bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance of Human Resource Management in 21st Century: A Theoretical Perspective
Authors: Aslam Hassan Danial , Aslam Mehmood , Ali Naeem , Habib Badar
Published: February 2017

Human Resource Management discipline extracted its roots from organizational psychology discipline and proved to be an important practice for managing organizations. The role of this practice has emerged to be strategic with passage to time. Today the role of human resource management departments has become inevitable for 21st century modern businesses. This article focuses upon role of human resource management practice in 21st century. This theoretical paper is aiming the importance of human resource managers, HR practices and its influencing factors. In addition to that, this article also elaborates the upcoming challenges which are faced by 21st century HR managers. Author has conducted HR literature analysis in order to present emerging issues, challenges and practices of human resource management discipline in context of 21st century.
Implementation of Standard Specifications on Secondary School Facilities in Etsako West Local Government Area, Edo State
Authors: Charity Ugiomoh, Isoa , Nwuju Ememe, Ogbonna , Nnennaya Obike, Comfort
Published: February 2017

This study investigated the extent of the implementation of standard specifications on secondary schools facilities in Etsako West Local Government Area, Edo State. It was a descriptive survey. A sample of 135 teachers emerged from a population of 432 through stratified random representation. A 2-part, 18-item, 4-point scale instrument known as standard specification questionnaire (SSQ) was used to collect data for answering 2 research questions. SSQ was validated by a team of experts. Test-retest reliability was established at an r-0.85. Findings revealed among others that lack of funds posed a major problem in the implementation of standard specification on secondary schools’ facilities on public/rural schools. It was concluded that if education is well funded, enough specified facilities provided, it will go a long way in breeding intellectuals who are morally, culturally, socially, and intellectually balanced to give society the necessary level of economic development. It was recommended among others that classrooms must be spacious enough to promote adequate interdisciplinary learning.
International HR Assignment in Recruiting and Selecting: Challenges, Failures and Best Practices
Authors: Thoo Lily , Kaliannan Maniam
Published: February 2017

This study attempts to examine various issues pertaining to the complexities of international assignment, one of the major dimensions of International Human Resource Management (IHRM). It is our hope that by deep understanding of the uniqueness of international staffing policies, root causes of expatriate failure as well as the challenges encountered by expatriates; a more strategic IHRM approach can then be strategized by multinational corporations (MNCs) taking into consideration of some personalized best practices in effort to avoid or reduce the chances of international assignment failures in future.
Employee’s Emotions: A Manageable Weapon for Organizations
Authors: Boateng Irene Akuamoah , Agyei Albert
Published: February 2017

Emotion in the workplace for many years was only considered important in relation to employee wellbeing and job satisfaction. In recent times, it has been recognized that emotions play a role in almost all work activities. Consequently, this research is to determine the relevance of managing employees emotions at the workplace. The study dealt with the identification of the causes of employee emotions, challenges faced by managers in regard to the management of employee’s emotions and examined the measures used in managing employee emotions. Primary data was collected by administering questionnaire to employees and management of Valley View University. Sample size of fifty (50) employees and ten (10) management members were selected conveniently for the study. The study revealed that the main causes of employee emotion are, excessive workload, lack of guidance and support, meeting deadlines, role dissatisfaction and ambiguity of job description. Measures identified that are used in managing employee emotions are provision of counseling centre, organization of periodic seminars on how to deal with emotions and other work related issues, creation of harmonious relationship with employees and reduced work load. The challenges faced by managers with regard to the management of employee’s emotions are miscommunication and inability of the employer in identifying the personal traits of the employee.
"Cross Media": Konsequenzen für den Journalismus
Authors: Meier Klaus
Published: February 2017

Die Geschwindigkeit des Journalismuswandels ist enorm gestiegen. Dabei entwickelt sich das Internet zu einer zentralen Drehscheibe für Text, Bild, Video und Audio und wird zu einer ernsthaften Konkurrenz für die traditionellen Plattformen der Massenmedien. Das hat tief greifende Konsequenzen für den Journalismus. Dieser Beitrag analysiert zentrale Trends zum Thema "Cross Media", wobei mit dem "Kreuzen der Medien" vor allem die Schnittstellen zwischen einerseits den traditionellen Medien Print und Rundfunk gemeint sind, andererseits die neuen digitalen Plattformen. Dabei stehen im Mittelpunkt die Fragen nach dem "Warum?" es zu den gegenwärtigen "Cross Media"-Strategien gekommen ist und nach dem "Wie?" der Umsetzungen in journalistischen Redaktionen.
Gingival Enlargement as a Manifestation of Osseous Choristoma
Authors: Rosa Roberta Rezende , Paulo Luiz Fernando Barbosa de , Oliveira Júnior Anísio Domingos de , Durighetto Junior Antonio Francisco
Published: February 2017

The term choristoma describes a hamartomatous tumor-like lesion composed of normal tissue in an abnormal location and are designated according to the tissues from which they are derived. Typically, osseous choristomas of the oral cavity present as slow growing masses in the tongue, and rare cases are reported in the buccal mucosa and in the alveolar ridge. To our knowledge, few cases of gingival osseous choristoma have been reported, and the clinical differential diagnoses are very important for the practitioners. This report presents a rare location of a choristoma which by the clinical appearance and microscopic findings was shown to be an osseous choristoma presented in alveolar mucosa.
Pigmented lesion in hard palate
Authors: Molini Patricia Roccon Bianchi , Velloso Tânia Regina Grao , Silva Daniela Nascimento , Bertollo Rossiene Motta , Azevedo Sergio Lins Vaz de , Pereira Teresa Cristina Rangel , Barros Liliana Aparecida Pimenta de
Published: February 2017

Oral pigmented lesions are commonly noted in odontologic practice. Clinical features of malignant and benign lesions show enough similarity that makes clinical differentiation difficult or impossible. Exogenous pigmentations in orign are usually due to a foreign-body implantation in the oral mucosa and the graphite as an exogenous source of pigmentation in the oral cavity has been reported sporadically. This report is presents a case of a graphite tattoo in hard palate of a young female adult and discusses the diferential diagnosis with blue nevus and early oral melanoma. It reinforces that oral pigmented lesions must be carefully evaluated and a malignant lesion should not be ignored until a final diagnosis be established.
Enlargement of the genial tubercles
Authors: Oliveira Luciana Soares de Andrade Freitas , Vidal Manuela Torres Andion , Valverde Ludmila Faro , Crusoé-Rebello Iêda Margarida
Published: February 2017

The genial tubercles are small bony protuberances located in the cortical lingual of the mandible, in the midline. The enlargement of the genial tubercles is more common in edentulous mandibles exhibiting bone resorption, is generally asymptomatic and diagnosed by routine imaging methods. This study describes a case of enlargement of the genial tubercles detected by cone-beam computed tomography prior to the placement of dental implants. Cone-beam computed tomography showed an unusual increase in size and volume on the inner surface of the mandible, in the midline, which had a pedunculated aspect and was similar in density to cortical bone, suggested enlargement of the genial tubercles. In conclusion, this bone prominence should be observed during the planning of rehabilitation treatment since its presence can influence the adaptation of dentures. Additionally, patients should be monitored regarding painful symptoms and the presence of fractures, with surgical removal being required in some cases.
Early Detection of a Calcifying Cystic Odontogenic Tumor associated with Odontoma
Authors: Esteves Camilla Vieira , Florezi Giovanna Piacenza , Costa Sabrina Araújo Pinho , Trierveiler Marilia , Pelissari Cibele
Published: February 2017

A 15-year-old male patient was referred for diagnosis and treatment of a radiographic lesion located in the anterior region of the maxilla. Clinically, the patient presented a prolonged retention of the element 63 and absence of the element 23. No swelling around the alveolar ridge was observed. The radiographic findings were characterized by few tooth-like radiopaque structures surrounded by a radiolucent halo around the impacted element 23. The clinical hypothesis was stablished as dentigerous cyst associated with compound odontoma. The excisional biopsy was performed keeping the impacted tooth in place, to which an orthodontic bracket was bond for posterior traction. The surgical piece was taken to histopathological examination and the final diagnosis was calcifying cystic odontogenic tumor (CCOT) associated with compound odontoma. The calcifying cystic odontogenic tumor (CCOT) is a rare benign neoplastic lesion that represents less than 2% of all cysts and odontogenic tumors; it is usually found at the canine region and is associated with odontoma. Knowledge on the lesion characteristics, a detailed clinical exam, and complementary exams are essential to a differential diagnosis aiming to provide appropriate treatment for the patient, which currently consists of complete enucleation, with good prognosis. The 12-month follow-up shows an injury-free patient
Qui a peur d’être désuet et quétaine ?
Authors: Boisvert-Dufresne Élise
Published: February 2017

Cet article propose une étude de la réception de l’oeuvre d’André Belleau, qui est marquée par l’acquisition progressive d’un statut d’écrivain par celui-ci. Le travail de théorisation de l’essai entrepris par Belleau lui-même modifie de manière évidente la lecture de ses oeuvres et en permet une évaluation esthétique, qui gagnera progressivement en légitimité au fil du temps, sans jamais s’imposer entièrement.
« Un essaim d’idées-mots »
Authors: Riendeau Pascal
Published: February 2017

Cet article vise à approfondir notre connaissance des idées d’André Belleau sur l’essai à travers une lecture détaillée de trois textes : « Approches et situation de l’essai québécois », « Petite essayistique » et « La passion de l’essai ». L’auteur y étudie à la fois la conception de l’essai de Belleau et l’argumentation qu’il déploie pour mieux le circonscrire. Adoptant une approche prospective, il analyse les hypothèses de Belleau qui ont été le plus souvent citées (autour de la narrativité et de l’univers idéel), tout en cherchant à découvrir des éléments pertinents qui auraient pu échapper à la critique. Il cherche à mieux comprendre la manière de Belleau, qui consiste, entre autres, à reformuler la pensée de certains auteurs (principalement Barthes), ce qui le conduit à faire tenir le monde des idées dans un ensemble de formules originales. L’article se termine par une ouverture vers d’autres propositions intéressantes de Belleau qui semblent pourtant n’avoir trouvé aucun écho dans les travaux sur l’essai.
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
Authors: Chen Huaibin , Marsiglia William M , Cho Min-Kyu , Huang Zhifeng , Deng Jingjing , Blais Steven P , Gai Weiming , Bhattacharya Shibani , Neubert Thomas A , Traaseth Nathaniel J , Mohammadi Moosa
Published: February 2017

Receptor tyrosine kinase (RTK) signaling is tightly regulated by protein allostery within the intracellular tyrosine kinase domains. Yet the molecular determinants of allosteric connectivity in tyrosine kinase domain are incompletely understood. By means of structural (X-ray and NMR) and functional characterization of pathogenic gain-of-function mutations affecting the FGF receptor (FGFR) tyrosine kinase domain, we elucidated a long-distance allosteric network composed of four interconnected sites termed the ‘molecular brake’, ‘DFG latch’, ‘A-loop plug’, and ‘αC tether’. The first three sites repress the kinase from adopting an active conformation, whereas the αC tether promotes the active conformation. The skewed design of this four-site allosteric network imposes tight autoinhibition and accounts for the incomplete mimicry of the activated conformation by pathogenic mutations targeting a single site. Based on the structural similarity shared among RTKs, we propose that this allosteric model for FGFR kinases is applicable to other RTKs.
Causes and Effects of Begging Style Involving Children as Guides in Dodoma Municipality, Tanzania: Liability in Basic Education Access
Authors: Jacob Seni Abdallah
Published: February 2017

This paper explores the causes and effects of a unique begging style involving children as guides in Dodoma Municipality, Tanzania. The rationale for Dodoma Municipality to be the study location is that the begging phenomenon using children as guides is rampant. The study sample involved 40 respondents, of whom 6 were young carers of visually impaired adult beggars, 6 visually impaired adult beggars, 6 young carers of visually impaired adult beggars’ family members and 22 influential community members. Purposeful sampling technique was used to obtain these respondents. Data collection methods entailed interviews and observations. Artifacts were also used to portray issues under investigation more vividly. The data were analyzed using content analysis in which themes and sub-themes were determined by organization, reduction and interpretation of the information collected.   The study discovered that lack of education, sympathy attraction, lack of proper orientation, laziness and poverty were the major causes for the existence of begging involving children as guides. The study revealed that minor causes include parents’ negligence and alcoholism, Single Parenthood as well as drought and hunger. The begging style using children as guides resulted into notable limited basic education access among these vulnerable children hence a liability and not asset. The study recommends that young carers of visually impaired adult beggars should be enrolled to basic education and revitalize education for self-reliance.
Demographic, ecological, and physiological responses of ringed seals to an abrupt decline in sea ice availability
Authors: Ferguson Steven H. , Young Brent G. , Yurkowski David J. , Anderson Randi , Willing Cornelia , Nielsen Ole
Published: February 2017

To assess whether demographic declines of Arctic species at the southern limit of their range will be gradual or punctuated, we compared large-scale environmental patterns including sea ice dynamics to ringed seal (Pusa hispida) reproduction, body condition, recruitment, and stress in Hudson Bay from 2003 to 2013. Aerial surveys suggested a gradual decline in seal density from 1995 to 2013, with the lowest density occurring in 2013. Body condition decreased and stress (cortisol) increased over time in relation to longer open water periods. The 2010 open water period in Hudson Bay coincided with extremes in large-scale atmospheric patterns (North Atlantic Oscillation, Arctic Oscillation, El Nino-Southern Oscillation) resulting in the earliest spring breakup and the latest ice formation on record. The warming event was coincident with high stress level, low ovulation rate, low pregnancy rate, few pups in the Inuit harvest, and observations of sick seals. Results provide evidence of changes in the condition of Arctic marine mammals in relation to climate mediated sea ice dynamics. We conclude that although negative demographic responses of Hudson Bay seals are occurring gradually with diminishing sea ice, a recent episodic environmental event played a significant role in a punctuated population decline.
Comparison of Assessment Methods for Fallopian Tubal Patency and Peritubal Adhesion Between Transvaginal 4‐Dimensional Hysterosalpingo‐Contrast Sonography and Laparoscopic Chromopertubation
Authors: He Yanni , Ma Xiaohui , Xu Jingjiao , Li Sushu , Wu Haorong , Liu Qiuxiang , Kong Linghong , Luo Juan , Liu Hongmei
Published: February 2017

Objectives

The purpose of this study was to compare transvaginal 4‐dimensional hysterosalpingo‐contrast sonography with laparoscopic chromopertubation and evaluate the former's clinical value in assessing fallopian tubal patency and peritubal adhesion.

Methods

Fifty‐six patients visiting infertility clinics were included in the study and underwent surgery by their own choice in 1 month. In total, 112 fallopian tubes were assessed. Twenty‐five were primarily infertile, and the rest were secondarily infertile. Laparoscopic chromopertubation was taken as the reference standard.

Results

In a comparison of fallopian tubal patency between transvaginal hysterosalpingo‐contrast sonography and laparoscopic chromopertubation, the sensitivity, specify, positive predictive value, and negative predictive value of hysterosalpingo‐contrast sonography for diagnosing blocked fallopian tubes were 88.4%, 85.2%, 90.5%, and 82.1% respectively. In a comparison of spray at the fimbrial end between the no–peritubal adhesion and peritubal adhesion groups, the spray score at the fimbrial end in the no–peritubal adhesion group was significantly lower than that in the peritubal adhesion group. In a comparison of periovarian diffusion between the no–peritubal adhesion and peritubal adhesion groups, the periovarian diffusion score in the no–peritubal adhesion group was significantly lower than that in the peritubal adhesion group. In a comparison of periovarian diffusion between the patent‐tube and blocked groups confirmed by chromopertubation, the periovarian diffusion score in the patent group was significantly lower than that in the blocked group.

Conclusions

Transvaginal hysterosalpingo‐contrast sonography is a method with high sensitivity and specificity for screening fallopian tubal patency and peritubal adhesion.
Dotierte Halbleiter‐Nanokristalle: Lumineszenz, plasmonische und magnetische Eigenschaften
Authors: Pradhan Narayan , Das Adhikari Samrat , Nag Angshuman , Sarma D. D.
Published: February 2017

Der Einbau bereits weniger Fremdatome in Halbleiter‐Nanokristalle kann zu einer drastischen Änderung der Eigenschaften oder gar dem Auftreten gänzlich neuer Eigenschaften führen. Zum Beispiel haben Mid‐Gap‐Zustände, die durch Dotierung generiert werden, einen enormen Einfluss auf die photokatalytische Aktivität und oberflächenkontrollierte Redoxreaktionen. Fremdatome/Dotanden erzeugen neue Emissionszentren, ermöglichen thermometrisches optisches Schaltverhalten, erhöhen die Lebensdauer der angeregten Zustände von FRET‐Donoren und erzeugen niederenergetische Absorptionen induziert durch lokalisierte Oberflächenplasmonenresonanzen. Dotierte Nanokristalle werden seit kurzem außerdem als Materialien für die Umwandlung von Sonnenenergie erforscht. Ferner werden auch die elektrischen und magnetischen Eigenschaften des Wirtmaterials durch Dotierung stark verändert. Diese vorteilhaften fremdatominduzierten Modifikationen machen dotierte Nanokristalle mit passenden Dotand‐Wirt‐Paaren zu geeigneten Kandidaten für die gezielte Herstellung von Materialien mit bestimmten Eigenschaften für eine breite Auswahl von Technologien. Die Zusammenhänge zwischen den Eigenschaften von Halbleiter‐Nanokristallen und ihrer Dotierung sind Gegenstand dieses Aufsatzes.
By‐Product‐Free Siloxane‐Bond Formation and Programmed One‐Pot Oligosiloxane Synthesis
Authors: Matsumoto Kazuhiro , Sajna Kappam Veettil , Satoh Yasushi , Sato Kazuhiko , Shimada Shigeru
Published: February 2017

Siloxane bonds are usually synthesized by condensation reactions, such as hydrolysis/dehydration and cross‐coupling reactions, in which the generation of by‐products during bond formation can not be avoided. We have developed a one‐pot sequence of iridium‐catalyzed silyl ester hydrosilylation and boron‐catalyzed rearrangement of the resulting disilyl acetals for the construction of siloxane bonds, in principle without the formation of any by‐products. Moreover, the programmed synthesis of tri‐, tetra‐, and pentasiloxanes was possible in a single flask by combining the above sequence of iridium‐catalyzed hydrosilylation and boron‐catalyzed rearrangement with a boron‐catalyzed cross‐coupling reaction. The obtained oligosiloxanes are difficult to synthesize selectively by other known synthetic procedures.
The effect of vortioxetine on overall patient functioning in patients with major depressive disorder
Authors: Florea Ioana , Loft Henrik , Danchenko Natalya , Rive Benoît , Brignone Melanie , Merikle Elizabeth , Jacobsen Paula L. , Sheehan David V.
Published: February 2017

Background

The objectives of this meta‐analysis of data from randomized, placebo‐controlled studies were to assess the effect of vortioxetine on overall functioning (primary) and functional remission (secondary) using the Sheehan Disability Scale (SDS) in adults with major depressive disorder (MDD).

Methods

Data from nine short‐term (6/8 weeks) pivotal studies that included patient functioning assessments were included in this random‐effects meta‐analysis, which used aggregated study‐level data for all therapeutic vortioxetine doses and a mixed‐effect model for repeated measures using the full analysis set.

Results

A total of 4,216 patients received ≥1 dose of study treatment (1,522 placebo, 2,694 vortioxetine 5–20 mg/day). At study end, the meta‐analysis showed improvement for vortioxetine versus placebo (n = 911) in SDS total score (vortioxetine 5 mg, n = 564, change from baseline versus placebo [Δ] −0.24, p = NS; 10 mg, n = 445, Δ −1.68, p ≤ .001; 15 mg, n = 204, Δ −0.91, p = NS; 20 mg, n = 340, Δ −1.94, p ≤ .01). Functional remission (SDS total score ≤6) was observed with vortioxetine 10 mg (n = 170/573; odds ratio [OR] relative to placebo 1.7, p < .001) and 20 mg (n = 144/447; OR 1.6, p < .05), but not 5 mg (n = 207/757; OR 1.1, p = NS) or 15 mg (n = 92/295; OR 1.3, p = NS).

Conclusion

Vortioxetine 5–20 mg for 6/8 weeks improved overall patient functioning in patients with MDD. Relative to placebo, vortioxetine 10 and 20 mg demonstrated significant improvement in SDS total score and functional remission.
Cyclodextrin Nanoparticles Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Biomaterials
Authors: Oliveri Valentina , Bellia Francesco , Vecchio Graziella
Published: February 2017

Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal‐chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal‐chelating β‐cyclodextrin polymer bearing 8‐hydroxyquinoline ligands. The metal ions (Cu2+ or Zn2+) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self‐ and metal‐induced Aβ aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble β‐cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.
Das Innere der Zelle: Ein komplexes Lösungsmittel
Authors: Heyden Matthias , Ebbinghaus Simon , Winter Roland
Published: February 2017

Bisher erlauben nur wenige, meist komplexe Techniken, Biomoleküle in zellulärer Umgebung zu untersuchen. Doch es ist klar, dass es in einigen Fällen deutliche Unterschiede zwischen einem verdünnten Puffer und dem komplexen zellulären Milieu geben kann. Diese Unterschiede zu verstehen und sie im biologischen Kontext zu bewerten, wird Aufgabe zukünftiger Studien und Modelle sein. Dabei können neue Techniken wie In‐Zell‐NMR oder FReI helfen, krankheitsrelevante Mechanismen aufzudecken und neue Therapeutika bzw. Therapie‐Ansätze zu entwerfen und zu testen. Es wird deutlich, dass die Zelle als komplexes Lösungsmittel nicht nur eine passive Umgebung darstellt, sondern wichtiger Bestandteil biomolekularer Prozesse ist. Die Kenntnis der biochemischen Anpassungen des zellulären Milieus, die Organismen entwickeln, um extreme Lebensräume zu erobern, hilft, die Lebensvorgänge unter Extrembedingungen besser zu verstehen sowie für biotechnologische Anwendungen nutzbar zu machen.
The economic case for digital interventions for eating disorders among United States college students
Authors: Kass Andrea E. , Balantekin Katherine N. , Fitzsimmons‐Craft Ellen E. , Jacobi Corinna , Wilfley Denise E. , Taylor C. Barr
Published: February 2017

Objective

Eating disorders (EDs) are serious health problems affecting college students. This article aimed to estimate the costs, in United States (US) dollars, of a stepped care model for online prevention and treatment among US college students to inform meaningful decisions regarding resource allocation and adoption of efficient care delivery models for EDs on college campuses.

Methods

Using a payer perspective, we estimated the costs of (1) delivering an online guided self‐help (GSH) intervention to individuals with EDs, including the costs of “stepping up” the proportion expected to “fail”; (2) delivering an online preventive intervention compared to a “wait and treat” approach to individuals at ED risk; and (3) applying the stepped care model across a population of 1,000 students, compared to standard care.

Results

Combining results for online GSH and preventive interventions, we estimated a stepped care model would cost less and result in fewer individuals needing in‐person psychotherapy (after receiving less‐intensive intervention) compared to standard care, assuming everyone in need received intervention.

Conclusions

A stepped care model was estimated to achieve modest cost savings compared to standard care, but these estimates need to be tested with sensitivity analyses. Model assumptions highlight the complexities of cost calculations to inform resource allocation, and considerations for a disseminable delivery model are presented. Efforts are needed to systematically measure the costs and benefits of a stepped care model for EDs on college campuses, improve the precision and efficacy of ED interventions, and apply these calculations to non‐US care systems with different cost structures.
Anchoring and Probability Weighting in Option Prices
Authors: DeLisle R. Jared , Diavatopoulos Dean , Fodor Andy , Krieger Kevin
Published: February 2017

Cumulative prospect theory argues that the human decision‐making process tends to improperly weight unlikely events. Another behavioral phenomenon, anchoring bias, is the failure to update beliefs away from established anchor points. In this study, we find evidence that equity option market investors both anchor to prices and incorporate a probability weighting function similar to that proposed by cumulative prospect theory. The biases result in inefficient prices for put options when firms have relatively high or relatively low implied volatilities. This has implications for the cost of hedging long portfolios and long individual equity positions. © 2017 Wiley Periodicals, Inc. Jrl Fut Mark 37:614–638, 2017
Complementary actions of dopamine D2 receptor agonist and anti‐vegf therapy on tumoral vessel normalization in a transgenic mouse model
Authors: Chauvet Norbert , Romanò Nicola , Lafont Chrystel , Guillou Anne , Galibert Evelyne , Bonnefont Xavier , Le Tissier Paul , Fedele Monica , Fusco Alfredo , Mollard Patrice , Coutry Nathalie
Published: February 2017

Angiogenesis contributes in multiple ways to disease progression in tumors and reduces treatment efficiency. Molecular therapies targeting Vegf signaling combined with chemotherapy or other drugs exhibit promising results to improve efficacy of treatment. Dopamine has been recently proposed to be a novel safe anti‐angiogenic drug that stabilizes abnormal blood vessels and increases therapeutic efficacy. Here, we aimed to identify a treatment to normalize tumoral vessels and restore normal blood perfusion in tumor tissue with a Vegf receptor inhibitor and/or a ligand of dopamine G protein‐coupled receptor D2 (D2R). Dopamine, via its action on D2R, is an endogenous effector of the pituitary gland, and we took advantage of this system to address this question. We have used a previously described Hmga2/T mouse model developing haemorrhagic prolactin‐secreting adenomas. In mutant mice, blood vessels are profoundly altered in tumors, and an aberrant arterial vascularization develops leading to the loss of dopamine supply. D2R agonist treatment blocks tumor growth, induces regression of the aberrant blood supply and normalizes blood vessels. A chronic treatment is able to restore the altered balance between pro‐ and anti‐angiogenic factors. Remarkably, an acute treatment induces an upregulation of the stabilizing factor Angiopoietin 1. An anti‐Vegf therapy is also effective to restrain tumor growth and improves vascular remodeling. Importantly, only the combination treatment suppresses intratumoral hemorrhage and restores blood vessel perfusion, suggesting that it might represent an attractive therapy targeting tumor vasculature. Similar strategies targeting other ligands of GPCRs involved in angiogenesis may identify novel therapeutic opportunities for cancer.
Analysis of the Performance of Government Investment and Interventions to Promote Small‐Scale Irrigation Works in China's Major Grain‐Producing Areas‐Based on the Two‐Step Model of Malmquist‐FGLS
Authors: Luo Fang , Ma Weimin , Sun Caihong , Tian Miao , Zhou Yewang
Published: February 2017

China's major grain‐producing areas have the important role of ensuring the nation's grain security. Farmland water conservation projects, which are financed by government investment and promoted by additional government policies, are vital for grain and agricultural production. Analysing the determinants of good performance of farmland water conservation, and the performance of government investments and interventions in major grain‐producing areas, are important for understanding whether the scale and structure of investment are reasonable and, hence, efficient.

We apply the data envelopment analysis (DEA) Malmquist index method and panel data feasible generalized least squares (FGLS) model to data from China's major grain‐producing areas between 1990 and 2014. Based on this two‐step Malmquist and FGLS model, we estimate the performance of farmland water conservation and the determinants of performance, emphasizing the effects of government investment and other public policies.

The results show that current investment policies do not result in efficient performance in farmland water conservation projects. The scale of investment is too small and its structure needs to be adjusted. In contrast, increasing the level of economic development promotes the performance of these investments. However, rural education focusing on urban jobs rather than on modern farming skills pulls in the opposite direction. Copyright © 2017 John Wiley & Sons, Ltd.
Initial and Follow‐Up Evaluations of Integrated Psychological Services for Anxiety and Depression in a Safety Net Primary Care Clinic
Authors: Sadock Elizabeth , Perrin Paul B. , Grinnell Renée M. , Rybarczyk Bruce , Auerbach Stephen M.
Published: February 2017

Objective

Despite the recognized importance of integrated behavioral health, particularly in safety net primary care, its effectiveness in real world settings has not been extensively evaluated. This article presents 2 successive studies examining the effectiveness of integrated behavioral care in a safety net setting.

Method

Study 1 compared the depression and anxiety scores of predominately low‐income and minority patients who underwent brief interventions (N = 147) to those of patients from a demographically similar comparison clinic without integrated psychological services, matched on baseline levels of anxiety and depression and length of time between assessments (N = 139). Study 2 did not include a control group but served as a long‐term follow‐up assessment of anxiety and depression for a subset of 47 patients who finished treatment and could be reached by telephone within 6–18 months of their last session.

Results

Study 1 found that patients from the clinic with integrated psychology services experienced greater decreases in depression and anxiety scores than patients in the control clinic. These effects did not differ as a function of age, gender, or race. Study 2 found that patients continued to decline in depression and anxiety over time, with lower scores at the last session and even lower scores after longer‐term follow‐up ranging from 6 to18 months. These improvements remained significant when controlling for other interim mental health treatments.

Conclusion

These results support the short‐ and long‐term treatment effects of brief primary care behavioral interventions, further strengthening the case for integrated behavioral healthcare in safety net settings.
Assessment of maximal handgrip strength: how many attempts are needed?
Authors: Reijnierse Esmee M. , de Jong Nynke , Trappenburg Marijke C. , Blauw Gerard Jan , Butler‐Browne Gillian , Gapeyeva Helena , Hogrel Jean‐Yves , McPhee Jamie S. , Narici Marco V. , Sipilä Sarianna , Stenroth Lauri , van Lummel Rob C. , Pijnappels Mirjam , Meskers Carel G.M. , Maier Andrea B.
Published: February 2017

Background

Handgrip strength (HGS) is used to identify individuals with low muscle strength (dynapenia). The influence of the number of attempts on maximal HGS is not yet known and may differ depending on age and health status. This study aimed to assess how many attempts of HGS are required to obtain maximal HGS.

Methods

Three cohorts (939 individuals) differing in age and health status were included. HGS was assessed three times and explored as continuous and dichotomous variable. Paired t‐test, intraclass correlation coefficients (ICC) and Bland–Altman analysis were used to test reproducibility of HGS. The number of individuals with misclassified dynapenia at attempts 1 and 2 with respect to attempt 3 were assessed.

Results

Results showed the same pattern in all three cohorts. Maximal HGS at attempts 1 and 2 was higher than at attempt 3 on population level (P < 0.001 for all three cohorts). ICC values between all attempts were above 0.8, indicating moderate to high reproducibility. Bland–Altman analysis showed that 41.0 to 58.9% of individuals had the highest HGS at attempt 2 and 12.4 to 37.2% at attempt 3. The percentage of individuals with a maximal HGS above the gender‐specific cut‐off value at attempt 3 compared with attempts 1 and 2 ranged from 0 to 50.0%, with a higher percentage of misclassification in middle‐aged and older populations.

Conclusions

Maximal HGS is dependent on the number of attempts, independent of age and health status. To assess maximal HGS, at least three attempts are needed if HGS is considered to be a continuous variable. If HGS is considered as a discrete variable to assess dynapenia, two attempts are sufficient to assess dynapenia in younger populations. Misclassification should be taken into account in middle‐aged and older populations.
Portal systemic shunt between the hepatic portal vein and right renal vein in a patient with multifocal hepatocellular carcinoma: Case report
Authors: Sabol Pušić Mateja , Budimir Ivan , Dorosulić Zdravko , Ostrički Branko , Nikolić Marko , Lovrenčić Prpić Gordana , Sreter Katherina B.
Published: February 2017

Portal hypertension is a clinical syndrome characterized by the development of collateral circulation and portosystemic shunts, as well as ascites and hepatic encephalopathy. We present the case of a large portosystemic shunt between the hepatic portal vein and aneurysmal right renal vein in a cirrhotic 64‐year‐old man with thrombosis of the portal vein and hepatocellular carcinoma. This is a very rare clinical manifestation which, to our knowledge, has been described only once previously in the literature. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:524–527, 2017
Hamiltonicity and Degrees of Adjacent Vertices in Claw‐Free Graphs
Authors: Chen Zhi‐Hong
Published: February 2017

For a graph H, let for every edge . For and , let be a set of k‐edge‐connected K3‐free graphs of order at most r and without spanning closed trails. We show that for given and ε, if H is a k‐connected claw‐free graph of order n with and , and if n is sufficiently large, then either H is Hamiltonian or the Ryjác̆ek's closure where G is an essentially k‐edge‐connected K3‐free graph that can be contracted to a graph in . As applications, we prove:

For , if and if and n is sufficiently large, then H is Hamiltonian.

For , if and n is sufficiently large, then H is Hamiltonian.

These bounds are sharp. Furthermore, since the graphs in are fixed for given p and can be determined in a constant time, any improvement to (i) or (ii) by increasing the value of p and so enlarging the number of exceptions can be obtained computationally.
Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission
Authors: Murphy‐Royal Ciaran , Dupuis Julien , Groc Laurent , Oliet Stéphane H. R.
Published: February 2017

Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain function and have been implicated in various disorders of the central nervous system. These cells are involved in a wide range of cerebral processes including brain metabolism, control of central blood flow, ionic homeostasis, fine‐tuning synaptic transmission, and neurotransmitter clearance. Such varied roles can be efficiently carried out due to the intimate interactions astrocytes maintain with neurons, the vasculature, as well as with other glial cells. Arguably, one of the most important functions of astrocytes in the brain is their control of neurotransmitter clearance. This is particularly true for glutamate whose timecourse in the synaptic cleft needs to be controlled tightly under physiological conditions to maintain point‐to‐point excitatory transmission, thereby limiting spillover and activation of more receptors. Most importantly, accumulation of glutamate in the extracellular space can trigger excessive activation of glutamatergic receptors and lead to excitotoxicity, a trademark of many neurodegenerative diseases. It is thus of utmost importance for both physiological and pathophysiological reasons to understand the processes that control glutamate time course within the synaptic cleft and regulate its concentrations in the extracellular space. © 2017 Wiley Periodicals, Inc.
Trend analysis of monthly mean values and extreme indices of daily temperature in a region of southern Italy
Authors: Caloiero T. , Coscarelli R. , Ferrari E. , Sirangelo B.
Published: February 2017

The analyses of temperature extremes can be very useful because they are highly representative of the climatic tendency of an area. In this study, 19 temperature series registered in southern Italy have been analysed for detecting trends through the Mann–Kendall non‐parametric test. The tendencies have been detected since 1951 for the maximum and minimum monthly temperatures and for several indices of daily extremes. As a result, the minimum and maximum monthly temperatures mainly denote a positive trend for spring and summer months and a marked negative one in September. Moreover, the trend analysis on the extreme temperature indices shows opposite behaviours: a clear positive tendency in the frequency and intensity of the highest values and some negative trends for the lowest ones.
Existence and exact controllability of fractional evolution inclusions with damping
Authors: Li Xiuwen , Liu Zhenhai , Tisdell C. C.
Published: February 2017

The aim of this paper is to deal with the existence of mild solutions and exact controllability for a class of fractional evolution inclusions with damping (FEID, for short) in Banach spaces. Firstly, we provide the representation of mild solutions for FEID by applying the method of Laplace transform and the theory of (α,κ)‐regularized families of operators. Next, we are concerned with the existence and exact controllability of FEID under some suitable sufficient conditions by using the method of measure of noncompactness and an appropraite fixed point theorem. Finally, an application to nonlinear partial differential equations with temporal fractional derivatives is presented to illustrate the effectiveness of our main results. Copyright © 2017 John Wiley & Sons, Ltd.
Cross‐cultural measurement invariance of the General Health Questionnaire‐12 in a German and a Colombian population sample
Authors: Romppel Matthias , Hinz Andreas , Finck Carolyn , Young Jeremy , Brähler Elmar , Glaesmer Heide
Published: February 2017

While the General Health Questionnaire, 12‐item version (GHQ‐12) has been widely used in cross‐cultural comparisons, rigorous tests of the measurement equivalence of different language versions are still lacking. Thus, our study aims at investigating configural, metric and scalar invariance across the German and the Spanish version of the GHQ‐12 in two population samples. The GHQ‐12 was applied in two large‐scale population‐based samples in Germany (N = 1,977) and Colombia (N = 1,500). To investigate measurement equivalence, confirmatory factor analyses were conducted in both samples. In the German sample mean GHQ‐12 total scores were higher than in the Colombian sample. A one‐factor model including response bias on the negatively worded items showed superior fit in the German and the Colombian sample; thus both versions of the GHQ‐12 showed configural invariance. Factor loadings and intercepts were not equal across both samples; thus GHQ‐12 showed no metric and scalar invariance. As both versions of the GHQ‐12 did not show measurement equivalence, it is not recommendable to compare both measures and to conclude that mental distress is higher in the German sample, although we do not know if the differences are attributable to measurement problems or represent a real difference in mental distress. The study underlines the importance of measurement equivalence in cross‐cultural comparisons.
Controlling Nucleation and Growth of Metal Halide Perovskite Thin Films for High‐Efficiency Perovskite Solar Cells
Authors: Sakai Nobuya , Wang Zhiping , Burlakov Victor M. , Lim Jongchul , McMeekin David , Pathak Sandeep , Snaith Henry J.
Published: February 2017

Metal halide perovskite thin films can be crystallized via a broad range of solution‐based routes. However, the quality of the final films is strongly dependent upon small changes in solution composition and processing parameters. Here, this study demonstrates that a fractional substitution of PbCl2 with PbI2 in the 3CH3NH3I:PbCl2 mixed‐halide starting solution has a profound influence upon the ensuing thin‐film crystallization. The presence of PbI2 in the precursor induces a uniform distribution of regular quadrilateral‐shaped CH3NH3PbI3 perovskite crystals in as‐cast films, which subsequently grow to form pinhole‐free perovskite films with highly crystalline domains. With this new formulation of 3CH3NH3I:0.98PbCl2:0.02PbI2, this study achieves a 19.1% current–voltage measured power conversion efficiency and a 17.2% stabilized power output in regular planar heterojunction solar cells.
The effect of temperature, gradient, and load carriage on oxygen consumption, posture, and gait characteristics
Authors: Hinde Katrina , Lloyd Ray , Low Chris , Cooke Carlton
Published: February 2017

Purpose

The purpose of this experiment was to evaluate the effect of load carriage in a range of temperatures to establish the interaction between cold exposure, the magnitude of change from unloaded to loaded walking and gradient.

Methods

Eleven participants (19–27 years) provided written informed consent before performing six randomly ordered walking trials in six temperatures (20, 10, 5, 0, −5, and −10 °C). Trials involved two unloaded walking bouts before and after loaded walking (18.2 kg) at 4 km · h−1, on 0 and 10% gradients in 4 min bouts.

Results

The change in absolute oxygen consumption (V̇O2) from the first unloaded bout to loaded walking was similar across all six temperatures. When repeating the second unloaded bout, V̇O2at both −5 and −10 °C was greater compared to the first. At −10 °C, V̇O2was increased from 1.60 ± 0.30 to 1.89 ± 0.51 L · min−1. Regardless of temperature, gradient had a greater effect on V̇O2and heart rate (HR) than backpack load. HR was unaffected by temperature. Stride length (SL) decreased with decreasing temperature, but trunk forward lean was greater during cold exposure.

Conclusion

Decreased ambient temperature did not influence the magnitude of change in V̇O2from unloaded to loaded walking. However, in cold temperatures, V̇O2was significantly higher than in warm conditions. The increased V̇O2in colder temperatures at the same exercise intensity is predicted to ultimately lead to earlier onset of fatigue and cessation of exercise. These results highlight the need to consider both appropriate clothing and fitness during cold exposure.
Diagnosis of variant RARA translocation using standard dual-color dual-fusion PML/RARA FISH probes
Authors: Singh Manish Kumar , Parihar Mayur , Arora Neeraj , Mishra Deepak Kumar , Bhave Saurabh Jayant , Chandy Mammen
Published: February 2017

Acute promyelocytic leukemia (APML) with variant RARa translocations comprises 1–2% of APML cases. However, the diagnosis of these cases is challenging as the routine practice includes fluorescence in situ hybridization (FISH) reverse transcription polymerase chain reaction targeting the PML and RARA genes to detect PML/RARA fusions. Here, we report a case highlighting the importance of atypical FISH signal patterns in standard dual-color dualfusion PML/RARa FISH analysis complimented by karyotyping to detect these variant RARA translocations.
An eighteenth-century theme park: museum-reserve Tsaritsyno (Moscow) and the public culture of the post-Soviet metropolis
Authors: STEPANOV BORIS , SAMUTINA NATALIA
Published: February 2017

The article discusses the dramatic history of the Tsaritsyno Park and museum-reserve. By the mid-2000s, it had become one of Moscow's iconic places and a zone where urban public culture was shaped. The authors trace the history of this architectural ensemble and park in terms of their role in сity culture and analyse changes in the historical culture of contemporary post-Soviet Moscow. The Tsaritsyno Park and museum exemplify these changes. An unfinished country residence of Catherine II, with a Grand Palace that had stood as a ruin for over 200 years, it has been radically renewed by the Moscow city authorities in what came to be labelled ‘fantasy restoration’. The palace was finished and now serves as the core of the museum, organized according to a controversial historical policy. Tsaritsyno as a whole became a cultural oddity featuring historical attractions for the public, effectively an ‘eighteenth-century theme park’.