bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementación de energías renovables como garantía al derecho fundamental a un ambiente sano en Colombia
Authors: Guerra Sanchez Marcela , Montaño Assaf Julián Camilo , Ascanio Mantilla Nataly Juliana
Published: December 2021

El Derecho a un ambiente sano es un derecho en constante evolución, y ha sido objeto de debate en el desarrollo económico de los Estados, en razón a ello analizaremos como la implementación de energías renovables constituye una garantía al Derecho Fundamental al Ambiente Sano; En ese sentido, se realizó un estudio detallado de la normatividad colombiana y normas de Derecho Internacional aplicables al tema objeto de estudio, con el objetivo de analizar ¿Cómo la implementación de las energías renovables constituye una garantía al derecho fundamental a un ambiente sano en Colombia según los pronunciamientos de la Corte Constitucional y el Consejo de Estado? El tema fue abordado a través de un análisis teórico-documental, aplicando las reglas de la interpretación hermenéutica. Esta publicación, advierte sobre la carencia en regulación normativa que posee el Estado colombiano y con ello el incumplimiento a los Convenios y Tratados ratificados por Colombia.
An innovative subterranean spring capture method for improved water quality
Authors: Ten Pas Derek , Bogdajewicz Carly , Wildschut Julie , Tatko Chad , Hoeksema Robert
Published: December 2021

Many rural communities in Andean countries of South America rely on springs as their primary drinking water source. A variety of spring capture methods are employed resulting in varying water quality. Water from these spring-fed sources, delivered to the community via a distribution network, is often not chlorinated, increasing the risk of water-borne pathogens. A simple, improved technique has been developed in Ecuador's Chimborazo Province by a local Christian organization, Corporación de Desarrollo Integral Socio Económico (CODEINSE), to protect spring water sources for community water supply. This new technique, ‘the CODEINSE method’, builds on the strengths of traditional subterranean spring captures while employing several design improvements, like a concrete cap and sufficient gravel pack, to prevent surface water contamination. According to water quality data collected in Ecuador, the CODEINSE method consistently provides high-quality water with substantially reduced levels of water-borne pathogens compared to traditional spring capture methods. On average, the CODEINSE method yields water with less than 1.0 CFU/100 mL, water that is deemed no risk by the World Health Organization. The CODEINSE method has the potential to improve water quality not only in the rural Andean communities in Ecuador but also in developing countries across the world.
Exceso de peso en preescolares de Centroamérica y México en los últimos 30 años
Authors: Steinkoler-Sabah Eva , Segura-Buján Marco Vinicio , Restrepo-Betancur Luis Fernando
Published: December 2021

El exceso de peso en edades tempranas se ha incrementado en los últimos años a nivel mundial, lo que puede propiciar una mayor prevalencia de Enfermedades Crónicas no Transmisibles en etapas posteriores de la vida. El objetivo de este estudio fue comparar el porcentaje de sobrepeso en niños de dos a cuatro años en los diferentes países de Centroamérica y México, con base en la información reportada por Our World in Data y Cepal, en el periodo comprendido entre los años 1990 y 2020. Se empleó el modelo lineal general con transformación BOX-COX, a fin de validar los supuestos estadísticos del modelo, encontrando que Costa Rica se diferencia estadísticamente (p<0,05) de las demás naciones de Centroamérica respecto al porcentaje de exceso de peso. Dicha nación presenta los porcentajes más altos a lo largo del tiempo, mientras Honduras posee el menor valor. Es necesario establecer políticas públicas en las que se promueva una alimentación saludable y un estilo de vida adecuado, desde edades tempranas, para un correcto desarrollo, a fin de disminuir la aparición de enfermedades en el futuro, permitiendo mejor calidad de vida.
A PATRIMONIALIZAÇÃO COMO PROCESSO DE PRODUÇÃO SOCIAL DO ESPAÇO URBANO: ASPECTOS TEÓRICOS
Authors: CASTRO Cleber Augusto Trindade , TAVARES Maria Goretti da Costa
Published: December 2021

O termo “patrimonialização” tem sido utilizado em análises geográficas, referindo-se às relações espaciais dos processos de classificação de elementos culturais como patrimônio cultural. Diante disso, este artigo objetiva apresentar e analisar aspectos teóricos e conceituais da abordagem do processo de patrimonialização enquanto tendência atual de produção social do espaço urbano, como consequência de uma revisão da literatura que forneceram os subsídios teóricos e conceituais. A contribuição atual da patrimonialização para o processo de produção social do espaço urbano dá-se principalmente pela atuação do Estado, como legitimador desse processo, de agentes econômicos da oferta mercadológica, que usam os espaços patrimonializados para reprodução do capital ou para a sobrevivência humana através do trabalho e por movimentos sociais, sobretudo ligados às políticas culturais.
An overview of methods used for quantification of heavy metal contents in vegetal samples
Authors:   University of Agronomic Sciences and Veterinary Medicine, Faculty of Agriculture, Vasile Scaeteanu Gina , Majdar Rodica Maria , Mot Andrei ,   Research Center for Studies of Food and Agricultural Products Quality
Published: December 2021

Continuous monitoring of heavy metals content in vegetal products is a priority for food control and a risk assessment strategy for human health. Having in view the importance of heavy metals surveillance, the aim of this paper is to identify, on the basis of literature data, the most suitable procedures and techniques used for accurate determination of them in vegetal samples. In most cases, quantification of heavy metals in the vegetal matrix is preceded by digestion performed through different protocols chosen carefully because this is a critical step for obtaining accurate results. Among most used techniques for heavy metals’ assessment from vegetal products reported by literature it worth to be mentioned: atomic absorption spectrometry (AAS), inductively coupled plasma-mass spectrometry (ICP-MS), inductively coupled plasma - optical emission spectrometry (ICP-OES), X-ray fluorescence (XRF), neutron activation analysis (NAA), anodic stripping voltammetry (ASV).
Exposure assessment using biomonitoring
Authors:   National Research and Development Institute for Industrial Ecology, Cozea Andreea , Tanase Gheorghita , Neagu Mihaela ,   S.C. Hofigal S.A., Bucharest, Romania
Published: December 2021

Complex studies were performed combining macroscopic and biochemical analyzes of selected biomonitors, exposed in exposure systems outdoor with mixtures of pollutants as well as controlled exposure with certain concentrations of pollutants in fumigation chambers. In this study, the following plant species were used as bioindicators: Nicotiana tabacum, Petunia hybrida, Ricinus comunis, Trifolium pretense. The exposure plant samples were compared with control samples of biomonitors maintained under standardized conditions in the climate chamber. Classical methods of biochemistry combined with those of exposure biomonitoring have led to the completion of knowledge about the ways of action of plants to pollution. The analysis of some of the antioxidant compounds that are representing a structural class of chemicals (enzymes) with a wide range of biological functions, with the role of free radical inhibition, was performed. Many of the constituent compounds in certain cell types, also called active compounds, in this case, polyphenols are present in the body of some plant species. Polyphenol's presence in organisms, that are not usually present or are in normal quantities, is caused by stress, (pollution being a stress factor). Large amounts of polyphenols in plants are also given by the presence of pollutants in the environment. Through these extensive combined studies, it has been demonstrated that pollution can be a degenerative factor at the biochemical and physiological level, at the plant tissue level, with irreversible effects.
Short investigation on occurrence and removal of semivolatiles during wastewater treatment processes
Authors:   National Research and Development Institute for Industrial Ecology, Puiu Maria Diana
Published: December 2021

The food industry wastewater is known to present a high organic matter content, due to specific raw materials and processing activities. Even if these compounds are not directly toxic to the environment, high concentrations in effluents could represent a source of pollution as discharges of high biological oxygen demand may impact receiving river's ecosystems. Identifying the main organic contaminants in wastewater samples represents the first step in establishing the optimum treatment method. The sample analysis for the non-target compounds through the GC-MS technique highlights, along with other analytical parameters, the efficiency of the main physical and biological treatment steps of the middle-size Wastewater Treatment Plant (WWTP). Long-chain fatty acids and their esters were the main abundant classes of non-target identified compounds. The highest intensity detection signal was reached by n-hexadecanoic acid or palmitic acid, a component of palm oil, after the physical treatment processes with dissolved air flotation, and by 1-octadecanol after biological treatment.
The influence of toxic metals As, Cd, Ni and Pb on nutrients accumulation in Mentha piperita
Authors:   National Research and Development Institute for Industrial Ecology, Dinu Cristina , Vasile Gabriela Geanina , Tenea Anda Gabriela , Stoica Catalina , Gheorghe Stefania , Serban Ecaterina Anca
Published: December 2021

Medicinal plants are, for a considerable part of the population, an important source of treatment for certain diseases. They contain essential nutrients for the human body such as magnesium, iron , and zinc. The present study shows the influence of the addition of As, Cd, Ni, Pb on mineral nutrients in different organs of Mentha piperita. The experiments were carried out in the laboratory for a period of three months (May-July). Mentha piperita plants were AsCd and AsCdNiPb exposed up to final concentrations corresponding to the soil intervention threshold according to Romanian Order no.756/1997 (25 mg/kg As, 5 mg/kg Cd, 150 mg/kg Ni and 100 mg/ kg Pb). Simultaneously with these experiments, a control experiment (M) was performed. To evaluate the effect of the addition of AsCd and AsCdNiPb on the accumulation and transfer of Ca, Cr, Cu, Mn, Mo, Fe and Zn, the transfer coefficient (TC), the translocation factor (TF), and the enrichment factor (EF) were calculated. A higher concentration of Ca, Cr, Cu, Fe, Mn, Mo, and Zn was observed especially in the mint root in the experiments in which AsCdNiPb was added compared to those in which only AsCd was added. The AsCdNiPb addition did not influence the translocation of micro and macronutrients from the root to the aerial (edible) parts of the plant. In the case of the AsCd, addition, the translocation of zinc from the root to the aerial parts (leaves and stem) of the plant was increased.
Small Molecules Originated from Tryptophan and their Clinical Significance
as Potential Biomarkers
Authors: Miękus Natalia , Kowalik Katarzyna , Bączek Tomasz
Published: December 2021

Background:

L-tryptophan is an essential amino acid necessary for the human body to
function. Its degradation occurs through two metabolic pathways. Approximately 95 % of the Ltryptophan
available in the body is converted via the kynurenine pathway, while the remainder is
degraded via the serotonin pathway. Properly maintained balance between the concentrations of
individual small molecular metabolites is extremely important to maintain homeostasis in the human
body, and its disruption could lead to the development of numerous neurological, neurodegenerative,
neoplastic, as well as cardiovascular diseases. Recent reports have suggested that by
controlling the levels of selected L-tryptophan metabolites (potential biomarkers), it is possible to
diagnose numerous diseases, monitor their course, and assess patient prognosis.

Objective:

The aim of this paper is to review the currently important clinical applications of selected
biomarkers from the L-tryptophan metabolism pathways that would be helpful in early diagnosis,
monitoring the course and treatment of serious diseases of affluence, which ultimately could
improve the patients’ quality of life, as well as support targeted therapy of the aforementioned diseases.

Conclusion:

Since the biochemical biomarkers determination in body fluids presents the ideal minimally
invasive tool in the patents’ diagnosis and prognostication, this study emphasizes the current
trends and perspectives of application of analysis of selected L-tryptophan metabolites named
kynurenine and serotonin-derived small compounds in the routine medical procedures.
Identification of Conserved Epitopes in SARS-CoV-2 Spike and Nucleocapsid
Protein
Authors: Forcelloni Sergio , Benedetti Anna , Dilucca Maddalena , Giansanti Andrea
Published: December 2021

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel
virus that first occurred in Wuhan in December 2019. The spike glycoproteins and nucleocapsid
proteins are the most common targets for the development of vaccines and antiviral drugs.

Objective:

We herein analyze the rate of evolution along with the sequences of spike and nucleocapsid
proteins in relation to the spatial locations of their epitopes, previously suggested to contribute
to the immune response caused by SARS-CoV-2 infections.

Methods:

We compare homologous proteins of seven human coronaviruses: HCoV-229E, HCoV-
-OC43, SARS-CoV, HCoV-NL63, HCoV-HKU1, MERS-CoV, and SARS-CoV-2. We then focus
on the local, structural order-disorder propensity of the protein regions where the SARS-CoV-2 epitopes
are located.

Results:

We show that most of nucleocapsid protein epitopes overlap the RNA-binding and dimerization
domains, and some of them are characterized by a low rate of evolutions. Similarly, spike
protein epitopes are preferentially located in regions that are predicted to be ordered and wellconserved,
in correspondence of the heptad repeats 1 and 2. Interestingly, both the receptor-binding
motif to ACE2 and the fusion peptide of spike protein are characterized by a high rate of evolution.

Conclusion:

Our results provide evidence for conserved epitopes that might help develop broad-
-spectrum SARS-CoV-2 vaccines.
2 Receptor Specific Ligand Conjugated Nanocarriers: An Effective Strategy for Targeted Therapy of Tuberculosis
Authors: Sawarkar Sujata , Prabhu Pratiksha , Fernandes Trinette , Damani Mansi , Chaubey Pramila , Narayanan Shridhar
Published: December 2021

:

Tuberculosis (TB) is an ancient chronic disease caused by the bacillus Mycobacterium tuberculosis, which has affected mankind for more than 4,000 years. Compliance with the standard conventional treatment can assure recovery from tuberculosis, but the emergence of drug-resistant strains poses a great challenge for the effective management of tuberculosis. The process of discovery and development of new therapeutic entities with better specificity and efficacy is unpredictable and time-consuming. Hence, delivery of pre-existing drugs with improved targetability is the need of the hour. Enhanced delivery and targetability can ascertain improved bioavailability, reduced toxicity, decreased frequency of dosing and therefore better patient compliance. Nanoformulations are being explored for effective delivery of therapeutic agents, however, optimum specificity is not guaranteed. In order to achieve specificity, ligands specific to receptors or cellular components of macrophage and Mycobacteria can be conjugated to nanocarriers. This approach can improve localization of existing drug molecules at the intramacrophageal site where the parasites reside, improve targeting to the unique cell wall structure of Mycobacterium or improve adhesion to the epithelial surface of intestine or alveolar tissue (lectins). The present review focuses on the investigation of various ligands like Mannose, Mycolic acid, Lectin, Aptamers, etc., installed nanocarriers that are being envisaged for targeting antitubercular drugs.
Pharmacological Importance of Peach Gum Polysaccharide: A Review
Authors: Goh Ken Yang , Gew Lai Ti
Published: December 2021

Background:

Peach gum is a natural gum exudate secreted from a peach tree (Prunus
persica) by a process known as physiological gummosis. Peach gum is a natural biopolymer that is
composed of acidic polysaccharides with a high percentage of arabinose and galactose subunit,
which classifies it as an arabinogalactan.

Objectives:

This review summarizes the composition, chemical structures, physical properties and
biological properties of peach gum, and its potential biotechnological applications.

Method:

A literature search was performed using Google Scholar with keywords as Peach Gum
and Prunus persica. Only articles written in English and articles with downloadable full-texts were
included in this review.

Results:

Peach gum polysaccharides possess antibacterial, antioxidant and anti-diabetic, and hypolipidemic
properties. Excellent emulsification properties of PGP show that it has the potential to
be employed as a food-grade emulsifier.

Conclusion:

PGP exhibits excellent emulsification, antioxidant, antibacterial, anti-diabetic and hypolipidemic
properties. As plastic pollution has become an alarming global issue, PGP could be a
promising edible raw material in the field of bioplastic research and development.
Locus of Control and Dizziness: Mediation Effect of Self-Efficacy
Authors: Jeong Yemo , Jin Won Hwa , Kwon Eun-Jin , Kwon In-Sun , Yu Han Young , Jeong Seong-Hae
Published: December 2021

Objectives: An attention to psychological aspects can clarify the understanding and management of patients with unresolved dizziness/vertigo. Thus, we study the locus of control and the mediation effect of self-efficacy for assessing the relationship between locus of control and dizziness/vertigo in a referral-based dizziness clinic.Methods: We analyzed the dizziness-specific locus of control and self-efficacy using the modified questionnaire in 117 consecutive dizzy patients (34 males; age range, 20–74 years). In addition to the visual analogue scale-dizziness for evaluation of subjective dizziness, the following items were further evaluated; Korean Dizziness Handicap Inventory, Korean Beck Depression Inventory II, and Korean Beck Anxiety Inventory. According to the verification procedure proposed by Hayes, the mediation effect of self-efficacy verifies the relationship between the locus of control and dizziness through analysis.Results: Except the scale of emotion such as anxiety and depression, sex, age, duration of illness, and diagnosis all did not significantly affect the dependent variables. Vestibular migraine (39.3%), vestibulopathy (15.4%), and dizziness associated with anxiety and depression (14.5%) were the most common diagnoses. On all scales, Cronbach’s α ranged from 0.72 to 0.94. In the direct effect, the internal locus of control had a tendency of aggravation of dizziness/vertigo, but in the indirect effect, the higher the internal locus of control, the higher the self-efficacy, and the higher the self-efficacy, the lower the dizziness.Conclusions: In our study, we can assume that the locus of control can impart ambivalent effects on dizziness/vertigo. And the modulation of self-efficacy could be another treatment for patients with unresolved dizziness.
Isolated Floccular Infarction with Impairment of High-Frequency Vestibulo-Ocular Reflex: A Case Report
Authors: Oh Eun Hye , Kim Hyun-Sung , Choi Jae-Hwan
Published: December 2021

The flocculus plays a crucial role in control of eye movements. Based on animal experiment, it is suggested that the flocculus is important for governing vestibuleocular reflexes. In humans, an isolated floccular lesion is extremely rare. We report oculomotor abnormalities in a patient with unilateral infarction of the flocculus, and compare our results with those of previously reported patients with floccular lesion.
Un nuevo registro de Podagrostis (Poaceae, Pooideae, Poeae) para México
Authors: Vigosa-Mercado José Luis
Published: December 2021

Antecedentes y Objetivos: El género Podagrostis incluye 12 especies, incluidas anteriormente en Agrostis y hasta hace poco se tenía conocimiento de la existencia de tres especies en México. La revisión de ejemplares de herbario reveló la presencia de una cuarta especie, conocida previamente solo de Guatemala. El objetivo de este trabajo es describir e ilustrar el nuevo registro, y discutir la identidad del ejemplar examinado y las diferencias morfológicas de esta especie con las otras mexicanas.Métodos: Se revisaron ejemplares de herbario de Agrostis y Podagrostis de México y Centroamérica, en colecciones físicas y digitales. Se tomaron fotografías de las estructuras reproductivas importantes para la identificación.Resultados clave: Se registra aquí por primera vez a Podagrostis exserta para México, en el estado de Oaxaca. Se discuten la identidad del ejemplar examinado y las diferencias de esta especie con las otras especies mexicanas de Podagrostis. Se presenta una clave dicotómica para diferenciarlas.Conclusiones: El género Podagrostis está representado en México por cuatro especies: P. exserta, P. liebmannii, P. novogaliciana y P. rosei, que se distinguen de Agrostis por las espiguillas con la raquilla prolongada. Se destaca la importancia de la labor curatorial en las colecciones de los herbarios mexicanos.
Photobiomodulation for Complex Regional Pain Syndrome: A Case Report and Literature Summary
Authors:   LaserMD Pain Relief, 2809 N. Sepulveda Blvd, Manhattan Beach, CA 90266, USA, Sweeney Megan , Kraft Harold ,   LaserMD Pain Relief, 2809 N. Sepulveda Blvd, Manhattan Beach, CA 90266, USA
Published: December 2021

Complex Regional Pain Syndrome (CRPS) is a highly debilitating chronic pain condition characterized by continuous regional pain disproportionate to duration and intensity of the initial damaging stimulus. In CRPS, abnormal perception, transmission, and modulation of pain by nerve cells and the autonomic nervous system induces extreme increases in perceived pain that may be accompanied by swelling, temperature sensitivity, color fluctuations, and/or skin changes. CRPS most commonly affects the extremities but may spread to other limbs or bodily locations. Since there is currently no cure for the underlying processes that play a role in causing this debilitating condition, therapeutic options seek to mitigate some of the symptoms of CRPS to improve quality of life. A recent systematic review found low-quality evidence of efficacy for all currently available CRPS treatments as well as a lack of consensus about first-line treatments. The pathophysiological complexity of CRPS, in addition to the lack of non-invasive, efficacious therapies for this extremely burdensome pain condition, highlights the vital need to explore novel therapeutic options in both research and clinical practice. Photobiomodulation through the repeated application of high-intensity laser therapy in a clinical setting has been shown to modulate nociception, minimize inflammation, and reduce different types of chronic and acute pain. The present case report describes a clinical protocol using laser therapy for CRPS, presents longitudinal pain scores, and summarizes mechanisms of action supporting the subsequent reduction of CRPS symptoms. After a series of laser treatments, the patient showed marked improvement in range of movement, hypersensitivity, pain, and function. Photobiomodulation through high-intensity laser therapy may represent a promising therapy for individuals affected by CRPS, although further randomized, controlled trials are recommended to evaluate efficacy on different disease-affected areas, assess dose-response relationships, and refine optimal treatment frequency.
Health Care Students’ Perspectives on Artificial Intelligence: Countrywide Survey in Canada
Authors: Teng Minnie , Singla Rohit , Yau Olivia , Lamoureux Daniel , Gupta Aurinjoy , Hu Zoe , Hu Ricky , Aissiou Amira , Eaton Shane , Hamm Camille , Hu Sophie , Kelly Dayton , MacMillan Kathleen M , Malik Shamir , Mazzoli Vienna , Teng Yu-Wen , Laricheva Maria , Jarus Tal , Field Thalia S
Published: December 2021

Background

Artificial intelligence (AI) is no longer a futuristic concept; it is increasingly being integrated into health care. As studies on attitudes toward AI have primarily focused on physicians, there is a need to assess the perspectives of students across health care disciplines to inform future curriculum development.

Objective

This study aims to explore and identify gaps in the knowledge that Canadian health care students have regarding AI, capture how health care students in different fields differ in their knowledge and perspectives on AI, and present student-identified ways that AI literacy may be incorporated into the health care curriculum.

Methods

The survey was developed from a narrative literature review of topics in attitudinal surveys on AI. The final survey comprised 15 items, including multiple-choice questions, pick-group-rank questions, 11-point Likert scale items, slider scale questions, and narrative questions. We used snowball and convenience sampling methods by distributing an email with a description and a link to the web-based survey to representatives from 18 Canadian schools.

Results

A total of 2167 students across 10 different health professions from 18 universities across Canada responded to the survey. Overall, 78.77% (1707/2167) predicted that AI technology would affect their careers within the coming decade and 74.5% (1595/2167) reported a positive outlook toward the emerging role of AI in their respective fields. Attitudes toward AI varied by discipline. Students, even those opposed to AI, identified the need to incorporate a basic understanding of AI into their curricula.

Conclusions

We performed a nationwide survey of health care students across 10 different health professions in Canada. The findings would inform student-identified topics within AI and their preferred delivery formats, which would advance education across different health care professions.
Examining the Impact of Digital Components Across Different Phases of Treatment in a Blended Care Cognitive Behavioral Therapy Intervention for Depression and Anxiety: Pragmatic Retrospective Study
Authors: Wu Monica S , Wickham Robert E , Chen Shih-Yin , Chen Connie , Lungu Anita
Published: December 2021

Background

Depression and anxiety incur significant personal and societal costs. Effective psychotherapies exist, such as cognitive behavioral therapy (CBT); however, timely access to quality care is limited by myriad barriers. Blended care therapy models incorporate traditional face-to-face therapy with scalable, digital components of care, expanding the reach of evidence-based care.

Objective

The aim of this study is to determine the effectiveness of a blended care CBT program (BC-CBT) in real-world settings and examine the unique impacts of the (1) digital components of care (video lessons and digital exercises) and (2) phase of treatment (early versus late) in decreasing symptoms of anxiety and depression.

Methods

This retrospective cohort analysis included 3401 US-based individuals enrolled in a BC-CBT program, who presented with clinical levels of depression and/or anxiety. The treatment program consisted of regular therapy sessions augmented by clinician-assigned digital video lessons and exercises. A growth curve model incorporating time-varying covariates examined the relationship between engagement with BCT components (ie, therapy sessions, digital video lessons, and digital exercises) during the early (weeks 0-7) and late (weeks 8-15) phases of treatment, and weekly symptom reports on depression and anxiety measures.

Results

On average, a significant decline in depression and anxiety symptoms was observed during the initial weeks of treatment (P<.001), with a continued, though slower, decline over subsequent weeks (P<.001). Each session completed was associated with significant decreases in anxiety (b=–0.72) and depression (b=–0.83) in the early phase, as well as in the late phase (anxiety, b=–0.47; depression, b=–0.27). Significant decreases in anxiety (b=–0.15) and depression (b=–0.12) were observed for time spent on video lessons (measured in 10-minute intervals) in the early phase of treatment. Engaging with exercises was associated with statistically significant increases in anxiety symptoms (b=0.03) during the early phase of treatment. However, sensitivity analyses examining the effects of exercises in isolation revealed significant decreases in anxiety (b=–0.05) in the early phase, suggesting a potential suppression effect in the larger model.

Conclusions

Using a retrospective cohort design, therapy sessions and digital video lessons were uniquely predictive of improvements in depression and anxiety symptoms, and their effects were modulated based on the phase of treatment (early vs late). Future research should investigate whether other treatment variables, such as therapeutic alliance or familiarity with technology, are related to differential effects on various components of care.
Preferences for Mobile-Supported e-Cigarette Cessation Interventions Among Young Adults: Qualitative Descriptive Study
Authors: Huma Zil E , Struik Laura , Bottorff Joan L , Hasan Mohammad Khalad
Published: December 2021

Background

Despite the steady rise in electronic cigarette (e-cigarette) uptake among young adults, increasingly more young people want to quit. Given the popularity of smartphones among young adults, mobile-based e-cigarette cessation interventions hold significant promise. Smartphone apps are particularly promising due to their varied and complex capabilities to engage end users. However, evidence around young adults’ preferences and expectations from an e-cigarette cessation smartphone app remains unexplored.

Objective

The purpose of this study was to take an initial step toward understanding young adults’ preferences and perceptions on app-based e-cigarette cessation interventions.

Methods

Using a qualitative descriptive approach, we interviewed 12 young adults who used e-cigarettes and wanted to quit. We inductively derived themes using the framework analysis approach and NVivo 12 qualitative data analysis software.

Results

All participants agreed that a smartphone app for supporting cessation was desirable. In addition, we found 4 key themes related to their preferences for app components: (1) flexible personalization (being able to enter and modify goals); (2) e-cigarette behavior tracking (progress and benefits of quitting); (3) safely managed social support (moderated and anonymous); and (4) positively framed notifications (encouraging and motivational messages). Some gender-based differences indicate that women were more likely to use e-cigarettes to cope with stress, preferred more aesthetic tailoring in the app, and were less likely to quit cold turkey compared with men.

Conclusions

The findings provide direction for the development and testing of app-based e-cigarette cessation interventions for young adults.
A Validated Questionnaire to Evaluate Primary Care Pediatrician Satisfaction With the Use of Teledermatology (Preprint)
Authors: Palazón Cabanes Juan Carlos , Juan Carpena G , Berbegal García L , Martínez Miravete T , Palazón Cabanes B , Betlloch Mas I
Published: December 2021

BACKGROUND

Teledermatology (TD) is a branch of telemedicine focused on the evaluation of cutaneous lesions by dermatologists remotely, in order to avoid unnecessary in-person consults that could be otherwise resolved by this method, and to shorten the time required for prompt evaluation of cutaneous diseases.

OBJECTIVE

This study aimed to create and validate a questionnaire to evaluate satisfaction with the use of TD among primary care pediatricians (PCPs) and to test the questionnaire in our health area before performing an intervention for the optimization of TD.

METHODS

We first created a questionnaire based on previous publications. Then, an expert consultation was made before drafting the final version of the questionnaire. We tested it twice among pediatricians of different health areas, with a 1-month gap between both evaluations. Internal consistency, reproducibility, and validity of the questionnaire were evaluated. Finally, the validated questionnaire was tested among the PCPs of our health area, to analyze their responses.

RESULTS

We registered 38 questionnaire responses. In all, 30 (78.9%) PCPs actively used TD several times within a month or a year; none of them used TD daily. Technical and health care quality of TD was mostly considered as good or very good. TD was regarded as similar or even better than face-to-face evaluation for most PCPs, whereas 7.9% (3/38) of PCPs thought TD was worse than conventional consults. Most PCPs considered TD as an effective, self-learning, and trustable tool, and 10.5% (4/38) of them identified that pictures captured by mobile phones were a barrier for its use, as it affects patient privacy. Technical problems, absence of exclusive devices for image taking, and delayed answers are some other barriers for TD that need to be overcome. Nonetheless, all PCPs were satisfied with TD, and all of them reported they would continue or start to use this tool.

CONCLUSIONS

TD has demonstrated to be an efficient tool, as it reduces waiting time and costs for dermatology evaluation, and it increases satisfaction among professionals. With our proposed questionnaire, we validated that quality, usability, efficacy, and satisfaction related to TD in our health area had a positive consideration among PCPs in general, but there still are barriers to overcome.
The Dynamic Digital Twin: diagnosis, treatment, prediction and prevention of disease during the life course (Preprint)
Authors: Mulder Skander Tahar , Omidvari Amir-Houshang , Rueten-Budde Anja,J. , Huang Pei-Hua , Kim Ki-Hun , Bais Babette , Rousian Melek , Hai Rihan , Akgun Can , van Lennep Jeanine Roeters , Willemsen Sten , Rijnbeek Peter R , Tax David M.J. , Reinders Marcel , Boersma Erik , Rizopoulos Dimitris , Visch Valentijn , Steegers-Theunissen Régine
Published: December 2021

UNSTRUCTURED

A Digital Twin (DT), which is defined originally as a virtual representation of a physical asset,
system or process, is a new concept in healthcare. DT in healthcare cannot be a single technology,
but a domain adapted multi-modal modelling approach, which incorporates the acquisition,
management, analysis, prediction, and interpretation of the data, aiming to improve medical decision
making. However, there are many challenges and barriers that has to be overcome before a DT can
be used in healthcare. In this viewpoint paper, we address these challenges, and envision a dynamic
DT in healthcare for optimizing individual patient health care journeys. We describe how we can
commit multiple domains to developing this DT. With our cross-domain definition of the DT, we aim
to define future goals, trade-offs, and methods, which guide the development of the dynamic DT and
the implementation strategies in healthcare.
Вплив ендотоксикозу на вегетативний статус пацієнтів з хронічним панкреатитом
Authors: Babinets L.S. , Sabat Z.I.
Published: December 2021

Актуальність. Одними з визначальних типових клініко-патогенетичних синдромів формування і тяжкості перебігу хронічного панкреатиту (ХП) є синдроми ендогенної інтоксикації (СЕІ) та вегетативної дисфункції (ВД). Досліджень гематологічних індексів запалення та інтоксикації, а особливо у співставленні із параметрами вегетативного статусу при ХП нами знайдено не було, що й мотивувало до проведення даної науково-дослідної роботи. Мета дослідження: встановити взаємозв’язки гематологічних індексів запалення та інтоксикації і параметрів вегетативного статусу пацієнтів із хронічним панкреатитом. Матеріали та методи. Було обстежено 69 пацієнтів з діагнозом ХП, які лікувалися амбулаторно. Визначали наступні гематологічні індекси: лейкоцитарний індекс інтоксикації (ЛІІ), індекс адаптації (ІА) з подальшим визначенням типу неспецифічної адаптаційної реакції, лімфоцитарно-гранулоцитарний індекс (ІЛГ). Вивчались кореляційні зв’язки ЛІІ з параметрами психо-емоційного стану (нейротизмом, реактивною (РТ) та особистісною (ОТ) тривожністю згідно з опитувальниками Айзенка, Спілбергера-Ханіна), ВД за даними опитувальника Вейна, тривалістю захворювання. Результати. У 63% пацієнтів з хронічним панкреатитом встановлено наявність ендогенної інтоксикації легкого та середнього ступеня тяжкості за індексом Кальфа-Каліфа, що робить необхідним застосування препаратів, спрямованих на її корекцію. Встановлено достовірні кореляційні зв’язки між ЛІІ та особистісною тривожністю (прямий слабкий r=0,23, p<0,05), нейротизмом (прямий середньої сили r=0,41, p<0,05), вегетативною дисфункцією (прямий слабкий r=0,1, p<0,05), тривалістю захворювання (прямий слабкий r=0,15, p<0,05), структурним станом підшлункової залози за УЗД-проявами у балах (прямий слабкий r=0,29, p<0,05), рівнем α-амілази панкреатичної (прямий середньої сили r=0,30, p<0,05). Отримані результати довели наявність достовірних взаємовпливів параметрів запалення та ендотоксикозу з показниками вегетативного статусу і стану підшлункової залози. Це робить необхідним призначення хворим з ХП протизапальних і вегетотропних засобів для посилення протокольного лікування. Висновки. Серед пацієнтів з ХП сприятливі адаптаційні реакції спостерігались лише у 36% обстежених, несприятливі – у 25%, проміжні – у 39%, а середнє значення індекса адаптації становило – 0,48±0,18, що відповідає верхній межі реакції орієнтування. Це мотивує до додаткового призначення таким пацієнтам з ХП вегетотропних і адаптогенних препаратів. Лише у 10% пацієнтів з хронічним панкреатитом загальна імунна відповідь не має відхилень від адекватної імунної реакції, у 48% обстежених спостерігається нездатність імунної системи завершити запалення, у 42% – переважання аутоімунного компоненту інтоксикації, що потребує посилити протизапальну терапію біорегуляційними препаратами з метою гармонійного завершення запалення.
Хронічний ендометрит та ендометріоз: чи є взаємозв’язок?
Authors: Pedachenko N.Y. , Tukhtarian R.A. , Avetis'yan I.L. , Shemelko T.L.
Published: December 2021

Актуальність. Хронічний ендометрит та ендометріоз мають багато спільних рис. Обидва захворювання є тривалими запальними процесами, з неуточненими до кінця етіологічними чинниками та патогенетичними механізмами, які негативно впливають на фертильність та можуть викликати тазовий біль або аномальну маткову кровотечу. Питання ефективної та своєчасної діагностики хронічного ендометриту залишається відкритим через відсутність специфічних клінічних симптомів та даних клінічного огляду. Мета: оцінка сучасних наукових доказів зв'язку між ендометріозом та хронічним ендометритом. Матеріали та методи. Проведено системний пошук наукової медичної інформації в англомовних базах даних: MEDLINE, Scopus, Web of Science, Medline, The Cochrane Library, PubMed. Результати. За даними огляду різних наукових досліджень, що проводились останнім часом, виявлено, що у пацієнток з ендометріозом ризик розвитку хронічного ендометриту статистично значимо вищий у 1,3-2,5 разів, ніж у жінок без ендометріозу. Із застосуванням гістологічного дослідження ендометрію та визначення CD138 хронічний ендометрит було виявлено у 52,94% жінок групи ендометріозу та у 27,02% пацієнток групи без ендометріозу; показник був значно вищим у групі ендометріозу, ніж у контрольній групі (р=0,0311). Більше того, у 76% жінок з ендометріозом виявлені запальні процеси тазових органів (у порівнянні з групою контролю, де запалення виявилось у 38,4% жінок, p<0.0001). Висновки. Пацієнтки з ендометритом демонструють позитивну кореляцію з розвитком ендометріозу. Враховуючи неможливість встановити причинно-наслідковий зв’язок ендометріозу та хронічного ендометриту необхідна розширена діагностика з метою виключення хронічного ендометриту, особливо, якщо жінки мають аномальну маткову кровотечу або хронічні тазові болі. Поєднання гістологічного та імуногістохімічного методів дослідження ендометрію показало свою ефективність у своєчасній діагностиці хронічного ендометриту. Виявлення та адекватне лікування даного стану допоможе уникнути непотрібного оперативного втручання.
Kondisi stres pada karyawan mempengaruhi tingkat konsumsi gula sederhana dan natrium
Authors: Ayuningtyas Cita Eri , Utami Nurul Putrie , Hariyono Widodo , Natalina Retno
Published: December 2021

Stress in work staff influenced simple sugar and sodium intakeBackground: Stress is a condition that occurs to individual experiences a burden of a problem that can not solve there for lead to an unspecific response from the body. One of the causes of stress is the load of work. Stress caused by work could lead to obesity, cardiovascular disease, and diabetes. Change of behavior during stress like eating behavior cause of changing appetite on the individual.Objective: This research was aimed to analyze simple glucose and sodium intake during stress in staff.Method: This was a cross-sectional research design. A total of 125 subjects were chosen by purposive random sampling. The subject was the educational staff of Universitas Ahmad Dahlan. Data was collected as identity, nutrition intake used the Semi-Quantitative Food Frequency Questionnaire (SQFFQ), and stress level used Depression Anxiety Stress Scales (DASS) questionnaire. The statistical test used the Chi-Square test.Results: There is no significant difference between a simple sugar and sodium intake to stress level (p>0.05). The average of simple sugar and sodium intake classified as normal as much as 56.49±77.20 g for simple sugar intake and as much as 653.30±464.55 mg for sodium derived from food ingredients added salt and preservative foods. Data characteristic showed that the nutritional status of 40,8% of the staff was overweight and obese. Conclusions: There is no significant difference between stress level and simple sugar and sodium intake.
Capital and ressentiment: The totalizing power of social fragmentation
Authors: Vogl Joseph
Published: December 2021

Joseph Vogl's new book, Capital and Ressentiment
(2021/2022), traces an epistemic shift from knowledge to information driven by
the convergence of financialization and the platform economy. As a variable that
is determined less by semantic content than by difference to existing
expectations, information invites indifference to other distinctions, such as
those between fact and fiction, claim and proof. The circulation of information
takes the form of opinion markets wherein the production of reality itself is at
stake. In this extract, taken from the book's final chapter, “The
cunning of ressentiment-driven reason”, Vogl analyses populist
ressentiment as both structural affect of and vital resource for information
capitalism, laying out the resulting reconfiguration of the social.
Colonialism, capital, and ressentiment
Authors: Cooiman Franziska
Published: December 2021

Vogl's new book relates finance to the internet industry and
economics to politics. Introducing questions of colonial history and racism
would further sharpen his view of the drivers and dynamics of contemporary
capitalism.
Hunter-gatherer mobility and territories in the dunefields of center Argentina
Authors: Messineo Pablo G. , Barros María P.
Published: December 2021

The distribution of certain rocks in the landscape allows us to reconstruct diverse aspects of past hunter-gatherer behavior. In this work, we evaluate the mobility patterns employed by these groups and the presence or absence of boundaries in the Aeolian system of the center of Argentina. To accomplish this objective, we consider two types of evidence: 1) raw material frequencies and distributions in three areas of this Aeolian System and 2) presence and frequency of knapping stones from Tandilia sources. We construct a fall-off curve that is based on the relationship between the frequency of an item and the distance to the source of supply. The characteristics of each area yielded the human groups that inhabited delineate different modes of exploitation of the rocks. The fall-off curve documents a steep drop-off between 300 and 350 km from the Tandilia source and the spatial analysis indicates that within this distance the source probably represents the threshold of direct access to the quarries. Tandilia stone-tools seem to systematically supply a relatively wide area of the Central Pampean Dunefields of the Pampa grasslands, through varied processes, but they arrive at very low frequencies over great distances. The presence of Tandilia rocks in the Western Pampean Dunefields and Western Pampas Sand Mantles and Dunefields indicates social interaction between human groups that shared some common technological knowledge. The presence of stones in the Central Pampean Dunefields coming from the xerophytic woodland of the Dry Pampas can be related with contacts and exchanges among the hunter-gatherer group that occupied different territories.
El límite material de la sustancia química
Authors: Chamizo José Antonio
Published: December 2021

La química tal y como la conocemos hoy es un sistema de prácticas científicas, experimentales, estabilizadas y enseñadas de la misma manera en la mayoría de los países. La química es heredera de una multitud de oficios que coinciden en transformar y crear nuevas sustancias. Aquí se discute el límite material de la sustancia química, ejemplificado a través del carbono, particularmente del experimento de difracción del C60.  Con ello se intentará precisar el concepto de sustancia química y su relevancia en la discusión filosófica actual.
Fanny Del Río, Las filósofas tienen la palabra
Authors: Mayans Hermida Itzel
Published: December 2021

Las reseñas bibliográficas no cuentan con resumen.
Advanced Footstep Power Generation using RFID for Charging
Authors: Dayal Priyanka Naresh Chandra
Published: December 2021

Abstract: Day by day, the population of the country is increasing and the requirement of the power is also increasing in many ways. So, reforming this energy back to usable form is the major solution for future needs. In this Footstep power generation project, power is generated by human’s footsteps, so as to charge the battery by storing the power generated with the help of piezo sensors. The power stored in the battery, used to charge the mobile phones using RFID card. This system is powered by Atmega 328 microcontroller, it consists of Arduino IDE, RFID Sensor, USB Cable and LCD. When power is on in the system, the system enters into the registration mode. Three users can registered. Once all the users entered in the system, then the system asks to swipe the card and connect the charger. Initially all the user is given 5 minutes of charging time as default. When card is swiped and the user is authorized, the system turns on for charging the Mobile phone within a given time period. Keywords: Arduino Uno, Arduino IDE, Piezoelectric Sensors, RFID (Radio Frequency Identification ), LCD
A Review Paper on Emotion Recognition Analysis on Real Time Video by Using the Concept of Computer Vision
Authors: Saha Rewati
Published: December 2021

Abstract: As we know we are living in the era of digital world where everything is based on data analysis, now a days after covid it’s really difficult to do the analysis on real world, so there is need of an algorithm which is able to do the analysis on virtual world, suppose there is any application which is able to identify the user feedback based on there emotion, so there is need of a novel algorithm which is work on the concept of the emotion analysis, in this paper basically we did the study about the previous existing work on emotion analysis and try to find out the research gaps and there future scope. Keywords: Computer Vision, Machine Learning, Emotion Analysis, Deep Learning