bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Phenolic Content, Anti-oxidant and modulation of blood indices of Pavetta crassipes
Authors: Esievo Kevwe Benefit , Gegele Ibrahim Babatunde , Aliyu Adamu , Fidelis Solomon Ameh , Fatokun Omolola Temitope , Ibrahim Jemilat Aliyu
Published: July 2023

IntroductionPavetta crassipes is a medicinal plant with various documented biological activities. It has a folkloric use as an anti-viral therapy and pharmacologically documented anti-microbial activity. However, its immune modulatory property has not been explored. The study is designed to evaluate the phytochemical profile as well as the anti-oxidant and immunomodulatory potential of the methanol extract of Pavetta crassipes leaf.
Methodology In vitro antioxidants activity was determined by nitric oxide inhibitory assay. phenolic and flavonoid content of the extract was also determined. The immunomodulatory activity was evaluated using cyclophosphamide induced immunomodulation model in mice. Phytochemical evaluation of leaf extract was done using HPLC analyses. Results were expressed as the mean ± SEM, IC50 value for the antioxidant activity was determined, One-way ANOVA was used for differences in mean followed by Dunnett’s test for multiple comparison for the immunomodulatory activity. To test for level of significance, P< 0.05 was considered significant.
ResultsThe extract had phenolic and flavonoid contents of 17.6 ±0.1 mg/GAE/g and 8.4 ± 0.3 mg/QE/g respectively. The extract also showed nitric oxide inhibitory antioxidant activity with IC50 of 2.3± 0.4 while gallic and ascorbic acid had IC50 of 1.6 ±0.1 and 8.0 ±0.6 respectively. P. crassipes leaf extract indicated a significant (p<0.05) countering influence to cyclophosphamide induced decrease in total white blood count, differential leucocyte counts and red blood count. HPLC analysis indicated the presence of phenolic compounds such a rutin, quercetin and chlorogenic acid.
ConclusionThe phytochemical profile, anti-oxidant and immunomodulatory properties of the methanol extract of P. crassipes leaf as evaluated in this study corroborates and justifies its folkloric use.
Current scenario of climate change and its impact on plant diseases
Authors: Kaur Gurpreet , Singh Harjot , Maurya Shivam , Kumar Chandan , Kumar Adesh
Published: July 2023

The change in global climate is because of expanding convergence of greenhouse gases (GHG) in the environment. Climate changes observed on Earth in recent years are mostly the result of various human activities. The global temperature has risen by around 0.8 °C over the past hundred years and is expected to ascend by between 0.9 and 3.5 °C by 2100. Climate change does not only affect the holistic crop growth but also influence the spread, multiplication, incidence and severity of many phytopathogenic agents. These effects will be seen not only on the other elements of the agroecosystem but also on plants and other organisms. Climate change involving rise in temperature and CO2 level in the atmosphere, and other weather events such as drought and flooding, all affects the host plant resistance to pathogens. Climate change has the potential to alter host-pathogen interactions and ultimately pose great impact on development of disease epidemics. However, determining these effects is difficult, so experts from various fields must look beyond their own disciplinary boundaries and put the effects of climate change in a larger context. Various plant disease models have been created to integrate modern climate forecasts at different levels. According to climate change scenario, there is great need to modify the methods of disease management in terms of their geographic and temporal distribution. This review uses appropriate examples to demonstrate the many implications that climate change has on plant diseases and their repercussions.
Postawy wobec prawa i poglądy polityczne studentów Wydziału Prawa i Administracji Uniwersytetu im. Adama Mickiewicza w Poznaniu
Authors: Gronowski Marcin , Plewa Emil
Published: July 2023

Niniejszy tekst stanowi sprawozdanie z badań ankietowych przeprowadzonych na grupie studentów Wydziału Prawa i Administracji Uniwersytetu im. Adama Mickiewicza w Poznaniu w grudniu 2022 r. Autorzy chcieli uzyskać odpowiedzi na pytania dotyczące postaw wobec prawa oraz poglądów politycznych studentów Wydziału Prawa i Administracji Uniwersytetu im. Adama Mickiewicza w Poznaniu. W badaniach posłużono się anonimowym, jednorazowym, audytoryjnym, nadzorowanym kwestionariuszem ankietowym z pytaniami zamkniętymi.
Spory sądowe z zakresu prawa pracy w świetle akt zarządu przymusowego na dobrach fideikomisu pszczyńskiego (1934–1939)
Authors: Kucharski Tomasz
Published: July 2023

Artykuł poświęcony jest problematyce prawa pracy w Polsce międzywojennej w latach 30. XX wieku. Autor dokonuje analizy akt autentycznych sporów sądowych metodą case study. Badania zostały oparte na dokumentacji ponad czterdziestu spraw, przechowywanych w zbiorach Archiwum Państwowego w Katowicach, Oddział w Pszczynie. Autor uzyskał te akta nie z zespołów akt sądów, ale ze zbiorów odrębnego zespołu zawierającego dokumentację z zachowanego rodzinno-majątkowego archiwum fideikomisu Hochbergów w Pszczynie. Zespół ten oferuje niemal 300 zachowanych akt spraw cywilnych z lat 1934-1939 (kiedy na podstawie przepisów kodeksu procedury cywilnej na dobrach ziemskich i fabrykach fideikomisu był ustanowiony zarząd przymusowy). Artykuł wykazuje, jak wartościowe są zbiory pozostałe po archiwach rodzin arystokratycznych dla rekonstruowania utraconych akt międzywojennego wymiaru sprawiedliwości. Analiza obejmuje szeroki zakres zagadnień: bezprawne zwalnianie pracowników, zatrzymywanie wynagrodzeń pracowników oraz potrącanie wierzytelności pracodawców z tych wynagrodzeń bez podstawy prawnej, specyfika zatrudniania pracowników umysłowych oraz wady oświadczeń woli w zakresie umów o pracę. Pozwala to ukazać stan rozwoju prawa pracy w latach 30. XX wieku i ocenić skomplikowaną sytuację ekonomiczną największych fideikomisów familijnych w międzywojennej Polsce.
Znaczenie przywileju koszyckiego z 1374 roku wobec rozważań o prawach kobiet w Polsce
Authors: Lisiecka Julia
Published: July 2023

Problematyka artykułu dotyczy niedostrzeganego dotąd przez badaczy historii aspektu przywileju koszyckiego z 1374 r. Oprócz niewątpliwego znaczenia tego aktu dla rozwoju demokracji szlacheckiej miał on także znaczenie jako pierwszy akt prawny na ziemiach polskich traktujący o prawach kobiet. Nadanie przywileju z 1374 r. przedstawiono w kontekście dziejowym przez ujęcie tego zdarzenia prawnego na tle sytuacji na ziemiach polskich w XIV wieku, uwzględniając zagadnienia historyczne, polityczne, społeczne i kulturowe. Ukazano również sytuację prawno-społeczną kobiet. Scharakteryzowano postanowienia przywileju koszyckiego, z uwzględnieniem celu jego nadania, tj. zagwarantowania córkom Ludwika I Wielkiego sukcesji tronu polskiego, oraz omówiono jego następstwa.
Przedstawiono nadanie przywileju z 1374 roku w kontekście dziejowym poprzez uplasowanie tego zdarzenia prawnego na tle sytuacji na ziemiach polskich w XIV wieku, uwzględniając zagadnienia historyczne, polityczne, społeczne oraz kulturowe. Wskazano również na sytuację prawno – społeczną kobiet. Scharakteryzowano postanowienia przywileju koszyckiego, ze szczególnym uwzględnieniem celu jego nadania, tj. zagwarantowania córkom Ludwika I Wielkiego sukcesji tronu polskiego oraz wskazano na jego następstwa.
Pojęcie wartości w orzecznictwie sądów administracyjnych
Authors: Plewa Emil
Published: July 2023

Sądy administracyjne w uzasadnieniach orzeczeń posługują się terminem „wartość”. Pojęcie to już w sferze języka naturalnego ma co najmniej cztery znaczenia. W języku prawniczym stosowanym w orzecznictwie przybrało nowe znaczenia na użytek praktyki sądowej. Celem artykułu jest przedstawienie wyników analizy orzecznictwa sądów administracyjnych pod kątem używania terminu „wartość” oraz przypisywanych mu znaczeń. Autor przedstawia słownikowe definicje omawianego terminu, jego aspekty teoretycznoprawne, tj. relacje wartości-oceny, wartości-zasady, oraz cztery znaczenia terminu „wartość” używane w orzecznictwie sądów administracyjnych, tj. wartość w sensie ekonomicznym, wartość w odwołaniu do innych systemów ocen (poza ekonomicznym), wartość dowodowa, wartość w sensie odnoszącym się do systemu ocen prawodawcy. Wnioski dotyczą aksjologicznej warstwy uzasadnień orzecznictwa i powoływania się przez sądy administracyjne w orzecznictwie na wartości przypisywane prawodawcy.
Lech Majewski, metafizyka i Bosch
Authors: Wysłouch Seweryna
Published: July 2023

The subject of the analysis is the problem of metaphysics in Lech Majewski’s novel Metafizyka [Metaphysics] (2002) and in the author’s film adaptation entitled Ogród rozkoszy ziemskich [The  Garden of Earthly Delights] (2004). In the novel, metaphysical sensations are conveyed through discourse: 1) the reflections of the rationalist protagonist who undergoes a crisis of worldview following the death of his partner, and 2) in interpretations of the mysterious triptych by Hieronymus Bosch, showing an irreal world: an earthly paradise which the characters attempt to emulate by repeating scenes from the painting. In the film, Majewski aban metaphysical discourse in favour of exposing The Garden of Earthly Delights and showing elaborate psychological portraits of his characters, especially the heroine who is fascinated by Bosch. Therefore, despite having the same plot, the novel and the film are two separate, autonomous works.
Liver FoxO1 overexpression is positively associated with the degree of liver injury in cirrhotic patients
Authors: Fernández-Galán Esther , Sandalinas Silvia , Macias-Muñoz Laura , Portolés Irene , Ribera Jordi , Morales-Romero Blai , Pauta Montse , Casals Gregori , Boix Loreto , Jiménez Wladimiro , Morales-Ruiz Manuel
Published: July 2023

Objectives

Chronic liver disease and related complications, cirrhosis and hepatocellular carcinoma, are associated with high mortality. Curative treatments, partial hepatectomy or liver transplantation, have limited applicability in patients with cirrhosis due to the poor liver regenerative capacity. Thus, we need to find new diagnostic and therapeutic alternatives, to block the disease progression and to improve the survival of patients. In this context, preclinical studies have demonstrated the key role of the protein kinase B (Akt) in liver dysfunction, but the status of Akt and its targets in patients with chronic hepatopathy remains unknown. Aims: To determine the activation status of the Akt pathway and their association with liver functionality in cirrhotic patients.

Methods

This retrospective study includes liver tissue samples from 36 hepatectomized patients with (n=27) and without (n=9) cirrhosis. Multiplex analysis of proteins involved in the Akt/mTOR pathway was performed using a Luminex panel and Western blot. Conventional liver function tests were determined in serum before resection surgery.

Results

Akt and forkhead box protein O1 (FoxO1) are overexpressed in the liver of cirrhotic patients: (2.1 vs. 1.0 densitometric relative units (DRU); p<0.01, and 9.5 vs. 4.4 DRU; p<0.01, respectively). FoxO1 showed the best correlation with markers of liver injury (aspartate aminotransferase (ASAT): r=0.51, p<0.05; alanine aminotransferase (ALAT): r=0.49, p<0.05), and was the only enzyme in the Akt pathway identified as an independent predictor of ASAT and ALAT levels.

Conclusions

The intrahepatic expression of FoxO1 could have clinical utility as a potential prognostic marker for patients with advanced liver disease.
An Adaptive Two-Grid Solver for DPG Formulation of Compressible Navier–Stokes Equations in 3D
Authors: Rachowicz Waldemar , Cecot Witold , Zdunek Adam
Published: July 2023

We present an overlapping domain decomposition iterative solver for linear systems resulting from the discretization of compressible viscous flows with the Discontinuous Petrov–Galerkin (DPG) method in three dimensions.
It is a two-grid solver utilizing the solution on the auxiliary coarse grid and the standard block-Jacobi iteration on patches of elements defined by supports of the coarse mesh base shape functions.
The simple iteration defined in this way is used as a preconditioner for the conjugate gradient procedure.
Theoretical analysis indicates that the condition number of the preconditioned system should be independent of the actual finite element mesh and the auxiliary coarse mesh, provided that they are quasiuniform.
Numerical tests confirm this result.
Moreover, they show that presence of strongly flattened or elongated elements does not slow the convergence.
The finite element mesh is subject to adaptivity, i.e. dividing the elements with large errors until a required accuracy is reached.
The auxiliary coarse mesh is adjusting to the nonuniform actual mesh.
Simultaneous Recovery of Two Time-Dependent Coefficients in a Multi-Term Time-Fractional Diffusion Equation
Authors: Ma Wenjun , Sun Liangliang
Published: July 2023

This paper deals with an inverse problem on simultaneously determining a time-dependent potential term and a time source function from two-point measured data in a multi-term time-fractional diffusion equation.
First we study the existence, uniqueness and some regularities of the solution for the direct problem by using the fixed point theorem.
Then a nice conditional stability estimate of inversion coefficients problem is obtained based on the regularity of the solution to the direct problem and a fine property of the Caputo fractional derivative.
In addition, the ill-posedness of the inverse problem is illustrated and we transfer the inverse problem into a variational problem.
Moreover, the existence and convergence of the minimizer for the variational problem are given.
Finally, we use a modified Levenberg–Marquardt method to reconstruct numerically the approximate functions of two unknown time-dependent coefficients effectively.
Numerical experiments for three examples in one- and two-dimensional cases are provided to show the validity and robustness of the proposed method.
Correlation between the deformation of mineral crystal structures and fault activity: A case study of the Yingxiu-Beichuan fault and the Milin fault
Authors: Xie Chao , Zheng Meng , Liu Lei , Chen Baixu , Yang Fan , Wu Yongcai , He Siyuan
Published: July 2023

The build-up and occurrence of earthquakes are due to the accumulation and release of stress in fault zones. When subjected to tectonic extrusion stress, the crystal structure of the minerals within a fault zone will change. In this study, Raman spectroscopy analysis was conducted on the concurrently deposited quartz veins from Shenxigou, along the Yingxiu-Beichuan fault, and from Niyang River mouth, in the southern section of the Milin fault. The test results reveal a 3.29 cm−1 shift in the characteristic 464 cm−1 peak of the quartz in the veins along the fault plane of the Yingxiu-Beichuan fault, which was significantly lower than the shifts in the quartz peaks of the quartz on both sides of the vein. The 464 cm−1 peak shifts of the samples collected 10 m to the NW and 21 m to the SE of the fault plane were approximately 4.40 and 4.62 cm−1. In the veins from the Milin fault, considerable shifts of the 464 cm−1 quartz peaks occurred at the fault plane and to both sides within 5.5 m of the fault plane. No significant change in the 464 cm−1 Raman peak of quartz was observed for the samples 5–28 m to the SE of the fault plane. These results indicate that the tectonic extrusion stress accumulated more easily in proximity to the fault plane, resulting in significant changes in the crystals near the fault plane. We conclude that there is a correlation between the degree of change in the crystal structures of the minerals in thrust fault zones and fault activity, and such a correlation can provide a new method for studying the activity of thrust faults in areas with bedrock.
Spatiotemporal variation characteristics analysis of infrastructure iron stock in China based on nighttime light data
Authors: Huang Junchang , Yue Shuaijun , Ji Guangxing , Cheng Mingyue , Ma Hengyun , Hua Xuanke
Published: July 2023

Iron is one of the most important basic materials in infrastructure development, spatial and temporal variation characteristics analysis of infrastructure iron stocks is conducive to revealing its distribution and change patterns from different scales, which can provide a scientific basis for sustainable urban development and iron resource management in China. In this article, we first calculated provincial infrastructure iron stock data from 2000 to 2020. Then, fitting equations between nighttime lighting data and infrastructure iron stock are constructed to simulate the spatial distribution of China’s infrastructure iron stock at 500 m resolution from 2000 to 2020. Finally, the spatial and temporal dynamics of China’s infrastructure iron stock is analyzed from four scales: national, regional, provincial, and urban agglomeration. The results show as follows: (1) China’s infrastructure iron stock grew at an average annual rate of 26.42% from 2000 to 2020, with China’s infrastructure iron stock increasing 6.28 times over the 21 years. Construction facilities are the most important part of the infrastructure iron stock, and its share is still increasing. (2) On a regional scale, the high-growth type of infrastructure iron stock is mainly distributed in the eastern region, while the no-obvious-growth type is mainly distributed in the western region. The high grade of infrastructure iron stock is mainly distributed in the eastern region, while the low grade is mainly distributed in the western region. (3) On a provincial scale, the highest share of no-obvious-growth type of infrastructure iron stock is in Xinjiang. The highest proportion of infrastructure iron stock of high-growth type is in Jiangsu. The highest proportion of low-grade infrastructure iron stock is in Xinjiang. The highest proportion of infrastructure iron stock of high grade is in Beijing. (4) In terms of urban agglomerations, the high-growth type of infrastructure iron stock is mainly located in Shanghai–Nanjing–Hangzhou, while the no-obvious-growth type is mainly located in the Middle south of Liaoning. The high-grade infrastructure iron stock is mainly distributed in Shanghai–Nanjing–Hangzhou, while the low grade is mainly distributed in Sichuan–Chongqing.
Alterations in expression of α1-adrenergic receptors possibly are involved in prevention of age-associated apoptosis in rat hippocampus by treadmill exercise
Authors: Chodari Leila , Ghasemi Maedeh , Mehranfard Nasrin
Published: July 2023

Objectives

Exercise is assumed to attenuate age-related neuronal apoptosis, but the detailed mechanism(s) is not fully understood. α1-Adrenergic receptors (ARs) can either trigger or suppress apoptosis, therefore, here we determined the impact of treadmill exercise on the expression of the apoptosis regulatory proteins as well as α1-AR subtypes α1A- and α1B-ARs, in order to elucidate a possible association between apoptosis and the hippocampal expression of α1-ARs in aged male rats.

Methods

Twenty-one male Wistar rats were divided into 3 groups (n=7): young control, aged sedentary, and aged + exercise. Western blot for α1A- and α1B-ARs as well as pro-(Bax and p53) and anti-apoptotic (Bcl2) proteins was conducted. An 8-week regular moderate-intensity treadmill exercise intervention was carried out in exercise group.

Results

In aged rats, α1A-AR expression in the hippocampus was significantly increased, and exercise markedly prevented this event. While α1B-AR expression was no altered with aging, a marked reduction in α1B-AR level was detected in exercise group when compared to aged group. Furthermore, pro-apoptotic protein levels of Bax and p53 were upregulated and anti-apoptotic protein Bcl2 was downregulated in the aging hippocampus, but could be reversed by treadmill exercise. In the present research, exercise-induced reduction in α1A- and α1B-ARs was associated with an obvious downregulation of Bax/Bcl2 ratio in aged rats, suggesting that exercise may inhibit apoptosis through regulating α1-ARs, particularly α1A-AR.

Conclusions

Our study suggests that manipulations attenuating α1-AR activity, including nonselective α1-adrenergic antagonists, may protect against hippocampal neurodegeneration in aging brains.
The Call to Selfhood: Kierkegaard, Narrative Unity, and the Achievement of Personal Identity
Authors: Farris Jacob
Published: July 2023

This paper argues for a Kierkegaardian account of personal identity in dialogue with MacIntyre, Korsgaard, Frankfurt, Ricœur, and Marion. I engage with the scholarly debate on Kierkegaard’s relationship to practical and narrative accounts of the self and argue that he criticizes the ideal of self-authorship because authentic selfhood must be co-authored with others and embedded in the narrative setting and history that is provided by facticity. Moreover, this relation to facticity requires ethical commitment and existential faith. The phenomenology of the call can show how such commitment and faith overcomes self-alienation by synthesizing the passive and active aspects of selfhood.
Kierkegaard and Religionswissenschaft: A Source- and Reception-Historical Survey (Part 2)
Authors: Ziolkowski Eric
Published: July 2023

This second part of a two-part article (the first part of which appeared in the Kierkegaard Studies Yearbook 2022) surveys the varying uses made of Kierkegaard’s writings by four twentieth- and, in two of their cases, also twenty-first-century contributors to Religionswissenschaft: Joachim Wach, Mircea Eliade, Wendy Doniger, and Bruce Lincoln, all four of whom happen to have taught at the University of Chicago Divinity School. Far from being irrelevant or being regarded as a theologically-inclined persona non grata by comparatists of religion, Kierkegaard was embraced in three main capacities by these influential contributors to the field: as a datum (mostly in the history of theology and/or philosophy), as a theorist, and, in one case, as an existential soulmate. In Lincoln’s case, the reduction to memes—the memeification—of certain ideas ascribed to Kierkegaard comes under consideration.
Highly directional single-photon source
Authors: Manjavacas Alejandro , García de Abajo F. Javier
Published: July 2023

Single-photon emitters are a pivotal element in quantum technologies, but the generation of single photons along well-defined directions generally involves sophisticated configurations. Here, we propose a photon source capable of generating single photons with high efficiency along guided modes. Specifically, we consider a quantum emitter placed in a periodically patterned linear waveguide. The latter is designed to host a single guided mode over the spectral range of interest and display a divergence in the photonic density of states at an emission wavelength close to the period. Photons are preferentially emitted along the waveguide near that spectral region. We predict that nearly all of the emission can be made to occur along the waveguide with a reduction in the temporal uncertainty by two orders of magnitude. Our study opens a conceptually new direction in the production of single photons with a high degree of directionality and reduced temporal uncertainty.
Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films
Authors: Feng Yanping , Jupei Zhang , Dong Zhihong , Tang Lu
Published: July 2023

In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, and the SF/PCL composite nanofiber films were characterized by the combined techniques of scanning electron microscopy (SEM), the equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) and cell viability test. The results indicated several parameters, including the rotating roller speed, solution concentration, and SF/PCL ratio, affected SF/PCL composite nanofibers’ diameter size, distribution, and wettability. The SF/PCL composite nanofiber manifested a smaller fiber diameter and more uniform nanofibers than pure PCL nanofibers. The contact angle changed from 121 ± 2° of the neat pure PCL to full wetting of 40% SF/PCL composite nanofiber films at 2,000 rpm, indicating good hydrophilicity. Meanwhile, cells exhibit adhesion and proliferation on the composite nanofiber films. These results testified that SF/PCL composite nanofiber films may provide good wettability for cell adhesion and proliferation. It was suggested that optimized SF/PCL composite nanofiber films could be used as a potential biological dressing for skin wound healing.
The Educational Responsibilities of Philosophers
Authors: Brighouse Harry
Published: July 2023

Perpetuating the discipline of philosophy is not the main educational responsibility of philosophers. Instead, it is to equip students with those distinctively philosophical intellectual resources that will serve students in serving the public good through participation in the economy (broadly conceived) and democratic life. Given this responsibility philosophers, individually and collectively, have a duty to take teaching and learning more seriously than they do. The paper offers some confident ideas about what this means when it comes to approaching training and professional development and some more tentative ideas about what it means, specifically, for the Philosophy curriculum and the pedagogical strategies philosophers should adopt in the classroom.
Windkanalmesseinrichtung für das bistatische PTB-Wind-Lidar
Authors: Oertel Stefan , Eggert Michael , Wilhelm Paul , Hornig Julia
Published: July 2023

Im Zusammenhang mit dem Erreichen der Klimaziele durch den Einsatz erneuerbarer Energien wurde in der Physikalisch-Technischen Bundesanstalt (PTB) in den letzten Jahren ein bistatisches Wind-Lidar (Light detection and ranging) entwickelt und aufgebaut. Dieses Wind-Lidar ermöglicht die für Windenergieanlagen notwendige Rückführung von Windgeschwindigkeiten in Höhen von 5 m bis 250 m mit kleinsten Messunsicherheiten in beliebigem Gelände, und stellt damit erstmals eine unabhängige Alternative zu bisher eingesetzten, kostspieligen Windmessmasten dar. Der geplante Einsatz des PTB-Lidars als rückgeführtes Transfernormal im Bereich der Windfernmessung erfordert neben vorherigen Vergleichsmessungen mit anderen Windfernmesssystemen in freiem Gelände auch eine detaillierte Untersuchung des PTB-Lidars unter kontrollierbaren Strömungsbedingungen zur Validierung seiner Messunsicherheit und Überwachung seiner Langzeitstabilität. Aus diesem Grund wurde im Kompetenzzentrum für Windenergie (CCW) der PTB ein neuer, speziell konstruierter Windkanal mit einem Laser-Doppler-Anemometer (LDA) als Strömungsgeschwindigkeitsnormal auf einer Plattform in 8 m Höhe errichtet. Dies ermöglicht es, das PTB-Lidar unterhalb der Messstrecke des Windkanals zu positionieren und auf die SI-Einheiten-rückgeführte Strömungsgeschwindigkeitsmessungen mit dem Wind-Lidar durchzuführen. Der Windkanal nach Göttinger Bauart hat eine offene Messstrecke mit einer Länge von 75 cm und einer Querschnittsfläche von 50 × 50 cm2. In der Messstrecke wird eine hohe Strömungshomogenität und ein niedriger Turbulenzgrad von <0,35 % im Geschwindigkeitsbereich von 1 m/s bis 30 m/s erreicht. Die erweiterte Messunsicherheit des LDA-Referenznormals beträgt 0,16 %. Sämtliche im Windkanal durchgeführten Vergleichsmessungen zeigen eine Geschwindigkeitsabweichung zwischen dem Lidar-System und dem LDA-Referenznormal von unter ±0,5 %. Eine Optimierung der Methode zur Positionierung und damit Lokalisierung des Lidar-Messvolumens in der Windkanalmessstrecke über einen dünnen Partikelfilm führte zu einer reproduzierten Verringerung der Geschwindigkeitsabweichung auf circa −0,10 %.
Pneumocystis jirovecii pneumonia and deep vein thrombosis in a patient with glioblastoma multiforme
Authors:   Larkin Community Hospital, Department of Internal Medicine, Miami, FL, USA, Hussain Hussain , Paidas Michael ,   University of Miami Miller School of Medicine Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL, USA, Fadel Aya ,   Department of Internal Medicine at Ocean Medical Center, Brick City, New Jersey, USA, Garcia Efrain ,   Larkin Community Hospital, Department of Internal Medicine, Miami, FL, USA, Saadoon Zahraa ,   University of Baghdad School of Medicine, Baghdad, Iraq, Mendez Luis ,   Larkin Community Hospital, Department of Internal Medicine, Miami, FL, USA, Jayakumar Arumugam ,   University of Miami Miller School of Medicine Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
Published: July 2023

We present a case of disseminated Pneumocystis jirovecii pneumonia in a patient with a medical history of glioblastoma multiforme associated with acute deep-vein thrombosis. The patient presented to the emergency department with clinical features of pulmonary infection, and the chest images showed pneumonia. Antibiotics were initiated (azithromycin, cefepime, and vancomycin) and the patient was transferred to the ward for further management, where the condition of the patient continued to worsen over the second day. The patient developed bilateral lower extremity swelling and the doppler ultrasound revealed bilateral lower extremity acute deep vein thrombosis. Laboratory results showed pancytopenia and transaminitis. However, a repeated chest X-ray showed groundglass changes and interstitial infiltrates, suggestive of atypical infection. We indeed identified D-glucan which hints to a disseminated form of Pneumocystis jirovecii pneumonia infection in this patient. We further confirmed the Pneumocystis jirovecii pneumonia by polymerase chain reaction test from the fluid obtained via bronchoalveolar lavage. We, therefore, initiated intravenous trimethoprim/sulfamethoxazole treatment with an anticoagulant, and the patient’s condition improved. Our findings strongly suggest a possible link between Pneumocystis jirovecii pneumonia infection and thrombogenesis, with impact in medical practice.
Um passado (quase) esquecido: o sítio Baquirivu-Mirim e o primeiro Ciclo do Ouro brasileiro
Authors: Damin Pedro Henrique , Attorre Tiago , Brandi Rafael , Acha Milena
Published: July 2023

A mineração do ouro foi uma das mais importantes atividades econômicas durante o período colonial brasileiro. Para além das áreas minerárias tradicionais da América Portuguesa, como Minas Gerais e Goiás, outras regiões menos conhecidas também passaram por ciclos de exploração aurífera, como a atual Região Metropolitana de São Paulo. Visando contribuir com uma discussão já em curso no âmbito da História e Arqueologia, ao longo deste artigo apresentaremos informações referentes a um sítio de mineração colonial caracterizado por engenharia de solo e estruturas de manejo hídrico, identificado em Guarulhos durante uma pesquisa arqueológica preventiva. Provavelmente explorado durante os séculos XVII e XVIII, o sítio Baquirivu-Mirim contribui para uma história da mineração do ouro em São Paulo, atividade de grande importância para assentamentos coloniais na região. Abstract:Mining was one of the most important economic activities during the Brazilian colonial period. Beyond the traditional mining areas of Portuguese America, like Minas Gerais and Goiás, other less known regions were also subjected to cycles of gold exploration, like present Metropolitan São Paulo Region. Aiming to contribute to an already initiated discussion in History and Archaeology, over this article we will present information concerning a colonial mining site characterized by soil engineering and hydric management structures identified during CRM activities at Guarulhos city urban area. Probably explored during the XVIIth and XVIIIth centuries, the Baquirivu-Mirim site contributes to a history of gold mining in São Paulo, activity of utmost importance to the colonial settlements in the region.
Datação de argamassa e tijolo da portada principal do Forte Orange, Itamaracá, Pernambuco
Authors: Lavalle Sullasi Henry Sócrates , Figueirôa Santos Clara Diana , Rojas Rocca Rene , Khoury Asfora Viviane , Albuquerque Marcos
Published: July 2023

Este trabalho teve por objetivo datar argamassa e tijolos do período colonial pernambucano pela técnica de Luminescência Opticamente Estimulada (LOE), utilizando o protocolo SAR. Como objeto de estudo foram usados tijolos amarelos e vermelhos, assim como argamassa proveniente de vestígios construtivos da Portada Principal do Forte Orange, Itamaracá. Os resultados mostraram que a argamassa e o tijolo amarelo apresentam intervalos cronológicos similares, ao redor de 1606±37 d.C. e 1609±118 d.C, respectivamente, de forma condizente à data de construção da portada em estudo. Entretanto a cronologia obtida para o tijolo vermelho, não foi compatível com a presente construção, se referindo a um intervalo de 1407±19 d.C que indica a possibilidade de este ter sido fruto de um reaproveitamento construtivo de sua região de proveniência, considerada, a partir dos dados expostos, como possivelmente a cidade de Leiden na Holanda. Estes resultados, de forma geral, mostram a possibilidade de uso da técnica de LOE, pelo protocolo SAR, no propósito de inserir cronologicamente as argamassas coloniais, entre elas, as de Pernambuco.
Combinatory Actions of Co-transmitters in Dopaminergic Systems ModulateDrosophilaOlfactory Memories
Authors: Yamazaki Daisuke , Maeyama Yuko , Tabata Tetsuya
Published: July 2023

Dopamine neurons (DANs) are extensively studied in the context of associative learning, in both vertebrates and invertebrates. In the acquisition of male and femaleDrosophilaolfactory memory, the PAM cluster of DANs provides the reward signal, and the PPL1 cluster of DANs sends the punishment signal to the Kenyon cells (KCs) of mushroom bodies, the center for memory formation. However, thermo-genetical activation of the PPL1 DANs after memory acquisition impaired aversive memory, and that of the PAM DANs impaired appetitive memory. We demonstrate that the knockdown of glutamate decarboxylase, which catalyzes glutamate conversion to GABA in PAM DANs, potentiated the appetitive memory. In addition, the knockdown of glutamate transporter in PPL1 DANs potentiated aversive memory, suggesting that GABA and glutamate co-transmitters act in an inhibitory manner in olfactory memory formation. We also found that, in γKCs, the Rdl receptor for GABA and the mGluR DmGluRA mediate the inhibition. Although multiple-spaced training is required to form long-term aversive memory, a single cycle of training was sufficient to develop long-term memory when the glutamate transporter was knocked down, in even a single subset of PPL1 DANs. Our results suggest that the mGluR signaling pathway may set a threshold for memory acquisition to allow the organisms' behaviors to adapt to changing physiological conditions and environments.

SIGNIFICANCE STATEMENTIn the acquisition of olfactory memory inDrosophila, the PAM cluster of dopamine neurons (DANs) mediates the reward signal, while the PPL1 cluster of DANs conveys the punishment signal to the Kenyon cells of the mushroom bodies, which serve as the center for memory formation. We found that GABA co-transmitters in the PAM DANs and glutamate co-transmitters in the PPL1 DANs inhibit olfactory memory formation. Our findings demonstrate that long-term memory acquisition, which typically necessitates multiple-spaced training sessions to establish aversive memory, can be triggered with a single training cycle in cases where the glutamate co-transmission is inhibited, even within a single subset of PPL1 DANs, suggesting that the glutamate co-transmission may modulate the threshold for memory acquisition.
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation
Authors: Laroussi Hamida , Juarez‐Martinez Ariadna B , Le Roy Aline , Boeri Erba Elisabetta , Gabel Frank , de Massy Bernard , Kadlec Jan
Published: July 2023

Meiotic recombination is initiated by the formation of DNA double‐strand breaks (DSBs), essential for fertility and genetic diversity. In the mouse, DSBs are formed by the catalytic TOPOVIL complex consisting of SPO11 and TOPOVIBL. To preserve genome integrity, the activity of the TOPOVIL complex is finely controlled by several meiotic factors including REC114, MEI4, and IHO1, but the underlying mechanism is poorly understood. Here, we report that mouse REC114 forms homodimers, that it associates with MEI4 as a 2:1 heterotrimer that further dimerizes, and that IHO1 forms coiled‐coil‐based tetramers. Using AlphaFold2 modeling combined with biochemical characterization, we uncovered the molecular details of these assemblies. Finally, we show that IHO1 directly interacts with the PH domain of REC114 by recognizing the same surface as TOPOVIBL and another meiotic factor ANKRD31. These results provide strong evidence for the existence of a ternary IHO1‐REC114‐MEI4 complex and suggest that REC114 could act as a potential regulatory platform mediating mutually exclusive interactions with several partners.
THE EFFECTS OF SERVICE QUALITY ON PATIENT’S SATISFACTION IN PUSAT KESIHATAN MASYARAKAT (PUSKESMAS)
Authors: Razali Suryadi Cut Ubit
Published: July 2023

Service quality is a form of patient assessment of the level of service received with the expected level of service. Satisfaction is a feeling of pleasure or disappointment that someone feels after comparing with the services provided. Patient satisfaction with the quality of health services is needed because it causes patients to be loyal to check their health at health care institutions. This study aims to determine the effect of service quality on patient satisfaction at Puskesmas ISO, and Non-ISO certified viewed from five dimensions of service quality, tangibles, reliability, responsiveness, assurance, and empathy. Data were collected using questionnaires, and samples were taken by purposive sampling in patients who were treated at Puskesmas who had met the requirements of 600 people, namely 300 people from Puskesmas ISO and 300 people from Non-ISO. Data were analysed by using simple linear regression test and multiple linear regression with the help of Amos version 22 software. The results of bivariate tests at Puskesmas ISO, all dimensions namely tangibles, reliability, responsiveness, assurance, empathy and quality of service influence patient satisfaction, while in Puskesmas Non-ISO all dimensions of service quality and service quality do not affect patient satisfaction. The key findings demonstrates quality of service in Puskesmas ISO is better and has an impact on patient satisfaction. This research’s implication offers a guideline on issues of increasing patient satisfaction with the quality of health services, and it is essential for regulatory agencies to examine and improve the quality of public health services.
FACTORS INFLUENCING NURSING JOB SATISFACTION IN STATE AND PRIVATE HOSPITALS IN BANDA ACEH INDONESIA
Authors: Rachmiana Aida
Published: July 2023

Job satisfaction is an essential problem for all organisations including hospitals, regardless of state property or private property in providing health services. This study aims to determine the effect of work itself, promotions, working condition, pay, supervision and co-worker relationship to nursing job satisfaction in a state hospital and a private hospital in Banda Aceh. This research is a comparative cross-sectional study and the data collection tool in the form of a questionnaire. The sample in this study was conducted by purposive sampling with a total of 353 nurses namely 213 state hospital nurses and 140 private hospitals nurses. The data were analysed using the Pearson correlation test, simple linear regression, Independent sample t-test and multiple linear regression. The results of the bivariate study showed a relationship and influence of the factors of work itself, promotion, working condition, pay, supervision and co-worker relationship on the job satisfaction of nurses in both hospitals. The results also showed that there were significant differences in the work itself, promotion, working condition, pay, supervision, co-worker relationship and nurse job satisfaction between the two hospitals.
SUNNAH ALLAH BERKENAAN BANGUN DAN JATUH TAMADUN MENURUT AL-QURAN DAN TEORI-TEORI TAMADUN: SUATU PENELITIAN PERBANDINGAN
Authors: Sulaiman Mansor , Ahmad Hasan
Published: July 2023

Sunnatullah (The Command of Allah) in the rise and fall of human civilization has actually been destined by God and the matter was heavily mentioned in the al-Quran. This paper aims at clarifying the truth of the Sunnatullah as revealed in the al-Quran by comparing with studies carried out by renowned historical and civilizational scholars. To examine, these civilization advancement theories that have been empirically studies by the scholars such as Ibn Khaldun, Arnold Toynbee and Malik Bennabi are comparatively analysed with those mentioned in the al-Quran. Through this comparative analysis, it is concluded undoubtedly that the Sunnatullah of the rise and fall of civilization as revealed in the al-Quran is a great truth. This conclusion is made based on the consistency of the Quranic facts with the findings given by the scholars through historical proofs and human reality in life.
 
Sunnah Allah berkenaan bangun dan jatuh tamadun merupakan peraturan yang ditentukan Allah di sebalik perjalanan sesebuah tamadun manusia. Ia merupakan salah satu daripada perkara yang banyak disentuh di dalam al-Quran. Tulisan ini bertujuan menjelaskan kesahihan Sunnah Allah yang dikemukakan al-Quran ini menerusi perbandingan dengan kajian-kajian yang telah dilakukan oleh beberapa sarjana dalam bidang sejarah dan tamadun manusia. Untuk itu, teori-teori perkembangan tamadun yang dihasilkan menerusi kajian berbentuk empirikal yang dilakukan oleh tokoh-tokoh seperti Ibnu Khaldun, Arnold Toynbee dan Malek Bennabi dikaji dan seterusnya dilakukan analisis perbandingan antara penjelasan al-Quran dan teori-teori ini. Menerusi analisis perbandingan ini didapati bahawa Sunnah berkenaan bangun dan jatuh tamadun yang dikemukakan Allah menerusi al-Quran merupakan suatu kebenaran yang tidak dapat dinafikan kesahihannya. Kesimpulan ini dikemukakan berdasarkan kepada keselarian antara penjelasan al-Quran berkenaan sunnah Allah ini dengan penemuan kajian yang dikemukakan para sarjana yang berkenaan menerusi bukti-bukti sejarah dan realiti yang berlaku dalam hidup manusia.
KEBOLEHLAKSANAAN PEMBELAJARAN MELALUI APLIKASI MICROSOFT TEAMS DI KOLEJ KOMUNITI KOTA MARUDU, SABAH
Authors: Abdul Wahab Khairul Izwan , Zulkurnain bin Hassan
Published: July 2023

This study aims to identify the perception of students of Kolej Komuniti Kolej Komuniti Marudu, Sabah (KKKMS) about the learning experience and the obstacles faced in using the Microsoft Teams application in teaching and learning. A total of 70 KKKMS students from all programs were taken as study respondents. This study was conducted using a questionnaire as a research instrument and the data was analyzed descriptively and inferentially. Data analysis was processed using Statistical Packages for Social Sciences for Windows Version 22.0 (SPSS) software and the results of the study were reported in the form of mean, standard deviation, percentage and T-Test". The results show that the level of perception of the Microsoft Teams Official application learning experience is high (mean 3.66). Barriers were tested in six aspects where there were four main barriers faced which were the highest technological barriers (mean 3.52), the second highest were situational barriers (mean 3.40), the third were learning style barriers (mean 3.26) and the fourth highest barrier was instructional barriers (mean 3.11). The findings also found that there is no significant relationship between learning experiences and the obstacles faced by students.
 
Kajian ini bertujuan untuk mengenalpasti persepsi pelajar Kolej Komuniti Kota Marudu, Sabah (KKKMS) tentang pengalaman pembelajaran dan halangan-halangan yang dihadapi dalam penggunaan aplikasi Microsoft Teams dalam pengajaran dan pembelajaran. Seramai 70 orang pelajar KKKMS dari semua program diambil sebagai responden kajian. Kajian ini dijalankan dengan menggunakan borang soal selidik sebagai instrumen kajian dan data dianalisis secara deskriptif dan inferensi. Data analisis diproses menggunakan perisian Statistical Packages for Social Sciences for Windows Version 22.0 (SPSS) dan hasil dapatan kajian dilaporkan dalam bentuk min, sisihan piawaian, peratusan dan Ujian T-Test”. Hasil dapatan menunjukkan tahap persepsi pengalaman pembelajaran aplikasi Microsoft Teams Official adalah tinggi (min 3.66). Halangan diuji dalam enam aspek dimana terdapat empat halangan utama yang dihadapi iaitu tertinggi halangan teknologi (min 3.52), kedua tertinggi halangan situasi (min 3.40), ketiga halangan gaya pembelajaran (min 3.26) dan halangan keempat tertinggi adalah halangan arahan (min 3.11). Dapatan juga mendapati tidak terdapatnya hubungan yang signifikan antara pengalaman pembelajaran dengan halanganhalangan yang dihadapi pelajar.
THE DILEMMAS OF ADOPTING A FOREIGN MODEL INTO LOCAL CONTEXT: A CASE OF LESSON STUDY IN MALAYSIAN UNIVERSITY TEACHING
Authors: Mia Emily A. R.  , Marini Emma
Published: July 2023

The lesson study model was initially introduced in Japan as a core for professional development among teachers and a tool for improvement of teaching and learning. It has since become a global phenomenon and adoption of the idea was widespread across many countries (Lewis & Tsuchida, 1998; Stigler & Hiebert, 1999; Yoshida, 1999). This study aims to describe the challenges of implementing lesson study model on undergraduate English lecturers from a private university in Kuala Lumpur and a public university in Terengganu. Specifically, this article serves to address the lecturers’ dilemmas in context of lesson study model that were focused on the aspects of bureaucracy, teacher readiness and cultural conflict. This study employs a qualitative research design through observations and interviews. The findings of the study are essential in providing an insight to the considerations that need to be taken into account when appropriating a borrowed educational model into local contex.