bluuebunny/crossref_metadata_2025 huggingface dataset:
Erroneous Electrocardiographic Interpretations and its Clinical Implications
Authors: Shaik Ayesha , Patel Nirav , Alvarez Chikezie , Panza Gregory , Baker William , McMahon Sean , Kluger Jeffrey
Published: April 2023

Introduction: The advancement of artificial intelligence (AI)
has aided clinicians in the interpretation of electrocardiograms (ECGs)
serving as an essential tool to provide rapid triage and care. However,
in some cases, AI can misinterpret an ECG and may mislead the
interpreting physician. Therefore, we aimed to describe the rate of ECG
misinterpretation and its potential clinical impact in patient’s
management. Methods: We performed a retrospective descriptive
analysis of misinterpreted ECGs and its clinical impact from May 28,
2020 to May 9, 2021. An electrophysiologist screened ECGs with confirmed
diagnosis of atrial fibrillation (AF), sinus tachycardia (ST), sinus
bradycardia (SB), intraventricular conduction delay (IVCD), and
premature atrial contraction (PAC) that were performed in the emergency
department. We then classified the misinterpreted ECGs as pseudo-AF, ST,
SB, IVCD, or PAC into the correct diagnosis and reviewed the
misinterpreted ECGs and medical records to evaluate inappropriate use of
antiarrhythmic drugs (AAD), beta-blockers (BB), calcium channel blockers
(CCB), anticoagulation, or resource utilization of cardiology and/or
electrophysiology (EP) consultation. Results: A total of 4,969
ECGs were screened with diagnoses of AF (2,282), IVCD (296), PAC (972),
SB (895), and ST (638). Among these, 101 ECGs (2.0%) were
misinterpreted. Pseudo-AF (58.4%) was the most common followed by
pseudo-PAC (14.9%), pseudo-ST (12.9%), pseudo-IVCD (7.9%) and
pseudo-SB (6.0%). Patients with misinterpreted ECGs were aged
76.6±11.6yr with male (52.5%) predominance and hypertension being the
most prevalent (83.2%) comorbid condition. The misinterpretation of
ECGs led to the inappropriate use of BB (19.8%), CCB (5.0%), AAD
therapy (7.9%), anticoagulation (6.9%) in patients with pseudo-AF, as
well as inappropriate resource utilization including cardiology (41.6%)
and EP (8.9%) consultations. Conclusions: Misinterpretation of
ECGs may lead to inappropriate medical therapies and increased resource
utilization. Therefore, it is essential to encourage physicians to
carefully examine AI interpreted ECG’s, especially those interpreted as
having AF.
An Overview on RF Energy Harvesting Techniques for Low Power Sensors in Wireless Communication Systems
Authors: prashad lal babu , Mohanta Harish Chandra , Akwafo Reynah
Published: April 2023

In the wireless communication era, radio frequencies (RF) are always
present in the surrounding environment. This availability of abundant RF
energy ignites the idea of the RF energy harvesting concept. This
concept coins the eco-friendly self-sustainable wireless communication
links between two nodes. In this paper, RF energy harvesting components
required to scavenge RF energy from ambient energy sources are reviewed
and cost-effective, environment eco-friendly with high RF to DC
conversion efficiency rectenna design challenges are also presented.
Prevalence of Human Papillomavirus and cervical lesions among women older than 64 years and outside the Chinese cervical cancer screening age in Guangzhou
Authors: Li Xiaomao , Huiyun Jiang , Yang Yuebo
Published: April 2023

The prevalence of human papillomavirus (HPV) genotype and cervical
dysplasia in women older than 64 years, who are outside the Chinese
cervical cancer screening age, has not been extensively studied. Here we
conducted a retrospective analysis of women from a tertiary hospital in
Guangzhou, aiming to provide meaningful advice for cervical cancer
prevention and control in Guangzhou, China. In this study, the
age-specific prevalence of any HPV genotypes showed a U-shaped pattern,
and the second peak was observed among women >64 years,
which was 19.27%. The top six HR HPV genotypes were HPV 16, HPV 52, HPV
58, HPV 31, HPV 33, and HPV 18. The persistence rate of any HPV in 24
months among women > 64 years was 33.33%, which was higher
than that of women among <25 years age group (20.75%), and
25-64 years age group (20.46%). For HPV-positive women aged
>64 years, the proportion of cervical cancer (16.47%) was
obviously higher than that in women aged 25-64 years (2.41%) (
P<0.001). The infection of HPV 58 was the greatest risk
factor for the occurrence of HSIL+ (OR 3.556; 95% CI, 1.107-11.415;
P=0.032) in women aged >64 years, with HPV+/NILM. In
conclusion, the burden of HPV infection in women >64 years
is heavy in Guangzhou. Re-evaluate cervical cancer screening strategies
for women after age 64 is needed. And HPV 16/18/52/58 genotype model may
be an alternative triage strategy to discover HSIL+ among women aged
>64 years, with HPV+/NILM.
Changes in soil profile organic carbon and hydro-physical properties as impacted by long-term manure and inorganic fertilizer rates under a corn-soybean-spring wheat rotation system
Authors: Sangotayo Anuoluwa , Chakraborty Poulamee , Kumar Sandeep , Kovács Péter
Published: April 2023

Using manure appropriately can enhance organic carbon, and
hydro-physical properties without negatively impacting the environment.
However, how manure impacts soils, especially at deeper depths, is still
not well studied. Therefore, the objective of this study was to assess
the impact of different manure and inorganic fertilizer application
rates on soil profile organic carbon and hydro-physical properties under
corn(Zea mays L.)-soybean(Glycine max L.)-spring wheat (Triticum
aestivum L) rotation at Beresford (initiated, 2003) and Brookings (2008)
sites in South Dakota. Treatments included: low manure(LM), medium
manure(MM), high manure(HM), medium fertilizer(MF), high fertilizer(HF),
and control(CK). Four replicated intact soil cores were collected from
all the treatments at 0-10, 10-20, 20-30, and 30-40 cm depths.
Considering treatments by depth interactions, the HM increased the SOC
and TN stocks by 16-62% as compared to the CK, MF, and HF at 0-10 cm
for either site. However, treatments did not always impact these
parameters beyond 20 cm depth. On observing treatment as the main
effect, the MM and HM increased the SWR at 0, -5 kPa compared to MF, HF,
and CK in Brookings, and the MM increased the SWR at -30 kPa as compared
to the MF in Beresford at 0-40 cm depths. Data suggests continuous
manure application may enhance organic carbon and hydro-physical
properties at deeper depths. Therefore, this study concluded that
long-term manure application is more beneficial when you consider the
application rate and its timing. It can improve hydro-physical
properties, thereby stabilizing the soil structure and improving water
retention at deeper depths.
Triacontane and Behenyl Lignocerate Molecular Tilting in Crystals: Theory, Monte Carlo Simulations and Predictions
Authors: Cooney Joseph , Martini Silvana , Pink David , Peyronel Fernanda
Published: April 2023

Oleogelators are molecules that, when combined with edible oils can form
semi-solid materials. Although many molecules have been tried as
oleogelators in the last 20 years, much is still unknown. Here, the
molecular structure of two possible oleogelators: triacontane (TC) and
behenyl lignocerate (BL) were studied using a mathematical model for
each molecule and carrying out computer simulation using the Metropolis
Monte Carlo (MMC) algorithm in which the only interaction is via
Lennard-Jones dispersion forces. The computer simulation explored the
possibility of having either rigidly-extended molecules or twisted ones
via the formation of gauche bonds. The results showed that both TL and
BL molecules create a monolayer that did not include any gauche bond so
that all molecules were effectively rigidly extended. The effective
thickness of the monolayer was compared with experimental data and with
the predictions of Peyronel et al. (in review) which assumed that the
molecules were rigidly-extended. The work reported here justified that
assumption. The conclusion was that the TC and BL molecules must be
packed with a tilt angle in relation to the methyl group plane to match
the experimental data. The angle of TC tilt was calculated to be
~27° which essentially confirms that reported by
Peyronel et al. (in review).
Experiential Avoidance as a Mediator of Risk Factors for Higher Order Internalizing Psychopathology in the Perinatal Period
Authors: Jiang Lily J. , Miller Michelle L. , O'Hara Michael
Published: April 2023

Objectives: Perinatal psychopathology can be damaging. This
study examined the strength of the associations between risk factors and
all perinatal mood and anxiety disorder symptoms while assessing the
mediating effect of experiential avoidance. Method:
Participants ( N =246) completed assessments during pregnancy
(28-32 weeks) and the postpartum (6-8 weeks). Structural equation
modeling (SEM) was used to examine associations between risk factors and
latent factors: Distress (composed of depression, generalized anxiety,
irritability, and panic symptoms); Fear (social anxiety, agoraphobia,
speciﬁc phobia, and obsessive-compulsive); and Bipolar (mania and
obsessive-compulsive). Results: During pregnancy, past
psychiatric history, anxiety sensitivity, maladaptive coping, and age
were significant risk factors. In the postpartum, negative maternal
attitudes and past psychiatric history were only risk factors for
symptoms that composed Distress. Experiential avoidance mediated the
relation between maladaptive coping and symptoms that composed Fear.
Conclusion: It is important to assess for psychological risk
factors starting in pregnancy. This study identified critical risk
factors that are associated with the underlying commonality among
perinatal mood and anxiety symptoms. Some of the risk factors as well as
the mediator are malleable (negative maternal attitudes, experiential
avoidance), creating new possibilities for prevention and treatment of
perinatal mood and anxiety disorder symptoms.
Cost Analysis of Orthoptist-Led Neurofibromatosis Type 1 Screening Clinics
Authors: Kaur Navdeep , Lewis Catherine , Staffieri Sandra , Ruddle Jonathan , Goranitis Ilias , Stiles Jay , Dabscheck Gabriel
Published: April 2023

Purpose: To conduct a costing study comparing orthoptist-led with consultant-led clinics screening for optic pathway gliomas (OPGs) in children with neurofibromatosis Type 1 (NF1) attending the Royal Children’s Hospital (RCH), Melbourne.
Methods: Patients with NF1 examined in the orthoptist-led NF1 screening clinic and/or consultant-led clinics during the study period were identified. The workflow management software Q-Flow 6® provided data documenting patient’s time spent with the orthoptist, nurse, and ophthalmologist. Time points were converted into minutes and multiplied by the cost-per-minute for each profession. A bottom-up micro-costing approach was used to estimate appointment level costs. Bootstrap simulations with 1000 replications were used to estimate 95% confidence intervals (CIs) for the difference in mean appointment time and cost between clinics.
Results: Data for 130 consultant-led clinic appointments and 234 orthoptist-led clinic appointments were extracted for analysis. The mean time per appointment for the consultant-led clinic was 45.11 minutes, and the mean time per appointment for the orthoptist-led clinic was 25.85 minutes. The mean cost per appointment for the consultant-led clinic was A $84.15 (GBP £39.60) compared to the orthoptist-led clinic at A $20.40 (GBP £9.60). This represents a mean reduction of 19.25 minutes per appointment (95% CI, –24.85 to –13.66) and a mean reduction of A $63.75 (GBP £30.00) per appointment (95% CI, (A $-75.40 to $-52.10 [GBP £ -35.48 to £ -24.52]).
Conclusion: An orthoptist-led clinic screening for OPGs in patients with NF1 can be a more cost-efficient model of care for ophthalmic screening in this patient group.
Sustainable forest management in SE “Srbijashume” status and potential, through the example of the good prask of “Stara Planina” nature park
Authors: Bakovic Zvonimir , Kisin Bratislav , Vasic Vladimir , Kosanin Olivera
Published: April 2023

This paper aims to present the potentials, condition of forests, basic
business principles and development strategy of SE ?Srbijasume?, which is
primarily in the function of sustainable forest management. Applied forest
management systems will be evaluated based on measurable parameters: time,
area, wood volume, volume increment. The concept of sustainable forest
management in PE ?Srbijasume? is planned and implemented in protected
natural resources as well. The paper analyzes the Nature Park (NP) ?Stara
planina?, which was chosen based on two facts: that it is part of the
ecologically significant area ?Stara planina? of the ecological network of
the Republic of Serbia and that according to the IUCN it belongs to the 5.
category of protected areas. The sustainability of forest management in NP
?Stara planina? was analyzed on the forested areas owned by the state, which
are managed by SE ?Srbijasume? in relation to the functions of forests,
purpose of space, time, area, wood volume and volume increment. The paper
recommends long-term goals of sustainable forest management that can serve
as models for other protected areas in Serbia.
Silviculture in deteriorated stand conditions and complex societal demands in the area of National Park "Fruska Gora"
Authors: Bobinac Martin , Grozdanic Djordje , Andrasev Sinisa , Susic Nikola
Published: April 2023

The application of silviculture measures on contemporary, rationalized basis in order to sustain and improve forests in the area of the National park ?Fruska Gora?, is the most im?portant segment of forest management, having in mind their anthropogenically deteriorated conditions and their purpose. For the improvement of stand conditions, intensive silvicultural tending measures are necessary in certain phases of development of the stands which is con?trary to the passive protection. The main reasons for the application of these measures are in the coppice origin of the stands on over 82% of the area of National park and the silver lime dominance compared to other edificators (oaks and beech). On the basis of the ecosystem approach in forest management, and especially in conditions of more pronounced climate change, the silvicultural measures need to be rationally synchronized with biological-ecological demands of the main species and dominant processes in forest ecosystems. In other words, there is a need to implement the elements of close-to-nature forest management. This paper points toward the most important determinations of silviculture in order to achieve the goals of special-purpose forests in the National park.
Sustainable management of the National Park Kopaonik - opportunities and challenges
Authors: Nonic Dragan , Sumarac Predrag , Rankovic Nenad , Djordjevic Ilija , Nedeljkovic Jelena
Published: April 2023

The management of the National Park (NP) Kopaonik is entrusted to the Public
En?terprise (PE) ?NP Kopaonik?, which represents a delegated form of ?state
management? in the public sector. The paper aims to study the most important
elements of the management organization of NP Kopaonik. Regulatory and
institutional frameworks, internal organization and financing mechanisms for
the management of NP Kopaonik were discussed. The purpose of the research is
to determine the possibility of improving the organization and financing of
NP Kopaonik towards sustainable management. Primary data was collected by
conducting interviews with representatives of management and stakeholders.
In terms of improving the internal organization of PE ?NP Kopaonik?, it was
proposed to form additional organizational units, i.e. services for visitor
management, promotion, cooperation with the media and market?ing, provision
of tourist offers, preparation and implementation of projects and
international cooperation, as well as the improvement of hunting and
fishing. It was emphasized that these tasks are already performed within the
PE ?NP Kopaonik? but also that it is necessary to make certain changes in
the organizational structure and strengthen personnel and financial
capacities, which would affect the quality of these activities.
Forest management in the first level of protection at the Special Nature Reserve “Obedska Bara”
Authors: Tubic Bojan , Radjevic Vid , Marinkovic Marko , Vasic Ivana , Petrovic Nenad
Published: April 2023

The oak forests in the area of the Special Nature Reserve ?Obedska bara? are
extremely valuable and unique at the national and European level, which is
why they are recognized as the fundamental value of the reserve. The local
name of the oldest complex of oak forests in the special nature reserve is
?Debela gora rainforest? and it has been placed in the first degree of
protection regime. Given that it is included in the first level protection
regime, the priority goal of forest management is the preservation of
biological diversity, which implies the absence of any management
treatments. As a result of this approach, there is a loss of oaks and other
species with higher demands for light, therefore other species such as
hornbeam appear and take over, which is subject of analysis in this paper.
Given that the replacement of species is not the goal of forest management
in areas under the first degree of protection, this paper proposes forest
management protective measures aimed at the restoration and revitalization
of areas that could be implemented with the consent of the competent
institutions.
Rethinking Soviet Era mass housing in Kazakhstan
Authors: Sarzhanov Niyaz , Schurch Thomas
Published: April 2023

Mass high-rise, tenement housing in former Soviet bloc countries, built within the modernist genre, has proved to be problematical throughout the history of architecture and urban planning. This study addresses features of mass housing in the former Soviet state of Kazakhstan, in which planning, artistic, psychological, social, and urban aspects of housing have resulted in the inhabitants? diminished quality of life. The study?s findings reveal specific critical problems regarding typical tenements in Kazakhstan for their inhabitants and for the urban environments they occupy. An interdisciplinary approach reveals both negative and positive characteristics of various types of Kazakh mass tenement housing, with an emphasis on the former. The paper addresses some potentialities and recommendations for renovation that would enhance the quality of life in the urban setting.
Guillain-Barre Syndrome in a Patient Posted for Elective Caesarean Delivery: An Anaesthetic Dilemma
Authors: SK Shenoy
Published: April 2023

Guillain-Barre syndrome (GBS) is an acute polyneuropathy most commonly associated with acute flaccid paralysis which may be associated with sensory and autonomic neuropathy. Antecedent infection may trigger an immune response which may cause a cross reaction leading to demyelination and degeneration of axons in nerves. Here we present a case of a 28 year old female, G2P1 at 37 weeks of gestation with a history of previous lower segment caesarean section (LSCS) and oligohydramnios with suspected Guillain-Barre syndrome posted for elective LSCS. She presented with dribbling of saliva from angle of mouth and inability to close both eyes with slurring of speech since 2 days. MRI brain was advised which showed no specific changes. Neurology evaluation was done and Guillain-Barre syndrome with isolated facial diplegia was suspected. Due to risks associated with general anaesthesia and succinylcholine in this patient, a decision was made to proceed with a low dose spinal anaesthesia. Once administered, the level of subarachnoid block was noted to be at T6. The caesarean section proceeded uneventfully with no major hemodynamic changes. A healthy baby girl was delivered and patient was noted to have full motor and sensory recovery in the post-operative period. Providing anaesthesia to patients with Guillain-Barre syndrome can be very challenging. Meticulous pre-anaesthetic planning is needed. A thorough pre-anaesthetic evaluation considering risks and benefits of each modality of anaesthesia is crucial before anaesthetizing these patients.
DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS)
Authors: Zahra Azalia Talitha , Saleh M. Irsan , Hafy Zen , Effendi Yusuf , Maritska Ziske , Liberty Iche Andriyani
Published: April 2023

ABSTRACT

Classic symptoms of PCOS including irregular menstruation, high serum androgen concentration, hirsutism, and infertility or subfertility. Low serum sex hormon binding globulin (SHBG) may cause increase of free serum androgen which in turn may cause ovarian dysfunction and clinical symptoms associated with hyperandrogenism. This study aims to look the difference of serum SHBG concentration in PCOS patients and healthy control in Palembang, South Sumatra. This was a case-control study involved 36 PCOS patients and 36 healthy controls. Patient serum was collected and SHBG concentration was conducted using ELISA according to manufacturer instruction. Median serum SHBG concentration in PCOS case group was 152.524 nmol/L (min. 5.756 nmol/L, max. 1539.383 nmol/L). meanwhile, median serum SHBG concentration in control group was 971.449 nmol/L (min. 114.479 nmol/L, max. 1944.036 nmol/L). The difference was found to be statistically significant, with p < 0.001 according to Mann-Whitney test. It is to be concluded that serum SHBG concentration is significantly lower in PCOS patient group compared to healthy control.

ABSTRAK

Gejala khas PCOS berupa berupa haid tidak teratur, kadar androgen serum yang tinggi, hirsutisme, dan infertilitas atau subfertilitas. Kadar sex hormon binding globulin serum yang rendah menyebabkan peningkatan kadar androgen bebas di serum yang dapat menyebabkan disfungsi ovarium dan gejala klinis yang terkait hiperandrogenisme. Penelitian ini bertujuan untuk melihat perbedaan kadar SHBG serum pada pasien PCOS dan kontrol sehat di Palembang, Sumatra Selatan. Penelitian ini menggunakan metode case control dengan sampel 36 pasien PCOS dan 36 kontrol sehat. Serum darah pasien diambil dan kadar SHBG diperiksa menggunakan ELISA sesuai instruksi pembuat. Kadar SHBG median pada kelompok kasus PCOS adalah 152,524 nmol/L (min. 5,756 nmol/L, maks. 1539,383 nmol/L). sementara itu, kadar SHBG median pada kelompok kontrol adalah 971,449 nmol/L (min. 114,479 nmol/L, maks. 1944,036 nmol/L). Perbedaan tersebut bermakna secara statistik dengan p< 0,001 dengan uji Mann-Whitney. Dapat disimpulkan bahwa kadar SHBG serum pada subjek dengan PCOS lebih rendah secara bermakna dibandingkan dengan kelompok kontrol.
KEMAMPUAN EKSTRAK ETANOL DAUN KELOR (Moringa oliefera) DALAM MENGHAMBAT PEMBENTUKAN BIOFILM Escherichia coli
Authors: Hutomo Suryani , Anggreni Ni Wayan Rosa , Larope Ceny Gloria , Trismalinda Ni Wayan Maitri Puspadi , Sari Ni Komang Ayulia , Sooai Christiane Marlene
Published: April 2023

ABSTRACT

Escherichia coli is a Gram-negative bacterium which is the main etiologic of urinary tract infection. This species adheres on host tissue and forms biofilm as one of its virulence factors. The increasing cases of antibiotics resistance towards this bacterium causes to develop methods to control E. coli biofilm formation. Kelor (Moringa oliefera) leaves have known to be an antibiotic. The aim of this study is to analyze the ability of kelor leaves extract to inhibit E. coli adherence. Kelor leaves were extracted with the maceration method. The susceptibility of E. coli to this extract was examined by a minimum inhibitory concentration (MIC) test using the broth microdilution method. A bacterial adherence assay was performed by similar methods of the MIC assay. The MIC value for the kelor leaves extract was at a concentration of 5,000 μg/ml. Moreover, this extract inhibited E. coli adherence starting at a concentration of 125 μg/ml and reached a maximum at a concentration of 2,000 μg/ml. Statistical analysis using One-way Anova demonstrated a significant difference of E. coli adherence following stimulation with kelor leaves extract (p = 0.000). In conclusion, kelor leaves extract can inhibit E. coli biofilm formation.

ABSTRAK

Escherichia coli merupakan bakteri Gram negatif penyebab utama infeksi saluran kemih. Kemampuan bakteri ini untuk melekat pada host dan membentuk biofilm merupakan salah satu faktor virulensinya. Adanya resistensi antibiotik pada bakteri ini menyebabkan perlunya dikembangkan metode untuk mengendalikan pembentukan biofilmnya. Daun kelor (Moringa oliefera) diketahui memiliki sifat antibakteri. Tujuan penelitian ini adalah untuk menganalisa kemampuan ekstrak etanol daun kelor dalam menghambat perlekatan E. coli. Pembuatan ekstrak menggunakan metode maserasi. Konsentrasi hambat minimal (MIC) ditentukan dengan metode broth microdilution. Uji anti perlekatan dilakukan dengan metode yang sama. MIC ekstrak daun kelor terdapat pada konsentrasi 5000 µg/ml. Penghambatan perlekatan dimulai pada konsentrasi 125 µg/ml dan mencapai maksimum pada konsentrasi 2000 µg/ml. Analisis statistik menggunakan One-way Anova menunjukkan perbedaan yang bermakna dari perlekatan E. coli setelah dipapar ekstrak daun kelor (p = 0,000). Kesimpulan penelitian ini bahwa ekstrak etanol daun kelor dapat menghambat pembentukan biofilm E. coli.
STUDI KOMPARATIF INVITRO AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL, FRAKSI ETIL ASETAT DAN ISOLAT AKTIF KULIT DELIMA (PUNICA GRANATUM L.)
Authors: Wahyuni Sri , Mahmuda Iin Novita Nurhidayati , Maryati  , Perdana Aditya Putra , Azizah Maharotullaili Nur
Published: April 2023

ABSTRACT

Pomegranate (Punica granatum L) is widely used for health. Pomegranate peel is part of the pomegranate fruit which is often discarded and has not been widely used. Pomegranate peel is thought to contain antioxidants. One of the examinations for antioxidants is the 1,1 dipheyl-2-picrylhydrazyl (DPPH) method, by calculating the IC50 value, where the smaller the IC50 value means that the stronger of antioxidant potential. The purpose of this study was to compare the antioxidant activity of the ethanol extract, ethyl acetate fraction, and the active isolate from pomegranate peel. The antioxidant potency was tested using the DPPH, using the UV-Vis spectrophotometer, at 515 nm wavelength. Isolation of isolates was carried out by column chromatography shepadex and TLC with toluene as mobile phase; ethyl acetate : formic acid : methanol, with a ratio of 3:3:0.8:0.2. The purity of the isolate was detected by HPLC, with water-methanol as the mobile phase. The research results showed that 96% ethanol extract, ethyl acetate fraction and active isolate from pomegranate peel have potential as antioxidants with IC50 4.52 ± 0.00, 2.71 ± 0.01, and 0.979 x 10-5 ± 0.00 µg/mL, respectively, the positive control was vitamin C, had an IC50 3.66 ± 0.02 µg/mL. The conclusion of this study is that pomegranate peel isolate has the strongest antioxidant potential, compared to 96% ethanol extract and the ethyl acetate fraction of pomegranate peel, and even vitamin C.

ABSTRAK

Delima (Punica granatum L) banyak dimanfaatkan untuk kesehatan. Kulit delima merupakan bagian dari delima yang sering kali dibuang dan belum banyak dimanfaatkan. Kulit delima diduga memiliki kandungan antioksidan. Salah satu pemeriksaan antioksidan adalah dengan metode 1,1 dipheyl-2-picrylhydrazyl (DPPH), dengan menghitung nilai IC50, dimana semakin kecil nilai IC50 dapat diartikan bahwa semakin kuat potensi antioksidannya. Tujuan dari penelitian ini adalah untuk membandingkan aktivitas antioksidan dari ektrak etanol, fraksi etil asetat, dan isolat aktif kulit delima. Potensi antioksidan diuji dengan metode DPPH, dengan menggunakan spektrofotometer UV-Vis, pada panjang gelombang 515 nm. Isolasi isolat dilakukan dengan kromatografi kolom shepadex dan KLT dengan fase gerak toluene: etil asetat: asam format: metanol, dengan perbandingan 3:3:0.8:0.2. Kemurnian isolat di deteksi dengan HPLC, dengan fase gerak air-metanol. Hasil peneiltian menunjukan bahwa ekstrak etanol 96%, fraksi etil asetat dan isolat aktif dari kulit delima memiliki potensi sebagai antioksidan, dengan nilai IC50 masing-masing sebesar 4,52 ± 0,00; 2,71 ± 0,01; dan 0,979 x 10-5 ± 0,00 µg/ mL, sebagai kontrol positif vitamin C memiliki nilai IC50 3,66 ± 0,02 µg/ mL. Kesimpulan penelitian ini adalah bahwa isolat kulit delima memiliki potensi antioksidan terkuat, dibandingkan ekstrak etanol 96% dan fraksi etil asetat kulit delima, bahkan juga vitamin C.
HUMAN HERPESVIRUS-6 MENINGOENCEPHALITIS AND PULMONARY TUBERCULOSIS IN HIV PATIENT: A CASE REPORT
Authors: Prabaningtyas Hanindia Riani , Putra Stefanus Erdana , Hafizhan Muhammad , Mirawati Diah Kurnia , Budianto Pepi
Published: April 2023

ABSTRACT

Human herpesvirus 6 (HHV-6), the causative agent of exanthema subitum in childhood, could also induce meningoencephalitis in immunocompromised individuals. We reported a case of 32-years-old woman with complaints of worsen headache, one week before admission. She also had intermittent fever and weakness in her left limb. She was admitted to a local hospital, suspected with tuberculous meningitis and pulmonary tuberculosis, and treated with anti-tuberculosis drugs, antibiotics for bacterial meningitis and steroids. She did not show any improvement, and then referred to X Surakarta General Hospital. On physical examination, we found GCS of E3V3M5, crackles and wheezing throughout the lung, neck stiffness, left hemiparesis, and clonus of the left lower leg. Laboratory results showed increasing leukocytes, reactive anti-HIV, and positive PCR for HHV-6 in the cerebrospinal fluid. On the CT scan, there were multiple hypodense lesions in the pons and right internal capsule, and communicant hydrocephalus. She was treated with highly active anti-retroviral therapy (HAART), Valganciclovir 900 mg b.i.d., steroid, anti-tuberculosis drugs and symptomatic treatment. After three weeks of admission, she began to show improvement, level of consciousness increased, and allowed went home.

ABSTRAK

Human herpesvirus-6 (HHV-6), agen penyebab eksantema subitum pada masa kanak-kanak, juga dapat menyebabkan meningoensefalitis pada individu dengan gangguan sistem imun. Kami melaporkan sebuah kasus, seorang wanita berusia 32 tahun dengan keluhan nyeri kepala yang semakin memberat sejak satu minggu sebelum masuk rumah sakit. Selain itu, pasien juga mengeluh demam intermiten dan kelemahan pada tungkai kiri. Pasien dirawat di rumah sakit lokal dengan diagnosis suspek meningitis tuberkulosis dan tuberkulosis paru dan ditatalaksana dengan obat anti tuberkulosis, antibiotik untuk meningitis bakteri dan steroid. Karena tidak ada perbaikan, pasien dirujuk ke RS X Surakarta. Pada pemeriksaan fisik ditemukan GCS E3V3M5, ronki dan mengi di seluruh lapang paru, kaku kuduk, hemiparesis kiri, dan klonus tungkai bawah kiri. Hasil laboratorium menunjukkan peningkatan leukosit, anti-HIV reaktif, dan PCR HHV-6 positif pada cairan serebrospinal. Pada CT-scan ditemukan lesi hipodens multipel pada pons dan capsula interna kanan serta hidrosefalus komunikan. Pasien ditatalaksana dengan highly active anti-retroviral therapy (HAART), Valgansiklovir 900mg/12 jam, steroid, obat anti tuberkulosis dan pengobatan simtomatik. Setelah perawatan selama tiga minggu, pasien mulai menunjukkan perbaikan, tingkat kesadaran meningkat, dan diperbolehkan pulang.
DOES FINANCIAL INCLUSION AFFECT PROFITABILITY OF COMMERCIAL BANKS?
Authors: Nguyen Thuy Duong , Nguyen Ngoc Tram , Nguyen Duc Huy , Huynh Anh Thu , Nguyen Thu Ha
Published: April 2023

Purpose: The objective of this study is to investigate the impact of financial inclusion on commercial banks profitability in 60 countries between 2017 and 2021.

Design/Methodology/Approach: The study used 300 observations from countries with developed and undeveloped banking systems. The paper applies estimation methods including Pooled OLS, FEM, REM and GLS related to panel data as well as multicollinearity, heteroscedasticity tests for model selection.

Research findings: Similar to previous papers, this research proved that most financial inclusion indicators have positive correlation with commercial banks profitability. In addition, this research suggested 3 new variables and pointed out: “Institutions of commercial banks”; “Outstanding-loans with commercial banks” positively impact banks profitability whereas “Outstanding-deposits with commercial banks” has negative influence on banks profitability.

Theoretical contribution/Originality: The majority of previous papers have explored the effect of financial inclusion at the national level, for example, the relationship between financial inclusion and economic growth. Meanwhile, this paper investigated the impact of financial inclusion on commercial bank profitability, an issue concerned recently.

Policy implication: This study can assist countries achieve a higher level of financial inclusion to raise commercial banks profitability, thereby boosting economic growth.
PEMANFAATAN LIMBAH MASKER SEKALI PAKAI SEBAGAI BAHAN PENGGANTI ASPAL TERHADAP NILAI STABILITAS DAN FLOW
Authors: Mutiara Permata Puspita Dewi  , Wike Andaresta Elsa Putri  , Pricillia Kurniawan  , Koes Paulina Cantik Bella
Published: April 2023

During the COVID-19 pandemic, it is essential to adhere to health protocols, one of which includes the use of a disposable mask for personal protection. However, the widespread use of single-use masks has resulted in a new problem, which is the accumulation of mask waste. Therefore, it is necessary to find a solution to reduce the amount of mask waste. One innovative solution to this problem is the utilization of masks in the infrastructure sector. Masks made of polypropylene are advantageous as they act as a good binder. By incorporating an appropriate percentage of mask waste, it is possible to produce bitumen with good parameters. This study aims to evaluate the stability and flow parameters of bitumen mixtures by substituting bitumen with 3-ply disposable mask waste. Experimental testing was conducted by replacing bitumen with mask waste at percentages of 0.5%, 0.75%, 1%, 1.5%, and 2%. The hot mix method was used to mix asphalt with the waste masks at a temperature of 150oC. Sensitivity analysis was performed to determine the impact of the percentage of mask waste on the stability and flow assessment parameters using the Marshall Test. The results of this study indicate that an increase in the percentage of mask waste leads to a sensitive response in the stability and flow values. The optimum percentage of mask waste for the mixture was found to be 1.50%, resulting in stability and flow values of 1020.36 kg and 4 mm, respectively.
Knowledge, Attitude, And Practice Among Healthcare Professionals Regarding the Myths On COVID-19 Vaccination: A cross-sectional questionnaire study and demystification
Authors: S Lokesh Kumar , Naik Zameera , Panwar Arun , M Sridhar , Keluskar Vaishali , K Ram Surath Kumar
Published: April 2023

Background: COVID-19 vaccine is the mighty weapon opted by all the countries across the globe in an attempt to eradicate the fatal COVID-19 pandemic. The myths on the COVID-19 vaccine are spreading widely, causing a hindrance to this noble preventive measure. The prevalence of such myths among healthcare professionals may be toxic and deadly.
Aim & Objectives: To assess the knowledge, attitude, and practice of the healthcare professionals regarding the myths on COVID-19 vaccination and to demystify them.Materials and Methods: An 18-item questionnaire evaluating knowledge, attitude, and practice based on the existing myths on COVID-19 vaccination was circulated through Google Forms® among the 412 healthcare professionals of six disciplines belonging to a private University. The responses obtained were subjected to statistical analysis using SPSS® 20 software package.
Results: A total of 385 health professionals participated in this study. The majority of them had medium knowledge (165) and positive attitude (273) with the mean knowledge and attitude scores of 3.82 ± 1.55 out of 6 and 4.3 ± 1.58 out of 7 respectively. Even though 312 participants got vaccinated, 72 of them failed to receive it. The knowledge scores showed a high statistically significant difference among the participants of different designations (p=0.001), but not with gender, field, and staff with different years of experience (p>0.05). The attitude scores were statistically different among participants of fields and designation (p<0.05) but not among genders (p=0.31) and staff with different years of experience (p=0.87). Knowledge and attitude scores showed a positive linear correlation and a high statistically significant difference (p<0.001).
Conclusion: This study recommends more enhanced education programs on COVID-19 vaccination for the health professionals and demands an improved knowledge, attitude, and practice among them to achieve the goal of 100% vaccination so as to completely eradicate the COVID-19 pandemic.
Islamic Law Review on Default and Unlawful Acts in Online Lending Practices
Authors: Fatihani Baso  , Kholifah Ayu
Published: April 2023

Debt in Islam is a social observance with the concept of helping (ta'awun). The presence of information technology-based lending is an innovation that aims to provide convenience for consumers to access needs in the form of loan funds. However, the presence of these online lending has taken many victims with many debtors receiving loans experiencing greater losses due to default disputes and unlawful acts in online lending practices. Indonesia as a country with the largest Muslim population needs to review this phenomenon from the point of view of Islamic law. The goal is that the society will not only become good citizens, but also become Muslims who are obedient to the provisions of Islamic law. This research is normative legal research which is also called doctrinal legal research. Descriptive analysis will be presented through literature study techniques from secondary data in the form of library materials. The results of the study show that online loans that have a great potential to cause default disputes and unlawful acts are a madharat that must be eliminated. The reason for making it easy to provide benefits to the community must be reviewed, because eliminating harm must take precedence over achieving benefit
Analysis of Customer Satisfaction from Service Quality Dimensions Using Fuzzy-Carter Method (A Case Study at Bprs Khasanah Ummat Purwokerto)
Authors: Selitri Melina  , Shafrani Yoiz Shofwa
Published: April 2023

The primary goal of a business is to satisfy customers, so the caliber of this service has a significant impact on the success of a service company, specifically the creation of a sense of satisfaction with the services provided, where this will foster a loyal attitude of its customers and encourage positive and encouraging word of mouth as an assumption of customer satisfaction. By assessing the value gap between the services obtained and the standard of service expectations by clients, this researcher investigates the quality of services offered by BPRS Khasanah Ummat. This kind of research comprises quantitative associative research using the Fuzzy-CARTER approach to examine the connection between the caliber of services rendered and client satisfaction. The sample of this research is 286 active customers. The study's findings indicate that: 1) the level of customer satisfaction is measured across six CARTER dimensions, five of which customers are satisfied, namely compliance, assurance, reliability, tangibles, and responsiveness, but customers are not satisfied with the service on the dimension of empathy, indicating that improvements must be made by paying more attention to and understanding customer needs. 2) The overall level of customer satisfaction with service quality is good, and there is no gap between perceived perceptions and customer expectations.
Comparative Analysis of Implementation of Murabahah Bil Wakalah Contracts and Musyarakah Mutanaqisah Contracts for Sharia Financing Products
Authors: Intansari Anggita Isty , Fatimah
Published: April 2023

A home is a basic human need that plays an important role in the continuation of human life. The problem of housing and settlement has existed and will continue to exist in response to population growth, demographics and socio-economic needs. The high demand for housing and population growth provide opportunities for Islamic financial institutions to provide products that help people purchase housing.

The purpose of this study is to determine the application of the Murabaha Contract and the Musharaka Mutanaqisah Contract and find a comparison of her two contracts in Islamic KPR funding. Knowing the mechanism and type of research represents field research. This research was conducted using qualitative methods with a descriptive approach.

As a result of the research and analysis, it was found that the application of the Murabaha Bil Wakala Convention takes precedence over the Musharaka Mutanaqishah Convention. A comparison of the two loan agreements can then be viewed in terms of similarities and differences between the two agreements.
Formulasi Sediaan Nanoemulgel Ekstrak Buah Lada Hitam (Piper ningrum L.) dengan Variasi Konsentrasi Tween 80 dan PEG 400
Authors: Andini Septia , Yulianita Yulianita , Febriani E Nurul Kholisoh
Published: April 2023

Buah lada hitam memiliki komponen utama yaitu senyawa piperin yang berkhasiat sebagai antiinflamasi. Pemakaian secara topikal dengan penghantaran obat melalui TDDS (Transdermal drug delivery system) diharapkan dapat meningkatkan penetrasi obat sehingga lebih efektif. Nanoemulgel merupakan sediaan nanoemulsi dengan ukuran droplet kisaran 50-1000 nm dengan penambahan basis gel. Nanoemulgel dipilih karena sistem penghantaran obat berpenetrsi kedalam kulit sehingga dapat meningkatkan bioavailabilitas suatu zat aktif. Penelitian ini bertujuan untuk membuat sediaan Nanoemulgel dengan variasi konsentrasi surfaktan Tween 80 dan kosurfaktan PEG 400. Sebanyak tiga formula dibuat dengan variasi konsentrasi surfaktan Tween 80 dan kosurfaktan PEG 400 yaitu F1 (30:30); F2 (35:25); dan F3 (40:20). Ekstraksi buah lada hitam dengan metode sokletasi dengan pelarut etanol 96%. Tahap pembuatan sediaan Nanoemulgel dibuat dalam 3 tahap yaitu pembuatan nanoemulsi, pembuatan basis gel dan pencampuran nanoemulsi ke dalam basis gel. Hasil penelitian menunjukkan Formula 3 merupakan formula terbaik dan stabil dilihat dari  hasil pengujian ukuran partikel (59,37) nm, polidispersitas indeks (0,25), zeta potensial (-28,9) mV, dan pH sediaan (5,60±0,01).
Pengaruh Pelayanan Informasi Swamedikasi Online Berbasis Whatsapp Bot terhadap Pengetahuan Masyarakat
Authors: Widyaningrum Esti Ambar , Fadrian Moza Fellya , Admaja Wika
Published: April 2023

Latar belakang: Revolusi industri 4.0 pada era digital saat ini mendorong untuk berkembangnya Teknologi, Informasi dan Komunikasi (TIK) dimana salah satu bidang yang terus berkembang dan mengadopsi TIK adalah e-health. Di bidang kefarmasian, e-health dikembangkan lagi menjadi e-pharmacy yang digunakan sebagai sarana pelayanan informasi obat (PIO) yang diharapkan dapat memudahkan masyarakat dalam mengakses informasi terkait obat. Inovasi pelayanan informasi swamedikasi online sangat diperlukan untuk memudahkan pencarian informasi sehingga diharapkan pengetahuan masyarakat dapat meningkat dalam melakukan swamedikasi yang rasional. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh layanan swamedikasi online berbasis WhatsApp Bot terhadap tingkat pengetahuan masyarakat. Metode: Metode yang digunakan dalam penelitian ini adalah quasi-experiment: one-group pretest-posttest design yang dilanjutkan dengan metode survei analitik dengan desain cross sectional. Pengambilan sampel dilakukan dengan purposive sampling dan didapatkan 113 responden yang berasal dari warga Kelurahan Talun, Kabupaten Blitar. Hasil: Profil karakteristik responden: jenis kelamin terbanyak perempuan (71,7%), rentang usia 17-25 tahun (60,2%), pendidikan akhir SMA (62,8%), pekerjaan pelajar/mahasiswa (38,1%), dan penghasilan 0 (44,2%). Menu layanan swamedikasi online berbasis WhatsApp Bot terbanyak diakses: definisi swamedikasi (18,7%) dan penyakit khususnya acne vulgaris (17,7%). Tingkat pengetahuan responden sebelum mendapatkan intervensi layanan informasi swamedikasi online kategori baik 67,3%, cukup baik 26,5%, kurang baik 4,4%, dan tidak baik 1,8% dan meningkat menjadi 100% kategori baik setelah intervensi. Pengaruh pelayanan informasi swamedikasi online berbasis WhatsApp Bot terhadap tingkat pengetahuan responden diuji dengan Wilcoxon Signed Rank Test dengan p-value ≤ 0.05. Kesimpulan: Terdapat pengaruh pelayanan informasi online berbasis WhatsApp Bot terhadap tingkat pengetahuan swamedikasi masyarakat.
Review : Evaluasi Stabilitas dan Inkompatibilitas Sediaan Oral Liquid
Authors: Qomara Windi Fresha , Musfiroh Ida , - Rina Wijayanti
Published: April 2023

Stabilitas suatu sediaan sangat penting dalam menentukan kualitas, efikasi dan keamanan suatu produk karena produk yang stabil dapat menentukan keberhasilan pengobatan. Banyak faktor yang mempengaruhi suatu produk menjadi tidak stabil. Salah satu bentuk sediaan farmasi yang paling disukai adalah sediaan cairan oral karena kemudahan dalam mengkonsumsinya. Untuk menentukan stabilitas dan kompatibilitas sediaan oral liquid dilakukan pencarian literature pada situs Google Scholar dan PUBMED menggunakan kata kunci dengan total jurnal yang didapatkan adalah 266 jurnal dan setelah diskrining terdapat 21 jurnal yang masuk kriteria inklusi dan totalnya digunakan 53 referensi dalam review ini. Dari hasil pencarian literatur tersebut didapatkan bahwa banyak faktor yang dapat mempengaruhi kestabilan sediaan cair oral seperti suhu, pH dan juga mikroba. Untuk itu dalam proses formulasi perlu dikaji keadaan yang paling cocok dengan karakteristik bahan yang digunakan baik zat aktif, eksipien maupun bahan kemas. Untuk menentukan kestabilan sediaan farmasi dilakukan dengan uji stabilitas dengan mengatur suhu dan kelembaban sesuai dengan zona klimatik serta pengujian dilakukan pada rentang waktu tertentu. Setelah melakukan uji stabilitas perlu dilakukan evaluasi sediaan seperti pemampilan baik dari warna, bau rasa, kemudian dari viskositas, pH, kejernihan, endapan dan juga pemisahan fase, serta kadar sediaan.
Hallazgos de cerámica romana vidriada en la Bética
Authors: Serrano Ramos Encarnación
Published: April 2023

No disponible
Castillos y lugares de alfoz de Antequera en la Baja Edad Media
Authors: Alijo Hidalgo Francisco
Published: April 2023

No disponible
El puerto de Málaga en la transición a los tiempos modernos. Introducción a su estudio
Authors: López Beltrán Mª Teresa
Published: April 2023

No disponible
Contribución de Aristóteles a la historiografía filosófica
Authors: Martínez Lorca Andrés
Published: April 2023

No disponible
Una Inmaculada de la escuela de Alonso de Mena
Authors: Aguilar Mª Dolores
Published: April 2023

No disponible
El monumento al Marqués de Larios en Málaga y la problemática de la escultura decimonónica
Authors: Sánchez-Mesa Martín Domingo
Published: April 2023

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Explotación de nieves en Yunquera
Authors: Pérez de Colosía Rodríguez Mª Isabel
Published: April 2023

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En los orígenes del periodismo malagueño: la Gazeta Nueva de 1677
Authors: García Galindo Juan Antonio
Published: April 2023

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Historia política de la Década Ominosa. 1823-1833 en Málaga. Absolutismo y liberalismo
Authors: Nadal Sánchez Antonio
Published: April 2023

No disponible
Hallazgo de un togado en Teba (Málaga)
Authors: Fernández Ruiz Juan
Published: April 2023

No disponible
Socialización y personalización en Teilhard de Chardin
Authors: Martínez Lorca Andrés
Published: April 2023

No disponible
Consideraciones generales sobre el megalitismo en Andalucía
Authors: Ferrer Palma José Enrique
Published: April 2023

No disponible
El conjunto de hermae-retratos de Obulco
Authors: Rodríguez Oliva Pedro
Published: April 2023

No disponible
Sobre una escultura femenina aparecida en Santaella (Córdoba)
Authors: Serrano Ramos Encarnación , Baena del Alcazar Luis
Published: April 2023

No disponible
Sobre el origen del topónimo pliniano Litus Curense
Authors: Chenoll Alfaro Rafael R.
Published: April 2023

No disponible
Comunicación social e historia. En torno a la historia de la prensa: el caso de Málaga en el siglo XX
Authors: García Galindo Juan Antonio
Published: April 2023

No disponible
El desafío del conflicto de las Malvinas
Authors: Giménez Vega Elías S.
Published: April 2023

No disponible