bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive genome assembly reveals genetic diversity and carcass consumption insights in critically endangered Asian king vultures
Authors: Buthasane Wannapol , Shotelersuk Vorasuk , Chetruengchai Wanna , Srichomthong Chalurmpon , Assawapitaksakul Adjima , Tangphatsornruang Sithichoke , Pootakham Wirulda , Sonthirod Chutima , Tongsima Sissades , Wangkumhang Pongsakorn , Wilantho Alisa , Thongphakdee Ampika , Sanannu Saowaphang , Poksawat Chaianan , Nipanunt Tarasak , Kasorndorkbua Chaiyan , Koepfli Klaus-Peter , Pukazhenthi Budhan S. , Suriyaphol Prapat , Wongsurawat Thidathip , Jenjaroenpun Piroon , Suriyaphol Gunnaporn
Published: April 2024

The Asian king vulture (AKV), a vital forest scavenger, is facing globally critical endangerment. This study aimed to construct a reference genome to unveil the mechanisms underlying its scavenger abilities and to assess the genetic relatedness of the captive population in Thailand. A reference genome of a female AKV was assembled from sequencing reads obtained from both PacBio long-read and MGI short-read sequencing platforms. Comparative genomics with New World vultures (NWVs) and other birds in the Family Accipitridae revealed unique gene families in AKV associated with retroviral genome integration and feather keratin, contrasting with NWVs’ genes related to olfactory reception. Expanded gene families in AKV were linked to inflammatory response, iron regulation and spermatogenesis. Positively selected genes included those associated with anti-apoptosis, immune response and muscle cell development, shedding light on adaptations for carcass consumption and high-altitude soaring. Using restriction site-associated DNA sequencing (RADseq)-based genome-wide single nucleotide polymorphisms (SNPs), genetic relatedness and inbreeding status of five captive AKVs were determined, revealing high genomic inbreeding in two females. In conclusion, the AKV reference genome was established, providing insights into its unique characteristics. Additionally, the potential of RADseq-based genome-wide SNPs for selecting AKV breeders was demonstrated.
Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer
Authors: Pfeifer Matthias , Brammeld Jonathan S. , Price Stacey , Pilling James , Bhavsar Deepa , Farcas Anca , Bateson Jessica , Sundarrajan Anjana , Miragaia Ricardo J. , Guan Nin , Arnold Stephanie , Tariq Laiba , Grondine Michael , Talbot Sarah , Guerriero Maria Lisa , O’Neill Daniel J. , Young Jamie , Company Carlos , Dunn Shanade , Thorpe Hannah , Martin Matthew J. , Maratea Kimberly , Barrell Daniel , Ahdesmaki Miika , Mettetal Jerome T. ,   Functional Genomics Centre, Brownell James , McDermott Ultan
Published: April 2024

Most lung cancer patients with metastatic cancer eventually relapse with drug-resistant disease following treatment and EGFR mutant lung cancer is no exception. Genome-wide CRISPR screens, to either knock out or overexpress all protein-coding genes in cancer cell lines, revealed the landscape of pathways that cause resistance to the EGFR inhibitors osimertinib or gefitinib in EGFR mutant lung cancer. Among the most recurrent resistance genes were those that regulate the Hippo pathway. Following osimertinib treatment a subpopulation of cancer cells are able to survive and over time develop stable resistance. These ‘persister’ cells can exploit non-genetic (transcriptional) programs that enable cancer cells to survive drug treatment. Using genetic and pharmacologic tools we identified Hippo signalling as an important non-genetic mechanism of cell survival following osimertinib treatment. Further, we show that combinatorial targeting of the Hippo pathway and EGFR is highly effective in EGFR mutant lung cancer cells and patient-derived organoids, suggesting a new therapeutic strategy for EGFR mutant lung cancer patients.
3D printed titanium carbide MXene-coated polycaprolactone scaffolds for guided neuronal growth and photothermal stimulation
Authors: Li Jianfeng , Hashemi Payam , Liu Tianyi , Dang Ka My , Brunk Michael G. K. , Mu Xin , Nia Ali Shaygan , Sacher Wesley D. , Feng Xinliang , Poon Joyce K. S.
Published: April 2024

The exploration of neural circuitry is paramount for comprehending the computational mechanisms and physiology of the brain. Despite significant advances in materials and fabrication techniques, controlling neuronal connectivity and response in 3D remains a formidable challenge. Here, we introduce a method for engineering the growth of 3D neural circuits with the capability for optical stimulation. We fabricate bioactive interfaces by melt electrospinning writing (MEW) 3D polycaprolactone (PCL) scaffolds followed by coating with titanium carbide (Ti3C2Tx MXene). Beyond enhancing hydrophilicity, cell adhesion, and electrical conductivity, the Ti3C2Tx MXene coating enables optocapacitance-based neuronal stimulation, induced by localized temperature increases upon illumination. This approach offers a pathway for additive manufacturing of neural tissues endowed with optical control, facilitating functional tissue engineering and neural circuit computation.
Interleaved TMS/fMRI shows that threat decreases dlPFC-mediated top-down regulation of emotion processing
Authors: Patel Milan , Teferi Marta , Gura Hannah , Casalvera Abigail , Lynch Kevin G. , Nitchie Frederick , Makhoul Walid , Sheline Yvette I. , Oathes Desmond J. , Balderston Nicholas L.
Published: April 2024

The dorsolateral prefrontal cortex (dlPFC) is thought to be a key site in the brain’s cognitive control network, supporting cognitive processes like attention and working memory [1–7]. There is also evidence that the dlPFC is engaged during anxiety regulation tasks, suggesting that anxiety regulation may be mediated in part by dlPFC activity [8–15]. However, the degree to which these two domains of processing overlap is unclear. Therefore, in the current study, we tested the hypothesis that the dlPFC regulates brain regions critical for the expression of anxiety. To do so, we used interleaved TMS/fMRI to record TMS-evoked BOLD responses during periods of threat compared to periods of safety. We hypothesized that TMS pulses would reduce activity in anxiety expression regions during threat. Forty-four healthy controls (no current or history of psychiatric disorders) were recruited to take part in a broader study. Participants completed the neutral, predictable, and unpredictable (NPU) threat task while receiving TMS pulses to either the right dlPFC or a control region. A whole brain analysis identified regions showing significant BOLD responses evoked by dlPFC stimulation. We then extracted these responses and compared those evoked during safe blocks to those evoked during unpredictable threat. We found that responses in the left insula (LI), right sensory/motor cortex (RSM), and a region encompassing the bilateral SMA regions (BSMA) showed significantly different responses during the safe blocks compare to the threat. During the safe periods, these regions showed significant BOLD deactivations. These deactivations were reduced during the threat blocks. Overall, these findings are largely consistent with the hypothesis that the dlPFC plays a role in the top-down control of emotion and suggest that dlPFC activity reduces downstream activity in emotional expression regions, but that this effect is reduced under threat.
Metalation of metal–organic frameworks: fundamentals and applications
Authors: Li Hai-Yu , Kong Xiang-Jing , Han Song-De , Pang Jiandong , He Tao , Wang Guo-Ming , Bu Xian-He
Published: April 2024

This review summarizes the recent research progress in the metalation of metal–organic frameworks, spanning the design principles, synthetic strategies, and potential applications.
Critical evaluation of current isolation, detection, and genotyping methods of Cryptosporidium species and future direction
Authors: Mahmudunnabi Rabbee G. , Kasetsirikul Surasak , Soda Narshone , Sallam Mohamed , Pannu Amandeep Singh , Nguyen Nam-Trung , Stratton Helen , Shiddiky Muhammad J. A.
Published: April 2024

Rapid detection and epidemiological monitoring are critical for preventing the spread of Cryptosporidium spp. and minimising public health risks. Techniques to isolate, quantify and genotype cryptosporidium are reviewed, along with future directions.
Metal–organic framework-based pH/NIR dual-responsive nanoparticles for combined photothermal/photodynamic therapy and chemotherapy of cancer
Authors: Huang Lihua , Luo Ying , Cong Yiyang , Liu Jia , Xu Caiyan , Zeng Zhaoxiang , Yin Yihua , Hong Hao , Xu Wenjin
Published: April 2024

Metal–organic framework-based pH/NIR dual-responsive nanoparticles for combined photothermal/photodynamic therapy and chemotherapy of cancer.
Exceptional behavior of a high-temperature superconductor in proximity to a ferromagnet in a bilayer film, La0.67Sr0.33MnO3/YBa2Cu3O7
Authors: Singh Ankita , Datta Sawani , Pandeya Ram Prakash , Kandukuri Srinivas C. , Bapat Rudheer , Parmar Jayesh , Maiti Kalobaran
Published: April 2024

We studied the electronic properties of a high-temperature superconductor in proximity to a ferromagnetic material in a bilayer film of La0.67Sr0.33MnO3 (LSMO)/YBa2Cu3O7 (YBCO).
Promoting H2 generation of BiFeO3 photocathodes by a catalyst-sensitizer dyad linked with Sn(dipicolinate)2
Authors: Yan Meiqi , Li Yingzheng , Liu Chang , Zhao Ziqi , Shan Yu , Li Fei , Sun Licheng , Li Fusheng
Published: April 2024

A catalyst-sensitizer dyad linked by the coordinated interaction between the pyridine-2,6-dicarboxylic group and Sn4+, and loaded on the BiFeO3 photocathode for light-driven H2 generation.
Gold carbonyl cations and beyond: homoleptic gold(i) complexes with P4 and P4S3 and the half-sandwich cation [Au(C6H6)(CO)]+
Authors: Schmitt Manuel , Nestle Sarah , Radtke Valentin , Krossing Ingo
Published: April 2024

An excellent synthon for a ‘naked’ Au+ salt, [Au(CO)2][F{Al(ORF)3}2], was synthesized in 1,2,3,4-tetrafluorobenzene with the synergistic Ag+/0.5 I2 system and used to generate the cations [Au(P4)2]+ and [Au(P4S3)2]+ as well as the novel half-sandwich complex [Au(C6H6)(CO)]+.
Large tensile-strained BaTiO3 films grown on a lattice-mismatched La-doped BaSnO3 bottom electrode
Authors: Gong Lizhikun , Marunouchi Ko , Chikamatsu Akira , Ohta Hiromichi , Katayama Tsukasa
Published: April 2024

A tensile strain of 2% was achieved in BaTiO3 films using La-doped BaSnO3 bottom electrodes. The ferroelectric-paraelectric phase transition temperature exceeds 400 °C.
Same size, same support, same spectator? Selective acetylene hydrogenation on supported Pd nanoparticles
Authors: Rötzer Marian D. , Krause Maximilian , Hinke Tobias , Bertrang Kevin , Schweinberger Florian F. , Crampton Andrew S. , Heiz Ueli
Published: April 2024

The selective hydrogenation of acetylene catalyzed by Pd nanoparticles is used in industry to increase the purity of ethylene. To enhance the reaction, the influence of different substrates, i.e. Pt(111) and Mo(211), for use with Pd supported on a-SiO2 thin films, was investigated.
Robust luminogens as cutting-edge tools for efficient light emission in recent decades
Authors: Jayabharathi Jayaraman , Thanikachalam Venugopal
Published: April 2024

Blue luminogens play a vital role in white lighting and potential metal-free fluorescent materials and their high-lying excited states contribute to harvesting triplet excitons in devices.
Angular-resolved Rabi oscillations of orthorhombic spins in a Co(ii) molecular qubit
Authors: Liao Yi-Qiu , Liu You-Chao , Wang Yi-Han , Fu Peng-Xiang , Xie Yi , Gao Song , Wang Ye-Xin , Liu Zheng , Jiang Shang-Da
Published: April 2024

Rabi oscillations with varying orientations of microwave magnetic field B1 for two anisotropic g-tensors with different orientations.
Ligand effect on Ru-centered species toward methane activation
Authors: Guo Mengdi , Wu Xiaonan , Wu Hechen , Sun Xiaoyan
Published: April 2024

Ligands have been known to profoundly affect the chemical transformations of methane, yet significant challenges remain in shedding light on the underlying mechanisms.
Control of the geometry and anisotropy driven by the combination of steric and anion coordination effects in CoII complexes with N6-tripodal ligands: the impact of the size of the ligand on the magnetization relaxation time
Authors: Landart Aritz , Quesada-Moreno María Mar , Palacios María A. , Li Yanling , Ozerov Mykhaylo , Krzystek J. , Colacio Enrique
Published: April 2024

Field-induced and hidden Co(ii) SIMs with N6-tripodal ligands exhibit size-dependent magnetic relaxation time.
Correction: Simple synthetic access to [Au(IBiox)Cl] complexes
Authors: Martynova Ekaterina A. , Zuccarello Marco , Kronenberg Domenic , Beliš Marek , Czapik Agnieszka , Zhang Ziyun , Van Hecke Kristof , Kwit Marcin , Baudoin Olivier , Cavallo Luigi , Nolan Steven P.
Published: April 2024

Correction for ‘Simple synthetic access to [Au(IBiox)Cl] complexes’ by Ekaterina A. Martynova et al., Dalton Trans., 2023, 52, 7558–7563, https://doi.org/10.1039/D3DT01357J.
Enhancement of the texture and microstructure of faba bean-based meat analogues with brewers' spent grain through enzymatic treatments
Authors: Fan Yue , Zheng Shiyu , Annamalai Pratheep K. , Bhandari Bhesh , Prakash Sangeeta
Published: April 2024

This study uses a low-energy enzymatic treatment to produce plant-based meat from faba bean protein and brewers' spent grain.
Revealing the ACE receptor binding properties and interaction mechanisms of salty oligopeptides from Stropharia rugosoannulata mushroom by molecular simulation and antihypertensive evaluation
Authors: Li Wen , Chen Wanchao , Wang Jinbin , Zhang Zhong , Wu Di , Liu Peng , Li Zhengpeng , Ma Haile , Yang Yan
Published: April 2024

The salty oligopeptides from Stropharia rugosoannulata have been proven to be potential ACE inhibitors.
Advancing sustainable lignin valorisation: utilizing Z-scheme photocatalysts for efficient hydrogenolysis of lignin's β-O-4, α-O-4, and 4-O-5 linkages under ambient conditions
Authors: Ghalta Rajat , Srivastava Rajendra
Published: April 2024

Z-Scheme photocatalysts for sustainable hydrogenolysis of β-O-4, α-O-4, and 4-O-5 linkages of lignin-derived ether in the selective production of aromatics or aliphatic hydrocarbons.
Current research status of ionic polymer–metal composites in applications of low-voltage actuators
Authors: Lai Jinguang , Zeng Bo , Liu Jiachen , Zhang Jianjun , Pei Wenle , Zhou Yi , Liu Yueming , Li Jungang , Tong Yang
Published: April 2024

Bending response images of an IPMC actuator under the same DC voltage and recovery process diagram after removing the voltage.
Role of polyvinylpyrrolidone in the polyol synthesis of platinum nanoparticles
Authors: Xin Yunzi , Nagata Taku , Kato Kunihiko , Xu Yuping , Shirai Takashi
Published: April 2024

Role of PVP in polyol synthesis of Pt NPs was clarified via investigation of the hydrodynamic size, solid-state size and morphology, crystal structure, surface chemical state of the synthesized Pt NPs, as well as the reducing dynamic of Pt cations.
Correction: Pickering emulsion templated proteinaceous microparticles as glutathione-responsive carriers for endocytosis in tumor cells
Authors: Jiang Weijie , Guan Xin , Liu Wei , Li Yunxing , Jiang Hang , Ngai To
Published: April 2024

Correction for ‘Pickering emulsion templated proteinaceous microparticles as glutathione-responsive carriers for endocytosis in tumor cells’ by Weijie Jiang et al., Nanoscale Horiz., 2024, 9, 536–543, https://doi.org/10.1039/D3NH00551H.
Pd single-atom decorated OMS-2 nanorod for efficient silane oxidation
Authors: Zhang Liping , Dai Xingchao , Li Teng , Liu Ce , Wang Bin , Li Guomin , Zhao Peiqing , Cui Xinjiang
Published: April 2024

Single Pd atom-anchored OMS-2 material was synthesized and exhibited excellent catalytic performance for silane oxidation with H2O. Note that Pd species was trapped into frameworks of OMS-2 by substituting Mn ions and formed strong Pd–O bonds.
A gram-scale synthesis of very-long chain polyunsaturated fatty acids (VLC-PUFAs)
Authors: Song Changqing , Wade Alex , Rainier Jon D.
Published: April 2024

Herein we describe gram scale syntheses of VLC-PUFA 32:6 n-3 and 34:6 n-3 in 6 synthetic steps in 40% yield from DHA.
Surface functionalization of metal–organic framework nanoparticle for overcoming biological barrier in cancer therapy
Authors: Oh Jun Yong , Sim Youjung , Yang Gyeongseok , Park Myoung-Hwan , Kim Kibeom , Ryu Ja-Hyoung
Published: April 2024

Surface modification of MOF particle for overcoming biological barriers.
Unveiling the surface hydroxylation and selenite modification of in situ generated nickel for promoting the hydrogen evolution reaction
Authors: Guo Kailu , Jia Jinzhi , Wang Huijiao , Xu Cailing
Published: April 2024

An electrochemical activation process for Ni–Se–O–H crystal has been found to produce a Ni/Ni(OH)2 heterostructure decorated with a small amount of SeO32−, exhibiting superior alkaline HER activity and durability.
Retraction: High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles
Authors: Taheri-Ledari Reza , Hashemi Seyed Masoud , Maleki Ali
Published: April 2024

Retraction of ‘High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles’ by Reza Taheri-Ledari et al., RSC Adv., 2019, 9, 40348–40356, https://doi.org/10.1039/C9RA08062G.
Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis
Authors: Do Yura , Yagi Mikako , Hirai Haruka , Miki Kenji , Fukahori Yukina , Setoyama Daiki , Yamamoto Masatatsu , Furukawa Tatsuhiko , Kunisaki Yuya , Kang Dongchon , Uchiumi Takeshi
Published: April 2024

Heart function is highly dependent on mitochondria, which not only produce energy but also regulate many cellular functions. Therefore, mitochondria are important therapeutic targets in heart failure. Abcb10 is a member of the ABC transporter superfamily located in the inner mitochondrial membrane and plays an important role in haemoglobin synthesis, biliverdin transport, antioxidant stress, and stabilization of the iron transporter mitoferrin-1. However, the mechanisms underlying the impairment of mitochondrial transporters in the heart remain poorly understood. Here, we generated mice with cardiomyocyte-specific loss of Abcb10. The Abcb10 knockouts exhibited progressive worsening of cardiac fibrosis, increased cardiovascular risk markers and mitochondrial structural abnormalities, suggesting that the pathology of heart failure is related to mitochondrial dysfunction. As the mitochondrial dysfunction was observed early but mildly, other factors were considered. We then observed increased Hif1α expression, decreased NAD synthase expression, and reduced NAD+ levels, leading to lysosomal dysfunction. Analysis of ABCB10 knockdown HeLa cells revealed accumulation of Fe2+ and lipid peroxides in lysosomes, leading to ferroptosis. Lipid peroxidation was suppressed by treatment with iron chelators, suggesting that lysosomal iron accumulation is involved in ferroptosis. We also observed that Abcb10 knockout cardiomyocytes exhibited increased ROS production, iron accumulation, and lysosomal hypertrophy. Our findings suggest that Abcb10 is required for the maintenance of cardiac function and reveal a novel pathophysiology of chronic heart failure related to lysosomal function and ferroptosis.
Multi‐mode converter control for linear generator‐based wave energy system
Authors: Ullah Md Imran , Döhler Jessica S. , de Albuquerque Vinicius M. , Forslund Johan , Boström Cecilia , Temiz Irina
Published: April 2024

The electrification of remote islands has long been a subject of research interest, primarily because of their historical reliance on fossil fuels, leading to a significant carbon footprint. Recent advancements in wave energy converters offer a promising avenue to make these islands more self‐sustainable while considerably reducing carbon emissions. However, the persistent issue of voltage dips due to weaker grids continues to pose a challenge. This study introduces a multi‐mode converter control strategy with the goal of electrifying remote islands, employing a linear generator‐based wave energy converter in a unified electrical model. Various scenarios, including voltage dips and mainland grid disconnection, are simulated using MATLAB/Simulink. The study demonstrates the converter's ability to transition swiftly and smoothly in response to these scenarios, ensuring an uninterrupted power supply. Furthermore, the analysis indicates that the power quality at the point of common coupling remains well within acceptable standards.
PDS 70 unveiled by star-hopping: Total intensity, polarimetry, and millimeter imaging modeled in concert
Authors: Wahhaj Z. , Benisty M. , Ginski C. , Swastik C. , Arora S. , van Holstein R. G. , De Rosa R. , Yang B. , Bae J. , Ren B.
Published: April 2024

Context. Most ground-based direct-imaging planet search campaigns use angular differential imaging that distorts the signal from extended sources, such as protoplanetary disks. In the case of the young system PDS 70, for which two planets were detected within the cavity of a protoplanetary disk, obtaining a reliable image of both planets and the disk is essential to understanding planet-disk interactions.

Aims. Our goals are to reveal the true intensity of the planets and disk without self-subtraction effects for the first time, search for new giant planets beyond separations of 0.1″, and to study the morphology of the disk shaped by two massive planets.

Methods. We present YJHK-band imaging, polarimetry, and spatially resolved spectroscopy of PDS 70 using near-simultaneous reference star differential imaging, also known as star-hopping. We created a radiative transfer model of the system to try to match the near-infrared imaging and polarimetric data within measurement errors. Sub-millimeter imaging data from ALMA were also modeled. Furthermore, we extracted the spectra of the planets and the disk and compared them

Results. With strong constraints, we find that the disk is quite flared, with a scale height of ∼15 at the outer edge of the disk at ∼90 au, similar to some disks in the literature. The gap inside ∼50 au is estimated to have ∼1 of the dust density of the outer disk. The northeast outer disk arc seen in previous observations is likely the outer lip of the flared disk. Abundance ratios of sub-micron, micron, and grains estimated by the modeling indicate a shallow grain-size index greater than −2.7, instead of the canonical –3.5. There is both vertical and radial segregation of grains. Planet c is well separated from the disk and has a spectrum similar to planet b, and it is clearly redder than the disk spectra. Planet c is possibly associated with the sudden flaring of the disk starting at ∼50 au. We found no new planets in the system. If we assume DUSTY models and an age of 5 Myr, this indicates no new planets more massive than 5 outside a 12 au separation.
Combined spin orientation and phase function of asteroids
Authors: Carry B. , Peloton J. , Le Montagner R. , Mahlke M. , Berthier J.
Published: April 2024

Context. Large sky surveys provide numerous non-targeted observations of small bodies of the Solar System. The upcoming LSST of the Vera C. Rubin Observatory will be the largest source of small body photometry in the next decade. With non-coordinated epochs of observation, colors – and therefore taxonomy and composition – can only be computed by comparing absolute magnitudes obtained in each filter by solving the phase function (evolution of brightness of the small body against the solar phase angle). Current models in use in the community (HG, HG12*, and HG1G2), however, fail to reproduce the long-term photometry of many targets due to the change in the aspect angle between apparitions.

Aims. We aim to derive a generic yet simple phase function model accounting for the variable geometry of the small bodies over multiple apparitions.

Methods. As a spinoff of the HG1 G2 model, we propose the sHG1G2 phase function model in which we introduce a term describing the brightness changes due to spin orientation and polar oblateness. We applied this new model to 13 245 908 observations of 122 675 Solar System objects (SSOs). These observations were acquired in the g and r filters with the Zwicky Transient Facility between November 1, 2019 and December 1, 2023. We retrieved them and implemented the new sHG1G2 model in FINK, a broker of alerts designed for the LSST.

Results. The sHG1G2 model leads to smaller residuals than other phase function models, providing a better description of the photometry of asteroids. We determined the absolute magnitude, H, and phase function coefficients (G1, G2) in each filter, the spin orientation (α0, δ0), and the polar-to-equatorial oblateness, R, for 95 593 SSOs, which constitutes about a tenfold increase in the number of characterized objects compared to the current census.

Conclusions. The application of the sHG1 G2 model to ZTF alert data using the FINK broker shows that the model is appropriate for extracting physical properties of asteroids from multi-band and sparse photometry, such as the forthcoming LSST survey.
Technology-Based financial management of batik Riau MSMEs
Authors: Purwati Astri Ayu , Suriyanti Linda Hetri , Desnelita Yenny , Sitompul Silvia Sari
Published: April 2024

The problem faced by Batik Riau MSMEs (Batik Candafa and Batik Bujang) is the lack of knowledge on how to keep financial records. Most of the financial recording is done manually and is very limited in its implementation. Therefore, training and mentoring on a good digital technology-based financial recording system can help Batik Riau MSMEs to sustain their existence. For this reason, this program has developed financial management training activities and a desktop-based financial management system to help Batik Riau MSMEs manage their finances effectively and efficiently. The methodology used in this activity is design, procurement, training and evaluation of activities. The activity results show some increase in the ability of MSME employees to make and understand cash flow statements, income statements, balance sheets and the accuracy of current financial records.
The development of “Archive Treasure” application for Universitas Negeri Surabaya library
Authors: Rahaju Pudji , Sumarti Titin , Widyati Diana , Ramadhani Humayyun Nabila
Published: April 2024

In the digital era, college libraries are increasingly paying attention to electronic archives. Many universities are starting to outsource existing important documents and store them in digital formats to make them easier to access and manage. Overall, the archives in the college library have a very important role in preserving history and understanding the development of universities and their surroundings. By managing archives properly and correctly in accordance with existing regulations, universities can enrich knowledge and strengthen their identity as educational institutions that have a rich cultural heritage. In general, the method used in making this information system uses the waterfall model and previously collected data by observation and interviews. This is done in order to support the creation of information systems. Following are the stages in the Waterfall model starting from gathering requirements, design, development, testing, deployment and maintenance. This research produces an information system that can enrich the archives that are managed and stored digitally, while also providing information about oral history.
Diversity of bacteria isolated from raw milk of Senduro goats
Authors: Trimulyono Guntur , Lisdiana Lisa , Asri Mahanani Tri , Nafidiastri Farah Aisyah , Dewi Putri Rosfiana , Lailiyyah Hidayatul
Published: April 2024

Goat’s milk is widely consumed because of its good nutrition. However, goat’s milk is also a good habitat for several types of bacteria that may affect the milk quality. Therefore, information concerning the bacteria’s total number and diversity is crucial. This research aimed to reveal the total number and diversity of bacteria in Senduro goat’s milk from three farms. Samples of raw goat’s milk were collected from each farm in a sterile container. Then, the enumeration of the bacteria’s number was done using the Total Plate Count (TPC) method. The total number of bacteria obtained from goat’s milk on farms 1, 2, and 3 were 1.5 x 102CFU/mL, 8.8 x 101CFU/mL, and 1.3 x 102CFU/mL, respectively. The morphological characteristics of the colonies showed the diversity of bacterial isolates in raw goat milk from the three farms. The three samples also shared several bacterial isolates with the same characteristics. It also can be concluded that the bacteria’s total number in goat’s milk from three farms is still acceptable and meets the standard. Identification of the group of each bacterial isolate is needed shortly to deepen our understanding of their role.
Mössbauer spectroscopy and its application to the chemical science
Authors: Nakashima Satoru
Published: April 2024

Mössbauer spectroscopy is a powerful tool to investigate the physical and chemical state of the solid material including Mössbauer nuclide. The mechanism of Mössbauer spectroscopy is nuclear energy is shifted and spit by the interaction of the nucleus and its surrounding electrons. Moreover, the hyperfine interaction reveals the chemical phenomena and physical states such as oxidation state, spin state, magnetic state, and nuclear radius change between ground and excited state using. Mössbauer spectroscopy could present basic chemical science including physics and environmental science of materials.
Utilisation of augmented reality technology in physics education: A bibliometric analysis and its impact on Sustainable Development Goals (SDGs)
Authors: Dawana Irgy Redityo , Prahani Binar Kurnia , Hariyono Eko , Ghofur Muhammad Abdul , Wibowo Firmanul Catur , Bunyamin Muhammad Abd Hadi
Published: April 2024

The utilization of Augmented Reality (AR) Technology is very interesting and should be applied and researched further. This study aims to investigate the trend of using AR technology in physics learning and its impact on SDGs in education, as well as provide recommendations to improve the application of AR in Physics education. The methods used in this research are literature reviews and Meta-Analyses (PRISMA), combined with bibliometric analysis using the Scopus database. The findings show that research on AR Physics Education has increased significantly over the past ten years. The most common document type is conference papers, with the most document sources from conference proceedings and the most country publication contribution in Indonesia. These findings highlight the importance of increasing research related to AR Physics Education to impact the achievement of Sustainable Development Goals (SDGs) because learning is closely related to the learning environment. Future research should be more explorative, especially in exploring the potential of AR for sustainable-based learning, which is supported by a learning environment as a supporter of sustainable and STEM-based learning to improve higher-order thinking Skills (HOTS) and physics problem-solving skills. With environmental and STEM-based approaches, physics learning can be relevant to the real world to achieve SDGs.
Directed graphs with lower orientation Ramsey thresholds
Authors: Barros Gabriel Ferreira , Cavalar Bruno Pasqualotto , Kohayakawa Yoshiharu , Mota Guilherme Oliveira , Naia Tássio
Published: April 2024

We investigate the threshold p⃗H = p⃗H (n) for the Ramsey-type property G(n, p) → ⃗H, where G(n, p) is the binomial random graph and G → ⃗H indicates that every orientation of the graph G contains the oriented graph ⃗ H as a subdigraph. Similarly to the classical Ramsey setting, the upper bound p⃗H ⩽ Cn−1/m2(⃗ H) is known to hold for some constant C = C( ⃗ H), where m2(⃗H) denotes the maximum 2-density of the underlying graph H of ⃗ H. While this upper bound is indeed the threshold for some ⃗H, this is not always the case. We obtain examples arising from rooted products of orientations of sparse graphs (such as forests, cycles and, more generally, subcubic {K3, K3,3}-free graphs) and arbitrarily rooted transitive triangles.
Risiken für Heranwachsende bei einer frühen Spezialisierung für eine
Sportart
Authors: Johnson Amanda
Published: April 2024

Ist es sinnvoll, Heranwachsende schon früh auf eine Sportart festzulegen? Sind Kinder, die sich von klein
auf spezialisiert haben, die späteren Sieger? Haben sie ein höheres Verletzungsrisiko? Oder scheitern sie
gar, weil sich ihr Körper schneller abnutzt? Amanda Johnson hat Antworten auf Fragen, die viele Eltern
und Trainer beschäftigen.
Neurogene, nicht-obstruktive Harnretention: Diagnose und Therapie
Authors: Kaufmann Albert , Leitner Lorenz
Published: April 2024

Die Ätiologie der neurogenen, nicht-obstruktiven Harnretention ist mannigfaltig. Neben zentralnervösen Erkrankungen kommen auch Erkrankungen des peripheren Nervensystems in Betracht. Die Restharnbildung kann zu erheblichen Problemen führen, die die Patient*innen in ihrem täglichen Leben enorm beeinflussen können. Nur eine differenzierte Diagnostik macht eine der Harnblasenfunktionsstörung und auch der Lebenssituation der Patient*innen angepasste Therapie möglich. Sowohl konservative als auch operative therapeutische Strategien stehen zur Verfügung, medikamentöse Therapieansätze treten in den Hintergrund.

Als kausale Therapie der Funktionsstörung sind insbesondere neuromodulative Verfahren geeignet. Wenn eine artifizielle Harnblasenentleerung notwendig wird, sollte der intermittierende Selbstkatheterismus wenn immer möglich einem Dauerkatheter vorgezogen werden.
Adherence in Hepatitis C Virus Treatment: What We Know
Authors: Flamm Steven L. , Mangia Alessandra
Published: April 2024

Although therapy with direct-acting antiviral (DAA) agents achieves high hepatitis C virus (HCV) cure rates and is forgiving of missed doses, certain patient populations, such as people who inject drugs (PWID), are often denied therapy because of a perceived high risk of nonadherence. However, a relationship between adherence to DAAs for various patient populations and efficacy has not been well defined. The lack of a standardized method for evaluating adherence complicates making comparisons between studies, making it difficult to develop and implement novel measures that may improve adherent behavior. Traditional methods for assessing adherence may overestimate medication adherence, while newer, technology-based methods may assist with accurately assessing and maintaining patient adherence to therapy. Data demonstrate that special populations of patients with HCV, such as PWID, can be successfully treated, with relatively high rates of sustained virologic response (SVR) despite less-than-optimal adherence. While rates of adherence, and subsequently SVR, can be improved, antiviral therapy should not be withheld because of fear of nonadherence. This article addresses medication adherence and forgiveness of DAA regimens, such as sofosbuvir/velpatasvir and glecaprevir/pibrentasvir, in different patient populations with HCV. Considerations in evaluating adherence in HCV therapy and available methods for assessing adherence are detailed.
Exploring the Two-Way Link between Migraines and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Authors: Wang Yang , Hu Xiaofang , Wang Xiaoqing , Li Lili , Lou Peng , Liu Zhaoxuan
Published: April 2024

Background The objective of this study is to utilize Mendelian randomization to scrutinize the mutual causality between migraine and venous thromboembolism (VTE) thereby addressing the heterogeneity and inconsistency that were observed in prior observational studies concerning the potential interrelation of the two conditions.

Methods Employing a bidirectional Mendelian randomization approach, the study explored the link between migraine and VTE, incorporating participants of European descent from a large-scale meta-analysis. An inverse-variance weighted (IVW) regression model, with random-effects, leveraging single nucleotide polymorphisms (SNPs) as instrumental variables was utilized to endorse the mutual causality between migraine and VTE. SNP heterogeneity was evaluated using Cochran's Q-test and to account for multiple testing, correction was implemented using the intercept of the MR-Egger method, and a leave-one-out analysis.

Results The IVW model unveiled a statistically considerable causal link between migraine and the development of VTE (odds ratio [OR] = 96.155, 95% confidence interval [CI]: 4.342–2129.458, p = 0.004), implying that migraine poses a strong risk factor for VTE development. Conversely, both IVW and simple model outcomes indicated that VTE poses as a weaker risk factor for migraine (IVW OR = 1.002, 95% CI: 1.000–1.004, p = 0.016). The MR-Egger regression analysis denoted absence of evidence for genetic pleiotropy among the SNPs while the durability of our Mendelian randomization results was vouched by the leave-one-out sensitivity analysis.

Conclusion The findings of this Mendelian randomization assessment provide substantiation for a reciprocal causative association between migraine and VTE within the European population.
The environmental impact of small-bowel capsule endoscopy
Authors: Pioche Mathieu , Cunha Neves Joao A. , Pohl Heiko , Lê Minh-Quyen , Grau Raphaelle , Dray Xavier , Yzet Clara , Mochet Mikael , Jacques Jérémie , Wallenhorst Timothée , Rivory Jérôme , Siret Nadège , Peillet Anne-Laure , Chevaux Jean-Baptiste , Mion François , Chaput Ulriikka , Jacob Philippe , Grinberg Daniel , Saurin Jean-Christophe , Baddeley Robin , Rodriguez de Santiago Enrique , Cottinet Pierre-Jean ,   and the Sustainability Committee of the French Endoscopy Society (SFED)
Published: April 2024

Introduction The environmental impact of endoscopy, including small-bowel capsule endoscopy (SBCE), is a topic of growing attention and concern. This study aimed to evaluate the greenhouse gas (GHG) emissions (kgCO2) generated by an SBCE procedure.

Methods Life cycle assessment methodology (ISO 14040) was used to evaluate three brands of SBCE device and included emissions generated by patient travel, bowel preparation, capsule examination, and video recording. A survey of 87 physicians and 120 patients was conducted to obtain data on travel, activities undertaken during the procedure, and awareness of environmental impacts.

Results The capsule itself (4 g) accounted for < 6 % of the total product weight. Packaging (43–119 g) accounted for 9 %–97 % of total weight, and included deactivation magnets (5 g [4 %–6 %]) and paper instructions (11–50 g [up to 40 %]). A full SBCE procedure generated approximately 20 kgCO2, with 0.04 kgCO2 (0.2 %) attributable to the capsule itself and 18 kgCO2 (94.7 %) generated by patient travel. Capsule retrieval using a dedicated device would add 0.98 kgCO2 to the carbon footprint. Capsule deconstruction revealed materials (e. g. neodymium) that are prohibited from environmental disposal; 76 % of patients were not aware of the illegal nature of capsule disposal via wastewater, and 63 % would have been willing to retrieve it. The carbon impact of data storage and capsule reading was negligible.

Conclusion The carbon footprint of SBCE is mainly determined by patient travel. The capsule device itself has a relatively low carbon footprint. Given that disposal of capsule components via wastewater is illegal, retrieval of the capsule is necessary but would likely be associated with an increase in device-related emissions.
Knowledge of Tobacco Cessation among Adult Patients Visiting a Rural Satellite Center: A Cross-Sectional Study
Authors: Abranches Sergio Atanazio Aurobindo Garcia , Bhat Supriya , Kumari Deesha , Shetty Sankalpa
Published: April 2024

The prevalence of all types of tobacco use among men has been reported to be high in most parts of India (generally exceeding 50%). Nearly 95 to 100% of tobacco users develop periodontal diseases that have a diminishing effect on oral health.

A structured paper-based self-administered questionnaire comprising 15 close-ended questions was formulated for the purpose of data collection for this cross-sectional survey and a sample size of 323 was estimated. Total enumeration sampling method was followed. A significant gender-wise and socioeconomic-status-wise difference was observed based on the form of tobacco used. In this cross-sectional study, 54 (16.7%) individuals began the habit before the age of 15 years, of which 14.2% of the individuals used the smoked variant and 2.4% of the individuals used the smokeless variant of tobacco.

Total 265 (82%) individuals were aware that the habit was injurious to their health, of which 90% males and 86.4% females were aware of the harmful effects of the habit. While the awareness among the upper socioeconomic group was higher, the lower socioeconomic group displayed a lower level of awareness.

To advocate effective tobacco cessation programs, understanding the dependence on tobacco habit and their knowledge and attitude toward quitting tobacco plays a major role. Hence the present study was conducted with an objective to assess the knowledge and attitude of the patients toward tobacco cessation.
Social Disadvantage and Inequity in Access to Pediatric Critical Care Services for Children Living Remote from a Children's Hospital
Authors: Klein Jordan L. , Spaeder Michael C. , Doshi Ayush , Fang Gary Y. , Carver Deborah Jeannean
Published: April 2024

Regionalization of health care has created geographical distance between pediatric specialty services and children, with the potential for disparities in access to care. We investigated the association of state-level area deprivation index (S-ADI), a measure of socioeconomic disadvantage, and characteristics and outcomes in a cohort of children requiring unplanned hospital transfer to a quaternary care pediatric intensive care unit (PICU). We conducted a single-center retrospective cohort study of children requiring unplanned hospital transfer to the PICU at the University of Virginia Children's Hospital from July 1, 2019 to December 31, 2020, excluding planned transfers, transfers from another intensive care unit, and patients whose address could not be associated with an S-ADI. We collected demographic and clinical data as well as the S-ADI, an ordinal variable ranging from 1 to 10 with 10 representing the most disadvantage. We observed no differences in S-ADI based on patient sex, age, history of chronic medical conditions, or need for a medical device (tracheostomy, home ventilator, surgical feeding tube, cerebrospinal fluid shunt). We also did not observe differences in PICU or hospital length of stay based on S-ADI. We did observe for every one-point increase in S-ADI there was an associated increase of 8.6 miles (p < 0.001) in patient travel distance. Among patients from a higher S-ADI area, we observed increased severity of illness on PICU admission (p = 0.02) and case fatality as compared with patients from a lower S-ADI area (11 vs. 1.9%, p = 0.038). Children traveling the farthest for subspeciality pediatric critical care at our hospital had higher measures of socioeconomic disadvantage and severity of illness.
Recurrence analysis of meteorological data from climate zones in India
Authors: John Bejoy Joshin , Ambika G.
Published: April 2024

We present a study on the spatiotemporal pattern underlying the climate dynamics in various locations spread over India, including the Himalayan region, coastal region, and central and northeastern parts of India. We try to capture the variations in the complexity of their dynamics derived from temperature and relative humidity data from 1948 to 2022. By estimating the recurrence-based measures from the reconstructed phase space dynamics using a sliding window analysis on the data sets, we study the climate variability in different spatial locations. The study brings out the variations in the complexity of the underlying dynamics as well as their heterogeneity across the locations in India. We find almost all locations indicate shifts to more irregular and stochastic dynamics for temperature data around 1972–79 and shifts back to more regular dynamics beyond 2000. These patterns correlate with reported shifts in the climate and Indian Summer Monsoon related to strong and moderate El Niño–Southern Oscillation events and confirm their associated regional variability.
Hole and positron interaction with vacancies and p-type dopants in epitaxially grown silicon
Authors: Isa Fabio , Schmidt Javier A. , Aghion Stefano , Napolitani Enrico , Isella Giovanni , Ferragut Rafael
Published: April 2024

The concentration of vacancies and impurities in semiconductors plays a crucial role in determining their electrical, optical, and thermal properties. This study aims to clarify the nature of the interaction between positrons and ionized p-type impurities, emphasizing the similarities they share with the interaction between holes and this type of impurity. An overall strategy for investigating defects in semiconductor crystals that exhibit a combination of vacancies and p-type impurities is presented. By using positron annihilation spectroscopy, in particular, Doppler broadening of the annihilation radiation, we quantify the concentration of vacancies in epitaxial Si crystals grown by low-energy plasma-enhanced chemical vapor deposition. The vacancy number densities that we find are (1.2 ± 1.0) × 1017 cm−3 and (3.2 ± 1.5) × 1020 cm−3 for growth rates of 0.27 and 4.9 nm/s, respectively. Subsequent extended annealing of the Si samples effectively reduces the vacancy density below the sensitivity threshold of the positron technique. Secondary ion mass spectrometry indicates that the boron doping remains unaffected during the annealing treatment intended for vacancy removal. This study provides valuable insights into the intricate interplay between vacancies and ionized impurities with positrons in semiconductor crystals. The obtained results contribute to advance the control and understanding of material properties in heterostructures by emphasizing the significance of managing vacancy and dopant concentrations.