bluuebunny/crossref_metadata_2025 huggingface dataset:
Hiv-Related Progressive Multifocal Leukoencephalopathy: A Case Report
Authors: Brrang Rajni Kaur , Basmaci Ilayda , Fakidi Zinovia , Istrate Raluca Ileana , Hangan Aurelia
Published: December 2024

The JC virus is widespread within individuals across the globe. It is usually in a latent form, but if immunity is decreased in a person this virus is reactivated leading to progressive multifocal leukoencephalopathy (PML). This is a rare neurological disease that can occur in cases of uncontrolled HIV/ AIDS. This report aims to highlight the importance of patients with HIV following a strict treatment regime and ensuring that this message is expressed to them by physicians in practice. We specifically report a patient case study in which our patient was non-compliant with his HIV medication, leading to neurological deficits. On admission, our patient presented with left limb paraesthesia, walking difficulties, and temporospatial disorientation. Many investigations and bedside tests were carried out before an MRI confirmed the presence of demyelinating gliotic lesions in the brain, leading to the diagnosis of PML. Due to the nature of PML, despite antiviral treatment, his condition progressively worsened. He presented two months later with further neurological pathologies, specifically a visual field disorder. Despite this disease being rare, the aim of this paper is to place emphasis on the lethality of the condition, therefore shifting a focus on preventing the disease in the first place via patient compliance with HIV medication.
Vacation Planning Application using API
Authors: Paula-Florina Gulean
Published: December 2024

Choosing and booking a vacation can be difficult when the application where these things are done is not user-friendly. Therefore, the application that I have created will have to make the user experience much more pleasant. The purpose of the application is to be able to choose a holiday according to the desired filters, with the option to search for a flight in the same period. After booking it, the user who created an account will have stored in his account all the reservations made. Using the logic behind this application, any travel agency can create a new interface that they can customize according to their wishes, but the functionalities remain the same. They can also change what data they want to receive from the API, what data they want to store in their database and in addition modify the offers according to their wishes.
Electronic voting system using Blockchain technology
Authors: Nicolae-Marian Buliga
Published: December 2024

This paper presents an application for a voting system that uses blockchain technology. As is known, blockchain technology has a wide range of applications. What makes it suitable for a voting system is that it can prevent fraud. Another advantage of using blockchain technology for a voting system is that it offers unlimited system availability: the system’s operation is not affected by certain factors, such as power outages, updates or network connection.
Explore the intersection of Self-Determination Theory and cybersecurity education - A literature review
Authors: Feraru Iulia , Bacali Laura
Published: December 2024

This paper explores how organizations can create a sustainable, security-first culture in an increasingly complex environment where organizational and national cultures are strong influencing factors in human behaviour. In cybersecurity education, as in any effort of education, there must be a principled commitment to long-term behaviour modification through intrinsic motivation, foundational to employees acting consistently in secure ways. The review of the literature falls squarely within Self-Determination Theory, underlining the pertinence of autonomy, competence, and relatedness as distinctive factors in cybersecurity education, highlighting that these constructs are necessary at all levels for perpetual security and compliance.

The results indicated that an effective security-first culture could only emerge when cybersecurity formed part of the core values and practices within organizations. It also explained that leadership styles, such as transformational and servant leadership, play an important role in the development of intrinsic motivation by fostering trust, empowerment, and a sense of shared responsibility. It also highlights how national cultural dimensions, such as individualism and power distance, may change how differently oriented employees respond to cybersecurity policies and practices. Approaches to cybersecurity education should be tailored to both organizational and national cultural factors to develop cybersecurity education strategies that could go beyond mere compliance and build a proactive security mindset. This is important because it underlines how the SDT acts as a framework for understanding how companies could help foster a security-first culture that, at the same time, will create sustainable, resilient, and intrinsically driven cybersecurity behaviours among employees.
A robotic arm for playing chess
Authors: Paţanghel Cristian Florian , Breazu Macarie
Published: December 2024

The main goal of this research was to design and implement a robotic arm for playing chess on three standard real boards handling real regular pieces. Research, design and redesign were done on all aspects of the development: mechanical, hardware and software. A lot of problems emerged, but were overcome, and the robotic arm met its goal: to reliably moves chess pieces on the boards with millimetric positioning precision.

Interfacing the PC to 3 DGT autosensory boards and interfacing the PC with a classic software chess engine should be further considered.
The Emerging Technologies: The Drivers for Digital Transformation in Business and Education
Authors: Florea Adrian
Published: December 2024

Emerging technologies, including Blockchain, Quantum Computing, Artificial Intelligence (AI), and Internet of Things (IoT), whether utilized individually or in combinations such as AIoT and IIoT, possess a disruptive nature that is poised to fundamentally reshape the functioning of specific industries, education, and society at large. These technologies act as catalysts for digital transformation, fostering the emergence of novel business models and opportunities for development. Launched as an initiative of the Cluj IT cluster and supported by the Hasso Plattner Institute in Potsdam, Germany, Sibiu Innovation Days (SID) represented a necessity for Sibiu, for the university, for companies in the area, in the idea of bringing together of all decision makers that acts around the concepts of digitalization, innovation and knowledge transfer to a smarter society and a better life for its members. Emerging technologies can exploit Romania’s connectivity and broadband capabilities, where Romania is above the European average, bringing it into line with and keeping pace with developed countries in terms of the digitalization of industry, agriculture and society as a whole. In this regard, we believe that no effort is useless to increase Romania’s innovation performance, and through the activities carried out at Sibiu Innovation Days 2024, solutions to some of these challenges were addressed and proposed.
“I Will Stitch it Back and Pass it Down”: A Bai Elder Makes and Teaches Buzha
Authors: Kay Jon
Published: December 2024

This essay explores how traditional arts impact the lives of older adults, especially those recognized as inheritors of an Intangible Cultural Heritage (ICH). Through the work of elder Bai artist Mrs Zhao Huaizhu, I consider how traditional hand-icrafts and cultural knowledge enhance elder wellbeing and foster intergenerational connections. Mrs Zhao is a master of buzha, a traditional Bai art form where embroidered silk items are filled with wormwood and other aromatic herbs. Recognized as an ICH inheritor, Mrs Zhao invests her silk creations with Bai folklore, local history, and personal narratives. She uses her creations to convey cultural values and impart her individual identity. Engaging in this expressive practice not only gives Mrs Zhao’s life purpose and meaning, but also allows her to contribute to the economic and cultural vitality of her Bai community. This case study underscores the reciprocal relationship between ICH practices and the elders who practice them. Blending folklore methods with gerontological perspectives, the essay makes clear that traditional arts and cultural performances can work to support the quality of life of older adults. While elder artisans may be vital for sustaining traditional knowledge and practices, active participation in these cultural productions also enhance their emotional, psychological, physical, and social wellbeing, which is seldom a consideration in scholarly and governmental conversations about the value of ‘heritage’ conservation efforts.
The Role of Cultural Values in Business and Society
Authors: Corlăteanu Aniela Ioana
Published: December 2024

For managers or business people visiting a foreign country, understanding national values through surveys like Hofstede’s (1980) can be extremely beneficial. These surveys identify the acceptable values, ideas, and behaviors in a country, which helps avoid offending locals. Hofstede identifies four value dimensions, while the GLOBE survey (House, 2004) identifies nine. Additionally, a country’s cultural values can be inferred from people’s statements about their culture and what is rewarded or punished in various institutions. Values are embedded from the culture in the process of socialization and, once learned, tend to be resistant to change. A society’s institutions carry the culture’s values in their ideologies. Value differences between members of different cultures can lead to misunderstandings and conflict.
Abuse Through Power and Control in Human Societies – Essence, Characteristics and Effects
Authors: Petrova Elitsa
Published: December 2024

The object of the present scientific theoretical study is the abuse of power and control as a socially undesirable phenomenon in human behaviour and in human communities. The article examines the topics of power abuse and violence in a social structure, regardless of whether it is the workplace or another human community, the phenomena of harassment, mobbing, bossing and aggression as are considered as counterproductive social human behaviours. The scientific methodology used is a combination of an etymological review of the considered phenomena of violence, harassment, mobbing, bossing and aggression, content analysis of the concepts of the considered phenomena, combined with a critical scientific review. In conclusion, the idea of psychological safety is presented, which refers to the belief that being oneself, expressing oneself and one’s positions is not only useful for a human group, organization, community but must be safe for the individual, emphasizing the creation of a safe surrounding environment.
Analysis on the Employees’ Perception of Leadership, in a Company With a Production Profile in Romania
Authors: Todăriță Elida-Tomița , Miricescu Dan
Published: December 2024

The success of an organization consists of a multitude of factors and elements, which combined perfectly lead to the achievement of the best performing standards. The frequently asked question is not whether an organization can be successful, but what exactly makes an organization successful. Therefore, we can say that both managers (leaders) and employees have important roles, starting with the objectives and strategies established at the level of the organization and up to their implementation and the relationship between them and providing permanent and reciprocal feedback. In a previous study we analyzed the relationship between leaders and employees within organizations with a production profile in Romania, so we considered it necessary to analyze the opinion of employees towards leaders. Thus, the 31 respondents occupy different executive positions within a production company. A questionnaire based on a quantitative analysis was used as a working tool. It consisted of 18 questions (17 closed-ended questions and one open-ended question). The questionnaire was distributed directly (online) using the Google Forms platform. In conclusion, we can say that the employee-leader relationship must also be analyzed from the perspective of the behavior that both have within the organization. Following the study, we can say that leaders are largely satisfied with the behavior and attitude that leaders show towards them in different situations.
Internal Control and Administrative Management: an Empirical Study Applied to SMEs in the Canton of Manta-Ecuador
Authors: Alcívar María Iliana Loor , Franco Silvana Mariela Párraga , Zamora Juan Carlos Sornoza , Hoppe Juan Carlos Cevallos , Chicaiza Julio Cesar Mina
Published: December 2024

Objective: The objective of this research is to analyze the possible relationship between the components of internal control and the administrative management of SMEs located in the canton of Manta in the period 2019-2020.
 
Theoretical Framework: This section presents the main concepts and theories that support the research. [List relevant theories, models, or frameworks] stand out, providing a solid foundation for understanding the context of the research.
 
Methodology: A common framework emerges: the Committee of Sponsoring Organizations of the Treadway Commission (COSO) model as a strategy for organizational operations, aimed at achieving business goals. A sample of 213 individuals working in these organizations was used. One of the most important aspects in any company, regardless of its size or its obligation to keep accounting records, is internal control.
 
Results and Discussion: Multiple linear regression analysis was performed, whose main findings allowed us to determine that there is a positive and statistically significant correlation between the components of these constructs.
 
Implications of the Research: The implications of this research contribute to the design of methodologies and the establishment of strategic internal control tools, allowing managers and employees of SMEs to establish and comply with policies, processes, and undertake improvement actions necessary to improve the competitiveness of these types of companies in the short, medium, and long term.
 
Originality/Value: Through this study, it was possible to determine that one of the fundamental aspects for the proper application of internal control is the level of education of the administrators of these institutions, who in some cases were unaware of internal control, but who applied certain control guidelines verbally and without written procedures, focusing more on the empirical.
Bicycle Tourism as a Sustainable Tourism Alternative in Two Rural Areas of Santo Domingo in Ecuador
Authors: Patricio Galarza Pucha Jairo , Yoarnelys Vasallo-Villalonga
Published: December 2024

Objective: This study aims to identify the profile of cycle tourists visiting the rural areas of San Gabriel de Baba and Julio Moreno, located in Santo Domingo de los Tsáchilas, Ecuador.
 
Theoretical Framework: Sustainable tourism is defined as an activity that considers economic, social, and environmental factors to ensure the satisfaction of both users and host communities.
 
Method: A descriptive method was employed, applying surveys to four study groups with differentiated questionnaires, revealing heterogeneous variability in the responses.
 
Results and Discussion: The results show that these rural areas significantly contribute to sustainable tourism through bicycle usage. However, respondents highlighted the need to improve road signage and safety for cyclists. This aligns with previous studies in Latin America that emphasize the lack of resources in rural areas for infrastructure and the promotion of sustainable tourism.
 
Research Implications: A lack of precise information is observed, which hinders the development of effective marketing strategies for cycle tourism ventures in these areas. The research is considered preliminary due to the limited information available on tourism in the areas studied and the absence of prior analyses characterizing cycle tourists.
 
Originality/Value: In this regard, the descriptive approach adopted allows for the proposal of tools to promote cycle tourism and improve conditions for local communities, thus enhancing the development of economically viable and environmentally responsible tourism.
Adoption of Circular Economy in Sustainable Agriculture Practices in Magelang District: Influence on Productivity and Farmer Welfare
Authors: Prasetyo Andreas Yogi , Yudhanto Wildan , Nurlina Nila , Rosyidah Hani , Indrayati Lyna Lestari
Published: December 2024

Objective: The objective of this study is to investigate the adoption of circular economy principles in sustainable agriculture practices in Magelang district, focusing on their impact on agricultural productivity and farmer welfare, with the aim of assessing how circular economy practices contribute to sustainable agriculture by improving resource efficiency, enhancing productivity, and promoting farmer welfare in Magelang district.
 
Theoretical Framework: The theoretical framework of this study is grounded in the priciples of the circular economy, which emphasize maximizing resource efficiency, minimizing waste, and fostering environmental regeneration. In agriculture, these principles align with sustainable practices by promoting the reuse of organic materials, efficient resource management, and the reduction of chemical inputs to maintain soil fertility and ecosystem balance. By integrating circular economy principles with sustainable agricultural practices, this framework aims to enhance productivity, reduce costs, and improve farmers’ welfare while ensuring long-term environmental resilience.
 
Method: Using a quantitative approach that includes surveys of 100 farmers and in-depth interviews, this research evaluates the implementation of CE principles, such as composting organic waste, rainwater harvesting, and crop rotation.
 
Results and Discussion: The findings indicate that approximately 60% of farmers have adopted at least one CE practice, leading to a productivity increase of up to 25% compared to conventional methods. Additionally, CE adoption has proven to improve income stability and farmer welfare. However, barriers such as limited access to technology and funding reduce broader adoption of sustainable practices.
 
Research Implications: This study recommends government and institutional support through training, technology access, and financial incentives to accelerate CE adoption. It provides actionable reccomendations for policymakers and stakeholders to support the broader adoption of circular economy practices in agriculture.
 
Originality/Value: The originality of this research lies in its focus on the adoption of circular economy principles within the specific context of sustainable agriculture in Magelang District, an area with unique agricultural challenges and potential. This research combines empirical data on productivity and welfare impacts with qualitative insights into local adoption barriers and drivers. By integrating these aspects, the study provides a novel perspective on implementing sustainable agricultural practices tailored to the region’s socioeconomic and environmental conditions.
Estrategia metodológica para la sostenibilidad de servicios ecosistémicos. Caso de aplicación: Tocotá, Valle del Cauca
Authors: Corrales Marín Silvia Milena , Restrepo Tarquino Inés , Corrales Marín Diego Fernando
Published: December 2024

Los servicios ecosistémicos (SE) han sido concebidos como medio de generación de comodidad, felicidad y satisfacción de necesidades de las personas (Gómez, 2020; IPBES, 2017, 2019), lo que implica que son vistos como fuente de recursos para las actividades antrópicas, pero eso ha hecho que su disfrute esté generando efectos negativos en la biodiversidad que los provee (Kulczyk et al., 2017).

Para intentar mitigar dichos impactos, en el marco de la estancia postdoctoral “Estrategia de sostenibilidad socioeconómica de los servicios ecosistémicos de la cuenca alta del río Dagua: Caso de estudio vereda Tocotá, Valle del Cauca” y con el apoyo del proyecto “Implementación de estrategias para la recuperación y manejo integrado del recurso hídrico en cuencas del Valle del Cauca”, se construyó un modelo que se constituye en una estrategia metodológica que permite valorar la sostenibilidad de los servicios ecosistémicos y sugiere acciones para la recuperación o conservación de los ecosistemas que los proveen. El modelo consta de cinco pasos que permiten identificar los servicios ecosistémicos, calificarlos, evaluarlos y generar acciones a seguir para su recuperación y conservación. Para facilitar su aplicación se acompaña de un archivo Excel.

La presente edición incluye un marco conceptual de los servicios ecosistémicos, la estrategia metodológica construida para la valoración de los SE y los resultados de su aplicación en Tocotá, un sitio que se ha convertido en destino turístico de los caleños, gracias a lo llamativo de sus características ambientales.
ANALISIS ORIENTASI PASIEN RAWAT JALAN MELALUI PENDEKATAN WAYFINDING DI RUMAH SAKIT DENGAN MENGGUNAKAN METODE SPACE SYNTAX
Authors: Nadim Arsalan  , Andriyanto Wibisono
Published: December 2024

Analysis of Outpatient Orientation Through Wayfinding Approaches in Hospital Using the Space Syntax Method. The use of wayfinding in hospitals play a crucial role in guiding outpatient orientation. This study aims to assess and evaluate outpatient orientation through the wayfinding approach. It employs a descriptive quantitative method, collecting data through observation and questionnaires filled out by 102 respondents. The data are analyzed using SPSS software to measure patients understanding of orientation in the outpatient area. Additionally, the space syntax method is utilized to analyze two issue regarding spatial legibility in the outpatient area. First orientation and second, the use of wayfinding to enhance effectiveness. Space syntax analysis, conducted using the depthmapX software, aims to identify area causing orientation problems and area with wayfinding issue. The research finding indicate that orientation outpatient capability in the hospital installation exhibits a good level of familiarity, thereby facilitating patient orientation and navigation. However the space syantax results contrasting findings, indicating area that are diffuclt to perceive both visually and in term of distance to rooms, as well as area that serve as activity magnets for patient in the outpatient. Despite patients relatively high understanding of orientation, there are still deficiencies in the use of directional cues. This study provides an evaluation and recommendations to enchance the effectiveness of wayfinding in hospital.
PENERAPAN FENG SHUI BA ZHAI PADA TATA RUANG WARISAN ARSITEKTUR TIONGHOA RUMAH TJONG A FIE
Authors: Makmur Iknu Wijaya  , Sangayu Ketut Laksemi Nilotama
Published: December 2024

The Industrial Revolution not only facilitated extensive natural resource exploitation but also introduced concepts like “harmonization of nature,” ethnic development, and global migration. Among the groups affected was the Tionghoa ethnic community, which migrated from Asia to the West, including Indonesia (Nusantara), while carrying their cultural heritage. The Tjong A Fie Mansion in Medan, Indonesia, serves as a significant architectural artifact, reflecting the principles of Traditional Chinese Architecture Philosophy. This study explores how the mansion embodies these principles, conveying messages and meanings within its architectural patterns. Employing an interdisciplinary approach rooted in cultural studies, this research incorporates the Feng Shui Ba Zhai framework. The methodology includes: 1) collection and classification of data related to the mansion’s cultural and architectural context; 2) analysis and interpretation of its structural elements; and 3) conclusions regarding the messages and meanings conveyed by the architecture. The findings reveal that the Tjong A Fie Mansion utilizes key elements—such as dividing walls, jian (rooms), axis alignment, space orientation, and courtyards—aligned with Feng Shui Ba Zhai principles. Ultimately, this study highlights how cultural messages are preserved through architecture, emphasizing the mansion’s significance as a historical and cultural legacy.
AS ATITUDES DAS PESSOAS QUE VIVEM COM DIABETES MELLITUS TIPO 2 EM RELAÇÃO À DOENÇA SEGUNDO O INSTRUMENTO ATT-19
Authors: Brito Irisdalva França Soares , Silva Ricardo Rogério Santos da , Gomes Andréia Pereira dos Santos , Pereira Fernanda Maria Melo , Gomes Cristiane Oliveira , Moura Maria Edileuza Soares
Published: December 2024

O diabetes mellitus é uma condição crônica que impõe ao indivíduo que vive com esse agravo e familiares mudanças no estilo de vida, buscando mitigar expressivos impactos na sua saúde, além dos gastos elevados para si e para a saúde pública. O objetivo do estudo foi conhecer as atitudes das pessoas que vivem com diabetes mellitus tipo 2 em relação à doença segundo o instrumento ATT-19. Trata-se de um estudo transversal, com abordagem quantitativa, realizado com 62 indivíduos diagnosticados com diabetes mellitus tipo 2, residentes na comunidade Itapecuruzinho zona urbana de Caxias, Maranhão, no período de abril a novembro de 2023. Foram investigados os dados sociodemográficos e clínicos dos participantes do estudo, também aplicado o Diabetes Attitude Questionnarie (ATT-19). Nos resultados, houve predominância do sexo feminino (62,9%), faixa etária de 50 a 69 anos (64,6%), média de idade de 62 anos, autodeclarados pardos (66,1%), casados/ união estável (67,7%), com ensino fundamental (54,8%), aposentados (59,7%), com renda mensal de 1 salário-mínimo (75,8%). Em relação ao arranjo familiar, os usuários coabitavam em sua maioria com pelo menos um membro da família, entre eles cônjuge, filho(a), neto (a), sobrinho (a), genro e/ou nora. Na análise das características clínicas, prevaleceu o tempo de diagnóstico de 2 a 5 anos (41,9%). Quanto à presença de complicações, afirmaram não possuir nenhuma complicação (69,4%) e demonstraram atitude negativa frente ao diabetes (64,6%). O gerenciamento dos casos de pacientes com diabetes na comunidade deve considerar os aspectos biopsicossociais, essa visão é essencial para compreender o processo saúde-doença e promover o bem-estar do indivíduo.
MEMAKNAI KEKHILAFAN HAKIM DALAM PUTUSAN NOMOR 308 K/Pdt.Sus-PHI/2018
Authors: Mustika Prabaningrum Kusumawati
Published: December 2024

These days, the industrialization era is rapidly developing and has impacted industrial relations disputes that are becoming increasingly complex and unavoidable. In the case of industrial relations disputes, difference in the decision between the first instance and the cassation level (there is no appeal for industrial relations disputes) occurs frequently. As such is the case between Siti Harini and PT Batik Danar Hadi, in which the verdicts of the first instance and cassation (Case Number: 37/Pdt.Sus-PHI/2017/PN.Smg and Case Number: 308 K/Pdt.Sus-PHI/2018) and the results of the previous first instance decisions (Case Number: 19/Pdt.Sus-PHI/2017/PN.Smg) differed from one another. In Case Number: 37/Pdt.Sus-PHI/2017/PN.Smg, Siti Harini's lawsuit was granted; in Case Number: 308K/Pdt.Sus-PHI/PN.Smg, PT Batik Danar Hadi's cassation application was granted; howeverin Case Number: 19/Pdt.Sus-PHI/2017/PN.Smg, Siti Harini's lawsuit was dismissed. If the lawsuit is filed while the case at hand is still in the middle of examination at the cassation level, it can be said that the suit is too early (premature) and consequently should be declared inadmissible (Niet Ontvankelijke Verklaard), but in fact it was granted instead. Hence, it can be concluded that there is an error in the judgment making. Conclusively, it can be stated that the implication of an error in the judgment in the first instance creates legal uncertainty and injustice in the decision.
PROSPEK PENGATURAN KOMISI KHUSUS PENYUSUN DAERAH PEMILIHAN DALAM PEMILIHAN UMUM LEGISLATIF MENURUT UNDANG-UNDANG DASAR NEGARA REPUBLIK INDONESIA TAHUN 1945
Authors: Hantoro Bimo Fajar
Published: December 2024

Electoral redistricting institution has a critical role in determining whether a proportional arrangement of electoral districts can be achieved. In Indonesia, there has been a disparity between electoral districts established by the House of Representatives (DPR) and the General Elections Commission (KPU), especially during the 2019 DPR Election. Using doctrinal and socio-legal approaches, this paper aimsto evaluate the prospect of establishing a separate boundary commission in accordance with the 1945 Constitution. The findings suggest that the establishment of a boundary commission as part of electoral management bodies is normatively feasible. However, it must meet the institutional requirements of being national, permanent, and independent. Independency has to be construed as the institution being impartial. By conferring the boundary delimitation authority to a boundary commission, not only would KPU's burden be reduced, it could also better ensure that the delimitation process adheres to the delimitation principles.
PROBLEMATIKA PENGEMBANGAN BAHASA UNTUK MASYARAKAT DAERAH
Authors: Purnamasari Hetty
Published: December 2024

Pendidikan di Indonesia saat ini menghadapi masalah dengan pendidikan yang berhubungan erat dengan perkembangan kebutuhan masyarakat dalam dunia kerja. Adapun lulusan yang dibutuhkan saat ini adalah lulusan yang memiliki kompetensi unggul tidak hanya dalam ketrampilan kerja di dunia industri tetapi juga kemampuan berpikir atau lulusan yang berorientasi pada kerja pikiran. Sedangkan sebagian masyarakat di daerah-daerah masih banyak yang menutup diri dengan adanya sebuah budaya baru, bahasa baru, media baru yang semakin berkembang.Melalui pembelajaran bahasa pengetahuan baru dan upaya persuasif bisa dilakukan. Diterimanya bahasa baru atau bahasa kedua di sebuah komunitas tertentu sering mengalami banyak hambatan, terutama pada sikap masyarakat yang cenderung tertutup. Upaya mengenalkan bahasa kedua dalam sebuah komunitas masyarakat yang agak tertutup dapat dilakukan melalui media teater rakyat yang dimiliki masyarakat tersebut. Selain itu, melalui pembentukan komunitas baru terutama pada anak-anak di sekolah. Dengan guru yang sudah berlatar belakang dwi bahasawan dan mampu membuat siswa aktif untuk menggunakan bahasa kedua, upaya pengembangan bahasa dan pengetahuan akan lebih mudah.
Diksi Dan Gaya Bahasa pada Naskah Pidato Presiden Soekarno
Authors: Hardianto Musa , Widayati Wahyu , Sucipto Sucipto
Published: December 2024

Dalam penelitian ini, peneliti menganalisis diksi dan gaya bahasa pada pidato Presiden Soekarno. Tujuan dari penelitian ini adalah untuk mendeskripsikan penggunaan diksi dan gaya bahasa pada pidato Presiden Soekarno. Penelitian ini bersifat deskriptif kualitatif. Metode yang digunakan adalah analisis isi. Sumber data berupa dokumen berupa pidato Presiden Soekarno. , yaitu: (1) reduksi data; (2) penyajian data; (3) menarik kesimpulan. Hasil yang didapat adalah jenis diksi dan gaya bahasa yang terjadi dalam pidato Presiden Soekarno. Pilihan kata-kata dan gaya bahasa dalam iklan kampanye digunakan untuk menarik pendengar / simpati masyarakat untuk mewujudkan gagasan kebangsaan. Dalam penelitian ini, diksi yang paling banyak digunakan adalah kata abstrak dan kata konkret. Ini karena dalam pidato Presiden Soekarno banyak yang mengungkapkan program, visi, misi berupa gagasan atau gagasan yang menjadi indikator kata abstrak Sedangkan penggunaan kata-kata konkret terjadi karena dalam teks pidato juga menyampaikan fakta-fakta di bentuk benda yang diamati. Gaya bahasa yang terkandung dalam naskah pidato berdasarkan pilihan kata meliputi gaya bahasa formal, gaya bahasa tidak resmi, dan gaya percakapan bahasa. Gaya bahasa berbasis nada mencakup gaya sederhana, gaya mulia dan kuat.Kata kunci: Kamus, Gaya Bahasa, naskah pidato
ARTIFICIAL INTELLIGENCE, CHESS AND THE RISKS OF MODERN CIVILIZATION
Authors:   Lugansk Voroshilov State Agricultural University, Lugansk, Russia, Pilavov G. Sh.
Published: December 2024

Currently, the field of artificial intelligence is one of the most intensively developing areas of modern science. The subject of the article is an actual problem related to the intensive development of artificial intelligence. The purpose of the work is to identify possible problems in this matter and propose ways to resolve them. The work uses a sociosymmetric approach, according to which a similar problem is investigated, actualized in the space of chess. The methodological basis of the research is extrapolation, which allows applying the method of artificial intelligence in the socio-cultural space. The opinions of modern scientists and philosophers on this issue are analyzed. It is shown that the scenario of artificial intelligence getting out of control of mankind, which is so popular in the field of culture, is unlikely to pose a real danger to our civilization. The current problems related to the development of computer technologies in chess are considered. This approach is due to the fact that chess is largely a reflection of the actual socio-cultural issues. It was revealed that the appearance of chess programs that surpass the strength of people did not lead to any negative problems in the chess space. Thus, the thesis is confirmed that strong artificial intelligence in itself does not pose any real threat to humanity. At the same time, an appeal to chess topics shows that one of the most pressing problems in chess – related to the development of computer technology – is cheating – the use of chess programs to achieve victory dishonestly. The connection between cheating in chess and the possibility of using similar technologies on a global scale has been revealed, which is highly likely to lead to a civilizational crisis. As the researchers of this issue have noted, artificial intelligence can be used as a tool to establish an autocratic regime (Wang Jianguang), or become a means for radical socio-political processes (G. I. Kolesnikova). In conclusion, proposals are put forward on the most effective methods of combating the possible use of artificial intelligence to radically change the vector of development of our civilization. In our opinion, they should include the methodologies of transhumanism and the philosophy of technology, thus creating an interdisciplinary approach to the philosophy of artificial intelligence.
DIGITAL INEQUALITY AS A NEW FORM OF SOCIAL INEQUALITY
Authors:   Udmurt State Agricultural University, Izhevsk, Russia, Platonova S. I.
Published: December 2024

The relevance of the article is associated with the active development of digital technologies and the emergence of digital inequality as a new form of social inequality. The article considers the socio-philosophical aspects of digital inequality. The methodological basis of the study is general logical methods of analysis, generalization, comparison, classification, typification. The study used the principles of dialectical and systemic approaches: development, comprehensiveness of study, historicism. Attention is drawn to the fact that there are empirical studies of digital inequality, which consider the levels of digital inequality (global, social, individual), the evolution of forms of digital global inequality. However, a consistent socio-philosophical analysis of digital inequality, offering a theoretical basis and a categorical-conceptual apparatus for understanding this phenomenon, is not presented in scientific knowledge. Currently, there is no unified approach to the concepts of «digital inequality» and «digital capital». There is a need for a general definition of these concepts, which should serve as a starting point for further research of digital inequality and digital capital. Digital inequality exists in various forms related to access to the latest information technologies, the use of information and communication technologies, and social prospects for mastering ICT. The manifestation of digital inequality in the main spheres of society is considered: political, economic, social, and spiritual. Attention is drawn to the connection and interdependence of digital inequality and digital capital. Based on the theory of social capital and the concept of «habitus» by P. Bourdieu, the process of converting digital capital into other forms of capital is studied. The article shows that all types of capital are interconnected and an individual with economic, political, personal, and cultural capital can transform them into digital capital (the ability and skills to use the Internet). Digital capital, in turn, is converted into offline capital. It is concluded that the lack or limitation of access to the digital environment, a low level of digital competencies is one of the main sources of the development of digital inequality as a type of social inequality in a digital society. The article also draws attention to the need to take into account the social and cultural characteristics of individuals when studying the formation of digital capital and digital inequality. A conclusion is made about understanding digital inequality as an integral phenomenon associated with digital capital.
Detection of transmembrane protein 100 in breast cancer: Correlation with malignant progression and chemosensitivity
Authors: Liu Xiao , Zhang Guiqian , Zhao Ling
Published: December 2024

Objective:

With increased incidence, breast cancer has become the most common malignant tumor in women. Transmembrane protein 100 (TMEM100) is a key factor affecting the progression of malignant tumors. The aim of the study is to examine the molecular mechanism of TMEM100 in malignant progression.

Material and Methods:

TMEM100 expression was analyzed by Western blot, immunohistochemistry, and real-time quantitative polymerase chain reaction. Cell migration and invasiveness after transfection with TMEM100 were investigated by Transwell assay. 5-ethynyl-2-deoxyuridine staining and cell colony-formation assay were utilized to the exploration of cell proliferation. Flow cytometry was adopted to detect whether TMEM100 affected the effect of Docetaxel on cell apoptosis. The effects of TMEM100 on the Ras-extracellular signal-regulated kinase (RAS/ERK) pathway were explored by Western blot assay.

Results:

Downregulated TMEM100 expression was in breast cancer tissues (P < 0.01). TMEM100 overexpression hindered the invasion (P < 0.01), migration (P < 0.01), and proliferation (P < 0.01) of breast cancer cells. Chemotherapy sensitivity of breast cancer cells to docetaxel was enhanced by TMEM100 (P < 0.01). TMEM100 inhibited Ras expression and ERK1/2 phosphorylation (P < 0.01). Furthermore, ERK agonist TertButylhydroquinone neutralized the effects of TMEM100 (P < 0.01).

Conclusion:

TMEM100 blocked malignant progression of breast cancer and enhanced docetaxel chemosensitivity by suppressing RAS/ERK pathway. These data manifested that regulation of TMEM100 expression may affect the progression of breast cancer, and its prognostic value and mechanism deserve further investigation.
Deciphering the synergistic role of tyrosyl-tRNA synthetase 1 and yes-associated protein 1: Catalysts of malignant progression in hepatocellular carcinoma
Authors: Zhou Lifang , Zhang Xin , Zhang Chongyang , Wang Yu , Zhang Jiaju , Wang Yunxia , Sui Yongbo
Published: December 2024

Objective:

Hepatocellular carcinoma (HCC) represents a severe and aggressive malignancy with a poor prognosis, characterized by high incidences of illness and death, making it a critical issue for global health. Tyrosyl-tRNA synthetase 1 (YARS1) is known to be upregulated across various cancers and is considerably linked to tumorigenesis. However, the detailed functions and molecular mechanisms of YARS1 in HCC remain unclear. This research explores the expression of YARS1 in HCC and its role in promoting tumor progression through the yes-associated protein 1 (YAP1) pathway.

Material and Methods:

The potential role and diagnostic significance of YARS1 and YAP1 in HCC were analyzed using relevant datasets. Subsequently, we constructed HCC cell lines with stable knockdown or overexpression of YARS1. In vitro, we used Cell Counting Kit-8 and colony formation assays to examine cell proliferation, terminal deoxynucleotidyl transferase dUTP nick end labeling assays to detect apoptosis, and Transwell migration and invasion assays to assess cell metastasis. Western blotting was employed to analyze the molecular mechanisms. Finally, we developed a lung metastasis model for HCC to assess the impact of YARS1 and YAP1 on tumor spread in a living organism, as well as their interrelationship.

Results:

The findings revealed a notable increase in YARS1 expression in HCC tumors, associated with a worse prognosis. In vitro, YARS1 overexpression significantly increased HCC cell proliferation and metastasis when reducing apoptosis (P < 0.001). In addition, YARS1 overexpression accelerated HCC growth in vivo. Further experiments demonstrated that silencing YAP1 effectively reversed the effects of YARS1 on HCC cell invasion (P < 0.01), apoptosis inhibition (P < 0.01), and metastasis (P < 0.001).

Conclusion:

In summary, this research reveals that YARS1 enhances the malignant progression of HCC through the activation of the YAP1 signaling pathway. Elevated levels of YARS1 in HCC are strongly linked to poor prognosis, indicating that YARS1 might serve as a new therapeutic target for HCC. Future studies should investigate additional mechanisms of YARS1 in HCC and create targeted therapies to improve outcomes for HCC patients.
Soluble Urokinase Plasminogen Activated Receptor in Type 2 Diabetes Mellitus Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Interventional Cohort Study
Authors: Prakash Mohit , Mujahid Omer Mohammed , Choudhury Minati
Published: December 2024

Objectives:

Elevated levels of soluble urokinase plasminogen activator receptor (suPAR) increase mortality in various systemic diseases. This has been shown amply in recent literature. The primary aim of the study was to investigate that whether this increase in suPAR levels have same results in type 2 diabetes mellitus (T2DM) patients undergoing coronary artery bypass grafting (CABG). We also aimed to observe the duration of mechanical ventilation and length of stay in the intensive care unit in these patients as our secondary aim.

Materials and Methods:

Blood samples of adult patients having T2DM admitted for elective on-pump CABG surgery were collected after induction of anesthesia before skin incision (T1) and 48 h post-cardiopulmonary bypass (CPB) (T2) from the year 2022 to 2023. The study was conducted on 196 patients of either sex of age at least 18 years with T2DM with the American Society of Anesthesiologists status III to IV. Patients were randomly divided into 2 groups with alternative allocation. Patients of the study group (n = 96) were measured suPAR, high-sensitivity C-reactive protein (hsCRP), and blood sugar, while patients of the control group (n = 100) were measured hsCRP and blood sugar only. Threshold suPAR levels for predicting mortality in the immediate post-operative period were assessed through receiver operating characteristic curves and optimal values decided using Youden’s Index.

Results:

There was a significant rise in suPAR and hs-CRP levels before the start of surgery and 48 h post-CPB (P < 0.001).

Conclusion:

In patients with T2DM undergoing on-pump CABG, increased pre-bypass, and especially 48-h post-CPB, levels of suPAR and hsCRP predict more mortality.
Intermetallic Materials for High-Capacity Hydrogen Storage Systems
Authors: Pavlyuk Nazar , Kordan Vasyl , Dmytriv Grygoriy , Yarema Maksym , Pavlyuk Volodymyr
Published: December 2024

In this article, we provide an overview of hydrogen storage materials, taking our previous results as examples. Towards the end of the paper, we present a case study in order to highlight the effects of substitutional alloying, compositional additives, and nanostructuring on the hydrogen sorption properties of magnesium-based intermetallics. Specifically, partial substitution of Mg by Li and d-elements by p-elements leads to structural changes, inducing disorder and the formation of high-entropy alloys. Our approach showcases the methodology to enhance the H2-capacity and to provide a positive boost to the H2-storage performance, including lower temperatures of H2 desorption, better thermodynamics and kinetics, lower temperatures of hydrogen uptake/ release for Metal-Hydride Hydrogen Storage (MHHS) systems and higher capacity of anodes for Metal-Hydride batteries (MHB) together with lower prices of raw materials.
КСИЛОТОМИЧЕСКАЯ ХАРАКТЕРИСТИКА СПИРЕИ ЗВЕРОБОЙНОЛИСТНОЙ - SPIRAEA HYPERICIFOLIA L. (ROSACEAE) ИЗ ИТУМКАЛИНСКОЙ АРИДНОЙ КОТЛОВИНЫ
Authors: Умаров М.У. , Чавчавадзе Е.С. , Сизоненко О.Ю. , Волкова С.Б.
Published: December 2024

Изучены анатомические характеристики древесины 10 особей спиреи зверобойнолистной - Spiraea hypericifolia L. (сем. Rosaceae) из Итумкалинской аридной котловины (Восточный Кавказ). Отмечены её структурные особенности, количественные параметры и изменчивость гистологических элементов. По степени изменчивости в пределах образца древесины выделены три группы признаков - с низким (12 признаков из 18), средним (4) и очень высоким (2) уровнем варьирования. Изменчивость большинства признаков (за исключением плотности сосудов, объема многорядных лучей, суммарного объема лучевой ткани и объема порозности древесины) в переделах одного местообитания выше, нежели внутри образца древесины. Многовариантность проявления количественных признаков, способность их варьирования, наряду со сложившимся набором качественных ксилотомических признаков, расширяя экологическую амплитуду вида, позволяют ему поселяться в различных биотопах аридной котловины.

Anatomical characteristics of wood of 10 individuals of Spiraeahypericifolium - Spiraea hypericifolia L. were studied. (Rosaceae) from the Itumkalinsky arid basin (Eastern Caucasus). Marked by its structural features and quantitative parameters and the variability of the histological elements. According to the degree of variability within the wood sample, three groups of characteristics are identified - with a low (12 out of 18 features), medium (4) and very high (2) level of variation. The variability of most features (with the exception of vascular density, multi-row ray volume, total ray tissue volume, and wood porosity volume) in one habitat is higher than within a wood sample. The multivariance of quantitative traits, their ability to vary, along with the existing set of qualitative xylotomic traits, expanding the ecological amplitude of the species, allow it to settle in various biotopes of the arid basin.