bluuebunny/crossref_metadata_2025 huggingface dataset:
Custo de produção da cultura da soja sob manejos de fitopatógenos e doses de boro
Authors: Silva Marco Antônio da , Silva Reiner Pimenta da , Souza Epitácio José de , Bertotti Jalel Augusto Algeri , Nuñez Daniel Noe Coaguila
Published: December 2022

A soja (Glycine max (L.) Merr.) é uma das culturas de maior importância econômica no mundo, e o Brasil é o maior produtor mundial desse grão. A produtividade da cultura é definida principalmente pela interação da planta com ambiente e manejo, principalmente o manejo fitossanitário e o nutricional. Assim, objetivou-se avaliar os custos de produção e seus efeitos na produtividade sobre os métodos de consórcio de produtos químicos ou biológicos para o manejo de fitopatógenos, em função de doses de Boro aplicado na dessecação e/ou aplicado posterior suplementação em R1 (início da floração). O experimento foi instalado sob sistema de plantio direto, na Fazenda Rio Verdinho Três Barras, Rio Verde, Goiás, Brasil, no período de Outubro 2021 a Março de 2022, com espaçamento de 0,45 m utilizando a cultivar de soja DM 68i69 IPRO, recomendada para a região. O delineamento experimental utilizado foi em blocos casualizados, com 11 tratamentos e quatro repetições. Os tratamentos consistiram em 2 manejos fitossanitários (tratamento de sementes com produtos biológicos e tratamento padrão da maioria dos produtores do Sudoeste Goiano) para o controle de fitopatógenos e 5 doses de Boro (0; 0,25; 0,50;0,75 e 1,0 L ha-1) aplicada na dessecação e/ou aplicado posterior suplementação em R1. Ao final, foram avaliados a produtividade final e os custos de produção. Os dados foram submetidos à análise de variância pelo teste de F com p < 0,05 e as médias foram comparadas pelo teste Duncan com p < 0,05. Para estimar o custo de produção, foi utilizado a estrutura de custo operacional total de produção, proposto pelo Instituto de Economia Agrícola – IEA. Maiores aplicações de Boro na dessecação nas doses 1 L ha-1 ou 0,75 L ha-1 e menores doses de Boro no estágio R1 aumenta significativamente a produtividade dos grãos de soja. Os tratamentos testados não influenciaram o custo operacional total (COT), o custo operacional total relativo (COEr), a receita bruta (RB), o lucro operacional efetivo (LOE), o lucro operacional total (LOT), a lucratividade, bem como a estimativa de produção e estimativa de equilíbrio. A estimativa do COT da soja cultivada em Rio Verde, Goiás, Brasil, foi de R$ 10.616,52 ha-1 com produtividades de até 95 sacas ha-1.
Knowledge, Attitudes and Practices about Cardiovascular Diseases among Adult Patients Attending Public Health Centers in Kigali city, Rwanda
Authors: Nyagasare Leonard Ntwari , Muvandimwe Emmanuel , Habtu Micheal , Rutayisire Erigene
Published: December 2022

In Rwanda, CVDs accounts around 14% of all death. Studies on knowledge, attitude, and practice (KAP) would be of great value in helping public health professionals develop targeted programs and measure the effectiveness of interventional programs. The main objective of this study was to analyze the KAP about CVDs among adult patients attending public health centers located in the City of Kigali, Rwanda. A total of 384 adult patients were enrolled in this study. A structured questionnaire was used. Data entry and analysis was done using SPSS version 21. Findings were presented as frequencies and percentages in tables. For determining the KAP-levels, the overall scores were determined for each respondent by adding up the scores through the KAP-related questions. The mean age was 36.4 years, primary school (57.3%), married (62.8%), self-employed (40.9%), and females predominated (61.5%). The knowledge mean score was 14.2 and 76% had high level of knowledge of CVD risks and prevention. The average attitude score for all respondents was 17.6 and 22.9% of the respondents showed negative attitude towards CVDs prevention. Research findings revealed that 36.5 % were not practicing physical activity and exercise. The mean practice score for all respondents was 3.9 and 70% of respondents had negative practice towards CVDs prevention. Poor CVDs prevention practices were observed among the study participants. Therefore, it is necessary to establish more effective educational interventions intended to promote positive health behaviors related CVD prevention
GIS, GPS AND REMOTE SENSING APPLICATION TO INVESTIGATE AGRICULTURAL POTENTIAL IN CHOLISTAN
Authors: Ahmad Farooq
Published: December 2022

Agriculture plays the most important part in the economy of our country from macro perspective,

while an equally important part in our social setup from a micro perspective. The ecological

system of Cholistan desert is highly delicate and has gone under tremendous changes brought

upon by physical and mainly by human interventions. The rapid development and integration

of spatial technologies such as Geographic Information System, Global Positioning System,

and Remote Sensing, have created many new tools for professionals, but have also widened

the "digital divide", leaving many with little understanding of the technology and potential

applications. Remote sensing can provide valuable, timely and even predicted information

about environment as an important basis for sustainable development. Geographic Information

System can provide effective tools for decision makers. The uses of GIS, GPS, and RS technologies,

either individually or in combination, span a broad range of applications and degrees

of complexity. It facilitates cooperative approaches and with the integration of GIS, there will

be a whole new framework for organizations and society to work together and make decisions.

However, an integrated GIS based database management system handles this highly significant

task to make our country more prosper among Nations.
Introducing Construction Semantics (CxS): a frame-semantic extension of Construction Grammar and constructicography
Authors: Willich Alexander
Published: December 2022

Construction Semantics (CxS) uses FrameNet frames to capture the semantic properties of grammatical constructions. It closes a gap between Frame Semantics and usage-based Construction Grammar as well as providing a uniform format to implement frames into constructicographic work. This article provides an overview of three core features of CxS. Starting point is (i) the modeling of semantic properties associated with constructions in terms of three types of frames. This makes possible (ii) the analysis of structural parallels between constructions and frames, in particular the semantic motivation of elements of a construct by frame elements. Lastly, (iii) an inventory of semantic parameters of constructions serves as a toolkit for generalizing over semantic properties of single constructs. A driving force behind CxS is the concept of frame proximity: a network of frames which allows one to distinguish lexically evoked frames that are related or unrelated to a frame associated with a construction.
Thermal transport with nanoparticles of fractional Oldroyd-B fluid under the effects of magnetic field, radiations, and viscous dissipation: Entropy generation; via finite difference method
Authors: Asjad Muhammad Imran , Usman Muhammad , Kaleem Muhammad Madssar , Baleanu Dumitru , Muhammad Taseer
Published: December 2022

It is a well-known fact that functional effects like relaxation and retardation of materials, and heat transfer phenomena occur in a wide range of industrial and engineering problems. In this context, a mathematical model is developed in the view of Caputo fractional derivative for Oldroyd-B nano-fluid. Nano-sized particles of copper (Cu) are used to prepare nano-fluid taking water as the base fluid. The coupled non-linear governing equations of the problem are transformed into dimensionless form. Finite difference scheme is developed and applied successfully to get the numerical solutions of deliberated problem. Influence of different physical parameters on fluid velocity profile and temperature profile are analyzed briefly. It is observed that for increasing values of fractional parameter (α), fluid velocity increased, but opposite behavior was noticed for temperature profile. Nusselt number (Nu) decayed for advancement in values of heat source/sink parameter (Q
0), radiation parameter (Nr), volume fraction parameter of nano-fluid (ϕ), and viscous dissipation parameter (Ec). Skin friction (C
f) boosts for the increase in the values of magnetic field parameter (Ha). It can also be noticed that the extended finite difference scheme is an efficient tool and gives the accurate results of discussed problem. It can be extended for more numerous type heat transfer problems arising in physical nature with complex geometry.
The treatment lottery of chronic back pain? A case series at a multidisciplinary pain centre
Authors: Mattsson Anna , Ghafouri Nazdar , Bäckryd Emmanuel
Published: December 2022

Objectives

Despite the number of people affected by chronic back pain, and the many available treatment options, even the best modalities provide limited pain reduction on a group level, often without simultaneous improvements in functioning or health-related quality of life. The objective was to provide an overview of the treatment of chronic back pain in clinical practice at a multidisciplinary pain centre, and to study patient and pain characteristics in different treatment groups.

Methods

104 chronic back pain patients (primary ICD-10-SE-diagnosis M53.0–M54.9 excluding M54.1 and M54.3), referred to the Pain and Rehabilitation Centre, University Hospital, Linköping in 2015, were studied using data from the Swedish Quality Registry for Pain Rehabilitation, self-reported medication data, and a retrospective medical record review.

Results

The following treatment groups were identified: rehabilitation (n=21), analgesics (n=33), invasive intervention (n=14), and no treatment (n=35). Significant differences between groups were found with regards to age, sick leave, education level, persisting pain duration, punishing responses by significant other, previous invasive intervention, receiving sub-clinic, physician speciality and referring care level.

Conclusions

Overall, patient demographics were associated with treatment strategy to a higher degree than patient-reported outcome measures. Moreover, physician speciality and organisational factors seemed to play a role in treatment choice.
Emotional Memory Processing during REM Sleep with Implications for Post-Traumatic Stress Disorder
Authors: Rho Young-Ah , Sherfey Jason , Vijayan Sujith
Published: December 2022

REM sleep is important for the processing of emotional memories, including fear memories. Rhythmic interactions, especially in the theta band, between the medial prefrontal cortex (mPFC) and limbic structures are thought to play an important role, but the ways in which memory processing occurs at a mechanistic and circuits level are largely unknown. To investigate how rhythmic interactions lead to fear extinction during REM sleep, we used a biophysically based model that included the infralimbic cortex (IL), a part of the mPFC with a critical role in suppressing fear memories. Theta frequency (4–12 Hz) inputs to a given cell assembly in IL, representing an emotional memory, resulted in the strengthening of connections from the IL to the amygdala and the weakening of connections from the amygdala to the IL, resulting in the suppression of the activity of fear expression cells for the associated memory. Lower frequency (4 Hz) theta inputs effected these changes over a wider range of input strengths. In contrast, inputs at other frequencies were ineffective at causing these synaptic changes and did not suppress fear memories. Under post-traumatic stress disorder (PTSD) REM sleep conditions, rhythmic activity dissipated, and 4 Hz theta inputs to IL were ineffective, but higher-frequency (10 Hz) theta inputs to IL induced changes similar to those seen with 4 Hz inputs under normal REM sleep conditions, resulting in the suppression of fear expression cells. These results suggest why PTSD patients may repeatedly experience the same emotionally charged dreams and suggest potential neuromodulatory therapies for the amelioration of PTSD symptoms.

SIGNIFICANCE STATEMENTRhythmic interactions in the theta band between the mPFC and limbic structures are thought to play an important role in processing emotional memories, including fear memories, during REM sleep. The infralimbic cortex (IL) in the mPFC is thought to play a critical role in suppressing fear memories. We show that theta inputs to the IL, unlike other frequency inputs, are effective in producing synaptic changes that suppress the activity of fear expression cells associated with a given memory. Under PTSD REM sleep conditions, lower-frequency (4 Hz) theta inputs to the IL do not suppress the activity of fear expression cells associated with the given memory but, surprisingly, 10 Hz inputs do. These results suggest potential neuromodulatory therapies for PTSD.
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis
Authors: Islam Md Saiful , Hardwick Steven W , Quell Laura , Durica‐Mitic Svetlana , Chirgadze Dimitri Y , Görke Boris , Luisi Ben F
Published: December 2022

Biogenesis of the essential precursor of the bacterial cell envelope, glucosamine‐6‐phosphate (GlcN6P), is controlled by intricate post‐transcriptional networks mediated by GlmZ, a small regulatory RNA (sRNA). GlmZ stimulates translation of the mRNA encoding GlcN6P synthtase in Escherichia coli, but when bound by RapZ protein, the sRNA becomes inactivated through cleavage by the endoribonuclease RNase E. Here, we report the cryoEM structure of the RapZ:GlmZ complex, revealing a complementary match of the RapZ tetrameric quaternary structure to structural repeats in the sRNA. The nucleic acid is contacted by RapZ mostly through a highly conserved domain that shares an evolutionary relationship with phosphofructokinase and suggests links between metabolism and riboregulation. We also present the structure of a precleavage intermediate formed between the binary RapZ:GlmZ complex and RNase E that reveals how GlmZ is presented and recognised by the enzyme. The structures provide a framework for understanding how other encounter complexes might guide recognition and action of endoribonucleases on target transcripts, and how structured substrates in polycistronic precursors may be recognised for processing by RNase E.
Pretreatment and cooking of forest residues
Authors: Wojtasz-Mucha Joanna , Mattsson Cecilia , Hasani Merima , Theliander Hans
Published: December 2022

The aim of this work was to investigate the possibility of processing forest residues by chemical delignification preceded by mild steam explosion. The focus was on using soda pulping, due to its simplicity. Kraft cooking was used for comparison to improve the understanding of the separation of the complex yet promising resource. The raw material consisted of chipped branches, bark, and twigs of mixed hardwood and softwood. Analysis of the raw material proved to be challenging due to the presence of a substantial fraction of extractives. Analysis of the pulps showed that the forest residue delignification was faster than that of wood. The effects of steam explosion were evaluated with the help of composition analysis, gel permeation chromatography (GPC) for the molecular weight of lignin, and NMR for the changes in its structure. The impact of steam explosion was found to be limited, possibly due to the relatively small size of the material.
Immersion between Semiotic Theories
Authors: Melnikova Irina
Published: December 2022

The paper focuses on the book of poetry immersion (2017) by Lithuanian poet Gytis Norvilas, maps the strategies of its reading within the framework of the semiotic-pragmatic approach, and considers the theoretical issues of the mapping. Despite the book cannot be unambiguously defined as an example of patterned poetry, it is configured in a specific way which exposes the functionality of the structural visual layer in written / printed poetry. This feature of the text in question inspires to revise the interpretation of the issue of iconicity and the configuration of the model of reading literature, proposed by the semiotic-pragmatic approach. The semiotic-pragmatic modelling combines Peircean and Jakobsonian ideas with minor insertions of Lotmanian thought (i.e. Johansen 2002), thus it links the ideas from the conceptual systems, based on different epistemological grounds (Peircean vs Saussurean notion of sign). It creates theoretical tensions that force to raise the question of how the transference of notions from one system to another changes their meaning, and where one could find the basis for overcoming or bypassing the controversies. The first part of the paper explores the theoretical tensions between Peircean, Jakobsonian and Lotmanian approaches to the issues of iconicity and attempts at revealing the fields of theoretical reasoning that help to define the ground of contradictions and see the way of their bypassing. Besides, it relates the discussion of iconicity with a discussion of the semiotic-pragmatic model of reading as iconization, based on the Jakobsonian idea of intersemiotic translation, and revises the model concerning the printed poetic text. The second part of the paper exemplifies the theoretical issues in the analysis of the book of poetry immersion. It examines the process of diagrammatization – the reading strategy, which makes the syntax of the text and that of the book the meaning-making devices, shows how diagrammatization semantizes the structure of the book, transforms the process of imaginization, and helps to identify the role of the book’s dialogue with hypotext to which both intertextual references and the structure of the text refer.
Phenotypic characterization of biofilm formation and efflux pump activity in multi-drug resistant staphylococcus species isolated from asymptomatic students
Authors: Nzube Favour Ekpunobi , Adeyemi Isaac Adeleye
Published: December 2022

Staphylococcus spp. are one of the major groups of bacterial commensals isolated from skin and mucous membranes. While a variety of Staphylococcal species are present on or in clinically normal individuals, some are also opportunistic pathogens and leading causes of community associated diseases in humans and animals worldwide. The objective of the study was to determine the antimicrobial susceptibility pattern, biofilm formation capability and efflux pump activity in Staphylococcus spp. isolated from nares and armpits of students. A total of 91 swab samples were collected from consenting microbiology students. Characterization of isolates was done using conventional microbiological guidelines yielding 50 Staphylococcal isolates and antimicrobial susceptibility was done following CLSI guidelines. Biofilm formation was detected using the congo red agar method and efflux activity was assayed by a modification of the EtBr cart wheel method using local blue dye. Among the 50 staphylococcal isolates, 7(14%) were coagulase positive while 43(86%) were coagulase negative. Antimicrobial susceptibility pattern of isolates showed resistance of 46(92%) to augmentin, 45(90%) to cloxacillin, 43(86%) to erythromycin, 41(84%) to cefuroxime and 39(78%) to ceftazidime. Resistance to gentamicin and oflaxacin was observed in only 5(10%) of the isolates. Biofilm formation (blackening of medium) was observed in 10(36%) of the 28 multi-drug resistant isolates and 5(83%) of the 6 isolates screened positive for efflux activity (non-retention of blue dye). Biofilm formation and efflux activity have shown to be mechanisms for drug resistance in community-associated staphylococcal isolates with high multi-drug resistance pattern.
The importance of habits in student life: results and consequences
Authors:   Ukranian Adventist Theological Institute, Koreshuk I.I. , Shpak D.O. ,   Ukrainian Institute of Arts and Sciences, Zubchuk A. ,   Ukrainian Institute of Arts and Sciences
Published: December 2022

The relevance of the research topic lies in the daily practical component of the stated problem. The topic of habits, particularly in student life, is important, because this component affects the professional development of a future specialist. Currently, time management is one of the promising areas of scientific research in recent years. Multi-functionality in the modern world has become a basic requirement for an employee with the massive emergence of information technologies in the era of digitalization. Since the work efficiency of any employee depends on previously acquired skills, it makes sense to investigate the peculiarities of becoming a specialist during the student period. In particular, this concerns the issue of habit formation. The research presents the results of the author’s questionnaire. In particular, a chart of respondents’ answers regarding their age, type of activity, gender, etc. general personality parameters. Based on the respondents’ answers, it was determined whether, in their opinion, habits are an important part of life. Reflections on whether habits can significantly improve or worsen life, and whether they are capable of forming a person’s character, are highlighted. Particular attention is focused on whether habits can be an important factor in student life, as well as on what type of habits prevail in their lives. Currently, a certain number of students do not fully understand the importance of habits with all their consequences. Therefore, it is important to investigate how these habits can affect life and in what way. The results and consequences of the student’s habits have meaning, depending on their beneficial or negative impact. Much depends on the ability to acquire and get rid of various habits. That is why the outline of the problems of the importance of habits in student life and the definition of the accepted connotation for the people of the XXI century. is an actual scientific direction. The article focuses on the definition of types of habits and their impact on a student’s life. The methods of acquiring, losing and consolidating habits in student life have been studied. The main categories on the path to successful habit formation are highlighted, including purpose, simplicity, attractiveness, visibility and satisfaction, and the need to monitor the progress of habits.
The potential of catestatin in the diagnostics of cardiovascular diseases: current data and perspectives
Authors:   Kharkiv medical academy of postgraduation education, Pankova O.
Published: December 2022

Cardiovascular diseases are not only the most common non-communicable diseases, but also occupy the leading place in the structure of total mortality in the world population. Among the wide range of pathogenetic mechanisms of the above-mentioned pathology, an increase in the activity of the sympathetic nervous system should be marked, given that catestatin, known primarily for its ability to inhibit hyperactivation of the sympathetic nervous system, deserves special attention. This article considers the issue of the diagnostic potential of catestatin in the management of cardiovascular pathology. The literature analysis made it possible to determine the dynamics of catestatin levels during the development of coronary heart disease and heart failure. The established correlations of catestatin with other cardiovascular biomarkers, such as NT-proBNP, sST2, hscTnI, allow us to note its potential place in the diagnosis of cardiovascular pathology. The results of numerous clinical studies demonstrated the correlation between catestatin levels and the development of complications, including the level of mortality, which allows considering catestatin as a predictor of the development of complications of cardiovascular diseases. Therefore, the prognostic value of catestatin levels in patients with coronary heart disease and heart failure allows it to be considered a marker of these diseases.
Diabetic dyslipidemia: focus on pathogenesis and treatment
Authors:   Kharkiv National Medical Univercity, Zhuravlyova L.V. , Sokolnikova N.V. ,   Kharkiv National Medical University, Rogachova T.A. ,   Kharkiv National Medical University
Published: December 2022

Atherosclerotic cardiovascular diseases are the most common cause of death in the developed countries of the world. Patients with diabetes mellitus 2 type are 2-4 times more likely to die from these diseases compared to patients without diabetes. This review discusses the pathophysiology of lipid disorders, which are the main cause of cardiovascular disease in patients with diabetes mellitus 2 type, and the current approaches to the medical therapy of these disorders. Obesity, metabolic syndrome, and diabetes mellitus 2 type are characterized by insulin resistance, which leads to excessive lipolysis of visceral adipose tissue. The consequence of this disorder is the excessive production of free fatty acids, which become the source for excessive synthesis of proatherogenic lipoproteins saturated with triglycerides. These lipid profile abnormalities are the main pathogenetic link between diabetes and increased risk of atherosclerosis. Chronically elevated levels of free fatty acids reduce insulin synthesis, glucose-stimulated insulin secretion, and β-cell sensitivity to glucose, resulting in a very high risk of developing diabetes mellitus 2 type. Numerous factors contribute to elevated plasma free fatty acid levels and subsequent impairment of metabolic health, such as unhealthy diet, obesity, low physical activity, obstructive sleep apnea, sleep deprivation, and smoking. Currently, lifestyle changes are the best tool for long-term normalization of the concentration of free fatty acids in the blood plasma. The results of modern research have proven that a healthy lifestyle and glycemic control, treatment with statins, ezetimibe, and hypoglycemic drugs improve the lipid profile, reduce insulin resistance and inflammation, which reduces the risk of cardiovascular diseases.
The importance of spiritual sanctification in the formation of human health
Authors:   Ukrainian Institute of Arts and Sciences, Kampen К.S. , Shevchuk A.V. ,   Ukrainian Institute of Arts and Sciences, Stinkovyy М ,   Ukrainian Institute of Arts and Sciences
Published: December 2022

The relevance of the research topic is due to the fact that in the era of information technologies, the dangers associated with the consumption of destructive information are often underestimated. Among the various vulnerable social groups in this study, the focus is on people with a Christian worldview. After all, the ratio of new information from the mass media and information related to the fundamental foundations of Christian ideology in the modern digital world is unequal. The main problem of the study is the specificity of the phenomenon of sanctification in the religious life of various denominations, including Christians. However, apart from the latter, the article clearly defines that in the modern world every country has its own traditional religion. That is why the stated problem is considered through the prism of a number of examples, namely the peculiarities of the understanding of sanctification in Judaism, Hinduism, Christianity, and Islam. This is due to the fact that each religion interprets this term differently. In the course of the research, this topic is considered objectively on the example of its interpretation in Protestantism, in particular, by the Seventh-day Adventist Church. In the actual understanding of this denomination, sanctification is understood as a phenomenon that, with the help of God’s grace, enables a person to harmonize his life with the principles of God’s holy Law. The article states that a person who does not strive for perfection, who does not reach for Christ, cannot be sanctified. After all, there is no point in the fact that a person was consecrated two days ago or a month ago, if he is now defiled. This approach is not traditional for many denominations, but its biblical origins analyzed in the study indicate that the phenomenon of sanctification can be understood in this way. According to the results of the scientists’ work, it is determined that the process of sanctification or purification is accomplished only with the help of Christ’s merit and only with a wide heart. In a person who is not purified, the Spirit of God cannot reside, and if He does not reside, then a person cannot be God’s channel for others. Thus, the problem of understanding the phenomenon of sanctification in view of its own debatable nature requires actual thorough research, in which parallels would be drawn between the way of life of modern Christians and its conformity to the creed.
Subjective cognitive decline, mild cognitive impairment, and dementia - syndromic approach: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology
Authors: Smid Jerusa , Studart-Neto Adalberto , César-Freitas Karolina Gouveia , Dourado Marcia Cristina Nascimento , Kochhann Renata , Barbosa Breno José Alencar Pires , Schilling Lucas Porcello , Balthazar Márcio Luiz Figueiredo , Frota Norberto Anízio Ferreira , Souza Leonardo Cruz de , Caramelli Paulo , Bertolucci Paulo Henrique Ferreira , Chaves Márcia Lorena Fagundes , Brucki Sonia Maria Dozzi , Nitrini Ricardo , Resende Elisa de Paula França , Vale Francisco Assis Carvalho
Published: December 2022

ABSTRACT This consensus, performed by the Brazilian Academy of Neurology (BAN) will approach practically how to evaluate patients with cognitive complaints and how to clinically and etiologically diagnose the three clinical syndromes associated with the different stages of cognitive decline: subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia. This BAN consensus discusses SCD diagnosis for the first time, updates MCI and dementia diagnoses, recommends the adequate cognitive tests and the relevant etiological work-up and care of patients with cognitive decline at different levels of care within the Brazilian Unified Health System. We also review the main assessment instruments used in Brazil and Latin America.
Declínio cognitivo subjetivo, comprometimento cognitivo leve e demência - diagnóstico sindrômico: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia
Authors: Smid Jerusa , Studart-Neto Adalberto , César-Freitas Karolina Gouveia , Dourado Marcia Cristina Nascimento , Kochhann Renata , Barbosa Breno José Alencar Pires , Schilling Lucas Porcello , Balthazar Márcio Luiz Figueiredo , Frota Norberto Anízio Ferreira , Souza Leonardo Cruz de , Caramelli Paulo , Bertolucci Paulo Henrique Ferreira , Chaves Márcia Lorena Fagundes , Brucki Sonia Maria Dozzi , Nitrini Ricardo , Resende Elisa de Paula França , Vale Francisco Assis Carvalho
Published: December 2022

RESUMO Este consenso realizado pela Academia Brasileira de Neurologia (ABN) abordará de maneira prática como avaliar pacientes com queixas cognitivas e como realizar o diagnóstico clínico e etiológico das três síndromes clínicas associadas aos estágios de declínio cognitivo: declínio cognitivo subjetivo (DCS), comprometimento cognitivo leve (CCL) e demência. O diagnóstico de DCS é discutido pela primeira vez em consenso da ABN e as atualizações para o diagnóstico de CCL e demência são abordadas, bem como a recomendação para o uso de testes cognitivos apropriados, investigação etiológica pertinente e cuidados aos pacientes com declínio cognitivo nos diferentes níveis de atenção do Sistema Único de Saúde. Foi realizada pesquisa dos principais instrumentos de avaliação utilizados em nosso meio e na América Latina.
Entre o Fazer de Conta e o Fazer Acreditar: as crianças e suas performances em instalações de jogo
Authors: Santos Nathalia Scheuermann dos , Carvalho Rodrigo Saballa de
Published: December 2022

RESUMO Entre o Fazer de Conta e o Fazer Acreditar: as crianças e suas performances em instalações de jogo – Fundamentado nos Estudos Sociais da Infância e nos Estudos da Performance, o artigo objetiva analisar os modos como crianças da Educação Infantil, com idades entre 3 e 5 anos, produzem performances durante brincadeiras em instalações de j ogo. Trata-se de uma pesquisa com crianças cuja metodologia é pautada na Abordagem do Mosaico e na proposição de instalações de jogo. Mediante as análises, foram definidas duas unidades: a) performances de fazer de conta; b) performances de fazer acreditar. Assim, foi possível fazer inferências a respeito do livre trânsito das crianças entre as performanc es de fazer de conta e fazer acreditar, por meio de suas modulações corporais, gestos e voz es.
Occupational repertoire in the national literature
Authors: Faustino Gabriela , Figueiredo Mirela de Oliveira
Published: December 2022

Abstract Introduction Concepts and constructs are fundamental to the theory and practice of any profession. In occupational therapy, although some concepts and constructs, such as the Occupational Repertoire, are present and/or on the rise in theoretical-methodological frameworks, they have not yet been extensively and systematically investigated, defined, and debated in the production of national knowledge. Objective The objective was to analyze the use of the Occupational Repertoire construct in the national occupational therapy literature. Method A scoping review was carried out in the main national journals in the area and the Google Scholar platform published between 1990 and 2020. The Boolean search strategy was used, in which the descriptors (occupational repertoire) and (occupation repertoire) were combined with the OR operator. Thus, in all journals, the following sentence was maintained: (occupational repertoire OR repertoire of occupations). The sample consisted of 20 publications. Results Of the 20 publications that made up the analyzed sample, 7 were published in the Brazilian Interinstitutional Journal of Occupational Therapy, 5 in the Cadernos Brasileiros de Terapia Ocupacional, 1 in the Revista de Terapia Ocupacional da USP and 7 in Google Scholar composing the gray literature (4 TCC, 1 paper, 1 abstract and 1 dissertation). The year of publication ranged from 2016 to 2020. Of the 20 publications that made up the sample, only the materials found in the gray literature had the occupational repertoire as their object of study, in the other publications, the occupational repertoire appears either in the introduction, in the results, in the discussion and/or final considerations as a complement/secondary element to the purpose of the publications. Conclusion Although the “occupational repertoire” construct corroborates the practice and theoretical discussion of occupational therapists in the international context, in Brazil, the literature on this construct is still incipient. Therefore, the importance of developing future research on the subject is highlighted, providing a dialogue between professionals, in addition to favoring the recognition and constitution of the profession.
Highly Selective and Sensitive Non-enzymatic Glucose Biosensor Based on Polypyrrole-Borophene Nanocomposite
Authors: BAYTEMİR Gülsen
Published: December 2022

In this study, a non-enzymatic glucose sensor composed of two-dimensional (2D) borophene-decorated polypyrrole (PPy) nanocomposites (NCs) was developed. The PPy-borophene NCs were prepared using a low-cost sonication method. The sensing performance of the PPy-borophene NCs was investigated by the cyclic voltammetry (CV) technique against various biomolecules such as glucose, maltose, lactose, fructose, and urea. According to the electrochemical results, it was observed that in the glucose concentration range of 1.5 to 24 mM within a voltammetric cycle of 1 min, the PPy-based sensor and PPy-borophene NCs-based sensor exhibited sensitivities of 11.88 μAmM−1 cm−2 and 213.42 μAmM−1 cm−2, respectively. The detection limits of the PPy-based and PPy-borophene NCs-based sensors were determined to be 0.5 µM and 0.04 µM, respectively. Furthermore, selectivity measurement results revealed that the proposed non-enzymatic biosensor has remarkably good sensitivity and high selectivity, indicating that common biomolecules (glucose, maltose, lactose, fructose, and urea) could be captured by the sensor. Consequently, it was proven that the proposed biosensor could be a potential device for diabetes diagnosis.
Critical Sensitivity in Digital Place-Craft to Unsettle Settler Sentiments of Place
Authors: Meeken Luke
Published: December 2022

This paper summarizes the methods and outcomes of my dissertation inquiry, which examined the potential that critical perspectives on digital placemaking practices may hold for art teaching with digital materials. Within this study, placemaking is the (often, but not always, intentional) shaping of the material qualities of a place. The study described in this paper examined how critical sensitivity to the material qualities of digital places (i.e. the actions and sensations places invite and inhibit) and critical sensitivity to the colonial ideologies digital places often materially enact and habituate, may inform the crafting of arts curricula as places, and inform youth artists’ crafting of digital places. Drawing on theories of digital materialism, curricula as digital places of learning, and critical and anticolonial framings of digital placemaking, the study summarized in this article suggests that habituating critical sensitivity to the material qualities of digital places is a viable approach to addressing ideologically-laden material qualities of the digital. The study also suggests that approaching curriculum development with critical sensitivity as an act of placemaking is a viable and valuable approach to navigating tension between structure and open-endedness in curricular design, and to attending to the ideologically-laden material qualities of curricular places.
COVID-19 at the workplace: What lessons are to be gained from early case law?
Authors: Mokofe W , van Eck S
Published: December 2022

The emergence of the COVID-19 pandemic and its consequences were overwhelming at South African workplaces. It had a significant impact on public and private life in South Africa and harsh rules were imposed that severely restricted social gatherings and other economic activities. Employers and employees grappled with issues like compulsory vaccinations, social distancing and the implementation of workplace policies at the workplace. The repercussions of the COVID-19 limitations are still being experienced after the lifting of the state of disaster. Among the issues are a troublesome economic downturn, significant job losses and a struggle to convince workers to return to workplaces. The Constitution, 1996 establishes a human rights-centred backdrop against which the picture of the pandemic is unfolding. Added to this, South Africa has a range of legislative instruments that regulate aspects like unfair dismissal and collective bargaining at workplaces. This placed South Africa in a position to regulate the COVID-19 pandemic in society at large, and workplaces in particular. A collection of the tribunal and court decisions regarding COVID-19 at the workplace have wound their way through the dispute resolution institutions. This contribution navigates relevant aspects of the Constitution as well as disaster management and labour legislation before reflecting on a selection of jurisprudence. The authors argue that there are important lessons to be gained from these early cases. Nonetheless, there are also unanswered questions of a constitutional nature that still need to be finalised. They also voice suggestions in the conclusion that may be of assistance to employers, employees, academics, and policymakers alike - that would also apply should future pandemics pester the South African society.
Molecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature review
Authors: Popov S. V. , Guseynov R. G. , Skryabin O. N. , Perepelitsa V. V. , Davydov A. V. , Barkhitdinov R. S. , Katunin A. S. , Mirzabekov M. M.
Published: December 2022

To compile this literature review, we studied at least 100 publications devoted to the genetic basis of clear cell, papillary, and chromophobic sporadic kidney cancer pathogenesis. Each of them considered the role of somatic gene and chromosomal mutations in the initiation, promotion, and tumor progression of sporadic renal cell carcinoma, emphasized the importance of determining the mutagenic profile of renal cell carcinoma for the future fate of patients.
Upper tract urothelial carcinoma: can the tumor be removed en bloc?
Authors: Martov A. G. , Ergakov D. V. , Andronov A. S.
Published: December 2022

Diagnosis and treatment of upper tract urothelial carcinoma (UTUC) remain important problems of clinical urology. UTUC en bloc i.e. in one-piece removal during organ-sparing surgery is still hardly possible. The most typical endourological operations are either electrosurgery, holmium or thulium YAG laser tumor vaporization.

We present a clinical case of ureteroscopic en bloc UTUC removal using a new super pulse thulium fiber laser (SPTFL, FiberLase U3). Recent innovations and trends in this field are also discussed. The technical steps of en bloc ureteroscopic tumor removal allowing for diagnosis verification, identification of pT stage and surgical margin are described. The further innovations in laser UTUC removal include modulation of laser pulse length and development of the correlation between preoperative tumor characteristics and possibility of en bloc removal.
Human interferon status. Standardization of the tests and establishing reference values
Authors: Lobov A. V. , Pogodina E. A. , Ivanova P. I. , Ugarova N. V. , Sorokina E. V. , Shubina I. Zh.
Published: December 2022

Background. Interferons are the most important component of nonspecific (congenital) resistance of the body, the history of their discovery dates back to 1957 and the study is still ongoing. Evaluation of an individual interferon status (IS) with the estimation of the sensitivity of leukocytes to immune reactive drugs has a practical aspect. IS is a set of parameters indicating the state of nonspecific resistance.Aim. To study the problems of standardizing the IS tests with the search for possible ways of standardizing the method and calculate reference values based on a large amount of data.Materials and methods. A retrospective statistical processing was performed using the database of the IS tests performed in the clinical diagnostic department of the laboratory center of Exacte Labs LLC from September 2020 to August 2022. Enzyme immunoassay kits based on commercial reagents were used. The paper describes the methodology for studying IS with an emphasis on the least standardized procedures.Results. Reference values were calculated using three indirect methods. The analysis of the results obtained made it possible to identify age groups for which it is advisable to establish reference values. The study results showed the inconsistency of the obtained reference values as compared with the previous ones, which indicates the need for their correction.Conclusion. The considered problems of performing and standardizing the method for IS analysis are of practical importance for establishing a standard methodology and an in vitro method. The reference values have been updated to avoid errors in the interpretation of the results and to increase the clinical significance of the study.
Cytotoxic and antitumor properties of methionine γ-lyase conjugate in combination with S-alk(en)yl–L-cysteine sulfoxides
Authors: Abo Qoura L. , Morozova E. A. , Koval V. S. , Kulikova V. V. , Spirina T. S. , Demidova E. A. , Demidkina T. V. , Pokrovsky V. S.
Published: December 2022

Background. Enzyme prodrug therapy is a promising strategy to treat solid malignancies. The utilization of two-component systems, including an enzyme and a non-toxic prodrug, to generate cytotoxic compounds directly at the surface of the tumor cell can be successful strategy in reducing the overall toxic load on the body.

Aim. To determine antitumor activity of the pharmacological pair C115H methionine γ-lyase (C115H MGL) conjugated with daidzein (C115H MGL-Dz) and of S-alk(en)yl-L-cysteine sulfoxides against various types of solid tumors in vitro and in vivo.

Materials. MTT-test was used to determine the cytotoxicity of C115H MGL-Dz in the presence of S-alk(en)yl-L-cysteine sulfoxides in vitro against Sw620 (colon cancer), Panc1 (pancreatic cancer), and 22Rv1 (prostate cancer). Apopto- sis induction and cell cycle alteration in 22Rv1, Sw620, and SKBR3 cell lines were studied using the Muse® Caspase-3/7 and Muse® Cell Cycle Assay kits. In vivo anticancer activity was studied on Sw620, Panc1, and 22Rv1 subcutaneous xenografts in Balb/c nude mice.

Results. The C115H MGL-Dz had the maximum cytotoxic activity in the presence of S-propyl-L-cysteine sulfoxide (propiin) with IC50 values: 3.88 and 5.4 for Panc1 and 22Rv1, respectively. Dipropyl thiosulfinate formed by the β-eli-mination of propiin catalyzed by C115H MGL-Dz, induces apoptosis through both the activation of caspases and alternative pathways, and also it inhibits cell division, contributing to a decrease in the concentration of cells in the G2/M phase. The anticancer efficacy of the pharmacological pair C115H-Dz/propiin in vivo indicated a significant decrease in Panc1 tumor volume (tumor growth inhibition (TGI) 67.5 %, p = 0.004), Sw620 (TGI 22.07 %, p = 0.12) and 22Rv1 (TGI 70 %, p = 0.043).

Conclusion. Pharmacological pair C115H MGL-Dz/propiin was capable of suppressing tumor development in malignant solid tumors and might be considered as a potential anticancer approach in cancer prodrug therapy.