bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY ON THE SPINE HEALTH MANAGEMENT OF THE ELDERLY USING CENTER OF PRESSURE DATA
Authors: KIM KYONG , SHIN MI YEON , CHONG WOO SUK , YU CHANG HO
Published: December 2020

This study intends to develop a system for managing the health of the spinal joints of elderly people who mainly live on Korean floor heating (Ondol). The spine health management system consists of a seat cushion-type posture balance device that can measure the sitting posture, an application for smart devices capable of real-time collection of posture balance data, and a database server for analysis and visualized feedback of the data. Each force signal measured with the four load cells installed in posture balance device is wirelessly transmitted to an Arduino-based Android application, and the center of pressure (COP) value of the sitting position is analyzed using the four load cell data. To test the usability of the spinal health management system, the COP values of front, back, left and right torso tilts of healthy adults in a sitting position were measured with the posture balance device and 3D motion analysis program (Visual 3D, USA). After that, the COP values were compared and analyzed. As a result of the analysis, the COP direction data (front, back, left and right) measured with the posture balance device exactly matched the direction analyzed by the 3D motion analysis system.
A Review of the Impact of COVID-19 on Male Reproduction, and its Implications on Assisted Reproductive Technology Services
Authors: Hinting Aucky , Agustinus  , Pakpahan Cennikon
Published: December 2020

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became an established pandemic in 2020. The presence of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in male reproductive organ are considered as a potential for susceptibility of these organs to SARS-CoV-2 infection.

Review: Spermatogonia are the only cells that express ACE2 and TMPRSS2 in the testis, but the cells which co-express both genes are rare (0.05% of cells). Based on this co-expression, sperm are unlikely to be susceptible to infection by SARS-CoV-2. However, the co-expression of receptor basigin (BSG/CD147) and cathepsin L (CTSL) in primary spermatocytes, Leydig cells, myoid cells, endothelial cells, and spermatogonia might increase the testicular susceptibility to this viral infection. Testicular pain and discomfort have been reported in coronavirus disease 2019 (COVID-19) patients. Postmortem examination also reported seminiferous tubular injury, reduced Leydig cells, and mild lymphocytic inflammation in COVID-19 patients. Compensated hypogonadism has been documented while the impact of COVID-19 on the semen quality is inconclusive. There is only one study that reported the presence of SARS-CoV-2 RNA in semen but, is not supported by other studies with better methods. The association between SARS-CoV-2 and assisted reproductive technology (ART) outcome is surrounded by some uncertainties. Recommendations have been made to reduce the risk of viral transmission to patients, staff, gametes, and embryos.

Summary: There is no definite correlation between SARS-CoV-2 infection and male reproductive system. However, a high level of vigilance is still required in services which involve the reproductive system.
A Patient with Finger Gangrene
Authors: Ma Kai-Yiu
Published: December 2020

The following clinical quiz demonstrates that capillaroscopy is useful in the assessment of patients suffering from Raynaud’s phenomenon in systemic sclerosis (SSc) spectrum diseases.
Advances in Microbiome Research for Animal Health
Authors: Peixoto Raquel S. , Harkins Derek M. , Nelson Karen E.
Published: December 2020

Host-associated microbiomes contribute in many ways to the homeostasis of the metaorganism. The microbiome's contributions range from helping to provide nutrition and aiding growth, development, and behavior to protecting against pathogens and toxic compounds. Here we summarize the current knowledge of the diversity and importance of the microbiome to animals, using representative examples of wild and domesticated species. We demonstrate how the beneficial ecological roles of animal-associated microbiomes can be generally grouped into well-defined main categories and how microbe-based alternative treatments can be applied to mitigate problems for both economic and conservation purposes and to provide crucial knowledge about host–microbiota symbiotic interactions. We suggest a Customized Combination of Microbial-Based Therapies to promote animal health and contribute to the practice of sustainable husbandry. We also discuss the ecological connections and threats associated with animal biodiversity loss, microorganism extinction, and emerging diseases, such as the COVID-19 pandemic.
Study on Preparation and Characterization of Graphene Based on Ball Milling Method
Authors: Huang Gang , Lv Chuncheng , He Junxi , Zhang Xia , Zhou Chao , Yang Pan , Tan Yan , Huang Hao
Published: December 2020

Taking advantage of the state-of-the-art graphene preparation technologies in China and abroad, this work studied the preparation processes of graphene for road applications based on the preliminary high-speed vibration ball milling method. This work combined numerical modeling and microscopic experiments. The preparation parameters were optimized through a multifactor and multilevel test scheme. The materials, influencing factors, and parameters in the preparation process were systematically studied. A graphene preparation method was proposed that considered vibration frequency, static filling rate, material-to-ball volume ratio, and the void percentages of media. Flake graphite, aluminum powder, and 304 stainless-steel grit were used as the preparation materials. The preparation parameters and process model were established based on the uniform design method. The preparation parameters were proposed, calculated, and optimized. Microscopic analysis showed that the proposed preparation method can improve the quality of graphene. This study provides a new source of raw materials for the application of graphene in road engineering.
A Novel TODIM with Probabilistic Hesitant Fuzzy Information and Its Application in Green Supplier Selection
Authors: Tian Xiaoli , Niu Meiling , Ma Jiangshui , Xu Zeshui
Published: December 2020

TODIM is a well-known multiple-criteria decision-making (MCDM) which considers the bounded rationality of decision makers (DMs) based on prospect theory (PT). However, in the classical TODIM, the perceived probability weighting function and the difference of the risk attitudes for gains and losses are not consistent with the original idea of PT. Moreover, probabilistic hesitant fuzzy information shows its superiority in handling the situation that the DMs hesitate among several possible values with different possibilities. Hence, a novel TODIM with probabilistic hesitant fuzzy information is proposed in this paper to simulate the perceptions of the DMs in PT. To show the advantages of the proposed method, a novel TODIM is combined with hesitant fuzzy information. Finally, a case study is carried out to demonstrate the feasibility of the proposed method, and a series of comparative analyses and the sensitivity analyses are used to show the stability of the proposed method.
Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse Model
Authors: Alqahtani Faleh , Assiri Mohammed A. , Mohany Mohamed , Imran Imran , Javaid Sana , Rasool Muhammad Fawad , Shakeel Waleed , Sivandzade Farzane , Alanazi Ahmed Z. , Al-Rejaie Salim S. , Alshammari Musaad A. , Alasmari Fawaz , Alanazi Mohammed Mufadhe , Alamri Faisal F.
Published: December 2020

Traumatic brain injury (TBI) is among the most debilitating neurological disorders with inadequate therapeutic options. It affects all age groups globally leading to post‐TBI behavioral challenges and life‐long disabilities requiring interventions for these health issues. In the current study, C57BL/6J mice were induced with TBI through the weight‐drop method, and outcomes of acutely administered ketamine alone and in combination with perampanel were observed. The impact of test drugs was evaluated for post‐TBI behavioral changes by employing the open field test (OFT), Y‐maze test, and novel object recognition test (NOR). After that, isolated plasma and brain homogenates were analyzed for inflammatory modulators, i.e., NF‐κB and iNOS, through ELISA. Moreover, metabolomic studies were carried out to further authenticate the TBI rescuing potential of drugs. The animals treated with ketamine‐perampanel combination demonstrated improved exploratory behavior in OFT (P < 0.05), while ketamine alone as well as in combination yielded anxiolytic effect (P < 0.05‐0.001) in posttraumatic mice. Similarly, the % spontaneous alternation and % discrimination index were increased after the administration of ketamine alone (P < 0.05) and ketamine‐perampanel combination (P < 0.01‐0.001) in the Y‐maze test and NOR test, respectively. ELISA demonstrated the reduced central and peripheral expression of NF‐κB (P < 0.05) and iNOS (P < 0.01‐0.0001) after ketamine‐perampanel polypharmacy. The TBI‐imparted alteration in plasma metabolites was restored by drug combination as evidenced by metabolomic studies. The outcomes were fruitful with ketamine, but the combination therapy proved more significant in improving all studied parameters. The benefits of this new investigated polypharmacy might be due to their antiglutamatergic, antioxidant, and neuroprotective capacity.
Self-Image Congruence, Functional Congruence, and Mobile App Intention to Use
Authors: Wu Shuhui , Ren Minglun , Pitafi Abdul Hameed , Islam Tahir
Published: December 2020

Although the research on the technology acceptance model (TAM) has received much attention, limited research has been done on the role of self-image congruence on the mobile application (app) intention to use. Therefore, leveraging the lens of the self-congruence theory, the primary objective of the present research is to examine the impact of self-image and functional congruence on the mobile app intention to use. We conduct a survey and collect 349 responses from Chinese smartphone users. The results of the current research reveal that self-image congruence is positively significantly related to mobile app intention to use. Also, our findings show that symbolic congruence is a vital determinant of the mobile app intention to use among Chinese smartphone users. Overall, the present study extends the understanding of TAM and concludes that symbolic congruence, such as functional attributes, is equally essential for technology intention to use. Moreover, this study extends the TAM and self-congruence theory literature by empirically investigating and validating the conceptual framework. The present study highlights the significance of self-image congruence to understand the user mobile app adoption behavior better. It provides important knowledge for the app developers, researchers, policymakers, and marketing managers of the famous social commerce and popular brand apps.
Research on Arch Model and Numerical Simulation of Critical Water and Sand Inrush in Coal Mine near Unconsolidated Layers
Authors: Zhang Guibin , Zhang Wenquan , Wang Hailong , Cao Siwen , Wu Yuliang , Wang Zaiyong
Published: December 2020

With the continuous increase of the upper limit of coal mining, in mining areas near unconsolidated layers, water and sand inrush disasters occur from time to time, seriously threatening the safety of mine production. In this paper, the process of water and sand inrush accidents induced by mining near unconsolidated layers is analyzed using mechanical analysis and numerical simulation methods, based on the principle of silo unloading and arching and combined with actual water and sand inrush characteristics; the critical water and sand inrush arching mechanism is explained. The paper also proposed and established three critical arching mechanics models (interlocking arch, bonded arch, and transition arch), deduced the mathematical expression of interlocking arch and transition arch, and obtained the critical instability conditions of the arch and its influencing factors. The research results have guiding significance for the occurrence of water and sand inrush disasters and the judgment of the degree of damage in mining near unconsolidated layers.
Chaotic Behaviors in a Nonlinear Game of Two-Level Green Supply Chain with Government Subsidies
Authors: Zhu Chang-Feng , Wang Qing-Rong
Published: December 2020

In this paper, a two-level green supply chain composed of a manufacturer and a retailer is taken as the background. Considering the consumer’s double consumption preference and the manufacturer’s green product R&D investment, a differential game model of the green supply chain under the government cost subsidy strategy is constructed. Firstly, the equilibrium points of the system are solved and their stability is discussed and analyzed. Secondly, the dynamic evolution process of Nash equilibrium under the parameters of green degree, green preference coefficient, retail channel preference coefficient, coefficient of the sensitivity of price, and adjustment speed are described by numerical simulation. The results show that the two ways of a system entering chaos are Flip bifurcation and N-S bifurcation, respectively, by 2D bifurcation graph, and it is also verified in 1D bifurcation diagram. When the bifurcation parameters are small, the system maintains Nash equilibrium stability. If the green degree of products is increased, the green preference coefficient will also increase; on the contrary, the retail preference coefficient will decrease. Research and development cost subsidy policy can effectively improve the green degree of products and increase the sales volume of products, so as to improve the profit of supply chain members.
Deep Reinforcement Learning-Based Collaborative Video Caching and Transcoding in Clustered and Intelligent Edge B5G Networks
Authors: Wan Zheng , Li Yan
Published: December 2020

In the next-generation wireless communications system of Beyond 5G networks, video streaming services have held a surprising proportion of the whole network traffic. Furthermore, the user preference and demand towards a specific video might be different because of the heterogeneity of users’ processing capabilities and the variation of network condition. Thus, it is a complicated decision problem with high-dimensional state spaces to choose appropriate quality videos according to users’ actual network condition. To address this issue, in this paper, a Content Distribution Network and Cluster-based Mobile Edge Computing framework has been proposed to enhance the ability of caching and computing and promote the collaboration among edge severs. Then, we develop a novel deep reinforcement learning-based framework to automatically obtain the intracluster collaborative caching and transcoding decisions, which are executed based on video popularity, user requirement prediction, and abilities of edge servers. Simulation results demonstrate that the quality of video streaming service can be significantly improved by using the designed deep reinforcement learning-based algorithm with less backhaul consumption and processing costs.
Effect of Implementing a Free Delivery Service Policy on Women’s Utilization of Facility-Based Delivery in Central Ethiopia: An Interrupted Time Series Analysis
Authors: Demissie Ayalneh , Worku Alemayehu , Berhane Yemane
Published: December 2020

Background. Access to and utilization of facility delivery services is low in Ethiopia. The government of Ethiopia introduced a free delivery service policy in all public health facilities in 2013 to encourage mothers to deliver in health facilities. Examining the effect of this intervention on the utilization of delivery services is very important. Objective. In this study, we assessed the effect of provisions of free maternity care services on facility-based delivery service utilization in central Ethiopia. Methods. Data on 108 time points were collected on facility-based delivery service utilization (72 pre- and 36 postintervention) for a period of nine years from July 2007 to June 2016. Routine monthly data were extracted from the District Health Information System and verified using data from the delivery ward logbooks across the study facilities. An interrupted time-series analysis was conducted to assess the effect of the intervention. Results. The implementation of the free delivery services policy has significantly increased facility deliveries. During the study period, there was a statistically significant increase in the number of facility-based deliveries after the 24th and 36th months of intervention (

p
<
0.05

). Program effects on the use of public facilities for deliveries were persisted over a longer exposure period. Conclusion. The findings suggested that the provision of free delivery services at public health facilities increased facility delivery use. The improved utilization of facility delivery services was more marked over a longer exposure period. Policy-makers may consider mobilizing the communities aware of the program at its instigation.
β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response
Authors: de B. Oliveira Ana L. , Navegantes-Lima Kely C. , Monteiro Valter V. S. , Quadros Lucas B. G. , de Oliveira Juliana P. , dos Santos Sávio M. , de A. Pontes Anna C. A. , Dorneles Gilson P. , Romão Pedro R. T. , Júnior Luiz C. R. , de Oliveira Alaíde B. , Monteiro Marta C.
Published: December 2020

Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. β-Lapachone (β-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of β-Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, β-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, β-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with β-Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the β-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus
Authors: Wang Yuyang , Wu Junfa , Xie Hongyu , Wang Liping , Wang Chuanjie , Wu Yi
Published: December 2020

Poststroke cognitive impairment severely affects the long‐term recovery of patients. However, it remains unknown whether an enriched environment can remodel contralateral hippocampal function and promote cognitive function recovery after cerebral ischemic injury. To further explore, 36 C57BL/6 mice that underwent permanent middle cerebral artery occlusion (pMCAO) were randomly assigned to three groups: enriched environment (EE), standard condition (SC), and sham surgery (Sham). After 21 days of intervention, the Morris water maze and step‐through test was utilized for testing the cognitive function of the mice, cresyl violet staining for measuring the degree of atrophy in the hippocampal tissues, and western blotting for quantitating the expression levels of GA1B, GAD67, and NR2B, and immunohistochemistry for levels of NR2B in the CA1 region of the contralateral hippocampus. The results showed that cognitive function‐related behavioral performance decreased in the SC group, and performance was better in the EE group than that in the SC group (p < 0.01); no significant difference in the degree of contralateral cerebral atrophy was observed between the EE and SC groups (p > 0.05); levels of GA1B, GAD67, and NR2B in the contralateral hippocampus were significantly higher in the EE group than those in the SC group (p < 0.01); and the level of NR2B in the CA1 region of the contralateral hippocampus significantly increased in the EE group compared to the SC group (p < 0.01). We believe that contralateral hippocampal function is inhibited after cerebral ischemic injury, further affecting cognitive function. However, enriched environment can upregulate GABAergic and glutamatergic systems in the contralateral hippocampus to promote cognitive function recovery after cerebral ischemic injury.
Measurement and Simulation for Vehicle-to-Infrastructure Communications at 3.5 GHz for 5G
Authors: Zeng Yi , Yi Haofan , Xia Zijie , Wang Shaoshi , Ai Bo , Fei Dan , Li Weidan , Guan Ke
Published: December 2020

Intelligent Transportation System (ITS) is more and more crucial in the modern transportation field, such as the applications of autonomous vehicles, dynamic traffic light sequences, and automatic road enforcement. As the upcoming fifth-generation mobile network (5G) is entering the deployment phase, the idea of cellular vehicle-to-everything (C-V2X) is proposed. The same 5G networks, coming to mobile phones, will also allow vehicles to communicate wirelessly with each other. Hence, 3.5 GHz, as the main sub-6 GHz band licensed in 5G, is focused in our study. In this paper, a comprehensive study on the channel characteristics for vehicle-to-infrastructure (V2I) link at 3.5 GHz frequency band is conducted through channel measurements and ray-tracing (RT) simulations. Firstly, the channel parameters of the V2I link are characterized based on the measurements, including power delay profile (PDP), path loss, root-mean-square (RMS) delay spread, and coherence bandwidth. Then, the measurement-validated RT simulator is utilized to conduct the simulations in order to supplement other channel parameters, in terms of the Ricean K-factor, angular spreads, the cross-correlations of abovementioned parameters, and the autocorrelation of each parameter itself. This work is aimed at helping the researchers understand the channel characteristics of the V2I link at 3.5 GHz and support the link-level and system level design for future vehicular communications of 5G.
Analysis of the Influence of Different Fracture Network Structures on the Production of Shale Gas Reservoirs
Authors: Yue Ming , Huang Xiaohe , He Fanmin , Yang Lianzhi , Zhu Weiyao , Chen Zhangxin
Published: December 2020

Volume fracturing is a key technology in developing unconventional gas reservoirs that contain nano/micron pores. Different fracture structures exert significantly different effects on shale gas production, and a fracture structure can be learned only in a later part of detection. On the basis of a multiscale gas seepage model considering diffusion, slippage, and desorption effects, a three-dimensional finite element algorithm is developed. Two finite element models for different fracture structures for a shale gas reservoir in the Sichuan Basin are established and studied under the condition of equal fracture volumes. One is a tree-like fracture, and the other is a lattice-like fracture. Their effects on the production of a fracture network structure are studied. Numerical results show that under the same condition of equal volumes, the production of the tree-like fracture is higher than that of the lattice-like fracture in the early development period because the angle between fracture branches and the flow direction plays an important role in the seepage of shale gas. In the middle and later periods, owing to a low flow rate, the production of the two structures is nearly similar. Finally, the lattice-like fracture model is regarded as an example to analyze the factors of shale properties that influence shale gas production. The analysis shows that gas production increases along with the diffusion coefficient and matrix permeability. The increase in permeability leads to a larger increase in production, but the decrease in permeability leads to a smaller decrease in production, indicating that the contribution of shale gas production is mainly fracture. The findings of this study can help better understand the influence of different shapes of fractures on the production in a shale gas reservoir.
A Fusion Multiobjective Empire Split Algorithm
Authors: Liang Liang
Published: December 2020

In the last two decades, swarm intelligence optimization algorithms have been widely studied and applied to multiobjective optimization problems. In multiobjective optimization, reproduction operations and the balance of convergence and diversity are two crucial issues. Imperialist competitive algorithm (ICA) and sine cosine algorithm (SCA) are two potential algorithms for handling single-objective optimization problems, but the research of them in multiobjective optimization is scarce. In this paper, a fusion multiobjective empire split algorithm (FMOESA) is proposed. First, an initialization operation based on opposition-based learning strategy is hired to generate a good initial population. A new reproduction of offspring is introduced, which combines ICA and SCA. Besides, a novel power evaluation mechanism is proposed to identify individual performance, which takes into account both convergence and diversity of population. Experimental studies on several benchmark problems show that FMOESA is competitive compared with the state-of-the-art algorithms. Given both good performance and nice properties, the proposed algorithm could be an alternative tool when dealing with multiobjective optimization problems.
Quality Risk Propagation of Complex Product Collaborative Manufacturing Supply Chain Network Based on CN and SoV
Authors: Li Tengjiao , Chen Hongzhuan , Yuan Jie , Qian Jingye , Siyal Abdul Waheed
Published: December 2020

The collaborative development of complex products has gradually developed into a “main manufacturer-suppliers” mode, under which the manufacturing enterprises form a complex product collaborative manufacturing supply chain network. Quality risks which bring enormous hidden danger to the product quality can be propagated and accumulate along the supply chain. It is of great significance to quantify the propagation mechanism of quality risk between supply chain network nodes and identify the key quality risk factor that causes fluctuation of product quality. This study for the first time applies the SoV into the research on quality risk propagation of complex product collaborative manufacturing supply chain network. Firstly, this paper uses the CN to construct a complex product collaborative manufacturing supply chain network according to its characteristics. Secondly, on the basis of SoV, the quality risk propagation model is established. Thirdly, we put forward a method to identify the key quality risk factors of supply chain network based on the risk propagation effect. Lastly, a numerical simulation is given to verify the effectiveness of the model and its identification method. The results reveal that the quality risk propagation includes the vertical propagation within enterprises and the horizontal propagation from the lower-level enterprises to the upper-level enterprises of the supply chain. The quality risks of an enterprise are determined by its own quality risk factors and the quality risk passed by the lower-level enterprises.
Age and Outcome after Endovascular Treatment in Anterior Circulation Large-Vessel Occlusion Stroke: ETIS Registry Results
Authors: Finitsis Stephanos , Epstein Jonathan , Richard Sebastien , Bourcier Romain , Sibon Igor , Dargazanli Cyril , Arquizan Caroline , Anxionnat Rene , Audibert Gerard , Zhu Francois , Mazighi Mikaël , Blanc Raphael , Lapergue Bertrand , Consoli Arturo , Marnat Gaultier , Gory Benjamin ,   for the ETIS Registry Investigators
Published: December 2020

Background: Increasing patient age has been identified in clinical trials as a poor prognostic factor for functional independence after endovascular treatment (EVT) for acute ischemic stroke. These findings may not be fully generalizable to clinical practice due to strict inclusion and exclusion criteria in these trials. We aim to assess and quantify the association of patient age, especially in patients >80 and >90 years old, with functional outcome after EVT in current, everyday clinical practice. Methods: The ETIS (Endovascular Treatment in Ischemic Stroke) Registry is an ongoing, prospective, observational study of 6 comprehensive stroke centers in France. We analyzed 1,708 patients treated between January 2017 and December 2018 and assessed the association of patient age with functional outcome adjusting for demographic and procedural predictors of functional outcome. Results: The positive effect of mechanical thrombectomy diminished significantly with increasing age: compared to the 18–80 years age group, the odds for achieving a good functional outcome at 90 days after the procedure decreased in the 80–90 and >90 years groups (multilevel OR: 0.38, 95% CI: 0.28–0.51 and OR: 0.2, 95% CI: 0.09–0.45, respectively, p < 0.001). Increasing age was associated with increased mortality (multilevel OR: 2.46, 95% CI: 1.72–3.54 for the 80–90 years group and multilevel OR: 5.49, 95% CI: 2.97–10.16 for the >90 years group). Conclusion: Patient age is strongly associated with functional outcome after EVT for acute ischemic stroke. The positive effect of thrombectomy persists in older age groups, even after adjustment for prognostic factors related to poor functional outcome. Stroke physicians should provide EVT irrespective of the patient’s age.
Territórios (Re)significados de comunidades indígenas em Unidades de Conservação do Baixo Rio Negro - Am e a adoção do turismo como alternativa de renda
Authors: Dias Luana Cristina dos Santos , Cruz Jocilene Gomes da
Published: December 2020

Nos últimos anos, o crescimento de atividades turísticas desenvolvidas por comunidades indígenas, na região do Baixo Rio Negro, estado do Amazonas, tem impactado as comunidades social, cultural e economicamente. Esse cenário se origina em virtude da adoção do turismo como meio pelo qual os indígenas podem suprir suas necessidades materiais e simbólicas. Neste artigo, teve-se como objetivo central analisar a atividade turística adotada por comunidades indígenas como alternativa de renda frente aos limites de uso do território em Unidade de Conservação (UC), na região do Baixo Rio Negro, e como objetivos específicos: conhecer as estratégias da comunidade Tatuyo, relativas ao uso do território e por meio do turismo; apreender as dinâmicas do turismo estruturado pela comunidade e o “lugar” da cultura indígena na atividade. Com o intuito de refletir sobre tal cenário e propriciar algumas contribuições, o artigo traz questões relevantes no contexto do turismo amazônico: os deslocamentos de povos indígenas de suas terras para o entorno da capital do Amazonas (Manaus), a criação de comunidades indígenas em UC de Uso Sustentável e o turismo, particularmente em quatro comunidades indígenas, denominadas Núcleo Diakuru e Aldeia Tuyuka (RDS do Tupé), Comunidade Cipiá e Comunidade Tatuyo (RDS Puranga Conquista). O percurso metodológico envolve pesquisa bibliográfica, documental e de campo. Os dados obtidos evidenciam o esforço das comunidades em obter renda por meio de apresentações culturais (danças, músicas e costumes), entretanto, a atividade turística desenvolvida e as relações com os agentes e agências sociais, envolvidos direta e indiretamente na atividade, ocasionam relações assimétricas, disputa de poder e, portanto, um “modelo” insustentável para as comunidades, tanto pelos impactos negativos sobre a cultura, quanto sobre o território.
O Brasil e os brasis no Antropoceno: bifurcações à vista
Authors: Marras Stelio
Published: December 2020

Reconhecer outras figurações a povos e mundo diante do Antropoceno parece ser tarefa incontornável. Se não soubermos nomeá-los devidamente, não saberemos divisar aliados e contrários no enfrentamento de um mundo crescentemente devastado. Novas práticas devem se acompanhar de novas concepções – ambas se instruindo mutuamente. Qual mundo corresponde ao Brasil? Quais mundos podem corresponder aos brasis? É preciso revisar o futuro para dar passagem a outras bifurcações históricas. Para novos povoamentos, novas imaginações – e vice-versa.
Pão, fama e outras fomes: uma leitura de Carolina Maria de Jesus e Clarice Lispector
Authors: Hansen Marise
Published: December 2020

Em 1960, a Livraria Francisco Alves Editora lançou dois livros que se tornariam fundamentais para a literatura brasileira a partir de um cenário pós-modernista: Laços de família, de Clarice Lispector, e Quarto de despejo, de Carolina Maria de Jesus. O objetivo deste artigo é abordar as duas obras, a despeito das diferenças de gênero literário, de estilo e das problemáticas que instauram, como manifestações de um mesmo tempo, escritas por mulheres e expressivas de uma tópica da falta, que se representa como vazio ou como fome. Considerar as obras em seu contexto de criação e publicação visa ainda a compreender aspectos da representação do autor numa época de valorização do escritor e da literatura.
Phenology and mortality of embryos in a Colombian population of Nymphargus grandisonae (Anura: Centrolenidae)
Authors: Villegas-Mora Daniela , Muñoz-Acevedo Sebastian , Guevara-Molina Estefany Caroline , Vargas-Salinas Fernando
Published: December 2020

Phenology and mortality of embryos in a Colombian population of Nymphargus grandisonae (Anura: Centrolenidae). Studies of phenology and natural history of anurans provide information useful for its conservation. This is particularly important in current scenarios of emergent diseases, high rates of deforestation, and climate change. We recorded the timing of breeding of the Glass Frog Nymphargus grandisonae and its relationship to precipitation and environmental temperature for four years in a population located in the Central Andes of Colombia, South America. In addition, we recorded the causes of mortality in egg clutches of this species. We quantified infestation by fly larvae and its impact on the survival of embryos. We found that the reproductive activity of N. grandisonae (number of males calling) was seasonal and occurred in months with highest precipitation. The main cause of embryo mortality in clutches was associated with the infestation by a spittlebug fly of the genus c.f. Cladochaeta (Drosophilidae). The survival of embryos in infested clutches was significantly lower than in those clutches not infested by fly larvae. Our results provide baseline data for the monitoring of anuran population dynamics in the Andean region using the glass frog N. grandisonae as a model system.
The relationship between body and substrate color for Ambystoma altamirani (Caudata: Ambystomatidae) from the Arroyo los Axolotes, Mexico
Authors: Hernández Viridiana Villarreal , Smith Geoffrey R. , Ayala Raymundo Montoya , Lemos-Espinal Julio A.
Published: December 2020

The relationship between body and substrate color for Ambystoma altamirani (Caudata: Ambystomatidae) from the Arroyo los Axolotes, Mexico. To determine whether the coloration of Ambystoma altamirani varies and whether the color is related to the color of the salamander’s substrate, A. altamirani from the Arroyo los Axolotes, state of México, Mexico, was examined. The study was conducted from February 2018 to January 2019, and the colors classified by comparison with a standard color wheel. The most common base color was olive-green (64%) followed by black (21%). The most common color combinations were olive-green with black markings (44%), solid black (14%), and olive-green with black and yellow markings (11%). Olive-green salamanders were present in every month of the study, whereas the other base colors were found in fewer months, with the greatest diversity of base colors being observed from April to July. Olive-green, black, and “light” A. altamirani were found on dark substrates more frequently than expected based on availability compared to intermediate or light substrates. Because there is no evidence for substrate color matching, substrate selection likely is based on other environmental features.
Abstract P142: Meta-analyses Of Genome-wide Association Studies Accounting For Gene-psychosocial Factor Interactions Identify Novel Loci For Blood Pressure Traits
Authors: Fornage Myriam , Sun Daokun , Richard Melissa A , Musani Solomon K , Sung Yun Ju , Winkler Thomas W , Franceschini Nora ,   for the CHARGE Gene-Lifestyle Workgroup
Published: December 2020

Background:
Genome-wide association studies (GWAS) have identified hundreds of genetic loci for blood pressure (BP) traits and advanced our understanding of BP regulation and hypertension etiology. Psychological and social factors are known to influence BP and risk of cardiovascular diseases. Accounting for psychosocial factors may help identify BP loci and extend our knowledge of its genetic architecture.

Methods:
To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptomatology, trait anxiety, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from 5 ancestry groups.

Results:
In the combined meta-analyses of Stages 1 and 2, we identified 59 loci (p <5e-8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (
PLCL2
), synaptic function and neurotransmission (
LIN7A, PFIA2
), as well as genes previously implicated in neuropsychiatric or stress-related disorders (
FSTL5, CHODL
).

Conclusion:
These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations.
Abstract P361: Racial/Ethnic and Age Differences in Dietary Sources of Protein, NHANES, 2011 - 2016
Authors: Popp Collin J , Beasley Jeannette M , Firestone Melanie J , Russo Rienna , Yi Stella S
Published: December 2020

Background:
Dietary protein serves a pivotal role in providing the body with essential amino acids, which are required for the maintenance of body proteins, and the assimilation of structural and functional components required for basic survival. Understanding dietary protein sources can help inform intervention efforts to increase protein intake that will accommodate the growing diversity of the United States.

Objective:
The purpose of this analysis was to identify the top 10 food category sources of dietary protein by age and race and ethnicity in a nationally representative sample.

Methods:
Cross-sectional data on adults (18+ years) from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 with one 24-hour dietary recall were analyzed (n=15,697). Population proportions were calculated for What We Eat In America food categories.

Results:
The analytic sample (n=15,697) was 15.0% Hispanic (95%CI [12.1, 17.9], 65.0% to non-Hispanic White (95%CI [60.8, 69.3]), 11.5% to non-Hispanic Black (95%CI [9.1, 13.9]), 5.4% to non-Hispanic Asian (95%CI [4.3, 6.6]) and 3.1% other (95%CI [2.5, 3.6]). In all racial and ethnic groups, chicken (whole pieces) was the top-ranked source of dietary protein. In addition to chicken (whole pieces), beef (excludes ground), eggs and omelets, and meat mixed dishes food categories ranked in the top ten sources of protein for every race/ethnicity. Conversely, each race/ethnicity group had at least one food category that uniquely ranked as a top ten source (other Mexican mixed dishes, cheese, burger (single code), rice, stir-fry and soy-based dishes, and nuts and seeds). Older adults consumed the least absolute protein (71 gram per day, 95% CI: [69,73]) and energy (1819 calories, 95%CI[1779, 1860] compared to other age groups (p-value for all <0.0001).

Conclusion:
The top ten sources of protein accounted for over 40% of dietary protein irrespective of race/ethnicity or age category, having major implications for the sustainability of our nation’s food supply. Public health strategies that encourage incorporating higher amounts of protein in food preparation have the potential to shift the overall population protein intake distribution.

Funding Source:
R01HL141427
Abstract P434: Aortic Pulse Wave Velocity in Neonates: Feasibility and Comparison to Normative Data
Authors: Pagan Lassalle Patricia , Meyer Michelle L , Boggess Kim A , Stoner Lee
Published: December 2020

Introduction:
Cardiovascular disease (CVD) risk trajectory begins in early childhood and can be influenced by genetic and environmental factors. Carotid-femoral pulse wave velocity (cfPWV) is considered the gold standard for assessing CVD risk trajectory; however, there are no normative cfPWV data in children. Further, while cfPWV may be suitable for use in children, it is challenging in neonates. Brachial-femoral PWV (bfPWV), a less obtrusive measurement, may be an alternative method given the similar contours of carotid and brachial waveforms at this age. Our purpose was to: (a) use meta-regression to determine the normal rate of cfPWV progression in children, and (b) determine the feasibility of assessing bfPWV using an oscillometric technique in neonates.

Hypothesis:
We hypothesized that (a) cfPWV will increase with age, starting at birth, and (b) mean bfPWV values from neonates will overlap with the intercept (year 0) from the normative data generated from the meta-regression.

Methods:
Electronic databases were searched from inception to May 2018 for all studies in English that reported cfPWV in children (<19 y) with at least 100 participants. Random effects meta-regression was used to quantify the association between time/age (years) and cfPWV. We measured bfPWV in 5 neonates (1-2 days old; mean weight 3.65 kg [SD: 0.52 kg]) using oscillometric cuffs, attached to the upper right arm and thigh, via the VICORDER
®
.

Results:
We identified 9 studies for the meta-regression (3 longitudinal and 6 cross-sectional). The age of the participants ranged from 14.5 – 15.1 y in longitudinal studies, with a 2-5 y follow-up. The age range across the cross-sectional studies was 6-18 y. From the meta-regression, the increase in cfPWV per year (age) was 0.12 (95% CI: 0.07, 0.16) m/s. The cfPWV intercept (0 y) was 3.61 (95% CI: 3.07, 4.16) m/s. We successfully obtained acceptable quality bfPWV measurements on all neonates, with a mean bfPWV of 3.64 (95% CI: 3.31, 3.97) m/s.

Conclusion:
In children <19 years old, cfPWV increases at a rate of 0.12 m/s per year. As hypothesized, mean values of bfPWV from the neonates overlap with the intercept from the meta-regression analysis. Evaluating bfPWV using an oscillometric technique is feasible and yields comparable results to published cfPWV data in children.
Abstract P450: Radon is Associated With Clonal Hematopoiesis of Indeterminate Potential in the Women’s Health Initiative
Authors: Anthony Kurtis M , Manson Joann E , Jaiswal Siddhartha , Natarajan Pradeep , Desai Pinkal , Hayden Kathleen M , Bick Alexander G , Carty Cara L , Collins Jason M , Love Shelly-ann , Stewart James , Schwartz Gary , Reiner Alex , Whitsel Eric A
Published: December 2020

Background:
Clonal hematopoiesis of indeterminate potential (CHIP) occurs when there is expansion of leukocyte clones in the blood due to mutations in hematopoietic stem cells. CHIP is associated with a high risk of hematologic malignancy and increased risk of cardiovascular disease (CVD). Although the environmental risk factors for CHIP remain poorly understood, radon is a ubiquitous mutagen and may deliver non-negligible doses of α-radiation to bone marrow that trigger CHIP development.

Methods:
We conducted a cross-sectional study of 10,495 postmenopausal women without hematologic malignancy from the Women’s Health Initiative clinical trials and observational study (mean age: 69 years; 82% white; 9% African American; 4% Hispanic/Latina; 3% Asian). Using blood from the 1993-1998 screening visit or a subsequent annual visit, and whole genome sequence data from the Trans-Omics for Precision Medicine project, we identified CHIP using the GATK Mu TECT2 somatic variant caller, a pre-specified list of leukemogenic driver mutations in 74 genes, and a threshold variant allele fraction > 0.02. We linked geocoded participant addresses at the time of blood draw to county-level, indoor, screening radon concentrations that were predicted by the Environmental Protection Agency (EPA) in 1993 using data on indoor radon, geology, aerial radioactivity, soil parameters, and foundation types. Radon exposure was classified as follows: Zone 3 (< 2 pCi/L), Zone 2 (2-4 pCi/L), and Zone 1 (> 4 pCi/L), the level at which EPA recommends remediation. We estimated the radon-related risk of CHIP as an odds ratio (OR, 95% CI) using logistic regression with and without adjustment for study design, participant sampling, age, race/ethnicity, smoking, and other sociodemographic / behavioral covariates.

Results:
We identified CHIP in 887 (8.5% of) participants. 3106 (29.6%), 3982 (37.9%), and 3407 (32.5%) had Zone 3, 2, and 1 radon exposures. The corresponding percentage of participants with CHIP across zones was 7.6%, 8.6%, and 9.1%. Relative to participants in Zone 3, those in Zones 2 and 1 had a higher adjusted risk of CHIP: OR (95% CI) = 1.13 (0.95, 1.35) and 1.24 (1.03, 1.48).

Conclusion:
Risk of CHIP was positively associated with indoor radon concentrations in this cross-sectional study of post-menopausal women. Longitudinal study of temporally integrated, in-home radon exposures, incident CHIP, and CVD would help confirm this novel radon-CHIP association and place it in context.