bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN ADABOOST UNTUK MENINGKATKAN AKURASI NAIVE BAYES PADA PREDIKSI PENDAPATAN PENJUALAN FILM
Authors: Nurlaela Dini
Published: June 2022

For economists and financial experts predicting the success of doing business is very interesting. With the data analytics the prediction process has been facilitated by the past data stored to find out what will happen in the future. This research was conducted to facilitate the film industry players in considering the factors that can influence the income of the film to be produced. The naive bayes method is a popular machine learning technique for classification because it is very simple, efficient, and has good performance on many domains. But naive bayes has a disadvantage that is very sensitive to too many features, thus making the accuracy to be low, in this case the adaboost method to reduce bias so that it can and improve accuracy from naive bayes. Validation is done by using 10 fold cross validation while measuring accuracy using confusion matrix and kappa. The results showed an increase in the accuracy of Naive Bayes from 83.22% to 84.44% and the kappa value from 0.706 to 0.731. So that it can be concluded that the application of adaboost on 2014 & 2015 CSM film data is able to improve the accuracy of the Naive Bayes algorithm
PERANCANGAN SISTEM INFORMASI HELPDESK TICKETING BERBASIS WEB PADA PT. HFSA TANGERANG
Authors: Hariyanto Muhadi , Kholiq Muhammad , Yani Ahmad , Narti Narti
Published: June 2022

Perkembangan sistem informasi di masa sekarang sudah banyak membantu berbagai aspek pekerjaan. Helpdesk merupakan unit yang menangani masalah IT dalam suatu organisasi. sistem kerja Helpdesk yaitu melayani kebutuhan pelanggan yang memiliki keluhan dengan cara sistem penomoran. Penggunaan teknologi helpdesk menjadi solusi tepat untuk perusahaan besar, penggunaan teknologi informasi  semakin penting keberadaanya untuk mengelola informasi dengan cepat dan akurat dan mampu menyimpan dalam suatu history yang bisa dipertanggung-jawabkan untuk dijadikan acuan dan referensi pembenahan sistem di masa mendatang.  PT. Henkel Footwear and Speciality Adhesives (HFSA) Tangerang adalah perusahaan yang bergerak dibidang industri teknologi perekat. Dalam menunjang proses bisnis perusahaan, PT. HFSA Tangerang menggunakan sistem komputer dan terdapat divisi IT yang menangani berbagai permasalahan berkaitan dengan teknologi informasi. Proses manajemen permasalahan masih menggunakan pencatatan manual, sehingga terdapat kendala antar teknisi atau resolver team dalam menangani permasalahan. Dengan metode menual, penyajian laporan juga tidak bisa dilakukan secara cepat. Sehingga untuk mempermudah divisi IT dalam mengelola permasalahan yang masuk, maka dibutuhkan sistem yang dapat menangani kebutuhan tersebut. Sistem informasi helpdesk ticketing berbasis web dapat diakses menggunakan web browser dari berbagai sistem operasi. Model pengembangan yang digunakan dalam perancangan sistem informasi helpdesk ticketing ini adalah RAD (Rapid Application Development) yang terdiri dari beberapa tahapan. Tujuan dari penelitian ini adalah sistem helpdesk ticketing berbasis web yang diaplikasikan dapat bermanfaat bagi karyawan PT. Henkel Footwear and Speciality Adhesives (HFSA) Tangerang, terutama divisi IT dalam mengelola incident ticket.
First confirmation of salmonid alphavirus infection in rainbow trout in Bosnia and Herzegovina and Serbia
Authors: Radosavljevic V , Jazic A , Milicevic V , Bozidar S , Zuko A , Glisic D , Maksimovic-Zoric J , Olesen NJ
Published: June 2022

Sleeping disease is a highly infectious viral disease caused by salmonid alphavirus subtype 2 (SAV2 FW), affecting mainly rainbow trout Oncorhynchus mykiss farmed in freshwater. During March to May 2014, disease episodes with clinical signs of sleeping disease in rainbow trout fingerlings occurred almost simultaneously in 2 trout farms located in Bosnia and Herzegovina (BiH) and Serbia. The infection of rainbow trout with SAV2 FW in 2 farms was confirmed by virus isolation and molecular methods. This is the first isolation and molecular characterization of SAV2 FW in BiH and Serbia.
Auto-memoration, Con-memoration: A ‘Self’/Reflection
Authors: Anderson Nicole
Published: June 2022

Exploring who, what and how we remember, this piece proposes that to remember requires, on the one hand, an auto-memoration (the means by which we remember ourselves, and therefore how we shape and present ourselves to others), and at the same time, on the other hand, auto-memoration always detours through the world and through the other, which requires ‘con-memoration’ (remembering with the other). Referring to Derrida and Nancy, this piece argues that the memories of ourselves, and of others, is always already mediated because structured by differance and the other, and thus entails also a forgetting.
Mourning Alone Together
Authors: Abbeele Georges Van Den
Published: June 2022

In the current context of pervasive loss and the absence of publicly commemorative rituals, this essay proposes a reading of Freud’s ‘Mourning and Melancholia’ that questions the presupposition that mourning must come to an end as the completed work of memories recalled only to be sent off. While melancholia may be presented as the invention of an imaginary loss, would not the real pathology of mourning be the summary or precipitous declaration of its end? Whether we understand mourning as completable in itself or as impossibly seeking an asymptote it can never reach, whether the work of mourning is terminal or interminable, the name of the deceased stands as what is left, not only as what is inscribed on a gravestone and outlasting any living memory, but also as the very bounds of memory as sense. Not so much the end of mourning, then, as its reiterative reaffirmation, commemoration comes down to a practice of active mourning (like active forgetting), not an ‘end’ but its retreat, its appearing/disappearing as the incessant redrawing of its withdrawal. Not a self-deprecating melancholia, nor the indulgent luxury of nostalgia, but the endless inscription of a name whose loss we can never stop mourning.
Glas Struggles
Authors: Mercier Thomas Clément
Published: June 2022

This essay stages an encounter between several texts by Jacques Derrida (notably Memoires – for Paul de Man, Life Death, and Glas) which delineate the contours of what could be called a ‘memorial agonistics’. Through readings of Marx, Nietzsche and Freud, Derrida shows that memory and commemorations always involve struggles in nomination and classification, jealous movements of appropriation and expropriation of the departed, wars in and for the name converging towards the imposition of some countersignature. These violent plays of preservation and substitution seem always to take place around the enigmatic figure of the mother – a monumental corpse instantiated in the essay through the name ‘Notre-Dame de la Garde’.
Socio-ecological and economic paradigm of sustainable development of rural territories of Ukraine
Authors: Bendasiuk O. , Shpylova Y. , Neklyudova T. , Sakharnatska L.
Published: June 2022

The article, based on a study of the key provisions of the concept of sustainable development and the essence of the concepts of «paradigm» and «system» found that the modern socio-ecological-economic paradigm is a system of selective views, compromises and actions of society. through available economic, institutional, financial, social mechanisms and tools to harmonize relations between the population, government and business. It is determined that the formation of socio-ecological-economic paradigm of sustainable development involves its territorial differentiation, which means the transition to a model that takes into account the economic and natural specifics of certain areas, ensuring a balance between economy, social sphere and ecology.
It is proposed to consider the socio-ecological-economic paradigm of sustainable development according to the types of relationships formed between its components: economic-ecological, which provide for the impact of economic activity on the environment. Reflecting the impact of the environment on production conditions, form the raw material base; socio-economic relations provide the spheres of economic activity with labor resources, through which the research and production process takes place; socio-ecological reflect the interaction of the environment and society, their mutual influence.
The purely economic ties that arise due to the influence of economic laws, and are the basis for the formation of certain patterns of economic processes and relations, and social ties that arise during the functioning of society and characterize the features and stages of social relations; institutional ties are formed in the process of historical development of the socio-economic environment in the context of reconciling the interests of social groups, etc. A scheme of sustainable development of rural areas as complex systems has been developed in three-dimensional space, which includes, depending on the availability of key links in the system and provides for deviations from its sustainable development.
Problems of value-time social dimension of economic-informational and production processes of marketing of enviromental management in the agrosphere of Ukraine
Authors: Kovaliv O. , Lazarenko V. , Morozov O.
Published: June 2022

Experimental-analytical researches of problems of value-time measurement of economic-informational and production processes of marketing of nature management in agrosphere of Ukraine are carried out. The main prerequisites and ways to solve existing problems through the functioning of the system of socially oriented marketing (SSSM) — in the process of land reform in Ukraine — based on current Constitution of Ukraine as a new paradigm that takes into account the objective laws of animate and inanimate nature and society.
It is proved that constitutionally motivated socio-economic development in Ukraine can take place on the basis of acquired scientifically based knowledge of «constitutional pragmatism» within the cognitive land economy, the essence of which is clearly embedded in the pyramid model of the cognitive land economy — the so-called Cognitive Kovaliv.
It is established that the expansion of domestic and foreign markets by domestic highly liquid products, especially organic and environmentally friendly food, in the formation of which natural resources participate as natural objects of property of the Ukrainian people, generates unborrowed investment capital of the nation domestic products, and as a consequence — an increase in national net income. It is proved that SSSM plays the role of a crucial stimulator of growth of well-being of all citizens of Ukraine who are absolute co-owners of land and its natural resources as natural objects of law of the Ukrainian people, forming a comfortable space for their (citizens of Ukraine) state.
Planning documentation as a management tool of land of public use
Authors: Dorosh O. , Tretiachenko D.
Published: June 2022

The article defines the concept of public lands located both within and outside settlements. It is established that the legal regime of public lands is formed by legislative and regulatory documents that determine the rules of placement of relevant facilities, namely public buildings, and their use.
It has been determined that public lands have a public use regime, but restrictions may be imposed on their use. It has been established that public lands belong to all nine categories of land and the affiliation of individual public lands to each of the land categories has been determined. Accordingly, the legal regime in different public lands differs significantly. The irrationality and inexpediency of separating public lands into a separate category of lands are substantiated.
It has been established that planning documentation is an effective tool for the management of public lands, and the affiliation of such lands to one of the categories allows to determine which of the planning documents is relevant for the management of these lands. The land management, urban planning and interdisciplinary planning documentation is analysed and planning documents, the development of which is relevant and expedient for the management of public lands of certain categories of land are established. It was concluded that the formation of an integrated community space and effective management of its lands, including public use, it is important to systematically use land management and urban planning documentation on the basis of a community approved strategy.
Using digital marketing approaches in biotechnology production
Authors: Haidar A. , Zinovchuk N. , Lazarenko V.
Published: June 2022

The effectiveness of using digital marketing tools and various functions for biotechnological production is substantiated. Their main functions, advantages, as well as the main criteria, are covered, indicating their effectiveness at the present stage and the possibility of their future use in the future. The stages of conducting research on the market of biological preparations on agricultural lands and enterprises that are direct consumers of biopreparations are substantiated. Also illuminates the connection of the marketing link between manufacturers of data at the C2C level and their feedback. The expediency of using each individual instrument, depending on the situation of a biotechnological enterprise in the market, as well as the situation where the company is expedient to pay attention to the indicated indicators. The stages of using targeted advertising for biotechnological companies are determined, the efficiency of launching an advertising campaign in a digital plane is analyzed. In particular, the main approaches to using targeted advertising are identified, stages and real examples of modern biotechnological companies operating in the Ukrainian market, and, accordingly, reflect the real state of development of digital marketing tools in the biotechnological branch of agriculture in Ukraine.
Water and physical properties of soil as a factor of phytocenotic cover formation of devastated lands
Authors: Mudrak O. , Mahdiichuk A.
Published: June 2022

An important obligatory environmental aspect on post-mining areas is the implementation of technical and biological reclamation of mining landscapes. One of the stages of technical reclamation on devastated lands is the coverage by fertile or potentially fertile material. During this research we proposed a saponite clay using as a potentially fertile material to improve the structure and water-physical properties of the sandy substrate, because it depends the next course of biological reclamation. In this article it is experimentally proved that the application of saponite clay improves the indicators of total, capillary and hygroscopic moisture capacity, also the indicators of humidity on the verge of rolling and water lifting capacity. This contributes to the formation of a solid phytocenotic cover of devastated lands, which can come forward as regenerative areas of the regional ecological network.
Еconomic assessment of growing strawberries underdifferent plant protection systems in the Right bank Forest-steppe of Ukraine
Authors: Poprotska V. , Mostoviak S. , Mostoviak I.
Published: June 2022

The article presents the results of the studies during 2016–2020 on the effectiveness of growing garden strawberries of remontant varieties Murano and Vivara using various chemical preparations in the system of plant protection against pests in the Right Bank Forest-Steppe of Ukraine. It has been established that growing garden strawberries of Murano variety is more profitable than Vivara variety. On average during 2016–2020, the yield of Murano variety with the use of insecticides-acaricides was 33.22–33.44 t/ha and the yield increase was 16.48–16.70 t/ha. The yield of Vivara variety was 25.12–25.60 t/ha, and the increase in yield to control was 12.06–12.54 t/ha. The highest percentage of high-quality berries with a dry substance content of 12% was collected from Murano variety 48.2% using Apollo® (0.5 l ha) + Caesar™ (0.2 l/ha) + Mavryk™ (0, 6 l/ha), which is 2.2 times more than in the control and 8% than when using the reference plant protection system. Similarly, the highest percentage of high-quality berries of Vivaro variety (35.2%) was obtained with the use of insect-acaricide complex, which is 1.3 times more than the control. The studied protection systems (Masai®, 0.4 kg/ha + Biscaiia®, 0.8 l/ha; and Apollo®, 0.5 l/ha + Caesar ™, 0.2 l/ha + Mavryk ™, 0,6 l/ha) in terms of yield and a number of economic efficiency indicators were either at the level of the reference protection system (Sunmight®, 0.7 kg/ha + Mospilan®, 0.5 kg/ha) or slightly more cost-effective. With a slight increase in production costs for insecticides-acaricidal action, the level of profitability in the cultivation of Murano variety increased to 78.3–78.6% or 1.4 times, Vivara variety — to 71.4–72.0% or 1.6 times. The highest net profit at a low level of production costs was obtained by growing garden strawberries of both varieties using a set of preparations Apollo® (0.5 l/ha) + Caesar 0,2 (0.2 l/ha) + Mavryk™ (0.6 l/ha), which gives grounds to recommend the plant protection system for implementation.
Dynamics of soybean production in Ukraine and the world
Authors: Korobko A.
Published: June 2022

The article highlights the importance of soybeans as one of the main crops for society's food supply. Based on the analysis of statistical data on yield and soybean sowing areas in Ukraine and the world, ten world countries are leaders in soybean production and the place among them is determined by Ukraine. It has been confirmed that soybeans are a strategic crop in Ukraine, which stabilizes agriculture, increases fertility and nitrogen reserves of the soil, eliminates protein deficiency and helps solve the food problem. The increase in the gross harvest of soybeans is not only due to the expansion of sown areas, but also due to increased yields. To increase the efficiency of production of this crop, it is proposed to introduce a set of innovative solutions at different stages of production of this crop, as well as to use new, productive varieties. In many publications, the authors emphasize that 30–35% of success in growing soybeans depends on the correct choice of soybean variety.
Virtual assets through the prism of domestic practice: risk-orientedness and implementation
Authors:   Vinnytsia National Technical University, ZIANKO Vitalii , NECHYPORENKO Tetiana ,   Vinnytsia Technical Vocational College
Published: June 2022

Introduction. Nowadays digital technologies are generating new phenomena among which virtual assets in the diversity of their species and habitats are developing. Problem Statement. The analysis of modern scientific publications and research on the monitoring of virtual assets shows that at the theoretical level there is no single approach to the use of the conceptual apparatus on this issue. Purpose. The aim of the article is to deepen theoretical knowledge and practical skills of using virtual assets through the prism of domestic experience, as well as outlining the place, role, tasks, mechanism of operation, risk orientation and prospects of digital assets implementation as an innovative institutional form of money circulation in the conditions of globalization. Materials and Methods. To achieve this goal, methods and techniques of cognitive theory are used, such as observation, comparison, abstraction, historical and logical approach, analysis and synthesis, induction and deduction, establishing causal links between the development of processes and phenomena, tabular and graphical methods. Results. The current state and prospects of development of the mechanism of operations with digital assets are diagnosed. It is theoretically substantiated that virtual values are objects of legal regulation. The legislative acts which are called to regulate the virtual assets market are analyzed. Conclusions. It is stated that the vector dominants of the impact concerning virtual assets are aimed at the control and transparency of transactions with them, cybersecurity and user verification. The nature of modern money is observed in virtual currency – not material , but absolutely conditional, based on the mechanism of accounting of settlement obligations recognized by all participants. The main innovations and opportunities for implementing positive international practice of state regulation of the cryptocurrency market to Ukrainian realities are outlined.
Financial sector – source of stable financing of the economy
Authors:   SESE “The Academy of Financial Management”, DUNAEV Borys
Published: June 2022

Introduction. The world economy has been experiencing a systemic financial crisis since 2008, as a result of which highly developed countries have been in a state of depression and teetering on the brink of deflation. This crisis coincided in 2020 with the global crisis of a sharp decline in real GDP caused by the COVID-19 pandemic. The conditions for a possible entry of the country's economy into stable growth are ambiguous. Problem Statement. Highly developed countries have taken steps to regulate the sharp decline in real GDP due to the pandemic, leaving financial markets overflowing with cheap liquidity. This threatens to increase inflation, the collapse of stock markets and the continuation of the global financial crisis if cheap liquidity does not become an investment resource for sustainable financing. Purpose. Study of the interaction of the real and financial sectors in the country's economy through changes in the amount of cash in circulation and with the help of the state's investment policy on sustainable financing and determining the consequences of the collapse of the value of financial securities. Materials and Methods. The data of the International Finance Corporation was used, according to which, in particular, in emerging markets, there are opportunities for climate investment worth about 23 trillion dollars. US by 2030, while in Ukraine they are estimated at 73 billion dollars. USA. Results. A study of the interaction of real and financial sectors in the economy through the state's investment policy for sustainable financing and identified the consequences of the collapse of the value of financial securities. It has been determined that an increase in cash from the financial sector proportionally reduces inflation and a decrease increases it. Therefore, when targeting inflation within specified limits, the banking system must change the amount of cash in the economy in proportion to its change in the financial sector. With a constant amount of cash in the economy, inflation decreases proportionally if the cash of the financial sector and the currency balance increase. Conclusions. Government regulation of investment in the real sector and investment by the financial sector in stable financing may be another impetus for economic growth and overcoming the systemic financial crisis.
Hubungan Riwayat Penyakit Infeksi Dengan Kejadian Stunting Pada Balita Umur 24-59 Bulan Di Wilayah Kerja Puskesmas Marawola Kabupaten Sigi
Authors: Maineny Arie , Longulo Olkamien Jesdika , Endang Nur
Published: June 2022

Introduction: Stunting is a lack of nutrients due to insufficient nutrient accumulation. In 2019, the prevalence of stunting in Sigi Regency was 18.0%, with 3,542 cases (24.6%). Marawola Public Health Center is one of 19 Puskesmas in Sigi Regency, with a stunting prevalence of 28.05% in 2019 and 28.22% in 2020. Objectives: The purpose of this study was to determine whether there is a relationship between a history of infectious disease and the incidence of stunting in children aged 24-59 months in the operational area of ​​the Marawola Health Center, Sigi Regency. Methods: Case-control design with analytical survey method and retrospective approach. The population in this study were all children under five from the Marawola Health Center, Sigi Regency, with an age range of 24 to 59 months. This research technique uses purposive sampling by taking a sample of 41 cases and 41 controls. This research includes univariate and biavariate analysis, as well as chi square test. Results: Statistical tests showed a p-value of 0.000 and an OR of 0.111 between a history of infectious diarrheal disease and the incidence of stunting, as well as a p-value of 0.023 and an OR of 5.484 between a history of ARI infection and the incidence of stunting. Conclusion: The incidence of stunting in children aged 24-59 months is associated with a history of infectious diarrheal diseases and ARI infections. Implementation of the program in the form of stunting prevention education, prevention of infectious diarrheal diseases, and prevention of ARI.
 
ABSTRAK
Pendahuluan: Stunting adalah kekurangan zat gizi akibat akumulasi gizi yang tidak mencukupi. Pada tahun 2019, prevalensi stunting di Kabupaten Sigi sebesar 18,0 %, dengan 3.542 kasus (24,6 %). Puskesmas Marawola merupakan salah satu dari 19 Puskesmas Kabupaten Sigi, dengan prevalensi stunting sebesar 28,05 % pada tahun 2019 dan 28,22 % pada tahun 2020. Tujuan: Tujuan penelitian ini adalah untuk melihat adakah hubungan riwayat penyakit menular dengan kejadian stunting pada anak usia 24-59 bulan di wilayah operasional Puskesmas Marawola Kabupaten Sigi. Metode: Desain kasus kontrol dengan metode survei analitik dan pendekatan retrospektif. Populasi dalam penelitian ini semua balita dari Puskesmas Marawola Kabupaten Sigi, dengan rentang usia 24 sampai 59 bulan. Teknik Penelitian ini menggunakan purposive sampling dengan mengambil sampel 41 kasus dan 41 kontrol. Penelitian ini meliputi analisis univariat dan biavariat, serta uji chi square. Hasil: Uji statistik menunjukkan hubungan p-value 0,000 dan OR 0,111 antara riwayat penyakit diare menular dengan kejadian stunting, serta hubungan p-value 0,023 dan OR 5,484 antara riwayat infeksi ISPA dengan kejadian stunting. Kesimpulan: Kejadian stunting pada anak usia 24-59 bulan berhubungan dengan riwayat penyakit diare menular dan infeksi ISPA. Implementasi program berupa edukasi pencegahan stunting, pencegahan penyakit diare menular, dan pencegahan ISPA.
Gambaran Asupan Makanan dan Status Gizi pada Ibu Hamil di Huntara Kelurahan Petobo Kota Palu
Authors: Kusumawati Dwi Erma , Nurwidianti Nurwidianti , Hafid Fahmi
Published: June 2022

Introduction: Sufficient nutrient intake is vital for fetal growth and development during pregnancy. Stable food security supports adequate food consumption. Natural disaster that struck Palu City in 2018 had a negative influence on food security. Food intake and nutritional status among pregnant women in temporary housing in Petobo sub-district, South Palu sub-district are described in this study. Methods: The research method used in this study is descriptive. All pregnant women in temporary shelters were included in the population and samples, which totally 30 pregnant women. Data collected including MUAC and Food Recall for 24 hours over two non-consecutive days. The study results showed that the average intake was 1,370 kcal of energy, 232.7 grams of carbohydrates, 38.6 grams of protein, and 28.4 grams of fat. The majority for energy and macronutrient consumption are below 80% of the Indonesian RDA 2019. The average of Vitamin A 575.6 mcg, vitamin C 33.3 mg, vitamin B6 0.9 mg, calcium 679.5 mg, and zinc 4.2 mg are below 80% of the Indonesian RDA 2019. Only intake of Vitamin B9 and Iron is sufficient with an average intake of 511.3 mcg and 42.3 mg. The nutritional status of all pregnant women are not at risk of CED. In conclusion, intake of calories, macronutrient, and micronutrient are classified as inadequate except for vitamin B9 and Iron, and all pregnant women is not at risk of CED. It is suggested the diversify of diet by eating more locally grown foods and doing enough exercise.
 
 
ABSTRAK
Pendahuluan: Asupan zat gizi pada saat ibu hamil di perlukan untuk pertumbuhan dan perkembangan janin. Asupan makanan yang cukup di dukung adanya kestabilan ketahanan pangan. Bencana alam yang terjadi di kota palu pada tahun 2018 berdampak pada ketidakstabilan ketahanan pangan. penelitian ini menggambarkan asupan makanan dan status gizi pada ibu hamil di hunian sementara kelurahan Petobo kecamatan Palu Selatan. Metode: Penelitian ini menggunakan jenis penelitian deskriptif. Populasi dan sampel adalah semua ibu hamil yang berada di hunian sementara berjumlah 30 ibu hamil. Pengumpulan data berupa LILA dan Recal 24 jam selama 2 hari tidak berurutan. Hasil penelitian menunjukkan rata-rata asupan energi 1.370 kkal, karbohidrat 232,7 gr, protein 38,6 gr dan lemak 28,4 gr. sebagian besar asupan energi dan zat gizi makro masih <80% dari AKG. Asupan vitamin A 575,6 mcg, vitamin C 33,3 mg, vitamin B6 0,9 mg, kalsium 679,5 mg dan zink 4,2 mg  masih < 80% dari AKG. Hanya asupan Vitamin B9 dan fe cukup dengan rerata asupan 511,3 mcg dan 42,3 mg serta Status gizi semua ibu hamil tidak berisiko KEK. Kesimpulan bahwa semua asupan energi, zat gizi makro dan sebagian besar dari zat gizi mikro berkategori kurang. Asupan vitamin B9 dan Fe ibu hamil cukup dengan status gizi semua ibu hamil tidak berisiko KEK. Disarankan  untuk tingkatkan keanekaragaman makanan dari pangan lokal dan lakukan aktivitas fisik yang cukup.
Bioinformatics Approaches to Predict Mutation Effects in the Binding Site of the Proangiogenic Molecule CD93
Authors: Cicaloni Vittoria , Karmakar Malancha , Frusciante Luisa , Pettini Francesco , Visibelli Anna , Orlandini Maurizio , Galvagni Federico , Mongiat Maurizio , Silk Michael , Nardi Federica , Ascher David , Santucci Annalisa , Spiga Ottavia
Published: June 2022

The transmembrane glycoprotein CD93 has been identified as a potential new target to inhibit tumor angiogenesis. Recently, Multimerin-2 (MMRN2), a pan-endothelial extracellular matrix protein, has been identified as a ligand for CD93, but the interaction mechanism between these two proteins is yet to be studied. In this article, we aim to investigate the structural and functional effects of induced mutations on the binding domain of CD93 to MMRN2. Starting from experimental data, we assessed how specific mutations in the C-type lectin-like domain (CTLD) affect the binding interaction profile. We described a four-step workflow in order to predict the effects of variations on the inter-residue interaction network at the PPI, based on evolutionary information, complex network metrics, and energetic affinity. We showed that the application of computational approaches, combined with experimental data, allowed us to gain more in-depth molecular insights into the CD93–MMRN2 interaction, offering a platform for developing innovative therapeutics able to target these molecules and block their interaction. This comprehensive molecular insight might prove useful in drug design in cancer therapy.
Ralstonia solanacearum Infection Disturbed the Microbiome Structure Throughout the Whole Tobacco Crop Niche as Well as the Nitrogen Metabolism in Soil
Authors: Wang Zhaobao , Zhang Yuzhen , Bo Guodong , Zhang Yanping , Chen Yu , Shen Minchong , Zhang Peng , Li Guitong , Zhou Jie , Li Zhengfeng , Yang Jianming
Published: June 2022

Infections of Ralstonia solanacearum result in huge agricultural and economic losses. As known, the proposal of effective biological measures for the control of soil disease depends on the complex interactions between pathogens, soil microbiota and soil properties, which remains to be studied. Previous studies have shown that the phosphorus availability increased pathobiome abundance and infection of rhizosphere microbial networks by Ralstonia. Similarly, as a nutrient necessary for plant growth, nitrogen has also been suggested to be strongly associated with Ralstonia infection. To further reveal the relationship between soil nitrogen content, soil nitrogen metabolism and Ralstonia pathogens, we investigated the effects of R. solanacearum infection on the whole tobacco niche and its soil nitrogen metabolism. The results demonstrated that Ralstonia infection resulted in a reduction of the ammonium nitrogen in soil and the total nitrogen in plant. The microbes in rhizosphere and the plant’s endophytes were also significantly disturbed by the infection. Rhodanobacter which is involved in nitrogen metabolism significantly decreased. Moreover, the load of microbial nitrogen metabolism genes in the rhizosphere soil significantly varied after the infection, resulting in a stronger denitrification process in the diseased soil. These results suggest that the application management strategies of nitrogen fertilizing and a balanced regulation of the rhizosphere and the endophytic microbes could be promising strategies in the biological control of soil-borne secondary disasters.
Hydrogels in Spinal Cord Injury Repair: A Review
Authors: Lv Zhenshan , Dong Chao , Zhang Tianjiao , Zhang Shaokun
Published: June 2022

Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability and tends to occur among the young, seriously affecting patients’ lives and quality of life. The key aims of repairing SCI include preventing secondary nerve injury, inhibiting glial scarring and inflammatory response, and promoting nerve regeneration. Hydrogels have good biocompatibility and degradability, low immunogenicity, and easy-to-adjust mechanical properties. While providing structural scaffolds for tissues, hydrogels can also be used as slow-release carriers in neural tissue engineering to promote cell proliferation, migration, and differentiation, as well as accelerate the repair of damaged tissue. This review discusses the characteristics of hydrogels and their advantages as delivery vehicles, as well as expounds on the progress made in hydrogel therapy (alone or combined with cells and molecules) to repair SCI. In addition, we discuss the prospects of hydrogels in clinical research and provide new ideas for the treatment of SCI.
Government by Code? Blockchain Applications to Public Sector Governance
Authors: Bustamante Pedro , Cai Meina , Gomez Marcela , Harris Colin , Krishnamurthy Prashant , Law Wilson , Madison Michael J. , Murtazashvili Ilia , Murtazashvili Jennifer Brick , Mylovanov Tymofiy , Shapoval Nataliia , Vee Annette , Weiss Martin
Published: June 2022

Studies of blockchain governance can be divided into analyses of the governance of blockchains (such as rules and power dynamics within a given network) and governance by blockchains (such as how blockchains can be implemented to improve self-governance of community-based peer production networks). Less emphasis has been placed on applications of distributed ledgers to public sector governance. Our review clarifies that the decentralization and distributive features that enable blockchains to link up loosely connected private organizations and public agencies to improve efficiency and transparency of government transactions. However, most blockchain applications lack clear advantages over the conventional digital recording of information. In addition, our review highlights that blockchain applications in public sector governance are potentially vast, though in most instances, the existing applications have not extended much beyond limited-scale pilots. We conclude with a call for the construction of indexes of public sector implementations of blockchains, as none yet exist, as well as for additional research to understand why governments have not deployed blockchains more widely.
Modelling Interfaces in Thin-Film Photovoltaic Devices
Authors: Jones Michael D. K. , Dawson James A. , Campbell Stephen , Barrioz Vincent , Whalley Lucy D. , Qu Yongtao
Published: June 2022

Developing effective device architectures for energy technologies—such as solar cells, rechargeable batteries or fuel cells—does not only depend on the performance of a single material, but on the performance of multiple materials working together. A key part of this is understanding the behaviour at the interfaces between these materials. In the context of a solar cell, efficient charge transport across the interface is a pre-requisite for devices with high conversion efficiencies. There are several methods that can be used to simulate interfaces, each with an in-built set of approximations, limitations and length-scales. These methods range from those that consider only composition (e.g. data-driven approaches) to continuum device models (e.g. drift-diffusion models using the Poisson equation) and ab-initio atomistic models (developed using e.g. density functional theory). Here we present an introduction to interface models at various levels of theory, highlighting the capabilities and limitations of each. In addition, we discuss several of the various physical and chemical processes at a heterojunction interface, highlighting the complex nature of the problem and the challenges it presents for theory and simulation.
The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis
Authors: Hong Ru-ping , Hou Yue-ying , Xu Xin-jie , Lang Ji-dong , Jin Yun-feng , Zeng Xiao-feng , Zhang Xuan , Tian Geng , You Xin
Published: June 2022

Autism is a kind of biologically based neurodevelopmental condition, and the coexistence of atopic dermatitis (AD) is not uncommon. Given that the gut microbiota plays an important role in the development of both diseases, we aimed to explore the differences of gut microbiota and their correlations with urinary organic acids between autistic children with and without AD. We enrolled 61 autistic children including 36 with AD and 25 without AD. The gut microbiota was sequenced by metagenomic shotgun sequencing, and the diversity, compositions, and functional pathways were analyzed further. Urinary organic acids were assayed by gas chromatography–mass spectrometry, and univariate/multivariate analyses were applied. Spearman correlation analysis was conducted to explore their relationships. In our study, AD individuals had more prominent gastrointestinal disorders. The alpha diversity of the gut microbiota was lower in the AD group. LEfSe analysis showed a higher abundance of Anaerostipes caccae, Eubacterium hallii, and Bifidobacterium bifidum in AD individuals, with Akkermansia muciniphila, Roseburia intestinalis, Haemophilus parainfluenzae, and Rothia mucilaginosa in controls. Meanwhile, functional profiles showed that the pathway of lipid metabolism had a higher proportion in the AD group, and the pathway of xenobiotics biodegradation was abundant in controls. Among urinary organic acids, adipic acid, 3-hydroxyglutaric acid, tartaric acid, homovanillic acid, 2-hydroxyphenylacetic acid, aconitic acid, and 2-hydroxyhippuric acid were richer in the AD group. However, only adipic acid remained significant in the multivariate analysis (OR = 1.513, 95% CI [1.042, 2.198], P = 0.030). In the correlation analysis, Roseburia intestinalis had a negative correlation with aconitic acid (r = -0.14, P = 0.02), and the latter was positively correlated with adipic acid (r = 0.41, P = 0.006). Besides, the pathway of xenobiotics biodegradation seems to inversely correlate with adipic acid (r = -0.42, P = 0.18). The gut microbiota plays an important role in the development of AD in autistic children, and more well-designed studies are warranted to explore the underlying mechanism.
PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm
Authors: Shariati Aref , Chegini Zahra , Ghaznavi-Rad Ehsanollah , Zare Ehsan Nazarzadeh , Hosseini Seyed Mostafa
Published: June 2022

The biofilm community of microorganisms has been identified as the dominant mode of microbial growth in nature and a common characteristic of different microorganisms such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. The biofilm structure helps in the protection from environmental threats including host immune system and antimicrobial agents. Thus, the biofilm community has led to a higher prevalence of multidrug-resistant (MDR) strains in recent years. In this regard, the use of a new class of antibiotics, natural compounds, and anti-biofilm enzymes has been considered for the destruction of the microbial biofilm. However, different drawbacks such as low penetration, high susceptibility to degradation, instability, and poor solubility in aqueous solutions limit the use of anti-biofilm agents (ABAs) in a clinical setting. As such, recent studies have been using poly lactic-co-glycolic acid (PLGA)-based nanoplatforms (PLGA NPFs) for delivery of ABAs that have reported promising results. These particles, due to proper drug loading and release kinetics, could suppress microbial attachment, colonization, and biofilm formation for a long time. Additionally, PLGA NPFs, because of the high drug-loading efficiencies, hydrophilic surface, negative charge, and electrostatic interaction, lead to effective penetration of antibiotics to the deeper layer of the biofilm, thereby eliminating the microbial biofilm. Thus, PLGA NPFs could be considered as a potential candidate for coating catheters and other medical material surfaces for inhibition and destruction of the microbial biofilm. However, the exact interaction of PLGA NPFs and the microbial biofilm should be evaluated in animal studies. Additionally, a future goal will be to develop PLGA formulations as systems that can be used for the treatment of the MDR microbial biofilm, since the exact interactions of PLGA NPFs and these biofilm structures are not elucidated. In the present review article, we have discussed various aspects of PLGA usage for inhibition and destruction of the microbial biofilm along with different methods and procedures that have been used for improving PLGA NPF efficacy against the microbial biofilm.
Effect of Acupuncture on Blood Pressure and Metabolic Profile Among Patients With Essential Hypertension: Protocol of a Randomized Clinical Trial
Authors: Zhang Pan , Chen Yalan , Zhang Furong , Pei Hong , Sun Mingsheng , Qu Yuzhu , Chen Jiyao , Du Ting , He Xiaoguo , Liang Fanrong , Jia Weiguo , Yang Mingxiao
Published: June 2022

Essential hypertension is a polygenic cardiovascular disease that is associated with maladaptive metabolic changes. Acupuncture as a non-pharmacologic intervention is used to lower blood pressure and improve metabolic dysfunction. However, such effects have not been clinically characterized. We will conduct a randomized clinical trial to evaluate the antihypertensive effect of acupuncture among patients with essential hypertension and determine the associated metabolic improvements. This study is a phase II, two-arm, randomized, sham-controlled trial (Trial registration: ChiCTR2100043737), in which biospecimens will be collected for metabolic profiling. A total of 64 patients with a clinical diagnosis of essential hypertension will be randomly assigned to either the acupuncture or the sham acupuncture group in a 1:1 ratio. All participants will receive 10 treatments over 4 weeks, with three sessions per week for the first 2 weeks and two sessions per week for the remaining weeks. The primary outcome is the change of the systolic and diastolic blood pressure measured by the 24-h ambulatory blood pressure monitoring from baseline to 4 weeks. Secondary outcomes include the circadian rhythm of blood pressure, sleep quality measured by the Insomnia Severity Index, cognitive function measured by the Montreal Cognitive Assessment, and others. Fasting blood serum and urine samples will be collected at baseline and 4 weeks for targeted and untargeted metabolomics analysis. We will use the mixed-effects model and other related bioinformatics approaches to analyze the clinical and metabolome data. This metabolomic-based trial will provide important clinical data regarding the efficacy of acupuncture for essential hypertension to better inform evidence-based care delivery for hypertension patients. Moreover, the findings will offer important insights into the mechanism of action of acupuncture for hypertension by revealing its effect on metabolism. The results of this study will be used to inform the design of a statistically powered, multicenter, randomized trial. We will publish the study findings in peer-reviewed journals. The ethical approval of this study has been reviewed and approved by the Sichuan Regional Ethics Review Committee on Traditional Chinese Medicine (ID: 2021KL-006). The outcomes of the trial will be disseminated through peer-reviewed publications.
Long-Term Mortality After TAVI for Bicuspid vs. Tricuspid Aortic Stenosis: A Propensity-Matched Multicentre Cohort Study
Authors: Gasecka Aleksandra , Walczewski Michał , Witkowski Adam , Dabrowski Maciej , Huczek Zenon , Wilimski Radosław , Ochała Andrzej , Parma Radosław , Scisło Piotr , Rymuza Bartosz , Zbroński Karol , Szwed Piotr , Grygier Marek , Olasińska-Wiśniewska Anna , Jagielak Dariusz , Targoński Radosław , Opolski Grzegorz , Kochman Janusz
Published: June 2022

Objectives

Patients with bicuspid aortic valve (BAV) stenosis were excluded from the pivotal trials of transcatheter aortic valve implantation (TAVI). We compared the in-hospital and long-term outcomes between patients undergoing TAVI for bicuspid and tricuspid aortic valve (TAV) stenosis.

Methods

We performed a retrospective registry-based analysis on patients who underwent TAVI for BAV and TAV at five different centers between January 2009 and August 2017. The primary outcome was long-term all-cause mortality. Secondary outcomes were in-hospital mortality, procedural complications, and valve performance.

Results

Of 1,451 consecutive patients who underwent TAVI, two propensity-matched cohorts consisting of 130 patients with BAV and 390 patients with TAV were analyzed. All-cause mortality was comparable in both groups up to 10 years following TAVI (HR 1.09, 95% CI: 0.77–1.51). Device success and in-hospital mortality were comparable between the groups (96 vs. 95%, p = 0.554 and 2.3 vs. 2.1%, p = 0.863, respectively). Incidence of procedural complications was similar in both groups, with a trend toward a higher rate of stroke in patients with BAV (5 vs. 2%, p = 0.078). Incidence of moderate or severe paravalvular leak (PVL) at discharge was comparable in both groups (2 vs. 2%, p = 0.846). Among patients with BAV, all-cause mortality was similar in self-expanding and balloon-expandable prostheses (HR 1.02, 95% CI: 0.52–1.99) and lower in new-generation devices compared to old-generation valves (HR 0.27, 95% CI 0.12–0.62).

Conclusion

Patients who had undergone TAVI for BAV had comparable mortality to patients with TAV up to 10 years after the procedure. The device success, in-hospital mortality, procedural complications, and PVL rate were comparable between the groups. The high rate of neurological complications (5%) in patients with BAV warrants further investigation.
Can Outcomes of a Chat-Based Suicide Prevention Helpline Be Improved by Training Counselors in Motivational Interviewing? A Non-randomized Controlled Trial
Authors: Janssen Wilco , Raak Jeroen van , Lucht Yannick van der , Ballegooijen Wouter van , Mérelle Saskia
Published: June 2022

Objective

To examine whether the outcomes of a chat-based suicide-prevention helpline could be improved by training counselors in motivational interviewing (MI).

Methods

In a pre- and post-test design, visitors of a chat-based suicide prevention helpline received either the Five-Phase Model (treatment as usual [TAU]) or MI. They completed a pre- and post-chat questionnaire on several suicide-related risk factors. Linear mixed modeling was used to estimate the effect of the condition. Furthermore, the treatment proficiency of newly trained counselors was assessed using MI-Scope.

Results

A total of 756 visitors and 55 counselors were included in this study. The visitors showed an improvement in suicidal ideation and psychological risk factors after a chat conversation. However, there were no significant differences between the MI and TAU conditions (β = 0.03, 95% CI [−0.23–0.30], p = 0.80). The treatment integrity indices showed that the counselors mostly used MI-consistent techniques but were unable to strategically employ these techniques to evoke enough change talk.

Conclusions

MI and TAU led to comparable outcomes in a chat-based suicide prevention helpline. The effectiveness of MI might improve by intensifying or improving the training of counselors, keeping the process of engaging more concise or offering visitors multiple sessions of MI.