bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Femoral Artery Flow-Mediated Dilation and Muscle Oxygen Saturation Parameters in Healthy, Young Individuals
Authors: Pinheiro Vivian dos Santos , da Silva Tavares Anna Carolina Faria , Volino-Souza Mônica , de Oliveira Gustavo Vieira , Alvares Thiago Silveira
Published: February 2023

Flow-mediated dilation (FMD) and muscle oxygen saturation (StO2) are measurements utilized to assess macro- and microvascular function, respectively. Macro- and microvascular dysfunction may occur differently depending on the clinical condition. Since microvascular responsiveness can influence upstream conduit artery hemodynamics, the present study aimed to investigate whether a correlation between FMD and muscle StO2 parameters exists. Sixteen healthy, young individuals were enrolled in this study. Femoral artery FMD and tibial anterior muscle StO2 were evaluated by ultrasound and near-infrared spectroscopy, respectively. The FMD and muscle StO2 parameters were assessed by employing a vascular occlusion test (VOT). The oxygen resaturation rate was determined by calculating the upslope of StO2 immediately after occlusion and the magnitude of reperfusion as the difference between the highest and lowest StO2 value achieved during the reperfusion phase. The oxygen desaturation rate and the magnitude of desaturation during the VOT were also evaluated. A significant correlation between the FMD and oxygen resaturation rate (r = 0.628; p = 0.009), magnitude of reperfusion (r = 0.568; p = 0.022), oxygen desaturation rate (r = −0.509; p = 0.044), and magnitude of desaturation (r = 0.644; p = 0.007) was observed. This study demonstrated a moderate association between the femoral artery FMD and tibial anterior StO2 parameters in young individuals.
Impact of Endophthalmitis on the Risk of Acute Myocardial Infarction in Ankylosing Spondylitis Patients: A Population-Based Retrospective Cohort Study
Authors: Lin Ting-Yi , Lai Yi-Fen , Chien Wu-Chien , Chen Yi-Hao , Chung Chi-Hsiang , Chen Jiann-Torng , Chen Ching-Long
Published: February 2023

Many studies have demonstrated an increased cardiovascular (CV) risk in ankylosing spondylitis (AS) patients. Nevertheless, the influence of an endophthalmitis episode toward the future risks of acute myocardial infarction (AMI) in AS patients has been unclear. The objective of this study was to explore the impact of endophthalmitis on AMI risk in this particular patient population by a population-based retrospective cohort study with a follow-up period up to 16 years. Univariate and multivariate Cox regression analyses were used for the risk evaluation and the results were presented as crude and adjusted hazard ratios (HRs). Overall, we enrolled 557 AS patients with endophthalmitis as the study cohort and selected another 2228 matched AS patients without endophthalmitis as the comparison cohort. Comparing the comparison cohort, the study cohort showed a significantly higher overall AMI incidence rate with an adjusted HR of 1.631 (p < 0.001). In conclusion, endophthalmitis increased the risk of AMI in AS patients after adjusting for possible clinical confounders. Special attention and work-up are required for physicians when encountering a history of endophthalmitis in these special patient populations, especially when they are comorbid with other potential CV risk factors.
A Standardized Operative Protocol for Fixation of Proximal Humeral Fractures Using a Locking Plate to Minimize Surgery-Related Complications
Authors: Kwisda Sebastian , Imiolczyk Jan-Philipp , Imiolczyk Tankred , Werth Magdalena , Scheibel Markus
Published: February 2023

The current literature suggests that up to 55% of complications after plate osteosynthesis treatment for patients with proximal humerus fractures are attributed to the surgical procedure. The hypothesis of this study was that a standardized surgical protocol would minimize surgery-related adverse events. This prospective cohort study included 50 patients with a mean age of 63.2 (range 28–92) years treated by one single surgeon using a previously published standardized surgical protocol. Clinical and radiological follow-up examinations were conducted for up to 24 months using Constant–Murley Score (CS), Subjective Shoulder Value (SSV) and radiographs in true anteroposterior, axial and y-view. Finally, CS was 73.9 (standard deviation [SD]: 14.0) points (89% compared to the uninjured shoulder), and SSV was 83.3% (SD: 16.7) at two years of follow-up. Postoperative radiologic evaluation revealed no primary surgical-related or soft-tissue-related complications (0%). The main complications were secondary, biological complications (20%), largely represented by avascular necrosis (8%). Eight patients underwent revision surgery, mainly for implant removal. In addition, a total of four patients were revised using a hemiarthroplasty (n = 2), reverse shoulder arthroplasty (n = 1) or re-osteosynthesis. The use of our standardized surgical technique on proximal humerus fractures improves fixation with regard to primary stability and prevents primary, surgical-technique-related complications. The subjective grading of a high level of difficulty surgery was associated with more complications.
Machine Learning Predictive Models for Evaluating Risk Factors Affecting Sperm Count: Predictions Based on Health Screening Indicators
Authors: Huang Hung-Hsiang , Hsieh Shang-Ju , Chen Ming-Shu , Jhou Mao-Jhen , Liu Tzu-Chi , Shen Hsiang-Li , Yang Chih-Te , Hung Chung-Chih , Yu Ya-Yen , Lu Chi-Jie
Published: February 2023

In many countries, especially developed nations, the fertility rate and birth rate have continually declined. Taiwan’s fertility rate has paralleled this trend and reached its nadir in 2022. Therefore, the government uses many strategies to encourage more married couples to have children. However, couples marrying at an older age may have declining physical status, as well as hypertension and other metabolic syndrome symptoms, in addition to possibly being overweight, which have been the focus of the studies for their influences on male and female gamete quality. Many previous studies based on infertile people are not truly representative of the general population. This study proposed a framework using five machine learning (ML) predictive algorithms—random forest, stochastic gradient boosting, least absolute shrinkage and selection operator regression, ridge regression, and extreme gradient boosting—to identify the major risk factors affecting male sperm count based on a major health screening database in Taiwan. Unlike traditional multiple linear regression, ML algorithms do not need statistical assumptions and can capture non-linear relationships or complex interactions between dependent and independent variables to generate promising performance. We analyzed annual health screening data of 1375 males from 2010 to 2017, including data on health screening indicators, sourced from the MJ Group, a major health screening center in Taiwan. The symmetric mean absolute percentage error, relative absolute error, root relative squared error, and root mean squared error were used as performance evaluation metrics. Our results show that sleep time (ST), alpha-fetoprotein (AFP), body fat (BF), systolic blood pressure (SBP), and blood urea nitrogen (BUN) are the top five risk factors associated with sperm count. ST is a known risk factor influencing reproductive hormone balance, which can affect spermatogenesis and final sperm count. BF and SBP are risk factors associated with metabolic syndrome, another known risk factor of altered male reproductive hormone systems. However, AFP has not been the focus of previous studies on male fertility or semen quality. BUN, the index for kidney function, is also identified as a risk factor by our established ML model. Our results support previous findings that metabolic syndrome has negative impacts on sperm count and semen quality. Sleep duration also has an impact on sperm generation in the testes. AFP and BUN are two novel risk factors linked to sperm counts. These findings could help healthcare personnel and law makers create strategies for creating environments to increase the country’s fertility rate. This study should also be of value to follow-up research.
PCOS in Adolescents—Ongoing Riddles in Diagnosis and Treatment
Authors: Meczekalski Blazej , Niwczyk Olga , Kostrzak Anna , Maciejewska-Jeske Marzena , Bala Gregory , Szeliga Anna
Published: February 2023

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. A diagnosis of PCOS is established when a patient exhibits two of three Rotterdam criteria: oligoovulation or anovulation, excess androgen activity, and polycystic ovarian morphology. The pathogenesis of PCOS, as it affects adolescents, is often discussed in terms of a “two-hit” theory. This refers to a stepwise process in which the first “hit” is an inborn congenitally programmed predisposition, while the second “hit” arises from a provocative factor such as insulin resistance. The dynamic physiological and anatomical changes which occur in puberty make for a challenging diagnosis in this group of patients. It is important to be mindful of the physiological particularities in adolescence which often mimic the symptoms of PCOS. In their first-year post-menarche, approximately 75% of menstruating adolescents report their cycle to last between 21–45 days. Recent studies have shown that regular menstrual cyclicity is only achieved within 2–3 years post-menarche. Anovulation, as a crucial diagnostic element for PCOS, features in about half of early-post-menarchal adolescents. Hirsutism and acne are the most common clinical manifestations of hyperandrogenism, and mild features are developed by most adolescents as a result of elevated androgen levels. Distinguishing between a pathological sign and normal features of maturation is often difficult. A polycystic ovarian morphology (PCOM) through ultrasound has been found in up to 40%, 35%, and 33.3% of patients when assessed at 2, 3, and 4 years, respectively, after menarche. PCOM in adolescence is not associated with future abnormalities in ovulatory rate or menstrual cycle duration. For this reason, international guidelines recommend against the use of pelvic ultrasound until 8 years post-menarche. The primary aim of management is focused mainly on improving hormonal and metabolic status, the prevention of future comorbid complications, and generally improving the overall quality of life in young women with PCOS. Considerable controversy surrounds the choice of optimal pharmacological treatment to address PCOS in adolescents. Reliable studies, which include this sub-section of the population, are very limited. There is a lack of robust and reliable trials in the literature addressing the use of combined oral contraceptives. Further work needs to be undertaken in order to provide safe and effective care to the adolescent population in this regard.
The Study of a Validated Assessment Scale for a Localized Submental Fat Volume
Authors: Oh Joon-Seok , Choi Jinil , Choi Jong-Woo , Lew Dae-Hyun , Roh Tai-Suk , Song Seung-Yong , Kim Young-Seok , Park Hojin , Youn Sang-Woong , Kang Shinhyuk , Park Jihyun , Oh Jeongseok , Heo Chan-Yeong
Published: February 2023

Background: This aim of this study was to develop an objective tool for rating submental fat applied to Koreans. Methods: The study was conducted between April 2019 and October 2019. A total of 92 subjects were enrolled in the study. Clinical photos of the subjects were categorized using validated CR-SMFRS by three plastic surgeons and one dermatologist. The categorized photos were then shown to six different plastic surgeons for evaluation. Results: The Cohen’s kappa value for the six raters were 0.830, 0.742, 0.703, 0.907, 0.862, and 0.793 with statistical significance (p < 0.001). ICC value was between 0.860 and 0.966 (p < 0.001). Since the Cohen’s value and ICC were above 0.6 for all raters, the ratings performed by all six raters were used in the analysis. The ICC values between raters were between 0.899 and 0.902. Conclusions: We came up with a set of reference photos that can be used for submental fat rating scale applicable to Korean subjects. Level of Evidence: II.
Marine Gas Hydrate: Geological Characterization, Resource Potential, Exploration, and Development
Authors: Lei Liang , Hu Gaowei
Published: February 2023

Natural gas hydrate is critical for its tremendous potential to impact the energy supply field, accelerate global warming if methane reaches the atmosphere, and affect the safety of deep-sea oil and gas production [...]
Arsenic Adsorption and Toxicity Reduction of An Exopolysaccharide Produced by Bacillus licheniformis B3-15 of Shallow Hydrothermal Vent Origin
Authors: Spanò Antonio , Zammuto Vincenzo , Macrì Angela , Agostino Eleonora , Nicolò Marco Sebastiano , Scala Angela , Trombetta Domenico , Smeriglio Antonella , Ingegneri Mariarosaria , Caccamo Maria Teresa , Magazù Salvatore , Martinez Miguel , Leon Carla Geraldine , Guglielmino Salvatore Pietro Paolo , Gugliandolo Concetta
Published: February 2023

Exopolysaccharide (EPS) production represents an adaptive strategy developed by extremophiles to cope with environmental stresses. The EPS-producing Bacillus licheniformis B3-15, of shallow marine vent origin (Vulcano Island, Italy), was previously reported as tolerant to arsenate (AsV). In this study, we evaluated: (i) the increasing production of EPS by Bacillus licheniformis B3-15 in the novel SG17 medium; (ii) the arsenic absorption capacity of the EPS by mass spectroscopy; (iii) the functional groups of EPS interacting with As by ATR-FTIR spectroscopy; and (iv) the ability of EPS to prevent arsenic toxicity by the bioluminescent assay. The EPS yield (240 mg L−1) was 45% higher than previously reported. The EPS was mainly constituted of disaccharide repeating units with a manno-pyranosidic configuration and low protein content, attributed to the poly-gamma glutamic acid component as evidenced by NMR analysis. ATR-FTIR spectra indicated that the functional groups of the EPS (O–H, C=O, C–O and C=C and N–O) were involved in the adsorption of the arsenic cations, with greater interactions between EPS and arsenate (AsV) than arsenite (AsIII). Consequently, the EPS at increasing concentration (100 and 300 µg mL−1) adsorbed AsV more efficiently (20.5% and 34.5%) than AsIII (0.7% and 1.8%). The bioluminescence assay showed that the EPS was not toxic, and its addition reduced the toxicity of both As forms by more than twofold. The crude EPS B3-15 could be used in arsenic bioremediation as a possible eco-friendly alternative to other physical or chemical methods.
Advances in Sedimentology and Coastal and Marine Geology
Authors: Aiello Gemma
Published: February 2023

The Special Issue “Advances in Sedimentology and Coastal and Marine Geology” has collected significant research articles advancing the state of the art of the corresponding sub-disciplines [...]
Analysis of Management Models of Regional Ports in the Republic of Croatia
Authors: Glavinović Roko , Vukić Luka , Peronja Ivan
Published: February 2023

Seaports play a crucial role in the transportation and logistics chain, and their development and optimization require significant investments in infrastructure, superstructure, human resources, and management. To ensure the efficiency and effectiveness of these investments, it is essential to implement a well-designed port management model. This model should be based on the criteria used to guide the selection process and ensure that the chosen model aligns with the needs and objectives of the port, stakeholders, and community. This study aims to determine the optimal criteria and management model for the regional seaports in the Republic of Croatia. Port management experts’ opinions were obtained through a questionnaire, and data were analyzed using the AHP and fuzzy AHP methods. The results showed that the criterion of functionality is optimal for choosing the appropriate management model, while the most favorable management model is the coordinated decentralized model. The results obtained by both methods were the same. Different criteria and management models, with similarities and differences between the obtained results and the provisions of the National Development Plan of Ports Open to Public Transport of Regional and Local Significance, are discussed and highlighted.
Classification of Hull Blocks of Ships Using CNN with Multi-View Image Set from 3D CAD Data
Authors: Chon Haemyung , Oh Daekyun , Noh Jackyou
Published: February 2023

In order to proceed with shipbuilding scheduling involving hundreds of hull blocks of ships, it is important to mark the locations of the hull blocks with the correct block identification number. Incorrect information about the locations and the identification numbers of hull blocks causes disruption in the shipbuilding scheduling process of the shipyard. Therefore, it is necessary to have a system for tracking the locations and identification numbers of hull blocks in order to avoid time loss due to incorrectly identified blocks. This paper proposes a method to mark the identification numbers, which are necessary for the tracking system of hull blocks. In order to do this, 3 CNN (convolutional neural network) models, VGG-19, Resnet-152V2, and Densenet-201, are used to classify the hull blocks. A set of multi-view images acquired from 3D CAD data are used as training data to obtain a trained CNN model, and images from 3D printer-printed hull block models are used for the test of the trained CNN model. The datasets used for training and prediction are Non-Thr and Thr datasets, that each included both binarized and non-binarized datasets. As a result of end-to-end classification experiments with Non-Thr datasets, the highest prediction accuracy was 0.68 with Densenet-201. A total of 4050 experimental conditions were constructed by combining the threadhold of the Thr training and testing dataset. As a result of experiments with Thr datasets, the highest prediction accuracy of 0.96 was acquired with Resnet-152V2, which was trained with a threshold of 72 and predicted with a threshold of 50. In conclusion, the classification of ship hull blocks using a CNN model with binarized datasets of 3D CAD data is more effective than that using a CNN model with non-binarized datasets.
Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches
Authors: Mangogna Alessandro , Munari Giada , Pepe Francesco , Maffii Edoardo , Giampaolino Pierluigi , Ricci Giuseppe , Fassan Matteo , Malapelle Umberto , Biffi Stefania
Published: February 2023

The inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway is defined as homologous recombination deficiency (HRD). This molecular phenotype represents a positive predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors and platinum-based chemotherapy in ovarian cancers. However, HRD is a complex genomic signature, and different methods of analysis have been developed to introduce HRD testing in the clinical setting. This review describes the technical aspects and challenges related to HRD testing in ovarian cancer and outlines the potential pitfalls and challenges that can be encountered in HRD diagnostics.
A GIS-Based Kinematic Analysis for Jointed Rock Slope Stability: An Application to Himalayan Slopes
Authors: Kundu Jagadish , Sarkar Kripamoy , Ghaderpour Ebrahim , Scarascia Mugnozza Gabriele , Mazzanti Paolo
Published: February 2023

GIS-based kinematic stability analysis in rock slopes is a rare practice in geological engineering despite its immense potential to delineate unstable zones in a mountainous region. In this article, we have used a GIS-based modified technique to assess the efficiency of kinematic analysis in predicting shallow landslides in the rock slopes of the Himalayan mountains on a regional scale. The limited use of this technique is primarily due to the complexities involved in its practical application. To make this technique more effective and convenient usability, we present modified methods and a new application, ‘GISMR’, that works with the aid of GIS software for the determination of kinematic susceptibility. A modified kinematic analysis method was implemented to define the stability in terms of failure susceptibility on a scale of 0 to 100 rather than a conservative result, such as failure or non-failure. We also present another functionality of the GISMR that provides optimised slope angles over a region. This functionality could aid the decision-making process when selecting a suitable location for a road path or other engineering constructions that are impacted by unstable mountain slopes. The applicability of this new method was demonstrated in a rock failure-prone region in the mountains of the Indian Himalayas. The outcomes delineate the unstable slopes in the region, which are intersected by a strategic National Highway 05 and have a long history of landslide-related hazards. It was found that 9.61% of the area is susceptible to failure. However, 2.28% is classified as a low susceptible region, and 2.58% of the area is very-low susceptible. The regions with moderately high, high, and very-high susceptibility cover 2.78%, 1.49%, and 0.46% of the whole area, respectively. The results were evaluated by receiver operating characteristic curve and a frequency ratio method to represent the association between kinematic susceptibility and the mass movement inventory in the area. It is concluded that kinematic susceptibility has a strong relationship with landslide activity in the rock slopes of the Himalayan region.
Association of Circulating Neutrophils with Relative Volume of Lipid-Rich Necrotic Core of Coronary Plaques in Stable Patients: A Substudy of SMARTool European Project
Authors: Sbrana Silverio , Cecchettini Antonella , Bastiani Luca , Mazzone Annamaria , Vozzi Federico , Caselli Chiara , Neglia Danilo , Clemente Alberto , Scholte Arthur J. H. A. , Parodi Oberdan , Pelosi Gualtiero , Rocchiccioli Silvia
Published: February 2023

Background and Aims: Coronary atherosclerosis is a chronic non-resolving inflammatory process wherein the interaction of innate immune cells and platelets plays a major role. Circulating neutrophils, in particular, adhere to the activated endothelium and migrate into the vascular wall, promoting monocyte recruitment and influencing plaque phenotype and stability at all stages of its evolution. We aimed to evaluate, by flow cytometry, if blood neutrophil number and phenotype—including their phenotypic relationships with platelets, monocytes and lymphocytes—have an association with lipid-rich necrotic core volume (LRNCV), a generic index of coronary plaque vulnerability, in a group of stable patients with chronic coronary syndrome (CCS). Methods: In 55 patients, (68.53 ± 1.07 years of age, mean ± SEM; 71% male), the total LRNCV in each subject was assessed by a quantitative analysis of all coronary plaques detected by computed tomography coronary angiography (CTCA) and was normalized to the total plaque volume. The expression of CD14, CD16, CD18, CD11b, HLA-DR, CD163, CCR2, CCR5, CX3CR1, CXCR4 and CD41a cell surface markers was quantified by flow cytometry. Adhesion molecules, cytokines and chemokines, as well as MMP9 plasma levels, were measured by ELISA. Results: On a per-patient basis, LRNCV values were positively associated, by a multiple regression analysis, with the neutrophil count (n°/µL) (p = 0.02), neutrophil/lymphocyte ratio (p = 0.007), neutrophil/platelet ratio (p = 0.01), neutrophil RFI CD11b expression (p = 0.02) and neutrophil–platelet adhesion index (p = 0.01). Significantly positive multiple regression associations of LRNCV values with phenotypic ratios between neutrophil RFI CD11b expression and several lymphocyte and monocyte surface markers were also observed. In the bivariate correlation analysis, a significantly positive association was found between RFI values of neutrophil–CD41a+ complexes and neutrophil RFI CD11b expression (p < 0.0001). Conclusions: These preliminary findings suggest that a sustained increase in circulating neutrophils, together with the up-regulation of the integrin/activation membrane neutrophil marker CD11b may contribute, through the progressive intra-plaque accumulation of necrotic/apoptotic cells exceeding the efferocytosis/anti-inflammatory capacity of infiltrating macrophages and lymphocytes, to the relative enlargement of the lipid-rich necrotic core volume of coronary plaques in stable CAD patients, thus increasing their individual risk of acute complication.
Transcutaneous Neuromodulation for Constipation and Fecal Incontinence in Children: A Systematic Review and Meta-Analysis
Authors: Correia Ronny Rodrigues , Gameiro Luis Felipe Orsi , Trevisane Nathalia Grion , Bertanha Matheus , Ortolan Erika Veruska Paiva , Lourenção Pedro Luiz Toledo de Arruda
Published: February 2023

Introduction: Constipation is a disorder with a multifactorial origin. Constipation has a varied clinical presentation, including infrequent defecation of bulky stools and episodes of retentive fecal incontinence. Neuromodulation has been used to treat many health problems, with promising results. Objective: To conduct a systematic review of randomized clinical trials based on the effects of transcutaneous neuromodulation in treating constipation and retentive fecal incontinence in children and adolescents. Methods: A systematic review of randomized clinical trials was performed. Medline (PubMed), PEDro, SciELO, Cochrane (CENTRAL), Embase, and Scopus databases were searched from March 2000 to August 2022. We included clinical trials evaluating transcutaneous neuromodulation in children with constipation and fecal incontinence compared or associated with other types of treatment. Two reviewers independently selected relevant studies, assessed the methodological quality, and extracted the data. Results: Three studies with 164 participants were included in this review. Two meta-analyses were generated based on these studies. These analyses revealed that transcutaneous neuromodulation is an effective adjuvant treatment modality that improves children’s constipation and retentive fecal incontinence. The methodological quality of the included studies was classified as high based on the assessment of the quality of evidence, with a high degree of confidence based on the GRADE system. Conclusions: Transcutaneous neuromodulation is an effective adjuvant treatment modality for children with constipation and retentive fecal incontinence.
Characterization of Stable Pyrazole Derivatives of Curcumin with Improved Cytotoxicity on Osteosarcoma Cell Lines
Authors: Feriotto Giordana , Rondanin Riccardo , Marchetti Paolo , Tagliati Federico , Beninati Simone , Tabolacci Claudio , Grusi Elisa , Aguzzi Serena , Mischiati Carlo
Published: February 2023

Curcumin (CUR) is a natural molecule that is unstable due to the presence of a bis-ketone. To obtain more stable derivatives in biological fluids, the bis-ketone was replaced with pyrazole or O-substituted oximes. Their stability in solution was studied by UV–visible spectrophotometry. The effects on proliferation were studied by MTT assay and/or clonogenicity assay. Induction of apoptosis was evaluated by annexin V staining and Western blot analysis. The bioavailability was obtained from the analysis of the molecular chemical–physical characteristics. The replacement of the bis-ketone with a pyrazole ring or O-substituted oximes improved the stability of all the CUR-derivative molecules. These derivatives were more stable than CUR in solution and were generally cytotoxic on a panel of cancer cell lines tested, and they promoted caspase-dependent apoptosis. Derivative 1 was the most potent in the osteosarcoma (OS) lines. With respect to CUR, this derivative showed cytotoxicity at least three times higher in the MTT assay. In addition, in the clonogenic assay, 1 maintained the activity in conditions of long treatment presumably by virtue of its improved stability in biological fluids. Notably, 1 should have improved chemical–physical characteristics of bioavailability with respect to CUR, which should allow for reaching higher blood levels than those observed in the CUR trials. In conclusion, 1 should be considered in future clinical studies on the treatment of OS, either alone or in combination with other medications currently in use.
Russian Registry of Idiopathic Pulmonary Fibrosis: Clinical Features, Treatment Management, and Outcomes
Authors: Chikina Svetlana , Cherniak Alexander , Merzhoeva Zamira , Tyurin Igor , Trushenko Natalia , Proshkina Anna , Ataman Kirill , Avdeev Sergey
Published: February 2023

A registry of patients with idiopathic pulmonary fibrosis (IPF) was founded in Russia in 2016. The aim of this study was to analyze the demographic, clinical, functional, radiological, and morphological data of the patients included in this registry. Methods. This was a prospective multicenter, observational, non-interventional study. Patients’ risk factors, demographics, clinical data, results of high-resolution computed tomography (HRCT) of the chest and pulmonary function testing, and lung tissue biopsy findings were analyzed. We also analyzed the exercise tolerance (6-min walking test) of patients, serological markers of systemic connective tissue diseases, treatment, clinical course, and outcomes of the disease. Multidisciplinary discussion (MDD) was used as needed. Results. One thousand three hundred and fifty-three patients were included in the registry from 2016 to 2020. The mean age was 64.4 ± 10.7 years, most patients were active smokers or ex-smokers. Antifibrotic therapy was administered to 90 of 948 patients (9.5%). Since starting the registry in 2016, the incidences of IPF have increased and the time period from manifestation of the disease to making the diagnosis has shortened, the number of patients on antifibrotic therapy has increased and the number of patients taking systemic steroids decreased. Conclusion. The registry of patients with IPF was helpful to improve IPF diagnosis and to implement antifibrotic agents in clinical practice. Further analysis of the clinical course and prognostic markers of IPF in the Russian population is needed. An analysis of the long-term efficacy of antifibrotic therapy in this population is also important.
Exact Model Order Reduction for the Full-System Finite Element Solution of Thermal Elastohydrodynamic Lubrication Problems
Authors: Mounayer Jad , Habchi Wassim
Published: February 2023

The derivation of fast, reliable, and accurate modeling procedures for the solution of thermal elastohydrodynamic lubrication problems is a topic of significant interest in the Tribology community. In this paper, a novel model order reduction technique is introduced for the analysis of thermal elastohydrodynamic lubrication problems. The method uses static condensation to reduce the size of the linear elasticity part within the overall matrix system, followed by a splitting algorithm to avoid the burden of solving a semi-dense matrix system. The results reveal the exactness of the proposed methodology, which does not introduce any additional model-reduction approximations to the overall solution. They also reveal the reduction in computational times, which is in the order of 10–20% for line contacts, while it is in excess of 50% for circular contacts. The robustness of the proposed method is displayed by using it to model some relatively highly loaded contacts whose numerical solution is known to be rather challenging.
(Z)-3-(Dicyanomethylene)-4-((5-fluoro-3,3-dimethyl-1-(3-phenylpropyl)-3H-indol-1-ium-2-yl) methylene)-2-(((E)-5-fluoro-3,3-dimethyl-1-(3-phenylpropyl)indolin-2-ylidene)methyl) cyclobut-1-en-1-olate
Authors: Casa Stefanie , Ersoy Ozmen Guliz , Henary Maged
Published: February 2023

Recent literature on this topic highlights the significance of adding malononitrile moiety and halogen substituents to the squaraine scaffold to create redshifted fluorophores into the near-infrared optical region. Herein, a redshifted hydrophobic squaraine dye is synthesized via a three-step pathway. The reported dye is characterized by spectroscopic techniques, such as 1H NMR, 19F NMR, 13C NMR, and high-resolution mass spectroscopy. Optical properties are also reported using absorbance and fluorescence studies. The hydrophobicity of the dye was studied with absorbance and fluorescence spectroscopy in water–methanol mixtures and showed J-aggregates as the water concentration increased. Density functional theory calculations were conducted to assess its electron delocalization as well as observe the three-dimensional geometry of the dye as a result of the dicyanomethylene modification and the two bulky phenyl groups.
Prediction of Chloride Diffusion Coefficient in Concrete Modified with Supplementary Cementitious Materials Using Machine Learning Algorithms
Authors: Al Fuhaid Abdulrahman Fahad , Alanazi Hani
Published: February 2023

The chloride diffusion coefficient (Dcl) is one of the most important characteristics of concrete durability. This study aimed to develop a prediction model for the Dcl of concrete incorporating supplemental cementitious material. The datasets of concrete containing supplemental cementitious materials (SCMs) such as tricalcium aluminate (C3A), ground granulated blast furnace slag (GGBFS), and fly ash were used in developing the model. Five machine learning (ML) algorithms including adaptive neuro-fuzzy inference system (ANFIS), artificial neural network (ANN), support vector machine (SVM), and extreme learning machine (ELM) were used in the model development. The performance of the developed models was tested using five evaluation metrics, namely, normalized reference index (RI), coefficient of determination (R2), mean absolute error (MAE), and root mean square error (RMSE). The SVM models demonstrated the highest prediction accuracy with R2 values of 0.955 and 0.951 at the training and testing stage, respectively. The prediction accuracy of the machine learning (ML) algorithm was checked using the Taylor diagram and Boxplot, which confirmed that SVM is the best ML algorithm for estimating Dcl, thus, helpful in establishing reliable tools in concrete durability design.
Hardness Distribution of Al2050 Parts Fabricated Using Additive Friction Stir Deposition
Authors: Ghadimi Hamed , Ding Huan , Emanet Selami , Talachian Mojtaba , Cox Chase , Eller Michael , Guo Shengmin
Published: February 2023

The solid-state additive friction stir deposition (AFSD) process is a layer-by-layer metal 3D-printing technology. In this study, AFSD is used to fabricate Al–Cu–Li 2050 alloy parts. The hardness values for various regions of the as-deposited built parts are measured, and the results are contrasted with those of the feedstock material. The as-fabricated Al2050 parts are found to have a unique hardness distribution due to the location-specific variations in the processing temperature profile. The XRD results indicate the presence of the secondary phases in the deposited parts, and EDS mapping confirms the formation of detectable alloying particles in the as-deposited Al2050 matrix. The AFSD thermal–mechanical process causes the unique hardness distribution and the reduced microhardness level in the AFSD components, in contrast to those of the feedstock material.
Sound Velocity and Equation of State of Ballistic Gelatin by Brillouin Scattering
Authors: Ahart Muhtar , Hemley Russell J.
Published: February 2023

Brillouin scattering spectroscopy with diamond anvil cells was used by measuring the pressure dependence of the sound-relevant polymer material, glass-forming liquid, and H2O (water and ice VII) velocities of the material from ambient pressure to 12 GPa at room temperature. Measurements of 20%, 10%, and 4% gelatin solutions were performed. For comparison purposes, we also measured the pressure dependence of the sound velocity of animal tissue up to 10 GPa. We analyzed the Brillouin data using the Tait and Vinet equations of state. We discussed the possible influence of frequency dispersion on bulk modulus at low pressure. We compared the elastic moduli obtained for gelatin to those of several other polymers.
Sustainable Composites from Nature to Construction: Hemp and Linseed Reinforced Biocomposites Based on Bio-Based Epoxy Resins
Authors: Vidal Julio , Ponce David , Mija Alice , Rymarczyk Monika , Castell Pere
Published: February 2023

The present manuscript describes the use of natural fibers as natural and sustainable reinforcement agents for advanced bio-based composite materials for strategic sectors, for example, the construction sector. The characterization carried out shows the potential of both natural hemp and linseed fibers, as well as their composites, which can be used as insulation materials because their thermal conductivity properties can be compared with those observed in typical construction materials such as pine wood. Nevertheless, linseed composites show better mechanical performance and hemp has higher fire resistance. It has been demonstrated that these natural fibers share similar properties; on the other hand, each of them should be used for a specific purpose. The work also evaluates the use of bio matrixes in composites, demonstrating their feasibility and how they impact the final material’s properties. The proposed bio-resin enhances fire resistance and decreases the water absorption capacity of the natural fibers, enabling the use of composites as a final product in the construction sector. Therefore, it has been demonstrated that it is possible to manufacture a biocomposite with non-woven natural fibers. In fact, for properties such as thermal conductivity, it is capable of competing with current materials. Proving that biomaterials are a suitable solution for developing sustainable products, fulfilling the requirements of the end-user applications, as it has been demonstrated in this research with the non-woven fibers for the non-structural components.
Manufacturing of Metal–Diamond Composites with High-Strength CoCrCuxFeNi High-Entropy Alloy Used as a Binder
Authors: Loginov Pavel A. , Fedotov Alexander D. , Mukanov Samat K. , Manakova Olga S. , Zaitsev Alexander A. , Akhmetov Amankeldy S. , Rupasov Sergey I. , Levashov Evgeny A.
Published: February 2023

This paper focuses on the study of the structure and mechanical properties of CoCrCuxFeNi high-entropy alloys and their adhesion to single diamond crystals. CoCrCuxFeNi alloys were manufactured by the powder metallurgy route, specifically via mechanical alloying of elemental powders, followed by hot pressing. The addition of copper led to the formation of a dual-phase FCC + FCC2 structure. The CoCrCu0.5FeNi alloy exhibited the highest ultimate tensile strength (1080 MPa). Reductions in the ductility of the CoCrCuxFeNi HEAs and the tendency for brittle fracture behavior were observed at high copper concentrations. The equiatomic alloys CoCrFeNi and CoCrCuFeNi demonstrated high adhesion strength to single diamond crystals. The diamond surface at the fracture of the composites having the CoCrFeNi matrix had chromium-rich metal matrix regions, thus indicating that chromium carbide, responsible for adhesion, was formed at the composite–diamond interface. Copper-rich areas were detected on the diamond surface within the composites having the CoCrCuFeNi matrix due to the predominant precipitation of the FCC2 phase at the interfaces or the crack propagation along the FCC/FCC2 interface, resulting in the exposure of the Cu-rich FCC2 phase on the surface.
Refractive Index Dependence of Fluorescence Enhancement in a Nanostructured Plasmonic Grating
Authors: Angelini Margherita , Manobianco Eliana , Pellacani Paola , Floris Francesco , Marabelli Franco
Published: February 2023

Plasmonic gratings are attracting huge interest in the context of realizing sensors based on surface-enhanced fluorescence. The grating features control the plasmonic modes and consequently have a strong effect on the fluorescence response. Within this framework, we focused on the use of a buffer solution flowing across the grating active surface to mimic a real measurement. The refractive index of the surrounding medium is therefore altered, with a consequent modification of the resonance conditions. The result is a shift in the spectral features of the fluorescence emission accompanied by a reshaping of the fluorescence emission in terms of spectral weight and direction.
Formation Pathways of Lath-Shaped WO3 Nanosheets and Elemental W Nanoparticles from Heating of WO3 Nanocrystals Studied via In Situ TEM
Authors: Chen Xiaodan , van Huis Marijn A.
Published: February 2023

WO3 is a versatile material occurring in many polymorphs, and is used in nanostructured form in many applications, including photocatalysis, gas sensing, and energy storage. We investigated the thermal evolution of cubic-phase nanocrystals with a size range of 5–25 nm by means of in situ heating in the transmission electron microscope (TEM), and found distinct pathways for the formation of either 2D WO3 nanosheets or elemental W nanoparticles, depending on the initial concentration of deposited WO3 nanoparticles. These pristine particles were stable up to 600 °C, after which coalescence and fusion of the nanocrystals were observed. Typically, the nanocrystals transformed into faceted nanocrystals of elemental body-centered-cubic W after annealing to 900 °C. However, in areas where the concentration of dropcast WO3 nanoparticles was high, at a temperature of 900 °C, considerably larger lath-shaped nanosheets (extending for hundreds of nanometers in length and up to 100 nm in width) were formed that are concluded to be in monoclinic WO3 or WO2.7 phases. These lath-shaped 2D particles, which often curled up from their sides into folded 2D nanosheets, are most likely formed from the smaller nanoparticles through a solid–vapor–solid growth mechanism. The findings of the in situ experiments were confirmed by ex situ experiments performed in a high-vacuum chamber.
GHz—THz Dielectric Properties of Flexible Matrix-Embedded BTO Nanoparticles
Authors: Mihai Laura , Caruntu Gabriel , Rotaru Aurelian , Caruntu Daniela , Mykhailovych Vasyl , Ciomaga Cristina Elena , Horchidan Nadejda , Stancalie Andrei , Marcu Aurelian
Published: February 2023

BaTiO3 (BTO) nanoparticles produced by wet chemistry methods were embedded in several types of flexible materials in order to fabricate flexible electronic devices. Starting from the produced nanoparticle dielectric properties, flexible material dielectric properties were tested for high electromagnetic frequencies (30 GHz–2 THz) using time domain spectroscopy. Dielectric performances of the different materials obtained with variable nanoparticle concentrations up to 40 wt.%, embedded in, gelatin, epoxy, and styrene-butadiene were compared at several working temperatures between 0 °C and 120 °C. Beside the general trend of ε′ decrease with temperature and loses increase with the operating frequency, we were able to identify few matrix dependent optimal nanoparticle concentrations. The best composite performances were achieved by the BTO-SBS matrix, with filler concentration of 2 wt.%, where the losses have been of 1.5%, followed by BTO-gelatin matrix, with filler concentration of 40 wt.%, with higher losses percent of almost 10% for THz frequencies.
GO-Enabled Bacterial Cellulose Membranes by Multistep, In Situ Loading: Effect of Bacterial Strain and Loading Pattern on Nanocomposite Properties
Authors: Gabryś Tobiasz , Fryczkowska Beata , Jančič Urška , Trček Janja , Gorgieva Selestina
Published: February 2023

This paper presents the results of research on the preparation and properties of GO/BC nanocomposite from bacterial cellulose (BC) modified with graphene oxide (GO) using the in situ method. Two bacterial strains were used for the biosynthesis of the BC: Komagataeibacter intermedius LMG 18909 and Komagataeibacter sucrofermentans LMG 18788. A simple biosynthesis method was developed, where GO water dispersion was added to reinforced acetic acid-ethanol (RAE) medium at concentrations of 10 ppm, 25 ppm, and 50 ppm at 24 h and 48 h intervals. As a result, a GO/BC nanocomposite membrane was obtained, characterized by tensile strength greater by 150% as compared with the pure BC (̴ 50 MPa) and lower volume resistivity of ~4 ∙ 109 Ω × cm. Moreover, GO addition increases membrane thickness up to ~10% and affects higher mass production, especially with low GO concentration. All of this may indicate the possibility of using GO/BC membranes in fuel cell applications.
Mechanochemical Activation of Superradiance in Paramagnetic Polymer Composites
Authors: Aleksandrov Aleksey I. , Shevchenko Vitaliy G.
Published: February 2023

The review examines the effect of radio-frequency superradiance during pulsed mechanochemical activation of polymer composites under high pressure. Mechanochemical activation is implemented in three modes: (a) rheological explosion of polymer composite under rapid uniaxial compression, when an elastic wave pulse occurs in a polymer composite sample and implements the physico-chemical transformations leading to the occurrence of a superradiance pulse; (b) parametric mode, when an elastic wave pulse is introduced from the outside through a waveguide into a composite sample; (c) the mode of rapid pressure release, which also leads to the occurrence of a superradiance pulse. Paramagnetic polymer composites—namely polystyrene–binuclear clusters Co(QH)2–O–Co(QH)2 or Mn(QH)2–O–Mn(QH)2, where QH is a ligand based on QH2–3,6-di-tert-butylpyrocatechin)—are considered as objects implementing such processes. These binuclear clusters exhibit the Dzyaloshinskii–Moriya effect, and polymer composites based on them exhibit multiferroic properties. A composite of a molecular magnet in polystyrene matrix (Eu(III)(SQ)3·bipy complex with four unpaired electrons on Eu(III) and on SQ ligands; SQ is 3,6-di-tert-butylquinolate paramagnetic ligand) is also considered. The binuclear clusters and europium complexes form 2D nano-objects in the polymer matrix with a diameter of 50–100 nm and a thickness of ~ 1–2 nm. The review considers the formalisms of Dicke, Lorentz, Landau–Lifshitz–Blombergen and Havriliak–Negami equations, which make it possible to conduct a time–frequency analysis of these processes, to obtain data on the relaxation processes of spin and charge density in objects responsible for the process of radio-frequency superradiation. It is also shown that the analysis of electron spin resonance data allows us to provide a probable quantum chemical scheme for the implementation of the radio-frequency superradiance process. The phenomenon of superradiation has a great deal of potential in such areas as energy-saving technologies, wireless power transmission and storage devices. The technique of studying fast mechanochemical processes considered in the review allows us to investigate the mechanisms of interaction of magnetic and electrical subsystems in multiferroics and molecular magnets, which expands the scientific base for the creation of new functional materials and enables the solving of related problems of condensed matter physics.