bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the geographic disparity in quality of care: the case of hospital readmission after acute myocardial infarction in Italy
Authors: Wang Yuxi , Ghislandi Simone , Torbica Aleksandra
Published: September 2020

Unwarranted variation in the quality of care challenges the sustainability of healthcare systems. Especially in decentralised healthcare systems, it is crucial to understand the drivers behind regional differences in hospital qualities such as unplanned readmissions. This paper examines the factors that influence the risk of unplanned hospital readmission and the geographic disparity of readmission rate in Italy. We use hospital discharge data from 2010 to 2015 for patients above 65 years old admitted with Acute Myocardial Infarction. Employing hierarchical models, we identified the patient and hospital-level determinants for unplanned readmission. In line with the literature, the risk of readmission increases with age and being male, while hospitals with higher patient volume and capacity tend to have lower unplanned readmission. In particular, we find that after patient risk-adjustments, there are differential effects of hospitalisation length-of-stay on the probability of readmission across the hospitals that are governed by different payment systems. For hospitals under a prospective payment system, the effect of length-of-stay in reducing the probability of readmission is weaker than hospitals under an ex-post global budget, but the overall readmission rates are the lowest. Moreover, there are substantial geographic variations in readmission rate across Local Health Authority and regions, and these variations of unplanned readmission are explained by differences in hospital length-of-stay and surgical procedures used. Our results demonstrate that differential hospital behaviours can be one of the potential mechanisms that drive geographic quality disparities.
Stick–slip behavior during electrowetting-on-dielectric: polarization and substrate effects
Authors: Reid Russell C. , Merrill Marriner H. , Thomas James P.
Published: September 2020

A novel triple-line stick–slip behavior, manifested by “sawtooth oscillations” of the contact angle (CA), was observed during sessile droplet advance by electrowetting-on-dielectric (EWOD) for DC voltages and during droplet retreat for AC voltages. The onset of stick–slip occurred on polished substrate surfaces when the applied potential approached the EWOD saturation voltage and at lower voltages on rougher surfaces. Stick–slip was reduced at higher AC frequencies (> 1 kHz), not significantly influenced by pH or voltage polarity and did not occur with AC polarization on substrates with a Parylene coating but no hydrophobic top-layer. The different triple-line pinning behaviors under DC and AC polarization are shown to be consistent with heterogeneous wetting associated with immobilization of charged species—referred to as charge trapping—near the triple-line at saturation. These experiments and insights offer a new approach for understanding and addressing EWOD device limitations related to CA saturation and charged species trapping leading to improved performance in micro-/nanofluidic pumps, digital microfluidic chips, and electret devices.

Graphical Abstract
An Experiencer, An Animal or An Object? Erection Salience Decreases Men’s Perceived Agency
Authors: Górska Paulina , Budziszewska Magdalena , Marchlewska Marta , Stefaniak Anna , Malinowska Katarzyna , Kuzawińska Olga
Published: September 2020

Three experiments investigated the influence of penile erection on ascriptions of mental capabilities to men. Drawing on sexual objectification literature and the distinction between agency and experience in mind perception, three competing predictions were formulated. The mind redistribution hypothesis assumed that penile erection would lower agency and heighten experience attributions, the animalistic dehumanization hypothesis predicted the decrease in agency, but not experience, and the literal objectification hypothesis implied the simultaneous decrease in both agency and experience. In Experiment 1 (N = 219; 128 females), erection salience lowered agency, but not experience capabilities ascribed to male targets. Experiment 2 (N = 201, 113 females) replicated the negative effect of erection salience on perceived agency (but not experience) and revealed that erection salience lowered intentions to hire a male target. This effect was explained with the loss of perceived agency. Experiment 3 (N = 203, 98 females) verified the causal relationship between penile erection, agency and hiring intentions. Taken together, these results supported the animalistic dehumanization hypothesis.
Proyecto Promover: Attempts to Roll Out an HIV Prevention and Testing Initiative Within a Mexican Immigrant Community
Authors: Ryerson Espino Susan , Aguado Patricia , Puente Monica , Vergara-Rodriguez Pamela
Published: September 2020

Latinx immigrants and men, in particular, living in the US are disproportionally impacted by HIV. Despite these concerns, there is limited research on the development, implementation, and evaluation of community-based HIV education and HIV testing interventions. The current study describes such efforts within a historic Mexican immigrant enclave in Chicago. A mixed-methods case study was used to describe intervention development, as well as preliminary evaluation data. Community intervention components were refined through early focus groups, asset mapping, community networking and consultation with cultural advisors. We exceeded our activity goals. We were successful in reaching a segment of the population that is often overlooked and remains unaware of HIV and its risks. Incorporating social network approaches could facilitate reaching at-risk community groups. Demonstration projects require more time and resources (fiscal and technical) to develop, refine, evaluate and sustain community-level intervention components.
The Hippocratic Risk: Epidemiology of Suicide in a Sample of Medical Undergraduates
Authors: Tarchi Livio , Moretti Matteo , Osculati Antonio Marco Maria , Politi Pierluigi , Damiani Stefano
Published: September 2020

In spite of the growing awareness on medical students’ mental health in recent years, epidemiologic literature about the topic is scarce, particularly for what concerns suicide. Here, we collected cases of suicides among medical students enrolled at a local University in Italy and compared it to the general population of the same age group. Our sample was collected using records of suicides in the city of Pavia, Italy between the years of 2014 and 2019. This record was cross-referenced with enrolment numbers to the Medical Faculty of the city in order to select cases that involved medical students A time-window of 6 years was chosen for the evaluation. The odds ratio of suicide in medical students in comparison to the general population was of 14.58 (p value at the exact Poisson test <0.001). We then differentiated between native Italians and students from abroad. In this case, an odds ratio of 6.81 was observed (p value at the exact Poisson test 0.011). Our estimated suicide rates exceeded what was previously reported for the general population. We call for a closer attention on mental health in medical students, and an increased effort in collecting objective data on the topic.
Humanistic interpretation and machine learning
Authors: Pääkkönen Juho , Ylikoski Petri
Published: September 2020

This paper investigates how unsupervised machine learning methods might make hermeneutic interpretive text analysis more objective in the social sciences. Through a close examination of the uses of topic modeling—a popular unsupervised approach in the social sciences—it argues that the primary way in which unsupervised learning supports interpretation is by allowing interpreters to discover unanticipated information in larger and more diverse corpora and by improving the transparency of the interpretive process. This view highlights that unsupervised modeling does not eliminate the researchers’ judgments from the process of producing evidence for social scientific theories. The paper shows this by distinguishing between two prevalent attitudes toward topic modeling, i.e., topic realism and topic instrumentalism. Under neither can modeling provide social scientific evidence without the researchers’ interpretive engagement with the original text materials. Thus the unsupervised text analysis cannot improve the objectivity of interpretation by alleviating the problem of underdetermination in interpretive debate. The paper argues that the sense in which unsupervised methods can improve objectivity is by providing researchers with the resources to justify to others that their interpretations are correct. This kind of objectivity seeks to reduce suspicions in collective debate that interpretations are the products of arbitrary processes influenced by the researchers’ idiosyncratic decisions or starting points. The paper discusses this view in relation to alternative approaches to formalizing interpretation and identifies several limitations on what unsupervised learning can be expected to achieve in terms of supporting interpretive work.
Per- and polyfluoroalkyl substances (PFASs) in contaminated coastal marine waters of the Saudi Arabian Red Sea: a baseline study
Authors: Ali Aasim M. , Higgins Christopher P. , Alarif Walied M. , Al-Lihaibi Sultan S. , Ghandourah Mohammed , Kallenborn Roland
Published: September 2020

Per- and polyfluoroalkyl substances (PFASs) are today considered important constituents of the continuously growing substance group of persistent contaminants of emerging environmental concern (PCEC). Here, we report for the first time the concentrations of 12 relevant PFASs in 28 marine water samples from the Saudi Arabian coastal waters of the Red Sea. The sum levels of 12 PFASs (Σ12PFAS) in surface seawater ranged from <LOQ to 956 ngL−1. For the reference background site of this study, Σ12PFAS levels ranged from <LOQ to 10.9 ng/L. The highest PFAS levels have been found in Al-Arbaeen and Al-Shabab, two lagoons continuously receiving treated sewage effluents. PFHxA, PFHxS, and 6:2 FTS were the most prevalent PFASs with relatively high concentrations. Discharge of municipal and industrial wastewaters is considered an important source of PFASs. The pattern of PFASs observed here suggests that the usage of PFAS-containing aqueous film-forming foams (AFFFs) is a potential additional source for these compounds in Al-Arbaeen and Al-Shabab lagoons. However, a systematic elucidation of local PFASs sources is needed. Contamination of the Red Sea waters with PFASs poses a potential imminent risk to the marine environment of the Red Sea and ultimately may even affect the health of human consumers through the consumption of local seafood.
PM2.5 exposure as a risk factor for multiple sclerosis. An ecological study with a Bayesian mapping approach
Authors: Bergamaschi Roberto , Monti Maria Cristina , Trivelli Leonardo , Mallucci Giulia , Gerosa Leonardo , Pisoni Enrico , Montomoli Cristina
Published: September 2020

Some environmental factors are associated with an increased risk of multiple sclerosis (MS). Air pollution could be a main one. This study was conducted to investigate the association of particulate matter 2.5 (PM2.5) concentrations with MS prevalence in the province of Pavia, Italy. The overall MS prevalence in the province of Pavia is 169.4 per 100,000 inhabitants. Spatial ground-level PM2.5gridded data were analysed, by municipality, for the period 2010–2016. Municipalities were grouped by tertiles according to PM2.5concentration. Ecological regression and Bayesian statistics were used to analyse the association between PM2.5concentrations, degree of urbanization, deprivation index and MS risk. MS risk was higher among persons living in areas with an average winter PM2.5concentration above the European annual limit value (25 μg/m3). The Bayesian map revealed sizeable MS high-risk clusters. The study found a relationship between low MS risk and lower PM2.5levels, strengthening the suggestion that air pollution may be one of the environmental risk factors for MS.
The Artistic Expression of Feeling
Authors: Kemp Gary
Published: September 2020

In the past 60 years or so, the philosophical subject of artistic expression has generally been handled as an inquiry into the artistic expression of emotion. In my view this has led to a distortion of the relevant territory, to the artistic expression of feeling’s too often being overlooked. I explicate the emotion-feeling distinction in modern terms (distinguishing mood as well), and urge that the expression of feeling is too central to be waived off as outside the proper philosophical subject of artistic expression. Restricting the discussion to the art of painting (and drawing), I sketch a partial psychological model for the exrtistic expression of feelipression of feeling. Although the feeling-emotion contrast is seldom made clear in their writings, I stress that many, or even most of the eminent pre-1960’s voices in aesthetics and art criticism—Croce, Dewey, Langer, Bosanquet, Berenson and others—would more or less agree that feeling is no less important for expression than emotion, and indeed can be interpreted as anticipating many points that I set forth.
Bringing maker practices to school: tracing discursive and materially mediated aspects of student teams’ collaborative making processes
Authors: Riikonen Sini , Seitamaa-Hakkarainen Pirita , Hakkarainen Kai
Published: September 2020

The present investigation aimed to analyze the collaborative making processes and ways of organizing collaboration processes of five student teams. As a part of regular school work, the seventh-grade students were engaged in the use of traditional and digital fabrication technologies for inventing, designing, and making artifacts. To analyze complex, longitudinal collaborative making processes, we developed the visual Making-Process-Rug video analysis method, which enabled tracing intertwined with social-discursive and materially mediated making processes and zoomed in on the teams’ efforts to organize their collaborative processes. The results indicated that four of the five teams were able to take on multifaceted epistemic and fabrication-related challenges and come up with novel co-inventions. The successful teams’ social-discursive and embodied making actions supported each another. These teams dealt with the complexity of invention challenges by spending a great deal of their time in model making and digital experimentation, and their making process progressed iteratively. The development of adequate co-invention and well-organized collaboration processes appeared to be anchored in the team’s shared epistemic object.
Modular change impact analysis in factory systems
Authors: Bauer Harald , Haase Paul , Sippl Fabian , Ramakrishnan Robert , Schilp Johannes , Reinhart Gunther
Published: September 2020

Shorter product innovation cycles, high variant products, and demand fluctuation, as well as equipment life cycles and technology life cycles force manufacturing companies to regularly change their manufacturing system. In order to address this challenge, an efficient and structured change management is required. As change causes and factory elements are connected via a complex network of relations and flows, an essential step in change management is the evaluation of considered adjustments with regard to their effects on the current production system. Depending on the context of the application, change impact analysis must process specific inputs and deliver different results. Current approaches, however, each focus only on selected aspects of the versatility of change effects. To address this challenge, this paper presents a modular approach for the individual design of change impact analysis.
A new design approach for customised medical devices realized by additive manufacturing
Authors: Ricotta V. , Campbell R. I. , Ingrassia T. , Nigrelli V.
Published: September 2020

The aim of this work is the design of a new customised elbow orthosis completely realized by Additive Manufacturing and the development of generative algorithms for parametric modelling and creation of 3D patterns to be adapted to the CAD model. This work describes a method to perfect the design of a custom elbow orthosis. A reverse engineering approach has been used to digitalize the patient’s arm and the subsequent CAD modelling of the structure of the custom elbow orthosis has been performed. In particular, two algorithms have been implemented for the creation of 3D patterns and Voronoi tessellations. Subsequently, FEM analyses have been carried out to validate the design. Finally, a prototype of the elbow orthosis with Voronoi tessellation has been realized by means of the SLS technology. The results obtained have demonstrated that the implemented algorithm solved the problems found during CAD modelling with conventional software. Furthermore, the results of FEM analyses have validated the design choices. All this allowed realizing the prototype by AM technologies without problems. Moreover, the new proposed modelling approaches allows creating, in an interactive way, patterns on complex surfaces. The results of this research activity present innovative elements of originality in the CAD modelling sector, which can contribute to solving problems related to the modelling for Additive Manufacturing. Furthermore, another innovative characteristic of the device is the use of torsion springs that simulate the action of physiotherapists during exercises for patient rehabilitation.
Antibodies Against Hepatitis E Virus (HEV) in European Moose and White-Tailed Deer in Finland
Authors: Loikkanen Emil , Oristo Satu , Hämäläinen Natalia , Jokelainen Pikka , Kantala Tuija , Sukura Antti , Maunula Leena
Published: September 2020

The main animal reservoirs of zoonotic hepatitis E virus (HEV) are domestic pigs and wild boars, but HEV also infects cervids. In this study, we estimated the prevalence of HEV in Finnish cervid species that are commonly hunted for human consumption. We investigated sera from 342 European moose (Alces alces), 70 white-tailed deer (Odocoileus virginianus), and 12 European roe deer (Capreolus capreolus). The samples had been collected from legally hunted animals from different districts of Finland during 2008–2009. We analysed the samples for total anti-HEV antibodies using a double-sandwich ELISA assay. Seropositive sera were analysed with RT-qPCR for HEV RNA. HEV seroprevalence was 9.1% (31/342) in moose and 1.4% (1/70) in white-tailed deer. None of the European roe deer were HEV seropositive (0/12). No HEV RNA was detected from samples of seropositive animals. HEV seropositive moose were detected in all districts. Statistically, HEV seroprevalence in moose was significantly higher (p < 0.05) in the North-East area compared to the South-West area. The highest HEV seroprevalence (20.0%) in district level was more than six times higher than the lowest (3.1%). We demonstrated the presence of total anti-HEV antibodies in European moose and white-tailed deer in Finland. Our results suggest that HEV is circulating among the moose population. Infections may occur also in white-tailed deer. We were the first to report a HEV seropositive white-tailed deer from Europe. Further studies are needed to demonstrate the HEV genotypes in cervids in Finland and to evaluate the importance of the findings in relation to food safety.
The Life and Death and Consequences of Canals and Spoil Banks in Salt Marshes
Authors: Turner R. Eugene , Swenson Erick M.
Published: September 2020

We describe the consequence and demise of levees (spoil banks) built from dredging canals in Louisiana salt marshes using morphometric measurements made over 30 years, soil collections on the spoil bank and in the salt marshes behind, and complementary observations from other areas. These measurements were used to determine the temporal bounds of how long spoil banks last and if salt marsh soils remaining in salt marshes are affected. If the rates of changes in spoil bank morphology continue, then the estimated life time of the shrub-tree vegetation at a representative spoil bank is 81 years, the spoil bank width is 89 years, and the dredged channel will erode to the center of the spoil bank after 118 years. The soils in marshes behind the spoil bank have a higher bulk density than in reference marshes, accumulate more mineral matter per year, have lower root mass and are weaker. These observations are compatible with measurements of spoil bank width, vegetative cover and soil compaction, and the conversion from wetland to open water on a coastwide scale.
Comparing alternative estimation methods of a public goods game
Authors: Kent Danielle
Published: September 2020

This paper empirically compares the use of straightforward verses more complex methods to estimate public goods game data. Five different estimation methods were compared holding the dependent and explanatory variables constant. The models were evaluated using a large out-of-sample cross-country public goods game data set. The ordered probit and tobit random-effects models yielded lower p values compared to more straightforward models: ordinary least squares, fixed and random effects. However, the more complex models also had a greater predictive bias. The straightforward models performed better than expected. Despite their limitations, they produced unbiased predictions for both the in-sample and out-of-sample data.
Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being
Authors: Pesic Milica , Egamberdieva Dilfuza , Kolodziejczyk Bartlomiej , Elsässer Simon J. , Neergheen Vidushi S. , Kagansky Alexander
Published: September 2020

This paper aims to help policy makers with a characterization of the intrinsic value of biodiversity and its role as a critical foundation for sustainable development, human health, and well-being. Our objective is to highlight the urgent need to overcome economic, disciplinary, national, cultural, and regional barriers, in order to work out innovative measures to create a sustainable future and prevent the mutual extinction of humans and other species. We emphasize the pervasive neglect paid to the cross-dependency of planetary health, the health of individual human beings and other species. It is critical that social and natural sciences are taken into account as key contributors to forming policies related to biodiversity, conservation, and health management. We are reaching the target date of Nagoya treaty signatories to have accomplished measures to prevent biodiversity loss, providing a unique opportunity for policy makers to make necessary adjustments and refocus targets for the next decade. We propose recommendations for policy makers to explore novel avenues to halt the accelerated global loss of biodiversity. Beyond the critical ecological functions biodiversity performs, its enormous untapped the repertoire of natural molecular diversity is needed for solving accelerating global healthcare challenges.
Diagnostic Impact of Cerebrospinal Fluid Biomarkers in Atypical Dementias in Canada
Authors: van den Brink Sophie E.M. , El Amrani Laïla , Therriault Joseph , Gauthier Serge , Rosa-Neto Pedro , Vitali Paolo
Published: September 2020

Background:

In Canada, standard dementia workup consists of clinical, neurological, and cognitive evaluation, as well as structural brain imaging. For atypical dementia presentations, additional FDG-PET brain imaging is recommended. Cerebrospinal fluid (CSF) biomarkers have recently been proposed as the gold standard for in vivo detection of Alzheimer’s disease (AD) pathophysiology (NIA-AA research framework, 2018). As clinical implementation of CSF assessment is still limited in Canada, the present study assessed its impact on diagnostic accuracy in atypical neurodegenerative disorders in the clinical practice.

Methods:

This retrospective clinical chart review included patients with cognitive complaints who underwent lumbar puncture (LP) in addition to the standard diagnostic workup. CSF analysis determined the presence of biological AD based on reduced amyloid-β42-to-total-tau index (ATI) and increased phosphorylated-tau (p-tau) levels. CSF-based diagnoses were compared to standard workup and FDG-PET-based diagnoses.

Results:

A total of 28 patients with atypical dementia presentations were included in the present study after evaluation for cognitive complaints at a specialized dementia clinic between November 2017 and July 2019. CSF analysis changed or better specified the initial clinical diagnosis in 43.0% of cases (alternative diagnosis revealed in 25% and excluded in 18%). In patients with additional FDG-PET imaging (n= 23), FDG-PET and CSF-based diagnosis did not correspond in 35% of patients, even though FDG-PET appeared to increase diagnostic accuracy compared to the initial clinical diagnosis.

Conclusion:

CSF biomarkers improved diagnostic accuracy in atypical cognitively-impaired patients beyond standard workup and FDG-PET imaging. These results support CSF analysis implementation for atypical dementias in Canada, in addition to the standard diagnostic workup.
Data-driven surrogate modeling and benchmarking for process equipment
Authors: Gonçalves Gabriel F. N. , Batchvarov Assen , Liu Yuyi , Liu Yuxin , Mason Lachlan R. , Pan Indranil , Matar Omar K.
Published: September 2020

In chemical process engineering, surrogate models of complex systems are often necessary for tasks of domain exploration, sensitivity analysis of the design parameters, and optimization. A suite of computational fluid dynamics (CFD) simulations geared toward chemical process equipment modeling has been developed and validated with experimental results from the literature. Various regression-based active learning strategies are explored with these CFD simulators in-the-loop under the constraints of a limited function evaluation budget. Specifically, five different sampling strategies and five regression techniques are compared, considering a set of four test cases of industrial significance and varying complexity. Gaussian process regression was observed to have a consistently good performance for these applications. The present quantitative study outlines the pros and cons of the different available techniques and highlights the best practices for their adoption. The test cases and tools are available with an open-source license to ensure reproducibility and engage the wider research community in contributing to both the CFD models and developing and benchmarking new improved algorithms tailored to this field.
The Crumble in the Jungle: The London Financial Press and the Boom-and-Bust Cycles of the Ashanti Goldfields Corporation, 1895–1914
Authors: RÖNNBÄCK KLAS , BROBERG OSKAR
Published: September 2020

In this article, we study the role that media plays during a speculative bubble on an emerging market, and in particular the London financial press’s relation to the West African mining bubble of the early twentieth century. The focus is on the leading company in this sector at the time, Ashanti Goldfields Corporation. The London financial press lacked access to independent, reliable information on the ground, so it often failed to provide readers with relevant factual information. In some instances, the press might have even fueled the speculative cycles through the reporting it provided.
DIMENSION INEQUALITY FOR A DEFINABLY COMPLETE UNIFORMLY LOCALLY O-MINIMAL STRUCTURE OF THE SECOND KIND
Authors: FUJITA MASATO
Published: September 2020

Consider a definably complete uniformly locally o-minimal expansion of the second kind of a densely linearly ordered abelian group. Let $f:X \rightarrow R^n$ be a definable map, where X is a definable set and R is the universe of the structure. We demonstrate the inequality $\dim (f(X)) \leq \dim (X)$ in this paper. As a corollary, we get that the set of the points at which f is discontinuous is of dimension smaller than $\dim (X)$. We also show that the structure is definably Baire in the course of the proof of the inequality.
IDENTITY CRISIS BETWEEN SUPERCOMPACTNESS AND VǑPENKA’S PRINCIPLE
Authors: HAYUT YAIR , MAGIDOR MENACHEM , POVEDA ALEJANDRO
Published: September 2020

In this paper we study the notion of
$C^{(n)}$
-supercompactness introduced by Bagaria in [3] and prove the identity crises phenomenon for such class. Specifically, we show that consistently the least supercompact is strictly below the least
$C^{(1)}$
-supercompact but also that the least supercompact is
$C^{(1)}$
-supercompact (and even
$C^{(n)}$
-supercompact). Furthermore, we prove that under suitable hypothesis the ultimate identity crises is also possible. These results solve several questions posed by Bagaria and Tsaprounis.
The response of water column and sedimentary environments to the advent of the Messinian salinity crisis: insights from an onshore deep-water section (Govone, NW Italy)
Authors: Sabino Mathia , Dela Pierre Francesco , Natalicchio Marcello , Birgel Daniel , Gier Susanne , Peckmann Jörn
Published: September 2020

During Messinian time, the Mediterranean underwent hydrological modifications culminating 5.97 Ma ago with the Messinian salinity crisis (MSC). Evaporite deposition and alleged annihilation of most marine eukaryotes were taken as evidence of the establishment of basin-wide hypersalinity followed by desiccation. However, the palaeoenvironmental conditions during the MSC are still a matter of debate, chiefly because most of its sedimentary record is buried below the abyssal plains of the present-day Mediterranean Sea. To shed light on environmental change at the advent and during the early phase of the MSC, we investigated the Govone section from the Piedmont Basin (NW Italy) using a multidisciplinary approach (organic geochemical, petrographic, and carbon and oxygen stable isotope analyses). The Govone section archives the onset of the crisis in a succession of organic-rich shales and dolomite-rich marls. The MSC part of the succession represents the deep-water equivalent of sulphate evaporites deposited at the basin margins during the first phase of the crisis. Our study reveals that the onset of the MSC was marked by the intensification of water-column stratification, rather than the establishment of widespread hypersaline conditions. A chemocline divided the water column into an oxygen-depleted, denser and more saline bottom layer and an oxygenated, upper seawater layer influenced by freshwater inflow. Vertical oscillations of the chemocline controlled the stratigraphic architecture of the sediments pertaining to the first stage of the MSC. Accordingly, temporal and spatial changes of water masses with different redox chemistries must be considered when interpreting the MSC event.
Shareholder Protection: A Comparative Review of the Corporate Legal / Regulatory Regimes in the UK and Nigeria
Authors: Ojogbo Samuel E , Ezechukwu Nwanneka V
Published: September 2020

Foreign investment is a major source of the capital that Nigeria and other developing markets need to promote economic activities and drive economic development. While profit mainly drives the decision to invest abroad, such decisions are also influenced by the safety of any actual investments made. Thus, investors are interested in the laws and regulations that offer them protection against corporate insider opportunism. In Nigeria, the relationship between corporate actors is mainly regulated by the Companies and Allied Matters Act (CAMA). This article investigates the corporate legal and regulatory protection for corporate shareholders in Nigeria and the UK. Comparing the corporate regulatory regime in the two jurisdictions, this article argues that the identified weaknesses in the Nigerian regulatory framework negatively impact the growth of foreign investment in the country. In view of these weaknesses, the article suggests a major review of CAMA and other regulatory instruments with a view to addressing the protection of small investors and “outsiders”, such as foreign investors.
Combining ability and testcross performance of low N tolerant intermediate maize inbred lines under low soil nitrogen and optimal environments
Authors: Ribeiro P.F. , Badu Apraku B. , Gracen V. , Danquah E.Y. , Afriyie-Debrah C. , Obeng-Dankwa K. , Toyinbo J.O.
Published: September 2020

Low soil nitrogen (low N) threatens maize production in sub-Sahara Africa (SSA). We examined the mode of gene action conditioning grain yield of intermediate maturing inbreds and evaluated lines in hybrid combinations for high yield, stability and tolerance to low N. Thirty-two sets of inbreds were crossed to three elite testers (87036, 1368 and 9071) to generate 96 F1 hybrids. The testcrosses plus four hybrid checks were evaluated under low (30 kg/ha) and high (90 kg/ha) N environments at three locations for 2 years in Ghana. Significant general combining ability (GCA) and specific combining ability (SCA) effects were detected for grain yield and most measured traits across test environments, indicating that both additive and non-additive gene action governed the inheritance of the traits. GCA effects were greater than SCA effects, indicating that most traits were controlled predominantly by additive gene action and that inbreds with positive significant GCA effects for grain yield and other traits would contribute favourable alleles to progenies across environments. Hybrid CZL 0001 × 9071 possessed high GY, increased EPP, desirable EHT and PLHT and was the highest yielding under each of two research conditions. Significant genetic correlations were observed between GY and PLHT, EPP, EHT, CA and PA implying that improvement of these traits would lead to significant gains in grain yield under low-N conditions. Hybrids CLWN 247 × 9071, ZM523B-29-2-1-1-B*6 × 9071, TZD II 68 × 1368 and P43SCRq Fs100-1-1-8 × 9071 were high-yielding, stable and low-N tolerant and should be tested on-farm and commercialized.
Portfolio Choice: Familiarity, Hedging, and Industry Bias
Authors: Che Xin , Liebenberg Andre P. , Lynch Andrew A.
Published: September 2020

Investors may underdiversify their portfolios by overweighting securities in which they perceive an informational advantage or by underweighting securities to hedge risks outside the portfolio. We investigate underdiversification in institutional portfolio construction by examining the under/overweighting of industries in U.S. property–liability (PL) insurers’ equity portfolios. We find that PL insurers underweight both their own industry and highly correlated industries in their portfolios. This underweighting is larger for PL insurers exposed to higher underwriting risk. Although PL insurers have an informational advantage in investing in their peers, their underwriting risk drives them to underweight stocks in their industry.
‘Sometimes you gotta get out of your comfort zone’: retirement migration and active ageing in Cuenca, Ecuador
Authors: Hayes Matthew
Published: September 2020

The article extends notions of ‘active’ and ‘successful’ ageing by exploring the narratives of ageing in the retirement migration of Canadian and American older adults in Cuenca, Ecuador. The article is based on 83 semi-structured qualitative interviews (11 of which are follow-up interviews), most conducted in the first half of the 2010s. I explore how notions of finite time and imaginaries of a fourth age of decline and death inform the migration decisions and imaginaries of Canadian and American retirement migrants. I argue that their desire to seek self-expansive, new experiences through migration and contact with cultural difference dialogues with an increasingly competitive neoliberal culture of ageing, that emphasises success through activity, youthfulness and consumption. While there are certainly other ideals that help inform North American migration to Ecuador, I argue that these particular ideals illustrate how discourses of ‘active ageing’ have been taken up ‘from below’, by ageing North American adults, many of whom identify with the aspirations of policy and corporate discourses of activity and success, but who find themselves ageing into material conditions that preclude them. Migration to a lower-cost country, like Ecuador, helps them to experience these aspirations more positively, but may have uneven effects on lower-income workers and their ability to remain in place in the communities marketed for this type of migration.
Two Patients: Professional Formation before “Narrative Medicine”
Authors: FINS JOSEPH J.
Published: September 2020

In this essay, the author reflects on his development as a physician by recounting two patient narratives of patients he cared for as a third year medical student. In the process of telling these stories of sickness, the author also provides a window on medical practice in the 1980’s in an academic medicine center and how practices have changed. Decades before what has been dubbed “narrative medicine,” the author learned the power of words to shape relationships and promote professional formation.
Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma
Authors: Wang Xiaoyan , Langer Ellen M. , Daniel Colin J. , Janghorban Mahnaz , Wu Vivian , Wang Xiao-Jing , Sears Rosalie C.
Published: September 2020

cMYC (MYC) is a potent oncoprotein that is subject to post-translational modifications that affect its stability and activity. Here, we show that Serine 62 phosphorylation, which increases MYC stability and oncogenic activity, is elevated while Threonine 58 phosphorylation, which targets MYC for degradation, is decreased in squamous cell carcinoma (SCC). The oncogenic role of MYC in the development of SCC is unclear since studies have shown in normal skin that wild-type MYC overexpression can drive loss of stem cells and epidermal differentiation. To investigate whether and how altered MYC phosphorylation might affect SCC development, progression, and metastasis, we generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis. In the T58A mutant, MYC is stabilized with constitutive S62 phosphorylation. When challenged with DMBA/TPA-mediated carcinogenesis, MYCT58A mice had accelerated development of papillomas, increased conversion to malignant lesions, and increased metastasis as compared to MYCWT mice. In addition, MYCT58A-driven SCC displayed stem cell gene expression not observed with MYCWT, including increased expression of Lgr6, Sox2, and CD34. In support of MYCT58A enhancing stem cell phenotypes, its expression was associated with an increased number of BrdU long-term label-retaining cells, increased CD34 expression in hair follicles, and increased colony formation from neonatal keratinocytes. Together, these results indicate that altering MYC phosphorylation changes its oncogenic activity—instead of diminishing establishment and/or maintenance of epidermal stem cell populations like wild-type MYC, pS62-MYC enhances these populations and, under carcinogenic conditions, pS62-MYC expression results in aggressive tumor phenotypes.
Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway
Authors: Wang Liyan , Bo Xiaotong , Yi Xiaoyuan , Xiao Xuhua , Zheng Qinghua , Ma Lei , Li Bin
Published: September 2020

Increasing evidence indicates that long non-coding RNAs (lncRNAs) are associated with the progression of human cancers. However, the expression level and function of LINC01559 (long intergenic non-protein coding RNA 1559) in gastric cancer (GC) are rarely reported. Here we found that LINC01559 was upregulated in GC tissues based on GEPIA (Gene Expression Profiling Interactive Analysis) and TCGA (The Cancer Genome Atlas) databases. Also, LINC01559 was expressed at a lower level in GC cells than in mesenchymal stem cells (MSCs). In vitro experiments revealed that silencing LINC01559 remarkably hindered GC cell proliferation, migration and stemness. Then, we identified that LINC01559 was transmitted form MSCs to GC cells via the exosomes. Immunofluorescence staining and electron microscope validated the existence of exosomes in GC cells. Mechanistically, LINC01559 sponged miR-1343-3p to upregulate PGK1 (phosphoglycerate kinase 1), therefore activating PI3K/AKT pathway. Moreover, LINC01559 recruited EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) to PTEN (phosphatase and tensin homolog) promoter, inducing the methylation of PTEN promoter and finally resulting in PTEN repression. Of note, LINC01559 targeted both PGK1 and PTEN to promote GC progression by activating PI3K/AKT pathway. Taken together, our study demonstrated that LINC01559 accelerated GC progression via upregulating PGK1 and downregulating PTEN to trigger phosphatidylinositol 3-kinase/AKT serine/threonine kinase (PI3K/AKT) pathway, indicating LINC01559 as a potential biomarker for GC treatment.
Flavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency
Authors: Martínez-Limón Adrían , Calloni Giulia , Ernst Robert , Vabulas R. Martin
Published: September 2020

Tumor cells adapt their metabolism to meet the energetic and anabolic requirements of high proliferation and invasiveness. The metabolic addiction has motivated the development of therapies directed at individual biochemical nodes. However, currently there are few possibilities to target multiple enzymes in tumors simultaneously. Flavin-containing enzymes, ca. 100 proteins in humans, execute key biotransformations in mammalian cells. To expose metabolic addiction, we inactivated a substantial fraction of the flavoproteome in melanoma cells by restricting the supply of the FMN and FAD precursor riboflavin, the vitamin B2. Vitamin B2 deficiency affected stability of many polypeptides and thus resembled the chaperone HSP90 inhibition, the paradigmatic multiple-target approach. In support of this analogy, flavin-depleted proteins increasingly associated with a number of proteostasis network components, as identified by the mass spectrometry analysis of the FAD-free NQO1 aggregates. Proteome-wide analysis of the riboflavin-starved cells revealed a profound inactivation of the mevalonate pathway of cholesterol synthesis, which underlines the manifold cellular vulnerability created by the flavoproteome inactivation. Cell cycle-arrested tumor cells became highly sensitive to alkylating chemotherapy. Our data suggest that the flavoproteome is well suited to design synthetic lethality protocols combining proteostasis manipulation and metabolic reprogramming.
Mutual modulation between surface chemistry and bulk microstructure within secondary particles of nickel-rich layered oxides
Authors: Li Shaofeng , Jiang Zhisen , Han Jiaxiu , Xu Zhengrui , Wang Chenxu , Huang Hai , Yu Chang , Lee Sang-Jun , Pianetta Piero , Ohldag Hendrik , Qiu Jieshan , Lee Jun-Sik , Lin Feng , Zhao Kejie , Liu Yijin
Published: September 2020

Surface lattice reconstruction is commonly observed in nickel-rich layered oxide battery cathode materials, causing unsatisfactory high-voltage cycling performance. However, the interplay of the surface chemistry and the bulk microstructure remains largely unexplored due to the intrinsic structural complexity and the lack of integrated diagnostic tools for a thorough investigation at complementary length scales. Herein, by combining nano-resolution X-ray probes in both soft and hard X-ray regimes, we demonstrate correlative surface chemical mapping and bulk microstructure imaging over a single charged LiNi0.8Mn0.1Co0.1O2 (NMC811) secondary particle. We reveal that the sub-particle regions with more micro cracks are associated with more severe surface degradation. A mechanism of mutual modulation between the surface chemistry and the bulk microstructure is formulated based on our experimental observations and finite element modeling. Such a surface-to-bulk reaction coupling effect is fundamentally important for the design of the next generation battery cathode materials.
A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
Authors: Enotarpi Jacopo , Tontini Marta , Balocchi Cristiana , van der Es Daan , Auberger Ludovic , Balducci Evita , Carboni Filippo , Proietti Daniela , Casini Daniele , Filippov Dmitri V. , Overkleeft Hermen S. , van der Marel Gijsbert A. , Colombo Cinzia , Romano Maria Rosaria , Berti Francesco , Costantino Paolo , Codeé Jeroen D. C. , Lay Luigi , Adamo Roberto
Published: September 2020

Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) consists of (1 → 6)-2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, O-acetylated at position C3 or C4. Glycomimetics appear attractive to overcome the CPS intrinsic lability in physiological media, due to cleavage of the phosphodiester bridge, and to develop a stable vaccine with longer shelf life in liquid formulation. Here, we generate a series of non-acetylated carbaMenA oligomers which are proven more stable than the CPS. An octamer (DP8) inhibits the binding of a MenA specific bactericidal mAb and polyclonal serum to the CPS, and is selected for further in vivo testing. However, its CRM197 conjugate raises murine antibodies towards the non-acetylated CPS backbone, but not the natural acetylated form. Accordingly, random O-acetylation of the DP8 is performed, resulting in a structure (Ac-carbaMenA) showing improved inhibition of anti-MenA CPS antibody binding and, after conjugation to CRM197, eliciting anti-MenA protective murine antibodies, comparably to the vaccine benchmark.
Integrin-alpha-6+ Candidate stem cells are responsible for whole body regeneration in the invertebrate chordate Botrylloides diegensis
Authors: Kassmer Susannah H. , Langenbacher Adam D. , De Tomaso Anthony W.
Published: September 2020

Colonial ascidians are the only chordates able to undergo whole body regeneration (WBR), during which entire new bodies can be regenerated from small fragments of blood vessels. Here, we show that during the early stages of WBR in Botrylloides diegensis, proliferation occurs only in small, blood-borne cells that express integrin-alpha-6 (IA6), pou3 and vasa. WBR cannot proceed when proliferating IA6+ cells are ablated with Mitomycin C, and injection of a single IA6+ Candidate stem cell can rescue WBR after ablation. Lineage tracing using EdU-labeling demonstrates that donor-derived IA6+ Candidate stem cells directly give rise to regenerating tissues. Inhibitors of either Notch or canonical Wnt signaling block WBR and reduce proliferation of IA6+ Candidate stem cells, indicating that these two pathways regulate their activation. In conclusion, we show that IA6+ Candidate stem cells are responsible for whole body regeneration and give rise to regenerating tissues.