bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole-Exome Sequencing for Diagnosis of Turner Syndrome: Toward Next-Generation Sequencing and Newborn Screening
Authors: Murdock David R. , Donovan Frank X. , Chandrasekharappa Settara C. , Banks Nicole , Bondy Carolyn , Muenke Maximilian , Kruszka Paul
Published: April 2017

Context:

Turner syndrome (TS) is due to a complete or partial loss of an X chromosome in female patients and is not currently part of newborn screening (NBS). Diagnosis is often delayed, resulting in missed crucial diagnostic and therapeutic opportunities.

Objectives:

This study sought to determine if whole-exome sequencing (WES) as part of a potential NBS program could be used to diagnose TS.

Design, Setting, Patients:

Karyotype, chromosomal microarray, and WES were performed on blood samples from women with TS (n = 27) enrolled in the Personalized Genomic Research study at the National Institutes of Health. Female control subjects (n = 37) and male subjects (n = 27) also underwent WES. Copy number variation was evaluated using EXCAVATOR2 and B allele frequency was calculated from informative single nucleotide polymorphisms. Simulated WES data were generated for detection of low-level mosaicism and complex structural chromosome abnormalities.

Results:

We detected monosomy for chromosome X in all 27 TS samples, including 1 mosaic for 45,X/46,XX and another with previously unreported material on chromosome Y. Sensitivity and specificity were both 100% for the diagnosis of TS with no false-positive or false-negative results. Using simulated WES data, we detected isochromosome Xq and low-level mosaicism as low as 5%.

Conclusion:

We present an accurate method of diagnosing TS using WES, including cases with low-level mosaicism, isochromosome Xq, and cryptic Y-chromosome material. Given the potential use of next-generation sequencing for NBS in many different diseases and syndromes, we propose WES can be used as a screening test for TS in newborns.
Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty
Authors: Dauber Andrew , Cunha-Silva Marina , Macedo Delanie B. , Brito Vinicius N. , Abreu Ana Paula , Roberts Stephanie A. , Montenegro Luciana R. , Andrew Melissa , Kirby Andrew , Weirauch Matthew T. , Labilloy Guillaume , Bessa Danielle S. , Carroll Rona S. , Jacobs Dakota C. , Chappell Patrick E. , Mendonca Berenice B. , Haig David , Kaiser Ursula B. , Latronico Ana Claudia
Published: April 2017

Context:

Central precocious puberty (CPP) results from premature activation of the hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with the most common being mutations in the paternally expressed imprinted gene MKRN3.

Objective:

To identify the genetic etiology of CPP in a large multigenerational family.

Design:

Linkage analysis followed by whole-genome sequencing was performed in a family with five female members with nonsyndromic CPP. Detailed phenotyping was performed at the time of initial diagnosis and long-term follow-up, and circulating levels of Delta-like 1 homolog (DLK1) were measured in affected individuals. Expression of DLK1 was measured in mouse hypothalamus and in kisspeptin-secreting neuronal cell lines in vitro.

Setting:

Endocrine clinic of an academic medical center.

Patients:

Patients with familial CPP were studied.

Results:

A complex defect of DLK1 (∼14-kb deletion and 269-bp duplication) was identified in this family. This deletion included the 5′ untranslated region and the first exon of DLK1, including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1. The patients did not demonstrate additional features of the imprinted disorder Temple syndrome except for increased fat mass. Serum DLK1 levels were undetectable in all affected individuals. Dlk1 was expressed in mouse hypothalamus and in kisspeptin neuron-derived cell lines.

Conclusion:

We identified a genomic defect in DLK1 associated with isolated familial CPP. MKRN3 and DLK1 are both paternally expressed imprinted genes. These findings suggest a role of genomic imprinting in regulating the timing of human puberty.
A Randomized Phase 2 Study of Long-Acting TransCon GH vs Daily GH in Childhood GH Deficiency
Authors: Chatelain Pierre , Malievskiy Oleg , Radziuk Klaudziya , Senatorova Ganna , Abdou Magdy O. , Vlachopapadopoulou Elpis , Skorodok Yulia , Peterkova Valentina , Leff Jonathan A. , Beckert Michael ,   the TransCon GH Working Group
Published: April 2017

Context:

TransCon Growth Hormone (GH) (Ascendis Pharma) is a long-acting recombinant sustained-release human GH prodrug in development for children with GH deficiency (GHD).

Objective:

To compare the pharmacokinetics, pharmacodynamics, safety, and efficacy of weekly TransCon GH to that of daily GH in prepubertal children with GHD.

Design:

Randomized, open-label, active-controlled study of three doses of weekly TransCon GH versus daily Genotropin (Pfizer).

Setting:

Thirty-eight centers in 14 European countries and Egypt.

Patients:

Prepubertal male and female treatment-naïve children with GHD (n = 53).

Interventions:

Subjects received one of three TransCon GH doses (0.14, 0.21, or 0.30 mg GH/kg/wk) or Genotropin 0.03 mg GH/kg/d for 26 weeks.

Main Outcome Measures:

GH and insulinlike growth factor-1 (IGF-1) levels, growth, adverse events, and immunogenicity.

Results:

Both GH maximum concentration and area under the curve were similar following TransCon GH or Genotropin administration at comparable doses. A dose response was observed, with IGF-1 standard deviation scores increasing into the normal range for all three TransCon GH doses. Annualized mean height velocity for the three TransCon GH doses ranged from 11.9 cm to 13.9 cm, which was not statistically different from 11.6 cm for Genotropin. Adverse events were mild to moderate, and most were unrelated to the study drug. Injection site tolerance was good. One TransCon GH subject developed a low-titer, nonneutralizing antibody response to GH.

Conclusions:

The results suggest that long-acting TransCon GH is comparable to daily Genotropin for GH (pharmacokinetics) and IGF-1 (pharmacodynamics) levels, safety, and efficacy and support advancement into phase 3 development.
Persistent Reduction of Circulating Myeloid Calcifying Cells in Acromegaly: Relevance to the Bone–Vascular Axis
Authors: Fadini Gian Paolo , Dassie Francesca , Cappellari Roberta , Persano Mariasara , Vigili de Kreutzenberg Saula , Martini Chiara , Parolin Matteo , Avogaro Angelo , Vettor Roberto , Maffei Pietro
Published: April 2017

Context:

Acromegaly is a systemic disease characterized by persistent bone pathology and excess cardiovascular mortality. Despite multiple concomitant risk factors, atherosclerosis does not seem to be accelerated in acromegaly.

Objective:

To compare the levels of circulating myeloid calcifying cells (MCCs), which promote ectopic calcification and inhibit angiogenesis, in individuals with and without acromegaly.

Design:

Cross-sectional case-control study.

Setting:

Tertiary ambulatory referral endocrinology center.

Patients:

44 acromegalic patients (25 active; 19 inactive), 44 control subjects matched by age, sex, risk factors, and medications, and 8 patients cured of acromegaly.

Intervention:

MCCs were measured using flow cytometry based on the expression of osteocalcin (OC) and bone alkaline phosphatase (BAP) on monocytes and circulating CD34+ stem cells.

Main Outcome Measure:

Differences in MCCs between patients and controls.

Results:

OC+BAP+ MCCs were severely reduced in acromegalic compared with control patients (0.17% ± 0.02% vs 1.00% ± 0.24%; P < 0.001), as were the total OC+ and BAP+ monocytic cells. Patients with inactive acromegaly and those cured of acromegaly displayed persistently reduced levels of MCCs. In the controls, but not acromegalic patients, MCCs were increased in the presence of diabetes or cardiovascular disease. A direct correlation was noted between MCCs and parathyroid hormone (r = 0.61; P < 0.0001), supporting a link between bone biology and MCCs.

Conclusions:

In patients with acromegaly, the levels of MCCs are reduced and remain low, even years after a complete cure. This finding might be related to low atherosclerotic calcification and the persistence of bone pathology after acromegaly remission or cure.
Corpor(e)al Cartographies of New Materialism
Authors: Rogowska-Stangret Monika
Published: April 2017

This essay sketches cartographies of new materialism with reference to theoretical dynamics and transformations of the category of the body. By tracing interconnections between concepts of corporeality coined by Elizabeth Grosz, transcorporeality developed by Stacy Alaimo, and “viscous porosity” introduced by Nancy Tuana and referring to the philosophical work of Brian Massumi and Erin Manning and also to artistic work by Pinar Yoldas, this article introduces the concept of the body depicted as always gesturing toward what is beyond and more than a body and as intrinsically oriented toward its own “elsewhere.” This reconceptualization of the body proves its ability to “push dualisms to the extreme.”
Assembled Bodies
Authors: Stark Whitney
Published: April 2017

In this semimanifesto, I approach how understandings of quantum physics and cyborgian bodies can (or always already do) ally with feminist anti-oppression practices long in use. The idea of the body (whether biological, social, or of work) is not stagnant, and new materialist feminisms help to recognize how multiple phenomena work together to behave in what can become legible at any given moment as a body. By utilizing the materiality of conceptions about connectivity often thought to be merely theoretical, by taking a critical look at the noncentralized and multiple movements of quantum physics, and by dehierarchizing the necessity of linear bodies through time, it becomes possible to reconfigure structures of value, longevity, and subjectivity in ways explicitly aligned with anti-oppression practices and identity politics. Combining intersectionality and quantum physics can provide for differing perspectives on organizing practices long used by marginalized people, for enabling apparatuses that allow for new possibilities of safer spaces, and for practices of accountability.
Reciprocal proteasome-mediated degradation of PIFs and HFR1 underlies photomorphogenic development in Arabidopsis
Authors: Xu Xiaosa , Kathare Praveen Kumar , Pham Vinh Ngoc , Bu Qingyun , Nguyen Andrew , Huq Enamul
Published: April 2017

The phytochrome-mediated regulation of photomorphogenesis under red and far-red light conditions involves both positively and negatively acting factors. The positively acting factors (e.g. HY5/HFR1/LAF1 and others) are degraded in the dark to prevent photomorphogenesis. By contrast, the negatively acting factors (e.g. phytochrome-interacting factors or PIFs) are degraded in response to light to promote photomorphogenesis. Here, we show that the negatively acting factor PIF1 is also degraded in the dark by direct heterodimerization with the positively acting factor HFR1. Conversely, PIF1 also promotes the degradation of HFR1 in darkness. PIF1 enhances the poly-ubiquitylation of HFR1 by COP1 in vivo and in vitro. In addition, the reciprocal co-degradation of PIF1 and HFR1 is dependent on the 26S proteasome pathway in vivo. Genetic evidence shows that the hfr1 mutant partially suppresses the constitutive photomorphogenic phenotypes of cop1-6 pif1 and of the quadruple mutant pifq both in the dark and in far-red light conditions. Taken together, these data uncover a co-degradation mechanism between PIFs and HFR1 that underlies photomorphogenic development in Arabidopsis thaliana.
Archer fish jumping prey capture: kinematics and hydrodynamics
Authors: Shih Anna M. , Mendelson Leah , Techet Alexandra H.
Published: April 2017

Smallscale archer fish, Toxotes microlepis, are best known for spitting jets of water to capture prey, but also hunt by jumping out of the water to heights of up to 2.5 body lengths. In this study, high-speed imaging and particle image velocimetry were used to characterize the kinematics and hydrodynamics of this jumping behavior. Jumping used a set of kinematics distinct from those of in-water feeding strikes and was segmented into three phases: (1) hovering to sight prey at the surface, (2) rapid upward thrust production and (3) gliding to the prey once out of the water. The number of propulsive tail strokes positively correlated with the height of the bait, as did the peak body velocity observed during a jump. During the gliding stage, the fish traveled ballistically; the kinetic energy when the fish left the water balanced with the change in potential energy from water exit to the maximum jump height. The ballistic estimate of the mechanical energy required to jump was comparable with the estimated mechanical energy requirements of spitting a jet with sufficient momentum to down prey and subsequently pursuing the prey in water. Particle image velocimetry showed that, in addition to the caudal fin, the wakes of the anal, pectoral and dorsal fins were of nontrivial strength, especially at the onset of thrust production. During jump initiation, these fins were used to produce as much vertical acceleration as possible given the spatial constraint of starting directly at the water's surface to aim.
Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish
Authors: Lopez-Luna Javier , Al-Jubouri Qussay , Al-Nuaimy Waleed , Sneddon Lynne U.
Published: April 2017

Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days post-fertilization were exposed to known noxious stimuli: acetic acid (0.01%, 0.1% and 0.25%) and citric acid (0.1%, 1% and 5%). The behavioural response of each was recorded and analysed using novel tracking software that measures time spent active in 25 larvae at one time. Subsequently, the efficacy of aspirin, lidocaine, morphine and flunixin as analgesics after exposure to 0.1% acetic acid was tested. Larvae exposed to 0.1% and 0.25% acetic acid spent less time active, whereas those exposed to 0.01% acetic acid and 0.1–5% citric acid showed an increase in swimming activity. Administration of 2.5 mg l−1 aspirin, 5 mg l−1 lidocaine and 48 mg l−1 morphine prevented the behavioural changes induced by acetic acid. These results suggest that larvae respond to a noxious challenge in a similar way to adult zebrafish and other vertebrates and that the effect of nociception on activity can be ameliorated by using analgesics. Therefore, adopting larval zebrafish could represent a direct replacement of a protected adult fish with a non-protected form in pain- and nociception-related research.
How High Should We Go? Determining Reservation Values to Negotiate Successfully for Composite Software Services
Authors: Sun Sherry X. , Zhao Jing , Sarkar Sumit
Published: April 2017

In the paradigm of service-centric computing, new value-added applications can be developed dynamically and flexibly by combining and integrating existing services. While software applications are traditionally specified and implemented as a set of functions uniform to all users, this new paradigm allows the same software service to be delivered with a different price, response time, availability, and other nonfunctional attributes to accommodate different modes of use. These nonfunctional attributes together are referred to as Quality of Service (QoS). When creating a new composite service, negotiation makes it possible for a service provider to offer the service with the QoS properties customized to the needs of a user. Automated negotiation tactics require the specification of reservation values for the QoS attributes. We present a methodology that determines the reservation values a user (or broker) should use for each component service based on the user’s minimum requirements for the composite service. Our methodology maximizes the chance of reaching a successful negotiation outcome while staying within the user’s reservation values for the composite service. We show that the problem of determining the user’s reservation values for component services can be modeled as a multiobjective optimization problem and then transformed to a single-objective optimization problem using a max-min approach. The formulation can incorporate providers' different QoS preferences to increase the chance of negotiation success. We identify problem instances for which closed-form solutions can be found for the reservation values. We show how the method of setting reservation values can be incorporated into a negotiation process that uses extant concession and trade-off tactics. Simulation experiments demonstrate the effectiveness of the proposed approach. If some providers accept offers before the negotiation process deadline, we show that dynamically changing the reservation values for the remaining providers makes the overall negotiation process more likely to succeed.

The online appendix is available at https://doi.org/10.1287/isre.2016.0678 .
Pharmacy Dashboard: An Innovative Process for Pharmacy Workload and Productivity
Authors: Kinney Ashley , Bui Quyen , Hodding Jane , Le Jennifer
Published: April 2017

Background

Innovative approaches, including LEAN systems and dashboards, to enhance pharmacy production continue to evolve in a cost and safety conscious health care environment. Furthermore, implementing and evaluating the effectiveness of these novel methods continues to be challenging for pharmacies.

Objective

To describe a comprehensive, real-time pharmacy dashboard that incorporated LEAN methodologies and evaluate its utilization in an inpatient Central Intravenous Additives Services (CIVAS) pharmacy.

Methods

Long Beach Memorial Hospital (462 adult beds) and Miller Children's and Women's Hospital of Long Beach (combined 324 beds) are tertiary not-for-profit, community-based hospitals that are served by one CIVAS pharmacy. Metrics to evaluate the effectiveness of CIVAS were developed and implemented on a dashboard in real-time from March 2013 to March 2014.

Results

The metrics that were designed and implemented to evaluate the effectiveness of CIVAS were quality and value, financial resilience, and the department's people and culture. Using a dashboard that integrated these metrics, the accuracy of manufacturing defect-free products was ≥99.9%, indicating excellent quality and value of CIVAS. The metric for financial resilience demonstrated a cost savings of $78,000 annually within pharmacy by eliminating the outsourcing of products. People and value metrics on the dashboard focused on standard work, with an overall 94.6% compliance to the workflow.

Conclusion

A unique dashboard that incorporated metrics to monitor 3 important areas was successfully implemented to improve the effectiveness of CIVAS pharmacy. These metrics helped pharmacy to monitor progress in real-time, allowing attainment of production goals and fostering continuous quality improvement through LEAN work.
Clinical Feasibility of Monitoring Enoxaparin Anti-Xa Concentrations: Are We Getting it Right?
Authors: Kufel Wesley D. , Seabury Robert W. , Darko William , Probst Luke A. , Miller Christopher D.
Published: April 2017

Background

Anti-Xa monitoring is utilized to measure the extent of anticoagulation in certain patient populations receiving enoxaparin. It is essential to accurately obtain this pharmacodynamic marker for safe and effective anticoagulation management.

Objectives

To determine the frequency of correctly drawn anti-Xa concentrations in accordance with predefined institutional criteria and to determine the number of dose adjustments implemented based on incorrectly drawn anti-Xa concentrations.

Methods

This was a retrospective, single-center, cohort study among adult patients who received treatment doses of enoxaparin with measured anti-Xa concentrations. Patients were excluded if they were pregnant, on hemodialysis, or received prophylactic dosing. Anti-Xa levels were defined as correctly measured if they were drawn 3 to 5 hours after the dose during steady state concentrations. Descriptive statistics were performed and analyzed via SPSS software.

Results

Overall, 203 patients were reviewed and 59 patients with 74 anti-Xa levels were included. The majority of anti-Xa levels (57/74; 77%) were drawn incorrectly and often resulted in collection of repeat anti-Xa samples. There were 12 documented dose adjustments and approximately 42% (5/12) were based on incorrectly drawn anti-Xa levels. Anti-Xa levels were within target range approximately 45% of the time.

Conclusions

Enoxaparin anti-Xa concentrations are frequently drawn incorrectly and dose adjustments are often performed based on these unsupported anti-Xa levels. This may present a potential risk to compromise patient safety.
Anne Carson’s Nox: Materiality and memory
Authors: Rapatzikou Tatiani G.
Published: April 2017

This article focuses on Anne Carson’s Nox, a boxed book published in 2010. What makes it special is the physicality of its format as well as its multi-layered and polymorphous text that due to its fold-out construction invites readers to investigate the missing words and phrases, or the spaces left between its pasted documents so as to confront the experiences narrated and shared through them. This article discusses how Nox’s design allows an examination of the means by which stories can be told and traumatic events can be treated. In this way, the physicality of Carson’s Nox both preserves and enhances the memory of the personal experience it attempts to communicate, due to the various spatial arrangements it proposes of its verbal and visual materials.
To Tenant: Situating the Realtor Within
Authors: Fleet Darren
Published: April 2017

Under the guise of national and international capital flows, Vancouverites are reconstituted in the image of real estate speculation. This emerging subjectivity is a lens through which homelessness is criminalized, poverty is rationalized, and disruption is fetishized. This photo-essay steps into this gaze, offering a critical perspective on the transformation of housing from a discourse of rights to the language of finance.
Visibilities of Exchange Across Forms: A Case Study of The House Of Mirth
Authors: Rangwala Shama
Published: April 2017

This comparative reading of Edith Wharton’s The House of Mirth (1905) and Terence Davies’ film adaptation (2000) examines how different media make visible inequities of exchange and belie ideals of collectivity and democracy.
Border, Theory, Contract: An Interview with Angela Mitropoulos
Authors: O’Brien Sean
Published: April 2017

This interview with Angela Mitropoulos explores contemporary questions of migration, border control, financial speculation, critical theory and political practice. Mitropoulos is a political theorist, academic and activist based in Sydney, Australia, whose work has examined shifts to post-Fordism and neoliberalism through a critical history of the contract and in relation to the shifting politics of the household. The interview also addresses her recent work, in her capacities as both an academic and an activist, which continues to confront the complex and evolving relationships between political economy, border control, and critical theory.
Design and Realization of FIR Filter for Inter Satellite Link at 50-90 MHZ Frequency using FPGA
Authors: Wahyu Yuyu , Paramayudha Ken , Jamil Setiawan Lutfi , Wijanto Heroe , Shiddiq S.H M.
Published: April 2017

In this paper, design and realization of FIR filter with a bandwidth of 40 MHz at 50-90 MHz frequency has been proposed. The design was destined to be implemented on the Inter Satellite Links (ISL). This kind of filter had been selected due to a need in linear phase responseon the ISL data communication. Equiripple method was used to design the filter becauseof its reliability in minimizing the magnitude errors. The design of this FIR filter was conducted with theoretical calculation and simulation using the R2012b Matlab. For the implementation, FPGA was used with a VHDL as the programming language with a help of Xilinx ISE Design Suite 14.5. Simulation results in Matlab and Simulink indicated that the filter design could be well implemented on ISL at frequency of 50 MHz - 90 MHz with stopband of 60 db. The phase responseresult of the realized design is quite linear so that the filter is suitable for data communication on the ISL.
Sistem Monitoring Online Kualitas Air Akuakultur untuk Tambak Udang Menggunakan Aplikasi Berbasis Android
Authors: Kusrini Priyani , Wiranto Goib , Syamsu Iqbal , Hasanah Lilik
Published: April 2017

Pemantauan kualitas air di tambak udang yang efektif sangat dibutuhkan agar produksi udang meningkat. Oleh karena itu, pada penelitian ini telah dibuat aplikasi sistem online monitoring kualitas air tambak udang berbasis android. Pengambilan data parameter sensor dilakukan di kampus LIPI menggunakan stasiun sensor yang datanya ditransmisikan ke data logger untuk selanjutnya dikirimkan ke website. Data yang diperoleh dari website berupa data php (Hyper Text Preprocessor) dan kemudian diubah menjadi data JSON (Java Script Object Notation). Parsing data dilakukan dengan menggunakan fungsi json_encode untuk membuat string JSON dari objek dan array sehingga data dapat dibaca di Android Studio. Aplikasi ini sangat mudah dioperasikan dan sangat efisien.
Existence and regularity results for weak solutions to (p,q)-elliptic systems in divergence form
Authors: Bulíček Miroslav , Cupini Giovanni , Stroffolini Bianca , Verde Anna
Published: April 2017

We prove existence and regularity results for weak solutions of non-linear elliptic systems with non-variational structure satisfying

(
p
,
q
)

{(p,q)}

-growth conditions. In particular, we are able to prove higher differentiability results under a dimension-free gap between p and q.
On a new class of fractional partial differential equations II
Authors: Shieh Tien-Tsan , Spector Daniel E.
Published: April 2017

In this paper we continue to advance the theory regarding the Riesz fractional gradient in the calculus of variations and fractional partial differential equations begun in an earlier work of the same name. In particular, we here establish an

L
1

{L^{1}}

Hardy inequality, obtain further regularity results for solutions of certain fractional PDE, demonstrate the existence of minimizers for integral functionals of the fractional gradient with non-linear dependence in the field, and also establish the existence of solutions to corresponding Euler–Lagrange equations obtained as conditions of minimality. In addition, we pose a number of open problems, the answers to which would fill in some gaps in the theory as well as to establish connections with more classical areas of study, including interpolation and the theory of Dirichlet forms.
Diffusive logistic equations with harvesting and heterogeneity under strong growth rate
Authors: Shabani Rokn-e-vafa Saeed , Tehrani Hossein T.
Published: April 2017

We consider the equation

-\Delta u=au-b(x)u^{2}-ch(x)\quad\text{in }\Omega,\qquad u=0\quad\text{on }%
\partial\Omega,

where Ω is a smooth bounded domain in

{\mathbb{R}^{N}}

,

{b(x)}

and

{h(x)}

are nonnegative functions, and there exists

{\Omega_{0}\subset\subset\Omega}

such that

{\{x:b(x)=0\}=\overline{\Omega}_{0}}

.
We investigate the existence of positive solutions of this equation for c large under the strong growth rate assumption

{a\geq\lambda_{1}(\Omega_{0})}

, where

{\lambda_{1}(\Omega_{0})}

is the first eigenvalue of the

{-\Delta}

in

{\Omega_{0}}

with Dirichlet boundary condition.
We show that if

{h\equiv 0}

in

{\Omega\setminus\overline{\Omega}_{0}}

, then our equation has a unique positive solution for all c large, provided that a is in a right neighborhood of

{\lambda_{1}(\Omega_{0})}

.
For this purpose, we prove and utilize some new results on the positive solution set of this equation in the weak growth rate case.
Existence and concentration behavior of solutions for a class of quasilinear elliptic equations with critical growth
Authors: Teng Kaimin , Yang Xiaofeng
Published: April 2017

In this paper, we study a class of quasilinear elliptic equations involving the Sobolev critical exponent

-\varepsilon^{p}\Delta_{p}u-\varepsilon^{p}\Delta_{p}(u^{2})u+V(x)\lvert u%
\rvert^{p-2}u=h(u)+\lvert u\rvert^{2p^{*}-2}u\quad\text{in }\mathbb{R}^{N},

where

{\Delta_{p}u=\operatorname{div}(\lvert\nabla u\rvert^{p-2}\nabla u)}

is the p-Laplace operator,

{p^{*}=\frac{Np}{N-p}}

(

{N\geq 3}

,

{N>p\geq 2}

) is the usual Sobolev critical exponent, the potential

{V(x)}

is a continuous function, and the nonlinearity

{h(u)}

is a nonnegative function of

{C^{1}}

class. Under some suitable assumptions on V and h, we establish the existence, multiplicity and concentration behavior of solutions by using combing variational methods and the theory of the Ljusternik–Schnirelman category.
Amazonisierung der Industriearbeit?
Authors: Butollo Florian , Ehrlich Martin , Engel Thomas
Published: April 2017

Industrie 4.0 wird in der öffentlichen Diskussion meist im Sinne einer disruptiven Veranderung thematisiert. Unsere Fallstudie bei einem Montagewerk der Automobilindustrie, in dem wir Elemente der Industrie 4.0 verwirklicht sehen, offenbart hingegen starke Kontinuitäten zu vorangegangenen Paradigmen industrieller Organisation wie dem Lean-Production-Prinzip bzw. seiner Fortführung zu so genannten Build-to-order-Konzepten (BTO), die auf eine intelligente Verknüpfung von Kunden, Unternehmen und Zulieferern abstellen. Im untersuchten Werk impliziert das einen deutlichen Bedeutungszuwachs der Intralogistik, verbunden mit einem entsprechenden Beschäftigungsaufbau. Mit diesen Verschiebungen verändert sich auch der Charakter industrieller Arbeit. Neben der Montagetätigkeit und Maschinenführung entstehen neue Anforderungsprofile, die auf niedrigen Qualifikationen und schneller Einarbeitung beruhen. Das Szenario eines Nexus von individualisierter Produktion, Ablaufdeterminismus und einem Beschäftigungszuwachs in eher gering-qualifizierten Tätigkeiten der Intralogistik bezeichnen wir aufgrund struktureller Ähnlichkeiten zur Branche des Online-Handels als „Amazonisierung der Industriearbeit“.
Genetic diversity and biogeography in Chaetomorpha melagonium (Ulvophyceae, Cladophorales) based on internal transcribed spacer (ITS rDNA) sequences
Authors: Boedeker Christian , Leliaert Frederik , Zuccarello Giuseppe C.
Published: April 2017

is a morphologically distinct species of green algae that occurs throughout the North Atlantic, the North Pacific and the Arctic Ocean. In this study, we analyzed the intraspecific genetic diversity among 14 samples of
A numerical model to assess the role of crack-tip hydrostatic stress and plastic deformation in environmental-assisted fatigue cracking
Authors: Baragetti Sergio , Villa Francesco
Published: April 2017

To better understand the mechanics of environmentally assisted cracking, and particularly hydrogen embrittlement, a correct description of the hydrostatic stress field is indispensable. The concentration of hydrogen in the proximity of the crack tip is indeed dependent of the hydrostatic stress effect on the microstructural lattice of the material. The overall parameters of the hydrostatic stress, including peak value, its location, gradient, and distribution size are fundamental to assess the effect on hydrogen distribution near the crack tip, specifically considering hydrogen-enhanced decohesion mechanism, or the HEDE mechanism. Hydrostatic stress is hence widely analysed in studies related to hydrogen embrittlement contribution in stress corrosion cracking or corrosion fatigue of metallic alloys. However, recent studies highlighted that the hydrogen-enhanced local plasticity (HELP) mechanism can be more relevant than HEDE in hydrogen-assisted fatigue failure of metallic alloys. In order to investigate the contribution of the HELP mechanism, detailed finite element modelling is reported for notched Ti-6Al-4V specimens, based on experimental fatigue data. The material is modelled with elastic-perfectly plastic behaviour, reproducing actual geometry of the notches and the fatigue crack, from measurements and replicas conducted during testing. Strain data are obtained in initial and final crack configuration, to discuss the HELP contribution on environmentally assisted cracking, and compare it with HEDE contribution linked to hydrostatic stress.
Electron Beam Misalignment Study of MIG for 42 GHz, 200 kW Gyrotron
Authors: Sharma S. K , Singh Udaybir , Kumar Nitin , Sahu Naveen , Shekhawat Narendra , Srivastava Deepak , Alaria M.K , Bera A , Jain P. K , Sinha A. K
Published: April 2017

This paper presents the electron beam misalignment study with respect to cathode position and cathode magnetic field of 42 GHz, 200 kW gyrotron. The performance of gyrotron is affected with the misalignment of cathode position. The simulation results confirm the tolerance of cathode misalignment with respect to the design parameters such as the transverse-to-axial velocity ratio, the maximum transverse velocity spread, etc.
Pseudo-free families of finite computational elementary abelian p-groups
Authors: Anokhin Mikhail
Published: April 2017

We initiate the study of (weakly) pseudo-free families of computational elementary abelian
Public-key cryptosystem based on invariants of diagonalizable groups
Authors: Marko František , Zubkov Alexandr N. , Juráš Martin
Published: April 2017

We develop a public-key cryptosystem based on invariants of diagonalizable groups and investigate properties of such a cryptosystem first over finite fields, then over number fields and finally over finite rings. We consider the security of these cryptosystem and show that it is necessary to restrict the set of parameters of the system to prevent various attacks (including linear algebra attacks and attacks based on the Euclidean algorithm).
Enzymatic grafting of kraft lignin as a wood bio-protection strategy. Part 2: effectiveness against wood destroying basidiomycetes. Effect of copper entrapment
Authors: Fernández-Costas Carmen , Palanti Sabrina , Sanromán María Ángeles , Moldes Diego
Published: April 2017

Enzymatic grafting of kraft lignin (KL) on wood surfaces is presented as a non-leachable wood protection treatment. Scots pine and European beech mini-blocks were treated with KL solution in the presence of laccase isolated from Myceliophthora thermophila and the formation of a stable interaction between wood and lignin was observed. Furthermore, the same strategy was employed to graft KL with the simultaneous entrapment of copper in the polymeric net formed. Enzymatic treatment diminished the leachability of the compounds in accordance with the EN 84 standard. The durability of the leached wood blocks was evaluated by accelerated decay tests. Samples with grafted lignin on the surface lost their antifungal activity in long-term exposure at the concentration tested. This observation is in contradiction to the preliminary tests, where KL seemed to have some biocidal activity. On the other hand, KL grafting in combination with copper entrapment improved the decay resistance and the copper leaching was reduced.
From Eco’s Aperturato Fractal Narrative: Recursion as a Tool of Order in Contemporary Narratives
Authors: Duarte German A.
Published: April 2017

In 1962 Umberto Eco published his Opera aperta. Forma e indeterminazione nelle poetiche contemporanee, in which he dealt with the televised space and its influence on the development of plot in contemporary narratives. The analysis of the aesthetic of television led him to highlight the exclusive capacity of television to transmit events in real time: Live TV.Eco affirms in particular that through the editing in Live TV, the role of choice completely changes in comparison to what happens in the editing phase within the cinematographic narrative. In Live TV, choice becomes a proper composition, a form of narrative, a means of unifying in a discursive way a set of isolated images within the framework of a wider set of events taking place at the same time and intersecting one another. This impromptu narrative brings with it the use of some recursive forms, which represent an important narrative tool enabling a weaving of the narrative space. Eco identified those recursive forms in some jazz figures such as the riff, the recursive form of which allows for the creation of an organic composition full of improvisation. A few years later, the importance of figures of this kind was also noted by Deleuze-Guattari (1980), who posited that ritornello has an important function of organizing the exterior space, or chaotic space. Based on these considerations, this paper deals with the phenomenon of repetition, recursivity, and patterns, to bring these concepts into the construction of narrative spaces. The central point of the paper is that the birth of Live TV started a phenomenon of exteriorization of the inner data of the narrative construction. This phenomenon of externalization makes possible the understanding of data through spatial terms, and one starts to use recursive formulas to navigate it.
Integration and visualization of spatial data in LIFE
Authors: Lin Ying-Chi , Groß Anika , Kirsten Toralf
Published: April 2017

It is usually a challenging task to integrate and analyze huge amounts of heterogeneous data in large medical research
projects. Often meaningful new insights can be achieved by visualizing medical data on geographical maps. For instance in
epidemiological studies, data is often explored on a spatial dimension. LIFE is a large epidemiological study, managed by
the LIFE Research Center for Civilization Diseases at Leipzig University. The study investigates the health-related states
of the local population, e.g. by looking at the role of lifestyle factors on major civilization diseases. To allow for an
effective data exploration, the development of sophisticated data analysis and spatial visualization techniques is
necessary. Here, we present the interactive web application LIFE Spatial Data Visualization System (LIFE-SDVS)
that adds a geographical facet to the data integration and analysis workflow of the LIFE research project.
Degradation of imidacloprid insecticide in a binary mixture with propylene glycol by conventional fenton process
Authors: de Luna Mark Daniel G. , Retumban Joseph D , Garcia-Segura Sergi , Lu Ming-Chun
Published: April 2017

Imidacloprid is one of the most widely used insecticides in agriculture. The fate of this highly recalcitrant pollutant and its by-product of incomplete degradation in water is of great concern due to the hazardous effects usually associated to pesticides. In the present manuscript, imidacloprid degradation by hydroxyl radical produced
Policies for Happiness in the Global Village
Authors: Dima Bogdan , Dima Ştefana Maria
Published: April 2017

This article employs three different measures of life satisfaction viewed as proxy for social utility, in order to test for the possible non-linear interactions between the quality of public governance, as reflected by the World Bank indicators, and globalization, as captured by the KOF index, for a dataset of 99 countries for a time span between 2001 and 2010. We conclude that efficient and trustworthy public policies may enhance life satisfaction. Moreover, there may occur a synergy effect between ‘good’ governance and globalization (especially for those components describing social globalization), while there is no substitute for the failure of public policies, in terms of human development and growth (with the effects on human development being substantially more important than those corresponding to the increase in national wealth).
Adaptive Gearbox Selection Method to Improve the Performance of Industrial Robotic Arms
Authors: Hayat Mohammad Athar , Mankar Ankush A.
Published: April 2017

Robotic arms play a major role in today’s environment. Many robotic arms are used in industries, factories, and our surrounding environments. Many types of robotic arms are used for their particular purpose. Gearbox selection is very important in increasing the performance of robotic arms. Therefore, it is necessary to select the gearbox to improve the performance of robotic arms for everyday use. Thus, an efficient method is proposed to improve the performance of robotic arms for industries. This efficient method adaptively controls the gearbox to increase the performance of industrial robotic arms. The cuckoo search algorithm is an efficient method proposed to increase the performance of industrial robotic arms. By this method, we can improve the performance of industrial robotic arms and make use of these robotic arms in the modern world. The technique has been implemented in the working platform of MATLAB, and the results have been analyzed.
Multiple differential-zero correlation linear cryptanalysis of reduced-round CAST-256
Authors: Hadian Dehkordi Massoud , Taghizadeh Roghayeh
Published: April 2017

CAST-256 (or CAST6) is a symmetric-key block cipher published in June 1998.
It was submitted as a candidate for Advanced Encryption Standard (AES). In
this paper, we will propose a new chosen text attack, the multiple
differential-zero correlation linear attack, to analyze the CAST-256 block
cipher. Our attack is the best-known attack on CAST-256 according to the
number of rounds without the weak-key assumption. We first construct a
30-round differential-zero correlation linear distinguisher. Based on the
distinguisher, we propose a first 33-round attack on CAST-256 with data
complexity of

2
115.63

{2^{115.63}}

and time complexity

2
238.26

{2^{238.26}}

. In the end, the
111-bit subkey is recovering.
3-D near-field imaging of guided modes in nanophotonic waveguides
Authors: Ziegler Jed I. , Pruessner Marcel W. , Simpkins Blake S. , Kozak Dmitry A. , Park Doewon , Fatemi Fredrik K. , Stievater Todd H.
Published: April 2017

Highly evanescent waveguides with a subwavelength core thickness present a promising lab-on-chip solution for generating nanovolume trapping sites using overlapping evanescent fields. In this work, we experimentally studied Si3N4 waveguides whose sub-wavelength cross-sections and high aspect ratios support fundamental and higher order modes at a single excitation wavelength. Due to differing modal effective indices, these co-propagating modes interfere and generate beating patterns with significant evanescent field intensity. Using near-field scanning optical microscopy (NSOM), we map the structure of these beating modes in three dimensions. Our results demonstrate the potential of NSOM to optimize waveguide design for complex field trapping devices. By reducing the in-plane width, the population of competing modes decreases, resulting in a simplified spectrum of beating modes, such that waveguides with a width of 650 nm support three modes with two observed beats. Our results demonstrate the potential of NSOM to optimize waveguide design for complex field trapping devices.
Synthesis and crystal structure of 2-((5-chlorobenzo[c][1,2,5]thiadiazol-4-yl)amino)-4,5-dihydro-1H-imidazol-3-ium tetraphenylborate, C33H29BClN5S
Authors: Ghabbour Hazem A. , Mostafa Gamal A.E.
Published: April 2017

C33H29BClN5S, monoclinic, P21/c, a = 11.2163(7) Å, b = 15.2998(10) Å, c = 19.5929(11) Å, β = 122.251(3)°, V = 2843.5(3) Å3, Z = 4, R
gt(F) = 0.0592, wR
ref(F
2) = 0.1362, T = 293 K.
Crystal structure of 3-amino-8-methoxy-1-phenyl-1H-benzo[f]chromene-2-carbonitrile, C21H16N2O2
Authors: Okasha Rawda M. , Amr Abd El-Galil E. , El-Agrody Ahmed M. , Al-Omar Mohamed A. , Ghabbour Hazem A.
Published: April 2017

C21H16N2O2, triclinic, P1̅ (no. 2), a = 8.5971(3) Å, b = 9.8586(3) Å, c = 10.6199(4) Å, α = 95.747(2)°, β = 104.384(2)°, γ = 101.768(2)°, V = 842.69(5) Å3, Z = 2, R
gt(F) = 0.0482, wR
ref(F
2) = 0.1377, T = 293(2).
Crystal structure of 1-(3-((5-bromo-2-hydroxybenzylidene)amino)phenyl)ethanone O-benzyl oxime, C22H19BrN2O2
Authors: Wang Yan-Bin
Published: April 2017

C22H19BrN2O2, monoclinic, P21/c (no. 14), a = 18.4760(16) Å, b = 4.8400(3) Å, c = 21.6410(18) Å, b = 96.162(1)°, V = 1924.0(3) Å3, Z = 4, R
gt(F) = 0.0542, wR
ref(F
2) = 0.1719, T = 298(2) K.
Assessment of the correlations between gait speed in post-stroke patients and the time from stroke onset, the level of motor control in the paretic lower limb, proprioception, visual field impairment and functional independence
Authors: Drużbicki Mariusz , Przysada Grzegorz , Podgórska-Bednarz Justyna , Kwolek Andrzej , Pop Teresa , Wyszyńska Justyna , Leszczak Justyna
Published: April 2017

Introduction: Gait recovery is one of the main objectives in the rehabilitation of post-stroke patients. The study aim was to assess the correlations between gait speed in post-stroke hemiparetic patients and the level of motor control in the paretic lower limb, the time from stroke onset, the subjects’ age as well as the impairment of proprioception and visual field.

Materials and methods: This retrospective study was performed at the Clinical Rehabilitation Ward of the Regional Hospital No. 2 in Rzeszow. The study group consisted of 600 patients after a first stroke who walked independently. The measurements focused on gait speed assessed in a 10-meter walking test, motor control in the lower limb according to Brunnström recovery stages, proprioception in lower limbs, visual field as well as functional independence according to The Barthel Index.

Results: The study revealed a slight negative correlation between gait speed and the subjects’ age (r = − 0.25). No correlation was found between mean gait speed and the time from stroke onset. On the other hand, gait speed strongly correlated both with the level of motor control in the lower limb (p = 0.0008) and the incidence of impaired proprioception. Additionally, a strong statistically significant correlation between the patients’ gait speed and the level of functional independence was found with the use of The Barthel Index.

Conclusions: The level of motor control in the paretic lower limb and proprioception are vital factors affecting gait speed and functional independence. Patients with a higher level of functional independence demonstrated higher gait speed.