bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of the Wnt/β-catenin pathway inhibitors on cell proliferation and migration of HEC-1A endometrial adenocarcinoma: experimental cell culture model
Authors: ÇİRÇİRCİ Yaşam , TİFTİK R. Nalan , ÜN İsmail
Published: April 2021

Objectives: The most diagnosed tumor among infiltrating tumors of the female genital tract is endometrial carcinoma. The Wnt/β-catenin signaling pathway has an important role in organogenesis, self-renewal of tissues, and adult stem cell maintenance. However aberrant activation of it causes many types of tumors and also related to the prognosis of patients. Therefore, we aimed to investigate whether Wnt/β-catenin pathway inhibitors have any effect on the proliferation and migration of tumor cells.
Methods: As cancer cell line, HEC-1A endometrial adenocarcinoma was used. The Wnt/β-catenin pathway inhibitors effects on proliferation and migration were demonstrated by real-time cell analysis device and wound healing model respectively.
Results: Wnt/β-catenin pathway inhibitors FH535 (25 μM at 36th hour, p < 0.05; 50μM at 48th hour p < 0.001) and niclosamide inhibited cell proliferation (10, 25 and 50μM at 60th hours; p < 0.01, p < 0.05 and p < 0.001, respectively) whereas ICRT14 and IWP-2 did not. However only niclosamide which is also an antihelmintic drug inhibited migration of the cells in all concentrations tested (10, 25 and 50μM, p < 0.05).
Conclusions: The present study shows that the Wnt/β-catenin pathway has an substantial role in both proliferation and migration of endometrial adenocarcinoma. We suggest that the antihelmintic drug niclosamide could be further investigated for its potential therapeutic effect in endometrial adenocarcinoma.
La cultura como investidura, la historia como subjetividad
Authors: Guarás María Cecilia
Published: April 2021

Este artículo busca reflexionar sobre la construcción de la narrativa vestimentaria personal, a partir de la reconstrucción de la historia familiar heredada. Paralelizar el recuerdo y el material tangible poniéndolos en diálogo en un contexto diferente al del hecho en sí, actualizado a través de un receptor contemporáneo. Se busca, a su vez, reflexionar sobre la superposición de las temporalidades que se encarnan en memorias y materialidades, escritas en una línea de tiempo y contada a través de relatos escritos, matéricos o hablados. Esta historia escuchada en los relatos, leída en las cartas y observada en las fotografías, se transforma en una investidura que abraza al receptor dotándolo de significado, conteniéndolo, vistiéndolo y componiéndolo más allá de su contemporaneidad. A partir de esta conceptualización se busca analizar la práctica vestimentaria como acto simbólico que trae a un tiempo presente, una herencia cultural que se resignifica de generación en generación. Se pretende analizar el concepto de historia/relato como subjetividad reflexionando sobre la reconstrucción simbólica de lo comprendido como cultura familiar. A partir de relatos, fotografías y objetos de uso cotidiano ya apartados de quienes los poseyeron con anterioridad, profundizar sobre la reconstrucción emocional de la historia contada de nuestros antepasados, como quien elige cada día de su guardarropas una prenda cada día, en este artículo se retomará el eco de algunas historias que han subsistido varias generaciones. Este artículo se construye a partir del desarrollo de “Herencia” una cápsula upcycled de indumentaria realizada por quien lo escribe, en un viaje en tiempo y espacio hacia los antepasados familiares.
La trama en el espacio tridimensional. La aplicación de un recurso gráfico complementario en el nuevo edificio de la Fondation Louis Vuitton
Authors: Spina María Laura
Published: April 2021

En el diseño de un Sistema de Identidad Visual de Alta Complejidad, el uso y aplicación de un repertorio de identificadores secundarios otorga valor a la identidad misma.

La aplicación de tramas bidimensionales aplicadas a espacios tridimensionales impacta eficazmente en la identidad de la empresa, resignificando el propio Sistema Visual convirtiendo al espacio arquitectónico en un hito señalético corporativo dentro del Programa Tridimensional.

Actualmente, marcas de Indumentaria reconocidas, recurren al dominio del espacio bitridimensional con el objetivo de convertirse en símbolos gráficos universales de alto poder de recordación dentro de un espacio urbano.
Choice of Law in Latin American Arbitration: Some Empirical Evidence and Reflections on the Latin American Market for Contracts
Authors: Cuniberti Gilles , José Segovia González Manuel José
Published: April 2021

The aim of this Article is to assess the preferences of parties to Latin American international business transactions when they choose the law governing their contracts. For that purpose, the authors have conducted an empirical analysis of data that they were able to gather from arbitral institutions active in Latin America, with a focus on years 2011 and 2012. Furthermore they offer some reflections on the results and elaborate on whether they can be explained by the territorial approach of choice of law in Latin America, the importance of the United States as a trading partner for Latin American countries and the extent to which Anglo-American lawyers are present on Latin American markets.
Arbitraje comercial internacional y tutela cautelar: colaboración entre jueces y árbitros en la adopción y reconocimiento de medidas cautelares internacionales
Authors: Sueiro Varhen Víctor Rogelio
Published: April 2021

En el Perú, al referirnos al arbitraje comercial internacional, encontramos dos interrogantes que, hasta el momento, han merecido escasa reflexión doctrinaria. Estas son, por un lado, la posibilidad de que un tribunal peruano adopte una medida cautelar en auxilio de un arbitraje comercial con sede en el extranjero; y, de otro lado, la posibilidad de reconocimiento por los tribunales peruanos de una medida cautelar dictada en el ámbito de un arbitraje comercial con sede en el extranjero. Son las dos caras de un mismo problema al que el autor, sobre la base de una sólida argumentación, busca dar respuesta. En el presente artículo, el autor inicia su análisis a partir de la importancia del derecho a la tutela jurisdiccional internacional efectiva, con énfasis en la tutela cautelar internacional. Posteriormente, aborda el deber de cooperación de los tribunales estatales para salvaguardar la eficacia de la tutela cautelar en el arbitraje comercial internacional. Finalmente, el autor propone ciertos criterios o parámetros que resultarán útiles para los tribunales es-tatales peruanos a fin de que puedan adoptar y reconocer medidas cautelares en apoyo a un arbitraje comercial internacional con sede en el extranjero.
Árbitro de emergencia: el refuerzo de la tutela cautelar (ante causam) en el arbitraje institucional
Authors: Blanco García Ana Isabel
Published: April 2021

El presente artículo busca poner en valor la labor que las instituciones arbitrales están acometiendo para garantizar una tutela arbitral integral, especialmente en lo que concierne a la adopción de medidas cautelares, incluyendo las llamadas medidas cautelares ante causam. Medidas que, como su nombre bien indica, son solicitadas incluso antes que la demanda, lo que en la práctica se traduce en la ausencia de órgano arbitral; puesto que no ha sido, todavía, constituido formalmente. La figura del árbitro de emergencia surge para dar respuesta a dicha necesidad, evitando que la decisión sobre este tipo de medidas quede en manos de los órganos jurisdiccionales, sobre todo por las dificultades que podría llegar a presentar la determinación de la competencia en los arbitrajes internacionales.
Apuntes respecto de la validez de los acuerdos procesales que condicionan el acceso a la anulación de laudo a la constitución de una garantía en el ordenamiento jurídico peruano
Authors: Campos García Héctor
Published: April 2021

En el ordenamiento jurídico peruano es posible que las partes celebren acuerdos procesales que condicionen el acceso a la anulación del laudo arbitral a la constitución de una garantía. Dichos acuerdos procesales no vulneran disposiciones legislativas, ni disposiciones constitucionales vigentes. Adicionalmente, poseen reconocimiento legislativo expreso en la Ley de Arbitraje peruana. Sin embargo, los acuerdos procesales tienen límites concretos, que en caso ser vulnerados generan la nulidad de estos mismos.En el presente artículo, el autor evalúa si los particulares pueden establecer válidamente un acuerdo en el que se condicione el acceso a la anulación del laudo arbitral con la constitución de una garantía. En ese sentido, presenta, de forma crítica, las principales posiciones que se han planteado a favor y en contra de la validez del ámbito estudiado, para demostrar su hipótesis inicial.
¿La rapidez o flexibilidad?: Un análisis económico de la ampliación de plazos en el arbitraje
Authors: Silva Longobardi Paula , Moreno Machín Valeria
Published: April 2021

Una de las grandes similitudes entre un proceso judicial ordinario y uno arbitral es que ambos toman tiempo. No obstante, en el arbitraje se presentan medidas que, a diferencia de los procesos judiciales, tienen la finalidad de responder a un adecuado uso de este recurso en el proceso. En términos generales, los criterios legales vigentes para otorgar ampliaciones de plazo en el arbitraje son el de igualdad de armas o de oportunidades y el de la razonabilidad, recogidos en la Ley de Arbitraje peruana.En el presente artículo, las autoras revisan la suficiencia de estos criterios desde el Análisis Económico del Derecho para cada una de las fases del proceso arbitral y, de tal forma, proponen su uso como enfoque para la evaluación de la razonabilidad al momento de tener que decidir si dar o no una prórroga en el proceso en cuestión.
La doble nacionalidad de personas naturales en el arbitraje de inversiones de Venezuela
Authors: Anzola J. Eloy
Published: April 2021

Los APPRI son acuerdos bilaterales que buscan promover y proteger las inversiones de los naturales de un Estado signatario en el territorio del otro Estado contratante. Entre sus disposiciones, suelen pactarse cláusulas de compensación frente a potenciales controversias sobre expropiación que surjan entre los inversores y los Estados receptores. De esta manera, es necesario que esta persona sea natural de uno de los Estados suscriptores para que sea compensada por cualquier pérdida o daño que sufra en relación con las inversiones protegidas. En esa medida, la cuestión principal subyace en determinar si este tipo de acuerdo bilateral debería proteger también a los inversores binacionales. Además, es necesario cuestionarnos si el criterio jurisprudencial es uniforme frente a este tipo de controversias. En este artículo, el autor analiza la aplicación de algunos de estos tratados celebrados por Venezuela, así como la evolución de los criterios que han adoptado los tribunales arbitrales y las cortes. Con este objetivo, desarrolla el curso de tres casos relevantes contra este Estado para resaltar cómo ha evolucionado el debate sobre la posición de los APPRI dentro del Derecho Internacional, la alegada falta de jurisdicción de los tribunales para pronunciarse y la naturaleza del inversor y su nacionalidad dominante.
Bear Creek V. Peru and the Legality of the Investment as a (Implied) Requirement for the Investment Arbitration Tribunal’s Exercise of Jurisdiction
Authors: Talavera Cano Andrés
Published: April 2021

Concerns about inconsistency in the application of standards in arbitral awards are strongly present in investment treaty arbitration. In particular, tribunals can regularly exercise a varying scope of jurisdiction when they determine the legality requirement that demands foreign investments to be made in accordance with the law of the host state.In this paper, the author seeks to analyze the decision rendered by the tribunal in Bear Creek v. Peru, in which the Canadian mining company alleged that the Peruvian State breach, inter alia, expropriation protections under the Canada-Peru Free Trade Agreement in relation to its investment in the silver mining project of Santa Ana. In order to achieve this aim, in the first chapter, he addresses three key issues regarding the tribunal’s jurisdiction, the rights on which the company based its claim and the arguably prerequisite of legality or good faith for the tribunal’s exercise of jurisdiction. In the second chapter, he analyzes the validity of the tribunal’s interpretation on the legality requirement for investment as an implicit element in the relevant treaty to determine the tribunal’s jurisdiction.
Corrupción en arbitraje internacional de inversiones: ¿es un peligro o un salvavidas para países en desarrollo?
Authors: Alvarez Calderón Campos Andrés
Published: April 2021

En los últimos años, las alegaciones de corrupción en los arbitrajes de inversión han aumentado considerablemente. Al ser utilizadas por los Estados, tales alegaciones tienen por objeto el rechazo de las reclamaciones de inversionistas por falta de jurisdicción de los tribunales, en base a la existencia de corrupción dentro de la inversión. Sin embargo, no existe uniformidad en el criterio adoptado por los tribunales de inversión, pues la participación del Estado en los hechos de corrupción puede jugar un rol fundamental en la decisión.En el presente artículo, el autor analiza los principales argumentos de defensa utilizados por los Estados al alegar la existencia de corrupción y desarrolla los distintos criterios adoptados por los tribunales de inversión frente a tales alegaciones. Adicionalmente, propone un test que los tribunales pueden aplicar para decidir el efecto que los hechos de corrupción alegados generen en el arbitraje.
Importando paraguas: las cláusulas de nación más favorecida y cláusulas paraguas en el arbitraje de inversión
Authors: De la Flor Puccinelli Nicolás , Quiroz Arellano Matias
Published: April 2021

El Derecho Internacional de las Inversiones hoy en día se encuentra caracterizado por la fragmentación. Esto se debe principalmente a los diferentes estándares de garantía que los Estados otorgan a los inversionistas extranjeros, así como a las decisiones arbitrales al respecto. Si bien cada estándar de protección debe analizarse en cada caso concreto, la doctrina y los Tribunales internacionales han reconocido la existencia de ciertos estándares de protección clásicos como las Cláusulas de Nación Más Favorecida o las denominadas Cláusulas Paraguas. En el presente artículo, los autores buscan desarrollar la forma en que suelen operar estos dos estándares de protección y la posibilidad de invocar los beneficios de la cláusula paraguas por medio de una aplicación de la cláusula de nación más favorecida, de acuerdo a lo que ha sido resuelto por la jurisprudencia internacional sobre la materia.
El Aporte por Regulación a favor del OEFA bajo la lupa: ¿transgresión al principio de no confiscatoriedad?
Authors: Rodrigo Rohrhirsch Lucía
Published: April 2021

Uno de los principios que limitan la potestad tributaria es el principio de no confiscatoriedad. En el año 2019, el Tribunal Constitucional debatió los alcances del mencionado principio en la sentencia que declaró infundada la demanda de amparo interpuesta por una empresa minera que solicitó la inaplicación del Decreto Supremo 130-2013-PCM, por vulnerar los principios de no confiscatoriedad, legalidad y reserva de ley. En el presente artículo, la autora analiza si el Aporte por Regulación a favor del OEFA vulnera el principio de no confiscatoriedad y para ello, explica qué tipos de tributo se encuentran regulados en el ordenamiento jurídico peruano y cuál es el tratamiento legal que se ha establecido para cada tipo. Asimismo, expone brevemente algunos comentarios en relación con la sentencia del Tribunal Constitucional.
Gestión de los bienes propios en la sociedad de gananciales: una visión crítica
Authors: Santillán Santa Cruz Romina
Published: April 2021

La sociedad de gananciales es un régimen de comunidad relativa. Se configura legalmente por la existencia de bienes comunes de los cónyuges, sin perjuicio de que, durante su vigencia, cada uno pueda tener bienes propios. Se genera, entonces, un entramado de situaciones jurídicas que emergen de la gestión de dichos bienes. La gestión de los bienes propios está presidida por una regla de libre actuación de los cónyuges. Por ello, no existen límites expresos a los actos de administración y disposición de estos bienes. Sin embargo, ello no significa que no los haya.En el presente artículo, la autora se centra en el estudio de las restricciones legales y límites implícitos que resultarían aplicables a la gestión de los bienes propios en la sociedad de gananciales en el ordenamiento jurídico peruano. En ese sentido, analiza también la figura de la irrenunciabilidad unilateral de actos de liberalidad, pues parece ser la única excepción prevista a la regla de libre actuación.
Histology of Hair Follicles in Different Breeds of Rabbits
Authors: Lucy K.M. , Ashok N. , Maya S. , Indu V.R. , Sreeranjini A.R. , Karthiayini K.
Published: April 2021

Background: Rabbit farming provides a valuable additional source of income in the rural areas of the county. Skin is the largest organ in the body and the hair coat forms the first line of defense against the invading pathogenic organisms as well as the physical environment. So far, no detailed comparative study has been conducted on the skin of various breeds of rabbits. Hence, the present work was undertaken to compare the structure and distribution of hair follicles in different breeds of rabbits commonly reared in Kerala. Methods: The study was conducted on the skin of six breeds of rabbits namely, Soviet Chinchilla, New Zealand White, Grey Giant, White Giant, Angora and crossbred. In total, 36 animals were used for the study. From each animal, skin samples were collected from eight representative areas of the body viz., dorsal nasal region, pinna, dorsal neck, dorsal thorax, dorsal abdomen, ventral abdomen, perineal and carpal regions. Standard procedures were adopted for histological studies. Result: All the six breeds of rabbits showed compound hair follicles with primary and secondary follicles with associated sebaceous glands. Arrangement of hair follicles showed differences among the breeds. There was no difference in the histology of hair/hair follicle among the breeds. This work will form a basis for further breed specific research in the area of fur and leather industry and skin penetration studies.
TIBBI VE AROMATİK BİTKİ ÜRETİM MİKTARINI ETKİLEYEN FAKTÖRLERİN İSTATİSTİK TEKNİKLERLE ARAŞTIRILMASI VE ÜRETİM MİKTARININ TAHMİNLENMESİ
Authors: CAN Şengül
Published: April 2021

Bu çalışma ile, yıllık tıbbi ve aromatik bitki üretim miktarı üzerinde etkisi olduğu düşünülen değişkenlerin yıllık üretim miktarını ne yönde etkiledikleri araştırılmıştır. Küresel ekonomide önemli bir yeri olan ve ülkemiz iklim koşulları nedeniyle doğal olarak yetişen pek çok bitki türü bulunmaktadır. Tıbbi ve aromatik bitkiler ise ülkemizde daha çok doğadan toplama yoluyla üretilmektedir. Ancak dünya geneline bakıldığında tıbbi ve aromatik bitkilerin endüstriyel ve alternatif tıp amaçlı kullanımının yaygınlaştığı görülmektedir. Bu nedenle ülkemiz üretim miktarı üzerinde etkisi olan faktörlerin değerlendirilerek yerli üretimin nasıl teşvik edilebileceği regresyon analizi tekniği kullanılarak araştırılmıştır. Sıcaklık, yağış, fiyat, döviz alış kuru ve döviz satış kuru değişkenlerinin üretim miktarı üzerindeki etkisinin araştırıldığı model (p=0.000
Assessment of Radical Scavenging and Sickling Inhibitory Activities of the Bark of Disthemonanthus Benthamianus (Caesalpiniaceae)
Authors: JoÃ«l Akakpo-Akue , Marcel Ahon Gnamien , Kangah Mireille KplÃ© Tatiana , Yvette FofiÃ© , Sanogo Ibrahime , Claire Chiyae Yapo-Crezoit Antoinette , Koffi Mathieu Kra Adou
Published: April 2021

Among the medicinal plants used in the treatment of sickle cell disease in south-east of CÃ´te d'Ivoire is Disthemonanthus benthamianus. This paper focuses on assessing its antioxidant properties and its antisickling activity. The test of inhibition of sodium metabisulfite-induced sickling of the erythrocytes was carried out based on this evaluation. The total phenolic compounds contents were 45 Â± 0.64 and 39.84 Â± 0.69 mg/g of dry weight for ethanolic extract and the decocted respectively. The DPPH reduction test showed that the decocted (9 Î¼g/mL) had a lower IC50 than the ethanolic extract (16 Î¼g/mL). There was no significant difference between the sickling inhibitory activities of the ethanolic extract (87.00%) and the decocted (81.66%). This study showed that both extracts had sickling inhibitory and antioxidant activities.
Iconography as a Means of Reaching Political Power: A Case Study of Three Georgian Presidents
Authors: Aptsiauri Giorgi
Published: April 2021

This paper focuses on analyzing the structure of political iconography as one of the methods to achieve political power. On this basis, the political iconography of three Georgian presidents is analyzed. In the modern world, the most important tool for politics and politicians is creating a political icon. Political iconography is directly connected with Christian iconography. It is widely known that in order to get the desired impact on the society, various forms and means of mass communication are used such as personal, social, visual, rhetoric, audio, and communication. Using them without creating iconographic image from politicians does not have any result. Political iconography reaches and mostly remains in the mind of the society, and this leads people to make their decision to support the politician who is a hero of the iconography. This fits the narrative, meaning, and common discourse of the society, which formed an iconographic image of the certain politician. After the collapse of the Soviet Union, a new type of political iconography of Georgia was born which is essentially different from the Soviet iconography. The political iconography of these three Georgian presidents is based on the narrative of creating a modern state. There is however a substantial difference between them. Zviad Gamsakhurdia created the political iconography of a savior, Edward Shevardnadze was seen as an iconic politician, and Mikheil Saakashvili was a creator of power and savior.
El Capital Intelectual y su Incidencia en la ProducciÃ³n de las Empresas Productoras de Banano en la Costa sur del Ecuador
Authors: Jaya Pineda Iddar IvÃ¡n , Plaza GuzmÃ¡n Jorge Javier , Novillo Maldonado Ernesto
Published: April 2021

El presente trabajo de investigaciÃ³n se lo realizÃ³ por el entorno extremadamente competitivo en el Ã¡rea agrÃ­cola exigiendo a las empresas productoras de banano un esfuerzo constante en la mejora de sus procesos de producciÃ³n, comercializaciÃ³n, gestiÃ³n y direcciÃ³n econÃ³mica con un capital de talento humano calificado en el Ã¡rea de siembra y administraciÃ³n de las fincas. De esta manera los pequeÃ±os productores de banano tradicional se han visto obligados a depender cada vez mÃ¡s de la informaciÃ³n tÃ©cnica en el Ã¡rea agrÃ­cola, administrativa financiera proporcionada por un capital intelectual humano de alto nivel que toma como base objetiva ejercer una funciÃ³n vital: la toma de decisiones, donde se aprecia que las agrÃ­colas de economÃ­a familiar carecen de un capital intelectual idÃ³neo para ejercer esta funciÃ³n, a diferencia de las fincas asociadas que su visiÃ³n estÃ¡ orientando para insertarse y permanecer en el mercado bananero con productos de calidad, con volÃºmenes y periodicidad demandada, que permitan el desarrollo sostenible de la organizaciÃ³n, en el mercado interno como internacional, dando prioridad en los estÃ¡ndar de calidad en la fruta de exportaciÃ³n.
 
This paper was carried out due to the extremely competitive environment in the agricultural area. This requires the banana-producing companies to make a constant effort to improve their production, marketing, management, and economic management processes with a capital of qualified human talent in the area of sowing and administration of the farms. Through this way, small traditional banana producers have been forced to rely more and more on technical information in the agricultural, administrative, and financial area provided by a high-level human intellectual capital. This gave rise to the objective of performing a vital function, which is decision-making. Here, it can be seen that family farmers lack the ideal intellectual capital to exercise this function. This is unlike the associated farms where their vision is guiding to insert and remain in the banana market with quality products, with volumes and demanded periodicity. This has also led to the sustainable development of the organization, in the domestic and international markets, by giving priority to quality standards in export fruit.
Extração de compostos bioativos do flavedo/albedo e da farinha do pomelo submetida a diferentes processamentos
Authors: Rodrigues Damiane Oliveira Barbosa , Guimarães Rita de Cássia Avellaneda , Bogo Danielle
Published: April 2021

Citrus paradisi Macfad são uma excelente fonte de nutrientes e de fitoquímicos importantes para uma dieta saudável. Nesse contexto, o conhecimento da composição química dos alimentos é fundamental para avaliar os teores de nutrientes e os seus benefícios para a saúde. Entretanto, um dos problemas relacionados ao consumo do pomelo é o sabor amargo proveniente da naringina que apresenta na casca, tornando-se importante desenvolver uma farinha com teor reduzido de sabor amargo. As determinações foram realizadas na casca, no flavedo e no albedo, na farinha obtida por processamento térmico de 48 horas, na farinha por processamento térmico de 72 horas, na farinha processada e lavada em água fria e na farinha triturada, lavada em água fria e processada. Para determinação de ácido ascórbico, utilizou-se o método titulométrico, e os demais bioativos foram determinados por espectrofotometria. Os extratos aquoso, hidroacetônico e etanólico foram utilizados na determinação dos compostos fenólicos totais, taninos totais. A atividade antioxidante DPPH foi determinada pelo método fotocolorimétrico. A farinha com processamento térmico de 72 horas teve diminuição da concentração dos bioativos, e a farinha obtida pela casca e albedo triturados antes do processo de obtenção teve as maiores concentrações, ressaltando um aumento discrepante de ácido ascórbico em relação às outras. O teor de carotenoides não teve diferenças significativas entre as amostras. Entre todos os tratamentos, a farinha obtida por processamento em água fria, sem ser triturada antes da obtenção, é que teve redução do sabor amargo da naringina.
Native American Homelessness and Minneapolis’ Infamous Tent City: Dispelling Myths and Stereotypes to Uncover Solutions
Authors: Jackson Jeanine R. , Fashant Crystal Saric
Published: April 2021

In the summer of 2018, an affordable housing crisis in Minneapolis, Minnesota led to the erection of a homeless encampment infamously labeled, “Tent City.” Publicized by media as a camp for homeless Native Americans, pervasive myths and stereotypes filled the airwaves while public agencies and nonprofit organizations raced to find solutions to this community crisis before the cold winter months settled in. Written from the perspective of an Indigenous woman working in the social services sector of Minneapolis, along with her faculty advisor in a public and nonprofit graduate program, this article: 1) identifies issues of homelessness in Native American communities, 2) dispels myths and stereotypes about Native Americans that impede meaningful progress, 3) explores barriers to safe and secure housing for Native Americans and other marginalized communities, 4) identifies states and countries leading the way to solve homelessness, and 5) suggests best practices and solutions to the ongoing homelessness crisis.
The Managerial Apprenticeship of FDR’s Budget Director: Harold D. Smith and the Michigan Municipal League, 1928–1937
Authors: Lee Mordecai
Published: April 2021

Public administration history often notes the seminal role of Harold D. Smith, FDR’s budget director (1939–1945), in the professionalization of the field and his principles for public budgeting. He was a cofounder of the American Society for Public Administration (ASPA) and its second president (1940–1941). Smith came to Washington after a longer career in nonprofit management. This exploratory historical case study fills in a gap in the literature. Specifically, it examines his nonprofit management record at the Michigan Municipal League (1928–1937). He successfully grew the nonprofit in the teeth of the Great Depression. This success, among others, can be seen as providing two possible applications. First, his record suggests some commonalities between nonprofit management and public administration. Second, leading a nonprofit during the Great Depression may suggest applicable lessons for longer-term problems caused by COVID-19 regarding organizational management strategies during another severe economic contraction.
COVID-Well Study: Qualitative Evaluation of Supported Wellbeing Centres and Psychological First Aid for Healthcare Workers During the COVID-19 Pandemic
Authors: Blake Holly , Gupta Alisha , Javed Mahnoor , Wood Ben , Knowles Steph , Coyne Emma , Cooper Joanne
Published: April 2021

Supported wellbeing centres were set up in UK hospital trusts as an early intervention aimed at mitigating the psychological impact of COVID-19 on healthcare workers. These provided high quality rest spaces with peer-to-peer psychological support provided by National Health Service (NHS) staff volunteers called ‘wellbeing buddies’, trained in psychological first aid. The aim of the study was to explore the views of centre visitors and operational staff towards this COVID-19 workforce wellbeing provision. Qualitative semi-structured interviews were undertaken with twenty-four (20F, 4M) employees from an acute hospital trust in the UK. Interviews were digitally recorded and transcribed, data were handled and analysed using thematic analysis. Interviews generated 3 over-arching themes, and 13 sub-themes covering ‘exposure and job roles’, ‘emotional impacts of COVID-19 and ‘the wellbeing centres’. Supported wellbeing centres were viewed as critical for the wellbeing of hospital employees during the first surge of COVID-19 in the UK. Wellbeing initiatives require managerial advocacy and must be inclusive. Job-related barriers to work breaks and accessing staff wellbeing provisions should be addressed. High quality rest spaces and access to peer-to-peer support are seen to benefit individuals, teams, organisations and care quality. Training NHS staff in psychological first aid is a useful approach to supporting the wellbeing of the NHS workforce during and beyond the COVID-19 pandemic.
Oncogenic Role of miRNA by Environmental Exposure to Plasticizers: A Systematic Review.
Authors: Ferrante Margherita , Cristaldi Antonio , Oliveri Conti Gea
Published: April 2021

The environmental exposure of human in the daily and occupational activities to plasticizers may adversely affect human health, and thus represents a global issue. The altered expression of MicroRNAs (miRNAs) exerts an important pathogenic role linked also to the exposure to plasticizers. This systematic review summarizes the recent findings showing modified ex-pression of miRNAs in cancer due to plasticizers exposures. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the past ten years, focusing on the relationship between plasticizer exposures and expression of miRNAs cancer. Starting by 535 records, 17 articles were included. Results support the hypothesis that exposure to plasticizers cause changes or deregulation of a number of oncogenic miRNAs and showed that plasticizers interaction with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22; miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolisms that participate in many overlapped cellular processes, and miRNA level changes can be a useful tool for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers
Hydrodechlorination of CHClF2 (HCFC-22) over Pd-Pt catalysts supported on thermally modified activated carbon. Beneficial effect of catalyst oxidation.
Authors: Radlik Monika , Juszczyk Wojciech , Raróg-Pilecka Wioletta , Zybert Magdalena , Karpiński Zbigniew
Published: April 2021

Pd-Pt catalysts supported on carbon preheated to 1600°C have been reinvestigated in CHFCl2 hydrodechlorination. An additionally adopted catalyst oxidation at 350-400°C produced an order of magnitude increase in the catalytic activity of Pd/C. This increase is not caused by changes in metal dispersion or possible decontamination of the Pd surface from superficial carbon, but rather by unlocking the active surface, originally inaccessible in metal particles tightly packed in the pores of carbon. Burning carbon from the pore walls attached to the metal changes the pore structure, providing easier access for the reactants to the entire palladium surface. As upon calcination the performance of the rest of the Pd-Pt/C catalysts changes less than for Pd/C, the relation between the turnover frequency and alloy composition does not confirm the Pd-Pt synergy invoked in our previous work. The use of even higher-preheated carbon (1800°C), completely free of micropores, results in a Pd/C catalyst that does not need to be oxidized to achieve high activity and excellent selectivity up to CH2F2 (>90%).
Impact of Partial lockdown on Time-Dependent Effective Reproduction Number of COVID-19 infection in Ghana: Application of change point analysis
Authors: Armachie Joseph , Adom-Konadu Agnes , Asiamah Morrison , Dwomoh Duah
Published: April 2021

In 2020, the world was plagued with COVID-19 which was first identified in Wuhan, China in November 2019. During the early phase of the pandemic with no known treatment and WHO-approved vaccines, most government and public health officials were pushing for non-pharmaceutical intervention in trying to curb the spread of COVID-19. One such intervention is the restriction on movement to reduce social mixing. However, the economic cost of locking down cities especially in developing countries is unbearable as most of these countries are running economies that were on life support before the COVID-19 pandemic. We analyze the daily COVID-19 cases in Ghana to evaluate whether there was a significant change in transmission of COVID-19 after the partial lockdown of the two main cities (Kumasi and Accra) was lifted. The results showed that there was no increase in the transmissibility of COVID-19 after the partial lockdown was lifted. Contrary to the expectation that transmissibility will increase after lifting the partial lockdown, there was a reduction of the time-dependent reproduction ratio from 3.17 to 1.23.
The Role of Nurses in Providing Social Support in Tuberculosis Treatment: Literature Review
Authors: Elfiyunai Ni Nyoman , Glorino Rumambo Pandin Moses
Published: April 2021

Background Tuberculosis is a type of infectious disease that can cause death if treatment is not completed. the duration of tuberculosis treatment can reach 6 to 8 months so it really requires discipline when doing treatment. This makes tuberculosis patients in dire need of health information and social support which is very helpful in providing motivation, health information, and monitoring treatment from nurses. Aim of this literature review is to provide an overview of the The Role Of Nurses In Providing Social Support In Tuberculosis Treatment: Literature Review. Method is a literature review research, this study uses electronic database searches using keywords according to research questions from the online library PubMed, Content Science, and Science Direct. Result it was found that the role of nurses in the aspect of social support, namely in providing motivation, supervision, comfort, empathy, and information. this is very necessary for patients with tuberculosis at the time of treatment. Conclution social support is needed by tuberculosis patients who are currently undergoing treatment to provide motivation, health information, and as a nurse's supervision of patient adherence to tuberculosis treatment.
Evaluation of the Role of Nursing Institutions in the Implementation of Patient Safety by Nursing Students in 21st Century: Literature Review
Authors: Puspita Sari Dyah Wiji , Rumambo Pandin Moses Glorino
Published: April 2021

Students' knowledge of the concept of patient safety in infection prevention and control and treatment safety is still low. Real-life problem-based learning approaches in the area of ​​clinical education assist in patient safety education. This study was designed to identify, evaluate and summarize available evidence on the effectiveness of clinical education on student achievement of patient safety competencies. The Methode that use in this study is systematic review. Search for articles in research journals obtained from Sciencedirect, Ebscohost, Garuda, Proquest and Scopus. As many as 228 articles were obtained consisting of nursing journals and health journals with the keywords clinical education, competence, and patient safety. After that, the screening process was carried out based on the inclusion criteria and obtained 25 articles that met the criteria. The result of this study are the contribution of educational institutions in the achievement of patient safety competencies for nursing students is still low and the achievement of patient safety competencies for students at the professional level is better than for students who are still learning theory in educational institutions. The conclusion of this study is clinical education carried out by educational institutions is considered ineffective in achieving the competence of patient safety for nursing students. Therefore, it is necessary to develop a patient safety model or curriculum that is attached to clinical education in nursing education institutions
Comparison of Forecasting Ability for Energy Consumption in BRICS: ARIMA (1,1,1) and FGM (1, 1) Models
Authors: Khan Atif Maqbool , Osinska Magdalena
Published: April 2021

Brazil, Russia, China, India, and the Republic of South Africa (BRICS) represent developing economies facing different energy and economic development challenges. The current study aims to forecast energy consumption in BRICS at aggregate and disaggregate levels using the annual time series data set from 1992 to 2019 and to compare results obtained from a set of models. The time-series data are from the British Petroleum (BP-2019) Statistical Review of World Energy. The forecasting methodology bases on a novel Fractional-order Grey Model (FGM) with different order parameters. This study contributes to the literature by comparing the forecasting accuracy and the forecasting ability of the FGM(1,1) with traditional ones, like standard GM(1,1) and ARIMA(1,1,1) models. Also, it illustrates the view of BRICS's nexus of energy consumption at aggregate and disaggregates levels using the latest available data set, which will provide a reliable and broader perspective. The Diebold-Mariano test results confirmed the equal predictive ability of FGM(1,1) for a specific range of order parameters and the ARIMA(1,1,1) model and the usefulness of both approaches for energy consumption efficient forecasting.
The Factors Affecting Labour Productivity in the Construction of Prestressed Concrete Buildings in Ghana
Authors: Akbar Muhammad , Darkwah Kojo Kumah , Amin Azka , Huali Pan , Guoqiang Ou , Asghar Muhammad
Published: April 2021

The construction industries face several challenges related to productivity. Productivity mainly depends upon labour effort and performance. The poor productivity of labour is one of the major reasons of time over-runs and increasing cost in construction projects. Our study aims to build a comprehensive assessment on the relationship between various factors that affect labour productivity in the construction of prestressed concrete Buildings in Ghana. A sample of 200 re-spondents collected from workers of Construction Company in Ghana. The questionnaire was designed which comprises two parts; the first part contains background information of the staff of construction company while second section explores the opinion of the staff regarding factors af-fecting labour productivity. The Smart-PLS was utilized to analyze and estimate the relationship among construct variables. By utilizing relative importance index and multiple linear regressions, it is identified that the management factor such as inadequate incentives; material factor such as poor quality of material; labour factors such as poor quality and training of labors; supervision factor such as incompetence of site supervisor; equipment factor such as frequent damage of equipment have a negative and significant relationship with labour productivity in the construc-tion of prestressed concrete buildings in Ghana. The findings of this study recommend that in order to improve labour productivity, the construction industries must conduct labour productivity measurements by adopting schedule for procurement of materials, safety programs, motivational system, and frequent meeting with project professionals.
Development of a High Throughput Method to Study the Inhibitory Effect of Phytochemicals on Trimethylamine Formation
Authors: Iglesias-Carres Lisard , Essenmacher Lauren A. , Racine Kathryn C. , Neilson Andrew P.
Published: April 2021

Choline is metabolized by the gut microbiota into trimethylamine (TMA), the precursor of pro-atherosclerotic molecule trimethylamine N-oxide (TMAO). Reduction of TMA formation has been shown to provide to cardioprotective effects, and some phytochemicals may produce such reduction. This study aimed to develop an optimized, high-throughput anaerobic fermentation methodology to study inhibition of choline microbial metabolism into TMA by phenolic compounds with healthy human fecal starter. Optimal fermentation conditions were: 20 % fecal slurry (1:10 in PBS), 100 M choline, and 12 h fermentation. Also, 10 mM of 3,3-dimethyl-1-butanol (DMB) was defined as a positive TMA production inhibitor, achieving a ~50 % reduction in TMA production. Gallic acid and chlorogenic acid reported higher TMA inhibitory potential (maximum of 80 -90 % in. TMA production inhibition), with IC50 around 5 mM. Nor DMB neither gallic acid and chlorogenic acid reduced TMA production through cytotoxic effects, indicating mechanisms such as altered TMA lyase activity or expression.
Efficiency Management in Catch Handling Onboard Small Boats - Standardisation of Processes in Icelandic Fisheries
Authors: Karlsdóttir Ingibjörg , Cook David , Minelgaite Inga
Published: April 2021

Small boat fishers are often the lifeblood of remote coastal communities in Iceland, contributing to employment, jobs and economic prosperity. This study conducts exploratory but highly practical research into the efficiency of onboard catch handling practices by Icelandic small boat fishers using fish handling tools called automatic jigging machines. Using applied research methods, this study researches whether standardisation of operations could be applied to make catch handling practices on small boats more time and resource efficient, leading to reduced waste, a consistently higher quality product, and potential increases in economic efficiency and sustainability. Thematic analysis, value stream mapping, flow analysis and Kaizen ideology were adopted to identify gaps and continuous improvement opportunities to standardise processes, leading to exemplary performance. Eight core recommendations are identified, seven of which are classed as straight-forward, ‘do now’ measures according to a Kaizen Priority Matrix. These include human and technological interventions in the areas of safety, organisational arrangements, hygiene, fish handling and bleeding, and cooling. Questionnaire responses reveal four main themes of importance to the sub-sector: changes in recent decades; the importance of small boat fishers; education and improvement; and the particularities of the sub-industry. The latter include the perception of a ‘race against time’ to land the catch, an issue that sometimes contributes to sub-optimal catch handling practices. Although this study has decidedly practical connotations for small boat fishers, its outcomes are also likely to be of interest to academics, particularly those focused on the organisational management of natural resources and general applications of the project management methodology and applied research methods as a means of solving practical problems in everyday life.
ANALYSIS OF THE ORNAMENTAL FISH EXPORTS FROM THE AMAZON STATE, BRAZIL
Authors: TRIBUZY-NETO Ivan Azevedo , BELTRÃO Hélio , BENZAKEN Zehev Schwartz , YAMAMOTO Kedma Cristine
Published: April 2021

The updated status of the ornamental fish trade from the Amazonas state was analyzed between the years of 2006-2015 (IBAMA database). The trade of ornamental fish from Amazonas state mainly consists of species extracted from nature. A total of 142,552,253 specimens were exported during the studied period. Sales plummeted since 2006, from 26,075,241 specimens exported then to 2,729,846 specimens in 2015 (Jan-Jul). Between 2006 and 2015, a total of US$ 23.0 million in revenue was generated from fish exports destined to 35 countries. Germany, Taiwan, USA and Japan accounted for 75.5% of the volume and 76.7% of the value exported. During this time, 375 species were exported, included Paracheirodon axelrodi, P. simulans, Hemigrammus bleheri, Otociclus affinis and O. hoppei that together represented 84.5% of exports. Thirty are not on the list of IBAMA species released for export, and six are currently on the list of endangered fauna of Brazil, being them: Hopliancistrus tricornis, Leporacanthicus joselimai, Parancistrus nudiventris, Peckoltia compta, Scobinancistrus auratus and S. pariolispos. These results are an additional tool for managers, environmentalists and decision makers to establish regulations to govern the trade.
OPTIMALISASI PROSES CARGODORING PADA TERMINAL PETI KEMAS BANJARMASIN
Authors: Ladesi Vivian Karim , Ridho Salman
Published: April 2021

Transportasi merupakan moda sebagai means bagi manusia atau individu untuk mencapai tujuan, satu titik menuju satu titik tujuan lainnya. Indonesia merupakan negara kepulauan maka transportasi bermain peran penting bagi kelangsungan hidup serta bermasyarakat, berbangsa, dan bernegara. Pelabuhan yang baik menurut Undang Undang kepelabuhanan nomor 17, tahun 2008, dilengkapi dengan fasilitas keselamatan pelayaran dan kegiatan penunjang pelabuhan serta sebagai tempat perpindahan intra dan antar moda transportasi. Kegiatan pada pelabuhan berupa perpindahan kargo Cargodoring, yaitu proses pergerakan barang dari gudang atau lapangan penumpukan ke dermaga atau apron yang di bawa oleh alat bantu angkut. Pengamatan hanya mencakup beberapa aspek salah satunya pada Waktu putar head truck yang lama selama proses cargodoring. Terminal Peti kemas Banjarmasin, PT Pelindo III Persero, cabang Kalimantan Selatan, dapat ditemukan permasalahan lambatnya turn-around-time head truck atau kegiatan cargodoring yang mengakibatkan keterlambatan pada waktu keberangkatan atau departure kapal. Untuk mengetahui berapa lama waktu yang dibutuhkan head truck untuk melakukan cargodoring. Penuilis melakukan Pengamatan langsung secara terlibat. Dengan melakukan perbaikan pada lintasan didalam pelabuhan untuk dapat mendukung peningkatan kecepatan pada chassis dan juga gerak pada alat angkat pada lapangan penumpukan atau container yard, yang dapat menghasilkan produktivitas yang lebih baik pada kegiatan bongkar dan muat.