the high-performance liquid chromatography–photodiode array detector/ultraviolet (PAD/UV) method. All analyzed Solidago species contained all of the phenolic compounds investigated. The quantitative phytochemical differentiation among Solidago taxa was shown by principal component analysis. The results indicated that S. gigantea plants were characterized by significantly different quantities of phenolic compounds compared with three other Solidago taxa, which formed a separate cluster in the space of the principal component model, indicating the high similarity of their profiles. An additional multivariate analysis of the three species studied revealed a chemical gradient from S. canadensis to S. virgaurea with a slightly overlapping zone on the score plots presented by S.×niederederi and S. virgaurea accessions. The results showed that S.×niederederi was closely related to S. virgaurea. This result is suggestive of a hybrid origin with significant contributions from the native species. However, S.×niederederi was significantly different from its parental species with respect to chlorogenic acid and quercitrin in leaves and rutin with isoquercitrin in inflorescences. Conversely, samples indicating intermediate chemical composition between native S. virgaurea and invasive S. gigantea were not distinguished. The comparison of phenolic compound accumulation in Solidago plants supported the additional identification of the origin of S.×niederederi.
A Psychological Description of the Swiss Labor Market from 1991 to 2014
Authors: Ghetta Anja , Hirschi Andreas , Herrmann Anne , Rossier Jérôme
Published: March 2018

Abstract. This study conducted a representative analysis of the Swiss labor market from 1991 to 2014 by applying Holland’s (1997) classification of occupations according to six vocational interest types: realistic, investigative, artistic, social, enterprising, and conventional (RIASEC). Using data from the Swiss Labor Force Survey, we found that, over this period, realistic occupations consistently represented the largest share of jobs, albeit with a declining tendency. Increased numbers of people were employed in social and enterprising types of work. The lowest numbers were found in artistic and investigative occupations. Gender segregation along the six RIASEC occupational types were found on the Swiss labor market as well, with most men working in realistic and most women working in social occupations. Furthermore, we observed large salary differences between the six occupational types, even after controlling for required skill level. In line with findings concerning gender pay inequality, men earned more than women in each RIASEC occupational type in each year. Moreover, we found that RIASEC occupations differed meaningfully with regard to skill level, and that the required skill level increased across all RIASEC occupations over the examined 23-year period.
Personenzentriert pflegen am Universitätsspital Basel
Authors: Grossmann Florian F. , Barandun Schäfer Ursi , van Lieshout Famke , Frei Irena Anna
Published: March 2018

Zusammenfassung. Der Begriff personenzentrierte Gesundheitsversorgung ist in aller Munde. Man könnte vermuten, dass es sich dabei um ein modisches Schlagwort handelt. Tatsächlich bezeichnet der Begriff ein theoretisch fundiertes Wertesystem, das weltweit zunehmend Beachtung findet.
PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway
Authors: Lei Zhong , Duan Huijie , Zhao Tengfei , Zhang Yuxiang , Li Guoqi , Meng Jiahong , Zhang Suzhan , Yan Weiqi
Published: March 2018

Osteosarcoma (OS) is the most common primary malignant bone tumor mainly occurring in children and adolescents. In past decades, studies revealed that PARK2 was a vital tumor suppressor gene in many malignant solid tumors. However, the role of PARK2 in OS remains largely unclear. Therefore, we assessed PARK2 expression in OS tissue and adjacent non-tumor tissues by immunohistochemical (IHC) analysis, and evaluated PARK2 mRNA expression in OS cell lines by real-time PCR analysis. The HOS and U2OS cell lines were employed to establish a PARK2 overexpression model. Using this model, we investigated the potential role of PARK2 in OS and explored the underlying molecular mechanisms. Our study showed PARK2 was downregulated in OS tissue and cell lines, which was significantly associated with higher tumor stage (P < 0.05). Overexpression of PARK2 arrested the cell cycle, inhibited cell proliferation, migration, and invasion, induced cell apoptosis, and reduced tube formation in vitro. Moreover, overexpression of PARK2 significantly suppressed tumor growth and angiogenesis in vivo. Additionally, PARK2 negatively regulated OS development through the JAK2/STAT3/VEGF pathway. Our findings demonstrate that PARK2 is a tumor suppressor gene that may negatively affect OS growth and angiogenesis via partly inhibiting the JAK2/STAT3/VEGF signaling pathway.
Uniaxial strain control of spin-polarization in multicomponent nematic order of BaFe2As2
Authors: Kissikov T. , Sarkar R. , Lawson M. , Bush B. T. , Timmons E. I. , Tanatar M. A. , Prozorov R. , Bud’ko S. L. , Canfield P. C. , Fernandes R. M. , Curro N. J.
Published: March 2018

The iron-based high temperature superconductors exhibit a rich phase diagram reflecting a complex interplay between spin, lattice, and orbital degrees of freedom. The nematic state observed in these compounds epitomizes this complexity, by entangling a real-space anisotropy in the spin fluctuation spectrum with ferro-orbital order and an orthorhombic lattice distortion. A subtle and less-explored facet of the interplay between these degrees of freedom arises from the sizable spin-orbit coupling present in these systems, which translates anisotropies in real space into anisotropies in spin space. We present nuclear magnetic resonance studies, which reveal that the magnetic fluctuation spectrum in the paramagnetic phase of BaFe2As2 acquires an anisotropic response in spin-space upon application of a tetragonal symmetry-breaking strain field. Our results unveil an internal spin structure of the nematic order parameter, indicating that electronic nematic materials may offer a route to magneto-mechanical control.
Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
Authors: Tian Yanchen , Fan Min , Qin Zhaoxia , Lv Hongjun , Wang Minmin , Zhang Zhe , Zhou Wenying , Zhao Na , Li Xiaohui , Han Chao , Ding Zhaojun , Wang Wenfei , Wang Zhi-Yong , Bai Ming-Yi
Published: March 2018

Hydrogen peroxide (H2O2) is an important signaling molecule in plant developmental processes and stress responses. However, whether H2O2-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H2O2 induces the oxidation of the BRASSINAZOLE-RESISTANT1 (BZR1) transcription factor, which functions as a master regulator of brassinosteroid (BR) signaling. Oxidative modification enhances BZR1 transcriptional activity by promoting its interaction with key regulators in the auxin-signaling and light-signaling pathways, including AUXIN RESPONSE FACTOR6 (ARF6) and PHYTOCHROME INTERACTING FACTOR4 (PIF4). Genome-wide analysis shows that H2O2-dependent regulation of BZR1 activity plays a major role in modifying gene expression related to several BR-mediated biological processes. Furthermore, we show that the thioredoxin TRXh5 can interact with BZR1 and catalyzes its reduction. We conclude that reversible oxidation of BZR1 connects H2O2-mediated and thioredoxin-mediated redox signaling to BR signaling to regulate plant development.
GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
Authors: Takaku Motoki , Grimm Sara A. , Roberts John D. , Chrysovergis Kaliopi , Bennett Brian D. , Myers Page , Perera Lalith , Tucker Charles J. , Perou Charles M. , Wade Paul A.
Published: March 2018

GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their mechanistic impact on the breast cancer transcriptional network. Here, we address molecular and clinical features associated with GATA3 mutations. A novel classification scheme defines distinct clinical features for patients bearing breast tumors with mutations in the second GATA3 zinc-finger (ZnFn2). An engineered ZnFn2 mutant cell line by CRISPR–Cas9 reveals that mutation of one allele of the GATA3 second zinc finger (ZnFn2) leads to loss of binding and decreased expression at a subset of genes, including Progesterone Receptor. At other loci, associated with epithelial to mesenchymal transition, gain of binding correlates with increased gene expression. These results demonstrate that not all GATA3 mutations are equivalent and that ZnFn2 mutations impact breast cancer through gain and loss-of function.
Author Correction: nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor
Authors: Facchinello N. , Skobo T. , Meneghetti G. , Colletti E. , Dinarello A. , Tiso N. , Costa R. , Gioacchini G. , Carnevali O. , Argenton F. , Colombo L. , Valle L. Dalla
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Theory of isolated magnetic skyrmions: From fundamentals to room temperature applications
Authors: Büttner Felix , Lemesh Ivan , Beach Geoffrey S. D.
Published: March 2018

Magnetic skyrmions are topological quasiparticles of great interest for data storage applications because of their small size, high stability, and ease of manipulation via electric current. However, although models exist for some limiting cases, there is no universal theory capable of accurately describing the structure and energetics of all skyrmions. The main barrier is the complexity of non-local stray field interactions, which are usually included through crude approximations. Here we present an accurate analytical framework to treat isolated skyrmions in any material, assuming only a circularly-symmetric 360° domain wall profile and a homogeneous magnetization profile in the out-of-plane direction. We establish the first rigorous criteria to distinguish stray field from DMI skyrmions, resolving a major dispute in the community. We discover new phases, such as bi-stability, a phenomenon unknown in magnetism so far. We predict materials for sub-10 nm zero field room temperature stable skyrmions suitable for applications. Finally, we derive analytical equations to describe current-driven dynamics, find a topological damping, and show how to engineer materials in which compact skyrmions can be driven at velocities >1000 m/s.
Statistically derived asymmetric membrane potentials from α-helical and β-barrel membrane proteins
Authors: Koehler Leman Julia , Bonneau Richard , Ulmschneider Martin B.
Published: March 2018

Modeling membrane protein (MP) folding, insertion, association and their interactions with other proteins, lipids, and drugs requires accurate transfer free energies (TFEs). Various TFE scales have been derived to quantify the energy required or released to insert an amino acid or protein into the membrane. Experimental measurement of TFEs is challenging, and only few scales were extended to depth-dependent energetic profiles. Statistical approaches can be used to derive such potentials; however, this requires a sufficient number of MP structures. Furthermore, MPs are tightly coupled to bilayers that are heterogeneous in terms of lipid composition, asymmetry, and protein content between organisms and organelles. Here we derived asymmetric implicit membrane potentials from β-barrel and α-helical MPs and use them to predict topology, depth and orientation of proteins in the membrane. Our data confirm the ‘charge-outside’ and ‘positive-inside’ rules for β-barrels and α-helical proteins, respectively. We find that the β-barrel profiles have greater asymmetry than the ones from α-helical proteins, as a result of the different membrane architecture of gram-negative bacterial outer membranes and the existence of lipopolysaccharide in the outer leaflet. Our data further suggest that pore-facing residues in β-barrels have a larger contribution to membrane insertion and stability than previously suggested.
Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents
Authors: Rees Julian A. , Deblonde Gauthier J.-P. , An Dahlia D. , Ansoborlo Camille , Gauny Stacey S. , Abergel Rebecca J.
Published: March 2018

Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents (GBCAs) for MRI, prompting the European Medicines Agency to recommend discontinuing the use of over half of the GBCAs currently approved for clinical applications. To address this problem, we find that the orally-available metal decorporation agent 3,4,3-LI(1,2-HOPO) demonstrates superior efficacy at chelating and removing Gd from the body compared to diethylenetriaminepentaacetic acid, a ligand commonly used in the United States in the GBCA Gadopentetate (Magnevist). Using the radiotracer 153Gd to obtain precise biodistribution data, the results herein, supported by speciation simulations, suggest that the prophylactic or post-hoc therapeutic use of 3,4,3-LI(1,2-HOPO) may provide a means to mitigate Gd retention in patients requiring contrast-enhanced MRI.
Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions
Authors: Bruzzese Agustín , Gil Carles , Dalton James A. R. , Giraldo Jesús
Published: March 2018

Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their effects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD) simulations, totalling 24 μs, to rigorously map allosteric modulation and conformational changes in the β2 adrenergic receptor (β2AR) that occur as a result of interactions with three different phospholipids. In particular, we identify different sequential mechanisms behind receptor activation and deactivation, respectively, mediated by specific lipid interactions with key receptor regions. We show that net negatively charged lipids stabilize an active-like state of β2AR that is able to dock Gsα protein. Clustering of anionic lipids around the receptor with local distortion of membrane thickness is also apparent. On the other hand, net-neutral zwitterionic lipids inactivate the receptor, generating either fully inactive or intermediate states, with kinetics depending on lipid headgroup charge distribution and hydrophobicity. These chemical differences alter membrane thickness and density, which differentially destabilize the β2AR active state through lateral compression effects.