bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA methylation Analysis and Bioinformatics causative genes prediction in idiopathic clubfoot
Authors: Shi Ningning , Wang Lexiang , Wang Xu , Li Junyi , Zhang Yong
Published: July 2023

Background
Idiopathic clubfoot is a common congenital deformity that affects approximately1-3‰ of all newborns. DNA methylation is associated with congenital malformations. However, no study has been reported on the DNA methylation in idiopathic clubfoot.
Methods
In order to determine the methylation differences in idiopathic clubfoot, we have used newborn blood tissue from three children with clubfoot and normal controls. DNA was extracted from peripheral blood samples, the methylation analysis was performed using Reduced Representation Bisulfite Sequencing.We also perform gene prediction for idiopathic clubfoot by bioinformatics.
Results
RRBS revealed 474 differentially methylated genes (Absolute methylation differences = 10%, Q-value < 0.001) in newborns between clubfoot and unrelated normal. We also obtained 68 genes using the deep learning + network representation method. And then take the intersection of the 474 differentially methylated genes, we get three genes which may cause the clubfoot including GLI2,TRIP13 AND ANKRD2.
Conclusion
For the first time, these results provide epigenetic machanism on idiopathic clubfoot by DNA methylation analysis and bioinformatics. GLI2,TRIP13 AND ANKRD2 may contribute to the occurrence of idiopathic clubfoot.
Assessment of the Ground Coverage Ratio of AgriVoltaic systems as a proxy for potential crop productivity
Authors: Dupraz Christian
Published: July 2023

The yield of crops in both agrivoltaic (AV) and agroforestry (AF) systems is difficult to predict. The shade pattern of an AV system is not usual and quite different from the one of AF systems. Most countries allow AV systems on croplands only if the crop productivity is maintained (e.g. in France) or slightly reduced, as in Japan and Germany, with 80% and 66% minimum relative yield (RY) required respectively. We suggest to use the Ground Coverage Ratio (GCR: ratio of the area of photovoltaic panels to the area of land) as an indicator of the crop potential productivity in AV systems. The GCR can be easily computed and controlled for all kinds of AV systems with fixed (horizontal, tilted or vertical) or mobile (on 1 or 2 axis trackers) panels. We provide here a synthesis of published data for crop productivity under AV systems. We included only publications that provided both the GCR of the system and the crop RYs, which requires a reliable non AV control plot. Several publications were excluded as a consequence of doubts about the validity of the measurements (too small sized systems with strong edge effects, unreliable control plots). Despite the scattering of results, a clear pattern is evidenced: RYs decrease rapidly with increasing GCRs. It appears that a GCR < 25% is required to ensure that most crop RYs stay > 80%. Our results are consistent with a recent meta-analysis on the impact of shade on crops. Using the GCR criterion to validate AV projects is a simple and costless alternative to the tricky control of crop yields in the fields.
Exploring the Optimal Intertwin Delivery Interval for Vaginal Delivery
Authors: Justman Naphtali , Goldfriend Roee , Rosh Bar , Wolfovitch Amir , Siegler Yoav , Tzur Lilia , Bachar Gal , Buchnik Gili , Zipori Yaniv , Khatib Nizar , Weiner Zeev , Vitner Dana
Published: July 2023

Objective
The effect of prolonged intertwin delivery interval (IDI) is not well studied. This work aimed to assess the inflection point for Cesarean delivery (CD) and associated adverse maternal and neonatal outcomes.
Methods
This was a retrospective cohort study at a single tertiary care center. The study included women with twin pregnancies in 2010–2019 who reached the second stage of labor, and assessed the most predictive cutoff for CD using Youden J statistic and compared adverse maternal and neonatal outcomes between short and prolonged intertwin delivery intervals.
Results
A total of 461 gravidas reached the second stage of labor and were included in the study. Using the ROC curve and Youden J statistic, the IDI cutoff was set at 15 min (80% sensitivity, 75% specificity, p < 0.001), with 312 women in the short and 149 in the prolonged IDI groups. Women in the prolonged IDI group were less likely to deliver the second twin vaginally (75.8% vs. 93.3%, p < 0.001). Postpartum hemorrhage (PPH) (39.1% vs. 24.7%, p = 0.01), and placental abruption (4% vs. 1%, p = 0.03) were more likely to occur in the prolonged IDI group. An increased rate of neonatal acidemia and low 5-minute Apgar score were also found in the prolonged IDI group (15.7% vs. 4.3%, P = 0.01, 9.7% vs. 3.5%, p = 0.008; respectively).
Conclusion
IDIs of more than 15 min are associated with increased risk of adverse maternal and neonatal outcomes. These findings should be used for counseling and managing twin pregnancies attempting vaginal delivery.
Novel Iboga-derivatives Modulate Nociception and Inflammation in Acute Mouse Pain Model
Authors: Bhattacharya Tuhin , Gupta Abhishek , Gupta Shalini , Saha Samrat , Ghosh Shatabdi , Shireen Zofa , Sinha Surajit , Dey Sanjit
Published: July 2023

The present study explored efficient and exclusive analgesic effects of iboga-analogs in formalin-induced mouse via acute pain model. Novel iboga derivatives namely iboga-alcohol, iboga-amide, iboga-methylamide and iboga ester-exo were administered intraperitoneally to evaluate the anti-nociceptive, anti-inflammatory and neuromodulatory effects. Pain assessment was done by paw diameter, paw licking and tail immersion tests. Locomotor activity and anxiety-like behavior were determined by open field test and elevated plus maze. Inflammatory mediators, neurotransmitters and neurotrophic factors were measured from isolated serum, paw tissue and spinal segment. Iboga-analogs significantly reduced paw diameters. Decreased tail flick latency reversed in iboga-alcohol and methyl-amide particularly. Restricted locomotion was also significantly reversed in iboga-alcohol, iboga-amide, and iboga-methyl amide. Anxiolytic behaviour was obtained in the iboga-alcohol, iboga-amide and methyl-amide treated groups. Paw Substance P, CGRP, COX-2 and p65 nuclear translocation; serum IL-6 & TNF-α levels were significantly decreased in the iboga-alcohol treated group. Iboga-alcohol reversed the downregulation of GABA, Dopamine, and elevation of Substance P, NK1R and Glutamate. HRMS analysis confirmed the passage of all iboga-analogs in the brain. Iboga-analogs overturned the depleted BDNF whereas, GDNF elevation was further exaggerated. Taken together, these novel iboga-analogs, particularly iboga-alcohol, executed effective anti-nociception and prevented neuroinflammation. They warrant further clinical applications in acute pain situations.
Clinical and therapeutic outcomes of pediatric pituitary adenomas: A single pituitary center experience
Authors: Kilci Fatih , Jones Jeremy Huw , Çaklılı Melih , Ceylan Savaş , Çizmecioğlu-Jones Filiz Mine
Published: July 2023

Purpose Pediatric pituitary adenomas (PPA) are rare. Although PPAs are mostly benign, they can be challenging to manage. Most studies evaluating PPA are based on surgical series. We aimed to present the clinical features, hormonal status and treatment outcomes of children with PPA managed in a joint neuroendocrine setting. Methods In this single-center study, demographic, clinical and endocrinological data of patients under 19 years old who were followed up with the diagnosis of PPA between 2002–2022 were retrospectively reviewed. A total of 21 studies published in the past 20 years were also systematically reviewed. Results There were 79 patients (52 girls, 27 boys) with a median age of 15.8 years. Median follow-up time was 30 months. The most common adenoma subtype was non-functioning adenoma (NFA) (35.5%), followed by prolactinoma (29.1%), corticotropinoma (21.5%), and somatotropinoma (13.9%), respectively. The frequency of micro and macroadenomas was almost equal while 38% of all adenomas were invasive. Headache, visual impairment and menstrual irregularity were the most common complaints, while the most common hormonal deficiency at diagnosis was central hypothyroidism (31.6%), followed by hypogonadotropic hypogonadism (22.7%), growth hormone deficiency (15.2%) and central adrenal insufficiency (11.4%), respectively. Fifty patients (63.2%) underwent endoscopic endonasal transsphenoidal surgery (EETS). Following the surgery, impaired endocrine functions recovered at a rate of 62% while permanent central diabetes insipidus was observed in 6%, and new onset hypopituitarism developed in 4%. Conclusion NFA was more common in this cohort than in previous reports, which is one of the largest PPA series in the literature. Hormonal disorders, which were common at the time of diagnosis, were largely resolved with appropriate endocrinological and surgical approaches, while the rate of pituitary hormonal deficiencies after EETS was relatively low. Therefore, we recommend that children with PPA be managed in the setting of a high-volume pituitary centers to provide long-term low morbidity.
Using domain adaptation and inductive transfer learning to improve patient outcome prediction in the intensive care unit
Authors: Mutnuri Maruthi Kumar , Stelfox Henry T. , Forkert Nils D. , Lee Joon
Published: July 2023

Predicting patient outcomes in the intensive care unit (ICU) can allow for more effective and efficient patient care. Deep learning models are effective in learning from data to accurately predict patient outcomes; however, they require huge amounts of data to train and massive computational power. Transfer learning (TL) helps in scenarios when data and computational resources are scarce. TL is commonly used in medical image analysis and natural language processing but is comparatively rare in electronic health record (EHR) analysis. In medical image analysis and natural language processing, domain adaptation (DA) is the most commonly used TL method in the literature while inductive transfer learning (ITL) is quite rare. This study explores DA as well as rarely researched ITL for predicting ICU outcomes using EHR data. To investigate the effectiveness of these TL models, we compared them with baseline models of fully connected neural networks (FCNN), logistic regression, and lasso regression in the prediction of 30-day mortality, acute kidney injury (AKI), hospital length of stay (H_LOS), and ICU length of stay (ICU_LOS). TL models transfer the knowledge gained while training for the source prediction task on the source domain to improve the prediction performance of the target prediction task on the target domain. Whereas baseline models were trained directly on the target domain for the target prediction task. Two cohorts were used in this study for the development and evaluation. The first was eCritical, a multicenter ICU data linked with administrative data with 55,689 unique admission records from 48,672 unique patients admitted to 15 medical-surgical ICUs in Alberta, Canada, between March 2013 and December 2019. The second was MIMIC-III, a single-center, publicly available ICU dataset from Boston, USA, acquired between 2001 and 2012. Random subsets of training data, ranging from 1% to 75%, as well as the full dataset were used to compare the performances of DA and ITL with FCNN, logistic and lasso regression. Overall, the ITL outperformed baseline FCNN, logistic and lasso regressions in 55 out of the 56 comparisons (7 data subsets, 4 outcomes, and 2 baseline models), whereas DA models outperformed the baseline models in 45 out of 56 cases. ITL performance was comparatively better than DA, considering the number of times it outperformed baseline models and the margin with which it outperformed baseline models. In 11 out of 16 cases (8 out of 8 for ITL and 3 out of 8 for DA), TL models outperformed baseline models when trained using the 1% data subset. This is significant because TL models are useful in data-scarce scenarios. The publicly available pre-trained models from this study can be used to predict ICU patient outcomes and serve as building blocks in further research for the development and validation of models in other cohorts and outcomes.
Adherence to multidisciplinary team meeting recommendations in elderly patients with HER2-positive breast cancer
Authors: Geissler Franziska , Maggi Nadia , Brülhart Alice , Nesic Ksenija , Zwimpfer Tibor A. , Schoetzau Andreas , Vetter Marcus , Kappos Elisabeth A. , Weber Walter P. , Kurzeder Christian , Heinzelmann-Schwarz Viola , Dedes Konstantin J. , Schwab Fabienne Dominique
Published: July 2023

Purpose
Applying current treatment guidelines to elderly breast cancer (BC) patients is challenged by limited trial guidance, higher toxicities, and non-cancer related mortality. This study investigated adherence to multidisciplinary team meeting (MDTM) recommendations in elderly women with HER2 positive BC (HER2+BC) and its impacts on patient survival.
Methods
This retrospective multicentre cohort study collected data from 305 patients with primary diagnosis of HER2+BC. Women aged ≥65 years were classified into “concordant” or “discordant” groups according to MDTM recommendation adherence. Cox proportional hazards models and logistic regression analysis were used to assess the association between prognostic factors and patient outcomes.
Results
Of 305 HER2+BC patients, 111 (36%) were ≥65 years old. Of these, 55 (49.5%) and 53 (47.7%) were assigned to the concordant or discordant groups, respectively. The most frequent cause of MDTM discordance was treatment rejection by patients (57%). Median age (79 vs 70 years, p = <0.001) and Charlson Comorbidity Index (score 6 vs 5, p = 0.017) were significantly higher in the discordant group. After adjusting for age, UICC stage and hormone receptor status, overall survival (OS; HR 1.49, CI [0.64-3.46], p = 0.36) showed no significant difference between groups with a median follow up of 42.8 months. Patients with pre-existing cardiac diseases (29.6%) had significantly reduced OS (log-rank test p = 0.0082).
Conclusion
Adjustments to MDTMs for older BC patients may be necessary to increase patient treatment acceptance. Moreover, approaches to reduce treatment intensity in selected elderly patients with HER2+BC should be investigated further.
WITHDRAWN: Geochemical and isotopic characteristics of thermal and mineral waters in the Sakarya (Adapazarı) Pull-Apart Basin
Authors: Akıllı Hafize , Kayadibi Önder , Gürboğa Şule , Mutlu Halim , Karadağlar Macit , Arıkan Serap , Tan Sevilay
Published: July 2023

This study based on the project titled "Examination of the Economic Potentials of the developed Basins Along the North Anatolian Fault System (NAFS) and East Anatolian Fault System (EAFS) with Remote Sensing and Geographic Information Systems (GIS) Methods" carried out by the General Directorate of Mineral Research and Exploration (MTA). The Sakarya (Adapazarı) Basin is controlled by the right lateral strike-slip North Anatolian Fault Zone (NAFS) which is one of the most active structures in Turkey. The Basin showing a different evolution mechanism from the pull-apart basins along the NAFS is represented by the sedimentation by the Sakarya River in the northern site towards the Black Sea. Moreover, the southern margin of the basin is shaped by the active faults. On the accounts of these factors, the geological significance of the basin for both geothermal and deformation features entirely focuses around the southern margin of the basin. In the study area, the Paleocene and Eocene aged limestones have abundantly broken, cracked and karstic cavity. The clayey-silty levels of the Plio-Quaternary sediments on the limestones showing the reservoir character are also cover rock.Chemical and isotopic compositions were determined by sampling from hot fluids produced from wells drilled in the Sakarya Basin and various cold-water sources. The electrical conductivity of cold and thermal waters varies between 199 and 7250 µS/cm. Temperatures of fluids taken from wells and springs are between 24 and 80° C. According to the classification of International Association of Hydrogeologists (IAH), Sakarya thermal waters are classified as boron-containing sodium, chlorinated, bicarbonate thermal and mineral waters and are deeply circulating fluids.The maturation index of Sapanca-Uzunkum and Akyazı waters is greater than 2. The cation geothermometers have been applied to these waters as well as silica geothermometers. The reservoir temperatures of these waters calculated by silica and cation geothermometers are 44-109oC and 34-99oC, respectively. These results can be attributed to the enrichment of oxygen isotopes in Akyazı and Sapanca-Uzunkum waters, their deep circulation and longer interaction with reservoir rocks.
A computational validation for the Health Concept Maturity Levels Questionnaire
Authors: Trognon Arthur , Habibi Islem , Altakroury Hamza , Mahdar-Recorbet Loann , Poli Alizée , Servais David , Lambert Julien , Béjean Mathias , Abraham Denis
Published: July 2023

Background
The healthcare market is undergoing rapid transformation, requiring the integration of user needs from the earliest stages of product and service design. Living Labs are emerging as a model for the co-creation and evaluation of user-centered innovations. In this work, we developed a health CML grid and questionnaire to assess the maturity of health concepts.
Methods
The research process included multiple stages, starting with the creation of the Association Innov'Autonomie - Health Concept Maturity Levels Questionnaire − 178-items (AIA/CMLHQ178), designed to evaluate health concept maturity levels. Speech acts from Health CML expert interventions were then annotated and used as data for our machine learning and deep learning models. We used the CatBoost algorithm in the first experiment to discern individual Health CML factors from speech acts to generate factor probabilities used to feed a neural network trained to take the final decision, to evaluate whether the network could accurately identify the membership factors of Health CML criteria when presented with items from the AIA/CMLHQ178 questionnaire.
Results
The results of the study indicate that only the models trained with the true factors are able to correctly identify the corresponding factor in the sequentially encoded texts, with the exception of the need domains whose artificial performance was measured according to sensitivity. The general performance of the different CatBoost algorithms used to predict one factor versus the other two showed similar performance. For the questionnaire, the models trained with the real factors also showed better performance in identifying the matching factors compared to the random factors. A marginal difference was observed between the "Need" and "Technology" factors.
Conclusion
This study provides initial evidence of content validity for the AIA/CMLHQ178, introducing a novel approach to validate psychometric instruments using machine learning and deep learning techniques. However, overlaps between "Programmatic" and "Need" factors indicate a need for improvement in the CML Health model. Future work will focus on enhancing these models and investigating their potential application in other psychometric tools.
Opinions and perceptions of patients with cardiovascular disease on adherence: a qualitative study of focus groups
Authors: Carbonell-Soliva Álvaro , Nouni-García Rauf , López-Pineda Adriana , Cordero-Fort Alberto , Pérez-Jover Virtudes , Quesada Jose A. , Orozco-Beltrán Domingo , Nolasco Andreu , Castellano-Vázquez Jose Maria , Mira-Solves Jose Joaquin , Gil-Guillén Vicente F. , Carratalá-Munuera Concepción
Published: July 2023

Background: Cardiovascular diseases are becoming more frequent throughout the world. Adherence to both pharmacological and non-pharmacological treatment, as well as lifestyles, is important for good management and control of the disease. This study aims to explore the opinions and perceptions of patients with ischemic heart disease on the difficulties associated with therapeutic adherence.
Methods. An interpretive phenomenological study was carried out using focus groups and one semi-structured interview. The MAXQDA qualitative data analysis program was used for inductive interpretation of the group discourses and interview. Data were coded, and these were grouped by categories and then consolidated under the main themes identified.
Results. Two in-person focus groups and one remote semi-structured interview were performed. Twelve participants (6 men and 6 women) from the Hospital de San Juan de Alicante participated. The main themes identified were aspects related to the individual, heart disease, drug treatment, and the perception of the health care system.
Conclusions. Adhering to recommendations on healthy behaviors and taking prescribed medications for cardiovascular disease was important for most participants. However, they sometimes found polypharmacy difficult to manage, especially when they did not perceive the symptoms of their disease. Participants related the concept of fear to therapeutic adherence, believing that the latter increased with the former. The relationship with health professionals was described as optimal, but, nevertheless, the coordination of the health care system was seen as limited.
Altered Brain Functional Connectivity of resting-state networks in Neurologically Asymptomatic Patients with End-Stage Renal Disease Undergoing Maintenance Hemodialysis
Authors: Wu Yunfan , Liu Mengchen , Lin Weizhao , Zhou Zhihua , Meng Shandong , Ma Xiaofen , Fu Shishun , Su Huanhuan , Li Jincheng , Liang Quanhai , Li Meng , Xu Shoujun , Xiao Wenqing , Chen Yanying , Li Rujin , Xia Bin , Jiang Guihua
Published: July 2023

Purpose: To investigate changes in the functional connectivity (FC) of neurologically asymptomatic patients with end-stage renal disease (ESRD) on haemodialysis (HD) and determine the relationship between these changes and clinical variables.
Methods:Resting-state functional magnetic resonance imaging was performed in 36 neurologically asymptomatic patients with ESRD on HD (ESHD) and 31 healthy control subjects. Using independent component analysis, abnormal resting-state networks and FC regions were identified in the two groups. Partial correlation analysis was performed between abnormal FC regions and clinical variables.
Results: The ESHD group exhibited abnormal FC in multiple regions of three RSNs, including the posterior default mode network (DMN), attention network, and external visual network (VN). Significant correlations were found between the FC values of multiple brain regions (the right supramarginal gyrus, the left angular gyrus, and the left middle occipital gyrus) of the DMN or VN and the neurocognitive scale scores in the ESHD group. Additionally, the FC value of the right median cingulate gyrus was negatively correlated with the serum calcium level.
Conclusion: Our study found that the ESHD group exhibited multiple abnormal FC regions in three RSNs involved in visual–spatial processing, short-term memory, language, attention and executive function; these findings are consistent with the characteristics of cognitive impairment during the HD process. Our findings provided both empirical and complementary evidence indicating that FC changes may be associated with the underlying clinical symptoms of patients with ESHD.
Rare variants in 45 genes account for 25% of cases with NDDs in 415 pediatric patients
Authors: Aspromonte Maria Cristina , Conte Alessio Del , Polli Roberta , Baldo Demetrio , Benedicenti Francesco , Bettella Elisa , Bigoni Stefania , Boni Stefania , Ciaccio Claudia , D’Arrigo Stefano , Donati Ilaria , Granocchio Elisa , Mammi Isabella , Milani Donatella , Negrin Susanna , Nosadini Margherita , Soli Fiorenza , Stanzial Franco , Turolla Licia , Tosatto Silvio C.E. , Murgia Alessandra , Leonardi Emanuela
Published: July 2023

Neurodevelopmental disorders (NDDs) are common conditions including clinically diverse and genetically heterogeneous diseases, such as intellectual disability, autism spectrum disorders, and epilepsy. Understanding the genetic causes of NDDs is challenging due to their complex and heterogeneous nature. In this study, a targeted gene panel sequencing has been used to investigate the genetic causes of NDDs in a cohort of 415 pediatric patients. We identified 60 pathogenic and 49 potentially pathogenic variants in 102 individuals that accounted for 25% of NDD cases in the cohort. The majority of causative variants were de novo, with some inherited from mildly affected parents. Loss-of-function variants were the most common type of causative mutation. In silico analysis tools were used to assess the potential impact of variants on splicing and structural/functional effects of missense variants. The study highlights the challenges in variant interpretation and predicting associated phenotypes. The clinical features observed in some patients were atypical for the mutations found in their genes. Overall, this study provides valuable insights into the genetic causes of NDDs and emphasizes the importance of understanding the underlying genetic factors for accurate diagnosis, prognosis, and intervention development in neurodevelopmental conditions.
The Impact of Operating Efficiency, Non-Interest Income, and Bank Size on Profitability: Evidence from the Ethiopian Banking Sector
Authors: Hordofa Dereje Fedasa
Published: July 2023

This manuscript examines the effect of operating efficiency and non-interest income on bank profitability in the Ethiopian banking sector. Drawing on a comprehensive literature review and utilizing panel data from 15 banks over a specified period, we investigate the determinants of profitability and their implications for the Ethiopian banking landscape. The findings reveal that operating efficiency, measured through various indicators, positively influences bank profitability, aligning with prior research. Furthermore, the analysis highlights the complex relationship between non-interest income and profitability, indicating a significant but non-linear association. The study also underscores the role of bank size and leverage as important factors shaping profitability in the Ethiopian context. The results contribute to the existing literature by providing empirical evidence on the specific dynamics of the Ethiopian banking sector and offer valuable insights for policymakers and industry practitioners. By understanding the factors that drive bank profitability, stakeholders can formulate effective strategies to promote a sustainable and robust banking sector in Ethiopia. This manuscript provides a valuable contribution to the literature and offers actionable recommendations for enhancing the performance and profitability of banks in Ethiopia.
NER Sequence Embedding of Unified Medical Corpora to incorporate Semantic Intelligence in Big Data Healthcare Diagnostics
Authors: Shafqat Sarah , Anwar Zahid , Javaid Qaisar , Ahmad Hafiz Farooq
Published: July 2023

Clinical diagnoses is a challenging task for which high expertise is required at doctors’ end. It is recognized that technology integration with clinical domain would facilitate the diagnostic process. Semantic understanding of medical domain and clinical context is needed to make intelligent analytics. These analytics need to learn the medical context for different purposes of diagnosing and treating patients. Traditional diagnoses are made through phenotype features from patients’ profile. It is also a known fact that diabetes mellitus (DM) is widely affecting the population and is a chronic disease that requires timely diagnosis. Motivation for this research comes from the gap found in discovering the common ground for medical context learning in analytics to diagnose DM and its comorbidity diseases. Therefore, a unified medical knowledge base is found significantly important to learn contextual Named Entity Recognition (NER) embedding for semantic intelligence. Our search for possible solutions for medical context learning told us that unified corpora tagged with medical terms was missing to train the analytics for diagnoses of DM and its comorbidities. Hence, we put effort in collecting endocrine diagnostic electronic health records (EHR) corpora for clinical purposes that is labeled with ICD-10-CM international coding scheme. International Codes for Diseases (ICD) by World Health Organization (WHO) is a known schema to represent medical codes for diagnoses. The complete endocrine EHR corpuses make DM-Comorbid-EHR-ICD-10 Corpora. DM-Comorbid-EHR-ICD-10 Corpora is tagged for understanding the medical context with uniformity. We experimented with different NER sequence embedding approaches using advanced ML integrated with NLP techniques. Different experiments used common frameworks like; Spacy, Flair, and TensorFlow, Keras. In our experiments albeit label sets in form of (instance, label) pair for diagnoses were tagged with Sequential() model found in TensorFlow.Keras using Bi-LSTM and dense layers. The maximum accuracy achieved was 0.9 for Corpus14407\_DM\_pts\_33185 with maximum number of diagnostic features taken as input. The sequential DNN NER model diagnostic accuracy increased as the size of corpus grew from 100 to 14407 DM patients suffering from comorbidity diseases. The significance of clinical notes and practitioner comments available as free text is clearly seen in the diagnostic accuracy.
Development of a method for constructing a 3D image of the surface structure of parts based on their profilograms
Authors: Abramov A. D. , Nosov N. V. , Ladyagin R. V.
Published: July 2023

This work is aimed at obtaining 3D images of the microrelief of working surfaces of machine parts using a profilograph, which represents a simple and convenient approach to analyzing the surface structure. To obtain information about the 3D distribution of height parameters of a microrelief, its structural parameters, rather than microgeometry profile, should be used. To build a 3D model of the microrelief of precision parts, a profilogram obtained by conventional GOST methods is used. The digital values of a signal are entered into a computer in the form of a one-dimensionalarray (the number of elements of this array will determine the size of the generated image). In the process of modeling, new requirements for the microgeometry characteristics of working surfaces are formulated. It is proposed to consider the one-dimensional array as a single random realization of a video camera signal along the X axis. Then its replication along the Y axis will form a 3D model of the examined surface. In order to eliminate the drawback of inadequate imaging of the 3D model of the studied surface, it is proposed to introduce a random component using a pseudorandom number generator to add noise to each successive line of the image under construction. This generator is implemented in the C++ programming language. It was established that video signal graphs for different lines differ significantly, thereby reflecting the real microrelief structure. The proposed method for constructing digital images can be used to obtain a 3 D model of the surface structure under examination for further processing of these signals by an optical electronic method, without using complex and expensive equipment.
Mechanically deboned poultry meat and its role in rational and efficient use of raw materials
Authors: Gushchin V. V.
Published: July 2023

The growth in poultry meat production is a worldwide trend. Industrial poultry meat processing is also developing with production of a wide range of products. The technology of mechanical deboning of poultry meat and carcass parts is widely used in complex non-waste production. Mechanically deboned poultry meat (MDPM) is believed to be of inferior quality and its use is restricted by certain rules in different countries of the world. At the same time, hand separated meat is accepted as conventional meat and is not subjected to any restrictions. Over the last decades, the technology and equipment have been created that allow approximating MDPM to the category “meat” in terms of quality characteristics and reducing risks in its use upon reduction of pressure in the process of its production. However, costs of new equipment that enables producing a product with higher quality do not provide the expected efficiency, and a positive effect will be achieved only in the case of clear legal solutions regarding separation of MDPM types and methods of their classification and identification. The volume of scientific publications concerning a solution to this problematic theme is significant and scientists from many countries search for approaches to its realization differently. The difficulty in finding a solution is caused by the multifaceted nature of the problem, the character of non-standardized raw materials, a type of equipment being used to obtain different MDPM types, and various methods of investigations. Nevertheless, the performed studies create conditions for improvement of the approach to classification of different MDPM types by the production method and maximum allowable threshold values of the main standardized parameters, assessment methods, detection of their characteristics and substantiation of terminology.
Korelasi Disiplin Sholat Lima Waktu dengan Kedisiplinan Mahasiswa Program Studi Kedokteran Program Sarjana Universitas Lambung Mangkurat
Authors: Aulia Rahmah Rifka , Clarizza Dhea Nafadhika Andi , Yasmin Raodhatul Isra Putri , Muhammad Irhamna Husin Gt
Published: July 2023

This article aims to describe the correlation between prayer time discipline and the discipline of students in the Medical Study Program at Lambung Mangkurat University in 2022. The research method used is quantitative correlational analysis. In analyzing the correlation between the independent variable of five-time prayer discipline and the dependent variable of student discipline in the Medical Study Program at ULM in 2022, the researcher used partial correlation analysis and obtained a result of 0.13, indicating a strong relationship between the two variables. Based on the normality test using the Kolmogorov-Smirnov test, if the value is above 0.05, the data distribution is considered to meet normality. Therefore, it can be stated that H0 is rejected because H0: ρy1 = 0, and H1 is accepted because H1: ρy1 > 0. This means that there is a significant correlation between the discipline of performing the five-time prayer and the discipline of students in the Medical Study Program at ULM in 2022. Thus, it can be concluded that there is a significant correlation between the discipline of performing the five-time prayer and the discipline of students in the Medical Study Program at ULM in 2022.
A CORRELATIVE STUDY OF FASTING BLOOD SUGAR, BODY MASS INDEX AND DURATION OF DIABETES WITH FASTING C-PEPTIDE LEVEL IN TYPE 2 DIABETES MELLITUS PATIENTS
Authors: R. Harsoor Vinayshree , Mangshetty Basavaraj
Published: July 2023

Background: Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. It occurs either due to insulin deficiency or insulin resistance. It is an ongoing progressive disorder. The long term complications can be prevented by early screening of diabetes and initiating treatment. Progression of the disease is depicted in the form of worsening hyperglycemia, which may either be due to decreasing secretory activity of beta cells of pancreas or increasing insulin resistance, or in the form of progression of complications. The worldwide prevalence of diabetes mellitus has risen dramatically over the past two decades, from an estimated 30 million cases in 1985 to 415 million in 2017. Adding to this burden is the increasing incidence of type 2 diabetes mellitus. Hence, there is a need to understand the pathophysiology of diabetes, insulin secretion and insulin resistance and overcome them. One such way is to measure beta cell secretory activity. Measurement of C-peptide, which is secreted along with Insulin, provides a better index of endogenous insulin production and pancreatic beta cell function. Materials And Methods: It is a prospective interventional study done by simple random procedure, over a period of 18 months (1st March 2021 to 31st August 2022) with 200 cases. Results: Study reveals that there is no statistically significant difference of mean FBS with Quantile C-peptide levels. But there is statistically significant negative correlation between duration of diabetes and C-peptide levels in the study population (p<0.05). As duration of diabetes increases, C-peptide value decreases. And, there was statistically highly significant positive correlation between BMI and C-peptide levels in the study population (p<0.001). As BMI value increases, C-peptide level also increases. Conclusion: This study suggests that BMI and duration of diabetes are major factors in ÃŸ cell function in people with diabetes.
FAMILY PLANNING KNOWLEDGE, ATTITUDE, AND PRACTICE AMONG POSTNATAL WOMEN IN A TERITIARY CARE CENTER
Authors:   Professor in Department of Obstetrics and Gynaecology, Kurnool Medical College, Kurnool., Srilakshmi A. , Mounika Reddy B. ,   PG in Department of Obstetrics and Gynaecology, Kurnool Medical College, Kurnool., Sudhakar C. ,   Assistant Professor in Department of Obstetrics and Gynaecology, Kurnool Medical College, Kurnool., Ratna Kumari P. ,   Assistant Professor in Department of Obstetrics and Gynaecology, Kurnool Medical College.
Published: July 2023

Background: Family planning methods prevent pregnancy-related health risks for women. Aims and Objectives: The study aims to describe the socio demographic profile, knowledge, awareness, source of information, and utilization of various family planning methods among postnatal women who delivered in a kurnool Government general hospital(teritiary care center) Materials and Methods: It was a cross-sectional study conducted in the Department of Obstetrics and Gynaecology, kurnool Medical College and Hospital, kurnool,ANDHRA PRADESH over a period of 6 month from june 1,2022 to , December 30,2022. â€¢After obtaining informed verbal consent, a predesigned standardized questionnaire was given to 500 postnatal mothers who delivered in the institution either by vaginal or by caesarean section. Data on socio demographic profile, knowledge, awareness of various family planning methods, source of information, utilization, and reasons for non-use were collected and statistical analysis was done using MS Excel. Results were expressed in terms of numbers and percentage. Result: Only 412 (82.4%) of the respondents had heard about family planning. About 65.7% of respondents have good knowledge, 34.3% have poor knowledge. Out of 500 respondents 349 (69.8%) have positive attitude towards contractive and the remaining 151 (30.2%) had negative attitude. Out of 500 respondents 152(30.4%) of respondents had a safe practice and the remaining 348 (69.6%) were unsafe practice towards contraceptive use. Conclusion: In our study â€¢it is evident 65.7% had good knowledge regarding family planning methodsâ€¢Regarding attitude gender bias having male is anasset to family having female child is curse.â€¢This attitude has to be overcome by proper education, counseling to the elligible couple and community by health care professionalâ€¢By this we can impart knowledge, practice regarding family planning methods.
EXPONENTIAL-TIME DIFFERENCING METHOD FOR SOLVING REACTOR POINT KINETICS EQUATIONS WITH TEMPERATURE AND POWER FEEDBACK AND ITS VALIDATION BY ANALYSINGTHERMAL REACTOR BENCHMARKS
Authors:   Bhabha Atomic Research Centre, Visakhapatnam, India., Ravindra Babu P. , Pal Usha ,   Bhabha Atomic Research Centre, Mumbai, India., Karthikeyan R. ,   Bhabha Atomic Research Centre, Mumbai, India., Sen R.N. ,   Bhabha Atomic Research Centre, Mumbai, India., Razak M.M.A. ,   Bhabha Atomic Research Centre, Kalpakkam, India.
Published: July 2023

Exponential Time Differencing method with Taylor Series Expansion (ETD-TS) is used for solving nonlinear systems of point kinetics equations (PKEs). Integral forms of PKE are expanded using Taylor Series Expansion method. Time step value and Taylor series expansion order (n) is chosen to minimize the truncation error.PKEs are highly stiff and nonlinear in nature in presence of thermal feedback. So, advanced method (ETD-TS) is used in the present work to estimate the power transients. Thermal Reactors benchmark with stepandcompensated ramp reactivity insertions are considered for estimation of power transients with feedback. Comparison of results with other accurate numerical methods likeCATS (Convergence Accelerated Taylor Series), SCS (Shifted Chebyshev Series), ITS2 (Integral Taylor Series)etc confirms the validity and accuracy of this method.Time step of 10-2 â€“ 10-4sec is considered for estimationof power and reactivity transients.
A NEW VISION TOWARDS WOMEN EMPOWERMENT IN THE LIGHT OF WOLLSTONECRAFT, NIVEDITA AND NODDINGS
Authors:   Research Scholar, Department of Education, University of Kalyani, Kalyani, Nadia, West Bengal, India., Iqubal Jayed , Bhattacharyya Dibyendu ,   Professor, Department of Education, University of Kalyani, Kalyani, Nadia, West Bengal, India.
Published: July 2023

This paper explores the contributions of three influential thinkers-Mary Wollstonecraft, Sister Nivedita, and NelNoddings-to the vision of womens empowerment. Drawing on their works from different historical periods, the paper examines the commonalities and shared principles underlying their perspectives while also highlighting their distinct contributions. The aim is to provide a comprehensive understanding of a new vision towards women empowerment that integrates their ideas. The analysis begins with an examination of Mary Wollstonecrafts contributions during the 18th century womens empowerment movement. Wollstonecrafts emphasis on education as a means of empowerment, her critique of gender roles and norms, and her advocacy for womens political and legal rights serve as foundational pillars for subsequent discussions. Moving into the 20th century, the paper then delves into Sister Niveditas contributions within the Indian context. Niveditas focus on cultural preservation, recognition of womens agency, and the promotion of self-reliance for Indian women provide a unique perspective on womens empowerment and the intersectionality of culture and gender. The exploration continues with an analysis of NelNoddings work in the 19th century. Noddings brings an ethical dimension to the discussion, emphasizing the importance of empathy, compassion, and caring relationships in empowering women and nurturing their holistic well-being. Drawing upon these three distinct perspectives, the paper identifies commonalities and shared principles, such as the recognition of womens agency, the challenge to gender roles and norms, and the importance of education in empowerment. It also explores the implications of their ideas for contemporary womens empowerment movements, highlighting their continued relevance in addressing ongoing challenges and shaping the pursuit of gender equality. Finally, the paper concludes with reflections on the new vision towards womens empowerment that emerges from the synthesis of these influential thinkers. It highlights the significance of recognizing and valuing diversity, embracing intersectionality, and promoting inclusive and compassionate approaches in empowering women in contemporary society. This paper contributes to the existing literature on womens empowerment by offering a comprehensive exploration of a new vision that draws from the ideas of Wollstonecraft, Nivedita, and Noddings. It underscores the relevance of their contributions in addressing persistent challenges and shaping contemporary efforts towards achieving gender equality and creating a more inclusive and empowering society.
SPECTRUM OF FEBRILE THROMBOCYTOPENIA AMONG CHILDREN IN A TROPICAL COUNTRY: A HOSPITAL BASED OBSERVATIONAL STUDY IN DHAULADHAR REGION
Authors:   MD Pediatrics, Civil Hospital Kangra(H. P)., Kumar Sandeep , Sapehia Akshit ,   MD Pediatrics, Civil Hospital Shahpur(H. P).
Published: July 2023

Background: Pediatric admissions often involve febrile thrombocytopenia. Infections are the main cause however noninfectious reasons occur. This study estimated the prevalence of thrombocytopenia in pediatric fever patients, its etiologies, presentations, and the association between platelet count and disease severity and prognosis. Methods: Retrospective observational study done by collecting data fromhospital records of children admitted inRPGMC Tanda from January 2021 to December 2022. Children in the age group of 6 months to15 years with fever and thrombocytopenia at admission were included in the study. Children on treatment with antiplatelet drugs, other chronic diseases and infants less than 6 months were excluded. Results: 48% had high-grade fever at presentation. Fever averaged 4â€“6 days and peaked at 14 days. Constitutional symptoms (vomiting, abdominal pain) followed. Respiratory and diarrheal manifestations were rare. Seizures and altered sensorium were present in 4%. The next most common clinical finding was hepatomegaly with right hypochondrial tenderness (44%), followed by fluid leak (ascites, pleural effusion) (40%), periorbital puffiness (30%), subcutaneous bleeds (20%), conjunctival congestion (14%) and splenomegaly (14%). Conclusions: Dengue-endemic children have febrile thrombocytopenia. Thrombocytopenia with abdominal pain, vomiting, or oliguria suggests dengue. Enteric fever, scrub typhus, and chikungunya induce similar symptoms. Leukemia, idiopathic thrombocytopenic purpura, hemolytic uremic syndrome, and sepsis can induce febrile thrombocytopenia. Blood and antibiotics are unusual.
INFLUENCE OF JYOTI (LIGHT) MEDITATION ON INTELLIGENCE OF SCHOOL STUDENTS
Authors:   Ph.D. Scholar, Department of Physical Education, Banaras Hindu University, Varanasi, India., Saini Pradip , Onima Reddy T. ,   Professor, Department of Physical Education, Banaras Hindu University, Varanasi, India., Biswas Nitai ,   Ph.D. Scholar, Department of Physical Education, Banaras Hindu University, Varanasi, India., Halder Sajal ,   Ph.D. Scholar, Department of Physical Education, Banaras Hindu University, Varanasi, India., Singh Vikram ,   Professor, Department of Physical Education, Banaras Hindu University, Varanasi, India.
Published: July 2023

Purpose:The purpose of the studies, is to find out the effects of Jyoti meditation on intelligence of school students. Materials and Methods: In this study total of Forty (40) subjects (agesranging from 12 to 14 years) were selected by random sampling technique. after the pre-test, all the subjects were scattered into two equal groups i.e., the Experimental Group (n=20) and Control Group (n=20). The Control Group received no training at all whereas the Experimental Group participated in a Six (6) week Jyoti meditation training programme. Pre-test and post-test were applied to get the data from both groups. Statistical technique: For the analysis of data statistical Mean, Standard Deviation and T-test were used. The level of significance was set at 0.05. Results: The test findings showed the significant ratio value for selected variables in the Experimental Group. The findings of the study revealed that the Six (6) weeks of Jyoti meditation training is very beneficial to increase the intelligence of the school students. Conclusion: Lastly, I concluded that the Jyoti meditation training programme significant effect on the intelligence of school students (Boy & Girl).