bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning
Authors: Holbrook Matthew D. , Clark Darin P. , Patel Rutulkumar , Qi Yi , Bassil Alex M. , Mowery Yvonne M. , Badea Cristian T.
Published: August 2021

We are developing imaging methods for a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform longitudinal micro-computed tomography (micro-CT) of mice to detect lung metastasis after treatment. This work explores deep learning (DL) as a fast approach for automated lung nodule detection. We used data from control mice both with and without primary lung tumors. To augment the number of training sets, we have simulated data using real augmented tumors inserted into micro-CT scans. We employed a convolutional neural network (CNN), trained with four competing types of training data: (1) simulated only, (2) real only, (3) simulated and real, and (4) pretraining on simulated followed with real data. We evaluated our model performance using precision and recall curves, as well as receiver operating curves (ROC) and their area under the curve (AUC). The AUC appears to be almost identical (0.76–0.77) for all four cases. However, the combination of real and synthetic data was shown to improve precision by 8%. Smaller tumors have lower rates of detection than larger ones, with networks trained on real data showing better performance. Our work suggests that DL is a promising approach for fast and relatively accurate detection of lung tumors in mice.
The Dragon’s Paralysing Spell: Evidence of Sodium and Calcium Ion Channel Binding Neurotoxins in Helodermatid and Varanid Lizard Venoms
Authors: Dobson James S. , Harris Richard J. , Zdenek Christina N. , Huynh Tam , Hodgson Wayne C. , Bosmans Frank , Fourmy Rudy , Violette Aude , Fry Bryan G.
Published: August 2021

Bites from helodermatid lizards can cause pain, paresthesia, paralysis, and tachycardia, as well as other symptoms consistent with neurotoxicity. Furthermore, in vitro studies have shown that Heloderma horridum venom inhibits ion flux and blocks the electrical stimulation of skeletal muscles. Helodermatids have long been considered the only venomous lizards, but a large body of robust evidence has demonstrated venom to be a basal trait of Anguimorpha. This clade includes varanid lizards, whose bites have been reported to cause anticoagulation, pain, and occasionally paralysis and tachycardia. Despite the evolutionary novelty of these lizard venoms, their neuromuscular targets have yet to be identified, even for the iconic helodermatid lizards. Therefore, to fill this knowledge gap, the venoms of three Heloderma species (H. exasperatum, H. horridum and H. suspectum) and two Varanus species (V. salvadorii and V. varius) were investigated using Gallus gallus chick biventer cervicis nerve–muscle preparations and biolayer interferometry assays for binding to mammalian ion channels. Incubation with Heloderma venoms caused the reduction in nerve-mediated muscle twitches post initial response of avian skeletal muscle tissue preparation assays suggesting voltage-gated sodium (NaV) channel binding. Congruent with the flaccid paralysis inducing blockage of electrical stimulation in the skeletal muscle preparations, the biolayer interferometry tests with Heloderma suspectum venom revealed binding to the S3–S4 loop within voltage-sensing domain IV of the skeletal muscle channel subtype, NaV1.4. Consistent with tachycardia reported in clinical cases, the venom also bound to voltage-sensing domain IV of the cardiac smooth muscle calcium channel, CaV1.2. While Varanus varius venom did not have discernable effects in the avian tissue preparation assay at the concentration tested, in the biointerferometry assay both V. varius and V. salvadorii bound to voltage-sensing domain IV of both NaV1.4 and CaV1.2, similar to H. suspectum venom. The ability of varanid venoms to bind to mammalian ion channels but not to the avian tissue preparation suggests prey-selective actions, as did the differential potency within the Heloderma venoms for avian versus mammalian pathophysiological targets. This study thus presents the detailed characterization of Heloderma venom ion channel neurotoxicity and offers the first evidence of varanid lizard venom neurotoxicity. In addition, the data not only provide information useful to understanding the clinical effects produced by envenomations, but also reveal their utility as physiological probes, and underscore the potential utility of neglected venomous lineages in the drug design and development pipeline.
Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses
Authors: Welker Lisa , Paillart Jean-Christophe , Bernacchi Serena
Published: August 2021

Late assembly (L) domains are conserved sequences that are necessary for the late steps of viral replication, acting like cellular adaptors to engage the ESCRT membrane fission machinery that promote virion release. These short sequences, whose mutation or deletion produce the accumulation of immature virions at the plasma membrane, were firstly identified within retroviral Gag precursors, and in a further step, also in structural proteins of many other enveloped RNA viruses including arenaviruses, filoviruses, rhabdoviruses, reoviruses, and paramyxoviruses. Three classes of L domains have been identified thus far (PT/SAP, YPXnL/LXXLF, and PPxY), even if it has recently been suggested that other motifs could act as L domains. Here, we summarize the current state of knowledge of the different types of L domains and their cellular partners in the budding events of RNA viruses, with a particular focus on retroviruses.
Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters
Authors: Bleasby Kelly , Houle Robert , Hafey Michael , Lin Meihong , Guo Jingjing , Lu Bing , Sanchez Rosa I. , Fillgrove Kerry L.
Published: August 2021

Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro. Elimination of islatravir is expected to be balanced between adenosine deaminase–mediated metabolism and renal excretion. Islatravir did not inhibit uridine diphosphate glucuronosyltransferase 1A1 or cytochrome p450 (CYP) enzymes CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, or 3A4, nor did it induce CYP1A2, 2B6, or 3A4. Islatravir did not inhibit hepatic transporters organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter (OCT) 1, bile salt export pump (BSEP), multidrug resistance-associated protein (MRP) 2, MRP3, or MRP4. Islatravir was neither a substrate nor a significant inhibitor of renal transporters organic anion transporter (OAT) 1, OAT3, OCT2, multidrug and toxin extrusion protein (MATE) 1, or MATE2K. Islatravir did not significantly inhibit P-glycoprotein and breast cancer resistance protein (BCRP); however, it was a substrate of BCRP, which is not expected to be of clinical significance. These findings suggest islatravir is unlikely to be the victim or perpetrator of drug-drug interactions with commonly co-prescribed medications, including statins, diuretics, anti-diabetic drugs, proton pump inhibitors, anticoagulants, benzodiazepines, and selective serotonin reuptake inhibitors.
Hesitant or Not Hesitant? A Systematic Review on Global COVID-19 Vaccine Acceptance in Different Populations
Authors: Salomoni Maria Giulia , Di Valerio Zeno , Gabrielli Elisa , Montalti Marco , Tedesco Dario , Guaraldi Federica , Gori Davide
Published: August 2021

Vaccination currently appears to be the only strategy to contain the spread of COVID-19. At the same time, vaccine hesitancy (VH) could limit its efficacy and has, therefore, attracted the attention of Public Health Systems. This systematic review aimed at assessing anti-COVID-19 vaccine acceptance rates worldwide and at identifying populations more prone to vaccine hesitancy, for which specific interventions should be planned. PubMed database was searched using a purposely formulated string. One hundred out of the 9243 studies retrieved were considered pertinent and thus included in the analyses. VH rate was analyzed according to patient geographical origin, ethnicity, age, study setting, and method used for data collection; data from specific populations were separately analyzed. Overall, this study demonstrated significant differences in terms of VH in the general population and in the specific subgroups examined according to geographical, demographic factors, as well as associated comorbidities, underlining the need for purposely designed studies in specific populations from the different countries, to design targeted programs aimed at increasing awareness for confidence and complacency toward COVID-19 vaccines.
DNA Vaccine Administered by Cationic Lipoplexes or by In Vivo Electroporation Induces Comparable Antibody Responses against SARS-CoV-2 in Mice
Authors: Peletta Allegra , Prompetchara Eakachai , Tharakhet Kittipan , Kaewpang Papatsara , Buranapraditkun Supranee , Techawiwattanaboon Teerasit , Jbilou Tayeb , Krangvichian Pratomporn , Sirivichayakul Sunee , Manopwisedjaroen Suwimon , Thitithanyanont Arunee , Patarakul Kanitha , Ruxrungtham Kiat , Ketloy Chutitorn , Borchard Gerrit
Published: August 2021

In view of addressing the global necessity of an effective vaccine in the SARS-CoV-2 pandemic, a plasmid DNA vaccine, expressing for the spike (S) protein and formulated in lipoplexes, was manufactured and tested for in vitro transfection and in vivo immunogenicity. Blank cationic liposomes of 130.9 ± 5.8 nm in size and with a zeta potential of +48 ± 12 mV were formulated using the thin-film layer rehydration method. Liposomes were complexed with pCMVkan-S at different N/P ratios. Ratios of 0.25:1 and 1:1 were selected according to their complex stability and controlled size compared to other ratios and tested in vitro for transfection studies and in vivo for immunogenicity. Both selected formulations showed enhanced neutralizing antibody responses compared to pCMVkan-S injected alone, as well as an increased T cell response. The titers observed were similar to those of intramuscular electroporation (IM-EP), which was set as an efficacy goal.
Correlates of COVID-19 Vaccine Hesitancy among a Community Sample of African Americans Living in the Southern United States
Authors: Moore Justin Xavier , Gilbert Keon L. , Lively Katie L. , Laurent Christian , Chawla Rishab , Li Cynthia , Johnson Ryan , Petcu Robert , Mehra Mehul , Spooner Antron , Kolhe Ravindra , Ledford Christy J. W.
Published: August 2021

In the United States, African Americans (AAs) have been disproportionately affected by COVID-19 mortality. However, AAs are more likely to be hesitant in receiving COVID-19 vaccinations when compared to non-Hispanic Whites. We examined factors associated with vaccine hesitancy among a predominant AA community sample. We performed a cross-sectional analysis on data collected from a convenience sample of 257 community-dwelling participants in the Central Savannah River Area from 5 December 2020, through 17 April 2021. Vaccine hesitancy was categorized as resistant, hesitant, and acceptant. We estimated relative odds of vaccine resistance and vaccine hesitancy using polytomous logistic regression models. Nearly one-third of the participants were either hesitant (n = 40, 15.6%) or resistant (n = 42, 16.3%) to receiving a COVID-19 vaccination. Vaccine-resistant participants were more likely to be younger and were more likely to have experienced housing insecurity due to COVID-19 when compared to both acceptant and hesitant participants, respectively. Age accounted for nearly 25% of the variation in vaccine resistance, with 21-fold increased odds (OR: 21.93, 95% CI: 8.97–5.26–91.43) of vaccine resistance in participants aged 18 to 29 compared to 50 and older adults. Housing insecurity accounted for 8% of the variation in vaccine resistance and was associated with 7-fold increased odds of vaccine resistance (AOR: 7.35, 95% CI: 1.99–27.10). In this sample, AAs under the age of 30 and those experiencing housing insecurity because of the COVID-19 pandemic were more likely to be resistant to receiving a free COVID-19 vaccination.
Physics-Based and Data-Enhanced Model for Electric Drive Sizing during System Design of Electrified Powertrains
Authors: Decker Lukas , Förster Daniel , Gauterin Frank , Doppelbauer Martin
Published: August 2021

In multi-drive electrified powertrains, the control strategy strongly influences the component load collectives. Due to this interdependency, the component sizing becomes a difficult task. This paper comprehensively analyses different electric drive system sizing methods for multi-drive systems in the literature. Based on this analysis, a new data-enhanced sizing approach is proposed. While the characteristic is depicted with a physics-based polynomial model, a data-enhanced limiting function ensures the parameter variation stays within a physically feasible range. Its beneficial value is demonstrated by applying the new model to a powertrain system optimization. The new approach enables a detailed investigation of the correlations between the characteristic of electric drive systems and the overall vehicle energy consumption for varying topologies. The application results demonstrate the accuracy and benefit of the proposed model.
First Record of Colonial Ascidian, Botrylloides diegensis Ritter and Forsyth, 1917 (Ascidiacea, Stolidobranchia, Styelidae), in South Korea
Authors: Lee Taekjun , Shin Sook
Published: August 2021

Botrylloides species are important members of the fouling community colonizing artificial substrates in harbors and marinas. During monitoring in 2017–2020 of non-indigenous species in Korea, one colonial ascidian species was distinctly different from other native colonial ascidians, such as B. violaceus and Botryllus schlosseri, in South Korea. This species was identified as B. diegensis. DNA barcodes with mitochondrial COI were used to identify one-toned and two-toned colonies of B. diegensis. Intraspecific variations between Korean and other regions of B. diegensis from the NCBI ranged from 0.0% to 1.3%. The Korean B. diegensis was clearly distinct from other species of Botrylloides at 15.8–24.2%. In phylogenetic analysis results, Korean B. diegensis was established as a single clade with other regions of B. diegensis and was clearly distinct from Korean B. violaceus. After reviewing previous monitoring data, it was found that two-toned B. diegensis was already found in six harbors by July 2017. It has now spread into 14 harbors along the coastal line of South Korea. This means that B. diegensis might have been introduced to South Korea between 1999 and 2016.
Effects of Habitat Restoration on Fish Communities in Urban Streams
Authors: Lavelle Anna M. , Chadwick Michael A. , Chadwick Daniel D. A. , Pritchard Eleri G. , Bury Nicolas R.
Published: August 2021

Geomorphological alterations, hydrological disconnectivity and water pollution are among the dominant pressures affecting ecological integrity in urban streams. River restoration approaches often involve utilising in-stream structures to encourage flow heterogeneity and promote habitat diversity. However, few studies examine the success of such projects. In this study, fish density, biomass and community structure at paired restored and unrestored reaches across five tributaries of the River Thames were examined. Fish density varied among rivers and reaches but was generally higher at restored sites. Restored sites also exhibited higher overall fish biomass, attributed mainly to the presence of brown trout (Salmo trutta L.) at the River Wandle. Despite higher density and biomass values at restored sites, the community structure analysis did not identify strong links between either river or restoration status using either species-specific density or biomass. Our results highlight that although reach-scale restoration can lead to localised increases in species density and biomass, this may chiefly be due to aggregation owing to preferential habitats created through restoration activities at these sites. Over larger spatial scales, significant improvements to species richness and diversity are likely to be limited due to the poor water quality and disconnected nature of these urban streams. Whilst reach-scale restoration clearly has the potential to provide preferential habitats for fish species, future efforts should focus on improving connectivity for fish across the wider Thames basin network by removing barriers to passage, improving water quality, restoring watershed processes and creating well-connected, diverse habitats which can facilitate the survival of a wide array of fish species throughout their life cycle.
Assessment of Different Pressure Drop-Flow Rate Equations in a Pressurized Porous Media Filter for Irrigation Systems
Authors: Graciano-Uribe Jonathan , Pujol Toni , Puig-Bargués Jaume , Duran-Ros Miquel , Arbat Gerard , Ramírez de Cartagena Francisco
Published: August 2021

The small open area available at the slots of underdrains in pressurized granular bed filters for drip irrigation implies: (1) the existence of a region with non-uniform flow, and (2) local values of modified particle Reynolds number >500. These flow conditions may disagree with those accepted as valid for common pressure drop-flow rate correlations proposed for packed beds. Here, we carried out detailed computational fluid dynamics (CFD) simulations of a laboratory filter to analyze the results obtained with five different equations of head losses in porous media: (1) Ergun, (2) Darcy-Forchheimer, (3) Darcy, (4) Kozeny-Carman and (5) power function. Simulations were compared with experimental data at different superficial velocities obtained from previous studies. Results for two silica sand media indicated that all equations predicted total filter pressure drop values within the experimental uncertainty range when superficial velocities <38.3 m h−1. At higher flow rates, Ergun equation approximated the best to the observed results for silica sand media, being the expression recommended. A simple analytical model of the pressure drop along flow streamlines that matched CFD simulation results was developed.
Investigation of Inlet Gas Relative Humidity on Performance Characteristics of PEMFC Operating at Elevated Temperature
Authors: Xu Yiming , Chang Guofeng , Zhang Jienan , Li Yuyang , Xu Sichuan
Published: August 2021

Raising the operating temperature is considered to be an effective method to improve the output performance of proton exchange membrane fuel cells (PEMFCs). In this paper, the effects of inlet relative humidity in the anode (RHa) and cathode (RHc) on the polarization curve and impedance spectra of a single rotating serpentine PEMFC were investigated by experimental method at the operating temperature of 90 °C. It was found that the output performance is the smallest in the high RH case (RHa90%/RHc90%) due to the largest mass transfer resistance. However, the ohmic resistance in the dry case (RHa50%/RHc50%) is the highest, and it shows better output performance at more than 1.0 A/cm2 because of the lowest mass transfer resistance. The impact of the changes in the RHa value on the polarization curve is more apparent than that of the RHc changes at high current density. The largest power density can be attained and the efficiency can reach 24.4% when the RHa is 90% and RHc is 50%.
Three-Dimensional Pelvic Floor Ultrasound Assessment of Pelvic Organ Prolapse: Minimal Levator Hiatus and Levator Ani Deficiency Score
Authors: Yune Yongwoo , Jeong Hong Yoon , Park Duk Hoon , Lee Jong Kyun
Published: August 2021

Purpose: The purpose of this study was to determine whether levator ani deficiency (LAD) scores and minimal levator hiatus (MLH) areas affect Pelvic Organ Prolapse Quantification (POP-Q) stage.Methods: This study was a retrospective chart review of patients with pelvic organ prolapse (POP) at Seoul Songdo Hospital between August 2019 and August 2020. Three-dimensional (3D) pelvic floor ultrasound, preoperative anal manometry, and other physiological tests were performed in 78 patients with POP symptoms. We divided the patients into mild prolapse and severe prolapse groups based on the POP-Q. We examined the LAD and MLH areas. LAD scores were categorized as mild, moderate, or severe.Results: There were 32 patients (41.0%) in the mild prolapse group (POP-Q stage I and II) and 46 (59.0%) in the severe prolapse group (POP-Q stage III and IV). The mean LAD score was significantly higher in severe prolapse group (13.33±2.49 vs. 8.19±2.92, P<0.001), and the rate of severe deficiency was also significantly higher in the severe prolapse group (29 [63.0%] vs. 2 [6.3%], P<0.001). The mean MLH was also significantly larger in the severe prolapse group (17.91±2.74 cm2 vs. 14.95±2.60 cm2, P<0.001). In addition, both MLH and LAD scores tended to increase at each stage.Conclusion: There is a strong positive correlation between the POP-Q stage and the MLH and LAD scores that can be seen on 3D pelvic floor ultrasound. The findings of this study, by objectively demonstrating LAD and MLH in women with POP, are an important contribution to POP.
Has the COVID-19 Pandemic Caused Upshifting in Colorectal Cancer Stage?
Authors: Lim Ji Ha , Lee Woo Yong , Yun Seong Hyeon , Kim Hee Cheol , Cho Yong Beom , Huh Jung Wook , Park Yoon Ah , Shin Jung Kyong
Published: August 2021

Purpose: Coronavirus disease 2019 (COVID-19) has affected many parts of daily life and healthcare, including cancer screening and diagnosis. The purpose of this study was to determine whether there was an upshift in the colorectal cancer stage at diagnosis due to delays related to the COVID-19 outbreak.Methods: From January to June of each year from 2017 to 2020, a total of 3,229 patients who were first diagnosed with colorectal cancer were retrospectively reviewed. Those enrolled from 2017 to 2019 were classified as the ‘pre-COVID’ group, and those enrolled in 2020 were classified as the ‘COVID’ group. The primary outcome was the rate of stage IV disease at the time of diagnosis.Results: There was no statistically significant difference in the proportion of stage IV patients between the pre-COVID and COVID groups (P=0.19). The median preoperative carcinoembryonic antigen level in the COVID group was higher than in the pre-COVID group in all stages (all P<0.05). In stage I, II patients who underwent radical surgery, the lymphatic invasion was more presented in COVID patients (P=0.009).Conclusion: We did not find significant stage upshifting in colorectal cancer during the COVID-19 outbreak. However, there were more initially unresectable stage IV colorectal cancer patients with a low conversion rate to resectable status, and more patients had factors related to poor prognosis. These results may become more apparent over time, so it is vital not to neglect cancer screening to not delay the diagnosis during the COVID-19 epidemic.
Analisis Pengaruh Teori Perilaku Terencana pada Niat Beli Produk Tabur Puja
Authors: Gemilang Fhajri Arye , Aulia Allans Prima , Riski Silfia
Published: August 2021

The Purpose of this Research was To Identify the influence of Variabel in Theory of Planned Behaviour (Attitude Toward

Behavior, Subjective Norm, Perceived Behavioral Control) toward Intention to Purchase of Tabur Puja Product (KPRI

Kencana BKKBN Kab. Solok). The Sample of this Research was 115 Respondents of the cooperative member who has

applied the loan application in Tabur Puja Products. Data analisyst used in this Research was Multiple Linear Regression.

Hypothesits in this Research used T and F Test to test The Influnence Indepent Variable toward Dependent Variable. Result

showed that “Attitude Toward Behavior” influenced significantly and positife to the intention to purchase of Tabur Puja

Product. “Subjective Norm” influenced significantly and positife to the intention to purchase of Tabur Puja Product.

“Perceived Behavioral Control” influenced significantly and positife to the intention to purchase of Tabur Puja Product.
Perspective on Crude Palm Oil Production: The Effect of Raw Palm Oil and Biofuel Prices
Authors: Afriany  , Pitoyo Rubianto
Published: August 2021

Efficiency is the important things in production process. Some production factors as labor,

materials, and machinery must be calculate accurately. The purpose of this research is for

analyzing the influence of raw palm oil and Biofuel prices against crude palm oil

production. Sample in this research is time series data that specialized production data, The

technique analysis is using analysis of multiple linier regression. The results from analysis show

correlation between raw palm oil and biofuel prices with crude palm oil production is 57.1 %,

The relationship between raw palm oil against crude palm oil production have significant effect

and biofuel prices against crude palm oil production have no significant effect. Based on the

results of F test there are the significant influence between raw palm oil and biofues prices

against crude palm oil production. finding in this research is PT. Wilmar using 3 type of fuel

for production process, petroleum, biofuel and waste of raw palm oil production which makes

biofuel prices have no effect on crude palm oil production
Pengaruh Penerimaan Pajak Hotel dan Pajak Restoran Terhadap Pendapatan Asli Daerah Provinsi DKI Jakarta
Authors: Rahmiyatun Fitri , Ratiyah  , Hartanti  , Aliudin RM Tedy
Published: August 2021

The purpose of this study was to determine how much influence restaurant tax revenue has on local revenue in DKI Jakarta province.The data that the authors use in this study is data on restaurant tax revenue in the municipality of East Jakarta and data on the original regional income of the province of DKI Jakarta for the period 2011-2018.This research uses the method of observation and literature study with regression analysis, correlation & determination.The results showed that the effect of restaurant tax revenue is quite strong and in line with the r value of 0.970. From the test results the coefficient of determination produces an R Square value of 0.941 or 94.1% and the regression equation Y= 14.706 + 0.636X. These results indicate that restaurant tax has an influence on PAD in DKI Jakarta Province by 94.1% and the remaining 5.9% is influenced by other factors that are not examined.
Pengaruh Kepemimpinan Transformasional, Komunikasi Organisasi Dan Budaya Organisasi Terhadap Kinerja Pegawai Pegawai Dinas Kesehatan Kota (Dkk) Padang
Authors: Azka Bayu Pratama
Published: August 2021

Penelitian ini bertujuan Untuk mengetahui dan menganalisa pengaruh kepemimpinan transformasional, komunikasi organisasi dan budaya organisasi terhadap kinerja Pegawai Pegawai Dinas Kesehatan Kota (DKK) Padang. Populasi dalam penelitian ini adalah seluruh pegawai Dinas Kesehatan Kota (DKK) Padang. Sampel dalam penelitian ini ialah 110 pegawai pada Dinas Kesehatan Kota (DKK) Padang. Analisis data yang dilakukan adalah dengan menggunakan uji validitas, reliabilitas, asumsi klasik, regresi linear berganda, Uji F dan Uji t. Pengujian tersebut dilakukan guna untuk mengetahui pengaruh variabel terhadap varibel terikat. Berdasarkan hasil penelitian ini menemukan bahwa Kepemimpinan Transformasional, Komunikasi Organisasi Dan Budaya Organisasi berpengaruh positif dan signifikan terhadap kinerja Pegawai pegawai Dinas Kesehatan Kota (DKK) Padang.
Pengaruh Ukuran Perusahaan, Kualitas Audit Dan Komite Audit Terhadap Tax Avoidance Dengan Debt Equity Ratio Sebagai Variabel Kontrol
Authors: Pratiwi Hanna
Published: August 2021

Penelitian ini bertujuan untuk mengetahui seberapa besar Pengaruh Ukuran Perusahaan, Kualitas Audit Dan Komite Audit Terhadap Tax Avoidance Dengan Debt Equity Ratio Sebagai Variabel Kontrol pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Dengan mengambil data sekunder yang telah dipublikasikan pada periode 2013-2017. Populasi sebanyak 168 pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia 2013-2017 dan sampel 50 perusahaan pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia 2013-2017. Metode pengumpulan data pada penelitian ini adalah dengan menggunakan bantuan komputer dengan software program EVIEWS versi 9. Metode analisis yang digunakan adalah statistik deskriptif, uji asumsi klasik (Uji Normalitas, Uji Multikolinearitas, Uji Heteroskedastisitas), uji regresi data panel, uji hipotesis secara parsial (Uji Statistik t), uji hipotesis secara simultan (Uji Statistik f), dan uji koefisien determinasi (R2). Hasil penelitian yang diperoleh adalah : Terdapat pengaruh negatif dan tidak signifikan antara ukuran perusahaan terhadap tax avoidance pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia. Terdapat pengaruh yang negatif dan tidak signifikan antara kualitas audit terhadap tax avoidance pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia. Terdapat pengaruh yang negatif dan signifikan antara komite audit terhadap tax avoidance pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia. Terdapat pengaruh yang positif dan signifikan antara ukuran perusahaan, kualitas audit dan komite audit secara bersama-sama terhadap tax avoidance dengan DER pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia. Akhir penelitian penulis menyarankan kepada manajemen perusahaan untuk lebih memperhatikan setiap tindakan dan pengambilan keputusan dalam hal laba dan perpajakan.
Pengaruh Ukuran Dewan Direksi, Struktur Modal Dan Kebijakan Deviden Terhadap Nilai Perusahaan
Authors: Mary Hilda , Pratiwi Nila , Andromeda Dewi
Published: August 2021

The study aimed was to analyze the effect of board size (UDD), capital structure (DER), and dividend policy (DPR) used as independent variables and firm value (PBV) used as the dependent variable. The data used are secondary data in the form of financial reports and annual reports from 2013 to 2017. The samples in this study were 100 companies listed on the Indonesia Stock Exchange. The results of the study indicate that the size of the board of directors (UDD) has a positive and significant effect on the value of the company. Capital structure (DER) which shows that it has a positive and significant effect on firm’s value (PBV). While Dividend Policy has a negative and significant effect on firm’s value (PBV).
Tulu, S. Dede Korkut Oğuznâmesi -Boylar ve Soylamalar- Günümüz Türkçesine Sözlü Çevirisi, Dresden Nüshası ve Günbed-i Kâvus/Türkmensahra Elyazması Esasında, Ankara: Nobel Akademik Yayıncılık, 2020, ss. 392, ISBN: 978-625-406-755-6
Authors: YILDIRIM Mükremin
Published: August 2021

Tulu, S. Dede Korkut Oğuznâmesi -Boylar ve Soylamalar- Günümüz Türkçesine Sözlü Çevirisi, Dresden Nüshası ve Günbed-i Kâvus/Türkmensahra Elyazması Esasında, Ankara: Nobel Akademik Yayıncılık, 2020.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT KECEMASAN PASIEN FRAKTUR PRE OPERASI
Authors: Oktarini Siska , Prima Rezi
Published: August 2021

Operasi merupakan salah satu kondisi yang dapat menimbulkan kecemasan, kecemasan yang terjadi pada pasien fraktur berbeda-beda. Penurunan rasa cemas merupakan hal yang penting, karena kecemasan akan dapat meningkatkan resiko pembedahan. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan tingkat kecemasan pada pasien fraktur pre operasi. Desain penelitian ini adalah deskriptif analitik, dengan pendekatan cross-sectional. Teknik pengambilan sample Accidental Sampling, dengan jumlah sample 31 responden. Uji statistic menggunakan uji Chi-Square dengan tingkat signifikan (α = 0,05). Hasil penelitian didapatkan bahwa lebih dari separoh (61,3%) memiliki tingkat kecemasan berat, lebih dari separoh 61,3% berjenis kelamin laki-laki, lebih dari separoh (64,5%) berpendidikan rendah, sebagian besar (80,6%) berstatus ekonomi rendah, dan lebih dari separoh (67,7%) memiliki dukungan keluarga kurang baik.  Berdasarkan uji statistik hubungan variabel jenis kelamin, didapatkan tidak ada hubungan antara jenis kelamin dengan tingkat kecemasan (p=0,274), adanya hubungan antara pendidikan dengan tingkat kecemasan (p=0,007), adanya hubungan antara status ekonomi dengan tingkat kecemasan (p=0,022), tidak ada hubungan yang bermakna antara dukungan keluarga dengan tingkat kecemasan (p=0,127). Dari hasil penelitian ini diharapkan dapat memberikan masukan pada responden agar dapat mengetahui apa saja faktor-faktor yang dapat mempengaruhi tingkat kecemasan dan responden dapat menjaga pola pikir agar terhindar dari cemas yang berlebihan.
Spatial-temporal distribution of birds in the northern macroslope of the Kyrgyz mountain ridge (Tien Shan)
Authors: Davranov E. , Lyalina M. I.
Published: August 2021

Based on the results of our analysis, a classification of bird species of the Kyrgyz mountain ridge (Northern Tien Shan) was compiled according to their preference for habitats and occurrence throughout the year. The program of factorial classification used for this unites species according to the maximum similarity in their distribution and stay in an unspecified number of clusters. In total, 4 supertypes and 12 types of preferences have been identified along the Kyrgyz ridge. In the supertype of birds that prefer undeveloped areas, 6 types were distinguished, namely, the species choosing: 1 – high mountains, 2 – high and medium mountains, 3 – medium mountains, 4 – medium mountains and foothills, 5 – foothills, and 6 – found at all heights. The supertype of birds preferring built-up areas is represented by one type only: the species preferring foothill sheaths and villages, and the supertype of birds preferring rivers and their banks is represented by four types, namely, the species preferring: high-mountain rivers in the summer and autumn; high-altitude and mid-mountain rivers in the spring and summer; mid-mountain rivers in the autumn; and foothill rivers in the first half of the summer. The supertype uniting species found in all habitats is represented by one type of preference, namely, found throughout the whole year. It is shown that of the 154 recorded bird species, most were found in undeveloped habitats, and 6 and 12 times less were in built-up areas and rivers, including their banks. In undeveloped areas, most bird species prefer high- and mid-mountainous landscapes and half as many prefer foothill landscapes. In residential landscapes, most species tend to the foothills, and among rivers, they prefer high-altitude and mid-mountain areas. At to the seasons, the maximum number of species was recorded in the spring-summer and summer periods.
Spatial distribution of picoseston in the Saratov reservoir in summer
Authors: Krasnova E. S. , Umanskaya M. V.
Published: August 2021

The structure and spatial distribution of picoseston in the Saratov reservoir in July 2011 and August 2014 are described. On average, the total abundance of cells and particles forming picoseston was 1.87±0.73×106 cells (part.)/mL; and the total biomass of picoseston was 43.8±19.4 µg C/L. During the study period, solitary heterotrophic bacteria and phototrophic picocyanobacteria prevailed in the picoseston of the Saratov reservoir, amounting to 77–100% of its total abundance and biomass. The proportion of picodetrital particles was extremely small (on average, 4.1% of the total biomass of picoseston). The high heterogeneity of picoceston distribution (Cv is 130% and 110% for abundance and biomass, respectively) was found in the Saratov reservoir during the study period. On average, the abundance and biomass of heterotrophic bacterioplaknton and picodetritus at stations of the tributary estuaries were slightly higher than in the riverbed. At the same time, the abundance of picocyanobacteria was higher, and the biomass was lower at the estuarine stations compared to the riverbed ones. The total number of bacterioplankton and autotrophic picoplankton in the Saratov reservoir in 2011 and 2014 corresponded to the mesotrophic level of productivity. Picodetrital particles, in contrast to the Upper Volga and Kama reservoirs, make no significant contribution to the planktonic food webs of the Saratov reservoir, at least during the study period.
ON DISTRTBUTION PATTERN OF AMORPHA FRUTICOSA L. IN THE REGION OF KANEVSKAYA HYDROPOWER STATION (UKRAINE) IN CONNECTION WITH HYDROCHORY
Authors: Shevchik T. V. , Dvirna T. S. , Shevchik V. L.
Published: August 2021

Amorpha fruticosa L. is a kenophyte of North American origin, ergaziophyte. Currently, this species naturalized over large areas and became the background on the coast waters of the Dnieper reservoirs of hydropower stations. It is necessary to clarify the reasons for the distribution of A. fruticosa populations in different parts of the Middle Dnieper coast under conditions of artificial regulation of its water yield. It has been proven that the high buoyancy of A. fruticosa fruits provides the possibility of its active dispersal along river beds in a natural way under conditions of fluctuations in the level of surface water yield right in spring floods. The main and determining factor in the active dissemination of the species on the coast of the Kanev and Kremenchug reservoirs is the frequent variability of the maximum water surface level. The narrow altitudinal range of distribution of this species on the coast in the lower parts, and accordingly, wider in the upper parts of the reservoirs is determined by the corresponding indicators of water level differences. The possibility of artificial regulation of the water surface level with knowledge of the characteristics of hydrochory of this invasive species makes it possible to influence its distribution in the territory near the reservoirs.
MASLOZERO LAKE ECOSYSTEM AND THE RESULTS OF THE RELEASE OF THE SMELT OSMERUS EPERLANUS INTO THE LAKE
Authors: Ilmast N. V. , Sterligova O. P. , Kuchko Ya. A. , Sharov A. N. , Savosin E. S. , Savosin D. S.
Published: August 2021

The results of the study of the Maslozero Lake ecosystem (the White Sea basin) are reported. The lake is small, deep and poorly lotic. Its hydrochemical and hydrobiological indices were studied. The quantitative and structural indices of the state of the lake’s zooplankton and macrozoobenthos are presented for the first time. The lake is an oligo-mesotrophic water body type, as indicated by the nutrient content scale. The lake is inhabited by 14 fish species of 11 families. The perch Perca fluviatilis , the whitefish Coregonus lavaretus, the pike Esox lucius, the roach Rutilus rutilus and the introduced smelt Osmerus eperlanus are most abundant. The introduction of the smelt into Maslozero Lake is appraised. The smelt in the lake has naturalized, is successfully reproducing and has become abundant. Its growth rate is identical to that of the smelt from its parental water body - Ladoga Lake. The food ration of predatory fish (pike, burbot, perch and char) is dominated by smelt as the most abundant and accessible food item available all year round. The lake is used by the local population for economic purposes, recreation, amateur fishing and fish culture.
NEW FINDINGS OF STEPPE SPECIES OF CRICKETS OECANTHUS PELLUCENS (SCOPOLI, 1763) AND MODICOGRYLLUS FRONTALIS (FIEBER, 1844) (ORTHOPTERA, ENSIFERA, GRYLLIDAE) IN BELARUS
Authors: Ostrovsky A. М.
Published: August 2021

The data on new for Belarus finds of the steppe species of crickets Oecanthus pellucens (Scopoli, 1763) and Modicogryllus frontalis (Fieber, 1844) is given. The material was collected in August 2019, May and July 2020 in the Bragin district of the Gomel region. Brief information on the current distribution, as well as the characteristics of biology and ecology of each species, is presented.
HOME CLASS: EDUCATIONAL ALTERNATIVE IN TIMES OF PANDEMIC FOR STUDENTS ENROLLED IN BASIC EDUCATION IN THE STATE OF AMAZONAS, BRAZIL
Authors: Ribeiro Melise Maia
Published: August 2021

The objective of this research is to know new decisions about the teaching and learning process in the context of the pandemic in the state of Amazonas, Brazil. The pandemic suspended classroom classes at more than 200 schools, causing the reorganization of pedagogical practices in distance education. The result was the applicability of the Special Regime of Non-Attendance Classes adopted by the Government of Amazonas (Aula em Casa Project). It is concluded that new directions can be taken from formal education in view of this new reality.
Multitask Deep Learning Reconstruction and Localization of Lesions in Limited Angle Diffuse Optical Tomography
Authors: Ben Yedder Hanene , Cardoen Ben , Hamarneh Ghassan
Published: August 2021

Diffuse optical tomography (DOT) leverages near-infrared light propagation through tissue to assess its optical properties and identify abnormalities.

DOT image reconstruction from limited-angle data acquisition is severely ill-posed due to the highly scattered photons in the medium and the relatively small number of collected projections. Reconstructions are thus commonly marred by artifacts and, as a result, it is difficult to obtain accurate reconstruction of target objects, e.g., malignant lesions.

Reconstruction does not always ensure good localization of small lesions. Furthermore, conventional optimization-based reconstruction methods are computationally expensive, rendering them too slow for real-time imaging applications.

Our goal is to develop a fast and accurate image reconstruction method using deep learning, where multitask learning ensures accurate lesion localization in addition to improved reconstruction.

We apply spatial-wise attention and a distance transform based loss function in a novel multitask learning formulation to improve localization and reconstruction compared to single-task optimized methods.

Given the scarcity of real-world sensor-image pairs required for training supervised deep learning models,

we leverage physics-based simulation to generate synthetic datasets and use a transfer learning module to align the sensor domain distribution between in silico and real-world data, while taking advantage of cross-domain learning.

Both quantitative and qualitative results on phantom and real data indicate the superiority of our multitask method in the reconstruction and localization of lesions in tissue compared to state-of-the-art methods.

The results demonstrate that multitask learning provides sharper and more accurate reconstruction.
You can Try without Visiting: A Comprehensive Survey on Virtually Try-on Outfits
Authors: Ghodhbani Hajer , Alimi Adel , Neji Mohamed , Razzak Imran
Published: August 2021

Our work aims to conduct a
comprehensive literature review of deep learning methods applied in the fashion
industry and, especially, the image-based virtual fitting task by citing
research works published in the last years. We have summarized
their challenges, their main frameworks, the popular benchmark datasets, and
the different evaluation metrics. Also,
some promising future research directions are discussed to propose improvements
in this research field.
The influence of extreme weather events on farm economic performance – a case study from Serbia
Authors: Todorović Saša , Ivanović Sanjin , Bogdanov Natalija
Published: August 2021

Western Balkan region, particularly Serbia, is faced with an increased frequency of extreme weather events, as a consequence of global climate change. However, there is still no enough research on how the effects of extreme weather events could be measured on the farm level. More importantly, there is no standard international methodology that is used regularly to address the issue. Therefore, the aim of this research was to evaluate the effects of extreme weather events on business performances of two the most common farm types in Serbia. To achieve this goal, the authors performed a financial loss assessment on a farm level. Panel models and R software environment were used to perform a multiple regression analysis allowing to indicate determinants of financial loss indicator depending on the farm’s production type. The results indicated that performance of both farm types is more influenced by drought than by floods. The regression analysis revealed that for both farm types financial stress is the most important independent variable.
Psychological Responses Among Healthcare Workers Providing Care for Patients with COVID-19: A Web-Based Cross-Sectional Survey in Riyadh, Saudi Arabia
Authors: Abuzied Yacoub , Al-Amer Rasmieh , Somduth Shreemathie , Silva Gerald , Muthuraj Anitha , AlEnizi Saad , AlGhamdi Khalid
Published: August 2021

Introduction

Coronavirus disease (COVID-19) is a pandemic of international concern that has caused significant physical and psychological health challenges to healthcare workers worldwide. This study aimed to assess and evaluate the psychological responses of healthcare workers who provided hands-on care for patients with COVID-19 at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, as it was converted to a dedicated COVID-19 hospital during the pandemic.

Methods

This study used a descriptive cross-sectional design to recruit 500 participants at KFMC between April 10 and May 5, 2020. This study used the 21-item Depression, Anxiety, and Stress Scale (DASS-21) to assess the psychological responses among the study participants.

Results

The findings of this study showed that of 500 respondents, 304 (60.9%) reported having depressive symptoms, 281 (56.3%), 318 (63.3%) having stress and anxiety symptoms. Moreover, 250 participants (50%) who lived with their families reported severe stress and anxiety. However, the results of our study indicated that healthcare workers were committed to providing care to COVID-19 patients.

Conclusions

Depression, anxiety, and stress symptoms were highly prevalent among healthcare workers at KFMC. Therefore, there is an urgent need for psychological interventions to identify healthcare workers with heavy psychological burdens.
UTILIZAÇÃO DA AREIA MARINHA PARA PRODUÇÃO DE CONCRETO: ESTUDO DE VIABILIDADE
Authors: S. Cardoso Wandercleiton , Gonçalves de Oliveira Filho Amandio , Lauret Cosme Renée , Batista dos Santos Benigno , Favalessa Lessa Diógenes
Published: August 2021

A indústria da construção civil tem destacado papel na sociedade brasileira devido a sua importância socioeconômica. Estudos conduzidos no Brasil e no exterior apontam que a areia marinha se apresenta como uma alternativa viável na construção civil. Nesta direção, esta pesquisa analisa uma amostra de agregado miúdo do litoral da Serra/ES, Brasil. Foram realizados ensaios de composição granulométrica, massa específica, teor de argilas em torrões, teor de materiais friáveis, teor de materiais pulverulentos, dimensão máxima característica, avaliação de impurezas orgânicas solúveis, teor de cloretos solúveis, teor de sais solúveis, teor de sulfatos solúveis, teor de materiais carbonosos e pH e resistência a compressão uniaxial. Os ensaios colorimétricos de avaliação de penetração de cloretos no concreto, imerso em água do mar durante 7 dias, não destacaram a presença de cloretos livres em nenhuma das amostras. Ensaios de carbonatação não revelaram processos de carbonatação nos três corpos de prova analisados. Os ensaios de resistência à compressão mostraram que o concreto moldado com areia marinha possui resultados próximos ao moldado com areia de rio.
Reseña del III Congreso Internacional de Investigación Educativa RedCA 2020 La Producción de Conocimiento Interdisciplinario, Interinstitucional e Intercultural
Authors: Carreto Bernal Fernando , Carreto Jr Fernando
Published: August 2021

El propósito de la presente comunicación es reseñar el III Congreso Internacional en Investigación Educativa RedCA 2020, evento organizado del 18 al 20 de noviembre del 2020 en modalidad virtual por los integrantes de la Red de Cuerpos Académicos de Investigación Educativa de la UAEM.  
A partir de un proceso de organización sistemática y con la integración de un sistema automatizado del registro de los participantes, se generó una base de datos, del cual se deriva en primera instancia la caracterización de; ponentes, temáticas y modalidades de participación, mesas de trabajo, así como las instituciones representadas entre otros aspectos.