bluuebunny/crossref_metadata_2025 huggingface dataset:
INCORPORATION OF HYBRID BIOFILTERS IN WATER-SENSITIVE URBAN DESIGN
Authors: Brenner Asher , Cohen Hodaya , Gradus Or , Koren Oshrat , Shandalov Semion , Zinger Yaron
Published: November 2020

This paper presents a research study aimed at the development of a hybrid biofilter that can serve for two different applications. This is a unique approach due to the prolonged dry period in Israel covering 7-8 months of the year. The tactic suggested herein is to use the same system for stormwater harvesting/treatment during winter, and for bioremediation of nitrate-contaminated groundwater during summer. Crude cotton and Eucalyptus wood-chips served as alternative carbon sources for denitrification, and both proved to support efficient reduction of nitrate with minimal release of nitrite and organic matter. During the stage of stormwater treatment, two types of biofilter-columns (120 & 70 cm long) were tested, with a minimal saturation zone and no addition of organic carbon. Complete nitrification could be achieved, even under high instantaneous hydraulic loads for both column types. Vegetation on top of the biofilters contributed to improved removal of the nitrate formed, by plant assimilation.
VULNERABILITY TO CLIMATIC RISKS IN NATIONAL AND LOCAL ASPECTS
Authors: Răileanu Valentin , Nedealcov Maria , Mîndru Galina , Cojocari Rodica , Crivova Olga
Published: November 2020

Republic of Moldova’s territory’s Livelihood Vulnerability Index (LVI), calculated from exposure, sensitivity and adaptive capacity to climate risks, is presented. Extreme values of climate risk factors, water supply, and statistical data on socio-demographic profile were used as the initial data. As a case study, LVI and its components for the Cogâlnic River’s basin within the limits of Republic of Moldova’s boundaries was extracted from the obtained maps.
Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction
Authors: Ponasenko A. V. , Khutornaya M. V. , Malyshev I. Yu. , Barbarash O. L.
Published: November 2020

Aim. To determine the relationship between the serum interleukin (IL) 18 level, the carriage of variant alleles IL18, IL18R1, IL18RAP and the risks of myocardial infarction (MI), hypertension, multifocal atherosclerosis in patients with stable coronary artery disease (CAD).

Material and methods. Two hundred and sixty patients with stable coronary artery disease living in a large industrial region ofWestern Siberia were examined. Serum IL18 concentrations was determined by the enzyme immunoassay. Genotyping was performed by real-time polymerase chain reaction using TaqMan technology.

Results. We revealed associations of rs13015714 IL18R1 and rs917997 IL18RAP sites with the MI risk (odds ratio (OR), 1,95 [95% confidence interval (CI), 1,063,58], p=0,029; OR, 2,01 [95% CI, 1,11-3,64], p=0,018, respectively). Associations of rs13015714 and rs917997 sites with high IL18 concentrations (genotypes C/T + T/T 488,0 [321,0, 687,2] pg/ml and T/G + G/G 504,2 [275,6; 655,5] pg/ml) was observed.

Conclusion. The relationship between the minor alleles of rs13015714 IL18R1 and rs917997 IL18RAP sites with an increased risk of MI in patients with stable CAD was shown. Also, polymorphism at rs13015714 and rs917997 sites provides different levels of circulating IL18. In particular, the carriage of minor alleles is associated with increased IL-18 levels in patients with previous MI and multifocal atherosclerosis or hypertension, as well as with an increase in the risk of these pathologies.
Some pro- and anti-inflammatory cytokines, their genetic polymorphism and postinfarct cardiac remodeling
Authors: Nikolaeva A. M. , Babushkina N. P. , Ryabov V. V.
Published: November 2020

The role of molecular genetic factors in cardiovascular disease (CVD) development has been actively studied in recent years. In patients with acute myocardial infarction and heart failure, the genetic component contributes to the determination of inflammation and persistence of inflammatory mediators in the myocardium. The genetic component in combination with traditional CVD risk factors determines the clinical course of the disease, the severity and its outcome. This review summarizes the data on relationship of proand anti-inflammatory cytokines with coronary artery disease and its clinical manifestations.
Deoxyribonucleic acid methylation in the enhancer region of the CDKN2A/2B and CDKN2B-AS1 genes in blood vessels and cells in patients with carotid atherosclerosis
Authors: Koroleva Yu. A. , Markov A. V. , Goncharova I. A. , Sleptsov A. A. , Babushkina N. P. , Valiakhmetov N. R. , Sharysh D. V. , Zarubin A. A. , Kuznetsov M. S. , Kozlov B. N. , Nazarenko M. S.
Published: November 2020

Aim. Comparative analysis of the deoxyribonucleic acid (DNA) methylation level in the enhancer region of the CDKN2A/2B and CDKN2B-AS1 genes (9p21.3 locus) in vessels with/without atherosclerotic lesions, as well as in leukocytes of patients with clinically relevant carotid artery (CA) atherosclerosis and healthy individuals.

Material and methods. The group of patients with clinically relevant atherosclerosis included 22 individuals with severe stenosis (>80%) of CA. Samples of atherosclerotic plaques, presenting CA regions, and great saphenous veins, as well as peripheral blood samples (leukocytes) were obtained from patients. The control group consisted of 14 individuals with the mild CA stenosis (£24%) and without hemodynamically relevant changes; peripheral blood samples were obtained from each of them. DNA methylation level was assessed by targeted bisulfite sequencing of amplicons.

Results. The tissue-specific methylation of 31 CpG-site in the CDKN2A/2B and CDKN2B-AS1 gene enhancer was established: the vascular tissues significantly differed from the peripheral blood leukocytes. At the same time, there was an increase in the methylation level of both certain CpG sites and whole analyzed CA region affected by atherosclerosis (48,6 [34,8; 62,0]%), compared with intact vessels, both arteries (25,2 [23,1; 41,60]%, p=0,0001) and veins (35,0 [31,6; 40,0]%, p=0,0039). Patients had lower methylation levels in all CpG sites in blood leukocytes compared to blood vessel samples (8,7 [6,1; 9,7]%; p<0,05). At the same time, the level of DNA methylation in the blood leukocytes of atherosclerotic patients does not differ from that in healthy individuals (9,3 [8,3; 13,6]%; p>0,8).

Conclusion. In the present study, the relationship between an increase in the DNA methylation in the enhancer of the CDKN2A/2B and CDKN2B-AS1 genes in CA and their atherosclerotic lesions was revealed, as well as the tissue-specific DNA methylation between vessels and peripheral blood leukocytes.
Distance learning in cardiology: the use of multimedia clinical diagnostic tasks
Authors: Karas S. I. , Grakova E. V. , Balakhonova M. V. , Arzhanik M. B. , Kara-Sal E. E.
Published: November 2020

Aim. To create a methodological base for distance learning of cardiology healthcare professionals — multimedia clinical diagnostic tasks.

Material and methods. The interdisciplinary team used text and multimedia formats for clinical diagnostic data. Web technologies provided remote access to information located on the server.

Results. The report presents the experience of the practical implementation of multimedia clinical diagnostic tasks in cardiology, including the augmented reality. The variability of presenting information to students is implemented in the multimedia clinical diagnostic tasks, which is integrated with the rating system for evaluating decisions. The solution paths are determined by the actions of the students in the trigger interactive blocks and is evaluated by the rating system. Personal rating is a numerical value that integrally characterizes the decisionmaking competence of students. The conversion of the quantitative rating into the conventional form (‘pass/fail’, ‘excellent’, ‘good’, ‘passing grade’) will be provided after the trial period of the software.

Conclusion. The created Web service and computer simulations can become a methodological basis for the distance learning in cardiology. This technology can be in demand in the continuing medical education.
Effect of dapagliflozin in patients with heart failure on reducing cardiovascular mortality in federal project on the prevention of cardiovascular diseases
Authors: Zhuravleva M. V. , Tereshchenko S. N. , Zhirov I. V. , Villevalde S. V. , Marin T. V. , Gagarina Yu. V.
Published: November 2020

Aim.To assess the effect of dapagliflozin in patients with heart failure with reduced ejection fraction (HFrEF) on reducing cardiovascular mortality as the main goal of a federal project on the prevention of cardiovascular diseases.

Material and methods.All adult Russian patients with a documented NYHA class II-IV HFrEF (EF £40%) were considered the target population. The characteristics of the patients corresponded to those of the Russian Hospital Heart Failure Registry (RUS-HFR). The study looked at an increase in the dapagliflozin use in addition to standard therapy by 10% of patients annually in 2021-2023 and calculated the number of deaths that could be prevented. Cardiovascular mortality curve was created by extrapolation of the DAPA-HF study results using the Kaplan-Meier method. Further, the contribution of prevented deaths with dapagliflozin to the achievement of regional and federal targets for reducing cardiovascular mortality was calculated for 1, 2, and 3 years.

Results.In case of 10% annual increase in dapagliflozin use in patients with NYHA class II-IV HFrEF, this will allow:

—   to prevent an additional 1,736 cardiovascular deaths in the first year, achieving the target of federal project on the prevention of cardiovascular diseases in 2021 by 5,9%;

—   to prevent an additional 3,784 cardiovascular deaths in the second year, achieving the target of federal project on the prevention of cardiovascular diseases in 2022 by 12,9%;

—   to prevent an additional 5,485 cardiovascular deaths in the third year, achieving the target of federal project on the prevention of cardiovascular diseases in 2023 by 18,7%.

Conclusion.The use of dapagliflozin in patients with HFrEF will reduce mortality from cardiovascular diseases.
Türkiye’de Çocuk İstismar ve İhmaline İlişkin Hemşirelik Alanındaki Lisansüstü Tezlerin İncelenmesi
Authors: KAPLAN Bahriye , ÇALIŞKAN Zehra , EVGİN Derya
Published: November 2020

Bu çalışma ülkemizde çocuk ihmal ve istismarına ilişkin hemşirelik alanında yapılan lisansüstü tezleri incelemek amacıyla yapılmıştır. Tanımlayıcı özellikte olan çalışmada, Yüksek Öğretim Kurumu Ulusal Tez Merkezi Veri Tabanına “çocuk ihmali”, “çocuk istismarı”, “istismar”, “ihmal” “ihmal ve istismar”, anahtar kelimeleri ile 2010-2017 yıllarına ait “Hemşirelik” Ana Bilim Dalındaki lisansüstü çalışmalar incelenmiş ve 15 çalışma, araştırma kapsamına alınmıştır. Çocuk istismar/ihmalini araştıran lisansüstü tezlerin sadece %26.6’sı (n=4) doktora tezi olup geri kalan tezlerin tamamı yüksek lisans tezleridir. Çocuk ihmal ve istismarının, ebeveyn eğitim durumları, ailelerindeki sosyo-ekonomik yetersizlikler ile ebeveynlerin kendi çocukluklarında ihmal ve istismara maruz kalma durumu ile yakından ilişkili olduğu bulunmuştur.
Investigation of Social Studies Curriculum in Regards to Migrant, Refugee, Asylum-Seekers Concepts
Authors: KILCAN Bahadır , ŞİMŞEK Ünal
Published: November 2020

This study aims to exhibit the current situation of migrant, refugee, asylum-seekers concepts in Social Studies Curriculum (2018) in Turkey in detail. This study, in which qualitative research method was applied, used document review for the detailed examination of the social studies curriculum. It referred to descriptive analysis technique in the analysis of the data obtained. The results of the research show that the concepts of migrant, refugee, asylum-seekers are not included in the social studies curriculum at all. The six criteria discussed (special purposes, basic skills, values, achievements of the social studies curriculum, issues to be considered in the implementation of the curriculum, the structure & learning areas of the curriculum), partially found a place directly or indirectly in the curriculum. However, there is a disproportionate distribution as seen in the findings. While 11 out of 18 values in the values section, 4 out of 7 learning areas can be associated with the concepts of migrant, refugee, asylum-seekers in a direct or indirect fashion, merely 15 out of 27 skills and only 15 out of 131 total achievements are associated with these concepts. Thereupon, the study reveals that the number of items, particularly the number of achievements, is insufficient in terms of concepts discussed whilst schools treat courses subject and achievement centered. In this respect, the researcher suggests that the distribution rates of migrant, refugee, asylum-seekers concepts should be more balanced in the curriculum amongst the criteria discussed in the study. A learning area for inclusive education should be created that includes all disadvantaged individuals directly. Accordingly, special purposes, issues to be considered in the implementation of the program, values, skills and achievements should be updated in the social studies curriculum (2018).
NoDOS(3) Calling!! Propuesta de trazos, huellas y recorridos como resultado de una residencia artística online
Authors: Torrecilla Elia , Ghetti Cristina
Published: November 2020

En el presente fotoensayo se comparte un proyecto artístico intermedia, realizado en The Spectacular House, una plataforma de divulgación de arte y pensamiento, comisariada por Sofia Caetano y establecida en Pittsburgh (USA) y Ponta Delgada (Azores). Su labor se muestra en una página web creada con el objetivo de promover el arte y la cultura de manera virtual a escala global. Dentro de esta plataforma, se encuentra “Gate”, una puerta que se abre hacia una galería de arte online donde se alojan proyectos site specific y proyectos generados en Internet como parte del proceso desarrollado en un entorno de residencia artística online. Y es dentro de este contexto donde el Grupo NoDOS(3), formado por Cristina Ghetti y Elia Torrecilla, desarrolló un proyecto durante dos semanas. El resultado final es una pieza digital, con una fuerte presencia de lo sonoro, donde las interacciones del usuario, las experiencias de desplazamientos, hipervínculos, vídeos, fotos y recorridos múltiples permiten visualizar un trabajo de naturaleza híbrida, de una manera diferente y creativa.

 

En este fotoensayo, se propone una visualización del proyecto a través de imágenes que muestran nuestro proceso de trabajo y que permiten al lector atravesar la pantalla a través del hipervínculo. De este modo, el visitante podrá participar de las investigaciones que NoDOS(3) llevamos a cabo, y que están basadas en el uso del cuerpo y la tecnología en el espacio (físico, virtual e híbrido) a través de la performance. En definitiva, ofrecemos la posibilidad de que el visitante realice un recorrido de manera lúdica e interactiva a través de un fotoensayo a golpe de “click”.
DIÁLOGOS SOBRE A EXPOSIÇÃO “OCEANOS”: UM ESTUDO COM FAMÍLIAS NO MUSEU DA VIDA.
Authors: Guimarães Vanessa F. , Massarani Luisa , Velloso Rafael , Amorim Denyse
Published: November 2020

Este artigo apresenta os resultados de um estudo qualitativo com famílias que visitaram a exposição “Oceanos” no Museu da Vida, um museu interativo no Rio de Janeiro. A exposição teve como objetivo informar e sensibilizar o público sobre os oceanos abordando sua diversidade ambiental, riqueza e biodiversidade e a ameaça a sua preservação representada pelas atividades antropogênicas. As visitas de dez grupos familiares foram registradas em vídeo e suas conversas analisadas utilizando o software Dedoose® buscando compreender os processos de apropriação da exposição por parte dos visitantes. A exposição “Oceanos” conseguiu atrair a atenção dos visitantes, que se mantiveram bastante interessados e focados na experiência durante toda a visita. Os resultados sugerem que houve uma apropriação dos conteúdos da exposição, por parte dos grupos familiares, num processo colaborativo socialmente mediado e que o objetivo de sensibilizar o público para questões ambientais, como por exemplo o lixo marinho, foi alcançado.
POLÍTICAS PÚBLICAS DO CENTRO DE APOIO E ACOMPANHAMENTO À INCLUSÃO: INTEGRAÇÃO OU INCLUSÃO ESCOLAR?
Authors: De Oliveira Huertas Andreia Patricia , Florencio da Silva Maria Camila , Candia Hollnagel Heloisa
Published: November 2020

A Meta 4 do Plano Nacional de Educação no Brasil (2014-2024) se propõe a assegurar os direitos educacionais das pessoas com deficiência, com a garantia de sistema educacional inclusivo e serviços especializados, públicos ou conveniados. O objetivo deste artigo é estudar as condições de implantação das políticas públicas em Educação Especial desenvolvidas pelo Centro de Formação e Acompanhamento à Inclusão - CEFAI, da Secretaria Municipal de Educação de São Paulo/SP, de forma a identificar princípios e características que indiquem práticas de integração ou inclusão escolar. Para tal, foi realizada a análise dos documentos oficiais referentes a esta instituição, complementada pela bibliografia específica sobre o tema. Os resultados indicam que as políticas de atendimento do CEFAI se coadunam à perspectiva de educação inclusiva, a qual garante o acesso e permanência das crianças e jovens com necessidades educacionais especiais em salas de aulas regulares de ensino sem, contudo, ser uma prática inteiramente consolidada.
POSSIBILIDADES E LIMITES DA UTILIZAÇÃO DO FACEBOOK COMO UMA FERRAMENTA DE CONSTRUÇÃO DE DIÁLOGOS E SABERES ENTRE MULHERES
Authors: Bueno Winnie , Burigo Joanna
Published: November 2020

A democratização do acesso à internet possibilitou aos movimentos sociais uma nova forma de articulação. Nesse sentido, as ativistas dos movimentos de mulheres encontraram no uso do Facebook, uma outra possibilidade de fomentar as bases necessárias para o crescimento do conhecimento individual e coletivo. Assim, partindo de uma visão não essencialista, buscamos neste artigo compreender se a utilização das ferramentas comunicativas disponíveis no Facebook auxilia na compreensão de linguagens distintas e estratégias de resistência na luta pelo combate ao sexismo e racismo. A partir de uma metodologia que privilegia as vivências das autoras, analisamos as formas com que as mulheres negras e não-negras formulam saberes e diálogos catalisadores de mobilizações que se pautem de forma não-hierarquizada. Utilizamos nessa análise perspectivas do feminismo negro que discorrem sobre o papel do feminismo na emancipação de mulheres subalternas
IDOSOS HOSPITALIZADOS POR FRATURAS: UM OLHAR SOBRE A ESTRUTURA FAMILIAR E OS ASPECTOS SOCIAIS
Authors: Dos Santos Maria Florência , Santana Vivia Santos , Duarte Suely Souza , Bezerra Shirleide Araújo
Published: November 2020

A população idosa cresce significativamente, e por ser a família a principal instituição responsável por cuidar de seus membros, a pessoa idosa passa a maior parte do seu tempo convivendo com seus familiares. Assim, procurou-se as principais causas sociais e culturais que podem provocar quedas nas pessoas idosas admitidos em um hospital filantrópico, verificando para tanto a estrutura familiar e a relação existente com os fatores direcionados à queda. A metodologia utilizada teve base na pesquisa bibliográfica e na aplicação de questionário estruturado. Além disso, o trabalho se caracteriza por ter uma natureza descritiva e exploratória, sendo ainda de caráter quantitativo e qualitativo. Diante do exposto, torna-se perceptível como resultado que as pessoas idosas acometidas de quedas, principalmente do sexo feminino, residem com familiares (em sua maioria), ou em alguns casos moram com amigos. O principal local de queda é na própria residência. As famílias são a principal fonte de cuidados das pessoas idosas, sejam estas dependentes ou não; no entanto, elas necessitam de maior orientação para a prestação de cuidados. É necessária uma avaliação socioeconômica da família e da pessoa idosa, de modo que seja possível oferecer subsídios para o planejamento das intervenções da equipe multiprofissional. Desse modo, o Estado estruturou uma rede de suporte para famílias que possuem pessoas idosas e podem necessitar de assistência. É necessário também mais pesquisas sobre a temática e sua divulgação por meio de palestras socioeducativas, o que poderá contribuir para a prevenção e recuperação das pessoas idosas vítimas de quedas.
SEIS HIPÓTESES CONFIGURADORAS DE CLÁUSULAS DE BARREIRA PARA A EFETIVIDADE NO PROCESSO DE ENSINAGEM JURÍDICA NO BRASIL
Authors: Leal Valtecino Eufrásio , Da Silva Sales Paulo Alberto , De Oliveira Vieira Geruza Silva , Leal Marilda Ferreira Machado
Published: November 2020

A partir da análise do quantitativo de cursos jurídicos existentes no Brasil, procura-se por meio desta pesquisa, teorizar sobre seis hipóteses demonstrativas da inviabilidade de bons resultados nos cursos jurídicos do país. A primeira delas passa pelo alto número de cursos autorizados e reconhecidos. A segunda, é inerente ao empirismo e ao tecnicismo adotados pelos docentes em sala de aula. A terceira versa sobre o conflito de linguagem e de comunicação entre as duas gerações que dificulta o processo de ensino-aprendizagem. A quarta tem como foco a relação ou o vínculo de trabalho dos professores com as instituições, que em larga escala, são agentes públicos ou profissionais autônomos, que adotam a docência como segunda profissão ou complemento de renda. A quinta questiona o fato do MEC realizar visitas e inspeções às instituições e aos cursos jurídicos, apenas trienalmente e a última, relaciona-se com a oferta de cursos, apenas em turnos noturnos. O objetivo da investigação é proporcionar diálogos acadêmicos que venham ampliar-se em favor de melhoras no ensino jurídico.
RESISTÊNCIA E REINVENÇÃO NOSCOM OS COTIDIANOS ESCOLARES PRÁTICAS SABERES DOCENTES FACE A UMA ONDA DE ATAQUE ULTRACONSERVADOR
Authors: Cotta Leonardo Rafaela , Pocahy Fernando , Martins Aline
Published: November 2020

: O presente trabalho busca, a partir de conversas com educadores perseguidos pelo ESP no espaço escolar, demonstrar as tensões emergidas no cotidiano docente, influenciadas pela conjuntura política nacional – vivenciadas nos anos de 2015 a 2017. A política e a chamada “Escola Sem Partido” se movimentaram neste interstício desde fortes estratégias de contensão da liberdade discursiva dos profissionais da educação dentro e fora das instituições escolares. No caminhar da escrita do trabalho percebe-se que os espaços educacionais tiveram um investimento de controle e de difamação nos últimos governos, alertando os perigos que a escola corre ao ter um posicionamento político e ideológico, sobretudo, de esquerda. E, contraditoriamente a esse discurso, coube ao movimento Escola Sem Partido partidarizar a instituição escola desde seus princípios unívocos em oposição à multiplicidade do pensamento-político-e-intelectual.
DA PRÁTICA AOS RECURSOS TECNOLÓGICOS: CONSIDERAÇÕES ACERCA DA MATEMÁTICA NO ENSINO MÉDIO
Authors: Richter Ana Patrícia Henzel , Wunsch Luana Priscila , Bottentuit Junior João Batista
Published: November 2020

A Matemática, assim como as demais disciplinas que compõem a grade curricular da Educação Básica brasileira, é tema frequente nos debates e discussões dos encontros de educadores em diversas partes do nosso país. Quando realizamos um olhar para o estado do Rio Grande do Sul, observa-se que muito ainda precisa ser feito, para que os índices que refletem a qualidade do que é ensinado e aprendido, nas linguagens e na Matemática, aponte um real desenvolvimento educacional. Diante disso, este trabalho apresenta como tema, as operações com números relativos, e o objetivo geral foi analisar as possíveis deficiências com esses tipos de cálculos, envolvendo as quatro operações (soma, subtração, multiplicação e divisão), cuja conceituação é oriunda do Ensino Fundamental, por alunos do primeiro ano do Ensino Médio, e correlacionou-se com o grau de dificuldade de aprendizagem dos conteúdos posteriores da Matemática. A metodologia utilizada foi um estudo de caso exploratório, com abordagem quanti-qualitativa in loco. O universo (população) da pesquisa é referente as turmas do primeiro ano do Ensino Médio diurno, de uma escola pública estadual de Palmeira das Missões (RS). Como resultado, provocou-se a reflexão dos professores atuantes da área de Matemática na referida escola, com o intuito de buscar novas práticas didáticas, pedagógicas e metodológicas, bem como suas tecnologias, para diminuir, ou mesmo suprimir, os índices de reprovação no primeiro ano do Ensino Médio. O mesmo também culminou na possibilidade de se desenvolver um plano de operações, cuja intenção é sanar as dificuldades dos educandos, logo no início do ano letivo.
TO THE STORY OF OLEXANDER MURASHKO’S PAINTING «AT THE OLD POND»
Authors: Dobriian Daria
Published: November 2020

This article describes the history of Oleksandr Murashko’s «At the Old Pond» painting; its creation and the following fate. It’s known that it was painted in the summer of 1911, was shown at an exhibition in Moscow right away, and even before the opening of the exhibition had been bought by the Genevan collector Arthur Horwatt. After this all traces of the picture disappear. A number of unknown facts are entered into the scientific circulation.
İki Kardeş, İki Fakih: İbn Nüceym Kardeşler
Authors: ATİK Sefa
Published: November 2020

İslam Düşüncesinin dinî boyutuna ilişkin şer’i ilimler kelam, fıkıh, hadis, tefsir, tasavvuf gibi temel disiplinlerden oluşmakta olup bu ilimler içerisinde fıkıh ilmi, hem dünyevî ve hem uhrevî hayata dair düzenleme ve normlar üretmektedir. Diğer ilimlere nispetle fıkıh ilmi özellikle insan eylemlerini düzenlemekte ve bu düzenleme faaliyetini, naslar ve bu nasları yorumlayan kurucu imamların çıkarımları, bu çıkarımlarda kullanılan yöntemleri göz önünde tutarak geçekleştirmektedir. Bir muamele ilmi olan fıkıh, düzenleme fonksiyonu ile diğer ilimlerden ayrılmakta insan ve toplum hayatına ilişkin hem teorik ve pratik çözümler üretmekte ve bu yönü itibariyle sürekli devinim içerisinde olmaktadır. Düşünce tarihi zaman, mekân ve insan gibi öğelerin katkısı ile tekevvün ettiği, geliştiği, üretildiği ve sürekli hale getirildiğine göre kurucu imamlar tarafından kaleme alınan metinler zaman içerisinde sonradan gelen ilim adamları eliyle mütemadiyen yorumlanmaya devam edecektir. Özellikle fıkıh gibi sosyal hayatın bir parçası olan ilimden bahsediyorsak bu devinime katkı sunan zaman bağlamında Memlükler, mekan bağlamında Bilâd-ı Şam, şahıs bağlamında İbn Nüceym kardeşlerin fıkıh ilmine katkıları dikkat çekmektedir. İşte bu metin, fıkıh ilmine bariz bir katkı sunan İbn Nüceym ailesi özelinde İbn Nüceym kardeşlerin Hanefî fıkhına katkısı, fıkıh anlayışları, yaşadıkları ortam, abi-kardeş ilişkininin yanında hoca-talebe ilişkisinin ilmî boyutları, aynı esere (Kenz) yapmış oldukları şerh çalışması üzerinden entelektüel ortam ve boyutu anlamayı çabalamakta ve ayrıca bu makale asıl “en-Nehr” atıflarının sahibini keşfetmeyi hedeflemektedir.
Shaking Table Tests and Numerical Analysis on the Seismic Response of Karst-Crossing Socketed Piles in Dry Sandy Soil Foundation
Authors: Wang Peisen , Ding Hongyan , Zhang Puyang
Published: November 2020

The foundation piles in karst areas have different mechanical properties from those in other areas. Targeting a critical highway bridge in a karst area, this paper designs two kinds of foundation pile models: friction pile, and KCSP, based on theories on dynamic tests. Then, shaking table tests were carried out to ascertain the features of pile strain distribution of KCSP under earthquakes. During the tests, a large laminar suspended shear box was adopted to mimic the boundary effect of soil. In addition, numerical simulations were conducted to disclose the effects of karst cave on pile strain. The test results indicate that: the peak strain of KCSP increased with the peak acceleration; For both KCSP and friction pile, the peak strain decreased first and then increased along the depth; The presence of karst cave can adversely affect the seismic response of foundation pile; The taller the karst cave, the larger the peak strain of the pile; the peak strain of KCSP was larger at the two ends, and smaller in the middle. The numerical analysis shows that: the peak strain of foundation pile in karst cave increased significantly with cave height; The peak strain of the pile passing through multiple caves was similar to that of the pile passing through only one cave, under the same cave height; But the multi-cave scenario differed from the single-cave scenario in peak strain distribution. The research results provide new insights into the seismic design of pile foundation of bridges in karst areas.
Application of Bokashi Fertilizer and Duration of Water Supply to Increase Growth, Yields, and Quality of Shallot in Dryland
Authors: Ansar Muhammad , Bahrudin  , Darman Saiful , Paiman
Published: November 2020

This study aims to improve the growth, yield, and quality of LP-VoS bulbs by applying bokashi fertilizer from goat manure and regulating the duration of water supply with a sprinkler irrigation system. This research is a field that arranged in split-plot design. The main plot is the duration of irrigation water supply, consisting of three levels, 0.5; 1,0; and 1.5 hours. The subplot is giving organic fertilizer bokashi goat manure, which consists of two kinds, namely: without bokashi fertilizer and the addition of bokashi fertilizer 15 t.ha-1. Each treatment was repeated three times so that in total, there were 18 experimental plot units. The results showed that the duration of irrigation 0.5 hours at intervals of 3 days, followed by the application of 15 t.ha-1 bokashi organic fertilizer could increase the bulb circle of 'Lembah Palu' varieties.The use of bokashi organic fertilizer 15 t.ha-1 could increase soil moisture so it can growth, yields, and quality of shallot bulb. The duration of irrigation with a sprinkler system for 0.5-1.0 hours at intervals of 3 days could result in the growth of total dry weight and total leaf area per plant as well as the number of tubers per clump, fresh weight of tubers per clump and yield of tubers per hectare higher than treatment of water for 1.5 hours at intervals of 3 days. Water supply regulations and the use of bokashi organic fertilizers can increase the growth, yield, and quality of LP-VoS bulbs on dryland. For the cultivation of‘Lembah Palu’ varieties of shallots in dry land, it is necessary to apply organic fertilizers to increase the soil water content for increased production and quality.
Complicated chronic salpingo-oophoritis in young women. Possibilities of conservative therapy
Authors: Л. В. Калугіна  , Т. І. Юско  , Е. Ф. Чайківська  , К. Д. Плаксієва  , Н. К. Сіліна
Published: November 2020

Purpose of the study: to improve the scheme of conservative treatment of chronic salpingo-oophoritis complicated by hydrosalpinx in young women.Materials and methods. The study included 65 patients with chronic salpingo-oophoritis complicated by hydrosalpinx. The mean age of patients was 28 ± 5.9 years. Women were randomized into 2 groups depending on the therapy scheme. Group I (33 women) in addition to the standard complex were prescribed Distreptaza® suppositories rectally for a period of 15 days. Group II (32 women) received a standard complex, which included an antibacterial drug and a symbiotic. The diagnostic complex carried out in the treatment dynamics included a general clinical, gynecological examination, microbiological studies. Ultrasound and determination of luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol and progesterone in plasma were performed before therapy and 1 month after.Results. Faster regression of pain in patients receiving treatment with Distreptaza® was accompanied by no sonographic signs of distal occlusion in fallopian tube in 48.48% patients; standard therapy was effective in 21.87% women. Microbiocenosis of the genital tract was restored in most patients of the examined groups after a month of treatment. There was a significant (p <0.05) 3-fold increase in progesterone levels in the second phase of the menstrual cycle after the end of antibacterial therapy in the first group. This is indicated the resumption of ovulatory cycles. This is makes it appropriate to use the selected drugs combination in young patients (up to 35 years) with unrealized reproductive plans.Conclusions. Treatment of chronic salpingo-oophoritis complicated by hydrosalpinx in young women should be comprehensive and include in the first stage empirical antibacterial, anti-inflammatory and antifungal therapy, symbiotics and polyenzyme drugs. Organ-preserving methods should be preferred among surgical methods№ 4
The systemic-praxeological approach to the methodology of primary scientific activity of the management science system
Authors: Witczak Hubert
Published: November 2020

The scientific methodology of management science (MSc) is consistent in terms of direction with the overall methodology of sciences. Still, it continues to pose significant challenges. One such challenge is the problem of system characteristics of MSc methodology at the highest level of scientific practice, i.e. praxeology and systems theory. There are also the problems of MSc synthesis, i.e. the definition of its universal scope, in the light of its increasing diversity and specialisation of doma-ins. This paper aims to elaborate on the achievements to date in management science on the grounds of the systemic-pra-xeological approach, scientific synthesis of methodology, with a particular focus on the role of reasoning and inference. My assertion is that methodology is a subsystem of the core of primary scientific activity of MSc, comprising the com-ponents of scientific practice focused around the scientific method (methods). Its objective domain extends beyond the cognitive function (C), also encompassing value assignment (A), determination of post-diagnosis scientific action (R), deci-sions about scientific models (N) and implementation of scientific models (I) –CARNI system. The scientific methodology of MSc is specifically a product of scientific problems as well as the goals, principles and methods used to solve them, for-ming an exceedingly complex system. Scientific reasoning and inference are not stand-alone scientific methods – they are ingredients of every scientific method. What sets the scientific method apart is the capability of a given scientific manner to solve a given scientific problem.
O direito fundamental a tratamento não discriminatório como limite para a extinção do contrato de emprego da pessoa com doença geradora de estigma ou preconceito
Authors: Machado André Luiz Sienkievicz , Gomes Ana Virginia Moreira
Published: November 2020

Com desenvolvimento orientado pela perspectiva teórica do direito fundamental de receber tratamento não discriminatório, o presente artigo assume o objetivo de avaliar a justiça de decisão do Tribunal Superior do Trabalho que reconheceu a presunção de prática de ato de discriminação na iniciativa do empregador de promover a extinção do contrato de emprego de trabalhadora acometida por tuberculose, considerada, pela decisão, como doença grave suscitadora de estigma ou preconceito. Para alcançar o objetivo proposto, adota como método a análise crítica dos argumentos de interpretação desenvolvidos ao longo do processo de tomada de decisão. Em seguida, confronta o conjunto de argumentos de interpretação com os três critérios de avaliação propostos pela teoria da argumentação de Neil MacCormick: consistência (ausência de contradição), coerência (acomodação sistêmica) e universalidade (possibilidade de replicação). Na sequência, sob a perspectiva teórica que orientou a realização da investigação, conclui-se pela justiça de decisão em razão da verificação da presença daqueles três elementos de avaliação.
Cuidado e direitos fundamentais: o caso do habeas corpus coletivo para pais e responsáveis por crianças e pessoas com deficiência
Authors: Vieira Regina Stela Corrêa , Tramontina Robison , Angotti Bruna
Published: November 2020

No presente estudo de caso analisamos o Habeas Corpus 165.704 DF, voltado a todas as pessoas em situação de prisão e que têm sob sua única responsabilidade deficientes e crianças. A concessão da ordem foi proferida pela Segunda Turma do Supremo Tribunal Federal (STF) em 20 de outubro de 2020, ampliando o entendimento da decisão do Habeas Corpus 143.641 SP que concedeu a substituição da prisão preventiva por domiciliar em favor de todas as mulheres submetidas à prisão cautelar, que fossem gestantes, puérperas ou mães com crianças de até 12 anos de idade e de pessoas com deficiência, salvo algumas exceções. Este caso merece ser estudado justamente por alargar o entendimento de que não apenas mães são responsáveis pelo cuidado de seus filhos, reconhecendo outras pessoas como cuidadoras principais, portanto, rompendo com a tradicional divisão sexual do trabalho. Tal discussão, urgente e necessária, deve também ser aprofundada em outras áreas, adquire especial relevância em tempos da pandemia da Covid-19, nos quais foram exacerbadas as tarefas do cuidado.
Ethnobotanical Study of Plants Used For The Wedding Ceremony in The Boyolangu Subdistrict, Tulungagung District, East Java Province
Authors: Nursita Dwi Candra , Amalia Denis , Minarno Eko Budi
Published: November 2020

Javanese ethnic still upholds local wisdom including marriage customs. Traditional wedding ceremonies inherited from ancestors are still practiced up to present in the Boyolangu subdistrict, Tulungagung District, East Java Province. Traditional wedding ceremonies in this area are often carried out by utilizing plants during the procession, especially at the procession of temu manten. The use of plants in this procession is closely related to ethnobotany. Ethnobotany is an ecological discipline and the principle of the community's conception of local plants sources that can be used as a protector of cultural values. This research aims to find out the types of plants that are used as in the traditional wedding ceremonies and to provide an understanding of conservation of certain plants typically used for traditional wedding ceremonies. This research used quantitative descriptive design and applied a purposive sampling technique. It involved 10 respondents of community and 1 key informant (dukun manten or shaman). Based on the results of the study, the community in this area uses a total of 14 species of plants of 11 families at a traditional wedding ceremony. Commonly, the community utilizes the leaves and other parts of plants such as fruit, seeds, stems, and flowers. They are directly arranged in a certain way and used. The plants are obtained from around the yards of the community’s house
A review on biological activities of Schiff base ligand and
their metal complexes
Authors: Jadhav P.M.
Published: November 2020

Schiff bases and their metal complexes are wide range of biological applications
and are synthesized from the condensation reaction of amino compounds with carbonyl
compounds. Schiff base and their metal complexes have a wide variety of applications in food
and dye industry, agrochemical, polymer, catalysis, analytical chemistry, antifertility, antiinflammatory activity, antiradical activity, and biological system as enzymatic agents. Several
have reviewed them of their antimicrobial, antibacterial, antifungal, antitumor, and cytotoxic
activities. This review summarized the most promising biological activities of Schiff bases and
their metal complexes
Endophytic Streptomyces sp. LRE541 isolated from Lilium davidii var. Unicolor Cotton as a Cell Factory for Antimicrobials and Anticarcinogens with Inducing Apoptosis and Cell Cycle Arrest Properties
Authors: Ma Aiai , Qi Xinge , Jiang Kan , Chen Bin , Liu Junlin , Zhao Changming
Published: November 2020

Background: Endophytic actinomycetes, as emerging sources of bioactive metabolites, play a vital role in pharmaceutical development. Recent reports demonstrated that endophytic Streptomyces isolates could yield compounds with potent anticancer and antimicrobial properties that may be developed into chemotherapeutic drugs. Our study displayed that Streptomyces sp. LRE541 obtained from the root tissues of Lilium davidii var. unicolor Cotton, could be a potential source of anticarcinogens and antimicrobials.Results: Isolate LRE541 was characterized and identified as belonging to the genus Streptomyces based on the 16S rDNA sequence analysis, with highest sequence similarity to Streptomyces tauricus JCM4837T (98.81%). It produced extensively branched red substrate and vivid pink aerial hyphae that changed into amaranth, with elliptic spores sessile to the aerial mycelia. The secondary metabolites (EtOAc extract) produced by isolate LRE541 exhibited significant anticancer activities with IC50 values of 0.021, 0.2904, 1.484, 4.861, 6.986, 8.106, 10.87, 12.98, and 16.94 μg/mL against cancer cells RKO, 7901, HepG2, CAL-27, MCF-7, K562, Hela, SW1190 and A549, respectively, evaluated by the MTT assay. In contrast, the EtOAc extract showed less cytotoxicity activity against the normal human pulmonary artery endothelial cell (HPAEC) with an IC50 value of > 20 μg/mL than that of the cancer cells. To further explore the mechanism underlying the decrease in viability of cancer cells following the EtOAc extract treatment, cell apoptosis and cell cycle arrest assays were performed using two cancer cell lines, RKO and 7901. The result demonstrated that the EtOAc extract inhibited cell proliferation of RKO and 7901 cells by causing cell cycle arrest both at the S phase and inducing apoptosis in a dose‑dependent manner. Moreover, the EtOAc extract of isolate LRE541 with the concentrations within 100 μg/mL also possessed the antagonistic activities against E. coli ATCC 25922, MRSA ATCC 25923, P. aeruginosa and C. albicans ATCC 66415, and the antagonistic potent against the tested pathogens all displayed a dose-dependent manner. The UHPLC-MS/MS analysis of the EtOAc extract revealed that the presence of antitumor, potential antitumor and antimicrobial compounds could account for the potent antineoplasmic and antagonistic properties of the extract. Conclusion: This study provides the potential therapeutic applications of the bioactive metabolites from Streptomyces sp. LRE541 as novel antimicrobial and anticancer agents.
Prevalence and Determinants of Fertility Desire Among HIV-positive Women in Rwanda in the Context of Improved Life Expectancy: A Statistical Analysis of Cross-Sectional Data
Authors: Niragire François , Ndikumana Celestin , Nyirahabimana Marie Gaudence , Uwizeye Dieudonne
Published: November 2020

Background: The knowledge of the key determinants of fertility desire among people living with HIV/AIDS is crucial for the design of efficient maternal and child health care programs. However, such determinants are not well understood in the context of a successful scale-up of antiretroviral therapy in Rwanda. The present study aim was to assess fertility desire among HIV- positive women and its determinants in Rwanda.Methods: Data were extracted from the 2015 Rwanda demographic health survey (RDHS) for 243 HIV-positive women of reproductive age. Univariate and multivariable based variable selection as well as multivariable logistic regression analysis were conducted. Results: The prevalence of desire to have another child in HIV-positive women was as high as 40.7%. Multivariable logistic regression analyses showed that the woman’s age, number of her living children, woman’s employment status, and having a co-wife are significant determinants of fertility desire among HIV- positive women in Rwanda. Women younger than 25 years, with no living child, who were unemployed or who had at least a co-wife were associated with greater odds of desire to have another child in the future than other HIV- positive women.. Conclusion: There is a need to devise integrated programs and services that are tailored to support HIV-positive women in planning their fertility, and controlling HIV transmission to their prospective children. Efficient policy and fertility interventions among WLHA in Rwanda should target young women, especially those living with partners and have fewer children than they prefer.
Enhanced Mechanical Property of RMI C/SiC Composites with Optimized Porous Carbon Structure by Heat Treatment
Authors: Guo Ruru , Li Zhijian , Li Lu , Wang Peng , Ma Chaoli
Published: November 2020

C/SiC composites were fabricated by reactive melt infiltration (RMI) using porous C/C preforms as the skeleton, followed by the infiltration of molten silicon. A convenient technique of heat treatment in the range of 1500 to 2400 oC was applied to modify the porous carbon structure. The effects of heat treatment on the porous C/C preforms and the as-synthesized C/SiC composites were investigated in detail. The results show that the optimal porous carbon structure could be obtained after heat treatment at 1500 oC. After 1500 oC heat treatment, the median pore size and porosity of the porous C/C preform were 9.3 µm and 13.65% respectively, which were in favor of the subsequent infiltration of molten Si. The C/SiC composites with the optimized porous carbon structure showed a dense and uniform morphology without obvious cracks. Their bending strength could be up to 276 MPa, which was 28% higher than that of the C/SiC composites with untreated C/C preforms. However, with the increasing heat treatment temperature (2400 oC), the bending strength of the as obtained composites began to decrease because of the degradation of in-situ fiber strength. The optimized C/SiC composites exhibited a typical pseudo-plastic fracture behavior with obvious fiber pull-out. The improved mechanical property could be ascribed to the lower porosity of composites, the higher in-situ strength of fibers and the reduced matrix cracks.
Yttrium Doped TiO2 Thin Film for Gas Sensing Application Prepared by Spin Coating Method
Authors: Kaiyum M Abdul , Ahmed Naim , Alam Arif , Rahman M Shamimur
Published: November 2020

Yttrium (Y) doped and pure Titanium Di-oxide (TiO2) thin films were prepared by using spin coater. The coater was set up in laboratory with low cost investment. The films were calcined at 450 °C for 1 hour. For characterization, Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Analysis (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Atomic Force Microscopy (AFM) were carried out. LCR Bridge - GW Instek LCR-821 was used for gas sensing applications. XPS showed that the change of electronic structure due to Y doping. SEM and AFM analysis were carried out to determine the surface morphology of the films. Yttrium (Y) decreased the crystallite size of the films and increased the surface roughness and porosity value, which was very good for many sensing applications. Gas sensing property of the deposited films were improved by the incorporation of yttrium impurities and the sensing property improved almost two times than pure TiO2 thin film. Different researches have been done their research related to this topic but no one researchers provide a precise explanation of their results, authors of this research have tried to do that. Moreover the films were prepared by a simple spin coater to reduce the production cost also.
Investigation of the Therapeutic Potential of Momelotinib on Hepatitis Virus-Associated Liver Cancer Is Through Suppressing Oncogenic/Stemnes IFNGR-JAK-STAT Pathway
Authors: Ong Jiann Ruey , Yeh Chi-Tai , Huang Ting-Yi , Hsieh Ming-Shou , Lee Wei-Hwa , Cherng Yih-Giun
Published: November 2020

The authors have requested that this preprint be removed from Research Square.