bluuebunny/crossref_metadata_2025 huggingface dataset:
Binge Eating and Binge Drinking in Emerging Adults During COVID-19 Lockdown in Italy: An Examination of Protective and Risk Factors
Authors: Bianchi Dora , Baiocco Roberto , Pompili Sara , Lonigro Antonia , Di Norcia Anna , Cannoni Eleonora , Longobardi Emiddia , Zammuto Marta , Di Tata Daniele , Laghi Fiorenzo
Published: December 2021

This study investigated binge behaviors during COVID-19 lockdown in Italy, exploring individual and contextual risk factors. Participants were 1925 emerging adults ( M age = 24.18, SD age = 2.75; 71.9% women), recruited during the national lockdown in Italy. An online survey investigated binge behaviors both prior and during quarantine. Binge drinking significantly diminished during quarantine, while binge eating episodes did not vary in frequency. However, participants with pre-existent binge eating disorder (BED) reported a worsening in BED symptoms. Lower education, lower SES, job suspension due to lockdown, and higher pandemic-related stress were associated to an increase in binge behaviors during home confinement, whereas living with family was a protective factor. Participants reporting co-occurrent binge behaviors also had significantly higher pandemic-related stress and lower perceived support during home confinement, in comparison with no-binge participants. The study provides new insights about protective and risk factors for binge behaviors in emerging adults during COVID-19 lockdown.
Effectiveness of prophylactic vitamin C supplementation in the prevention of complex regional pain syndrome after distal end radius fractures in the aging population
Authors: Sane Rohit M , Samant Prakash D , Butala Rajendraprasad R
Published: December 2021

Background/purpose

Vitamin C has been proposed to prevent the incidence of complex regional pain syndrome, but the results are conflicting. We evaluated the effectiveness of vitamin C in the prevention of complex regional pain syndrome-1 after distal end radius fractures in the aging population.

Methods

This was a prospective, randomized study. Patients treated with either conservative or surgical management for distal end radius fracture received Vitamin C (500 mg/day) plus standard therapy or standard therapy alone for a period of 3 months. The presence of complex regional pain syndrome-1 was assessed with Budapest criteria.

Results

The complex regional pain syndrome-I occurred in 11.3% in Vitamin C plus Standard in compared to 26% in Standard therapy alone. Vitamin C was significantly associated with a reduction in the likelihood of exhibiting complex regional pain syndrome-1.

Conclusion

Vitamin C (500 mg/day) supplementation was effective and associated with a lower occurrence of acute complex regional pain syndrome-1. It can be a promising prophylactic option for the prevention of complex regional pain syndrome-1 after distal end radius fracture.
Longitudinal Interprofessional Family-Based Experience (LIFE): An Authentic Experiential Interprofessional Education Learning Framework
Authors: Mattison Debra , Smith Laura J. , Balzer Kate , Bavireddy Vinoothna , Bishop Thomas W. , Farris Karen , Fitzgerald Mark , Rulli Danielle , Trupiano Nicole , Anderson Olivia S.
Published: December 2021

The Longitudinal Interprofessional Family-Based Experience (LIFE) was developed to address the need for longitudinal, experiential IPE opportunities that bring students together with real patient-family units with an intentional plan for multiple qualitative and quantitative evaluation measures. LIFE engaged 48 early learners from eight health science schools at a large midwestern university in ongoing team skill-based interactions coupled with real patient experiential learning over 11 weeks. Student teams were introduced and encouraged to apply the socio-ecological model (SEM) and social determinants of health (SDH) while collaboratively exploring the impact of the patient-family’s interface with the healthcare system and community during two consecutive patient-family interviews. A creative collaboration with the health system’s Office of Patient Experience, provided eight patients who had experienced chronic illness and treatment in the healthcare system, who engaged with the learners as both teachers as well as evaluators in this experience. LIFE is a framework model that has applicability and adaptability for designing, implementing, and sustaining experiential IPE. Initial summary data regarding outcomes for students are presented as well as considerations to increase accessible and sustainable authentic IPE experiences through untapped patient and community collaborations.
Exploring long-term urban cycles with multivariate time-series analysis
Authors: Salvati Luca
Published: December 2021

European cities underwent long-term socioeconomic transformations resulting in a shift from centralized demographic growth typical of late industrialization to a more recent (and spatially uncoordinated) de-concentration of population and economic activities. While abandoning traditional compact models and moving toward settlement dispersion, population growth in urban areas was assumed to follow a “life cycle” constituted of four developmental stages (urbanization, suburbanization, counter-urbanization, and re-urbanization). We studied anomalies in the City Life Cycle (CLC) of a large metropolitan region (Athens, Greece) with the aim at achieving a less mechanistic interpretation of long-term population growth in complex social contexts. Using population data that cover more than 170 years (1848–2020) and multivariate time-series analysis, a non-linear growth history was delineated, with sequential accelerations and decelerations characteristic of the first CLC stage (urbanization). Considering the classical division in three radio-centric districts (core, ring, and agglomeration), different development stages coexisted since World War II. Heterogeneous suburbanization processes mixed up with late urbanization and weaker impulses of counter-urbanization and re-urbanization. The empirical results of time-series analysis confirm the non-linear expansion of Athens, shedding further light on long-term mechanisms of metropolitan development and informing management policies of urban growth.
Accuracy of Weightbearing CT Scans for Patient-Specific Instrumentation in Total Ankle Arthroplasty
Authors: Thompson Mitchell J. , Consul Devon , Umbel Benjamin D. , Berlet Gregory C.
Published: December 2021

Background:

Total ankle arthroplasty (TAA) is a popular and viable option for end-stage ankle arthritis. Posttraumatic arthritis is the most common etiology of ankle arthritis, which creates the additional challenge of osseus deformity. Accuracy and reproducibility in placing the implant on the mechanical axis has been shown to be paramount in all joint arthroplasty including total ankle replacement. Patient-specific preoperative navigation is a relatively new technology for TAA, and up until this past year has been based off of nonweightbearing (NWBCT) or simulated weightbearing computed tomography (WBCT). Our institution has created a protocol to use WBCT in the preoperative patient-specific navigation for TAA using the Prophecy system. The purpose of our study was to compare the accuracy and reproducibility of implant alignment and size using WBCT vs prior studies using NWBCT for the Prophecy reports.

Methods:

All patients from July 2019 through October 2020 who underwent TAA were evaluated. Inclusion criteria consisted of primary TAA using patient-specific preoperative navigation who had postoperative radiographs in the 4-6-week time frame. Prophecy predictions and measurements were then compared to actual implant placement and size.

Results:

Ten patients met our inclusion criteria of WBCT Prophecy preoperative planning using 2 different implant systems. Preoperative deformities in this cohort were small. The average postoperative coronal alignment was 0.84 degrees, range 0.19 to 2.4 degrees. Average postoperative sagittal plane deformity was 1.9 degrees, range 0.33 to 5.05 degrees. Tibial component size was properly predicted in all patients, talar component in 9 of 10.

Conclusion:

This initial report supports accuracy and reproducibility in preoperative patient-specific navigation when using WBCT for TAA with these implants. All TAAs were within the intended target of less than 5 degrees varus or valgus.

Level of Evidence:

Level III, retrospective comparative analysis.
Results of a web-based questionnaire: A gender-based study of migraine with and without aura and possible differences in pain perception and drug effectiveness
Authors: Drescher Johannes , Amann Tina Katharina , Gaul Charly , Kropp Peter , Siebenhaar Yannic , Scheidt Jörg
Published: December 2021

Background:

The aim of this work is to analyze reports of migraine attacks collected online in the citizen science project CLUE with respect to gender- and migraine type-specific differences in drug effectiveness and pain perception. Citizen science project data collection opens the possibility to examine these differences based on a large number of individual attacks instead of a simple survey of patients.

Methods:

One thousand three hundred and ninety four participants reported 47,274 migraine attacks via an online platform and smartphone apps. The reports contained information on the acute medications taken, the evaluation of their effect, and information on pain parameters such as pain intensity, origin, and localization. Chi-square tests were used to investigate whether the effect of acute medications and pain parameters differed when collated by gender and migraine type (migraine with and without aura).

Results:

Our participants rated the effectiveness of triptans as significantly better than that of ibuprofen. For triptans, significant differences in effectiveness were found when migraine types were distinguished, but no difference was found between genders. For ibuprofen, there were no differences between migraine types but significant differences between gender groups. Examination of pain parameters reveals differences between groups in pain intensity, pain origin, and pain location. The differences are statistically significant, but the effects are small.

Conclusions:

Despite some methodological limitations, web-based data collection is able to support findings from clinical trials in a real-world setting. Due to the high numbers of participants included and attacks reported, even small differences in medication efficacy and pain parameters between the groups considered can be demonstrated to be statistically significant.
Multimodal imaging in pediatric uveitis
Authors: Diala Fitz Gerald I. , McCarthy Kayne , Chen Judy L. , Tsui Edmund
Published: December 2021

Pediatric uveitis accounts for up to 10% of all uveitis cases, so special attention must be paid to ensure early diagnosis as well as treatment and follow-up of these young patients in order to decrease the risk of possible ocular complications and consequently vision loss. Multimodal imaging has been an effective and important adjunct in the diagnoses and management of uveitis, especially in children. Reviewed here are the currently utilized modalities, advances, as well as their applications in juvenile idiopathic arthritis–associated uveitis, pars planitis, retinal vasculitis, tubulointerstitial nephritis and uveitis syndrome, Behçet disease, Blau syndrome, and Vogt–Koyanagi–Harada syndrome.
Reflections on Teaching General Music Online During Lockdown
Authors: Norman Timothy David
Published: December 2021

In this column, I reflect on my experiences teaching online during lockdown. In particular, I discuss the benefits and disadvantages of prerecorded lessons, when compared with live Zoom sessions, for elementary general music classes.
Self-centering seismic-resistant structures: Historical overview and state-of-the-art
Authors: Zhong Chiyun , Christopoulos Constantin
Published: December 2021

This state-of-the-art review provides an overview of the evolution of self-centering structures from early historical structures that inherently exhibited a recentering response to modern systems engineered for enhanced seismic resilience. From the early research investigations that were conducted since the 1960s, to the sharp increase of interest in this topic over the last two decades, self-centering seismic-resistant structures that can mitigate both damage and residual drifts following major earthquakes have seen significant advances. These systems achieve the intended self-centering response by either allowing for the rocking of primary structural elements in a controlled manner, commonly coupled with mechanical restraints and energy dissipation devices, or by including self-centering devices as main structural or supplemental structural members. To better explain the concepts and the underlying mechanics governing their seismic response, detailed schematic illustrations were developed in this article, highlighting the fundamentals behind each of these systems. This article covers a historical overview, presents the state of the research and of the art, discusses general design challenges and practical considerations, and concludes with future research needs to advance the development and broader application of self-centering systems in real structures.
Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction
Authors: Muckenthaler Lena , Marques Oriana , Colucci Silvia , Kunz Joachim , Fabrowski Piotr , Bast Thomas , Altamura Sandro , Höchsmann Britta , Schrezenmeier Hubert , Langlotz Monika , Richter-Pechanska Paulina , Rausch Tobias , Hofmeister-Mielke Nicole , Gunkel Nikolas , Hentze Matthias W. , Kulozik Andreas E. , Muckenthaler Martina U.
Published: December 2021

Muckenthaler et al describe a novel form of hemochromatosis caused by a constitutional PIGA mutation in 3 children with associated neurologic dysfunction. Hemochromatosis results from decreased hepcidin, which is regulated by HFE, hemojuvelin (HJV), and transferrin receptor 2. HJV is a glycosylphosphatidylinositol-linked protein, so PIGA mutation leads to decreased HJV expression. Interestingly, none of the children had evidence of paroxysmal nocturnal hemoglobinuria. The cause of the novel association with central nervous system manifestations remains to be elucidated.
Full-length transcriptomic identification of R2R3-MYB family genes related to secondary cell wall development in Cunninghamia lanceolata (Chinese fir)
Authors: Zhuang Hebi , Chong Sun-Li , Priyanka Borah , Han Xiao , Lin Erpei , Tong Zaikang , Huang Huahong
Published: December 2021

Background

R2R3-MYB is a class of transcription factor crucial in regulating secondary cell wall development during wood formation. The regulation of wood formation in gymnosperm has been understudied due to its large genome size. Using Single-Molecule Real-Time sequencing, we obtained full-length transcriptomic libraries from the developmental stem of Cunninghamia lanceolata, a perennial conifer known as Chinese fir. The R2R3-MYB of C. lanceolata (hereafter named as ClMYB) associated with secondary wall development were identified based on phylogenetic analysis, expression studies and functional study on transgenic line.

Results

The evolutionary relationship of 52 ClMYBs with those from Arabidopsis thaliana, Eucalyptus grandis, Populus trichocarpa, Oryza sativa, two gymnosperm species, Pinus taeda, and Picea glauca were established by neighbour-joining phylogenetic analysis. A large number of ClMYBs resided in the woody-expanded subgroups that predominated with the members from woody dicots. In contrast, the woody-preferential subgroup strictly carrying the members of woody dicots contained only one candidate. The results suggest that the woody-expanded subgroup emerges before the gymnosperm/angiosperm split, while most of the woody-preferential subgroups are likely lineage-specific to woody dicots. Nine candidates shared the same subgroups with the A. thaliana orthologs, with known function in regulating secondary wall development. Gene expression analysis inferred that ClMYB1/2/3/4/5/26/27/49/51 might participate in secondary wall development, among which ClMYB1/2/5/26/27/49 were significantly upregulated in the highly lignified compression wood region, reinforcing their regulatory role associated with secondary wall development. ClMYB1 was experimentally proven a transcriptional activator that localised in the nucleus. The overexpression of ClMYB1 in Nicotiana benthamiana resulted in an increased lignin deposition in the stems. The members of subgroup S4, ClMYB3/4/5 shared the ERF-associated amphiphilic repression motif with AtMYB4, which is known to repress the metabolism of phenylpropanoid derived compounds. They also carried a core motif specific to gymnosperm lineage, suggesting divergence of the regulatory process compared to the angiosperms.

Conclusions

This work will enrich the collection of full-length gymnosperm-specific R2R3-MYBs related to stem development and contribute to understanding their evolutionary relationship with angiosperm species.
High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer
Authors: Li Fan , Sun Huizhi , Li Yue , Bai Xiaoyu , Dong Xueyi , Zhao Nan , Meng Jie , Sun Baocun , Zhang Danfang
Published: December 2021

Background

The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infiltration in breast cancer (BRCA) remain uncertain.

Methods

Oncomine, Timer and UALCAN were used to analyze the expression of eIF4E in various cancers. PrognoScan, Kaplan–Meier plotter, and GEPIA were utilized to analyze the prognostic value of eIF4E in select cancers. In vitro cell experiments were used to verify the role of eIF4E in promoting the progression of BRCA. ImmuCellAI and TIMER database were used to explore the relationship between eIF4E and tumor infiltrating immune cells. The expression of a macrophage marker (CD68+) and an M2-type marker (CD163+) was evaluated using immunohistochemistry in 50 invasive BRCA samples on tissue microarrays. The Human Protein Atlas (HPA) database was used to show the expression of eIF4E and related immune markers. LinkedOmics and NetworkAnalyst were used to build the signaling network.

Results

Through multiple dataset mining, we found that the expression of eIF4E in BRCA was higher than that in normal tissues, and patients with increased eIF4E expression had poorer survival and a higher cumulative recurrence rate in BRCA. At the cellular level, BRCA cell migration and invasion were significantly inhibited after eIF4E expression was inhibited by siRNA. Immune infiltration analysis showed that the eIF4E expression level was significantly associated with the tumor purity and immune infiltration levels of different immune cells in BRCA. The results from immunohistochemical (IHC) staining further proved that the expression of CD68+ and CD163+ were significantly increased and correlated with poor prognosis in BRCA patients (P < 0.05). Finally, interaction network and functional enrichment analysis revealed that eIF4E was mainly involved in tumor-related pathways, including the cell adhesion molecule pathway and the JAK-STAT signaling pathway.

Conclusions

Our study has demonstrated that eIF4E expression has prognostic value for BRCA patients. eIF4E may act as an essential regulator of tumor macrophage infiltration and may participate in macrophage M2 polarization.
Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design
Authors: Bekkhus Mona , Lee Yunsung , Brandlistuen Ragnhild Eek , Samuelsen Sven Ove , Magnus Per
Published: December 2021

Background

The overall aim of this study is to examine the effect of prenatal maternal anxiety on birthweight and gestational age, controlling for shared family confounding using a sibling comparison design.

Methods

The data on 77,970 mothers and their 91,165 children from the population-based Mother, Father and Child Cohort Study and data on 12,480 pairs of siblings were used in this study. The mothers filled out questionnaires for each unique pregnancy, at 17th and 30th week in pregnancy. Gestational age and birth weight was extracted from the Medical Birth Registry of Norway (MBRN). Associations between prenatal maternal anxiety (measured across the 17th and 30th weeks) and birth outcomes (birthweight and gestational age) were examined using linear regression with adjustment for shared-family confounding in a sibling comparison design.

Results

In the population level analysis the maternal anxiety score during pregnancy was inversely associated with new-born’s birthweight (Beta = -63.8 95% CI: -92.6, -35.0) and gestational age (Beta = -1.52, 95% CI: -2.15, -0.89) after adjustment for several covariates. The association of the maternal anxiety score with birthweight was no longer significant, but remained for maternal anxiety at 30th week with gestational age (Beta = -1.11, 95% CI: -1.82, -0.4) after further adjusting for the shared-family confounding in the sibling comparison design.

Conclusion

No association was found for maternal prenatal anxiety with birth weight after multiple covariates and family environment were controlled. However, there was an association between prenatal maternal anxiety at 30th week only with gestational age, suggesting a timing effect for maternal anxiety in third trimester.
The association between sexual function and body image among postmenopausal women: a cross-sectional study
Authors: Nazarpour Soheila , Simbar Masoumeh , Khorrami Mobina , Jafari Torkamani Zahra , Saghafi Reyhaneh , Alavi-Majd Hamid
Published: December 2021

Background

Postmenopause physiological changes may alter body image (BI) during the postmenopausal period of life. Body image dissatisfaction may have negative effects on the sexual function of women. The present study aims to assess the relationship between body image and sexual function during the postmenopausal period.

Methods

This cross-sectional study was performed on 231 postmenopausal women who were menopausal during the recent 5 years, aged > 40 years old, and referring to health centers in Tehran-Iran. The participants were recruited using a multi-stage sampling method. Data were collected using 3 questionnaires including socio-demographic, Fisher’s Body Image, and female sexual function index (FSFI). Data were analyzed using SPSS 24 and multiple regression, Mann–Whitey, Pearson, and Spearman correlation tests.

Results

Two hundred thirty-one postmenopausal women aged 52.53 ± 5.32 (mean ± SD) years old participated in the study. The mean and standard deviation of FSFI and BI of the women were respectively 19.59 ± 11.11(ranges 1.2–36) and 155.43 ± 37.09 (ranges from 46 to 230). According to FSFI, 62.8% of female sexual dysfunction (FSD) was reported. There were significant correlations between scores of total and all domains of FSFI with scores of total and all dimensions of BI. There was also a positive correlation between education and family income of the women and a negative correlation between age of husband and duration of menopause with their sexual function. Significant relationships were also shown between the women's and the husbands' jobs with the total score of women's sexual function. According to the multiple linear regression model, BI was a significant predictor of sexual function in postmenopausal women.

Conclusion

Body image is effective on the sexual function of postmenopausal women. Therefore, body image is necessary to be considered in future postmenopausal health promotion programs.
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy
Authors: Linville Raleigh M. , Searson Peter C.
Published: December 2021

With the limitations associated with post-mortem tissue and animal models, In vitro BBB models enable precise control of independent variables and microenvironmental cues, and hence play an important role in studying the BBB. Advances in stem cell technology and tissue engineering provide the tools to create next-generation in vitro BBB models with spatial organization of different cell types in 3D microenvironments that more closely match the human brain. These models will be capable of assessing the physiological and pathological responses to different perturbations relevant to health and disease. Here, we review the factors that determine the accuracy of in vitro BBB models, and describe how these factors will guide the development of next-generation models. Improving the accuracy of cell sources and microenvironmental cues will enable in vitro BBB models with improved accuracy and specificity to study processes and phenomena associated with zonation, brain region, age, sex, ethnicity, and disease state.
Analytical setup margin for spinal stereotactic body radiotherapy based on measured errors
Authors: Copeland Audrey , Barron Addie , Fontenot Jonas
Published: December 2021

Background

No consensus currently exists about the correct margin size to use for spinal SBRT. Margins have been proposed to account for various errors individually, but not with all errors combined to result in a single margin value. The purpose of this work was to determine a setup margin for five-fraction spinal SBRT based on known errors during radiotherapy to achieve at least 90% coverage of the clinical target volume with the prescription dose for at least 90% of patients and not exceed a 30 Gy point dose or 23 Gy to 10% of the spinal cord subvolume.

Methods

The random and systematic error components of intrafraction motion, residual setup error, and end-to-end system accuracy were measured. The patient’s surface displacement was measured to quantify intrafraction motion, the residual setup error was quantified by re-registering accepted daily cone beam computed tomography setup images, and the displacement between measured and planned dose profiles in a phantom quantified the end-to-end system accuracy. These errors and parameters were used to identify the minimum acceptable margin size. The margin recommendation was validated by assessing dose delivery across 140 simulated patient plans suffering from various random shifts representative of the measured errors.

Results

The errors were quantified in three dimensions and the analytical margin generated was 2.4 mm. With this margin applied in the superior/inferior direction only, at least 90% of the CTV was covered with the prescription dose for 96% of the 140 patients simulated with minimal negative effect on the spinal cord dose levels.

Conclusions

The findings of this work support that a 2.4 mm margin applied in the superior/inferior direction can achieve at least 90% coverage of the CTV for at least 90% of dual-arc volumetric modulated arc therapy spinal SBRT patients in the presence of errors when immobilized with vacuum bags.
Studies on the effects of hypothermia combined with hypoxia on rat skeletal muscle and lipid metabolism based on AMPK/PGC1α pathway
Authors: Ruixia Zhang , chuanchuan Liu , Lu Guan , Shuang Ma , Qiang Zhu , Xiaofang Tian , Yinggui Ba
Published: December 2021

Aim

To explore the effects of hypothermia and hypoxia on rat skeletal muscle and lipid metabolism.

Method

Forty male rats were randomly divided into blank group, low-temperature group, hypoxia group, and hypothermia combined with hypoxia group. The body weight of the rats was monitored. The changes of Irisin were detected by ELISA, and LDL, HDL, TC, and TG levels in serum were detected by blood biochemistry. Western blot was used to detect the changes of lipid metabolism-related proteins. CCK8 was used to verify the effect of AMPK/PGC1α on the proliferation of rat skeletal muscle cells.

Result

In the case of cold stimulation and hypoxia, the weight of the rats decreased significantly, and the levels of LDL, HDL, TC, and TG in the serum were abnormal. The activity of fatty acid metabolism factors Irisin, UCP-1, and FABP4 is down-regulated by hypothermia and hypoxia. The activity of fat metabolism-related enzymes, ATGL, HSL, and MGL increased under hypothermia and low oxygen conditions. Hypothermia and hypoxia affected the morphology of skeletal muscle, and AMPK/PGC-1α can regulate the proliferation of skeletal muscle cells.

Conclusion

Hypothermia and hypoxia can reduce the body weight of rats, and affect the structure of skeletal muscle to promote lipid metabolism through AMPK/PGC-1α signaling pathway.
Lahar risk assessment from source identification to potential impact analysis: the case of Vulcano Island, Italy
Authors: Gattuso Alessandro , Bonadonna Costanza , Frischknecht Corine , Cuomo Sabatino , Baumann Valérie , Pistolesi Marco , Biass Sebastien , Arrowsmith J. Ramon , Moscariello Mariagiovanna , Rosi Mauro
Published: December 2021

Lahars are rapid flows composed of water and volcaniclastic sediments, which have the potential to impact residential buildings and critical infrastructure as well as to disrupt critical services, especially in the absence of hazard-based land-use planning. Their destructive power is mostly associated with their velocity (related to internal flow properties and topographic interactions) and to their ability to bury buildings and structures (due to deposit thickness). The distance reached by lahars depends on their volume, on sediments/water ratio, as well as on the geometrical properties of the topography where they propagate. Here we present the assessment of risk associated with lahar using Vulcano island (Italy) as a case study. First, we estimated an initial lahar source volume considering the remobilisation by intense rain events of the tephra fallout on the slopes of the La Fossa cone (the active system on the island), where the tephra fallout is associated with the most likely scenario (e.g. long-lasting Vulcanian cycle). Second, we modelled and identified the potential syn-eruptive lahar impact areas on the northern sector of Vulcano, where residential and touristic facilities are located. We tested a range of parameters (e.g., entrainment capability, consolidation of tephra fallout deposit, friction angle) that can influence lahar propagation output both in terms of intensity of the event and extent of the inundation area. Finally, exposure and vulnerability surveys were carried out in order to compile exposure and risk maps for lahar-flow front velocity (semi-quantitative indicator-based risk assessment) and final lahar-deposit thickness (qualitative exposure-based risk assessment). Main outcomes show that the syn-eruptive lahar scenario with medium entrainment capability produces the highest impact associated with building burial by the final lahar deposit. Nonetheless, the syn-eruptive lahar scenario with low entrainment capacity is associated with higher runout and results in the highest impact associated with lahar-flow velocities. Based on our simulations, two critical infrastructures (telecommunication and power plant), as well as the main road crossing the island are exposed to potential lahar impacts (either due to lahar-flow velocity or lahar-deposit thickness or both). These results show that a risk-based spatial planning of the island could represent a valuable strategy to reduce the volcanic risk in the long term.
Living systematic reviews in rehabilitation science can improve evidence-based healthcare
Authors: Elbers S. , Wittink H. , Kaiser U. , Kleijnen J. , Pool J. , Köke A. , Smeets R.
Published: December 2021

Although systematic reviews are considered as central components in evidence-based practice, they currently face an important challenge to keep up with the exponential publication rate of clinical trials. After initial publication, only a minority of the systematic reviews are updated, and it often takes multiple years before these results become accessible. Consequently, many systematic reviews are not up to date, thereby increasing the time-gap between research findings and clinical practice. A potential solution is offered by a living systematic reviews approach. These types of studies are characterized by a workflow of continuous updates which decreases the time it takes to disseminate new findings. Although living systematic reviews are specifically designed to continuously synthesize new evidence in rapidly emerging topics, they have also considerable potential in slower developing domains, such as rehabilitation science. In this commentary, we outline the rationale and required steps to transition a regular systematic review into a living systematic review. We also propose a workflow that is designed for rehabilitation science.
Atlantis, an Autoanthropology
Authors: Tarn Nathaniel
Published: December 2021

Over the course of his long career, Nathaniel Tarn has been a poet, anthropologist, and book editor, while his travels have taken him into every continent. Born in France, raised in England, and earning a Ph.D. from the University of Chicago, he knew André Breton, Salvador Dalí, Marcel Duchamp, Margot Fonteyn, Charles Olson, Claude Lévi-Strauss, and many more of the twentieth century’s major artists and intellectuals. In Atlantis, an Autoanthropology he writes that he has "never (yet) been able to experience the sensation of being only one person.” Throughout this literary memoir and autoethnography, Tarn captures this multiplicity and reaches for the uncertainties of a life lived in a dizzying array of times, cultures, and environments. Drawing on his practice as an anthropologist, he takes himself as a subject of study, examining the shape of a life devoted to the study of the whole of human culture. Atlantis, an Autoanthropology prompts us to consider our own multiple selves and the mysteries contained within.
Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia
Authors: Thiel Whitney A. , Esposito Emma J. , Findley Anna P. , Blume Zachary I. , Mitchell Diana M.
Published: December 2021

Transcriptome analyses performed in both human and zebrafish indicate strong expression of Apoe and Apoc1 by microglia. Apoe expression by microglia is well appreciated, but Apoc1 expression has not been well-examined. PPAR/RXR and LXR/RXR receptors appear to regulate expression of the apolipoprotein gene cluster in macrophages, but a similar role in microglia in vivo has not been studied. Here, we characterized microglial expression of apoc1 in the zebrafish central nervous system (CNS) in situ and demonstrate that in the CNS, apoc1 expression is unique to microglia. We then examined the effects of PPAR/RXR and LXR/RXR modulation on microglial expression of apoc1 and apoeb during early CNS development using a pharmacological approach. Changes in apoc1 and apoeb transcripts in response to pharmacological modulation were quantified by RT-qPCR in whole heads, and in individual microglia using hybridization chain reaction (HCR) in situ hybridization. We found that expression of apoc1 and apoeb by microglia were differentially regulated by LXR/RXR and PPAR/RXR modulating compounds, respectively, during development. Our results also suggest RXR receptors could be involved in endogenous induction of apoc1 expression by microglia. Collectively, our work supports the use of zebrafish to better understand regulation and function of these apolipoproteins in the CNS.
Ο ναός της Παναγίας Οδηγήτριας (;) στον Αρχάγγελο Πρεβέζης (1785) Σύντομη περιγραφή και αποτίμηση
Authors: Καραλής Ηλίας , Κουτρόπουλος Γρηγόριος Χ.
Published: December 2021

Η εργασία των Καραλή-Κουτρόπουλου, αναφέρεται σε ερειπωμένο ναό του 18ου αιώνα, που βρίσκεται στο χωριό Αρχάγγελος Πρέβεζας. Μολονότι πρόκειται για ιδιαίτερα αξιόλογο μνημείο, ο ναός μέχρι σήμερα δεν έχει αποτελέσει το αντικείμενο ειδικής μελέτης. Σκοπός του παρόντος άρθρου είναι διττός, αφενός να αποτυπώσει και να τεκμηριώσει όσα περισσότερα αρχικά στοιχεία σώζονται ακόμη στο μνημείο λαμβάνοντας υπόψιν τις εγγενείς δυσκολίες μελέτης του, αφετέρου να επεξεργαστεί αυτά τα στοιχεία και να προβούν σε συμπερασματικές προτάσεις, καθώς ο ναός παρουσιάζει επιστημονικό ενδιαφέρον για την Ιστορία της Αρχιτεκτονικής και της Τέχνης.
Αστέρι, Ήλιος και Φεγγάρι
Authors: Μαρτζούχος π. Θεοδόσιος
Published: December 2021

Το παρόν κείμενο είναι επεξεργασμένη μορφή ομιλίας που δόθηκε στην παρουσίαση του βιβλίου "Άσπονδοι Αδελφοί" του Σταύρου Ζουμπουλάκη στο Πνευματικό Κέντρο Δήμου Ιωαννιτών, 4.11.2019. Πρωτοδημοσιεύτηκε στην αρχική του μορφή στις 8.11.2019 στην ιστοσελίδα του Ενοριακού Κέντρου του Ι.Ν. Αγίου Ιωάννου Χρυσοστόμου Πρεβέζης (https://www.enoriako.info/index.php/omilies/omilies/990-2019-11-08-10-35-37)
Εκλογή προξενικών αρχών της Βενετίας σε περιοχές της Δυτικής Ελλάδας κατά τον 18ο αιώνα: Δικαιοδοσία – καθήκοντα
Authors: Βέτσιος Ελευθέριος
Published: December 2021

Η παρούσα εργασία στηρίζεται σε αρχειακό υλικό που αντλήθηκε από τοΚρατικό Αρχείο της Βενετίας (Archivio di Stato di Venezia) και περιλαμβάνειτις «Commissioni», δηλαδή τις υποχρεώσεις και τα καθήκοντα, που ανέλαβανπρόξενοι της Βενετίας σε κάποιες τουρκοκρατούμενες περιοχές της ΔυτικήςΕλλάδας κατά τη διάρκεια του 18ου αιώνα.
Η δημογραφική και οικονομική πορεία της Πρέβεζας τα τελευταία 300 χρόνια
Authors: Μουστάκης Γιώργος Ιάσονος
Published: December 2021

Δεν αναφέρεται περίληψη
Τεκμήριο διδασκαλίας της γαλλικής γλώσσας στην Πρέβεζα του 19ο υ αιώνα
Authors: Τζούρου Βικτωρία , Σκλαβενίτης Σπυρίδων
Published: December 2021

Το άρθρο περιελάμβανε σύντομη εισαγωγή και μεταγραφή οκτώ ιστοριών από χειρόγραφο που σώζεται στο οικογενειακό αρχείο της πρώτης εκ των συγγραφέων, εγγονής του Στυλιανού Γιαννατζή ή Παπαγεωργίου και κόρης του στρατηγού Αλέξανδρου Παπαγεωργίου, στον οποίον είχε περιέλθει το αρχείο του πατέρα του Στυλιανού. Τεκμήρια από αυτό το οικογενειακό αρχείο έχουν ήδη δημοσιευτεί,1 ενώ παράλληλα, κατόπιν αιτήματος των ΓΑΚ – Αρχείων Ν. Πρέβεζας και θετική ανταπόκριση εκ μέρους της κατόχου του αρχείου, μεγάλο τμήμα του πρωτότυπου υλικού ψηφιοποιήθηκε και απόκειται ψηφιακά και στην αρχειακή υπηρεσία του νομού.
Περιεχόμενα τεύχους 53-54
Authors: Πρεβεζάνικων Χρονικών Συντακτική Επιτροπή
Published: December 2021

Περιεχόμενα τεύχους 53-54
Φιλάρετος Απ. Βιτάλης
Authors: Επιτροπή Συντακτική
Published: December 2021

Αφιέρωμα στον Φιλάρετο Απ. Βιτάλη (1929-2012)
Βιωματικές μαρτυρίες από το αλβανικό μέτωπο του 1940 και της γερμανικής κατοχής στην περιοχή της Λάκκας Λελόβου
Authors: Δήμα Αντιγόνη-Ιωάννα Δημήτριος
Published: December 2021

Σκοπός της παρούσας έρευνας είναι να καταγραφεί η ιστορία του τόπουκαταγωγής μου, το Θεσπρωτικό Πρεβέζης, την περίοδο του 1940-1944, μεαρωγό της προσπάθειάς μου αυτής την προφορική ιστορία. Κατάγομαι απόένα μέρος με μεγάλο ιστορικό ενδιαφέρον, από τη «Μικρή Λάκκα Σουλίου»ή αλλιώς «Λάκκα Λελόβου». Η Μικρή Λάκκα Σουλίου αποτελείται από ένα σύμπλεγμα χωριών (Κρανιά, Τύρια, Ριζοβούνι, Γαλατά, Ζερβό, Παπαδάτες, Μελιανά, Άσσος, Νικολίτσι, Ελιά, Πλατάνια, Ρωμιά) με κεφαλοχώρι το Θεσπρωτικό (με την παλιά ονομασία Λέλοβα). Η έρευνα περιέχει δεκαέξι προφορικές μαρτυρίες ανθρώπων που έζησαν πέμειναν τα σκληρά χρόνια της Κατοχής.
Το χαμάμ του Αλή πασά στην Πρέβεζα
Authors: Σαρρή Βασιλική Παρασκευάς , Σαρρή Ελισάβετ Παν.
Published: December 2021

Η έρευνα της ιστορίας και η μελέτη της αρχιτεκτονικής του οθωμανικού λουτρού του Αλή πασά στην Πρέβεζα αποτέλεσε μέρος της «Μελέτης Ανακαίνισης-Βελτίωσης του κτιρίου των Ιαματικών Λουτρών του Δήμου Πρέβεζας» που διεξήχθη το 2015 από το αρχιτεκτονικό γραφείο της Βασιλικής Σαρρή. Στο πλαίσιο της μελέτης κρίθηκε αναγκαία η σύνταξη ειδικής συμπληρωματικής μελέτης αποκατάστασης για τον οθωμανικό πυρήνα, ο οποίος βρίσκεται ενσωματωμένος στις εγκαταστάσεις τωνΙαματικών Λουτρών.Το αντικείμενο της μελέτης, ο οθωμανικός πυρήνας αναφερόμενο ως τοχαμάμ του Αλή πασά των Ιωαννίνων, αποτελεί ένα εξαίρετο δείγμα οθωμα-νικής αρχιτεκτονικής, η ίδρυση και η λειτουργία του οποίου είναι απόλυτασυνυφασμένη με την ιστορία της πόλης της Πρέβεζας.
Η οχύρωση του εξωτερικού περιβόλου του κάστρου του αγίου Αντρέα της Πρέβεζας και τα εντοιχισμένα σε αυτή λίθινα ανάγλυφα
Authors: Καράμπελας Νίκος Δ.
Published: December 2021

Το κυριότερο κάστρο της νεότερης Πρέβεζας, γνωστό μετά την απελευθέρωση της πόλης ως του αγίου Αντρέα, κατασκευάστηκε αρχικά από τους Οθωμανούς το 1702, έναν χρόνο μετά την παράδοση της Πρέβεζας σε αυτούς, από τους Βενετούς, κατά τα οριζόμενα από τη συνθήκη του Κάρλοβιτς και άλλες διμερείς συμφωνίες.Δεκαπέντε χρόνια αργότερα, τον Οκτώβριο του 1717, η Πρέβεζα θα καταλαμβανόταν για δεύτερη φορά από τις βενετικές δυνάμεις. Στα πρώτα χρόνια αυτής της βενετικής κυριαρχίας της πόλης (1718-1797), το κάστρο βελτιώθηκε αμυντικά και η έκτασή του μειώθηκε στη μισή, περίπου, της αρχικής.Μετά τη δεύτερη κατάληψη της Πρέβεζας από τον Αλή πασά Τεπελενλή, τον Νοέμβριο του 1806, ξεκίνησε μια νέα βελτίωση του κάστρου και κατασκευή ενός εξωτερικού περιβόλου, στον οποίο θα αναθερθούμε στο άρθαο.
Αρχείο Μητροπολιτικού Ιερού Ναού Αγίου Χαραλάμπους και Αρχείο οικογένειας Κουκότη
Authors: Κουμπέτσος Νίκος
Published: December 2021

Το παρόν άρθρο αποτελεί διασκευασμένη εκδοχή δύο δικτυακών δημοσιεύσεων του συλλέκτη κ. Νίκου Κουμπέτσου, με τις οποίες περιέγραφε το ιστορικό της εύρεσης του συγκεκριμένου αρχείου και παρουσίαζε το περιεχόμενό του. Τα δημοσιεύματα εντοπίστηκαν από τα ΓΑΚ – Αρχεία Ν. Πρέβεζας, στο πλαίσιο μιας διαρκούς αναζήτησης πληροφοριών για την ύπαρξη αρχείων που αφορούν στην περιοχή μας.
Ψαλτικές μορφές της Πρέβεζας
Authors: Θάνος Νεκτάριος Ν.
Published: December 2021

Γεγονός είναι πως η ψαλτική και οι θεράποντές της, οι ψάλτες, αποτελούν σημαντική, μάλλον καθοριστική συνιστώσα της λειτουργικής και αισθητικής ευπρέπειας των εκκλησιαστικών ακολουθιών, αφού με τη φωνή και τη μουσική τους κατάρτιση είναι σε θέση να οικοδομήσουν –αλλά δυστυχώς και να αποδομήσουν– τη λειτουργική σύναξη. Από την άποψη αυτή είναι κοινό και επιτακτικό χρέος όλων η ευγνωμοσύνη προς όσους ψάλτες δημιουργούν με το μουσικό τους ύφος και ήθος τις προϋποθέσεις που βοηθούν τον πιστό να συμμετέχει απερίσπαστος στα λειτουργικά δρώμενα της Εκκλησίας.
Η παράσταση της πολιορκίας της Πρέβεζας και της Βόνιτσας από τον στρατάρχη von der Schulenburg
Authors: Καρκαζής Μίλτος
Published: December 2021

Μετά την επιτυχημένη άμυνα του κάστρου της Κέρκυρας το 1716, ο στρατάρχης Johann Matthias von der Schulenburg (1661-1747), αρχηγός των βενετσιάνικων μισθοφορικών στρατευμάτων, αντεπιτέθηκε στις παράκτιες τουρκικές θέσεις. Στα 1717 προσέγγισε τα κάστρα της Πρέβεζας και της Βόνιτσας.
Σκέψεις με αφορμή μια φωτογράφιση στο κάστρο του Παντοκράτορα της Πρέβεζας
Authors: Βλασσάς Γρηγόρης
Published: December 2021

Ένα φωτογραφικό δοκίμιο για την καλλιτεχνική φωτογραφία, με αφορμή μια φωτογράφιση στο κάστρο του Παντοκράτορα στην Πρέβεζα.
Το κρυφτό; Του έρωτα και της ντροπής
Authors: Μπότσιος Βασίλειος
Published: December 2021

Ποιήματα
Στέφανου Σταμάτη, Χάρτινοι μύθοι , Διηγήματα
Authors: Παπακώστας Γιάννης
Published: December 2021

Βιβλιοκριτική
Θωμόκαστρο ή κάστρο της Ρινιάσας (τέλη 13ου - μέσα 15ου αιώνα)
Authors: Κουτσοτόλη Χρυσοβαλάντω
Published: December 2021

Η παρούσα εργασία πραγματοποιήθηκε κατά τη διάρκεια των μεταπτυχιακών μου σπουδών και συγκεκριμένα στο πλαίσιο του σεμιναριακού μαθήματος «Βυζαντινά κάστρα» και για την εκπόνηση της αξιοποιήθηκε υλικό που βρίσκεται στα σπουδαστήρια του Πανεπιστημίου Ιωαννίνων, καθώς επίσης στην Εταιρεία Ηπειρωτικών Μελετών.
Ιταλικά σχολεία στην Πρέβεζα: 1890-1940
Authors: Καινούργιος Ευάγγελος
Published: December 2021

Στα συμπεράσματα προηγούμενης εργασίας μου για τα ΠρεβεζάνικαΧρονικά με θέμα την ξενόγλωσση εκπαίδευση στην Πρέβεζα του Μεσο-πολέμου, σημείωνα την ανάγκη μιας διεξοδικότερης διερεύνησης τηςπερίπτωσης του ιταλικού σχολείου και ειδικότερα στα αρχεία του ΥπουργείουΕξωτερικών. Δύο χρόνια αργότερα ανακάλυψα ότι η έρευνα αυτή, όχι μόνογια την Πρέβεζα αλλά για το σύνολο των ιταλικών σχολείων στην Ελλάδα,έγινε από τον Δαυίδ Αντωνίου, ο οποίος, μάλιστα, έκανε και μια παραπομπήστα φτωχά αποτελέσματα της δικής μου εργασίας, στο βιβλίο του Ιταλικάσχολεία στην Ελλάδα.Με βάση αυτά τα νέα δεδομένα συνέχισα την προσπάθειά μου αξιοποιώ-ντας και αυτήν τη φορά προφορικές αλλά και εικονογραφικές πηγές, που μαςπαρέχουν σημαντικές πληροφορίες για την εκπαίδευση της ιταλικής κοινότη-τας της Πρέβεζας κατά το παρελθόν. Το υλικό αυτό το συνέλλεξα χάρη στηβοήθεια των αγαπητών φίλων Δημήτρη Μπέτσου και Κατερίνας Σισμανίδη, οιοποίοι με έφεραν σε επαφή με την κ. Βασιλική Σισμανίδη, παλιά μαθήτριατου ιταλικού δημοτικού σχολείου της Πρέβεζας. Τους ευχαριστώ θερμά όλουςγια τη βοήθειά τους.
Ποιο περιβάλλον; Ποια ανάπτυξη; Ποια διαχείριση;
Authors: Γιαννούλης Νικόλαος Δ.
Published: December 2021

Δεν αναφέρεται περίληψη
Το τρίγωνο των πατρίδων και η υπέρβαση τους: Γιάννης Δάλλας, «Περίακτος»
Authors: Μαφρέδας Στέλιος
Published: December 2021

Βιβλιοκριτική για το βιβλίο του Γιάννη Δάλλα "Περίακτος"
Επέτειοι στην άλω της χρονιάς της απελευθέρωσης: Πριν και μετά, τότε και τώρα
Authors: Ρέντζος Γιάννης
Published: December 2021

Ανασκόπηση της ιστορίας της απελευθέρωσης της πόλης και οι εορτασμοί της των επετείων
Οδυσσέας Θ. Μπέτσος (1930-2011) Σύντομο βιογραφικό και επιλογή εργογραφίας
Authors: Stork Michael
Published: December 2021

Δεν αναφέρεται περίληψη
Η έκθεση του ταγματάρχη Δημητρίου Ν. Δούλη για τη μάχη της Νικοπόλεως, 20.10.1912
Authors: Καράμπελας Νίκος Δ.
Published: December 2021

Παρουσίαση της εκθέσεως του Δημητρίου Ν. Δούλη για τη μάχη της Νικοπόλεως
Ο πανηγυρικός λόγος του μητροπολίτη Ιωακείμ και αφηγήσεις Πρεβεζάνων που βίωσαν την απελευθέρωση
Authors: Συνέσιος Λάζαρος Στ.
Published: December 2021

Ιστορικά γεγονότα από την ημέρα της απελευθέρωσης της Πρέβεζας από μαρτυρίες των κατοίκων και ο πανηγυρικός λόγος του μητροπολίτη Ιωακείμ
O αρχαιολογικός χώρος της Νικόπολης μετά την απελευθέρωση της Πρέβεζας (1913-1967)
Authors: Κωνσταντάκη Αθηνά Ι.
Published: December 2021

Παρουσίαση του αρχαιολογικού έργου της Νικόπολης από την απελευθέρωση της πόλης μεχρι και τη σύγχρονη εποχή και η  πολυεπίπεδη λειτουργία του αρχαιολογικού της χώρου.
Perception on Online Teaching and Learning Among Health Sciences Students in Higher Education Institutions during the COVID-19 Lockdown – Ways to Improve Teaching and Learning in Saudi Colleges and Universities
Authors: Aziz Ansari Khalid , Farooqi Faraz A. , Qadir Khan Soban , Alhareky Muhanad , C. Trinidad Ma. Abigail , Abidi Taha , M Muzaheed
Published: December 2021

Background: Online learning or E-learning are approaches to broadcasting teaching by the means of internet technology and software applications. Kingdom of Saudi Arabia is likewise embarking on the rapid growth in online education. The purpose of this study is to investigate the student’s perceptions regarding online teaching and learning during COVID 19.

Methods: An online computer-based cross-sectional study was conducted between May and June 2020. A pre-validated questionnaire was used and administrated to health sciences students studying at Dammam Universities through online software QuestionPro.

Results: Out of total 281, 68% of the participants were females (n=188) while 31.9% (n=88) were male students with an average age of 23.1(4.5) years. Overall, 176 (62%) of the students expressed their satisfaction with online learning.

Conclusion: Findings will help academicians to identify strengths, areas of improvement, and encourage faculty to think deeply to restructure course learning objectives, teaching techniques to engage students and improve learning process.