bluuebunny/crossref_metadata_2025 huggingface dataset:
Work Stress, Health Status and Presenteeism in Relation to Task Performance Among Chinese Medical Staff During COVID-19 Pandemic
Authors: Jia Huanhuan , Shang Panpan , Gao Shang , Cao Peng , Yu Jianxing , Yu Xihe
Published: April 2022

Objectives

This study aims to evaluate the direct effects of work stress, health status and presenteeism on task performance, and further explore the mediating effects of health status and presenteeism, hoping to provide theoretical basis for improving the performance of medical staff.

Methods

A cross-sectional study was conducted among medical staff in Jilin Province, Northeast China. The Challenge and Hindrance-Related Self-Reported Stress scale, Short Form-8 Health Survey scale, Stanford Presenteeism Scale and Task Performance Scale were adopted to assess the work stress, health status, presenteeism and task performance of medical staff.

Results

A total of 4,347 questionnaires were distributed among medical staff, and 4261 were valid, for an effective rate of 98.02%. The mean scores for work stress, health status, presenteeism and task performance were 2.05 ± 0.84, 4.18 ± 0.68, 2.15 ± 0.79 and 4.49 ± 0.64, respectively. The ANOVA results showed that there were significant differences in the task performance scores between different genders, ages, marital statuses, professional titles, departments and work years (P < 0.05). Work stress (β = −0.136, P < 0.001) and presenteeism (β = −0.171, P < 0.001) were negative predictors of task performance. Health status (β = 0.10; P < 0.001) was positive predictor of task performance. Health status (β = −0.070; P < −0.001) and presenteeism (β = −0.064; P < 0.001) mediated the relationship between work stress and task performance (P < 0.001). Presenteeism mediated the relationship between health status and task performance (β = 0.07; P < 0.001).

Conclusion

Work stress and presenteeism had significant negative impact on the task performance of medical staff; health status had a significant positive effect on task performance. Meanwhile, health status and presenteeism played a mediating role in the relationship between work stress and task performance, and presenteeism played a mediating role in the relationship between health status and task performance. Reasonable assignment of tasks can reduce the work stress, but to improve the performance of medical staff, we should pay more attention on improving health, such as making health-related safeguard measures, raising awareness, building a platform, etc.
The Feasibility of a Web-Based Educational Lifestyle Program for People With Multiple Sclerosis: A Randomized Controlled Trial
Authors: Bevens William , Weiland Tracey J. , Gray Kathleen , Neate Sandra L. , Nag Nupur , Simpson-Yap Steve , Reece Jeanette , Yu Maggie , Jelinek George A.
Published: April 2022

Background

Modifiable lifestyle factors are important to aid people with multiple sclerosis in the self-management of their disease. Current self-management programs are limited by their face-to-face mode of delivery but there is immense potential with the internet to deliver these programs effectively.

Objective

The aims of this study are to assess the feasibility of a digitalized educational lifestyle self-management program for people with MS.

Methods

In this randomized controlled trial, people with MS were randomly allocated to participate in a 6-week tailored web-based educational lifestyle program or 6-week generic standard-care educational course, and were blinded to their allocation. Participants were recruited through multiple sclerosis (MS) Societies in four countries: Australia, New Zealand, Canada, and the United States. The primary outcome was to assess acceptability of the program defined as percentage completion of all modules at 6-weeks post-course commencement. Secondary outcomes included evaluating participant responses to the follow-up survey across three domains: accessibility, learnability, and desirability.

Results

Thirty-five participants from Australia, Canada, New Zealand, and the US completed the baseline survey and were randomized. Four participants were deemed ineligible due to incomplete baseline data; therefore, nine out of 15 and eight out of 16 participants completed 100% of the course in the intervention and standard-care arm courses, respectively.

Conclusions

This study found that this web-based educational lifestyle program is a feasible means of delivering educational content to people with MS via the internet according to our a priori targets of >40% of participants in the intervention arm, and >25% in the control arm to completing 100% of the course. It is therefore appropriate to evaluate this intervention further in a large, randomized controlled trial.

Trial registration

This study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ID: ACTRN12621000245897).
Secondary Distribution of HIV Self-Testing Kits to Social and Sexual Networks of PLWH in KwaZulu-Natal, South Africa. A Brief Report
Authors: Sithole Nsika , Koole Olivier , Sausi Kombi , Krows Meighan , Schaafsma Torin , Van Heerden Alastair , Shahmanesh Maryam , van Rooyen Heidi , Celum Connie , Barnabas Ruanne V. , Shapiro Adrienne E.
Published: April 2022

Background

To reach 95% of persons living with HIV (PLWH) knowing their HIV status, alternative testing approaches such as HIV self-testing (HIVST) and secondary HIVST kit distribution are needed. We investigated if secondary HIVST kit distribution from male and female PLWH in South Africa would successfully lead to their contacts testing for HIV and linking to care if positive.

Methods

Male and female PLWH participating in an HIV treatment trial between July and November 2018 in KwaZulu-Natal, South Africa were offered participation as “HIVST kit distributors” in a pilot of secondary distribution of HIVST kits to give to sexual partners and social networks. Univariate descriptive statistics were used to describe the characteristics of volunteer distributors, proportion of HIVST recipients who reported their results, and linkage to care among those who tested positive using HIVST were assessed.

Results

Sixty-three participant kit distributors accepted kits to disperse to contacts, of whom 52% were female, median age was 34 years (IQR 26-42.5), 84% reported 1 sexual partner and 76% did not know their partner's HIV status. HIVST kit distributors took 218 kits, with 13/218 (6%) of kits reported to be intended to be given to a sexual partner. A total of 143 HIVST recipients reported their HIVST results; 92% reported their results were negative, 11 recipients reported positive results and 1 HIVST-positive recipient was linked to HIV care.

Conclusion

Secondary distribution of HIVST to social networks and sexual partners from South African PLWH is feasible, with two thirds of contacts reporting use of the HIVST kits. Additional support is necessary to facilitate linkage to care.
The Relationship Between Health Changes and Community Health Screening Participation Among Older People
Authors: Du Benfeng , Mu Yuexuan
Published: April 2022

The utilization of health screening and other community health services has been a hot topic in China. Thus, this study examined the effect of health changes (self-rated health, physical health, and mental health) on older people's community health screening participation in China. We derived the data from the 2016 and 2018 waves of the Chinese Longitudinal Aging Social Survey (CLASS). This paper included 10,992 observations in two waves. We tested the causal relationship using the fixed effects model. Approximately 29.56% of the respondents participated in a health screening. Notably, after controlling for covariates, changes in mental and physical health both significantly influenced seniors' participation in health screenings (self-rated health: β = 0.188, 95% CI [−0.037, −0.413]; physical health: β = 0.078, 95% CI [0.032, −0.124]; mental health: β = 0.034, 95% CI [−0.057, −0.002]). The findings showed age, educational level, income level, and family support to be significant factors associated with community health screening participation. Additionally, we identified a partial mediating effect of mental health between self-rated health and health screening participation and a partial mediating effect of depression between physical health and health screening participation. The results highlight the important role of health changes in influencing participation and promoting health screening in China. On this basis, healthcare providers in the community may consider health changes as a screening criterion to promote health screening, guiding other health promotion and prevention programs while promoting healthy aging.
Associations Between Wearing Masks and Respiratory Viral Infections: A Meta-Analysis and Systematic Review
Authors: Chen Yiming , Wang Yuelin , Quan Ningbin , Yang Jun , Wu Yinyin
Published: April 2022

Background

Respiratory viral infections (RVIs) are a major health concern, and some previous studies have shown that wearing masks was effective in preventing RVIs, while others failed to show such effect. Therefore, a systematic review and meta-analysis was conducted to investigate the effectiveness of wearing masks.

Methods

PubMed, ScienceDirect, Web of Science, the Cochrane Library, EMBASE, MEDLINE, China National Knowledge Infrastructure (CNKI), and Chinese Scientific Journal Database (VIP database) were searched for studies evaluating the effectiveness of wearing masks. The risk ratio (RR) was used to measure the effectiveness of wearing masks in preventing RVIs for randomized controlled trials (RCTs) and cohort studies, and the odds ratio (OR) was used for case-control studies. Forest plots were used to visually assess pooled estimates and corresponding 95% CIs. TheI2test was used to examine the heterogeneity, and subgroup analysis was used to explore the possible explanations for heterogeneity or compare the results between subgroups. Sensitivity analysis was conducted to assess robustness of the synthesized results. Begg's test and Egger's test were used to assess the publications bias.

Results

Thirty-one studies (13,329 participants) were eligible for meta-analyses. Overall, the results showed that wearing masks was effective in preventing RVIs. The sensitivity analysis showed that the results of those meta-analyses were robust and reliable. There was no significant publication bias in meta-analysis of case-control studies and most subgroup analyses.

Conclusions

Wearing masks might be effective in preventing RVIs. To reduce their RVI risk, people should wear masks when they go out in public.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021296092.
Evaluation of the Therapeutic Effect of Antibiotics on Scrub Typhus: A Systematic Review and Network Meta-Analysis
Authors: Lu Dafeng , Wang Taiwu , Luo Zhenghan , Ye Fuqiang , Qian Jiaojiao , Zhang Jinhai , Wang Chunhui
Published: April 2022

Background

To explore the efficacy and safety of drugs in patients with scrub typhus.

Methods

For this systematic review and network meta-analysis, we searched PubMed, Embase, Web of Science, Cochrane Central Register of Clinical Trials, China National Knowledge Infrastructure (CNKI), and Wanfang data (WF) up to December 2021. All randomized controlled trials (RCTs) of antibiotics used to treat scrub typhus were included without language or date restrictions. The overall effectiveness was evaluated from 4 perspectives: cure rate (CR), defervescence time (DT), gastrointestinal symptoms–adverse events (GS-AD), and abnormal blood count–adverse events (ABC-AD). The quality of evidence was evaluated using the Cochrane Risk of Bias tool and GRADE system.

Results

Sixteen studies involving 1,582 patients were included to evaluate 7 drugs, namely, azithromycin, doxycycline, chloramphenicol, tetracycline, rifampin, moxifloxacin, and telithromycin. In this network meta-analysis, rifampicin (82%) and chloramphenicol (65%) were more effective in terms of CR, and moxifloxacin (3%) from the quinolone family was the worst. Azithromycin caused the fewest events in terms of ABC-AD. No differences were found in this network meta-analysis (NMA) in terms of DT and GS-AD.

Conclusions

Rifampicin was associated with the highest CR benefit and the lowest risk of DT when used to treat patients with scrub typhus, except in areas where tuberculosis (TB) was endemic. Azithromycin was found to be better in CR and was associated with a lower probability of GS-AD and ABC-AD; therefore, it may be considered to treat pregnant women and children. Moxifloxacin had a much lower CR than other drugs and is, therefore, not recommended for the management of scrub typhus.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021287837.
The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response in C. elegans
Authors: Barrett Lindsey N. , Westerheide Sandy D.
Published: April 2022

The decline of proteostasis is a hallmark of aging that is, in part, affected by the dysregulation of the heat shock response (HSR), a highly conserved cellular response to proteotoxic stress in the cell. The heat shock transcription factor HSF-1 is well-studied as a key regulator of proteostasis, but mechanisms that could be used to modulate HSF-1 function to enhance proteostasis during aging are largely unknown. In this study, we examined lysine acetyltransferase regulation of the HSR and HSF-1 in C. elegans. We performed an RNA interference screen of lysine acetyltransferases and examined mRNA expression of the heat-shock inducible gene hsp-16.2, a widely used marker for HSR activation. From this screen, we identified one acetyltransferase, CBP-1, the C. elegans homolog of mammalian CREB-binding protein CBP/p300, as a negative regulator of the HSR. We found that while knockdown of CBP-1 decreases the overall lifespan of the worm, it also enhances heat shock protein production upon heat shock and increases thermotolerance of the worm in an HSF-1 dependent manner. Similarly, we examined a hallmark of HSF-1 activation, the formation of nuclear stress bodies (nSBs). In analyzing the recovery rate of nSBs, we found that knockdown of CBP-1 enhanced the recovery and resolution of nSBs after stress. Collectively, our studies demonstrate a role of CBP-1 as a negative regulator of HSF-1 activity and its physiological effects at the organismal level upon stress.
Location and Language Independent Fake Rumor Detection Through Epidemiological and Structural Graph Analysis of Social Connections
Authors: Serpanos Dimitrios , Xenos Georgios , Tsouvalas Billy
Published: April 2022

Detection and identification of misinformation and fake news is a complex problem that intersects several disciplines, ranging from sociology to computer science and mathematics. In this work, we focus on social media analyzing characteristics that are independent of the text language (language-independent) and social context (location-independent) and common to most social media, not only Twitter as mostly analyzed in the literature. Specifically, we analyze temporal and structural characteristics of information flow in the social networks and we evaluate the importance and effect of two different types of features in the detection process of fake rumors. Specifically, we extract epidemiological features exploiting epidemiological models for spreading false rumors; furthermore, we extract graph-based features from the graph structure of the information cascade of the social graph. Using these features, we evaluate them for fake rumor detection with 3 configurations: (i) using only epidemiological features, (ii) using only graph-based features, and (iii) using the combination of epidemiological and graph-based features. Evaluation is performed with a Gradient Boosting classifier on two benchmark fake rumor detection datasets. Our results demonstrate that epidemiological models fit rumor propagation well, while graph-based features lead to more effective classification of rumors; the combination of epidemiological and graph-based features leads to improved performance.
Determining the Primary Sources of Uncertainty in Retrieval of Marine Remote Sensing Reflectance From Satellite Ocean Color Sensors
Authors: Gilerson Alexander , Herrera-Estrella Eder , Foster Robert , Agagliate Jacopo , Hu Chuanmin , Ibrahim Amir , Franz Bryan
Published: April 2022

Uncertainties in the retrieval of the remote sensing reflectance, Rrs, from Ocean Color (OC) satellite sensors have a strong impact on the performance of algorithms for the estimation of chlorophyll-a, mineral concentrations, and inherent optical properties (IOPs). The uncertainties are highest in the blue bands. The total radiance measured at the top of the atmosphere captures the instantaneous state of the atmosphere-ocean system: the in-water conditions, sky and Sun glint reflected from the wind-roughened ocean surface, as well as light scattered from molecules and aerosols in the atmosphere. Each of these components has associated uncertainties, and when combined with the additional uncertainties from the instrument noise and the atmospheric correction process, they contribute to the total uncertainty budget for the retrieved Rrs. We analyzed the contribution of each component uncertainties to the total Rrs uncertainties in SNPP-VIIRS level 2 products, taking advantage of the spectral differences between the components. We examined multiple scenes in the open ocean and coastal waters at spatial resolutions ranging from 2250 to 5250 m by comparing the retrieved Rrs to in situ measurements made at several AERONET-OC sites and at the MOBY site. It was shown that uncertainties associated with the molecular (Rayleigh) scattering play the most significant role, while the contributions of other components are usually smaller. Uncertainties in Rayleigh scattering are primarily attributed to the variability of Rayleigh optical thickness (ROT) with a standard deviation of approximately 1.5% of ROT, which can largely explain the frequency of negative Rrs retrievals as observed using the current standard atmospheric correction process employed by NASA. Variability of the sky light reflected from the ocean surface in some conditions also contributed to uncertainties in the blue; water variability proportional to Rrs had a very pronounced peak in the green at coastal sites.
High Throughput JPEG 2000 for Video Content Production and Delivery Over IP Networks
Authors: Taubman David , Naman Aous , Smith Michael , Lemieux Pierre-Anthony , Saadat Hassaan , Watanabe Osamu , Mathew Reji
Published: April 2022

ITU-T Rec T.814 | IS 15444-15, known as High Throughput JPEG 2000, or simply HTJ2K, is Part-15 in the JPEG 2000 series of standards, published in 2019 by the ITU and ISO/IEC. JPEG 2000 Part-1 has long been used as a key component in the production, archival and distribution of video content, as the distribution format for Digital Cinema, and an Interoperable Master Format from which streaming video services are commonly derived. JPEG 2000 has one of the richest feature sets of any coding standard, including scalability, region-of-interest accessibility and non-iterative optimal rate control. HTJ2K addresses a long-standing limitation of the original JPEG 2000 family of standards: relatively low throughput on CPU and GPU platforms. HTJ2K introduces an alternative block coding algorithm that allows extremely high processing throughputs, while preserving all other aspects of the JPEG 2000 framework and offering truly reversible transcoding with the original block coded representation. This paper demonstrates the benefits that HTJ2K brings to video content production and delivery, including cloud-based processing workflows and low latency video content streaming over IP networks, considering CPU, GPU and FPGA-based platforms. For non-iterative optimal rate control, HTJ2K encoders with the highest throughputs and lowest hardware encoding footprints need a strategy for constraining the number of so-called HT-Sets that are generated ahead of the classic Post-Compression Rate-Distortion optimization (PCRD-opt) process. This paper describes such a strategy, known as CPLEX, that involves a second (virtual) rate-control process. The novel combination of this virtual (CPLEX) and actual (PCRD-opt) processes has many benefits, especially for hardware encoders, where memory size and memory bandwidth are key indicators of complexity.
Being in the World Locally: Degrowth Business, Critical Realism, and Humanistic Geography
Authors: Nesterova Iana
Published: April 2022

It has been argued that to achieve a genuinely sustainable society, our mode of being in the world needs to change. Understanding macro visions such as the desirable size of our economies remains essential, but concrete ways of being in the world which unite such aspects of our existence as the self, being with others (humans and non-humans) and being in and with nature deserve a much closer attention. Hence, I propose focusing our attention on being once again. But rather than contemplating being as an abstract philosophical category, this paper looks at being in the world in this dual sense: we are part of the cosmos, of the web of existence and at the same time we are in the world locally, in concrete places and locations characterized by particular cultural attributes, political-economic systems, climate and landscape. This nature of being applies to individual humans and human organizations. This paper focuses specifically on business as one type of organizations. I employ the concept of degrowth business, the philosophy of critical realism and humanistic geography as lenses to enhance and deepen our understanding of what it could mean and look like for a business to be in the world locally and more sustainably. To understand what it could mean and look like in reality, I offer a case of a firm from Northern Sweden specializing in vertical hydroponic agriculture.
A Review on Augmented Reality Authoring Toolkits for Education
Authors: Dengel Andreas , Iqbal Muhammad Zahid , Grafe Silke , Mangina Eleni
Published: April 2022

Creating pedagogically sound, interactive Augmented Reality (AR) experiences supporting situated and experiential learning remains a challenge to teachers without programming skills. To integrate AR in the everyday classroom, teachers need to be capable of designing their own immersive experiences for their students, which is why an analysis of existing authoring toolkits is necessary to identify suitable tools for educational application development and future research directions in terms of educational AR. We identified “easy access”, “GUI-based design”, and “interactive contents” as needs of teachers for designing AR content for the classroom. Based on these needs, we conducted a literature review of 835 documents. Of 80 relevant articles, we included 43 peer-reviewed articles from ACM Digital Library, DBLP, IEEExplore, Scopus, Web of Science, Google Scholar, and miscellaneous other sources in our analysis. We identified 69 different AR authoring toolkits and classified these with regard to their accessibility, their degree of required programming knowledge, and their interactivity. The results show a divergent research landscape with a lack of empirical evaluation. Of 26 openly accessible toolkits, we identified five toolkits addressing the defined needs of teachers for designing interactive AR experiences for the classroom without requiring extensive programming knowledge. We conclude that there are only few tools for the straightforward design of educational AR experiences addressing the needs of teachers and suggest using research-informed and evidence-based criteria for developing AR authoring toolkits for education.
The Antarctic Ice Sheet–A Sleeping Giant?
Authors: Winkelmann Ricarda , Nicola Lena , Notz Dirk
Published: April 2022

The coldest, the windiest, the driest: the continent of Antarctica is a place of extremes. Located at the South Pole, Antarctica is covered by a vast ice sheet, millions of years old and in some areas more than 4,000 m thick. If all this ice were to melt, sea levels would rise by roughly 58 m. Despite its massive size, the Antarctic ice sheet is vulnerable, losing more and more ice as the climate is warming. Most of this ice loss happens along the coast, where the ice sheet slowly flows into the ocean and forms ice shelves, which melt from below because of the comparably warmer ocean water. While the ice loss is still relatively slow right now, several processes could accelerate it and eventually even make it partly unstoppable. Wide-spread ice loss can only be prevented on the long-term if we manage to limit global warming to well below 2°C.
Which Innovative Cropping System for Which Farmer? Supporting Farmers' Choices Through Collective Activities
Authors: Périnelle Anne , Scopel Eric , Berre David , Meynard Jean-Marc
Published: April 2022

Designing innovative cropping systems is an active field of agricultural research challenged by the agroecological transition. One of the challenges is to adapt cropping systems to the diversity of farms and contexts. For instance, in the cotton production zone of Burkina Faso differences between farm resources, agricultural situations and agronomic constraints have resulted in a wide range of farming systems. In this context, to break with the trend toward cotton production, we co-designed eight legume-based innovative cropping systems (ICS) likely to meet the objectives sought and the constraints faced by a wide range of local farmers, thus constituting a “basket of options”. Our approach was to enable each farmer to choose the option they considered best suited to their conditions. To that end, the ICSs were implemented and discussed with farmers in participatory prototyping trials. After one season of co-evaluating the different ICSs, the farmers taking part in the co-evaluation were able to test an ICS on their own farm, by choosing and adapting one of the options. Thirty-nine farmers out of seventy-three chose an ICS to test. They were asked the reasons for their choice. Their selection criteria were analyzed in relation to comments made during collective activities organized in the participatory prototyping trials. To complete this analysis, we built an expert-based farming system typology and a statistical typology based on data collected in a rural household multi-indicator survey (RHoMIS) of 63 farms participating in this study. The two farming system typologies were compared, and the relationships between farming system types and the ICS tested on the farm were analyzed. We found that farmers did not really base their choice on their farming system. Rather, they used a wide range of criteria that varied from farmer to farmer, and they were influenced by what they had learned during the collective activities organized in the participatory prototyping trials.
Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
Authors: Chen Piaopiao , Hu Qiang , Wu Jinfeng
Published: April 2022

Primary giant cell tumors of soft tissues (GCT-STs) are extremely rare soft tissue tumors located both in superficial and in deep soft tissues. Clinically, GCT-ST manifests as a slow-growing, well-defined, painless mass. We report a case of an 88-year-old female patient with upper abdominal distension, fever, and anemia. Laparoscopic exploration revealed a tumor located in the left lobe of the liver with localized rupture and hemorrhage. Postoperative pathology revealed that the tumor was composed of monocytes and osteoclast-like multinucleated giant cells, accompanied by extensive hemorrhage, necrosis, and cytologic atypia. Because mitotic cells are difficult to be detected in pathological diagnosis, combined with immunohistochemistry, the tumor was diagnosed as a giant cell tumor of soft tissue. This case report highlights the primary choice of histology and immunohistochemistry for the correct diagnosis of GCT-ST because preoperative radiological diagnosis is nonspecific and prone to mistakes.
Case Report: Intraarticular Iliopsoas Tendon causes Groin Pain Following Periacetabular Osteotomy
Authors: Gebhardt Sebastian , Nonnenmacher Lars , Wassilew Georgi I. , Zimmerer Alexander
Published: April 2022

A 43-year-old female patient reported persistent iliopsoas-related groin pain following periacetabular osteotomy (PAO) combined with femoroplasty via a direct anterior approach due to CAM morphology. Concomitantly with the planned removal of screws, hip arthroscopy was performed, and the iliopsoas tendon was found to run intraarticularly, resulting in the tendon being impaired in its mobility and being entrapped. The tendon was arthroscopically released. The patient reported relief of the groin pain after the arthroscopic tendon debridement. During PAO combined with capsulotomy, the postoperatively observed intraarticular position of the iliopsoas tendon should be prevented by careful closure of the joint capsule.
Analysis of Targeted Post-operative Nursing Outcome in 1246 Patients with Percutaneous Transhepatic Biliary Drainage
Authors: Yang Xiuchun , Qin Yuelan , Mo Wei , Xiang Hua , Liu Zhichao , Long Jianhua , Xiang Bin
Published: April 2022

Jaundice is a detection index in many disease conditions commonly characterized by yellowish staining of the skin and mucous membranes. This work studies the postoperative care outcome in 1,246 patients (669 males and 577 females) with obstructive jaundice who underwent percutaneous transhepatic biliary drainage (PTBD). These patients were admitted to the interventional vascular surgery department of our hospital from February 2017 to February 2022. From the results, frequent wound re-dressing and maintenance of the drainage tube had significant positive influence on wound healing and patient recovery. The data also showed strict adherence by patients to the doctor’s recommendation advising them to visit the interventional specialist care clinic in time for wound dressing change and drainage tube maintenance. As a result, there was no significant difference in wound allergy, exudation, redness and loosening among patients. A cross-sectional analysis of the effect of age on recovery revealed variations in the healing pattern (wound loosening and the redness) between patients of different ages although the relationship is not very clear due to the limited sample size. Efficient drainage tube maintenance promoted recovery and prevented the occurrence of related complications such as PTBD tube blockage and biliary tract infection. The establishment of the interventional specialist care clinic used in this study additionally ensures patients’ safety, and the incidence of complications have been reduced drastically. These achievements are attributable to the implementation of regular dressing change, drainage tube maintenance and health education for patients with PTBD tube. These practices have also improved on the level of specialty in nursing practice, increased the professional value of nurses and better recognition by the society.
Research Progress and Prospect of Mechanized Harvesting Technology in the First Season of Ratoon Rice
Authors: Fu Jianwei , Ji Chao , Liu Haopeng , Wang Weikang , Zhang Guozhong , Gao Yuan , Zhou Yong , Abdeen Mohamed Anwer
Published: April 2022

The first seasonal harvest technology of ratoon rice requires the least rolling with suitable stubble height required by agronomy when the ratoon rice is nearly mature. Mechanized harvesting in the first season of ratoon rice needs to finish harvesting, threshing, cleaning, straw treatment, grain transportation, grain collection and other processes at one time with a low rolling rate and low rolling degree. Limited by the production conditions such as wet and soft fields, and wet, thick and strong straw, harvest technology with high efficiency and a low rolling rate of ratoon rice in the first season has become the key technology and research focus affecting the yield of ratoon rice. In this paper, we analyzed the planting and popularization of ratoon rice in China, summarized the planting mode and agronomic characteristics of ratoon rice, highlighted the research status of mechanized harvesting equipment for the first season of ratoon rice, especially the specialized harvesters, and illustrated in detail the technical characteristics and research trends of key segments such as chassis, header, and processes such as threshing and cleaning, and straw and stubble treatment of ratoon rice harvesters. In addition, we summarized the application status and value of lightweight technology, performance monitoring and fault diagnosis technology, grain quality detection technology and automatic navigation technology of mechanized harvest in the first season, explained the main problems and reasons affecting the development of ratoon rice harvest mechanization in China, and illustrated the prospect of its research focus and tendency.
Conservation Agriculture in Semi-Arid Zimbabwe: A Promising Practice to Improve Finger Millet (Eleusine coracana Gaertn.) Productivity and Soil Water Availability in the Short Term
Authors: Mbanyele Vengai , Mtambanengwe Florence , Nezomba Hatirarami , Rurinda Jairos , Mapfumo Paul
Published: April 2022

Increasing within-season dry spells in Southern Africa in recent years have generated growing interest in conservation agriculture (CA) to secure crop yields, especially under rainfed systems. This study aimed to evaluate the effects of CA on finger millet’s (Eleusine coracana (L.) Gaertn) growth, yield and water use efficiency on nutrient-depleted sandy soils. Five treatments, namely (conventional tillage (control), conventional tillage + mulch (partial CA1), reduced tillage only (partial CA2), reduced tillage + mulching (partial CA3) and reduced tillage + mulching + intercropping (full CA)) were evaluated over two consecutive cropping seasons (2015/16 and 2016/17) on-farm in the village of Chidora in Hwedza District, southeast Zimbabwe. All mulched treatments had 15–32% more soil water content over the two growing seasons compared to the control. The higher soil water content under the mulched treatments significantly improved finger millet growth and development during both seasons as evidenced by the lower number of days to emergence (3 days less), greater shoot biomass, higher number of productive tillers and higher number of fingers produced. The full CA treatment achieved the best finger millet grain yield of 1.07 and 1.29 t ha−1 during the 2015/16 and 2016/17 seasons, respectively. Full CA, partial CA3 and partial CA1 increased finger millet grain yield by 70%, 14% and 17% during the 2015/16 cropping season compared to the control. During the 2016/17 cropping season, a similar trend in finger millet grain yield was observed. Full CA was also among the most efficient methods in terms of water utilization (WUE), especially during the 2015/16 season. We concluded that CA, particularly when practiced in full, was more effective at offsetting the water limitations imposed by intra-seasonal dry spells on finger millet and significantly improved productivity.
Determination of Discrete Element Modelling Parameters of Adzuki Bean Seeds
Authors: Liu Yan , Mi Guopeng , Zhang Shilin , Li Peng , Huang Yuxiang
Published: April 2022

Using discrete element simulation to reveal the interaction between seed and seed metering devices (SMD) is an important method for developing SMDs. However, due to the lack of discrete element modeling (DEM) parameters of adzuki bean seeds (ABS) in existing literature, it is difficult to develop a suitable SMD. In this study, the DEM parameters of ABS were determined by a combination of physical tests and virtual calibration. Initially, the intrinsic parameters, contact parameters, and angle of repose (AOR) of ABS were measured. The parameters significantly affected AOR were then screened out by Plackett–Burman test. Furthermore, the Steepest Ascent test was used to determine the optimal interval value of significant parameters. Finally, the optimal values of significant parameters were obtained by the Box–Behnken test with an AOR of 23.93° and an error of 0 as targets. The results showed that the coefficient of static friction of ABS–ABS, coefficient of static friction of ABS-photosensitive resin plate, and coefficient of rolling friction of ABS–ABS significantly affected the AOR, and their optimal values were 0.302, 0.282, and 0.043, respectively. The verification test showed that the relative error between simulated and measured values of AOR was 0.67%. This indicated that the determined DEM parameters were accurate and reliable. The results from the study can provide a reference for the selection of DEM parameters in the mechanized seeding process of ABS.
Phytotoxic Effects of Allelochemical Acacetin on Seed Germination and Seedling Growth of Selected Vegetables and Its Potential Physiological Mechanism
Authors: Yan Zhiqiang , Li Peng , Xiao Yali , Cao Lingling , Yao Lunguang
Published: April 2022

Acacetin is a naturally occurring flavonoid that displays multi-pharmacological activities, as well as phytotoxicity. In this study, seeds of four typical vegetables including lettuce (Lactuca sativa L.), radish (Raphanus sativus L.), onion (Allium cepa L.) and cucumber (Cucumis sativus L.) were selected to evaluate the phytotoxic effects of acacetin, and the model plant lettuce, which is also the most sensitive species to acacetin of the four vegetables, was used to research the phytotoxic mechanism of acacetin. Bioassays showed that the germination rate and germination potential of vegetable seeds were both decreased under a high concentration of acacetin. Acacetin displayed strong inhibitory effects on root growth, shoot growth and fresh weight of vegetable seedlings in a concentration dependent manner. After treatments with acacetin, the levels of O2−, H2O2, MDA, free proline and the number of dead cells in lettuce root tips were increased, while the mitosis index (MI) was decreased. These results indicated that acacetin could cause stress on lettuce seedlings and induce the accumulation of reactive oxygen species (ROS) in plant cells, leading to lipid peroxidation and then loss of cell viability and even cell death. Moreover, acacetin influenced the mitosis of the target plant, resulting in a decreased proportion of cells during the division phase. Together, acacetin showed strongly phytotoxic effects on vegetables, and the allelopathic activity mainly depended on the influence of ROS and mitosis of the receptor plant.
Genetic Dissection of Tobacco (Nicotiana tabacum L.) Plant Height Using Single-Locus and Multi-Locus Genome-Wide Association Studies
Authors: Ikram Muhammad , Lai Ruiqiang , Xia Yanshi , Li Ronghua , Zhao Weicai , Siddique Kadambot H. M. , Chen Jianjun , Guo Peiguo
Published: April 2022

Tobacco (Nicotiana tabacum L.) plant height (PH) is a biologically important plant architecture trait linked to yield and controlled by polygenes. However, limited information is available on quantitative trait nucleotides (QTNs), alleles, and candidate genes. The plant height of 94 tobacco accessions and their 126,602 SNPs were measured to conduct a genome-wide association study (GWAS) using four multi-locus (ML) and two single-locus (SL) models to better understand its genetic basis. The ML and SL models detected 181 and 29 QTNs, respectively, across four environments/BLUP; LOD scores ranged from 3.01–13.45, and the phenotypic variance explained (PVE) ranged from 0.69–25.37%. Fifty-two novel, stable QTNs were detected across at least two methods and/or two environments/BLUP, with 0.64–24.76% PVE. Among these, 49 QTNs exhibited significant phenotypic differences between two alleles; the distribution of elite and alternative alleles for each accession ranged from 3–42 and 6–46, respectively, in the mapping population. Seven cross combinations in two directions were predicted using alleles of validated QTNs, including Qinggeng × KY14 for taller plants and RG112 × VA115 for shorter plants. We identified 27 candidate genes in the vicinity of 49 stable QTNs based on comparative genomics, gene ontology (GO), and KEGG enrichment analysis, including AP2, Nitab4.5_0000343g0250.1 (ROC1), Nitab4.5_0000197g0010.1 (VFB1), CDF3, AXR6, KUP8, and NPY2. This is the first study to use genotyping-by-sequencing (GBS) of SNPs to determine QTNs, potential candidate genes, and alleles associated with plant height. These findings could provide a new avenue for investigating the QTNs in tobacco by combining SL and ML association mapping and solid foundations for functional genomics, the genetic basis, and molecular breeding for PH in tobacco.
Advances in Chimeric Antigen Receptor (CAR) T-Cell Therapies for the Treatment of Primary Brain Tumors
Authors: Mount Christopher W. , Gonzalez Castro Luis Nicolas
Published: April 2022

Immunotherapy has revolutionized the care of cancer patients. A diverse set of strategies to overcome cancer immunosuppression and enhance the tumor-directed immune response are in clinical use, but have not achieved transformative benefits for brain tumor patients. Adoptive cell therapies, which employ a patient’s own immune cells to generate directed anti-tumor activity, are emerging technologies that hold promise to improve the treatment of primary brain tumors in children and adults. Here, we review recent advances in chimeric antigen receptor (CAR) T-cell therapies for the treatment of aggressive primary brain tumors, including glioblastoma and diffuse midline glioma, H3 K27M-mutant. We highlight current approaches, discuss encouraging investigational data, and describe key challenges in the development and implementation of these types of therapies in the neuro-oncology setting.
Nitrotyrosine, Nitrated Lipoproteins, and Cardiovascular Dysfunction in Patients with Type 2 Diabetes: What Do We Know and What Remains to Be Explained?
Authors: Jakubiak Grzegorz K. , Cieślar Grzegorz , Stanek Agata
Published: April 2022

Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases (CVDs), which are the most important cause of morbidity and mortality in the population of patients living with DM. DM is associated with lipid metabolism disorders characterized by a decrease in the high-density lipoprotein blood concentration, an increase in the triglyceride blood concentration, and the presence of modified lipoproteins not routinely measured in clinical practice. Nitrated lipoproteins are produced by the nitration of the tyrosyl residues of apolipoproteins by myeloperoxidase. There is some evidence from the research conducted showing that nitrated lipoproteins may play a role in the development of cardiovascular dysfunction, but this issue requires further investigation. It was found that the nitration of HDL particles was associated with a decrease in caspase-3 and paraoxonase-1 activity, as well as a decrease in the activity of cholesterol transport via ABCA1, which reduces the protective effect of HDL particles on the cardiovascular system. Less information has been collected about the role of nitrated LDL particles. Thus far, much more information has been obtained on the relationship of nitrotyrosine expression with the presence of cardiovascular risk factors and the development of cardiovascular dysfunction. The purpose of this paper is to provide an extensive review of the literature and to present the most important information on the current state of knowledge on the association between nitrotyrosine and nitrated lipoproteins with dysfunction of the cardiovascular system, especially in patients living with DM. Moreover, directions for future research in this area were discussed.
A Causal Relationship between Vitamin C Intake with Hyperglycemia and Metabolic Syndrome Risk: A Two-Sample Mendelian Randomization Study
Authors: Liu Meiling , Park Sunmin
Published: April 2022

Excessive oxidative stress can contribute to metabolic syndrome (MetS), and antioxidants can protect against its development. Vitamin C (VC) is a well-known antioxidant, and observational studies have associated a deficiency with an increased MetS risk. This study tested the hypothesis that dietary VC intake caused an inverse relation of MetS and its components risk using a two-sample Mendelian randomization (MR) method in adults ≥40 years in a city hospital-based (n = 58,701) and Ansan/Ansung plus rural (n = 13,598) cohorts. Independent genetic variants associated with dietary VC intake were explored using a genome-wide association study (GWAS) with significance levels of p < 5 × 10−5 and linkage disequilibrium (r2 threshold of 0.001), after adjusting for the covariates related to MetS, in a city hospital-based cohort (n = 52,676) excluding the participants having vitamin supplementation. MR methods, including inverse-variance weighting (IVW), weighted median, MR-Egger, and weighted model, were used to determine the causal relationship between the dietary VC intake and the risk of MetS and its components in Ansan/Ansung plus rural cohorts (n = 11,733). Heterogeneity and leave-one-out sensitivity analyses were conducted. Energy intake, as well as other nutrient intakes, were significantly lower in the low VC intake group than in the high VC intake group, but the incidence of MetS and its components, including hyperglycemia, hypertriglyceridemia, and hypertension, was observationally higher in inadequate low VC intake in the combined cohorts. In MR analysis, insufficient dietary VC intake increased the risk of MetS, hyperglycemia, hypertriglyceridemia, and hypertension in an IVW (p < 0.05). In contrast, only the serum fasting blood glucose concentration was significantly associated with VC intake in weight median analysis (p < 0.05), but there was no significant association of low dietary VC with MetS and its components in MR-Egger. There was no likelihood of heterogeneity and horizontal pleiotropy in MetS and its components. A single genetic variant did not affect their association in the leave-one-out sensitivity analysis. In conclusion, insufficient dietary VC intake potentially increased the MetS and hyperglycemia risk in Asian adults. Low VC intake can contribute to increasing type 2 diabetes incidence in Asians.
Antioxidant Polyphenols of Antirhea borbonica Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke
Authors: Taïlé Janice , Bringart Matthieu , Planesse Cynthia , Patché Jessica , Rondeau Philippe , Veeren Bryan , Clerc Patricia , Gauvin-Bialecki Anne , Bourane Steeve , Meilhac Olivier , Couret David , Gonthier Marie-Paule
Published: April 2022

Metabolic disorders related to obesity and type 2 diabetes are associated with aggravated cerebrovascular damages during stroke. In particular, hyperglycemia alters redox and inflammatory status, leading to cerebral endothelial cell dysfunction, blood–brain barrier (BBB) disruption and brain homeostasis loss. Polyphenols constitute the most abundant dietary antioxidants and exert anti-inflammatory effects that may improve cerebrovascular complications in stroke. This study evaluated the effects of the characterized polyphenol-rich extract of Antirhea borbonica medicinal plant and its major constituent caffeic acid on a high-fat diet (HFD)-induced obesity mouse model during ischemic stroke, and murine bEnd3 cerebral endothelial cells in high glucose condition. In vivo, polyphenols administered by oral gavage for 12 weeks attenuated insulin resistance, hyperglycemia, hyperinsulinemia and dyslipidemia caused by HFD-induced obesity. Polyphenols limited brain infarct, hemorrhagic transformation and BBB disruption aggravated by obesity during stroke. Polyphenols exhibited anti-inflammatory and antioxidant properties by reducing IL-1β, IL-6, MCP-1, TNF-α and Nrf2 overproduction as well as total SOD activity elevation at the cerebral or peripheral levels in obese mice. In vitro, polyphenols decreased MMP-2 activity that correlated with MCP-1 secretion and ROS intracellular levels in hyperglycemic condition. Protective effects of polyphenols were linked to their bioavailability with evidence for circulating metabolites including caffeic acid, quercetin and hippuric acid. Altogether, these findings show that antioxidant polyphenols reduced cerebrovascular, inflammatory and metabolic disorders aggravated by obesity in a mouse model of stroke. It will be relevant to assess polyphenol-based strategies to improve the clinical consequences of stroke in the context of obesity and diabetes.