bluuebunny/crossref_metadata_2025 huggingface dataset:
HSV model based data hiding in video for watermark applications
Authors: Jerisha Liby J. , Jaya T
Published: June 2021

This manuscript proposes a new data hiding approach that is used in watermark applications in video by transforming the RGB model to HSV model. This method initially estimates the number of frames needed to embed the data (watermark). Then two sets of RGB (Red, Green, Blue) coefficients (R1, G1, B1), (R2, G2, B2) are converted to HSV (Hue, saturation, values) Coefficients (H1, S1, V1) and (H2, S2, V2). The ‘Value’ Coefficients V1 and V2 are used to embed the watermark, since there exists a strong correlation between the adjacent ‘Value’ Coefficients. The same process is repeated on adjacent HSV coefficients till the watermark is fully embedded. After embedding the data HSV coefficients are again converted back to RGB coefficients. During the extraction phase, the data is extracted by transforming the RGB coefficient to HSV coefficients. One bit of information can be extracted from two adjacent HSV coefficients. Experimental outcomes show that the proposed watermarking approach is efficiently against attacks, viz noise, filtering, etc. Also, the proposed method performs better than traditional watermarking methods with the help of embedding rate (bpp), Structural similarity index measurement (SSIM), Visual quality (PSNR), Normalized cross-correlation (NC).
Novel q-rung orthopair fuzzy interaction aggregation operators and their application to low-carbon green supply chain management
Authors: Riaz Muhammad , Garg Harish , Farid Hafiz Muhammad Athar , Aslam Muhammad
Published: June 2021

The low-carbon supply chain management is big a challenge for the researchers due to the rapid increase in global warming and environmental concerns. With the advancement of the environmental concerns and social economy, it is an unavoidable choice for a business to achieve sustainable growth for low-carbon supply chain management. Since the root of the chain depends upon the supplier selection and choosing an excellent low-carbon supply. Green supplier selection is one of the most crucial activities in low-carbon supply chain management, it is critical to develop rigorous requirements and a system for selection in low-carbon green supply chain management (LCGSCM). A q-rung orthopair fuzzy number (q-ROFN) is pair of membership degree (MD) and non-membership degrees (NMD) which is reliable to address uncertainties in the various real-life problems. This article sets out a decision analysis approach for interactions between MDs and NMDs with the help of q-ROFNs. For this objective, we develop new aggregation operators (AOs) named as, q-rung orthopair fuzzy interaction weighted averaging (q-ROFIWA) operator, q-rung orthopair fuzzy interaction ordered weighted averaging (q-ROFIOWA) operator, q-rung orthopair fuzzy interaction hybrid averaging (q-ROFIHA) operator, q-rung orthopair fuzzy interaction weighted geometric (q-ROFIWG) operator, q-rung orthopair fuzzy interaction ordered weighted geometric (q-ROFIOWG) operator and q-rung orthopair fuzzy interaction hybrid geometric (q-ROFIHG) operator. These AOs define an advanced approach for information fusion and modeling uncertainties in multi-criteria decision-making (MCDM). At the end, a robust MCDM approach based on newly developed AOs is developed. Some significant properties of these AOS are analyzed and the efficiency of the developed approach is assessed with a practical application towards sustainable low-carbon green supply chain management.
The application of computer-aided teaching in art teaching
Authors: Tang Hai
Published: June 2021

With the rapid development of information technology, information technology has become the main technology tool in education and teaching. Modern education and teaching must combine with information technology and give full play to the role of information technology in education and teaching. Art education is different from other subjects. Art education has its own characteristics. It is a comprehensive education and teaching system centered on aesthetics. It is one of the important measures to improve students’ comprehensive quality in modern teaching and is an important link of the development of quality education. Based on the background of informatization, this article uses VR technology to apply real experience and interactive “immersive teaching” to art teaching, and at the same time establishes an art teaching system, which realizes online learning, communication, counseling and other functions, reducing students’ knowledge threshold. It further explains the advantages and prominent role of computer-aided teaching in art teaching, and shows that computer-aided teaching should complement traditional teaching in art teaching and give full play to its active role.
Personalized dynamic evaluation technology of online education quality management based on artificial intelligence big data
Authors: Bai Xujing , Li Jiajun
Published: June 2021

Limited by the difficulty of management, the quality of online education is far worse than the quality of classroom teaching. In order to improve the effect of online education quality management, according to the actual needs of online teaching, this article builds personalized dynamic evaluation technology based on artificial intelligence big data technology and uses evaluation as the center of teaching. Each link in the teaching is for the generation and development of evaluation, and the teaching plan takes the learning objectives as the basis for the entire teaching process. Moreover, this research combines the needs analysis to build each functional module and build a model framework on this basis. In addition, in order to verify the performance of the model, this article conducts model analysis through practical teaching methods. The research results show that the model constructed in this paper has good performance.
Prediction of athlete movements using wearable sensors for sports person health monitoring application
Authors: Gao Tian , Lou Yantao , Sivaparthipan C.B. , Alazab Mamoun
Published: June 2021

Improvement in the data gathering to track the practise environments of the sports performance. Among these, the Internet of Things (IoT) technology with smartphones is increasingly evolving to help people with their health problems. In the world of athletics, wearable devices can provide real-time data to track athletes’ heart rhythms and help athletic activities. The players’ pulse rates change at various positions as they play sport and track their heartbeat, allowing them to understand their fitness and improve a person’s health. Therefore, the study proposes a wearable sensor-based athletic movement prediction (WS-AMP) model. The model uses the deep learning algorithm to effectively classify motions usually extracted from the interactive motion panels and determine how feasible it is to perform wearable sensor data classification. On 523 athletes with nine athletic motions, data on optical motion capture have been obtained. The research performs the deep neural network model’s training and validation, incorporating the convolutional neural network. The experimental study performs the prediction analysis and comparison with existing machine learning models. The experimental above analysis of wearable sensor-based IoT health monitoring of Sport person movements prediction are Abnormal Conditions ratio is 86.65%, Spectrum analysis of heart rate ratio is 87.12%, the Error rate of body maintenance ratio is 83.51%, Mental acuity ratio is 87.10% and finally overall accuracy, and F1 score ratio is 93.80%.
On practice and dilemma of artificial intelligence in collaborative teaching of the ideological and political theory course in colleges and universities
Authors: Yuanmeng
Published: June 2021

Computational ideological and political education is the product of the high degree of integration of ideological and political education with computers, big data, artificial intelligence and other information technologies, and is a new paradigm of ideological and political education in the information age. Through intelligent data collection, data model construction, algorithm analysis, simulation and other links, ideological and political education can not only scientifically explain the various complex ideological and political education phenomena that have already occurred, but also accurately calculate and predict the future state of the ideological and political education system, so that the discipline of ideological and political education can be like natural science, engineering technology through data, model, calculation, simulation and other scientific means. Realize from empirical research to empirical research in order to achieve the political goal of ideological and political education in a more scientific, accurate and efficient way. However, there are still a series of conceptual, technical, data, legal and ethical problems in the construction of computational ideological and political education. Through efforts from various aspects, design practical and guiding program strategies, so as to make full use of big data as a carrier to implement the innovation of college students’ ideological and political education into practice, and enhance the effectiveness of college students’ ideological and political education in the era of big data as the ultimate goal.
Inflammatory Myositis Secondary to Anti-Retroviral Therapy in a Child; Case Report and Review of the Literature
Authors: Monaghan Marie , Loh Charlotte , Jones Stephen , Oware Agyepong , Urankar Kathryn , Roderick Marion , Majumdar Anirban
Published: June 2021

Here, we describe a five year old girl with congenital HIV who had a six-week onset of rapidly deteriorating mobility and progressive proximal muscle weakness, associated with a raised Creatine Kinase (CK) level of 4330 U/L [25–200 U/L], subsequently diagnosed with an inflammatory myositis. Potential causes were investigated by paediatric neurology and immunology teams. Her viral load had been undetectable over the preceding two years, excluding a primary HIV myositis. While MRI scanning did not show evidence of definite myositis, a muscle biopsy showed evidence of an inflammatory process, comprising a moderate endomysial, perimysial and perivascular mononuclear (CD8 + T cell) infiltrate with increased MHC expression. No particular features of dermatomyositis or immune-mediated necrotising myopathy were identified and there were no features of an inclusion body myositis. Given the absence of active HIV infection, the role of anti-retroviral medications was considered. She had had a recent switch in medication, from twice daily Raltegravir (an Integrase Strand Transfer Inhibitor, INSTI) to once daily Dolutegravir (an INSTI) while continuing on an established daily protocol of Abacavir and Lamivudine (Nucleoside Reverse Transcriptase Inhibitors). Changing the Dolutegravir back to Raltegravir, in combination with continuing Lamivudine and Abacavir for two months made no difference to her weakness or CK levels. Moreover, this drug regimen had been well-tolerated over the preceding 19 month period. Changing the anti-retroviral regime completely to a single drug class (Protease Inhibitors) of Ritonavir and Darunavir, resulted in a dramatic improvement in her symptomatology. Within ten days she regained the ability to stand and walk, with a reduction in her CK from 1700 U/L at time of switch to 403 U/L [25–200]. This case highlights the potential risk of developing inflammatory myositis from anti-retrovirals even 19 months into treatment.
CLOVER-DBS: Algorithm-Guided Deep Brain Stimulation-Programming Based on External Sensor Feedback Evaluated in a Prospective, Randomized, Crossover, Double-Blind, Two-Center Study
Authors: Wenzel Gregor R. , Roediger Jan , Brücke Christof , Marcelino Ana Luísa de A. , Gülke Eileen , Pötter-Nerger Monika , Scholtes Heleen , Wynants Kenny , Juárez Paz León M. , Kühn Andrea A.
Published: June 2021

Background: Recent technological advances in deep brain stimulation (DBS) (e.g., directional leads, multiple independent current sources) lead to increasing DBS-optimization burden. Techniques to streamline and facilitate programming could leverage these innovations. Objective: We evaluated clinical effectiveness of algorithm-guided DBS-programming based on wearable-sensor-feedback compared to standard-of-care DBS-settings in a prospective, randomized, crossover, double-blind study in two German DBS centers. Methods: For 23 Parkinson’s disease patients with clinically effective DBS, new algorithm-guided DBS-settings were determined and compared to previously established standard-of-care DBS-settings using UPDRS-III and motion-sensor-assessment. Clinical and imaging data with lead-localizations were analyzed to evaluate characteristics of algorithm-derived programming compared to standard-of-care. Six different versions of the algorithm were evaluated during the study and 10 subjects programmed with uniform algorithm-version were analyzed as a subgroup. Results: Algorithm-guided and standard-of-care DBS-settings effectively reduced motor symptoms compared to off-stimulation-state. UPDRS-III scores were reduced significantly more with standard-of-care settings as compared to algorithm-guided programming with heterogenous algorithm versions in the entire cohort. A subgroup with the latest algorithm version showed no significant differences in UPDRS-III achieved by the two programming-methods. Comparing active contacts in standard-of-care and algorithm-guided DBS-settings, contacts in the latter had larger location variability and were farther away from a literature-based optimal stimulation target. Conclusion: Algorithm-guided programming may be a reasonable approach to replace monopolar review, enable less trained health-professionals to achieve satisfactory DBS-programming results, or potentially reduce time needed for programming. Larger studies and further improvements of algorithm-guided programming are needed to confirm these results.
α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum, and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease
Authors: Dos Santos Altair B. , Skaanning Line K. , Mikkelsen Eyd , Romero-Leguizamón Cesar R. , Kristensen Morten P. , Klein Anders B. , Thaneshwaran Siganya , Langkilde Annette E. , Kohlmeier Kristi A.
Published: June 2021

Background: Parkinson’s disease (PD) is a neurodegenerative disorder associated with insoluble pathological aggregates of the protein α-synuclein. While PD is diagnosed by motor symptoms putatively due to aggregated α-synuclein-mediated damage to substantia nigra (SN) neurons, up to a decade before motor symptom appearance, patients exhibit sleep disorders (SDs). Therefore, we hypothesized that α-synuclein, which can be present in monomeric, fibril, and other forms, has deleterious cellular actions on sleep-control nuclei. Objective: We investigated whether native monomer and fibril forms of α-synuclein have effects on neuronal function, calcium dynamics, and cell-death-induction in two sleep-controlling nuclei: the laterodorsal tegmentum (LDT), and the pedunculopontine tegmentum (PPT), as well as the motor-controlling SN. Methods: Size exclusion chromatography, Thioflavin T fluorescence assays, and circular dichroism spectroscopy were used to isolate structurally defined forms of recombinant, human α-synuclein. Neuronal and viability effects of characterized monomeric and fibril forms of α-synuclein were determined on LDT, PPT, and SN neurons using electrophysiology, calcium imaging, and neurotoxicity assays. Results: In LDT and PPT neurons, both forms of α-synuclein induced excitation and increased calcium, and the monomeric form heightened putatively excitotoxic neuronal death, whereas, in the SN, we saw inhibition, decreased intracellular calcium, and monomeric α-synuclein was not associated with heightened cell death. Conclusion: Nucleus-specific differential effects suggest mechanistic underpinnings of SDs’ prodromal appearance in PD. While speculative, we hypothesize that the monomeric form of α-synuclein compromises functionality of sleep-control neurons, leading to the presence of SDs decades prior to motor dysfunction.
An Emerging Role for Phosphoinositides in the Pathophysiology of Parkinson’s Disease
Authors: Schechter Meir , Sharon Ronit
Published: June 2021

Recent data support an involvement of defects in homeostasis of phosphoinositides (PIPs) in the pathophysiology of Parkinson’s disease (PD). Genetic mutations have been identified in genes encoding for PIP-regulating and PIP-interacting proteins, that are associated with familial and sporadic PD. Many of these proteins are implicated in vesicular membrane trafficking, mechanisms that were recently highlighted for their close associations with PD. PIPs are phosphorylated forms of the membrane phospholipid, phosphatidylinositol. Their composition in the vesicle’s membrane of origin, as well as membrane of destination, controls vesicular membrane trafficking. We review the converging evidence that points to the involvement of PIPs in PD. The review describes PD- and PIP-associated proteins implicated in clathrin-mediated endocytosis and autophagy, and highlights the involvement of α-synuclein in these mechanisms.
Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson’s Disease Patients
Authors: Youssef Priscilla , Kim Woojin S. , Halliday Glenda M. , Lewis Simon J.G. , Dzamko Nicolas
Published: June 2021

Background: The identification of reliable biomarkers in Parkinson’s disease (PD) would provide much needed diagnostic accuracy, a means of monitoring progression, objectively measuring treatment response, and potentially allowing patient stratification within clinical trials. Whilst the assessment of total alpha-synuclein in biofluids has been identified as a promising biomarker, conflicting trends in these levels across patient plasma samples relative to controls has limited its use. Different commercially available assay platforms that have been used to measure alpha-synuclein may contribute to different study outcomes. Objective: To compare different platform immunoassays for the measurement of total alpha-synuclein using the same plasma samples from 49 PD patients and 47 controls. Methods: Total plasma alpha-synuclein concentrations were assessed using the BioLegend, MesoScale Discovery, and Quanterix platform in plasma samples from PD patients and matched controls. Results: A significant increase in total plasma alpha-synuclein was observed in PD patients using the Biolegend (10%), Mesoscale Discovery (13%) and Quanterix (39%) assays. The Mesoscale Discovery and Quanterix assays showed the strongest correlations (r = 0.78, p < 0.0001) with each other, whilst the Quanterix platform demonstrated the lowest variation and highest effect size. Inclusion of age, sex and hemoglobin levels as covariates in the analysis of total alpha-synuclein improved the ability of all three immunoassays to detect a significant difference between patients and controls. Conclusion: All three immunoassays were sensitive enough to detect group level differences between PD patients and controls, with the largest effect size observed with the Quanterix assay. These results may help inform assay choices in ongoing clinical trials.
Gene Therapy for Parkinson’s Disease Associated with GBA1 Mutations
Authors: Abeliovich Asa , Hefti Franz , Sevigny Jeffrey
Published: June 2021

Human genetic studies as well as studies in animal models indicate that lysosomal dysfunction plays a key role in the pathogenesis of Parkinson’s disease. Among the lysosomal genes involved, GBA1 has the largest impact on Parkinson’s disease risk. Deficiency in the GBA1 encoded enzyme glucocerebrosidase (GCase) leads to the accumulation of the GCase glycolipid substrates glucosylceramide and glucosylsphingosine and ultimately results in toxicity and inflammation and negatively affect many clinical aspects of Parkinson’s disease, including disease risk, the severity of presentation, age of onset, and likelihood of progression to dementia. These findings support the view that re-establishing normal levels of GCase enzyme activity may reduce the progression of Parkinson’s disease in patients carrying GBA1 mutations. Studies in mouse models indicate that PR001, a AAV9 vector-based gene therapy designed to deliver a functional GBA1 gene to the brain, suggest that this therapeutic approach may slow or stop disease progression. PR001 is currently being evaluated in clinical trials with Parkinson’s disease patients carrying GBA1 mutations.
Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2021 Update
Authors: McFarthing Kevin , Rafaloff Gary , Baptista Marco A.S. , Wyse Richard K. , Stott Simon R. W.
Published: June 2021

Background: Despite the COVID-19 pandemic, there has been considerable activity in the clinical development of novel and improved drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD) during 2020. The agents that were investigated can be divided into “symptomatic” (alleviating the features of the condition) and “disease modifying” (attempting to address the underlying biology of PD) treatments, ST and DMT respectively, with further categorisation possible based on mechanism of action and class of therapy. Objective: Our goal in this report was to provide an overview of the pharmacological therapies –both ST and DMT - in clinical trials for PD during 2020–2021, with the aim of creating greater awareness and involvement in the clinical trial process. We also hope to stimulate collaboration amongst commercial and academic researchers as well as between the research and patient communities. Methods: We conducted a review of clinical trials of drug therapies for PD using trial data obtained from the ClinicalTrials.gov and World Health Organisation (WHO) registries, and performed a breakdown analysis of studies that were active as of February 18th 2021. We also assessed active drug development projects that had completed one clinical phase but were yet to start the next. Results: We identified 142 trials on ClinicalTrials.gov and 14 studies on the WHO registries that met our analysis criteria. Of these 156 trials, 91 were ST and 65 were DMT, Of the 145 trials registered on ClinicalTrials.gov in our 2020 analysis, 45 fell off the list and 42 were added. Despite this change, the balance of ST to DMT; the distribution across phases; the profile of therapeutic categories; and the proportion of repurposed therapies (33.5%); all remained very similar. There are only two DMTs in phase 3, and we identified 33 in-between-phase projects. Conclusions: Despite the effects of the coronavirus pandemic, investment and effort in clinical trials for PD appears to remain strong. There has been little change in the profile of the clinical trial landscape even though, over the past year, there has been considerable change to the content of the list.
The impact of new judging criteria on 10-8 scores in MMA
Authors: Gift Paul
Published: June 2021

This paper investigates the impact of changes in judging criteria on 10-8 scores in Zuffa-owned mixed martial arts (MMA) promotions. Utilizing a differences-in-differences framework, the 2017 liberalization of 10-8 scoring criteria in the Unified Rules of MMA is examined across various judge groups. Findings suggest that traveling judges and Nevada judges – those most likely to be at the forefront of the regulatory evolution of the sport – had already liberalized their 10-8 scoring one year prior to the effective date of the new criteria. Other judges appear to have effectively implemented the new criteria since January 2017 with 10-8 probabilities on par with traveling and Nevada judges. The effect of an earlier change in judging criteria is also examined in Nevada. Results suggest the numerous and distributed regulatory agencies involved in the sport of MMA were effective in the implementation of new policies for scoring rounds.
Evaluation of a rehabilitation program from the perspective of children with disabilities and their caregivers in Uruguay
Authors: Durán Cecilia , Abreu María del Carmen , Dapueto Juan J.
Published: June 2021

PURPOSE: The aim of the study was to evaluate the Assessment and Orientation Treatment Program for children and adolescents with disabilities treated at the Center Teletón Uruguay from the perspective of the patients and their parents based on several patient reported outcome measures: health related quality of life (HRQOL), treatment satisfaction, family impact, and emotional distress. METHODS: The sample consisted of all the 126 dyads of children/adolescents with ages ranging from 2 to 18 years and their primary caregivers who entered the program from April to October 2012. A set of instruments were filled out by children and parents before and six months after the program. T test for paired samples for continuous variables and McNemar’s test for categorical variables were used to assess changes pre and post intervention. RESULTS: There was a high prevalence of depression and anxiety in the caregivers. In the second evaluation, improvements that were statistically significant only for the caregivers were observed in the HRQOL of children, adolescents and caregivers. CONCLUSIONS: The patient reported outcome measures used were effective in detecting changes in several areas of the quality of life of children observed by their caregivers and in their own quality of life after the intervention.
Immersive virtual reality in children with upper limb injuries: Findings from a feasibility study
Authors: Phelan Ivan , Furness Penny J. , Dunn Heather D. , Carrion-Plaza Alicia , Matsangidou Maria , Dimitri Paul , Lindley Shirley
Published: June 2021

PURPOSE: Children who sustain Upper Limb Injuries (ULIs), including fractures and burns, may undergo intensive rehabilitation. The discomfort of therapy can reduce their compliance, limit their range of motion (ROM) and lead to chronic pain. Virtual Reality (VR) interventions have been found to reduce anticipated and procedural pain. This feasibility study aimed to explore perceptions and impacts of a custom-made, fully immersive Head-Mounted Display VR (HMD-VR) experience within a United Kingdom (UK) National Health Service (NHS) outpatient rehabilitation service for children with ULIs. METHODS: Ten children aged 9–16 in one UK Children’s hospital trialled HMD-VR during one rehabilitation session. They, their parents (n = 10), and hospital physiotherapy staff (n = 2) were interviewed about their perceptions of pain, difficulty, enjoyability, therapeutic impacts, benefits, and limitations. Children rated the sessions on enjoyability, difficulty, and pain compared to usual rehabilitation exercises. Physiotherapists were asked to provide range of motion readings. RESULTS: Inductive thematic analysis of interview data generated three themes, ‘Escape through Engagement’; ‘Enhanced Movement’; and ‘Adaptability and Practicality’. Children rated the session as more enjoyable, less difficult and painful than their usual rehabilitation exercises. Findings suggested that HMD-VR was an engaging, enjoyable experience that distracted children from the pain and boredom of therapy. Also, it seemed to enhance the movement they achieved. Participants perceived it was useful for rehabilitation and adaptable to individual needs and other patient groups. Suggestions were made to increase adaptability and build in practical safeguards. CONCLUSION: Findings from this small-scale feasibility study suggested HMD-VR was perceived as usable, acceptable, and effective with potential for further development. Future work could include larger scale trials.
An examination on ‘website accessibility’ for active engagement of visually impaired e-commerce customers
Authors: Santoki Smita , Patvardhan Neha
Published: June 2021

BACKGROUND:

The dominance of a digital wave is being felt in every sphere of the industry, and has been a big boon for online shoppers today. However, companies tend to ignore a section of their customer base, i.e. those who are visually impaired; although there are well-established standards set by WCAG 2.0 (Web Content Accessibility Guidelines). Although most e-commerce companies in India conform to these guidelines, as per the recommendations from the Indian government; however ironically; these are not accessible by the blind.

OBJECTIVE:

This paper specially focuses on the list of problems that the visually-impaired in India face while trying to access e-commerce sites, as most of the sites haven’t conformed to the WCAG 2.0 guidelines.

METHOD:

Qualitative analysis through the Repertory technique by Kelly in which, the grid developed for different constructs addressing various problems faced by such users in accessing e-commerce websites.

FINDINGS:

From the findings, it is evident that these visually impaired people are extremely open to gaining access towards the companies’ strategies, as they also want to be a part of the main segment of the society, and would in turn be a strong contributor to the profits of the companies, if they’re taken seriously. The findings also have a series of managerial as well as social implications.

CONCLUSION:

Further, the study also looks at lending some suggestions through which, marketing managers would be able to look into this prevailing problem, and thereby address the same, while enhancing their level of engagement with this specially-enabled client base. This would result not only in adding profits to the business at large, but also ensure customer satisfaction and delight, albeit the fact that they’re differently abled.
Characteristics of persistent postural perceptual dizziness patients in a multidisciplinary dizziness clinic
Authors: Azzi Jayson Lee , Khoury Michel , Séguin Jeanne , Rourke Ryan , Hogan Debora , Tse Darren , Lelli Daniel A.
Published: June 2021

BACKGROUND: Persistent Postural Perceptual Dizziness (PPPD) is a newly defined condition which was added to the International Classification of Vestibular Disorders in 2017. Little is known about its impact on patients. OBJECTIVE: The goal of this study was to analyze the symptomology, epidemiology and impact of PPPD on patients. METHODS: A retrospective chart review was done to identify patients who attended the Multidisciplinary Dizziness Clinic (MDC) and were diagnosed with PPPD. Responses to demographic questions, health-related quality of life surveys and several well-validated questionnaires commonly used to assess dizziness severity were analyzed. RESULTS: One hundred patients were diagnosed with PPPD between March 2017 and January 2019, of which 80%(80/100) were females. The average Dizziness Handicap Index score was 60.3±19.0. Responses to the Patient Health Questionnaire classified 53 patients (53/99;53.5%) as moderately to severely depressed. Sixty-four patients (64/100;64.0%) were minimally or mildly anxious according to the Generalized Anxiety Disorder scale. The average Vertigo Symptom Scale score was 24.1/60. The average Situational Vertigo Questionnaire score was 2.00. Forty-nine (49/100;49.0%) patients had migraine symptoms according to the Migraine Screen Questionnaire. CONCLUSIONS: In conclusion, patients with PPPD display important handicap and an elevated risk of depression, anxiety and migraines.
Vestibular semicircular canal function as detected by video Head Impulse Test (vHIT) is essentially unchanged in people with Parkinson’s disease compared to healthy controls
Authors: Hawkins Kim E. , Chiarovano Elodie , Paul Serene S. , Burgess Ann M , MacDougall Hamish G. , Curthoys Ian S.
Published: June 2021

BACKGROUND: Parkinson’s disease (PD) is a common multi-system neurodegenerative disorder with possible vestibular system dysfunction, but prior vestibular function test findings are equivocal. OBJECTIVE: To report and compare vestibulo-ocular reflex (VOR) gain as measured by the video head impulse test (vHIT) in participants with PD, including tremor dominant and postural instability/gait dysfunction phenotypes, with healthy controls (HC). METHODS: Forty participants with PD and 40 age- and gender-matched HC had their vestibular function assessed. Lateral and vertical semicircular canal VOR gains were measured with vHIT. VOR canal gains between PD participants and HC were compared with independent samples t-tests. Two distinct PD phenotypes were compared to HC using Tukey’s ANOVA. The relationship of VOR gain with PD duration, phenotype, severity and age were investigated using logistic regression. RESULTS: There were no significant differences between groups in vHIT VOR gain for lateral or vertical canals. There was no evidence of an effect of PD severity, phenotype or age on VOR gains in the PD group. CONCLUSION: The impulsive angular VOR pathways are not significantly affected by the pathophysiological changes associated with mild to moderate PD.
Subjective versus objective tests of dizziness and vestibular function in epidemiologic screening research
Authors: Cohen Helen S. , Sangi-Haghpeykar Haleh , Plankey Michael W.
Published: June 2021

BACKGROUND: Many epidemiologic studies of vestibular disorders are based on responses to questionnaires which have not been tested against objective tests of the vestibular system. OBJECTIVE: The goal was to determine if the dizziness and balance questions used in the National Health Interview Survey (NHIS) are valid and predict performance on objective tests of the vestibular system (VNG). METHODS: Data from 367 participants recruited from the community, aged 21.4 to 87.6 years, were collected in the Otolaryngology department at a tertiary care center. They were asked the eight NHIS questions twice, at least 30 minutes apart and were tested on VNG. RESULTS: Question responses changed from Test 1 to Test 2 and differed between males and females. “Yes” responses did not predict abnormal VNG responses, for the total group and when the group was categorized into younger (<60 years) and older (>60 years) subjects. The sensitivity and specificity of all questions was low. CONCLUSION: The NHIS questions provide some information about what people recall of their experiences, but they may not provide insight into the diagnostic prevalence of vestibular and balance disorders because the sensitivity and specificity are too low. Questionnaire-based epidemiologic studies should be interpreted with caution.
Application of 70 kVp in abdominal CT angiography to reduce both radiation and contrast dosage and improve patient comfort for children
Authors: Sun Jihang , Li Haoyan , Yang Lixin , Zhou Zuofu , Li Michelle , Peng Yun
Published: June 2021

BACKGROUND: Low-tube voltage scanning improves CT attenuation value of contrast medium (CM). Thus, we hypothesized that 70 kVp in pediatric abdominal CT angiography (CTA) could be used to reduce both radiation and CM dose and improve patient comfort at the same time. OBJECTIVE: To evaluate the feasibility of using 70 kVp in pediatric abdominal CTA to reduce radiation dose and CM dose and improve patient care for children. MATERIALS AND METHODS: Forty-six children needing abdominal CTA were enrolled in the study group using low-dose scanning protocol with 70 kVp and 0.7–1.1 ml/kg contrast dose, and reconstructed with 50%ASIR-V. They were compared with other 46 children in control group with matching body weight and underwent conventional CT scans with 100 kVp, 1.2–1.8 ml/kg contrast dose and reconstructed using 50%ASIR. Image quality of large vessels was evaluated using a 5-point scale. CT value and standard deviation of descending aorta (Ao) was measured, and signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Radiation dose, contrast dose, the maximum injection pressure between the two groups were also compared. RESULTS: Score for displaying large vessels by 70 kVp images was 3.91±0.28, lower than that (4.17±0.38) of the control group (p < 0.05), but fully met the diagnostic requirements. CT value of Ao was 390.87±86.79HU in study group, which is higher than 343.93±49.94HU in control group, while there was no difference in SNR and CNR between two groups; the radiation dose, contrast dosage and injection pressure of the study group were 1.23±0.39mGy, 12.67±7.27 ml and 43.83±17.16psi, respectively, which are significantly lower than the 1.95±0.37mGy, 22.67±7.39 ml, and 77.59±19.68psi of control group. CONCLUSION: Use of 70 kVp in pediatric abdominal CTA provides diagnostic quality images while significantly reduce radiation and contrast dose, as well as injection pressure to improve patient comfort for children.
STRUCTURE OF INFORMATIONAL AND ANALYTICAL SUPPORT OF URBAN ENGINEERING ACTIVITIES IN THE SPHERE OF LAND USE PLANNING AND MANAGEMENT
Authors: Synhayivska Oleksandra , Cherednichenko Oleksandra
Published: June 2021

Research paper "The structure of informational-analytical support of urban engineering activities in the field of land use planning and management" consists of - introduction, 6 sections, 5 infological models, conclusions, and a list of 35 sources. The object of the study are methods and models of the discipline of land use planning and management.

The subject of the research is the structure of informational support of urban planning activity, cadastral survey and expert systems.

The purpose of the paper: to develop the structure of informational and analytical support of urban planning models, and also structural and logical models of natural conditions and processes, activities and structures in the field of land use planning and management.

Area of application: information support of all types of urban planning activities. It is advisable to use the results of the work for Improvement of informational support of legislative bodies, municipal administrations and other institution responsible for urban development.
DETERMINATION OF TRANSPORT ACCESSIBILITY IN THE FORMATION OF TOURIST ROUTES USING QGIS AND GRASS GIS
Authors: Tretiak Vladyslav , Lepetiuk Viktoriia
Published: June 2021

The creation of modern tourist products contributes to the attractiveness of our country in the market of tourist services. Transport accessibility is an important aspect for creating tourism products. This study considers the algorithm for determining transport accessibility for the projection of tourist travel routes, based on the use of geographic information technologies. Transport accessibility is determined by collecting and filtering data and subsequent creation of isochron maps, which show the time distance when moving a particular mode of transport along the lines of the road network from points of interest. Attractions of Ternopil region were chosen as such points of interest for tourists. The paper uses open OSM data on tourist facilities and the road network. Data preparation was performed using PostgreSQL software. When performing the study, the QGIS program was used, in which data processing was performed. Spatial analysis is performed in the spatial information processing environment GRASS GIS; data processing modules or GRASS GIS plug-ins are used. The proposed algorithm allows forming a database of tourist facilities, transport routes, to define more accurately existing tourist routes, to create new ones. As a test in the course of the study, the route of the tour of Ternopil was designed, in the construction of which an isochron map was used. Spatial analysis helps to better determine the path of the tourist tour and its duration.
OVERVIEW OF INFORMATION TECHNOLOGIES OF BUSINESS PROCESS MANAGEMENT IN ORGANIZATIONS
Authors: Danchenko Olena , Bedrii Dmytro , Semko Alexander
Published: June 2021

The basic business management is the management of the structure of business processes. The success and efficiency of management is a complex and quite capacious activity, which depends on the chosen tools, in particular, the use of information technology. The IT market demonstrates a wide variety of software products for business process development and management. The article is devoted to the study of modern IT products and determine its specifics. The management methodology has a wide range of business process management tools. The authors consider the main business process management systems: BPMS, which provides opportunities to implement business processes in accordance with their formal model; IDEF standard methodology of the ICAM family whose purpose is to model complex systems, display and analyze the model; ARIS, which allows you to create systems of balanced scores and optimize business processes in accordance with these indicators; BPMN, the feature of which is the ability to describe and model business processes; BPEL standard created for the design and execution of business processes. Considered languages: YAWL, which is used to formally describe business processes; UML is a unified modeling language used in the object-oriented programming system, it contains object-oriented notations. The article discusses only some of the methods used by company managers to effectively manage business processes. Studies of even a small proportion of these methods provide a number of benefits, but it is important to remember that simply mastering these tools in business process management does not guarantee success, but its absence can lead to loss of competitiveness, reduced market share and low efficiency.
Fresh bread to the last piece
Authors:   Moscow State University of Food Production, Novozymes, Matveeva I.V. , Bobyshev K.A. ,   Moscow State University of Food Production, Novozymes
Published: June 2021

The use of technological solutions based on enzyme preparations of maltogenic amylase of the Novamyl® Boost series and Novamyl® 3D BG by Novozymes company allows to prolong the freshness and softness of high-prescription products.
Rational modes of drying a thick starter culture from bioactivated wheat grain with a hop composition
Authors:   Voronezh state University of engineering technologies, Alyokhina N.N. , Ponomareva E.I. ,   Voronezh state University of engineering technologies, Gar`kina P.K. ,   Penza State Technological University, Fomenko A.Yu. ,   Voronezh state University of engineering technologies
Published: June 2021

This article presents the results of research on the choice of rational modes of drying thick sourdough. To obtain the best properties of the dough and the quality of grain bread, it is recommended to dry a thick starter culture of bioactivated wheat with a hop composition at a layer thickness of 1cm and a temperature of no more than 50°C
Enrichment of bakery products using non-traditional vegetable raw
Authors:   Moscow State University of Food Production, Bogatyreva T.G. , Belyavskaya I.G. ,   Moscow State University of Food Production, Muratova A.A. ,   Moscow State University of Food Production
Published: June 2021

The purpose of the research is to substantiate the rational bread technology and a way to increase its nutritional value of bread by using spelled flour. The article discusses the advantages of using spelt flour in the baking industry. The determination of the rational parameters of the technological process was carried out on the basis of studying the dynamics of the gas-forming ability of the dough in conjunction with the change in acidity at the stage of fermentation of semi-finished products
An Efficient ROI Image Watermarking on Geometric Attacks
Authors: Degadwala Dr. Sheshang D. , Chaudhary Sanjay , Gaur Sanjay , Vyas Dhairya
Published: June 2021

Watermarking is raised to apparatus for the Privacy of Intellectual Property Rights (IPR) of combination dates. In this paper, in the starting we have to fill the user name field and password field which will be secure afterwards that it will be make QR-code using zxing library and it is transformed into binary patterns for share-1 that is called Visual cryptography algorithm. Now share-2 is store into server database and it will be furthered use in future situation at receiver way. Now share-1 is hiding into the LL-Band with the help of DWT-SVD into block manner with Pseudo Zernike moment. Then it is sent to the network or internet. As in network there are many unlike attackers whose apply any Rotation, Scaling or Translation attacks on the hiding image. Attack image is expected at the end side or receiver side. To get prevent against attacks here at the starting stage use Pseudo Zernike moment then after Surf based feature extraction and it will recover the attacks pixel and scaling parameters value and using affine transformation recover the rotational parameters value. So then scale value and angle value is apply on attack image recovered watermark image. Now using DWT+SVD block method extract the water mark share-1. So on system with share-1 and another share-2 will be in server side so now by using EX-OR process for getting QR-Code. At the last stage QR-code is translated and fill field user name and password vale to login the system successfully.
Linear Gantry Robot Control System
Authors: Date Siddhi , Makwana Shreya , Mewada Divya , Degadwala Dr. Sheshang D.
Published: June 2021

A Linear Robot comprises of a controller mounted onto an overhead framework that permits development over a flat plane. Gantry are likewise called Cartesian or straight robots. Direct Gantry Robot will be made which will pick and place the things in ideal spot. Initially, a robot with two hub primarily x-hub and y-hub will be made utilizing different electronic instruments after that one programming will be made will provide guidance to the robot to move according to the necessity. The product will be configuration utilizing python programming and will be constrained by Linux working framework and furthermore by Raspberry pi’s GPIO header. By making this framework the effectiveness will expand, takes less floor space, will be lower in expense and it can accomplish substantial payloads.
Considerações sobre a prevenção do câncer de mama feminino
Authors: Thuler Luiz Claudio
Published: June 2021

O controle de câncer de mama deve priorizar a prevenção e a detecção precoce. A prevenção não deve focalizar apenas os fatores de risco associados ao câncer de mama mas também os fatores de proteção. Alguns fatores que aumentam o risco de desenvolver câncer de mama, como obesidade na pós-menopausa, exposição à radiação ionizante em altas doses, exposição a pesticidas/organoclorados e tabagismo são passíveis de intervenção; outros fatores como sexo feminino, avanço da idade, menarca precoce, menopausa tardia, primeira gestação tardia, história de câncer de ovário ou de mama ou história de doença mamária benigna, alta densidade mamária, mutações genéticas (BRCA1 e BRCA2) e história familiar de câncer de mama não podem ser modificados. A maioria destes fatores encontra-se associada com um moderado aumento no risco (cerca de 2 ou 3 vezes), o que sugere que múltiplos fatores contribuem para a gênese da doença e que podem existir fatores ainda desconhecidos. Por outro lado, há duas estratégias principais para a detecção precoce do câncer de mama: a educação para promover o diagnóstico precoce e o rastreamento. As evidências obtidas de ensaios clínicos sugerem uma diminuição de 25% da mortalidade por câncer de mama com o rastreamento mamográfico de rotina. Além disso, há evidências indiretas de que o rastreamento por exame clínico das mamas reduza o número de mortes por este câncer.
Controle do Câncer de Mama - Documento de Consenso
Authors: Instituto Nacional de Câncer José Alencar Gomes da Silva
Published: June 2021

Este documento de consenso apresenta as recomendações emanadas dessa oficina para a prevenção, detecção precoce, diagnóstico, tratamento e cuidados paliativos no câncer de mama e aponta possíveis estratégias que devem ser utilizadas para a sua implementação no Sistema Único de Saúde.