bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing an acceptable and fair carbon tax: The role of mental accounting
Authors: Mus Mathilde , Mercier Hugo , Chevallier Coralie
Published: October 2023

Despite its potential for curbing greenhouse gas emissions, carbon taxation encounters strong public resistance. However, acceptability depends on how tax revenues are used. We test the hypothesis that mental accounting theory can both explain systematic patterns in citizens’ preferences, such as the support for environmental earmarking, and help design a carbon tax scheme that is both acceptable and fair. Across six experiments conducted in the United Kingdom and in France (Ntotal = 7100), we show that: (a) There is an acceptability boost when the use of tax revenues matches the tax domain thematically (e.g., allocating carbon tax revenues to green projects), as demonstrated by an interaction effect between the tax domain and the expenditure domain on the level of tax support. This result is consistent with the use of a mental accounting heuristic, by which people create mental budgets where the origin of revenues is matched thematically with their domain of use. (b) Carbon tax acceptability varies with the proportion of tax revenues earmarked for green projects. (c) A mixed carbon tax scheme, in which most revenues are earmarked for green projects and the rest is redistributed to low-income households to be spent on sustainable expenses, receives most support among the tested options. We also demonstrate the robustness of the mental accounting heuristic in two ways: by showing that the preference for environmental earmarking of carbon taxes is observed across all relevant subsections of the population, and that mental accounting also appears to shape preferences for health-related earmarking of tobacco taxes, and social-related earmarking of inheritance taxes.
Environmental DNA metabarcoding reveals distinct fish assemblages supported by seagrass (Zostera marina and Zostera pacifica) beds in different geographic settings in Southern California
Authors: Waters Tanner , Gold Zachary , Obaza Adam , Ambrose Richard F. , Eagle Robert A.
Published: October 2023

Seagrass beds are disappearing at a record pace despite their known value to our oceans and coastal communities. Simultaneously, our coastlines are under the constant pressure of climate change which is impacting their chemical, physical and biological characteristics. It is thus pertinent to evaluate and record habitat use so we can understand how these different environments contribute to local biodiversity. This study evaluates the assemblages of fish found at five Zostera beds in Southern California using environmental DNA (eDNA) metabarcoding. eDNA is a powerful biodiversity monitoring tool that offers key advantages to conventional monitoring. Results from our eDNA study found 78 species of fish that inhabit these five beds around Southern California representing embayment, open coastal mainland and open coastal island settings. While each bed had the same average number of species found throughout the year, the composition of these fish assemblages was strongly site dependent. There were 35 fish that were found at both open coast and embayment seagrass beds, while embayment seagrass sites had 20 unique fish and open coast sites had 23 unique fish. These results demonstrate that seagrass fish assemblages are heterogenous based on their geographic positioning and that marine managers must take this into account for holistic conservation and restoration efforts.
Based on the multi-scale information sharing network of fine-grained attention for agricultural pest detection
Authors: Linfeng Wang , Yong Liu , Jiayao Liu , Yunsheng Wang , Shipu Xu
Published: October 2023

It is of great significance to identify the pest species accurately and control it effectively to reduce the loss of agricultural products. The research results of this project will provide theoretical basis for preventing and controlling the spread of pests and reducing the loss of agricultural products, and have important practical significance for improving the quality of agricultural products and increasing the output of agricultural products. At the same time, it provides a kind of effective prevention and control measures for farmers, so as to ensure the safety and health of crops. Because of the slow speed and high cost of manual identification, it is necessary to establish a set of automatic pest identification system. The traditional image-based insect classifier is mainly realized by machine vision technology, but because of its high complexity, the classification efficiency is low and it is difficult to meet the needs of applications. Therefore, it is necessary to develop a new automatic insect recognition system to improve the accuracy of insect classification. There are many species and forms of insects, and the field living environment is complex. The morphological similarity between species is high, which brings difficulties to the classification of insects. In recent years, with the rapid development of deep learning technology, using artificial neural network to classify pests is an important method to establish a fast and accurate classification model. In this work, we propose a novel convolutional neural network-based model (MSSN), which includes attention mechanism, feature pyramid, and fine-grained model. The model has good scalability, can better capture the semantic information in the image, and achieve more accurate classification. We evaluated our approach on a common data set: large-scale pest data set, PlantVillage benchmark data set, and evaluated model performance using a variety of evaluation indicators, namely, macro mean accuracy (MPre), macro mean recall rate (MRec), macro mean F1-score (MF1), Accuracy (Acc) and geometric mean (GM). Experimental results show that the proposed algorithm has better performance and universality ability than the existing algorithm. For example, on the data set, the maximum accuracy we obtained was 86.35%, which exceeded the corresponding technical level. The ablation experiment was conducted on the experiment itself, and the comprehensive evaluation of the complete MSSN(scale 1+2+3) was the best in various performance indexes, demonstrating the feasibility of the innovative method in this paper.
Efficacy of myofascial induction compared with its simulation on joint amplitude in people with axial spondylarthritis: Protocol of a randomized controlled clinical trial
Authors: Sánchez Vera María Alejandra , Jaimes Fernández Diego Alejandro , Schleip Robert
Published: October 2023

Background

Axial spondyloarthritis (AxSpA) produces structural changes that cause alterations in body functions. One tissue that seems to have a predictive role in the etiology and progression of the disease is the soft tissue, particularly the fascia. However, little is known about the use of myofascial induction in people with AxSpA, and clinical evidence from physiotherapy regarding potential strategies is limited.

Objective

To evaluate the efficacy of myofascial induction compared with its simulation on joint amplitude in people with AxSpA.

Methods

In this randomized controlled parallel superiority clinical trial, 84 people with an AxSpA diagnosis confirmed by a rheumatologist will be randomly assigned to groups: the experimental group or the control group. The experimental group will receive myofascial induction, and the control group will undergo a simulation of the technique. Both groups will receive an examination session and six intervention sessions twice per week for three weeks. A baseline follow-up will be performed immediately after the intervention and four weeks after treatment.

Conclusion

The results of this study may contribute to a better understanding of the efficacy of myofascial induction for joint mobility in people with AxSpA. The implications of these results have a potential transformative effect on the understanding, analysis, evaluation, and physiotherapeutic treatment of this health condition.

Trial registration

ClinicalTrials.gov NCT04424589. Registered 11 June 2020.
Technical standardization and total factor productivity in innovation-driven development: Evidence from China
Authors: Wang Shuo , Zheng Yueping , Wang Qian
Published: October 2023

Innovation drive differs from investment drive and resource drive in that it focuses on knowledge and skills to promote productivity growth. By integrating technical standards within the framework of an innovation-driven development system in this work, theoretical implications for this development strategy may be revealed. Following our theoretical study, we built a PECM utilizing China’s inter-provincial panel data from 2007 to 2020 to investigate the long and short-term relationships between standardization, R&D, and innovation-driven development. The following are the key findings: First, both standardization and R&D are the nation’s critical engines of innovation-driven development. Second, standardization has the greatest impact on TFP through improving technical efficiency, whereas R&D drives both technical development and technical efficiency improvement. Third, while the influence of technical standard drafters’ production scale on scale efficiency was insignificant from 2007 to 2013, it became substantial after 2014 with China’s macroeconomic reform of "transforming the mode and changing the structure."
Cognitive modeling for understanding interactions between people and decision support tools in complex and uncertain environments: A study protocol
Authors: Molina Isaac , Molina-Perez Edmundo , Sobrino Fernanda , Tellez-Rojas Mario , Serra-Barragan Luis , Castellón-Flores Alejandra Mitzi , Orozco Yessica , de Unanue Adolfo , Rojas-Iturria Fatima
Published: October 2023

Background

Recent advances in Computational Intelligence Tools and the escalating need for decision-making in the face of complex and uncertain phenomena like pandemics, climate change, and geopolitics necessitate understanding the interaction between these tools and human behavior. It is crucial to efficiently utilize the decision-makers cognitive resources in addressing specific problems.

Methods

The main goal of this present protocol is to describe the effect that CITs (Computational Intelligence Tools) have on decisions made during complex and uncertain situations. It is an exploratory study with a mixed methodology. Solomon’s group experiment design includes a narrative analysis of cognitive features such as integrative complexity (IC), cognitive flexibility (CF), and fluid intelligence (FI). Additionally, measures of neural activity (NA), physiological measures (PM), and eye-tracking data (ET) will be collected during the experimental session to examine the marginal impact of these processes on decision outcomes (DO) and their relation to CIT capabilities. To achieve this objective, 120 undergraduate and graduate students involved in decision-making will participate as subjects. The approximate duration of the study will be 2 years. Strict adherence to the relevant ethical considerations will be maintained during the performance of the experimental tasks.

Discussion

The study will provide valuable information on CITs’ effect on decision-making under complex and uncertain contexts. This will help to better understand the link between technology and human behavior, which has important implications. CIT designers can use future results and at the same time, it will be possible to understand cognitive, behavioral, physiological processes, and even the subjective assessment of individuals when they use technological tools to solve a problem.
The effect of thyme herb in diets for fattening pigs on their growth performance and health
Authors: Czech Anna , Klimiuk Kamila , Sembratowicz Iwona
Published: October 2023

To enrich pork with valuable n-3 PUFA, it is common practice to include flaxseeds in the swine diet. However, due to the high susceptibility of these acids to oxidation, this treatment requires an additional supply of antioxidants. Thyme herb can be used for this purpose, which in addition to high antioxidant activity is characterized by numerous health-promoting properties. The present study aimed at evaluating the impact of the inclusion of 1% and 3% of thyme herb in mixtures with 4% of extruded flaxseeds as a source of n-3 PUFA on the performance results and health status of fatteners. The experiment was carried out on 120 weaners with an initial body weight of about 30 kg and kept until the end of fattening. They were divided into three experimental groups of 40 animals each (5 pens with 8 pigs in each). The control group (C) consisted of pigs receiving a base mixture with 4% of extruded flaxseeds. In the experimental groups, an additional 1% (T1) or 3% (T3) of thyme herb was added to the mixture. By supplementing the diet with 3% of thyme, an increase in average daily weight gain (P = 0.001) and a better feed conversion ratio (P < 0.001) were obtained. This could be the result of an improvement in the small intestine histology (greater villus height–P < 0.001) and better digestibility of basic nutrients (especially crude protein–P < 0.05) found in experimental animals. In addition to these effects, thyme herb supplementation contributed to the stimulation of immune mechanisms (increase in the number of WBC–P ≤ 0.05; plasma IgA ‐ P < 0.05 and IgG–P < 0.005, and the level of lysozyme–P < 0.05). The obtained results indicate the advisability of the use of thyme as a feed additive beneficially influencing the health and performance results in pigs. The obtained results indicate the advisability of the use of thyme as a feed additive beneficially influencing the health and performance results in pigs.
Not simply a matter of parents—Infants’ sleep-wake patterns are associated with their regularity of eating
Authors: Mühlematter Christophe , Nielsen Dennis S. , Castro-Mejía Josue L. , Brown Steven A. , Rasch Björn , Wright Kenneth P. , Walser Jean-Claude , Schoch Sarah F. , Kurth Salome
Published: October 2023

In adults there are indications that regular eating patterns are related to better sleep quality. During early development, sleep and eating habits experience major maturational transitions. Further, the bacterial landscape of the gut microbiota undergoes a rapid increase in complexity. Yet little is known about the association between sleep, eating patterns and the gut microbiota. We first hypothesized that higher eating regularity is associated with more mature sleep patterns, and second, that this association is mediated by the maturational status of the gut microbiota. To test this hypothesis, we performed a longitudinal study in 162 infants to assess actigraphy, diaries of sleep and eating times, and stool microbiota composition at ages 3, 6 and 12 months. To comprehensively capture infants’ habitual sleep-wake patterns, 5 sleep composites that characterize infants’ sleep habits across multiple days in their home environment were computed. To assess timing of eating habits, we developed an Eating Regularity Index (ERI). Gut microbial composition was assessed by 16S rRNA gene amplicon sequencing, and its maturation was assessed based on alpha diversity, bacterial maturation index, and enterotype. First, our results demonstrate that increased eating regularity (higher ERI) in infants is associated with less time spent awake during the night (sleep fragmentation) and more regular sleep patterns. Second, the associations of ERI with sleep evolve with age. Third, the link between infant sleep and ERI remains significant when controlling for parents’ subjectively rated importance of structuring their infant’s eating and sleeping times. Finally, the gut microbial maturational markers did not account for the link between infant’s sleep patterns and ERI. Thus, infants who eat more regularly have more mature sleep patterns, which is independent of the maturational status of their gut microbiota. Interventions targeting infant eating rhythm thus constitute a simple, ready-to-use anchor to improve sleep quality.
Study on the mechanism of Shenkang injection in the treatment of chronic renal failure based on the strategy of "Network pharmacology—Molecular docking—Key target validation"
Authors: Zhou Lin , Wang Xiaohui , Sun Zhi , Bao Xiaoyue , Xue Lianping , Xu Zhanmei , Dong Pengfei , Xia Jinlan
Published: October 2023

Objective

To explore the potential mechanism of Shenkang injection (SKI) in the treatment of chronic renal failure based on network pharmacology and molecular docking technology, and to verify the core targets and key pathways by using the renal failure model.

Methods

The active components and targets of Shenkang injection were retrieved by TCMSP database, and the disease related targets were obtained by OMIM, GeneCards and other databases. Then, the intersection was obtained, and were imported into String database for PPI analysis. After further screening of core targets, GO and KEGG analysis were performed. Autodock software was used to predict the molecular docking and binding ability of the selected active ingredients and core targets. Chronic renal failure (CRF) model was established by adenine induction in rats, and the pathological observation of renal tissues was conducted. Meanwhile, the effects of Shenkang injection and its active components on core targets and pathways of renal tissues were verified.

Results

The results of network pharmacology showed that the main components of Shenkang injection might be hydroxysafflor yellow A (HSYA)、tanshinol、rheum emodin、Astragaloside IV. Through enrichment analysis of core targets, it was found that Shenkang injection may play an anti-chronic renal failure effect through PI3K-Akt signaling pathway. Molecular docking results showed that the above pharmacodynamic components had strong binding ability with the target proteins PI3K and Akt. The results of animal experiments showed that renal function indexes of Shenkang injection group and pharmacodynamic component group were significantly improved compared with model group. HE staining results showed that the pathological status of the kidney was significantly improved in SKI and pharmacodynamic component treatment groups. Immunohistochemical results showed that the renal fibrosis status was significantly reduced in SKI and pharmacodynamic component treatment groups. q-RTPCR and WB results showed that the expression levels of PI3K and Akt were significantly decreased in the treatment groups (P< 0.05).

Conclusions

Shenkang injection may inhibit PI3K-Akt signaling pathway to play an anti-chronic renal failure role through the pharmacodynamic component hydroxysafflor yellow A (HSYA), tanshinol, rheum emodin, Astragaloside IV.
Feeding styles and adiposity in children of 6 months– 5 years of age: Protocol for a systematic review and meta- analysis
Authors: Haridas Divya Nair , Schayck Onno C. P. van , Babu Giridhar R. , Nair N. Sreekumaran , Shriyan Prafulla
Published: October 2023

Obesity in children is a major public health concern due to the increased risk of developing adverse health outcomes in their future, and disability in adulthood. The existing systematic reviews on the topic are limited in scope, focusing solely on high-income countries and children aged 4–12 years. Hence, we propose to conduct a systematic review and meta-analysis to understand, how exposure to authoritative feeding style versus authoritarian, indulgent, uninvolved compare in terms of its association with adiposity in children aged 6 months to 5 years. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines were followed for ensuring the completeness of the protocol. Case-control and cohort studies will be included. Searches will be done using electronic databases viz. PubMed, Ovid EMBASE, PsycINFO and Web of Science. Grey literature will be searched using OpenGrey and Grey Literature Report. We will only include quantitative studies using the developed search strategy. For categorical outcomes, relative risks, odds ratios, and hazard ratios with confidence intervals and for continuous outcomes mean difference with confidence intervals will be used. Risk of Bias In Non-randomized Studies- of Exposure (ROBINS-E) will be used for the evaluation of risk of bias in the individual observational studies. Considering the inherent variability in the observational studies, random effects meta-analysis will also be conducted. If between-study heterogeneity exists, a subgroup analysis based on low and middle-income countries vs. high income countries will be conducted. If the data is not suitable for combining quantitatively, a narrative synthesis will be undertaken. We propose to identify publication bias by using contour-enhanced funnel plots and “trim and fill” method. Outcome reporting bias will be ascertained by comparing the outcomes published in the protocol and the published report. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system will be used to understand the confidence we can have on the effect estimates.

Registration: This protocol has been registered in International Prospective Register of Systematic Reviews (PROSPERO) on 13 March 2023 with registration number CRD42023356014.
Fetal death and its association with indicators of social inequality: 20-year analysis in Tacna, Peru
Authors: Copaja-Corzo Cesar , Gomez-Colque Sujey , Vilchez-Cornejo Jennifer , Hueda-Zavaleta Miguel , Taype-Rondan Alvaro
Published: October 2023

Objective

The aim of this study was to evaluate the rates of fetal mortality in a Peruvian hospital between 2001 and 2020 and to investigate the association of indicators of social inequality (such as access to prenatal care and education) with fetal mortality.

Methodology

We conducted a retrospective cohort study, including all pregnant women who attended a Peruvian hospital between 2001 and 2020. We collected data from the hospital’s perinatal computer system. We used Poisson regression models with robust variance to assess the associations of interest, estimating adjusted relative risks (aRR) and their 95% confidence intervals (95% CI).

Results

We analyzed data from 67,908 pregnant women (median age: 26, range: 21 to 31 years). Of these, 58.3% had one or more comorbidities; the most frequent comorbidities were anemia (33.3%) and urinary tract infection (26.3%). The fetal mortality ratio during the study period was 0.96%, with the highest rate in 2003 (13.7 per 1,000 births) and the lowest in 2016 (6.1 per 1,000 births), without showing a marked trend. Having less than six (aRR: 4.87; 95% CI: 3.99–5.93) or no (aRR: 7.79; 6.31–9.61) prenatal care was associated with higher fetal mortality compared to having six or more check-ups. On the other hand, higher levels of education, such as secondary education (aRR: 0.73; 0.59–0.91), technical college (aRR: 0.63; 0.46–0.85), or university education (aRR: 0.38; 0.25–0.57) were associated with a lower risk of fetal death compared to having primary education or no education. In addition, a more recent year of delivery was associated with lower fetal mortality.

Conclusion

Our study presents findings of fetal mortality rates that are comparable to those observed in Peru in 2015, but higher than the estimated rates for other Latin American countries. A more recent year of delivery was associated with lower fetal mortality, probably due to reduced illiteracy and increased access to health care between 2000 and 2015. The findings suggest a significant association between indicators of social inequality (such as access to prenatal care and education) with fetal mortality. These results emphasize the critical need to address the social and structural determinants of health, as well as to mitigate health inequities, to effectively reduce fetal mortality.
ComsystanJ: A collection of Fiji/ImageJ2 plugins for nonlinear and complexity analysis in 1D, 2D and 3D
Authors: Ahammer Helmut , Reiss Martin A. , Hackhofer Moritz , Andronache Ion , Radulovic Marko , Labra-Spröhnle Fabián , Jelinek Herbert Franz
Published: October 2023

Complex systems such as the global climate, biological organisms, civilisation, technical or social networks exhibit diverse behaviours at various temporal and spatial scales, often characterized by nonlinearity, feedback loops, and emergence. These systems can be characterized by physical quantities such as entropy, information, chaoticity or fractality rather than classical quantities such as time, velocity, energy or temperature. The drawback of these complexity quantities is that their definitions are not always mathematically exact and computational algorithms provide estimates rather than exact values. Typically, evaluations can be cumbersome, necessitating specialized tools. We are therefore introducing ComsystanJ, a novel and user-friendly software suite, providing a comprehensive set of plugins for complex systems analysis, without the need for prior programming knowledge. It is platform independent, end-user friendly and extensible. ComsystanJ combines already known algorithms and newer methods for generalizable analysis of 1D signals, 2D images and 3D volume data including the generation of data sets such as signals and images for testing purposes. It is based on the framework of the open-source image processing software Fiji and ImageJ2. ComsystanJ plugins are macro recordable and are maintained as open-source software. ComsystanJ includes effective surrogate analysis in all dimensions to validate the features calculated by the different algorithms. Future enhancements of the project will include the implementation of parallel computing for image stacks and volumes and the integration of artificial intelligence methods to improve feature recognition and parameter calculation.
An exploration of proactive health oriented symptom patterns in patients undergoing percutaneous coronary intervention with stent implantation: A mixed-methods study protocol
Authors: Wang Qi , Xu Chaoyue , He Zhiqing , Zou Ping , Yang Jing , Huang Yanjin
Published: October 2023

Background

Coronary Heart Disease (CHD) is one of the most prevalent chronic diseases worldwide. Currently, percutaneous coronary intervention (PCI) with stent implantation is the main clinical treatment for CHD, and patients can achieve better outcomes after stenting. However, adverse cardiovascular events continue to recur, ultimately failing to yield good results. Several symptoms exist after stenting and are associated with health outcomes. Little is known about the symptom patterns of patients during the different postoperative periods. Therefore, this study aims to explore the dynamics of symptoms and clarify the experiences of post-stenting in patients during different periods, which may help the delivery of more specific patient management and improve survival outcomes in the future.

Methods

A mixed method (quantitative/qualitative) design will be adopted. Longitudinal research, including surveys regarding three different periods, will be sued to describe the symptom patterns of patients undergoing PCI with stent implantation, clarifying their focused symptom problems during different time periods or in populations with different features. Qualitative individual interviews aim to understand the feelings, experiences, opinions, and health conditions of patients post-stenting, which can explain and supplement quantitative data. Quantitative data will be analyzed using descriptive statistics, latent class analysis (LCA), and latent translation analysis (LTA). Qualitative data will be analyzed using content analysis.

Discussion

This study is the first study to explore the symptom patterns and experiences of patients in various domains after stent implantation using a novel design including quantitative and qualitative methods, which will help the delivery of more specific patient management, reduce the recurrence of adverse cardiovascular events, and improve survival outcomes in the future. It is also meaningful to use PROMIS profile-57 to help patients to proactively focus on their health problems, promote health literacy, and incorporate active patient participation into health management, which is a successful transition from passive medical treatment to active management.
Tuberculosis screening for pediatric household contacts in India: Time to adapt newer strategies under the National TB Elimination Programme!
Authors: Chawla Kiran , Burugina Nagaraja Sharath , Siddalingaiah Nayana , Sanju Chidananda , Kumar Uday , Shenoy Vishnu Prasad , Shastri Suresh , Singarajipur Anil
Published: October 2023

Introduction

The study aimed to evaluate the effectiveness of screening pediatric household contacts (under the age of 15 years) for tuberculosis (TB) in India through verbal screening, tuberculin skin testing, and chest radiography at intervals of 0, 3, 6, 9, and 12 months. The study also aimed to determine the proportion of contacts who tested positive for TB and to describe the challenges in implementing regular follow-up. Current National TB Elimination Programme (NTEP) guidelines only require verbal screening for contacts under 6 years old at TB treatment initiation. The study aimed to fill this knowledge gap and provide valuable insights for improving TB screening in pediatric household contacts in India.

Methods

The study was conducted in two districts of Karnataka, India from 2021 to 2022, and utilized a cohort study design to enroll contacts of index tuberculosis (TB) cases diagnosed under the National TB Elimination Programme (NTEP). Participants were followed up at regular intervals for one year to evaluate the effectiveness of TB screening in pediatric household contacts.

Results

In this study, 686 pediatric household contacts were enrolled and screened for tuberculosis (TB) using verbal symptom screening, tuberculin skin testing (TST), and chest radiography. Projected figures estimated that 0.8%, 42%, and 4% of contacts would test positive for symptomatic screening, TST, and chest radiography, respectively. TB cases were detected in 2.91% (1.84–4.38) of contacts, with females above 6 years of age having a 22% higher risk of contracting the infection than males above 6 to < 15 years. However, not all cases were subjected to TST and chest radiography. The primary reason for not investigating child contact for TB was their reported healthy or asymptomatic status.

Conclusion

The implementation of regular screening intervals for tuberculin skin test (TST) and chest radiography, along with verbal screening, among pediatric household contacts under the age of 15 years seems to be beneficial for the National TB Elimination Programme (NTEP), despite the challenges faced during implementation. Innovative strategies should be explored by NTEP to ensure effective implementation.
Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria
Authors: Ige Fehintola Anthonia , Ohihoin Gregory Aigbe , Osuolale Kazeem , Dada Adedamola , Onyia Ngozi , Johnson Adeyemi , Okwuraiwe Azuka Patrick , Odediran Omoladun , Liboro Gideon , Aniedobe Maureen , Mogaji Sunday , Nwaiwu Stephanie Ogechi , Akande Ibukun Ruth , Audu Rosemary Ajuma , Salako Babatunde Lawal
Published: October 2023

Healthcare workers (HCWs) are disproportionately infected with SARS-CoV-2 when compared to members of the general public; estimating the seroprevalence of SARS-CoV-2 antibody and SARS-CoV-2 infection rate among HCWs is therefore crucial. This study was carried out in four health facilities in Lagos Nigeria to determine the prevalence of IgG antibodies (seroprevalence) and SARS-CoV-2 active infection rate via a positive rtPCR result, the cross-sectional study was conducted between December 2020 and July 2021. Nasopharyngeal and blood samples were collected from HCWs and screened for SARS-CoV-2 infection using the rtPCR technique and antibody using the Abbott anti-SARS-CoV-2 IgG CMIA assay, respectively. Demographic and occupational exposures data were obtained and analysed using descriptive and inferential statistics, variables significant via inferential statistics were subjected to a multivariate analysis. A total of 413 participants were enrolled, with a mean age in years of 38.4±11.0. The seroprevalence was 30.9% (115/372) while 63/395 (15.9%) were actively infected with the virus. HCWs whose job role had direct contact with patients had a higher percentage of SARS-CoV-2 infection when compared with those not in direct contact, also being a health care worker was significantly associated with getting a positive COVID-19 PCR result. In conclusion the SARS-CoV-2 seroprevalence seen in this study was higher than national serosurvey estimates indicating HCWs are at higher risk of COVID-19 infection when compared to the general public. Vaccination and effective implementation of infection control measures are important to protect HCWs.
Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells
Authors: Hillowe Andrew , Gordon Chris , Wang Liqun , Rizzo Robert C. , Trotman Lloyd C. , Ojima Iwao , Bialkowska Agnieszka , Kaczocha Martin
Published: October 2023

Prostate cancer is a leading cause of cancer-related deaths in men in the United States. Although treatable when detected early, prostate cancer commonly transitions to an aggressive castration-resistant metastatic state. While taxane chemotherapeutics such as docetaxel are mainstay treatment options for prostate cancer, taxane resistance often develops. Fatty acid binding protein 5 (FABP5) is an intracellular lipid chaperone that is upregulated in advanced prostate cancer and is implicated as a key driver of its progression. The recent demonstration that FABP5 inhibitors produce synergistic inhibition of tumor growth when combined with taxane chemotherapeutics highlights the possibility that FABP5 may regulate other features of taxane function, including resistance. Employing taxane-resistant DU145-TXR cells and a combination of cytotoxicity, apoptosis, and cell cycle assays, our findings demonstrate that FABP5 knockdown sensitizes the cells to docetaxel. In contrast, docetaxel potency was unaffected by FABP5 knockdown in taxane-sensitive DU145 cells. Taxane-resistance in DU145-TXR cells stems from upregulation of the P-glycoprotein ATP binding cassette subfamily B member 1 (ABCB1). Expression analyses and functional assays confirmed that FABP5 knockdown in DU145-TXR cells markedly reduced ABCB1 expression and activity, respectively. Our study demonstrates a potential new function for FABP5 in regulating taxane sensitivity and the expression of a major P-glycoprotein efflux pump in prostate cancer cells.
Greater number of weekly stairs climbed is associated with lower low back pain prevalence among female but not male physical therapists
Authors: Amabile Amy H. , Larson Sharon L. , Hoglund Lisa T. , Guarnieri John P. , McDonald Maureen , Reich Madeline R.
Published: October 2023

Introduction

Certain cardiovascular health benefits of stair climbing are now widely accepted, but no prior studies have as yet been found linking the quantity of stairs climbed to low back pain (LBP) morbidity. Low back pain is a common musculoskeletal impairment, and research has begun to show an association between LBP and gluteus maximus (GM) weakness. With stair climbing being the activity which most activates GM, the aim of the present research was to assess the relationship between stair ambulation and LBP prevalence. The hypothesis of this cross-sectional study was that individuals with LBP would report a significantly lower numbers of stair flights climbed compared with individuals without LBP.

Methods

A survey tool was developed and distributed via email to a convenience sample of orthopedic physical therapists. Survey items included information regarding medical history, physical activity, workplace, and LBP factors, using a one-year prevalence period.

Results

A total of 363 respondents took the survey and, after application of exclusion criteria, 248 records remained in our final sample. When analyzing all genders together, non LBP (NLBP) respondents reported a mean of 51.62 flights climbed per week; and LBP respondents reported 37.82 flights climbed per week, with P = 0.077. When males and females were analyzed separately, a statistically significant difference in mean number of flights of stairs climbed was found among female respondents (61.51 flights climbed for NLBP and 35.61 flights climbed for LBP females; P = 0.031). When analyzed based on chronicity of LBP, an even stronger association between stairs climbed and LBP prevalence was found for female respondents with acute LBP (P = 0.009).

Conclusions

More weekly stairs climbed was associated with a lower LBP prevalence among females, especially with respect to acute LBP. Randomized, longitudinal research is, however, required to confirm a relationship between stair climbing and LBP.
Signature of cardiac alterations in early and late chronic infections with Trypanosoma cruzi in mice
Authors: Arias-Argáez Bárbara Carolina , Dzul-Huchim Victor Manuel , Haro-Álvarez Ana Paulina , Rosado-Vallado Miguel Enrique , Villanueva-Lizama Liliana , Cruz-Chan Julio Vladimir , Dumonteil Eric
Published: October 2023

Chagas disease by Trypanosoma cruzi (T. cruzi) infection is a leading cause of myocarditis worldwide. Chagas cardiomyopathy is presented with a wide variety of conduction abnormalities including arrhythmias, first- and second-degree atrioventricular blockade, left ventricular systolic dysfunction and some cases heart failure leading to the death. Currently, there are no effective treatments available against advanced Chagas disease. With the advance in the development of novel therapies, it is important to utilize an animal model that can effectively replicate the diverse stages of Chagas disease, including chronic asymptomatic and symptomatic infection, that are akin to those observed in humans. Therefore, to characterize the cardiac alterations during the evolution of the infection, we evaluated the progression of cardiomyopathy caused by T. cruzi H1 infection in both BALB/c and ICR mouse models by performing electrocardiogram (ECG) studies in unanesthetized mice every month until 210 days post-infection (dpi). In the late chronic phase of infection, we also performed echocardiogram (ECHO) studies to further assess cardiac function. In conclusion, we demonstrated that ICR mice were more susceptible to cardiac alterations compared to BALB/c mice and both mouse strains are suitable experimental models to study chronic T. cruzi infection and novel treatments.
Heterogeneity of Alzheimer’s disease identified by neuropsychological test profiling
Authors: Nguyen Truc Tran Thanh , Lee Hsun-Hua , Huang Li-Kai , Hu Chaur-Jong , Yeh Chih-Yang , Yang Wei-Chung Vivian , Lin Ming-Chin
Published: October 2023

Alzheimer’s disease (AD) is a highly heterogeneous disorder. Untangling this variability could lead to personalized treatments and improve participant recruitment for clinical trials. We investigated the cognitive subgroups by using a data-driven clustering technique in an AD cohort. People with mild–moderate probable AD from Taiwan was included. Neuropsychological test results from the Cognitive Abilities Screening Instrument were clustered using nonnegative matrix factorization. We identified two clusters in 112 patients with predominant deficits in memory (62.5%) and non-memory (37.5%) cognitive domains, respectively. The memory group performed worse in short-term memory and orientation and better in attention than the non-memory group. At baseline, patients in the memory group had worse global cognitive status and dementia severity. Linear mixed effect model did not reveal difference in disease trajectory within 3 years of follow-up between the two clusters. Our results provide insights into the cognitive heterogeneity in probable AD in an Asian population.
Existing workloads among managers and healthcare workers during the COVID-19 pandemic: Meanings in the Amazon context
Authors: Monteiro Wagner Ferreira , Lima Kássia Janara Veras , Ferreira Darlisom Sousa , Andrade Lucas Lorran Costa de , Ramos Flávia Regina Souza
Published: October 2023

Introduction

The global COVID-19 pandemic has increased the concern and risks of health professionals exposed by acting on the front lines in combating and controlling the spread of the virus. This study aims at analyzing the workloads and their implications for the activities carried out by managers and health workers in the face of the COVID-19 pandemic in Manaus, Amazonas, Brazil.

Method

This is a qualitative study, of the case study type, that integrates a macro research that deals with the experiences built during the confrontation of the pandemic of COVID-19 in the capital of the state of Amazonas, Brazil, the epicenter of the pandemic in the country. Data production resorted to documentary analysis and semi-structured interviews with 56 managers or professionals from the Manaus Health Care Network. The analytical process was supported by the resources of the Atlas.ti 8.0 software and the precepts of Thematic Networks analysis.

Results

The thematic network “workloads” brought together three topics related to the experience of psychological, physiological and biological loads. Psychological workloads were strongly present in the work routine, being referred to in a more significant way. The sources that increase them are strongly related to work stress, dealing with suffering and death and excess demand on the service. Physiological loads were related to excessive working hours, staff shortages and activity overload. “Biological burdens” include exposure to the SARS-CoV-2 virus, constant contact with infected individuals, and individual protection as key elements of this set.

Conclusion

The study showed that both managers and workers have work processes and environments with conditions that tend to generate workloads that harm their health and safety, as well as institutions and patient care. Therefore, there is a need for more effective organizational actions in workers’ health surveillance, disease prevention, adequate working conditions, reducing workloads and promoting more resolute and less stressful work environments.
Maternal constipation is associated with allergic rhinitis in the offspring: A nationwide retrospective cohort study
Authors: Lee Ming-Hung , Wu Meng-Che , Wang Yu-Hsun , Wei James Cheng-Chung
Published: October 2023

Allergic rhinitis (AR) is a common atopic disease worldwide, and it was found that babies with constipation in their early life might have an increased risk of atopic diseases, including AR. Furthermore, recent studies also indicate that the maternal gut microbiota may influence babies. Thus, we extended the definition of early life in utero and evaluated the association between maternal constipation and the risk of AR in their babies. Using the Longitudinal Health Insurance Database, a subset of Taiwan’s National Health Insurance Research Database, we identified 102,820 constipated mothers and 102,820 matched controls between 2005 and 2015. Propensity score analysis was used to match birth year, child sex, birth weight, gestational age, mode of delivery, maternal comorbidities, and children antibiotics taken. Multiple Cox regression and subgroup analyzes were conducted to estimate the adjusted hazard ratio of childhood AR. The incidence of childhood AR was 83.47 per 1,000 person-years in constipated mothers. Adjusting children’s sex, birth weight, gestational age, mode of delivery, maternal comorbidities, and children antibiotic use, the results showed that the children whose mothers had constipation had a 1.20-fold risk of AR compared to children of mothers without constipation. Maternal constipation was associated with an increased risk of AR. Therefore, it is important to pay close attention to pregnant mothers with constipation.
intervención de los Areizábal en la iglesia de San Miguel de Alfaro (La Rioja) en el siglo XVI
Authors: Bermejo Malumbres Eloy
Published: October 2023

La exhumación de un documento conservado en el Archivo de la Real Chancillería de Valladolid ha arrojado nuevos datos sobre la historia constructiva de la iglesia de San Miguel de Alfaro. En este encontramos la presencia de algunos miembros de los Areizábal, una saga de maestros involucrados en la renovación del templo, cuyos resultados no cumplieron con lo esperado. El largo enfrentamiento judicial, sumado a las dificultades económicas y constructivas provocó una ralentización en el levantamiento del centro religioso.
decoración escultórica interior de la Capilla de Santa Catalina, antigua sala capitular de la Catedral de Burgos
Authors: Polanco Melero Carlos
Published: October 2023

La Capilla de Santa Catalina de la Catedral de Burgos se edificó como sala capitular en el segundo cuarto del siglo XIV. Su ambiciosa arquitectura, sobresaliente en el panorama castellano coetáneo, se completa con un rico programa escultórico, cuyo desarrollo en el interior del edificio es el objeto de estudio de este artículo. El interés historiográfico se ha centrado en el programa de las ocho grandes ménsulas que adornan la sala. A este respecto, se aportan algunas claves interpretativas basadas en el análisis visual de lo que se representa y su posible relación con conceptos generales presentes en el momento histórico y cultural en el que se esculpieron los relieves. La decoración escultórica exterior de la capilla será objeto de otro artículo.
La «caza del paco». La evolución del africanismo franquista a través de las ediciones de Diario de una Bandera
Authors: Iglesias Amorín Alfonso
Published: October 2023

Diario de una bandera, publicada en 1922, es la principal obra escrita por Francisco Franco, entonces comandante en el Protectorado español de Marruecos, y en ella relata las andanzas de la Primera Bandera de la Legión en 1921. La obra resulta interesante porque permite conocer diversos elementos del pensamiento del que luego sería dictador, en una fase anterior de su vida, y además una que marcó su carácter y su ideología.

            Además del análisis detallado de la mentalidad de Franco que se desprende del libro, en este artículo hemos realizado una comparación pormenorizada de las cinco ediciones que tuvo (1922, 1939, 1956, 1976 y 1986). Cotejar todas las versiones, página por página, nos ha permitido encontrar algunas interesantes diferencias entre ellas, que demuestran que el propio dictador no escapó de la censura de su régimen, y que cosas que había escrito en la versión original resultaban incómodas años después.
Cooperation in an Arrow-Karlin Type Supply Chain
Authors: Dobos Imre
Published: October 2023

In this paper we apply cooperative game theory concepts to analyze vertical supply chains. The bullwhip effect in a two-stage supply chain (supplier-manufacturer) in the framework of the Arrow-Karlin model with linear-convex cost functions is considered. It is assumed that both firms minimize their relevant costs, and two cases are examined: the supplier and the manufacturer minimize their relevant costs in a decentralized and in a centralized (cooperative) way. The question of how to share the savings of the decreased bullwhip effect in the centralized (cooperative) model is answered by transferable utility cooperative game theory tools.