bluuebunny/crossref_metadata_2025 huggingface dataset:
Broadband Polarization‐Sensitive Photodetection of Magnetic Semiconducting MnTe Nanoribbons
Authors: Ye Kun , Yan Junxin , Liu Lixuan , Li Penghui , Yu Zhipeng , Gao Yang , Yang Mengmeng , Huang He , Nie Anmin , Shu Yu , Xiang Jianyong , Wang Shouguo , Liu Zhongyuan
Published: April 2023

2D materials with low symmetry are explored in recent years because of their anisotropic advantage in polarization‐sensitive photodetection. Herein the controllably grown hexagonal magnetic semiconducting α‐MnTe nanoribbons are reported with a highly anisotropic (100) surface and their high sensitivity to polarization in a broadband photodetection, whereas the hexagonal structure is highly symmetric. The outstanding photoresponse of α‐MnTe nanoribbons occurs in a broadband range from ultraviolet (UV, 360 nm) to near infrared (NIR, 914 nm) with short response times of 46 ms (rise) and 37 ms (fall), excellent environmental stability, and repeatability. Furthermore, due to highly anisotropic (100) surface, the α‐MnTe nanoribbons as photodetector exhibit attractive sensitivity to polarization and high dichroic ratios of up to 2.8 under light illumination of UV‐to‐NIR wavelengths. These results demonstrate that 2D magnetic semiconducting α‐MnTe nanoribbons provide a promising platform to design the next‐generation polarization‐sensitive photodetectors in a broadband range.
Experimental study on the fatigue bond behavior of concrete beams reinforced with hybrid fiber‐reinforced polymer and steel bars
Authors: Xu Jiajing , Zhu Peng , Qu Wenjun
Published: April 2023

This paper presents an experimental program of the bond behavior of concrete beams reinforced with hybrid fiber‐reinforced polymer (FRP) and steel bars, and the bond behavior between flexural cracks is investigated. Under the static loading, both the slip of steel and glass FRP (GFRP) bars increased significantly after steel yielding, while the slip of steel bars presented a faster increase rate. A method of calculating the bond stress based on test data was proposed, and this method overcame the disadvantage of histogram distribution of the conventional method. An analytical model of calculating the bond stress was proposed, and was verified with the test results. Under the fatigue loading, the bond stress deteriorated more seriously with a higher upper limit of fatigue load. The slip increased rapidly at the initial stage, and remained approximately unchanged with the increase of fatigue cycles, and the slip increased dramatically when the beam was subjected to fatigue failure. After fatigue loading, the yielding strength and ultimate strength of steel bars showed an increase rate less than 5%, while the hardening phase decreased significantly. The ultimate tensile strength of GFRP bars after fatigue decreased in the range of 4.5%–32.3%, and the modulus for elasticity remained unchanged.
Stress–strain behavior and constitutive relation of rubberized plastic concrete under uniaxial and triaxial compression
Authors: Feng Ling‐Yun , Chen Ai‐Jiu , Liu Han‐Dong
Published: April 2023

Plastic concrete is a kind of flexible concrete cutoff wall material, which is used to solve the problem of poor coordinated deformation ability between ordinary concrete cutoff wall and surrounding soil. It has the characteristics of small elastic modulus and large limit strain, which greatly improves the operation condition of cutoff wall. In order to save bentonite resources and recycle waste automobile tires, this paper crushed waste automobile tires into rubber particles and mixed them into plastic concrete, through the uniaxial compression test and triaxial compression test, obtained the corresponding stress–strain curve, rubberized plastic concrete strength and deformation properties are studied and the rubber particles and the relationship between dosage. The test results show that the compressive strength of rubberized plastic concrete decreases with the increase of rubber particles content, but the deformation capacity increases with the increase of rubber particles content. In this paper, the regression analysis of rubberized plastic concrete constitutive relation and failure criterion including the influence factor of rubber particles are helpful to promote the engineering application of rubberized plastic concrete and reduce the exploitation of natural resources and environmental pollution.
Activating supply chain business models' value potentials through Systems Engineering
Authors: Nuerk Jochen , Dařena František
Published: April 2023

New business opportunities, driven by smart digitalization technology and initiatives such as Industry 4.0, significantly change business models and their innovation rate. The complexity of methodologies developed in recent decades for balancing exploration and exploitation activities of digital transformation has risen. Still, the desired integration levels across organizational levels were often not reached. Systems thinking promises to holistically consider interdisciplinary relationships and objectives of various stakeholders across supply chain ecosystems. Systems theory‐based concepts can simultaneously improve value identification and aligned transformation among supply networks’ organizational and technical domains. Hence, the study proposes synthesizing management science concepts such as strategic alignment with enterprise architecture concepts and artificial intelligence (AI)‐driven business process optimization to increase innovation productivity and master the increasing rate of business dynamics at the same time. Based on a critical review, the study explores concepts for innovation, transformation, and alignment in the context of Industry 4.0. The essence has been compiled into a systems engineering‐driven framework for agile value generation on operational processes and high‐order capability levels. The approach improves visibility for orchestrating sustainable value flows and transformation activities by considering the ambidexterity of exploring and exploiting activities and the viability of supply chain systems and sub‐systems. Finally, the study demonstrates the need to harmonize these concepts into a concise methodology and taxonomy for digital supply chain engineering.
Consistent truncations and dualities
Authors: Butter Daniel , Hassler Falk , Pope Christopher N. , Zhang Haoyu
Published: April 2023

Abstract

Recent progress in generalised geometry and extended field theories suggests a deep connection between consistent truncations and dualities, which is not immediately obvious. A prime example is generalised Scherk-Schwarz reductions in double field theory, which have been shown to be in one-to-one correspondence with Poisson-Lie T-duality. Here we demonstrate that this relation is only the tip of the iceberg. Currently, the most general known classes of T-dualities (excluding mirror symmetry) are based on dressing cosets. But as we discuss, they can be further extended to the even larger class of generalised cosets. We prove that the latter give rise to consistent truncations for which the ansatz can be constructed systematically. Hence, we pave the way for many new examples of T-dualities and consistent truncations. The arising structures result in covariant tensors with more than two derivatives and we argue how they might be key to understand generalised T-dualities and consistent truncations beyond the leading two derivative level.
Right-handed Dirac and Majorana neutrinos at Belle II
Authors: Han Tao , Liao Jiajun , Liu Hongkai , Marfatia Danny
Published: April 2023

Abstract

We assess the ability of the Belle II experiment to probe the Dirac or Majorana nature of a massive right-handed neutrino (RHN) N in the MeV to GeV mass range. We consider the production and decay of RHNs to proceed via new interactions described by the standard model effective field theory (SMEFT) extended with right-handed neutrino fields (SMNEFT), and not via mass mixing with active neutrinos. We find that Belle II has the potential to discover N if kinematically accessible. We perform detailed simulations of the angular distributions of lepton pairs from the decay of N produced in two-body and three-body decays of B mesons. We show that for mN above 100 MeV, Belle II can distinguish between Dirac and Majorana neutrinos at more than the 5σ CL for most operators, and the combination of the production and decay operators can be identified from the subsequent decay of the heavy neutrino. Also, the production operators can be identified using three-body B meson decay for any mN if the B → DℓN and B → D*ℓN events can be well separated.
Bilinear Optimal Control of the Keller–Segel Logistic Model in 2D-Domains
Authors: Braz e Silva P. , Guillén-González F. , Perusato C. F. , Rodríguez-Bellido M. A.
Published: April 2023

An optimal control problem associated to the Keller–Segel with logistic reaction system is studied in 2D domains. The control acts in a bilinear form only in the chemical equation. The existence of an optimal control and a necessary optimality system are deduced. The main novelty is that the control can be rather singular and the state (cell density u and the chemical concentration v) remains only in a weak setting, which is not usual in the literature.
Soil Suppressiveness Against Pythium ultimum and Rhizoctonia solani in Two Land Management Systems and Eleven Soil Health Treatments
Authors: Kurm Viola , Visser Johnny , Schilder Mirjam , Nijhuis Els , Postma Joeke , Korthals Gerard
Published: April 2023

The soil microbiome is known to be crucial for the control of soil-borne plant diseases. However, there is still little knowledge on how to modify the soil microbiome to induce or increase disease suppressiveness. In the present study, we applied eleven soil health treatments combined with conventional and organic agricultural management in a long-term field experiment. Suppressiveness against Pythium ultimum and Rhizoctonia solani was assessed in bioassays for 2 years. In addition, the microbiome community composition and microbial abundance were determined. We found that while several treatments changed the microbial community composition compared to the control, only a combination treatment of anaerobic soil disinfestation, hair meal, and compost addition resulted in suppressiveness against P. ultimum. Pythium suppressiveness is likely to have been caused by an increased microbial abundance and activity. Moreover, the increased abundance of several bacterial taxa, such as Pseudomonas sp., Chryseobacterium sp., members of the family Chitinophagaceae, and the fungal genus Mortierella sp. and family Trichosporonaceae, was measured. There was no overall difference in suppressiveness between conventional and organic land management. Also, no suppressiveness against R. solani could be detected. Our results indicate that a treatment combining the reduction of microorganisms followed by a recovery phase with high amounts of organic amendments may be more effective in inducing suppressiveness than treatments consisting of only one of these measures.
Periprosthetic patella fractures in total knee replacement and revision surgeries: how to diagnose and treat this rare but potentially devastating complication—a review of the current literature
Authors: Masoni Virginia , Giustra Fortunato , Bosco Francesco , Lo Carmine Lorenzo , Capella Marcello , Cacciola Giorgio , Risitano Salvatore , Sabatini Luigi , Massè Alessandro
Published: April 2023

Purpose

Periprosthetic patella fractures (PPPFs) are infrequent but potentially devastating complications after total knee arthroplasty (TKA) and revision TKA (rTKA). These fractures may occur both in resurfaced and un-resurfaced patella. This review summarizes the current literature on PPPFs to help orthopedic surgeons diagnose and treat this uncommon but extremely challenging TKA complication.

Methods

A comprehensive search was performed in three databases: PubMed, SCOPUS, and EMBASE. All relevant information was retrieved and summarized in this narrative review.

Results

In the studies analyzed, there is a general trend in favor of nonsurgical treatment, except for implant loosening or extensor lag with extensor apparatus disruption, because surgery is often associated with poor clinical outcomes and high complication rates.

Conclusion

PPPF is a rare but catastrophic event in TKA and rTKA, occurring mainly in a reconstructed patella. Patient-, implant-, and surgical technique-related factors contribute to its multifactorial etiopathogenesis. Prevention plays a crucial role in reducing the PPPFs rate. Conservative management is the treatment of choice due to high surgery complication rates unless implant loosening, or extensor apparatus disruption occurs.
Reversible cerebral vasoconstriction syndrome: strategies to early diagnosis and the role of transcranial color-coded doppler ultrasonography (TCCD)
Authors: Merli Nicola , Padroni Marina , Azzini Cristiano , Bernardoni Andrea , Marcialis Carla , Tugnoli Valeria , Inchingolo Vincenzo , Pugliatti Maura
Published: April 2023

Background

Reversible
cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular transitory condition characterized by severe headache, possible concomitant acute neurological symptoms, evidence of diffuse multifocal segmental constriction of cerebral arteries, and usually spontaneously resolving within 3 months. Putative causes and/or precipitating factors are vasoactive drugs—e.g., antidepressants, α-sympathomimetics, triptans—post-partum, and immunosuppressants.

Case presentation

We report the case of a middle-aged woman referred to the emergency room (ER) with a 7-day long intense headache and vomit. Cerebral non-contrast computed tomography (CT) was negative for acute ischemic lesions or intracranial bleedings. She was again referred to ER 7 days later with additional fluctuating episodes of weakness in left arm and both lower limbs. A new brain CT was negative. Due to worsening headache, a transcranial color-coded Doppler (TCCD) was performed, which showed diffuse multifocal blood flow acceleration in all principal intracranial vessels, and particularly on the right hemisphere. These findings were subsequently confirmed at MR angiogram and digital subtraction angiography.

Conclusion

TCCD imaging is a non-invasive and relatively inexpensive tool which provides real-time information on cerebrovascular function, blood flow velocities, and hemodynamic changes. TCCD may be a powerful tool in the early detection of acute infrequent cerebrovascular conditions, as well as in monitoring their course and the therapeutic response.
Simulation-based evaluation of SAR and flip angle homogeneity for five transmit head arrays at 14 T
Authors: Harrevelt Seb D. , Roos Thomas H. M. , Klomp Dennis W. J. , Steensma Bart R. , Raaijmakers Alexander J. E.
Published: April 2023

Introduction

Various research sites are pursuing 14 T MRI systems. However, both local SAR and RF transmit field inhomogeneity will increase. The aim of this simulation study is to investigate the trade-offs between peak local SAR and flip angle uniformity for five transmit coil array designs at 14 T in comparison to 7 T.

Methods

Investigated coil array designs are: 8 dipole antennas (8D), 16 dipole antennas (16D), 8 loop coils (8D), 16 loop coils (16L), 8 dipoles/8 loop coils (8D8L) and for reference 8 dipoles at 7 T. Both RF shimming and kT-points were investigated by plotting L-curves of peak SAR levels vs flip angle homogeneity.

Results

For RF shimming, the 16L array performs best. For kT-points, superior flip angle homogeneity is achieved at the expense of more power deposition, and the dipole arrays outperform the loop coil arrays.

Discussion and conclusion

For most arrays and regular imaging, the constraint on head SAR is reached before constraints on peak local SAR are violated. Furthermore, the different drive vectors in kT-points alleviate strong peaks in local SAR. Flip angle inhomogeneity can be alleviated by kT-points at the expense of larger power deposition. For kT-points, the dipole arrays seem to outperform loop coil arrays.
MLKL and other necroptosis-related genes promote the tumor immune cell infiltration, guiding for the administration of immunotherapy in bladder urothelial carcinoma
Authors: Zhong Boqiang , Wang Youzhi , Liao Yihao , Liang Jiaming , Wang Keke , Zhou Diansheng , Zhao Yang , Jiang Ning
Published: April 2023

The involvement of necroptosis in the immunosuppressive tumor microenvironment has been established and has been shown to contribute to the growth of pancreatic ductal adenocarcinoma, indicating its role in promoting tumor development. However, the relationship between necroptosis and bladder urothelial carcinoma (BUC) has yet to be fully understood. To shed light on this issue, our study aimed to uncover the impact of necroptosis on immune cell infiltration and immunotherapy response in BUC patients. We conducted an analysis of 67 necroptosis genes to assess their expression and genomic changes across pan-cancer and identified 12 necroptosis genes that are prognostically relevant and associated with immune subtypes and tumor stemness in BUC. Using a public database of 1841 BUC samples, we then performed Unsupervised Cluster Analysis and discovered two distinct necroptotic phenotypes in BUC. These phenotypes showed significant differences in molecular subtypes, immune infiltration patterns, and gene mutation profiles. We confirmed this discovery in BUC through qPCR and WB experiments. To evaluate the impact of necroptosis on prognosis, chemotherapy sensitivity, and immunotherapy response (such as anti-PD-L1), we developed a principal component analysis model called NecroScore. Finally, we validated the effects of RIPK3 and MLKL through a nude mouse transplantation model for BUC. Our study has uncovered that necroptosis plays a role in shaping the tumor immune microenvironment in BUC. The high necroptosis phenotype (Cluster B) was characterized by a higher abundance of tumor immunosuppressive cells and more key biological processes driving tumor progression, while the low necroptosis group (Cluster A) had higher FGFR3 mutations. We found that the infiltration levels of immune cells, including CD8+ T cells, were significantly different between FGFR3 mutated and wild-type (WT) samples. Our results confirmed the reliability of NecroScore as a comprehensive assessment tool for evaluating the immunotherapeutic effect and prognosis of BUC patients, with high NecroScore values favoring basal-like differentiation and lower FGFR3 alterations. We also observed that high expression of MLKL had a significant inhibitory effect on tumor growth and increased neutrophil infiltration in vivo. In our study, we uncovered the regulation pattern of necroptosis in the tumor immune microenvironment of BUC. Additionally, we developed a scoring tool called NecroScore that can be utilized to predict the most suitable chemotherapy and immunotherapy strategy for bladder urothelial carcinoma patients. This tool can effectively guide the chemotherapy and immunotherapy regimens for patients with advanced BUC.
Electrospun HPMC/PEO-blend orodispersible films: how slight batch differences affect the crucial mechanical properties
Authors: Asatiani Nikifor , Filipová Barbora , Pechočiaková Miroslava , Kluk Anna , Kunc Štepán , Mikeš Petr
Published: April 2023

Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g., the dissolution rate and the ease of administration. This study involved the use of two types of hydroxypropyl methylcelluloses of low molecular weight obtained from three different manufacturers as the matrix. The SEM, FTIR, RAMAN, and DSC analyses revealed comparable values for all the fabricated materials. However, the mechanical properties of the fibers differed significantly, with electrospun Methocel E5/PEO proving to be particularly brittle. This is probably caused by the different arrangements of substituted methoxy- and hydroxypropyl groups of studied HPMCs. It is hoped that this paper will serve as an example of the extent to which slight differences between HPMC powder batches can dramatically alter the key properties of electrospun orodispersible films.
Learner autonomy, learner engagement and learner satisfaction in text-based and multimodal computer mediated writing environments
Authors: Mohammadi Zenouzagh Zohre , Admiraal Wilfried , Saab Nadira
Published: April 2023

Technology creates variant learning experiences which are context specific. This study examined the comparative potential of multimodal and text-based Computer Mediated Communication (CMC) in fostering learner autonomy, learner engagement and learner e-satisfaction as well as learner writing quality. To this end, 40 Iranian male and female EFL (English as foreign language) students were selected on the basis of their writing proficiency and were randomly assigned into text-based and multimodal CMC research groups. Learner autonomy was investigated using Van Nguyen and Habók ‘s learner autonomy questionnaire, which had 40 items rated on 5 point likert scale, both before and after the treatment. Student engagement was tracked by analyzing transcription of stored conversations of Moodle and Discussion logs of an online writing forum, using a coding scheme to identify cognitive, emotional, and behavioral student engagement. The potential of text-based CMC and Multimodal CMC in fostering writing quality was examined by comparing students’ writing before and after treatment. Finally, students were asked to write reflective essays on their evaluation of efficacy of the learning environments. Content analysis was conducted on the open and axial coding of indicators of student satisfaction. The results of between group comparison indicated that students were more autonomous in text-based modality than in multimodal CMC. Chi-square analysis indicated that text-based CMC group outperformed multimodal CMC group in terms of behavioral and cognitive engagement. Yet, multimodal CMC group reported higher emotional and social engagement. One-way ANCOVA results also indicated that the students in text-based CMC group outperformed Multimodal CMC group in terms of writing quality. Learner e-satisfaction was examined by network mapping of open codes of student reflective essays. The study identified four categories that reflected students’ e-satisfaction: learner dimension (including learners’ attitude, learner internet self-efficacy), teacher dimension (including teacher presence, teacher digital competences), curriculum dimension (including curriculum flexibility, course quality, flexibility in interaction support system) and internet dimension (including internet quality and support system). However, internet dimension received negative judgments from both groups. The implications of the study and suggestions for further research are discussed.
Blue Food Sovereignty Benefits Social-Ecological Resilience: A Case Study of Small-Scale Fisheries Co-Management and Mariculture in Samoa
Authors: Quimby Barbara , Roque Anaís Delilah , Nébié Elisabeth Kago Ilboudo , Levine Arielle , Amaama Safua Akeli , Wutich Amber , Brewis Alexandra , Samuelu Lemasaniai Erenei
Published: April 2023

“Blue” (aquatic) food systems have a vital role in providing nutrition, livelihoods, and food security for coastal communities, but addressing and evaluating issues of equity and social resilience continue to challenge small-scale fisheries management. We examine how marine aquaculture and co-management approaches that integrate traditional institutions can support food sovereignty for more equitable blue food systems. Interviews with stakeholders in 11 fishing communities in Samoa indicate that several benefits associated with food sovereignty are derived from co-managed village fish reserves. Reserves support biodiversity health and are a source of culturally valued seafoods that build food security, social capital, and sustainable livelihood opportunities for women. Local values, food systems, providers, and consumers are centered, though traditional hierarchies present challenges for equitable decision-making. Our findings demonstrate how incorporating food sovereignty into the operation and evaluation of fisheries co-management can aid in addressing equity and resilience.
Perceived Nexus Between Non-Invigilated Summative Assessment and Mental Health Difficulties: A Cross Sectional Studies
Authors: Graf Amanda , Adama Esther , Afrifa-Yamoah Ebenezer , Adusei-Asante Kwadwo
Published: April 2023

The COVID-19 pandemic rapidly led to changes in the mode of teaching, learning and assessments in most tertiary institutions worldwide. Notably, non-invigilated summative assessments became predominant. These changes heightened anxiety and depression, especially among individuals with less resilient coping mechanism. We explored the perceptions and experiences of mental health difficulties of students in tertiary education regarding non-invigilated alternative assessments in comparison to invigilated assessments. A pragmatic, mixed method cross sectional design was conducted online via Qualtrics. Thematic analysis of text was carried out using NVivo 12. In the quantitative analysis, univariable and multivariable ordinal logistic models were used to examine the potential factors for preference among students in higher education. A total of 380 Nursing and Social Science students responded to the survey. Approximately 77% of students perceived non-invigilated assessments to be less stressful compared to invigilated exams. Age, course of study, stage of studies, and number of units enrolled per semester were identified as significant drivers for students’ perceived preference for non-invigilated assessments. There was an inverse relationship between the perception of stress associated with invigilated exams and the age of students. For instance, students aged between 18-24 were 5 times more likely to prefer non-invigilated exams compared to those aged 55 or more. Comparatively, students in early stages of studies had higher preference for non-invigilated assessments. However, there was a preference reversal for students enrolled in 2 or less units per semester. Social sciences students were two times more likely to prefer non-invigilated examinations to invigilated examinations compared to nursing students. The findings reinforce the use of alternative assessments in higher education as a mitigating agency to lessen the mental health burden of tertiary students in post COVID-19 era.
Collective renovation decisions in multi-owned housing management: the case of public–private homeowners associations in Poland
Authors: Muczyński Andrzej
Published: April 2023

The increasing popularity of multi-owned housing in various parts of the world and the need to constantly maintain these stocks in good condition raises issues of collective renovation decisions made by groups of unit owners in this housing sector. The main aim of the study was to identify the exogenous factors influencing collective decision-making actions of public–private homeowners associations regarding common property renovations in the management of housing condominiums in Poland. To achieve this aim, an original multi-stage top-down research methodology was applied. As the dependent variable representing the success of collective decision-making actions on common property renovations, the renovation fund rate passed by homeowners associations was adopted. Empirical research was conducted on representative samples of public–private homeowners associations with the participation of the municipality of Olsztyn in Poland. The results showed that building age, the number of unit owners and the share of the municipality in the common property significantly influenced renovation fund rates,ceteris paribus, with the influence of the former factor being positive and the others negative. This confirmed the hypothesis that the municipalities tend to negatively influence the collective renovation decisions of public–private homeowners associations by their shares in common properties. This study contributes to collective action theory when public and private actors co-participate in group decision-making and has far-reaching policy and practical implications. Hence, further research on this topic in different markets and institutional arrangements is recommended.
Cost-effectiveness of federal CDBG-DR Road Home Program mitigation assistance in Jefferson Parish, Louisiana
Authors: Al Assi Ayat , Mostafiz Rubayet Bin , Friedland Carol J. , Rohli Robert V. , Taghinezhad Arash , Rahim Md Adilur
Published: April 2023

After Hurricanes Katrina and Rita in 2005, the State of Louisiana received federal Community Development Block Grant Disaster Recovery (CDBG-DR) assistance, administered by the Louisiana Office of Community Development (OCD) as the Road Home Program, to provide homeowners with the required matching funds for elevating damaged homes under the Federal Emergency Management Agency (FEMA) Hazard Mitigation Grant Program (HMGP). This research evaluates the cost-effectiveness of the Road Home Program elevation mitigation assistance for a case study of homes in Jefferson Parish, Louisiana, using benefit–cost analysis (BCA) based on average annual loss (AAL) prediction. We use multiple return period flood depths from FEMA RiskMAP non-regulatory flood depth and calculate flood risk reduction as the difference between pre- and post-elevation AAL. We compute benefit–cost ratio (BCR) and net benefit–cost ratio (NBCR) of the elevation mitigation investment across multiple time horizons, considering several funding scenarios. Then, we determine optimal first-floor height (FFH) by foundation type and 100-year flood depth. The analysis reveals that elevating existing homes by either 3 feet above the ground or to the base flood elevation (BFE; 100-year flood elevation), whichever is higher, reduces the median AAL by 98%. This elevation generates a BCR of 1.5 and 1.7 over a 30-year mortgage and a 70-year building lifetime, respectively, if the benefit is allocated proportionately. These results enhance understanding of cost-effectiveness of federal elevation mitigation investments, benefits of elevating homes above the minimum requirements, and most effective elevated heights for homes.
Physical and mental health of breast cancer patients and survivors before and during successive SARS-CoV-2-infection waves
Authors: Bargon Claudia A. , Mink van der Molen Dieuwke R. , Batenburg Marilot C. T. , van Stam Lilianne E. , van Dam Iris E. , Baas Inge O. , Veenendaal Liesbeth M. , Maarse Wiesje , Sier Maartje , Schoenmaeckers Ernst J. P. , Burgmans Josephina P. J. , Bijlsma Rhodé M. , van der Leij Femke , Doeksen Annemiek , Young-Afat Danny A. , Verkooijen Helena M.
Published: April 2023

Purpose

During the first SARS-CoV-2-infection wave, a deterioration in emotional well-being and increased need for mental health care were observed among patients treated or being treated for breast cancer. In this follow-up study, we assessed patient-reported quality of life (QoL), physical functioning, and psychosocial well-being during the second SARS-CoV-2-infection wave in a large, representative cohort.

Methods

This longitudinal cohort study was conducted within the prospective, multicenter UMBRELLA breast cancer cohort. To assess patient-reported QoL, physical functioning and psychosocial well-being, COVID-19-specific surveys were completed by patients during the first and second SARS-CoV-2-infection waves (April and November 2020, respectively). An identical survey was completed by a comparable reference population during the second SARS-CoV-2-infection waves. All surveys included the validated EORTC-QLQ-C30/BR23, HADS and “De Jong-Gierveld Loneliness” questionnaires. Pre-COVID-19 EORTC-QLQ-C30/BR23 and HADS outcomes were available from UMBRELLA. Response rates were 69.3% (n = 1106/1595) during the first SARS-CoV-2-infection wave and 50.9% (n = 822/1614) during the second wave. A total of 696 patients responded during both SARS-CoV-2-infection waves and were included in the analysis comparing patient-reported outcomes (PROs) during the second SARS-CoV-2-infection wave to PROs during the first wave. Moreover, PROs reported by all patients during the second SARS-CoV-2-infection wave (n = 822) were compared to PROs of a similar non-cancer reference population (n = 241) and to their pre-COVID-19 PROs.

Results

Patient-reported QoL, physical functioning, and psychosocial well-being of patients treated or being treated for breast cancer remained stable or improved from the first to the second SARS-CoV-2-infection wave. The proportion of emotional loneliness reduced from 37.6 to 29.9% of patients. Compared to a similar non-cancer reference population, physical, emotional, and cognitive functioning, future perspectives and symptoms of dyspnea and insomnia were worse in patients treated or being treated for breast cancer during the second SARS-CoV-2-infection wave. PROs in the second wave were similar to pre-COVID-19 PROs.

Conclusion

Although patients scored overall worse than individuals without breast cancer, QoL, physical functioning, and psychosocial well-being did not deteriorate between the first and second wave. During the second wave, PROs were similar to pre-COVID-19 values. Overall, current findings are cautiously reassuring for future mental health of patients treated or being treated for breast cancer.
Psychometric properties of the Reintegration to Normal Living Index for sepsis survivors
Authors: Streich Kathleen , Hartog Christiane S. , Fleischmann-Struzek Carolin , Rose Norman , Bichmann Anna , Kesselmeier Miriam , Schiefenhövel Fridtjof , Schmieding Malte , Born Sebastian
Published: April 2023

Purpose

Return to a normal state of living is a key patient-relevant outcome for sepsis survivors. The Reintegration to Normal Living Index (RNLI) assesses self-perceived participation in patients with chronic disease, but its psychometric properties have been analyzed neither for patients after sepsis nor in a German patient cohort. This study aims to analyze the psychometric properties of the German version of the RNLI in sepsis survivors.

Methods

In a prospective multicenter survey study, 287 sepsis survivors were interviewed 6 and 12 months after hospital discharge. Multiple-group categorical confirmatory factor analyses with three competing models were used to explore the factor structure of the RNLI. Concurrent validity was evaluated in relation to the EQ-5D-3L and the Barthel Index of Activities of Daily Living (ADL).

Results

Regarding structural validity, all models showed an acceptable model fit. Because of high correlation between the latent variables in the two-factor models (up to r = 0.969) and for reason of parsimony, we opted for the common factor model to analyze the concurrent validity. Our analyses showed moderate positive correlations between RNLI score and ADL score (r ≥ 0.630), EQ-5D-3L visual analogue scale (r ≥ 0.656) and EQ-5D-3L utility score (r ≥ 0.548). The reliability assessed by McDonald’s Omega was 0.94.

Conclusion

We found convincing evidence for good reliability, structural and concurrent validity of the RNLI in German sepsis survivors. We propose to use the RNLI in addition to generic health-related quality of life measures to assess the reintegration to normal living after sepsis.
Does the bank-firm human relationship still matter for SMEs? The game-changing role of digitalization
Authors: Fasano Francesco , La Rocca Tiziana
Published: April 2023

Noteworthy contributions have highlighted that human contact is a considerable factor in bank-firm relationships. It allows the acquisition of soft information, which alleviates information asymmetries and increases the use of bank debt. The advent of digital technologies in the information collection process open new horizons and change the role of personal contacts in bank-firm interactions, as entrepreneurs visit bank branches less frequently. This study uses a large sample of Italian SMEs from 2011 to 2020 and finds that the rapid increase and use of digital instruments have reduced the positive influence of physical closeness between banks and SMEs on the indebtedness levels. Interestingly, our study has also found that the COVID-19 crisis did not amplify this moderating effect. Results support theories that human contact is an important factor in bank-firm relationships because it allows the acquisition of soft information, which alleviates information asymmetries and increases the use of bank debt. Our study suggests that close human ties are still extremely relevant and digitalization should be exploited to support the collection of the kind of qualitative soft information that is crucial in debt negotiations.
Kinkeeping Across Families: The Central Role of Mothers and Stepmothers in the Facilitation of Adult Intergenerational Ties
Authors: Hornstra Maaike , Ivanova Katya
Published: April 2023

A kinkeeper is the person within the household that is involved in the management of family relationships, a position traditionally fulfilled by women. Due to the increased complexity of family life, which resulted from the rise in divorce and remarriage, the kinkeeper role might nowadays be particularly important but also more ambiguous. First, we examined differences in parental involvement in kinkeeping (buying presents, organizing outings, relaying family news, and discussing problems) along the lines of gender, family structure, and biological relatedness. Second, we explored whether the kinkeeping of parents and their partners is effective in the facilitation of intergenerational closeness with adult children. We used the OKiN survey, which includes information on kinkeeping in N = 746 intact, N = 982 mother-stepfather, and N = 1,010 father-stepmother families. Findings indicated a central facilitative role for mothers and stepmothers. Substantial gaps were found between mothers and fathers, married and divorced parents, and biological and stepparents with respect to the (variety of) kinkeeping in which these parents were involved. Yet, the contrasts of biological relatedness and family structure were also found to be gendered, as these gaps were smaller for mothers than fathers. Finally, an association was found between adult closeness with biological parents and the kinkeeping of the spouse, regardless of the nature of the relationship between the spouse and adult child. This implies that a stepmother can be just as effective as a married biological mother in facilitating the ties between a father and his biological children.
A Statistical Finite Element Method Integrating a Plurigaussian Random Field Generator for Multi-scale Modelling of Solute Transport in Concrete
Authors: Ricketts Evan John , Freeman Brubeck Lee , Cleall Peter John , Jefferson Anthony , Kerfriden Pierre
Published: April 2023

A new model for the multi-scale simulation of solute transport in concrete is presented. The model employs plurigaussian simulations to generate stochastic representations of concrete micro- and meso-structures. These are idealised as two-phase medium comprising mortar matrix and pores for the micro-structure, and mortar and large aggregate particles for the meso-structure. The generated micro- and meso-structures are employed in a finite element analysis for the simulation of steady-state diffusion of solutes. The results of the simulations are used to calculate effective diffusion coefficients of the two-phase micro- and meso-structures, and in turn, the effective diffusion coefficient at the macro-scale at which the concrete material is considered homogenous. Multiple micro- and meso-structures are generated to account for uncertainty at the macro-scale. In addition, the level of uncertainty in the calculated effective diffusion coefficients is quantified through a statistical analysis. The numerical predictions are validated against experimental observations concerning the diffusion of chloride through a concrete specimen, suggesting that the generated structures are representative of the pore-space and coarse aggregate seen at the micro- and meso-scales, respectively. The method also has a clear advantage over many other structural generation methods, such as packing algorithms, due to its low computational expense. The stochastic generation method has the ability to represent many complex phenomena in particulate materials, the characteristics of which may be controlled through the careful choice of intrinsic field parameters and lithotype rules.
Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers
Authors: Song Guodong , Wang Li , Tang Junlong , Li Haohui , Pang Shuyu , Li Yan , Liu Li , Hu Junyuan
Published: April 2023

Background and aims

Two of the most lethal gastrointestinal (GI) cancers, gastric cancer (GC) and colon cancer (CC), are ranked in the top five cancers that cause deaths worldwide. Most GI cancer deaths can be reduced by earlier detection and more appropriate medical treatment. Unlike the current “gold standard” techniques, non-invasive and highly sensitive screening tests are required for GI cancer diagnosis. Here, we explored the potential of metabolomics for GI cancer detection and the classification of tissue-of-origin, and even the prognosis management.

Methods

Plasma samples from 37 gastric cancer (GC), 17 colon cancer (CC), and 27 non-cancer (NC) patients were prepared for metabolomics and lipidomics analysis by three MS-based platforms. Univariate, multivariate, and clustering analyses were used for selecting significant metabolic features. ROC curve analysis was based on a series of different binary classifications as well as the true-positive rate (sensitivity) and the false-positive rate (1-specificity).

Results

GI cancers exhibited obvious metabolic perturbation compared with benign diseases. The differentiated metabolites of gastric cancer (GC) and colon cancer (CC) were targeted to same pathways but with different degrees of cellular metabolism reprogramming. The cancer-specific metabolites distinguished the malignant and benign, and classified the cancer types. We also applied this test to before- and after-surgery samples, wherein surgical resection significantly altered the blood-metabolic patterns. There were 15 metabolites significantly altered in GC and CC patients who underwent surgical treatment, and partly returned to normal conditions.

Conclusion

Blood-based metabolomics analysis is an efficient strategy for GI cancer screening, especially for malignant and benign diagnoses. The cancer-specific metabolic patterns process the potential for classifying tissue-of-origin in multi-cancer screening. Besides, the circulating metabolites for prognosis management of GI cancer is a promising area of research.
Assessing the risks of capecitabine and its active metabolite 5-fluorouracil to freshwater biota
Authors: Venâncio Cátia , Monteiro Bruna , Lopes Isabel , Sousa Ana C. A.
Published: April 2023

Capecitabine (CAP, prodrug) and 5-fluorouracil (5-FU, its active metabolite) are two of the most prominent cytostatics, for which no clear picture can be drawn regarding potential concentrations of effect for freshwater biota, with CAP being grouped in the least studied cytostatic, whereas 5-FU has been classified as of no and of high environmental risk. Accordingly, the present work aimed to assess the ecotoxicity of CAP and 5-FU in three freshwater species, which included a 72-h assay with the producerRaphidocelis subcapitata; a 96-h assay with the invertebrate secondary consumerHydra viridissima; and a 96-h assay with embryos of the vertebrate secondary consumerDanio rerio. The following endpoints were monitored: yield and population growth rate for the algae; mortality, morphological alterations, and post-exposure feeding rates for the cnidarian; and mortality, hatching, and malformations for the fish. Overall, organisms’ sensitivity to CAP decreased in the following order:R. subcapitata > H. viridissima > D. rerio, whereas for 5-FU, it decreased in the following order:H. viridissima > D. rerio > R. subcapitata. For CAP, no median lethal effective concentrations (LC/EC50) were possible to compute forD. rerio, with no significant mortality or malformations registered in embryos exposed at concentrations up to 800 mg L−1. ForR. subcapitata, the EC50s were 0.077 and 0.63 mg L−1for yield and growth rate, respectively, and forH. viridissima, the EC50,30 minfor feeding was 22.0 mg L−1. For 5-FU, no EC50scould be computed forR. subcapitata, whilst the EC50sforH. viridissimamortality and feeding were 55.4 and 67.9 mg L−1, respectively, and forD. rerio, the LC50,96 hand EC50,96 h(hatching and abnormalities) were 4546, 4100, and 2459 mg L−1, respectively. Assuming similar modes of action for both compounds and their co-occurrence, the combined risk quotient of the two chemicals was determined to be 7.97, which represents a risk for freshwater biota. Anticipating the increased consumption of these compounds and cancer development trends worldwide, these impacts may be further aggravated.
Selenium nanoparticles induce growth and physiological tolerance of wastewater‑stressed carrot plants
Authors: El-Batal Ahmed I. , Ismail Mohamed A. , Amin Mohamed A. , El-Sayyad Gharieb S. , Osman Mahmoud S.
Published: April 2023

Climate changes have a direct impact on agricultural lands through their impact on the rate of water levels in the oceans and seas, which leads to a decrease in the amount of water used in agriculture, and therefore the use of alternative sources of irrigation such as wastewater and overcoming its harmful effect on plants was one of the solutions to face this problem. In the present study, the impacts of the synthesized selenium nanoparticles (Se NPs) alone or in combination with glycine betaine and proline treatments on the growth, physiological, and yield attributes of wastewater irrigated carrot plants are investigated. Furthermore, to evaluate heavy metals uptake and accumulation in edible plant parts. The usage of wastewater to carrot plants significantly increased free proline contents, total phenols, superoxide dismutase, catalase, peroxidase, polyphenol oxidase, Malondialdehyde (MDA), and hydrogen peroxide (H2O2) throughout the two growth stages. While total soluble carbohydrate and soluble protein content in carrot shoots and roots were significantly reduced. Moreover, the concentrations of nickel (Ni), cadmium (Cd), lead (Pb), and cobalt (Co) in carrot plants were considerably higher than the recommended limits set by international organizations. Application of selenium nanoparticles alone or in combination with glycine betaine and proline reduced the contents of Ni, Cd, Pb, and Co; free proline; total phenols; superoxide dismutase; catalase; peroxidase; polyphenol oxidase; Malondialdehyde (MDA) and Hydrogen peroxide (H2O2) in carrot plants. However, morphological aspects, photosynthetic pigments, soluble carbohydrates, soluble protein, total phenol, and β-Carotene were enhanced in response to Se NPs application. As an outcome, this research revealed that Se NPs combined with glycine betaine and proline can be used as a strategy to minimize heavy metal stress caused by wastewater irrigation in carrot plants, consequently enhancing crop productivity and growth.