bluuebunny/crossref_metadata_2025 huggingface dataset:
The Abuse of Neurodegeneration Disease and How CRISPR-Cas9 Could Help with The Disease
Authors: Xia Tian
Published: April 2023

Neurodegenerative disease has been discovered for more than a hundred years. This disease gradually damages the brain neuron activity and leads to death. There is no way to entirely heal the disease currently but scientists are still looking for some methods to slow it down and heal from it. More hope appears after the third generation of gene editing technology-CRISPR-Cas9- is discovered. This is a natural gene editing technology by CRISPR gene and Cas9 protein in the body with more precision and less cost than the previous two generations. CRISPR-Cas9 technology is based on the natural body system that detects and prevents virus RNA, and targets a precise sequence of genes to accomplish gene editing. Researchers believe that the damage of neurons by the disease could be slowed down or even stopped by knocking out the neurodegeneration related gene and knocking in desired healthy genes. Huntington disease, one of the most popular diseases in neurodegenerative disease, has been discovered relatively more. This research review focuses on the history of CRISPR-Cas9 gene editing technology and how it helps with neurodegenerative disease, especially with Huntington Disease.
Principles, Processes and Modalities of Interaction Between Proto-Oncoprotein PIM-1 Kinase and Cell Division Cyclin CDC25A
Authors: Li Qianyi , Jin Haoran , Zhao Shifeng
Published: April 2023

All malignant tumors with aberrant cell differentiation and proliferation, unchecked growth, invasion, and metastasis are referred to as cancer. Its occurrence is a multi-step, complex process with many contributing components. Proto oncoprotein and The PIM kinase family is crucial to this procedure., and proto oncoprotein PIM-1 kinase is an important member of PIM family. The expression of proto oncoprotein PIM-1 is positively correlated with the status of lymphatic metastasis, and its overexpression could promote cell cycle and inhibit apoptosis. Cell division cycle 25 (CDC25) is a bispecific phosphatase from Schizosaccharomyces cerevisiae in 1986. CDC25 can activate CDK by catalyzing the dephosphorylation of inhibitory phosphorylation sites in the cell cycle dependent protein kinases (CDK) molecule, and regulate the response to DNA damage, thus promoting cell cycle operation. The interaction between the proto oncoprotein CDC25A in the above process is one of the keys to the current mechanism research with PIM-1 kinase. In this paper, PIM-1 and CDC25 are first introduced, respectively. Then, the interaction between PIM-1 and different substrates with a focus on CDC25A is presented. Finally, their role in tumor initiation and the application of CDC25A as a therapeutic target are highlighted. Therefore, this paper will discuss the interaction between CDC25A and PIM family.
Advantages And Disadvantages of Combining Chinese and Western Medicine in The Treatment of Chronic Atrophic Gastritis
Authors: Wu Jiexiong
Published: April 2023

Chronic atrophic gastritis is also known as atrophic gastritis. It is a chronic digestive disease caused by atrophy and a reduction in the number of epithelium and glands of the gastric mucosa. With social and economic development, and the dramatic increase in social competitive pressure, people's living habits and dietary habits have changed, triggering the incidence of gastrointestinal diseases to increase year by year. Among them, the incidence of atrophic gastritis shows an increasing trend year by year. In this paper, the risk factors that may lead to atrophic gastritis and its pathogenic mechanisms are summarized and analyzed through literature analysis. The relevant treatment options such as Western medicine, Chinese medicine, and combined Western and Chinese medicine were compiled and their efficacy was compared. Numerous studies have shown that people with poor lifestyles and dietary habits, as well as those who are chronically in a bad mood, are more likely to develop atrophic gastritis. The available treatment options are TCM, Western medicine, and a combination of Western and Chinese medicine, but there are limitations to choosing TCM or Western medicine alone. The future direction of atrophic gastritis prevention and treatment is to combine the advantages of Chinese medicine and Western medicine in the treatment process.
Inflammation In Relation to Alzheimer’s Disease and Potential Treatments
Authors: Zhou Zining
Published: April 2023

Alzheimer's disease (AD) affected millions of people. As it is widely associated with its two hallmarks, Aβ and NFT, its relationship with inflammation is less studied, but gaining more attention in recent years as more experiments and researches provide sufficient results to prove the close relationship between the two. By collecting and covering a variety of experiments and reports conducted over the years, this review projects to include an in-depth analysis of pathogenesis of Alzheimer’s disease, discussing its connection with inflammation in its formation and development, while seeking for treatments targeting inflammation as a potential solution to prevent, reduce and reverse Alzheimer’s disease in the future. From researches done up to date, there are numerous failures regarding anti-inflammatory treatment of Alzheimer’s, but some early studies show positive results of new drugs targeting different inflammatory mechanisms which are able to attenuate the disease. More of relevant studies can be done in the future as a potential solution to AD.
The Science of Amniotic Fluid Embolism
Authors: Xu Yifei
Published: April 2023

With many countries around the world facing aging populations and declining birth rates, governments are encouraging women to have children. However, few countries are really concerned about the effects of pregnancy on women, and society is hiding the risks and symptoms of pregnancy and postpartum complications as if to get more women to have children by hiding these facts. What I believe is that only when women truly understand the process and risk factors of pregnancy can they be prepared to give birth with confidence. People are always afraid of the unknown. This article systematically analyzes the disease with the highest mortality rate during pregnancy, amniotic fluid embolism (AFE). Hopefully, this article will make more people aware of this rare but highly fatal disease. This article introduces various aspects of AFE, the most central part of which should be the analysis of the causes of AFE and the current treatment methods. The author hopes that after reading this article, the reader will be able to eliminate as many questions as possible about AFE.
Treatment of Various Stages of Periodontitis and Prevention of Periodontitis
Authors: Liu Qianyu
Published: April 2023

Periodontitis is an infectious disease caused by bacteria destroying periodontal supporting tissues. As the number of patients with periodontitis is increasing, more attention is being paid to the prevention and treatment of periodontitis. The incidence of periodontitis in China is about 70%. Currently, periodontitis has been considered one of the three major diseases that endanger human oral health. Both diabetic patients and hypertensive patients have a higher risk of periodontitis disease than healthy individuals. Advanced stages of periodontitis are often accompanied by tooth loss, and tooth loss can lead to decreased chewing function, which can lead to diseases such as indigestion and gastric ulcers. Besides, A growing body of research links periodontitis to Alzheimer's disease. Periodontitis is closely related to other systemic diseases. Therefore, the prevention and treatment of periodontitis is important. The paper summarizes the treatment measures for periodontitis in different periods in the new international classification of periodontal diseases in 2018 by analyzing the relevant literature and also introduce the measures related to the prevention of periodontitis.
New Treatments for Acne in The Context of Antibiotic Resistance
Authors: Hara Akemi
Published: April 2023

Acne has long been recognized as a widespread skin condition, and its prevalence is currently increasing. One of the top 10 epidemics in the world right now, it has a serious psychological toll on its victims. Four interconnected processes, including inflammation, increased sebum production, follicular infundibular hyperkeratosis, and Chlamydia acne growth, make up the disease's complicated pathophysiology. Antibiotics that target P. acnes have been a successful and popular way to treat acne for the past 40 years, even though the pathophysiology of acne is not entirely understood. The emergence of antibiotic resistance, however, is a persistent issue with a variety of negative consequences. Isotretinoin and antiandrogen therapy are frequent therapies for certain of them. This article summarizes the effectiveness and safety of oral antibiotics for acne treatment in recent years as well as some other recent treatment research, operating under the premise that the current domestic and international clinical trials of acne vulgaris are insufficient. The goal is to raise awareness of acne vulgaris.
Impacts And Preventions of COVID-19
Authors: Yan Luzhu
Published: April 2023

The goals of public health are to protect and advance the well-being of both individuals and the communities in which they reside. However, the coronavirus disease 19 (COVID-19), a recent emerging plague, has had a catastrophic effect on sanitation. COVID-19 has infected more than 650,000,000 individuals and caused over 6,000,000 fatalities worldwide. In this study, how COVID-19 affects human beings, societies, and countries is discussed. Additionally, COVID-19 is investigated in several aspects such as mechanisms, contagiousness, persistency, mortality, and sequelae. Furthermore, the paper provides suggestions for preventing COVID-19. Considering the disease's analysis, its impairment of it is unmeasurable. Despite the fact that researchers have created a viable COVID-19 vaccine, there is no guarantee that people will not be infected due to the properties of the disease. However, the probability of being too sick or dying is reduced because of the vaccine. In this paper, people can gain a comprehensive view of the influence, infection mechanism, and nature of COVID-19. In addition, another purpose is to help people protect themselves from this disease.
Application Of CRISPR-Cas in Pathogen Detection
Authors: Wu Yunfei
Published: April 2023

Infectious diseases have had a significant influence on the market economy and human civilization in recent years. Traditional nucleic acid tests typically include a lot of procedures, are complicated, take a long time to complete, and have significant space, staff, and equipment needs. More and more study is being done in this area as a result of the identification of clustered regularly interspaced short palindromic repeats and related(CRISPR-Cas) proteins in prokaryotes. The CRISPR-Cas system has been extensively used to detect viruses that cause infectious diseases due of its high specificity and sensibility. The history of the CRISPR-Cas system, including its revised categorization, is discussed in this paper. Besides, a summary of the use of various CRISPR-Cas system types in pathogen detection is also provided in the paper, along with an introduction to the CRISPR-Cas system’s basic principles employing CRISPR-Cas9 as an example. As a biosciences frontier hot spot, research on CRISPR-Cas systems is developing quickly and technology based on the CRISPR-Cas system for detecting pathogens is extremely useful in clinical diagnosis and biological research.
The Systematic Research of The Comparison of Moderna Covid-19 Vaccine and Pfizer Covid-19 Vaccine
Authors: Wang Qiming
Published: April 2023

The outbreak of the one-of-a-kind coronavirus in March of the year 2020 was designated as a pandemic by the World Health Organization. This article will cover the mechanism of action, mode of administration, adverse effects, and effectiveness of the Pfizer and Moderna created mRNA COVID-19 vaccine, which is licensed for use in the United States, as well as current times. In addition, the evolution of the illness is going to be covered in this article. Pfizer and Moderna, respectively, have created mRNA vaccines that encode the SARS-CoV-2 spike-in protein in order to combat the SARS-CoV-2 outbreak. Since the United States government issued an emergency permission to administer the vaccine there, both those who took part in clinical trials and members of the general public have shown that the vaccine is safe to use. Pfizer and Moderna's SARS-CoV-2 vaccines have been demonstrated to be 95.0% effective in avoiding infections that are regarded as being mild or symptomatic. Because these vaccinations are now the subject of ongoing clinical research, it is essential to have access to medical literature that has been brought up to date. This is especially significant when they are researched in a variety of age groups as well as when new strains of SARS-CoV-2 coronavirus develop. In addition to this, the article presents a succinct review of the future of mRNA vaccines, and it makes the statement that mRNA vaccines will play a significant position in the creation of future human vaccines.
Systematic Review of Respiratory Syncytial Virus Vaccine Efficacy
Authors: Li Jiajin
Published: April 2023

As the development of the vaccine against respiratory syncytial virus (VRS) has been rapid recently with the innovation of all sorts of gene engineering tools, it is necessary to analyse the efficacy of all kinds of relevant vaccines comprehensively to accelerate the massive usage of them. In order to achieve it, a systematic analysis was needed along with selecting all kinds of articles published from 2018 to 2020 in various databases (Pubmed, EMBASE and Cochrane library) to get the target data. The procedure was carried out by two independent examiners and supervised by another examiner. Five articles were picked, for a total of 12,719 observed people aged less than 3 months to about 26. The results of the RBM meta-analysis were that the estimated vaccine efficacy was 62% (95% CI: 36% to 78%) with high heterogeneity (I2 = 87%). The subgroup analysis showed that multiple factors contributed to the heterogeneity of the research and indicated that it is better to focus on modifying the vaccine on both infants and adults to prevent the spread of RSV. All in all, compared with other commercial vaccines, the efficacy of the RSV vaccine still needs to be improved and more trials on the safety and immunogenicity have to be operated in the future.
Comparisons Of Mrna Vaccine from Different Manufactures
Authors: Wang Yinan , Zou Xinyu
Published: April 2023

The severe acute respiratory syndrome coronavirus 2, which is responsible for the COVID-19 pandemic, causes severe respiratory illness. The condition was initially discovered in December 2019 and spread all over to the world, causing 6724248 deaths by January 25th 2023 worldwide. Through the course of three years from 2019 to 2022, the virus has developed multiple variants from Alpha, Beta, Gamma, Delta and Omicrons. In response to a virus with such a rapidly mutating virus, the development of mRNA vaccines has been prioritized. The easiness of producing mRNA vaccine allowing less time can be spent on the development phase of a vaccine. Thus, mRNA vaccines can also be updated frequently to keep up the mutations in the virus. Three mRNA vaccines are described in this article (two of them are currently available and one is still developing) in terms of target protein, effectiveness, adverse effects and price and compare them to give recommendations for different cohorts.
The Therapeutic Potential of CRISPR-Cas9 in Drug Resistance During Cancer Treatment
Authors: Zhang Jingru
Published: April 2023

With population aging on the rise, cancer's burden as the main cause of death has dramatically increased globally Although multiple treatment methods are available, the death rate is high. Drug resistance is still the main factor contributing to cancer deaths and recurrence at this time. The implementation of the CRISPR-Cas 9 gene editing approach plays a promising role in reducing drug resistance during cancer therapy because the main mechanism of drug resistance is genetic composition shifting. CRISPR-Cas9 has already served as a potent approach in several industries, particularly in those of agriculture and health. Nevertheless, given the limitations of CRISPR-Cas9 application, more study is required to lessen the unfavorable side effects. The mechanisms of the CRISPR-Cas9 technique and the mechanisms of drug resistance in chemotherapy have been reviewed in this article, along with the history of CRISPR-development, Cas9's current application fields, and potential application opportunities and CRISPR-limitations Cas9's in overcoming drug resistance.
Cancer Research Using Crispr/Cas9 Gene Editing Technology
Authors: Li Yunhe , Zhang Boyang
Published: April 2023

Gene editing technology has completely transformed the life sciences and medical treatment, because it makes precise and stable genetic alterations to genomic sequences possible. Among gene editing technologies, CRISPR system is now the most employed one. CRISPR technology is currently often used in the medical field including cancer study as well as genome editing in a number of animals. Besides, the CRISPR system has been widely used in agriculture, industry and other fields, such as crop breeding, industrial microbial design, viral nucleic acid detection, etc. In the framework of people’s knowledge of cancer research and genome editing technology, this paper focuses on the adhibition of CRISPR/Cas9 in cancer modeling, high throughput genetic analysis of tumor cell metastasis-related genes, as well as cancer treatment. It indicates that CRISPR/Cas9 techniques can be a promising tool in cancer diagnostics and therapeutics. Although CRISPR / Cas9 technology has limitations such as being off-target, this technology undoubtedly has great potential in cancer or other diseases in the future.
Off-Target Effects Of CRISPR/Cas9 and Their Solutions
Authors: Chao Rui , Fei Jiaqi
Published: April 2023

In the continuous exploration, the superiority of CRISPR/Cas9 system has been discovered. Its ability to edit target genes with high specific and low cost has greatly increased the convenience of constructing biological models, accelerated the screening of targets and effectively improve the gene editing technology. However, when CRISPR/Cas9 system is used in the studies, these studies are frequently constrained by the off-target effects, which may result in mutations in the experimental products and erroneous experimental data. Therefore, this paper mainly introduces CRISPR/Cas9 and the principle of its off-target, and discusses the effects of off-target from PAM sequence, sgRNA and other aspects. To more thoroughly study the off-target effects' mechanism, this paper also lists three kinds of detection technologies of off-target effects. Finally, three solutions including designing sgRNA, changing the abundance of Cas9/sgRNA and improving Cas9 protein were analyzed and discussed from the effects of off-target, which provided ideas for reducing the off-target effects and improving genome editing technology.
Research Progress in The Application of CRISPR Gene Editing Technology in Virus Detection and Treatment
Authors: Pang Jiahui
Published: April 2023

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) gene editing (GE) technique is the latest generation of GE technology, which can carry out targeted and precise modification of the genome. In this article, a comparison of the Zinc-Finger Nucleases (ZFNs) , CRISPR/Cas and Transcription Activator-Like Effector Nucleases (TALENs) is presented, which indicates that CRISPR/Cas has significant advantages. For example, synthesis and screening are simpler and faster, and multiple genes can be edited simultaneously. To keep abreast of the times, current progress in the application of CRISPR in virus detection as well as treatment will be introduced in this paper. Firstly, CRISPR and its characteristics will be briefly introduced. Then the current application of CRISPR about detecting and treating viruses will be reviewed. Finally, the paper summarizes the shortcomings of CRISPR and looks forward to its future development.This article attempts to give readers a brief introduction to the emerging technology based on CRISPR and highlights its potential applications in virus detection and treatment.
Advantages And Disadvantages of Different COVID-19 Vaccines
Authors: Wang Anqi
Published: April 2023

After the outbreak of the epidemic, countries around the world have begun intensive research and development of vaccines. Theoretically, all existing vaccine types and technologies can be applied to COVID-19 vaccine research. More than 100 COVID-19 vaccine projects registered on the official website of WHO include these three generations of different types of vaccines. At present, 16 vaccines have entered clinical trials, five of which are from China, including two inactivated vaccines under China Biotechnology Co., Ltd. (hereinafter referred to as "China Biotechnology"). Most of these vaccines are still in phase I. This article will introduce inactivated vaccine, Ad5-nCoV Adenovirus vector COVID-19 vaccine, RBD CHO vaccine and nucleic acid vaccine in detail. The different vaccines have different advantages due to the different ways of working. At the moment when the COVID-19 vaccine has been launched, personal protection and cutting off the transmission route of COVID-19 are still the most important ways to protect oneself and prevent the spread of the epidemic.
Treg Cell And PD-1 In Cancer Immunotherapy
Authors: Feng Haomin , Wang Jiayue , Yu Ruibo
Published: April 2023

Cancer results from the abnormal life activity of some cells in the human body. These abnormal life activities are mainly reflected in uncontrolled division and proliferation and can infiltrate and destroy normal human tissues. In actuality, more than a million people die from cancer annually, and it ranks first among the main causes of death globally. Common cancers include skin cancer, lung cancer, gastric cancer, pancreatic cancer, etc. In the modern era, immunotherapy is the mainstay of treatment for some relatively common cancers, such as breast and prostate cancer. There are many ways to treat cancer in the world. In this article, the author only compares two possible ways to treat cancer: Treg cell method and PD-1 therapy. This paper tried to clarify the advantages and disadvantages of these two immunotherapies in cancer treatment by studying and comparing the two immunotherapies for cancer treatment, to help researchers find better ways to treat cancer with immunotherapy.
Application Of Quantum Dot Fluorescent Dyeing Technology in Tumor Detection
Authors: Xiang Yiting , Fang Weifan , Huang Longren , Jia Rongwei , Zhang Zhengguo
Published: April 2023

As a high-incidence disease, the tumor poses a huge threat to human health today. The timely and efficient detection of tumors is of great significance to improving the cure rate and improving people's health. Quantum dots have advantages of high fluorescence intensity, good stability and good biocompatibility, providing a new research approach for the detection of tumor markers. This paper reviews the application of quantum dots fluorescent dyeing technology in biosensing, imaging, tumor detection and treatment, which provides a reference for the development of tumor detection technology.
Additive Manufacturing and Topology Optimization in Orthopedic Implants
Authors: Mu Zhenping , Liu Tongtong
Published: April 2023

Compared with traditional manufacturing methods, additive manufacturing (AM) has many advantages in the realm of orthopedic implants, including facilitating the creation of anatomically matched devices and surgical instruments by using the patient’s medical image data, manufacturing complex geometric structures, and creating engineered porous structures and internal support structures. The combination of AM with CT or MRI imaging technology has showed great benefits when the patient’s bone geometry is not within the specifications of a standard-size implant, or only when a customized solution can deliver better clinical results for the patient. This paper summarizes the AM technology and its application in orthopedic implants, which will be of broad interest to medical researchers.
Exploring the mechanism of acupuncture for Parkinson's disease based on network pharmacology techniques
Authors: Cui Xinyu , Wang Taiyi
Published: April 2023

Objective: To explore the potential mechanism of action of acupuncture for Parkinson's disease using network pharmacology. Methods: Firstly, Parkinson's disease-related targets were collected from the DisGeNET disease database, followed by the GEO database to obtain the possible targets of acupuncture for Parkinson's disease, and the targets of the active substance-dopamine produced after acupuncture were predicted in the SuperPred database. All target IDs were converted into corresponding gene IDs in the UniProt database. Finally, the disease targets of Parkinson's disease were intersected with the potential targets of acupuncture treatment to obtain the key targets of acupuncture for Parkinson's disease, and these key targets were analyzed for GO and KEGG pathway enrichment. Results: A total of 2079 targets for Parkinson's disease were obtained, 3193 targets for acupuncture treatment of Parkinson's disease, and 24 key targets. GO and KEGG enrichment analysis was performed on the key targets, and the most significant GO entries and key pathways were obtained for targets in cellular components, molecular functions and biological processes. Conclusion: Acupuncture may treat Parkinson's disease via activating cAMP signaling pathway, IL−17 signaling pathway and dopaminergic synapse.
Preparation of pH-Sensitive Polymeric Nanoparticles for the Targeted Delivery of Doxorubicin with High Drug Capacity
Authors: Li Yunmo
Published: April 2023

In this study, pH-responsive prodrug nanoparticles PEG-Schiff-doxorubicin (PEG-Schiff-DOX) were designed and synthesised using chemical conjugation method and can self-assembly into spherical micelles in aqueous solution. These nanoparticles show good storage stability which can be stored over one week under normal condition. The acid-liable Schiff linker is stable under neutral pH and cleave under acidic environment, allowing the prodrug micelles to withhold DOX anticancer drug when being delivered in human circulation and disassemble to release drug once enter tumor cell tissue or taken into intracellular endosomal and lysosomal compartments. In addition to the enhanced permeation and retention (EPR) effect possessed by nanoparticle [1], the nanoparticle prodrug PEG-Schiff-DOX possess an advanced drug release behaviour, resulting in higher intracellular drug concentration in cancer cells and prolonged time of action. The superior anticancer effect of these nanoparticles against Hela cells is also investigated with CCK-8 assays, demonstrating the great potential for clinical application of PEG-Schiff-DOX in cancer treatment.
Kinetic fitting of methane adsorption rate and its influencing factors
Authors: Yu Zhen
Published: April 2023

In order to reveal the mechanism of the influence of coal matrix pores on methane adsorption rate, based on the high-pressure methane isothermal adsorption experiment of coal samples with different pore structures, the desorption law of methane in coal and its internal relationship with pore structure were studied by analyzing the change of methane adsorption amount at a single pressure point over time. Bangham kinetic model was used to fit the adsorption process, and constants representing the adsorption rate were obtained. The following understandings were obtained: (1) With the decrease of particle size, the adsorption equilibrium time is shorter, small particle size samples often have more complex pore structure, which makes the adsorption reaction between gas-solid interface more active, but the particle size itself cannot increase or reduce the size of the accumulated adsorption amount at the equilibrium, it only changes the length of time required to reach the adsorption equilibrium. (2) With the increase of the mesh number, the adsorption rate also increases, but the higher the coal rank, the greater the adsorption rate growth rate.
Analysis and Research on the Current Situation of Energy Use in Rural Areas of Tibet and Sichuan
Authors: Wan Li , Liu Chengpeng , LUOSONGZEREN  , Liu Yue , Wang Wei , SANGYONGLAMU  , Zhang Xiaoyu
Published: April 2023

This article has conducted relevant surveys on the current situation of energy use in rural areas of Linzhi City, Tibet, and Heishui County, Sichuan. The survey results show that in terms of energy sources, fuelwood accounts for the largest proportion in rural areas of Linzhi City, Tibet, accounting for 72.2% to 74.7% of energy use. Moreover, the proportion of renewable energy in rural areas is 4.5 times that of pastoral areas, and 18 times that of resource rich areas. In rural areas of Heishui County, Sichuan Province, dried cow and sheep dung is the main energy source, accounting for 79.8% of the total energy consumption. The utilization rate of renewable energy in daily life is relatively low, only 0.3%.
Research on uplift mechanism of screw pile
Authors: Zhang Yunchen , Shi Chao , Xu Chengjun , Qin Rongbing , Ye Hanxin
Published: April 2023

This paper uses numerical simulation software to study the bearing characteristics of screw pile with pitch after installation. The selected soil is single layer sandy soil, and the blade is buried in deep burial mode. Based on the numerical simulation results, the vertical bearing characteristics of single spiral pile and ordinary bladeless pile are compared, and the excellent compression and pull-out characteristics of spiral pile are revealed. Then, the influences of different pitch sizes, blade diameters, tilt angles, blade numbers and blade spacing on spiral single pile were compared and analyzed. The results show that single screw pile has higher bearing capacity and bearing efficiency. The vertical bearing capacity of single inclined screw pile has no obvious improvement compared with that of straight pile.
Sedimentary microfacies characteristics within the high-resolution sequence framework of the Fuyu oil layer in the New North region
Authors: Fu Xingyu
Published: April 2023

The Xinbei Oilfield has gone through decades of exploration and development, and lithological oil and gas reservoirs with stronger concealment are currently the focus of research. It is urgent to implement the sedimentary microfacies and sand body distribution characteristics of the Fuyu oil layer in the Xinbei area, providing a new theoretical basis for predicting the "sweet spot" of facies control in the area. Using core, logging, and logging data from the study area, a high-resolution sequence stratigraphic framework of the Fuyu oil layer was established. The distribution characteristics of sedimentary microfacies within the sequence framework were analyzed. The study showed that the Fuyu oil layer in the study area was divided into one long-term base level cycle of rising half cycle, four medium-term base level cycles, and 13 short-term base level cycles; In the area, river controlled shallow water delta plains and front sediments are developed, and a total of 10 types of sedimentary microfacies have been identified. Among them, the (underwater) distributary channel sand body, as the dominant reservoir sand body, extends along the southwest to northeast direction. As the A/S value increases, four stacking styles are developed vertically, including vertical shear stacking, staggered shear stacking, horizontal shear stacking, and isolated distribution. In the horizontal, the locally developed wide channel sand body composite zone gradually transitions into a single channel.
Preparation of nano emulsion with high salt resistance
Authors: Lai Hao , Shi Wei , Lai Nanjun
Published: April 2023

In this paper, the high salt shale reservoir as the research object, through the combination of microemulsion dilution method and pseudo-ternary phase diagram to screen the salt resistance of good nano emulsion. In the system, D-limonene was used as the oil phase, and the surfactant CAB-35 and AOS were selected by pseudo-ternary phase diagram method as the surfactant in the ratio of 1:1, and then mixed with n-butanol in the ratio of 1:1 to obtain the best microemulsion effect. The nano emulsion system was prepared by diluting the microemulsion. By testing the interfacial tension, the optimum preparation conditions of nano emulsion were screened. The results showed that the nano emulsion prepared by dilution under the condition of 5:5 oil/water ratio of microemulsion system had the best ability to reduce the interfacial tension between oil and water.
Study on the architecture of tidal controlled estuarine complex sand bodies in M oilfield, Oriente Basin, Ecuador: A case study of LU Formation
Authors: Yang Guoqing
Published: April 2023

The M oilfield in Oriente Basin, Ecuador has the characteristics of large well spacing and few Wells, and it is difficult to determine the lateral distribution range of sand bodies between Wells. Based on the well logging and seismic data, this paper discusses the sand body configuration characteristics of the Upper Cretaceous tidal controlled estuary reservoir in Oriente Basin in detail. The vertical and lateral contact relationships of reservoir are studied by single well identification, well point phasing, well profile analysis, and fine boundary characterization of seismic simulation, etc. Combined with microfacies types, the vertical overlapping relationships of 3 kinds of 7 types of sand bodies and lateral distribution relationships of 3 kinds of 5 types of sand bodies are summarized. It provides ideas for the study of this kind of sedimentary environment configuration and lays a foundation for the next study of remaining oil distribution law.
Shale gas transport model considering gas adsorption and desorption
Authors: Zhang Xu
Published: April 2023

The gas migration mechanism and apparent permeability in shale reservoirs are significantly different from those in conventional gas reservoirs, which is mainly caused by nanoscale phenomena and organic matter as gas storage and supply media. However, in shale reservoirs, gas flow behavior plays an important role in well performance, so it is necessary to develop a new apparent permeability model considering gas transport mechanism. Therefore, in order to study the change of matrix permeability under different pressures in the development process of shale adsorption layer, combined with previous studies, considering the seepage mechanism of stress sensitivity, real gas effect and adsorption, a new model of apparent permeability is created by combining multiple gas transmission mechanisms. The sensitivity analysis of the new model is carried out by changing the corresponding parameters, and the corresponding conclusions are drawn. In this work, the established model can accurately calculate the apparent permeability of viscous flow, Knudsen diffusion and desorption, which makes us have a more accurate understanding of the transmission mechanism of shale gas and contributes to the efficient and sustainable development of shale gas.
Inspiration and application value analysis of Chang 4+5 reservoir geological characteristics for exploration and development
Authors: Yue Wu , Zhao Yonggang
Published: April 2023

This paper takes the Chang 4+5 oil formation as the research object, and explores its implications and application value for exploration and development through the analysis and research of its geological characteristics. Firstly, the geological background of the Chang 4+5 oil formation is introduced, and its stratigraphic, structural, sedimentary and lithological characteristics are analyzed. Secondly, combined with practical cases, the influence of the geological characteristics of the Chang 4+5 oil formation on exploration and development is discussed, as well as how to use these characteristics to improve the efficiency and quality of exploration and development. Finally, the application value of the geological characteristics of the Chang 4+5 oil formation is summarized, and the future research direction and focus are pointed out.
Application of Nanoparticles to Enhanced Oil Recovery
Authors: Lv Wang , Wang Kai
Published: April 2023

Due to the disadvantages of traditional EOR methods, such as low sweep efficiency, formation damage and poor environmental protection, nanotechnology has attracted great attention in improving oil recovery due to its cost-effectiveness and environmental protection. Common types of nanoparticles that can play an effective role in enhancing oil recovery include oxides of aluminum, zinc, magnesium, iron, zirconium, nickel, tin and silicon. At home and abroad in this paper, the different types of nanomaterials research progress on the reservoir and production technology are introduced in detail, involving nanoparticles in effect on the viscosity of heavy oil and hydraulic fracturing technology, heat recovery technology, low salinity water injection technology and steam foam flooding technology and changing wettability, to reduce the oil/water interfacial tension and so on the basis of theoretical research and application situation. Scholars at home and abroad have carried out a lot of experiments and numerical simulations on the role of nanoparticles in enhancing oil recovery, as well as the required concentration and action conditions, and elaborated on the mechanism of nanoparticle enhanced oil recovery. In this paper, the latest research progress in this field at home and abroad is reviewed, and the key problems and development direction in the application of nanotechnology are pointed out.
Research and implementation of encoding and decoding technology of Layered Water Injection Based on Wave Code
Authors: Zhao Jian , Li Yang
Published: April 2023

The layered water injection technology based on wave code communication is one of the fourth-generation separated layer water injection technology, widely used in low permeability oil field with pressure operation injection Wells, has the advantages of simple operation and low cost. However, there is a problem of low communication efficiency. In order to solve the problem of low communication efficiency, this paper compares the advantages and disadvantages of amplitude time modulation encoding and pulse position interval encoding, and proposes a method based on pulse position interval encoding and decoding. Finally, the pressure wave communication experiment is carried out. The results show that when the pulse width is set to 5s, the communication time of a set of opening instructions is only 3 minutes, which greatly improves the communication efficiency of the wave coding process. The research on encoding and decoding can provide technical and theoretical support for improving the communication efficiency of layered water injection based on wave code.
Study on Physical Properties and Energy Evolution of Natural Gypsum Rock under Freeze-thaw Cycles
Authors: Wang Shengzhu , Qin Jianyun , Zheng Keke , Yang Fajun , Zhang Yang , Wei Sijiang , Ren Dahua
Published: April 2023

The physical and mechanical properties, microstructure deterioration characteristics and damage mechanism of natural gypsum rock under freeze-thaw cycles were studied by using a self-developed programmed freeze-thaw experimental device, results showed: Compared with that before freeze-thaw, with the increase of freeze-thaw cycles, the surface dissolution of gypsum rock samples becomes more obvious, the longitudinal wave velocity decreases linearly, the uniaxial compressive strength and elastic modulus decrease exponentially, the compaction stage of stress-strain curve is significantly prolonged, and the plasticity of post-peak failure process is enhanced. With the increase of axial strain, the total input energy curve rises at a faster rate, and the elastic energy curve also rises, but the rising rate slows down significantly after the freeze-thaw cycle, and the dissipation energy curve gradually evolves from a smooth rise to an ' S ' type. The research results have reference significance for the construction scheme design and frost damage prevention of gypsum surrounding rock tunnels in cold regions.
Research on oil and gas production prediction process based on machine learning
Authors: Liu Zhenzhi , Li Sanshan , Li Lu
Published: April 2023

In recent years, the development trend of artificial intelligence is getting better and better. It has been widely used not only in the fields of big data analysis, automobile automatic driving, intelligent robot and face recognition, but also in various fields of oil and gas industry. Oil and gas production prediction is an important part of reservoir engineering, which is very important for the future production and development of strata, and can give developers some development suggestions. At present, the methods used in oil and gas production prediction are mainly traditional means such as numerical simulation and history matching. With the application of artificial intelligence in various fields of oil and gas industry, the use of machine learning models for oil and gas production prediction has become the direction of development and research. This paper summarizes the basic process and main technical means of applying machine learning model to predict oil and gas production by investigating the research of domestic and foreign scholars on artificial intelligence in oil and gas production prediction in recent years. It provides ideas and lays a foundation for future researchers to study this aspect, and also contributes to the development of smart oil fields in the future.
Research Status and Progress of Multiples Suppression Based on Radon Transform
Authors: Wang Gang
Published: April 2023

The existence of multiple waves in seismic data has a substantial impact on earthquake imaging, inversion, and interpretation results. As a result, multiples are often suppressed as noise prior to seismic data preattack processing. Currently, there are two primary methods for suppressing multiple reflections in seismic data. One is a filtering technique based on geometric differences in the seismic waves, while the other is based on wave equation methods. The Radon transform, which suppresses multiple reflections, belongs to the class of geometric seismic diffraction filtering techniques. In the process of seismic data processing, it effectively separates multiple reflections from seismic data by utilizing the characteristic differences between primary and multiple reflections, thereby achieving noise attenuation and improving the signal-to-noise ratio of the data. This article primarily investigates the current state of methods for suppressing multiple reflections based on the Radon transform, both domestically and internationally. By introducing various forms and fundamental principles of the Radon transform, this study analyzes and compares the adaptability and pros and cons of each type of Radon transform. The high-precision Radon transform can effectively address the sawtooth phenomenon and energy dispersion issues that arise in the least-squares Radon transform. It also highlights the challenges associated with suppressing multiple reflections in the Radon transform and provides a glimpse into future developments.
Physical Property Analysis and Sensitivity Damage Evaluation of Tight Sandstone Gas Reservoirs
Authors: Huang Kai , Yang Feng
Published: April 2023

Tight sandstone reservoirs are widely distributed in China, because tight reservoirs have the characteristics of low porosity and low permeability, high clay mineral content, etc., it is easy to cause reservoir damage during hydraulic fracturing and is not easy to recover. X-ray whole-rock diffraction analysis was carried out through tight sandstone reservoir core, and the proportion of sensitive minerals in tight sandstone gas reservoir was clarified, and water sensitivity and flow velocity sensitivity damage experiments were carried out based on the test results. The experimental results show that the flow velocity sensitivity damage rate of tight sandstone reservoir is 28.02%, and the critical flow rate is 0.75ml/min, which is a weak flow rate sensitivity injury. The water-sensitive injury rate was 63.98%, which was moderately strong water-sensitive injury.
The recovery of the Middle-Late Triassic prototype basin in the western Tuha basin-eastern Junggar Basin
Authors: Zhang Jingjun , Cao Yanfang
Published: April 2023

Based on the data of mud logging, well logging and seismic data, the erosion thickness and original sedimentary thickness of the Middle-Late Triassic prototype basin in the west of Turpan-Hami Basin-Zhundong area were restored and analyzed. The erosion thickness of the Middle-Upper Triassic was calculated by the seismic stratigraphic thickness trend method, and the prototype basin was analyzed by combining the original sedimentary thickness. The results show that the erosion thickness in the west of Turpan-Hami Basin is 0m-600 m, which decreases first and then increases from north to south and then decreases. The erosion thickness of the Middle-Upper Triassic strata in the Zhundong area is 0m-400m, which increases first and then decreases from south to north. The maximum original thickness of the Middle-Upper Triassic strata in the western Tuha Basin is 1400 m in the front of the Bogda Mountain, which is thickened from north to south. The original thickness of the Middle-Upper Triassic strata in the eastern Junggar Basin generally increases from north to south. Bogda Mountain and its adjacent areas show a quasi-plainization process of cutting high and filling low. The scope of Taibei depression and Tainan depression further expanded, the sedimentary center moved southward, the Pubei low uplift became the denudation area, and the Keyayi depression and the Toksun depression developed. Beisantai uplift and Shaqi uplift in the north of Zhundong area are developed and their scope is expanding, and Zhundong depression area is developed in the south.
A Study on the Moral Construction of Middle School Ideological and Political Course Teachers
Authors: He Feiyan , Yuan Xuezhe
Published: April 2023

In the current process of moral construction of middle school ideological and political course teachers, there are still some prominent problems, such as formalization of moral construction, moral incentive mechanism fails to meet practical needs, dilution of professional spirit of some middle school ideological and political course teachers, weak awareness of education, lack of knowledge of the connotation of moral. In order to solve these problems better, we should promote the moral construction of middle school ideological and political course teachers towards the orderly goal. Schools should improve the evaluation, incentive mechanism and training system of teachers' ethics. Middle school ideological and political teachers should strengthen their own moral cultivation and theoretical knowledge, constantly improve the construction of middle school ideological and political teachers' ethics, and promote the orderly development of the construction of middle school ideological and political teachers' ethics.