bluuebunny/crossref_metadata_2025 huggingface dataset:
Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis
Authors: Anajirih Nuha , Abdeen Ahmed , Taher Ehab S. , Abdelkader Afaf , Abd-Ellatieff Hoda A. , Gewaily Mahmoud S. , Ahmed Nashwa E. , Al-Serwi Rasha H. , Sorour Safwa M. , Abdelkareem Heba M. , Ebrahim Elturabi , El-Sherbiny Mohamed , Imbrea Florin , Imbrea Ilinca , Ramadan Mahmoud M. , Habotta Ola A.
Published: August 2024

Introduction: Isoproterenol (ISO) is regarded as an adrenergic non-selective β agonist. It regulates myocardial contractility and may cause damage to cardiac tissues. Alchemilla vulgaris (AV) is an herbal plant that has garnered considerable attention due to its anti-inflammatory and antioxidant bioactive components. The present investigation assessed the cardioprotective potential of AV towards ISO-induced myocardial damage.

Methods: Four groups of mice were utilized: control that received saline, an ISO group (85 mg/kg, S.C.), ISO + AV100, and ISO + AV200 groups (mice received 100 or 200 mg/kg AV orally along with ISO).

Results and discussion: ISO induced notable cardiac damage demonstrated by clear histopathological disruption and alterations in biochemical parameters. Intriguingly, AV treatment mitigates ISO provoked oxidative stress elucidated by a substantial enhancement in superoxide dismutase (SOD) and catalase (CAT) activities and reduced glutathione (GSH) content, as well as a considerable reduction in malondialdehyde (MDA) concentrations. In addition, notable downregulation of inflammatory biomarkers (IL-1β, TNF-α, and RAGE) and the NF-κB/p65 pathway was observed in ISO-exposed animals following AV treatment. Furthermore, the pro-apoptotic marker Bax was downregulated together with autophagy markers Beclin1 and LC3 with in ISO-exposed animals when treated with AV. Pre-treatment with AV significantly alleviated ISO-induced cardiac damage in a dose related manner, possibly due to their antioxidant and anti-inflammatory properties. Interestingly, when AV was given at higher doses, a remarkable restoration of ISO-induced cardiac injury was revealed.
The application of rhubarb concoctions in traditional Chinese medicine and its compounds, processing methods, pharmacology, toxicology and clinical research
Authors: Wen Yi , Yan Pei-Jia , Fan Pei-Xuan , Lu Shan-Shan , Li Mao-Ya , Fu Xian-Yun , Wei Shao-Bin
Published: August 2024

Objective

This study reviews the development of rhubarb processing and the current status of pharmacological research. We summarized the effects of different processing methods on the active compounds, pharmacological effects, and toxicity of rhubarb, as well as the clinical application of different concoctions, providing reference for further pharmacological research and clinical application of rhubarb.

Methods

A comprehensive literature review was conducted using databases such as Pubmed, Embase, National Science and Technology Library, Web of science, CNKI, China Science and Technology Journal Database, SinoMed, and the Pharmacopoeia of the People’s Republic of China. Search terms included “rhubarb”, “raw rhubarb”, “wine rhubarb”, “cooked rhubarb”, “rhubarb charcoal”, “herbal processing”, “compounds”, “pharmacological effects”, “inflammation”, “gastrointestinal bleeding”, and “tumor”.

Results

Historical records of rhubarb processing date back to the Han Dynasty, with continual innovations. Currently, the types of rhubarb used in traditional Chinese medicine have stabilized to three species: Rheum palmatum L., Rheum tanguticum Maxim.ex Balf. and Rheum officinale Baill. Common concoctions include raw rhubarb, wine rhubarb, cooked rhubarb and rhubarb charcoal. The active compounds of rhubarb are known to defecation, exhibit antibacterial and anti-inflammatory properties, regulate coagulation, protect the digestive system, and possess anti-tumor activities. Guided by Chinese medicine theory, the use of different rhubarb concoctions can enhance specific effects such as purgation to eliminate accumulation, clearing heat and toxins, cooling blood to stop hemorrhages, activating blood circulation to remove blood stasis, and inducing dampness to descend jaundice, thereby effectively treating various diseases. The therapeutic impact of these concoctions on diseases reflects not only in the changes to the active compounds of rhubarb but also in the formulations of traditional Chinese medicine. Processing has also shown advantages in reducing toxicity.

Conclusion

Different processing methods alter the active compounds of rhubarb, thereby enhancing its various pharmacological effects and meeting the therapeutic needs of diverse diseases. Selecting an appropriate processing method based on the patient’s specific conditions can maximize its pharmacological properties and improve clinical outcomes.
Shallow tillage mitigates plant competition by increasing diversity and altering plant community assembly process
Authors: Li Zihao , Qiao Jirong , Li Zhuofan , Gao Xiaowei , Hong Guangyu , Yang Haifeng , Hu Ercha , Liu Chenming , Wang Xiaojiang , Liu Guanzhi , Gao Runhong
Published: August 2024

Introduction

Understanding how human activities affect biodiversity is needed to inform systemic policies and targets for achieving sustainable development goals. Shallow tillage to remove Artemisia ordosica is commonly conducted in the Mu Us Desert. However, the impacts of shallow tillage on plant community species diversity, phylogenetic structure, and community assembly processes remain poorly understood.

Methods

This study explores the effects of shallow tillage on species diversity including three a-diversity and two b-diversity indicators, as well as phylogenetic structure [phylogenetic diversity (PD), net relatedness index (NRI), and nearest taxon index (NTI)]. Additionally, this research analyzes the effects of shallow tillage on the community assembly process.

Results and discussion

The results showed that the a-diversity index, b-diversity index, and PD of the shallow tillage (ST) communities were significantly higher than those of the non-shallow tillage (NT) communities, and the phylogenetic structures of both the ST and NT communities tended to be differentiated, with competitive exclusion being the main mechanism of plant assembly. However, shallow tillage increased the relative importance of the stochastic processes dominated by dispersal limitation, mitigating plant competition in the communities. This conclusion was supported by the Raup–Crick difference index-based analysis.

Conclusion

Therefore, for the ecological restoration of the Mu Us Desert, species with adaptability and low niche overlap should be selected to increase the utilization efficiency of the environmental resources. The results of this study provide a foundation for policy development for ecosystem management and restoration in the Mu Us Desert.
Who stays? Who goes? Motivation and tendency to drop out in music schools
Authors: Wieser Martin , Novak-Geiger Verena , Müller Florian H.
Published: August 2024

Based on self-determination theory, this study examined the extent to which the satisfaction of the basic psychological needs for autonomy, competence, and social relatedness in instrumental lessons explain the quality and quantity of motivation, which are responsible for persistence and dropout in music schools. This study also investigated whether parental involvement contributes to dropout. A total of 140 music students from Austria (37.16% male, 62.1% female, 0.8% diverse) were surveyed using a quantitative questionnaire. The central variables are the tendency to dropout (dependent variable) and, as predictors, the motivational regulation styles, the satisfaction of basic psychological needs in the classroom and parental involvement. The results of a structural equation model indicated that satisfaction of basic needs in class and parental involvement, mediated by motivation, predicted dropout tendencies. Autonomous motivation in lessons is negatively associated and controlled motivation is positively associated with the tendency to drop out of music schools. Satisfaction of basic psychological needs during lessons and parental involvement predicts autonomous motivation. However, basic psychological needs cannot predict controlled motivation but parental involvement can predict controlled motivation to a limited extent. Finally, this study emphasizes the practical importance of need satisfaction and parental involvement in motivation and continuing to play a musical instrument.
The work stress, occupational burnout, coping strategies and organizational support of elite sports coaches in Sichuan Province: the mediating role of organizational support
Authors: Yu Liang , Cheng Liang
Published: August 2024

Objective

This study investigated the relationships between job pressure, occupational burnout, organizational support and coping strategies among competitive sports coaches in Sichuan Province, China. It also assesses the impact of job pressure on occupational burnout and the mediating roles of organizational support and coping strategies.

Methods

A survey was conducted with 207 competitive sports coaches from Sichuan Province, China. Basic information and data on job pressure, occupational burnout, organizational support and coping strategies were collected. Correlations between variables were analyzed, and a theoretical model for hypothesizing the mediating effects was established. A multiple regression model was used to predict the relationships between occupational burnout and job pressure, organizational support and coping strategies.

Results

(1) Job pressure was significantly positively correlated with occupational burnout (R = 0.436, p < 0.001) and negative coping (R = 0.389, p < 0.001) but significantly negatively correlated with organizational support (R = −0.503, p < 0.001). Occupational burnout was significantly negatively correlated with academic title (R = −0.158, p = 0.023) and organizational support (R = −0.349, p < 0.001) but significantly positively correlated with negative coping (R = 0.440, p < 0.001). Organisational support was significantly positively correlated with positive coping (R = 0.222, p = 0.001) but significantly negatively correlated with negative coping (R = −0.207, p = 0.003). (2) Mediating effects: Job pressure indirectly affects occupational burnout via organizational support and negative coping strategies. (3) Multiple regression: Y1 (Job Pressure) = 69.262 + 1.172 × Emotional Exhaustion −2.231 × Emotional Support +1.041 × Negative Coping −6.554 × Academic Title (from high to low). Y2 (Occupational Burnout) = 25.609 + 0.141 × Job Pressure − 0.306 × Organisational Support +0.620 × Negative Coping −2.097 × Academic Title.

Conclusion

Job pressure is a significant factor leading to occupational burnout among competitive sports coaches in Sichuan Province, China, and factors such as role, interpersonal relationships and career development are closely related to occupational burnout. The sense of organizational support and negative coping strategies play a mediating role between job pressure and occupational burnout. Reducing emotional exhaustion and negative coping, enhancing emotional support and improving the academic titles of coaches can help to reduce job pressure and occupational burnout among competitive sports coaches in Sichuan Province.
Religion and mental health: an Eastern Mediterranean region perspective
Authors: Ghuloum Suhaila , Al-Thani Haya A. Q. F. , Al-Amin Hassen
Published: August 2024

In the last decade, spirituality gained increasing recognition, with an individualized approach to the significance of symptoms and the purpose of treatment. Many psychiatrists started adopting the term “biopsychosocial-spiritual” management. Modern psychological therapies have drawn from the principles of ancient Eastern traditions. However, the spiritual beliefs within Islam and their impact on mental well-being have yet to be studied sufficiently. The Eastern Mediterranean region is largely Muslim and shares similar cultural beliefs. This paper explores some of these beliefs and their impact on perceptions of mental health and help-seeking behavior. The paper will focus primarily on the religious ideologies, the concepts of punishment and reward from Allah (God) in the context of the high stigma associated with mental illness in the region, and the knowledge, attitudes, and perceptions toward people with mental illness. We will explore cultural beliefs in possession, evil eye, and black magic and how they influence treatment adherence. Traditional and faith healers remain very popular in this part of the world and are often the first line of treatment for people presenting with mental illness. Suicide and self-harming are particularly sensitive areas due to their religious implications in life and death, as well as the afterlife. Despite the global interest in the Eastern Mediterranean region, there still is a shortage of research on the intercultural aspects of this region, especially regarding mental health assessments. In this regard, we will explore some published literature from Qatar and draw comparisons with regional findings.
A suicide attentional bias as implicit cognitive marker of suicide vulnerability in a high-risk sample
Authors: Brüdern Juliane , Spangenberg Lena , Stein Maria , Gold Helena , Forkmann Thomas , Stengler Katarina , Glaesmer Heide
Published: August 2024

Introduction

Suicide risk assessment based on self-report questionnaires is considered as problematic because risk states are dynamic and at-risk individuals may conceal suicidal intentions for several reasons. Therefore, recent research efforts increasingly focus on implicit risk markers such as the suicide attentional bias (SAB) measured with the Suicide Stroop Task (SST). However, most SST studies failed to demonstrate a SAB in individuals with suicide risk and repeatedly demonstrated insufficient psychometrics of the SST. This study aimed to investigate a SAB using a modified SST (M-SST) and to test its psychometric properties.

Method

We compared n = 61 healthy controls and a high-risk inpatient sample of n = 40 suicide ideators and n = 40 suicide attempters regarding interference scores of positive, negative and suicide-related words. Interference scores were calculated by subtracting the mean reaction time (mean RT) of the neutral words from the mean RT of the suicide-related words (mean RT Suicide –mean RT Neutral), resulting in a suicide-specific interference score. Similarly, interference scores were calculated for the positive and negative words by subtracting the mean RT of neutral words from the mean RT of positive and negative words.

Results

A Group × Interference ANOVA showed a significant interaction effect (p <.001, ηp2 = .09), indicating that group effects significantly vary across interference type. Post hoc comparisons revealed that both ideators and attempters demonstrated greater interferences only for suicide-related words compared to healthy controls, indicating a SAB in patients, while a difference between ideators and attempters was lacking. The suicide interference score classified with an AUC = 0.73, 95% CI [0.65 – 0.82], p <.001, between controls and patients with STBs. The M-SST demonstrated good internal consistency and convergent validity.

Discussion

The study adds evidence to the assumptions of the Cognitive Model of Suicide, viewing a SAB as a cognitive marker of suicide vulnerability independently of the engagement in suicidal behavior. The results’ clinical implications are discussed in the context of recommended intervention strategies during an acute suicidal state. Future studies with the M-SST should include non-suicidal patient controls to investigate whether a SAB is uniquely related to suicidality.
Targeting maternal gut microbiome to improve mental health outcomes—a pilot feasibility trial
Authors: Gallant Faith , Cooley Kieran , Grigoriadis Sophie , Ebrahimi Neda
Published: August 2024

Background

Perinatal depression and anxiety (PDA) is prevalent in new and expectant mothers, affecting millions of women worldwide. Those with a history of mood and anxiety disorders are at the greatest risk of experiencing PDA in a subsequent pregnancy. Current safety concerns with pharmacological treatments have led to a greater need for adjunctive treatment options for PDA. Changes in the composition of the microbiome have been associated with various diseases during pregnancy, and these changes are thought to play some role in perinatal mood disorders. While the relationship between PDA and the microbiome has not been explored, evidence suggests that nutritional interventions with fiber, fish oils, and probiotics may play a favorable role in neuropsychiatric outcomes during and after pregnancy. The primary objective of the present study is to assess the feasibility and acceptability of a combination of nonpharmacological interventions to maintain stability in pregnant women who have a history of depression and/or anxiety. This study will also aim to understand ease of recruitment and protocol adherence in this cohort.

Methods

This is a single-centered, partially randomized, placebo-controlled, double-blind feasibility trial. One hundred pregnant women with a history of depression and/or anxiety/PDA will be recruited and randomized into one of four arms, which could include the following: receiving a daily dose of both investigational products and dietary counseling on increasing dietary fiber, receiving a daily dose of both investigational drugs only, receiving fish oil investigational product and placebo, and a control arm with no intervention. The study involves six study visits, all of which can be conducted virtually every 3 months from the time of enrollment. At all study visits, information on diet, mental health, physical activity, and sleep quality will be collected. Additionally, all participants will provide a stool sample at each visit.

Discussion

It is anticipated that pregnant women with a history of depression and anxiety will be particularly interested in partaking in this trial, resulting in favorable recruitment rates. Given the positive findings of omega-3 fatty acids (O3FAs) and probiotic supplements on mental health symptoms in nonpregnant adults, we expect a similar trend in PDA symptoms, with a low likelihood of adverse events. This study will build the foundation for larger powered studies to further contribute evidence for the efficacy of this potential preventative treatment option.

Trial registration

This trial was registered at ClinicalTrials/gov on October 6, 2023; NCT06074250. Trial Sponsor: The Canadian College of Naturopathic Medicine, 1255 Sheppard Ave E, Toronto, ON M2K 1E2, 416-498-1255.
Monitoring, evaluation, and learning: the key to building effective partnerships with government to improve maternal and child health in the Rakai and Kyotera Districts of Uganda
Authors: Sklar Marc , Murokora Daniel
Published: August 2024

This article emphasizes the significance of the Monitoring, Evaluation, and Learning (MEL) system within Babies and Mothers Alive (BAMA) Foundation in building effective sustainable interventions at scale. The foundation aims to enhance the availability of high-quality reproductive, maternal, and newborn care services within the government health sector. The distinguishing characteristic of the MEL system is its integration of organizational learning as a strategic approach to inform the development of dynamic program designs. To do this, it has been necessary to identify crucial requirements through open data exchange with all pertinent stakeholders. This paper demonstrates that our approach to evidence-based learning in a diverse population of locally-based actors and stakeholders, gives voice to the community-based health practitioners and patients that is necessary for transformative maternal health delivery systems. The act of sharing data has presented several possibilities for enhancing current initiatives and extending the reach and scale of our partnership model. We trace the development of the core components of learning and decision making, and reflect on the transition of the program to scale using the LADDERS paradigm. The application of our model of practice has been associated with the increased financially viability and the potential for the sustainable scaling of the program intervention.
The influence of COVID-19 pandemic on body mass and cardiopulmonary endurance of Chinese adolescents: a longitudinal follow-up study
Authors: Cheng Hao , Jiao Long , Liu Bin
Published: August 2024

Background

With the spread and spread of COVID-19 around the world, youth’s learning, lifestyle and health have been greatly affected. Based on the current research, there is no adequate analysis of the development of young people’s physique and heart and lung health during COVID-19, and there is a lack of relevant targeted research. The aim of this study was to investigate the changes of BMI and Maximum Oxygen Absorption (VO2max) in 12–14 year old teenagers before and after COVID-19.

Method

The BMI, 1,000/800 m running time and associated data related to 29,813 individuals between 2019 and 2022 were collected by cluster sampling, and the changes of BMI Z and VO2max before and after the outbreak were analyzed. Moreover, the relationship between BMI and cardiovascular endurance was analyzed by means of multi-linear stepwise regression.

Results

The covariance analysis models indicated that compared with 2019, adolescent weight, BMI, and 1,000/800 m running time showed varying degrees of growth in 2020, while lung capacity decreased. All indicators achieved rapid rebound in 2021 and 2022 (p < 0.01); the one-way analysis of variance models indicated that The BMI Z score and VO2max of adolescents showed growth and decline in 2020, respectively, and achieved rapid recovery and development in 2021 and 2022 (p < 0.01). The results of the multiple linear stepwise regression analysis indicate that, after the years of BMI Z and novel coronavirus infection were included (△R2 = 0.179), adolescents’ overweight and obesity were positively correlated with the maximum oxygen uptake (B = 0.643, 95%CI = 0.634 ~ 0.652); There is a negative correlation between weight loss and maximum oxygen uptake (B = −0.510, 95%CI = −0.537~−0.484); The year of novel coronavirus infection was positively correlated with the maximum oxygen uptake of adolescents (B = 0.116, 95%CI = 0.107~0.125).

Conclusion

This study shows that the impact of COVID-19 on BMI and heart and lung health in adolescents is significant. Young people of all ages and sexes showed similar developmental trends.
Ergonomics in the operating room and surgical training: a survey on the Italian scenario
Authors: Restaino Stefano , D’Indinosante Marco , Perelli Federica , Arcieri Martina , Cherchi Vittorio , Petrillo Marco , Cavaliere Anna Franca , Cianci Stefano , Pellecchia Giulia , Meniconi Roberto Luca , Coppola Alessandro , Chiantera Vito , Scambia Giovanni , Driul Lorenza , Vizzielli Giuseppe ,   SPIGC Working Group
Published: August 2024

Introduction

Surgical-related injuries are frequent, in fact the reported percentage of musculoskeletal disorders in surgeons is between 47% and 87%. These conditions are caused by long periods of standing, incorrect postures, repeated movements, little rest between operations, the lack of integrated operator rooms, the correct number and arrangement of monitors and the use of non-ergonomic instruments. This survey aims to assess the Italian overview both highlighting how prevalent surgical-related injury is in our surgeons and whether there is an operating room ergonomics education program in Italian surgical specialty schools.

Methods

An anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of 3 different sections concerning the general characteristics of the participants, their surgical background and any training performed, and any injuries or ailments related to the surgical activity. The survey was carried out in the period 1th of December 2022 and the 6th of February 2023.

Results

At the close of our survey, 300 responses were collected. Among the participants, the two most represented specialties were Gynecology and Obstetrics (42.3%) and General Surgery (39.7%) and surgeons were mainly employed in the Northern regions of Italy (54.8%). Analyzing the participants’ background, 61.7% of the respondents had laparoscopic training during their training and only 53.1% had a pelvic trainer during their residency. In accordance with 98.7% of the respondents, during surgery we have the feeling of being in an uncomfortable position that causes discomfort or muscle pain, and regarding the frequency of these discomforts, the majority of our study population experiences these problems monthly (46.2%), while in 29.6% it is experienced weekly, 12.1% annually and finally 12.1% daily. The surgical approach that is most correlated with these disorders is laparoscopy (62.7%) while the one that causes the least discomfort is robotic surgery (1.4%). These discomforts cause 43.9% of our population to take a break or do short exercises to reduce pain during surgery, and the body areas most affected are the back (61.6%), neck (40.6%) and shoulders (37.8%).

Conclusion

Despite this, our survey allows us to highlight some now-known gaps present in the surgical training program of our schools and the lack of protection toward our surgeons during their long career.
Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review
Authors: De Hondt Lena , Cosemans Charlotte , Plusquin Michelle , Mangelings Debby , Van Eeckhaut Ann , Tommelein Eline
Published: August 2024

Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that has long been considered a concern only in the pediatric population. However, symptoms often sustain into adulthood and may require medication. For women with ADHD, this also means dealing with the disorder during the reproductive period. Medication safety during pregnancy and breastfeeding is a critical concern, and the potential transfer of ADHD medication to infants remains a topic of scientific interest. The quantification of ADHD medications in both maternal blood and breast milk are vital for understanding their pharmacokinetics and potential exposure risks for (nursing) infants. This review aims (1) to compile and critically assess existing research on the transfer of ADHD medications into breast milk and the potential implications for nursing infants and (2) to provide a comprehensive overview and discussion of the literature regarding the quantification of methylphenidate, amphetamine, atomoxetine, viloxazine, guanfacine, clonidine and bupropion in the blood, urine, oral fluid, and breast milk with liquid chromatography. A literature search was conducted using PubMed, Scopus, and Web of Science, to identify relevant articles published from January 2014 up to December 2023. We illustrate the lack of methods to simultaneously monitor multiple ADHD medications as well as the lack of developed methods for breast milk. Finally, we highlight the need for continued research to refine our understanding of medication transfer into breast milk and potential risks, and to develop clinical guidelines to support mothers with ADHD in making informed choices regarding medication use during pregnancy and lactation.
Person-centered aural rehabilitation program improved mood, cognition, and auditory processing in a professional musician who uses a hearing aid and cochlear implant: Case Report
Authors: Brennan Christine , Spence-Olson McKenna , Cormier Kayla , Tennant Sherri , Sharma Anu
Published: August 2024

Introduction

Aural rehabilitation focused on music for individuals with cochlear implants (CIs) and/or hearing aids (HAs) typically emphasizes perceptual skills rather than enjoyment of music. Yet, those with CIs and/or HAs often struggle to enjoy music, complaining that it sounds distorted with the implant or HAs. Typically, aural rehabilitation programs require a significant time commitment, but this may not be feasible or preferable for many patients. This study aimed to evaluate the efficacy of two individualized intensive 3-week home practice programs focused on enjoyment of music, a personal goal for this subject.

Methods

The subject was a professional musician who used a CI and HA. Cognitive measures of global cognitive function, executive function, processing speed, auditory working memory, visual-spatial abilities, verbal fluency, and auditory-verbal memory, as well as auditory electrophysiology (EEG) measures were conducted pre-post experiment 2. Two experiments were undertaken to evaluate responses to two practice programs that incorporated different variations in listening dosage and intervention activities.

Results

Experiment 1 resulted in minimal measurable improvements related to music likability ratings, with the highest dosage condition showing a small increase in average likability rating from baseline to week 3. The results of experiment 2 revealed an improvement in likability ratings only when dosage steadily increased each week. The subject also reported improved mood and decreased frustration during weeks two and three of experiment 2. Finally, we found improvement pre-post experiment 2 on several cognitive and EEG measures.

Discussion

The results of these experiments are encouraging and support the use of an individualized, person-centered, and semi-structured home practice program to increase music enjoyment and improve quality of life and auditory processing for individuals with hearing loss. Future studies should aim to increase sample size and explore pairing person-centered home practice programs with concurrent clinician-lead aural rehabilitation.
Unexpected judgments: the role of gender identity and provocation on blame and affect in a mock jury paradigm
Authors: Totton Rebecca R. , McKeon Kayla
Published: August 2024

Introduction

Panic defenses are a form of legal defense positing that a defendant is less culpable for their crime because of an extreme emotional reaction. However, limited research has examined the use of panic defenses when the victim is a transgender individual.

Methods

In two studies (Total N = 995) previously existing scales and vignettes were used to evaluate perceptions of panic defenses when the victim was a transgender woman, transgender man, or a gay man. Study 1 (N = 557) used a 2 (sexual provocation or non-sexual provocation) x 3 (transgender woman, transgender man, or gay man victim) design to evaluate perceptions of victim blame, negative affect, and perception that the crime was a hate crime.

Results

Contrary to demographic data trends, Study 1 found that transgender women were rated more positively as victims, were blamed less than transgender men or gay men, and that the crime was more likely to be labeled as a hate crime. Study 2 (N = 438) was a replication of Study 1. While the results were largely non-significant, the trend in means was in the same direction as the findings of Study 1.

Discussion

We argue that these findings, despite not being in line with broader data on the topic, are important evidence that anti-transgender research, particularly in mock jury settings, may need to reimagine existing designs and vignettes to understand rates of violence and discrimination toward transgender communities.
Reviving life that has ceased on October the 7th: an attachment perspective on a virtual reality intervention
Authors: Bodner Ehud , Mikulincer Mario , McMahon Elizabeth , Rizzo Albert
Published: August 2024

Unfortunately, in recent years, wars have forced many civilians to evacuate their homes and move to safe zones. The event of October the seventh that took place in many Kibbutzim near the Gaza strip, exposed families who were on a Jewish holiday, to the murder of family and community members. They had to leave their burned houses and move to hotels and apartment buildings in other parts of Israel. Many people, also from the Northen parts of the country, are still in new safe zones, and have huge difficulties in returning to their houses (and not only because of objective security reasons). In this “perspective” article we propose a Virtual Reality (VR) application, which is based on past and current research in the fields of attachment theory and traumatic grief. We propose that in addition to the use of exposure therapy, a VR simulation which will activate the attachment system, can reorganize the evacuees’ figure and place attachment representations. We suggest that such a simulation will revive the evacuees’ sense of safe-haven and secure base and enable them to return to their home place, or to adjust to a new place, thereby leading to optimal adjustment. We start with a presentation of the theory of attachment, place attachment, attachment and loss and the two-track model of bereavement. Then, we describe the design of our VR intervention that aims to address this challenge from the attachment theory perspective with the evacuees. Finally, we discuss the challenges that need to be dealt with to implement the VR interventions through resilience centers in Israel.
Using index and physically-based models to evaluate the intrinsic groundwater vulnerability to non-point source pollutants in an agricultural area in Sardinia (Italy)
Authors: Porru Maria Chiara , Hassan Shawkat B. M. , Abdelmaqsoud Mostafa S. M. , Vacca Andrea , Da Pelo Stefania , Coppola Antonio
Published: August 2024

This research aims at studying the intrinsic vulnerability of groundwater to diffuse environmental pollutants in the Muravera coastal agricultural area of Sardinia, Italy. The area faces contamination risks arising from agricultural practices, especially the use of fertilizers, pesticides, and various chemicals that can seep into the groundwater. The study examined the interplay among hydrological elements, including soil characteristics, groundwater depth, climate conditions, land use, and aquifer properties. To do that, the outcomes of FLOWS 1D physically-based agrohydrological model were analyzed in parallel with those of the overlay-and-index model SINTACS, in a sort of reciprocal benchmarking. By using FLOWS, water movement and solute transport in the unsaturated zone were simulated by, respectively, solving the Richard Equation (RE) and the Advection-Dispersion equation (ADE). As such, this model allowed to account for the role of soil hydraulic and hydro-dispersive properties variability in determining the travel times of a conservative solute through the soil profile to the groundwater. For FLOWS simulations, a complete dataset was used as input, including soil horizons, soil physical and hydraulic properties of 36 soil profiles, average annual depth to groundwater table at each soil profile (ranging from 1 to 50 meters), and climatic temporal series data on rainfall and evapotranspiration. Detailed analyses of travel times for the movement of 25, 50, 75, and 100% of the solute mass to reach groundwater were conducted, revealing that the depth to groundwater predominantly influences vulnerability. This result was coherent with SINTACS vulnerability map due to the large impact of the depth to groundwater on SINTACS analysis.
Sustainable varicose vein therapy using functionalized hydrogels derived solely from livestock waste
Authors: Corridon Peter R. , Ali Zehara M. , Shibru Meklit G. , Paunovic Jovana , Pantic Igor V. , Preston Shaun H.
Published: August 2024

Developing sustainable and effective treatments for chronic venous insufficiency (CVI) is crucial. In this study, we propose an innovative restorative approach utilizing hydrogels derived from the decellularized extracellular matrix (dECM) of cadaveric vascular tissues, adipose-derived stem cells (ADSCs), and gold nanoparticles (AuNPs). This therapeutic method leverages waste valorization by repurposing discarded cadaveric tissues from slaughterhouse livestock. The dECM hydrogels, enriched with ADSCs and AuNPs, offer a biocompatible scaffold that supports cellular differentiation and vascular integrity. Our approach addresses the limitations of current allo-, auto-, and xenograft methods by enhancing integration and functionality while potentially reducing costs through sustainable practices. This study explores functionalized hydrogel formulation solely generated from agri-food waste, gelation mechanisms, and preliminary cost-effectiveness, presenting a promising new avenue for treating early-stage varicose veins that can ultimately be translated to human models using discarded tissues.
Evolution of Esophageal Cancer Incidence Patterns in Hong Kong, 1992-2021: An Age-Period-Cohort and Decomposition Analysis
Authors: Wang Lijun , Du Jianqiang , Sun Haifeng
Published: August 2024

Objective

To elucidate the historical trends, underlying causes and future projections of esophageal cancer incidence in Hong Kong.

Methods

Utilizing the Age-Period-Cohort (APC) model, we analyzed data from the Hong Kong Cancer Registry (1992–2021) and United Nations World Population Prospects 2022 Revision. Age-standardized incidence rates were computed, and APC models evaluated age, period, and cohort effects. Bayesian APC modeling, coupled with decomposition analysis, projected future trends and identified factors influencing incidence.

Results

Between 1992 and 2021, both crude and age-standardized incidence rates of esophageal cancer witnessed significant declines. Net drifts exhibited pronounced downward trends for both sexes, with local drift diminishing across all age groups. Period and cohort rate ratios displayed a consistent monotonic decline for both sexes. Projections indicate a continued decline in esophageal cancer incidence. Population decomposition analysis revealed that epidemiological changes offset the increase in esophageal cancer cases due to population growth and aging.

Conclusion

The declining trend of esophageal cancer in Hong Kong is influenced by a combination of age, period, and cohort. Sustaining and enhancing these positive trends requires continuous efforts in public health interventions.
Impact of Blood Pressure on Allograft Function and Survival in Kidney Transplant Recipients
Authors: Kim Hyo Jeong , Kim Kyung Won , Joo Young Su , Ryu Junghwa , Jung Hee-Yeon , Jeong Kyung Hwan , Kim Myung-Gyu , Ju Man Ki , Han Seungyeup , Lee Jong Soo , Kang Kyung Pyo , Ro Han , Lee Kyo Won , Huh Kyu Ha , Kim Myoung Soo , Kim Beom Seok , Yang Jaeseok
Published: August 2024

The optimal target blood pressure for kidney transplant (KT) patients remains unclear. We included 808 KT patients from the KNOW-KT as a discovery set, and 1,294 KT patients from the KOTRY as a validation set. The main exposures were baseline systolic blood pressure (SBP) at 1 year after KT and time-varying SBP. Patients were classified into five groups: SBP <110; 110–119; 120–129; 130–139; and ≥140 mmHg. SBP trajectories were classified into decreasing, stable, and increasing groups. Primary outcome was composite kidney outcome of ≥50% decrease in eGFR or death-censored graft loss. Compared with the 110–119 mmHg group, both the lowest (adjusted hazard ratio [aHR], 2.43) and the highest SBP (aHR, 2.25) were associated with a higher risk of composite kidney outcome. In time-varying model, also the lowest (aHR, 3.02) and the highest SBP (aHR, 3.60) were associated with a higher risk. In the trajectory model, an increasing SBP trajectory was associated with a higher risk than a stable SBP trajectory (aHR, 2.26). This associations were consistent in the validation set. In conclusion, SBP ≥140 mmHg and an increasing SBP trajectory were associated with a higher risk of allograft dysfunction and failure in KT patients.
Genome-Wide Identification of Caffeic Acid O-Methyltransferase Gene Family in Medicago truncatula: MtCOMT13-Mediated Salt and Drought Tolerance Enhancement
Authors: Cui Kailun , Lv Yanzhen , Zhang Zhao , Sun Qingying , Yao Xingjie , Yan Huifang
Published: August 2024

Legumes are important grains and forages, providing high-quality proteins, vitamins, and micronutrients to humans and animals. Medicago truncatula is a close relative of alfalfa (Medicago sativa). Caffeic acid O-methyltransferase (COMT), a key gene that is identified to be essential for melatonin synthesis, plays a significant role in plant growth, development, and abiotic stress responses. However, a systematic study on the COMT gene family in M. truncatula has still not been reported. In this study, 63 MtCOMT genes were identified and categorized into three groups. Gene structure and conserved motif analyses revealed the relative conservation of closely clustered MtCOMTs within each group. Duplicated events in MtCOMT members were identified, and segmental duplication was the main mean. Cis-acting element prediction revealed the involvement of MtCOMTs in growth and development and response to light, stress, and plant hormones. RNA-seq data analysis showed that 57 MtCOMTs varied under salt and drought stresses. The RT-qPCR expression patterns showed that MtCOMT9, MtCOMT13, MtCOMT22, MtCOMT24, MtCOMT43, and MtCOMT46 were related to salt and drought responses in M. truncatula. Additionally, Arabidopsis thaliana overexpressing MtCOMT13 displayed superior plant growth phenotypes and enhanced tolerance to salt and drought stresses through higher photosynthetic parameters and activities of antioxidant enzymes, which indicated that MtCOMT13 played an important role in positively regulating plant salt and drought tolerance. These findings contribute to an improved understanding of MtCOMTs’ roles in abiotic stress responses in M. truncatula, providing an important theoretical basis and genetic resource for legume species resistance breeding in the future.
The Activation of Magnesium Sintering by Zinc Addition
Authors: Teslia Serhii , Kovalenko Mykyta , Teslia Mariia , Vterkovskiy Mykhailo , Solodkyi Ievgen , Loboda Petro , Soloviova Tetiana
Published: August 2024

Light alloys based on magnesium are widely used in most areas of science and technology. However, magnesium powder alloys are quite difficult to sinter due to the stable film of oxides that counteracts diffusion. Therefore, finding a method to activate magnesium sintering is urgent. This study examines the effect of adding 5 wt. % and 10 wt. % zinc to the sintering pattern of magnesium powders at 430 °C; a dwell of 30 min was used to homogenize at the densification’s temperature. Scanning electron microscopy (SEM) was used to characterize the alloy’s microstructure, while the phase composition was characterized using X-ray diffraction (XRD) and energy dispersion spectroscopy (EDS). The sintering densities of Mg–5Zn and Mg–10Zn were found to be 88% and 92%, respectively. The results show that after sintering, a heterophase structure of the alloy is formed based on a solid solution and phases MgZn and Mg50Zn21. To establish the sintering mechanism, the interaction at the MgO and Zn melt phase interface was analyzed using the sessile drop method. The minimum contact angle—65°—was discovered at 500 °C with a 20 min holding time. It was demonstrated that the sintering process in the Mg–Zn system proceeds through the following stages: (1) penetration of zinc into oxide-free surfaces; (2) crystallization of a solid solution, intermetallics; and (3) the removal of magnesium oxide from the particle surface, with oxide particles deposited on the surface of the sample.
Effects of Early Lactation Milking Frequency in an Automated Milking System on Cow Performance
Authors: Kammann Erin M. , French Elizabeth A. , Jozik Natalie S. , Li Wenli , Pralle Ryan S.
Published: August 2024

Automated milking systems (AMS) are increasingly adopted for dairy cow production, promoting individualized cow management dependent on factors like lactation stage, age, and productivity. The study objective was to investigate the effects of early lactation milking frequency on cows milked via AMS. Multiparous Holstein cows blocked by parity and due date were randomly assigned to treatments (n = 8 per treatment): three (3X) or six (6X) milkings per day (MPD). The experimental phase (EXP) was defined as 4 to 29 days in milk (DIM). The AMS settings were programed so 3X cows were limited to three MPD while 6X cows were allowed six MPD. Afterwards was the carry over phase (CO) ranging from 30 to 90 DIM; all cows were allowed up to six MPD. Measurements by the AMS included bodyweight, milk yield (MY), and pellet intake. Weekly composite milk samples were analyzed for macronutrient composition and fatty acid (FA) profile. Coccygeal blood was sampled at 3, 8 ± 1, and 13 ± 1 DIM; concentrations of blood plasma analytes were quantified. Greater MPD was achieved for 6X cows versus 3X cows during EXP, but similar during the CO. Daily MY was non-separable during the EXP while 6X cows in their third or greater lactation group (3 + LG) had greater MY than 3X cows of the same LG during the CO. Milk fat content and 4% fat-corrected MY were both greater for 6X, 3 + LG cows during the EXP compared to 3X, 3 + LG cows. Milk FA methyl esters (FAME) proportions were different between MPD groups, with 6X, 3 + LG cows having the lowest short, even-chain FA from de novo or post-absorptive origin. Differences in analytes indicated that 6X, 3 + LG cows experienced metabolic stress and incorporated greater FA from adipose tissue. Greater early lactation MPD in AMS may shift cow nutrient partitioning to support greater production in 3+ parity cows.
Phagocytic Function and Flow Cytometric Phenotype of Asian Elephant Monocytes
Authors: Johns Jennifer L. , Baumgartner Trinity R. , Sanchez Carlos R. , Dolan Brian P.
Published: August 2024

Optimal veterinary care of managed elephant populations is vital due to the continued decline of wild populations. Appropriate health monitoring and accurate disease diagnosis include hematologic evaluation. Elephant hematology is distinctive in that elephants have high percentages of monocytes in health. Elephant monocytes also have unusual morphology, a feature shared with manatees and rock hyraxes. Manual white blood cell counting is used for elephant hematology, as analyzers are generally inaccurate. The aims of this study were to evaluate basic cell isolation and functional testing protocols for use in elephant monocyte research, and to test several available antibodies via flow cytometry for use in elephant monocyte identification. Peripheral blood samples from five Asian elephants (Elephas maximus) were used. Methods for monocyte isolation and evaluation of phagocytic function were established. Putative lymphocyte and monocyte populations were identified using a scatter on flow cytometry. Antibodies against CD11b, CD11c, CD14, and ionized calcium-binding adapter molecule 1 (IBA1) were tested, with IBA1 showing the highest apparent diagnostic utility in labeling monocytes. Combined flow cytometric scatter and IBA1 positivity appear to identify Asian elephant monocytes. These data provide a methodologic basis for further investigation into elephant monocyte function and immune response to infection.