bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolución de los conocimientos sobre alimentación y nutrición en ESO y bachillerato (Evolution of knowledge about food and nutrition in ESO and high school)
Authors: Luciañez-Sanchez Gema , LeBaut-Ayuso Yannick , Valls Bautista Cristina , Solé-Llussà Anna
Published: March 2023

La sociedad presenta un aumento en la prevalencia de sobrepeso y obesidad, sobre todo en adolescentes. El abandono de la forma tradicional y saludable de alimentarse y un estilo de vida cada vez más sedentario, están detrás de este aumento, entre otras razones. Una forma de paliar estos efectos es la de formar en materia de hábitos saludables desde la infancia. Para describir el nivel de conocimientos asimilados en el ámbito de la nutrición y alimentación por el alumnado de cursos comprendidos entre primero de la ESO y segundo de Bachillerato se realizó y administró un cuestionario a 182 alumnos. Los resultados muestran que la media de respuestas correctas en primero de la ESO es de 3,72 sobre 11 mientras que, a segundo de Bachillerato, esta media se duplica hasta 7,61. De modo que, a medida que avanzan los cursos, los estudiantes profundizan en los conceptos analizados sobre nutrición y alimentación y asimismo adquieren un sentido en su contexto real.
Palabras clave: nutrición, dieta, alimentación, hábitos saludables, educación secundaria 
Abstract. Society has an increase in the prevalence of overweight and obesity, especially in adolescents. The abandonment of the traditional and healthy way of eating and an increasingly sedentary lifestyle are behind this increase, among other reasons. One way to alleviate these effects is to train in healthy habits from childhood. To describe the level of knowledge assimilated in the field of nutrition and food by the students of courses comprised between the first of the ESO and the second of the Baccalaureate, a questionnaire was designed and administered to 182 students. The results show that the average of correct answers in the first year of ESO is 3.72 out of 11, while in the second year of high school, this average doubles to 7.61. So that, as the courses progress, the students delve deeper into the concepts analyzed about nutrition and food and also acquire a meaning in their real context.
Keywords: nutrition, diet, feed, healthy habits, secondary education.
Study of Labor Market Demand at the End of the Covid-19 Fifth Wave in Győr-Moson-Sopron County of Hungary
Authors: Magyar-Stifter Viktória , Potháczky Rácz Irma
Published: March 2023

The labor market has been struggling with excess demand for several years – in part due to the „one million new jobs” program announced in 2011. Although the labor market is growing strongly, it suffers from structural problems. There are more than ten thousand job advertisements on Hungarian job portals, although in March 2022, coinciding with the curfew, a significant part of companies decided to stop their recruitment procedures or reduce the number of vacancies. And 44% of them also reduced the number of their employees. In the waning phase of the fifth wave of the pandemic, we conducted an exploratory study on the most popular job portal about what kind of job ads job seekers can find today. In our study, we present the research results and trends of job ads in Győr-Moson-Sopron County. We highlight the most important general aspects and show how the company can be made more attractive for job seekers.
Az utolsó száz méter kihívásai az e-kereskedelem logisztikában
Authors: Póka Viktor , Lányi Márton
Published: March 2023

Az e-kereskedelem növekedése már 2020. előtt is jelentős volt, azonban a pandémia és a járványra adott válaszok tovább növelték a rendelésszámokat. A boltzárások, kijárási korlátozások, a megbetegedéstől való félelem az e-kereskedelem felé irányították a vásárlókat. Ennek hatására az online kereskedelem piacán a verseny intenzívebbé vált. A kereskedők erre a csatornára összpontosítottak növelve a logisztikai kiszolgálásra rótt terheket. Vizsgálatunk középpontjába a kiszállítással kapcsolatos kérdések kerültek, hiszen a kereskedelem ezen típusában a csomagok és rendelések kézbesítése sok esetben kihívást okoz.
Resposta funcional, consumo e preferência do predador Podisus nigrispinus (Hemiptera: Pentatomidae) por larvas e pupas de Tenebrio molitor (Coleoptera: Tenebrionidae)
Authors:   , Santos Carlos Antonio Alves dos
Published: March 2023

Alternativas de controle de insetos que visam proteger o meio ambiente sem prejudicar a saúde humana são estudadas. O controle biológico, uso de inimigos naturais para supressão de pragas, é uma dessas alternativas utilizadas no manejo integrado de pragas (MIP). Podisus nigrispinus (Dallas, 1851) (Hemiptera: Pentatomidae) é um inimigo natural bastante utilizado em programas de controle biológico na agricultura e silvicultura, pois se adapta a diferentes presas e temperaturas, facilitando a criação massal. A qualidade e o número de presas afetam os parâmetros biológicos e reprodutivos. A resposta funcional é utilizada para avaliar o comportamento de um predador em diferentes densidades de presa. O objetivo deste trabalho foi avaliar a resposta funcional, consumo e preferência de P. nigrispinus por larvas e pupas de Tenebrio molitor (Linnaeus, 1758) (Coleoptera: Tenebrionidae), presa alternativa utilizada na criação desse predador. A resposta funcional (tipo de resposta funcional, taxa de ataque e tempo de manuseio) de P. nigrispinus foi avaliada em cinco densidades de presas (1, 2, 4, 8 e 16 larvas ou pupas de T. molitor) com dez repetições por 72 horas. A preferência de P. nigrispinus pela fase de desenvolvimento de T. molitor foi avaliada em teste de livre escolha em placas de Petri, com uma presa (larva e pupa) nas extremidades opostas da mesma. Cento e vinte indivíduos de P. nigrispinus (60 por sexo) foram utilizados. A escolha era registrada quando o predador P. nigrispinus inseria seu estilete na larva ou pupa de T. molitor e permanecia por, pelo menos, 10 minutos se alimentando. O consumo de presas foi avaliado com 30 machos e 30 fêmeas, desse predador, individualizados em tubos de vidro com uma presa (larva ou pupa) de T. molitor, por tubo, em três repetições. O peso (mg) de larvas e pupas de T. molitor foi registrado, a cada 24 horas, durante sete dias. A resposta funcional do predador P. nigrispinus foi do tipo II para larva e pupa de T. molitor, com diminuição no consumo em relação ao aumento do número dos dois tipos de presas. A taxa de ataque e o tempo de manuseio foram semelhantes para P. nigrispinus alimentado com larvas e pupas de T. molitor. O predador P. nigrispinus preferiu pupas (11,17 ± 0,4014) que larvas (8,833 ± 0,4014) de T. molitor. O consumo de P. nigrispinus foi significativo para larvas (27,95 ± 11,44) e pupas (30,49 ± 22,71) de T. molitor. A resposta funcional e o consumo de P. nigrispinus com larvas e pupas de T. monitor confirma, seremestas fases de vida da presa adequadas para P. nigrispinus. Apesar da preferência do predador P. nigrispinus por pupas de T. molitor, o mesmo se alimenta de forma satisfatória de larvas dessa presa. Palavras–chave: Controle biológico. Criação massal. Densidade. Inimigos naturais. Meio ambiente.
Aphid honeydew affects positively Chrysoperla externa fitness
Authors:   , Barroso André Mazochi
Published: March 2023

Dealing with arthropod pests is one of the main problems of modern agriculture. The use of agrochemicals has often become inefficient due to the acquisition of resistance by pests, in addition to being harmful to human health and to the environment. For these reasons, eco-friendly methods of combating pests are currently gaining ground. This is the case of Conservation Biological Control, which involves practices such as the use of companion plants to provide shelter and/or food resources and to attract natural enemies of pests, allowing their population establishment in the agroecosystem. The objective of this dissertation was to study the suitability of food resources directly or indirectly provided by sorghum (Sorghum bicolor) as a companion plant to the lacewing Chrysoperla externa. First, I assessed the suitability of honeydew produced by aphids (Melanaphis sp.) on S. bicolor as food resource for C. externa adults. The survival of C. externa adults was higher and females did oviposit viable eggs when they had access to Melanaphis sp. honeydew. Females without access to honeydew did not oviposit. I followed by evaluating whether pollen of sorghum is suitable to C. externa adults when offered alone or in combination with Melanaphis sp. honeydew. The lacewings survived longer and females oviposited viable eggs when they had access to honeydew but the pollen presence did not influence oviposition or adult survival. These results show that sorghum can act as a companion plant to provide honeydew for C. externa adults when infested by aphids of the genus Melanaphis, aiming for the conservation of these biocontrol agents in agroecossystems due to longer survival and oviposition of viable eggs. This strategy should only work when the aphids are not pests of the main crops. Keywords: Green lacewing. Sorghum bicolor. Melanaphis. Pollen. Conservation Biological Control.
Quarta Onda de Imigrantes Brasileiras e Brasileiros em Portugal
Authors: Poleto Oltramari Andrea , Alves Scherer Laura , Mendonça Fraga Aline , Peixoto João , Magalhães Fernandes Duval
Published: March 2023

A presente pesquisa objetivou compreender como se apresenta a quarta onda de imigrantes do Brasil para Portugal e suas relações de trabalho. O quadro teórico adotado baseou-se em: a) panorama sobre migração internacional; b) mercado de trabalho para imigrantes e flexibilização laboral; c) marcadores sociais de diferença em contextos migratórios. A pesquisa, de cunho qualitativo, realizou entrevistas semiestruturadas com 37 brasileiros e brasileiras e observação-participante em associações de acolhimento. A análise dos dados contou com a análise de conteúdo. Emergiram quatro grupos de imigrantes, tendo como base tipo de registro de entrada no país, formação e trabalho, os quais foram analisados com base em três categorias: redes, classe e gênero. Os principais resultados apontam características que aprofundam as análises sobre a quarta onda e para a relevância de abordagens interseccionais no campo das migrações.
Guidance sources at work
Authors: Mendes Athayde André Luiz , Vaz Torres Claudio , Thomason Stephanie Jeanne
Published: March 2023

This study aimed to statistically test the influence of employees’ sociodemographic characteristics on their use of sources of guidance at work in the United States and Brazil. To achieve this objective, 220 employees from a Brazilian university and 166 employees from an American university filled out a paper-and-pencil questionnaire comprised of a previously-validated scale. Correlations and multiple linear regressions were run to test this influence. Among other results, American employees with higher education levels are more likely to use Informal Rules as sources of guidance at work. In turn, Brazilian employees with previous experience in managerial positions are more likely to use their Own Experience as a source of guidance at work. The results yielded from the tests suggest to managers, human resource professionals, and psychologists which sociodemographic characteristics are relevant to predicting the use of guidance sources at work, contributing, for instance, to recruitment and selection processes.
Revisão Sistemática das Características Empregadas para Qualificar um Arranjo Produtivo Local (APL)
Authors: Sanches Vessoni Pantolfi Vinicius , Satolo Eduardo Guilherme , Hengler Corrêa Bernardo Cristiane , Bernardo Roberto
Published: March 2023

Como forma de buscar sucesso e sobrevivência em diferentes mercados, empresas buscam aglomerar-se no que se denomina de arranjo produtivo local (APL). Sendo assim, o objetivo deste trabalho foi, por meio de uma revisão sistemática da literatura, identificar as principais características empregadas para qualificação de um APL. Para tanto foram buscados artigos científicos publicados nos últimos 10 anos na Scopus database. Foram aceitos artigos nos idiomas português e inglês, nas áreas pertinentes ao estudo. Ao final das buscas, treze artigos compuseram a amostra de artigos selecionados. Realizada a leitura completa dos artigos, analisou-se seus respectivos objetivos e características de qualificação de APL. Chegou-se à conclusão de que o quociente locacional, o índice de participação relativa, o índice Hirschman-Herfindahl, o porte das empresas, o número de funcionários e o nível de cooperação são as principais características utilizadas para qualificar um APL.
Impact of Traumatic Disorder on Families of United Nation Soldiers Deployed on Peace Keeping Missions
Authors: Chi Nevile
Published: March 2023

Purpose: The study sought to investigate the use of impact of traumatic disorder on families of United Nation soldiers deployed on peace keeping missions.

Materials and Methods: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.

Findings: The findings show that wives of military personnel on peacekeeping mission are beleaguered by a number of psychosocial problems among which are loneliness, fear that the husbands might lose their lives during the mission, children missing their fathers and lack of guidance and counseling on how coping could be achieved.

Unique Contribution to Theory, Practice and Policy: The quantity of life theory was very instrumental in this study, future studies anchored on different context could benefit from the theory. The study recommended that, there is need to pay increased attention to military families affected by combat deployment to the current conflicts. Transitions such as those engendered by the deployment cycle offer prime opportunities to strengthen already present skills and introduce new strategies. Policy maker’s needs to provide a framework for understanding and supporting military families affected by deployment, and adapt, a new implementation of family care being developed specifically for military families that empowers parents to be their children’s best teachers.
The Use of Sanction by Super Powers Countries and Their Impact on Other Countries
Authors: Trump Bobby
Published: March 2023

Purpose: The study sought to investigate the use of sanction by super powers countries and their impact on other countries.

Methodology: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.

Findings: The study concluded that sanctions are one of the most important and most attractive ways for deference of the targeted country. Security Council's sanctions that are issued on the basis of Article 41 of the Charter are the proof of this claim. But bilateral and multilateral sanctions outside the UN framework have many applications.

Unique Contribution to Theory, Practice and Policy: The study recommended that, U.S. and Russia must recognize the lasting quality of international politics and create a basis of understanding as such by acknowledging the legitimate interests and concerns of the others. The study also recommended that countries could consider establishing the authority and effective procedures or mechanisms to propose persons and entities to the Security Council for designation in accordance with relevant Security Council resolutions which impose targeted financial sanctions in the context of the financing of proliferation of weapons of mass destruction.
THE USE OF MOLECULAR BIOLOGICAL DIAGNOSIS METHODS IN THE CONTROL SYSTEM OF THE EPIZOOTIC SITUATION FOR PSEUDOMONOSIS IN FUR FARMS
Authors: Tsiapsha Y. I. , Dubanevich О. V. , Andrusevich A. S. , Struk M. S. , Kuchvalski M. V.
Published: March 2023

Pseudomonosis of fur-bearing animals is widespread in the world. Morbidity can be 60%, mortality over 70%. One of the fastest and simplest types of diagnosis of this disease is the PCR method. Given the wide diversity of Pseudomonas in antigenic structure, there is a study of this diversity by molecular biological methods, such as RAPD and ERIC PCR, since the intraspecific difference between Pseudomonas strains should be taken into account in the specific prevention of Pseudomonas.
RELATIONSHIP OF HEPATITIS E PIG INFECTION WITH LIVER DAMAGE
Authors: Krasochko P. A. , Kurdeko A. P. , Zhavoronok S. V. , Krasochko P. P. , Borisovets D. S. , Prokopenkova T. M.
Published: March 2023

The article provides the results of a comparative analysis of the relationship of swine hepatitis E virus infection with vari-ous liver lesions in animals on industrial pig breeding complexes. A wide territorial spread of infection of pigs with hepatitis E virus has been established, which proceeds in the form of a latent infection without pronounced clinical signs. When comparing the results of serological studies for the presence of antibodies to the hepatitis E virus in pigs and the results of post-murder de-tection of hepatitis, the incidence of pathology is almost the same, 13.6 % and 14.8 %, respectively. In the case, toxic liver dystro-phy, as the leading cause of death, accounts for 7.7−10.2 % of cases.
STATE OF CELLULAR AND HUMORAL IMMUNE IN COWS, VACCINATED AGAINST INFEC-TIOUS PNEUMOENTERITIS
Authors: Ponaskov M. A.
Published: March 2023

This article presents the results of studying the effect of vaccines against infectious pneumoenteritis on the parameters of blood immunity of pregnant cows. It has been established that vaccines against infectious pneumoenteri-tis activate the studied indicators of cellular and humoral immunity.
ANALYSIS OF DESIGNS OF DEVICES FOR INTERNAL CLEANING OF FEED SILOS
Authors: Punko A. I. , Dyba E. V.
Published: March 2023

The article analyzes the technologies and designs of existing devices for internal cleaning of silos from various physico-biological contaminants.
AN OVERVIEW OF MOMORDICA CHARANTIA: A NEUTRACEUTICAL APPROACH FOR DEPRESSION
Authors: Singh Chandra Pratap , Maheshwari Kamal Kishore
Published: March 2023

The Cucurbitaceae family, which includes Momordicacharantia Linn. (M. Charantia), has a widely geographical distribution throughout tropicaly and subtropicaly areas in the world. Since ancient times, its fruit used for vegetable diet, herbal therapy and is utilised in drugs to cure diabetes mellitus. These phytochemicals include proteins, polysaccharides along with flavonoids , few triterpenes, saponins, ascorbic acid and a number of steroids. This plant also contains steroids , proteins , ascorbic acid , Polysaccharides, saponins, flavonoids. According to reports, M. Charantia exhibits a variety of biological activities, including those that are hepatoprotective, anticancer, antibacterial, antiviral, antitumor, immunomodulating, antioxidant, ant-diabetic, ant-helmintic, anti-ulcer,anti-inflammatory, studies conducted in vivo and vitro have shown that, M. Charantia may also have toxicity or harmful actions depending on the situation. This current review article, chemical components of MomordicaCharantia.
DESENVOLVIMENTO DE QUADRO ALTERNATIVO PARA BICICLETA POR MEIO DA ANÁLISE DE ELEMENTOS FINITOS (FEA)
Authors: Lima Paniago Argelio , Nunes Araujo Vinícius Gabriel
Published: March 2023

Este trabalho teve como objetivo desenvolver um quadro de bicicleta no qual se tivesse como principais parâmetros resistência mecânica, leveza e custo-benefício, tendo como abordagem para desenvolvimento, primordialmente, a metodologia de seleção de materiais conhecido como Método Ashby. Na sequência, fez-se a definição do design ergonômico para uso urbano, a modelagem utilizando-se das ferramentas Autodesk Inventor® e a utilização da metodologia de Análise de Elementos Finitos - MEF (Finite Element Analyses – FEA) com o “software” ANYS®. Estes caminhos foram escolhidos por tornarem a concepção do projeto moderna e com o detalhamento que não seria possível com a utilização de ferramentas tradicionais. Com o uso do método Ashby foi determinada a utilização do compósito de fibra de aramida em matriz epóxi para a construção do quadro, seguido da análise pelo método dos elementos finitos, onde obteve-se a confirmação da rigidez e baixa massa do quadro, seguindo parâmetros que melhorem a ergonomia do usuário.
POSEBNOSTI RADNOG ODNOSA DRŽAVNIH SLUŽBENIKA U BOSNI HERCEGOVINI
Authors: Topić Dario
Published: March 2023

Osnovni cilj ovog rada je utvrditi pojam, status i pravni položaj
državnih službenika u Bosni i Hercegovini. U radu će se razmatrati
ocjenjivanje i napredovanje državnih službenika u institucijama Bosne
i Hercegovine kao i definiranje odgovornosti državnih službenika za
povrede službene dužnosti.
Rad obuhvaća analizu pojma službeničkog odnosa, koji predstavlja
dvostrani odnos države kao organizacije koja raspolaže javnim
ovlaštenjima ili neke javne službe i službenika u službeničkom odnosu;
radno-pravna obilježja službeničkog odnosa te pravnu prirodu istoga.
Bosna i Hercegovina je reformirala svoje službeničko zakonodavstvo
i uspostavila institucije i procedure, ali taj proces nije u potpunosti
dovršen prije svega zbog složenosti ustavnog i institucionalnog
uređenja, zato je neophodno ukazati na osnovne razlike koje postoje na
nivou institucija države, entiteta i Brčko Distrikta.
Presudan utjecaj na razvoj i poboljšanje kvalitete službeničkog prava
u Bosni i Hercegovini imaju europski standardi službeničkog prava, u
cilju modernizacije i poboljšanja kvalitete i efikasnosti javne uprave, što
ujedno i predstavlja jedan od kriterija za članstvo u Europsku uniju.
Ključne riječi: državni službenici, službenički odnos, službeničko pravo, Europska
unija.
MEĐUNARODNOPRAVNA OBILJEŽJA ISTOČNE EUROPE S POSEBNIM OSVRTOM NA UKRAJINU
Authors: Popović Vesna , Zovko Danijela
Published: March 2023

Istočna Europa danas prolazi kroz krizu koja ima mnogo obilježja:
društvena, politička, gospodarska, ideološka, kulturna. Agresija Rusije
na Ukrajinu događaj je koji će obilježiti budućnost Europe i globalnoga
svjetskog poretka. Postojeće stanje u Istočnoj Europi, odnosno oružanom
agresijom na Ukrajinu nemilosrdno su, brutalno i namjerno zgažena i
prekršena sva međunarodnopravna, humanitarna i druga pravila koja
reguliraju ponašanje suverenih i nezavisnih država u međunarodnim
odnosima. Autori u radu ukazuju da međunarodna zajednica, odnosno
Europska unija, ima ključnu ulogu u stabilnosti i sigurnosti Istočne
Europe. Razvoj regionalnih odnosa u istočnom susjedstvu ovisi o
pristupu Europske unije ključnim akterima poput Ukrajine. Prema
tome, neophodno je prepoznavanje Ukrajine kao važnog ekonomskog
i političkog aktera u Europi, što treba voditi i dubljem angažmanu s
Europskom unijom. S druge strane, bitno je da se poštuju i postupno
provode demokratske reforme koje će Ukrajinu približiti Europskoj
uniji i osigurati joj status demokratskoga lidera u regiji.
Ključne riječi: Istočna Europa, Europska unija, međunarodni odnosi, identitet
Ukrajine, ukrajinska kriza.
Lactobacillus acidophilus Supplementation Improves the Innate Immune Response and Disease Resistance of Striped Catfish (Pangasianodon hypophthalmus Sauvage, 1878) Juveniles against Aeromonas hydrophila
Authors: Akter Mst. Nahid , Hashim Roshada , Sutriana Amalia , Mohd Nor Siti Azizah , Janaranjani M.
Published: March 2023

A bacterium Lactobacillus acidophilus (LAB) was evaluated for its probiotic potential on the health status of striped catfish (Pangasianodon hypophthalmus, Sauvage, 1878) juveniles. Triplicate groups of striped catfish (21.69 ± 0.18 g) were fed twice daily at 2.5 % of body weight, with 0 (control), 103, 105, 107 and 109 CFU/g LAB diets for 12 weeks. The fish were challenged intraperitoneally with 1×106 CFU mL−1 of Aeromonas hydrophila after 12 weeks of feeding trial and the mortalities were recorded over 21 days. The haematological, immunological parameters and histopathological changes of liver were assessed both in pre- and post-challenged fish groups. Results revealed that feeding the fish with supplemented diets significantly increased (p < 0.05) the survival after challenged with A. hydrophila. Compared to the control diet, a significant improvement in packed cell volume, red blood cell, white blood cell and lymphocyte counts were observed in LAB supplemented diets in the pre-challenged fish groups. After 3-week post challenged, the hematological parameters, immunoglobulin and survival were significantly high in fish fed with LAB supplemented diets at 105 CFU/g and above, while only the lysozyme activity was significantly high after 2-week post-infection. Histopathological result revealed that severe necrosis was found in the liver of striped catfish fed with the control diet after challenged with A. hydrophila which was not seen in the case of LAB supplemented diets. Thus, the results suggest that administration of LAB at 105 CFU/g of diet improves the innate immune response of striped catfish juveniles.
HIGHLIGHTS

Dietary Lactobacillus acidophilus (LAB) supplementation improved survival of striped catfish after challenge with Aeromonas hydrophila
LAB supplementation enhanced the non-specific immunity of juvenile’s striped catfish
LAB supplementation improved the histopathology of pre- and post-challenge liver of striped catfish juveniles

GRAPHICAL ABSTRACT
Prediction of Cytotoxicity Against HepG2 by Quantitative Structure-Activity Relation (QSAR) Modelling
Authors: Nguyen Nhung Phuong , Nguyen Oanh Kieu Thi , Tran Nghia Dinh , Pham Hai The
Published: March 2023

Hepatocellular carcinoma (HCC) is the dominant subtype of liver cancer with very low survival rate but the chemotherapy for HCC is still in grey zone due to the limited efficacy and high toxicity profile of approved drugs raising the heavy demand on drug development for HCC. The study aimed to establish a desirability based quantitative structure activity relation (QSAR) model to predict the activity of chemical compounds against one of HCC cell line (HepG2). Different support vector machine (SVM) models were constructed and ensembled to 10 virtual screening protocols. These protocols were validated by an external dataset in combination with decoys as interference. Results showed that ensemble models exhibited improved area under the Receiver Operating Characteristic Curve (ROC), sensitivity, and specificity compared to base models in training and test set. When being validated for virtual screening to recover known active molecules in the mixture with known inactive and decoy compounds, all virtual screening protocols have good performance with good Boltzmann-Enhanced Discrimination of ROC (BEDROC) and enrichment factor (EF). The best protocol with BEDROC of 0.63 and EF of 29.55 was suitable for further screening of active compounds against HepG2 cell line.
HIGHLIGHTS

Ensemble quantitative structure-activity relationship (QSAR) models improved the performance of single models
Cytotoxicity prediction was transformed to desirability score as a general output for easily integration in multi-objective optimization
Virtual models for screening of HepG2 cytotoxicity compounds were well validated

GRAPHICAL ABSTRACT
Isolation of Genes Encoding for Human Epidermal Growth Factor (hEGF) from Human Blood: In Vitro and In Silico Study
Authors: Maelani Imelda , Suhartono Suhartono , Zulkarnain Zulkarnain
Published: March 2023

The 6.12 kDa human epidermal growth factor (hEGF) protein is expressed in the body and plays a role in cell proliferation and differentiation. This research aims to isolate the hEGF genes, determine the phylogenetic relationship between organisms based on the hEGF gene, construct the 3D structure of the hEGF protein, and identify the precise binding position between the hEGF protein and the tested Myosin-9. DNA was isolated from blood of healthy individuals followed by amplification using specified primers. DNA sequencing was utilized to identify the amplification results before generating the  phylogenetic trees. The retrieved sequences were then modeled using the Swiss model and docking proteins in silico. In three samples, DNA was successfully amplified to 700 bp and the phylogenetic analysis revealed that the three hEGF gene samples belonged to the same clades. With a 30 % identity seq, aligned result sequences modeled using the Swiss model created proteins which were not homologous. The outcomes of this modeling were compared to the hEGF protein from the database, which had a sequence identity of greater than 90 %. The i-RMSD value of the target protein (5.4 +/- 0.4), the Van der Waals energy (-29.3 +/- 1.7), and the Z-score were determined by simulation (-1.7). These results indicate a potential interaction between the isolated EGF protein and the myosin-9 tested.
HIGHLIGHTS

Human Epidermal Growth Factor (hEGF) protein is a potential protein expressed in the body and plays a role in cell proliferation and differentiation
Isolation of the EGF gene through human blood can be carried out to get data on protein size, phylogenetic analysis, and protein structure
The results of in vitro study were modeled in silico to obtain the three-dimensional structure as well as intermolecular interactions of the protein
Information beginning this study is used in follow-up research to predict EGF communications with other molecules

GRAPHICAL ABSTRACT
Tectonic Implication of the Permo-Triassic Khao Yai Mafic Volcanic Rocks in Nakhon Nayok Province, Thailand: Evidence from Geochemistry and Rare Earth Elements (REEs)
Authors: Jundee Patcharin Kosuwan , Panjasawatwong Yuenyong , Limtrakun Phisit , Salyapongse Sirot
Published: March 2023

The Permo-Triassic Khao Yai Volcanics in Nakhon Nayok Province, Thailand, is a part of the Loei-Phetchabun-Nakhon Nayok Volcanic Belt. The purpose of this study is to clarify the geochemistry and REEs characteristic of Khao Yai Volcanics that is useful for identifying the paleo-environment or tectonic setting eruption in this area. The least-altered, mafic volcanic rocks from the Permo-Triassic Khao Yai volcanics, are seriate-textured to porphyritic, with variable amounts of phenocrysts/microphenocrysts. The mineral compositions include plagioclase, clinopyroxene, orthopyroxene, olivine, minor Fe-Ti oxide mineral, amphibole, apatite, biotite/phlogopite, monazite/zircon, glassy, and quartz. The geochemical characteristic of the Khao Yai Volcanics informed that the rocks had the same parental magma with different degrees of crystal fractionation. Most of the mafic volcanic rocks are subalkalic andesite on the basis of their Zr/TiO2 and Nb/Y ratios and calc-alkalic on diagrams Ti-Zr, Ti-Zr-Y, Hf-Th-Ta and Y-La-Nb. The least-altered mafic volcanic rocks have (La/Sm)cn and (Sm/Yb)cn ranging from 2.41 to 2.71 and 1.86 to 2.22, respectively.  The studied calc-alkalic andesite are analogous to the Quaternary calc-alkalic dacite and andesite from Maca Volcano, Patagonian Andes and the Middle Eocene andesite from Shimokoh cauldron, SW Japan in terms of chondrite-normalized REEs and N-MORB normalized patterns. Accordingly, the studied Khao Yai volcanics have been developed in an active continental margin, formed by eastward underthrusting Paleo-Tethys, the leading edge of Shan-Thai, beneath Indochina in the Late Permian to Early Triassic.
HIGHLIGHTS

New tectonic model of the Permo-Triassic Khao Yai mafic volcanic rocks in Nakhon Nayok Province, Thailand
The geochemistry and rare earth elements (REEs) analysis by XRF and ICP-MS
The REEs analog to modern volcanic rock
The classification of pre-Jurassic volcanic belt in Thailand

GRAPHICAL ABSTRACT
Las brechas del cáncer entre México y Estados Unidos
Authors: Martínez Gabriel
Published: March 2023

Se miden las “brechas del cáncer” entre Estados Unidos y México, con el fin de identificar sesgos conductuales, causas de las diferencias y ámbitos de mejora. Se emplean datos esta-tales para cuatro décadas, 31 tipos de cáncer (para 22 hay variables de riesgo), en seis métri-cas (mortalidad, prevalencia, incidencia, y años de vida perdidos por discapacidad, muerte y total). Estados Unidos tiene tasas de mortalidad más elevadas que México en general y por neoplasias. El análisis de regresión indica que no considerar los factores de riesgo (ade-más de la demografía) genera sesgos importantes en la medición.
Good Clinical Practices
Authors: Kokare P.S
Published: March 2023

Good Clinical Practice (GCP) is an international ethical and scientific quality standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials. It also serves to protect the rights, integrity and confidentiality of trial subjects. It is very important to understand the background of the formation of the ICH-GCP guidelines as this, in itself, explains the reasons and the need for doing so. In this paper, we address the historical background and the events that led up to the formation of these guidelines. Today, the ICH-GCP guidelines are used in clinical trials throughout the globe with the main aim of protecting and preserving human rights.
Fast Disintegration Tablets Problems and Evaluation
Authors: Akansha S Ganeshpure  , Rushikesh Shinde  , Avesh Iliyas Sumar  , Nitin B. Kohale  , Suraj B. Rathod
Published: March 2023

Over the past ten years, the demand for fast disintegrating tablets (FDTs) has grown steadily, and the field is now one of the fastest-growing segments of the pharmaceutical industry. For many medications, oral drug delivery is still the preferred method of administration. Scientists have created FDTs that are more patient-friendly and convenient as a result of recent technological advancements. These tablets dissolve or disintegrate in the mouth when placed there without the need for additional water, making it simple to administer the active pharmaceutical ingredients. The formulation’s acceptance and usefulness led to the creation of a number of FDT technologies. Solid unit dose forms known as FDTs dissolve or disintegrate quickly in the mouth without chewing or drinking. FDTs, orally disintegrating tablets, are advantageous for elderly and paediatric patients
Sustainable Development of Civil Engineering, Construction and Building Technology
Authors: Smt. Nisha Pandey
Published: March 2023

Sustainable development of civil engineering, construction and building technology can be supported by fundamental scientific achievements and development theories. The current paper aims at over viewing the state of the art in terms of published papers related to theoretical methods that are applied to support sustainable evaluation and selection processes in civil engineering. The review is limited solely to papers referred to in the Clarivate Analytic Web of Science core collection database. As the focus is on development, it aims at reviewing how the papers on developments and applications have been distributed and journals. The articles are grouped by research domains, problems analyzed and the decision-making approaches used. The findings of the current review paper show that Devekionebt if applications have been constantly growing and particularly increased in the last three years, confirming the great potential and prospects of sustainable development of civil engineering, construction and building technology.
Use of Language and Science Education
Authors: Dr. Bhavana Pandey
Published: March 2023

The growth of any country depends upon the growth of science and technology of that country. In the world of knowledge, language plays a vital role in imparting knowledge.Language use in education has been an issue in a multilingual set up dominated by a colonial language, such as English which has become an over pervading effect because of its global stature vis-à-vis regional language/vernacular. A student who had studied up to high school in regional language finds it very difficult to cope up with the science education at intermediate/plus two stage and further on, compared to an English medium student. As a result of this many students drop out of education. Science education at the school level and at the higher education are not in contiguous relationship due to which the students switching over from the secondary level to higher secondary level faces many problems and there are many drop outs every year. They have to deviate from their chosen path and one of the impediments is language issues, particularly switching from regional language medium to English language medium. The paper aims at this issue and need to be addressed properly by administrators, planners, educationists, linguists, etc.
ACOMPANHAMENTO DA ENFERMAGEM NA SAÚDE DO TRABALHADOR
Authors: Dos Santos Danilo Ferreira , Siqueira Diego Silveira
Published: March 2023

Introdução: O trabalho gera e modifica as condições de viver, adoecer e morrer dos indivíduos, considerado um dos principais determinantes sociais que impactam a saúde. De acordo com o Ministério da Saúde, atenção à saúde do trabalhador é estabelecer novas formas de compreensão da relação saúde do trabalhador entre o trabalho e o processo saúde/doença. Objetivo: Discutir a atuação do profissional de enfermagem no serviço de saúde ocupacional nos diferentes níveis de atenção. Métodos: Trata-se de uma revisão narrativa da literatura, tendo como base a busca de artigos científicos indexados as bases de dado na Biblioteca Virtual de Saúde (BVS), utilizando como descritores: saúde do trabalhador, atuação da enfermagem, saúde ocupacional, funções da enfermagem. Realizada a busca foram encontradas 100 produções científicas, aplicando filtros e critérios estabelecidos de inclusão e exclusão, após ficaram 10 artigos que compuseram o estudo. Resultados: Após buscas de artigos e análises, elucida nessa pesquisa duas categorias, sendo elas, a primeira categoria Saúde do Trabalhador e Políticas Públicas, e a segunda categoria o enfermeiro e sua contribuição na saúde do trabalhador. Conclusões: Evidenciou a atuação do Enfermeiro do Trabalho na Serviço de Saúde Ocupacional nos diferentes níveis de atenção, trazendo conhecimentos a respeito da área de Saúde do Trabalhador focando o campo da Enfermagem. Sendo assim, o Enfermeiro do Trabalho deve trazer em sua “bagagem” um rol de conhecimentos tanto na área de saúde, como na área administrativa, já que a necessidade de gestão é extremamente relevante no desempenho das suas atividades.
GERMINAÇÃO DE SEMENTES DE ESPÉCIES DE IPÊS COM APLICAÇÃO DE ÁCIDO HÚMICO E FÚLVICO
Authors: Dias Afonso de Carvalho , De Oliveira Daniel Azevedo Mendes , Caldana Cristiane Renata Gaiotto
Published: March 2023

Introdução: O Ipê é muito utilizado em projetos paisagísticos em áreas urbanas,e também em plantios de recuperação florestal. O desafio atual em viveiros é buscar formas de melhorar seu crescimento e germinação visando potencializar o desenvolvimento das mudas. Objetivo: Testar o efeito da aplicação de produtos à base de ácidos fúlvicos e ácidos húmicos em sementes de Ipê Amarelo (Handroanthus chrysotrichus) e do Ipê roxo (Handroanthus avellanedae). Metodologia: Foram testados quatro tratamentos: Ácido Húmico; Ácido Fúlvico; Ácido Húmico + Ácido Fúlvico e Testemunha (sem ácido), com delineamento em blocos casualizados. Foram aferidos os índices de velocidade de germinação (IVG), porcentagem de germinação, tempo médio de germinação (TMG), abertura das primeiras folhas, quantidade de folhas, desenvolvimento radicular e tamanho total das mudas. A estatística foi gerada no programa SISVAR 5.8. Resultados: No experimento com o ipê amarelo foi observado que a testemunha apresentou os melhores resultados em todos os parâmetros analisados, porém as bandejas utilizando ácidos húmico apresentaram melhor desenvolvimento radicular e maior tamanho total das mudas, no teste de quantidade de folhas os ácido juntos apresentaram mais folhas que a testemunha. O ipê roxo apresentou melhores respostas às substâncias aplicadas, se sobressaindo as aplicações do ácido húmico. Conclusão: Os efeitos da aplicação individual e em conjunto dos ácidos foram mais evidentes para o ipê roxo do que para o ipê amarelo. Novos testes devem ser realizados para verificar a substância e concentração adequada para auxiliar no desenvolvimento de cada espécie.
EFFECT OF MONETARY POLICY ON SELECTED MACROECONOMIC VARIABLES IN NIGERIAN
Authors: Mary Nkechinyere Onwudiegwu  , Nonso John Okoye  , Hillary Chijindu Ezeaku  , Nnamdi Lawrence Okeke
Published: March 2023

This study analyzed the effects of monetary policy on selected macroeconomic variables in Nigeria from 1986 to 2019. The relationship between monetary policy and macroeconomic variables in Nigeria has been a contentious issue due to inconsistent implementation and empirical findings. The study specifically evaluated the impact of monetary policy rate, cash reserve ratio, liquidity ratio, and money supply, as independent variables, on inflation and employment rate, the dependent variables. The study design was ex-post facto and utilized the Error Correction Mechanism (ECM) Model for estimation. The analysis revealed a negative and insignificant relationship between the monetary policy instruments and the selected macroeconomic variables. The conclusion was that the Central Bank of Nigeria's monetary policy adjustments have not effectively improved macroeconomic conditions in Nigeria. The study recommended increasing awareness of financial inclusion in rural areas, promoting collaboration between monetary and fiscal policy managers, and directing efforts towards enhancing the development of both the money and capital markets.

Keywords: Monetary Policy, Macroeconomic Variables, Nigeria.
Prognostic Impact of Modified Glasgow Prognostic Score in Patients with Heart Failure with Mildly Reduced Ejection Fraction
Authors: Bezgin Tahir , Çelik Aziz İnan , Karagöz Ali , Baytuğan Nart Zafer , Çağdaş Metin , Karakoyun Süleyman , Kaymaz Cihangir
Published: March 2023

Introduction: Inflammation and malnutrition may trigger heart failure development and progression (HF). However, the relationship of the modified Glasgow prognostic score (mGPS), which is derived from C-reactive protein and albumin with mildly reduced ejection fraction HF (HFmrEF), is not well-known. We aimed to determine whether the modified Glasgow prognostic score (mGPS) is helpful for the prediction of all-cause mortality in patients with HFmrEF.

Patients and Methods: Patients with HFmrEF admitted to our outpatient clinic between January 2016 and January 2020 were enrolled. All-cause mortality was defined as the primary endpoint. The mGPS was calculated and, its association with overall survival was determined.

Results: Data were analyzed for 259 patients. The mGPS≤ 1 in 172 (66%), and 2 in 87 (34%) patients, respectively. Higher mGPS was related to worse results of routine biomarkers associated with prognosis, especially NT-proBNP [777 (112-4564) pg/mL vs. 350 (65-3521) pg/mL, respectively, p< 0.0001)]. In multivariable Cox model, NT-proBNP [1.83 (1.32-2.55), p< 0.0001], mGPS 2 vs. ≤1 [2.43 (1.2-4.93), p= 0.013], and coronary artery disease (CAD) [3.15 (1.46-6.82), p= 0.003] were found to be independently associated with all-cause mortality.

Conclusion: The immune-nutritional score mGPS predicts mortality during long-term follow-up of patients with HFmrEF. The mGPS might be used for risk status assessment of HFmrEF.
Sacubitril/Valsartan Treatment in Heart Failure Increases The Left Ventricular Ejection Fraction: A Bayesian Analysis
Authors: Birdal Oğuzhan , Saygı Mehmet , Demir Gündoğmuş Pınar , Aksakal Emrah , Özkalaycı Flora
Published: March 2023

Introduction: Heart failure is an important leading cause of mortality and morbidity despite optimal medical treatment and device therapy. Sacubitril/valsartan, a first-generation drug, was approved to use heart failure treatment recently. There are limited studies on the relationship between sacubitril/valsartan and left ventricular contraction. In our study, we aimed to evaluate the changes in left ventricular ejection fraction (LVEF) after sacubitril/valsartan treatment.

Patients and Methods: Fifty-two patients with heart failure and reduced ejection fraction (HFrEF) were enrolled in this study. The baseline demographic, clinical, and echocardiographic characteristics of 52 patients were compared using the Bayesian method.

Results: Fifty-two patients with heart failure and reduced ejection fraction (HFrEF) were included in the final analysis (66.2 ± 9.3 years, 69.2% male). Sacubitril/valsartan initial dose was low in 44.2% of patients, and intermediate in 55.8%. In the low initial dose population, the increase in absolute LVEF was 3.87 (95% HDI 1.53-6.20) and in the intermediate initial dose population, the increase in absolute LVEF was 5.89 (95% HDI 4.18-7.61). In the female population, the increase in absolute LVEF was 5.56 (95% HDI 3.49-7.63) and in the male population 4.75 (95% HDI 2.91-6.58) respectively.

Conclusion: In this study, we demonstrated that sacubitril/valsartan is associated with increased LVEF regardless of baseline clinical characteristics.
Adaptation to Turkish of the Self-Care of Heart Failure Index: A Validity and Reliability Study
Authors: Afşar Füsun , Kayalı Serpil , Kesgin Vildan , Akgün Taylan , Yılmaz Habip
Published: March 2023

Introduction: Heart failure is a chronic and progressive disease with increasing prevalence and incidence worldwide, despite advances in science and technology, and it necessitates long-term follow-up, treatment, and care. Self-care in heart failure is one of the fundamental elements of quality of life and disability-free living. The aim of this study was to assess the validity and reliability of the Turkish version of the Self-Care of Heart Failure Index v.2 (SCHFI).

Patients and Methods: The study sample included 233 patients who presented with a diagnosis of heart failure and volunteered to participate in the research at a training and research hospital. The data were collected using a personal information form and the SCHFI. The SCHFI was translated into Turkish, and the internal consistency coefficient and the item-total points reliability coefficient were analyzed for the reliability study. To determine structure validity, Explanatory Factor Analysis and Confirmatory Factor Analysis were performed.

Results: The adaptation of the SCHFI to Turkish culture was found to have high structure validity and internal consistency in the reliability and validity studies.

Conclusion: We concluded that the Self-Care of Heart Failure Index can be used as a unidimensional scale.