bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics, comorbidities, and complications in multiple sclerosis (MS) and non-MS patients undergoing lumbar fusion for deformity
Authors: Sulovari Aron , Kurucan Etka , Bernstein David Nathan , Mesfin Addisu
Published: July 2023

Background:

We compared the characteristics, comorbidities, and complications in spinal deformity patients with and without multiple sclerosis (MS) undergoing primary lumbar spine fusion.

Methods:

We used the Nationwide Inpatient Sample (NIS) from 2003 to 2014, International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis and procedure codes to create experimental MS (842 patients) and non-MS control (165,726 patients) cohorts undergoing primary lumbar spine fusion. Characteristics, comorbidities, and complications in spinal deformity patients with and without MS were evaluated using univariate and bivariate analysis.

Results:

MS spinal deformity patients undergoing primary lumbar spine fusion were younger, more likely to be female and more likely to undergo surgery at urban teaching hospitals. They also exhibited higher rates of depression and lower rates of diabetes without chronic complications, hypertension, and renal failure. However, no significant differences were found in mortality or total perioperative complication rates between MS and nonMS patients.

Conclusion:

We found that MS versus non-MS patients undergoing primary lumbar fusion for spinal deformity were younger, more likely to be female and had higher rates of depression but lower rates of diabetes, hypertension, and renal failure. Notably, both groups experienced comparable mortality and perioperative complication rates.
Concurrent Engineering Software Tools – A Trade-Off for efficient Learning in Blended Teaching Scenarios
Authors: Bach Christian , Drobny Christian , Tajmar Martin
Published: July 2023

Concurrent engineering is an approach to the development of complex systems that is characterised by direct communication between the disciplines involved. Key to this approach is the access to the most current design data by all participants at all times. This can be done via a dedicated software solution, for which both commercial and open-source software tools are available. How these tools influence the outcome of the class itself, has been discussed extensively in a separate publication.
This contribution presents the experience that we gathered with different concurrent engineering software tools. The aim of this contribution is to offer other teachers and students some guideline for selecting a concurrent engineering software solution and implementing it in course work, in a way that using the tool itself does not become the central learning challenge of the course. The results might be of interest beyond university courses, as some requirements, like short times to get familiar with the software or certain interface requirements, also apply to other environments in research and development.
Podcasting in der und für die Lehre
Authors: Lasch Alexander
Published: July 2023

Der Artikel versteht sich als ein Werkstattbericht, in dem über Erfahrungen aus der akademischen Lehre berichtet wird. Im Mittelpunkt stehen Möglichkeiten der niederschwelligen Podcast-produktion und des -hostings, sowie deren die Einbindung in die Lehre. Dazu werden drei Podcasts mit unterschiedlichen Zielen und Adressat:innenkreisen vorgestellt, um zu illustrieren, wie diese medial spezifischen Formate miteinander vernetzt sind und sich als eine mögliche Form der Dissemination zur Wissenschaftskommunikation und im Kontext von Citizen Sciences fruchtbar machen lassen.
Leveraging Bismuth Immiscibility to Create Highly Concave Noble Metal Nanoparticles
Authors: King Melissa , Xu Yuting , Mason Noah , Nagarajan Porvajja , Che Fanglin , Ross Michael
Published: July 2023

Noble metal nanoparticles can be designed to expose low- and high-index facets, providing precise control over the coordination environment of surface atoms. This control is essential for manipulating physical properties where surface adsorption is important, namely, sensing and catalysis. The integration of metals with differences in structure and electronics, while important for manipulating catalytic activity, does not typically yield structures with well-defined morphologies in colloidal synthesis. To create structures with unusually undercoordinated surfaces, here we leverage the immiscibility of incongruent crystal structures —Au and Bi — to synthesize and stabilize three distinct morphologies: concave tetrahedra, stella octangula (dual tetrahedron), and concave stella octangula. Structural and compositional analysis shows that only ~ 6 x10 -6 moles of surface Bi are needed to manipulate this morphology. Moreover, we show the generalizability of this methodology by synthesizing Pd concave tetrahedra with Bi-enriched surfaces. Electrocatalytic experiments reveal that these Au architectures are highly active toward alcohol oxidation, where surface Bi is critical for alcohol adsorption. Thus, integration of immiscible elements provides a new strategy for designing highly active nanoparticles with precision.
Unveiling the Configurational Landscape of Carbamate: Paving the Way for Designing Functional Sequence-Defined Polymers
Authors: Perez Mellor Ariel F. , Brazard Johanna , Kozub Sara , Bürgi Thomas , Szweda Roza , Adachi Takuji B. M.
Published: July 2023

Carbamate is an emerging class of polymer backbone for constructing sequence-defined, abiotic polymers. It is expected that new functional materials can be de novo designed by controlling the primary polycarbamate sequence. While amino acids have been actively studied as building blocks for protein folding and peptide self-assembly, carbamates have not been widely investigated from this perspective. Here we combined infrared (IR), vibrational circular dichroism (VCD) and nuclear magnetic resonance (NMR) spectroscopy with density functional theory (DFT) calculations to understand the conformation of carbamate monomer units in a non-polar, aprotic environment (chloroform). Compared with amino acid building blocks, carbamates are more rigid, presumably due to the extended delocalization of π-electrons on the backbones. cis configurations can be energetically stable for carbamates while peptides typically assume trans configurations at low energies. This study lays an essential foundation for future developments of carbamate-based sequence-defined polymer material design.
Comparative characteristics of reproductive function in mentally healthy and mentally ill women with infertility
Authors: Tyuvina Nina A. , Nikolayevskaya Angelina O. , Balabanova Vera V. , Ilchenko Kaleriia N.
Published: July 2023

Background. Issues of the relationship and interaction of menstrual and reproductive function and the mental state of women are not sufficiently studied and need additional research.
Aim. To conduct a comparative assessment of individual indicators of reproductive function in mentally healthy and mentally ill women with infertility.
Materials and methods. Of the 348 women with primary and secondary infertility aged 21 to 40 included in the study, 120 had been treated for a psychiatric disorder in a psychiatric hospital before this study. Patients were clinically evaluated using a specially designed questionnaire card and subsequent statistical processing of the results obtained.
Results. The menstrual-generative function of patients in the study groups significantly differed in several indicators. Mentally ill women with primary infertility were characterized by a later age of menarche, menstruation irregularity or absence during the disease exacerbation, scanty menstruations or heavy menstrual bleeding, inadequate emotional response to menarche, and irregularity and dissatisfaction with sexual life. Spontaneous miscarriages and stillbirths were more common in mentally ill women, especially those with endogenous diseases (schizophrenia, affective disorders), and abortions and gynecological operations were more common in mentally healthy women. Predictors of infertility related to mental health were early onset and chronic course of mental disorder, severity and duration of the disease exacerbations, short and incomplete remissions, and personality changes or a defect (schizophrenic) due to mental illness.
Conclusion. Menstrual and reproductive functions of women depend on their mental state. In women with mental conditions, menstrual function disorders, along with psychopathological symptoms of diseases (a decrease in sexual vigor, communication, anesthesia of feelings), and decreased social and family adaptation, lead to reproductive function disorders. Improving a woman's mental state can contribute to the recovery of her reproductive function.
Neuroprotective effects of estetrol in combined oral contraceptives: A review
Authors: Orazov Mekan R. , Ermakov Vasily V. , Novginov Dmitrii S.
Published: July 2023

One of the most effective contraception methods is combined hormonal contraceptives. According to the current prescribing information, in addition to their primary effect, they have several concomitant positive effects on the female body non-contraceptive effects. These include a well-predictable and controlled "menstrual cycle" (menstrual-like reaction), anti-androgenic effect, anti-anemic effect due to reduced menstrual blood loss, reducing the severity of dysmenorrhea and premenstrual syndrome, reducing the risk of pelvic inflammatory diseases, ectopic pregnancy, and some benign and malignant tumors of the reproductive system. Combined oral contraceptives (COCs) also have effects on the central nervous system, hypothalamic-pituitary structures that regulate sex hormones, and the psycho-emotional health of women. For a long time, the main estrogen component of COCs remained ethinylestradiol. Although not well-studied, its mechanisms of action on the nervous system are similar, regardless of the progestogen component. However, the effect was not entirely positive: taking contraceptives containing ethinylestradiol can lead to increased emotional lability, anxiety, and depressive disorders. It drives researchers to search for new estrogen without these adverse properties. Such is the long-known but overlooked esthetrol. Numerous studies indicate a pronounced neuroprotective effect of esthetrol, which can increase patients' satisfaction with hormonal contraceptives and their compliance. It also opens up great opportunities for the use of this drug beyond gynecological practice.
The effect of fetal alcohol syndrome on the mental and physical development of a preschool child: a clinical case
Authors: Marianian Anait Yu. , Molchanova Elena V. , Molchanova Anastasia M.
Published: July 2023

The article describes a clinical case demonstrating the effect of fetal alcohol syndrome on a preschool child's development, demonstrating the challenging diagnosis of this disorder, often leading to irreversible congenital mental and physical defects. The challenging diagnosis is because doctors are unaware of the mother's alcohol consumption during pregnancy. Doctors may suspect that the child has Fetal alcohol syndrome, according to the presence of facial dysmorphism and the state of health of the mother (pronounced signs of alcohol dependence). The clinical manifestations of the adverse effects of alcohol on the development of the child described in the article indicate the need to organize early diagnosis and comprehensive habilitation.
Endothelial dysfunction in the mother–placenta–fetus system after a new coronavirus infection SARS-CoV-2: An open prospective cross-sectional study
Authors: Medyannikova Irina V. , Kuklis Yuliya Ch. , Saveljeva Irina V. , Beznoshchenko Galina B. , Galyanskaya Elena G. , Tsygankova Olga Yu. , Prodanchuk Evgeny G. , Bukharova Elena A. , Nosova Natalya V. , Davidov Pavel V.
Published: July 2023

Background. Generalized endotheliopathy in SARS-CoV-2 is associated with the release of the vasoactive peptide endothelin-1, which stimulates the activation of both the plasma and platelet clotting pathways. It is believed that endothelin-1 is one of the most potent vasopressors of the human cardiovascular system and has a strong pressor and thrombogenic effect on many vessels, including in the motherplacentafetus system.
Aim. To study endothelial dysfunction in pregnant women with new coronavirus infection SARS-CoV-2.
Materials and methods. An open-label prospective continuous cross-sectional study enrolled 96 patients who survived COVID-19 at various gestational ages. Depending on the severity of the underlying disease, patients were divided into groups: Group 1 (n=18) included patients with mild SARS-CoV-2 coronavirus infection, Group 2 (n=56) included women with moderate severity, Group 3 (n=22) included patients with severe COVID-19. The control group consisted of 100 pregnant women who had no COVID-19 or signs of acute respiratory viral infection. In all groups, endothelin-1 levels were determined by enzyme-linked immunosorbent assay.
Results. In pregnant women with no COVID-19 and patients after mild COVID-19, the level of endothelin-1 corresponds to the reference values; in pregnant women with moderate and severe underlying disease, the level of endothelin-1 was 2.04.0 pmol/L. It reflects the increased activity of the endothelium in the uterine bloodstream and blood vessels in the motherplacentafetus system. Placental insufficiency in women after COVID-19 is caused by endothelial dysfunction that triggers vasospasm and increased vascular resistance in the uterine arteries (r=0.8; p0.01).
Conclusion. The diagnosis of endothelial dysfunction in the motherplacentafetus system after COVID-19 can be helpful in the prediction and prevention of vascular complications, both placental, associated with great obstetrical syndromes (premature birth, intrauterine growth retardation, preeclampsia, antenatal fetal death), and extraplacental ones (arterial and venous thrombosis).
Current approaches in the diagnosis, treatment and prevention of HPV-associated cervical diseases: practical recommendations. A review
Authors: Prilepskaya Vera N. , Iurova Mariia V.
Published: July 2023

Papillomavirus infection is one of the most important infectious diseases of the reproductive system. The genome of human papillomavirus (HPV) transforms the cervical epithelial cells, leading to progressive changes: from cervical epithelial neoplasia to carcinoma in situ and further to invasive cancer. More than 550 000 cases of cervical cancer (CC) are reported yearly. In Russia, the incidence of CC in 2020 decreased for the first time in 20 years, and the average annual rate of increase in incidence was 1.27%. It became possible thanks to the introduction of a new system of diagnosis, treatment, and prevention of cervical cancer, in particular, the introduction of screening and a program of modern methods of diagnosis and treatment. Uniform for all countries, screening cervical diseases aims to diagnose changes in the cervical epithelium that occur due to HPV, which may be silent. Until now, the basis of screening programs was a cytological study (pap-test). Since 2018, most EU countries have switched to primary screening for HPV (HPV test) due to its greater sensitivity compared to the cytological method. No etiopathogenetic methods of HPV therapy have been developed yet. However, numerous studies have described the effective treatment of HPV-associated cervical lesions. It was shown that the most effective is a comprehensive approach involving treatment aimed at abnormal tissues and nonspecific antiviral and immunomodulatory therapy. The basis of the CC prevention strategy, of course, is primary prevention through vaccination. Studies are ongoing on the effectiveness of the new generation of vaccines based on the L2 viral protein and therapeutic vaccines against HPV.
Current methods of normalization and maintenance of mucous membranes in gynecology: A prospective study
Authors: Sotnikova Larisa S.
Published: July 2023

Background. The study of the recovery and restoration of the mucous membranes of the genital tract with vaginal intimate gels is presented.
Aim. To determine the clinical effectiveness of special cosmetic gels for intimate hygiene, Floragel and Vagizhenal for restoration of the mucous membranes of the vulva and vagina.
Materials and methods. Two groups of women were formed, Floragel and Vagizhenal, to analyze the clinical efficacy of cosmetic gels for intimate hygiene. Group 1 included 30 women aged 25 to 55 with clinical symptoms of genital tract mucosa atrophic changes and the absence of normal vaginal microflora. For intimate hygiene, this group regularly used the gel for intimate hygiene Floragel for 1 month. Group 2 included 30 women aged 25 to 55 with clinical symptoms of genital tract mucosa atrophic changes of various etiologies. For intimate hygiene, this group regularly used the gel for intimate hygiene Vagizhenal for 1 month. The gels were applied regularly, two times a day in the morning and evening, in a thin layer after hygienic procedures. Evaluation of the clinical effectiveness of special cosmetic gels for intimate hygiene Floragel and Vagizhenal included assessment of clinical efficacy, indicators of gynecological status, findings of microscopic and microbiological examination of vaginal discharge (Femoflor system), determination of the vaginal health index, and measurement of nonspecific immune protection of the vagina levels of interferon , interleukin (IL)-1, IL-6, IL-10 in the vaginal discharge using enzyme-linked immunosorbent assay.
Results. As shown by the questionnaires and interviews with patients, the use of special cosmetic gels for intimate hygiene, Floragel and Vagizhenal was associated with a significant improvement (p0.05) in clinical symptoms: an improvement of vaginal discharge, the disappearance of unpleasant odor and itching, and an improvement in the state of the vaginal mucous membranes and vulva. A special gynecological examination showed significant changes in the visual morphological and functional state characteristics of the vaginal mucosa and vulva. An improvement was reported in 90% (27) patients (p0.05) who used Floragel and in 80% (24) patients who used Vagizhenal.
Conclusion. The results demonstrate Floragel and Vagizhenal gels' high efficiency in restoring normal microflora and moisturizing mucous membranes by optimizing microbiological indicators, improving the vaginal health index and local immunity factors, indicating that special gels for intimate hygiene Floragel and Vagizhenal have not only cosmetic but also therapeutic properties.
Efficacy and safety of non-hormonal agents for vasomotor symptoms of menopause: A prospective, double-blind, placebo-controlled study
Authors: Radzinsky Viktor E. , Orazov Mekan R. , Khamoshina Marina B. , Orekhov Roman E. , Zhuravleva Irina S.
Published: July 2023

Aim. To assess the safety and efficacy of non-hormonal agents for mild vasomotor symptoms of menopause.
Materials and methods. The study included 173 females aged 4855 with mild vasomotor symptoms during the early postmenopausal period. Patients in the study cohort were stratified into two groups by the double-blind method. In group 1 (study), the patients took the homeopathic agent Neoclimsal 1 tablet 4 times a day sublingually until completely dissolved for 4 weeks (n=86). In group 2 (n=87), the patient received a placebo (30 mg of microcrystalline cellulose) in a regimen mimicking the study treatment. Twenty-three patients withdrew from the study due to protocol violation or revoked their consents for reasons not related to medication. At the end of the study, 75 patients remained in both groups. The therapeutic efficacy was assessed based on the Greene and MENQOL scores change. The SF-36 questionnaire was used to evaluate patients' quality of life, and the average rate of falling asleep was calculated to assess the change in sleep disturbance. The change of M-echo and mammography results were reviewed using the BI-RADS scale 12 months after the start of the treatment to assess the agent's safety. Study design: A prospective, double-blind, placebo-controlled study.
Results. The course of Neoclimsal, sublingual tablets, reduced the severity of vasomotor symptoms by 2.3 times, the severity of depression by half (p0.001), and at the end of treatment after 12 weeks of observation, the therapeutic effect not only persisted but tended to increase (p0.001). Improvement in the quality of life of patients treated with Neoclimsal was confirmed by an improvement in the MENQOL score by 1.4 times a month after the start of therapy while maintaining the achieved result after 12 weeks of observation (p0.001). The drug's safety is confirmed by the absence of adverse side effects and allergic reactions, the absence of endometrial thickness change within 3 months after the start of treatment, and mammography results using the BI-RADS scale at 12 months.
Conclusion. The results indicate the effectiveness of non-hormonal therapy in relieving vasomotor symptoms of mild postmenopause with a high safety profile. The drug has a beneficial effect on sleep disorders, reducing the severity of mental distress and improving the general quality of life.
Acetylsalicylic acid as the only pharmacological method for the prevention of preeclampsia: A retrospective study
Authors: Kravtsova Olga M. , Kuznetsov Pavel A. , Dzhokhadze Lela S. , Dobrokhotova Yulia E. , Zatevalov Aleksandr M.
Published: July 2023

Background. Preeclampsia (PE) complicates 28% of pregnancies worldwide, negatively impacting the pregnant woman and the fetus. Therefore, its prevention remains relevant. It is believed that the cause of PE, especially early PE, is a placentation disorder. It warrants studying drugs that can improve placenta development. The leadership in this matter is maintained by acetylsalicylic acid, which, according to the ASPRE study, reduced the incidence of PE at 34 weeks of pregnancy by 82%. The use of low molecular weight heparins (LMWH), dipyridamole, and antioxidants for PE prevention remains controversial and continues to be studied by foreign and Russian scientists.
Aim. To assess the efficacy of acetylsalicylic acid, LMWH, dipyridamole (Curantyl), and bovine blood derivates (Actovegin) in the Russian population of pregnant women at high risk for PE prevention.
Materials and methods. The study included 244 patients. We reviewed the archived case records of 103 patients diagnosed with severe PE, who delivered in 2019 at the State Clinical Hospital №24, and 141 pregnant women from the Maternity clinic №3 at the Veresaev Moscow State Clinical Hospital, where the risk of PE was assessed as high, according to the results of extended combined screening of the first trimester of pregnancy. Eighty-nine pregnant women received acetylsalicylic acid at a dose of 75 mg and 54 at a dose of 150 mg. In addition, 22 patients received LMWH, 6 dipyridamole, and 3 Actovegin. The absolute risks, the risk ratio, and statistical significance when taking drugs in each risk group were calculated to assess the efficacy of acetylsalicylic acid and other drugs for PE prevention in the above risk groups.
Results. The resulting weak inverse correlation (r=-0.31) between the PE severity at delivery and the dose of acetylsalicylic acid indicates that an increase in the acetylsalicylic acid dose was associated with a decrease in the PE severity. The effectiveness of combinations of various drugs for PE prevention was assessed by analyzing factor correspondences. Two-dimensional scaling of the most likely combinations showed that most patients received acetylsalicylic acid in the high-risk group with no PE. Additional use of LMWH, Curantyl, and Actovegin did not reduce the risk of PE.
Conclusion. Acetylsalicylic acid is the only pharmaceutical method for preventing PE in high-risk groups. Higher doses of acetylsalicylic acid are associated with lower PE severity.
Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study
Authors: Rybnikov Sergey V. , Artymuk Natalia V.
Published: July 2023

Aim. To evaluate the effectiveness of hyaluronic acid anti-adhesion gel in surgical correction of distal tubal occlusion in restoring natural fertility in patients with infertility.
Materials and methods. A prospective cohort study was conducted. The main group (group 1) included 54 women; the comparison group (group 2) included 58 women with tuboperitoneal infertility due to distal occlusion of the fallopian tubes. In group 1 patients, at the final stage of endoscopic reconstructive plastic surgery on the surface of the fallopian tubes, anti-adhesion barrier Anti-adhesion was applied (5 mL per each operated fallopian tube). Primary outcomes (patency of the fallopian tubes after 3 months) and secondary outcomes (onset of uterine pregnancy during the first year) were assessed. Statistical results were processed using the IBM SPSS Statistics version 25.0 software package.
Results. Within 3 months after surgical treatment, the patency of the fallopian tubes was reported in 32 (59.3%) group 1 patients and 24 (41.4%) group 2 patients (2=3.445; p=0.064). The rate of uterine pregnancy in group 1 during the first year after surgical treatment was significantly higher than in group 2: 21 (38.9%) and 12 (20.7%) women, respectively (2=4.447; p=0.035).
Conclusion. Endoscopic reconstructive plastic surgeries using hyaluronic acid-based anti-adhesion gel in patients with distal tubal occlusion slightly reduces the frequency of postoperative reocclusions of the fallopian tubes within 3 months after surgical treatment and significantly increase the rate of uterine pregnancy during the year after surgery mainly due to patients with grade IIIIV of adhesive process in the pelvis.
Secnidazol`s effectiveness for the bacterial vaginosis treatment
Authors: Serova Olga F. , Shmeleva Galina M. , Shutikova Natalia V.
Published: July 2023

Background. Bacterial vaginosis is an infectious non-inflammatory syndrome with polymicrobial etiology associated with dysbiosis of the vaginal biotope.
Aim. To assess the clinical efficacy and safety of Secnidox in treating bacterial vaginosis in women 2059 years.
Materials and methods. The study included 30 patients (mean age 31.14.7 years) with bacterial vaginosis who received 2 g of secnidazole (Secnidox) as a single dose. All patients were followed up by an obstetrician-gynecologist at two visits.
Results. Secnidazole provided sanitation of the vagina. Normalization of clinical symptoms and laboratory tests was reported.
Conclusion. Secnidazole showed good therapeutic efficacy and normalization of the vaginal microflora.
LOBACHEVSKY GEOMETRY – THE FIRST NON-CLASSICAL SCIENTIFIC THEORY
Authors: Коськов С.Н.
Published: July 2023

Обычно появление неклассической науки относят к началу XX в. Прежде всего имеют в виду теорию относительности, квантовую механику, излучение энергии, генетику, что совершенно справедливо. Но автор подчеркивает, что первая неклассическая теория появилась уже в первой половине XIX в. в области математики. По своим методологическим и мировоззренческим основаниям именно геометрия Лобачевского стала первой неклассической теорией.

Usually, the appearance of non-classical science is generally attributed to the beginning of the 20th century. First of all, they mean the theory of relativity, quantum mechanics, energy radiation, genetics, which is absolutely true. But I consider it necessary to emphasize that the first non-classical theory appeared already in the first half of the 10th century in the field of mathematics. According to its methodological and ideological foundations, it was Euclid's geometry that became the first non-classical theory.
GLOBAL SOCIO-ECONOMIC DEVELOPMENT: GENERAL PATTERNS AND PROSPECTS
Authors: Шорохов Ю.И.
Published: July 2023

В статье изложены результаты очередного этапа исследований проблем глобального социально-экономического развития. В ее основу положена предложенная автором концепция глобального развития как поэтапного роста пирамиды жизни в соответствии с ключевым направлением эволюции. Цель статьи заключается в выявлении фундаментальных свойств и условий поступательного роста этой пирамиды. Научная новизна: показано, что пирамида жизни представляет собой фрактальное множество социальных организмов; рост пирамиды жизни сопровождается радикальным расширением объема доступных знаний и таким же ростом созидательного и разрушительного потенциала. В современных условиях традиционная, конфронтационная модель глобального развития ведет к конфликтам, войнам, распаду пирамиды и откату человечества на предыдущий, возможно доисторический, этап развития. Дальнейшее развитие в соответствии с ключевым направлением эволюции требует радикального изменения системы ценностей и перехода на консолидационную модель развития.

The article presents the results of the next stage of research on the problems of global socio-economic development. It is based on the concept of global development proposed by the author as a gradual growth of the pyramid of life in accordance with the key direction of evolution. The purpose of the article is to identify the fundamental properties and conditions for the progressive growth of this pyramid. Scientific novelty: it is shown that the pyramid of life is a fractal set of social organisms; the growth of the pyramid of life is accompanied by a radical expansion of the amount of available knowledge and the same growth of creative and destructive potential. In modern conditions, the traditional, confrontational model of global development leads to conflicts, wars, the collapse of the pyramid and the rollback of humanity to the previous, possibly prehistoric, stage of development. Further development in accordance with the key direction of evolution requires a radical change in the value system and the transition to a consolidation model of development.
RUSSIA IN THE GLOBAL MODERNIZATION PROCESSES
Authors: Канарш Г.Ю.
Published: July 2023

В статье отстаивается точка зрения, что Россия, несмотря на переживаемые ею в настоящий момент трудности, не должна изолироваться от остального мира, а ей следует внимательно следить за теми социокультурными и технологическими изменениями, которые происходят сегодня в развитых и развивающихся странах. Как показано в статье, это, прежде всего, ценностные изменения, ведущие к трансформации различных сфер жизни и формированию общества искусственного интеллекта. В то же время Россия до сих пор стоит перед выбором своей модели социально-экономического развития. Как показывают исследования, сырьевая модель на настоящий момент исчерпала себя, а производственная до сих пор не построена. Существуют значительные трудности в плане реализации производственной модели в России по образцу многих развитых и развивающихся стран Восточной и Юго-Восточной Азии. Сохраняется и проблема, какой путь (социалистический, капиталистический) наиболее предпочтителен в рамках производственной модели. В целом, делается вывод о том, что без свободного рынка и капитализма нет развития, однако достаточно весомой в мире продолжает оставаться роль государства.

The article defends the point of view that Russia, despite the difficulties it is currently experiencing, should not be isolated from the rest of the world and should closely monitor the socio-cultural and technological changes that are taking place today in developed and developing countries. As shown in the article, these are, first of all, value changes leading to the transformation of various spheres of life and the formation of an «artificial intelligence society». At the same time, Russia is still facing the choice of its model of socio-economic development. Research shows that the raw material model has exhausted itself at the moment, and the production model has not yet been built. There are significant difficulties in terms of implementing a production model in Russia, modeled on many developed and developing countries in East and Southeast Asia. There is also the problem of which path (socialist, capitalist) is most preferable within the framework of the production model. In general, it is concluded that there is no development without a free market and capitalism, but the role of the state continues to be quite significant in the world.
MAIN DIRECTIONS OF STRENGTHENING OF DEFENCE AND NATIONAL SECURITY OF THE REPUBLIC OF BELARUS
Authors: Ксенофонтов В.А.
Published: July 2023

Показаны современные тенденции развития международной и военнополитической обстановки, ведущие к усилению военного противоборства. Конфликтная среда и указанные негативные факторы существенно влияют на обеспечение национальной безопасности Беларуси. В условиях усиления военного насилия военная сфера национальной безопасности становится важнейшим приоритетом в системе государственного управления. Показаны основные внутренние и внешние источники угроз в военной сфере. Акцентируется внимание на изменении содержания войны. Рассмотрена особенность коалиционной военной составляющей национальной безопасности Беларуси в контексте развития Союзного государства. Сделан вывод о путях совершенствования военной сферы национальной безопасности как важнейшем условии сохранения государства. Необходимо дальнейшее развитие научной и информационно-аналитической составляющей в рамках направления «Философия безопасности».

The article reveals current trends in the international and military-political situation, leading to strengthening of military confrontation. The conflict environment and the specified negative factors have a significant impact on the national security of Belarus. Under growing military violence the military sphere of national security becomes the most important priority in the system of state administration. The main internal and external sources of threats in the military sphere are shown. Attention is paid to the changing content of the war. The peculiarities of the coalition military component of the national security of Belarus in the context of the Union State development are considered. A conclusion is made about the ways to improve the military sphere of national security as a major condition for the preservation of the state. It is necessary to further develop the scientific and information-analytical constituent within the framework of the «Philosophy of security».
INVERSIVE SEMIOTICS OF THE IMAGE OF GRIGORY RASPUTIN
Authors: Лебедев В.Ю. , Прилуцкий А.М.
Published: July 2023

В статье анализируется при помощи методов инверсивносемиотического анализа специфика религиозного почитания Григория Распутина. Авторы доказывают, что популярность культа Распутина в фундаменталистских православных субкультурах обусловлена инверсивным скандалом. В основе этого скандала изначально было несоответствие низкого социального статуса Распутина в контексте российского сословного общества и его приближенности к семье императора, которая интерпретируется как участие в управлении государством. В современных условиях данный конфликт осложнился особым статусом Николая Второго в агиологии маргинального православия. Данный конфликт разрешается через семиотическую дискредитацию противников культа Распутина и через его канонизацию в маргинальных микроскопических православных юрисдикциях.

The article analyzes the specifics of the religious veneration of Gregory Rasputin using the methods of inversion and semiotic analysis. The authors argue that the popularity of the Rasputin cult in fundamentalist Orthodox subcultures is due to an inversion scandal. At the heart of this scandal was the discrepancy between Rasputin's low social status in the context of the Russian class society and his closeness to the emperor's family, which is interpreted as participation in government. In modern conditions, this conflict was complicated by the special status of Nicholas II in the hagiology of marginal Orthodoxy. This conflict is resolved through the semiotic discrediting of the opponents of the Rasputin cult and through his canonization in marginal microscopic Orthodox jurisdictions.
WATER AND PEACE. WAS THALES NAIVE?
Authors: Матвейчев О.А.
Published: July 2023

Знаменитый тезис Фалеса о том, что всѐ есть вода, известен нам через Аристотеля, давшему ему интерпретацию, благодаря которой Милетец предстал перед потомками довольно простодушным мыслителем. Автор настаивает, что восстановление интенций ранних греческих философов возможно лишь при условии вынесения за скобки вульгарных трактовок их наследия, исходящих из априорной установки на примитивизм греков. Фалес, рассуждающий о воде как первоэлементе, имеет в виду не эмпирическую воду. Известная нам вода есть отражение воды сущностной, как «фюсис» всего сущего – внутреннего закона, внутреннего роста, механизма появления и развертывания вещи. Вода в учении Фалеса концептуально связана с целой системой верований, примет, сказаний, укорененных в древней индоевропейской традиции, носители которой использовали те же метафоры (за неимением разработанной философской терминологии) для объяснения природных закономерностей.

The famous theory of Thales stating that everything in the world derives from water is known to us through Aristotle, who gave it an interpretation, due to which Miletus appeared to posterity as a rather simple-minded thinker. The author insists that the restoration of the early Greek philosophers’ intentions is possible only if their heritage vulgar interpretations, based on an a priori attitude towards the primitivism of the Greeks, are put aside. While speaking about water as a primary element, Thales does not refer to empirical water. The water, as we know it, reflects the essential water, as the physis of everything existing – the internal law, the internal growth, the mechanism for the appearance and deployment of a thing. In the teachings of Thales water is conceptually connected with a whole system of beliefs, signs, and legends, rooted in the ancient Indo-European tradition, whose carriers used the same metaphors (due to the lack of developed philosophical terminology) to explain natural patterns.
MEDIEVAL PHILOSOPHY AS A STAGE IN THE DEVELOPMENT OF THE WORLD SPIRIT IN HEGEL'S SYSTEM
Authors: Марчукова Е.С.
Published: July 2023

Статья посвящена анализу специфики средневековой философии через призму гегелевской системы философии как науки. Эпоха Средневековья в таком контексте представлена как историческая среда, порождающая определенную форму выражения философского содержания. В статье проанализированы рассуждения Гегеля непосредственно об эпохе Средневековья и о средневековой философии, в частности, изложенные в его «Лекциях по истории философии». Особое внимание уделено прояснению ключевого для гегелевской системы понятия дух (Geist). Автор приходит к выводу, что в контексте гегелевской системы средневековая философия является необходимым этапом развития абсолютного духа, открывая для него возможность перехода к Новому времени.

The article analyses the specificity of medieval philosophy through the prism of Hegel's system of philosophy as a science. The Middle Ages era in this context is presented as a historical milieu generating a certain form of philosophical content expression. The article analyses Hegel's discourse directly on the Middle Ages and on medieval philosophy, in particular, as set out in his «Lectures on the History of Philosophy». Particular attention is paid to clarifying the key concept of spirit (Geist) in Hegel's system. The author concludes that in the context of Hegel's system medieval philosophy is a necessary stage in the development of the absolute spirit, opening for it the possibility of transition to the Modern Age.
Avaliação neuromotora de cães com afecções da coluna vertebral submetidos ao tratamento com acupuntura e moxabustão
Authors: Lima Jane Glayce Pereira , Linden Lais Alburquerque van der , Santos Renan Felipe Silva , Oliveira Rhaysa Allayde Silva , Costa Fabiano Sellos , Brito Jacinta Leite , Lima Helvio Rodrigues de , Lima Evilda Rodrigues
Published: July 2023

Objetivando-se avaliar os aspectos neurológicos de cães com afecções na coluna vertebral, este estudo utilizou 14 animais adultos, de diferentes raças e ambos os sexos. Após os diagnósticos através de uma minuciosa avaliação clínica e da realização de exame radiográfico e tomografia computadorizada, foram submetidos ao tratamento da acupuntura e da moxabustão durante 120 dias, uma vez por semana, por 30 minutos, totalizando 20 sessões. Os pontos trabalhados foram: B23, B40, B60, VB20, VB30, VB34, VG1, VG2, VG 20, E36, R3, IG4; e os pontos extras foram: Jiang Jia ji, Hua Tuo Jia Ji e Wei Jian. Na primeira avaliação foi observada dor à palpação da coluna vertebral em todos os animais, sendo alguns com hirperestesia. Após a segunda sessão, os animais não manifestaram reação à dor. Dos 14 animais submetidos ao tratamento com acupuntura associada à moxabustão, 11 apresentaram progressão funcional total, com demonstração do retorno da marcha sem quedas e sem auxílio; dois apresentaram progressão parcial, quando retornaram a caminhar sem auxílio, porém com ataxia e quedas esporádicas; um com progressão funcional insatisfatória, com sinais neurológicos iniciais inalterados. A associação da técnica agulhamento e moxabustão foi eficaz para os quadros de dor e na reabilitação motora de cães com diferentes afecções neurológicas.
Use of grayscale histogram to assess testicular changes in ram caused by heat stress
Authors: Veloso Neto Humberto Fernandes , Chaves Maiana Silva , Ferreira-Silva José Carlos , Vieira Joane Isis Travassos , Araujo Rosane Jamille de Oliveira , Santos Filho José Pompeu dos , Silva Filho Manoel Lopes da , Freitas Vicente José de Figueiredo , Oliveira Marcos Antonio Lemos
Published: July 2023

Because it detects discrete changes in tissue density, ultrasound allows an early diagnosis of physiologic changes, especially when dealing with subclinical changes. aimed to evaluate the use of quantitative analysis of the gray scale of ultrasound images of ovine testicles as a method for early diagnosis of testicular changes caused by heat stress. Testicles from ten ovine were insulated and then evaluated regarding echogenicity, echotexture, anatomical measurements, and seminal characteristics. Echogenicity was the first variable to show changes during the insulation period, as well as the first one to show evidence of regeneration of those changes. There was a correlation (p < 0.05) between echogenicity and sperm vigor, motility, and mass sperm motility, as well as a correlation (p < 0.05) between echotexture and motility. Echogenicity, motility, vigor, and mass sperm motility decreased (p < 0.05) within four days of testicular insulation, and there was no change (p > 0.05) in echotexture. Testicular measurements were only altered (p < 0.05) after insulation; however, the structural integrity of the seminiferous tubules was not altered. Echogenicity is an efficient ultrasound parameter for the early diagnosis of a testicular degenerative process as well as for the early diagnosis of its regeneration.
Ultrassonografia na confirmação de deslocamento de abomaso à esquerda em vaca leiteira: relato de caso
Authors: Carvalho André Luis Mendes Azevedo , Nascimento Neto José da Páscoa , Rezende Luana Carla , Rodrigues Luísa Holanda Andrade , Sant’Ana Ana Carolina Chalfun de , Chalfun Luthesco Haddad Lima
Published: July 2023

O constante desenvolvimento da bovinocultura leiteira é acompanhado pela criação de animais com maior potencial genético e produtivo, necessitando de avanços relacionados ao manejo, nutrição, controle de doenças, dentre outros. Com isso, é de extrema importância o aperfeiçoamento de técnicas para exames de diagnóstico que possam ser empregados na rotina clínica à campo. Objetiva-se relatar um caso de diagnóstico de deslocamento de abomaso à esquerda em bovino, realizado por meio de avaliação ultrassonográfica trans-abdominal. A paciente apresentou sinais clínicos sugestivos desta enfermidade e presença de som metálico “ping” na auscultação. Foi realizado exame ultrassonográfico por meio de varredura dos últimos espaços intercostais do antímero esquerdo para confirmação da presença do abomaso em local atípico. O diagnóstico foi validado por laparotomia exploratória pelo flanco direito, seguida por esvaziamento e correção do abomaso para posição anatômica original. O animal retornou gradualmente a alimentação e produção de leite normais, apresentando-se clinicamente saudável. Portanto, a avaliação ultrassonográfica trans-abdominal foi capaz de confirmar o diagnóstico de deslocamento de abomaso e auxiliou para que a saúde e bem-estar da paciente fossem reestabelecidos através do tratamento instituído. O diagnóstico por imagem apresenta elevado potencial para disseminação na clínica médica de bovinos, especialmente em atendimentos à campo.
Tromboembolismo em artéria femoral direita de um felino: análise dopplervelocimétrica
Authors: Marques Danielle Climaco , Rodrigues Renan Paraguassu de Sá , Leitão Kelvin Ramon da Silva , Silva Andrezza Braga Soares da , Sousa Francisco das Chagas Araújo , Alves Flávio Ribeiro
Published: July 2023

O tromboembolismo arterial é definido como a formação de um trombo na circulação sanguínea, que se desloca e provoca a obstrução do fluxo sanguíneo no interior de uma artéria. Essa obstrução pode causar lesões isquêmicas em diversos órgãos, de acordo com a sua localização. A artéria femoral é um dos principais vasos na perfusão dos membros pélvicos de felinos e trombos nessa região podem comprometer a função desse membro. O presente estudo teve como objetivo relatar a análise dos parâmetros Doppler de um felino com tromboembolismo em artéria femoral direita em estágio avançado e com indícios de isquemia. A ultrassonografia Doppler demonstrou um estreitamento do lúmen dos vasos e velocidade reduzida no interior da artéria femoral, sugerindo um quadro de tromboembolismo. A ultrassonografia Doppler foi um método eficaz na detecção e no prognóstico de tromboembolismo da artéria femoral de um felino.
Проєктування бази даних до гри «Minecraft»
Authors: Сугоняк Інна Іванівна , Коротун Ольга Володимирівна , Левицький Андрій Андрійович , Сугоняк Владислав Андрійович
Published: July 2023

Мета статті – виконати зворотну розробку (англ. reverse engineering) популярної гри Minecraft в аспектах взаємодії ігрових даних та їх зберігання для подальшого використання. На основі отриманих даних спроєктувати базу даних і текстову симуляцію названої вище гри для отримання навичок з формування структурованих систем даних для ігрових продуктів, які потребують складної взаємодії даних. У статті висвітлено основні алгоритми формування бази даних та взаємодії між даними так, як це вимагає тип ігрового продукту та його вміст. Продемонстровано чотири етапи розробки програмного продукту. На першому етапі сформовано концепт для проєктування бази даних, проаналізовано дані, які потрібно зберігати, та визначено ідею для створення інформаційної системи, як і використовувані засоби проєктування програмних продуктів та системи управління базами даних (СУБД). Другий етап описуватиме формування бази даних зі всіма особливостями, представленнями, процедурами та тригерами для комфортної обробки даних при проєктуванні програмного продукту, та використання бази даних в інформаційній системі, та роботу з нею при різних діях гравця. Третій – вигляд, структура та робота симуляцій гри у вигляді вебдодатка, особливості роботи такої платформи з базою даних та концепт ігрового процесу. Також на цьому етапі висвітлено готовий програмний продукт, який представляє роботу сформованої бази даних та симуляцію гри «Minecraft». В базі даних також важлива безпека доступу до даних, тому на четвертому етапі буде розглянуто реалізацію захисту бази даних. Для роботи з даними використано СУБД Microsoft SQL Server, створено симуляцію гри у вигляді сайту за допомогою мови програмування С#, платформи ASP.NET та фреймворку для роботи з базами даних Entity Framework.