bluuebunny/crossref_metadata_2025 huggingface dataset:
Lesson by SARS-Cov 2 disease (COVID-19): whole body CT angiography detection of relevant and other/incidental systemic vascular findings
Authors: Rea Gaetano , Lassandro Francesco , Lieto Roberta , Bocchini Giorgio , Romano Federica , Sica Giacomo , Valente Tullio , Muto Emanuele , Murino Patrizia , Pinto Antonio , Montesarchio Vincenzo , Muto Maurizio , Pacella Daniela , Capitelli Ludovica , Bocchino Marialuisa
Published: August 2020

Objectives: The aim of our study was to assess the frequency distribution of relevant and incidental vascular events in a retrospective cohort of 42 COVID-19 patients. Methods: All patients were studied by whole-body CT angiography.Twenty-three out of 42 patients were admitted to the intensive care unit (ICU). Results: Relevant vascular events were recorded in the 71.4% of the whole study population. Pulmonary embolism was the most frequent one both in ICU and no-ICU cases (56.5% vs10.5%, p=0.002). Ischemic infarction of other organs was affecting with an increasing prevalence the gut, the spleen, the liver, the brain and the kidney, with a simultaneous ischemic occurrence in some cases. Multi-focal venous thrombosis was also represented especially in ICU patients (p=0.005). Among incidental findings, splanchnic vessels little-size aneurysms were reported in the 40% of the whole population, with relative frequencies similarly distributed in ICU and no-ICU patients.Conclusions: Vascular involvement is not negligible in COVID-19 and should be carefully investigated as may significantly affect disease behavior and prognosis.
A Two-stage Panel Data Envelopment Analysis Models: Wallace-Hussain, Amemiya and Swamy-Arora
Authors: Shaik Saleem
Published: August 2020

This research presents two-stage panel data envelopment analysis (DEA) models for the estimation of efficiency measures. In the first stage, the variances of normal errors, v used in the transformation of the variables are recovered from pooled (Wallace-Hussain in 1969); within (Amemiya in 1971); or within, cross-sectional and time-series (Swamy-Arora in 1972) stochastic frontier analysis (SFA) models. The second stage involves estimating panel DEA efficiency measures using transformed data based on alternative two-way random effect econometric estimators in the first stage. The alternative panel DEA models might over- or under-estimate the pooled DEA model estimated efficiency measure due to the non-existence or existence of the spatial and temporal variations. An empirical application to 48 U.S. states from 1960 to 2004 suggests differences in the efficiency measure estimated by the pooled and panel DEA models. In addition, the efficiency measure estimated by the Swamy-Arora panel estimator is statistically different compared to the Wallace-Hussain and Amemiya panel estimator.
A Computational Framework to Quantify Host-Microbiome Interactions in Clostridioides Difficile Infection
Authors: Ke Shanlin , Pollock Nira R. , Wang Xu-wen , Chen Xinhua , Daugherty Kaitlyn , Lin Qianyun , Xu Hua , Garey Kevin W. , Gonzales-Luna Anne J. , Liu Yang-Yu , Kelly Ciarán P.
Published: August 2020

Background: Clostridioides difficile infection (CDI) is the most common cause of healthcare–associated infection and an important cause of morbidity and mortality among hospitalized patients. A comprehensive understanding of C. difficile infection (CDI) pathogenesis is crucial for disease diagnosis, treatment and prevention. To achieve that, a quantitative study of host-microbiome interactions in CDI is a prerequisite. Yet, an effective computational framework to quantify host-microbiome interactions in CDI was lacking. Methods: Here, we characterized gut microbial compositions and abroad panel of immunological markers in a comprehensive clinical cohort of 243 well-characterized human subjects with four different C. difficile infection/colonization statuses (CDI, Asymptomatic Carriage, Non-CDI Diarrhea, and Control). Based on microbial and immunological features, we developed a computational framework to detect CDI status using random forest and symbolic classification models.Results: First, by calculating the correlations between microbial compositions and the circulating levels of host immune markers for each of the four phenotype groups, we found that the interactions between gut microbiota and host immune markers are very sensitive to the status of C. difficile colonization and infection. Second, we demonstrated that incorporating both gut microbiome and host immune marker data into random forest classifiers can better distinguish CDI from other groups than can either type of data alone. Finally, we performed symbolic classification using selected features from random forest classifiers to derive simple mathematic formulas that explicitly model the interactions between gut microbiome and host immune markers.Conclusions: Overall, this study provides an effective computational framework to quantify the role of the intricate interactions between gut microbiota and host immune markers in CDI pathogenesis. This framework may inform the design of future diagnostic and therapeutic strategies.
Deep Learning Based Liver Cancer Segmentation from Computed Tomography Images
Authors: Ayalew Yodit Abebe , Fante Kinde Anlay , Aliy Mohammed
Published: August 2020

Background: Liver cancer is the sixth most common cancer worldwide. According to WHO data in 2017, the liver cancer death in Ethiopia reached 1040 (0.16%) from all cancer deaths. Hepatocellular carcinoma (HCC), primary liver cancer causes the death of around 700,000 people each year worldwide and this makes it the third leading cause of cancer death. HCC is occurred due to cirrhosis and hepatitis B or C viruses. Liver cancer mostly diagnosed with a computed tomography (CT) scan. But, the detection of the tumor from the CT scan image is difficult since tumors have similar intensity with nearby tissues and may have a different appearance depending on their type, state, and equipment setting. Nowadays deep learning methods have been used for the segmentation of liver and its tumor from the CT scan images and they are more efficient than those traditional methods. But, they are computationally expensive and need many labeled samples for training, which are difficult in the case of biomedical images. Results: A deep learning-based segmentation algorithm is employed for liver and tumor segmentation from abdominal CT scan images. Three separate UNet models, one for liver segmentation and the others two for tumor segmentation from the segmented liver and directly from the abdominal CT scan image were used. A dice score of 0.96 was obtained for liver segmentation. And a dice score of 0.74 and 0.63 was obtained for segmentation of tumor from the liver and from abdominal CT scan image respectively. Conclusion: The research improves the liver tumor segmentation that will help the physicians in the diagnosis and detection of liver tumors and in designing a treatment plan for the patient. And for the patient, it increases the patients’ chance of getting treatment and decrease the mortality rate due to liver cancer.
SARS-CoV-2: Enhancement and Segmentation of High-ResolutionMicroscopy Images. Part I
Authors: Rodriguez Roberto , Mondeja Brian A. , Valdes Odalys , Resik Sonia , Vizcaino Ananayla , Acosta Emilio F. , González Yorexis , Kourí Vivian , Díaz Angelina , Guzmán María G.
Published: August 2020

Possibly, and due to poor eating habits and unhealthy lifestyle, many virus are transmitted to human people. Such is the case, of the novel coronavirus SARS-Cov-2, which has expanded of exponential way, practically, to whole world population. For this reason, the study of real microscopic images of this coronavirus is of great importance. The SARS-Cov-2 images were captured from nasopharyngeal samples of Cuban symptomatic individuals (RT-PCR positives for SARS-CoV-2), and processed via scanning electron microscopy. However, many times these microscopic images present some blurring problems, which are always susceptible to be improved. The aim of this work is to propose new computational methods to carry out enhancement and segmentation of SARS-Cov-2 high-resolution microscopic images. Moreover, due to the importance of the obtained results, this first work will be addressed to the application of the proposed algorithm. The proposed strategy obtained very satisfactory results, and we validated its performance, together with specialist physicians, on a set of 1005 images. A second paper will deeply analyze the theory related to these algorithms
Membrane Protein Metabolism in UNG-Activated NCAPH and RFC4 Subnetworks for Viral HCC|blood Cancer Development Via Inside-Out Microtubule Binding
Authors: Wang Lin , Chen Qingchun , Feng Haitao , Jiang Minghu , Huang Juxiang , Jiang Zhenfu
Published: August 2020

Background: Our aim is to compute NCAPH and RFC4 subnetworks containing CDKN3 (feedback) for the novel molecular and cellular mechanisms of HCC (HBV or HCV) related cancer development from high UNG-activated upstream network.Methods: Non-SMC condensin I complex subunit H (NCAPH) and replication factor C subunit 4 (RFC4) common molecular and knowledge subnetworks containing cyclin-dependent kinase inhibitor 3-CDKN3 (feedback) related to cancer by references were identified in HCC (HBV or HCV), based on our established significant high expression uracil DNA glycosylase (UNG)-activated upstream Gene (protein) reconstruction network inference (GRNInfer) and Database for Annotation, Visualization and Integrated Discovery (DAVID).Results: Our results show the common molecules MAPT interaction with CDKN3 with RRM2 with HIST1H3H from UNG-activated upstream GRNInfer database; The common biological process and molecular function of MAPT as microtubule binding; HIST1H3H as cellular protein metabolic process from UNG-activated upstream DAVID database; The common cellular component of UNG, NCAPH, CDKN3, RRM2, HIST1H3H at nucleus; NCAPH, HIST1H3H at membrane; The common tissue distributions of NCAPH and RFC4 in Leukemiapromyelocytic(hl60), leukemialymphoblastic(molt4), etc.Conclusions: We propose and mutual positively verify membrane protein metabolism in UNG-activated NCAPH and RFC4 subnetworks for viral HCC|blood cancer development via inside-out microtubule binding.
New Records of Bartonella Spp. And Rickettsia Spp. In Lice Collected From Small Rodents
Authors: Aleksandravičienė Asta , Paulauskas Algimantas , Stanko Michal , Fričová Jana , Radzijevskaja Jana
Published: August 2020

Background: Lice are blood-sucking insects that are of medical and veterinary significance as parasites and vectors for various infectious agents. More than half of described blood-sucking lice species are found on rodents. Rodents are important hosts of several Bartonella and Rickettsia species and some of these pathogens are characterised as human pathogens in Europe. Rodent ectoparasites, such as fleas and ticks, are important vectors of Bartonella spp. and Rickettsia spp., but knowledge about the presence of these bacteria in lice is limited. The aim of this study was to determine the prevalence of Bartonella and Rickettsia bacteria in lice collected from rodents in Slovakia.Methods: The ectoparasites were collected from small rodents captured from 2010 to 2015 at four different sites in eastern Slovakia. The presence of Bartonella and Rickettsia pathogens in lice samples was screened by real-time PCR, targeting ssrA and gltA genes respectively. The molecular characterisation of the Bartonella strains was based on sequence analysis of partial rpoB and ITS genes, and of the Rickettsia species on sequence analysis of the gltA gene. Results: A total of 1074 lice of seven species were collected from six rodent species in Slovakia from 2010 to 2015. Bartonella DNA was detected in three species of lice Hoplopleura affinis (collected from Apodemus agrarius, A. flavicollis and Myodes glareolus), Polyplax serrata (from A. agrarius) and Hoplopleura sp. (from A. flavicollis). Sequence analysis revealed that the Bartonella strains belonged to the B. coopersplainsensis, B. tribocorum and B. taylorii genogroups. Rickettsia DNR was detected in H. affinis and P. serrata lice collected from A. agrarius. Sequence analysis revealed the presence of two Rickettsia species: R. helvetica and Rickettsia sp.Conclusions: To the best of the authors’ knowledge, this is the first report on the occurrence and diversity of Bartonella spp. and Rickettsia spp. in lice collected from small rodents in Europe. This study is also the first to detect B. coopersplainsensis in Slovakia.
3D Models Improve Understanding of Congenital Heart Disease
Authors: Awori Jonathan , Friedman Seth , Chan Titus , Howard Christopher , Seslar Stephen , Soriano Brian , Buddhe Sujatha
Published: August 2020

Introduction: Understanding congenital heart disease (CHD) is vital for medical personnel and parents of affected children. While traditional 2D schematics serve as the typical approach used, several studies have shown these models to be suboptimal. Recent world-emphasis has shifted to 3D printed models to bridge knowledge and create new opportunities for experiential learning. We sought to systematically compare 3D digital and physical models for medical personnel and parent education compared to traditional methods.Methods: 3D printed and digital models were made out of MRI and CT data for 20 common CHD. Fellows and nurse practitioners used these models to explore intra-cardiac pathologies following traditional teaching. The models were also used for parent education in outpatient settings after traditional education. The participants were then asked to fill out a Likert scale questionnaire to assess their understanding and satisfaction with different teaching techniques. These ratings were compared using paired t-tests and Pearson’s correlation. Results: Twenty-five medical personnel (18 fellows; 2 nurses; 4 nurse practitioners and one attending) and twenty parents participated in the study. The diagnosis varied from simple mitral valve pathology to complex single ventricle palliation. Parent and medical personnel understanding with digital models was significantly higher than traditional (p = 0.01). Subjects also felt that physical models were overall more useful than digital ones (p=0.001). Physicians using models for parent education also perceived the models to be useful, not significantly impacting their clinical workflow.Conclusions: 3D models, both digital and printed, enhance medical personnel and parental understanding of CHD.
Effect of novel coronavirus disease 2019 infection on chronic kidney disease G1-G5, G5 Dialysis and G5 Transplantation
Authors: Amiri Fateme Shamekhi
Published: August 2020

Background: The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2) is a highly infectious disease that causes lethal disease and multiorgan failure. The aim of this research is to investigate association between covid-19 infection and kidney dysfunction.Methods and materials: In this retrospective study, sixty-eight patients with kidney dysfunction and covid-19 infection were investigated. Clinical features, laboratory data at initial presentation, management and outcomes were collected.The paper has written based on searching PubMed Central and Google Scholar to identify potentially relevant articles. Median, percentage, mean ± standard deviation (SD), two-tailed t and chi-square and Cohen᾽s-d tests were used for statistical analyses. Moreover, relative risk, odds ratio, pearson᾽s correlation for statistical analyses were used. Results: The average age of patients at time of diagnosis in covid-19 nephropathy was 52.04 ± 14.42 years (ranging from 24 years to 88 years). There was not statistical significance correlation between lymphocytopenia and serum creatinine (SCr) in covid-19 nephropathy (R2=0.063; p-value= 0.33). Effect size of elevated IL-6 on decreased estimated glomerular filtration rate (eGFR) in covid-19 nephropathy was assessed 0.656 (medium effect size). Relative risk and odds ratio of acute kidney disease (AKD) in covid-19 nephropathy were assessed 0.57 and 0.4, respectively (p-value: 0.422). Correlation between SCr changes and time of emergent AKI (acute kidney injury), AKD and chronic kidney disease (CKD) was assessed with R2 of 0.0003 and p-value of 0.94 (not significant). Conclusion: The present study revealed medium effect size of elevated IL-6 on decreased eGFR. Future clinical research is required for investigating novel unknown findings in covid-19 nephropathy.
Circular RNA circANKS1B as the Sponge of miR-152-3p Promotes Prostate Cancer Progression by up-Regulating TGF-α Expression
Authors: Tao Liangjun , Pan Xinyuan , Wang Jiawei , Zhang Li , Tao Lingsong , Liang Chaozhao
Published: August 2020

Background: Growing studies indicate that circRNAs play critical roles in human diseases, and show great potential as biomarkers and therapeutic targets. This study aims to investigate the expression and function of circANKS1B in prostate cancer (PC).Methods: The expression of circANKS1B and miRNA-152-3p were determined by real-time qRT-PCR. The cell migration and invasion were measured by transwell assay. The interaction between circANKS1B and miR-152-3p was confirmed by dual-luciferase reporter gene assay. Rescue experiments were conducted to demonstrate whether circANKS1B regulated the migration and invasion of PC cells by the circANKS1B-miR-152-3p-TGF-α pathway.Results: The expression of circANKS1B was dramatically up-regulated both in PC cells and tissues. Moreover, high circANKS1B expression was associated with a poor prognosis of PC patients. Dual-luciferase reporter assay indicated that circABKS1B directly bound to miRNA-152-3p. Furthermore, circANKS1B negatively regulated miR-152-3p expression. Knockdown of circANKS1B remarkably suppressed PC cells invasion and TGF-α expression, while the effects of circANKS1B silencing were reversed by miR-152-3p deficiency. In addition, the impact of miR-152-3p silencing on PC cell invasion was also abrogated by TGF-α deficiency. In all, circANKS1B as the sponge of miR-152-3p promotes prostate cancer progression by up-regulating TGF-α expression.Conclusion: Our findings reveal that circANKS1B could be a potential prognostic biomarker and therapeutic target of PC.
Synovial Sarcoma on Magnetic Resonance Imaging: a Retrospective Study on Tumor Configuration and Postoperative Surveillance
Authors: Sedaghat Sam , Schmitz Frederick , Berek Johannes , Borchers Charlotte , Sedaghat Maya
Published: August 2020

Background: To assess the configuration of primary and recurrent synovial sarcoma on MRI. Additionally, to evaluate postoperative MRI regarding diagnostic performance and locoregional post-treatment changes.Methods: Twenty-five patients with histologically proven synovial sarcomas underwent 1.5-T MRI follow-up between 2012 and 2018. In all, 258 pre- and postoperative MRIs with available radiological and pathological were screened for primary/recurrent synovial sarcoma, diagnostic performance (false-positive/-negative and true-positive/-negative values) and post-treatment changes.Results: The median age of the patients was 40±15.2 years. The median volumes of primary and recurrent synovial sarcomas were 603 cm3 and 806 cm3, respectively. Of the patients 24% presented recurrences (n=6). In two patients false-positive diagnosis was made . There was one false-negative diagnosis of synovial sarcoma. Primary synovial sarcomas were significantly most often polycyclic/multilobulated (p=0.01) and heterogeneous in appearance with marked contrast enhancement. Recurrent synovial sarcomas showed two appearances: ovoid/nodular/homogeneous and polycyclic/multilobulated/heterogeneous, both with marked contrast enhancement. The most common post-treatment changes were subcutaneous (92%; p<0.001) and muscular edema (72%; p<0.001-0.003). Conclusion: While the configuration of primary synovial sarcomas was mainly polycyclic/multilobulated/heterogeneous, recurrent synovial sarcomas showed two shapes: ovoid/homogeneous and polycyclic/multilobulated/heterogeneous. MRI is still a highly valuable imaging modality for the postoperative surveillance of synovial sarcomas. Subcutaneous and muscular edema are common post-treatment changes.
Privacidad y seguridad en la nube: algunas implicaciones jurídico-económicas desde el comercio electrónico transfronterizo
Authors: Stella Rodríguez Gladys
Published: August 2020

Hoy la sociedad del conocimiento demanda una tecnología avanzada. Por ello todo país y organización empresarial que desee ser desarrollada y competitiva ha de incorporar soluciones digitales disruptivas, como servicios completos basados en datos y soluciones de plataforma integrada, centrándose en generar ingresos digitales adicionales y optimizar la interacción y el acceso del cliente. Precisamente en este ecosistema digital único se desarrolla la contratación de servicios en la nube. Aunque son varios los beneficios, también son diversos los retos, uno de los principales en este modelo de acuerdo digital denominado cloud computing o computación en la nube, es la privacidad y seguridad de la información que se maneja. De manera que se expondrá primeramente la naturaleza de este modelo comercial digital, seguidamente se describen las obligaciones y responsabilidades de las partes contratantes; igualmente se destaca la postura de algunos proveedores de este servicio cloud en materia de privacidad y seguridad, ofreciéndose algunas alternativas de contratación para delimitar la responsabilidad de los participantes. De igual forma, se explican algunos aspectos sobre seguridad jurídica en estos contratos; se analizan algunos modelos de acuerdos preferenciales internacionales sobre protección de datos en el ámbito del comercio digital propio de la nube. Finalmente se desatacan los desafíos de América Latina frente a la computación en la nube. Se desarrolla una investigación no experimental de carácter descriptivo, basada en el análisis de contenidos emanados por autores y organismos especializados en TIC, así como se abordan los documentos de la OMC, CNUDMI y CEPAL.
Algunas reflexiones sobre la jurisdicción castrense peruana
Authors: Giles Ferrer Arturo Antonio
Published: August 2020

Se plantea líneas de investigación de lo que se entiende debiera ser el trabajo intelectual, en justicia militar para los próximos años, en la inteligencia de consolidarla académicamente, en orden a construir una concepción peruana exportable de dicha jurisdicción especial, teniendo en cuenta además sus particularidades, que se originan en su ubicación entre los sistemas de justicia y defensa nacional así como en la Historia del Perú.
Era of Efficiency: New teaching models in a self-directed learning environment (Preprint)
Authors: Raphael Kirsten , Novintan Shonnelly , Foran Daniel , Campioni-Norman Daniel
Published: August 2020

UNSTRUCTURED

During the COVID-19 lockdown, medical schools in the United Kingdom withdrew their students from clinical placements and delivered education and examinations via online platforms. The logistical difficulty of timetabling a multitude of clinicians, with many working busier rotas on the front lines, to give one-hour lectures delayed the delivery of medical education. During this delay, the United Hospitals (UH) Medgroup set up an online platform called TeachtoLondon that recruited doctors and senior students to deliver 10-minute tutorials. Even with medical school teaching having resumed, TeachtoLondon remains popular due to its efficient and bespoke model. The short tutorials made the content more accessible and, more importantly, more useful as a revision tool. Compared to a one-hour online lecture that lacks ‘virtual bookmarks’, a playlist of tutorials allows easy navigation for students to revisit difficult topics, a pivotal part of learning. Teachtolondon is also popular with tutors, as it facilitates participation in teaching despite reduced availability due to COVID redeployment. It also allowed recruitment of doctors internationally, who would have been prevented by time zone differences from giving live lectures. Lastly, the UH network allowed students from any of the London medical schools to request a tutorial topic. Topics were allocated to the large database of tutors, providing an efficient turnaround, which is flexibility that a medical school’s rigid curriculum does not allow. The TeachtoLondon project could be adapted as an effective teaching model that promotes digestible, bite-sized learning and provides uniform teaching to students, whilst simultaneously acting as a revision tool.
Very severe hypertriglyceridemia in a subject with poor glycemic control: a case report with general consideration
Authors: Xhardo E. , Agaçi F.
Published: August 2020

Hypertriglyceridemia is defined as a value of fasting serum triglyceride over 150 mg/dl. The classification of hypertriglyceridemia according to the Endocrine Society includes mild and moderate hypertriglyceridemia, severe hypertriglyceridemia and very severe hypertriglyceridemia. Mild and moderate hypertriglyceridemia increases the risk for cardiovascular events while severe and very severe hypertriglyceridemia is a risk factor for acute pancreatitis. Conventional pharmacological therapy of hypertriglyceridemia includes fibrates, niacin, statins, ezetimibe, and omega-3 fatty acid. Other triglyceride-lowering therapies are represented by plasmapheresis and lipoprotein lipase gene therapy. The present work refers to a 55-year-old man without a history of family diabetes mellitus (DM), dyslipidemia, premature coronary artery disease, diagnosed with type 2 DM in 2016, from 2018 on insulin treatment; he was hospitalized for endocrine evaluation. The patient had a history of high blood pressure for approximately 15 years, chronic kidney disease, very severe hypertriglyceridemia, and chronic obstructive pulmonary disease. The patient followed treatment with hypoglycemic, hypolipemic, low-salt diet, fibrates, statins, omega-3 fatty acid.
Менеджмент пациента с тиреотоксикозом: реальная клиническая практика
Authors: Kuprinenko N.
Published: August 2020

No abstract
Молекулярно-генетические исследования в диагностике дифференцированного тиреоидного рака: обзор литературы
Authors: Nechay O.P. , Kvitka D.M. , Lishchynsky P.O. , Mazur O.V. , Palamarchuk V.O.
Published: August 2020

Дооперационная диагностика дифференцированного рака щитовидной железы (ДРЩЖ) остается актуальной проблемой. При цитологической оценке тиреоидных узлов в 5–20 % случаев невозможно четко разграничить доброкачественную и злокачественную патологию, что особенно актуально при категории Bethesda III и IV. Чтобы не пропустить рак и дифференцировать процесс, в 50–70 % случаев все еще проводят диагностические геми-/тиреоидэктомии с лимфодиссекцией. Операция несет определенные финансовые затраты и потенциальный риск для больного. С целью оптимизации диагностики ДРЩЖ в последние годы в клинической практике используются методы молекулярно-генетического анализа. Данный метод позволяет выявлять пациентов с повышенным риском онко­образования и прогнозировать качество и активность процесса, в случае необходимости определить объем оперативного вмешательства — от гемитиреоидэктомии в случае микрокарциномы с благоприятным прогнозом до — в противном случае — тиреоидэктомии с лимфаденэктомией. Понимание процессов онкогенеза тиреоидных опухолей с использованием молекулярно-генетического тестирования позволяет врачу аргументированно предоставить пациенту информацию о возможном наличии ДРЩЖ, его форме, агрессивности, возможном наследственном характере, снижает количество диагностических хирургических вмешательств при сомнительном результате цитологии (до 69 %). Учитывая большой объем накопленной информации о разновидностях мутаций тиреоидных узлов, в ближайшее время следует ожидать математического компьютерного моделирования стратификации риска выявления ДРЩЖ, его агрессивности и дальнейшей персонализированной терапии больного.
Deteksi Spoofing Wajah Menggunakan Faster R-CNN dengan Arsitektur Resnet50 pada Video
Authors: Sunario Megawan  , Wulan Sri Lestari
Published: August 2020

Deteksi wajah merupakan proses mendasar dan penting dalam bidang pengenalan wajah yang sudah diteliti secara luas. Tujuan deteksi wajah adalah menentukan keberadaan dan menandai posisi wajah, baik pada gambar maupun video, yang disebut dengan bounding box. Salah satu masalah penting dalam deteksi wajah adalah membedakan wajah spoof dan non-spoof yang disebut sebagai deteksi spoofing wajah. Deteksi spoofing wajah merupakan pekerjaan penting yang digunakan untuk menjamin keamanan otentikasi berbasis wajah dan sistem analisis wajah. Oleh karena itu, dibutuhkan sebuah model yang dapat mendeteksi spoofing wajah. Pada makalah ini dilakukan proses membangun model yang dapat digunakan untuk mendeteksi wajah spoof dan non-spoof pada video menggunakan algoritme Faster R-CNN dengan arsitektur Resnet50. Faster R-CNN merupakan salah satu algoritme yang unggul dalam menyelesaikan berbagai persoalan deteksi objek. Dataset yang digunakan adalah Replay-Attack Database yang disediakan oleh Idiap Dataset Distribution Portal. Pada tahap training digunakan 360 video spoof dan non-spoof. Rata-rata nilai akurasi yang dihasilkan pada tahap training adalah 97,07%, dengan jumlah epoch sebanyak 21. Hasil pengujian menunjukkan bahwa model yang dihasilkan berhasil menentukan bounding box dengan akurat dan mendeteksi spoof dan non-spoof wajah pada video dengan efektif.
Analisis Epitope Sel T pada SARS-Cov2 dengan Pendekatan Bioinformatika
Authors: Miftahurrahma Rosyda  , Faisal Fajri Rahani
Published: August 2020

Pada awal tahun 2020 dunia digemparkan dengan tersebarnya wabah secara global yang menyerang pernapasan seperti wabah SARS pada tahun 2003, yaitu COVID-19. Virus penyebab wabah yang bernama SARS-Cov2 ini ternyata memiliki kemiripan ~87.5% dengan SARS-Cov. Kemiripan ini dapat digunakan untuk mengembangkan obat dan vaksin yang sesuai dengan virus yang sekarang. Dalam hal ini, pendekatan secara bioinformatika dapat dilakukan sebagai tahap awal pengembangan vaksin. Salah satu cara pengembangan vaksin adalah vaksin berbasis epitope. Data biologi yang tersedia dan diserahkan kepada publik terkait epitope Sel T dan sekuen protein pada virus dapat diolah dengan beberapa tool bioinformatika yang tersedia secara online. Makalah ini membandingkan perhitungan karakter physicochemical antara epitope SARS-Cov dan sekuen protein SARS-Cov2 pada lokasi yang sama. Karakter yang dibandingkan yaitu berat molekuler, titik isoelectric, indeks alifatik, GRAVY, indeks kestabilan, dan antigenisitas. Pengolahan data dilakukan dengan matriks korelasi. Dari hasil pengolahan tersebut diketahui bahwa karakter physicochemical antara SARS-Cov dan SARS-Cov2 memiliki hubungan yang kuat.
Pengaruh Komposisi Media Tanam terhadap Pertumbuhan Bibit Asam Jawa dan Asam Manis (Tamarindus indica L.)
Authors: Puspasari Aisyah , Rogomulyo Rohlan , Indradewa Didik
Published: August 2020

Tanaman asam merupakan tanaman penting yang mempunyai potensi, tetapi kurang diperhatikan. Tanaman asam mempunyai manfaat sebagai rempah dan jamu tradisional. Tidak ada penelitian mengenai bagaimana komposisi media tanam yang baik untuk asam jawa dan asam manis. Atas dasar tersebut dilakukan penelitian “Pengaruh Komposisi Media Tanam terhadap Pertumbuhan Bibit Asam Jawa dan Asam Manis (Tamarindus indica L.)”. Tujuan penelitian ini adalah mempelajari pengaruh komposisi media tanam terhadap pertumbuhan bibit asam jawa dan asam manis. Penelitian ini telah dilaksanakan pada bulan Agustus 2017 sampai Desember 2017 di Pusat Inovasi Agroteknologi Universitas Gadjah Mada, Berbah, Yogyakarta. Penelitian ini menggunakan RAKL (Rancangan Acak Kelompok Lengkap) faktorial 4 x 2 dan tiga blok sebagai ulangan. Faktor pertama komposisi media  tanam  antara  tanah : pupuk kandang : arang sekam 4 : 0 : 0, tanah : pupuk kandang : arang sekam 2 : 1 : 1, tanah : pupuk kandang : arang sekam 1 : 2 : 1, tanah : pupuk kandang : arang sekam 1 : 1 : 2. Faktor kedua jenis asam antara: asam jawa dan asam manis. Data hasil pengamatan dianalisis varians pada tingkat keprcayaan 95%. Apabila terdapat beda nyata antar perlakuan, diuji lanjut dengan DMRT (Duncan Multiple Range Test). Hasil yang diperoleh tidak terdapat pengaruh kombinasi perlakuan media  tanam terhadap pertumbuhan bibit asam jawa dan asam manis.
Seleksi Jagung Manis (Zea mays L. var. saccharata) Hibrida Berdasarkan Umur, Komponen Hasil, dan Kadar Gula Pasca Panen
Authors: Andiman Andiman , Murti Rudi Hari
Published: August 2020

Pengembangan kultivar hibrida jagung manis masih dibutuhkan karena permintaan masih tetap tinggi. Kultivar superior mempunyai umur panen yang cepat, hasil tinggi dan kandungan gula tinggi. Program pemuliaan pada jagung manis masih terus dikembangkan. Salah satu caranya yaitu menciptakan varietas unggul. Varietas unggul merupakan varietas yang memiliki potensi daya hasil yang tinggi. Penelitian ini bertujuan untuk memperoleh genotipe F1 yang memiliki sifat unggul, yaitu berumur genjah, berproduksi tinggi, dan memiliki tingkat kemanisan tinggi. Penelitian ini dilakukan di lahan persawahan di Desa Bopongan jalan Imogiri Barat KM 5, Bantul, Yogyakarta. Bahan yang digunakan dalam penelitian ini adalah FSB × 24-8, 38 × 40, 24-8 × FMB, FM × 15-1, FM × 24-8, 24-8 × 24-4, FM × 22-3, 1 × 31, 75 × 13, 42-4 × 24-8, A × C, A × H, B × A, B × R, C × B, C × S,  R × C, R × T, T × H, dan T × K sebagai hasil persilangan, sedangkan Talenta sebagai kultivar pembanding. Hasil penelitian ini didapatkan jagung manis hibrida yang berumur genjah adalah hibrida FM × 15-1, FM × 22-3, 1 × 31, A × C, A × H, B × A, B × R, R × C, dan T × H. Jagung manis hibrida yang memiliki sifat unggul lainnya adalah hibrida T × K (karakter bobot tongkol per tanaman, bobot tongkol, dan diameter tongkol kulit tengah), B × R (karakter jumlah tongkol), 24-8 × FMB (karakter panjang tongkol kulit), FM × 24-8 (karakter jumlah baris per tongkol), dan FM × 22-3 (karakter kadar gula pasca panen digital).
Pengaruh Umur Bibit terhadap Pertumbuhan dan Hasil Pakcoy (Brassica rapa ssp. chinensis) pada Hidroponik NFT
Authors: Santoso Arik , Widyawati Nugraheni
Published: August 2020

Pakcoy (Brassica rapa ssp. chinensis) merupakan jenis sayuran yang memiliki banyak manfaat bagi tubuh manusia. Dalam budidaya pakcoy secara hidroponik NFT umur bibit adalah salah satu aspek penentu dalam peningkatan produktivitas. Penelitian ini bertujuan untuk mengetahui pengaruh umur bibit terhadap pertumbuhan dan hasil sawi pakcoy dan menentukan umur bibit yang memberikan hasil tertinggi sawi pakcoy dengan budidaya hidroponik NFT. Percobaan menggunakan Rancangan Acak Kelompok (RAK) faktor tunggal terdiri atas lima variasi umur bibit dengan ulangan sebanyak lima kali. Umur bibit yang diuji adalah 0 HSS, 5 HSS, 10 HSS, 15 HSS dan 20 HSS. Pengamatan pertumbuhan tanaman sawi meliputi tinggi tanaman, jumlah daun, luas daun, bobot segar tanaman, bobot kering tanaman dan klorofil. Komponen hasil yang diamati yaitu bobot segar tajuk. Data yang diperoleh dianalisis menggunakan Sidik Ragam (ANOVA) taraf 5%, dilanjutkan dengan uji Beda Nyata Jujur taraf 5% dan analisis korelasi. Hasil penelitian menunjukkan bahwa umur bibit berpengaruh terhadap pertumbuhan dan hasil sawi pakcoy. Pada budidaya sawi pakcoy secara hidroponik sistem NFT hasil tertinggi diperoleh jika ditanam langsung dari bibit 0 HSS atau menggunakan bibit berumur 5 HSS. Penggunaan umur bibit yang tepat dalam budidaya pakcoy secara hidroponik NFT dapat mendukung pertumbuhan dan hasil yang optimal pada akhir masa panennya.
MODELING THE DYNAMICS OF THE TUMOR DEVELOPMENT PROCESS
Authors:   VLADIMIR VLADIMIROVICH SELVINSKY  Amur State University, SELVINSKY VLADIMIR VLADIMIROVICH
Published: August 2020

This article discusses the well-known mathematical model of American scientists Rescigno and De Lisi, describing the growth of a tumor of a living organism. The model is a multivariable system of ordinary differential equations with respect to variables characterizing tumor cell and lymphocyte populations. On the basis of the mathematical package of MathCad, a detailed study of various options for the possible development of the tumor is carried out.
DEVELOPING A FRAMEWORK FOR CREATING USER INTERFACE VBA MACROS
Authors:   ANNA SERGEEVNA GERMAN Amur State University, GERMAN ANNA SERGEEVNA , VESELOVA ELENA MIKHAILOVNA ,   ELENA MIKHAILOVNA VESELOVA Amur State University
Published: August 2020

The article is devoted to the problem of creating graphical user interfaces in the VBA development environment. The main requirements for the development of user interfaces are formulated, taking into account the specifics of using interfaces in VBA programs. The prototype of an application framework for creating user interfaces is made, which should save developers time.
The Cultural Populism of Iosif I. Kablits (Yuzov) and its Foundations
Authors: Mokshin Gennadiy N.
Published: August 2020

This article reconstructs the cultural doctrine of the famous publicist of populism (narodnichestvo), I.I. Kablits (Yuzov). To just equate Kablits views with the slogan of yuzovshchina would be a narrow interpretation of his kul'turnichestvo; the slogan is characteristic for extreme right-wing populism during the upsurge of the revolutionary populist movement (narodovol'cheskoe dvizhenie). In 1880, Kablits was the first of the legal populists to pose the question, What is populism? According to the publicist, true narodnichestvo should be based on the principle that the forms of public life of the people must be in conformity with the development level of their consciousness. The author explains Kablits evolution from Bakunism to a peasant-centered narodnichestvo by his interpretation of the reasons for the split between the intelligentsia and the people. Kablits considered them antagonists, and defined the ultimate goal of the narodniki as the liberation of the people from the power of the intellectualbureaucratic minority, the latter supposedly trying to subjugate the life of the masses to its will. The article analyzes the main provisions of Kablits sociocultural concept of social transformations: apolitism, populism, and the initiative of the masses. The article identifies the differences between his program of developing the cultural identity of the people, on the one hand, and other populists' understanding of the tasks of cultural work, on the other. Particular attention is paid to Kablits-Yuzov's attitude towards the problem of educating the masses. Kablits was one of the few Russian populists who opposed the idea that the foundations of the worldview of the people must be changed, arguing that this would eliminate the traditional moral values of the village, including the sense of collectivism. The author assesses how Kablits, the leading publicist of the newspaper Nedelya, contributed to the establishment of a cultural direction in narodnichestvo at the turn of the 1870s and 1880s. According to the author, Kablits played a leading role in shaping the ideology of the right flank of the cultural direction in narodnichestvo. However, the pure populism of Kablits turned out to be too pseudo-scientific, dogmatic and irrational to attract the democratic intelligentsia for a long time; the latter had already become disillusioned with the idea of the people as the creator of new forms of social life.
The Humanitarian Aspect of China-Russia Relations as an Important Component of Strategic Partnership
Authors: Yuyao Wu
Published: August 2020

The article is devoted to Sino-Russian humanitarian cooperation at the beginning of the 21st century. Currently, the two countries are jointly restructuring both the regional subsystem and the global system of international relations. In this regard, the question of how the neighbors build bilateral ties, characterized as a "strategic partnership", is becoming increasingly relevant. China and Russia are strengthening their bilateral relations, which enables them to coordinate their actions more confidently and realize their national interests both regionally and globally. This article examines the role that the humanitarian aspect plays in contemporary Sino-Russian relations. To this end, the author has analyzed the humanitarian component of the countries foreign policy at the political and conceptual level. Wu also studied the organizational mechanism as well as the content of bilateral relations in the humanitarian sphere since 2001. At the same time, the author considered the attention paid to this aspect of diplomacy both at the political level as well as by non-government analysts, while stressing their branch structure. The article concludes that the humanitarian aspect is important because it is an integral part of bilateral relations that promises to help advance national interests.
On Embedding of the Morse-Smale Diffeomorphisms in a Topological Flow
Authors: Grines V. Z. , Gurevich E. Ya. , Pochinka O. V.
Published: August 2020

This review presents the results of recent years on solving of the Palis problem on finding necessary and sufficient conditions for the embedding of Morse-Smale cascades in topological flows. To date, the problem has been solved by Palis for Morse-Smale diffeomorphisms given on manifolds of dimension two. The result for the circle is a trivial exercise. In dimensions three and higher new effects arise related to the possibility of wild embeddings of closures of invariant manifolds of saddle periodic points that leads to additional obstacles for Morse-Smale diffeomorphisms to embed in topological flows. The progress achieved in solving of Paliss problem in dimension three is associated with the recently obtained complete topological classification of Morse-Smale diffeomorphisms on three-dimensional manifolds and the introduction of new invariants describing the embedding of separatrices of saddle periodic points in a supporting manifold. The transition to a higher dimension requires the latest results from the topology of manifolds. The necessary topological information, which plays key roles in the proofs, is also presented in the survey.
On Spectral and Evolutional Problems Generated by a Sesquilinear Form
Authors: Yakubova A. R.
Published: August 2020

On the base of boundary-value, spectral and initial-boundary value problems studied earlier for the case of single domain, we consider corresponding problems generated by sesquilinear form for two domains. Arising operator pencils with corresponding operator coefficients acting in a Hilbert space and depending on two parameters are studied in detail. In the perturbed and unperturbed cases, we consider two situations when one of the parameters is spectral and the other is fixed. In this paper, we use the superposition principle that allow us to present the solution of the original problem as a sum of solutions of auxiliary boundary-value problems containing inhomogeneity either in the equation or in one of the boundary conditions. The necessary and sufficient conditions for the correct solvability of boundary-value problems on given time interval are obtained. The theorems on properties of the spectrum and on the completeness and basicity of the system of root elements are proved.
English in Germany: Evidence from domains of use and attitudes
Authors: Davydova Julia Gennad'evna
Published: August 2020

This paper discusses the changing role of English in Germany drawing on evidence from domains of English use and speakers attitudes. In so doing, it reports two case studies carried out at the University of Mannheim, Germany. The quantitative data and its methods of evaluation are discussed in the sections reporting case studies. The first study documents the use of English across formal and informal settings as well as in spontaneous interactions. In so doing, it reports the results of a survey collected from 172 students. The second study discusses the results of a survey tapping into German speakers attitudes towards two native (British, American) and two non-native (Indian, German) Englishes, thereby eliciting respondents attitudinal orientations towards English varieties including their own. This case study is based on data stemming from 94 students. The first case study shows that English in Germany has been continuously expanding its social domains of use and there is a small but stable minority of German speakers using English in spontaneous daily interactions. The second case study highlights the importance of the native-speaker model for the attitudinal mindset of the German learners; they see no value in speaking German English and clearly do not identify with this linguistic variety, a finding which reveals their exonormative orientation. Against this backdrop, I conclude that whereas English spoken in Germany shows clear signs of evolving into an ESL variety, it is still, by and large, an EFL English, at least in terms of attitudinal orientations professed by educated young adults.
لجيل الألفية (Arab Fun Easy Learn) تطبيق لتعلم اللغة العربية المتفاعلة والمناسبة
Authors: Faizul walida Ismani Ahmad , Mahliatussikah Hanik
Published: August 2020

في زماننا الحاضر كثير من الإنسان يرغبون في استخدام الجهاز والتسهيلات الإيلكترونية.كذلك في عملية التعليم والتعلم، لا بد علينا أن نتبع نمو الزمان كـأن لا نكون المجتمع المتخلف. تعليم وتعلم اللغة العربية حاجة إلى الرنامج الفعال لتسهيل تلك العملية. هناك التبيق الذي يسهل من يريد أن يتعلم اللغة العربية بشكل مستقل ويناسب لكل المرحلة العمرية. في هذا التطبيق  تقديم المفردات أي الجلمة أو التعبيرات بشكل السمعي البصري وكذلك التدريبات المتنوعة لتأكيد المفردات التي قد تم تقديم من قبل.
Aceh Besar 7 لترقية قدرة الطلبة على فهم تركيب الجمل المفيدة بالمدرسة المتوسطة Power Point تطبيق طريقة المعدلة بوسيلة
Authors: Dhifa Maisuratud , Qusaiyen Qusaiyen , Ninoersy Tarmizi
Published: August 2020

In this study, the researcher observed thatteachersin MTsN 7 Aceh Besar do not use a special method andinterestingmeans in teaching Arabic, but rather fixate on the memorization of textsand listen to the students’ memorization in class. Therefore, students find it difficult to learn Arabic and eventually find the lesson a burden. They can not express their ideas directly and end up with losing interest in the study. They lack enthusiasm and have no strong motivation to enrich and apply the vocabulary and express their knowledge of Arabic. One of the reasons for this problem is that teachers do not use an attractive tool during the learning process. As an effort to overcome these problems, the researcher uses the Snowball Throwing method to improve students' understanding, especially on the lesson about grammer. The purpose of this study is to identify the influence and response of students of MTsN 7 in learning the lesson about Grammer by using Mu’addalah method. The research method used by the researcher is pre-experiment with pre-test and post-test design in one group design, and to collect the data,the researcher uses questionnaire and test. The approach used by the researcher is quantitative. As the population of this study are all students in MTsN 7, students in the second grade are selected as the sample, which is amounted to 28 students. The result is obtained from T-test Sig (.05<.001). This shows that the hypothesis is zero (ho) is rejected and hypothesis (Ha) is accepted, it is evident that the usage of Mu’addalah method is influential to improve student’s understanding about Grammer lesson.