bluuebunny/crossref_metadata_2025 huggingface dataset:
Design & Development Of Nano Formulations Of Various Anti Arthritic Agents For Arthritis.
Authors: Patel Bhavna A
Published: July 2024

Zaltoprofen and Cataflam are the NSAIDs category of drugs which could be used for the Arthritis for pain management. These are COX2 inhibitors, basically interfere with the prostaglandin synthesis and thus are able to reduce the sensation of pain in joints.
CUSTOMER RETENTION STRATEGIES IN E-COMMERCE: INSIGHTS FROM PURCHASING INTENTION DATA
Authors: Reddy A. Yashwanth
Published: July 2024

E-commerce has witnessed exponential growth in recent years, becoming a dominant force in retail. However, with this growth comes intense competition, making customer retention a critical focus for e-commerce businesses. Retaining customers is not only cost-effective but also contributes significantly to long-term business success and profitability. The concept of customer retention has been integral to business strategies across various industries for centuries. The challenge lies in developing effective customer retention strategies tailored to the unique dynamics of e-commerce. This requires a deep understanding of customer behavior, preferences, and purchasing intentions. Analyzing purchasing intention data provides valuable insights that can inform targeted strategies to keep customers engaged and loyal.
Planificación urbana metropolitana y problemática ambiental en territorios hidrosociales.
Authors: Vera Paula , Añaños María Celina , Ocantos Ariel
Published: July 2024

El objetivo del trabajo, de naturaleza exploratoria, es indagar la dimensión socioambiental como uno de los ejes constitutivos de la problemática urbana del Área Metropolitana de Rosario (AMR) afectada por la existencia de la infraestructura Hidrovía Paraguay-Paraná y cómo esta dimensión es abordada desde la planificación urbana a cargo del Ente de Coordinación Metropolitana (ECOM) y objeto de acciones de movimientos ambientalistas. La metodología es cualitativa basada en el análisis de fuentes documentales oficiales, entrevistas y observación de campo. La información analizada permite saber que entre los problemas se destacan: vulnerabilidad ambiental, deficiencias en la prestación de servicios, extensión desmedida y dispersa de la urbanización, desmoronamiento de barrancas, carencia de espacios públicos y ausencia de equipamientos, entre otros. Los instrumentos de planificación actuales los incorporan en forma muy general y se constata una carencia de acciones propositivas. Para su resolución se enfrentan dificultades por ausencia de soporte legal de la planificación metropolitana y estudios de impacto ambiental. En cuanto a la relación institucional entre organismos gubernamentales y movimientos sociales, esta es prácticamente inexistente.Temática que incorporamos en la agenda de investigación hacia el futuro.
Generating Descriptive Text From Images - Image Caption Generator
Authors: Avdhi Pagariya  , Riddhi Jain
Published: July 2024

In the modern era, image captioning has become one of the most widely required tools. Moreover, there are inbuilt applications that generate and provide a caption for a certain image, all these things are done with the help of deep neural network models. The process of generating a description of an image is called image captioning. It requires recognizing the important objects, their attributes, and the relationships among the objects in an image. It generates syntactically and semantically correct sentences. In this paper, we present a deep learning model to describe images and generate captions using computer vision and machine translation. This paper aims to detect different objects found in an image, recognize the relationships between those objects and generate captions. The dataset used is Flickr8k and the programming language used was Python3, and an ML technique called Transfer Learning will be implemented with the help of the caption model, to demonstrate the proposed experiment. This paper will also elaborate on the functions and structure of the various Neural networks involved. Generating image captions is an important aspect of Computer Vision and Natural language processing. Image caption generators can find applications in Image segmentation as used by Facebook and Google Photos, and even more so, its use can be extended to video frames. They will easily automate the job of a person who has to interpret images. Not to mention it has immense scope in helping visually impaired people
Formulation and Evaluation of Diuretic Activity of Polyherbal Drug in Rats
Authors: Archana Ingle  , Sourabh Jain  , Ragini Bundela  , Dr. Karunakar Shukla  , Dr. Rakesh Patel  , Prajakta Shelke Maskawade
Published: July 2024

An attempt was made in this study to investigate the diuretic activity of an ethanolic extract of a polyherbal formulation containing four drugs: seeds of Coriandrum sativum, buds of Syzigiumaromaticum, leaves of Ocimum sanctum, and curcumin (Curcuma longa), as well as leaves of Syzigiumaromaticum. According to the findings of this investigation, the extract of a polyherbal formulation (including seeds of Coriandrum sativum, buds and leaves of Syzigiumaromaticum& leaves of Ocimum sanctum, and Curcuma longa) possessed substantial activity. Various quantities of Polyherbal formulations (200 and 400 mg/kg), furosemide (10 mg/kg), and vehicle were given orally to rats (n = 6 animals per group), and the urine output was collected after 24 hours. All concentrations of Polyherbal formulation exhibited a dose-dependent relationship when compared to the control animals in the study. According to the findings of this study, the Polyherbal formulations have significant diuretic effect in rats when tested in the above-mentioned experimental model. That polyherbal formulation extract has such potent effect may be due to their ability to stimulate the excretion of Na+, K+, and Cl- concentrations in urine while also increasing the amount of urine excreted by the body. As diuretics, medicinal herbs are a key source of supply. When it comes to diuretics, both mono- and poly-herbal formulations have been employed successfully
Probebaya: Sinergi Masyarakat Dalam Pembangunan dan Pemberdayaan Masyarakat Kota Samarinda
Authors: Sultan Muhammad
Published: July 2024

Probebaya merupakan program pembangunan berbasis masyarakat yang digagas Pemerintah Kota Samarinda sejak tahun 2021. Penelitian ini bertujuan untuk mengeksplorasi kolaborasi antar unsur masyarakat dalam menyukseskan program Probebaya di Kota Samarinda. Penelitian dilaksanakan dengan desain eksplorasi yang melibatkan pengurus RT dan kelompok masyarakat sebagai informan. Data dikumpulkan secara langsung melalui triangulasi yang menggabungkan hasil wawancara, observasi lapangan, dan studi literatur. Data yang terkumpul dianalisis secara kualitatif. Hasil penelitian menunjukkan bahwa terjalin kolaborasi antara RT, kelompok masyarakat yang terdiri dari unsur masyarakat seperti tokoh masyarakat, dan masyarakat setempat sehingga program Probebaya di Kota Samarinda berjalan cukup baik. Disarankan penelitian lebih lanjut mengenai studi evaluasi Probebaya di Kota Samarinda agar dalam pelaksanaannya lebih optimal.
Implementasi Perpres Nomor 55 Tahun 2019 Tentang Percepatan Program Kendaraan Bermotor Listrik Berbasis Baterai (Battery Electric Vehicle) Untuk Transportasi Jalan Di Kota Singkawang
Authors: Aviani Nawang
Published: July 2024

Penelitian bertujuan untuk menganalisis Implementasi Perpres No. 55 Thn 2019 Tentang Percepatan Program Kendaraan Bermotor Listrik berbasis Baterai (Battery Electric Vehicle) untuk Transportasi Jalan.  Kendaraan  Bermotor  Listrik  Berbasis Baterai (KBLBB). Untuk mendukung penggunaan kendaraan listrik maka dibutuhkan sarana dan prasarana yang memadai sesuai dengan ketentuan mengoperasionalkan kendaraan listrik. Peneliti  menggunakan pendekatan deskriptif kualitatif dengan teknik pengumpulan data melalui observasi, dokumentasi, dan wawancara mendalam. Untuk observasi lapangan ke beberapa infrastruktur penunjang kendaraan listrik seperti SPKLU. Sedangkan untuk mengetahui implementasi oleh semua stakeholder menggunakan pedoman wawancara. Hasil dari penelitian ini Pemda Kota Singkawang sangat mendukung Program Percepatan ekosistem kendaraan listrik di Kota Singkawang, hanya saja program ini belum menjadi program prioritas pembangunan di Kota Singkawang sehingga ekosistem belum terbentuk dengan baik
¿Se puede hablar de ética del mercado?
Authors: Camacho Laraña Ildefonso
Published: July 2024

No abstract available.
Realidad Empresarial No. 18, 2024: 4-6.
Yenidoğanlarda Tanılama
Authors: İNAL Sevil , KIZILKAYA Tuba
Published: July 2024

Yenidoğanın tanılanması; yenidoğanın sağlık düzeyinin belirlenmesi, hastalıkların tedavi ve bakım sürecinin başlatılması için ilk basamaktır. Yenidoğanın tanılanmasında doğum öncesi öykü, obstetrik öykü, tıbbi öykü, aile öyküsü ve bebeğin öyküsü yer alır. Yenidoğanın tanılanmasında bebeğin fizik muayenesi sırasında sistemlere özel değerlendirme yapılır. Ebelik bakımının geliştirilmesinde detaylı bir anamnez alınması ve tanılama yapılması oldukça önemlidir. Bu bölümde yenidoğanın özellikleri, öykü alma süreci ve fiziksel değerlendirme basamakları açıklanmıştır.
Bariyatrik ve Metabolik Cerrahide Biyokimyasal Belirteçler
Authors: UZUN Hafize
Published: July 2024

Morbid obezite (MO), sıklıkla tip 2 diabetes mellitus, hipertansiyon, dislipidemi, obstrüktif uyku apne sendromu ve non-alkolik yağlı karaciğer gibi komorbiditelerle ilişkilidir. Obezite, hastalıkların ilerlemesi için değiştirilebilir bir risk faktörüdür. Bariyatrik cerrahi (BC), morbid obeziteyi tersine çevirmek ve komorbiditeleri iyileştirmek için en etkili tedavi yöntemidir. Post-op kilo kaybının, böbrek fonksiyonu, kardiyovasküler komplikasyonlar başta olmak üzere obezite ile ilişkili hastalıkların seyrini iyileştirmede, metabolik belirteçler üzerine olumlu etkileri vardır. BC, MO hastalarda önceki diyabet durumundan bağımsız olarak glukoz, insülin, HbA1c, HOMA-IR, sistolik kan basıncı, inflamasyon ve pıhtılaşma parametrelerinde azalma ile kardiyovasküler risk endekslerini, stabil, kilosu uyumlu deneklerden oluşan bir popülasyonla karşılaştırılabilir düzeye geri çevirir. Metabolik sendromun klasik belirteçlerinin yanı sıra hepatik ve pankreatik stresle ilişkili mikroRNA'larda düzelme sağlandı. MO ve buna bağlı hastalıklar, seçilmiş hastalarda cerrahi bir yaklaşımdan fayda görebilir. MO nedeniyle cerrahi olarak tedavi edilen hastaların yaşam boyu takibinde, besin alımının yeterliliği ve eksiksiz seri laboratuvar ölçümleri her zaman dahil edilmelidir.
Sleeve Gastrektomi Revizyonları
Authors: TÜRKÇAPAR Ahmet Gökhan
Published: July 2024

Obezite cerrahisinde, Laparoskopik Sleeve gastrektomi başlangıçta tahmin edilemeyecek düzeyde yaygınlaşarak en çok yapılan ameliyat haline gelmiştir. Kolay uygulanabirliği ve öğrenme eğrisinin düşüklüğü bu alanda uğraşan cerrah sayısının hızla artmasına yol açmıştır. Bu gelişme diğer taraftan cerrahi komplikasyonların başta kaçak ve darlıklar olmak üzere yeni bir sorun alanı haline getirmiştir. Sleeve sonrası geri kilo alımlarının yüksekliği ikincil müdahalelerin sayısının gelecektede artacağını göstermektedir. Cerrahların yeni tanıştıkları, bazılarının zaman alıcı ve çoklu müdahalelerle düzelebilen komplikasyonlar konusunda bilgilenmeleri ve revizyon cerrahisi tekniklerini öğrenmeleri oldukça önemlidir
Larenksin Enfeksiyonel Hastalıkları
Authors: BATIOĞLU KARAALTIN Ayşegül , KARA PEKER Sinem
Published: July 2024

Larenksin enfeksiyöz hastalıkları, sıklıkla viral etiyolojiler olmak üzere bakteryel ve fungal sebeplerle de oluşabilir. Disfoniden disfajiye kadar değişik yelpazelerde kendini gösteren bu hastalıklar rutin kulak burun boğaz kliniğinde sık rastlanılan hastalıklardan biri olarak kısaca “larenjit” olarak isimlendirilirler. Viral etkenlerden en sık görülenleri influenza, rinovirüs ve parainfluenza olmakla birlikte, bakteryel etkenler arasında Haemophılus influenza, Streptococcus ve Staphylococcus türleri yer almaktadır.Fungal enfeksiyonlar genellikle immün yetmezlikli hastalarda görülmekle birlikte en sık etken Candida’dır. Larenjitlerin tedavisi ise etkene göre farklılık göstermektedir.
Vokal Kord Paralizileri
Authors: BATIOĞLU KARAALTIN Ayşegül , GÜLMEZ Züleyha Dilek
Published: July 2024

Vokal kord paralizisi, ses, solunum, yutma ve vücut stabilizasyonunda zorluklara neden olan bir durumdur. Bu paralizi, superior laringeal sinir (SLS) ve/veya inferior laringeal sinir (rekürren laryngeal sinir-RLS) tam denervasyonunu ifade eder. Fonasyon sırasında hareket kaybına yol açan durumlar olarak, vokal kord paralizileri santral ve periferik nedenlere bağlı olarak ortaya çıkabilir. Cerrahi, neoplastik, travmatik, kardiyovasküler, dejeneratif hastalıklar gibi çeşitli faktörlere bağlı olarak etiyoloji oluşturabilir. Vokal kord paralizileri, lezyonun yerine, oluşum zamanına, vasküler, enfeksiyöz, neoplastik, travmatik nedenlere göre sınıflandırılabilir. Ses paternleri, superior larengeal sinir (SLS) veya inferior larengeal sinir (RLS) paralizisi durumuna göre farklılık gösterir. Santral paraliziler için her iki kortikal bölgenin hasar görmesi gereklidir. Periferik paralizilerde ise etkilenen taraftaki kaslar paralitik olduğu için hastalarda çeşitli ses ve solunum problemleri ortaya çıkar. Unilateral abdüktör paralizi, posterior krikoaritenoid kasın paralizisiyle karakterizedir ve sesin kullanılması ile yorulma tarzında disfonik özelliklere neden olabilir. Unilateral addüktör paralizi, hastalarda belirgin aspirasyon ve nefesli ses, hatta disfoni ve afoniye yol açabilir. Bilateral abdüktör paralizi genellikle iatrojenik sinir hasarı sonucu gelişir ve dispne, stridor gibi semptomlara neden olabilir. Bilateral addüktör paralizi, vokal kordların lateral pozisyonda kalmasına ve belirgin aspirasyona yol açabilir. Vokal kord paralizisinin tanısı, anamnez, fiziki muayene ve nörolojik muayene ile başlar. Laringoskopi ve videolaringostroboskopi ile vokal kordların pozisyonu, vibrasyonu, mukozal dalga hareketleri ve fonasyon esnasındaki aktiviteleri değerlendirilir. Elektroglottografi ile vokal kord teması, açılma ve kapanma fazları incelenir. Radyolojik incelemeler (akciğer grafisi, boyun-toraks BT, MR, tiroid usg) sinir hasarına neden olabilecek patolojileri belirlemeye yardımcı olur. Laringeal EMG, paralitik kas fonksiyonunu değerlendirmede kullanılır. Tedavi, paralizin durumuna ve hastanın etkilenme derecesine bağlı olarak belirlenir. İlk olarak, acil bir durum olup olmadığı değerlendirilmelidir. Spontan iyileşme süreci 1 yıla kadar görülebileceği için, kalıcı cerrahi müdahale öncesinde beklemek faydalı olabilir. Rekürren larengeal sinir hasarı, solunum, fonasyon, öksürme ve yutma fonksiyonlarını etkileyebilir. Sesini profesyonel olarak kullananlarda, ses frekansında kayma, ses ranjında azalma, perde artışında zorluk gibi etkiler gözlemlenebilir. Bu durumdaki hastalara özellikle ses terapisi önerilir. Terapi sürecinde hastanın sesi çeşitli ölçeklerle değerlendirilir ve aerodinamik değerlendirmeler yapılır. Ayrıca, hastalar ses kaynaklı duygusal ve psikolojik sorunlar yaşayabileceği için psikolojik destek de önemli bir yönü oluşturabilir
Kronik Otitis Media Komplikasyonları
Authors: ÇAKAN Doğan , ÇAM Özge Nur
Published: July 2024

Kronik otitis media (KOM), orta kulak yapılarının en az 3 ay boyunca devam eden inflamasyonu ile karakterize kronik bir hastalıktır. Orta kulakta sınırlı kalabileceği gibi iç ve dış kulağa da yayılabilir. KOM orta kulak ve temporal kemik havalı boşlukları dışına sirayet eder ise komplikasyonlar ortaya çıkar. Bu komplikasyonların tanınması ve yönetimi hayati öneme sahiptir
Next-Generation strategies to combat antimicrobial resistance: Integrating genomics, CRISPR, and novel therapeutics for effective treatment
Authors: Aliu Olalekan Olatunji  , Janet Aderonke Olaboye  , Chukwudi Cosmos Maha  , Tolulope Olagoke Kolawole  , Samira Abdul
Published: July 2024

Antimicrobial resistance (AMR) poses a significant threat to global public health, necessitating innovative strategies to combat this escalating issue. This review outlines next-generation approaches integrating genomics, CRISPR technology, and novel therapeutics to effectively address AMR. Genomic techniques enable comprehensive understanding of the genetic mechanisms underpinning resistance, facilitating the development of targeted interventions. By sequencing the genomes of resistant pathogens, researchers can identify resistance genes, track their spread, and predict emerging resistance patterns. CRISPR-Cas systems offer a revolutionary tool for combating AMR through precise genome editing. This technology can disrupt resistance genes, restore antibiotic sensitivity, and develop bacteriophage therapies that selectively target resistant bacteria. Moreover, CRISPR-based diagnostics enable rapid, accurate detection of resistant strains, enhancing infection control measures. The advent of novel therapeutics, such as antimicrobial peptides, bacteriophage therapy, and synthetic biology-derived compounds, provides alternative treatment options. These therapeutics can bypass traditional resistance mechanisms and exhibit efficacy against multi-drug resistant organisms. Additionally, integrating artificial intelligence (AI) and machine learning with genomics and CRISPR can accelerate the discovery of new antibiotics and predict resistance trends, optimizing treatment regimens. Implementing these next-generation strategies requires robust global collaboration, regulatory frameworks, and investment in research and development. By combining genomics, CRISPR, and novel therapeutics, we can create a multifaceted approach to overcome AMR, ensuring effective treatments and safeguarding public health. This integration represents a paradigm shift in antimicrobial strategy, offering hope for a future where resistant infections can be effectively managed and treated.
Keywords: Integrating Genomics, Antimicrobial Resistance, CRISPR, Therapeutic
Systematic review of the economic impacts of bioenergy on agricultural markets
Authors: Jephta Mensah Kwakye  , Darlington Eze Ekechukwu  , Olorunshogo Benjamin Ogundipe
Published: July 2024

This systematic review examines the economic impacts of bioenergy on agricultural markets, synthesising findings from existing literature across various regions and climatic conditions. Analysing effects on crop prices, land use decisions, and economic sustainability, the review highlights key insights. It identifies common trends, patterns, and divergences. Bioenergy production interacts with agricultural markets through multiple channels, influenced by policy interventions, technological innovation, and market dynamics. Implications for policy, practice, and future research are discussed, emphasising the importance of considering economic factors in bioenergy development and agricultural policy-making. The findings underscore the need for integrated modeling approaches, data improvements, and cross-sectoral collaboration to inform evidence-based decision-making and promote sustainable bioenergy development.
Keywords: Bioenergy, Agricultural Markets, Economic Impacts, Crop Prices, Land Use Decisions, Sustainability.
Mauprat de George Sand : un conte écologique ? Pour une lecture écopoétique du chapitre IV
Authors: Peuple Adrien
Published: July 2024

Chapter IV of the novel Mauprat distinguishes itself by an ecopoetic dimension aimed at denouncing Bernard de Mauprat’s ecological crime through the murder of the Patience’s owl. To this end, Sand uses the poetic codes of the fairy tale as literary material to sensitize the reader to Bernard's reprehensible crime. Indeed, Sand uses the topical motif of the punishment scene, inflicted on the tale's heroes by a sorcerer or fairy, to inscribe a didactic message in favour of respect for animals and environment. She also uses the terrifying setting of the wood to offer an eye-opening experience that invites Bernard to discover the supernatural powers of nature and become aware of its smallness. Thenceforth, the punishment scene is transformed into an ontological experience that leads the story to rediscover the origins of myth through the folkloric motifs of the tale. This aesthetic experience responds to Jean-Christophe Cavallinés recent ecopoetic vow: the ecology of story aims to return to an archaic world, reconnecting the human to the environment.
Littérature et nature : pour une approche dictionnairique
Authors: Chométy Philippe , Lamy Jérôme
Published: July 2024

The notion of “lit&nature” makes it possible to bring to light an international corpus of hybrid texts with an uncertain and poorly identified status, neither truly “scientific” nor truly “literary”, which bear the mark of a tension between two modes of knowledge of nature. Taking note of the main difficulties which still prevent the development of a general critical method which allows us to think about this tension, the authors of the Dictionnaire de litt&nature (to be published by Classiques Garnier in 2025) propose to contribute, with a group of authors, to the effort to theorize the inscription of natural knowledge in literature. The genre of the dictionary is particularly suitable for this.
Analisis Faktor yang Memberi Dampak pada Nilai Perusahaan
Authors: Prasetyoningsih Endah , Suryandani Wulan
Published: July 2024

Nilai suatu bisnis dapat diperlihatkan melalui harga saham yang dibuat di pasar modal dari pemesanan dan penawaran. Studi ini memiliki kegunaan untuk memperlihatkan bagaimana profitabilitas, likuiditas, leverage, dan ukuran suatu perusahaan berdampak pada nilainya pada perusahaan yang tergabung di BEI dalam industri makanan dan minuman. Perusahaan sektor makanan dan minuman yang tergabung di BEI selama dari tahun 2018 hingga 2022 adalah populasi yang digunakan dalam studi ini. Data yang didokumentasikan dalam studi ini dikumpulkan melalui metode pengambilan kriteria-kriteria tertentu. Tujuh perusahaan terlibat sebagai sampel selama lima tahun penelitian, dan mereka menghasilkan total 35 observasi yang dapat dikatakan bahwa data yang digunakan merupakan data sekunder. Data dipelajari melalui analisis regresi linear berganda. Studi ini memiliki temuan yang masing-masing memberi dampak pada nilai perusahaan yaitu; profitabilitas memberikan dampak positif signifikan, likuiditas memberi negatif signifikan, leverage memberi dampak negatif tidak signifikan dan ukuran perusahaan memberi dampak positif tidak signifikan. Selanjutnya temuan dari hasil pengujian determinasi menunjukkan bahwa seluruh variabel bebas yang diteliti hanya memiliki cakupan penjelasan sebanyak 7,9% pada variabel dependen yaitu nilai perusahaan, sisanya diterangkan oleh penyebab lain diluar fokus tujuan penelitian.
Tópicos em ciências da saúde: contribuições, desafios e possibilidades
Authors: Aires Caio Augusto Martins , Carvalho Francisco Sérvulo de Oliveira , Andrade Neto Francisco Vicente de , Souza Lara Michelly Soares de
Published: July 2024

É com grande entusiasmo que apresentamos o quarto volume desta bem-sucedida coletânea de estudos intitulada “Tópicos em ciências da saúde: contribuições, desafios e possibilidades”. Nesta edição, selecionamos artigos, revisões, relatos de caso ou experiência de relevância científica no amplo panorama das Ciências da Saúde. Seguindo o alto padrão dos volumes anteriores, os capítulos foram rigorosamente selecionados e avaliados quanto à robustez teórica, metodologias empregadas e resultados apresentados. Desse modo, oferecemos aos leitores uma visão abrangente e atualizada das contribuições científicas, dos desafios e das promissoras perspectivas que permeiam este campo crucial para o bem-estar humano. Esta obra destina-se a estudantes, profissionais e pesquisadores das áreas da saúde e afins que buscam se aprofundar nas contribuições, desafios e possibilidades das Ciências da Saúde. Reúne capítulos escritos por especialistas, pesquisadores e profissionais da saúde de diversas áreas, proporcionando uma visão multidisciplinar que converge para uma compreensão ampliada e crítica das complexas nuances deste campo dinâmico que é a saúde.
An interlaboratory comparison to quantify oxidative potential measurement in aerosol particles: challenges and recommendations for harmonisation
Authors: Dominutti Pamela A. , Jaffrezo Jean-Luc , Marsal Anouk , Mhadhbi Takoua , Elazzouzi Rhabira , Rak Camille , Cavalli Fabrizia , Putaud Jean-Philippe , Bougiatioti Aikaterini , Mihalopoulos Nikolaos , Paraskevopoulou Despina , Mudway Ian S. , Nenes Athanasios , Daellenbach Kaspar R. , Banach Catherine , Campbell Steven J. , Cigánková Hana , Contini Daniele , Evans Greg , Georgopoulou Maria , Ghanem Manuella , Glencross Drew A. , Guascito Maria Rachele , Herrmann Hartmut , Iram Saima , Jovanović Maja , Jovašević-Stojanović Milena , Kalberer Markus , Kooter Ingeborg M. , Paulson Suzanne E. , Patel Anil , Perdrix Esperanza , Pietrogrande Maria Chiara , Mikuška Pavel , Sauvain Jean-Jacques , Seitanidi Aikaterina , Shahpoury Pourya , Souza Eduardo J. S. , Steimer Sarah , Stevanovic Svetlana , Suarez Guillaume , Subramanian P. S. Ganesh , Utinger Battist , van Os Marloes F. , Verma Vishal , Wang Xing , Weber Rodney J. , Yang Yuhan , Querol Xavier , Hoek Gerard , Harrison Roy M. , Uzu Gaëlle
Published: July 2024

Abstract. This paper presents the findings from a collaborative interlaboratory comparison exercise designed to assess oxidative potential (OP) measurements conducted by 20 laboratories worldwide. This study represents an innovative effort as the first exercise specifically aimed at harmonising this type of OP assay, setting a new benchmark in the field. Over the last decade, there has been a noticeable increase in OP studies, with numerous research groups investigating the effects of exposure to air pollution particles through the evaluation of OP levels. However, the absence of standardised methods for OP measurements has resulted in variability in results across different groups, rendering meaningful comparisons challenging. To address this issue, this study engages in an international effort to compare OP measurements using a simplified method (with a dithiothreitol (DTT) assay). Here, we quantify the OP in liquid samples to focus on the protocol measurement itself, while future ILCs should aim to assess the full-chain process, including the sample extraction. We analyse the similarities and discrepancies observed in the results, identifying the critical parameters (such as the instrument used, the use of a simplified protocol, the delivery and analysis time) that could influence OP measurements, and provide recommendations for future studies and interlaboratory comparisons. Even if other crucial aspects, such as sampling PM methods, sample storage, extraction methods and conditions, and the evaluation of other OP assays, still need to be standardised. This collaborative approach enhances the robustness of the OP-DTT assay and paves the way for future studies to build on a unified framework. This pioneering work concludes that interlaboratory comparisons provide essential insights into the OP metric and are crucial to move toward the harmonisation of OP measurements.
Ionospheric upwelling and the level of associated noise at solar minimum
Authors: David Timothy Wemimo , Michael Chizurumoke Michael , Wright Darren , Talabi Adetoro Temitope , Ajetunmobi Abayomi Ekundayo
Published: July 2024

Abstract. We have studied the ionospheric upwelling with a magnitude of above 1013 m−2 s−1 using the data during the European Incoherent Scatter Scientific Association (EISCAT) Svalbard Radar International Polar Year (IPY-ESR) 2007 campaign, which coincides with the solar minimum. The noise level in low-, medium- and high-flux upflows is investigated. We found that the noise level in high-flux upflow is about 93 %, while in the low and medium categories it is 62 % and 80 %, respectively. This shows that robust and stringent filtering techniques must be ensured when analysing incoherent data in order not to introduce bias to the result. Analysis reveals that the frequency of the low-flux upflow events is about 8 and 73 times the medium- and high-flux upflow events, respectively. Seasonal observation shows that the noise level in the upflow classes is predominantly high during winter. The noise is minimal in summer, with a notable result indicating occurrence of actual data above noise in the low-flux class. Moreover, the percentage occurrence of the noise level in the data increases with increasing flux strength, irrespective of the season. Further analysis reveals that the noise level in the local time variation peaked around 17:00–18:00 LT (local time) and minimum around 12:00 LT.
On crustal composition of the Sardinia-Corsica continental block inferred from receiver functions
Authors: Cammarano Fabio , Roisenberg Henrique Berger , Conclave Alessio , Fadel Islam , van der Meijde Mark
Published: July 2024

Abstract. Subduction-related geodynamic processes significantly influence plate tectonics and Earth’s evolution, yet their impact on the continental crust remains poorly understood. We investigated the Sardinia-Corsica continental block, situated in the Mediterranean Sea, which has experienced intense subduction-driven geodynamic events. By analyzing P-wave receiver functions from our LiSard seismic network and publicly available stations, we aimed to understand crustal structure and composition. We inferred the Moho depth and examined the P-wave to S-wave velocity ratio (VP /VS ). We interpret our findings considering petrological data, heat flux measurements, and other geophysical information. We found that the Variscan granitoid batholith has the greatest Moho depths in both Sardinia and Corsica. VP /VS ratios (ranging from 1.65 to 1.70) are consistent with average crustal values of SiO2 between 65 % and 70 %. However, in central Corsica, two stations have exceptionally high VP /VS values (>1.80), suggesting the possible presence of serpentinite throughout the crust. In Alpine Corsica, a station exhibited similar high VP /VS values but a shallower Moho depth of 21 km. The western part of Sardinia, where Cenozoic volcanism occurred, also showed a shallower Moho depth (20–25 km) and high VP /VS values. The highest VP /VS value (1.91) is recorded in an area where surface-wave dispersion curves from ambient noise identified the lowest average S-wave velocity and where the highest heat flux has been reported, indicating elevated crustal temperatures and possible presence of melt within the crust. Overall, our results indicate that the recent geodynamic processes have left the granitoid batholith almost intact, with minimal alteration to its composition.
Causes of the exceptionally high number of fatalities in the Ahr valley, Germany, during the 2021 flood
Authors: Rhein Belinda , Kreibich Heidi
Published: July 2024

Abstract. Over the last 40 years (1980–2020), 159 people have died in inland floods in Germany. The flood of 2021 caused 190 flood fatalities in Germany, 134 of them in the Ahr valley. We investigate what made this event so 'deadly' in order to help improve flood risk management and prevent future fatalities. A comprehensive analysis of the factors influencing the occurrence of fatalities is carried out on the basis of the death investigation files of the public prosecutor's office. This unprecedented flash flood was characterised by high water levels and high flow velocities. The extent of inundation in 2021 far exceeded the official hazard map for the extreme flood scenario. Additionally, early warning and evacuation were inadequate so that many people were surprised by the flash flood. 75 % of the fatalities occurred outside of the mapped hazard zones. Particularly dangerous places were campsites, cellars and basement flats, but many people died on the ground floor (37 %) or outside on the street (18 %). The elderly above 60 years of age (78 %) and those with mobility or cognitive impairments (16 %) were particularly vulnerable. No gender-specific differences in vulnerability were observed. Public understanding of the particular danger posed by flash floods must be improved, as must the development and presentation of worst-case scenarios in hazard maps. Additionally, impact forecasting can significantly improve emergency management of such unprecedented floods. Specific recommendations are that in the event of such extreme flash floods, the warning messages must clearly communicate that saving human lives must be the priority, i.e., those at risk should move to safe places, e.g., to the upper floors. Evacuations must be initiated in good time, especially where flooding of the ground floor with high water levels is to be expected, paying particular attention to the safety of the elderly and people with limited mobility.
Modeled Greenland Ice Sheet evolution constrained by ice-core-derived Holocene elevation histories
Authors: Lauritzen Mikkel Langgaard , Solgaard Anne Munck , Rathmann Nicholas Mossor , Vinther Bo Møllesøe , Grindsted Aslak , Noël Brice , Aðalgeirsdóttir Guðfinna , Hvidberg Christine Schøtt
Published: July 2024

Abstract. During the Holocene, the Greenland Ice Sheet (GrIS) experienced substantial thinning, with some regions losing up to 600 meters of ice. Ice sheet reconstructions, paleoclimatic records, and geological evidence indicate that during the Last Glacial Maximum, the GrIS extended far beyond its current boundaries and was connected with the Innuitian Ice Sheet (IIS) in the northwest. We investigate these long-term geometry changes and explore several possible factors driving those changes by using the Parallel Ice Sheet Model (PISM) to simulate the GrIS thinning throughout the Holocene period, from 11.7 ka ago to the present. We perform an ensemble study of 841 model simulations in which key model parameters are systematically varied to determine the parameter values that, with quantified uncertainties, best reproduce the 11.7 ka of surface elevation records derived from ice cores, providing confidence in the modeled GrIS historical evolution. We find that since the Holocene onset, 11.7 ka ago, the GrIS mass loss has contributed 5.3±0.3 m to the mean global sea level rise, which is consistent with the ice-core-derived thinning curves spanning the time when the GrIS and the Innuitian Ice Sheet were bridged. Our results suggest that the ice bridge collapsed 4.9±0.5 ka ago and that the GrIS is still responding to these past changes today, having raised sea level by 23±26 mm SLE ka-1 in the last 500 years. Our results have implications for future mass-loss projections, which should account for this long-term, transient trend.
A New High-Resolution Multi-Drought Indices Dataset for Mainland China
Authors: Zhang Qi , Miao Chiyuan , Su Jiajia , Gou Jiaojiao , Hu Jinlong , Zhao Xi , Xu Ye
Published: July 2024

Abstract. Drought indices are crucial for assessing and managing water scarcity and agricultural risks; however, the lack of a unified data foundation in existing datasets leads to inconsistencies that challenge the comparability of drought indices. This study is dedicated to creating CHM_Drought, an innovative and comprehensive long-term meteorological drought dataset with a spatial resolution of 0.1° and data collected from 1961 to 2022 in mainland China. It features six pivotal meteorological drought indices: the standardized precipitation index (SPI), standardized precipitation evapotranspiration index (SPEI), evaporative demand drought index (EDDI), Palmer drought severity index (PDSI), self-calibrating Palmer drought severity index (SC-PDSI), and vapor pressure deficit (VPD), of which SPI, SPEI, and EDDI contain multi-scale features for periods of 2 weeks and 1–12 months. The dataset features a comprehensive application of high-density meteorological station data and a complete framework starting from basic meteorological elements (the China Hydro-Meteorology dataset, CHM). Demonstrating its robustness, the dataset excels in accurately capturing drought events across mainland China, as evidenced by its detailed depiction of the 2022 summer drought in the Yangtze River basin. In addition, to evaluate CHM_Drought, we performed consistency tests with the drought indices calculated based on Climatic Research Unit (CRU) and CN05.1 data and found that all indices had high consistency overall and that the 2-week scale SPI, SPEI, and EDDI had potential early warning roles in drought monitoring. Overall, our dataset bridges the gap in high-precision multi-index drought data in China, and the complete CHM-based framework ensures the consistency and reliability of the dataset, which contributes to enhancing the understanding of drought patterns and trends in China. Free access to the dataset can be found at https://doi.org/10.6084/m9.figshare.25656951.v2 (Zhang and Miao, 2024).
A glacial lake outburst flood risk assessment for the Phochhu river basin, Bhutan
Authors: Wangchuk Tandin , Tsubaki Ryota
Published: July 2024

Abstract. The melting of glaciers has led to an unprecedented increase in the number and size of glacial lakes, particularly in the Himalayan region. A glacial lake outburst flood (GLOF) is a natural hazard in which water from a glacial or glacier-fed lake is swiftly discharged. GLOFs can significantly harm life, infrastructure, and settlements located downstream and can have considerable ecological, economic, and social impacts. Based on a dam breach model, BREACH, and a hydrodynamic model, HEC-RAS (Hydrologic Engineering Centre's River Analysis System), we examined the potential consequences of a GLOF originating from the Thorthomi glacial lake, located within the Phochhu river basin, one of Bhutan's largest and rapidly expanding glacial lakes. Our analysis revealed that following a breach the Thorthomi glacial lake will likely discharge a peak flow of 16 360 m3 s−1 within 4 h. Such a discharge could potentially cause considerable damage, with an estimated 245 ha of agricultural land and over 1277 buildings at risk of inundation. To mitigate ecological, economic, and social impacts on downstream areas, our results emphasise an urgent need for understanding and preparing for the potential consequences of a GLOF from Thorthomi lake. Our findings provide valuable insights for policymakers and stakeholders involved in disaster management and preparedness.
On the influence of cross-sectional deformations on the aerodynamic performance of wind turbine rotor blades
Authors: Gebauer Julia Sabrina , Prigge Felix Konstantin , Ahrens Dominik , Wein Lars , Balzani Claudio
Published: July 2024

Abstract. The aerodynamic performance of a wind turbine rotor blade depends on the geometry of the used airfoils. The airfoil shape can be affected by elastic deformations of the blade during operation due to structural loads. This paper provides an initial estimation of the extent to which cross-sectional deformations influence the aerodynamic load distribution along the rotor blade. The IEA 15 MW reference wind turbine model is used for this study. A constant wind field at the rated wind speed is applied as a test case. The resulting loads are calculated by an aero-servo-elastic simulation of the turbine. The loads are applied to a 3D finite element (FE) model of the rotor blade, which serves to calculate the cross-sectional deformations. For the individual cross-sections in the deformed configuration, the new lift and drag coefficients are calculated. These are then included in the aero-servo-elastic simulation and the obtained results are compared with those of the initial simulation that is based on the undeformed cross-sections. The cross-sectional deformations consist of a change in the chord length and the geometry of the trailing edge panels and depend largely on the azimuth position of the blade. The change in the airfoil geometries results in altered aerodynamic characteristics and therefore in a deviation of the blade root bending moments, the maximum change of which is -1.4 % in the in-plane direction and +0.71 % in the out-of-plane direction. Although these values are relatively small, the initial results imply that further investigations should be carried out with more complex wind fields and different rotor blade designs to identify aero-structural couplings that may be critical for the design of rotor blades or other wind turbine components.
Design of a Solar Tracker for Monitoring Smart Farming Hydroponics Based on the Internet of Things
Authors: Rosita Isa , Sufiana Sufiana , Safii Muhammad
Published: July 2024

The use of Internet of Things (IoT) technology in agriculture is growing rapidly. One of the IoT technologies that can be utilized in agriculture is smart farming. Smart farming is an agricultural method that uses information and communication technology to increase productivity and efficiency in the agricultural sector, one of which is hydroponics. Hydroponics is a farming technique without using soil media, which uses water as a medium for plant growth. However, in the application of smart farming Hydroponics, some obstacles still need to be overcome. One of these obstacles is plant monitoring which is still done manually, requiring a lot of time and effort. In addition, energy use is also a problem in smart farming Hydroponics applications. One solution to these obstacles is using a solar tracker to monitor smart farming hydroponics. A solar tracker is a technology used to follow the movement of the sun to increase energy efficiency. By using a solar tracker, maximum energy can be generated, so that it can be used for monitoring smart farming hydroponics.
Meta-Analysis of the Effectiveness of Sofosbuvir-Based Regimens in Treating Hepatitis C Genotype 3
Authors: Siddique Hafsa , Tariq Syed Sufyan , Asghar Syed Parvez , Fahim Muhammad Faisal
Published: July 2024

Hepatitis C virus (HCV) is an RNA virus with seven primary genotypes. It is highly prevalent in Pakistan, especially genotype 3. HCV infection can progress to a chronic state with further complications. Direct-acting antiviral agents (DAAV) were introduced in 2014 as a treatment option, some of which include Sofosbuvir (SOF), Daclatasvir (DCV), Velpatasvir (VEL) and Ribavirin (RV). This meta-analysis was performed to outline the treatment response and efficacy of DAAV in HCV infected patients.
 
We systematically searched PubMed, Web of Science, MEDLINE, and Google Scholar for studies from January 2019 to December 2023. The studies selected met the criteria of patients having chronic HCV infection (genotype 3) and either compensated cirrhosis or decompensated chronic liver disease. Treatment regimens with DAAV specifically were included. The primary outcomes [sustained viral response (SVR), rapid virological response (RVR), end-of-treatment response (ETR)] were highlighted to assess treatment response.
 
The studies proved that the use of direct-acting antiviral agents in different combinations was very effective against HCV infection with minimal side-effects.
Occupational culture, accommodation, and decision-making: South-East Queensland child protection worker perspectives
Authors:   , Mathieson Brenna
Published: July 2024

The challenge of understanding occupational culture and its influence on decision making is explored in this thesis, through the lens of Professional Accommodation Syndrome. Using a qualitative study, the project gained the unique perspectives of former child safety officers to help understand the influence of occupational culture on both decision-making processes and outcomes. In expanding the Professional Accommodation framework, the project found that occupational culture does influence child protection and subsequently decision-making, leading to decisions that are either too risk averse, too risk tolerant, or not sufficiently child focused. This knowledge seeks to improve working environments for child protection workers.
Arraigo y reescritura de la obra de Àngel Guimerà en el teatro, la prensa y el cine de la República Argentina
Authors: Martori Joan
Published: July 2024

Durante el largo periodo comprendido entre 1894 y 1972 la obra teatral de Àngel Guimerà contó con una notable difusión en la escena, la prensa y las pantallas de la República Argentina. Además de su implementación, en este artículo se exponen varios ejemplos de las transformaciones que se llevaron a cabo a partir de Terra baixa y de su reutilización con fines diversos en el contexto político y social de Argentina. Buenos Aires, metrópoli cultural de Latinoamérica, actuó como el crisol en el que se fundieron las vías americana y europea de internacionalización de la obra de mayor expansión del teatro clásico catalán.
Green Hydrogen from Hydroelectric Energy: Assessing the Potential at the Abanico Power Plant in Morona Santiago Province
Authors: A. Barragán-Escandón  , S. Arostegui Gutiérrez  , E. Zalamea-Leon  , X. Serrano-Guerrero
Published: July 2024

A key strategy for optimizing the utilization of clean energy sources involves integrating energy vectors to effectively manage surplus power generated from renewable sources. This study specifically delves into the assessment of a hydrogen (H₂) generation project utilizing energy generated by the Hidroabanico power plant. Over a span of 13 years, the average monthly energy production was meticulously scrutinized, with a determination that 20% of this energy would be allocated for H₂ production. The operational framework of the prototype plant, which relies on Proton Exchange Membrane (PEM) electrolyser technology, is comprehensively elucidated. This system boasts an annual energy capacity capable of reaching 62,439 MWh (20% of total production), culminating in the production of 1,123 Tn of H₂. However, it is noteworthy that this quantity remains relatively limited compared to analyses conducted utilizing alternative technologies.
Metodologia de regionalização com vistas ao desenvolvimento do raciocínio geográfico
Authors: Melilo Carrieri Raquel Augusta , De Oliveira Roque Ascenção Valéria
Published: July 2024

A região, para a Geografia, é um termo permeado de dissensos. O ensino de Geografia não resolve isso e nem traz consensos. Mas pode operar numa outra lógica ao permitir que o conceito seja um instrumento para a construção de novas aprendizagens. Partindo dessa consideração teve-se como objetivo geral o desenvolvimento de uma metodologia de regionalização ancorada em pressupostos do Conhecimento Pedagógico do Conteúdo (PCK), que proporcione a mobilização de ações do raciocínio geográfico. Articulando os conteúdos pedagógicos gerais e o conhecimento do conteúdo de Geografia, foi desenvolvida uma metodologia de regionalização enquanto exercício didático. Acredita-se que o exercício criado pode mobilizar ações mentais próprias do raciocínio geográfico, com o destaque para a diferenciação, generalização e representação dos espaços. Além disso, entendeu-se que a metodologia de regionalização pode contribuir para o resgate da identidade da Geografia na escola por meio do seu estatuto epistemológico. Ao aprender uma técnica de divisão em regiões, os estudantes podem ampliar suas percepções do espaço e, por meio da interpretação dos mapas criados, pensar em novas situações geográficas.
10. ĐẶC ĐIỂM LÂM SÀNG VÀ VI KHUẨN TRONG VIÊM MŨI XOANG CẤP TÍNH Ở TRẺ EM TẠI BỆNH VIỆN SẢN NHI NGHỆ AN
Authors: Hải Tăng Xuân , Long Trần Minh , Tuấn Bùi Viết
Published: July 2024

Mục tiêu: Mô tả đặc điểm lâm sàng viêm mũi xoang cấp tính ở trẻ em; xác định một số vi khuẩn gây bệnh tại mũi xoang và mức độ nhạy cảm với kháng sinh của vi khuẩn trong viêm mũi xoang cấp ở trẻ em.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang 42 trẻ em được chẩn đoán viêm mũi xoang cấp theo Tiêu chuẩn của Hội Mũi Xoang châu Âu năm 2020 tại Khoa Tai Mũi Họng, Bệnh viện Sản Nhi Nghệ An từ tháng 3/2022 đến tháng 9/2022.
Kết quả: 95,2% bệnh nhân có triệu chứng chảy mũi. Hầu hết bệnh nhân có biểu hiện phù nề niêm mạc mũi, dịch mủ sàn mũi và dịch mủ ngách mũi giữa, trong đó mủ đặc trắng/vàng/xanh ở ngách mũi chiếm tỷ lệ cao nhất, một số trường hợp có mủ nhầy đục ở ngách mũi. Tỷ lệ nuôi cấy vi khuẩn mọc chiếm 54,8%. Tất cả các bệnh phẩm đều chỉ có 1 chủng vi khuẩn. 3 loài vi khuẩn hay gặp nhất là S. pneumonia, H. influenza và M. catarrhalis với tỷ lệ lần lượt là 65,2%; 17,4% và 13%. Với kháng sinh Amoxicillin + Axit Clavulanic, các vi khuẩn đều có sự nhạy cảm khá cao, từ 75-100%. Cefuroxime và Trimethoprim + Sulfamethoxazole có độ nhạy cảm thấp ở hầu hết các nhóm vi khuẩn.
Kết luận: Nuôi cấy định danh vi khuẩn trong viêm mũi xoang cấp tính ở trẻ em giúp cho bác sỹ lâm sàng định hướng sử dụng kháng sinh thích hợp để điều trị.