bluuebunny/crossref_metadata_2025 huggingface dataset:
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning
Authors: Piel Sarah , Janowska Joanna I. , Ward J. Laurenson , McManus Meagan J. , Jose Joshua S. , Starr Jonathan , Sheldon Malkah , Clayman Carly L. , Elmér Eskil , Hansson Magnus J. , Jang David H. , Karlsson Michael , Ehinger Johannes K. , Kilbaugh Todd J.
Published: November 2022

Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of all pesticide-related deaths. OPs inhibit the enzyme acetylcholinesterase (AChE), which leads to impairment of the central- and peripheral nervous system. Current standard of care (SOC) alleviates acute neurologic-, cardiovascular- and respiratory symptoms and reduces short term mortality. However, survivors often demonstrate significant neurologic sequelae. This highlights the critical need for further development of adjunctive therapies with novel targets. While the inhibition of AChE is thought to be the main mechanism of injury, mitochondrial dysfunction and resulting metabolic crisis may contribute to the overall toxicity of these agents. We hypothesized that the mitochondrially targeted succinate prodrug NV354 would support mitochondrial function and reduce brain injury during acute intoxication with the OP diisopropylfluorophosphate (DFP). To this end, we developed a rat model of acute DFP intoxication and evaluated the efficacy of NV354 as adjunctive therapy to SOC treatment with atropine and pralidoxime. We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure.
Contrast phase recognition in liver computer tomography using deep learning
Authors: Rocha Bruno Aragão , Ferreira Lorena Carneiro , Vianna Luis Gustavo Rocha , Ferreira Luma Gallacio Gomes , Ciconelle Ana Claudia Martins , Da Silva Noronha Alex , Cortez Filho João Martins , Nogueira Lucas Salume Lima , Leite Jean Michel Rocha Sampaio , da Silva Filho Maurício Ricardo Moreira , da Costa Leite Claudia , de Maria Felix Marcelo , Gutierrez Marco Antônio , Nomura Cesar Higa , Cerri Giovanni Guido , Carrilho Flair José , Ono Suzane Kioko
Published: November 2022

Hepatocellular carcinoma (HCC) has become the 4th leading cause of cancer-related deaths, with high social, economical and health implications. Imaging techniques such as multiphase computed tomography (CT) have been successfully used for diagnosis of liver tumors such as HCC in a feasible and accurate way and its interpretation relies mainly on comparing the appearance of the lesions in the different contrast phases of the exam. Recently, some researchers have been dedicated to the development of tools based on machine learning (ML) algorithms, especially by deep learning techniques, to improve the diagnosis of liver lesions in imaging exams. However, the lack of standardization in the naming of the CT contrast phases in the DICOM metadata is a problem for real-life deployment of machine learning tools. Therefore, it is important to correctly identify the exam phase based only on the image and not on the exam metadata, which is unreliable. Motivated by this problem, we successfully created an annotation platform and implemented a convolutional neural network (CNN) to automatically identify the CT scan phases in the HCFMUSP database in the city of São Paulo, Brazil. We improved this algorithm with hyperparameter tuning and evaluated it with cross validation methods. Comparing its predictions with the radiologists annotation, it achieved an accuracy of 94.6%, 98% and 100% in the testing dataset for the slice, volume and exam evaluation, respectively.
Increased abundance of Ruminococcus gnavus in gut microbiota is associated with moyamoya disease and non-moyamoya intracranial large artery disease
Authors: Mineharu Yohei , Nakamura Yasuhisa , Sato Noriaki , Kamata Takahiko , Oichi Yuki , Fujitani Tomoko , Funaki Takeshi , Okuno Yasushi , Miyamoto Susumu , Koizumi Akio , Harada Kouji H.
Published: November 2022

Moyamoya disease (MMD) is a rare cerebrovascular disease endemic in East Asia. The p.R4810K mutation in RNF213 gene confers a risk of MMD, but other factors remain largely unknown. We tested the association of gut microbiota with MMD. Fecal samples were collected from 27 patients with MMD, 7 patients with non-moyamoya intracranial large artery disease (ICAD) and 15 control individuals with other disorders, and 16S rRNA were sequenced. Although there was no difference in alpha diversity or beta diversity between patients with MMD and controls, the cladogram showed Streptococcaceae was enriched in patient samples. The relative abundance analysis demonstrated that 23 species were differentially abundant between patients with MMD and controls. Among them, increased abundance of Ruminococcus gnavus > 0.003 and decreased abundance of Roseburia inulinivorans < 0.002 were associated with higher risks of MMD (odds ratio 9.6, P = 0.0024; odds ratio 11.1, P = 0.0051). Also, Ruminococcus gnavus was more abundant and Roseburia inulinivorans was less abundant in patients with ICAD than controls (P = 0.046, P = 0.012). The relative abundance of Ruminococcus gnavus or Roseburia inulinivorans was not different between the p.R4810K mutant and wildtype. Our data demonstrated that gut microbiota was associated with both MMD and ICAD.
Biomarkers for rhythmic and discrete dynamic primitives in locomotion
Authors: Moura Coelho Rui , Hirai Hiroaki , Martins Jorge , Krebs Hermano Igo
Published: November 2022

Rehabilitation can promote brain plasticity and improve motor control after central nervous system injuries. Our working model is that motor control is encoded using dynamic primitives: submovements, oscillations, and mechanical impedances. We hypothesize that therapies focusing on these primitives can achieve greater motor recovery. At the observational level, these primitives lead to discrete and rhythmic movements. Here, we propose two novel biomarkers to evaluate rhythmic and discrete movements in gait based on the feet forward position: the smoothness of their relative position, using the mean-squared jerk ratio (MSJR), to assess rhythmicity; and the angle between principal components of consecutive trajectories (dPCA), to detect discrete movements amidst rhythmic motion. We applied these methods to kinematic data collected with healthy individuals during experiments employing the MIT-Skywalker: level-ground walking at five speeds, with and without imposed ankle stiffness; walking at constant speed on ascending, descending, and laterally tilted slopes; and performing sidesteps. We found a decrease in MSJR as speed increases, related to increased rhythmicity, even with imposed stiffness. Rhythmicity seems unaffected by the terrain perturbations imposed. Finally, dPCA successfully detects sidesteps, discrete events amidst rhythmic movement. These biomarkers appear to accurately assess rhythmic and discrete movements during walking and can potentially improve clinical evaluation and rehabilitation of neurological patients.
Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia
Authors: Sullivan-Toole Holly , Feng Shengchuang , Carlton Corinne N. , Ghane Merage , Olino Thomas M. , Allen Irving C. , Richey John A.
Published: November 2022

Affective immunology of the skin is a growing area; however, established protocols for measuring individual differences in cutaneous inflammation are lacking. To address this, we present a preliminary validation of Precision Implementation of Minimal Erythema Dose (PI-MED) testing as a method for measuring cutaneous inflammation. PI-MED is a recently adapted protocol, optimized for reproducibility and individual differences research, that uses ultraviolet (UV) light to evoke cutaneous erythema, or inflammatory skin reddening. PI-MED’s novel UV dosage schedule produces standardized erythema responses across different skin pigmentation types and shows strong internal consistency within person and good test–retest reliability across 8–10 weeks. In line with predictions, increased PI-MED erythema was associated with heightened anhedonia, across several measures, beyond influences of non-affective covariates. While future work should further refine the dosage schedule for the lightest and darkest skin types, overall, evidence supports PI-MED as a protocol for inducing and measuring individual differences in cutaneous inflammation. Further, PI-MED-induced erythema can expand psychoneuroimmunology research by offering a complementary assessment for general inflammatory tone. This work adds to a growing body of evidence demonstrating a distinct relationship between inflammation and anhedonia.
Precisely predicting the 1H and 13C NMR chemical shifts in new types of nerve agents and building spectra database
Authors: Jeong Keunhong , Ryu Tae In , Hwang Seung-Ryul , Cho Yoonjae , Lim Kyoung Chan , Yoon Ung Hwi , Lee Jin-Young , Yoon Young Wook , Jeong Hey Jin
Published: November 2022

Following the recent terrorist attacks using Novichok agents and the subsequent decomposition operations, understanding the chemical structures of nerve agents has become important. To mitigate the ever-evolving threat of new variants, the Organization for the Prohibition of Chemical Weapons has updated the list of Schedule 1 substances defined by the Chemical Weapons Convention. However, owing to the several possible structures for each listed substance, obtaining an exhaustive dataset is almost impossible. Therefore, we propose a nuclear magnetic resonance-based prediction method for 1H and 13C NMR chemical shifts of Novichok agents based on conformational and density functional study calculations. Four organophosphorus compounds and five G- and V-type nerve agents were used to evaluate the accuracy of the proposed procedure. Moreover, 1H and 13C NMR prediction results for an additional 83 Novichok candidates were compiled as a database to aid future research and identification. Further, this is the first study to successfully predict the NMR chemical shifts of Novichok agents, with an exceptional agreement between predicted and experimental data. The conclusions enable the prediction of all possible structures of Novichok agents and can serve as a firm foundation for preparation against future terrorist attacks using new variants of nerve agents.
Prevalence of classes 1 and 2 integrons in multidrug-resistant Acinetobacter baumanni isolates recovered from some aquatic environment in South Africa
Authors: Adeniji Oluwaseun Ola , Elsheikh Elsiddig A. E. , Okoh Anthony Ifeanyin
Published: November 2022

The emergence of antibiotic-resistance genes (ARGs) by means of integrons in multidrug-resistant Acinetobacter baumannii (MDR A. baumannii) has become a significant challenge in the management of infections from this pathogen. In this paper, we report on the variable region of class 1 and 2 integrons observed in MDR A. baumanni isolates recovered from rivers in the Eastern Cape Province, South Africa. Class 1 and 2 integrons with their variable regions were evaluated with polymerase chain reaction techniques followed by sequencing. Antibiotic sensitivity testing, checkerboard assay, time-kill independent assay, and Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR) were carried out using standard microbiological techniques. A total of fifty-six (56) isolates were examined, among which 45 (79%) tested positive for class 1 integron, and 7 (12.3%) had class 2 integron. None was found to be class 3 integron positive among the isolates. The variable region contained aadA1, aadA5, and aadA2 genes, which confer resistance against streptomycin and spectinomycin, aac(6′)-Ib against amikacin/ tobramycin and dfrA17 genes against trimethoprim. The minimum inhibitory concentrations of the antimicrobials for one of the tested organisms were resistant against meropenem, colistin sodium methanesulfonate, tetracycline, ceftazidime, and ciprofloxacin (16, > 16, > 8, > 256, and 128 ug/mL respectively). The impact of colistin combined with quinolones (ciprofloxacin), with the FICIs (0.31) indicated synergistic effects against MDR A baumanni. However, when colistin was combined with meropenem and ceftazidime, additive effects with fractional inhibitory concentration (FIC) index ranging from 0.52 to 1 were observed. No antagonistic effect was evaluated among the examined isolates. ERIC-PCR analyses of A. baumanni isolates revealed significant genetic diversity, suggesting various sources of environmental contamination. We conclude that A. baumanni harbouring class 1 integrons in aquatic milieus are a significant source of ARGs and can transmit these elements to other organisms and consequently to man with significant public health implications.
First-principle calculations of sulfur dioxide adsorption on the Ca-montmorillonite
Authors: Fang Zhi-Jie , Song Chang-Hui , Liu Mei-Ling , Li Bo , Lin Shi-Kai , Lin Xiong-San , Zhou Xiang , He Qiu-Zhi , Mo Man
Published: November 2022

According to the serious problem of sulfur dioxide pollution, montmorillonite is one of the effective ways in gas pollution control because of its excellent absorption properties. One of the fundamental questions is to fully understand sulfur dioxide absorption mechanism of montmorillonite. In this study, using the first-principle methods, we studied the adsorption characteristics of Ca-montmorillonite in the presence of $$\hbox {SO}_{{2}}$$

SO
2

. The adsorption energy and elasticity constants as a function of the adsorption capacity were also studied. The calculated results show that bridge site is the most stable adsorption site for $$\hbox {SO}_{{2}}$$

SO
2

with the adsorption energy of − 140 meV. As adsorbent, Ca-montmorillonite is a clay with layer-structure, most of bond lengths(such as Al–O, Mg–O, Si–O, and H–O) does not obviously change. As adsorbed gas, the O–S–O bond angle of adsorbed $$\hbox {SO}_{2}$$

SO
2

change from $$119.50^\circ$$

119
.

50
∘

to $$115.32^\circ$$

115
.

32
∘

. The volume and adsorption energies of Ca-montmorillonite almost increase linearly with increasing $$\hbox {SO}_{{2}}$$

SO
2

adsorption. By calculating the montmorillonite elasticity constants under different adsorption capacity, we found that the elasticity constant C33 which perpendicular to the crystal face, with the maximum changes from 450 to 326 GPa. In addition, Young’s modulus,bulk modulus and shear modulus significantly decrease with the increasing adsorption. The calculated results will not only help to understand the physical and chemical of montmorillonite but may also provide theoretical guidance for dealing with the problem of gas pollution.
Feasibility of using breath sampling of non-volatiles to estimate the prevalence of illicit drug use among nightlife attendees
Authors: Feltmann Kristin , Elgán Tobias H. , Böttcher Michael , Lierheimer Stefan , Hermansson Sigurd , Beck Olof , Gripenberg Johanna
Published: November 2022

The prevalence of drug use among nightlife attendees needs to be accurately estimated to, for example, evaluate preventive interventions. This study tested the feasibility of using a breath-sampling device to estimate the prevalence of drug use among nightlife attendees. The study was conducted at five nightclubs and a large music festival in Stockholm, Sweden. Participants were invited to participate and microparticles in exhaled breath were sampled and analyzed for 47 compounds using a state-of-the-art analytic method that follows forensic standards. In addition, participants’ breath alcohol concentration was measured and they were interviewed about demographics, drinking habits, and drug use. Of the people invited, 73.7% (n = 1223) agreed to participate, and breath samples were collected from 1204 participants. Breath sampling was fast and well-accepted by participants. 13 percent of participants tested positive for an illicit drug, but only 4.3% self-reported drug use during the last 48 h. The most common substances detected were cocaine, amphetamine, and MDMA. There was no agreement between self-reported and measured use of any drug. Breath sampling is a convenient method to test illicit drug use among a large number of participants at events, and can be used as an estimate of drug use prevalence.
The clinical impact of donor against recipient HLA one way mismatch on the occurrence of graft versus host disease in liver transplantation
Authors: Kim Sang Jin , Park Sunghae , Rhu Jinsoo , Kim Jong Man , Choi Gyu-Seong , Joh Jae-Won
Published: November 2022

Graft versus host disease (GVHD) after liver transplantation (LT) is a rare, fatal disease. This study aimed to evaluate the risk factors of GVHD after LT including the human leukocyte antigen (HLA) donor-recipient relationship after LT. LT recipients, who underwent HLA typing together with donors, were included in the study. The donor against recipient (D → R) one-way mismatch of HLA loci was evaluated. HLA relationships, along with basic characteristics, were analyzed as variable factors of GVHD, graft survival, and patient survival. A total of 994 living donor LT (LDLT) and 393 deceased donor LT (DDLT) patients were included. Nine patients had suffered GVHD, four LDLT with D → R one-way at three loci, one LDLT without D → R one-way at three loci, and four DDLT without D → R one-way at three loci. Four (57.1%) of seven LDLT patients, with D → R one-way mismatch at three loci, developed GVHD. D → R one-way mismatch at three loci was related to high GVHD incidence (HR 787, p < 0.001, multivariate). D → R one-way mismatch at three loci was related to graft failure and patient death (HR 9.90, p = 0.020 and HR 12.8, p < 0.001, respectively, multivariate). Only one GVHD without D → R one-way mismatch at three loci, survived despite receiving multiple modalities including tumor necrosis factor-alpha inhibitors. D → R one-way mismatch at three loci was significantly related to GVHD incidence after LT.
Machine learning modeling of predictive external corrosion rates of spent nuclear fuel carbon steel canister in soil
Authors: Nguyen Thuy Chung , So Yoon-Sik , Yoo Jin-Soek , Kim Jung-Gu
Published: November 2022

Soil corrosion is always a critical concern to corrosion engineering because of the economic influence of soil infrastructures as has been and has recently been the focus of spent nuclear fuel canisters. Besides corrosion protection, the corrosion prediction of the canister is also important. Advanced knowledge of the corrosion rate of spent nuclear fuel canister material in a particular environment can be extremely helpful in choosing the best protection method. Applying machine learning (ML) to corrosion rate prediction solves all the challenges because of the number of variables affecting soil corrosion. In this study, several algorithms of ML, including series individual, boosting, bagging artificial neural network (ANN), series individual, boosting, bagging Chi-squared automatic interaction detection (CHAID) tree decision, linear regression (LR) and an ensemble learning (EL) merge the best option that collects from 3 algorithm methods above. From the performance of each model to find the model with the highest accuracy is the ensemble stacking method. Mean absolute error performance matrices are shown in Fig. 15. Besides applying ML, the significance of the input variables was also determined through sensitivity analysis using the feature importance criterion, and the carbon steel corrosion rate is the most sensitive to temperature and chloride.
Characteristics of road traffic mortality and distribution of healthcare resources in Thailand
Authors: Seresirikachorn Kasem , Singhanetr Panisa , Soonthornworasiri Ngamphol , Amornpetchsathaporn Anyarak , Theeramunkong Thanaruk
Published: November 2022

Road traffic mortalities (RTMs), a leading cause of death globally, mostly occur in low- and middle-income countries, and having sufficient healthcare resources could lower the number of these fatalities. Our study aimed to illustrate the incidence of RTMs per 100,000 population and to compare the distribution of healthcare resources from 2011 to 2021 with rates of RTMs in the 77 provinces of Thailand. We divided the population into adults (≥ 15 years) and children (0–14 years). Lorenz curve and Gini coefficient were used to measure the level of distribution and equality of hospital resources and in relation to RTMs across the country. The average number of deaths was 30.34 per 100,000 per year, with male predominance. The RTM rates for adults and children were 32.71 and 19.08 per 100,000 respectively, and motorcycle accidents accounted for the largest percentage of deaths across all age groups. The Gini coefficient showed that operating rooms (0.42) were the least equally distributed hospital resource, while physicians were the most equally distributed (0.34). Anomalies were identified between the distribution of RTMs and available hospital resources. We hope our study will be beneficial in reallocating these resources more fairly to reflect the different numbers of traffic accidents in each province with the aim of reducing lower traffic-related deaths.
Fear of hypoglycemia and associated factors in hospitalized patients with type 2 diabetes: a cross‑sectional study
Authors: Huang Jing , Peng Wei , Ding Shenglan , Xiong Shuyuan , Liu Zhiping
Published: November 2022

The present cross-sectional survey was performed to assess the prevalence and factors associated with fear of hypoglycemia (FoH) in hospitalized patients with type 2 diabetes (T2D). Between July and December 2020, 494 patients with T2D were evaluated via structured questionnaires containing sociodemographic information, clinical information, and the Fear of Hypoglycemia-15 scale (FH-15). Patients were divided into the FoH and non-FoH groups according to the FH-15 score. Univariate and multivariate logistic regression analyses were performed to determine factors associated with FoH. Variables with P values < 0.1 in the univariate model were included in the multivariate model. In this study, the prevalence of FoH was 17.4% (86/494). 247 (50.0%) patients experienced hypoglycemic episodes in the past year, and 15 (3.0%) patients experienced severe hypoglycemic episodes in the past year. The mean age was 60.04 ± 11.71 years old, and female patients accounted for 39.9% of the sample. The item with the highest average FH-15 scores was: how often are you afraid of having hypoglycemia while alone? Multivariate logistic regression analysis indicated that living alone (OR 2.48; 95% CI 1.20–5.14; P = 0.015), number of hypoglycemic episodes in the past year (OR 1.06; 95% CI 1.03–1.10; P < 0.001), number of severe hypoglycemic episodes in the past year (OR 2.61; 95% CI 1.20–5.69; P = 0.016), and duration of insulin use (OR 1.06; 95% CI 1.02–1.10; P = 0.006) were associated with FoH. The prevalence of FoH in hospitalized patients with T2D was high. FoH was associated with living alone, number of hypoglycemic episodes in the past year, number of severe hypoglycemic episodes in the past year, and duration of insulin use. These findings can contribute to early decision-making for preventing, identifying, and improving FoH in patients with T2D. In the future, interventions aimed at reducing FoH to improve the harmful effects of FoH are necessary, such as increasing diabetes-related knowledge and skills, increasing social support, reducing psychological fear, and minimizing risks for hypoglycemic episodes.
Effect of food cues on time perception: influence of calories and diet control
Authors: Hallez Quentin , Filippone Lisa , Shankland Rebecca
Published: November 2022

The aim of this study was to investigate the influence on individuals’ time perception of observing a range of foods differing in calorific content. In a first experiment, 92 adult participants performed a temporal bisection task with stimulus durations presented in the form of high- or low-calorie food pictures as well as matched non-food control pictures. In a second experiment, 102 participants performed a strict replication of Experiment 1, without the low-calorie pictures condition as it showed less pronounced effects. Across the two experiments, the data revealed common results. An overestimation of time was observed in relation to high-calorie food pictures when compared with non-food pictures (Experiment 2), and the effect was a function of participants' diet control (Experiments 1 & 2). Contrary to our hypothesis, the more the participants reported controlling their diet, the less they overestimated the time when presented with food stimuli. The participants who controlled their diet reported being less aroused by the high-calorie food pictures, allowing the assumption that the modulation in time overestimation relies on the arousal response generated by high-calorie food pictures.
A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway
Authors: Wang Jing , Xie Jingjing , Chen Haixia , Qiu Xia , Cui Hai , Liu Yijiang , Sahu Sunil Kumar , Fang Dongming , Li Tengyan , Wang Mei , Chen Yewen , Liu Huan , Zhang Jianyong , Wang Binbin
Published: November 2022

Cremastra appendiculata (D. Don) Makino is a rare terrestrial orchid with a high market value as an ornamental and Chinese traditional medicinal herb with a wide range of pharmacological properties. The pseudobulbs of C. appendiculata are one of the primary sources of the famous traditional Chinese medicine “Shancigu”, which has been clinically used for treating many diseases, especially, as the main component to treat gout. The lack of genetic research and genome data restricts the modern development and clinical use of C. appendiculata. Here, we report a 2.3 Gb chromosome-level genome of C. appendiculata. We identify a series of candidates of 35 candidate genes responsible for colchicine biosynthesis, among which O-methyltransferase (OMT) gene exhibits an important role in colchicine biosynthesis. Co-expression analysis reveal purple and green-yellow module have close relationships with pseudobulb parts and comprise most of the colchicine pathway genes. Overall, our genome data and the candidate genes reported here set the foundation to decipher the colchicine biosynthesis pathways in medicinal plants.
Organ of Corti vibrations are dominated by longitudinal motion in vivo
Authors: Meenderink Sebastiaan W. F. , Dong Wei
Published: November 2022

Recent observations of sound-evoked vibrations of the cochlea’s sensory organ of Corti (ooC) using optical coherence tomography (OCT) have revealed unanticipated and complex motions. Interpreting these results in terms of the micromechanical inner-ear processes that precede hair-cell transduction is not trivial since OCT only measures a projection of the true motion, which may include transverse and longitudinal displacements. We measure ooC motions at multiple OCT beam angles relative to the longitudinal axis of the basilar membrane (BM) by using the cochlea’s natural curvature and find that the relative phase between outer hair cells (OHC) and BM varies with this angle. This includes a relatively abrupt phase reversal where OHC lead (lag) the BM by ~0.25 cycles for negative (positive) beam angles, respectively. We interpret these results as evidence for significant longitudinal motion within the ooC, which should be considered when interpreting (relative) ooC vibrations in terms of inner-ear sound processing.
Steering interface effect of H-ZSM-5 zeolites with tailored surface barriers to improve their catalytic performances
Authors: Liu Xiaoliang , Wang Yu , Zhou Jian , Wang Chuanming , Shi Jing , Ye Yingchun , Wang Yangdong , Teng Jiawei , Xie Zaiku
Published: November 2022

An efficient H-ZSM-5 zeolite interface with optimized surface diffusion barriers was tailored by passivating the hydroxyl-group defects at surfaces or near pore mouths, resulting in significant improvement in catalytic cracking performances.
Effect of rare-earth (RE) ionic radius on the dielectric properties of Sr99%RE1%TiO3 (RE = La, Nd, Yb) single crystals
Authors: Wang Lei , Liu Xudong , Li Jinsheng , Zhang Mu , Bi Xiaoguo , Ma Zhixin , Chen Jialin , Sun Xudong
Published: November 2022

Sr99%RE1%TiO3 crystals were prepared by Verneuil method and their dielectric properties were studied. The simultaneous substitution of Sr2+ and Ti4+ may be able to obtain superior dielectric properties compared to the substitution of Sr2+ only.
Entropic contributions to the stability of electrochemically adsorbed anion layers on Au(111): a microcalorimetric study
Authors: Schönig Marco , Schuster Rolf
Published: November 2022

The entropy of formation of an electrochemical interface contains information on its structure, order and composition. We measure it for anion adsorption on Au(111) by electrochemical microcalorimetry.
One-step co-electrodeposition of SnBi for efficient electrochemical reduction of carbon dioxide to formic acid
Authors: Yang Shuaipeng , Sun Yuan , Wang Chunlai , Lv Li , Hu Mengxiang , Jin Junsu , Xie Hangxin
Published: November 2022

With the industrial development and improvement of living standards, carbon dioxide emissions are increasing year on year and have been causing serious environmental issues, such as global warming.
N-Haloimide-enabled halogenationviahalogen-bond-assisted C–C activation of alkanols
Authors: Geng Yan , Ma Yue , Huang Rui , Li Xingwei , Yu Songjie
Published: November 2022

The halogen-bond-assisted C–C activation of alkanols to synthesize a library of alkyl halides in the absence of catalysts and oxidants is disclosed, wherein inexpensiveN-haloimides were explored as bifunctional reagents.
Flexible-in-rigid polycrystalline titanium nanofibers: a toughening strategy from a macro-scale to a molecular-scale
Authors: Fu Wanlin , Xu Wanlin , Yin Kuibo , Meng Xiangyu , Wen Yujie , Peng Luming , Tang Mingyu , Sun Litao , Sun Yueming , Dai Yunqian
Published: November 2022

Electrospun TiO2 nanofibers could be reinforced from a macro-scale to a molecular-scale, by promoting length–diameter ratio, suppressing crystal sintering, repairing surface grooves, constructing lubrication zones, and toughening chemical bonds.
Enhancing magneto-ionic effects in cobalt oxide films by electrolyte engineering
Authors: Martins Sofia , Ma Zheng , Solans-Monfort Xavier , Sodupe Mariona , Rodriguez-Santiago Luis , Menéndez Enric , Pellicer Eva , Sort Jordi
Published: November 2022

Electrolyte engineering by adding salts to propylene carbonate (PC) leads to enhanced voltage-controlled ON–OFF ferromagnetism via oxygen ion motion in electrolyte-gated Co3O4 films. 35-fold faster magneto-ionic rate is achieved in KI-containing PC.
Easy access to Ugi-derived isatin-peptoids and their potential as small-molecule anticancer agents
Authors: Marques Carolina S. , González-Bakker Aday , Padrón José M. , Burke Anthony J.
Published: November 2022

A remarkable Ugi4CR approach to access a library of isatin-based α-acetoamide carboxamide oxindole derivatives with promising antiproliferative activity.
Carbon-based dot-capped gold nanoparticles hybridized with manganese dioxide for enhanced photodynamic cancer therapy
Authors: Hu Rongjing , Guo Tianmin , Zeng Chenyi , Chen Mingming , Zhu Xiajun , Chen Lichan , Dong Yongqiang , Fu FengFu
Published: November 2022

Composite material nanohybrids (FA/MnO2/CDs@AuNPs/CDs) have been synthesized and proven to be excellent photosensitizers for photodynamic therapy applications.
An off-on-off fluorescence probe based on a pyrazole derivative for Al3+ and Fe3+ detection
Authors: Wei Kehui , Lyu Sheyun , Liu Yuanying , Kang Mingyi , Liu Peng , Yang Xiaofeng , Pei Meishan , Zhang Guangyou
Published: November 2022

A multifunctional fluorescence probe (L) was synthesized and used as a dual sensing platform for detecting Al3+ and Fe3+.
Heterointerface engineering constructs microenvironment enhancing catalytic kinetics of Fe/Ni oxyhydroxide@FeNi alloy for overall water splitting
Authors: Ma Kewen , Chang Xueru , Deng Renchao , Wu Xiao , Wang Zehua , Yang Hao
Published: November 2022

The constructed FeNi alloys/oxyhydroxide heterointerface with modulated microenvironment significantly enhanced the surface catalytic kinetics for HER and OER.
Efficient interlayer confined nitrate reduction reaction and oxygen generation enabled by interlayer expansion
Authors: Zhang Ye , Xu Mengqiu , Xu Xudong , Li Xiaoyu , Zhu Genping , Jia Gan , Yang Bingchuan , Yin Ruilian , Gao Peng , Ye Wei
Published: November 2022

The interlayer confined nitrate reduction reaction (NTRR) and oxygen evolution reaction (OER) were realized. The expanded interlayer spacing facilitatesin situK+intercalation. Fe-doped Ni(OH)2delivers excellent functionality in NTRR overall electrocatalysis.
High-yield fabrication of electromechanical devices based on suspended Ti3C2Tx MXene monolayers
Authors: Bagheri Saman , Abourahma Jehad , Lu Haidong , Vorobeva Nataliia S. , Luo Shengyuan , Gruverman Alexei , Sinitskii Alexander
Published: November 2022

We demonstrate a high-yield fabrication of electromechanical devices based on suspended monolayer Ti3C2Tx MXene flakes. The MXene membranes were electrostatically actuated over multiple cycles and with different frequencies, amplitudes, and loads.
Mucus-inspired organogel as an efficient absorbent and retention agent for volatile organic compounds
Authors: Han Jihoon , Lee Jemin , Kim Seonghyeon , Lee Anna , Park Hyung Gyu , Kim Youn Soo
Published: November 2022

Nasal mucus plays a key role in the sense of smell by absorbing and transporting chemicals to olfactory receptors.
A universal approach to ‘host’ carbon nanotubes on a charge triggered ‘guest’ interpenetrating polymer network for excellent ‘green’ electromagnetic interference shielding
Authors: Manna Kunal , Sen Gupta Ria , Bose Suryasarathi
Published: November 2022

Charge triggering of zwitterionic interpenetrating polymeric network-based membranes has been demonstrated to host high content of counter-charged CNTs to make a mechanically resilient IPN-CNT construct through electrostatic assembly.
Catalytic enantioselective desymmetrization ofmeso-aziridines
Authors: Yang Pei-Jun , Chai Zhuo
Published: November 2022

Over the past three decades, the catalytic enantioselective desymmetrization ofmeso-aziridines has evovled to be a ready synthetic toolkit for efficient construction of diverse useful nitrogen-containing molecules bearing contiguous stereocenters.
Synthesis of lightly branched ultrahigh-molecular-weight polyethylene using cationic benzocyclohexyl nickel catalysts
Authors: Yan Zhengpeng , Chang Guanru , Zou Wenping , Luo Gen , Dai Shengyu
Published: November 2022

The ultra-fast chain propagation rate in this contribution can simultaneously promote an increase in molecular weight and a decrease in branching density to achieve lightly branched UHMWPEs (Mn up to 1846 kg mol−1).
Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly
Authors: Oliveira Andreia S. R. , Pereira Patrícia , Mendonça Patrícia V. , Fonseca Ana C. , Simões Sérgio , Serra Arménio C. , Coelho Jorge F. J.
Published: November 2022

Well-defined amphiphilic biodegradable block copolymers (BCPs) are promising materials as drug/gene carriers because they can self-assemble in aqueous medium and form various nanostructures.
Interlayer engineering in V6O13 nanobelts toward superior Mg-ion storage
Authors: Kong Huabin , Ou Jianxin , Chen Lu , Sun Wenlu , Fu Fang , Zhang Hui , Chen Hongwei
Published: November 2022

The interlayer spacing of V6O13 was adjusted by polyaniline intercalation for the first time to accelerate Mg2+ transport kinetics.
An iron-catalysed radical cyclization/C(sp3)–H alkylation cascade between γ,δ-unsaturated oxime esters and glycine derivatives: access to pyrroline-containing amino acids
Authors: Yu Fangyuan , Yang Sen , Xie Zihao , Lu Dengfu , Gong Yuefa
Published: November 2022

An iron-catalysed and ligand-controlled selective α-C–H alkylation ofN-aryl glycinates is established with γ,δ-unsaturated oxime esters as the reagent. This method provides a facile synthetic approach to obtain pyrroline-containing amino acids.
Diacetyliminoxyl as a selective radical reagent for organic synthesis: dehydrogenation and dehydrogenative C–O coupling reactions
Authors: Budnikov Alexander S. , Krylov Igor B. , Kuzmin Ilya V. , Segida Oleg O. , Lastovko Andrey V. , Shevchenko Mikhail I. , Nikishin Gennady I. , Terent'ev Alexander O.
Published: November 2022

Diacetyliminoxyl is introduced as the first synthetically available oxime radical for fundamental mechanistic studies, oxidative functionalization and dehydrogenation processes.
Generation of novel Diels–Alder reactions using a generative adversarial network
Authors: Li Sheng , Wang Xinqiao , Wu Yejian , Duan Hongliang , Tang Lan
Published: November 2022

We obtained 1441 novel reactions by using a generative adversarial network for reaction generation.
Smart biomaterials for enhancing cancer therapy by overcoming tumor hypoxia: a review
Authors: Salim Samar A. , Salaheldin Taher A. , Elmazar Mohamed M. , Abdel-Aziz A. F. , Kamoun Elbadawy A.
Published: November 2022

Hypoxia is a distinctive feature of most solid tumors due to insufficient oxygen supply of the abnormal vasculature, which cannot work with the demands of the fast proliferation of cancer cells.
Engineering of metal–organic framework nanomaterials on long-period fiber grating for acetone vapor sensing
Authors: Wang Haishi , Deng Guowei , Dong Lianghai , Zhao Ke , Chen Kaixin , Chiang Kin Seng , Wu Jieyun
Published: November 2022

The long-period fiber grating was functionalized with metal–organic framework nanomaterial ZIF-8 for sensitive acetone vapor sensing with large dynamic range and fast response.
A novel bimetallic MOFs combined with gold nanoflakes in electrochemical sensor for measuring bisphenol A
Authors: Nguyen Manh B. , Anh Nguyen Hai , Thi Thu Vu , Thi Hai Yen Pham , Hong Phong Pham , Quoc Hung Le , Ngan Nguyen Thi Thanh , Hai Tran Quang , Thi Thu Ha Vu
Published: November 2022

This work demonstrated the fabrication of bimetallic Fe–Cu-BTC which able to provide large surface area, good electrocatalytic efficiency in combination with gold nanoparticles (flakes shapes) in order to detect bisphenol A in water samples.
Wide-bandgap polymer donors for non-fullerene organic solar cells
Authors: Cao Jiamin , Yi Lifei , Zhang Lixiu , Zou Yingping , Ding Liming
Published: November 2022

Herein, we summarize the recent progress of wide-bandgap polymer donors for non-fullerene organic solar cells and classify them into five categories. Also, perspectives on organic photovoltaics are highlighted.
Correction: Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes
Authors: Yu Shijiang , Yu Hongliu , Si Panpan , Wang Zhen , Wang Bing , Lin Wenxin
Published: November 2022

Correction for ‘Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes’ by Shijiang Yu et al., J. Mater. Chem. B, 2022, 10, 8988–8995, https://doi.org/10.1039/D2TB01619B.
Identification of distinctive structural and optoelectronic properties of Bi2O3 polymorphs controlled by tantalum addition
Authors: Saito Taro , Ahmad Rafia , Kishimoto Fuminao , Higashi Tomohiro , Katayama Masao , Cavallo Luigi , Takanabe Kazuhiro
Published: November 2022

The crystal structure and the resultant electronic structure of Ta-supplemented bismuth oxides were altered with the amount of Ta added. Their optoelectronic and redox properties were elucidated both experimentally and theoretically.
Highly stable and air-resistant photonic upconversion organogels with self-healing and temperature responsiveness
Authors: Liu Xiaoyu , He Qin , Pan Jiageng , Liang Hui , Rehmat Noreen , Gao Liang , Huo Yanping , Ji Shaomin
Published: November 2022

Effective triplet–triplet annihilation photon upconversion (TTA-UC) is achieved under aerobic conditions by encapsulation of sensitizers and emitters in alkyl side chain modified PVA.
Platelet concentrates in periodontics: review of in vitro studies and systematic reviews
Authors: Anegundi Raghavendra Vamsi , Shenoy Santhosh B. , Kaukab Syeda Faiza , Talwar Avaneendra
Published: November 2022

Clot formation is the first step of the healing process, and clinical procedures always find ways to stabilize this clot better. Platelets play a significant role in clot formation, and Platelet Concentrates (Pc) are an abundant reservoir of platelets. This article aims to review the in vitro research and systematic reviews on PCs that are currently available. Broadly, PCs mainly include Platelet-rich plasma and platelet-rich fibrin. PCs are an excellent source for growth factors such as PDGF-AA, TGF β1, VEGF, EGF, and IGF. Numerous systematic reviews and meta-analyses have analyzed the clinical application of PCs in various periodontal procedures. In alveolar ridge preservation, PCs are known to reduce postoperative pain, edema, trismus, and inflammation. PRF had shown significant improvement in achieving root coverage and recession depth reduction. PCs exhibited a positive influence on CAL gain when used as an adjunct to OFD in treating infra-bony defects. Pcs have a positive effect on bone maturation in the short term. Besides, PCs can be used in regenerative endodontics, treatment of medication-related osteoradionecrosis of Jaw (MRONJ), and accelerating tooth movement. In conclusion, PCs positively affect soft tissue healing, while their role in hard tissue healing is still unclear.
Evaluation on the quality of Malaysian refined palm stearin
Authors: Ahmad Bustamam Farah Khuwailah , Yeoh Chee Beng , Sulaiman Najwa , Saw Mei Huey
Published: November 2022

The quality of Malaysian palm stearin was monitored through a twelve-month survey in 2018, by participation of palm oil refineries and oleochemical plants from Peninsular Malaysia and Sarawak. Quality parameters requirement as listed in the Palm Oil Refinery Association of Malaysia (PORAM) specification such as moisture, impurities, free fatty acids, slip melting point, peroxide value and iodine value were determined. Other identity characteristics analyses as detailed in the palm stearin specification namely Malaysian Standard MS 815:2007 and Codex Alimentarius CXS 210-1999 documents were also analyzed, which were apparent density, refractive index, fatty acids composition, triacylglycerols, etc. Results obtained from this survey indicated that the quality of Malaysian palm stearin complied with the requirements specified in MS 815:2007 and Codex CXS 210-1999 documents. The iodine value determined was ranged from 28 g I2/100 g oil to 48 g I2/100 g oil, with 60.9% of the palm stearin tested were in the range of 30 g I2/100 g oil to 35 g I2/100 g oil. Meanwhile, some deviations are found in the average of parameter such as refractive index, apparent density, slip melting point, oleic and palmitic acids of the palm stearin produced. These deviations could be due to the improvement in current fractionation technologies causing less olein entrainment in stearin products, which resulted of harder stearin fraction in the sample itself, giving a more representative reading of the parameters.
Transmutex, concepteur de réacteur hybride
Authors: Le Gros Gaïc
Published: November 2022

L’entreprise Transmutex porte le projet « Start », un réacteur hybride piloté par un accélérateur de particules. Une technologie à fort potentiel de transmutation qui pourra contribuer à décarboner l’économie tout en réduisant le volume et la radiotoxicité des déchets.
Les start-up du nucléaire connaissent leurs classiques
Authors: Carré Frank
Published: November 2022

Les projets portés par les quelque 70 start-up nucléaires dans le monde s’inscrivent dans le prolongement de filières de réacteurs dont les premières réalisations, expérimentales ou prototypes, remontent aux années 1950 et 1960.
Early loss of radiographic reduction after acute acromioclavicular joint reconstruction: Comparison of open Double Endobutton fixation vs. Nottingham Surgilig
Authors: Saraglis Georgios , Chaudhari Harsh , Sanjani Shahrukh Reza , Khan Anwar
Published: November 2022

Introduction: Surgical treatment is usually recommended for the acute unstable acromioclavicular joint (ACJ) dislocations. Among the wide variety of different surgical techniques, the Double Endobutton and the Nottingham Surgilig technique are two of the most widely acceptable and well described techniques. The aim of this study was to offer a direct comparison of the above techniques in question, analysing the patients outcomes and assessing the risk of early loss of radiographic reduction. Materials and methods: A total of 48 patients who met the inclusion criteria were included in the study. Patients were categorised in two groups (Endobutton and Nottingham Surgilig group) and post operative assessment of the patients was performed using the Oxford Shoulder (OSS) and Constant Murley (CMS) scores. Patient demographics, hand dominance, ACJ classification and co-morbidities were included in the analysis and radiographic evaluation was conducted for both groups. Results: Both techniques provide a good outcome in the management of unstable ACJ dislocations but the risk of early radiographic failure remains higher in the double Endobutton technique (26% vs. 17.39% for the Nottingham Surgilig group). Factors such as patients’ demographics, hand dominance, co-morbidities and grade of ACJ separation do not seem to contribute to radiographic loss of reduction, whereas the incorrect positioning of the coracoid endobutton is a significant factor predisposing to early radiographic failure, P < 0.001. Discussion: The incidence of early loss of radiographic reduction still remains high in both groups. In order to reduce this common complication, accurate placement of the coracoid endobutton under fluoroscopic intra-operative control is strongly recommended.
Wenn der ältere Hund „sich verliert“
– ein phytotherapeutischer Fallbericht
Authors: Thoonsen Yvonne
Published: November 2022

Demenz bei Tieren? In Zeiten, in denen vierbeinige Begleiter oftmals ein
stattliches Alter erreichen, ist dieser Befund durchaus keine Seltenheit mehr.
Wie sich die Symptome beim älteren Hund äußern
können und welche Phytotherapeutika das Potenzial haben, diese zu
lindern und das Fortschreiten der Erkrankung zu verlangsamen, ist Thema des
folgenden Fallberichts.
Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/050, May 2022)
Authors: Toth Bettina , Bohlmann Michael , Hancke Katharina , Kuon Ruben , Nawroth Frank , von Otte Sören , Rogenhofer Nina , Rudnik-Schöneborn Sabine , Schleußner Ekkehard , Tempfer Clemens , Vomstein Kilian , Wischmann Tewes , von Wolff Michael , Würfel Wolfgang , Zschocke Johannes
Published: November 2022

Purpose The aim of this guideline is to standardize the diagnosis and therapy of recurrent miscarriage (RM) using evidence from the recent literature. This is done by using consistent definitions, objective evaluations and standardized treatment protocols.

Methods When this guideline was compiled, special consideration was given to previous recommendations in prior versions of this guideline and the recommendations of the European Society of Human Reproduction and Embryology, the Royal College of Obstetricians and Gynecologists, the American College of Obstetricians and Gynecologists and the American Society for Reproductive Medicine, and a detailed individual search of the literature about the different topics was carried out.

Recommendations Recommendations about the diagnostic and therapeutic procedures offered to couples with RM were developed based on the international literature. Special attention was paid to known risk factors such as chromosomal, anatomical, endocrinological, physiological coagulation, psychological, infectious and immune disorders. Recommendations were also developed for those cases where investigations are unable to find any abnormality (idiopathic RM).