bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMIZING THE DEVELOPMENT OF ISLAMIC FINANCIAL INSTITUTIONS IN WEST SUMATRA: ROLE OF LOCAL WISDOM ANALYSIS OF TUNGKU TIGO SAJARANGAN
Authors: Mursal Mursal , Cahya Bayu Tri
Published: June 2019

This study aims to analyze how the convergence of Tungku Tigo Sajarangan in sharia economic development through Islamic Financial Institutions (IFI), and then constructs how the concept of sharia economic development is based on the local wisdom of Tungku Tigo Sajarangan in developing IFI.

This research is a qualitative research with a sociological approach. The source of this research data was obtained from the informants who were considered to have information about the focus of this study, namely IFI managers and other informants who were considered to support this research.

Listening to the data obtained, this study concludes: First, the Tungku Tigo Sajarangan has not given an optimal role in the development of IFI in West Sumatra. Second, optimizing the role of Tungku Tigo Sajarangan in the development of IFI can be strengthened by increasing the synergy with TTS internal and related parties to perform socialization of sharia economic norms in massive, identification of syar'i transaction products, and internalization of adat basandi syarak, syarak basandi kitabullah.

 
METODE DONGENG DAN PEMBENTUKAN JIWA RELIGIUS ANAK PENYANDANG TUNA GRAHITA RINGAN
Authors: Isnawati Zakiyah
Published: June 2019

Kemajuan teknologi, pengetahuan dan pergerakan zaman menuntut kita untuk terus melakukan inovasi pembelajaran. Perbedaan generasi mempengaruhi perbedaan model, pendekatan dan metode pembelajaran serta gaya belajar siswa. Sebagai seorang guru, kita harus menyesuaikan gaya belajar siswa sehingga pembelajaran bisa berhasil mencapai tujuan.  Jika kita tidak melakukan penyesuaian, maka pembelajaran tidak akan berhasil dan  pendidikan akan tertinggal jauh dari perkembangan zaman
Control of Electrical and Optical Parameters of Humidity Sensors Active Elements Based on Tin Oxides Films with Variable Composition
Authors: Adamchuck D. V. , Ksenevich V. K.
Published: June 2019

The aim of this work is development of technique for synthesis of tin oxides films with various stoichiometric composition, characterized by high electrical conductivity and light transmittance in the UV and visible range of the electromagnetic spectrum, for their further application as humidity and gas sensors, as well as electrodes for electro-and photocatalytic converters.

Nonstoichiometric SnO/SnO2 /SnO2−δ films were synthesized by reactive magnetron sputtering of tin onto glass substrates in argon plasma with oxygen addition and with subsequent thermal oxidation of the formed layers in air. To change the structural, optical, and electrical properties of the films and to find out the optimal synthesis parameters, the oxygen content during the deposition process and the annealing temperature in air were varied in the range of 0–2 vol. % and of 200–450 °C, respectively. The characterization of the films was carried out using a 4-probe method for measuring the electrical resistance, X-ray diffraction, and optical spectroscopy of light transmission.

As a result of a comprehensive analysis of the structural, optical and electrical properties of the films, it was found that the optimal synthesis parameters to obtain the most transparent and conductive coatings promising for use as humidity, gas sensors and in photovoltaic devices are the following: oxygen content in argon plasma during sputtering process is ≈ 0,8–1,2 vol. %, the annealing temperature in air is ≈ 350–375 °C. In this case a polycrystalline film with high electrical conductivity and high transmittance in the visible and UV regions of the electromagnetic spectrum with prevailing of tin dioxide phase with structural defects (oxygen vacancies) is formed.
Spectral Method of Measuring of Changes in Time Intervals between Periodic Pulse Sequences
Authors: Sheinikov A. A. , Isaev A. V. , Zelenko V. V. , Sukhodolov Yu. V.
Published: June 2019

Methods of measuring delay time between periodic sequences of pulses are mostly based on the considered parameter direct measurement. The main disadvantage of this approach is the difficulty of ensuring the measurements accuracy in the noise conditions. The aim of this work was to develop a method that provides the ability to accurately measure small changes in time intervals, based on the analysis of the dynamic properties of the spectrum of the delayed measurement signals sum.

The developed method essence is to replace the insensitive registration of changes in the delay time between periodic pulses sequences, registration of changes in the parameters of the characteristic harmonic components of the spectrum of the resulting sum of these signals. In this case, only those harmonic components were taken into consideration that have a maximum sensitivity to delay time deviations and a minimum sensitivity to uncorrelated signal parameters changes.

To achieve the maximum effect, the influence of the pulse shape of periodic sequences on the measurement accuracy was investigated. Moreover, the trapezoidal form of impulses was taken as the basic as the most common, into which all other forms of impulses can be reborn (triangular, rectangular, sinusoidal, etc.).

The calculation results showed the effectiveness of the proposed method in order to reduce the measurement error of small changes in time intervals. In this case, the attenuation error coefficient compared with the existing measurement method amounted to Kwe = 4,78. Using the proposed approach opens up the possibility of improving the algorithmic support of measuring instruments in order to automate them and increase the measurements accuracy.
Technique for Measuring the Internal Diameter and Area of Visible Vessels of the Eye
Authors: Firago V. A. , Kubarko A. I.
Published: June 2019

The study of the effects on the microvasculature of various vasoactive drugs requires appro-priate methods and equipment for determining the basic physiological parameters of small blood vessels: their internal diameter and cross-sectional area, specific density, and blood flow velocity. Therefore, the purpose of the article is to study the possibilities of improving the reliability of determining the internal diameter and cross-sectional area of the visible blood vessels of bulbar con-junctival of the eye.

A technique for obtaining digital video recordings of the bulbar conjunctiva of the eye, based on the pulse illumination of the study area, is proposed. A prototype of the equipment with a spatial resolution of 2 µm video is described, which allows to trace all visible blood vessels, including capillaries. An algorithm for stabilizing the position of a sequence of digital images of the bulbar conjunctiva relative to the first frame is discussed. It is based on the use of subpixel interpolation when searching for a global minimum of the standard deviation of the differences in brightness of the first and selected frame.

The proposed algorithms for tracing the vascular pattern and determining the internal diameter and cross-sectional area of the blood vessels are described. An original method for calculating them is proposed, which is based on determining the area and height of a cross section of a blood vessel image. The problem of verification of the obtained results is discussed.

The described approach to make it possible to create diagnostic images of the visible blood vessels of the bulbar conjunctiva, including the capillaries, with an indication of their diameters. Examples of the construction of histograms of the distribution of the internal diameter and cross-sectional area of these blood vessels are presented.

The proposed technique and hardware solutions have the prospect of being used in creating equipment for complex non-invasive diagnostics of the microvasculature and monitoring the effectiveness of treating various diseases of the cardiovascular system, since the conditions of the eye blood vessels correlate with the state of the blood vessels in other organs.
TIMP-2 secreted by monocytes is a potent suppressor of invadopodia formation in pancreatic cancer cells
Authors: Benzing Christian , Lam Hoyin , Tsang Chi Man , Arroyo-Berdugo Yoana , Calle-Patino Yolanda , Wells Claire
Published: June 2019

Background
Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invasion have not been fully established.
Methods
In this in vitro study, to specifically test the impact of interaction on invasive potential, two PDAC cell lines PaTu8902 and CFPAC-1 were selected on their ability to form invasive adhesions, otherwise known as invadopodia. Co-culture experiments were performed using undifferentiated THP1 monocytes.
Results
When the PDAC cells were co-cultured with undifferentiated THP1 monocytes invadopodia formation was significantly suppressed. Moreover, conditioned media of THP1 cells (CM) was also able to suppress invadopodia formation. Further investigation revealed that both tissue inhibitor of metalloproteinase (TIMP) 1 and 2 were present in the CM. However, suppression of invadopodia formation was found that was specific to TIMP2 activity.
Conclusions
Our findings indicate that TIMP2 levels in the tumour microenvironment may have prognostic value in patients with PDAC. Furthermore, activation of TIMP2 expressing monocytes in the primary tumour could present a potential therapeutic opportunity to suppress cell invasion in PDAC.
A Post-Method Condition Analysis of Using Ensemble Machine Learning for Cancer Prognosis and Diagnosis: a systematic review
Authors: Kavousi Kaveh , Mirsadeghi Leila , Hosseini Reza Haji , Banaei-Moghaddam Ali Mohammad , Beh-Afarin Seyed Reza
Published: June 2019

Background

Ensemble methods are supervised learning approaches that integrate different types of data or multiple individual classifiers. It has been shown that these methods can improve professional performance.

Methods

This study is an attempt to provide an in-depth review on 45 most relevant articles and aims to introduce 42 ensemble classifier (EC) machine learning methods used for the detection of 18 different types of cancer. Compared to other types of cancer, breast cancer, and the 22 ensemble methods introduced for its identification, is extensively investigated. The purpose of this study was to identify, map, and analyze the current academic discourse on EC machine learning methods in order to: 1. identify overarching themes emerging from empirical studies regarding EC methods, 2. determine their input data and decision-making strategies, and 3. evaluate relevant statistical procedures.

Results

By comparing various approaches, we can introduce Relevance Vector Machine (RVM)-based ensemble learning method that can provide optimal solutions for problems such as curse the dimensionality and high-dimensionality of feature space without missing data values.

Conclusions

To obtain robust performance and achieve better results, it is tactfully suggested to use multi-omics data integration, which has demonstrated to identify cancers and their subtypes more efficiently.
Understanding Family Caregivers’ Needs to Support Relatives with Advanced Disease at Home: An Ethnographic Study in Rural Portugal
Authors: Teixeira Maria Joao Cardoso , Abreu Wilson , Costa Nilza , Maddocks Matthew
Published: June 2019

Background

Family caregivers play an important role supporting their relatives with advanced progressive disease to live at home. There is limited research to understand family caregiver needs over time, particularly outside of high-income settings. The aim of this study was to explore family caregivers’ experiences of caring for a relative living with advanced progressive disease at home, and their perceptions of met and unmet care needs over time.

Methods

An ethnographic study comprising observations and interviews. A purposive sample of 10 family caregivers and 10 relatives was recruited within a rural area in the north of Portugal. Data were collected between 2014-16 using serial participant observations (n=33) and in-depth interviews (n=11). Thematic content analysis was used to analyse the data.

Results

Five overarching themes were yielded: (1) provision of care towards independence and prevention of complications; (2) perceived and (3) unknown caregiver needs; (4) caregivers’ physical and emotional impairments; and (5) balancing limited time. An imbalance towards any one of these aspects may lead to reduced capability and performance of the family caregiver, with increased risk of complications for their relative. However, with balance, family caregivers embraced their role over time.

Conclusions

Our findings enhance understanding around the needs of family caregivers, which are optimally met when professionals and family caregivers work together with a collaborative approach over time. Patients and their families should be seen as equal partners. Family-focused care would enhance nursing practice in this context and this research can inform nursing training and educational programs.
Team-Based Learning Student Assessment Instrument (TBL-SAI) for measuring the effectiveness of TBL in a Saudi Medical School: Psychometric Analysis and differences by academic years
Authors: Ibrahim Mutasim E
Published: June 2019

Background

Increasing the use of Team Based Learning (TBL) in health profession education reinforce the need to develop a proper instrument for measuring the applicability of this method. This study aimed to examine the psychometric properties of TBL-SAI and the mean score of instrument subscales by the different academic year of the students.

Methods

Across-sectional study was conducted at the University of Bisha, College of Medicine (UBCOM), Saudi Arabia. Medical students from second to fourth were included in the study. Participants were completed the TBL-SAI items to measure three subscales of accountability, preference for a lecture or TBL and satisfaction. Cronbach’s alpha, factor analysis, were checked the reliability and validity of the instrument. A principal component analysis (PCA) with varimax rotation was conducted on each subscale. ANOVA analyzed the TBL effectiveness related to the different years of medical school.

Results

Cronbach’s alpha was 0.798 and factor loading was greater than 0.40 for all the items, indicating the reliability and validity of the scale. In a PCA, accountability items generated two factors with loading >0.40, except items one and four. All preference and satisfaction items have factors loading > 0.40. Fourth-year students’ obtained significant highest mean scores for accountability (p=0.0.49), preferences (p=0.001) and satisfaction (p<0.001) compared to third and second years students.

Conclusions

TBL-SAI is a sound tool to measure the favor of TBL among medical students. Longitudinal studies are recommended to bring a clear picture of the effectiveness of TBL in UBCOM.
Effect and mechanism of YH0618 granule on chemotherapy- induced hair loss in patients with breast cancer: study protocol for a randomized, double-blind, multi-center clinical trial
Authors: You Jie-shu , Guo Li , Huang Mei , Shi Xin-lei , Lin Man-di , Guo Zhen , Cao Ya-li , Sun You-zhi , Xu Qian , Qu Wei-ling , Liu Huan-lan , Lin Yi , Chen Qian-Jun , Chen Jianping
Published: June 2019

Background: Hair loss is one of the most common side effects of chemotherapy, which can cause persistent negative emotions, further affecting therapeutic effects and reducing the quality of life. However, there is no clinically safe and effective methods to solve the problem at present. Our previous clinical and animal studies showed that a medicinal and edible decoction YH0618 could significantly promote hair growth in cancer patients after chemotherapy, without interfering with the anti-tumor effect of chemotherapy. Besides, the theory of Chinese Medicine believes “Essence of the kidney is reflected on the hair”. Therefore, this study will further explore the efficacy of YH0618 granule on chemotherapy-induced hair loss in patients with breast cancer by a randomized, double-blind, multi-center clinical trial and elucidate the potential mechanism from the aspect of kidney deficiency or renal dysfunction.
Methods/Design: Eligible breast cancer patients who will start chemotherapy will be randomly divided into group A (YH0618 granule) and group B (placebo). The chemotherapeutic agents contains Taxanes or/and Anthracyclines, and chemotherapy regimen will last at least 6 cycles with every three weeks a cycle. Subjects assigned to group A will receive YH0618 granules two times a day (6 g each time), 6 days a week, mixing with 300 ml warm water from the first to the fourth chemotherapy cycle. Subjects in group B will receive the placebo granule in the same manner. The primary outcome is the time point of occurrence of hair loss reaching grade II assessed by WHO Toxicity Grading Scale, and objective indexes of hair quality and hair follicle recorded by a hair and scalp detector before the fifth chemotherapy. Secondary outcomes include changes of facial color and thumbnails color, grading of thumbnails ridging, assessment of quality life, fatigue, routine blood test, hepatic and renal function, and some medical indicators which can reflect kidney deficiency in Chinese Medicine.
Discussion: This research is of great significance for the treatment of cancer and improving the quality of life of patients. The study may provide the most direct evidence for meeting clinical needs and lay a solid scientific foundation for later product development.
Trial registration: The trial was registered on 14 December 2018 at Chinese Clinical Trial Registry: ChiCTR1800020107.
Aortocaval compression resulting in sudden loss of consciousness and severe bradycardia and hypotension during cesarean section in a patient with subvalvular aortic stenosis
Authors: Chen Shouming , Wu Lan , Jiang xiaoqin
Published: June 2019

Background

Maternal cardiac arrest during cesarean section (CS) is an extremely rare but devastating complication. Preventing emergency events from developing into maternal cardiac arrest is one of the most challenging clinical scenarios.

Case presentation

A 35-year-old pregnant woman with subvalvular aortic stenosis who was scheduled for elective CS under epidural anesthesia, and experienced devastating supine hypotensive syndrome, but was successfully resuscitated after delivery.

Conclusions

The performance of tilt position strictly or high-quality continue manual left uterine displacement (LUD) should be performed until the fetus is delivered, otherwise timely delivery of the fetus may be the best way to optimize the deadly condition.
A Test Method to Evaluate Salt Tolerance of Ornamentals
Authors: Moore Kimberly , Wajsbrot Charles , Burgart Cristina , Fisher Luci
Published: June 2019

Because salts in irrigation water decrease plant growth, we wanted to develop a quick and easy method for evaluating salt tolerance that could be used in the greenhouse. Using plastic containers with lids, sea salt, and rooted cuttings, we monitored changes in plant quality, growth, and leaf water potential as electrical conductivity (EC) and sodium (Na) levels increased. In the first of two experiments, we compared sea hibiscus (Hibiscus tilliaceus) leaf water potential and plant quality in solutions with an EC of 0, 2.1, 4.2, 6.1, or 8.2 dS·m−1 (0, 240, 420, 610, or 1010 mg·L−1 Na). After 14 days, sea hibiscus quality in solutions with an EC of 6.1 or 8.2 dS·m−1 was less than plants in solutions of 0, 2.1, or 4.2 dS·m−1. There was no difference in quality among plants in 0, 2.1, or 4.2 dS·m−1 solutions. To test this method, in Expt. 2, we compared coleus (Coleus ×hybridus), copperleaf (Acalypha wilkesiana), ficus (Ficus benjamina), jasmine (Jasminium multiflorum), and plumbago (Plumbago auriculata) plant quality and growth in solutions with an EC of 0, 1.3, 2.1, 4.2, 5.6, or 6.1 dS·m−1 (0, 170, 240, 420, 520, or 610 mg·L−1 Na). Coleus quality declined at an EC greater than 1.3 dS·m−1, whereas jasmine and plumbago quality declined at an EC greater than 2.1 dS·m−1 Copperleaf and ficus declined at an EC greater than 4.2 dS·m−1. Plant response did vary with low to medium salt-tolerant plants tolerating at an EC up to 1.3 and 170 mg·L−1 Na, whereas plants with a greater salt tolerance tolerated at EC and Na values up to 4.2 dS·m−1 and 420 mg·m−1 Na, respectively. The use of this method benefits growers by determining upper EC and Na limits when faced with poor-quality water resulting from saltwater intrusion or when using reclaimed wastewater with greater EC and Na levels.
Networks of Canadian Business Elites: Historical Corporate Interlock Networks circa 1912
Authors: MacKay Jon
Published: June 2019

This paper provides details about a historical dataset of Canadian corporations and business elites who served on corporate boards circa 1912. The source of this corporate interlock data is the Directory of Directors in Canada, 1912, a public domain volume listing Canadian public companies in Canada. Because these data are thought to be of interest not only to network researchers, but also to business historians and management scholars, an attempt has been made to make the data as easy to use as possible. Supplementary information has also been added to the network files provided. All of the individuals and companies in the dataset have been geolocated. The proper 1911 Census Division a company was located in has also been added so that the networks can be combined with other publicly available data from the period. Two sets of graph files are provided in CSV format with other formats provided on the author’s website. The first file contains corporations as the nodes with directors as edges. The second file has the individual directors as nodes and edges connecting them are corporate boards individuals both sat on.
A new HGA-FLVQ model for Mycobacterium Tuberculosis detection
Authors: Charibaldi N. , Harjoko A. , Azhari  , Hisyam B.
Published: June 2019

This research aims at develop an MTB detection model from the FLVQ neural network to HGA-FLVQ model. In this research, the FLVQ method was developed through strengthening its initiation, in which the first cluster centers used as FLVQ input were optimized first by HGA. The results show that sensitivity and specificity of the HGA-FLVQ model reach 96.30 and 95.65%, whereas the sensitivity of an FLVQ method is 70.83%, and the sensitivity of an LVQ method is 87.50%. The specificity of an FLVQ method and the specificity of an LVQ method are 84.62%. Based on these results, we can say that the HGA-FLVQ model is better than FLVQ and LVQ methods. It also means that relative amplitude can be used by the HGA-FLVQ model as a feature to detect the presence of MTB in the sputum of TB-suspected patients. Thus, the HGA-FLVQ model can be used to strengthen TB laboratory examination at Public Health Centers in Indonesia.
ECG Decision Support System based on feedforward Neural Networks
Authors: Lassoued Hela , Ketata Raouf , Yacoub Slim
Published: June 2019

The success of an Electrocardiogram (ECG) Decision Support System (DSS) requires the use of an optimum machine learning approach. For this purpose, this paper investigates the use of three feedforward neural networks; the Multilayer Perceptron (MLP), the Radial Basic Function Network (RBF), and the Probabilistic Neural Network (PNN) for recognition of normal and abnormal heartbeats. Feature sets were based on ECG morphology and Discrete Wavelet Transformer (DWT) coefficients. Then, a correlation between features was applied. After that, networks were configured and consequently used for the ECG classification. Next, with respect to the performance criteria fixed by the DSS users, a comparative study between them was deduced. Results show that for classifying the MIT-BIH arrhythmia database signals, the RBF (ACC = 99.9%) was retained as the most accurate network, the PNN (Tr_ttime = 0.070 s) as the rapidest network in the training stage and the MLP (Test_time = 0.096 s) as the rapidest network in testing stage.
GAZETECİNİN BAŞKA İŞTE ÇALIŞMA SERBESTİSİ VE SINIRLARI: BASIN İŞ KANUNU'NUN 13. MADDESİ KAPSAMINDA BİR İNCELEME
Authors: KÖME AKPULAT Ayşe
Published: June 2019

Basın Mesleğinde Çalışanlarla
Çalıştıranlar Arasındaki Münasebetlerin Tanzimi Hakkında Kanun 1952 yılında
yürürlüğe girmiştir. 5953 sayılı bu Kanun, kısaca Basın İş Kanunu olarak
adlandırılır. Basın İş Kanunu, bu alanda özel bir kanun olarak gazetecilerin
çalışma yaşamına ilişkin kuralları ve özellikle iş sözleşmesinden doğan hak ve
borçları düzenlemiş ancak gazetecilerin çalışma yaşamına ilişkin bir takım
uygulama sorunlarını çözmekte de yetersiz kalmıştır. Bunun yanında çalışma
hayatını düzenleyen bir çok kanun değiştirilmiş ancak Basın İş Kanunu günümüz
çalışma ilişkilerindeki değişime rağmen yürürlükte kalmıştır. Gazeteci, basın
iş sözleşmesiyle bir işverenin işyerinde çalışmaya başlamasından sonra
sözleşmenin devamı süresince, taraflar arasında kurulan sözleşmenin doğurduğu
güven ilişkisi gereğince işverene karşı sadakat borcu altındadır. Ancak anılan
kanunun konuya ilişkin 13. maddesinde, gazetecinin başka bir işte
çalışabileceği açıkça düzenlenmiştir. Bu çalışmada, özellikle 5953 sayılı Basın
İş Kanunu'nun 13. maddesi ve konuyla ilgili diğer düzenlemeler üzerinde
durulmuştur. Bu çerçevede, konunun önemli noktaları açıklanmış, gazetecilerin
çalışma hayatından kaynaklanan sorunları incelenmiş ve çeşitli eleştiriler
yapılmış, çözüm önerileri sunulmuştur.
Results of the use of trastuzumab combined with different chemotherapy regimens in first-line treatment of HER2-positive disseminated gastric cancer
Authors: Besova N. S. , Titova T. A. , Bagrova S. G. , Obarevich E. S. , Gorbunova V. A. , Artamonova E. V.
Published: June 2019

Gastric cancer (GC) is one of the most common types of malignant tumour worldwide and is ranked fifth in the cancer incidence pattern and third in the cancer mortality pattern. In the Russian Federation, 39.9% of patients are diagnosed with stage IV gastric cancer, 46.6% of patients die within the first year after diagnosis. The combinations of trastuzumab with platinum derivatives and fluoropyrimidines (trastuzumab + doublet) are regarded as the standard therapy against HER2 positive disseminated gastric cancer. We studied the efficacy and toxicity of the combination of trastuzumab with three-component (triple) chemotherapy regimens (docetaxel or irinotecan + platinum derivatives and fluoropyrimidines). In combination of trastuzumab with triplet chemotherapy, an objective response was achieved in 76.7% of cases, with doublet chemotherapy it was achieved in 60% (p = 0.228), of which complete tumour regression was observed in 10%, control of the disease was reported in 96.7% and 95.0 % (p = 1.0) patients, respectively. The median progression-free survival in patients, who received trastuzumab in combination with triplet chemotherapy, was 9.66 months, in combination with doublet chemotherapy was 11.07 months, the difference was not statistically significant (p = 0.800; OR = 0.908; 95% CI: 0.430–1.918). Median survival of patients is not achieved. The obtained results showed that adding a third cytostatic agent to the standard duplet chemotherapy in combination with trastuzumab does not lead to improvement in the treatment outcomes of first-line therapy in patients with HER2-positive disseminated gastric cancer.
New opioid analgesic tapentadol in the treatment of neuropathic pain in oncology
Authors: Sarmanaeva R. R. , Abuzarova G. R. , Gameeva E. V.
Published: June 2019

Famous and familiar analgesics are being replaced by new drugs with improved properties. How to calculate their dose, in which category of patients to use, for what type of pain, with what dose to start therapy and with what adjuvants to combine? Many questions arise when a new opioid is being used. To answer these difficult questions, we decided to share our experience with the new analgesic tapentadol, describing real clinical cases from our practice.
Erlotinib in combined therapy of common lung adenocarcinoma in the presence of EGFR gene mutation
Authors: Orlov S. V. , Lozhkina A. M. , Odintsova S. V. , Sviridenko M. A. , Cheremnykh A. O. , Urtenova M. A. , Filippova E. A.
Published: June 2019

The article presents data on the efficacy of erlotinib in the treatment of NSCLC in the presence of EGFR gene mutation. Its advantages over chemotherapy in terms of survival, quality of life, and tolerability of treatment, both as monotherapy and in combination with cytostatics and other targeted drug – VEGF inhibitor – Bevacizumab, are shown. A clinical case of EGFR-positive NSCLC and its treatment with erlotinib was considered. Ways of overcoming resistance to treatment are studied. The use of erlotinib should be considered as one of the standard methods of first and subsequent therapy in patients with NSCLC in later stages with confirmed mutations of the EGFR gene.
Efficacy and safety of adjuvant ovarian suppression with Buserelin-depo in premenopausal women with hormone-positive breast cancer
Authors: Ovchinnikova L. K. , Belko A. D.
Published: June 2019

Breast cancer (BC) ranks first in the morbidity pattern among women in Russia. Adjuvant endocrinotherapy is an important step in the complex treatment of premenopausal patients with hormone-positive early breast cancer. The drug ovarian suppression with GnRH-agonists have supplanted surgical castration and radiation-based treatment of the ovaries in patients with hormone-positive early breast cancer. Today, several drugs authorised for the treatment of breast cancer are used in clinical practice: goserelin, buserelin and triptorelin. Buserelin-depo is an effective method for achieving ovarian suppression. The results obtained do not differ from similar indicators obtained in using imported LHRH analogues.
SPACE-TIME EQUIVALENTS OF IONOSPHERIC ERRORS ON GLONASS POSITIONING
Authors: Baburov V. I. , Vasileva N. V. , Ivantsevich N. V.
Published: June 2019

The article analyzes statistical characteristics of the ionospheric errors of pseudoranges on GLONASS positioning their variability in space and time and establishes space‑time equivalents. These characteristics are useful to solve problems such as the choice of the fixed ground‑based reference station type, the calculation of the working area of the reference station, the effectiveness evaluation of the differential mode using in the GLONASS receivers and in the study of other options for relative GNSS positioning. To  obtain  the statistical characteristics of the ionosphere  influence  on  the  GLONASS  positioning accuracy were  conducted, simulation modeling, in which the user was located on the Earth’s surface at a point with random coordinates. Moments of time and characteristics of solar activity were also chosen randomly from the intervals of their possible change. The positioning errors, the single and double differences of pseudoranges formed in a certain way were calculated. The results are presented in the form of probability distributions of ionospheric errors and their statistical characteristics –  mean and standard deviation. Space‑time equivalents are determined.
ANALYSIS OF ACCURACY OF SPATIAL SYNCHRONIZATION OF TEMPORAL POSITION OF SIGNALS OF PULSED PHASED ANTENNA ARRAY OF SUBNANOSECOND RANGE IN PRESENCE OF RANDOM CHANNEL DELAYS
Authors: Flerov A. N. , Flerova A. A.
Published: June 2019

The structure of the pulsed phased antenna array (PPAA) of the sub nanosecond range with the system of automatic synchronization  of the temporal position of the emitted ultra short pulses is presented. The analysis of the causes and the quantitative estimation of the instrumental error of the PPAA channels has been carried out. The partial contribution to the instrumental error of the  channel functional nodes is estimated. Mathematical modeling has been carried out in order to assess the effect of channel delay  spread on the total intensity of the emitted signal for the Gaussian and normal laws of their distribution. An acceptable range of variation of channel delay values is determined, correlated to the duration of the pulses emitted by the antenna modules, with an  acceptable reduction in the quality of their spatial synchronization. The locations of possible localization in the PPAA structure of  temporal modulators intended for the initial alignment of channels and electronic scanning by the beam of the radiation pattern are indicated. The requirements for the parameters of splitter modulators are formulated. The simulation results are confirmed  by experimental studies.
Structured Telephone Support Intervention: Improved Heart Failure Outcomes
Authors: Johansson Marcia , Athilingam Ponrathi
Published: June 2019

Background

Presently, 6.5 million Americans are living with heart failure (HF). These patients are expected to follow a complex self-management regimen at home. Several demographic and psychosocial factors limit patients with HF in following the prescribed self-management recommendations at home. Poor self-care is associated with increased hospital re-admissions. Under the Affordable Care Act, there are financial implications related to hospital re-admissions for hospitals and programs such as the Program of All-Inclusive Care for the Elderly (PACE) in Pinellas County, Florida. Previous studies and systematic reviews demonstrated improvement in self-management and quality of life (QoL) in patients with HF with structured telephone support (STS) and short message service text messaging (SMS).

Objective

This study aimed to evaluate the effects of STS and SMS on self-care, knowledge, medication adherence, and QoL of patients with HF.

Methods

A prospective quality improvement project using a pre-post design was implemented. Data were collected at baseline, 30 days, and 3 months from 51 patients with HF who were enrolled in PACE in Pinellas County, Florida. All participants received STS and SMS for 30 days. The feasibility and sustained benefit of using STS and SMS was assessed at a 3-month follow-up.

Results

A paired t test was used to compare the mean difference in HF outcomes at the baseline and 30-day follow-up, which demonstrated improved HF self-care maintenance (t49=0.66; P=.01), HF knowledge (t49=0.71; P=.01), medication adherence (t49=0.92; P=.01), and physical and mental health measured using Short-Form-12 (SF-12; t49=0.81; P=.01). The results also demonstrated the sustained benefit with improved HF self-care maintenance, self-care management, self-care confidence, knowledge, medication adherence, and physical and mental health (SF-12) at 3 months with P<.05 for all outcomes. Living status and social support had a strong correlation with HF outcomes. Younger participants (aged less than 65 years) performed extremely well compared with older adults.

Conclusions

STS and SMS were feasible to use among PACE participants with sustained benefits at 3 months. Implementing STS and SMS may serve as viable options to improve HF outcomes. Improving outcomes with HF affects hospital systems and the agencies that monitor and provide care for outpatients and those in independent or assisted-living facilities. Investigating viable options and support for implementation will improve outcomes.
Clinical Applications of Mobile Health Wearable–Based Sleep Monitoring: Systematic Review (Preprint)
Authors: Guillodo Elise , Lemey Christophe , Simonnet Mathieu , Walter Michel , Baca-García Enrique , Masetti Vincent , Moga Sorin , Larsen Mark ,   HUGOPSY Network, Ropars Juliette , Berrouiguet Sofian
Published: June 2019

BACKGROUND

Sleep disorders are a major public health issue. Nearly 1 in 2 people experience sleep disturbances during their lifetime, with a potential harmful impact on well-being and physical and mental health.

OBJECTIVE

The aim of this study was to better understand the clinical applications of wearable-based sleep monitoring; therefore, we conducted a review of the literature, including feasibility studies and clinical trials on this topic.

METHODS

We searched PubMed, PsycINFO, ScienceDirect, the Cochrane Library, Scopus, and the Web of Science through June 2019. We created the list of keywords based on 2 domains: wearables and sleep. The primary selection criterion was the reporting of clinical trials using wearable devices for sleep recording in adults.

RESULTS

The initial search identified 645 articles; 19 articles meeting the inclusion criteria were included in the final analysis. In all, 4 categories of the selected articles appeared. Of the 19 studies in this review, 58 % (11/19) were comparison studies with the gold standard, 21% (4/19) were feasibility studies, 15% (3/19) were population comparison studies, and 5% (1/19) assessed the impact of sleep disorders in the clinic. The samples were heterogeneous in size, ranging from 1 to 15,839 patients. Our review shows that mobile-health (mHealth) wearable–based sleep monitoring is feasible. However, we identified some major limitations to the reliability of wearable-based monitoring methods compared with polysomnography.

CONCLUSIONS

This review showed that wearables provide acceptable sleep monitoring but with poor reliability. However, wearable mHealth devices appear to be promising tools for ecological monitoring.
Remote Patient Monitoring in Adults Receiving Transfusion or Infusion for Hematological Disorders Using the VitalPatch and accelerateIQ Monitoring System: Quantitative Feasibility Study (Preprint)
Authors: Tonino Rik Paulus Bernardus , Larimer Karen , Eissen Okke , Schipperus Martin Roelof
Published: June 2019

BACKGROUND

Frequent vital sign monitoring during and after transfusion of blood products and certain chemotherapies or immunotherapies is critical for detecting infusion reactions and treatment management in patients. Currently, patients return home with instructions to contact the clinic if they feel unwell. Continuous monitoring of vital signs for hematological patients treated with immunotherapy or chemotherapy or receiving blood transfusions using wearable electronic biosensors during and post treatment may improve the safety of these treatments and make remote data collection in an outpatient care setting possible.

OBJECTIVE

This study aimed to evaluate patient experiences with the VitalPatch wearable sensor (VitalConnect) and to evaluate the usability of data generated by the physIQ accelerateIQ monitoring system for the investigator and nurse.

METHODS

A total of 12 patients with hematological disorders receiving red blood cell transfusions, an intravenous (IV) proteasome inhibitor, or an IV immunotherapy agent were included in the study and wore the VitalPatch for 12 days. Patients completed questionnaires focusing on wearability and nurses completed questionnaires focusing on the usability of the VitalPatch.

RESULTS

A total of 12 patients were enrolled over 9 months, with 4 receiving red blood cell transfusions, 4 receiving IV proteasome inhibitors, and 4 receiving IV immunotherapy. These patients were treated for diseases such as multiple myeloma, myelodysplastic syndrome, and non-Hodgkin lymphoma. Of these patients, 83% (10/12) were aged 60 years and older. A total of 4 patients (4/12, 33%) withdrew from the study (3 because of skin irritation and 1 because of patch connection issues). Patients wore biosensor patches at baseline and for 1-week post administration. Patient-reported outcomes (PROs) were collected at baseline, day 1, day 5, and day 8. No difference in the PRO was observed when nurses or patients applied the patch. PRO data indicated minimal impact on the patient’s life. Ease of use, influence on sleep, impact on follow-up of health, or discomfort with continuous monitoring did not change between baseline and day 8. Changes in PRO were observed on day 5, where a 20% (2/10) increase in skin irritation was reported. Withdrawals because of skin irritation were reported in all cases when wearing the second patch. Nurses reported the placement of the VitalPatch to be easy and felt measurements to be reliable.

CONCLUSIONS

Generally, the VitalPatch was well tolerated and shown to be an attractive device because of its wearability and low impact on daily activities in patients, therefore making it suitable for implementation in future studies.
PROTOKOL ROUTING PADA VANET: TAKSONOMI DAN ANALISIS PERBANDINGAN ANTARA DSR, AODV, DAN TORA
Authors: Aziza Rosida Nur , Siswipraptini Puji Catur , Cahyaningtyas Rizqia
Published: June 2019

VANET yang merupakan bagian dari MANET  adalah teknologi yang memungkinkan komunikasi nirkabel antar berbagai kendaraan yang bergerak atau antara kendaraan dengan unit komunikasi yang terdapat di sepanjang  jalan.  VANET dikembangkan untuk mendukung ITS  dalam meningkatkan keselamatandi  jalan raya dan efisiensi lalu lntas.  Jaringan ad-hoc ini juga dirancang untuk memungkinkan pertukaran pesan-pesan peringatan antar kendaraan untuk meningkatkan keselamatan penumpang dan informasi-informasi lain terkait dengan aplkasi dan layanan VANET. Untuk mewujudkan hal tersebut, ada beberapa hal yang perlu dipertimbangkan supaya VANET dapat beroperasi denganbaik. Hal-hal tersebut antara lain  masalah keterbatasan bandwidth, keamanan, skalabilitas, protokol kendali akses media (MAC) dan mekanisme routing. Ada beberapa karakteristik khusus dari  VANET yang perlu diperhatikan oleh protokol routing, antara lain :  mobilitas node yang tinggi, jumlah dan kepadatana node yang tidak tetap, dan topologi jaringan yang terus berubah.  Diperlukan protokol routing tertentu untuk  mewujudkan komunikasi yang handal, kontinyu dan tanpa batas antar node pada VANET.  Secara garis besar, protokol  routing pada VANET dikelompokkan menjadi dua: kelompok protokol yang berdasarkan posisi kendaraan dan kelompok yang berdasar pada topologi jaringan. Tulisan ini akan membahas mengenai protokol routing DSR, AODV, TORA dan menjelaskan bagaimana ketiga protokol reaktif ini menjalankan mekanisme routing pada VANET. Kelebihan dan kekurangan dari ketiga protokol tersebut juga akan dianalisis dengan didukung oleh beberapa hasil simulasi dari penelitian-penelitian yang telah dilakukan sebelumnya.
ANALYSIS STEGO-IMAGE EXTRACTION USING ROT13 AND LEAST SIGNIFICANT BIT (LSB) ALGORITHM METHOD ON TEXT SECURITY
Authors: Damanik Hillman Akhyar , Anggraeni Merry , Defisa Tomi
Published: June 2019

Cryptography is both a science and an art to keep the message confidential. While steganography is the science and art of hiding secret messages in other messages so that the existence of such secret messages is unknowable and generally serves to disguise the existence of confidential data making it difficult to detect and protect the copyright of a product. Steganography requires two properties, namely container media and secret messages. The application of steganographic and cryptographic combination is done by Least Significant Bit (LSB) and ROT13 algorithm. Steganography with the LSB method is one of the methods used to hide messages on digital media by inserting it to the lowest bits or the most right bits of the pixel data that compile the file. In this research, the authors propose the technique of securing Steganography secret messages with layered security, by adding Cryptography to secret messages that will be inserted into digital images and then messages inserted into digital images through Steganography using LSB method.
Perancangan Aplikasi Pembelajaran Bahasa Inggris Untuk Sekolah Dasar Kelas 3 Berbasis Multimedia
Authors: Budiyanto Muh. Arif , Wahab Abdi
Published: June 2019

Media pembelajaran adalah alat bantu proses belajar mengajar yang dapat dipergunakan untuk merangsang pikiran, perasaan, perhatian dan kemampuan atau ketrampilan siswa sehingga dapat mendorong terjadinya proses belajar. Pelajaran Bahasa Inggris merupakan salah satu mata pelajaran yang kurang diminati dan kurang disukai oleh para siswa di sekolah. Penelitian ini dilakukan untuk menjawab permasalahan tersebut dengan membuat media pembelajaran yang menarik dan interaktif, sehingga para siswa disekolah akan tertarik untuk belajar karena disertai dengan tampilan multimedia dan beragam animasi yang akan membuat para siswa tidak bosan dan aktif berinteraksi dengan media pembelajaran Bahasa Inggris tersebut. Dalam penelitian ini, metode yang digunakan adalah Metode Pengembangan Aplikasi Multimedia. Menurut Luther (dalam buku Sutopo, 2003) pengembangan sistem multimedia dilakukan berdasarkan enam tahap yaitu: concept, design, material collecting, assembly, testing, distribution. Dari hasil penelitian ini diharapkan akan tercipta sebuah aplikasi pembelajaran Bahasa Inggris untuk siswa Sekolah Dasar Kelas 3 yang interaktif dan berbasis multimedia. Dengan demikian para siswa di sekolah akan mendapatkan media pembelajaran baru selain yang konvensional dikelas, sehingga pembelajaran Bahasa Inggris akan bervariatif dan interaktif serta menarik untuk diikuti oleh para siswa di sekolah.
Study of the Natural Heritage Condition of the Kursiu Nerija National Park Using Lidar Technology (Case Study of Agila Dune)
Authors: Pankauskyte Deimante , Valciukiene Jolanta , Kuklys Indrius , Kukliene Lina
Published: June 2019

Analysis of the condition of the Agila dune is presented in this Article. The analysis is based on data collected during accurate geodetic measurements using LIDAR technology. The current state of the Agila dune was compared to the data of the previous year's LIDAR points in order to ensure the reliability and value of the research. In the course of the study, eleven cross sections were compared by height differences with previous year‘s measurements. The condition of the Agila dune was found to be the worst in three cross sections. First cross section‘s erosion measured at 13,98 meters, erosion in the fifth cross section – 9.90 meters, and erosion in the eighth cross section - 11.34 meters. The main reasons for the deterioration of the natural values of the Kursiu Nerija National Park are climate, wind, high visitor flows and the persistent failure to carry out comprehensive research. Therefore, in order to preserve these unique natural values, it is important to collect large-scale and high-precision data on the status of these values, to systematize, analyze and take appropriate protective measures.
Botrytis squamosa - the causal agent of onion leaf blight in Bosnia and Herzegovina
Authors: Tanovic Brankica , Koscica Milan , Hrustic Jovana , Mihajlovic Milica , Trkulja Vojislav , Delibasic Goran
Published: June 2019

Over the past several decades, necrotic spots, lesions and blight symptoms
have been observed on onion leaves in several locations in Bosnia and
Herzegovina, where the crop is grown intensively. The type of symptoms
indicated a possible infection with Botrytis squamosa, a widespread pathogen
of onion. As symptoms of leaf spots and necrotic lesions can also be caused
by some other biotic and abiotic factors, our research focused on
identifying the causal agent of the observed symptoms. The pathogen was
isolated from diseased tissue using standard phytopathological procedure and
identified based on pathogenic and morphological features. Identification
was confirmed by amplification and sequencing of the internal transcribed
spacer (ITS) region of ribosomal DNA (rDNA). The influence of temperature
and growth medium on mycelial growth rate of the isolates was also studied.