bluuebunny/crossref_metadata_2025 huggingface dataset:
The effectiveness of family empowerment model on early detection ability of risk pregnancy during the COVID-19 pandemic
Authors: Mardiyanti Ika , Nursalam  , Ernawati Ernawati , Devy Shrimarti Rukmini , Anggasari Yasi
Published: December 2022

Introduction: Many pregnant women and their families are lack to carry out the examination to detect earlier about high-risk pregnancies. Family empowerment models can improve the ability of families to early detection of pregnancy during the COVID-19 pandemic. This study aims to analyze the effectiveness of the family empowerment model on the ability to detect early pregnancy at risk during the COVID-19 pandemic.
Methods: This study used an explanatory survey with a cross-sectional study approach and interventions of the family empowerment model on early detection ability of risk pregnancy. Sampling using the Probability sampling method with simple random sampling, a sample size of 100. Independent variables are interventions of the family empowerment model, while dependent variables of early detection ability of risk pregnancy during the covid-19 pandemic. Data collection instrument using questionnaires. The research data were analyzed using Structural Equation Modeling (SEM) based on variance or SEM-based components, known as Partial Least Squares (PLS).
Results: The influence of personal factors, resource factors, cognitive behavioral factors, interpersonal factors, filial values, and commitments showed t-statistics > 1.96 and p-values <0.05. This means that there is a significant effect on all of these variables on family empowerment. The resulting coefficient is positive 0.080 so it can be said that better family empowerment tends to increase the ability of families in early detect high-risk pregnancies. That means there is a family empowerment model that makes participants feel more responsive, and alert, pay attention to self-care, and immediately check with health workers if there are danger signs.
Conclusion: After being given the family empowerment model intervention almost all respondents were good in the ability to detect early pregnancy at risk during the COVID-19 pandemic contributed to increasing family involvement in intensive care for pregnant women to prevent pregnancy complications.
Successful rate of glaucoma surgery in uveitis glaucoma
Authors: Elsa Gustianty  , Novaqua Yandi  , R. Maula Rifada  , Andika Prahasta
Published: December 2022

Introduction: Glaucoma is one of the most common complications in uveitis. The surgical intervention has been known for a lower success rate in Uveitis Glaucoma (UG). However, it is still a treatment of choice when medical therapy no longer could control the intraocular pressure (IOP). This study aims to describe UG's demographic and clinical characteristics that received glaucoma surgery and the outcome.

Methods: Medical records of UG patients that received glaucoma surgery in 2018-2019 were reviewed. Age, gender, type and etiology of uveitis, duration of uveitis, intraocular pressure (IOP), visual acuity, gonioscopy, ocular characteristic, previous surgery and laser, current surgery, and complication were studied. Success was defined as IOP ≤21 mmHg or reduction >20% from baseline and >6mmHg with or without medication. Failure is defined in the presence of surgery complication that leads to a change of IOP, uncontrolled IOP that needs additional surgery, and visual acuity becomes no light perception (NLP).

Results: 48 patients (57 eyes) with UG underwent glaucoma surgery. The mean age was 47,23±14,62. Anterior uveitis was the most common type of UG, with a mean uveitis duration before surgery was 13,75±17,65 months. The mean initial IOP was 35,81±13,30 mmHg, at the final visit 15,09±3,36. The mean follow-up duration was 6,41±4,02 months. The overall partial success was 75,44% in one month, 67,74% in 6 months

Conclusion: A decrease in IOP was found in all surgery interventions, including Glaucoma Drainage Device (GDD) implant, trabeculectomy with 5-Fluorouracil (5FU), and combined trabeculectomy cataract surgery with or without 5FU, and cyclodestructive laser surgery. There was a high percentage of successful surgery but many losses to follow-up eyes in a short follow-up period.
Risk Factors of Titanium Mesh Exposure: Experience from a Tertiary Referral Center
Authors: Kurniawan Christian Beta , Akhmad Imron  , Muhammad Rainda Farhan
Published: December 2022

Introduction: Titanium mesh is commonly used to reconstruct the cranium in cranioplasty procedure. Although it is generally well-tolerated, erosion of the overlying soft tissue due to the implant exposure remained as a major risk that could impair patients' outcome. This study aimed to investigate the potential risk factors of titanium mesh exposure.
Methods: Medical records from patients who underwent titanium mesh cranioplasty within the period of July 2016 to July 2020 were retrieved. Patients' demographic and characteristics were reviewed to investigate the potential risk factors in titanium mesh exposure.
Results: Twenty-three patients were included in this study with the mean age of 44.6 (+10.9) years. Fourteen patients (60.9%) acquired titanium mesh exposure in less than 6 months after cranioplasty surgery. In majority, the duration of surgery were more than 3 hours (65.2%). Intraoperative blood loss volume was less than 500 cc in 8 patients (34.8%), 500-1000 cc in 8 patients (34.8%), and more than 1000 cc in 7 patients (30.4%). Nineteen patients had bone defect of >10 cm and the indications for craniectomy were tumor resection in 56.5% patients, followed by infection in 17.4%. The sign of infection was present in 12 patients (52.2%). Only 2 patients (8.7%) had radiotherapy after cranioplasty. One patient was diagnosed with polycythemia vera.
Conclusion: Titanium mesh exposure following cranioplasty surgery is a complication that might affect the patients' overall outcome. Female predominance, long surgery duration, excessive intraoperative blood loss might be correlated with higher risk of titanium mesh exposure.
Post-Chemotherapy Monocytopenia as a Predictor of Chemotherapy – Induced Neutropenia in Breast Cancer Patients
Authors: Ardhiansyah Azril Okta , Manuaba IB. Tjakra Wibawa , Widiana I Ketut
Published: December 2022

Background: Chemotherapy-induced neutropenia (CIN) is chemotherapy's most frequent myelosuppression effect. Previous studies have examined static prognostic factors to assess dynamic neutrophil changes in each cycle. This study focuses on post-chemotherapy monocytopenia as a more dynamic predictor of CIN. This research aimed to know whether post-chemotherapy monocytopenia can be used as a predictor of CIN in breast cancer patients undergoing the chemotherapy cycle.
Methods: This research used a prospective and a retrospective longitudinal cohort of breast cancer patients undergo a CAF regimen at Sanglah Hospital Denpasar. The research was conducted on 30 samples for three cycles (90 total cycles). Monocyte data is taken in the first week (days 4 to 9), and neutrophil data is taken in the second week (days 10 to 16).
Results: From statistical analysis with interval data scale, we obtained that p 0.001 with Pearson correlation 0.613 for cycle 1, p 0.001 with Pearson correlation 0.611 for cycle 2, and p 0.003 with Pearson correlation 0.522 for cycle 3.
Conclusions: In conclusion, post-chemotherapy monocytopenia can be used to predict the occurrence of chemotherapy-induced neutropenia (CIN) with the strongest positive correlation in the first cycle.
Pregnancy outcomes in pregnant women with diabetes treated with insulin alone and insulin with metformin
Authors: Elsaeed Usama Ahmed , Reda Ismail Riad  , Ahmed Taher  , Mahmoud Elnokeety  , Sherif  Elanwary
Published: December 2022

Aim: The goal of this study was to compare maternal and neonatal results in diabetic pregnant ladies who were treated either insulin and metformin or insulin only.Methods: 220 pregnant diabetic women with type 1, 2 or gestational diabetes were randomisely assigned into two groups .each group is 110 pregnant diabetic women. One group takes insulin and metformin treatment to achieve glycemic targets and other take insulin only treatment. Pregnancy results in 110 ladies who stayed solely on insulin have been compared to pregnancy results in 110 pregnant diabetic ladies treated with insulin and metformin who were matching for age, weight, as well as ethnicity.Results: No significant variations in maternal risk factors existed at the start of the study. Group II from enrolling to term, they gained significantly more weight (5.90 vs. 4.39   kg;   P < 0.000). When it came to gestational hypertension, there was no significant difference between groups I and II (14.5 against 19.1%, P = 0.367), pre-eclampsia (7.27 vs. 9.09%, P = 0.622),insulin dosage was decreased in group I statistically significant (mean 39.5±16.5 vs. 55.4±17.5 units, P= 0.000), vaginal delivery (41.8 vs. 47.3%, P = 0.416) or rate of elective Caesarean section (39.1 vs. 32.7%, P = 0.325), rate of emergency caesarean section (19.1 vs. 20%, P=0.865), perinatal loss  (4 cases in group II vs. 3 cases in group I;P=0.701). Group I had a lower rate of neonatal morbidity; prematurity (16.63 vs. 24.55%, P = 0.417), neonatal hypoglycemia (7.3 vs. 24.5 %, P= 0.000), respiratory distress (13.64 vs. 30 %, P= 0.003), neonatal jaundice (13.6 vs. 33.6%, P < 0.000) and admittance to the newborn intensive care unit (24.55 vs. 35.45%, P = 0.077). Macrosomia occurrence (There was a significant difference in birth weight centiles > 90 [group I (16.4%) vs. group II (29.1%); P = 0.024]. The incidence of polyhydramnios was significantly different [group I (13.6%) vs. group II (32.7%); P = 0.001].Shoulder dystocia [group ? (2.7%) vs. group II (4.5%); P=0.721].Conclusions: Diabetic pregnant women who were treated with insulin plus metformin who had equal baseline risk factors for unfavourable pregnancy outcomes gained less weight and needed less insulin to maintain glycemic control. Furthermore improved neonatal outcomes as macrosomia, neonatal hypoglycemia, respiratory distress and special care baby admission compared with those treated with insulin alone.
Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study
Authors: Waluyo Yose , Agussalim Bukhari  , Endy Adnan  , Artika Sari Rajwani , Ahmad Yasin  , Insani Nanda Wahyuni  , Budu
Published: December 2022

Background: Knee osteoarthritis (KOA) is a degenerative joint disease with relatively high prevalence globally and is one of the leading causes of disability in the elderly population. Dextrose prolotherapy (DPT) has been proven effective in improving functional outcomes in knee osteoarthritis. The effect of hypertonic dextrose on cartilage biomarkers has not been evaluated.
Purpose: To evaluate the association between a cartilage biomarker and changes in clinical outcomes among patients with KOA who received dextrose prolotherapy (DPT).
Patients and methods: This study was conducted with a cross-sectional design. Twenty-six participants received DPT at weeks 1, 5, and 9. Our primary measures were urinary c-terminal telopeptides of type II collagen (uCTX-II), measured by an enzyme-linked immunosorbent assay (ELISA), and the WOMAC score, measured at baseline and week 12.
Results: There were significant improvements in all WOMAC subscales and uCTX-II levels after DPT. There is no significant correlation between biomarker levels with the WOMAC score as a functional outcome indicator in KOA after DPT (p > 0.05), but there are positive correlations between pain, functional, total WOMAC score, and uCTX-II.
Conclusion: DPT may reduce cartilage degradation and improve functional outcomes in osteoarthritic knees. Significant drops in uCTX-II levels can affect functional outcomes, especially pain, functional and total WOMAC scores.
Clinical and laboratory comparison between End-Stage Kidney Disease patients with and without COVID-19: a cross-sectional study in a top referred hospital of West Nusa Tenggara
Authors: Asmara I Gede Yasa , Agustriadi I Gusti Ngurah Ommy , Sujaya I Made , Thalib Salim Said , Lestari Rina , Fatrullah Suryani Padua , Widiasari Komang Sri Rahayu , Ajmala Indana Eva , Octora Metta
Published: December 2022

Background: The initial presentation of hospitalized End-Stage Kidney Disease (ESKD) patients with and without coronavirus disease 2019 (COVID-19) is similar and can overlap. We aimed to compare clinical dan laboratory characteristics of the COVID-19 positive and negative patients to help clinicians screen and differentiate hospitalized ESKD patients.
Methods: We reviewed data from the medical record of ESKD patients hospitalized between May 1, 2020, and April 30, 2021. The study comprised all suspected COVID-19 patients. The COVID-19 positive was based on results from RT-PCR for SARS-CoV-2. The bivariate analysis was used to compare the positive and negative groups. The association of all characteristics and diagnosis of COVID-19 were then evaluated by multivariable analysis.
Results: There was twenty-nine percent of confirmed COVID-19 in 176 ESKD patients. The proportion of dyspnea, pulmonary edema, pleural effusion, and cardiomegaly were lower in the COVID-19 positive group. Diastolic blood pressure, pulse rate, white blood cell differential counts, and potassium were lower in the COVID-19 positive group. Using a multivariate analysis, eosinophil count <0.04 x103µl (P<0.001, OR 3.50, 95%CI:0.123-0.665), monocyte count <0.69 x103µl (P=0.004, OR 2.54, 95%CI:0.166-0.931), and neutrophil-to-lymphocyte ratio (NLR) <3.13 (P=0.044, OR 3.18, 95%CI:0.102-0.968) were associated with the presence of COVID-19.
Conclusions: Leukocyte differential count and chest x-ray should be evaluated as an initial screening of COVID-19 in hospitalized ESKD. Low levels of monocyte and eosinophil count and mild elevation of NLR were associated with COVID-19 in ESKD patients.
Patency rate difference of the arteriovenous fistula with and without pre-anastomosis balloon dilatation in chronic kidney disease patients
Authors: Suhartono Raden , Mochtar Chaidir Arif , Alwi Idrus , Lydia Aida , Kekalih Aria , Soetikno Vivian , Nugroho Teguh Dwi
Published: December 2022

Background: Arteriovenous fistula (AVF) failure rate in chronic kidney disease patients is relatively high due to inadequate feeding arteries and draining veins. The primary balloon angioplasty (PBA) dilatation technique is a way to mitigate AVF failure. There have not been many studies to determine the patency rate with and without PBA. This study analyzed the patency rate and the number of patency failures in Indonesia AVF patients with and without PBA.
Methods: A retrospective cohort study was conducted in AVF surgery patients from 2019 to 2021 with or without PBA with a total sample technique. The patient was choosen without AVF surgery in the same arm with had follow-up every three months for three years. We excluded incomplete medical record data and unfollowed patients six weeks after surgery. The Kaplan–Meier method used the log-rank test to estimate each group's patency rate. The p-value<0.05 was considered significant.
Results: There were 60 subjects, of which 29 were with PBA and 31 were without PBA. There was a significant difference between the two groups regarding venous diameter and postoperative venous flow volume (p<0.01). The log-rank test showed a significant difference in patency failure in the group without PBA (35.5%, mean patency rate 56.3 weeks) compared to the group with PBA (10.3%, mean patency rate 104.4 weeks) with p=0.028. The median duration showed that 50% of the group without PBA experienced patency failure at week 59.3. In contrast, until the observation's end, the PBA group experienced patency failure of less than 50%.
Conclusion: Using the PBA technique can reduce the incidence of patency failure and maintain longer patency in patients with AVF.
Effectivity of uv-light exposure on bacterial and fungal growth in Channa striata collagen-chitosan composite dressing for wound healing
Authors: Andini Ary , Prayekti Endah , Kamaliyah Nur Indah , Halimah Nur
Published: December 2022

Introduction: Channa striata collagen-chitosan wound dressing (3:1 v/v) was founded contaminate by bacterial and fungal. Therefore, to suppress bacterial and fungal contamination in Channa striata collagen-chitosan composite dressing, it needs several efforts such as sterilization under Ultra-Violet Light Exposure. The study aimed to determine UV-light exposure duration to supress bacterial and fungal growth on C. striata collagen-chitosan composite dressing.
Methods: C. striata collagen was extracted from skin and scales using 2% HCl for 48 hours, then neutralized using NaOH 1 M until collagen fibers appeared. Chitosan powder dissolved in 2% acetic acid. Afterward C. striata collagen and chitosan liquid (1:3 v/v) were mixed and formed until wound dressing was reached. Wound dressing was sterilized under UV exposure for 0, 5, 10, 15, and 30 minutes. Chitosan dressing was used as a negative control.
Results: The results of the study showed that the total number of bacteria and fungi decreased significantly with increasing time of exposure of UV light on composites dressing with a value of p=0.001 for bacterial growth and a value of p= 0.005 for fungus growth. The UV exposure on collagen-chitosan dressing to reduce bacterial and fungal growth proved effective in 10 minutes.
Conclusions: The UV light exposure treatment can reduce bacterial and fungal contamination on collagen-chitosan composites on each addition duration exposure descriptively.
The role of post-operative glutamine serum level and one-year survival rate of stage III of colorectal cancer patients: a single center study
Authors: Muamar Muhamad , Budhi Ida Bagus , Soewoto Widyanti , Agustriani Nunik , Ismail Darmawan
Published: December 2022

Introduction: Colorectal cancer (CRC) occurs, accounting for 11.5% of all patients with cancer in Indonesia. The less the spread of cancer, the higher the life expectancy of patients with cancer. Glutamine is involved in tumor cell proliferation and growth. This study aims to verify the correlation of serum glutamine levels with the one-year survival rate of patients with stadium III colorectal cancer at Dr. Moewardi Hospital, Surakarta, Indonesia.
Method: A quantitative analytic-observational longitudinal study (Cohort) was conducted from May 1st, 2020, to September 30th, 2021. Inclusion criteria were the CRC patients with stage III and could be followed up for one year. Exclusion criteria were the CRC patients who had other systemic problems. The patient’s blood glutamine levels were taken three months postoperatively measured by Glutamine Assay kit (Colorimetric) ab197011 and evaluated clinically for one year. Glutamine levels in the blood are low if they are less than 52 ng/µL. The parameters assessed were glutamine serum level and survival rate of colorectal cancer patients. Statistical analysis using the Chi-square test and the Kaplan Meier method was employed to obtain the survival curve. Analysis to compare survival rate with glutamine levels used the Cox regression model.
Results: A one-year survival rate in patients with stadium III colorectal cancer was 95.5% at post-operative glutamine levels of ≥ 52 ng/µL and 65.4% at post-operative glutamine levels of < 52 ng/µL. The mean progressive free survival rate was 11.818 months (95%CI=11.470-12.166) at post-operative glutamine levels of ≥ 52 ng/µL and 10.038 months (95%CI=8.913-11.164) at post-operative glutamine levels of < 52 ng/µL. The overall free survival rate was 11.955 months (95%CI=11.868-12.042) at post-operative glutamine levels of ≥ 52 ng/µL and 10.885 months (95% CI=10.128-11.641) at post-operative glutamine levels of < 52 ng/µL. Patients with glutamine levels of <52 ng/µL were 8.959 times more probable to die than patients with post-operative glutamine levels of ≥ 52 ng/µL.
Conclusion: This study shows a significant relationship between serum glutamine levels and the one-year survival rate of patients with stadium III colorectal cancer at Dr. Moewardi Hospital, Surakarta, Indonesia.
Circumcision in Bali? a survey of knowledge and attitude of Balinese parents toward their son’s circumcision in elementary school Denpasar, Bali
Authors: Junior I Wayan Jorden , Darmawan Rizky , Aryawangsa Dhanu , Palguna Adi Satrya , Prahasari Nindya , Gde Oka Anak Agung
Published: December 2022

Background: Many factors were involved performing circumcision such as knowledge, religion, or culture. Circumcision was the most common surgical procedure, but considered low in Bali. This study aims to determine the general knowledge and attitudes of parents towards the decision to make circumcision in children in the city of Denpasar.
Methods: A study in Denpasar area involving 1655 questionnaires was filled out by one parent who had at least one son in the Denpasar elementary school.
Results: The response rate was 86.5% (1655); Most respondents were fathers (55.3%), Hinduism (66,8%), and educational level was high school (45%). 70,5% respondents didn’t circumcise their sons. 51% respondents believe that circumcision was necessary. Most reason to circumcision was better hygiene (52.3%). The best age for circumcision was Elementary School (76.4%). Most reason for not being circumcision was didn’t know medical benefits (30.6%). It was found that most respondents had good knowledge (71.9%). Parents with a high level of education were more positive in responding to circumcision in their sons (P <0.05). Mothers were more positive in responding to circumcision (P <0.05). no significant differences were found in the respondents of father and mother to level of knowledge about circumcision.
Conclusion: This study concluded that most respondents had well knowledge about circumcision but majority didn’t circumcise their son. More future research is needed to describe the condition of circumcision in some regions in Indonesia and it’s important to both children and parents know about advantage and disadvantage of circumcision.
The performance of various laboratory parameters to differentiate follicular thyroid carcinoma and follicular thyroid adenoma
Authors: Kelana Satriya , Susilo Dwi Hari , Sahudi
Published: December 2022

Background: Thyroid cancer continues to be a problem all over the world, with the number of cases increasing year after year. We aimed to examine the association between various laboratory parameters and follicular-type thyroid nodules. We also examined the performance of several parameters to differentiate malignant and benign follicular thyroid lesions.
Methods: This is a retrospective cohort study to determine the association between various laboratory parameters and follicular-type thyroid nodules in Dr. Soetomo General Hospital, Surabaya.
Results: A total of 62 patients were examined. The NLR in the follicular carcinoma group was 2.26 ± 1.35, whereas the NLR in the adenoma group was 2.72 ± 0.74. The average lymphocyte in the follicular carcinoma group was significantly higher than the adenoma group, 2.20 ± 0.78 vs. 1.76 ± 0.82. With a cut-off value of 2.405, NLR had a 69.40% accuracy rate for diagnosing a follicular adenoma (sensitivity: 70%; specificity: 69.2%, PPV: 30.4%, NPV: 92.3%). Lymphocyte had an accuracy of 80.6% in detecting follicular carcinoma (cut-off: 1.625; sensitivity: 80.8%; specificity: 80.0%, PPV: 95.5%, NPV: 44.4%). With an accuracy of 72.6% (cut-off: 270.500; sensitivity: 71.2%; specificity: 80.0%, PPV: 94.9%, NPV: 34.8%), platelet value is a promising parameter for differentiating follicular cancer and adenoma. There was a significant relationship between NLR, lymphocyte, and platelet with follicular-type thyroid nodules (P < 0.05 for all).
Conclusion: NLR, lymphocytes, and platelets are potential biomarkers that can be used to differentiate follicular thyroid carcinoma and follicular thyroid adenoma.
The effect of discharge planning on the stability of blood sugar levels in type 2 diabetes mellitus patients
Authors: Bistara Difran Nobel , Wardani Erika Martining , Susanti  , Santoso Andreas Putro Ragil , Fasya Abdul Hakim Zakkiy , Andini Ary
Published: December 2022

Introduction: Diabetes mellitus (DM) is a serious threat to human health in the 21st century, Indonesia as a developing country has a high number of sufferers. This study aims to analyze the effect of discharge planning on the stability of blood sugar levels in type 2 patients.
Methods: The design of this study was a Quasi-Experimental Pre and Post-test with a Control Group. The population in this study were all patients with type 2 DM, a large sample of 54 respondents, taken by purposive sampling technique. The instruments used are a glucometer, questionnaire, and discharge planning form. Data analysis used Wilcoxon statistical test for pre-treatment and control groups and the Mann-Whitney test for post-treatment and post-control.
Results: The results of the Wilcoxon statistical test pre-post-treatment obtained = 0.000 and pre-post-control obtained = 0.093. The results of post-treatment and control group obtained = 0.009 and value = 0.05. It means that there is an effect of discharge planning on the stability of blood sugar levels in type 2 DM patients at A. Yani Islamic Hospital, Surabaya.
Conclusion: The conclusion of this study is discharge planning can affect the stability of blood sugar levels in patients with diabetes mellitus type 2.
Honey as Miracle Therapy for Covid-19: Literature Study
Authors: Amalia Tri Utami  , Rizqi Putri Nourma Budiarti
Published: December 2022

Due to their capacity to reduce acute inflammation by increasing the immune response, honey and its constituents are gaining attention as an efficient natural therapeutic. Studies have suggested that it may be able to treat a variety of chronic illnesses and conditions, including as bacterial and fungal infections, cardiac issues, diabetes, hypertension, and abnormalities of the lungs and heart. More significantly, honey has proven to have virucidal effects on a number of enveloped viruses, including the varicella-zoster virus, herpes simplex, influenza virus, and HIV.
Honey may help patients with COVID-19, a disorder brought on by the SARS-CoV-2 enveloped virus, by boosting the host's immune system, treating comorbid conditions, and engaging in antiviral activities. Additionally, patients with COVID-19 are presently participating in a clinical trial of honey. We've attempted to condense the possible advantages of honey and its components in this review in terms of antibacterial properties, some chronic illnesses, and the host's immune system. Therefore, we have made an effort to develop a relationship with honey in order to treat COVID-19. In light of the COVID-19 epidemic, this review will be useful in reevaluating our understanding of the potential therapeutic benefits of honey. However, more in vitro and in vivo research is required to determine the effects of honey on SARS-CoV-2 replication and/or the host's immune system.
Parental support is important to improve clean and healthy living behavior for school-age children during the COVID-19 pandemic
Authors: R. Khairiyatul Afiyah  , Ratna Yunita Sari  , Rusdianingseh  , Yurike Septianingrum  , Ika Mardiyanti  , Robi Is Maulana  , Firman Suryadi Rahman
Published: December 2022

Introduction: School-age children are a critical age group because they are vulnerable to health problems that usually arise related to clean and healthy living behavior. The purpose of this study was to determine the relationship between parental support and clean and healthy living behavior as an effort to prevent covid-19 in students of SDN 1 Panglungan Wonosalam Jombang.
Methods: Analytical research design with "cross sectional" approach. The population was 40 students from class V and VI. A sample of 37 students was taken using the Cluster Sampling technique. The instrument used a parental support questionnaire and clean and healthy living behavior. Data analysis used Spearmen Rank correlation statistical test with a significant level of = 0.05.
Results: The results of the study were obtained from 37 respondents, almost entirely (81.1%) had a good level of support and most (62.2%) had a clean and healthy lifestyle as a good covid 19 prevention effort. Spearman rank correlation test analysis obtained p value of 0.01 <0.05, then h0 is rejected and h1 is accepted.
Conclusion: There is a significant relationship between parental support and clean and healthy living behavior as an effort to prevent covid-19 in students of SDN Panglungan 1 Wonosalam Jombang. The role of nurses can provide nursing care in the form of education for children and parents, so that children are able to carry out clean and healthy living behaviors as an effort to prevent Covid-19.
Factors to accelerate the reducing stunting cases in Jombang regency, with optimal convergence actions and cross sectoral effort
Authors: Rizki Amalia  , Dini Setiarsih  , Fildzah Karunia Putri  , Paramita Viantry
Published: December 2022

Introduction: The current burden of malnutrition in Indonesia is trifold. The nutrition programme component aims to reduce the triple burden of malnutrition throughout the life cycle, through support to maternal nutrition, prevention of stunting and wasting in children under 5 years of age, nutrition for school-age children and adolescents, and overweight prevention. The purpose of this study was to determine the factors to accelerate the reducing stunting cases in Jombang regency, with optimal convergence actions and cross sectoral effort.
Methods: This study is a qualitative study with a case study approach. The study is located in 11 village in Jombang regency. This study was conducted in September-November 2021. Data collection was carried out in in 11 village in Jombang district East Java Province, Curah Malang Village, Murukan Village, Diwek Village, Rejoslamet Village, Dukuh Klopo, Pakel, Kali Kejambon, Jombatan, Sumber Mulyo, Gadingmangu, Darurejo.  
Results: The percentage of stunting in 2018 to 2021 has decreased significantly. According to data from the Bappeda of Jombang Regency on November 29, 2021, the stunting performance review activity showed that, in 2018 the number of cases in Jombang Regency was 20.1% with the number of stunting toddlers being 15,056 children, experiencing a decrease of 9.8% in 2021. The percentage of case data in 2021 is 10.3% with a total of 7,518 stunting children under five
Conclusion: The percentage of stunting in 2018 to 2021 has decreased significantly which is influenced by various factors that need to be controlled to reduce the incidence of stunting in Jombang regency.
Stress, motivation, satisfaction, and learning achievement: A case study
Authors: Widya Addiarto  , Yulia Rachmawati Hasanah
Published: December 2022

Introduction: Currently, the coronavirus (Covid-19) is still a global problem that is felt by various countries in the world, including Indonesia. The occurrence of this epidemic greatly affected all sectors of human life, one of which was in the education sector where there was a changing the learning process from face-to-face to an online learning system. The implementation of online learning turned out to have a considerable impact on students, especially nursing students, one of which was the emergence of academic stress that was felt during the learning process. This study aimed to determine the correlation between academic stress due to online learning and the motivation, satisfaction and learning achievement of nursing students during the Covid-19 pandemic.
Methods: This study uses a descriptive correlative method with a cross-sectional approach. Researchers distributed online questionnaires to 259 respondents, namely active nursing students who carried out online learning. Then the data obtained were analyzed by researchers univariately to determine the distribution and frequency distribution and bivariate test using somersd and lambda to determine the correlation of each variable with academic stress.
Results: The results showed that there was a significant correlation between age (ρ=0.001), gender (ρ=0.005), grade education (ρ=0.048), learning understanding (ρ=0.000), and academic stress while the variable of media use did not correlate with academic stress (ρ=. In addition, academic stress is also correlated with variable satisfaction (ρ=0.041), and motivation (ρ=0.002) and is not correlated with learning achievement (ρ=0.388).
Conclusions: The current Covid-19 pandemic situation has greatly impacted the teaching and learning process, especially the emergence of academic stress, and decreased motivation and learning satisfaction of nursing students. This condition will become serious if each variable that is correlated with academic stress is not handled properly.
The importance of husband support for breastfeeding during pandemic COVID-19
Authors: Mega Silvian Natalia  , Wahida Yuliana  , Bawon nulhakim
Published: December 2022

Introduction: Unachieved exclusive breastfeeding is still a problem in Indonesia. During pandemic covid-19 situation, the condition required to keep the distance from other people resulting the limited access between breastfeeding mothers and midwives. The role of the closest person that is husband is needed to constantly provide support. The objective of this research is to determine the relationship between husband's support during the covid-19 pandemic with exclusive breastfeeding
Methods: The type of research used is an analytic survey with a cross sectional method. The total population are 51 people and the sample of 45 people is taken using purposive sampling technique. Collecting data using questionnaire sheets given to respondents. Data analysis using Chi Square test (X2).
Results: Based on analysis, we found that husband’s support has a significant association with the quality of exclusive breastfeeding with p=0.000.
Conclusion: The result of the research informed husbands who want to provide support in the form of effective communication between husband and wife during the breastfeeding process, able to help breastfeeding mothers to keep the spirit of breastfeeding, and will help provide breast milk as the best food for their babies. There is a significant relationship between husband's support in the success of exclusive breastfeeding during the covid-19 pandemic.
Transcatheter aortic valve implantation: A review article
Authors: Rampengan Starry Homenta , Jansen Chitrahadinata
Published: December 2022

Aortic stenosis is a valvular heart disease commonly found in developed and developing countries. The frequency of aortic valve sclerosis is about 25% in people over 65 years of age. In contrast to developing countries, infectious diseases, such as endocarditis or rheumatic fever, contribute greatly to aortic stenosis. Severe aortic stenosis without valve replacement has a poor prognosis and some patients are at high risk for surgery. Transcatheter aortic valve implantation (TAVI) is emerging as an alternative in patients with aortic stenosis who cannot or are at high risk for surgery. TAVI has revolutionized the management of aortic stenosis. This procedure continues to improve yearly and exceeds surgical aortic valve replacement in 2019. Initially, TAVI generated skepticism and criticism, but with many clinical trials and evidence-based investigations, TAVI is now widely accepted. Until now, the development of TAVI continues, starting with better technology, approaches, and new implantation strategies; TAVI is becoming safer for patients. This literature review will discuss more deeply about TAVI and its development.
Comparative effect of incentive spirometry and diaphragm breathing to functional capacity in COVID-19 patient in an isolated ward
Authors: Amien Suharti  , Evi Rachmawati Nur Hidayati  , Yusviani Hafizia Asri
Published: December 2022

Background: COVID-19 affects the multiorgan system, mostly the respiratory system. Symptoms might vary from upper respiratory manifestation to acute respiratory distress syndrome, with the main feature being impairment of gas exchange. This pulmonary impairment might lead to a decrease in functional capacity, which cause activity limitation. Thus, COVID-19 patient requires the right pulmonary rehabilitation strategy to improve pulmonary function and prevent further pulmonary complications. This study aimed to compare the effectiveness of incentive spirometry and diaphragm breathing exercise on cardiorespiratory functional capacity in COVID-19 patients.
Methods: Subjects were divided into two groups of breathing exercises, the incentive spirometry group and the diaphragm breathing exercise group. They performed breathing exercises for 5 days, and the functional capacity was measured by a test named 4-meter gait time test (4MGT) and 30 sit-to-stand test (30STS). The test was taken before and after performing breathing exercises.
Results: These two respiratory exercises significantly affected the functional capacity in a good manner (p < 0.05). The incentive spirometry had improved 30STS (P = 0.763) and 4MGT results (P = 0.674), as well as diaphragm breathing exercise did to 30STS (P = 0.456) and 4MGS (P = 0.441).
Conclusion: In conclusion, diaphragm breathing exercises and incentive spirometry improved the functional capacity of COVID-19 patients. However, incentive spirometry showed a larger effect on 30STS and 4MGT compared to diaphragm breathing exercises.
Supplementation in suppressing Troponin I and NT-proBNP level in breast cancer patients with 5- fluorouracil, adriamycin, and cyclophosphamide chemotherapy
Authors: Dharma Stefanus Satria Adi , Budijitno Selamat , Sofia Sefri Noventi
Published: December 2022

Background: Breast cancer is a malignancy originating from breast tissue, where chemotherapy is one of the choice therapy. Doxorubicin, 5-fluorouracil, and cyclophosphamide (FAC) are the most commonly used combination of chemotherapy. One of the side effects of chemotherapy is cardiotoxicity. Multiflora honey prevents cardiotoxic effects through its flavonoids and polyphenols compounds. The aim of this research is to analyze the effectiveness of adding honey in preventing cardiotoxic effects in breast cancer patients receiving FAC chemotherapy.
Methods: An experimental study with double-blind randomized pre and post-test with control group design. Ductal invasive breast cancer patients were divided into 2 groups, the control group, who received FAC chemotherapy (n=18) and the treatment group, who received chemotherapy and 90 ml/day honey consumption for 14 days (n=18). The patient's Troponin I and NT-proBNP enzyme levels before and after 14 days of the study were assessed.
Results: Post-treatment, there was an increase in Troponin I levels from the treatment group (0.22 ± 0.07 vs. 0.24 ± 0.07) vs. control (0.25 ± 0.11 vs. 0.34 ± 0.20) with a significant difference. (p = 0.031). There was a decrease in NT-proBNP levels in the treatment group (461.0 ± 610.4 vs. 215.6 ± 260.3) and an increase in NT-proBNP levels (275.9 ± 392.4 vs. 315.4 ± 293.9) with a significant difference (p = 0.006).
Conclusion: Multiflora honey can prevent cardiotoxic effects in breast cancer patients receiving FAC chemotherapy.
Grape (Vitis vinifera L.) skin extract reduced levels of SGPT and SGOT and improved the liver tissue structure of Wistar rats (Rattus novergicus) fed a high-cholesterol diet
Authors: Siti Maryam  , Ni Kadek Alit Arsani  , Sartika Tangguda
Published: December 2022

Background: This study determined the effect of adding grape skin extract (Vitis vinifera L.) to the diet of Wistar rats fed with high cholesterol on levels of SGPT and SGOT and the structure of liver tissue.
Methods: This study used 5 groups, namely control (standard diet), P1 (high cholesterol diet), P2 (high cholesterol diet and extract of grape skin as much as 100 mg/200 gBW/day), P3 (high cholesterol diet and extract of grape skin as much as 250 mg/200 gBW/day) and P4 (high cholesterol diet and extract of grape skin 500 mg/200 gBW/day). The study began with the production of extracts, the extracts dosage determination, high cholesterol diet preparation, sample (animals) preparation, extract addition to animals, SGPT and SGOT levels measurement, rat liver histopathology preparation and histopathological features observation, then ended with data analysis.
Results: The results showed that administration of grape skin extract in Wistar rats fed a high-cholesterol diet affected the levels of SGPT and SGOT, as well as parenchymatous degeneration of hepatocytes. Administration of grape skin extract as much as 500 mg/200 g BW/day had the lowest mean levels of SGPT and SGOT and the lowest parenchymatous degeneration of hepatocytes.
Conclusion: Thus, the extract of grape skin (Vitis vinifera L.) has the potential of hepatoprotector because it contains anthocyanin, which functions as an antioxidant and protects against liver damage.
Effect of tartrazine on blood urea nitrogen, creatinine levels, and renal tubular necrosis in adult male Wistar rats (Rattus norvegicus): an experimental study
Authors: Rahayu Mulyati Sri , Wahyuni Sri , Fitriani Idha , Agung Habib Budiman
Published: December 2022

Introduction: Tartrazine is still one of the most widely used coloring agents in the pharmaceutical, cosmetic, and food industries; various hazardous consequences have been identified in rodents and humans, including impaired kidney function. This current study aimed to evaluate the effect of tartrazine on the biochemical parameters and structures of the kidney.
Methods: Twenty-four adult male Wistar rats were divided into four groups of 6 each. The experimental animals received tartrazine orally at a dose of 3.75, 7.5, and 15 mg/kg body weight along with a normal diet. The control group received only food and drinking water. The study was carried out for 21 days. At the end of the experiment, biochemical (blood urea nitrogen and serum creatinine) and histopathological examinations were performed on animal kidney tissues.
Results: Our findings revealed a significant increase in urea and creatinine levels in the serum of tartrazine-treated rats compared to controls (p < 0.05). The kidney section of rats treated with tartrazine showed lumen compression of tubular cells and loss of integrity of the renal tubule membrane. Tartrazine was associated with increases in the percentage of renal tubular necrosis in a dose-dependent manner compared to the control group (p < 0.05).
Conclusions: The current study concluded that oral administration of tartrazine affected the kidney by increasing urea nitrogen, creatinine levels, and the percentage of renal tubular necrosis in male Wistar rats. The results showed that tartrazine intake could cause adverse kidney health effects.
A study of efficacy, safety, and acceptance of two combined oral contraceptive pills containing 150 mcg Levonorgestrel and 30 mcg Ethinyl Estradiol at Dr. Kariadi Hospital, Semarang, Indonesia
Authors: Hidayat Syarief Thaufik , Tjahjanto Hary , Eria Robert , Gozali Yenny Kartika
Published: December 2022

Background: Combine Oral Contraceptives (COCs) pills is one of the many popular contraceptives worldwide, with 100 million women who use contraceptive pills. To increase the choice of oral contraceptives, COCs Novadiol® (Pill A) domestic production, which has the same dosage as Microgynon® (Pill B), are still imported drugs. This study aims to determine Pill A's efficacy, safety and acceptance level compared to Pill B for 3 months.
Methods: The study was a randomized control clinical trial, an open-label trial in 200 women of childbearing age who met the inclusion and exclusion criteria from July to November 2015. Data were analyzed using SPSS version 20 for Windows.
Results: About 300 participants were selected and 200 met the inclusion and exclusion criteria who participated study from the beginning to the end of the study period. In the first month of observation, 1 complaint of dizziness in pill A and 2 from pill B. One nausea complaint was found in the participant from Pill A. These differences were not statistically significant (p>0.05). In the second month of observation, 1 complained of dizziness from pill B and 1 nausea from Pill A. In the third month, observation found no complaints about using Pill A and pill B. There were changes in menstrual patterns in both pills and bleeding outside the cycle during the use of 3 months, but they were not statistically significant (p>0.05).
Conclusion: Pills A has the same efficacy, safety and acceptance when compared to the use of birth control pills B for 3 months.
Peripheral blood abnormality in Sezary Syndrome with bacteremia
Authors: Mellaratna Wizar Putri , Zubir  , Sahputri Juwita , Irwandi
Published: December 2022

Introduction: Sezary syndrome defined as a set of symptoms consist of erythroderma, generalized lymphadenopathy, and Sezary cells were detected in peripheral blood, skin and lymph nodes.
Case: Patients with chief complaints red and scaly patches cover almost part of the body accompanied by itching since 1 week ago. The patient had history of taking herbal medicines 2 weeks earlier. There is an erosion and crusting at inferior lips. There is also fissure at left side ventral hand region. There is no generalized lymphadenopathy. The patient has fever, hypertension and hyperglycemia. The laboratory result showed leukocytosis with Sezary cells > 1000 cells/mm3, and bacteremia (coccus). Differential diagnosis of patients was Sezary syndrome, drug-induced erythroderma and mycosis fungoides. The diagnosis was Sezary syndrome because erythroderma and Sezary cells > 1000 cells/ mm3 were found. The patient was treated with injection of corticosteroid, antibiotic, barrier repair moisturizer and potent topical corticosteroid.
Conclusion: Sezary syndrome is often accompanied by bacteremia due to impaired skin barrier function and decreased cellular immunity. Examination of biopsy, bacterial culture and flow cytometer is required for diagnosis.
Fibrin glue as a novel therapy for contracted socket in comparison to mitomycin-c and triamcinolone acetonide at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Authors: Muthie Firda Ayu , Komaratih Evelyn , Sutjipto  , Fauziah Dyah , Utomo Budi
Published: December 2022

Background: Contracted socket is still a major problem for patients with anophthalmia. The main factor for this condition is inflammation and fibrosis, which result in conjunctival shortening. Myofibroblasts that express α-SMA are the primary mediators of anophthalmic socket contraction.
Methods: One healthy eye of a New Zealand white rabbit were randomly selected for evisceration and divided into four treatment groups, each with five rabbits. Each rabbit in the group received a single subconjunctival injection of a different agent. Group, I was the control group that received no injection, Group II received MMC 0.4 mg/ml, Group III received TCA 40 mg/ml, and Group 4 received fibrin glue. After 14 days, the animals were euthanized, and conjunctival samples were submitted for histopathological analysis. A monoclonal α-SMA antibody was applied, and pathologists provided the IRS score for each sample. The differences in α-SMA expression were statistically analyzed with a significant level of p <0.05
Result: All groups displayed a statistically significant decrease in α-SMA expression compared to the control group (p<0.05) as sorting as MMC group with p=0.007, TCA group with p=0.007, and fibrin glue with p= 0.009. MMC was the most effective at reducing α-SMA (p=0.004). Surprisingly, there were no statistically significant differences between MMC, TCA, and fibrin glue when they were evaluated independently.
Conclusion: A single subconjunctival injection of fibrin glue may be used as a novel treatment to prevent socket contracture in actively healing sockets.