bluuebunny/crossref_metadata_2025 huggingface dataset:
Appointment Scheduling Under Patient Preference and No-Show Behavior
Authors: Feldman Jacob , Liu Nan , Topaloglu Huseyin , Ziya Serhan
Published: June 2014

Motivated by the rising popularity of electronic appointment booking systems, we develop appointment scheduling models that take into account the patient preferences regarding when they would like to be seen. The service provider dynamically decides which appointment days to make available for the patients. Patients arriving with appointment requests may choose one of the days offered to them or leave without an appointment. Patients with scheduled appointments may cancel or not show up for the service. The service provider collects a “revenue” from each patient who shows up and incurs a “service cost” that depends on the number of scheduled appointments. The objective is to maximize the expected net “profit” per day. We begin by developing a static model that does not consider the current state of the scheduled appointments. We give a characterization of the optimal policy under the static model and bound its optimality gap. Building on the static model, we develop a dynamic model that considers the current state of the scheduled appointments, and we propose a heuristic solution procedure. In our computational experiments, we test the performance of our models under the patient preferences estimated through a discrete choice experiment that we conduct in a large community health center. Our computational experiments reveal that the policies we propose perform well under a variety of conditions.
Thou shalt not varus: still applicable in total knee arthroplasty?
Authors: Waterson H. B. , Philips J. R. A. , Mandalia V. I. , Toms A. D.
Published: June 2014

Mechanical alignment has been a fundamental tenet of total knee arthroplasty (TKA) since modern knee replacement surgery was developed in the 1970s. The objective of mechanical alignment was to infer the greatest biomechanical advantage to the implant to prevent early loosening and failure. Over the last 40 years a great deal of innovation in TKA technology has been focusing on how to more accurately achieve mechanical alignment. Recently the concept of mechanical alignment has been challenged, and other alignment philosophies are being explored with the intention of trying to improve patient outcomes following TKA.

This article examines the evolution of the mechanical alignment concept and whether there are any viable alternatives.
Characterization of a Novel Recombinant Hyaluronan Binding Protein for Tissue Hyaluronan Detection
Authors: Jadin Laurence , Huang Lei , Wei Ge , Zhao Qiping , Gelb Arnold B. , Frost Gregory I. , Jiang Ping , Shepard H. Michael
Published: June 2014

Tumor necrosis factor-Stimulated Gene 6 protein (TSG-6) is a hyaluronan (HA)-binding glycoprotein containing an HA-binding Link module. Because of its well-defined structure, HA binding properties and small size, TSG-6 is an excellent candidate as an alternative to animal-derived HA-binding protein (HABP) for the detection of HA. The present work describes the generation and characterization of a novel recombinant HA-binding probe obtained by fusion of a modified TSG-6 Link module with mutationally inactivated heparin-binding sequence and the Fc portion of human IgG1 (TSG-6-ΔHep-Fc) for tissue HA detection in histological samples. Direct binding assays indicated strong binding of TSG-6-ΔHep-Fc to HA, with little residual binding to heparin. Histolocalization of HA in formalin-fixed, paraffin-embedded tissue sections using biotin-TSG-6-ΔHep-Fc resulted in hyaluronidase-sensitive staining patterns similar to those obtained with biotin-HABP, but with improved sensitivity. HA was detected in many human tissues, and was most abundant in soft connective tissues such as the skin dermis and the stroma of various glands. Digital image analysis revealed a linear correlation between biotin-HABP and biotin-TSG-6-ΔHep-Fc staining intensity in a subset of normal and malignant human tissues. These results demonstrate that TSG-6-ΔHep-Fc is a sensitive and specific probe for the detection of HA by histological methods.
Attachment of β-Cyclodextrins on Cotton and Influence of β-Cyclodextrin on Ester Formation with BTCA on Cotton
Authors: Bhaskara Usha Rashmi , Tourrette Audrey , Jocic Dragan , Warmoeskerken M. M. C. G.
Published: June 2014

Cotton was treated with β-cyclodextrin (BCD) and two derivatives of β-cyclodextrin (2-hydroxypropyl-β-cyclodextrin and monochlorotriazinyl-β-cyclodextrin) to assess the optimal type for fixation with cotton. The experimental results showed that treatment of cotton with BCD using the crosslinker BTCA resulted in higher fixation than the treatments with the other two derivatives. The concentration of BTCA used did not significantly influence the amount of fixation of BCD on cotton. FTIR-ATR spectroscopic analysis showed that the amount of ester formed on the fabric was influenced by the addition of BCD on cotton with BTCA in comparison to crosslinking of only BTCA with cotton. The laundering tests showed relatively poor washfastness of the β-cyclodextrins on the fabrics.
Internet versus Television Advertising: A Brand-Building Comparison
Authors: Draganska Michaela , Hartmann Wesley R. , Stanglein Gena
Published: June 2014

Many advertisers are reluctant to shift a large proportion of their advertising budgets to the Internet because they still view television advertising as the main vehicle for building a brand. Using a unique and rich data set comprising 20 campaigns across a variety of industries, this study demonstrates that Internet ads perform on par with television ads on the brand-building metrics that advertisers use and trust. The authors extend traditional brand–message recall measurements to facilitate comparisons between Internet formats and television by supplementing brand–message surveys conducted during the campaign with a set of precampaign surveys to control for preexisting brand knowledge. They find that accounting for differences in preexisting brand knowledge is paramount in obtaining valid comparisons across advertising formats because people who are exposed to Internet display ads have significantly lower levels of preexisting brand knowledge than television viewers. Without considering the differences in these “initial conditions,” television advertising seems to be more effective than advertising on the Internet, but when the preexisting differences among media formats are taken into account, the brand recall lift measures for Internet ads are statistically indistinguishable from comparable television lift measures.
En caul vaginal delivery with vasa previa diagnosed intrapartum
Authors: Groen Reinou Sybrecht , Zaharieva Maria Kirilova , McCartan Regina Marie , Johnson Clark Timothy
Published: June 2014

Background: Vasa previa is a condition fraught with severe morbidity when undiagnosed at time of delivery.

Case: A 25-year-old G4P2012 presented with preterm labor at 27 weeks. She was fully dilated and with the first push two independent vessels were coursing over the membranes; vasa previa was diagnosed. The patient pushed through two contractions to deliver a vigorous fetus en caul. The neonate did well, not requiring any blood transfusions during its neonatal stay for prematurity, and was seen for a well-child examination 4 months later, doing well.

Conclusion: The mode of delivery for a known vasa previa is a planned Cesarean section (C-section), however if vasa previa is encountered in the labor room with quick progression of the second stage an en caul delivery could be considered.
The City: A Window to Utopia?
Authors: Randviir Anti
Published: June 2014

In addressing the semiotics of utopia and the utopian, we target the semiotic techniques and principles applied in More’s seminal text Utopia (1516) that established the universal logic for utopian discourse, and raise the question of the legitimacy of describing certain cultural production as utopian. Utopian discourse is often tied with an urban context. We question this association. The semiotic interpause is hard to achieve in the context of the physical environment. Yet this is where the utopia, the city, the society, and the utopian come together. Thus it is useful to review the notion of utopia in connection with the quite practical development of the (urban) sociocultural life in which the status of objects in communicative situations is continually redefined.
Anti-inflammatory mediators for molecular imaging of atherosclerosis
Authors: Almer Gunter , Opriessnig Peter , Prassl Ruth , Mangge Harald
Published: June 2014

Nanomedicine, a young and innovative field, offers interesting approaches for diagnosis and treatment in personalized medicine. Myocardial infarction and stroke belong to the most important challenges in this context because an improved early diagnosis of individuals well before fatal clinical endpoints occur is urgently needed. The underlying cause of myocardial infarction and stroke is atherosclerosis, a chronic immune-mediated inflammation of the vascular wall involving monocytes, macrophages, T-lymphocytes, and arterial wall cells. Hence, an immense number of pro-inflammatory mediators have been investigated in the context of nanomedicine and atherosclerosis but, interestingly, only few anti-inflammatory biomarkers. Nevertheless, the anti-inflammatory axis is always present as a negative feedback if a critical inflammatory perpetuation destabilizes atherosclerotic lesions. Hence, we could show that the immune-modulating, anti-inflammatory molecules, adiponectin and interleukin-10, are useful for molecular imaging of AS plaques. Based on recent publications in animal models of atherosclerosis, we strongly assume that the inflammatory “brake” mechanisms may represent an interesting new tool to specifically target the scenario of culprit AS-lesions. In this review article we discuss the potential of adiponectin, interleukin-10 and other anti-inflammatory active molecules like targeted liposomes and high dense lipoproteins towards this.
Bilingual winks and bilingual wordplay in Montreal's linguistic landscape
Authors: Lamarre Patricia
Published: June 2014

In Québec, legislation regulates the language of public and commercial signage. As intended, this has transformed the linguistic landscape (LL) of Montreal, which looks more French than just three decades ago. But if we stop looking and actually listen to the city's soundscape, what is clear is that Montreal is a much more bilingual and multilingual city with a population increasingly able to read signs both in English and in French. Interestingly, in the Montreal LL can be found a number of commercial signs that are nothing less than wry “bilingual winks” that circumvent legislation, sometimes with quite wicked skill, and play with French and English. These bilingual winks are clearly intended for a population with the language skills to catch the wink and can be interpreted as manifestations of the increasing number of complex language repertoires, but also of a bilingual aesthetic that revels in disrupting and claiming space. It would also seem, however, that while a certain amount of covert bilingual creativity has been inspired by the legal constraints imposed in Québec, bilingual wordplay has simply found ways of creeping into the LL, despite the politics of language and legislation.
Crystal structure of 2-((E)-(6-methylpyridin-2-ylimino)methyl)-4- methylphenol, C14H14N2O
Authors: Dang Fang-Fang , Zhao Dang-Yang , Guo Hui
Published: June 2014

C14H14N2O, monoclinic, P21/n (no. 14), a = 16.0418(9) Å, b = 4.6119(2) Å, c = 17.0111(9) Å, β = 106.585(6)°, V = 1206.2 Å3, Z = 4, Rgt(F) = 0.0660, wRref(F2) = 0.1994, T = 293 K.
Crystal structure of (E)-3-(iodomethylene)-2,3-dihydro-[1,4]oxazino- [2,3,4-ij]quinolin-4-ium triodide —iodine (2:1), [C12H9INO]I3·0.5I2, C12H9I5NO
Authors: Batalov Vladimir I. , Kim Dimitri G. , Dikhtiarenko Alla , Amghouz Zakariae , Bartashevich Ekaterina V. , García-Granda Santiago
Published: June 2014

C
Plutonium sorption and precipitation in the presence of goethite at 25 and 80 ○C
Authors: Zavarin Mavrik , Zhao Pihong , Dai Zurong , Kersting Annie B.
Published: June 2014

We have examined the sorption of aqueous Pu(IV) and intrinsic Pu colloids to goethite across a Pu concentration range that spans the
solubility of Pu(IV) hydrous oxide, at 25 and 80 ℃, and after equilibration for over 100 days. The strong affinity of
aqueous Pu(IV) for the goethite surface is explained by the epitaxial growth of bcc Pu4O7 nano-particles on goethite. The
3–5 nm Pu4O7 nano-particles are strictly associated with goethite, widely dispersed across the goethite
surface, and stable over the timescale of months at both 25 and 80 ℃. There is no indication that the sorbed
Pu4O7 nano-particles alter to PuO2 over time. Intrinsic Pu colloids were identified by TEM as
3–5 nm PuO2 nano-particles. They exhibit a weaker association with the goethite surface. Aggregation of
PuO2 nano-particles was observed. There is no indication that the PuO2 nano-particles, once formed, will alter to
Pu4O7 on goethite. Based on supernatant Pu concentrations, PuO2 nano-particle aggregation behavior is consistent
with Pu(IV) hydrous oxide precipitation.
More than Spirit
Authors: Schellenberg Annette
Published: June 2014

Again and again, the Priestly text emphasizes bodily issues – in addition to the reference to male and female in Gen 1,27 and the emphasis on circumcision as the sign of the covenant in Gen 17, this is demonstrated most clearly in regulations for impurity, sin, sacrifices, and rituals and in the special requirements for priests. This article maintains that this focus on bodily issues is a reflection of an understandin

Le texte sacerdotal (P) insiste toujours à nouveau sur les aspects corporels – tels l’insistance sur »mâle et femelle« en Gen. 1,27 et sur la circoncision en tant que signe de l’alliance en Gen. 17; ceci est spécialement net dans les prescriptions spéciales pour les prêtres, tout comme dans les indications concernant l’impureté, le péché, les sacrifices et les rituels. Cette étude affirme que cette insistance sur le corps est le reflet d’une conception du sacré qui implique une dimension physique – même en ce qui concerne Dieu.

Wiederholt legt der priesterschriftliche Text das Gewicht auf körperliche Aspekte – so neben dem Verweis auf »männlich und weiblich« in Gen 1,27 und der Hervorhebung der Beschneidung als Bundeszeichen in Gen 17 besonders deutlich in den speziellen Vorschriften für Priester sowie in den Aussagen zu Unreinheit, Sünde, Opfern und Ritualen. In diesem Aufsatz wird argumentiert, dass dieser Fokus auf Körperlichkeit ein Reflex auf ein Verständnis von Heiligkeit ist, das eine physische Dimension hat – auch dort, wo es um Gott geht.
Crystal structures of two anhydrous and one hydrated 7-(arylamino)-5-methyl-2-(trifluoromethyl)-[1,2,4]-triazolo-[1,5-a]pyrimidine derivatives
Authors: Boechat Núbia , Pinheiro Luiz C.S. , Pinto Angelo C. , Silva Thiago S. , Wardell James L. , Wardell Solange M.S.V.
Published: June 2014

While in both 7-(arylamino)-5-methyl-2-(trifluoromethyl)-[1,2,4]-triazolo-[1,5-a]pyrimidines,1 [1a: aryl=3,5dichlorophenyl; 1b: aryl=2,4-dichlorophenyl), the strongest intermolecular interactions are N–H···N hydrogen bonds, different acceptor atoms are involved leading to different arrangement of molecules. In the case of 1a, N2A–H2A···N4B and N2B–H2B···N3A hydrogen bonds generate tetrameric units, composed of two molecules of each of the independent molecules, Mol A and Mol B. In the case of 1b, N2A–H2A···N4B and N2B–H2B···N4A hydrogen bonds generate C12 chains of alternate molecules A and B. As well as the strong N–H···N hydrogen bonds, there are also weaker π···π, C–X···π (X=Cl, F and H) and C–H···F interactions in 1a, and π···π, C–X···π (X=H and Cl) and C–H···X (X=F and N) interactions in 1b. In {[7-(4-chlorophenylamino)-5-methyl-2-(trifluoromethyl)-[1,2,4]-triazolo-[1,5-a]pyrimidine].(H2 O)}, [1c(H

2

O)], chains, C2
2(16) of alternate molecules of 1c and water are generated from combinations of OW–HW···N and N–H···OW intermolecular hydrogen bonds: also present are π(pyrimidine)···π(chlorophenyl), C–Cl··· π(triazole) and C–F··· π(pyrimidine) interactions. Comparisons with reported [1,2,4]-triazolo-[1,5-a]pyrimidine structures clearly show variations in the N–H···N hydrogen bonding patterns and the significant influence of the type and position of substituents on the supramolecular assemblies generated.
Multiple Diseases and Polypharmacy in the Elderly: Challenges for the Internist of the Third Millennium
Authors: Nobili Alessandro , Garattini Silvio , Mannucci Pier Mannuccio
Published: June 2014

The pattern of patients admitted to internal medicine wards has dramatically changed in the last 20–30 years. Elderly people are now the most rapidly growing proportion of the patient population in the majority of Western countries, and aging seldom comes alone, often being accompanied by chronic diseases, comorbidity, disability, frailty, and social isolation. Multiple diseases and multimorbidity inevitably lead to the use of multiple drugs, a condition known as polypharmacy. Over the last 20–30 years, problems related to aging, multimorbidity, and polypharmacy have become a prominent issue in global healthcare. This review discusses how internists might tackle these new challenges of the aging population. They are called to play a primary role in promoting a new, integrated, and comprehensive approach to the care of elderly people, which should incorporate age-related issues into routine clinical practice and decisions. The development of new approaches in the frame of undergraduate and postgraduate training and of clinical research is essential to improve and implement suitable strategies meant to evaluate and manage frail elderly patients with chronic diseases, comorbidity, and polypharmacy.
Chronic Obstructive Pulmonary Disease: A Complex Comorbidity of Lung Cancer
Authors: Grose Derek , Milroy Robert
Published: June 2014

Chronic obstructive pulmonary disease (COPD) is a major burden throughout the world. It is associated with a significantly increased incidence of lung cancer and may influence treatment options and outcome. Impaired lung function confirming COPD is an independent risk factor for lung cancer. Oxidative stress and inflammation may be a key link between COPD and lung cancer, with numerous molecular markers being analysed to attempt to understand the pathway of lung cancer development. COPD negatively influences the ability to deliver radical treatment options, so attempts must be made to look for alternative methods of treating lung cancer, while aiming to manage the underlying COPD. Detailed assessment and management plans utilising the multidisciplinary team must be made for all lung cancer patients with COPD to provide the best care possible.
The HHS Strategic Framework on Multiple Chronic Conditions: Genesis and Focus on Research
Authors: Parekh Anand K. , Goodman Richard A.
Published: June 2014

Among the 21st century's major emerging health issues, one of the most critical is the increasing prevalence of individuals with comorbidities, or multiple chronic conditions (MCCs), and the myriad challenges this poses for public health, healthcare, social services, and other sectors. Given the increasing prevalence of individuals with MCCs and the paramount role of MCCs as a healthcare cost driver, in 2008 the U.S. Department of Health and Human Services (HHS) launched an initiative to strengthen efforts by the HHS to address the effects of MCCs on health status, quality of life, and cost. In this paper, we first provide an overview of the HHS initiative with a particular focus on the approach used in developing the initiative's centerpiece, the HHS Strategic Framework on Multiple Chronic Conditions; we next describe progress in implementing one of the framework's four major goal areas (Goal 4) on facilitating research to fill knowledge gaps about, and interventions and systems to benefit, individuals with MCCs; and we conclude by suggesting additional potential priorities for research on MCCs. Although considerable research on MCCs has been reported over the past decade, the HHS Strategic Framework's goal on research provides a set of priority areas and a plan for systematically strengthening the evidence and information foundation necessary to address the challenges of MCCs in the USA. More broadly, the Strategic Framework provides a roadmap to help improve coordination between HHS operating divisions and enhance collaboration with external stakeholders to improve the quality of life for those with MCCs.
Disparities in Multiple Chronic Conditions within Populations
Authors: Shadmi Efrat
Published: June 2014

Disadvantaged populations are disproportionately affected by multiple chronic conditions (MCCs), yet few studies examine the prevalence, outcomes, or effectiveness of MCC interventions in minority and socioeconomically deprived individuals and populations. An important first step in understanding MCCs, not only in such diverse population groups, but also in the general population as a whole, is to broaden the definition and scope of MCC measurement, to encompass more than the simple additive effect of clinical conditions, and to include a wide range of health and health-related aspects that interact and make up the full spectrum of multimorbidity. Only with the use of a comprehensive MCC measurement can some of the differences between the disadvantaged populations be adequately detected. Better understanding of the disparities in access to high quality health and healthcare for persons with MCCs can help guide policy and practice aimed at the prevention and amelioration of the effects of MCCs among disadvantaged groups. Indeed, disparity in MCC populations has been identified as a key goal of the U.S. Department of Health and Human Services’ Strategic Framework on MCCs. The aim of the present paper is to describe current knowledge on disparities in the population of persons with MCCs and to guide efforts for the prevention and management of MCCs in disadvantaged populations.
Epidemiology of Multiple Chronic Conditions: An International Perspective
Authors: Schellevis François G.
Published: June 2014

The epidemiology of multimorbidity, or multiple chronic conditions (MCCs), is one of the research priority areas of the U.S. Department of Health and Human Services (HHS) by its Strategic Framework on MCCs. A conceptual model addressing methodological issues leading to a valid measurement of the prevalence rates of MCCs has been developed and applied in descriptive epidemiological studies. Comparing these results with those from prevalence studies performed earlier and in other countries is hampered by methodological limitations. Therefore, this paper aims to put the size and patterns of MCCs in the USA, as established within the HHS Strategic Framework on MCCs, in perspective of the findings on the prevalence of MCCs in other countries. General common trends can be observed: increasing prevalence rates with increasing age, and multimorbidity being the rule rather than the exception at old age. Most frequent combinations of chronic diseases include the most frequently occurring single chronic diseases. New descriptive epidemiological studies will probably not provide new results; therefore, future descriptive studies should focus on the prevalence rates of MCCs in subpopulations, statistical clustering of chronic conditions, and the development of the prevalence rates of MCCs over time. The finding of common trends also indicates the necessary transition to a next phase of MCC research, addressing the quality of care of patients with MCCs from an organizational perspective and with respect to the content of care.
Increasing Clinical, Community, and Patient-Centered Health Research for Preventing and Managing Multimorbidity
Authors: Valderas Jose M.
Published: June 2014

The report “Multiple Chronic Conditions: A Strategic Framework,” which was developed by the U.S. Department of Health & Human Services (HSS), has identified as one of the key goals for improving health and the provision of healthcare for people with multiple chronic conditions “to increase clinical, community and patient-centered research.” In their linked commentary of this special journal issue, Parekh and Goodman identify and consider the potential impact of a number of related research initiatives supported by the National Institutes of Health and the Agency for Health Research and Quality, particularly focusing on two very specific areas: behavioral medicine and secondary analyses of available datasets. In this paper, I comment on both documents and discuss the opportunities offered by the current approaches and highlight related research needs; in particular, the need for an improved and expanded conceptual model of healthcare for people with multimorbidity, and the need for further exploration of the use of multimorbidity-relevant outcomes as part of usual clinical practice.
Improving the External Validity of Clinical Trials: The Case of Multiple Chronic Conditions
Authors: Martin Fortin , Susan Smith M.
Published: June 2014

The U.S. Department of Health and Human Services vision and strategic framework on multiple chronic conditions (MCCs) incorporates recommendations designed to facilitate research that will improve our knowledge about interventions and systems that will benefit individuals with MCCs (or multimorbidity). The evidence base supporting the management of patients with MCCs will be built through intervention trials specifically designed to address multimorbidity and identification of MCCs in participants across the clinical trial range. This article specifically focuses on issues relating to external validity with specific reference to trials involving patients with MCCs. The exclusion of such patients from clinical trials has been well documented. Randomized control trials (RCTs) are considered the “gold standard” of evidence, but may have drawbacks in relation to external validity, particularly in relation to multimorbidity. It may, therefore, be necessary to consider a broader range of research methods that can provide converging evidence on intervention effects to address MCCs. Approaches can also be taken to increase the usefulness of RCTs in general for providing evidence to inform multimorbidity management. Additional improvements to RCTs would include better reporting of inclusion and exclusion criteria and participant characteristics in relation to MCCs. New trials should be considered in terms of how they will add to the existing evidence base and should inform how interventions may work in different settings and patient groups. Research on treatments and interventions for patients with MCCs is badly needed. It is important that this research includes patient-centered measures and that generalizability issues be explicitly addressed.
VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer
Authors: Castilla María Ángeles , López-García María Ángeles , Atienza María Reina , Rosa-Rosa Juan Manuel , Díaz-Martín Juan , Pecero María Luisa , Vieites Begoña , Romero-Pérez Laura , Benítez Javier , Calcabrini Annarica , Palacios José
Published: June 2014

Vestigial-like 1 (VGLL1) is a poorly characterized gene encoding a transcriptional co-activator structurally homologous toTAZandYAPthat modulates the Hippo pathway inDrosophila. In this study, we examined the expression ofVGLL1and its intronic miRNA, miR-934, in breast cancer.VGLL1and miR-934 expression miRNA profiling was carried out on frozen samples of grade 3 invasive ductal carcinomas. VGLL1 protein was also examined in 433 sporadic andBRCA1-associated breast carcinomas on tissue microarrays. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to confirm differences inVGLL1and miR-934 expression in different breast cancer subtypes, and to correlate their expression with that of other genes and miRNAs. Of 28 miRNAs differentially expressed in estrogen receptor (ER)-positive and ER-negative grade 3 breast carcinomas, miR-934 was most strongly upregulated in ER-negative carcinomas, and its expression was correlated with that ofVGLL1. NuclearVGLL1expression was observed in 13% of sporadic breast carcinomas, and whileVGLL1was only occasionally found in luminal A (0.70%) and B (5.60%) carcinomas, it was often expressed in HER2-positive (17%), triple-negative (TN) breast carcinomas (>40%) andBRCA1-associated TN carcinomas (>50%). These findings were confirmed in the TCGA dataset, which revealed positive associations with luminal progenitor genes (GABRP,SLC6A14,FOXC1,PROM1, andBBOX1) and strong negative correlations with ER-associated genes (ESR1,C6ORF211,GATA3, andFOXA1). Moreover,VGLL1expression was associated with reduced overall survival. In conclusion,VGLL1and miR-934 are mainly expressed in sporadic andBRCA1-associated TN basal-like breast carcinomas, and their coordinated expression, at least partially mediated by the direct modulation ofESR1, might be involved in the maintenance of a luminal progenitor phenotype.
Islamic Legal Literature and Substantive Law in Indonesia
Authors: Lubis Nur Ahmad Fadhil
Published: June 2014

This article discusses the development and diversity of thought and practice of Islamic law Muslims in Indonesia, particularly in the areas of family and inheritance. In discussing Islamic law (shari'a or fiqh), the main focus of this paper is the position and contribution of Islamic law in the context of the national legal system. To that end, the proposed law reform and successfully passed will be used as the unit of analysis, in particular two of the New Order government legislation, namely marriage law in 1974 and 1991 Compilation of Islamic Law.DOI: 10.15408/sdi.v4i4.765
An Empirical Assessment of Divorce Law in Indonesia
Authors: Cammack Mark , Young Lawrence A. , Heaton Tim B.
Published: June 2014

A discussion of the effect of the marriage Act 1974 against divorce behavior Muslim community in Indonesia can be said to be rare. Various writings that discuss the application of these laws focus more on aspects of institutional, legal and political.DOI: 10.15408/sdi.v4i4.766
Al-Tafkīr al-Islāmī ‘an Taḥrīr al-Mar’ah bi Indūnīsiyā
Authors: Netri Emzi
Published: June 2014

The generally weak position of women in Muslim  society  has given birth  to a movement and  thought  among  Indonesian  Muslims  concerning women's emancipation. Prominent figures have critized Muslim undersanding of women's position inherited from generation  to generation for  inferior and subordirate  position of women  in socicty. According to these figures,  Islam is God's mercy for all and, as such, Islam  cannot  possibly  treat men  as special while regarding women as having a lower status. Although  critical of how Islam understood women status,  their conceptualization  and articulation of the problem has differed according to the historical  period and context in question.DOI: 10.15408/sdi.v4i4.769
Al-Idārah al-Islāmiyyah bi Indūnīsiyyā
Authors: Hamzah Alirman
Published: June 2014

For some people, religion is often regarded as obstacles in the development of society. However, not all matters relating to the development, both in political, economic and social, hampered by religious factors. In fact, not a few religious factors play a very positive role in community development. In that regard, the founder of the Indonesian state, from the beginning has thought to do a kind of bureaucratization of religious issues, particularly Islam.There is a common assumption in modernization theory that religion represents an obstacle to modern social development. Despite this assumption, and despite the adherence of Indonesia'a New Order ideologues to modernization theory, the Indonesian goverment still recognizes the positive contibution to social development provided by religion.DOI: 10.15408/sdi.v5i1.762
Pilgrimages and Local Islam on Java
Authors: Jonge Huub de
Published: June 2014

For muslims with sufficient means at their disposal, the hajj the pilgrimage to Mecca, is one of the ritual obligations of their faith. It is, however, not the only pilgrimage that is made by Muslims. In almost all Islamic countries one finds sacred places that are visited by pilgrims. Indonesia, for example, has thousands of Islamic pilgrim sites scattered over the many islands. Most of them are only of local or regional importance, but some are national or even internationally renoened religious centres. The largest pilgrim sites attract hundreds of thousands of visitors each year. For a great number of sanctuaries, it is not posibble to establish when the site become a pilgromage site. Some date from pre-Islamic times and at a later date were incorporated into the Islamic tradition.DOI: 10.15408/sdi.v5i2.751
Mahfūz al-Tirmisī (d. 1338/1919): An Intellectual Biography
Authors: Mas‘ud Abdurrahman
Published: June 2014

This paper describes the journey of intellectual Mahfouz al-Tirmisi as scholars who came from the farthest regions of the Islamic world, which ultimately able to develop themselves into well-known scholars in the Middle East and a lecturer in classical Islamic science center, Masjid al-Haram. Moreover, the success that Mahfouz has also contributed significantly in establishing the intellectual relationship between scholars archipelago with the Middle East. This also paved the way for the advancement of educational institutions of traditional Islam in Southeast Asia.DOI: 10.15408/sdi.v5i2.752
Islam Observed: The Case of Contemporary Malaysia
Authors: Metzger Laurent
Published: June 2014

The phenomenon of the rise of Islam in Malaysia does not attract much attention of observers when compared with the same phenomenon in the countries of the Middle East, North Africa, Central or South Asia. This paper attempted to review comprehensively the development of Islam in Malaysia since obtaining its independence from Britain in August 1957.DOI: 10.15408/sdi.v5i2.753
Wacana Baru Islam-Jawa
Authors: Burhanudin Jajat
Published: June 2014

This paper is a review of the book M.C. Ricklefs,The Seen and Unseen Worlds in Java: History, Literature and Islam in the Court of Pakubuwana II 1726-1749, (Honolulu: Asian Studies Association of Australian in association with Allen & Unwin and University of Hawaii Press, 1998).As for as the Indonesian studies are concerned,  Java has become the most various points of view, concerning the javanese society and culture. The book by M.C Ricklefs, which is under discussion, can be said to have specific importance.DOI: 10.15408/sdi.v5i2.757
Notes Towards the History of Qur'anic Exegesis in Southeast Asia
Authors: Feener R. Michael
Published: June 2014

Aktivitas penulisan tafsir di Dunia Melayu atau Asia Tenggara telah dimulai sejak beberapa abad lalu. Meskipun masih dalam bentuk elementer, sejak abad 17 wilayah ini telah memproduksi tafsir. Sebuah manuskrip melayu asal Aceh yang tersimpan di Universitas Cambridge menunjukkan bahwa teknik penulisan dan metode penafsiran yang diterapkan saat itu masih tergolong sederhana. Manuskrip ini yang merupakan tafsir surat al-Kahfi ditulis dengan tinta merah disertai terjemahan serta komentar yang ditulis dengan tinta hitam.DOI: 10.15408/sdi.v5i3.739
Kebangkitan Islam dan Negara Beberapa Kasus dari Asia Tenggara
Authors: Ali-Fauzi Ihsan
Published: June 2014

Artikel ini merupakan review buku Robert W. Hefner dan Patricia Horvatich (eds.), Islam in an Era of Nation States: Politics and Religious Renewal in Muslim Southeast Asia (Honolulu: University of Hawaii Press, 1997)DOI: 10.15408/sdi.v5i3.743
The Origin of the Islamic Reform Movement in Minangkabau Life and Thought of Abdul Karim Amrullah
Authors: Djamal Murni
Published: June 2014

Salah seorang ulama di Minangkabau, Sumatera Barat yang mempelopori gerakan pembaruan Islam adalah Abdul Karim Amrullah, yang kelak perjuangannya dilanjutkan oleh HAMKA. Pemikiran pembaharuan Abdul Malik Amrullah menggoreskan titik penting dari matarantai perkembangan pembaruan di kalangan masyarakat Muslim Indonesia. Hubungan yang terjalin antara ulama Minangkabau dengan tokoh-tokoh pembaharuan yang datang kemudian, baik melalui pendidikan maupun politik, menggambarkan bagaimana sebuah pemikiran keagamaan menyebar luas melintasi batas wilayah dan komunitas keagamaan di Nusantara.DOI: 10.15408/sdi.v5i3.744
Nahdlatul Ulama, Abdurrahman Wahid and Reformation: What Does NU's November 1997 National Gathering Tell Us?
Authors: Barton Greg , Feillard Andrée
Published: June 2014

A year in politics almost anywhere is a long time, in Indonesia the twelve month period from November 1997 to November 1998 was a very long time. Not since the mid 1960s had so much taken place in one year. For Nahdlatul Ulama (NU), Indonesia's thirty to forty million strong traditionalist Islamic organization, as for almost every other organization in Indonesia, the year was an extraordinary one.DOI: 10.15408/sdi.v6i1.745
Muslim Intellectuals in Southeast Asia
Authors: Federspiel Howard M.
Published: June 2014

Intellectual groups have always been important in Islamic societies and Muslim communities in Southeast Asia have been no exception. This study posits that there are four primary Muslim intellectual groups functioning in the six Muslim communities of the region. It will concentrate on a description of these four groups, discuss their spheres of activity, and anlyze their reaction to several impotrtant political and cultural factors extant in the Southeast Asian region.DOI: 10.15408/sdi.v6i1.746
Diaspora Hadrami di Nusantara
Authors: Burhanudin Jajat
Published: June 2014

The development of Hadrami society, or overseas Arab communities in general, in the Indian Ocean countries have attracted some scholars to study in more detail,especially some aspects concerning the way the Hadramis live and cope with various problems they have in their overseas countries.  In the Malay-Indonesia state, the Hadrami society have developed as a vital community group having important position for beyond their traditional role as "the carriers of Islam" (da'wah). In terms of economics, for instances, some Hadrami even succeed in making big-scale business, and some of them appears, in terms of politics, as the ruling political elite.DOI: 10.15408/sdi.v6i1.750
New Trends of Islamic Resurgence in Contemporary Malaysia: Sufi-Revivalism, Messianism, and Economic Activism
Authors: Hamid A. Fauzi A.
Published: June 2014

This paper, based on research entitled  "Islamic Resurgence in the Periphery: A Study of Political Islam  in Contemporary Malaysia with Special Reference  to the Darul Arqam Movement 1968-1996" (University of Newcastle upon Tyne,  1998), draws upon the systematic, full-blown  government repression of Darul Arqam, a sufi revivalist movement, in 1994. The "Darul Arqam challenge"  casts a significant  light on the various  tactics, methods and strategies  pursued  by Islamic movements in their  route  to power. This paper recognizes  that an analysis of the "Darul Arqam  challenge" is incomplete without a consideration  of long-term  structural  processes putting the 1994 events within a broader historical and ideological perspective. Of particular importance is the gradual concoction of a specific organizational and sociopolitical doctrine, concomitant with the execution of a dynamic economic  enterprise. It is argued that the elegant combination between theory and practice, in implementing Islam in as comprehensive  a manner as possible, serves as the main distinction between Darul Arqam and other contemporary Islamic movements not only in Malaysia but also throughout the ummah.DOI: 10.15408/sdi.v6i3.722
Al-Ittijah al-Ṣūfī wa al-Adab al-Sāmī fī al-Adab al-Indūnīsī al-Mu’āṣir
Authors: Nursomad Nursomad
Published: June 2014

The article is a study on the strength of the sûfi elements in modern Indonesian literary discourse.  Having explored the discourse on Sufism in the works of literature by the sûfi poets mentioned above,  the article discusses the socio-political and religious  context in which this transcendental  literature emerged. And in this case there are at least twoDOI: 10.15408/sdi.v6i3.726
Umat dalam Kontes Perumusan Identitas Muslim Filipina
Authors: Darmadi Dadi
Published: June 2014

This theme is discerningly discussed by George C. Decasa, in this book derived from his doctoral dissertation, which he currently completed from the Gregorran UIniversity, Rome, Italy. Decasa begins his work with an over flowing elaboration of the word umma. He follows Fazlur Rabman's recommendation to study the meanings of umma in various Qur'anic verses in the order of their revelation to get a full understanding of the term. Decasa impressively uses a phenomenological approach in understanding the interpretation of Qur'anic exegesis of the word umma. Employing a contextual historical reading enables him to figure out the reflections of umma in some different particular historical contexts. In the context of the Qur'an, as shown in its varied commentaries, umma as a religious community, is likely open to various interpretations. In general, however, the term umma in the Qur'an reflects a reference to humankind as one community. The mainstream of belief in Islamic tradition is that God sent prophets to different peoples at different times, where they preached one religion and one religious community. In particular, the term umma may also suggest People of the Book (Ahl al-Kitab), Abraham and certainly Muslim community.DOI: 10.15408/sdi.v6i3.727
Islam and Dutch Colonial Administration: The Case of Panghulu in Java
Authors: Hisyam Muhammad
Published: June 2014

This article examines the interaction between Islam and the Dutch East-Indies administration in Java from its formation in the early eighteenth century to the end of Dutch administration in 1942, with respect to religious courts and the role of the pangulu. This article argues that the interaction between colonial government and the pangulu institution rested on the hypothetical proposition that both the colonial ruler and the religious courts needed each other. On one hand, the Dutch viewed that the religious courts should be maintained in order to reduce the possibility of an eruption of an undesirable situation, such as a rebellion. On the other hand, for the pangulu, it was felt that the institution might be lost in the absence of official appointment by the ruling authority.DOI: 10.15408/sdi.v7i1.717
Tārikh al-Ma’had al-Turāthī wa Thaqafātuhu
Authors: Mas'ud Abdurrahman
Published: June 2014

Within the Indonesian context, the history of pesantren cannot be alienated from that of Walisongo (The Nine Saint), who were said to be responsible for the spread of Islam in Java in the 16th-17th centuries. Maulana Malik Ibrahim (died 1419), the "spiritual father" of the Walisongo, is usually considered by the santri comntunity in Java to be "the teacher of the teachers" of the pesantren tradition. Some of the well-known pesantrens in Java, claim that they received their inspiration from the dakwah (ie.Islamic propagation) of Maulana Malik lbrahim. Moreover, oral histories indicate that old and influential pesantrens outside of Java -such as Nahdlatul Watan, established in 1934 in East Lombok NTB and now home for about 10,000 santris scattered throughout its branches- also had Inspiration from the Walisongo teaching. This, in turn, has made Maulana Malik lbrahirn as the father of the Walisongo even more well-know.DOI: 10.15408/sdi.v7i1.718
Al-Ma’had al-Turāthī wa Tajdīd al-Niẓām al-Ta’līmī bi Indūnīsiyā
Authors: Fachruddin Fuad , Abbas Sirojuddin
Published: June 2014

This article explores some aspects of pesantren education with respect to the plan to consolidate the administration of both Islamic and secular education system. This is an important matter since there are certain basic weaknesses in the national educational system that call for attention, including problems of students' empowerment and the content of education. Since pesantren has a relatively good record in training and education, it can contribute its experience in the development of national education as whole. Previous studies show that the system of pesantren education has two strengths. First, the presence of a strong interest in learning among the santi (students of pesantren) or, in educational terms, a high level of mastery learning. The second aspect in which pesantren is strong is in the participation of community. The establishment of pesantrens all over Indonesia basically reflected the demand as well as the need of communities themselves, and because of that the participation of communities in running individual institutions is quite high.DOI: 10.15408/sdi.v7i1.719
Pasang Surut Hubungan Agama-agama Jawa
Authors: Jamhari Jamhari
Published: June 2014

This book is the most recent publication presenting an anthropological study on the Javanese religion and culture. The seminal work of Clifford Geertz, The Religion of Java (1960), seems to have inspired a number of scholars to study further the complex entities of Javanese religion. The book of Mark Woodward, Islam in Java: Normative Piety and Mysticism in the Sultanate of Yogyakarta (1989), is one of the scholarly works inspired by the division of Javanese religion by Clifford Geertz into abangan, santri and priyayi. The same topic can also be found in the work by Robert Hefner, Hindu Javanese: Tengger Tradition and Islam (1985). However, different from Clifford Geertz who holds the opinion that Javanese religion-albeit plural in an appearance-is basically established on the basis of Hindu-Buddhist, religion the two mentioned scholars state that Islam in an important basis of the Javanese religion.DOI: 10.15408/sdi.v7i1.720
Facing the New Millenium: The 30th NU Congress at the End of the 20th Century
Authors: Hasyim Syafiq , Darmadi Dadi
Published: June 2014

Nahdlatul Ulama (NU), the Indonesian largest traditionalist Muslim organization with more than 30 million followers nationwide, faced the challenge of the new millennium by successfully bolding its 30th congress (muktamar) at Pesantren Lirboyo in Kediri, East Java. Approximately one million Nahdliyyins, as NU followers, are called to have enjoyed one of NU's biggest event cultural and ceremonial events for five day from November 22nd until November 27th 1999. The majority of participants came from Java, but many others came from as far away as Sumatera, Sulawesi, Kalimantan and Maluku.DOI: 10.15408/sdi.v7i1.721
Cultural Presentation of the Muslim Middle Class in Contemporary Indonesia
Authors: Hasbullah Moeflich
Published: June 2014

One approach to understanding the platform of New Order politics is to view it as having been a contest between Indonesian Political groups for access to power. Throughout the New Order period, economic capital was largely in the hands of a Chinese minority, while political capital was in the hands of the abangan Javanese priyayi. At the same time, the santri (the 'true Muslims'), have been economically and politically marginalized. They have been, as Wertheim (1975) put it, "the outsiders". Since the 1980s, thanks to the success of development efforts, Indonesia has been undergoing rapid economic development and a massive educational transformation. These economic and educational transformations have increased the percapita income and standard of living, mostly in urban areas, and expanded the 'middle class'. For the urban Muslim community -which represent the bulk of those most affected by development- the economic and educational transformations have not only resulted in class transformation creating a 'middle rank', but also caused the mobilization of the decades-marginalized santri who have embraced the project of cultural Islam.DOI: 10.15408/sdi.v7i2.708