bluuebunny/crossref_metadata_2025 huggingface dataset:
Endometrial carcinoma: Angiogenesis and review of the role of vascular endothelial growth factor
Authors: Obradović Danilo , Oprić Dejan
Published: February 2023

Endometrial carcinomas (EC) represent the most common malignant tumors of the female reproductive system and the sixth most common in the female population with an increased incidence of morbidity and mortality over the past three decades. In addition to stage, grade and type of tumor, these are the most significant prognostic factors of the biological behavior of EC and in current clinical practice are based on pathohistological examination. The shortcomings of the current histological classification are cited as one of the key limiting factors in further research, as well as in the understanding of EC carcinogenesis and improving therapeutic protocols. A new molecular classification of EC was formulated, based on the analysis of molecular biological features, recognized as highly related to the specific clinical course. Considerable efforts have been made to understand the process of angiogenesis as one of the key processes in tumor growth. The vascular endothelial growth factor (VEGF) family is a group of proangiogenic ligands that play a central role in the process of physiological and pathological angiogenesis. This factor is the most widely investigated angiogenic one as a potential biomarker and target for targeted therapy. After vast research, clinical studies have shown significant advances in the development of anti-angiogenic therapy directed at VEGF, predominantly in the form of combined therapy. In defining therapeutic groups, this therapy relies on the molecular classification of EC. Antiangiogenic therapy is limited to small specific groups of patients, associated with side effects, and numeorus patients who initially responded to targeted therapy develop resistance over time, which indicates the further need for a better understanding of the mechanisms and factors involved in the angiogenic process of EC. Potentially promising advances in the development of targeted therapeutic options for EC can be expected within the integration of molecular features of EC as a factor in the context of histological classification.
Ask the people: Building tourism policies from the perception of residents: The case of Novi Sad European Capital of Culture 2022
Authors: Milenković Nemanja , Vernot-Maksić Ana
Published: February 2023

Tourism destinations need to actively engage all their stakeholders that apart from tourists, service providers, investors, and other, also includes residents that are not always in the focus of decision-makers. However, they can be a strong opponent when showing resentment towards the tourism development or the proposed plans. Therefore, the paper analyses the perception of residents towards the urban spaces of Novi Sad. The city is awarded as the European Capital of Culture for 2021 and therefore reassess its urban settings and tourism policies with respect to the wishes of residents. Data for the research was collected by in-person interviews with 797 local residents. The results show the residents are primarily satisfied with the green/recreational areas, and the most visited point is the city centre. The essential urban markers are Petrovaradin Fortress, The Name of Mary Church, The Matica srpska, The Danube, and Serbian National Theatre. From the practical perspective, the results can enable authorities and tourism officials to identify spatially dependent attributes that are important for the destination image and residents' quality of life.
On the Optimum Ducted Propeller Loading
Authors: Kinnas S. A. , Coney W. B
Published: February 2023

A numerical approach to determine the optimum circulation distribution of a propeller inside a given duct 18 presented. The propeller blades are modelled by lifting lines. The duct is represented in non-linear theory by using a potential based panel method.

The propeller lifting lines are approximated by a finite number of vortex horseshoes. The strengths of the horseshoes are determined by using a numerical nonlinear optimization technique to maximize the propulsor efficiency. The non axisymmetric duct/propeller interactions are included within the design procedure.

Results are presented for propellers designed to operate at various thrust coefficients inside of two different ducts and at several advance ratios.
Acoustic Performance of the Highly Skewed Propeller of a Ro-Ro Container Ship
Authors: Bruggeman J. C. , Huisman A. A.
Published: February 2023

As part of the research programme supported by the National Foundation for co-ordination of Maritime Research in the Netherlands, full scale experiments were performed on board a roll-on roll-off (ro-ro) container ship to determine the acoustic performance of a highly skewed propeller.

Propeller cavitation is an important cause of vibration and noise in the afterbody of present day ships. The highly skewed propeller investigated in the present day ships.

The highly skewed propeller investigated in the present study was predicted to have better cavitation characteristics than a conventional propeller with no loss in propulsion efficiency.

Therefore, the main goal of the experimental programme was to determine the acoustic source strength and frequency spectrum of the fluctuating volume of propeller cavitation.

In addition, vibration levels in the stern of the vessel and sound pressure levels in accommodation and work spaces were recorded.

The present data is compared with:

1. Similar data obtained in 1979 for the same vessel equipped with a conventional propeller; and

2. Semi-empirical predictions of acoustic source strength of propeller cavitation.
Mathematical Model of Segmental Section Propeller Series for Open-Water and Cavitating Conditions Applicable in CAD
Authors: Radojcic D. D.
Published: February 2023

A major purpose of this paper has been directed toward mathematical representation of Gawn-Burrill KCA flat-faced, segmental section propeller series for open-water characteristics and the more difficult problem of representing the cavitating regime. Regression technique was applied and polynomials are given for thrust and torque coefficients for both environments. Selecting of optimal propeller can be accomplished by computer-aided techniques utilizing the mathematical model described herein.
Propeller in Inclined Flow for Fast Craft
Authors: Ruggiero V. , Venturini G.
Published: February 2023

The behavior of a propeller that operates in a uniform flow greatly inclined has been studied, in way to reach the optimization of design thing really important in case of planning craft where the shaft inclination is often considerable.

Before, the influence of inclined flow on the geometric attach angle has been investigated with the following variation of the profile lift coefficient, therefore, individuating the most important parameters in propeller design and their influence on its general characteristics.

Then, calculation method has been introduced to take into account of lift and drag variations along radius and circumference. This method permits, the calculation of thrust, and torque for every position to thrust resultant and the test to the most dangerous cavitation conditions.

In the end has been discussed the design of a propeller for a fast military planing hull in the light of the foregoing.
The influence of Propeller Skew on the Velocity Field and Tip Vortex Shape in the Slipstream of Propellers
Authors: Blaurock J. , Lammers G.
Published: February 2023

In HSVA’s medium-sized cavitation tunnel, an LDV-service (Laser Doppler Velocimeter) was used to measure the three-dimensional flow field in the slipstream of different model propellers. Three propellers were investigated with the same main dimensions except for different skew.

The propellers were designed especially for this investigation. The skew angles were 0 degrees, 21 degrees and 62 degrees. Most measurements were done at a distance of 0.3 D behind the propellers at uniform inflow.
Contrarotating Propellers-Design Theory and Application
Authors: Cox B. D. , Reed A. M.
Published: February 2023

This paper sets forth recent developments in the design theory for contrarotating propellers. The analysis includes a more accurate solution for the optimum circulation distribution than has been previously formulated, it includes prediction of slipstream contraction for the first time, and it includes faster and more accurate methods of computing the mutual interactions between the forward and aft propeller. The addition, the theory has been extended to allow for finite loading at the blade roots and takes into account the effect of the hub boundary. The paper provides numerical predictions of efficiency as a function of thrust loading, advance coefficient, and comparisons between single and contrarotating propellers. Calculations and measurements are also presented for the forces and flow field velocities of a contrarotating propeller designed for uniform flow.
Propeller Hydroelastic Effects
Authors: Atkinson P. , Glover E. J.
Published: February 2023

The paper describes, with examples, the use of lifting surface analysis and finite element stressing procedures to investigate the deflections of propeller blades under load and the influence of these deflections on the performance of the propeller.
Investigation of the Peculiarities of the Metrorhythmic Organization of Onegin's Vocal Part in P.I. Tchaikovsky's Opera "Eugene Onegin"
Authors: Vasheruk Ilya  Ilyich
Published: February 2023

The main attention of the author of the work focuses on the study of temporal structures in the solo episodes of Eugene Onegin. In this work, based on the research of theorists and musicologists, a detailed analysis of metric systems and rhythm formulas in the musical material of the protagonist is carried out. Special attention is paid to the study of the hidden meaning of leit rhythms as means of artistic expression, independent of the melodic-harmonic component of the musical fabric. The author examines in detail such aspects of the topic as accentuation and "broad three-lobe", polyrhythm and polymetry, elements of polyfurcation and fractal processes of shaping, shift of the clock line and higher-order bars. Special attention is paid to the influence of the metrorhythmic side on the figurative and artistic component of the process of creating and developing the plot of an opera performance. The main conclusion of the study is the need to study the regularities of metrorhythmic constructions in vocal parts. This will allow performers to more deeply and comprehensively penetrate deep into the semantic musical structures, get additional opportunities to control the performing apparatus while working on creating an artistic image. This approach is relevant and quite new in terms of the originality of the research perspective, since so far this topic has not been presented in a similar way in the scientific literature. The presence of musical examples, quotations from scientific literature, tables and diagrams turns the work into a visual and easy-to-study scientific material.
The direct flow of charged particles and the global polarization of hyperons in 200 AGeV Au+Au collisions at RHIC
Authors: Jiang Ze-Fang , Wu Xiang-Yu , Yu Hua-Qing , Cao Shan-Shan , Zhang Ben-Wei ,   College of Physics and Electronic Information Engineering, Hubei Engineering University, Xiaogan 432000, China,   Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics (MOE), Central China Normal University, Wuhan 430079, China,   Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China
Published: February 2023

In non-central relativistic heavy-ion collisions, the non-colliding nucleons drag the colliding nucleons along the longitudinal direction asymmetrically, producing a longitudinally tilted quark-gluon plasma (QGP) fireball. Meanwhile, these colliding nuclei deposit a huge initial orbital angular momentum into the system, leading to the polarization of partons inside the QGP along the direction of the total angular momentum. Based on the optical Glauber model, we develop a 3-dimensional initial condition of the tilted QGP. By combining it with the (3+1)-dimensional viscous hydrodynamic model CLVisc, we investigate the directed flow of charged hadrons and the global polarization of \begin{document}$ \Lambda/\bar{\Lambda} $\end{document} hyperons in heavy-ion collisions. Our calculation indicates that the combination of a tilted initial condition of the QGP and the hydrodynamic model can provide a satisfactory description of the directed flow and global polarization observed at RHIC-STAR. This offers a theoretical baseline for using these observables to further constrain the initial geometry and kinematic properties of the nuclear matter created in heavy-ion collisions.
Individual and combined effect of organic eutrophication (DOC) and ocean warming on the ecophysiology of the Octocoral Pinnigorgia flava
Authors: Zelli Edoardo , Simancas-Giraldo Susana Marcela , Xiang Nan , Dessì Claudia , Katzer Nadim Daniel , Tilstra Arjen , Wild Christian
Published: February 2023

Dissolved organic carbon (DOC) enrichment and ocean warming both negatively affect hard corals, but studies on their combined effects on other reef organisms are scarce. Octocorals are likely to become key players in future reef communities, but they are still highly under-investigated with regard to their responses to global and local environmental changes. Thus, we evaluated the individual and combined effects of DOC enrichment (10, 20 and 40 mg L−1 DOC, added as glucose) and warming (stepwise from 26 to 32 °C) on the widespread Indo-Pacific gorgonian Pinnigorgia flava in a 45-day laboratory experiment. Oxygen fluxes (net photosynthesis and respiration), as well as Symbiodiniaceae cell density and coral growth were assessed. Our results highlight a differential ecophysiological response to DOC enrichment and warming as well as their combination. Individual DOC addition did not significantly affect oxygen fluxes nor Symbiodiniaceae cell density and growth, while warming significantly decreased photosynthesis rates and Symbiodiniaceae cell density. When DOC enrichment and warming were combined, no effect on P. flava oxygen fluxes was observed while growth responded to certain DOC conditions depending on the temperature. Our findings indicate that P. flava is insensitive to the individual effect of DOC enrichment, but not to warming and the two stressors combined. This suggests that, if temperature remains below certain thresholds, this gorgonian species may gain a competitive advantage over coral species that are reportedly more affected by DOC eutrophication. However, under the expected increasing temperature scenarios, it is also likely that this octocoral species will be negatively affected, with potential consequences on community structure. This study contributes to our understanding of the conditions that drive phase shift dynamics in coastal coral reef ecosystemds.
The Effect of Corporate Social Responsibility, Company Size and Company Age on the Financial Performance of Manufacturing Companies listed on the Indonesia Stock Exchange (IDX)
Authors: Adriansyah Muhammad Kevin , Purnomo Bely Yosi , Lestari Henny Setyo , Margaretha Farah
Published: February 2023

Aims: This study aims to analyze the effect of Corporate Social Responsibility, company size, and company age on the company's financial performance. Financial performance in this study is focused on Return on Equity and Price to Book Value.

Study Design:  Explanatory Research.

Place and Duration of Study: Indonesia between November 2022 to January 2023.

Methodology: The data used in this study are secondary data sourced from the annual reports of industrial sector manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2017-2021 period. The research sample was selected using the purposive sampling method so that 32 companies were sampled. The data used in this study uses social cost as the basis for calculating CSR, Ln Total Assets as a calculation of company size, the year the company was founded until the research was conducted as a calculation of company age and the DER ratio as a control variable. The data analysis used to test the hypothesis is regression analysis using the Eviews 12 program.

Results: The results showed that CSR significantly affects financial performance. The results also show that the company size variable significantly affects company performance. In addition, the results also show that the age of the company and the control variable debt to equity ratio has no significant effect on financial performance with ROE measurement but have a significant impact on PBV financial performance measurement.

Conclusion: Social activities carried out by the company can impact the company's financial performance, both positively and negatively. Similarly, the size of a company can contribute to its positive or negative financial performance of the company. But on the other hand, the company's age may or may not affect the company's financial performance, as well as the debt-to-equity ratio, which may or may not affect the company's financial performance.
Model Proyeksi Dan Optimalisasi Cash Flow Multi Proyek
Authors: Irpiena Resela , Alifen Ratna Setyawardani , Chandra Herry Pintardi
Published: February 2023

This study aims to create an integrated system that has the ability to project the schedule and cash flow of a multi project situation for construction companies, while optimizing them so that a more efficient schedule and financial planning is achieved. In this study, an efficient construction planning refers to a schedule combination that generates a cash flow with minimum overdraft for the company.This study focuses on utilizing floats from non-critical activities in initial or as-planned schedule. Iteration on the floats is done with evolutionary algorithm optimization method using projects’ durations and credit limit as constraints. The result is a combination of multi project schedules which generates the least amount of overdraft throughout the fiscal year to achieve minimum loans of thecompany.
Analisa Faktor dan Diskriminan terhadap Kepuasan Penghuni Apartemen Sekitar Kampus di Surabaya : Studi Kasus Apartemen The Square, High Point dan Metropolis
Authors: Yuwono Nicko Vincent , Kwanda Timoticin , Rahardjo Jani
Published: February 2023

Minat pembeli dalam membeli apartemen mahasiswa semakin meningkat setiap tahunnya. Namun, pembangunan apartemen yang meningkat pesat ternyata tidak lepas dari berbagai masalah yang timbul. Berbagai masalah yang timbul ini dikhawatirkan dapat menyebabkan penghuni merasa tidak puas dengan hunian mereka. Penelitian ini bertujuan untuk mengetahui faktor yang berpengaruh terhadap kepuasan penghuni apartemen sekitar kampus di Surabaya. Penelitian dimulai dengan menemukan variabel – variabel penyebab kepuasan berhuni melalui studi literatur yang dilanjutkan dengan proses pembagian kuesioner. Proses analisa data dilakukan dengan analisa deskriptif, analisa kepuasan, analisa cluster dan diakhiri dengan uji diskriminan. Hasil penelitian menunjukkan bahwa secara umum penghuni merasa puas dengan hunian mereka. Berdasarkan hasil analisa, didapatkan pula bahwa ada hubungan antara status penghuni ( mahasiswa atau non mahasiswa ) terhadap kualitas layanan dan produk. Hasil analisa faktor membuktikan bahwa benar, kelompok faktor kualitas produk dan layanan berpengaruh terhadap kepuasan berhuni.
Antibiotic Receipt During Outpatient Visits for COVID-19 in the US, From 2020 to 2022
Authors: Wittman Samuel R. , Martin Judith M. , Mehrotra Ateev , Ray Kristin N.
Published: February 2023

This cross-sectional study examines prescribed and filled antibiotics for outpatient COVID-19 treatment among children, adolescents, and adults with commercial insurance.
Benzodiazepine Receptor Agonists Prescribing for Insomnia Among Adults in Primary Health Care Facilities in Beijing, China
Authors: Fu Mengyuan , Zhu Yuezhen , Gong Zhiwen , Li Can , Li Huangqianyu , Shi Luwen , Guan Xiaodong
Published: February 2023

This cross-sectional study examines the benzodiazepine receptor agonists (BZRA) prescribing rate for insomnia among adult patients in primary health care facilities (PHFs) in China.
A partial convolution generative adversarial network for lesion synthesis and enhanced liver tumor segmentation
Authors: Liu Yingao , Yang Fei , Yang Yidong
Published: February 2023

Lesion segmentation is critical for clinicians to accurately stage the disease and determine treatment strategy. Deep learning based automatic segmentation can improve both the segmentation efficiency and accuracy. However, training a robust deep learning segmentation model requires sufficient training examples with sufficient diversity in lesion location and lesion size. This study is to develop a deep learning framework for generation of synthetic lesions with various locations and sizes that can be included in the training dataset to enhance the lesion segmentation performance. The lesion synthesis network is a modified generative adversarial network (GAN). Specifically, we innovated a partial convolution strategy to construct a U‐Net‐like generator. The discriminator is designed using Wasserstein GAN with gradient penalty and spectral normalization. A mask generation method based on principal component analysis (PCA) was developed to model various lesion shapes. The generated masks are then converted into liver lesions through a lesion synthesis network. The lesion synthesis framework was evaluated for lesion textures, and the synthetic lesions were used to train a lesion segmentation network to further validate the effectiveness of the lesion synthesis framework. All the networks are trained and tested on the LITS public dataset. Our experiments demonstrate that the synthetic lesions generated by our approach have very similar distributions for the two parameters, GLCM‐energy and GLCM‐correlation. Including the synthetic lesions in the segmentation network improved the segmentation dice performance from 67.3% to 71.4%. Meanwhile, the precision and sensitivity for lesion segmentation were improved from 74.6% to 76.0% and 66.1% to 70.9%, respectively. The proposed lesion synthesis approach outperforms the other two existing approaches. Including the synthetic lesion data into the training dataset significantly improves the segmentation performance.
Health literacy: Major factor in preventing youth cannabis use
Authors: Knopf Alison
Published: February 2023

Amelia Arria, Ph.D., has focused her research on the impact of substance use and untreated mental health problems among college students specifically, and more broadly, on adolescents. Speaking at this month's annual leadership meeting of Community Anti‐Drug Coalitions of America (CADCA), Arria, a professor in the school of public health at the University of Maryland, talked about the widespread misperceptions of cannabis among college students.
Circadian Disruption in Night Shift Work and Its Association with Chronic Pulmonary Diseases
Authors: Joshi Amey , Sundar Isaac Kirubakaran
Published: February 2023

Globalization and the expansion of essential services over continuous 24 h cycles have necessitated the adaptation of the human workforce to shift‐based schedules. Night shift work (NSW) causes a state of desynchrony between the internal circadian machinery and external environmental cues, which can impact inflammatory and metabolic pathways. The discovery of clock genes in the lung has shed light on potential mechanisms of circadian misalignment in chronic pulmonary disease. Here, the current knowledge of circadian clock disruption caused by NSW and its impact on lung inflammation and associated pathophysiology in chronic lung diseases, such as asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and COVID‐19, is reviewed. Furthermore, the limitations of the current understanding of circadian disruption and potential future chronotherapeutic advances are discussed.
Engineering Multifunctional Polyether Ether Ketone Implant: Mechanics‐Adaptability, Biominerialization, Immunoregulation, Anti‐Infection, Osteointegration, and Osteogenesis
Authors: Ma Hongyun , Han Hao , Zhao Xiaoming , Ma Junping , Qu Xiaoyan , Lou Xiaoxiao , Suonan Angxiu , Lei Bo , Zhang Yingang
Published: February 2023

Polyether ether ketone (PEEK) has become one of the most promising polymer implants in bone orthopedics, due to the biocompatibility, good processability, and radiation resistance. However, the poor mechanics‐adaptability/osteointegration/osteogenesis/antiinfection limits the long‐term in vivo applications of PEEK implants. Herein, a multifunctional PEEK implant (PEEK‐PDA‐BGNs) is constructed through in situ surface deposition of polydopamine‐bioactive glass nanoparticles (PDA‐BGNs). PEEK‐PDA‐BGNs exhibit good performance on osteointegration and osteogenesis in vitro and in vivo, due to their multifunctional properties including mechanics‐adaptability, biominerialization, immunoregulation, anti‐infection, and osteoinductive activity. PEEK‐PDA‐BGNs can show the bone tissue‐adaptable mechanic surface and induce the rapid biomineralization (apatite formation) under a simulated body solution. Additionally, PEEK‐PDA‐BGNs can induce the M2 phenotype polarization of macrophages, reduce the expression of inflammatory factors, promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and improve the osseointegration and osteogenesis ability of the PEEK implant. PEEK‐PDA‐BGNs also show good photothermal antibacterial activity and can kill 99% of Escherichia coli (E. coli) and Methicillin‐resistant Staphylococcus aureus (MRSA), suggesting their potential antiinfection ability. This work suggests that PDA‐BGNs coating is probably a facile strategy to construct multifunctional (biomineralization, antibacterial, immunoregulation) implants for bone tissue replacement.
Direct Synthesis of Ammonia from Nitrate on Amorphous Graphene with Near 100% Efficiency
Authors: Huang Libei , Cheng Le , Ma Tinghao , Zhang Jun‐Jie , Wu Haikun , Su Jianjun , Song Yun , Zhu He , Liu Qi , Zhu Minghui , Zeng Zhiyuan , He Qiyuan , Tse Man‐Kit , Yang Deng‐tao , Yakobson Boris I. , Tang Ben Zhong , Ren Yang , Ye Ruquan
Published: February 2023

Ammonia is an indispensable commodity in the agricultural and pharmaceutical industries. Direct nitrate‐to‐ammonia electroreduction is a decentralized route yet challenged by competing side reactions. Most catalysts are metal‐based, and metal‐free catalysts with high nitrate‐to‐ammonia conversion activity are rarely reported. Herein, it is shown that amorphous graphene synthesized by laser induction and comprising strained and disordered pentagons, hexagons, and heptagons can electrocatalyze the eight‐electron reduction of NO3−to NH3with a Faradaic efficiency of ≈100% and an ammonia production rate of 2859 µg cm−2h−1at −0.93 V versus reversible hydrogen electrode. X‐ray pair‐distribution function analysis and electron microscopy reveal the unique molecular features of amorphous graphene that facilitate NO3−reduction. In situ Fourier transform infrared spectroscopy and theoretical calculations establish the critical role of these features in stabilizing the reaction intermediates via structural relaxation. The enhanced catalytic activity enables the implementation of flow electrolysis for the on‐demand synthesis and release of ammonia with >70% selectivity, resulting in significantly increased yields and survival rates when applied to plant cultivation. The results of this study show significant promise for remediating nitrate‐polluted water and completing the NOxcycle.
A Solution‐Mediated Pathway for the Growth of the Solid Electrolyte Interphase in Lithium‐Ion Batteries
Authors: Esmaeilpour Meysam , Jana Saibal , Li Hongjiao , Soleymanibrojeni Mohammad , Wenzel Wolfgang
Published: February 2023

Lithium‐ion batteries (LIBs) are a widely used battery technology. During the initial LIB cycle, a passivation layer, called the solid electrolyte interphase (SEI), forms on the anode surface, which plays a crucial role in the performance and long‐term cyclability of LIBs. The overall mesoscale mechanisms of SEI formation and its composition remain elusive both in experimental and computational approaches. Here a multiscale approach to comprehensively characterize the growth and composition of the SEI based on a chemistry‐specific reaction network is presented. Generating an ensemble of over 50 000 simulations representing different reaction conditions, it is found that the organic SEI forms and grows in a solution‐mediated pathway by aggregation of SEI precursors far away from the surface via a nucleation process. The subsequent rapid growth of these nuclei leads to the formation of a porous layer that eventually covers the surface. This finding offers a solution to the paradoxical situation that SEI constituents can form only near the surface, where electrons are available, but does not stop growing when this narrow region is covered. The study is able to identify the key reaction parameters that determine SEI thickness, which pave the way to optimize battery performance and lifetime.
Development of cyanate ester‐based shape memory composite reinforced by multi‐walled carbon nanotube modified with silicon dioxide
Authors: Li Zhihua , Guo Ziteng , Yang Yu
Published: February 2023

Cyanate ester‐based shape memory composites with superior mechanical properties and good shape memory performance are needed in the aerospace field. In this work, we utilized a simple sol–gel method to fabricate multi‐walled carbon nanotubes coated with silica (MWCNT@SiO2), which were used to construct a cyanate ester‐based shape memory composite (SMPC). The moisture resistance of SMPC was improved by the introduction of MWCNT@SiO2. MWCNT@SiO2 had an efficient enhancement effect on the mechanical strength and toughness of SMPC, and the SMPC exhibited the best mechanical properties with 0.9 wt% loading of MWCNT@SiO2, which was associated with the dispersion of MWCNT@SiO2 in the resin matrix. Compared to neat cyanate ester and epoxidized hydroxyl‐terminated polybutadiene resin matrix, it was found that the storage modulus of SMPC increased and the values of glass transition temperatures decreased by incorporation of MWCNT@SiO2. Meanwhile, the SMPC retained good shape memory performance, corresponding to high shape fixity ratio and shape recovery ratio (over 98% after 10 test cycles). The addition of MWCNT@SiO2 accelerated the shape memory progress of SMPC.
Banxia Xiexin decoction ameliorates dextran sulfate sodium (DSS)‐induced ulcerative colitis via inhibiting serine‐threonine protein kinase (Akt)/mitogen‐activated protein kinase (MAPK) signaling pathway
Authors: Ji Wanli , Liu Wangzhenzu , Huo Yan , Hu Cheng , Zhang Yifan
Published: February 2023

Banxia Xiexin decoction (BXD), a traditional Chinese medicine, was widely used in treating ulcerative colitis (UC). However, the active components of BXD and its mechanism in UC remain elusive. Therefore, we used network pharmacology in vivo experiments, molecular docking, and surface plasmon resonance strategy (SPR) to uncover BXD's potential mechanism. A UC rat model was established by orally administering 7% dextran sulfate sodium (DSS) in drinking water, BXD and palmatine were orally administered for 7 days. Network pharmacology was used to investigate the main bioactive components and crucial targets of BXD in treating UC. Molecular docking was used to investigate interactions between components and crucial targets, verifying the results by SPR. By network pharmacology predicting, 20 active components and 44 candidate anti‐UC targets of BXD were identified, and the crucial proteins were screeded from PPI network, including extracellular regulated protein kinases (ERK), AKT1, and tumor necrosis factor‐α (TNF). In addition, some key active components (palmatine, sexangularetin, and skullcapflavone II) were screened out from the active components‐targets network. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and in vivo experiments showed that protein‐serine‐threonine kinase (Akt)/MAPK pathway was involved in BXD treatment for UC; BXD and palmatine significantly ameliorated the severity of DSS‐induced UC in rats. Our study might assist in further investigation of the active components in Chinese medicine.
“Just add small molecules” cell‐free protein synthesis: CombiningDNAtemplate and cell extract preparation into a single fermentation
Authors: Smith Sydney A. , Lindgren Caleb M. , Ebbert Landon E. , Free Tyler J. , Nelson J. Andrew D. , Simonson Katelyn M. , Hunt J. Porter , Bundy Bradley C.
Published: February 2023

Cell‐free protein synthesis (CFPS) is a versatile biotechnology platform enabling a broad range of applications including clinical diagnostics, large‐scale production of officinal therapeutics, small‐scale on‐demand production of personal magistral therapeutics, and exploratory research. The shelf stability and scalability of CFPS systems also have the potential to overcome cost and infrastructure challenges for distributing and using essential medical tests at home in both high‐ and low‐income countries. However, CFPS systems are often more time‐consuming and expensive to prepare than traditional in vivo systems, limiting their broader use. Much work has been done to lower CFPS costs by optimizing cell extract preparation, small molecule reagent recipes, and DNA template preparation. In order to further reduce reagent cost and preparation time, this work presents a CFPS system that does not require separately purified DNA template. Instead, a DNA plasmid encoding the recombinant protein is transformed into the cells used to make the extract, and the extract preparation process is modified to allow enough DNA to withstand homogenization‐induced shearing. The finished extract contains sufficient levels of intact DNA plasmid for the CFPS system to operate. For a 10 mL scale CFPS system expressing recombinant sfGFP protein for a biosensor, this new system reduces reagent cost by more than half. This system is applied to a proof‐of‐concept glutamine sensor compatible with smartphone quantification to demonstrate its viability for further cost reduction and use in low‐resource settings.
Palbociclib (PD 0332991) Interaction with Kinases. Theoretical and Comparative Molecular Docking Study
Authors: Aceves‐Hernández Juan M. , Inés Nicolás Vázquez María , Luis Garza Rivera José , Espinoza Godínez Angélica , Mateo Flores Juan , de Jesús Cruz Guzmán José , Castaño Víctor M.
Published: February 2023

The optimized geometry of palbociclib, (PD 0332991) (8‐cyclopentyl‐6‐ethanoyl‐5‐methyl‐2‐(5‐(piperazin‐1‐yl)pyridin‐2‐ylamino)pyrido[2,3‐d]pyrimidin‐7(8H)‐one), electrostatic potential map, molecular orbitals were calculated using the density functional theory. The geometry was used in a molecular docking study of palbociclib‐kinase complexes, results could be explained by the charge of the nitrogen and oxygen atoms within the palbociclib. Energy gap of HOMO‐LUMO surfaces, could help to explain the reactivity of the ligand and the hydrogen bonding with three different kinases, two of CDK6 and one of CDK4 type. Docking results are similar and complementary with literature reports using molecular dynamics, were hydrogen bonding was obtained and analyzed. The promiscuity of three kinases with palbociclib was detected by the docking results, thus, palbociclib could be used in other types of cancer besides myeloid leukemia. Some similarities are found with CDK4/CDK6 kinases which allow us to determine that palbociclib could be used to control other resistant inhibitor types of cancer.
Identification of Four New Chemical Series of Small Drug‐Like Natural Products as Potential Neuropilin‐1 Inhibitors by Structure‐Based Virtual Screening: Pharmacophore‐Based Molecular Docking and Dynamics Simulation
Authors: Sabki Abdellah , Khelifi Lakhdar , Kameli Abdelkrim , Baali Salim
Published: February 2023

Neuropilin‐1 (NRP‐1), a surface transmembrane glycoprotein, is one of the most important co‐receptors of VEGF‐A165 (vascular endothelial growth factor) responsible for pathological angiogenesis. In general, NRP‐1 overexpression in cancer correlates with poor prognosis and more tumor aggressiveness. NRP‐1 role in cancer has been mainly explained by mediating VEGF‐A165‐induced effects on tumor angiogenesis. NRP‐1 was recently identified as a co‐receptor and an independent gateway for SARS‐CoV‐2 through binding subunit S2 of Spike protein in the same way as VEGF‐A165. Thus, NRP‐1 is of particular value as a target for cancer therapy and other angiogenesis‐dependent diseases as well as for SARS‐CoV‐2 antiviral intervention. Herein, The Super Natural II, the largest available database of natural products (∼0.33 M), pre‐filtered with drug‐likeness criteria (absorption, distribution, metabolism and excretion/toxicity), was screened against NRP‐1. NRP‐1/VEGF‐A165 interaction is one of protein‐protein interfaces (PPIs) known to be challenging when approached in‐silico. Thus, a PPI‐suited multi‐step virtual screening protocol, incorporating a derived pharmacophore with molecular docking and followed by MD (molecular dynamics) simulation, was designed. Two stages of pharmacophorically constrained molecular docking (standard and extra precisions), a mixed Torsional/Low‐mode conformational search and MM‐GBSA ΔG binding affinities calculation, resulted in the selection of 100 hits. These 100 hits were subjected to 20 ns MD simulation, that was extended to 100 ns for top hits (20) and followed by post‐dynamics analysis (atomic ligand‐protein contacts, RMSD, RMSF, MM‐GBSA ΔG, Rg, SASA and H‐bonds). Post‐MD analysis showed that 19 small drug‐like nonpeptide natural molecules, grouped in four chemical scaffolds (purine, thiazole, tetrahydropyrimidine and dihydroxyphenyl), well verified the derived pharmacophore and formed stable and compact complexes with NRP‐1. The discovered molecules are promising and can serve as a base for further development of new NRP‐1 inhibitors.
Benefits of mechanical aspiration of pulmonary artery thrombi regardless of clot location
Authors: Bowers Terry R. , Goldstein James A.
Published: February 2023

Key Points

Proximal pulmonary embolism reduces trans‐pulmonary flow and induces RV Strain which induces hemodynamic compromise

Aspiration Thrombectomy improves pulmonary flow by reducing pulmonary vascular resistance and relieving RV Strain

Mechanical aspiration of proximal pulmonary artery clot is beneficial for both main and branch thrombi
Radix+: High‐throughput georeferencing and data ingestion over voluminous and fast‐evolving phenotyping sensor data
Authors: Mitra Saptashwa , Roselius Maxwell , Andrade‐Sanchez Pedro , McKay John K. , Pallickara Sangmi Lee
Published: February 2023

Remote sensing of plant traits and their environment facilitates non‐invasive, high‐throughput monitoring of the plant's physiological characteristics. However, voluminous observational data generated by such autonomous sensor networks overwhelms scientific users when they have to analyze the data. In order to provide a scalable and effective analysis environment, there is a need for storage and analytics that support high‐throughput data ingestion while preserving spatiotemporal and sensor‐specific characteristics. Also, the framework should enable modelers and scientists to run their analytics while coping with the fast and continuously evolving nature of the dataset. In this paper, we presentRadix+, a high‐throughput distributed data storage system for supporting scalable georeferencing, and interactive query‐based spatiotemporal analytics with trackable data integrity. We include empirical evaluations performed on a commodity machine cluster with up to 1 TB of data. Our benchmarks demonstrate subsecond latency for majority of our evaluated queries and improvement in data ingestion rate over systems such as Geomesa.
qSUB2: A novel QTL with positive epistasis with SUB1 locus enhances submergence tolerance in rice
Authors: Akintayo Oluyemi , Daniel Isaac , Afeez Shittu , Jolayemi Okanlawon , Semwal Vimal , Venuprasad Ramaiah
Published: February 2023

Climate change is expected to significantly increase submergence stress of lowland rice (Oryza sativa) production in Africa. There is a need to further improve the ability of SUB1 gene to tolerate submergence stress. Genetic control of submergence tolerance was studied in a moderately tolerant to submergence African rice landrace “TOS6454.” Three mapping populations with a total of 1182 lines were developed by crossing TOS6454 with three popular rice varieties of West Africa that are high‐yielding but submergence susceptible, that is, FARO44, FARO52, and FARO60. The screening for submergence was conducted at the Africa Rice Center (AfricaRice) station in Ibadan, Nigeria during 2016–2018. The three mapping populations were genotyped with single nucleotide polymorphic markers either on the Kompetitive allele specific PCR or the DArTseq platforms. Quantitative trait locus (QTL) analysis revealed five different QTLs on chromosomes 1, 2, 3, 4, and 9. The QTLs on chromosomes 2 (qSUB2) and 9 (qSUB9) had consistent large effects and the tolerance alleles were contributed by TOS6454. The QTL on chromosome 9 (qSUB9) had a large effect on submergence tolerance in all three mapping populations. This QTL had a highest logarithm of odds (LOD) score of 30.46 and explained as much as 27.7% phenotypic variation (R2), with an additive effect of up to 9.39. The QTL on chromosome 2 (qSUB2) had a highest LOD score of 10.78 and explained up to 10.8% R2 for this trait. Furthermore, qSUB2 had positive epistasis with qSUB9 which further increased submergence tolerance. A total of 57 lines carrying both qSUB2 and qSUB9 alleles were superior to all other lines in submergence tolerance. qSUB9 co‐segregated with ART5 a marker for the SUB1 gene; thus, it is suggested that qSUB9 is the same as the well‐known SUB1 gene. Pyramiding qSUB2 with the SUB1 gene locus is expected to further improve submergence tolerance in elite rice varieties.
A circular monopole antenna for bandwidth enhancement using cylinder slots with triple band notch characteristics
Authors: Y Venkata Lakshmaiah , Roy Bappadittya
Published: February 2023

This article introduces a super wideband along with three notch bands circular patch monopole antenna. The design structure is applicable for microwave and high‐speed wireless devices (2.19 to 25 GHz). In order to create a broad band, a ring dimension circular patch is used. To generate three notch bands, six symmetrical tiny cylinder stubs are introduced on the ground. These notch band frequencies can eliminate unwanted interference from various wireless frequencies, which mainly cover three notch bands: 5.5–7.3, 12.05–14.46, and 17.71–19.5 GHz. The steady radiation, super bandwidth, and stable gain properties expand when the ring patch and line feed are combined. It is excellent for many UWB applications because of its compact size (39 × 29 mm 2) and large bandwidth (166.97% fractional bandwidth). This model employs various size reduction and matching approaches to get a better response. The mechanisms of these structures are identified, and overall performance is compared with parametric analysis, tables, and figure.
Using PhyloSuite for molecular phylogeny and tree‐based analyses
Authors: Xiang Chuan‐Yu , Gao Fangluan , Jakovlić Ivan , Lei Hong‐Peng , Hu Ye , Zhang Hong , Zou Hong , Wang Gui‐Tang , Zhang Dong
Published: February 2023

Phylogenetic analysis has entered the genomics (multilocus) era. For less experienced researchers, conquering the large number of software programs required for a multilocus‐based phylogenetic reconstruction can be somewhat daunting and time‐consuming. PhyloSuite, a software with a user‐friendly GUI, was designed to make this process more accessible by integrating multiple software programs needed for multilocus and single‐gene phylogenies and further streamlining the whole process. In this protocol, we aim to explain how to conduct each step of the phylogenetic pipeline and tree‐based analyses in PhyloSuite. We also present a new version of PhyloSuite (v1.2.3), wherein we fixed some bugs, made some optimizations, and introduced some new functions, including a number of tree‐based analyses, such as signal‐to‐noise calculation, saturation analysis, spurious species identification, and etc. The step‐by‐step protocol includes background information (i.e., what the step does), reasons (i.e., why do the step), and operations (i.e., how to do it). This protocol will help researchers quick‐start their way through the multilocus phylogenetic analysis, especially those interested in conducting organelle‐based analyses.
Vocational rehabilitation counselor burnout profiles and mindfulness
Authors: Lu Junfei , Brickham Dana , Jaeger Brian J. , Lo Chu‐Ling
Published: February 2023

Burnout of vocational rehabilitation (VR) counselors can not only lead to decreased job satisfaction and turnover but also damage the quality of VR services provided to clients with disabilities. It is an ethical obligation for VR counselors to engage in self‐care practices to prevent burnout. The current study surveyed 147 VR counselors from two State VR agencies about their current level of burnout and mindfulness related facets. Based on the latent profile analysis, four unique counselor burnout profiles were identified. These were well‐adjusted‐counselor, type I preserving‐counselor, type II preserving‐counselor, and disconnected‐counselor. Moreover, the results of multivariate analysis of variance tests disclosed that VR counselors with different counselor burnout profiles varied significantly on the mindfulness measure, especially in the facets of acting with awareness and non‐judging. The results have unique research and practice implications for the prevention and treatment of burnout of VR counselors.
Community‐level socioeconomic distress is associated with nutritional status in adults with sickle cell anemia
Authors: Ally Syeda Akila , Han Jin , Sun Ryan , Molokie Robert E. , Gordeuk Victor R. , Lash James P. , Saraf Santosh L.
Published: February 2023

Sickle cell anemia (SCA) negatively impacts the ability to achieve educational and occupational goals increasing vulnerability to socioeconomic challenges. In a cross‐sectional analysis of 332 SCA adults, we investigated whether the distressed community index (DCI) was associated with SCA‐related complications and nutritional status. More patients with higher DCI had Medicaid insurance. A higher DCI was independently associated with tobacco use and lower body mass index, serum albumin, and vitamin D 25‐OH levels after adjusting for insurance status but was not associated with SCA‐related complications. Future studies investigating access to healthy foods may help improve health equity in patients with SCA.