bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of the Orthodox Church in Montenegro in the establishment and unification of the Serbian Orthodox Church (1918–1922)
Authors:   University of East Sarajevo, Stamatović Aleksandar
Published: June 2023

The intention of this article is to show how the church life of the Orthodox Church in Montenegro went from the abolition of the Patriarchate of Peć (Serbian Church) in 1766, to the end of the process of establishment and unification of the same Church in the period from 1918 to 1922. The Patriarchate of Peć was abolished in 1766 by a decree of the Ottoman Sultan Mustafa III, violently and uncanonically. The Orthodox Church in Montenegro did not recognize that act, but continued its internal life, considering itself the successor of the Patriarchate of Peć. During the 19th century, there was state emancipation in Serbia as well as canonical emancipation in various ways of other Serbian dioceses. Finally, with the end of the First World War, in 1918, the conditions were created for the establishment and unification of the Serbian Church. The Church clergy in Montenegro largely supported the unification as a political act, and the process of the establishment and unification of the Serbian Church that means the return to the situation from 1766, in its entirety. All the hierarchs of the Holy Synod of the Orthodox Church in Montenegro supported this procedure, and led by the head of the Church, Metropolitan Mitrofan Ban, participated in it.
Constructing art history: Contemporary curatorial strategies in studying symbolism of the Baltic states
Authors:   Russian State University for the Humanities, Klyushina Elena Vitalievna
Published: June 2023

The article is devoted to the analysis of curatorial strategies used in the international exhibition «Wild Souls. Symbolism in the Baltic States», successfully implemented under the supervision of Rodolphe Rapetti in 2018–2021 in Paris, Tallinn, Vilnus and Riga. Revealing the originality of the curatorial narrative contributes to the identification of current research directions in the study of the Baltic countries visual culture of the 19th–20th centuries. The implemented project has the potential for further revision of generally accepted ideas about the genesis and development of the symbolist art in Estonia, Latvia and Lithuania. This also contributes to the formation and widespread dissemination of methodological approaches that have not been previously used in the art studies of these countries. To understand the novelty of the chosen strategies, historiographical analysis of art in the Baltic countries from the 1940s to the 1980s is carried out. The third conference of art historians of the Baltic republics in 1990 was called a turning point in the history of cultural studies. It is at this scientific event that Boris Bershtein calls for a metaposition and the usage of metalanguage in the construction of an «internal» description of national culture. According to the author of this article, an exhibition «Wild Souls» is intended to become such a metaposition, capable of summarizing the already accumulated knowledge and offering a new look at the development of visual culture. Using universal approaches to the study of symbolism, Rodolphe Rapetti, together with colleagues from Baltic museums, demonstrates the trans-regional community of artistic phenomena that took place in these countries, and also convincingly proves the involvement of the Baltic artists in the general European artistic process at the turn of the 19th and 20th centuries.
Spiritual principles of creativity: Personalistic aspect
Authors:   North-Caucasus Federal University, Lagunov Aleksey A. , Smirnov Andrey Yu. ,   North-Caucasus Federal University
Published: June 2023

The article attempts to interpret the concept of the spiritual through the use of personalistic methodological approach. Spiritual phenomena are considered in this case in comparison with the concept of creativity. It is argued that in the context of the Christian worldview, there is a clear connection between creativity and spiritual phenomena. Spirituality, being an a priori quality of any personality, can be understood both as a source, and as a mover, and as a result of its creative activity. The ideas about “positive” spirituality (correlated with the synergy of God and man), and about “negative” spirituality (correlating with “the arbitrariness” of godless personalities), the opposite nature of which is manifested in the difference between the products of human creative activity, are analyzed. Attention is focused on the fact that today spiritual and moral issues are often realized by us either poorly or not at all, which is caused by the blurring of the concept of the spiritual and the oblivion of the simplest truth, according to which morality, in order to avoid relativization, must have a solid religious philosophical foundation. The authors come to the conclusion that modern people’s unawareness of their own cognitive limitations, multiplied by diligently cultivated immoderate pride, does not allow them to adequately compare their total intelligence and spiritual and creative potential with the extensive spiritual experience of the most worthy representatives of the past, therefore, today it becomes necessary to renew Christian apologetics and widespread religious education.
Spatial estimation of soil erosion risk using RUSLE model in District Swat, Eastern Hindu Kush, Pakistan
Authors: Khan Abdullah , Rahman Atta-ur , Mahmood Shakeel
Published: June 2023

Soil erosion is a natural geomorphic process with the potential to damage fertile land. In this study, soil erosion risk is spatially estimated in District Swat by applying Revised Universal Soil Loss Equation (RUSLE). The RUSLE parameters that trigger soil erosion including rainfall erosivity, soil erodibility, topography, cover management, and support practices were derived from monthly rainfall data obtained from Pakistan Metrology Department, soil texture map from Soil Survey of Pakistan and Digital Soil Map of the World database, land use land cover extracted from SPOT 5 satellite image, whereas slope and digital terrain extracted from Shuttle Radar Topographic Mission (SRTM) Digital Elevation Model (DEM). It was found from the analysis that out of the total reported area, 34.5% falls in the area affected by very high soil erosion. The results of spatial pattern and erosion proneness of the study region have been further classified into very low (45%), low (8.5%), moderate (7%), high (5.2%), and very high zones (34.5%). The results show that the study area requires effective mitigation strategies to curtail the precious soil. This study has the potential to assist the decision makers and planners for soil loss risk reduction.
Impact of historical and future land use land cover on spatial-temporal variation of discharge and sediment load of Upper Tapi Basin, India
Authors: Malani Urvashi , Yadav SanjayKumar M.
Published: June 2023

Trend detection of discharge and sediment load is vital to adopt suitable conservation measures as per the changes occurring. In the present study, trends of daily streamflow and sediment load for Upper Tapi Basin are analyzed using Mann-Kendall, modified Mann-Kendall, and innovative trend analysis and change points are found using Pettitt tests from 1985 to 2020 to determine time series' trend with the statistical significance. Land use land cover (LULC) for Upper Tapi Basin is prepared for three decades (1989–2020). Innovative trend analysis has shown non-monotonicity in the time series with a decreasing trend. The streamflow is found to be significantly decreasing in the basin. A decline in sediment load is observed in Burhanpur and Gopalkheda while there is an increasing trend in Yerli G.S. The rise in anthropogenic activities is the main reason behind the reduction in suspended sediment load (SSL) over the basin. The decadal analysis of LULC showed an increase in built-up area (18.3%), barren land (5–8%), waterbodies (1.2–1.9%) agricultural land (50–60.79%) and a decrease in vegetation (from 43 to 21%). The LULC for 2030 is predicted with Land Change Modeler (LCM) in IDRISI Terrset. The estimated LULC shows that the built-up area will expand as agricultural land decreases. The overall study indicates that anthropogenic activities will increase in the future. The findings of this study will aid in decision making for river basin water resource management, as well as understanding the influence of human-caused activities on flow and sediment load variance.
Nanotechnology as an efficient and effective alternative for wastewater treatment: an overview
Authors: Pérez Heilyn , Quintero García Omar Jasiel , Amezcua-Allieri Myriam Adela , Rodríguez Vázquez Refugio
Published: June 2023

The increase in the surface and groundwater contamination due to global population growth, industrialization, proliferation of pathogens, emerging pollutants, heavy metals, and scarcity of drinking water represents a critical problem. Because of this problem, particular emphasis will be placed on wastewater recycling. Conventional wastewater treatment methods may be limited due to high investment costs or, in some cases, poor treatment efficiency. To address these issues, it is necessary to continuously evaluate novel technologies that complement and improve these traditional wastewater treatment processes. In this regard, technologies based on nanomaterials are also being studied. These technologies improve wastewater management and constitute one of the main focuses of nanotechnology. The following review describes wastewater's primary biological, organic, and inorganic contaminants. Subsequently, it focuses on the potential of different nanomaterials (metal oxides, carbon-based nanomaterials, cellulose-based nanomaterials), membrane, and nanobioremediation processes for wastewater treatment. The above is evident from the review of various publications. However, nanomaterials’ cost, toxicity, and biodegradability need to be addressed before their commercial distribution and scale-up. The development of nanomaterials and nanoproducts must be sustainable and safe throughout the nanoproduct life cycle to meet the requirements of the circular economy.
PaSTe. Blockade of the Lipid Phenotype of Prostate Cancer as
Metabolic Therapy: A Theoretical Proposal
Authors: Romo-Perez Adriana , Domínguez-Gómez Guadalupe , Chávez-Blanco Alma D. , González-Fierro Aurora , Correa-Basurto José , Dueñas-González Alfonso
Published: June 2023

Background:

Prostate cancer is the most frequently diagnosed malignancy in
112 countries and is the leading cause of death in eighteen. In addition to continuing research
on prevention and early diagnosis, improving treatments and making them more
affordable is imperative. In this sense, the therapeutic repurposing of low-cost and widely
available drugs could reduce global mortality from this disease. The malignant
metabolic phenotype is becoming increasingly important due to its therapeutic implications.
Cancer generally is characterized by hyperactivation of glycolysis, glutaminolysis,
and fatty acid synthesis. However, prostate cancer is particularly lipidic; it exhibits increased
activity in the pathways for synthesizing fatty acids, cholesterol, and fatty acid
oxidation (FAO).

Objective:

Based on a literature review, we propose the PaSTe regimen (Pantoprazole,
Simvastatin, Trimetazidine) as a metabolic therapy for prostate cancer. Pantoprazole and
simvastatin inhibit the enzymes fatty acid synthase (FASN) and 3-hydroxy-3-methylglutaryl-
coenzyme A reductase (HMGCR), therefore, blocking the synthesis of fatty acids
and cholesterol, respectively. In contrast, trimetazidine inhibits the enzyme 3-β-Ketoacyl-
CoA thiolase (3-KAT), an enzyme that catalyzes the oxidation of fatty acids (FAO).
It is known that the pharmacological or genetic depletion of any of these enzymes has antitumor
effects in prostatic cancer.

Results:

Based on this information, we hypothesize that the PaSTe regimen will have increased
antitumor effects and may impede the metabolic reprogramming shift. Existing
knowledge shows that enzyme inhibition occurs at molar concentrations achieved in plasma
at standard doses of these drugs.

Conclusion:

We conclude that this regimen deserves to be preclinically evaluated because
of its clinical potential for the treatment of prostate cancer.
CENPF Upregulation is Associated with Immunosuppressive Status and Poor Clinical Outcomes in Lung Adenocarcinoma Validated by qRT-PCR
Authors: Xu Zhiyun , Xu Dafu , You Zhenbing , Tian Wenze
Published: June 2023

Objective:

CENPF-differentially expressed in various types of cancers—is a marker of
poor prognosis. However, studies on the impact of CENPF on patient prognosis in lung adenocarcinoma
regarding immune infiltration are lacking.

Methods:

CENPF expression profiles were analyzed in the GEO and TCGA databases. qRT-PCR
was used to verify CENPF mRNA expression in lung adenocarcinoma cell lines. The prognostic
value of CENPF was evaluated by combining data from clinical samples in the GEPIA2 and
TCGA databases. Metascape and WebGestalt were used for enrichment analysis of gene sets most
positively associated with CENPF. Immune cell infiltration score data were retrieved from TCGA
and the correlation between CENPF expression and immune cell infiltration was analyzed.

Results:

CENPF expression was elevated in 29 types of cancer. CENPF was highly expressed and
increased with tumor grade in lung adenocarcinoma. Immunohistochemical and qRT-PCR analyses
revealed that CENPF expression was upregulated in lung adenocarcinoma tissues and cells. High expression
of CENPF significantly worsened prognoses in patients with multiple malignancies, including
lung adenocarcinoma. Results from gene set enrichment analysis indicated significant enrichment
of the progesterone-mediated oocyte maturation pathway. Immune infiltration analysis revealed that
CD4+ Th2 cell infiltration was significantly higher in the high CENPF expression group.

Conclusion:

Upregulation of CENPF expression was related to poor progression-free survival, disease-
free survival, and overall survival in patients with lung adenocarcinoma. High expression of
CENPF was markedly related to genes associated with the immune checkpoint. Lung adenocarcinoma
samples with high CENPF expression had increased CD4+ Th2 cell infiltration. Our findings
indicate that CENPF promotes CD4+ Th2 cell infiltration through oncogenic activity and may be
used as a biomarker for predicting patient outcomes in lung adenocarcinoma.
Literature Review on Crotalus durissus terrificus Toxins: From a Perspective
of Structural Biology and Therapeutic Applications
Authors: Macedo Jamile Mariano , de Lima Anderson Maciel , Kayano Anderson Makoto , Souza Mateus Farias , da Silva Oliveira Iolanda , Gomez Garay Ana Fidelina , Rocha Anderson Maciel , Zuliani Juliana Pavan , Soares Andreimar Martins
Published: June 2023

Background:

The venom of Crotalus durissus terrificus, as well as its fractions, has intrigued
research groups worldwide who are working to isolate, characterize, and find possible biotechnological
applications. A number of studies have elucidated that these fractions and their derivatives
possess pharmacological properties, which can enable the development of new drug prototypes with
anti-inflammatory, antinociceptive, antitumor, antiviral, and antiparasitic applications.

Objective:

This review presents a systematic study on Crotalus durissus terrificus, the most notable
crotalid subspecies in South America, focusing on the composition, toxicological mechanisms, structural
aspects, and applications of the main venom toxins (convulxin, gyroxin, crotamine, crotoxin, and
their subunits).

Conclusion:

The authors have found that research on this snake and its toxins is still an area of focus,
despite that almost a century has passed since the isolation of crotoxin. Several applications of these
proteins in the development of novel drugs and bioactive substances have also been demonstrated.
Establishment of a Rat Model of Infraorbital Neuroinflammation Under
CT Guidance
Authors: Zeng Chen , Zhang Chuan , Xiao Ruhui , Li Yehan , Luo Xing , Deng Hao , Yang Hanfeng
Published: June 2023

Introduction:

The aim is to establish a rat model of infraorbital neuroinflammation with
less trauma, stable pain, and a long duration of pain. The pathogenesis of TN is not fully clear.
There are various models of TN in rats with different disadvantages, such as damaging the surrounding
structures and inaccuracy of location for infraorbital nerve (ION). We aim to establish a
rat model of infraorbital neuroinflammation with minimal trauma, a simple operation, and accurate
positioning under CT guidance to help us study the pathogenesis of trigeminal neuralgia.

Methods:

Thirty-six adult male Sprague Dawley rats (180-220 g) were randomly divided into 2
groups and injected with talc suspension or saline through the infraorbital foramen (IOF) under CT
guidance. Mechanical thresholds were measured in the right ION innervation region of 24 rats over
12 postoperative weeks. At 4 weeks, 8 weeks, and 12 weeks after the operation, the inflammatory
involvement of the surgical area was evaluated by MRI, and neuropathy was observed using a
transmission electron microscope (TEM).

Results:

The talc group had a significant decrease in the mechanical threshold at 3 days after surgery
that continued until 12 weeks post-operation, and the talc group had a significantly lower mechanical
threshold than the saline group 10 weeks post-operation. The talc group had significantly
impaired trigeminal nerve (TGN) myelin after 8 weeks post-operation.

Conclusions:

The rat model of infraorbital neuroinflammation established by CT-guided injection
of talc into the IOF is a simple operation that results in less trauma, stable pain, and a long duration
of pain. Moreover, infraorbital neuroinflammation in peripheral branches of the TGN can cause
demyelination of the TGN in the intracranial segment.
Female Sexual Function following Pelvic Organ Prolapse Reconstruction:
A Case Serial Study
Authors: Rahayu Sri , Fakhrizal Edy , Yulis Hamidy Muhammad
Published: June 2023

Background:

Pelvic organ prolapse (POP) may reduce women's quality of life and is one of the most important aspects in the occurrence of sexual dysfunction.

Objective:

This study aimed to assess sexual function in POP women with pelvic floor dysfunction pre and post-surgery.

Methods:

This study was a prospective cohort study. Using the total sampling technique at Arifin Achmad Hospital, Indonesia, the study recruited women who underwent POP surgery with active sexual function from July 2020 to December 2021. The pelvic floor disorder was evaluated through Pelvic Floor Distress Inventory (PFDI) questionnaires validated in the Indonesian language, pre, and post-surgery. The assessment of sexual function was carried out using the Indonesian linguistic validation of the Female Sexual Function Index (FSFI) questionnaires before and after surgery.

Results:

There was a decrease in the average value of pelvic floor disorder scores before and six months after surgery (P< 0.05). However, the sexual function increased with a cut-off score of FSFI > 20.25 at 3 and 6 months post-surgery, respectively as much as 61.1% (11/18 subjects) and 72.2% (13/18 subjects), compared to the pre-surgery sexual function scores by 7.8% (5/18 subjects). Out of the 6 domains of sexual function, an increase was found in the sexual arousal domain (P<0.05).

Conclusion:

There is a decrease in pelvic floor disorder and an increase in sexual function, particularly an increment in sexual arousal at six months post-surgery.
Phytochemistry and Biological Assessment of Thuja articulata Trunk Barks:
HPLC-PDA-ESI-MS Analysis, Bioevaluation, and Molecular Docking
Authors: Algethami Faisal K. , Jlizi Salma , Znati Mansour , Elamin Mohamed R. , Ben Hamadi Naoufel , Ben Jannet Hichem
Published: June 2023

Background:

Thuja articulata is a Mediterranean forest species from the Cupressaceae family, it has been used in popular medicine to treat several diseases. Various studies have been carried out in vitro using diverse T. articulata extracts to understand its traditional use.

Methods:

In this study, the ethyl acetate extract of T. articulata trunk barks was chemically identified
using HPLC-PDA-ESI-MS, then examined in vitro for its antioxidant and α-amylase inhibitory
effects. A molecular docking study was also performed to reinforce the noted bioactivities.

Results:

HPLC-PDA-ESI-MS analysis led to the identification of 22 polyphenolic compounds
in the ethyl acetate extract of T. articulata trunk barks. This extract revealed interesting in vitro
antioxidant properties and a significant α-amylase inhibitory action (IC50 = 16.08 ± 1.27 μg/mL).
In silico analysis was found to agree with the in vitro studies in which major constituents of the
ethyl acetate extract revealed low binding energy and a correct mode of interaction in the active
pocket of the enzyme (PDB: 7TAA). The anti-a-amylase potential could be due either to a synergistic
or individual action of certain constituents present in this extract.

Conclusion:

This study illustrates that the ethyl acetate extract of T. articulata trunk barks has
potent sources of antioxidants and α-amylase inhibitors to be explored.
In silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of
BRAF and NRAS in Controlling Thyroid Cancer
Authors: Alamri Ahmad M. , Alkhilaiwi Faris A. , Khan Najeeb U. , Tasleem Munazzah
Published: June 2023

Background:

Thyroid carcinoma (THCA) is one of the most prevalent endocrine tumors, accounting for
3.4% of all cancers diagnosed annually. Single Nucleotide Polymorphisms (SNPs) are the most prevalent genetic variation
associated with thyroid cancer. Understanding thyroid cancer genetics will enhance diagnosis, prognosis, and
treatment.

Methods:

This TCGA-based study analyzes thyroid cancer-associated highly mutated genes through highly robust in
silico techniques. Pathway, gene expression, and survival studies were performed on the top 10 highly mutated genes
(BRAF, NRAS, TG, TTN, HRAS, MUC16, ZFHX3, CSMD2, EIFIAX, SPTA1). Novel natural compounds from
Achyranthes aspera Linn were discovered to target two highly mutated genes. The natural compounds and synthetic
drugs used to treat thyroid cancer were subjected to comparative molecular docking against BRAF and NRAS targets.
The ADME characteristics of Achyranthes aspera Linn compounds were also investigated

Results:

The gene expression analysis revealed that the expression of ZFHX3, MCU16, EIF1AX, HRAS, and NRAS was
up-regulated in tumor cells while BRAF, TTN, TG, CSMD2, and SPTA1 were down-regulated in tumor cells. In addition,
the protein-protein interaction network demonstrated that HRAS, BRAF, NRAS, SPTA1, and TG proteins have
strong interactions with each other as compared to other genes. The ADMET analysis shows that seven compounds
have druglike properties. These compounds were further studied for molecular docking studies. The compounds
MPHY012847, IMPHY005295, and IMPHY000939 show higher binding affinity with BRAF than pimasertib. In addition,
IMPHY000939, IMPHY000303, IMPHY012847, and IMPHY005295 showed a better binding affinity with
NRAS than Guanosine Triphosphate.

Conclusion:

The outcomes of docking experiments conducted on BRAF and NRAS provide insight into natural compounds with pharmacological characteristics. These findings indicate that natural compounds derived from plants as a more promising cancer treatment option. Thus, the results of docking investigations conducted on BRAF and NRAS substantiate the conclusions that the molecule possesses the most suited drug-like qualities. Compared to other compounds, natural compounds are superior, and they are also druggable. This demonstrates that natural plant compounds can be an excellent source of potential anti-cancer agents. The preclinical research will pave the road for a possible anti-cancer agent.
Civic values: Thematic studies on citizenship in Islam
Authors: Muchtarom Moh. , Selamat Abu Zarrin Bin
Published: June 2023

Indonesia's diverse religious, tribal, cultural, and linguistic background has resulted in frequent disputes between different groups due to the lack of firmly established civic values. As the majority population, Islamic ummah holds a vital role in establishing and managing a peaceful, fair, and prosperous society. The Qur’an, being the primary source of Islamic law, contains principles and meanings of social values that laid the foundation of the first Islamic country in Medina. Therefore, it is essential for followers of Islam to explore civic values in the Qur’an that can be integrated into Indonesian civic values. However, previous research on the concept of the ummah in the Qur’an that can construct civic values is lacking. This study aimed to address this gap by conducting qualitative research through a library research method and thematic analysis. The study identified civic values in the Qur’an that included unity, self-regulation, justice, honesty, responsibility, moderation, tolerance, rule of law, purity, change, plurality, critical thinking, and becoming a participatory, humanist, emancipatory, liberal society inseparable from the transcendental path. Integrating these values into Indonesian civic values can contribute to establishing a peaceful, fair, and prosperous society that values diversity, justice, and the rule of law.
Land pawning practice in Semoyo Village, Patuk Sub-District, Gunungkidul Regency
Authors: Widihastuti Setiati , Choirunnisa Mita
Published: June 2023

This study utilizes a qualitative approach to examine the customary practice of land pawning in Semoyo Village. This practice is based on traditional institutions passed down for generations. It involves the direct transfer of land without the need for a written agreement, witnesses, or village officials. The spirit of togetherness and trust in neighbors and relatives facilitate this practice. The borrower surrenders possession of the land to the lender, who can redeem the land within an agreed-upon time frame. In reality, land pawning has been a common practice in Semoyo Village for decades, as landowners have been unable to redeem their land. While the land is under pawn, the borrower has the right to possession and use. However, the land pawning practice in Semoyo Village is susceptible to disputes and coercion, despite being regulated by Article 7 of Law Number 56 PRP of 1960. Nonetheless, Semoyo Village residents continue to practice land pawning for various reasons, such as urgent needs, avoiding selling their land, difficulty obtaining loans from banks, mutual assistance, and obtaining additional cultivation land. Land pawning is only conducted among close neighbors or trusted relatives whose character is well-known.
Integrating democracy learning and prophetic social studies at Baitusalam Islamic School Yogyakarta
Authors: Nasiwan Nasiwan , Wulandari Taat , Wijayanti Agustina Tri
Published: June 2023

This paper describes an attempt to integrate Islamic and scientific values into social studies education with the aim of developing prophetic social science theory to explain social problems from this perspective. The study focuses on the implementation of this theory at Baitusalam Islamic School in Yogyakarta, using qualitative research methods such as observation, interviews, and documentation. The findings suggest that social studies learning  Islamic values that develop boarding power, with the learning process incorporating these values into planning, implementation, and assessment. However, the study also identifies challenges in the integration process, such as the lack of student textbook references that integrate values into Islamic language for each material, insufficient learning media, and inadequate infrastructure in schools. Overall, this study highlights the importance of integrating Islamic and scientific values into social studies education to develop young people's sense of nationalism, independence, and character, while acknowledging the need to address these challenges for effective implementation.
Teori Titik Tetap untuk Pemetaan (ψ,φ)_Ω-Kontraksi pada Ruang p-Metrik Modular Berorder
Authors: Hayati Afifah , Harini Lusi , Winarni Ambar , Muhassanah Nur'aini
Published: June 2023

Penelitian ini bertujuan untuk memberikan definisi pemetaan (psi,varphi)_omega-kontraksi dalam ruang p-metrik modular, memberikan teorema titik tetap untuk pemetaan (psi,varphi)_omega-kontraksi pada ruang p-metrik modular, dan memberikan aplikasi dari teorema titik tetap tersebut. Penelitian ini menggunakan metode studi literatur. Hasil penelitian menunjukkan bahwa pemetaan (psi,varphi)_omega-kontraksi didefinisikan dalam ruang -metrik modular dengan memperumum pemetaan (psi,varphi)_omega-kontraksi dalam ruang p-metrik dan teorema titik tetap untuk pemetaan tersebut pada ruang p-metrik modular yang juga merupakan perumuman dari teorema titik tetap tersebut pada ruang p-metrik dengan penambahan beberapa sifat yang diasumsikan. Selain itu, hasil penilitian lainnya adalah aplikasi teorema titik tetap tersebut yang menjamin eksistensi solusi suatu persamaan integral yang juga merupakan perumuman dari aplikasi teorema titik tetap tersebut dalam ruang p-metrik. Dari hasil tersebut, dapat disimpulkan bahwa pemetaan (psi,varphi)_omega-kontraksi dapat didefinisikan dalam ruang p-metrik modular dan dapat dibuktikan teorema titik tetap untuk pemetaan (psi,varphi)_omega-kontraksi pada ruang p-metrik modular beserta aplikasi dari teorema titik tetap tersebut yang menjamin eksistensi solusi suatu persamaan integral.
Short-range order in "disordered" aluminum solid solutions in α-iron
Authors: Ershov N. V.  , Kleinerman N. M.  , Lukshina V. A.  , Chernenkov Y. P.  , Shishkin D. A.  , Smirnov O. P.  , Semenov V. G.
Published: June 2023

The atomic structure of soft magnetic iron-aluminum alloys is studied by X-ray diffraction and nuclear gamma-resonance spectroscopy. The concentration dependence of the body-centered cubic lattice constant and the short-range order (SRO) parameters in the region of a disordered solid solution is monitored. It is shown that in the concentration range from 3 to 18 at.% Al, the lattice constant increases almost linearly. Discrete decomposition of nuclear gamma resonance spectra makes it possible to determine such SRO parameters as the relative fractions of contributions from coordinations without Al atoms and with one, two, and three Al atoms in the first and second coordination shells. The deviation of the values of these fractions from the average statistical probabilities indicates the presence of a chemical order in the arrangement of atoms. The largest deviations are observed at 12 and 15 at.% Al. Conditions of preliminary heat treatment, such as quenching from the paramagnetic state and holding in the ferromagnetic state, give very similar values of the SRO parameters. The method is characterized by a high resolution in the hyperfine field, while having a rather high sensitivity for determining the intensity of individual contributions Keywords: soft magnetic alloys, disordered Fe-Al solid solution, local ordering, X-ray diffraction, Mossbauer effect, distribution of atoms over coordination shells.
An increase in the critical current of superconducting composites upon implantation of iron ions
Authors: Rudnev I. A.  , Podlivaev A. I.  , Abin D. A.  , Pokrovskii S. V.  , Starikovskii A. S.  , Batulin R. G.  , Fedin P. A.  , Prianishnikov K. E.  , Kulevoy T. V.
Published: June 2023

The results of studying the effect of ion irradiation (Fe2+ E=5.6 MeV) in the modes of creating radiation defects and implantation on the critical current of high-temperature superconducting (HTS) composites are presented. An analysis was made of both the integral critical current obtained from measurements of the total magnetization of the samples and the local critical current determined from the data of scanning Hall magnetometry. It is shown that at the same ion fluence Phi=2·1013 cm-2, an increase in the critical current Jc is observed in the ion implantation regime, while in the regime of radiation defects, a slight drop in Jc is observed. This circumstance indicates an enhancement of pinning due to the additional magnetic interaction of Abrikosov vortices with magnetic ions implanted in the HTS layer. Keywords: high-temperature superconductor, irradiation, radiation defects, critical current, magnetization.
DEVELOPMENT OF HERBAL MOSQUITO-REPELLENT FORMULATIONS AND THEIR COMPARATIVE EVALUATION
Authors: PJ PRASUNA SUNDARI , SUSHMA CHATLA , SRIJA TOTA
Published: June 2023

Objective: The present research work aimed to develop herbal mosquito repellents as gels, incense sticks, and liquids for plug-in devices and also to assess their performance characteristics.
Methods: Herbal materials possessing mosquito-repellent activity were selected from the literature review based on percentage repellency and protection period. In this study, lavender, rosemary, lemongrass, and cedarwood oils were selected as actives. Span 20 and tween 80 were used to emulsify the volatile materials and then incorporated into Carbopol 934 base to form F1 and F2 gels which were evaluated for homogeneity, pH, spread ability, viscosity, and extrudability. Incense sticks were developed using charcoal and jigat as base materials. The prepared incense sticks F3 and F4 were evaluated for burning time, ash weight, and smoke. Solutions F5 and F6 were prepared using surfactants and cosolvents and were evaluated for phase separation. All formulations were screened for their mosquito repellency by screen cage method and their performance was compared to that of the marketed herbal repellents.
Results: Reared mosquitoes were identified as Culex species by microscopical observations of the antenna and maxillary palps. Mosquito repellency in 4 h is 93%, 87%, 89%, 79%, 89%, and 85% for F1, F2, F3, F4, F5 and F6, respectively. Among all, gel formulation F1 expressed the highest mosquito-repellent activity with 93% and is a better candidate.
Conclusions: Gel, incense sticks, and liquids prepared for use in plug-in devices exhibited reasonably good percentage repellency comparable to that of the standard. All the developed formulations are suitable for indoor protection from mosquito bites. However, safety, stability, and field studies need to be carried out to demonstrate suitability for regular use.
IRON PROFILE STATUS IN PSORIASIS PATIENTS AND THEIR CORRELATION WITH THE DEGREE OF SEVERITY OF DISEASE
Authors: RATHORE SHEETAL , R JAIN ANURADHA , KUMAR KAIN MANISH , PANDYA NITIN , SAXENA TRIPTI
Published: June 2023

Objectives: (1) The objective of the study was to evaluate and compare the levels of ferritin, iron, total iron binding capacity (TIBC), and hemoglobin (Hb) in cases and controls (2) and to correlate these parameters with the severity of psoriasis.
Methods: Iron-profile including serum ferritin, iron, TIBC, and Hb was evaluated in 100 subjects, 50 cases (psoriatic) and 50 controls (normal healthy individuals). A preformed pro forma was filled for each patient after taking written consent. Ferritin was evaluated using fully automated chemistry analyzer, iron, and TIBC were evaluated by semi-autoanalyzer and Hb by Automated Hematology Cell Counter.
Results: In our study, a lower level of serum ferritin, iron, and Hb was found in cases than controls, whereas the levels of TIBC were found higher in cases than controls. (p<0.05) We found a negative correlation of ferritin and a positive correlation of hemoglobin with psoriasis area and severity index.
Conclusion: We conclude that iron profile should be done early in the course of disease to improve dietary advices and treatment modalities.
FABRICATION AND RELEASE KINETICS OF PIPERAZINE CITRATE TABLETS USING NATURAL GUM
Authors: DAS SUDIPTA , BISWAS PINKI , DUTTA CHANDRIMA , BISWAS DIPTENDU SEKHAR
Published: June 2023

Objective: The objective of the present study was to formulate the piperazine citrate tablets using natural aloe vera gum as a binding agent and evaluate the tablets.
Methods: The extracted aloe vera gum was used for the preparation of piperazine citrate tablets, and the binding characteristics are compared with an equivalent amount of acacia and sodium carboxymethyl cellulose (NaCMC) in different formulations of piperazine citrate tablets. Three batches of piperazine citrate tablets were prepared using acacia (F1), NaCMC (F2), and aloe vera gum (F3) as binding agents. The assessment parameters that are used to evaluate the binding property were the hardness, friability, disintegration time, in vitro dissolution rate, and amount release study. The drug release kinetics of different formulations was determined.
Results: The granules were evaluated by determining the angle of repose (25.39±0.13 to 26.23°±0.11°), bulk density (0.567±0.004 to 0.596±0.006 g/cm3), tapped density (0.672±0.006 to 0.717±0.007 g/cm3), Hausner ratio (1.185±0.03 to 1.211±0.016), and Carr’s index (15.62±0.021 to 17.48%±0.009%), which shows a satisfactory flow ability. The tablets were subjected to hardness (3±0.63 to 4±0.82 kg/cm2), friability (0.57±0.01 to 0.75%±0.001% w/w), disintegration time (14.78±0.23 to 20.02±0.11 min), and in vitro release studies. The drug release kinetics of different formulations was determined.
Conclusion: As per the results, aloe vera gum has good binding properties and can be preferred over other binders and might be found to be a suitable binder in fast dissolving tablets formulation.
ANTIBIOTIC PROPHYLAXIS USE IN PATIENTS ADMITTED IN GENERAL SURGERY DEPARTMENT AT A TERTIARY CARE TEACHING HOSPITAL IN HARYANA
Authors: NARWAT ARVIND , SHARMA MAMTA , KHOSLA PREM PRAKASH
Published: June 2023

Objective: In India, due to a lack of adequate information and guidelines for antimicrobial prophylaxis in surgery, there is a need to generate baseline data on the pattern of the use of prophylactic antibiotics. Hence, we planned this study with an objective to study the antimicrobial prophylaxis use in the patients admitted to the general surgery department. Methods: The present study was a prospective observational study conducted in the department of pharmacology in collaboration with the department of surgery with the prior approval of the Institutional Ethical committee. All data were retrieved from the patients’ case records. Using a convenient sampling method, 100 adult patients who underwent surgical procedures in MMIMSR during the study period were taken. Results: A total of 100 patients admitted to the general surgery department of MMIMSR fulfilling the inclusion and exclusion criteria were enrolled. Out of 100 patients, 52 (52%) were male and 48 (48%) were female patients who underwent surgery and the majority of the patients enrolled are between 48 and 58 years (40%) of age. Cholecystectomy (28%) was the most frequent performed surgery type followed by hernial repair (24%) and hemorrhoidectomy (14%) Among all cases, surgical antibiotic prophylaxis was recommended in 93 (93%) patients. The most preferred route of administration of surgical antibiotic prophylaxis was parenteral route 100 (100%) and ceftriaxone was most commonly prophylactically prescribed antibiotic. Conclusion: Surgical site infection is the most common nosocomial infections in surgical patients accounting for prolonged hospital stay, mortality, and increased cost of care. According to the analyzed results of our study and from view of literature, the present study provides us patterns of antibiotic usage in patients admitted in surgery wards.
COMPARISON OF CYTOLOGICAL AND HISTOPATHOLOGICAL FINDINGS IN BREAST LESIONS – A TERTIARY CARE CENTER
Authors: Bharatkumar Patel Hani , Samanta Matariswa , Nikhra Pawan , Behl Vishakha , Ashvinbhai Patel Ujaskumar
Published: June 2023

Introduction: The objective of the study was to compare the findings of cytological and histopathological features of breast lesions.
Methods: This study conducted on 109 patients with breast lump with fine needle aspiration cytology (FNAC) followed by histopathology at Department of Pathology, Pacific Institute of Medical Sciences, Umarda, Udaipur, Rajasthan. The study duration is 18-month study period (April 2021 to September 2022).
Results: The mean age of the study subjects was 44.20 years with majority of the patients belonged to the age group 41–50 years (36.70%). Out of 109 cases, 84 cases (77.07%) were benign and 23 cases (21.10%) were malignant pathology in FNAC. Rest two cases had intermediate pathology. Majority of histopathological diagnosis of breast lumps in the present study were benign pathology (75.23%) and rest all malignant (24.77%).
Conclusion: Our study shows that FNAC can reliably distinguish between benign and malignant conditions and it is a sensitive and specific modality that assist in diagnosis and management of breast lesions. Although FNAC has been found to be a most valuable economic, simple, and safe diagnostic procedure, due to certain pitfall of FNAC like in case of pauci-cellularity blood mixed aspirates and blind technique procedure. Histopathological correlation is always mandatory for early diagnosis and better prognosis.
DIAGNOSTIC ROLE OF GALECTIN-3 EXPRESSION IN BENIGN FOLLICULAR PATTERNED THYROID LESIONS, NON-INVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP), AND INFILTRATIVE FOLLICULAR VARIANT PAPILLARY THYROID CARCINOMA (IFVPTC)
Authors: V Tamilselvi , Venugopal Lakshmy , Ravikumar Krishnan , Rajendran Divya
Published: June 2023

Objectives: The objective of the study was to determine the role of Galectin-3 expression in distinguishing Benign follicular patterned thyroid lesions, non- Invasive follicular thyroid neoplasm with papillary-like nuclear Features (NIFTP), and invasive follicular variant of papillary thyroid carcinoma (IFVPTC).
Methods: The Institutional Human Ethics Committee reference number is 271/pathology/09/2022. A total of 85 cases were included in the study after the histopathological evaluations based on strictly defined inclusion and exclusion criteria. Study groups were created as nodular hyperplasia, follicular adenoma, follicular carcinoma, NIFTP, invasive EFVPTCs, and classical papillary thyroid carcinomas. Cytoplasmic Galectin-3 Immunohistochemistry (IHC) expression was evaluated in these cases. Galectin-3 IHC scores data were analyzed using IBM SPSS statistics. The Chi-square test was used to determine the association between the variables. p<0.05 was considered statistically significant.
Results: Cytoplasmic galectin-3 IHC expression was significantly increased in malignant follicular patterned thyroid lesions compared to benign lesions with p<0.00001. Similarly, cytoplasmic galectin-3 IHC expression was significantly increased in IFVPTC when compared to NIFTP with a p-value of 0.01358. The Odds Ratio showed the positive cytoplasmic Galectin-3 expression in IFVPTC with a 7.5 times higher risk of having adverse outcome when compared to NIFTP.
Conclusion: Cytoplasmic Galectin-3 IHC expression may serve as a useful biomarker in predicting the invasiveness of FVPTC and distinguishing NIFTP from infiltrative FVPTC.
PULMONARY FUNCTION CHANGES IN SANITARY WORKERS OF KANCHIPURAM POPULATION
Authors: Pappaiya Muninathan , Vadivel Kamalakannan , Chelliah Selvakumar
Published: June 2023

Objectives: The main objective of this study is to evaluate the respiratory function of sanitary workers as they are most exposed to environmental air pollutants. Methods: The study was done among sanitary workers of Kanchipuram Municipality, Tamil Nadu, with 190 subjects, who were divided into two groups such as Group I and Group II. Group I with 96 sanitary workers and Group II with 94 as the control group with age- and morphometric-matched subjects. The subjects involved are both gender with the age group between 20 and 60 years. Various functional parameters, namely FVC, FEV1, FVC/ FEV1, FEF 25%, FEF50%, and FEF75%, were done using RMS Helios 3.1.37 in the Physiology Department, Meenakshi Medical College and Research Institute. Institutional Ethical Committee approval was obtained from Institutional Human Ethical Committee. Results: The pulmonary findings showed a significant decrease in FVC, FEV1, FVC/FEV1, FEF 25%, FEF50%, and FEF75% when compared to the control group. Conclusion: The sanitary workers showed a significant decrease in the pulmonary function tests as they were exposed to a variety of solid waste particles which might have caused inflammatory and immunological responses with the small and large airways of the respiratory tract.
CYTO-HISTOPATHOLOGICAL CORRELATION OF PREMALIGNANT AND MALIGNANT LESIONS OF THE ORAL CAVITY IN A TERTIARY CARE HOSPITAL
Authors: MEHER GHANASHYAM , HEMBRAM PABITRA , TUDU KSHETRA MOHAN , SAHU BINOD KUMAR
Published: June 2023

Objectives: Globally, oral cancer seems to be the sixth-utmost common cancer. Oral cancer is the chief among entire malignant tumors of men in the Indian subcontinent and squamous cell carcinoma is the commonest among all oral malignancies. Hence, in the present study, the utility of aspiration and scrape cytology in the screening and initial diagnosis of oral lesions, to confirm by histopathology, were studied.
Methods: The enrolled patients underwent complete clinical history, examination, fine-needle aspiration cytology (FNAC), scrape cytological assessment, and histopathological observations at VIMSAR, Odisha. Cytological smears were stained with Diff-Quik and Papanicolaou stains. Cytological observations were interrelated with concluding histopathological identification.
Results: There were 32 premalignant and 60 malignant lesions of the oral cavity. Overall 69.56% diagnostic accuracy of scrape cytology for numerous intraoral premalignant and malignant lesions was found. The most common site for premalignant lesions was in the buccal mucosa, and malignancy was the tongue. Among the malignant lesion, squamous cell carcinoma was major, constituting 86.66% of cases, and most of the patients were in the fifth decade. Risk factor, mostly tobacco exposure, was associated with 66.66% of cases of a malignant lesion.
Conclusion: FNAC and scrape cytology were observed as precise convenient, simple, and economical in the initial diagnosis of pre-cancerous and cancerous lesions of the oral cavity.
Maximizing the Potentials of the Internet in Enhancing the Conduct of Computer-Based Tests for University Admission in a South-West Nigerian University
Authors: Ojo Olayinka Anthony , Akpalaba Immaculata Ogechi , Olugbade Damola
Published: June 2023

The internet presents numerous opportunities for universities to reach a wide audience with timely and relevant information. This study examines the potential impact of the internet on reaching university admission candidates, identifying application challenges, and assessing the conduct of Post Unified Tertiary Matriculation Examination (Post-UTME) tests in a South-West Nigeria University. The population for the study comprised applicants who took the Post-UTME test at the Computer-Based Test (CBT) Centre, University of Medical Sciences, Ondo. The study utilized internet adverts and surveys to disseminate information and gather feedback from participants. Results showed that the majority of applicants were reached through internet digital adverts with no difficulties encountered during the application process. The university's Facebook page had the highest views and engagements from admission seekers. The conduct of the Post-UTME test was commended by most applicants. The study concluded that the Internet can facilitate increased participation and easy assessment of Post-UTME tests in the university. It recommends that universities should explore the potential benefits of internet adverts and surveys in disseminating admission-related information, extracting feedback from stakeholders, and sensitizing the public about university programs.
ТЕХНОЛОГИЯ СЕТЕВОГО ПОЗИЦИОНИРОВАНИЯ LTE. ЧАСТЬ 3. SDR-ДЕМОНСТРАТОР В ЛАБОРАТОРНЫХ УСЛОВИЯХ
Authors: Фокин Г.А. , Григорьев В.А. , Рютин К.Е.
Published: June 2023

Использование инфраструктуры базовых станций (eNB) сотовых сетей подвижной
радиосвязи LTE позволяет решить задачу определения местоположения
пользовательских устройств (UE) по опорным сигналам eNB гиперболическим
разностно-дальномерным методом независимо от ГНСС. Представленные в составе демонстратора макеты eNB и UE, построенные с использованием технологий
программно-конфигурируемого радио, показали точность сбора и обработки
первичных измерений в единицы метров в лабораторных условиях.