bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological Activity of Canned Pork Meat Fortified Black Currant Leaf Extract: In Vitro, In Silico, and Molecular Docking Study
Authors: Wójciak Karolina M. , Kęska Paulina
Published: December 2023

The aim of this study was to assess the antioxidant and inhibiting (ACE-I, DPP IV, and alpha-glucosidase) potential of canned meat featuring reduced sodium nitrate content (50 mg/kg) and fortified with freeze-dried currant leaf extract. Research indicates that employing a lyophilizate dose of 150 mg/kg yields optimal benefits in terms of the antioxidant activity of the meat product. Additionally, three highly promising sequences for canned meat were identified via analysis in the BIOPEP database. These sequences are RPPPPPPPPAD, exhibiting DPP-IV inhibiting activity; ARPPPGPPPLGPPPPGP, demonstrating ACE-I inhibiting activity; and PPGPPPPP, displaying alpha-glucosidase inhibiting activity. Using bioinformatics tools, molecular docking was performed by pairing the selected peptides with protein receptors 2QT9, 1O86, and 5NN8, respectively (PDB ID). The examination of the potential of these selected sequences to manifest specific biological activities toward enzymes was based on the free energy value (∆Gbinding). This knowledge can be harnessed for designing functional foods, thereby contributing to the safeguarding of consumer health.
Clinical Significance of Nutritional Status, Inflammation, and Body Composition in Elderly Hemodialysis Patients—A Case–Control Study
Authors: Ruperto Mar , Barril Guillermina
Published: December 2023

Nutritional and inflammatory disorders are factors that increase the risk of adverse clinical outcomes and mortality in elderly hemodialysis (HD) patients. This study aimed to examine nutritional and inflammation status as well as body composition in older adults on HD compared to matched controls. A case–control study was conducted on 168 older participants (84 HD patients (cases) and 84 controls) age- and sex-matched. Demographic, clinical, anthropometric, and laboratory parameters were collected from medical records. The primary outcome was nutritional status assessment using a combination of nutritional and inflammatory markers along with the geriatric nutritional risk index (GNRI). Sarcopenic obesity (SO) was studied by the combined application of anthropometric measures. Body composition and hydration status were assessed by bioelectrical impedance analysis (BIA). Univariate and multivariate regression analyses were performed to identify nutritional and inflammatory independent risk indicators in elderly HD patients and controls. A significantly high prevalence of nutritional risk measured by the GNRI was found in HD patients (32.1%) compared to controls (6.0%) (p < 0.001). Elderly HD patients were overweight and had lower percent arm muscle circumference, phase angle (PA), serum albumin (s-albumin), as well as higher percent extracellular body water (ECW%) and serum C-reactive protein (s-CRP) than controls (all at least, p < 0.01). SO was higher in HD patients (15.50%) than in controls (14.30%). By multi-regression analyses, age < 75 years (OR: 0.119; 95%CI: 0.036 to 0.388), ECW% (OR: 1.162; 95%CI: 1.061 to 1.273), PA (OR: 0.099; 95%CI: 0.036 to 0.271), as well as BMI, s-albumin ≥ 3.8 g/dL, and lower s-CRP were independently related between cases and controls (all at least, p < 0.05). Elderly HD patients had increased nutritional risk, SO, inflammation, overhydration, and metabolic derangements compared to controls. This study highlights the importance of identifying nutritional risk along with inflammation profile and associated body composition disorders in the nutritional care of elderly HD patients. Further studies are needed to prevent nutritional disorders in elderly HD patients.
Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis
Authors: Boachie Joseph , Zammit Victor , Saravanan Ponnusamy , Adaikalakoteswari Antonysunil
Published: December 2023

Background: Prolonged metformin treatment decreases vitamin B12 (B12) levels, whereas low B12 is associated with dyslipidaemia. Some studies have reported that metformin has no effect on intrahepatic triglyceride (TG) levels. Although AMP-activated protein kinase (AMPK) activation via adiponectin lowers hepatic TG content, its role in B12 deficiency and metformin has not been explored. We investigated whether low B12 impairs the beneficial effect of metformin on hepatic lipid metabolism via the AMPK-adiponectin axis. Methods: HepG2 was cultured using custom-made B12-deficient Eagle’s Minimal Essential Medium (EMEM) in different B12-medium concentrations, followed by a 24-h metformin/adiponectin treatment. Gene and protein expressions and total intracellular TG were measured, and radiochemical analysis of TG synthesis and seahorse mitochondria stress assay were undertaken. Results: With low B12, total intracellular TG and synthesized radiolabelled TG were increased. Regulators of lipogenesis, cholesterol and genes regulating fatty acids (FAs; TG; and cholesterol biosynthesis were increased. FA oxidation (FAO) and mitochondrial function were decreased, with decreased pAMPKα and pACC levels. Following metformin treatment in hepatocytes with low B12, the gene and protein expression of the above targets were not alleviated. However, in the presence of adiponectin, intrahepatic lipid levels with low B12 decreased via upregulated pAMPKα and pACC levels. Again, combined adiponectin and metformin treatment ameliorated the low B12 effect and resulted in increased pAMPKα and pACC, with a subsequent reduction in lipogenesis, increased FAO and mitochondrion function. Conclusions: Adiponectin co-administration with metformin induced a higher intrahepatic lipid-lowering effect. Overall, we emphasize the potential therapeutic implications for hepatic AMPK activation via adiponectin for a clinical condition associated with B12 deficiency and metformin treatment.
In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein
Authors: Baroni Debora , Scarano Naomi , Ludovico Alessandra , Brandas Chiara , Parodi Alice , Lunaccio Dario , Fossa Paola , Moran Oscar , Cichero Elena , Millo Enrico
Published: December 2023

Cystic fibrosis (CF), the most common autosomal recessive fatal genetic disease in the Caucasian population, is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel that regulates salt and water transport across a variety of secretory epithelia. Deletion of phenylalanine at position 508, F508del, the most common CF-causing mutation, destabilises the CFTR protein, causing folding and trafficking defects that lead to a dramatic reduction in its functional expression. Small molecules called correctors have been developed to rescue processing-defective F508del CFTR. We have combined in silico and in vitro approaches to investigate the mechanism of action and potential as CFTR correctors of three hybrid derivatives (2a, 7a, and 7m) obtained by merging the amino-arylthiazole core with the benzodioxole carboxamide moiety characterising the corrector lumacaftor. Molecular modelling analyses suggested that the three hybrids interact with a putative region located at the MSD1/NBD1 interface. Biochemical analyses confirmed these results, showing that the three molecules affect the expression and stability of the F508del NBD1. Finally, the YFP assay was used to evaluate the influence of the three hybrid derivatives on F508del CFTR function, assessing that their effect is additive to that of the correctors VX661 and VX445. Our study shows that the development and testing of optimised compounds targeting different structural and functional defects of mutant CFTR is the best strategy to provide more effective correctors that could be used alone or in combination as a valuable therapeutic option to treat an even larger cohort of people affected by CF.
Squalene Peroxidation and Biophysical Parameters in Acne-Prone Skin: A Pilot “In Vivo” Study
Authors: Condrò Giorgia , Sciortino Roberta , Perugini Paola
Published: December 2023

Nowadays, acne vulgaris therapies are often unsuccessful. One of the responsible factors for the formation of comedones and inflammatory lesions could be the peroxidation of squalene, a hydrocarbon representing one of the major components of human sebum. This peroxidation is increased by solar irradiation. The purpose of this work was to set up an in vivo method for the extraction and quantification of squalene from acne skin and to correlate the results with biophysical skin parameters such as sebum amount, protein content and TEWL. Healthy volunteers were used as control. The results obtained demonstrated that acne-prone skin had a major quantity of squalene, and, in the stratum corneum area, its peroxide form is present. Moreover, Spearman’s rank correlation showed a positive correlation between sebum content and peroxide squalene and between porphyrin intensity and peroxide squalene.
Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity
Authors: Jin Jin , Liang Xujun , Bi Wu , Liu Ruijie , Zhang Sai , He Yi , Xie Qingming , Liu Shilei , Xiao Ji-Chang , Zhang Pengfei
Published: December 2023

Fenofibrate is known as a lipid-lowering drug. Although previous studies have reported that fenofibrate exhibits potential antitumor activities, IC50 values of fenofibrate could be as high as 200 μM. Therefore, we investigated the antitumor activities of six synthesized fenofibrate derivatives. We discovered that one compound, SIOC-XJC-SF02, showed significant antiproliferative activity on human hepatocellular carcinoma (HCC) HCCLM3 cells and HepG2 cells (the IC50 values were 4.011 μM and 10.908 μM, respectively). We also found this compound could inhibit the migration of human HCC cells. Transmission electron microscope and flow cytometry assays demonstrated that this compound could induce apoptosis of human HCC cells. The potential binding sites of this compound acting on human HCC cells were identified by mass spectrometry-cellular thermal shift assay (MS-CETSA). Molecular docking, Western blot, and enzyme activity assay-validated binding sites in human HCC cells. The results showed that fumarate hydratase may be a potential binding site of this compound, exerting antitumor effects. A xenograft model in nude mice demonstrated the anti-liver cancer activity and the mechanism of action of this compound. These findings indicated that the antitumor effect of this compound may act via activating fumarate hydratase, and this compound may be a promising antitumor candidate for further investigation.
The Antioxidant Activity of Wild-Growing Plants Containing Phenolic Compounds in Latvia
Authors: Teterovska Renāte , Sile Inga , Paulausks Artūrs , Kovalcuka Liga , Koka Rudīte , Mauriņa Baiba , Bandere Dace
Published: December 2023

Ethnobotanical reports from Latvia show that Tanacetum vulgare, Calluna vulgaris, Quercus robur, Artemisa absinthium, and Artemisia vulgaris contain phenolic compounds that have antioxidant properties, which can be beneficial in the treatment and prophylaxis of many diseases. The aim of this study was to characterize the phenolic compounds and antioxidant properties of these plants. Plant extracts were prepared using ethanol or acetone and then freeze-dried. Their total phenolic content (TPC), total flavonoid content (TFC), and total tannin content (TTC) were determined and characterized by HPLC. Their antioxidant properties were determined using a DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. C. vulgaris herb and T. vulgare leaf extracts contained the highest amounts of flavonoids, but the bark of Q. robur had mostly tannins and phenolic acids. A. absinthium and A. vulgaris had the lowest amounts of polyphenols. When compared using extraction solvents, all acetone extracts had more TPC, more TFC, and better antioxidant activity. All plants contained chlorogenic acid, which contributes to antioxidant properties. The analysed plant extracts could be used in future studies to develop medicinal products with antioxidant properties.
The Oneness of Love in Works of Love
Authors: Hanson Jeffrey
Published: December 2023

Kierkegaard’s claim that God just is love implies that love is ultimately one reality. Indeed, on more than one occasion, Kierkegaard will make this point explicitly as well as implicitly by frequently asserting the oneness of love. For example, early on in Works of Love, he states plainly that “this love for the neighbor is not related as a type to other types of love. Erotic love is defined by the object; friendship is defined by the object; only love for the neighbor is defined by love”. What Kierkegaard means by this is that preferential loves are defined by a factor in addition to love itself: the object of that love. Neighbor-love is defined by love itself, which takes as its object the neighbor, or in other words, “unconditionally every human being”. Preferential loves are specified as it were by the person loved in this manner. Neighbor-love is not related as a type to other types of love in that neighbor-love is paradigmatic love; preferential loves are specified, but as recent commentators have shown, are not thereby precluded from also being or filtered by or infused by or coincident with neighbor-love as well. The point of this passage is that there are not distinct, enumerated types of love that, taken together, can be amalgamated into something called “love”, which would be inclusive of distinct kinds. The current paper argues that neighbor-love is meant to be thought of as paradigmatic. Therefore, as a paradigmatic unity, it will also exhibit qualities ordinarily associated with preferential love. Put differently, my claim is that we have reason to conclude that, in the end, features of preferential love will be manifest in neighbor-love just as surely as neighbor-love has an effect on preferential love. I wish to take seriously the claim of Works of Love that, ultimately, love is one. Love, being one, is not comprised of distinct types or subsets. I demonstrate the importance of this point by explaining how all love has its ultimate origin in God (and God just is love). While seemingly a truism, I argue from a variety of passages that the oneness of love has multiple implications throughout the text, implications that further support the theory that neighbor-love is not an alternative to, but rather encompasses features of, preferential loves.
Entering the Prophetic Realm: ʿAbd Rabbihī ibn Sulaymān al-Qaliyūbī (d. 1968) on the Nature of Mediation (tawassul)
Authors: Lützen Florian A.
Published: December 2023

In his comprehensive work Fayḍ al-wahhāb, ʿAbd Rabbihī ibn Sulaymān al-Qaliyūbī (d. 1968) extensively explores the Prophet Muhammad’s role in theology and argues against interpretations influenced by Wahhābī thought. He emphasizes the prophetic realm, or prophecy and its traces, particularly the means by which believers can establish a connection with it. This article pays special attention to al-Qaliyūbī’s understanding of mediation (tawassul); that is, how the Prophet—by virtue of his elevated status, ordained by God—can serve as a means; similar to how a ritual prayer or any good deed ultimately serves as a means to draw closer to God. For al-Qaliyūbī, following the Prophet means not only regarding him as the founder of the religion, but also incorporating his spirit and character into one’s own life. This article proceeds in four steps: (1) It addresses the systematics of prophecy concerning practical ethics and how this realm can be entered; (2) It introduces the three-layered paradigm of later theology and al-Qaliyūbī’s work; (3) It explores the topic of what constitutes a means (wasīla) and the theological implications of using a means in prayer (tawassul); (4) It zooms in on the aspect of what qualifies a means to be used in an individual prayer.
Juan Sepulveda and the Understanding of the Syncretic Characteristics of Latin American Pentecostalism: The Case of Classical Pentecostalism in Guatemala
Authors: Bom Klaas , Monroy-Soto Jonán
Published: December 2023

This article presents the case of Guatemalan Pentecostalism as a highly relevant expression of Latin American Pentecostalism that helps to clarify the debate about the syncretic nature of Pentecostalism. We use the Guatemalan case to test the thesis of Juan Sepúlveda, a Chilean Pentecostal historian and theologian, who explains the success of Latin American Pentecostalism in light of its syncretic character. His argument about the syncretic character of Pentecostalism is based on the Chilean case. Paying attention to its historical development, we present Guatemalan Pentecostal theology in relation to traditional Mayan culture and religion and in relation to popular Catholicism and traditional Latin American Protestantism. Specific attention is paid to the espoused theology of Pentecostal pastors as they provide an account of indigenous Pentecostals’ lived faith. Finally, we answer the question: Does Juan Sepulveda’s approach (still) provide an adequate framework for the theological assessment of possible syncretic characteristics of (Latin American) Pentecostalism? The Guatemalan case indicates ways to improve certain limitations of Sepúlveda’s approach, such as its static understanding of culture and its exclusion of the theological understanding of syncretism.
Evaluating the Performance of Mobile-Convolutional Neural Networks for Spatial and Temporal Human Action Recognition Analysis
Authors: Moutsis Stavros N. , Tsintotas Konstantinos A. , Kansizoglou Ioannis , Gasteratos Antonios
Published: December 2023

Human action recognition is a computer vision task that identifies how a person or a group acts on a video sequence. Various methods that rely on deep-learning techniques, such as two- or three-dimensional convolutional neural networks (2D-CNNs, 3D-CNNs), recurrent neural networks (RNNs), and vision transformers (ViT), have been proposed to address this problem over the years. Motivated by the fact that most of the used CNNs in human action recognition present high complexity, and the necessity of implementations on mobile platforms that are characterized by restricted computational resources, in this article, we conduct an extensive evaluation protocol over the performance metrics of five lightweight architectures. In particular, we examine how these mobile-oriented CNNs (viz., ShuffleNet-v2, EfficientNet-b0, MobileNet-v3, and GhostNet) execute in spatial analysis compared to a recent tiny ViT, namely EVA-02-Ti, and a higher computational model, ResNet-50. Our models, previously trained on ImageNet and BU101, are measured for their classification accuracy on HMDB51, UCF101, and six classes of the NTU dataset. The average and max scores, as well as the voting approaches, are generated through three and fifteen RGB frames of each video, while two different rates for the dropout layers were assessed during the training. Last, a temporal analysis via multiple types of RNNs that employ features extracted by the trained networks is examined. Our results reveal that EfficientNet-b0 and EVA-02-Ti surpass the other mobile-CNNs, achieving comparable or superior performance to ResNet-50.
Construction and Optimisation of Ecological Networks in High-Density Central Urban Areas: The Case of Fuzhou City, China
Authors: Geng Jianwei , Yu Kunyong , Sun Menglian , Xie Zhen , Huang Ruxian , Wang Yihan , Zhao Qiuyue , Liu Jian
Published: December 2023

Constructing and optimising ecological networks in high-density cities plays an important role in mitigating urban ecological problems. Our study uses comprehensive evaluation methods such as Morphological Spatial Pattern Analysis (MSPA), the Remote Sensing Ecological Index (RSEI), and Connectivity to identify ecological source areas in Fuzhou City, and constructs and optimises the network using the Minimum Cumulative Resistance (MCR) model, current theory, and other methods. Meanwhile, the changes in urban landscape connectivity under different development scenarios were explored. The results show that the following: (1) the identification of ecological source sites based on the integrated approach is better than the single MSPA method; (2) the ecological network of Fuzhou City consists of 44 ecological source sites and 92 corridors; and (3) among the various development modes, transforming the top 30% of the bare land patches in Fuzhou City into green spaces improves the overall connectivity of the ecological network the most. The results can provide auxiliary decision-making for ecological construction in high-density cities.
Detection of Changes in Buildings in Remote Sensing Images via Self-Supervised Contrastive Pre-Training and Historical Geographic Information System Vector Maps
Authors: Feng Wenqing , Guan Fangli , Tu Jihui , Sun Chenhao , Xu Wei
Published: December 2023

The detection of building changes (hereafter ‘building change detection’, BCD) is a critical issue in remote sensing analysis. Accurate BCD faces challenges, such as complex scenes, radiometric differences between bi-temporal images, and a shortage of labelled samples. Traditional supervised deep learning requires abundant labelled data, which is expensive to obtain for BCD. By contrast, there is ample unlabelled remote sensing imagery available. Self-supervised learning (SSL) offers a solution, allowing learning from unlabelled data without explicit labels. Inspired by SSL, we employed the SimSiam algorithm to acquire domain-specific knowledge from remote sensing data. Then, these well-initialised weight parameters were transferred to BCD tasks, achieving optimal accuracy. A novel framework for BCD was developed using self-supervised contrastive pre-training and historical geographic information system (GIS) vector maps (HGVMs). We introduced the improved MS-ResUNet network for the extraction of buildings from new temporal satellite images, incorporating multi-scale pyramid image inputs and multi-layer attention modules. In addition, we pioneered a novel spatial analysis rule for detecting changes in building vectors in bi-temporal images. This rule enabled automatic BCD by harnessing domain knowledge from HGVMs and building upon the spatial analysis of building vectors in bi-temporal images. We applied this method to two extensive datasets in Liuzhou, China, to assess its effectiveness in both urban and suburban areas. The experimental results demonstrated that our proposed approach offers a competitive quantitative and qualitative performance, surpassing existing state-of-the-art methods. Combining HGVMs and high-resolution remote sensing imagery from the corresponding years is useful for building updates.
Publish/Subscribe Method for Real-Time Data Processing in Massive IoT Leveraging Blockchain for Secured Storage
Authors: Ataei Mohammadhossein , Eghmazi Ali , Shakerian Ali , Landry Rene , Chevrette Guy
Published: December 2023

In the Internet of Things (IoT) era, the surge in Machine-Type Devices (MTDs) has introduced Massive IoT (MIoT), opening new horizons in the world of connected devices. However, such proliferation presents challenges, especially in storing and analyzing massive, heterogeneous data streams in real time. In order to manage Massive IoT data streams, we utilize analytical database software such as Apache Druid version 28.0.0 that excels in real-time data processing. Our approach relies on a publish/subscribe mechanism, where device-generated data are relayed to a dedicated broker, effectively functioning as a separate server. This broker enables any application to subscribe to the dataset, promoting a dynamic and responsive data ecosystem. At the core of our data transmission infrastructure lies Apache Kafka version 3.6.1, renowned for its exceptional data flow management performance. Kafka efficiently bridges the gap between MIoT sensors and brokers, enabling parallel clusters of brokers that lead to more scalability. In our pursuit of uninterrupted connectivity, we incorporate a fail-safe mechanism with two Software-Defined Radios (SDR) called Nutaq PicoLTE Release 1.5 within our model. This strategic redundancy enhances data transmission availability, safeguarding against connectivity disruptions. Furthermore, to enhance the data repository security, we utilize blockchain technology, specifically Hyperledger Fabric, known for its high-performance attributes, ensuring data integrity, immutability, and security. Our latency results demonstrate that our platform effectively reduces latency for 100,000 devices, qualifying as an MIoT, to less than 25 milliseconds. Furthermore, our findings on blockchain performance underscore our model as a secure platform, achieving over 800 Transactions Per Second in a dataset comprising 14,000 transactions, thereby demonstrating its high efficiency.
The Perceptions of Generation Z University Students about Their Futures: A Qualitative Study
Authors: Dikeç Gül , Öztürk Simge , Taşbaşı Neslihan , Figenergül Damla , Güler Bilal Buğrahan
Published: December 2023

This study explored the future-oriented perceptions of Generation Z students in a foundation university. This study was conducted using qualitative research and a phenomenological design. The study sample consisted of 11 university students over the age of 18 who agreed to participate in the study. Data were collected online through individual interviews in Türkiye. Colaizzi’s phenomenological analysis method was used in the data analysis. The content analysis determined three main themes and eleven sub-themes. The first theme was the students’ knowledge acquisition about the “current situation of the country.” Under this theme were four sub-themes: economic problems, the immigrant situation, the education and justice system, and the country’s agenda. In the second theme, students shared their opinions about “being a student in the country.” This theme included economic impossibilities, their participation in limited social activities, and housing problems. In the last theme, “future anxiety,” the sub-themes of the students were found to include experiences hopelessness versus hope. Uncertainty caused anxiety, as did going abroad, finding a job, and improving themselves. It was determined that the participants were worried about the current situation in the countries they lived in during this period due to economic problems; while some were hopeful about the future, some were hopeless and would go abroad. This study might contribute to the literature on determining the future-oriented perceptions, possible stressors and hope levels of Generation Z university students in Türkiye. Additionally, intervention programs can be developed for the management these stressors to protect the mental health of Generation Z university students. On the other hand, it is necessary to protect the mental health of young people, who are the adults of the future, and to create policies for the youth of this country where social opportunities are maintained.
Analyzing the Risk Factors of Hazardous Chemical Road Transportation Accidents Based on Grounded Theory and a Bayesian Network
Authors: Wang Huanhuan , Zhang Yong , Li Runqiu , Cui Yan , He Andan , Jiang Weiqing
Published: December 2023

With the increase in the production and use of hazardous chemicals in China, road transportation safety issues are becoming increasingly prominent. To study the causes of road transportation accidents involving hazardous chemicals, prevent accident occurrence, and realize the safety and sustainable development of the transportation of hazardous chemicals, we combined grounded theory (GT) and a Bayesian network (BN) model to quantify the causal relationship of the interactions among the influencing factors leading to hazardous chemical road transportation accidents that occurred in China in the period of 2017–2020. The influencing factors of these accidents were classified into 5 core categories, 12 main categories, and 28 categories through the GT method, and then a BN-based model was established for these collected accidents. The conditional probability and posterior probability of each influencing factor leading to an accident were determined through BN learning, and then the causal relationship of the interactions between the influencing factors was quantified. The results indicated that the probability of road transportation accidents involving hazardous chemicals considered in this study reaches 72.5% under the combined influence of various factors, and the most likely causal chain of an accident is that equipment failure during the hazardous chemical transportation process contributes to an Unsafe Tanker State, which in turn leads to an accident. The sensitivity analysis confirmed that the key impact factor of hazardous chemical road transportation accidents is equipment failure, followed by improper operation. Overall, this study presents a reference and a foundation for avoiding or reducing risks as much as possible during daily hazardous chemical road transportation operations and risk supervision, realizing safe, sustainable development.
Harnessing the Synergy of the Cyanobacteria-Plant Growth Promoting Bacteria for Improved Maize (Zea mays) Growth and Soil Health
Authors: Solomon Wogene , Mutum Lamnganbi , Rakszegi Mariann , Janda Tibor , Molnár Zoltán
Published: December 2023

Intensive use of chemicals in agriculture harms the soil, disrupts the ecological balance, and impacts microorganisms. Biofertilizers are gaining traction due to their eco-friendly and cost-effective benefits. This study evaluates the potential of the cyanobacterium MACC-612 (Nostoc piscinale) and plant growth-promoting bacteria (PGPB) (Azospirillum lipoferum, Pseudomonas fluorescens) in enhancing crop growth, yield, and soil health. A two-year field study was conducted using a factorial approach and a completely randomized block design, comprising four replications. The three levels of the cynobacterium (0, 0.3, or 1 g/L of N. MACC-612) and different bacteria strains were used in the experiments. The results demonstrated substantial enhancements in seed number per ear, kernel weight, and yield when using N. piscinale and PGPB, whether used individually or in combination. The soil pH, humus, (NO3− + NO2−)-nitrogen, and soil microbial biomass showed significant increases across both years. The combining application of the N. piscinale (0.3 g/L) with A. lipoferum increased grain yield by 33.20% in the first year and 31.53% in the second. The humus and (NO3− + NO2−)-nitrogen content significantly rose in treatments involving N. piscinale at 0.3 g/L combined with A. lipoferum at about 20.25% and 59.2%, respectively, in comparison to the untreated control. Hence, the most effective approach was the combined use of N. piscinale and A. lipoferum, which enhanced maize growth and soil fertility.
A Scientometric Analysis of Wellbeing Research in the Construction Industry
Authors: Samwinga Victor , Zulu Sambo , Adeyemi Toyin Ebenezer
Published: December 2023

The significance of wellbeing in the construction industry has increased due to the high frequency of accidents. However, the existing research fails to comprehensively address the various aspects of wellbeing. To address this gap, we conducted a literature review on wellbeing in the construction industry and carried out a trend analysis of its multiple dimensions. A systematic review of 162 peer-reviewed journal articles was performed using scientometric analysis and qualitative trend analysis techniques. The results indicated that the discussion on wellbeing in the construction industry tends to overlook its multifaceted nature. Prominent publication outlets were identified, with a focus on environmental and physical wellbeing, while recognising notable contributions in the field of mental wellbeing and the limited contributions to other dimensions of wellbeing. This study offers valuable insights for both researchers and industry practitioners. Researchers can identify priority areas for future research based on the identified gaps, while construction companies can gain awareness of the potential relevance of wellbeing in the industry. This study contributes to the existing knowledge on wellbeing in the construction industry by analysing its various dimensions and providing research directions. It serves as a reference point for interpreting findings and offers guidance for future research endeavours.
Spatiotemporal Evolution and Influencing Factors of Tourism Economic Resilience under the Impact of COVID-19—A Case Study of Coastal Cities in China
Authors: Cai Xiaolin , Xu Yilun
Published: December 2023

The COVID-19 pandemic has had a significant impact on the economic operations of many cities worldwide. Because tourism depends on migratory qualities, it has been severely constrained by the pandemic, which has affected the tourism business in several places. The research period for this paper is 2019–2021, and a comprehensive analysis of the spatiotemporal evolution pattern and influencing factors of the tourism economic resilience of China’s coastal cities is conducted using the resistance index, Theil index, spatial autocorrelation analysis, and geographic detector model with the goal of deepening the theory of tourism economic resilience and providing a reference for the sustainable development of tourism. The results revealed several trends. First, in terms of temporal changes, the fluctuation trend of tourism’s economic resilience in each city before and after the pandemic had a certain degree of stability and convergence, with only a few cities showing significant differences in their amplitude of fluctuations in 2021. Second, in the spatial pattern, the regions with high resilience and relatively high resilience were mainly concentrated in the western, northeastern, and eastern regions, and the northeastern-eastern regions with relatively high resilience were gradually developed in the agglomeration and a contiguous pattern. Third, the influencing factors of tourism’s economic resilience before and after the pandemic, despite differences, are still largely affected by the combined influence of the city’s economic level, industrial structure, tourism resource endowment, and other factors.
An Empirical Analysis of the Impact of Brand Story Themes on Brand Attitude in the Context of B2C E-Commerce Platforms for Organic Agricultural Products
Authors: Zhang Jing , Liu Ziyang
Published: December 2023

Against the background of B2C e-commerce platforms, ecological agricultural enterprises often overlook the issues of quality and safety, as well as product image shaping, during their operations, thereby affecting consumers’ purchase decisions. This study adopted authoritative scales and utilized data from 201 questionnaires to empirically investigate the influence of brand images on brand attitudes. Firstly, variables of consumers’ perception and brand attitude were measured through questionnaires. Secondly, regression models were used to discuss the impacts of different brand storytelling themes on brand attitudes. Finally, models of the mediating and moderating effects were employed to empirically study the mechanisms of consumers’ perception and regional familiarity. The research results indicate that brand storytelling themes of ecological agricultural products have a significant positive impact on consumers’ brand attitudes. Consumers’ perception of authenticity plays a mediating role, while regional familiarity acts as a moderator. The research conclusions enrich brand evaluation systems, deepen the related research on brand storytelling themes of agricultural products, reveal the inherent mechanism of the influence of brand storytelling themes of ecological agricultural products on consumers’ brand attitudes, and provide a reference for the practice of regional brand narratives of agricultural products.
An Analytical Study Predicting Future Conditions and Application Strategies of Concrete Bridge Pavement Based on Pavement Management System Database
Authors: Lee Jinhyuk , Jung Donghyuk , Baek Cheolmin , An Deoksoon
Published: December 2023

South Korea is implementing various policies to address the aging of infrastructures and improve road infrastructure management. Moreover, numerous research projects aiming at the development of necessary technologies for the proper implementation of these policies are underway. This study specifically aims to overcome existing problems in bridge pavement maintenance, such as the inaccuracy of future condition predictions and the selection of incorrect evaluation indicators. Our goal is to provide a new approach for the improved management of the bridge pavement management system (BPMS). To address the issues of accuracy in future condition prediction and evaluation indicator selection within the existing maintenance system, we utilized particle filtering, a Kalman filter method among machine learning techniques. This method allows for the prediction of future conditions, based on the nonlinearly collected bridge pavement conditions within BPMS. Furthermore, we proposed a systematic bridge pavement management strategy. This strategy utilizes traffic volume (ESALs; equivalent single axle loadings), a factor that can influence the future condition of bridge pavement, in correlation with the future condition predicted through particle filtering within BPMS.
Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review
Authors: Safarpour Delaram , Jabbari Bahman
Published: December 2023

This systematic review investigates the effect of botulinum neurotoxin (BoNT) therapy on cancer-related disorders. A major bulk of the literature is focused on BoNT’s effect on pain at the site of surgery or radiation. All 13 published studies on this issue indicated reduction or cessation of pain at these sites after local injection of BoNTs. Twelve studies addressed the effect of BoNT injection into the pylorus (sphincter between the stomach and the first part of the gut) for the prevention of gastroparesis after local resection of esophageal cancer. In eight studies, BoNT injection was superior to no intervention; three studies found no difference between the two approaches. One study compared the result of intra-pyloric BoNT injection with preventive pyloromyotomy (resection of pyloric muscle fibers). Both approaches reduced gastroparesis, but the surgical approach had more serious side effects. BoNT injection was superior to saline injection in the prevention of esophageal stricture after surgery (34% versus 6%, respectively, p = 0.02) and produced better results (30% versus 40% stricture) compared to steroid (triamcinolone) injection close to the surgical region. All 12 reported studies on the effect of BoNT injection into the parotid region for the reduction in facial sweating during eating (gustatory hyperhidrosis) found that BoNT injections stopped or significantly reduced facial sweating that developed after parotid gland surgery. Six studies showed that BoNT injection into the parotid region prevented the development of or healed the fistulas that developed after parotid gland resection—parotidectomy gustatory hyperhidrosis (Frey syndrome), post-surgical parotid fistula, and sialocele. Eight studies suggested that BoNT injection into masseter muscle reduced or stopped severe jaw pain after the first bite (first bite syndrome) that may develop as a complication of parotidectomy.
TO THE PROBLEM OF DUALISM IN THE LYRICS OF F.I. TYUTCHEV
Authors:   Orel State University, GRIGORIEVA T.I. , KOVALEVA T.V. ,   Orel State University
Published: December 2023

The article discusses the features of the character of F.I. Tyutchev, the contradictions that were characteristic of his nature. Fragments of the poet’s letters, memories of him are given, in which the complex spiritual world of F.I. Tyutchev, his inner split, which largely explains the dualism in the poet’s lyrics.
THE IMAGE OF ST. PETERSBURG IN THE PROSE OF M.M. PRISHVIN AND N.N. TOLSTOY
Authors:   Orel State University, SMOGOL N.N. , BAZHENOVA K.E. ,   Orel State University
Published: December 2023

The article discusses epic works of a small genre dedicated to the image of St. Petersburg (in Soviet times Leningrad) and created by M.M. Prishvin and N.N. Tolstaya. The basis of the comparative analysis is the traditions of the depiction of this significant city for the national history by Russian writers and poets.
TRAINING OF MEDICAL STUDENTS IN INTERACTIVE VISUALIZATION OF RESEARCH RESULTS
Authors:   Orel State University, AVDEEV I.F. , VASHUNIN A.A. ,   Orel State University, SAVATEEVA E.S. ,   Orel State University
Published: December 2023

Currently, medical research requires not only mathematical processing ofthe results, but also their correct presentation and submission to the audience. The demonstration of tables containing several thousand rows does not carry enough informative load, slows down the perception of the facts presented by the researcher and analysis of results. Therefore, it is so important to teach future specialists to analyze the possibilities of presenting existing data and correctly visualize the result.
MORAL EDUCATION OF YOUNGER SCHOOLCHILDREN IN INSTITUTIONS OF SOCIO-CULTURAL SPHERE THROUGH MULTI- AND VIDEO CONTENT
Authors:   Oryol State lnstitute of Culture, DOMARENKO E.V. , STEPANCHENKO O.V. ,   Oryol State lnstitute of Culture
Published: December 2023

The article deals with the problem of moral education of younger schoolchildren. The authors emphasize the role of pedagogical influence through cartoon content in the formation of the moral image of younger schoolchildren. The relevance of this approach is due to the aggressiveness and blurring of the pedagogical potential of modern video culture and cartoon content, which have a negative impact on the moral and mental health of younger schoolchildren. The success of solving this problem is seen in the integration of the educational capabilities of various social institutions, including institutions of the socio-cultural sphere, which possess methods of using the capabilities of multicontent in the moral education of younger schoolchildren.
ENGINEERING AND CREATIVE FIELD AS A MEDIUM FOR THE FORMATION OF PROFESSIONAL COMPETENCE OF AN ARTIST-STYLIST
Authors:   Orel State University, KARPEEVA S.A.
Published: December 2023

This article examines the engineering and creative field as an environment for the formation of professional competence in the context of engineering and technical design in the direction of training 54.03.03 The art of costume and textiles. The professional requirements for a university graduate are considered.
TRAINING OF MEDICAL STUDENTS IN INTERACTIVE VISUALIZATION OF A POPULATION STUDY OF CHILDREN'S HEALTH BY MEANS OF INFORMATION TECHNOLOGIES
Authors:   Orel State University, MEDVEDEV A.I. , PLYUSHCHEV A.A. ,   BUZ of the Oryol region «Oryol Regional Clinical Hospital», RUSAKOVA V.N. ,   Orel State University
Published: December 2023

In modern conditions, the accumulation of a large amount of medical data and their further processing becomes a necessity for researchers in this field of knowledge. Therefore, preparing students for professional activities implies not only the study of special disciplines, but also the ability to work with data using the capabilities of information technology. An essential point is also the practical orientation of training, which allows demonstrating to future doctors the real need to master such technologies to solve real problems.
MUSEUM PEDAGOGY AND ITS CREATIVE POTENTIAL IN A MULTICULTURAL SOCIETY
Authors:   Sevastopol State University, MILOKUMOV S.A. , CHVALA M.S. ,   V. I. Vernadsky Crimean Federal University
Published: December 2023

The article considers the pedagogical significance of museums, their influence on the level of education and culture of the population, the possibility of translating the past into the present through individual and public awareness, allowing through sensory perception to preserve the historical memory and intercultural communication. Possibilities offormation of harmonious interethnic relations, civic-patriotic qualities of youth, their holistic world outlook by means of museum pedagogy are studied. Attention is paid to the necessity of searching for new museum practices, allowing to create favorable conditions for educational activity.
PRACTICEOFPEDAGOGICALSYNERGETICS: EXPERIENCE OF SIMULATION OF EDUCATIONAL TECHNOLOGIES
Authors:   Secondary School Generation, SUKIASYAN A.M.
Published: December 2023

The algorithms of modeling pedagogical activity, which are based on a synergetic approach, are considered. The study was conducted in order to determine the degree of influence of the synergy of interaction of various educational technologies on the effectiveness of personality-oriented learning. It is shown that the construction of pedagogical activity, which is based on the synergy of interaction of diverse methodological techniques, ensures the advanced formation of needs for the development and acquisition of knowledge.
THE ROLE OF FIELD RESEARCH IN THE FORMATION OF SCIENTIFIC THINKING AMONG STUDENTS OF NATURAL SCIENCES
Authors:   Orel State University, CHAADAEVA N.N. , TROFIMETS L.N. ,   Orel State University
Published: December 2023

The article examines the role of students’ research work under the guidance of a university teacher, using the example of seasonal field research, using interdisciplinary connections within the framework of natural science training areas for the formation and development of a number of universal competencies among students that contribute to scientific thinking and professional literacy.
HISTORICAL OVERVIEW OF THE PARTICIPATION OF THE POPULATION IN THE FIELD OF FIRE SAFETY IN THE SECOND HALF OF THE 20TH CENTURY
Authors:   Plekhanov Russian University of Economics, GORLOVA N.I.
Published: December 2023

The article presents a historical overview of the voluntary participation of the population in the field of ensuring primary fire safety measures under the auspices of the All-Russian Voluntary Fire Society (VDPO) in the second half of the 20th century. The focus of the study is on the activities of activists and voluntary public figures of the Moscow City Volunteer Fire Society (MGDPO). Special attention is paid to the formation of voluntary firefighting units for children and adolescents.
N.M. ZERNOV AND HIS ROLE IN THE DEVELOPMENT OF DIALOGUE ROC AND CHURCH OF ENGLAND IN 1920-1940-KH
Authors:   Srednerussky Institute of Management - Branch of Russian Presidential Academy of National Economy and Public Administration, FEDOTOV S.P.
Published: December 2023

The article analyses the activities of the scholar, theologian N.M. Zernov. His personality occupies an important place in the development of Orthodox-Anglican dialogue in the 1920s and 1940s. N.M. Zernov was active in the Christian student movement in the 1920s. On N.M. Zernov’s initiative, the Commonwealth of St Albanius and St Sergius was established. The main task of the Commonwealth was mutual study of the ROC and the Church of England.