bluuebunny/crossref_metadata_2025 huggingface dataset:
Quasi-bound states in the continuum induced by supercell coupling
Authors: Chen Yun , Guo Guanxuan , Liu Songyi , Yin Shan , Huang Wei , Zhang Wentao
Published: May 2023

In this paper, we propose what we believe to be a novel coupling mechanism for generating quasi-bound states in the continuum (quasi-BIC) in symmetrical metasurface structures. We demonstrate for the first time in theoretical predictions that supercell coupling can induce quasi-BIC(s). We utilize the coupled mode theory (CMT) to analyze the physical mechanism for the generation of quasi-bound states in such symmetrical structures, which result from our investigation of the coupling between sub-cells that are separated from supercells. We verify our theory by using both full-wave simulations and experiments.
KGW and YVO: two excellent nonlinear materials for high repetition rate infrared supercontinuum generation
Authors: Marciulionyte Vaida , Reggui Kawthar , Tamosauskas Gintaras , Dubietis Audrius
Published: May 2023

We present an experimental investigation of supercontinuum generation in potassium gadolinium tungstate (KGW) and yttrium vanadate (YVO) crystals pumped with 210 fs, 1030 nm pulses from an amplified Yb:KGW laser operating at 2 MHz repetition rate. We demonstrate that compared to commonly used sapphire and YAG, these materials possess considerably lower supercontinuum generation thresholds, produce remarkable red-shifted spectral broadenings (up to 1700 nm in YVO and up to 1900 nm in KGW) and exhibit less bulk heating due to energy deposition during filamentation process. Moreover, durable damage-free performance was observed without any translation of the sample, suggesting that KGW and YVO are excellent nonlinear materials for high repetition rate supercontinuum generation in the near and short-wave infrared spectral range.
Noise improves the association between effects of local stimulation and structural degree of brain networks
Authors: Zheng Yi , Tang Shaoting , Zheng Hongwei , Wang Xin , Liu Longzhao , Yang Yaqian , Zhen Yi , Zheng Zhiming
Published: May 2023

Stimulation to local areas remarkably affects brain activity patterns, which can be exploited to investigate neural bases of cognitive function and modify pathological brain statuses. There has been growing interest in exploring the fundamental action mechanisms of local stimulation. Nevertheless, how noise amplitude, an essential element in neural dynamics, influences stimulation-induced brain states remains unknown. Here, we systematically examine the effects of local stimulation by using a large-scale biophysical model under different combinations of noise amplitudes and stimulation sites. We demonstrate that noise amplitude nonlinearly and heterogeneously tunes the stimulation effects from both regional and network perspectives. Furthermore, by incorporating the role of the anatomical network, we show that the peak frequencies of unstimulated areas at different stimulation sites averaged across noise amplitudes are highly positively related to structural connectivity. Crucially, the association between the overall changes in functional connectivity as well as the alterations in the constraints imposed by structural connectivity with the structural degree of stimulation sites is nonmonotonically influenced by the noise amplitude, with the association increasing in specific noise amplitude ranges. Moreover, the impacts of local stimulation of cognitive systems depend on the complex interplay between the noise amplitude and average structural degree. Overall, this work provides theoretical insights into how noise amplitude and network structure jointly modulate brain dynamics during stimulation and introduces possibilities for better predicting and controlling stimulation outcomes.
Psychological intervention for negative emotions aroused by COVID-19 pandemic in university students: A systematic review and meta-analysis
Authors: Wang Qing , An Senbo , Shao Zebin
Published: May 2023

The COVID-19 pandemic has been suggested to cause psychological problems such as anxiety, depression, panic, and insomnia. This systematic review and meta-analysis aims to assess the efficacy of psychological interventions (including CBT, DBT, and mindfulness based interventions) in reducing distressing feelings in college students during the COVID-19 pandemic. Randomized controlled trials (RCTs) on psychological interventions for reducing negative emotions among college students during the COVID-19 epidemic were searched in databases Web of Science, PubMed, Cochrane Library, Embase, Scopus, PsychInfo, CNKI, WanFang, and VIP. We utilized Cochrane risk of bias assessment technique to assess the quality of included RCTs. The data were analyzed using RevMan 5.4. Eight RCTs were finally included involving 1,496 participants. According to the meta-analysis results, psychotherapies could significantly alleviate anxiety, depression, and stress symptoms among university students, [MD = -0.98, 95%CI (-1.53, -0.43), p<0.001] [SMD = -0.47, 95%CI (-0.77, -0.16), p = 0.003] [MD = -1.53, 95%CI (-2.23, -0.83), p <0.001]. The difference in attenuation of somatization symptoms between the two groups was not statistically significant [SMD = -0.42, 95%CI (-1.41, 0.56), p = 0.40]. Psychotherapy might effectively alleviate anxiety, depression, and stress in university students caused by the COVID-19 pandemic. It could be considered the preferred strategy for reducing negative emotions and improving the quality of life of university students.
Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer’s & frontotemporal lobar degeneration patients
Authors: Gatto Rodolfo G. , Carlos Arenn F. , Reichard R. Ross , Lowe Val J. , Whitwell Jennifer L. , Josephs Keith A.
Published: May 2023

Flortaucipir (FTP) PET is a key imaging technique to evaluate tau burden indirectly. However, it appears to have greater utility for 3R+4R tau found in Alzheimer’s disease (AD), compared to other non-AD tauopathies. The purpose of this study is to determine how flortaucipir uptake links to neuropathologically determined tau burden in AD and non-AD tauopathies. We identified nine individuals who had undergone antemortem tau-PET and postmortem neuropathological analyses. The cohort included three patients with low, moderate, and high AD neuropathologic changes (ADNC), five patients with a non-AD tauopathy (one Pick’s disease, three progressive supranuclear palsies, and one globular glial tauopathy), and one control without ADNC. We compared regional flortaucipir PET uptake with tau burden using an anti-AT8 antibody. There was a very good correlation between flortaucipir uptake and tau burden in those with ADNC although, in one ADNC patient, flortaucipir uptake and tau burden did not match due to the presence of argyrophilic grains disease. Non-AD patients showed lower flortaucipir uptake globally compared to ADNC patients. In the non-AD patients, some regional associations between flortaucipir uptake and histopathological tau burden were observed. Flortaucipir uptake is strongly linked to underlying tau burden in patients with ADNC but there are instances where they do not match. On-the-other hand, flortaucipir has a limited capacity to represent histopathological tau burden in non-AD patients although there are instances where regional uptake correlates with regional tau burden. There is a definite need for the development of future generations of tau-PET ligands that can detect non-AD tau.
Pan-genome survey of the fish pathogen Yersinia ruckeri links accessory- and amplified genes to virulence
Authors: Riborg Andreas , Gulla Snorre , Fiskebeck Eve Zeyl , Ryder David , Verner-Jeffreys David W. , Colquhoun Duncan J. , Welch Timothy J.
Published: May 2023

While both virulent and putatively avirulent Yersinia ruckeri strains exist in aquaculture environments, the relationship between the distribution of virulence-associated factors and de facto pathogenicity in fish remains poorly understood. Pan-genome analysis of 18 complete genomes, representing established virulent and putatively avirulent lineages of Y. ruckeri, revealed the presence of a number of accessory genetic determinants. Further investigation of 68 draft genome assemblies revealed that the distribution of certain putative virulence factors correlated well with virulence and host-specificity. The inverse-autotransporter invasin locus yrIlm was, however, the only gene present in all virulent strains, while absent in lineages regarded as avirulent. Strains known to be associated with significant mortalities in salmonid aquaculture display a combination of serotype O1-LPS and yrIlm, with the well-documented highly virulent lineages, represented by MLVA clonal complexes 1 and 2, displaying duplication of the yrIlm locus. Duplication of the yrIlm locus was further found to have evolved over time in clonal complex 1, where some modern, highly virulent isolates display up to three copies.
Oxygen therapeutic window induced by myo-inositol trispyrophosphate (ITPP)–Local pO2 study in murine tumors
Authors: Krzykawska-Serda Martyna , Szczygieł Dariusz , Gaweł Szymon , Drzał Agnieszka , Szczygieł Małgorzata , Kmieć Maciej M. , Mackiewicz Andrzej , Kieda Claudine , Elas Martyna
Published: May 2023

Hypoxia, an inevitable feature of locally advanced solid tumors, has been known as an adverse prognostic factor, a driver of an aggressive phenotype, and an unfavorable factor in therapies. Myo-inositol trispyrophosphate (ITPP) is a hemoglobin modifier known to both increase O2 release and normalize microvasculature. Our goal was to measure the tumor oxygen partial pressure dynamic changes and timing of the therapeutic window after ITPP systemic administration. Two syngeneic tumor models in mice, B16 melanoma and 4T1 breast carcinoma, were used, with varying ITPP dose schedules. Tissue oxygenation level was measured over several days in situ in live animals by Electron Paramagnetic Resonance oximetry with implanted OxyChip used as a constant sensor of the local pO2 value. Both B16 and 4T1 tumors became more normoxic after ITPP treatment, with pO2 levels elevated by 10–20 mm Hg compared to the control. The increase in pO2 was either transient or sustained, and the underlying mechanism relied on shifting hypoxic tumor areas to normoxia. The effect depended on ITPP delivery intervals regarding the tumor type and growth rate. Moreover, hypoxic tumors before treatment responded better than normoxic ones. In conclusion, the ITPP-generated oxygen therapeutic window may be valuable for anti-tumor therapies requiring oxygen, such as radio-, photo- or immunotherapy. Furthermore, such a combinatory treatment can be especially beneficial for hypoxic tumors.
Targeted social marketing of PrEP and the stigmatization of black sexual minority men
Authors: Calabrese Sarah K. , Kalwicz David A. , Dovidio John F. , Rao Sharanya , Modrakovic Djordje X. , Boone Cheriko A. , Magnus Manya , Kharfen Michael , Patel Viraj V. , Zea Maria Cecilia
Published: May 2023

Disparities in HIV incidence and PrEP uptake suggest a need to prioritize Black sexual minority men (SMM) in PrEP social marketing initiatives. However, images linking Black SMM to HIV and PrEP may inadvertently reinforce stigma. We examined HIV-negative/status-unknown Black SMM’s responses to targeted PrEP advertisements using mixed methods, including an experiment embedded in a longitudinal online survey (Time 1:n= 96; Time 2 [eight weeks]:n= 73) and four focus groups (n= 18). The full factorial experiment included between-groups and within-subjects comparisons. For between-groups comparisons, each participant was randomly assigned to view one of 12 advertisements, which varied by couple composition (Black SMM couple/Black heterosexual couple/multiple diverse couples/no couples) and campaign (PrEPare for the Possibilities/PlaySure/PrEP4Love). We examined couple composition, campaign, and interaction effects on: advertisement judgments (Time 1), PrEP stigma (Time 1), PrEP motivation (Times 1 and 2), and PrEP behavior (Time 2). For within-subjects comparisons, each participant viewed all 12 advertisements, and we examined couple composition, campaign, and interaction effects on advertisement judgments (Time 2). Focus group participants discussed advertising preferences and responded to the same set of advertisements. For between-groups and within-subjects comparisons, we found significant couple composition effects but no or limited campaign and interaction effects on advertisement judgments. Advertisements featuring Black SMM exclusively were judged as more stigmatizing than advertisements without couples. Advertisements with diverse (vs. no) couples were considered more eye-catching and motivating. There were minimal effects of couple composition and campaign on PrEP stigma, motivation, and behavior. Focus group participants corroborated concerns about the potential for PrEP advertisements to be stigmatizing, suggesting advertisements featuring Black SMM exclusively could be alienating and fuel conspiracy theories. Focus group participants generally favored diverse and less sexualized advertisements, particularly for public spaces. Findings collectively highlight the potential for targeted PrEP advertisements to stigmatize Black SMM and support diverse representation.
Older patient age and prior antimicrobial use strongly predict antimicrobial resistance in Escherichia coli isolates recovered from urinary tract infections among female outpatients
Authors: Mitrani-Gold Fanny S. , Kaye Keith S. , Gupta Vikas , Mulgirigama Aruni , Trautner Barbara W. , Scangarella-Oman Nicole E. , Yu Kalvin C. , Ye Gang , Joshi Ashish V.
Published: May 2023

Background

Increasing prevalence of antimicrobial resistance (AMR), including multidrug resistance (MDR), among Escherichia coli (E. coli) makes treatment of uncomplicated urinary tract infection (uUTI) difficult. We assessed risk factors for fluoroquinolone (FQ)-not-susceptible (NS) and MDR E. coli among US female outpatients.

Methods

This retrospective cohort study utilized data from female outpatients aged ≥ 12 years with E. coli positive urine culture and oral antimicrobial prescription ± 1 day from index. We assessed patient-level factors within 90 and 91–360 days prior to index as predictors of FQ NS (intermediate/resistant) and MDR (NS to ≥ 1 drug across ≥ 3 classes) E. coli: age, prior oral antimicrobial dispensing, prior AMR phenotypes, prior urine culture, and prior hospitalization.

Results

Among 1,858 outpatients with urine-isolated E. coli, 369 (19.9%) had FQ NS and 59 (3.2%) had MDR isolates. After multivariable adjustment, independent risk factors (p < 0.03) for FQ NS E. coli were older age, prior FQ NS isolates, prior dispensing of FQ, and dispensing of any oral antibiotic. Independent risk factors (p < 0.02) for MDR were prior extended-spectrum β-lactamase-producing isolates (ESBL+), prior FQ dispensing, and prior oral antibiotic dispensing.

Conclusions

In women with uUTI due to E. coli, prior dispensing of FQ or any oral antibiotic within 90 days predicted FQ NS and MDR urine E. coli. Prior urine culture with FQ NS isolates and older age were predictive of FQ NS E. coli. Prior ESBL+ was predictive of MDR E. coli. These data could help identify patients at risk for AMR E. coli and inform empiric prescribing.
Trimethoprim-Sulfamethoxazole-associated early neutropenia in Mexican adults living with HIV: A cohort study
Authors: Jacobo-Vargas Thalia Berenice , Báez-Saldaña Renata , Cruz-Hervert Luis Pablo , Fortoul Teresa Imelda , Ahumada-Topete Victor Hugo , Rodríguez-Ganén Odalis , Vega-Barrientos Ricardo Stanley
Published: May 2023

Introduction

Trimethoprim/sulfamethoxazole (TMP/SMX) is the antimicrobial of first choice in the treatment and prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients, particularly in people living with human immunodeficiency virus (HIV). TMP/SMX use entails different adverse effects, and its association with early neutropenia is minimally documented. This study aimed to identify the risk of early neutropenia associated with TMP/SMX use in adults living with HIV in Mexico.

Methods

A prospective cohort study was conducted in TMP/SMX-naïve adults living with HIV admitted to a third-level hospital between August 2019 and March 2020. Socio-demographic, clinical, and laboratory data were collected. According to patients’ diagnostic, if they required treatment or prophylaxis against PCP, medical staff decided to prescribe TMP/SMX, as it is the first-line treatment. The risk of TMP/SMX induced early neutropenia, as well as associated factors were analyzed through a bivariate model and a multivariate Poisson regression model. The strength of association was measured by incidence rate ratio (IRR) with 95% confidence interval.

Results

57 patients were enrolled in the study, of whom 40 patients were in the TMP/SMX treatment-group for treatment or prophylaxis of PCP (204.8 person-years of observation, median 26.5 days) and 17 patients were in the non-treatment group because they did not need the drug for treatment or prophylaxis of PCP (87.0 person-years of observation, median 21 days). The incidence rate of early neutropenia in the TMP/SMX-treatment group versus non-treatment group was 7.81 and 1.15 cases per 100 person-years, respectively. After adjusting for stage 3 of HIV infection and neutrophil count <1,500 cells/mm3 at hospital admission, the current use of TMP/SMX was not associated with an increase in the incidence rate ratio of early neutropenia (adjusted IRR: 3.46; 95% CI: 0.25–47.55; p = 0.352).

Conclusions

The current use of TMP/SMX in Mexican adults living with HIV was not associated with an increase in the incidence rate ratio of early neutropenia.
Horticulture producer’s willingness to participate in contract-based supply chain coordination: A case study from Queensland (Australia)
Authors: Schrobback Peggy , Rolfe John , Akbar Delwar , Rahman Azad , Kinnear Susan , Bhattarai Surya
Published: May 2023

Product export provides an option for horticulture producers in Queensland (Australia) to diversify their market and increase returns from production. Vertical supply chain coordination in the form of contract-based marketing agreements between producers and export agents/distributors could facilitate increased export. The aim of this study was to investigate the willingness of horticulture producers to participate in export focused contract-based marketing agreements. To achieve this aim, a survey including a discrete choice experiment was conducted. The results from a mixed logit model and a latent class model suggest that there are three clusters of producers: a) the export interested, b) the likely risk averse, and c) those well established in the domestic markets. Only producers in group a) expressed a preference for contract-based export marketing agreements. These producers appear to be younger, already have some export experience, and have a relatively high level of collaboration in their product supply chains. Producers in groups b) and c) expressed an interest in stronger coordination within the domestic retail sector, potentially in the form of contract farming. Prices of produce and potential higher production costs are determinants identified by all producer groups as important for their decision-making about changes to their supply chain.
The impact of COVID-19 pandemic on key performance indicators in three Saudi hospitals
Authors: Alharbi Abeer , Almana Ranya S. , Aljuaid Mohammed
Published: May 2023

Objective

The coronavirus disease (COVID-19) disrupted healthcare systems and medical care worldwide. This study attempts to assess the performance of three Saudi hospitals during COVID-19 by comparing waiting times for outpatient appointments and the volume of elective surgeries before and after COVID-19.

Methods

We used ADA’A data collected from three Saudi hospitals for this retrospective cohort study. The outcome variables were “Waiting Time for Appointment” and “Elective OR Utilization”. The hospitals included in this study were: a 300-bed maternity and children’s hospital; a 643-bed general hospital; and a 1230-bed tertiary hospital. We included all patients who visited the OPD and OR in the time period from September 2019 to December 2021. A two-way ANOVA test was used to examine the differences in the outcome variables by hospital and by the phase of COVID-19.

Results

For the elective OR utilization rate, the results showed that both the hospital and the phase of COVID-19 were significantly different (p-value < 0.05). On average, the elective OR utilization rate dipped considerably in the early phase of COVID-19 (33.2% vs 44.9%) and jumped sharply in the later phase (50.3%). The results showed that the waiting time for OPD appointment was significantly different across hospitals and before and after COVID-19 in each hospital (p-value < 0.05). the waiting time dropped during the early phase of COVID-19 for both the general hospital (GEN) (24.6 days vs 34.8 days) and the tertiary hospital (MDC) (40.3 days vs 48.6 days), while the maternity and children’s hospital (MCH)’s score deteriorated sharply (24.6 days vs 9.5 days).

Conclusion

This study indicates that COVID-19 led to a significant impact on elective surgery rates and waiting time for OPD appointments in the early stage of the pandemic when the lockdown strategy was implemented in the country. Although the elective surgery rate had decreased at the designated COVID-hospital, the waiting time for OPD appointment had improved. This is a clear indication that the careful planning and management of resources for essential services during pandemic was effective.
Adaptation of families of adult patients with brain tumor: Partial least squares structural equation modeling
Authors: Jung Mijung , Jeong Younhee , Park Bong Jin
Published: May 2023

Brain tumor patients experience physical, psychological, social, and cognitive changes. These changes are challenging for both the patients and their families. These patients and their families need to adapt together on the cancer treatment path. This study aimed to identify the factors affecting adaptation in families of adult patients with brain tumors. A quantitative, cross-sectional study of 165 families of adult patients with primary brain tumors was conducted using a self-administered questionnaire. Partial least squares structural equation modeling was used to test a hypothetical model. The results showed that family stress, family functioning, and family resources influenced on family adaptation in families of adult patients with primary brain tumors. Among these factors, family resources were identified to be the strongest factor associated with family adaptation. The results of this study may be utilized as a theoretical basis in nursing to improve the family adaptation of patients with brain tumors. Regarding nursing practices, the results suggest that nurses should provide family-centered nursing interventions and promote family resources to help brain tumor patients and their families to adapt.
Breathing beyond borders: Reclaiming BIPOC knowledges and methodologies in drama therapy
Authors: Williams Britton , Lepere Refiloe
Published: May 2023

This editorial reflects on the urgent need for literature that reflects Black, Indigenous and People of Colour (BIPOC) theories, practices and methods. This Special Issue investigates the social and cultural contexts that support and enable decolonial practices of theorizing and healing. The authors herein experiment with different forms of resistance, imagine new research methodologies, engage collective imagination, and lift and re-cover cultural wisdom through their contributions. Calling on ancestral, cultural and embodied knowledge, the contributors to this Special Issue unsettle default assumptions and expectations regarding knowledge, theory and practice in drama therapy and beyond.
A content analysis on race in drama therapy empirical research
Authors: Lee Erica Laikah , Morris Mary Elizabeth , Rowe Chyela , Moreno Michelle , Navarro Jonathan
Published: May 2023

Drama therapy empirical research has the potential to support growth within the profession, but changes are still needed to address a lack of racially diverse perspectives represented in studies. A Black, Indigenous and People of Color (BIPOC) research sub-committee of the North American Drama Therapy Association (NADTA) was formed and members took on the task of reading full-text available articles listed in the NADTA empirical references list (N= 123) with the aim of identifying representations of race within the research through a content analysis. Our team found limited examples of both author-identified race information and contextualized participant racial demographics. When race was presented, most often as descriptive statistics alone, contextual information about culture or other relevant supportive literature was often lacking. Further research and a more systematic critical review of existing drama therapy empirical studies are needed to formulate recommendations for addressing racial disparities within drama therapy research.
Astrodrama: Exploring the use of astrological archetypes in drama therapy for Filipinos in the United States
Authors: Gamboa Monica Lopez
Published: May 2023

There is a dearth of empirical research in drama therapy integrating other disciplines, particularly with BIPOC adult populations. The present qualitative study examines the research question: what do the Filipinos in the United States experience in Astrodrama and what meaning does it offer them? Four Filipino-identified participants engaged in a virtual drama therapy protocol, Astrodrama, over the course of five weeks. Based on semi-structured individual and group interviews, this article highlights the benefits, challenges, cultural influences and engagement in the protocol.
Turbulence: Arts-based participatory action research on the experience of creative arts therapists and creatives who identify as Black and people of colour
Authors: Sajnani Nisha , Williams Britton , Yuan Low Ming , Edwards Jasmine , Dixon Saharra , Stevens Adam D.-F. , Morris Mary , Yeung Li Si , Garcia Rodriguez Idalmis , Ikram Samah , Bell Whitney , Rodriguez Perez Carlos
Published: May 2023

Following the production of Turbulence, an original play featuring the experiences of creative arts therapists and creatives who identify as Black and people of colour (BPOC), members of the ensemble agreed to engage in an arts-based participatory action research process in which co-researchers drew on dramatic, visual, musical and poetic forms of inquiry to ask themselves about the realities and hopes faced by this community and the environmental conditions that would support their movement, growth and mobility. Findings emphasized the value and necessity of creative affinity groups together with sustainable structural, financial and relational support to encourage the hopes and dreams of BPOC students and professionals.
Pylephlebitis Complicated by Hepatic Abscesses due to Fusobacterium Nucleatum: A Case of Lemierre's Syndrome Variant and Literature Review
Authors: Jaber Fouad , Alsakarneh Saqr , Campbell John , Awad Ameen , Mohamed Wael T. , Wittler Kaitlin , Ghoz Hassan , Clarkston Wendell
Published: May 2023

In gastrointestinal-variant Lemierre syndrome, Fusobacterium nucleatum can cause pylephlebitis and liver abscesses. We report a 62-year-old woman presenting with abdominal pain and altered mental status. Abdominal computed tomography showed hepatic lesions and thrombosis in the superior mesenteric and portal veins. Magnetic resonance cholangiopancreatography showed multiple cystic hepatic masses suspicious for abscess vs metastases. Malignancy workup was unrevealing. F. nucleatum grew on both blood and ultrasound-guided liver aspirate cultures. Twelve weeks of antibiotics and anticoagulants resolved her condition. Given the high mortality rates, prompt detection and treatment of gastrointestinal-variant Lemierre syndrome is critical to delivering quality, patient-centered care.
Objetivos de desarrollo sostenible, gestión universitaria e investigación en ciencias del diseño
Authors: Terán Rojas Betzi Dianora , Polanco de Maduro Ligia , Terán Rojas Anabel , Escalona López Oswaldo
Published: May 2023

Introduction/objective: The purpose of this research is to analyze the impact of the sustainable development goals (SDG) and its application in higher education as a key element in its implementation and the same time to emphasize the importance of raising awareness of existence of these objetives for survival of humanity, since the university is an institution with a markedly social caracter, because of the influence that the generation of knowledge and technology that is projeted in the direction of institutions, organizations and countries in their evolution and progress, positively impacting society, promoting its permanence in the global and local context. The methodology is proyective, with a caological approach, is carried out in two phases: a first phase is carried out through a systematic documentary review and a second stage in the analysis of the key factors in 20 scientifics articles base on the paradiggm of design science. Results: in the sustainable development goals: indicate the problem in 5 studies (50%) it is essential to establish plans and policies for its implementation; the suggestion: Eco-efficiency is important in the activities and emphasis on environmental management with 8 (80%) studies; in university management : the problema with 7 (70%) studies it advocates that the university must increasingly achieve an education that can be perfected in the service of humanity and in relation to the suggestion : the university is an ideal setting to contribute to sustainable higher education with 6 (60%) studies. Conclusions: iniversity management must apply plans and policies design pedagogical proposals and implement them according to sustainability criteria for the good of all living beings.
Research on large deformation control technology of highly weathered carbonaceous slate tunnel
Authors: Cui Guangyao , Chen Qinlong
Published: May 2023

In order to further explore the large deformation control technology of high ground stress soft rock tunnel, this study takes the highly weathered carbonaceous shale section of Muzhailing tunnel as the research background, the large deformation control effect of scheme 1 “three-step method” and scheme 2 “pilot tunnel expansion method” are compared and analysed by field test and numerical simulation. The results show that the numerical simulation results are consistent with the field test, and the deformation trend of the tunnel is the same. The maximum deformation of the tunnel occurs at the middle step. From the perspective of tunnel deformation, control effect is reduced by about 10% compared with scheme 1, and the deformation of both schemes does not exceed the reserved deformation (400 mm). From the perspective of construction efficiency, the construction efficiency of scheme 2 is 23.07% lower than that of scheme 1. Taking into account the deformation control effect and construction efficiency, it is recommended that the three-step method should be adopted in the construction of this section, and the research results can provide a reference for the construction of the carbonaceous slate section of the tunnel.
Go-betweens and competitors. The Japanese residents in Southeast Asia at the crossroads between communities (17th century)
Authors: Bachelet Pierre-Emmanuel
Published: May 2023

During the 17th century, the unprecedented opening of Japan to the outside world drew hundreds of Japanese to travel to and settle in Southeast Asia. These Japanese residents, some of whom continued to maintain a strong connection with Japan, acquired a privileged position in their host societies, as merchants, officials, or soldiers. This position enabled them to occupy the central function of go-betweens in the relations that the Southeast Asian states sought to establish with foreign merchants. This paper aims to demonstrate, through a careful analysis of sources and the use of modeling, that the Japanese in Southeast Asia crossed borders in multiple ways. Not only did they move outside the borders of Japan, but through their role as go-betweens they were also at the interface between social, ethnolinguistic, and religious groups. They used this favorable situation to facilitate communication as well as to erect barriers, according to their own interests. Although migrants imported practices from Japan when they settled there, this paper argues that in order to understand the solidity of their settlement and the success they and their children experienced they should be seen as frontier actors rather than Japanese migrants.
Two different semiotic frameworks for viewing Japan
Authors: Hopkins John A. F.
Published: May 2023

In this paper, I would like to examine, within a semiotic framework, two contrasting views of the contemporary culture of Japan – which is still relatively little-known outside its own shores. First, there is theoutsider’s view, according to which Japan is firmly situated in the “Far East”. This is the usual interpretant of subject-sign Japan, which is taken to refer – as its object-sign – to all that isdifferentfrom the “West”: language, culture, society, manners, et cetera. In other words, this is Japan still masquerading as the “Mysterious East”. The second view of Japan is that ofinsiders: mostly ethnic Japanese – but with nearly 3 million residents of different ethnicities. Beginning in the mid-1800s, Japan set out to modernise itself. By the mid Meiji Period (1887), the government had adopted the sloganDatsu-A, Nyû-Ô, literally ‘Get out of Asia/embrace Europe’. As a result, in many areas (health care and longevity, income distribution, education, public safety, public and personal cleanliness, social politeness, respect for the law, architectural technology, precision manufacturing, and cuisine), Japan is in a league of its own. The object-signs of this newer Japan are all non-Asian aspects of Japanese culture. Their interpretant is the “Far West”.
Crystal structure of tetracene-5,12-dione, C18H10O2
Authors: Zheng Xiaoxin , Jiang Jinke , Liu Yang
Published: May 2023

C18H10O2, orthorhombic, P212121 (no. 19), a = 3.95660(10) Å, b = 12.2859(3) Å, c = 24.5014(6) Å, V = 1191.02(5) Å3, Z = 4,

R

g
t

${R}_{gt}$

(F) = 0.0609,

w

R

r
e
f

$w{R}_{ref}$

(F
2) = 0.1660, T = 302(2) K.
Crystal structure of dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b′]dithiophene-5,10-dione, C14H4O2S4
Authors: Jia Yan , Yu Pengling , Li Shihui , Zhao Yumei , Zheng Xiaoxin
Published: May 2023

C14H4O2S4, monoclinic, P21/n (no. 14), a = 3.85180(10) Å, b = 8.9728(2) Å, c = 18.0073(4) Å, β = 93.554(1)°, V = 621.16(3) Å3, Z = 2, R

gt
(F) = 0.0411, wR

ref
(F
2) = 0.1091, T = 301(2) K.
Dipeptidyl peptidase IV: a multifunctional enzyme with implications in several pathologies including cancer
Authors: Arrebola Sánchez Yarini , Almeida García Fabiola , Ojeda del Sol Daniel , Valdés-Tresanco Mario E. , Ortiz Carlos David , Sánchez Ramírez Belinda , Pascual Alonso Isel
Published: May 2023

Ectopeptidases are particularly interesting due to their potential to regulate/dysregulate the peptide mediated signaling cellular pathways because the active site located to the extracellular space. Dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) is currently one of the ectopeptidases that has a great and complex influence on important physiological and pathological processes. Due to its influence on the immune system, type 2 diabetes mellitus, pulmonary pathologies, cardiovascular system, viral infections and cancer, DPP-IV is very attractive as a possible therapeutic target. However, its versatility makes such expectations very difficult. The aim of this work is to summarize relevant structural and functional aspects of DPP-IV and the role of this protein in several pathologies with special emphasis on cancer. DPP-IV role in cancer seems to depend on specific location, histologic type of tumour, tumour microenvironment, and presence/absence of molecules able to interact with DPP-IV. Because of DPP-IV controversial effects, generalizations are difficult and most of the time the role of DPP-IV must be analyzed case by case. However, new evidences in cell lines, animal models and clinical studies suggest that DPP-IV inhibitors open a promissory window through new therapeutic strategies against some cancers.
Arousal and Locomotion Differently Modulate Activity of Somatostatin Neurons across Cortex
Authors: Khoury Christine F. , Fala Noelle G. , Runyan Caroline A.
Published: May 2023

Arousal powerfully influences cortical activity, in part by modulating local inhibitory circuits. Somatostatin (SOM)-expressing inhibitory interneurons are particularly well situated to shape local population activity in response to shifts in arousal, yet the relationship between arousal state and SOM activity has not been characterized outside of sensory cortex. To determine whether SOM activity is similarly modulated by behavioral state across different levels of the cortical processing hierarchy, we compared the behavioral modulation of SOM-expressing neurons in auditory cortex (AC), a primary sensory region, and posterior parietal cortex (PPC), an association-level region of cortex, in mice. Behavioral state modulated activity differently in AC and PPC. In PPC, transitions to high arousal were accompanied by large increases in activity across the full PPC neural population, especially in SOM neurons. In AC, arousal transitions led to more subtle changes in overall activity, as individual SOM and Non-SOM neurons could be either positively or negatively modulated during transitions to high arousal states. The coding of sensory information in population activity was enhanced during periods of high arousal in AC, but not in PPC. Our findings suggest unique relationships between activity in local circuits and arousal across cortex, which may be tailored to the roles of specific cortical regions in sensory processing or the control of behavior.
The structure of fly Teneurin‐m reveals an asymmetric self‐assembly that allows expansion into zippers
Authors: Li Jingxian , Bandekar Sumit J. , Araç Demet
Published: May 2023

Teneurins are conserved cell adhesion molecules essential for embryogenesis and neural development in animals. Key to teneurin function is the ability of its extracellular region to form homophilic interactions in cis and/or in trans. However, our molecular understanding of teneurin homophilic interaction remains largely incomplete. Here, we showed that an extracellular fragment of Teneurin‐m, the major teneurin homolog in flies, behaves as a homodimer in solution. The structure of Teneurin‐m revealed that the transthyretin‐related domain from one protomer and the β‐propeller domain from the other mediates Teneurin‐m self‐association, which is abolished by point mutation of conserved residues. Strikingly, this architecture generates an asymmetric oligomerization interface that enables expansion of Teneurin‐m into long zipper arrays reminiscent of protocadherins. An alternatively spliced site that exists only in vertebrates and regulates homophilic interaction in mammalian teneurins overlaps with the fly Teneurin‐m self‐association interface. Our work provides a molecular understanding of teneurin homophilic interaction and sheds light on its role in teneurin function throughout evolution.
Pengaruh Pembelajaran Daring Menggunakan Moodle Terhadap Hasil Belajar Pada Mata Pelajaran Tata Rias Wajah Panggung Di SMK N 3 Magelang
Authors: Ismawati Fitri Choyrotul , Marwiyah Marwiyah
Published: May 2023

Penelitian ini bertujuan untuk menganalisis pengaruh pembelajaran daring menggunakan Moodle terhadap hasil belajar pada mata pelajaran tata rias wajah panggung di SMK N 3 Magelang. Penelitian ini merupakan penelitian kuantitatif menggunakan metode eksperimen dengan desain penelitian pre-eksperiment one-group pretest-posttest design, yaitu penelitian yang hanya menggunakan satu kelompok kelas. Hasil penelitian yang diperoleh menunjukkan (1) Nilai rata-rata N-Gain score untuk pembelajaran tata rias wajah panggung menggunakan Moodle adalah sebesar 60,8% termasuk dalam kategori cukup efektif. (2) Didapatkan nilai korelasi (R) yaitu sebesar 0,649. Dari output tersebut diperoleh koefisisen determinasi sebesar 0,421 yang berarti bahwa pengaruh variabel X (Moodle) terhadap variabel Y (hasil belajar) adalah sebesar 42,1%. (3) Koefisien regresi X sebesar 0,340 menyatakan bahwa setiap penambahan 1% nilai Moodle, maka nilai hasil belajar bertambah sebesar 0,340. koefisien regresi tersebut bernilai positif, sehingga dapat disimpulkan bahwa arah pengaruh variabel X terhdap variabel Y positif.
POTENSI RUMPUT LIAR (GULMA) SEBAGAI PEWARNA ALAM BATIK SUTERA
Authors: Subositi Niken , Syamwil Rodia
Published: May 2023

Tujuan penelitian ini adalah untuk mengetahui potensi gulma sebagai pewarna alam dan memanfaatkan gulma untuk mewarnai batik dari kain sutera, serta menguji kualitas hasil pewarnaan dari aspek ketuaan warna dan ketahanan luntur warna terhadap pencucian. Penelitian ini juga bertujuan mengungkap perbedaan kualitas warna dengan mordan yang berbeda. Objek penelitian ini adalah gulma alang-alang, sembung rambat, dan rumput paitan, kain batik sutera, dan mordan tunjung, tawas, kapur tohor. Penelitian eksperimen dilakukan untuk membuat kain batik sutera dan mewarnainya dengan ekstrak gulma untuk kemudian di uji tahan luntur warna terhadap pencucian dan ketuaan warna. Hasil menunjukkan bahwa nilai tahan luntur warna terhadap pencucian rata-rata cukup baik dengan nilai 3–4, nilai ketahan luntur warna paling optimal pada ekstrak gulma alang-alang dengan menggunakan mordan tunjung nilai 4. Ketuaan warna bervariasi sesuai jenis gulma dan mordan, nilai ketuaan warna paling tinggi ditunjukkan oleh gulma rumput paitan dengan mordan tunjung nilai 82,59.
Pola Asuh Autoritatif dan Efikasi Diri pada Self-Regulated Learning Siswa Remaja
Authors: Wulandari Putu Novia Putri , Swandi Ni Luh Indah Desira
Published: May 2023

Siswa memiliki peran dalam meningkatkan mutu pendidikan dengan cara menjalankan proses belajar yang baik serta mengerjakan tugas secara mandiri dan bertanggung jawab. Ini dapat dicapai apabila siswa mempunyai kemampuan self-regulated learning (SRL), yaitu kemampuan mengatur disiplin diri saat belajar. Terdapat faktor eksternal dan internal yang mendorong SLR siswa, yaitu pola asuh autoritatif (PAA) dan efikasi diri (ED). Penelitian ini hendak mengkaji peran PAA dan ED pada SRL siswa remaja di SMA Negeri 1 Ubud secara kuantitatif. Partisipan penelitian terdiri dari 198 siswa remaja di SMA Negeri 1 Ubud, yang dipilih melalui systematic random sampling. Alat ukur penelitian terdiri dari skala self-regulated learning (SRL), skala pola asuh autoritatif (PAA), dan skala efikasi diri (ED). Analisis hasil menggunakan teknik analisis regresi berganda yang mengindikasikan adanya peran PAA dan ED pada SRL sebesar 50,4% dengan signifikansi 0,000 (p0,05). Hal ini berarti hipotesis dalam penelitian ini diterima. Secara lebih lanjut, PAA diketahui berperan secara mandiri pada SRL serta ED juga berperan mandiri pada SRL siswa remaja di SMA Negeri 1 Ubud.Students take part in improving the quality of education by studying properly and completing their tasks responsibly. These can only be achieved when students have self-regulated learning (SRL), which is the ability to discipline themselves in the activity of studying. There are external and internal factors that encourage SRL of adolescent student, which is authoritative parenting (PAA) and self-efficacy (ED). This study wants to examine the role of PAA and ED in SRL of adolescent students in SMA Negeri 1 Ubud quantitatively. The participants of this study consisted of 198 adolescent students in SMA Negeri 1 Ubud who were chosen through systematic random sampling. The instruments of this study are self-regulated learning scale, authoritative parenting scale, and self-efficacy scale. This study using multiple regression analysis technique that show the role of PAA and ED in SRL by 50.4% with a significance value is 0,000 (p 0.05). Furthermore, this study indicates that PAA independently has significant role in SRL. ED also independently has significant role in SRL of adolescent students in SMA Negeri 1 Ubud.
Глобальне громадянське суспільство в умова цифрової трансформації
Authors: Корсун Віталій
Published: May 2023

Метою  дослідження є визначення функцій глобального громадянського суспільства та його вплив на вирішення глобальних проблем в умовах цифрової трансформації  суспільства. Також предметом розгляду є взаємодія інституцій глобального громадянського суспільства з державами, їх міждержавними об'єднаннями, оскільки секторальна взаємодія на цьому рівні в умовах цифрової трансформації зазнає останнім часом помітних змін.

Відзначено "цивілізаційну" функцію глобального громадянського суспільства, оскільки останнє є суб'єктом формування нового світового порядку та сучасного гуманітарного світогляду, що ґрунтується на першості справедливості та прав людини. Розглянуто різні аспекти діяльності глобального громадянського суспільства в умовах цифровізації, як одного з головних факторів формування національного громадянського суспільства у країнах, що знаходяться у процесі трансформації – таких, як Україна.

Зроблено висновок, що  незважаючи на багато визначень та концепцій, громадянське суспільство має одне загальне розуміння як простір поза урядом, сім'єю та ринком. Це той простір, в якому окремі особи і колективні організації висувають загальні ідеї і мають спільні цілі. В умовах цифровізації, формування глобального громадянського суспільства призвело до розширення уявлень про коло учасників громадянського суспільства, як на глобальному так і на національному рівнях. Насьогодні до їх складу входять окрім неурядових організацій, також громадські рухи, групи корінних народів, благодійні та релігійні організації, оператори засобів масової комунікації (в першу чергу Інтернет, соціальні мережі тощо), наукові кола, організації діаспори, лобістські та консультаційні групи, аналітичні та дослідницькі центри, професійні асоціації та фонди. Це коло постійно розширюється як кількісно та і якісно. Навіть політичні партії і приватні компанії можуть вважатись елементами цифрового громадянського суспільства. Публічне управління в умовах цифрової трансформації все більше стає полем діяльності різноманітних глобальних інституцій та структур, які розглядаються саме як актори глобального громадянського суспільства.
Fibre and short-chain carbohydrate composition in rye varieties, novel industrial milling fractions and breads
Authors: Szentmiklóssy M.K.J. , Jaksics E. , Farkas A. , Pusztai É. , Kemény S. , Németh R. , Tömösközi S.
Published: May 2023

Rye is an important raw material of bread due to tradition and its favourable nutritional and technological qualities. Despite the beneficial fibre composition, a special group of short-chain carbohydrates, the so called FODMAPs (fermentable oligo-, di-, monosaccharides and polyols) may cause problems for patients with irritable bowel syndrome. The aim of our work was to investigate the non-starch carbohydrate (dietary fibre compounds, short-chain carbohydrates) composition of rye varieties, and of their novel milling fractions obtained from industrial milling trials and test loaves made from them. Regarding fibre and short chain carbohydrate composition, rye varieties did not show significant differences. In new subfractions, fibre and FODMAP composition were described, among profiles most of them differ from commonly used flours, independently from variety. The yeast fermentation and baking caused a decrease in water-extractable arabinoxylan content, at the same time increased the substitution pattern of water-extractable arabinoxylans. Furthermore, breadmaking process decreased the fructan content, and therefore increased the fructose level, thus modifying the short-chain carbohydrate composition. Based on our knowledge, this research is among the first ones investigating the fibre and short-chain composition of rye from the seeds to the consumable final products.