bluuebunny/crossref_metadata_2025 huggingface dataset:
Gambaran Tahapan pada Individu dengan Trauma Masa Kecil di Kecamatan Matraman, Jakarta Timur
Authors: Syamil Syamil , Susilarini Tanti
Published: October 2024

Tujuan dari penelitian ini adalah khususnya dalam bidang psikologi, penelitian ini merepresentasikan forgiveness dari perspektif individu yang memiliki trauma, dan untuk menggalimakna yang lebih dalam terkait memaafkan dan bagaimana individu melakukan proses forgivenesssecara bertahap serta merubah dampak negatif menjadi dampak positif . Pengalaman traumatisyang terjadi dalam kehidupan seseorang bisa menjadi catatan sejarah yang hitam. Lukapsikologis terkadang terasa perih ketika diungkap kembali. Namun, dengan melakukanforgiveness dapat memberikan peluang yang besar untuk menuju hidup yang lebih positif.Memaafkan dapat diartikan dengan melepaskan luka yang dialami. Forgiveness dilakukan dengantujuan untuk menyembuhkan diri sendiri dan memberi kesempatan kepada orang yangmenyebabkan rasa sakit untuk dapat membangun kembali hubungan yang lebih sehat danbahagia. Sebaliknya, apabila pemaafan tidak dilakukan dapat menjadi pemicu tumbuhnyakemarahan, kebencian, dendam yang berkepanjangan, juga dapat menimbulkan sakit secara fisikmaupun mental. Penelitian kualitatif yang menggunakan pendekatan deskriptif ini membahastentang esensi dari forgiveness sebagai salah satu cara untuk menciptakan kebahagiaan dalmammenjalani hidup.
Pengaruh Media Sosial TikTok dan Regulasi Emosi Terhadap Perubahan Suasana Hat
Authors: Adinda Maurael , Indrawati Erdina
Published: October 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pengguna media sosial Titok dan Regulasi emositerhadap suasana hati pada siswa kelas XI SMA Hutama Bekasi. Penelitian ini menggunakan metodekuantitatif. Populasi pada penelitian ini berjumlah 242 dengan sampel berjumlah 149 respondendengan Teknik pengambilan sampel simple random sampling. Metode pengumpulan datamenggunakan model skala likert. Pengolahan data pada penelitian ini dianalisis denganmenggunakan metode Regresi Linear Sederhana dan Regresi Linear Berganda melalui programJASP 0.18.3.0 for windows. Hasil penelitian menunjukan bahwa 1) terdapat pengaruh media sosialTikTok terhadap perubahan suasana hati ( r = 0.325 dan p = 0.001 < 0,05); 2) terdapat pengaruhregulasi emosi terhadap perubahan suasana hati ( r = 0.582 dan p = 0.001 < 0,05); 3) terdapatpengaruh media sosial TikTok dan Regulasi Emosi terhadap perubahan suasana hati ( r = 0.682 danp = 0.001 < 0,05). Hal ini menunjukkan bahwa terdapat pengaruh media sosial TikTok dan regulasiemosi terhadap perubahan suasana hati siswa kelas XI SMA Hutama Bekas
Implementasi Algoritma Multi-Factor Evaluation Process Pada Website Sistem Pendukung Keputusan Minat Siswa
Authors: Pratama Fajar , Widodo Agung Mulyo
Published: October 2024

After graduating from high school, students often have difficulty in determining the right major.The challenges faced include the lack of clear guidelines and criteria in choosing a major, as wellas the selection process which is still traditional and subjective. To overcome these obstacles, thisarticle suggests the implementation of a website-based Decision Support System (DSS) using theMulti-Factor Evaluation Process (MFEP) algorithm. This DSS was developed to help studentschoose a major that suits their interests and potential. The methods used in this study includeliterature studies, observations, interviews, and questionnaires. The results of the study indicatethat the use of a web-based DSS with the MFEP algorithm is able to provide more effective andobjective recommendations in helping students choose a major.
Implementasi ERP Odoo Modul Point of Sale untuk Meningkatkan Operasional Ritel di Toko Ezie
Authors: Irmayanti Ade , Wulandari Niken , Soraya Ayu
Published: October 2024

Toko Ezie, a retail business in Nanga Bulik, Lamandau Regency, Central Kalimantan, specializesin selling furniture, household appliances, and bedroom accessories. Established in 2010, TokoEzie still manages its operations manually, particularly in sales recording, inventory management,and financial tracking. This manual system causes problems such as data inconsistency, recordingerrors, and operational inefficiencies. This research aims to analyze the requirements and benefitsof implementing an Enterprise Resource Planning (ERP) system, specifically the Point of Sale(POS) module, to improve Toko Ezie's operational efficiency and effectiveness. This study uses aqualitative descriptive approach with a case study method. Data were collected throughinterviews, observations, and documentation from the owner and staff of Toko Ezie. The researchfindings indicate that the implementation of an Odoo-based ERP system in the POS module willautomate sales processes, monitor stock in real-time, and streamline financial recording. Theintegration between the POS, inventory, and financial modules is expected to minimize manualerrors, improve data accuracy, and optimize customer service. This ERP implementation isanticipated to provide a long-term solution for enhancing the business performance of Toko Ezie.
NutriCare: Aplikasi Pemantau Gizi Ibu Hamil untuk Menghindari Stunting dengan Memenuhi Kebutuhan Kalori dan Zat Besi
Authors: Maharani Tarisyah Puan , Budhisantoso Nugroho
Published: October 2024

Stunting in children under five, due to chronic malnutrition since in the womb, has an impact onchildren's health and cognitive development as well as the potential for long-term economic losses.In Indonesia, the prevalence of stunting will reach 21.6% in 2022. Iron and calorie deficiency inpregnant women is the main factor causing stunting, with 48.6% of pregnant women experiencinganemia. Many pregnant women lack easily accessible nutritional information. The Hilda AlnairaClinic in Koja, North Jakarta, faces challenges in providing manual nutritional recommendationsthat are inefficient and lack personalization. This research aims to develop the "NutriCare" mobileapplication to help pregnant women monitor calorie and iron intake. This Android-basedapplication was developed using a prototypemethod, easy-to-use interface, relevant features, testedusing the black box method, and optimized before full implementation. This application helpsincrease pregnant women's understanding of nutrition and supports maternal health and fetaldevelopment in efforts to prevent stunting.
Pengembangan Antarmuka Pengguna (User Interface) Sistem Pengelolaan Beasiswa Berbasis Website dengan Pendekatan Cognitive Walkthrough
Authors: Tasya Selviana , Setyantoro Dwipo
Published: October 2024

An effective user interface (UI) is crucial in a web-based scholarshipmanagement system to ensure a good user experience and easy accessibility toinformation. However, many users still encounter difficulties using the existingsystem, necessitating a better design. This study aims to evaluate and improve theuser interface of the scholarship management system using the CognitiveWalkthrough approach. The Cognitive Walkthrough approach is used to identifyusability issues in the user interface. A prototype of the design solution was thentested through usability testing involving seven evaluators and five different taskscenarios using Maze. The results show that all evaluators were able to completethe task scenarios with a category 1 rating (no issues), although four evaluators experienced minor issues in task scenarios 1 and 2. Evaluators were slightlyconfused when searching for the latest requirements information and the ineffectiveuse of buttons. By implementing the suggested improvements based on the findingsfrom the Cognitive Walkthrough, the user interface in the scholarship managementsystem can be significantly enhanced, facilitating users in accessing the requiredinformation.
Optimalisasi Operasional Layanan dan Integrasi Sistem pada Arsitektur Perusahaan PT X melalui Penerapan TOGAF ADM
Authors: Benedicta Laurence , Aprikasari Manda , Rachmatsyah Agus Dendi , Atmojo Wahyu Tisno
Published: October 2024

This research discusses the application of the TOGAF ADM method in modelling X Ltd,which operates in the field of printing and book publishing services. X Ltd facesoperational challenges that are still manual and not fully integrated with the system sothat the service operational process becomes ineffective in terms of time. This researchaims to design an integrated architecture, including business process architecture,application and data architecture, and technology architecture. The research method usesa qualitative approach by conducting interviews with two sources from X Ltd to analyzecurrent operations. The results show that TOGAF ADM can help X Ltd Optimizes itsoperational system, accelerates data management, publishing books, and improvingcustomer service, and facilitating adaptation to changes through new system architecturemodelling.
Pengukuran Tingkat Kepuasan Pengguna E-Learning Menggunakan Model End User Computing Satisfaction (EUCS) di Universitas Esa Unggul
Authors: Yulianti Silvia , Widayanti Riya
Published: October 2024

Universitas Esa Unggul menjadi salah satu perguruan tinggi yang telah mengimplementasikan e-learning. Namun dalam penggunaannya, berdasarkan hasil kuesioner pra-penelitian, mahasiswa kerap mendapati kendala, seperti terjadinya gagal login, error saat submit tugas, loading time lama, error saat mengerjakan quiz , server down. Setelah e-learning, mengetahui keberhasilan dari implementasi sistem tersebut menjadi hal penting bagi Universitas Esa Unggul. Salah satu faktor suatu sistem dapat dikatakan berhasil, dapat dilihat dari kepuasan pengguna akhirnya. Peneliti menggunakan Model End User Computing Satisfaction (EUCS), yang memiliki lima dimensi dalam mengukur kepuasan pengguna akhir yaitu content, format, timeliness, ease of use, dan accuracy. Sebanyak 100 responden yang merupakan mahasiswa aktif yang menggunkan e-learning menjadi sampel penelitian ini. Peneliti melakukan analisis data menggunakan pendekatan Partial Least Square Structural Equation Modeling (PLS-SEM) dengan bantuan software aplikasi SmartPLS 4.0. Berdasarkan hasil penelitian ini, dari kelima hipotesis terdapat dua hipotesis ditolak dengan nilai t-test dibawah ambang batas (1,96) dan tiga hipotesis diterima. Sehingga dapat disimpulkan variabel content, accuracy tidak memberikan pengaruh yang signifikan, dan variabel format, ease of use, timeliness memberikan pengaruh yang signifikan terhadap kepuasan pengguna e-learning Universitas Esa Unggul.Kata kunci :
HUBUNGAN ANTARA OPTIMISME DAN DUKUNGAN SOSIAL TEMAN SEBAYA DENGAN RESILIENSI PADA MAHASISWA TINGKAT AKHIR YANG SEDANG MENJALANI SKRIPSI DI STIKES HANGTUAH TANJUNGPINANG KEPULAUAN RIAU
Authors: Widyanti Kania , Tatiyani Tatiyani
Published: October 2024

Tujuan dari penelitian ini adalah untuk mengetahui ada Hubungan antara Optimisme danDukungan sosial teman sebaya terhadap Resiliensi pada mahasiswa akhir yang sedangmenjalani skripsi di STIKES Hang Tuah Tanjungpinang Kepulauan Riau. Penelitian inimerupakan penelitian kuantitatif. Populasi dari jumlah siswa terdaftar sebanyak 77 mahasiswatingkat akhir yang sedang menjalani skripsi dan merupakan jumlah sampel dari penelitian.Pengumpulan data menggunakan skala likert dan pengambilan sampel menggunakannonprobability sampling dengan menggunakan teknik sampel jenuh. Hasil penelitianmenunjukkan bahwa terdapat hubungan dengan arah positif yang signifikan antara optimismedan resiliensi sebesar r = 0,686 dan p = < 0,05 dan terdapat hubungan dengan arah positif yangsignifikan antara dukungan sosial teman sebaya dengan resiliensi sebesar r = 0,485 dan p = <0,05. Selanjutnya, hasil analisis data dengan multivariate correlation menggunakan SPSS 29.0for windows diperoleh koefisien determinasi R square sebesar 0,493 dan berdasarkan regresikorelasi multivariat diperoleh nilai koefisien korelasi R = 0,702 dan p = <0,001 yang berartiterdapat hubungan antara optimisme dan dukungan sosial teman sebaya terhadap resiliensipada mahasiswa tingkat akhir yang sedang menjalani skripsi di STIKES Hang TuahTanjungpinang Kepulauan Riau.
HUBUNGAN ANTARA KONFLIK KERJA KELUARGA DAN EFIKASI DIRI DENGAN KELELAHAN KERJA PADA PERAWAT DI RUMAH SAKIT MEDISTRA JAKARTA
Authors: Putri Kamila Mufliha , Tatiyani Tatiyani
Published: October 2024

Penelitian kuantitatif ini bertujuan untuk menguji hubungan antara konflik kerja keluarga dan efikasi diridengan kelelahan kerja pada perawat di Rumah Sakit Medistra Jakarta. Kelelahan kerja adalah variabelterikat, sedangkan konflik kerja keluarga (X1) dan efikasi diri (X2) adalah variabel bebas. Metodepengambilan sampel menggunakan metode purposive sampling dengan sampel sebanyak 157 orang perawatwanita yang sudah menikah dan memiliki anak yang bekerja di Rumah Sakit Medistra Jakarta. Hasil analisisdata variabel konflik kerja keluarga dan kelelahan kerja menunjukkan koefisien korelasi korelasi r =0,793 with p = 0,000 < 0,005 yang menunjukkan ada hubungan positif antara keduanya. Hasilanalisis data menggunakan bivariate correlation, menunjukan bahwa ada hubungan negatifsignifikan antara efikasi diri dengan kelelahan kerja memiliki nilai koefisien korelasi r = -0,273dengan p = 0,001 < 0,005 yang menunjukkan bahwa ada hubungan yang negatif antara keduanya.Hasil uji analisis data menggunakan multivariate correlation, diperoleh nilai R sebesar 0,653 dan p= 0,000 < 0,05 hal ini menunjukkan ada hubungan signifikan antara konflik kerja keluarga danefikasi diri dengan kelelahan kerja. Sumbangan efektif konflik kerja keluarga dan efikasi diri dengankelelahan kerja sebesar 65,3% sementara sisanya 34,7% merupakan sumbangan dari faktor lain yangtidak diteliti dalam penelitian ini.
KUALITAS HIDUP PADA PASIEN ANSIETAS DITINJAU DARI TERAPI NEUROFEEDBACK DAN DUKUNGAN SOSIAL DI RSJ MARZOEKI MAHDI
Authors: Hasna Kamilah Claresta , Sovitriana Rilla
Published: October 2024

Penelitian ini bertujuan untuk membandingkan kualitas hidup ditinjau dari pasien ansietas yang diberitreatment neurofeedback dan yang tidak diberi treatment neurofeedback serta menguji hubungandukungan sosial dengan kualitas hidup pasien ansietas di RSJ Marzoeki Mahdi Bogor. Populasipenelitian ini adalah pasien ansietas yang dirawat di RSJ Marzoeki Mahdi Bogor. Sampel dalampenelitian ini terdiri dari dua kelompok, yaitu pasien yang menerima treatment neurofeedback danpasien yang tidak menerima treatment neurofeedback, dengan teknik purposive sampling. Datadikumpulkan menggunakan skala Likert untuk mengukur kualitas hidup dan dukungan sosial. Adaperbedaan perbedaan dari kualitas hidup ditinjau dari pasien ansietas yang mendapat treatmentneurofeedback dan yang tidak di RSJ Marzoeki Mahdi. Berdasarkan hasil analisa data penelitiandiperoleh (t) sebesar 09,279 dan p < 0,05. Artinya, bahwa pasien ansietas yang mendapat terapineurofeedback akan memiliki kualitas hidup yg baik. Ada hubungan dukungan sosial dengan kualitashidup pada pasien ansietas di RSJ Marzoeki Mahdi Bogor, maka diperoleh r sebesar 0,978 dan p < 0,05.Artinya, semakin tinggi dukungan sosial yang diterima pasien maka semakin baik kualitas hidup pasienansietas yang didapat.
ESTUDO RETROSPECTIVO SOBRE A EPIDEMIOLOGIA E AS SITUAÇÕES DE RISCO PARA INFECÇÃO HUMANA POR LEPTOSPIRA.SPP EM TRÊS REGIÕES DE SAÚDE DO ESTADO DO PARÁ
Authors: Santos André Roberto de Oliveira , Silva Andréia Ferreira da , Silva Matheus Moraes
Published: October 2024

Objetivo: Neste trabalho foram avaliadas características epidemiológicas e as principais situações de risco associadas aos casos confirmados nas três Regiões de Saúde com maior ocorrência da doença no estado do Pará, no período de 2007 a 2022. Métodos: Estudo epidemiológico retrospectivo e descritivo, utilizando dados secundários do Sistema de Informação de Agravos de Notificação sobre a ocorrência da doença. As variáveis analisadas foram: critério de diagnóstico da doença, sexo, idade (categorizada a cada 10 anos de idade), escolaridade (considerando o nível de estudo completo e incompleto da mesma categoria), zona de residência do paciente, ambiente de infecção, situações de risco e ocupação dos pacientes. Realizou-se estatística descritiva através do software Jamovi. Resultados: Dos 10.608 casos suspeitos, 17,08% (n=1.812) foram confirmados com leptospirose. Entre as 13 Regiões de saúde do estado, destacaram-se as regiões Metropolitana I com 57,28% dos casos, Metropolitana III com 11,15% e Baixo Amazonas com 8,61%. Conclusão: Nas três Regiões de Saúde com maior ocorrência da doença, a leptospirose acometeu principalmente, homens com ensino fundamental, residentes em áreas urbanas, com o domicílio como local provável de infecção, e o contato com local com sinais de roedores, que foi a principal situação de risco. É necessária a implementação de políticas públicas sociais e de saúde mais eficazes contra a leptospirose humana, assim como destacamos a importância do correto preenchimento das informações para garantir análises mais representativas da realidade da doença no estado.
ANÁLISE DO PERFIL EPIDEMIOLÓGICO DA HANSENÍASE NO ESTADO DE GOIÁS ENTRE 2018 E 2023
Authors: Santos Flora , Rezende Gabriela , Souza Mírian Eugênia , De Paula Gisele , Neves Ana Júlia , Neiva Elisa
Published: October 2024

Objetivo: Avaliar o perfil epidemiológico da hanseníase no estado de Goiás entre 2018 e 2023. Métodos: é um estudo observacional analítico de corte transversal no qual os dados foram extraídos do Sistema de Informação de Agravos de Notificação (SINAN). Resultados e discussão: foram relatados 7.420 casos de hanseníase no estado dos quais observou-se prevalência do sexo masculino, pardos e hanseníase do tipo multibacilar. Conclusão: percebe-se uma alta correlação principalmente entre sexo e raça no perfil epidemiológico da doença no estado. A alta prevalência da hanseníase multibacilar alerta para a necessidade de aperfeiçoamento das técnicas de busca ativa, conscientização, instrução populacional e diagnóstico.
ASSISTÊNCIA E MANEJO DE CUIDADOS DE CRIANÇAS COM TRANSTORNO DO ESPECTRO DO AUTISMO
Authors: DUARTE I , ALMOHALHA L
Published: October 2024

Objetivo: Compreender como cuidadores de crianças com condições crônicas de saúde, de curso constante, faziam a assistência e o manejo dos cuidados de crianças com transtorno do espectro do autismo. Métodos: Pesquisa de campo, transversal, exploratória, descritiva, de abordagem quantitativa com cuidadores das crianças com autismo com idades de 0 a 7 anos que frequentavam um núcleo de pesquisa e um ambulatório pediátrica de uma universidade federal da região do Triângulo Mineiro. Os dados foram coletados via questionário sociodemográfico elaborado pelas pesquisadoras e por dois instrumentos adaptados culturalmente para o Brasil: Family Management Measure (FAMM) e Inventário de Avaliação Pediátrica de Incapacidade (PEDI). Os dados foram plotados nas tabelas dos instrumentos e apresentados conforme escores brutos, normativos e contínuos para autocuidado, mobilidade e função social (PEDI) e classificação de concordância total, parcial ou discordância total (FAMM). Resultados/Discussão: Participaram 6 mães de meninos com autismo idade mínima de 4 anos e 7 meses e máxima de 5 anos e 11 meses. Com exceção de um participante, na área de mobilidade, todos os demais apresentaram desempenho significativamente inferior ao esperado pelo escore normativo da PEDI nos domínios avaliados das habilidades funcionais. Com relação a assistência do cuidador, foi possível observar que as crianças estavam recebendo mais ajuda dos seus cuidadores do que realmente precisavam. Os resultados do FAMM evidenciaram dificuldade de adequar a atividade de cuidar da condição da criança na rotina familiar, bem como a interferência da condição no relacionamento da família e a instabilidade em lidar quando algo inesperado acontece relacionado a condição da criança. Conclusão: Condições crônicas de curso constante como o TEA impactam o desempenho infantil, a quantidade de assistência oferecida pelo cuidador e o manejo dos cuidados ofertados à criança autista.
Pengaruh Kinerja Enviromental, Social, and Governance (ESG) dan Volatilitas Laba terhadap Volatilitas Harga Saham Syariah dengan Effective Tax Rate sebagai Variabel Moderasi (Studi Empiris pada Perusahaan yang terdaftar di Jakarta Islamic Index 70 periode Tahun 2018-2023)
Authors: Hasanah Nur , Adrianto Fajri , Hamidi Masyhuri
Published: October 2024

Penelitian ini bertujuan untuk mengeksplorasi pengaruh kinerja ESG (Environmental, Social, and Governance) baik secara agregat maupun secara parsial serta volatilitas laba terhadap volatilitas harga saham. Metode penelitian yang digunakan adalah metode kuantitatif. Data yang digunakan dalam penelitian ini adalah data sekunder berupa laporan keuangan dari website (www.idx.co.id) dan Refinitiv Eikon Database. Populasi pada penelitian ini adalah semua perusahaan yang terdaftar di Jakarta Islamic Index 70 (JII70) pada tahun 2018-2023. Sampel dipilih dari metode purposive sampling dan mendapatkan sampel 37 perusahaan dari beberapa kriteria yang telah ditetapkan. Jenis data penelitian ialah data Unbalanced Panel.Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi panel dengan bantuan EVIEWS versi 10. Hasil penelitian Variabel ESG Score (X1) berpengaruh negatif signifikan terhadap volatilitas harga saham. Variabel kinerja lingkungan (X1a) berpengaruh negatif signifikan terhadap volatilitas harga saham. Variabel kinerja sosial (X1b) berpengaruh positif signifikan. Variabel kinerja tata kelola (X1c) tidak berpengaruh terhadap volatilitas harga saham. Variabel volatilitas laba (X2) tidak berpengaruh terhadap volatilitas harga saham. Serta Variabel Effective tax rate dapat memperlemah pengaruh negatif pengungkapan ESG terhadap volatilitas harga saham.
Physalis Angulata: uma descrição sobre seus metabólitos secundários e efeitos farmacológicos
Authors: Silva Karina Araújo da , Mendonça Larissa Aguiar de
Published: October 2024

Introdução: A Physalis Angulata, conhecida popularmente como camapu, é uma planta medicinal de grande interesse para a comunidade científica. Originária da Líbia, essa espécie tem sido amplamente estudada por suas propriedades terapêuticas, como ação anti-inflamatória, analgésica e anticancerígena. Objetivo: Descrever os metabólitos secundários e os efeitos farmacológicos da Physalis Angulata. Método: Revisão de literatura descritiva, com levantamento dos artigos no PubMed, Google Scholar e CrossRef, as palavras-chaves para a busca foram Physalis Angulata, Camapu, Metabólitos secundários, anticarcinogênicos e antimicrobianos, em idiomas em Inglês e Português no período de 2019 a 2024. Resultados: A Physalis Angulata apresenta um perfil fitoquímico diversificado, com destaque para flavonoides, alcaloides, saponinas e esteroides, os quais conferem à planta um amplo potencial farmacológico, especialmente em relação às suas propriedades anti-inflamatória e antioxidante. Os mecanismos moleculares envolvidos nesses efeitos têm sido objeto de diversas investigações, evidenciando a relevância da espécie para o desenvolvimento de novos fármacos. Conclusões: A planta Physalis Angulata demonstra ser rica em flavonoides, alcaloides, saponinas e esteroides, compostos com comprovada atividade farmacológica, abrindo novas perspectivas para o desenvolvimento de fitoterápicos inovadores, com compostos bioativos para a indústria farmacêutica.
Tecnologias inovadoras para o tratamento da anemia falciforme: medicações versus transplante
Authors: Viana Helis Selma Rodrigues , Pimentel Daniele de Souza , Rodrigues Júnior Omero Martins
Published: October 2024

Introdução: A anemia falciforme faz parte de um grupo de denominado como Doença Falciforme (DF), que é o transtorno genético mais comum no mundo. Objetivo: Comparar a usualidade de tecnologias medicamentosas e de transplante no tratamento da anemia falciforme. Método: Os dados foram coletados aos pares, no período de fevereiro a março  de 2024, em consulta ao Portal da Biblioteca Virtual em Saúde e ao Portal de Periódicos Capes, nas bases de dados Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Eletronic Library Online (ScIELO) e Medical Literature Analysis and Retrieval System Online (MEDLINE). Resultados: No que se refere a terapia medicamentosa para o manejo da AF, pode-se citar que apesar de uma melhor compreensão da fisiopatologia da AF, os tratamentos medicamentosos disponíveis permanecem limitados. A hidroxiureia (HU) permaneceu como a única terapia aprovada pela FDA para a anemia falciforme durante décadas. A HU demonstrou aumentar os níveis de hemoglobina fetal (HbF) e modificar a gravidade da DF. Esta pode ser uma estratégia eficaz, desde que os níveis de gama globina estejam dentro de uma faixa que não apresente mais possibilidade de falcização devido à polimerização da globina mutante. Conclusões: Através do desenvolvimento desse estudo foi possível compreender a usualidade de tecnologias inovadoras de viés medicamentoso e de transplante na anemia falciforme, ficando evidenciado que a opção de tratamento está diretamenta associado ao caso clínico do paciente, bem como seu quadro geral de saúde.
Stress and Overwork in Remote and Isolated Communities: Causes, Impacts, and Solutions
Authors: N. Al-Hashim Mohammed
Published: October 2024

This paper explores the causes and impacts of stress and overwork in remote, isolated communities, where limited services, social isolation, and heavy workloads contribute to burnout and mental health issues. Potential solutions, including better healthcare access, social support, and work-life balance, are proposed to improve well-being in these regions.
Hydrodynamic 3D Simulation of Roche Lobe Overflow in High-mass X-Ray Binaries
Authors: Dickson David
Published: October 2024

While binary merger events have been an active area of study in both simulations and observational work, the formation channels by which a high-mass star extends from Roche lobe overflow (RLO) in a decaying orbit of a black-hole (BH) companion to a binary black-hole (BBH) system merits further investigation. Variable length-scales must be employed to accurately represent the dynamical fluid transfer and morphological development of the primary star as it conforms to a diminishing Roche lobe under the runaway influence of the proximal BH. We have simulated and evolved binary mass flow under these conditions to better identify the key transitional processes from RLO to BBHs. We demonstrate a new methodology to model RLO systems to unprecedented resolution simultaneously across the envelope, donor wind, tidal stream, and accretion disk regimes without reliance upon previously universal symmetry, mass flux, and angular momentum flux assumptions. We have applied this method to the semidetached high-mass X-ray binary M33 X-7 in order to provide a direct comparison to recent observations of an RLO candidate system at two overflow states of overfilling factors f = 1.01 and f = 1.1. We found extreme overflow (f = 1.1) to be entirely conservative in both mass and angular momentum transport, forming a conical L1 tidal stream of density and deflected angle comparable to existing predictions. This case lies within the unstable mass transfer (MT) regime as recently proposed of M33 X-7. The f = 1.01 case differed in stream geometry, accretion disk size, and efficiency, demonstrating nonconservative stable MT through a ballistic uniform-width stream. The nonconservative and stable nature of the f = 1.01 case MT also suggests that existing assumptions of semidetached binaries undergoing RLO may mischaracterize their role and distribution as progenitors of BBHs and common envelopes.
The BANANA Project. VII. High Eccentricity Predicts Spin–Orbit Misalignment in Binaries
Authors: Marcussen Marcus L. , Albrecht Simon H. , Winn Joshua N. , Su Yubo , Lundkvist Mia S. , Schlaufman Kevin C.
Published: October 2024

The degree of spin–orbit alignment in a population of binary stars can be determined from measurements of their orbital inclinations and rotational broadening of their spectral lines. Alignment in a face-on binary guarantees low rotational broadening, while alignment in an edge-on binary maximizes the rotational broadening. In contrast, if spin–orbit angles (ψ) are random, rotational broadening should not depend on orbital inclination. Using this technique, we investigated a sample of 2727 astrometric binaries from Gaia DR3 with F-type primaries and orbital periods between 50 and 1000 days (separations 0.3–2.7 au). We found that ψ is strongly associated with e, the orbital eccentricity. When e < 0.15, the mean spin–orbit angle is

〈
ψ
〉
=

6.9

−
4.1

+
5.4

degrees, while for e > 0.7, it rises to

〈
ψ
〉
=

46

−
24

+
26

degrees. These results suggest that some binaries are affected by processes during their formation or evolution that excite both orbital eccentricity and inclination.
Primordial Black Holes Generated by Fast-roll Mechanism in Noncanonical Natural Inflation
Authors: Heydari Soma , Karami Kayoomars
Published: October 2024

In this work, a new fast-roll (FR) mechanism to generate primordial black holes (PBHs) and gravitational waves (GWs) in generalized noncanonical natural inflation is introduced. In this model, choosing a suitable function for noncanonical mass scale parameter M(ϕ) gives rise to produce a cliff-like region in the field evolution path. When inflaton rolls down the steep cliff, its kinetic energy during an FR stage increases in comparison with a slow-roll stage. Hence, seeds of PBH production are born in this transient FR stage. Depending on the position of the cliff, appropriate cases of PBHs for explaining total dark matter, microlensing effects, LIGO–Virgo events, and NANOGrav 15 yr data can be formed. The density spectrum of GWs related to one case of the model lies in the NANOGrav 15 yr domain and behaves like

Ω

GW

0

∼

f

5
−
γ

. The spectral index γ = 3.42 for this case satisfies the NANOGrav 15 yr constraint. Moreover, regarding reheating considerations, it is demonstrated that PBHs are born in the radiation-dominated era. Furthermore, viability of the model in light of theoretical swampland criteria and observational constraints on cosmic microwave background scales are illustrated.
Atmospheric Retrievals Suggest the Presence of a Secondary Atmosphere and Possible Sulfur Species on L98-59 d from JWST Nirspec G395H Transmission Spectroscopy
Authors: Banerjee Agnibha , Barstow Joanna K. , Gressier Amélie , Espinoza Néstor , Sing David K. , Allen Natalie H. , Birkmann Stephan M. , Challener Ryan C. , Crouzet Nicolas , Haswell Carole A. , Lewis Nikole K. , Lewis Stephen R. , Yang Jingxuan
Published: October 2024

L 98-59 d is a Super-Earth planet orbiting an M-type star. We performed retrievals on the transmission spectrum of L 98-59 d obtained using NIRSpec G395H during a single transit, from JWST Cycle 1 GTO 1224. The wavelength range of this spectrum allows us to detect the presence of several atmospheric species. We found that the spectrum is consistent with a high mean molecular weight atmosphere. The atmospheric spectrum indicates the possible presence of the sulfur-bearing species H2S and SO2, which could hint at active volcanism on this planet if verified by future observations. We also tested for signs of stellar contamination in the spectrum and found signs of unocculted faculae on the star. The tentative signs of an atmosphere on L 98-59 d presented in this work from just one transit bodes well for possible molecular detections in the future, particularly as it is one of the best targets among small exoplanets for atmospheric characterization using JWST.
Prestorage hot water treatments retard papaya fruit deterioration and enhanced fruit quality in cold storage
Authors: Hanif Aliya , Azam Muhammad , Asif Muhammad , Hussain Imtiaz , Ali Safdar , Akram Muhammad Tahir , Yasmin Zarina , Awais Muhammad , Iqbal Muhammad Azhar , Naveed Khalid , Haider Sakeena Tul Ain
Published: October 2024

Papaya (Carica papaya) fruit has a short shelf life and suffers significant postharvest losses due to climacteric, instant ripening and perishable nature. Pre-storage hot water treatment (HWT) has significant potential to delay decay incidence in horticultural commodities. The present study was designed to evaluate effectiveness of HWT on ‘Red lady’ papaya fruit for minimizing the fruit decay and maintaining the quality during storage. Physiologically mature unripe ‘Red lady’ papaya fruit harvested from a commercial papaya orchard. Selected fruits were treated at three different hot water temperatures (50 °C, 52 °C and 54 °C) along with a control (room temp) for 10 minutes thereafter stored at 12 °C and 85–90% RH for four weeks. Different sensory evaluation, fruit quality scales and enzymatic activities were observed at weekly intervals. Fruit stored after 54 °C HWT showed lower weight loss (4.63%), decay incidence (5.1%) and higher fruit firmness (12.92 N) relative to control. Fruit treated at 52 °C HWT improved the fruit acidity, but total soluble solids decreased than control. The results revealed that ascorbic acid (33.33 mg/100 g), total phenolic contents (35 mg/g FW) total antioxidants (47.50% DPPH inhibition), and antioxidative enzyme activities were improved by 52 °C HWT. It is concluded that pre storage papaya fruit treatment (HWT @ 52 °C) preserves the quality of fruit throughout storage on the other hand at 54 °C HWT helps in decreased fruit decaying. It can be summarized that papaya fruit can be treated with hot water in the range of 52–54 °C to support the fruit shelf life and suppress fruit decay along with maintaining fruit quality.

Practical applications: Papaya (Carica papaya L.) is a climacteric fruit which is highly susceptible to fungal attacks after harvest. Due to its perishable nature, it becomes decayed and huge amount of highly nutritious and medicinally important fruit is wasted. Recently people are more concerned about food safety which limits the use of fungicides for controlling the fruit decay in papaya. However, heat treatment has tremendous potential to control microbial decay, and keep food commodities safe from hazardous chemicals. In this study, the hot water treatment has successfully suppressed the fruit decay and maintained fruit quality of papaya in the course of entire period of cold storage. These findings indicated that use of hot water treatment is a practical approach for increasing the shelf life of papaya fruit.
Partnering With Nurse Inventors and Entrepreneurs: A Guide for Nursing Professional Development Leaders
Authors: Brooks Beth A.
Published: October 2024

Health care innovation and entrepreneurship are key drivers of transformation in health care, re-shaping the way care is delivered, managed, and experienced. Innovation in health care spans a range of areas, including digital health, bio-technology, medical devices, tele-health, and health information systems. Entrepreneurs are leveraging technology to create solutions to improve patient outcomes, reduce costs, and address inefficiencies. Nurse inventors and entrepreneurs are blazing new trails that require nursing professional development leaders to consider new opportunities for collaboration. For nursing professional development leaders, fostering relationships with nurse entrepreneurs can unlock numerous benefits, from improving patient safety to enhancing nursing practice and facilitating advisory board appointments.

[
J Contin Educ Nurs.
2024;55(11):517–519.]
Multivariate polynomial regression by an explainable sigma-pi neural network
Authors: Guo Xiaoxiang , Shi Zuolin , Li Bin
Published: October 2024

Over the years, data-driven regression on univariate functions has been extensively studied. However, fast, effective, and stable algorithms for multivariate function fitting are still lacking. Recently, Kolmogorov-Arnold networks have garnered significant attention among scholars due to their superior accuracy and interpretability compared to multi-layer perceptrons. In this paper, we have demonstrated that the sigma-pi neural network, a form of Kolmogorov-Arnold networks, can efficiently fit multivariate polynomial functions, including fractional-order multivariate polynomials. Three examples were employed to illustrate the regression performance of the designed neural networks. The explainable sigma-pi neural network will lay the groundwork for further development of general tools for multivariate nonlinear function regression problems.
A class of constrained optimal control problems arising in an immunotherapy cancer remission process
Authors: Ouyang Yineng , Liang Zhaotao , Ma Zhihui , Wang Lei , Gong Zhaohua , Xie Jun , Gao Kuikui
Published: October 2024

By considering both the single drug dose and the total drug input during the treatment period, we propose a new optimal control problem by maximizing the immune cell levels and minimizing the tumor cell count, as well as the negative effects of the total drug quantity over time. To solve this problem, the control parameterization technique is employed to approximate the control function by a piecewise constant function, which gives rise to a sequence of mathematical programming problems. Then, we derive gradients of the cost function and/or the constraints in the resulting problems. On the basis of this gradient information, we develop a numerical approach to seek the optimal control strategy for a discrete drug administration. Finally, numerical simulations are conducted to assess the impact of the total drug input on the tumor treatment and to evaluate the rationality of the treatment strategy within the anti-cancer cycle. These results provide a theoretical framework that can guide clinical trials in immunotherapy.
Ought-Implies-Can in Context
Authors: Bradley Darren
Published: October 2024

If you ought to do something, does it follow that you are able to do it? The Kantian thesis that ought-implies-can seems intuitive and is widely accepted. Nevertheless, there are several powerful purported counterexamples. In this paper I will apply an independently motivated contextualism about ‘ought’ to make sense of the intuitions on both sides of the argument. Contextualism explains why ought-implies-can seems compelling despite being false in many contexts. The result will be that philosophers cannot in general appeal to ought-implies-can in their arguments.
D’un traitement épisodique à une imbrication semi-feuilletonnante puis feuilletonnante : Représenter le SIDA dans les séries américaines, des années 1980 à Pose (FX, 2018-2021)
Authors: Adouard Alexandre
Published: October 2024

Cet article entend explorer la manière dont la représentation du SIDA dans les séries américaines a évolué d’un traitement épisodique à une imbrication feuilletonnante à travers une étude de la série Pose (FX, 2018-2021). En contrepoint des premières représentations souvent stéréotypées qui refusent de faire du SIDA un thème central, la série de Ryan Murphy opte pour une visibilisation délibérée des plus vulnérables face à l’épidémie : les jeunes femmes trans africaines-américaines de la scène ballroom et les hommes gays noirs de leur entourage. Ainsi, l’éthique du format feuilletonnant, qui empêche « l’anonymat », permet de mettre en scène la résilience queer face à l’épidémie, dans une historiographie gay des années SIDA.
Une éthique de l’épisode en régime semi-feuilletonnant : de la subjectivation épisodique à l’individuation résistante dans Fringe et Dollhouse
Authors: Cabeza-Macuso Pablo
Published: October 2024

Cet article expose une lecture éthique du statut de l’épisode à partir de l’étude de cas des changements d’identités des personnages dans les séries semi-feuilletonnantes Fringe et Dollhouse. L’« éthique » est envisagée en un sens strictement spinoziste puisqu’il s’agit pour les personnages d’arriver jusqu’à la possession d’affects actifs en sortant du cadre épisodique qui leur est initialement imposé par un rapport de pouvoir. L’épisode y est tout d’abord envisagé comme un cadre normatif imposant des changements d’identité réguliers aux personnages (affects passifs). Cette domination d’un pouvoir sur les corps y est nommée « subjectivation épisodique ». Paradoxalement, la résistance des personnages désirant un mode de vie feuilletonnant émerge au cœur même de l’épisode. Cette opposition des personnages à une situation de domination prend le nom d’ « individuations résistantes » (passage aux affects actifs). L’article définit donc une éthique de l’épisode en régime semi-feuilletonnant : l’épisode est analysé comme l’espace d’où émergent de nouvelles subjectivités résistantes par l’entremise des mécanismes affectifs des personnages.
Star Trek : The Next Generation (1987-1994) ; un procès caché de l’humanité en sept saisons
Authors: Neau Jessy
Published: October 2024

Les questionnements éthiques sont au cœur de Star Trek : The Next Generation (1987-1994). Le vaisseau Enterprise explore la galaxie, guidé par les principes de la Directive Première, laquelle n’empêche pas l’équipage d’être confronté à des choix souvent difficiles. Chaque épisode permet de découvrir une nouvelle planète et, dès lors, de générer une réflexion anthropologique sur l’universalité de l’éthique. Les déséquilibres à l’ordre hiérarchique (enlèvements du capitaine, conflits entre membres de l’équipage) sont nécessaires, à la fois au rythme du récit et à une réflexion de nature sociale : ces déséquilibres étant partiellement rétablis mais oubliés l’épisode suivant, leur règlement temporaire permet de poursuivre indéfiniment la mission. A priori, la valeur cumulative de toutes ces expériences est donc assez peu mise en avant. Et pourtant, un deus ex machina fait bien de cette expédition spatiale une adjonction d’épreuves à valeur éthique, surgissant dans le pilote et revenant dans l’épisode final : celui du procès des humains intenté par « Q », Némésis du capitaine Picard. Créature omnipotente, Q peut apparaître comme l’orchestrateur et l’arbitre de toutes les situations auxquelles l’équipage fait face : lors du pilote, il a prévenu que les humains seront jugés selon le comportement qu’ils auront montré au cours de cette mission. Juge et procureur du point de vue éthique, Q ne serait-il pas aussi « grand imagier » du point de vue narratif ? C’est donc cette dimension dissimulée, différée et oubliée du procès des humains autant que de l’archinarrateur dans Star Trek : TNG qu’il convient d’interroger.
The Good Place, ou ce que les séries se doivent les unes aux autres
Authors: Favard Florent
Published: October 2024

Cet article propose d’analyser la série The Good Place (NBC, 2016-2020) sous l’angle de la réflexivité et du métadiscours qu’elle déploierait sur la sérialité contemporaine en la comparant à d’autres séries riches en métatexte qui explorent des thèmes similaires. Comme Westworld (HBO, 2016-2022), The Good Place décrit un simulacre infernal basé sur une succession de reboots qui ne produisent d’abord aucun sens, du fait de l’amnésie de leurs protagonistes. La série partage aussi avec Person of Interest (CBS, 2011-2016) un discours similaire sur la valeur de la vie humaine face à des algorithmes et des systèmes de surveillance de plus en plus inhumains et déshumanisants, à mettre en regard de la diffusion internationale de The Good Place, qui prend place sur la plateforme Netflix. Enfin, les liens prégnants qui existent entre The Good Place et Lost (ABC, 2004-2010) permettent d’explorer le discours que tient la première sur la « promesse de dénouement » et la « bonne » fin des séries.
Computer-Assisted Analysis of Histopathological Images
Authors: Saxena Pranshu , Singh Sanjay Kumar , Srivastav Gaurav , Mamoon Rashid
Published: October 2024

Histopathological image analysis is a specialised area of medical imaging that involves the careful examination and interpretation of tissue samples to diagnose and investigate diseases. We begin by reviewing the traditional methods of histopathological image analysis and their limitations, setting the stage for the necessity of computational approaches. The study then delves into the core components of computer-assisted analysis, including preprocessing techniques, feature extraction, and classification algorithms. Preprocessing steps such as staining normalization, noise reduction, and image segmentation are critical for preparing raw images for further analysis. Feature extraction methods, ranging from handcrafted features to DL based features, are discussed in detail, emphasizing their role in capturing relevant tissue characteristics. The classification stage employs various machine learning models, including SVM, RF, and NN, with a focus on CNN due to their superior performance in image recognition tasks.
Computer-Assisted Analysis of Myelography
Authors: Kulshrestha Rhythm
Published: October 2024

Myelography, dating back to the 1920s, injects contrast into the spinal canal to diagnose spinal conditions. Evolving with technology, it now utilizes CT and safer contrast agents. Still valuable, it aids in detecting CSF leaks, cervical root avulsion, and cases where MRI is impractical, providing dynamic imaging for precise diagnosis in specific clinical situations. Computer-assisted analysis plays a significant role in the field of myelography, where advanced technologies like machine learning, computer vision, and artificial intelligence (AI) are increasingly being integrated for enhanced image interpretation and diagnosis. These technologies offer the potential to revolutionize the way myelography is performed and analyzed, leading to improved patient care, disease detection and medical advancements.
Integrative Imaging and Molecular Profiling
Authors: Gupta Tanaya , Aggarwal Sahil Kumar , Mathur Tanya
Published: October 2024

Recent advancements in digital medical imagery have ushered in a new era of diagnostic and therapeutic capabilities by integrating breakthroughs in DNA, RNA, genomics, and omics technologies. These innovations have transformed healthcare practices, offering unprecedented opportunities for detailed molecular profiling and analysis. By combining genomic data with high-resolution imaging modalities such as MRI, CT scans, and PET scans, medical professionals can achieve a comprehensive understanding of both anatomical structures and underlying physiological processes at a molecular level. This synergistic approach enables clinicians to uncover genetic predispositions, elucidate disease mechanisms, and formulate personalized treatment strategies with enhanced precision. By correlating genomic insights directly with imaging findings, healthcare providers can tailor interventions more precisely, monitor treatment responses effectively, and forecast disease trajectories with greater accuracy.
Design Principles for Chronic Disease Self-Management Systems
Authors: Dadgar Kourosh , Joshi K. D.
Published: October 2024

The use and design of digital technologies for the self-management of chronic diseases are increasing. Self-management systems designed without theoretically driven design principles are ineffective and inconsistent. This chapter proposes design principles based on the characteristics of the digital technologies: (1) re-programmability, (2) homogenization of data, and (3) self-referential nature. The design principles are instantiated in a diabetes mobile app and illustrated in use case diagrams. The proposed principles increase the projectability of system design principles and simplify the complexity of the problem space for ICT-enabled self-management systems.
Digital Health Technologies for Preventive Cardiology
Authors: Mala Shaveta , Deep Upasna , Mala Ekta , Akhai Shalom
Published: October 2024

This chapter explores the potential of digital health technologies in preventive cardiology, including telemedicine, wearables, sensors, artificial intelligence, and mobile health platforms. These technologies have shown effectiveness in reducing cardiovascular risk factors and improving patient outcomes. However, barriers to widespread adoption include digital literacy gaps, limited internet access, data privacy concerns, and technical complexities. To overcome these, this chapter proposes strategies like national e-Health guidelines, stakeholder engagement, improved regulatory standards, human-centered design principles, integration with existing healthcare systems, technology infrastructure investments, and fair pricing models. Addressing data security, accessibility, and ethical considerations is crucial for a future of personalized, proactive, and accessible cardiovascular care. The chapter concludes by highlighting the challenges of digital health technologies in preventive cardiology.