bluuebunny/crossref_metadata_2025 huggingface dataset:
TENDÊNCIAS DE DESIGN PARA SITES DE MARCAS DO MERCADO DA MODA
Authors: Scutare Talita de Oliveira , Del Vechio Gustavo Henrique
Published: December 2019

Projetar layouts de sites da web não é apenas uma questão de pensar em beleza ou estética. Mais do que isso, é preciso planejar cuidadosamente cada elemento visual, tendo em vista sua função ou sua contribuição para garantir uma ótima experiência de navegação, ao mesmo tempo em que apresenta, com clareza, o conteúdo de cada página. Posto dessa forma, este estudo procura avaliar como o design de página, por meio de geometrias, imagens, cores e tipos de texto combinam-se a fim de garantir uma boa percepção visual, enquanto destaca a marca e o conteúdo projetado para cada página. Neste caso, deseja-se analisar, mais especificamente, as marcas do segmento da moda (de luxo), a fim de compreender melhor certas tendências quanto à projeção de seus layouts. Entender, afinal, como as marcas mais famosas neste segmento projetam seus layouts pode ser muito útil para outras marcas se inspirarem e caminharem na mesma direção. A constatação deste estudo é que um design minimalista, que está menos preocupado em detalhes ou efeitos para o layout e mais focalizado na exibição imagética das peças e itens de moda, é muito mais vantajoso para destacar os modelos e coleções, que se renovam frequentemente e precisam chamar a atenção daqueles que se interessam em acompanhar ou estar sempre atualizados com a moda.
COMO A IMPLEMENTAÇÃO DAS BOAS PRÁTICAS DE FABRICAÇÃO (BPF) AUXILIAM A COMPETITIVIDADE E A QUALIDADE EM UMA INDÚSTRIA
Authors: Buzinaro David Vinicios Chiarello , Gasparotto Angelita Moutin Segoria
Published: December 2019

As empresas estão buscando a implantação das Boas Práticas de Fabricação (BPF) devido à competitividade, melhoria contínua, exigência do mercado consumidor e, principalmente, a higiene alimentar dos seus produtos. Os sistemas de gestão, controle de qualidade e treinamentos dos colaboradores são, atualmente, um diferencial na indústria alimentícia. A qualidade é a principal característica das indústrias. Esse fato se dá devido à mudança de postura dos consumidores mundialmente, os quais procuram produtos que tragam e transmitam segurança, sejam atraentes e, além disso, sejam fabricados de forma sustentável. Nesse contexto, existe uma forma para que se possa obter e garantir a qualidade e a garantia nas indústrias: a implementação do programa de Boas Práticas de Fabricação - BPF’s.
IMPORTÂNCIA DAS FEIRAS LIVRES E SEUS IMPACTOS NA AGRICULTURA FAMILIAR
Authors: Carvalho Francislene de Fátima , Grossi Selma de Fátima
Published: December 2019

A agricultura familiar tem como objetivo em seu sistema de produção a diversificação de cultura que permite aos produtores a obtenção de alimentos e renda os doze meses do ano. Esse segmento de produção é significativo devido a sua função ambiental, econômica e social tornando-se imprescindível para produtores familiares, pois é por meio desta que ocorre a venda e agregação do valor no produto. Como valor agregado refere-se aos produtos derivados da sua produção original, como doces, verduras lavadas e embaladas, produtos artesanais e utensílios que contribuíram com a renda da família.  Os produtores rurais deparam com inúmeras dificuldades nesse elo. Sendo assim, a escolha do canal de distribuição para a venda dos produtos pelos produtores familiares, passa a ser, um fator essencial para a estratégia de comercialização. Nesse contexto, uma das alternativas de comercialização que os produtores familiares estão abraçando são as feiras-livres.
IMPORTÂNCIA DA GESTÃO DE PESSOAS NO AGRONEGÓCIO
Authors: Silva Lavinia Gabriele da , Pandolfi José Guilherme , Pandolfi Marcos Alberto Claudio
Published: December 2019

Este trabalho teve como objetivo apresentar a importância da gestão de pessoas no setor do agronegócio onde o seu papel é imprescindível dentro das organizações, devido ao conjunto de práticas que objetivam adequação dos indivíduos ao ambiente de trabalho para a realização das atividades. Para isso esse estudo teve como base a revisão bibliográfica com o objetivo de identificar quais são as práticas de gestão de pessoas utilizadas pelos agricultores, durante o recrutamento e seleção, treinamento e desenvolvimento, motivação e remuneração. Neste sentido, a pesquisa aponta que a solução depende dos procedimentos do gestor durante o processo de decisão, cabendo a ele enxergar um novo modelo de gestão, se adequando e estabelecendo critérios que possam aproveitar o potencial de cada pessoa, a fim de se obter melhores resultados para a empresa. Com as novas tecnologias chegando ao mercado, com o intuito de melhorar a produção o produtor ou proprietário tem que estar preparado com funcionários qualificados para atender essa demanda.
CONCEITO DE INDÚSTRIA 4.0 E OS PRINCIPAIS DESAFIOS DE SUA IMPLANTAÇÃO NO BRASIL
Authors: Vello Ana Cristina Pinheiro , Volante Carlos Rodrigo
Published: December 2019

A indústria mundial vem sofrendo grandes mudanças desde o desenvolvimento dos parques fabris e a tecnologia está cada vez mais presente nela. Neste contexto surgiu a indústria 4.0 ou quarta revolução industrial que tem como alguns de seus pilares os sistemas ciber-físicos (CPS) e a Internet das Coisas (IoT). O objetivo deste artigo é apresentar os conceitos da “Indústria 4.0” e verificar quais são os desafios principais para implantá-la, em especial no Brasil. A metodologia adotada neste trabalho foi a pesquisa bibliográfica que possibilitou abordar a definição de vários autores acerca do tema além da elaboração de um quadro que reuniu trabalhos de autores brasileiros onde foram evidenciados alguns dos desafios das empresas brasileiras ao implantar ou tentar implantar algumas tecnologias trazidas pelo novo modelo de indústria. Foi possível considerar que, no Brasil, a carência de mão de obra especializada, o apoio do governo com políticas estratégicas e a falta infraestrutura tecnológica são os mais apontados.
CONTABILIDADE DE CUSTOS NO SETOR DE HOTELEIRO DE GUARAPARI-ES: ANÁLISE DA PERCEPÇÃO DE RELEVÂNCIA E CONHECIMENTO PELA MATRIZ DE SLACK
Authors: Dumer Miguel Carlos Ramos , Mariani Elisângela Parteli , Mendonça Mark Miranda de , Costa Wando Belffi da
Published: December 2019

O presente trabalho objetivou evidenciar, sob a perspectiva dos gestores, qual a relevância atribuída frente a o efetivo desempenho das ferramentas de custos em hotéis e pousadas localizados na cidade de Guarapari-ES. Para isso, foram abordados 41 gestores de hotéis e pousadas desta cidade, que responderam a um questionário com perguntas que objetivaram avaliar a percepção de importância atribuída e o efetivo conhecimento de ferramentas e atributos da contabilidade de custos na gestão do empreendimento que atuam. As respostas foram tratadas de maneira quantitativa e submetidas à matriz de importância-desempenho de Slack (1994; 2002). Os resultados evidenciam que a média geral de todas as respostas se encontra numa situação considerada adequada para os padrões da matriz, indicando que necessitam de manutenção para permanência nesta posição. Dessa forma, demonstram que o nível de relevância atribuída às ferramentas da contabilidade de custos é similar ao nível de desempenho, ou seja, de utilização.
RELAÇÃO ENTRE PERFIL DOCENTE E O DESEMPENHO DISCENTE DOS CURSOS DE CIÊNCIAS CONTÁBEIS
Authors: Pomerening Daniela , Kappel Rodrigo da Silveira
Published: December 2019

Este artigo tem por objetivo investigar a relação entre o perfil docente e o desempenho discente dos cursos de Ciências Contábeis. A análise da pesquisa foi desenvolvida por meio de evidências quantitativas, obtidas com base em procedimentos estatísticos de regressão linear múltipla. Objetivando maior robustez dos resultados, a avaliação da proposta central demandou a realização de cinco testes empíricos, para avaliar se as características de perfil docente apresentam relação com o desempenho dos alunos, considerando cinco critérios distintos para mensuração da variável de desempenho dos alunos. Além disso, a operacionalização dessa pesquisa demandou o levantamento e análise do perfil de 1.810 professores dos cursos de Ciências Contábeis de 85 Instituições de Ensino Superior da região Sul do Brasil, sendo mensuradas cinco variáveis independentes de perfil docente. Com relação ao desempenho discente, foram utilizados os dados dos resultados no ENADE 2015, Exame de Suficiência do CFC 2017/01, 2017/02, 2018/01 e 2018/02 (CFC, 2017; 2018). 
Nutraceuticals for Visual Performane
Authors: Erickson Graham
Published: December 2019

Eye care professionals have several
options to help athletes see their sport
better. Recent placebo-controlled
research has demonstrated that the
carotenoids lutein (L) and zeaxanthin
(Z) can improve visual performance
factors in healthy eyes. The history,
mechanisms of action, as well as
their effects and potential benefits
as shown in well-controlled trials are
reviewed. A detailed description of
how potential improvements in visual
performance may apply to batting in baseball
is provided. Recommendations for athletes
with regard to modifications of diet to increase
intake of carotenoids, or supplementation with
purified forms of L and Z are discussed.
On the Gardner Problem for the Phase-Locked Loops
Authors: Kuznetsov N. V. , Lobachev M. Y. , Yuldashev M. V. , Yuldashev R. V.
Published: December 2019

This report shows the possibilities of solving the Gardner problem of determining the lock-in range for multidimensional phase-locked loops systems. The development of analogs of classical stability criteria for the cylindrical phase space made it possible to obtain analytical estimates of the lock-in range for third-order system.
On the refined stress analysis in the applied elasticity problems accounting of gradient effects
Authors: Lomakin E. V. , Lurie S. A. , Rabinskiy L. N. , Solyaev Y. O.
Published: December 2019

The paper proposes an extension of the approaches of gradient elasticity of deformable media, which consists in using the fundamental property of solutions of the gradient theory - ​the smoothing of singular solutions of the classical theory of elasticity, converting them into a regular class not only for the problems of micromechanics, where the length scale parameter is of the order of the materials characteristic size, but for macromechanical problems. In these problems, the length scale parameter, as a rule, can be found from the macro-experiments or numerical experiments and does note have an extremely small values. It is shown, by attracting numerical three-dimensional modeling, that even one-dimensional gradient solutions make it possible to clarify the stress distribution in the constrained zones of the body and in the area of the loads application. It is shown that additional length scale parameters of the gradient theory are related with specific boundary effects and can be associated with structural geometric parameters and loading conditions that determine the features of the classical three-dimensional solution.
New method of complex photo-fluorescent microbiotesting
Authors: Sibirtsev V. S. , Garabadgiu A. V. , Shvets V. I.
Published: December 2019

The biotesting procedure is described, which provides for recording changes in the intensities of elastic light scattering, light absorption and intrinsic photofluorescence of the protein component, as well as determination of concentration and structuring coefficients of the genomic component of samples with viable unicellular test organisms, incubated in a liquid nutrient medium in the presence and absence of various external chemical factors. The results of the analysis using this technique of the antibiotic activity of cations of various metals are presented. It is shown that using this technique can be much more rapid, objectively and comprehensively than using standard visual microbiotesting methods, to assess the effect on reproduction rate, metabolic activity and genome structure of test organisms of samples of various products, wastes, etc.
PENGADILAN TINDAK PIDANA KORUPSI DAN TINDAK PIDANA PENCUCIAN UANG
Authors: Subihat Ihat
Published: December 2019

The act of corruption is a violation of every person’s life as stipulated in Article 28A of the 1945 Constitution. As a result of corruption that has been detrimental to the country’s finance or the country’s economy, it also impedes the growth and sustainability of demanding national development high efficiency. For this corruption case, a court for corruption case has been established. Meanwhile, Money Laundering as stipulated in Law No. 8 of 2010 concerning Prevention and Eradication of Money Laundering Crimes, does not have a special court but is often put together with a court of corruption. A court of corruption is the only court that has the authority to examine, hear, and decide the cases of corruption and money laundering crimes whose original crime is a criminal act of corruption; and/or criminal acts which are explicitly stated in other laws as criminal acts of corruption. The problem is how the litigation of corruption and criminal acts of money laundering are incorporated in an indictment of corruption and money laundering.

This study used the descriptive method with a normative juridical approach. Data collection was carried out through library studies by collecting data in the form of legal materials; primary, secondary and tertiary legal materials. The analysis technique of this study was descriptive analysis that analyze the process and institutions based on legislation.

The results of this study showed that the Corruption Eradication Act regulates materially and formally, so there are exceptions to the principles that are generally regulated in the Criminal Code (KUHP), Criminal Procedure Code (KUHAP) (Lex Specialist Derogate lex Generalis). The modes of money laundering are carried out in various ways. Judging from TPPU modes, it seemed true that TPPU is a stand-alone crime when using cumulative charges is more appropriate. The legal policy of the Corruption Crime Act and Money Laundering Lay (TPPU) related to the rule of law which is the basis of legality for Beneficial Ownership Criminal Liability (BO) as well as its position in Deelneming theory is a topic that must be formulated n the Action Bill Criminal Crime and Money Laundering Crime Bill (TPPU), whether effective evidence for Beneficial Owners (BO), doctrinal or the teaching snares. In the future politics of law enforcement in eradicating corruption and TPPU leads to Beneficial Ownerds (BO) is not enough as long as only the physical actors or stop at the actors revealed in the investigation. Besides the beneficial owner, it is also necessary to regulate criminal liability for legal entities that are used to save the proceeds of money laundering
PERANAN HUKUM DALAM PENGEMBANGAN INDUSTRI PERTAHANAN SEBAGAI INDUSTRI STRATEGIS DIDALAM MENJAGA KEDAULATAN NEGARA KESATUAN REPUBLIK INDONESIA
Authors: Purnamasari Faujura Rahamanisa
Published: December 2019

Indonesia's geographical located between two continents and oceans, those are the Asian nd the Australian Continent, and the Indian and the Pacific Ocean, has made Indonesia to become a country with strategic position, both for the world trade route and inter-State relations. But on the other hand Indonesia has the sovereignty of the State that must be guarded and maintained from all kinds of threats both from within and outside. For this reason, Indonesia is required to have the capacity in the form of TNI defense equipment, which is adequate as the main instrument to protect territorial sovereignty and to safeguard national interests from the threats, challenges, obstacles and disturbances both from domestic and foreign. Therefore, the development of the defense industry is also needed. The main problem in this study is how does the law regulate the development of defense industry as Indonesia's strategic industry?The descriptive method of analysis with normative juridical was used in analyzing the problems of the development of the defense industry in facing the challenges, threats, and disruptions to the Republic of Indonesia's sovereignty as a consequence of the strategic location of Indonesia's geographical position.

The results of the study show that the defense industry has a position as a strategic industry, because the primary weaponry defense system has important role in order to maintain the sovereignty of the State. Even though the regulation has been assigned in a law, namely Law Number 16 of 2012 concerning on the Defense Industry, but it has not been regulated by clear regulations and is tend to ad hoc, which is certainly not beneficial for the growth and development of the National defense industry. Law as a medium of renewing society must be able to make changes, so that it can direct where the national defense industry will be developed, so it is able to create companies that are reliable in producing defense equipment to preserve national sovereignty.
PROBLEMATIKA PENEGAKAN HUKUM DAN NAWACITA JOKOWI-JK DALAM PERSPEKTIF HUKUM TATA NEGARA DI INDONESIA
Authors: Sugianto Sugianto
Published: December 2019

“Nawacita” and Constitutional Law needs to be a legal approach to make improvements to the legal system, in order to encourage enforcement of the law with justice, then at least have to involve three pillars consisting of: (1) the substantive law (legal substance), which include legislative reform; (2) legal structure (law structure), including human resources law-enforcement officers (human resource), entered in it anyway coordination among law enforcement officers; and (3) the legal culture (legal culture), both culture and public law enforcement officers or citizens in general. Then, constitutional law and can be answered correctly, can be practiced within their Constitutional Act and may be unenforceable government in running the government. The key factor to keep in mind, eliminating egosektoral government agencies. Do not stop until the Act, a similar effort was also made to the laws which are in the executive area, such as government regulations, a presidential decree and ministerial regulation
Potensi Perlindungan Terhadap Ilmu Pengetahuan dan Teknologi oleh Dosen di Perguruan Tinggi dalam Peningkatan Daya Saing Global
Authors: Sudjana Sudjana
Published: December 2019

This study discusses the potential of Intellectual Property protection on the creation of Science and Technology Development results by Lecturers in Higher Education and Intellectual Property Protection on the Creation of Science and Technology Development results in Universities in Improving Global Competitiveness.This study is a legal research using a normative juridical approach and descriptive analytical research specifications. The data used in this study are secondary data consisting of primary, secondary and tertiary legal materials. Data obtained through library studies and field research in the form of legislation, books, journals, and authoritative electronic media.

The results of the study show that (1). the results of Science and Technology Development by university lecturers have the potential to obtain wealth protection in the field of Copyright and Patents, but do not rule out rights through other types of Intellectual Property. (2). Creation of Science and Technology development results that are protected by Intellectual Property and supported by the value chain and competitive scope will have high quality and reputation so as to enhance global competitiveness.
PAHAM KEDAULATAN NEGARA DITINJAU DARI SIFAT UNIVERSILATAS HUKUM INTERNASIONAL
Authors: Sumartini Siti
Published: December 2019

The power of theories regarding the principle of sovereignty and equality of the state began to diminish. Every independent country is a sovereign country. they are free to make policies to regulate the economic, political, legal and other systems within their country, however, today's development experiences a shift in meaning, what was previously the authority or full sovereign action of a country has diminished its understanding when the interests of other countries are disrupted or international needs require state sovereignty to be subject to universal rules and highest norms (erga omnes). In this study using a normative juridical approach and descriptive analytical research specifications. The data used in this study are secondary data consisting of primary, secondary and tertiary legal materials. Data obtained through library studies in the form of legislation, books, journals, and authoritative electronic media. The results of this study are 2 (two) explanations, namely First. that state sovereignty does not conflict with the international legal system, that state sovereignty can be used in the framework of forming an international legal system. Secondly, the universality of international law provides restrictions on the sovereignty of the state to be applied properly and the principle of respecting universal values ​​in order to maintain human dignity and their life.
ARAH PEMBAHARUAN HUKUM NASIONAL DALAM MENGHADAPI ERA REVOLUSI INDUSTRI 4.0
Authors: Suratno Ujang
Published: December 2019

Indonesia has some varieties of ethnic groups that are rich in diversity of intellectual property, there are so many products produced by society. The society creations especially created by the community are assorted, one of them is Paoman Batik. Thre are two kinds of Paoman Batik, those are contemporary and traditional, which is distinguished by its motives, processes, creators. The Paoman Traditional Batik is well-known to the public than contemporary. This research has supported the creators or copyright holders to get higher benefits, both the benefits of moral and economic rights. The main problem is, first, is the current intellectual property rights regime able to provide the foundation for the protection of Paoman Traditional Batik? Second, is the UNESCO's determination that stated if batik is a world heritage, non-object from Indonesia, can be used as the foundation to charge the economic rights of Paoman Traditional Batik? Third, is it possible for Traditional Batik, including Paoman Traditional Batik, to be carried out through other regimes, in addition to the intellectual property regime? Fourth, how is the effect of Paoman Traditional Batik Registered at the Directorate General of Intellectual Property of Indonesia on the Progress of Indramayu society?

The research method used is descriptive specification, by using juridical empirical approach, which focus on secondary research consisting of legal materials, both primary, secondary and tertiary. However it is supported by primary data generated from field research through in-depth interview and survey techniques. The analysis used is descriptive analysis.

The results of the study show that intellectual property rights that is copyright cannot be made as the foundation of protection against the creation of society that have traditional and communal motives, including the Paoman Tradsional Batik. The establishment of Batik by UNESCO as a non-object world heritage from Indonesia has increased the moral rights of Indonesia, but it also cannot be established as the foundation for restoring economic rights when there is a misappropriation. Another alternative to intellectual property is through the Sui Generis regime, which specifically addresses the protection of community rights, including intellectual property rights.
Global Behavior of Two Rational Third Order Difference Equations
Authors: ABO-ZEİD R. , KAMAL H.
Published: December 2019

In this paper, we solve and study the global behavior of all admissible solutions of  the two difference equations $$x_{n+1}=\frac{x_{n}x_{n-2}}{x_{n-1}-x_{n-2}}, \quad n=0,1,...,$$ and $$x_{n+1}=\frac{x_{n}x_{n-2}}{-x_{n-1}+x_{n-2}}, \quad n=0,1,...,$$ where  the initial values $x_{-2}$, $x_{-1}$, $x_{0}$ are real numbers.\\ We show that every admissible solution for the first equation converges to zero. For the other equation, we show that every admissible solution is periodic with prime period  six.  Finally we give some illustrative examples.
Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB4 leukemia cells via down-regulation of BIRC5 expression
Authors: Dehghan Nayeri M.J. , Mahdavi M. , Fazeli H. , Hosseinpour Feizi M.A.
Published: December 2019

Summary. Aim: It has been reported that spiroaminopyrimidine derivatives inhibited the growth and proliferation of various cancer cell lines. In the present study, we evaluated cytotoxic and apoptosis-inducing effects of 2,4-diamino-1,3-diazaspiro[5.5]-9-tert-butyl-2, 4-diene-5-carbonitril (9-tBAP) on NB4 acute promyelocytic leukemia (APL) cells. Materials and Methods: The cells were treated with 10–100 µM of 9-tBAP. Cytotoxic activity of the compound was measured using the MTT assay. Apoptosis was investigated by Hoechst 33258 staining as well as by Annexin V/PI double staining. Results: The compound under study was found to be highly active cell growth inhibitor with IC50 of 30.0 ± 3.5 µM inducing apoptosis in NB4 cells. Cell cycle analysis by flow cytometry showed a time-dependent increase in sub-G1 cell population. Real-time polymerase chain reaction analysis revealed that the treatment with the compound down-regulated the BIRC5 expression in a time-dependent manner. Conclusion: 9-tBAP displayed potent anti-leukemic activity in vitro thus warranting further investigation.
Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer
Authors: Burlaka A.P. , Burlaka А.А. , Virko S.V. , Ganusevich І. І.
Published: December 2019

Summary. Background: Interaction between tumor cells and tumor microenvironment is critical for homeostasis of normal cells and tumor growth. Tumor cell — stroma interaction represents the potent factor able to initiate cancer and affect tumor progression and disease outcome. The tumors vary by their origin and microenvironment (proportion of stromal cells, their composition and activation state). The surgical stress and tumor microenvironment may potentiate acute hepatic failure in the patients with metastatic colorectal cancer (mCRC). Pathological effect of ischemia-reperfusion (I/R) consists in the increased generation of superoxide radicals (SR) and nitrogen oxide (NO) affecting the postresectional regeneration of liver tissue. Redox state of hepatic tissue in I/R setting upon resection of metastases may trigger the aggressiveness of residual cancer cells and regeneration or degradation of hepatic tissue. The aim of the study was to analyze redox state of hepatic tissue following surgery with Pringle maneuver (PM) in the patients with mCRC. Materials and Methods: mCRC samples from 145 patients treated at National Cancer Institute, Ministry of Health of Ukraine, were analyzed. The patients obtained chemotherapy according to the approved international and national standards as well as clinical protocols. Two groups of patients were delineated according to the duration of the interruption of blood inflow due to PM, namely ≤ 45 min and > 45 min. The activity of FeS proteins in the electron transport chain (ETC) in mitochondria and lactoferrin (LF) level in the tissues were assessed by EPR (77К). The rates of SR and NO generation were determined with spin traps. The activity of matrix metalloproteinase (MMP)-2 and -9 was measured by gelatin zymography using SDS-polyacrylamide gel electrophoresis. Results: In tissue of liver resected in the setting of > 45 min ischemia, ETC function in mitochondria was impaired (decreased activity of FeS protein of N-2 ETC complex I due to interaction with NO). This results in the hypoxia state and glycolysis with uncontrolled SR generation. In addition, the efficiency of detoxification system in hepatocytes is reduced substantially with increase in semiquinone and LF levels as well as MMP-2 and -9 activity as compared with liver without metastatic lesions that was not affected by I/R. Conclusions: The ischemic injury of liver in the setting of metastasis resection results from cell response to interruption of blood flow followed by reperfusion. The key factor in the genesis of reperfusion damage is uncontrolled increase of the levels of SR and their metabolites — reactive oxygen species as well as the increased MMP activity. Also, liver tissue affected by I/R contains high levels of xanthine oxidase metabolizing hypoxanthine and monoamine oxidase deaminizing biogenic amines. Both processes are the sources of SR.
Association between XPO5 rs11077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 8511 controls
Authors: Moazeni-Roodi A. , Taheri M. , Hashemi M.
Published: December 2019

Summary. Aim: Several studies evaluated the association between rs11077 polymorphism located in the 3’UTR of the XPO5 gene and cancer susceptibility. We conducted a meta-analysis to assess the impact of XPO5 rs11077 polymorphism on cancer risk. Materials and Methods: The online databases were searched for relevant case-control studies published up to July 2018. 15 articles of 16 studies, with totally 7284 cancer cases and 8511 healthy controls, were eligible for inclusion in the meta-analysis. The data were extracted from the eligible studies and were processed using Stata 14.1 and Revman 5.3 software. Pooled estimates of odds ratio with 95% confidence intervals were used to evaluate the strength of association between XPO5 rs11077 and cancer risk. Results: Overall, our finding showed no significant association between XPO5 rs11077 variant and overall cancer risk, either performed subgroup analysis by cancer types and ethnic groups in all genetic model. Conclusion: The findings did not support an association between rs11077 variant and cancer risk. Due to small sample sizes particularly in stratified analysis, further large-scale well designed studies between this polymorphism and cancer risk are warranted.
Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392
Authors: Woksepp H. , Saini R.K.R. , Zakharchenko O. , Gautier A. , Souchelnytskyi N. , Souchelnytskyi S.
Published: December 2019

Summary. Aim: Transforming growth factor β1 (TGF β1) is a potent regulator of breast tumorigenesis. It inhibits proliferation of carcinoma cells, but the strength of its inhibitory action varies for cells from benigh, non-metastatic or metastatic tumors. The aim of this work was to generate a proteome profile of TGF β1 action on non-tumorigenic human breast epithelial cells 184A1, and validate predicted involvement of casein kinase 2α (CK2α), p53 and structure-specific recognition protein-1 (SSRP1). Materials and Methods: Two-dimensional gel electrophoresis and mass spectrometry were used to identify TGF β1-regulated proteins in 184A1 human breast immortalized non-tumorigenic cells. 184A1 cells may serve as a model of benign breast neoplasia. These cells were obtained from normal mammary tissue, were immortalized but are not malignant, and were obtained from the American Type Culture Collection. The systemic analysis was performed by using the Cytoscape tool. Transfection of cells with CK2α construct and small interfering RNAs to CK2α and SSRP1 were used to assess an impact of CK2α and SSRP1 on phosphorylation of the p53 and cell proliferation. Results: Proliferation of 184A1 cells was transiently inhibited by TGF β1. We identified 100 and 47 unique proteins which changed their expression and/or 35S-incorporation, respectively, upon treatment with TGF β1 for 2 h, 8 h or 24 h. Cell proliferation, death, migration, and metabolism were among the biological regulatory processes retrieved by the network analysis as affected by the identified proteins. The network analysis suggested that TGF β1 may affect the phosphorylation of p53 at Ser392 by engaging CK2α. This was confirmed by the immunoblotting and cell proliferation assays. Conclusion: We report here the list of 147 TGF β1-regulated proteins in immortalized non-tumorigenic human breast epithelial cells, and show involvement of CK2α in the regulation of p53 Ser392 phosphorylation.
北方稻渔综合种养技术-稻田养殖成蟹技术
Authors: 刘 洪健 , 满 庆利 , 曹 永芬 , 蔺 丽丽 , 于 胜利 , 李 永利 , 张 瑞雪 , 常 悦 , 薛 加忠 , 赵 春雨 , 王 秋举
Published: December 2019

采用“双边沟+分箱式”的北方稻蟹综合种养技术模式,即“吉林模式”。水稻种植采用分箱式、边行密植、测土施肥、生物防虫害的插秧技术方法；河蟹养殖采取双边沟,早暂养、早入稻田、早投饵,做好田间工程、稀放精养、测水调控、生态防病等技术措施；稻蟹共养,土地资源得到充分利用,可实现优质稻米550千克/亩,河蟹15.1千克/亩；河蟹平均规格达到75克/只以上,稻蟹亩综合效益达到2120元/亩,农药和化肥使用量减少40%以上。取得了较好的经济效益、生态效益和社会效益。
推进产业发展 助力乡村振兴
Authors: 谭 玲惠
Published: December 2019

习近平总书记在党的十九大报告中首次提出实施乡村振兴战略,并为农村发展描绘了“产业兴旺、生态宜居、乡风文明、治理有效、生活富裕”的蓝图。某县某乡坚持从自身实际出发,深度调整产业结构,持续优化产业布局,目前已形成以“中蜂+中药材”主导的一产,以“水”主题的二产,以“地质公园+民宿”支撑三产已初具雏形。笔者对此进行了深入调研,分析了存在的问题,并提出了几点粗浅的建议,以期让产业发展为乡村振兴赋力,建设美丽富裕的新农村。
广元市昭化区稻渔综合种养发展现状及对策
Authors: 苟 元林
Published: December 2019

该文介绍了广元市昭化区稻渔综合种养发展的现状,根据昭化区稻渔综合种养产业的实际,提出了相应的发展对策,以期加快全区乃至全市稻渔综合种养产业的发展。
现代园林景观设计与园艺技术的结合
Authors: 姜 彩英
Published: December 2019

建筑行业的发展极大地推动了园林景观设计的进步,同时园林景观设计也成为了人们关注的焦点。当前园林景观设计技术明显增多,只有园林景观设计满足时代发展需求,才能推动社会的进步。而园林技术与园艺景观设计的结合,则极大地促进了我国园林景观设计和建设的持续前行。
园林绿化养护管理在园林绿化工程中的重要性
Authors: 越 雪峰
Published: December 2019

现代城市的建设促进了中国园林绿化的发展,当今的园林工程已经成为了城市建设重点。现如今,随着人们对城市生态环境的要求越来越高,必须加强景观美化保护的管理。从园林绿化工程特点分析,园林绿化工程具备施工中间环节多、涉及面广、施工周期长等特点。基于此,为了能够全面提高绿化工程施工质量,我们就必须要能够做好园林绿化养护管理工作,抓住每个绿化施工细节,提高植被生长效率、保障植被配置的合理性,这样才能够能全面发挥园林绿化工程的经济效益和社会效益。
园林绿化设计中植物造景的作用与艺术手法
Authors: 武 文
Published: December 2019

随着中国国民经济的持续快速发展和城市化进程的加快,人们越来越重视环境问题。随着城市的发展,园林绿化的设计也在不断完善,植物的设计和艺术技巧也更加专业。植物园林绿化在园林绿化设计中起着重要作用,园林绿化艺术技术的创新应用对于提高园林绿化效果,更好地满足人们的需求具有重要意义。
浅析乡镇农机推广机构的建设与管理
Authors: 柴 立泗
Published: December 2019

系统阐述了乡镇农机推广机构的作用,具体分析了乡镇农机推广机构的建设与管理,指出基层农机推广存在的不足及破解难题的思路和建议。
贵州施秉白云岩喀斯特土壤动态变化研究
Authors: 高 洋 , 翁 应芳 , 袁 成军
Published: December 2019

本研究以贵州施秉白云岩喀斯特为研究区,为了研究白云岩喀斯特地区土壤动态变化特征,利用统计方法对研究区土壤数据进行分析。结果表明：(1)白云岩和石灰岩的交接地带的土壤偏酸性,核心区周围呈弱碱性；(2)缓冲区的土壤有机碳较核心区的低；(3)全氮、全钾北部高于南部,全磷是缓冲区高于核心区。本研究揭示了研究区的土壤pH、SOC、TN、TP、TK核心区比缓冲区稳定,人类活动对土壤养分含量的变化影响较为明显。
前郭光电式日照计与人工日照观测的对比分析
Authors: 张 磊 , 丛 宇辰 , 陆 晓平
Published: December 2019

本文利用前郭县气象局2019年4月1日-6月30日两种观测方式日照数据,对数据完整性、数据一致性进行了分析讨论,结论如下：前郭国家基本气象站的光电式数字日照计的数据完整性较好、小时数据一致性较好、全天数据一致性较好,自动观测总的趋势大于人工观测日照时数。
关于转基因食品的安全问题研究分析
Authors: 伍 有生
Published: December 2019

美国是转基因食品食用最普遍的国家,也是产量最多的国家,通常其出售转基因食品是不需要标注的(而我国民众对转基因食品都有莫名的恐惧感)。按道理讲,美国是对科学论证最严谨的国家之一,无论对转基因研究实践,还是食用转基因食品都是最早的,最少也有二十多年。如果不安全,则早就应该有研究成果或普遍事例证明。然而,恰恰相反,有许多强有力的科学证据或事实证明转基因食品是安全的。
园林绿化施工与养护管理的措施分析
Authors: 郑 会信
Published: December 2019

园林对于人们缓解压力、放松心情、提高生活质量、树立良好城市形象方面起到了很关键的作用,因此,园林绿化养护工作也显得格外重要。在很多园林建设中,由于没有进行很好的养护,导致草地退化、树木死亡和杂草丛生,严重影响了园林景观的美感。本文通过对园林绿化施工与养护管理技术进行探究,为相关工作的开展提供参考。
乡村振兴进程中耕地撂荒问题实证浅析
Authors: 成 福真
Published: December 2019

土地是农村人民赖以生存的重要资源,但也是逐年减少的有限资源。我国政府为了调动农民耕田积极性,制定了很多惠民政策,如取消农业税,粮种补贴以及农机具补贴等政策。但是随着土地面积的减少,外出务工人员的增加以及农产品价格等因素影响,导致耕地撂荒问题越来越严重。耕地撂荒的出现,加剧了土地干旱,瘠薄以及盐碱的程度。也严重的影响了土地质量,使好地变成了差地,加速了水土流失,也严重的影响了粮食安全。如果任由土地撂荒问题肆意发展,势必会对农村土地承包关系造成影响,也会影响农村生活的稳定,所以有关政府部门必须重视这个问题。
农业经济可持续发展的问题探究
Authors: 陈 连海
Published: December 2019

我国是一个农业大国,农业是社会各项活动的基础保障,在国家经济体制中占据重要组成部分,在推动农村经济发展中发挥着重要作用。探索农业经济可持续发展之路径,不仅是我国农业发展之需要,更是我国经济发展之根本实现路径。本文就农业经济可持续发展的问题进行分析研究,希望可以为农业经济的发展提供借鉴。
林业病虫害防治技术与方法探究
Authors: 李 宏超
Published: December 2019

近几年我国的林业规模逐渐增大,同时伴随着我国林业树种病虫害的发生现象严重化,很大程度的影响了林业的工作进程,为了缓解病虫害现象的严重化,本文对林业树种病虫害发生的主要因素进行探究,对黑绒金龟子、杨毒蛾、青杨天牛、天幕毛虫等病虫害防治技术应用的分析,促进造林工作的发展。
Programa de desarrollo fonológico en las habilidades para el aprendizaje de la lectura en niños de cinco años
Authors: Sito Justiniano Luz Marina , Vargas Quispe Guillermo
Published: December 2019

Se presenta un estudio cuyo objetivo fue identificar los efectos que produce la aplicación de un programa para el desarrollo fonológico en las habilidades para el aprendizaje de la lectura en niños de cinco años. El diseño es cuasiexperimental y longitudinal, la muestra consta de 35 niños y niñas de 5 años. Los instrumentos de recolección de datos fueron el Start of Reading Battery (BIL 3-6) de Pilar Sellés Nohales, Tomás Martínez Giménez y Eduardo Vidal-Abarca- Universidad de Valencia (2010), el registro sociodemográfico, el programa de asistencia y el programa para el desarrollo fonológico. La aplicación del programa tuvo una duración de seis meses y los resultados muestran que tiene un efecto positivo y significativo en las habilidades de lectura de los niños, por lo que se concluye que el entrenamiento constante del niño en el aspecto fonológico lleva a mejorar las habilidades en el aprendizaje de la lectura y las habilidades lectoras se modifican positivamente debido a la aplicación del programa de desarrollo fonológico siendo las más significativas el desarrollo del lenguaje, las habilidades metalingüísticas y los procesos cognitivos básicos.
Efectos de la capacitación y la retroalimentación sobre el plagio académico en estudiantes de Bachillerato
Authors: Arce Dariel Diaz , Brito González José Luis , Nieto Trelles Valeria Alexandra , Muñoz Arévalo Wilson David
Published: December 2019

El plagio académico es un problema que afecta a estudiantes de todos los niveles de enseñanza. El presente trabajo tuvo como objetivo evaluar la utilidad de un programa de capacitación y retroalimentación sobre la disminución del plagio  académico en estudiantes de bachillerato. Se diseñó un estudio cuasiexperimental con una muestra de 61 estudiantes de bachillerato. Se establecieron sesiones de capacitación al inicio del año lectivo y posteriormente se recibieron durante el año cuatro trabajos académicos, cada uno de los cuales fue retroalimentado y evaluado para detectar diferentes formas de plagio, el nivel de gravedad y las mejorías observadas. Los resultados muestran una tendencia a reducir la frecuencia  de formas graves de plagio hacia el final del estudio. El 44,3% mostró signos claros de mejoría en la comprensión y aplicación de la citación y referenciado de fuentes y otro 29,5% se mantuvo sin ninguna forma de plagio desde el inicio del curso. Hubo diferencias significativas en las mejorías observadas dependiendo del sexo y el rendimiento académico. Se concluye que la estrategia planteada puede ayudar a disminuir la frecuencia de plagio académico entre los estudiantes de bachillerato. Se recomiendas nuevos estudios experimentales en los que se puedan controlar más variables y observar la fortaleza de la propuesta.
Escala de estrés percibido en estudiantes de odontología, enfermería y psicología: validez de constructo
Authors: Brito Ortíz José Félix , Nava Gómez Martha Eugenia , Juárez García Arturo
Published: December 2019

El presente documento tiene como objetivo demostrar la confiabilidad y validez de constructo de la Escala de Estrés Percibido de Cohen, Kamarak, y Mermelstein en una muestra de 537 estudiantes de las licenciaturas de odontología,  enfermería y psicología, en Baja California, México. La Escala de Estrés Percibido fue diseñada para medir el grado en que las situaciones de la vida se valoran como estresantes, y está formado por 14 ítems distribuidos en dos factores. Los resultados: en cuanto a la confiabilidad y validez de constructo de la Escala de Estrés Percibido, se presentó un adecuado nivel de confiabilidad (α=.86), y el modelo de medida presentó un ajuste adecuado: GFI=.91, RMSEA=.056, NFI=.97, CFI=.98, IFI=.98. Conclusiones: Los puntajes de la escala de estrés percibido son válidos y confiables en la muestra estudiada. Sería conveniente replicar la aplicación de este instrumento con otros participantes en diferentes latitudes de México que corroboren la validez y confiabilidad obtenidas.
Propiedades psicométricas del instrumento Autopercepción del Estado Emocional (APEEM)
Authors: Piñeyro Diego , Azzollini Susana , Simkin Hugo , Herrera Álvarez Angela María
Published: December 2019

Existen diferentes técnicas para evaluar los niveles de estrés y ansiedad que una persona puede experimentar en un momento determinado (Olivares Rodríguez & Mendez Carrillo, 1997; Spielberger, Gorsuch, & Lushene, 2008). Sin embargo, son escasos o inexistentes los instrumentos que evalúan el estado de perturbación emocional (Shapiro, 2004) provocado por el recuerdo de una vivencia estresante, que cuenten con una adecuada validez y confiablidad. En el presente estudio se busca establecer las propiedades psicométricas de la técnica “Autopercepción del Estado Emocional” (Piñeyro & Azzollini, 2016; Piñeyro, 2018), la cual evalúa el impacto emocional generado por el recuerdo específico de una vivencia estresante reciente. Se evaluó una población compuesta por 81 rescatistas peruanos y bolivianos, en los días inmediatos a la ocurrencia de un desastre natural. Se realizó un Análisis de Componentes Principales y un posterior Análisis Confirmatorio. Los resultados indican que el instrumento, para su escala resumida del factor perturbación emocional, posee una estructura compuesta por 2 dimensiones: Reactividad Ansiosa Predominantemente Cognitiva y Reactividad Ansiosa Predominantemente Fisiológica, las cuales explican el 73.6% de la varianza, con una validez de constructo cuyo modelo se ajusta satisfactoriamente (Chi-cuadrado X2= 12.0034; 13gl; p=0.527; χ² / gl = 0.923 ; RMSEA = 0.000, IC 90% [0.000, 0.103]; CFI = 0.999; NFI = 0.966; NNFI = 0.999), y una muy buena fiabilidad por consistencia interna (Alfa de Cronbach= 0.88).
TINGKAT KEPUASAN LAYANAN PENDIDIKAN MAHASISWA DAN ALUMNI FITK UIN SYARIF HIDAYATULLAH JAKARTA
Authors: Anasy Zaharil , Fauzan Fauzan , Jatmiko M Anang
Published: December 2019

Penelitian ini bertujuan untuk mengetahui kepuasan mahasiswa dan alumni terhadap layanan pendidikan FITK UIN Syarif Hidayatullah Jakarta. Penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Populasi penelitian ini adalah mahasiswa angkatan tahun 2014-2017 FITK UIN Syarif Hidayatullah Jakarta. Teknik pengambilan sampel dilakukan secara propotionate stratified random sampling. Ukuran sampel sebanyak 354 orang mahasiswa dan 273 orang alumni. Teknik pengumpulan data menggunakan skala sikap. Teknik analisis data menggunakan uji kecenderungan dan persentase distribusi frekuensi. Hasil Penelitian ini menunjukkan: 1) Layanan pendidikan bagi mahasiswa dilingkungan Fakultas Ilmu Tarbiyah dan Keguruan (FITK) UIN Syarif Hidayatullah Jakarta secara umum sudah baik. Hasil tersebut ditunjukan dengan analisis angket pada 46 pernyataan yang sebagian besar masuk dalam katagori sangat puas. Kemudian hasil persentase kepuasan mahasiswa terhadap layanan pendidikan yang juga memiliki nilai 85.71% atau dalam katagori sangat puas, 2) Layanan pendidikan menurut alumni dilingkungan Fakultas Ilmu Tarbiyah dan Keguruan (FITK) UIN Syarif Hidayatullah Jakarta secara umum sudah baik. Hasil tersebut ditunjukan dengan analisis angket pada 46 pernyataan yang sebagian besar masuk dalam katagori sangat puas. Kemudian hasil persentase kepuasan alumni terhadap layanan pendidikan yang juga memiliki nilai 85.58% atau dalam katagori sangat puas.
Multikulturalisme dan Inklusi Sosial di Indonesia dalam Perspektif Historiografi
Authors: Bambang Purwanto
Published: December 2019

Dalam perkembangannya sejak tahun 1960-an hingga kini, makna dan ruang lingkup multikulturalisme tetap masih terus diperdebatkan sebagai sebuah konsep. Secara umum multikulturalisme mengacu pada pengakuan terhadap keanekaragaman dan perbedaan yang hidup dalam kesetaraan secara harmonis dan bermartabat. Diskursus tentang konsep multikulturalisme dengan berbagai konsep tandingan seperti multietnik, multi agama, intercultural dll. terkait erat dengan keadaan sosi-kultural masyarakatnya. Dalam mengulas soalan ini perspektif historiografi. Dalam perspektif historiografi multikulturalisme dan inklusi social di Indonesia tidak terlepas dari pengaruh dikhotomi internal dan beban masa lalu yang menjadi warisan kolonialisme di Indonesia.

 

Since the 1960s until now, the meaning and scope of multiculturalism continues to be debated as a concept. In general, multiculturalism refers to the recognition of diversity and differences that live in equality in a harmonious and dignified manner. Discourse on the concept of multiculturalism with various counter concepts such as multi-ethnic, multi-religious, intercultural etc. closely related to the socio-cultural state of the community. In reviewing this question historiography perspective. In the perspective of multiculturalism historiography and social inclusion in Indonesia is inseparable from the influence of the internal dichotomy and the past burden, which is the legacy of colonialism in Indonesia.
Miscellaneous Exogenous Hormones and Breast Diseases: A Matter of Concern for the Gynecologist
Authors: Alipour Sadaf , Eskandari Amirhossein
Published: December 2019

Background: The effect of exogenous sex hormones on the risk of breast cancer has been shown for some compounds but for other compounds it is under detailed investigation. This study, as part of a quadruple of articles reviewing the consequences of using sex hormones in women with various breast conditions, discusses the prescription of non-oral hormonal contraceptives and miscellaneous exogenous steroid hormones.

Methods: We browsed international clinical guidelines and carried out a comprehensive search in the literature by relevant keywords in order to extract data about the effects of hormone-releasing intrauterine devices, injectable depot-medroxyprogesterone acetate, contraceptive implants, cyproterone acetate, finasteride, and spironolactone on the breast.

Results: Studies are scarce for most of these compounds, and information comes mainly from researches about oral contraceptives and hormone replacement therapy. Although none is recommended for use in patients with breast cancer, administration in benign disorders of the breast, women with positive family history of breast cancer and general women is acceptable with minor risks.

Conclusions: Most non-oral hormonal methods of contraception and miscellaneous available hormone compounds prescribed for the treatment of hormonal disorders are safe for temporary use, except for women with breast cancer. For them, analogues of gonadotropin-releasing hormones may be considered a safe hormonal prescription.
KONSEP PERLINDUNGAN HUKUM TERHADAP WALI AMANAT DI PASAR MODAL
Authors: Pakpahan Elvira Fitriyani , Simbolon Tyson Terbit , Lovano Fibert , Elisah Elisah , Thomasia Giovanni
Published: December 2019

Wali amanat berperan sebagai pihak yang mewakili kepentingan pemegang obligasi Emiten setelah dinyatakan efektif pernyataan pendaftarannya mempunyai kewajiban untuk selalu menyampaikan informasi penting yang berbentuk laporan berkala dan laporan kejadian penting. Selain perjanjian perwaliamanatan, salah satu hal yang sangat penting bagi perlindungan kepada pemegang obligasi dari aspek hukum adalah keterbukaan informasi. Keterbukaan informasi ini merupakan jiwa dari keterbukaan pasar modal. Adapun permasalahan diajukan dalam penelitian ini adalah konsep perlindungan hukum terhadap wali amanat di Pasar Modal. Metode penelitian bersifat penelitian deskriptif dan Analisis data digunakan adalah pendekatan kualitatif. Berdasarkan hasil penelitian bahwa bentuk Perlindungan hukum bagi wali amanat menurut Undang-Undang Nomor 8 Tahun 1995 Tentang Pasar Modal dan Undang Undang Nomor 21 Tahun 2011 Tentang Otoritas Jasa Keuangan bersifat preventif dan represif. Perlindungan hukum bersifat preventif ditunjukkan dari ketentuan-ketentuan yang mengaruskan pembinaan, edukasi serta pengawasan dari otoritas bursa dan pengawas, sedangkan perlindungan hukum bersifat represif adanya penerapan sanksi berupa sanksi administratif sebagai ultimum remedium bagi para pihak yang melanggar aturan hukum dalam regulasi pasar modal. Lembaga yang berwenang untuk melakukan ini adalah OJK