bluuebunny/crossref_metadata_2025 huggingface dataset:
Polución hídrica en Madre de Dios: Una amenaza letal al bienestar humano y al equilibrio ambiental
Authors: Blanco Ayma Treysy Gabriela
Published: January 2025

El mundo enfrenta una etapa de crisis ambiental que impacta profundamente la vida de todos los seres que habitan este planeta, mientras que las autoridades se encuentran en gran medida sin soluciones efectivas para abordar este problema complejo y urgente. Este estudio tiene como objetivo identificar y analizar los factores que ponen en riesgo la calidad de los recursos naturales, especialmente el agua, el aire y los suelos, así como comprender el modo en que estos problemas afectan tanto a la salud humana como al equilibrio de los ecosistemas. Se concluye que, la contaminación es un fenómeno global impulsado por múltiples causas, entre las cuales las actividades humanas, la industrialización, el uso de combustibles fósiles y la deforestación. A ello se suma la respuesta insuficiente de las autoridades de la región y la falta de políticas eficaces para enfrentar esta situación, lo cual agrava el impacto sobre el medio ambiente y la calidad de vida de las futuras generaciones.
Dvě stě let Prodromu rostlinné systematiky
Authors: Neustupa Jiří
Published: January 2025

Two hundred years of Prodromus of plant systematics

The year 2024 marks the 200th anniversary of the commencement of the publishing of one of the most fundamental works of plant systematics, namely Prodromus Systematis Naturalis Regni Vegetabilis. The spiritual father and founder of this series was the Genevan botanist Augustin Pyramus de Candolle (1778–1841). The present study briefly examines his intellectual development and his relationships with Jean-Baptiste Lamarck (1744–1829). It also discusses the concept of a “natural system” in De Candolle’s conception. It then examines the process of publishing the successive volumes of Prodromus, especially after the leadership of the series was taken over by Augustin’s son, Alphonse Louis Pierre Pyramus de Candolle (1806–1893), and eventually by his grandson, Anne Casimir Pyramus de Candolle (1836–1918).
Chemie na Přírodovědecké fakultě Německé univerzity v Praze 1920–1945
Authors: Pešek Jiří , Lohmann Nina , Šaman David
Published: January 2025

Chemistry at the Faculty of Sciences of the German University in Prague in 1920–1945

Chemistry was established at the University of Prague – mainly in connection with medicine - already in the 19th century. In the interwar period, the German University in Prague had two chemical institutes: the large general Institute for Chemistry and the smaller, younger Institute for Physical Chemistry.
This study traces their internal development, the topics of their dissertations and their personnel. Special attention is paid to the key figures of both institutes in the period under review: the organicists Hans Meyer and Ernst Waldschmidt-Leitz, and the physical chemists Viktor Rothmund and Johann Böhm.
„V Ghaně jsem strávil nejhezčí léta svého života“: Afrika Jana Krekuleho
Authors: Hermann Tomáš , Joseph Jacques , Krekule Jan
Published: January 2025

“I spent the best years of my life in Ghana”: Africa by Jan Krekule

Plant physiologist Jan Krekule (1931-2022) worked as a researcher at the Cocoa Research Institute in Ghana from 1966 to 1968 under the agreement between the Czechoslovak and Ghanaian Academies of Sciences at the time. He joined as Head of the Department of Plant Physiology and, in this position, he proposed and subsequently implemented two new topics: hormonal regulation of premature dropping of young cocoa fruits (cherelle wilting) and the effect of direct sunlight on the growth of cocoa plants. He therefore sought ways to promote the fertility of cocoa trees by applying plant hormones and to optimise seedling production. Tomáš Hermann and Jacques Joseph conducted a memorial interview with Jan Krekule shortly before his death about the research, as well as the cultural and social context of his fellowship in Ghana.
HUBUNGAN PENGETAHUAN IBU DENGAN PEMBERIANASI EKSKLUSIF DI WILAYAH KERJAPUSKESMAS KAWANGKOAN
Authors: Tampi Anggriani , Timmerman Ellen , Walanda Irwan
Published: January 2025

ASI merupakan makanan terbaik buat bayi. asupan ASI yang kurang mengakibatkan kebutuhan gizi bayi menjadi tidak seimbang. ketidakseimbangan pemenuhan gizi pada bayi akan berdampak buruk pada kualitas sumber daya manusia yang dapat dilihat dari terhambatnya tumbuh kembang bayi secara optimal pemberian asi pada bayi merupakan cara terbaik meningkatkan kualitas sumber daya manusia sejak dini. Tujuan penelitian untuk mengetahui hubungan pengetahuan ibu dengan pemberian asi eksklusif di wilayah kerja Puskesmas Kawangkoan. Metode penelitian kuantitatif ini menggunakan pendekatan cross-sectional. sampel dalam penelitian ini semua ibu yang mempunyai bayi usia 6-12 bulan yang berjumlah 71 orang. menggunakan teknik sampling secara total sampling. Teknik analisa data menggunakan univariat dan bivariat menggunakan uji statistik spearman rho. Hasil penelitian terdapat hubungan yang signifikan (p=0.001) pengetahuan ibu dan pemberian asi eksklusif di wilayah kerja Puskesmas Kawangkoan dengan koefisien korelasi cukup kuat dan arah hubungan variabel yaitu negative (-0.507). Kesimpulan terdapat hubungan bermakna antara pengetahuan ibu dengan pemberian asi eksklusif di wilayah kerja Puskesmas Kawangkoan.
Gestão Inovadora e Desafios Empresariais: Estratégias de Sucesso para o Crescimento e Sustentabilidade Corporativa
Authors:   Editora Revista Dominio Cientifico, Braga Lima Agnaldo , Oliveira Ramos Magno , Magalhães Reginaldo , Almeida Bezerra Daniel , Rachel Arguello Leandro , Santos de Freitas Denílson , Ribamar Santos Moraes Filho José , do Socorro Ferreira Cavalcante Lima Odaize
Published: January 2025

“Gestão Inovadora e Desafios Empresariais: Estratégias de Sucesso para o Crescimento e Sustentabilidade Corporativa” apresenta uma análise abrangente dos principais temas que moldam a administração contemporânea. Em um ambiente empresarial em constante transformação, marcado por inovações tecnológicas, desafios econômicos e exigências por sustentabilidade, este eBook oferece insights e estratégias para capacitar líderes, gestores e empreendedores.
Organizado em capítulos temáticos, o eBook explora questões cruciais, como o papel da gestão de pessoas na implementação de inovações tecnológicas, abordagens para análise de riscos em projetos e o uso da inteligência competitiva na formulação de estratégias empresariais. Além disso, destaca práticas de governança corporativa integradas à sustentabilidade, estratégias de liderança resiliente em tempos de crise, e transformação digital para empresas que desejam competir no mercado global.
Com foco na inclusão e na valorização do capital humano, o material também discute a relevância da diversidade no ambiente corporativo e a importância de modelos de negócios sustentáveis para a criação de valor em mercados competitivos. Capítulos adicionais abordam o impacto do marketing verde no posicionamento de marcas e o papel do empreendedorismo corporativo na promoção da inovação e do crescimento sustentável.
Este eBook é um guia essencial para profissionais que buscam desenvolver competências estratégicas e inovadoras, promovendo uma gestão ética, inclusiva e preparada para os desafios do futuro.

Coleção Administração 4.0 - Editora Revista Domínio Científico - www.editoradominiocientifico.org

"O Papel da Gestão de Pessoas na Implementação de Inovações Tecnológicas: Desafios e Estratégias em Grandes Organizações" "Análise de Riscos e Tomada de Decisão em Projetos: Abordagens de Gestão de Riscos nas Empresas do Setor de Tecnologia"
"A Importância da Inteligência Competitiva na Formulação de Estratégias Empresariais: Estudo de Caso em Empresas Multinacionais"
"Governança Corporativa e Sustentabilidade: Integrando Práticas Éticas e Responsabilidade Social Empresarial"
"Transformação Digital e Gestão da Inovação: Como Empresas Tradicionais Podem Competir no Mercado Digital"
"Estratégias de Liderança em Tempos de Crise: Lições de Resiliência para Gestores Empresariais"
"Modelos de Negócios Sustentáveis: Inovação e Criação de Valor em Mercados Competitivos"
"Gestão de Recursos Humanos e Diversidade: Estratégias para Inclusão e Valorização do Capital Humano"
"O Papel do Marketing Verde no Posicionamento de Marcas: Estratégias Sustentáveis para Ganhar Vantagem Competitiva" "Empreendedorismo Corporativo e Sustentabilidade: Iniciativas Internas para Fomentar a Inovação e o Crescimento Sustentável"
Tuberculose multifocale avec localisation rare chez une patiente immunocompétente
Authors:   Département de médecine interne, CHU Ibn Rochd, Casablanca, Maroc, Lassouli Israa , Moudatir Mina , Echchilali Khadija , El Kabli Hassan
Published: January 2025

Une résurgence de la tuberculose notamment au profit des formes extra pulmonaires est signalée depuis une dizaine d’années dans les pays du Maghreb.
Les formes multifocales surviennent habituellement chez des sujets immunodéprimés.
Bien que le diagnostic puisse être orienté par des radiographies, l'examen bactériologique et histologique des tissus permet l'isolement du pathogène, l'identification du bacille et la détermination de la sensibilité de la souche au traitement anti bacillaire.
Les localisations rares et inhabituelles de la tuberculose ostéoarticulaire posent souvent un problème de diagnostic pour le clinicien. Tout tableau clinique traînant ou toute lésion osseuse suspecte et de présentation atypique doit faire évoquer le diagnostic de tuberculose dans notre contexte.
Effect Of Emotional Intelligence And Intelligence Intrapersonal On Learning Outcomes Mathematics Of Class Ii Students Of SD Inpres Makassar
Authors: Haryono Patrisius
Published: January 2025

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kecerdasan emosional dan kecerdasan intrapersonal terhadap hasil belajar matematika siswa kelas Inpres Makassar. Populasi dari penelitian ini adalah seluruh siswa kelas  di SD Inpres Makassar dengan sampel sebanyak 28 siswa. Penelitian ini menggunakan penelitian analisis deskriptif dan analisis inferensial. Dari hasil pengolahan data terlihat bahwa: (1) terdapat pengaruh yang signifikan dari kecerdasan emosional () terhadap hasil belajar matematika (Y) dengan  = 183,637 > = 3,37; (2) terdapat pengaruh yang signifikan dari kecerdasan intrapersonal () terhadap hasil belajar matematika (Y) dengan = 258,415 > = 3,37; dan (3) terdapat pengaruh signifikan antara kecerdasan emosional (), kecerdasan intrapersonal () terhadap hasil belajar matematika (Y) dengan = 55,516 > = 3,37. Dapat disimpulkan bahwa  ditolak dan terdapat pengaruh yang signifikan dari kecerdasan emosional dankecerdasan intrapersonal secara bersama-sama terhadap hasil belajar matematika.
(Un)truth Will Set You Free: The importance of deception within criminal law
Authors: Driscoll Elisabeth G
Published: January 2025

Deception’s role within criminal law is rarely discussed, yet it underpins the vast majority of the criminal trial process. As our system is adversarial, two contradicting versions of events may be presented to the court, meaning one side is in some way attempting to deceive the court (whether directly or through exaggeration of their certainty regarding the facts). Of course, some cases are disputes over the word of the law, however, this is not the case in all. In such cases, either a claimant has brought a false accusation against a defendant or the defendant, who may have been urged to deceive the court by pleading not guilty in the name of their own right to a fair trial, is offering a false defence. A barrister’s role in such circumstances is effectively to present their client as undoubtedly innocent and correct in their version of events and to undermine the other party’s case, and through this one or both is likely to be misleading the court. Most of the time someone is deceiving the court. The law only seems to care about direct lying which is prohibited under perjury legislation. Other forms of deception are regarded as due process, a test of the burden of proof. Although this article agrees with this, it is interesting to explore the legal and moral differentiation between these different types of deception and the fact that we allow, and embrace, some forms should not remain unmarked.
HAMBATAN GURU DALAM IMPLEMENTASI KURIKULUM MERDEKA DI KABUPATEN BIREUEN
Authors: Mizwar Edi , Jarjani Usman  , Sri Suyanta
Published: January 2025

This research aims to identify the obstacles faced by teachers in implementing the independent curriculum in Bireuen Regency. The approach used in this research is a qualitative approach. The research method employed in this study is a survey method, where information is collected from respondents using a questionnaire through Google Forms. The data collected in this study is sourced from Islamic Education teachers (PAI) at the elementary (SD/MI), junior high (SMP/MTs), and senior high (SMA/MA) levels in Bireuen Regency. The data analysis technique used in this research is a descriptive method. Based on the results of the conducted research, it was found that the obstacles faced by teachers in Bireuen Regency in the implementation of the independent curriculum include a lack of experience with independent learning, limited references, access constraints in teaching, time management, inadequate competencies (skills), mindset changes, insufficient support and training, as well as evaluation and assessment issues
Handling Cases of Bullying Practices in The School Environment in Terms of Criminal Law
Authors: Dores Dedi , Mubarok M. Khusni , Setiawan Hery , Kumala Milka , Khilmi Muhammad
Published: January 2025

This research aims to find out what are the backgrounds of bulliying, law enforcement for perpetrators, protection for victims and how to find solutions so that bulliying cases do not mushroom in places that should be a place of knowledge. The research method used is normative research method using regulatory approach. Legal protection for victims of bullying crimes is regulated in Article 76C of the Child Protection Law No. 35 of 2014. This article contains content that prohibits violence against children. Legal protection against the perpetrators of bullying, where the perpetrator also has rights that are his rights, protection can be achieved by prioritizing differences in efforts to overcome the problem of bullying and by overriding criminal penalties, if diversion does not find an agreement, then specifically the perpetrators of child crimes are tried taking into account the principles contained in Law Number 11 of 2012 concerning the Juvenile Justice System. Crime prevention efforts can be divided into penal prevention (criminal law) and non eanal prevention (other than criminal law).
The Problem of Illicit Gold Mining from The Standpoint of a State Upholding The Rule of Law
Authors: Tries Edy Wahyono  , Mochtar Mochammad , Soediono Ricardo , Emilia  , Romli Mustain
Published: January 2025

The three primary questions this research seeks to address are: How does criminal law approach environmental issues, such the PETI case, and what are the ethical philosophy of preventative initiatives' perspectives on solving environmental issues? as well as the measures taken by the government to address this issue. This paper uses a qualitative research methodology that is somewhat juridical-empirical in character. Written resources (books, journals, papers, etc.) are the source of data for this topic. This research study divides textual material into two categories: main and secondary. Criminal threats, such as jail time and fines, must exist for PETI offenders, as mentioned in the articles. Further criminal or disciplinary penalties under Article 119 Law Number 32 of 2009 concerning Environmental Protection and Management can be imposed on commercial companies. People need to understand their own roles, obligations, and responsibilities in life. in order for this moral idea to serve as a safeguard against human-caused environmental harm. Lastly, in regards to the government policies that also need to play a role in solving this PETI issue, these include: offering support to enable PETI to become a legal business; offering technical help; offering financial support for development; and offering access to prevent business actors from feeling pressured to legalize a business. the mining.
Complications of Sub-Retinal Fluid Drainage in Scleral Buckling
Authors: Jan Sanaullah , Muhammad Zia ud din Khalil  , Shahnam Tariq , Ashfaq ur Rahman
Published: January 2025

Objective: To determine safety and efficacy of sub-retinal fluid drainage by cut down technique in sclera buckling surgery.
Study Design: A prospective interventional case series.
Duration and setting of study: This study was performed at department of ophthalmology, Hayatabad Medical Complex, Peshawar, Pakistan from March, 2019 to September, 2019.
Methods: All patients with rhegmatogenous retinal detachment, who were admitted in department ofophthalmology and were due for scleral buckling surgery were included in this study. All cases were operated by a single surgeon (S J) and in all cases sub-retinal fluid was drained by cut down technique (Incisional sclerochoroidotomy). A predesigned proforma was completed for every study case recording preoperative characteristics and intra-operative complications. Post operative retina status and fundus findings were also noted. SPSS version 21 was used for data analysis.
Results: A total of 53 eyes were included in the study. Mean age of the patients was 39 years. Male were 77.4 and female were 22.6%. Proliferative vitreo retinopathy was grade A in 34%, grade B in 64% and grade C in 2% of eyes. Macula was attached in 18.9% of eyes and was detached in 81.1% of cases. No complications were found in 11.3% eyes. The most common intra-operative complication was sub-retinal bleed (9.4%). .
Conclusions: Sub-retinal fluid drainage by cut down technique is relatively safe. The most common complication of SRF drainage is sub-retinal bleed.
Comparison of Contrast Sensitivity in Subjects Wearing Spectacles and Contact Lenses
Authors: Mujeeb Ur Rehman  , Palwasha
Published: January 2025

Aims: The purpose of this study was to compare the contrast sensitivity level in people wearing soft contact lenses and spectacles.
Study design: Cross sectional
Duration and Study Setting: Six months, Ophthalmology Department, Hayatabad Medical Complex, Peshawar.
Methods: Data were taken from participants having myopic refractive error only, wearing soft contact lenses and spectacles for correction of their myopia. All the participants underwent comprehensive eye examination. Contrast Sensitivity (CS) were measured with Lea contrast sensitivity chart for each eye separately at three meters, two meters and one meter distances with spectacles first and then with soft contact lenses. After complete assessment, mean change in CS in contact lenses and spectacles were compared with paired t-test using SPSS 17.0.
Results: A total of 48 eyes were tested. The mean age of subjects was 22 ±1.45. Contrast sensitivity Mean in spectacle was 78 at 3m, 127 at 2m, and 160 at 1m. CS Mean in contact lens is 65 at 3m, 117 at 2m, and 156 at 1m. Paired T test (two tailed) for means and alpha 0.05 was applied and showed the results were insignificant at 3m with p= 0.095, at 2m p=0.185 and at 1m p=0.327. The higher mean change in CS was observed in the age group of 23 years and moderate myopia.
Conclusion: There was no statistically significant difference in CS between spectacle and soft contact lens wearing at three, two and one meter. According to our results there is no preference for contact lenses and spectacles regarding contrast.
Unveiling The Angiogenic Paradigm: The Angiogenesis Revolution Transforming Cancer Treatment Landscapes Through VEGF Inhibition
Authors: Saladi Saisri Ram  , Naidu Yasnasri Subharao
Published: January 2025

Angiogenesis, the formation of new blood vessels, is a critical process in the progression of cancer. Extensive research has identified Vascular Endothelial Growth Factor (VEGF) as a primary regulator of this process, particularly in promoting sprouting angiogenesis. Inhibiting VEGF has been shown to suppress tumour growth in animal models, which has spurred the development of anti-angiogenic therapies aimed at blocking the vascular supply to tumors, thereby depriving them of essential nutrients and oxygen. Currently, around 11 anti-VEGF drugs have received approval for use in specific advanced cancers, either as standalone treatments or in combination with chemotherapy and other targeted therapies. Despite these advances, VEGF inhibition does not prove effective in all cancer types, and the impact of anti-angiogenic therapies on overall survival rates remains limited in many cases. This review discusses the present status of FDA-approved anti-angiogenic drugs, including antibodies and Tyrosine Kinase Inhibitors, and provides insights into the progress and future prospects of VEGF-targeted therapies.
Protestens evindelige genkomst?
Authors: Fabricius Charlotte J.
Published: January 2025

“The Eternal Return of the Protest? Feminist Poster Art, Reimagined”
The article discusses the place of historical feminist posters, especially from the 1970s, in contemporaryfeminism. By analysing the temporalities, af- fects, and materiality of a recent book of feminist poster art, Ican’t believe I still have to protest this shit (edited by Jessica Hallbäck, Gutkind 2023), the article argues for thesuitability of a transhistorical approach when making use of past pro- test art in the age of digital-first feminism.
Czy ubezpieczonemu przysługuje status konsumenta w świetle przepisów kodeksu cywilnego?
Authors:   Katedra Prawa Gospodarczego i Handlowego, Wydział Prawa i Administracji, Uniwersytet Łódzki, Ulański Jan
Published: January 2025

W umowie ubezpieczenia na cudzy rachunek, obok ubezpieczającego i ubezpieczyciela pojawia się ubezpieczony, który nie jest stroną umowy ubezpieczenia, jednak to jego interes ubezpieczeniowy podlega ochronie z niej wynikającej. Jednocześnie ubezpieczony, którym często jest osoba fizyczna, jest niewątpliwie słabszym podmiotem tak ukształtowanego stosunku ubezpieczenia i powinna obejmować go ochrona konsumencka analogiczna do przysługującej w typowej umowie ubezpieczenia ubezpieczającemu będącemu konsumentem. Z uwagi jednak na to, że ubezpieczony nie jest stroną umowy ubezpieczenia, pojawiają się wątpliwości czy w świetle regulacji przyjętej w polskim kodeksie cywilnym przysługuje mu status konsumenta. Niniejszy artykuł stara się odpowiedzieć na tak postawione pytanie, w głównej mierze opierając się na przyjętych w judykaturze propozycjach i rozwiązaniach.
Défis et opportunités d’une université francophone dans un milieu non francophone : l’exemple de Galatasaray
Authors: Bilener Tolga
Published: January 2025

Fruit de la coopération franco-turque, l’Université Galatasaray, établie en 1992, est l’unique institution francophone d’enseignement supérieur en Turquie, pays non francophone. En s’appuyant sur la tradition de modernisation du pays qui s’effectua à travers le français entre le 19e siècle et la première moitié du 20e, l’institution reflète, d’une part, la volonté de préserver une tradition d’occidentalisation identifiée à une certaine élite inspirée des idées des Lumières, et d’autre part, la diplomatie culturelle de la France qui souhaite avoir des interlocuteurs francophones dans un pays avec lequel elle entretient des relations diplomatiques pluriséculaires, des liens commerciaux importants, sans oublier son importance géopolitique. L’expérience de cette université dont l’ambition est de devenir un pôle d’excellence dans son domaine montre à la fois les avantages et les inconvénients d’une université francophone de petite taille dans un environnement non francophone, tout en rappelant son rôle en tant qu’instrument de diplomatie culturelle.
Ética y privacidad en la era digital desde la perspectiva de la creación de espacios seguros. Arte, tecnología y ética
Authors: Garzo Camón Tiffany
Published: January 2025

Para abordar el impacto de la tecnología y las nuevas eras digitales en la esfera doméstica, debemos hablar también de las cuestiones relacionadas con los usos éticos de esta y su condicionamiento a la privacidad. La transformación en las interacciones con nuestros hogares se pone en el punto de mira ante esta hiperexhibición dada desde el desarrollo de la fotografía hasta los mass media y los social media. La intimidad y lo público se contraponen tras una continua invasión a lo privado, produciendo una fatiga digital constante. El arte mediático podría servir como apoyo en cuanto a cómo este ha reflejado y cuestionado estas transformaciones ofreciendo nuevas perspectivas y lecturas que versan sobre la (des)conexión humana en un mundo digitalizado. Debemos subrayar la importancia, cada vez más latente, de abordar problemas éticos y de privacidad en el uso de las tecnologías domésticas, así como de promover la reflexión crítica sobre el uso de las redes sociales y la preservación de la identidad digital mediante la implementación de regulaciones urgentes.
El asombro tecnológico en el videojuego
Authors: Rodrigo de Haro Miguel
Published: January 2025

El desarrollo tecnológico ha tenido un papel de gran relevancia en la evolución del videojuego. En torno a este se suelen vertebrar los grandes paradigmas de la historia del medio, ya que posibilita el desarrollo de nuevos procedimientos narrativos y mecánicos, así como nuevos estilos visuales. No obstante, limitarnos al análisis tecnológico para encasillar una génesis en la novedad de los videojuegos de cada época no permite comprender su evolución como arte con unos objetivos estéticos concretos. La tecnología sirve como herramienta novedosa y con gran potencial para la finalidad estética del videojuego, pero para ello se ha de producir una deformación perceptiva que provoque un verdadero cambio en la visión del medio. En este trabajo se parte de una reformulación del concepto de asombro y de la teoría de la desautomatización de Shklovski con el objetivo de desarrollar una teoría sobre el papel de la tecnología en el cambio y la estética. Para ello, se hará la distinción entre técnica y tecnología, para precisar los distintos medios creativos de los que hace uso el videojuego con objetivos artísticos. Se propone el concepto de asombro tecnológico como herramienta metodológica para identificar usos estéticos de carácter extraordinario de la tecnología.
Um metódico à brasileira: a História da historiografia de Afonso de Taunay (1911-1939)
Authors: Anhezini Karina
Published: January 2025

A historiografia brasileira, de forma geral, tem negligenciado a real abrangência das documentações propostas e analisadas por Afonso de Taunay. Neste livro, Karina Anhezini preenche essa significativa lacuna: recupera aquela documentação, localiza e critica os usos dados das infor­mações e nos oferece uma obra abrangente e pertinente aos modelos analíticos desenvolvidos pela historiografia moderna. De forma competente, a autora demonstra como a historiografia desenvolvida por Taunay tinha caráter laudatório e épico – elementos fundamentais para a compreesão da história escrita no Brasil no final do século XIX e nas primeira décadas do século XX – e tece um fio narrati­vo que navega por inúmeras fontes literárias, sem, contudo, perder a pre­cisão e o detalhamento histórico. Ao recuperar os escritos e o modelo metodológico de análise desenvolvido por Taunay, trilhando pelo modelo de intelectualidade existente naquele período, a autora abre novos cami­nhos para a percepção das obras e do pensamento desse historiador. Um livro importante, que certamente garante a continuidade e a atualização dos debates sobre a historiografia brasileira na atualidade.
Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration
Authors: Chen Cong , Gao Tong-Yao , Yi Hua-Wei , Zhang Yi , Wang Tong , Lou Zhi-Lin , Wei Tao-Feng , Lu Yun-Bi , Li Ting-Ting , Tang Chun , Zhang Wei-Ping
Published: January 2025

Ubiquitin (Ub), a key player of protein turnover, can be phosphorylated by PINK1 kinase to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and human brains with Parkinson’s disease. However, how pUb is involved in neurodegeneration remains elusive. Here we show that elevation of pUb is pervasive in a multitude of neurodegenerative conditions, including Alzheimer’s disease, aging, and ischemic injury. In cultured cells, proteasomal inhibition by MG132 leads to sPINK1 accumulation, the cytosolic fragment of PINK1, thus promoting Ub phosphorylation. Elevated pUb impairs proteasomal degradation by disrupting covalent ubiquitin chain elongation and noncovalent proteasome-substrate interaction. Conversely,
pink1
knockout mitigates protein aggregation in both aging and ischemic mouse brains, as well as cells treated with MG132. Using AAV2/9 vector to specifically express sPINK1 in mouse hippocampus neurons, we observed cumulative pUb elevation, accompanied by protein aggregation, proteostasis disturbance, neuronal injury, neuroinflammation, and cognitive impairment. These sPINK1-induced impairments were reversed by co-expressing Ub/S65A phospho-null Ub mutant but exacerbated by Ub/S65E phospho-mimic mutant. As such, pUb elevation can result from declined proteasomal activity in neurodegenerative conditions, while a constant elevation of pUb actively drives neurodegeneration by further inhibiting proteasomal degradation. Our study reveals a new pathogenic pathway of neurodegeneration, highlighting the pUb-mediated feedforward loop as a promising therapeutic target for pharmaceutical intervention.
Prediction and Optimization of Process Parameters using Artificial Intelligence and Machine Learning Models
Authors: Bbumba Simon , Kigozi Moses , Karume Ibrahim , Arum Chinaecherem Tochukwu , Murungi Moses , Babirye Prudence Mary , Kirabo Solome
Published: January 2025

Herein we reviewed Artificial intelligence (AI) and Machine learning (ML) models in the prediction and optimization of process parameters during the removal of toxic heavy metals and textile dyes. Parameters normally optimized include pH, contact time, initial concentration, adsorbent dosage, and temperature.  This review focuses on common AI models such as Artificial Neural Networks (ANN), Particle Swarm Optimization, and Genetic Algorithms (GA). Furthermore, the review describes the common prediction statistical indicators such as coefficient of determination (R2), root mean square error (RMSE), mean squared error (MSE), absolute average deviation (AAD), etc. Lastly, this review highlights the significant potential of AI and ML in revolutionizing the field of wastewater treatment and mitigating the environmental impact of industrial pollution.
The Dead Internet Theory: A Survey on Artificial Interactions and the Future of Social Media
Authors: Muzumdar Prathamesh , Cheemalapati Sumanth , RamiReddy Srikanth Reddy , Singh Kuldeep , Kurian George , Muley Apoorva
Published: January 2025

The Dead Internet Theory (DIT) suggests that much of today’s internet, particularly social media, is dominated by non-human activity, AI-generated content, and corporate agendas, leading to a decline in authentic human interaction. This study explores the origins, core claims, and implications of DIT, emphasizing its relevance in the context of social media platforms. The theory emerged as a response to the perceived homogenization of online spaces, highlighting issues like the proliferation of bots, algorithmically generated content, and the prioritization of engagement metrics over genuine user interaction. AI technologies play a central role in this phenomenon, as social media platforms increasingly use algorithms and machine learning to curate content, drive engagement, and maximize advertising revenue. While these tools enhance scalability and personalization, they also prioritize virality and consumption over authentic communication, contributing to the erosion of trust, the loss of content diversity, and a dehumanized internet experience. This study redefines DIT in the context of social media, proposing that the commodification of content consumption for revenue has taken precedence over meaningful human connectivity. By focusing on engagement metrics, platforms foster a sense of artificiality and disconnection, underscoring the need for human-centric approaches to revive authentic online interaction and community building.
Antimicrobial Resistance and Virulence Factors of Staphylococcus aureus in Dairy Farms: Insights from the Animal-Human-Environment Interface
Authors: Hinge G. R. , Waskar V.S. , Kolhe R.P. , Bhong C.D. , Shende T.C. , Sudrik Snehal , Gadhave Snehal
Published: January 2025

In India, dairy farming is run by medium, small, and landless farmers and has a stable biotope at the animal-human-environment interface. Hence a cross-sectional study was conducted for the detection of antimicrobial resistance in targeting indicator bacteria Staphylococcus aureus at the animal-human-environment interface. A total of 280 samples were collected from dairy farms and their environment. The highest prevalence was noticed in human sources (50%), followed by animal sources (28.50%), dairy equipment (27.50%), and the lowest in farm environments (20.83%), and the overall prevalence noted was 27.85%. The prevalence of species-specific sau gene for S. aureus was 80.76%. Virulence-associated genes viz. sea and seb were detected in 7.93% and 9.52% isolates of S. aureus. The thermostable nuclease nuc gene was found in isolates from animal and human sources with an overall prevalence of 41.26%. Overall antimicrobial resistance pattern of S. aureus isolated from dairy farm and its environment was in the descending order i.e., highest for cefoxitin, erythromycin, amikacin, and clindamycin; moderate resistance was seen in vancomycin and streptomycin, linezolid and tetracycline and the lowest resistance was observed in chloramphenicol, gentamicin, and amoxicillin-clavulanic acid irrespective of the source. In the present study, the prevalence of tetM was 20% (2/10) in farm environments, 1.75% (1/57) dairy animals, and 33.33% (1/3) in dairy equipment with an overall prevalence of 5.19%.
Impact of Integrated Interventions of Prescriber Education and De-escalation Strategies on Implementing WHO Access: Insights from a South Indian Tertiary Care Setting
Authors: Martinraj Jasper Victoria Leelarani , S Harini. , Bibila S. , Thomas Feba Mary , George Keren Ann
Published: January 2025

Aims: This study evaluates the effect of integrated interventions including prescriber education and de-escalation strategies on improving antibiotic prescribing practices, optimizing the Access: Watch ratio, reducing Reserve antibiotic use, and improving Length of Therapy (LOT) adherence in a South Indian tertiary care hospital.
Study Design: Prospective Observational Study.
Place and Duration of Study: The study was carried out in Fortis Healthcare, Adyar for a period of five months (March to July 2023).
Methodology: Data on Days of Therapy (DOT) and LOT were collected. Prescriber education and audit interventions were implemented, with pre- and post-intervention surveys to assess prescriber confidence in de-escalation.
Results: The Access: Watch ratio improved from 0.45 to 0.52, with a marked reduction in Watch antibiotic consumption. DOT for Cefoperazone-Sulbactam, a Watch antibiotic, decreased from 50.7 to 18.1, and Reserve antibiotics (e.g., Linezolid and Colistin) showed significant reductions. LOT adherence to WHO guidelines improved for various infections, and prescriber confidence in de-escalation increased from 88.9% to 100%.
Conclusion: Integrated interventions significantly optimized antibiotic use, achieved WHO Access: Watch targets, reduced Reserve antibiotic use, and enhanced prescriber practices. The study demonstrates the potential for similar strategies in other resource-limited settings to combat AMR.
Maximizing Ethylene Production Yield by Modifying the Methanol to Olefin Process with the Addition of a Distillation Tower
Authors: Sitio Arnanda R.H , Azahra Dini Salwa , Zahrani Fatimah Nur , Martantri Reyna Zahwa Muji , Ajitira Sendy Nanda
Published: January 2025

Ethylene is a feedstock that produces polyethene and other industrial chemicals such as ethylene oxide. The methanol-to-olefins process is a technology designed to transform methanol into light olefins like ethylene and propylene, which are crucial raw materials in the petrochemical industry. The first reaction involves the production of dimethyl ether and water from methanol. The second reaction consists of the conversion of dimethyl ether to ethylene and water. This paper will explain how to maximize ethylene production yield by modifying the methanol to olefin process. The process modification was carried out by adding a distillation tower. Based on process modifications increased the ethylene quantity from 21,070 tons/year to 179,400 tons/year. The case study results indicate an increasing yield of the product exiting. Copyright © 2024 by Authors, Published by Universitas Diponegoro and BCREC Publishing Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Intravenous Immunoglobulin and Dermatomyositis-Associated Venous Thromboembolism
Authors: Rotrosen Elizabeth T. , Zahedi Niaki Omid , Kassamali Bina , Lonowski Sarah , Shahriari Neda , LaChance Avery , Vleugels Ruth Ann
Published: May 2023

This cohort study investigated the association between treatment of dermatomyositis with intravenous immunoglobulin and thromboembolic events.
Perspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs
Authors: Sue Kimberly L. , Chawarski Marek , Curry Leslie , McNeil Ryan , Coupet Edouard , Schwartz Robert P. , Wilder Christine , Tsui Judith I. , Hawk Kathryn F. , D’Onofrio Gail , O’Connor Patrick G. , Fiellin David A. , Edelman E. Jennifer
Published: May 2023

Importance

An increasing number of emergency departments (EDs) are initiating buprenorphine for opioid use disorder (OUD) and linking patients to ongoing community-based treatment, yet community-based clinician and staff perspectives regarding this practice have not been characterized.

Objective

To explore perspectives and experiences regarding ED-initiated buprenorphine among community-based clinicians and staff in geographically distinct regions.

Design, Setting, and Participants

This qualitative study reports findings from Project ED Health, a hybrid type 3 effectiveness-implementation study designed to evaluate the impact of implementation facilitation on ED-initiated buprenorphine with referral to ongoing medication treatment. Clinicians and staff from community-based treatment programs were identified by urban academic EDs as potential referral sites for ongoing OUD treatment in 4 cities across the US in a formative evaluation as having the capability to continue medication treatment. Focus groups were held from April 1, 2018, to January 11, 2019, to examine community OUD treatment clinician and staff perspectives on accepting patients who have received ED-initiated buprenorphine. Data were analyzed from August 2020 to August 2022.

Main Outcomes and Measures

Data collection and analysis were grounded in the Promoting Action on Research Implementation in Health Services (PARIHS) implementation science framework, focusing on domains including evidence, context, and facilitation.

Results

A total of 103 individuals (mean [SD] age, 45.3 [12.0] years; 76 female and 64 White) participated in 14 focus groups (groups ranged from 3-22 participants). Participants shared negative attitudes toward buprenorphine and variable attitudes toward ED-initiated buprenorphine. Prominent barriers included the community site treatment capacity and structure as well as payment and regulatory barriers. Perceived factors that could facilitate this model included additional substance use disorder training for ED staff, referrals and communication, greater inclusion of peer navigators, and addressing sociostructural marginalization that patients faced.

Conclusions and Relevance

In this study of community-based clinicians and staff positioned to deliver OUD treatment, participants reported many barriers to successful linkages for patients who received ED-initiated buprenorphine. Strategies to improve these linkages included educating communities and programs, modeling low-barrier philosophies, and using additional staff trained in addiction as resources to improve transitions from EDs to community partners.
Intimate Partner Violence Circumstances for Fatal Violence in the US
Authors: Kafka Julie M. , Moracco Kathryn E. , Graham Laurie M. , AbiNader Millan A. , Fliss Mike Dolan , Rowhani-Rahbar Ali
Published: May 2023

This cross-sectional study investigates intimate partner violence circumstances associated with violent deaths in the US from 2015 to 2019.
Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders
Authors: Jaholkowski Piotr , Shadrin Alexey A. , Jangmo Andreas , Frei Evgeniia , Tesfaye Markos , Hindley Guy F. L. , Haram Marit , Rahman Zillur , Athanasiu Lavinia , Bakken Nora Refsum , Holen Børge , Fominykh Vera , Kutrolli Gleda , Parekh Pravesh , Parker Nadine , Rødevand Linn , Birkenæs Viktoria , Djurovic Srdjan , Frei Oleksandr , O’Connell Kevin S. , Smeland Olav B. , Tesli Martin , Andreassen Ole A.
Published: May 2023

Importance

Premenstrual disorders are heritable, clinically heterogenous, with a range of affective spectrum comorbidities. It is unclear whether genetic predispositions to affective spectrum disorders or other major psychiatric disorders are associated with symptoms of premenstrual disorders.

Objective

To assesss whether symptoms of premenstrual disorders are associated with the genetic liability for major psychiatric disorders, as indexed by polygenic risk scores (PRSs).

Design, Setting, and Participants

Women from the Norwegian Mother, Father and Child Cohort Study were included in this genetic association study. PRSs were used to determine whether genetic liability for major depression, bipolar disorder, schizophrenia, attention-deficit/hyperactivity disorder, and autism spectrum disorder were associated with the symptoms of premenstrual disorders, using the PRS for height as a somatic comparator. The sample was recruited across Norway between June 1999 and December 2008, and analyses were performed from July 1 to October 14, 2022.

Main Outcomes and Measures

The symptoms of premenstrual disorders were assessed at recruitment at week 15 of pregnancy with self-reported severity of depression and irritability before menstruation. Logistic regression was applied to test for the association between the presence of premenstrual disorder symptoms and the PRSs for major psychiatric disorders.

Results

The mean (SD) age of 56 725 women included in the study was 29.0 (4.6) years. Premenstrual disorder symptoms were present in 12 316 of 56 725 participants (21.7%). The symptoms of premenstrual disorders were associated with the PRSs for major depression (β = 0.13; 95% CI, 0.11-0.15; P = 1.21 × 10−36), bipolar disorder (β = 0.07; 95% CI, 0.05-0.09; P = 1.74 × 10−11), attention deficit/hyperactivity disorder (β = 0.07; 95% CI, 0.04-0.09; P = 1.58 × 10−9), schizophrenia (β = 0.11; 95% CI, 0.09-0.13; P = 7.61 × 10−25), and autism spectrum disorder (β = 0.03; 95% CI, 0.01-0.05; P = .02) but not with the PRS for height. The findings were confirmed in a subsample of women without a history of psychiatric diagnosis.

Conclusions

The results of this genetic association study show that genetic liability for both affective spectrum disorder and major psychiatric disorders was associated with symptoms of premenstrual disorders, indicating that premenstrual disorders have overlapping genetic foundations with major psychiatric disorders.
Modeling the Rheological Behavior of a Novel Hot Isostatic Pressed Powder Metallurgy Superalloy
Authors: Yang Qiu-Mei , Lin Yong‐Cheng , Liu Guan , Chen Ming-Song , Qiu Yu-Liang
Published: May 2023

The rheological behavior and deformation mechanisms of a new powder metallurgy (P/M) superalloy at various deformation conditions are researched. The deformation conditions have significant influence on the rheological stress. Increasing the deformation temperature or decreasing the strain rate can decrease the rheological stress. The discontinuous hardening and softening phenomena are observed at the strain rate of 1 s−1, resulting from the complex phase transformation and dynamic recrystallization. Besides, the deformation activity energy (Q) declines with increasing the strain. The phenomenon is attributed to the spheroidization of γ′ phase and the decreased content/aspect ratio of γ′ phase. The deformation mechanisms of the researched superalloy are the accumulation of dislocation, stacking faults shearing, dislocations pinned by γ′ phase, and the formation of microtwins during hot deformation. The strain‐compensated Arrhenius and particle swarm optimization‐based backpropagation artificial neural network (PSO‐BP ANN) models are established to predict the rheological behavior. Compared to the strain‐compensated Arrhenius equation, the developed PSO‐BP ANN model presents the higher accuracy in predicting the rheological behavior of the researched alloy. Furthermore, for the developed PSO‐BP ANN model, the correlation coefficient is 0.9995, and the root mean square error is 1.224 MPa. So, the forecasted rheological stresses are consistent with the measured ones.
Diffuse large B‐cell lymphoma at risk of secondary CNS involvement: The inefficacy of intravenous high‐dose methotrexate CNS prophylaxis and the importance of baseline cerebrospinal fluid analysis
Authors: Bennett Rory , Ruskova Anna , Coomarasamy Christin , Theakston Edward , Berkahn Leanne , Jackson Sharon , Christophers Mina , Wong Stephen , Issa Samar
Published: May 2023

High‐dose intravenous methotrexate (HD‐MTX) CNS prophylaxis in high‐risk diffuse large B cell lymphoma (DLBCL) remains controversial. We describe real‐world CNS relapse incidence following baseline cerebrospinal fluid (CSF) analysis to exclude asymptomatic leptomeningeal involvement in newly diagnosed high‐risk DLBCL patients with versus without single‐route HD‐MTX CNS prophylaxis. Consecutively diagnosed high‐risk systemic DLBCL patients without leptomeningeal involvement by CSF analysis (noCNS) were identified retrospectively. Five‐year CNS relapse incidence and survival outcomes were examined, as stratified by receipt of HD‐MTX prophylaxis. Secondary analysis of survival outcomes in patients with synchronous leptomeningeal involvement (CNSinv) by CSF analysis at diagnosis were compared with the noCNS group. No significant difference in 5‐year CNS relapse incidence was observed following HD‐MTX prophylaxis versus no prophylaxis (total n = 445) despite similar CNS‐IPI risk; 6.2% versus 5.6%, adjusted HR 1.08 (95% CI 0.41–2.85), p = .88; nor in 5‐year progression free survival (PFS) or overall survival (OS) risk. Of CNSinv patients, 93.3% had ≥1 extranodal site. Increased CNS relapse/progression risk (5‐year risk; HR 10.7 [95% CI 5.35–21.37], p < .0001) and inferior PFS and OS were observed in CNSinv versus all noCNS patients. The CNSinv group had superior OS compared with noCNS patients who later experienced CNS relapse (HR 0.55, p = .052). HD‐MTX prophylaxis does not reduce CNS relapse risk in high‐risk systemic DLBCL without leptomeningeal involvement by CSF analysis at diagnosis. Asymptomatic patients with synchronous leptomeningeal involvement on baseline CSF examination are at increased risk of further CNS disease events and inferior survival compared to patients without CSF involvement.