bluuebunny/crossref_metadata_2025 huggingface dataset:
The Competitiveness and Export Performance of Indonesian Coffee in The Organization of Islamic Cooperation (OIC)
Authors: Zuhdi Fadhlan , Asshagab Sri Milawati , Rambe Khoiru Rizqy , Destiarni Resti Prastika
Published: October 2024

Since its establishment in 1969, the Organization of Islamic Cooperation (OIC) has served as a platform for Islamic countries worldwide to cooperate in various sectors, including economic, social, and cultural. One longstanding form of economic cooperation among OIC countries is in the field of trade. Indonesia, as one of the major producers and exporters of coffee, has engaged in coffee trade with OIC countries, and this cooperation has continued to the present day. This research aims to assess the competitiveness and export performance of Indonesian coffee to OIC using the Revealed Comparative Advantage (RCA) and Constant Market Share (CMS) methods. The results show that Indonesian coffee exports to OIC are competitive but have a declining growth rate. Meanwhile, the export performance of Indonesian coffee to OIC demonstrates good performance in following market distribution trends but shows shortcomings in meeting market preferences. Therefore, enhancing internal trade cooperation within OIC, partnering strategies with competing countries, and measures such as improving technology accessibility and evaluating responsive export policies are necessary.
True and apparent satellite‑framed Romance. Romansh and northern Italian varieties
Authors: Acedo‑Matellán Víctor
Published: October 2024

Les varietats romàniques del nord d’Itàlia i certes varietats del romanx presenten construccions de verb amb partícula, la qual cosa ha fet pensar que es tracta de llengües d’emmarcament en el satèl·lit (Talmy 2000). Tanmateix, només en romanx la partícula és realment obligatòria perquè es preservi el sentit de direccionalitat, com en germànic. Altres fets suggereixen la naturalesa d’emmarcament en el satèl·lit de les varietats romanxes. A la resta de varietats romàniques, el verb pot codificar la direccionalitat per si mateix. El contacte amb el germànic podria haver induït una reanàlisi de la partícula en romanx perquè esdevingués el codificador de la direccionalitat.
Pronominal innovation and agreement patterns in European Portuguese dialects
Authors: Martins Ana Maria
Published: October 2024

The Portuguese pronominal system includes the pronouns "a gente" (‘we’) and "vocês" (‘you[plural]’), which resulted from the grammaticalization of (full) nominal phrases. In this paper, it is proposed that these pronouns are (generally, the former; dialectally, the later) morphologically underspecified (i.e. their person or person and number features have no specified values) and this lies behind the variation in verbal/predicate agreement patterns they exhibit. It is shown that an underspecification approach accounts better for the set of data (and their geolinguistic distribution) offered by the "Syntax‑oriented corpus of Portuguese dialects" (CORDIAL‑SIN) than the analyses that assume feature‑mismatch between semantic and morphological features for the pronouns "a gente" and "vocês".
Derivación y diacronía. Variación morfohistórica en situaciones de competencia afijal
Authors: Buenafuentes De La Mata Anna
Published: October 2024

This paper shows a methodological guideline to approach the investigation of affix competition situations from a historical point of view. Specifically, we propose three ways for analyse the diachronic affixal rivalry: firstly, we establish a typology of diachronic competition according to whether the rivalry can be traced back to Latin and whether a chronological sequence can be established between the rival derivatives. Secondly, we propose two patterns of rivalry evolution: one with loss and the other with maintenance of the rivalry. Finally, both internal and external factors that may condition the creation, resolution or preservation of competition are discussed. To show the viability of the proposal, examples of derivatives with competing suffixes are used.
Contraste morfosintáctico y léxico‑semántico a partir de un corpus bilingüe español‑catalán de fraseologismos
Authors: Prat Sabater Marta , García Rodríguez Joseph
Published: October 2024

Contrastive phraseology remains a pending task for researchers, despite the fact that in recent decades there has been a considerable increase in publications concerning evidence of similarities and differences between different languages. This lack is observed, above all, in languages such as Spanish and Catalan, so the objective of this study is to analyse, from the contrastive perspective, some phraseological units that contain the word "cielo/cel" in these languages to find out the points of union and dissimilarities, above all, but not exclusively, in the morphosyntactic and lexical‑semantic aspects. The data have been extracted from various lexicographic sources and language portals. It is concluded that partial equivalents are the most significant, although it should be noted that under this type of equivalence a gradation can be drawn based on the differences found.
Metáforas y creencias populares en los atlas lingüísticos. Los nombres del "padrastro del dedo"
Authors: Julià Luna Carolina
Published: October 2024

This article investigates the denominative variation of the ‘hangnail’ in three Iberian Romance varieties (Spanish, Catalan and Galician). The study examines linguistic atlases data from the perspective of cognitive semantics. The analysis demonstrates, on the one hand, that it is a concept with a high degree of lexical semantic variation and, on the other hand, the importance of popular beliefs in the motivation that originates a great part of the names of this reality. The results obtained allow us to complement the data from Colon’s research (1968, 1989a and 1989b) on this concept and expand the information on the origin of its variation from a historical and diatopic perspective in Romance varieties.
The role of the innovation ecosystem as a tool for innovation development
Authors: Fomenko D.V. , Nizhnikov О.M. , Pimenov V.S.
Published: October 2024

The development of various industrial sectors is one ofthe priority tasks of the state, the solution of which is toimprove the quality and life expectancy of the population.According to the authors of the article, an innovationecosystem should be understood as an open dynamicsystem that provides collaborative forms of interaction between actors, taking into account the non-hierarchical relationships that have developed within the institutional ecosystem of enterprises, regions, and countries acting inthe direction of sustainable advanced innovativedevelopment based on modern technological concepts.Modern innovation ecosystems are created and functionto overcome individual limitations, maximise resourceuse, and distribute risks and costs to better achievecommon goals. This approach differs from the traditionalones in that it takes into account the current level ofeconomic development, taking into account the processesof digital transformation of all spheres of activity andprovides an integrated approach to the formation of aninnovation ecosystem.
The article concludes that industry is currentlydeveloping as a traditional innovation system. The analysis of different views and main approaches tounderstanding innovation ecosystems allowed to identifythe advantages of ecosystems in comparison withtraditional innovation systems and to justify the need todevelop industry as an innovation ecosystem. A moredetailed study was carried out on the basis of market datafor various types of equipment. These conclusions wereconfirmed when analysing the prerequisites for theformation of an innovation ecosystem based on theresults of the analysis of the current state of theequipment market. A number of systemic problems canbe identified that are common to all stages of productionand circulation of various products: limited financialresources of manufacturers for development (researchand development, sales and promotion of products);scientific and technological lagging behind the level ofworld leaders; difficulty in commercialisingdevelopments.
These problems have a complex impact on thedevelopment of the industry as a whole and its individual product segments. Eliminating these constraints will helpcreate favourable conditions for the machinery marketand unlock its potential.
DOS PROCESSOS HISTÓRICOS DE POVOAMENTO ÀS TRANSFORMAÇÕES RECENTES NA CIDADE DE ARARI - MARANHÃO
Authors: Viana Willian Carboni
Published: October 2024

O presente trabalho tem objetivo de compreender o espaço urbano do município de Arari, situado na porção Norte do estado do Maranhão, verificando-se cronologicamente desde os processos históricos de povoamento às situações mais recentes de ocupação e expansão da malha urbana. O artigo parte da perspectiva da pequena cidade, cuja redistribuição da população pelo êxodo rural ocasionou um desnecessário inchaço urbano. Metodologicamente, buscou-se aproximação com a abordagem qualitativa, usando de procedimentos inerentes ao estudo de caso. Os resultados contemplaram o instalação do núcleo urbano arariense em decorrência do modo de colonização, intensificando o crescimento citadino na medida em que os processos de industrialização e modernização promoviam as mudanças nas dinâmicas espaciais. A saída do campo, mais acentuadamente a partir dos anos 1980, impulsionou a ampliação desordenada da cidade, que nos últimos 20 anos esteve relacionada ao encarecimento dos lotes nas partes centrais, especulação imobiliária e dificuldade no acesso à terra por parte da população de baixa renda. O que, acrescido da falta de atuação do Estado, tem potencializado o estabelecimento de habitações em áreas de risco, em condições de vulnerabilidade ambiental, econômica e social.
Modification of Risers in Buried Pipe Irrigation System to Improve their Performance
Authors: Islam Mohammad Raihanul , Barman Zikesh , Johora Rukia Tuz , Rahman Md Zillur , Sajib Md
Published: October 2024

This study identified the problems associated with the design, construction, operation, and maintenance of risers in buried pipe irrigation systems and proposed a modified design. The problems of buried pipe irrigation systems were assessed by inspecting three deep tube wells (DTWs) supplying water through buried pipes with twenty-five outlets. One DTW of the Bangladesh Agricultural Development Corporation (BADC) with five outlets in Netrokona, and one with fifteen outlets in Bara Kailati village and one with five outlets in Bali Bazar, both in Netrokona Sadar, were selected. Data were collected from farmers, field staff, and management authorities by employing pretested questionnaires and field investigations. Site visits revealed that the primary problems were the water leakage through outlets and cracks in the riser structure around the outlet. These problems were due to unsuitable outlet design of the buried pipe system. To overcome these problems, the riser design has been modified structurally, that may lead the buried pipe to suitable and durable performance of buried pipe irrigation system and reduce water losses.
J Bangladesh Agril Univ 22(2):225-230, 2024
Taxonomic Study on the Six Species of Genus Magnolia
Authors: Jesia Nawrin Satter , Alam Mahbubul , Karmokar Arup , Ashrafuzzaman M
Published: October 2024

Magnolia, a genus comprising approximately 225 species of trees and shrubs in the family Magnoliaceae. Magnolia plants can be evergreen or deciduous and bear alternate smooth-margined leaves. In this paper six species of magnolia were studied based on morphological observations of taxonomically relevant traits. Among these, four species—Magnolia alba, Magnolia champaca, Magnolia grandiflora, and Magnolia liliifera—are previously documented, while two species, Magnolia figo, a 3–4 m tall shrub with a sweet banana scent, and Magnolia coco, are newly recorded additions to the flora of Bangladesh. This study focused on the leaf descriptions viz. average breadth and length, average size, fresh weight, and dry weight of leaves of the six species with their brief taxonomic description, morphology features, and identifiable pictures. In terms of relative average leaf size (RALS), Magnolia alba has the largest, while Magnolia figo has the smallest. M. champaca exhibits the highest water content, and M. coco has the highest dry matter percentage at approximately 47.03%. The conservation status of these species was evaluated, with four classified as Least Concern (LC) and two as Data Deficient (DD). The addition of Magnolia coco and Magnolia figo brings the total number of Magnolia species in Bangladesh to fourteen. Overall, this study on Magnolia will help future research projects, conservation efforts, and management activities by enhancing the understanding of the various uses of these species.
J Bangladesh Agril Univ 22(2): 158-165, 2024
Characterization and Conservation of Native Banana Germplasms Available in Salt Ecosystem
Authors: Musa Md Abu , Robbani Mahbub , Howlader Jewel , Labib Litun Ahmed
Published: October 2024

This study aimed to assess, conserve, and characterize banana germplasms in Bangladesh's coastal salt ecosystem, with the goal of improving cultivation resilience and sustainability under challenging environmental conditions. Thirty-five banana germplasms were subjected to in situ investigation, with 11 germplasms undergoing morphological characterization, revealing significant variations in key parameters. Additionally, 11 germplasms representing Musa species were collected for ex situ conservation at the Germplasm Center, Department of Horticulture, PSTU, with three, four, and four germplasms falling under Musa paradisiaca, Musa acuminata, and Musa sapientum, respectively. Notably, M. paradisiaca (kacha kola), M. acuminata (atia kola), and M. sapientum (table banana) exhibited promising traits in terms of morphological characteristics, total yield, and shelf-life. Among these, germplasm MP01 (M. paradisiaca), MA17 (M. acuminata), and MS09 (M. sapientum) demonstrated superior potential for maximizing production and profitability within the coastal salt ecosystem region. These findings offer valuable insights for banana cultivation in similar challenging environments, contributing to enhanced agricultural sustainability and livelihoods.
J Bangladesh Agril Univ 22(2):193-201,2024
Road Accidents: Contemporary Scenario and Policy Issues in Bangladesh
Authors: Naila Sharmeen  , Islam Md Rabiul
Published: October 2024

ln consideration of the size of the country, road network and vehicle population, the number of road accidents and deaths and injuries caused by such accidents in Bangladesh are one of the highest in the world. In the recent days, one of the most-talked topics is what can be done to make the road a safe place where death will not be an everyday occurrence. The alarming rate of dreadful road traffic accidents may have increased due to certain reasons: lack of political concern, lack of accountability of the relevant ministers and governmental bodies, incompetent drivers, inadequate punishment etc. In this paper, the road safety situation and some contemporary issues and priorities are briefly discussed in addressing the road safety problem. Fatality in road accidents is a critical phenomenon in developing countries. About 86 percent accident occurs in developing countries, although these countries own only 30 percent of vehicle fleet (Jahan, 2006:120). Providing safer roads through reducing accidents is now a priority issue for policy makers at the national level in developing countries. Using the secondary literature, this paper is intended to focus on the involvement of heavy vehicles and their operators in road accidents as well as their behavioral habits and attitudes. This article also focuses on accident statistics, major causes and finally some recommendations have been provided.
Journal of Bangladesh Institute of Planners Vol. 4. Dec 2011, pp. 45 - 55
Intra- and inter-rater reliability of goniometric finger range of motion using a written protocol
Authors: Nakai Takuya , Amano Satoru , Murao Chikako , Taguchi Haruki , Takahashi Kayoko
Published: October 2024

Introduction: Goniometric finger range of motion (ROM) is the most common outcome measure used for functional evaluation of finger joints, but its reliability is not well-evaluated. This study aimed to investigate intra- and inter-rater reliability of goniometric finger ROM using a written protocol for active, passive, and composite movements in healthy adults.
Methods: The design was a single-center, cross-sectional, reliability study. Participants were 20 healthy adults (mean ± standard deviation, 36.4 ± 10.9 years). ROM for active, passive, and composite movements of the fingers was assessed by three occupational therapists with at least 5 years clinical experience in the field of physical disabilities. To standardize the measurement method used, we developed a written protocol, stabilized the wrist position, and trained the evaluators. Intraclass correlation coefficient (ICC) values were used for the reliability analysis. ICC (1,1) was used for intra-rater reliability. ICC (2,1) was used for inter-rater reliability. Hand-shaped heatmaps were used to summarize the reliability data.
Results: Most of the results (88.7%) showed moderate to good intra-rater reliability (ICC ≥ 0.50), while inter-rater reliability showed less (69.0%). Both intra- and inter-rater reliability showed no trends between dominant and non-dominant hands, type of movement, finger, or joint.
Conclusions: Intra-rater reliability was relatively high and using a written protocol was beneficial. Inter-rater reliability tended to be lower, and differences in the physical structure of both raters and participants may have affected inter-rater reliability values.
Cytotoxic activity, selectivity, and clonogenicity of fruits and resins of Saudi medicinal plants against human liver adenocarcinoma
Authors: Alghamdi Ali Hendi , Ahmed Aimun A. E. , Bashir Mahadi , Abdalgadir Hiadar , Khalid Asaad , Abdallah Mohamed E. , Almaimani Riyad , Refaat Bassem , Abdalla Ashraf N.
Published: October 2024

Background: Edible fruits and resins provide various benefits to mankind including potential medicinal applications. This study aimed to determine the cytotoxicity, selectivity, and clonogenicity of fruits and exudates of certain Saudi medicinal plants (Anethum graveolens (BEP-09), Opuntia ficus-indica (L.) Miller (BEP-10), Boswellia serrata Roxb. ex Colebr. (BEP-11), and Commiphora myrrha (BEP-12)) against human liver adenocarcinoma (HepG2).
Methods: Initial cytotoxicity and cell line selectivity against different cell lines were screened using MTT assay. The most promising extract was subjected to gas chromatography-mass spectrometry (GC-MS) analysis to determine the main phytoconstituents. Clonogenicity was checked for the most active extract.
Results: The selected plants’ fruits and resins possess a significant cytotoxic activity estimated as IC50. The fruit of BEP-10 was found to be the most active extract against liver cancer cells (IC50 = 2.82) comparable to both doxorubicin (IC50 = 1.40) and camptothecin (IC50 = 1.11). It showed a selectivity index of 4.47 compared to the normal human foetal lung fibroblast (MRC5) cells. BEP-10 showed a dose-dependent clonogenic effect against HepG2 cells comparable to the effect of doxorubicin. The GC-MS chromatogram of BEP-10 extract revealed the presence of eight small polar molecules, representing 73% of the total identified compounds and the rest three molecules (27%) were non-polar constituents. The furan derivatives represent the chief components in BEP-10 (16.3%), while the aldehyde 5-(hydroxymethyl)-2-furancarboxaldehyde was found to be the main molecule (13.2%).
Conclusion: The fruits of BEP-10 have a potential cytotoxic effect particularly against HepG2. The identified phytoconstituents in the tested plant extract might contribute to the investigated cytotoxic activity.
PELATIHAN PEMIKIRAN BERBASIS RISIKO MENGGUNAKAN TEKNOLOGI KOMPUTER UNTUK MENINGKATKAN AKUNTABILITAS KANTOR DISTRIK NAVIGASI PALEMBANG
Authors: Sitepu Hans Victor
Published: October 2024

With its strategic role, the Palembang Navigation District Office has made substantial efforts to improve the quality of its services, particularly by conducting initiatives to develop Standard Operating Procedures for the many types of services it offers. One of the main activities in this series of activities is providing training entitled Risk-Based Thinking - Identifying Risk Aspects in Processes that can support Accounting and Management Information Systems. The author explains to the participants using three methods: the Lecture Method, the Question-and-Answer Method, and the Case Study Discussion Method, all of which are conducted face-to-face and divided into five sessions, beginning with the opening session, material presentation session, illustration session, question and answer session, and closing session. It is hoped that by participating in this training activity, participants will gain a better understanding of the concept and application of risk-based thinking, as well as skills in using various types of tools, techniques and computer technology commonly used in risk management, which will be integrated into the process of developing the new service procedures. According to the results of the post-activity interview, the Head of the Palembang Navigation Office was satisfied with the training results and his team's absorption of the content.
Movements and behaviour of southern right whales satellite-tracked in and beyond a subantarctic archipelago wintering ground
Authors: Weir CR , Fernandez S , Jackson JA , Miller A , Sucunza F , Slesser HW , Zerbini AN
Published: October 2024

The post-exploitation recovery of the south-west Atlantic southern right whale (SRW, Eubalaena australis) population has been affected by widespread calf mortalities, resulting in the development of an International Whaling Commission Conservation Management Plan (IWC-CMP). The coastal waters around the Falkland Islands (Malvinas) comprise a recently documented wintering ground for the population. In July 2022, we deployed satellite tags on 10 SRWs to better understand their occurrence around the islands and their connectivity with other geographic regions. The animals remained in the islands for 1 to 57 d following tagging. High-use habitats comprised waters <10 km off the north and north-east coasts of East Falkland, where they exhibited slow and varied movements consistent with breeding and social behaviours. Six whales, including all 3 confirmed females, subsequently continued to the major calving ground located at Peninsula Valdés (Argentina), where they remained for up to 84 d. During spring, almost all tagged whales utilised the Patagonian Shelf (70-140 m depth) as a foraging habitat. Three males travelled south-east after departing the islands and variously visited higher latitude foraging grounds including the South Orkney and South Shetland islands, Scotia Sea and Antarctic Peninsula. Telemetry provided valuable information on the spatial and temporal extent to which SRWs aggregate in Falkland Islands (Malvinas) waters during winter and supports growing evidence that the region is a high-use critical habitat supporting breeding behaviour. The region should be incorporated into future region-wide conservation efforts for the south-west Atlantic SRW population and merits recognition in the IWC-CMP.
Urban Areas outside the Centre and the Artistic Expression of the Spiš Region in the Eighteenth Century
Authors:   Comenius University Bratislava, Kolbiarz Chmelinová Katarína
Published: October 2024

Despite being centres of art, it is mainly outside large cities that the development of art takes place. This paper focuses on the Spiš region during the eighteenth century, the fi nal phase of a period during which various territories of the region were under the administration of the Hungarian or Polish crown. The fi rst part of the text explores the local sculpture and painting scene, with a particular focus on the two generations of artists of the Theresian era. Then the region serves as a model for non-central areas in terms of their typologies and place in art-historical and broader cultural-historical development. The paper analyses the current approaches to the issue of centre and periphery and discusses the impact of smaller towns and administrative settlements on the cultural and artistic profi le of the area.
A minőségi kolonoszkópia jellemzői gyulladásos bélbetegségekben
Authors: Molnár Tamás
Published: October 2024

A gyulladásos bélbetegségek esetén az ileokolonoszkópia az egyik legfontosabb diagnosztikus módszer, amelynek megfelelő minőségben történő elvégzése kulcsfontosságú az eredményes kezelés szempontjából. Míg a szűrő kolonoszkópiák esetén az adenomadetekciós ráta az egyik legfontosabb mérőszáma az endoszkópiának, a gyulladásos bélbetegség különböző szakaszaiban eltérő minőségi mutatók ismerete és betartása garantálja a megfelelő végeredményt. Az összefoglaló közlemény a speciális kritériumrendszer ismertetésén túl különös hangsúlyt helyez a bélelőkészítés, az aktivitási pontrendszerek és a leletírás sajátosságaira a gyulladásos bélbetegekben végzett vastagbéltükrözés kapcsán.
Extending Intensions: Exploring Deleuze and Guattari's Critique of Formal Logic in the Case of Intensional Logics
Authors: Ardoline Michael J.
Published: October 2024

In What is Philosophy?, Deleuze and Guattari critique the relationship between formal logic and philosophy. They argue that since philosophy is the creation of concepts that are intensional, and formal logic reduces concepts to their extension, formal logic then has no special providence to decide philosophical questions. This may strike the logic-inclined philosopher as outdated given that there are now formal intensional logics designed to model meaning rather than reference. However, it will be shown that these logics too fail to express the concept in a way that preserves its philosophical import. Doing so requires contrasting Deleuze and Guattari's account of the concept with Frege's to show how the latter persists even in intensional logics in the form of mathematical functions that are ultimately referential. This then results in support for Deleuze and Guattari's claim that formal logic is a useful tool, but that it is incapable of adjudicating philosophical disputes.
Penerapan Terapi Murottal Al-Qur’an dalam Asuhan Keperawatan pada Pasien Cedera Kepala dengan Penurunan Kesadaran di Ruang Rawat Inap HCU Bedah RSUP DR. M. Djamil Padang
Authors: Wahyuni Silvia , Netti Netti , Nidia Wira Heppy
Published: October 2024

Cedera kepala merupakan penyakit yang dapat menyebabkan terjadinya penurunan tingkat kesadaran pada seseorang. Berdasarkan hasil Riset Kesehatan Dasar tahun 2018, perbandingan angka kejadian cedera kepala di Indonesia pada tahun 2013 mencapai 8,2% dari populasi dan pada tahun 2018 meningkat menjadi 9,2%. Pemberian stimulasi sensorik berupa stimulasi auditori sedini mungkin sangat penting untuk kelangsungan hidup, kualitas hidup dan prognosis jangka panjang pada pasien cedera kepala karena pendengaran merupakan fungsi indera yang paling akhir berfungsi pada penurunan kesadaran. Tujuan karya tulis akhir ini menerapkan terapi Murottal Al-Qur’an dalam asuhan keperawatan pada pasien cedera kepala dengan penurunan kesadaran di ruang rawat inap HCU Bedah RSUP Dr. M. Djamil Padang. Metode Karya Tulis Akhir ini menggunakan pendekatan laporan kasus (case report). Praktek profesi magang dilakukan dari bulan Mei-Juni 2023. Populasi adalah seluruh pasien Cedera Kepala yang dirawat di ruang HCU Bedah RSUP. Dr. M. Djamil Padang pada bulan Mei-Juni 2023 sebanyak 4 orang. Sampel yang diambil dengan Teknik purposive sampling sebanyak 2 orang. Teknik pengumpulan data menggunakan metode wawancara, observasi, pemeriksaan fisik, pengukuran GCS dan studi dokumentasi. Hasil evaluasi dari intervensi yang diberikan pada pasien menunjukkan adanya pengaruh terapi Murottall Al-Qur’an Dalam Asuhan Keperawatan Pada Pasien Cedera Kepala Dengan Penurunan Kesadaran Di Ruang Rawat Inap HCU Bedah Rsup Dr. M. Djamil Padang.
A GALERIA COMERCIAL
Authors: Milward Júlia , Cabral Pinheiro Charlene
Published: October 2024

A Galeria Comercial nasce de um desejo colaborativo, a partir do qual uma curadora-artista (Charlene Cabral) convida uma artista-curadora (Júlia Milward) e juntas desenvolvem um projeto que conjuga ocupação, inserção e exposição de arte no ambiente comercial do centro de São Paulo. A proposta visa envolver de forma participativa outros artistas profissionais e tem como objetivo dialogar com públicos diversos, com ênfase especial naquelas pessoas que não têm o hábito de frequentar os usuais espaços expositivos de arte. Trata-se de um projeto artístico experimental, que busca tensionar os lugares designados para cada coisa e colocar em diálogo distintos modos de percepção, pautando também o papel do mercado na arte contemporânea e as barreiras de diversos tipos que excluem determinadas pessoas de serem públicos e/ou agentes desse sistema.
VIVO CONFORTAVELMENTE NO MUSEU, LONGE DAS MARÉS”, NOS ESCREVE O FUGITIVO POLÍTICO
Authors: Quinderé Natália
Published: October 2024

O ensaio discute os deslocamentos da palavra museu na novela A invenção de Morel (1940), de Adolfo Bioy Casares. Mediante esse exame, procura cavar uma relação entre os mitos miméticos e a máquina de Morel, na ilha museu. Um dos objetivos de pensar a produção de imagens e sua circulação ininterrupta é discutir os sentidos que podem conter o museu, enquanto edifício material e simbólico. No ensaio, esse regime imagético se aproxima dos deslocamentos da palavra museu, via a clássica interdição: proibido tocar! Por último, discutir (à deriva) os usos do museu, na novela de Bioy Casares, é uma tentativa de propor outros métodos para a escrita da história da arte que exponham, ainda que implicitamente, o colapso da representação.
BLANCO CENTRAL
Authors: Villena Fiengo Sergio
Published: October 2024

¿Cómo lidiar con el espectro de Sandino, exigente objeto de amor ante el cual, pese a todos los fracasos y desilusiones que la revolución sandinista experimentó, pareciera que siempre se está en falta? ¿Es aún posible reconocer en los pliegues de la memoria de “el espectro más famoso de Nicaragua” una fuente de energía moral  y espiritual capaz de atizar la potencia intempestiva de un  nuevo “salto de tigre” revolucionario? Mi interés se focaliza en las tentativas de respuesta surgidas desde el arte contemporáneo centroamericano en el periodo “posrevolucionario”, es decir, desde el Termidor electoral que puso fin al gobierno del FSLN (1979-1990) hasta el retorno de ese partido al gobierno en enero del año 2007.  De las múltiples propuestas artísticas que tratan ese tema, en este artículo me ocuparé de las que aporta el influyente artista y activista cultural Raúl Quintanilla, las cuales estudiaré con el trasfondo histórico de las distintas “vidas” por las que ha atravesado la imagen sobreviviente del espectro de Sandino hasta el fin del periodo revolucionario.
OS PRIMEIROS PASSOS NA XILOGRAVURA: FRANCISCO STOCKINGER
Authors: Zulietti Luis Fernando , Nogueira Silvia Helena
Published: October 2024

Este artigo pretende enfatizar o artista e sua representação da zona da prostituição no Rio de Janeiro, o Mangue, e seu no início na produção de xilogravuras em tacos de madeiras.  Stockinger buscou refletir uma cidade dentro da cidade, com muita luz, muito movimento e a dura profissão das mulheres do Mangue, gerando uma série de xilogravuras do Mangue, que mostram claramente a importância que dava ao trabalho das prostitutas. Suas xilogravuras são espelhos da realidade social de uma época.
Novel antimicrobial coating for hernia meshes
Authors: Kühn Klaus Dieter , Coraça-Huber Débora C. , Erdtmann Michael , Bernhardt Gerwin A. , Fölsch Christian
Published: October 2024

Purpose

Antibiotic coating for several medical devices has been carried out; however, there are only few studies about coating hernia meshes with antimicrobial substances. In this study we checked the capacity of different commercially available hernia meshes to act as drug carrier.

Methods

The meshes were coated with gentamicin palmitate, chlorhexidine palmitic acid and chlorhexidine palmitate. The coating mass and subsequent in vitro delivery rate were evaluated for gentamicin palmitate by fluorescence polarization. For Chlorhexidine coated devices the coating mass was determined by weighing. The in vitro delivery rate was determined by UV absorption (255 nm). The interaction of each mesh to the different coating substances was observed by scanning electron microscopy.

Results

1. Certain uniformity was observed on the quantity of chlorhexidine coating the surface of each mesh used when compared with gentamicin palmitate coating. 2.We did not detect significant difference between the amounts of gentamicin palmitate released from each mesh. 3. The release of chlorhexidine palmitate and chlorhexidine palmitic acid from UltraPro™ and Mersilene™ were significantly higher (p<0.05) in comparison with the other two meshes. 4. The coating substances covered the surface of the fibers without damaging its structure. 5. The coating substances were distributed all along the fibers in all samples.

Conclusions

We suggest the use of chlorhexidine palmitate and chlorhexidine palmitic acid, as well as gentamicin palmitate, for coating of hernia meshes aiming prevention of infections. Further investigation of the bactericidal effect of coated hernia meshes against biofilm form of S. aureus and other device-related infections is suggested.
Acetylsalicylic acid dosed at bedtime vs. dosed in the morning for circadian rhythm of blood pressure- a systematic review and meta-analysis
Authors: Nadeem Abdullah , Rais Taruba , Aamir Minahil , Habte Alexander , Siddiqui Tasmiyah , Karamat Riyan Imtiaz , Munsab Rabbia , Habib Ashna
Published: October 2024

Introduction

Cardiovascular disease (CVD) is a leading global cause of morbidity and mortality, with high systolic blood pressure (SBP) identified as a major risk factor. Aspirin (Acetylsalicylic acid—ASA) has been considered for CVD prevention, prompting questions about its optimal use in primary and secondary prevention and the ideal dosing time to maximize its impact on circadian blood pressure rhythms. Previous research suggests a potential benefit of bedtime aspirin dosing in reducing blood pressure, attributed to its effects on the renin-angiotensin-aldosterone system and nitric oxide production. This systematic review and meta-analysis aim to further explore the circadian effects of aspirin on blood pressure, focusing on the timing of administration.

Methods

Adhering to PRISMA guidelines, a comprehensive search of PubMed, Cochrane Library, and clinicaltrials.gov was conducted. Randomized controlled trials (RCTs) involving patients aged >18 with cardiovascular history and hypertension were included. The primary objective was to assess the impact of bedtime-dosed and morning-dosed aspirin on systolic and diastolic blood pressure. Low-dose aspirin was administered for primary or secondary prevention. The Cochrane Risk of Bias tool evaluated study quality. Meta-analyses were conducted using RevMan 5.3, with mean deviations and 95% confidence intervals employed for outcomes.

Results

Initial searches yielded 1,181 articles, with six studies meeting the inclusion criteria. These RCTs involved 1,470 patients, with 1,086 completing follow-up. Bedtime aspirin dosing demonstrated a significant reduction in both systolic and diastolic blood pressure compared to morning dosing (p < 0.05). Meta-analysis results for systolic blood pressure revealed a weighted mean difference of approximately 3.65 mmHg in favour of bedtime dosing, with low heterogeneity (I2 = 0%). For diastolic blood pressure, the weighted mean difference was 1.92, again favouring bedtime dosing, with 3% heterogeneity.

Conclusion

This meta-analysis, involving over 1,300 cardiovascular/hypertensive patients, supports the effectiveness of bedtime aspirin in reducing systolic and diastolic blood pressure compared to morning dosing. The results align with previous findings but distinguish themselves by incorporating a more diverse patient population and addressing moderate heterogeneity. While the study's outcomes are promising, further research, including larger sample sizes and longer durations, is warranted for comprehensive clinical implementation. As the study exclusively focused on aspirin timing, future investigations should explore sustained blood pressure effects in patients with clinical indications for aspirin alongside other hypertensive medications.
Evaluation of fractured carbonate reservoir and prediction of favorable areas in the eastern area of Amu Darya Right Bank
Authors: Li Yang , Cheng Xiaodong , Fan Leyuan , Sun Liguo , Wu Jiapeng , Wei Jiao
Published: October 2024

Fractured carbonate reservoirs are significantly developed in the eastern area of the Amu Darya Right Bank. However, their types, distributions, and fracture characteristics remain unclear. This uncertainty complicates reservoir prediction and hampers exploration and development processes. Given the strong correlation between fracture development and productivity, analyzing fractures is crucial. Comprehensive evaluation and prediction methods for fractured reservoirs are essential for advancing the oil and gas industry. Based on core and geological data analyses, it finds that these reservoirs exhibit low porosity and low to ultra-low permeability. By employing conventional logging alongside specialized methods, such as electrical imaging, nuclear magnetic resonance, and far detection logging, fractures and their effectiveness can be identified and evaluated, clarifying the characteristics of reservoir spaces. Constrained by the results from core and logging analyses, seismic single attribute analysis techniques is applied to predict fractures in the HX block of Amu Darya. To mitigate the limitations of single-attribute analysis, utilize a well-supervised BP neural network method for comprehensive fracture prediction. This multi-attribute approach increases the fracture prediction probability from less than 70%–72.7%. By integrating geological understanding and well logging, and considering the influence of lithology and structure on the reservoir, synthesize the fracture prediction results to optimally select favorable areas.
Mechanisms and salvage treatments in patients with multiple myeloma relapsed post-BCMA CAR-T cell therapy
Authors: Fu Bingjie , Liu Rui , Gao Gongzhizi , Lin Zujie , He Aili
Published: October 2024

Chimeric antigen receptor T-cell (CAR-T) therapy has ushered in a new era for the treatment of multiple myeloma (MM). Numerous clinical studies, especially those involving B-cell maturation antigen (BCMA)-directed CAR-T, have shown remarkable efficacy in patients with relapsed or refractory multiple myeloma (R/R MM). However, a considerable number of patients still experience disease recurrence or progression after BCMA CAR-T treatment, which is attributed to various factors, including antigen escape, CAR-T manufacturing factors, T cell exhaustion, inhibitory effects of tumor microenvironment and impact of prior treatments. The scarcity of effective treatment options following post-CAR-T disease recurrence, coupled with the lack of well-established salvage regimens, leaves patients who do relapse facing a bleak prognosis. In recent years, some academic institutions have achieved certain results in salvage treatments of patients with relapse after BCMA CAR-T treatment through secondary infusion of BCMA CAR-T, changing to non-BCMA-directed CAR-T, double-target CAR-T, bispecific antibodies or other novel therapies. This review summarizes the mechanisms of resistance or relapse after BCMA CAR-T administration and the available data on current salvage treatments, hoping to provide ideas for optimizing clinical salvage therapies.
Contribution of immunoglobulin products in influencing seasonal influenza infection and severity in antibody immune deficiency patients receiving immunoglobulin replacement therapy
Authors: Ballow Mark , Ortiz-de-Lejarazu Raúl , Quinti Isabella , Miller Matthew S. , Warnatz Klaus
Published: October 2024

Seasonal and pandemic influenza infection present a potential threat to patients with antibody deficiency. The acceptance and effect of the current recommendation for annual vaccination against influenza for patients with antibody deficiency is not well investigated and due to antigenic drift or shift the protective capacity of regular IgG replacement therapy (IgRT) is considered low. This narrative review considers the effect of influenza vaccination in immunodeficient patients and discusses available information on the effect of immunoglobulin products on seasonal influenza infectivity and severity in antibody deficiency patients receiving IgRT. The humoral immune response to seasonal influenza vaccination is reduced in patients with antibody immune deficiency. However, there is no evidence that the proportion of patients with primary antibody deficiency who develop influenza illness, and the severity of such illness, is increased when compared with the general population. The IgRT that patients receive has been shown to contain neutralizing antibodies as a consequence of past flu infections against both the hemagglutinin and neuraminidase surface proteins and other viral internal proteins of different influenza A virus strains. Studies have demonstrated not only significant levels of specific but also cross-reactive antibodies against seasonal influenza virus strains. Thus, despite the yearly changes in influenza viral antigenicity that occur, IgRT could potentially contribute to the protection of patients against seasonal influenza. Currently, only limited clinical data are available confirming a preventative effect of IgRT with respect to seasonal influenza infection. In conclusion, there is some evidence that IgRT could contribute to protection against seasonal influenza in patients with antibody-related immunodeficiency. However, additional clinical data are needed to confirm the extent and relevance of this protection and identify the main responsible virus targets of that protection.
Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site
Authors: Ihedioha Olivia C. , Marcarian Haley Q. , Sivakoses Anutr , Beverley Stephen M. , McMahon-Pratt Diane , Bothwell Alfred L. M.
Published: October 2024

Background

Host-related factors highly regulate the increased circulation of neutrophils during Leishmania infection. Platelet-derived Dickkopf-1 (DKK1) is established as a high-affinity ligand to LRP6. Recently, we demonstrated that DKK1 upregulates leukocyte-platelet aggregation, infiltration of neutrophils to the draining lymph node and Th2 differentiation during Leishmania infection, suggesting the potential involvement of the DKK1-LRP6 signalling pathway in neutrophil migration in infectious diseases.

Results

In this study, we further explored the potential role of DKK1-LRP6 signalling in the migration and longevity of activated neutrophils in the infection site using BALB/c mice with PMNs deficient in LRP6 (LRP6NKO) or BALB/c mice deficient in both PMN LRP6 and platelet DKK1 (LRP6NKO DKK1PKO). Relative to the infected wild-type BALB/c mice, reduced neutrophil activation at the infection site of LRP6NKO or LRP6NKO DKK1PKO mice was noted. The neutrophils obtained from either infected LRP6NKO or LRP6NKO DKK1PKO mice additionally showed a high level of apoptosis. Notably, the level of LRP6 expressing neutrophils was elevated in infected BALB/c mice. Relative to infected BALB/c mice, a significant reduction in parasite load was observed in both LRP6NKO and LRP6NKO DKK1PKO infected mice. Notably, DKK1 levels were comparable in the LRP6NKO and BALB/c mice in response to infection, indicating that PMN activation is the major pathway for DKK1 in promoting parasitemia. Parasite-specific components also play a crucial role in modulating neutrophil circulation in Leishmania disease. Thus, we further determine the contribution of Leishmania membrane components in the migration of neutrophils to the infection site using null mutants deficient in LPG synthesis (Δlpg1-) or lacking all ether phospholipids (plasmalogens, LPG, and GIPLs) synthesis (Δads1-). Relative to the WT controls, Δads1- parasite-infected mice showed a sustained decrease in neutrophils and neutrophil-platelet aggregates (for at least 14 days PI), while neutrophils returned to normal in Δlpg1- parasite-infected mice after day 3 PI.

Conclusion

Our results suggest that DKK1 signalling and Leishmania pathogen-associated molecular patterns appear to regulate the migration and sustenance of viable activated neutrophils in the infection site resulting in chronic type 2 cell-mediated inflammation.
Artificial intelligence for predicting treatment responses in autoimmune rheumatic diseases: advancements, challenges, and future perspectives
Authors: Yang Yanli , Liu Yang , Chen Yu , Luo Di , Xu Ke , Zhang Liyun
Published: October 2024

Autoimmune rheumatic diseases (ARD) present a significant global health challenge characterized by a rising prevalence. These highly heterogeneous diseases involve complex pathophysiological mechanisms, leading to variable treatment efficacies across individuals. This variability underscores the need for personalized and precise treatment strategies. Traditionally, clinical practices have depended on empirical treatment selection, which often results in delays in effective disease management and can cause irreversible damage to multiple organs. Such delays significantly affect patient quality of life and prognosis. Artificial intelligence (AI) has recently emerged as a transformative tool in rheumatology, offering new insights and methodologies. Current research explores AI’s capabilities in diagnosing diseases, stratifying risks, assessing prognoses, and predicting treatment responses in ARD. These developments in AI offer the potential for more precise and targeted treatment strategies, fostering optimism for enhanced patient outcomes. This paper critically reviews the latest AI advancements for predicting treatment responses in ARD, highlights the current state of the art, identifies ongoing challenges, and proposes directions for future research. By capitalizing on AI’s capabilities, researchers and clinicians are poised to develop more personalized and effective interventions, improving care and outcomes for patients with ARD.
Examining functional Near-Infrared Spectroscopy as a tool to study brain function in bilinguals
Authors: Pliatsikas Christos
Published: October 2024

There is increasing evidence that using more than one languages has significant effects on brain function. These effects have been observed in the developing, adult and aging brain, and have been suggested to have implications for cognitive and brain decline in bilinguals and multilinguals. Aside from extensive investigations with behavioral methods, such effects are now commonly investigated with functional neuroimaging methods, mostly functional Magnetic Resonance Imaging (fMRI) and electroencephalography (EEG). A relatively underused method in the field is functional Near-Infrared Spectroscopy (fNIRS), which carries several advantages over more established methods, including being appropriate for use with infants and children, but also with older and diseased samples. This paper provides an overview of the method and an account of how it has been used in the field of bilingual cognition. It concludes with suggestions of how the method can be best utilized in future research, highlighting it as a method with a strong potential for updating existing theories on the effects of bilingualism on brain function.