bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection on Cell Cancer Using the Deep Transfer Learning and Histogram Based Image Focus Quality Assessment
Authors: Bhuiyan Md Roman , Abdullah Junaidi
Published: September 2022

In recent years, the number of studies using whole-slide imaging (WSIs) of histopathology slides has expanded significantly. For the development and validation of artificial intelligence (AI) systems, glass slides from retrospective cohorts including patient follow-up data have been digitized. It has become crucial to determine that the quality of such resources meets the minimum requirements for the development of AI in the future. The need for automated quality control is one of the obstacles preventing the clinical implementation of digital pathology work processes. As a consequence of the inaccuracy of scanners in determining the focus of the image, the resulting visual blur can render the scanned slide useless. Moreover, when scanned at a resolution of 20× or higher, the resulting picture size of a scanned slide is often enormous. Therefore, for digital pathology to be clinically relevant, computational algorithms must be used to rapidly and reliably measure the picture’s focus quality and decide if an image requires re-scanning. We propose a metric for evaluating the quality of digital pathology images that uses a sum of even-derivative filter bases to generate a human visual-system-like kernel, which is described as the inverse of the lens’ point spread function. This kernel is then used for a digital pathology image to change high-frequency image data degraded by the scanner’s optics and assess the patch-level focus quality. Through several studies, we demonstrate that our technique correlates with ground-truth z-level data better than previous methods, and is computationally efficient. Using deep learning techniques, our suggested system is able to identify positive and negative cancer cells in images. We further expand our technique to create a local slide-level focus quality heatmap, which can be utilized for automated slide quality control, and we illustrate our method’s value in clinical scan quality control by comparing it to subjective slide quality ratings. The proposed method, GoogleNet, VGGNet, and ResNet had accuracy values of 98.5%, 94.5%, 94.00%, and 95.00% respectively.
Influence of Geographical Location of Spirulina (Arthrospira platensis) on the Recovery of Bioactive Compounds Assisted by Pulsed Electric Fields
Authors: Ramon-Mascarell Francesc , Martí-Quijal Francisco J. , Castagnini Juan Manuel , Phimolsiripol Yuthana , Ruksiriwanich Warintorn , Rajoka Muhammad Shahid Riaz , Mehwish Hafiza Mahreen , Barba Francisco J.
Published: September 2022

Spirulina (Arthrospira platensis) has been consumed by humans since ancient times. It is rich in high added-value compounds such as chlorophylls, carotenoids and polyphenols. Pulsed electric fields (PEF) is an innovative non-thermal technique that improves the extraction of bioactive compounds from diverse sources. PEF pre-treatment (3 kV/cm, 100 kJ/kg) combined with supplementary extraction with binary solvents at different times was evaluated to obtain the optimal conditions for extraction. In addition, the results obtained were compared with conventional treatment (without PEF pre-treatment and constant shaking) and different strains of Spirulina from diverse geographical locations. The optimal extraction conditions for recovering the bioactive compounds were obtained after applying PEF treatment combined with the binary mixture EtOH/H2O for 180 min. The recovery of total phenolic content (TPC) (19.76 ± 0.50 mg/g DM (dry matter) and carotenoids (0.50 ± 0.01 mg/g DM) was more efficient in the Spirulina from Spain. On the other hand, there was a higher recovery of chlorophylls in the Spirulina from China. The highest extraction of total antioxidant compounds was in Spirulina from Costa Rica. These results show that PEF, solvents and the condition of growing affect the extraction of antioxidant bioactive compounds from Spirulina. The combination of PEF and EtOH/H2O is a promising technology due to its environmental sustainability.
Exploring the Antioxidant and Bioinsecticidal Activity of Spontaneous Flora Vegetal Extracts for Plant Protection and Prevention of Soil Contamination
Authors: Daraban Gabriel Mihăiță , Rusu Lăcrămioara , Dinica Rodica Mihaela , Roşca Mihaela , Badeanu Marinela , Mihaila Maria Daniela Ionica , Suteu Daniela
Published: September 2022

The purpose of this article was to evaluate the application of different plant extracts with bioinsecticidal action and antioxidant activity for plants and soil protection, by substitution of the application of synthetically formulated pesticides with eco-friendly compounds. In this framework, this research focused on the utilization of plant extracts from the spontaneous flora of Moldova (Romania) as bioinsecticides for the control of field pests of the species Leptinotarsa decemlineata and their antioxidant activity. Plant extracts of oregano (Origanum vulgare), yarrow (Achillea millefolium), wormwood (Artemisia absinthium), and cowslip (Primula veris) were assessed for their antioxidant activity by the microplate spectrophotometric-based method (for polyphenols and flavonoids content and for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger activity) and were characterized by FTIR spectroscopy spectra. To evaluate the bioinsecticidal properties of the plant extracts, the mortality (%) and neuroleptic manifestations appearing in the middle of the monitoring period for larvae and adults of the Leptinotarsa decemlineata species were identified. Mortality (%) was statistically analyzed using a one-way analysis of variance (ANOVA) and the resulting experimental results were compared with the LSD-Fisher’s test (p < 0.05). The highest mortality (%) was observed after 24 h of treatment with extracts of Origanum vulgare at 100% concentration, while the maximum effect was recorded after 48 h for Origanum vulgare at 60% and 100% concentrations.
Verilog Design, Synthesis, and Netlisting of IoT-Based Arithmetic Logic and Compression Unit for 32 nm HVT Cells
Authors: Jujjavarapu Raj Mouli , Poulose Alwin
Published: September 2022

Micro-processor designs have become a revolutionary technology almost in every industry. They brought the reality of automation and also electronic gadgets. While trying to improvise these hardware modules to handle heavy computational loads, they have substantially reached a limit in size, power efficiency, and similar avenues. Due to these constraints, many manufacturers and corporate entities are trying many ways to optimize these mini beasts. One such approach is to design microprocessors based on the specified operating system. This approach came to the limelight when many companies launched their microprocessors. In this paper, we will look into one method of using an arithmetic logic unit (ALU) module for internet of things (IoT)-enabled devices. A specific set of operations is added to the classical ALU to help fast computational processes in IoT-specific programs. We integrated a compression module and a fast multiplier based on the Vedic algorithm in the 16-bit ALU module. The designed ALU module is also synthesized under a 32-nm HVT cell library from the Synopsys database to generate an overview of the areal efficiency, logic levels, and layout of the designed module; it also gives us a netlist from this database. The synthesis provides a complete overview of how the module will be manufactured if sent to a foundry.
Digital Twins and Industry 4.0 Technologies for Agricultural Greenhouses
Authors: Slob Naftali , Hurst William
Published: September 2022

Digital twin (DT) is one of the key concepts of the fourth industrial revolution (Industry 4.0). A DT is a data-driven, digital replica of a real-world object or environment, including all the states and behaviour of the real-life counterpart. Based on research across multiple domains, DTs show great potential to improve both efficiency and sustainability. In addition, a DT is able to remove key constraints of human observations and interactions. Yet, the technology is still in its infancy. Thus, this article presents a literature search across five different databases focusing on suitable approaches for data coupling and the stages of DT implementation integration with Industry 4.0 technologies. The review process follows the systematic literature review (SLR) methodology. The selected articles cover a wide range of DT implementations across the agricultural industry, ranging from arable farming to aquaponics. Findings include identification of the stages needed to create the DTs, the data coupling processes, and how Industry 4.0 technologies (e.g., cloud-based technologies, IoT, and AI subfields) are integrated. Findings presented in this article will support others in the design of DTs and integration of Industry 4.0 technologies for agricultural greenhouses.
Deciphering the Global Proteomic Profile Involved in Methylmercury-Induced Cerebellar Neurodegeneration and Motor Dysfunction in Adult Rats
Authors: Bittencourt Leonardo Oliveira , Matta Pedro Philipe Moreira , Nascimento Priscila Cunha , Eiró-Quirino Luciana , Aragão Walessa Alana Bragança , Dionizio Aline , Fernandes Luanna Melo Pereira , Silva Márcia Cristina Freitas , Buzalaf Marília Afonso Rabelo , Aschner Michael , Crespo-Lopez Maria Elena , Maia Cristiane Socorro Ferraz , Lima Rafael Rodrigues
Published: September 2022

Mercury is a ubiquitous pollutant in the environment with potential neurotoxic effects. Several populations are susceptible to mercurial exposure, especially methylmercury (MeHg) at low doses for long periods through food consumption. Given this, the present work aimed to assess the effects of long-term MeHg exposure on the cerebellum of rats from a translational perspective using a representative dose, assessing molecular, biochemical, morphological, and behavioral parameters. The model was produced by administering 40 µg/kg of MeHg for 60 days to adult male Wistar rats by oral gavage. As a result of this exposure, the animals presented motor deficits in open field and rotarod tests which were associated with an increase in total mercury content in cerebellar parenchyma, a reduction in antioxidant competence against peroxyl radicals, and increased nitrite and lipid peroxidation levels. The proteomic approach showed 317 modulated proteins. Such findings were associated with reductions in mature neuron and Purkinje cell densities and glial fibrillary acidic protein immunostained areas and increased microglial density. In addition, decreases in myelin basic protein and synaptophysin immunostaining were also observed. The results thus provided new evidence of the mechanisms underlying complex MeHg-induced neurodegeneration, especially the proteins underlying the biochemical and morphological features associated with motor dysfunction.
HIV Prevalence among Injury Patients Compared to Other High-Risk Groups in Tanzania
Authors: Barcenas Loren K. , Tupetz Anna , Behrens Shay , Kozhumam Arthi S. , Strand Eleanor , von Isenburg Megan , Sakasaka Philoteus A. , Rubach Matthew P. , Vissoci Joao Ricardo Nickenig , Park Lawrence P. , Bettger Janet Prvu , Mmbaga Blandina T. , Staton Catherine A.
Published: September 2022

Sixty-eight percent of persons infected with HIV live in Africa, but as few as 67% of those know their infection status. The emergency department (ED) might be a critical access point to HIV testing. This study sought to measure and compare HIV prevalence in an ED injury population with other clinical and nonclinical populations across Tanzania. Adults (≥18 years) presenting to Kilimanjaro Christian Medical Center ED with acute injury of any severity were enrolled in a trauma registry. A systematic review and meta-analysis was conducted to compare HIV prevalence in the trauma registry with other population groups. Further, 759 injury patients were enrolled in the registry; 78.6% were men and 68.2% consented to HIV counseling and testing. The HIV prevalence was 5.02% (tested), 6.25% (self-report), and 5.31% (both). The systematic review identified 79 eligible studies reporting HIV prevalence (tested) in 33 clinical and 12 nonclinical population groups. Notable groups included ED injury patients (3.53%, 95% CI), multiple injury patients (10.67%, 95% CI), and people who inject drugs (17.43%, 95% CI). These findings suggest that ED injury patients might be at higher HIV risk compared to the general population, and the ED is a potential avenue to increasing HIV testing among young adults, particularly men.
The Prevalence of Malaria and Bacteremia Co-Infections among Febrile Patients: A Systematic Review and Meta-Analysis
Authors: Wilairatana Polrat , Mala Wanida , Masangkay Frederick Ramirez , Kotepui Kwuntida Uthaisar , Kotepui Manas
Published: September 2022

Comprehensive data on the relative contribution of bacteremia to malaria outcomes in a large number of participants are lacking. Therefore, we collated data on the co-existence of malaria and bacteremia in the literature to provide evidence-based information for future studies investigating the clinical significance of this co-infection. The study protocol was registered at PROSPERO (ID: CRD42021287971). Relevant studies were identified from PubMed, Web of Science, and Scopus. The pooled prevalence of (1) co-existent malaria and bacteremia among febrile patients, (2) the pooled prevalence of bacteremia among patients with malaria, (3) the probability of co-infection, and (4) the pooled prevalence of deaths were estimated by the random-effects model. Fifty-one studies involving 1583 cases of co-infection were included in the analyses. Typhoidal Salmonella spp. and Staphylococcus aureus were the most common Gram-negative and Gram-positive bacteria, respectively. The prevalence of co-existent malaria and bacteremia among febrile patients was 1.9% (95% confidence interval (CI) = 1.5–2.2%, I2 = 96.64%, 31 studies). The prevalence of bacteremia among patients with malaria was 7.6% (95% CI = 6.7–8.7%, and I2 = 96.68%, 43 studies). Co-infection by malaria and bacteremia did not occur by chance (p = 0.024, odds ratio = 0.64, 95% CI = 0.43–0.94, and I2 = 95.7%, 29 studies). The pooled prevalence of deaths among patients with co-infection was 15.0% (95% CI = 8.0–23.0%, I2 = 75.23%, 8 studies). On the basis of this study, we conclude that although the prevalence of co-infection was low, patients with malaria appear at greater risk of bacteremia and death.
Kinetics of Degenerate Electron–Positron Plasmas
Authors: Vereshchagin Gregory , Prakapenia Mikalai
Published: September 2022

Relativistic plasma can be formed in strong electromagnetic or gravitational fields. Such conditions exist in compact astrophysical objects, such as white dwarfs and neutron stars, as well as in accretion discs around neutron stars and black holes. Relativistic plasma may also be produced in the laboratory during interactions of ultra-intense lasers with solid targets or laser beams between themselves. The process of thermalization in relativistic plasma can be affected by quantum degeneracy, as reaction rates are either suppressed by Pauli blocking or intensified by Bose enhancement. In addition, specific quantum phenomena, such as Bose–Einstein condensation, may occur in such a plasma. In this review, the process of plasma thermalization is discussed and illustrated with several examples. The conditions for quantum condensation of photons are formulated. Similarly, the conditions for thermalization delay due to the quantum degeneracy of fermions are analyzed. Finally, the process of formation of such relativistic plasma originating from an overcritical electric field is discussed. All these results are relevant for relativistic astrophysics as well as for laboratory experiments with ultra-intense lasers.
Auxotrophic Lactobacillus Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice
Authors: Zhang Hailin , Zhao Haiyuan , Zhao Yuliang , Sui Ling , Li Fengsai , Zhang Huijun , Li Jiaxuan , Jiang Yanping , Cui Wen , Ding Guojie , Zhou Han , Wang Li , Qiao Xinyuan , Tang Lijie , Wang Xiaona , Li Yijing
Published: September 2022

Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal strategy for blocking PoRV infections. However, the difficulty in knocking out specific genes, inserting foreign genes, and the residues of antibiotic selection markers are major challenges for the oral vaccination of LAB. In this study, the target gene, alanine racemase (alr), in the genome of Lactobacillus casei strain W56 (L. casei W56) was knocked out to construct an auxotrophic L. casei strain (L. casei Δalr W56) using the CRISPR-Cas9D10A gene editing system. A recombinant strain (pPG-alr-VP4/Δalr W56) was constructed using an electrotransformed complementary plasmid. Expression of the alr-VP4 fusion protein from pPG-alr-VP4/Δalr W56 was detected using Western blotting. Mice orally immunized with pPG-alr-VP4/Δalr W56 exhibited high levels of serum IgG and mucosal secretory immunoglobulin A (SIgA), which exhibited neutralizing effects against PoRV. Cytokines levels in serum detected using ELISA, indicated that the recombinant strain induced an immune response dominated by Th2 cells. Our data suggest that pPG-alr-VP4/Δalr W56, an antibiotic-resistance-free LAB, provides a safer vaccine strategy against PoRV infection.
Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
Authors: Papagiannis Dimitrios , Thireos Eleftherios , Mariolis Anargiros , Katsioulis Antonios , Gartzonika Konstantina , Malliaraki Niki , Agnantis Christos , Tsaras Konstantinos , Malli Foteini , Rouka Erasmia C. , Tsiaousi Ioanna , Symvoulakis Emmanouil K. , Rachiotis Georgios , Gourgoulianis Konstantinos I.
Published: September 2022

The reported cases of pertussis vary considerably globally. In the present nationwide study, we aimed to record the Bordetella pertussis prevalence in Greece by measuring serum IgG specific antibody levels to pertussis toxin (anti-PT IgG). General practitioners and laboratories participated in this study from 12 regions of Greece. A geographically stratified sampling plan based on regional units (NUTS level 2) was applied in order to produce a representative sample, taking into consideration age group (30–39, 40–49, 50–59, 60–69, 70–79 and 80+) and sex. In total, 1169 subjects participated in the study. The percentage of participants with anti-PT IgG antibodies higher than 50 IU/mL was 3.7%. The levels of anti-PT IgG antibodies of total sample ranged between 1.46 IU/mL to 126.60 IU/mL, with mean 17.74 IU/mL and standard deviation 14.03 U/mL (p-value < 0.001). The total seroprevalence of Greek regions for pertussis disease varied significantly among prefectures. The region with the highest seroprevalence was Peloponnese 21.3%, followed by the region of Central Greece 15.3%. The proportion of adults who have pertussis specific antibodies <50 IU/mL has been >90%, suggesting that a large number of adults may be vulnerable to infection of pertussis despite well-established vaccination programs in Greece. Despite the fact that vaccination reduced the number of reported pertussis cases in the last decades in Greece, our seroprevalence study may indicate that the herd immunity level among Greek adults is suboptimal.
Individual- and Neighborhood-Level Factors of Measles Vaccination Coverage in Niamey, Niger: A Multilevel Analysis
Authors: Kunieda Mika Kondo , Manzo Mahamane Laouali , Subramanian S. V. , Jimba Masamine
Published: September 2022

Vaccination is a proven equitable intervention if people take advantage of the opportunity to get vaccinated. Niger is a low-income country in West Africa, with a 76% measles 1 vaccination coverage rate in 2016. This study was conducted to identify individual- and neighborhood-level factors that could improve measles 1 vaccination coverage in Niamey, the capital. In October 2016, 460 mothers with children aged 12–23 months were surveyed. The outcome was to determine whether the mother’s child had been vaccinated against measles 1 or not. For individual-level variables of measles 1 vaccination status, the following were included: mother’s age group, mother tongue, maternal education level, husband’s job, where the mother gave birth (at home or at a health center) and whether the mother discussed vaccination with friends. Neighborhood-level factors were access time to the health center, household access to electricity, and a grand-mean-centered wealth score. Multilevel logistic regression analysis was performed. At the individual-level, primary and secondary-educated mothers were more likely to vaccinate their children against measles 1 (aOR 1.97, 95% CI 1.11–3.51). At the neighborhood-level, no factors were identified. Therefore, a strengthened focus on equity-based, individual factors is recommended, including individual motivation, prompts and ability to access vaccination services.
Healthcare Provider Recommendations and Observed Changes in HPV Vaccination Acceptance during the COVID-19 Pandemic
Authors: Osaghae Ikponmwosa , Chido-Amajuoyi Onyema Greg , Shete Sanjay
Published: September 2022

Healthcare provider (HCP) recommendation of the human papillomavirus (HPV) vaccination is crucial for HPV vaccination acceptance and uptake. It is unclear to what extent the disruptive effect of the COVID-19 pandemic impacted the recommendation and acceptance of HPV vaccination. HCPs practicing in Texas were invited to complete an online survey between January and April 2021. This population-based survey examined the association between HPV vaccination recommendation by HCPs and their observed changes in HPV vaccination acceptance during the COVID-19 pandemic. Of the total 715 HCPs included in this study, 13.9% reported a decrease, 8.7% reported an increase, and 77.5% reported no change in HPV vaccination acceptance during the COVID-19 pandemic. Compared to the HCPs who never/sometimes recommend HPV vaccination, those who often/always recommend HPV vaccination were less likely to observe a decrease (12.3% vs. 22.1%) and more likely to observe an increase in HPV vaccination (9.1% vs. 6.2%), during the COVID-19 pandemic. Furthermore, those who provided recommendations often/always had 46% (odds ratio: 0.54; 95%CI: 0.30–0.96) lower odds of reporting a decrease in HPV vaccination acceptance during the COVID-19 pandemic. This study adds to prior evidence of the positive influence of provider recommendations on HPV vaccination acceptance despite the disruptive effect of the COVID-19 pandemic on cancer prevention services.
A Pilot Randomized Trial to Compare Polyuria and Polydipsia during a Short Course of Prednisolone or Methylprednisolone in Dogs with Atopic Dermatitis
Authors: Lokianskiene Viktorija , Bergvall Kerstin , Olivry Thierry
Published: September 2022

Glucocorticoids are widely used to treat canine allergic disorders, but they frequently cause polyuria and polydipsia (PUPD). At equipotent dosages, oral methylprednisolone is believed to cause less PUPD than prednisolone. We performed a pilot randomized, open, parallel trial with 22 dogs with nonseasonal AD receiving either prednisolone or methylprednisolone at equipotent dosages, once daily for 14 days during the first phase of a restriction–provocation dietary trial. Before and on days 3, 7, and 14 after starting the glucocorticoids, owners estimated water consumption for 24 h. On the same days and before the glucocorticoid was given, owners collected the first-morning urine to determine the urine specific gravity (USG). There were no significant differences between the prednisolone and methylprednisolone groups on days 3, 7, and 14 when comparing the changes in water intake from baseline. Most dogs from both groups exhibited a slight reduction in USG during the study. Still, there was no significant difference in USG changes between the groups on any of these three reevaluation days. In conclusion, the administration of two weeks of oral prednisolone and methylprednisolone at equipotent anti-inflammatory dosages at the beginning of an elimination diet did not lead to significant differences in water intake and USG.
Experience and evidence of clinical efficacy of local use of ozonated vegetable oil in the complex therapy of chronic adenoiditis
Authors:   Federal State Budgetary Educational Institution of Higher Education «South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia, Shchetinin C. A.
Published: September 2022

The article presents the results of a study of the effectiveness and safety of the topical use of ozonized vegetable oil. The use of local ozone therapy in the form of applying ozonated oil to the mucous membranes of the pharyngeal tonsil in the complex treatment of chronic adenoiditis contributes to the normalization of innate and adaptive immunity and the relief of the inflammatory process in the pharyngeal tonsil. Therapy with the use of modified forms of oxygen has proven to be highly effective in clinical, immunological and microbiological parameters.
Increasing the level of digital knowledge as the key to the country’s energy security
Authors:   Department of Civil and Business Law, Moscow University for the Humanities, Pronina Elena Vasilievna
Published: September 2022

The article is devoted to the development and application of digital technologies in the country. The author believes that the pace of national economic growth and energy security of the country directly depend on the formation of a digital ecosystem and modern legal regulation of relations arising in the digital economy. The presented materials can be useful in the framework of training in economic and legal areas.
Concept of civil law protection of non-residential premises owners’ rights
Authors:   of Civil and Business Law, Moscow University for the Humanities, Kurpyakova Svetlana Ivanovna , Kozhevnikova Natalya Sergeevna ,   of Civil and Business Law, Moscow University for the Humanities
Published: September 2022

The article provides a theoretical analysis of civil law protection of the rights of the nonresidential premises owner. The concept and the main ways of civil law protection are considered. The difference between civil law protection and protection of rights and legitimate interests in other branches of law is shown. The article contains the data that may be useful in the framework of training in legal areas
Primary care blood tests before cancer diagnosis: National Cancer Diagnosis Audit data
Authors: Cranfield Ben M , Koo Minjoung Monica , Abel Gary A , Swann Ruth , McPhail Sean , Rubin Greg P , Lyratzopoulos Georgios
Published: September 2022

Background

Blood tests can support the diagnostic process in patients with cancer but how often they are used is unclear.

Aim

To explore use of common blood tests before cancer diagnosis in primary care.

Design and setting

English National Cancer Diagnosis Audit data on 39 752 patients with cancer diagnosed in 2018.

Method

Common blood test use (full blood count [FBC], urea and electrolytes [U&E], and liver function tests [LFTs]), variation by patient and symptom group, and associations with the primary care interval and the diagnostic interval were assessed.

Results

At least one common blood test was used in 41% (n= 16 427/39 752) of patients subsequently diagnosed with cancer. Among tested patients, (n= 16 427), FBC was used in 95% (n= 15 540), U&E in 89% (n= 14 555), and LFTs in 76% (n= 12 414). Blood testing was less common in females (adjusted odds ratio versus males: 0.92, 95% confidence interval [CI] = 0.87 to 0.98) and Black and minority ethnic patients (0.89, 95% CI = 0.82 to 0.97 versus White), and more common in older patients (1.12, 95% CI = 1.06 to 1.18 for ≥70 years versus 50–69 years). Test use varied greatly by cancer site (melanoma 2% [n= 55/2297]; leukaemia 84% [n= 552/661]). Fewer patients presenting with alarm symptoms alone were tested (24% [n= 3341/13 778]) than those with non-alarm symptoms alone (50% [n= 8223/16 487]). Median primary care interval and diagnostic interval were longer in tested than non-tested patients (primary care interval: 10 versus 0 days; diagnostic interval: 49 versus 32 days, respectively,P<0.001 for both), including among tested patients with alarm symptoms (primary care interval: 4 versus 0 days; diagnostic interval: 41 versus 22 days).

Conclusion

Two-fifths of patients subsequently diagnosed with cancer have primary care blood tests as part of their diagnostic process. Given variable test use, research is needed on the clinical context in which blood tests are ordered.
Theopreneurship dalam Kemandirian Finansial Gereja Perintisan
Authors: Sihite Franseda , Mendrofa Henny P
Published: September 2022

Financial independence is very important to ensure the continuation of the ministry of a newly started church. The pastor's family's financial needs and church facilities can be supported by the way the servant of God is an entrepreneur. Theopreneurship contains a theological dimension, namely as a mandate given by God to pastors to manage the potential of themselves and their congregations, even though there are different views about whether a servant of God is an entrepreneur. This study uses the Literature Study method to explain the interests and efforts of a servant of God in entrepreneurship to support the financial independence of the pioneering church. The results of the study found that a servant of God who is starting a new church should be self-employed as a Theopreneur, who acts as a servant (doulus and huperetes) and steward (oikonomos) and also needs to teach, involve and mentor members of the congregation or community whom he serves for joint entrepreneurship so as to effectively achieve the financial independence of the pioneering church for the glory of the Kingdom of God.AbstrakKemandirian finansial sangat penting menjamin kelanjutan pelayanan sebuah gereja yang baru dirintis. Kebutuhan keuangan keluarga gembala dan fasilitas gereja dapat ditopang dengan cara hamba Tuhan itu berwirausaha. Theopreneurship mengandung dimensi teologis yaitu sebagai mandat yang diberikan Tuhan kepada para gembala untuk mengelola potensi diri dan jemaatnya, meski ada perbedaan pandangan soal baik buruknya seorang hamba Tuhan berwirausaha. Penelitian ini menggunakan metode Studi Literatur untuk menjelaskan kepentingan dan upaya seorang hamba Tuhan melakukan wirausaha guna mendukung kemandirian finansial gereja perintisan. Hasil penelitian mendapatkan bahwa seorang hamba Tuhan yang sedang merintis gereja baru patut berwirausaha secara mandiri sebagai seorang Theopreneur, yang berperan sebagai seorang pelayan (doulus dan huperetes)  dan penatalayan (oikonomos),  juga perlu mengajar, melibatkan dan melakukan mentoring terhadap anggota jemaat atau masyarakat yang dilayaninya untuk berwirauaha bersama sehingga efektif mencapai kemandirian finansial gereja perintisan bagi kejayaan Kerajaan Allah.
Estado de bem estar social enquanto desdobramento do estado nação
Authors: Duarte Ana Beatriz
Published: September 2022

O Estado Nação pode ser considerado um desdobramento do Estado moderno, teorizado pelos contratualistas em sua concepção clássica. Ao fim do século XVIII, o Estado Moderno assume a forma de Estado Nação, impulsionado por um processo de industrialização crescente, uma sociedade cada vez mais sedenta de igualdade, e pelas revoluções resultantes do novo cenário. O papel homogeneizador do Estado via nacionalismo foi fundamental para a manutenção da ordem política, que se viu ameaçada pelo multiculturalismo decorrente da nova configuração geopolítica da Europa no pós-guerra. O Estado do Bem Estar Social ou Estado Social surge nesse contexto como artifício para garantir o sucesso do projeto homogeneizador do Estado Nação, mesmo sob novos desafios.
Identidades e saberes em fronteira: questionando categorias universalizantes e binárias
Authors: Matheus Ribeiro Junior Alexandre
Published: September 2022

Resumo

Este artigo discute o fenômeno das identidades que são atravessadas por diferentes opressões na sociedade, tais como as identidades de bichas pretas. Essa questão é utilizada para pensar tanto as categorias universalistas como  as categorias essencialistas e unitárias produzidas por movimentos sociais que se prendem às oposições binárias para pautar suas identificações. Também são desenvolvidas reflexões sobre as identidades na contemporaneidade através das produções de Tadeu Silva, Stuart Hall e Avtar Brah. Essas reflexões são revestidas pelo complemento e por críticas que trazem tanto o conceito de interseccionalidade, construído por Kimbelé Cranshaw, e sua presença na obra de Patricia Hill Collins; quanto pelas elaborações teóricas de Donna Haraway do conceito de identidade em fronteira e saberes localizados.

Palavras-chave: Identidade em fronteira. Interseccionalidade. Saberes localizados.

Abstract

This article discusses the phenomenon of identities spanned by different oppressions in society, such as the black queer. This issue is employed to think the universalizing, as the essentialist and unitary categories produced by social movements attached to binary oppositions in order to guide their own identifications. Reflections on identities in contemporaneity are also developed through the productions of Tadeu Silva, Stuart Hall and Avtar Brah. These reflections are enlightened through the concept of intersectionality built by Kimbelé Cranshaw and whithin Patricia Hill Collins’ work and by Donna Haraway's theoretical elaborations regarding the concept of borderland identity and situated knowledge.

 

Keywords: Borderland Identity. Intersectionality. Situated Knowledge.
JOGO|DANÇA|LUTA VISUAL: aproximações entre capoeira e fotografia
Authors: Rego Vinci de Moraes Beatriz
Published: September 2022

Ao longo da minha vida, já havia participado de diversas rodas de capoeira. Minha participação começou ainda como criança capoeirista que, de dentro dela, praticava as aulas de regional da escola. Com o passar dos anos, a minha presença deixou de estar no jogo de dentro e passou a ser da pessoa que, de fora, assiste ao desenvolvimento desta luta dançada, e era a roda quem vinha ao meu encontro - como tropeços - em viagens pelo Brasil. Ultimamente, minha presença na capoeira foi diferente; eu quem fui ao seu encontro, com uma câmera na mão.
Judith Butler e Paul Beatriz Preciado:
Authors: De Almeida Trindade Braga Patrick , Gross Alexis Emanuel
Published: September 2022

O presente trabalho se propõe a contrastar dois modelos teóricos da construção da identidade de gênero dentro da teoria queer: o modelo performativo-teatral de Judith Butler e o biodrag de Paul Beatriz Preciado[1]. Para atingir esse objetivo, procede-se em dois passos. Primeiro, analisa-se a crítica de Butler à metafísica de gênero e se apresentam os contornos centrais de seu modelo performativo-teatral. Em seguida, estuda-se o papel que os conceitos do capitalismo farmacopornográfico e o pós-moneísmo desempenham na obra de Preciado, para, em seguida, passar a uma análise de seu modelo biodrag

 

[1] A versão original do texto traz o nome Beatriz Preciado. Considerando a recente transição de gênero do autor, mas sem desconsiderar a versão original, opto por apresentar o nome Paul Beatriz. (Nota do Tradutor)
Há vida nas linhas
Authors: Batista Lima Mayane'
Published: September 2022

“Esta São Paulo;

São tantas cidades;

Nunca tantas quantas gostaria de ser;

 Ouvindo sampa no walkman;

 (vidro, concreto & metal)”

(Engenheiros do Hawaii - Sampa no walkman
retomada decolonial do conceito de Interseccionalidade
Authors: Povala Li Leticia
Published: September 2022

A presente resenha crítica tem o objetivo de apresentar a obra intitulada Interseccionalidade, de Carla Akotirene, a todas as pessoas que tenham interesse no conceito forjado a partir dos feminismos negros e de questões que perpassam, sobretudo, as vidas das mulheres negras. Nesse sentido, apresentam-se os pontos de destaque do texto, a forma como está estruturado, as principais disputas em torno do conceito, bem como as críticas e as contribuições para pensar a realidade e o feminismo brasileiros. Assim, articulam-se diálogos estruturados com base em múltiplas vozes de teóricas feministas em trânsito no Atlântico, tendo como alicerce as epistemologias dos feminismos negros e decoloniais.
Fragmentos de Escrevivência nas Poesias de Jovens Secundaristas.
Authors: Gomes Fernanda Cristina , De Carvalho Lisboa Maria Thereza , Imbrizi Jaquelina Maria
Published: September 2022

As experiências das juventudes de territórios atravessados pela desigualdade social convocam a poesia como artefato para imaginar outros modos possíveis de existência no mundo. O objetivo do artigo é investigar a manifestação cultural das juventudes a partir de articulações entre a noção de Escrevivência, de Conceição Evaristo, e trechos das poesias produzidas por secundaristas de uma escola pública em São Vicente/SP, publicadas no livro “Poesias Diversas - 2019”. Trata-se de contemplar a ideia de arte ampliada como ponto de ancoragem e a possibilidade de ficcionalizar de modo crítico lugares reservados às mulheres e aos jovens na estrutura social.
Биофаунистические заметки по млекопитающим южных отрогов хребта Черского (Магаданская область)
Authors:   Institute of Biological Problems of the North, FEB RAS, Magadan, Dubinin E. A.
Published: September 2022

Data on the species composition of theriofauna in the mountain-lake district of the Cherskiу Range southern spurs are given. New data on habitats, relative abundance, and some population characteristics of mass species of small mammals are also reported. The basins of Lake Momontay and Lake Urultun, located at 1048 and 944 m above the sea level and belonging to the basin of the Omulyovka River upper reaches, were inspected in August 2021. Small mammals were caught using the standard trap-line and cone methods. A total of 650 trap-days and 80 cone-days were worked out; 260 animals were caught. The species composition of large and medium-size mammals was identified by traces of their life activity and by visual contacts during route surveys of the total area about 350 km2. The routes made 50 km of length. 18 species of mammals referring to 16 genera, 9 families, and 5 orders were found to inhabit the area; they prevalently belong to the most numerous and elements of the theriofauna, widespread in the North-East of Siberia boreal Holarctic (Clethrionomys rutilus, Alexandromys oeconomus, Ursus arctos, Rangifer tarandus, Alces alces) and ancient taiga Palearctic (Sorex caecutiens, S. isodon, Myopus schisticolor, Craseomys rufocanus, Martes zibellina). A new habitat (the northwestern coast of Lake Momontai) was identified for the North Siberian vole (Alexandromys hyperboreus). Besides, the findings of the equal-toothed shrew (Sorex isodon) in the study area expand its distribution borders 160-180 km to the north of the Upper Kolyma basin.
Penguatan Pendidikan Karakter Siswa Sd Melalui Kearifan Lokal
Authors: Masruroh Masruroh , Pambudi Moch Rio , Aris Ayub Pratama , Ninasafitri Ninasafitri , Permana Aang Panji
Published: September 2022

Character education is an effort to prevent the growth of bad characters for the younger generation, especially through the introduction of local wisdom cultural values. Character values that must be instilled in students in the current era of very rapid technological development is by providing character education which includes knowledge, awareness and action to be implemented in everyday life. The purpose of this community service is to provide strengthening character education through local wisdom of SDN 03 Kabila Bone students in Molotabu Village, Gorontalo. The target of this activity is elementary school students. The method used in this community service activity is student participation. Involve students directly with assistance during activities. The results of the evaluation showed that all educators followed the character education strengthening material with the results that 89% of participants were in the good category and 11% in the sufficient category. Thus strengthening character education through local wisdom can be said to be good by providing socialization and concrete actions that will be remembered by students in preserving and caring for the environment. This activity is expected to have a positive impact as an educational effort for students at SDN 03 Kabila Bone, Molotabu village, Gorontalo.
The capture Ḥaṭrā in light of military and political activities of Ardašīr I
Authors: MAKSYMIUK Katarzyna
Published: September 2022

Ḥaṭrā was a city in Upper Mesopotamia which gained strategic importance in Irano-Roman border zone in 2nd century AD and managed to successfully resist the attempts of capturing by the Roman army. Power shift in Iran which resulted in taking over of Iranian throne by Ardašīr I (224-242) changed the situation of Ḥaṭrā. Below considerations are an attempt to analyze economic, political and first of all military factors which allowed capturing the city in 240/241 by the Sasanian army.
O que fica nas entrelinhas da vida
Authors: Ximenes Erivalda
Published: September 2022

E olha eu aqui novamente, pela quarta vez, escrevendo uma apresentação. Este é um livro composto de textos e poemas que contêm a realidade do dia a dia, dos acontecimentos da vida e de tudo que nos cerca, tantos os momentos tristes como os alegres e tudo que faz parte da nossa vida. Nele eu escrevi coisas do viver exatamente como são e como vejo, sempre esperando um final feliz. Chama-se: “O que fica nas entrelinhas da vida”, porque sempre fica algo do que falamos por vários motivos, ou porque precisamos omitir, por esquecimento, ou simplesmente porque não deu tempo de se dizer tudo. O certo é que sempre fica alguma coisa. E se fôssemos em busca do que ficou? Do que poderíamos falar, escrever, pensar e dizer? No livro “O que fica nas entrelinhas da vida” escrevi textos com relatos familiares importantes passados na vida, como também há as poesias daquilo que o coração sente e que se transformam em belos poemas.
Factors Related Of Anemia In Adolescence Girl
Authors: Vaira Rizky , Merlin Karinda  , Muflihah
Published: September 2022

Anemia during adolescence has a negative effect on growth, cognitive abilities, performance abilities and has a serious impact throughout the reproductive years. The study aims to determine the factors associated with the incidence of anemia in adolescent girls. This type of research method is a cross-sectional study. The sample in this study were female students of class XI and XII at SMAS PGRI 2 Banjarmasin who met the inclusion criteria totaling 75 people. Sampling technique with Total Sampling. The research instrument used measurements and questionnaires consisting of Body Mass Index (BMI), Middle-Upper Arm Circumference (MUAC), menstrual patterns and eating patterns. Data analysis using a computer program. The results showed that the female adolescents in SMAS PGRI 2 Banjarmasin who did not experience anemia were (70.7%) while the female adolescents who had anemia were (29.3%). There is a relationship between BMI and the incidence of anemia in adolescent girls p-value 0.023 (<0.05), there is a relationship between MUAC and the incidence of anemia in adolescent girls p-value 0.012 (<0.05), there is a relationship between diet and the incidence of anemia in adolescent girls p-value 0.021 (<0.05), there is a relationship between menstrual patterns with the incidence of anemia in adolescent girls p-value 0.026 (<0.05). Preventive and promotive efforts need to be done by increasing the consumption of nutritious food and giving blood-supplementing tablets especially for female students.
The Analysis of Brand Extension Reputation on the Intention in Choosing Private University in Indonesia
Authors: Sofia Evi , Yuliati Lilik Noor , Hartoyo Hartoyo , Soehadi Agus W.
Published: September 2022

Brand reputation is important when choosing an education. Universities that already have a brand reputation can more easily attract prospective new students. There is a phenomenon where Private Universities are using extended brand reputation to compete. The purpose of this research is to analyze the impact of brand extension reputation on the intention in choosing private universities. The quantitative research method of Structural Equation Modeling uses a structured questionnaire. The questionnaires have been distributed to the students, and have been completed by email. It is a self-administrated method. The survey was conducted on students at  one of Aperti (Aliansi Perguruan Tinggi) BUMN (Badan Usaha Milik Negara) with a total sample of 400 respondents using quota sampling. The results showed that the parent brand of BUMN had a significant influence on the extended brand of  Aperti BUMN, which impacted student intention  when choosing the university. Brand extension reputation has an indirect effect on intention  through output expectation
The Effect of Social Support and Interest in Online Learning on Student Achievement Motivation
Authors: Ahmad Masduki , Rochimah Heni , Fajaria Nurul Hasanah
Published: September 2022

Changes in the order of learning, which are all face-to-face to online, certainly have many consequences, one of which is the aspect of achievement motivation. This study determines how social support and interest in online learning influence student achievement motivation. This study uses a quantitative approach by distributing online questionnaires. The population of this study is 2200 students using the slovin formula (5%), so the sample in this study is 338 students. Data analysis techniques include multiple linear regression with t-test and F-test as hypothesis testing. The calculation results of the data obtained by the multiple linear regression equation are Y = 41.561 + 0.471 - 0.189, with a large influence on social support and online learning interest with the student achievement motivation variable, namely 53.6%. The results of the hypothesis test obtained are tcount for social support variable 10,600 ttable (1,967), count for online learning interest variable 5,161 ttable (1,967. Simultaneously, Fount 194,868 Ftable 3.02. Based on these results, it is stated that the variables of social support and interest are online learning has a positive and significant effect on students' achievement motivation variables.
Development Of Android-Based Edutainment Game Learning Media On Phytagoras Theorem For Junior High School Students
Authors: Susanti Vera Dewi , Suprapto Edy , Wardani Yuli Anis
Published: September 2022

Distance learning during the COVID-19 pandemic caused students' learning motivation to decrease. For this reason, an interesting learning process is needed, one of which is by applying game-based learning.This study aims to develop and determine the feasibility of an Android-based edutainment game learning media on the Pythagorean theorem material for junior high school students. This type of research is Research and Development (RD) using the ADDIE development model, namely Analyze, Design, Development, Implementation, and Evaluation. This research was conducted at MTs Muttaqien PSM Takeran in June 2021. The results of the research on the development of android-based edutainment game learning media include 1) Android-based edutainment game learning media meets the validity criteria with the combined validation average score by the media validator of 84.10% and is included in the fairly valid category, 2) Edutainment game learning media android-based meet the practicality criteria obtained from the average results of filling out student response questionnaires of 87.50% and is included in the very practical category, 3) Android-based edutainment game learning media meets the effectiveness criteria obtained from student learning outcomes tests with a score of N- The gain is 62.32% and is included in the medium category. Thus, it can be concluded that the Android-based edutainment game learning media is feasible to use in learning mathematics on the Pythagorean theorem material. The results of this study provide a contribution in the form of an Android-based edutainment game learning media that is used as an alternative in the learning process.