bluuebunny/crossref_metadata_2025 huggingface dataset:
Bit mapping for balanced PCM cell programming
Authors: Du Yu , Zhou Miao , Childers Bruce R. , Mossé Daniel , Melhem Rami
Published: July 2013

Write bandwidth is an inherent performance bottleneck for Phase Change Memory (PCM) for two reasons. First, PCM cells have long programming time, and second, only a limited number of PCM cells can be programmed concurrently due to programming current and write circuit constraints,

For each PCM write, the data bits of the write request are typically mapped to multiple cell groups and processed in parallel. We observed that an unbalanced distribution of modified data bits among cell groups significantly increases PCM write time and hurts effective write bandwidth. To address this issue, we first uncover the cyclical and cluster patterns for modified data bits. Next, we propose
double XOR mapping (D-XOR)
to distribute modified data bits among cell groups in a balanced way. D-XOR can reduce PCM write service time by 45% on average, which increases PCM write throughput by 1.8x. As error correction (redundant bits) is critical for PCM, we also consider the impact of redundancy information in mapping data and error correction bits to cell groups. Our techniques lead to a 51% average reduction in write service time for a PCM main memory with ECC, which increases IPC by 12%.
Tri-level-cell phase change memory
Authors: Seong Nak Hee , Yeo Sungkap , Lee Hsien-Hsin S.
Published: July 2013

There are several emerging memory technologies looming on the horizon to compensate the physical scaling challenges of DRAM. Phase change memory (PCM) is one such candidate proposed for being part of the main memory in computing systems. One salient feature of PCM is its multi-level-cell (MLC) property, which can be used to multiply the memory capacity at the cell level. However, due to the nature of PCM that the value written to the cell can drift over time, PCM is prone to a unique type of soft errors, posing a great challenge for their practical deployment. This paper first quantitatively studied the current art for MLC PCM in dealing with the resistance drift problem and showed that the previously proposed techniques such as scrubbing or error correction mechanisms have significant reliability challenges to overcome. We then propose tri-level-cell PCM and demonstrate its ability to achieving
10

5

x lower soft error rate than four-level-cell PCM and 1.33 x higher information density than single-level-cell PCM. According to our findings, the tri-level-cell PCM shows 36.4% performance improvement over the four-level-cell PCM while achieving the soft error rate of DRAM.
ZSim
Authors: Sanchez Daniel , Kozyrakis Christos
Published: July 2013

Architectural simulation is time-consuming, and the trend towards hundreds of cores is making sequential simulation even slower. Existing parallel simulation techniques either scale poorly due to excessive synchronization, or sacrifice accuracy by allowing event reordering and using simplistic contention models. As a result, most researchers use sequential simulators and model small-scale systems with 16-32 cores. With 100-core chips already available, developing simulators that scale to thousands of cores is crucial.

We present three novel techniques that, together, make thousand-core simulation practical. First, we speed up detailed core models (including OOO cores) with instruction-driven timing models that leverage dynamic binary translation. Second, we introduce bound-weave, a two-phase parallelization technique that scales parallel simulation on multicore hosts efficiently with minimal loss of accuracy. Third, we implement lightweight user-level virtualization to support complex workloads, including multiprogrammed, client-server, and managed-runtime applications, without the need for full-system simulation, sidestepping the lack of scalable OSs and ISAs that support thousands of cores.

We use these techniques to build zsim, a fast, scalable, and accurate simulator. On a 16-core host, zsim models a 1024-core chip at speeds of up to 1,500 MIPS using simple cores and up to 300 MIPS using detailed OOO cores, 2-3 orders of magnitude faster than existing parallel simulators. Simulator performance scales well with both the number of modeled cores and the number of host cores. We validate zsim against a real Westmere system on a wide variety of workloads, and find performance and microarchitectural events to be within a narrow range of the real system.
GPUWattch
Authors: Leng Jingwen , Hetherington Tayler , ElTantawy Ahmed , Gilani Syed , Kim Nam Sung , Aamodt Tor M. , Reddi Vijay Janapa
Published: July 2013

General-purpose GPUs (GPGPUs) are becoming prevalent in mainstream computing, and performance per watt has emerged as a more crucial evaluation metric than peak performance. As such, GPU architects require robust tools that will enable them to quickly explore new ways to optimize GPGPUs for energy efficiency. We propose a new GPGPU power model that is configurable, capable of cycle-level calculations, and carefully validated against real hardware measurements. To achieve configurability, we use a bottom-up methodology and abstract parameters from the microarchitectural components as the model's inputs. We developed a rigorous suite of 80 microbenchmarks that we use to bound any modeling uncertainties and inaccuracies. The power model is comprehensively validated against measurements of two commercially available GPUs, and the measured error is within 9.9% and 13.4% for the two target GPUs (GTX 480 and Quadro FX5600). The model also accurately tracks the power consumption trend over time. We integrated the power model with the cycle-level simulator GPGPU-Sim and demonstrate the energy savings by utilizing dynamic voltage and frequency scaling (DVFS) and clock gating. Traditional DVFS reduces GPU energy consumption by 14.4% by leveraging within-kernel runtime variations. More finer-grained SM cluster-level DVFS improves the energy savings from 6.6% to 13.6% for those benchmarks that show clustered execution behavior. We also show that clock gating inactive lanes during divergence reduces dynamic power by 11.2%.
Studying multicore processor scaling via reuse distance analysis
Authors: Wu Meng-Ju , Zhao Minshu , Yeung Donald
Published: July 2013

The trend for multicore processors is towards increasing numbers of cores, with 100s of cores--
i.e
. large-scale chip multiprocessors (LCMPs)--possible in the future. The key to realizing the potential of LCMPs is the cache hierarchy, so studying how memory performance will scale is crucial. Reuse distance (RD) analysis can help architects do this. In particular, recent work has developed
concurrent reuse distance (CRD)
and
private reuse distance (PRD)
profiles to enable analysis of shared and private caches. Also, techniques have been developed to predict profiles across problem size and core count, enabling the analysis of configurations that are too large to simulate.

This paper applies RD analysis to study the scalability of multicore cache hierarchies. We present a framework based on CRD and PRD profiles for reasoning about the locality impact of core count and problem scaling. We find
interference-based
locality degradation is more significant than
sharing-based
locality degradation. For 256 cores running small problems, the former occurs at small cache sizes, allowing moderate capacity scaling of multicore caches to achieve the same cache performance (MPKI) as a single-core cache. At very large problems, interference-based locality degradation increases significantly in many of our benchmarks. For shared caches, this prevents most of our benchmarks from achieving constant-MPKI scaling within a 256 MB capacity budget; for private caches, all benchmarks cannot achieve constant-MPKI scaling within 256 MB.
Protozoa
Authors: Zhao Hongzhou , Shriraman Arrvindh , Kumar Snehasish , Dwarkadas Sandhya
Published: July 2013

State-of-the-art multiprocessor cache hierarchies propagate the use of a fixed granularity in the cache organization to the design of the coherence protocol. Unfortunately, the fixed granularity, generally chosen to match average spatial locality across a range of applications, not only results in wasted bandwidth to serve an individual thread's access needs, but also results in unnecessary coherence traffic for shared data. The additional bandwidth has a direct impact on both the scalability of parallel applications and overall energy consumption.

In this paper, we present the design of Protozoa, a family of coherence protocols that eliminate unnecessary coherence traffic and match data movement to an application's spatial locality. Protozoa continues to maintain metadata at a conventional fixed cache line granularity while 1) supporting variable read and write caching granularity so that data transfer matches application spatial granularity, 2) invalidating at the granularity of the write miss request so that readers to disjoint data can co-exist with writers, and 3) potentially supporting multiple non-overlapping writers within the cache line, thereby avoiding the traditional ping-pong effect of both read-write and write-write false sharing. Our evaluation demonstrates that Protozoa consistently reduce miss rate and improve the fraction of transmitted data that is actually utilized.
Design space exploration and optimization of path oblivious RAM in secure processors
Authors: Ren Ling , Yu Xiangyao , Fletcher Christopher W. , van Dijk Marten , Devadas Srinivas
Published: July 2013

Keeping user data private is a huge problem both in cloud computing and computation outsourcing. One paradigm to achieve data privacy is to use tamper-resistant processors, inside which users' private data is decrypted and computed upon. These processors need to interact with untrusted external memory. Even if we encrypt all data that leaves the trusted processor, however, the address sequence that goes off-chip may still leak information. To prevent this address leakage, the security community has proposed ORAM (Oblivious RAM). ORAM has mainly been explored in server/file settings which assume a vastly different computation model than secure processors. Not surprisingly, naïvely applying ORAM to a secure processor setting incurs large performance overheads.

In this paper, a recent proposal called Path ORAM is studied. We demonstrate techniques to make Path ORAM practical in a secure processor setting. We introduce background eviction schemes to prevent Path ORAM failure and allow for a performance-driven design space exploration. We propose a concept called super blocks to further improve Path ORAM's performance, and also show an efficient integrity verification scheme for Path ORAM. With our optimizations, Path ORAM overhead drops by 41.8%, and SPEC benchmark execution time improves by 52.4% in relation to a baseline configuration. Our work can be used to improve the security level of previous secure processors.
SurfNoC
Authors: Wassel Hassan M. G. , Gao Ying , Oberg Jason K. , Huffmire Ted , Kastner Ryan , Chong Frederic T. , Sherwood Timothy
Published: July 2013

As multicore processors find increasing adoption in domains such as aerospace and medical devices where failures have the potential to be catastrophic, strong performance isolation and security become first-class design constraints. When cores are used to run separate pieces of the system, strong time and space partitioning can help provide such guarantees. However, as the number of partitions or the asymmetry in partition bandwidth allocations grows, the additional latency incurred by time multiplexing the network can significantly impact performance.

In this paper, we introduce SurfNoC, an on-chip network that significantly reduces the latency incurred by temporal partitioning. By carefully scheduling the network into waves that flow across the interconnect, data from different domains carried by these waves are strictly non-interfering while avoiding the significant overheads associated with cycle-by-cycle time multiplexing. We describe the scheduling policy and router microarchitecture changes required, and evaluate the information-flow security of a synthesizable implementation through gate-level information flow analysis. When comparing our approach for varying numbers of domains and network sizes, we find that in many cases SurfNoC can reduce the latency overhead of implementing cycle-level non-interference by up to 85%.
Non-race concurrency bug detection through order-sensitive critical sections
Authors: Huang Ruirui , Halberg Erik , Suh G. Edward
Published: July 2013

This paper introduces a new heuristic condition for non-race concurrency bugs, named order-sensitive critical sections, and proposes a run-time bug detection scheme based on the condition. The order-sensitive critical sections are defined as a pair of critical sections that can lead to non-deterministic shared memory state depending on the order in which they execute. In a sense, the order-sensitive critical sections can be seen as extending the intuition in using data races as a potential bug condition to capture non-race bugs. Experiments show that the proposed scheme provides a good coverage for multiple types of non-race bugs, with a small number of false positives. For example, the scheme detected all 9 real-world non-race bugs that were tested as well as over 90% of injected non-race bugs. Additionally, this paper presents an efficient hardware architecture that supports the proposed scheme with minor hardware changes and a small amount of additional state - a 9-KB buffer per core and a 1-bit tag per data cache block. The hardware-based scheme could still detect all 9 real-world bugs that were tested and more than 84% of the injected non-race bugs. Moreover, the hardware supported scheme has a negligible impact on performance, with a 0.23% slowdown on average.
11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action
Authors: Chapman Karen , Holmes Megan , Seckl Jonathan
Published: July 2013

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyze interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone. 11β-HSD type 1, a predominant reductase in most intact cells, catalyzes the regeneration of active glucocorticoids, thus amplifying cellular action. 11β-HSD1 is widely expressed in liver, adipose tissue, muscle, pancreatic islets, adult brain, inflammatory cells, and gonads. 11β-HSD1 is selectively elevated in adipose tissue in obesity where it contributes to metabolic complications. Similarly, 11β-HSD1 is elevated in the ageing brain where it exacerbates glucocorticoid-associated cognitive decline. Deficiency or selective inhibition of 11β-HSD1 improves multiple metabolic syndrome parameters in rodent models and human clinical trials and similarly improves cognitive function with ageing. The efficacy of inhibitors in human therapy remains unclear. 11β-HSD2 is a high-affinity dehydrogenase that inactivates glucocorticoids. In the distal nephron, 11β-HSD2 ensures that only aldosterone is an agonist at mineralocorticoid receptors (MR). 11β-HSD2 inhibition or genetic deficiency causes apparent mineralocorticoid excess and hypertension due to inappropriate glucocorticoid activation of renal MR. The placenta and fetus also highly express 11β-HSD2 which, by inactivating glucocorticoids, prevents premature maturation of fetal tissues and consequent developmental “programming.” The role of 11β-HSD2 as a marker of programming is being explored. The 11β-HSDs thus illuminate the emerging biology of intracrine control, afford important insights into human pathogenesis, and offer new tissue-restricted therapeutic avenues.
Frictional Effects on Gear Tooth Contact Analysis
Authors: Li Zheng , Mao Ken
Published: July 2013

The present paper concentrates on the investigations regarding the situations of frictional shear stress of gear teeth and the relevant frictional effects on bending stresses and transmission error in gear meshing. Sliding friction is one of the major reasons causing gear failure and vibration; the adequate consideration of frictional effects is essential for understanding gear contact behavior accurately. An analysis of tooth frictional effect on gear performance in spur gear is presented using finite element method. Nonlinear finite element model for gear tooth contact with rolling/sliding is then developed. The contact zones for multiple tooth pairs are identified and the associated integration situation is derived. The illustrated bending stress and transmission error results with static and dynamic boundary conditions indicate the significant effects due to the sliding friction between the surfaces of contacted gear teeth, and the friction effect can not be ignored. To understand the particular static and dynamic frictional effects on gear tooth contact analysis, some significant phenomena of gained results will also be discussed. The potentially significant contribution of tooth frictional shear stress is presented, particularly in the case of gear tooth contact analysis with both static and dynamic boundary conditions.
Splitting of a Dexamethasone Implant (Ozurdex) following the Injection
Authors: Donmez Oya , Parlak Melih , Yaman Aylin , Saatci Ali Osman
Published: July 2013

In this brief report, we share our observations on a splitted Dexamethasone implant (Ozurdex) which we discovered a week after the injection. It is likely that implant splitting neither changes the efficacy of the implant nor creates a mishap for the patient.
Short-Term Photochemical and Biological Unreactivity of Macrophyte-Derived Dissolved Organic Matter in a Subtropical Shallow Lake
Authors: They Ng Haig , Marques David Motta , Souza Rafael Siqueira , Ribeiro Rodrigues Lúcia
Published: July 2013

Macrophytes have been associated with low bacterial metabolism in the littoral zones of lake Mangueira, but an explanation for this pattern is largely unknown. In this study, macrophyte-derived DOM was incubated in situ for the measurement of the effect of grazers, bacteria, and light on its degradation in three experiments. The water was separated in bulk, bacterial, and control (+ HgCl2) fractions and exposed to or hidden from sunlight for 120 h. Unchange in bacterial variables in the bulk fraction suggested a combined control of radiation and grazing on bacteria. Light treatment increased bacterial density but not biomass and biovolume, while bacterial density decreased in the dark. Significant fading of water color in the bacterial fraction only occurred after light exposure, indicating a complementary pathway of light and bacteria. DOC and the Abs250 : 365 ratio did not change with incubation, indicating no net change of DOC pool and reactivity. Due to continuous carbon loading from macrophytes and low UV irradiance, the very low rates of DOM degradation provide the mechanistic explanation for the observed impacts of macrophytes in lake’s carbon metabolism in littoral zones.
Spiculated Bladder Calculi: The Culprit for Repeated Catheter Failure
Authors: Wek C. , Fox T. P. , Muir G. H.
Published: July 2013

We report on the case of a frustrated 90-year-old gentleman who was seen in the Accident and Emergency department for the third time in four days with failure of his long-term urethral catheter. He reported that the catheter simply “fell out” with the balloon deflated. On each occasion previously, the catheter had been reinserted in A&E and the patient discharged home. These repeated visits to A&E were understandably a source of much frustration for the patient and his family. On the third presentation, plain abdominal radiography demonstrated a large spiculated bladder calculus.
Interesting Activities Discovery for Moving Objects Based on Collaborative Filtering
Authors: Yuan Guan , Xia Shixiong , Zhang Yanmei
Published: July 2013

With the development of location-based service, more and more moving objects can be traced, and a great deal of trajectory data can be collected. Finding and studying the interesting activities of moving objects from these data can help to learn their behavior very well. Therefore, a method of interesting activities discovery based on collaborative filtering is proposed in this paper. First, the interesting degree of the objects' activities is calculated comprehensively. Then, combined with the newly proposed hybrid collaborative filtering, similar objects can be computed and all kinds of interesting activities can be discovered. Finally, potential activities are recommended according to their similar objects. The experimental results show that the method is effective and efficient in finding objects' interesting activities.
Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery
Authors: Lekhanont Kaevalin , Jongkhajornpong Passara , Choubtum Lulin , Chuckpaiwong Varintorn
Published: July 2013

The purpose of this study was to investigate the efficacy and safety of topical 100% serum eye drops for corneal epithelial defect after ocular surgery. A total of 181 patients who received topical 100% serum therapy for the treatment of corneal epithelial defect following several different types of ocular surgery were recruited into this study. Each patient already failed conventional medical therapy before being prescribed 100% serum eye drops. Slit-lamp biomicroscopic examination with fluorescein staining was performed at baseline and all follow-up visits. The main outcome measures were the rate of complete healing of the corneal epithelial defect and incidence of adverse events. One hundred and seventy-eight eyes (98.34%) received autologous serum eye drops, and 3 (1.66%) received allogeneic serum eye drops. The overall success rate of treating persistent postoperative epithelial defect using 100% serum eye drops was 93.92% (95% CI 0.88–0.98). The median time to complete corneal epithelialization was 4 days (95% CI 4-5). Adverse reactions were observed in 3 patients (1.66%), including sticky sensation with minimal eye discomfort and asymptomatic trace corneal subepithelial infiltration. No serious complications were reported. In conclusion, 100% serum eye drops are effective, safe, and tolerable for treating postoperative corneal epithelial defect following ocular surgeries.
Polaronic Mechanism of Superconductivity in Cuprates
Authors: Chaudhary Pradeep , Nuwal Anuj , Tiwari S. C. , Paliwal R. K. , Kakani S. L.
Published: July 2013

A strong polaron pairing model of high-temperature cuprate superconductors is presented. The normal and anomalous one-particle Green’s functions are derived from a system with strong electron-phonon coupling. Self-consistent equation for the superconducting order parameter (Δ) is derived using Green’s function technique and following Lang and Firsov transformations. Expressions for specific heat, density of states, free energy, and critical field based on this model have been derived. The theory is applied to explain the experimental results in the system YBa2Cu3O7-x. There is convincing evidence that the theory is fully compatible with the key experiments.
Innovative Radiating Systems for Train Localization in Interference Conditions
Authors: Vegni C. , Tosti M. , Vegni A. M.
Published: July 2013

The design of innovative radiating systems based on the metamaterial technology for GNSS (Global Navigation Satellite System) applications in radio frequency (RF) interference conditions is proposed. To this aim, firstly two typical adaptive array techniques (i.e.,nullingandbeam-forming) are discussed and tradeed off. Secondly, FRPA (Fixed Radiation Pattern Antenna) and CRPA (Controlled Radiation Pattern Antenna) phased array configurations of miniaturized patch antennas are studied by means of electromagnetic commercial tools and phased array optimization algorithms. This process leads to the identification of a phased array design. Benefits and drawbacks for GNSS applications are highlighted. Finally, the design of the phased array is applied to a GNSS user receiver in a navigation realistic environment. Simulation results are obtained in a realistic scenario for railway applications, comprising of a GNSS satellite constellation, a GNSS user receiver (i.e., on-board train equipment) running along a track in Western Australia, and a constellation of interfering satellites. Navigation service performances (i.e., user location accuracy and service availability) are computed taking into account the adaptive array radiation pattern in two different modes (i.e., FRPA or CRPA) and band-limited white noise interference.
A Rare Complication of an Ingested Foreign Body: Gallbladder Perforation
Authors: Karacay Safak , Topçu Koray , Sözübir Selami
Published: July 2013

We present a 13-year-old child who admitted with a dull right upper quadrant pain that started 3 weeks before her referral. Several medications were given but they did not change the intensity and the frequency of the pain. Her physical examination was nonspecific except for slight right upper quadrant tenderness. The imaging studies revealed a sewing pin perforating the stomach and gallbladder. The patient was treated with a successful operation, and no postoperative complications were observed. To our knowledge, this is the first case of a sharp foreign body gallbladder perforation in a child.
CuO and Co3O4 Nanoparticles: Synthesis, Characterizations, and Raman Spectroscopy
Authors: Rashad M. , Rüsing M. , Berth G. , Lischka K. , Pawlis A.
Published: July 2013

Copper oxide and cobalt oxide (CuO, Co3O4) nanocrystals (NCs) have been successfully prepared in a short time using microwave irradiation without any postannealing treatment. Both kinds of nanocrystals (NCs) have been prepared using copper nitrate and cobalt nitrate as the starting materials and distilled water as the solvent. The resulted powders of nanocrystals (NCs) were characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM) measurements. The obtained results confirm the presence of the both of oxides nanopowders produced during chemical precipitation using microwave irradiation. A strong emission under UV excitation is obtained from the prepared CuO and Co3O4 nanoparticles. The results show that the nanoparticles have high dispersion and narrow size distribution. The line scans of atomic force microscopy (AFM) images of the nanocrystals (NCs) sprayed on GaAs substrates confirm the results of both X‐ray diffraction and transmission electron microscopy. Furthermore, vibrational studies have been carried out using Raman spectroscopic technique. Specific Raman peaks have been observed in the CuO and Co3O4 nanostructures, and the full width at half maximum (FWHM) of the peaks indicates a small particle size of the nanocrystals.
EMQP: An Energy-Efficient Privacy-Preserving MAX/MIN Query Processing in Tiered Wireless Sensor Networks
Authors: Dai Hua , Yang Geng , Qin Xiaolin
Published: July 2013

We consider a hybrid two-tiered sensor network consisting of regular resource-limited sensor nodes and powerful master nodes with abundant resources. In the architecture, master nodes take charge of storing data collected by sensor nodes and processing queries from the base station. Due to the important role of master nodes, they might easily become the target for the adversary to compromise in an untrusted or hostile circumstance. A compromised master node may leak sensitive data in its storage to the adversary, which breaches the data privacy. This paper proposes EMQP, a novel and energy-efficient privacy-preserving MAX/MIN query protocol which is capable of preventing adversaries from obtaining sensitive data collected by sensor nodes. To preserve privacy, the 0-1 encoding verification, keyed-hash message authentication coding, and symmetric encryption are applied to achieve the secret comparison of data items without knowing their real values. On the basis of secret comparison mechanism, the data submission and query processing protocols are proposed to describe the details of EMQP. And the analyses on privacy protection and energy consumption are also given. Moreover, a hash-based optimization method is presented to save more energy of the resource-limited sensor nodes. The simulation result shows that EMQP is more efficient than the current work in energy consumption.
Some Haematological and Biochemical Investigations on Duck Virus Hepatitis following Administration of Glycyrrhizin
Authors: Okda Faten A. , Yassein Safaa , Ahmed Alaa R. , Soufy Hamdy , Nasr Soad M.
Published: July 2013

The present study aimed to investigate the protective effect of glycyrrhizin (locally isolated and purified from licorice root) against duck hepatitis virus through the assessment of some hematological and biochemical parameters. One hundred and sixty white Pekin ducklings—one day old—were randomly divided into four equal groups. Group (1) was kept as normal control. Group (2) was inoculated I/P with 10 mg glycyrrhizin/kg BW, three times per week for four weeks. Group (3) was inoculated I/M with 0.5 ml of live attenuated DHV vaccine. Group (4) was inoculated with both glycyrrhizin (10 mg/kg BW I/P, three times per week for four weeks) and live attenuated DHV vaccine (0.5 ml, I/M). Then, all groups of treatment were challenged using virulent DHV except for 20 ducklings from the normal control group which were continued to be kept as negative control. The results revealed that duck hepatitis virus (DHV) caused macrocytic hypochromic anemia, leukopenia, hypoproteinemia, hypoalbuminemia, hyperglycemia, hypercholesterolemia, and marked elevation of liver enzymes and renal parameters. In conclusion, glycyrrhizin injected alone or in combination with DHV vaccine protected or ameliorated the deteriorating effects induced by DHV vaccine and/or duck hepatitis virus infection by improvement of erythrogram and leukogram, as well as liver and kidney functions.
Global Stability Analysis and Optimal Control of a Harvested Ecoepidemiological Prey Predator Model with Vaccination and Taxation
Authors: Liu Chao , Zhang Qingling , Li Jinna
Published: July 2013

We propose an ecoepidemiological prey predator model, where selective harvest effort on predator population is considered. Vaccination and taxation are introduced as control instruments, which are utilized to control number of susceptible prey population and protect predator population from overexploitation, respectively. Conditions which influence nonnegativity and boundedness of solutions are studied. Global stability analysis around disease-free equilibrium is discussed based on robust Bendixson criterion, which is theoretically beneficial to studying coexistence and interaction mechanism of population within harvested ecoepidemiological system. By using Pontryagin’s maximum principle, an optimal control strategy is derived to maximize the total discounted net economic revenue to society as well as protect prey population from infectious disease. Numerical simulations are carried out to show the consistency with theoretical analysis.
Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer
Authors: Li Bo , Simon M. Celeste
Published: July 2013

MYC is a multifunctional transcription factor that is deregulated in many human cancers. MYC impacts a collaborative genetic program that orchestrates cell proliferation, metabolism, and stress responses. Although the progression of MYC-amplified tumors shows robust dependence on MYC activity, directly targeting MYC as a therapeutic method has proven to be technically difficult. Therefore, alternative approaches are currently under development with a focus on interference with MYC-mediated downstream effects. To fuel rapid cell growth, MYC reprograms cancer cell metabolism in a way that is substantially different from normal cells. The MYC-induced metabolic signature is characterized by enhanced glucose and glutamine uptake, increased lactate production, and altered amino acid metabolism. Targeting MYC-reprogrammed cancer cell metabolism is considered to be promising based on multiple preclinical studies. In addition, the increased biosynthetic demand of MYC-driven tumors coupled with limited nutrient access within tumor microenvironments create multiple levels of oncogenic stress, which can also be used as tumor-specific targets for pharmacologic intervention. Presumably, the best therapeutic strategy for treating MYC-amplified tumors is combined targeting of multiple MYC-mediated pathways, especially those involved in regulating cell proliferation, metabolism, and oncogenic stress. Clin Cancer Res; 19(21); 5835–41. ©2013 AACR.
The Leptomeningeal Ivy Sign on Fluid-Attenuated Inversion Recovery Images in Moyamoya Disease: Positron Emission Tomography Study
Authors: Kaku Yasuyuki , Iihara Koji , Nakajima Norio , Kataoka Hiroharu , Fukushima Kazuhito , Iida Hidehiro , Hashimoto Nobuo
Published: July 2013

Background: The ivy sign is sometimes seen on fluid-attenuated inversion recovery (FLAIR) images in moyamoya disease (MMD). In recent studies using single-photon emission computed tomography, ivy sign proliferation correlated with decreases in cerebrovascular reserve. However, a decreased vascular reserve is not concrete. The purpose of this study was to evaluate the correlation between ivy sign proliferation and the findings of 15O gas positron emission tomography (PET). Methods: In 19 MMD patients (12 women, age 31-69 years) with ischemic symptoms, FLAIR magnetic resonance imaging and 15O gas PET were performed. We classified the middle cerebral artery (MCA) territory into 2 regions in each hemisphere, and the degree of the ivy sign (ivy sign score) in each region was classified into 3 grades (0-2), where grade 0 indicated an absence of the ivy sign, grade 1 indicated that the ivy sign was seen on less than half of the cortical surface in each region, and grade 2 indicated that the ivy sign was seen on more than half of the cortical surface. We examined the relationship among the ivy sign score, the severity of ischemic symptoms and PET parameters in 76 MCA regions of 19 patients. Results: Ivy sign scores of the regions were 0 (n = 19), 1 (n = 40), and 2 (n = 17). Total ivy sign score of a hemisphere increased as clinical symptoms became more severe. Cerebral blood flow (CBF) values were lower, cerebral blood volume (CBV) values were higher, and CBF/CBV values were lower than those of controls as symptoms became severe (p < 0.05). CBF and CBF/CBV values decreased and CBV values increased as the ivy sign score increased, and were significantly higher and lower, respectively, than control values (p < 0.05). No significant differences in cerebral metabolic rate of oxygen and oxygen extraction fraction were found between the 3 ivy sign scores. A positive correlation was found between ivy sign score and increases in CBV (p < 0.01), and a more obvious negative correlation was found between ivy sign score and decreases in CBF/CBV (p < 0.001). Conclusions: We evaluated the correlation between ivy sign proliferation and the findings of 15O gas PET. We suggested that ivy sign proliferation was associated with both dilated pial vasculature and the slow flow of developed leptomeningeal collaterals in patients with MMD.
Long-Term Outcome after Anticoagulation-Associated Intracerebral Haemorrhage with or without Restarting Antithrombotic Therapy
Authors: Gathier Celine S. , Algra Ale , Rinkel Gabriël J.E. , van der Worp H. Bart
Published: July 2013

Background: For patients who survive intracerebral haemorrhage (ICH) during treatment with oral anticoagulation (OAC), the balance between the benefits and risks of restarting OAC is unclear. The decision to restart OAC or to start antiplatelet therapy in these patients therefore poses a dilemma for all physicians involved. We assessed the long-term outcome of patients who did or did not restart antithrombotic therapy after OAC-associated ICH. Methods: We conducted a retrospective follow-up study of all patients discharged from our institution after OAC-associated ICH over a 10-year period. Data on the use of OAC or platelet inhibitors and the occurrence of vascular events during follow-up were assessed through questionnaires and patient files. The primary outcome was recurrent fatal or non-fatal stroke. Secondary outcomes were the occurrence of other haemorrhagic, thrombotic or thromboembolic events. With patients without antithrombotic treatment as reference, we calculated incidence ratios with corresponding 95% confidence intervals (CI) for treatment with OAC and for treatment with antiplatelet therapy. Results: We included 38 patients, of whom 21 (55%) died during a mean follow-up of 3.5 years. The medication regime changed frequently during follow-up, illustrated by the fact that two thirds of the patients who had resumed OAC within 2 months of ICH terminated this at later points in time. Two recurrent strokes occurred during 35.4 patient-years without antithrombotic medication, 7 during 63.8 patient-years on antiplatelet medication (incidence ratio 1.9; 95% CI, 0.4-9.4), and 3 during 19.5 patient-years on OAC (incidence ratio 2.7; 95% CI, 0.5-16.3). There was only 1 recurrent ICH, which occurred during treatment with OAC. Conclusion: In this observational study, no significant difference in the primary outcome measure was found between the treatment groups, but there was a tendency towards a higher long-term risk of any stroke in patients who resumed OAC or started antiplatelet therapy. However, based on these results it is difficult to draw any concrete conclusions or make any strong recommendations. A randomized trial to assess the optimal long-term strategy after OAC-related ICH is warranted. Based on the point estimates of our study, such a trial should involve at least 300 patient-years of follow-up.
Two new species of Paravelia Breddin, 1898 (Hemiptera: Heteroptera: Veliidae) from Colombia, with a key to Colombian Paravelia species
Authors: PADILLA-GIL DORA NANCY
Published: July 2013

Paravelia fanera sp. n. and Paravelia acantha sp. n. are described from the Andean region of Colombia. An identification key and distributional data for Colombian species are given.
Three new species from the Aoridae and Maeridae (Crustacea, Amphipoda) from Thai Waters
Authors: Wongkamhaeng Koraon , Coleman CharleS Oliver , Pholpunthin Pornsilp
Published: July 2013

Four species of amphipods from the families Aoridae and Maeridae were collected from Thai Waters in 2011. Three species, Grandidierella phetraensis sp. nov., Ceradocus andamanensis sp. nov. and Parelasmopus siamensis sp. nov. are new to science and Bemlos quadrimanus (Sivaprakasam, 1970) has not been previously reported from Thai Waters. Their characters are described and illustrated. All specimens are deposited at Princess Maha Chakri Sirindhorn Natural History Museum, Prince of Songkla University, Thailand and the Museum für Naturkunde, Berlin.
Reply to “Comments on ‘Current GCMs' Unrealistic Negative Feedback in the Arctic'”
Authors: Boé Julien , Hall Alex , Qu Xin
Published: July 2013

Pithan and Mauritsen argue that the 2009 results of Boé et al. are not consistent with current understanding of the lapse-rate feedback in the Arctic. They also argue that these results arise to an important extent from self-correlation issues. In this response, the authors argue that their results are not inconsistent with current understanding of lapse-rate feedback and demonstrate that the conclusions remain unchanged when all possibilities of self-correlation are excluded.
How Oceanic Oscillation Drives Soil Moisture Variations over Mainland Australia: An Analysis of 32 Years of Satellite Observations*
Authors: Bauer-Marschallinger Bernhard , Dorigo Wouter A. , Wagner Wolfgang , van Dijk Albert I. J. M.
Published: July 2013

Australia is frequently subject to droughts and floods. Its hydrology is strongly connected to oceanic and atmospheric oscillations (climate modes) such as the El Niño–Southern Oscillation (ENSO), Indian Ocean dipole (IOD), and southern annular mode (SAM). A global 32-yr dataset of remotely sensed surface soil moisture (SSM) was used to examine hydrological variations in mainland Australia for the period 1978–2010. Complex empirical orthogonal function (CEOF) analysis was applied to extract independent signals and to investigate their relationships to climate modes. The annual cycle signal represented 46.3% of the total variance and a low but highly significant connection with SAM was found. Two multiannual signals with a lesser share in total variance (6.3% and 4.2%) were identified. The first one had an unstable period of 2–5 yr and reflected an east–west pattern that can be associated with ENSO and SAM but not with IOD. The second one, a 1- to 5-yr oscillation, formed a dipole pattern between the west and north and can be linked to ENSO and IOD. As expected, relationships with ENSO were found throughout the year and are especially strong during southern spring and summer in the east and north. Somewhat unexpectedly, SAM impacts strongest in the north and east during summer and is proposed as the key driver of the annual SSM signal. The IOD explains SSM variations in the north, east, and southeast during spring and also in the west during winter.
Empirical Localization of Observation Impact in Ensemble Kalman Filters
Authors: Anderson Jeffrey , Lei Lili
Published: July 2013

Localization is a method for reducing the impact of sampling errors in ensemble Kalman filters. Here, the regression coefficient, or gain, relating ensemble increments for observed quantity y to increments for state variable x is multiplied by a real number α defined as a localization. Localization of the impact of observations on model state variables is required for good performance when applying ensemble data assimilation to large atmospheric and oceanic problems. Localization also improves performance in idealized low-order ensemble assimilation applications. An algorithm that computes localization from the output of an ensemble observing system simulation experiment (OSSE) is described. The algorithm produces localizations for sets of pairs of observations and state variables: for instance, all state variables that are between 300- and 400-km horizontal distance from an observation. The algorithm is applied in a low-order model to produce localizations from the output of an OSSE and the computed localizations are then used in a new OSSE. Results are compared to assimilations using tuned localizations that are approximately Gaussian functions of the distance between an observation and a state variable. In most cases, the empirically computed localizations produce the lowest root-mean-square errors in subsequent OSSEs. Localizations derived from OSSE output can provide guidance for localization in real assimilation experiments. Applying the algorithm in large geophysical applications may help to tune localization for improved ensemble filter performance.
Which MJO Events Affect North American Temperatures?
Authors: Schreck Carl J. , Cordeira Jason M. , Margolin David
Published: July 2013

Tropical convection from the Madden–Julian oscillation (MJO) excites and amplifies extratropical Rossby waves around the globe. This forcing is reflected in teleconnection patterns like the Pacific–North American (PNA) pattern, and it can ultimately result in temperature anomalies over North America. Previous studies have not explored whether the extratropical response might vary from one MJO event to another. This study proposes a new index, the multivariate PNA (MVP), to identify variations in the extratropical waveguide over the North Pacific and North America that might affect the response to the MJO. The MVP is the first combined EOF of 20–100-day OLR, 850-hPa streamfunction, and 200-hPa streamfunction over the North Pacific and North America. The North American temperature patterns that follow each phase of the MJO change with the sign of the MVP. For example, real-time multivariate MJO (RMM) phase 5 usually leads to warm anomalies over eastern North America. This relationship was only found when the MVP was negative, and it was not associated with El Niño or La Niña. RMM phase 8, on the other hand, usually leads to cold anomalies. Those anomalies only occur if the MVP is positive, which happens somewhat more frequently during La Niña years. Composite analyses based on combinations of the MJO and the MVP show that variability in the Pacific jet and its associated wave breaking play a key role in determining whether and how the MJO affects North American temperatures.
Tornado Probability of Detection and Lead Time as a Function of Convective Mode and Environmental Parameters
Authors: Brotzge Jerald A. , Nelson Steven E. , Thompson Richard L. , Smith Bryan T.
Published: July 2013

The ability to provide advanced warning on tornadoes can be impacted by variations in storm mode. This research evaluates 2 yr of National Weather Service (NWS) tornado warnings, verification reports, and radar-derived convective modes to appraise the ability of the NWS to warn across a variety of convective modes and environmental conditions. Several specific hypotheses are considered: (i) supercell morphologies are the easiest convective modes to warn for tornadoes and yield the greatest lead times, while tornadoes from more linear, nonsupercell convective modes, such as quasi-linear convective systems, are more difficult to warn for; (ii) parameters such as tornado distance from radar, population density, and tornado intensity (F scale) introduce significant and complex variability into warning statistics as a function of storm mode; and (iii) tornadoes from stronger storms, as measured by their mesocyclone strength (when present), convective available potential energy (CAPE), vertical wind shear, and significant tornado parameter (STP) are easier to warn for than tornadoes from weaker systems. Results confirmed these hypotheses. Supercell morphologies caused 97% of tornado fatalities, 96% of injuries, and 92% of damage during the study period. Tornado warnings for supercells had a statistically higher probability of detection (POD) and lead time than tornado warnings for nonsupercells; among supercell storms, tornadoes from supercells in lines were slightly more difficult to warn for than tornadoes from discrete or clusters of supercells. F-scale intensity and distance from radar had some impact on POD, with less impact on lead times. Higher mesocyclone strength (when applicable), CAPE, wind shear, and STP values were associated with greater tornado POD and lead times.
Genetic and Environmental Overlap Between Delinquent Peer Association and Delinquency in Adolescence
Authors: Boisvert Danielle , Boutwell Brian B. , Vaske Jamie , Newsome Jamie
Published: July 2013

Delinquent peer association and criminal/delinquent behaviors are highly intertwined. The directionality and mechanisms underlying this relationship, however, have been debated in the literature for decades. The current study seeks to further inform this debate by examining whether individual differences at the level of the genome can help to explain the association between delinquent peer affiliation and delinquency. Using the twin and full-sibling subsample from the National Longitudinal Study of Adolescent Health (Add Health), behavioral genetic methodology is used to examine whether delinquent peer affiliation and delinquency in adolescence covary as the result of common genetic factors. Results indicate that delinquent peer association and delinquency are moderately influenced by additive genetic factors, and that common genes are in fact influencing the covariance between the two outcomes. The importance of incorporating genetic explanations into traditional theories of delinquency is discussed.
Probable Cause and the Sniff Factor
Authors: Ross Darrell L.
Published: July 2013

The U.S. Supreme Court has previously rendered only three opinions regarding the use of drug-detecting dogs in formulating probable cause leading to a search. Yet, in their 2012–2013 term, they published two decisions on the constitutionality of using drug detection dogs, establishing probable cause, and performing searches. This article provides an assessment of the Court’s decisions in Florida v. Harris (2013) and Florida v. Jardines (2013) and addresses the implications of these decisions.