bluuebunny/crossref_metadata_2025 huggingface dataset:
Concentrated Solar Radiation (CSR) Assisted Two-step, One-pot Synthesis
of (S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol (Levodropropizine)
Authors: Kudale Pawan , Chikane Santosh , Pinjari Dipak , Chaturbhuj Ganesh
Published: September 2023

Background:

The recent energy shortage has drawn much attention to synthesizing active
pharmaceutical ingredients (API) using green chemistry concepts like renewable energy sources and
solvents. The concentrated solar radiation (CSR) technique has several advantages, including simple,
affordable, energy and time-efficient for synthesizing active pharmaceutical ingredients and new chemical
entities. Here, we successfully developed a two-step, one-pot synthesis of levodropropizine for the
first time using CSR as a clean energy source and in a green solvent.

Objective:

To synthesize levodropropizine using concentrated solar radiations to save energy and improve
yields while maintaining essential properties like chirality and physical properties.

Methods:

Levodropropizine was synthesized in two steps and in one pot method in a glass apparatus
under concentrated solar radiation using a Fresnel lens measuring 20 cm (l) X 20 cm (b). The outcome
was compared with the one obtained from the conventional heating method. X-ray crystallography,
FTIR, NMR, polarimetry, HPLC-MS, chiral HPLC, DSC, and DTA characterized the Levodropropizine
produced by CSR and conventional heating. The product synthesized by CSR was in agreement with
the one synthesized by conventional heating.

Results:

A two step, one pot synthetic protocol for Levodropropizine using concentrated solar radiations
resulted in 87% yield in 38 minutes while conventional heating method took about 6 hours with
77% yield.

Conclusion:

A two-step, one-pot, environmentally friendly, and straightforward approach to synthesizing
Levodropropizine using concentrated solar radiation has been established; this method minimized
the reaction time from 6.08 h. to 38 minutes, saving up to 90.89% of the energy. Different analytical
techniques for physical characterization, such as x-ray crystallography, DSC, DTA, and chemical identity
and purity by FTIR, NMR, Polarimetry, chiral HPLC, and LC-MS, thoroughly characterized Levodropropizine
synthesized by CSR.
Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells
Expressing Specific Biomarkers
Authors: Pandey Swaroop Kumar , Parul Mradula , Santhanam Manikandan
Published: September 2023

Cancer biomarkers or tumor-associated antigens (TAA) are the focus area of current research
in cancer biology for diagnosis, prognosis, screening, and targeted treatments. Breast cancer is
the second most common type of cancer, affecting women more than men. Conventional methods and
antibody-targeted therapies are less effective and suffer systemic cytotoxicity, poor tissue sensitivity,
low penetration capacity, and reduced accumulation of the drug in tumor cells that limit its application
and sometimes result in treatment failure. Opting for aptamer-mediated targeted delivery of various
anti-cancer agents (drugs, siRNA, miRNA, shRNA and peptides) could possibly overcome these
limitations by utilizing aptamer as a targeting ligand. The purpose of this article is to review the novel
indicative biomarkers of breast cancer and also describe current applications of aptamer-guided active
targeting systems in breast cancer therapy in vivo and in vitro.
Intratesticular Vascular Architecture Seen by Ultrasound Microvascular
Imaging (MicroV). Illustration of the Testis Vascular Anatomy
Authors: Visalli Carmela , Salamone Ignazio , Mormina Enricomaria , Gaeta Michele
Published: September 2023

The testis is a richly vascularized organ supplied by low-flow thin caliber vessels that are only partially detected by traditional Doppler systems,
such as color and power Doppler.

:

However, in the vascular representation, these techniques determine, albeit to different extents, a cut of the weak vessels due to the necessary
application of wall filters that cut the disturbing frequencies responsible for artifacts generated by pulsations of the vascular walls and surrounding
tissues.

:

These filters cut a specific range of disturbing frequencies, regardless of whether they may be generated by low-flow vessels.

:

Recently, a new technology, called Ultrasound Microvascular Imaging (MicroV) has been developed, which is particularly sensitive to slow flows.
This new mode is based on new algorithms capable of better selecting the low frequencies according to the source of origin and cutting only the
disturbing ones, saving the frequencies originating from really weak flows.

:

When Ultrasound microvascular imaging is used, the vascular map is more detailed and composed of macro and microvasculature, with more
subdivision branches, facilitating the interpretation of the normal and, consequently, the pathological.

:

This review aims to describe the vascular architecture of the testis with Ultrasound Microvascular Imaging (MicroV) in healthy testis, compared to
traditional color/power Doppler, related to normal anatomy.
Assessment of Diagnostic Performance of Risk Factors Affecting Extraprostatic
Extension: Role of Zonal Level of Prostate Cancer
Authors: Park Seo Young , Jeon Ga Young
Published: September 2023

Objective:

Extraprostatic extension (EPE) serves as a crucial marker of prostate cancer aggressiveness and independently predicts the likelihood of biochemical recurrence (BCR), exhibiting a strong correlation with the histologic severity of EPE. Therefore, this study aimed to investigate the probability of EPE along the zonal level of the prostate by measuring tumor contact length (TCL) using multiparametric magnetic resonance imaging (mpMRI).

Patients and Methods::

Records of 308 patients who had undergone radical prostatectomy (RP) were identified. Tumor levels in the prostate were categorized as apex, mid-gland, and base, after which the correlation between TCL measured using MRI and microscopic EPE on pathologic specimens was evaluated. Univariable and multivariable logistic regression analyses were performed to assess the association among tumor origin, index tumor diameter, and TCL measured using MRI and microscopic EPE in RP specimens.

Results:

Among the 214 patients included, 45 apical cancers (21%), 87 mid-gland cancers (41%), and 82 base cancers (38%) were observed. Pathological reports revealed that 18 (40.0%) apex, 31 (35.6%) mid-gland, and 50 (61.0%) base tumors were pT3a. Multivariable analysis demonstrated that the zonal level of the tumor, especially the base level, was an independent predictive factor for EPE (P < 0.001), and the AUC value of the base tumor was 0.858.

Conclusion:

Prostate cancers arising from the base were more likely to exhibit EPE than those arising from the mid-gland and apex of the prostate gland. Therefore, identifying the origin of the zonal level of prostate cancer may help guide treatment decisions and predict clinical prognosis.
Docking Analysis of Deltamethrin Pesticide with MHC I and MHC II
Molecules to Establish Immunomodulation Effects
Authors: Kumar Anupam , Singh Bhupender , Kumar Deepak , Verma Anil , Wadhwa Pankaj
Published: September 2023

Background:

Deltamethrin is a class II synthetic pyrethroid pesticide extensively used to control pests and vectors in the agriculture sector and health management programme. Due to excessive applications of this pesticide in the environment, it is harming many organisms other than the target organisms. Higher organisms like human beings are also affected by this pesticide because it instigates the impairment of the central nervous system and also distresses the immune system of vertebrates.

Methods:

In the current research study, MHC I and MHC II molecules of human origin have been targeted to evaluate the interaction with deltamethrin molecules by the AutoDock tool to establish the immunomodulatory effect. MHC I receptor molecule is presented on every nucleated cell, and MHC II receptors are located specifically on cell surfaces of antigen-presenting cells. These receptors play a role in cell-mediated and humoral immune responses. The binding affinity of deltamethrin with MHC receptors can affect the immune response, specifically the acquired immunity of an individual.

Results:

Findings of the current research study support that deltamethrin causes the suppression of the immune system by interaction with MHC I and MHC II molecules and may cause the organisms to be more prone towards antigen and disease development.

Conclusion:

The autoDock tool can be utilized to analyse other pesticides’ effects on the immune system and in the drug development process to minimize the toxic effects due to several types of pesticides.
In silico Study of Clinical Prognosis Associated MicroRNAs for Patients
with Metastasis in Clear Cell Renal Carcinoma
Authors: Wijaya Ezra B. , Mekala Venugopala Reddy , Zaenudin Efendi , Ng Ka-Lok
Published: September 2023

Background:

Metastasis involves multiple stages and various genetic and epigenetic alterations.
MicroRNA has been investigated as a biomarker and prognostic tool in various cancer types and
stages. Nevertheless, exploring the role of miRNA in kidney cancer remains a significant challenge,
given the ability of a single miRNA to target multiple genes within biological networks and pathways.

Objective:

This study aims to propose a computational research framework that hypothesizes that a set
of miRNAs functions as key regulators in modulating gene expression networks of kidney cancer survival.

Methods:

We retrieved the NGS data from the TCGA-KIRC extracted from UCSC Xena. A set of
prognostic miRNAs was acquired through multiple Cox regression analyses. We adopted machine
learning approaches to evaluate miRNA prognosis's classification performance between normal, primary
(M0), and metastasis (M1) samples. The molecular mechanism between primary cancer and metastasis
was investigated by identifying the regulatory networks of miRNA's target genes.

Results:

A total of 14 miRNAs were identified as potential prognostic indicators. A combination of
high-expression miRNAs was associated with survival probability. Machine learning achieved an average
accuracy of 95% in distinguishing primary cancer from normal tissue and 79% in predicting the metastasis
from primary tissue. Correlation analysis of miRNA prognostics with target genes unveiled regulatory
network disparities between metastatic and primary tissues.

Conclusion:

This study has identified 14 miRNAs that could potentially serve as vital biomarkers for
diagnosing and prognosing ccRCC. Differential regulatory networks between metastatic and primary
tissues in this study provide the molecular basis for assessment and therapeutic treatment for ccRCC patients.
Prediction of Plant Ubiquitylation Proteins and Sites by Fusing Multiple
Features
Authors: Guan Meng-Yue , Qiu Wang-Ren , Wang Qian-Kun , Xiao Xuan
Published: September 2023

Introduction:

Protein ubiquitylation is an important post-translational modification (PTM), which is considered to be one of the most important processes regulating cell function and various diseases. Therefore, accurate prediction of ubiquitylation proteins and their PTM sites is of great significance for the study of basic biological processes and the development of related drugs. Researchers have developed some large-scale computational methods to predict ubiquitylation sites, but there is still much room for improvement. Much of the research related to ubiquitylation is cross-species while the life pattern is diversified, and the prediction method always shows its specificity in practical application. This study just aims at the issue of plants and has constructed computational methods for identifying ubiquitylation protein and ubiquitylation sites.

Method:

In this work, we constructed two predictive models to identify plant ubiquitylation proteins and sites. First, in the ubiquitylation proteins prediction model, in order to better reflect protein sequence information and obtain better prediction results, the KNN scoring matrix model based on functional domain Gene Ontology (GO) annotation and word embedding model, i.e. Skip-Gram and Continuous Bag of Words (CBOW), are used to extract the features, and the light gradient boosting machine (LGBM) is selected as the ubiquitylation proteins prediction engine.

Results:

As a result, accuracy (ACC), Precision, recall rate (Recall), F1_score and AUC are respectively 85.12%, 80.96%, 72.80%, 76.37% and 0.9193 in the 10-fold cross-validations on independent dataset. In the ubiquitylation sites prediction model, Skip-Gram, CBOW and enhanced amino acid composition (EAAC) feature extraction codes were used to extract protein sequence fragment features, and the predicted results on training and independent test data have also achieved good performance.

Conclusion:

In a word, the comparison results demonstrate that our models have a decided advantage in predicting ubiquitylation proteins and sites, and it may provide useful insights for studying the mechanisms and modulation of ubiquitination pathways
Consumption of Sexually Explicit Media and Sexual Conduct of greater Exposure to HIV/AIDS in Brazilians
Authors: Almeida Priscilla Dantas , de Araújo Telma Maria Evangelista , de Sousa Anderson Reis , Magalhães Rosilane de Lima Brito , de Brito Vieira Chrystiany Plácido , da Costa Valle Andreia Rodrigues Moura , Lopes e Silva-Júnior Fernando , de Sousa Álvaro Francisco Lopes , Amélia Costa Mendes Isabel
Published: September 2023

Introduction:

We aimed to analyze the association between the consumption of sexually explicit media (SEM) in the sexual practices of Brazilians and the exposure to HIV infection.

Methods:

This is an analytical, cross-sectional national study, conducted with 854 participants. Data were collected from September 2021 to January 2022 and analyzed in SPSS.26 software using the Logistic Regression model, with a robust estimator for the covariance matrix.

Results:

In the results we observed that 558 (65.3%) participants revealed the habit of watching SEM; of these, 58.2% saw up to two scenes per day. The increased chances for involvement in sexual practice of greater exposure to HIV were identified in: being male (ORa=1.36 times); having a homosexual, bisexual, asexual, or pansexual sexual orientation (ORa=1.44); habit of watching SEM or erotic art (ORa=1.47); and being under the age of 12 at the first contact with SEM (ORa=2.74). As such, we can observe that the consumption of sexually explicit media is associated with sexual practices of greater exposure to HIV among Brazilians.

Conclusion:

Therefore, the development of public policies and strategies to prevent practices aimed at the consumption of sexually explicit media becomes relevant, starting with the demonstration of HIV prevention strategies during the sex scenes.
Formulation Of Benzoyl Peroxide Microsponge-Based Transdermal Gel For Acne Infection And Its Evaluation
Authors: Raut Samali S. , Singh Neha R. , Rane Bhushan R. , Jain Ashish S.
Published: September 2023

Background:

Benzoyl peroxide is a peroxide with antibacterial, irritating, keratolytic, comedolytic, and anti-inflammatory properties. When benzoyl peroxide is applied topically, it breaks down and releases oxygen, which kills the germs of Propionibacterium acnes. Benzoyl peroxide's irritating impact causes an increase in epithelial cell turnover, which causes the skin to peel and aids in the healing of comedones. Treatment for acne vulgaris involves the use of benzoyl peroxide.

Objective:

The research is aimed at studying the formulation of Microsponge gel preparation of benzoyl peroxide by using Carbopol 934 as a gelling agent and evaluation of microsponge gel formulation for its physicochemical properties.

Methods:

Microsponges of Anti-acne agent benzoyl peroxide drug were prepared by quasi-emulsion method, and in-vitro drug release using a suitable membrane model using a simple diffusion cell.

Result:

Prior to drying, the microsponge was filtered and rinsed using distilled water. Formulation containing benzoyl peroxide and Eudragit RS100 with a ratio of 1:4 showed a high 87.5% drug content and 78.20 % yield. The drug content of the microsponge gel was found to be 84%. Microbiological study on S. aureus was conducted by the cylinder cup method and found good results. The in-vitro diffusion of microsponge formulations was sustained for 8 hours. The drug release rate for Eudragit RS-100 was reported to be 88.87% after 8 hours based on the polymer: drug ratio (4:1).

Conclusion:

The quasi-emulsion solvent diffusion method was used to successfully prepare benzoyl peroxide microsponges using Eudragit RS100, Ethyl Cellulose, and HPMC K4M as polymers. The formulations with the highest medication concentration were made with the porous polymer Eudragit RS100.
Decolourisation of Metal-azo Dyes in Wastewaters by Sodium Peroxodisulphate: A Template for Experimental Investigations
Authors: Cheung Philip C.W. , Williams Daryl R. , Kirk Donald W. , Murphy Pamela J. , Barton Stephen J. , Barker James
Published: September 2023

Background:

It has long been recognized that the presence of azo metal complex dyes and their non-complexed counterparts in wastewaters, which is due to their manufacturing and use in the textile industries, renders natural waterways intensely coloured, and is therefore aesthetically unacceptable. Azo dye moieties are also known to be precursors of human carcinogenicity.

Objective:

This work aimed at the decolourisation of metal-azo dyes present in wastewaters so that pollution of natural bodies of water can be prevented. Decolourisation is indicative of the destruction of the metal-ligand complex, allowing the retrieval of transition metal ions, which are also water contaminants. Fracturing of the azo bond itself minimizes the potential for the carcinogenicity of these dyes.

Methods:

Decolourisation is achieved by the oxidative action of free radicals furnished by Na2S2O8, the sodium salt of peroxodisulphuric acid (Marshall’s acid). Raman spectroscopy characterizes the dye (ligand) known as “Eriochrome Black T (EBT)” by a peak at 1425 cm-1. Dismantling of its molecular structure by peroxodisulphate will lead to decolourisation accompanied by the collapse of the peak. Concomitantly, as EBT ligands fracture and cease to chelate, metallic ions are released, oxidized to a higher oxidation state, and precipitated as insoluble compounds in alkaline media.

Results:

The concentration of metallic ions in the aqueous phase has been found to be substantially reduced. The successfully treated dye solutions are mostly clear and colourless; their Beer-Lambert absorbances are in the range of 0.02 ≤ absorbance ≤ 0.05. The treatment of Ni(II), Co(II) and Fe(II)-EBT solutions is straightforward; the Cu(II) and Cr(III)-EBT solutions require additional treatment to be included in the above absorbance range. The Cr(III)-EBT is the least responsive to treatment. Fracturing of the azo bond is evinced by Raman Spectroscopy.

Conclusion:

A template to investigate the feasibility of decolourisation of metal-complex dye solutions is pioneered and recommended.
A Registry-based Audit of a Current Situation of Clinical Research in
COVID-19 Using Artificial Intelligence Techniques: A Systematic Review
Authors: Thangaraju Pugazhenthan , Sudha TY Sree , Velmurugan Hemasri , Thangaraju Eswaran , Chirumamilla Kaumudi , Chakrabarti Tulika , Chakrabarti Prasun
Published: September 2023

Background:

The term artificial intelligence refers to the use of computers and technology to
replicate intelligent behaviour and critical thinking similar to that of a human being. In COVID-19, artificial intelligence has been widely applied in diagnostics, public health, clinical decision-making, social
control, treatments, vaccine development, monitoring, integration with big data, operation of additional
vital clinical services, and patient management. Hence, we conceptualized this study to evaluate the usage
of artificial intelligence as a tool at the time of the COVID-19 pandemic.

Methods:

From December, 2019, to May, 2022, all clinical trials using AI approaches listed on clinicaltrials.gov and ctri.gov.in were examined and analysed.

Results:

Out of 8072 studies on COVID-19 listed on ClinicalTrials.gov and 674 studies on the CTRI
website, 53 studies were related to AI. Ten (18.9%) of the 53 studies were interventional, while the remaining 43 (81.1%) were observational.

Conclusion:

With limited medical resources and growing healthcare strain, the introduction of AI approaches will increase human efficiency and capacity to combat the COVID-19 pandemic. In this review,
artificial intelligence was proven to be more accurate than human specialists in COVID-19 diagnosis and
medication discovery.
Assessing the impact of the COVID-19 pandemic on the performance of the Vietnam stock exchange: An empirical analysis
Authors: Dat Pham Thanh , Khanh Pham Dan , Minh Vu Duy , Trung Nguyen Thanh
Published: September 2023

The emergence of COVID-19 in Wuhan, China, in December 2019 led to a global crisis with profound implications for public health and the global economy. This study investigates the ramifications of the pandemic on the Vietnam Stock Exchange, recognizing its interconnectedness with global financial markets. Despite the considerable speculation surrounding the pandemic's influence on economic and financial systems worldwide, limited empirical research has been conducted on its specific impact on the Vietnam Stock Exchange. Employing historical data spanning from January 30, 2020, to April 27, 2022, sourced from a secondary dataset, this research empirically explores the performance of the Vietnam Stock Exchange during the COVID-19 pandemic period compared to a normal period. The findings reveal a significant decline in stock returns and heightened volatility during the pandemic, signaling adverse effects on the exchange's performance. Furthermore, the study applies Quadratic GARCH (QGARCH) and Exponential GARCH (EGARCH) models, incorporating a dummy variable, to scrutinize stock returns. The results corroborate the pandemic's negative impact on stock returns in Vietnam. This research underscores the importance of implementing strategic political and economic policies, including maintaining a stable political environment, promoting indigenous enterprises, diversifying the economy, and adopting a flexible exchange rate regime. These measures are recommended to enhance the resilience of the financial market and attract new investors to the Ho Chi Minh Stock Exchange.
Improving Knowledge of Healthy Lifestyle Using WhatsApp Application and Health Screening of Productive Age Population in Pajimatan Hamlet, Imogiri, Bantul
Authors: Hastuti, S.Si, M.Kes, Ph.D Janatin , Rahmawati Neni Trilusiana
Published: September 2023

The prevalence of obesity continuously increase, as are associated comorbidities and healthcare expenses. Early detection, intervention, and effective treatment of obesity are important to improve quality of life and to reduce costs. This Community Practice Program aimed to evaluate health status and provide education about healthy life style of people at productive age in Pajimatan Hamlet, Imogiri, Bantul, Yogyakarta.  Participants were 66 adults (26 men, 40 women) aged 19-64 years living in Pajimatan Hamlet. The program was held on November 2021. Education on healthy life style was done using WhatsApp group. Pre- and post-test were given to the participant before and after the education. Health screening was done by measuring height, weight, waist circumference (WC), blood pressure BP), and fasting blood glucose level. Obesity was determined using body mass index (BMI) and WC. There were significant increase scores before and after education in men (p= 0.017) and women (p< 0.001). Health screening indicated that men were significantly taller (p< 0.001) and heavier (p= 0.009) than women, however, there was no difference in BMI, WC, BP, and fasting blood glucose level (p> 0.05). There were no differences in the distribution of BMI obesity between men and women, however, women with central obesity were higher than men (70% women, 30% women, p= 0.021). Men having prehypertension were higher than women (46.2 vs. 15%), on the other hand, women with hypertension I and II seemed to be higher than men (p= 0.043). The prevalence of type-2 diabetes was slightly greater in women (12.5%) compared with 7.7% in men. In conclusion, the Community Service Program found high prevalence of obesity and hypertension in the population. Education on healthy life style program can help to improve knowledge of the target population.
An Overview of Clean and Healthy Living Behavior Practices in the Islamic Boarding-Based Education (Pondok Pesantren) Environment
Authors: Farhany Fajrul Falah , Amalia Ichlasul , Rachmawati Meyka Budi , Ernia Winda , Rinonce Hanggoro Tri , Kusumawati Happy Indah , Muslichah Rahadyana
Published: September 2023

Clean and Healthy Living Behavior (CHLB) practices in a congregate setting like Pondok Pesantren plays a vital role in maintaining the health of each individual living in. This study aims to provide an overview of student’s (Santri) CHLB practices at the Pondok Pesantren Assalafiyah 2 Mlangi. It is a quantitative study using a descriptive analysis approach conducted in July-September 2022. A non-probability sampling with a total sampling of 848 santri were used. The data were collected using self-administered questionnaires developed on Google Form and imported to Microsoft Excel for further data analysis. Several indicators were assessed, including personal health maintenance, CHLB implementation, and environmental cleanliness. The results showed that the students consume fruit less than 2 timers per day (89.3%), vegetables less than 3 times per day (45.6%), drinking 6-9 glasses of water (18.3%), only 4.2% have routine exercise schedule with the duration more than 120 minutes per week, and only 44.7% students have regular sleep patterns of 6-8 hours per day. The CHLB practices implementation and environmental cleanliness used the indicators of good hand washing practices, regular bathroom and dormitories cleaning, and the overall cleanliness of the Pondok Pesantren achieved good performance which scored around 55.1-64.4%. While 45.8-50% of the students reported an average good scoring for the available cleaning and healthcare facilities. The results of this study will be used to develop recommendations related to the importance of basic personal health education using CLHB practices to promote and prevent disease transmission in congregate facilities. To improve the overall health outcomes of the students, there are some measures that could be taken, including providing training for health cadres, provision of proper healthcare facilities, and developing digital health interventions such as telemedicine applications for further consultation with healthcare professionals.
Collective & Connective Action: Kajian Respons Warganet Terhadap Gerakan #BupatiKlatenMemalukan dalam Pilkada Klaten 2020
Authors: Kriswantoro Thomas
Published: September 2023

Artikel ini membahas gerakan #BupatiKlatenMemalukan dalam konstelasi Pemilihan Kepala Daerah Kabupaten Klaten 2020. Tulisan ini berupaya melihat korelasi antara “connective action” di satu sisi dan “collective action” di sisi lain dalam memahami protes masyarakat dalam Pemilihan Kepala Daerah Kabupaten Klaten di media sosial. Dalam mengambil data, artikel ini menerapkan metode wawancara dan dalam menganalisis masalah memakai metode analisis “big data”. Metode tersebut digunakan untuk mengidentifikasi dan memetakan polarisasi isu, substansi wacana, hingga aktor yang berperan sebagai opinion leader. Kajian dalam artikel ini menemukan bahwa pertama, gerakan media sosial tidak sepenuhnya efektif dalam dalam membingkai gerakan protes karena gerakan #BupatiKlatenMemalukan ini sebatas clicktivism, yaitu gerakan yang hanya sebatas “click” tanpa adanya gerakan fisik, yang cenderung tidak progresif; kedua, gerakan berbasis media membutuhkan penopang, yakni gerakan kolektif secara fisik (offline) dari masyarakat untuk mengubah suatu kebijakan; ketiga clicktivism #BupatiKlatenMemalukan secara garis besar tidak serta-merta mengubah preferensi politik seseorang.
Investigating the Impact of Neuromarketing on Consumer Purchase Intention (Case Study of Sports Goods Customers in Ardabil City)
Authors: Moharramzadeh Mehrdad , Baghi Abbas Naghizadeh , Nobakht Farzad , Mahdavi Akbar
Published: September 2023

The purpose of this research was to investigate the effect of neuromarketing on consumer purchase intention (a case study of sports goods customers in Ardabil city). The current research is applied research in terms of purpose and descriptive-analytical in terms of nature and content. The statistical population of this research includes all private sports clubs and sellers of sports goods in Ardabil city, the sample size was 352 people considering that the statistical population is unlimited and the sampling method was clustered. The measurement tools include neuromarketing questionnaire (Azeimi et al., 2015) and consumer purchase intention questionnaire (Mahdavi, 2015). The content and form validity of the questionnaires were confirmed by the management professors and then Cronbach’s alpha reliability (AVE) was reported as 0.83 for the neuromarketing questionnaire and 0.88 for the consumer purchase intention questionnaire, respectively. The structural equation method was used for analysis using Imus version 23 and SPSS version 19 software. The findings of the research showed that neuromarketing has an effect on the purchase intention of sports goods consumers. Therefore, it can be concluded that the use of neuromarketing can influence the senses and minds of customers and make consumers’ minds ready for repeat purchases.
Artisanal Inland Water Fishing and Challenges of Livelihood Sustainability in Ibi Local Government Area, Taraba State Nigeria
Authors: D. PhD Oruonye, E. , J. Emmanuel, , M., PhD Ahmed, Y. , D. G. Musa,
Published: September 2023

This study examined challenges of livelihood sustainability from artisanal inland water fishing activities in Ibi LGA, Taraba State, Nigeria. Descriptive survey design was adopted. Purposive sampling was used in selecting 406 respondents from 12 communities in 6 political wards of the LGA. Descriptive statistics was used to analyse 401 questionnaires retrieved. Findings of the study reveal decline in daily fish catch from three baskets 10 years ago to only one basket presently. Also, income from fishing has declined from ₦150,000 ($192) monthly 10 years ago to less than ₦50,000 ($64) presently. Factors responsible for decline in fish catch include rising water level, temperature increase, pollution, climate change, seasonality and unsustainable fishing practices. The unsustainable fishing practices include use of chemicals, small size nets and mosquito nets in fishing. The results reveal that fishermen engaged in non-fishing activities, fish farming and construction of fishing ponds along the floodplain as a way of achieving livelihood sustainability. Challenges of livelihood sustainability include seasonality of fishing activities, decline in fish stocks, use of traditional fishing methods and unsustainable fishing practices among others. The study recommend the need to enforce extant laws on fishery protection,  enlightenment campaign, and government support to fishing cooperatives.
Pork Quality Attributes and Eating Characteristics Among Different Premium and Commodity Pork Loin Programs
Authors: Beyer Erin S. , Prill Lauren L. , Rice Emily A. , Drey Lindsey N. , Olson Brittany A. , Gonzalez John M. , Chao Michael D. , Vipham Jessie L. , Zumbaugh Morgan D. , O'Quinn Travis G.
Published: September 2023

Pork branding is a common tool used to differentiate products based on quality to assist consumers in making purchasing decisions. Most pork processers have premium pork programs with different parameters related to color, mar-bling, and other quality factors, though many differences in specific criteria exist among programs. The objective of this study was to assess differences in pork quality and the associated eating experience of different premium and commodity pork loin programs available in the retail market. Loins (n=30/brand) from 7 branded (PRE A, B, C, D, and E) and commodity (COM A and B) programs were acquired and fabricated at 14–15 d post-box date into 2.54-cm chops for visual color, marbling, pH, intramuscular fat, drip loss, purge loss, shear force, and trained sensory panels. Overall, few differences were found among products for most of the quality traits evaluated. One commodity brand, COM B, had higher (P<0.05) loin L* values and chop L* values and had lower chop a* values, visual color scores, pH, and drip loss than other treatments, but it did not differ (P>0.05) in initial juiciness, sustained juiciness, or any tenderness measurement. The only quality measurement that was associated with changes in eating experience was shear force value, with the PRE C product having the highest (P<0.05) Warner-Brazler shear force and slice shear force values and the associated lowest (P<0.05) myofibrillar tenderness and overall tenderness ratings in the sensory panels. There were no differences (P>0.05) among any treatment for initial juiciness, sustained juiciness, and pork flavor intensity. The results from this study indicate that the range of pork quality differences sold domestically among the evaluated premium and commodity programs is minimal and does not result in associated differences in eating experience.
ГЕНЕРАТОРЫ СВЧ С ПРИМЕНЕНИЕМ ФЕРРИТОВЫХ РЕЗОНАТОРОВ. ЧАСТЬ 2
Authors: Геворкян В. , Кочемасов В. , Сафин А.
Published: September 2023

Рассмотрены генераторы СВЧ с применением ферритовых резонаторов. Приведена информация о конструктивных и электрических характеристиках коммерческих ЖИГ-генераторов, выпускаемых различными производителями.
Synthesis of Tungsten Trioxide/Hydroxyapatite (WO3/HAp) Photocatalyst For Methylene Blue Degradation
Authors: Mizar Khalid , Mulyati Sri , Arahman Nasrul
Published: September 2023

Abstract: Dyes have toxic properties and complex chemical structures which become a threat to the ecosystem if it exposes to the environment. A photocatalyst is a semiconductor material that can run a photocatalytic process under UV or visible light to degrade most organic molecules, ideally to H2O and CO2. Tungsten trioxide (WO3) is a visible photocatalyst which could use sunlight irradiation to treat the wastewater pollutant. In this study, WO3 material was hybridized with hydroxyapatite (HAp) through the sol-gel method to degrade methylene blue (MB) synthetic pollutants. The FTIR and SEM-EDX characterization confirmed the presence element of the WO3/HAp hybrid material. The original WO3 and modified WO3/HAp photocatalysts with concentrations of 10, 15, and 20 mg were tested to degrade 15 ppm of 50 ml MB solution under visible light for 4 hours. The highest pollutant degradation was obtained using a 20 mg photocatalyst, which reached the photodegradation efficiency of 73.072% for WO3 and 88.689% for WO3/HAp. The result proved that WO3/HAp hybrid photocatalyst showed higher degradation performance than the unmodified WO3 photocatalyst. The results of this research can be developed for industrial wastewater treatment, including the papermaking, printing and dyeing industries.Abstrak: Zat warna  memiliki sifat beracun dan memiliki struktur kimia  kompleks yang dapat menjadi ancaman bagi ekosistem apabila terpapar ke lingkungan. Fotokatalis heterogen menggunakan semikonduktor yang memicu proses fotokatalitik dengan bantuan sinar UV atau sinar tampak dalam mendegradasi kebanyakan limbah organik, menjadi H2O dan CO2. Tungsten trioksida (WO3) merupakan fotokatalis yang dapat menggunakan cahaya matahari untuk mendegradasi polutan pada air limbah. Pada penelitian ini, WO3 dihibridisasi dengan hidroksiapatit (HAp) melalui metode sol-gel untuk mendegradasi polutan sintetik Methylene Blue (MB). Hasil karakterisasi FTIR dan SEM-EDX mengkonfirmasi unsur-unsur penyusun material  WO3/HAp. Fotokatalis WO3 munri  dan WO3/HAp yang dimodifikasi diuji untuk mendegradasi 15 ppm larutan MB 50 ml di bawah cahaya tampak selama 4 jam dengan konsentrasi 10, 15 dan 20 mg. Degradasi polutan tertinggi diperoleh dengan menggunakan fotokatalis 20 mg yang mencapai efisiensi 73,072% untuk WO3 dan 88,689% untuk WO3/HAp. Hasil tersebut membuktikan bahwa fotokatalis hybrid WO3/HAp menunjukkan kinerja degradasi yang lebih baik daripada fotokatalis WO3 tanpa modifikasi.
Importance of Ahara in Today’s Life with Special Reference to Ayurveda.
Authors: Yewale Dr Swapnali , Yewale Dr Prasad
Published: September 2023

Ayurveda is an eternal science. Among all the vise concepts of Ayurveda, Trayaupsthambha has prime importance as itconsists of three pillars that are Ahara(Diet), Nidra(Sleep), and Brahmacharya (Celibacy). The longevity and happiness of lifedepend upon these three pillars. Each one has its importance; among them, Aharaachieved first position in Trayaupsthambha,which denotes its prime importance in Trayaupsthambha. Hence we must know the Ahara (diet) described in Ayurveda.Consuming a healthy diet in the right way can lead to good health; however, eating food that isn't wholesome can make you sick.Ahara gives the body power, radiance, and Oja; it is essential for longevity and increases mental fortitude. Our ancient seerdescribes some rules regarding diet that every person should follow. If not, then the most beneficial object Ahara will turn into amost harmful object, which can cause various diseases. The healthy physical body and mind together are responsible for health.Our ancient seer, in their commentaries, proves that Ayurveda helps in keeping the equilibrium of all physiological functions ofSharir and Manas via proper Ahara. This article aims to study the importance of the ahara in today's life. To achieve the goal of ahealthy life, the Ahara plays a vital role. This article aims to collect and analyze the literature review of the Sahara andunderstand the dietic rules explained in Ayurveda. This article discussed the significance of Ahara and diseases caused by pooreating habits. If Ahara is not consumed properly, numerous disorders, including the effects of Apathya-Ahara, may be noticed.
Method Development and Validation of Curcuminoids in Curcuma Angustifolia Roxb. By RP-HPLC and Its Antifungal Activity
Authors: P Warrier Pravith , R Badole Madhavi
Published: September 2023

Curcuma angustifolia Roxb., a rhizomatous herb, belongs to the Zingiberaceae family of plants. The species is rich innutrients and is used mostly as a source of starch for Indian dishes and medicines. The published research articles for themeasurable estimation of components in Curcuma angustifolia Roxb. rhizomes are very scarce. The present study aimed to developa quantitative analysis method for estimating the constituents in the methanolic extract of Curcuma angustifolia Roxb. rhizome andto investigate its biological activity. Within the context of this challenge, the current work is a unique effort that recommends ahigh-performance liquid chromatography (HPLC) method for estimating curcuminoids, namely curcumin, demethoxycurcumin,and bis-demethoxycurcumin, present in the methanolic extract of Curcuma angustifolia Roxb. rhizome. A reverse-phase HPLCmethod was developed to estimate curcuminoids in the extract. The method was validated and found to be precise, sensitive,specific, linear, accurate, and robust. The method validation study's findings demonstrated the method's suitability for routine use.The HPLC method was successfully applied to a marketed formulation containing rhizome powder from Curcuma angustifolia Roxb.as one of its constituents. This study investigates the antifungal activity of the methanolic extract in vitro using an agar well diffusionassay method. A minimum inhibitory concentration (MIC) was established, and the antifungal activity was evaluated against Candidaalbicans and Candida glabrata with fluconazole as the standard reference. The development and validation of an HPLC method fortesting curcuminoids in Curcuma angustifolia Roxb. rhizome and the evaluation of rhizome extract antifungal activity are excellentexamples of herbal medicine quality control in its entirety. The in vitro antifungal activity results reaffirm the usage of Curcumaangustifolia Roxb. as a source of antifungal agents. They can lead to the developing of new herbal medicines in the coming days.
It is Along Ways: Global Payment Infrastructure in Movement
Authors:   , Giraldo-Mora Juan Camilo
Published: September 2023

This work reveals movement in infrastructure development through an anomaly in the global payment infrastructure. The anomaly is that while the global payment infrastructure develops without precedent, the infrastructure takes time to develop and does not easily leave anything behind. Based on abduction, the research builds a data corpus of past, present, and future global payment infrastructure, 1973–2030, including accounts of global payment organisations, historical reports, and narrative interviews. By juxtaposing these data with studies on infrastructure and following the work of Heidegger and Bateson, the research reveals movement through what the author terms infrastructural ways. The global payment infrastructure forms and develops because there are infrastructural ways for global payment to be objects, pass as real, and result from action. Granular homogenisation, irreversible validation, and ubiquitous causation are such ways. Moving along, hurtling, swaying, and rippling are the infrastructural ways for global payment to be objects passing as real, pass as real with action, and result from active objects. These findings clarify through movement how the global payment infrastructure develops. In doing so, this work contributes an ontological approach that revisits the predominant assumptions about infrastructure development, which emphasise the persistence and change of infrastructure.
A presença do gótico em Lira dos vinte anos e Noite na taverna, de Álvares de Azevedo
Authors:   , Schonfelder Laura Cavalheiro Vieira
Published: September 2023

Quando consideramos as primeiras manifestações do gótico no Brasil, logo identificamos Manoel Antônio Álvares de Azevedo, escritor e poeta da Segunda Geração do Romantismo Brasileiro, como introdutor dessa literatura na cena local. Este trabalho tem como objetivo identificar os elementos de estética gótica presentes nas obras do autor, tendo como foco a análise dos livros Lira dos Vinte Anos e Noite na Taverna. Este projeto, inserido na linha de pesquisa Literatura do curso de Letras, apresenta-se como pesquisa bibliográfica de abordagem qualitativa com tipo de delineamento revisão de literatura, e baseia-se na análise discursiva de Brait (2006). Para base teórica, fundamenta-se em Candido (1989, 2000), Cunha (1998, 2004), Todorov (1975), dentre outros. Acompanhamos a origem histórica do gótico, o seu desenvolvimento na Europa e sua chegada ao Brasil junto ao chamado romantismo literário. Assim, constatamos a partir da análise de narrativas, personagens e elementos literários, que Álvares de Azevedo é adepto ao gótico em suas obras e vida pessoal.
O desenvolvimento do complexo militar-industrial dos Estados Unidos e sua intensificação nos governos pós-Guerra Fria
Authors:   , Couto Lucas Sewaybrick
Published: September 2023

Este trabalho aborda o complexo militar-industrial dos Estados Unidos, examinando as interações entre o poder político, a indústria de defesa e a formulação de políticas ao longo das administrações de Eisenhower a Trump. O estudo explora a relação estreita entre o governo e a indústria de defesa, analisando como os interesses econômicos influenciam as decisões políticas e a formulação de políticas públicas. Além disso, investiga a evolução histórica do complexo militar-industrial, destacando as mudanças ocorridas ao longo do tempo. O trabalho também examina os programas militares implementados durante as administrações de Obama e Trump, bem como a relação direta desses programas com a indústria de defesa.
The Impact of Modified Cognitive-Behavioral Group Therapy in Social Adjustment Functions of Children with ADHD and Their Parents’ Stress Levels: A Nonrandomized Clinical Trial
Authors: Jiang Xiangyu , Chen Minrong
Published: September 2023

This study aims to investigate the potential of a modified
Cognitive-Behavioral Group Therapy (CBGT) intervention in promoting
social adjustment and reducing parental stress among children exhibiting
symptoms of attention deficit hyperactivity disorder (ADHD). The
research also highlights the mechanisms and advantages of employing
modified CBGT counseling to address negative symptoms associated with
ADHD in children. The study was conducted at Fuzhou Children’s Hospital
of Fujian Province, involving two CBGT counseling sessions held in 2021
and 2022, with a total of 20 pairs of parents and children with ADHD
participating. The assessment utilized measures such as SNAP, Barratt
Impulsivity, and Conners to evaluate changes in the children’s social
adjustment abilities and core/associated ADHD symptoms before and after
CBGT intervention. Additionally, the Parental Stress Index was employed
to gauge the level of stress experienced by the parents. The results
demonstrated that modified CBGT interventions effectively alleviate ADHD
symptoms, enhance parent-child relationships, and reduce parental stress
levels. Consequently, CBGT interventions have shown substantial
improvements in children’s social adjustment abilities and have proven
to be a significant source of relief for parents. The study also
addresses the limitations associated with existing ADHD treatments and
CBGT interventions.
Quantitative and Qualitative Analysis of a Quantum Multisingular Problem by Computational Method and Heatmaps
Authors: George Reny , Alshammari Fahad Sameer , Ghaderi Mehran , Rezapour Shahram
Published: September 2023

The physical phenomena with uncontrollable singularities pose challenges
in solving related differential equations. In this work, we intend to
investigate the quantitative and qualitative aspects of a multi-singular
integro-differential equation with the help of quantum fractional
operators by presenting numerical algorithms. Quantum calculus enables
us to use numerical algorithms and software. The α-
ψ-contraction, a new technique of fixed point theory, plays a
significant role in proving the existence of the solution. To interpret
tables with quantum values quickly and easily, we use heatmaps. We also
presented three numerical examples to illustrate the accuracy and
efficiency of our main results.