bluuebunny/crossref_metadata_2025 huggingface dataset:
Cutting parameters influence on surface integrity of dry-turned Ti6Al4V alloy
Authors: Martín-Béjar Sergio , Trujillo Vilches Francisco Javier , Herrera Fernández Manuel , Bermudo Gamboa Carolina , Sevilla Hurtado Lorenzo
Published: September 2023

Surface integrity is a high-interest characteristic of machined parts in the aeronautical industry. Numerous variables are related to the surface integrity and require to be studied as a whole. Generally, the cutting parameters affect these variables’ results, especially in sustainable machining operations. This work analyses the cutting speed and feed influence on different parameters such as the roughness, macrogeometrical deviations and microhardness of Ti6Al4 V turned in dry. All variables have been taken into account simultaneously, given the synergy between the different input and output variables. In general terms, feed seems to be the most influential variable in macrogeometrical and microgeometrical deviations, while cutting speed affects mainly the microhardness parameter. In addition, an optimisation process has been carried out. In the first step, the optimal cutting parameters were obtained for the lowest cutting speed and the lowest feed values due to the roughness is the predominant variable. Therefore, a second optimisation step was performed excluding this variable, optimising the macrogeometrical deviations and the microhardness. In this case, higher cutting speed and feed values seem to be the optimal cutting parameters. Finally, different decision maps were plotted to facilitate the cutting parameter selection according to the property to optimise.
How Does Denial, Minimization, Justifying, and Blaming Operate in Intimate Partner Abuse Committed by Men: A Systematic Review of the Literature
Authors: Smyth Madeline R. , Teicher Sebastian , Wilde David J.
Published: September 2023

Intimate partner abuse (IPA) is widespread, and denial, minimization, justifying, and blaming (DMJB) are common among people who have committed IPA. Views on the function of DMJB in IPA are mixed, often based on the theoretical standpoint of the authors. This systematic review brings together the knowledge of how distorted accounts operate in IPA committed by men. A systematic review of primary research related to DMJB in heterosexual men who have committed to IPA was conducted. In all, 31 papers were found to meet the inclusion criteria (adult, male-to-female abuse, in western culture, peer reviewed and published in English) and were quality appraised. Data were extracted and analyzed using narrative synthesis. The findings indicate the way DMJB operates in this group is complex. It can represent facilitators of abusive behavior, a way to protect the individual’s identity and self-esteem, and a tool men use instrumentally to achieve goals. Themes were present within and between studies highlighting the complex function of DMJB. A model representing the hypothesized intertwined function of DMJB for IPA is proposed. The limitations of the review are discussed and implications and recommendations for policy, practice, and future research are proposed.
Key Lessons From a Systematic Behavior Change Communication Process Used in a Pneumonia Prevention Program in Five African Countries
Authors: González Hernández Libertad , Jiffaro Seje Selam , Mitiku Gosa Abiyot , Goro Helena Goroi , Heuberger Lotte , Giles-Hansen Chelsea
Published: September 2023

Background

A systematic behavior change communication (BCC) process was designed to enable local partners to effectively conduct formative research and develop a comprehensive BCC strategy, as part of a pneumonia prevention and control program implemented from 2017 to 2021 by the Red Cross Red Crescent in Ethiopia, Ivory Coast, Mali, Sudan, and Zambia.

Methods

Qualitative content analysis was used to identify, categorize, and summarize key results, lessons, and recommendations related to the BCC process from country evaluation data.

Results

Key elements to success of a locally implemented BCC process include: (1) through simple formative research, understanding household decision-making dynamics for timely health seeking and coexistence of modern and traditional medicine; (2) explicitly analyze motivators for uptake of protective behaviors, with strong and deliberate community participation to validate and tailor BCC messages and channels; (3) ensuring that the challenges to access basic services, such as water and sanitation facilities, are adequately addressed as critical enabling factors for behavior change. Other implications include a need for innovative solutions to physical and economic barriers in areas where large distances, lack of transportation, or cost hinder caregivers seeking care for sick children.

Conclusions

Community health programs that apply a BCC process through local partners can be effective in achieving behavioral outcomes. Participatory planning and involvement of the community in iterative rounds of validation improved the relevance, appropriateness, and impact. Further research is needed to determine the effectiveness of different communication methods and sustained impact on health outcomes.
Infrapopliteal 3-Vessel Occlusive Disease Is the Only Predictor of Wound Recurrence After Complete Wound Healing via Endovascular Therapy in Patients With Chronic Limb-threatening Ischemia
Authors: Yanagiuchi Takashi , Kato Taku , Hirano Keita , Hanabusa Katsuyuki , Ota Yutaro , Yamazaki Shinya , Fushimura Yohei , Ushimaru Shunpei , Yokoi Hirokazu , Zen Kan , Matoba Satoaki
Published: September 2023

Purpose:

To determine the predictors of wound recurrence after complete wound healing in patients with chronic limb-threatening ischemia (CLTI) who underwent endovascular therapy (EVT) for infrapopliteal (IP) lesions with consideration of IP arterial anatomic severity, including classification by the Global Limb Anatomic Staging System (GLASS).

Materials and Methods:

This retrospective single-center study assessed patients with de novo CLTI limbs with tissue loss treated via EVT for IP lesions from September 2016 to May 2021. Among these patients, 149 consecutive limbs from 133 patients who achieved complete wound healing were enrolled. The Kaplan-Meier method was used to estimate the wound recurrence rate after complete wound healing. The Cox proportional hazard model was used to assess the association between baseline characteristics and wound recurrence.

Results:

The cumulative wound recurrence rate 1 year after complete wound healing was 30%. The mean time for wound recurrence was 7±5 months. Only IP arterial anatomic characteristics remained as a predictor of wound recurrence, whereas wound status and management, including the Wound, Ischemia, and foot Infection (WIfI) clinical stage and minor amputation, were not associated with wound recurrence. Multivariate analysis revealed independent associations between wound recurrence and IP 3-vessel occlusive disease (hazard ratio, 2.97; 95% confidence interval, 1.39–6.35), but not poor below-the-ankle runoff, IP Peripheral Arterial Calcium Scoring System (PACSS) grade, and the GLASS IP grade.

Conclusion:

The only independent predictor of wound recurrence after complete wound healing via EVT in patients with CLTI was IP 3-vessel occlusive disease.

Clinical Impact

In patients with chronic limb-threatening ischemia (CLTI), wound recurrence after complete wound healing remains a challenge, and studies focused exclusively on wound recurrence are still limited. The present study aimed to determine the risk factors for wound recurrence after complete wound healing in patients with CLTI who underwent endovascular therapy (EVT) for infrapopliteal (IP) lesions, with consideration of IP arterial anatomic severity for the first time. The results showed that IP 3-vessel occlusive disease was the only predictor of wound recurrence, whereas wound status/management and other arterial anatomic characteristics including WIfI clinical stages and GLASS grades were not predictors.
Association of Monocyte to Lymphocyte, Neutrophil to Lymphocyte, and Platelet to Lymphocyte Ratios With Non-Healing Lower Extremity Ulcers in Patients With Type 2 Diabetes
Authors: Gao Hai , Yi Yangyan
Published: September 2023

Objective

Diabetic ulcers are a prevalent complication of diabetes mellitus and represent one of the most complex and severe complications that can occur in diabetic patients. Most existing studies have separately examined the neutrophil-to-lymphocyte ratio (NLR) prognostic value or the platelet-to-lymphocyte ratio (PLR). However, to our knowledge, no study has evaluated the relationship between the monocyte-to-lymphocyte ratio (MLR) and non-healing lower extremity ulcers (NHLU) in patients. This study explored the association between 3 hematological parameters (MLR, NLR, and PLR) and the risk of non-healing ulceration in patients with type 2 diabetes (T2D).

Methods

A cross-sectional study was performed using data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2004. The primary outcome variable was NHLU status, determined by patients’ self-reported responses to the question, “Have you had an ulcer or sore on your leg or foot that took more than four weeks to heal?” Logistic regression examined the relationships between MLR, NLR, PLR, and NHLU. Stratified analyses were also conducted based on age, gender, hemoglobin (HGB) level, and body mass index (BMI).

Results

In the multivariate regression models, after adjusting for age, sex, race/ethnicity, marital status, poverty income ratio (PIR), BMI, HGB, family history of diabetes, and low-density lipoprotein (model 3), the odds ratios (ORs) of MLR and NLR were 1.21 (1.09-1.33) and 1.02 (1.01-1.03), respectively. However, the association was no longer statistically significant for the NLR (OR = 1.0002, 95% CI: 0.99-1.0005, P = .137). In the subgroup analysis, the effect sizes of MLR and NLR on the presence of NHLU were stable in all subgroups (all P > .05).

Conclusions

After adjusting for confounding variables, MLR and NLR were significantly increased in T2D participants with NHLU. They may play a significant role in monitoring T2D patients during follow-up visits.
Neonatal Hip Loading in Developmental Dysplasia: Finite Element Simulation of Proximal Femur Growth and Treatment
Authors: Sadeghian S. Mahsa , Arthurs Owen J. , Li Xinshan , Lewis Cara L. , Shefelbine Sandra J.
Published: September 2023

Background:

Abnormal prenatal hip joint loading can lead to compromised hip joint function. Early intervention is crucial for favorable outcomes.

Purpose:

This study investigates the impact of treatment timing (initiation and duration) on cartilage growth and ossification in the proximal femur of infants with developmental dysplasia of the hip, a condition affecting newborns.

Methods:

We used a mechanobiological model to simulate proximal femur growth during treatment durations of 3 months, 6 months, and a late-start treatment.

Results:

The findings indicate that the timing of treatment initiation is crucial, while a longer treatment duration does not contribute to improved morphological development of the hip joint.

Conclusions:

Mechanobiological models of growth can be used to develop treatments and therapies that correct loading conditions. Growing bone is particularly sensitive to loading conditions, and altered loading during growth can affect bone shape and functionality.
Chronic illness and psychopathology in emerging adults: Moderation by parent–child relationship quality
Authors: Kukay Abigail , McKinney Cliff
Published: September 2023

Objective

The current study aimed to better understand how parent–child relationships might moderate the effects of the presence and severity (as measured by physical quality of life) of a chronic illness on psychological problems in emerging adulthood.

Methods

The participants included 538 emerging adults (53.5% women) with a mean age of 19.04. The participants completed an online study including chronic illness questions, the World Health Organization Quality of Life—Brief, the Parental Environment Questionnaire, and the Adult Self-Report scale.

Results

Endorsing a health condition significantly associated with psychological problems in emerging adult men. The three-way interaction between endorsing a health condition, physical quality of life, and maternal parent–child relationship quality significantly predicted psychological problems in emerging adult men and women. Specifically, higher maternal relationship quality was associated with a weaker relation between psychological problems and having a health condition with a low physical quality of life.

Discussion

The emerging adults who reported the most psychological problems also reported having a health condition, low physical quality of life, and low maternal relationship quality, highlighting that the combination of these variables predicted the highest rate of psychological problems. A low maternal relationship quality contributes to poor psychological adjustment while a high maternal relationship quality contributes to good psychological adjustment.
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus
Authors: Hornung Rebecca S , Kinchington Paul R , Umorin Mikhail , Kramer Phillip R
Published: September 2023

Infection with varicella zoster virus (VZV) results in chicken pox and reactivation of VZV results in herpes zoster (HZ) or what is often referred to as shingles. Patients with HZ experience decreased motivation and increased emotional distress consistent with functions of the ventral tegmental area (VTA) of the brain. In addition, activity within the ventral tegmental area is altered in patients with HZ. HZ primarily affects individuals that are older and the VTA changes with age. To begin to determine if the VTA has a role in HZ symptoms, a screen of 10,000 genes within the VTA in young and old male rats was completed after injecting the whisker pad with VZV. The two genes that had maximal change were membrane progesterone receptors PAQR8 (mPRβ) and PAQR9 (mPRε). Neurons and non-neuronal cells expressed both PAQR8 and PAQR9. PAQR8 and PAQR9 protein expression was significantly reduced after VZV injection of young males. In old rats PAQR9 protein expression was significantly increased after VZV injection and PAQR9 protein expression was reduced in aged male rats versus young rats. Consistent with previous results, pain significantly increased after VZV injection of the whisker pad and aged animals showed significantly more pain than young animals. Our data suggests that PAQR8 and PAQR9 expression is altered by VZV injection and that these changes are affected by age.
A multi-dimensional learning strategy to foster research integrity
Authors: Pizzolato Daniel , Dierickx Kris
Published: September 2023

Responsible research practices are critical to maintaining integrity in research and the provision of institutional trainings is an important means of promoting research integrity. However, studies show contrasting results on the efficacy of institutional training and that these approaches may not be fully effective in promoting research integrity among individuals and improving the overall climate in research integrity. Therefore, a more comprehensive multi-dimensional learning strategy seems to be needed. This includes continuous and tailored training at different institutional levels, the incorporation of training sessions focusing on the development of the moral character of researchers, and the use of different mentoring practices. With this comprehensive approach, research institutions can foster a culture of integrity in research, improve the overall research integrity climate and promote responsible research practices by individuals.
Peri-articular fractures of the hand
Authors: Li Jefferson , Ghulam-Jelani Zohal , Hoekzema Nathan
Published: September 2023

Peri-articular fractures of the hand are common injuries. Long-term consequences can be relatively innocuous or severely disabling. Due to the specific anatomy of the hand, avulsion fractures are likely more common here than anywhere else in the body and often occur at or near joints. The management of peri-articular fractures of the hand requires consideration of both the articular reduction and the status of ligament and tendon attachments. In general, these fractures can be treated non-operatively. Operative treatment can be percutaneous or open and should be individualized.
Fractures of the phalanges
Authors: Heifner John J. , Rubio Francisco
Published: September 2023

Fractures of the phalanges encompass a wide range of injury patterns with variable articular and soft tissue involvement. The goals of treatment whether conservative or surgical are the restoration of function while limiting the risk of complications. An armamentarium of fixation options allows the surgeon to appropriately treat these fractures with the intention of initiating early postoperative mobilization. Previous publications report variable rates of complications following internal fixation of phalangeal fractures which represents an unsolved problem. It is incumbent on the surgeon to utilize meticulous surgical technique, achieve anatomic reduction with stable fixation and initiate early postoperative mobilization where indicated. In the following text, we review the management of most types of phalangeal fractures, except fracture-dislocations of the proximal interphalangeal joint. These injuries comprise a wide spectrum of presentation; thus, an understanding of anatomical and mechanical principles is integral to achieving a successful outcome.
A documentary analysis of Victorian Government health information assets’ websites to identify availability of documentation for data sharing and reuse in Australia
Authors: Riley Merilyn , Kilkenny Monique F. , Robinson Kerin , Leggat Sandra G.
Published: September 2023

Background:

Health data sharing is important for monitoring diseases, policy and practice, and planning health services. If health data are used for secondary purposes, information needs to be provided to assist in reuse.

Objectives:

To review government health information asset websites to ascertain the extent of readily available, explanatory documentation for researcher sharing and reuse of these data.

Method:

Documentary analysis was undertaken on selected Victorian Government health information assets’ websites in Australia. Data were obtained on nine information-categories: data custodian; data context; data dictionary; quality controls; data quality; limitations; access process; privacy/confidentiality/security and research requests/outputs. Information-categories were compared by dataset type (administrative or population-health) and by curating organisation (government or other agency). Descriptive statistics were used.

Results:

The majority of the 25 websites examined provided information on data custodian (96%) and data context (92%). Two-thirds reported access process (68%) and privacy/confidentiality/security information (64%). Compared with population-health websites, administrative dataset websites were more likely to provide access to a data dictionary (67% vs 50%) and information on quality controls (56% vs 44%), but less likely to provide information on the access process (56% vs 75%) and on research requests/outputs (0% vs 56%, p = 0.024). Compared with government-curated websites, other agency websites were more likely to provide information on research requests/outputs (80% vs 7%, p < 0.001).

Conclusion:

There is inconsistent explanatory documentation available for researchers for reuse of Victorian Government health datasets. Importantly, there is insufficient information on data quality or dataset limitations. Research-curated dataset websites are significantly more transparent in displaying research requests or outputs.
Tendon tissue engineering: An overview of biologics to promote tendon healing and repair
Authors: Citro Vera , Clerici Marta , Boccaccini Aldo R. , Della Porta Giovanna , Maffulli Nicola , Forsyth Nicholas R.
Published: September 2023

Tendons are dense connective tissues with a hierarchical polarized structure that respond to and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion and maintaining posture. Tendon injuries, also known as tendinopathies, are becoming more common as populations age and participation in sports/leisure activities increases. The tendon has a poor ability to self-heal and regenerate given its intrinsic, constrained vascular supply and exposure to frequent, severe loading. There is a lack of understanding of the underlying pathophysiology, and it is not surprising that disorder-targeted medicines have only been partially effective at best. Recent tissue engineering approaches have emerged as a potential tool to drive tendon regeneration and healing. In this review, we investigated the physiochemical factors involved in tendon ontogeny and discussed their potential application in vitro to reproduce functional and self-renewing tendon tissue. We sought to understand whether stem cells are capable of forming tendons, how they can be directed towards the tenogenic lineage, and how their growth is regulated and monitored during the entire differentiation path. Finally, we showed recent developments in tendon tissue engineering, specifically the use of mesenchymal stem cells (MSCs), which can differentiate into tendon cells, as well as the potential role of extracellular vesicles (EVs) in tendon regeneration and their potential for use in accelerating the healing response after injury.
Implementing gradual, hyperbolic tapering of long-acting injectable antipsychotics by prolonging the inter-dose interval: an in silico modelling study
Authors: O’Neill James R. , Taylor David M. , Horowitz Mark A.
Published: September 2023

Gradual, hyperbolic tapering has been proposed as a method to reduce the risk of withdrawal effects and potential relapse of an underlying condition by minimising disruption of existing equilibria. We applied hyperbolic tapering principles in silico to long-acting aripiprazole to generate regimens for withdrawal in clinical practice. We derived thresholds for taper rates using existing studies and consensus. Using pharmacokinetic data for aripiprazole long-acting injectable antipsychotic (ALAI), we conducted in silico modelling to examine the impact of abrupt cessation of long-acting injectable antipsychotic (LAI) medication and the effect of prolonging inter-dose interval on plasma aripiprazole levels and consequent D2 occupancy. We also modelled transitions from LAI medication to oral medication. Regimens were designed to afford a rate of reduction between 5 and 12.5 percentage points of D2 occupancy per month. Abrupt discontinuation of ALAI was shown to lead to a maximal D2 occupancy reduction of 16.8 percentage points per month; prolongation of the inter-dose interval of ALAI produced a slower reduction. Specifically, hyperbolic tapering was afforded by prolongation of a 400 mg ALAI inter-dose interval from 4 to 7 weeks, before reducing the dose to 300 mg ALAI. This could then be administered at up to 4-week (for 6% maximal D2 occupancy change), 6-week (9% change) or 7-week (11% change) intervals. Switching to oral medication – 5, 2.5 and 1.25 mg for the three regimens, respectively – is required for ALAI to complete full cessation to prevent too rapid a reduction in D2 occupancy. Oral medication should probably be maintained at a consistent dose for 3–6 months before further reductions to account for residual LAI being concurrently eliminated. Hyperbolic dose tapering is possible with ALAI through prolongation of the inter-dose interval and may reduce the risk of relapse compared to abrupt discontinuation of LAI medication.
Under the Shadow of Culture and Politics: Understanding LGBTQ Social Media Activists’ Perceptions, Concerns, and Strategies
Authors: Oz Mustafa , Yanik Akan , Batu Mikail
Published: September 2023

This study aimed to explore the perceptions, concerns, and strategies of LGBTQ social media activists in Turkey. Through semi-structured interviews with 20 LGBTQ social media activists, we investigated how they navigate cultural and political challenges and utilize social media for activism purposes. Our findings revealed that LGBTQ activists in Turkey strive to balance the risks and benefits of being online activists. They aim to avoid punishment from society and the government while simultaneously asserting their existence and amplifying their voices through social media. In addition, the study highlights the concerns of activists regarding both state and lateral surveillance.
Trust and Safety on Social Media: Understanding the Impact of Anti-Social Behavior and Misinformation on Content Moderation and Platform Governance
Authors: Gruzd Anatoliy , Soares Felipe Bonow , Mai Philip
Published: September 2023

The Special Issue on Trust and Safety on Social Media delves into two pressing and interlinked concerns: the growing prevalence of anti-social behavior and the widespread presence of misinformation within and across various social media platforms. The collection of articles featured in the issue collectively examines factors that contribute to these concerns and proposes potential strategies to mitigate their negative impact on social media users and society. The articles included in the issue are extended versions of research first presented at the 2022 International Conference on Social Media & Society (#SMSociety), organized by the Social Media Lab at Toronto Metropolitan University.
Facebook’s News Feed Algorithm and the 2020 US Election
Authors: Bandy Jack , Diakopoulos Nicholas
Published: September 2023

Facebook plays a substantial role in shaping exposure to news and information, a role that is particularly significant during democratic elections. This article aims to characterize Facebook’s contribution to news exposure during the 2020 US election. Using internet browsing data from 1.3 million desktop panelists in the United States, we analyze audience flows from Facebook to news and information publishers ( N = 3,247 websites) labeled according to quality (high or low) and geography (non-local or local). We find that Facebook ranked as the fourth largest external referral source to publishers. Our analysis further shows that, among the panel of 1.3 million US adults visiting these publishers via desktop computers, Facebook disproportionately amplified low-quality publishers and extended their audience reach during the study period. We also find evidence that Facebook’s intervention to improve “news ecosystem quality” by tweaking their News Feed algorithm was associated with fewer daily visits to low-quality publishers, but seemed to have a similar effect on other publishers and, according to Facebook-provided data, had little effect on month-over-month traffic. We discuss limitations, open questions about platform impact, and directions for future work.
Impact of Financial Agglomeration on Regional Economic Growth in China: A Spatial Correlation Perspective
Authors: Peng Huimin , Qiu Yi
Published: September 2023

In the contemporary world, finance is crucial to economy and financial agglomeration has a lasting effect on the economic growth. The areas of financial agglomeration will influence the economy of the local parts throughout agglomeration effect, and have an impact on its spatially related parts. Based on Chinese inter-provincial panel data from 2007 to 2018, this study constructs an indicator system of financial agglomeration and measures provincial agglomeration levels to examine its impact on regional economic growth. The results show that, first, the level of financial agglomeration has a trend of steady change and presents a ladder-decreasing agglomeration pattern. Second, financial agglomeration could effectively promote the economic growth of local and spatially related regions. The development of the financial industry depended more on geographical distance, and the diffusion effect of financial agglomeration in the eastern, central, and western regions are in different stages. Finally, by summarizing the research conclusions, this study put forward some suggestions for China’s regional economic growth.
The Impact of Employee Recreation on Their Respective Productivity
Authors: Mercanoğlu Anıl Onur , Şimşek Kerem Yıldırım
Published: September 2023

Employee recreation is among the tools, which can be appropriately used to increase employee productivity. In developing countries, both its insufficient use in workplaces, and a lack of academic studies and resources have led to inadequate knowledge and awareness about employee recreation. In this regard, the aim of this study was to test the applicability of employee recreation and its impact on employee productivity through a comprehensive recreation program. The research was carried out according to the Solomon Four Group Design. An employee recreation program covering 6 days a week was used as the intervention. The program was implemented for 6 weeks. The research group consisted of 101 employees of a medium-sized workplace in an Organized Industrial Zone. Significant differences were found in both within-group and between-group comparisons. As a result of the study, it was found that the employee recreation program had a large and positive effect on employee productivity.
Fictionalizing the Language of Power: A Comparative Study of Pakistani and Latin American Novels
Authors: Ali Sadia , Ali Muhammad , Ghani Muhammad Usman
Published: September 2023

Latin American dictator fiction has a long tradition and is widely acclaimed in critical studies, while Pakistani dictator fiction began to emerge in recent years. The study is analytical and comparative research based on the contents of two culturally, historically, and geographically diverse novels—Mario Vargas Llosa’s The Feast of the Goat and Mohammad Hanif’s A Case of Exploding Mangoes so as to locate their common and contrasting aspects. It is a qualitative study and through content analysis, it finds convergences and divergences between a Latin American and a Pakistani dictator novel. A special emphasis of the study is on power, dictator portrayal, torture, resistance, retelling/rewriting history, and representation. The study concludes that where Llosa presents the detailed description of events related to the atrocious regime of Trujillo, Hanif presents a partial and not the whole view of Zia’s dictatorship. Llosa misses no opportunity to create the sentiments of detestation and wrath against the despotic rule and his language throbs with bitterness and becomes satiric while unveiling the dark aspects of the Trujillo regime. However, Hanif, instead of giving a detailed and direct portrayal of certain dark aspects and brutalities, gives just oblique references to them and even the events which he brings to the forefront are presented in a very light and humorous vein which fail to arouse the emotions of abhorrence and denouncement against the despotic rule.
Influence of Playability on Perceived Game Software Quality: A Comparison Between Chinese and South Korean Gamers
Authors: Jiang Jialei , Wong Philip Pong Weng , Wang Lei
Published: September 2023

The usability of ISO/IEC 25000 series SQuaRE and other existing software quality models seems unsuitable for unique software products such as game software. This study revealed that playability has a higher predictive capacity than usability for evaluating game software quality using a survey methodology involving 344 Chinese respondents and 142 South Korean respondents. Specifically, dimensions of playability in terms of enjoyable, exciting, fun, interesting, relaxing, novel, creative, convenient, curious, fantastic, stimulating, splendid, effective and attractive positively influenced both Chinese and South Korean game software users’ satisfaction. In addition, results show that there is a significant difference between Chinese and South Koreans in playability dimensions such as exciting, relaxing, novel, creative, convenient, curious, stimulating, splendid and attractive. This study extends the existing knowledge on how playability influenced game software users’ satisfaction and software quality, and limitations were also highlighted.
‘Deteriorating Our Relationship for no Good Reason’: Collegiate Beat Writers’ Perceptions of Their PR Counterparts
Authors: Stamm Jason , Boatwright Brandon
Published: September 2023

This study examines the contemporary nature of the relationship between sport journalists and media relations personnel, particularly within the context of collegiate athletics. Despite years of sharing a “symbiotic relationship” wherein both sides benefited from the success of the other, sports media professionals have cited a strained rapport, as sports information directors (SIDs) and media relations personnel have taken internal positions aimed at producing content comparable to what sports media have traditionally developed. Through in-depth interviews with 16 beat writers, the current project identified three salient themes related to beat writers’ perceived relationships with SIDs and media relations professionals representing athletic programs they cover: (1) frustration over the control of information, (2) misperceptions about the media’s value to the organization, and (3) growing uncertainty about the future of the relationship between beat writers and media relations professionals. These findings contribute theory and practice within the context of the Strategic Sport Communication Model (SSCM).
An 11-Year-Long Analysis of the Risks Associated With Age in Patients Undergoing Anterior Cervical Discectomy and Fusion in a Large, Urban Academic Hospital
Authors: Tang Justin , Gal Jonathan S. , Geng Eric , Duey Akiro , Ferriter Pierce , Sicard Ryan , Zaidat Bashar , Girdler Steven , Rhee Hannah , Zapolsky Ivan , Al-attar Paul , Markowitz Jonathan , Kim Jun , Cho Samuel
Published: September 2023

Study Design

A retrospective database study of patients at an urban academic medical center undergoing an Anterior Cervical Discectomy and Fusion (ACDF) surgery between 2008 and 2019.

Objective

ACDF is one of the most common spinal procedures. Old age has been found to be a common risk factor for postoperative complications across a plethora of spine procedures. Little is known about how this risk changes among elderly cohorts such as the difference between elderly (60+) and octogenarian (80+) patients. This study seeks to analyze the disparate rates of complications following elective ACDF between patients aged 60-69 or 70-79 and 80+ at an urban academic medical center.

Methods

We identified patients who had undergone ACDF procedures using CPT codes 22,551, 22,552, and 22,554. Emergent procedures were excluded, and patients were subdivided on the basis of age. Then each cohort was propensity matched for univariate and univariate logistic regression analysis.

Results

The propensity matching resulted in 25 pairs in both the 70-79 and 80+ y.o. cohort comparison and 60-69 and 80+ y.o. cohort comparison. None of the cohorts differed significantly in demographic variables. Differences between elderly cohorts were less pronounced: the 80+ y.o. cohort experienced only significantly higher total direct cost ( P = .03) compared to the 70-79 y.o. cohort and significantly longer operative time ( P = .04) compared to the 60-69 y.o. cohort.

Conclusions

Octogenarian patients do not face much riskier outcomes following elective ACDF procedures than do younger elderly patients. Age alone should not be used to screen patients for ACDF.
A Research on the Current Status of Inclusive Education for Children With Autism in Beijing: Perspectives From Parents of Children With Autism
Authors: Mao Yingmei , Wang Qian
Published: September 2023

To gain a comprehensive understanding of the current status of inclusive education for children with autism in Beijing from the perspectives of parents, a questionnaire-based survey was administered to 202 parents residing in Beijing, whose children have autism. Their experiences with inclusive education, sentiments towards acceptance and support, and preparedness for educational transitions were explored. The results revealed that inclusive education served as the primary educational placement for the majority of children with autism. However, parents perceived a low frequency and efficacy of support extended by mainstream school teachers. Limited acceptance and insufficient professional support continued to pose significant challenges for children with autism in mainstream educational settings. Additionally, there appeared to be a deficiency in the provision of guidance for parents of children with autism concerning educational transitions. It is therefore recommended that efforts be made to enhance the operational mechanism of inclusive education in Beijing and to offer guidance to parents and their children with autism during the process of educational transition.
Can Mindfulness be an Alternative for Servant Leadership? A Well-being Perspective
Authors: Goyal Richa , Sheoran Neha , Sharma Himani
Published: September 2023

Servant leaders go beyond their self-centeredness and genuinely work toward strengthening the well-being (WB) of their followers. However, organizations cannot solely rely on servant leaders to stimulate the WB of their workforce as numerous factors affect servant leadership (SL), which may hinder its successful implementation in the workplace. Therefore, it is essential to determine to what extent an individual trait such as mindfulness can compensate for this leadership. Being focused, optimistic, and present in the moment fosters the WB of a person, which may reduce their reliance on external leadership. Thus, by relying on the “substitutes for leadership theory,” this study examines the moderating role of mindfulness in the SL and WB relationship. The data were collected from the 265 Indian service sector employees and were analyzed using the SPSS-20 and AMOS-21 software. The study’s results revealed that SL and mindfulness were significantly related to employee WB. Moreover, employees’ mindfulness moderates the SL and WB relationship. Also, mindfulness partly substitutes for a low level of SL in the workplace. Hence, by organizing meditation and yoga sessions in the organizations, employees’ mindfulness can be enhanced which reduce the reliance on the leadership style of the managers.
“It’s Not Just Bacteria”: A Cavitary Lung Lesion in a Patient Living in the Coachella Valley
Authors: Kaur Harbir , Thukral Jatin , Lim Anthony , Oberndorf Julia , Sou Andrew , Mdluli Xolani
Published: September 2023

Cavitary pulmonary coccidioidomycosis is rare diagnosis with an incidence of 13% to 15% of pulmonary coccidioidomycosis cases. High clinical suspicion is necessary in the setting of geographical location endemicity. We present a 49-year-old male who has lived in the Coachella Valley of California for several years, with a medical history of uncontrolled type 2 diabetes who noted 1 week of right-sided chest pain with shortness of breath, fever, chills, night sweats, and weight loss. A chest X-ray revealed a 4- to 5-cm mass in the right lung. Initial workup revealed negative sputum cultures (aerobic/anaerobic, acid-fast bacilli). However, dedicated fungal cultures (samples from sputum, lymph nodes, lung right lower lobe bronchial swabs), bronchial washings, and surgical tissue biopsy of the right lower lobe revealed mold. The patient underwent right thoracotomy with right lower lobectomy and right mediastinal lymph node dissection for both diagnostic (lung specimen) and therapeutic (removing necrotic lung tissue, source control) purposes. Finally, serum Coccidioides antigens were positive and antibody titers were positive at 1:8; surgical biopsy of the right lower lobe grew mold that came back positive for Coccidioides posadasii. Targeted pharmacotherapy was commenced using intravenous fluconazole and then oral fluconazole for 3 months was prescribed upon discharge. The patient had gradual improvement of his shortness of breath and was instructed to follow-up at an infectious disease clinic.
Significant improvement of systemic lupus erythematosus manifestation in children after autologous dendritic cell transfer: a case report and review of literature
Authors: Jonny  , Putranto Terawan Agus , Purnama Yenny , Djatmiko Roedi , Yana Martina Lily , Sitepu Enda Cindylosa , Irfon Raoulian
Published: September 2023

Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle weakness. The supporting examinations showed abnormal blood cell counts, positive antinuclear antibody profile, serositis, and neuropathy. Immunosuppressants failed to improve the condition. DC-based vaccine derived from autologous peripheral blood which was introduced with SARS-CoV-2 protein was given to this patient. There was a significant improvement in clinical and laboratory findings. Thus, DC immunotherapy appears to be a potential novel therapy for SLE that needs to be studied.
The Role of Open Business Models in Times of OTT Video Innovation: Evidence from Taiwanese Platforms
Authors: Huang J. Sonia , Ho Foo Nin
Published: September 2023

Watching over-the-top (OTT) video has become the mainstream of daily life worldwide. Except for a few cultural exporters, most countries have experienced a threat of global OTT giants sweeping local audiences. How do local OTT platforms protect local cultures and retain local audiences? From the perspective of media industry studies, this study uses data from four Taiwanese OTT platforms to explore this question and found that Taiwanese OTT platforms are starting to open their business models to external ideas or partners, but the degree of openness has not yet reached the integrated nor the adaptive types. Moreover, we identify six common practices of open business models: (1) cooperation with suppliers, (2) outbound licensing, (3) strategic alliances, (4) buyer–supplier integration, (5) co-opetition, and (6) joint ventures.
Geographic location of students and course choice, completion, and achievement in higher education: A scoping review
Authors: Brownie Sharon , Yan Ann-Rong , Broman Patrick , Comer Leith , Blanchard Denise
Published: September 2023

Higher education provision is a critical enabler of local, regional, and national social and economic development. Benefits of participation are well understood, but less is known about the relationship between the geographic location of students (relative to higher education institutions), their study choices, and subsequent outcomes. This scoping review explored existing evidence about the impact of geographical location (place) on course choices, completion rates, and achievement. Findings suggest that greater distance of students from institutions negatively impacts achievement and program/course completions. Distance to study institutions may also influence study choices, including level and field of study. Higher education providers must consider how best to spread resources regionally and better enable access for those from regional, remote, and/or rural backgrounds. Policymakers should consider location as a key factor in improving access and addressing inequalities in higher education.
How I treat secondary CNS involvement by aggressive lymphomas
Authors: Alderuccio Juan Pablo , Nayak Lakshmi , Cwynarski Kate
Published: September 2023

Secondary central nervous system (CNS) lymphoma (SCNSL) is a rare but clinically challenging scenario with historically disappointing outcomes. SCNSL refers to lymphoma that has spread into the CNS concurrently with systemic disease or CNS relapse during or after frontline immunochemotherapy, presenting with or without systemic lymphoma. Diffuse large B-cell lymphoma (DLBCL) denotes the most common entity, but an increased incidence is observed in other histologies, such as Burkitt lymphoma and mantle-cell lymphoma. The incidence, timing in disease course, location, evidence supporting the use of CNS prophylaxis, and treatment pathways vary according to histology. No randomized data exist to delineate the best treatment approaches with current recommendations based on retrospective and single-arm studies. However, a regimen comprising immunochemotherapy, incorporating agents that cross the blood-brain barrier, followed by thiotepa-containing conditioning and autologous stem-cell transplant outlined in the international MARIETTA study demonstrated improvement in outcomes, representing a major accomplishment in the care of patients with DLBCL with SCNSL. Anti-CD19 chimeric antigen receptor T cell denotes a paradigm shift in the treatment of patients with systemic aggressive lymphomas, with emerging data also demonstrating efficacy without higher neurotoxicity in those with SCNSL. In this manuscript we discuss 5 clinical scenarios and review the evidence supporting our recommendations.
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins
Authors: Hiratsuka Takuya , Ito Shinji , Sakai Rika , Yokose Tomoyuki , Endo Tatsuya , Daigo Yataro , Miyagi Yohei , Tsuruyama Tatsuaki
Published: September 2023

Background

The molecular pathology of diffuse large B cell lymphoma (DLBCL) has been extensively studied. Among DLBCL subtypes, the prognosis of CD5-positive DLBCL is worse than that of CD5-negative DLBCL, considering the central nervous system relapse and poor response to R-CHOP therapy. However, the molecular mechanisms underlying the tumorigenesis and progression of CD5-positive DLBCL remain unknown.

Methods

To identify molecular markers that can be targeted for treating DLBCL, a proteomic study was performed using liquid chromatography-mass spectrometry with chemically pretreated formalin-fixed paraffin-embedded specimens from CD5-positive (n = 5) and CD5-negative DLBCL patients (n = 6).

Results

Twenty-one proteins showed significant downregulation in CD5-positive DLBCL compared to CD5-negative DLBCL. Principal component analysis of protein expression profiling in CD5-positive and CD5-negative DLBCL revealed that DNAJB1, DDX3X, and BTK, which is one of the B cell phenotypic proteins, were the most significantly downregulated proteins and served as biomarkers that distinguished both groups. Additionally, a set of immunoglobulins, including IgG4, exhibited significant downregulation. Immunohistochemistry analysis for BTK demonstrated reduced staining in CD5-positive DLBCL compared to CD5-negative DLBCL.

Conclusions

In conclusion, DNAJB1 and DDX3X, BTK, and a set of immunoglobulins are promising biomarkers. Probably, the suppression of BCR signaling is the unique phenotype of CD5-positive DLBCL. This formalin-fixed paraffin-embedded (FFPE)-based profiling may help to develop novel therapeutic molecularly targeted drugs for treating DLBCL.