bluuebunny/crossref_metadata_2025 huggingface dataset:
Findings of a videofluoroscopic swallowing study in patients with dysphagia
Authors: Cui Qingjia , Wei Bing , He Yuan , Zhang Qian , Jia Weiwei , Wang Haiying , Xi Jianing , Dai Xin
Published: August 2023

Objective

Swallowing examination is crucial in patients with dysphagia. We aimed to compare qualitative and quantitative videofluoroscopic swallowing study (VFSS) results to provide reference for standardizing quantitative parameters.

Materials and methods

In total, 117 patients with dysphagia were included, 38 with Parkinson’s disease and 39 and 40 in convalescence following cerebral hemorrhage and infarction. VFSS was both qualitatively and quantitatively analyzed.

Results

A significant difference of Oral transit time was found between the oral motor function grades (p < 0.001), also was swallowing reaction times found between swallowing reaction duration grades (p < 0.001), and soft palate lift duration between the soft palate lift grades (p < 0.001). Superior hyoid bone movement (p < 0.001), anterior hyoid bone movement (p < 0.001), hyoid pause time (p < 0.001), and hyoid movement duration (p = 0.032) had significant differences between the hyoid laryngeal complex movement grades, as did the pharyngeal cavity transit time among the cricopharyngeal muscle opening duration grades (p < 0.001). The laryngeal vestibule closure duration differed among the glottic closure grades (p < 0.001). No statistically significant difference in upper esophageal sphincter opening diameter (p = 0.682) or duration (p = 0.682) among the cyclopharyngeal muscle opening duration grades. The pharyngeal area at rest did not significantly differ among the different vallecular residue (p = 0.202) and pyriform sinus residue (p = 0.116) grades.

Conclusion

Several quantitative parameters can reflect the swallowing assessment process well. Further optimization of quantitative parameters is recommended.
Impact of ongoing intravenous thrombolysis until completion of endovascular treatment in large vessel occlusion stroke patients
Authors: Wischmann Johannes , Pradhan Cauchy , Zimmermann Hanna , Keidel Linus , Tiedt Steffen , Dimitriadis Konstantinos , Liebig Thomas , Höglinger Günter , Kellert Lars
Published: August 2023

Background

Recent studies have implied that ongoing intravenous thrombolysis (IVT) during endovascular treatment (ET) improves functional outcomes in patients who have undergone stroke caused by a large vessel occlusion (LVO). In this study, we investigated the effect of ongoing IVT until completion of ET on procedure duration, first-pass thrombectomy rate, and periprocedural complications.

Methods

We analyzed patients from the German Stroke Registry-Endovascular Treatment dataset, collected between June 2015 and December 2021. Primary outcomes were modified Rankin Scale (mRS) score after 3 months and achievement of a Thrombolysis In Cerebral Infarction (TICI) score of 2b-3. Secondary parameters included ET duration, first-pass thrombectomy, and periprocedural complications.

Results

Of the 13,082 patients in the dataset, 1,639 met the study inclusion criteria. A total of n = 317 patients (19.3%) underwent ongoing IVT until completion of ET, while IVT was completed prior to ET in 1,322 patients (80.7%). Ongoing IVT was associated with higher rates of achievement of an mRS score of 0–2 (or a back-to-baseline) after 3 months [odds ratio (OR) 1.53; 95% confidence interval (CI) 1.08–2.17]. Furthermore, ongoing IVT was predictive of achievement of a TICI score of 2b-3 (OR 1.37; 95% CI 1.03–1.83) and of first-pass thrombectomy (OR 2.07; 95% CI 1.51–2.84), while reducing the rate of peri-interventional complications (OR 0.64; 95% CI 0.44–0.94) and reducing ET duration by 24 min [β = −24.35; 95% CI −32.92–(−15.79)].

Conclusion

Our findings suggest that ongoing IVT until ET completion has a favorable impact on both clinical and angiographic outcomes, as well as on periprocedural conditions, regardless of the overall time intervals involved. Therefore, rapid ET after IVT should be sought in order to take advantage of the additive effect of ongoing IVT during ET. Future studies should consider IVT timing in the context of ET as a potential confounder and treatment target.
Assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms
Authors: Jegatheeswaran Lavandan , Gokani Shyam Ajay , Luke Louis , Klyvyte Gabija , Espehana Andreas , Garden Elizabeth Mairenn , Tarantino Alessia , Al Omari Basil , Philpott Carl Martin
Published: August 2023

Purpose of review

To provide a detailed overview of the assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms.

Recent findings

COVID-19-related olfactory dysfunction can have a detrimental impact to the quality of life of patients. Prior to the COVID-19 pandemic, olfactory and taste disorders were a common but under-rated, under-researched and under-treated sensory loss. The pandemic has exacerbated the current unmet need for accessing good healthcare for patients living with olfactory disorders and other symptoms secondary to COVID-19. This review thus explores the associations that COVID-19 has with psychological, neuropsychiatric, and cognitive symptoms, and provide a framework and rationale for the assessment of patients presenting with COVID-19 olfactory dysfunction.

Acute COVID-19 infection and long COVID is not solely a disease of the respiratory and vascular systems. These two conditions have strong associations with psychological, neuropsychiatric, and cognitive symptoms. A systematic approach with history taking and examination particularly with nasal endoscopy can determine the impact that this has on the patient. Specific olfactory disorder questionnaires can demonstrate the impact on quality of life, while psychophysical testing can objectively assess and monitor olfaction over time. The role of cross-sectional imaging is not yet described for COVID-19-related olfactory dysfunction. Management options are limited to conservative adjunctive measures, with some medical therapies described.
Association between added sugars and kidney stones in U.S. adults: data from National Health and Nutrition Examination Survey 2007–2018
Authors: Yin Shan , Yang Zhenzhen , Zhu Pingyu , Du Zhongbo , Yu Xiaodong , Tang Tielong , Borné Yan
Published: August 2023

Purpose

Added sugar is associated with a variety of adverse health outcomes, but its association with kidney stones is unclear. This study was to determine whether added sugar is associated with kidney stones.

Materials and methods

This nationally representative study used National Health and Nutrition Examination Survey (NHANES) datasets from 2007 to 2018 for analysis. People aged ≥20 years who reported a history of kidney stones and provided dietary recall data on added sugars were included. Weighted proportions, multivariable logistic regression analysis and stratified logistic regression were used to evaluate the associations between added sugars and kidney stones by adjusting potential confounders.

Results

Totally 28,303 adults were included, with weighted mean age [95% confidence interval (CI)] of 48.03 (47.56, 48.51) years, 47.74% (47.09, 48.40%) males and 52.26% (51.60, 52.91%) females. The overall mean (95% CI) energy intake from added sugars was 272.10 (266.59, 277.60) kilocalories. In the fully-adjusted multivariable model, the percentage of energy intake from added sugars was positively correlated with kidney stones. Compared to the first quartile of added sugar energy intake percentage, the population in the fourth quartile had a higher prevalence of kidney stones (OR = 1.39; 95% CI 1.17 to 1.65). Compared with the less than 5% calories from added sugar population, the more than or equal to 25% calories from added sugar had a higher kidney stone prevalence (OR = 1.88; 95% CI 1.52 to 2.32).

Conclusion

A higher percentage of energy intake from added sugars is significantly associated with a higher prevalence of kidney stones. This study provides cross-sectional evidence for the relationship between added sugars and health outcomes.
A nomogram for predicting the risk of male breast cancer for overall survival
Authors: Wen Yahui , Bai Junjie , Zheng Caihong , Liu Jiameng , Lin Shunguo , Han Hui , Xu Chunsen
Published: August 2023

Background

Male breast cancer (MBC) is a rare disease, accounting for <1% of all male carcinomas. Lack of prospective data, the current therapy for MBC is based on retrospective analysis or information that is extrapolated from studies of female patients. We constructed a nomogram model for predicting the overall survival (OS) of MBC patients and verify its feasibility using data from China.

Methods

Constructed a predictive model using 1224 MBC patients from the Surveillance, Epidemiology and End Results (SEER) registry between 2010 and 2015. The performance of the model was externally validated between 2002 to 2021 using 44 MBC patients from the Fujian Medical University Union Hospital. The independent prognostic factors were selected by univariate and multivariate Cox regression analyses. The nomogram was constructed to predict individual survival outcomes for MBC patients. The discriminative power, calibration, and clinical effectiveness of the nomogram were evaluated by the receiver operating characteristic (ROC) curve, and the decision curve analysis (DCA).

Results

A total of 1224 male breast cancer patients were in the training cohort and 44 in the validation cohort. T status (p<0.001), age at diagnosis (p<0.001), histologic grade (p=0.008), M status (p<0.001), ER status (p=0.001), Her2 status (p=0.019), chemotherapy (p=0.015) were independently associated with OS. The diagnostic performance of this model was evaluated and validated using ROC curves on the training and validation datasets. In the training cohort, the nomogram-predicted AUC value was 0.786 for 3-year OS and 0.767 for 5-year OS. In the validation cohort, the nomogram-predicted AUC value was 0.893 for 3-year OS and 0.895 for 5-year OS. Decision curve analysis demonstrated that the nomogram was more benefit than the AJCC stage.

Conclusions

We developed a nomogram that predicts 3-year and 5-year survival in MBC patients. Validation using bootstrap sampling revealed optimal discrimination and calibration, suggesting that the nomogram may have clinical utility. The results remain reproducible in the validation cohort which included Chinese data. The model was superior to the AJCC stage system as shown in the decision curve analysis (DCA).
Taxonomic and functional profiling of fecal metagenomes for the early detection of colorectal cancer
Authors: Wu Xudong , Tang Zhimin , Zhao Rongsong , Wang Yusi , Wang Xianshu , Liu Side , Zou Hongzhi
Published: August 2023

Objectives

This study aimed to identify colorectal cancer (CRC)-associated phylogenetic and functional bacterial features by a large-scale metagenomic sequencing and develop a binomial classifier to accurately distinguish between CRC patients and healthy individuals.

Methods

We conducted shotgun metagenomic analyses of fecal samples from a ZhongShanMed discovery cohort of 121 CRC and 52 controls and SouthernMed validation cohort of 67 CRC and 44 controls. Taxonomic profiling and quantification were performed by direct sequence alignment against genome taxonomy database (GTDB). High-quality reads were also aligned to IGC datasets to obtain functional profiles defined by Kyoto Encyclopedia of Genes and Genomes (KEGG). A least absolute shrinkage and selection operator (LASSO) classifier was constructed to quantify risk scores of probability of disease and to discriminate CRC from normal for discovery, validation, Fudan, GloriousMed, and HongKong cohorts.

Results

A diverse spectrum of bacterial and fungi species were found to be either enriched (368) or reduced (113) in CRC patients (q<0.05). Similarly, metabolic functions associated with biosynthesis and metabolism of amino acids and fatty acids were significantly altered (q<0.05). The LASSO regression analysis of significant changes in the abundance of microbial species in CRC achieved areas under the receiver operating characteristic curve (AUROCs) of 0.94 and 0.91 in the ZhongShanMed and SouthernMed cohorts, respectively. A further analysis of Fudan, GloriousMed, and HK cohorts using the same classification model also demonstrated AUROC of 0.80, 0.78, and 0.91, respectively. Moreover, major CRC-associated bacterial biomarkers identified in this study were found to be coherently enriched or depleted across 10 metagenomic sequencing studies of gut microbiota.

Conclusion

A coherent signature of CRC-associated bacterial biomarkers modeled on LASSO binomial classifier maybe used accurately for early detection of CRC.
Case Report: Primary hepatic neuroendocrine tumor: two cases report with literature review
Authors: Tang Yongsheng , Chen Xianyu , Lu Xu , Yuan Zenan , Yang Yang , Qiu Chunhui , Li Hua
Published: August 2023

Background & Aims

Primary hepatic neuroendocrine tumors (PHNETs) are rare malignant liver tumors that present diagnostic challenges owing to their rarity and absence of specific clinical features. This study aimed to investigate the characteristics of this rare liver tumor to enhance our understanding of the disease, improve diagnostic accuracy, and explore standardized diagnostic and treatment approaches.

Case description

During physical examination, two elderly women, aged 64 and 74 years, were found to have liver masses. 18F-FDG Positron Emission Tomography-Computed Tomography (18F-FDG PET-CT) and Ga68-DOTATATE PET-CT scans of both individuals revealed multiple liver masses that were initially suspected to be hepatic neuroendocrine tumors. Subsequent puncture pathology confirmed the diagnosis of neuroendocrine tumors. Furthermore, in Case 1, the tumor was also detected by 18F-FDG PET-CT in the lung, suggesting a metastatic tumor, in conjunction with liver immunohistochemistry and imaging findings. Laboratory tests revealed no significant abnormalities in liver function or autoimmune liver disease indicators, and there was no evidence of viral hepatitis infection. However, partial hepatectomy was not indicated for cases with distant metastasis or multiple space-occupying lesions. Individualized treatment approaches have been developed for such situations. A large portion of the tumor underwent Transarterial Embolization (TAE), and targeted combination chemotherapy or endocrine therapy was administered based on the pathological results. During regular follow-ups a 13 and 12 months, the tumor remained stable. The patients’ quality of life was good, and their psychological well-being was healthy. They led active lifestyles, demonstrated a thorough understanding of their disease and its progression, and actively cooperated during the follow-up process.

Conclusion

Our findings suggest that a combination of serological, radiological, and immunohistochemical examinations can aid in the diagnosis of PHNET. In addition, we determined that TAE combined with drug therapy could be an effective method for controlling PHNET progression. Regular postoperative follow-ups are important for monitoring the prognosis and tumor progression status of patients with PHNET.
Marine heatwave temperatures enhance larval performance but are meditated by paternal thermal history and inter-individual differences in the purple sea urchin, Strongylocentrotus purpuratus
Authors: Leach Terence S. , Hofmann Gretchen E.
Published: August 2023

Marine heatwave (MHW) events, characterized by periods of anomalous temperatures, are an increasingly prevalent threat to coastal marine ecosystems. Given the seasonal phenology of MHWs, the full extent of their biological consequences may depend on how these thermal stress events align with an organism’s reproductive cycle. In organisms with more complex life cycles (e.g., many marine invertebrate species) the alignment of adult and larval environments may be an important factor determining offspring success, setting the stage for MHW events to influence reproduction and development in situ. Here, the influence of MHW-like temperatures on the early development of the California purple sea urchin, Strongylocentrotus purpuratus, were explored within the context of paternal thermal history. Based on temperature data collected during MHW events seen in Southern California from 2014–2020, adult urchins were acclimated to either MHW or non-MHW temperatures for 28 days before their sperm was used to produce embryos that were subsequently raised under varying thermal conditions. Once offspring reached an early larval stage, the impact of paternal and offspring environments were assessed on two aspects of offspring performance: larval size and thermal tolerance. Exposure to elevated temperatures during early development resulted in larger, more thermally tolerant larvae, with further influences of paternal identity and thermal history, respectively. The alignment of paternal and offspring exposure to MHW temperatures had additional positive benefits on larval thermal tolerance, but this tolerance significantly decreased when their thermal experience mismatched. As the highest recorded temperatures within past MHW events have occurred during the gametogenesis of many kelp forest benthic marine invertebrate species, such as the purple sea urchin, such parental mediated impacts may represent important drivers of future recruitment and population composition for these species.
Predicting corn tiller development in restrictive environments can be achieved to enhance defensive management decision tools for producers
Authors: Veenstra Rachel L. , Hefley Trevor J. , Berning Dan , Messina Carlos D. , Haag Lucas A. , Prasad P.V. Vara , Ciampitti Ignacio A.
Published: August 2023

Introduction

While globally appreciated for reliable, intensification-friendly phenotypes, modern corn (Zea mays L.) genotypes retain crop plasticity potential. For example, weather and heterogeneous field conditions can overcome phenotype uniformity and facilitate tiller expression. Such plasticity may be of interest in restrictive or otherwise variable environments around the world, where corn production is steadily expanding. No substantial effort has been made in available literature to predict tiller development in field scenarios, which could provide insight on corn plasticity capabilities and drivers. Therefore, the objectives of this investigation are as follows: 1) identify environment, management, or combinations of these factors key to accurately predict tiller density dynamics in corn; and 2) test outof-season prediction accuracy for identified factors.

Methods

Replicated field trials were conducted in 17 diverse site-years in Kansas (United States) during the 2019, 2020, and 2021 seasons. Two modern corn genotypes were evaluated with target plant densities of 25000, 42000, and 60000 plants ha -1. Environmental, phenological, and morphological data were recorded and evaluated with generalized additive models.

Results

Plant density interactions with cumulative growing degree days, photothermal quotient, mean minimum and maximum daily temperatures, cumulative vapor pressure deficit, soil nitrate, and soil phosphorus were identified as important predictive factors of tiller density. Many of these factors had stark non-limiting thresholds. Factors impacting growth rates and photosynthesis (specifically vapor pressure deficit and maximum temperatures) were most sensitive to changes in plant density. Out-of-season prediction errors were seasonally variable, highlighting model limitations due to training datasets.

Discussion

This study demonstrates that tillering is a predictable plasticity mechanism in corn, and therefore could be incorporated into decision tools for restrictive growing regions. While useful for diagnostics, these models are limited in forecast utility and should be coupled with appropriate decision theory and risk assessments for producers in climatically and socioeconomically vulnerable environments.
Secretome analysis revealed that cell wall remodeling and starch catabolism underlie the early stages of somatic embryogenesis in Pinus nigra
Authors: Pernis Miroslav , Salaj Terézia , Bellová Jana , Danchenko Maksym , Baráth Peter , Klubicová Katarína
Published: August 2023

Somatic embryogenesis is an efficient mean for rapid micropropagation and preservation of the germplasm of valuable coniferous trees. Little is known about how the composition of secretome tracks down the level of embryogenic capacity. Unlike embryogenic tissue on solid medium, suspension cell cultures enable the study of extracellular proteins secreted into a liquid cultivation medium, avoiding contamination from destructured cells. Here, we present proteomic data of the secretome of Pinus nigra cell lines with contrasting embryogenic capacity, accounting for variability between genotypes. Our results showed that cell wall-related and carbohydrate-acting proteins were the most differentially accumulated. Peroxidases, extensin, α-amylase, plant basic secretory family protein (BSP), and basic secretory protease (S) were more abundant in the medium from the lines with high embryogenic capacity. In contrast, the medium from the low embryogenic capacity cell lines contained a higher amount of polygalacturonases, hothead protein, and expansin, which are generally associated with cell wall loosening or softening. These results corroborated the microscopic findings in cell lines with low embryogenic capacity—long suspensor cells without proper assembly. Furthermore, proteomic data were subsequently validated by peroxidase and α-amylase activity assays, and hence, we conclude that both tested enzyme activities can be considered potential markers of high embryogenic capacity.
Why should I switch on my camera? Developing the cognitive skills of compassionate communications for online group/teamwork management
Authors: Jayasundara J. M. P. V. K. , Gilbert Theo , Kersten Saskia , Meng Li
Published: August 2023

Introduction

Associated with learning and social isolation from each other during the pandemic-driven transition to online platforms in Higher Education (HE), many students were, and remain, reluctant to turn on their video cameras to be present with each other during their online meetings.

Using the Compassionate Mind Foundation's definition of compassion, not as an emotion, but as a psychobiological motivation to take wise action to help when self or others struggle, this comparative study examined (a) the deployment by students during online, task-focused group/team meetings, of taught verbal and non-verbal communication strategies that were explicitly compassionate and (b) the effects of these strategies on each other's social and learning experiences in these meetings, compared to when they did not use them.

Methods

Twenty-four STEM students from a sample of five Sri Lankan universities, were mixed, then divided into six groups of four students per group. This mixed-methods study, video-recorded and analyzed each group's task-focused group meetings before, then after, an online interactive 90-min training session (the intervention) in the Cognitive Skills of Compassionate Communications (CSCC) for groups/teams.

Results

Using R, SPSS and Microsoft Excel to analyse the quantitative data, a statistically significant improvement in students' screen-gaze attentiveness was identified after the CSCC intervention. The qualitative data analysis explained this and other behavioral changes that were shown to enhance students' social and learning experiences in their online meetings.

Given the strong historical and political drivers of current divisions across Sri Lankan student communities, these findings call for more urgent research on compassion as a cognitive competence for accelerating group/team cohesion and criticality across HE, and beyond.
Daily survey participation and positive changes in mental health symptom scores among Royal Canadian Mounted Police Cadets
Authors: Shields Robyn E. , Teckchandani Taylor A. , Asmundson Gordon J. G. , Nisbet Jolan , Krakauer Rachel L. , Andrews Katie L. , Maguire Kirby Q. , Jamshidi Laleh , Afifi Tracie O. , Lix Lisa M. , Brunet Alain , Sauer-Zavala Shannon , Krätzig Gregory P. , Neary J. Patrick , Sareen Jitender , Carleton R. Nicholas
Published: August 2023

Introduction

Royal Canadian Mounted Police (RCMP) officers self-report high levels of mental health disorder symptoms, such as alcohol use disorder, generalized anxiety disorder, major depressive disorder, panic disorder, and posttraumatic stress disorder. Participation in regular mental health monitoring has been associated with improved mental health disorder symptom reporting and may provide an accessible tool to support RCMP mental health. The current study assessed relationships between self-reported mental health disorder symptoms and the completion of daily surveys (i.e., daily mental health disorder symptom monitoring) by RCMP cadets during the Cadet Training Program (CTP).

Methods

Participants were RCMP cadets (n = 394; 76.1% men) in the Standard Training Program who completed the 26-week CTP and daily self-monitoring surveys, as well as full mental health assessments at pre-training (i.e., starting the CTP) and pre-deployment (i.e., ~2 weeks prior to deployment to the field). Symptoms of alcohol use disorder, generalized anxiety disorder, major depressive disorder, panic disorder, and posttraumatic stress disorder were assessed. Changes in mental health disorder symptom reporting from pre-training to pre-deployment were calculated. Spearman’s rank correlations were estimated for number of daily surveys completed and change in mental health disorder symptom scores between pre-training and pre-deployment.

Results

There were statistically significant inverse relationships between number of daily surveys completed and number of mental health disorder symptoms reported; specifically, cadets who completed more daily surveys during CTP reported fewer symptoms of alcohol use disorder, generalized anxiety disorder, major depressive disorder, panic disorder, and posttraumatic stress disorder.

Conclusion

An inverse correlation between number of daily surveys completed and mental health disorder symptom scores indicated that participation in daily mental health monitoring was associated with improvements in self-reported mental health disorder symptoms between pre-training and pre-deployment. Regular self-monitoring of mental health disorder symptoms may help to mitigate mental health challenges among RCMP cadets and officers.
Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
Authors: Clavo Bernardino , Cánovas-Molina Angeles , Díaz-Garrido Juan A. , Cañas Silvia , Ramallo-Fariña Yolanda , Laffite Horus , Federico Mario , Rodríguez-Abreu Delvys , Galván Saray , García-Lourve Carla , González-Beltrán Damián , Caramés Miguel A. , Hernández-Fleta Jose L. , Serrano-Aguilar Pedro , Rodríguez-Esparragón Francisco
Published: August 2023

Background

Patients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study was to preliminarily evaluate, in patients treated because of refractory symptoms of cancer treatment and advanced nononcologic diseases, if ozone therapy has an additional impact on self-reported anxiety and depression.

Methods

Before and after ozone treatment, we assessed (i) anxiety and depression according to the Hospital Anxiety and Depression Scale (HADS); (ii) the HRQOL (according to the EQ-5D-5L questionnaire), which includes a dimension on anxiety and depression and a visual analog scale (VAS) measuring self-perceived general health.

Results

Before ozone therapy, 56% of patients were on anxiolytic and/or antidepressant treatment. Before and after ozone therapy, the anxiety and depression HADS subscales (i) significantly correlated with the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) inversely correlated with the health status as measured by the VAS. After ozone therapy, we found a significant improvement in anxiety and depression measured by both the (i) HADS subscales and (ii) EQ-5D-5L questionnaire.

Conclusion

The addition of ozone therapy for patients with refractory symptoms of cancer treatment and advanced chronic nononcologic diseases can decrease anxiety and depression severity levels. Additional, more focused studies are ongoing to provide the needed explanatory information for this finding.
Body-oriented interventions to promote preschoolers’ social–emotional competence: a quasi-experimental study
Authors: Dias Rodrigues Andreia , Marmeleira José , Pomar Clarinda , Lamy Elsa , Guerreiro Daniela , Veiga Guida
Published: August 2023

Introduction

Social–emotional competence is foundational to children’s health and well-being. Body-oriented interventions, such as relaxation or play based interventions, have been shown to promote social–emotional competence, however more studies are needed to better understand the specific benefits of each type of body-oriented approach.

Objective

The present study aimed to examine the chronic and the acute effects of three body-oriented intervention programs (loose parts play, relaxation and combining loose parts play and relaxation) on preschoolers’ social–emotional competence.

Methods

A quasi-experimental study was carried out, including 62 preschoolers (4.44 ± 0.93 years) that were allocated into 4 groups: Loose Parts Play program (n = 17); Relaxation program (n = 17); Combined program (n = 13); and Waitlist Control Group (no intervention; n = 15). All three intervention programs had a 12-week duration, with biweekly sessions of 30-min, implemented in the preschool outdoors. To examine the chronic effects of the intervention programs, all instruments (parents’ and preschool teacher’s questionnaires, tasks and saliva) were collected at baseline and after the 12-week period. To examine the acute effects, saliva samples were collected immediately before and after the 1st and the 24th sessions, with a total of 4 collections per child.

Results

Both loose parts play and relaxation interventions significantly improved (p < 0.05) children’s positive emotion expression. Several within-groups changes were found for the Loose parts play, Relaxation and Combined programs.

Conclusion

Body-oriented interventions effectively promote preschoolers’ social–emotional competence.
Is melancholia a distinct syndrome? Recurrence, chronicity, and severity give evidence in the 50 year follow-up of the Lundby Study
Authors: Nöbbelin Linnéa , Bogren Mats , Mattisson Cecilia , Westling Sofie , Brådvik Louise
Published: August 2023

Introduction

Whether melancholia is a distinct syndrome has long been debated. One aspect of a valid syndrome is whether it allows for determination of a prognosis. The aim of this study is to investigate the course of melancholic depression versus non-melancholic depression with a focus on: (i) time to and probability of recovery from the first depressive episode, (ii) time to and risk of the first recurrence, (iii) rate of recurrence, (iv) time with depression or antidepressant medication, and (v) suicide risk.

Methods

The Lundby Study is a longitudinal community study on mental health that followed a geographically defined population (N = 3,563) for up to 50 years, 1947–1997. Subjects with first onset depression were assessed as melancholic (N = 46) or non-melancholic (N = 381) using the DSM-IV melancholic specifier. These diagnoses were made in retrospect using all available information from semi-structured interviews by psychiatrists, key informants, registers, and patient records.

Results

We found no significant difference between melancholic- and non-melancholic depression in time to and probability of recovery from the first depressive episode. The time to first recurrence was shorter in melancholic than in non-melancholic depression and the risk of first recurrence for the melancholic group was 2.77 (95% confidence interval [CI] 1.83–4.20) times the risk in the non-melancholic group. The median rate of recurrence was higher in the melancholic group, at 0.19 recurrences per year at risk (interquartile range [IQR] 0.08–0.47), compared to the non-melancholic group, at 0.10 recurrences per year at risk (IQR 0.05–0.21) (p < 0.03). The median percentage of time being depressed or on antidepressant medication was higher in the melancholic group, 17% (IQR 3–20%), compared to the non-melancholic group, 8% (IQR 7–33%) (p < 0.001). The risk of suicide was higher in the melancholic group, hazard ratio 4.13 (95% CI 1.49–11.48, p < 0.01).

Discussion

To conclude, melancholic depression had a more recurrent, chronic, and severe course with a higher suicide risk than did non-melancholic depression in the Lundby population. Although our use of retrospective diagnosis might limit interpretation of results, the findings indicate that melancholia may be useful in determining prognosis and may be a valid psychopathological syndrome.
How Plants Make Cats Happy
Authors: Bol Sebastiaan , Fuentes Jennifer , Garza Rolando , Bunnik Evelien M.
Published: August 2023

Catnip—this plant seems to make a lot of cats very happy. But did you know that not all cats like catnip? We wondered if there were other plants that have the same effect on cats that catnip has. Is it possible that some cats who do not like catnip might enjoy those other plants? We let many cats sniff catnip and several other plants to see which plants cats like. It turns out there is hope for cats who do not like catnip but still want to have a good time. But how do these plants make cats so happy? We knew that a chemical compound in catnip called nepetalactone is responsible for the effect catnip has on cats, but we found many more compounds that can do the same! Do cats respond the same way to all these plants and compounds? Read the article to find out.
Academic boredom(s): a person-centered investigation
Authors: Tempelaar Dirk , Niculescu Alexandra
Published: August 2023

Should we refer to boredom or boredoms? Research on the emotion of boredom sets itself apart from studies on other emotions by posing the question: is boredom a singular concept or does it have multiple facets? In this manuscript presenting empirical research on academic boredom, our aim is to demonstrate the justification for claiming a distinct position. Person-centered models examining university students' achievement emotions reveal the existence of multiple types of boredom, in contrast to other learning emotions that are typically represented as singular constructs. Using data generated by dispositional learning analytics applications, we further investigate the progression of learning boredom over time, exploring the impact of the pandemic and analyzing how various student learning aptitudes, such as mindsets, epistemological beliefs, epistemic emotions, learning motivation, engagement, as well as demographic factors like gender and culture, can be considered as potential antecedents or triggers of boredom. Consistent with the control-value theory of achievement emotions, we conclude that control and value constructs serve as proximal antecedents of boredom, alongside epistemic boredom as a distal antecedent. However, the relationships between boredom and its antecedents exhibit notable variations across different types of boredom.
Case report: Atlantoaxial instability and subluxation in a dog with Ehlers–Danlos syndrome
Authors: Choi Simon , Sullivan Louise , Long Sam
Published: August 2023

Ehlers–Danlos syndrome is a rare, heritable connective tissue disorder characterized by soft, hyperextensible skin, joint hypermobility, and tissue fragility, the severity of which can range from mild to severe. A 9-month-old male entire miniature Dachshund was presented following peracute tetraparesis. Neurological examination was suggestive of intracranial vestibular disease or high cervical myelopathy. MRI revealed atlantoaxial instability and subluxation, resulting in marked spinal cord compression at C1–C2, which was surgically stabilized. On discharge from the hospital, skin fragility was noted as the result of skin tearing during tape removal. A piece of full-thickness antebrachial skin was submitted for histopathology which showed changes consistent with Ehlers–Danlos syndrome. This case report describes the first case of atlantoaxial instability and subluxation in a dog as the result of a confirmed underlying collagenopathy.
Evaluating the Efficacy of the Fermentation Formula of Bacillus velezensis Strain Tcb43 in Controlling Cucumber Powdery Mildew
Authors: Kuo Chien-Chih , Huang Yi-Chiao , Deng Wen-Ling
Published: August 2023

Powdery mildew is a prevalent disease that affects cucumber crops, leading to yield reductions and declines in quality. Bacillus sp. strain Tcb43 culture medium was shown to be capable of inhibiting fungal spore germination in previous reports. In this study, the identification of the Tcb43 strain was updated to Bacillus velezensis by using whole-genome sequencing. The strain exhibited tolerance to a wide range of temperatures (12–40 °C), salinities (7–10%), and pH levels (ranging from 5 to 11). Additionally, Tcb43 demonstrated insensitivity to most tested fungicides. A new fermentation formula, Tcb43FBSO, was developed by adding 0.25% soybean oil to the fermented formula (Tcb43FB). This new formula exhibited a shelf life of up to 12 months with the decrease in bacterial count from 5.35 × 108 to 1.97 × 108 cfu/mL. Greenhouse assays showed that the treatment of potted cucumber plants with a 100-fold dilution (100×) of Tcb43FBSO for four weeks resulted in a significant reduction (64.64%) of cucumber powdery mildew compared to the mock group. In large-scale greenhouse trials, the treatment of cucumber plants with 200× of Tcb43FBSO for 5 weeks effectively suppressed powdery mildew disease, with a control rate that reached 76.6% compared to the mock group. These findings highlight the potential of Tcb43 as a biocontrol agent for managing cucumber powdery mildew and suggest its promising application in agriculture.
Division of Cow Production Groups Based on SOLOv2 and Improved CNN-LSTM
Authors: Cui Guanying , Qiao Lulu , Li Yuhua , Chen Zhilong , Liang Zhenyu , Xin Chengrui , Xiao Maohua , Zou Xiuguo
Published: August 2023

Udder conformation traits interact with cow milk yield, and it is essential to study the udder characteristics at different levels of production to predict milk yield for managing cows on farms. This study aims to develop an effective method based on instance segmentation and an improved neural network to divide cow production groups according to udders of high- and low-yielding cows. Firstly, the SOLOv2 (Segmenting Objects by LOcations) method was utilized to finely segment the cow udders. Secondly, feature extraction and data processing were conducted to define several cow udder features. Finally, the improved CNN-LSTM (Convolution Neural Network-Long Short-Term Memory) neural network was adopted to classify high- and low-yielding udders. The research compared the improved CNN-LSTM model and the other five classifiers, and the results show that CNN-LSTM achieved an overall accuracy of 96.44%. The proposed method indicates that the SOLOv2 and CNN-LSTM methods combined with analysis of udder traits have the potential for assigning cows to different production groups.
Data-Driven Projections Demonstrate Non-Farming Use of Cropland in Non-Major Grain-Producing Areas: A Case Study of Shaanxi Province, China
Authors: Linghu Linna , Sun Peijun , Zhang Meng , Wu Yue
Published: August 2023

The non-farming use of cropland has led to food insecurity in China due to drastic land use (LU) changes under the stresses of ecological restoration and urbanization, particularly in non-major grain-producing areas. Questions were raised about spatiotemporal cropland losses/gains and their drivers in these areas in the future for sustainable development of the agriculture sector. However, the answers to these questions have not been well acknowledged. This study, therefore, presents analyses of cropland area change from 1990 to 2018 and from 2018 to 2051 in Shaanxi province based on the Future Land Use Simulation (FLUS) model that follows the integration of the Shared Socioeconomic Pathway 2 and the Representative Concentration Pathway 4.5 (SSP245) within the International Coupled Model Intercomparison Project 6 (CMIP6). The results highlight that ecological restoration and fast-paced urbanization mainly drove the alarming non-farming use of cropland. The per capita cropland area is projected to increase, but the cropland loss will still occur, which potentially causes food insecurity. Thus, food security will be a challenging issue in the near future. The quantitative findings call for careful designs of LU policies, taking into account cropland protection, socio-economic development, and ecological restoration.
Cucumber Picking Recognition in Near-Color Background Based on Improved YOLOv5
Authors: Su Liyang , Sun Haixia , Zhang Shujuan , Lu Xinyuan , Wang Runrun , Wang Linjie , Wang Ning
Published: August 2023

Rapid and precise detection of cucumbers is a key element in enhancing the capability of intelligent harvesting robots. Problems such as near-color background interference, branch and leaf occlusion of fruits, and target scale diversity in greenhouse environments posed higher requirements for cucumber target detection algorithms. Therefore, a lightweight YOLOv5s-Super model was proposed based on the YOLOv5s model. First, in this study, the bidirectional feature pyramid network (BiFPN) and C3CA module were added to the YOLOv5s-Super model with the goal of capturing cucumber shoulder features of long-distance dependence and dynamically fusing multi-scale features in the near-color background. Second, the Ghost module was added to the YOLOv5s-Super model to speed up the inference time and floating-point computation speed of the model. Finally, this study visualized different feature fusion methods for the BiFPN module; independently designed a C3SimAM module for comparison between parametric and non-parametric attention mechanisms. The results showed that the YOLOv5s-Super model achieves mAP of 87.5%, which was 4.2% higher than the YOLOv7-tiny and 1.9% higher than the YOLOv8s model. The improved model could more accurately and robustly complete the detection of multi-scale features in complex near-color backgrounds while the model met the requirement of being lightweight. These results could provide technical support for the implementation of intelligent cucumber picking.
Effects of Bit Chewing on Gastric Emptying, Small Intestinal Transit, and Orocecal Transit Times in Clinically Normal Horses
Authors: Patton Molly E. , Andrews Frank M. , Bogers Sophie H. , Wong David , McKenzie Harold C. , Werre Stephen R. , Byron Christopher R.
Published: August 2023

Ileus is a common life-threatening problem in horses, and currently available treatments may be ineffective. The purpose of this study was to determine whether bit chewing, a form of sham feeding, decreases the gastric emptying time (GET), small intestinal transit time (SITT), and total orocecal transit time (OCTT) in clinically normal horses in a prospective crossover study. Nine healthy horses were acclimated and fed a standardized diet. Following 24 h of fasting, self-contained video endoscopy capsules and acetaminophen were administered into the stomach via a nasogastric tube. Each horse underwent experimental (bit chewing for 20 min every 6 h) or control (no bit chewing) conditions, with a 3-week minimum washout period between conditions. The horses were enrolled in either part of the study until all video capsules were retrieved and/or 30 days lapsed. The video capsules were recovered from manure, and GET, SITT, and OCTT were determined from a video analysis. Bit chewing significantly decreased OCTT (p = 0.015) compared to the control conditions. Bit chewing decreased GET and SITT, but the differences were not significant. The mean (median) times determined via the video capsule analysis for the bit-chewing conditions were as follows: GET, 2.34 h (2.86 h); SITT, 3.22 h (3.65 h); and OCTT, 5.13 h (6.15 h), and for the control conditions, they were as follows: GET, 3.93 h (5 h); SITT, 3.79 h (4.4 h); and OCTT, 8.02 h (9.92 h). Bit chewing decreased OCTT in healthy horses. Because this segment of the gastrointestinal tract is frequently affected by ileus, bit chewing may be a safe and inexpensive intervention for that condition in horses. Further investigation in clinical patients with ileus is warranted.
Dietary Zinc Supplemented in Organic Form Affects the Expression of Inflammatory Molecules in Swine Intestine
Authors: Medida Ramya Lekha , Sharma Ashok Kumar , Guo Yue , Johnston Lee J. , Urriola Pedro E. , Gomez Andres , Saqui-Salces Milena
Published: August 2023

Animals receiving Zinc (Zn) dietary supplementation with organic sources respond better to stress than inorganic Zn sources supplementation. The study aimed to identify the effect of different Zn sources on intestinal epithelial gene expression. In total, 45 pigs (9 per treatment) (77.5 ± 2.5 kg weight) were fed for 32 days, a corn-soybean meal diet without supplemented Zn (ZnR) or supplemented with 50 and 100 ppm of inorganic ZnCl2 (Zn50 and Zn100), and amino acid-bound organic Zn sources (LQ50 and LQ100). Gene expression changes form RNA-seq in ileum tissues of ZnR revealed changes associated with Zn insufficiency. Comparing organic with inorganic Zn sources by one-way ANOVA, pro-inflammatory cytokine interleukin 18 (IL18) was downregulated (p = 0.03) and Toll-like receptor 2 (TLR2) upregulated (p = 0.02). To determine the role of epithelial cells in response to dietary Zn, swine intestinal organoids (enteroids) were exposed to Zn restriction, ZnCl2 or LQ-Zn. In enteroids, ZIP4 expression decreased with added Zn compared with Zn-restriction (p = 0.006) but Zn sources did not affect (p > 0.05) IL18 or TLR2 expression. These results suggest that organic Zn may stimulate TLR2 signaling possibly affecting immune response, while decreasing the proinflammatory cytokine IL18 expression in non-epithelial cells of intestinal mucosa.
Use of Danish National Somatic Cell Count Data to Assess the Need for Dry-Off Treatment in Holstein Dairy Cattle
Authors: Henningsen Maj Beldring , Denwood Matt , Kirkeby Carsten Thure , Nielsen Søren Saxmose
Published: August 2023

In Denmark, PCR testing of dairy cattle is commonly used to select animals for the antibacterial treatment of intramammary infection (IMI) during the dry-off period. IMI is associated with a high somatic cell count (SCC), routinely recorded for milk quality control for most commercial dairy herds. This study aimed to compare SCC curves over the lactation among dairy cows with positive vs. negative PCR test results for four major IMI pathogens. Data from 133,877 PCR-tested Holstein cows from 1364 Danish conventional dairy herds were used to fit a nonlinear mixed-effects model using a modified four-parameter Wilmink function. We stratified the data into first, second, third or fourth and later parity and fitted Wilmink curves to all SCC observations between 6 and 305 days in milk. The PCR tests were taken before dry-off at the end of the lactation to investigate which animals qualified for selective dry cow therapy. A PCR Ct-value of 37 and below was used to determine if an animal was PCR positive for any of the following IMI pathogens: Staphylococcus aureus, Streptococcus agalactiae, Str. dysgalactiae and Str. uberis. Our findings showed that mean SCC curve fits were higher for PCR-positive animals in all four parity groups and across lactations. The use of SCC data fitted to the entire lactation for multiple lactations enabled quantification of overall differences in SCC curves between cattle with and without detected IMI, adjusted for parity group and stage of lactation. These findings are relevant to the use of SCC to support treatment decisions.