bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Varying H2S Content on High-Temperature Corrosion of Ferritic and Austenitic Alloys in a Simulated Pyrolysis Process of Post-Consumer Plastics
Authors: Nimmervoll Manuela , Mori Gregor , Bucher Edith , Hönig Stefan , Haubner Roland
Published: June 2021

The alloys K90941 and N08811 were tested under conditions simulating a pyrolysis process of post-consumer plastics. Impurities in the plastic feedstock like chlorine containing materials or organic components yield HCl and H2S respectively during the cracking process. The reactor material must be able to withstand these harsh corrosive conditions.

In lab-scale test equipment, process conditions of the reactor zone of the pyrolysis process were simulated at temperatures of 420 °C and 580 °C for 72 h. The gas atmosphere consisted of either 200 ppm or 20000 ppm H2S and 3.8 vol% HCl, 1.9 vol% CO2, 0.3 vol% CO, 2.8 vol% H2, bal. N2. After the corrosion experiments, the samples were analyzed by metallography, SEM/EDX, and XRD. Additionally, the mass loss was evaluated. Results show that the ferritic K90941 is more aggressively attacked than the austenitic N08811 and that for both materials the mass loss rises with increasing H2S content in the gas atmosphere and increasing temperature.
On nonlocal minimal graphs
Authors: Cozzi Matteo , Lombardini Luca
Published: June 2021

We develop a functional analytic approach for the study of nonlocal minimal graphs. Through this, we establish existence and uniqueness results, a priori estimates, comparison principles, rearrangement inequalities, and the equivalence of several notions of minimizers and solutions.
Application of Artificial Neural Networks for Predicting the Bearing Capacity of Shallow Foundations on Rock Masses
Authors: Millán M. A. , Galindo R. , Alencar A.
Published: June 2021

Calculation of the bearing capacity of shallow foundations on rock masses is usually addressed either using empirical equations, analytical solutions, or numerical models. While the empirical laws are limited to the particular conditions and local geology of the data and the application of analytical solutions is complex and limited by its simplified assumptions, numerical models offer a reliable solution for the task but require more computational effort. This research presents an artificial neural network (ANN) solution to predict the bearing capacity due to general shear failure more simply and straightforwardly, obtained from FLAC numerical calculations based on the Hoek and Brown criterion, reproducing more realistic configurations than those offered by empirical or analytical solutions. The inputs included in the proposed ANN are rock type, uniaxial compressive strength, geological strength index, foundation width, dilatancy, bidimensional or axisymmetric problem, the roughness of the foundation-rock contact, and consideration or not of the self-weight of the rock mass. The predictions from the ANN model are in very good agreement with the numerical results, proving that it can be successfully employed to provide a very accurate assessment of the bearing capacity in a simpler and more accessible way than the existing methods.
Large-scale physical modelling of static liquefaction in gentle submarine slopes
Authors: Maghsoudloo Arash , Askarinejad Amin , de Jager Richard R. , Molenkamp Frans , Hicks Michael A.
Published: June 2021

Planning a monitoring campaign for a natural submarine slope prone to static liquefaction is a challenging task due to the sudden nature of flow slides. Therefore, gaining a better insight by monitoring the changes in pore pressure and acceleration of the soil mass, prior to and at the onset of static liquefaction, of submerged model slopes in the laboratory, helps in quantifying the minimum required triggering levels and ultimately the development of effective margins of safety for this specific failure mechanism. This study presents a set of physical model tests of submarine flow slides in the large-scale GeoTank (GT) of Delft University of Technology, in which a tilting mechanism was employed to trigger static liquefaction in loosely packed sand layers. Novel sensors were developed to locally monitor the hydro-mechanical soil responses acting as precursors of the onset of instability. The measurements indicated that soil instability can initiate at overly gentle slope angles (6–10°) and generate significant excess pore water pressures that intensify the deformations to form a flow slide. Moreover, it was observed that the onset of instability and its propagation are highly dependent on the rate of shear stress change and the state of the soil. The obtained data can be used for the future validation of numerical models for submarine flow slides.
Green, blue or black, but washing–What company characteristics determine greenwashing?
Authors: Ruiz-Blanco Silvia , Romero Silvia , Fernandez-Feijoo Belen
Published: June 2021

The purpose of this paper is to study what are the characteristics that make firms less or more prone to greenwashing. We collect data from sustainability disclosures of the S&P top 100 companies, to investigate the determinants of greenwashing. We use content analysis to measure the level of reporting of the companies. We define the “greenwashing” variable as the difference between what the company says it does in terms of commitment to sustainability, and what the company actually does as evaluated by external parties (Bloomberg ESG scores). Our results show that companies in environmentally sensitive industries greenwash less than their counterparts in other industries, as well as companies following the GRI guidelines. Companies that issue a sustainability report and assure it greenwash less than those that do not do it. Contrary to our intuition, companies in industries with close proximity and high visibility greenwash more than their counterparts. A limitation of the paper is the inclusion in the sample of data from one country. Our findings have implications for policy-makers, particularly in Europe, where some European states have already regulated on green issues reporting and lately on blue issues. It might be interesting to consider both the industry effect and the relevance of reporting mechanisms when developing regulation and policies in order to improve the quality of sustainability reporting. We contribute to literature by proposing a new quantitative measure to assess greenwashing practices, to better understand the effect of industry and reporting mechanisms on greenwashing.
Investigations on historical monuments’ deterioration through chemical and isotopic analyses: an Italian case study
Authors: Ricciardi Maria , Pironti Concetta , Motta Oriana , Fiorillo Rosa , Camin Federica , Faggiano Antonio , Proto Antonio
Published: June 2021

In this paper, we analysed the efflorescences present in the frescos of a monumental complex named S. Pietro a Corte situated in the historic centre of Salerno (Campania, Italy). The groundwater of the historic centre is fed by two important streams (the Rafastia and the Fusandola) that can be the sources of water penetration. The aims of this work are to (i) identify the stream that reaches the ancient frigidarium of S. Pietro a Corte and (ii) characterize the efflorescences on damaged frescos in terms of chemical nature and sources. In order to accomplish the first aim, the water of the Rafastia river (7 samples) and the water of the Fusandola river (7 samples) were analysed and compared with the water of a well of the Church (7 samples). The ionic chromatography measurements on the water samples allowed us to identify the Rafastia as the river that feeds the ancient frigidarium of S. Pietro a Corte. To investigate the nature and the origin of the efflorescences (our second aim), anionic chromatography analyses, X-ray diffraction measurements, and the isotopic determination of nitrogen were performed on the efflorescences (9 samples) and the salts recovered from the well (6 samples). Results of these analyses show that efflorescences are mainly made of potassium nitrate with a δ15N value of + 9.3 ± 0.2‰. Consequently, a plausible explanation for their formation could be the permeation of sewage water on the walls of the monumental complex.
ABO blood group system and risk of positive surgical margins in patients treated with robot-assisted radical prostatectomy: results in 1114 consecutive patients
Authors: Porcaro Antonio Benito , Amigoni Nelia , Migliorini Filippo , Rizzetto Riccardo , Tafuri Alessandro , Piccoli Pierluigi , Tiso Leone , Cerrato Clara , Bianchi Alberto , Gallina Sebastian , Orlando Rossella , De Michele Mario , Gozzo Alessandra , Antoniolli Stefano Zecchini , De Marco Vincenzo , Brunelli Matteo , Cerruto Maria Angela , Artibani Walter , Siracusano Salvatore , Antonelli Alessandro
Published: June 2021

To test the hypothesis of associations between the ABO blood group system (ABO-bg) and prostate cancer (PCa) features in the surgical specimen of patients treated with robot-assisted radical prostatectomy (RARP). Between January 2013 and October 2020, 1114 patients were treated with RARP. Associations of ABO-bg with specimen pathological features were evaluated by statistical methods. Overall, 305 patients were low risk (27.4%), 590 intermediate risk (50%) and 219 high risk (19.6%). Pelvic lymph node dissection was performed in 678 subjects (60.9%) of whom 79 (11.7%) had cancer invasion. In the surgical specimen, tumor extended beyond the capsule in 9.8% and invaded seminal vesicles in 11.8% of cases. Positive surgical margins (PSM) were detected in 271 cases (24.3%). The most frequently detected blood groups were A and O, which were equally distributed for both including 467 patients (41.9%), followed by groups B (127 cases; 11.4%) and AB (53 subjects; 4.8%). Among specimen factors, the ABO-bgs associated only with the risk of PSM, which was higher for blood group O (30.4%) compared with group A (19.5%) after adjusting for other standard clinical predictors (odds ratio, OR = 1.842; 95% CI 1.352–2.509; p < 0.0001). Along the ABO-bgs, the risk of PSM was increased by group O independently by other standard preoperative factors. The ABO-bgs may represent a further physical factor for clinical assessment of PCa patients, but confirmatory studies are required.
Comparison of floral traits in Calibrachoa cultivars and assessment of their impacts on attractiveness to flower-visiting insects
Authors: Marquardt Melanie , Kienbaum Lydia , Losert Dominik , Kretschmer Lea Annina , Rigling Marina , Zhang Yanyan , Schweikert Karsten , Westermann Nils , Ruttensperger Ute , Rosenkranz Peter
Published: June 2021

Ornamental plants are appreciated by humans for their colorfulness, beauty, abundant flowering and long blooming periods. Many ornamental plants can also constitute an additional foraging resource for flower-visiting insects. However, the ability of the popular ornamental plant Calibrachoa to support urban insect communities is not well documented. In this study, 20 different Calibrachoa cultivars were selected and tested in regard to their insect friendliness based on standardized observations (I) in flight tents using the large earth bumble bee Bombus terrestris as a model species and (II) in open field trials. To investigate what floral characteristics might constitute attractiveness to bumble bees, various floral traits were recorded and compared across all tested Calibrachoa cultivars. Over a two-year period, a total of 6,327 foraging bumble bees were recorded in the tent observations. In the open field observations, we counted 4,188 flower-visiting insects. Our results revealed that (I) all Calibrachoa cultivars were visited by insects for foraging, (II) the number of insect visitors varied significantly among the 20 tested cultivars and (III) the cultivars displayed different floral traits. For the morphometric floral traits and the aroma profiles of Calibrachoa, only the mean nectar quantity and a few identified compounds could be correlated with attractiveness to the model species B. terrestris. We also found that the petal color of the tested cultivars had a significant impact on the number of visitors. Therefore, B. terrestris clearly preferred red or blue Calibrachoa cultivars over those with other petal colors. However, as the cultivar preferences in the different insect groups differed, it is highly recommended to use various cultivars in urban plantings. Nevertheless, efforts must be made to explain what additional floral traits make Calibrachoa and other ornamental plants generally attractive to flower visitors. This information can then be used for breeding purposes to increase the insect friendliness of ornamental plants.
Kindeswohl in der Krise?
Authors: Kläsener Nina
Published: June 2021

Der Verdacht auf Kindeswohlgefährdung stellt die sozialpädagogische Professionalität in zunehmendem Maße vor die Herausforderung, Gefährdungslagen von Kindern und Jugendlichen einzuschätzen und Entscheidungen zu treffen. Der Beitrag diskutiert Entscheidungslogiken am Instrument des Schutzplans.
Vegetation Diversity of Screes and Taluses of The Pamir and South-Western Tian Shan in Middle Asia
Authors: Nowak Arkadiusz , Świerszcz Sebastian , Nowak Sylwia , Nobis Marcin
Published: June 2021

This paper presents the results of phytosociological research on scree vegetation of the Pamir and south-western Tian Shan. We collected 222 phytosociological relevés during field studies conducted in 2015–2019, applying the Braun-Blanquet approach. We identified 21 plant communities on mobile and stabilized screes of colluvial cones, aprons and fans, inhabiting mainly the montane and alpine belts in several ranges (e.g. Peter the First, Alichur, Shugnan, Shachdarian, Darvaz, Rushan, Vanch, Fergana, Kyrgyz and Terskey ranges). As a result we provide the first comprehensive hierarchical syntaxonomic synopsis of scree communities at montane and alpine elevations in the eastern Middle Asia. The collected vegetation relevés represent the majority of the variation among the phytocoenoses of gravel, pebble, cobble and rock block slides and screes in the montane and alpine belts. As a result of field studies and Twinspan analyses, nine associations were identified on screes of the Pamir and western Tian Shan. All these communities were assigned to the Sileno brahuicae-Lactucetalia orientalis Nowak et al. 2021. Additionally, within the nitrophilous compact gravel screes one subassociation of Corydalidetum kashgaricae trigonelletosum gontscharovii was distinguished. In the most arid zone two additional plant associations and one subassociation were identified in gravelly semi-deserts zone. The main factors determining the species composition of the studied associations are scree mobility, rock particle size, elevation above sea level and slope inclination. Our research revealed considerable diversity of scree habitats of montane and alpine belts what might be astonishing regarding harsh environment of this mountainous territory. However, a great number of lineages that evolved here and particularly rich species pool of this habitat in Middle Asia facilitate remarkable diversity among vegetation of taluses and screes. The distinctiveness of species composition is additionally enhanced by high degree of endemism of chasmophytic habitats in the eastern part of Middle Asia. Despite recent developments, the prominent chasmophytic vegetation of Middle Asia still needs thorough studies focused on its relationship to semi-desert, tall-forb and petrophytic communities of high mountains of the Pamir, Hindu-Kush, Kunlun and Central Tian Shan.
Building Structural Empathy to Marshal Critical Education into Compassionate Practice: Evaluation of a Medical School Critical Race Theory Course
Authors: Tsai Jennifer
Published: June 2021

Ideas of racial genetic determinism, though unsupported by scientific evidence and atavistic, are common and readily apparent in American medical education. These theories of biologic essentialism have documented negative effects in learners, including increased measures of racial prejudice.
Provide Vaccines, Not Require Immunity or Vaccination Passports … For Now
Authors: Savulescu Julian
Published: June 2021

In principle, mandatory vaccination in employment could be justified in certain circumstances. These include: (1) the availability of safe and effective vaccination; (2) if alternative, less coercive strategies did not work; and, (3) the costs to the individual were proportionate. However, in COVID-19, the long term safety of vaccines is yet to be established. Vaccines should be made available by employers, and voluntary vaccination encouraged.
Architectural Network as Dynastic Strategy in Fontainebleau's Galerie des Cerfs
Authors: Narkin Elisabeth
Published: June 2021

Around 1604, Henri IV commissioned a cycle of mural maps depicting royal residences in Fontainebleau's newly constructed Galerie des Cerfs. The gallery was part of Henri IV's response to the dynastic disruption and civil war that had precipitated his ascendance and was designed to signal his authority over France as a unified realm. This article examines the Galerie des Cerfs in the context of contemporary cartography and architecture as an expression of continuity at a moment when the royal family's retreat to the Paris region threatened the political efficacy of the architectural network that had previously sustained the monarchy.
Rancor: Sephardi Jews, Spanish Citizenship, and the Politics of Sentiment
Authors: McDonald Charles A.
Published: June 2021

In 2015, Spain approved a law that offered citizenship to the descendants of Sephardi Jews expelled in 1492. Drawing on archival, ethnographic, and historical sources, I show that this law belongs to a political genealogy of philosephardism in which the “return” of Sephardi Jews has been imagined as a way to usher in a deferred Spanish modernity. Borrowing from anthropological theories of “racial fusion,” philosephardic thinkers at the turn of the twentieth century saw Sephardi Jews as inheritors of a racial mixture that made them living repositories of an earlier moment of national greatness. The senator Ángel Pulido, trained as an anthropologist, channeled these intellectual currents into an international campaign advocating the repatriation of Sephardi Jews. Linking this racial logic to an affective one, Pulido asserted that Sephardi Jews did not “harbor rancor” for the Expulsion, but instead felt love and nostalgia toward Spain, and could thus be trusted as loyal subjects who would help resurrect its empire. Today, affective criteria continue to be enmeshed in debates about who qualifies for inclusion and are inextricable from the histories of racial thought that made earlier exclusions possible. Like its precursors, the 2015 Sephardic citizenship law rhetorically fashioned Sephardi Jews as fundamentally Spanish, not only making claimsaboutSephardi Jews, but also making claimsonthem. Reckoning with how rancor and other sentiments have helped buttress such claims exposes the recalcitrant hold that philosephardic thought has on Spain's present, even those “progressive” political projects that promise to “return” what has been lost.
The effect of increased temperature and CO2 air enrichment on the nutritive value of orchard grass (Dactylis glomerata) in permanent grassland
Authors: Küsters J. , Pötsch E. M. , Resch R. , Gierus M.
Published: June 2021

High yielding ruminant livestock require high nutritive value in forage for maintenance, growth and production. Climate change has been documented as impacting on the nutritive value of forage plants. Therefore, the aim of this study was to investigate the impact of increased temperature in combination with CO2-enhancement on the nutritive value of orchard grass (cocksfoot; Dactylis glomerata L.), as a C3 model plant, widespread in mountainous permanent grassland plant communities. Functional traits and forage quality of orchard grass were investigated both under ambient (C0T0) and under simulated, future climate conditions (C2T2) with increased temperature (+3°C) and enhanced CO2 concentration (+300 ppm) under field conditions. Plant samples were taken from each of the three growths over a period of three consecutive years and numerous functional properties and forage quality parameters were determined. Special attention was paid to the determination of water-soluble carbohydrates (WSC), crude protein (CP), non-protein N (NPN) and metabolizable energy (ME) as possible indicators for different climatic conditions. It is hypothesized that (i) functional traits and (ii) forage quality of orchard grass are altered by increased temperature and higher CO2 concentration. The results showed a negative impact of C2T2 compared to C0T0 on tiller height (54.4 v. 70.6 cm) and weight (2.42 v. 3.22 g) as average over cuts and years. The NPN content was lower in C2T2 (312 g/kg CP) compared to C0T0 (339 g/kg CP). In contrast, the WSC content was higher in C2T2 (90.3 g/kg DM) compared to C0T0 (82.5 g/kg DM). Both ME content and digestibility were increased in C2T2 (9.18 ME/kg DM and 68.2%) compared to C0T0 (8.86 ME/kg DM and 65.4%). Concluding, under increased temperature and enhanced CO2, both functional traits and certain nutrients and their fractions appear to change in orchard grass.
China, Europe, and the Great Divergence: A Restatement
Authors: Broadberry Stephen , Guan Hanhui , Li David Daokui
Published: June 2021

Peter Solar highlights some shortcomings of our treatment of government spending. However, correcting for these shortcomings using data rather than assumptions confirms our principal findings. GDP per capita in the leading region of China remained around the same level as in the leading region of Europe until the eighteenth century before declining substantially during the Qing dynasty. The Great Divergence thus began around 1700, earlier than originally suggested by the California School, but later than implied by earlier writers. The new data do not support Solar’s novel chronology with its Great Crossing, Great Convergence and Greater Divergence.
Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?
Authors: Vaira L A , De Vito A , Deiana G , Pes C , Giovanditto F , Fiore V , Lechien J R , Saussez S , Policicchio D , Boccaletti R , Madeddu G , Babudieri S , Pazzola A , Bandiera F , Fois A G , Piana A F , Hopkins C , De Riu G
Published: June 2021

Objective

To analyse the correlations between olfactory psychophysical scores and the serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients.

Methods

Patients underwent psychophysical olfactory assessment with the Connecticut Chemosensory Clinical Research Center test, and determination of blood serum levels of the inflammatory markers D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio within 10 days of the clinical onset of coronavirus disease 2019 and 60 days after.

Results

Seventy-seven patients were included in this study. D-dimer, procalcitonin, ferritin and neutrophil-to-lymphocyte ratio correlated significantly with severe coronavirus disease 2019. No significant correlations were found between baseline and 60-day Connecticut Chemosensory Clinical Research Center test scores and the inflammatory markers assessed.

Conclusion

Olfactory disturbances appear to have little prognostic value in predicting the severity of coronavirus disease 2019 compared to D-dimer, ferritin, procalcitonin and neutrophil-to-lymphocyte ratio. The lack of correlation between the severity and duration of olfactory disturbances and serum levels of inflammatory markers seems to further suggest that the pathogenetic mechanisms underlying the loss of smell in coronavirus disease 2019 patients are related to local rather than systemic inflammatory factors.
Afforestation, Propaganda, and Agency: The case of Hangzhou in Mao's China
Authors: HE QILIANG
Published: June 2021

This article examines the afforestation movement in the West Lake area in Mao's China (1949–1976). I argue that this campaign was, by its nature, propagandistic, for it created a narrative of a deforested China before 1949 and a greener land after 1949 to serve the purpose of justifying China's new political system and popularizing socialist ideologies. Hence, such projects helped to define what socialism was in China and thereby solicited the participation of the general population. This afforestation project, engineered to legitimize the Chinese Communist Party's (CCP) rule in China both domestically and internationally, was, however, marred by both human and non-human actors. Local inhabitants who were intent upon protecting their own private properties vis-à-vis the collectivizing state, poachers who illegally felled trees for firewood and timber, and tea growers who were keen on expanding their tea plantations at the cost of mountain forests sabotaged the CCP's afforestation efforts. Meanwhile, various pests contributed to the massive death of newly planted trees and prompted local cadres and citizens to adjust afforestation policies throughout Mao's times. I argue that human and non-human actors possessed non-purposive agency—that is, agency not driven by their intentions and purposes but defined by their actions—to affect, deflect, and undercut the CCP's political agendas.
Know Your Rights: The (un)making of the colonial legal subjects in rural North India, circa 1770–1857
Authors: FEI DU
Published: June 2021

This article examines the entanglement of administration, education, and law in North India under early British rule. While there exists extensive discussion on each of these three themes, historians have not paid enough attention to the processes in which, by the mid-nineteenth century, the official minds of the East India Company gradually came to imagine its revenue administration in North India at the institutional intersection of state bureaucracy, village schools, and the law courts. I will argue in this article that through this intersection of knowledge/law-making, the Company wished to foster an ‘enlightened’ but simultaneously obedient subjecthood among the Indian rural population. The contested relationship between the state, the local Indian officials, and the villagers in general, however, thwarted this patronizing ambition.
The problems with delay discounting: a critical review of current practices and clinical applications
Authors: Bailey Allen J. , Romeu Ricardo J. , Finn Peter R.
Published: June 2021

Delay discounting paradigms have gained widespread popularity across clinical research. Given the prevalence in the field, researchers have set lofty expectations for the importance of delay discounting as a key transdiagnostic process and a ‘core’ process underlying specific domains of dysfunction (e.g. addiction). We believe delay discounting has been prematurely reified as, in and of itself, a core process underlying psychological dysfunction, despite significant concerns with the construct validity of discounting rates. Specifically, high delay discounting rates are only modestly related to measures of psychological dysfunction and therefore are not ‘core’ to these more complex behavioral problems. Furthermore, discounting rates do not appear to be specifically related to any disorder(s) or dimension(s) of psychopathology. This raises fundamental concerns about the utility of discounting, if the measure is only loosely associated with most forms of psychopathology. This stands in striking contrast to claims that discounting can serve as a ‘marker’ for specific disorders, despite never demonstrating adequate sensitivity or specificity for any disorder that we are aware of. Finally, empirical evidence does not support the generalizability of discounting rates to other decisions made either in the lab or in the real-world, and therefore discounting rates cannot and should not serve as a summary measure of an individual's decision-making patterns. We provide recommendations for improving future delay discounting research, but also strongly encourage researchers to consider whether the empirical evidence supports the field's hyper-focus on discounting.
The politics of GCSE English Language
Authors: Verhoeven Babette
Published: June 2021

In 2015, England saw the introduction of a new GCSE English Language, as part of changes to the National Curriculum (NC). At the time, concerns about and protests against the proposed new GCSE English Literature were widely reported (Kennedy, 2014; Tickle, 2013), while the proposed new GCSE English Language attracted less popular attention and criticism. However, GCSE Results Day on the 22nd of August 2019 saw criticism about English Language taking centre stage (Andrews, 2019; Leedham, 2019). The main concerns are that:

1.

the exams for GCSE English Language are too difficult for a significant number of students, without any real alternative English qualification on offer;

2.

students aged 16–19 who fail to achieve at least a Grade 4 (pass) are required to re-take their GCSE English Language;

3.

the repetitive, narrow focus of the GCSE English Language course itself means that significantly fewer students are taking up English Language at A level (Leedham, 2019; Whittaker, 2019).
Enough is too much: the excessiveness objection to sufficientarianism
Authors: Knight Carl
Published: June 2021

The standard version of sufficientarianism maintains that providing people with enough, or as close to enough as is possible, is lexically prior to other distributive goals. This article argues that this is excessive – more than distributive justice allows – in four distinct ways. These concern the magnitude of advantage, the number of beneficiaries, responsibility and desert, and above-threshold distribution. Sufficientarians can respond by accepting that providing enough unconditionally is more than distributive justice allows, instead balancing sufficiency against other considerations.
I, Trolley: Self-Redirection and Hybrid Trolley Cases
Authors: Locke Dustin
Published: June 2021

While it is permissible to switch the trolley in the classic Switch case, it is not permissible to push the stranger in the classic Footbridge (aka, ‘Push’) case. But what may we do in cases that offer both a ‘switch-like’ option and a ‘push-like’ option? Surprisingly, we may choose the push-like option, provided that it has better consequences than the switch-like option. We arrive at this conclusion by taking ourselves seriously – not just as agents who might redirect threats – but as threats who might be redirected by agents.
Atom Probe Tomography Investigations of Ag Nanoparticles Embedded in Pulse-Electrodeposited Ni Films
Authors: Jun Hosun , Jang Kyuseon , Jung Chanwon , Choi Pyuck-Pa
Published: June 2021

Atomic mapping of nanomaterials, in particular nanoparticles, using atom probe tomography (APT) is of great interest, as their properties strongly depend on shape, size, and composition. However, APT analyses of nanoparticles are extremely challenging, and there is an urgent need for developing robust and universally applicable sample preparation methods. Herein, we explored a method based on pulse electrodeposition to embed Ag nanoparticles in a Ni matrix and prepare APT specimens from the resulting composite film. By systematically varying the duty cycle during pulse electrodeposition, the dispersion and number density of the nanoparticles within the matrix was significantly enhanced as compared to DC electrodeposition. Several Ag nanoparticles were analyzed with APT from such samples. Shape distortions and biased compositions were observed for the Ag nanoparticles after applying a standard data reconstruction protocol. Numerical simulations of the field evaporation process showed that such artifacts were caused by a difference in the evaporation field of Ni and Ag and a local magnification effect. We expect such detrimental effects to be mitigated by a careful selection of the matrix material, matching the evaporation field of the nanoparticles. Furthermore, we anticipate that the method presented herein can be extended to a wider range of nanomaterials.
James Croll – a man ‘greater far than his work’
Authors: EDWARDS Kevin J. , ROBINSON Mike
Published: June 2021

Popular and scholarly information concerning the life of James Croll has been accumulating slowly since the death in 1890 of the self-taught climate change pioneer. The papers in the current volume offer thorough assessments of topics associated with Croll's work, but this contribution seeks to provide a personal context for an understanding of James Croll the man, as well as James Croll the scholar of sciences and religion. Using archival as well as published sources, emphasis is placed upon selected components of his life and some of the less recognised features of his biography. These include his family history, his many homes, his health, participation in learned societies and attitudes to collegiality, financial problems including the failed efforts to secure a larger pension, and friendship. Life delivered a mixture of ‘trials and sorrows’, but it seems clear from the affection and respect accorded him that many looked upon James Croll as a ‘man greater far than his work’.
Rejecting Non-Paternalist Motivation: An Experimental Test
Authors: Chen Xianwen , Schøyen Øivind
Published: June 2021

Is people’s willingness to implement their fairness views on a group dependent on how many in the group share their view? We designed a new experiment to answer this question. Spectator participants were asked how many other participants they believe share their view of whether it is fair to redistribute income in a work task. They were then given the option to pay two cents to implement the distribution they found fair upon a pair of participants who had completed the work task. Although spectator participants systematically overestimate how many share their fairness view, being informed about the true number does not affect their decision to implement the distribution they found fair. The results suggest that people are motivated to implement their fairness view regardless of whether their view is at odds with that of those who are affected.
The Transfer of Antarctic Circumpolar Waters to the Western South Atlantic Ocean
Authors: Olivé Abelló Anna , Pelegrí Josep L. , Machín Francisco J. , Vallès‐Casanova Ignasi
Published: June 2021

Southern Ocean waters enter the South Atlantic Ocean through the Scotia Sea along pathways constrained by the bathymetry of the northern Scotia Sea passages. We use the Argo profiling‐float data set to calculate the water transports in and out of the region, focusing on the water balances down to the deepest isoneutral sampled in all passages (γn = 28.0 kg m−3, located between about 500 and 2,000 m in the Drake Passage and even shallower in the Northern Passages). Down to this reference level, the water inflow through the Drake Passage is 140.8 ± 7.4 Sv and the water outflow through the deeper portions of the Northern Passages is 115.9 ± 8.3 Sv, implying a leakage of about 25 ± 11.1 Sv over topography shallower than 1,000 m. Below the reference isoneutral and down to 2,000 m, an additional 23.4 Sv enter through the Drake Passage; when added to reported inputs of about 20 Sv through the South Scotia Ridge, this accounts well for the observed 43.4 Sv outflow–from 28.0 kg m−3 to 2,000 m–through the Northern Passages. Relative to the 2,000 m reference level, the mean barotropic contribution always represents over half the total transports. We also observe substantial seasonal and moderate interannual variations in the water transports and composition (peak differences occur seasonally in the Drake Passage, with a range of 111–174 Sv), associated with changes in water exchange across the frontal systems. Two independent measures set the water mean‐residence time in the Scotia Sea at about 6–8 months.
Dyes and Isotopes Track Groundwater from Sink to Spring
Authors: Besl J.
Published: June 2021

The hydraulic connection between a sinkhole and a natural spring—the longest and largest yet documented—could help reduce the guesswork in mapping karst aquifers.
Estimating mouthing exposure to chemicals in children’s products
Authors: Aurisano Nicolò , Fantke Peter , Huang Lei , Jolliet Olivier
Published: June 2021

Background

Existing models for estimating children’s exposure to chemicals through mouthing currently depends on the availability of chemical- and material-specific experimental migration rates, only covering a few dozen chemicals.

Objective

This study objective is hence to develop a mouthing exposure model to predict migration into saliva, mouthing exposure, and related health risk from a wide range of chemical-material combinations in children’s products.

Methods

We collected experimental data on chemical migration from different products into saliva for multiple substance groups and materials, identifying chemical concentration and diffusion coefficient as main properties of influence. To predict migration rates into saliva, we adapted a previously developed migration model for chemicals in food packaging materials. We also developed a regression model based on identified chemical and material properties.

Results

Our migration predictions correlate well with experimental data (R2 = 0.85) and vary widely from 8 × 10−7 to 32.7 µg/10 cm2/min, with plasticizers in PVC showing the highest values. Related mouthing exposure doses vary across chemicals and materials from a median of 0.005 to 253 µg/kgBW/d. Finally, we combined exposure estimates with toxicity information to yield hazard quotients and identify chemicals of concern for average and upper bound mouthing behavior scenarios.

Significance

The proposed model can be applied for predicting migration rates for hundreds of chemical-material combinations to support high-throughput screening.
Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia
Authors: Avram Mihai , Grothe Michel J. , Meinhold Lena , Leucht Claudia , Leucht Stefan , Borgwardt Stefan , Brandl Felix , Sorg Christian
Published: June 2021

A potential pathophysiological mechanism of cognitive difficulties in schizophrenia is a dysregulated cholinergic system. Particularly, the cholinergic basal forebrain nuclei (BFCN), the source of cortical cholinergic innervation, support multiple cognitive functions, ranging from attention to decision-making. We hypothesized that BFCN structural integrity is altered in schizophrenia and associated with patients’ attentional deficits. We assessed gray matter (GM) integrity of cytoarchitectonically defined BFCN region-of-interest in 72 patients with schizophrenia and 73 healthy controls, matched for age and gender, from the COBRE open-source database, via structural magnetic resonance imaging (MRI)–based volumetry. MRI-derived measures of GM integrity (i.e., volumes) were linked with performance on a symbol coding task (SCT), a paper-pencil-based metric that assesses attention, by correlation and mediation analysis. To assess the replicability of findings, we repeated the analyses in an independent dataset comprising 26 patients with schizophrenia and 24 matched healthy controls. BFCN volumes were lower in patients (t(139)=2.51, p = 0.01) and significantly associated with impaired SCT performance (r = 0.31, p = 0.01). Furthermore, lower BFCN volumes mediated the group difference in SCT performance. When including global GM volumes, which were lower in patients, as covariates-of-no-interest, these findings disappeared, indicating that schizophrenia did not have a specific effect on BFCN relative to other regional volume changes. We replicated these findings in the independent cohort, e.g., BFCN volumes were lower in patients and mediated patients’ impaired SCT performance. Results demonstrate lower BFCN volumes in schizophrenia, which link with patients’ attentional deficits. Data suggest that a dysregulated cholinergic system might contribute to cognitive difficulties in schizophrenia via impaired BFCN.
The efficacy of anti-EGFR therapy in treating metastatic colorectal cancer differs between the middle/low rectum and the left-sided colon
Authors: Lee Kun-Han , Chen Wei-Shone , Jiang Jeng-Kai , Yang Shung-Haur , Wang Huann-Sheng , Chang Shih-Ching , Lan Yuan-Tzu , Lin Chun-Chi , Lin Hung-Hsin , Huang Sheng-Chieh , Cheng Hou-Hsuan , Chao Yee , Teng Hao-Wei
Published: June 2021

Background

Clinically, metastatic rectal cancer has been considered a subset of left-sided colon cancer. However, heterogeneity has been proposed to exist between high and middle/low rectal cancers. We aimed to examine the efficacy of anti-epidermal growth factor receptor (EGFR) treatment for middle/low rectal and left-sided colon cancers.

Methods

This study enrolled 609 patients with metastatic colorectal cancer who were treated with anti-EGFR therapy. They were divided into groups based on primary tumour locations: the right-sided colon, the left-sided colon or the middle/low rectum. The efficacy of first-line and non-first-line anti-EGFR treatment was analysed. Genomic differences in colorectal cancer data from The Cancer Genome Atlas (TCGA) were investigated and visualised with OncoPrint and a clustered heatmap.

Results

On first-line anti-EGFR treatment, patients with middle/low rectal tumours had significantly lower progression-free survival, overall survival, and overall response rates (6.8 months, 27.8 months and 43%, respectively) than those with left-sided colon cancer (10.1 months, 38.3 months and 66%, respectively). Similar outcomes were also identified on non-first-line anti-EGFR treatment. In TCGA analysis, rectal tumours displayed genetic heterogeneity and shared features with both left- and right-sided colon cancer.

Conclusions

Anti-EGFR treatment has lower efficacy in metastatic middle/low rectal cancer than in left-sided colon cancer.
Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis
Authors: Wu Hai-Yan , Zhou Yi-Min , Liao Zhu-Qin , Zhong Jia-Wen , Liu You-Bin , Zhao Hui , Liang Chi-Qian , Huang Rui-Jin , Park Kyu-Sang , Feng Shan-Shan , Zheng Li , Cai Dong-Qing , Qi Xu-Feng
Published: June 2021

Cardiovascular disease is the leading cause of death in the world due to losing regenerative capacity in the adult heart. Frogs possess remarkable capacities to regenerate multiple organs, including spinal cord, tail, and limb, but the response to heart injury and the underlying molecular mechanism remains largely unclear. Here we demonstrated that cardiomyocyte proliferation greatly contributes to heart regeneration in adult X. tropicalis upon apex resection. Using RNA-seq and qPCR, we found that the expression of Fos-like antigen 1 (Fosl1) was dramatically upregulated in early stage of heart injury. To study Fosl1 function in heart regeneration, its expression was modulated in vitro and in vivo. Overexpression of X. tropicalis Fosl1 significantly promoted the proliferation of cardiomyocyte cell line H9c2. Consistently, endogenous Fosl1 knockdown suppressed the proliferation of H9c2 cells and primary cardiomyocytes isolated from neonatal mice. Taking use of a cardiomyocyte-specific dominant-negative approach, we show that blocking Fosl1 function leads to defects in cardiomyocyte proliferation during X. tropicalis heart regeneration. We further show that knockdown of Fosl1 can suppress the capacity of heart regeneration in neonatal mice, but overexpression of Fosl1 can improve the cardiac function in adult mouse upon myocardium infarction. Co-immunoprecipitation, luciferase reporter, and ChIP analysis reveal that Fosl1 interacts with JunB and promotes the expression of Cyclin-T1 (Ccnt1) during heart regeneration. In conclusion, we demonstrated that Fosl1 plays an essential role in cardiomyocyte proliferation and heart regeneration in vertebrates, at least in part, through interaction with JunB, thereby promoting expression of cell cycle regulators including Ccnt1.
Investigating the utility of VR for spatial understanding in surgical planning: evaluation of head-mounted to desktop display
Authors: Hattab Georges , Hatzipanayioti Adamantini , Klimova Anna , Pfeiffer Micha , Klausing Peter , Breucha Michael , Bechtolsheim Felix von , Helmert Jens R. , Weitz Jürgen , Pannasch Sebastian , Speidel Stefanie
Published: June 2021

Recent technological advances have made Virtual Reality (VR) attractive in both research and real world applications such as training, rehabilitation, and gaming. Although these other fields benefited from VR technology, it remains unclear whether VR contributes to better spatial understanding and training in the context of surgical planning. In this study, we evaluated the use of VR by comparing the recall of spatial information in two learning conditions: a head-mounted display (HMD) and a desktop screen (DT). Specifically, we explored (a) a scene understanding and then (b) a direction estimation task using two 3D models (i.e., a liver and a pyramid). In the scene understanding task, participants had to navigate the rendered the 3D models by means of rotation, zoom and transparency in order to substantially identify the spatial relationships among its internal objects. In the subsequent direction estimation task, participants had to point at a previously identified target object, i.e., internal sphere, on a materialized 3D-printed version of the model using a tracked pointing tool. Results showed that the learning condition (HMD or DT) did not influence participants’ memory and confidence ratings of the models. In contrast, the model type, that is, whether the model to be recalled was a liver or a pyramid significantly affected participants’ memory about the internal structure of the model. Furthermore, localizing the internal position of the target sphere was also unaffected by participants’ previous experience of the model via HMD or DT. Overall, results provide novel insights on the use of VR in a surgical planning scenario and have paramount implications in medical learning by shedding light on the mental model we make to recall spatial structures.