bluuebunny/crossref_metadata_2025 huggingface dataset:
Model pembelajaran pola sidang pengadilan: Suatu kerangka teoretis
Authors: Kurniawan Bayu , Purnomo Agus , Ratnawati Nurul
Published: July 2022

The development of the learning model is now a trend in learning innovation. These innovations need to answer every challenge in education. This article aims to: 1) describe the syntax of court-session based learning, 2) analyze the philosophical foundation of court-session based learning, and 3) analyze the theoretical framework of court-session based learning. The method used in this study is library research. Based on the findings, this learning model has a syntax that adapts the implementation of the court session. The division of students is carried out based on the role of each group (Team of Judge, Team of Defendant, Team of Lawyer, and Team of Prosecutor). The philosophical foundation of this learning model is through the paradigm of constructivists Jean Piaget and Vygotsky. This learning models use constructivism theory for the rationale.

Pengembangan model pembelajaran saat ini menjadi tren dalam inovasi pembelajaran. Inovasi ini perlu dialkukan untuk menjawab setiap tantangan dalam pendidikan. Artikel ini bertujuan untuk: 1) mendeskripsikan sintak model pembelajaran pola sidang pengadilan, 2) menguraikan landasan filosofis, dan 3) landasan teoretis dari model pembelajaran pola sidang pengadilan. Metode yang digunakan dalam penelitian ini adalah kajian kepustakaan (library research). Hasil penelitian menyatakan bahwa model pembelajaran ini memiliki sintak yang mengadaptasi pelaksanaan sidang pengadilan. Pembagian kelompok peserta didik dilakukan berdasarkan peran kelompok masing-masing (Tim Hakim, Tim Terdakwa, Tim Pengacara, dan Tim Jaksa Penuntut Umum). landasan filosofis dari model pembelajaran ini adalah berdasarkan paradigma konstruktivistik Jean Piaget dan Vygotsky. Teori belajar yang dignakan juga menggunakan konstruktivisme.
Analisis daya tarik wisata Pulau Merah sebagai objek wisata berbasis alam
Authors: Risdarani Yucha , Ardiyanto Giofani Ginolla , Nurdin Elan Artono , Pangastuti Era Iswara
Published: July 2022

Pulau Merah is a natural tourist attraction in the form of a beach located in the Banyuwangi Regency area, precisely in the Pesanggaran District. This beach is one of several tourist destinations in Banyuwangi. Which of these tours is quite in demand, because it offers a natural charm that attracts many tourists. The purpose of this study is to find out and analyze the attractiveness of the Pulau Merah tourist attraction as a nature-based tourist attraction and the current condition of the Pulau Merah. This research uses a qualitative approach and is presented in a descriptive form that focuses on aspects of physical condition and attractiveness. The data obtained in this study are derived from the author's direct observations in the field, interviewing sources, and other secondary data. The development of the Pulau Merah tourism object which is increasingly recognized by many people shows that the promotion and tourism development media carried out by the Banyuwangi Regency government are quite successful. However, the pandemic period in the last year has greatly impacted tourism actors on Pulau Merah Beach.

Pulau Merah merupakan obyek wisata alam berupa pantai yang bertempat pada wilayah Kabupaten Banyuwangi, tepatnya ada di Kecamatan Pesanggaran. Pantai ini merupakan salah satu dari beberapa destinasi wisata di Banyuwangi. Yang mana wisata ini yang cukup diminati, karena menawarkan pesona alam yang menarik banyak wisatawan. Tujuan dari penelitian ini yakni guna mengetahui dan menganalisis daya tarik objek wisata Pulau Merah sebagai objek wisata berbasis alam serta kondisi Pulau Merah saat ini. Dalam penelitian ini menggunakan metode pendekatan secara kualitatif dan disajikan dalam bentuk deskriptif yang berfokus pada aspek kondisi fisik dan daya tarik. Data yang didapat pada penelitian ini yakni berasal dari pengamatan penulis secara langsung di lapangan, mewawancarai narasumber dan data sekunder lainnya. Perkembangan obyek wisata Pulau Merah yang semakin dikenal banyak orang menunjukkan bahwa media promosi dan pengembangan pariwisata yang dilakukan oleh pemerintah Kabupaten Banyuwangi cukup berhasil. Namun dikarenakan adanya masa pandemi pada satu tahun terakhir ini sangat berdampak bagi pelaku wisata yang ada di Pantai Pulau Merah.
Mental Revolution, Youth, and Environmental Issues in Indonesia
Authors: Roziqin Ali , Sumiarto Rasongko S. , Aziz Fadian Nur
Published: July 2022

The Mental Revolution in Indonesia is a strategic and instrumental policy initiated by Joko Widodo's government to improve its mentality and morality. However, since its implementation, a mental revolution is like jargon. The impact of the mental revolution has not been significant, especially youth and environmental issues. Environmental damage still occurs and tends to be massive, and many young people are less aware of environmental sustainability. This article aims to analyze development of the mental revolution from a youth perspective and its role on environmental sustainability issues in Indonesia. Using literature study and document analysis methods, the results show that mental revolution from a youth perspective and its role in environmental sustainability issues has become an interesting issue for discussion at the national and international levels. Mental revolution must be able to improve the character of today's youth. In addition, youth as agents of change need to review the damage and disasters caused by the greedy character of a small portion of the community.

Revolusi Mental di Indonesia merupakan kebijakan strategis dan instrumental yang digagas oleh pemerintahan Joko Widodo untuk meningkatkan mentalitas dan moralitasnya. Namun, sejak implementasinya, revolusi mental seperti jargon. Dampak dari revolusi mental ini belum signifikan, terutama masalah pemuda dan lingkungan. Kerusakan lingkungan masih terjadi dan cenderung masif, serta banyak generasi muda yang kurang sadar akan kelestarian lingkungan. Komentar ini bertujuan untuk menganalisis perkembangan revolusi mental dari perspektif pemuda dan perannya dalam isu-isu kelestarian lingkungan di Indonesia. Dengan menggunakan metode studi literatur dan analisis dokumen, hasil penelitian menunjukkan bahwa revolusi mental dari perspektif pemuda dan perannya dalam isu kelestarian lingkungan telah menjadi isu yang menarik untuk dibahas di tingkat nasional dan internasional. Revolusi mental harus mampu meningkatkan karakter pemuda masa kini. Selain itu, pemuda sebagai agen perubahan perlu meninjau kembali kerusakan dan bencana yang ditimbulkan oleh karakter rakus sebagian kecil masyarakat.
Analisis penyebab anak putus sekolah pada jenjang pendidikan SD dan SMP di Desa Sidorahayu Kecamatan Wagir Kabupaten Malang
Authors: Wardani Yohana Devi , Ruja I Nyoman , Towaf Siti Malikhah , Efendi Bintang Muhammad Sahara , Kurniawan Novian Candra
Published: July 2022

This study aims to describe the causes of children dropping out of school in Sidorahayu Village, Wagir District, Malang Regency. The approach and type of research used is descriptive qualitative. The results showed that: the causes of children dropping out of school at the elementary and junior high school levels in Sidorahayu Village, namely the first social conditions of parents consisting of parental education and parental occupation. Second, the economic condition of the parents consists of the income of the parents and the burden of their dependents. Third, child psychology consists of children's interests or motivations, environment, and health.

Penelitian ini bertujuan untuk mendeskripsikan penyebab anak putus sekolah di Desa Sidorahayu Kecamatan Wagir Kabupaten Malang, kondisi psikologis anak, implikasi teori konstruksi, harapan dan solusi dari anak putus sekolah. Pendekatan dan jenis penelitian yang digunakan kualitatif deskriptif. Hasil penelitian menunjukan bahwa: penyebab anak putus sekolah pada jenjang pendidikan SD dan SMP di Desa Sidorahayu yaitu pertama kondisi sosial orang tua yang terdiri dari pendidikan orang tua serta pekerjaan orang tua. Kedua, kondisi ekonomi orang tua terdiri dari penghasilan orang tua serta beban tanggungan orang tua. Ketiga, psikologi anak yang terdiri dari minat atau motivasi anak, lingkungan dan juga kesehatan.
Modal sosial pemberdayaan perempuan UMKM Batik Tulis Pinang Desa Capang Kecamatan Purwodadi Kabupaten Pasuruan
Authors: Aini Desi Nur , Wahyunigtyas Neni , Kurniawan Bayu
Published: July 2022

Social capital becomes important aspect in the empowerment of women in Batik Pinang MSMEs. Social capital serves as the formation of social networks among female members of Batik Pinang MSMEs. Type of descriptive qualitative research. Miles and Huberman's interactive model as a data analyst technique. The results are: 1) The form of social capital are cooperation and mutual kindness; relations with external parties and women's participation; nonformal norms bind social networks. 2) The encouragement of women empowerment are from outsider, the interest and motivation. The inhibitory factor are minimal singing facilities and doubts about the purchasing power of batik tulis.

Modal sosial menjadi aspek penting dalam pemberdayaan perempuan di UMKM Batik Pinang. Modal sosial berfungsi sebagai pembentuk jaringan sosial diantara perempuan anggota UMKM Batik Pinang. Jenis penelitian deskriptif kualitatif. Model interaktif Miles dan Huberman sebagai teknik analisi data. Hasil penelitian menunjukkan: 1) Bentuk modal sosial di UMKM Batik Pinang berupa; kerjasama dan timbal balik kebaikan; relasi dengan pihak eksternal serta partisipasi perempuan; norma non-formal pengikat jaringan sosial. 2) Dorongan pemberdayaan perempuan di UMKM Batik Pinang dari pihak luar serta adanya minat dan motivasi perempuan terhadap kerajinan membatik. Adapun faktor penghambat disebabkan fasilitas membatik minim serta keraguan daya beli batik tulis.
Perspektif feminisme dalam kepemimpinan perempuan di Indonesia
Authors: Da Meisa Eggi Alvado , Anzari Prawinda Putri
Published: July 2022

Leaders have an important role in providing enthusiasm, the quality of a group being led, and also the level of achievement that can be achieved. A leader is someone who has skills and advantages, especially in skills and strengths in a particular field, so that he is able to influence others to jointly carry out certain activities in order to realize certain goals and achievements. The focus of this research is on the influence of women in leadership in Indonesia, and how the feminist perspective sees women as leaders in Indonesia. The method used in the study uses a library approach. This literature study is a method by collecting library data through books, related journals, documents (both printed and electronic). Then the results of this study show that women's leadership in Indonesia has shown that they are women who are able to prove and achieve success as leaders. The role of women in leadership in Indonesia from all aspects of the field has shown that women are also capable and worthy to be leaders.

Pemimpin memiliki peranan penting dalam memberikan semangat, kualitas dari suatu kelompok yang dipimpin, dan juga tingkat prestasi yang bisa dicapai. Seorang pemimpin merupakan seseorang yang memiliki kecakapan dan kelebihan, khususnya pada kecakapan dan kelebihan pada satu bidang tertentu, sehingga ia mampu mempengaruhi orang lain untuk bersama-sama melakukan aktivitas tertentu demi mewujudkan suatu tujuan dan pencapaian tertentu. Fokus penelitian ini diantaranya mengenai pengaruh perempuan dalam kepemimpinan di Indonesia, serta bagaimana perspektif feminisme melihat sosok perempuan menjadi pemimpin di Indonesia. Metode yang digunakan dalam penelitian menggunakan pendekatan kepustakaan. Studi kepustakaan ini merupakan metode dengan mengumpulkan data pustaka melalui buku-buku, jurnal terkait, dokumen-dokumen (baik cetak maupun elektronik). Kemudian hasil dari penelitian ini menunjukkan bahwa kepemimpinan perempuan di Indonesia telah menunjukkan bahwa mereka para kaum perempuan mampu membuktikan dan mencapai suatu keberhasilan sebagai pemimpin. Peran perempuan dalam kepemimpinan di Indonesia dari segala aspek bidang telah menunjukkan bahwa perempuan juga mampu dan layak dijadikan seorang pemimpin.
Pengaruh minuman keras terhadap nilai-nilai kebudayaan Jawa sebagai fenomena patologi sosial di Kota Malang
Authors: Shiona Altlya Elok Yearmil , Lintang Daniel Johannes , Hartono Firli Maulidyah , Faris Ilham Salim Iqfatul , Renaningtyas Lely Rara , Munikha Nilnada , Fibrianto Alan Sigit
Published: July 2022

Culture came and was brought by the ancestors of the Indonesian nation. Hereditary inheritance from one generation to another is related to the way of outlook and life guidance of a nation. Javanese culture has a value of politeness and simplicity that is still upheld in Javanese society. However, as times are getting more advanced, the existence of these cultures is fading and disappearing. This study focuses on how the influence of alcohol on Javanese cultural values as a social pathology phenomenon in Malang City. This study used a descriptive qualitative method with primary and secondary data collection. In analyzing research problems, Emile Durkheim's anomie theory and Emile Durkheim's concept of social solidarity. The results showed that drinking-alcoholic behavior could not be separated from several factors that influence it. This behavior is inversely proportional to the existing culture. Javanese culture upholds a sense of simplicity and politeness.

Kebudayaan datang dan dibawa oleh nenek moyang bangsa Indonesia. Warisan secara turun temurun dari satu generasi ke generasi yang lain berkaitan dengan cara pandangan dan tuntunan hidup suatu bangsa. Kebudayaan Jawa mempunyai nilai kesopanan dan kesederhanaan yang masih terus dijunjung tinggi dalam masyarakat Jawa. Namun, jaman yang semakin maju, keberadaan budaya tersebut semakin luntur dan menghilang. Penelitian ini berfokus pada bagaimana pengaruh minuman keras terhadap nilai-nilai kebudayaan Jawa sebagai fenomena patologi sosial di Kota Malang. Penelitian ini menggunakan metode kualitatif deskriptif dengan pengumpulan data secara primer dan sekunder. Dalam menganalisis permasalahan penelitian teori anomie dari Emile Durkheim serta konsep solidaritas sosial dari Emile Durkheim. Hasil penelitian menunjukkan perilaku minum-minuman keras tidak dapat dapat terlepas dari beberapa faktor yang mempengaruhinya. Perilaku tersebut berbanding terbalik dengan kebudayaan yang ada. Kebudayaan Jawa menjunjung tinggi rasa kesederhanaan dan kesopanan.
Penolakan aktivitas tambang pasir dan konflik sosial di Kabupaten Lumajang, Jawa Timur
Authors: Putri Adinda Novalia Retnaning , Rifqi Dimas Aulia , Prakris Maria Apolonia , Khalaidah Khairunnisa Amalia , Amanda Umiliya Arfah , Kodir Abdul
Published: July 2022

As we know that Indonesia is one of the nations with abundant natural potential, which is caused by it’s adequate natural resources. These days, we are familiar with a lot of utilization of our natural resources, which one of them is mining. But if we see from day to day, this utilization term got misused by some part of company to hide their exploitation act towards the nature. Like the minning case that have been done by PT Indo Modern Minning Sejahtera (PT IMMS) in Lumajang regency, East Java. This minning activity got a lot of criticism from the citizens around the area because it is considered to conduce another natural problems caused by the lack of company’s management and attention towards its waste and former mining land, until an exhalation illness (which is in this case is ISPA) that infected many of citizens because of the pollution from mining activity. The rejection against this mining activity finally culminate to violence act from PT IMMS (by sending their people) towards two local citizens around the area. This article is rely on literature studies, which is the writer collect some trusted news related to this mining problem. This case was analized by using vertical conflict concept which put forward by Karl Marx, and then reviewed with social conflict in an organization.

Seperti yang sudah kita ketahui bahwa Indonesia adalah salah satu negara dengan potensi alam yang melimpah, dikarenakan sumber daya alamnya yang sangat memadai. Pada hari ini kita sudah tidak asing lagi dengan berbagai penggunaan sumber daya alam, salah satunya ialah pertambangan. Namun, bila dilihat dari hari ke hari, istilah pemanfaatan ini kemudian disalahgunakan oleh beberapa pihak untuk menutupi tindakan eksploitasi. Layaknya kasus pertambangan yang dilakukan oleh PT Indo Modern Mining Sejahtera (IMMS) yang terjadi di kabupaten Lumajang, Jawa Timur. Aktivitas pertambangan ini banyak dikecam oleh warga sekitar karena menimbulkan masalah alam lainnya akibat kurangnya pengelolaan dan perhatian perusahaan terhadap limbah dan lahan bekas pertambangan, hingga penyakit pernafasan (ISPA) yang menjangkit para warga akibat terpapar polusi dari aktivitas pertambangan. Penolakan ini juga berujung pada terjadinya kekerasan fisik terhadap warga yang menentang adanya aktivitas tambang oleh preman-preman dari pihak PT IMMS. Artikel ini ditulis mengandalkan studi literatur, dimana penulis mengumpulkan berita terkait permasalahan aktivitas pertambangan PT IMMS dari sumber terpercaya. Kasus ini kemudian penulis analisa menggunakan konsep konflik vertikal yang dikemukakan oleh Karl Marx, serta dikaji menggunakan konsep konflik sosial dalam sebuah organisasi.
Marginalisasi perempuan dalam ranah publik (analisis wacana kritis Sara Mils dalam film Kim Ji Young Born 1982)
Authors: Larasati Wulan Putri , Anzari Prawinda Putri
Published: July 2022

The film Kim Ji Young Born 1982 is one of the South Korean films that is based on the reality that occurs in society, especially in the Asian region, this film is adapted from the novel by Cho Nam Jo of the same title. This film tells about the main character named Kim Ji Young who since childhood has always received unfair treatment, this treatment continues until Ji Young goes to school, works, and even gets married. Even though South Korea is counted as a developed country, the patriarchal culture in that country is still very strong. The approach used in this film is a qualitative approach with Sara Mils' critical discourse analysis method, Sara Mils' critical discourse analysis model emphasizes more on how the position of the actor is shown. in the text. The purpose of this study is to find out how women are treated differently in work, especially in the public sphere. The difference between this research and previous research lies in the method used, namely Sara Mils' critical discourse analysis method.

Film Kim Ji Young Born 1982 adalah salah satu film Korea Selatan yang diangkat dari realitas yang terjadi di masyarakat khususnya daerah Asia, film ini diadaptasi dari novel karya Cho Nam Jo dengan judul yang sama. Film ini menceritakan tentang tokoh utama bernama Kim Ji Young yang sejak kecil selalu menerima perlakuan tidak adil, perlakuan tersebut terus berlanjut sampai Ji Young sekolah, bekerja, bahkan hingga menikah. Meskipun Korea Selatan terhitung sebagai negara maju, budaya patriarki yang ada di Negara tersebut masih tergolong sangat kental Pendekatan yang digunakan dalam film ini adalah pendekatan kualitatif dengan metode analisis wacana kritis Sara Mils, model analisis wacana kritis Sara Mils lebih menekankan pada bagaimana posisi actor yang ditampilkan dalam teks. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana perempuan diperlakukan berbeda dalam pekerjaan khususnya pada ranah public. Perbedaan penelitian ini dengan penelitian sebelumnya adalah terletak pada metode yang digunakan yaitu metode analisis wacana kritis Sara Mils.
Islam-Jawa: Makna simbolis seni pewayangan "tokoh Semar"
Authors: Subarkah Muhaimin , Ayundasari Lutfiah
Published: July 2022

Islam and Java are something that are familiar to us from the presence of Islam in Javanese culture. Java has so many rituals or cultures that have such symbolic value. However, these values are not merely meanings that are considered as complements. However, there are elements of Islam that have influenced Javanese culture so far. There are also many people who do not understand the Islamic elements of Javanese culture, so most of them say that the culture is heretical. Therefore, the author tries to explain the symbolic meaning of Islam and Java in one of the Semar puppet characters who has a high philosophical value for life and also Islam itself. The results of this study are expected to get a lot of information from this study, this study also explores philosophies that have meaning in life, in accordance with the Javanese society order, and are also expected to know that the cultures, traditions, principles under Javanese ancestry are acculturate Java and Islam, do not misunderstand and say our ancestors are deviant.

Islam dan Jawa merupakan sebuah hal yang tidak asing bagi kita terhadap hadirnya Islam dalam kebudayaan Jawa. Jawa yang memiliki begitu banyak ritual atau kebudayaan yang begitu memiliki nilai simbolis. Namun nilai tersebut tidaklah hanya makna – makna belaka yang dianggap sebagai pelengkap saja. Tetapi ada unsur – unsur Islam yang mempengarusi terhadap budaya Jawa selama ini. Banyak juga mereka yang tidak mengerti akan unsur Islam terhadap budaya Jawa sehingga kebanyakan dari mereka mengatakan budaya tersebut sesat. Maka dari itu penulis berusaha untuk menjelaskan tentang makna simbolis Islam dan Jawa dalam salah satu tokoh pewayangan Semar yang begitu memiliki sebuah nilai filosofis tinggi terhadap kehidupan dan juga Islam itu sendiri. Hasil dari penelitian ini, diharapkan mendapatkan banyak informasi dari kajian ini, kajian ini juga menggali filosofis-filosofis yang memiliki makna dalam kehidupan, sesuai dengan tatanan masyarakat Jawa, dan juga diharapkan dapat mengetahui bahwa budaya-budaya, tradisi, prinsip yang dibawah leluhur Jawa dengan mengakulturasi Jawa dan Islam, tidak menjadi salah paham dan mengatakan leluhur kita sesat.
Kritik Holistik pada Lukisan Paranoid Karya Gatot Pujiarto Tahun 2021
Authors: Tauriska Dinda Ayu , Sumarwahyudi Sumarwahyudi , Anggraini Swastika Dhesti
Published: July 2022

Abstract: Artwork is an embodiment of the artistic value, so that the object can emit the observer’s feelings. The purpose of this study is to find out the artistic background of Gatot Pujiarto, the values contained in the work 'Paranoid', and to find out the reasons that cause 'Paranoid' to bring out certain feelings. The researcher chose to use descriptive qualitative research and a holistic approach in order to achieve more concrete results by considering the three main components of the artwork. Namely works of art, artists, and observers. The results of this study are: (1) Gatot Pujiarto has been in the art field since childhood and has received a lot of support from his family and relatives, (2) the painting 'Paranoid' contains social values because the theme it brings is about the condition of society when facing a pandemic. COVID-19, and (3) every component in the painting 'Paranoid' plays a role in causing a feeling of tightness and chaos. Among them are the choice of colors that are low in saturation, the size of the work is quite large, as well as scattered threads and fabrics. Even though the work 'Paranoid' gives rise to multiple interpretations in each of its components, in general the work carries a message about the crowded situation during the COVID-19 pandemic.
Keywords: painting; Gatot Pujiarto; holistic critique; COVID-19
Abstrak: Karya seni adalah perwujudan dari nilai seni yang membenda, sehingga benda tersebut dapat memunculkan perasaan haru oleh penghayatnya. Tujuan dari penelitian ini adalah untuk mengetahui latarbelakang berkesenian Gatot Pujiarto, nilai-nilai yang terkandung pada karya ‘Paranoid’, serta mengetahui alasan yang menyebabkan ‘Paranoid’ dapat memunculkan perasaan tertentu pada peng­hayat. Peneliti memilih untuk menggunakan jenis penelitian deskriptif kualitatif dan pendekatan holistik demi mencapai hasil yang semakin konkrit dengan mempertimbangkan ketiga komponen utama karya seni. Yaitu karya seni, seniman, dan penghayat. Hasil dari penelitian ini adalah: (1) Gatot Pujiarto sudah berkecimpung pada bidang seni sejak kecil dan banyak mendapatkan dukungan dari keluarga dan kerabatnya, (2) lukisan ‘Paranoid’ mengandung nilai-nilai sosial karena tema yang dibawa adalah mengenai kondisi masyarakat saat menghadapi pandemi COVID-19, dan (3) setiap komponen pada lukisan ‘Paranoid’ berperan dalam menimbulkan rasa sesak dan kalut. Diantaranya adalah pilihan warna yang bersaturasi rendah, ukuran karya yang cukup besar, serta benang dan kain yang berserakan, Meskipun karya ‘Paranoid’ menimbulkan multitafsir pada tiap komponennya, akan tetapi secara garis besar karya tersebut mengusung pesan mengenai keadaan sesak kala pandemi COVID-19 berlangsung.
Kata kunci: lukisan; Gatot Pujiarto; kritik holistic; COVID-19
Philanthropies as partners for drug development in public–private partnerships
Authors: D. Lim Mark , A. Brumfield Martha , Goldman Michel
Published: July 2022

Disease-focused philanthropic organizations play an increasing role in the strategy and conduct of biomedical research, with many focusing on drug development for specific diseases and patient populations. More and more they not only provide resources and expertise, but also take active part managing the strategy and objectives of targeted research programs, using approaches such as venture philanthropy. Many also lead and participate in public–private partnerships. One example is the partnership between the Polycystic Kidney Disease (PKD) Foundation and the Critical Path Institute (C-Path) which brings together several pharmaceutical companies and academic institutions to develop new broadly-used biomarkers. Another case is the partnership between JDRF (formerly known as the Juvenile Diabetes Research Foundation) and the Innovative Medicines Initiative (IMI), involving financial support of the IMIDIA project (Innovative Medicines Initiative for Diabetes) which is focused on improving beta-cell function and identifying biomarkers for diabetes treatment monitoring. These examples show that in addition to providing financial support and expertise, philanthropic foundations are also in a unique position to coordinate the patient and research communities to enable and accelerate specific medicines development projects.
TransCelerate: a global collaboration across biopharmaceutical R&D to accelerate and simplify new medicines development
Authors: Marks Lynn
Published: July 2022

As the economic pressures increase on healthcare systems around the world due to aging populations, chronicdiseases, expanding patient populations in emerging markets and advances in medical technology, it is crucial that wefocus on developing and delivering innovative and quality medicines with true medical value to patients around theworld in a more collaborative, quality-focused and cost-effective manner.An important component to this mission across the biopharmaceutical industry is identifying and solving common issues that compromise the success of a clinical development program – the shared pathway to safer and more clinicallymeaningful medicines. However, subject recruitment challenges, data collection and follow-up issues, identification ofhigh-quality trial sites, and lack of successfully achieving study timelines continue to stress clinical trial operationsteams across companies. Although there has been progressing across this range of roadblocks by individual companies,the underlying economics continue to threaten the research and development (R&D) business model.Failure to solve these key issues will affect all parties involved in the clinical trial enterprise: patients, clinical investigators, health authorities, academia, tax-payers and the sponsor companies. The question remains whether a deep andbroad collaborative effort that stretches across the clinical development arena—one that is charged with a common goalof improving quality, enhancing the investigator and patient experience, reducing costs and sharing data—can be acatalyst for success. With encouraging signs already realised, the operation of TransCelerate BioPharma Inc., anon-profit organisation created to improve the health of people around the world by accelerating and enhancing theR&D of innovative new therapies will test this premise.
Cell therapy for bone fracture repair: A comparative preclinical review of mesenchymal stromal cells from bone marrow and from adipose tissue
Authors: Ena Sabrina , Ino Julia , Neirinck Aurelie , Pietri Sandra , Tury Anna , Bastianelli Enrico
Published: July 2022

Over the last decade, there has been an increasing interest among researchers for human mesenchymal stromal cells (MSC). Their regenerative properties, multilineage differentiation capacity and immunomodulatory properties make them promising candidates for treatment in various conditions. Emerging biotechnology companies specialized in cellular and regenerative therapies have been focusing their interest on MSC-based therapies, and their use in clinical trials has steadily increased. Notably, MSC are currently tested in clinical trials addressing unmet medical needs in the field of bone fracture repair and more specifically in non-union and delayed union fractures where the bone repair process is impaired. Although MSC can be isolated from various tissues, the most commonly studied sources are bone marrow (BM) and adipose tissue (Ad). In this article, we reviewed the literature directly comparing BM- and Ad-MSC for their in vitro characteristics and in vivo osteogenic potential to determine which source of MSC would be more appropriate for bone fracture repair. As considerable variations in experimental settings between studies were found, our review was based on studies meeting specific sets of criteria, notably regarding donors’ age and gender. This review of side-by-side comparisons suggests that while BM-and Ad-MSC share common general characteristics, BM-MSC have a higher intrinsic osteogenic capacity in vitro and bone repair potential in vivo.
HDL therapies — past, present and future
Authors: Barbaras Ronald
Published: July 2022

For a number of years, high-density lipoprotein (HDL) has been recognized to have an athero-protective role by promoting reverse lipid transport, a process facilitating the cholesterol efflux from atherosclerotic plaques in the artery wall and its elimination by the liver via biliary excretion.On the contrary, low-density lipoprotein (LDL) particles carry cholesterol to the organs and tissues where it can be used to produce hormones or maintain cell metabolism. When an imbalance develops, as a result of either an excess level of cholesterol associated with LDL (LDL-C) or a less effective cholesterol elimination by HDL (HDL-C), this causes an excess of cholesterol to be transported to the tissues and promotes the deposition of cholesterol. This often occurs in the artery walls, particularly in the coronary arteries. There is no approved medical treatment for directly suppressing or treating the atherosclerotic plaque once it is formed. Epidemiological studies have shown that the risk of developing cardio-vascular disease (CVD) is higher in patients with low levels of HDL-C regardless of LDL-C levels, even in patients optimally treated with LDL-C-lowering therapies. These data highlight that low HDL-C and low HDL particle number is an important target of therapies aiming to reduce the residual risk of CVD.
Medicines development and regulation in Africa
Authors: Rosenkranz Bernd , Reid Michael , Allen Elizabeth
Published: July 2022

Africa is one of the world’s fastest-growing economic regions, with a rise in its pharmaceutical industry value from $4.7 billion in 2003 to $20.8 billion in 2013. Multinational pharmaceutical companies are becoming more active in drug production and clinical trials across Africa, and there is an increase in the number of local companies engaged in medicines development and marketing. Such expansion of the local pharmaceutical industry requires trained pharmaceutical specialists to support it. The current situation and future requirements for local medicines development, regulation, education and training needs are discussed.
Role of the P2Y6 receptor of UDP in the modulation of murine dendritic cell functions and Th1 polarisation of the immune response
Authors: Cammarata Dorothée , Ben Addi Abduelhakem , D’Amico Eva , Robaye Bernard
Published: July 2022

Numerous studies have demonstrated the role of uridine diphosphate (UDP) and its P2Y6 receptor in the inflammatory reaction and innate immunity. However, the importance of the P2Y6 receptor in the adaptive immune response remains unclear. In this study, we demonstrate that the P2Y6 receptor is functionally expressed in murine bone marrow dendritic cells (BMDC). UDP induced a Ca2+ transient in these cells that was decreased in P2Y6-deficient mice. UDP also increased the endocytosis of fluorescein isothiocyanate-dextran (FITC-dextran) and amplified the secretion of interleukin 12-p70 (IL-12p70) induced by CpG; these responses were abolished in P2Y6-deficient mice. In vivo experiments showed  that the serum level of specific IgG2c after immunisation with ovalbumin was decreased in P2Y6-deficient mice, while the level of specific IgG1 was unchanged. These data suggest that the P2Y6-mediated effects of UDP on myeloid dendritic cells play a role in the in vivo Th1 skewing of the immune response.
Medicines development in the Asia Pacific region
Authors: Elegant Victoria
Published: July 2022

The Asia Pacific region is an extremely diverse region, characterized by heterogeneity from a number of aspects, including culture, religion, economics, landscapes, and languages. This also applies to the standard of medical care and the regulatory requirements for approval of drugs in the region. Developed economies such as Japan and Australia have requirements which are not dissimilar to those of the EU and USA, but still have their own unique requirements. The developing economies all have their own requirements. In the ASEAN region there is harmonization of the dossier format, but each country still has local requirements. The region has seen significant growth in clinical trial activity, both to satisfy local registration and safety requirements and to help accelerate global trial patient recruitment. There is a clear need for training in all aspects of medical, regulatory, clinical and safety aspects of medicines development, which is being addressed through several organizations and at different locations in the region.
Risk of anxiety and depression in patients with uveitis: a Meta-analysis
Authors:   Senior Department of Ophthalmology, the Third Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing 100039, China, Cui Bei , Gao Li-Xiong ,   Senior Department of Ophthalmology, the Third Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing 100039, China, Dong Xiao-Fei ,   Department of Ophthalmology, No.967 Hospital of the Joint Logistics Support Force of the Chinese PLA, Dalian 116000, Liaoning Province, China
Published: July 2022

AIM: To quantitatively evaluate the risk of anxiety and depression in patients with uveitis via performing a Meta-analysis.
METHODS: Three electronic database (PubMed, Embase, and Cochrane Library databases) were searched for studies recording data about uveitis and anxiety as well as depression simultaneously up to January 2021. The incidence rate and standard mean difference (SMD) with a 95% confidence interval (95%CI) were calculated to analyse the association using random-effects models based on heterogeneity tests.
RESULTS: In total, 12 observational studies containing 874 patients with uveitis were included. The results showed that there was a significant association between uveitis and anxiety (SMD=0.97, 95%CI: 0.39 to 1.54, P=0.0009) and depression (SMD=0.79, 95%CI: 0.51 to 1.07, P<0.00001). The overall morbidities of anxiety and depression in patients with uveitis were 39% and 17%, respectively. With subgroup analysis, the heterogeneity actually came from different kinds of uveitis. Specifically, the incidence rates of both anxiety and depression were relatively low in patients with anterior uveitis (33% and 15%), moderate in patients with infectious uveitis (46% and 22%), and high in patients with unspecified uveitis (59% and 35%).
CONCLUSION: It is preliminarily indicated that patients with uveitis may have a high risk of anxiety and depression. Ophthalmologists and psychologists should pay more attention to the psychological state when dealing with patients with uveitis. Further high-quality studies with detailed direct data are needed to draw more precise conclusions.
Advances in the research of plant-derived natural products against retinoblastoma
Authors:   Department of Ophthalmology, Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine, the Fourth Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330003, Jiangxi Province, China; School of Clinical Medicine, Dali University, Dali 671000, Yunnan Province, China; School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China, Liu Jing-Chen , Dong Kai-Ye ,   Department of Ophthalmology, the First Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, China, Li Ming-Jun ,   School of Clinical Medicine, Dali University, Dali 671000, Yunnan Province, China, Sun Shu-Guang ,   School of Clinical Medicine, Dali University, Dali 671000, Yunnan Province, China; Department of Endocrinology, the First Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, China, Li Cai-Rui ,   School of Clinical Medicine, Dali University, Dali 671000, Yunnan Province, China; Department of Ophthalmology, the First Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, China
Published: July 2022

Retinoblastoma (RB) is a highly aggressive ocular tumor, and due to socioeconomic and medical constraints, many children receive treatment only in the metaphase and advanced clinical stages, resulting in high rates of blindness and disability. Although several approaches exist in the treatment of RB, some children with the disease do not have satisfactory results because of various factors. Plant-derived natural products have shown definite therapeutic effects in the treatment of various tumors and are also widely used in the study of RB. We review plant-derived natural products used in the study of anti-RB to provide ideas for the clinical application of these drugs and the development of new therapeutic drugs.
Os impactos da implantação repentina da Educação a Distância em meio à Pandemia da Covid-19
Authors: Martins Neto Rafael Izidoro , Leite Aline Chaves , Palacios Ingrid Rezende Silva , Souto Humberto Elias Giannecchini Fernandes Rocha
Published: July 2022

O presente artigo teve como objetivo analisar os impactos causados pela implantação do ensino a distância (EAD) em meio à pandemia do Covid-19, através da percepção de alunos do Centro-Oeste mineiro, comparando os diferentes níveis de ensino (médio, superior e pós-graduação) e a visão dos estudantes sobre as ações e medidas tomadas tanto pelas suas respectivas instituições acadêmicas, quanto pelo governo brasileiro. A pesquisa busca também verificar as opiniões dos discentes em relação ao impacto causado pelo (EAD) nos estudantes de baixa renda e a expectativa em relação à quando e como serão restabelecidos o ensino presencial e os processos de seleção do ensino médio. A fundamentação teórica envolveu temas como educação e tecnologia. O processo metodológico adotado, consistiu-se em uma pesquisa qualitativa. A coleta de dados ocorreu através da aplicação de um questionário estruturado, por meio de uma plataforma digital, aos sujeitos da pesquisa. Posteriormente, foi feito o tratamento, classificação e organização dos dados. Os resultados parciais mostraram que a maioria dos respondentes não foram contemplados com a implementação do ensino não presencial. Constatou-se ainda, que uma parcela bem pequena dos questionados consideraram que as medidas adotadas pelo governo federal foram suficientes para que os discentes não fossem prejudicados nesse cenário. Confirmou-se que, para os alunos de baixa renda os desafios deste momento serão ainda mais difíceis de serem superados. Conclui-se que o Brasil não está preparado para oferecer condições e suportes necessário para a implementação repentina do ensino a distância.
Avaliação dos cursos do Sistema Universidade Aberta do Brasil sob a perspectiva dos estudantes
Authors: Junior Armando Araujo de Souza , Nogueira Ricardo Jorge da Cunha Costa , Dutra Jurandir Moura , Rodrigues Joao Victor Figueiredo Cardoso
Published: July 2022

A Educação Pública a Distância vem se estabelecendo, nos últimos tempos, como uma alternativa efetiva para os desafios demandados pelos alunos de nível superior no Brasil. Esta modalidade vem conquistando mais apoio e se estabelecendo por meio de legislação específica e financiamento continuo por parte do Governo Federal. O objetivo geral desta pesquisa foi verificar a percepção dos estudantes sobre a qualidade dos cursos ofertados de forma a gerar um relatório descritivo, contendo o diagnóstico sobre os fatores internos e externos causadores, ou que poderiam causar desistências, e evasões. A pesquisa foi operacionalizada por meio da aplicação de um questionário utilizando-se a ferramenta LimeSurvey para 377.582 estudantes do Sistema Universidade Aberta do Brasil. Os resultados do estudo indicam uma avaliação satisfatória dos discentes em relação a modalidade, aos cursos ofertados e material didático disponibilizado. Por outro lado, o principal desafio dos discentes é conciliar os estudos com o trabalho. Os resultados possibilitam, sob um olhar diferenciado, o entendimento das percepções dos discentes da modalidade no âmbito da Universidade Aberta do Brasil.
Novel Method to Improve Heat Transfer Rate Through Delta Swirl Tape for a Swirl Jet Impingement Study
Authors: Gudi Abhay , Hindasageri Vijaykumar
Published: July 2022

With advancement of electronic equipment’s, there is a need to have an efficient method or mechanism that helps remove heat from the system. Air jet impingement is generally implied method for effective heat removal from these equipment’s. There are several types of air jet impingement techniques used and among them swirl air jet is one of most prominent and proven method. In this study, a novel method is proposed to improve heat transfer of a swirling air jet impingement. Experimental study has been performed with swirl tape and novel delta tape having twist ratio (T.R) = 2 for jet to plate distance of z/d=2 to 8 and Re varying between 1500 to 9000. This study is basically carried out to improve the heat transfer at low Re conditions. Thermal imaging technique is used to derive centerline Nu values for different jet to plate distances (z/d=2 to 8). Study shows that novel delta tape adds significant improvement in heat transfer for above mentioned conditions.
Effect of the Moving Wall to the Thermal and Dynamic Field in a Square Cavity with a Heat Source
Authors: Rachid Sahnoun , Habib Merouane , Ismail Drai
Published: July 2022

This study deals with convective heat transfer in a square cavity with a localized heat source at its center. The form factor of this configuration is (h/H=0.6) which is the ratio between the height of the source and the height of the cavity. The Rayleigh number is Ra=106 that indicated a laminar flow in this cavity. The numerical simulation gives a good result compared to the experimental data, which justifies the choice of our models used in this study. The objective is to make this natural convection a forced convection by the mobility of the upper wall. This made it possible to change the concentration of the state parameters in this cavity. This result can be used to make an orientation of the heat in this cavity. We note the use of four (4) speeds of the mobile wall in order to see the influence of the speed of this north wall on the convection phenomenon.
Improvement Potential and Sustainability Index of Photovoltaic Thermal Solar Air Collector
Authors: Zohri Muhammad , Ramadhan Wahyu , Fudholi Ahmad
Published: July 2022

Photovoltaic thermal (PVT) system is the future technology that will help in decreasing carbon emissions because this PVT technology generates electricity and thermal simultaneously. The advantage of PVT technology is that it is clean, saves space and cost, et cetera. This research applies an experimental approach in the laboratory and outdoors. The objective of this comparison is to generate real and controlled data and parameters. The analysis conducted is the improvement potential and sustainability index analysis. Both analyses are rarely conducted in PVT technology studies. Mass flow rate used was 0.01 kg/s-0.05 kg/s and sun intensity used was 800 W/m2. The result indicated the impact of mass flow rate on improvement potential and sustainability index. The higher the mass flow rate, the lower the improvement potential decreased; the higher the mass flow rate used, the higher the sustainability index increased.
Hydrodynamics of Reservoirs in Arid Areas and Its Influencing Factors
Authors: Qiao Ying , Gao Feng
Published: July 2022

Objective of this research is to accurately stimulate the hydrodynamic process in reservoirs thereby summarizing the hydrodynamics in reservoirs and figuring out its impact on the migration, conversion, and concentration of pollutants. For this purpose, this paper employed a 2D unstructured shallow water hydrodynamic model to perform numerical simulation on the flow field of the Yazidang Reservoir, one of the major reservoirs in the Ningxia Hui Autonomous Region of China; grids of shore boundaries in the model were densified to better fit the terrain changes at the boundaries, and the impact of wind field, and inflow/outflow on the flow field in the target reservoir was studied. The research findings suggest that, wind velocity has a great impact on the circulation intensity of the target reservoir, but it has no obvious impact on the circulation structure; the inflow and outflow have a certain impact on the area near the water inlet and outlet, and the range of this impact is related to the size of water volume of the inflow/outflow; under calm wind condition, the flow field of Yazidang Reservoir is entirely determined by the inflow and outflow, but the impact on the area far from the water inlet and outlet is very small, and wind field is one of the decisive factors for the flow field of Yazidang Reservoir. The research conclusions attained in this paper could provide useful theoretical evidences for the water ecological security of Yazidang Reservoir.
Feminity and Non Feminity in Ernest Gaines’ of Love and Dust
Authors: Kilanko Adièle Dr ZANNOU
Published: July 2022

Nowadays, sexual identity has become in hot issues. In social institutions, there debates about what should be the right attitudes to have toward queers and homosexuality. In literature, some characters are sometimes pictured as deviant, as persons who are questioning whether if they are men or women. In our article, we are using Ernest Gaines’s Of Love and Dust as a corpus and the tools of postmodernism and feminism to get insight in how the notions of feminity and Non feminity were viewed shortly, after the Emancipation period in the American Society, when African Americans were still living in the plantations.