bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of bump defects formed in back end of line for 28 nm technological node
Authors: Zhou Ming , Hao Deng , Beichao Zhang
Published: May 2016

In order to quickly ramp up and maintain good yield, it was very important that the bump defects as the killer for 28 nm technological node were accurately detected, and the quantities of the bump defects rapidly decreased by the adjusting processes. The main purpose of this paper was to investigate the performance of the bump defects in the back end of line for 28 nm technology and detect the seeds of the forming bump defect. Firstly, the bump defects were scanned by the optical examination instrument. Subsequently, the scanned defect map was transferred into scanning electron microscopy reviewing system to observe the types and sizes of the bump defects. For finding the seed of forming the bump defect, the defects were cut from the wafer using a focused ion beam, and then a transmission electron microscope was used for observing interface to identify the location of the seed of forming the bump defect. Results showed that the bump defect originated from the interface between metal (after chemical mechanical polish) and dielectric cap layer. In addition, an in‐depth study of the formation of the bump defect was carried out using the different film stacks. Copyright © 2016 John Wiley & Sons, Ltd.
The Impact of Formal and Informal Distance on Gender Equality Approaches: The Case of a British MNC in Saudi Arabia
Authors: Alhejji Hussain , Ng Eddy S. , Garavan Thomas , Carbery Ronan
Published: May 2016

This study explores the forces that promote and hinder gender equality efforts of a multinational corporation (MNC) operating in the Middle East. Specifically, we draw from a case study to document the formal and informal pressures exerted on a British MNC operating in Saudi Arabia to better understand the multiple forces that influence gender equality approaches in the host country. Our findings suggest that while formal institutions such as the legal requirements and localization policies support gender equality, informal forces that are rooted in the cultural norms and traditions are formidable in hindering such efforts and in reinforcing the status quo. The insights generated from our study have the potential to inform public policy makers and organizational decision makers to locate the right policy tool to promote gender equality. © 2016 Wiley Periodicals, Inc.
TAPP or TEP for Recurrent Inguinal Hernia? Population‐Based Analysis of Prospective Data on 1309 Patients Undergoing Endoscopic Repair for Recurrent Inguinal Hernia
Authors: Gass M. , Scheiwiller A. , Sykora M. , Metzger J.
Published: May 2016

Background

Whether total extraperitoneal inguinal hernia repair (TEP) is associated with worse outcomes compared to transabdominal preperitoneal inguinal hernia repair (TAPP) for the treatment of recurrent inguinal hernia continues to be a matter of debate. The objective of this large cohort study is to compare complications, conversion rates and postoperative length of hospital stay between patients undergoing TEP or TAPP for unilateral recurrent inguinal hernia repair.

Method

Based on prospective data of the Swiss Association of Laparoscopic and Thoracoscopic Surgery, all patients who underwent elective TEP or TAPP for unilateral recurrent inguinal hernia between 1995 and 2006 were included. The following outcomes were compared: conversion rates, intraoperative complications, surgical postoperative complications and duration of operation.

Results

Data on 1309 patients undergoing TEP (n = 1022) and TAPP (n = 287) for recurrent inguinal hernia were prospectively collected. Average age, BMI and ASA score were similar in both groups. Patients undergoing TEP had a significantly increased rate of intraoperative complications (TEP 6.3 % vs. TAPP 2.8 %, p = 0.0225). Duration of operation was longer for patients undergoing TEP (TEP 80.3 vs. TAPP 73.0 min, p < 0.0023) while postoperative length of hospital stay was longer for patients undergoing TAPP (TEP 2.6 vs. TAPP 3.1 day, p = 0.0145). Surgical postoperative complications (TEP 3.52 % vs. TAPP 2.09 %, p = 0.2239), general postoperative complications (TEP 1.47 % vs. TAPP 0.7 %, p = 0.3081) and conversion rates (TEP 2.15 % vs. TAPP 1.39 %, p = 0.4155) were not significantly different.

Conclusion

This study is the first population‐based analysis comparing outcomes of patients with recurrent inguinal hernia undergoing TEP versus TAPP in a prospective cohort of over 1300 patients. Intraoperative complications were significantly higher in patients undergoing TEP. The TEP technique was associated with longer operating times, but a shorter postoperative length of hospital stay. Nonetheless, the absolute outcome differences are small and thus, on a population‐based level, both techniques appear to be safe and effective for patients undergoing endoscopic repair for unilateral recurrent inguinal hernia.
Effect of Prior Austenite Grain Size Refinement by Thermal Cycling on the Microstructural Features of As-Quenched Lath Martensite
Authors: Hidalgo Javier , Santofimia Maria Jesus
Published: May 2016

Current trends in steels are focusing on refined martensitic microstructures to obtain high strength and toughness. An interesting manner to reduce the size of martensitic substructure is by reducing the size of the prior austenite grain (PAG). This work analyzes the effect of PAGS refinement by thermal cycling on different microstructural features of as-quenched lath martensite in a 0.3C-1.6Si-3.5Mn (wt pct) steel. The application of thermal cycling is found to lead to a refinement of the martensitic microstructures and to an increase of the density of high misorientation angle boundaries after quenching; these are commonly discussed to be key structural parameters affecting strength. Moreover, results show that as the PAGS is reduced, the volume fraction of retained austenite increases, carbides are refined and the concentration of carbon in solid solution as well as the dislocation density in martensite increase. All these microstructural modifications are related with the manner in which martensite forms from different prior austenite conditions, influenced by the PAGS.
Buddhist psychology: Selected insights, benefits, and research agenda for consumer psychology
Authors: Mick David Glen
Published: May 2016

Consumer psychology has been overly reliant on a small set of paradigms. As a result, the field appears less prepared than it could aspire to be for contributing new knowledge on, and relief from, our hyper‐consumption era. Accordingly, I explore Buddhist psychology by drawing from its foundational framework known as the Three Marks of Existence (suffering, impermanence, and no‐self) to introduce an Eastern theory of mind and provide alternative guidance on research for consumer well‐being. The TME framework offers an opportunity to re‐think the priorities, nature, and processes of the comparing and judging consumer mind (e.g., expectations, preferences, satisfaction); the attaching and depending consumer mind (e.g., ownership, materialism, excessive behaviors); and the deciding, choosing, and regulating consumer mind (marketplace morality, cognitive biases, values‐based choice, and free will). From these considerations I generate research questions and summarizing propositions for future research. The closing discussion synopsizes the contributions and limitations, including extra opportunities for integrating Buddhist and consumer psychologies.
Early oral tongue cancer initially managed with surgery alone: Treatment of recurrence
Authors: Liu Jeffrey C. , Sopka Dennis S. , Mehra Ranee , Lango Miriam N. , Fundakowski Christopher , Ridge John A. , Galloway Thomas J.
Published: May 2016

Objective

To report T1‐2N0 tongue cancer recurrences initially treated with surgery alone.

Methods

Between 1990 and 2010, 27 patients at tertiary hospital referral center institution were treated with curative intent for locoregional recurrence after initial glossectomy with or without neck dissection for T1‐2N0 tongue cancer. None had received adjuvant postoperative radiation as a component of the original treatment.

Results

Median time to locoregional recurrence was 12 months (range 5–39 months) and 78% of failures occurred in the first 2 years. Most treatment failures were local (63%). Salvage strategy was risk‐adapted by individual patient. The 5‐year disease specific survival (DSS) was 61%. Patients with local recurrences alone fared significantly better than those with regional recurrences (5‐yr DSS: 86% vs. 22%, P = 0.0018). Local recurrences were usually treated by surgery alone, while regional recurrences were more commonly treated with combined modality treatment (P = 0.005).

Conclusions

Recurrence of early stage oral tongue cancer can be successfully salvaged in a majority of cases. Patients developing regional recurrence have significantly worse prognosis than those with local failures.
SIMPLE CONTINUITY INEQUALITIES FOR RUIN PROBABILITY IN THE CLASSICAL RISK MODEL
Authors: Gordienko Evgueni , Vázquez-Ortega Patricia
Published: May 2016

A simple technique for continuity estimation for ruin probability in the compound Poisson risk model is proposed. The approach is based on the contractive properties of operators involved in the integral equations for the ruin probabilities. The corresponding continuity inequalities are expressed in terms of the Kantorovich and weighted Kantorovich distances between distribution functions of claims. Both general and light-tailed distributions are considered.
Quantum Monte Carlo Methods
Authors: Gubernatis James , Kawashima Naoki , Werner Philipp
Published: May 2016

Featuring detailed explanations of the major algorithms used in quantum Monte Carlo simulations, this is the first textbook of its kind to provide a pedagogical overview of the field and its applications. The book provides a comprehensive introduction to the Monte Carlo method, its use, and its foundations, and examines algorithms for the simulation of quantum many-body lattice problems at finite and zero temperature. These algorithms include continuous-time loop and cluster algorithms for quantum spins, determinant methods for simulating fermions, power methods for computing ground and excited states, and the variational Monte Carlo method. Also discussed are continuous-time algorithms for quantum impurity models and their use within dynamical mean-field theory, along with algorithms for analytically continuing imaginary-time quantum Monte Carlo data. The parallelization of Monte Carlo simulations is also addressed. This is an essential resource for graduate students, teachers, and researchers interested in quantum Monte Carlo techniques.
Women in Twentieth-Century Africa
Authors: Berger Iris
Published: May 2016

During a turbulent colonial and postcolonial century, African women struggled to control their own marital, sexual and economic lives and to gain a significant voice in local and national politics. This book introduces students to many remarkable women, who organized religious and political movements, fought in anti-colonial wars, ran away to escape arranged marriages, and during the 1990s began successful campaigns for gender parity in national legislatures. The book also explores the apparent paradox in the conflicting images of African women - as singularly oppressed and dominated by men, but also as strong, resourceful, and willing to challenge governments and local traditions to protect themselves and their families. Understanding the tension between women's power and their oppression, between their strength and their vulnerability, offers a new lens for understanding the relationship between the state and society in the twentieth century.
Intellectual Networks in Timurid Iran
Authors: Binbaş İlker Evrim
Published: May 2016

By focusing on the works and intellectual network of the Timurid historian Sharaf al Dīn 'Alī Yazdī (d.1454), this book presents a holistic view of intellectual life in fifteenth century Iran. İlker Evrim Binbaş argues that the intellectuals in this period formed informal networks which transcended political and linguistic boundaries, and spanned an area from the western fringes of the Ottoman State to bustling late medieval metropolises such as Cairo, Shiraz, and Samarkand. The network included an Ottoman revolutionary, a Mamluk prophet, and a Timurid occultist, as well as physicians, astronomers, devotees of the secret sciences, and those political figures who believed that the network was a force to be taken seriously. Also discussing the formation of an early modern Islamicate republic of letters, this book offers fresh insights on the study of intellectual history beyond the limitations imposed by nationalist methodologies, established genres, and recognized literary traditions.
Language and Development in Africa
Authors: Wolff H. Ekkehard
Published: May 2016

Development is based on communication through language. With more than two thousand languages being used in Africa, language becomes a highly relevant factor in all sectors of political, social, cultural and economic life. This important sociolinguistic dimension hitherto remains underrated and under-researched in 'Western' mainstream development studies. The book discusses the resourcefulness of languages, both local and global, in view of the ongoing transformation of African societies as much as for economic development. From a novel 'applied African sociolinguistics' perspective it analyses the continuing effects of linguistic imperialism on postcolonial African societies, in particular regarding the educational sector, through imposed hegemonic languages such as Arabic and the ex-colonial languages of European provenance. It offers a broad interdisciplinary scientific approach to the linguistic dimensions of sociocultural modernisation and economic development in Africa, written for both the non-linguistically trained reader as much as for the linguistically trained researcher and language practitioner.
From Self to Social Relationships
Authors: van Zomeren Martijn
Published: May 2016

What is it that moves and motivates us in our lives? Martijn van Zomeren proposes social relationships are at the essence of this key question and, in a fascinating investigation into human motivation, he develops a novel and integrative psychological theory termed 'selvations theory'. The theory suggests that we are essentially relational beings that seek to regulate relationships in response to felt changes in our network of relationships (selvations). However, we need to do this in culturally appropriate ways and this is where our culturally construed self comes to be of use. From Self to Social Relationships constitutes a powerful argument about human essence, integrating major theories in and around psychology, which has strong implications for the study and practice of social motivation.
200 More Puzzling Physics Problems
Authors: Gnädig Péter , Honyek Gyula , Vigh Máté
Published: May 2016

Like its predecessor, 200 Puzzling Physics Problems, this book is aimed at strengthening students' grasp of the laws of physics by applying them to situations that are practical, and to problems that yield more easily to intuitive insight than to brute-force methods and complex mathematics. The problems are chosen almost exclusively from classical, non-quantum physics, but are no easier for that. They are intriguingly posed in accessible non-technical language, and require readers to select an appropriate analysis framework and decide which branches of physics are involved. The general level of sophistication needed is that of the exceptional school student, the good undergraduate, or the competent graduate student; some physics professors may find some of the more difficult questions challenging. By contrast, the mathematical demands are relatively minimal, and seldom go beyond elementary calculus. This further book of physics problems is not only instructive and challenging, but also enjoyable.
Imagined Sovereignties
Authors: Olson Kevin
Published: May 2016

Movements like the Arab Spring, Occupy Wall Street, and the Tea Party embody some of our deepest intuitions about popular politics and 'the power of the people'. They also expose tensions and shortcomings in our understanding of these ideals. We typically see 'the people' as having a special, sovereign power. Despite the centrality of this idea in our thinking, we have little understanding of why it has such importance. Imagined Sovereignties probes the considerable force that 'the people' exercises on our thought and practice. Like the imagined communities described by Benedict Anderson, popular politics is formed around shared, imaginary constructs rooted in our collective imagination. This book investigates these 'imagined sovereignties' in a genealogy traversing the French Enlightenment, the Haitian Revolution, and nineteenth-century Haitian constitutionalism. It problematizes taken-for-granted ideas about popular politics and provokes new ways of imagining the power of the people.
Numerical Analysis Using R
Authors: Griffiths Graham W.
Published: May 2016

This book presents the latest numerical solutions to initial value problems and boundary value problems described by ODEs and PDEs. The author offers practical methods that can be adapted to solve wide ranges of problems and illustrates them in the increasingly popular open source computer language R, allowing integration with more statistically based methods. The book begins with standard techniques, followed by an overview of 'high resolution' flux limiters and WENO to solve problems with solutions exhibiting high gradient phenomena. Meshless methods using radial basis functions are then discussed in the context of scattered data interpolation and the solution of PDEs on irregular grids. Three detailed case studies demonstrate how numerical methods can be used to tackle very different complex problems. With its focus on practical solutions to real-world problems, this book will be useful to students and practitioners in all areas of science and engineering, especially those using R.
Nine to Five
Authors: Grossman Joanna L.
Published: May 2016

Nine to Five provides a lively and accessible introduction to the laws and policies regulating sex, sexuality, and gender identity in the American workplace. Contemporary cases and events reveal the breadth and persistence of sexism and gender stereotyping. Through a series of essays organized around sex discrimination, sexual harassment, pregnancy discrimination, and pay equity, the book highlights legal rules and doctrines that privilege men over women and masculinity over femininity. In understanding the law - what it forbids, what it allows, and to what it turns a blind eye - we see why it is far too soon to declare the triumph of working women's equality. Despite significant gains for women, gender continues to define the work experience in both predictable and surprising ways. A witty and engaging guide to the legal terrain, Nine to Five also proposes solutions to the many obstacles that remain on the path to equality.
Schumann's Music and E. T. A. Hoffmann's Fiction
Authors: MacAuslan John
Published: May 2016

Four of Schumann's great masterpieces of the 1830s - Carnaval, Fantasiestücke, Kreisleriana and Nachtstücke - are connected to the fiction of E. T. A. Hoffmann. In this book, John MacAuslan traces Schumann's stylistic shifts during this period to offer insights into the expressive musical patterns that give shape, energy and individuality to each work. MacAuslan also relates the works to Schumann's reception of Bach, Beethoven, Novalis and Jean Paul, and focuses on primary sources in his wide-ranging discussion of the broader intellectual and aesthetic contexts. Uncovering lines of influence from Schumann's reading to his writings, and reflecting on how the aesthetic concepts involved might be used today, this book transforms the way Schumann's music and its literary connections can be understood and will be essential reading for musicologists, performers and listeners with an interest in Schumann, early nineteenth-century music and German Romantic culture.
New York State Public Health System Response to Hurricane Sandy: Lessons From the Field
Authors: Shipp Hilts Asante , Mack Stephanie , Eidson Millicent , Nguyen Trang , Birkhead Guthrie S.
Published: May 2016

Objective

The aim of this study was to conduct interviews with public health staff who responded to Hurricane Sandy and to analyze their feedback to assess response strengths and challenges and recommend improvements for future disaster preparedness and response.

Methods

Qualitative analysis was conducted of information from individual confidential interviews with 35 staff from 3 local health departments in New York State (NYS) impacted by Hurricane Sandy and the NYS Department of Health. Staff were asked about their experiences during Hurricane Sandy and their recommendations for improvements. Open coding was used to analyze interview transcripts for reoccurring themes, which were labeled as strengths, challenges, or recommendations and then categorized into public health preparedness capabilities.

Results

The most commonly cited strengths, challenges, and recommendations related to the Hurricane Sandy public health response in NYS were within the emergency operations coordination preparedness capability, which includes the abilities of health department staff to partner among government agencies, coordinate with emergency operation centers, conduct routine conference calls with partners, and manage resources.

Conclusions

Health departments should ensure that emergency planning includes protocols to coordinate backup staffing, delineation of services that can be halted during disasters, clear guidelines to coordinate resources across agencies, and training for transitioning into unfamiliar disaster response roles. (Disaster Med Public Health Preparedness. 2016;10:443–453)
Linear and nonlinear responses to harmonic force in rotating flow
Authors: Wei Xing
Published: May 2016

For understanding the dissipation in a rotating flow when resonance occurs, we study the rotating flow driven by the harmonic force in a periodic box. Both the linear and nonlinear regimes are studied. The various parameters such as the force amplitude $a$, the force frequency ${\it\omega}$, the force wavenumber $k$ and the Ekman number $E$ are investigated. In the linear regime, the dissipation at the resonant frequency scales as $E^{-1}k^{-2}$, and it is much stronger than the dissipation at the non-resonant frequencies on large scales and at low Ekman numbers. In the nonlinear regime, at the resonant frequency the effective dissipation (dissipation normalised with the square of the force amplitude) is lower than in the linear regime and it decreases with increasing force amplitude. This nonlinear suppression effect is significant near the resonant frequency but negligible far away from the resonant frequency. Opposite to the linear regime, in the nonlinear regime at the resonant frequency the lower Ekman number leads to lower dissipation because of the stronger nonlinear effect. This work implies that the previous linear calculations overestimated the tidal dissipation, which is important for understanding the tides in stars and giant planets.
Facing the Indigenous ‘Other’: Culturally Responsive Research and Pedagogy in Music Education
Authors: Locke Terry , Prentice Lauren
Published: May 2016

This narrative article is based on an analysis of 61 documents, mostly articles, of which 37 were peer-reviewed, including research studies, reviews, conceptual research and narratives of practice. Review findings are reported with specific reference to the Australian and New Zealand contexts in relation to the following topic categories: the presence of indigenous music in the curriculums of selected ‘new world’ countries, teacher education in indigenous performing arts, questions of curriculum design and programming, resource selection, activity design, and school and community relationships. Certain key themes emerged across these topics: the need for a greater emphasis on more culturally nuanced music teacher education in relation to indigenous musics; the critical importance of teaching indigenous music/arts contexts; song ownership; and the need for music educators and researchers to develop a critical stance towards their subject and discipline.
Adam Smith on What Is Wrong with Economic Inequality
Authors: RASMUSSEN DENNIS C.
Published: May 2016

This article explores Adam Smith's attitude toward economic inequality, as distinct from the problem of poverty, and argues that he regarded it as a double-edged sword. On the one hand, as has often been recognized, Smith saw a high degree of economic inequality as an inevitable result of a flourishing commercial society, and he considered a certain amount of such inequality to be positively useful as a means of encouraging productivity and bolstering political stability. On the other hand, it has seldom been noticed that Smith also expressed deep worries about some of the other effects of extreme economic inequality—worries that are, moreover, interestingly different from those that dominate contemporary discourse. In Smith's view, extreme economic inequality leads people to sympathize more fully and readily with the rich than the poor, and this distortion in our sympathies in turn undermines both morality and happiness.
Resonance methods for the characterization of dust particles in plasmas
Authors: Jung Hendrik , Greiner Franko , Asnaz Oguz Han , Carstensen Jan , Piel Alexander
Published: May 2016

The fundamentals of the ‘resonance method’ are presented. The method relies on evaluating the dynamic response of one or more dust particles in the sheath of a laboratory plasma to small external perturbations. It allows one to make in situ high-precision measurements of particle properties. It is shown that the particle mass and charge and the strength of the interaction between two particles can be measured. Technical requirements, limitations and application examples are presented and discussed.
Gyrokinetic stability theory of electron–positron plasmas
Authors: Helander P. , Connor J. W.
Published: May 2016

The linear gyrokinetic stability properties of magnetically confined electron–positron plasmas are investigated in the parameter regime most likely to be relevant for the first laboratory experiments involving such plasmas, where the density is small enough that collisions can be ignored and the Debye length substantially exceeds the gyroradius. Although the plasma beta is very small, electromagnetic effects are retained, but magnetic compressibility can be neglected. The work of a previous publication (Helander, Phys. Rev. Lett., vol. 113, 2014a, 135003) is thus extended to include electromagnetic instabilities, which are of importance in closed-field-line configurations, where such instabilities can occur at arbitrarily low pressure. It is found that gyrokinetic instabilities are completely absent if the magnetic field is homogeneous: any instability must involve magnetic curvature or shear. Furthermore, in dipole magnetic fields, the stability threshold for interchange modes with wavelengths exceeding the Debye radius coincides with that in ideal magnetohydrodynamics. Above this threshold, the quasilinear particle flux is directed inward if the temperature gradient is sufficiently large, leading to spontaneous peaking of the density profile.
Reading between the words: The effect of literacy on second language lexical segmentation
Authors: HAVRON NAOMI , ARNON INBAL
Published: May 2016

There is evidence that the ability to segment an utterance into words improves with literacy, yet previous research makes it difficult to disentangle the effect of literacy from that of age or cognitive abilities. We tested the hypothesis that literacy increases lexical segmentation in a second language in a unique sample of adult illiterates learning to read in their second language, controlling for cognitive abilities and using a task that taps language processing rather than only metalinguistic awareness. Participants’ segmentation was correlated with first language reading at the beginning of an intensive literacy course for illiterate adults. At the end of the course, those learning to read for the first time benefited more in terms of their segmentation abilities. We discuss implications for models of second language learning.
The relation of maternal literate mediation strategies and socioemotional comments to Korean children's Hangul reading
Authors: CHO JEUNG-RYEUL , McBRIDE CATHERINE , LIN DAN
Published: May 2016

The present study examined Korean mothers’ literate mediation strategies and socioemotional supports for 84 4- and 5-year-old children as they wrote unfamiliar words, and the relation of these strategies and comments to Korean children's Hangul reading. The mother–child writing interactions were videotaped. Eight strategies of maternal literate mediation were subsequently identified and five socioemotional comments were coded. Mothers of 5-year-olds used a coda-focused (i.e., emphasis on the final consonant of a syllable) strategy more often than those of 4-year-olds. The maternal coda focus was uniquely associated with children's word reading over and above mothers’ education and children's age, grade, vocabulary, and writing skill. Maternal literate mediation focused on the consonant–vowel (CV) subsyllabic unit, which explained children's reading of CV Gulja (Korean written syllable). These results suggest that efficient maternal literate mediation strategies focus on salient psycholinguistic grain size of Korean language such as CV (body) and coda subsyllabic units. In addition, the two socioemotional categories of process and critical comments were uniquely associated with children's reading. Findings underscore the importance of Korean language and culture in mothers’ early scaffolding to facilitate children's literacy acquisition.
Planning, traffic and the city: railway development in colonial Delhi,c.1899–1905
Authors: KISHORE RAGHAV
Published: May 2016

This article examines how the management of railway traffic was problematized in urban plans for colonial Delhi after the 1890s. It reveals how Delhi was reconstituted as a space of circulation in municipal plans attempting to combat railway-induced ‘traffic congestion’. Yet, even as new gardens, localities and footpaths were envisaged as enabling smooth flows of traffic and generating a commercially healthy city, policing anxieties and concerns over political security dominated in such plans. Finally, this article shows how the process of railway-inspired ‘urban planning’ was itself driven by a contestation between different ‘scales’ of the colonial state.
Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses
Authors: Cunin P , Beauvillain C , Miot C , Augusto J-F , Preisser L , Blanchard S , Pignon P , Scotet M , Garo E , Fremaux I , Chevailler A , Subra J-F , Blanco P , Wilson M R , Jeannin P , Delneste Y
Published: May 2016

Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both in vitro and in vivo, the phagocytosis of late apoptotic cells by macrophages. Moreover, the increased phagocytosis of late apoptotic cells induced by Clu favors the presentation and cross-presentation of apoptotic cell-associated antigens. Finally, we observed that, in a model of apoptotic cell-induced autoimmunity, and relative to control mice, Clu−/− mice develop symptoms of autoimmunity, including the generation of anti-dsDNA antibodies, deposition of immunoglobulins and complement components within kidneys, and splenomegaly. These results identify Clu as a new molecule partner involved in apoptotic cell efferocytosis and suggest a protective role for Clu in inflammation and autoimmune diseases.
miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
Authors: Xu Shaohua , Tao Zhen , Hai Bo , Liang Huagen , Shi Ying , Wang Tao , Song Wen , Chen Yong , OuYang Jun , Chen Jinhong , Kong Fanfei , Dong Yishan , Jiang Shi-Wen , Li Weiyong , Wang Ping , Yuan Zhiyong , Wan Xiaoping , Wang Chenguang , Li Wencheng , Zhang Xiaoping , Chen Ke
Published: May 2016

Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers. Here we demonstrate that miR-424(322) regulates the PD-L1/PD-1 and CD80/CTLA-4 pathways in chemoresistant ovarian cancer. miR-424(322) is inversely correlated with PD-L1, PD-1, CD80 and CTLA-4 expression. High levels of miR-424(322) in the tumours are positively correlated with the progression-free survival of ovarian cancer patients. Mechanistic investigations demonstrated that miR-424(322) inhibited PD-L1 and CD80 expression through direct binding to the 3′-untranslated region. Restoration of miR-424(322) expression reverses chemoresistance, which is accompanied by blockage of the PD-L1 immune checkpoint. The synergistic effect of chemotherapy and immunotherapy is associated with the proliferation of functional cytotoxic CD8+ T cells and the inhibition of myeloid-derived suppressive cells and regulatory T cells. Collectively, our data suggest a biological and functional interaction between PD-L1 and chemoresistance through the microRNA regulatory cascade.
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility
Authors: Wang Meilin , Gu Dongying , Du Mulong , Xu Zhi , Zhang Suzhan , Zhu Lingjun , Lu Jiachun , Zhang Rui , Xing Jinliang , Miao Xiaoping , Chu Haiyan , Hu Zhibin , Yang Lei , Tang Cuiju , Pan Lei , Du Haina , Zhao Jian , Du Jiangbo , Tong Na , Sun Jielin , Shen Hongbing , Xu Jianfeng , Zhang Zhengdong , Chen Jinfei
Published: May 2016

Genome-wide association studies (GWASs) have identified multiple susceptibility loci for colorectal cancer, but much of heritability remains unexplained. To identify additional susceptibility loci for colorectal cancer, here we perform a GWAS in 1,023 cases and 1,306 controls and replicate the findings in seven independent samples from China, comprising 5,317 cases and 6,887 controls. We find a variant at 12p13.2 associated with colorectal cancer risk (rs2238126 in ETV6, P=2.67 × 10−10). We replicate this association in an additional 1,046 cases and 1,076 controls of European ancestry (P=0.034). The G allele of rs2238126 confers earlier age at onset of colorectal cancer (P=1.98 × 10−6) and reduces the binding affinity of transcriptional enhancer MAX. The mRNA level of ETV6 is significantly lower in colorectal tumours than in paired normal tissues. Our findings highlight the potential importance of genetic variation in ETV6 conferring susceptibility to colorectal cancer.
Efficient quantum walk on a quantum processor
Authors: Qiang Xiaogang , Loke Thomas , Montanaro Ashley , Aungskunsiri Kanin , Zhou Xiaoqi , O’Brien Jeremy L. , Wang Jingbo B. , Matthews Jonathan C. F.
Published: May 2016

The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. We also show that solving the same sampling problem for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectures from computational complexity theory. This is a new link between continuous-time quantum walks and computational complexity theory and it indicates a family of tasks that could ultimately demonstrate quantum supremacy over classical computers. As a proof of principle, we experimentally implement the proposed quantum circuit on an example circulant graph using a two-qubit photonics quantum processor.
Autonomous self-healing structural composites with bio-inspired design
Authors: D’Elia Eleonora , Eslava Salvador , Miranda Miriam , Georgiou Theoni K. , Saiz Eduardo
Published: May 2016

Strong and tough natural composites such as bone, silk or nacre are often built from stiff blocks bound together using thin interfacial soft layers that can also provide sacrificial bonds for self-repair. Here we show that it is possible exploit this design in order to create self-healing structural composites by using thin supramolecular polymer interfaces between ceramic blocks. We have built model brick-and-mortar structures with ceramic contents above 95 vol% that exhibit strengths of the order of MPa (three orders of magnitude higher than the interfacial polymer) and fracture energies that are two orders of magnitude higher than those of the glass bricks. More importantly, these properties can be fully recovered after fracture without using external stimuli or delivering healing agents. This approach demonstrates a very promising route towards the design of strong, ideal self-healing materials able to self-repair repeatedly without degradation or external stimuli.
Learning Bayesian Networks from Correlated Data
Authors: Bae Harold , Monti Stefano , Montano Monty , Steinberg Martin H. , Perls Thomas T. , Sebastiani Paola
Published: May 2016

Bayesian networks are probabilistic models that represent complex distributions in a modular way and have become very popular in many fields. There are many methods to build Bayesian networks from a random sample of independent and identically distributed observations. However, many observational studies are designed using some form of clustered sampling that introduces correlations between observations within the same cluster and ignoring this correlation typically inflates the rate of false positive associations. We describe a novel parameterization of Bayesian networks that uses random effects to model the correlation within sample units and can be used for structure and parameter learning from correlated data without inflating the Type I error rate. We compare different learning metrics using simulations and illustrate the method in two real examples: an analysis of genetic and non-genetic factors associated with human longevity from a family-based study and an example of risk factors for complications of sickle cell anemia from a longitudinal study with repeated measures.
Multi-scale analysis of relationship between landscape pattern and urban river water quality in different seasons
Authors: Xiao Rui , Wang Guofeng , Zhang Qianwen , Zhang Zhonghao
Published: May 2016

Water quality is highly dependent on the landscape characteristics. In this study, we investigated the relationships between water quality and landscape pattern (composition and configuration) in Huzhou City, China. The water quality variables, including pH, dissolved oxygen (DO), chemical oxygen demand (CODMn), Biochemical Oxygen Demand (BOD), NH3-N, petroleum, dissolved total phosphorus (DTP), and total nitrogen (TN) in low water, normal water and flood periods were identified by investigating 34 sampling sites in Huzhou City during the period from 2001 to 2007. Landscape composition and landscape configuration metrics were calculated for different scales. It was found that scales and seasons both play important role when analyzing the relationships between landscape characteristics of different land use types. The results implied that some water quality parameters such as CODMn, petroleum are more polluted in flood period than the other two seasons at different scales, while DTP and TN are more polluted in low water period. Influences of different landscape metrics on water quality should operate at different spatial scales. The results shown in this paper will effectively provide scientific basis for the policy making in sustainable development of water environment.
Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models
Authors: Hong Chien Tai , Chau Kai-Yin , Schapira Anthony H. V.
Published: May 2016

Meclizine is a well-tolerated drug routinely used as an anti-histamine agent in the management of disequilibrium. Recently, meclizine has been assessed for its neuroprotective properties in ischemic stroke and Huntington disease models. We found that meclizine protected against 6-hydroxydopamine-induced apoptosis and cell death in both SH-SY5Y cells and rat primary cortical cultures. Meclizine increases the level of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which activates phosphofructokinase, a rate-determining enzyme of glycolysis. This protection is therefore mediated by meclizine’s ability to enhance glycolysis and increase mitochondrial hyperpolarization. Meclizine represents an interesting candidate for further investigation to re-purpose for its potential to be neuroprotective in Parkinson disease.
New long-proboscid lacewings of the mid-Cretaceous provide insights into ancient plant-pollinator interactions
Authors: Lu Xiu-Mei , Zhang Wei-Wei , Liu Xing-Yue
Published: May 2016

Many insects with long-proboscid mouthparts are among the pollinators of seed plants. Several cases of the long-proboscid pollination mode are known between fossil insects (e.g., true flies, scorpionflies and lacewings) and various extinct gymnosperm lineages, beginning in the Early Permian and increasing during the Middle Jurassic to Early Cretaceous. However, details on the morphology of lacewing proboscides and the relevant pollination habit are largely lacking. Here we report on three lacewing species that belong to two new genera and a described genus from mid-Cretaceous (Albian-Cenomanian) amber of Myanmar. All these species possess relatively long proboscides, which are considered to be modified from maxillary and labial elements, probably functioning as a temporary siphon for feeding on nectar. Remarkably, these proboscides range from 0.4–1.0 mm in length and are attributed to the most diminutive ones among the contemporary long-proboscid insect pollinators. Further, they clearly differ from other long-proboscid lacewings which have a much longer siphon. The phylogenetic analysis indicates that these Burmese long-proboscid lacewings belong to the superfamily Psychopsoidea but cannot be placed into any known family. The present findings represent the first description of the mouthparts of long-proboscid lacewings preserved in amber and highlight the evolutionary diversification of the ancient plant-pollinator interactions.
Ectopic expression of amaranth seed storage albumin modulates photoassimilate transport and nutrient acquisition in sweetpotato
Authors: Shekhar Shubhendu , Agrawal Lalit , Mishra Divya , Buragohain Alak Kumar , Unnikrishnan Mullath , Mohan Chokkappan , Chakraborty Subhra , Chakraborty Niranjan
Published: May 2016

Storage proteins in plants, because of high nutrient value, have been a subject of intensive investigation. These proteins are synthesized de novo in the cytoplasm and transported to the storage organelles where they serve as reservoir of energy and supplement of nitrogen during rapid growth and development. Sweetpotato is the seventh most important food crop worldwide and has a significant contribution to the source of nutrition, albeit with low protein content. To determine the behaviour of seed storage proteins in non-native system, a seed albumin, AmA1, was overexpressed in sweetpotato with an additional aim of improving nutritional quality of tuber proteins. Introduction of AmA1 imparted an increase in protein and amino acid contents as well as the phytophenols. The proteometabolomics analysis revealed a rebalancing of the proteome, with no significant effects on the global metabolome profile of the transgenic tubers. Additionally, the slower degradation of starch and cellulose in transgenic tubers, led to increased post-harvest durability. Present study provides a new insight into the role of a seed storage protein in the modulation of photoassimilate movement and nutrient acquisition.
Detection of Epileptic Seizures Using Phase–Amplitude Coupling in Intracranial Electroencephalography
Authors: Edakawa Kohtaroh , Yanagisawa Takufumi , Kishima Haruhiko , Fukuma Ryohei , Oshino Satoru , Khoo Hui Ming , Kobayashi Maki , Tanaka Masataka , Yoshimine Toshiki
Published: May 2016

Seizure detection using intracranial electroencephalography (iEEG) contributes to improved treatment of patients with refractory epilepsy. For that purpose, a feature of iEEG to characterize the ictal state with high specificity and sensitivity is necessary. We evaluated the use of phase–amplitude coupling (PAC) of iEEG signals over a period of 24 h to detect the ictal and interictal states. PAC was estimated by using a synchronisation index (SI) for iEEG signals from seven patients with refractory temporal lobe epilepsy. iEEG signals of the ictal state was characterised by a strong PAC between the phase of β and the amplitude of high γ. Furthermore, using SI values, the ictal state was successfully detected with significantly higher accuracy than by using the amplitude of high γ alone. In conclusion, PAC accurately distinguished the ictal state from the interictal state.
Presence of Li Clusters in Molten LiCl-Li
Authors: Merwin Augustus , Phillips William C. , Williamson Mark A. , Willit James L. , Motsegood Perry N. , Chidambaram Dev
Published: May 2016

Molten mixtures of lithium chloride and metallic lithium are of significant interest in various metal oxide reduction processes. These solutions have been reported to exhibit seemingly anomalous physical characteristics that lack a comprehensive explanation. In the current work, the physical chemistry of molten solutions of lithium chloride and metallic lithium, with and without lithium oxide, was investigated using in situ Raman spectroscopy. The Raman spectra obtained from these solutions were in agreement with the previously reported spectrum of the lithium cluster, Li8. This observation is indicative of a nanofluid type colloidal suspension of Li8 in a molten salt matrix. It is suggested that the formation and suspension of lithium clusters in lithium chloride is the cause of various phenomena exhibited by these solutions that were previously unexplainable.
Flagellin-induced NADPH oxidase 4 activation is involved in atherosclerosis
Authors: Kim Jinoh , Seo Misun , Kim Su Kyung , Bae Yun Soo
Published: May 2016

It is widely accepted that bacterial infection-mediated inflammation facilitates development of atherosclerosis by activating toll-like receptor (TLR) signaling system. We reasoned that NADPH oxidases (Nox), required for TLR-mediated inflammatory response, are involved in atherogenesis. Here, we show that the activation of Nox4 through TLR5 regulates the inflammation of the endothelium and in atherogenesis. Flagellin-induced interaction between the COOH region of Nox4 and the TIR domain of TLR5 led to H2O2 generation, which in turn promoted the secretion of pro-inflammatory cytokines including IL-8, as well as the expression of ICAM-1 in human aortic endothelial cells (HAECs). Knockdown of the Nox4 in HAECs resulted in attenuated expressions of IL-8 and ICAM-1 leading to a reduction in the adhesion and trans-endothelial migration of monocytes. Challenge of recombinant FliC (rFliC) to the ApoE KO mice with high-fat diet (HFD) resulted in significantly increased atherosclerotic plaque sizes compared to the saline-injected mice. However, an injection of rFliC into the Nox4ApoE DKO mice with HFDs failed to generate atherosclerotic plaque, suggesting that Nox4 deficiency resulted in significant protections against rFliC-mediated atherogenesis. We conclude that TLR5-dependent Nox4 activation and subsequent H2O2 generation play critical roles for the development of atherosclerosis.