bluuebunny/crossref_metadata_2025 huggingface dataset:
GAMBARAN KEBIMBANGAN KARIER PADA MAHASISWA TINGKAT AKHIR DI UNIVERSITAS NEGERI PADANG BERDASARKAN PROGRAM STUDI DAN JENIS KELAMIN
Authors: Priyangga Yogi
Published: February 2024

Higher education is a formal educational institution that provides formal education with the aim of producing students with graduates who have skills, commendable character, quality and are ready to enter the world of work. However, in this process final year students are often faced with various challenges. One of these challenges is career indecision. This research was conducted with the aim of finding out the description of career indecision among final year students at Padang State University based on study program and gender. This research was studied using quantitative research with a comparative approach. Data collection was carried out using a questionnaire technique distributed via Whatsapp and Instagram to 277 respondents from 9 study programs at Padang State University. The data analysis technique in this research was carried out using the t-test, one way anova and two way anova. The results obtained in this research indicate that career indecision among final year students at Padang State University is in the low category. This research illustrates that final year students at Padang State University have sufficient motivation regarding career-related decision making. Apart from that, final year students also have sufficient information about matters relating to themselves or the world of work they will be involved in, and there are also no internal or external conflicts within the subject in determining his career choice.
Movilidad humana en México
Authors: Naranjo Sabina Yanet , González Valles María Nieves , Castro Valles Alberto
Published: February 2024

The objective was to describe the state of the art of three relevant categories regarding human mobility of adults who move to the United States mainly from Honduras, Guatemala, El Salvador, Venezuela and Mexico: a) driving factors, b) risks they face during the journey and c) consequences that the experience as a whole generates in the psychosocial, family, physical and mental health dimensions. Based on the review of various studies, the knowledge generated in the first decades of the 21st century on the continent is described. The findings indicated that the driving factors are mainly socioeconomic, political, environmental, the search for educational opportunities and family reunification. During the journey there is vulnerability and risks with multiple experiences of victimization, social and contextual violence. It is concluded that human mobility brings with it psychosocial consequences such as mental health problems, grief, family rearrangements, stigmatization, social and labor exclusion.
PEMIKIRAN DAN TEORI POLITIK ISLAM MUSTAFA KEMAL ATATURK
Authors: Islam Saehul , Wardana Dava
Published: February 2024

Tulisan ini membahas pemikiran Islam modern dari perspektif Mustafa Kemal khususnya reformasi Islam di Turki. Metode yang digunakan dalam penelitian ini yaitu penelusuran kepustakaan dengan pendekatan kualitatif. Analisis yang digunakan untuk menganalisis data adalah analisis konten. Hasil Penelitian menunjukkan bahwa Mustafa Kemal adalah salah satu pemimpin reformasi Islam yang berkualitas abad ke-19. Dia telah memberikan kontribusi besar untuk ini Perubahan cara berpikir orang Turki. Dengan mengubah tatanan lama yang telah tradisi di Kekaisaran Ottoman dan memberikannya wajah baru dengan cara berpikir yang sebenarnya tidak mengubah "Islam", tetapi hanya perubahan cara berpikir dan cara hidup umat Islam persyaratan waktu. Karena nilai-nilai Islam sebenarnya bisa melakukan itu didirikan di negara yang berbentuk khilafah, republik bahkan sekuler. Meskipun Sebenarnya simbol juga penting, tapi yang lebih penting, orang bisa melakukannya Membawa substansi Islam ke dalam setiap gerak kehidupan masyarakat. Ide-idenya telah mengubah Turki menjadi negara maju yang setara dengan dunia Sekaligus membuktikan bahwa pemerintahan Islam adalah satu Pemerintah sesuai dengan tuntutan zaman.
Back-Reef Depositional Environments in a Lower Cretaceous (Sligo) Shelf-Margin Complex: Insights into Ultradeep Reservoir Preservation and Controls on Stacking Patterns in an Outer Platform Setting
Authors: Hattori Kelly E. , Loucks Robert G. , Zeng Hongliu
Published: February 2024

The Early Cretaceous Sligo and Stuart City shelf-margin trends in Texas have been a subject of interest for over 60 years, attracting attention both because of their striking complex reef lithologies and their continued potential for oil and gas exploration. Numerous gas reservoirs have been discovered since the late 1950s, with a major push for revitalization and expansion occurring in the 2000s. The shelf-margin complexes originated as steep-walled reefs rimming the Comanche Platform. They evolved into a narrow (<6 mi) highly heterogeneous belt of banks, islands, shoals, and tidal flats with an associated highly productive shallow-water carbonate factory. Most characterization efforts for these systems have focused on known reservoirs in South Texas; very little work has investigated the margins outside of this region, particularly with respect to the Sligo shelf margin. This investigation presents the first well-documented long stratigraphic section for the Sligo margin in East Texas, which serves as an initial step in understanding this major shelf-margin complex. Facies are mainly associated with back-reef to back-reef lagoon environments and exhibit significant heterogeneity on the basis of variations in water depth and wave energy, with facies including argillaceous carbonate mudstones, oncolitic packstones, rudist biostromes, reef-derived grainstones, ooid grainstones, and algal laminate bindstones. Four depositional sequences are delineated based on broad changes in facies and stacking patterns related to water depth and energy regime, yielding new insight into controls on facies partitioning in a stable long-term shelf-margin complex. The pore network, which is limited to micropores, is largely facies-controlled and is related to the presence of originally Mg–calcite allochems such as miliolids and Lithocodium/Bacinella. As East Texas has significant structural complexity, the ultradeep buried Sligo Formation is an underexplored area with the potential for undiscovered reservoirs related to structural features. Geologic characterization of this core is an important step in understanding some of the porous lithofacies present within the Sligo shelf margin in East Texas.
Front Matter
Authors: Merrill Robert K. , Willis James J. , Mathews Jessica
Published: February 2024

n/a
Analisis Strategi Hotel X Dalam Menangani Keluhan Tamu Terhadap Fasilitas Dan Pelayanan
Authors: Elva Olivia  , Retnaningtyas Susanti  , Dwi Pratiwi Wulandari  , Arif Adrian
Published: February 2024

Penelitian ini dilatar belakangi oleh keluhan tamu terhadap fasilitas dan pelayanan di Hotel X yang ada pada media pemesanan online seperti traveloka, ticket.com, agoda dan trip. com. Ulasan tamu berisi keluhan diuraikan menjadi beberapa masalah yaitu masih banyak keluhan tamu tentang fasilitas hotel, masih banyak keluhan tamu tentang pelayanan hotel, belum ada tindakan yang dilakukan langsung oleh staf untuk mengatasi masukan dari keluhan tamu dan hotel memerlukan SDM yang memiliki kemampuan HEAT. Tujuan khusus dari penelitian ini adalah untuk menganalisis strategi Hotel X dalam menangani keluhan tamu terhadap fasilitas dan pelayanan menggunakan metode HEAT (hear them out, emphatize, apologize, taking action and follow up). Penelitian ini menerapkan metode penelitian studi kasus dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan melalui wawancara, observasi dan dokumentasi. Informan kunci dalam penelitian yaitu informan dari staf Hotel X dan Informan dari tamu Hotel X. Informan ditentukan secara purposive sampling untuk informan hotel melibatkan perwakilan 1 orang dari 3 departemen hotel yaitu departemen Front Office, departemen Housekeeping dan departemen Engineering. Informan tamu hotel yaitu melibatkan 2 orang tamu yang pernah menginap di Hotel X. Teknik analisis data dengan reduksi data, penyajian data dan pengambilan kesimpulan. Hasil penelitian menunjukkan analisis strategi Hotel X dalam menangani keluhan fasilitas dan keluhan pelayanan yaitu dengan hotel membuat website resmi, hotel membutuhkan departemen khusus SDM hotel, hotel memerlukan SOP terkait penanganan keluhan tamu dan hotel perlu program pelatihan staf (employee training) secara berkala untuk penanganan keluhan tamu.
Pembuatan Keset Srabut Kelapa untuk peningkatan Ekonomi Masyarakat Sidomulyo, Gunungkidul
Authors: Purnomo Sigit , Hidayatullah Ahmad Syuqi , Taufik Yudan , Wijayanti Dela Tri , Nugroho Irfan Adi
Published: February 2024

Purpose − Making coconut fiber doormats with the aim of producing coconut fiber doormats to help reduce coconut waste produced from the coconut processing industry. This supports more sustainable and environmentally friendly processing practices in Sidomulyo Hamlet, Sampang, Gedangsari, Gunungkidul. Coconut fiber is a natural, renewable material. Using coconut fiber to make doormats supports environmental sustainability because it reduces dependence on synthetic materials or plastic..

Method − Activities in the form of training in making coconut fiber mats. The activity process informs the public about how to make coconut fiber mats. Mat products made from coconut fiber help reduce coconut waste produced from the coconut processing industry. This supports more sustainable and environmentally friendly processing practices .

Findings − This activity was participated in by the Sidomulyo Hamlet Community, RT 01, 02, 03 and 04, at the Sidomulyo Hamlet Hall, RT 02. This activity was enthusiastically welcomed by the mothers of Sidomulyo residents who were interested in coconut fiber mats being used to clean floors and other surfaces at home. , office, or public place. The coarse fibers of coconut fiber help lift dust, dirt, and other small particles from surfaces.
Perspektif Belajar dengan Seni Tari Tradisional di Sekolah Menengah Pertama
Authors: Wahyuni Syukur Sri
Published: February 2024

This research aims to determine the perspective of learning with South Sulawesi Traditional Dance in Junior High Schools. This type of research uses qualitative research with an ethnographic approach. The subjects in this research were teachers and students at SMP Negeri 22 Bantimurung. The results of this research show that students who are already at the junior high school level have been equipped with sufficient knowledge to develop so that the learning process will be more challenging for teachers in order to increase students' interest and motivation to learn art in the classroom, one of which is by highlighting traditions and culture. Locally in the South Sulawesi area, namely the basic movements of South Sulawesi traditional dance. So, the role of arts education in junior high schools is an effort to improve students' abilities, especially in developing interests, increasing creative work, as well as knowing regional arts and the values ??contained therein. Through arts education, students are facilitated in the process of growth and development in three domains as learning outcomes, namely, cognitive, affective and psychomotor.
IMPLEMENTASI SISTEM REMUNERASI BADAN LAYANAN UMUM PADA POLITEKNIK PELAYARAN BANTEN
Authors: Adnan  , Amirullah  , Henni Sutryani  , Vidiana Anggeranika
Published: February 2024

penelitian ini bertujuan untuk memberikan gambaran bagaimana implementasi sistem remunerasi Badan Layanan Umum di Politeknik Pelayaran Banten dengan menggunakan teori implementasi yang dikembangkan oleh George Edward III. Pemberian remunerasi ini didasarkan pada capaian kinerja (Key Performance Indicator), yakni dengan menandatangani kontrak kinerja. Jika remunerasi diterapkan dengan benar, diharapkan para pegawai akan meningkatkan kinerjanya sehingga pelayanan terhadap masyarakat akan meningkat menjadi lebih baik. Penelitian ini menggunakan metode penelitian kualitatif dengan model penelitian studi kasus. Hasil penelitian ini antara lain, dalam menerapkan sistem remunerasinya Politeknik Pelayaran Banten telah melakukan langkah-langkah seperti: menyusun tim penyusun remunerasi, penetapan kelas jabatan, penetapan penilaian kinerja perorangan dan proses pencatatan dan pembayaran remunerasi. Hasil penelitian ini juga menunjukkan bahwa realisasi kontrak kerja dalam implementasi sistem remunerasi di lingkungan Poltek Pelayaran Banten merupakan hal utama yang perlu dilaksanakan. Mengingat penilaian kinerja dalam remunerasi didasarkan pada capaian kerja masing-masing karyawan dan dosen. Mengoptimalkan komunikasi melalui media yang mudah diakses seluruh dosen dan karyawan untuk sosialisasi terkait remunerasi baik melalui penyampaian saat apel pagi dan melalui media whatsapp group pegawai. Sosialisasi kebijakan BLU yang mudah diakses para dosen dan karyawan, memberikan kemudahan pada sumber daya manusia di lingkungan Poltek Pelayaran Banten untuk memahami kebijakan remunerasi secara lebih baik. Sedangkan Peningkatan koordinasi antar bidang dan kesesuaian disposisi di Politeknik Pelayaran Banten diperlukan untuk menunjang komunikasi dua arah sebagai landasan efektivitas implementasi sistem remunerasi dalam lembaga agar selalu terjadi kesesuaian antara disposisi yang diberikan dengan nota kebijakan sistem remunerasi BLU.
Optimalisasi penerapan Marpol 73/78 Annex V pada KMP Legundi guna mencegah pencemaran laut
Authors: Nursyamsu  , Mansur Harri Mochamad , Daeli Suratan Samuel
Published: February 2024

Laut merupakan suatu perairan luas yang dalam dan sifatnya penting bagi keberlangsungan umat manusia. Dalam kehidupan sehari-hari, di laut banyak dilakukan kegiatan, salah satunya adalah kegiatan pelayaran oleh kapal-kapal yang bernavigasi. Selain itu, terdapat berbagai regulasi yang mengatur kapal-kapal dalam melakukan pelayaran, salah satunya adalah Marpol 73/78 Annex V yang mengatur mengenai pencegahan pencemaran laut akibat pembuangan limbah dari sisa aktivitas pelayaran kapal. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan objek penelitiannya adalah di KMP Legundi selama 12 bulan untuk mendapatkan data secara langsung. Rute pelayaran KMP Legundi adalah rute Merak-Bakauheni dan sebaliknya. Rute yang dilalui merupakan rute paling ramai sehingga peneliti tertarik untuk melakukan observasi di kapal tersebut. Berdasarkan hasil penelitian didapatkan bahwa penerapan Marpol 73/78 Annex V di KMP Legundi masih belum terimplementasi dengan optimal, khususnya pada kapal penumpang mereka. Dalam hal ini, diperlukan sosialisasi kepada para penumpang, awak kapal maupun tim kebersihan kapal untuk selalu menjaga kebersihan kapal dan lingkungan laut dengan cara tidak membuang sampah sembarangan guna mencegah adanya pencemaran laut. Selain itu, perusahaan diharapkan dapat memberikan aturan khusus terhadap para awaknya dalam menjalankan aturan sesuai dengan Marpol 73/78 Annex V dan dapat memberikan fasilitas yang memadai sebagai fasilitas kebersihan di kapal.
The sea is a vast, deep body of water, and its nature is vital for the survival of humanity. In everyday life, many activities are carried out at sea, including shipping activities by ships that navigate. Apart from that, various regulations regulate ships during shipping, one of which is Marpol 73/78 Annex V, which governs the prevention of marine pollution due to waste disposal from the remainder of ship shipping activities. The method used in this research is descriptive qualitative, with the research object being at KMP Legundi for 12 months to obtain data directly. The KMP Legundi shipping route is the Merak-Bakauheni route and vice versa. The route taken was the busiest, so researchers were interested in making observations on the ship. The research results found that implementing Marpol 73/78 Annex V at KMP Legundi still needs to be optimal, especially on their passenger ships. In this case, outreach to passengers, crew, and ship cleaning teams is required to maintain the ship's cleanliness and the marine environment by not throwing rubbish carelessly to prevent marine pollution. The company is also expected to provide special rules for its crew in carrying out Marpol 73/78 Annex V regulations. It can also provide adequate facilities on the ship, such as cleaning facilities.
MENAs y polarización en medios sociales digitales: la retroalimentación del odio
Authors: Kuric Kardelis Stribor , Sanmartín Ortí Anna , Moraño Ferrer Xavier , Guiteras Vila Xavier
Published: February 2024

El artículo analiza el modo en el que se construye la otredad de Menores Extranjeros No Acompañados en el entorno comunicativo de los medios sociales digitales en España (Twitter, prensa, blogs y foros). Para ello, se han analizado 1,6 millones de conversaciones entre 2010 y 2021 sobre MENAs y bandas juveniles, categorizando las menciones en base a temáticas y dimensionando su volumen. La conversación en torno a bandas se ha mantenido estable a lo largo del período analizado mientras que desde 2018 se ha producido un incremento drástico en el volumen de menciones a MENAs, y la polarización en el discurso es el principal factor explicativo de esta diferencia. Se ha realizado un análisis de 1,3 millones de tweets, definiendo cuatro grandes comunidades de nodos con una narrativa dominante: MENAs o bandas como generadores de conflicto y defensores de MENAs o bandas. El análisis de redes muestra un nivel bajo de polarización en la conversación en torno a bandas mientras que se observa un claro contraste entre el aumento de posturas desfavorables hacia MENAs (sobre todo generadas por la extrema derecha) y el proceso contrario en las posturas de izquierda. En esta polarización, el volumen de la conversación se inclina claramente hacia menciones de los MENAs desde una óptica negativa, pese a las respuestas del grupo de sus defensores.
El discurso de odio hacia las candidatas a la Comunidad de Madrid 2023, sesgo de género y virulencia
Authors: Zamora-Martínez Patricia , Gascón-Vera Patricia , Gómez García Salvador
Published: February 2024

El odio se distingue de la opinión democrática por su intención dañina. La difusión del hate speech (Paz-Rebollo et al., 2020) a través de las redes sociales se caracteriza por su virulencia (Zamora-Medina et al., 2021; Moreno & Morales, 2022), especialmente cuando se dirige hacia la clase política y, en particular, hacia las mujeres que son cuestionadas en clave diferente a sus homólogos masculinos (Soriano, 2019). Esta violencia desencadena una reacción antifeminista (Wilhelm & Joeckel, 2018) caracterizada por su misoginia extrema, reactividad y tendencia a los ataques personales (Bonet-Martín, 2020). De este modo, la agresividad ejercida por los haters contra este colectivo considerado vulnerable está contaminando la esfera pública y afectando negativamente la calidad de las democracias. Partiendo de esta realidad, la presente investigación tratará de identificar y analizar las expresiones de odio dirigidas hacia las cinco mujeres candidatas a la presidencia de la Comunidad de Madrid (Isabel Díaz del Partido Popular, Mónica García de Más Madrid, Rocío Monasterio de Vox, Alejandra Jacinto de Podemos, IU y Alianza Verde, y Aruca Gómez de Ciudadanos) en los comentarios realizados en sus cuentas oficiales de Instagram durante la campaña electoral de mayo de 2023. Además, pretende examinar los discursos de odio que pueden estar relacionados tanto con un sesgo de género femenino como con otros colectivos vulnerables a través de temas como la aporofobia o la xenofobia, entre otros. Los resultados revelan el hecho de que la política desvía el odio hacia las mujeres políticas con gran intensidad (Lacalle et al., 2023).
First-principles calculation of intrinsic point defects and doping performance of MoSi2N4
Authors: Xu Si-Yuan , Zhang Zhao-Fu , Wang Jun , Liu Xue-Fei , Guo Yu-Zheng ,   School of Electrical Engineering and Automation, Wuhan University, Wuhan 430072, China,   The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China,   School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550025, China
Published: February 2024

MoSi2N4 is an emergent two-dimensional (2D) material, which has received much attention because of its excellent performance over semiconductors, including excellent environmental stability and high carrier mobility. However, the formation of intrinsic defects in semiconductors is often inevitable and can significantly affect device performance. By using density functional theory (DFT), we analyze the properties and effects of intrinsic point defects in MoSi2N4. We first confirm the consistency of our results with current experimental data. After that, the formation energy values of twelve native defects reveal that the antisite defect of molybdenum substituting for silicon (MoSi) defect dominates in all intrinsic defects. Under the constraint of overall charge neutrality, self-consistent Fermi level calculations reveal that MoSi2N4 with only intrinsic defects exhibits intrinsic characteristics, highlighting its potential as a semiconductor device material. However, this intrinsic nature contradicts the p-type characteristics observed in two-dimensional MoSi2N4. In the subsequent defect concentrations, we find that both n-type and p-type behavior can be easily realized by doping appropriate impurities without being compensated by native defects. This suggests that the p-type characteristics of MoSi2N4 during growth may result from p-type impurities introduced under non-equilibrium growth conditions or silicon vacancy defects. Our findings not only demonstrate the potential applications of MoSi2N4 in semiconductor devices but also provide valuable guidance for future studying the defect mechanisms of this material.
Regulation of mechanical force on cardiomyocytes beating
Authors: Chen Hui-Yan , Li Luo-Fei , Wang Wei , Cao Yi , Lei Hai ,   National Laboratory of Solid State Microstructure, School of Physics, Nanjing University, Nanjing 210093, China,   School  of Physics, Zhejiang University, Hangzhou 310027, China,   Institute for Advanced Study in Physics, Zhejiang University, Hangzhou 310027, China
Published: February 2024

The mechanical behavior of cardiomyocytes plays an essential role in maintaining life and health. It is traditionally believed that both electrical signals and chemical signals modulate the cardiomyocytes behaviors. Recent discoveries have elucidated that the physical cues of microenvironment can regulate cell activities such as proliferation, spreading, migration, and differentiation. However, there is still limited research on regulating cardiomyocytes beating through mechanical force. Herein we prepare different polyacrylamide gels coated with different cell adhesion ligand proteins to simulate the physical microenvironment of cardiomyocytes. Then the mechanical loading forces are loaded by using a tungsten probe to stretch elastic hydrogels which can emulate the mechanical oscillations induced by the beating of adjacent cardiomyocytes. We investigate the responsive behavior of cardiomyocytes to external mechanical oscillations within various physical microenvironments. Firstly, we load 1 Hz mechanical oscillation on the matrix (E = 11 kPa) with different kinds and concentrations of ligands (0, 5, 20, 100 μg/mL) to stimulate cardiomyocytes and observe their mechanical response behavior. Our findings indicate that all kinds of ligands including Laminin, Fibronectin and Collagen I , can mediate the cardiomyocytes response to extrinsic mechanical oscillatory stimuli, which might be due to distinct mechanisms of mechanical force coupling (Fig. (b)). This suggests that mechanical force signals can regulate the beating of cardiomyocytes through matrix-ligand-cell signaling pathway, thereby inducing intercellular coupled oscillations for rhythmic control of cardiomyocytes. Cardiomyocytes cultured on the matrix coated with 20 μg/mL Laminin show the highest and most stable response fraction. We hypothesize that there exist dual force transduction pathways for Laminin binding to integrin and dystrophin glycoprotein complex (DGC) (Fig. (a)). We further analyze the cardiomyocytes behaviors under mechanical oscillation with different values of substrate stiffness (E = 1.8, 11, 27 kPa) and concentrations of Laminin (0, 5, 20, 100 μg/mL). We find that cardiomyocytes cultured on 1.8 kPa coated with 20 μg/mL Laminin show the highest response fraction (Fig. (c)). Our results demonstrate that the stiffness of substrate, the type and density of cell adhesion ligands, as well as the strength and rhythm of the mechanical signals can synergetically affect the cardiomyocytes responses to external mechanical stimulations, which provides the foundation for understanding the diseases such as cardiac arrhythmias and heart failure following myocardial infarction.
Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3
Authors: Hathaway Nicholas J. , Kim Isaac E. , Young Neeva Wernsman , Hui Sin Ting , Crudale Rebecca , Liang Emily Y. , Nixon Christian P. , Giesbrecht David , Juliano Jonathan J. , Parr Jonathan B. , Bailey Jeffrey A.
Published: February 2024

Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 and phfrp3 genes make parasites undetectable by RDTs. To better understand these deletions, we analyzed 19,289 public whole-genome-sequenced P. falciparum field samples. Pfhrp2 deletion only occurred by chromosomal breakage with subsequent telomere healing. Pfhrp3 deletions involved loss from pfhrp3 to the telomere and showed 3 patterns: no other associated rearrangement with evidence of telomere healing at breakpoint (Asia; Pattern 13 - ); associated with duplication of a chromosome 5 segment containing multidrug-resistant-1 gene (Asia; Pattern 13 - 5 ++ ); and most commonly, associated with duplication of a chromosome 11 segment (Americas/Africa; Pattern 13 - 11 ++ ). We confirmed a 13-11 hybrid chromosome with long-read sequencing, consistent with a translocation product arising from recombination between large interchromosomal ribosome-containing segmental duplications. Within most 13 - 11 ++ parasites, the duplicated chromosome 11 segments were identical to each other. Across parasites, multiple distinct haplotype groupings were consistent with emergence due to clonal expansion of progeny from intrastrain meiotic recombination. Together, these observations suggest negative selection normally removes 13 - 11 ++ pfhrp3 deletions , and specific conditions are needed for their emergence and spread including low transmission, findings that can help refine surveillance strategies.
Mechanism of barotaxis in marine zooplankton
Authors: Bezares Calderón Luis Alberto , Shahidi Réza , Jékely Gáspár
Published: February 2024

Hydrostatic pressure is a dominant environmental cue for vertically migrating marine organisms but the physiological mechanisms of responding to pressure changes remain unclear. Here, we uncovered the cellular and circuit bases of a barokinetic response in the planktonic larva of the marine annelid Platynereis dumerilii. Increased pressure induced a rapid, graded, and adapting upward swimming response due to the faster beating of cilia in the head multiciliary band. By calcium imaging, we found that brain ciliary photoreceptors showed a graded response to pressure changes. The photoreceptors in animals mutant for ciliary opsin-1 had a smaller sensory compartment and mutant larvae showed diminished pressure responses. The ciliary photoreceptors synaptically connect to the head multiciliary band via serotonergic motoneurons. Genetic inhibition of the serotonergic cells blocked pressure-dependent increases in ciliary beating. We conclude that ciliary photoreceptors function as pressure sensors and activate ciliary beating through serotonergic signalling during barokinesis.
Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2
Authors: Nguyen Ai , Zhao Huaying , Myagmarsuren Dulguun , Srinivasan Sanjana , Wu Di , Chen Jiji , Piszczek Grzegorz , Schuck Peter
Published: February 2024

Genetic diversity is a hallmark of RNA viruses and the basis for their evolutionary success. Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the impact of mutations across the spectrum of viable amino acid sequences on the biophysical phenotypes of the highly expressed and multifunctional nucleocapsid protein. We find variation in the physicochemical parameters of its extended intrinsically disordered regions (IDRs) sufficient to allow local plasticity, but also exhibiting functional constraints that similarly occur in related coronaviruses. In biophysical experiments with several N-protein species carrying mutations associated with major variants, we find that point mutations in the IDRs can have nonlocal impact and modulate thermodynamic stability, secondary structure, protein oligomeric state, particle formation, and liquid-liquid phase separation. In the Omicron variant, distant mutations in different IDRs have compensatory effects in shifting a delicate balance of interactions controlling protein assembly properties, and include the creation of a new protein-protein interaction interface in the N-terminal IDR through the defining P13L mutation. A picture emerges where genetic diversity is accompanied by significant variation in biophysical characteristics of functional N-protein species, in particular in the IDRs.
Study of the Physicochemical, Nutritional and Microbiological Quality of Toedo Candies Produced in Ouagadougou, Burkina Faso
Authors: Adama Sawadogo  , Oumar Djibrine Adoum , Cissé Hama , Oussale Blandine O. , Badoun Querène M.A. , Sawadogo Sandaogo , Nikiéma Fulbert , Zongo Cheikna , Tidjani Abdelsalam , Savadogo Aly
Published: February 2024

In Burkina Faso, the pulp of the baobab tree (Adansonia digitata) is mainly used to produce fruit juices or candies called toedo candies. Teodo candies are produced and sold in the markets and popular with the people. However, there is little data on the physicochemical, nutritional and microbiological characteristics of teodo candies produced in Ouagadougou. Thus, this study aimed to evaluate the physicochemical, nutritional and microbiological characteristics of these teodo candies. To carry out the study, 9 samples of toedo candy were taken from different producers in the city of Ouagadougou. The physicochemical and microbiological characteristics were determined by standard methods. Mineral contents were determined by flame spectrometry. The results obtained show that the toedo candies have an average ash content of 1.3±0.21 to 1.9±0.06%, a titratable acidity of 0.131±0.001 to 0.168±0.002%, a pH varying from 3.87±0.10 to 3.91±0.10, a water content from 3.84±0.00 to 16.06±0.14% and a dry matter (DM) content of 84.04±0.14 to 96.16±0.00%. In addition, this study revelead that these samples are rich in micronutrients such as : iron (49.30 to 127.50 mg/100 g DM), magnesium (3.53 to 42.38 mg/100 g DM), zinc (1.37 to 14.92 mg/100 g DM) and calcium (17.60 to 43.30 mg/100 g DM). Microbiological analyzes indicate the presence of total mesophilic aerobic flora (TMAF), yeasts and molds (YM) and coliforms in the samples analyzed with loads of 2.2x103 to 4.9x104 CFU/g, ˂10 to 2.0x102 CFU/g and ˂10 to 5.0x102 CFU/g respectively. For all the germs studied, 11.11% of the samples were of unsatisfactory quality, 44.44% of acceptable quality and 44.44% of satisfactory quality.
Importance of Smart Agriculture and Use of Artificial Intelligence in Shaping the Future of Agriculture
Authors: Nautiyal Chanda Thapliyal , Nautiyal Pankaj , Papnai Gaurav , Mittal Harsh , Agrawal Khusboo , Shivani  , Vishesh  , Nandini Raj
Published: February 2024

India, the second-most populated country globally with 1.4 billion people, faces significant challenges in its agriculture sector, including the need to feed a growing global population, mitigate climate change impacts, and ensure sustainable resource management. To address these challenges, innovative techniques and advanced technologies are required. Modern farming techniques, coupled with artificial intelligence (A.I.), offer promising solutions. Technologies such as drones, biotechnology, genetics, and precision farming can enhance efficiency, productivity, and sustainability. Implementing these approaches can lead to a fiftyfold increase in yield and a 50% reduction in manpower, contributing to increased crop yields, reduced water usage, minimized chemical applications, and improved labor efficiency. Smart agriculture holds the potential to revolutionize the industry, significantly contributing to global food security and the preservation of natural resources.
Comparative Antimicrobial Activity of Lactobacillus acidophilus and Lactobacillus rhamnosus on Clinically Isolated Escherichia coli: An In vitro Study
Authors: Kuriakose Nithyamol , Raj Ananthu , Anil Anju , Azhar M M  , Sathar Sajmi , Anagha S  , Harish Kumar K S
Published: February 2024

Aim: The aim of present study is to evaluate the comparative antimicrobial activity of Lactobacillus acidophilus and Lactobacillus rhamnosus on clinical isolates of Escherichia coli.

Study Design:  Cross-sectional observational study.

Place and Duration of Study: This study was conducted in Department of Medical Microbiology, School of Medical Education between January 2023 to September 2023.

Methodology: A total of 100 E. coli isolates collected from various diagnostic laboratories were included in the sample population and the prevalence of XDR, MDR, and non MDR isolates among them were determined by Kirby-Bauer disk diffusion method. The inhibitory activity of untreated and treated (pH adjusted) suspension of standard strains of L. acidophilus and L. rhamnosus on E. coli were determined by agar overlay method and the data was statistically analysed using ANOVA single-factor.

Results: The antimicrobial activity was confirmed for untreated and treated suspension of Lactobacillus spp. by measuring the zone of inhibition surrounding E. coli strains spotted on MRS medium but treated suspension exerted greater inhibitory activity than untreated suspensions of both Lactobacillus spp. and among the treated suspension L. rhamnosus exhibit greater inhibitory activity. Statistical analysis of this data using ANOVA single-factor was found to be not significant (P >0.05), that is treated suspension of both L. acidophilus and L. rhamnosus has the independent activity against E. coli. While untreated suspensions of both L. acidophilus and L. rhamnosus was significant (P =0.03), that is untreated suspension of L. rhamnosus (mean inhibition of 12.19 mm) has greater inhibitory activity than untreated cell cultures of L. acidophilus (mean inhibition of 11.39 mm).

Conclusion: This result, disclosed that even if both Lactobacillus spp. exhibit antimicrobial activity against E. coli, L. rhamnosus showed greater inhibition than L. acidophilus. The study suggested the use probiotic Lactobacillus as a biotherapeutic in antibiotic resistant E. coli infection and should be further studied for their human health benefits.
The Transformative Power of Artificial Intelligence in Banking Client Service
Authors: Maseke Bernardus Franco
Published: February 2024

The financial industry is experiencing a paradigm shift driven by Artificial Intelligence (AI). This manuscript delves into the profound impact of AI on banking client services, exploring how it revolutionizes the industry. As banks strive to elevate customer experiences, reduce operational costs, and maintain their competitive edge, AI emerges as a critical enabler. This study employs a mixed-method research approach to comprehensively investigate the impact of Artificial Intelligence (AI) on client service in the banking sector. To test the hypothesis, we conducted a regression analysis with customer satisfaction as the dependent variable and AI integration and operational efficiency as independent variables. The results demonstrate a statistically significant relationship between AI integration and customer satisfaction (β = 0.632, p < 0.001). The research reveals that clients perceive a moderate level of AI integration into banking operations, with room for further enhancement. Notably, clients express high satisfaction with AI-enhanced services, underscoring its positive influence, as corroborated by existing literature. Recommendations emphasize strategic actions to maximize AI's potential: augmenting AI integration beyond chatbots to encompass predictive analytics and fraud detection, initiating customer education programs to familiarize clients with AI-powered services, prioritizing data privacy and security measures, and providing comprehensive staff training in AI ethics and customer interaction. In conclusion, "The Transformative Power of Artificial Intelligence in Banking Client Service" serves as a timely guide for banking professionals, policymakers, and researchers eager to harness AI's potential for the betterment of the financial industry and its clients. This research paints a compelling picture of how AI is reshaping the future of banking, offering insights into its transformative capacity. As AI continues to evolve, this manuscript provides a roadmap for financial institutions, highlighting the need to adapt, collaborate, and strategize effectively to thrive in the rapidly changing landscape.
An aggression machine v. determinants in reactive aggression revisited
Authors: Juujärvi Petri , Kooistra Libbe , Kaartinen Jukka , Pulkkinen Lea
Published: October 2004

The relations between reactive aggression, situational cues, and emotion regulation were examined by means of the Pulkkinen Aggression Machine (PAM) task. In the PAM, provocation and response were systematically varied under two conditions: the impulsive aggression condition and the controlled aggression condition. In the impulsive condition, no information about the attacker was provided, while in the controlled condition the attackers were specified in terms of sex, age, and physical strength. The task was administered to 109 children aged 8 to 13 years. Boys (n = 61) and girls (n = 48), as well as subgroups of Adjusted (n = 67) and Maladjusted (n = 26) children were compared. The results confirmed earlier findings showing that there is a strong relationship between attack and response intensity. However, this relationship was consistently modified by the effects of situation and personality‐related variables. This meant that, while for the impulsive condition response intensity was closely tied to stimulus intensity, in the controlled condition this effect was modulated by the characteristics of the opponent: the more equal the opponent the stronger the retaliations displayed. The Maladjusted children reacted more intensively in the impulsive condition and to minor provocation in the controlled condition than the Adjusted children. This suggests that the intensity of the elicited aggression in the Maladjusted group was particularly dependent on contextual rather than internal control. Aggr. Behav. 27:430–445, 2001. © 2001 Wiley‐Liss, Inc.
Highly Active and Selective Platinum(0)‐Carbene Complexes. Efficient, Catalytic Hydrosilylation of Functionalised Olefins
Authors: Markó István E. , Stérin Sébastien , Buisine Olivier , Berthon Guillaume , Michaud Guillaume , Tinant Bernard , Declercq Jean‐Paul
Published: October 2004

Readily available N‐heterocyclic platinum‐carbene complexes1are highly efficient catalysts for the regioselective hydrosilylation of alkenes. These novel organometallics tolerate a wide range of functional and protecting groups, can be stored for prolonged periods of time and are particularly active (TON>106).
Chemoselective Hydrogenation of α,β‐Unsaturated Nitriles
Authors: Kukula Pavel , Studer Martin , Blaser Hans‐Ulrich
Published: October 2004

The chemoselective hydrogenation of cinnamonitrile to 3‐phenylallylamine proceeds with up to 80% selectivity at conversions of >90% with Raney cobalt and up to 60% selectivity with Raney nickel catalysts. Best results were obtained with a doped Raney cobalt catalyst (RaCo/Cr/Ni/Fe 2724) in ammonia saturated methanol at 100 °C and 80 bar. Major problems are the formation of hydrocinnamonitrile and of secondary amines, and overreduction to 3‐phenylpropylamine. Important parameters are the catalyst type and composition, the solvent type and the presence and concentration of ammonia. The catalytic system tolerates functional groups like OH, OMe, Cl, CO, but not aromatic nitro groups. Preliminary experiments indicate that other unsaturated nitriles with di‐ or trisubstituted CC bonds are also suitable substrates.
Synthesis, Catalytic Activity in Oxidation Reactions, and Recyclability of Stable Polyoxometalate‐Centred Dendrimers
Authors: Nlate Sylvain , Astruc Didier , Neumann Ronny
Published: October 2004

Nine‐ and 27‐armed dendrimers with a peroxophosphotungstate core were synthesized by an ionic‐bonding approach and used as air‐stable, recoverable catalysts for oxidation reactions using hydrogen peroxide.
Estimating strategic price response using cointegration analysis: The case of the domestic black and herbal tea industries
Authors: Vickner Steven S. , Davies Stephen P.
Published: October 2004

In this article we develop a vector error correction model using weekly, point‐of‐purchase scanner data to investigate multivariate pricing relationships among brands competing in the domestic black and herbal tea industries. Johansen's likelihood ratio test established the prices of Bigelow black tea and Celestial Seasonings herbal tea were cointegrated; hence, the pricing decisions of the largest firms in each respective tea market were not unrelated. The black tea prices of Bigelow and Twining, the two largest firms in the black tea market, were cointegrated as well. The cointegrating vectors, speeds of adjustment, and impulse response function analysis provide unique insights into the direction, magnitude, and speed of price response in these value‐added, agricultural product markets. [EconLit citations: M100, L200, L660] © 2002 Wiley Periodicals, Inc.
Molecular‐pathogenetic classification of genetic disorders of the skeleton
Authors: Superti‐Furga Andrea , Bonafé Luisa , Rimoin David L.
Published: October 2004

Genetic disorders of the skeleton (skeletal dysplasias and dysostoses) are a large and disparate group of diseases whose unifying features are malformation, disproportionate growth, and deformation of the skeleton or of individual bones or groups of bones. To cope with the large number of different disorders, the “Nosology and Classification of the Osteochondrodysplasias,” based on clinical and radiographic features, has been designed and revised periodically. Biochemical and molecular features have been partially implemented in the Nosology, but the rapid accumulation of knowledge on genes and proteins cannot be easily merged into the clinical–radiographic classification. We present here, as a complement to the existing Nosology, a classification of genetic disorders of the skeleton based on the structure and function of the causative genes and proteins. This molecular–pathogenetic classification should be helpful in recognizing metabolic and signaling pathways relevant to skeletal development, in pointing out candidate genes and possible therapeutic targets, and more generally in bringing the clinic closer to the basic science laboratory and in promoting research in this field. © 2002 Wiley‐Liss, Inc.
Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments
Authors: Unger Sheila , Hecht Jacqueline T.
Published: October 2004

Pseudoachondroplasia (PSACH) (OMIM#177170) and multiple epiphyseal dysplasia (MED) are separate but overlapping osteochondrodysplasias. PSACH is a dominantly inherited disorder characterized by short‐limb short stature, loose joints, and early‐onset osteoarthropathy. The diagnosis is based on characteristic clinical and radiographic findings. Only mutations in the cartilage oligomeric matrix protein (COMP) gene have been reported in PSACH, and all family studies have been consistent with linkage to theCOMPlocus on chromosome 19. Multiple epiphyseal dysplasia (MED) is a relatively mild chondrodysplasia but like PSACH, MED causes early‐onset joint degeneration, particularly of the large weight‐bearing joints. Given the clinical similarity between PSACH and MED, it was not surprising that the first MED locus identified was theCOMPgene (EDM1). Mutations causing MED have now been identified in five other genes (COL9A1, COL9A2, COL9A3, DTDST, andMATN3), making MED one of the most genetically heterogeneous disorders. This article reviews the clinical features of PSACH and MED, the known mutations, and the pathogenetic effect ofCOMPmutations on the cartilage extracellular matrix. © 2002 Wiley‐Liss, Inc.
A family‐based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia
Authors: Murad I. , Kremer I. , Dobrusin M. , Muhaheed M. , Bannoura I. , Müller D.J. , Schulze T.G. , Reshef A. , Blanaru M. , Gathas S. , Tsenter V. , Rietschel M. , Belmaker R.H. , Maier W. , Ebstein Richard P.
Published: October 2004

The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi‐square = 0.00, NS). © 2001 Wiley‐Liss, Inc.
Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population‐based sample of female twins
Authors: Foley Debra L. , Thacker Leroy R. , Aggen Steven H. , Neale Michael C. , Kendler Kenneth S.
Published: October 2004

The association between pregnancy and perinatal complications (PPCs) and risks for adult psychiatric disorders other than psychoses has received relatively limited attention. In this study, we aim to characterize the associations between PPCs and risks for anxiety, affective, substance use, and eating disorders in a population‐based sample of twins. Personal interviews were conducted with 1,806 female twin subjects to assess their lifetime history of alcoholism, anorexia nervosa, bulimia nervosa, generalized anxiety disorder, major depression, panic disorder, simple phobias, and social phobias. PPCs were retrospectively assessed at personal interview with the subject's parents. The associations between PPCs and risks for psychiatric disorders are characterized using logistic regression. In this sample of twins, gestational age is associated with a significantly increased risk for anorexia nervosa and pregnancy complications are associated with a significantly increased risk for both anorexia nervosa and bulimia nervosa. Pregnancy and perinatal complications may be associated with an increased risk for eating disorders in women. © 2001 Wiley‐Liss, Inc.