bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase 1/2 study of detalimogene voraplasmid (EG-70) intravesical monotherapy for patients with high-risk non-muscle invasive bladder cancer (NMIBC).
Authors: Joshi Shreyas , Chang Sam S. , Dickstein Rian J. , Jayram Gautam , Shore Neal D. , Liu Jen-Jane , Lotan Yair , Satkunasivam Raj , Schuckman Anne K. , Steinberg Gary D. , Taylor John R. , Linback Tammy , Pruthi Raj , Sullivan James C. , Tosone Christine , Kamat Ashish M.
Published: February 2025

TPS886

Background:
High-risk NMIBC is generally treated with adjuvant intravesical bacille Calmette-Guérin (BCG); however, ~50% of patients experience recurrence and/or progression after BCG and are considered unresponsive. Detalimogene voraplasmid (EG-70) is an investigational, intravesically administered therapy designed to elicit local stimulation of anti-tumor immune responses in the bladder and drive durable efficacy in BCG-unresponsive NMIBC, while mitigating the risk of systemic toxicities from immune stimulation. The Phase 1 (dose-escalation) portion of the first-in-human Phase 1/2, open-label, multicenter study (LEGEND; NCT04752722) of detalimogene voraplasmid is complete. The Phase 2 dose was identified, treatment was generally well tolerated, and the overall complete response (CR) rate was 73% [Kalota S, et al. AUA 2024]. Here we describe the ongoing Phase 2 portion of the study, which opened to enrollment in May 2023; a new cohort of papillary only (no carcinoma
in situ
[CIS]) disease is being included.
Methods:
Eligibility criteria: age ≥18 years; ECOG PS 0−2; NMIBC, with/without resected coexisting papillary tumors, ineligible for, or elected not to undergo, cystectomy; satisfactory bladder function. Patients receive detalimogene voraplasmid 0.8 mg/mL in 50 mL (intravesical administration, Weeks 1, 2, 5 & 6, 12-week cycle) for 4 cycles: BCG-unresponsive with CIS (Cohort 1); BCG-exposed or BCG-naïve with CIS (Cohort 2); BCG-unresponsive with high-grade papillary bladder cancer without CIS (Cohort 3). Phase 2 primary endpoints: efficacy (CR rate at Week 48); safety. Secondary endpoints: progression-free survival; CR rate at Weeks 12, 24, 36, and 48; duration of response. The study is being conducted in accordance with the ethical principles of the Declaration of Helsinki and is consistent with ICH/GCP. All patients provide written informed consent. The Phase 2 portion of the study is enrolling and will recruit up to 300 patients from sites in the USA, Canada, Europe, and the Asia-Pacific region. Clinical trial information:
NCT04752722
.
A clinical trial evaluating the efficacy and safety of disitamab vedotin plus tislelizumab combined with re-TURBT in the treatment of HER-2-high expression (2+-3+) non-muscle invasive bladder cancer at high-risk and very high-risk.
Authors: Chen Jianhui , Su Yiming , Liu Rong , Chen Ru , Zhu Shaoxing , Qiu Qianyi
Published: February 2025

TPS895

Background:
Current studies indicate that the combination of Disitamab Vedotin and PD-1 inhibitors can enhance the efficacy of systemic therapy in patients with HER2-positive urothelial carcinoma, with an acceptable safety profile. However, the evidence supporting its use in high-risk and very high-risk NMIBC remains limited. And several clinical guidelines recommend a re-TURBT for high-risk NMIBC patients, as it has been shown to significantly reduce the 5-year recurrence and progression rates.Therefore, this study aims to evaluate the efficacy and safety of the triplet regimen of Disitamab Vedotin, Tislelizumab (a PD-1 inhibitor), and re-TURBT in patients with HER2 IHC 2+ or 3+ high-risk and very high-risk NMIBC.
Methods:
Patients diagnosed with high-risk and very high-risk NMIBC, based on medical history, clinical presentation, imaging examinations (such as MRI with plain and enhanced scanning), and transurethral resection for tissue pathological biopsy, are included in the "case screening process".After excluding surgical contraindications, TURBT is performed; postoperative tissue pathological examination confirms NMIBC, and patients with immunohistochemical results of HER2 as 3+ or 2+ enter further screening. Referring to the AUA guidelines, high-risk and very high-risk NMIBC are included in subsequent analysis, where those who meet the inclusion criteria of this study, excluding the exclusion criteria, and who have recovered well after the initial TURBt and are assessed to be able to complete a second TURBT within six weeks are considered as the final candidates for enrollment.Eligible patients for single-arm enrollment (N=40) will receive Tislelizumab (200mg) + Disitamab Vedotin (120mg for weight ≤60Kg or 2.0mg/Kg for weight ≥60Kg) the day after the initial TURBT, to be repeated every 3 weeks (Q3W). Patients are also scheduled to undergo a second TURBT within 6 weeks, and after the surgery, they will continue with three more courses of Tislelizumab + Disitamab Vedotin (Q3W) until the end of the 3-year follow-up period. The primary endpoint for evaluation in this study phase is the 1-year event-free survival rate (EFS),which is defined as the possibility of patients have not experienced any events for at least 12 months after receiving treatment, including death, disease progression, switch to chemotherapy, addition of other treatments, fatal or intolerable side effects, etc. Clinical trial information:
NCT06630871
.
A phase 2 trial of neoadjuvant futibatinib plus durvalumab for cisplatin-ineligible patients with
FGFR
overexpressing muscle-invasive bladder cancer.
Authors: Yang Yuanquan , Jain Rohit K. , Gupta Shilpa , Tsung Irene , Gopalakrishnan Dharmesh , Gheeya Jinesh S. , Wei Lai , Satturwar Swati , Parwani Anil , Collier Katharine A. , Pohar Kamal S. , Sundi Debasish , Lee Cheryl T. , Li Zihai , Roychowdhury Sameek , Mortazavi Amir
Published: February 2025

TPS899

Background:
There is an unmet need to develop neoadjuvant therapies for cisplatin-ineligible patients (pts) with muscle-invasive bladder cancer (MIBC). Neoadjuvant immune checkpoint inhibition (ICI) has shown promising early results in this population; however, > 2/3 pts did not achieve pathological complete response (pCR), a surrogate endpoint for improved survival. Fibroblast growth factor receptor inhibitor (FGFRi) may induce synergy with ICI through modulation of the tumor immune microenvironment.
FGFR
mRNA overexpression by RNA in situ hybridization (ISH) is an emerging biomarker that may predict responses to an FGFRi ± ICI. Futibatinib (FUTI) is an irreversible pan-FGFRi, and durvalumab (DURV) is an anti-PD-L1 antibody.
Methods:
This is a phase 2, single arm, multicenter study to evaluate the efficacy and safety of neoadjuvant FUTI + DURV before cystectomy. Pts with stage cT2 to cT4aN0M0, urothelial carcinoma predominant histology, cisplatin-ineligible by Galsky criteria, and
FGFR1-3
mRNA expression ≥3+ by RNAscope ISH assay are eligible. Twenty-four pts will be treated with FUTI 20 mg PO daily and DURV 1500 mg IV on day 1 of every 28-day cycle for 3 cycles. The primary outcome is pCR (defined as ypT0N0). We hypothesize that FUTI + DURV will improve the pCR rate from 21% to 41%. This trial has 80% power to detect the alternative hypothesis while maintaining a one-sided α = 0.1. The study will begin with a safety lead-in period, during which 6 pts will be enrolled for dose-limiting toxicity (DLT) evaluations. After confirming safety (≤ 2 DLTs), another 18 pts will be enrolled. The study will be monitored for futility using a Bayesian Optimal Phase II design, including 2 interim analyses (12 and 18 pts). If there are ≥ 3 pCRs among the first 12 pts, we will continue enrollment. If there are ≥ 5 pCRs among the first 18 pts, the study will continue. When 24 evaluable pts are enrolled, we will reject the null hypothesis and conclude that the treatment is acceptable if there are ≥ 8 pCRs. The secondary endpoints include safety, pathologic downstaging rate, progression-free survival, and overall survival. Correlative studies will explore immune and molecular predictors of response and resistance in the tumor, blood, and urine. Clinical trial information:
NCT06263153
.
Subtyping of Primary Aldosteronism by Adrenal Venous Sampling
Authors: Rossi Gian Paolo , Battistel Michele , Seccia Teresa Maria , Rossi Federico Bernardo , Rossitto Giacomo
Published: February 2025

Primary aldosteronism (PA), the most common cause of arterial hypertension, is surgically curable if a unilateral source of the hyperaldosteronism is discovered. To identify the patients who are curable, all current guidelines recommend adrenal venous sampling (AVS), a procedure which, albeit simple in principle, remains scarcely available and markedly under-utilized, because it is still perceived as technically challenging, invasive, and difficult to interpret. The lack of uniformly accepted standards for performance and interpretation of AVS, alongside the diffuse concerns that, albeit quite rarely, it can be complicated by adrenal vein rupture, contribute to the scant utilization of AVS.

In the last decade, several major studies have contributed to a greater understanding of the use of AVS in PA patients, thus paving the way to a more rational and effective application that can allow to diagnose many more PA patients with a unilateral form of the disease to be referred for curative adrenalectomy. Moreover, microcatheters and androstenedione have been introduced to increase the success rate. This review provides updated information on the subtyping of PA by means of AVS and examines key issues on the selection and preparation of patients, the optimal performance of the procedure, and the interpretation of its results for diagnostic purposes, even in the most challenging cases. Situations when AVS can be omitted before surgery and alternative functional imaging techniques that have been proposed to identify unilateral surgical curable PA to circumvent the bottle-neck represented by the limited availability of AVS world-wide, are also discussed.
Effect of Painful Stimuli on PVNCRH Neurons: Implications for States of Consciousness Under Isoflurane Anesthesia
Authors: Yu Le , Zhu Xiaona , Duan Wenying , Yang Kexin , Hu Ji , Zhang Ye
Published: February 2025

BACKGROUND:

Many patients undergoing surgery experience accompanying pain symptoms preoperatively. The impact of painful stimuli on general anesthesia remains largely unknown. Corticotrophin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (PVNCRH neurons) are crucial central stress hubs that respond to painful stimuli. These neurons also participate in regulating processes such as sleep and anesthesia. Natural reward can inhibit PVNCRH neurons to relieve stress-induced behavioral changes, but the effect of natural reward on the anesthesia process in patients with pain is not clear. In this study, we assessed the impact of painful stimuli on isoflurane anesthesia and its potential neural mechanism. We also investigated the potential of natural reward therapy for alleviating the impact of painful stimuli on isoflurane anesthesia.

METHODS:

The righting reflex test and cortical electroencephalography (EEG) were used as measures of consciousness in complete Freund’s adjuvant (CFA)-injected mice during isoflurane anesthesia. EEG and burst-suppression ratios (BSR) were used to assess the depth of anesthesia. The expression of c-Fos, fiber photometry recording, and brain slice electrophysiology were used to determine neuronal activity changes in PVNCRH neurons after CFA injection or 10% sucrose treatment. Finally, chemogenetic technology was used to specifically manipulate PVNCRH neurons.

RESULTS:

Compared to the saline-injected mice, the CFA-injected mice exhibited an increased the mean[SD] induction time of isoflurane anesthesia (354[48] s vs 258[30] s, P = .0001) and a reduced BSR of isoflurane anesthesia (60.1[10.3] % vs 81.5[9.76] %, P = .002). CFA injection increased PVN c-Fos expression (3667[706] vs 1735[407], P = .0002) and enhanced the population activity of PVNCRH neurons (33.4[13.6] % vs 1.23[3.57] %, P = .0009). Chemogenetic suppression of PVNCRH neurons reversed the anesthesia abnormalities in CFA-injected mice. Natural reward accelerated the induction time of isoflurane anesthesia (252[24] s vs 324[36] s, P = .003) and increased the BSR of isoflurane anesthesia (84.8[5.36] % vs 57.7[14.3] %, P = .0005). Chemogenetic activation of PVNCRH neurons reversed the effect of natural reward on isoflurane anesthesia in CFA-injected mice.

CONCLUSIONS:

Painful stimuli affect the process of isoflurane anesthesia by activating PVNCRH neurons, which implies that these neurons modulate isoflurane anesthesia. Additionally, natural reward alleviates the impact of painful stimuli on isoflurane anesthesia by inhibiting PVNCRH neurons.
Public Policy as Trans Harm
Authors: Sharrow Elizabeth
Published: February 2025

The observation that systems of state governance are more apt to do harm or violence to transgender and gender-diverse people is foundational to the field of trans studies. This article argues that public policy—including policy design, implementation, governance, and administration—is an important target for transfeminist sports studies. It illustrates the importance of attending to Title IX of the Education Amendments of 1972, a federal sex nondiscrimination policy in the United States. This case underscores how public policy through its widespread enactment in American school-sponsored sports and overreliance on binary logics of sex-segregated categories remains paramount, though underanalyzed, as a vehicle for trans harm.
Creating a Non–Gender Binary Sports Space
Authors: Yang Jinsun
Published: February 2025

Trans inclusion policies remain one of the major issues facing contemporary trans rights movements in the United States. In sports, where sex segregation has rarely been challenged, trans inclusionary policies have emerged as a public debate in which key values of liberal individualism such as fairness, meritocracy, and safety collide with trans athletes' rights to belong in a public arena. While queer feminists' scholarship on sports has criticized the notion that trans inclusion policies do not necessarily problematize a binary gender ideology and sports institutions' authority in policing athletes' bodies, few studies have investigated alternative sports spaces and policies to challenge the sexist culture and binary sex-based structure of mainstream sports. This article introduces the Queer Women Games, a non–gender binary sports competition in Korea, as an experimental site to imagine and implement gender justice in sports through organizational actions and collective involvement. First, the author compares the QWG's nonbinary policies with transgender inclusion policies in recreational sports in terms of their approaches to sex segregation, sports authorities governing athletes' genders, and transgender exclusion. Then the author argues that the nonbinary policy opened a dialogue, which seems to be foreclosed in inclusion-based approaches, by undoing sex segregation and building a consensus on rejecting gender policing.
Queer African Feminist Orientations for a Trans Sports Studies
Authors: Adjepong Anima
Published: February 2025

This commentary makes a case for developing trans sports studies out of queer African feminism. Queer African feminism is an epistemological orientation that affirms a flexible gender system, despite contemporary colonial gender ideologies, which insist on biological dimorphism. Queer African feminism offers to sports studies an analytical framework that attends to how colonialism, patriarchy, religion, and capitalism structure gender and sexual ideologies within sport and offers meaningful opportunities for disrupting these unjust systems. By centering the experiences of African athletes deemed intersex by sporting and medical authorities, the author demonstrates how current approaches to undermining sex segregation in sports still risk excluding certain athletes—intersex, nonbinary, and non-medically transitioning athletes. Ultimately, the author argues that if the goal of trans sports studies is to help bring about gender justice in sports, queer African feminism can offer a generative framework for attaining this goal.
The MBB Manifesto
Authors: Martins Raphael H. , Vieira Pedro , Snyder Cara
Published: February 2025

The Meninos Bons de Bola (MBB, or Soccer Star Boys) is Brazil's first trans soccer team. We are a collective that welcomes transgender men, transmasculine people, trans women, and travesti players. Our manifesto recognizes that the fight for trans inclusion in athletics is part of a larger struggle against repression and fascism, and as such, we demand full access to sport for people of any and all genders and sexual orientations.
Training on a 3D-Printed Simulation Model Improves Accuracy in External Ventricular Drain Placement
Authors: Kosterhon Michael , Turgut Merih Ö. , Gielisch Matthias , Graef Julian , Ringel Florian
Published: February 2025

BACKGROUND AND OBJECTIVES:

External ventricular drain (EVD) placement is a critical, lifesaving procedure in cranial neurosurgery, often performed manually using anatomical landmarks that vary between individuals. This study evaluates the efficacy of a 3-dimensional (3D)–printed EVD training model designed to improve the accuracy of this procedure.

METHODS:

Computed tomography scans from 3 patients were used to create 3D-printed head models with narrow, wide, and normal ventricles. Twenty-five neurosurgeons participated in a three-round training protocol: pre-training, training with neuronavigation and a standardized protocol, and post-training. The accuracy of EVD placement was measured using an optical navigation system, and participants' confidence levels were assessed through questionnaires.

RESULTS:

Training significantly enhanced EVD placement accuracy. Pre-training, only 55.3% of placements were intraventricular (Kakarla grade 1), which increased to 84.0% post-training (P < .001). The distance to the ideal entry point improved from 5.8 mm (SD, ±3.7 mm) to 4.1 mm (SD, ±1.5 mm), and the distance to the target point improved from 12.6 mm (SD, ±5.8 mm) to 8.3 mm (SD, ±4.0 mm) (P < .001 for both). The time to identify entry points and puncture the ventricles also improved significantly. Left-sided EVDs were more frequently misplaced. In addition, right-handed participants (n = 24) performed better when placing left-sided EVDs with their right hand. Participants with more than 6 years of experience were more likely to misplace the EVD and overestimate their placement accuracy compared with less experienced participants. Post-training, both experienced and less experienced neurosurgeons achieved similar success rates. Confidence in EVD placement and puncture direction significantly increased post-training.

CONCLUSION:

A standardized training protocol using a 3D-printed model significantly improves the accuracy and confidence of neurosurgeons in EVD placement. Regular training is recommended to maintain high clinical performance, emphasizing the need for standardized procedures and the use of neuronavigation for complex cases.
Cancer biomarkers for immune and targeted therapy
Authors: Μουτάφη Μυρτώ
Published: February 2025

Σκοπός Η ανάλυση βιοδεικτών στον καρκίνο δεν παρέχει μόνο πρόσθετες πληροφορίες σχετικά με τους κλασσικούς κλινικούς παράγοντες, αλλά επιτρέπει επίσης σε ασθενείς με πιο ευνοϊκή σχέση οφέλους-κινδύνου να λάβουν συγκεκριμένες θεραπείες. Σε αυτή τη μελέτη βιοδεικτών επικεντρωθήκαμε σε δύο επιθηλιακούς καρκίνους, τον Ακανθοκυτταρικό Καρκίνο Κεφαλής και Τραχήλου (ΑΚΚΤ) και τον Καρκίνο του Μαστού (ΚΜ). Μέθοδοι και Ασθενείς Δείγματα από σαράντα έναν ασθενείς με ΑΚΚΤ που τυχαιοποιήθηκαν σε Cisplatin συν Olaparib (Σκέλος Α), μόνο Olaparib (Σκέλος Β), χωρίς θεραπεία (Σκέλος Γ) ή Durvalumab συν Olaparib (Σκέλος Δ) χρησιμοποιήθηκαν για την αξιολόγηση προκαθορισμένων βιοδεικτών.Κυτταρικές σειρές και μικροσυστοιχίες ιστών (tumor microarrays, ΤΜΑ) χρησιμοποιήθηκαν για να εξεταστεί το δυναμικό εύρος του βιοδείκτη HER2 και να αναπτυχθεί μια δοκιμασία ειδική για την χαμηλή έκφραση HER2 και στη συνέχεια να προσδιοριστεί η επικράτηση της χαμηλής έκφρασης σε κάθε δείγμα από μια σειριακή, αναδρομική συλλογή περιπτώσεων καρκίνου του μαστού. Αποτελέσματα Μείωση του Ki67 κατά τουλάχιστον 25% παρατηρήθηκε στο 44,8% των θεραπευμένων ασθενών, όπως μετρήθηκε με ανοσοφθορισμό (QIF). Τα επίπεδα PD-L1 ήταν σημαντικά υψηλότερα μετά τη θεραπεία στα σκέλη (Α) και (Δ). Η έκφραση των γονιδίων CD163 και Colony Stimulating Factor 1 Receptor (CSF1R), δεικτών των Μ2 μακροφάγων, αυξήθηκε σημαντικά μετά τη θεραπεία, ενώ η έκφραση του CD80, ενός δείκτη των Μ1 μακροφάγων, μειώθηκε. Με τον υπολογισμό των ορίων ανίχνευσης, ποσοτικοποίησης και γραμμικότητας της δοκιμασίας HER2, προσδιορίσαμε ότι η έκφραση του HER2 σε χαμηλό εύρος σε μη ενισχυμένες κυτταρικές σειρές βρίσκεται μεταξύ 2 και 20 αττόμολ/mm2. Συμπέρασμα Η θεραπεία με βάση το Olaparib τροποποιεί το μικροπεριβάλλον του όγκου οδηγώντας σε υπερέκφραση του PD-L1 και στην επαγωγή προ-ογκογόνων χαρακτηριστικών των μακροφάγων. Η εφαρμογή αυτής της δοκιμασίας σε μια σειριακή συλλογή 364 περιπτώσεων καρκίνου του μαστού από το Yale δείχνει ότι το 67% του πληθυσμού έχει έκφραση HER2 πάνω από το όριο ποσοτικοποίησης και κάτω από τα επίπεδα που παρατηρούνται στον καρκίνο του μαστού με ενίσχυση HER2.
Development of the Theory and Practice of Monitoring the Sustainable Development (of the Pharmaceutical Industry)
Authors: Balihin M.
Published: February 2025

The article summarizes theoretical aspects, specifies the features and results of sustainable development of the modern pharmaceutical industry in Russia. Key areas, tasks and stages of monitoring the sustainable development of the industry in the context of its modernization are highlighted. Directions for expanding the information and methodological base in the digital environment are determined to improve the quality of monitoring the sustainable development of the industry and provide information to interested users.
Accounting Support FOF Investment Valuation of Public High-Growth Companies in Russia
Authors: Voronova E. , Lukina Yu.
Published: February 2025

The article is devoted to improving the accounting support for assessing the investment attractiveness of public high-growth companies operating in the Russian market. The article provides the author’s definition of the concept of high-growth companies, and identifies the features of this group of companies that determine the specifics of assessing their investment attractiveness. The authors offer recommendations for presenting information on the value of the company’s assets in the balance sheet as a tool for increasing investment attractiveness. A matrix for disclosing information on the revenue of high-growth companies by segments of activity is presented and applied to PJSC Yandex. An improved income statement for high-growth companies which has informational and analytical value for potential investors is proposed. The necessity for additional disclosures in reporting to ensure information transparency is noted, and the need for audits to be conducted by companies with a positive reputation in the market is substantiated.
Perception of Risk in the Context of sex Work among Venezuelan Immigrant Women and Men in Colombia
Authors: Restrepo Pineda Jair Eduardo , Villegas Rojas Soraya , Aguirre Ocampo Dannys Alberth
Published: February 2025

The objective was to analyze the perception of risk among cisgender and transgender Venezuelan immigrant men and women who offer sexual services in Colombia, with the purpose of identifying the factors that intervene in the ability to detect, identify and react to a situation of potential harm in the context of transactional sex. Qualitative research was developed with an interpretative hermeneutic approach and semi-structured interviews were used as a research technique. A total of 55 sex workers were interviewed in Bogotá D.C., the Metropolitan Area of the Aburrá Valley and the Colombian coffee-growing region, 69% of whom were male at birth and 31% were female. Regarding gender identity, 60% self-identified as cisgender men, 31% as cisgender women, and the remaining 9% as transgender women. The average age of the participants was 27 years old. Regarding immigration status, 69% of the sex workers interviewed were in the country illegally. Three types of risk were identified, namely biological, psychological and social, which are related to each other, generating situations of vulnerability in sex workers. In addition, the need for an analysis with an intersectional approach that takes into account the factors that increase the vulnerability of sex workers to HIV, sexually transmitted infections (STI), violence and gender-based violence, such as sexual orientation, gender identity, age, migratory status, among others, became evident.
Educação para a menopausa: Abordagens intersetoriais, rodas de conversas e práticas corporais para mulheres na transição da menopausa
Authors: Vasconcelos Liliane Ribeiro , Bonfante Ivan Luiz Padilha , Ramkrapes Ana Paula Boito , Cavaglieri Cláudia Regina
Published: February 2025

Introdução: A menopausa é um evento natural da vida feminina, que marca o fim do período reprodutivo. É marcada por sintomas físicos e psicológicos, ocasionados pela parada de produção dos hormônios ovarianos, o que pode causar problemas relacionados à saúde e à qualidade de vida. A prática de atividades físicas têm sido uma ferramenta importante na Atenção Básica à Saúde para minimizar os efeitos desse período. No entanto, diversas barreiras como fatores sociais, emocionais, falta de infraestrutura e segurança limitam o acesso dessas mulheres a uma vida regularmente ativa. Adicionalmente, ainda faltam informações e conhecimento sobre este período e de como as atividades físicas podem influenciar beneficamente essa etapa da vida das mulheres. Objetivo: Propor um modelo de intervenção educacional, focado na disseminação de informações sobre a menopausa, por meio de rodas de conversa e oportunizar o acesso a práticas corporais e/ou atividades físicas. Considerações finais: Equipes multiprofissionais devem facilitar o acesso à informação e ao suporte especializado, encorajando as mulheres a adotarem hábitos de autocuidado, incluindo atividades físicas e lazer visando melhorias na qualidade de vida e saúde.
Menopause Education: Intersectorial approaches, conversational circles and body practices for women in menopausal transition
Authors: Vasconcelos Liliane Ribeiro , Bonfante Ivan Luiz Padilha , Ramkrapes Ana Paula Boito , Cavaglieri Cláudia Regina
Published: February 2025

Introduction: Menopause is a natural event in a woman’s life that marks the end of the reproductive period. It is characterized by physical and psychological symptoms caused by the cessation of ovarian hormone production, which can lead to health and quality of life issues. Physical activity has been an important tool in Primary Health Care to minimize the effects of this period. However, several barriers, such as social and emotional factors, lack of infrastructure, and safety concerns, limit these women’s access to an active lifestyle. Additionally, there is still a lack of information and knowledge about this stage of life and how physical activities can beneficially influence it. Objective: To propose an educational intervention model focused on disseminating information about menopause through discussion groups and providing access to physical activities and body practices. Final considerations: Multidisciplinary teams should facilitate access to information and specialized support, encouraging women to adopt self-care habits, including physical activities and leisure, aiming to improve their quality of life and health.
An Anatomy of Crypto-Enabled Cybercrimes
Authors: Cong Will , Harvey Campbell , Rabetti Daniel , Wu Zong-Yu
Published: February 2025

The advent of cryptocurrencies and digital assets holds the promise of improving financial systems by offering cheap, quick, and secure transfer of value. However, it also opens up new payment channels for cybercrimes. Assembling a diverse set of public on- and off-chain, proprietary, and hand-collected data, including attacker–victim negotiations and dark web conversations in Russian, we present an initial anatomy of crypto-enabled cybercrimes, highlighting relevant economic issues and proposing areas for future research. Among others, we find ransomware, as the most dominant organized crypto-enabled cybercrime, entails criminal gangs that operate like firms who adopt modern revenue models and carefully manage their reputations. We suggest that blanket restrictions on cryptocurrency usage may prove counterproductive. Instead, blockchain transparency enables effective forensics for tracking, monitoring, and shutting down dominant cybercriminal organizations, which potentially facilitates a more secure and reliable crypto ecosystem in the longer term.

This paper was accepted by David Simchi-Levi, finance.

Funding: This work was supported by the National University of Singapore (NUS), Ripple’s University Blockchain Research Initiative (UBRI), the Israel Science Foundation (ISF), and the Cornell FinTech Initiative.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.03691 .
Multichannel Advertising: Budget Allocation in the Presence of Spillover and Carryover Effects
Authors: Chen Huijun , Chen Ying-Ju , Park Sung-Hyuk , Shin Dongwook
Published: February 2025

Problem definition: This paper explores budget allocation strategies for a multichannel ad campaign, where a marketing agency strives to maximize the total conversions by dynamically adjusting budget allocation over marketing channels. A salient feature of the problem is the interplay of spillover and carryover effects; namely, customers are exposed to ads through multiple channels, and thus ads from one channel affect the effectiveness of the subsequent ads from other channels. Methodology/results: We construct a simple model that captures the essential features of this problem. Our theoretical analysis yields two main insights. First, motivated by common practice based on the last-click attribution method, we examine a class of budget allocation policies that are oblivious to the spillover and carryover effects. If the agency decreases the budget on a channel based on past low conversions while neglecting to account for the fact that the ads from that channel induced conversions through other channels, then the conversions from that channel will decrease. Consequently, the agency will further decrease the budget on the channel. This pattern repeats, eventually leading to suboptimal performance in the long run. Second, we derive a fluid approximation to consumer dynamics across multiple channels, which lends itself to characterizing structural properties of optimal dynamic budget allocation policies that internalize the cross-channel interactions. To enable practical implementation, we propose a static budget allocation policy that is both tractable in practice and near optimal for long campaigns. Managerial implications: Our theoretical results provide normative guidance for budget allocation in multichannel ad campaigns. We illustrate the efficacy of our proposed method through a numerical study based on data from an online multichannel ad campaign.

Funding: This work was supported by the Hong Kong Research Grants Council [ECS Grant 26504219, GRF Grant 16212821, C6020-21GF].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.0293 .
Competitiveness Strategy in Facing Sustainable Economic Development on Social Economic Basis in Indonesia
Authors: Citra Try Citra Puspitasari Lubis
Published: February 2025

Currently, what makes one of the human economies grow is economic development, especially in the new era, development is encouraged for the environmental domain, including in the socio-economic field. This paper aims to find out how the competitiveness strategy in facing sustainable economic development on the basis of socio-economic aspects sees Indonesia's position in the context of economic recovery, one of which is the problem from the economic side, namely economic growth and the social side, namely unemployment.
UM CORPO-EXPERIMENTO NA EDUCAÇÃO DAS ARTES DE PESSOAS COM DEFICIÊNCIA VISUAL
Authors: Santos Caue de Camargo dos , de Assis Fernandes Nogueira Marina , Regina Lopes Sandra
Published: February 2025

Essa escrita faz uma contribuição ao campo da educação das artes de pessoas com deficiência visual a partir das mobilizações de afectos e perceptos (DELEUZE; GUATTARI, 2010), disparados, em uma formação experimental em teatro inclusivo. Esses atravessamentos corporais, são colocados em operação durante os encontros de um projeto de extensão, denominado Grupo de Experimentação em Artes do Corpo (GEACORP), e ofertado em uma instituição especializada na educação de pessoas com deficiência visual, no município do Rio de Janeiro. Nesse contorno, o que se pretende, é provocar o pensamento acerca da noção de corpo-experimento enquanto uma superfície que acolhe os acionamentos de memórias e saberes corporais constituídos – e tornando-os potências criadoras – na convivência com a deficiência visual. Para tanto, utiliza-se da combinação de abordagens e treinamentos corporais – os Viewpoints – delineados por Bogart e Landau (2017). Desse modo, ao cartografar essas mobilizações corporais através das rodas de conversa ao longo dos encontros do grupo, observa-se a inscrição e a tessitura de atravessamentos causados pelos afectos e perceptos transbordados no corpo-experimento. Assim, os procedimentos adotados, no projeto em questão, vêm criando possibilidades na produção de sentidos diante de uma percepção da diferença de corpos que irrompem (ao seu modo e em meio a experimentação) alguns limites impostos pela deficiência visual.
INTELIGÊNCIA ARTIFICIAL NA EDUCAÇÃO BÁSICA: UM MAPEAMENTO SISTEMÁTICO DA LITERATURA
Authors: Campelo Costa Leomar , Andressa Costa Melonio Poliana , Dos Santos Mendonça Neto Valter , Márcia Ribeiro de Souza Serra Ilka
Published: February 2025

Os debates teórico-metodológicos que discutem a Inteligência Artificial na Educação Básica e suas (im) possibilidades e desafios para a melhoria da qualidade do ensino ofertado, tem ganhado cada vez mais destaque na comunidade científica-acadêmica. A Inteligência Artificial (IA) vem se apresentando como estratégia fundante para potencializar o processo de ensino-aprendizagem, sobretudo se considerarmos o princípio da personalização do ensino; em contrapartida, a formação dos professores não consegue acompanhar o acelerado desenvolvimento dessas perspectivas tecnologias, o que causa uma rejeição entre os docentes acerca da utilização da inteligência artificial como recurso de ensino. Por outro lado, os discentes, que fazem uso da IA e de suas ferramentas, precisam aprender a forma ética, transparente e responsável de utilizá-las. Nesse sentido, este estudo se constitui em um mapeamento sistemático considerando as produções científicas publicadas entre os anos 2019 a 2023, e foi realizado nas bases de dados Scielo, Google Scholar e Portal Capes. Os resultados revelaram que a compreensão do alcance da IA, enquanto recurso pedagógico que potencialize a aprendizagem, é um processo em ascensão. O levantamento mostrou que os trabalhos, em sua maioria de caráter bibliográfico, visaram apresentar e ensinar os seus principais conceitos, principalmente para alunos do ensino médio, assim como entender e propor recursos e estratégias de sua aplicação no campo educacional.
ANÁLISE DOS ESTILOS DE APRENDIZAGEM NA EDUCAÇÃO A DISTÂNCIA: USO DE ALGORITMOS INTELIGENTES
Authors: Nascimento Elizane Silva do , Rodrigues de Souza Míriam Síria , COSTA ROBERTO DOUGLAS DA
Published: February 2025

A Inteligência Artificial (IA) é um tema em pauta nas pesquisas e estudos acadêmicos na área de Educação, embora ela já faça parte das nossas atividades cotidianas, tem atravessado, nos últimos anos, os processos educativos e ainda há muitas possibilidades de estudos que a utilizem na busca por soluções educacionais na modalidade de Educação a Distância (EAD). Este artigo busca analisar os resultados de um projeto institucional intitulado “A Teoria dos Estilos de Aprendizagem Aplicada ao Ensino a Distância”. A pesquisa foi desenvolvida no período de 2020 a 2023. Para a coleta dos dados foi utilizado um questionário CHAEA 32 e para análise dos dados foi adotado o método hipotético-dedutivo. A pesquisa foi desenvolvida em cinco fases: revisão literária sistemática; preenchimento do questionário CHAEA 32 (adaptado); análise dos dados (identificação dos Estilos de Aprendizagem predominantes dos alunos); implementação (reconhecimento dos comportamentos dos alunos); execução (correlacionar os Estilos de Aprendizagem identificados com os comportamentos conhecidos). Neste trabalho, como referencial teórico foi adotado o conceito de Estilos de Aprendizagem definido por Alonso, Gallego e Honey (2002), Cavellucci (2006) e Costa (2022). Para a definição de IA, foram utilizados os conceitos de Russell e Norvig (2013). Nos resultados, os dados apontam que, a partir do conjunto de 120 alunos divididos em cinco turmas de um curso de formação em EAD, que responderam voluntariamente o questionário CHEA32, observa-se que não há correlação entre esses estilos e as variáveis de comportamento utilizadas no estudo. Além do resultado da análise dos dados do Ambiente Virtual de Aprendizagem, uma contribuição importante deste trabalho foi poder comprovar que apenas a identificação dos comportamentos dos alunos no Ambiente Virtual de Aprendizagem é insuficiente para detectar o seu Estilo de Aprendizagem padrão, principalmente porque esses comportamentos sofrem influência de outros fatores externos como sociais, ambientais e fisiológicos.  
Palavras-chave: Educação a Distância; Estilos de Aprendizagem; Algoritmos inteligentes.
EDUCAÇÃO E INTELIGÊNCIA ARTIFICIAL: REFLEXÕES SOBRE APRENDIZAGEM SIGNIFICATIVA E FORMAÇÃO DOCENTE
Authors: Caruso Profeta Guilherme Augusto , Silveira Melo Plentz Miranda Fernando , Dos Santos Roger
Published: February 2025

Por meio de revisão bibliográfica do tipo narrativa, este artigo argumenta que, a despeito de quaisquer resistências, as IAs generativas constituem uma tecnologia com potencial de transformar a forma como se pratica e se conceitua a educação. Argumenta-se, também, que sua rápida assimilação pode superar a capacidade reflexiva da academia. Enquanto estudos anteriores sugeriram que a introdução desse tipo de IA deve redirecionar a função docente, no sentido de estimular perguntas complexas que favoreçam a exaptação, este estudo defende que, para que isso aconteça, e para que a aprendizagem seja de fato significativa, educadores devem ser expostos a processos de formação docente que permitam uma compreensão funcional das IAs em questão, especialmente questões epistemológicas, suas limitações e amplas implicações éticas.
EDUCAÇÃO PELA MEMÓRIA: A IA REDEFINIRÁ A VERDADE HISTÓRICA DOS FATOS?
Authors: De Oliveira Felix de Almeida Fernanda , Carriço de Almeida Wallace
Published: February 2025

Este artigo explora o impacto da inteligência artificial (IA) na educação, questionando se a tecnologia pode redefinir a verdade histórica dos fatos. Com foco na memória e na interpretação de eventos passados, discute-se como algoritmos podem influenciar a percepção coletiva da história. Analisam-se os benefícios da IA na acessibilidade e na personalização do aprendizado, assim como os desafios éticos e epistemológicos relacionados à objetividade histórica e à narrativa dominante. Conclui-se com reflexões sobre como educadores e sociedade podem navegar nesse novo paradigma educacional de forma crítica e responsável.
INTELIGÊNCIA ARTIFICIAL E EDUCAÇÃO: UMA REVISÃO SISTEMÁTICA DAS TESES DE DOUTORADO DEFENDIDAS ENTRE 2019 E 2023
Authors: Bassani Maria , Gonzales Chena Ana Eugênia
Published: February 2025

O artigo analisa as teses de Doutorado defendidas e publicadas no Brasil entre 2019 e 2023 que exploram a relação entre inteligência artificial (IA) e educação, utilizando a Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) como fonte de dados. A pesquisa, de caráter exploratório e apoiada por uma revisão sistemática, revela um panorama de crescimento e diversificação na área. Houve um aumento significativo na produção de teses a partir de 2022, evidenciando um crescente interesse acadêmico. As teses foram agrupadas em quatro categorias temáticas principais: IA na educação, Tecnologias digitais e redessociais na educação, Metodologias e propostas educacionais inovadoras, e Sistemas robóticos e adaptativos na educação. A diversidade temática destaca a interdisciplinaridade necessária para enfrentar os desafios contemporâneos da educação mediada por IA. Em conclusão, o estudo aponta para um futuro promissor na interseção entre IA e educação, com um reconhecimento crescente da importância dessa integração para aprimorar práticas pedagógicas e desenvolver novas metodologias e ferramentas educacionais.
INCORPORAÇÃO DA INTELIGÊNCIA ARTIFICIAL NAS AULAS DE MATEMÁTICA POR MEIO DA SUA APLICABILIDADE NO FUTEBOL
Authors: Soriano Mariana da Silva , Santos Edméa
Published: February 2025

Esta pesquisa abordou uma proposta de diálogo nas aulas de matemática acerca das transformações tecnológicas ocasionadas pela inteligência artificial (IA), de forma contextualizada com o futebol. O objetivo desse trabalho foi incorporar a inteligência artificial nas aulas de matemática através da sua aplicabilidade no futebol, dialogando com a construção de conhecimentos de conteúdos de estatística, geometria e porcentagem, por um viés da educação matemática crítica. A metodologia utilizada é a pesquisa-formação multirreferencial, tendo como contexto a docência na cibercultura, pesquisando em sintonia com o exercício docente. Ademais, a investigação se deu por meio de uma proposta e experienciação de uma sequência didática, sendo os praticantes culturais estudantes de uma turma do ensino médio. Esta pesquisa justifica-se pela necessidade da construção de estudantes críticos e reflexivos acerca das consequências que do avanço da IA e suas implicações em nossa sociedade. Mas a questão colocada é: as aulas de matemática podem contribuir com a formação de cidadãos críticos no que concerne às transformações tecnológicas causadas pela IA? Através do desenvolvimento desse estudo, foi possível discorrer sobre os pontos positivos, contrapontos e questões éticas que atravessam a IA e sua aplicabilidade no futebol, sendo possível observar que apesar de os alunos estarem imersos na era tecnológica, ainda precisam refletir sobre o uso correto e ético das tecnologias a seu favor, bem como entender as consequências das transformações que estão ocorrendo nos últimos anos em nossa sociedade.
VALIDACIÓN DE UNA VERSIÓN REDUCIDA DE LA ESCALA DE RESILIENCIA SV-RES
Authors: Regalado Piñero Jonathan Jesús , Ramírez Santana Gustavo Mario , Torbay Betancor Ángela Esther
Published: February 2025

La resiliencia como paradigma, ha promovido un cambio en el Trabajo Social en general y en el Trabajo Social Clínico en particular, no sólo en la naturaleza de los marcos conceptuales, sino también en las metas, las estrategias y las evaluaciones que se desarrollan en la interven-ción. Para poder desarrollar intervenciones efi-caces bajo este enfoque resulta necesario disponer de instrumentos de medición estandarizados en el proceso de evaluación. La Escala de Resiliencia para Jóvenes y Adultos SV-RES (Saavedra y Villalta, 2008) es un instrumento que resulta de alto valor por evaluar la resiliencia desde una perspectiva multidimensional, multifactorial e inte-raccional. Este estudio se desarrolló siguiendo un método transversal con un diseño descriptivo-correlacional y permitió la validación de una versión reducida de la Escala de Resiliencia SV-RES, consiguiendo que el instrumento pase de 60 a 36 ítems, sin perder las excelentes propiedades psicométricas.
LA IMPORTANCIA DE LO DIALÓGICO EN LA INTERVENCIÓN SOCIAL A PARTIR DEL TEXTO CONVERSACIÓN LENGUAJE Y POSIBILIDADES DE HARLENE ANDERSON
Authors: Aparicio Jiménez Carlos
Published: February 2025

Al estudiar Trabajo Social, y corroborar en la práctica profesional; siempre he pensado que nuestra disciplina en cuanto supera el ámbito de la gestión, se vuelve una actividad terapéutica. El mismo hecho del relato, ante el planteamiento de ayuda, connota la mínima reflexión que, como tal, siempre incidirá en nuevos análisis, un recorrido hacia nuevas posibilidades.
A través del texto de Anderson, indago a la par que relacionó con la intervención social, sobre la importancia del lenguaje, y como este debe amoldarse y estructurarse a partir de los significa-dos, reconociendo que en estos significados están las claves de nuestra intervención. La Terapia Colaborativa y el Trabajo Social: el proceso.
Y como proceso la historia y su repercusión que, no olvidemos, es la conversación y lo que transciende desde ella.
Assessment of Alternative Controller Tuning Techniques for Systems without Ultimate Parameters
Authors: Uniyal Ishita , Thakur Padmanabh , Saini Parvesh
Published: February 2025

This work presented in this article aims at designing and analysingalternate methods for tuning of the Proportional – Integral – Derivative (PID) controller for the plants that do not possess the ultimate parameters (ultimate gain and ultimate period). The motivation lies in the fact that the conventional methods such as the Ziegler-Nichols (Z-N) approach require the ultimate parameters for designing the PID controllers. However, because there exist some plants which do not have these parameters, and hence it is difficult to design controllers for such plants using conventional approaches directly. So, there is a need of using some alternative ways to design controllers for such plants. So, in the presented work, Particle Swarm Optimization (PSO), Extended Forced Oscillations (EFO), and Internal Model Control (IMC) methods have been applied for designing PID controllers suitable for such a plant. All the techniques were tested for their capability in optimizing control performance on rise time, settling time, overshoot, and error indices like Integral of Absolute Error (IAE), Integral of Squared Error (ISE), Integral of Time-Weighted Absolute Error (ITAE), and Integral of Time Squared Error (ITSE). Special attention was given to the objective function of ITAE minimization for the PSO-based PID controller. The results show that out of various approaches, the PSO-based PID controller provides the fastest response with minimum overshoot and low values of errors compared to EFO-based and IMC-based PID controllers. The EFO-based PID controller gave a mediocre performance while the IMC-based PID turned out to be the worst, giving a response that was the slowest with maximum errors. This work is carried out for a comprehensive comparison of various alternative tuning approaches, and it presents PSO-based PID as the most robust and reliable solution for plants with no ultimate parameters hence proposes it as an efficient alternative to conventional PID tuning strategies.
Suitability of Recycled Aggregates for Application in Structural Concrete: Experimental Study
Authors: Gyadi Tado , Basack Sudip
Published: February 2025

Demolition wastes have been increasing day by day as the age-old concrete structures are to be replaced for a new one. In order to reduce the impact of this demolished concrete in nature, recycling it as coarse aggregates appearsto be a highly sustainable option. Recycled aggregates comprise crushed, graded inorganic particles processed from the materials that have been used in the construction and demolition debris. The aim of this project is to determine the suitability of recycled aggregates for application in structural concrete in terms of strength and serviceability criteria. The initial questions concerning the strength of aggregate and workability enhancement aredue to the associated mortar content. Few tests were conducted on the properties of the new aggregate, such as specific gravity, water absorption, and aggregate crushing value. Properties of concrete such as compression strength, splitting tensile strength, flexural strength, and modulus of elasticity were found out. Finally, the application of recycled coarse aggregates in pavement construction was studied. A brief comparison of the cost efficiency was also evaluated.