bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PEMIDANAAN PERBUATAN MERINTANGI AKTIVITAS PERTAMBANGAN MINERAL DAN BATUBARA PERSPEKTIF UNITED NATION GUIDING PRINCIPLES ON BUSINESS AND HUMAN RIGHTS DAN UUD 1945
Authors: Siti Maemunah
Published: August 2024

Ratification of Law no. 3 of 2020 became the new Minerba Law and the implementation of Article 162 of the Minerba Law contained there in triggered conflicts that occurred in society. Article 162 of the Mining and Coal Law is referred to as the "Penalty Article" and the "Rubber Article", this is because the substance contained therein contains criminal offenses for anyone who "obstructs" or "disrupts" mining activities. Punishment here is related to criminal acts, where criminal acts are actions that violate laws, statutes, norms and values that apply in society.
The results show that the punishment for obstructing mineral and coal mining activities in Indonesia has violated the human rights of communities that refuse mining. The government is considered to have abused the people living in the area around the mining area. In the perspective of the UNGPs-BHR, the criminal act of obstructing mineral and coal mining activities is said to not fulfill the elements contained in the UNGPs-BHR.
THE ROLE OF GENDER STUDIES CENTER AND CHILD (PSGA) IAIN SALATIGA IN PREVENTING SEXUAL VIOLENCE PERSPECTIVE OF MAQASID SYARIAH
Authors: Nastangin  , Aji Saputro
Published: August 2024

Sexual violence and harassment is a very inhumane act. This is a violation of both religious and state regulations. Nowadays, there are so many cases of sexual violence committed by perpetrators. Cases of sexual violence can take various forms of women, for example rape. In fact, this case does not only happen to adult women but also to children who are still underage. In essence, woman is a noble figure who must be protected. Therefore, the researcher has two questions related to this research, that : What steps does the PSGA take in preventing sexual violence and what is the role of PSGA in preventing sexual violence perspective of Maqasid Sharia. This research uses a type of qualitative research, namely research that aims to understand phenomena about what is experienced by research subjects, for example behavior, perceptions, motivations, actions, etc., holistically, and in a descriptive way in form of words and language, in a special natural context and by utilizing various natural methods. The results of this research are first steps of PSGA in preventing sexual violence, that: socialization, holding training, conducting counseling, having campus regulations, preparing guidelines related to sexual violence, making SOP (Standard operating procedure) and forming student agents. These are the steps that have been taken by PSGA to prevent sexual violence. Second, role of PSGA in preventing sexual violence has been carried out well through: As the leading sector (driving force) for violence prevention at IAIN Salatiga, as the person responsible for socializing prevention of sexual violence and drafting regulations of Chancellor regarding prevention and handling of sexual violence. These roles, when viewed from the perspective of Maqasid Sharia, basically have same goal as one of the goals of Maqasid Sharia that to protect the soul and descendant. Because if sexual violence does not occur, lives and descendant can be protected, which is what the PSGA actually hopes for.
Dinámicas y comportamientos de las empresas innovadoras del sector manufacturero colombiano
Authors: Sepúlveda-Rivillas Claudia Inés , Restrepo-Ramírez Carlos Gilberto , Vélez-Jaramillo Juan Daniel
Published: August 2024

La innovación se ha convertido en una estrategia organizacional que contribuye al logro de objetivos, como la supervivencia y el crecimiento. La literatura ha identificado que las organizaciones adoptan sus propias formas de innovación, desarrollando diferentes comportamientos y actitudes hacia la innovación que son determinantes en los resultados que obtienen. Sin embargo, en países emergentes como Colombia se requiere mayor evidencia empírica con respecto a las diferencias que existen entre orientaciones estratégicas con un enfoque interno y externo. Por lo tanto, el objetivo de este artículo es identificar las diferencias en las características y comportamientos de innovación determinantes para los resultados de innovación de las empresas manufactureras colombianas. Para tal fin, se utilizó información de fuente secundaria obtenida a partir de la Encuesta de Desarrollo e Innovación Tecnológica (EDIT), y se adoptó una metodología cuantitativa, utilizando las técnicas de clúster jerárquico y tablas de contingencia, que permitió identificar tres grupos de empresas en el sector manufacturero colombiano: empresas con alto nivel de actividades en ciencia, tecnología e innovación, y que obtienen los mejores resultados de innovación; empresas que alcanzan altos resultados de innovación mediante imitación y empresas que no realizan actividades de ciencia, tecnología e innovación. Esta investigación contribuye al desarrollo de la teoría acerca de orientación estratégica a la innovación, especialmente en el sector manufacturero, que se ha caracterizado por ser uno de los más innovadores según sus registros de propiedad intelectual. Además, la investigación presenta contribuciones prácticas para los tomadores de decisiones en las organizaciones, dado que describe los comportamientos que están asociados a un grupo de empresas que obtienen los mejores resultados de innovación.
Impacto de los programas de transferencias monetarias sobre el mercado laboral y la pobreza en Colombia, 2013-2020
Authors: Sotelo Forero Lorena , Vallejo Zamudio Luis E.
Published: August 2024

Los programas de transferencias monetarias (PTM) se han convertido en una de las estrategias más populares de la política social en la lucha contra la pobreza en los países en desarrollo. Estos programas han demostrado tener efectos positivos sobre la pobreza; sin embargo, también generan preocupación por sus posibles consecuencias sobre el mercado laboral. En este sentido, el objetivo de este artículo es realizar una caracterización de la evolución de los programas de transferencias frente a las variables de pobreza monetaria y extrema, y las variables del mercado laboral como participación e informalidad. Adicional, se realiza la estimación del efecto que ha tenido Familias en Acción sobre estas variables, utilizando la metodología de diferencias en diferencias para datos trasversales repetidos y la metodología compuesta de Propensity Score Matching con diferencias en diferencias. Los resultados indican que los PTM han contribuido de manera moderada en la disminución de la pobreza y no tienen mayores efectos sobre el mercado laboral. No obstante, su efecto ha estado más relacionado con el alivio transitorio de la pobreza que con su reducción intergeneracional a largo plazo.
Advanced Applications of Artificial Intelligence in Pharmacovigilance: Current Trends and Future Perspectives
Authors:   Department of Pharmacology, KBHSS Trust’s Institute of Pharmacy, Malegaon, Nashik, Maharashtra, India, Ahire Yogesh S , Patil Jayesh H , Chordiya Harshita N , Deore Rashmi A , Bairagi Vinod A
Published: August 2024

The primary goal of pharmacovigilance, the cornerstone of public health, is to track and evaluate adverse drug reactions in order to guarantee patient safety. Conventional approaches suffer from biases in human error, inefficiency, and scalability problems. A new era in pharmacovigilance is being ushered in by the introduction of artificial intelligence (AI), which holds the promise of vast data analysis, automated procedures, and enhanced safety signal detection. Artificial intelligence technologies improve adverse event detection and signal identification by providing unparalleled speed, accuracy, and scalability. They are adept at applying sophisticated algorithms, machine learning models, and natural language processing to glean insights from unstructured data sources like clinical notes, patient narratives, and regulatory reports. This capacity makes it possible to implement risk management plans that are more thorough and proactive. However, using artificial intelligence in pharmacovigilance necessitates large expenditures for processing power, infrastructure, and regulatory compliance. For artificial intelligence-driven systems to be accurate, dependable, and applicable, ongoing validation, monitoring, and improvement efforts are essential. The ethical and legal implications of patient privacy, data security, and regulatory compliance underscore the necessity of cautious artificial intelligence deployment in order to maintain public trust and protect patient rights. Regulatory agencies, healthcare professionals, and artificial intelligence developers must work together efficiently to implement explainable artificial intelligence frameworks, adaptive surveillance techniques, and improved signal validation processes in order to fully realize the potential of artificial intelligence in pharmacovigilance. This will usher in a new era of proactive risk assessment and improved public health outcomes. Keywords Pharmacovigilance, Artificial Intelligence, Signal Detection, Regulatory Affairs, Patient Safety, Public Health
Antibacterial Efficacy of Eucalyptus Essential Oil against Respiratory Infection Pathogens and Characterization of its Bioactive Compounds
Authors:   Department of Microbiology, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria, Abiodun Ajijolakewu  Kamoldeen , Nike Ahmed Risikat , Olanike Kazeem Muinat , Olakunle Otuyelu Frank , Mojisola Abdulraheem Zulaikhat
Published: August 2024

Antibacterial activity of eucalyptus essential oils (EEO) against some respiratory pathogens and its mechanism of action were studied. Clinical pathogens used in the study were Enterobacter cloacae, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. Disk diffusion, macro and microbroth dilution methods were respectively used to assess antibacterial assay, minimum inhibitory concentration (MIC) and growth inhibition assay using standard antibiotics as references. Gas chromatography Mass spectrometry was used to characterize the bioactive compounds present in EEO. Scanning electron microscopy was used to determine the mode of action of EEO on test pathogens. A total of 12 compounds were found to have bioactive functions with p-Cymene having 34.07%, gamma-Terpinene (7.01%), Cyclohexasiloxane (5.30%), 2-Aminobenzoic acid (4.59%). The EEO exerts varying antibacterial effects on susceptible organisms. At 100 mg/ml concentration the EEO antibacterial activities were observed on E. cloacae with 23.0 mm mean zone of inhibition, K. pneumoniae (22.7 mm) and S. aureus (16.0 mm) while no activity was recorded on P. aeruginosa. The MIC and MBC of the EEO on susceptible organisms were E. cloacae (6.25mg/ml, 12.5mg/ml); S. aureus (25mg/ml. 50mg/ml) respectively, while both MIC and MBC of EEO on K. pneumoniae was 50mg/ml. Scanning electron microscopy displayed noticeable damages of cell morphology and ultrastructure on two most susceptible pathogens (E. cloacae and K. pneumoniae), thus increase cell permeability and subsequent cell death. This study showed EEO is a potent antibacterials against some respiratory pathogens and can be further explored in treating respiratory and other infections caused by these pathogens. The positive effect of eucalyptus essential oil on the selected respiratory infection pathogens could make it an important part of drug (ointment formation) for the treatment of such infections. Keywords Essential Oils, Bioactive Compounds, Respiratory Pathogens, Susceptibility, GCMS
A Influência da Educação Musical no Desenvolvimento Cognitivo Infantil
Authors: Machado Alonso de Araújo Maria Clara , Campello de Freitas Saulo Henrique , Raposo de Lima Lívia Milena , Barros Gonçalves da Silva Caio Victor , Serafim da Silva Lopes Isvania Maria , Marques Coutinho Mateus , Souza Alves da Silva Ingrid Thayanne , Dos Santos Souza Baracho Ester Fernanda
Published: August 2024

Este artigo tem como objetivo identificar a influência da educação musical no desenvolvimento cognitivo ocorrido na primeira infância, destacando as conexões entre música e neurociência, bem como seus benefícios na autorregulação e nos aspectos emocionais encontrados em crianças. Estudos demonstram que a exposição precoce à música modula a neuroplasticidade sináptica, influenciando o aprendizado e o desenvolvimento cerebral. Uma revisão sistemática foi elaborada a partir de estudos que identificavam graus de influências ocorridas no desenvolvimento cognitivo infantil a partir da exposição à educação musical. Foram utilizados os descritores obtidos no Descritores em Ciências da Saúde (DeCS/MeSH) “Cognição”, “Infância”, “Música”, “Desenvolvimento cognitivo”, e “Educação musical” após a aplicação dos critérios de inclusão e exclusão, foram selecionados 12 trabalhos científicos para a realização da revisão. Concluiu-se que a prática da educação musical é uma abordagem bem-sucedida e benéfica, que afeta áreas cerebrais relacionadas ao processamento cognitivo, sensorial-motor e socioemocional, promovendo o desenvolvimento de habilidades como linguagem, raciocínio espacial, inteligência emocional e social.
ANÁLOGOS DE GLP-1 NA DOENÇA DE PARKINSON: UMA REVISÃO
Authors: Maciel Laís Macêdo , Falcão de Moraes João Gabriel , Mendonça Ingrid Prata , Gonçalves da Silva Caio Victor Barros , Barbosa de Araújo Karolliny , Rodrigues de Paiva Igor Henrique , Kosminsky Ellen , Tenorio Cavalcanti Camilla de Andrade , Arruda da Rocha Maria Lavinya , Serafim da Silva Lopes Isvânia Maria
Published: August 2024

A Doença de Parkinson (DP) é um distúrbio neurodegenerativo que afeta a mobilidade e a função cognitiva, com origem na perda de neurônios produtores de dopamina. A compreensão da DP e o desenvolvimento de novas terapias são desafiadores devido à complexidade dos mecanismos neuronais envolvidos. O objetivo desta revisão foi investigar a eficácia dos análogos de GLP-1 como tratamento potencial para a DP, explorando seus efeitos neuroprotetores e a capacidade de melhorar os sintomas motores e não motores. Foi realizada uma revisão sistemática nas bases de dados PubMed, Scopus, Lilacs e Web of Science, utilizando os descritores “Parkinson's Disease” e “GLP 1 Receptor”. Foram selecionados estudos que abordaram o uso de análogos de GLP-1 em modelos pré-clínicos e clínicos de DP. Os resultados mostraram que, os análogos de GLP-1 possuem propriedades antioxidantes, anti-inflamatórias e neuroprotetoras em modelos de DP, sugerindo um potencial terapêutico. Estudos clínicos preliminares indicam melhora nos sintomas da DP, mas são necessários mais ensaios clínicos randomizados para confirmar esses resultados. Portanto, os análogos de GLP-1 emergem como uma promissora classe de fármacos para o tratamento da DP, com a possibilidade de oferecer benefícios além do controle glicêmico, incluindo neuroproteção e melhora dos sintomas motores e não motores.
A N-ACETILCISTEÍNA NA REDUÇÃO DA BUSCA POR NICOTINA EM HUMANOS E ROEDORES: UMA REVISÃO SISTEMÁTICA
Authors: Souza Alves da Silva Ingrid Thayanne , De Andrade Tenorio Cavalcanti Camilla , Souza Ferreira Amanda Gabriela , Marques Coutinho Mateus , Machado Alonso de Araújo Maria Clara , Thorpe Nunes Mendonça Pedro Gabriell , Dos Santos Souza Baracho Ester Fernanda , Barros Gonçalves da Silva Caio Victor , Henrique Campello de Freitas Saulo , Raposo de Lima Lívia Milena , Serafim da Silva Lopes Isvânia Maria
Published: August 2024

INTRODUÇÃO: A nicotina reforça o comportamento de fumar, provocando efeitos que fomentam acentuada morbidade ao longo da vida. A N-acetilcisteína é um derivado sintético do aminoácido L-cisteína, que caracteriza uma nova abordagem farmacoterapêutica para atenuar o desejo e a recaída, entretanto, ainda não há um consenso acerca da eficácia da NAC na redução da busca por nicotina. OBJETIVO: O presente estudo visa identificar e reunir evidências recentes sobre os efeitos da N-acetilcisteína na redução da busca por nicotina em humanos e roedores. MÉTODOS: Foi realizada uma revisão sistemática da literatura acerca da associação entre a N-Acetilcisteína e a redução da busca por nicotina em humanos e roedores. Foram utilizados os descritores “N-Acetylcysteine”, “Nicotine” e “Seeking Behavior”, mediante o operador booleano “AND” . Após a aplicação dos critérios de inclusão e exclusão foram selecionados sete artigos, para a realização do estudo. RESULTADOS:  Os estudos incluídos em modelos animais demonstram que o NAC pode ter efeitos positivos, dependentes de fatores como duração do tratamento, na redução do comportamento de busca por nicotina; outros estudos clínicos não conseguiram demonstrar benefícios significativos na redução da busca por nicotina em fumantes humanos. CONCLUSÃO: A eficácia do NAC parece depender da duração do tratamento e das doses administradas em ratos e humanos e, também, da combinação com terapias comportamentais em humanos.
O PAPEL DAS GALECTINAS NA INFLAMAÇÃO E MIELINIZAÇÃO EM DISFUNÇÕES COGNITIVAS DE DISTÚRBIOS NEUROLÓGICOS
Authors: Cavalcante Muniz Gomes Celina , Germano Crispim Joelson , Gabriel Menezes Bezerra Ykaro , Sibelly Pereira de Lima Viviane , Melgarejo da Rosa Michelle
Published: August 2024

Distúrbios neurológicos (DNs) têm crescido junto ao envelhecimento e aumento populacional global, sendo um desafio ao sistema de saúde pública. DNs envolvem disfunções sinápticas e moleculares que comprometem a cognição, memória e aprendizado. As galectinas (gal) são potenciais moduladoras da neuroinflamação, com expressão neurológica. Assim, tem-se como objetivo entender a associação entre as galectinas, vias moleculares e celulares na fisiopatologia de DNs. Realizou-se uma revisão narrativa nas bases de dados Pubmed, LILACS e Scielo, com as palavras-chave em inglês e português “galectins” and “cognition”. 23 estudos in vivo, in vitro e post-mortem foram incluídos nesta revisão. Na Doença de Alzheimer (DA), isquemia/reperfusão renal (IR), HIV, malária cerebral e esquizofrenia, diversos estudos mostraram relação entre expressão significativa aumentada ou reduzida da gal-3, gal-9, gal-8 e gal-1 e marcadores pró-inflamatórios e anti-inflamatórios, neurodegenerativos e sinápticos. Na DA, apneia obstrutiva do sono e IR, o silenciamento ou inibição farmacológica da gal-3 atenuou a neuroinflamação e apoptose neuronal, gerou proteção contra neurotoxicidade e melhorou o comprometimento cognitivo. Na isquemia a administração de gal-3 gerou remielinização e atenuação de déficits cognitivos. Concluiu-se que as galectinas –1, –3, -4, -8 e –9 modulam processos neuroinflamatórios e neurodegenerativos presentes em disfunções cognitivas de DNs, sendo potenciais alvos terapêuticos.  
Palavras-chave: galectinas; cognição; neurofisiologia; inflamação; mielina.
Insufficient Diagnostic Value of Serum Galactomannan and (1,3)-β-D-Glucan in Paranasal Sinus Fungus Balls
Authors: Chang Suk Won , Jeong Yeonsu , Kang Ju Wan , Kim Chang-Hoon , Cho Hyung-Ju
Published: August 2024

Background and Objectives: The serum galactomannan test (GM test) and the (1,3)-β-D-glucan test (G test) are utilized in diagnosing invasive fungal sinusitis. However, their effectiveness in detecting paranasal sinus fungus balls (FBs) has not been established. This study aimed to explore their diagnostic value in patients with FBs.Methods: We retrospectively reviewed the medical records of 105 patients (42 with FBs and 63 with chronic rhinosinusitis [CRS]) who underwent serum GM and G tests between June 2020 and May 2021. Olfactory test results and demographics were also analyzed.Results: There were 42 FB patients (10 men, 32 women) and 63 CRS patients (27 men, 36 women). The positivity rates for serum GM (7.1% in the FB group vs. 3.2% in the CRS group, p=0.640) and G test (9.5% in the FB group vs. 11.1% in the CRS group, p=0.482) did not differ significantly between groups. The sensitivities of the GM and G tests were 7.1% and 9.5%, respectively, and their specificities were 96.8% and 88.9%, respectively. The positive predictive values were 60.0% for the GM test and 36.3% for the G test, and the negative predictive values were 61.0% for the GM test and 59.6% for the G test.Conclusion: Serum GM and G tests demonstrated low sensitivity and high specificity, indicating limited effectiveness in differentiating between patients with FBs and those with CRS. Histological examination remains the gold standard for the definitive diagnosis of FBs.
Particulate Matter Induces NLRP3 Inflammasome-Mediated Pyroptosis in Human Nasal Epithelial Cells
Authors: Choi Hosung , Choi Hyunsu , Oh Jeong-Min , Lee Dong Chang
Published: August 2024

Background and Objectives: Air pollution, particularly particulate matter (PM), has a variety of adverse effects on human health. PM is known to induce cell death through various pathways, including pyroptosis. Despite its significance, research on PM-induced pyroptosis in nasal epithelial cells remains limited. This study aimed to explore PM-induced pyroptosis in cultured human nasal epithelial cells.Methods: For the in vitro experiments, human nasal epithelial cells were cultured. Cell viability was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while cell death was evaluated through propidium iodide (PI) staining and lactate dehydrogenase (LDH) release measurement. Protein expression levels related to pyroptosis were examined via western blot using antibodies against NOD-like receptor family, pyrin domain containing 3 (NLRP3), cleaved caspase-1 (CASP1 P20), gasdermin D (GSDMD)-N, and glyceraldehyde phosphate dehydrogenase. Immunofluorescent staining with a CASP1 P20 antibody was conducted to visualize cellular localization. Enzyme-linked immunosorbent assay was utilized to quantify interleukin (IL)-1β and IL-18 protein levels.Results: Treatment with PM resulted in decreased cell viability, elevated LDH release, and intensified PI staining, indicating cell death. Pyroptosis was confirmed by the elevated expression of NLRP3, CASP1 P20, and GSDMD-N, along with increased levels of IL-1β and IL-18. Inhibiting the NLRP3 inflammasome with MCC950 reduced the PM-induced effects on protein expression and cytokine release, highlighting the role of the NLRP3 inflammasome in PM-triggered pyroptosis in human nasal epithelial cells.Conclusion: We showed that PM triggers pyroptosis in human nasal epithelial cells, driven by NLRP3 inflammasome-dependent signaling pathways.
Reproductive health protection: medical and organizational measures and legal regulation
Authors: Selikhova Marina S. , Voroshilova Svetlana V. , Soltys Polina A. , Moon Victoria A.
Published: August 2024

. The article presents an analysis of medical-organizational and state-legal factors affecting the reproductive health of the population. The state is interested in maintaining natural population growth. Changes in legislation in the field of reproductive rights are considered in order to provide effective legal guarantees for the implementation of the right to use reproductive technologies. The legal framework has been defined, as well as a set of therapeutic and preventive measures aimed at improving the reproductive health of the population. The state-legal protection of the reproductive health of citizens, the inclusion of reproductive rights in strategic planning documents indicate that reproductive health is considered an important factor in the development of the country.
Epidemiology of allelic gene variants of hereditary thrombophilic condition in the population of the Arkhangelsk region
Authors: Vorontsova Alexandra S. , Vorobyova Nadezhda A. , Vorobyova Alyona I. , Melnichuk Elizaveta Yu.
Published: August 2024

Single-nucleatide substitutions in genes encoding proteins of the hemostasis system and platelet receptors are one of the causes of hereditary predisposition to hypercoagulation and increased thrombosis. The aim is to assess the prevalence of individual allelic variants of hemostasis genes in the population of the Arkhangelsk region. Materials and methods: The study included two groups of participants from the Arkhangelsk region: patients of the Regional Center for Antithrombotic Therapy (RCATT) (n = 2354) and healthy volunteers (n = 195). The molecular genetic study of the polymorphism of the genes of the hemostasis system was carried out by PCR. The results of the study: According to the results of the study, there was no statistically significant difference in the distribution of unfavorable allelic variants of \hemostasis genes between the two groups of participants. Probably, in order to realize the hereditary tendency to increased thrombosis, it is necessary to combine the polymorphism of the studied genes with other
The flowmetry and enzymatic activity of bile in biliary acute pancreatitis
Authors: Balatskii Evgeny R. , Yurenko Mikhail V. , Konovalenko Alexey V.
Published: August 2024

The article presents data on the analysis of the flow rate and the level of bile amylase in 56 patients with biliary acute pancreatitis of varying severity (according to rapid assessment) and cholecystolithiasis operated on urgent indications. Bile flow of more than 500 mL per day corresponds to mild severity (R = 4,000; CI = 0.956–10.880; p 0.05) and is rare in severe cases of the disease (R = 0.133; CI = 0.022–0.515; p 0.05). Bile flow less than 100 mL per day is characteristic only for severe course (R = 0.133; CI = 0.467–27.735; p 0.05). Differences in the level of bile alpha-amylase are statistically significant between mild and severe course of biliary acute pancreatitis (p = 0.000011) and are not significant between moderate and severe course of the disease (p = 0.146275). For severe and moderate disease, the decrease in alpha-amylase indicators occurred stepwise, with significant differences on days 2 and 5 after surgery. Indicators of bile flow rate and of alpha-amylase level can be prognostic criteria for the severity of biliary acute pancreatitis.
Morphofunctional characteristics of the liver after administration of ascorbic acid in a model of radiation hepatitis
Authors: Demyashkin Grigory A. , Yakimenko Vladislav A. , Vadyukhin Matvey A. , Kitieva Alina A. , Vasileva Natalya V.
Published: August 2024

Introduction: Radiation-induced hepatitis develops both with direct irradiation of malignant neoplasms of the liver and abdominal organs. An important task of modern radiobiology is the development of methods for the prevention of acute and chronic post-radiation complications, for example, the injections of protectors. Materials and methods: Wistar rats (n = 40) were divided into groups: I – control (n = 10); II (n = 10) – electron irradiation; III (n = 10) – injection of ascorbic acid before electron irradiation; IV (n = 10) – injection of ascorbic acid. A biochemical blood test, oxidative status analysis, morphological, morphometric and statistical studies were carried out. Results: In group III, a less pronounced change in the main morphological and morphometric parameters was noted compared to group II; indicators of biochemical analysis and oxidative status approached control values. Conclusions: According to the results of the study, it was revealed that local irradiation with electrons after a week leads to disruption of the histoarchitecture of the liver, and the injection of ascorbic acid reduces the depth and range of radiation-induced hepatitis.
Immediate and long-term results of closure of a functioning single-stem ileostomy
Authors: Zurnadzhiants Viktor A. , Kichibekov Eldar A. , Dadaev Ibrahim S.
Published: August 2024

The aim of the work was to study and evaluate the immediate and long-term results after performing reconstructive and reconstructive operations to eliminate functioning ileostomes. Materials and methods: We operated on 30 patients with functioning single-stem ileostomes in 2019–2022. All interventions were performed as planned. The average age of patients at the time of reconstructive and reconstructive operations was in the range from 35 to 72 years. There were 18 men and 12 women. Results: When using in clinical practice the method of areflux small-colonic anastomosis developed by us in the early postoperative period, intestinal paresis and seromas of the postoperative wound were observed, which were resolved by conservative measures. No complications were observed in the long-term postoperative period. Conclusions: The developed valvular, areflux small-colonic anastomosis prevents reflux of the contents of the colon into the small intestine, thereby preventing the development of SIBR and the number of postoperative complications.
Analysis of prevalence dynamics breastfeeding (according to the center for the promotion and support of breastfeeding of the Astrakhan region)
Authors: Sagitova Gulnara R. , Antonova Alyona A. , Davydova Oksana V. , Shuldais Vladimir A. , Klyueva Nonna V. , Komar Anastasia M. , Ledyaev Mikhail Ya.
Published: August 2024

Breastfeeding is the best way to provide ideal nutrition for the healthy growth and development of infants. The aim of our work was to analyze the dynamics of the prevalence of breastfeeding in the Astrakhan region. Based on the data obtained, it can be concluded that in the whole city and region, the breastfeeding rate remains consistently high – 65,8 % (in 2019 – 64,5 %). This indicates the need to continue to promote and support breastfeeding, as well as the prevention and effective treatment of hypogalactia.
Chronic venous disease of the lower extremities as a risk factor for PE when taking combined oral contraceptives: a clinical case
Authors: Tulchiy Vlada O. , Chukhareva Maria A. , Anokhin Alexey V.
Published: August 2024

The use of combined oral contraceptives (COCs) is one of the risk factors for thrombotic complications, particularly pulmonary embolism (PE). Although clinical observations suggest that the risk of thrombotic complications with OCs is low and decreases after several months of use, medical counseling is necessary as with any other hormonal therapy. A clinical case of PE in a young patient taking COCs is presented. In the context of early diagnosis, thrombolysis was successful because thrombus retraction had not yet occurred. After completion of treatment of the underlying pathology, the patient was recommended to be followed up with a vascular surgeon for treatment of lower limb venous disease. Exclusion of lower extremity venous disease is critical before prescribing COCs, as it increases the risk of PE at any age.
Intravesical methods of treatment upon overactive bladder (literature review)
Authors: Poroysky Sergey V. , Perlin Dmitry V. , Goncharov Nikolay A. , Kuznetsov Alexander A. , Morozov Egor A.
Published: August 2024

In this article we come across generalized literature data devoted to treatment of overactive bladder (OAB). We look through basic methods of OAB treatment: application of M-cholinolythics and their disadvantages, BBC-therapy, and also intravesical methods. Intravesical methods like intravesical Oxibutanine electrophoresis, Capsaicyne and Rosipheranotoxine injections are not clinically widespread. However intravesical (intradetrusal) injections of Botulotoxine type A are used in an active way with nice clinical effects, but are demanding general anaesthesia with all it’s risks. The number of clinical trials devoted to Botulotoxine A intravesical usage via instillations is limited, thus demanding additional researches.
Background of use in real clinical practice of the results of a systematic review and meta-analysis by comparison vacuum-assisted laparostomy and other options of multi-stage surgical treatment of urgent abdominal pathology and abdominal injuries
Authors: Maskin Sergey S. , Alexandrov Vasily V. , Derbentseva Tatyana V. , Matyukhin Viktor V. , Rashid Azad , Sigaev Sergey M. , Biryulev Dmitry S.
Published: August 2024

Background: Multi-stage surgical treatment of patients with complicated urgent abdominal pathology is used in the most severe clinical situations. We have performed and published a systematic review (SR) and meta-analysis (MA) comparing vacuum-assisted laparostomy (VAC-LS) and other options for multi-stage surgical treatment. However, the results of randomized clinical trials (RCTs) and MA are often impossible to reproduce in real world-data (RWD). The aim: Evaluate the prerequisites for using the results of SR, MA in the RWD. Materials and methods: Based on the results of our secondary research study from 11 135 screened publications from 2007 to 2022, of which 33 are included in SR and 12 in MA. The results of MA and the data of the RWD of the hospital surgery clinic of the Volg State Medical University were compared. Results: VAC-LS has some advantages over other treatments, setting the stage for use in RWD. Conclusions: The results of the SR and MA performed by us have reasonable prerequisites for use in the RWD.
Study of hard tissues of the tooth crown using scanning electron microscopy and elemental analysis
Authors: Pavlova Tatyana V. , Pavlova Lyubov A. , Pavlova Oksana M. , Hazem Khseino , Novikov Vseslav Yu. , Kaplin Anton N. , Tverskaya Anastasia V. , Zatolokina Maria A.
Published: August 2024

The introduction of new methodological approaches actualizes research that makes it possible to establish relationships between the elemental composition of hard dental tissues and microscopic analysis data. Using scanning electron microscopy, the nature of the location and size of enamel prisms was revealed, and a description of the structure of the initial and final enamel was given. The zone of the dentino-enamel junction, the location of the dentinal tubules and the composition of the dentin matrix were studied. It has been proven that the content of water, organic matter, sodium and potassium is higher in dentin, and the concentration of magnesium, phosphorus and calcium is higher in enamel.
Evaluasi Program Pendidikan Karakter di Kelompok Bermain dan Taman Kanak-Kanak Candle Tree dengan Metode Context, Input, Process, dan Product (CIPP) [Evaluation of the Character Education Program in Candle Tree Playgroups and Kindergartens using the Context, Input, Process and Product (CIPP) Method]
Authors: Alvina Bella
Published: August 2024

It is crucial to instil character values from an early age, to have morally noble future generation, one is through character education program. The purpose of this study is to evaluate the character education program carried out by Candle Tree Kindergarten since 2018/2019, to improve, enhance and perfection. This evaluation adopts CIPP method, which is an acronym for Context, Input, Process, and Product. Qualitative and descriptive quantitative are employed to mutually promote evaluation results, questionnaire, interviews, observation, and documentation data collection methods were used. To interpret various standpoints of interest, different sources were taken, at the same time triangulation of sources were applied. The result on this study showed the evaluation of a) Context, it has potential and capability to implement the program, but the program objectives were integrated in school’s vision and mission; b) Input, in need of attention for program curriculum, budgeting, and variety of methods; c) Process, in need of improvement for virtual interaction, medium of instruction, assessment guides, frequency, and program documentation; d) Product, program results are in accordance with the characters instilled and it triggers other values. Therefore, it can be concluded that this evaluation can be useful for the management of KB-TK Candle Tree to develop character education programs.
Pengaruh Penguasaan Aplikasi Canva Terhadap Kinerja Guru di Sekolah Dasar Tarakanita Citra Raya [The Impact of Mastery of Canva Applications on Teacher Performance in Tarakanita Citra Raya Elementary School]
Authors: Wati Christiana Trisna , Istighfara Mutiara Dwima , Kumalasari Nugraheni Sri
Published: August 2024

<span class="NormalTextRun SCXW220392863 BCX0" data-ccp-parastyle="1.e. Abstract-text" data-ccp-parastyle-defn="{"ObjectId":"4d79b30c-66cc-4aaf-91cd-e0f5f5d7230b|12","ClassId":1073872969,"Properties":[469775450,"1.e. Abstract-text",201340122,"2",134233614,"true",469778129,"1eAbstract-text",335572020,"1",469777841,"Times New Roman",469777842,"Times New Roman",469777843,"SimSun",469777844,"Times New Roman",469769226,"Times New Roman,SimSun",268442635,"22",335551547,"1033",335559740,"220",201341983,"1",335559738,"200",335551550,"6",335551620,"6",469775498,"Normal",201342446,"1",201342447,"5",201342448,"1",201342449,"1",201341986,"1",335559704,"1025",335559705,"1033"]}">Mastering information technology has become an important part of education. Teachers need to develop and master various technology applications that support learning, one of which is the Canva application. This study was conducted on 27 teachers at SD Gambar Besar Tarakanita which aimed to determine the influence of mastery of the Canva application on teacher performance. The research method used is quantitative with research instruments in the form of questionnaires. The data analysis techniques used are simple correlation test and linear regression test. The results of the correlation analysis were obtained with a ratio of 0.42 compared to the table with a significance of 0.05 obtained H0 rejected. Analysis using linear regression obtained a calculated value of 5.46979835 with N=27 at a significance degree of 5%, then H0 was rejected. The results of the study show that there is a relationship and positive influence between mastery of the Canva application and teacher performance, which means that mastery of the Canva application will improve teachers' performance in teaching. So, it can be concluded that increasing teachers' ability to use technology, especially the Canva application, can improve their performance when teaching in the classroom.
Evaluation of Adulticidal Efficacy of Cypermethrin, Tetramethrin, and Piperonyl Butoxide in Housefly (Musca Domestica)
Authors: Licup Bianca Patricia E. , Purnamasari Listya , Olarve Joseph Penano , Dela Cruz Joseph Flores
Published: August 2024

Introduction: Houseflies serve as vectors of diseases in animals and humans. Chemical pesticides are a practical way of eliminating insects; however, resistance to insecticides has been reported. This study aims to evaluate the adulticidal efficacy of cypermethrin, tetramethrin, and piperonyl butoxide in housefly. Methods: Adult flies were cultured within net enclosures using completely randomized design with four replications each treatment. Treatment A was water and served as the negative control, treatment B was cypermethrin + tetramethrin + piperonyl butoxide 32% EC and served as the positive control, and treatment C was cypermethrin + tetramethrin + piperonyl butoxide 48% EC. The number of dead houseflies were counted 15, 30, 60, and 120 minutes post- application of treatments. The results were analyzed through analysis of variance (P≤0.05) followed by Tukey’s HSD (honestly significant difference). Results and Discussion: The values for the cumulative mean and percentage of killed houseflies were all significantly different from each other, with treatment C showing the highest values, followed by treatment B, then treatment A. The maximum adulticidal effect of treatment C was apparent within 15 minutes post-application, while the maximum adulticidal effect of treatment B was observed within 30 minutes after application. Conclusion: Results suggest that treatment C was a more effective adulticidal than other groups. Using cypermethrin + tetramethrin + piperonyl butoxide 48% EC can be the solution to the problem, but it should be noted that future resistance may occur. Increased concentrations may also imply environmental, human, and animal health hazards.
Smoke Free Regulation for Clean and Healthy Evironment in Blitar District Indonesia
Authors: Sri Widati  , Santi Martini  , Kurnia Dwi Artanti  , Hario Megatsari  , Priyono Adi Nugroho  , Amer Siddiq Amer Nordin
Published: August 2024

Introduction: The implementation of smoke-free regulations is an effort to create a clean and healthy environment in the Blitar District, Indonesia. The main purpose of this research is to analyze public opinion on the smoke-free regulations drafting in the Blitar District. Methods: To analyze public opinion about the smoke-free regulations, we used a cross-sectional design with a RAPID survey conducted in 2015. The research involved distributing questionnaires to 1,008 respondents, with the sample size proportionally divided across 22 districts. For the implementation of the regulation, we conducted observational research over four years. The effort to draft the smoke-free regulations continued until 2019, and the implementation of the regulations is ongoing until 2023. Results and Discussion: Results showed that 94.5% supported the regulations. The RAPID survey results provided evidence for drafting the smoke-free regulations. This evidence was used to advocate for stakeholder support in drafting and implementing the regulations in the Blitar District. Although the smoke-free regulations were released in 2019, their implementation has been very challenging and requiring significant effort. Conclusion: A RAPID survey showed that almost all people in Blitar support the drafting and implementation of the smoke-free regulations. The implementation requires significant effort to ensure it proceeds smoothly and needs support from all stakeholders in the Blitar District.
Identification of House Dust Mite and the Risk Factor of Cronic Itch in Elderly
Authors: Novyan Lusiyana  , Ekawati Suryaningsih Betty , Kuspriyono Onyxa , Widodo Chaerul
Published: August 2024

Introduction: Senile pruritus etiology is uncertain. However, well as intrinsic factors, one of the extrinsic risk factors causing pruritus is house dust mites (HDM) as. Aim of this study was to analyze the association between house dust mite density and the pruritus level among elderly residents. Methods: This is an observational study with cross-sectional design. The 34 elderly who met the criteria were included in this study. The pruritus level was obtained using questionnaire as to duration, degree, direction, disability, distribution (5D) itch scale based on NRS (numerical rating scale) categories divided into 4 categories (no, low, moderate, and severe itch). House dust mite density was checked using flotation method and the results categorized into low, moderate, and high density. The dust sample was checked for the species by microscope. The preventive activity to prevent the pruritus were also analyzed. The relationship between itch scale, preventive activity with HDM density was analyzed using STATA 17. Results and Discussion: A total of 34 elderly was included. Elderly were dominated with women (67.6%), moderate itch scale (38.2%) and moderate HDM density (58.8%). Most of the correlation between itch scale based NRS and preventive activity with HDM density p-value was not significant. But the elderly’s’ habit to clean the mattress was significantly correlated with HDM density (p=0.00). The Dermatophagoides sp were the dominant mites found in elderly’s’ room. Conclusion: Itch scale in elderly were not related with HDM density, but correlated with the habit to clean the mattress.
HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS
Authors: Peni Lis Widodo , Falah Pilar Menara , Nurdian Yudha
Published: August 2024

Background: Vaginal atrophy has occurred in three quarters of post-menopausal women. The exclusive source of post-menopausal sex hormones is dehydroepiandrosterone (DHEA). Purpose: Observe the impact of orally administered DHEA in the vagina of a rat (Rattus norvegicus) post- bilateral ovariectomy. Method: This experiment utilized 36 wistar rats aged 10 - 12 weeks with a body weight of 180 - 200 grams. The rats were randomly divided into two groups with an equal number of members. The control group was orally administered glycerin via gavage at a dose of 1 mL per day, while the treatment group received 7.2 mg of DHEA dissolved in glycerin, also administered orally via gavage at a daily dose of up to 1 mL. Both groups were maintained for 42 consecutive days. Finally, a histomorphology examination was conducted on the vaginal tissues of the sacrificed rats. Result: The mean of epithelial and smooth muscle thickness of the treatment group was significantly higher than that of the control group (p-value < 0.05). Besides, the number of blood vessels were also significantly higher in the treated group (p-value < 0.05). Conclusion: Administering DHEA orally via gavage enhances epithelial and smooth muscle tissue thickness, and augments the number of blood vessels in the vagina of wistar rats after bilateral ovariectomy.
Pediatrik Palyatif Bakımda Yatan Hastaların Klinik ve Demografik Özellikleri: Tek Merkez Deneyimi
Authors: Aldaş Şefika , Ersoy Özlem , Şahin Şanlıay
Published: August 2024

Günümüzde pediatrik palyatif bakıma olan talep ve gereksinim giderek artmaktadır. Bu nedenle, Mersin'deki pediatrik palyatif merkezinde son altı ay içinde yatan hastaların klinik ve demografik özelliklerini değerlendirmeyi ve bu alanda edindiğimiz deneyimleri paylaşmayı hedefledik. Mersin Şehir Eğitim ve Araştırma Hastanesi Çocuk Palyatif Bakım Servisi'nde, 01/06/2023 ile 01/01/2024 tarihleri arasında takip edilen, 1 ay ile 18 yaş aralığındaki yatan hastaların dosyaları retrospektif olarak incelendi. Çalışmaya dahil edilen 279 hastanın (%59.1 erkek, %40.9 kız) medyan yaşı 62 ay ve medyan yatış süresi 7 gün olarak belirlendi. En yaygın yatış tanısı %42.7 ile serebral palsi ve mental motor retardasyondu. Malignite ise %0.7 ile en az görülen yatış tanılarından biri idi. Yatış nedenleri arasında alt solunum yolu enfeksiyonları (%46.2) ve nöbet sıklığında artış (%20.8) öne çıkmaktaydı. Hastaların %32.6’sı yoğun bakım sonrası tedavi için kabul edilmişti. %69.5'i Türkiye Cumhuriyeti vatandaşı iken, şehir dışından gelen hasta sayısı %15.8'di. %67.4'ü çocuk acil servisinden, %32.6'sı yoğun bakım ünitelerinden kabul edilmişti. %17.2'sinde trakeostomi mevcuttu ve ev tipi mekanik ventilatör bağımlıydı. Beslenme gereksinimi olan hastaların %10'u nazogastrik tüp, %20'si ise perkütan endoskopik gastrostomi ile beslenmekteydi. Hastaların %11’inde ventriküloperitoneal şant mevcuttu. Bası yarası %6.5'inde tespit edildi. %93.2'si taburcu edilirken, %6.1'i çocuk yoğun bakım ünitesine devredildi. Sonuç olarak, 15 hasta yaşamını yitirdi. Onkolojik hastaların takibi ve desteklenmesi için daha fazla kaynağa ihtiyaç vardır. Pediatrik palyatif bakımın daha geniş kapsamda ele alınması ve bu alandaki eksikliklerin giderilmesi için ileri çalışmalara ihtiyaç duyulmaktadır.