bluuebunny/crossref_metadata_2025 huggingface dataset:
Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer
Authors: Batista Thales Paulo , Santana Rafael Palmeira , Augusto Camilla Maria Guimarães , Morais Nivaldo Sobral , Ventura Maria Lídia Amaral Barbosa , Bezerra Artur Lício Rocha
Published: April 2022

Objective: We sought to re-explore the association between well-known prognostic factors and recurrence in presumed early-stage low-risk endometrial cancer (EC).

Methods: A retrospective cohort study was carried out on patients who underwent surgical treatment by the same surgeon for presumed early-stage low-risk EC between September 2003 to August 2017. The prognostic value of well-known clinicopathological factors for diseasefree survival (DFS) was reviewed by univariate log-rank test.

Results: One hundred and five patients fit the criteria for this analysis. These patients underwent total hysterectomy plus bilateral salpingo-oophorectomy with no lymph nodes dissection (10.5%) or with a sampling dissection alone (89.5%). Adjuvant therapies were applied in 52 (40.1%) of them as pelvic radiotherapy (29.5%) or chemoradiation (11.4%). Our cumulative 3y-DFS and OS were 88.1% and 97.7%, respectively. The univariate survival analysis confirmed histological grade 3 (3y-DFS of 89.9% vs. 33.3%, p=0.004), MMI ≥50% (3y-DFS of 95.2% vs. 71.3%, p=0.003), lymph node metastasis (3y-DFS of 88.3% vs. 60%; p=0.028) and more advanced pathological stages (3y-DFS of 91.2% vs. 56.3; p<0.001) as significantly associated to recurrences.

Conclusion: We confirmed the association of classical prognostic factors such as high histological grade, deeper MMI, lymph node metastasis and more advanced pathological stages with disease recurrence in this cohort of patients from Northeast Brazil. Further efforts are needed to avoid overtreatment in patients with low risk of relapses.
Pediatric related risk factors in acute and delayed chemotherapyinduced nausea and vomiting: multivariate analysis
Authors: Albuquerque Ariádne Sousa , Okumura Lucas Miyake , Betin-de-Moraes Nelci Rodrigues , Ricieri Marinei Campos , Barros Tais Tereziano , Fachi Mariana Millan
Published: April 2022

Objectives: This study aimed to characterize the clinical profile and the factors that predispose chemotherapy-induced nausea and vomiting (CINV) in the acute and delayed phases.

Methods: A retrospective cohort study was conducted in a Brazilian hospital with pediatric patients under 18 years old receiving moderately or highly emetogenic chemotherapy. Thus, a descriptive analysis was performed to characterize this population, followed by univariate and multivariate analysis to evaluate the risk factors for CINV. In both phases, considering significant the variables with p-values <0.05.

Results: The median age was 6 and 71% of the patients included used highly emetogenic protocols. Furthermore, 41% and 76% did not have vomit in the acute and delayed phase, respectively. Through logistic regression, it is noted that patients with bone tumors and sarcomas have higher CINV in the acute phase (OR 10.0, 95%IC 1.1-88.9, p=0.039), while patients who do not have complete control in the acute phase are more likely to have CINV in the delayed phase (OR 11.8, 95%IC 1.1-130.5, p=0.044).

Conclusion: These results suggest that bone tumors and sarcomas are associated with an increase in CINV in the acute phase. In addition, control in the acute phase is associated with a complete response in the delayed phase.
Safe prescription of systemic antineoplastic treatment in oncology: integrative literature review
Authors: Alves Fabiola Vasconcelos , Silveira Renata Cristina de Campos Pereira , Cruz Flavia Oliveira de Almeida Marques da , Ferreira Elaine Barros , Reis Paula Elaine Diniz dos
Published: April 2022

The objective of this study was to identify the available evidence on the parameters that should be considered to improve the quality and safety of the prescription of systemic antineoplastic treatment. This is an integrative review carried out in the EMBASE, LILACS, and PubMed databases, from 2015 to 2019. The methodological quality of the included studies was assessed by the tools of the Joanna Briggs Institute. Eight studies were included, of which 5 addressed adverse events related to systemic antineoplastic treatment, including 4,970 patients treated with immunotherapy, target therapy, and chemotherapy. One study assessed the safety of prescribing antineoplastic agents and 2 studies addressed pharmacovigilance and risk management by assessing treatment- related adverse effects. Chemotherapy, target therapy, and immunotherapy have different toxicity profiles. The evidence suggests that assessment of treatment toxicity as well as risk management should be considered to improve the quality and safety of prescribing systemic antineoplastic treatment.
Physical activity recommendations for cancer prevention and control: a Brazilian consortium
Authors: Deminice Rafael , Rezende Leandro F M , Rosa Daniela Dornelles , Cangussu Renata , Garcia Leandro Martin Totaro , Riera Rachel , Carvalho Fabio Fotunato Brasil , Silva Ronaldo Côrrea Ferreira , Brum Patrícia Chakur
Published: April 2022

Objective: This article describes the development process and summarizes the results of the Brazilian physical activity recommendations for cancer prevention and control, which was prepared to support health-care professionals.

Material and Methods: These recommendations were elaborated considering: (i) the effect of physical activity on cancer prevention in the general healthy population; and (ii) on all-cause and cancer-specific mortality in cancer survivors. The process of preparing the recommendations was systematized, transparent and reproducible, following the recommendations of the appraisal of guidelines for research and evaluation (AGREE-II). We appraised the certainty of evidence for breast, prostate, colorectal and lung cancers, which are among the most frequent in Brazil, using the grading of recommendations, assessment, development and evaluations (GRADE) approach.

Results: Regarding the risk of cancer, we found high certainty of evidence supporting the association between moderate-to-vigorous physical activity and lower risk of breast and colon cancer, moderate certainty of evidence for lung cancer and low certainty of evidence for prostate and rectal cancer. We found moderate certainty of evidence supporting the association between moderate-to-vigorous physical activity and reduction of all-cause and cancer-specific mortality from breast, colon and rectal cancer, and cancer-specific mortality from prostate cancer, when physical activity was performed after the disease diagnosis. We found low certainty of evidence for the association between physical activity and lung cancer mortality. Based on our findings, physical activity recommendations were proposed, including a step-by-step guide to support health-care professionals when recommending physical activity for all adults (including elderly people), with or without a diagnosis of cancer.

Conclusion: Our recommentations may be useful to support health-care professionals counselling for physical activity, which contribute to reductions in physical inactivity in the general population and in the growing population of cancer survivors.
Femvertising: estratégia de empoderamento feminino nas propagandas
Authors: Correia Junia Maria Santos , Antunes Miquelle Rodrigues , Pinho Natércia dos Santos , Silva Sheldon William , Gonçalves Janice Queiroz de Pinho , Carvalho João Francisco Sarno
Published: April 2022

É notável a evolução e crescimento do movimento feminista, bem como a mudança no posicionamento das mulheres frente à sociedade e aos estereótipos existentes. Sendo assim, as empresas estão apostando no femvertising, na utilização da publicidade como forma de enaltecer e valorizar o empoderamento feminino. Nesse contexto, o presente artigo tem como objetivo verificar se as narrativas preexistentes em propagandas se encontram aderentes ao femvertising. Como premissa, buscou-se contextualizar a publicidade como ferramenta de marketing, a compreensão do gênero ao longo da história e, como consequência, o surgimento do femvertising. A metodologia caracteriza- se por uma descrição qualitativa em que foram analisadas três propagandas de empresas de distintos segmentos: Renault, a Nike e a Rexona. Como conclusão, foi possível mensurar que as propagandas de fato enaltecem a mulher, não se tornando apenas estratégias de comunicação para atrair consumidores como o senso comum acredita ser.
Guiana Francesa, entre o pós-colonialismo e a afirmação nacional
Authors: Souza Charles Benedito Gemaque
Published: April 2022

A Guiana Francesa é uma região administrativa da França na Pan-Amazônia, caracterizada pelo encontro e desencontro de etnias as quais são uma expressão dessa sociedade conflitante e, como tal, revela as contradições inscritas nas representações e nos territórios, bem como nas estratégias de poder elaboradas pelo choque de interesses. A França, adepta do universalismo, busca no distanciamento de qualquer memória estranha (experiência empírica) a consolidação de seus traços culturais. Assim, o modelo estatal francês de integração não tolera as diferenças seja aquelas trazidas pelos imigrantes ou originarias dos povos colonizados. Nas antigas possessões francesas esse processo de descolonização, de integridade moral constitui um verdadeiro “eufemismo” da velha política de dominação colonial, criando divisões sociais.
Fauna do solo e classificações ecológicas utilizadas
Authors: Silva `Clécio Danilo Dias
Published: April 2022

O trabalho teve como objetivo discutir aspectos introdutórios sobre a fauna do solo. Em seu escopo são apresentados: i) conceito de fauna do solo; ii) a classificação adotada conforme a estrutura corporal dos organismos; iii) classificação de grupos funcionais partindo do critério trófico; iv) classificação mediante as funções específicas e processos que os organismos cumprem no solo. Diante das discussões efetivadas, pode se inferir que as pesquisas sobre a fauna do solo ainda são incipientes no Brasil, o que evidencia a importância de investimento em projetos de pesquisa, programas de pós-graduação e na formação de pesquisadores, visando ampliar os estudos envolvendo a fauna edáfica em seus diversos aspectos, sejam eles taxonômicos, filogenéticos, ecológicos, dentre outros.
Legalizing Love
Authors: Garrett Katherine , Elements
Published: April 2022

This paper analyzes how the state-level legalizations and national legalization of gay marriage affected the number of children adopted in the United States—both on average and in each of the five age groups. To this end, this paper uses a difference regression using data from the Kids Count Data Center, which details the number of children in each of five age groups adopted each year from 2000 to 2017. This regression analysis found a 9.1% increase in the number of total adoptions after the 2016 national legalization of gay marriage. However, the analysis also found that a state’s legalization was correlated with an 8% decrease in adoptions in that state, creating a complexity in the results that underlines the need for further research. However, the difference in effect between state-level and national legalizations may imply that the barriers to gay couples adopting in the United States may be more cultural than explicitly legal.
The Influential Factors in Improving the Spatial Abilities of Architecture Students
Authors: Kosić-Jeremić Sandra , Ilic Maja , Papaz Dajana
Published: April 2022

In this paper, the factors that influence the improvement of spatial abilities of architecture students were examined. The main question was whether the course in Descriptive Geometry at the Faculty of Architecture, Civil Engineering, and Geodesy at the University of Banja Luka had an impact on students' spatial abilities. The study examined 118 students of the first year comparing their success at Spatial Ability tests in relation to whether they attended the Descriptive Geometry course. The obtained results of the study showed a significant improvement in students' spatial abilities in general and that the Descriptive Geometry course did not have a substantial influence on spatial abilities development. The SPSS v.20 analytical-statistical software package is used for the statistical analysis.
Critical Resistance of a Hut – in Six Points (Cultivation of Critical Practice Through the Memorial House Design by the Architect Ranko Radović)
Authors: Radulj Marina , Milić Aleksić Maja , Šukalo Ognjen
Published: April 2022

This paper deals with the importance of critical design practice in order to nurture, cultivate and build architectural culture. The main goal is to analyse the Memorial House in the Sutjeska National Park, designed by the architect Ranko Radović, through the scientific description, using Kenneth Frampton’s theoretical text “Towards Critical Regionalism - Six Points for an Architecture of Resistance” as an analytical method. In a broader sense, the paper aims to draw attention to the idea of critical practice in modern circumstances by researching the design methodologies and principles based on tradition. The research result is important for contemporary architectural theory and practice in our region and beyond. It indicates the importance of learning architecture based on knowledge and transferring the knowledge gained through the critical practice of our architectural heritage as one of the possible ways to rethink the architectural profession in contemporary conditions of its evident marginalisation under the force of the capital and universalisation of the built environment.
Assessing the Benefits of Nature-Based Solutions in a Storm Drainage System – a Case Study
Authors: Topalović Žana
Published: April 2022

In most developing countries, stormwater drainage practice consists of a conventional storm drainage system designed to collect and convey excess runoff to the recipient as soon as possible, without any attenuation or peak flow decreasing effects. This paper aims to show the overall need for change in the urban drainage paradigm by showing the effects of reconstruction of the existing conventional stormwater drainage system into a new one by including green elements. Part of the existing system is replaced with vegetated swales, and two detention ponds are added in the common green areas (parks). Effects are analysed through a comparison of results from a mathematical rainfall-runoff model for the existing and reconstructed stormwater drainage system for both water quality and quantity at the sub-basin outlet point. The cost-effectiveness of the applied measures is quantified by comparing construction prices for the existing and the reconstructed system. The obtained results clearly show an urgent need for stormwater drainage practice improvement in countries where the conventional approach is still in use.
Accuracy Analysis of GNSS Permanent Station Coordinates Using the Least Square Method by Processing Broadcast and Precise Ephemerides
Authors: Đukanović Tanja , Tucikešić Sanja , Antunović Biljana
Published: April 2022

This paper analyses how broadcast and precise ephemerides in alignment, using the least-squares method, affect the accuracy of coordinates of the newly included permanent stations. It has been shown that in practice, when аdjusting networks whose span between points exceeds 50 km, the adjustment procedure should be carried out using the adopted precise ephemerides for a specific observation period. Precise ephemerides are recommended for 30 to 50 km baseline lengths, while adjustments with broadcast ephemerides achieves satisfactory accuracy for shorter lengths. For baseline lengths of 30 to 50 km, the use of precise ephemerides is recommended, and for shorter lengths, adjustment with broadcast ephemerides achieves satisfactory accuracy. This paper analyses statistics and presents standard deviations of horizontal and vertical positions, when broadcast and precise ephemerides are applied.
MEĐUGENERACIJSKE VRIJEDNOSNE ORIJENTACIE I VRIJEDNOSNI PRIORITETI
Authors: Bolčević Novak Valentina , Mrnjaus Kornelija
Published: April 2022

Vrijednosti imaju prepoznatljivu ulogu u životu svakog pojedinca i društva, a pitanja poput: Za koje je vrijednosti potrebno odgajati? Koje su vrijednosne orijentacije i vrijednosni prioriteti mladih? Postoje li razlike u vrijednosnim orijentacijama i vrijednosnim prioritetima mlađih i starijih generacija? uvijek su aktualna. U ovom se radu predstavljaju rezultati istraživanja kojem je cilj bio ispitati vrijednosne orijentacije i vrijednosne prioritete djece i njihovih roditelja kako bi se ukazalo na (ne)postojanje međugeneracijskog prijenosa vrijednosti u obitelji. Rezultati istraživanja pokazali su kako djeca i njihovi roditelji iskazuju sličnosti u svojim vrijednosnim prioritetima, što upućuje na postojanje međugeneracijskog prijenosa vrijednosti. Oslanjajući se na postavke Schwartzove teorije univerzalnog sadržaja i strukture vrijednosti, pokazalo se kako obje skupine ispitanika značajnim procjenjuju vrijednosti koje pripadaju motivacijskim tipovima vrijednosti univerzalizam, nezavisnost i dobrohotnost, dok najmanje značajnima procjenjuju vrijednosti koje pripadaju tipovima moć, tradicija i postignuće. Ispitivanjem povezanosti vrijednosnih orijentacija djece i njihovih roditelja prema deset motivacijskih tipova vrijednosti, utvrđeno je da povezanost postoji s obzirom na motivacijske tipove vrijednosti moć, tradicija, konformizam i sigurnost.
UTICAJ ASISTIRANE REPRODUKTIVNE TEHNOLOGIJE NA PORODICU I RODITELJSTVO U SAVREMENOM DRUŠTVU
Authors: Vilić Dragana
Published: April 2022

Novu realnost i revolucionarnu promjenu u stvaranju i rađanju potomstva donosi smještanje ovih procesa u laboratorijske uslove. Biomedicinski i tehnološki posredovanom (i kontrolisanom) produkcijom i reprodukciji ljudskog života, primjenom asistirane reproduktivne tehnologije, omogućeno je ostvarenje u roditeljskoj ulozi (biološki i/ili socijalno), osobama koje žive u heteroseksualnom ili homoseksualnom bračnom/partnerskom odnosu i ženama koje žive same, nezavisno o reproduktivnom ciklusu žene. Dijete rođeno na ovaj način može biti biološki ili genetski povezano sa oba ili sa jednim od socijalnih roditelja. Primjena prakse asistirane reprodukcije proširuje (čini fleksibilnijim) granice prirode i kulture, koliko je to zakonom omogućeno, čime se transformišu društveni i kulturološki obrasci i poimanje konvencionalih (socioloških) koncepata braka/partnerstva, roditeljskih uloga, srodstva i rodne ravnopravnosti, te proširuje cilj ove prakse izvan tretiranja neplodnosti. Masovnost primjene asistirane reproduktivne tehnologije i njena globalna ekspanzija, donijeli su brojne izazove na individualnom i na društvenom nivou. Sve ovo podstaklo je feminističke rasprave o načinu na koji se uspostavlja ili gubi odnos između biomedicinske i tehnološke produkcije i sociobiološke reprodukcije ljudskog života, identifikovanju rodne specifičnosti genetike i nove reproduktivne tehnologije, komodifikaciji reproduktivnog rada žene i sl.
OPŠTA TEORIJSKA RAZMATRANJA MEĐUGENERACIJSKIH ODNOSA U SAVREMENOJ PORODICI
Authors: Slijepčević Dušanka
Published: April 2022

Cilj (naučnog) članka jeste naučno objašnjenje, sa sociološkog aspekta, međugeneracijskih odnosa kao društvenih odnosa, u savremenoj porodici kao društvenoj grupi. Otuda je predmet istraživanja moguće formulisati idejnim rješenjem: Kakvi su intergeneracijski odnosi roditelja i njihove djece u savremenoj porodici postmodernog tipa? Koja je uloga roditelja u porodici na prelazu iz XX u XXI vijek? Koja je uloga porodice u društvu postmoderne? Odgovore na istraživačka pitanja omogućuju opšte naučne metode: analiza, sinteza, indukcija i dedukcija. Istraživački rezultati se odnose na proširenje spoznaje o odnosima, ulogama i funkcijama porodice u postmodernom društvu odnosno na saznanje 1) da su porodični odnosi najvećim dijelom egalitarnog tipa zbog prenosa vaspitno-obrazovnih funkcija na druge društvene institucije, usljed čega 2) roditeljski odnos prema djeci konsekventno postaje jednodimenzionalan tj. redukovan samo na pružanje roditeljske ljubavi i topline, a ne i na sprovođenje roditeljske kontrole djeteta, kao što je ranije bio slučaj; 3) te da je uloga porodice u savremenom društvu za ljude, kao društvena bića, i njihove organizacione oblike društvenosti nezamjenjiva i neporeciva tokom istorije ljudskog roda, ali da je, u postmodernom kontekstu, prevashodno emocionalnog karaktera, pri čemu je spoznaja iste provizorna, usljed konstantnih društvenih i porodičnih promjena, ali i zbog postmodernizma kao dominirajuće slike svijeta, koja protežira relativizam pojmovnih određenja odnosno otpor tiraniji definisanja.
GENDER FEATURES OF MODERN PRESCHOOLERS’ MANIFESTATION OF ANXIETY
Authors: Bakhotskaya Maria
Published: April 2022

The author of the article considers gender features of manifestation of anxiety as a negative emotion that detrimentally affects physical and psychological state of a preschool child. The article considers the most significant factors in relation to the gender characteristics of anxiety in preschool children, and determines criteria for parental influence, family structure, and parental attitude to the child.
DRUŠTVO I PORODICA – ISTORIJSKA POVEZANOST I MEĐUSOBNA USLOVLJENOST
Authors: Buvač Mišel
Published: April 2022

U ovome radu pokušaćemo da analiziramo pojmove poput porodice i društva i da iste međusobno povežemo istorijskim činjenicama sa naučnog aspekta. Porodica je prošla mnoge faze promjene koje su joj dale različit pečat, svaka na svoj način. Ista situacija bila je i sa društvom, koje se sa istorijskog aspekta mijenjalo i dobijalo različite forme. Kada je riječ o društvu ono je shvaćeno kao najšira, najsloženija i osnovna ljudska zajednica koja nastaje i razvija se u određenom istorijskom periodu. Sa druge strane, porodica predstavlja istorijsku kategoriju i ćeliju društva ili bolje rečeno označena je kao primarna, biološka i edukativna grupa. Pod raznim ekonomskim, kulturnim, političkim, globalizacijskim, sociološkim i drugim uticajima, društvo na taj način postaje sve heterogenije, složenije i diferencijanije, a društveni odnosi se reflektuju na porodicu a time i na društvo u cjelini. Najbolji opis društva i porodice uopšte, napravio je Herbert Spenser (mada ne jedini autor) kada je rekao da kao što se čovjek sastoji od organa (bez kojih ne može da funkcioniše) tako se i društvo sastoji od institucija, a jedna od njih je i porodica.Od svih promjena u svijetu nijedna nije važnija od one koja se dešava u samoj našoj privatnosti – u porodičnom okruženju. Na sceni je globalno razumijevanje porodice, porodičnih odnosa, veza koje postoje između raznih grupa u društvenom sistemu.Javljaju se mnoga pitanja povodom svih ovih stvari – previše ih je da bismo na njih odgovorili u jednom zaista kratkom radu. Zato ćemo nastojati da se što ozbiljnije pozabavimo pitanjima koja nam se nameću. Na kraju možemo zaključiti da je tradicionalna porodica pred izazovima savremenosti i kao takva daje nam priliku da porodicu i društvo, prvenstveno kao istorijske pojave, posmatramo iz jednog drugog ugla (naučnog i teorijskog prije svega), pokušavajući da objasnimo kuda to danas, prvenstveno, procesi globalizacije vode porodicu i društvo.
JEDNORODITELJSKE PORODICE I MALOLETNIČKA DELINKVENCIJA
Authors: Vasiljević-Prodanović Danica , Kovačević Milica
Published: April 2022

Promene koje se dešavaju u savremenom društvu nisu zaobišle ni porodicu, kao primarnu društvenu grupu. Prema statističkim podacima, tradicionalna porodica u nekim delovima sveta praktično iščezava i ustupa mesto drugim oblicima porodične strukture. Od poslednje četvrtine XX veka primetan je porast učešća jednoroditeljskih porodica, kao i povećanje interesovanja istraživača za ispitivanje problematike ove pojave. Jedno od važnih pitanja je povezanost ovakvog oblika strukture porodice sa maloletničkom delinkvencijom, što čini i predmet ovog rada. Cilj rada je ukazivanje na značaj ispitivanja porodičnih faktora rizika delinkvencije, sa posebnim osvrtom na specifičnosti jednoroditeljskih porodica.
Predictors of Counseling Self-Efficacy: Examining Counselor Trainees' Perception of Supervisory Interaction Style
Authors: Doshi Poonam V. , Ward Alfred W. , Robak Rostyslaw W.
Published: April 2022

The present research examined the relationship between perceived supervisory autonomy support and counseling self-efficacy (CSE) of counselor trainees. We explored whether this relationship was mediated by autonomous work motivation using the framework of self-determination theory (SDT; Ryan & Deci, 2017) . Participants were master’s level mental health counseling interns (n = 182) enrolled in field internships. Mediational analyses showed that autonomous work motivation partially mediated the relationship between perceived autonomy support from supervisor and counselor trainees’ CSE. Results underscore the importance of adopting autonomy-supportive styles of clinical supervision for enhancing counselor trainees’ counseling self-efficacy. What is the public significance of this article?: This study suggests that when clinical supervisors provide an environment that supports counselor trainees’ autonomy, trainees experience increased autonomous motivation, which further enhances their counseling self-efficacy.
Determining Cross-Cultural Mentorship Readiness in Counselor Education and Supervision Programs
Authors: Vernam Jody , Paulson Brian , Falkenstien Bridger D. , Bohecker Lynn , Edwards Nivischi
Published: April 2022

Counselor Education and Supervision (CES) faculty are challenged to include cross-cultural mentorship within CES programs. Successfully implementing cross-cultural mentoring in CES programs requires assessing institutional and CES program readiness and identifying successful strategies. This article outlines a proposed framework to evaluate requisites for cross-cultural mentorship across levels of institutions of higher education and provides strategies to help CES faculty successfully engage and sustain cross-cultural mentorship. What is the public significance of this article? Society and educational programs continue to grow in cultural, racial, and ethnic diversity. As a result, counselor education programs and the systems within which they function will need to adapt to meet the needs of a diverse population of professional counselors, students, and counselor educators. This article enriches the ongoing dialogue on competent cross-cultural mentorship within counselor education programs across various system levels.
A dynamic clamp protocol to artificially modify cell capacitance
Authors: Pfeiffer Paul , Barreda Tomás Federico José , Wu Jiameng , Schleimer Jan-Hendrik , Vida Imre , Schreiber Susanne
Published: April 2022

Dynamics of excitable cells and networks depend on the membrane time constant, set by membrane resistance and capacitance. Whereas pharmacological and genetic manipulations of ionic conductances of excitable membranes are routine in electrophysiology, experimental control over capacitance remains a challenge. Here, we present capacitance clamp, an approach that allows electrophysiologists to mimic a modified capacitance in biological neurons via an unconventional application of the dynamic clamp technique. We first demonstrate the feasibility to quantitatively modulate capacitance in a mathematical neuron model and then confirm the functionality of capacitance clamp in in vitro experiments in granule cells of rodent dentate gyrus with up to threefold virtual capacitance changes. Clamping of capacitance thus constitutes a novel technique to probe and decipher mechanisms of neuronal signaling in ways that were so far inaccessible to experimental electrophysiology.
Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series
Authors: Maroo Vandana , Mukherjee Sanghamitra , Barui Gopinath , Mahata Manisha
Published: April 2022

Soft tissue tumours arise from the mesenchymal tissues of different origin like adipocytic, smooth muscles, skeletal muscle, fibroblastic/ myofibroblastic, fibrohistiocytic, pericytic, vascular, osteo-cartilagineous or even unknown. Its diagnosis depends on the age of the patient and site of presentation but sometimes they may present at unusual sites. Some of the tumours have overlapping histomorphological features which results in a list of differential diagnosis. Therefore, immunohistochemistry and molecular genetics play an important role for definite diagnosis. French Federation of Cancer Centers Sarcoma Group System (FNCLCC) based on necrosis, tumour grading and tumour differentiation is commonly used for grading of the sarcomas to assess the treatment response and prognosis of the patient. Hereby, authors present a series of nine cases of soft issue tumours, comprising five cases of synovial sarcomas and one each of dedifferentiated liposarcoma, rhabdomyosarcoma, epithelioid angiosarcoma and Well Differentiated Liposarcoma (WDLS). Few cases are located at unusual anatomical sites; hence, they should be kept in mind as differential diagnosis. Immunohistochemistry has played an important role for confirmation of diagnosis of synovial sarcomas and angiosarcoma.
A DINÂMICA DE MOVIMENTO DO PENSAMENTO MATEMÁTICO EM PERSPECTIVA NOS TRÊS MUNDOS DA MATEMÁTICA: O CASO HIPOTÉTICO DO TEOREMA DE PITÁGORAS NO ENSINO FUNDAMENTAL
Authors: Polegatti Geraldo Aparecido , Savioli Angela Marta Pereira das Dores , Leivas José Carlos Pinto
Published: April 2022

Neste trabalho tem-se o objetivo de apresentar a dinâmica de movimento do pensamento matemático em perspectiva no quadro teórico dos Três Mundos da Matemática de David Tall: o Mundo Corporificado, como o cenário dos sentidos e das percepções agindo em objetos matemáticos físicos ou mentais; o Mundo Simbólico, que promove as manipulações simbólicas e o desenvolvimento da linguagem matemática; e o Mundo Formal, que refina e descreve o pensamento matemático por meio de axiomas, teoremas e prova matemática. Considera-se o aprimoramento do conhecimento matemático por intermédio de três tipos de agir e por três modos de abstrair, matematicamente, no transcorrer da jornada cognitiva de cada participante em procedimentos educacionais da Matemática. Trata-se de uma pesquisa de cunho bibliográfico a partir de leituras de textos e reflexões teóricas. Propõe-se uma síntese do referido quadro teórico, que serve como guia para processos de ensino e de aprendizagem da Matemática.
FORMAÇÃO CONTINUADA PARA EDUCADORES DOS ANOS INICIAIS DO ENSINO FUNDAMENTAL: A BNCC E A BUSCA DA AUTONOMIA DOCENTE PARA CONSTRUIR OS CURRÍCULOS DE CIÊNCIAS
Authors: Rodrigues Marco Aurélio Torres , Massoni Neusa Teresinha
Published: April 2022

Este trabalho apresenta um estudo que é parte de uma pesquisa mais abrangente que pretende acompanhar o processo de implantação, problematização da Base Nacional Comum Curricular (BNCC) sobre novas exigências na disciplina de Ciências para Anos Iniciais do Ensino Fundamental, bem como a formação continuada de um grupo de professores da rede do município de Santana do Livramento – RS. Norteados pela questão “Que caminhos uma formação continuada, voltada a educadoras e educadores que atuam nos Anos Iniciais do EF, deve trilhar com o intuito de auxiliá-los a dar conta desse novo mecanismo burocrático e normativo, a BNCC, fomentando a (re)construção de seus currículos de Ciências, a partir da promoção da autonomia docente em busca do desenvolvimento de um professor reflexivo-crítico (CONTRERAS, 2002)?” delineamos uma investigação em dois estudos. Apresentamos aqui etapas e alguns resultados do Estudo I, enquanto pesquisa qualitativa, na modalidade pesquisa-ação.
ENSINO TECNOLÓGICO EM PERSPECTIVA E A COMPREENSÃO ANTROPOLÓGICA DE TECNOLOGIA E TÉCNICA
Authors: Gonçalves Carmen Érica Lima de Campos , Gonzaga Amarildo Menezes
Published: April 2022

Refletimos, a partir de pesquisa bibliográfica filosófico-pedagógica, o que é Ensino Tecnológico (ET). Expomos os elementos Ensino, Aprendizagem, Educação, Técnica, Tecnologia, como seus constituintes, interrelacionados, com futuro incerto, exceto se os olhamos através do tempo e decidirmos para onde queremos ir como sociedade cientifizada. Concluímos que o momento é de nos posicionarmos e assumirmos identidade própria a fim de ensinar nossos alunos para uma formação holística, um futuro democrático e consciente entre sociedade e habitat, ou se desviamos da essência pedagógica para mirar apenas na Técnica e na Tecnologia, perdendo de vista o humano. Defendemos que Tecnologia é o desenvolvimento da capacidade simbólica do homem, manifesta pela materialização da forma sobre a substância (produções técnicas) e que consciente disso, o humano manifesta-se culturalmente ou, irrefletido, é mero veículo de sua obra. Vemos na alfabetização científica um percurso viável para efetuar essa compreensão de ET.
Problems Faced by the Dairy Farmers in Palakkad District of Kerala, India
Authors: Maria Poulose T. , Veerakumaran G.
Published: April 2022

Aims: The dairy industry in India is instrumental in providing cheap and nutritional food to the vast population of India and also generates huge employment opportunities for people in rural areas. Milk is the largest product from the agriculture and allied sector in India in terms of value at Rs.6.5 lakh crore. It contributes around 26 per cent of total agriculture’s Gross Domestic Product (GDP). The Kerala currently represents the twelfth largest dairy market in India. The livestock population in Kerala was 38.36 lakh in the year of 2019 [1]. Dairying is a major subsidiary occupation for the farmers of Kerala. But present-day dairying is faced with a number of challenges. The study was conducted to explore various constraints associated with dairy farming as perceived by the farmers.

Objective: To identify the problems faced by dairy farmers in Palakkad district of Kerala.

Methodology: The primary data for this study were collected using a structured interview schedule from 200 active dairy farmer respondents from four selected dairy co-operatives in the Palakkad district.

Results: The temperature variation was the major factor behind the milk production problems. Because Kerala's highest temperature was always recorded in the Palakkad district. But none of the dairy farmers were facing difficulties with milk procurement. All of them were satisfied with the procurement facilities and arrangements. Low accessibility to veterinary services and a lack of sufficient labour were the main problems faced by the selected dairy farmers. Out of 200 dairy farmers, none of them were affected by the floods of 2018 and 2019. The quantity of milk procured by the dairy co-operative society, transportation, profit from the sale of milk, and labour services were mainly affected due to the COVID 19 pandemic. The lack of availability of schemes and support is one of the main problems faced by the respondents. Lack of knowledge about banking services and functions related to subsidies was also one of the problems that existed among them.

Conclusion: From the study, it became evident that dairy farming activities in Kerala, though growing are crippled by a range of problems. The appointment of a trained Artificial insemination, Veterinary First Aid worker, creation of labour groups and continuous monitoring of the progress of schemes and services can solve the problems faced by dairy farmers up to a limit. Finally, this will result in the widening of our country's dairy sector.
The effects of Adopting Technological Innovations on Rice Value Chain Actors in Cameroon
Authors: Ngochembo Gaston Gwemelang , Azibo Balgah Roland , Fru Fonteh Mathias
Published: April 2022

The outcomes of adopting technological innovations remain debatable, in spite of its importance. With multiple innovations available in the sector, not all adopters’ benefit at same the magnitude. The majority of agricultural technology adoption studies analyze adoption effects on a single actor, often neglecting other actors on the value chain; limiting knowledge of adoption rates and their effects on entire value chains. Studying adoption choices and effects among multiple actors on the value chain can provide novel insights of scientific and policy relevance. This study examines the adoption of innovations by multiple rice value chain actors and adoption effects on actors’ performance in Cameroon. The multi-stage sampling technique was applied to identify and collect data from 800 rice value chain actors, using a structured questionnaire. Descriptive statistics and binary logistic regressions were performed to identify adopted innovations; and their income effects respectively, using Statistical Package for Social Sciences (SPSS) version 25. Female actors (55%) dominated the rice value chain compared to males (45%). Mean rice production per actor was 8,011kg/year, generating a mean income of FCFA (Franc Communauté Financière Africaine) 1,201,650.00 (US$ 2,031.23). The number of adopted innovations varied across value chain actors (farmers:7, millers:8, wholesalers:5, and retailers:4). Overall, 13 of the 21 adopted innovations (~62%) had significant effects on actors’ incomes (P = 0.000). Some innovations (owning mobile phones, mobile money accounts, and engaging in mobile money transfers) were adopted by all actors; however, most adopted innovations were actor-specific; indicating differences in actors’ technology preferences. The most important effect of technology adopted was increased food consumption, reported by 100% of all actors. We contend that food security is a prime motive for adopting rice innovations in the study site. We further recommend active participation of actors along the rice value chain in selecting preferred technologies prior to dissemination, to enhance high adoption rates. Future research should identify why only 38% of available innovations were adopted along the rice value chain in this Cameroonian case study, and which factors influenced the choices of different actors. A retrospect on effects other than income can provide stronger relevance for policies promoting adoption of innovations among rice value chain actors in the study site.
Forecasting of Road Traffic Flow Based on Harris Hawk Optimization and XGBoost
Authors: Zhang Longfeng , Yang Yiqi , Deng Yanqiao , Kang Hao
Published: April 2022

With the development of society and economy, people's living standards are improving day by day. The number of private cars is increasing, and the problem of urban traffic congestion is becoming more and more serious. Short-term traffic flow prediction is crucial to assist intelligent transportation system decision-making, solve congestion problems, and improve road capacity. In order to effectively improve the prediction accuracy and improve the generalization performance of the model, this paper combines extreme gradient boosting (XGBoost) and harris hawk optimization (HHO) to propose a multi-step prediction hybrid model. When building a hybrid model, the hyperparameter selection of the XGBoost model is converted into an optimization problem, and the optimization problem is solved through HHO. The solution to the final optimization problem is the optimal parameter combination of the XGBoost model. In order to verify the performance and competitiveness of the model, this study applies the proposed model to traffic flow prediction together with seven other representative models. The results show that the model has high accuracy and stability in practical applications.
MENJAGA KESEHATAN MENTAL DI KENORMALAN BARU PADA MASA PANDEMI COVID-19
Authors: Andrini Susi , Surasmi Rahayu
Published: April 2022

Sekolah Tinggi Ilmu Komunikasi (Stikom) Inter Studi, yang tergabung antara dosen dan mahasiswa khususnya Mahasiswa Konsentrasi Public Relations angkatan 2018, pada mata kuliah  Corporate Social Responsibility (CSR) and Ethic, mengadakan kegiatan Pengabdian Kepada Masyarakat.  Kegiatan online ini  bertemakan “Re-Set Our Mental Health In New Normal“, dengan Judul, “Menjaga Kesehatan Mental di Kenormalan Baru Pada Masa Pandemi covid-19.” Secara umum pandemik Covid-19, telah menimbulkan tingkat kecemasan yang tinggi di antara banyak penduduk dunia dan sebagian masyarakat Indonesia, yang juga tak luput dari rasa kecemasan ini. Karena rasa cemas ataupun takut (Phobia) yang berlebihan ini dapat  mengganggu aktifitas dan kesehatan mental. Saat ini kita hidup di era “New Normal” atau hidup di masa kenormalan baru, akan tetapi pengaruh pandemi ini masih mempengaruhi kondisi mental sebagian masyarakat. Dikarenakan masa pandemi ini menyebabkan adanya “social distancing” keterbatasan jarak yang tidak memungkinkan adanya melakukan kegiatan secara langsung atau secara offline dengan jumlah banyak orang, maka kegiatan Pengabdian Kepada Masyarakat ini dilakukan secara online. Adapun tujuan dari kegiatan ini adalah untuk memberikan pengetahuan dan pemahaman kepada masyarakat agar dapat menjaga kembali kesehatan mental di masa pandemi Covid-19 baik secara teoritis dan praktiknya dengan melakukan olah pernafasan dalam yoga yang dapat memberikan rasa tenang dan nyaman untuk mengurangi stress. Hasil dari kegiatan ini sangat positif dan pikiran menjadi fresh dan tenang setelah para peserta melakukan yoga. Kegiatan ini  dilaksanakan pada hari Kamis, 16 Juli 2020 dengan jumlah peserta sebanyak 73 peserta yang terdiri dari dosen, mahasiswa dan umum.
Monks, priests and farmers
Authors: Ellis Clare , Ballin Torben Bjarke , Boyle Angela , Cruickshanks Gemma , Haggarty George , Hall Derek , Hamilton Derek , Jones Richard , Krus Anthony , Murdock Kenneth , Ramsay Susan
Published: April 2022

A community research excavation centred on Baliscate on the Isle of Mull (NGR: NM 49677 54068) took place in autumn 2012. The excavation has revealed the existence of a thriving 6th-century agricultural settlement which was either adopted or replaced by a 7th-century Christian community which appears to have been a monastic establishment. The continued ecclesiastical nature of the settlement into the 9th and 10th centuries is attested by the presence of a later enclosure/vallum and a rectangular structure interpreted as a leacht. In the late 11th or early 12th century, a stone and turf bow-ended structure was built which probably functioned as a longhouse or hall. This structure was later used in the 12th century to house a large corn-drying kiln. Although no 11th- or 12th-century structures were identified adjacent to the leacht, occupation deposits were identified. Then, in the late 13th or early 14th century, a wattle and turf structure was built over these deposits and the remains of a seventh- to eighth-century cemetery. This structure burnt down and was rapidly replaced by a new stone and turf structure enclosed by a rectangular stone and turf enclosure. This is tentatively interpreted as an enclosed chapel, but the evidence is contradictory and it may have simply been an enclosed farmstead. Occupation around the site continued in one form or another until the 16th century and thereafter the site was used intermittently. The excavation has highlighted how little we know about the so-called enclosed chapel sites of Argyll and the absence of evidence for the early Christian church.
Ionogel‐Based Membranes for Safe Lithium/Sodium Batteries
Authors: Wang Sen , Jiang Yingjun , Hu Xianluo
Published: April 2022

Alkali (lithium, sodium)‐based second batteries are considered one of the brightest candidates for energy‐storage applications in order to utilize the random and intermittent renewable energy to achieve carbon neutrality. Conventional lithium/sodium batteries containing liquid organic electrolytes are vulnerable to electrolytes leakage and even combustion, which hinders their large‐scale and reliable application. All‐solid‐state electrolytes which are considered to have better safety have been developed in recent years. However, most of them suffer from low ionic conductivity and large interfacial resistance with the electrode. Ionogel‐electrolyte membranes composed of ionic liquids and solid matrices, have attracted much attention because of their nonvolatility, nonflammability, and superior chemical and electrochemical properties. This review focuses on the most recent advances of ionogel electrolytes that sprang up with the emerging demand and progress of safe lithium/sodium batteries. The ionogel‐electrolyte membranes are discussed based on the framework components and preparation methods. Their structure and properties, including ionic conductivity, mechanical strength, electrochemical stabilities, and so on, are demonstrated in combination with their applications. The current challenges and insights on the future development of ionogel electrolytes for advanced safe lithium/sodium batteries are also proposed.
Combining diffusive gradients in thin‐films (DGT) and 31P NMR spectroscopy to determine phosphorus species in soil
Authors: Vogel Christian , Doolette Ashlea , Huang Jianyin
Published: April 2022

The diffusive gradients in thin‐films (DGT) technique shows in many publications a superior correlation to the amount of plant‐available phosphorus (P) in soil. However, this technique cannot give information on the plant‐available P species in soil. Therefore, we combined DGT with solution 31P nuclear magnetic resonance (NMR) spectroscopy. This was achieved by using a modified DGT device in which the diffusive layer had a larger pore size, the binding layer incorporated an adsorption material with a higher capacity, and the device had a larger exposure area. The spectroscopic investigation was undertaken after elution of the deployed DGT binding layer in a NaOH solution. Adsorption tests using solutions of known organic P compounds showed that a sufficient amount of these compounds could be adsorbed on the binding layer in order for them to be analyzed by solution 31P NMR spectroscopy. Furthermore, various intermediates of the hydrolysis of trimetaphosphate in soil could be also analyzed over time.

Core Ideas

We show a promising combination of DGT technique and solution 31P NMR spectroscopy.

This technique combination can identify organic phosphorus species in solutions.

Modified DGT device can analyze the hydrolysis of trimetaphosphate in soil.
Mixed neuroendocrine‐non‐neuroendocrine neoplasms of the ampulla of Vater: A case report and literature review
Authors: Chen Chien‐Hung , Kuo Hsing‐Tao , Sheu Ming‐Jen , Sun Chi‐Shu , Lin Yu‐Min , Win Khin Than , Feng I‐Che
Published: March 2022

Mixed neuroendocrine‐non‐neuroendocrine neoplasms (MiNENs) of the ampulla of Vater are extremely rare. We present a case of a MiNEN of the ampulla of Vater and review the literature related to management and treatment recommendations. A 72‐year‐old woman presented with Charcot's triad for a week. Computed tomography revealed a periampullary tumor. Endoscopic retrograde cholangiopancreatography with internal drainage and sphincterotomy with biopsy revealed mixed adenocarcinoma‐neuroendocrine carcinoma. Ampullary MiNEN with an American Joint Committee on Cancer (8th edition) TNM classification of Stage IIIA T3bN1M0 was diagnosed, and the Whipple procedure was performed. Both components of the tumor were of high grade, each component accounting for approximately 50% of the tumor. FOLFOX (oxaliplatin + de Gramont) was prescribed as adjuvant chemotherapy. No recurrence was noted at the 3‐month follow‐up. Diagnosis of MiNENs through biopsies is challenging, and core biopsies should be suggested when a surgical sample is unavailable. Although heterogeneous, MiNENs are usually highly aggressive neoplasms, contributing to the dissemination of metastases and poor prognosis. In conclusion, radical resection is the optimal treatment choice for almost all potentially curable cases. In addition, treatment strategies for patients with a new diagnosis of MiNENs of the ampulla of Vater should be formulated after discussions in multidisciplinary meetings and should be based on the most aggressive and predominant component in the diagnostic sample.