bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological Evidence Management at the Crime Scene: An Overview
Authors: Neeraj Kumar  , Ajay Kumar Gautam  , Pawan Kumar Prajapati  , SubhraKumar Paul  , Sanjeev K Gupta  , Anurag Sharma  , Deepa Verma
Published: July 2023

Crime scene serves as the starting point for forensic science and can generate valuable data that must bemeticulously, methodically, scientifically, and lawfully gathered. If the crime scene is not handled appropriately,it can become misleading and render crucial information useless, leading to an investigation on the wrong path.Forensic science has undergone a revolution thanks to the use of DNA technologies. Many times, due to theinvestigator’s lack of scientific expertise regarding the proper collection, preservation, storage, and transportationof biological evidence, the investigator is unable to acquire accurate DNA analysis results, which reduces the valueof the evidence in court. Purity, quantity, and rate of DNA degradation are just a few of the many variables thatgo into creating a decent DNA profile from a biological sample. We highlight and provide useful strategies andrecommendations to assist medical, forensic, and law enforcement professionals in handling biological evidencesfor DNA analysis to prevent contamination, deterioration, and loss of biological evidence’s value.
Ministry of Agriculture's Public Relations Strategy Through the Millennial Farmer Program
Authors: Vellycia Vellycia
Published: July 2023

As the world keeps advancing due to globalization, countries across the world were competing against each other to be more acknowledgeable. The use of nation branding appears to be better suited to solve that problem. The use of public diplomacy such as gastrodiplomacy is believed to be the perfect tool in achieving that goal. South Korea was one of the many countries to do so. The country does not solely rely on the concept of gastrodiplomacy alone, rather it combines diplomacy with the use of media and entertainment industry. This research aims to elaborate the use of Korean television programs as the medium for cultural representation through gastrodiplomacy performed within. This research attempts to interpret gastrodiplomacy performances within the Korean drama, 'Weightlifting Fairy: Kim Bok-Joo' and Korean reality show, 'BTS: In The Soop' by applying diplomacy and performance concept, and food as nation branding theory. This study shows that television drama and reality show were able to create an engagement and connection with their audience, making both shows effective in delivering the message. The research will be carried out using qualitative research measurement, by analyzing the food appearances happening within the selected scenes from both the series.
The temporal visual oddball effect is not caused by repetition suppression
Authors: Saurels Blake W. , Yarrow Kielan , Lipp Ottmar V. , Arnold Derek H.
Published: July 2023

The oddball paradigm is commonly used to investigate human time perception. Trains of identical repeated events (‘standards’) are presented, only to be interrupted by a different ‘oddball’ that seems to have a relatively protracted duration. One theoretical account has been that this effect is driven by repetition suppression for repeated standards. The idea is that repeated events seem shorter as they incur a progressively reduced neural response, which is supported by the finding that oddball perceived duration increases linearly with the number of preceding repeated standards. However, typical oddball paradigms confound the probability of oddball presentations with variable numbers of standard repetitions on each trial, allowing people to increasingly anticipate an oddball presentation as more standards are presented. We eliminated this by making participants aware of what fixed number of standards they would encounter before a final test input and tested different numbers of standards in separate experimental sessions. The final event of sequences, the test event, was equally likely to be an oddball or another repeat. We found a positive linear relationship between the number of preceding repeated standards and the perceived duration of oddball test events. However, we also found this for repeat tests events, which speaks against the repetition suppression account of the temporal oddball effect.
LexCHI: A quick lexical test for estimating language proficiency in Chinese
Authors: Wen Yun , Qiu Yicheng , Leong Christine Xiang Ru , van Heuven Walter J. B.
Published: July 2023

A prominent methodological issue in cognitive research on bilingualism is the lack of consistency in measuring second language (L2) proficiency. To reduce the inconsistency in L2 proficiency measurements, brief and valid vocabulary tests have been developed as an objective measure of proficiency in a variety of languages (e.g., English, French, Spanish). Here, we present LexCHI, a valid lexical test to measure Chinese proficiency. This freely available short test consists of 60 two-character items presented in simplified Chinese. Although it only takes a few minutes to complete LexCHI, the LexCHI scores in two studies correlated significantly with L2 participants' performance in a translation task and a cloze test. We believe that LexCHI is a useful tool for researchers who need to objectively measure Chinese proficiency as part of their investigations.
oREV: An item response theory-based open receptive vocabulary task for 3- to 8-year-old children
Authors: Bohn Manuel , Prein Julia , Koch Tobias , Bee R. Maximilian , Delikaya Büsra , Haun Daniel , Gagarina Natalia
Published: July 2023

Individual differences in early language abilities are an important predictor of later life outcomes. High-quality, easy-access measures of language abilities are rare, especially in the preschool and primary school years. The present study describes the construction of a new receptive vocabulary task for children between 3 and 8 years of age. The task was implemented as a browser-based web application, allowing for both in-person and remote data collection via the internet. Based on data from N = 581 German-speaking children, we estimated the psychometric properties of each item in a larger initial item pool via item response modeling. We then applied an automated item selection procedure to select an optimal subset of items based on item difficulty and discrimination. The so-constructed task has 22 items and shows excellent psychometric properties with respect to reliability, stability, and convergent and discriminant validity. The construction, implementation, and item selection process described here makes it easy to extend the task or adapt it to different languages. All materials and code are freely accessible to interested researchers. The task can be used via the following website: https://ccp-odc.eva.mpg.de/orev-demo.
Procesos argumentativos para el desarrollo del Pensamiento Histórico
Authors: Valencia Chávez Erik Rowan , Mejía Mejía Angela Liliana
Published: July 2023

El desarrollo de competencias argumentativas para comprender hechos históricos es fundamental en la vida cultural y social de los estudiantes, ya que les proporciona herramientas esenciales para entender el contexto en el que se encuentran inmersos. Para lograr este objetivo, se empleó un diseño metodológico cualitativo-descriptivo, el cual se enfocó en proporcionar a los estudiantes las habilidades y aptitudes necesarias para utilizar el conocimiento del pasado de forma organizada. Se aplicó un instrumento para evaluar los niveles de argumentación de los estudiantes y se encontró que estos mostraron un desarrollo de capacidades argumentativas, lo cual indica su comprensión del hecho histórico trabajado. El desarrollo de competencias argumentativas en los estudiantes implica la capacidad de formular argumentos basados en evidencia histórica, y de expresarlos de manera clara y coherente. Esta habilidad les permite analizar y comprender los diferentes aspectos de la Colonia Hispanoamericana, como su contexto político, económico y social, así como las consecuencias que tuvo en la región fomentando pensamiento crítico. La comprensión de hechos históricos como la Colonia Hispanoamericana es fundamental para que los estudiantes comprendan su propia identidad y la realidad en la que viven. En este sentido, la investigación realizada contribuye a fortalecer la educación histórica de los estudiantes y a promover una visión crítica y reflexiva del pasado
Autoeficacia para actividad física en adultos mayores con diabetes mellitus II de San Bartolomé Tlaltelulco
Authors: Romero Salazar Itzel Jariseth , Álvarez Orozco María Eugenia , Madin Juárez Berenice , Gómez Martínez Vicenta
Published: July 2023

La diabetes mellitus se ha incrementado de forma considerable en las últimas décadas, lo que representa ahora un problema de salud pública a nivel mundial por lo que la Organización Mundial de la Salud OMS (2023) ha considerado necesario evitar o retrasar las consecuencias de esta enfermedad en la población a través de una vida más sana, que incluya una mejor alimentación y ejercicio. Olivari y Urra (2007) refieren que la autoeficacia influye de forma positiva o negativa en comportamientos como lo afectivo, cognitivo y conductual.  El objetivo fue analizar el nivel de actividad física auto eficiente en adultos mayores con diabetes mellitus tipo II de una comunidad mexiquense. Estudio de enfoque metodológico tipo cuantitativo, no experimental, transversal con alcance descriptivo, con una muestra de 50 adultos mayores en edades comprendidas entre 60 a 65 años que radican en San Bartolomé Tlaltelulco, se utilizó bajo consentimiento informado, el Cuestionario Internacional de Actividad Física (IPAQ) y la Escala de Autoeficacia para la Actividad Física (EAF) de Fernández Cabrera et al (2011) por su confiabilidad y validación para evaluar el nivel de autoeficacia. El 53% de los adultos mayores con DMTII tuvieron una autoeficacia “Media” para realizar actividad física.
NUTRITION RESEARCH PRODUCTIVITY AND TRENDS IN INDIA: A BIBLIOMETRIC ANALYSIS
Authors: Gohil Trushna A. , Makwana Dr. Jignesh C.
Published: July 2023

Nutrition is an important supplement for the growth and the development of the human beings. In this pandemic of COVID19, the health has become a prime importance and whole world focusing on building immunity by maintain the balanced and healthy diet. Many researchers put emphasis on what to eat when to eat and how maintain all the nutrients. Looking to the importance of the field, in this paper an attempt has been made to analyse the literature available on Nutrition. Bibliometrics is a statistical tool used to analyse the track of researcher output and its impact. For this the bibliometric analysis was carried to predict the most prolific authors, journals, growth of literature, country collaboration. The data was retrieved from the web of science; it is the world’s most trusted global citation database. In total there are 3686 articles published on Nutrition from 2010 to 2019, in India. Most of the publication output is in Journal of Food Science and Technology, Mysore with 114 publications and 3355 citations. The top ranked author is Kumar A with 78 articles and 1280 citations. It was observed that there is continuous growth in literature and henceforth, it’s a time to adopt a holistic life to have natural immunity by natural food.
Peranan Komunikasi Pemasaran Dalam Meningkatkan Minat Studi Mahasiswa
Authors: Sri Marini  , Superwiratni  , Ita Karnita
Published: July 2023

Tingginya animo calon mahasiswa untuk memilih perguruan tinggi di bidang pariwisata dan perhotelan menjadikan AKPAR NHI Bandung tidak sendiri dalam hal ini. Hal tersebut menjadikan peluang untuk mendapatkan calon mahasiswa menjadi lebih sulit. AKPAR NHI Bandung harus dapat memiliki differensiasi agar menjadi prioritas calon mahasiswa. Hal tersebut harus distimuli dengan menumbuhkan minat mahasiswa untuk dapat melanjutkan pendidikan di program studi perhotelan. Minat merupakan perilaku konsumen yang menunjukkan sejauh mana komitmennya dalam melakukan pembelian. Diperlukan pemasaran yang baik sehingga target perguruan tinggi swasta dalam menjaring calon mahasiswa dapat lebih fokus, dan strategi pemasaran tersebut perlu di komunikasikan melalui komunikasi pemasaran yang efektif. Rumusan masalah penelitian ini adalah bagaimana komunikasi pemasaran yang dilakukan  dan bagaimana minat studi mahasiswa. Tujuan penelitian ini adalah untuk menganalisa aktivitas komunikasi pemasaran  dan minat studi mahasiswa. Key Informan dalam penelitian ini adalah informan internal dari 2 pengelola promosi yaitu marcom dan tim promosi, serta 15 informan sebagai narasumber eligible yang memiliki peran sebagai mahasiswa dari angkatan 2021, 2022 dan calon mahasiswa baru  untuk memberi informasi mengenai minat dalam studi. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis data kualitatif yang dilakukan secara interaktif melalui proses data reduction, data display, dan verification. Hasil penelitian menunjukkan bahwa peranan komunikasi pemasaran penting dalam meningkatkan minat studi mahasiswa sehingga berdampak terhadap keberlangsungan lembaga pendidikan pariwisata dan perhotelan.
Potential combined effect of Spirulina platensis and Momordica charantia fruits on attenuation of isoproterenol-induced myocardial infarction in rats: identification and prediction its mechanism
Authors: Prasesti Gayuk Kalih , Anggadiredja Kusnandar , Kurniati Neng Fisheri
Published: July 2023

We established in vivo models of isoproterenol-induced myocardial infarction (MI) to determine the cardioprotective effect of Spirulina platensis (Spi), Momordica charantia fruit (MC) and their combination. MI was induced in six groups of Male Wistar albino with isoproterenol, and cardioprotection was evaluated by measuring SGOT, SGPT, LDH, CK, CK-MB with commercially available test kits and analyzing histopathology. Online PASS was used to predict the mechanism of action of a marker compound in Spi and MC. Rat serum levels of LDH, SGOT, CK-MB, and CK were significantly reduced by the Spi and MC combination extract (P < 0.05). The combination extract at a dose of 50:50 mg/kg body weight preserve the integrity of the myocardial cell membrane. Identified compounds by LC-MS/MS in the ethanol extract of Momordica charantia are (3β,16α-Dihydroxy-lanosta-8,24-dien-21-oic acid), Eclalbasaponin II, Epianhydrobelachinal, Epianhydrobelachinal, Paeonenolide F, Ziyu glycoside II. Identified compounds by LC-MS/MS in Spirulina platensis extract are d-Lirioferine, Lycopodine, Yuanhunine, Candidate Mass C18H26N2O5 and Candidate Mass C36H38N4O5. In PASS analysis, Phycocyanobilin’s cardioprotective mechanism of action is predicted to be kinase inhibitor, cytoprotectant, and platelet aggregation inhibitor, with Probable activities (Pa) of 0.06, 0.53, and 0.443, respectively. The Pa values for cholesterol antagonist, proliferative disease treatment, nitric oxide scavenger, and anti-inflammatory agents in Momordicoside A are respectively 0.841, 0.666, 0.59, and 0.55. These findings suggest that the cardioprotective activity of the combination of Spi and MC extracts at a dose of 50 mg/kg was synergistic.
Mathematical models for the formation and evaluation of manufacturing cells in a textile company: A case study
Authors: Naranjo Israel , Porras María , Ortiz Daysi , Tigre Franklin , Sánchez Carlos , Tubón Edith , Carrillo Sandra , Mariño Christian , López Jéssica , Lema Freddy , Rosero César
Published: July 2023

Purpose: Use mathematical models of Mixed Integer Linear Programming oriented to cellular distribution and aggregate production planning in order to obtain the appropriate product family for each manufacturing cell and from this, minimize production and material handling costs through the allocation of production resources.Design/methodology/approach: This article develops two mathematical models in LINGO 18.0 software, performing the computational calculation to obtain the best efficiency in cell formation at minimum production cost.Findings: The mathematical model oriented to the formation of manufacturing cells allows a grouping of products and machines with 82.5% group efficiency. By reallocating machines to each cell and redistributing facilities, the cost of material handling is reduced by 35.1%, and the distance traveled in product manufacturing is reduced by 26.6%. The mathematical model of aggregated planning provides information on production resource requirements such as personnel, machinery, distances traveled, as well as the cost generated by the need to outsource part of the production, inventory maintenance and overtime work.Research limitations/implications: It is necessary to clearly define the capacity variables. The model does not take into account the cost of mobilizing machines and readjusting facilities.Practical implications: The case study company can adequately plan production and efficiently manage its resources.Social implications: The study can be applied to other textile SMEs.Originality/value: The aggregate production planning model requires the assignment of the mathematical model of manufacturing cell formation in order to calculate the resource requirements needed to meet a demand.
Using Teaching Videos to Improve Nursing Students' Self-Efficacy in Managing Patient Aggression
Authors: Harlan Melissa D. , Bench Victor , Hudack Christoph , Fennimore Laura , Sherwood Paula , Ren Dianxu , Kelly Linda K.
Published: July 2023

Background:

Nursing students experience patient aggression due to their age and lack of experience. Academic institutions can implement strategies to prepare students to manage aggression.

Method:

One-hundred forty-eight undergraduate nursing students in a baccalaureate nursing program participated in this quality improvement initiative. Baseline and postintervention perceived self-efficacy (PSE) data were gathered using the Self-Efficacy in Patient Centeredness Questionnaire-27. Students viewed two educational videos and underwent debriefing.

Results:

Overall PSE scores increased significantly (
p
< .01) from baseline (
M
= 76.44,
SD
= 13.00) to postintervention (
M
= 91.66,
SD
= 11.97). PSE in the subscales exploring the patient's perspective, sharing information and power, and dealing with communication challenges increased significantly (
p
< .01) from pre- to postintervention.

Conclusion:

PSE in caring for patients exhibiting aggressive behavior increased after nursing students were taught behaviors to use and how to manage their own biases to avoid provoking patients to respond aggressively.

[
J Nurs Educ
. 2023;62(7):423–426.]
Nursing Students' Medication Administration: A Focus on Hand Hygiene and Patient Identification
Authors: Schroers Ginger , O'Rourke Jenny
Published: July 2023

Background:

Procedural failures during medication administration include a lack of appropriate hand hygiene and failure to verify patient identification prior to administration of medication. Procedural failures are common among nurses and nursing students and can lead to serious patient harm.

Method:

A descriptive cross-sectional research design was used to collect observational data from a simulation-based experience of a medication administration scenario.

Results:

Thirty-five senior baccalaureate nursing students from two geographically distant universities in the United States participated in the study. All of the participants made at least one procedural failure during the simulated experience. Hand hygiene compliance was 40.3%, and patient identification compliance was 43.8%.

Conclusion:

Students often failed to comply with medication administration safety guidelines. Nursing programs must make changes to the methods used to teach safe medication administration to prepare students for this critical skill.

[
J Nurs Educ
. 2023;62(7):403–407.]
Aftermarket performance of green IPOs and portfolio allocation
Authors: Mumtaz Muhammad Zubair , Yoshino Naoyuki
Published: July 2023

This study examines the aftermarket performance of high-green and low-green IPO and how green IPOs can optimize portfolio allocation. We assume the higher level of greenness increases investors' participation in IPOs. To this end, we develop the utility function and determine that investors prefer to participate in new issues when firms account for greenness measures. This study proposes the global aspects of green measure: the desired level of greenness a firm maintains. We find that IPOs in our sample are far below the global standards of greenness. This evidence suggests they must adopt the necessary actions to make the environment green. Another significant contribution of this study is to measure the performance of high and low-green IPOs in short- and long-run horizons. This study reveals that high-green IPOs are less underpriced. This study estimates the effect of greenness on initial returns and finds an inverse relationship suggesting that high-green IPOs are less underpriced due to lower risk associated with new issues. In terms of measuring longer-term performance, this study determines that high-green IPOs underperform less than low-green IPOs.
Characterizing non-totally geodesic spheres in a unit sphere
Authors: Al-Dayel Ibrahim , Deshmukh Sharief , Belova Olga
Published: July 2023

A concircular vector field $ \mathbf{u} $ on the unit sphere $ \mathbf{S}^{n+1} $ induces a vector field $ \mathbf{w} $ on an orientable hypersurface $ M $ of the unit sphere $ \mathbf{S}^{n+1} $, simply called the induced vector field on the hypersurface $ M $. Moreover, there are two smooth functions, $ f $ and $ \sigma $, defined on the hypersurface $ M $, where $ f $ is the restriction of the potential function $ \overline{f} $ of the concircural vector field $ \mathbf{u} $ on the unit sphere $ \mathbf{S}^{n+1} $ to $ M $ and $ \sigma $ is defined as $ g\left(\mathbf{u}, N\right) $, where $ N $ is the unit normal to the hypersurface. In this paper, we show that if function $ f $ on the compact hypersurface satisfies the Fischer–Marsden equation and the integral of the squared length of the vector field $ \mathbf{w} $ has a certain lower bound, then a characterization of a small sphere in the unit sphere $ \mathbf{S}^{n+1} $ is produced. Additionally, we find another characterization of a small sphere using a lower bound on the integral of the Ricci curvature of the compact hypersurface $ M $ in the direction of the vector field $ \mathbf{w} $ with a non-zero function $ \sigma $.
Pilot estimators for a kind of sparse covariance matrices with incomplete heavy-tailed data
Authors: Li Huimin , Wang Jinru
Published: July 2023

This paper investigates generalized pilot estimators of covariance matrix in the presence of missing data. When the random samples have only bounded fourth moment, two kinds of generalized pilot estimators are provided, the generalized Huber estimator and the generalized truncated mean estimator. In addition, we construct thresholding generalized pilot estimator for a kind of sparse covariance matrices and establish the convergence rates in terms of probability under spectral and Frobenius norms respectively. Moreover, the convergence rates in sense of expectation are also given under an extra condition. Finally, simulation studies are conducted to demonstrate the superiority of our method.
Contribution of Online Tutoring in Promoting the Quality of Distance Learning for Moroccan Teachers
Authors: Tahiri Abdelmajid , Chikhaoui Ahmida , Assermouh Jalal , Halim Mohamed , Benfares Samiha
Published: July 2023

This paper aims at highlighting the contribution of online tutoring to the quality of distance learning (DL) and its effect on the progress and success of learners. The aim is, therefore, to judge the role of the tutor and the effect of his or her intervention on satisfying the real needs of Moroccan teachers in terms of learning during continuous training in DL mode. This study is grounded on a literature review regarding the effectiveness of tutoring and the qualitative analysis of data collected from a series of semi-structured interviews with actors (N=20) involved in the DL of Moroccan teachers. This study was achieved by the analysis of the results of a questionnaire returned by teachers (sample n=180) who were beneficiaries of the DL entitled “Communication in the Classroom,” which was provided by the Distance Learning for Students, Teachers and Professionals Association (FADEEP). The results emphasize the importance of factors relating to the effectiveness of tutoring in the quality of the DL and, more particularly, to the relevance of the tutor’s answers and his or her availability on the platform—and consequently, in the success of the learner—in addition to the material and technical, pedagogical, organizational, socio-political, and socio-cultural factors and factors linked to the learner of course.
The “Who” in Engineering: Sociotechnical Engineering as Memorable and Relevant
Authors: Chen Diana A. , Forbes Marissa H. , Hoople Gordon D. , Lord Susan M. , Mejia Joel Alejandro
Published: July 2023

Does emphasizing the role of people in engineering influence the memorability of engineering content? This study is part of a larger project through which our team developed a new undergraduate energy course to better reflect students’ cultures and lived experiences through asset-based pedagogies to help students develop a sociotechnical mindset in engineering problem solving. In this study, students in the class were invited to participate in semi-structured interviews (n=5) to explore our effectiveness in helping them develop a sociotechnical mindset around energy issues and conceptualize engineering as a sociotechnical endeavor. This study focuses on an activity during the interview where the participants were asked to sort a variety of images associated with class learning experiences along a spectrum of least to most memorable. Emergent themes from students’ responses revolved around learning experiences that included global perspectives and emphasized a “who” (i.e., whose problems, who is impacted by engineering, and what type of engineers the students will choose to become) as the most memorable. Our results indicate that students found the sociotechnical aspects of the course more memorable than the traditional canonical engineering content. These findings suggest that framing engineering content as sociotechnical can be one strategy to increase student engagement, increase memorability of lessons, and help students to think more deeply about their own goals as future engineers.
Spatial Strategies Employed by Blind and Low-Vision (BLV) Individuals on the Tactile Mental Cutting Test (TMCT)
Authors: Green Theresa , Goodridge Wade H. , Kane Daniel , Shaheen Natalie L.
Published: July 2023

Spatial ability is a well-known predictor of success in science, technology, engineering, and mathematics (STEM) fields. The purpose of this study was to investigate and understand the spatial strategies that were used by blind and low-vision (BLV) individuals as they solved problems on the tactile mental cutting test (TMCT), an instrument that was designed to measure the spatial ability of BLV audiences. The TMCT is an accessible adaptation of the older, 1938 version of the mental cutting test (MCT) that has been used extensively in spatial ability research. Additionally, this paper seeks to compare these strategies with existing strategies that have been investigated with sighted populations. The BLV community is underrepresented in engineering and in spatial ability research. By understanding how BLV students understand and solve spatial problems and concepts, educators can develop and enhance educational content that is relevant to this population. By incorporating perspectives from the BLV community and making STEM curricula accessible to this population, more BLV individuals may be encouraged to pursue STEM or engineering career pathways.
Approche globale et intégrée d’un habitat groupé antique lémovice : le cas de Bridiers à La Souterraine (Creuse, Nouvelle-Aquitaine)
Authors: Baret Florian , Jubeau Thomas
Published: July 2023

Depuis 2019, de nouveaux travaux menés dans le cadre du PCR HaGAL – Habitat Groupé Antique de la cité des Lémovices (dir. F. Baret) ambitionnent de reprendre de manière approfondie et globale l’étude de l’agglomération antique de Bridiers (La Souterraine, Creuse). Ces derniers ont démarré par la réalisation d’une prospection géoradar sur une parcelle d’environ 1 ha révélant un dense quartier de l’habitat groupé structuré par trois axes de circulation, jusqu’ici inédit. Les résultats obtenus offrent pour la première fois la possibilité d’établir un plan d’une partie de l’occupation. À la suite de cette première opération (qui succède toutefois à deux campagnes de prospections pédestres et à un levé LiDAR), une campagne de fouilles exploratoires a été menée en 2020 sur l’un des bâtiments mis en évidence. Ces données inédites, qu’il est par ailleurs intéressant de confronter, renouvellent sensiblement les connaissances sur une importante agglomération de la cité des Lémovices. Cette contribution ambitionne par la présentation des résultats, des deux opérations, de souligner l’intérêt de croiser les différents types d’opération et les échelles d’acquisition des données pour étudier finement une agglomération antique dans le cadre du développement de recherches nouvelles.
Premières données xylo- et anthraco-entomologiques à l’époque gallo-romaine
Authors: Toriti Magali , Durand Aline , Fohrer Fabien
Published: July 2023

Cet article propose un premier état des connaissances sur la petite vrillette (Anobium punctatum De Geer, 1774), à partir de données archéobotaniques. L’analyse systématique des traces de ce xylophage et sa présence récurrente sur différents sites gallo-romains documentent les processus de déconstruction d’un bâtiment et éclairent des pratiques comme le réemploi. Elles aident aussi à comprendre l’attractivité du bois dans le domaine de la conservation patrimoniale. Les études des galeries et des vermoulures (identification, comptage, localisation), alliées aux éléments xylologiques et anthracologiques (essence ligneuse, anatomie), sont confrontées aux données archéologiques : elles révèlent un fort potentiel d’aide aux interprétations des bois archéologiques, notamment des bois ouvragés (charpente, plancher). En raison de sa synanthropie et de sa biologie, cet insecte est ubiquiste. Il peut être considéré comme un marqueur archéologique. Lorsqu’il est identifié, il est possible d’obtenir des informations sur la source de l’infestation de la structure et sur son importance. Ainsi, l’état sanitaire des bois est évalué. Parfois, des contextes archéologiques différents (four, foyer) renseignent plutôt sur le réemploi d’anciens bois ouvrés. Enfin, lorsqu’il est absent alors que toutes les conditions semblent réunies pour son implantation, d’autres questionnements se posent : traitement des bois, âge de la structure, tanins contenus dans les essences…
A Modified Cosmetic Technique for Head and Neck Dissection in Autopsy Especially for Bald-headed Deceased
Authors: Appuhamy P.
Published: July 2023

The autopsy is a specialized procedure in which a pathologist performs a thorough external and internal examination including dissection of the organs from different body cavities such as cranial, thoracic, abdominal, and pelvic. In such dissection of an intact dead body, disfiguration and destruction are likely. When viewed during a funeral service, the currently practiced conventional autopsy dissection techniques can result in minimal tell-tale autopsy marks on the body of the deceased, in exposed areas of the head and neck even when the other areas of the body are covered with clothing. We propose a modification to the conventional skin incision over the head and neck in a way that the incision is placed over the back of the head and neck compared to the conventional incision over the sides of the head and sides of the neck. In this way, the incisions and their stitch marks are hidden, making them cosmetically sound. Although the exposure gained through the proposed method is similar to the conventional method additional incisions over the back of the neck with the additional turning of the body from supine to prone can increase the time duration of the autopsy compared to the conventional method. Moreover, in this method, the incisions are invisible even in a bold-headed deceased as the head incision is placed over the back.
The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy
Authors: Villalba Nuria , Sackheim Adrian M , Lawson Michael A , Haines Laurel , Chen Yen-Lin , Sonkusare Swapnil K , Ma Yong-Tao , Li Jianing , Majumdar Devdoot , Bouchard Beth A , Boyson Jonathan E , Poynter Matthew E , Nelson Mark T , Freeman Kalev
Published: July 2023

Drugs are needed to protect against the neutrophil-derived histones responsible for endothelial injury in acute inflammatory conditions such as trauma and sepsis. Heparin and other polyanions can neutralize histones but challenges with dosing or side effects such as bleeding limit clinical application. In this study, we demonstrate that suramin, a widely available polyanionic drug, completely neutralizes the toxic effects of individual histones, but not citrullinated histones from neutrophil extracellular traps. The sulfate groups on suramin form stable electrostatic interactions with hydrogen bonds in the histone octamer with a dissociation constant of 250 nM. In cultured endothelial cells (Ea.Hy926), histone-induced thrombin generation was significantly decreased by suramin. In isolated murine blood vessels, suramin abolished aberrant endothelial cell calcium signals and rescued impaired endothelial-dependent vasodilation caused by histones. Suramin significantly decreased pulmonary endothelial cell ICAM-1 expression and neutrophil recruitment caused by infusion of sublethal doses of histones in vivo. Suramin also prevented histone-induced lung endothelial cell cytotoxicity in vitro and lung edema, intra-alveolar hemorrhage, and mortality in mice receiving a lethal dose of histones. Protection of vascular endothelial function from histone-induced damage is a novel mechanism of action for suramin with therapeutic implications for conditions characterized by elevated histone levels.
Analytical Model Development for Rotors Hovering Above Heaving Surfaces
Authors: Milluzzo Joseph , Tritschler John K. , Davids Scott
Published: July 2023

A potential flow model was developed for rotors hovering in-ground-effect above a heaving surface using a similar methodology to classical, analytical, static ground effect models. Experimental performance measurements for rotors hovering above a surface undergoing single degree-of-freedom
heaving motion were used for model validation, and potential mission trends were generated for a representative naval helicopter. Unlike prior empirical models, the current model was able to capture the effect of rotor hub height as well as ground motion parameters. A new thrust ratio was
proposed that compared the thrust produced in-ground-effect above a heaving surface to that produced above a static surface. Better agreement was found to occur at the higher collective pitch settings and hub heights, with the model predicting the classical thrust ratio within 5% of the measured
value for approximately 75% of the test points. The thrust ratio relative to a static surface was found to produce better agreement, and approximately 80% of the experimental tests points were predicted within 5% of the measured value.
Paradigm Shift in Management of Hyperglycemia in Patients with Type 2 Diabetes: Glucocentric versus Organ Protection
Authors: Won Jong Chul
Published: July 2023

The first research for managing patients with type 2 diabetes (T2DM) was the UK Prospective Diabetes Study. Subsequent studies have investigated the effects of intensive glucose control on diabetes-associated morbidities and mortality. Study results were intended to change a paradigm to control glycated hemoglobin and prevent diabetes-associated complications, but limited in microvascular diseases rather than diabetes-associated cardio-renal diseases and deaths. Comprehensive management of risk factors other than hyperglycemia (hypertension, dyslipidemia, chronic kidney disease) was emphasized to prevent atherosclerotic cardiovascular (CV) diseases and end-stage renal disease in T2DM. Since 2008, based clinical trials demonstrating CV safety, sodium-glucose transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists have shown beneficial effects on macrovascular and renal complications in patients with T2DM. A recent new paradigm of diabetes care focuses on cardio-renal outcome-oriented care, namely organ-protection, instead of the typical glucocentric view endorsed by major societies across the world including the Korean Diabetes Association and disseminated into clinical practice even in primary care. Although there are many mechanisms by which those glucose-lowering agents protect CV and renal disease in patients with T2DM to be clarified, it is time to redefine diabetes care and to verify the CV effect of anti-diabetic medications beyond glucose lowering.
A Phase-IV Multicentric Study to Evaluate Postmarketing, Real-World, Additional Safety, and Efficacy Data for TenecteRelR (Tenecteplase)
Authors: Apsangikar Prasad Dattatray , Rathod Sumeet M. , Yadav Ajaykumar R. , Kagane Sachin Namdeorao , Sonowal Supriya J.
Published: July 2023

Background:

Fibrin-specific lytic agents like tenecteplase (TNK) have improved the patency rates substantially. Real-world postmarketing safety and efficacy evaluation hold lot of importance.

Objectives:

The present study was a prospective, multicenter, phase IV study to evaluate postmarketing safety and efficacy of TenecteRel® (TNK).

Methods:

The present study was a postmarketing multicenter, phase IV study to evaluate postmarketing safety and efficacy of TenecteRel®. Two hundred and two patients of STEMI presenting within 6 h of onset of symptoms, were included in the study. A single dose of tenecte was administered and patients were followed up till day 30. Safety evaluation included adverse events monitoring, physical examination, vital signs, and immunogenicity assessment. Efficacy assessment was based on mortality and nonfatal stroke at 30 days and rates of bleeding events and nonfatal inhospital cardiac events.

Results:

A total of 69 treatment-emergent adverse events (TEAEs) were reported. There were 42 (20.79%) patients who had at least one TEAE and 9 (4.46%) patients with TEAE related to study medication. Most commonly reported (≥5%) TEAEs were related to gastrointestinal disorders 17 (8.42%) and general disorders and administration site conditions 13 (6.93%). One hundred and ninety-four (96.04%) patients had the net clinical benefit (defined as the absence of mortality and nonfatal stroke at day 30). No patient had an incidence of stroke. Bleeding events were 3 (1.49%) all of which were nonserious and minor in nature.

Conclusions:

The present phase IV study confirms that TenecteRel® of Reliance Life Sciences is well tolerated and the safety and efficacy profile is comparable to the innovator product data.
Evaluation of Salivary IL-8 and Calcium Levels in Postmenopausal Females with and without periodontitis—A Comparative Study
Authors: Potdar Raksha , Ramesh Amitha , Rajesh Aparna
Published: July 2023

Background and Objective:

Menopause is a normal developmental stage in a woman's life marking the permanent cessation of menstruation. Calcium is predominant in intracellular signalling and its intracellular increase can affect the cell's proliferation, phagocytosis and cytokine secretion. IL-8 expression in various cells such as neutrophils and osteoblasts was reported to involve a calcium signalling pathway. Well-known functions of IL-8 includes help in angiogenesis, role in tumour progression, tissue remodelling, etc., Hence, the aim of this study was to establish the relationship between calcium-dependent IL-8 and periodontal disease in postmenopausal females.

Method:

The study population included 52 postmenopausal women aged 45–57 years. The patients were divided into two groups in which group I included postmenopausal women without periodontitis and group II with periodontitis. Unstimulated salivary samples were collected from all the participants to evaluate IL-8 and calcium levels.

Results:

There was a statistically significant difference in salivary IL-8 levels between the two groups (P < 0.001), but there was no statistical difference in salivary calcium levels between the two groups (P = 0.730). A weak negative correlation between salivary IL-8 and calcium was found in group I, while a weak positive correlation was found between the same in group II.

Conclusion:

Analysis of salivary IL-8 from the present study was in accordance with several previous studies. It can be concluded that saliva can also be used as a reliable oral diagnostic fluid for IL-8 and calcium detection in periodontitis.
Calcitonin as a Pharmacological Anchorage in Orthodontics
Authors: Pizzo-Reis Patrícia M. , Coêlho Mônica C. , Azevedo Ricardo B. , Faber Jorge
Published: July 2023

Objective:

This study aimed to evaluate the effects of salmon calcitonin administration as a pharmacological anchoring agent in orthodontics and to determine the influence of locally applied calcitonin on serum calcium levels. The secondary aim was to observe the response of dental and periodontal tissues using light microscopy.

Methods:

Fourteen healthy male adult Wistar rats with an average weight of 250 g had their teeth moved, seven of which received a local injection of salmon calcitonin in the furcation region of the left upper first molar. Concurrently, the remaining seven were used as controls. In the control group, saline solution was injected in the bifurcation region of tooth 26 to subject these animals to the same stress level as those of the experimental group. After 14 days, a 6 mm diameter orthodontic elastic band was inserted between teeth 26 and 27 in all animals to induce the movement of these teeth. The rats were anaesthetised and exsanguinated on day 21. In both groups, tooth movement and serum calcium levels were measured. The jaws were dissected with straight scissors, and tissue blocks containing gingiva, bone and teeth were identified, fixed and demineralised. Then, the pieces were cut into semi-serial slices, stained with hematoxylin, eosin, and Mallory's trichrome, and analysed under an Axiophot light microscope.

Results:

There was significantly less tooth movement in the experimental group (X[Combining Macron]; 0,150 mm ± 0,037) than in the control group (0,236 mm ± 0,044; P = 0,003), while there was no significant difference in serum calcium levels between the two groups (controlX[Combining Macron]; 9,53 mg/dl ± 1,53; experimental 10,81 mg/dl ± 1,47; P = 0,15).

Conclusion:

While calcitonin did not completely inhibit osteoclast activity, it promoted orthodontic anchorage, apparently, by local action.
Socioeconomic Determinants of Demand for Dental Cosmetic Treatments
Authors: Emrani Reza
Published: July 2023

Introduction:

The demand for cosmetic dentistry is a growing trend globally. Increased media coverage, availability of free online information, and the improved economic status of the general population have led to an increase in the patient's aesthetic expectations. Since no study has measured the relationship between the economic status of people and the choice of cosmetic dentistry in Iran and due to the growing demand for it, this study was designed.

Method:

In this descriptive epidemiological study, we visited three completely different areas in terms of Socioeconomic status (SES) in Tehran. A checklist was used to record the gender, job, age, education level, maternal status, and source of payment for cosmetic dentistry treatment.

Result:

The majority of the volunteers for dental cosmetic restoration were 23-26 years. Of 498 cosmetic restoration volunteers, 50 were men and 448 were women. As for the education level, most of the participants had a high school diploma. The cost of cosmetic restoration of 351 patients (70%) was paid by the parents or the spouse, and 147 patients paid the cost from their income. Our study showed that 7% of visits to dental clinics were only for cosmetic treatment demands in Tehran in 2021.

Conclusion:

Type of job, education level, and marital status had no significant relationship with the choice of cosmetic treatment while age had a significant relationship with the choice of cosmetic dental restoration treatment. In addition, the choice of cosmetic dental treatment was completely related to gender, and women were the main users of it.
Unicystic Ameloblastoma - A Case Series
Authors: Rajasekaran Arulmozhi M. , Prasad Cheruvathur , Balaji J. , Arunkumar K. , Raghavan Priyadharshini
Published: July 2023

Ameloblastoma is a benign, locally aggressive neoplasm that constitutes about 1–3% of the tumors of the jaw. Wide surgical excision with adequate safe margin is the most common treatment of choice. The study aimed to manage cases with unicystic ameloblastoma while preserving the continuity of the mandible (without resection). This article presents a series of cases ranging from 18 to 40 years old patients of both sexes with unicystic ameloblastoma, especially in the mandible showing more male predilection than female. All the cases presented in this article were treated by enucleation and curettage. None of the patients presented post-operative paresthesia. None of the cases went in for resection. Post-operative recovery was uneventful in all the patients. All the patients were followed up for a period of 3.5–5 years. None of the cases reported recurrence at the date of publication.
Application of Platelet-Rich Fibrin and Freeze-Dried Bone Allograft Following Apicoectomy
Authors: Garg Madhur , Srivastava Vipul , Chauhan Raju , Pramanik Saurabh , Khanna Rinee
Published: July 2023

Background:

Apicoectomy conceptualizes surgically maintaining a tooth with an endodontic lesion that cannot be resolved by conventional endodontic (re-) treatment. To achieve this, continuous improvement in surgical techniques, materials and instruments is being done to enhance the outcome of periapical endodontic surgeries. The purpose of this study was to compare, radiographically, the healing kinetics of platelet-rich fibrin (PRF) and mineralized freeze-dried bone allograft (FDBA) in patients undergoing apicoectomy.

Materials and Methods:

Nineteen patients (aged 18–40 years) were included in the study and randomly assigned to groups A or B, where they received PRF or FDBA, respectively. Following apicoectomy, PRF gel and FDBA graft were prepared and placed in the osseous defect followed by placement of PRF membrane for graft stabilization and flap closure. Radiographic follow-up was done at the 1st, 3rd, 6th and 12th months for evaluation of healing using Molven's criteria. Statistical analysis was done with Pearson's and McNemar's Chi-square tests.

Results:

A highly significant difference (P = 0.002) in radiographic healing was observed at 6 months. Complete healing was observed in 50% of cases in Group A whereas in Group B, none of the cases presented with complete radiographic healing. However, at the end of 12 months, complete radiographic healing was observed in both groups.

Conclusion:

Our data suggest that PRF accelerates bone healing as compared to FDBA and is both time and cost-efficient.