bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models
Authors: Rondon Aurélie , Ty Nancy , Bequignat Jean-Baptiste , Quintana Mercedes , Briat Arnaud , Witkowski Tiffany , Bouchon Bernadette , Boucheix Claude , Miot-Noirault Elisabeth , Pouget Jean-Pierre , Chezal Jean-Michel , Navarro-Teulon Isabelle , Moreau Emmanuel , Degoul Françoise
Published: October 2017

Bioorthogonal chemistry represents a challenging approach in pretargeted radioimmunotherapy (PRIT). We focus here on mAb modifications by grafting an increase amount of trans-cyclooctene (TCO) derivatives (0 to 30 equivalents with respect to mAb) bearing different polyethylene glycol (PEG) linkers between mAb and TCO (i.e. PEG0 (1), PEG4 (2) and PEG12 (3)) and assessing their functionality. We used colorectal xenograft (HT29/Ts29.2) and peritoneal carcinomatosis (A431-CEA-Luc/35A7) as tumor cells/mAbs models and fluorescent tetrazines (TZ). MALDI-TOF MS shows that grafting with 2,3 increases significantly the number of TCO per mAb compared with no PEG. In vitro immunofluorescence showed that Ts29.2 and 35A7 labeling intensity is correlated with the number of TCO when using 1,3 while signals reach a maximum at 10 equivalents when using 2. Under 10 equivalents conditions, the capacity of resulting mAbs-1–3 for antigen recognition is similar when reported per grafted TCO and comparable to mAbs without TCO. In vivo, on both models, pretargeting with mAbs-2,3 followed by TZ injection induced a fluorescent signal two times lower than with mAbs-1. These findings suggest that while PEG linkers allow a better accessibility for TCO grafting, it might decrease the number of reactive TCO. In conclusion, mAb-1 represents the best candidate for PRIT.
Anatomy of the external branch of the superior laryngeal nerve in Asian population
Authors: Cha Yong Hoon , Moon Seo-Young , Jehoon O. , Tansatit Tanvaa , Yang Hun-Mu
Published: October 2017

Injury to the external branch of the superior laryngeal nerve (eSLN) can cause a hoarse or weak voice with dysergia of the cricothyroid. The present study provided the topographic information of the eSLN in the Asian and verified anatomical validity of the landmarks previously recruited to localize the eSLN. Thirty specimens were dissected from 16 human embalmed cadavers (12 men and four women; mean age: 80.5 years). The vertical distance between the eSLN and the apical pole of the thyroid gland (AP) was 8.2 ± 4.2 mm. It descended over the AP with <1 cm distance in 51.7%, >1 cm distance in 27.6% and under the AP in 20.7%. The piercing point (PP) of the eSLN to the muscles located 26.0 ± 5.5 mm posterior and 14.7 ± 5.0 mm inferior to the laryngeal prominence. Generally, the PP located superoposterior to the midpoint of the joint between the joint of inferior constrictor and cricothyroid (ICJ). The distance between the PP and the midpoint was 8.7 ± 5.1 mm. We found that 1) the Asian had the eSLN located over the AP with <1 cm distance about half cases, 2) the PP can be a consistent reference for the eSLN identification, 3) the ICJ can be a useful landmark to preserve the eSLN at the PP.
Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis
Authors: Günther F. , Heidt T. , Kramer M. , Khanicheh E. , Klibanov A. L. , Geibel-Zehender A. , Ferrante E. A. , Hilgendorf I. , Wolf D. , Zirlik A. , Reinöhl J. , Bode C. , Peter K. , Kaufmann B. A. , Mühlen C. von zur
Published: October 2017

Platelets can be found on the surface of inflamed and ruptured atherosclerotic plaques. Thus, targeting of activated platelets may allow for molecular imaging of vulnerable atherosclerotic lesions. We here investigated microbubbles (MB) functionalized with the selectin ligand sialyl Lewisa individually (MBsLea) or dually with sLea and an antibody targeting ligand-induced binding sites of the activated GPIIb/IIIa receptor (MBDual). Assessed by in vitro flow chamber, targeted MB exhibited increased adhesion to platelets as compared to MBControl. While MBsLea rolled slowly on the platelets’ surface, MBDual enhanced the percentage of firm adhesion. In vivo, MB were investigated by ultrasound in a model of ferric chloride induced non-occlusive carotid artery thrombosis. MBsLea and MBDual revealed a higher ultrasound mean acoustic intensity than MBControl (p < 0.05), however MBDual demonstrated no additional increase in mean signal intensity as compared to MBsLea. The degree of carotid artery stenosis on histology correlated well with the ultrasound acoustic intensity of targeted MB (p < 0.05). While dual targeting of MB using fast binding carbohydrate polymers and specific antibodies is a promising strategy to support adhesion to activated platelets under arterial shear stress, these advantages seem not readily translatable to in vivo models.
Health-related quality of life among adults with and without hypertension: A population-based survey using EQ-5D in Shandong, China
Authors: Zhang Li , Guo Xiaolei , Zhang Jiyu , Chen Xi , Zhou Chengchao , Ge Dandan , Qian Yangyang
Published: October 2017

Previous studies have focused on health-related quality of life (HRQoL) in hypertensive individuals, but few studies have attempted to compare HRQoL between hypertensive and normotensive individuals using the EQ-5D in China. Based on a survey of 3509 adults aged 18 + years, we compared HRQoL between hypertensive and normotensive individuals using a chi-square test, t-test and multi-linear regression model. The results indicated that HRQoL in hypertensive individuals was poorer than that of normotensive individuals in all domains of the EQ-5D and its utility index. In addition, education, complications, household income, and family history of HBP were associated with HRQoL among the hypertensive patients. Factors including age, education, household income, health expenditure, place of residence, and family history of high blood pressure (HBP) were found to be associated with HRQoL in normotensive individuals. Interventions targeting at-risk subgroups, such as modifying existing health insurance schemes to improve them for poor individuals, might be helpful to improve HRQoL.
High prevalence of inadequate sitting and sleeping postures: a three-year prospective study of adolescents
Authors: Noll Matias , Candotti Cláudia Tarragô , da Rosa Bruna Nichele , do Valle Marja Bochehin , Antoniolli Arthur , Vieira Adriane , Loss Jefferson Fagundes
Published: October 2017

There is a paucity of information regarding the development of body posture during adolescence. This three-year prospective study aimed to evaluate sitting and sleeping postures among adolescents, and to determine whether these postures are associated with age and sex. We assessed 525 adolescents aged 11–16 years from the fifth to eighth grades. These adolescents were reassessed three years later. The Back Pain and Body Posture Evaluation Instrument was used to evaluate the sleeping posture and three sitting positions: sitting to write, to use a computer, and during leisure activities. Our findings indicated a low prevalence of adequate sleeping and sitting postures at baseline, with a decrease in prevalence observed after three years for all postures. These changes were similar for both sexes. Moreover, we found a strong reduction of adequate posture prevalence for younger adolescents, but the oldest adolescents demonstrated no significant differences after three years. Early, rather than late, adolescence is a critical period for establishing inadequate sitting and sleeping postures. This has implications for posture throughout adulthood; hence, interventions targeted at this age group are needed.
Carbon Adsorbents With Dual Porosity for Efficient Removal of Uremic Toxins and Cytokines from Human Plasma
Authors: Pavlenko D. , Giasafaki D. , Charalambopoulou G. , van Geffen E. , Gerritsen K. G. F. , Steriotis T. , Stamatialis D.
Published: October 2017

The number of patients with chronic kidney disease increases while the number of available donor organs stays at approximately the same level. Unavoidable accumulation of the uremic toxins and cytokines for these patients comes as the result of malfunctioning kidneys and their high levels in the blood result in high morbidity and mortality. Unfortunately, the existing methods, like hemodialysis and hemofiltration, provide only partial removal of uremic toxins and/or cytokines from patients’ blood. Consequently, there is an increasing need for the development of the extracorporeal treatments which will enable removal of broad spectrum of uremic toxins that are usually removed by healthy kidneys. Therefore, in this work we developed and tested ordered mesoporous carbons as new sorbents with dual porosity (micro/meso) that provide selective and efficient removal of a broad range of uremic toxins from human plasma. The new sorbents, CMK-3 are developed by nanocasting methods and have two distinct pore domains, i.e. micropores and mesopores, therefore show high adsorption capacity towards small water soluble toxins (creatinine), protein-bound molecules (indoxyl sulfate and hippuric acid), middle molecules (β-2-microglobulin) and cytokines of different size (IL-6 and IL-8). Our results show that small amounts of CMK-3 could provide selective and complete blood purification.
A compendium of geochemical information from the Saanich Inlet water column
Authors: Torres-Beltrán Mónica , Hawley Alyse K. , Capelle David , Zaikova Elena , Walsh David A. , Mueller Andreas , Scofield Melanie , Payne Chris , Pakhomova Larysa , Kheirandish Sam , Finke Jan , Bhatia Maya , Shevchuk Olena , Gies Esther A. , Fairley Diane , Michiels Céline , Suttle Curtis A. , Whitney Frank , Crowe Sean A. , Tortell Philippe D. , Hallam Steven J.
Published: October 2017

Extensive and expanding oxygen minimum zones (OMZs) exist at variable depths in coastal and open ocean waters. As oxygen levels decline, nutrients and energy are increasingly diverted away from higher trophic levels into microbial community metabolism, resulting in fixed nitrogen loss and production of climate active trace gases including nitrous oxide and methane. While ocean deoxygenation has been reported on a global scale, our understanding of OMZ biology and geochemistry is limited by a lack of time-resolved data sets. Here, we present a historical dataset of oxygen concentrations spanning fifty years and nine years of monthly geochemical time series observations in Saanich Inlet, a seasonally anoxic fjord on the coast of Vancouver Island, British Columbia, Canada that undergoes recurring changes in water column oxygenation status. This compendium provides a unique geochemical framework for evaluating long-term trends in biogeochemical cycling in OMZ waters.
Evaluation of sialic acid based on electrochemical cytosensor with 3D micro/nanostructured sensing interface
Authors: Ma Shangshang , Hu Sisheng , Wang Qi , Liu Yuhong , Zhao Guangyao , Zhang Qicheng , Mao Chun , Zhao Bo
Published: October 2017

A novel electrochemical cytosensor with three-dimensional (3D) micro/nanostructured sensing interface for accurate analysis of SA from cell surface.
MnFe2O4@nitrogen-doped reduced graphene oxide nanohybrid: an efficient bifunctional electrocatalyst for anodic hydrazine oxidation and cathodic oxygen reduction
Authors: Khilari Santimoy , Pradhan Debabrata
Published: October 2017

A bifunctional MnFe2O4/N-rGO composite synthesized hydrothermally in a single step is demonstrated for hydrazine oxidation and oxygen reduction.
Viable pathways for the oxidative addition of iodobenzene to palladium(0)-triphenylphosphine-carbonyl complexes: a theoretical study
Authors: Pálinkás Noémi , Kollár László , Kégl Tamás
Published: October 2017

In the presence of CO and triphenylphosphine a manifold of potentially active Pd(0) catalysts can emerge. Iodobenzene follows an oxidative addition pathwayviaPd(PPh3)(CO) and Pd(PPh3)2.
Progress in the understanding of the pathology of allergic asthma and the potential of fruit proanthocyanidins as modulators of airway inflammation
Authors: Coleman Sara L. , Shaw Odette M.
Published: October 2017

The potential of fruit proanthocyanidins to modulate airway inflammation through interactions with immune cells and the microbiome.
Amentoflavone improves cardiovascular dysfunction and metabolic abnormalities in high fructose and fat diet-fed rats
Authors: Qin Li , Zhao Ying , Zhang Bin , Li Yan
Published: October 2017

Metabolic syndrome (MS) is a leading cause of mortality and morbidity in Western countries.
Current knowledge of intestinal absorption of bioactive peptides
Authors: Shen Weilin , Matsui Toshiro
Published: October 2017

This review discusses the recent insights gathered onin vitroandin vivoabsorption of peptides across intestinal membranes, into blood circulation.
Mechanism of the formation of the RecA–ssDNA nucleoprotein filament structure: a coarse-grained approach
Authors: Mukherjee Goutam , Pal Arumay , Levy Yaakov
Published: October 2017

In prokaryotes, the RecA protein catalyzes the repair and strand exchange of double-stranded DNA.
Parametric amplification in MoS2 drum resonator
Authors: Prasad Parmeshwar , Arora Nishta , Naik A. K.
Published: October 2017

Parametric amplification in a MoS2 drum resonator and the effect of Duffing non-linearity on the parametric amplitude gain.
Confined naked gold nanoparticles in ionic liquid films
Authors: Calabria Luciane , Fernandes Jesum A. , Migowski Pedro , Bernardi Fabiano , Baptista Daniel L. , Leal Rafael , Grehl Thomas , Dupont Jairton
Published: October 2017

Surface-clean Au nanoparticles (NPs) confined in films of ionic liquids (ILs) can be easily fabricated by sputtering deposition.
Controllable formation of multi-layered SnO2@Fe2O3 sandwich cubes as a high-performance anode for Li-ion batteries
Authors: Zeng Yi , Luo Jingze , Wang Yanzhe , Qiao Liang , Zou Bo , Zheng Weitao
Published: October 2017

The design and controllable synthesis of hollow multi-layered “sandwich” nanostructures offer opportunities for metal oxides to buffer the volume expansion and aggregation due to coalescence into bulk structures, while realizing improved tap density and superior ion transport.
Correction: An efficient charge separation and photocurrent generation in the carbon dot–zinc oxide nanoparticle composite
Authors: Barman Monoj Kumar , Mitra Piyali , Bera Rajesh , Das Somnath , Pramanik Amitava , Patra Amitava
Published: October 2017

Correction for ‘An efficient charge separation and photocurrent generation in the carbon dot–zinc oxide nanoparticle composite’ by Monoj Kumar Barman et al., Nanoscale, 2017, 9, 6791–6799.
Recent advances in fluoride-free aryne generation from arene precursors
Authors: Idiris Fahima I. M. , Jones Christopher R.
Published: October 2017

Aryne chemistry has flourished in the past few decades. This review highlights new aryne precursors that operate under fluoride-free conditions as alternative methodologies to the popular fluoride-mediated ortho-silylaryl triflates.
Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10
Authors: Green Anthony P. , Hardy Simon , Lee Alan T. L. , Thomas Eric J.
Published: October 2017

The modified Julia reaction was used to assemble the (E)-16,17-double bond in the first total synthesis of a derivative of a 20-deoxybryostatin, namely 7-des-O-pivaloyl-7-O-benzylbryostatin 10.
A pH and redox dual responsive homopolypeptide: synthesis, characterization, and application in “smart” single-walled carbon nanotube dispersion
Authors: Xiao Jiang , Tan Junyan , Jiang Rujian , He Xiongliang , Xu Yanzhi , Ling Ying , Luan Shifang , Tang Haoyu
Published: October 2017

We present the synthesis and characterization of a pH and redox dual responsive homopolypeptide which can be used as a dual responsive stabilizer to control the aggregation of carbon nanotubes in water.
Polydimethylsiloxane quenchable vitrimers
Authors: Stukenbroeker Tyler , Wang Wendi , Winne Johan M. , Du Prez Filip E. , Nicolaÿ Renaud , Leibler Ludwik
Published: October 2017

Reprocessable and recyclable PDMS vitrimers can be transformed into “quenched” vitrimers that exhibit conventional elastomer properties.
Structure, absolute configuration, and variable-temperature1H-NMR study of (±)-versiorcinols A–C, three racemates of diorcinol monoethers from the sponge-associated fungus Aspergillus versicolor 16F-11
Authors: Gu Bin-Bin , Tang Jie , Wang Shu-Ping , Sun Fan , Yang Fan , Li Lei , Xu Ying , Lin Hou-Wen
Published: October 2017

Structure, absolute configuration, and variable-temperature1H-NMR study of three racemates of diorcinol monoethers, (±)-versiorcinols A–C.
The size controlled synthesis of Cu2S/P25 hetero junction solar-energy-materials and their applications in photocatalytic degradation of dyes
Authors: Huang Hongqin , Li Fang , Wang Huigang , Zheng Xuming
Published: October 2017

The Cu2S quantum size effects and coverage effects on absorption edge, Raman frequency and photo-induced catalytic performance were investigated.
The effect of size and concentration of nanoparticles on the glass transition temperature of polymer nanocomposites
Authors: Serenko Olga A. , Roldughin Vyacheslav I. , Askadskii Andrey А. , Serkova Elena S. , Strashnov Pavel V. , Shifrina Zinaida B.
Published: October 2017

Here we use model nanocomposites based on polystyrene and polyphenylene dendrimers to show both theoretically and experimentally that inclusion of rigid nanoparticles of 2.3–5 nm size into the polymer leads to a negligible glass transition temperature (Tg) increase.
A two-step model for the tunneling conductivity of polymer carbon nanotube nanocomposites assuming the conduction of interphase regions
Authors: Razavi Razieh , Zare Yasser , Rhee Kyong Yop
Published: October 2017

This work develops a two-step model for the conductivity of polymer carbon nanotube (CNT) nanocomposites (PCNT) assuming the properties of tunneling and interphase regions.
Cobalt sulfide supported on nitrogen and sulfur dual-doped reduced graphene oxide for highly active oxygen reduction reaction
Authors: Zhang Ying , Li Pingwei , Yin Xuying , Yan Ya , Zhan Ke , Yang Junhe , Zhao Bin
Published: October 2017

An efficient composite catalyst of Co–S/NS-rGO has been successfully prepared by a facile one-step annealing approach, which demonstrates excellent catalytic activity and good durability in alkaline solution.
Osteocytes regulate osteoblast differentiation and osteoclast activity through Interleukin-6 under mechanical loading
Authors: Hao Zhichao , Ma Yuanyuan , Wu Jun , Li Xianxian , Chen Helin , Shen Jiefei , Wang Hang
Published: October 2017

Osteocytes are the major mechanosensors that respond to mechanical strain and regulate bone formation and resorption.
Diethylenetriamine-assisted in situ synthesis of TiO2 nanoparticles on carbon nanotubes with well-defined structure and enhanced photocatalytic performance
Authors: Peng Hailong , Yang Xiaoyan , Zhang Peng , Zhang Yiming , Liu Chengwei , Liu Dan , Gui Jianzhou
Published: October 2017

In solvothermal conditions, DETA will work as a connecting bridge to in situ form TiO2/CNT composites with a well-defined structure and enhanced photocatalytic performance.
Simple method for simultaneously achieving red and green up-conversion luminescence
Authors: Yin Xiumei , Wang Hong , Xing Mingming , Fu Yao , Tian Ying , Luo Xixian
Published: October 2017

The simultaneous emission of red and green light with high brightness and color purity was obtained from Er3+-doped NaYbF4-based up-conversion nanoparticles excited by 980 and 1550 nm.
Fluorescent binary ensemble with pattern recognition ability for identifying multiple metalloproteins with applications in serum and urine
Authors: Zheng Demin , Fan Junmei , Huang Xinyan , Ding Liping , Xin Yunhong
Published: October 2017

A fluorescent binary ensemble with multiple-wavelength cross-reactivity functioning as a discriminative sensor to identify different metalloproteins in serum or urine solution.
Near-infrared optical performances of two Bi2Se3nanosheets
Authors: Xie Hanhan , Shao Jundong , Wang Jiahong , Sun Zhengbo , Yu Xue-Feng , Wang Qu-Quan
Published: October 2017

Two Bi2Se3nanosheets have been successfully synthesized and exhibit excellent optical performances, and the smaller size one performs better.
Intuitionistic study on the critical decomposition energy of ammonium perchlorate by SEM
Authors: Liu Jie , Ke Xiang , Hao Ga-zi , Xiao Lei , Jiang Wei , Li Feng-sheng
Published: October 2017

Critical decomposition energy of ammonium perchlorate based on SEM images.
Microwave-assisted one-pot synthesis in water of carbonylpyrazolo[3,4-b]pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety
Authors: Polo Efrain , Ferrer-Pertuz Karoll , Trilleras Jorge , Quiroga Jairo , Gutiérrez Margarita
Published: October 2017

Pyrazolo[3,4-b]pyridines derivatives have been synthesized via one-pot condensation of 3-methyl-1-phenyl-1H-pyrazolo-5-amine (1), paraformaldehyde (2) and β-diketones (3) under microwave irradiation in aqueous media catalyzed by InCl3.
A novel metal-free two-dimensional material for photocatalytic water splitting – phosphorus nitride (γ-PN)
Authors: Tan Xiaohong , Ji Yujin , Dong Huilong , Liu Meiyi , Hou Tingjun , Li Youyong
Published: October 2017

Two-dimensional phosphorus nitride (γ-PN) is designed to be a potential photocatalyst for water splitting.
Co3O4 nanoparticles/MWCNTs composites: a potential scaffold for hydrazine and glucose electrochemical detection
Authors: Zhou Tuantuan , Gao Wanlin , Gao Yanshan , Wang Qiang , Umar Ahmad
Published: October 2017

We report the successful formation of cobalt oxide (Co3O4) nanoparticles/multi-walled carbon nanotubes (Co3O4/MWCNTs) composites as efficient electrocatalytic materials for chemical sensing.
Synthesis of tetrazole fused azepanes and quantum chemical topology study on the mechanism of the intramolecular cycloaddition reaction
Authors: Pino-Gonzalez M. S. , Romero-Carrasco A. , Calvo-Losada S. , Oña-Bernal N. , Quirante J. J. , Sarabia F.
Published: October 2017

Syntheses of novel tetrazolo azepanes by intramolecular 1,3-dipolar cycloaddition are described. Cyclization mechanistic topology study showed a pseudo concerted mechanism.
H2O2-responsive and plaque-penetrating nanoplatform for mTOR gene silencing with robust anti-atherosclerosis efficacy
Authors: Gao Wen , Zhao Yujie , Li Xiang , Sun Yuhui , Cai Michelle , Cao Wenhua , Liu Zhenhua , Tong Lili , Cui Guanwei , Tang Bo
Published: October 2017

A H2O2-responsive and plaque-penetrating S2P–CeO2–ASOs nanoplatform was developed for the effective silencing of mTOR and treatment of atherosclerosis.
Engineered Janus probes modulate nucleic acid amplification to expand the dynamic range for direct detection of viral genomes in one microliter crude serum samples
Authors: Zhao Yue , Chen Feng , Qin Jing , Wei Jing , Wu Wenhua , Zhao Yongxi
Published: October 2017

Janus probes were designed to expand the dynamic range of amplification for viral genome quantification in 1 μL crude serum.
FAD roles in glucose catalytic oxidation studied by multiphase flow of extractive electrospray ionization (MF-EESI) mass spectrometry
Authors: Wang Yan , Sun Min , Qiao Jinping , Ouyang Jin , Na Na
Published: October 2017

The role of the coenzyme flavin adenine dinucleotide (FAD) in the catalytic oxidation of glucose was elucidated by MS using a new extraction and ionization method.
A thermo-responsive supramolecular gel and its luminescence enhancement induced by rare earth Y3+
Authors: Ma Xinxian , Cui Yaqin , Liu Shiwei , Wu Jincai
Published: October 2017

A new thermal-responsive supramolecular organogel based on a dual benzimidazole type gelator was prepared. When RE (rare earth) Y3+ is employed and implanted in this gel above, it can be assembled into an enhanced blue-light-emitting supramolecular RE metallogel (Y@gel) in DMF–water mixtures.
Hydrogen bond directed surface dynamics at tactic poly(methyl methacrylate)/water interface
Authors: Jha Kshitij C. , Bekele Selemon , Dhinojwala Ali , Tsige Mesfin
Published: October 2017

Effect of PMMA tacticity on hydrogen bonding through subtle variance in carbonyl group participation and mobility has been elucidated.
Efficient PbS quantum dot solar cells employing a conventional structure
Authors: Lu Kunyuan , Wang Yongjie , Yuan Jianyu , Cui Zequn , Shi Guozheng , Shi Shaohua , Han Lu , Chen Si , Zhang Yannan , Ling Xufeng , Liu Zeke , Chi Lifeng , Fan Jian , Ma Wanli
Published: October 2017

New-generation solar cells based on colloidal lead chalcogenide (PbX) quantum dots (CQDs) are promising low-cost solution-processed photovoltaics.
Fermi level alignment by copper doping for efficient ITO/perovskite junction solar cells
Authors: Lu Kai , Lei Yan , Qi Ruijuan , Liu Jiang , Yang Xiaogang , Jia Zuxiao , Liu Rui , Xiang Yong , Zheng Zhi
Published: October 2017

The Fermi level of perovskite materials can be adjusted by Cu doping to facilitate charge collection at an ITO substrate without HTL.
Design of new photovoltaic systems based on two-dimensional group-IV monochalcogenides for high performance solar cells
Authors: Zhao Pei , Yang Hongchao , Li Jianwei , Jin Hao , Wei Wei , Yu Lin , Huang Baibiao , Dai Ying
Published: October 2017

A new photovoltaic system based on single layer group-IV monochalcogenides MX (M = Ge, Sn; X = S, Se) exhibits high performance.
Improved stability and efficiency of perovskite solar cells with submicron flexible barrier films deposited in air
Authors: Rolston Nicholas , Printz Adam D. , Hilt Florian , Hovish Michael Q. , Brüning Karsten , Tassone Christopher J. , Dauskardt Reinhold H.
Published: October 2017

We report on submicron organosilicate barrier films produced rapidly in air by a scalable spray plasma process that improves both the stability and efficiency of perovskite solar cells.
Self-assembled RGD dehydropeptide hydrogels for drug delivery applications
Authors: Vilaça Helena , Castro Tarsila , Costa Fernando M. G. , Melle-Franco Manuel , Hilliou Loic , Hamley Ian W. , Castanheira Elisabete M. S. , Martins José A. , Ferreira Paula M. T.
Published: October 2017

Combining a minimalist naproxen N-capped dehydrodipeptide hydrogelator block with a peptide bioepitope, illustrated in this work by the Npx-l-Ala-Z-ΔPhe-G-R-G-D-G-OH construct, is an efficient approach to produce functional hydrogels.
Communication between hydrogel beadsviachemical signalling
Authors: Jaggers Ross W. , Bon Stefan A. F.
Published: October 2017

In this work, we demonstrate chemical communication between millimetre-sized soft hydrogel beads in an aqueous environment.
Quenched hexacene optoacoustic nanoparticles
Authors: Nunes Antonio , Pansare Vikram J. , Beziere Nicolas , Ntoukas Argiris Kolokithas , Reber Josefine , Bruzek Matthew , Anthony John , Prud’homme Robert K. , Ntziachristos Vasilis
Published: October 2017

Flash NanoPrecipitation allows for the creation of optoacoustic imaging agents with tunable size and strong signal for biomedical imaging and therapy.
A simple and dopant-free hole-transporting material based on (2-ethylhexyl)-9H-carbazole for efficient planar perovskite solar cells
Authors: Zhang J. , Xu L. J. , Huang P. , Zhou Y. , Zhu Y. Y. , Yuan N. Y. , Ding J. N. , Zhang Z. G. , Li Y. F.
Published: October 2017

Planar perovskite solar cells based on CMO as the HTM showed a high power conversion efficiency of 15.92%.
Anisotropic electrical conductivity in polymer derived ceramics induced by graphene aerogels
Authors: Shen Chen , Calderon Jean E. , Barrios Elizabeth , Soliman Mikhael , Khater Ali , Jeyaranjan Aadithya , Tetard Laurene , Gordon Ali , Seal Sudipta , Zhai Lei
Published: October 2017

Anisotropic electrical conductivity was introduced into bulk polymer derived ceramics by embedded reduced graphene oxide aerogels.
Cu-Doped nickel oxide prepared using a low-temperature combustion method as a hole-injection layer for high-performance OLEDs
Authors: Li Yi-Huan , Lu Xun , Wang Rongbin , Ma Yu-Yang , Duhm Steffen , Fung Man-Keung
Published: October 2017

Low-temperature combustion methods to deposit s-NiOx and s-Cu-NiOx on ITO glass to fabricate efficient green phosphorescent OLEDs.
Strong contribution ofin situgrown nanowires to enhance the thermostabilities and microwave absorption properties of porous graphene foams under different atmospheres
Authors: Dong Shun , Song Juntao , Zhang Xinghong , Hu Ping , Sun Boqian , Zhou Shitong , Luo Xiaoguang
Published: October 2017

Enhanced thermostabilities and microwave absorption properties of porous graphene foams modified within situgrown nanowires under different atmospheres.
Towards efficient microwave absorption: intrinsic heterostructure of fluorinated SWCNTs
Authors: Zhang Yichun , Liu Yang , Wang Xu , Yuan Yuehui , Lai Wenchuan , Wang Zaoming , Zhang Xiaojiao , Liu Xiangyang
Published: October 2017

Intrinsic heterostructure in inhomogeneous fluorinated SWCNT promotes their microwave absorption efficiency.
Themed issue on 2D materials
Authors: Chhowalla Manish , Lin Zhong , Terrones Mauricio
Published: October 2017

Guest editors Manish Chhowalla, Zhong Lin and Mauricio Terrones introduce this Journal of Materials Chemistry C themed issue on 2D materials.
TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis
Authors: Owen David R. , Fan Jinjiang , Campioli Enrico , Venugopal Sathvika , Midzak Andrew , Daly Edward , Harlay Aline , Issop Leeyah , Libri Vincenzo , Kalogiannopoulou Dimitra , Oliver Eduardo , Gallego-Colon Enrique , Colasanti Alessandro , Huson Les , Rabiner Eugenii A. , Suppiah Puvan , Essagian Charles , Matthews Paul M. , Papadopoulos Vassilios
Published: October 2017

The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial membrane protein implicated in numerous cell and tissue functions, including steroid hormone biosynthesis, respiration, cell proliferation, and apoptosis. TSPO binds with high affinity to cholesterol and numerous compounds, is expressed at high levels in steroid-synthesizing tissues, and mediates cholesterol import into mitochondria, which is the rate-limiting step in steroid formation. In humans, the rs6971 polymorphism on the TSPO gene leads to an amino acid substitution in the fifth transmembrane loop of the protein, which is where the cholesterol-binding domain of TSPO is located, and this polymorphism has been associated with anxiety-related disorders. However, recent knockout mouse models have provided inconsistent conclusions of whether TSPO is directly involved in steroid synthesis. In this report, we show that TSPO deletion mutations in rat and its corresponding rs6971 polymorphism in humans alter adrenocorticotropic hormone-induced plasma corticosteroid concentrations. Rat tissues examined show increased cholesteryl ester accumulation, and neurosteroid formation was undetectable in homozygous rats. These results also support a role for TSPO ligands in diseases with steroid-dependent stress and anxiety elements.
A network meta-analysis of short-term efficacy of different single-drug targeted therapies in the treatment of renal cell carcinoma
Authors: He Hong-Ling , Yao Wan-Xia
Published: October 2017

The network meta-analysis was conducted to compare the short-term efficacy of different single-drug targeted therapies in the treatment of renal cell carcinoma (RCC). We initially searched databases for randomized controlled trials (RCTs) on different single-drug targeted therapies in treating RCC. The meta-analysis combined the direct and indirect evidence to calculate the pooled odds ratios (OR) and draw surface under the cumulative ranking curves (SUCRA). A total of 14 eligible RCTs were ultimately selected. The partial response (PR) of Cabozantinib in the treatment of RCC was better than Sunitinib (OR = 2.7, 95%CI = 1.0–7.8), Everolimus (OR = 8.1, 95%CI = 3.1–25.0), and Temsirolimus (OR = 4.8, 95%CI = 1.0–31.0); the overall response rate (ORR) of Cabozantinib was better than Sorafenib, Sunitinib, Everolimus, and Temsirolimus (OR = 5.5, 95%CI = 1.1–27.0; OR = 2.6, 95%CI = 1.1–6.6; OR = 8.3, 95%CI = 3.5–20.0; OR = 5.7, 95%CI = 1.3–28.0 respectively). In addition, as for complete response (CR), PR, stable disease (SD), progressive disease (PD), ORR, and disease control rate (DCR), Cabozantinib had the best short-term efficacy among nine single-drug targeted therapies in the treatment of RCC (CR: 50.3%; PR: 93.6%; SD: 75.1%; PD: 68.0%; ORR: 95.5%; DCR: 73.2%); while Everolimus had the worst short-term efficacy (CR: 33.6%; PR: 22.3%; SD: 78.0%; PD: 35.9%; ORR: 22.9%; DCR: 19.9%). Our network meta-analysis indicated that Cabozantinib might have better short-term efficacy than other regimens in the treatment of RCC, while Everolimus might have poor short-term efficacy.
Dual Task, Noise, and The Speech-Language Pathologist: A Clinical Guideline for Adult Multi-Tasking Intervention With Noise
Authors: Harvey Jennine , Seeman Scott , von Hapsburg Deborah
Published: October 2017

The field of Cognitive Hearing Science examines the relationship between cognitive, linguistic, and hearing functions. Although these areas are of particular importance to speech-language pathology, few studies have investigated applications of cognitive hearing science to clinical practice. The purpose of this review article is to (1) explore and present a summary of cognitive hearing science techniques for dual-task and hearing-in-noise procedures and implications to speech-language pathology, and (2) provide a clinical guide for speech-language pathology in adult multitasking intervention with noise. It is well understood that areas of cognitive skill and hearing function decline with age; therefore, additional understanding of the relationship of these functions is of particular importance to speech-language pathologists working with older individuals. This article meets the American Speech-Language-Hearing Association's (ASHA's) Special Interest Group (SIG) 15's mission of “research-to-practice” professional development by “promoting understanding of the effects of normal and pathological aging on cognition, language […] and hearing” (ASHA, 2017), and is intended to be of interest to the SIG 15 readership.
Hybrid waveguide/coaxial feeder for dual‐pol Fabry‐Perot cavity antennas radiating omnidirectional TM/TE waves
Authors: Comite D. , De Santis P. , Burghignoli P. , Baccarelli P. , Galli A.
Published: October 2017

A hybrid waveguide/coaxial transverse magnetic (TM)/transverse electric (TE) launcher is proposed as a feeder for planar Fabry‐Perot (FP) cavity antennas radiating omnidirectional beams. The structure is based on a pair of nested coaxial cables. The inner coax (TM launcher) operates on the standard TEM mode and feeds a vertical probe protruding into the antenna cavity through the ground plane. The outer coax (TE launcher) operates on the TE01 mode excited by an aperture‐coupled rectangular‐waveguide feeding network. Geometrical symmetry ensures high isolation between the TM and TE input ports, which can be alternatively excited to achieve dual‐pol operation with either horizontal or vertical linearly‐polarised far field. Good impedance matching and omnidirectional dual‐pol radiative features are demonstrated for an FP cavity antenna operating at 16 GHz and based on a thin periodic metal partially‐reflecting surface.
Quasi‐lumped dual‐mode reconfigurable eight‐way FPD
Authors: Zhu Chuanming , Kang Wei , Wu Wen
Published: October 2017

A quasi‐lumped dual‐mode reconfigurable eight‐way filtering power divider (FPD) is presented. Two operating modes are one eight‐way tunable FPD and one all stopband filter (ASF) with high suppression. The measured eight‐way FPD can be tuned from 1.0 to 2.15 GHz, corresponding to the frequency tuning range (FTR) of 73%. The ASF is obtained by misaligning resonant frequencies of LC resonators and weakening their coupling. The proposed dual‐mode FPD has the advantage of wide FTR, compact size, high isolation, ultra‐wide isolation BW, and high suppression.
Transfer printing of semiconductor nanowire lasers
Authors: Hurtado Antonio , Jevtics Dimitars , Guilhabert Benoit , Gao Qian , Tan Hark Hoe , Jagadish Chennupati , Dawson Martin D.
Published: October 2017

The authors review their work on the accurate positioning of semiconductor nanowire (NW) lasers by means of nanoscale Transfer Printing (nano‐TP). Using this hybrid nanofabrication technique, indium phosphide NWs are successfully integrated at selected locations onto heterogeneous surfaces with high positioning accuracy. Moreover, they show that NW lasers can also be organised to form bespoke spatial patterns, including (one‐dimensional) 1D or 2D arrays, or complex configurations with a defined number of NWs and controlled separation between them. Besides, their nano‐TP technique also permits the integration of NWs with different dimensions in a single system. Notably, the nano‐TP fabrication protocols do not affect the optical or structural properties of the NWs and they retain their room‐temperature lasing emission after their positioning onto all investigated receiving surfaces. This developed nano‐TP technique offers therefore new exciting prospects for the fabrication of hybrid bespoke nanophotonic systems using NW lasers as building blocks.
Bimetallic Ag–Ru/γ‐Al2O3 nanoparticles for selective hydrogenation of cinnamaldehyde to hydrocinnamaldehyde
Authors: Li Rongrong , Chen Hong , Gan Zhixing , Jiang Ming , Zhong Aiguo , Bao Huanhuan
Published: October 2017

This work reports an efficient co‐catalyst of AgRu nanoparticles supported on γ‐Al2O3 for highly selective hydrogenation of the C=C bond of cinnamaldehyde (CAL) at 443 K, uncovering a catalytic route for selective hydrocinnamaldehyde production from the CAL. This kind of chemo‐selectivity of AgRu/γ‐Al2O3 catalyst seems unique since any competitive hydrogenation at the conjugated C=O bond was significant.
Performance enhancement of a renewable thermal energy collector using metallic oxide nanofluids
Authors: Sekhar Talluri Venkata Raja , Prakash Ravi , Nandan Gopal , Muthuraman Marisamy
Published: October 2017

A renewable thermal energy collection device was built and metallic oxide nanofluids namely cerium oxide, aluminium oxide and titanium oxide in base fluid water were used. At 3 vol% and a flow of four litres per minute, the renewable energy collector efficiency was computed and compared with the values obtained using water as the working fluid. It was observed that by using Ceria, Alumina and Titania nanofluids, collector efficiencies of 60%, 58% and 56% were achieved respectively. When compared with the values obtained by using water, the efficiency enhancement was 27% for Ceria, 25% for Alumina and 23% for Titania nanofluids.
Mechanisms Involved in Premature Aging in the Heart—Is There an Implication for Cardiac Surgery?
Authors: Simm Andreas , Rohrbach Susanne , Niemann Bernd
Published: October 2017

During the past century, life expectancy has risen in Germany from 35.6 and 38.5 years in men and women (1871/1881) to 78.2 and 83.1 years (2013/2015). In recent years, the dominance of chronic diseases as major contributors to total global mortality has emerged. The incidence of cardiovascular diseases (CVD) increases in westernized societies and projected trends suggest that by 2030, CVD alone will also be responsible for more deaths in low-income countries than infectious diseases. The occurrence of CVD also seems to correlate to a further increase of biological age within westernized societies. Therefore, age-associated changes in the heart are an issue of high interest in cardiac surgery. The chronological age is a prognostic marker in some clinical scoring systems. However, it does not represent an adequate estimation of the biological age of patients or their perioperative risk. In fact, frailty might be a more powerful predictor for normal perioperative course or risk escalation. An unhealthy, sedentary lifestyle can induce premature aging of vessels and myocardium. Understanding the age-associated genetic, biochemical, and pathophysiological changes can help identify the therapeutic capability of aged myocardium. Future “therapeutic myocardial rejuvenation” may represent a powerful tool for the stabilization of the perioperative course in aged patients. In this review, we will focus on selected mediators or conditions with impact on age-associated myocardial changes with a major focus on obesity and discuss potential therapeutic strategies to utilize or modify these mediators.
Pseudoaneurysm following Endoscopic-Assisted Repair of Subcondylar Fracture
Authors: Ambrose Emily , Sokoya Mofiyinfolu , Eustaquio Marcia
Published: October 2017

Pseudoaneurysms are a known complication following facial trauma and orthognathic surgery. Few reports exist of this clinical entity following traditional open techniques of repair, and none have been associated with endoscopic-assisted open reduction and internal fixation (ORIF) of a subcondylar fracture. We present a case of a 33-year-old man who developed pseudoaneurysm after endoscopic-assisted ORIF as well as a review of the literature on this topic. While uncommon, this is a potential complication that should be recognized with the use of endoscopic-assisted repair of mandibular fractures.
Traumatic Anterosuperior Dislocation of the Intact Mandibular Condyle into the Temporal Fossa
Authors: Silveira Roger Lanes , Ranuzia Ivan , Melo Marcelo Fernandes S. , de Oliveira RogerioAraujo , de Brito Antonio Alburquerque , Vidigal Victor Laviola
Published: October 2017

Temporomandibular joint (TMJ) dislocation, or luxation, occurs when the condyle crosses the articular eminence in such a way that it does not return to its correct anatomical position, unless aided by a reduction in external forces for TMJ. The diagnosis of condylar luxation is clinical; however, image exams are important in classifying the types of condylar luxation and associated fractures. Displacement of the TMJ can occur due to either an exaggerated mouth opening or a forced opening and occasionally is associated with a high-impact trauma to the jaw, the latter being an extremely rare condition. Few cases of anterosuperior dislocation of the intact mandibular condyles into the temporal fossa (ADIMC) have been documented in medical literature, many of which are associated with craniofacial trauma. This study describes the case of an ADIMC of the left side combined with facial fractures, as well as the treatment performed. A review of cases found in the literature from 1969 to 2017 was conducted through a detailed bibliographical study.
Interprofessional Education and Practice: A Family-Centered Approach to Autism
Authors: Potvin Marie-Christine , Savard Liliane , Prelock Patricia
Published: October 2017

The article discusses the role of interprofessional education (IPE) and interprofessional collaborative practice (IPCP) in the delivery of service to a young child with autism spectrum disorder (ASD) and his family. An introduction to the concepts is provided with an outline of the strengths and challenges evident in implementing an IPCP approach to quality care. The core competencies for IPE and IPCP are also explained with examples of their application to children with ASD and their families. After reading this article, health care providers should be able to summarize their role in IPE and IPCP and identify their responsibility as a member of a collaborative team. The value of an interprofessional team in practice is emphasized, and ways to build successful teams are explained.
Effect of Preoperative Medical Status on Microsurgical Free Flap Reconstructions: A Matched Cohort Analysis of 969 Cases
Authors: Heidekrueger Paul , Ninkovic Milomir , Broer P. , Ehrl Denis
Published: October 2017

Background Free tissue transfers have become standard for a wide variety of reconstructive purposes. In an era of increasing economic pressure, it is important to precisely define appropriate candidates and indications for a complex surgery to optimize efficiency and patient outcomes. This study evaluates the feasibility to perform microsurgical procedures in a medically compromised patient cohort at a major academic microsurgical center.

Methods Within 7 years, 897 patients underwent 969 microvascular free flap reconstructions. The data were retrospectively screened for patients' demographics, perioperative details, flap survival, surgical complications, and outcomes. The cases were divided into two groups in “low-risk” (American Society of Anesthesiologists [ASA] I and II) or “high-risk” (ASA III and IV) as per the preoperative medical status classified according to the ASA score of physical status.

Results Despite the significantly high prevalence of hypertension, peripheral artery disease, diabetes, obesity, and smoking status in the “high-risk” group (p < 0.05), there was no significant difference in the rate of surgical or medical complications, in operative times regarding overall as well as different flap entities, flap failures, need for revision surgery, or hospital length of stay between the two patient groups during our 3-months follow-up period (p > 0.05).

Conclusion In this study, free flap reconstruction in medically compromised patients was not associated with higher rates of revision surgeries, overall complication rates, or surgery-related costs. Complex microsurgical free flap reconstruction can therefore also be advocated in patients with high preoperative risk constellation.
Microsurgery Fellowships—Development of a Clinical Curriculum
Authors: Lam Wee-Leon , Rostom Mai
Published: October 2017

Background Microsurgery fellowships have become an integral part of every plastic surgery training program. While each subspecialty differs in terms of reconstructive requirements, the basic tenets and skill sets remain the same. We explore the possibility of designing a clinical curriculum for microsurgery that can provide residents and fellows with a more foundational and structured approach to microsurgical training.

Methods Thirteen core and desired skills to accommodate an “ideal” microsurgery curriculum were listed and categorized according to the level of difficulty. The curriculum was then sent to plastic surgery trainees, fellows, and consultants within Scotland in the form of a survey. They were asked to assign a level of difficulty, basic, intermediate, or advanced, to each of the 13 skill sets.

Results A total of 27 surgeons were surveyed; the majority of which were plastic surgery registrars. Overall a broad, generic clinical curriculum was felt to be lacking, but would be beneficial at the start of training. The curriculum should emphasize a step-wise progression, starting from achieving competency in safe, efficient anastomosis at the basic level to eventually mastering the principles of complex reconstruction at a more advanced level.

Conclusions A generic clinical curriculum offers a framework for tracking progress, the potential for competency-based assessment, and aid in designing a microsurgery fellowship. The curriculum should reflect the evolving nature of the specialty and provide a foundational platform for future innovations.
Resternotomy Plus Left Thoracotomy Surgery after Previous Acute Type A Aortic Dissection Repair
Authors: Yoshida Takeshi , Kakii Bunpachi , Furui Masato , Uchino Gaku
Published: October 2017

Background As the results of acute type A aortic dissection repair have improved, late reoperation for residual dissection has become increasingly important. We report our experience of graft replacement via extended approaches after a previous acute type A aortic dissection repair.

Methods From April 2003 to September 2016, 17 patients underwent reoperation via extended (repeat median sternotomy plus left thoracotomy) approaches after a previous repair of an acute type A aortic dissection at the Matsubara Tokushukai Hospital in Japan and were included in the analyses (males, 16; mean age at surgery, 60.0 ± 9.3 years).

Results The postoperative stroke and in-hospital mortality rates were 0 and 5.9%, respectively.

Conclusion Extended approach after a previous acute type A aortic dissection repair showed acceptable outcomes.