bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of surgical rehabilitation of the top parts of the gastroenteric canal in patients with duodenogastroesophageal reflux
Authors: Trynov S. N. , Gibadulin N. V. , Gibadulina I. O.
Published: June 2020

Are presented results of clinical use of an original way of strengthening antireflux function pyloric sphincter at patients expressed duodenogastroesophageal reflux. The expediency of performance of surgical rehabilitation esophagogastroduodenal canal, including selective proximal vagotomy, correction chronic duodenal obstruction, strengthening antireflux functions of the gatekeeper and formation the mechanism cardium therefore optimum anatomo-physiological conditions for normalization of processes of digestion are created is proved.
Psychopharmacotherapy efficacy in patients with disorders of depressive spectrum depending on some peculiarities of prehospital period
Authors: Shmunk Ye. V. , Kornetov N. A.
Published: June 2020

Most of patients with disorders of depressive spectrum are observed in primary care (PC) and take psychotropic medications that influence the course of depression. Patientns who took tranquilizers in PC demonstrated higher level of anxiety. Those who took antidepressants had more significant reduction of atypical depressive symptoms. Futher investigations are necessary.
Ultrastructural changes of mucous membrane maxillary sinus at patients by odontogenic sinusitis
Authors: Baidik O. D. , Shilov M. V. , Dolgun D. A. , Biritskaya Ye. V. , Logvinov S. V.
Published: June 2020

Features of ultrastructure of a mucous membrane of maxillary sinus are investigated at odontogenic sinusitis depending on the reason and prescription of disease. It is established, that the deepest destructive changes are found out in patients with oroantral message and stay in a sinus root material on a basis of zinc-oxidevgenol paste.
Peculiarities of in-depth medical examination of servicemen of the Tomsk Military Medical Institute with the use of prenosological diagnosis techniques
Authors: Bylkov E. S.
Published: June 2020

To study the state of health of students during the in-depth medical examination with the use of prenosological diagnosis techniques, 702 servicemen have been examined by the standard technique using the Apanasenko express assessment of the physical health (1987). All the examined people were divided into three groups: 162 people with the low level of physical health, 258 people with the middle level, and 282 people with the high level. The health group was assigned by the expert resolution of institute therapists. The group with the low level of physical health included 162 servicemen. The low level of physical health is most characteristic of servicemen having chronic diseases (85.7%) and sickly with acute diseases (36%). The fraction of healthy and practically healthy people in the group with the low level of physical health was 19.7 and 29.0%, respectively. The technique of prenosological diagnosis is the most simple and informative method to study somatic health for the following correction.
Quality of drinking water and health of population in the Republic of Altai
Authors: Yarkina T. V. , Volkotrub L. P.
Published: June 2020

The influence of the chemical composition of water in the Republic of Altai (RA) on medical-demographic indices has been studied. It has been found that the water is poorly mineralized, the fluorine content in it is three times lower than the optimal one, and the pollution of the water with toxicants 3.3—4.6 times exceeds the maximum permissible level. Significant correlation coefficients (р < 0.05) are revealed between the excess over the maximum permissible concentrations of toxicants in the drinking water and infant mortality; total chemical pollution of water and total adult morbidity, optimality index of the drinking water and morbidity with new-onset circulatory diseases, fluorine content in the drinking water and the level of congenital defects, water mineralization and hardness and the oncological mortality level in RA rural regions.
Tendency of the population aging and the elder groups’ people health in Tomsk Region
Authors: Lozhkina T. Yu.
Published: June 2020

The statistical rates of population health both in Russian Federation and Tomsk Region demonstrate the high morbidity level among the persons from 60 years and older, which are three times and more exceeding the analogous rates of the employers. The predominance of chronic forms of pathologies among the elder age people, which are aggravated by the natural (physiological) aging processes, influence structural and quantitative components of health care system.
Prognostic aspects of modeling hemogram parameters dynamics at iron-deficient erythropoiesis correction
Authors: Baranovskaya I. B. , Onishchuk S. A.
Published: June 2020

Application of mathematical modelling in practical hematology allows to receive new data on process of treatment under the analysis of changes of variable and mathematical parameters. By means of S-functions dynamics of the some erythrocytic and reticulocytic parameters gemogram at 5 patients on a background of treatment iron-deficiency anemias has been investigated Expression of functional dependences in the form of approximated curves has allowed to execute processes interpolation and extrapolation, that is important for the decision of the questions connected with forecasting of change of parameters gemogram and results of treatment.
Peculiarities of bioelectric activity of brain in Khakassia people with different types of temperament
Authors: Karavayeva Ye. N. , Savchenkov Yu. I.
Published: June 2020

The electroencephalography (EEG) method has been used to study peculiarities of the bioelectric activity of brain in Khakassia native people (Russian and Khakas of any sex) representing different types of temperament. The Rusalov questionnaire was used. The background EEG was recorded, as well as the EEG with the application of the standard set of trigger samples. The data obtained have shown no general differences between Russians and Khakases in the bioelectric activity of brain. However, the comparison of EEG data with the data of psychological testing revealed some peculiarities. In Khakas men in the left cerebral hemisphere and in women in the both hemispheres, the intensification of the amplitude in the α-region is observed in groups with high-emotional middle-active and low-emotional middle-active types of temperament. This confirms the assumption on the existence of genetically determined peculiarities of the nervous system characteristic of Khakases.
Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
Authors: Rachkovskiy M. I. , Goncharova I. A. , Beloborodova E. I. , Beloborodova Ye. V. , Gruzdeva Ye. G. , Alekseyeva A. S. , Puzyryov V. P.
Published: June 2020

With the purpose of studying of association of polymorphic variants of genes glutathione S-transferases pi and mu (GSTP1 and GSTM1) with survival rate sick of liver cirrhosis (LC), it is lead uniinstantly research of 189 sick of LC of a virus (HBV, HCV, H V+H V) and an alcoholic etiology. Have been В С compared a frequencies of allocation of polymorphic variants of genes GSTP1 and GSTM1 between the died and persisted patients for the season 4 years. With greater survival rate of sick of LC associated: presence of genotype АА of gene GSTP1 (χ 2 Pearson, р = 0,008) and «null» genotype GSTM1 (χ 2 Pearson, р = 0,027). Chances of development of a lethal outcome at sick of LC with presence of genotypes GG and AG on gene GSTP1 in 2,5 times above, than at patients with genotype АА. Presence of active gene replica GSTM1 enlarges chances of development of a lethal outcome in 2 times. The received results testify to necessity of the count of genetical factors for the forecast of LC.
Morphological changes of a retina of an eye at influence by laser radiation of threshold intensity with wavelenght 450 nm and their correction by synthetic dipeptid
Authors: Anikina Ye. Yu. , Potapov A. V. , Varakuta Ye. Yu. , Bukhtiyarov I. V. , Kislyakov Yu. Yu. , Prokofiyev A. B. , Kamenkova Ye. A. , Logvinov S. V.
Published: June 2020

The analysis of alterations retina of during exposure of threshold laser intensity and opportunities to correct it by synthethic dipeptid. The material and method: 23 rabbits were included in the experiment. Recived matherial was investigated with help of light and electron microscopy. All layers of retina were damaged during laser exposure. The usage of synthethic dipeptide reduced laser damage. Synthethic dipeptid have retinoprotection abilities.
Participation of reactive oxygen species in regulation of Са2+ - activated К + channels of erythrocytes
Authors: Trubacheva O. A. , Kremeno S. V. , Petrova I. V. , Sitozhevsky A. V. , Gruzdeva O. V. , Ivanov V. V. , Suslova T. Ye.
Published: June 2020

In this study, we investigated the effects of preincubation with the reactive oxygen species-generating system xanthine oxidase/xanthine on Ca2+-dependent potassium permeability of erythrocyte membrane. The increase of intracellular calcium concentration in presence of calcium ionophore A23187 led to erythrocyte membrane hyperpolarization due to opening of Ca2+-activated potassium channels. Erythrocyte membrane potential was recorded via measurement of pH of the incubation medium in presence of prothonophore. Incubation of erythrocytes with xanthine (100 µmol)/ xanthine oxidase (10 mU/ml) mixture resulted in significant loss of amplitude and rate of hyperpolarization response and also loss the rate of membrane potential restoration. These effects can be caused by hydrogen peroxide, one of products of reaction of xanthine oxidase/xanthine.
Problem of diagnostics of deterioration in bone strength in children
Authors: Zyatitskaya A. L.
Published: June 2020

The most part of the bone mass is formed between 10 and 14 years. The age of achievement of the peak bone mass in different parts of skeleton varies from 17 to 30 years. Low values of the peak bone mass are a significant risk factor, since the formed bone substance is expended later. Measures aimed at the early diagnostics, revealing of risk groups, and prophylaxis of reduction of the bone strength in children will favor the gain in health of children population and in the life quality in both children and adult people and will provide the economy of material resources.
Modern principles of treatment of the serious multisystem injuries
Authors: Shteinle A. V.
Published: June 2020

The analytical survey is concerned with the organizational aspects of the integrated study and thorough investigation of the problem of treatment of serious mechanical injuries.
Structural features of a pathology and functional condition of a thyroid gland in patients with a chronic virus hepatites В and С
Authors: Galyan Ye. V. , Kravets Ye. B. , Latypova V. N. , Damdindorj D.
Published: June 2020

Studying a condition thyroid systems according to objective survey, ultrasonic inspection, research thyroid the status at patients with the verified diagnosis a chronic hepatites B and C. 50 patients (29 men and 21 women, in the age of from 18 till 59 years, (middle age (22,3 ± 3,8) year) is lead, average duration of disease (3,4 ± 1,2) year with a chronic hepatites B and C. structure of a pathology of a thyroid gland, clinical current autoimmune pathology on a background of a hepatites is estimated B and C, parameters of a functional condition thyroid systems at the given group of patients are investigated. It is revealed, that the virus of a hepatites C negatively influences a condition thyroid systems and proves role НСV as one of factors in development autoimmune pathology.
Neuritis retrobulbaris of multiple sclerosis patients
Authors: Ignatova Yu. N. , Smagina I. V. , Gridina A. O. , Sidorenko V. A. , Popovtseva A. V. , Smirnova O. V. , Yelchaninova S. A. , Fedyanin A. S.
Published: June 2020

According to the anamnesis data 38% of multiple sclerosis patient population had neuritis retrobulbaris as the first clinical symptom. The examination of visual evoked potentials detected that 88% of patients who had suffered from neuritis retrobulbaris earlier, and 19% of those, who had not, had changes revealing possible subclinical demyelinization of a visual nerve.
Problems of adaptation to conditions of the educational environment for civil and military students
Authors: Denisov N. L.
Published: June 2020

Factors of adaptation to conditions of the educational environment for civil and military students have been studied. By the end of the education, the number of military students classified to the 1st health group increased by 5% and the number of military students classified to the 3rd health group decreased by 3%. Among civil students, the number of persons classified to the 1st health group decreased by 4%. The state of students’ health is significantly affected by social and psychological factors related to the education, in particular, academic load, disturbed sleep, psychoemotional stresses, relations with teachers. In formation of students’ groups, the emotional component is especially important for undergraduates, while the cognitive and behavioral components are important for graduate students.
The characteristic vegetative control heart activity by vertigo central genesis
Authors: Grebenyuk O. V. , Novikova N. S. , Alifirova V. M.
Published: June 2020

We investigate vegetative regulation heart activity by 15 patients with temporal lobe epilepsy and 15 with syndrome vegetative dysfunction. We detect increase sympatic tonus at rest and low arousal sympatic part by realization orthostatic test by patient with vertigo central genesis as against with healthy. It is our belief that detect disturbance related to implication in pathological process suprasegmental part statokinetic analyzator.
Association of the stroke with cardiovascular risk factors at patients type 2 diabetes in Altai Region
Authors: Leonova N. V. , Nazarenko N. V. , Chumakova G. A. , Pushkaryova S. V. , Pergaeva Yu. S. , Vigel A. K.
Published: June 2020

Аmong patients DM of type 2 (DM 2) Altay territories the stroke is at the bottom of death in 4,1 times more often, than among the edge population. A research objective: to estimate and compare a role of various risk factors (RF) in occurrence of a stroke at patients DM 2 sick of a diabetes according to register DM 2. Assumed RF in the basic group (patients prevalence was compared to a stroke) and in comparison group (patients without a stroke) with calculation of the odds ratio of development of a stroke. Were compared statistically significant RF developments of a stroke 2005 and 2008. Studying RF of a stroke at patients СД of type 2 and work carrying out on decrease in force of their influence, has allowed to level influence of one of the most significant risk factors of development of a stroke in 2005, late diagnostics blood pressure that has resulted in 2008 in decrease in death rate from a stroke among patients DM 2 on 24,9% more than among the population of Altay territory.
Long-term results of embolization arteriovenous malformations with hystoacryl
Authors: Andreyeva Ye. S. , Panuncev V. S. , Ivanova N. Ye.
Published: June 2020

N-butyl cyanoacrylate (Hystoacryl) is one of the most frequently used glues for the treatment of cerebral arteriovenous malformation. However, long-term results of its treatment with Hystoacryl are insufficiently studied. 136 patients were examined. Catamnesis was (4 ± 1) year. The quality of life is reduced due to cognitive and motor disorders.
Morphological and biochemical markers of inflammatory reactions in a mucous membrane of bronchial tubes at the heavy form of a bronchial asthma and chronic obstructive disease of lungs
Authors: Gereng Ye. A. , Sukhodolo I. V. , Pleshko R. I. , Ogorodova L. M. , Akbasheva O. Ye. , Bukreyeva Ye. B. , Dzyuman A. N. , Kobyakova O. S. , Selivanova P. A. , Kremis I. S.
Published: June 2020

In the present research the complex cytologic and biochemical estimation of a condition induced sputum at 19 patients with the heavy therapeutic-sensitive form of a bronchial asthma and 18 patients with chronic obstructive disease of lungs is lead. Dominating morphological and biochemical markers of an asthma became the raised number of macrophages, lymphocytes, and eosinophils at decrease in functional activity neutrophil elastase and increases activation properties. Progressing of destructive and fibrous processes at patients with heavy form chronic obstructive pulmonary disease occurs on a background active neutrophil and lymphocytes reactions in a mucous membrane of bronchial tubes that proves to be true high activity elastase and falling of functioning proteinase inhibitor.
Significance of dermatoglyphics in criminalistic description of human appearance
Authors: Kalyanov Ye. V. , Mazur Ye. S.
Published: June 2020

Based on materials of combined anthropogenic enquiry of 2 620 men and 380 women, which included fingerprint and palmprint records, relations between dermatoglyphic and descriptive external characteristics have been studied with the aid of various statistical methods. The obtained data can significantly extend capabilities of expert examination concerning the criminalistic and medicolegal anthropometric identification in operational investigations.
Correction of disordered equilibrium function in students through exercise therapy
Authors: Davletiyarova K. V. , Soltanova V. L. , Kapilevich L. V. , Andreyev V. I.
Published: June 2020

The method of stabilography was used to study the equilibrium function in students with vascular heart diseases and diseases of musculoskeletal system going in for exercise therapy (ET). The organization of physical training with the use exercise therapy favors the normalization of the equilibrium function and coordination abilities, and the effect is more pronounced in the group of students with diseases of the musculoskeletal system.
Functional significance of polymorphism of ApoE and SOD2 genes in formation of chronic HCV infection
Authors: Semyonova N. A. , Ryazantseva N. V. , Novitsky V. V. , Dmitriyeva A. I. , Chechina O. Ye. , Bychkov V. A. , Moiseyenko I. P.
Published: June 2020

The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase genes and the corresponding genotypes were determined in healthy persons and chronic viral hepatitis type C patients of the Europeoid population of the Tomsk Region. For the analysis of polymorphism of these genes, we used modern genetic methods: polymerase chain reaction and polymorphism of lengths of restriction fragments. For the studied population, it was revealed that the polymorphism of apolipoprotein E and 2nd type superoxide dismutase genes correlates with the development of chronic viral hepatitis type C and with the fibrogenesis process.
Formation and biological role NO at an allergic inflammation
Authors: Kozina O. V. , Ogorodova L. M.
Published: June 2020

In the review ways and mechanisms of formation nitric oxide are considered. Effects metabolite nitric oxide in regulation of an allergic inflammation are analysed. The modern given participations nitric oxide in formation oxidative and nitrosative stresses, in regulation of the basic endocellular alarm ways, to realizations pro-and antiapoptosis effects.
Experience in teaching of doctors to computer technologies
Authors: Vorobeychikova O. V. , Novikova T. V.
Published: June 2020

The experience in teaching of doctors to using computer in course of medical and biological cybernetics at the faculty of professional skill SSMU is summarized. Characteristic properties of adult students are considered. The necessity of a special approach to teaching is proved. The method of composition and teaching of educational material takes into account a heterogeneity of groups and allows the students to get the needed skills.
Special aspects in tuberculosis teaching based on reviews of medical malpractice cases
Authors: Nekrasov Ye. V. , Filinyuk O. V. , Buinova L. N. , Kolokolova O. V. , Anastasov O. V. , Felker I. G. , Schegertsov D. Yu. , Yanova G. V.
Published: June 2020

In the educational program of the Chair of Tuberculosis and Pulmonology of Siberian State Medical University (Tomsk), there is a special consideration towards tuberculosis alarm, the ways of TB detection, diagnostics and differential diagnostics of pulmonary and extra-pulmonary TB. Moreover, there is an educational promotion of deontology and medical ethics questions to students and listeners of the Advance Training Faculty and the Post-graduate Professional Education Course. They also participate in review conferences related to causes and ways of prevention medical malpractice cases.
Information support for disease weight and chronic trend monitoring for children from distant areas of Tomsk Region
Authors: Sizov Ye. Ye. , Karas S. I. , Deyev I. A. , Kamaltynova Ye. M.
Published: June 2020

The unified modeling language is used to design a structurally functional model of an information-analytical system for assessment of the state of a disease for the early detection of children with the increased risk of serious states living at sparsely populated territories. Using this model and methods of structured programming, as well as client-server technologies along with a structured query language, it is possible to develop a territorially distributed on-line system, which uses a common information space and accumulates centrally data on the severity of a disease.
Chronic kidney disease in patients with psoriasis, chronic opisthorchiasis and at their combination
Authors: Kolosovskaya T. A. , Khardikova S. A. , Kalyuzhina Ye. V. , Surkova L. G. , Zamyshevskaya K. A. , Varlacheva K. A.
Published: June 2020

The aim of the investigation was to study of features of сhronic kidney disease in patients with chronic opisthorchiasis (CO), psoriasis (Ps) and their combination. Examination was performed on 360 patients with CO, 100 patients with Ps, 50 patients with Ps combinated CO and 30 healthy subjects. In addition to complete clinical and instrumental examination accepted in specialised clinic, biopsy of kidney was conducted. The interrelation of intensity of sclerous processes in kidneys and renoprival syndrome with duration of CO and activity of Ps was found. Dehelmintization with biltricid promoted improvement of functional state of kidneys.
Therapeutic effectiveness disorders of depressive spectrum depending on medical intreventions during prehospital period
Authors: Kornetov N. A. , Shmunk Ye. V.
Published: June 2020

Open clinical comparative assessment of therapy effectiveness of depressive spectrum disorders was carried out. We compared patients who began treatment in special psychiatric department and those who underwent different consultations, investigations and took medication in primary care before hospitalization. This investigation showed high effectiveness of therapy, reduction of depressive symptoms, improving of psychological state and increasing level of social adaptation in patients who didn’t contact with primary care settings.
Physiobalneotherapy possibilities in correction of infringements neurohumoral and the psychoemotional status at participants of confrontations
Authors: Levitsky Ye. F. , Zaitsev A. A. , Barabash L. V. , Smirnova I. N. , Levitskaya T. Ye.
Published: June 2020

The purpose of research was studying vegetative reactance, a hormonal background, an exchange of cholesterol, a bioradical homeostasis and psychoemotional status at participants of confrontations and an opportunity of not medicamentous correction of their infringements. 109 employees of the power departments which are repeatedly taken part operations are surveyed and treated. Сomplex purpose of radonic baths and mm-wave therapy renders more expressed positive influence on fractions of cholesterol of blood, and purpose of pearl baths and galvanizing of area of a collar — on a hormonal background, a condition of a bioradical homeostasis)that can form the basis of the differentiated approach to regenerative treatment has been revealed.
System for control over the detoxication process and the state of an organism for patients with surgical infection
Authors: Kemerov S. V. , Styopin D. A. , Koshel A. P. , Zherlova T. G. , Shipakov V. Ye.
Published: June 2020

The complexity of measures on detoxication of an organism is caused by the critical state of a patient against the background of multiple organ failure, disordered hemodynamics, pronounced changes of hemostasis, protein-energy deficiency, waterelectrolytic and acid-base disbalance. A new method is proposed for the treatment and control of the detoxication process. The positive effect of this method is caused by the syndrome-by-syndrome character of the therapy and the multilevel direction of the action. The proposed method involves all the interested organs and systems of an organism into the detoxication process.
Diagnostics of inflammatory tuboovarian complexes
Authors: Kokh L. I. , Balakshina N. G.
Published: June 2020

Objective differential diagnosis inflammatory tuboovarian complex in patients hospitalized following emergency visit were investigated. We examined and operated 123 patients with acute abdomen symptom hospitalized at the inpatient gynecology department Regional Clinical Hospital following emergency visit.
YРА therapy by a background resonance radiation in chronorehabilitation of patients with chronic cholecystitis in combination with chronic opisthorchosis
Authors: Poddubnaya O. A.
Published: June 2020

The chronobiological approach was used to improve indices of functional activity of the biliary excretion system and enhance the general efficiency of treatment at chronic cholecystitis in combination with chronic opistorhcosis. For this purpose, transverse galvanization of the eigatric area was carried out against the background of general health-improving procedures and the YРА therapy by the background resonance radiator after intake of herbal remedy (hepatosol). The treatment was carried out with allowance for the individual phase of the rhythm of activity of the biliary excretion system or with the use of a group approach with procedures prescribed in the rising (from 10:00 to 11:00) or declining (from 13:00 to 14.00) phase of the rhythm. The results obtained indicated that the chronophysiotherapy in patients chronic cholecystitis in combination with chronic opistorhcosis increase the efficiency of treatment, while the accessibility of this approach confirms its practical significance.
The condition of mental health of industrial enterprise’s workers according to the data of the preventive examinations
Authors: Balashov P. P. , Antukhov A. V.
Published: June 2020

789 industrial enterprise’s workers, having dangerous special conditions of work, were investigated by a questionnaire, containing 24 questions and statements about psychopathological symptoms. It was determined, that the risk factors of appearance of the psychopathological symptoms are a female sex, an age more than 40 years, a loss of spouse. The investigated factors of production (character, work experience, operating schedule, education) didn’t influenced on a frequency of appearance of the psychopathological symptoms.
Research of chemical and toxic properties of humic acids of low-moor woody-grassy type of a peat in Tomsk Region
Authors: Belousov M. V. , Akhmedzhanov R. R. , Gostischeva M. V. , Yusubov M. S. , Matveyenko A. V.
Published: June 2020

In article results of research of a chemical structure of humic acids of low-moor woody-grassy type of peat of Tomsk Region are resulted by methods of the elemental analysis and infra-red spectroscopy. In this work results of toxicological research of humic acids also are described: acute toxicity, pathomorphology and flow properties of blood. It is shown, that humic acids of low-moor woody-grassy type of peat represent connection with a high share aliphatic fragments submitted long connected by circuits, have a small degree benzenoid, contain active oxygen and itrogen-containing functional groups (carboxylic, hydroxyl, amides, amino groups). It is established, that humic acids at intragastric introduction are nontoxic substances. At intraperitoneal introduction of lethal dozes, the destruction of animals comes from acute intimate insufficiency, thus the cause of acute infringement hemodynamics can be negative influence of humic acids on flow properties of blood.
Clinical, laboratory and coagulation system of blood feachers in patients with viral liver cirrhoses associated with virus hepatitis B, C and D
Authors: Bogushevich S. A. , Chuikova K. I.
Published: June 2020

The research is devoted to study clinico-laboratory implications and indicators of coagulating system of blood at patiens with liver cirrhosis associated with virus hepatitises B, C and D. The group of 100 patients were analyzed. At patients combined the lesion of a liver viruses HCV and HBV met identical frequency with a HBV-infection (34%). The hepatocellular carcinoma is taped in 8% of cases. At 50 patients with a cirrhosis in subcompansation stage researches of coagulating system of blood have been carried out. According to the developed coagulogram consumption coagulopathy development became perceptible.
Formation of the pulmonary hypertension in patients with a liver cirrhosis
Authors: Kalachyova T. P. , Chernyavskaya G. M. , Beloborodova E. I.
Published: June 2020

The aim of the study was to ventilation function of lungs and echocardiography activities right and left ventricular, blood flow disorders in pulmonary artery in confront with clinical pictures and activities portal haemodynamics in patients with a liver cirrhosis. Established, that change structural-functional activities right and left parts of heart in a liver cirrhosis depend on to a great extent, to a weight of disease and to be accompanied raorganisation of a central haemodynamics and forming pulmonary arterial hypertension. Pulmonary arterial hypertension in close association with portal circulation of the blood and represented not rare complication of a liver cirrhosis.
Medical genetic study of population in rural districts of Buryatia Republic
Authors: Minaycheva L. I. , Nazarenko L. P. , Yeryomina Ye. R. , Tsyrenova V. B. , Salyukova O. A. , Fadyushina S. V. , Ayushina V. B.
Published: June 2020

Medical-genetic study of the population of 5 rural districts of Buryatia Republic has been performed. The number of investigative population was 114,6 thousands people. The 23, 9 and 8 nosological forms of autosomal dominant, autosomal recessive and Xlinked diseases were revealed, respectively. The hereditary pathology spectrum and the features of prevalence in the studied population were described.
Treatment of chronic heart failure with a very low dose of antibodies to C-fragment of type 1 angiotensin II receptor
Authors: Poponina T. M. , Noll Ye. S. , Poponina Yu. S. , Portnyagin B. F. , Simonova N. M.
Published: June 2020

The open randomized placebo-controlled prospective study was conducted; we documented improvement of global contractility and diastolic function of left ventricle, clinical and psychological status in 60 patients with chronic heart failure receiving a very low dose of antibodies to C-end fragment to AT1 receptors of angiotensin II for 6 months (Cardosten). The drug was well-tolerated.
Status of the homeostasis in patients with puberty uterine bleeding
Authors: Sotnikova L. S. , Nasyrova R. F. , Dygai A. M. , Novitsky V. V. , Beloborodova Ye. V. , Agranovich T. F.
Published: June 2020

In this article the analisis of homeostatic status in 590 patients with puberty uterine bleeding has being presented. We found the following systemic changes in studies of erythron, hormonal status, immunity and tonus vegetative nervous system.
Exocrinous function of pancreas in Crohn’s disease patients
Authors: Burkovskaya V. A.
Published: June 2020

The functional state of pancreas in patients with the Crohn’s disease was studied. In feces of patients with CD, irritable colon syndrome, and healthy persons, the daily fat amount was determined by the van de Kamer’s method and fecal elastase-1 was determined using the immune-enzyme test with monoclonal antibodies (EIA system of BioServ Diagnostics, Elastase 1-ELISA, Germany). The fecal elstase-1 level in absolute and relative values in patients with CD decreases statistically confidently as the main disease becomes more severe.
Population peculiarities found in the prevalence of chronic diseases of ear, nose and throat in rural adults in Khakass Republic
Authors: Kishteyeva V. A. , Kapustina T. A. , Burenkov G. I.
Published: June 2020

The article shows the indices of prevalence and structure in chronic othorhinolaryngologic pathology in rural native and alien people of Khakass Republic. The authors examined 2 023 subjects by random. The results of cross-section research revealed high prevalence of the pathology in Ear-Nose-Throat-organs in rural population of the republic irrespective of ethnic belonging. Comparative analysis of prevalence indices corresponding to the Europoids and the Khakasses determined the range of ethnic peculiarities in epidemiology of chronic diseases of ear, nose and throat.
Influence of Melatonin on the state of immunity at psoriasis
Authors: Dmitruk V. S. , Striga L. V.
Published: June 2020

The influence of the chronopharmacological scheme of treatment with the use of exogenous Melatonin in the form of the Melaksen drug on the immunity status of psoriasis patients has been studied. The study of the immunity status consisted in determination of the main Manchini classes of immunoglobulins A, M, G, the level of circulating immune complexes by the method of selective precipitation in 3% polyethylene glycol. In addition, we determined the subpopulation of lymphocytes carrying CD3, CD4, CD8, CD16, CD 25, and CD72 antigens by the immunofluorescent method. In has been found that Melatonin in psoriasis patients exerts the immunomodulatory action on the immune system at the combined treatment (due to an increase in the number of -lymphocytes with cytotoxic-suppressive properties at obvious signs of immune disbalance in the form of the increased ratio of Т CD4+ and CD8+).
Adsorption activity of raw material of perspective marsh-water plants of Western Siberia
Authors: Kelus N. V. , Babeshina L. G. , Dmitruk S. Ye. , Subbotina N. S. , Nikiforov L. A.
Published: June 2020

In order to find effective sorbents of herbal origin, we’ve studied adsorption properties of aerial dry raw materials of 31 marsh-water, medical perspective, plant species. It was found that 8 of those 31 exercises adsorption activity (Shpagnum species).
Influence of Essentiale and Succinic acid on liver bioenergetics in experimental Paracetamol intoxication
Authors: Korshunov D. A.
Published: June 2020

The influence of hepatoprotector phospholipid nature Essentiale and Essenciale combination with succinic acid on the metabolism of liver injury caused by Paracetamol in rats has been investigated. As a result of therapy was decreased Paracetamol hepatotoxicity — in the blood reduced the aminotransferases, alkaline phosphatase activity, bilirubin content, in liver homogenates decreased production of diene conjugates, Schiff bases and malondialdehyde. Essentiale improved the oxidative phosphorylation conjugacy without influence on liver mitochondria respiratory activity kinetic parameters. Combined application of Essentiale and succinic acid normalized the liver mitochondria respiratory function.
Methodic approaches to prediction of a positive corporate image of pharmaceutical organizations
Authors: Petrov A. G. , Knysh O. I. , Petrov G. P.
Published: June 2020

Methodic approaches to the prediction of a positive corporate image of pharmaceutical organizations are presented. A technique is developed for the prediction of a risk of loss of the corporate image. The technique includes the algorithm for construction of estimation and prediction tables and rules of their usage.
Psychophysiological characteristics of young schoolchildren in the learning dynamics
Authors: Polyashova N. V. , Soloviyov A. G. , Novikova I. A.
Published: June 2020

To study psychophysiological characteristics of young schoolchildren in the learning dynamics under the conditions of healthsafe learning process, 104 children of 1st to 4th classes were investigated. It has been found that in most young schoolchildren, the moderate extraversion, medium level of emotional tolerance, moderate general anxiety, and low physiological resistance to stress prevail among psychophysiological characteristics. At the end of the school year, children are characterized by the decreased efficiency, signs of chronic overwork, decreased positive emotions, and decreased adaptability. The most pronounced negative changes are characteristic of 4th -clss children, which is likely connected with the transition to the new stage of learning.
From the history of pharmacy in Sakha Republic (Yakutia)
Authors: Tarabukina S. M. , Dmitruk S. Ye.
Published: June 2020

This study presents historical information about pharmacy beginning, formation, development in one of the most severe and remote from the center regions of Russia. There is retrospective mention of pharmacists and chemists contributed to the basis and up-to-date system of medicine supplying of population in boundless territory former Yakutsk Region — Sakha Republic (Yakutia).
Realization apoptosis in nucleus sincythiotrophoblast villus of placenta at pregnant, transferred an aggravation of a herpes-virus infection depending on thecontents in homogenate placentae anneexin V
Authors: Lutsenko M. T. , Andriyevskaya I. A.
Published: June 2020

The reason of increase apoptosis in sincythiotrophoblast is suppression of activity ATP-ase, moving phosphatydilserin on an external membrane sincythiotrophoblast, and increase of quantity annexin V in homogenate placentae.
Mathematical modeling of the particularities of compensations of anemia by means of the appearing additional cell’s flow into peripheral blood
Authors: Svischenko V. V. , Stakhin N. A. , Khokhlov I. A.
Published: June 2020

For evaluation of the maximum values of the hemoglobin compensated by means of the appearing additional cell’s flaw into peripheral blood the method of mathematical modeling has been used.
Antitumor in vitro and in vivo effects of lipid composites of cisplatin and ferromagnetic nanoparticles capsulated by carbonic coating
Authors: Antipov S. A. , Feduschak T. A. , Kokorev O. V. , Gereng Ye. A. , Dambayev G. Ts. , Yermakov A. Ye. , Uymin M. A. , Khlusov I. A.
Published: June 2020

An investigation of in vitro and in vivo reaction of adenocarcinoma cells in conditions of direct contact with composites designed in a base of phospholipid concentrate, cisplatin and nanoparticles (diameter less than 10 nm) of iron capsulated by carbonic coating was the aim of paper. Their antitumor effect has been established to be conditioned by direct cytotoxic relatively elective action on malignant cell and, on the other hand, by stimulation of tumor node fibrosis. Proposed biotechnological approach that used low doses of cytostatic drug (1/10 LD50) and nanoferromagnetic particles (2 mg/kg) may be useful to design magnetocontrollable regimes for regional immuno(bio)therapy of cancer and its metastases.
EMG biofeedback and functional magnetic resonance imaging in the post-stroke rehabilitation (precise grip training)
Authors: Chernikova L. A. , Ioffe M. Ye. , Busheneva S. N. , Shestakova M. V. , Bilimenko A. Ye.
Published: June 2020

The mechanisms of reorganization of motor systems at the poststroke patients after rehabilitation were studied using the method functional magnetic resonance imaging (fMRI). At patients after standard rehabilitation therapy, irrespective of localization of stroke, the increase in intensity of the basic activity zones in sensomotor areas and in the field of a hemisphere of a cerebellum as for paretic, so for a healthy hand was revealed. At patients after EMG biofeedback training of the precision grip the reorganization of functional motor system consists in more significant increase of intensity of activation of the basic zones only in lesioned hemisphere; expressiveness of these changes did not depend on localization of stroke. The degree of restoration of movements of hand after EMG biofeedback training was authentically above, than after a course of standard rehabilitation therapy. Thus, fMRI and the clinical analysis have shown that EMG biofeedback training of the precision grip have the goal-directed and effective influence upon processes of functional reorganization of motor systems.
Dependence of dynamic of psychoautonomic criterions and characteristics features in biofeedback training sessions with temperament of patient
Authors: Redko N. G.
Published: June 2020

The paper presents the research of work on dynamic autonomic nervous system, anxiety and attention parameters with temperament characteristics — emotionality and activity in self-regulation training by game biofeedback. There are instructional advices of biofeedback training with temperament of patients.
The development and mastering of the skills of self-regulation in the course of game biofeedback: psychological analysis
Authors: Mazhirina K. G. , Jafarova O. A. , Pervushina O. N. , Redko N. G.
Published: June 2020

In this paper we present the results of the study of the characteristics of self-regulation skills development using game biofeedback, and psychological predictors of these skills’ mastering in the course of biofeedback training. Analysis of the psychological characteristics associated with/ restraining the learning of self-regulation during training is given. It was shown that the training based on computer biofeedback allows modifying self-regulation profiles of the subjects towards more effective ones. The steadiness of the skills was confirmed.
On the possibility of treatment of dorsopathy with chronic paine syndrome using the kinesiotherapy combination with multi-parametrer biofeedback
Authors: Tsirkin G. M. , Voroninskiy V. A. , Zinert A. Yu. , Shperling M. M. , Tseytlin A. A.
Published: June 2020

The paper describes the possibility of the increase of treatment efficiency in case of dorsopathy with chronic pain syndrome using the applied kinesiology combined with multi-parameter biofeedback.
Identity in heroin addiction and its modification in the course of alpha-stimulation biofeedback
Authors: Shubina O. S. , Melnikov M. Ye. , Zagoruyko Ye. N. , Skok A. B.
Published: June 2020

This paper is dedicated to multifactor evaluation of heroin addicts identity and its modification during neurofeedback (alphastimulating training). It was found that alpha-stimulating training induced specific changes in identity concerned self-perception and future planning. Modification of real identity during neurofeedback courses was investigated. It was shown potential of neurofeedback in the treatment of addictions.
Character of reorganizations of statistical structure of EEG components interactions in the course of biofeedback
Authors: Svyatogor I. A. , Mohovikova I. A.
Published: June 2020

The structure of statistical interaction of EEG wave components of persons with disturbing-phobia frustration was investigated in the course of adaptive biofeedback by brain potentials. The features of brain intercentral relations and their reorganisation were estimated in the process of correction of a psychophysiological condition by the biofeedback of brain potentials.
The cortical and extra-cortical bioelectrical processes determining the neurobiofeedback success and efficiency of sportsmen
Authors: Cherapkina L. P.
Published: June 2020

The changes of the functional condition of the 35 highly qualified sportsmen, neurodynamic and its changes of the frequency characteristic of the heart rate in the background recording during open and closed eyes before and after 15-days neurobiofeedback course is analyzed. It is discovered, that the functional left hemisphere asymmetry was typical for sportsmen having the quiet wakefulness condition according the power of all main rhythms of the EEG. It is defined, that the predictor of the training efficiency is the theta-rhythm power in the recording during open eyes. The VLF-wave and the HF-wave middle power of the heart rate frequency and probably the hormonal cycle of women body have the material effect to training success.
Role of stilbens in mechanisms hepatoprotective properties of polyphenols Maackia amurensis
Authors: Chuchalin V. S. , Ratkin A. V. , Ratkin Ye. V. , Frolov V. N. , Ivanov V. V. , Fedoreyev S. A. , Bulgakov V. P. , Zorcaltsev S. S.
Published: June 2020

For finding-out of a role monomer and dimer srilbens in realization hepatoprotective properties of polyphenols maakia amurensis activity of polyphenolic complexes from wood (Maksar), an extract of cellular culture maakia amurensis, and also monomer and dimer srilbens, allocated of a substance Maksar was investigated.

Therapeutic efficiency of researched objects was estimated on their influence on survival rate of animals, morphological and biochemical parameters of a liver and wheys of blood of rats with an experimental СCl4-hepatites. It was established, that hepatoprotective influence of Maksar and an extract of cellular culture maakia amurensis is caused by presence of the sums isoflavonoids in their structure. Monomer and dimer srilbens do not show therapeutic activity at an experimental toxic hepatites.
Use the product mares milk in rehabilitation of patients with ischemic heart disease
Authors: Gilmutdinova L. T. , Yanturina N. H. , Kudayarova R. R. , Kamaletdinov S. H. , Yamaletdinov K. S. , Ahmadullin R. V. , Gabdelhakova L. A.
Published: June 2020

Studied antioxidant and therapeutic efficacy of the product fermented mares milk — kumis in the complex sanatorium treatment of 134 patients with stable angina pectoris I, II functional class (FC). Made kumis derived from fermented mares milk, Lactobacterium bulgaricum and yeasts such as Torula.

Kumis contributed to the activation of antioxidant enzymes against inhibition of peroxidation processes of metabolism and lipid-lowering effect. The developed approach is an effective method of complex of regenerative therapy in patients with chronic coronary heart disease.
State of health and efficiency of rehabilitation of Tomsk people subjected to the action of radiation during the liquidation of technogenic accidents and disasters
Authors: Kapilevich L. V. , Vnushinskaya M. A.
Published: June 2020

The investigation of the state of health of Tomsk people subjected to the action of radiation during the liquidation of technogenic accidents and disasters has revealed the progressing worsening of the health. Some peculiarities of the morbidity, invalidization, and mortality have been noted. An important aspect of the health improvement is the development and realization of individual rehabilitation programs.
Peculiarities of people mortality in the Tomsk Region and main ways of its decrease
Authors: Kladov S. Yu. , Konobeyevskaya I. N. , Karpov R. S.
Published: June 2020

Peculiarities in the structure of mortality of people living in the Tomsk Region have been revealed, and main ways to decrease the mortality have been determined. In 2002 the death rate in the Tomsk Region was 14.3 per 1000 people, which is lower than the average Russian death rate (16.3). The analysis of death causes has shown that the most frequent causes are diseases of the blood system, while the second and third places are occupied by the death from neoplasm, as well as from accidents, poisoning, and traumas.

The health factor should become of the high priority in all spheres of human activity. Any measure should favor the formation of the healthy life style and everybody’s personal responsibility for the health. It is worth developing the interbranch demographic concept of the Tomsk Region as an integral part of the concept of the enhancement of life quality for people living in the Tomsk Region.