bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Operational Level Practical Test Instrument by Using Competency-Based Assessment Model
Authors: Irwan Irwan , Sarifuddin Sarifuddin , Wanda Putra Riki , Devin Hasri
Published: December 2024

The lack relevance of practical ability assessment with industry needs causes nautical technology graduates to not be fully prepared to work in the field. Therefore, it is necessary to develop a practical test instrument that is in accordance with Graduate Learning Outcomes. The purpose of this study is to produce an operational level practical test instrument with a valid, reliable, and effective competency-based assessment model. This type of research is development research by using the Wilson Model and the Oriondo and Antonio Model. Validity test was content validity. Reliability test was test-retest and inter-rater reliability. Effectiveness test used the N-Gain percentage. The results of the study prove that the developed instrument is valid with a validity value 3.8 and criterion A. The instrument is reliable because the t-count value is smaller than the t-table value, meaning that there is no difference between the average values ​​of the three raters. The instrument is effective because the N-Gain percentage = 74.6%. The limitations of this study lie in the limited testing, only focusing on the operational level, and the variation of raters who only come from within the institution. The recommendation from this study is that the developed instrument should be tested in other maritime educational institutions. Then, it is necessary to develop similar instruments for the management level in the maritime sector.
Pengembangan Media Pembelajaran Pop Up Book Pada Materi Simbol dan Bunyi Sila Pancasila
Authors: Alfina Zumra Atika , Rahmi Laili
Published: December 2024

The limited use of teaching media and reliance on Student Worksheets (LKS) as the sole learning tool result in monotonous teaching methods, reducing students' interest, understanding, and creativity. This study aims to identify the development process and practicality of the Pop Up Book learning media. The research method used is Research and Development (R&D) with the ADDIE development model. The data analysis techniques employed include validity and practicality analysis of the Pop Up Book learning media. The research findings indicate that the development process of the learning media comprises several stages: 1) the analysis stage shows that the use of learning media is still minimal and less effective, leading to a lack of student interest, enthusiasm, and understanding of the material. 2) the design stage involves the creation of a Pop Up Book for the symbols and sounds of the Pancasila, including media selection, material collection from various sources, and the use of Pinterest and Canva applications to organize images and initial designs. The book is made using simple materials such as HVS paper, cardboard, and glue, with techniques producing attractive three-dimensional visuals that fit the theme. 3) the development stage aims to determine the validity of the learning media. Validation results by media and material experts indicate it is highly feasible, with average scores of 94% and 92%, respectively. 4) the implementation stage aims to assess the practicality of the learning media. Responses from students and teachers show that the Pop Up Book learning media is highly practical, with an average practicality score of 90.67%. It can be concluded that the Pop Up Book learning media for the symbols and sounds of the Pancasila is proven to be highly feasible (94%) and practical (90.67%) for enhancing students' interest and understanding.
Pengaruh Perbedaan Gender dan Inklusi Keuangan Terhadap Kapabilitas Pemasaran Asuransi Syariah Pada Organisasi NU Padangsidempuan
Authors: Situmeang Saidah Hayati , Imsar Imsar , Syarbaini Ahmad Muhaisin B.
Published: December 2024

This research aims to find out how the influence of gender differences and financial inclusion on sharia insurance marketing capabilities in the NU organization Padangsidempuan. Bannier & Schwarz research, which says that The role of gender differences can have implications for financial literacy and inclusion finance. The type of research used is quantitative research with methods multiple linear regression. The data analysis technique used in this research is purposive sampling technique with hypothesis testing used includes the T test, F test, and coefficient of determination. The sample in this research is the large organization NU in the last 5 years (2018-2022). The results of this research show that gender differences have no effect on insurance marketing capabilities sharia. Meanwhile, the financial inclusion variable has a significant effect on sharia insurance marketing capabilities. Simultaneously variable differences gender and financial inclusion have a significant effect on marketing capability sharia insurance. This research has an Adjusted R Square value of 0.748 or 74.8%. This shows that the dependent variable or marketing capability Sharia insurance can be explained by dependent variables or gender differences and financial inclusion with a score of 74.8. While the remaining 26.2% influenced by other variables. Money was not examined in this study.
Eksistensi Pendidikan Agama Hindu di Era Digital Dalam Memperkuat Karakter Siswa
Authors: Sukerni Ni Made , Arini Ni Wayan
Published: December 2024

The rapid development of technology in the digital era is one of the challenges in developing children's character today. Technology has had an impact in terms of the decline in children's character values. Therefore, Hindu religious education is very important in this situation to help students understand and overcome the moral dilemmas that occur in the digital world. This research aims to determine the efforts that need to be made to strengthen student character in the digital era. This research uses a qualitative type of research using a descriptive analysis approach. The results of this research indicate that cyber technology can be used to create learning strategies that encourage students to learn independently, and the character of education must be consistently included in all Hindu religious learning activities. Apart from school teachers, parents also play an important role in directing children to use technology wisely. The character values ​​that can be instilled in Hindu religious teachings are as follows, religious values, tolerance, discipline, independence, curiosity, friendship/communicativeness, caring for the environment and responsibility.
Tata Susila Dan Pengendalian Diri Menurut Wrhaspati Tattwa
Authors: Suastini Ni Nyoman , Wisarja I Ketut
Published: December 2024

Human life is faced with behavioral problems, where humans must weigh, sort, and decide to choose these actions, and not conflict with the norms or rules that have been agreed upon and determined together by consensus. In the context of living together and socializing, self-control is very important. A person must have the ability to control himself consciously, so as to produce good behavior, not harming others, and in accordance with norms or rules, which is often referred to as “self control”. This article aims to discuss and analyze the teachings of ethics, especially morality and self-control contained in the lontar Wrhaspati Tattwa. The method used in this paper is qualitative, which focuses more on the process and meaning that is studied thoroughly, statically, and concretely in accordance with Hindu ethics and morals. This study is classified as library research which takes the main source through books, libraries, palm texts, and the internet. The results of this study are 1) Sadangga Yoga in Wrhaspati Tattwa consists of Pratyaharayoga, Dhyanayoga, Tarkayoga, Pranayamayoga, Dharanayoga, and Samadhiyoga. 2) In Wrhaspati Tattwa, morality and self-control are characterized by the Triguna nature which is part of the citta, which determines whether human life will experience good or bad. There are two factors that influence self-control and morality, namely age, which is an internal factor, and the environment, which is an external factor, both family and society. Self-control directs behavior to produce positive consequences. In conclusion, Wrhaspati Tattwa teaches that one must control the mind and heart to achieve a harmonious life.
Peran Kepemimpinan Dalam Penguatan Keyakinan (Sradha) Umat Buddha Di Desa Tanjung Kabupaten Jepara
Authors: Darma Widia , Suyatno Tri , Siswoyo Eko
Published: December 2024

Leadership plays a crucial role in achieving shared goals, especially within Buddhist organizations in Tanjung Village, Monastery leaders are not only responsible for resource management but also serve as spiritual role models, motivators, and facilitators for the community. At Monastery, leadership is guided by principles of cooperation, transparency, and openness, encouraging active participation in various religious activities. The influence of social challenges and modern technology has affected the involvement of the younger generation in religious practices. Adaptive leadership is essential to maintain the community’s spiritual vitality and strengthen their faith in Buddhist teachings. By implementing values-based leadership, leaders can foster spiritual harmony, bolster solidarity, and ensure the continuity of Buddhist practices in facing modern challenges. This study employs a descriptive qualitative method to explore the role of leadership in educating Buddhists in Tanjung Village. The findings highlight that monastery leaders play a critical role in goal setting, work planning, and resource management. Leadership practices based on openness, togetherness, and cooperation enable Buddhists to participate voluntarily in decision-making and task division, thereby fostering a sense of responsibility and social solidarity within the community. Additionally, monastery leaders serve as exemplary figures in religious services and facilitators who connect the community with spiritual activities. They contribute to the development of the younger generation through education, arts, culture, and religious programs that enhance Buddhist faith. With their dual roles as administrators and spiritual guides, monastery leaders ensure the preservation of Buddhist teachings and the sustainability of the community, helping Buddhists adapt and societal dynamics.
Analisis Pesan Dakwah Maher Zain dalam Sholawat Burdah di Channel Youtube
Authors: Wati Dini Atika , Arianti Qori Hadijah , Qoimah AI Hidayatul Mus , Zuhriyah Luluk Fikri , Purnomo Ryan
Published: December 2024

This study aims to analyze the signs and messages of da'wah in the Burdah prayer presented on Maher Zain's YouTube channel. The background of this research is the importance of understanding the meaning of signs in modern da'wah media as a means of conveying Islamic values. The formulation of the problem includes three main aspects, namely the meaning of the sign in the Burdah prayer, the connotative and denotative meaning of the da'wah message, and the essence of the da'wah message contained. This study uses a graphical subjective examination technique with an information examination method that involves in-depth data collection, parsing, and analysis. The focus of the research includes the identification of signs, implied meanings, suggestive signs, denotative signs, and symbols in the Burdah prayer. The results of the study show that: first, the signs in the Burdah prayer, such as the symbol of the robe and the black robe, have an important meaning as a medium for conveying the message of protection and spiritual elegance. Second, the connotative and denotative meaning of the da'wah message represents the majesty of the Prophet Muhammad PBUH and the importance of prayer for mercy and salvation from Allah. Third, the da'wah message contained in the Burdah prayer includes the teaching values of aqidah, ethics, and sharia, which are the core of Islamic teachings. The conclusion of this study confirms that the Burdah prayer has a depth of da'wah message that is relevant to modern life, combining elements of art and spirituality to convey the teachings of Islam. This research contributes to the development of da'wah communication studies through digital media.
Cuidados de Enfermería del Catéter Venoso Central durante la Administración de Medicación en Pacientes Críticos
Authors:   Universidad Iberoamericana del Ecuador, Morocho Suárez Dolores Patricia , Soto Quezada Amparo del Rocío , Gallard Muñoz Indyra Emma , Figuera Ávila Paolina Antonieta
Published: December 2024

Introducción: Algunos artículos indican que los cuidados de enfermería durante la
administración de medicación por catéter venoso central son esenciales, con el pasar del tiempo
han ido evolucionando para garantizar la permeabilidad del CVC. Son necesarios algunos
cuidados como la utilización de la solución adecuada, la realización de la técnica correcta
para lavar y bloquear el dispositivo, de acuerdo con los protocolos y directrices disponibles,
permitiendo la prevención de su oclusión, manejo de lúmenes, medicación de riesgo así como
establecer protocolos institucionales para el correcto uso del catéter venoso central durante
la administración de medicación. Objetivo: Comparar los cuidados de enfermería del CVC
durante la administración de medicación en pacientes críticos. La metodología es de tipo
cualitativa, corresponde a una revisión comparativa en la que se han considerado los últimos
5 años, bajo el método de revisión documental PRISMA. Resultados: Se evidencia que los
profesionales de enfermería tienen mínimo margen de error en el uso correcto de lúmenes,
mientras que otros resaltan importancia del lavado de manos previa administración así como
el uso de clorhexidina al 2 %. Algunos estudios sugieren la utilización de heparina para lograr
mayor permeabilidad del catéter. Conclusión: Entre las actividades relacionadas a fallas durante
la administración de medicación por CVC se identifican, la falta de apego a la normatividad y
estandarización institucional, falta de capacitación continua así como auto preparación, además
la rotación continua del personal de enfermería, e ingreso de nuevo personal que quizá no este
familiarizado con el uso del CVC.
Percepción de los Factores de Riesgos en los Trabajadores de la Construcción
Authors:   Universidad Iberoamericana del Ecuador, Jiménez Juan Carlos , Cabrera Richard Andrés , Figuera Ávila Paolina Antonieta
Published: December 2024

El oficio de la construcción está asociado a una serie de factores de riesgo que comprometen
la seguridad y la vida de los trabajadores. En Ecuador, los trabajadores de la construcción enfrentan
una exposición constante a estos riesgos, lo que se refleja en las alarmantes estadísticas
de accidentes laborales. De acuerdo con el Instituto Ecuatoriano de Seguridad Social (IESS),
la construcción es uno de los sectores con los índices más altos de accidentes, muchos de los
cuales están relacionados con caídas de altura, lesiones por maquinaria pesada y la exposición a
sustancias tóxicas. El objetivo central de esta investigación es analizar la percepción de los factores
de riesgo entre los trabajadores del sector. Para ello, se utilizó una metodología cualitativa,
basada en una revisión sistemática bajo el protocolo PRISMA 2020. Los resultados obtenidos
muestran que el 78% de los trabajadores con menos de 2 años de experiencia en la construcción
reportaron una percepción baja sobre los riesgos de accidentes, en contraste con solo el 32% de
los trabajadores con más de 10 años de experiencia, quienes compartieron esa misma percepción.
En conclusión, es fundamental que las empresas constructoras implementen programas de
formación continua y estrategias que promuevan una cultura de seguridad, con el fin de reducir
los riesgos inherentes al sector. Esto no solo garantizaría la seguridad y el bienestar de los trabajadores,
sino que también contribuiría a mejorar la eficiencia, eficacia y productividad de las
constructoras como empresas.
Desafíos en el Desarrollo de Competencias de Liderazgo en los Internos Rotativos de la Carrera de Enfermería
Authors: Gessa Gálvez Meybol María , Gavilánez Silva Graciela Grimaneza , Trujillo Redrobán Karol Joseth
Published: December 2024

El desarrollo de competencias de liderazgo es fundamental para los estudiantes de enfermería,
especialmente durante su periodo de internado rotativo, donde enfrentan retos prácticos y emocionales.
Por lo tanto, el propósito de esta investigación es analizar los desafíos en el desarrollo
de las competencias de liderazgo que deben tener los internos rotativos de la carrera de enfermería.
La metodología empleada en esta investigación se enmarco en un enfoque cualitativo
de tipo revisión sistemática, donde se estableció el método PRISMA 2020, como estrategia de
análisis con la finalidad de sustentar la investigación mediante la revisión exhaustiva de estudios
relacionados con el tema. Los resultados revelan que los internos rotativos de enfermería
de la Universidad Iberoamericana del Ecuador enfrentan desafíos significativos en el desarrollo
de sus competencias de liderazgo, como la falta de experiencia práctica y el estrés emocional,
en conclusión es crucial implementar programas de formación y apoyo durante el internado
rotativo para fortalecer las competencias de liderazgo de los estudiantes, promoviendo su autoconfianza
y capacidad de toma de decisiones en contextos de alta presión.
ПРО ВИКОНАННЯ У 2024 р. ПРОГРАМИ СПІЛЬНОЇ ДІЯЛЬНОСТІ НАЦІОНАЛЬНОЇ АКАДЕМІЇ НАУК УКРАЇНИ ТА НАЦІОНАЛЬНОЇ АКАДЕМІЇ ПЕДАГОГІЧНИХ НАУК УКРАЇНИ НА 2023-2025 рр.
Authors: Kremen Vasyl , Lugovyi Volodymyr , Topuzov Oleh , Reheilo Iryna
Published: December 2024

У статті висвітлено основні результати виконання у 2024 р. Програми спільної діяльності Національної академії наук України та Національної академії педагогічних наук України на 2023-2025 роки, представлені на засіданні Президії НАПН України 19 грудня 2024 р. Продовження реалізації у 2024 р. Програми спільної діяльності НАН України та НАПН України на 2023-2025 роки здійснювалося у складних умовах воєнного стану, перспективних завдань для повоєнного відновлення та євроінтеграції, з метою посилення результативності та розвитку освітньо-наукового потенціалу країни.Охарактеризовано основні результати виконання запланованих Програмою заходів співпраці, серед яких взаємодія дослідницьких інфраструктур; проведення комплексних досліджень; спільна участь у науково-експертній діяльності, підготовці законотворчих ініціатив у сфері науки та освіти, складі редколегій наукових періодичних видань; підготовка наукових і навчальних видань; проведення тематичних науково-комунікаційних та виставкових заходів з питань розвитку освіти і науки тощо. Окреслено перспективні завдання для наукової і освітньої сфер, пов’язані передусім з потребами забезпечення національної єдності суспільства, воєнного потенціалу держави, повоєнного відновлення країни, її євроінтеграції, що потребують нагальної уваги та можуть бути вирішені у співпраці НАН України та НАПН України.
ПРО ВИКОНАННЯ У 2024 р. ПЛАНУ НАЦІОНАЛЬНОЇ АКАДЕМІЇ ПЕДАГОГІЧНИХ НАУК УКРАЇНИ ЩОДО ВІДКРИТОЇ НАУКИ
Authors: Kremen Vasyl , Lugovyi Volodymyr , Topuzov Oleh , Reheilo Iryna
Published: December 2024

Висвітлено основні результати виконання у 2024 р. Плану заходів Національної академії педагогічних наук України щодо відкритої науки, затвердженого постановою Президії НАПН України відповідно до розпорядження Кабінету Міністрів України «Про затвердження національного плану щодо відкритої науки» від 8 жовтня 2022 р. № 892-р. Окреслено найважливіші результати виконання Плану заходів у 2024 р., серед яких: забезпечення відкритого доступу до наукових результатів та науково-технічної інформації; створення умов для проведення ефективної роботи з науково-технічною інформацією та об’єктами дослідницької інфраструктури, що наявні у відкритому доступі; популяризація науки, поширення наукових знань та залучення громадян до участі в науковій та науково-технічній діяльності; підвищення рівня поінформованості та формування компетентності з питань відкритої науки та ін.
Machine learning prediction of hepatic encephalopathy for long-term survival after transjugular intrahepatic portosystemic shunt in acute variceal bleeding
Authors: Liu De-Jia , Jia Li-Xuan , Zeng Feng-Xia , Zeng Wei-Xiong , Qin Geng-Geng , Peng Qi-Feng , Tan Qing , Zeng Hui , Ou Zhong-Yue , Kun Li-Zi , Zhao Jian-Bo , Chen Wei-Guo
Published: December 2024

BACKGROUND

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for managing complications of portal hypertension, particularly acute variceal bleeding (AVB). While effective in reducing portal pressure and preventing rebleeding, TIPS is associated with a considerable risk of overt hepatic encephalopathy (OHE), a complication that significantly elevates mortality rates.

AIM

To develop a machine learning (ML) model to predict OHE occurrence post-TIPS in patients with AVB using a 5-year dataset.

METHODS

This retrospective single-center study included 218 patients with AVB who underwent TIPS. The dataset was divided into training (70%) and testing (30%) sets. Critical features were identified using embedded methods and recursive feature elimination. Three ML algorithms-random forest, extreme gradient boosting, and logistic regression-were validated via 10-fold cross-validation. SHapley Additive exPlanations analysis was employed to interpret the model’s predictions. Survival analysis was conducted using Kaplan-Meier curves and stepwise Cox regression analysis to compare overall survival (OS) between patients with and without OHE.

RESULTS

The median OS of the study cohort was 47.83 ± 22.95 months. Among the models evaluated, logistic regression demonstrated the highest performance with an area under the curve (AUC) of 0.825. Key predictors identified were Child-Pugh score, age, and portal vein thrombosis. Kaplan-Meier analysis revealed that patients without OHE had a significantly longer OS (P = 0.005). The 5-year survival rate was 78.4%, with an OHE incidence of 15.1%. Both actual OHE status and predicted OHE value were significant predictors in each Cox model, with model-predicted OHE achieving an AUC of 88.1 in survival prediction.

CONCLUSION

The ML model accurately predicts post-TIPS OHE and outperforms traditional models, supporting its use in improving outcomes in patients with AVB.
Gel immersion in endoscopy: Exploring potential applications
Authors: Sato Hiroki , Kawabata Hidemasa , Fujiya Mikihiro
Published: December 2024

The challenge of effectively eliminating air during gastrointestinal endoscopy using ultrasound techniques is apparent. This difficulty arises from the intricacies of removing concealed air within the folds of the gastrointestinal tract, resulting in artifacts and compromised visualization. In addition, the overlap of folds with lesions can obscure their depth and size, presenting challenges for an accurate assessment. Conversely, in intricately folded regions of the gastrointestinal tract, such as the stomach, intestine, and colon, insufficient delivery of air or CO2 into the cavity impedes luminal expansion, hindering the accurate visualization of lesions concealed within the folds. Although this underscores the requirement for substantial airflow, excessive airflow can hinder visualization of bleeding lesions and other abnormalities. Considering these challenges, an ideal endoscopic device would facilitate the observation of lesions without the requirement for air or CO2 delivery whereas, ensuring optimal expansion of the gastrointestinal tract. Recently, transparent gels with specific viscosities have been employed more frequently to address this issue. This review aims to elucidate how these gels address these challenges and provide a solution for enhanced endoscopic visualization.
Exploring the therapeutic potential of glucagon-like peptide 1 agonists in metabolic disorders
Authors: Cortés-Martín Adrián , Plaza-Diaz Julio
Published: December 2024

This article comments on the work by Soresi and Giannitrapani. The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease (MASLD) is the use of glucagon-like peptide 1 receptor agonists, especially when used in combination therapy. However, despite their notable efficacy, these drugs were not initially designed to target MASLD directly. In a groundbreaking development, the Food and Drug Administration has recently approved resmetirom, the first treatment specifically aimed at reducing liver fibrosis in metabolic-associated steatohepatitis. Resmetirom, an orally administered, liver-directed thyroid hormone beta-selective agonist, acts directly on intrahepatic pathways, enhancing its therapeutic potential and marking the beginning of a new era in the treatment of MASLD. Furthermore, the integration of lifestyle modifications into liver disease management is an essential component that should be considered and reinforced. By incorporating dietary changes and regular physical exercise into treatment, patients may achieve improved outcomes, reducing the need for pharmacological interventions and/or improving treatment efficacy. As a complement to medical therapies, lifestyle factors should not be overlooked in the broader strategy for managing MASLD.
Application of ultrasound elastography and splenic size in predicting post-hepatectomy liver failure: Unveiling new clinical perspectives
Authors: Xu Shan , Zhang Tao , He Bin-Bo , Liu Jie , Kong Tao , Zeng Qing-Yu
Published: December 2024

In this article, we discuss the study by Cheng et al , published in the World Journal of Gastroenterology , focusing on predictive methods for post-hepatectomy liver failure (PHLF). PHLF is a common and serious complication, and accurate prediction is critical for clinical management. The study examines the potential of ultrasound elastography and splenic size in predicting PHLF. Ultrasound elastography reflects liver functional reserve, while splenic size provides additional predictive value. By integrating these factors with serological markers, we developed a comprehensive prediction model that effectively stratifies patient risk and supports personalized clinical decisions. This approach offers new insights into predicting PHLF. These methods not only assist clinicians in identifying high-risk patients earlier but also provide scientific support for personalized treatment strategies. Future research will aim to validate the model's accuracy with larger sample sizes, further enhancing the clinical application of these non-invasive indicators.
Prediction of posthepatectomy liver failure in patients with hepatocellular carcinoma through ultrasound elastography
Authors: Ma Yan-Qing , Xu Xi-Ren , Li Jie , Lin Yi , Guan Zheng
Published: December 2024

In this article, we comment on the article by Cheng et al published in recently. Posthepatectomy liver failure (PHLF) remains a leading cause of hepatectomy-related mortality and can be evaluated according to liver reserve function. Liver stiffness (LS) measured by ultrasonic elastography and spleen area demonstrate a strong correlation with hepatic proliferation, fibrosis, and portal vein congestion, thus indirectly reflecting liver reserve function. This article highlights a meticulous study aimed at investigating the potential of two-dimensional shear wave elastography in assessing LS, as well as its integration with spleen area, surgical factors, and laboratory indicators, for predicting the risk of PHLF in hepatocellular carcinoma patients. In this article, we discussed the non-invasive elastography modality by ultrasound and magnetic resonance imaging to assess LS. Based on literature data, we subsequently suggested that several risk factors may contribute to PHLF, including excessive intrahepatic neutrophil accumulation, the formation of neutrophil extracellular traps, end-stage liver disease scores, and albumin-bilirubin scores. Therefore, a more comprehensive study incorporating detailed information requires further investigation.
Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease
Authors: Sun Zhi-Gang , Chen Shao-Xuan , Sun Bai-Long , Zhang Da-Kui , Sun Hong-Liang , Chen Huang , Hu Yu-Wan , Zhang Tong-Yin , Han Zi-Han , Wu Wen-Xiao , Hou Zhi-Yong , Yao Li , Jie Jian-Zheng
Published: December 2024

BACKGROUND

Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with decreased survival in colorectal cancer (CRC), but its significance in N1c stage remains to be clearly defined.

AIM

To evaluate LVI and PNI as potential prognostic indicators in N1c CRC.

METHODS

We retrospectively identified 107 consecutive patients who had CRC with N1c disease radically resected at our hospital. Tumors were reviewed for LVI and PNI by one pathologist blinded to the patients’ outcomes. Disease-free survival (DFS), overall survival (OS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method, with LVI and PNI prognosis differences determined by multivariate analysis using the Cox multiple hazards model. Results were compared using log-rank test. The receiver operating characteristic (ROC) curve was used to evaluate the prognostic predictive ability.

RESULTS

The median follow-up time was 63.17 (45.33-81.37) months for DFS, with 33.64% (36/107) of patients experiencing recurrence; 21.5% of tumors were found to be LVI positive and 44.9% PNI positive. The 5-year DFS rate was greater for patients with LVI-negative tumors compared with LVI-positive tumors (74.0% vs 35.6%), and PNI was similar (82.5% vs 45.1%). On multivariate analysis, LVI [hazard ratio (HR) = 3.368, 95% confidence interval (CI): 1.628-6.966, P = 0.001] and PNI (HR = 3.055, 95%CI: 1.478-6.313, P = 0.002) were independent prognostic factors for DFS. All patients could be divided into three groups of patients with different prognosis according to LVI and PNI. The 5-year ROC curve for LVI, PNI and their combination prediction of DFS was 0.646, 0.709 and 0.759, respectively. Similar results were seen for OS and CSS.

CONCLUSION

LVI and PNI could serve as independent prognostic factors of outcomes in N1c CRC patients. Patients with LVI or PNI should be given more attention during treatment.
Capsule endoscopy: Do we still need it after 24 years of clinical use?
Authors: Tawheed Ahmed , Ismail Alaa , Amer Mohab S , Elnahas Osama , Mowafy Tawhid
Published: December 2024

In this letter, we comment on a recent article published in the World Journal of Gastroenterology by Xiao et al , where the authors aimed to use a deep learning model to automatically detect gastrointestinal lesions during capsule endoscopy (CE). CE was first presented in 2000 and was approved by the Food and Drug Administration in 2001. The indications of CE overlap with those of regular diagnostic endoscopy. However, in clinical practice, CE is usually used to detect lesions in areas inaccessible to standard endoscopies or in cases of bleeding that might be missed during conventional endoscopy. Since the emergence of CE, many physiological and technical challenges have been faced and addressed. In this letter, we summarize the current challenges and briefly mention the proposed methods to overcome these challenges to answer a central question: Do we still need CE?
What is the role of nonalcoholic fatty liver disease in pulmonary carcinoma development?
Authors: Pan Qin , Xu Qing-Yang , Zhang Lang-Hua , He Ya-Fang
Published: December 2024

This article summarizes the epidemiological characteristics and clinical manifestations of nonalcoholic fatty liver disease (NAFLD). The incidence of NAFLD has been increased dramatically and become the leading cause of chronic liver disease worldwide. In addition to its adverse outcomes of liver fibrosis, cirrhosis, and hepatocellular carcinoma, and related complications, NAFLD has recently been found to be associated with the high-risk extrahepatic carcinomas, such as various types of lung cancer (i.e ., lung adenocarcinoma, squamous cell carcinoma, and small cell lung cancer). The presence of hepatic steatosis also predisposes lung cancer to liver metastasis, but has better response to immune checkpoint inhibitors. Whether other factors (i.e ., gender, smoking, etc .) are associated with NAFLD and lung cancer remains controversial. We also comment on the reciprocal relationships between NAFLD and components of metabolic syndrome. Most metabolic syndrome components are suggested to facilitate lung cancer development via activating insulin/insulin-like growth factor axis. In addition, suppressed anti-tumor immunity and accelerated tumor progression could be attributed to the cell-specific metabolic reprogramming in condition of high-fat diet and related obesity. These findings may reveal the role of NAFLD in pulmonary carcinoma and help develop new treatment strategies for this disease.
Unlocking the secrets of the human gut microbiota: Comprehensive review on its role in different diseases
Authors: Paul Jibon Kumar , Azmal Mahir , Haque ANM Shah Newaz Been , Meem Meghla , Talukder Omar Faruk , Ghosh Ajit
Published: December 2024

The human gut microbiota, a complex and diverse community of microorganisms, plays a crucial role in maintaining overall health by influencing various physiological processes, including digestion, immune function, and disease susceptibility. The balance between beneficial and harmful bacteria is essential for health, with dysbiosis - disruption of this balance - linked to numerous conditions such as metabolic disorders, autoimmune diseases, and cancers. This review highlights key genera such as Enterococcus , Ruminococcus , Bacteroides , Bifidobacterium , Escherichia coli , Akkermansia muciniphila , Firmicutes (including Clostridium and Lactobacillus ), and Roseburia due to their well-established roles in immune regulation and metabolic processes, but other bacteria, including Clostridioides difficile , Salmonella , Helicobacter pylori , and Fusobacterium nucleatum , are also implicated in dysbiosis and various diseases. Pathogenic bacteria, including Escherichia coli and Bacteroides fragilis , contribute to inflammation and cancer progression by disrupting immune responses and damaging tissues. The potential for microbiota-based therapies, such as probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions, to improve health outcomes is examined. Future research directions in the integration of multi-omics, the impact of diet and lifestyle on microbiota composition, and advancing microbiota engineering techniques are also discussed. Understanding the gut microbiota’s role in health and disease is essential for formulating personalized, efficacious treatments and preventive strategies, thereby enhancing health outcomes and progressing microbiome research.
First report of Acutaspis oliveirai (Lepage & Giannotti, 1942) (Hemiptera: Diaspididae) in Central Brazil: occurrence on Myrsine guianensis (Aubl.) Kuntze (Primulaceae) in the Brazilian Cerrado
Authors: Castro Marcelo T. , Montalvão Sandro C. L. , Wolff Vera R. S.
Published: December 2024

Recent research shows that the Cerrado has a great diversity of scale insects (Insecta: Hemiptera: Coccomorpha) in association with native plants. This work aimed to report the occurrence of Acutaspis oliveirai (Lepage & Giannotti, 1942) (Hemiptera: Diaspididae) found for the first time in Central Brazil and in plants of Myrsine guianensis (Primulaceae), a common species in the Brazilian Cerrado, that has potential for use in landscaping and the recovery of degraded areas. This is the first report of the occurrence of A. oliveirai in a native plant of the Cerrado biome and in the Central Brazil. Acutaspis oliveirai individuals were found on the leaf surface of M. guianensis leaves in two locations in the Federal District, Brazil, causing irregular yellowing and chlorotic spots throughout the leaf blade.
How do manipulation checks interfere with the inference of causal relationships?
Authors: Han Yuhwa , Lee Wooyeol
Published: December 2024

This study investigates the performance of mediation analyses, including manipulation check variables, in experimental studies where manipulated psychological attributes are independent variables. We simulated the level of manipulation intensities and measurement errors of the manipulation check variable to test the validity of the analytic practice. Our results showed that when manipulation is successful and measurement error is low, mediation analyses with the manipulation check variable revealed an unstable path coefficient and standard error. Moreover, many of the detected indirect effects were inconsistent mediation situations. However, when individual differences in psychological attributes remained within the condition (low manipulation intensity) and the manipulation check variable contained low measurement error, the indirect effect indicated the validity of the manipulation. We discuss the implications of our findings for the use of manipulation checks in experimental research.
Analysis of Trends in Train Accident-Related News Using Topic Modeling
Authors:   The Korean Data Analysis Society, Lee Wonjae , Park Chanwoo , Kang Seongkeun , Yoon Sanghoo
Published: December 2024

Train accidents cause significant human casualties and property damage, and various accidents continue to occur despite technological advancements. The media reports these accidents, contributing to public safety awareness and policy changes. This paper aims to analyze news articles related to train accidents over a decade, from 2014 to 2023, to develop prevention and response strategies. By analyzing the social discourse and media coverage trends of train accidents through news articles, this study comprehensively examines not only the accidents but also changes in societal perception and policy responses. Using LDA topic modeling, we derived five optimal topics: (1) train accidents in South Korea, (2) major international train accidents, (3) screen door accidents, (4) train-related disasters and corresponding measures, and (5) safety measures for preventing train accidents. This research provides a comprehensive perspective on train safety through news article analysis, examining not only the accidents themselves but also changes in social perception and policy responses by analyzing media reporting trends. We expect this study to contribute to the development of train safety policies and guidance for media reporting directions.
Study on Rainfall Threshold Setting for Deep Convolutional Generative Adversarial Networks in Simulating Heavy Rainfall over the Korean Peninsula
Authors:   The Korean Data Analysis Society, Kang So Ra , Yoon Seongsim , Yoon Sanghoo
Published: December 2024

To effectively respond to the increasing damage caused by extreme rainfall due to climate change, it is crucial to accurately estimate the rainfall threshold that triggers heavy rain advisories and warnings. This study aims to simulate extreme rainfall patterns associated with monsoons and typhoons over the Korean Peninsula by using daily cumulative rainfall data with a 5km spatial resolution. First, a maximum threshold was determined to represent the characteristics of extreme rainfall data best and a Deep Convolutional Generative Adversarial Network (DCGAN) model was proposed to simulate such extreme rainfall events. The quality of the generated rainfall images was evaluated using metrics such as Frechet Inception Distance (FID), reconstruction loss, and Mean Absolute Percentage Error (MAPE). Analysis results indicated that setting the threshold at the top 0.01% of rainfall events achieved the most effective trade-off in preserving information. The DCGAN model proved useful for quantitative rainfall estimation in monsoon and typhoon scenarios, showing superior performance across all metrics, especially for events with rainfall amounts below 200mm/day, compared to conventional models. The generated images effectively captured localized rainfall patterns and are expected to provide valuable information for predicting and preparing for potential natural disasters in specific areas.
Analysis of the Applicability of Dimensionality Reduction Techniques in Stock Portfolio Construction
Authors:   The Korean Data Analysis Society, Lee Hyemin
Published: December 2024

This study aims to overcome the limitations of previous research that utilized only a small number of financial indicators and proposes a method to comprehensively utilize all available financial data at the time of investment. To implement this effectively, we propose a Sliced Inverse Regression (SIR) model, a form of sufficient dimension reduction. In this study, we compare the returns of portfolios constructed using dimensionality reduction with those of market indices (KOSPI, KOSDAQ) and portfolios based on previous research (small-cap stocks, low PBR). The results indicate that the portfolio constructed using SIR achieved higher returns (46.1% cumulative over three years) compared to the benchmark portfolios and market indices, demonstrating strong potential for practical investment application. This suggests that the principal components extracted via SIR contain more critical information that can influence future returns than other comparative indicators. However, limitations of this study include the difficulty in providing a financial interpretation of the principal components extracted through dimensionality reduction.
Panel data analysis on the effect of enterprise value-Nonghyup Cooperative
Authors:   The Korean Data Analysis Society, Kim Hongkyoung , Kang Seongjun , Kim Jeongil
Published: December 2024

Nonghyup continues to grow and the fields it engages in are becoming more diverse and specialized. Accordingly, efficient evaluation based on appropriate standards are becoming important. However, as the company's size grows, efficient analysis of its internal structure becomes difficult. This study conducted panel data analysis to select an appropriate panel data model to evaluate the value of Nonghyup. As a result, the two-factor random effects model was selected as the optimal model, and based on this, the final model was selected using the backwards elimination technique to select significant variables. As a result, the greater the cash, deposits, number of union members, and loans, the more positive influence it had on net profit, while the more tangible assets and number of executives had a weak negative influence. The limitations of this study are that it was conducted with insufficient observations and limited variables provided only by Nonghyup. In future research, we expect that various explanatory variables will be supplemented and analyzed along with panel data from several large companies.
Analyzing the Effect of Fund Costs on Open-End Funds Performance Using XAI Technique
Authors:   The Korean Data Analysis Society, Song Minchae , Park Jaeyoung
Published: December 2024

High fund costs, which are discussed as main factors reducing the competitiveness of domestic open-end fund products, have lowered the actual return on investment, leading to stagnation in the open-end fund market. Unlike previous studies, this research focuses on fund management and sales costs to predict the out-performance of domestic open-end funds. Using the latest data, we empirically analyzed the potential occurrence of agency costs between investors and fund family across all types of open-end funds in Korea. Considering the nonlinear relationship between fund costs and returns, we applied XGBoost to predict fund performance using fee rates and used the SHAP method to extract and visualize the feature attribute of cost variables from the XGBoost model. Additionally, we conducted OLS regression analysis to confirm the directional effect of fund costs on returns. The results showed that the effect of fund costs on performance varies by fund type. These findings provide significant insights and empirical evidence supporting the need to improve the fund cost policy in the domestic open-end fund market.
A study on the economic effect of income deduction on OTT subscription fees
Authors:   The Korean Data Analysis Society, Kwon Jihye , Yang Junga , Lee Changu , Kwak Jeongho
Published: December 2024

Income deduction is a deduction for a certain amount of income subject to taxation, and is implemented for the purpose of revitalizing the field in various industries according to various policy judgments. In 2018, the Ministry of Culture introduced an income deduction for cultural expenses such as performances, museums, and art galleries with the aim of enhancing people's cultural enjoyment and revitalizing the cultural industry. Recently, as the OTT industry has grown rapidly enough to be used by 72.0% of the people, discussions have been raised that OTT subscription fees should be included in the scope of the cultural cost income deduction. It is argued that the existing cultural cost deduction had a geographical limitation of space, but since there is no space constraint, the OTT subscription fee income deduction has a large policy effect from a cultural perspective. As the necessity of applying the cultural cost income deduction to OTT subscription fees continues to be raised, it is necessary to systematically analyze the economic ripple effects of the income deduction for OTT subscription fees. Therefore, in this study, in order to determine whether it is politically appropriate to include OTT subscription fees in the cultural cost income deduction range, the economic ripple effects of OTT subscription fees income deduction through the input-output analysis (IO) model used in economics are analyzed and implications are presented.
The Relationship Between Changes in Walking Practice Rate Disparities and Deprivation Index: Using a Generalized additive mixed model
Authors:   The Korean Data Analysis Society, Kim Ahreum , Jang Seunghye , Noh Maengseok , Kim Changhoon
Published: December 2024

The walking practice rate is a health indicator that can be influenced by the physical infrastructure and collective social functions of the places where individuals live and work. It may be affected by various factors, such as individual changes, health policy shifts, improvements in community infrastructure, and analyzing how these factors evolve over time and establishing appropriate strategies is essential. Thus, this study employed a generalized additive mixed model to analyze changes in the walking practice within Busan, including both individual and area-level factors while accounting for the non-linearity of yearly trends. As a result, the findings revealed varying effects of annual changes on regional disparities and identified a cross-level interaction between education level and deprivation index. Especially, the group with education level ranging from no education to middle school, predominantly comprising elderly individuals, demonstrated the physical conditions of areas with high levels of deprivation could potentially have negative effects on the walking practice. The generalized additive mixed model would be a valuable tool for identifying area factors influencing various health-related indicators exhibiting non-linear change patterns.