bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimized multi-layer radial permanent magnet bearing with an eddy current damping systems
Authors: Bekinal Siddappa Iranna , Deshwal Dhruv , Srinivas Vijay Gaddale
Published: October 2022

This research work proposes the conventional and novel eddy current damping systems (CECDS & NECDS) for an optimized multi-layer radial permanent magnet bearing, which is axially magnetized. Firstly, the design and optimization of a bearing are carried out by adopting the general procedure for maximum radial force and stiffness by selecting stator outer diameter, radial air gap, and length as parameters. The maximum radial force and stiffness concerning an optimized structure are also calculated using semi-analytical equations, and force results are validated with three-dimensional (3D) finite element analysis results. Then, the analysis of both damping systems is carried out for damping forces and coefficients using 3D electromagnetic transient analysis in ANSYS. The proposed dampers provide adequate damping to the bearing structure, and conductor plate thickness significantly affects the damping characteristics. The NECDS could be used to replace the conventional type as it eliminates the effect of reduced radial air gap on the performance of the bearing.
Regressive Erosion at River Coca in Northeast Ecuador: Landslide Monitoring with Sentinel-1 to Support Disaster Risk Management
Authors: Graw Valerie , Dedring Torben , Hiby Roman , Jara-Alvear Jose , Guzman Pablo , Juergens Carsten
Published: October 2022

After the collapse of the San Rafael waterfall in Northeast Ecuador on 2 February 2020, a regressive erosion started along the River Coca putting national infrastructure, the environment and indigenous communities at risk. A fast monitoring of areas exposed to landslides on local scales therefore is necessary to provide adequate risk management for the region. The study area, located in the Andean tropics close to the volcano Reventador, is characterized by steep slopes, seismic activity and high rainfall throughout the year. Sentinel-1 SAR data provide a solution for time-series monitoring in the region as imagery is available day and night and not affected by cloud cover. Landslide monitoring with Sentinel-1 SAR data was implemented using a bi-temporal change detection (BCD) with SNAP and a sequential change detection (SCD) with EESA Docker and the Google Earth Engine (GEE) aiming at the identification of a suited approach for fast disaster monitoring and management. The SCD showed an overall accuracy of 0.91 compared to 0.88 using the BCD approach validated with high-resolution imagery. Based on the landslide detection, hazard variables could be further identified to support future hazard and risk assessment. Fast processing of Sentinel-1 time-series data in a cloud-based environment allows for near real-time monitoring of ongoing erosion and provides a potential for pro-active measures to protect the national economy, the environment and the society.
Lightweight design approach of an LFT-metal multi-material vehicle door concept
Authors: Li Danshi , Fang Xiangfan
Published: October 2022

This work presents a new approach to design and validate an economical lightweight multi-material roof-integrated vehicle door concept made of long-fiber thermoplastics (LFT) and metals with the consideration of package constrain, critical static and crash loading cases. A novel “two-ring” door structure is introduced, which consists of a major load-bearing region and a minor load-bearing but highly function-integrated region. This concept design concentrates on using cost-efficient lightweight materials, such as aluminum, LFTs and uni-directional tapes (UD-Tapes), as well as corresponding mass-production methods. Using the topology and parameter optimization along with the load anisotropy analysis, the rib structure on the door concept is optimized and the effective usage of UD-Tapes is guaranteed. In comparison to the steel reference, the final LFT-metal multi-material door concept achieves 20% weight reduction with a comparable or improved mechanical performance.
A questionnaire measure of adult attachment anxiety correlates with frontal hemispheric asymmetry in sleep spindle activity
Authors: Becske Melinda , Lázár Imre , Bódizs Róbert
Published: October 2022

Subjects with high levels of attachment anxiety and neuroticism were proposed to be characterized by higher relative right rather than left frontal activity. Since sleep spindles are argued to reflect enhanced offline neuroplasticity, higher spindle activity measured over the right frontal areas relative to the corresponding left frontal ones could index higher attachment anxiety and neuroticism. Our aim was to explore the relationship between the lateralization patterns of frontally dominant slow sleep spindles and questionnaire measures of adult attachment anxiety and neuroticism. Thirty-four healthy subjects (male = 19;Mage = 31.64; SDage = 9.5) were enrolled in our preliminary study. Second night EEG/polysomnography records and questionnaire measures of personality (Zuckerman–Kuhlman Personality Questionnaire) and adult attachment (Relationship Scales Questionnaire) were collected. Frontal slow sleep spindles were measured by the Individual Adjustment Method (IAM), whereas hemispheric asymmetry indexes of spindle occurrence rate, duration, and amplitude were derived as normalized left–right differences (electrode pairs: Fp1–Fp2, F3–F4, and F7–F8). Relative right lateralization of frontolateral and frontopolar slow sleep spindle density and mid-frontal slow spindle duration were associated with attachment anxiety, but spindle lateralization was less closely related to neuroticism. The relationships between frontal slow spindle laterality and attachment anxiety remained statistically significant even after controlling for the effect of neuroticism, whereas attachment avoidance–independence was not correlated with frontal slow spindle lateralization. Right frontal lateralization of slow sleep spindle activity might indicate attachment status in terms of the negative view of the self.
On the Role of Material Balances in the Synthesis of Overall Process Control Systems
Authors: Bolton Leslie , Smith Robin
Published: October 2022

The synthesis of control systems for overall processes remains a challenge. Whilst a number of automated approaches have been explored academically, in practice systems are mainly synthesised using experience and intuition in conjunction with dynamic simulation software. An approach is presented in this paper for the systematic synthesis of overall process control systems which is simple, practical and appropriate for use at the undergraduate teaching level. Many potential problems can be identified and avoided in the synthesis of process control systems by ensuring that the control system can maintain a steady-state control of the overall mass, the mass of the individual components and, where necessary, multiple phases. Processes with recycles are vulnerable to process control problems when the overall mass balance of the system containing the recycle is not correctly managed. This can be overcome by self-regulation (perhaps involving process design changes) or by changing the structure of the control system. Achieving and maintaining the material balance are the main purposes of the majority of controllers in most chemical processes. Without robust delivery of material balance control, higher level control objectives (such as quality controls) are unlikely to be met reliably. This paper presents a step-wise approach to the synthesis of overall process control systems that avoids many potential problems by identifying which process parameters can be manipulated to achieve the intended process mass balance and designing the control structure accordingly.
The emergence of entrepreneurship education programs in Indonesian higher education institutions
Authors: Maritz Alex , Li Alice , Utami Whidya , Sumaji Yoseva
Published: October 2022

The purpose of this paper is to explore the status of entrepreneurship education programs (EEPs) in Indonesia, expanding similar papers on related Australian EEPs in 2019 and Malaysian EEPs in 2021. The aim is to review neoteric global best practice entrepreneurship education (EE), aligning context and specific inference of EEPs in Indonesian Higher Education Institutions (HEIs) within dynamic entrepreneurial ecosystems. We provide a descriptive and emergent inquiry approach consisting of a review of prominent scholarship within the context of EEPs in Indonesia, together with a first of its kind quantitative component depicting the distribution of entrepreneurship spirit, EEPs, accelerators and entrepreneurship support services within HEIs. The paper highlights the sparse and inconsistent distribution across EEPs in Indonesia, further characterized by only a few dominant HEIs specializing in EE. The findings provide critical insights for HEI leaders, researchers, practitioners, and administrators wishing to enhance entrepreneurship and start-up resources at Indonesian HEIs. Further research, however, is recommended especially with respect to the efficacy and impact of these EEPs.
Seismic vulnerability assessment of buildings: case study of Al Khalifa district, Fatimid Cairo
Authors: Hassan Maha M. , Elyamani Ahmed , Mourad Sherif A.
Published: October 2022

This work intends to provide seismic vulnerability analysis for a building stock in Al Khalifa District, Fatimid Cairo while focusing on the historic buildings in the area. The work represents part of an interdisciplinary study targeting the management and conservation of a UNESCO World Heritage Site. The project inspects several aspects including behavior of masonry walls, structural health monitoring of selected structures, conservation studies, in addition to influence of rising ground water. In the current study, seismicity of Egypt generally and Cairo specifically is reviewed. Afterwards, large-scale seismic vulnerability is adopted to calculate the vulnerability index for buildings within the study area. Data are collected through extensive on-site surveys for more than one hundred buildings. Observed typologies are listed alongside possible mechanisms of failure. Egypt has moderate seismic hazard; however, many buildings are prone to damage due to inadequate seismic design. This leads to retrofitting requirements to reduce seismic vulnerability and adhere to imposed seismic requirements in design codes. The study is intended to understand seismic risk of buildings within study area as part of a comprehensive study. Developed vulnerability map show that many buildings are prone to damage during seismic events.

Article Highlights

Seismic vulnerability of building samples in a study area within Old Cairo is assessed and presented in the form of a vulnerability map.

Structural characteristics of buildings are detailed and investigated.

Signs of deterioration are analyzed, and mechanisms of failure are featured.
Evolution of a cognitive architecture on the basis of a functional core
Authors: Serov Alexander
Published: October 2022

Industry 4.0 assumes the use of intelligent components integrated into a single system and capable of interacting with each other without human intervention. Autonomous cognitive agents are the technological basis for building such systems. One of the main problems of modern cognitive architectures is an excessively schematic approach to modeling the processes of cognitive activity. It does not allow the creation of a universal architecture that would be capable of reproducing higher nervous functions without using a predetermined set of perception patterns. This paper proposes an evolutionary approach to creating a cognitive architecture. The basis of this approach is the use of some functional core, which consistently generates the intellectual functions of an autonomous agent. We are considering a cognitive architecture that includes components, the interaction of which ensures the evolution of the agent. The discussion of the development of intelligence is carried out using the conceptual apparatus of semiotics. This allows us to consider the task of developing cognitive functions as a problem of establishing a connection between the Merkwelt and the Werkwelt through the creation of the Innenwelt. The problem of early postnatal ontogenesis is investigated on the basis of the theory of constructivism: we discuss the requirements for the functional core and its composition, as well as the mechanism that initiates the process of cognition. We have developed a numerical method for modeling cognitive activities present at an early stage of ontogenesis. The method was used for the creation of the Cognitive Sensory System.
Approaches to tailor the cooling supply to the grinding process
Authors: Denkena Berend , Bergmann Benjamin , Gartzke Tobias , Wilckens Michael
Published: October 2022

This study presents original research of the investigation of the coolant supply to the contact area with two different approaches. The cooling and lubrication are key aspects of manufacturing processes such as grinding to achieve a high surface quality at high productivity. The coolant supply to the contact area has a high impact on the performance of the coolant. This paper presents the results from two approaches to tailoring the coolant supply for conventional and high-performance processes. An analytical approach is established to determine the coolant outlet velocity. Afterward, a sensor is developed to measure the coolant velocity at the nozzle. Conclusively, the influence of the coolant velocity on the volume flow through the contact zone is investigated. The results of this study highlight the importance of coolant outlet velocities of at least 60% of the cutting speed. The two approaches outline low impact possibilities to ensure optimal coolant outlet velocities and thus low thermal loads during the grinding process.

Article Highlights

Analytical approach to calculate outlet velocities for varying noozles in high-performance grinding with cutting speeds of up to 100 m/s

Utilization of a high-speed camera to determine the outlet nozzle velocities in a conventional deep grinding process

Validation of the impact of the coolant outlet velocity on the volume flow through the contact area by means of a coolant collection box
Viewpoint: The Case for Non-Invasive Central Aortic Pressure Monitoring in the Management of Hypertension
Authors: Kesten Steven , Qasem Ahmad , Avolio Alberto
Published: October 2022

Elevated central aortic pressure indices (e.g., systolic pressure and pulse pressure) predict cardiovascular (CV) events and mortality in addition to structural changes (e.g., left ventricular hypertrophy, carotid intima-media thickness and reduced glomerular filtration rate). These elevated risks have been shown in multiple studies to be superior to, and in others, at least as high as that associated with brachial pressures. Threshold values for the diagnosis of elevated central arterial pressures have been defined and can be considered target goals of treatment. Measurements of central arterial pressures can be incorporated into the current approaches to hypertension management utilizing currently available non-invasive devices that measure central pressures during the measurement of brachial BP. The objective of this review is to outline the rationale and evidence supporting incorporation of central aortic pressure monitoring into the care of patients with hypertension.
Freezing Injunctions in Private International Law
Authors: Šaranović Filip
Published: October 2022

The extent of available pre-judgment asset preservation relief is widely regarded as a unique characteristic of English law and one of the key factors attracting international commercial litigation to the English courts. By taking a novel view of the theoretical foundations of a freezing injunction, this book challenges the long-established view that such an injunction is an in personam form of relief whose sole purpose is to prevent unscrupulous defendants from making themselves judgment-proof. Dr Šaranović combines historical and comparative perspectives to identify several theoretical flaws in the court's jurisdiction to grant this popular form of interim relief. The book demonstrates that the current application of private international law rules in this field leads to inequality among litigants and illegitimate encroachment upon the sovereignty of foreign states. It proposes a range of possible solutions to alleviate concerns about the scope of freezing injunctions both in the domestic and international arena.
Mediating Innovation through Language Teacher Education
Authors: East Martin
Published: October 2022

This Element examines how pedagogical innovation in language classrooms can be mediated through language teacher education (LTE) by subjecting the author's own practices as a teacher educator to scrutiny. Starting from the premise that implementing innovation can be a challenging enterprise, effective LTE is framed as being built on helping practitioners to recognise and confront often deeply-rooted beliefs and adjust subsequent practices through critical reflection on what an innovation may look like both theoretically and practically. A critically reflective lens is then applied to the author's own work as a teacher educator over several years through a research approach known as self-study of teacher education practices or S-STEP. The approach highlights changes to the author's beliefs and practices as lessons emerged from beginning teachers' engagement with innovative ideas. These are presented with the aim of better understanding how teachers' beliefs and practices with regard to innovation can be enhanced effectively.
Hydrologic modeling of a perennial firn aquifer in southeast Greenland
Authors: Miller Olivia , Voss Clifford I. , Solomon D. Kip , Miège Clément , Forster Richard , Schmerr Nicholas , Montgomery Lynn
Published: October 2022

A conceptual model, based on field observations and assumed physics of a perennial firn aquifer near Helheim Glacier (southeast Greenland), is evaluated via steady-state 2-D simulation of liquid water flow and energy transport with phase change. The simulation approach allows natural representation of flow and energy advection and conduction that occur in vertical meltwater recharge through the unsaturated zone and in lateral flow within the saturated aquifer. Agreement between measured and simulated aquifer geometry, temperature, and recharge and discharge rates confirms that the conceptual field-data-based description of the aquifer is consistent with the primary physical processes of groundwater flow, energy transport and phase change. Factors that are found to control simulated aquifer configuration include surface temperature, meltwater recharge rate, residual total-water saturation and capillary fringe thickness. Simulation analyses indicate that the size of perennial firn aquifers depends primarily on recharge rates from surface snowmelt. Results also imply that the recent aquifer expansion, likely due to a warming climate, may eventually produce lakes on the ice-sheet surface that would affect the surface energy balance.
Africa and Ethnic Politics
Authors: Koter Dominika
Published: October 2022

This article provides an overview of the theoretical and empirical contributions made by scholars of ethnic politics in Africa. I first discuss the definitions and measures of ethnic politics most commonly used. I then review the main explanations of the prevalence of ethnic politics. The following sections discuss the consequences of politicized ethnicity, variation in ethnic politics, and the relationship between ethnicity and other social identities, such as national identity. I conclude with some remarks about existing gaps and promising future avenues of research.
A numerical study of hypersonic laminar film cooling
Authors: Yang X. , Badcock K. J. , Richards B. E.
Published: October 2022

A computational study has been performed to investigate the effectiveness of film cooling in hypersonic laminar flows. Both the primary and the coolant flow are air. First, three different primary flow conditions are used for validation. A uniform boundary condition at the slot exit is found to give unrealistic predictions of the heat transfer rate, whilst a boundary condition involving extended coolant inlet gives improvement. Then five coolant injection rates and three slot heights are examined. It is confirmed that increasing the coolant injection rate can increase the film cooling effectiveness for laminar cases. But slot height does not play an important role under the flow conditions in this study. The computational results are compared with the experimental results and good agreement is achieved.
Local News and the Electoral Incentive to Invest in Infrastructure
Authors: MULLIN MEGAN , HANSEN KATY
Published: October 2022

Despite broad public support, investment in US infrastructure has not kept pace with growth, population shifts, and rising exposure to climate change risks. One explanation lies in politicians’ electoral incentives: because, in the short term, voters see only the costs of investment and not its benefits, politicians have incentive to pander and spend less than what they or their fully informed constituents would prefer. Local newspapers could help reduce this constraint by increasing politicians’ confidence that voters will receive information that justifies higher spending. In a survey experiment, we found that informing US city and county elected officials about news coverage of infrastructure failures increased support for a costly investment for those in competitive electoral settings. When motivated by reelection, politicians need the benefits of investment to be visible in order to justify its costs. Our results demonstrate the political importance of the nonpolitical news covered in local newspapers.
Iron-enriched Aspergillus oryzae as an alternative to iron sulphate to limit iron accumulation, growth and motility of the enteric pathogen S. Typhimurium
Authors: Miller Katelyn M. , Reddy Manju B. , Quashie David , Velez Frank J. , Ali Jamel , Singh Prashant , Hennigar Stephen R.
Published: October 2022

Excess unabsorbed iron in the gastrointestinal tract may select for enteric pathogens and increase the incidence and severity of infectious disease. Aspergillus oryzae (Ao) is a filamentous fungus that has the ability to accumulate and store large amounts of iron, and when used as a supplement or fortificant, has similar absorption to ferrous sulphate (FeSO4) in humans. The objective of this study was to determine the effect of iron-enriched Ao (Ao iron) compared with FeSO4 on iron accumulation, growth and motility of the Gram-negative enteric pathogen, S. Typhimurium. S. Typhimurium was cultured in media containing no added iron or 1 μM elemental iron as either Ao iron or FeSO4. S. Typhimurium cultured with FeSO4 accumulated more iron than those cultured with Ao iron. Genes regulated by the iron-activated transcriptional repressor, Fur, did not differ between control and Ao iron, but decreased in S. Typhimurium cultured with FeSO4 compared with both groups. Growth of S. Typhimurium was greater when cultured with FeSO4 compared with Ao iron and control. S. Typhimurium swam faster, had greater acceleration and travelled further when cultured with FeSO4 compared with Ao iron and control; swim speed, acceleration and distance travelled did not differ between Ao iron and control. These findings provide evidence that Ao iron reduces the virulence of a common enteric pathogen in vitro. Further research is required to determine whether iron-enriched Ao is a suitable iron supplement to improve iron delivery in areas with a high infection burden.
Characterising the use, users and effects of a health app supporting lifestyle changes in pregnant women
Authors: Koivuniemi Ella , Raats Monique M. , Ollila Helena , Löyttyniemi Eliisa , Laitinen Kirsi
Published: October 2022

The study objective was to (1) compare, through a randomised pilot intervention study, the effects of a standard health app and an enhanced health app, with evidence-based information regarding healthy lifestyle, on gestational weight gain, diet quality and physical activity in pregnant women. The sub-objectives were to (2) characterise app use and users among pregnant women and to (3) compare, in the overall sample regardless of the intervention, whether the frequency of the health app use has an effect on the change in gestational weight, diet quality and physical activity. Women recruited through social media announcements (n 1038) were asked to record their lifestyle habits in the app from early pregnancy to delivery. Self-reported weight, diet quality and physical activity were assessed in early and late pregnancy with validated online questionnaires. No benefits of the enhanced app use were shown on the lifestyle habits. Nevertheless, frequent app users (use ≥ 4·7 weeks) in the enhanced app group had a higher physical activity level in late pregnancy compared with those in the standard app group. Overall, extensive variation was found in the number of recordings (median 59, interquartile range 19–294) and duration of app use (median 4·7, interquartile range 1·1–15·6 weeks). Frequent app users had higher education level, underweight/normal weight, better diet quality and were non-smokers, married and primipara more likely than occasional app users/non-users. Physical activity among app users decreased less compared with non-users over the pregnancy course, indicating that app use could motivate to maintain physical activity during pregnancy.
Water balance and urinary parameters of lambs fed diets containing cactus cladodes varieties
Authors: Silva T. G. P. , Lopes L. A. , Carvalho F. F. R. , Guim A. , Soares P. C. , Silva Júnior V. A. , Batista A. M. V.
Published: October 2022

The water balance and urinary parameters of lambs fed diets containing cactus cladodes varieties were evaluated. Thirty-six uncastrated male Santa Inês lambs (22.0 ± 2.9 kg initial body weight) were distributed in a completely randomized design, with three treatments and 12 replicates. The animals were fed a control diet (Tifton-85 hay as exclusive roughage), Miúda or Orelha de Elefante Mexicana (OEM) cactus-based diets. Urine samples were collected 45 days after the introduction of the tested diets, and voluntary water intake was measured over 10 days, during the experimental period. Diets containing Miúda or OEM cactus caused a reduction of 68.35 and 77.03% in voluntary water intake, respectively. In addition, the Miúda cactus cladodes caused urinary alkalinization (pH = 8.14) and reduction in the urinary excretion index (UEI) and on the fractional excretion rate (FER) of total calcium (Ca). The diets with OEM cactus cladodes caused higher oxalates intake (6.21 g/day) and increase in urinary volume. Regardless of the variety, there was a reduction in the urinary concentrations of urea, creatinine, total proteins, Ca, phosphorus (P), UEI of urea and P, as well as in FER of P, compared to the control diet. Urinary Mg content and UEI of uric acid and Mg increased and FER ofPdecreased by diets supplemented with different varieties of cactus cladodes. In conclusion, the cactus cladodes increased water intake and retention, and diuresis in lambs, altered urine parameters, without compromising kidney function.
Studying the seasonality of conceptions among five distinct population subgroups in mainland Greece: a story of similarities and variability
Authors: Zafeiris K. N. , Tsimbos C. , Verropoulou G. , Hatzisavva K.
Published: October 2022

The paper studies seasonality of conceptions among five distinct population subgroups of mainland Greece for the period 1951-2002. The populations explored include those residing in Metsovo, Dion, Organi, Kehros, as well as a “General” Sample consisting of persons located in various areas of continental Greece. The populations under investigation present diverse characteristics regarding religion, cultural background, socio-economic status etc. Records of births were derived from the Vital Registration System of the respective municipalities and communities of the populations under research were constructed. The date of child conception was estimated as the recorded date of birth minus 260 days.

The analysis focuses, among others, on the construction of seasonal indices, applying a variant ratio to moving averages method which reveal, in relative terms, the seasonality of the phenomenon. Subsequently, these ratios are considered as the dependent variable in regression models while months, expressed in terms of dummy variables, are introduced as predictors. Four main sub-periods are considered; 1951-64, 1965-80, 1981-92 and 1992-2002. The findings show that the extent of seasonality differs between periods as well as between the five population subgroups though the phenomenon becomes less prominent over time in all cases. There is a tendency of an increased number of conceptions among mountainous populations during summer, irrespective of religion or socio-economic status, possibly partly due to environmental factors (i.e. seasonal workload, domestic organisation of extended families, etc). Nevertheless, the mountainous populations differ regarding the intensity and duration of this phenomenon. By contrast, in Dion, a lowland Christian Orthodox population, conceptions increase after Easter and remain elevated until June.
Impact of manual crimping on stapedotomy outcomes
Authors: Couvreur F , Schlegel-Wagner C , Linder T
Published: October 2022

Background

The impact of tight stapes crimping on hearing is a matter of debate. Several studies postulate that tight crimping is essential for lifelong success, whereas others have debated whether firm attachment leads to incus necrosis. Several types of prostheses with different coupling mechanisms have been developed, and manual crimping remains the most frequently used technique. This study investigates whether tightness really does affect hearing outcome.

Methods

The hearing results of patients who underwent primary stapedotomies using three different titanium pistons were analysed. The surgeons categorised the firmness of the piston attachment into ‘tight’ and ‘loose’ crimping groups. Hearing outcome and reasons for revision surgical procedures were investigated.

Results

The mean post-operative air–bone gap for frequencies of 0.5–4 kHz was 8.80 dB for the tight crimping group (n = 308) and 9.55 dB for the loose crimping group (n = 39). No significant difference was found (p = 0.4650). Findings at revision procedures were comparable (1.6 per cent vs 5 per cent).

Conclusion

Although firm crimping is strongly advised, a movable loop upon palpation does not lead to unsatisfactory hearing results, and does not mandate piston replacement or bone cement use.
The Stuff of Legal History
Authors: Bishara Fahad Ahmad
Published: October 2022

This concluding reflection on the forum, “The Everyday Materials of Colonial Legal History,” seeks to emphasize the contributing essays engagement with historical methodologies that take seriously objects, signs, and the theatrical.
Hazardous Changes in Soil CO2 Emissions at Vulcano, Italy, in 2021
Authors: Di Martino R. M. R. , Gurrieri S. , Camarda M. , Capasso G. , Prano V.
Published: October 2022

The La Fossa volcano on the Island of Vulcano, Italy, showed signs of more energetic fumarolic–solfataric activity during 2021. Several increases in volcanic gas emissions and seismicity, namely, “crisis,” punctuated the passive degassing at Vulcano that had ensued after the last 1888–1890 vulcanian eruption. Most of the gases (i.e., up to 90%) were emitted at the crater cone while the diffuse degassing of CO2 at Vulcano Porto accounted for more than 10% of the volcanic emissions. Two anomalous degassing zones at the base of the volcanic cone (i.e., Palizzi and Faraglione) showed notable changes in the gas output during the volcanic crisis. In these zones, increases of soil CO2 flux (φCO2) had several practical implications other than of volcanological interest, owing to the risk related to people's exposure to volcanic gas emissions. The results of this study reveal variations of the average φCO2 from 74 g m−2 d−1 during September 2021 to 370 g m−2 d−1 in November 2021, which were 27% and 538% higher than the statistical background since 1988 (φCO2 ≈ 58 g m−2 d−1), respectively. These observations helped in volcanic surveillance at Vulcano. The soil CO2 partitioning determined using both φCO2 and carbon isotope measurements, helped track changes in the volcanic CO2 output from 9.97 · 104 to 101.15 · 104 kg d−1. Estimates for volcanic CO2 suggest that the instability of a magmatic body caused a transition from background fumarolic–solfataric activity toward an unrest event after September 2021.
Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease
Authors: Skrabal Dominik , Rusz Jan , Novotny Michal , Sonka Karel , Ruzicka Evzen , Dusek Petr , Tykalova Tereza
Published: October 2022

Imprecise vowels represent a common deficit associated with hypokinetic dysarthria resulting from a reduced articulatory range of motion in Parkinson’s disease (PD). It is not yet unknown whether the vowel articulation impairment is already evident in the prodromal stages of synucleinopathy. We aimed to assess whether vowel articulation abnormalities are present in isolated rapid eye movement sleep behaviour disorder (iRBD) and early-stage PD. A total of 180 male participants, including 60 iRBD, 60 de-novo PD and 60 age-matched healthy controls performed reading of a standardized passage. The first and second formant frequencies of the corner vowels /a/, /i/, and /u/ extracted from predefined words, were utilized to construct articulatory-acoustic measures of Vowel Space Area (VSA) and Vowel Articulation Index (VAI). Compared to controls, VSA was smaller in both iRBD (p = 0.01) and PD (p = 0.001) while VAI was lower only in PD (p = 0.002). iRBD subgroup with abnormal olfactory function had smaller VSA compared to iRBD subgroup with preserved olfactory function (p = 0.02). In PD patients, the extent of bradykinesia and rigidity correlated with VSA (r = −0.33, p = 0.01), while no correlation between axial gait symptoms or tremor and vowel articulation was detected. Vowel articulation impairment represents an early prodromal symptom in the disease process of synucleinopathy. Acoustic assessment of vowel articulation may provide a surrogate marker of synucleinopathy in scenarios where a single robust feature to monitor the dysarthria progression is needed.
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Authors: Seim Gretchen L. , John Steven V. , Arp Nicholas L. , Fang Zixiang , Pagliarini David J. , Fan Jing
Published: October 2022

Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism. These multi-subunit enzyme complexes use lipoic arms covalently attached to their E2 subunits to transfer an acyl group to coenzyme A (CoA). Here, we report a novel mechanism capable of substantially inhibiting PDHC and OGDC: reactive nitrogen species (RNS) can covalently modify the thiols on their lipoic arms, generating a series of adducts that block catalytic activity.S-Nitroso-CoA, a product between RNS and the E2 subunit’s natural substrate, CoA, can efficiently deliver these modifications onto the lipoic arm. We found RNS-mediated inhibition of PDHC and OGDC occurs during classical macrophage activation, driving significant rewiring of cellular metabolism over time. This work provides a new mechanistic link between RNS and mitochondrial metabolism with potential relevance for numerous physiological and pathological conditions in which RNS accumulate.
Incidence of depression in kidney transplant recipients in South Korea: a long-term population-based study
Authors: Cho Semin , Park Sehoon , Kim Ji Eun , Yu Mi-yeon , Baek Seon Ha , Han Kyungdo , Lee Hajeong , Kim Dong Ki , Joo Kwon Wook , Kim Yon Su , Kim Yong Chul
Published: October 2022

Depression is associated with impaired quality of life and increased morbidity and mortality in end-stage kidney disease (ESKD) patients and kidney transplantation (KT) recipients. Depression incidence after KT is unclear. We compared depression incidence among KT recipients, ESKD patients, and healthy controls (HCs). We analyzed a nationwide health insurance database in South Korea and identified patients who underwent KT during 2007–2015. Participants were matched for age, sex, and inclusion year. KT and ESKD patients were further matched for hypertension and diabetes mellitus history. The incidence rate (IR, per 1000 patients-years) of depression was compared among KT, ESKD, and HC groups. We analyzed 5,234 patients per group. Depression incidence was markedly lower in KT than ESKD patients (IR, 18.87 vs. 58.03; hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.30‒0.36), but only slightly higher in KT recipients than in HCs (IR, 18.87 vs. 17.49; HR, 1.08; 95% CI, 0.96‒1.22). After adjusting for comorbidities, the depression risk was lower in KT recipients than in HCs (adjusted HR, 0.52; 95% CI, 0.44‒0.62; p < 0.001), whereas it remained higher in ESKD patients than in HCs (adjusted HR, 1.60; 95% CI, 1.36‒1.87; p < 0.001). Among KT recipients, older age, female sex, lower economic status, and more comorbidities were associated with increased depression risk. Incident depression after KT increased mortality, graft failure, and death-censored graft failure risks in KT recipients. Our data suggest a broader role of KT than previously appreciated in terms of improving quality of life by reducing depression risk.
The relationship between the intensity of Gasterophilus intestinalis larvae infection and the serum and salivary humoral immune response in horses
Authors: Pawlas-Opiela Monika , Jawor Paulina , Galli Józef , Zak-Bochenek Agnieszka , Gorczykowski Michał , Galli Joanna , Sołtysiak Zenon , Stefaniak Tadeusz
Published: October 2022

Infection with Gasterophilus intestinalis (botfly) larvae often occurs in horses. The aim of the study was to isolate the larvae of G. intestinalis and evaluate the serum and salivary humoral immune response using self-developed ELISA in G. intestinalis infected horses. Blood serum or saliva samples were taken from 125 infected horses and 54 uninfected slaughtered horses. The antigens from G. intestinalis larvae were used for development of ELISA in order to evaluate the intensity of G. intestinalis IgG, IgM, and IgA antibody reactivity in the serum or saliva of naturally infected horses and horses without larvae in the gastrointestinal tract (control group). Serum antibodies against second and third larvae’s stadium antigens reacted significantly more intensively in infected than in healthy horses in IgG (p ≤ 0.001; p ≤ 0.05, respectively) and IgA (p ≤ 0.05;p ≤ 0.001, respectively) classes. Salivary IgG and IgA specific’s antibody reactivity was significantly higher in horses with moderate (p ≤ 0.01) and severe infection (p ≤ 0.001) compared to the healthy horses. The determination of the G. intestinalis IgG and IgA antibody activity in saliva and serum may be used for detecting horses moderately and severely infested with larvae.
Influence of hydroxyapatite nanoparticles on the formation of calcium fluoride surface layer on enamel and dentine in vitro
Authors: Rodemer Tina , Pütz Norbert , Hannig Matthias
Published: October 2022

Topical application of different fluoride preparations is considered to be the gold standard of oral prophylaxis measures in preventive dentistry. Hydroxyapatite nanoparticles (nano-HAP) as well, have received considerable attention for dental use in the past few decades. The purpose of this in-vitro study was to analyze the interaction between nano-HAP and different fluoride preparations. In order to investigate the possibility to establish, in the presence of nano-HAP, reproducible calcium fluoride surface layers, specimens were visually examined with regard to the surface coverage’s structure, morphology, homogeneity and stability. Test series based on enamel and dentine specimens, that were obtained from extracted bovine teeth, were conducted. Thereby, sodium fluoride, olaflur, elmex Fluid (10.000 ppm) and an aqueous nano-HAP solution (5%) served as test products and sterile water as reference. First, single application of nano- HAP and fluoride was tested. After 5 min of incubation in the test solution, the surface coverage was examined by scanning electron microscopy (SEM). Furthermore, samples were determined by energy dispersive X-ray spectroscopy (EDX) to identify the present elements of the surface layer, particularly fluoride. To test the calcium fluoride layer’s persistence and stability, samples were exposed to the spray of a dental multifunctional syringe for 20 s using maximum pressure and maximum water supply. In the second application protocol, fluoride and nano-HAP were applied simultaneously and in the third application protocol they were used sequentially. SEM visualisation showed that the simultaneous or sequential addition of nano-HAP led to a distinct change in the surface layer’s structure. Agglomerates of various sizes were formed, with obviously different morphology from the calcium fluoride globules, not covering the surface homogeneously and sprayed off with the multifunctional syringe easily. Application of pure fluoride compounds resulted in a more homogeneous calcium fluoride surface layer with higher persistence in comparison to the combination of fluoride and nano-HAP. Interaction between fluoride and nano-HAP clearly could be proved. On enamel as well as dentine surfaces, the combined application of nano-HAP and fluoride has a negative effect on the stability and persistence of the calcium fluoride surface precipitate.
Commensal oral microbiota impacts ulcerative oral mucositis clinical course in allogeneic stem cell transplant recipients
Authors: Bruno Julia S. , Heidrich Vitor , Knebel Franciele H. , de Molla Vinícius Campos , Parahyba Claudia Joffily , Miranda-Silva Wanessa , Asprino Paula F. , Tucunduva Luciana , Rocha Vanderson , Novis Yana , Arrais-Rodrigues Celso , Camargo Anamaria A. , Fregnani Eduardo R.
Published: October 2022

Oral mucositis (OM) is a complex acute cytotoxicity of antineoplastic treatment that affects 40–85% of patients undergoing hematopoietic stem-cell transplantation. OM is associated with prolonged hospitalization, increased extensive pharmacotherapy, need for parenteral nutrition, and elevated treatment costs. As OM onset relates to the mucosal microenvironment status, with a particular role for microbiota-driven inflammation, we aimed to investigate whether the oral mucosa microbiota was associated with the clinical course of OM in patients undergoing allogeneic hematopoietic stem-cell transplantation. We collected oral mucosa samples from 30 patients and analyzed the oral mucosa microbiota by 16S rRNA sequencing. A total of 13 patients (43%) developed ulcerative OM. We observed that specific taxa were associated with oral mucositis grade and time to oral mucositis healing. Porphyromonas relative abundance at preconditioning was positively correlated with ulcerative OM grade (Spearman ρ = 0.61, P = 0.028) and higher Lactobacillus relative abundance at ulcerative OM onset was associated with shortened ulcerative OM duration (P = 0.032). Additionally, we generated a machine-learning-based bacterial signature that uses pre-treatment microbial profiles to predict whether a patient will develop OM during treatment. Our findings suggest that further research should focus on host-microbiome interactions to better prevent and treat OM.
Heat transfer and hybrid ferrofluid flow over a nonlinearly stretchable rotating disk under the influence of an alternating magnetic field
Authors: Rauf Abdul , Mushtaq Aqsa , Shah Nehad Ali , Botmart Thongchai
Published: October 2022

Under the influence of an alternating magnetic field, flow and heat transfer of a ferrofluid flow over a flexible revolving disc are examined. The flow is hampered by the external magnetic field, which is dependent on the alternating magnetic field's frequency. The current work examines the heat transfer and three-dimensional flow of fluid with high viscosity on a spinning disc that is stretched in a radial direction. The governing equations' symmetries are computed using Lie group theory. In the problem, there is a resemblance that can accomplish with radially stretching velocities divided into two categories, specifically, linear and power-law, by imposing limits from the boundary conditions. The literature has already covered linear stretching, but this is the first discussion of power-law stretching. The governing partial differential is turned into an ordinary differential equations system using additional similarity transformations, which are then numerically handled. The results are presented for hybrid alumina–copper/ethylene glycol ($${\text{Al}}_{2} {\text{O}}_{3} - {\text{Cu}}/{\text{EG}}$$

Al
2

O
3

-
Cu
/
EG

) nanofluid. The calculated findings are novel, and it has been seen that they accord quite well with those of the earlier extended literature. It has been found that hybrid nanofluid flow outperforms nanofluid flow in terms of Nusselt number or heat transfer rate. The heat transmission in the fluid is reduced as the Prandtl number is increased. The heat transfer increases as dimensionless magnetic field intensity $$\xi$$
ξ
increases. Also, axial velocity and radial velocity decrease as magnetic field intensity increases. As the ferromagnetic interaction parameter is raised, the efficiency of heat transmission decreased. For non-linear stretching with stretching parameter 0 < m < 1, the velocity decreases with the increase in m.
A randomized trial assessing the efficacy of Silymarin on endometrioma-related manifestations
Authors: Mirzaei Negin , Jahanian Sadatmahalleh Shahideh , Rouholamin Safoura , Nasiri Malihe
Published: October 2022

To study the effect of silymarin on the Interleukin-6 (IL-6) level, size of endometrioma lesion, pain, sexual function, and Quality of Life (QoL) in women diagnosed with endometriosis. This randomized, double-blind placebo-controlled clinical trial was performed on 70 women with endometriosis which was divided into two groups of intervention and control. The intervention was 140 mg silymarin (or matching placebo) administered twice daily for 12 weeks. The volume of endometrioma lesions, the level of IL-6 concentration in serum, pain, sexual function, and QoL were analyzed before and after the intervention. The means of endometrioma volume (P = 0.04), IL-6 (P = 0.002), and pain (P < 0.001) were reduced significantly in the silymarin group after intervention. However, the QoL and female sexual function did not improve substantially in the two groups (P > 0.05). Silymarin significantly reduced interleukin-6 levels, sizes of endometrioma lesions, and pain-related symptoms. The trial has been registered in the Iranian Registry of Clinical Trials (IRCT20150905023897N5) on 4th February 2020 (04/02/2020) (https://en.irct.ir/trial/42215) and the date of initial participant enrollment was 2nd March 2020 (02/03/2020).