bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the Evolution of “Ren” and “Li” in SikuQuanshu Confucian Classics
Authors: Hu Bo , Xing Fugui , Fan Miaorong , Zhu Tingshao
Published: April 2021

Confucian culture has always been the most glorious component of Chinese culture. Governing the mainstream world of China for more than two millennia, it has cast a profound and long-lasting influence on the way of thinking and cultural-psychological formation of the Chinese people. Confucianism emphasizes caring about others with benevolence and governing a state with ethics, reflecting the importance of moral principles for politics. “Ren” and “Li” are important parts of the core values of Confucianism, so analyzing the differences between them and their evolution is of great significance for further understanding Confucian culture. This paper selected 132 classic Confucian works from SikuQuanshu, a large collection of books compiled during the Qianlong’s reign of the Qing Dynasty (1636–1912), to calculate the use of frequency of “Ren” and “Li” in those books by means of big data. Then the data was analyzed to show the development trajectory of “Ren” and “Li” from the Spring and Autumn period (770–476 BC) to the Qing Dynasty, providing a new perspective for the study of Confucian culture. The analysis result shows that from the Spring and Autumn period to the Qing Dynasty, both the frequencies of “Ren” and “Li” record a peak and a bottom: “Ren” has its peak in the Sui and Tang period (581–907) while “Li” reaches its climax in the Wei and Jin period (220–420); both “Ren” and “Li” hit their bottom during the Yuan Dynasty (1279–1368). The average frequency of “Li” is higher than that of “Ren” during most of the time (eight dynasties and periods). In general, “Li” is more frequently referred to in classic Confucian works than “Ren,” especially in those of the pre-Sui and Tang era. The An-Shi Disturbances in the Tang Dynasty may mark an important turning point for the frequencies of “Ren” and “Li” in classic Confucian works.
Protective and Risk Factors for Medical and Nursing Staff Suffering From Psychological Symptoms During COVID-19
Authors: Luo Hailong , Yao Huiqi , Xi Yuandi , Zhang Zhun , Li Jia , Li Jie , Wang Xuewen , Zhong Zhixiong , Lv Yan
Published: April 2021

Background: With the outbreak of the coronavirus disease 2019 (COVID-19) epidemic in China, the general public but also medical staff were confronted with psychological challenges, suffering from the highly infectious and unknown characteristics of COVID-19. In this study, we surveyed psychological symptoms including anxiety, depression, and sleep disorders in medical staff.

Method: A questionnaire star/WeChat link-based survey assessing the Generalized Anxiety Disorder 7-item scale, Patient Health Questionnaire-9 depression, the Insomnia Severity Index, Social Support scales in addition to lifestyle, and income level was conducted and included 8,288 medical staff from 24 provinces in China. Pearson Chi-square and Mann-Whitney U-tests were used to evaluate single risk factors and significant differences in psychological symptoms before and during the outbreak of COVID-19. Binary logistic regression analyses were conducted for the risk factors of anxiety, depression, and sleep disorder symptoms.

Results: Medical staff had a high incidence of psychological symptoms, which was more prominent during the COVID-19 epidemic. Comparatively, females, nurses, first-line department, never exercised, and low income were risk factors for psychological symptoms. Social support including objective support, subjective support, support utility, and regular sports over 3 times per week were protective and manageable elements that could protect from and manage the psychological symptoms of medical staff.

Conclusion: The susceptibility of psychological symptoms among medical staff should be of concern to policymakers and the public in the long-term, and the aggravation of mental health problems of medical staff could be eased by providing adequate social support during and after the COVID-19 outbreak.
E-perceptions and Business ‘Mating’: The Communication Effects of the Relative Width of Males’ Faces in Business Portraits
Authors: van Zeeland Eveline , Henseler Jörg
Published: April 2021

This study investigates the relative impacts of the facial width-to-height ratio (fWHR) on the first impressions business professionals form of business consultants when seeing their photographs on a corporate website or LinkedIn page. By applying conjoint analysis on field experiment data (n = 381), we find that in a zero-acquaintance situation business professionals prefer low-fWHR business consultants. This implies that they prefer a face that communicates trustworthiness to one that communicates success. Further, we have investigated the words that business professionals use to describe their preferred consultant. These approach motivations help practitioners to improve the picture-text alignment. The results underline the necessity to critically assess the pictures and text used on websites and media platforms such as LinkedIn for business purposes, and to see them as a key element of business and self-communication that can be altered in order to improve business ‘mating.’
Influence of Perceived Environmental Quality on the Perceived Restorativeness of Public Spaces
Authors: Ríos-Rodríguez María Luisa , Rosales Christian , Lorenzo Maryurena , Muinos Gabriel , Hernández Bernardo
Published: April 2021

Parks and town squares can play an important role by offering spaces for cognitive restorativeness in urban contexts. Therefore, it is important that these spaces be designed in a way that encourages restorativeness. Indeed, their perceived quality should motivate users to stay and take advantage of them. Yet, it is not clear whether perceptions as to the quality of these spaces is relevant in promoting restorativeness. Thus, the aim of this study is to analyze whether elements of environmental quality perceived by users of public spaces favor restorativeness both in parks and squares. Environmental and social aspects are taken into consideration, since restorative experiences involve cognitive and physiological recovery, as well as a component of interaction with the environment. In this research, 519 users of 32 urban public spaces—town squares and parks—on the island of Tenerife (Spain) participated. Participants evaluated these spaces using four dimensions that focused on spaces’ perceived environmental quality: design of spaces, care of spaces, social interaction, and presence of sensorial elements. Additionally, we evaluated the perceived restorativeness of each space. The results showed that the design of spaces, care of the spaces, social interaction, and presence of sensorial elements explain the variance in perceived restorativeness, although with different weights for parks and squares. We found that perceived quality of a space is a key predictor of its restorativeness. This means that maintaining parks and town squares is a relevant task given that they contribute to reducing cognitive overload, increasing sustainability, and facilitating health care in urban settings.
From Resilience to Burnout in Healthcare Workers During the COVID-19 Emergency: The Role of the Ability to Tolerate Uncertainty
Authors: Di Trani Michela , Mariani Rachele , Ferri Rosa , De Berardinis Daniela , Frigo Maria G.
Published: April 2021

The COVID-19 outbreak has placed extraordinary demands upon healthcare systems worldwide. Italy's hospitals have been among the most severely overwhelmed, and as a result, Italian healthcare workers' (HCWs) well-being has been at risk. The aim of this study is to explore the relationships between dimensions of burnout and various psychological features among Italian healthcare workers (HCWs) during the COVID-19 emergency. A group of 267 HCWs from a hospital in the Lazio Region completed self-administered questionnaires online through Google Forms, including the Maslach Burnout Inventory (MBI), Resilience Scale, and Intolerance of Uncertainty Scale Short Form (IU). Cluster analysis highlighted two opposite burnout risk profiles: low burnout and high-risk burnout. The high-risk group had lower resilience and greater difficulties in tolerating the uncertainty than the low-burnout group. A set of general linear models confirmed that both IU subscales, prospective and inhibition, moderated the relationship between resilience and burnout (specifically in the depersonalization dimension). In conclusion, the results showed that individual levels of resilience and one's ability to tolerate uncertainty have been significant factors in determining the impact of the COVID-19 emergency on HCWs. The use of emotional strategies that allow individuals to stay in a critical situation without the need to control it appears to protect against burnout in these circumstances.
Sociodemographic Correlates and Mental Health Comorbidities in Adolescents With Social Anxiety: The Young-HUNT3 Study, Norway
Authors: Jystad Ingunn , Bjerkeset Ottar , Haugan Tommy , Sund Erik R. , Vaag Jonas
Published: April 2021

Social anxiety is highly prevalent in adolescents and is often associated with great individual suffering and functional impairment. Psychiatric comorbidity is common and further adds to this burden. The purposes of this study were: (1) to describe the occurrence of diagnosed and self-reported social anxiety among 8,199 Norwegian adolescents aged 13–19 years who participated in the population-based Young-HUNT3 study (2006–2008); (2) to examine associations between sociodemographic characteristics and different subgroups of social anxiety; and (3) to describe the psychiatric health comorbidities among adolescents diagnosed with social anxiety disorder (SAD). In total, 388 (5.9%) of the adolescents screened positive for SAD and were invited into a diagnostic interview, performed by professional nurses, using Anxiety Disorders Interview Schedule for DSM IV: child version (ADIS-C) (response rate = 54.6%). A SAD diagnosis was indicated in 106 individuals (50% of the interview subjects), and more than two-thirds of the adolescents diagnosed with SAD had one or more comorbid psychiatric disorders. Higher mean scores of self-reported social anxiety symptoms, poor self-rated health, sleep problems, poor family economic situation, low physical activity, and having sought professional help within the last year were associated with higher odds of being in the screening positive subgroup. Screening positive subjects who did not meet for a diagnostic interview did not differ notably from the rest of the screening positive group in terms of these sociodemographic characteristics. Based on our results and the fact that individuals with social anxiety often fear interview situations, the use of ADIS-C, screening questions and self-reports seem to be sufficient when aiming to identify epidemiologically representative cohorts of adolescents at risk of social anxiety.
Problematic Smartphone and Social Media Use Among Bangladeshi College and University Students Amid COVID-19: The Role of Psychological Well-Being and Pandemic Related Factors
Authors: Islam Md. Saiful , Sujan Md. Safaet Hossain , Tasnim Rafia , Mohona Rashenda Aziz , Ferdous Most. Zannatul , Kamruzzaman Sk , Toma Tanziha Yeasmin , Sakib Md. Nazmus , Pinky Khairrun Nahar , Islam Md. Riad , Siddique Md. Abid Bin , Anter Fahim Shariar , Hossain Alomgir , Hossen Ikram , Sikder Md. Tajuddin , Pontes Halley M.
Published: April 2021

Background: Smartphone and social media use are an integral part of our daily life. Currently, the impact of excessive smartphone and social media use during the COVID-19 pandemic is poorly understood. The present study aimed to investigate problematic smartphone use (PSPU) and problematic social media use (PSMU) among Bangladeshi college and university students during the COVID-19 pandemic.

Methods: A cross-sectional study was carried out involving 5,511 Bangladeshi college and university students (male: 58.9%; mean age: 21.2 years [SD = 1.7]; age range: 18–25) during the social-distancing in the COVID-19 pandemic (July 2020). A self-reported survey containing questions regarding socio-demographic, lifestyle, and home quarantine activities along with four psychometric scales was completed by participants.

Results: The mean scores of PSPU and PSMU were 20.8 ± 6.8 (out of 36) and 14.7 ± 4.8 (out of 30). Based on a hierarchical regression analysis, PSPU and PSMU were positively associated with lower age, poor sleep, social media use, watching television, anxiety, and depression. Additionally, PSMU was linked to being female, living with nuclear family, having urban residence, irregular physical exercise, poor engagement with academic studies, and avoiding earning activities, whilst being male, being married, living with lower-income family, and alcohol consumption were linked to PSMU.

Conclusions: The findings indicate that PSPU and PSMU were linked to poor psychological well-being (i.e., anxiety and depression) and other factors (especially lower age, poor sleep) during the pandemic, further suggesting the need for interventions including virtual awareness programs among college and university students.
Self-Regulation and Shame as Mediators Between Childhood Experiences and Young Adult Health
Authors: Rollins Elizabeth Mathews , Crandall AliceAnn
Published: April 2021

The purpose of this study was to determine whether self-regulation and shame mediated the relationship between adverse and positive childhood experiences (ACEs and PCEs) and young adult health. Data came from the Flourishing Families Project (FFP), a 10-year longitudinal study. Adolescent participants (N = 489; 51% female) completed an annual survey. Data were analyzed using structural equation modeling. Results indicated that PCEs negatively predicted shame and positively predicted self-regulation while ACEs negatively predicted self-regulation. Shame mediated the relationship between PCEs and depression. Self-regulation mediated the relationship between both ACEs and PCEs with anxiety; self-regulation also mediated the relationship between ACEs and substance abuse. Childhood experiences appear to affect the development and maintenance of self-regulation in adolescence. Self-regulation appears to be especially important in protecting against depression, anxiety, and substance abuse in young adulthood.
ICD-11 Personality Disorders: A Psychodynamic Perspective on Personality Functioning
Authors: Blüml Victor , Doering Stephan
Published: April 2021

The new ICD-11 introduces a fully dimensional classification of personality disorders representing a fundamental change in personality disorder diagnosis with major implications for clinical practice and research. The new system centers on the evaluation of the severity of impairment in the areas of self and interpersonal functioning. This focus on personality functioning converges with long-standing psychoanalytic/psychodynamic conceptualizations of personality pathology. In a detailed conceptual analysis and review of existing empirical data, points of convergence and notable differences between major exponents of the psychodynamic tradition—object relations theory as developed by Kernberg et al. and the Operationalized Psychodynamic Diagnosis—and the ICD-11 system are critically discussed. Personality functioning can be considered to be the current “common ground” for the assessment of personality disorders and constitutes a considerable step forward in making personality disorder diagnosis both clinically meaningful and suitable for research purposes.
Understanding the Methodological Issues and Solutions in the Research Design of Stroke Caregiving Technology
Authors: Lobo Elton H. , Frølich Anne , Rasmussen Lene J. , Livingston Patricia M. , Grundy John , Abdelrazek Mohamed , Kensing Finn
Published: April 2021

The rise in the number of cases of stroke has resulted in a significant burden on the healthcare system. As a result, the majority of care for the person living with stroke occurs within the community, resulting in caregivers being a central and challenged agent in care. To better support caregivers during the recovery trajectory poststroke, we investigated the role of health technologies to promote education and offer various kinds of support. However, the introduction of any new technology comes with challenges due to the growing need for more user-centric systems. The integration of user-centric systems in stroke caregiving has the potential to ensure long-term acceptance, success, and engagement with the technology, thereby ensuring better care for the person living with stroke. We first briefly characterize the affordances of available technologies for stroke caregiving. We then discuss key methodological issues related to the acceptance to such technologies. Finally, we suggest user-centered design strategies for mitigating such challenges.
Addressing Fairness, Bias, and Appropriate Use of Artificial Intelligence and Machine Learning in Global Health
Authors: Fletcher Richard Ribón , Nakeshimana Audace , Olubeko Olusubomi
Published: April 2021

In Low- and Middle- Income Countries (LMICs), machine learning (ML) and artificial intelligence (AI) offer attractive solutions to address the shortage of health care resources and improve the capacity of the local health care infrastructure. However, AI and ML should also be used cautiously, due to potential issues of fairness and algorithmic bias that may arise if not applied properly. Furthermore, populations in LMICs can be particularly vulnerable to bias and fairness in AI algorithms, due to a lack of technical capacity, existing social bias against minority groups, and a lack of legal protections. In order to address the need for better guidance within the context of global health, we describe three basic criteria (Appropriateness, Fairness, and Bias) that can be used to help evaluate the use of machine learning and AI systems: 1) APPROPRIATENESS is the process of deciding how the algorithm should be used in the local context, and properly matching the machine learning model to the target population; 2) BIAS is a systematic tendency in a model to favor one demographic group vs another, which can be mitigated but can lead to unfairness; and 3) FAIRNESS involves examining the impact on various demographic groups and choosing one of several mathematical definitions of group fairness that will adequately satisfy the desired set of legal, cultural, and ethical requirements. Finally, we illustrate how these principles can be applied using a case study of machine learning applied to the diagnosis and screening of pulmonary disease in Pune, India. We hope that these methods and principles can help guide researchers and organizations working in global health who are considering the use of machine learning and artificial intelligence.
Periodontal Treatment Protocol for Decompensated Diabetes Patients
Authors: Dallaserra Matías , Morales Alicia , Hussein Nayib , Rivera Marcela , Cavalla Franco , Baeza Mauricio , Strauss Franz J. , Yoma Yazmin , Suazo Claudio , Jara Gisela , Contreras Johanna , Villanueva Julio , Valenzuela-Villarroel Francisca , Gamonal Jorge
Published: April 2021

Background: Decompensated diabetes is associated with a higher prevalence and severity of periodontitis and poorer response to periodontal therapy. It is conceivable that periodontal therapy may cause systemic and local complications in this type of patients. The aim of the present study was to identify and describe the best available evidence for the treatment of periodontitis in decompensated diabetics.

Material and methods: An expert committee including participants from different areas gathered to discuss and develop a treatment guideline under the guidance of the Cochrane Associate Center, Faculty of Dentistry, University of Chile. In total, four research questions were prepared. The questions prepared related to decompensated diabetic patients (glycated hemoglobin >8) were, (1) Does the exposure to periodontal treatment increase the risk of infectious or systemic complications? (2) Does the antibiotic treatment or prophylaxis, compared to not giving it, reduce infectious complications? (3) Does the exposure to periodontal treatment, compared to no treatment, reduce the glycated hemoglobin levels (HbA1c)? Last question was related to diabetic patients, (4) Does the exposure to a higher level of HbA1c, compared to stable levels, increase the risk of infectious complications? Based on these questions, a search strategy was developed using MEDLINE and EPISTEMONIKOS. Only systematic reviews were considered.

Results: For question 1, the search yielded 12 records in EPISTEMONIKOS and 23 in MEDLINE. None of these studies addressed the question. For question 2, the search yielded 58 records in EPISTEMONIKOS and 11 in MEDLINE. None of these studies addressed the question. For question 3, the search yielded 16 records in EPISTEMONIKOS and 11 in MEDLINE. Thirteen addressed the question. For question 4, the search yielded 7 records in EPISTEMONIKOS and 9 in MEDLINE. One addressed the question.

Conclusions: In decompensated diabetic patients, there is lack of scientific information about risk of infectious or systemic complications as a result of periodontal treatment and about the impact of antibiotic treatment or prophylaxis on reduction if infectious complications. A defined HbA1c threshold for dental and periodontal treatment in diabetic patients has yet to be determined. Finally, periodontal treatment does have an impact on HbA1c levels.
UnrealHaptics: Plugins for Advanced VR Interactions in Modern Game Engines
Authors: Rosskamp Janis , Meißenhelter Hermann , Weller Rene , Rüdel Marc O. , Ganser Johannes , Zachmann Gabriel
Published: April 2021

We present UnrealHaptics, a plugin-architecture that enables advanced virtual reality (VR) interactions, such as haptics or grasping in modern game engines. The core is a combination of a state-of-the-art collision detection library with support for very fast and stable force and torque computations and a general device plugin for communication with different input/output hardware devices, such as haptic devices or Cybergloves. Our modular and lightweight architecture makes it easy for other researchers to adapt our plugins to their requirements. We prove the versatility of our plugin architecture by providing two use cases implemented in the Unreal Engine 4 (UE4). In the first use case, we have tested our plugin with a haptic device in different test scenes. For the second use case, we show a virtual hand grasping an object with precise collision detection and handling multiple contacts. We have evaluated the performance in our use cases. The results show that our plugin easily meets the requirements of stable force rendering at 1 kHz for haptic rendering even in highly non-convex scenes, and it can handle the complex contact scenarios of virtual grasping.
Endomyometriosis of the Rectum With Disseminated Peritoneal Leiomyomatosis 8 Years After Laparoscopic Myomectomy: A Case Report
Authors: La Greca Giorgio , Colarossi Cristina , Di Mattia Paolo , Gozzo Cecilia , De Zuanni Marco , Piombino Eliana , Memeo Lorenzo
Published: April 2021

Endomyometriosis is a rare finding and it can be challenging to diagnose and to treat. It can arise in the uterus, in the ovary, in the broad ligament, in the peritoneal surface and in other pelvic structures. Usually patients with endomyometriosis are asymptomatic, but symptoms could occur due to large dimensions or site of the mass. We present a case of a 49-year-old woman with a symptomatic pelvic mass in the rectal wall, with no history of endometriosis, who underwent laparoscopic myomectomy 8 years earlier.
Pig Farmers' Perceptions of Economic Incentives to Control Salmonella Prevalence at Herd Level
Authors: Olsen Jakob Vesterlund , Christensen Tove , Jensen Jørgen Dejgaard
Published: April 2021

This paper investigates how perceived costs and benefits of Salmonella control among Danish pig farmers affect the farmers' choice of action toward reducing the prevalence of Salmonella in their herds. Based on data from an online questionnaire involving 163 Danish pig farmers, we find a considerable uncertainty among pig farmers about the perceived effects of the Salmonella reducing actions. The results indicate large variations in the perceived costs of implementing different types of Salmonella reducing actions (management-, hygiene- and feed-related). For some cases, farmers associate net benefits and positive productivity effects with implementation of the actions while studies by the industry indicate net costs to the farmers. Differences among farmers support the idea of an outcome-based Salmonella penalty scheme but the large uncertainties about costs and effects of actions toward Salmonella control might hamper the effectiveness of such a penalty scheme as a regulatory instrument to affect farmer behavior.
Single Cell Gene Transcriptome Analysis of Ovarian Mature Teratomas
Authors: Shin Sun , Choi Youn Jin , Jung Seung-Hyun , Chung Yeun-Jun , Lee Sug Hyung
Published: April 2021

Teratoma is a type of germ cell tumor that originates from totipotential germ cells that are present in gonads, which can differentiate into any of the cell types found in adult tissues. Ovarian teratomas are usually mature cystic teratomas (OMCTs, also known as dermoid cysts). Chromosome studies in OMCTs show that the chromosomes are uniformly homozygous with karyotype of 46, XX, indicating that they may be parthenogenic tumors that arise from a single ovum after thefirst meiotic division. However, the tissues in OMCTs have been known to be morphologically and immunophenotypically identical to the orthotopic tissues. Currently, expression profiles of tissue components in OMCTs are not known. To identify whether OMCT tissues are expressionally similar to or different from the orthotopic tissues, we adopted single-cell RNA-sequencing (scRNA-seq), and analyzed transcriptomes of individual cells in heterogenous tissues of two OMCTs. We found that transcriptome profiles of the OMCTs at single cell level were not significantly different from those of normal cells in orthotopic locations. The present data suggest that parthenogeneticlly altered OMCTs may not alter expression profiles of inrivirual tissue components in OMCTs.
Integrated Application of K and Zn as an Avenue to Promote Sugar Beet Yield, Industrial Sugar Quality, and K-Use Efficiency in a Salty Semi-Arid Agro-Ecosystem
Authors: Mekdad Ali A. A. , Shaaban Ahmed , Rady Mostafa M. , Ali Esmat F. , Hassan Fahmy A. S.
Published: April 2021

Salinity combined with a deficiency of potassium (K) and zinc (Zn) negatively affect sugar beet yield and quality. A two-year (2017/18–2018/19) field trial was undertaken to investigate the mediating role of soil-applied K [120 (K120) and 180 (K180) kg ha−1] and foliar-applied Zn [0 (Zn0), 150 (Zn150), and 300 (Zn300) ppm] in alleviating salt-stress (8.60 dS m−1) based on sugar beet morpho-physiological responses, sugar yield and quality, and K-use efficiency in the BTS 301 and Kawemira cultivars. Application of K180 × Zn300 was more effective and resulted in 23.39 and 37.78% higher root yield (RY) and pure sugar yield (PSY), respectively, compared to control (K120 × Zn0). It also enhanced sucrose, pure sugar (PS), and purity but decreased impurities (α-amino N, K, and Na), alkalinity index, and sugar loss. However, the K120 × Zn300 recorded higher K-use efficiency. PSY correlated positively (r = 0.776 **, 0.629 **, 0.602 **, 0.549 **, and 0.513 **) with RY, root fresh weight (RFW), top yield, PS, and root diameter, respectively. The stepwise and path-coefficient analysis demonstrated that RY, PS, and RFW were the most influential PSY-affected attributes. Integration of K180 + Zn300 can correct K and Zn deficiencies in the soil and mitigate salt-stress effects via improving sugar beet growth, yield and quality, and K-use efficiency.
Induction of Promoter DNA Methylation Upon High-Pressure Spraying of Double-Stranded RNA in Plants
Authors: Dalakouras Athanasios , Ganopoulos Ioannis
Published: April 2021

Exogenous application of RNA molecules is a potent method to trigger RNA interference (RNAi) in plants in a transgene-free manner. So far, all exogenous RNAi (exo-RNAi) applications have aimed to trigger mRNA degradation of a given target. However, the issue of concomitant epigenetic changes was never addressed. Here, we report for the first time that high-pressure spraying of dsRNAs can trigger de novo methylation of promoter sequences in plants.
Antimicrobial Resistance Patterns of Escherichia coli Isolated from Sheep and Beef Farms in England and Wales: A Comparison of Disk Diffusion Interpretation Methods
Authors: Doidge Charlotte , West Helen , Kaler Jasmeet
Published: April 2021

Little data exist on the levels of antimicrobial resistance from bacteria isolated from British sheep and beef cattle. The aim of this study was to investigate antimicrobial resistance patterns on sheep and beef farms in England and Wales using multiple interpretation methods. Fecal samples (n = 350) from sheep and beef cattle were collected from 35 farms. Disk diffusion antimicrobial susceptibility testing against ten antimicrobials was carried out for 1115 (699 sheep, 416 beef) β-glucuronidase-positive Escherichia coli isolates. Susceptibility was interpreted using clinical breakpoints, which determine clinically resistant bacteria, and epidemiological and livestock-specific cut-off values, which determine microbiological-resistant bacteria (non-wild type). Using livestock-specific cut-off values, a high frequency of wild type for all ten antimicrobials was observed in isolates from sheep (90%) and beef cattle (85%). Cluster analysis was performed to identify patterns in antimicrobial resistance. Interpretation of susceptibility using livestock-specific cut-off values showed a cluster of isolates that were non-wild type to cefotaxime and amoxicillin/clavulanic acid, whereas clinical breakpoints did not. A multilevel logistic regression model determined that tetracycline use on the farm and soil copper concentration were significantly associated with tetracycline non-wild type isolates. The results suggest that using human clinical breakpoints could lead to both the under-reporting and over-reporting of antimicrobial resistance in sheep and beef cattle.
Amino Acid Signature of Oxidative Stress in Patients with Type 2 Diabetes: Targeted Exploratory Metabolomic Research
Authors: Bala Cornelia G. , Rusu Adriana , Ciobanu Dana , Bucsa Camelia , Roman Gabriela
Published: April 2021

Oxidative stress plays a key role in the development of chronic diabetes-related complications. Previous metabolomic studies showed a positive association of diabetes and insulin resistance with branched-chain amino acids (AAs) and aromatic AAs. The purpose of this research is to identify distinct metabolic changes associated with increased oxidative stress, as assessed by nitrotyrosine levels, in type 2 diabetes (T2DM). Serum samples of 80 patients with insulin-treated T2DM are analyzed by AA-targeted metabolomics using ultrahigh-performance liquid chromatography/mass spectrometry. Patients are divided into two groups based on their nitrotyrosine levels: the highest level of oxidative stress (Q4 nitrotyrosine) and lower levels (Q1–Q3 nitrotyrosine). The identification of biomarkers is performed in MetaboAnalyst version 5.0 using a t-test corrected for false discovery rate, unsupervised principal component analysis and supervised partial least-squares discriminant analysis (PLS-DA). Four AAs have significantly different levels between the groups for highest and lower oxidative stress. Cysteine, phenylalanine and tyrosine are substantially increased while citrulline is decreased (p-value <0.05 and variable importance in the projection [VIP] >1). Corresponding pathways that might be disrupted in patients with high oxidative stress are phenylalanine, tyrosine and tryptophan biosynthesis, arginine biosynthesis, phenylalanine metabolism, cysteine and methionine metabolism and tyrosine metabolism.
Risk Index Method—A Tool for Building Fire Safety Assessments
Authors: Brzezińska Dorota , Bryant Paul
Published: April 2021

The use of fire safety engineering and performance-based techniques continues to grow in prominence as building design becomes more ambitious, increasing complexity. National fire safety enforcement agencies are tasked with evaluating and approving the resulting fire strategies, which have similarly continued to become more advanced and specialist. To assist with the evaluation of fire strategies, this paper introduces a methodology dedicated to sustainable building fire safety level simulations. The methodology derives from ideas originally introduced in British Standard Specification PAS 911 in 2007 and combines a visual representation of fire strategies with a semi-quantitative approach to allow for their evaluation. The concept can be applied to a range of industrial fire safety assessments and can be modified for specific needs relative to different industries.
Strength Development and Microstructural Behavior of Soils Stabilized with Palm Oil Fuel Ash (POFA)-Based Geopolymer
Authors: Khasib Isam Adnan , Daud Nik Norsyahariati Nik , Nasir Noor Azline Mohd
Published: April 2021

Using geopolymer in soil stabilization has gained much attention recently due to its efficiency in improving soil properties and being environmentally friendly at the same time. This research aims to investigate the effect of palm oil fuel ash (POFA)-based geopolymer on soft soil stabilization. The mechanical and microstructural performance of two types of clay soil treated with geopolymer produce from POFA material was the focus of this study. In this respect, a series of unconfined compression and direct shear tests were conducted to investigate the mechanical properties of soils treated with POFA-based geopolymer. Furthermore, the microstructural changes in the treated samples were analyzed using field emission electron microscopy (FESEM) and energy dispersive X-ray (EDX). In accordance with the results, it was indicated that the shear strength of both soils soared by increasing the dosage of POFA-based geopolymer. Geopolymer with 40% POFA of the dry weight of soils yielded the highest UCS value at both curing periods, 7 and 28 days. Furthermore, the microstructural analysis revealed material modifications (N-A-S-H gel formation) related to strength enhancement. These results suggest the potentiality of using a POFA-based geopolymer binder to stabilize soft soil.
Statistical Characterization of Supraharmonics in Low-Voltage Distribution Networks
Authors: De Falco Pasquale , Varilone Pietro
Published: April 2021

Modern power systems are subject to waveform distortions that include spectral components (supraharmonics) in the range of 2–150 kHz. Due to the lack of regulation in this range and since supraharmonics may follow time-varying patterns, the operators can take advantage of the statistical characterization of supraharmonics, e.g., for determining convenient power quality limits or to analyze the residual capacity of networks toward further installations of power electronic converters. This paper studies the statistical characterization of supraharmonics in low-voltage distribution networks, considering both the overall supraharmonic distortion (through the characterization of the total supraharmonic distortion index) and individual supraharmonic components. Several probability distributions are proposed and compared, also considering multimodal distributions that can fit more general scenarios in which the supraharmonic emissions follow regime patterns. The outcome of numerical experiments based on publicly available data collected at actual low-voltage distribution networks suggests that multimodal distributions are useful in characterizing supraharmonics in most cases, with acceptable goodness of fitting even in the presence of stair-shaped empirical distributions. This paper can serve as a starting point for the development of probabilistic power system analysis tools accounting for supraharmonic emissions and for the convergence toward standardization in the 2–150 kHz range.
Nitrogen Removal Using a Membrane Bioreactor with Rubber Particles as the Fouling Reducer
Authors: Choi Moon-Su , Hwang Yuhoon , Lee Tae-Jin
Published: April 2021

The use of granule activated carbon (GAC) and rubber particles as the bio-fouling reducer in a membrane bioreactor (MBR) was evaluated in this study. The addition of GAC tends to temporarily reduce Transmembrane Pressure (TMP). Then, after the initial reduction, TMP gradually increased back up to 0.7 bar, indicating significant fouling on the membrane. Low TMP values were observed after adding 0.5% (V/V) rubber particles to the same MBR. The organic compound and nitrogen removal efficiencies of the MBR under intermittent aeration were over 94% and 93.3%, respectively. The results showed that Dysgonomonas, Acidobacteria, and Pantoea sp. contributed to the nitrification process while Lactobacillus, Erythrobacter, Phytobacter, and Mycobacterium contributed to the denitrification process.
Increasing Wind Turbine Drivetrain Bearing Vibration Monitoring Detectability Using an Artificial Neural Network Implementation
Authors: Strömbergsson Daniel , Marklund Pär , Berglund Kim
Published: April 2021

The highest costs due to premature failures in wind turbine drivetrains are related to defects in the gearbox, with bearing failures being overrepresented. Vibration monitoring has been identified as the primary tool to detect and diagnose these types of failures. However, late or no signs of the failures are still being reported. Artificial neural networks (ANNs) has been shown to favourably be used as a classifier of bearing failures to increase the detection and diagnosis performance, which requires labelled data when training for all types of considered failures. However, less work has been done with an ANN used to create descriptive functions of the vibration and turbine operation data relationship and thereby negating inherent variance in the vibration data and increasing the detectability when a defect appears. Therefore, this study utilizes the relationship between the rotational speed recorded during a vibration measurement and the calculated condition indicator values of specific bearing failures in three wind turbine gearbox failures. An ANN establishes a function between the rotational speed and condition indicator values with healthy training data collected before the failure occurred. Thereafter, whole datasets leading up to the changing of the gearboxes is used to predict the condition indicator values without the failure influence. The difference between the predicted and true values show an increased sensitivity of the detection in two cases of gearbox output shaft bearing failures as well as indicating a planet bearing failure which with the previous data had gone undetected.
A Simple Device for the On-Site Photodegradation of Pesticide Mixes Remnants to Avoid Environmental Point Pollution
Authors: Esposito Biagio , Riminucci Francesco , Di Marco Stefano , Metruccio Elisa Giorgia , Osti Fabio , Sangiorgi Stefano , Ferri Elida Nora
Published: April 2021

The worldwide increase in the number and use of agrochemicals impacts nearby soil and freshwater ecosystems. Beyond the excess in applications and dosages, the inadequate management of remnants and the rinsing water of containers and application equipment worsen this problem, creating point sources of pollution. Advanced oxidation processes (AOPs) such as photocatalytic and photo-oxidation processes have been successfully applied in degrading organic pollutants. We developed a simple prototype to be used at farms for quickly degrading pesticides in water solutions by exploiting a UV–H2O2-mediated AOP. As representative compounds, we selected the insecticide imidacloprid, the herbicide terbuthylazine, and the fungicide azoxystrobin, all in their commercial formulation. The device efficiency was investigated through the disappearance of the parent molecule and the degree of mineralization. The toxicity of the pesticide solutions, before and during the treatment, was assessed by Vibrio fischeri and Pseudokirchneriella subcapitata inhibition assays. The results obtained have demonstrated a cost-effective, viable alternative for detoxifying the pesticide solutions before their disposal into the environment, even though the compounds, or their photoproducts, showed different sensitivities to physicochemical degradation. The bioassays revealed changes in the inhibitory effects on the organisms in agreement with the analytical data.
End-of-Life Tyres: Comparative Life Cycle Assessment of Treatment Scenarios
Authors: Bianco Isabella , Panepinto Deborah , Zanetti Mariachiara
Published: April 2021

Waste tyres and their accumulation is a global environmental concern; they are not biodegradable, and, globally, an estimated 1.5 billion are generated annually. Every year around 350,000 tons of end-of-life tyres (ELT) are managed in Italy, collected from cars, two-wheeled vehicles, trucks, up to large quarry vehicles and agricultural vehicles. ELTs are collected and sent for material or energy recovery, in line with the circular economy principles. This paper investigates the environmental impacts of two common scenarios of ELT treatments. Specifically, it is analysed the recycling of crumb rubber (CR, deriving from the tyre shredding) for the composition of bituminous mixtures for the wearing course of roads. This scenario is compared with the energy recovery route in a dedicated incinerator. To this aim the standardised methodology of Life Cycle Assessment (ISO 14040-44) is employed. Results shows that for most part of the impact categories analysed, the material recovery presents higher environmental benefits if compared with energy recovery.
Wideband-Narrowband Switchable Tapered Slot Antenna for Breast Cancer Diagnosis and Treatment
Authors: Lim Seonho , Yoon Young Joong
Published: April 2021

In this paper, a wideband-narrowband switchable tapered slot antenna (TSA) with a compact meander line resonator for an integrated microwave imaging and hyperthermia system was proposed. A compact meander line resonator, which exhibited band-pass characteristics and provided narrowband characteristics by using one PIN diode, was fabricated beneath the tapered slot of the wideband TSA to minimize the degradation of the wideband characteristics. Moreover, the electromagnetic energy was transferred to the meander line resonator with a coupling effect to ensure effective frequency switching. By adapting a PIN diode on the meander line resonator, frequency switching could be achieved. In this way, the proposed antenna could operate in a real-time frequency switching mode between the ultra-wideband (UWB; 3.1~10 GHz), which is used for microwave imaging, and the 2.45 GHz band (industrial, scientific, and medical, ISM band), which is used for microwave hyperthermia. Frequency and time-domain results proved the applicability of the proposed antenna to an integrated breast cancer detection and treatment system.
The PCL Envelope Lack Sign (PELS) Is a Direct Arthroscopic Sign of Chronic Posterior Cruciate Ligament Insufficiency
Authors: Góralczyk Adrian , Mostowy Marcin , Ebisz Michał , LaPrade Robert F. , Sibilska Aleksandra , Hermanowicz Krzysztof , Domżalski Marcin E. , Malinowski Konrad
Published: April 2021

Purpose: To present the arthroscopic “PCL envelope lack sign” (PELS) and to calculate its diagnostic characteristics in chronic PCL insufficiency. Methods: Recordings of knee arthroscopies performed in a single clinic between April 2015 to March 2020 were retrospectively evaluated, searching for the “PCL envelope”. It was defined as a “soft tissue cuff coursing around the PCL tibial attachment, visible with the arthroscope positioned between the PCL, medial femoral condyle and posterior horn of the medial meniscus at the level of its shiny white fibers”. PELS was defined as “the PCL adhering to the proximal tibia adjacent to the medial meniscal posterior root attachment, inability to observe the normal space between the PCL and posterior tibia and no soft tissue cuff around the PCL tibial attachment”. Inclusion criteria were possibility to evaluate the PELS presence on recordings. Patients who underwent PCL reconstruction were assigned to the study group. The rest of the patients were controls. Criteria to operate on symptomatic PCL patients were at least 5 mm of posterior instability in physical examination and at least 6 months post-injury. Results: Out of 614 available recordings, 592 patients (205 females, 387 males; mean age 45.2 years, SD = 14.36, range 14–81) were included: 38 in the study group and 554 in the control group. In the study group, PELS was positive in 36 of 38 cases (94.7%). In the control group, PELS was negative in 554 PCL-efficient patients (100%). Calculated PELS sensitivity was 94.7%, specificity 100%, positive predictive value 100%, negative predictive value 99.6%. The PELS was present significantly more often in PCL-insufficient patients, p < 0.001. Conclusions: The PCL envelope lack sign was found to be a highly effective tool to arthroscopically confirm chronic PCL insufficiency, and should be considered a direct sign of chronic posterior knee instability.
Particle Size Analysis of African Dust Haze over the Last 20 Years: A Focus on the Extreme Event of June 2020
Authors: Euphrasie-Clotilde Lovely , Plocoste Thomas , Brute France-Nor
Published: April 2021

Over the last decades, the impact of mineral dust from African deserts on human health and climate has been of great interest to the scientific community. In this paper, the climatological analysis of dusty events of the past 20 years in the Caribbean area has been performed using a particulate approach. The focus is made on June 2020 extreme event dubbed “Godzilla”. To carry out this study, different types of data were used (ground-based, satellites, model, and soundings) on several sites in the Caribbean islands. First, the magnitude of June 2020 event was clearly highlighted using satellite imagery. During the peak of this event, the value of particulate matter with an aerodynamic diameter of less than 10 μμm (PM10) reached a value 9 times greater than the threshold recommended by the World Health Organization in one day. Thereafter, the PM10, the aerosol optical depth, and the volume particle size distribution analyses exhibited their maximum values for June 2020. We also highlighted the exceptional characteristics of the Saharan air layer in terms of thickness and wind speed for this period. Finally, our results showed that the more the proportion of particulate matter with an aerodynamic diameter of less than 2.5 μμm (PM2.5) in PM10 increases, the more the influence of sea salt aerosols is significant.