bluuebunny/crossref_metadata_2025 huggingface dataset:
Genotype-Corrector: improved genotype calls for genetic mapping in F2 and RIL populations
Authors: Miao Chenyong , Fang Jingping , Li Delin , Liang Pingping , Zhang Xingtan , Yang Jinliang , Schnable James C. , Tang Haibao
Published: June 2018

F2 and recombinant inbred lines (RILs) populations are very commonly used in plant genetic mapping studies. Although genome-wide genetic markers like single nucleotide polymorphisms (SNPs) can be readily identified by a wide array of methods, accurate genotype calling remains challenging, especially for heterozygous loci and missing data due to low sequencing coverage per individual. Therefore, we developed Genotype-Corrector, a program that corrects genotype calls and imputes missing data to improve the accuracy of genetic mapping. Genotype-Corrector can be applied in a wide variety of genetic mapping studies that are based on low coverage whole genome sequencing (WGS) or Genotyping-by-Sequencing (GBS) related techniques. Our results show that Genotype-Corrector achieves high accuracy when applied to both synthetic and real genotype data. Compared with using raw or only imputed genotype calls, the linkage groups built by corrected genotype data show much less noise and significant distortions can be corrected. Additionally, Genotype-Corrector compares favorably to the popular imputation software LinkImpute and Beagle in both F2 and RIL populations. Genotype-Corrector is publicly available on GitHub at https://github.com/freemao/Genotype-Corrector.
Electrophysiological evidence of RML12 mosquito cell line towards neuronal differentiation by 20-hydroxyecdysdone
Authors: Gaburro Julie , Duchemin Jean-Bernard , Paradkar Prasad N. , Nahavandi Saeid , Bhatti Asim
Published: June 2018

Continuous cell lines from insect larval tissues are widely used in different research domains, such as virology, insect immunity, gene expression, and bio pharmacology. Previous study showed that introduction of 20-hydroxyecdysone to Spodoptera cell line induced a neuron-like morphology with neurite extensions. Despite some results suggesting potential presence of neuro-receptors, no study so far has shown that these neuron-induced cells were functional. Here, using microelectrode arrays, we showed that the mosquito cell line, RML12, differentiated with 20-hydroxyecdysone, displays spontaneous electrophysiological activity. Results showed that these cells can be stimulated by GABAergic antagonist as well as nicotinic agonist. These results provide new evidence of neuron-like functionality of 20-hydroxyecdysone induced differentiated mosquito cell line. Finally, we used this new model to test the effects of two insecticides, temephos and permethrin. Our analysis revealed significant changes in the spiking activity after the introduction of these insecticides with prolonged effect on the neuronal activity. We believe that this differentiated mosquito neuronal cell model can be used for high-throughput screening of new pesticides on insect nervous system instead of primary neurons or in vivo studies.
Assessment of the key regulatory genes and their Interologs for Turner Syndrome employing network approach
Authors: Farooqui Anam , Tazyeen Safia , Ahmed Mohd. Murshad , Alam Aftab , Ali Shahnawaz , Malik Md. Zubbair , Ali Sher , Ishrat Romana
Published: June 2018

Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying the genes that regulate the TS network is one of the main challenges in understanding its aetiology. Here, we studied the regulatory network from manually curated genes reported in the literature and identified essential proteins involved in TS. The power-law distribution analysis showed that TS network carries scale-free hierarchical fractal attributes. This organization of the network maintained the self-ruled constitution of nodes at various levels without having centrality–lethality control systems. Out of twenty-seven genes culminating into leading hubs in the network, we identified two key regulators (KRs) i.e. KDM6A and BDNF. These KRs serve as the backbone for all the network activities. Removal of KRs does not cause its breakdown, rather a change in the topological properties was observed. Since essential proteins are evolutionarily conserved, the orthologs of selected interacting proteins in C. elegans, cat and macaque monkey (lower to higher level organisms) were identified. We deciphered three important interologs i.e. KDM6A-WDR5, KDM6A-ASH2L and WDR5-ASH2L that form a triangular motif. In conclusion, these KRs and identified interologs are expected to regulate the TS network signifying their biological importance.
Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies
Authors: Hart Marcia L. , Ericsson Aaron C. , Lloyd K. C. Kent , Grimsrud Kristin N. , Rogala Allison R. , Godfrey Virginia L. , Nielsen Judith N. , Franklin Craig L.
Published: June 2018

Studies indicate that the gut microbiota (GM) can significantly influence both local and systemic host physiologic processes. With rising concern for optimization of experimental reproducibility and translatability, it is essential to consider the GM in study design. However, GM profiles can vary between rodent producers making consistency between models challenging. To circumvent this, we developed outbred CD1 mouse colonies with stable, complex GM profiles that can be used as donors for a variety of GM transfer techniques including rederivation, co-housing, cross-foster, and fecal microbiota transfer (FMT). CD1 embryos were surgically transferred into CD1 or C57BL/6 surrogate dams that varied by GM composition and complexity to establish four separate mouse colonies harboring GM profiles representative of contemporary mouse producers. Using targeted 16S rRNA amplicon sequencing, subsequent female offspring were found to have similar GM profiles to surrogate dams. Furthermore, breeding colonies of CD1 mice with distinct GM profiles were maintained for nine generations, demonstrating GM stability within these colonies. To confirm GM stability, we shipped cohorts of these four colonies to collaborating institutions and found no significant variation in GM composition. These mice are an invaluable experimental resource that can be used to investigate GM effects on mouse model phenotype.
Interaction between hydrogen and gallium vacancies in β-Ga2O3
Authors: Wei Yidan , Li Xingji , Yang Jianqun , Liu Chaoming , Zhao Jinyu , Liu Yong , Dong Shangli
Published: June 2018

In this paper, the revised Heyd-Scuseria-Ernzerhof screened hybrid functional (HSE06) is used to investigate the interaction between hydrogen with different concentrations and gallium vacancies in β-Ga2O3. The hydrogen can compensate a gallium vacancy by forming hydrogen-vacancy complex. A gallium vacancy can bind up to four hydrogen atoms, and formation energies decrease as the number of hydrogen atoms increases. Hydrogen prefers to bind with three coordinated oxygen. The bonding energy and annealing temperatures of complexes containing more than two hydrogen atoms are computed, and show relatively high stability. In addition, vacancy concentrations increase with the increasing vapor pressures. This paper can effectively explain the hydrogen impact in β-Ga2O3.
Application of conicity index adjusted total body fat in young adults-a novel method to assess metabolic diseases risk
Authors: Zhang Yujie , Zeng Qiang , Li Xiaoying , Zhu Pengli , Huang Feng
Published: June 2018

The aim of the study was to evaluate the usefulness of conicity index (CI) adjusted total body fat (TBF), which was defined as TBF/CI, in various metabolic diseases in young adults. A cross-sectional study was carried out in Chinese PLA General Hospital and a total of 1365 young adults (age 20–40 years) who underwent a health check-up examination were finally included in the analysis from February 2016 to 2017. Linear Regression and logistic regression were used to further examine relationship between the index and metabolic diseases. The average age was 34.5 years. Odds Ratios (ORs) for the risk of metabolic diseases increased from the lowest to highest TBF/CI quartile (all P trends < 0.001). Young adults with increased TBF/CI had higher risk of hyperhomocysteinemia (Hhcy) (OR = 1.528, 95% confidence interval = 1.057–2.209). There was a 1.407 increase in the odds of obesity, a 1.112 increase in the odds of hyperlipidemia (HLP) and a 1.094 increase in the odds of diabetes mellitus (DM) per standard deviation (SD) increase in TBF/CI (all P < 0.001). TBF/CI showed higher predictive values for obesity, HLP, DM and Hhcy than weight adjusted total body fat (all P < 0.001). Young adults with increased TBF/CI had higher ratios of metabolic diseases, which suggested that TBF/CI can be a good indicator and had a close relationship with metabolic diseases.
Cold weather increases respiratory symptoms and functional disability especially among patients with asthma and allergic rhinitis
Authors: Hyrkäs-Palmu Henna , Ikäheimo Tiina M. , Laatikainen Tiina , Jousilahti Pekka , Jaakkola Maritta S. , Jaakkola Jouni J. K.
Published: June 2018

Cold weather affects the respiratory epithelium and induces bronchial hyperresponsiveness. We hypothesized that individuals with allergic rhinitis or/and asthma experience cold weather-related functional disability (FD) and exacerbation of health problems (EH) more commonly than individuals without these. This was a population-based study of 7330 adults aged 25–74 years. The determinants of interest, including doctor-diagnosed asthma and allergic rhinitis, and the outcomes, including cold weather-related FD and EH, were measured using a self-administered questionnaire. The prevalences of cold-related FD and EH were 20.3% and 10.3%, respectively. In Poisson regression, the risk of FD increased in relation to both allergic rhinitis (adjusted prevalence ratio (PR) 1.19, 95% CI 1.04–1.37 among men; 1.26, 95% CI 1.08–1.46 among women), asthma (1.29, 0.93–1.80; 1.36, 0.92–2.02, respectively) and their combination (1.16, 0.90–1.50; 1.40, 1.12–1.76, respectively). Also the risk of cold weather-related EH was related to both allergic rhinitis (1.53, 1.15,−2.04 among men; 1.78, 1.43–2.21 among women), asthma (4.28, 2.88–6.36; 3.77, 2.67–5.34, respectively) and their combination (4.02, 2.89–5.59; 4.60, 3.69–5.73, respectively). We provide new evidence that subjects with allergic rhinitis or/and asthma are more susceptible to cold weather-related FD and EH than those without pre-existing respiratory diseases.
Optimization of sample preparation and green color imaging using the mNeonGreen fluorescent protein in bacterial cells for photoactivated localization microscopy
Authors: Stockmar Iris , Feddersen Helge , Cramer Kimberly , Gruber Stephan , Jung Kirsten , Bramkamp Marc , Shin Jae Yen
Published: June 2018

mNeonGreen fluorescent protein is capable of photo-switching, hence in principle applicable for super-resolution imaging. However, difficult-to-control blinking kinetics that lead to simultaneous emission of multiple nearby mNeonGreen molecules impedes its use for PALM. Here, we determined the on- and off- switching rate and the influence of illumination power on the simultaneous emission. Increasing illumination power reduces the probability of simultaneous emission, but not enough to generate high quality PALM images. Therefore, we introduce a simple data post-processing step that uses temporal and spatial information of molecule localizations to further reduce artifacts arising from simultaneous emission of nearby emitters. We also systematically evaluated various sample preparation steps to establish an optimized protocol to preserve cellular morphology and fluorescence signal. In summary, we propose a workflow for super-resolution imaging with mNeonGreen based on optimization of sample preparation, data acquisition and simple post-acquisition data processing. Application of our protocol enabled us to resolve the expected double band of bacterial cell division protein DivIVA, and to visualize that the chromosome organization protein ParB organized into sub-clusters instead of the typically observed diffraction-limited foci. We expect that our workflow allows a broad use of mNeonGreen for super-resolution microscopy, which is so far difficult to achieve.
Discordance between self-report and clinical diagnosis of Internet gaming disorder in adolescents
Authors: Jeong Hyunsuk , Yim Hyeon Woo , Lee Seung-Yup , Lee Hae Kook , Potenza Marc N. , Kwon Jung-Hye , Koo Hoon Jung , Kweon Yong-Sil , Bhang Soo-young , Choi Jung-Seok
Published: June 2018

This study aimed to estimate overreporting (the false positive) and underreporting (false negative) rates in self-reported IGD assessment compared with clinical diagnosed IGD. The study population consisted of 45 with IGD and 228 without IGD based on clinical diagnosis from the Internet User Cohort for Unbiased Recognition of Gaming Disorder in Early Adolescence (iCURE) study. All participants completed self-reported IGD assessments. Clinical interviews were conducted blindly by trained mental health professionals based on DSM-5 IGD criteria. Self-assessed average daily amount of gaming time and game genre were measured. Psychological characteristics, including anxiety, suicidality, aggression, self-control, self-esteem, and family support, were obtained from the baseline survey. The false-negative rate for self-reported IGD assessment was 44%. The false-negative group reported less time playing online games than the IGD group, though their psychological characteristics were similar to those of the IGD group. The false-positive rate was 9.6%. They reported more time playing online games than non-IGD group, though their psychological characteristics were similar to those of non-IGD group except self-control. The discrepancy of IGD diagnoses between self-reports and clinical diagnosis revealed limitations of self-measurements. Various strategies are required to overcome the methodological shortfalls of self-reports for the assessment of IGD.
Floquet Weyl Magnons in Three-Dimensional Quantum Magnets
Authors: Owerre S. A.
Published: June 2018

In three-dimensional (3D) quantum magnets, magnonic Weyl points (WPs) featuring linear band crossing of two non-degenerate magnon branches can emerge in certain lattice geometry when time-reversal symmetry is broken macroscopically. Unfortunately, there are very limited 3D quantum magnets that host magnonic WPs, and they are yet to be observed experimentally because the intrinsic perturbative interactions that break time-reversal symmetry macroscopically can be very negligible. Here, we present an alternative means via photo-irradiation, in which magnonic WPs can emerge in 3D quantum magnets without relying on intrinsic perturbative interactions to break time-reversal symmetry. By utilizing the magnonic Floquet-Bloch theory, we put forward the general theory of magnonic Floquet WPs in 3D quantum magnets. We show that periodically driven 3D magnonic Dirac nodal-line (DNL) and 3D magnonic gapped trivial insulators can generate 3D magnonic Floquet WPs, which can be tuned by the incident circularly-polarized light. We demonstrate the existence of magnonic Floquet WPs by combining the study of the magnon dispersions, Berry curvatures, and the anomalous thermal Hall effect. The general theoretical formalism can be applied to different magnetic insulators, and thus extending the concept of magnonic WPs to a broader class of 3D magnetically ordered systems.
The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists
Authors: Johnson Rebecca H. , Kho Dan T. , O’ Carroll Simon J. , Angel Catherine E. , Graham E. Scott
Published: June 2018

Toll-Like receptors (TLRs) represent an important early warning mechanism for the immune system to detect infection or tissue damage. The focus of this research was to determine the neuroinflammatory responses to commercial TLR ligands and their effects on brain endothelial barrier strength. Using biosensor technology we screened TLR ligands to all human TLRs and found that the brain endothelial hCMVECs cell line only responded to Poly(I:C) (TLR3-ligand), LPS (TLR4-ligand) and Imiquimod (TLR7 ligand). Both Poly(I:C) and LPS induced pronounced pro-inflammatory cytokine secretion as expected, whereas Imiquimod did not induce secretion of any pro-inflammatory cytokines. Using ECIS technology to measure endothelial barrier function, LPS and Poly(I:C) both acutely reduced barrier-strength, whereas Imiquimod caused immediate and sustained strengthening of the barrier. Further cytokine and ECIS studies showed that Imiquimod could abrogate some of the pro-inflammatory responses to Poly(I:C) and LPS. Most surprisingly, PCR revealed that the hCMVECs lacked TLR7 but expressed both TLR3 and TLR4 and did not respond to other structurally different TLR7 ligands. These data demonstrate that brain endothelial cells can be regulated by TLR 3 and TLR4 ligands in a pro-inflammatory manner and have receptors to Imiquimod, distinct to the classical TLR7, that function in an anti-inflammatory manner.
Two-step breakdown of a SiN membrane for nanopore fabrication: Formation of thin portion and penetration
Authors: Yanagi Itaru , Hamamura Hirotaka , Akahori Rena , Takeda Ken-ichi
Published: June 2018

For the nanopore sensing of various large molecules, such as probe-labelled DNA and antigen-antibody complexes, the nanopore size has to be customized for each target molecule. The recently developed nanopore fabrication method utilizing dielectric breakdown of a membrane is simple and quite inexpensive, but it is somewhat unsuitable for the stable fabrication of a single large nanopore due to the risk of generating multiple nanopores. To overcome this bottleneck, we propose a new technique called “two-step breakdown” (TSB). In the first step of TSB, a local conductive thin portion (not a nanopore) is formed in the membrane by dielectric breakdown. In the second step, the created thin portion is penetrated by voltage pulses whose polarity is opposite to the polarity of the voltage used in the first step. By applying TSB to a 20-nm-thick SiN membrane, a single nanopore with a diameter of 21–26 nm could be fabricated with a high yield of 83%.
Objective evaluation of size and shape of superficial foveal avascular zone in normal subjects by optical coherence tomography angiography
Authors: Shiihara Hideki , Terasaki Hiroto , Sonoda Shozo , Kakiuchi Naoko , Shinohara Yuki , Tomita Masatoshi , Sakamoto Taiji
Published: June 2018

This study was conducted to investigate the size and shape of the foveal avascular zone (FAZ) determined by optical coherence tomography angiography (OCTA) and the relationship of the size and shape to the clinical findings in normal subjects. This was a cross-sectional study with seventy eyes of 70 volunteers. The size of the superficial FAZs were assessed by its area, length of perimeter, and Feret’s diameter, and the shape by the circularity, axial ratio, roundness, and solidity. The correlations between each parameter and the clinical findings were statistically determined. The coefficients of variation (CV) of the parameters of FAZ size were higher than that of the parameters of FAZ shape. The refractive error and axial length were significantly correlated with area-related factors. The central macular thickness (CMT) was significantly correlated with all parameters. Although the CMT was a critical factor that was significantly correlated with the size and shape characteristics of the FAZ, the shape might be a better factor for characterizing the FAZ than the size because of the low CV of shape-related factors and the characteristics are less affected by the other ocular factors.
A theory on skyrmion size
Authors: Wang X. S. , Yuan H. Y. , Wang X. R.
Published: June 2018

A magnetic skyrmion is a topological object consisting of a skyrmion core, an outer domain, and a wall that separates the skyrmion core from the outer domain. The skyrmion size and wall width are two fundamental quantities of a skyrmion that depend sensitively on material parameters such as exchange energy, magnetic anisotropy, Dzyaloshinskii–Moriya interaction, and magnetic field. However, quantitative understanding of the two quantities is still very poor. Here we present a general theory on skyrmion size and wall width. The two formulas we obtained agree almost perfectly with simulations and experiments for a wide range of parameters, including most of the existing materials that support skyrmions.
Correction: Corrigendum: Quantifying the cooperative subunit action in a multimeric membrane receptor
Authors: Wongsamitkul Nisa , Nache Vasilica , Eick Thomas , Hummert Sabine , Schulz Eckhard , Schmauder Ralf , Schirmeyer Jana , Zimmer Thomas , Benndorf Klaus
Published: June 2018

Scientific Reports 6; Article number: 20974; published online: 09 February 2016; updated: 28 June 2018 The Acknowledgements section in this Article is incomplete. “We would like to thank G. Ditze, G. Sammler, F. Horn, M. Händel, K. Schoknecht, S. Bernhardt, and A. Kolchmeier for technical assistance. This work was supported by grants of the Deutsche Forschungsgemeinschaft to K.
Correction: Noncompetitive homogeneous immunodetection of small molecules based on beta-glucuronidase complementation
Authors: Su Jiulong , Dong Jinhua , Kitaguchi Tetsuya , Ohmuro-Matsuyama Yuki , Ueda Hiroshi
Published: June 2018

Correction for ‘Noncompetitive homogeneous immunodetection of small molecules based on beta-glucuronidase complementation’ by Jiulong Su et al., Analyst, 2018, 143, 2096–2101.
Protein-protected red emittive copper nanoclusters as a fluorometric probe for highly sensitive biosensing of creatinine
Authors: Rajamanikandan Ramar , Ilanchelian Malaichamy
Published: June 2018

We describe red emittive bovine serum albumin-modified copper nanoclusters (BSA-CuNCs) applied as a precise fluorescent nanoprobe for the optical recognition of creatinine in human urine samples.
One-pot preparation of wavy graphene/Au composites and their application for highly sensitive detection of nitrite
Authors: He Bao-Shan , Yan Dan-Dan
Published: June 2018

The detection of nitrite is vital for environmental conservation and public health.
Biomimetic tumor microenvironments based on collagen matrices
Authors: Sapudom Jiranuwat , Pompe Tilo
Published: June 2018

This review provides an overview of the current approaches to engineer defined 3D matrices for the investigation of tumor cell behaviorin vitro, with a focus on collagen-based fibrillar systems.
Surface-initiated atom transfer radical polymerization of cationic corona on iron oxide nanoparticles for magnetic sorting of macrophages
Authors: Kang Myun Koo , Mao Wei , Yoo Hyuk Sang
Published: June 2018

Magnetic sorting of macrophages by ovalbumin-incorporated iron oxide nanoparticles.
Directed ortho C–H borylation catalyzed using Cp*Rh(iii)–NHC complexes
Authors: Thongpaen Jompol , E. Schmid Thibault , Toupet Loic , Dorcet Vincent , Mauduit Marc , Baslé Olivier
Published: June 2018

Cp*Rh(NHC) complexes with bulky chiral bidentate NHC-carboxylate ligands demonstrated high selectivity in the pyridine-directed C–H borylation of arenes under mild conditions.
A lithium ion/oxygen hybrid battery with high energy and high power
Authors: Mu Shijia , Zhu Ding , Zhang Ruixue , Zhang Kaifang , Ding Zhendong , Chen Yungui
Published: June 2018

A high-energy and high-power lithium ion/oxygen hybrid battery system.
Transpeptidation-directed intramolecular bipartite tetracysteine display for sortase activity assay
Authors: Xu Ai-jun , Yang Yong , Zhang Chun-Yang
Published: June 2018

We developed a simple, label-free and homogenous assay to quantitively evaluate SrtA-catalyzed transpeptidation reaction.
Nanotube-shaped PtFe intermetallics: controlled synthesis, crystal structure, and improved electrocatalytic activities
Authors: Zhang Xuebin , Tian Shujun , Yu Wenjing , Lu Bingqing , Shen Tianyang , Xu Lin , Sun Dongmei , Zhang Shoulin , Tang Yawen
Published: June 2018

Nanotube-shaped PtFe intermetallics synthesized over charged β-FeOOH by self-assembly and careful heat treatment exhibit higher Pt activities toward methanol electro-oxidation.
Molecular dynamics simulations of ammonium/phosphonium-based protic ionic liquids: influence of alkyl to aryl group
Authors: Mondal Anirban , Sunda Anurag Prakash
Published: June 2018

The variation of the center atom in the cation from an N to a P-atom leads to improved physiochemical properties of protic ionic liquids (PILs) which are suitable for electrolyte applications.
New two-dimensional porous graphitic carbon nitride nanosheets for highly efficient photocatalytic hydrogen evolution under visible-light irradiation
Authors: Zhang Longshuai , Ding Ning , Wu Jionghua , Iwasaki Kodai , Lin Lihua , Yamaguchi Yuichi , Shibayama Yuko , Shi Jiangjian , Wu Huijue , Luo Yanhong , Nakata Kazuya , Li Dongmei , Wang Xinchen , Fujishima Akira , Meng Qingbo
Published: June 2018

A one-step thermopolymerization method based on a supramolecular precursor has been developed for preparing 2D porous graphitic carbon nitride.
CsPbBr3 perovskite quantum dots/ZnO inverse opal electrodes: photoelectrochemical sensing for dihydronicotinamide adenine dinucleotide under visible irradiation
Authors: Zhu Yongsheng , Tong Xinling , Song Haizhen , Wang Yinhua , Qiao Zhanping , Qiu Dongfang , Huang Jinshu , Lu Zhiwen
Published: June 2018

All-inorganic perovskite quantum dots (PQDs) have attracted tremendous attention due to their extraordinary optical properties, especially CsPbBr3 QDs with their high stability and photoluminescence efficiency.
Hysteretic spin crossover in isomeric iron(ii) complexes
Authors: Bushuev Mark B. , Krivopalov Viktor P. , Nikolaenkova Elena B. , Vinogradova Katerina A. , Gatilov Yuri V.
Published: June 2018

Iron(ii) complexes with isomeric N,N,N-tridentate pyrimidine-based ligands demonstrate spin crossover with wide thermal hysteresis.
On the gas-phase formation of the HCO− anion: accurate quantum study of the H− + CO radiative association and HCO radiative electron attachment
Authors: Stoecklin Thierry , Halvick Philippe , Lara-Moreno Miguel , Trabelsi Tarek , Hochlaf Majdi
Published: June 2018

Here, we present the first study of the radiative association of H− and CO to form the HCO− anion within a quantum time-independent approach..
Hydrofunctionalization of olefins to value-added chemicals via photocatalytic coupling
Authors: Fan Yonghui , Li Shenggang , Bao Jingxian , Shi Lei , Yang Yanzhang , Yu Fei , Gao Peng , Wang Hui , Zhong Liangshu , Sun Yuhan
Published: June 2018

A sustainable strategy for the hydrofunctionalization of olefins to value-added chemicals via photocatalytic cross-coupling was developed with high atomic economy.
Enhancement of radionuclide bio-decontamination by screening highly efficient microalgae for Sr biomineralization
Authors: Wang Cong , Lee Keon Ah , Choi Eunpyo , Lee Keun-Young , Lee Seung-Yop , Jung Kwang-Hwan , Park Jungyul
Published: June 2018

In this study, a new strategy for improving the radionuclide bio-decontamination (RBD) activity of microalgae by screening a better strain with high potential for biomineral production has been proposed.
Organophosphoric acid-derived CoP quantum dots@S,N-codoped graphite carbon as a trifunctional electrocatalyst for overall water splitting and Zn–air batteries
Authors: Meng Tao , Hao Yi-Ning , Zheng Lirong , Cao Minhua
Published: June 2018

CoP@SNC prepared by using organophosphoric acid can be used as a trifunctional catalyst for overall water splitting and Zn–air batteries.
Asymmetric organocatalytic synthesis of chiral 3,3-disubstituted oxindolesviaa 1,6-conjugate addition reaction
Authors: Rahman Abdul , Zhou Qiaoxia , Lin Xufeng
Published: June 2018

The chiral spirocyclic phosphoric acid-catalyzed enantioselective 1,6-conjugate addition reaction ofpara-quinone methides derived fromN-unprotected isatins with indoles was developed.
Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature
Authors: Singh Adesh Kumar , Kandasamy Jeyakumar
Published: June 2018

A wide range of glycals underwent C-arylation with aryldiazonium tetrafluoroborates and provided synthetically useful 2,3-deoxy 3-keto α-aryl-C-glycosides in good to excellent yields.
First-principles investigations of manganese oxide (MnOx) complex-sandwiched bilayer graphene systems
Authors: Muhammad Rafique , Shuai Yong , Irfan Ahmed , He-Ping Tan
Published: June 2018

We calculate the physical parameters of MnOx (x = 0–4), cluster-sandwiched bilayer graphene (BLG) systems, utilizing first-principles calculations with van der Waals corrections implemented (DFT).
Porous three-dimensional network of Pd–Cu aerogel toward formic acid oxidation
Authors: Douk Abdollatif Shafaei , Farsadrooh Majid , Damanigol Farzane , Moghaddam Alireza Ansari , Saravani Hamideh , Noroozifar Meissam
Published: June 2018

New self-assembled architectures have received great interest in nanotechnology, and are a highly desired target in recent studies.
Nucleobase deaminases: a potential enzyme system for new therapies
Authors: Gaded Vandana , Anand Ruchi
Published: June 2018

This review presents an overview of the structure, function and mechanism of CDA deaminases and their potential as enzyme systems for development of new antimicrobial therapies.
The utilization of a stable 2D bilayer MOF for simultaneous study of luminescent and photocatalytic properties: experimental studies and theoretical analysis
Authors: Wu Xiren , Shen Xin , Fan Shuran , Trivedi Manoj , Li Boahong , Kumar Abhinav , Liu Jianqiang
Published: June 2018

A new 2D stable Pb(ii)-based MOF has been synthesized and used as dual channel sensor for the detection of ferric ions and nitroaromatics as well as the photocatalyst for the degradation of dyes.
Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis
Authors: Espinoza-Cara Andrés , Zitare Ulises , Alvarez-Paggi Damián , Klinke Sebastián , Otero Lisandro H. , Murgida Daniel H. , Vila Alejandro J.
Published: June 2018

Loop directed mutagenesis leads to a cupredoxin withthe strongest copper–thiolate bond known to date, high reduction potential and imidazole binding properties.
Ring-opening hydroarylation of monosubstituted cyclopropanes enabled by hexafluoroisopropanol
Authors: Richmond Edward , Yi Jing , Vuković Vuk D. , Sajadi Fatima , Rowley Christopher N. , Moran Joseph
Published: June 2018

Ring-opening hydroarylation of cyclopropanes is typically limited to substrates bearing a donor–acceptor motif. Here, the transformation is achieved for monosubstituted cyclopropanes by using catalytic Brønsted acid in hexafluoroisopropanol (HFIP) solvent.
Highly luminescent phosphine oxide-containing bipolar alkynylgold(iii) complexes for solution-processable organic light-emitting devices with small efficiency roll-offs
Authors: Lee Chin-Ho , Tang Man-Chung , Cheung Wai-Lung , Lai Shiu-Lun , Chan Mei-Yee , Yam Vivian Wing-Wah
Published: June 2018

Phosphine oxide-containing alkynylgold(iii) complexes were synthesized and fabricated into solution-processable OLEDs with high EQEs and small efficiency roll-offs.
Characterising knotting properties of polymers in nanochannels
Authors: Beaton N. R. , Eng J. W. , Ishihara K. , Shimokawa K. , Soteros C. E.
Published: June 2018

Theoretical and numerical evidence suggests that knotted polymers at equilibrium in nanochannels tend to favour the top shape.
Determining the importance of the electrode support and fabrication method during the initial screening process of an active catalyst for the oxygen evolution reaction
Authors: Browne Michelle P. , Mills Andrew
Published: June 2018

This work aims to illustrate the importance of selecting the best substrate and ‘powder to electrodes’ when screening new OER catalysts.
A heterojunction strategy to improve the visible light sensitive water splitting performance of photocatalytic materials
Authors: Afroz Khurshida , Moniruddin Md , Bakranov Nurlan , Kudaibergenov Sarkyt , Nuraje Nurxat
Published: June 2018

This article summarizes the photocatalytic water splitting performance improvement with a heterojunction system.
A self-powered triboelectric microfluidic system for liquid sensing
Authors: Kim Wook , Choi Daehwan , Kwon Jang-Yeon , Choi Dukhyun
Published: June 2018

Self-powered triboelectric microfluidic system was developed for the simple and rapid liquid sensing with multiple methods such as triboelectric signal and resistance measurement.
Improved light harvesting efficiency of semitransparent organic solar cells enabled by broadband/omnidirectional subwavelength antireflective architectures
Authors: Dudem Bhaskar , Jung Jae Woong , Yu Jae Su
Published: June 2018

A subwavelength antireflection layer significantly improves not only transmittance and color perception but also the efficiency of transparent solar cells.
Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases
Authors: Wu Yuao , Yang Yanchen , Zhao Wei , Xu Zhi Ping , Little Peter J. , Whittaker Andrew K. , Zhang Run , Ta Hang T.
Published: June 2018

Novel iron oxide–cerium oxide core–shell theranostic nanoparticles for MRI and ROS scavenging effects.
Multiple microarrays of non-adherent cells on a single 3D stimuli-responsive binary polymer-brush pattern
Authors: Hou Jianwen , Chen Runhai , Liu Jingchuan , Wang Haozheng , Shi Qiang , Xin Zhirong , Wong Shing-Chung , Yin Jinghua
Published: June 2018

A hierarchically binary PGAMA/PNIPAM pattern is fabricated, and multiple cell microarrays are formed on this single pattern with the aid of Con A and temperature.
Correction: Mitochondrial dysfunction-induced apoptosis in breast carcinoma cells through a pH-dependent intracellular quercetin NDDS of PVPylated-TiO2NPs
Authors: Ponraj Thondhi , Vivek Raju , Paulpandi Manickam , Rejeeth Chandrababu , Babu Varukattu Nipun , Vimala Karuppaiya , Anand Krishnan , Sivaselvam Subramani , Vasanthakumar Alagarsamy , Ponpandian Nagamony , Kannan Soundarapandian
Published: June 2018

Correction for ‘Mitochondrial dysfunction-induced apoptosis in breast carcinoma cells through a pH-dependent intracellular quercetin NDDS of PVPylated-TiO2NPs’ by Thondhi Ponraj et al., J. Mater. Chem. B, 2018, 6, 3555–3570.
Enhanced sensing performance of carboxyl graphene–ionic liquid attached ionic polymer–metal nanocomposite based polymer strain sensors
Authors: Panwar Varij , Anoop Gopinathan
Published: June 2018

Here, we show that biocompatible IPMNC sensors based on a carboxyl graphene–acidic ionic liquid–polyvinylpyrrolidone–polystyrene sulfonic acid ionic blend membrane can generate a high sensing current (6 mA cm−2) with a bending strain of 0.009.
Less toxic zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine N,N-dimethylthiosemicarbazone: synthesis, crystal structures, cytotoxicity and investigations of mechanisms of action
Authors: Fang Yan , Li Jie , Han Pei-Pei , Han Qiu-Xia , Li Ming-Xue
Published: June 2018

Growth inhibition results showed that 1 exhibited toxicity on QSG7701 cells which was 12-fold lower than that of HepG2 cells.
SGLT2 inhibition and kidney protection
Authors: Nespoux Josselin , Vallon Volker
Published: June 2018

Type 2 diabetes mellitus (T2DM) is a growing public health concern worldwide. Numerous drug classes are available for treatment, however, their efficacy with regard to diabetes-induced renal and cardiovascular (CV) complications remains limited. Inhibitors of the sodium-glucose cotransporter 2 (SGLT2) are a new class of blood glucose lowering medications that block renal glucose reabsorption and have protective effects on the kidney and the heart. This review focusses on the effects of SGLT2 inhibitors on the kidney and renal outcome: it briefly outlines renal glucose handling in diabetes and its role in glomerular hyperfiltration and renal hypoxia; describes how SGLT2 inhibitors induce an early, reversible reduction in glomerular filtration rate (GFR) and preserve GFR in the long-term in patients with T2DM; discusses whether the enhanced active transport in the renal outer medulla (OM) in response to SGLT2 inhibition is friend or foe; proposes how the blood pressure lowering and heart failure protective effect of SGLT2 inhibitors can be preserved in chronic kidney disease (CKD) despite attenuated antihyperglycemic effects; and examines whether SGLT2 inhibition enhances the incidence or severity of acute kidney injury (AKI).
A comparison of the local spiral structure from Gaia DR2 and VLBI maser parallaxes
Authors: Xu Y. , Bian S. B. , Reid M. J. , Li J. J. , Zhang B. , Yan Q. Z. , Dame T. M. , Menten K. M. , He Z. H. , Liao S. L. , Tang Z. H.
Published: June 2018

Context. The Gaia mission has released the second data set (Gaia DR2), which contains parallaxes and proper motions for a large number of massive, young stars.

Aims. We investigate the spiral structure in the solar neighborhood revealed by Gaia DR2 and compare it with that depicted by VLBI maser parallaxes.

Methods. We examined three samples with different constraints on parallax uncertainty and distance errors and stellar spectral types: (1) all OB stars with parallax errors of less than 10%; (2) only O-type stars with 0.1 mas errors imposed and with parallax distance errors of less than 0.2 kpc; and (3) only O-type stars with 0.05 mas errors imposed and with parallax distance errors of less than 0.3 kpc.

Results. In spite of the significant distance uncertainties for stars in DR2 beyond 1.4 kpc, the spiral structure in the solar neighborhood demonstrated by Gaia agrees well with that illustrated by VLBI maser results. The O-type stars available from DR2 extend the spiral arm models determined from VLBI maser parallaxes into the fourth Galactic quadrant, and suggest the existence of a new spur between the Local and Sagittarius arms.
On convergent schemes for two-phase flow of dilute polymeric solutions
Authors: Metzger Stefan
Published: June 2018

We construct a Galerkin finite element method for the numerical approximation of weak solutions to a recent micro-macro bead-spring model for two-phase flow of dilute polymeric solutions derived by methods from nonequilibrium thermodynamics ([Grün, Metzger, M3AS 26 (2016) 823–866]). The model consists of Cahn-Hilliard type equations describing the evolution of the fluids and the unsteady incompressible Navier-Stokes equations in a bounded domain in two or three spatial dimensions for the velocity and the pressure of the fluids with an elastic extra-stress tensor on the right-hand side in the momentum equation which originates from the presence of dissolved polymer chains. The polymers are modeled by dumbbells subjected to a finitely extensible, nonlinear elastic (FENE) spring-force potential. Their density and orientation are described by a Fokker-Planck type parabolic equation with a center-of-mass diffusion term. We perform a rigorous passage to the limit as the spatial and temporal discretization parameters simultaneously tend to zero, and show that a subsequence of these finite element approximations converges towards a weak solution of the coupled Cahn-Hilliard-Navier-Stokes-Fokker-Planck system. To underline the practicality of the presented scheme, we provide simulations of oscillating dilute polymeric droplets and compare their oscillatory behaviour to the one of Newtonian droplets.
Coenzym Q10 – der mitochondriale Blockbuster
Authors: Gröber Uwe
Published: June 2018

Coenzym Q10 (Ubiquinon) spielt eine zentrale Rolle bei der Energiegewinnung in den Mitochondrien. Der mitotrope Mikronährstoff zeigte in einer Studie synergistische Wirkung mit Selen bei der Reduktion der kardiovaskulären Mortalität. Coenzym Q10 hat sowohl antioxidative als auch prooxidative, für multiple physiologische Funktionen des Metaboloms essenzielle, Wirkung. Sein Blutspiegel ist bei Erkrankungen mit oxidativem Stress häufig erniedrigt. Coenzym Q10 und seine besser bioverfügbare reduzierte Form Ubiquinol haben sich in Prävention und Therapie zahlreicher Erkrankungen bewährt.
Postural Adjustments Following ACL Rupture and Reconstruction: A Longitudinal Study
Authors: Labanca Luciana , Laudani Luca , Mariani Pier , Macaluso Andrea
Published: June 2018

Longitudinal changes in compensatory and anticipatory postural adjustments around the knee were investigated from rupture of ACL until return to play after reconstruction. Twelve ACL-injured participants (ACL-P) were asked to respond to unpredictable and predictable perturbations before (T1), 2 (T2) and 6 months after (T3) reconstruction. Twelve healthy participants served as controls. Compensatory and anticipatory latencies of vastus lateralis (VL) and medialis (VM) were measured with respect to the arrival of perturbations. ACL-P showed delayed compensatory latencies compared to controls at T1 for VL (101±32 ms vs 63±7 ms) and VM (117±36 ms vs 75±17 ms) and at T2 for VL (94±20 ms vs 63±7 ms) and VM (94±27 ms vs 71±11 ms). ACL-P showed earlier anticipatory latencies than controls for VL at T1 (-69±44 ms vs -12±12 ms) and T2 (-46±17 ms vs -16±12 ms). At T3, ACL-P showed delayed compensatory latencies for VL (91±18 ms vs 56±21 ms) and VM (95±13 ms vs 66±4 ms), whilst anticipatory latencies were restored. Rehabilitation should address delayed compensatory responses.
Metformin and Colorectal Cancer – A Systematic Review.
Authors: Kobiela Jarek , Dobrzycka Małgorzata , Jędrusik Piotr , Kobiela Paulina , Spychalski Piotr , Śledziński Zbigniew , Zdrojewski Tomasz
Published: June 2018

Objectives Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. The development of preventive strategies in CRC has been the subject of much research. Multiple studies have shown an association between diabetes and CRC. In addition to its glucose-lowering properties, metformin might have an additional role in the prevention and treatment of CRC.

Our objective was to summarize findings on role of metformin in colorectal cancer.

Methods We conducted a systematic review of the PubMed and Cochrane databases from January 2005 to December 2017 in search for studies on the association between metformin and CRC.

Results Of the total of 189 studies identified by the search, we excluded 123 studies and reviewed the remaining 66 studies on cell lines, animals, patients with diabetes, and healthy subjects. In vitro and animal studies have shown a protective effect of metformin use on the incidence of CRC and amplification of the therapeutic effects of CRC chemotherapy. Studies on patients with type 2 diabetes treated with metformin analyzed data on total of 146 496 patients. The results of those studies on the role of metformin in CRC suggest risk reduction and potential applications within therapeutic regimens, although some of those are conflicting.

Conclusion Further studies are warranted to define the role of metformin in both prevention and treatment of CRC.
Enantioselective Arylation of Oxindoles Using Modified BI-DIME Ligands
Authors: Haddad Nizar , Senanayake Chris , Mangunuru Hari , Malapit Christian , Reeves Jonathan , Qu Bo , Rodriguez Sonia , Lee Heewon , Yee Nathan , Song Jinhua , Busacca Carl
Published: June 2018

The Pd-catalyzed 3-arylation of 2-oxindoles with aryl bromides, chlorides and triflates is found to proceed using i-Pr-BI-DIME and Me2-BI-DIME ligands. The mono-arylation of 3-unsubstituted oxindoles is accomplished using a Pd2(dba)3/i-Pr-BI-DIME catalyst system, and gives good yields of 3-aryloxindoles from aryl bromides and chlorides. The arylation of 3-substituted oxindoles is also possible using this catalyst/ligand system. The asymmetric arylation of 3-substituted oxindoles is accomplished using Me2-BI-DIME to furnish oxindoles bearing a quaternary C-3 stereocenter in enantiomeric ratios of up to 93:7.
Copper-Catalyzed C–N Bond Formation via C–H Functionalization: Facile Synthesis of Multisubstituted Imidazo[1,2-a]pyridines from N-(2-Pyridinyl)enaminones
Authors: Iazzetti Antonia , Cacchi Sandro , Ciogli Alessia , Demitri Nicola , Fabrizi Giancarlo , Ghirga Francesca , Goggiamani Antonella , Lamba Doriano
Published: June 2018

An efficient, new copper-catalyzed approach to the construction of the multisubstituted imidazo[1,2-a]pyridine skeleton from N-(2-pyridinyl)enaminones has been developed.
Recent Developments on N-Heterocyclic Carbene Supported Zinc Complexes: Synthesis and Use in Catalysis
Authors: Dagorne Samuel
Published: June 2018

The present contribution reviews the synthesis, reactivity, and use in catalysis of NHC–Zn complexes reported since 2013. NHC-stabilized Zn(II) species typically display enhanced stability relative to common organozinc species (such as Zn dialkyls), a feature of interest for the mediation of various chemical processes and the stabilization of reactive Zn-based species. Their use in catalysis is essentially dominated by reduction reactions of various unsaturated small molecules (including CO2), thus primarily involving Zn–H and Zn–alkyl derivatives as catalysts. Simple NHC adducts of Zn(II) dihalides also appear as effective catalysts for the reduction amination of CO2 and borylation of alkyl/aryl halides. Stable and well-defined Zn alkoxides have also been prepared and behave as effective catalysts in the polymerization of cyclic esters/carbonates for the production of well-defined biodegradable materials. Overall, the attractive features of NHC-based Zn(II) species include ready access, a reasonable stability/reactivity balance, and steric/electronic tunability (through the NHC source), which should promote their further development.

1 Introduction

2 NHC-Supported Zinc Alkyl/Aryl Species

2.1 Synthesis

2.2 Reactivity and Use in Catalysis

3 NHC-Supported Zinc Hydride Species

3.1 Synthesis

3.2 Reactivity and Use in Catalysis

4 NHC-Supported Zinc Amido/Alkoxide Species

4.1 Synthesis

4.2 Use in Catalysis

5 NHC-Supported Zinc Dihalide Species

5.1 Synthesis

5.2 Use in Catalysis

6 Other NHC-Stabilized Zn Species

7 Conclusion
Reevaluation of the Palladium/Carbon-Catalyzed Decarbonylation of Aliphatic Aldehydes
Authors: Opsenica Igor , Ajdačić Vladimir , Nikolić Andrea , Kerner Michael , Wipf Peter
Published: June 2018

An improved method for the decarbonylation of aliphatic ­aldehydes by using a commercially available Pd/C catalyst is described. The reaction conditions are suitable for linear, cyclic, or sterically demanding substrates, as they afford the corresponding alkanes in yields of up to 99%. In addition, this Pd/C-catalyzed method exhibits good functional-group tolerance. A comparison of previously reported methods with the present one showed that the reaction conditions play a crucial role in the outcome of the reaction. The method can also be ­applied in a two-step reaction sequence for the synthesis of industrially important compounds.