bluuebunny/crossref_metadata_2025 huggingface dataset:
PROTECTION OF INTELLECTUAL PROPERTY RIGHTS: PROBLEMS OF THEORY AND PRACTICE
Authors:   Taras Shevchenko National University of Kyiv, Grynchuk Vladyslav
Published: September 2022

The article examines the peculiarities of the protection of intellectual property rights in the context of the reform of national legislation in the field of intellectual property. It is proposed to consider the protection of intellectual property rights as a mechanism provided for by law, which consists of a system of forms, methods and means initiated by subjects whose rights have been violated and by specially authorized state bodies, whose activities are aimed at recognizing and renewing violated rights, stopping the violation of rights and legitimate interests of subjects of intellectual property rights in the event of their violation, challenge or non-recognition and on the application of state coercion measures to offenders. Currently, in Ukraine, activities related to the protection of intellectual property rights are mostly focused on the actions of the state to establish standards, and almost no attention is paid to the need of the business itself for self-improvement. Following the example of the United States of America, it is advisable for Ukraine to create associations, as a union for many types of businesses related to intellectual property rights, to develop a strategy to combat intellectual property rights violations and control the number of such violations. Despite the positive changes in the laws in the field of intellectual property rights protection carried out in recent years, it should be emphasized the presence of certain shortcomings and contradictions in the legal regulation of the procedure for the protection of rights to inventions, utility models and industrial designs, which, first of all, are caused by the lack of necessary changes regarding the implementation legislative norms to the sub-legal level. It is noted that measures to ensure the effective protection of intellectual property rights should be directed not only by the state and its bodies, the activities of the right holders themselves in monitoring the observance of their rights and preventing violations should play a major role in this process.
LEGAL WRITING: CATEGORIZATION OF THE CONCEPT AND FEATURES OF USE
Authors:   Yuriy Fedkovych Chernivtsi National University, Stratii Oleksii , Shevchuk Andrii ,   Yuriy Fedkovych Chernivtsi National University
Published: September 2022

Article has been devoted to the problems of legal writing in terms of the definitive identification of the content of the outlined category and the interpretation of the features of legal writing. It has been defined that legal writing – is the tool, which is used during the creation of legal documents. Whereas the category «writing» is characterized by polysemy. Firstly, writing – is the process of action due to the meaning of the verb «to write». Secondly, this is an official document. Thirdly, these are also methods of creating literary and artistic works. The proposed interpretation of the term «legal writing» by author is: the text prepared by a lawyer that has a legal content, or half-page business letter, hundred-pages memorandum or legal opinion, draft contract or draft law, procedural paper intended for submission to court, or other document. It has been mentioned that nowadays there are different classifications of types of legal writing. For the purposes of this work, a classification was chosen, in which the criterion for differentiation is, in particular, the target orientation of the document, which determines the tonality of the document and the way the material is presented. That classification is not spread in the Ukrainian legal literature, but it can be used for our legal realities. According to this, the purpose of document can be: analysis of the issue; argument; regulation. The main feature of the analytical legal writing – is neutral analysis of a legal situation or problem. The analytical legal writing contains letters to clients, memoranda, legal opinions, analytical materials, articles in legal journals, monographic works. The second variety – argumentation letter, in which a certain position is being defended, the interests of one of the parties are being protected. It is important to convince the addressee of his/her rightness, or the correctness of the position of the author of the text (or the person, which is presented by the author of the text). The third variety of legal writing, significantly differentiated from previous two from the point of view of legal writing, constitute legal documents (for example, statutory documents of a legal entity), contracts and normative legal acts.
FEATURES OF INTERACTION OF THE MINISTRY OF DEFENSE OF UKRAINE WITH OTHER SUBJECTS OF DEMOCRATIC CIVIL CONTROL OVER THE DEFENSE FORCES
Authors:   Interregional Academy of Personnel Management, Podoliaka Anatolii , Khrystynchenko Nadiia ,   Taras Shevchenko National University of Kyiv, Shopina Iryna ,   Lviv State University of Internal Affairs
Published: September 2022

The purpose of the article is to determine the features of interaction between the Ministry of Defense of Ukraine and other subjects of democratic civilian control over the defense forces. The article establishes circumstances confirming the importance of legal regulation of interaction between the Ministry of Defense of Ukraine and other subjects. The author substantiates that the interaction of the Ministry of Defense of Ukraine with the subjects of democratic civilian control over the Defense Forces is a coordinated activity aimed at obtaining by joint efforts information and data on shortcomings in the functioning of these Forces and developing a model for their optimization in the legal, military, social, economic and other aspects. The features of the interaction of the defense department with other subjects of democratic civilian control are attributed to: a) the leading nature of the communicative function of interaction as a process of transferring data from the communicator (Ministry of Defense of Ukraine) to recipients (legislative, executive and judicial authorities, local governments, the public); b) providing, through interaction, a feedback between the functioning of the Defense Forces and the reflection of such functioning at the legal level through compliance with the principles of the rule of law and intolerance to corruption; c) the use of interaction between the Ministry of Defense of Ukraine and other subjects of democratic civilian control as an effective factor in preventing social conflicts in society caused by the restriction of the free circulation of information under the legal regime of martial law; d) the formation, thanks to the interaction, of an expert environment, whose efforts are aimed at finding optimal ways for the functioning and development of the defense forces in the conditions of a full- scale armed conflict; ґ) creating in the system of interaction between the Ministry of Defense of Ukraine and other subjects of democratic civil control an optimal balance between transparency and compliance with information security requirements.
ENSURING COMPETITIVENESS AND SUSTAINABLE DEVELOPMENT OF THE MANAGEMENT MECHANISMS SYSTEM OF THE HEALTH CARE SPACE OF EDUCATION IN UKRAINE
Authors:   National University of Life and Environmental Sciences of Ukraine, Vdovenko Nataliia , Horiana Larysa ,   International Academy of Culture of Safety, Ecology and Health
Published: September 2022

The article analyzes the level of developing the system of management mechanisms of the health-saving space of education, innovative activity in the economy and society. The factors affecting the country's place in the competitive dynamics of the world hierarchy, the speed of passing through the steps of technological structures to the knowledge society have been established. Attention is focused on aggregated indicators for building a general index of human development from the perspective of a life safety specialist. The following indicators are used to quantitatively represent the three basic dimensions of human development: average life expectancy at birth, longevity index, where aspects of health care play a leading role; the share of literates among the population aged 15 years and older and the total share of education seekers among the population of the corresponding age, indicators of education; adjusted real GDP per person, an indicator of material well-being. The idea of introducing a medium program, which must be implemented and carried out together with the minimum program through the preparation of society for progress, institutionalization for a specific purpose based on the ideas of sustainable development of the system management mechanisms of the health- preserving space of education, is considered. It is proposed to integrate different approaches and views on one integral, complex problem, the introduction of interdisciplinary terminology, the publication of general conclusions will accelerate the opportunity for current and future managers to implement optimal strategies in order to change the vector of instability on the way to sustainable ecologically safe development. It was concluded that the scientific support of the innovative development path of Ukraine from the side of economists, sociologists, ecologists, psychologists, can be carried out under the condition of reforming the system of education and science management mechanisms through the formation of a powerful motivational health care system. The search for optimal opportunities for the transition to an innovative strategy, or a strategy of sustainable, balanced, sustainable ecologically safe, harmonious, health-preserving education space development through the formation of environmental culture and competitiveness, was carried out.
MENGEVALUASI PERDA WAJIB BELAJAR DUA BELAS TAHUN DI KABUPATEN KUDUS DAN PELAKSANAANNYA PADA WARGA SAMIN
Authors: Rosyid Moh
Published: September 2022

Human rights is the right of every one is right education. This paper observes the right of children of Samin community in Kudus especially in the field of education. Samin community is chosen for its uniqueness in maintaining their anchestor’s teaching not to go to formal school, as a way of resistance against the Dutch colonial government, despite the fact that today some of Samin community go to school and obey government regulation. The main focus of this research is the realization Government Regulation Kudus (Perda) to the required learning 12 years. Method of collecting data conducted through literature, interview, and direct observation in the field. The analysis data used is qualitative descriptive. the results of the research are (1) the required learning 12 years for community Samin did not happen, (2) Persuasive approach is important to encourage Samin community to send their children to formal education as stated by Government Regulation (PP) No 48 Year 2008 Article 15 (1), (2), and (3) Government Regulation Kudus (Perda) to the required learning 12 years must be evaluated by Ombudsman Commision.
EVALUASI PROGRAM SUPERVISI DI SDN NO. 29 PONTIANAK KOTA
Authors: Sukmawati Sukmawati
Published: September 2022

Penelitian ini mengangkat judul yaitu Evaluasi Program Supervisi Pendidikan di Sekolah Dasar Negeri No. 29 Pontianak Kota. Adapun tujuan penelitian ini adalah untuk memperoleh informasi tentang pelaksanaan Supervisi Pendidikan melalui formatif-sumatif evaluation model. Dengan menggunakan model evaluasi ini, peneliti akan mengetahui seberapa jauh program supervisi yang dirancang dapat berlangsung, sekaligus mengidentifikasi hambatan. Dengan mengetahui hambatan dan mengetahui hal-hal yang menyebabkan program tidak lancar, pengambilan keputusan secara dini dapat mengadakan perbaikan yang mendukung pencapaian tujuan program supervisi di sekolah. Selanjutnya untuk memperoleh data tersebut peneliti menggunakan metode deskriptif. Teknik pengumpulan data dengan menggunakan panduan wawancara, observasi, dan dokumen-dokumen yang mendukung data penelitian. Setelah data terkumpul akan dianalisis dengan mengacu kepada pendapat Milles Hubermen sebagai berikut: 1. Reduksi Data, 2. Penyajian Data, dan 3. Penarikan Kesimpulan. Hasil penelitian yang dilakukan di SDN No. 29 Pontianak Kota setelah dianalisis dengan menggunakan pendekatan formatif-sumatif evaluasi model, maka dapat disimpulkan bahwa kepala sekolah telah melaksanakan supervisi akademik dengan baik pada waktu semester ganjil, ketika akan melaksanakan supervisi pada semester genap, sekolah mendapat kendala dengan adanya wabah COVID-19, sehingga supervisi tidak dapat dilaksanakan secara maksimal. Saran yang diberikan untuk SDN No. 29 Pontianak Kota yaitu agar supervisi akademik dapat dilaksanakan secara efektif dan efisien, karena dampak dari kegiatan supervisi ini cukup berpengaruh untuk meningkatkan mutu pembelajaran.  Kata Kunci: Evaluasi Program Supervisi, Pendidikan
KEJENUHAN, MENGASIHI DIRI, DAN GENDER DAPATKAH MEMPENGARUHI BELAJAR MANDIRI SISWA DI MASA PANDEMI COVID 19?
Authors: Rachmah Dwi Nur , Rahmiyati Rahmiyati
Published: September 2022

This study aims to find out what factors can affect students' independent learning during the covid 19 pandemic. As is known, the covid 19 pandemic has changed the learning process from conventional to online learning. This ultimately requires students to be able to learn more independently, which means students understand more problems, search for literature and solve problems independently. State Boredome, self Compassion and gender are thought to affect self directed learning students. This study uses a quantitative approach with a sample of 198 students on SMA IT in South Kalimantan. Research data was collected through google form using self directed learning scale, sstate boredome scale and self compassion scale. Data analysis using multiple regression with the results that there are effect of state boredom, self compassion and gender on self directed learning students. However, of the three research variables, it was only self compassion which significantly affected self directed learning students.
BENEFITS OF FLASHCARD MEDIA IN SPEAKING SKILLS OF STUDENTS WITH SPECIFIC LEARNING DIFFICULTIES
Authors: Ramdhani Intan Sari
Published: September 2022

Speaking skills are one of the language skills that must be mastered by students, including elementary school (SD) students. This skill must always be honed, especially by elementary school students who have specific learning difficulties, so that students can play an active role in communicating. Therefore, it is necessary to have good stimulation to improve the speaking skills of elementary school students. Flashcard media can be used as a medium to improve students' speaking skills. The method used in this research is a literature review or literature study. The results of this study indicate that the flashcard medium is practical and effective when used in learning. By utilizing Flash Card media, learning is more conducive and fun because Flashcard media can attract students' attention. Students' mastery of language develops and students' speaking skills, especially those of students with specific learning disabilities, increase. Students are easier to add and pronounce vocabulary and memorize vocabulary, which helps students recognize letters and make it easier for students to be able to tell stories according to what is in the picture, so that students' imaginations develop, helping students to learn to think critically, students' enthusiasm for learning increases, and students become more courageous.
Hirtelen szívhalál, újraélesztés a European Resuscitation Council 2021-es ajánlása tükrében
Authors: Nagy Bettina , Kiss Boldizsár , Pál-Jakab Ádám , Fülöp Gábor Áron , Perge Péter , Straub Éva , Németh Marianna , Kovács Enikő , Merkely Béla , Zima Endre
Published: September 2022

A fejlett országokban a hirtelen szívhalál napjainkban is a vezető kardiovaszkuláris halálokok közé tartozik. Európában gyakorisága évente mintegy 84/100 000 fő. Az elmúlt évtizedekben számos rizikófaktort azonosítottak, amelyeknek ismeretével a prognózis javítható. Írásunkban a kórházon belül (IHCA), illetve a kórházon kívül (OHCA) kialakult hirtelen szívhalál incidenciáját, major prognosztikai faktorait és a túlélést javító lehetséges eszközöket mutatjuk be. Ezentúl összegeztük a 2021-es új irányelveket az alap- és emeltszintű újraélesztési protokollokat illetően.
A kardiális kontraktilitás modulációjával elért bal kamrai reverz remodelling egy dilatatív cardiomyopathiás betegben
Authors: Tóth Anna Zsófia , Csanádi Zoltán , Sándorfi Gábor , Nagy László
Published: September 2022

Dilatatív cardiomyopathia talaján kialakult, súlyosan csökkent balkamra- (BK-) funkcióval (EF: 30%) járó szívelégtelenség miatt kardiáliskontraktilitás-modulátor (CCM) pacemakert implantáltunk egy 65 éves férfinak, keskeny QRS-komplex és optimális gyógyszeres kezelés ellenére perzisztáló NYHA III panaszok mellett. Betegünk esetében a szívkontraktilitás-moduláció reverz remodellinget eredményezett, amit a BK-funkció növekedése (EF: 46%), a BK végszisztolés térfogatának (ESV) >15%-os csökkenése, valamint a funkcionális kapacitás javulása (NYHA I) reprezentált. CCMpacemaker beültetése szóba jöhet optimális gyógyszeres terápia mellett 25-45% közötti EF-jú, NYHA II-III funkcionális stádiumú, iszkémiás, vagy noniszkémiás etiológiájú szívelégtelen betegek számára, ahol a CRT kritériumai nem teljesülnek, vagy CRT nonrespondernek bizonyultak.
AV-nodális reentry tachycardia, mint a pitvarfibrilláció potenciális triggere
Authors: Jánosi Kristóf-Ferenc , Debreceni Dorottya , Simor Tamás , Kupó Péter
Published: September 2022

Pitvarfibrilláció (PF) katéteres úton történő ablációja során a goldstandard eljárás a pulmonalis vénák (PV) cirkuláris izolációja. Az esetek egy részében azonban a ritmuszavar nem PV-eredetű triggerekre vezethető vissza (pl.: Marshall-ligamentum, bal pitvar posterior fal, vagy vena cava superior eredetű triggerek). Az extra-PV-triggerek egy részéért supraventricularis tachycardiák (SVT) tehetők felelőssé. A 35 éves, társbetegségekkel nem rendelkező, strukturálisan ép szívű nőbeteget több alkalommal vizsgálták sürgősségi osztályon recidív PF miatt. Antiaritmiás szerre (AAD) refrakter, panaszokat okozó PF miatt pulmonalis vénaizoláció (PVI) elvégzésének megítélésére referálták klinikánkra. A klinikumot figyelembe véve a tervezett PVI előtt invazív elektrofiziológiai diagnosztikus vizsgálatot végeztünk, amely során konzekvensen reprodukálható AV-nodális reentry tachycardia (AVNRT) jelentkezett, amely két alkalommal is PF-be degenerálódott, majd spontán szűnt. AV-csomó lassúpálya-ablációt végeztünk, a PF-et szekunder ritmuszavarnak tartottuk, ezért a PVI-től eltekintettünk. A 9 hónapos utánkövetés során ritmuszavar-recidíva nem jelentkezett. A klinikai képet holisztikusan tekintve, PF-ben szenvedő betegeknél válogatott esetekben indokolt lehet a PVI előtt invazív elektrofiziológiai vizsgálat elvégzése, egy addig fel nem ismert, dokumentálásra nem került SVT diagnosztizálására, amely a PF triggereként szerepelhet.
Tricuspid regurgitation and right ventricular contraction pattern in heart failure with reduced ejection fraction: a 3D echocardiography study
Authors: Shiida Kai , Ujvári Adrienn , Lakatos Bálint Károly , Tokodi Márton , Kosztin Annamária , Veres Boglárka , Schwertner Walter , Kovács Attila , Fábián Alexandra , Merkely Béla
Published: September 2022

The development of secondary tricuspid regurgitation (TR) is associated with poor outcomes in patients with heart failure and reduced left ventricular (LV) ejection fraction (HFrEF). Data are scarce concerning the right ventricular (RV) morphological and functional remodeling in HFrEF in relation to the severity of TR. Accordingly, we aimed to characterize RV remodeling in HFrEF patients with and without significant TR using three-dimensional (3D) echocardiography. We retrospectively identified 138 patients with HFrEF. In this cohort, we graded TR severity according to current guidelines and compared patients with no to mild TR (non-significant TR, n=78) versus patients with moderate to severe TR (significant TR, n=60). All patients underwent clinically indicated 3D transthoracic echocardiography. 3D LV and RV end-diastolic volumes (EDVi) and ejection fractions (EF) were measured. To characterize RV mechanical pattern, the ReVISION method was used to quantify the contribution of the longitudinal, radial, and anteroposterior motion components to total RV EF. Patients with significant TR had higher LV EDVi and lower LV EF compared with patients with non-significant TR (LV EDVi: 117.2±34.9 vs. 102.6±39.6 ml/m2; LV EF: 27.0±6.6 vs. 30.2±7.7%, both p<0.05). Concerning the right heart, RV EDVi was significantly higher in patients with significant TR compared with those without (92.1±32.4 vs. 74.1±26.9 ml/m2; p<0.01). RV EF was lower in patients with significant TR (36±10.3 vs. 42.5±9.3%, p<0.05). Regarding RV mechanics, anteroposterior and longitudinal components were significantly decreased in patients with significant TR compared with patients with non-significant TR (anteroposterior relative contribution: 10.0±4.5 vs. 11.7±3.7%; longitudinal: 8.2±3.8 vs. 11.1±3.8%; both p<0.05). On the other hand, the radial component did not show a difference between patients with or without significant TR (17.8±6.9 vs. 19.8±6.2%; p=NS). By assessing RV mechanics using 3D echocardiography, we have shown that HFrEF patients with significant TR presented with reduced RV global function, mainly attributable to the deterioration of the longitudinal and anteroposterior motion components. Identification of the turning point where RV plasticity diminishes, and significant TR develops would be of high clinical interest for more tailored therapeutic decisions.
Chloroquin indukálta cardiomyopathia avagy a „pszeudo-Fabry-kór” fatális lefolyású esete
Authors: Ezer Péter , Kálmán Endre , Nógrádi Ágnes , Vértes Vivien , Cziráki Attila , Faludi Réka
Published: September 2022

A chloroquint napjainkban szisztémás autoimmun kórképek kezelésére használják, autoimmun szöveti károsodást gátló és immunomoduláns hatása miatt. Ritka, ám súlyos mellékhatása a szernek, hogy restriktív cardiomyopathia-szerű képet okozhat, ami fenotípus és hisztológiai kép tekintetében egyaránt a Fabry-kór kardiális manifesztációjára emlékeztet. Munkánkban egy 73 éves nőbeteg esetét mutatjuk be, akinek fulmináns lefolyású szívelégtelensége hátterében chloroquin-cardiomyopathia állt. A beteg anamnézisében tartós chloroquinszedés szerepelt, rheumatoid arthritise miatt. 71 éves, korában harmadfokú atrioventricularis blokk miatt igényelt végleges pacemaker-implantációt. 2 évvel később kardiális dekompenzáció miatt került intézeti felvételre. Ekkor transthoracalis echokardiográfia során masszív koncentrikus bal kamrai hipertrófia, közepes fokban csökkent szisztolés balkamra-funkció és restriktív típusú mitrális beáramlási görbe volt észlelhető. A beteg a kéthetes hospitalizáció során kompenzálható volt, azonban 1 hónapon belül súlyos állapotban rehospitalizációra került sor, ami fatális kimenetelű volt. A klinikai kép és az autopsziás lelet alapján felmerült Fabry-betegség gyanúja. Tekintettel azonban a beteg tartós chloroquin szedésére, chloroquin indukálta cardiomyopathiát valószínűsítettünk. A chloroquin kardiális jellegű mellékhatásai – bár az alkalmazási előírásban említésre kerülnek – kevésbé ismertek. Ajánlásokra lenne szükség azzal kapcsolatban, hogy milyen gyakran, milyen módszerrel javasolt a tartósan chloroquint szedő betegek kardiológiai szűrése.
Multi-Stage Condensation Pathway Minimizes Hysteresis in Water Harvesting with Large-Pore Metal-Organic Frameworks
Authors: Zaragoza Alberto , Factorovich Matias , Molinero Valeria
Published: September 2022

Metal-organic frameworks (MOFs) have emerged as promising materials for atmospheric water harvesting (AWH). Large-pore MOFs provide high water capacity, but their significant hysteresis between sorption and desorption makes them unsuitable for AWH. Co2Cl2(BTDD) is a noteworthy exception. This MOF has large, 2.2 nm diameter one-dimensional pores, and combines both record-high water capacity and minimal hysteresis, making it an excellent material for water capture in arid areas. Sorption reversibility in Co2Cl2(BTDD) has been attributed to continuous water uptake. However, the sharp adsorption/desorption in the isotherms supports a discontinuous first-order transition. Here we use molecular simulations to compute the water adsorption and desorption pathways and isotherms in Co2Cl2(BTDD), to elucidate how does this MOF achieve reversibility despite its large pore size. The simulations reveal a multi-stage mecha-nism of discontinuous water uptake facilitated by spatial segregation of rows of hydrophilic metal sites bridged by ~1 nm hydrophobic ligands. The multi-stage mechanism breaks the barrier of capillary condensation into smaller, easier to surmount ones, resulting in a facile process despite the sharp density discontinuity between confined liquid and vapor. We find that water-metal attraction in Co2Cl2(BTDD) is optimal for AWH: stronger ones reduce the water capacity, and weaker attraction results in sharp increase of the hysteresis. A putative chemically homogeneous porous material with same structure and equilibrium pressure of Co2Cl2(BTDD) condenses water through a single-step path-way with extreme hysteresis, demonstrating that thermodynamics and kinetics of water uptake are decoupled. These findings can guide the design of water harvesting materials with maximal capacity and reversibility.
Multi-particle orientational correlations are responsible for the nonlinear dielectric effect: Analysis of temperature-dependent measurements for glycerol
Authors: Matyushov Dmitry
Published: September 2022

The nonlinear dielectric effect (NDE) is traditionally viewed as originating from saturation of the response of individual dipoles in a strong electric field. This mean-field view, mathematically described by the Langevin saturation function, predicts enhanced dielectric saturation at lower temperatures. In contrast, recent experiments for glycerol have shown a sharp increase of the NDE with increasing temperature. The NDE is a sum of a term representing binary correlations of dipolar orientations and terms referring to three- and four-particle orientational correlations. Analysis of experimental data shows that the contribution of three- and four-particle correlations strongly increases at elevated temperatures. The mean-field picture of dielectric saturation as the origin of the NDE is inconsistent with observations. A positive NDE (increment of the field-dependent dielectric constant) is predicted for low-concentration solutions of polar molecules in nonpolar solvents. The dependence of the NDE on the concentration of the polar component is polynomial.
Ion mobility-mass spectrometry and collision induced unfolding of designed bispecific antibody therapeutics
Authors: Villafuerte-Vega Rosendo , Li Henry , Slaney Thomas , Chennamsetty Naresh , Chen Guodong , Tao Li , Ruotolo Brandon
Published: September 2022

Bispecific antibodies (bsAbs) represent a critically important class of emerging therapeutics capable of simultaneously two different antigens simultaneously. As such, bsAbs have been developed as effective treatment agents for diseases that remain challenging for conventional monoclonal antibody (mAb) therapeutics to access. Despite this, bsAbs are intricate molecules, requiring both the appropriate engineering and pairing of linked heavy and light chains derived from separate parent mAbs. Current analytical tools for tracking the bsAb construction process have demonstrated a limited ability to robustly probe the higher order structure (HOS) of bsAbs. Native ion mobility-mass spectrometry (IM-MS) and collision induced unfolding (CIU) have proven to be useful tools in probing the HOS of mAb therapeutics. In this report, we de-scribe a series of comprehensive IM-MS and CIU datasets that reveal HOS details associated with knob-into-hole (KiH) bsAb model system. We find that quantitative analysis of CIU data indicates that global bsAb stability occupies and in-termediate space between the stabilities recorded for its parent mAbs. Furthermore, our CIU data identifies the hole-containing half of the bsAb construct to be least stable, thus driving much of the overall stability of the bsAb. An analysis of both intact bsAb and enzymatic fragments allows us to link the first and second CIU transitions observed for intact bsAbs to the Fab and Fc domains, respectively. This result is likely general for CIU data collected from low charge state mAb ions and is supported by data acquired for deglycosylated bsAb and mAb constructs, each of which of which indi-cate greater destabilization of the second CIU transition observed in our data. When integrated, our CIU analysis allows us to link changes in the first CIU transition primarily to the Fab region of the hole-containing halfmer, while the second CIU transition is likely strongly connected to the Fc region of the knob-containing half of the bsAb construct. Taken together, our results provide an unprecedented roadmap for evaluating the domain-level stabilities and HOS of both bsAbs and mAb constructs using CIU.
Microfluidic quantum sensing platform for lab-on-a-chip applications
Authors: Allert Robin Derek , Bruckmaier Fleming , Neuling Nick Ruben , Freire-Moschovitis Fabian Alexander , Liu Kristina Song , Schrepel Claudia , Schätzle Philip , Knittel Peter , Hermans Martin , Bucher Dominik Benjamin
Published: September 2022

Lab-on-a-chip (LOC) applications have emerged as an invaluable tools in physical and life sciences. However, LOC applications require extensive sensor miniaturization to leverage their full potential. In recent years, novel atom-sized quantum sensors have enabled measurements of temperature, electric and magnetic fields on the nano- to microscale. Nevertheless, the technical complexity of both disciplines has so far impeded an uncompromising combination of LOC and quantum sensors. Here, we present a fully integrated microfluidic platform for solid-state spin quantum sensors, such as the nitrogen-vacancy (NV) center in diamond. Our platform fulfills all technical requirements, such as fast spin manipulation, enabling full quantum sensing capabilities, biocompatibility, and easy adaptability to arbitrary channel and chip geometries. To illustrate the vast potential of quantum sensors in LOC devices, we demonstrate various NV center-based magnetic resonance experiments for chemical analysis in our microfluidic platform. We anticipate our microfluidic quantum sensing platform as a novel tool for electrochemistry, high throughput reaction screening, bioanalytics or organ-on-a-chip, and single-cell studies.
Effects of acute β-alanine supplementation on countermovement jump performance after a 4x400 m running fatigue protocol
Authors: Todorovic Nikola , Santibañez-Gutierrez Asier , Milovanov Djordje , Stajer Valdemar , Ostojic Sergej M. , Fernández-Landa Julen
Published: September 2022

This study aimed to examine the effect of acute beta-alanine (β-alanine) supplementation on jump performance after a strenuous fatigue protocol. Twelve healthy young men (age 21.4±0.5 years, body height 180.2±5.8 cm, body mass 76.6±9.2 kg) volunteered to participate in this randomized, double-blind, placebo-controlled trial. The experimental group ingested 3.2 g of β-alanine (separated into two 1.6 g dosages) mixed with 23 g of glucose, whereas the placebo group ingested two dosages containing 23 g of glucose. Following the supplementation intake, participants completed a jump protocol involving countermovement jump (CMJ) and four consecutive countermovement jumps (CMJ-4). Subsequently, a 4x400 m running fatigue protocol was carried out to produce fatigue. After the fatigue protocol, the same jumping tests were repeated, CMJ and CMJ-4, to evaluate the loss in jump height. The Mann-Whitney U test was used to analyze differences between the groups, whereas Wilcoxon signed-rank test was conducted to analyze differences within the groups with statistical significance set at p<.05. After β-alanine supplementation, no significant decrease was found in the experimental group in none of the tests after the fatigue protocol. Conversely, a significant decrease was noticed in the placebo group in CMJ but not in the CMJ-4 test. In conclusion, an acute β-alanine supplementation could attenuate jump height loss after the fatigue protocol. Therefore, athletes and coaches should consider acute β-alanine supplementation to attenuate sports performance decrease after high-intensity exercises in which muscle acidosis is highly increased.
Identification of the
optimal hiit protocol for fatigue resistance in adolescent athletes
Authors: Seo Myong-Won , Lee Jung-Min , Jung Hyun Chul , Kim Joon Young , Song Jong Koon
Published: September 2022

The combat sports athletes developed great gains in both muscular function and fatigue resistance by utilizing high-intensity interval training (HIIT). However, it has not fully investigated whether the different work-to-rest ratios of HIIT show the effectiveness on muscle function in adolescent athletes. The purpose of the study was to compare different work-to-rest ratios by applying different rest times in response to the identical work time during HIIT on muscle function in adolescent Taekwondo athletes. Forty-seven adolescent male Taekwondo athletes (age: 16.7±0.8 years) were randomly assigned to the control group (n=11) vs. three HIIT groups by work-to-rest ratios; 1) 1:2 [30s:60s] (n=12), 2) 1:4 [30s:120s] (n=12), and 3) 1:8 [30s:240s] (n=12). All groups completed 10 experimental sessions over four weeks, while the control group maintained their regular Taekwondo training. Muscular functions were measured by assessing isokinetic muscle strength and endurance of the knee extensor and flexor. The participants performed three sets of twenty maximal extension and flexion contractions at 120°s-1 with a 1-min interval between the sets for fatigue resistance. Blood samples were collected to measure free-testosterone, cortisol, creatine kinase, and urea as stress-to-recovery indicators. A positive effect on improving muscle fatigue resistance was observed at the first set of assessments in the HIIT with 1:4 (Δ10.2%, p<.05) and 1:8 groups (Δ8.6%, p<.05). Additionally, the 1:4 group exhibited fatigue improvement in the second set (Δ7.7%, p<.01) without any changes of stress-to-recovery indicators, while the other groups did not show any improvement. The 30s all-out with 120s rest time, lasting over a brief 4-week period, improved their fatigue resistance. A certain amount of rest time between high-intense movements is required to optimize muscle development in adolescent athletes compared with insufficient rest time.
Influence of cupping treatment on high-intensity anaerobic performance
Authors: Al-Horani Ramzi A. , Alsays Khaled M. , Ihsan Mohammed
Published: September 2022

The use of cupping therapy prior to sports events has increased in popularity, with limited evidence to support its efficacy. The purpose of this study was to evaluate the efficacy of dry and wet cupping therapy on subsequent Wingate anaerobic test (WAnT) performance. Twelve trained men participated in this repeated-measures randomized crossover study (age 24.9 ± 4.8 years; body mass index 27.6 ± 14.3 kg.m-2). Participants were familiarized with the ergometer and the Wingate anaerobic test on three separate occasions. They then randomly performed three experimental Wingate tests separated by 48-72 h after either dry cupping (DRY), wet cupping (WET), or no treatment (CON). Repeated measures ANOVA and Pearson’s correlation coefficient were used to analyze data and determine the relationships between WAnT and peak lactate and heart rate (HR). Peak power (PP), mean power (MP), and fatigue index (FI) were similar in all treatments (p=.47-.72). Heart rate (HR) and lactate increased similarly at all time points in all treatments (p<.001 for all comparisons). Post-WAnT peak HR was moderately, negatively correlated with PP in all treatments and MP in CON only (p<.05 for all correlations). No other significant correlations were detected. The present findings demonstrate no beneficial effects of wet and dry cupping therapy, and hence do not support its use prior to high-intensity anaerobic sports events.
Analysis of physical activity as a mediator between non-ergonomic position of upper body segments and musculoskeletal health in bus drivers
Authors: Mavrin Jeličić Martina , Milošević Milan , Prlenda Nikola
Published: September 2022

The number of injuries and accidents at the workplace are constantly rising, and the most pronounced injuries are related to the musculoskeletal health. Numerous studies have revealed that city bus drivers have a high incidence of musculoskeletal pain. The aim of this study was to determine whether physical activity levels might be a mediator between the non-ergonomic position of the body’s upper segments and musculoskeletal health in professional bus drivers. The study protocol included the assessment of participants’ musculoskeletal health using the Örebro Musculoskeletal Pain Questionnaire, assessment of the non-ergonomic position of the upper body segments when seated by means of the Rapid Upper Limb Assessment, and measuring of the level of physical activity using the Yamax 200 pedometer. The sample consisted of 115 bus drivers, from 40 to 55 years of age, with a minimum work service of 15 years. The relationships among variables were tested using the Spearman correlation coefficient and the Wilcoxon rank sum test to include the selected variables in the multivariate linear regression model. The Box-Cox test indicated the need for logarithmic transformation of the ÖMPQ results used to measure musculoskeletal health, so that a log-linear model was used in the regression analysis. The normality of the distribution of the residual regression models was tested by the Shapiro-Wilk test The main findings of this study indicate that 95.6% of participants reported the presence of musculoskeletal pain and in 24.4% of them a very high risk of the musculoskeletal disorder was observed, which indicated the need for urgent changes. The average number of steps per day was 5,090.8. The physical activity proved (obtained by regression analysis) as a mediator between the non-ergonomic position of the upper body segments and musculoskeletal health (p=.027). The obtained data may serve as an important argument for designing future public health and kinesiology interventions for the improvement of the health of professional bus drivers.
Organizational Culture, Communication, and Job Satisfaction on Employee Performance in the Regional Disaster Management Agency
Authors: Purwanto Arsenius , Bachri Alim , Arifin Zainal
Published: September 2022

This study aims to analyze the influence of organizational culture, communication, and job satisfaction on employee performance. This type of research was explanatory research, to test the relationship between several variables through testing several hypotheses. The sample population in this study were 54 employees who work in regional disaster management agencies in North Barito Regency, Central Kalimantan Province by distributing questionnaires and then processing using multiple regression analysis. The results showed that organizational culture, communication, and job satisfaction partially and simultaneously had a significant effect on employee performance within the Regional Disaster Management Agency of North Barito Regency.
Evaluation of Group-Based Family Income Improvement Program Using Context, Input, Process, Product (CIPP) Evaluation Model
Authors: Damayanti Reny , Yandi Gustava , Fahrianta Riswan Yudhi , Arifin Zainal
Published: September 2022

This study aims to determine the implementation of the UPPKA program using the CIPP evaluation model. This research was evaluative research using a qualitative descriptive approach. Data collection techniques were carried out using observation, interviews, and documentation. Data analysis was done by reducing the data, presenting the data, and drawing conclusions. The triangulation used a source and method to compare the opinions of interested parties on a group-based family income increase program in Pulang Pisau Regency, Central Kalimantan Province. The results showed that (1) the context evaluation was not good, because there was no legal basis, namely the Regent's Regulation even though the implementation of the UPPKA program and training, the suitability of the needs analysis, the suitability of the background and the objectives of the UPPKA program were in accordance with the expected competencies; (2) evaluation of input was not good because the organizers in this case were related agencies that had not yet matured in the context of planning, even though the family planning instructor/instructor was competent and masters the material, UPPKA members were in accordance with the criteria and procedures, the facilities and infrastructure were supported; (3) the evaluation process was not good because the suitability of the activity schedule was uncertain, the performance of the organizers had not been maximized due to planning constraints that affect the implementation of activities even though the family planning instructor was optimal, UPPKA members were still passive, and the evaluation was carried out thoroughly, both evaluation of members, instructors/KB instructors and organizers, where only family planning instructors/extension workers work optimally. Product evaluation was not good because UPPKA members had not mastered the context of administration and management.
The Role of the School Committee in the Implementation of School-Based Management in the Sidoarjo District
Authors: Dewi Nuning Nurna , Rodli Achmad Fathoni , Niswatin Niswatin , Suwanto Insan
Published: September 2022

The role of school committees in improving the quality of education through the concept of School-Based Management (SBM) is motivated by changes in education policy from centralization to decentralization as a consequence of regional autonomy policies. This change has a positive impact, namely encouraging community participation to participate in improving the quality of education. The purpose of this study was to analyze the role of school committees in the implementation of School-Based Management (SBM) policies. Data were collected through document studies and interviews of public and private SMP/MTs in Sidoarjo Regency with a sample of 24 schools, while data analysis was carried out descriptively. The results showed that the role of the school committee was quite high. The advisory role averaged 86%, the supporting role reached an average of 90%, the controlling role averaged 53%, and the mediating role reached an average of 83%. From this percentage, it is hoped that the role of the school committee will have an impact on improving the quality of education continuously.
The Psychic Activities of the Main Characters in the Novel Tempat Paling Sunyi by Arafat Nur
Authors: Yanti Lili , Herniaty Nelly , Dewi Rahmatika , Susanto Heru , Wirawan Gunta , Kamaruddin Kamaruddin
Published: September 2022

This study aims to describe the psychic activity of the main character in Arafat Nur's novel Tempat Paling Sunyi which includes cognitive symptoms, affective symptoms, and conative symptoms. This research method was a descriptive method with a qualitative research form. This study used a literary psychology approach. The source of the data for this research was the novel Tempat Paling Sunyi by Arafat Nur (2015). The data in this study were in the form of quotations (words, phrases, and sentences). Data collection techniques used direct techniques, namely documentary techniques with data collection tools, namely the researchers themselves as key instruments and data recording cards. The data analysis technique used descriptive text analysis techniques. Checking the validity of the data was done by peer checking techniques through discussion and triangulation. Based on the analysis of Arafat Nur's novel of Tempat Paling Sunyi, it can be concluded that the cognitive symptoms in the novel of Tempat Paling Sunyi are attention, observation, response, fantasy, thought, memory, intuition; affective symptoms in the novel of Tempat Paling Sunyi are feelings, affect and stemming, moods; conative symptoms in the novel of Tempat Paling Sunyi are automatism, reflex, instinct, lust, desire, desire.
The Effect of Group Guidance Services to Improve Self-Leadership on the Student Council Administrators
Authors: Fitriyadi Slamat , Mayasari Dian , Syahroni Ahmad , Moseki Usina Robert , Soeprapto Wasis
Published: September 2022

This study aims to: (1) Describe the level of students council administrators’ understanding of self-leadership and its application before being given the services. (2) Knowing how much the Group Guidance service influence to improve the student self-leadership in SMA N 1 Singkawang. The research used is quantitative research, with a one-group pretest-posttest design. The population in this study was all the students of council management of SMA N 1 Singkawang, they were 30 students. The study sample was taken purposively with the number of research samples of 9 students. The data collection techniques used in this study were questionnaires, interviews, and documentation, while the data collection instrument in this study used questionnaire guidelines, interview guidelines and documentation in the form of photos of activities. The data analysis technique used Quantitative Percentage Description and Wilcoxon Matched Pairs test analysis. From the results of the percentage description, the results of 3 students were obtained in the high category, 15 students were in the medium category, 8 students were in the less category and 4 students were in a low category. The data were analyzed using the SPSS.25 application. Based on the testing result, it is known that Asymp. Sig. (2-tailed) is worth 0.008. Because the value of 0.008 is smaller than 0.05 (0.008 < 0.05) it can be concluded that H1 is accepted or there is an influence of group guidance services on the self-leadership of the student council management in SMAN 1 Singkawang.
Potential Effects of ESG (Environmental, Social, and Governance) Policies on the Returns of an Investment Portfolio
Authors: Klimova M.
Published: September 2022

The objective of this work is the corporate ESG policies as they relate to the company’s financial and the consequent stock performance. The subject of the work is the effects of such policies on stock returns and stock portfolio performance. In order, to tackle the problem, the author taken several steps, namely: 

Study of history and underlying principles of the ESG policies

Gathered information concerning common investor approaches to the adoption of the ESG mandates to their investment strategies

Tracked the performance of the broader market indices that follow ESG mandates

Considered particular example of the financial performance of an ESG adhering company

Developed recommendations relating to the appropriate selection of positions to the portfolio with ESG mandate

Overview of the findings and the recommendations for portfolio construction using the ESG principals as a selection criteria are presented in conclusion.