bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PEMBERIAN KONSENTRASI PUPUK ORGANIK CAIR (POC) TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN KUBIS (Brassica oleracea L.)
Authors: Umar Imran , Haris Abdul , S. Gani Mahir
Published: June 2024

Effect of Organic Fertilizer Concentrations Liquid (POC) on the Growth and Production of Cabbage Plants (Brassica olereacea L.) Supervised by Abdul Haris and Mahir S. Gani. The research aimed to measure the effect of liquid organic fertilizer (POC) concentration on the growth and production of cabbage (Brassica oleracea L.). The research was conducted on land owned by farmers in Buluballea hamlet, Pattapang Village, Tinggimoncong District, Gowa Regency, South Sulawesi Province. the study took place from November to January 2020. This research was conducted in an experimental form based on a randomized block design (RAK), which consisted of three concentrations, namely: P1 at a concentration of 1.75 ltr / 15 ltr air, P2 at a concentration of 2.00 ltr / 15 ltr air, P3 at a concentration 2.25 liter / 15 liter of water in each treatment was repeated 3 times so that the experimental unit was obtained and each replication in each treatment consisted of 56 plants, taken as many as 36 samples, so that all plants in the three replications were 504 plants and 324 plants sampled. The results of this study indicate that concentrations of 2.00 ltr / 15 ltr of air and 2.25 ltr / 15 ltr of air have the best effect on the average height of leaf dimeter head and weight of fresh plants. Based on the research that has been done, it can be done to show that the concentration of 2.00 liter / 15 liter of water and 2.25 liter / 15 liter of water is the best response. Moreover, to determine the need for liquid organic fertilizer concentration with a higher concentration which will result in optimal concentration of growth and production of cabbage.
APLIKASI BERBAGAI KONSENTRASI PUPUK ORGANIK CAIR SEBAGAI NUTRISI HIDROPONIK SISTEM SUMBU TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN SELADA (Lactuva sativa L.)
Authors: Bachtiar Muhammad Hamdi , Tjoneng Amir , Aminah Aminah
Published: June 2024

Lettuce is a horticultural commodity that has good prospects and commercial value. One method that can be used in lettuce cultivation is a hydroponic system. The hydroponic system uses complete nutrients as plant fertilizer. In general, hydroponic systems use synthetic fertilizers in the form of AB Mix. However, the use of environmentally friendly organic fertilizers is considered necessary in a hydroponic system. This study aims to determine the application of various concentrations of liquid organic fertilizer as a hydroponic axis system to the growth and production of lettuce plants, to determine the most effective concentration of liquid organic fertilizer in increasing the growth and production of lettuce. This study was conducted at the Green House MR. Farms. This study used a Completely Randomized Design (CRD) consisting of four treatments, namely the provision of Liquid Organic Fertilizer (POC) 15 ml/liter of water, 18 ml/liter of water, 20 ml/liter of water and 22 ml/liter of water. The results of this study indicate that the application of liquid organic fertilizer has a significant effect on the parameters of plant height, number of plant leaves and plant wet weight. However, it did not significantly affect the parameters of leaf width and root length. The most effective concentration of liquid organic fertilizer in increasing lettuce growth and production was the concentration of 22 ml/liter of water.
PENGARUH KONSENTRASI PUPUK DAUN TERHADAP PERTUMBUHAN TANAMAN HIAS AGLAONEMA LIPSTIK (Aglaonema crispum)
Authors: Aulia Putri , Subaedah St , Ralle Andi
Published: June 2024

This study aims to determine the effect of various concentration of Grow More fertilizer on the growth of ornamental plants Aglaonema Lipstick. This research was conducted in Sidorejo Village, Wonomulyo District, Polewali Mandar Regency, West Sulawesi Province, from January to April 2021. This study was arranged based on a randomized block design with 5 treatment fertilizer (control) with a concentration of 1 g/l air, a concentration of 2 g/l air, a concentration of 3 g/l air and a concentration of 4 g/l air. Data were analized by analysis of variance. If there is a significant effect then further tested with the BNJ test. Parameters observed in this study were increase in plant of leaves, leaf length, leaf width, root volume and root length. The results showed that giving Grow More with a concentration of 2 g/l air of water had a good effect on increasing plant height, nomely 5,11 cm, increasing the number of leaves, nomely 4,56 strands, leaf length being 11,20 cm, leaf width being 7,74, root volume is 14,33 cm and root length is 16,00 cm.
PENGARUH WAKTU TANAM YANG BERBEDA TERHADAP PERTUMBUHAN DAN PRODUKSI TERUNG HIJAU (Solanum molagena L.) YANG DITUMPANGSARIKAN DENGAN SAWI HIJAU (Brassica juncea L.)
Authors: Musliadi Musliadi , Haris Abdul , Ralle Andi
Published: June 2024

This study aims to determine the best planting time for eggplant and mustard greens and to determine the Land Equivalence Ratio (NKL) between eggplant and mustard plants intercropped. This research was conducted in Sanresengade Village, Bola District, Wajo Regency, South Sulawesi Province. This research took place from March to June 2021. The study used a randomized block design consisting of 6 levels of treatment at planting time, namely green eggplant and mustard greens planted together, mustard greens planted after 1 week of eggplant planted, green mustard plants planted after 2 weeks eggplant was planted, mustard greens were planted after 3 weeks of eggplant planted, eggplant monoculture, mustard greens monoculture and each treatment was repeated three times so that 18 experimental units were obtained. The results showed that the time of planting eggplant together with mustard greens gave the best effect on eggplant plant growth which was shown to be 69.33 cm high, 22.33 leaves number, 4.08 fruit number, and fruit weight 227.33 g. The time of planting mustard 1 week after eggplant was planted gave the best effect on the growth of the mustard plant which was shown to be 27.50 cm tall, 9.33 leaves and weighed 731.67 g. Green mustard planted 1 week after eggplant was plant produced the highest NKL value of 2.52 so it was feasible to do so.
PENGARUH KONSENTRASI BAWANG PUTIH SEBAGAI PENGAWET ALAMI TERHADAP UMUR SIMPAN DAN MUTU CABAI MERAH BESAR (Capsicum annuum L.)
Authors: Sudirman Nursyamsi , Sabahannur St. , Alimuddin Suraedah
Published: June 2024

This study aims to determine the effect of concentration of garlic as a natural preservative on the shelf life and quality of large red chili (Capsicum annuum L). This research was conducted at the Post-Harvest Laboratory, Faculty of Agriculture, Indonesian Muslim University, Makassar. Using a completely randomized design (CRD) consisting of 5 treatments, namely a concentration of 0% (without garlic, only with distilled water) with a concentration of 25% (75 grams of garlic). 50% concentration (150 grams of garlic), 75% concentration (150 grams of garlic), 100% concentration (300 grams of garlic) in 300 ml of distilled water. The results of this study indicate that large red chilies with garlic have a significant effect on parameters, weight loss, color, texture, and shelf life. Large red chilies soaked in garlic with a concentration of 100% (300 grams/ 300 ml of distilled water) resulted in the lowest weight loss with a value of 46.56%, color with a score of 5.17%, and texture 4.3% with a shelf life of 21 days. And the damage to big red chilies was caused by the fungus Colletotrichum sp. Giving garlic with a concentration of 100% (300 grams of garlic/300 ml of distilled water) can extend and maintain the quality of big red chilies for 21 days.
PERFORMAN PERTUMBUHAN SETEK JERUK NIPIS (Citrus aurantifolia L.) PADA BERBAGAI SUMBER PENGATUR TUMBUH DAN MEDIA TANAM
Authors: Ani Anti , Abdullah Abdullah , Syam Netty
Published: June 2024

This study aimed to determine the effect of various types of growth regulators (natural and synthetic) and growing medium on the growth of lime cuttings. This research was conducted in used a randomized block design. The treatment design consisted of two factors, namely growth regulators and planting medium. Each treatment was repeated 3 times and each experiment used 5 lime cuttings. Data were analyzed using F test and  Tukey test. Parameters observed were budding time, shoot height, number of shoots, number of leaves, number of roots and root length. The results showed that the use of 150 ppm Rootone-F had a very significant effect on the number of shoots (2.29), leaves (16.50), roots (3.37) and root length (5.48 cm). And the use of top soil + burnt husk as planting medium had a significant effect only on the shoot height (7.06 cm).
PENGARUH KONSENTRASI DAN INTERVAL WAKTU PEMBERIAN PUPUK ORGANIK CAIR (POC) NASA TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN TERONG (Solanum melongena L.)
Authors: Dahlan Fia Islamiah , Suriyanti Suriyanti , Ralle Andi
Published: June 2024

This study aims to determine the interaction between concentration and time interval of liquid organic fertilizer application, to determine the best concentration of liquid organic fertilizer, to determine the best time interval of application of liquid organic fertilizer to growth and yield of eggplant. This research was conducted in Sudiang Raya Village, Biringkanaya District, Makassar City, South Sulawesi, from November 2021 to March 2022. This study was arranged using a factorial randomized block design (RAK) with 2 treatment factors. Parameters observed were plant height, number of leaves, age of flowering, number of flowers, number of fruits, fruit length, fruit diameter and fruit weight. The results showed that there was the best interaction between concentration and time interval of Nasa liquid organic fertilizer application on the parameters of plant height, number of leaves and age of flowering. The application of Nasa liquid organic fertilizer with a concentration of 22.55 ml/L water gave the best effect on plant height parameters, namely 19.90 cm, number of leaves was 9.98 strands, flowering age was 32.27 DAP, number of flowers was 2.93 flowers , fruit length is 23.30 cm, fruit diameter is 4.07 cm and fruit weight is 69.62 grams. Then the time interval of giving liquid organic fertilizer 1 time/week gave the best effect on plant height parameters, namely 19.69 cm, flowering age 32.62, number of flowers 2.40 flowers, fruit length 23.27 cm, fruit diameter 3.76 cm and the weight of the fruit is 64.18 grams
UJI ADAPTASI HASIL RADIASI MUTAN VARIETAS PADI LOKAL M6 ASE LAPANG DI AREAL SAWAH KABUPATEN BONE
Authors: Amir Andi Nur Aini , Haris Abdul , Numba Sudirman
Published: June 2024

His research was conducted in Parippung Village. Barebbo District, Bone Regency, South Sulawesi Province. The time of preparation and implementation of this research was carried out from January to May 2022. This study aimed to determine the intensity of gamma ray irradiation in local Ase Lapang rice in environmental adaptation in Bone district. This research approach uses an experimental method with a Randomized Block Design (RAK) pattern, the form of treatment is a field adaptation test to seeds that have been irradiated with 3 treatments with a level of R1 = 100 Gray; R2 = 200 Gray; R3 = 300 Gray, each treatment was grouped into three groups as replicates so that 9 experimental units were obtained. The results showed that radiation doses of plants ranging from 100 garay, 200 gray, and 300 gray could grow and produce well in the Bone Regency area, Ase Lapang local rice gave a better effect on the direction of growth and agronomic characters of plants, namely flowering age, panicle length. , harvest age, grain weight both per clump and per plot and per hectare.
Alkali Treatment on Hybrid Pineapple Leaf and Glass Fibre Reinforced Epoxy Composites
Authors: Syed Pauzi Syed Mohd Ridzuan , Suhaimi Syahida
Published: June 2024

In this paper, the Pineapple Leaf fibre (PALF) have been previously treated with various Sodium Hydroxide (NaOH) concentration percentages in the range between 0% to 10% at 1hour Sodium Hydroxide (NaOH) solution immersion time and dried in oven at 80°C for 24 hours. The influence of Sodium Hydroxide (NaOH) treatment on Pineapple Leaf fibre (PALF) tensile properties was studied. The result of tensile test on PALF treated showed an improvement in tensile strength with highest value of 43.13MPa of treated Pineapple Leaf fibre (PALF), particularly the treated PALF with 7% Sodium Hydroxide (NaOH) concentration. The 7% treated Pineapple Leaf fibre (PALF) was then selected to use as raw materials for hybrid composites with glass reinforced epoxy matrix. The hybrid composites were subjected to distilled water immersion to study moisture absorption behavior on hybrid composites with four different layer sequences named 4P, PGGP, GPPG and PGPG. The pure Pineapple Leaf fibre (PALF) (4P) have recorded highest percentage for both moisture uptake as well as thickness swelling as compared to the other hybrid composites with value of 12.16% and 51.30% respectively. Hybrid composites are the candidate to be used a pressure vessel especially in oil gas and marine industry that deal with wet and dry environment.
مدى تطبيق التنمية المستدامة لعمداء كليات التربية البدنية وعلوم الرياضة من وجهة نظر اعضاء الهيئات التدريسية في بابل والكوفة والقادسية
Authors: Asst. Lec. Alaa Arian Hassan  , Asst. Prof. Dr. Mudar Abdel Baqi Salem  , Asst. Prof. Dr. Sanaa Jabbar Cata
Published: June 2024

هدف البحث الى معرفة مدى تطبيق التنمية المستدامة لكليات التربية البدنية وعلوم الرياضة في (بابل، الكوفة، القادسية) من وجهة نظر اعضاء الهيئات التدريسية. حيث كان المجال البشري يتكون من اعضاء الهيئات التدريسية في كليات التربية البدنيـة وعلوم الرياضة في بابل والكوفة والقادسية. وقد تم تطبيق البحث للمدة من 22/10/2023 لغايـة 22/12/2023. في كليــــــات التربيــــــة البدنيـــــة (بابل. الكوفة. القادسية). وقد استنتج الباحثون ان هنالك تفويض بشكل صحيح لبعض الصلاحيات الممنوحة من قبل القيادات الاكاديمية لرؤساء الاقسام في الكلية يساعد على تسهيل عمل الإجراءات بشكل صحيح     وهنالك مبادأة وإبداع وظيفي في التنمية المستدامة تلعب دورًا حاسمًا من قبل اصحاب القرار في كليات التربية البدنية وعلوم الرياضة تساعد في التولي على قيادة الكلية بالاتجاه الصحيح والتحول الاستراتيجي  بين اعضاء الهيئات التدريسية  واوصى الباحثون ضرورة تعزيز الدور القيادي لأصحاب القرار في كليات التربية البدنية وعلوم الرياضة من خلال عمل معايشة مع كليات عالمية لها تصنيف عالمي متميز في مستوى التعليم العالي وضرورة اشراك اعضاء الهيئات التدريسية في اتخاذ القرار وخاصة عند وقوع الازمات وعمل دورات وورش عمل عن اهمية الاساليب القيادية التحفيزية في اثارة اعضاء الهيئات التدريسية .
Farklı Tahıl- Baklagil Karışım Oranlarının Yem Verim ve Kalitesi Üzerine Etkilerinin Sürdürülebilir Tarım Uygulamaları Açısından Değerlendirilmesi
Authors: Genç Lermi Ayşe , Yıldırım Gülcan
Published: June 2024

Tek yıllık baklagil yem bitkileri sürdürülebilir tarım uygulamalarında önemli bir yer tutmaktadır. Bu araştırma ile Yulaf (Avena sativa L.), arpa (Hordeum vulgare L), yaygın fiğ (Vicia sativa L.), macar fiği (Vicia pannonica L.) bitkilerinin yalın, 40:60 ve 60:40 karışım oranlarında kuru ot verimi, baklagil, buğdaygil ve yabancı ot oranları, ham protein oranı ve ham protein verim değerleri belirlenmiştir. Ekim ve hasat karışım oranının değişimi bakımından yulafın dahil olduğu 60:40 karışım uygulamasında fiğlerin baskın hale geldiği belirlenmiştir. Yaygın fiğ içeren yulaf ve arpa karışım uygulamalarında yabancı ot gelişimini önemli oranda azalttığı tespit edilmiştir. Kuru madde verimi ve ham protein verimi bakımından en yüksek değerler yulaf yaygın fiğ karışım uygulamalarından elde edilmiştir. Bartın ili ve benzer ekolojiler için kuru madde verimi, ham protein verimi ve yabancı ot gelişiminin baskılanması göz önüne alındığında 40:60 oranında yulaf: yaygın fiğ karışım oranı önerilmektedir.
Kiểm định các yếu tố toàn cầu hoá kinh tế tác động đến xuất khẩu tại một số quốc gia Đông Nam Á
Authors: Nguyễn Quang Minh
Published: June 2024

Toàn cầu hóa đang là xu hướng tất yếu, đồng thời xuất khẩu luôn là mục tiêu ưu tiên của nhiều quốc gia. Nghiên cứu xem xét tác động của toàn cầu hóa kinh tế tới yếu tố xuất khẩu, từ đó khuyến nghị các định hướng và chính sách. Bài báo xem xét các quốc gia tiêu biểu tại Đông Nam Á như Việt Nam, Thái Lan, Singapore, Indonesia, Philippines, với dữ liệu được thu thập theo năm từ 5 quốc gia giai đoạn 2000-2022. Kết quả phân tích bằng mô hình FGLS, nhập khẩu, đầu tư trực tiếp nước ngoài, thương mại hàng hóa có ý nghĩa tác động đáng kể tới xuất khẩu, tuy nhiên mức độ bao phủ mạng di động không có tác động ý nghĩa tới xuất khẩu. Chính phủ có thể tập trung vào các biện pháp thu hút đầu tư trực tiếp nước ngoài, tăng thương mại hàng hóa hoặc gia tăng nhập khẩu, vốn cũng là các yếu tố ảnh hưởng đến xuất khẩu.
POLA ASUH ORANG TUA TERHADAP SOSIAL EMOSIONAL ABK DENGAN ANXIETY DISORDER DI TKIT BUNGA MUFIIDAH
Authors: Lenny Lelly , Anggrayni Rice , Risman Vera , Yunitasari Septiyani Endang
Published: June 2024

Rendahnya kemampuan sosial emosional AC dengan Anxiety Disorder menjadi masalah penelitian. Penelitian menggunakan metode kualitatif melalui observasi, wawancara dan dokumentasi sebagai teknik yang digunakan dalam pengumpulan data. Hasil penelitian menunjukkan bahwa  pola asuh  orangtua AC yang protektif membawa AC pada tingkat kecemasan yang tidak terkendali, AC yang terdiagnosa Anxiety Disorder semakin terbiasa dengan anti sosialnya bahkan berpengaruh pada perkembangan bicaranya, selanjutnya orang tua AC melakukan perubahan pola asuh terhadap AC dari protektif menjadi pola asuh demokratis sehingga terlihat adanya perkembangan sosial emosional yang lebih baik pada AC.
Kata Kunci: Pola Asuh, Sosial Emosional, Anxiety Disorder
PENGARUH KEGIATAN FUN COOKING TERHADAP KECERDASAN INTERPERSONAL ANAK USIA 5-6 TAHUN DI RA DARUSSALAM KECAMATAN PELEPAT ILIR
Authors: Utami Winda Sherly , Indryani Indryani , Azmi Indri Febri
Published: June 2024

Penelitian pengaruh kegiatan fun cooking terhadap kecerdasan interpersonal anak usia 5-6 tahun di RA darussalam kecamatan pelepat ilir ini dilakukan untuk melihat bagaimaan keterkaitan fun cooking berkaitan dengan kecerdasan interpersonal anak usia 5-6 tahun di RA Darussalam Kecamatan Pelepat Ilir. Penelitian ini berjenis kuantitatif eksperimen dengan desain one group pretest-postets. Populasi penelitian ini yaitu setiap anak yang berusia 5-6 tahun dan sampel penelitian ini yaitu kelompok B1 berjumlah 21 anak. 21 anak dijadikan sampel berdasarkan kesamaan usia dan kemampuan yang dimiliki. Data dalam penelitian ini dikumpulkan melalui teknik observasi, dokumentasi, dan melalui instrumen penelitian. Data yang telah didapat, dianalisis menggunakan statistik inferensial berupa pengujian hipotesis yang didahului uji normalitas dan homogenitas data.
Berdasarkan hasil analisis data penelitian terlihat bahwa t hitung sebesar 25,213 > dari t tabel sebesar 2,093 dari taraf signifikan.ɑ: 0.05 Kemudian hasil dari pretest sebesar 11,57 dan hasil postest sebesar 25,00 hasil skor tersebut diperoleh dari hasil uji liliefors. Analisis yang di peroleh dari uji t sebesar 7,15 sehingga Ho di tolak dan Ha diterima. Maka dari hipotesis penelitian “Kegiatan fun cooking terhadap kecerdasan interpersonal anak usia 5-6 Tahun di RA Darussalam Kecamatan Pelepat Ilir” dengan Nilai interprestasi Cohen’s sebesar 7,15 yang berarti berada pada rentang > 1,00 dengan interpertasi tergolong kuat  strong effect.
Aplikasi Pupuk Organik Cair Daun Ketapang dan Penambahan Kapur Dolomit pada Media Tercekam Garam untuk Pertumbuhan dan Hasil Panen Kentang Hitam (Plectranthus rotundifolius)
Authors: Fatmawati Mitha Amanda , Andriani Vivin , Ajiningrum Purity Sabila
Published: June 2024

Black potato production in Indonesia is limited, due to suboptimal cultivation techniques for black potato tubers. Potatoes are generally planted at an altitude above 1000 meters above sea level, because they require low temperatures during the planting process. The aim of this research is to determine the effect of applying liquid organic fertilizer (POC) from ketapang leaves and dolomite lime (CaMgCO3)2 with salt stress media on the growth and yield of black potato plants (Plectranthus rotundifolius). The type of experiment in this research was experimental research using a Randomized Group Design (RAK) which was carried out with 16 treatments, and was repeated 3 times. POC treatment of Ketapang leaves (K) with each concentration, namely K0 (0%), K1 (40%), K2 (60%), K3 (80%), and dolomite lime treatment (C) with each concentration , namely C0 (0g), C1 (20g), C2 (40g), and C3 (80g). Observation variables include plant growth parameters (plant height, number of leaves, stem diameter, and number of branches) and harvest yield parameters (number of tubers and tuber weight). Data analysis used the ANOVA test with a significance level of 0.05. The results of the research showed that giving POC ketapang leaves and dolomite lime had a significant effect on the growth and yield of black potatoes. At plant height, the yield was 24.00 cm, the number of leaves was 25, the number of branches was 5, the stem diameter was 0.90 mm, the number of tubers was 26, and the weight of the tubers was 232 grams.
Ortaokul 5. Sınıf Fen Bilimleri Ders Kitaplarının Değerler Açısından İncelenmesi
Authors: Ünal Suat , Benzer Ali İhsan
Published: June 2024

Bu araştırmanın amacı, ortaokul 5. sınıf fen bilimleri ders kitaplarında yer alan değerleri belirlemek ve incelemektir. Araştırmada, nitel araştırma yöntemlerinden doküman incelemesi yöntemi kullanılmıştır. Çalışmanın veri kaynağı, farklı yayınevleri tarafından basılmış olan ve 2020–2021 eğitim-öğretim yılından itibaren okutulan, iki 5. sınıf fen bilimleri ders kitabıdır. Fen bilimleri ders kitaplarını değerler bakımından incelemek için Talim ve Terbiye Kurulu Başkanlığı tarafından hazırlanmış 10 kök değer sınıflandırması kullanılmıştır. Elde edilen verilerin analizinde betimsel analiz yönteminden yararlanılmıştır. Araştırma sonucunda fen bilimleri ders kitaplarında en fazla “öz denetim” ve “sorumluluk” değerlerinin yer aldığı, buna karşılık “adalet” ve “dostluk” değerlerinden hiç bahsedilmediği, “dürüstlük” ve “saygı” değerlerinden ise sadece bir kez bahsedildiği görülmüştür. Ayrıca incelenen her iki ders kitabında da değerlerin ünitelere göre dağılımının dengeli olmadığı sonucuna ulaşılmıştır. Elde edilen bulgular ışığında fen bilimleri ders kitaplarının tüm kök değerleri içerecek şekilde tekrar düzenlenmesi ve değerleri içeren ifadelerin görsellerle desteklenmesi önerilmektedir.
ANALISIS JABATAN DAN ANALISIS BEBAN KERJA PADA SEKSI PEMBERDAYAAN SOSIAL, PERORANGAN, KELUARGA, KELEMBAGAAN MASYARAKAT, DAN KOMUNITAS ADAT TERPENCIL DINAS SOSIAL PROVINSI SULAWESI SELATAN
Authors: Febriyanti Nurul , Laura Sampe Valentin
Published: June 2024

Analisis jabatan dan analisis beban kerja pada Seksi Pemberdayaan Sosial, Perorangan, Keluarga, Kelembagaan Masyarakat, dan Komunitas Adat Terpencil tidak memiliki seorang yang ahli untuk menyusun analisis jabatan dan analisis beban kerja sehingga terjadi kekeliruan. Pembaharuan analisis jabatan dan analisis beban kerja juga belum dilaksanakan. Berdasarkan permasalahan tersebut, maka penelitian ini bertujuan untuk melakukan pembaharuan dalam hal penyusunan analisis jabatan dan analisis beban kerja sesuai dengan Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Nomor 1 Tahun 2020. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kualitatif. Adapun metode analisis data pada penelitian ini adalah pengumpulan data, reduksi data, penyajian data, penarikan kesimpulan dan verifikasi. Hasil penelitian adalah rancangan analisis jabatan dan analisis beban kerja yang memuat 17 (Tujuh belas) butir informasi jabatan sesuai dengan Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Nomor 1 Tahun 2020 Tentang Pedoman Analisis Jabatan dan Analisis Beban Kerja.
A FORMAÇÃO PRÁTICA E CONTINUADA SOB A ÓTICA DO BANCÁRIO
Authors: Pereira Claudia Aparecida de Araujo , Moreira Alessandro Messias , Gomes Celso Augusto dos Santos
Published: June 2024

Este artigo aborda a formação prática e continuada sob a ótica do bancário. A abordagem se justifica pela exigência da aquisição de novos conhecimentos por tais profissionais. O objetivo é examinar a perspectiva dos bancários em relação à sua formação inicial e continuada, com o intuito de ressaltar suas percepções sobre os processos formativos. Participaram deste estudo 44 sujeitos de uma população de 53, que responderam a um questionário semiestruturado. O software Sphinx® foi utilizado para processar os dados durante a análise de conteúdo, levando em conta o referencial teórico e o contexto da pesquisa. No que diz respeito ao Google Sheets®, possibilitou a limpeza, organização e análise estatística dos dados, bem como a visualização por meio de gráficos, com atenção à segurança das informações. Os resultados obtidos demonstraram, que os sujeitos possuem diferentes graduações e as avaliam como importantes no exercício da profissão e na progressão da carreira, quanto a pós-graduação foi constatado que muitos não cursaram evidenciando o desinteresse e a baixa importância, por sua vez, em relação aos cursos livres ofertados pela instituição bancária, consideraram como relevantes, contudo, eles são vistos como algo que tendem a não atender as necessidades quanto ao exercício da profissão e a progressão na carreira.
Social norms and perceptions of Saudis on active transportation
Authors: Hasan Raed Abdullah , Alhomaidat Fadi , Albdour Mohammad S.
Published: June 2024

The culture of active transportation (walking or cycling) in the Kingdom of Saudi Arabia (KSA) is less prevalent than in other societies. This study aims to understand the perceptions of people in the KSA about the role of cultural dimensions on active transportation. The study was conducted in Jeddah, prominent urban city in Saudi Arabia. The city suffers from rapid growth in vehicle users compared to active transportation. An online survey was employed with around 800 individuals participating from King Abdulaziz University. The results were analysed based on participants’ sex. Few participants reported walking as the mode of transportation from home to work/school and no participants reported using a bicycle as daily commute. Females identify societal tradition and norms as the main factors that impede their engagement in active transportation. Males, who were embarrassed to walk/cycle, defined clothing and social status as the main barriers. Most males and females identify climate (high temperature throughout the year) as one of the main obstacles to walk/bike. Significant social, environmental, and infrastructural predictors of participants’ modal choice were the distance from home to school/workplace, age, social values, family size, citizenship, and road safety.
Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis
Authors: Liu Menghe , Peng Ru , Tian Chunfang , Shi Jianping , Ma Jiannan , Shi Ruiwen , Qi Xiao , Zhao Rongwei , Guan Haibin
Published: June 2024

In recent years, a growing body of research has confirmed that the gut microbiota plays a major role in the maintenance of human health and disease. A gut microbiota imbalance can lead to the development of many diseases, such as pregnancy complications, adverse pregnancy outcomes, polycystic ovary syndrome, endometriosis, and cancer. Short-chain fatty acids are metabolites of specific intestinal bacteria and are crucial for maintaining intestinal homeostasis and regulating metabolism and immunity. Endometriosis is the result of cell proliferation, escape from immune surveillance, and invasive metastasis. There is a strong correlation between the anti-proliferative and anti-inflammatory effects of short-chain fatty acids produced by gut microbes and the development of endometriosis. Given that the mechanism of action of gut microbiota and Short-chain fatty acids in endometriosis remain unclear, this paper aims to provide a comprehensive review of the complex interactions between intestinal flora, short-chain fatty acids and endometriosis. In addition, we explored potential microbial-based treatment strategies for endometriosis, providing new insights into the future development of diagnostic tests and prevention and treatment methods for endometriosis.
Horizon scanning of potential environmental applications of terrestrial animals, fish, algae and microorganisms produced by genetic modification, including the use of new genomic techniques
Authors: Miklau Marianne , Burn Sarah-Joe , Eckerstorfer Michael , Dolezel Marion , Greiter Anita , Heissenberger Andreas , Hörtenhuber Stefan , Zollitsch Werner , Hagen Kristin
Published: June 2024

With scientific progress and the development of new genomic techniques (NGTs), the spectrum of organisms modified for various purposes is rapidly expanding and includes a wide range of taxonomic groups. An improved understanding of which newly developed products may be introduced into the market and released into the environment in the near and more distant future is of particular interest for policymakers, regulatory authorities, and risk assessors. To address this information need, we conducted a horizon scanning (HS) of potential environmental applications in four groups of organisms: terrestrial animals (excluding insects and applications with gene drives), fish, algae and microorganisms. We applied a formal scoping review methodology comprising a structured search of the scientific literature followed by eligibility screening, complemented by a survey of grey literature, and regulatory websites and databases. In all four groups of organisms we identified a broad range of potential applications in stages of basic as well as advanced research, and a limited number of applications which are on, or ready to be placed on, the market. Research on GM animals including fish is focused on farmed animals and primarily targets traits which increase performance, influence reproduction, or convey resistance against diseases. GM algae identified in the HS were all unicellular, with more than half of the articles concerning biofuel production. GM algae applications for use in the environment include biocontrol and bioremediation, which are also the main applications identified for GM microorganisms. From a risk assessor’s perspective these potential applications entail a multitude of possible pathways to harm. The current limited level of experience and limited amount of available scientific information could constitute a significant challenge in the near future, for which risk assessors and competent authorities urgently need to prepare.
Inhibition of miRNA associated with a disease-specific signature and secreted via extracellular vesicles of systemic lupus erythematosus patients suppresses target organ inflammation in a humanized mouse model
Authors: Young Nicholas A. , Schwarz Emily , Zeno Braden M. , Bruckner Shane , Mesa Rosana A. , Jablonski Kyle , Wu Lai-Chu , Roberson Elisha D. O. , Jarjour Wael N.
Published: June 2024

Introduction

Distinct, disease-associated intracellular miRNA (miR) expression profiles have been observed in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematous (SLE) patients. Additionally, we have identified novel estrogenic responses in PBMCs from SLE patients and demonstrated that estrogen upregulates toll-like receptor (TLR)7 and TLR8 expression. TLR7 and TLR8 bind viral-derived single-stranded RNA to stimulate innate inflammatory responses, but recent studies have shown that miR-21, mir-29a, and miR-29b can also bind and activate these receptors when packaged and secreted in extracellular vesicles (EVs). The objective of this study was to evaluate the association of EV-encapsulated small RNA species in SLE and examine the therapeutic approach of miR inhibition in humanized mice.

Methods

Plasma-derived EVs were isolated from SLE patients and quantified. RNA was then isolated and bulk RNA-sequencing reads were analyzed. Also, PBMCs from active SLE patients were injected into immunodeficient mice to produce chimeras. Prior to transfer, the PBMCs were incubated with liposomal EVs containing locked nucleic acid (LNA) antagonists to miR-21, mir-29a, and miR-29b. After three weeks, blood was collected for both immunophenotyping and cytokine analysis; tissue was harvested for histopathological examination.

Results

EVs were significantly increased in the plasma of SLE patients and differentially expressed EV-derived small RNA profiles were detected compared to healthy controls, including miR-21, mir-29a, and miR-29b. LNA antagonists significantly reduced proinflammatory cytokines and histopathological infiltrates in the small intestine, liver, and kidney, as demonstrated by H&E-stained tissue sections and immunohistochemistry measuring human CD3.

Discussion

These data demonstrate distinct EV-derived small RNA signatures representing SLE-associated biomarkers. Moreover, targeting upregulated EV-encapsulated miR signaling by antagonizing miRs that may bind to TLR7 and TLR8 reveals a novel therapeutic opportunity to suppress autoimmune-mediated inflammation and pathogenesis in SLE.
Assessing the predictive value of smoking history for immunotherapy outcomes in bladder cancer patients
Authors: Kong Jianqiu , Zou Yitong , Zhou Hua , Huang Yi , Lin Ying , Fang Shuogui , Chen Zhijian , Zheng Junjiong , Huang Yaqiang , Shen Zefeng , Xie Weibin , Fan Xinxiang
Published: June 2024

Background

The therapeutic effectiveness of immune checkpoint inhibitors (ICIs) in bladder cancer varies among individuals. Identifying reliable predictors of response to these therapies is crucial for optimizing patient outcomes.

Methods

This retrospective study analyzed 348 bladder cancer patients treated with ICIs, with additional validation using data from 248 patients at our institution who underwent PD-L1 immunohistochemical staining. We examined patient smoking history, clinicopathological characteristics, and immune phenotypes. The main focus was the correlation between smoking history and immunotherapy outcomes. Multivariate logistic and Cox proportional hazard regressions were used to adjust for confounders.

Results

The study cohort comprised 348 bladder cancer patients receiving ICIs. Among them, 116 (33.3%) were never smokers, 197 (56.6%) were former smokers (median pack-years = 28), and 35 (10.1%) were current smokers (median pack-years = 40). Analysis revealed no statistically significant difference in overall survival across different smoking statuses (objective response rates were 11.4% for current smokers, 17.2% for never smokers, and 22.3% for former smokers; P = 0.142, 0.410, and 0.281, respectively). However, a notable trend indicated a potentially better response to immunotherapy in former smokers compared to current and never smokers. In the validation cohort of 248 patients from our institution, immunohistochemical analysis showed that PD-L1 expression was significantly higher in former smokers (55%) compared to current smokers (37%) and never smokers (47%). This observation underscores the potential influence of smoking history on the tumor microenvironment and its responsiveness to ICIs.

Conclusion

In conclusion, our study demonstrates the importance of incorporating smoking history in predicting the response to immunotherapy in bladder cancer patients, highlighting its role in personalized cancer treatment approaches. Further research is suggested to explore the comprehensive impact of lifestyle factors on treatment outcomes.
Broadening inclusivity at sea
Authors: Wang Lu , Adams Caitlin , Fundis Allison , Hsiao Janet , Machado Casey , Malik Mashkoor , Quadara Rachel , Rodriguez Coralie , Soule Adam , Suhre Kelley , Wu Liang , Elmore Aurora C.
Published: June 2024

Ocean sciences in the U.S. remains a field with one of the lowest rates of diversity, having disproportionately low representation from marginalized groups, including Black, Asian, LatinX, Indigenous, and other people of color; LGBTQIA+ individuals; disabled persons; women; those with neurological differences; and those from low-income groups. With equity and inclusion in mind, recent efforts have been made to increase the number of ocean science professionals from marginalized groups through multiple entry points, including internships. However, there still exists a large gap between the diversity found in the general population and the diversity within ocean sciences. Perhaps one reason why this field continues to have lower diversity owes to the unique component of many oceanographic careers, which continues to present an especially high barrier for marginalized groups: participating in sea-going research expeditions. Herein, we have synthesized possible ways to prioritize the physical and emotional safety of marginalized ocean science professionals participating in a research expedition, including guidance on preparation, implementation, and providing support post-cruise. These suggestions are intended to be useful for the broader oceanographic research community to consider the safety and well-being of individuals from marginalized groups at sea, since the field of ocean sciences - like all fields - would greatly benefit from increased representation and diversity.
Self-administered gerocognitive examination (SAGE) aids early detection of cognitive impairment at primary care provider visits
Authors: Scharre Douglas W. , Vrettos Nicole E. , Nagaraja Haikady N. , Wexler Randell K. , Clark Aaron D. , Nguyen Christopher M.
Published: June 2024

Introduction

Current estimates indicate that up to 50–75% of dementia cases are undiagnosed at an early stage when treatments are most effective. Conducting robust accurate cognitive assessments can be time-consuming for providers and difficult to incorporate into a time-limited Primary Care Provider (PCP) visit. We wanted to compare PCP visits with and without using the self-administered SAGE to determine differences in identification rates of new cognitive disorders.

Methods

Three hundred patients aged 65–89 without diagnosed cognitive disorders completing a non-acute office visit were enrolled (ClinicalTrials.gov identifier: NCT04063371). Two PCP offices conducted routine visits for 100 consecutive eligible patients each. One office used the SAGE in an additional 100 subjects and asked available informants about cognitive changes over the previous year. Chart reviews were conducted 60 days later. One-way analysis of variance and Fisher exact tests were used to compare the groups and outcomes.

Results

When SAGE was utilized, the PCP documented the detection of new cognitive conditions/concerns six times (9% versus 1.5%) as often (p = 0.003). The detection rate was nearly 4-fold for those with cognitively impaired SAGE scores (p = 0.034). Patients having impaired SAGE score and informant concerns were 15-fold as likely to have new cognitive conditions/concerns documented (p = 0.0007). Among providers using SAGE, 86% would recommend SAGE to colleagues.

Discussion

SAGE was easily incorporated into PCP visits and significantly increased identification of new cognitive conditions/concerns leading to new diagnoses, treatment, or management changes. The detection rate increased 15-fold for those with impaired SAGE scores combined with informant reports.
Evidence for peripheral and central actions of codeine to dysregulate swallowing in the anesthetized cat
Authors: Bolser Donald C. , Shen Tabitha Y. , Musselwhite M. Nicholas , Rose Melanie J. , Hayes John A. , Pitts Teresa
Published: June 2024

Systemic administration of opioids has been associated with aspiration and swallow dysfunction in humans. We speculated that systemic administration of codeine would induce dysfunctional swallowing and that this effect would have a peripheral component. Experiments were conducted in spontaneously breathing, anesthetized cats. The animals were tracheotomized and electromyogram (EMG) electrodes were placed in upper airway and chest wall respiratory muscles for recording swallow related motor activity. The animals were allocated into three groups: vagal intact (VI), cervical vagotomy (CVx), and supra-nodose ganglion vagotomy (SNGx). A dose response to intravenous codeine was performed in each animal. Swallowing was elicited by injection of 3 mL of water into the oropharynx. The number of swallows after vehicle was significantly higher in the VI group than in SNGx. Codeine had no significant effect on the number of swallows induced by water in any of the groups. However, the magnitudes of water swallow-related EMGs of the thyropharyngeus muscle were significantly increased in the VI and CVx groups by 2–4 fold in a dose-related manner. In the CVx group, the geniohyoid muscle EMG during water swallows was significantly increased. There was a significant dose-related increase in spontaneous swallowing in each group from codeine. The spontaneous swallow number at the 10 mg/kg dose of codeine was significantly larger in the CVx group than that in the SNGx group. During water-evoked swallows, intravenous codeine increased upper airway motor drive in a dose-related manner, consistent with dysregulation. The data support the existence of both central and peripheral actions of codeine on spontaneous swallowing. At the highest dose of codeine, the reduced spontaneous swallow number in the SNGx group relative to CVx is consistent with a peripheral excitatory action of codeine either on pharyngeal/laryngeal receptors or in the nodose ganglion itself. The higher number of swallows in the CVx group than the VI group supports disinhibition of this behavior by elimination of inhibitory vagal sensory afferents.
Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells
Authors: Baniya Manoj Kumar , Kim Eun-Hee , Chun Kyung-Soo
Published: June 2024

Introduction

Colorectal cancer is a highly aggressive and metastatic cancer with inadequate clinical outcomes. Given the crucial role of histamine and histamine receptors in colorectal carcinogenesis, this study aimed at exploring the anticancer effects of terfenadine against colorectal cancer HCT116 cells and elucidate its underlying mechanism.

Methods

Herein, we examined the effect of terfenadine on growth and proliferation of HCT116 cells in vitro and in vivo. Various experimental techniques such as flow cytometry, western blot, immunoprecipitation, luciferase assay were employed to unveil the mechanism of cell death triggered by terfenadine.

Results

Terfenadine markedly attenuated the viability of HCT116 cells by abrogating histamine H1 receptor (H1R) signaling. In addition, terfenadine modulated the balance of Bax and Bcl-2, triggering cytochrome c discharge in the cytoplasm, thereby stimulating the caspase cascade and poly-(ADP-ribose) polymerase (PARP) degradation. Moreover, terfenadine suppressed murine double minute-2 (Mdm2) expression, whereas p53 expression increased. Terfenadine suppressed STAT3 phosphorylation and expression of its gene products by inhibiting MEK/ERK and JAK2 activation in HCT116 cells. Furthermore, treatment with U0126, a MEK inhibitor, and AG490, a JAK2 inhibitor, dramatically diminished the phosphorylations of ERK1/2 and JAK2, respectively, leading to STAT3 downregulation. Likewise, terfenadine diminished the complex formation of MEK1/2 with β-arrestin 2. In addition, terfenadine dwindled the phosphorylation of PKC substrates. Terfenadine administration (10 mg/kg) substantially retarded the growth of HCT116 tumor xenografts in vivo.

Conclusion

Terfenadine induces the apoptosis of HCT116 cells by abrogating STAT3 signaling. Overall, this study supports terfenadine as a prominent anticancer therapy for colorectal cancer.
Effects of four types of natural bait on water quality, feeding, growth, and antioxidant enzyme activity of Monopterus albus in a recirculating aquaculture system
Authors: Yuan Quan , Wu Chengcheng , Yang Hang , Lv Weiwei , Huang Weiwei , Zhang Qinghua , Zhou Wenzong
Published: June 2024

Monopterus albus is one of China’s renowned and superior aquaculture species, with its seedlings mainly sourced from wild capture. One of the bottlenecks in M. albus aquaculture is the high mortality rate and low feeding initiation rate from stocking wild fry to the initiation of feeding. In production, trash fish is commonly used to wean M. albus juveniles onto feeding. In this study, we introduced three other natural feeds, earthworms (EW), yellow mealworms (YMW), and fly maggots (FM), with frozen trash fish (TF) serving as the control group, to evaluate the effects of these four natural feeds on the survival rate, feeding initiation, antioxidant enzymes activity, and body composition of M. albus juveniles under recirculating water aquaculture conditions. The experiment comprised four treatments, each with three replicates. Each replicate consisted of stocking 150 M. albus juveniles weighing 10.02 ± 0.89 g in size, raised for 5 weeks. The survival rate of the YMW group was 73.33%–85.33%, which was significantly higher than that of the other three bait groups (p < 0.05). The four bait groups showed no significant differences in final body weight and specific growth rate (SGR) (p > 0.05). The EW group showed the highest final body weight, with an average SGR of 2.73, whereas the YMW group had an average SGR of 1.87. The average daily feeding amount was significantly higher in EW and YMW groups than in the other two groups (p < 0.05). The percentage of feeding amount to fish weight in the EW group reached 7.3% in the fifth week. After 5 weeks of cultivation, NO2−-N content was significantly higher in the waters of the TF and EW groups than in the waters of the FM and YMW groups (p < 0.05), there was no significant difference in TAN content among the treatment groups (p > 0.05). Liver malondialdehyde content was significantly higher in the TF group than in the other bait groups (p < 0.05). GSH-Px activity was significantly higher in the EW group than in the FM group and YMW group. No significant differences in SOD and CAT activity and T-AOC were observed among the bait groups (p > 0.05). The increase in crude protein content was significantly higher in the TF group than in the FM group, but the increase in crude ash content was significantly lower in the TFgroup. In conclusion, Tenebrio molitor could potentially serve as one of the alternative feeds during the initial stages of M. albus juveniles stocking.
Motivation and guidance of college students’ low-carbon behavior: evidence from Chinese colleges and universities
Authors: Ren Gaofei , Liu Changjin , Chen Yaoyao
Published: June 2024

In the context of the global implementation of the emission peak and carbon-neutral strategic goal, guiding residents’ low-carbon behavior is of great significance for the realization of the dual carbon goal. However, existing studies have paid less attention to the low-carbon behavior of college students. Based on the theory of planned behavior, this paper constructs a theoretical model of influencing factors of college students’ low-carbon behavior. Combined with 612 questionnaires from Chinese colleges and universities, this study uses a structural equation model and multi-group analysis method to explore the motivation of college students’ low-carbon behavior and guiding education strategies. The results show that low-carbon attitude, subjective norms, low-carbon values, and perceived behavior control have significant positive effects on low low-carbon behavior intention of college students, and influence their low-carbon behavior through low-carbon behavior intention. Further research found that gender and growth environment (urban vs. rural) presented heterogeneity in different influence paths, and the perceived cost had a significant negative moderating effect during the transition from low-carbon intention to low-carbon behavior. These research findings provide a theoretical basis and policy inspiration for explaining and guiding the low-carbon behavior of college students.