bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparison between laparoscopic and robotic-assisted laparoscopic pyeloplasty in patients with ureteropelvic junction obstruction
Authors: Lukkanawong Niwat , Honda Masashi , Teraoka Shogo , Kimura Yusuke , Yumioka Tetsuya , Iwamoto Hideto , Morizane Shuichi , Hikita Katsuya , Takenaka Atsushi
Published: October 2020

Background

The aim of this study is to compare the results of laparoscopic pyeloplasty and robotic-assisted laparoscopic pyeloplasty in patients with ureteropelvic junction obstruction.
Methods

Between March 2008 and May 2019, the patients who underwent retroperitoneal laparoscopic or robotic-assisted laparoscopic pyeloplasty in our institution were retrospectively reviewed.
Results

Thirteen patients underwent laparoscopically, and 12 patients underwent robotic surgery. The significant difference was found in median operative time between laparoscopic group (296 minutes) and robotic group (199 minutes) (P = 0.001). The median time for drain removal in laparoscopic group was longer than robotic group (3 vs 2 days, respectively, P = 0.029).
Conclusions

Laparoscopic and robotic-assisted laparoscopic pyeloplasty is safe and excellent success rates in patients with ureteropelvic junction obstruction. However, our experience study suggested that robotic surgery improves a total operative time, decreases drain removal time and less intraoperative blood loss than laparoscopic approach.
Venous Doppler Ultrasound in Critically Ill Covid-19 Patients: Game Changer in Anticoagulation Therapy
Authors: Alfageme Marta , Plaza Jorge González , Collado María Luisa , Méndez Santiago , Patiño Juan A. Gómez , Abadal Jose M. , Costero Rocío González , Fontanilla Teresa , Suárez Agustín García
Published: October 2020

BackgroundCOVID-19 infection has been associated with a high rate of thrombotic events, such as deep vein thrombosis (DVT) and acute pulmonary embolism (APE).MethodsThe purpose of our retrospective study was to evaluate the prevalence of asymptomatic DVT in lower limbs in critically ill COVID-19 patients (n=23) with severe respiratory failure and high levels of D-dimer by bedside Doppler ultrasound (DU).ResultsDVT was diagnosed in 14 cases (60.87%), 5 in proximal venous territory and 9 in infrapopliteal veins. CTPA was performed in 6 patients and all of them showed acute pulmonary embolism (APE) at segmental or subsegmental branches of pulmonary arteries. These patients (APE or DVT confirmed) were treated with therapeutic doses of anticoagulant therapy.ConclusionIn critically COVID 19 ill ICU patients with severe respiratory failure y elevated D-dimer the incidence of asymptomatic DVT is high. We propose that DU allows detection of DVT in asymptomatic patients, adding a factor that may balance the decision to fully anticoagulated these patients.
Association between ambient air pollution and in vitro fertilization pregnancy outcomes in Taiyuan: A retrospective study in a heavy polluted city in northern China
Authors: Xu Suming , Sun Chunqing , Bi Xingyu , Feng Dan , Zhang Lei , Wang Chunfang , Wang Yaoqin , Wu Xueqing
Published: October 2020

BackgroundGlobally, air pollution has a significant impact on human health. However, the effects of air pollution on pregnancy outcomes in patients undergoing in vitro fertilization (IVF) have not been fully understood. In this study, we analyzed the effects of air pollution on IVF pregnancy outcomes in Taiyuan, which is a heavy polluted city in northern China.Methods516 patients who underwent first fresh IVF cycle were enrolled in the retrospective study from January 1, 2015 to May 31, 2020. We collected medical record data from the electronic medical record system and daily average air pollution data from air quality monitoring station. Logistic regression was used to analyze the relationship between six atmospheric pollutants (PM2.5, PM10, O3, NO2, SO2, CO) and air quality index (AQI) and IVF pregnancy outcomes (biochemical pregnancy and clinical pregnancy) in different exposure periods. ResultsThe results indicated that exposure to NO2 was negatively associated with the odds of biochemical pregnancy and clinical pregnancy, whereas exposure to O3 presented positive association. Furthermore, we also found that AQI was negatively associated with IVF pregnancy outcomes. ConclusionsOur findings suggested that exposure to ambient air pollution during any period may have an impact on IVF pregnancy outcomes, and poor air quality is more likely to reduce clinical pregnancy rates.
Health-Related Quality of Life in Postpartum Recovery of Women who Practice Hypopressive Physical Activity. Randomized Clinical Trial.
Authors: Sánchez-García Juan Carlos , Aguilar-Cordero María josé , Montiel-Troya Maria , Marín-Jiménez Ana Eugenia , Mellado-García Elena , Rodríguez-Blanque Raquel
Published: October 2020

BackgroundPracticing physical exercise is a way of maintaining a healthy lifestyle and it has been demonstrated that it benefits and improves quality of life after labour. Aim To determine whether a workout programme using the Low-Pressure Fitness methodology has an impact on the Health-Related Quality of Life after labour.Material and MethodWe carried out a 12-weeks randomized clinical trial. It started at week 16 after labour and ended at postpartum week 28. Women followed a moderate intensity workout programme, using the Low-Pressure Fitness methodology in the treatment group, and we had a control group of sedentary women to perform a comparison. We used the SF-36v2 questionnaire at the postpartum weeks 16 and 28 to assess the Health-Related Quality of Life in women.ResultsWe found statistically significant differences (p<0.05) in general health components, vitality, emotional role, and mental health in the sample group of women under the Low-Pressure Fitness, who obtained a higher score. We found statistically significant differences in all aspects between the postpartum weeks 16 and 28. The interaction between time and group affect in general health components, vitality, emotional role and the score of mental component. In all of them the score is higher at week 28 and in the Low-Pressure Fitness group.ConclusionsPhysical exercise, following the Low-Pressure Fitness method, improves Health-Related Quality of Life after labour. We found that, when both the treatment and control groups are categorized by body-mass index, the Low-Pressure Fitness method was not determinant to improve the postpartum Health-Related Quality of Life. The trial is registered at the US National Institutes of Health (ClinicalTrials.gov), under the title “Physical Activity in Pregnancy and Postpartum Period, Effects on Women”. Number NCT02761967.
Controllable Vesicular Size and Shape in Polymerization-Induced Self-assembly Aided by Aromatic Interactions
Authors: Xu Xiao-Fei , Zhu Ren-Man , Pan Cai-Yuan , You Ye-Zi , Zhang Wen-Jian , Hong Chun-yan
Published: October 2020

The size and shape of polymeric vesicles have great impact on their physicochemical and biological properties. Polymerization-induced self-assembly (PISA) is an efficient method to fabricate vesicles. In most PISA-cases, the formation of vesicles is driven by the solvophobic interactions which are lack of versatility on finely structural regulation. Herein, controlling vesicular size and shape is realized in PISA aided by aromatic interactions. Aromatic interactions between the membrane-forming blocks contribute to the augments of membrane tension which lead to the formation of smaller vesicles (as small as 70 nm), but overly enhanced aromatic interactions result in vesicle fusion rather than size decreasing. When the membrane tension is dominated by aromatic interactions and meanwhile high enough to overcome the energetic barriers of fusion, the aromatic interactions drive vesicle fusion in a directional manner to form tubular structures. The precise regulation of vesicular size and shape in PISA would pave the way to fabricate vesicles for a series of size/shape-dependent applications.
Comparison Robotic versus laparoscopic partial nephrectomy for Complex Renal Tumors (with a RENAL nephrometry score≥7): a meta-analysis
Authors: Jiang Yu-Li , Xiao Xin , Peng Fu-Sheng , Shi Tian-Li , Huang Xiao-Hui , Zhou Jin-Biao , Li Peng
Published: October 2020

BackgroundTo compare the perioperative outcomes of Robotic partial nephrectomy (RPN) versus laparoscopic partial nephrectomy (LPN). MethodsWe searched PubMed, EMBASE and the Cochrane Central Register for studies from 2000 to 2020 to evaluate the perioperative outcomes RPN and LPN in patients with a RENALnephrometry score≥7. We used RevMan 5.2 to pool the data. ResultsSeven studies were acquired in our study. No significant differences were found in the estimated blood loss (WMD: WMD: 34.49, 95% CI -75.16-144.14, p=0.54), hospital stay (WMD: -0.59 95% CI -1.24–0.06, p=0.07), operating time (WMD: -22.45, 95%CI: -35.06 to-9.85, ), postive surgical margin (OR: 0.85, 95% CI 0.65–1.11, p =0.23) and transfusion (OR: 0.72, 95% CI 0.48–1.08, p =0.11).between the two groups. RPN get better outcomes in postoperative renal function (WMD: 3.32, 95% CI 0.73–5.91, p=0.01), warm ischenia time (WMD: -6.96, 95% CI -7.30–-6.62, p <0.0001), conversion( OR: 0.34, 95%CI: 0.17 to 0.66, p=0.002) and intraoperative complication (OR: 0.52, 95% CI 0.28–0.97, p=0.04).ConclusionRPN could get better perioerative clinical outcomes than LPN for treatment of Complex Renal Tumors( with a RENALnephrometry score≥7).
The Influence of Single Nucleotide Polymorphisms of NOD2 or CD14 on Susceptibility to Tuberculosis: A Systematic Review
Authors: Cubillos-Angulo Juan M , Fernandes Catarina D , Araújo Davi N , Carmo Cristinna A , Arriaga María B , Andrade Bruno Bezerril
Published: October 2020

Background: Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with susceptibility or resistance to TB. Methods: A systematic review was performed on search platforms to examine the association between single nucleotide polymorphisms (SNP) and TB risk. Study quality was evaluated using the Newcastle-Ottawa Quality Scale (NOQS) Results: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased TB risk. In contrast, the genotype CC was found to be protective against the disease. Furthermore, in two studies, rs2569191 SNP of the CD14, G allele was described to be significantly associated with increased TB risk. Four studies reported data uncovering the relationship between NOD2 SNPs and TB risk, with two of them reporting significant associations of rs1861759 and rs7194886 and higher TB risk in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower TB risk in African Americans. Conclusions: The CD14 rs2569190 and rs2569191 polymorphisms influence TB risk depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of TB, especially in persons with Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in TB susceptibility and physiopathology; such effect may be affected by ethnicity.Systematic review registration: CRD42020186523
High-Frequency Neuronavigated Repetitive Transcranial Magnetic Stimulation for Depression in Major Neurocognitive Disorders: A Randomized Controlled Trial
Authors: Lu Hanna , Lin Cuichan , Chan Sandra Sau Man , Ma Suk Ling , Mok Vincent Chung Tong , Shi Lin , Wang Defeng , Mak Arthur Dun-Ping , Lam Linda Chiu Wa
Published: October 2020

Background: We evaluated the safety and efficacy of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in major neurocognitive disorder (NCD) patients with depression.Methods: In this single blind, sham-controlled clinical trial, 58 patients of major NCD with clinically significant depressive symptoms (Cornell Depression Scale for Dementia, CSDD ≥ 7) were enrolled and randomly (1:1) assigned for a three-week treatment of either active rTMS (10 Hz, 120% motor threshold, 1500 pulses/session) or sham (placebo-controlled) rTMS treatment. Structural magnetic resonance imaging (MRI) scans were employed to localize the stimulation targets and guide the TMS coil during the treatment. Severity of depressive symptoms, global cognitive function and the serum brain-derived neurotrophic factor (BDNF) level were evaluated at baseline, post-intervention and 6-weeks and 12-weeks follow-ups. Results: Twenty-seven participants were randomized to receive active rTMS and 28 to receive sham rTMS. Both groups showed improvement in depressive symptoms and cognitive function after 3 weeks rTMS treatment. Logistic regression analysis revealed that older age (p = 0.016), higher baseline cognitive function (p = 0.041) and randomization group (p = 0.025) were associated with the remission of depression (Nagelkerke R2 = 0.42). Conclusions: A 3-week course of 10 Hz rTMS appears to be a safe intervention for bringing quicker remission of depression for neurocognitive disorder patients. Trial registration: ClinicalTrials.gov, ChiCTR-IOR-16008191. Registered on March 30, 2016.
Predictors of Maternal and Neonatal Complications in Patients With Severe Valve Heart Disease During Pregnancy
Authors: Hammami Rania , BELHADJ Mohamed Ali , Mejdoub Yosra , Bahloul Amine , Charfeddine Selma , Abid Leila , Kammoun Samir , Dammak Abdallah , Chaabene Kais
Published: October 2020

Background: The severe valve disease especially stenosis is a contraindication to conception according to WHO. This situation is still encountered in countries with a high rheumatic fever prevalence. The objective of this study was to determine the predictors of maternal cardiac, obstetric and neonatal complications. Methods: This is an observationnal study of all pregnant women with severe valvulopathy, delivered between 2010 and 2017. Results: We included 60 pregnancies in 54 women. Cardiac complications occurred in 37 patients (61%). In multivariate analysis, the predictors for these complications were parity (OR = 2.41, p = 0.023), revelation of valvulopathy by pregnancy (OR = 6.34, p = 0.025), severe mitral stenosis (OR = 6.84, p = 0.035) and systolic pulmonary arterial pressure (OR = 1.08, p = 0.01). Obstetrical complications were noted in 19 women (31.8%). The predictive factors for these complications were primiparity (OR = 5.22, p = 0.032), multiple valve disease (OR = 5.26, p = 0.028), systolic pulmonary arterial pressure (OR = 1.04, p = 0.04) and treatment with vitamin K antagonist (OR = 8.71, p = 0.04). Neonatal complications were noted in 39% of new-borns. The predictive factors for these complications were the occurrence of obstetric complications (OR = 15.48, p = 0.001) and the revelation of valvulopathy by pregnancy (OR = 6.95, p = 0.017). Conclusions: The revelation of valve disease by pregnancy is predictor of not only cardiac complication but also neonatal complications, thus valve disease screening during pre-conceptional counselling is crucial.
Translating Evidence into Policy: Opinions and Insights of Health Researchers and Policymakers in Nepal
Authors: Tiwari Biplav Babu , Ban Anusha , Gurung Sony , Karki Khem Bahadur
Published: October 2020

Background: The Evidence-Based Policymaking (EBP) process in Nepal is rife with poor practices where often policymakers are portrayed as perpetrators for such practices. However, we need to think of the EBP as a two-sided coin where both research pull and research push play equally significant roles. Methods: Therefore, through 12 in-depth interviews, this study aimed to assess the perception of Nepalese health policymakers and researchers on EBP and identify appropriate mechanisms to integrate evidence into policies. Following the constructivist philosophical paradigm, qualitative research design was used in the study with the grounded theory approach. Purposive sampling was performed and the total number of interviews was finalized following saturation theory. All interviews were audio-recorded, transcribed, translated to English, coded line by line, and then developed into themes. Thematic analysis technique was used to manually analyze the data. Results: Study participants highlighted that evidence is being utilized during policy formulation but not in the amount it should be, with a preference for anecdotal evidence further reducing the chance. Apart from these barriers, poor credibility of information obtained, poorly targeted dissemination, inadequate policy-based researches, and policymakers and researchers operating within the spheres of their own with a feeble link to channel the flow of information between them were identified by participants. On the other hand, the publication of one-pager research brief, conduction of nationally representative surveys especially quantitative studies, the practice of cost-effectiveness study, and policymaker’s involvement during the research were some facilitators identified. Conclusions: Moreover, the study accentuates that better communication strategies such as the establishment of formal forums with policymakers and researchers, better-targeted dissemination, and identification of priority areas have wide potential to promote a unified front of health policymakers and researchers for EBP.
Hepatectomy Provides Good Long-Term Outcomes for Hepatocellular Carcinoma Patients With Portal Hypertension: A Propensity Score Matching Analysis
Authors: Wu Xiwen , Chen Wei , Chen Bin , Xie Wenxuan , Wang Shutong , Peng Baogang , Shen Shunli
Published: October 2020

Background: The role of hepatectomy in hepatocellular carcinoma (HCC) with portal hypertension (PH) remains controversial. This study aimed to evaluate the effect of hepatectomy on overall survival (OS) of HCC patients with PH.Methods: A total of 1651 HCC initially treated with hepatectomy were retrospectively reviewed and divided into PH group (n=157) or non-PH group (n=1494). Propensity score matching (PSM) was conducted to match the baseline characteristics of the PH group and non-PH group. Results: The PH group presented a similar OS (p=0.29) and recurrence free survival (RFS) (p=0.83) compared with non-PH group after initial hepatectomy before PSM. After PSM processing, the baseline characteristics were highly comparable for both groups (133 patients in each group). The PH group also presented a similar OS (p=0.81) and RFS (p=0.65) compared with non-PH group after initial hepatectomy. After PSM, multivariate analysis identified tumor size (>5 cm) (p=0.02), macro-venous invasion (p < 0.001), AST (>37 U/L) (p =0.008) as independent risk factors for OS.Conclusions: Hepatectomy provides good long-term outcomes for HCC patients with PH. PH should not be regarded as a contraindication for hepatectomy in HCC patients.
Hospital Case-Volume and Mortality After Ovarian Cancer Surgery: A Population-Based Retrospective Cohort Study
Authors: Kim Bo Rim , Kim Heewon , Joo Se-gyeong , Jang Eun Jin , Jo Junwoo , Lee Hannah , Ryu Ho Geol
Published: October 2020

Background: The goal of ovarian cancer surgery has recently shifted from optimal cytoreduction to more complete resection. This study attempted to reassess and update the association between surgical case-volume and both in-hospital and long-term mortality after ovarian cancer surgery using recent data.Methods: Data from all adult patients who underwent ovarian cancer surgery in Korea between 2004 and 2017 were obtained from the database of Korean National Health Insurance Service. Hospitals were categorized by average annual number of surgeries considering overall distribution of case-volume. Postoperative in-hospital and 1, 3, 5-year mortality were analyzed using logistic regression. Results: During the study period, 23,487 ovarian cancer surgeries were performed in 354 hospitals. High-, medium-, and low-volume centers were defined as >100 cases/year, 30-100 cases/year, and <30 cases/year, respectively. In-hospital mortality was significantly higher in medium-volume (1.63%; adjusted odds ratio, 2.28; confidence interval, 1.64-3.17; P <0.001) and low-volume (1.62%; adjusted odds ratio; 2.12; confidence interval, 1.55-2.90; P <0.001) centers compared to high-volume centers (1.13%). In addition, 1-year mortality after ovarian cancer surgery was 6.26%, 7.07%, and 8.06% for high-volume, medium-volume, and low-volume centers, respectively, and the differences among the groups were significant. However, case-volume effect was not apparent in 3- and 5-year mortality after ovarian cancer surgery.Conclusion: Case-volume effect was observed for in-hospital and 1-year mortality after ovarian cancer surgery while no clear association was found between the case-volume and 3- or 5-year mortality.
Morphological, Physiological, and Molecular Responses of Sweetly Fragrant Luculia Gratissima During the Floral Transition Stage Induced by Short-day Photoperiod
Authors: Liu Xiongfang , Wan Youming , An Jing , Zhang Xiujiao , Cao Yurong , Li Zhenghong , Liu Xiuxian , Ma Hong
Published: October 2020

Background: Photoperiod-regulated floral transition is vital to the flowering plant. Luculia gratissima ‘Xiangfei’ is a flowering ornamental plant with high development potential and is a short-day woody perennial. However, the genetic regulation of short-day-induced floral transition in L. gratissima is unclear. To systematically research the responses of L. gratissima during this process, dynamic changes in morphology, physiology, and transcript levels were observed and identified in different developmental stages of long-day and short-day-treated shoot apexes. Results: The results showed that floral transition in L. gratissima occurred 10 d after short-day induction, but flower bud differentiation did not occur under long-day conditions. A total of 1,226 differentially expressed genes were identified, of which 146 genes were associated with flowering pathways of sugar, phytohormones, photoperiod, ambient temperature, and aging signals, as well as floral integrator and meristem identity genes. The trehalose-6-phosphate signal positively modulated floral transition by interacting with SPL4 in the aging pathway. Endogenous gibberellin, abscisic acid, cytokinin, and jasmonic acid promoted floral transition, whereas strigolactone inhibited it. In the photoperiod pathway, FD, COL12, and NF-Ys positively controlled floral transition, whereas PRR7, FKF1, and LUX negatively regulated it. SPL4 and pEARLI1 positively affected floral transition. SOC1 and AGL24 integrated multiple flowering signals to modulate the expression of FUL/AGL8, AP1, LFY, SEPs, SVP, and TFL1, thereby regulating floral transition. Finally, we propose a regulatory network model for short-day-induced floral transition in L. gratissima. Conclusions: Short-day photoperiod activated systemic responses of morphology, physiology, and transcript levels in L. gratissima and induced the generation of floral transition signals in the photoperiod pathway. Furthermore, multiple flowering signal pathways including phytohormone-, sugar-, temperature-, age-related genes synergistically control this process. This study improves our understanding of flowering time regulation in L. gratissima and provides knowledge for its production and commercialization.
Ionic Homeostasis, Acid-base Balance and the Risk of Citrate Accumulation in Patients After Cardiovascular Surgery Treated With Continuous Veno-venous Haemofiltration With Post-dilution Regional Citrate Anticoagulation
Authors: Kośka Agnieszka , Kowalik Maciej Michał , Lango-Maziarz Anna , Karolak Wojtek , Jagielak Dariusz , Lango Romuald
Published: October 2020

Background: Patients with known or new-onset acute renal failure after cardiovascular surgery, requiring renal replacement therapy, can benefit from adequate non-heparin circuit anticoagulation. The idea behind not using heparin relates to the post-operative risk of bleeding. Simplified regional citrate anticoagulation (RCA) protocol proposes the use of citric acid dextrose formula A (ACD-A) during post-dilutional continuous veno-venous hemofiltration (CVVH) with standard bicarbonate buffered calcium containing replacement solution. Citrate accumulation diagnosed upon total to ionized calcium ratio (tCa/iCa) and low ionized calcium (iCa) are considered as the biggest risks related to regional citrate accumulation.Methods: This prospective observational study evaluated electrolyte and acid-base homeostasis in cardiovascular surgery patients with known chronic or new-onset acute renal failure treated with post-dilution continuous veno-venous haemofiltration (CVVH) with a simplified RCA protocol with ACD-A. In total, 50 consecutive cardiovascular surgery patients treated with CVVH with RCA were evaluated. Base excess; pH; bicarbonate, lactate, Na+, Cl-, Mg++, and inorganic phosphate concentrations; the total to ionized calcium ratio (tCa/iCa); and high anion gap metabolic acidosis were assessed during haemofiltration treatment in survivors and non-survivors.Results: Thirty-three (66%) patients died. In total, 235 haemofiltration sessions with a median circuit survival time of 57 hours (1-117) were evaluated. The therapies were very well balanced with regard to sodium and chloride homeostasis. The lactate concentration and anion gap decreased during CVVH sessions longer than 72 hours, but no inter-group difference was observed. The tCa/iCa ratio exceeded 2.5 in 11 of 246 (4.5%) readings and was significantly higher in non-survivors (p=0.037). No correlation was observed between the lactate concentration before haemofiltration and the tCa/iCa ratio during haemofiltration. Magnesium and phosphate concentrations decreased during CVVH, and additional supplementation with magnesium was necessary. The magnesium concentration was lower in the non-survivors.Conclusions: The CVVH RCA protocol provides stable sodium and chloride concentrations and a tendency towards higher pH values and bicarbonate concentrations. Supplementation with magnesium and phosphate ions is needed. The incidence of citrate accumulation exceeded 4% and was significantly higher in non-survivors.Trial registration: retrospectively registered: Clinicaltrials.gov, NCT03836742.
Naringenin, a Flavonoid, Modulates Gut Microbiome and Ameliorates Hormone Levels to Improve Polycystic Ovary Syndrome in Letrozole-induced Rats 
Authors: Wu Yan-Xiang , Yang Xiu-Yan , Hu Yuan-yuan , An Tian , Lv Bo-Han , Lian Juan , Wang Ting-Ye , Bao Xue-Li , Zhu Jia-Jian , Gao Lin , Jiang Guangjian
Published: October 2020

Background: Polycystic ovary syndrome (PCOS) is a common female endocrinopathy, which severely affect the menstruation and fertility of patients. Naringenin, a natural flavanone, has emerged as a potential therapeutic agent for the management a variety of diseases. However, the underlying mechanism of naringenin in anti‑PCOS is unclear. This study was focused on investigating the effects of naringenin on body weight, ovarian tissue, serum hormone level, glucose metabolism level and gut microbiome in letrozole-induced PCOS model rats.Methods: First, we administered letrozole gavage to 10-week-old SD female rats for 4 weeks to induce PCOS rats model, the estrus cycle was observed through the vaginal smear of rats to determine the establishment successful of a PCOS rat model. Then, the successfully modeled PCOS rats were treated with naringenin for 2 months. Finally, observed the changes of rat body weight, ovarian tissue, serum hormone level, glucose metabolism level and gut microbiome after naringenin treatment. Results: The naringenin treatment ameliorate the hormone levels, such testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), improve insulin resistance and the ovarian tissue pathological changes, reduced body weight in the PCOS model rat. Meanwhile, through the detection of rDNA in the faeces of the PCOS model rat, we found some beneficial microbes such [Ruminococcus], Faecalibacterium, Butyricimonas, Lachnospira, Parabacteroides, Butyricicoccus and Roseburia were enrichment in naringenin group when compared with the PCOS rats. Conclusions: In summary, our results indicated that naringenin could play an anti-PCOS role, and its mechanism may be closely related to regulating the beneficial microbes of gut microbiome. Our research could provide a new perspective for the treatment of PCOS and its related disease.
Examining the Prognostic Utility of Frailty for Post-arrest Outcomes Following the Provision of Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis Protocol
Authors: Mowbray Fabrice I , Foroutan Farid , Fernando Shannon , McIsaac Daniel , Douma Matthew , Wit Kerstin de , Muscedere John , Nolan Jerry , Griffith Lauren E , Worster Andrew , Couban Rachel , Costa Andrew , Strum Ryan , Correia Rebecca , Manlongat Donna
Published: October 2020

BackgroundAdvanced knowledge of patient prognosis following a cardiac arrest is necessary to determine if resuscitation efforts are futile and ensure value-congruent care. Prior reviews have identified the prognostic factors associated with survival and recovery following cardiac arrest. However, few studies to date have examined the prognostic value of frailty in predicting post-arrest outcomes. The objective of this systematic review is to synthesize the available evidence reporting the association between frailty and patient outcomes following the provision of CPR in-hospital or out-of-hospital MethodsWe searched the following electronic databases from inception until August 2020: Medline Epub Ahead of Print, In-Process and Other Non-Index citations, Pubmed exclusive of Medline citations, EMBASE, CINAHL and Web of Science. We plan to include observational studies that examine the association between frailty and any of the following outcomes: survival to hospital discharge, survival at one, three and twelve months post-arrest, return of spontaneous circulation, functional status at hospital discharge and one-month post-discharge, health-related quality of life at 90 days and one-year post-arrest, and discharge to continuing or long-term care. We plan to conduct a random-effects meta-analysis that pools the effect estimates from all eligible studies to obtain a summary estimate and confidence interval. DiscussionThe findings of this review can be used to determine if the evidence supports the consideration of frailty when discussing advanced directives and care planning with patients, families and caregivers. The findings of this review can also be used to inform future prognostic and clinical prediction models aiming to predict post-resuscitation outcomes. Systematic Review RegistrationThis review has been submitted to the PROSPERO registry (submission ID: 212922)
DTI for Parkinson's Disease: A Protocol for Systematic Review and Meta-Analysis
Authors: Yin Xiaoqin , Liu Meijun , Liao Yang , Jin Shuoguo , Li Qizheng , Zhu Chan , Hou Xiaolin , Yang Dongdong , Chu Xing
Published: October 2020

Background: There is no robust biological marker for the diagnosis of Parkinson's disease, and most of them are diagnosed until motor symptoms develop, which may affect the early intervention and prognosis Objective: To evaluate the diagnostic value of different parameter values of DTI in PD.Methods and analysis: We will systematically search the cochrane, pubmed, and embase databases, but we only consider observational studies and English studies. The main outcomes are DTI parameters, including FA, MDC, and ADC. We will evaluate the quality of the included studies through the NOS scale, and the data synthesis will be analyzed by revman5.3.Discussion: This systematic review will integrate all relevant DTI observation results on PD imaging, and evaluate whether DTI can be used as a biological marker for the diagnosis of PD. The review results will provide a useful reference for the diagnosis of PDSystematic review registration: The protocol has been registered at the International Platform of Registered Systematic Review and Meta-analysis Protocols(INPLASY202070098).
Liver Transplantation, IBD Clinical Course, Is There a Link? A Systematic Review and Meta-Analysis Protocol
Authors: Sivandzadeh GholamReza , Mehrabi Manoosh , Safarpour Ali Reza , Ashrafizadeh Hadis , Keshtkar Abbas Ali
Published: October 2020

BackgroundPrimary sclerosing cholangitis (PSC) is an uncommon chronic and progressive cholestatic liver disease. There is a robust association between PSC and Inflammatory Bowel Disease (IBD), usually Ulcerative Colitis (UC). According to the review of literature, the incidence of de novo IBD after solid organ transplantation (SOT) is found to be higher than general population. Considering lacking of any systematic review and pursuing debate on the clinical course and risk factors of IBD activity after Liver Transplantation (LT), the present study will be performed with a focus investigation on the correlation of IBD clinical course with liver transplantation. MethodsIn this systematic review, the electronic databases including PubMed/MEDLINE, Scopus, WoS (Clarivate Analytics), Embase (Embase.com), and ProQuest will be searched. Our search strategy (i.e. The eligibility criteria) covers prospective and retrospective observational studies that evaluated the clinical course of ulcerative colitis or/and Crohn’s disease after liver transplantation with no language limitation published between 1970.01.01 and 2020.03.30. The selection phase, data extraction and quality assessment will be independently implemented by two authors. In case of any disagreement between the authors, the issue will be resolved by consensus; if not resolved, the opinion of a third expert will be asked. We will use one of the following two models: Random Effect Model or Fixed Effect Model according to the severity of methodological heterogeneity and forest plot will present the combination of data obtained from all finally included studies, to show the separated and combined frequency and their corresponding 95% CIs. Statistical heterogeneity will be evaluated by the Q-statistic test and I2 statistics. Funnel plot for assessing the potential reporting bias, Begg's and Egger's tests for meaningful results of the publication bias, and the Fill & Trim method for corrected publication bias will be used. DiscussionThis systematic review and meta-analysis study will clarify the correlation of IBD clinical course with liver transplantation. Because of the importance of inflammatory bowel disease, if the future study reveals consistent results, it will be clinically beneficial for physicians and other health care professionals to better manage inflammatory bowel disease after liver transplantation.Systematic review registrationPROSPERO, CRD42020179412.
Three-dimensional Printing in Spine Surgery: Protocol of a Systematic Review and Meta-analysis
Authors: Xie Guanli , Wang Tao , Jiang Bo , Yang Chunyan , Li Deguang , Su Yan , Xie Xiuping , Sun Haoming , Li Jian , Li Lvyu , Liao Jianglong
Published: October 2020

BackgroundThe complexity and diversity of spine pathology lead to the complexity and diversity of spinal surgery. The emergence and application of three-dimensional printing (3DP) technology has brought good news to surgeons and patients. However, the use of 3DP in spinal surgery remains controversial. Therefore, this study was designed to investigate whether 3D printing technology is beneficial for spinal surgery.MethodsThree English online databases including EMBASE (via embase.com), Medline (via PubMed), and Cochrane Central Register of Controlled Trials (CENTRAL) will be searched from inception until August 31, 2020. Document records retrieved according to the pre-defined search strategy will be managed by EndNote X7. The MINORST (methodological index for non-randomized studies) item recommended for non-randomized controlled interventional studies in surgery will be used to assess the quality of non-randomized controlled studies. The “Risk of bias” (ROB) table will be used to assess the quality of randomized controlled studies. The data extraction will be completed by two authors independently, one of whom extracts and the other checks. If there is any missing data, original author will be contacted to obtain the data required. Any inconsistencies were agreed upon by discussion with a third investigator. If the collected data can be synthesized, Review Manager (RevMan5.3) will be used to estimate the overall effect of 3DP for Spinal surgery. Otherwise, only the qualitative analysis will be carried out. According to the results of clinical heterogeneity test, random effects model or fixed effects model will be used for data synthesis. The sources of clinical heterogeneity will be explored by meta-regression and subgroup analysis. If more than 10 studies are included, funnel plots will be used to assess the publication bias. This review will be carried out in strict accordance with Cochrane Handbook for Systematic Reviews of Interventions.ConclusionThis study will can provide surgeons and patients with evidence-based evidence for the use of 3D printing technology in spinal surgery.Systematic review registrationPROSPERO/ID = CRD42020204053.
Summer STEM Course Gone Viral: A Virtual Curriculum Development
Authors: MacKinnon Grant , Langford Kyle , Harper Holly , Brown Kelsei , Divakar Sushmitha , Limb Mollie , Alexander Louise , Brown Charlotte
Published: October 2020

Due to the COVID-19 pandemic, a high school academic summer course concentrated in medicine was converted from a three-week on-campus experience to a two-week virtual course. While attending a residential summer course may be a barrier for some students, a virtual program may provide an equally rigorous and rewarding experience.
La reducción de riesgos y daños vs. el régimen internacional de control de drogas (1990-2017)
Authors: Peña Barona Enrique Andres
Published: October 2020

A pesar de la evidente efectividad de ciertos programas de Reducción de Riesgos y Daños de Drogas (RRDD), el Régimen Internacional de Control de Drogas (RICD) históricamente ha desincentivado su implementación, los defensores de la cara más rígida del RICD se han referido a la RRDD como el caballo de Troya de las facciones que defienden la legalización. No obstante, una gran cantidad de Estados han hecho uso del margen de flexibilidad interpretativo de las Convenciones internacionales de drogas para implementar en sus políticas nacionales estrategias de RRDD, algunas promovidas inclusive por órganos propio de Naciones Unidas como la OMS, UNODC y UNAIDS. A partir de una revisión de literatura, este documento evalúa las principales tensiones que han ocurrido dentro del RICD a causa de la perspectiva de RRDD entre 1990 y 2017.
Loop-mediated isothermal amplification holds great potential for massive COVID-19 diagnostics
Authors: Fomicheva K.A , Osipyants A.I. , Shkurnikov M.Y. , Pokryschenko A.A. , Tonevitsky E.A. , Vechorko V.I.
Published: October 2020

Real-time RT-PCR currently remains most popular for early COVID-19 diagnostics. However Loop-mediated isothermal amplification (LAMP) method outperform real-time RT-PCR in rapidity and simplicity because it doesn't require expensive laboratory equipment and trained personnel. LAMP-based diagnostic kits for COVID-19 testing are already exist, but LAMP-based tests are not yet widely adopted. The method has great potential for mass application. Here we discuss technical and methodological aspects of its widespread implementation.

COVID-19, SARS-CoV-2, LAMP, loop-mediated isothermal amplification, diagnostics, coronavirus.

This work was supported by a grant from the President of the Russian Federation for state support of young Russian scientists - candidates of sciences (MK-1906.2019.4).
No dia do julgamento... de costas para a história!
Authors: Ferraz Deise Luiza Da Silva
Published: October 2020

O Julgamento foi título que atribuí à imagem que sempre me observa quando transito entre a Faculdade de Filosofia e Ciências Humanas e a Faculdade de Ciências Econômicas da Universidade Federal de Minas Gerais. Esta arte do movimento Graffiti está repleta de informações e a mensagem que salta aos olhos é a inexistência de neutralidade no julgamento daquilo que se faz nas universidades. Ensino, Pesquisa e Extensão estão conectados a um projeto de universidade e este projeto atende a determinados interesses, cujos destinatários estão muito bem retratados na imagem. Por outro lado, nós, a comunidade acadêmica, longe de sermos neutros, também compomos contribuindo, às vezes mais às vezes menos, com tal projeto. Em verdade, na imediaticidade da vida, os destinatários nos julgam. Julgam à quem vai a verba de pesquisa, julgam à quem vai a bolsa de estudo, mas ainda haveremos de ser julgados pela história, por nos abstermos que questionar, como já fez Maurício Tragtenberg, Para quê e para quem serve seu conhecimento? A imagem da capa estampa, por meio da arte, a urgência de darmos resposta a estas indagações se desejarmos que o projeto de universidade abandone seus destinatários de sempre e se coloque a serviço do avanço da humanização e não da acumulação de capital. Ademais, se considerarmos a perspectiva histórica da luta de classes, pode haver dificuldades futuras para compreender-se o porquê nos contentarmos com um “universidade includente” quando podemos produzir com cada um e cada uma a universidade para todos e todas. Como explicar que a universidade ao assumir-se  instrumento de inclusão, não está sendo tolerante com as condições que reproduzem a exclusão? Ao que parece, aos olhos do juiz em retratado, tal explicação não deveria ser foco de nossa atenção.
Administração Política e os Estudos Organizacionais
Authors: Cristaldo Rômulo Carvalho
Published: October 2020

Nesse artigo teórico se pretende compreender o campo de conhecimento da administração política a luz dos, e em relação aos, estudos organizacionais. Para tanto, recuperamos os fundamentos epistemológicos da administração política para analisa-los por meio de quatro diferentes modelos interpretativos: os paradigmas sociológicos de Burrell e Morgan; as metanarrativas nos estudos organizacionais segundo Michael Reed; o círculo de matrizes epistêmicas de Ana Paula P. de Paula; e a matriz das abordagens críticas em gestão de Thomas Klikauer. O método empregado foi a revisão sistemática de literatura. Ao final, chagamos ao entendimento de que, diferentemente do que defendem os propositores do campo, a Administração Política se aproxima do funcionalismo, se valendo de uma narrativa da justiça, por meio de uma abordagem sociológica híbrida e proporcionando não mais do que uma abordagem crítica reformista.
Curved water flow characteristics and its influence on navigation
Authors: Li Haopeng , Dong Hongcang , Ji Pengxiang
Published: October 2020

The ship movement is mainly affected by the circulation current in curve channel. In this paper, the curve circulation is taken as the research object, 3D model is established and scientific numerical simulation is carried out. In order to study and analyze the difference, three curve models with different bending degrees are established in this simulation. Finally, according to the simulation results, the measures for safe navigation are proposed.
Liquefaction identification based on instantaneous H/V spectrum ratio
Authors: Yinfeng Dong , Dong Li , Jianli Rao , Xu Huang
Published: October 2020

The strong vibration record contains a lot of information on the site during the earthquake, and the dynamic characteristics of the soil layer in the site can be expressed through this information. Currently, the H/V spectral ratio recorded by acceleration is often used to study the seismic effect of the site. Inspired by this, the thesis puts forward the idea of using the instantaneous H/V spectral ratio and its corresponding instantaneous frequency to judge the site liquefaction. The time-varying VARMA model is used to represent the horizontal ground motion component as the output of a time-varying system with vertical ground motion component as input. According to the time-varying VARMA parameters, the instantaneous spectral ratio, instantaneous frequency of the system and instantaneous damping ratio are used to judge the site liquefaction.
Dynamic load of the carrying structure of an articulated wagon with new draft gear concepts
Authors: Fomin Oleksij , Lovska Alyona , Píštěk Václav , Kučera Pavel
Published: October 2020

The article deals with a new draft gear concept proposed by the authors to reduce the dynamic load of wagons in operational modes. The peculiarity of the concept is transformation of the kinetic impact energy into the work of viscous resistance forces when the viscous fluid passes through the throttle openings of the piston. The concept can be introduced for the wagons, in which centre sills of the frames are of closed sections. The mathematic modelling was conducted for the dynamic load of articulated wagons with consideration of the draft gear concept. It was established that the use of the draft gear concept can lower the dynamic load of wagons by about 10 %. The research will encourage engineers to design modern structures of rolling stock units and increase their operational efficiency.
Numerical simulation research on s-shaped elbows polished by abrasive flow based on large eddy simulation
Authors: Zhao Weihong , Qu Jiyong , Peng Qifei , Hui Ximing , Li Junye , Liang Dong
Published: October 2020

To predict and improve the surface quality of complex curved surface structure precision machined by solid-liquid two-phase abrasive flow, this paper takes the S-shaped elbow as the research object, carries out the numerical simulation of abrasive flow polishing process of S-shaped elbow based on large eddy simulation method, analyzes the velocity distribution of abrasive flow, turbulent energy, wall shear force nephogram and trace diagram of abrasive flow in the S-shaped elbow under different inlet speed and abrasive concentration conditions. It is found that the values of velocity, turbulent energy and wall shear force on the inner side of the elbow and the outlet pipe are relatively large, indicating that the polishing quality at these positions is better. Increasing the inlet velocity can improve the effectiveness of abrasive flow polishing, and properly increasing the abrasive concentration can improve the surface uniformity of polished wall. It can provide a theoretical basis for promoting the continuous improvement of abrasive flow precision machining technology.
Effect of molding technology and porosity on explosive combustion
Authors: Li Hong-Bin , Yang Jian , Jin Peng-Gang
Published: October 2020

In order to understand the reaction growth characteristics and its influencing factors of typical explosives after non-impact ignition, a device and method for studying the reaction growth characteristics of explosives after non-impact ignition were established. The effects of explosive composition, forming process and porosity on the reaction growth after ignition were studied by this method. The research on ZY-5 explosive shows that the change of explosive composition can significantly affect the reaction state of explosive after ignition. The microstructure of combustion products is studied by scanning electron microscopy. It is considered that the bonding and combustion products of hydroxyl-butadiene system used in pouring explosive construct a space network with flame retardant function, which plays a very good role in flame retardant. Inhibition.
Study on hydraulic sand suction performance of suction cutter
Authors: Kong Yuange , Wu Miao , Zhuang Lan , Zhou Xiaojun
Published: October 2020

The sand absorption performance of the suction cutter affects the sand removal effect of the oil-water separator to a great extent. The bottom flow field model of the separator tank with the suction cutter is established by means of numerical simulation, which includes the determination of the applicable solid-liquid two-phase flow model and the establishment of the basic fluid dynamics equation in line with the reality. After Gambit was used to divide the mesh, Fluent software was used to analyze the influence of sand suction cutter placement Angle, sand suction velocity, sand suction distance and other factors on sand suction performance. It is found that with the adjustment of many factors, the hydraulic sand absorption performance of the suction cutter changes obviously.