bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelaksanaan Pendekatan Bermain dalam Pengajaran dan Pembelajaran Matematik Awal
Authors: Osman Farah Najwa , Mohamed Suziyani
Published: March 2023

Pendekatan bermain dilihat sebagai satu teknik pengajaran dan pembelajaran (PdP) yang mampu mengembangkan potensi kanak-kanak secara holistik. Kajian ini dilaksanakan bagi mengenal pasti pelaksanaan pendekatan bermain dalam PdP Matematik Awal. Pendekatan kuantitatif berbentuk tinjauan digunakan dalam kajian ini. Borang soal selidik sebagai instrumen kajian digunakan dalam pengumpulan data. Sampel terdiri daripada 49 orang guru prasekolah sekitar daerah Tangkak, Johor dengan menggunakan kaedah pensampelan mudah. Perisian Statistical Package for Social Science (SPSS) versi 26.0 digunakan dalam penganalisisan data. Dapatan kajian menunjukkan pelaksanaan pendekatan bermain dalam pengajaran dan pembelajaran Matematik Awal adalah tinggi. Hal ini menerangkan bahawa guru menggunakan pendekatan bermain dalam PdP Matematik Awal. Kajian ini membantu guru dalam merancang pelaksanaan pendekatan bermain dalam PdP Matematik Awal.
Hubungan antara Motivasi dengan Pencapaian Matematik Murid Tahun Lima
Authors: Meng Li Chew , Mydin Kutty Faridah
Published: March 2023

Motivasi adalah antara elemen penting yang memberi kesan ke atas pencapaian Matematik murid. Justeru, pencapaian Matematik murid di Malaysia masih kurang bersaing di persada antarabangsa. Satu kajian kuantitatif dijalankan untuk mengenal pasti tahap pencapaian murid dan tahap motivasi murid. Hubungan antara kedua-dua pemboleh ubah ini turut dilihat. Teknik pensampelan rawak digunakan untuk penentuan bilangan responden dalam kajian. Borang soal selidik diagihkan kepada 250 murid sekolah rendah dari sebuah daerah di Negeri Sembilan. Hasil kajian ini menunjukkan tahap pencapaian matematik responden masih perlu dipertingkatkan, manakala tahap motivasi responden berada pada tahap yang sederhana tinggi (min = 3.14; s.p = 0.745). Didapati hubungan antara motivasi murid dan tahap pencapaian dalam mata pelajaran Matematik adalah lemah tetapi signifikan, r(250) = 0.299, p = .000 (p < 0.01). Kajian ini memberikan implikasi kepada pihak sekolah dan para pendidik untuk meningkatkan motivasi murid dalam menguasai mata pelajaran Matematik. Hal ini penting supaya memastikan langkah intervensi dapat diambil oleh pihak berkenaan dari peringkat yang lebih awal untuk meningkatkan tahap motivasi murid dimana motivasi Matematik perlu dibina dari peringkat kanak-kanak.
Symmetrical Cryptosystems based on Cellular Automata
Authors: Ostapov Serhii , Diakonenko Bohdan , Fylypiuk Maksym , Hazdiuk Kateryna , Shumyliak Liliia , Tarnovetska Olha
Published: March 2023

This paper deals with the development of two symmetric encryption algorithms on the basis of cellular automata: a block cipher, that is based on AES and uses three-dimensional cellular automata; a stream cipher, that exploits a hardware-software entropy generation (tracking of keystrokes and mouse pointer movement), as well as the developed hash function, based on “cryptographic sponge” architecture of SHA-3, modified by cellular automata transformations. The block cipher is designed in architecture of SP-network and uses the AES substitution block. Permutation layer and key generation is designed on the basis of cellular automata rules (rules “22”, “105” and “150”). The optimal number of rounds to achieve maximum crypto resistance is determined. The stream cipher is designed on the basis of hardware-software entropy generation and uses the cryptographic hash-function in the SHA-3 architecture. Permutation function is developed on the basis of cellular automata rules (rules “30” and “146”). The procedures of shift and permutation of rows and columns is used for better permutation. A final permutation of state elements is used to improve the avalanche effect. The received results are analyzed and summarized; the conclusions and justifications about cipher parameters (like number of rounds, where needed) are made.
Algorithm for Calculation the Carry and Borrow Signs in Multi-digit Operations in the Parallel Computational Model
Authors: Tereshchenko Andrii , Zadiraka Valeriy
Published: March 2023

The fast algorithm to calculate carry signs and borrow signs for implementation of fast multi-digit operations in the parallel computational model is proposed. The proposed algorithm also makes it possible to predict carry signs in the case of an addition operation and predict borrow signs for a subtraction operation. It is shown how the sign prediction algorithm is implemented in operations in which each parallel processor proceeds the separate group of words into which multi-digit numbers are divided. The iterative calculations of carry signs of grouped words are described. The sign calculation algorithm as component of new modifications of multi-digit addition, subtraction, comparison, the sum of three or more numbers in the parallel computational model is presented. The sign calculation algorithm provides general approach to the implementation of multiplication, division, multiplication by modulo, exponentiation by modulo in the parallel computational model. In the form of a table, a general analysis of the complexity of algorithms and an analysis of the complexity by the number of single-word operations per processor are given.
Study on the determination of some diamine in urine by LC-MS/MS
Authors: Tong Thi Ngan , Mai Ngọc Thanh , Nguyen Thi Hien , Pham Thi Quyen , Nguyen Phuc Dan , Nguyen Thi Huyen , Nguyen Thi Minh Hoa , Vu Tung Lam , Chu Thi Thu Hien , Hoang Thi Lan Anh , Nguyen Thi Anh Huong ,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Vietnam,   Vietnam National Institute of Occupational Safety and Health, Hanoi, Vietnam,   Vietnam National Institute of Occupational Safety and Health, Hanoi, Vietnam,   Vietnam National Institute of Occupational Safety and Health, Hanoi, Vietnam,   Vietnam National Institute of Occupational Safety and Health, Hanoi, Vietnam,   Vietnam National Institute of Occupational Safety and Health, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Vietnam,   Department of Chemistry, Faculty of Building Materials, Hanoi University of Civil,   Military Institute of Preventive Medicine, Hanoi, Vietnam,   Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Vietnam
Published: March 2023

Isocyanate is a common name for chemical compounds containing one or more - NCO groups. There have been many studies showing that isocyanates pose a risk to human health when exposed and can cause occupational poisoning. When absorbed into the body, the isocyanates will be converted into the corresponding amines. Therefore, the determination of these diamines in urine will contribute to the assessment of exposure to isocyanates. This article presents a study on simultaneous determination of 4,4′-methylenedianiline (MDA), hexamethylene diamine (HDA), isophoron diamine (IPDA) in urine by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method detection limit (MDL) were 0.074, 0.059, and 0.053 ng/mL for HDA, MDA, IPDA, respectively. The method quantitation limit (MQL) were 0.243, 0.194 and 0.177 ng/mL for HDA, MDA, IPDA, respectively. The method's recovery ranged from 86.38 to 105.3% with the repeatability RSDr < 6%. The method was successfully applied to simultaneously determine the content of HDA, MDA and IPDA in 30 urine samples of workers at auto repair garages in Bac Ninh province. The results showed that HDA, MDA and IPDA were detected in these samples with different concentrations.
Vali’nin Portresi: Kavalalı Mehmet Ali Paşa’nın Görsel Temsilleri
Authors: Uzun Tolga
Published: March 2023

Kavalalı Mehmet Ali Paşa, Fransa’nın Mısır’ı işgali sırasında gösterdiği başarılar neticesinde Osmanlı hükümeti tarafından Mısır valisi olarak atanmıştır. Valiliği sırasında başlattığı isyan bastırılamamış ve özerk bir statüde Mısır’da hükümdar gibi davranmıştır. Mısır için bir modernite çağı olarak kabul edilen döneminde Avrupa’ya öğrenci göndermek, modern sulama sistemleri ile bölgenin tarımını geliştirmek, silah fabrikaları kurarak modern teçhizatlı bir modern ordu kurmak gibi birçok konuda yeni bir çağın habercisi olmuştur. Yaptırdığı dini ve sivil mimari eserlerde Avrupa ve Osmanlı üsluplarını yerel değerler ile birleştirmesini bilmiş özellikle saraylarında Osmanlı barok yorumlu bezemelere yer vermiştir. Çok sayıdaki portrelerinde geleneksel Osmanlı-Rumeli kıyafetleri ile betimlenen paşanın bir kıyafet reformuna gitmediği, çağdaşı Osmanlı ve İran’daki Müslüman hükümdarların izlediği 19. yüzyılın yeni portrecilik anlayışını benimsemediği anlaşılır. Bu anlamda bir Osmanlı ayanı gibi davranan paşanın portreleri genellikle yabancı ressamlar tarafından yapılarak 19.yüzyılın ilk yarısında Mısır’ı anlatan kitapların içinde yer almıştır. Az sayıdaki davetli Avrupalı ressam tarafından tuval üzerine yağlı boya tekniğindeki portreleri Mısır ve Avrupa müzelerine dağılmıştır.
Implementation of Agent Based Smart Parking System using IoT
Authors: Prof. Kavita Patil  , Akshay Deepak More  , Atharv Rahul Taware  , Mayur Ganesh Todkar  , Swaraj Praful Deshmukh
Published: March 2023

Due to the increasing number of automobiles on the roads worldwide, parking space problems have arisen in many areas, causing people to spend a considerable amount of time searching for a place to park. This study proposes a smart mobile parking booking system utilizing an agent-based model. The algorithm considers the driver's location, speed, desired destination, preferred parking charge, and arrival time, to determine the most suitable and available parking spot for them. The agent-oriented approach is utilized to represent the system, with each agent responsible for addressing a particular issue
Routerich
Authors: Tarannum Shaikh  , Pranav Rajshekar Karlekar  , Prathmesh Vijay Kokare  , Shravani Mohan Mohite  , Maryam Javed Shaikh  , Shrutika Pravin Shinde
Published: March 2023

GPS-based navigation systems have become an integral part of our day-to-day lives. People frequently use these systems to find their way around due to their usability and ease of use. Google Maps is currently the most widely used navigation system in the world. Alongside providing routes and navigation, it also provides information about traffic, weather conditions, and even feedback and reviews of the places you are visiting. But none of the existing navigation systems advises you about the underlying road conditions. Although they suggest the shortest route, it may not be the best route. Many times, you even end up reaching a dead end as a result of relying on these systems. In the midst of all this, a navigation system that can suggest routes not only based on the shortest distance but also based on underlying road conditions with real-time feedback has become a necessity. The goal of this paper is to efficiently search for the most accessible alternative paths in a multi-route navigation system
A Literature Review on Developing A Project Performance Measurement Strategy for Construction Project
Authors: Srinivasan A  , Aswin Bharath A
Published: March 2023

This project aims to develop a project performance measurement strategy for construction projects using Objectives and Key Results (OKRs) methods. Construction projects are complex and involve multiple stakeholders, tasks, and objectives. Therefore, it is crucial to have a robust performance measurement strategy in place to ensure that the project is completed on time, within budget, and with the desired quality. This literature review aims to analyses the existing research on developing a project performance measurement strategy for construction projects. The review will cover topics such as the objectives of project performance measurement, the challenges in measuring project performance, the methods for developing a performance measurement strategy, and the key performance indicators (KPIs) used in the construction industry. Additionally, the review will examine the application of the Objectives and Key Results (OKR) method for project performance measurement and its effectiveness in the construction industry. The literature review will provide valuable insights into the best practices for developing a project performance measurement strategy for construction projects, and will be useful for project managers, researchers, and practitioners in the construction industry.
Un laboratorio remoto de código abierto y bajo coste para el brazo robótico educativo Dobot Magician
Authors: Chacon Jesús , Goncalves Daniela , Besada Eva , López-Orozco Jose Antonio
Published: March 2023

Este artículo presenta el laboratorio remoto diseñado en la Universidad Complutense de Madrid (UCM) para dar acceso remoto, a través de Internet, al robot educativo Dobot Magician. El software del laboratorio remoto está formado por el servidor web ReNoLabs (programado en Node.js) que gestiona el acceso al laboratorio, despliega sus páginas web, y sirve como pasarela de comunicación entre el software de control (programado en Python) que interactúa directamente con el robot) y la interfaz gráfica web de la experiencia (diseñada en EJsS). EJsS también se utiliza para gestionar de forma centralizada el laboratorio, al haber ampliado su funcionalidad mediante un Plugin. Además, el software anterior, creado con herramientas software gratuitas, se ejecuta sobre una Raspberry Pi y el interfaz web de la experiencia puede integrarse, si así se desea, en un sistema de gestión de aprendizaje general como Moodle. Finalmente, el artículo también presenta un par de ejemplos de uso del laboratorio remoto.
Aplicación de estrategias psicológicas y sociales para incrementar el vínculo en interacción humano-robot
Authors: Carrasco Martínez Sara , Gamboa Montero Juan José , Maroto Gómez Marcos , Alonso Martín Fernando , Salichs Miguel Ángel
Published: March 2023

La robótica social se encuentra ante el reto de diseñar robots que sean útiles para la sociedad, se puedan utilizar con frecuencia, y en los que la gente confie. Este problema se puede abordar desarrollando robots con alto grado de vinculación y compromiso con sus usuarios. Proponemos aplicar diversas estrategias relacionadas con la psicología social y la teoría de juegos en el campo de la robótica social. El objetivo es conseguir una vinculación entre el robot y sus usuarios, produciendo tiempos de interacción más largos para aumentar el uso del robot de manera diaria. La combinación de las diferentes estrategias se centra en desarrollar robots sociales que faciliten y promuevan la interacción con sus usuarios. Como novedad en este trabajo se incorporan estrategias de alto grado de vinculación en el campo de la robótica social. En concreto, para mejorar la utilización y el enganche en nuestro robot social Mini. Además, se muestran los resultados obtenidos en la validación de las estrategias propuestas en experimentos realizados por 21 participantes de avanzada edad. Estos resultados demuestran la utilidad de nuestro sistema para aumentar el tiempo de interacción con el robot durante ejercicios de entretenimiento.
Exploración dinámica de fronteras en entornos desconocidos basada en la entropía
Authors: Godoy-Calvo Jaime , Lin-Yang Dahui , Vázquez-Martín Ricardo , García-Cerezo Alfonso
Published: March 2023

La exploración en entornos de catástrofes proporciona información valiosa de alta fidelidad al personal de los dispositivos de rescate ante situaciones de desastre, ofreciendo la posibilidad de reducir el tiempo de búsqueda y recuperación de víctimas. Este trabajo presenta un método de exploración que evalúa las fronteras del entorno conocido basado en la entropía mediante una función de expectativa, con el objetivo de maximizar la ganancia de información. De esta forma el método propuesto emplea esta métrica para planificar la exploración en base a la expectativa de ganancia de información futura, asegurando una estrategia que minimiza el tiempo de exploración al mismo tiempo que maximiza la incorporación de nueva información al mapa. Debido al enfoque empleado para resolver el problema se consigue evitar la dependencia del método de ganancia de información con los mapas de tamaño fijo, y se propone un modelo independiente del sensor utilizado en la exploración donde se considera la distribución de obstáculos en la cercanía de las fronteras. Para su evaluación, se presentan resultados en diferentes entornos con simulaciones que demuestran la mayor eficiencia en la planificación de la exploración de las zonas desconocidas hasta completar el conocimiento completo del entorno a explorar. El método propuesto está públicamente disponible en Godoy-Calvo et al. (2022).
Teoria e conceitos de sustentabilidade, conforto ambiental e questões bioclimáticas: reflexão contemporânea
Authors: Araújo Eliete
Published: March 2023

O livro apresenta uma coletânea de resumos produzidos pelos alunos da turma de Mestrado em Arquitetura e Urbanismo do CEUB, do segundo semestre de 2022. Uma turma diversificada formada por profissionais jovens e experientes, servidores públicos e da iniciativa privada, representantes da área de arquitetura, engenharia e psicologia. Os resumos foram produzidos a partir da leitura de títulos que fizeram parte da disciplina de Sustentabilidade, Conforto Ambiental e Questões Bioclimáticas, ministrado pela professora pós-doutora, Eliete de Pinho Araujo. A disciplina teve a proposta de expor temas e conceitos de sustentabilidade; discutir acerca das soluções de conforto ambiental adotadas na arquitetura e promover debates sobre aspectos bioclimáticos. O objetivo geral foi ampliar os conceitos referentes à qualidade do ar, ao meio ambiente e à saúde da população. Especificamente, foi a oportunidade de desenvolver a explanação, o debate e a elaboração das sínteses que se apresentam a seguir, relacionando os temas lidos com sustentabilidade, conforto ambiental e questões bioclimáticas. A metodologia utilizada foi a distribuição dos títulos entre os alunos. Cada um escolheu considerando a afinidade promovida pela vivência profissional ou aquele tema que tivesse relação com a dissertação a ser desenvolvida ao longo do curso. A partir de cada leitura foram realizadas exposições do tema abordado pelo autor que desencadearam as discussões na sala de aula. Exercendo o papel de mediadora, a professora instigou a classe a promover a correlação entre os livros estudados e os temas da disciplina. O resultado foi a produção de 23 textos que abordam assuntos bem diversos, mas capazes de se relacionarem facilmente com o tema sustentabilidade, conforto ambiental e questões climáticas. Em decorrência do desenvolvimento deste trabalho, que promoveu a condução de debates em sala, a produção de texto a partir de conhecimentos extraídos de publicações de grande relevância pedagógica, a turma pode compreender o significado e o sentido da docência na educação superior para a formação de professores no contexto da sociedade atual.
Diagnosis and treatment of congenital hypothyroidism
Authors: Lee Hye Jin
Published: March 2023

Background: Congenital hypothyroidism is the most common neonatal endocrine disorder, and prompt screening and treatment initiation can prevent developmental delay and growth failure.Current Concepts: The thyroid is the first endocrine gland to develop during embryogenesis. Regulation of thyroid function requires normal development of the hypothalamic-pituitary-thyroid axis, which occurs during the embryonal and neonatal periods. Defects in any of the steps involved in development and differentiation of the gland and regulation of thyroid function lead to permanent congenital hypothyroidism. Neonatal screening test programs to detect congenital hypothyroidism, which are established in 1/3 of the countries worldwide, are cost-effective with high sensitivity and specificity. Advances in molecular testing have expanded knowledge and understanding of thyroid development and function. Prompt initiation of an accurate dose of sodium levothyroxine is recommended. Frequent follow-up, including laboratory test evaluation and dose adjustments are important to maintain thyroid hormone levels within their target ranges.Discussion and Conclusion: A well-established system of newborn screening and treatment of congenital hypothyroidism is useful for management of term infants without other risk factors for this disorder. However, increasing knowledge regarding the role of genetic causes and new criteria for screening and treatment of neonates in special conditions is emerging in clinical practice.
Gestión del proceso y abordaje de la lista de espera quirúrgica en el hospital Essalud Almanzor Aguinaga asenjo – Chiclayo
Authors: Calderón-Vílchez Claudia
Published: March 2023

El objetivo fue determinar la relación existente entre la gestión del proceso y el abordaje de la lista de espera quirúrgica en un hospital EsSalud de Chiclayo. Para ello, se desarrolló un estudio cuantitativo, de alcance correlación transversal, con la técnica de encuesta y con dos instrumentos, uno de 12 preguntas y el segundo de 10 preguntas dirigido a los profesionales y administrativos que ascendió a un total de 30. Se utilizó la prueba de correlación de Pearson. Los resultados mostraron niveles inadecuados de la gestión por procesos (66,7%) y para el abordaje de la lista de espera quirúrgica (56,7%). Concluyendo que existe una alta relación entre la gestión del proceso de programación quirúrgica y el abordaje de la lista de espera en el hospital EsSalud- Chiclayo (r2=,797; p=,000), además el coeficiente de determinación establece que la gestión de dicho proceso explica la lista de espera quirúrgica en un 63,5% y el 26,5% se debe a otros factores.
Estudio serotípico del virus del dengue y características clínicas en pacientes con enfermedad febril aguda
Authors: Rafael-Heredia Arturo , Iglesias-Osores Sebastian , Zuñiga-Valdera Gabriel , Acosta-Quiroz Johana
Published: March 2023

El objetivo del presente estudio fue determinar la frecuencia de los serotipos del virus Dengue (DENV) y describir su presentación clínica en pacientes con enfermedad febril aguda, enero-junio del 2020, Perú. De un total de    muestras de suero de los centros de salud se estudió la presencia de DENV mediante RT-PCR, antígeno NS1 y anticuerpos IgM. Se usó un cuestionario estandarizado para recolectar la información de síntomas clínicos. Dentro de la evaluación de 496 pacientes con enfermedad febril aguda (AFI) y con dengue sospechosos se estudiaron, consecutivamente entre los meses de enero a junio. Dentro de los síntomas evaluados, 495 (99 %) pacientes entre mujeres y hombre presentaron fiebre y solo 1 persona lo contrario. Los siguientes síntomas fueron evaluados según la incidencia de casos: artralgias presentes en 372 (75 %) personas; mialgias en 340 (68,5 %), cefaleas en 341 (68,8 %), dolor ocular en 321 (64,7 %), dolor lumbar en 303 (61,1 %), rash extrema en 189 (38,1 %) presentando incidencia en adolescentes, cuadro de conjuntivitis en 92 (18,5 %) y náuseas en 185 (37,3 %). El diagnóstico de Dengue demostró que el NS1 y la IgM anti DENV tiene su sensibilidad y especifica válida.
Toward a Petro-Developmental State? Merits and demerits of the Chadian rentier state.
Authors: Seign-goura Yorbana
Published: March 2023

The discovery of oil in Chad in the 1960s and its subsequent exploitation triggered the idea by international institutions that oil extraction would lead to sustainable development. Furthermore, Chad in tackling the resource curse would use rents to solve social, economic and security challenges on its territory. I argue that the state is the main actor in the resource curse, and its power derives rents from natural resources extraction. The curse emerges under local or international institutional pressures even if political outcomes are contextual and based on local norms. Drawing on theories of rentier state and developmental state, this paper seeks to critically explore local and international pressures that pull the state towards rentier behaviors resulting in poor local development outcomes.
Acciones del acreedor frente al administrador de la sociedad de capital distintas a la prevista en el artículo 367 de la Ley de sociedades de capital
Authors: Echeverría Echeverría Gaspar
Published: March 2023

La mayoría de los estudios relativos a las acciones del acreedor frente al administrador de la sociedad de capital se ciñen al supuesto de responsabilidad previsto en el artículo 367 de la Ley de sociedades de capital (LSC), referido al administrador que asume obligaciones en nombre de la sociedad habiendo incumplido el deber de promover la disolución o el concurso de acreedores de la compañía. Pero existen otros supuestos en los que el impago obedece a comportamientos antijurídicos y culpables del administrador distintos al contemplado en el citado precepto. Piénsese, por ejemplo, en el administrador que contrae una deuda cuando la sociedad es solvente, pero a sabiendas de que no podrá abonarla a su vencimiento; o cuando, aun siendo imprevisible la posterior insolvencia, esta hubiera sido provocada por su negligente actuación. También cabe pensar en el administrador que incumple, injustificadamente, la obligación de gestionar el pago de una deuda líquida, vencida y exigible, cuando la sociedad es solvente, sobre todo si, con posterioridad, dicha sociedad deviene en estado de insolvencia eliminando las expectativas de cobro del acreedor. Tales supuestos son objeto de estudio en este artículo, que propone fundamentar la reclamación frente al administrador en el régimen general de responsabilidad previsto en el artículo 236 de la LSC.
Esta propuesta no es ajena a la reticencia que se advierte en el ámbito forense a declarar la responsabilidad del administrador por deudas de la sociedad en supuestos distintos al contenido en el artículo 367 de la LSC, por lo que el trabajo contiene un análisis crítico de alguno de los argumentos que de manera recurrente esgrimen las resoluciones judiciales para eximir de culpa al administrador.
Organizational and legal aspects of the activities of the Perm District Commission of the V. I. Lenin Foundation in the field of prevention of homelessness and juvenile delinquency
Authors: Брылева Е.А. , Васева И.С.
Published: March 2023

Статистические данные свидетельствуют, что детская безнадзорность в настоящее время остается достаточно актуальным явлением и является одной из причин совершения противоправных деяний несовершеннолетними и в отношении них. Предметом изучения выступает отчет о деятельности Пермской окружной комиссии фонда им. В. И. Ленина. Целью исследования является исторический анализ борьбы с детской беспризорностью в 20-ые годы прошлого столетия, а также выявление положительных традиций, которые могут быть использованы на современном этапе. В работе использовались исторический, статистический методы, методы дедукции и индукции. По результатам исследования сделаны выводы о необходимости привлечения некоммерческих организаций к решению вопросов детской безнадзорности; целесообразности использования опыта Пермской окружной комиссии фонда им. В. И. Ленина для преодоления данного социального явления.

Statistical data show that child neglect currently remains a fairly relevant phenomenon and is one of the reasons for the commission of illegal acts by minors and against them. The subject of the article is a report on the activities of the Perm District Commission of the Foundation. V. I. Lenin. The purpose of the study is a historical analysis of the fight against child homelessness in the 20s of the last century, as well as the identification of positive historical traditions that can be used at the present stage. The work used historical, statistical methods, methods of deduction and induction. Based on the results of the study, the authors give conclusions about the need to involve non-profit organizations in resolving issues of child neglect; the expediency of using the experience of the Perm District Commission of the V. I. Lenin Foundation to overcome this social phenomenon.
The use of the Astra Linux operating system in the activities of employees of the penal system of the Russian Federation: opportunities and problems
Authors: Чураков Д.Ю. , Горященко И.С. , Хван Т.С. , Истомина И.А.
Published: March 2023

Актуальность применения программных средств, входящих в единый реестр российских программ для электронных вычислительных машин и баз данных, в том числе и отечественного офисного программного обеспечения, продиктована необходимостью использования разработок, не содержащих зарубежных систем и патентов. Предметом исследования является отечественное офисное программное обеспечение, используемое в деятельности работников уголовно-исполнительной системы Российской Федерации. Цель исследования – рассмотрение возможности использования такого программного обеспечения и выявление проблем, возникающих при переходе на отечественное офисное программное обеспечение. В результате проведенной работы проанализированы возможности применения операционной системы Astra Linux для использования в служебной деятельности работников уголовно-исполнительной системы и предложен аналог MS Office – кроссплатформенный и свободно распространяемый офисный пакет с открытым исходным кодом LibreOffice, который имеет свои преимущества. Для осуществления комфортного режима запуска кроссплатформенных систем под управлением операционной системы Astra Linux авторами рекомендуется ис- пользовать специализированное программное обеспечение контейнеризации, например Docker. Практическое значение результатов работы заключается в ознакомлении работников уголовно-исполнительной системы с возможностями операционной системы Astra Linux и применением ее в повседневной деятельности.

The relevance of using software, included in the unified register of Russian programs for electronic computers and databases, as well as domestic office software, is dictated by the need to use developments that do not contain foreign systems and patents. The subject of the study is domestic office software used in the activities of employees of the penal system of the Russian Federation. The purpose of the study is to consider the possibilities of using such software and to identify problems that arise when switching to domestic office software. As a result of the work carried out, the possibilities of using the Astra Linux operating system for use in the official activities of employees of the penal system were analyzed and an analogue of MS Office was proposed – a cross-platform and freely distributed open source LibreOffice office suite, which has its own advantages. To implement a comfortable launch mode for cross-platform systems running the Astra Linux operating system, the authors recommend using specialized containerization software, such as Docker. The practical significance of the results of the work is to familiarize the employees of the penal system with the capabilities of the Astra Linux operating system and its use in everyday activities.
The effectiveness of EHF therapy in patients with malignant neoplasms suffering from chronic pain syndrome
Authors: Litvinov G. E. , Smychek V. B. , Halinouskaya N. V. , Evseenko N. A. , Lapin A. V.
Published: March 2023

Objective. To evaluate the effectiveness of extremely high frequency (EHF) millimeter range electromagnetic radiation (EMR) of low intensity in patients with malignant neoplasms suffering from chronic pain syndrome (CPS).

Materials and methods. The study included 60 patients with diagnosed malignant neoplasm (MN) who were treated in a palliative care unit. They were divided into 2 groups. The main group consisted of 30 patients who underwent additional EHF-exposure with a course of 10 sessions of 15 minutes simultaneously with the main therapeutic measures. The comparison group consisted of patients who did not undergo electromagnetic exposure 30 people. Questioning was conducted twice: on the 2nd and 14th days of treatment. Treatment efficiency was assessed using standardized questionnaires.

Results. The analgesic effect of additional use of EHF therapy with a fixed frequency of 53.534 ± 0.015 GHz in patients with MN was significantly higher than the analgesic effect of standard treatment. In particular, there was an increase in mobility, as well as a decrease in depression and reactive anxiety.

Conclusion. The additional use of EHF therapy in patients with MN provides the advantage of improving quality of life by reducing CPS, improving psychological well-being and improving the ability to move independently.
State of local immune in phegmon of the maxillofacial region and neck on the background local photodynamic therapy
Authors: Cherniak L. A. , Harelik P. V. , Haretskaya M. V. , Sheibak V. M.
Published: March 2023

Objective. To study the effect of local photodynamic therapy (PDT) on local immunity in patients with maxillofacial region and neck phlegmonas.

Materials and methods. The study included 62 patients with phlegmon of the maxillofacial region and neck. Two groups of patients were formed. Patients of the 1st group were treated locally according to the traditional methods. Patients of the second group additionally underwent local PDT on the background of the complex of traditional therapeutic measures.

Results. Under the influence of local PDT with the preparation «Fotolon» in patients with maxillofacial region phlegmonomas in the postoperative wound we observed activation of phagocytosis, an increase in the population of CD3 + T-lymphocytes, subpopulation CD4 + T-helper, immunoregulatory index (IRI) with a simultaneous decrease in the level of CD8 + T-lymphocytes, The decrease of CD25+ activated Tand B-lymphocytes carrying the receptor for interleukin 2, and CD95+ activated Tand B-lymphocytes carrying the Fas-receptor, the decrease of complement activity, circulating immune complexes (CIC), IgM, IgA levels with an increase of IgG.

Conclusion. Local PDT activates local immunity in patients with maxillofacial and neck phlegmons. Exposure to PDT causes a more balanced immune system response by increasing the innate immune response in patients and a pronounced immunological reactivity in the region of the postoperative wound.
Determination of Helicobacter pylori resistance to clarithromycin in biopsy samples of gastric mucosa using TaqMan® MGB probes
Authors: Voropaeva A. V. , Borsuk A. D. , Shevchenko N. I. , Martynenko S. M.
Published: March 2023

Objective. To study primary resistance of H. pylori to clarithromycin in residents of Gomel region by real-time polymerase chain reaction (PCR RT) using TaqMan® MGB probes.

Materials and methods. The study included 184 patients diagnosed with gastritis and duodenitis, K29, median age 48.5 years (25% and 75% were 37 and 61 years old). According to the patients’ questionnaires, no clarithromycin-based eradication therapy was administered. To determine the resistance of H. pylori to clarithromycin, a PCR RV method using TagMan® MGB probes was used.

Results. All 184 tested DNA samples were positive for the Rnase P gene (ICS) and were considered in further analysis (Ct, HEX 20.20-34.14). DNA from the cagH gene (Ct, FAM 21.26-33.04), indicating infection with the bacterium, was confirmed in 152 samples (82.6%). DNA from the 23SrRNA gene (point mutations A2142G and A2143G) was detected in 16 of 152 DNA samples 10.5 % (Ct, Hex 20.24-31.17). The positive control samples had characteristic curve growth in the corresponding detection channels; no curve growth was observed in the negative samples.

Conclusion. The primary resistance of H. pylori to clarithromycin in the residents of Gomel region was 10.5%, and the use of triple first-line eradication therapy, including PPIs, amoxicillin and clarithromycin, as empirical in this region is consistent with the Maastricht III-VI recommendations and Decree of the Ministry of Health of the Republic of Belarus of 01.06.2017 № 54: clinical protocol “Diagnosis and treatment of patients with digestive diseases.” The use of PCR RT using TaqMan® MGB probes is justified to determine the resistance of H. pylori to clarithromycin, to prescribe individualized treatment and to evaluate the effectiveness of eradication regimens.
Experience of Klebsiella pneumoniae genome sequencing using the short read method on the Illumina platform
Authors: Shaforost A. S. , Ziatskov A. A. , Voropaev E. V. , Osipkina O. V. , Voropaeva A. V. , Bonda N. A. , Stoma I. O.
Published: March 2023

Objective. To review the main stages of Klebsiella pneumoniae genome sequencing using the Illumina short-read method and describe the peculiarities of sample library preparation and analysis of the obtained data.

Materials and methods. Deoxyribonucleic acid (DNA) for high-throughput sequencing was isolated from Klebsiella pneumoniae cultures. Sample preparation was performed according to the manufacturer’s instructions for the Nextera XT DNA Library Prep kit. Sequencing was performed on an Illumina MiSeq platform using a 2x151 cartridge. Genome assembly to the contigs was performed using the SPAdes Genome Assembler application on the Illumina BaseSpace Sequence Hub service and a set of programs in a Linux environment. The quality of genome assembly was assessed using the QUAST service.

Results. Genome sequencing of K. pneumoniae culture samples was performed, followed by an evaluation of the quality of the launch, assembly of the genome, and determination of its main parameters.

Conclusion. The main steps of K. pneumoniae genome sequencing have been considered using the short-read method on the Illumina platform. The main parameters for assessing the quality of sample preparation, launch and genome assembly are described.
Antioxidant and antimicrobial activities of four medicinal plants from Algeria
Authors: Bellik Yuva , Mekhoukh Nasreddine
Published: March 2023

Medicinal plants are used in folk medicine to cure several human diseases. This work was designed to evaluate the antioxidant and antimicrobial activities of different extracts of Globularia alypum, Dittrichia viscosa, Juniperus oxycedrus, and Retama sphaerocarpa. The total phenolic content (TPC), the total flavonoid content (TFC), and the condensed tannin content (CTC) were determined spectrophotometrically. The antioxidant activity was tested using TAC, DPPH and reducing power assays. The agar diffusion method was used to determine antimicrobial activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa) and one fungus (Candida albicans). J. oxycedrus acetone extract showed the highest extraction yield (35.56±0.45%), TPC (504.96±14.82 mg GAE/g DE) and TFC (43.91±0.87 mg QE/g DE). The same extract exhibited the highest TAC (350.67±6.05 mg GAE/g DE) and was the most effective against the DPPH free radical (IC50 = 0.21±0.01 mg/mL). In contrast, the J. oxycedrus methanol extract showed the highest reducing power (A0.5 = 0.39 ± 0.09 mg/mL). All extracts tested showed antibacterial and anticandidal activities at different concentrations. The best antimicrobial effect was also observed with the acetone extract of J. oxycedrus against P. aeruginosa (26.77±0.06 mm), B. cereus (17.16±0.08 mm), E. coli (15.84±0.04 mm), and C. albicans (21.36±0.11 mm), while the ethanol extract of D. viscosa was the most active against S. aureus (24.54±0.03 mm). The results of this study provide a scientific basis for the traditional use of these local plants and demonstrate their potential as sources of natural antioxidant and antimicrobial bioactive compounds.
Metal(II) triazole complexes: Synthesis, biological evaluation, and analytical characterization using machine learning-based validation
Authors: Arshad Muhammad Yousaf , Rashid Aqsa , Mahmood Faisal , Saeed Salaha , Ahmed Anam Suhail
Published: March 2023

The synthesis of many transition metal complexes containing 3,5-diamino-1,2,4-triazole (Hdatrz) as a ligand with different counter anions Br⎺, Cl⎺, ClO4⎺ and SO42- has been studied extensively, but the chemistry of transition metal nitrate and acetate compounds and their reactivity are relatively unexplored. In this research work, two new series of metal(II) complexes (M = Ni, Co, and Zn) {[Ni3(Hdatrz)6(H2O)6](NO3)6 (1), [Co3(Hdatrz)6(H2O)6](NO3)6 (2), [Zn3(Hdatrz)6(H2O)6](NO3)6 (3), [Ni3(Hdatrz)6(H2O)6](OAc)6 (4), [Co3(Hdatrz)6(H2O)6] (OAc)6 (5) and [Zn3(Hdatrz)6(H2O)6](OAc)6 (6)} have been synthesized. These synthesized complexes were characterized by various physicochemical techniques such as UV-vis spectroscopy, Fourier transform infrared spectroscopy, and magnetic susceptibility measurements. All six complexes were found to be trinuclear and bridged through the Hdatrz ligand. Spectral data suggested a distorted octahedral environment around the central metal ions in these complexes. It also revealed that the NH and OH groups are involved in hydrogen bonding. These complexes were tested against the fungal strains Colletotrichum gloeosporioides and Aspergillus niger. These synthesized complexes have not been observed to have antifungal activities. The machine learning K-nearest neighbours evaluates the analytical characteristics and solubility behavior of the metal complexes. Machine learning models provide results with 75% precision.
Orange to red emissive aldehyde substituted donor-π-acceptor phenothiazine derivatives: Optoelectronic, DFT and thermal studies
Authors: Mantur Shivaraj , Patil Mallikarjun Kalagouda , Nadaf Afra Quasar Abdul Rasheed , Najare Mahesh Sadashivappa , Yaseen Mohammed , Nesaragi Aravind Raviraj , Inamdar Sanjeev Ramchandra , Khazi Imtiyaz Ahmed , Kamble Ravindra Ramappa
Published: March 2023

A new class of probes was synthesized using a simple and efficient synthetic protocol. These compounds (PTZ-6(a-e)) have the phenothiazine (PTZ) moiety as the electron donor (D) and substituted aldehydes along with the acrylonitrile group, which acts as the electron acceptor (A), thus making D-π-A push-pull system. The structures of the newly synthesized series of small organic target molecules PTZ-6(a-e) were investigated and confirmed by spectros-copic techniques. The optical/solvatochromic properties were studied in detail by UV-vis absorption and fluorescence spectroscopy, because the molecules have shown good solubility in organic solvents. The density functional theory (DFT) model with the CAM-B3LYP function is utilized to study the photophysical properties of the probes, as these probes exhibited orange-to-red emission. Optical band gap values ranged from 2.32 to 2.50 eV, and these probes exhibited good thermal stability with a melting temperature of 136 to 198 °C and a T5d temperature range from 335 to 354 °C. The cyclic voltammetry study confirms that the Eoxonset values of the target compounds are 0.80 eV. The quantum yields (Φ) of the probes are measured experimentally in ethanol and the Stokes shifts are observed to be in the range of 4846-9430 cm-1. The results displayed that novel (D-A-D) chromophores could play an important role in organic optoelectronics.
Molecular and crystal structure characteristics of 2-phenylaminotetrahydro-1,3-thiazepine hydrochloride and 2-phenyliminohexahydro-1,3-thiazepine
Authors: Umirov Mukhriddin , Eshimbetov Alisher , Ashurov Jamshid , Turgunov Kambarali , Khodjaniyazov Khamid
Published: March 2023

The current research includes the synthesis and crystallographic characterization of 2-phenylaminotetrahydro-1,3-thiazepine hydrochloride (HPAT) and 2-phenyliminohexa- hydro-1,3-thiazepine (PIT) compounds. 2-Phenylaminotetrahydro-1,3-thiazepine hydro-chloride was synthesized by cyclization of 1-(4-hydroxybutyl)-3-phenylthiourea in an acidic condition. The second compound, 2-phenyliminohexahydro-1,3-thiazepine, was obtained by neutralizing 2-phenylaminotetrahydro-1,3-thiazepine hydrochloride with sodium hydrocarbonate. Both compounds were characterized by the single-crystal X-ray diffraction method. Crystal data for C11H17N2OClS (HPAT): orthorhombic, space group P212121 (no. 19), a = 4.97183(14) Å, b = 15.1169(4) Å, c = 17.7376(5) Å, V = 1333.14(6) Å3, Z = 4, μ(CuKα) = 3.859 mm-1, Dcalc = 1.299 g/cm3, 9243 reflections measured (7.684° ≤ 2Θ ≤ 152.042°), 2749 unique (Rint = 0.0314, Rsigma = 0.0255) which were used in all calculations. The final R1 was 0.0351 (I > 2σ(I)) and wR2 was 0.0911 (all data). Crystal data for C11H14N2S (PIT): monoclinic, space group P21/n (no. 14), a = 9.6303(9) Å, b = 9.8938(6) Å, c = 11.5627(9) Å, β = 103.419(8)°, V = 1071.62(14) Å3, Z = 4, μ(CuKα) = 2.357 mm-1, Dcalc = 1.279 g/cm3, 3938 reflections measured (10.798° ≤ 2Θ ≤ 152.328°), 2172 unique (Rint = 0.0288, Rsigma = 0.0330) that were used in all calculations. The final R1 was 0.0431 (I > 2σ(I)) and wR2 was 0.1219 (all data). The asymmetric unit of HPAT contains one protonated amine, one chlorine anion, and one water molecule. Chlorine anion and water molecules play the role of the bridge in chain formation along the a- and b-axis through H-bonds with N-H hydrogen atoms. Furthermore, the Hirshfeld surface analyses are performed to determine the nature of the intermolecular contacts stabilizing the crystal structures of 2-phenylaminotetrahydro-1,3-thiazepine hydrochloride and 2-phenyliminohexahydro-1,3-thiazepine.
Relationship of Self Efficacy with Foot Care Behavior in Diabetes Mellitus Patients
Authors: Rizana Novia , Andala Sri , Fitria Nanda , Sari Trisna , Anggraina Deva
Published: March 2023

One of the main steps in saving the feet of diabetics is to take preventive measures in the form of foot care. Self-efficacy is one of the factors that can support the success of foot care in diabetics. This study aims to determine the relationship between self-efficacy and foot care behavior in patients with diabetes mellitus. The research method is quantitative with a cross-sectional approach. The sampling technique in this study is purposive sampling with a sample of 110 respondents. Data was collected using the Foot Care Confident Scale (FCCS) and Nottingham Assessment of Functional Footcare (NAFF) questionnaires. Data analysis in this study using the chi-square test. The results showed that 67 respondents (60.9%) had high self-efficacy and 43 respondents (39.1%) had low self-efficacy, 59 respondents (53.6%) had good foot care behavior, and 51 respondents (46.4%) had poor foot care behavior. The results of the chi-square test obtained a P-value of 0.000 < α = 0.05, which means that there is a relationship between self-efficacy and foot care behavior in patients with diabetes mellitus. It can be concluded that there is a positive relationship between self-efficacy and foot care behavior in diabetes mellitus patients at the Gandapura Public Health Center, Bireuen Regency. It is recommended that health workers can provide health education about foot care regularly in order to increase self-efficacy in people with diabetes mellitus.