bluuebunny/crossref_metadata_2025 huggingface dataset:
CD6 regulates CD4 T follicular helper cell differentiation and humoral immunity during murine coronavirus infection
Authors: Cardani-Boulton Amber , Lin Feng , Bergmann Cornelia C.
Published: December 2024

During activation, the T cell transmembrane receptor CD6 becomes incorporated into the T cell immunological synapse where it can exert both co-stimulatory and co-inhibitory functions. Given the ability of CD6 to carry out opposing functions, this study sought to determine how CD6 regulates early T cell activation in response to viral infection. Infection of CD6-deficient mice with a neurotropic murine coronavirus resulted in greater activation and expansion of CD4 T cells in the draining lymph nodes. Further analysis demonstrated that there was also preferential differentiation of CD4 T cells into T follicular helper cells, resulting in accelerated germinal center responses and emergence of high-affinity virus-specific antibodies. Given that CD6 conversely supports CD4 T cell activation in many autoimmune models, we probed potential mechanisms of CD6-mediated suppression of CD4 T cell activation during viral infection. Analysis of CD6 binding proteins revealed that infection-induced upregulation of
Ubash3a
, a negative regulator of T cell receptor (TCR) signaling, was hindered in CD6-deficient lymph nodes. Consistent with greater T cell activation and reduced UBASH3a activity, the T cell receptor signal strength was intensified in CD6-deficient CD4 T cells. These results reveal a novel immunoregulatory role for CD6 in limiting CD4 T cell activation and deterring CD4 T follicular helper cell differentiation, thereby attenuating antiviral humoral immunity.

IMPORTANCE

CD6 monoclonal blocking antibodies are being therapeutically administered to inhibit T cell activation in autoimmune disorders. However, the multifaceted nature of CD6 allows for multiple and even opposing functions under different circumstances of T cell activation. We therefore sought to characterize how CD6 regulates T cell activation in the context of viral infections using an
in vivo
murine coronavirus model. In contrast to its role in autoimmunity, but consistent with its function in the presence of superantigens, we found that CD6 deficiency enhances CD4 T cell activation and CD4 T cell help to germinal center-dependent antiviral humoral responses. Finally, we provide evidence that CD6 regulates transcription of its intracellular binding partner UBASH3a, which suppresses T cell receptor (TCR) signaling and consequently T cell activation. These findings highlight the context-dependent flexibility of CD6 in regulating
in vivo
adaptive immune responses, which may be targeted to enhance antiviral immunity.
Stage-specific function of sphingolipid synthases in African trypanosomes
Authors: Heise Norton , Koeller Carolina M. , Sharif Mohamed , Bangs James D.
Published: December 2024

The protozoan parasite
Trypanosoma brucei
is the only known eukaryote capable of synthesizing the three main phosphosphingolipids: sphingomyelin (SM), inositol phosphorylceramide (IPC), and ethanolamine phosphorylceramide (EPC). It has four paralogous genes encoding sphingolipid synthases (
TbSLS1–4
). TbSLS1 is a dedicated IPC synthase, TbSLS2 is a dedicated EPC synthase, and TbSLS3 and TbSLS4 are bifunctional SM/EPC synthases. IPC synthesis occurs exclusively in the procyclic insect stage (PCF), EPC is limited to the mammalian bloodstream form (BSF), and SM is synthesized throughout the life cycle. TbSLSs are indispensable for the viability of BSF and are, thus, potential drug targets. The relative stage-specific expression of each
TbSLS
paralog was compared, and the results match phosphosphingolipid content. Induction of pan-specific RNAi silencing was lethal in both BSF and PCF. To investigate individual TbSLS functions, separate HA-tagged genes, recoded to be RNAi-resistant (RNAi
R
), were engineered to replace a single allele of the entire
TbSLS
locus within parental BSF and PCF RNAi cell lines. RNAi
R
TbSLS3
and
TbSLS4
both rescued BSF growth under silencing. Expression of RNAi
R
TbSLS1
, normally repressed in BSF, did not rescue BSF viability but was not detrimental to normal
in vitro
growth. RNAi
R
TbSLS1
,
TbSLS3
, and
TbSLS4
were each sufficient to rescue PCF growth, indicating IPC is not essential for PCF viability
in vitro
. All TbSLSs localize to distal Golgi compartments in both BSF and PCF cells. These findings raise interesting questions about the roles of individual phosphosphingolipids in
in vivo
infection of the mammalian and tsetse hosts.

IMPORTANCE

African trypanosomes are eukaryotic pathogens that cause human and veterinary African trypanosomaisis. Uniquely, they synthesize all three major phosphosphingolipid species using four distinct sphingolipid synthases (SLS). This work details the function of each SLS in both bloodstream and insect form parasites. Novel and unexpected sphingolipid dependences are found in each stage. These results are consistent with this metabolic pathway being a valid target for chemotherapeutic intervention.
Genome sequences of
Staphylococcus aureus
RN4220
Authors: Ko Eon-Min , Kim Seonghan
Published: December 2024

In this study, we present whole genome sequences of
Staphylococcus aureus
RN4220. Using PacBio DNA sequencing and
de novo
assembly, we obtained a single contig of 2,697,647 bp, which includes 2,652 predicted genes comprising protein-coding sequences, tRNAs, and rRNAs.
Whole-genome sequencing of three extremophile
Bacillus
sp. strains isolated from the Atacama Desert
Authors: Cavanaugh Nicole T. , Kumar Girish , Couto Frignani Matteo , Thewedros Nathan , Twahirwa Marcello , Riquelme Carlos , Hudson André O. , Chai Yunrong , Godoy-Carter Veronica
Published: December 2024

The Atacama Desert is home to bacteria that use biofilms as a means of protecting themselves against the harsh environment. To inform research regarding this survival mechanism, we cultured and sequenced the genomes of three
Bacillus
sp. isolates from Atacama Desert soil.
Draft genome sequence of
Aureobasidium pullulans
ATCC15233
Authors: Li Shuang , Wu Xiuyun , Meng Jing
Published: December 2024

Aureobasidium pullulans
is a well-studied polyextremotolerant generalist fungus with a ubiquitous distribution, which can efficiently secret extracellular polysaccharides, especially pullulan. Here, we reported the draft genome of
A. pullulans
ATCC15233, whose genome length is 30,444,007 bp, with a GC content of 50.63%.
Genome sequence of
Bradyrhizobium
sp. Ash2021, a free-living
Bradyrhizobium
species isolated from
Pinus radiata
forest soil
Authors: Armstrong Charlotte , Wakelin Steve
Published: December 2024

Bradyrhizobium
sp. Ash2021 is a free-living soil bacterium isolated from a
Pinus radiata
forest in Canterbury, New Zealand. The genome comprises of a 9,328,819 bp chromosome and a 375,468 bp plasmid. The chromosome harbors biosynthesis pathways for auxins, thiazole-oxazole-modified microcins, and polyketide synthase. The plasmid harbors lactate and GlcNAc metabolism genes.
Whole-genome sequencing of novel pathogenic and multidrug-resistant
Kytococcus sedentarius
, causing mortality in fish species (
Labeo rohita
)
Authors: Das Basanta Kumar , Kumar Vikash , Roy Suvra , Mohanty Debasmita , Jana Asim Kumar , Gadnayak Ayushman
Published: December 2024

We present a novel pathogenic and multidrug-resistant
Kytococcus sedentarius
isolated from
Labeo rohita
. The bacterium belongs to the Micrococcales order and has a genome consisting of 2.59 Mb in length and 71.7% GC content.
K. sedentarius
contains 2,393 coding gene sequences, 6 rRNA, 51 tRNA, 1 tmRNA, and 2,173 antimicrobial resistance genes.
Complete genome sequence of strain AEG42_29 (DSM 112329), a member of the genus
Paraconexibacter
isolated from soil
Authors: Vieira Selma , Huber Katharina , Geppert Alicia , Overmann Jörg
Published: December 2024

We report the complete genome sequence of strain AEG42_29, a representative of the genus
Paraconexibacter
isolated from a temperate grassland soil. Its genome codes for several genes involved in stress response, defense, and virulence, which may help this bacterium cope with fluctuating conditions in the soil environment.
Garnet growth in a geological blink of an eye
Authors: Tual L. , Smit M.A. , Cutts J.A. , Musiyachenko K.A. , Kooijman E. , Majka J. , Foulds I. , Ielpi A.
Published: December 2024

Mineral reactions determine the physical and rheological properties of rocks, but whether these reactions occur close to or far from equilibrium and whether they are continuous or pulsed is challenging to unravel. This introduces significant uncertainty in determining the thermomechanical properties and behavior of the crust and estimating the pressure and temperature conditions that rocks underwent during their tectonic history. Here, we employ elemental mapping and high-precision Lu-Hf chronology to investigate whether and to what extent garnet—one of the most important recorders of pressure, temperature, deformation, and time in the lithosphere—keeps up with tectonic processes. The analysis was done on a single 1.2-cm-sized garnet grain from a carbonate-rich mica schist from the Schneeberg Complex (Italy). Five compositionally distinct zones were identified and dated separately. The four inner zones, characterized by trace-elements oscillations, yielded identical ages with a weighted mean of 98.4 ± 0.1 Ma (2σ), whereas the outermost zone yielded 97.8 ± 0.3 Ma. During the first growth pulse, garnet grew at an average radial growth rate of at least 6.2 cm m.y.−1. Nucleation initiated out of equilibrium conditions and resulted in high fluid production that, in turn, boosted garnet growth, episodically limited by the rock’s elements transport permeabilities. This pulsed, ultrafast garnet growth must have occurred over a very limited pressure-temperature window. This example provides a rare glimpse into the discontinuous nature of mineral reactions in metamorphic rocks and highlights garnet as a unique recorder of the processes that occur when such rocks push toward equilibrium.
The Barriers and Challenges in Smart Manufacturing Adoption for SMEs: A Review
Authors: Huang Dayao , Chin Christie Pei-Yee
Published: December 2024

Smart manufacturing, as a buzzword in recent years, is increasingly attracting attention in academia and industry. However, it is challenging for most manufacturing enterprises as they are uncertain about the ROI of smart manufacturing, and they are currently confronting many difficulties and hurdles. In previous studies, most researchers tended to emphasize larger companies while small and medium enterprises (SMEs) received limited attention. To comprehensively understand the barriers and challenges of smart manufacturing adoption faced by manufacturing companies especially SMEs, the author of this paper conducted a systematic review to identify more than 80 barriers and challenges which are classified into five categories: nature of SMEs, technology, organization, environment, and financial. The top factors include high investment, lack of skilled workforce, lack of strategy and awareness, and security issues. Furthermore, the author pointed out that we should not neglect some less frequently mentioned factors, such as limited bandwidth and speed of internet transfer, and the energy needed for data transmission.
Goodbye Multidisciplinary Column!
Authors: Liem Cynthia C. S. , Huber Jochen
Published: December 2024

In June 2017, we were invited to serve as editors of the newly established column on multidisciplinary aspects of Multimedia. Our major goal back then was to portray a look beyond 'the big pond' - multimedia research that is.
VQEG Column: VQEG Meeting June 2023
Authors: Gutiérrez Jesüs , Brunnström Kjell
Published: December 2024

This column provides a report on the last Video Quality Experts Group (VQEG) plenary meeting, which took place from 26 to 30 June 2023 in San Mateo (USA), hosted by Sony Interactive Entertainment. More than 90 participants worldwide registered for the hybrid meeting, counting with the physical attendance of more than 40 people. This meeting was co-located with the ITU-T SG12 meeting, which took place in the first two days of the week. In addition, more than 50 presentations related to the ongoing projects within VQEG were provided, leading to interesting discussions among the researchers attending the meeting. All the related information, minutes, and files from the meeting are available online on the VQEG meeting website, and video recordings of the meeting are available on Youtube.
Overview of Benchmarking Platforms and Software for Multimedia Applications
Authors: Constantin Mihai Gabriel , Vega Maria Torres , Fliegel Karel
Published: December 2024

In a time where Artificial Intelligence (AI) continues to push the boundaries of what was previously thought possible, the demand for benchmarking platforms that allow to fairly assess and evaluate AI models has become paramount. These platforms serve as connecting hubs between data scientists, machine learning specialists, industry partners, and other interested parties. They mostly function under the Evaluation-as-a-Service (EaaS) paradigm [1], the idea that participants that do a certain benchmarking task should be able to test the output of their systems in similar conditions, by being provided with a common definition of the targeted concepts, datasets and data splits, metrics, and evaluation tools. These common elements are provided through online platforms that can even offer Application Programming Interfaces (APIs) or container-level integration of the participants' AI models. This column provides an insight into these platforms, looking at their main characteristics, use cases, and particularities. In the second part of the column we will also look into some of the main benchmarking platforms that are geared towards handling multimedia-centric benchmarks and datasets, relevant to SIGMM.
Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle
Authors: Naito Azuma , Sato Tatsuya , Kimura Iori , Tokuda Nao , Yamauchi Nao , Fusagawa Hiroyori , Yamada Takashi
Published: December 2024

We investigated how training programs varying in contraction frequencies impact the endurance capacity of mouse skeletal muscle, using in vivo supramaximal electrical stimulation to ensure maximal activation of all muscle fibers. Increasing the frequency of contractions during high-intensity training led to increased fatigue resistance and mitochondrial respiratory capacity with fewer repetitions per training session, highlighting the pivotal importance of contraction frequency during exercise training in shaping endurance adaptations in skeletal muscle.
Characterisation of Bioactive Compounds and In Vitro Anticancer and Anthelmintic Activities of Ilex khasiana, an Endangered Species of Holly From Mizoram, India
Authors: Lalnunfela Charles , Lalthanpuii P. B. , Lalremsanga H. T. , Zothansiama  , Lalmuansangi C. , Kumar N. Senthil , Lalhriatpuii T. C. , Lalchhandama Kholhring
Published: December 2024

Ilex khasiana Purkay. is a critically endangered species of holly found only in Khasi Hills and Mizoram, Northeast India. Of its several medicinal uses in the Khasi and Mizo traditional systems, the anticancer and anthelmintic applications remain unexplored. A methanol extract (IKM) and three fractions, namely, butanol (IKM‐B), diethyl ether (IKM‐D) and hexane (IKM‐H) extracts were prepared from the leaves. Cytotoxicity tests were performed in vitro on malignant human alveolar adenocarcinoma (A549) and human colorectal carcinoma (HCT116) cell lines using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5 diphenyltetrazolium bromide (MTT) reduction reaction. All the extracts exerted inhibitory efficacy in the order, IKM‐D > IKM‐B > IKM > IKM‐H. IKM‐D was the most efficacious extract exhibiting the half‐maximal inhibitory concentration (IC50) values of 26.9, 64.04 and 28.61 μg/mL against A549 cells, and 22.77, 69.41 and 18.37 μg/mL against HCT116 cells at 24, 48 and 72 h, respectively. The most bioactive extract, IKM‐D, was used for further anticancer tests. It induced apoptosis as indicated by red fluorescence in the dead cells. The apoptotic index values were determined at 33.5, 55.18 and 57.62 in A549 cells, and 32.47, 54.29 and 62.55 in HCT166 cells at the corresponding concentrations of 25, 50 and 100 μg/mL. It also caused significant clonogenicity by repressing cancer proliferation, but only at a concentration of 100 μg/mL. Surviving fractions of the cancer cells following extract treatment at 25, 50 and 100 μg/mL were 52.16%, 47.56% and 21.77% for A549 cells, and 52.56%, 48.12% and 8.42% for HCT116 cells. The plant extract also caused concentration‐dependent inhibition of colony formation against both cell lines. Anthelmintic activity was demonstrated in an intestinal cestode, Raillietina galli. Scanning electron microscopy revealed hallmark anthelmintic alterations on the body parts of the parasite. The GC‐MS analysis showed that the plant extract is mainly composed of a phenol, 2,6‐di‐tert‐butylphenol. High‐performance thin‐layer chromatography (HPTLC) fingerprinting and quantification indicated the presence of β‐sitosterol at an amount of 198.68 ng. The two compounds were predicted by computational modelling to have high binding potentiality on β‐tubulin, a common anticancer and anthelmintic target. The findings established that I. khasiana leaves contain bioactive principles that caused inhibitory effects on carcinoma cells and produced anthelmintic effects on cestode parasite. The study advocates further investigations into the identification of the exact molecules, the precise mode of actions and therapeutic tests, as well as the need for conservation of the rare species of holly.
Figure S7 from Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer
Authors: Oyama Koki , Nakata Kohei , Tsutsumi Chikanori , Hayashi Masataka , Zhang Bo , Mochida Yuki , Shinkawa Tomohiko , Hirotaka Kento , Zhong Pingshan , Date Satomi , Luo Haizhen , Kubo Akihiro , Higashijima Nobuhiro , Yamada Yutaka , Abe Toshiya , Ideno Noboru , Koikawa Kazuhiro , Iwamoto Chika , Ikenaga Naoki , Ohuchida Kenoki , Onishi Hideya , Morisaki Takashi , Kuba Keiji , Oda Yoshinao , Nakamura Masafumi
Published: December 2024

Vaccination experiments with KPC1 shNC/shATG5 and confirmation of the effect of CQ treatment
Figure S4 from Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer
Authors: Oyama Koki , Nakata Kohei , Tsutsumi Chikanori , Hayashi Masataka , Zhang Bo , Mochida Yuki , Shinkawa Tomohiko , Hirotaka Kento , Zhong Pingshan , Date Satomi , Luo Haizhen , Kubo Akihiro , Higashijima Nobuhiro , Yamada Yutaka , Abe Toshiya , Ideno Noboru , Koikawa Kazuhiro , Iwamoto Chika , Ikenaga Naoki , Ohuchida Kenoki , Onishi Hideya , Morisaki Takashi , Kuba Keiji , Oda Yoshinao , Nakamura Masafumi
Published: December 2024

Autophagy inhibition in cancer cells induces the activation of DCs in several murine autophagy-deficient PDAC models
Supplementary Table S11 from Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes
Authors: Patkar Sushant , Mannheimer Joshua , Harmon Stephanie A. , Ramirez Christina J. , Mazcko Christina N. , Choyke Peter L. , Brown Gregory Thomas , Turkbey Baris , LeBlanc Amy K. , Beck Jessica A.
Published: December 2024

Demographics and progression free survival outcome data of all human patients analyzed in this study.
Supplementary Figure S2 from Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma
Authors: Movva Sujana , Seier Kenneth , Avutu Viswatej , Banks Lauren B. , Chan Jason , Chi Ping , Dickson Mark A. , Gounder Mrinal M. , Kelly Ciara M. , Keohan Mary L. , Maki Robert , Rosenbaum Evan , Salcito Tiffany , Rodriguez Kaithleen , Dempsey Rebecca , Meyers Paul A. , Cohen Seth M. , Hensley Martee L. , Konner Jason A. , Schram Alison M. , Lefkowitz Robert A. , Erinjeri Joseph P. , Qin Li-Xuan , Tap William D. , D’Angelo Sandra P.
Published: December 2024

Supplementary Figure 2. Overall survival by (A) cohort and (B) histology.
Table S4 from Anlotinib plus TQB2450, a PD-L1 Antibody, in Patients with Advanced Alveolar Soft Part Sarcoma: A Single-Arm, Phase II Trial
Authors: Tan Zhichao , Wu Yan , Fan Zhengfu , Gao Tian , Guo Wei , Bai Chujie , Xue Ruifeng , Li Shu , Zhang Lu , Wang Xinyu , Jia Ling , Liu Jiayong
Published: December 2024

Patient representativeness table
Supplementary Appendix S2 from Efficacy, Safety, and Influence on the Tumor Microenvironment of Neoadjuvant Pembrolizumab plus Ramucirumab for PD-L1–Positive NSCLC: A Phase II Trial (EAST ENERGY)
Authors: Aokage Keiju , Koyama Shohei , Kumagai Shogo , Nomura Kotaro , Shimada Yoshihisa , Yoh Kiyotaka , Wakabayashi Masashi , Fukutani Miki , Furuya Hideki , Miyoshi Tomohiro , Tane Kenta , Samejima Joji , Taki Tetsuro , Hayashi Takuo , Matsubayashi Jun , Ishii Genichiro , Nishikawa Hiroyoshi , Ikeda Norihiko , Tsuboi Masahiro
Published: December 2024

Supplementary Appendix S2: EAST_ENERGY_Protocol_amendment.
Data from First-in-Human Dose-Escalation Study of Fianlimab, an Antilymphocyte Activation Gene-3 Antibody, with Cemiplimab in Patients with Advanced Malignancies
Authors: Lakhani Nehal J. , Papadopoulos Kyriakos P. , Johnson Melissa Lynne , Park Haeseong , Wang Ding , Yap Timothy A. , Dowlati Afshin , Maki Robert G. , Ulahannan Susanna , Lynce Filipa , Kelly Karen , Williamson Stephen , Malhotra Jyoti , Chen Shuquan , Gonzalez Ortiz Ana , Jankovic Vladimir , Paccaly Anne , Masinde Sheila , Mani Jayakumar , Lowy Israel , Gullo Giuseppe , Sims Tasha , Kroog Glenn
Published: December 2024

AbstractPurpose:
Preclinical data indicate that fianlimab (antilymphocyte activation gene-3) plus cemiplimab (anti–PD-1) enhances antitumor activity. Here, we report prespecified final analyses of the dose-escalation part of a first-in-human, phase 1 study (NCT03005782) of fianlimab as monotherapy and in combination with cemiplimab in patients with advanced malignancies.
Patients and Methods:
Adult patients received 1 to 40 mg/kg of fianlimab plus 350 mg of cemiplimab every 3 weeks (Q3W) across various dose-escalation schedules. Primary objectives were the rate of dose-limiting toxicities, adverse events (including immune mediated), deaths, laboratory abnormalities, and pharmacokinetics. Secondary outcomes were objective response rate, best overall response, duration of response, and antidrug antibody variables.
Results:
Seventy-eight patients were enrolled (fianlimab + cemiplimab, n = 47; fianlimab monotherapy, n = 31). One patient treated with 3 mg/kg fianlimab + cemiplimab experienced dose-limiting toxicities, including increased blood creatine phosphokinase and myasthenic syndrome. No maximum tolerated dose was reached. Any-grade treatment-emergent adverse events occurred in 90% of patients with fianlimab monotherapy, in 87% of patients with fianlimab + cemiplimab, and in 87% of patients who transitioned from monotherapy to combination therapy. Fianlimab pharmacokinetics were dose proportional and similar in monotherapy and combination therapy. Across patients who received fianlimab + cemiplimab, five achieved a partial response, three of whom experienced a response after transitioning from monotherapy to combination therapy. Fianlimab 1,600 mg Q3W (20 mg/kg in an 80-kg individual) is the selected dose for phase 2 and phase 3 studies.
Conclusions:
Fianlimab as monotherapy and in combination with cemiplimab demonstrated acceptable safety and preliminary antitumor activity, which is generally consistent with previous reports of cemiplimab.
Model nedostatne sestrinske skrbi (B. J. Kalisch)
Authors: Jurić Marina , Đevenica Viktorija , Fabijanić-Bofanec Ružica
Published: December 2024

Uvod: Model nedostatne sestrinske skrbi predstavlja relativno nov koncept koji se usmjerava na situacije u kojima je sestrinska skrb pacijentima u potpunosti izostavljena, pružena djelomično ili odgođena. Ciljevi su rada prikaz modela nedostatne sestrinske skrbi, analiza njegovih temeljnih aspekata i utvrđivanje temeljnih uzroka nedostatne sestrinske skrbi u bolnicama. Ovaj stručni rad usmjeren je na opis i definiciju modela nedostatne sestrinske skrbi te na evaluaciju modela uzimajući u obzir određene kriterije među kojima su jasnoća, jednostavnost, značaj, prikladnost, mogućnost testiranja i prihvatljivost. Uvažavanje modela nedostatne sestrinske skrbi u okviru cjelokupnog zdravstvenog sustava može imati pozitivan utjecaj na razumijevanje važnosti pružanja cjelokupne skrbi, čime bi se ostvarilo što brže ozdravljenje te smanjila patnja i bol pacijentu.Metode: Prilikom izrade ovog rada, pretraživana je literatura na engleskom jeziku putem centra za online baze podataka te putem pretraživača kao što su EBSCO, Pubmed i Medline. Prilikom pretraživanja korišteni su engleski izrazi iz MeSH-a „missed care“, „patient safety“ i „nursing theory“. Za prikaz opisa modela i analizu pretraživanjem je pronađeno deset članaka.Rezultati: Prikazani su temeljni elementi nedostatne sestrinske skrbi, kao i razlozi nastajanja istih. Nakon prikazivanja modela, prikazana je i evaluacija istog.Zaključak: Beatrice J. Kalisch utvrdila je devet aspekata koji se u skrbi često izostavljaju te uzroke tih propusta. Uvažavanje modela nedostatne sestrinske skrbi u okviru cjelokupnog zdravstvenog sustava može imati pozitivan utjecaj na razumijevanje važnosti pružanja cjelokupne skrbi, kako bi se ostvario što brži oporavak te smanjila patnja i bol kod pacijenta.
Approach to the Diagnosis and Management of Complex Fascicular Ventricular Tachycardias
Authors: Wong Christopher X. , Hsia Henry H. , Lee Adam C. , Hayward Robert M. , Johnson Colleen J. , Antezana-Chavez Edgar , Khmao Pichmanil , Scheinman Melvin M.
Published: December 2024

Complex ventricular tachycardias involving the fascicular system (fascicular ventricular tachycardias [FVTs]) can be challenging. In this review, we describe our approach to the diagnosis and ablation of these arrhythmias with 10 illustrative cases that involve (1) differentiation from supraventricular tachycardia; (2) assessment for atypical bundle branch reentry and other interfascicular FVTs; (3) examination of P1/P2 activation sequences in sinus rhythm, pacing, and tachycardia; and (4) entrainment techniques to establish the tachycardia mechanism and aid circuit localization. To summarize, 5 cases had prior ablation with 2 previously misdiagnosed as supraventricular tachycardia. A short His-ventricular interval supported ventricular tachycardia. Atrial stimulation could initiate and entrain 4 FVTs. P1 potentials were recorded in all cases of left posterior FVT. Entrainment at P1 and P1 to P2 connection sites at the mid-septal region, and the postablation emergence of a late P1 with decremental properties, is consistent with the left septal fascicle being the slowly conducting, retrograde limb of the left posterior FVT circuit. Ablation targeting the mid-septal left septal fascicle and P1 to P2 connection sites successfully eliminated left posterior FVT. Right ventricular apical pacing was useful in differentiating bundle branch reentry and focal FVTs from reentrant FVTs. Two cases exhibited bundle branch reentry and other interfascicular FVTs. Three cases were postinfarct FVTs involving the LPF, where pacing and entrainment at sites of conduction system potentials were able to localize sites critical for ablation, in contrast to previously unsuccessful substrate modification. In conclusion, several ventricular tachycardia mechanisms involving the fascicular system can occur in both structurally normal and abnormal hearts. A high index of suspicion is required given their rarity and potential for misdiagnosis. Once identified, we emphasize a structured approach to the diagnosis and management of FVTs to confirm the mechanism and localize suitable ablation targets involving careful recording of conduction system potentials and pacing/entrainment maneuvers.
Detectability and cortical depth dependence of stimulus-driven high-frequency BOLD oscillations in the human primary somatosensory and motor cortex
Authors: Hodono Shota , Polimeni Jonathan R. , Reutens David , Cloos Martijn A.
Published: December 2024

In functional magnetic resonance imaging (fMRI), neural activity is inferred from the associated hemodynamic response. However, the degree to which hemodynamics can track dynamic changes in neuronal activity, and thus the ultimate temporal resolution of fMRI, remains unknown. To evaluate the detectability of stimulus-driven high-frequency blood oxygenation level dependent (BOLD) signal oscillations in functionally and vascularly distinct cerebral cortical areas, stimuli up to 0.5 Hz were used to evoke activation in the primary somatosensory and motor cortex. Despite their functional and vascular differences, a similar frequency dependence was observed in both cortical areas. We then proceeded to investigate these signals at different levels of the cortical vascular hierarchy, using cortical depth as a proxy. We observed that, above 0.33 Hz, the BOLD response amplitude decreased faster with increasing frequency near the pial surface than in the parenchyma, suggesting that, in addition to exhibiting high spatial specificity, parenchymal signals—accessible with high spatial resolution imaging—also attenuate less rapidly when the stimulus frequency is increased. In addition, as the stimulus frequency increased, we observed larger relative phase differences in the BOLD oscillations across cortical depths. When averaged across depths, these signals can thus interfere destructively, suggesting that high spatial resolutions can avoid this phase cancellation and thereby aid in the detection of rapid BOLD oscillations.
The recognition of Asplenium loriforme from Asplenium angustum (Aspleniaceae) based on morphology and distribution
Authors: REIS ATILES , LINO VANESSA , MYNSSEN CLAUDINE MASSI , SYLVESTRE LANA DA SILVA
Published: December 2024

We review the identification of Asplenium angustum, its type locality, and its occurrence as an endemic species from the Atlantic Forest of Brazil. To assess these matters, the itinerary of the Freyreiss expeditions through Brazil in 1814 is discussed. Based on the morphology of laminae and spores, we assume the plants from the Amazon Forest as a distinct species, one that should be recognized under the published name A. loriforme. Lectotypes are designated for A. angustum and A. serratum var. caudata.
Pleopeltis glandulosa (Polypodiales: Polypodiaceae), a new species from the Prepuna district of Monte biogeographic province in Argentina
Authors: ARANA MARCELO D. , SLANIS ALBERTO , BULACIO EVA
Published: December 2024

Pleopeltis glandulosa sp. nov. (Polypodiaceae) is described as new species from the Prepuna, a xeric environment dominated by columnar Cactaceae of the biogeographic province Monte. It is characterised by having laminar bases truncate, adaxially glabrous and abaxially completely covered with scales, the scales margins with glandular papillae, and the apices filiform, with a conspicuous glandular apical cell with mucilage. Morphologically, P. glandulosa most resembles P. thyssanolepis, not recorded till the moment in Argentinian flora, but widespread from Mexico to Bolivia, because of its strongly bicolorous rhizome scales, pinnatifid laminae with the abaxial surface covered by scales, and obscure veins, but differs mainly by the glandular trichomes at the margins of rhizomatic scales, and laminar scales with glandular papillae at the margins and the conspicuous glandular apical cell, the alate stipes, and the inconspicuous hydathodes.
Contribution to subfamily Rhaphidophorinae Walker, 1869 (Orthoptera: Rhaphidophoridae) in China IX: New additions of Rhaphidophora from Yunnan and Xizang
Authors: QIN YANTING , BIAN XUN
Published: December 2024

This paper describes three new species of Rhaphidophora from Yunnan and Xizang, China and the female sex of Rhaphidophora heterodentis Shen, Wang & He, 2024. All the specimens are deposited in Guangxi Normal University.
Morphological redescription and population genetics of Pagastia (Pagastia) orientalis (Tshernovskij, 1949) (Diptera: Chironomidae: Diamesinae)
Authors: SEMENCHENKO ALEXANDER A. , YAGODINA VIKTORIIA D. , SELIVERSTOV NIKITA A. , MAKARCHENKO EUGENYI A.
Published: December 2024

Pagastia (P.) orientalis (Tshernovskij, 1949) is redescribed by morphology of adult male from East Palaearctic with remarks on some variability of morphological features and with consideration of population genetics of species, namely population structure and variability from 24 localities belonging to 10 groups.  Population genetic analysis of P. (P.) orientalis revealed multiple haplotypes (209 haplotypes for 213 samples) and a high level of haplotype diversity—0.999±0.001. The results of neutrality tests were significant (P<0.01) and showed negative values, which may indicate population expansion in the past. Clustering of haplotypes into haplogroups was shown, the differentiation between which is significant (P<0.001) while the gene flow was almost virtually absent, which may affect at the level of genetic diversity of a single population.
A remarkable new genus and species of Mictini from southern China (Heteroptera: Coreidae: Coreinae)
Authors: XUN HARVEY , GAO HAO-RAN , YIN ZI-XU
Published: December 2024

In this paper, we describe a new genus, Phyllomictis gen. nov., to accommodate a new species of the tribe Mictini from southern China, Phyllomictis chinensis sp. nov. The new genus is morphologically similar to genera Derepteryx White, 1839 and Helcomeria Stål, 1873 but shows substantial genetic divergence and differs in the pronotum, hind femora, and hind tibiae. We discuss the potential distribution range and relationships, and provide a key to the genera of Mictini in China.
First records of Micranurida and Philotella (Collembola, Neanuridae, Pseudachorutinae) from China with the description of three new species
Authors: GAO YAN , PALACIOS-VARGAS JOSÉ G. , ARANGO ANGELA , BU YUN
Published: December 2024

The genus Micranurida Börner, 1901 and Philotella Najt & Weiner, 1985 are reported from China for the first time, with the following new species Micranurida hunanensis sp. nov. from the Hunan province, Central China, Philotella glabrasterna sp. nov. and Philotella subiasi sp. nov. from the Hebei province, North China.
New species of Coccidella Hambleton and Rhizoecus Kunckel d’Herculais from South America (Hemiptera: Rhizoecidae)
Authors: SCHNEIDER SCOTT A. , LAPOLLA JOHN S.
Published: December 2024

Two new species of root mealybugs (Hemiptera: Rhizoecidae) from South America are described and illustrated based on the morphology of the adult females: Coccidella advena Schneider & LaPolla, sp. nov. from Peru and Rhizoecus peripotaro Schneider & LaPolla, sp. nov. from Guyana and Peru. Both species were collected with colonies of Acropyga ants (Hymenoptera: Formicidae) but only R. peripotaro was found to be trophobiotic; C. advena was ignored by the ants and is considered to be free-living. A guide to aid in identification is provided for each species.
Boosting Coffee Yields and Water Productivity: A Review of Drip Irrigation in Ethiopia
Authors: Tadesse Minda , Asefa Addisu
Published: December 2024

This review evaluates the effects of different irrigation methods on coffee yield and water productivity (WP) in Ethiopia's Jimma and Wollega zones, aligning with global trends. Drip irrigation consistently results in the highest coffee yields, producing 3870 kg ha-1 in Jimma at Melko, a 48% increase over surface irrigation and a 142% increase over rainfed conditions. In East Wollega at Wayu, drip irrigation yields 2035 kg ha-1, 45% higher than surface irrigation and 213% higher than rainfed farming. Surface irrigation, although less efficient than drip, still offers significant improvements over rainfed methods, with cheery yields of 3000 kg ha-1 in Jimma at Melko, 2330 kg ha-1 in Jimma at Gera district, and 1402 kg ha-1 in West Wollega at Haru district, demonstrating increases of 63%, 48%, and 115%, respectively, over rainfed conditions. Rainfed agriculture consistently delivers the lowest yields, highlighting its vulnerability to water scarcity, with only 1600 kg ha-1 in Jimma at Melko and 650 kg ha-1 in West Wollega at Haru district. The review emphasizes the need for better irrigation and agronomic practices to boost productivity and climate resilience in Ethiopian coffee production. Drip irrigation also achieves the highest WP, with 0.38 kg m-³ in Jimma (Melko) and 0.17 kg m-³ in East Wollega (Wayu), surpassing the lower WP values of surface irrigation and rainfed methods. The findings advocate for more efficient irrigation techniques to enhance coffee yield and WP, in line with global practices.
Addressing Depression Through Faith: The Development and Theoretical Underpinnings of Religious Savior-Centered Psychotherapy (RSCP)
Authors: Hesari Negin , Dehkordi Mahnaz , Pasandideh Abbas , Fattahzadeh Mir.Farrokh , Nami Forough , Mohammadzadeh Atena
Published: December 2024

Religious Savior-Centered Psychotherapy (RSCP) is an innovative, faith-based therapeutic approach that integrates religious principles with evidence-based psychological frameworks, including Positive Psychology and Quality of Life Therapy (QOLT). Rooted in the Shi’ah Islamic tradition, RSCP emphasizes the transformative role of faith in a Savior while incorporating universal concepts of meaning, resilience, and well-being, making it adaptable to diverse religious and cultural contexts that share a belief in a Savior figure. RSCP draws heavily on the concept of "active anticipation" of the Imam Mahdi (PBUH), emphasizing purposeful action and hope for a just and utopian world. Within Shi’ah Islam, anticipation is not a passive state but a dynamic process of striving toward personal and societal transformation. Narrations extol the awaiting individual's status, portraying them as divine justice agents whose hope-filled and goal-oriented actions align with religious ideals of worship and well-being. This dynamic interplay between individual transformation and societal harmony makes RSCP a comprehensive model addressing both micro-level mental health needs and macro-level cultural aspirations. This therapeutic model builds on the parallels between Islamic teachings and positive psychology principles, such as hope, goal setting, and mental well-being. RSCP leverages the psychological benefits of utopian thinking, which fosters resilience, purpose, and social connection, aligning with Frankl’s emphasis on meaning and Adler’s focus on social connectedness. Additionally, RSCP integrates aspects of Quality of Life Therapy (QOLT) to operationalize the pursuit of a "Full Life," a concept echoed in positive psychology. By prioritizing individual circumstances and emphasizing meaning-centered actions, RSCP holistically addresses emotional, psychological, and spiritual dimensions of well-being. RSCP is adaptable across different religious contexts. For example, in Christian traditions, it could center on the anticipation of the second coming of Christ (PBUH), while in other religious frameworks, similar Savior-centric beliefs could guide the therapeutic process. This approach not only aids in achieving personal fulfillment but also offers a framework for fostering broader societal harmony and justice. Moreover, RSCP has the potential to fulfill intrinsic human desires for perfection, security, justice, and unity. It should be noted that, due to the novelty of this treatment method and the need for further scientific research to provide readers with data on its validity, as well as to explore its qualitative and quantitative stages, this article focuses on its theoretical foundations. A more detailed description of its components, along with the qualitative and quantitative phases of its development, is provided in other extended articles.
The Mechanism of Formation of the Vibrational-Rotational Spectrum of the HCL Molecule
Authors: Nurmurodova Gulshan , Murodov Gulomhon , Khujamov Utkir
Published: December 2024

In this work, the harmonic and anharmonic vibrational frequencies of the HCl molecule have been determined by using the density functional theory method. Calculations have been performed at the B3LYP/6-311++G (3dp, 3df) levels of theory. Transitions between energy levels are analyzed in terms of wavenumber. The rotational constants of the HCl molecule, the wavenumbers corresponding to the rotational structure of the P, R, and Q branches in the spectrum, and their relative intensities at temperatures of 100, 200, and 300 K are calculated, and vibrational-rotational spectra are simulated. The vibrational-rotational spectrum of the HCl molecule is obtained in the range of 2600-3100 cm-1. It has been theoretically shown that when the distance between atomic nuclei in the HCl molecule increases compared to the steady state, the R branch in the spectrum, and when it decreases, the P branch is formed. Rotational constants and corresponding frequencies are calculated for each fundamental transition in rotational energy levels. All calculations use empirical and non-empirical methods. For H35Cl and H37Cl molecules, graphs of the number of fundamental transitions (m) in rotational energy levels and the wave number corresponding to these transitions are drawn. It is in good agreement with all scale experiment results. It is verified that the rotational constants (B) corresponding to the general degree of degeneration (2J+1)2 are similar to the values observed in the literature.
GIS and AHP-Based Assessment of Land Suitability and Water Availability for Surface Irrigation in Beles Sub-Basin, Ethiopia
Authors: Abawa Alemnesh , Berihune Zigiybel , Teklemariam Alayu , Wereta Etaferahu
Published: December 2024

Assessing available water resources and identifying suitable land for irrigation at the basin level are crucial for effective planning and decision-making in irrigation development projects. Therefore, this study aims to utilize the Geographic Information System (GIS) and the Analytic Hierarchy Process (AHP) technique to evaluate surface irrigation suitability and surface water availability in the Beles Basin. We analyzed surface water availability by constructing a flow duration curve (FDC) and assessing the 90% available flow of the Beles River. Meanwhile, land surface suitability was determined through a GIS-based multi-criteria evaluation (MCE). This method integrates various factors, including slope, proximity to rivers, soil characteristics (type, texture, depth, drainage), proximity to roads, and land use and land cover. These factors were weighted using pair-wise comparison matrices to determine their relative importance in assessing physical land suitability. The results revealed that approximately 13.84%, 73.05%, and 13.11% of the catchment area were highly, moderately, and marginally suitable for irrigation, respectively. Regarding water availability, the FDC analysis indicated that the Beles River maintains a 90% available flow of 1.6 m3/s throughout the year. Consequently, in December, the river can only irrigate 0.25% of the total irrigable land, whereas from May to September, it can irrigate the entire irrigable area. The river's low flow presents opportunities for extensive irrigation during the wet season but limits irrigation during the dry season. Therefore, the implementation of water storage structures is imperative to facilitate irrigation across the entire potential land during periods of low flow.
Analysis of Clinical Data on the Treatment of Type 2 Diabetes with BMPRP
Authors: Liu Baochi , Gao Xiong , Chen Yuanhuai , Zheng Ruping , Dong Qiqiang , Wang Jingbo
Published: December 2024

Objective: This study aims to comprehensively analyze the factors influencing the efficacy of bone marrow platelet-rich plasma (BMPRP) therapy in patients with type 2 diabetes mellitus. Methods: In this clinical investigation, autologous bone marrow was harvested from participants, followed by the isolation of BMPRP. Patients then underwent ultrasound-guided infusion of BMPRP directly into the pancreas. The follow-up period for evaluating treatment outcomes spanned one year, during which various factors potentially affecting the therapeutic effects were systematically analyzed. Results: A total of 49 patients diagnosed with type 2 diabetes mellitus received BMPRP pancreatic infusion as a treatment modality. Among these patients, 32 demonstrated a positive response to the therapy, while 17 experienced no significant improvement. Notably, in the effective treatment group, fasting blood glucose levels exhibited a significant reduction after one month of intervention. Additionally, glycosylated hemoglobin (HbA1c) levels showed a substantial decrease at the three-month mark, and a gradual decline in insulin dosage requirements was observed over time. In contrast, changes in C-peptide levels were not pronounced. Analysis of the ineffective treatment group revealed that these patients often had obesity, demonstrated minimal physical activity, and did not adhere to dietary recommendations for carbohydrate control. Conclusion: The findings suggest that BMPRP pancreatic infusion can improve pancreatic function and glycemic control in type 2 diabetes patients. However, for optimal outcomes, it is crucial to combine this therapy with a regimen that includes regular exercise and strict management of carbohydrate intake. This multifaceted approach promises to enhance the effectiveness of BMPRP therapy and contribute to better overall management of type 2 diabetes.
Relentless Angina of a Scarred Heart
Authors: Abbas Eslam , Mahdy Ahmed , Mansy Shady
Published: December 2024

Refractory anginal pain affects nearly 5-10% of stable coronary artery disease patients, and maximizing the anti-ischemic medical therapy is the standard first-line treatment. The presence of a scarred myocardial territory of the epicardial coronary chronic total occlusion (CTO) limits the implementation of other modalities, such as angioplasty and surgical bypass. Accordingly, this subset of patients, who show poor response to medical treatment with the absence of considerable reversible ischemia, bears an additional burden of persistent angina besides the structural and functional complications resulting from their scarred hearts. In this report, a patient, with compensated ischemic cardiomyopathy, complaining of disabling stable angina was indicated for diagnostic coronary angiography that showed a chronic total occlusion (CTO) at the mid-segment of the left anterior descending coronary artery (LAD) and otherwise no significant stenoses in the epicardial coronary tree. After the failure of maximized anti-ischemic medical therapy, the patient underwent elective percutaneous intervention (PCI) to the left anterior descending coronary artery (LAD) chronic total occlusion (CTO) with 2 overlapping drug-eluting stents that yielded a favorable outcome on patient follow-up even though a myocardial perfusion imaging failed to show considerable reversible ischemia at the left anterior descending coronary artery (LAD) territory. The report points out that elective chronic total occlusion (CTO) revascularization may alleviate anginal pain, despite the absence of a considerable macroscopic ischemia, after failure of a maximized anti-ischemic medical regimen.