bluuebunny/crossref_metadata_2025 huggingface dataset:
The Usually Invisible, Occasionally Visible, Spirits of the Dead in Early Twentieth-Century Sámi Folklore
Authors: DuBois Thomas A.
Published: September 2023

Turn-of-twentieth-century Sámi concepts of spirits of the dead are presented along with accounts of those exceptional individuals able to see, hear, interact with, and sometimes control them, particularly persons termed noaideslágáš, i.e., skilled in noaidi arts. Examples and analysis are drawn from the writings of Sámi author and scholar Johan Turi (1854–1936), contemporaneous accounts recorded by Norwegian folklorist Just Qvigstad (1853–1957), the fieldwork of Sámi legislator, educator, and folklore collector Isak Saba (1875–1921), and an 1886 anthology of Aanaar (Inari) Sámi folklore. Described with varying names and sometimes contradicting accounts, the spirits of the dead in Sámi culture during the early twentieth century could be used to protect or enhance the fortunes of the living, but could also play roles in situations of disease, misfortune, and interpersonal conflict. The various narratives recorded in the period reflect a complex fusion of Indigenous Sámi traditions with ideas stemming from various Christian denominations and the belief legends of non-Sámi neighbors in the Finnish, Norwegian, Russian and Swedish sides of Sápmi—the Sámi homeland. Spirits of the dead figure as potent, expectable, but sometimes unpredictable elements of daily life—beings that could help or harm, depending on how they were dealt with by those with whom they came in contact and those who could wield power over them, particularly noaiddit, Sámi ritual and healing specialists.
Counseling Psychological Understanding and Considerations of the Metaverse: A Theoretical Review
Authors: Lee Kunho
Published: September 2023

The COVID-19 pandemic has triggered the interest in and demand for online platforms that can replace traditional face-to-face activities. Accordingly, metaverses have been increasingly used across society, especially in the Mental health field. This broad use of metaverses is now recognized as a major trend that will drive various industries across healthcare and society. In response to this societal change, this study provides a theoretical framework for understanding and applying metaverses as therapeutic spaces in mental health fields through a conceptualization and characterization of metaverses for a range of technologies and services. The value of metaverses as a human-centered “field of experience” was identified and proposed based on the essential aspect of the user, the human being, rather than from the technology used. According to existing psychotherapeutic theories, four therapeutic concepts for the metaverse were proposed: metaverse as an “average expectable environment” in the developmental and therapeutic categories of the self, a transitional stage for adaptation to reality, a creative space for memory and communication for the self, and an expanded or “surplus” reality. This work is expected to be a useful basis for expanding new psychotherapeutic strategies and methods as therapeutic spaces for maintaining mental health through the metaverse.
A Repeated Cross-Sectional Pilot Study of Physical Activity, Levels of Depression and Anxiety during the COVID-19 Pandemic in Young Greek Adults
Authors: Skalidou Smaragda , Anestis Andreas , Skalidis Emmanouil , Kontaxi Ourania , Kyrezi Athanasia , Konstantinou Panagiota , Papadimitriou Konstantinos
Published: September 2023

Regular physical activity (PA) and, more specifically, exercise, is associated with lower levels of stress, depression, and anxiety. The aim of this repeated cross-sectional pilot study was to investigate the impact of participating in PA on the mental health of young adults in Greece during the COVID-19 pandemic. The study was carried out during two quarantine periods: Survey I on 5 May 2020, and Survey II on 30 April 2021. The Hamilton Anxiety (HAM-A) and Beck Depression Inventory-II (BDI-II) scales and the level of PA were used to assess a sample of individuals aged between 18 and 26 years old. In 2020 and 2021, a total of 268 (33.9% males) and 380 (37.1% females) subjects participated in the studies, respectively. According to the findings, the vast majority of the participants in both samples reported that they are physically active (p = 0.86), while they consider exercise as a significant health factor (p = 0.10). Moreover, anxiety levels statistically significant increased (p = 0.001), while depression levels remained relatively stable with a slight increase of approximately (p > 0.05). Additionally, in both surveys, individuals who engaged in a PA program exhibited reduced levels of depression and anxiety (p = 0.001). Also, gender appears to influence anxiety and depression levels, while a lack of exercise exacerbates these measures in both genders when compared to physically active individuals. Concludingly, it is crucial for public health strategies to include interventions that promote safe PA in the event of future lockdowns or similar emergencies.
Smart Farming Tool for Monitoring Nutrients in Soil and Plants for Precise Fertilization
Authors: Toselli Moreno , Baldi Elena , Ferro Filippo , Rossi Simone , Cillis Donato
Published: September 2023

The current political, social, and economic conditions place, more than ever, the need to sustainably supply nutrients for plants, integrating low-impact, crop-adapted, variable-rate-application fertilizer solutions, at the center of attention. Fertilization plans should be based on the monitoring of soil fertility to address the proper rate of fertilizer application along with the development of techniques able to increase nutrient uptake efficiency. Monitoring and modelling analysis of the effects of agronomic management in different pedoclimatic conditions can provide several advantages, that include higher nutrient efficiency, increase in plant growth and yield, decreased fertilization costs, increased profit, reduced environmental impact. This approach should enter into a framework of precision farming methodologies for the distribution of nutrients adopted at different levels (region, farm, field, plot), to obtain the maximum efficiency of inputs.
Role of Humic Acid on Inducing Salt Tolerance of Ivy Geranium (Pelargonium peltatum L.) Plants
Authors: Elhindi Khalid M. , Almana Fahed A. , Al-Yafrsi Mohammed A.
Published: September 2023

Saline water is used in floriculture as an alternative to freshwater in arid regions such as Saudi Arabia (SA). However, salt stress considerably accelerates serious physio-biochemical changes associated with a decline in plant establishment. Recently, humic acid (HA) foliar spraying has induced plant stress tolerance in the era of climate change; however, its precise roles in the floriculture industry within saline conditions are not yet well documented. A factorial pot experiment throughout the 2022/2023 season was conducted in the Nursery of Sustainability and Environmental Developmental Department, King Saud University, Riyadh, SA, to evaluate the potential effects of HA (0, 500, 1000 and 2000 mg/L) on growth, flowering and some physiological characteristics of Ivy geranium (Pelargoniumpeltatum) plants irrigated with saline water (230 “control”, 2000 and 4000 mg/L NaCl). Irrigation with saline water markedly inhibited plant growth, flowering attributes, the chlorophyll index, as well as macro and micro-nutrient levels, but increased the content of iron, sodium and proline in plant shoots relative to plants irrigated with non-salinized water. However, HA mainly at 1000 mg/L significantly improved plant growth, flowering capacity, nutrient status, proline accumulation and chlorophyll index under salinized or non-salinized irrigation water. Additionally, spraying of HA concentrations (500, 1000 and 2000 mg/L) under normal or salinity conditions significantly increased shoot sodium content relative to non-treated plants under such salinity levels. Our findings highlight the significance of HA concentrations (500, 1000 and 2000 mg/L) in improving the salt tolerance of Ivy geranium. Within the scarcity of irrigation water, it is recommended to irrigate Ivy geranium with saline water up to 4000 mg/L NaCl associated with spraying HA concentrations in special 1000 mg/L.
A Data Ecosystem for Orchard Research and Early Fruit Traceability
Authors: Williams Stephen Ross , Agrahari Baniya Arbind , Islam Muhammad Sirajul , Murphy Kieran
Published: September 2023

Advances in measurement systems and technologies are being avidly taken up in perennial tree crop research and industry applications. However, there is a lack of a standard model to support streamlined management and integration of the data generated from advanced measurement systems used in tree crop research. Furthermore, the rapid expansion in the diversity and volumes of data is increasingly highlighting the requirement for a comprehensive data model and an ecosystem for efficient orchard management and decision-making. This research focuses on the design and implementation of a novel proof-of-concept data ecosystem that enables improved data storage, management, integration, processing, analysis, and usage. Contemporary technologies proliferating in other sectors but that have had limited adoption in agricultural research have been incorporated into the model. The core of the proposed solution is a service-oriented API-driven system coupled with a standard-based digital orchard model. Applying this solution in Agriculture Victoria’s Tatura tree crop research farm (the Tatura SmartFarm) has significantly reduced overheads in research data management, enhanced analysis, and improved data resolution. This is demonstrated by the preliminary results presented for in-orchard and postharvest data collection applications. The data ecosystem developed as part of this research also establishes a foundation for early fruit traceability across industry and research.
The Journey to Early Identification and Intervention for Children with Disabilities in Fiji
Authors: Smith Fleur , Perera Sureni , Marella Manjula
Published: September 2023

Early identification of developmental delay or disability and access to early intervention improves outcomes for children with disabilities and their families. However, in many low- and middle-income countries, services and systems to enable timely, co-ordinated care and support are lacking. The aim of this research was to explore the experiences of families of children with developmental disabilities in Fiji in accessing services for intervention and support across sectors. This qualitative study involved conducting interviews with caregivers of children with disabilities (n = 12), and relevant key stakeholders from health, education, disability, and social support sectors (n = 17). We used journey maps to identify key stages of the families’ journeys, identify key barriers and enablers at each stage, and provide multi-sectoral recommendations for each stage. Enablers include proactive help seeking behaviours, the use of informal support networks and an increasingly supportive policy environment. Barriers to identification include a lack of awareness of developmental disabilities and the benefits of early intervention among service providers and the community. A lack of service availability and capacity, workforce issues, family financial constraints and a lack of collaboration between sectors were barriers to intervention once needs were identified, resulting in significant unmet needs and impacting inclusion and participation for children with disabilities. Overcoming these challenges requires a multi-sectoral approach.
A Media Analysis of the COVID-19 Tobacco Sales Ban in South Africa
Authors: Dare Chengetai , Vellios Nicole , Kumar Praveen , Nayak Radhika , van Walbeek Corné
Published: September 2023

The South African government introduced a nationwide lockdown in March 2020 to mitigate the spread of COVID-19. Among other restrictions, the government banned the sale of tobacco products. The ban lasted for nearly five months. We performed a Google search using the keywords smok*, puff*, lockdown, tobacco, and cigarette* for articles published in English from 23 March 2020 to 18 December 2020. This yielded 441 usable online media articles. We identified and categorised the main arguments made by proponents and opponents of the tobacco sales ban. Three themes were identified: medical, legal, and economic/financial. Legal aspects were covered in 48% of articles, followed by economic (34%), and medical aspects (18%). The media was generally ambivalent about the tobacco sales ban during the first five weeks of lockdown. Sentiment subsequently turned against the ban because the medical rationale was not well communicated by the government. There was limited empirical evidence of a link between smoking and contracting COVID-19, and the sales ban was ineffective since most smokers still purchased cigarettes. Policy framing in the media plays an important role in how the public receives the policy. Any future tobacco control policy intervention should be better considered, especially within the context that cigarettes are easily accessed on the illicit market in South Africa.
An Ontology-Based Framework for Geospatial Integration and Querying of Raster Data Cube Using Virtual Knowledge Graphs
Authors: Hamdani Younes , Xiao Guohui , Ding Linfang , Calvanese Diego
Published: September 2023

The integration of the raster data cube alongside another form of geospatial data (e.g., vector data) raises considerable challenges when it comes to managing and representing it using knowledge graphs. Such integration can play an invaluable role in handling the heterogeneity of geospatial data and linking the raster data cube to semantic technology standards. Many recent approaches have been attempted to address this issue, but they often lack robust formal elaboration or solely concentrate on integrating raster data cubes without considering the inclusion of semantic spatial entities along with their spatial relationships. This may constitute a major shortcoming when it comes to performing advanced geospatial queries and semantically enriching geospatial models. In this paper, we propose a framework that can enable such semantic integration and advanced querying of raster data cubes based on the virtual knowledge graph (VKG) paradigm. This framework defines a semantic representation model for raster data cubes that extends the GeoSPARQL ontology. With such a model, we can combine the semantics of raster data cubes with features-based models that involve geometries as well as spatial and topological relationships. This could allow us to formulate spatiotemporal queries using SPARQL in a natural way by using ontological concepts at an appropriate level of abstraction. We propose an implementation of the proposed framework based on a VKG system architecture. In addition, we perform an experimental evaluation to compare our framework with other existing systems in terms of performance and scalability. Finally, we show the potential and the limitations of our implementation and we discuss several possible future works.
Construction of Histone–Protein Complex Structures by Peptide Growing
Authors: Zsidó Balázs Zoltán , Bayarsaikhan Bayartsetseg , Börzsei Rita , Hetényi Csaba
Published: September 2023

The structures of histone complexes are master keys to epigenetics. Linear histone peptide tails often bind to shallow pockets of reader proteins via weak interactions, rendering their structure determination challenging. In the present study, a new protocol, PepGrow, is introduced. PepGrow uses docked histone fragments as seeds and grows the full peptide tails in the reader-binding pocket, producing atomic-resolution structures of histone–reader complexes. PepGrow is able to handle the flexibility of histone peptides, and it is demonstrated to be more efficient than linking pre-docked peptide fragments. The new protocol combines the advantages of popular program packages and allows fast generation of solution structures. AutoDock, a force-field-based program, is used to supply the docked peptide fragments used as structural seeds, and the building algorithm of Modeller is adopted and tested as a peptide growing engine. The performance of PepGrow is compared to ten other docking methods, and it is concluded that in situ growing of a ligand from a seed is a viable strategy for the production of complex structures of histone peptides at atomic resolution.
Cervical and Vaginal Microbiomes in Early Miscarriages and Ongoing Pregnancy with and without Dydrogesterone Usage
Authors: Gryaznova Mariya , Kozarenko Olesya , Smirnova Yuliya , Burakova Inna , Syromyatnikov Mikhail , Maslov Alexander , Lebedeva Olga
Published: September 2023

Emerging evidence suggests that the reproductive tract microbiota is a key modulator of local inflammatory and immune pathways throughout pregnancy and may subsequently impact pregnancy outcomes. In this study, our objective was to analyze the cervical and vaginal microbiomes during early pregnancy among three groups: women with healthy ongoing pregnancies, women undergoing dydrogesterone treatment, and those who experienced miscarriages. The experiment involved 51 women at 8–11 weeks of gestation. The microbiome was examined using 16S rRNA sequencing on the Ion Torrent PGM platform. Across all groups, Lactobacillus iners was predominant, suggesting that the vaginal community type CST III is common among the majority of participants. Notably, our data highlighted the significant roles of Gardnerella vaginalis and Mycoplasma girerdii in the pathogenesis of early miscarriage. Conversely, L. iners and Bifidobacterium longum have a protective effect in early pregnancy. Moreover, dydrogesterone intake appeared to influence notable differences between the cervical and vaginal microbiomes. Overall, our study enhanced our understanding of the cervical and vaginal microbiome composition in the eastern European population during early pregnancy.
Acute Glycemic Control in Prediabetes Individuals Favorably Alters Serum NLRP3 Inflammasome and Related Interleukins
Authors: Alfadul Hend , Sabico Shaun , Alnaami Abdullah M. , Amer Osama E. , Hussain Syed D. , Wani Kaiser , Clerici Mario , Al-Daghri Nasser M.
Published: September 2023

Hyperglycemia associated with prediabetes (PD) alters NLRP3 inflammasome activity and related interleukins, yet no study has evaluated the expression of the NLRP3 inflammasome complex and related interleukins in individuals with a PD condition that did or did not develop type 2 diabetes mellitus (T2DM). This study investigated the effect of 6 months of lifestyle modification on the expression of the NLRP3 inflammasome and related interleukins (1α, 1β, 18, 33 and 37) in the sera of individuals with a PD condition that did or did not develop T2DM. This interventional study included 67 Saudi adults (mean age = 41.9 ± 8.0 years, mean BMI = 33.2 ± 5.5 kg/m2). Overnight-fasting serum samples were collected at baseline and at the 6-month follow-up. Serum levels of NLRP3, capsase-1 and related ILs were analyzed at both visits using commercially available immunoassay kits. Results showed that IL-1α increased in the PD group that developed T2DM (p = 0.046), IL-33 decreased in the PD group that reverted to normal (p < 0.001) and NLRP3 decreased in the PD group that remained PD (p = 0.01). Results also showed a positive over-time correlation between NLRP3 and both IL-1α and IL-33 (p < 0.001 and p = 0.028, respectively). In conclusion, glycemic control favorably altered NLRP3 inflammasome complex activity, and lifestyle modification in PD individuals is crucial in reversing harmful metabolic and inflammatory phenotypes.
Evidence of Small Fungal Cysteine-Rich Proteins Acting as Biosurfactants and Self-Assembling into Large Fibers
Authors: Pitocchi Rossana , Stanzione Ilaria , Illiano Anna , Amoresano Angela , Tarallo Oreste , Cicatiello Paola , Piscitelli Alessandra , Giardina Paola
Published: September 2023

Fungi produce surface-active proteins, among which hydrophobins are the most characterized and attractive also for their ability to form functional amyloids. Our most recent findings show that these abilities are shared with other classes of fungal proteins. Indeed, in this paper, we compared the characteristics of a class I hydrophobin (Vmh2 from Pleurotus ostreatus) and an unknown protein (named PAC3), extracted from the marine fungal strain Acremonium sclerotigenum, which does not belong to the same protein family based on its sequence features. They both proved to be good biosurfactants, stabilizing emulsions in several conditions (concentration, pH, and salinity) and decreasing surface tension to a comparable value to that of some synthetic surfactants. After that, we observed for both Vmh2 and PAC3 the formation of giant fibers without the need for harsh conditions or long incubation time, a remarkable ability herein reported for the first time.
Effect of Combined Levothyroxine (L-T4) and 3-Iodothyronamine (T1AM) Supplementation on Memory and Adult Hippocampal Neurogenesis in a Mouse Model of Hypothyroidism
Authors: Rutigliano Grazia , Bertolini Andrea , Grittani Nicoletta , Frascarelli Sabina , Carnicelli Vittoria , Ippolito Chiara , Moscato Stefania , Mattii Letizia , Kusmic Claudia , Saba Alessandro , Origlia Nicola , Zucchi Riccardo
Published: September 2023

Mood alterations, anxiety, and cognitive impairments associated with adult-onset hypothyroidism often persist despite replacement treatment. In rodent models of hypothyroidism, replacement does not bring 3-iodothyronamine (T1AM) brain levels back to normal. T1AM is a thyroid hormone derivative with cognitive effects. Using a pharmacological hypothyroid mouse model, we investigated whether augmenting levothyroxine (L-T4) with T1AM improves behavioural correlates of depression, anxiety, and memory and has an effect on hippocampal neurogenesis. Hypothyroid mice showed impaired performance in the novel object recognition test as compared to euthyroid mice (discrimination index (DI): 0.02 ± 0.09 vs. 0.29 ± 0.06; t = 2.515, p = 0.02). L-T4 and L-T4+T1AM rescued memory (DI: 0.27 ± 0.08 and 0.34 ± 0.08, respectively), while T1AM had no effect (DI: −0.01 ± 0.10). Hypothyroidism reduced the number of neuroprogenitors in hippocampal neurogenic niches by 20%. L-T4 rescued the number of neuroprogenitors (mean diff = 106.9 ± 21.40, t = 4.99, pcorr = 0.003), while L-T4+T1AM produced a 30.61% rebound relative to euthyroid state (mean diff = 141.6 ± 31.91, t = 4.44, pcorr = 0.004). We performed qPCR analysis of 88 genes involved in neurotrophic signalling pathways and found an effect of treatment on the expression of Ngf, Kdr, Kit, L1cam, Ntf3, Mapk3, and Neurog2. Our data confirm that L-T4 is necessary and sufficient for recovering memory and hippocampal neurogenesis deficits associated with hypothyroidism, while we found no evidence to support the role of non-canonical TH signalling.
Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model
Authors: Kurahashi Toshihiro , Nishime Chiyoko , Nishinaka Eiko , Komaki Yuji , Seki Fumiko , Urano Koji , Harada Yoshinori , Yoshikawa Toshikazu , Dai Ping
Published: September 2023

The development of regenerative medicine using cell therapy is eagerly awaited for diseases such as spinal cord injury (SCI), for which there has been no radical cure. We previously reported the direct conversion of human fibroblasts into neuronal-like cells using only chemical compounds; however, it is unclear whether chemical compound-induced neuronal-like (CiN) cells are clinically functional. In this study, we partially modified the method of inducing CiN cells (termed immature CiN cells) and examined their therapeutic efficacy, in a rat model of SCI, to investigate whether immature CiN cells are promising for clinical applications. Motor function recovery, after SCI, was assessed using the Basso, Beattie, and Bresnahan (BBB) test, as well as the CatWalk analysis. We found that locomotor recovery, after SCI in the immature CiN cell-transplanted group, was partially improved compared to that in the control group. Consistent with these results, magnetic resonance imaging (MRI) and histopathological analyses revealed that nerve recovery or preservation improved in the immature CiN cell-transplanted group. Furthermore, transcriptome analysis revealed that immature CiN cells highly express hepatocyte growth factor (HGF), which has recently been shown to be a promising therapeutic agent against SCI. Our findings suggest that immature CiN cells may provide an alternative strategy for the regenerative therapy of SCI.
Potential of Static Pressure Recovery of Rotor-Only Low-Pressure Axial Fans
Authors: Witte Hauke , Bode Christoph , Friedrichs Jens
Published: September 2023

Typically installed in a rotor-only configuration, low-pressure axial fans discharge directly into a free atmosphere and the discharge shows a strong swirl component. Since such designs, without guide vanes, cannot convert the dynamic pressure in the swirl component back into static pressure, the dynamic pressure is usually considered a loss. However, the radial equilibrium shows that a significant part of the kinetic energy contained in this swirl component is recovered as static pressure in the free atmosphere. This additional pressure increase has been sparsely researched. A comparison between two configurations with and without outlet guide vanes allows for the formulation of an evaluation criterion of the rotor-only configuration. Utilizing this evaluation criterion, the investigation of velocity profiles corresponding to generic rotor designs shows promise in terms of pressure recovery for new designs.
Effectiveness and Consequences of Direct Access in Physiotherapy: A Systematic Review
Authors: Gallotti Marco , Campagnola Benedetta , Cocchieri Antonello , Mourad Firas , Heick John D. , Maselli Filippo
Published: September 2023

Background. Direct access in physiotherapy (DAPT) occurs when a patient has the ability to self-refer to physical therapy without physician referral. This model of care in musculoskeletal diseases (MSDs) has shown better outcomes than the traditional-based medical model of care that requires physician referral to access physiotherapist services. This traditional physician referral often results in a delay in care. Unfortunately, DAPT is still not permitted in many countries. Objectives. The primary objective of this systematic review was to compare the effectiveness, safety, and the accuracy of DAPT compared to the physician-led model of care for the management of patients with musculoskeletal disorders. The secondary objective of the present study is to define the physiotherapists’ characteristics or qualifications involved in DAPT. Materials and methods. Databases searched included: Medline, Scopus and Web of Science. Databases were searched from their inception to July 2022. Research strings were developed according to the PICO model of clinical questions (patient, intervention, comparison, and outcome). Free terms or synonyms (e.g., physical therapy; primary health care; direct access; musculoskeletal disease; cost-effectiveness) and when possible MeSH (Medical Subject Headings) terms were used and combined with Boolean operators (AND, OR, NOT). Risk of bias assessment was carried out through Version 2 of the Cochrane risk-of-bias tool (ROB-2) for randomized controlled trials (RCTs) and the Newcastle Ottawa Scale (NOS) for observational studies. Authors conducted a qualitative analysis of the results through narrative analysis and narrative synthesis. The narrative analysis was provided for an extraction of the key concepts and common meanings of the different studies, while the summary narrative provided a textual combination of data. In addition, a quantitative analysis was conducted comparing the analysis of the mean and differences between the means. Results. Twenty-eight articles met the inclusion criteria and were analyzed. Results show that DAPT had a high referral accuracy and a reduction in the rate of return visits. The medical model had a higher use of imaging, drugs, and referral to another specialist. DAPT was found to be more cost-effective than the medical model. DAPT resulted in better work-related outcomes and was superior when considering patient satisfaction. There were no adverse events noted in any of the studies. In regard to health outcomes, there was no difference between models. ROB-2 shows an intermediate risk of bias risk for the RCTs with an average of 6/9 points for the NOS scale for observational studies. Conclusion. DAPT is a safe, less expensive, reliable triage and management model of care that results in higher levels of satisfaction for patients compared to the traditional medical model. Prospero Registration Number: CRD42022349261.
Validation of Digital Impressions’ Accuracy Obtained Using Intraoral and Extraoral Scanners: A Systematic Review
Authors: Shah Naisargi , Thakur Mrinmyaee , Gill Shruti , Shetty Omkar , Alqahtani Nasser M. , Al-Qarni Mohammed A. , Alqahtani Saeed M. , Elagib Mohamed Fadul A. , Chaturvedi Saurabh
Published: September 2023

Background: At present, the evidence regarding digital impressions’ accuracy recorded by using digital scanners is lacking. This systematic review aimed to evaluate whether the type of scanning (intraoral/extraoral) affects the Accuracy of Digital Impressions. Method: Two independent reviewers performed a systematic search in the database both electronically and manually (PubMed, Ebsco HOST, the Cochrane Library, and Google Scholar) for articles published from 1 January 2010 to 1 December 2022. This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO CRD42020188765) and followed the PRISMA statement. The question in focus was as follows: Does the type of scanning (intraoral or extraoral) affect the accuracy of digital impression? Results: A total of 449 papers were obtained by searching electronically and manually. In total, 15 complete-text papers qualified for assessment based on eligibility criteria. After reading the full-text articles, five studies were excluded. Ten studies were selected for the qualitative analysis. The qualitative data reported that the accuracy of both types of scanners (intraoral and extraoral) lies within the range of clinical acceptability. Nevertheless, the intraoral scanners seem to be more accurate when compared to the extraoral scanners for a partial arch situation. Conclusions: Scanning type affects the accuracy of the digital impression. Various factors influence the scanning ability. Intraoral scanners seem to be more accurate compared to extraoral scanners for a partial arch situation. More studies comparing the accuracy of the intraoral scanner and extraoral scanner for a complete arch scan and in an in vivo study setting are needed.
Dynamic Hyperinflation While Exercising—A Potential Predictor of Pulmonary Deterioration in Cystic Fibrosis
Authors: Shmueli Einat , Gendler Yulia , Stafler Patrick , Levine Hagit , Steuer Guy , Bar-On Ophir , Blau Hannah , Prais Dario , Mei-Zahav Meir
Published: September 2023

Background: Lung function deterioration in cystic fibrosis (CF) is typically measured by a decline in the forced expiratory volume in one second (FEV1%), which is thought to be a late marker of lung disease. Dynamic hyperinflation (DH) is seen in obstructive lung diseases while exercising. Our aim was to assess whether DH could predict pulmonary deterioration in CF; a secondary measure was the peak VO2. Methods: A retrospective study was conducted of people with CF who performed cardiopulmonary exercise tests (CPETs) during 2012–2018. The tests were classified as those demonstrating DH non-DH. Demographic, genetic, and clinical data until 12.2022 were extracted from patient charts. Results: A total of 33 patients aged 10–61 years performed 41 valid CPETs with valid DH measurements; sixteen (39%) demonstrated DH. At the time of the CPETs, there was no difference in the FEV1% measurements between the DH and non-DH groups (median 83.5% vs. 87.6%, respectively; p = 0.174). The FEV1% trend over 4 years showed a decline in the DH group compared to the non-DH group (p = 0.009). A correlation was found between DH and the lung clearance index (LCI), as well as the FEV1% (r = 0.36 and p = 0.019 and r = −0.55 and p = 0.004, respectively). Intravenous (IV) antibiotic courses during the 4 years after the CPETs were significantly more frequent in the DH group (p = 0.046). The peak VO2 also correlated with the FEV1% and LCI (r = 0.36 and p = 0.02 and r = −0.46 and p = 0.014, respectively) as well as with the IV antibiotic courses (r = −0.46 and p = 0.014). Conclusions: In our cohort, the DH and peak VO2 were both associated with lung function deterioration and more frequent pulmonary exacerbations. DH may serve as a marker to predict pulmonary deterioration in people with CF.
Risk Factors for Post-Stroke Pneumonia in a Patient Population with Subacute Stroke: A Retrospective Cohort Study
Authors: Tashima Hiroyuki , Ito Mari , Kawakami Michiyuki , Ishii Ryota , Miyazaki Yuta , Akimoto Tomonori , Tsujikawa Masahiro , Kobayashi Keigo , Kondo Kunitsugu , Tsuji Tetsuya
Published: September 2023

The risk of pneumonia and death is higher in acute stroke patients with signs of pulmonary infection on chest computed tomography (CT) at admission. However, few reports have examined the incidence of pneumonia and its predictors in subacute stroke patients. The aim of this study was to examine factors related to post-stroke pneumonia in subacute stroke patients. A total of 340 subacute stroke patients were included. Univariable logistic regression analysis was performed using variables that may contribute to pneumonia, with the development of pneumonia as the dependent variable. Multivariable logistic regression analysis using the three independent variables with the lowest p-values on the univariable logistic regression analysis was also performed to calculate adjusted odds ratios. Twenty-two patients developed pneumonia during hospitalization. The univariable logistic regression analysis showed that the top three items were serum albumin (Alb), functional Oral Intake Scale (FOIS) score, and signs of pulmonary infection on chest CT at admission. Multivariable logistic regression analysis adjusted for these three items showed that the presence of signs of pulmonary infection on chest CT at admission was the independent variable (OR: 4.45; 95% CI: 1.54–12.9). When signs of pulmonary infection are seen on admission chest CT, careful follow-up is necessary because pneumonia is significantly more likely to occur during hospitalization.
Safety and Efficacy of Orbital Atherectomy in the All-Comer Population: Mid-Term Results of the Lower Silesian Orbital Atherectomy Registry (LOAR)
Authors: Rola Piotr , Włodarczak Szymon , Barycki Mateusz , Furtan Łukasz , Jastrzębski Artur , Kędzierska Michalina , Doroszko Adrian , Lesiak Maciej , Włodarczak Adrian
Published: September 2023

Background: Coronary calcifications represent a challenging subset for the interventional cardiologist performing percutaneous coronary intervention (PCI) and are well-established risk factors for adverse outcomes. Adequate plaque modification prior to stent implantation is critical to achieve an optimal outcome following PCI. Recently, a novel orbital atherectomy device has been introduced into clinical practice to modify calcified plaques. We evaluated the mid-term safety and efficacy of OA in a high-risk “all-comers” population. Methods: We evaluated 96 consecutive patients with severely calcified coronary lesions who underwent PCI facilitated by the orbital atherectomy device. Results: In-hospital MACCE was 5.2% without target lesion revascularization. At 6-month follow-up, the MACCE rate was 10.4% with a concomitant TLR rate of 1%. Conclusions: Our mid-term data showed good safety and efficacy of orbital atherectomy as a plaque-modifying tool in an all-comers cohort with severely calcified coronary lesions.
Prevalence and Characteristics of Patients Requiring Surgical Reinterventions for Ankle Fractures
Authors: Reyes-Valdés Abraham , Martínez-Ledezma Mirna , Fernández-Quezada David , Guzmán-Esquivel José , Cárdenas-Rojas Martha Irazema
Published: September 2023

(1) Background: Ankle fractures are common injuries that typically require surgical treatment. Complications may arise, leading to reinterventions with poor recovery and reduced quality of life for patients. The aim of this study was to determine the number of patients who underwent surgical reintervention for ankle fractures, characteristics, and associated factors. (2) Methods: A cross-sectional study was conducted to analyze the number of patients requiring surgical intervention for ankle fractures at General Hospital Zone No1 IMSS in Colima over a period of two years. The age, gender, comorbidities, laterality, cause of surgical reintervention, Weber classification, and elapsed time to reintervention were analyzed. (3) Results: A total of 33 patients were included in this study, of whom 63.3% were male, ranging in age from 18 to 51 years old. The predominant Danis–Weber classification for both sexes was suprasyndesmotic fracture (Type C). No established relationship was found between comorbidities and surgical reintervention; however, a significant relationship was observed between home accidents and the need for reintervention. (4) Conclusions: Reintervention in patients previously operated on for ankle fractures is more frequent in male patients and those who sustained the injury at home.
Severe Asthma and Biological Therapies: Now and the Future
Authors: Sardon-Prado Olaia , Diaz-Garcia Carolina , Corcuera-Elosegui Paula , Korta-Murua Javier , Valverde-Molina Jose , Sanchez-Solis Manuel
Published: September 2023

Recognition of phenotypic variability in pediatric asthma allows for a more personalized therapeutic approach. Knowledge of the underlying pathophysiological and molecular mechanisms (endotypes) of corresponding biomarkers and new treatments enables this strategy to progress. Biologic therapies for children with severe asthma are becoming more relevant in this sense. The T2 phenotype is the most prevalent in childhood and adolescence, and non-T2 phenotypes are usually rare. This document aims to review the mechanism of action, efficacy, and potential predictive and monitoring biomarkers of biological drugs, focusing on the pediatric population. The drugs currently available are omalizumab, mepolizumab, benralizumab, dupilumab, and 1ezepelumab, with some differences in administrative approval prescription criteria between the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Previously, we described the characteristics of severe asthma in children and its diagnostic and therapeutic management.
How a Subclinical Unilateral Vestibular Signal Improves Binocular Vision
Authors: Xavier Frédéric , Chouin Emmanuelle , Serin-Brackman Véronique , Séverac Cauquil Alexandra
Published: September 2023

The present study aimed to determine if an infra-liminal asymmetric vestibular signal could account for some of the visual complaints commonly encountered in chronic vestibular patients. We used infra-liminal galvanic vestibular stimulation (GVS) to investigate its potential effects on visuo-oculomotor behavior. A total of 78 healthy volunteers, 34 aged from 20 to 25 years old and 44 aged from 40 to 60 years old, were included in a crossover study to assess the impact of infra-liminal stimulation on convergence, divergence, proximal convergence point, and stereopsis. Under GVS stimulation, a repeated measures ANOVA showed a significant variation in near convergence (p < 0.001), far convergence (p < 0.001), and far divergence (p = 0.052). We also observed an unexpected effect of instantaneous blocking of the retest effect on the far divergence measurement. Further investigations are necessary to establish causal relationships, but GVS could be considered a behavioral modulator in non-pharmacological vestibular therapies.
Influence of Patient Anatomy on Intraoperative Radiation Exposure and Operation Time during Standard EVAR
Authors: Derwich Wojciech , Barb Alexandru , Vogl Thomas , Oikonomou Kyriakos , Gray Daphne
Published: September 2023

Endovascular aortic repair (EVAR) is the primary treatment for abdominal aortic aneurysms (AAAs). To optimise patient safety during the standard EVAR procedure, we aimed to investigate the influence of patient anatomy on intraoperative radiation exposure and surgical time. This retrospective study comprised 90 patients (mean age 73.4 ± 8.2 years; 92.2% male) with an infrarenal aortic aneurysm who underwent a standard EVAR procedure. The relationships between dose area product, operating time, and anatomical conditions were investigated in preoperative computed tomography angiography using open-source software. Logistic regression analysis indicated that only body mass index (BMI) had predictive value for radiation exposure. The accuracy of the model was 98.67%, with an area under the curve of 0.72. The duration of surgery was significantly correlated with an increased BMI (odds ratio (OR) = 1.183; p < 0.05), the tortuosity of AAAs (OR = 1.124; p < 0.05), and the left common iliac artery (OR = 1.028; p < 0.05). Thus, BMI impacts the prediction of intraoperative radiation exposure more significantly than the anatomical characteristics of the infrarenal aorta and iliac arteries, and the duration of surgery significantly correlates with both BMI and the tortuosity of the infrarenal aorta and iliac arteries.
Novel Risks of Unfavorable Corticosteroid Response in Patients with Mild-to-Moderate COVID-19 Identified Using Artificial Intelligence-Assisted Analysis of Chest Radiographs
Authors: Kim Min Hyung , Shin Hyun Joo , Kim Jaewoong , Jo Sunhee , Kim Eun-Kyung , Park Yoon Soo , Kyong Taeyoung
Published: September 2023

The prediction of corticosteroid responses in coronavirus disease 2019 (COVID-19) patients is crucial in clinical practice, and exploring the role of artificial intelligence (AI)-assisted analysis of chest radiographs (CXR) is warranted. This retrospective case–control study involving mild-to-moderate COVID-19 patients treated with corticosteroids was conducted from 4 September 2021, to 30 August 2022. The primary endpoint of the study was corticosteroid responsiveness, defined as the advancement of two or more of the eight-categories-ordinal scale. Serial abnormality scores for consolidation and pleural effusion on CXR were obtained using a commercial AI-based software based on days from the onset of symptoms. Amongst the 258 participants included in the analysis, 147 (57%) were male. Multivariable logistic regression analysis revealed that high pleural effusion score at 6–9 days from onset of symptoms (adjusted odds ratio of (aOR): 1.022, 95% confidence interval (CI): 1.003–1.042, p = 0.020) and consolidation scores up to 9 days from onset of symptoms (0–2 days: aOR: 1.025, 95% CI: 1.006–1.045, p = 0.010; 3–5 days: aOR: 1.03 95% CI: 1.011–1.051, p = 0.002; 6–9 days: aOR; 1.052, 95% CI: 1.015–1.089, p = 0.005) were associated with an unfavorable corticosteroid response. AI-generated scores could help intervene in the use of corticosteroids in COVID-19 patients who would not benefit from them.
Noninvasive Prediction of Sperm Retrieval Using Diffusion Tensor Imaging in Patients with Nonobstructive Azoospermia
Authors: Gao Sikang , Yang Jun , Chen Dong , Min Xiangde , Fan Chanyuan , Zhang Peipei , Wang Qiuxia , Li Zhen , Cai Wei
Published: September 2023

Microdissection testicular sperm extraction (mTESE) is the first-line treatment plan for nonobstructive azoospermia (NOA). However, studies reported that the overall sperm retrieval rate (SRR) was 43% to 63% among men with NOA, implying that nearly half of the patients fail sperm retrieval. This study aimed to evaluate the diagnostic performance of parameters derived from diffusion tensor imaging (DTI) in predicting SRR in patients with NOA. Seventy patients diagnosed with NOA were enrolled and classified into two groups based on the outcome of sperm retrieval during mTESE: success (29 patients) and failure (41 patients). Scrotal magnetic resonance imaging was performed, and the DTI parameters, including mean diffusivity and fractional anisotropy, were analyzed between groups. The results showed that there was a significant difference in mean diffusivity values between the two groups, and the area under the curve for mean diffusivity was calculated as 0.865, with a sensitivity of 72.2% and a specificity of 97.5%. No statistically significant difference was observed in fractional anisotropy values and sex hormone levels between the two groups. This study demonstrated that the mean diffusivity value might serve as a useful noninvasive imaging marker for predicting the SRR of NOA patients undergoing mTESE.
A Machine Learning Perspective to the Investigation of Surface Integrity of Al/SiC/Gr Composite on EDM
Authors: Abbas Adel T. , Sharma Neeraj , Al-Bahkali Essam A. , Sharma Vishal S. , Farooq Irfan , Elkaseer Ahmed
Published: September 2023

Conventional mechanical machining of composite is a challenging task, and thus, electric discharge machining (EDM) was used for the processing of the developed material. The processing of developed composite using different electrodes on EDM generates different surface characteristics. In the current work, the effect of tool material on the surface characteristics, along with other input parameters, is investigated as per the experimental design. The experimental design followed is an RSM-based Box–Behnken design, and the input parameters in the current research are tool material, current, voltage, pulse-off time, and pulse-on time. Three levels of each parameter are selected, and 46 experiments are conducted. The surface roughness (Ra) is investigated for each experimental setting. The machine learning approach is used for the prediction of surface integrity by different techniques, namely Xgboost, random forest, and decision tree. Out of all the techniques, the Xgboost technique shows maximum accuracy as compared to other techniques. The analysis of variance of the predicted solutions is investigated. The empirical model is developed using RSM and is further solved with the help of a teaching learning-based algorithm (TLBO). The SR value predicted after RSM and integrated approach of RSM-ML-TLBO are 2.51 and 2.47 µm corresponding to Ton: 45 µs; Toff: 73 µs; SV:8V; I: 10A; tool: brass and Ton: 47 µs; Toff: 76 µs; SV:8V; I: 10A; tool: brass, respectively. The surface integrity at the optimized setting reveals the presence of microcracks, globules, deposited lumps, and sub-surface formation due to different amounts of discharge energy.
Recent Advances in Combating Bacterial Infections by Using Hybrid Nano-Systems
Authors: Patel Unnati , Hunt Emily C.
Published: September 2023

In recent years, antimicrobial resistance in many human pathogens has become a serious health concern. Since infections with resistant pathogens cannot be treated with traditional antimicrobial drugs, new strategies are necessary to fight bacterial infections. Hybrid nano-systems may provide a solution to this problem, by combining multiple mechanisms for killing bacteria to synergistically increase the effectiveness of the antimicrobial treatment. In this review, we highlight recent advances in the development of hybrid nano-systems for the treatment of bacterial infections. We discuss the use of hybrid nano-systems for combinational therapy, focusing on various triggering mechanisms for drug release and the development of biomimetic nanomaterials. We also examine inherently antimicrobial nano-systems and their uses in preventing infections due to wounds and medical implants. This review summarizes recent advances and provides insight into the future development of antimicrobial treatments using hybrid nanomaterials.