bluuebunny/crossref_metadata_2025 huggingface dataset:
Le monologue d’entrée de rôle dans les tragédies de Sénèque : de l’animation du personnage à la rencontre
Authors: Pierre Maxime
Published: April 2024

Entrance monologues are one of the most striking features of the characters in Seneca’s tragedy that we don’t find in his Attic models. Often seen as a psychological parenthesis, this specificity is supposed to create a break in the dramatic action. However, if we go back to the text of those scenes, we can understand them as a theatrical device : they allow the entering character to give life to his mask and prepare his meeting with other characters. Entrance monologues are linked with physical descriptions and create a dramatic tension at every new entrance of a character in the play.
Raconter le passé le plus lointain de Rome - le vocabulaire de la mémoire historique chez Tite-Live (I-II, 14)
Authors: Martin Paul
Published: April 2024

This paper aims at evaluating up to which point Livy estimates trustworthy his own narrative starting from the regal period and ending with the Roman revolution. Six words have been selected so as to serve as filters whereby the narrator distanciates himself from his narrative, either proving himself most doubtful or, on the contrary, quite certain of the facts. By evaluating how often these words occur in the text, it has been made possible to understand the criteria on which Livy relied to trust or not the various elements on which the traditional account of the most ancient History of Rome were based.
Les monumenta dans l’Énéide de Virgile : entre souvenirs, commémoration et monument littéraire
Authors: Raymond-Dufouleur Emmanuelle
Published: April 2024

This contribution proposes an examination of the different occurrences of the word monumentum in Virgil’s Aeneid, which aims to highlight the Virgilian epic as a “ monumental” work. The study thus makes it possible to define the Virgilian carmen

at the same time as a place where concrete and abstract manifestations of remembrance are revealed, a poetic of commemoration and contruction of a collective memory, and a literary work that engages the memory of posterity.
Polypharmacy in Patients with CKD
Authors: Oosting Ilse J. , Colombijn Julia M.T. , Kaasenbrood Lotte , Liabeuf Sophie , Laville Solène M. , Hooft Lotty , Bots Michiel L. , Verhaar Marianne C. , Vernooij Robin W.M.
Published: April 2024

Key Points

The prevalence of polypharmacy in patients with CKD was over 80%.

Polypharmacy was highest in patients with a kidney transplant and those receiving dialysis.

Polypharmacy is associated with worse clinical outcomes, lower quality of life, and medication-related problems in patients with CKD.

Background

Despite the high prevalence of polypharmacy in patients with CKD, the extent of polypharmacy across patients with (different stages of) CKD, as well as the association with clinical outcomes remains unknown. This systematic review aimed to evaluate the prevalence of polypharmacy in (different subgroups of) patients with CKD and assess the association between polypharmacy and patient-important outcomes.

Methods

MEDLINE, Embase, and the Cochrane Library were searched from inception until July 2022. Studies that reported the prevalence of polypharmacy, medication use, or pill burden in patients with CKD (including patients receiving dialysis and kidney transplant recipients) and their association with patient-important outcomes (i.e., mortality, kidney failure, quality of life [QoL], and medication nonadherence) were included. Two reviewers independently screened title and abstract and full texts, extracted data, and assessed risk of bias. Data were pooled in a random-effects single-arm meta-analysis.

Results

In total, 127 studies were included (CKD 3–5 n=39, dialysis: n=38, kidney transplant n=13, different CKD stages n=37). The pooled prevalence of polypharmacy, based on 63 studies with 484,915 patients, across all patients with CKD was 82% (95% confidence interval, 76% to 86%), and the pooled mean number of prescribed medications was 9.7 (95% confidence interval, 8.4 to 11.0). The prevalence of polypharmacy was higher in patients who received dialysis or a kidney transplant compared with patients with CKD 3–5 but did not differ between studies with regards to region or patients' mean age or sex. In patients with CKD, polypharmacy was associated with a higher risk of all-cause mortality, kidney failure, faster eGFR decline, lower QoL, and higher medication nonadherence, adverse drug reactions, and potentially inappropriate medications.

Conclusions

The prevalence of polypharmacy in patients with CKD was over 80%, and highest in patients with a kidney transplant and those receiving dialysis. No causes of heterogeneity were identified, indicating that polypharmacy is an issue for all patients with CKD. Polypharmacy is associated with worse clinical outcomes, lower QoL, and medication-related problems in patients with CKD.

Clinical Trial registry name and registration number:

PROSPERO (CRD42022331941).
Determining the JAK2 V617F mutation at Hue University of Medicine and Pharmacy Hospital
Authors: Nguyen Thi Mai Ngan , Doan Thi Duyen Anh , Le Phan Tuong Quynh , Ngo Thi Dieu Huong , Nguyen Quynh Chau , Vo Tu Hieu , Dang Tran Huu Hieu , Ton That Minh Tri , Ha Thi Minh Thi
Published: April 2024

Background: JAK2 V617F mutation is one of the major criteria in diagnosing MPNs. This study aimed to: (1) Establish a procedure and compare Allele specific-PCR and PCR-RFLP techniques in identifying JAK2 V617F mutation; (2) Primarily evaluate the prevalence of V617F mutation of JAK2 gene in patients with MPNs.

Materials and methods: DNA extraction was isolated from peripheral blood of 31 patients with MPNs followed by clinicians and 10 healthy individuals. Determining V617F mutation of JAK2 gene by AS-PCR and PCR-RFLP techniques. Sanger sequencing randomly 15% of samples for comparison. Results: The optimal annealing temperature for AS-PCR is 55oC. Conditions of restriction digest in PCR-RFLP uses 300 ng of PCR product. All samples identified by AS-PCR and PCR-RFLP showed similar results.

Conclusion: Established a procedure to identify the V617F mutation in JAK2 gene by allele-specific PCR and PCR-RFLP, in which the AS-PCR technique showed more advantages. The frequency of V617F mutation of JAK2 gene in patients was 61.3%.

Key words: MPNs, V617F, JAK2, allele-specific PCR, PCR-RFLP
Dissecting Spatiotemporal Structures in Spatial Transcriptomics via Diffusion-Based Adversarial Learning
Authors: Wang Haiyun , Zhao Jianping , Nie Qing , Zheng Chunhou , Sun Xiaoqiang
Published: April 2024

Recent advancements in spatial transcriptomics (ST) technologies offer unprecedented opportunities to unveil the spatial heterogeneity of gene expression and cell states within tissues. Despite these capabilities of the ST data, accurately dissecting spatiotemporal structures (e.g., spatial domains, temporal trajectories, and functional interactions) remains challenging. Here, we introduce a computational framework, PearlST (
p
artial differential equation [PDE]-
e
nhanced
a
dversa
r
ia
l
graph autoencoder of
ST
), for accurate inference of spatiotemporal structures from the ST data using PDE-enhanced adversarial graph autoencoder. PearlST employs contrastive learning to extract histological image features, integrates a PDE-based diffusion model to enhance characterization of spatial features at domain boundaries, and learns the latent low-dimensional embeddings via Wasserstein adversarial regularized graph autoencoders. Comparative analyses across multiple ST datasets with varying resolutions demonstrate that PearlST outperforms existing methods in spatial clustering, trajectory inference, and pseudotime analysis. Furthermore, PearlST elucidates functional regulations of the latent features by linking intercellular ligand–receptor interactions to most contributing genes of the low-dimensional embeddings, as illustrated in a human breast cancer dataset. Overall, PearlST proves to be a powerful tool for extracting interpretable latent features and dissecting intricate spatiotemporal structures in ST data across various biological contexts.
Harnessing AI for Education 4.0: Drivers of Personalized Learning
Authors: Barrera Castro Gina Paola , Chiappe Andrés , Becerra Rodriguez Diego Fernando , Sepulveda Felipe Gonzalo
Published: April 2024

Personalized learning, a pedagogical approach tailored to individual needs and capacities, has garnered considerable attention in the era of artificial intelligence (AI) and the fourth industrial revolution. This systematic literature review aims to identify key drivers of personalized learning and critically assess the role of AI in reinforcing these drivers. Following PRISMA guidelines, a thorough search was conducted across major peer-reviewed journal databases, resulting in the inclusion of 102 relevant studies published between 2013 and 2022. A combination of qualitative and quantitative analyses, employing categorization and frequency analysis techniques, was performed to discern patterns and insights from the literature. The findings of this review highlight several critical drivers that contribute to the effectiveness of personalized learning, both from a broad view of education and in the specific context of e-learning. Firstly, recognizing and accounting for individual student characteristics is foundational to tailoring educational experiences. Secondly, personalizing content delivery and instructional methods ensures that learning materials resonate with learners' preferences and aptitudes. Thirdly, customizing assessment and feedback mechanisms enables educators to provide timely and relevant guidance to learners. Additionally, tailoring user interfaces and learning environments fosters engagement and accessibility, catering to diverse learning styles and needs. Moreover, the integration of AI presents significant opportunities to enhance personalized learning. AI-driven solutions offer capabilities such as automated learner profiling, adaptive content recommendation, real-time assessment, and the development of intelligent user interfaces, thereby augmenting the personalization of learning experiences. However, the successful adoption of AI in personalized learning requires addressing various challenges, including the need to develop educators' competencies, refine theoretical frameworks, and navigate ethical considerations surrounding data privacy and bias. By providing a comprehensive understanding of the drivers and implications of AI-driven personalized learning, this review offers valuable insights for educators, researchers, and policymakers in the Education 4.0 era. Leveraging the transformative potential of AI while upholding robust pedagogical principles, personalized learning holds the promise of unlocking tailored educational experiences that maximize individual potential and relevance in the digital economy.
MENTORING AS A TREND OF UPDATING THE SYSTEM OF NON-FORMAL EDUCATION OF TEACHING STAFF
Authors:   National University of Oil and Gas «Gubkin University», FILATOVA M.N. , VOLKOVA L.V. ,   National University of Oil and Gas «Gubkin University»
Published: April 2024

The article is devoted to the problem of the development of non-formal education, which is especially relevant in the modern system of continuing professional education. The traditional model of discrete professional development of teaching staff does not fully meet the challenges of modern education, because it does not always respond quickly to the requests of the pedagogical community. The changes taking place in society require the search for new approaches in the system of professional development of teaching staff. This task is helped by non-formal education aimed at developing the competencies of teaching staff who carry out their professional development for a specific task. Non-formal education allows you to give answers to questions that arise before the pedagogical community in the "here and now" format. One of the models of non-formal education, the core of which are various mentoring methods, is considered. The institute of mentoring is gaining popularity, and the mentor will enter the list of professions in the near future. The main advantage of mentoring as a modern form of competence development is the ability not to completely break away from the main work of either the student or the trainee. The process of institutionalization of mentoring is at an initial stage today. The issues of organizational forms, legal regulation, criteria for personnel selection and training of mentors, their material and non-material incentives need to be addressed.
ATTRACTIVENESS OF THE DESTINATION: DEMOGRAPHIC ASPECT
Authors:   Volgograd State Technical University, MELNIKOVA E.V. , FADEEVA E.A. ,   Volgograd State Technical University, MINEEV M.A. ,   Volgograd State Technical University
Published: April 2024

The article examines the destination in the context of regional development. The factors that determine the attractiveness of a destination for tourists are given. It is noted that the assessment parameters determine target quantitative and qualitative indicators that indicate the satisfaction of tourists’ requests, but at the same time, tourist expectations associated with the accessibility and infrastructure of the destination will be heterogeneous among potential tourists, as well as the perception of price levels, safety and comfort of stay. The authors demonstrate with examples that travel goals and tourist interest in the same destination can differ for representatives with different demographic characteristics. The difference in interests and tourist goals must be taken into account when discussing and forming a regional development strategy, which should take into account the formed image of the territory and the brand, while the image can not only change over time, but also have its own specifics for different target groups. For the Volgograd destination, educational and tourist attraction is designated as in demand among foreign students. By developing a network of necessary institutions, organizations, accommodation facilities, services and entertainment infrastructure, it is possible to increase the interest, first of all, of the youth audience not only in traveling, but also in permanent residence in the Volgograd region.
PROBLEMS OF ADAPTATION OF FOREIGN STUDENTS IN RUSSIAN UNIVERSITIES (BY THE EXAMPLE OF VOLGOGRAD STATE TECHNICAL UNIVERSITY)
Authors:   Volgograd State Technical University, BORODINA E.A. , VELIKANOV V.V. ,   Volgograd State Technical University
Published: April 2024

Teaching foreign students is an important and complex task that requires a serious approach and constant work to improve the quality of adaptation of foreign students, optimize learning processes and improve the quality of the education received. The materials presented in the article are a generalized experience of the work of curators of groups of foreign students at Volgograd State Technical University.
Decentralised finance, regulation, and systems theory
Authors: Paterson John
Published: April 2024

Cryptocurrency has sparked expressions of concern from regulators – though sometimes coupled with expressions of interest in state-backed alternatives. This paradoxical situation neatly encapsulates the conundrum confronting regulators as they seek to come to terms with the new world opened up by blockchain and leading ultimately perhaps to decentralised finance. How do we best understand this confusing situation? This paper looks for answers by attempting to conceptualise the phenomenon of decentralised finance in autopoietic systems terms. Insofar as a plausible argument can be made for the proposition that finance represents an example of the internal differentiation of the economy, does decentralised finance in some sense constitute an intensified internal differentiation? Alternatively, and paradoxically, insofar as what we are concerned with is decentralised finance, does it instead in some sense represent an example of dedifferentiation? Answers to these questions will have relevance for efforts to regulate this emerging phenomenon. They will also help to shed light on whether state and central bank experiments in this space will produce positive effects or bring their own challenges.
La criptomoneda ha suscitado la preocupación de los reguladores, aunque a veces ha ido acompañada del interés expresado sobre algunas alternativas respaldadas por el Estado. Esta paradójica situación resume a la perfección el enigma al que se enfrentan los reguladores cuando tratan de aceptar el nuevo mundo abierto por la cadena de bloques y que, en última instancia, quizá conduzca a unas finanzas descentralizadas. ¿Cuál es la mejor manera de entender esta confusa situación? Este artículo busca respuestas intentando conceptualizar el fenómeno de las finanzas descentralizadas en términos de sistemas autopoiéticos. En la medida en que se puede argumentar de forma plausible que las finanzas representan un ejemplo de la diferenciación interna de la economía, ¿constituyen las finanzas descentralizadas, en cierto sentido, una diferenciación interna intensificada? Por otra parte, y paradójicamente, en la medida en que tratamos sobre finanzas descentralizadas, ¿representan en cierto sentido un ejemplo de desdiferenciación? Las respuestas a estas preguntas serán relevantes para los esfuerzos por regular este fenómeno emergente. También ayudarán a arrojar luz sobre si los experimentos del Estado y los bancos centrales en este espacio producirán efectos positivos o nuevos desafíos.
Do you practice what (E)U preach? The EU system of cross-border protection for victims of recurrent crimes
Authors: Amato Rosanna
Published: April 2024

Victims of recurrent crimes, particularly Intimate Partner Violence (IPV) victims, encounter unique challenges with the criminal justice system. The risk of repeat violence and retaliation deters them from engaging with legal processes, emphasising the critical need for effective protection measures in domestic and cross-border contexts. Protection orders, pivotal in preventing further victimisation, primarily operate within the issuing State, which has prompted the European Union to establish legal instruments based on the principle of mutual recognition to extend their applicability beyond national borders. Despite this, these measures are strikingly underused. This article delves into the root causes of this underutilisation and questions the overall usability of these measures by its beneficiaries. It also explores potential legal and non-legal solutions to transform them into a tangible resource for victims of recurring crimes across the EU.
Las víctimas de delitos recurrentes, en particular las víctimas de violencia de pareja, se enfrentan a retos únicos con el sistema de justicia penal. El riesgo de repetición de la violencia y de represalias las disuade de participar en procesos judiciales, lo que pone de relieve la necesidad crítica de medidas de protección eficaces en contextos nacionales y transfronterizos. Las órdenes de protección, fundamentales para evitar nuevas victimizaciones, funcionan principalmente dentro del Estado de emisión, lo que ha llevado a la Unión Europea a establecer instrumentos jurídicos basados en el principio de reconocimiento mutuo para ampliar su aplicabilidad más allá de las fronteras nacionales. A pesar de ello, estas medidas están sorprendentemente infrautilizadas. Este artículo ahonda en las causas profundas de esta infrautilización y cuestiona la utilidad general de estas medidas por parte de sus beneficiarios. También explora posibles soluciones jurídicas y no jurídicas para transformarlas en un recurso tangible para las víctimas de delitos recurrentes en toda la UE.
As origens e evolução da indústria têxtil no Brasil: uma perspectiva global e de longo prazo
Authors: Deliberali Marson Michel
Published: April 2024

A indústria têxtil foi de extrema importância para o processo de industrialização no mundo. Esse ramo industrial foi o primeiro a se mecanizar em regiões da Europa, promovendo um impulso de ganhos de produtividade que alterou a perspectiva de produção e consumo antes conhecida, e para alguns, possibilitou a ruptura necessária para o desenvolvimento econômico. A indústria têxtil no Brasil, devido a sua importância para o processo de industrialização, foi relativamente bem estudada. No entanto, faltam trabalhos que a coloquem em perspectiva global, comparando com o desenvolvimento de outras regiões do mundo. O objetivo do artigo é promover uma análise da indústria têxtil no Brasil em perspectiva comparativa mundial, desde o início do processo de industrialização em regiões da Europa até meados do século XX, quando a indústria têxtil no Brasil atingiu o seu apogeu em importância para o processo de industrialização.
Salcedo, J. (2022) Los Montoneros del Centro. Tácticas y estrategias de la conducción montonera, 1966-1976. Buenos Aires: Prometeo, 396 páginas.
Authors: Boetto María Belén
Published: April 2024

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Fernández Sebastián, J. (2021). Historia conceptual en el Atlántico ibérico. Lenguajes, tiempos, revoluciones. México: Fondo de Cultura Económica, 2021, 571 páginas.
Authors: Rivera Víctor Samuel
Published: April 2024

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Difficulty of Energy Expenditure of Brain When Using Written Speech
Authors: Saveliev Sergei , Chuev Alexander
Published: April 2024

The structural organization of the brain matures between 16 and 22 years old when spontaneous contradictions in individual behavior appear with the greatest frequency which is caused by the duality of human consciousness based on the early maturing instinctive-hormonal centers of the limbic system and the late differentiating neocortical fields of voluntary thinking. When creating a written speech, limbic and cortical mechanisms of motivational control are used and individualize the resulting text. Personalization of writing meaningful texts is enhanced by the variability of brain structures involved in this process. We examined evolutionary morphofunctional systems to evaluate their biological value. Depending on individual priorities and motivational choices, written composition was carried out in two strategies. The first was the most general principle of saving the energy expenditure of the brain during any voluntary activity. The second was the mobilization of cortical centers with extremely high energy costs. To identify these differences, a pragmalinguistic analysis technique was developed in this study, supporting both strategies.
ANALISIS KELAYAKAN FINANSIAL USAHA TERNAK BABI (Studi Kasus : Peternak Babi Desa Kalasey Satu Kecamatan Mandolang Kabupaten Minahasa)
Authors: Winokan Anita Meilina , Tilaar Wenny , Kalangi Jolanda Kitsia Juliana
Published: April 2024

This study aims to determine the level of profit and analyze the financial feasibility of pig farming. The research was conducted using a case study method on pig farmers in Kalasey Satu Village, Mandolang District, Minahasa Regency from May 2021 to July 2021. The selection of respondents was carried out by purposive sampling. The data used are primary data and secondary data. Primary data were obtained from respondents through direct interviews with one pig farmer respondent. Secondary data were obtained from various sources, namely the Village Office, the Central Statistics Agency (BPS) and the Minahasa Regency Agriculture Office. The results showed that with an investment of Rp 62.035.000,00, and the production cost is Rp 1.028.555.563,00 the proceeds from the sale of pigs amounted to Rp 1,227,440,000,00 and a profit of Rp 136,849,437,00. The results of the analysis show the value of Net Present Value (NPV) = 36.010.033, Net Benefit Cost Ratio (Net B//C) = 1.51, Internal Rate of Return (IRR) = 29.79%, Payback Period (PP) = 1.48. Based on the results of the financial feasibility analysis, the pig farming business in Kalasey Satu Village earns a profitable income and is feasible to continue.
ANALISIS RANTAI PASOK PADA KOMODITAS KOPRA DI DESA LOWIAN KECAMATAN MAESAAN KABUPATEN MINAHASA SELATAN
Authors: Taula Vinni S. , Pakasi Caroline Betsi Diana , Baroleh Jenny
Published: April 2024

The study aims to identify supply chains based on product flow, information flow, financial flow and analyze the level of marketing efficiency in the copra commodity supply chain. This research was carried out for three months, from August to October 2021, which took place in Lowian Village, Maesaan District, South Minahasa Regency. This study uses primary data and secondary data. The population in this study were all coconut farmers and copra collectors. Sampling using a simple random sampling method (simple random sampling) obtained 50 farmers from a population of 248 farmers and 3 traders collectors. The results showed that the supply chain in Lowian Village was based on product flow from upstream to downstream starting from copra farmers, collectors, and copra processing factories. The flow of information flows from two directions, namely the first direction the factory provides information to traders about the quality and price of copra needed then traders provide price information to farmers, the second direction is farmers provide information to traders about the quality of copra sold then traders will inform the factory about the volume marketing of copra to be sold. As for the financial flows from downstream to upstream, starting from factories that buy copra from collecting traders via bank transfer, then collecting traders buy copra from farmers with a cash payment system. The level of marketing efficiency in the copra supply chain seen from the total marketing margin, marketing costs and profits has been efficient.
TINGKAT KEPUASAN KONSUMEN TERHADAP PELAYANAN DI RUMAH KOPI BILLY JALAN 17 AGUSTUS KOTA MANADO
Authors: Ramli Irfandi , Ngangi Charles Reijnaldo , Maweikere Audrey Julia Maria
Published: April 2024

This study aims to determine the level of consumer satisfaction with services at Rumah Kopi Billy Jalan 17 Agustus Manado City. The research lasted for 2 months and was carried out from September to October 2021. The data collected, namely primary data, was obtained from direct interviews with consumers as visitors by using a questionnaire. Secondary data were obtained from coffee house owners as well as data related to research taken from the internet. Sampling was doneby accidental sampling as many as 5 respondents every day from Monday to Saturday which could be found so that the number of respondents was 30 people. The results showed that the level of consumer satisfaction with services at the Rumah Kopi Billy Jln 17 Agustus, Manado was included in the satisfied category with a satisfaction index of 77.68% based on product, price, place, promotion and service quality.
Comprehensive investigation of the explicit, positivity preserving methods for the heat equation
Authors: Khayrullaev Husniddin , Kovács Endre
Published: April 2024

In this paper-series, we investigate the performance of 12 explicit non-conventional algorithms. All of them have the convex combination property, thus they are unconditionally stable and preserve the positivity of the solution when they applied to the heat equation. In this part of the series, we construct several 2D systems to find how the errors depend on the time step size. Sweeps for other key parameters will be presented in the next part of the series.
Explained – How Layoffs Affect Employees in Startup Ecosystem
Authors:   Research Scholar, Department of Management, Manav Rachna International Institute of Research and Studies, Faridabad (Haryana), India., Vishwapriya  , Mohsin Dr. Farhat ,   Associate Professor, Department of Management,  FMS, Manav Rachna International Institute of Research and Studies, Faridabad (Haryana), India.
Published: April 2024

Experiencing a layoff can be a challenging and overwhelming time of loss and adjustment. While some individuals may view it as an opportunity for a fresh start or a welcome relief from a demanding work environment, for others, the loss of their career can be deeply distressing. Coping mechanisms for stress and change vary among individuals, but the following paper outlines common emotional, psychological, and physical reactions. In the past, layoffs were primarily seen as a last-resort measure during times of economic recession or crisis. However, they have become more commonplace in today's business landscape, particularly in the commercial sector. Many companies have recently announced layoffs, citing the need to increase profitability as the economy recovers and job prospects improve. Unfortunately, these layoffs often do not result in the intended profitability. The dynamics are quite different within the startup ecosystem. This research paper will delve into the journey of layoffs in startups and explore their impact on employees. Layoffs can be highly stressful for both startups and their employees. The paper will examine the aftermath of layoffs on employees and provide recommendations to help them navigate this challenging situation.
Braille Script Translator Website
Authors: P Akshay Krishna , M Madhanraj , Nair Midhun S , N Mohamed Niyaz , Visakh Divya
Published: April 2024

As technology rapidly evolves, ensuring inclusivity for all members of society, including visually impaired individuals, becomes imperative. This paper introduces Braille Script Translator, a versatile tool designed to address the communication gap between visually impaired individuals and teachers or parents working with them. The system offers a multimodal approach, allowing users to input Braille text via uploaded images, voice, or text. Through the integration of a comprehensive Braille database, the system translates Braille text to English and vice versa, ensuring reliable results. The output is presented through a user-friendly interface, prioritizing ease of use for all users. Performance evaluation focuses on accuracy and efficiency, while user experience testing provides valuable insights for further refinement. Braille Script Translator represents a significant step forward in enhancing accessibility and inclusivity in digital communication.
Underwater Image Restoration and Object Detection
Authors: R Rohan , R Vishnu Prakash , K T Shibin , K Akshay , E Akhila
Published: April 2024

Underwater environments present unique challenges for imaging due to factors such as light attenuation, scattering, and colour distortion. This research combines advanced CNN models like CBAM(convolutional Block Attention Mod-ule) and VGG16 with state-of-the-art object detection methods of CNN like YOLO or RCNN to enhance the visual quality of underwater images and to detect the objects based on an accuracy rate. Leveraging the various capabilities of the VGG16 model, pretrained on extensive datasets, the system efficiently restores degraded underwater images by capturing and learning intricate features. Integrating the CBAM model enhances this process by selectively attending to salient features while suppressing irrelevant ones, thereby refining the restoration results. Additionally, the combined architecture facilitates object detection within the restored images, enabling the identification and localization of submerged objects with high accuracy. Currently the work presents short review on the existing methods of underwater image restoration and a suggests method employing the CBAM(convolutional Block Attention Mod-ule) and VGG16 to overcome the prevailing challenges in underwater object detection. In future, the research aims to present a website that would be more useful for the students , researchers and the underwater explorers.
JCET Companion: Mobile Application for Campus Assistance
Authors: A Ajith , A R Aswin , V Atul , P K Kishor , Visakh Divya
Published: April 2024

JCET (Jawaharlal College of Engineering and Technology) Companion, the innovative mobile app thoughtfully designed for JCET college community, introduces a comprehensive suite of indispensable features aimed at simplifying and enhancing campus life. At its core, the app provides a user-friendly event calendar intricately linked with a reminder system, ensuring students never miss vital dates or essential college events. The meticulously organized study material empowers efficient learning, while crucial announcements keep users informed. With seamless attendance tracking and notifications, students stay accountable and punctual. Homework management, to-do lists, fee handling through an integrated gateway, and efficient leave request management all find a home in this app, uncluttering the daily tasks that typically burden students. In essence, JCET Companion offers a centralized platform, fostering a sense of community and shared experience while ensuring everyone is consistently up to date, transforming college life into a well-organized and informed journey, marked by enhanced efficiency and connectivity for all its users.
Hypercalcemia – an underestimated medical problem
Authors: Rozenek Emil , Misiorowski Waldemar
Published: April 2024

Hypercalcemia affects approximately 1% of the worldwide population. This electrolyte abnormality is frequent both in out and inpatients (varies from 0,17 to 5% in hospitalized, however incidence increases even up to 7,5% in emergency departments in some populations). Primary hyperparathyroidism (PHPT) and hypercalcemia of malignancy (HCM), account for more than 90 percent of all causes of hypercalcemia. Other causes of hypercalcemia, such as vitamin D intoxication, granulomatous disorders, milk-alkali syndrome, medications, familial hypocalciuric hypercalcemia and immobilization amount to less than 10% of all causes of hypercalcemia. However, once primary hyperparathyroidism or cancer has been excluded, other causes of hypercalcemia, often life-threatening and requiring appropriate causal management, should be considered. Considering rare etiologies is important, nevertheless, when primary hyperparathyroidism or malignancy do not account for the hypercalcemia. The review describes patophysiology, symptoms and diagnostic approach to the most relevant causes of hypercalcemia.
A Influência da Educação no conhecimento sobre Microbiota Intestinal e sua Repercussão na Saúde Humana Revisão Narrativa da Literatura
Authors: De Souza e Silva Maria Eduarda , De Paula Menezes Ralciane , Röder Denise Von Dolinger de Brito
Published: April 2024

A microbiota intestinal, composta por uma diversidade de microrganismos que residem no trato gastrointestinal humano, desempenha um papel vital na manutenção da saúde do hospedeiro. Estes microrganismos desempenham funções cruciais, incluindo a absorção de nutrientes, regulação imunológica, proteção contra patógenos e preservação da integridade da barreira intestinal. Além disso, exercem influência sobre o desenvolvimento e a função do cérebro e do sistema nervoso. A composição da microbiota é influenciada por uma variedade de fatores, tais como genética, dieta, níveis de estresse, estilo de vida e o uso de medicamentos, notadamente antibióticos. Compreender esses fatores é fundamental para a manutenção de uma microbiota saudável. Pesquisas indicam que desequilíbrios nessa comunidade microbiana estão associados a condições de saúde adversas, incluindo obesidade, diabetes e doença inflamatória intestinal. Consequentemente, destaca-se a importância da educação para a sociedade, visando a conscientização sobre a adoção de hábitos de vida saudáveis. Reduzir o uso desnecessário de antibióticos e incorporar alimentos prebióticos e probióticos na dieta são medidas cruciais para promover uma microbiota intestinal equilibrada e, por conseguinte, contribuir para a prevenção de doenças relacionadas a desequilíbrios microbiológicos.
ANESTESIA DE GATAS SUBMETIDAS À OVARIOHISTERECTOMIA EM CLÍNICAS VETERINÁRIAS SOCIAIS
Authors: Leitzke Arthur Venicius Sbaraini , Borges Talita Bianchin , Tramontin Rafael Santos , Maia Luan Vinicius Tezzei , Dissenha Adrielly , Belettini Salviano Tramontin , Boscarato André Giarola , Rosina Leonardo Matheus Jagelski , Broch Natália Regina Alexandrino , De Sá Thaís Camaso , Coltro Mariana , Quessada Ana Maria
Published: April 2024

Este artigo tem por objetivo realizar uma revisão de literatura sobre anestesia de gatas submetidas à ovariohisterectomia em clínicas veterinárias sociais. Para isso, foi realizada uma busca em sites de literatura científica utilizando-se termos pertinentes ao tema. Por meio de tal busca foi possível concluir que na anestesia de gatas submetidas à ovariohisterectomia é importante selecionar protocolos anestésicos seguros. Atualmente, as clínicas que atendem tutores de baixa renda atendem à comunidade realizando castração em cães e gatos, contribuindo para a qualidade de vida e bem-estar dos animais e impactando na saúde única.
ВЛИЯНИЕ ПОЛИМЕРНОЙ МОДИФИКАЦИИ УДОБРЕНИЙ НА РАЗВИТИЕ КОРНЕВОЙ СИСТЕМЫ РАСТЕНИЙ ЗЕМЛЯНИКИ: СРАВНИТЕЛЬНЫЙ АНАЛИЗ МЕЖДУ АЗОФОСКОЙ УНИВЕРСАЛЬНОЙ, TAGROW И OSMOCOTE PRO
Authors: Арсанов М.М. , Мутаев И.А. , Сириева Я.Н.
Published: April 2024

Современное сельское хозяйство стоит перед вызовом импортозамещения, особенно в области агрохимии. В этом контексте разработана новая методика производства удобрения пролонгированного действия под названием "Азофоска универсальная" с содержанием азота (N16), фосфора (P16) и калия (K16), реализуемая путем нанесения биоразлагаемого полимера в концентрации 3% и 6%. Проведенные эксперименты в условиях теплиц на культуре земляники показали, что разработанная форма удобрения не только не уступает, но и превосходит известные зарубежные аналоги, такие как Tagrow и Osmocote Pro, по показателям высвобождения минеральных веществ в почву. Это открывает перспективы для создания собственных конкурентоспособных продуктов в области агрохимии, способствуя национальной экономике и обеспечивая устойчивость сельскохозяйственного производства.
NEUROCIRURGIA DE EMERGÊNCIA EM PACIENTES COM TRAUMATISMO CRANIOENCEFÁLICO GRAVE
Authors: Italo Samuel Alves dos Santos  , Lucas Dantas de Sousa  , Istefane Alves dos santos  , Gabriel Marcos Botelho Ferraz Mendes  , Flávia de Araújo Costa  , Isabelle Oliveira Macêda  , Albenio Jonatas da Silva Pereira  , Samela da Silva oliveira  , João Felipe Mahfus  , Bárbara de Melo Pinto  , Lucas Messias Caze Rodrigues  , Tomas Bruneto
Published: April 2024

O traumatismo cranioencefálico (TCE) é um importante problema de saúde pública, com muitas vítimas acometidas ainda em fase produtiva de vida, gerando um importante impacto econômico e social. O objetivo do trabalho é mostrar o perfil epidemiológico e clínico dos pacientes vítimas de TCE atendidos em um grande hospital público de urgência e emergência e alertar médicos e estudantes de medicina sobre a importância do registro adequado de dados para fins epidemiológicos. Para realização da pesquisa foi ana- lisado a retrospectiva de prontuários de pacientes vítimas de TCE internados no Hospital Dr. Jayme Santos Neves, Serra, ES, entre 2015 e 2016. A análise corroborou achados prévios de literatura, com predomínio do sexo masculino e de traumatismos leves. Os mecanismos mais frequentemente observados foram a queda da própria altura, acidentes motociclísticos, quedas de um nível ao outro e agressões. Apesar do esforço de campanhas públicas, principalmente voltadas para segurança no trânsito, observou-se ainda um número elevado de pacientes com TCE graves. O estudo dos mecanismos mais prevalentes chama a atenção para a necessidade de desenvolvimento de campanhas específicas para determinados grupos de risco, como motoqueiros, ciclistas e idosos com risco de queda. Há ainda uma escassez de estudos epidemiológicos em língua portuguesa sobre o tema, tornando difícil a avaliação do impacto destas medidas de prevenção sobre a morbidade e mortalidade deste tipo de trauma.
DOENÇAS CARDIOVASCULARES EM UM ASPECTO NA SAÚDE COLETIVA: REVISÃO DE LITERATURA
Authors: Marcel Guedes Pinto  , Victor Durier Cavalcanti de Almeida  , Viviane Chicourel Hipólito Rodrigues  , Joanderson do Nascimento Silva  , Rafael Xavier França  , Flávia Santos Pinheiro  , Thais cordeiro dos santos  , Thaís Cordeiro Brito  , Loyane Gomes Alves Stenzel  , Raquel Chagas Oliveira  , Thiago Queiroz Pires  , Sirleila Dantas Canário  , Marcelo Sanches Souza  , Ivana Rodrigues Santos Penedo  , Carolina Wogeley Oliveira Silva
Published: April 2024

O objetivo deste artigo é analisar e apresentar uma compreensão aprofundada dos desafios contemporâneos na gestão de doenças cardiovasculares, com uma ênfase especial na perspectiva de saúde coletiva. Buscando identificar e discutir os fatores que contribuem para a complexidade da gestão dessas doenças, considerando as nuances epidemiológicas, sociais e tecnológicas. Metodologia: Trata-se de uma revisão bibliográfica abrangente da literatura científica em bases de dados como PubMed, Scielo, Latindex e Medline. Com a utilização dos DeCs (descritores de saúde): “Cardiology”; “Public Health”; Health-Disease Process”. Sem restrições de tempo e de metrologia. Resultados: Exploração de como a abordagem de saúde coletiva pode oferecer insights valiosos e estratégias inovadoras para enfrentar esses desafios. A integração de cuidados, a aplicação de tecnologias em saúde e a promoção da equidade são elementos cruciais que serão abordados à luz da perspectiva coletiva, visando proporcionar uma visão holística e eficaz na gestão dessas condições. Conclusão: Em suma, proporcionou-se uma análise aprofundada dos desafios contemporâneos na gestão de doenças cardiovasculares, destacando a perspectiva crucial da saúde coletiva. Ao explorar fatores epidemiológicos, sociais e tecnológicos, identificamos a complexidade envolvida na gestão dessas condições. A abordagem coletiva, integrando cuidados, tecnologia e promovendo a equidade, emerge como uma estratégia fundamental para enfrentar esses desafios e promover uma gestão mais eficaz e abrangente das doenças cardiovasculares.
ABORDAGEM INICIAL DAS INTOXICAÇÕES AGUDAS
Authors: Laiz Rosa e Andrade  , João Pedro Pereira de Morais  , José Alef Bezerra Ferreira  , Alan Guillermo Avila Westry  , Sara dos Santos Silva  , João Guilherme de Holanda Melo  , Lilian Fonseca Clementele  , Ana Luiza Rilko Mattar  , Ana Gabriela Mascarenhas da Silva Teixeira  , Victor Tadeu Tavares De Almeida  , Catharina Carvalho Santana  , Keyla Liana Bezerra Machado  , Thiago Ruam Nascimento
Published: April 2024

A intoxicação aguda ocorre quando uma substância tóxica é ingerida, inalada ou absorvida em quantidades suficientes para causar sintomas agudos, sendo que os sintomas podem variar amplamente dependendo da substância envolvida. A avaliação inicial de um paciente com suspeita de intoxicação aguda requer um conjunto de habilidades clínicas e conhecimento detalhado, uma vez que muitas vezes a natureza da substância e a quantidade envolvida não são imediatamente evidentes. Objetivo: Investigar e aprofundar o conhecimento sobre as estratégias, protocolos, técnicas e melhores práticas de abordagem inicial em casos de intoxicações agudas, com foco na avaliação clínica, diagnóstico, tratamento de emergência e prevenção. Metodologia: Realizou-se uma revisão integrativa, mediante um levantamento de dados nas bases: LILACS e BDENF. Resultados e Dis- cussões: Os resultados indicam que, além da história, a avaliação física detalhada e a aplicação de ferramentas clínicas apropriadas desempenham um papel vital na identificação de sinais e sintomas associados à intoxicação aguda. Protocolos clínicos específicos que enfatizam a monitorização de sinais vitais, avaliação neurológica e exames laboratoriais, quando indicados, contribuem para um diagnóstico mais preciso e uma abordagem terapêutica direcionada. A investigação também destacou a importância de um tratamento de emergência rápido e eficaz. A administração de antídotos espe- cíficos e terapias de suporte, como medidas para prevenir a absorção contínua da substância tóxica, mostrou-se essencial para a recuperação do paciente. A administração de terapias desintoxicantes, como a administração de carvão ativado, em casos apropriados, pode reduzir significativamente a absorção de substâncias tóxicas. Conclusão: Em última análise, a pesquisa reforça a importância da colaboração entre profissionais de saúde, toxicologistas, especialistas em medicina de emergência e saúde pública para enfrentar eficazmente o desafio das intoxicações agudas. A abordagem inicial dessas situações requer uma resposta rápida, coordenada e baseada em evidências para garantir a segurança e o bem-estar dos pacientes.
IDENTIFICATION OF THREATS TO RUSSIA’S NATIONAL SECURITY AND SOVEREIGNTY
Authors:   Baltic State Technical University “VOENMEH” named after D. F. Ustinov, Saint Petersburg, Russia, Kozlov Leonid A.
Published: April 2024

Today, the problem of threats to the economic security of countries caused by globalization is becoming increasingly important. These changes require a new assessment and identification of the most significant threats and the search for ways to overcome them. Regardless of the level of economic development of the country, the occurrence of negative effects of destabilizing factors in the internal or external environment is quite obvious. World experience shows that the degree of negative impact of threats to the economic security of the state can be minimized if there is a clear strategic plan for the development of the national economy, which defines the main directions of state policy to eliminate external and internal threats to the economic security of the state
МОНІТОРИНГ МЕРЕЖІ ПОСТІВ КОНТРОЛЮ ДЖЕРЕЛ
ЗАБРУДНИКІВ ПОВІТРЯ
Authors: Доровський Д.В.
Published: April 2024

Постановка задачі аналізу структури мережі моніторингу та розміщення стаціонарних
постів. Моніторинг стаціонарних джерел забруднювача частково може проводитися з використанням стаціонарних постів контролю стану повітря. У зв›язку з високою вартістю впровадження та експлуатації таких постів, а також стохастичним характером поширення домішки в
атмосфері ефективність роботи групи стаціонарних постів регіону істотно залежить від розташування їх у просторі. Необхідною умовою успішного проведення заходів щодо зниження концентрації шкідливих викидів у навколишнє середовище та робіт з охорони чистоти атмосфери
є контроль стану атмосферного повітря, що дає об›єктивну оцінку працездатності та ефективності всієї діяльності запобігати забрудненню навколишнього середовища. Сформульовано
завдання аналізу структури мережі стаціонарних постів спостереження атмосферного повітря
з метою підвищення якості поінформованості про забруднення за мінімальних витрат. Вперше
запропоновано метод розміщення мережі постів спостереження, заснований на відомих моделях розсіювання домішки в атмосфері, теорії про регіоналізовану змінну та методи кригінгу
для отримання адекватних оцінок про викиди стаціонарних техногенних джерел емісії домішки.