bluuebunny/crossref_metadata_2025 huggingface dataset:
Ionicity and hydrogen affinity of water layers on metals
Authors: Bartelt Norman C , Thürmer Konrad
Published: October 2022

The ability of metal surfaces to dissociate hydrogen molecules is key to many ways that metals react to their environment. Often, the barrier to dissociation is linked to the formation of surface hydrogen adatoms. Here, we show that hydrogen can be more strongly bound to water-covered surfaces in the form of hydronium ions than as adatoms. Density functional theory reveals that the hydronium binding is proportional to the surface electronic work function. For the case of Pt(111), a particularly high work function surface, the proton affinity of adsorbed water films can be 0.4 eV larger than that of the bare metal surface. This binding is large enough to make the water films susceptible to the formation of hydroxyl and hydronium ion pairs. We present evidence from scanning tunneling microscopy for the existence of hydronium ions in water films on Pt(111). This new insight into the stability of hydronium-containing water layers provides a basis for more realistic models of the chemical reactivity of water films on metals.
Anticipatory countering of motor challenges by premovement activation of orexin neurons
Authors: Donegan Dane , Peleg-Raibstein Daria , Lambercy Olivier , Burdakov Denis
Published: October 2022

Countering upcoming challenges with anticipatory movements is a fundamental function of the brain, whose neural implementations remain poorly defined. Recently, premovement neural activation was found outside canonical premotor areas, in the hypothalamic hypocretin/orexin neurons (HONs). The purpose of this hypothalamic activation is unknown. By studying precisely defined mouse–robot interactions, here we show that the premovement HON activity correlates with experience-dependent emergence of anticipatory movements that counter imminent motor challenges. Through targeted, bidirectional optogenetic interference, we demonstrate that the premovement HON activation governs the anticipatory movements. These findings advance our understanding of the behavioral and cognitive impact of temporally defined HON signals and may provide important insights into healthy adaptive movements.
Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants
Authors: Nakano Masaki , Imamura Ryuki , Sugi Takuma , Nishimura Masaki
Published: October 2022

The family with sequence similarity 3 (FAM3) superfamily represents a distinct class of signaling molecules that share a characteristic structural feature. Mammalian FAM3 member C (FAM3C) is abundantly expressed in neuronal cells and released from the synaptic vesicle to the extracellular milieu in an activity-dependent manner. However, the neural function of FAM3C has yet to be fully clarified. We found that the protein sequence of human FAM3C is similar to that of the N-terminal tandem domains of Caenorhabditis elegans FAMP-1 (formerly named M70.4), which has been recognized as a tentative ortholog of mammalian FAM3 members or protein-O-mannose β-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1). Missense mutations in the N-terminal domain, named Fam3L2, caused defects in memory-based thermotaxis but not in chemotaxis behaviors; these defects could be restored by AFD neuron-specific exogenous expression of a polypeptide corresponding to the Fam3L2 domain but not that corresponding to the Fam3L1. Moreover, human FAM3C could also rescue defective thermotaxis behavior in famp-1 mutant worms. An in vitro assay revealed that the Fam3L2 and FAM3C can bind with carbohydrates, similar to the stem domain of POMGnT1. The athermotactic mutations in the Fam3L2 domain caused a partial loss-of-function of FAMP-1, whereas the C-terminal truncation mutations led to more severe neural dysfunction that reduced locomotor activity. Overall, we show that the Fam3L2 domain-dependent function of FAMP-1 in AFD neurons is required for the thermotaxis migration of C. elegans and that human FAM3C can act as a substitute for the Fam3L2 domain in thermotaxis behaviors.
Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment
Authors: Abhishek Abhishek , Fuller Amy , Nakafero Georgina , Zhang Weiya , Dumbleton Jennifer , Hawkey Christopher , Coupland Carol , Terkeltaub Robert , Doherty Michael
Published: October 2022

Objective

The aim was to test the feasibility of a randomized controlled trial exploring whether omega-3 fatty acid supplementation limits gout flares during treat-to-target urate-lowering treatment (T2T-ULT).

Methods

Adults with at least one gout flare in the past 12 months and serum urate (SU) ≥360 μmol/l were recruited from general practices (primary method) and randomly assigned 1:1 to receive omega-3 fatty acid supplementation (4 g/day) or placebo for 28 weeks. At week 5, participants began T2T-ULT. The primary outcome was drop-out rate. Secondary outcomes were recruitment rate, outcome data completeness, the number, severity and duration of gout flares between weeks 5 and 28, and study drug compliance.

Results

Ninety-five per cent of randomized participants (n = 60) completed all study visits. The primary method recruitment rate was 2.2%. Fifty and 42 participants achieved SU < 360 and 300 μmol/l (6 and 5 mg/dl), respectively. The number of gout flares [median (interquartile range): active 1 (0–2) and placebo 1 (0–2)], flare duration [mean (s.d.): active 7.00 (4.52) days and placebo 7.06 (8.14) days] and time to first flare [hazard ratio (95% CI) 0.97 (0.50, 1.86)] were comparable between both arms. Study drug compliance was high and comparable in both arms [median (interquartile range) returned capsule count: active 57 (26–100) and placebo 58 (27–154)]; red blood cell omega-3 fatty acid index increased twofold in the active arm and remained unchanged in the control arm.

Conclusion

The study demonstrated feasibility and provided useful metrics for conducting a community-based gout flare prophylaxis trial.

Study registration

ISRCTN; https://www.isrctn.com/; ISRCTN79392964.
Gender equity in rheumatology leadership in the Asia-Pacific
Authors: Khursheed Tayyeba , Ovseiko Pavel V , Harifi Ghita , Badsha Humeira , Cheng Yew Kuang , Hill Catherine L , Haq Syed Atiqul , Danda Debashish , Gupta Latika
Published: October 2022

Objectives

This study aimed to explore gender equity in rheumatology leadership in the Asia-Pacific region as represented by the member national organizations (MNOs) of the Asia-Pacific League of Associations for Rheumatology (APLAR).

Methods

We conducted a retrospective cross-sectional review of gender representation among the presidents of MNOs of APLAR in April 2022. We used the official website of each organization to acquire names and terms in the office of current and past presidents of each organization. The binary gender of each president was estimated using the name-to-gender inference platform Gender API (https://gender-api.com/). Proportions of male and female presidents were estimated for each organization. Data were compared for presidencies commencing before and in/after the year 2000.

Results

We found a significant gap in gender parity, with most presidents in the region being men (210 of 252, 83%). More than one-third (7 of 19, 36.8%) of the MNOs had all male presidents, although the proportion of women improved from 7 to 25% in/after 2000 (P = 0.0002). A statistically significant increase in female representation was observed in Australia (P = 0.0268, from 7 to 39%) and New Zealand (P = 0.0011, where the proportion of female presidents increased from 0 to 45%), but not in other countries.

Conclusion

A significant gap in gender parity exists in rheumatology leadership in the MNOs of APLAR. Trends suggest improvement over the last two decades, although statistically significant improvement is limited to a small number of countries.
Efficacy and safety of risankizumab for active psoriatic arthritis: 52-week results from the KEEPsAKE 2 study
Authors: Östör Andrew , Van den Bosch Filip , Papp Kim , Asnal Cecilia , Blanco Ricardo , Aelion Jacob , Lu Wenjing , Wang Zailong , Soliman Ahmed M , Eldred Ann , Padilla Byron , Kivitz Alan
Published: October 2022

Objective

PsA is a chronic inflammatory disease in which the skin and joints are affected. In this follow-up analysis, the 52-week efficacy and safety of risankizumab 150 mg in patients with active PsA who had previous inadequate response/intolerance to one or two biologic therapies (Bio-IR) or one or more conventional synthetic DMARDs (csDMARD-IR) were evaluated.

Methods

In the ongoing, phase 3, KEEPsAKE 2 trial, patients with active PsA were randomized 1:1 to receive subcutaneous risankizumab 150 mg or placebo at weeks 0, 4 and 16 (period 1). At week 24 (period 2), patients who received placebo were switched to risankizumab, and all patients received risankizumab 150 mg every 12 weeks from weeks 28 to 208.

Results

At week 24, 51.3% of risankizumab-treated patients (n = 224) achieved ≥20% improvement in ACR criteria (ACR 20) vs 26.5% of placebo-treated patients (n = 220; P < 0.001). At week 52, 58.5% of patients randomized to receive continuous risankizumab achieved ACR20, and 55.7% of patients who switched from placebo to risankizumab at week 24 achieved ACR20. Similar trends were observed for other efficacy measures. Rates of serious treatment-emergent adverse events (TEAEs) and TEAEs leading to discontinuation remained stable through week 52, and no deaths were reported.

Conclusion

Risankizumab was well tolerated and improved symptoms of PsA in Bio-IR/csDMARD-IR patients, with a consistent long-term safety profile from weeks 24 to 52.

Trial registration

United States National Library of Medicine clinical trials database www.clinicaltrials.gov; KEEPsAKE 2; NCT03671148.
Sustainable Finance
Authors: Edmans Alex , Kacperczyk Marcin
Published: October 2022

Sustainable finance—the integration of environmental, social, and governance (“ESG”) issues into financial decisions—is an increasingly important topic. Within companies, sustainability is no longer an ancillary issue confined to corporate social responsibility departments, but a CEO-level issue fundamental to the core business. Within the investment industry, sustainability used to be the exclusive domain of “socially responsible investors” who had social as well as financial objectives, but is now mainstream and includes investors with purely financial goals. This article introduces the RF Special Issue on Sustainability. It highlights three reasons for the rapid rise in sustainable finance—its financial relevance, its contribution to nonfinancial objectives, and investor tastes. It then summarizes the eight articles in the Special Issue, in particular drawing out their contributions to the literature. Finally, we offer ideas for future research.
Neural encoding of novel social networks: evidence that perceivers prioritize others’ centrality
Authors: Schwyck Miriam E , Du Meng , Natarajan Pratishta , Chwe John Andrew , Parkinson Carolyn
Published: October 2022

Knowledge of someone’s friendships can powerfully impact how one interacts with them. Previous research suggests that information about others’ real-world social network positions—e.g. how well-connected they are (centrality), ‘degrees of separation’ (relative social distance)—is spontaneously encoded when encountering familiar individuals. However, many types of information covary with where someone sits in a social network. For instance, strangers’ face-based trait impressions are associated with their social network centrality, and social distance and centrality are inherently intertwined with familiarity, interpersonal similarity and memories. To disentangle the encoding of the social network position from other social information, participants learned a novel social network in which the social network position was decoupled from other factors and then saw each person’s image during functional magnetic resonance imaging scanning. Using representational similarity analysis, we found that social network centrality was robustly encoded in regions associated with visual attention and mentalizing. Thus, even when considering a social network in which one is not included and where centrality is unlinked from perceptual and experience-based features to which it is inextricably tied in naturalistic contexts, the brain encodes information about others’ importance in that network, likely shaping future perceptions of and interactions with those individuals.
Estimating Global Biodiversity: The Role of Cryptic Insect Species
Authors: Li Xin , Wiens John J
Published: October 2022

How many species are there on Earth and to what groups do these species belong? These fundamental questions span systematics, ecology, and evolutionary biology. Yet, recent estimates of overall global biodiversity have ranged wildly, from the low millions to the trillions. Insects are a pivotal group for these estimates. Insects make up roughly half of currently described extant species (across all groups), with ~1 million described species. Insect diversity is also crucial because many other taxa have species that may be unique to each insect host species, including bacteria, apicomplexan protists, microsporidian fungi, nematodes, and mites. Several projections of total insect diversity (described and undescribed) have converged on ~6 million species. However, these projections have not incorporated the morphologically cryptic species revealed by molecular data. Here, we estimate the extent of cryptic insect diversity. We perform a systematic review of studies that used explicit species-delimitation methods with multilocus data. We estimate that each morphology-based insect species contains (on average) 3.1 cryptic species. We then use these estimates to project the overall number of species on Earth and their distribution among major groups. Our estimates suggest that overall global biodiversity may range from 563 million to 2.2 billion species. [Biodiversity; cryptic species; insects; species delimitation; species richness.]
Functional Characterization of Two Cell Wall Integrity Pathway Components of the MAPK Cascade inPhomopsis longicolla
Authors: Zhang Chen , Zhang Haifeng , Zheng Xiaobo , Wang Yuanchao , Ye Wenwu
Published: October 2022

The pathogenic fungus Phomopsis longicolla causes numerous plant diseases, such as Phomopsis seed decay, pod and stem blight, and stem canker, which seriously affect the yield and quality of soybean production worldwide. Because of a lack of technology for efficient manipulation of genes for functional genomics, understanding of P. longicolla pathogenesis is limited. Here, we developed an efficient polyethylene glycol–mediated protoplast transformation system in P. longicolla that we used to characterize the functions of two genes involved in the cell wall integrity (CWI) pathway of the mitogen-activated protein kinase (MAPK) cascade, including PlMkk1, which encodes MAPK kinase, and its downstream gene PlSlt2, which encodes MAPK. Both gene knockout mutants ΔPlMkk1 and ΔPlSlt2 displayed a reduced growth rate, fragile aerial hyphae, abnormal polarized growth and pigmentation, defects in sporulation, inadequate CWI, enhanced sensitivity to abiotic stress agents, and significant deficiencies in virulence, although there were some differences in degree. The results suggest that PlMkk1 and PlSlt2 are crucial for a series of growth and development processes as well as pathogenicity. The developed transformation system will be a useful tool for additional gene function research and will aid in the elucidation of the pathogenic mechanisms of P. longicolla.

[Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
A preventable, life-altering case of fluoroquinolone-associated tendonitis
Authors: Wildermuth Anne , Holmes Megan
Published: October 2022

Fluoroquinolones, such as ciprofloxacin and levofloxacin, are broad-spectrum antibacterial agents that have historically been widely used for urinary tract infections, pneumonia, and intra-abdominal infections but are associated with several serious adverse reactions, including tendinopathy and tendon rupture, peripheral neuropathy, and aortic aneurysm. These drugs should not be used for uncomplicated infections unless no other antimicrobial treatment is feasible. This article describes a patient who experienced life-altering disability from a fluoroquinolone, reviews the adverse reactions of this drug class, and discusses recommended treatment for acute uncomplicated cystitis and asymptomatic bacteriuria.
Use of Video Directly Observed Therapy and Characteristics Associated With Use Among Patients Treated With Buprenorphine in an Office-based Setting
Authors: Radick Andrea C. , James Jocelyn , Leroux Brian G. , Kim Theresa W. , Saxon Andrew J. , Samet Jeffrey H. , Tsui Judith I.
Published: October 2022

Objectives

Video directly observed therapy (video DOT) is a tool for confirming buprenorphine adherence that could complement the use of urine toxicology; research is needed to characterize the patients who are receptive and able to use this technology. We aimed to describe video DOT utilization and assess participant characteristics associated with use.

Methods

We performed a secondary analysis of data from a pilot randomized controlled trial of adults who recently initiated sublingual buprenorphine in office-based programs, restricting to intervention arm participants, which consisted of 12 weeks of video DOT via a mobile health technology platform. Participants were instructed to record at least 1 daily video of buprenorphine self-administration. Poisson regression models with robust standard errors were used to measure associations between participant characteristics and frequency of submitted videos.

Results

The sample included 39 participants. Of 3276 possible videos, 1002 (31%) were submitted. Age ≥40 years (relative risk [RR], 2.54 [95% confidence interval {CI}, 1.31–4.91]) and once-daily buprenorphine dosing (RR, 3.10 [95% CI, 1.76–5.48]) were positively associated with video submissions. Non-White race (RR, 0.43 [95% CI, 0.19–0.97]), less than high school education (RR, 0.27 [95% CI, 0.10–0.74]), history of previous buprenorphine treatment (RR, 0.50 [95% CI, 0.25–0.97]), and ≥3 previous treatment attempts (RR, 0.16 [95% CI, 0.07–0.37]) were negatively associated.

Conclusions

Video DOT utilization resulted in about a third of expected videos, although there were differences in use according to age, race, buprenorphine treatment factors, and educational status. Such differences underscore that mobile-health interventions such as video DOT may not be equally used by all patients.

Trial Registration: ClinicalTrails.gov, NCT03779997, registered on December 19, 2018.
Noninvasive Respiratory Support Does Not Prevent Extubation Failure in High-Risk Norwood Patients
Authors: Hassan Adel M. , Acosta Sebastian , Zheng Feng , Rusin Craig , Savorgnan Fabio
Published: October 2022

OBJECTIVES:

This study aims to determine whether bilevel positive airway pressure (BiPAP) and continuous positive airway pressure (CPAP) effectively mitigate the risk of extubation failure in children status post-Norwood procedure.

DESIGN:

Single-center, retrospective analysis. Extubation events were collected from January 2015 to July 2021. Extubation failure was defined as the need for reintubation within 48 hours of extubation. Demographics, clinical characteristics, and ventilatory settings were compared between successful and failed extubations.

SETTING:

Pediatric cardiovascular ICU.

PATIENTS:

Neonates following Norwood procedure.

INTERVENTIONS:

Extubation following the Norwood procedure.

MEASUREMENTS AND MAIN RESULTS:

The analysis included 311 extubations. Extubation failure occurred in 31 (10%) extubation attempts within the first 48 hours. On univariate analysis, higher rate of extubation failure was observed when patients were extubated to CPAP/BiPAP relative to patients who were extubated to either high-flow nasal cannula (HFNC) or nasal cannula (NC) (16% vs 7.8%; p = 0.027). On multivariable analysis, the presence of vocal cord anomaly (odds ratio, 3.08; p = 0.005) and lower pre-extubation end-tidal co
2 (odds ratio, 0.91; p = 0.006) were simultaneously associated with extubation failure while also controlling for the post-extubation respiratory support (CPAP/BiPAP/HFNC vs NC).

CONCLUSIONS:

Clinicians should not rely on CPAP or BiPAP as the only supportive measure for a patient at increased risk of extubation failure. CPAP or BiPAP do not mitigate the risk of extubation failure in the Norwood patients. A multisite study is needed to generalize these conclusions.
Nehemiah Grew, the illustrator
Authors: Mackenzie Pamela
Published: October 2022

The literature on seventeenth-century Royal Society member Nehemiah Grew's artistic production has been sparse and tentative. Although his publication record includes five illustrated books, some of which feature quite elaborate illustrative programmes, it has been challenging to credit any of this visual production directly to the books’ author. In this article, I aim to both contribute to the growing interest in Grew's illustrations, and to provide a corrective to this gap in the literature, presenting Grew for the first time as an active illustrator and arguing for the importance of Grew's visual production during his career with the Royal Society. I will discuss his visual archive and his relationship with his engravers and will also present evidence of his regular use of illustrated figures in lectures he presented throughout the 1670s. This includes attributing two original drawings to Grew that are still present in the Royal Society's collections—two dissected cat's kidneys—that are associated with a lecture he gave on animal anatomy in 1679.
Chelonus inanitus bracovirus encodes lineage-specific proteins and truncated immune IκB-like factors
Authors: Cerqueira de Araujo Alexandra , Josse Thibaut , Sibut Vonick , Urabe Mariko , Asadullah Azam , Barbe Valérie , Nakai Madoka , Huguet Elisabeth , Periquet Georges , Drezen Jean-Michel
Published: October 2022

Bracoviruses and ichnoviruses are endogenous viruses of parasitic wasps that produce particles containing virulence genes expressed in host tissues and necessary for parasitism success. In the case of bracoviruses the particles are produced by conserved genes of nudiviral origin integrated permanently in the wasp genome, whereas the virulence genes can strikingly differ depending on the wasp lineage. To date most data obtained on bracoviruses concerned species from the braconid subfamily of Microgastrinae. To gain a broader view on the diversity of virulence genes we sequenced the genome packaged in the particles of Chelonus inanitus bracovirus (CiBV) produced by a wasp belonging to a different subfamily: the Cheloninae. These are egg-larval parasitoids, which means that they oviposit into the host egg and the wasp larvae then develop within the larval stages of the host. We found that most of CiBV virulence genes belong to families that are specific to Cheloninae. As other bracoviruses and ichnoviruses however, CiBV encode v-ank genes encoding truncated versions of the immune cactus/IκB factor, which suggests these proteins might play a key role in host–parasite interactions involving domesticated endogenous viruses. We found that the structures of CiBV V-ANKs are different from those previously reported. Phylogenetic analysis supports the hypothesis that they may originate from a cactus/IκB immune gene from the wasp genome acquired by the bracovirus. However, their evolutionary history is different from that shared by other V-ANKs, whose common origin probably reflects horizontal gene transfer events of virus sequences between braconid and ichneumonid wasps.
Performance Evaluation of Prediction on Molecular Graphs with Graph Neural Networks
Authors: Li Haotian
Published: October 2022

Abstract

Machine learning and deep learning are novel and trending approaches to solving real-world scientific problems. Graph machine learning is dedicated to performing learning methods, such as graph neural networks, on non-Euclidean data such as graphs. Molecules, with their natural graph structures, could be analyzed by such method. In this work, we carry out the performance evaluation regarding to learning results as well as time consumed, speedup, and efficiency using different types of neural network structures and distributed training pipeline implementations. Besides, the reasons lead to an unideal performance enhancement is investigated. Code availability athttps://github.com/htlee6/perf-analysis-dist-training-gnn.
Progressive alignment of crystals: reproducible and efficient assessment of crystal structure similarity
Authors: Nessler Aaron J. , Okada Okimasa , Hermon Mitchell J. , Nagata Hiroomi , Schnieders Michael J.
Published: October 2022

Duringin silicocrystal structure prediction of organic molecules, millions of candidate structures are often generated. These candidates must be compared to remove duplicates prior to further analysis (e.g.optimization with electronic structure methods) and ultimately compared with structures determined experimentally. The agreement of predicted and experimental structures forms the basis of evaluating the results from the Cambridge Crystallographic Data Centre (CCDC) blind assessment of crystal structure prediction, which further motivates the pursuit of rigorous alignments. Evaluating crystal structure packings using coordinate root-mean-square deviation (RMSD) forNmolecules (orNasymmetric units) in a reproducible manner requires metrics to describe the shape of the compared molecular clusters to account for alternative approaches used to prioritize selection of molecules. Described here is a flexible algorithm calledProgressive Alignment of Crystals(PAC) to evaluate crystal packing similarity using coordinate RMSD and introducing the radius of gyration (Rg) as a metric to quantify the shape of the superimposed clusters. It is shown that the absence of metrics to describe cluster shape adds ambiguity to the results of the CCDC blind assessments because it is not possible to determine whether the superposition algorithm has prioritized tightly packed molecular clusters (i.e.to minimizeRg) or prioritized reduced RMSD (i.e.via possibly elongated clusters with relatively largerRg). For example, it is shown that when thePACalgorithm described here uses single linkage to prioritize molecules for inclusion in the superimposed clusters, the results are nearly identical to those calculated by the widely used programCOMPACK. However, the lowerRgvalues obtained by the use of average linkage are favored for molecule prioritization because the resulting RMSDs more equally reflect the importance of packing along each dimension. It is shown that thePACalgorithm is faster thanCOMPACKwhen using a single process and its utility for biomolecular crystals is demonstrated. Finally, parallel scaling up to 64 processes in the open-source codeForce Field Xis presented.
Automatic bad-pixel mask maker for X-ray pixel detectors with application to serial crystallography
Authors: Sadri Alireza , Hadian-Jazi Marjan , Yefanov Oleksandr , Galchenkova Marina , Kirkwood Henry , Mills Grant , Sikorski Marcin , Letrun Romain , de Wijn Raphael , Vakili Mohammad , Oberthuer Dominik , Komadina Dana , Brehm Wolfgang , Mancuso Adrian P. , Carnis Jerome , Gelisio Luca , Chapman Henry N.
Published: October 2022

X-ray crystallography has witnessed a massive development over the past decade, driven by large increases in the intensity and brightness of X-ray sources and enabled by employing high-frame-rate X-ray detectors. The analysis of large data sets is done via automatic algorithms that are vulnerable to imperfections in the detector and noise inherent with the detection process. By improving the model of the behaviour of the detector, data can be analysed more reliably and data storage costs can be significantly reduced. One major requirement is a software mask that identifies defective pixels in diffraction frames. This paper introduces a methodology and program based upon concepts of machine learning, called robust mask maker (RMM), for the generation of bad-pixel masks for large-area X-ray pixel detectors based on modern robust statistics. It is proposed to discriminate normally behaving pixels from abnormal pixels by analysing routine measurements made with and without X-ray illumination. Analysis software typically uses a Bragg peak finder to detect Bragg peaks and an indexing method to detect crystal lattices among those peaks. Without proper masking of the bad pixels, peak finding methods often confuse the abnormal values of bad pixels in a pattern with true Bragg peaks and flag such patterns as useful regardless, leading to storage of enormous uninformative data sets. Also, it is computationally very expensive for indexing methods to search for crystal lattices among false peaks and the solution may be biased. This paper shows how RMM vastly improves peak finders and prevents them from labelling bad pixels as Bragg peaks, by demonstrating its effectiveness on several serial crystallography data sets.
Identification of critical success factors for leveraging Industry 4.0 technology and research agenda: a systematic literature review using PRISMA protocol
Authors: Sahoo Poonam , Saraf Pavan Kumar , Uchil Rashmi
Published: October 2022

Purpose

The purpose of the paper is to identify existing and common critical success factors adapted for implementing Industry 4.0 technology, which is essential to survive in the vulnerability, uncertainty, complexity and ambiguity (VUCA) environment by using systematic literature review (SLR) methodology with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and content analysis strategy.

Design/methodology/approach

The SLR methodology with the PRISMA and content analysis strategy adapted to review 74 papers in peer-reviewed academic journals and industry reports published from 2014 to 2021.

Findings

Based on a review of relevant literature, two theoretical contributions have been added to the literature on Industry 4.0. First, this review reveals that 35 (47%) out of total 74 studies assessing the Industry 4.0 implementation in the manufacturing industry, the service industry can also create value through Industry 4.0 implementation, with a lot of potential to increase productivity, which literature has not explicitly focused on. Second, this paper proposes the 12 most common critical factors (training and development, organizational culture, top management support, organizational structure, innovation capability, technological infrastructure, security system, standardization of procedures, financial resources, communication and cooperation, change management and governance) that can be considered as the significant critical factors for successful implementation of Industry 4.0.

Originality/value

The novelty part related to methodological perspective by using the PRISMA approach for systematic review, which cannot be found extensively in existing literature in the context of the Industry 4.0 phenomenon to analyze critical factors.
Buildability attributes for improving the practice of construction management in Nigeria
Authors: Osuizugbo Innocent Chigozie , Oshodi Olalekan Shamsideen
Published: October 2022

Purpose

The awareness and practice of buildability is still at its infancy stage in the construction sector of developing countries. Information gleaned from literature shows that embedding buildability into practice is beneficial to construction projects. This study seeks to examine the buildability attributes that are important for improving the practice of construction management.

Design/methodology/approach

A questionnaire was developed to address the aim of the study. Data were collected through the administration of questionnaires to purposively selected group of architects, engineers, builders and quantity surveyors. A total of 368 questionnaires were administered and a response rate of 60% (219 questionnaires were returned) was achieved. Descriptive and inferential statistics were used in analysing the data.

Findings

The results revealed that discussion centred on buildable designs among builders and designers as the most critical attribute of buildability for improving the practice of construction management in the Nigerian construction industry. The finding also revealed that, there is a statistically significant agreement between different groups of construction organisations in Lagos state, Nigeria concerning buildability attributes for improving the practice of construction management.

Originality/value

This study highlights the buildability attributes which are important for improving the practice of construction management. An understanding of these attributes is essential for improving and embedding buildability as a practice in the construction industry.
Excessive use of social networking sites and financial well-being among working millennials: a parallel-serial mediation model
Authors: She Long , Ma Lan , Voon Mung Ling , Lim Agnes Siang Siew
Published: October 2022

Purpose

This study aimed to investigate the mediating role of financial attitude and perceived behavioral control with financial behavior in the association between excessive use of social networking sites (SNSs) and financial well-being among working millennials.

Design/methodology/approach

A crossed-sectional survey was used to obtain data through a self-administered questionnaire. A total of 485 working millennials (M age = 32.28, years, SD age = 4.75) in Malaysia participated in the study based on a purposive sampling technique. Covariance-based structural equation modeling (CB-SEM) was used to evaluate the measurement model and the proposed serial mediation model.

Findings

The findings of this study revealed that excessive use of SNS is negatively associated with financial well-being. Also, the findings suggested that financial attitude and perceived behavioral with financial behavior serially mediated the negative relationship between excessive use of SNS and financial well-being, respectively.

Practical implications

Several implications were suggested and discussed to prevent the negative impact of excessive SNS use on financial well-being among young working adults. Policymakers and financial service providers (e.g. banks) can draw from the findings by constantly framing and delivering their messages to increase the young working adults' awareness of pitfalls of excessive use of innovative technologies on their financial attitudes and self-control over their behaviors and financial well-being.

Originality/value

This study entails some new insights on examining the impact of excessive use of SNS on working millennials' financial well-being as well as the underlying mechanisms behind this phenomenon.
Investigating social risks of construction projects in historic tourism sites in urban districts of developing countries: social network analysis approach
Authors: Jokar Saba , Shojaei Payam , Askarifar Kazem , Haqbin Arash
Published: October 2022

Purpose

Social risk management has recently come to the fore as a significant feature of project management. This prominence is particularly evident in urban construction projects that take place in cultural heritage and tourism historic sites. Accordingly, this study aims to adopt social network analysis (SNA) to investigate social risks in construction projects occurring in urban districts rife with historically and culturally significant tourism sites.

Design/methodology/approach

The present study analyzed a real case study in Iran as an emergent economy and a developing country. Primarily, the study reviewed previous literature on social risks and relevant stakeholders. Next, the judgments of experts through the content validity ratio analysis confirmed 12 social risks and 9 key stakeholders. Finally, SNA is used to determine the relations between the social risks and stakeholders as well as the significance of each risk.

Findings

The investigation demonstrated that the most important social risks in the construction projects of the case study are “Psychological disorders”, “Environmental pollution” and “Cultural conflicts”.

Practical implications

The findings could help policymakers, urban planners and project managers in developing countries with a rich cultural heritage to reduce social risks and improve the efficiency of their projects.

Originality/value

To the best of the authors’ knowledge, the present study is one of the first instances to investigate construction projects implemented in densely populated urban areas hosting cultural heritage and historic tourism sites.
Artist residencies as specialist accommodation: cultural entrepreneurship during the COVID-19 pandemic
Authors: Andriotis Konstantinos , Paraskevaidis Pavlos
Published: October 2022

Purpose

Artist residencies comprise a unique accommodation type and a form of cultural entrepreneurship which remains overlooked from a hospitality perspective. This exploratory study aims to examine the phenomenon of artist residencies as specialist accommodation, as well as their operators’ motives as cultural entrepreneurs during the COVID-19 pandemic. Creation theory is used to explore how artist residency operators create entrepreneurial opportunities.

Design/methodology/approach

Asynchronous email interviews were conducted with 20 artist residency operators from 18 countries. Purposive sampling was used to select interviewees and thematic analysis to analyze the primary data.

Findings

The results showed that with few exceptions, artist residencies address all criteria of specialist accommodation, and that social interactions among artists and operators are fundamental in running an artist residency. From a cultural entrepreneurship perspective, most of the operators declared that their priorities were to promote artistic creativity and cultural knowledge exchange, confirming the main elements of creation theory.

Practical implications

Managerial implications are discussed to enhance the resilience of artist residencies and strengthen their financial viability, as well as to support them to overcome the devastating impacts of the COVID-19 pandemic.

Originality/value

This study extends the hospitality literature by adding the artist residencies to the existing types of specialist accommodation. It also examines creation theory and concludes that artistic creativity and cultural networks are prominent in artist residency entrepreneurial activities.
Does perceived overqualification lead employees to further knowledge hiding? The role of relative deprivation and ego depletion
Authors: Yeşiltaş Murat , Arici Hasan Evrim , Sormaz Ümit
Published: October 2022

Purpose

This study aims to examine how perceived overqualification (POQ) influences employee knowledge hiding (KH) behaviors. This study further investigates the mediating effect of relative deprivation (RD) and the moderating effect of ego depletion (ED), jointly leading to moderated-mediation analysis.

Design/methodology/approach

Having used a time lag, a total of 850 hotel employees participated in Time 1, and data was gathered from 732 hotel employees in Time 2. Using PROCESS macro, a moderated-mediation analysis was performed to examine the hypothesized relationships.

Findings

This study’s findings display that POQ has a positive impact on KH. Moreover, RD plays a mediating role and ED has a moderating role in the direct and indirect associations between POQ and KH.

Practical implications

The findings suggest that hospitality and tourism (H&T) practitioners need to structure job positions, particularly job descriptions and specifications, by considering employee qualifications. They could encourage qualified employees to participate in the decision-making process which can increase the likelihood of their knowledge sharing and naturally limit KH behaviors.

Originality/value

In addition to adding to the burgeoning literature on POQ in the H&T sector, this study advances research on the RD and ED theories by statistically analyzing the link between POQ and employee KH. By considering RD as a mediator, a better comprehension is provided concerning “how” POQ associates with employee KH. By introducing ED as a moderator, researchers could better understand “when” POQ significantly associates with employee KH.
A bibliometric review of research on interorganizational conflicts in the construction industry: 1989-2021
Authors: Wu Guangdong , Zhu Yan , Hu Zhibin
Published: October 2022

Purpose

The issue of conflict has been around for a long time. With the development of economic development and the diversification of industries, conflicts have shown a trend of complex development. By reviewing interorganizational conflict in construction, this study aims to identify the formation, development and evolution of conflict and to assist organizational managers in using scientific conflict management tools to deal with and resolve conflict.

Design/methodology/approach

This paper considers the following questions: “What is the overall research status of the interorganizational conflict in construction projects?” and “What are the trendy issues in interorganizational conflicts in construction projects?” This study uses R software's Biblioshiny program to describe the overall conflict between organizations to answer question 1. This study uses Netminer – a social network analysis (SNA) software and text mining to explore research trends and answer question 2.

Findings

Interorganizational conflict has been one of the most important topics in recent years when it comes to conflict issues. This paper intends to examine interorganizational conflict in construction in an attempt to shed light on four main topics regarding the conflict: the application of conflict theory; factors that induce conflict; the effect of conflict on performance; and methods of conflict management.

Research limitations/implications

Through a comprehensive analysis of interorganizational conflict, this study helps to increase the understanding of scholars in the field of conflict research. This study suggests future research directions and provides references for managers to improve their conflict management, decision-making and performance.

Originality/value

This study combines bibliometrics, SNA and text mining research methods. Multidimensional and multiperspectival assessments are performed based on the status of the research, its evolution and trends. The results of this study can be used to guide the resolution of conflict in other industries. This study also enriches the scientific theory related to the interorganizational conflict.
Intersectionality in HR research: challenges and opportunities
Authors: Gunderson Morley
Published: October 2022

Purpose

The purpose of this paper is to review the literature on intersectionality and ascertain its potential for application to human resources (HR) research and practice. Particular attention is paid to its methodological issues involving how best to incorporate intersectionality into research designs, and its data issues involving the “curse of dimensionality” where there are too few observations in most datasets to deal with multiple intersecting categories.

Design/methodology/approach

The methodology involves reviewing the literature on intersectionality in its various dimensions: its conceptual underpinnings and meanings; its evolution as a concept; its application in various areas; its relationship to gender-based analysis plus (GBA+); its methodological issues and data requirements; its relationship to theory and qualitative as well as quantitative lines of research; and its potential applicability to research and practice in HR.

Findings

Intersectionality deals with how interdependent categories such as race, gender and disability intersect to affect outcomes. It is not how each of these factors has an independent or additive effect; rather, it is how they combine together in an interlocking fashion to have an interactive effect that is different from the sum of their individual effects. This gives rise to methodological and data complications that are outlined. Ways in which these complications have been dealt with in the literature are outlined, including interaction effects, separate equations for key groups, reducing data requirements, qualitative analysis and machine learning with Big Data.

Research limitations/implications

Intersectionality has not been dealt with in HR research or practice. In other fields, it tends to be dealt with only in a conceptual/theoretical fashion or qualitatively, likely reflecting the difficulties of applying it to quantitative research.

Practical implications

The wide gap between the theoretical concept of intersectionality and its practical application for purposes of prediction as well as causal analysis is outlined. Trade-offs are invariably involved in applying intersectionality to HR issues. Practical steps for dealing with those trade-offs in the quantitative analyses of HR issues are outlined.

Social implications

Intersectionality draws attention to the intersecting nature of multiple disadvantages or vulnerability. It highlights how they interact in a multiplicative and not simply additive fashion to affect various outcomes of individual and social importance.

Originality/value

To the best of the author’s knowledge, this is the first analysis of the potential applicability of the concept of intersectionality to research and practice in HR. It has obvious relevance for ascertaining intersectional categories as predictors and causal determinants of important outcomes in HR, especially given the growing availability of large personnel and digital datasets.
A human augmentation device design review: supernumerary robotic limbs
Authors: Liao Ziyu , Chen Bai , Chang Tianzuo , Zheng Qian , Liu Keming , Lv Junnan
Published: October 2022

Purpose

Supernumerary robotic limbs (SRLs) are a new type of wearable robot, which improve the user’s operating and perceive the user’s environment by extra robotic limbs. There are some literature reviews about the SRLs’ key technology and development trend, but the design of SRLs has not been fully discussed and summarized. This paper aims to focus on the design of SRLs and provides a comprehensive review of the ontological structure design of SRLs.

Design/methodology/approach

In this paper, the related literature of SRLs is summarized and analyzed by VOSviewer. The structural features of different types of SRLs are extracted, and then discuss the design approach and characteristics of SRLs which are different from typical wearable robots.

Findings

The design concept of SRLs is different from the conventional wearable robots. SRLs have various reconfiguration and installed positions, and it will influence the safety and cooperativeness performance of SRLs.

Originality/value

This paper focuses on discussing the structural design of SRLs by literature review, and this review will help researchers understand the structural features of SRLs and key points of the ontological design of SRLs, which can be used as a reference for designing SRLs.