bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing the Meaning of Life Model: Introduction of the Main Components of the Model Structure
Authors: Dombrovskis Valerījs , Ignatjeva Svetlana , Berga Luīze
Published: January 2023

The debate about the meaning of life in the literature has been around for a while and portraits a fundamental human need to find a personal path of existence. The meaning of life phenomenon purpose lies in its impact on the psychological wellbeing. Knowing your purpose in life can make it more structured and in balance, therefore more meaningful and comprehensible. However, in the existing body of the academic literature meaning of life is discussed more from the philosophic perspective rather than a practical area, which is not helping to solve the global issues of increasing mental health problems. When social and emotional wellbeing is being affected, it is urgent to apply a practical approach to effectively overcome these states. Introduction of a new, holistic meaning of life model is an attempt to offer a practical solution for society to maintain their mental health through awareness of their life’s purpose. Previously in the pilot study (Dombrovskis, 2017) in a sample group of 100 citizens of Latvia who self-reported being in a crisis situation at the given moment, using qualitive analysis the first component for the model structure was identified – antecedent. In our research antecedent is defined as something that triggers certain action, so in crisis situation person can regain a structure and stability in life. We found 8 different antecedents that trigger behavior of those affected by crisis: achievements; power; success; development; freedom; uniqueness; interesting life and fleeing. To continue to explore other components for our model in the setting of Latvia, this study aims to investigate the demographic and personality related variables that may serve as antecedents and as such become one of component in our model structure. The study used a sample of residents of Latvia representing the total population of 1,110 respondents (633 women, 57%, and 477 men, 43%) who have completed the self-assessment questionnaire Meaning of life scale (MOLS) (online and frontally) designed by the authors on their satisfaction with different factors regarding the meaning of life. Average age of respondents (M=33.88; SD=8,527) varied from 18 to 67. The exploratory and confirmatory analysis confirms the data regarding existence of totally 16 factors: 8 antecedents identified in the pilot study and 8 new antecedents identified in the present study - family relations; level of income; relations with friends/acquaintances; state of health; organization of free time; career growth (achievements); sexual life quality and quality of education. Findings confirm a model’s structure to be complex phenomenon consisting of various components. However, findings suggest that more research should be done to fill the following gaps: 1) identify actions, which are triggered by 16 antecedents; 2) figure out F1, F2 and F3 factor role in the model structure.
La Educación Física en el nivel inicial desde un enfoque sociocultural
Authors: Dupuy Manuel , Gómez Smyth Leonardo
Published: January 2023

La presente investigación tiene como objetivo caracterizar las prácticas pedagógicas progresivas en educación física en el nivel inicial, buscando describir, la voz de los docentes: la función social que se le asigna al área, el conocimiento de la cultura corporal, la concepción del juego y la modalidades de planificación que proponen. El diseño metodológico es descriptivo (Samaja, 1994), síncrono/transaccional (Hernández Sampieri, Fernández Collado y Batista Lucio, 2006), con un muestreo probabilístico, de tipo aleatorio simple (Ynoub, 2015) en el que el momento es de 50 docentes. que actualmente se encuentran trabajando en el sistema educativo (nivel inicial) han sido entrevistados. Las prácticas pedagógicas progresivas (entre innovación y transformación) en la Educación Física del Nivel Inicial sustentan que el área curricular promueva el derecho al juego y la construcción de la identidad corporal de los niños y niñas como ejes permanentes de experiencia en los encuentros, estableciendo mismo como conocimiento. asociado a la cultura corporal. Las modalidades de planificación son abiertas, flexibles, teniendo presente la palabra de lxs niños y articulando con la acción de evaluación formativa; Para ellos utilizan como formatos el cuaderno de planificación bitácora/caducado y el proyecto de educación física.
Digitalisasi UMKM sebagai Upaya Peningkatan Pemasaran dan Penjualan Online di Desa Tengklik
Authors: Irianto Heru , Viesta Arey Dela , Nugroho Adam Tri , Wahyuni Tri , Prabowo Widhi Cahyo , Hamid Indra Nur , Anufah Tiyas Nur , Permatasari Harum Indah , Salsabila Azkia , Sofyana Sofyana , Hardiyanti Feni Yunita
Published: January 2023

Digitizing MSMEs is one of the problems for MSMEs in Indonesia, including MSMEs in Tengklik Village, Tawangmangu, Karanganyar, Central Java. This activity was carried out by the UNS KKN 146 group to introduce the digitization of MSMEs for marketing and increasing online sales. This activity was conducted using the case study method in order to obtain appropriate and valid data. Collecting data in this study using interview and observation techniques. The population used in this study was all the people of Tengklik Village who participated in the training activities and this population was the sample for this study. The village community was very enthusiastic about taking part in the training and gaining new knowledge. The digitalization of MSMEs is able to increase the marketing of MSME production and increase online sales of MSME production. The results obtained from the socialization are increasing MSME actors' knowledge regarding online marketing or digital marketing. In addition, every MSME actor who participates in the socialization can also create a brand for their product and is also able to identify consumer or market needs, select consumer or market targets, identify competitors, means to compete, use electronic media for marketing.
Identifikasi faktor penyediaan air bersih perpipaan (studi kasus: Kota Surakarta)
Authors: Ramadanti Lutvi , Yudhana Galing , Rini Erma Fitria
Published: January 2023

Air bersih merupakan hak dan kebutuhan dasar manusia yang penyediaannya menjadi tanggung jawab pemerintah. Kota Surakarta sebagai kota utama di Provinsi Jawa Tengah masih memiliki permasalahan dalam penyediaan air bersih perpipaan yang disediakan oleh pemerintah kota. Permasalahan tersebut antara lain belum optimalnya sistem penyediaan air regional dan belum terpenuhinya penyediaan air bersih yang terlindungi bagi seluruh warga kota. Kondisi tersebut menunjukkan kegagalan pemenuhan target 95% penduduk mengakses air bersih terlindungi pada tahun 2020. Untuk mencapai target tersebut, perlu adanya identifikasi faktor-faktor apa saja yang mempengaruhi penyediaan air bersih perpipaan Kota Surakarta sehingga dapat menjadi bahan pemecahan masalah dalam menentukan strategi yang tepat. Penelitian ini menggunakan teknik analisis Delphi dan analisis deskriptif. Berdasarkan hasil analisis, faktor-faktor yang mempengaruhi penyediaan air bersih perpipaan Kota Surakarta terbagi atas tiga kelompok faktor. Faktor primer yang memiliki pengaruh besar dalam penyediaan air bersih perpipaan Kota Surakarta yang terdiri atas variabel pencemaran sumber air, kuantitas air, kontinuitas air, dan tingkat kehilangan air. Lalu, terdapat faktor sekunder sebagai pendukung faktor primer terdiri atas kelembagaan, tarif dasar air, pembiayaan operasional, dan teknologi. Terakhir, faktor tersier berupa pelayanan penyedia air bersih.
Studi penurunan kapasitas jalan akibat dari hambatan samping guna lahan pendidikan (studi kasus Jalan Menteri Supeno dan Jalan MT Haryono, Surakarta)
Authors: Rahman Haidi Fathur , Putri Rufia Andisetyana , Suminar Lintang
Published: January 2023

Penggunaan lahan pendidikan pada suatu ruas jalan dapat menyebabkan hambatan samping yang berpengaruh terhadap penurunan kapasitas jalan tersebut, salah satunya yaitu yang terjadi pada kawasan pendidikan Manahan, Kota Surakarta. Namun, pandemi Covid-19 pada tahun 2020 mewajibkan sekolah untuk melakukan pembelajaran jarak jauh atau dari rumah. Penelitian ini bertujuan untuk mengetahui pengaruh hambatan samping guna lahan pendidikan di Jalan Menteri Supeno dan Jalan M.T. Haryono, Surakarta dengan cara membandingkan antara kondisi sebelum pandemi Covid-19 dengan saat Covid-19 terjadi. Penelitian ini menggunakan pendekatan deduktif dengan data kuesioner melalui google form dan data dokumen pemerintah. Analisis deskriptif yang dilakukan menunjukkan ada empat jenis hambatan samping guna lahan pendidikan yang dapat mempengaruhi kapasitas jalan, yaitu pejalan kaki yang keluar masuk guna lahan pendidikan, kendaraan lambat yang keluar masuk guna lahan pendidikan, kendaraan keluar masuk guna lahan pendidikan, dan kendaraan parkir atau berhenti di depan guna lahan pendidikan. Berdasarkan hasil analisis, hambatan samping guna lahan pendidikan di Jalan Menteri Supeno dan Jalan M.T. Haryono, Surakarta mempunyai pengaruh terhadap penurunan kapasitas jalan pada setiap ruas jalannya.
Current Situation of the Business Continuity Plan Preparation in Japan: Community General Support Centers
Authors: Iguchi Aya , Ishida Chie , Sato Taichi , Okada Risa , Kanesaka Takayuki , Kanno Taro
Published: January 2023

Objective: This study aims to clarify the actual situation of the business continuity plan (BCP) preparation in the community general support centers in Japan. Method: In September 2021, a survey was administered to 5,391 community general support centers all over Japan using a self-input Web questionnaire. Results: 577 responses were obtained, for a response rate of 10.7%, among which “BCP has been created” accounts for 9.5%; “BCP has not been created, and there is no plan to create any,” 22.0%; “it is currently being examined whether to create BCP,” 47.0%; and “BCP is now being created,” 21.5%. The community general support centers that “have not determined the division of roles” with their municipalities in responding to disaster account for 64%. Conclusions: This study clarifies the situation of the community general support centers in Japan, based on which they cannot be said to be prepared for a disaster. From the word network of answers to our questionnaire, we can see reasons why the BCP has not been created: lack of knowledge and busy work. Centers that have not prepared a BCP, understand the need to create one, but they are too busy and are unaware of how to do so. We discuss measures to promote the creation of BCPs by community general support centers in the future, given the current situation.
Infection from an Iliosacral Screw 16 Years Postoperatively in Demolition Derby Umpire Crushed Between 2 Cars
Authors: Brahme Indraneel S. , Hu Caroline H. , Cole Peter A.
Published: January 2023

Case:

A 47-year-old man crushed between 2 cars during a demolition derby, a nonracing North American motorsport, underwent open reduction and internal fixation, iliosacral screw fixation, arterial embolization, and multiple urologic procedures after massive pelvic ring injury, remarkably recovering nearly full function. Sixteen years after injury, he developed an abscess emanating from an iliosacral screw requiring irrigation, debridement, and hardware removal.

Conclusion:

Deep surgical infections from iliosacral screws may present late, even more than 15 years after the original surgery. Obesity, preoperative embolization, diabetes, and urethral injuries are relevant risk factors. Similar patients should have a low threshold for infection workup when presenting with symptoms, even years after surgery.
Learning Model For Special Needs Children (ABK) in Inclusive Primary Schools
Authors: Rahmawati Indriana , Basith Abdul , Toba Rostanti
Published: January 2023

The learning process of students with special needs requires a model that adapts to the specificity of students. Therefore, the learning of students with special needs must be formulated by choosing the right model, so that the delivery of subject matter is well understood. So that education for students with special needs is met the same as students in general. This research was conducted to determine the learning model of students with special needs inclusive elementary schools in Gresik district, namely SDN 263 Gresik and SDN 13 Gresik. Data collection was carried out using interviews, observation, and documentation. There are seven primary data sources, including the head of the Gresik district resource center, the principal, the teacher in charge of the inclusion program, and the special companion teacher (GPK). The research was conducted for nine months, from July 2019 to April 2020. Qualitative was chosen as the research analyzer. The results of the study found that the use of the ABK learning model in the two schools is; a) Individual learning model, b) Pull out learning model or learning model in regular classes, c) Team teaching-learning model, d) Learning Model in the resource room, e) Modification of the learning curriculum.
Can Islamic Stories be Used as Supplementary English Materials at Islamic Elementary Schools?
Authors: Maesaroh Dwi Titi , Aridah Aridah , Rusmawaty Desy
Published: January 2023

Along with the Islamic schools’ vision and mission, their curriculum generally integrates Islamic values with all subjects taught at schools including the English subject. However, the implementation of the integration is still considered a challenge. This research aimed at confirming the possibility of Islamic stories being used as supplementary materials for English teaching at Islamic elementary schools and give an analysis of how to develop Islamic stories for English teaching materials. This research was carried out at SD IT Insan Karim, Samarinda. Employing a qualitative design, this research used interviews, observation, and documentation to collect data. The interviews with the school principal, English teacher, and one of the parents were carried out to obtain data regarding the curriculum and policies, the target needs, and the learning needs of the English subject. Observation and documentation were managed to support and confirm the findings. Data collected was then analyzed through data condensation, data display, and conclusion drawing/verification. The results show that Islamic stories can be used as supplementary materials to integrate English teaching and Islamic values in the context of Islamic elementary schools. Islamic stories should be developed by considering several aspects and steps such as the curriculum, the language used, illustration and appearance, guidance for teachers, and moral lessons/values. The result of this research could serve as the basis for designing Islamic stories as supplementary materials and have implications for further research and development particularly in the context of Islamic elementary schools.
Grateful Personality Development of Junior High School Students in East Kalimantan
Authors: Afandi Nur Kholik , Pranajaya Syatria Adymas
Published: January 2023

A grateful personality is one of the essential elements in the personality development of students. This personality is reflected in verbal and deeds as a manifestation of acknowledgment in the heart for the blessings. This personality encourages students to appreciate and repay the kindness of others. This study aims to determine the level of gratitude of junior high school students in East Kalimantan. This study used a mixed-method approach. Respondents in this study were 714 people. The mean test results showed that the level of students' gratitude at Junior High Schools in East Kalimantan was very high, with an average score of 4.6. The teacher's strategies in instilling a grateful personality are with advice, exemplary, assignments, habituation, and activity programs at school. The methods are by providing materials (lectures, advice, discussions, and questions and answers related to gratitude), exemplary by providing examples of the values of gratitude, giving demonstration tasks, and practice in gratitude, giving the task of making a list of good things that have been felt and should be grateful for every day, habituation to good things (instilling the nature of qana'ah, giving appreciation and motivation, presenting a sense of empathy around oneself, inviting self-introspection, giving charity, helping others, spreading smiles, greetings, visiting friends or teachers who are sick or grieving), and school programs (dhuha and dzuhur prayers in congregation, reading the Qur'an, praying before starting lessons, and giving sadaqah every Friday at school). The results of this study may have an implication to become a policy regulation for schools to support the development of a grateful personality for students of Junior High School.
The Ability of Early Childhood Education Teachers in Counseling Communication in East Kalimantan
Authors: Robingatin Robingatin , Malik Lina Revilla , Komariah Anis
Published: January 2023

The background of this research is that Early Childhood Education teachers play an important role in interactions both as teachers in learning and as mentors and counselors for children. PAUD (Early Childhood Education) teachers are expected to have counseling communication skills, including empathy, active listening, and the ability to ask questions. This research aimed to find out the ability of Early Childhood Education Teachers in East Kalimantan in counseling communication. The research design was descriptive qualitative. The subjects in this study were Early Childhood Education Teachers from 8 PAUD institutions in 4 (four) City Districts in the East Kalimantan regions. There are Samarinda, Bontang, Kutai Kartanegara, and Kutai Timur. This subject was taken purposively from two teachers selected in each institution that was used as a place of research. The research object was the teacher's ability to conduct counseling communication by attending, empathizing, asking questions, and active listening skills. From this study, the researcher concluded that most Early Childhood Education Teachers can empathize but have not implemented empathic communication and effective listening in asking questions to explore children's emotions and thoughts. Most teachers used advising, seducing, persuading, and diverting children's problems in counseling communication. For further suggestions, school principals should evaluate the teachers’ ability in counseling communication to children and implement teacher counseling communication through tutorials and training among colleagues or peer tutors among teachers.
East Kalimantan Madrasah Teachers’ Perception of Religious Moderation
Authors: Hamidy Anwaril , Azizah Yunita Noor , Iswanto Bambang
Published: January 2023

Efforts to strengthen religious moderation in the madrasah environment are strongly influenced by the madrasah teacher's perception of religious moderation. It relates to the extent of the socialization of religious moderation to madrasah teachers. The study aims to describe the socialization of religious moderation to madrasah teachers in East Kalimantan and their perceptions of the importance of religious moderation for students. An online survey was conducted of 73 madrasah teachers in East Kalimantan. The survey consists of two close-ended questions and one open-ended question. The answers of close-ended questions were processed and presented descriptively. The answers of open-ended questions were analyzed through the stages of reduction, data presentation and conclusions. The results showed that the majority of respondents (78%) have participated in socialization about religious moderation. Most respondents (91%) also agree that religious moderation is important for students. The reasons for the importance of religious moderation for students are to foster student tolerance, maintain the integrity of the nation, prevent extreme religious attitudes, adequate to the needs of the era, part of the obligatory of Allah SWT and so that students do not dichotomize between religious knowledge and general science. Even so, there are still teachers who doubt the importance of religious moderation for students. Therefore, efforts are needed to strengthen sustainable religious moderation in order to realize a common perception of religious moderation in the madrasah environment.
Online Learning at Islamic Elementary School amidst Pandemic: Implementation, Challenges, and Key Success Factors
Authors: Zurqoni Zurqoni , Saugi Wildan , Abdillah Muhamad Hasan , Susmiyati Sri
Published: January 2023

This study aimed to explore the implementation of online learning at Madrasah Ibtidaiyah in East Kalimantan during the pandemic including its challenges and key success factors. This research was a field research with a qualitative approach. This research was conducted in Samarinda, Balikpapan, and East Kutai involving 9 (nine) Islamic elementary schools (MI) in East Kalimantan using simple random sampling techniques. Data collection techniques used interview, observation, and documentation. Data were then analyzed through data display, data condensation, and conclusion drawing/verification, and presented using descriptive techniques. The results revealed that the planning of learning was through the 2013 curriculum simplification, the simplification of the syllabus and lesson plans, online learning training for teachers, preparation of facilities and infrastructure, and socialization. The implementation of learning was done by determining the time, using the learning management system (LMS), determining the appropriate method and media, applying a variety of learning, and giving assignments and assessments. Evaluation was seen from student attendance that was 60%-95%, KKM that only reached 67%, the obstacles faced, as well as solutions or follow-up carried out by schools to minimize the problems. The challenges were how to provide equal facilities and infrastructure, increase teacher, parent and student digital literacy, and to create meaningful interaction during online learning. The key success factors of online learning implementation at MI included the availability of adequate gadgets, internet data and stable internet network, consistent collaboration between teachers and parents, and readiness of teachers and students.
Internalization of Religious Moderation on Children at Raudhatul Athfal Samarinda
Authors: Musfiroh Imroh Atul , Fauzan Umar , Malihah Noor
Published: January 2023

This study aimed to analyze the process of internalizing the religious moderation values on children at an early age. The subjects of this research were principals, teachers, educational staff, parents and students at three Raudhatul Athfal schools in Samarinda. This research used qualitative design. Data collection was carried out for 2 months, from the beginning of February to the end of March 2022. Data obtained through observations, interviews, and documentation. The analysis of the data used the Miles and Huberman model that includes data condensation, data display, and conclusion and verification. The results showed that: 1) Planning of the internalization of religious moderation values on children ​​at Raudhotul Athfal Samarinda was through coordination between schools and stakeholders, identifying and determining school programs in accordance with the school curriculum, formulating materials regarding religious moderation values, formulating the planning of learning tools, 2) Implementation of internalization of the religious moderation values in learning was through the incorporation and strengthening of perspectives, mindsets and practices of religious moderation; curriculum development containing religious moderation through core competencies, building the values ​​of religious moderation through PAI and character education learning materials, 3) the results of the religious moderation value internalization were in the form of an understanding of the aswaja principles and moderate attitudes. It is expected that this research can give better insight related to the internalization of religious moderation values on children at an early age.
Implementation of Online Learning on PAI Subjects During the Covid-19 Pandemic
Authors: Ananiah Ananiah , Miftakhurrohmah Amalia
Published: January 2023

The purpose of this study was to find out how the implementation of online learning was and the supporting and inhibiting factors in the implementation of online learning in PAI Subjects in the middle of the Covid-19 Pandemic eleventh (XI) grade science students. This study used a qualitative method. Sources of data used were primary data in interviews with school principals, PAI teachers, and students of class XI science and secondary data in the form of books, journals, scientific articles, the internet, and other scientific works. Data collection techniques were in the form of observation, interviews, and documentation. The data analysis technique used the model of Milles and Huberman, including data collection, data reduction, data presentation, and concluding the data obtained. The results showed that the implementation of online learning on PAI subjects in the middle of the covid-19 pandemic in class XI IPA started from government policy through SE Kemendikbud No. 4 of 2020 concerning the Implementation of Education Policies in the Emergency Period for the Spread of the Corona Virus. The implementation of this learning is based on the 2013 curriculum syllabus and uses online lesson plans (RPP). In the learning process, used Whatsapp, Youtube, and Schoology applications. The teacher also made various learning materials and media such as PowerPoint and videos related to the material. The process of learning evaluation was conducted by giving assignments or practice questions. The supporting and inhibiting factors for the implementation of online learning were able to be seen from three aspects, namely: (1) Human Resources (HR), (2) Materials or teaching materials, and (3) Supporting facilities.
Desórdenes informativos y polarización afectiva: en un análisis de las emociones en publicaciones con desinformación en tres conflictos políticos brasileños en Twitter.
Authors: Santana Chaves Julia Marks , De Camargo Penteado Claudio Luis
Published: January 2023

El artículo presenta un estudio sobre la desinformación y la polarización afectiva en las plataformas digitales. La investigación analizó la presencia y el tipo de desórdenes informativos  y su relación con la movilización de emociones en 3 conflictos brasileños en Twitter: legalización del aborto, caso de racismo y apertura de investigación por irregularidades en acciones de combate a la Covid-19 en el país. Mediante técnicas computacionales de monitoreo, recolección y procesamiento de datos extraídos de la plataforma, se compuso una muestra de los 100 mensajes más compartidos de cada uno de los conflictos (n=300). Estas publicaciones fueron analizadas cualitativamente para identificar y clasificar el tipo de desórdenes informativos y verificar la movilización del marco de emociones en estos tweets con desinformación. Los resultados muestran que en los tres conflictos analizados fue posible identificar una gran cantidad de contenidos con desórdenes informativos entre los posts más compartidos y su estrecha relación con las emociones negativas (ira y asco), indicando la relación entre la desinformación y la polarización afectiva.
Neural and behavioral effects of parent training on emotion recognition in mothers rearing children with ADHD
Authors: Makita Kai , Yao Akiko , Shimada Koji , Kasaba Ryoko , Fujisawa Takashi X , Mizuno Yoshifumi , Tomoda Akemi
Published: January 2023

This randomized controlled study examined neurological changes in socioemotional processing skills through parent training in caregivers of children with attention-deficit/hyperactivity disorder. Thirty mothers of children with attention-deficit/hyperactivity disorder were stratified into parent training and non-parent training groups. Functional magnetic resonance imaging was performed during the “Reading the Mind in the Eyes” test, and parenting difficulties were evaluated using the Parenting Stress Index and the Parenting Scale, twice (before and after parent training). Only mothers in the parent training group showed a significant decrease in Parenting Stress Index and Parenting Scale scores. They also demonstrated increased activity in the left occipital fusiform gyrus during the task of estimating emotions from facial pictures, with a trend towards a reduced response time while judging others’ emotional state in the “Reading the Mind in the Eyes” test. We presumed that these changes might reflect that enrollment in parent training could reduce stress, which in turn might possibly reduce reaction times in processing others’ emotional states. Furthermore, these results may also be related to the increased activation of the fusiform gyrus.
Why Nations Prosper
Authors: Natadipurba Chandra
Published: January 2023

This paper's main idea is that Synechi causes prosperity. I define "Synechi" as "nation political leader implemented and reinforced a series of free-market policy continuously without substantial reverse for at least 20 years." I use: (1) the difference-in-difference method, using West Germany, South Korea, Botswana as the treatment group and East Germany, North Korea, and Zimbabwe, as the control group, to mimic "natural experiment", (2) Direct Method of Agreement from data of 52 countries and (3) Method of Difference form data of 24 countries and (4) Joint Method of Agreement and Difference, from data of 66 countries. I use Maddison Project Database data in the long- run GDP per capita published in early 2018 and other data sources. This approach is novel since previous papers only show that the free-market correlates with prosperity.
JEL Classification:
F59 O10 O11 O20 O21 POO
Effects of biochar combined with MgO desulfurization waste residue on nitrogen conversion and odour emission in chicken manure composting
Authors: Pang Yuwan , Zhen Feng , Wang Dehan , Luo Zifeng , Huang Jianfeng , Zhang Yanli
Published: January 2023

Aim
Chicken manure can readily produce much odour during aerobic composting. This odour pollutes the surrounding environment and represents the loss of nutrients such as nitrogen and sulfur, which reduces the fertilizer quality.
Methods
In this paper, biochar combined with MgO desulfurization waste residue (MDWR) was used as a new composting additive. Through composting tests, characterization analysis and pot experiments, the effect of additives in compost on nitrogen retention and deodorization was studied, the mechanism of in situ chemical deodorization was revealed, and the compost quality was verified.
Results
The results indicated that biochar and MDWR addition optimally reduced ammonia volatilization in chicken manure compost, and the reduction rate reached 60.12%. Volatile organic compound (VOC) emissions originating from chicken manure compost containing biochar and MDWR decreased by 44.63% compared to those originating from the control group.
Conclusions
The total nitrogen (TN) in the composting product containing chicken manure treated with both biochar and MDWR (CMB) was 67.7% higher than that in the composting product under the blankcontral, and this value was significantly higher than that under the other treatments and better reflected the synergistic effect of these two additives on nitrogen retention. Struvite crystals could be formed in the CMB treatment. According to the pot experiment results in terms of compost products, the CMB treatment increased the yield and quality of vegetables and reduced the nitrate content. Therefore, MDWR significantly affects nitrogen retention and deodorization of chicken manure compost while improving the compost quality; therefore, MDWR exhibits broad application prospects.
Comprehensive treatment strategy for banana inflorescence bract to synthesize biodiesel and bioethanol through fungal biorefinery
Authors: Bharathi Sundaram Deepika , Jacob Samuel
Published: January 2023

Banana inflorescence bract (BIB), an agro-waste is sporadically explored for second-generation biofuel production in spite of having considerable holocellulosic composition (cellulose-35.56%, w/w; hemicellulose-22.41%, w/w). In this study, an attempt has been made to utilize this substrate for fermentable sugar extraction (C5 and C6) which were employed for the co-production of microbial lipids and ethanol using Rhodosporidium toruloides NCIM 3547 and Saccharomyces cerevisiae respectively. Since, a considerable amount of lignin (8.78%, w/w) is present in BIB, a hybrid pretreatment and carbohydrate hydrolysis through microwave (160 W) assisted mild H2SO4 acid 2.5% (v/v) was adopted. The resultant liquor contains holocellulosic sugars (C5 and C6 sugars), out of which xylose (10.40 ± 0.49 g/L) and glucose (51. 48 ± 1.14 g/L). Hence, it was used as the growth medium for Rhodosporidium toruloides to produce lipids i.e., single cell oil (SCO). The maximum lipid content was found to be 41.59 ± 1.16 (%, w/w) containing total saturated fatty acids of 89.07% which justifies its potential application in biodiesel production. On the other hand, the pretreated solid fraction containing cellulose was saccharified using cellulolytic enzyme produced by Aspergillus sp. with saccharification of 69.99 ± 0.30 (%, v/w) and 27.22 g/L of reducing sugar. This enzymatic hydrolysate was used for ethanol production by Saccharomyces cerevisiae resulting in an ethanol yield of 12.70 ± 0.09 (g/L) and productivity of 0.132 g/L/h. BIB is a potential feedstock and thereby, paving a sustainable route for agro-waste management by favouring integrated production of biodiesel and bioethanol towards a biorefinery approach.
Exosomal miR-320e is a potential target of CVSD that regulates the Wnt2-mediated Wnt/β-catenin signaling pathway
Authors: Wang Zheng , Li Xuening , Yang Shaonan , Wang Yuan , Gao Kejin , Han Bin , Ma Aijun
Published: January 2023

Exosomal miRNAs play crucial roles in many central nervous system diseases. Cerebral small vessel disease (CVSD) is a small vessel disease thatis affected by various factors. In the present study, we investigated the role of exosomal miR-320e in theWnt/β-catenin pathway stimulated by oxidative stress and assessed its role in CVSD.
The differentially expressed exosomal miRNAs were filtered by sequencing plasma exosomes from CVSD patients and healthy controls. Bioinformatic and dual luciferase analyses were used to confirm the relationship between Wnt2 and miR-320e. Quantitative real-time PCR and Western blotting were used to detect the mRNA and protein levels of Wnt/β-catenin pathway components. Membrane fluorescence staining was used to detect exosome transfer.
High-throughput sequencing showed that exosomal miR-320e was downregulated. Bioinformatics analysis and dual-luciferase reporter gene experiments showed that exosomal miR-320e regulated Wnt2expression by targeting the 3' noncodingregion of Wnt2. Exosomal miR-320e was found to mediate the response of the Wnt/β-catenin signaling pathway to oxidative stress through loss-of-function experiments using mimics, inhibitors and knockdown/overexpression lentivirus. Exosomal miR-320e could target and inhibit the Wnt2/β-catenin signaling pathway.
Our research suggests that exosomal miR-320e is a suppressor of the Wnt/β-catenin signaling pathway and may play a protective role in the progression of CVSD.
Clinical trial registration
Not applicable
Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease
Authors: Jenq Robert , Hayase Eiko , Hayase Tomo , Mukherjee Akash , Stinson Stuart , Jamal Mohamed , Ortega Miriam , Sanchez Christopher , Ahmed Saira , Karmouch Jennifer , Chang Chia-Chi , Flores Ivonne , McDaniel Lauren , Brown Alexandria , El-Himri Rawan , Chapa Valerie , Tan Lin , Tran Bao , Pham Dung , Halsey Taylor , Jin Yimei , Tsai Wen-Bin , Prasad Rishika , Glover Israel , Ajami Nadim , Wargo Jennifer , Shelburne Samuel , Okhuysen Pablo , Liu Chen , Fowler Stephanie , Conner Margaret , Peterson Christine , Rondon Gabriela , Molldrem Jeffrey J , Champlin Richard , Shpall Elizabeth , Lorenzi Philip , Mehta Rohtesh , Martens Eric , Alousi Amin
Published: January 2023

Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment response of aGI-GVHD and the intestinal microbiota has not been well-studied. In a cohort of patients with aGI-GVHD (n=37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and loss of Bacteroides ovatus from the microbiome. In a mouse model of carbapenem-aggravated GVHD, introducing Bacteroides ovatus reduced severity of GVHD and improved survival. Bacteroides ovatus reduced degradation of colonic mucus by another intestinal commensal, Bacteroides thetaiotaomicron, via its ability to metabolize dietary polysaccharides into monosaccharides, which then inhibit mucus degradation by Bacteroides thetaiotaomicron and reduce GVHD-related mortality.
Does Renewable Energy Improve Environmental Quality? Evidence from RECAI Countries
Authors: Raghutla Chandrashekar , Kolati Yeliyya
Published: January 2023

Since 1990, the ecological footprints have been increasing significantly with a continuous increase rate, which led to challenges to environmental quality. The basis for Economic growth was said to be the shift of energy and environmental strategies toward a sustainable future. Indeed, it became a matter of proclaimed acceptance that environmental challenges nurtured expansion, innovation, and competitiveness. Climate change is the most pressing issue being faced by the world due to an increase in ecological footprint from 7.0 billion GHA to 20.6 billion GHA. It indicates the seriousness of environmental degradation; therefore, the nations need to ensure environmental sustainability. Keeping this in mind, the present research main aims to examine the impact of renewable energy utilization on the ecological footprints of RECAI economies, spanning the period 1990 to 2020. To significantly achieve the research objective, we utilized panel econometric methods for empirical analysis. The results of long-run elasticities indicate that both the renewable energy utilization as well as trade openness significantly controls the ecological footprints, while higher conventional energy utilization and economic growth significantly impede the environmental sustainability. The empirical findings provide new insights for policymakers on renewable energy for the betterment of environmental quality in RECAI countries.
Implementation of the Expectation–Augmented Phillip’s Trade-off to Create an Inflation Path that Minimize Social’s Loss Function: Evidence from Indonesia
Authors: Susilowati MG Westri Kekalih
Published: January 2023

The Phillip’s curve shows the trade-off between inflation and unemployment. The problem of unemployment so far echoes inferior to inflation rate. This study aims to prove the existence of the Philips curve in Indonesia and implement the Expectation–augmented Phillips trade-off to build an inflation rate path that minimizes Social’s Loss. In creating the inflation path, this study adopts the social's loss function model by Taylor. The results show that Indonesia's Phillips curve did exist from 1976 to 1996. However, it no longer exists during the next period, 2000 to 2022. Implementation of the Expectation–augmented Phillips trade-off results that based on the actual inflation rate at the end of 2022 of 6 percent, the yearly inflation rate should be at 4.79, 3.98, or 3,64 percent. Meanwhile, based on the inflation target in the fiscal note 2023, the yearly inflation rate should be 2.39, 1.99, or 1.82 percent.
JEL Classification Code: E31, E37, E53
Alginate-chitosan hydrogels containing shRNA plasmid for inhibition of CTNNB1 expression in breast cancer cell
Authors: Cömez Birnur , Özbaş Suna
Published: January 2023

Objectives
The hydrogels prepared with alginate and chitosan polymers were aimed to deliver the shRNA-encoding plasmid (pshRNA) to MDA-MB-231 cells for the inhibition of β-catenin (CTNNB1) which was reported to be over-expressed in breast cancer.
Methods
Polyion complex hydrogels prepared using varying concentrations of sodium alginate and chitosan were characterized by Fourier transform infrared spectrometry (FTIR) analysis, scanning electron microscope (SEM) image, swelling properties, and viscosity. After the release properties, serum stability, and in vitro degradation rates of pshRNA-loaded hydrogels were determined, their cytotoxicity, transfection efficacy, and effects on CTNNB1 expression were investigated in MDA-MB-231 cells.
Results
All hydrogels were shown to protect pshRNA from the enzymatic activity of serum and to deliver pshRNA to cells efficiently. As a result of transfection studies, pshRNA-loaded hydrogels reduced CTNNB1 expression by up to 30.25%. Cell viability also decreased by 38% in cells treated with 2.5% (w/v) alginate-chitosan hydrogel containing pshRNA targeting CTNNB1.
Conclusions
Alginate-chitosan hydrogels were shown to be a suitable matrix system for local gene delivery.
Electronic manipulating in hydrated electron simulation of the carbon-halogen bond reductive cleavage
Authors: Li Kaixin , Chen Zhanghao , Jin Xin , Tian Haoting , Song Zhenxia , Zhang Qingyun , Xu Dayong , Hong Ran
Published: January 2023

Hydrated electron e−(aq) reaction with the alkyl halide and aryl halide was simulated synergistically with ab initial molecular dynamics (AIMD) in this study to reveal the morphological and dynamics mechanism. An original method was developed for preparing the proper initial wavefunction guess of AIMD, in which the extra electron was curled properly in a tetrahedral cavity of four water molecules. Our results indicated that the tetrahedral structure of e−(aq) (THE*) is more stable than the prism structure e−(aq) (PHE*) from the energy aspect. The interior weak interaction in THE* is mainly between the hydroxyl group with the extra electron, while the PHE* structure stability is attributed to the weak H-H interaction. The extra electron, with a significant sigma characteristic, collapses in a cavity composed of water molecules in these two structures and has a probability of collapsing to a certain sole water, this probability is inversely proportional to the number of waters; Organic halides prefer the direct reaction with e−(aq) in a neutral or alkaline environment while the hydrogen radical would be the dominant reaction species in an acidic solution. Fluorobenzene and fluoromethane are the hardest molecules to accept the extra electron and also have the highest reaction barriers during the hydrogen radical reactions; AIMD suggested that the LUMO or higher orbitals were the e−(aq) migration destination. The transplanted electron enhanced C-halogen bond vibration before the cleavage actually occurred. The solvation of the departing halogen anions was observed in both fluorobenzene and fluoromethane AIMD, indicating it might have a significant effect on enthalpy. A deformation of fluoromethane product, the methane radical, was detected from the sp3 structure to the sp2 plane structure, resulting in larger energy differences during the reaction than aryl halides. The study provided theoretical insight into the pollutant environmental fate and placed a methodological foundation for AIMD simulation of analogous free radical reactions.
Construct Validity of the Psychosis Screening Questionnaire in Ugandan Adults
Authors: Kwagala Claire , Ametaj Amantia , Kim Hannah H. , Kyebuzibwa Joseph , Rogers Okura , Stevenson Anne , Gelaye Bizu , Akena Dickens
Published: January 2023

Background: Psychotic disorders are common and contribute significantly to morbidity and mortality of people with psychiatric diseases. Therefore, early screening and detection may facilitate early intervention and reduce adverse outcomes. Screening tools that lay persons can administer are particularly beneficial in low resource settings. However, there is limited research evaluating the validity of psychosis screening instruments in Uganda. We aimed to assess the construct validity and psychometric properties of the Psychosis Screening Questionnaire (PSQ) in Uganda in a population with no history of a psychotic disorder.
Methods: The sample consisted of 2101 Ugandan adults participating as controls in a larger multi-country case-control study on psychiatric genetics. We used confirmatory factor analysis (CFA) and item response theory (IRT) to evaluate the factor structure and item properties of the PSQ.
Results: The overall prevalence screening positive for psychotic symptoms was 13.9%. “Strange experiences” were the most endorsed symptoms (6.6%). A unidimensional factor was the best fitting model based on the fit indices including the root mean square error of approximation (RMSEA of 0.00), comparative fit index (CFI of 1.000), and Tucker-Lewis Index (TLI of 1.000). The most discriminating items along the latent construct of psychosis were items assessing thought disturbance followed by items assessing paranoia, with a parameter (discrimination) value of 2.53 and 2.40, respectively.
Conclusion: The PSQ works well in Uganda as an initial screening tool for moderate to high-level of psychotic symptoms.
Anterior insula glutamate/glutamine is associated with psychopathology scores through overestimating errors
Authors: Park Haeorm , Kim Minchul , Kim Jaejoong , Kim Sunghwan , Jeong Bumseok
Published: January 2023

Despite having more direct information with functional magnetic resonance spectroscopy (fMRS), little is known about how the brain’s neurochemical mechanisms influence mental health and decision-making. In this study, we examined whether baseline glutamate/glutamine (Glx) and lactate concentrations were related to general anxiety and depression and how they changed according to gains and losses with fMRS scanning during reward learning and computational modeling. The Glx concentration in the anterior insular cortex (AIC), not the medial prefrontal cortex, was positively associated with the general psychopathological factor of anxiety and depression through the mediation of error sensitivity. The AIC Glx level decreased mainly after learning from gains and as the entire task was performed. Conversely, lactate reduction in AIC occurred only during learning from losses and was associated with higher general psychopathology scores. We demonstrated for the first time that both glutamate-related error sensitivity and loss-specific lactate reduction in the AIC are associated with general psychopathology. This study’s results suggest that the AIC is a potential target brain region for glutamate and/or lactate-mediated therapeutics for anxiety and depression.
Mixed-linker strategy for suppressing structural flexibility of MOF membranes for gas separation
Authors: Chang Chung-Kai , Ko Ting-Rong , Lin Tsai-Yu , Lin Yen-Chun , Yu Hyun Jung , Lee Jong Suk , Li Yi-Pei , Wu Heng-Liang , Kang Dun-Yen
Published: January 2023

Structural flexibility is a critical issue that limits the applications of MOF membranes for gas separation. Herein we propose a mixed-linker approach to suppress the structural flexibility of the CAU-10-based membranes. Specifically, pure CAU-10-PDC membrane is of high separation performance but at the same time highly unstable for the separation of CO2/CH4. A partial substitution (30 mol.%) of the linker PDC with BDC significantly improves its stability. Such an approach also allows for the aperture size of MOFs. The optimized CAU-10-PDC-H (70/30) membrane possesses a high separation performance for CO2/CH4 (separation factor of 76 and CO2 permeability of 1,111 Barrer under 2 bar of feed pressure at 35 ℃). A combination of in situ characterization with XRD and DRIFT spectroscopy, as well as DFT calculations, unveils the origin of the mixed-linker approach to enhancing the structural stability of the mixed-linker CAU-10-based membranes during the gas permeation tests.