bluuebunny/crossref_metadata_2025 huggingface dataset:
When Polyarthritis Hits the Foot: Deciphering Hallux Rigidus, a Complex and Debilitating Affliction
Authors: Alami Reda El , Alaoui Ismail , Jalal Mekaoui , Mouncef Boufetal , Allah Bassir Rida , Kharmaz Mohammed , Lamrani Moulay Omar , Salah Berrada Mohammed
Published: October 2023

In this article entitled "When arthritis hits the foot: deciphering Hallux Rigidus, a complex and debilitating affliction", we take an in-depth look at the case of a patient suffering from Hallux Rigidus associated with rheumatoid arthritis. We began with an overview of the condition, highlighting its significant impact on patients' mobility and quality of life. The importance of this case study was emphasized, due to the inherent complexity of this condition. Our aim was to analyze this clinical case in detail, covering the mechanisms, manifestations, diagnoses, treatments and psychosocial aspects associated with this disease. Our literature review addressed various aspects, including the definition, epidemiology, risk factors, pathological mechanisms, clinical manifestations, differential diagnosis, imaging modalities and classification of Hallux Rigidus. Finally, we explored treatment options, highlighting the advantages and limitations of these approaches, and made proposals for future improvements. We have also highlighted the importance of patient psychosocial aspects in the overall management of this condition. In conclusion, our article offers a comprehensive overview of Hallux Rigidus, while highlighting the need for ongoing research to improve treatment and quality of life for patients affected by this complex condition.
Risk Factors for Hemorrhoids on Screening Proctoscopy at Rajshahi Medical College Hospital in Bangladesh: A Prospective Study
Authors: Uddin Md. Zalal , Sadik Md. Golam , Sarkar Md. Habibullah , Islam Md. Salek Bin , Kowsari Mst. Mosfika
Published: October 2023

Background: Hemorrhoids are a common medical condition that affects a significant portion of the population worldwide. Understanding the risk factors associated with hemorrhoids is crucial for effective prevention and management. This prospective study conducted at the Department of Surgery, Rajshahi Medical College Hospital in Bangladesh aimed to identify and analyze the risk factors for hemorrhoids in a sample of 156 patients over a three-year period from June 2017 to June 2020. Methods: A total of 156 patients who presented with symptoms suggestive of hemorrhoids underwent screening proctoscopy at Rajshahi Medical College Hospital. Data on demographic variables, lifestyle factors, medical history, and dietary habits were collected through structured interviews and medical records review. Statistical analysis, including logistic regression, was employed to identify significant risk factors associated with the development of hemorrhoids. Results: The study revealed several key risk factors associated with hemorrhoids, including age, gender, family history, dietary habits, and sedentary lifestyle. Logistic regression analysis identified age over 40 years (OR=2.58, 95% CI: 1.34-4.97), male gender (OR=1.92, 95% CI: 1.07-3.44), positive family history of hemorrhoids (OR=2.14, 95% CI: 1.18-3.86), low fiber diet (OR=2.36, 95% CI: 1.27-4.40), and prolonged sitting (OR=1.78, 95% CI: 1.02-3.10) as significant risk factors for hemorrhoids. Conclusion: This prospective study conducted at Rajshahi Medical College Hospital in Bangladesh provides valuable insights into the risk factors associated with hemorrhoids in the study population. The findings underscore the importance of lifestyle modifications and early intervention strategies to reduce the burden of this common medical condition in Bangladesh.
Review of Surgical Activities in the Tominian Health District
Authors: S Dembélé, K. , I, Diarra, , K Malle, , S Konate, , A Dembele, , H Dolo, , M, Keita, , A Traore, , M Coulibaly, , D Fomba, , D Kanthe, , A Diarra, M. , , S Camara, , B Traore, , Z Dao, S. , D Cisse, , A Dicko, O. A.
Published: October 2023

Objective: To establish an assessment of surgical activities at the Tominian Reference Health Center. Method: This was a prospective descriptive study covering all patients received and operated on at the Tominian Reference Health Center over a period of 8 months from October 1, 2022 to May 2023; Results: We operated on 247 patients, including 64% (157 patients) in emergencies. The mean age was 35.6 ± 2.8 years with extremes of 2 and 57 years. Emergency cesarean section represented 49% (121 patients). Genital prolapse represented 13% (31 patients), hernias represented 11% (28 cases); acute peritonitis represented 5% (13 cases), intestinal obstruction 3% (7 cases). Benign prostatic hypertrophy (11 cases), uterine myomas (8 cases), uterine rupture (11 cases), splenectomy (2 cases), TAF (3 cases) and VVF (2 cases). We recorded 4 cases of death. Conclusion: Surgical pathologies remain frequent and diversified in rural areas, the need for qualified personnel in general and in surgical specialties in particular remains necessary to improve health coverage, especially for obstetric emergencies.
Multi-Tasking and Administrative Service Delivery in Rubirizi District in Western Uganda
Authors: Deusdedit Byabashaija , Enos Rwasheema , Paul Musoke
Published: October 2023

The realistic study evaluated the relationship between Multi-Tasking and Administrative Service Delivery in Rubirizi District in western Uganda. The research study applied a survey descriptive autopsy design with a quantitative paradigm. A sample of 72 respondents were carefully chosen from 155 persons using Slovene’s formula. Information was congregated by means of questionnaires. The researchers used simple and stratified random sampling techniques to garner data from the field. Data was appraised using Descriptive statistics such as Pie charts and Pearson linear correlation coefficient (PLCC) for quantitative measurements. The study outcomes came up with a significant relationship between Multi-Tasking and Administrative Service Delivery in Rubirizi District in Western Uganda. The research project team concluded that doing more than one task at a time, especially more than one complex task, takes a toll on productivity. Managers can achieve their targets well if multi-tasking is well planned for and well implemented in any organization. From the study verdicts, the academics recommended that Managers should continue to apply multi –tasking techniques in order to reduce on the costs of their organizations. An employee can be given more tasks to perform which would have otherwise been done by many workers, thus saving on the expenses of the organization. Managers should try by all means to motivate the workers who perform many tasks in order to encourage them do their work efficiently. However, Multi-tasking with complex tasks should be avoided for example driving and receiving a phone call which may be a major cause of death among mankind.
A Novel Technique of Management of Impacted VUJ Calculus: Laparoscopic Ureterotomy
Authors: Save Dr Maitreyee M , Dalvi Dr Aditi V , Kothari Dr Paras R , Kulkarni Dr Apoorva A
Published: October 2023

The incidence of urolithiasis in the pediatric population is on the rise. Endoscopic lithotripsy has become a technique of choice for the treatment of ureteral stones in children. Laparoscopic ureterolithotomy is a minimally invasive option for ureteric stones that are not amenable to ureteroscopy. We present a case of 7 years girl with right impacted vesicoureteric junction (VUJ) calculus with bullous cystitis managed innovatively with laparoscopic ureterotomy.
Differential Diagnosis between Parapyelic Cyst and Pyeloureteral Junction: A Clinical Case Study
Authors: Benabdallah Y. Staouni , Garrab M. , Sabbagh R. Al , Aboutaeib R.
Published: October 2023

Objectives: Intra-sinus renal cysts or parapyelic cysts represent a rare form of renal cysts. They are often associated with lower back pain. Symptomatic cases can be treated with percutaneous puncture and sclerotherapy, but due to the proximity to the renal hilum, the treatment of these cysts has undergone significant changes. Thus, percutaneous treatment has become contraindicated due to the potential for complications. While laparoscopic treatment appears to be the most suitable and effective technique, open surgery still has its indications, especially for large cysts and cases where there is diagnostic uncertainty along with an associated junction abnormality, as is the case in our study. Patients and Methods: We report a case of a right parapyelic cyst revealed by acute right pyelonephritis, with a diagnostic scan suggesting pyeloureteral junction syndrome secondary to a subpyelic crossing with an 8 cm parapyelic cyst, with contrast material passing into the cyst. Due to diagnostic uncertainty and operative difficulties under laparoscopy, a right lumbotomy was performed, allowing for the resection of an 8 cm parapyelic cyst and confirming the absence of an associated junction abnormality, without intraoperative complications. Results: 450 cc of citrine yellow fluid was recovered, with a permeable junction and absence of the lower polar vessel. Postoperative evolution was favorable both medically and surgically, with removal of the urinary catheter and JJ stent on postoperative day 5. Conclusion: Surgical treatment of parapyelic cysts through lumbotomy remains of interest as an effective approach, especially in cases of diagnostic uncertainty, with low morbidity and a short convalescence period.
A New Member in the Lindley Class of Distributions with Flexible Applications
Authors: Oramulu Dorathy O. , Etaga Harrison O. , Onuorah Azubuike J. , Obulezi Okechukwu J.
Published: October 2023

In this paper, a new lifetime distribution in the class of Lindley is developed and it is called "Doje Distribution". It is flexible in modeling lifetime data. The mathematical properties which include moments, the shape of the distribution, Quantile function, hazard function, survival function, stochastic ordering, mean deviation, Bonferroni and Lorenz curve, order statistic, and Renyi entropy have been studied. The maximum likelihood estimation has also been discussed. Two-lifetime data sets were utilized to demonstrate its usefulness. The results show that the proposed Doje distribution is better than Lindley, Ishita, Pareto, Chris-Jerry, Sushila, and Rama’s distribution in the instances of the data used.
New Insights for Plant Genome Optimization, Biotic and Abiotic Stresses and Agricultural Applications
Authors: Shabir Muzamil , Amjad Zunaira , Jalal Ahmer , Zulekha Zulekha , Fatima Iqra , Yousaf Khizra , Nabi Muhammad Mutie Un , Khalil Arij
Published: October 2023

Plant genomics experienced a revolution as a result of the cheap cost and simplicity of sequencing, which produced numerous assemblies of inferior quality but also a sharp rise in the number of revolutionary genome-enabled discoveries concerning the basic plant biology. Crops physiological, metabolic, and molecular responses to several abiotic challenges appear to be very different from their reactions to single stresses. One of the most crucial fields of plant research is the investigation of the processes underlying plant adaptation to environmental stresses. As biological messengers that control gene expression, ROS and NO work synergistically to activate defense mechanisms in response to biotic and abiotic stresses. It is known that S-nitrosoglutathione reductase (GSNOR), which is thought to be a key regulator of plant stress tolerance due to its effect on protein S-nitrosylation, contributes to Solanum lycopersicum's thermotolerance. Vitamin K3, often known as pro-vitamin K, has an addition component called menadione sodium bisulphite (MSB). In contrast, CRISPR/Cas9 can speed up the plant breeding by quickly, precisely, and predictably altering genomes. CRISPR/Cas9 has recently gained popularity as a technique for genome editing and has been extensively utilized in crop resistance breeding because to its effectiveness, simplicity, and adaptability.
The Inlfuence of Internal Control on Good Corporate Governance in Pt Pos Indonesia (Persero) Bandung City
Authors: Salsabila Azka
Published: October 2023

This study aims to determine the effect of internal control on good corporate governance. The factors tested in this study are the independent variable is internal control, while the dependent variable is good corporate governance. The research method used is the verification method. The population in this study is the internal auditor at the Internal Supervisory Unit (SPI) at PT Pos Indonesia (Persero) Bandung City, amounting to 36 employees. The sampling technique used is a non-probability sampling technique with a total sampling technique, so that the number of samples is 36 employees. The analytical method used is simple linear regression analysis using the SPSS Version 25.00 program. The results of the study indicate that internal control and good corporate governance are included in the fairly good category. In addition, the results of hypothesis testing show that internal control has an effect on good corporate governance at PT Pos Indonesia (Persero) Bandung City. The magnitude of the influence of internal control in contributing to the influence of good corporate governance is 44.9%.
Financial Shenanigans in the Perspective of the Hexagon Theory
Authors: Nurbaiti Annisa , Ferdiawan Ryan Ramadhan
Published: October 2023

Financial Shenanigans are the actions of a person or group in a company by deliberately manipulating the company's financial statements to mislead users of financial statements, one of which is investors. This study aims to see the partial influence of Hexagon Theory on financial shenanigans. The sample of this research is companies in the primary consumer goods sector that are listed on the Indonesia Stock Exchange in 2017-2021. The sampling technique used was non-probability sampling and purposive sampling in order to obtain a total of 160 samples from 32 companies in the primary consumer goods sector. The analytical method used is analysis logistic regression and using SPSS 25 software. Based on the results of the entire series of studies conducted, researchers can conclude that, the opportunity variable proxied by the whistleblowing system, the rationalization variable proxied by auditor turnover and the collusion variable proxied by audit fees have no effect on financial shenanigans. Then the variable pressure is proxied by personal financial needs, the variable capability is proxied by the change of directors, arrogance is proxied by the frequency of CEO photos, and has an influence on financial shenanigans. Future research is expected to broaden the scope of data that is the object of research and it is suggested to further test other proxies that represent the Hexagon Theory factors, especially the rationalization, arrogance, and collusion factors and conduct further research on the collusion factor proxied by the audit fee so as to find the results maximum research.
Fundamental Analysis in Investment Decision Making on the Indonesia Stock Exchange Accelerated Board
Authors: Afifah Nurul , Sari Maya , Dewi Andrieta Shintia , Arfiansyah Ferry
Published: October 2023

Fundamental analysis is one of the considerations for investors to invest in a company. The study aims to identify the appropriate investment choices for companies listed on the Indonesian Stock Exchange accelerated board. By calculating, examining, and deriving inferences from the financial records of the sample organizations, this research employs a quantitative descriptive technique. Three companies in the acceleration board that meet specified criteria make up the research sample. The research data is in the form of financial reports for the three years from 2019 to 2021. The results show that PT Panca Anugrah Wisesa Tbk. has the greatest average ROA, PT Prima Globalindo Logistik Tbk has the highest average CR, PT Prima Globalindo Logistik Tbk k. Offers the highest average DAR value, and the highest average TATO value at PT Prima Globalindo Logistik Tbk. Based on these findings, it is possible to infer that the best investment decision in PT Prima Globalindo Logistik Tbk.
Effect of Management Ownership, Industry Auditor Specialization, Audit Complexity and Auditor Switching on Timeliness of Financial Reporting
Authors: Triyanto Dedik Nur , Farida Ajeng Luthfiyatul , Permata Namira
Published: October 2023

This study aims to determine the effect of managerial ownership, auditor industry specialization, complexity audit, and auditor switching on the timeliness of submitting financial reports to Energy sector companies listed on the Indonesia Stock Exchange in 2017-2021. The method in this research is a quantitative research method. The population in this study are energy sector companies listed on the Indonesia Stock Exchange during 2017-2020. The sampling technique in this study used a purposive sampling technique with 41 research samples within five years so that a total of 205 research data were obtained. Data analysis used descriptive statistical analysis method and logistic regression analysis using SPSS 26 software. The results showed that managerial ownership, auditor industry specialization, audit complexity had a positive effect on the timeliness of financial reporting, while switching auditors did not affect on the timeliness of financial reporting. The accuracy of submitting financial statements to companies tends to be influenced by factors such as high levels of managerial ownership, auditor industry specialization, and audit complexity, but the presence of switching auditors in the company does not affect the time of submission of financial statements.
The Effect of Good Corporate Governance and Auditor Performance on Audit Quality with Integrity as a Moderating Variable
Authors: Sahidah Sahidah , Putra Robiur Rahmat , Julito Kiko Armenita
Published: October 2023

Good Corporate Governance or corporate govenance is a company’s effort to create a pattern of conducive ralationships between steakeholders in a company. Because a conducive relationship between these stakeholders is a prerequisite in realizing maximum company performance to support increasing company value. With the statement above, it is clear thah corporate governance is closely related to the value of a company and of course also closely related to financial performance within the company. This research goals to examine the effect of Good Corporate Governance and auditor performance on audit quality, with integrity as a moderating variable. The sample selection technique used in this study was a purposive sampling technique with 100 samples. The data collection method used is a questionnaire, by distributing questionnaires in public accounting firms (KAP). The data analysis technique used to test the hypothesis in research is Partial Least Square (PLS) analysis, which is a Structural Equation Modeling (SEM) equation model with a variance approach or a component-based structural equation model. The results of the study show that good corporate governance, auditor performance influences audit quality. And also shows that integrity is able to moderate the performance of the auditor, which will affect audit quality. On the other hand, the research results show that integrity does not moderate Good Corporate Governance on audit quality.
Increasing Company Value: The Role of Profitability and Capital Structureand Tax Avoidance as Mediation
Authors: Sari Diana , Mulyati Yati , Purnamasari Dyah
Published: October 2023

Firm value is an important factor in the view of investors as well as a form of success for managers in managing the company. In addition to success for managers, company value can also have an impact on increasing stock prices. The purpose of this study is to see how the influence of capital structure, profitability and tax avoidance on firm value. The samples selected in this study were 59 technology sector companies listed on the Stock Exchange and the Singapore Stock Exchange for the period 2017 to 2022. The sampling technique used in this study was to use side non-probability using a purposive sampling method. Data analysis in this study uses path analysis with the help of Smart-PLS software to test the proposed model. The results of this study indicate that the three variables consisting of capital structure, profitability and tax avoidance have a significant positive effect on firm value. Likewise, the role of tax avoidance was found to be a variable that mediates between capital structure and profitability on firm value.
The Influence of Total Quality Management (TQM) and Characteristics of Management Accountig Information Systems on Managerial Performance
Authors: Januarty Tamy Ali , Sundari Siti Asyiah
Published: October 2023

Managerial performance is one of the things that can drive the success of a company's goals. There are several things that can affect and improve managerial performance including total quality management and management accounting information systems. The application of total quality management will help the managerial role to further improve its performance so that it can be carried out properly. In addition, the existence of an available management accounting information system will support the control and decision-making process of a manager. This study aims to determine the effect of total quality management and the characteristics of management accounting information systems on managerial performance at PT. So Good Food Jakarta Branch. Application of total quality management and management accounting information systems at PT. The So Good Food Jakarta Branch has been running and is well available, but there needs to be improvement so that the implementation of total quality management and management accounting information systems can run optimally. The method in this study was to conduct a questionnaire survey with an ordinal scale form to 40 respondents from PT. So Good Food Jakarta Branch, then data processing is carried out using SEM-PLS data analysis techniques and is designed with a quantitative approach to descriptive analysis and verification. The results of this study are expected to be a solution to problems related to managerial performance at PT. So Good Food Jakarta Branch.

The results of this study prove that: (1) total quality management has an effect on managerial performance, (2) the characteristics of management accounting information systems have an effect on managerial performance
Changes in immunity during the second trimester of pregnancy in women with exacerbation of bronchial asthma associated with reactivation of cytomegalovirus infection
Authors: Odireev A. N. , Gorikov I. N. , Nakhamchen L. G. , Andrievskaya I. A. , Ishutina N. A. , Prokopenko A. V.
Published: October 2023

Aim. To evaluate changes in immunity in the second trimester of pregnancy in women with exacerbation of bronchial asthma associated with reactivation of cytomegalovirus infection (CMVI).

Materials and methods. The concentration of secretory immunoglobulin A (sIgA), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM) and circulating immune complexes (CIC) was studied in 112 women at 21-24 weeks of uncomplicated pregnancy and pregnancy complicated by exacerbation of mild-to-moderate asthma associated with CMVI. The first group included 30 women seronegative for CMV, with an uncomplicated pregnancy. The second group consisted of 30 patients with exacerbation of mild asthma, initiated by the acute phase of CMVI, which induces the development of chronic compensated placental insufficiency. The third group consisted of 27 patients with moderate asthma in the acute stage against the background of the acute phase of CMVI, leading to the formation of chronic compensated placental insufficiency. The fourth group included 25 patients with exacerbation of moderate asthma with CMV etiology, initiating the development of chronic subcompensated placental insufficiency.

Results. In women of the second group, the concentration of sIgA was 5.91±0.371 mg/L, IgA – 2.64±0.089 mg/mL, IgG – 15.4±0.791 mg/mL, IgM – 2.32±0.144 mg/mL, CIC – 0.176±0.004 optical density units (in the first group, respectively, 4.31±0.266 mg/L, p<0.001; 2.37±0.06 mg/mL, p<0.05; 13.3±0.293 mg/mL, p<0,05; 1.11±0.06 mg/mL, p<0.001; 0.092±0.005 optical density units, p<0.001). In patients of the third group, in contrast to the second one, no differences in immunity parameters were detected. In the fourth group, in comparison with the third one, lower parameters of sIgA (3.21±0.213 mg/L, p<0.001), IgA (1.43±0.081 mg/mL, p<0.001), as well as higher IgG values were detected (19.8±0.418 mg/mL, p<0.001), IgM (2.94±0.082 mg/mL, p<0.01) and CIC (0.198±0.005 optical density units, p<0.05).

Conclusion. In patients with moderate asthma with exacerbation against the background of CMVI reactivation, which initiates the formation of chronic subcompensated placental insufficiency, in contrast to women with moderate asthma in the stage of CMVI exacerbation in the second trimester of pregnancy, leading to chronic compensated placental insufficiency in the third trimester of gestation, a more pronounced imbalance of humoral immunity and autoimmune disorders are found, which are important in the development of chronic placental dysfunction.
Dose-dependent effect of ethanolamine of eicosapentaenoic acid on the synthesis of oxylipins by blood cells of patients with bronchial asthma in vitro
Authors: Kovalenko I. S. , Bocharova N. V. , Novgorodtseva T. P. , Denisenko Yu. K.
Published: October 2023

Introduction. The search for new highly effective methods for the treatment and control of bronchial asthma is an urgent task in pathophysiology and pharmacology. A promising substance for the regulation of systemic chronic inflammation is N-acylethanolamine (EPEA) of eicosapentaenoic acid, which exhibits immunoregulatory properties.

Aim. To study the dose-dependent effect of eicosapentaenoic acid ethanolamine on the synthesis and metabolism of oxylipins by blood cells in patients with asthma under in vitro conditions.

Materials and methods. The object of the study was the whole blood of 5 patients with controlled mild-to-moderate asthma and 6 healthy people. The in vitro experiment was carried out in lipopolysaccharide-stimulated blood after incubation for 30 minutes. Then the experimental substance N-acyl-ethanolamine of eicosapentaenoic acid (NAE 20:5) was added at concentrations of 1.0, 5.0 and 10.0 µM and incubated at 37ºC for 6 hours in gentle mixing mode. The level of oxylipins was studied by enzyme immunoassay.

Results. Experimental exposure to N-acylethanolamines of eicosapentenoic acid had the following effects. Under the influence of ethanolamine of eicosapentaenoic acid at a concentration of 1 µM, the level of PGE2 decreased by 51% (p<0.001) and the amount of 15-HEPE increased by 32% (p<0.05) in lipopolysaccharide-induced blood plasma relative to the values before exposure to ethanolamine. Also EPEA at this dosage showed a tendency to increase the level of 18HEPE. Exposure to EPEA at 5µM resulted in a significant decrease in LTB4 levels by 34% (p<0.001), PGE2 levels by 51% (p<0.001), as well as an increase in 12-HEPE levels by 33% (p<0.01), 15-HEPE by 36% (p<0.05) and 18-HEPE by 87% (p<0.01). Under the influence of EPEA at a dosage of 10 µM, a statistically significant effect on the entire spectrum of the studied oxylipins was revealed. Thus, the use of this dose of ethanolamide in LPS-induced blood showed a decrease in the concentration of LTB4 by 37% (p<0.001), LXA4 by 22% (p<0.05), PGE2 by 50% (p<0.001) and an increase in 5HEPE concentration by 25% (p<0.05), 12-HEPE by 76% (p<0.001), 15-HEPE by 75% (p<0.001), 18-HEPE by 155% (p<0.001) relative to pre-EPEA values.

Conclusion. Further study of NAE fatty acids opens up new perspectives in the study of targeted methods for correcting the inflammatory response in bronchial asthma.
The effect of TRPV1 gene polymorphism on the development of progressive course of chronic obstructive pulmonary disease
Authors: Gassan D. A. , Naumov D. E. , Kotova O. O. , Sugaylo I. Yu. , Sheludko E. G. , Afanas’eva E. Yu. , Gorchakova Y. G.
Published: October 2023

Introduction. It is known that the course of chronic obstructive pulmonary disease (COPD) may vary depending on the rate of bronchial obstruction progression. It has been shown that TRPV1 channels play an important role in the formation of some pathological syndromes typical for COPD.

Aim. To study the effect of single nucleotide polymorphisms (SNPs) of TRPV1 gene on the rate of bronchial obstruction progression in COPD patients.

Materials and methods. We examined 103 patients with COPD, including 47 with rapid progression of bronchial obstruction (decrease in FEV1≥50 ml/year). SNPs rs460716, rs222749, rs222747, and rs8065080 were genotyped by LATE-PCR.

Results. We established that rs460716 SNP had a significant effect on the development of progressive bronchial obstruction in COPD. The CC+TT genotypes were more common among patients with progressive disease (48.9% versus 23.2%), while the heterozygous genotype was protective (p=0.006). Differences remained significant after adjusting for sex, age, pack-year index and baseline FEV1 (OR 3.2; 95%CI [1.32; 7.57], p=0.009).

Conclusion. The obtained results indicate a negative influence of the homozygous genotypes carriage for TRPV1 rs460716 SNP on the course of COPD.
Isolation of a rare pathogen Chryseobacterium indologenes in patients with pneumonia
Authors: Golubeva A. O. , Bondarenko A. P. , Natykan Yu. A. , Trotsenko O. E. , Kurganova O. P. , Pshenichnaya N. Yu. , Taran E. K.
Published: October 2023

Introduction.Chryseobacterium indologenesbacteria are rarely detected, poorly studied opportunistic bacteria of the nonfermenting gram-negative bacilli group that are characterized by high intrinsic and acquired multidrug resistance and involvement in healthcare associated infections.

Aim.To analyze detection rate ofC. indologenesstrains from various biomaterials obtained from patients with pneumonia, as well as levels of pathogen drug resistance to antimicrobial drugs.

Materials and methods.The research included 1740 clinical samples obtained from patients with pneumonia hospitalized in in-patient facilities of the Khabarovsk city during the COVID-19 pandemic. Clinical samples included 1305 respiratory samples (744 sputum samples and 561 nasopharyngeal swabs), 435 samples of autopsy material (lung tissue) obtained from patients with a fatal outcome of the disease. The study was performed via classical bacteriological method. Pathogens were identified with Vitek 2 bacteriological analyzer and Vitek MS mass spectrometer. Sensitivity to antimicrobial drugs was determined by disk-diffusion method and in a bacteriological analyzer.

Results.A comparative analysis of detection of the entire nonfermenting gram-negative bacteria (NFGNB) group andC. indologenesfrom various clinical samples was carried out. Detection rate of NFGNB equaled 17.3%. NFGNB were isolated from autopsy material most often ‒ in 31.7% of cases, less often ‒ from sputum and nasopharyngeal smears (13.8% and 10.7%, respectively).C. indologeneswas detected in 0.5% of the cases (8 isolates out of 1740 samples). Isolation of this pathogen was most frequent in nasopharyngeal smears – in 1.1% (6 cases out of 561 samples), least frequent ‒ from sputum, which totaled 0.3% (2 isolates from 744 samples). The detection rate of the pathogen in respiratory samples equaled 0.6% (8 isolates out of 1305 samples). This pathogen was not found in the autopsy material. Carbapenem-resistant variants ofC. indologeneswere isolated in 75% (6 cases out of 8) of the cases.

Conclusion.Further intensifying of diagnostic methods will result in more frequent detection of these unusual pathogens, clinical significance of which needs more justification.
Assessment of Stakeholder Involvement and Borehole Water Projects Delivery in Kogi West Senatorial District, Nigeria
Authors: Adepoju Adeyemi , Obademi Tokunboh
Published: October 2023

There is huge challenges in the supply of clean water for household consumption in many countries, in particular, Nigeria. Kogi West Senatorial District (KWSD) has witnessed more borehole projects in Nigeria but the challenge of clean water still persists. This has necessitated more research into the field of water resources to combat such challenges in line with the sustainable development goals (SDGs). This study assessed the effects of stakeholders’ involvement in KWSD, Nigeria, with a view to improving the delivery of borehole water projects in the study area. Data were collected through a structured questionnaire from 267 stakeholders comprising Lower Niger River Basin Development Authority (LNRBDA) staff, community leaders and community members that were selected using simple random sampling technique. The study objective was assessed with inferential statistics (Partial Least Square in Structural Equation Modelling). The results disclose the direct path coefficients for Initiation stage (bIS), Planning stage (bPS), Execution stage (“bES”), Monitoring and closure stage (bMS), Post construction stage (bPCS), Budget (cBG), Time Delivery (cTD) and Stakeholder’s Satisfaction (cSS). The results illustrated positives and significant relationship with bES -> cBG (β = 0.422, t = 5.708), bES -> cSS (β = 0.495, t = 6.366), bES -> cTD (β = 0.493, t = 7.422), bMS -> cBG (β = 0.164, t = 2.643), bPCS -> cTD (β = 0.257, t = 5.7084.440), and negative significant relationship with bMS -> cTD  (β = -0.184, t = 2.547) and  bPS -> cSS (β = - 0.182, t = 2.586). The study concludes that stakeholders’ involvement is a strong predictor of viable Borehole water projects delivery in the study area.
Assessment of the efficiency of production processes based on the value flow map
Authors:   Jumasheva B.K. Akimov S.S. Borovskiy A.S.
Published: October 2023

A value flow map is developed for JSC Drilling Equipment Plant. The production bay for the production of a drill pipe is considered, all operations of the production process are studied, a map of the current state is built, which is optimized to increase the efficiency of the enterprise.

Keywords
value flow map, lean manufacturing, manufacturing process
Solar photometric system for indirect measurement of the optical thickness for the surface layer of atmospheric aerosol
Authors:   Suleymanova E.D.
Published: October 2023

The possibility of using solar photometers for indirect measurement of the optical depth of surface aerosol is studied. The proposed method and the corresponding technique for indirect measurement of the optical depth of surface aerosol using solar photometers are theoretically substantiated. Two methods of indirect measurements are proposed. The first method makes it possible to determine the increase in the optical depth of surface aerosol with a single-channel solar photometer by performing two-stage indirect measurements. The second method allows to determine the increment of ground aerosol using a two-channel solar photometer with identical channels. An invariant that makes it possible to verify the accuracy of the obtained measurement data at proposed methods sharing is obtained.

Keywords
surface aerosol, photometer, optical depth, indirect measurements, surface layer of the troposphere
Subpixel multiplicative method for detecting the threshold level of oil pollution in partially vegetated soil
Authors:   Azizova A.E.
Published: October 2023

The article is devoted to the issues of detecting the threshold level of contamination of partially vegetated soil. A multiplicative method for detecting soil contamination with hydrocarbons in the format of one pixel is proposed. Geometric averaging of the results of measuring the amount of hydrocarbons in the leaves, crown of vegetation and oil on the uncovered part of the site allows us to calculate the degree of contamination. The sensitivity of the meter was maximum during the measurement. Taking into account the specified threshold level of soil contamination, the device rebuilds its parameters so that the calculated and specified contamination indicators coincide. This allows you to detect areas with a threshold level of contamination with maximum sensitivity. This parameter is necessary to reliably determine the boundaries of soil contamination at a given threshold level.

Keywords
soil, threshold pollution level, geometric averaging, sensitivity, subpixel measurement
Open Learning, Distance Education with reference to General and Special Education and inclusive education
Authors: TIWARI DR PRAKASH NARAYAN
Published: October 2023

Open learning and distance education have grown as transformative tools in the field of education. These techniques enable learners in a range of settings, including general and special education, with possibilities that are adaptable and inclusive. the notions of open learning, remote education, and inclusive education, with an emphasis on the roles these ideas play in facilitating access, equity, and the provision of a high-quality education for all students. It studies the underlying tenets and practises of diverse educational approaches, concentrating specifically on how they meet the requirements of a wide spectrum of pupils, including those who have physical or mental impairments. the potential benefits and problems involved with implementing inclusive education approaches through open and remote learning, with the final focus being placed on the critical role that technology and educator support play in developing an inclusive and empowering learning environment.
Caries Dental en relación con el Índice de Masa Corporal en Escolares de Cd. México
Authors: Cortés Quiroz María Del Carmen , Valdez Penagos Remedios Guadalupe , Romo Pinales María Rebeca
Published: October 2023

Introducción. La caries dental y la obesidad en niños son patologías frecuentes en México y se desea conocer si existe una relación entre ellas dado que comparten el mismo factor de riesgo que es una alimentación inadecuada.

Objetivo. Determinar la relación entre la caries dental y el Índice de masa corporal en escolares de 6 a 11 años en una zona del oriente de la Ciudad de México.

Métodos. Estudio observacional transversal en muestra no probabilística de 626 escolares. Se realizó un examen dental, medición de peso en kilogramos y estatura en metros. Se estimaron los índices cpod, CPOD e IMC mediante los códigos y criterios que recomienda la Organización Mundial de la Salud, para analizar la relación entre la caries dental con el sobrepeso y la obesidad.

Resultados. Las prevalencias observadas fueron del 91% de caries dental y 14.5% de sobrepeso y obesidad. En el grupo masculino los valores más altos de los índices CPOD = 3.84 y 2.67 fueron para el sobrepeso y obesidad respectivamente y el cpod = 4.80 y 3.22 para los pesos bajo y medio. En el grupo femenino el valor más alto del CPOD = 3.18 fue para el nivel de obesidad.  

Discusión y conclusiones. Existe relación estadística entre el índice CPOD y el IMC en los dos grupos. La relación con el índice cpod se presentó solamente en el grupo masculino. Los resultados aportan información importante para orientar programas de promoción y educación en salud que generen hábitos saludables en los niños.
FACTORES DE RIESGO ASOCIADOS A ERC EN ETAPAS INCIPIENTES EN PACIENTES ADOLESCENTES, ATENDIDOS EN EL HOSPITAL GENERAL DE TLAXCALA 2019-2021
Authors: Orozco González Claudia Nelly , Ávila Rodríguez Antonieta Concepción , Sánchez Flores Héctor Manuel
Published: October 2023

Introducción: La prevalencia de enfermedad renal crónica está en aumento en adolescentes. Estos pacientes representan un desafío para la salud pública ya que se disminuye su calidad de vida y se aumentan los gastos en salud.

Objetivo: Determinar la prevalencia y los factores de riesgo asociados a ERC en etapas incipientes en pacientes adolescentes, atendidos en el Hospital General de Tlaxcala, en el periodo de enero de 2019 a junio de 2021.

Material y métodos: Se realizó un estudio analítico de casos y controles, en el Hospital General de Tlaxcala. Los casos tenían diagnóstico de ERC y los controles sin el diagnostico de ERC.

Resultados: En la comparación de casos y controles los casos tenían estadísticamente mayor presencia de diabetes (75% vs 34%), hipertensión arterial (91% vs 22%), exposición a aminoglucósido (59% vs 12%), además de vivir cerca de ríos (56% vs 19%), fábricas (66% vs 22%) y materiales pesados (59% vs 9%).

Conclusiones: La prevalencia fue de 6 pacientes con la enfermedad por cada mil atenciones durante el periodo del estudio. Las variables asociadas a la ERC fueron la menor talla, el mayor IMC, vivir expuestos a ríos, canales, fábricas y metales pesados, así como aminoglucósidos.
Eficacia de los bacteriófagos para el tratamiento de infecciones recalcitrantes
Authors: Talavera Juan Martín , Talavera-Rojas Martín , Reyes-Rodríguez Nydia Edith , Vega-Sánchez Vicente
Published: October 2023

Resumen

Con el surgimiento de β-lactamasas de espectro extendido (BLEE) y cepas bacterianas resistentes a múltiples fármacos existe una necesidad médica urgente para el tratamiento eficaz de múltiples infecciones de origen bacteriano. Los bacteriófagos, desde su descubrimiento a principios del siglo XX, fueron reconocidos como una propuesta terapéutica para enfrentar infecciones generadas por bacterias; algunos gobiernos y compañías farmacéuticas comienzan a reevaluar el uso terapéutico de estos “comedores de bacterias”. Sin embargo, existe poca revisión bibliográfica sobre la aplicación clínica de los fagos. En este trabajo, se revisan algunos informes modernos de la aplicación de la terapia fágica para el tratamiento exitoso de infecciones ocasionadas por bacterias formadoras de biopelículas en las que la terapia con antibióticos ha fallado. También se mencionan empresas e institutos internacionales que comercializan, investigan y desarrollan productos con fagos para uso humano. La terapia con fagos ofrece una alternativa prometedora para combatir las bacterias multirresistentes y reducir las infecciones letales. Los nuevos conocimientos sobre la seguridad y la eficacia de los fagos son cruciales para comprender mejor su aplicación.
Lidocaína: Anestésico local. Revisión bibliográfica
Authors: Alcántara Monroy Lizeth , Cordero López Valeria Monserrat , Benítez Martínez Ana Karen , Fuentes Corona Nancy Brigitte , Velázquez Zepeda Aldo
Published: October 2023

Los anestésicos son un grupo de fármacos empleados para disminuir la sensibilidad y la conciencia dado que bloquean la percepción del dolor. Los anestésicos se dividen en generales y locales, a su vez los locales se subdividen en amidas y ésteres. La lidocaína es un anestésico local perteneciente al grupo de las amidas que se utiliza principalmente en la anestesia local y analgesia posoperatoria. Por lo anterior y su importancia clínica, el presente artículo de revisión es una recopilación bibliográfica acerca de la lidocaína, sus propiedades químicas, mecanismo de acción, metabolismo, excreción, comparación con otros anestésicos, efectos adversos y toxicología.
Die Schweiz im europäischen und internationalen zivilprozessualen Rechtsraum - Stand und Perspektiven
Authors: Trüten Dirk
Published: October 2023

Voraussichtlich im Jahr 2025 wird die Schweiz dem Haager Übereinkommen über Gerichtsstandsvereinbarungen (HGÜ) beitreten. Dadurch wird das schweizerische Internationale Zivilprozessrecht zwar nicht grundlegend verändert, aber doch in einigen Punkten ergänzt und modernisiert. Der vorliegende Beitrag beleuchtet das HGÜ in seinem nationalen, europäischen und internationalen Regelungsumfeld und hebt hervor, dass es sich nicht um ein isoliertes Übereinkommen, sondern einen wichtigen Baustein im gerade entstehenden „Haager System“ des Internationalen Zivilprozessrechts handelt.
PERTUMBUHAN DAN HASIL PAKCOY (Brassica rapa L.) TERHADAP PEMBERIAN BIOCHAR TEMPURUNG KELAPA PADA TANAH GAMBUT PEDALAMAN
Authors: Abdul Hamid Syahrudin , Syahid Abdul , Dewi Sihite Irene , Adji Fengky F , Asie Kambang Vetranie
Published: October 2023

The purpose of this experiment was to study the growth and yield of pakcoy  (Brassica rapa L.) the giving of coconut shell  biochar on peat land. This research was conducted from June to August 2022. This research was conducted in a plastic house located on Jl. Haka, Panarung Village, Pahandut District, Central Kalimantan. This study used Randomized Compete Design (RCD) of single factor that was coconut shell  biochar consisting of 5 levels of treatment namely B0 (0 ton ha-1), B1 (4 ton ha-1),  B2 (6 ton ha-1), B3 (8 ton ha-1), and B4 (10 ton ha-1). The results showed that the application of coconut shell biochar had a significant effect on the growth and yield of pakcoy plants on peat land. Application coconut shell biochar dose of  B4 = 10 ton ha-1 (113.6 g. polybag-1) was the best treatment for the growth and yield of pakcoy plants on peat land with an average plant fresh weight of 91.92 g-1.
EFEKTIVITAS MACAM AMPAS KOPI TERHADAP STEK “BUNGA PLASTIK” DI DISTRIK KURULU KABUPATEN JAYAWIJAYA
Authors: Mahanani Anti Uni , Tulak Alber , Suryani S.D.A. , Amiruddin Natsir Akhmad , Nathan Kogoya Geztha , Bogum Itera
Published: October 2023

"Plastic Flower" (Xerochrysum bracteatum) belongs to the Chrysanthemum family. This flower is obtained from the wilderness so it takes effort to develop it. One way to develop it is to apply the provision of organic nutrients sourced from coffee grounds waste. Coffee grounds waste is beneficial for plants to increase their intake of nitrogen, phosphorus and potassium. The aims of the research: 1) to find out the effectiveness of coffee grounds on "Plastic Flower" cuttings; 2) the best type of coffee grounds for growth and cuttings "Plastic Flowers". The research design was a randomized block design consisting of K0 = without coffee grounds (control); K1 = Local coffee grounds, K2 = Kapal Api coffee grounds, K3 = Garuda coffee grounds, K4 = Uang Mas coffee grounds, K5 = Mocca ABC coffee grounds, repeated 5 times. Conclusion: 1) Coffee grounds have a significant effect on the number of shoots aged 4 MST and 6 MST; number of leaves aged 6 MST and 8 MST; live cuttings; rooted cuttings; root length; root fresh weight; The root dry weight of "Bunga Plastik" cuttings and the best type of coffee grounds for the growth and development of cuttings is local Wamena coffee grounds (K4).
Pengaruh Pemberian Ampas Kopi Terhadap Pertumbuhan dan Hasil tanaman Caisim (Brassica chinensis L.) Pada tanah Spodosol
Authors: Undut Saurdot Pakpahan , Sulistiyanto Yustinus , Sinaga Soaloon , Sirenden Ruben Tinting , Amelia Vera
Published: October 2023

The purpose of this study was to determine the real effect of coffee grounds on the growth and yield of caisim (Brassica chinensis L.) and to determine the appropriate dose of coffee grounds to increase the growth and maximum yield of caisim (Brassica chinensis L.). This research was conducted from April 2022 to May 2022 at the Peat Techno Park (PTP) University of Palangka Raya. This study used an environmental design, namely Completely Randomized Design (CRD) with 5 treatments and 4 replications. The treatments were Control (P0), 20 g (P1), 40 g (P2), 60 g (P3), 80 (P4). The parameters used in this study were plant height, number of leaves, year width, crown weight and root weight. From the observations obtained, it was analyzed to determine the real effect of the treatment using analysis of variance (F test) at the level of α = 5% and 1%. Data analysis will be continued with the Least Significant Difference Test (LSD) at α = 5% to determine the significant difference between treatment levels. The treatment of coffee grounds significantly affected the height, number of leaves, leaf area, top crown weight and root weight of caisim plants. Giving 20 g of coffee grounds gave optimum results on the growth and yield of caisim plants.