bluuebunny/crossref_metadata_2025 huggingface dataset:
Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic Foot Ulcer Infections
Authors: Chijcheapaza-Flores Henry , Tabary Nicolas , Chai Feng , Maton Mickaël , Staelens Jean-Noel , Cazaux Frédéric , Neut Christel , Martel Bernard , Blanchemain Nicolas , Garcia-Fernandez Maria José
Published: March 2023

Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and antibiotic resistance. Hydrogels are now being used as a new treatment option since they can be used for drug delivery and to improve wound healing. This project aims to combine the properties of hydrogels based on chitosan (CHT) and the polymer of β cyclodextrin (PCD) for local delivery of cinnamaldehyde (CN) in diabetic foot ulcers. This work consisted of the development and characterisation of the hydrogel, the evaluation of the CN release kinetics and cell viability (on a MC3T3 pre-osteoblast cell line), and the evaluation of the antimicrobial and antibiofilm activity (S. aureus and P. aeruginosa). The results demonstrated the successful development of a cytocompatible (ISO 10993-5) injectable hydrogel with antibacterial (99.99% bacterial reduction) and antibiofilm activity. Furthermore, a partial active molecule release and an increase in hydrogel elasticity were observed in the presence of CN. This leads us to hypothesise that a reaction between CHT and CN (a Schiff base) can occur and that CN could act as a physical crosslinker, thus improving the viscoelastic properties of the hydrogel and limiting CN release.
Physical Properties of the Canary Islands’ Volcanic Pyroclastic Materials as Horticultural Substrates
Authors: Santos Coello Belarmino , Ríos Mesa Domingo
Published: March 2023

In the Canary Islands and in other parts of the world where it can be found in its natural state, basaltic tephra, or “Picón” as it is known locally, is commonly used as a soilless substrate for crops. The aim of this study is to learn more about the physical properties of the Canary Islands’ tuff, and to find a simple method to predict the hydraulic behaviour of these substrates due to their heterogeneity. To accomplish this, 32 tuff samples were collected from all the quarries on the island of Tenerife (Canary Islands) that were authorised for the study. The tuffs had hydraulic properties that were highly influenced by the particle size. Coarse tuffs had an aeration capacity greater than 35% v/v and easily available water of less than 5% (v/v), while fine tuffs had aeration capacities below 20% v/v and elevated water retention (20 to 26% v/v). The intermediate tuffs had characteristics that varied between those of the two previous groups. Particle size fractions of less than 1 mm demonstrated the best correlation to common air:water ratios and present the best predictive capacity to relations involving air. By focusing on air:water ratios and the previous assumption, an attempt was made to predict the suitability of new pyroclastic material samples emitted by the La Palma Volcano as growing substrates for vegetables.
Making a Sustainable Difference to People, Processes and Systems: Whole-Systems Approaches to Process Improvement in Health Systems
Authors: McNamara Martin , Ward Marie , Teeling Seán Paul
Published: March 2023

The eighteen papers in this Special Issue, ‘Whole-Systems Approaches to Process Improvement in Health Systems’, address an enduring challenge in healthcare: to improve efficiency with existing or reduced resources, while maintaining safe and effective care [...]
Older People in Emergencies; Addressing Food Insecurity, Health Status and Quality of Life: Evaluating the “365+ Days of Care” Program
Authors: Diamantis Dimitrios V. , Katsas Konstantinos , Kastorini Christina Maria , Mugford Lyndsey , Dalma Nadia , Ramizi Marsellos , Papapanagiotou Ourania , Veloudaki Afroditi , Linos Athena , Kouvari Matina
Published: March 2023

During emergencies, older adults stand among the most vulnerable, facing long-lasting food insecurity and overall health issues. The “365+ Days of Care” food aid program addressed food insecurity and poor quality of life among vulnerable older adults following a devastating wildfire in Greece. Our aim was to evaluate the program’s efficiency, using a process evaluation framework and a partial cost–utility analysis. In total, n = 133 wildfire-hit residents (≥65 years) received daily tailored, pre-cooked meals and/or weekly food packages. The study outcomes were assessed from baseline to 12 months later. Focus groups and interviews (n = 30), researcher observations, and questionnaires were used to assess the beneficiaries’ perception of the initiative. Within the 12-month follow-up period, food insecurity and malnutrition risk decreased, whereas Mediterranean diet adherence; quality of life; and physical, social, and mental health were improved (p < 0.05). A one-point increase in food insecurity was positively associated with improved quality of life, general health, limitation in activities, body pain, vitality, and pain/discomfort (p’s < 0.05), and it was marginally associated with mobility, anxiety/depression, and self-evaluated health status (p’s < 0.1). Quantitative and qualitative data characterized it as successful, acceptable, beneficial, and of high quality. The partial cost–utility ratio was one QALY gained per EUR 22.608. The utilization of well-designed food aid programs during emergencies can alleviate food insecurity and improve quality of life in older adults.
Polygenic Scores in the Direct-to-Consumer Setting: Challenges and Opportunities for a New Era in Consumer Genetic Testing
Authors: Park Jin K. , Lu Christine Y.
Published: March 2023

Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and public intrigue. Although the current consumer genetic testing regime relies on the reporting of individual variants of interest to consumers, there has recently been interest in the possibility of integrating polygenic scores (PGS), which aggregate genetic liability for disease across the entire genome. While PGS have thus far been extensively explored as clinical and public health tools, the use of PGS in consumer genetic testing has not yet received systematic attention, even though they are already in use for some consumer genetic tests. In this narrative review, we highlight the ethical, legal, and social implications of the use of PGS in DTC genetic tests and synthesize existing solutions to these concerns. We organize these concerns into three domains: (1) industry variation; (2) privacy and commercialization; and (3) patient safety and risk. While previously expressed concerns in these domains will remain relevant, the emergence of PGS-based DTC genetic tests raises challenges that will require novel approaches.
Exploration or Exploitation of a Neighborhood Destination: The Role of Social Media Content on the Perceived Value and Trust and Revisit Intention among World Cup Football Fans
Authors: Helal Emad Ahmed , Hassan Thowayeb H. , Abdelmoaty Mostafa A. , Salem Amany E. , Saleh Mahmoud I. , Helal Mohamed Y. , Abuelnasr Magdy Sayed , Mohamoud Yasser Ahmed , Abdou Ahmed H. , Radwan Salaheldeen H. , Szabo-Alexi Paul
Published: March 2023

Over the last decade, social media (SM) has dramatically influenced the tourism sector, and information exchange via SM platforms may affect tourists’ intentions to revisit a tourist destination. In the present study, we investigated the impact of content shared on SM on tourists’ intentions to revisit Saudi Arabia as a neighboring destination to Qatar during the period of a mega-event (Football World Cup). We also assessed the potential mediation effects of the perceived values and trust in local tourism services on such a relationship. A structured survey was distributed to football fans who came to visit Saudi Arabia (n = 300), and a partial least squares structural equation model was constructed to validate this study’s model. Results showed that SM content did not significantly impact the revisit intentions directly. SM content was a significant antecedent predictor of the perceived trust, and the perceived trust predicted future intentions to revisit Saudi Arabia. Therefore, the perceived trust in tourism services was a significant mediator of tourism SM’s effects on tourists’ intentions. However, the mediation path of the perceived value was not statistically significant. Tourism marketers had to ensure that they appropriately convey engaging content that focuses on supporting the trust in a destination, particularly during the periods of mega-events.
Municipal Solid Waste Incineration Fly Ash: From Waste to Cement Manufacturing Resource
Authors: Marieta Cristina , Martín-Garin Alexander , Leon Iñigo , Guerrero Ana
Published: March 2023

This study investigates the possibility of using municipal solid waste incineration fly ash as a supplementary cementitious material to replace part of the clinker in cement. Life cycle assessment has shown that the partial replacement of clinker with blast furnace slag (CEM III) reduces cement’s global warming potential by ~30%, while replacing clinker with fly ash reduces it by up to 55%. When using CEM III as the control binder in cement in which 55 wt% of the clinker was replaced with hydrothermally treated fly ash, the flexural strength decreased by ~60% and the compressive strength by ~65%. When the fly ash was mixed with calcined and vitrified demolition materials, flexural strength decreased by ~30% and compressive strength by ~50%. The hardening of the hydraulic binders fixed the heavy metals in the municipal solid waste incineration fly ash.
Effect of NO2 Aging on the Surface Structure and Thermal Stability of Silicone Rubber with Varying Al(OH)3 Contents
Authors: Fang Jiapeng , Luo Yi , Kuang Shilong , Luo Kai , Xiao Zikang , Peng Xiangyang , Huang Zhen , Wang Zheng , Fang Pengfei
Published: March 2023

In this study, silicone rubber (SiR) with 0, 90, and 180 parts of aluminum hydroxide (Al(OH)3, ATH) contents prepared in the laboratory was treated in a certain concentration of NO2 for 0, 12, 24, and 36 h. Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and thermogravimetry (TG) were used to study the changes in the surface structure and thermal stability of SiR, as well as the influence of Al(OH)3 on the properties of SiR. According to AFM, the root-mean-square roughness of ATH-90 SiR was 192 nm, which was 2.7 times of ATH-0 SiR. With the incorporation of ATH, the surface of SiR became more susceptible to corrosion by NO2. According to FT-IR and XPS, with the increase in aging time, the side chain Si-CH3 of polydimethylsiloxane (PDMS) was oxidized gradually and a few of nitroso -NO2 groups were formed. According to TG, the incorporation of ATH caused the maximum decomposition rate temperature of PDMS to advance from 458.65 °C to 449.37 and 449.26 °C, which shows that the thermal stability of SiR degraded by adding ATH. After NO2 aging, a new decomposition stage appeared between 75 and 220 °C (stage Ⅰ), and this decomposition trend was similar to aluminum nitrate, which was proven to reduce the thermal stability of PDMS. The effects of NO2 on the surface structure and thermal stability of different ATH contents of silicone rubber were preliminarily clarified by a variety of characterization methods, which provided ideas for the development of silicone rubber resistant to NO2 aging.
A New Environmentally Friendly Mortar from Cement, Waste Marble and Nano Iron Slag as Radiation Shielding
Authors: El-Khatib Ahmed M. , Abbas Mahmoud I. , Elzaher Mohamed Abd , Anas M. , El Moniem Mohamed S. Abd , Montasar Mahmoud , Ellithy Ebeid , Alabsy Mahmoud T.
Published: March 2023

Improving mortar shielding properties to preserve environmental and human safety in radiation facilities is essential. Conventional cement mortars, composed of cement, water, and lime aggregate, are crucial for radiation shielding. Using recycled aggregates to produce new mortar and concrete compositions has attracted the attention of several researchers. In the current study, waste marble and iron slag as aggregates are used to create novel cement mortar compositions to study the aggregate’s impact on the radiation attenuation capability of the mortar. Three mortar groups, including a control mortar (CM-Ctrl), were prepared based on cement and waste marble. The other two groups (CM-MIS, CM-NIS), contained 25% iron slag at different particle sizes as a replacement for a waste marble. The study aims to compare iron slag in their micro and nano sizes to discuss the effect of particle size on the mortar radiation capability. For this purpose, the NaI scintillation detector and radioactive point sources (241Am, 133Ba, 137Cs, 60Co, and 152Eu) were utilized to measure several shielding parameters, such as the linear attenuation coefficient (LAC), mass attenuation coefficient (MAC), half-value layer (HVL), tenth-value layer (TVL), and mean free path (MFP), for the produced mortars at different photon energies. Furthermore, the transmission electron microscope (TEM) is used to measure the particle size of the aggregates. In addition, a scanning electron microscope (SEM) is utilized to acquire the cross-section morphologies of the prepared mortars. According to our findings, mortars prepared with nano-iron slag and waste marble offered superior shielding capabilities than mortars containing natural sand or fine crushed stone. The nano iron slag mortar can be utilized in place of typical sand mortar for applications as rendering or plastering materials for building medical diagnostic and CT scanner rooms, due to its improved shielding abilities.
Cauterization of Narrow Root Canals Untouched by Instruments by High-Frequency Current
Authors: Kumagai Hiromichi , Sugaya Tsutomu , Tominaga Toshihiko
Published: March 2023

The mechanical removal of bacteria is fundamental to the treatment of infected root canals, but complete sterilization of biofilms tends not to extend to uninstrumented areas. However, during electrical conduction to a root canal filled with a conductor, the higher impedance where the root canal is narrower generates Joule heat that may result in a large temperature increase and sterilization. The effect of a high-frequency electric current on the wall of a simulated narrow root canal was investigated by scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS). Simulated root canals, 0.1 mm in diameter, were prepared in dentine blocks. The root canal wall was treated with Plank-Rychlo solution for 5 min to create a decalcified layer. The simulated root canal was filled with either saline or NaClO, and 150 or 225 V at 520 kHz was applied for 0 s, 1 s, or 5 s. As the conduction time increased, and when the saline was replaced with NaClO, the proportion with a flat decalcified surface decreased, dentinal tubules and a lava-like morphology were significantly more evident on SEM (p < 0.01), and EDS showed significant decreases in carbon and oxygen and increases in calcium (p < 0.01). It was concluded that filling uninstrumented root canals with NaClO and using electrical conduction for 5 s could incinerate and eliminate the organic material of the root canal wall. The application of high-frequency electric current may lead to the cure of many cases of persistent apical periodontitis.
Enhancing Mechanical Properties of 3D Printing Metallic Lattice Structure Inspired by Bambusa Emeiensis
Authors: Jing Shikai , Li Wei , Ma Guanghao , Cao Xiaofei , Zhang Le , Fang Liu , Meng Jiaxu , Shao Yujie , Shen Biwen , Zhang Changdong , Li Huimin , Wan Zhishuai , Xiao Dengbao
Published: March 2023

Metallic additive manufacturing process parameters, such as inclination angle and minimum radius, impose constraints on the printable lattice cell configurations in complex components. As a result, their mechanical properties are usually lower than their design values. Meanwhile, due to unavoidable process constraints (e.g., additional support structure), engineering structures filled with various lattice cells usually fail to be printed or cannot achieve the designed mechanical performances. Optimizing the cell configuration and printing process are effective ways to solve these problems, but this is becoming more and more difficult and costly with the increasing demand for properties. Therefore, it is very important to redesign the existing printable lattice structures to improve their mechanical properties. In this paper, inspired by the macro- and meso-structures of bamboo, a bionic lattice structure was partitioned, and the cell rod had a radius gradient, similar to the macro-scale bamboo joint and meso-scale bamboo tube, respectively. Experimental and simulated results showed that this design can significantly enhance the mechanical properties without adding mass and changing the printable cell configuration. Finally, the compression and shear properties of the Bambusa-lattice structure were analyzed. Compared with the original scheme, the bamboo lattice structure design can improve the strength by 1.51 times (β=1.5). This proposed strategy offers an effective pathway to manipulate the mechanical properties of lattice structures simultaneously, which is useful for practical applications.
Black Liquor and Wood Char-Derived Nitrogen-Doped Carbon Materials for Supercapacitors
Authors: Tamasauskaite-Tamasiunaite Loreta , Jablonskienė Jolita , Šimkūnaitė Dijana , Volperts Aleksandrs , Plavniece Ance , Dobele Galina , Zhurinsh Aivars , Jasulaitiene Vitalija , Niaura Gediminas , Drabavicius Audrius , Juel Mari , Colmenares-Rausseo Luis , Kruusenberg Ivar , Kaare Kätlin , Norkus Eugenijus
Published: March 2023

Herein, we present a synthesis route for high-efficiency nitrogen-doped carbon materials using kraft pulping residue, black liquor, and wood charcoal as carbon sources. The synthesized nitrogen-doped carbon materials, based on black liquor and its mixture with wood charcoal, exhibited high specific surface areas (SSAs) of 2481 and 2690 m2 g−1, respectively, as well as a high volume of mesopores with an average size of 2.9–4.6 nm. The nitrogen content was approximately 3–4 at% in the synthesized nitrogen-doped carbon materials. A specific capacitance of approximately 81–142 F g−1 was achieved in a 1 M Na2SO4 aqueous solution at a current density of 0.2 A g−1. In addition, the specific capacitance retention was 99% after 1000 cycles, indicating good electrochemical stability.
Recent Advances in Properties and Applications of Carbon Fiber-Reinforced Smart Cement-Based Composites
Authors: Hao Yali , Shi Cheng , Bi Zhenxiao , Lai Ziqiang , She Anming , Yao Wu
Published: March 2023

Under the strategies of low-carbon and environmental protection, promoting green technology innovation to achieve carbon neutrality in the construction field has become a universal goal. As the building material with the highest consumption, concrete has gradually begun to transform into a multi-functional and intelligent product. Therefore, the research on carbon fiber-reinforced cement-based composites (CFRCs) is of relative interest. It mainly uses carbon fibers (CFs) with high elasticity, strength, and conductivity to disperse evenly into the concrete as a functional filler, to achieve the intelligent integration of concrete structures and function innovatively. Furthermore, the electrical conductivity of CFRC is not only related to the content of CFs and environmental factors but also largely depends on the uniform dispersion and the interfacial bonding strength of CFs in cement paste. This work systematically presents a review of the current research status of the enhancement and modification mechanism of CFRC and the evaluation methods of CF dispersion. Moreover, it further discusses the improvement effects of different strengthening mechanisms on the mechanical properties, durability, and smart properties (thermoelectric effect, electrothermal effect, strain-sensitive effect) of CFRC, as well as the application feasibility of CFRC in structural real-time health monitoring, thermal energy harvesting, intelligent deformation adjustment, and other fields. Furthermore, this paper summarizes the problems and challenges faced in the efficient and large-scale applications of CFRCs in civil engineering structures, and accordingly promotes some proposals for future research.
Compact Wearable Antenna with Metasurface for Millimeter-Wave Radar Applications
Authors: de Cos Gómez María Elena , Fernández Álvarez Humberto , Flórez Berdasco Alicia , Las-Heras Andrés Fernando
Published: March 2023

Three metasurfaces (MTS) are designed to be combined with a series end-fed 1 × 10 array antenna with a modified Dolph-Chebyshev distribution for imaging applications in the millimeter frequency range, 24.05–24.25 GHz. A reduction in secondary lobes and an increase in FTBR can be achieved while preserving gain, radiation efficiency, SLL and size using an MTS–array combination. Moreover, as a result of each single-layer MTS–array combination, operation bandwidth is widened, with gain and radiation efficiency enhancement. The overall devices’ size is 86.8 × 12 × 0.762 mm3. The envisioned application is collision avoidance in aid to visually impaired people at a medium-long distance.
The Effect of Addition Potassium Permanganate on Bond Strength of Hot-Dip Galvanized Plain Bars with Cement Paste
Authors: Pokorný Petr , Vacek Vítězslav , Prodanovic Nikola , Zabloudil Adam , Hurtig Karel
Published: March 2023

In this paper, the effect of gradually increasing amounts of KMnO4 (10−4, 10−3, 10−2 mol·L−1) in cement paste on the bond strength of a plain hot-dip galvanized steel bar was evaluated. The open-circuit potential of HDG samples in cement paste with various additions of MnO4− was monitored in order to follow a transfer of zinc from activity to passivity. Furthermore, the influence of the addition of these anions on the physicochemical properties of normal-strength concrete or cement paste was evaluated by means of hydration heat measurements, X-ray diffraction analysis, and compressive strength. The effective concentration of MnO4− anions prevents the corrosion of the coating with hydrogen evolution and ensures that the bond strength is not reduced by their action, which was determined to be 10−3 mol·L−1. Lower additions of MnO4− anions (10−4 mol·L−1) are ineffective in this respect. On the other hand, higher additions of MnO4− anions (10−2 mol·L−1), although they ensure the corrosion of the coating in fresh concrete without hydrogen evolution, but affect the hydration process of the cement paste that was demonstrated by slight water separation.
Chemical Dissolution-Assisted Ultrafine Grinding for Preparation of Quasi-Spherical Colloids of Zinc Oxide
Authors: Huang Guanghua , Chen Zening , Pan Zhidong , Xu Yan , Hu Hanlin , Wang Yanmin
Published: March 2023

Submicron-sized quasi-spherical zinc oxide (ZnO) particles were prepared by wet ultrafine grinding in a stirred media mill under various conditions. The effects of parameters (i.e., solution type, acid or alkali concentration, solid content and grinding time) on the particle median size (d50), particle size distribution (PSD) and sphericity of ZnO particles was investigated. The results show that submicron-sized quasi-spherical particles (i.e., d50: 370 nm, uniformity coefficient (n) of 2.28 and sphericity of 0.91) can be obtained when the micron-sized ZnO particles are ground for 30 min in a CH3COOH solution at a concentration of 0.010 mol/L with 20 wt.% of solid content. The chemical dissolution of ZnO particles ground in the presence and absence of acetic acid is discussed. It is indicated that chemical dissolution accelerated due to the mechanochemical effects could reduce the particle size, obtain a narrower PSD and enhance the sphericity. In addition, the functions of selection and breakage were used to analyze the grinding mechanism of ZnO particles.
Recent Advancement and Structural Engineering in Transition Metal Dichalcogenides for Alkali Metal Ions Batteries
Authors: Ullah Nabi , Guziejewski Dariusz , Yuan Aihua , Shah Sayyar Ali
Published: March 2023

Currently, transition metal dichalcogenides-based alkaline metal ion batteries have been extensively investigated for renewable energy applications to overcome the energy crisis and environmental pollution. The layered morphologys with a large surface area favors high electrochemical properties. Thermal stability, mechanical structural stability, and high conductivity are the primary features of layered transition metal dichalcogenides (L-TMDs). L-TMDs are used as battery materials and as supporters for other active materials. However, these materials still face aggregation, which reduces their applicability in batteries. In this review, a comprehensive study has been undertaken on recent advancements in L-TMDs-based materials, including 0D, 1D, 2D, 3D, and other carbon materials. Types of structural engineering, such as interlayer spacing, surface defects, phase control, heteroatom doping, and alloying, have been summarized. The synthetic strategy of structural engineering and its effects have been deeply discussed. Lithium- and sodium-ion battery applications have been summarized in this study. This is the first review article to summarize different morphology-based TMDs with their intrinsic properties for alkali metal ion batteries (AMIBs), so it is believed that this review article will improve overall knowledge of TMDs for AMIBS applications.
Do Innovation Metrics Reflect Sustainable Policy Making in Europe? A Comparative Study Case on the Carpathian and Alpine Mountain Regions
Authors: Coca Andrei , Gabor Manuela Rozalia , Susanu Irina Olimpia
Published: March 2023

This paper questions the evaluation of innovation systems and innovation measurements and the effectiveness of innovation policies applied at the territorial level by assessing whether the existing European regional scoreboard is effective in providing accurate inputs for decision-makers in mountainous regions. The aim of the research is to provide, through comparative analysis by using statistical multi-methods of two mountainous macro-regions (the Alps and the Carpathians), a possible and available path to develop novel perspectives and alternative views on innovation systems’ performance for informed and territorial-based policy making by using the indicators of the Regional Innovation Scoreboard. The methodology used includes descriptive statistics, chi-square bivariate test, Student’s t test, one-way ANOVA with Bonferroni post hoc multiple comparisons, multilinear regression analysis, and decision tree with CRT (classification and regression trees) algorithm. Our results emphasize the similarities and differences between the Alpine and Carpathian mountain regions, find the best predictors for each mountain region, and provide a scientific basis for the development of a holistic approach linking measurement theory, innovation systems, innovation policies, and their territorial approach toward sustainable development of mountain areas. The paper’s contribution is relevant in the context of remote, rural, and mountain areas, which are usually left behind in terms of innovation chances and in the context of the COVID-19 aftermath with budget constraints. The present results are pertinent for designing effective smart specialization strategies in these regions due to the difficulties that most remote areas and less developed regions are facing in developing innovation policies.
Wavefront Recovery for Multiple Sun Regions in Solar SCAO Scenarios with Deep Learning Techniques
Authors: Suárez Gómez Sergio Luis , García Riesgo Francisco , Pérez Fernández Saúl , Iglesias Rodríguez Francisco Javier , Díez Alonso Enrique , Santos Rodríguez Jesús Daniel , De Cos Juez Francisco Javier
Published: March 2023

The main objective of an Adaptive Optics (AO) system is to correct the aberrations produced in the received wavefronts, caused by atmospheric turbulence. From some measures taken by ground-based telescopes, AO systems must reconstruct all the turbulence traversed by the incoming light and calculate a correction. The turbulence is characterized as a phenomenon that can be modeled as several independent, random, and constantly changing layers. In the case of Solar Single-Conjugated Adaptive Optics (Solar SCAO), the key is to reconstruct the turbulence on-axis with the direction of the observation. Previous research has shown that ANNs are a possible alternative when they have been trained in the Sun’s regions where they must make the reconstructions. Along this research, a new solution based on Artificial Intelligence (AI) is proposed to predict the atmospheric turbulence from the data obtained by the telescope sensors that can generalize recovering wavefronts in regions of the sun completely unknown previously. The presented results show the quality of the reconstructions made by this new technique based on Artificial Neural Networks (ANNs), specifically the Multi-layer Perceptron (MLP).
Curves Related to the Gergonne Point in an Isotropic Plane
Authors: Jurkin Ema , Šimić Horvath Marija
Published: March 2023

The notion of the Gergonne point of a triangle in the Euclidean plane is very well known, and the study of them in the isotropic setting has already appeared earlier. In this paper, we give two generalizations of the Gergonne point of a triangle in the isotropic plane, and we study several curves related to them. The first generalization is based on the fact that for the triangle ABC and its contact triangle AiBiCi, there is a pencil of circles such that each circle km from the pencil the lines AAm, BBm, CCm is concurrent at a point Gm, where Am, Bm, Cm are points on km parallel to Ai,Bi,Ci, respectively. To introduce the second generalization of the Gergonne point, we prove that for the triangle ABC, point I and three lines q1,q2,q3 through I there are two points G1,2 such that for the points Q1,Q2,Q3 on q1,q2,q3 with d(I,Q1)=d(I,Q2)=d(I,Q3), the lines AQ1,BQ2 and CQ3 are concurrent at G1,2. We achieve these results by using the standardization of the triangle in the isotropic plane and simple analytical method.
Simple and Fast Pesticide Nanosensors: Example of Surface Plasmon Resonance Coumaphos Nanosensor
Authors: Oymen Beste , Jalilzadeh Mitra , Yılmaz Fatma , Aşır Süleyman , Türkmen Deniz , Denizli Adil
Published: March 2023

Here, a molecular imprinting technique was employed to create an SPR-based nanosensor for the selective and sensitive detection of organophosphate-based coumaphos, a toxic insecticide/veterinary drug often used. To achieve this, UV polymerization was used to create polymeric nanofilms using N-methacryloyl-l-cysteine methyl ester, ethylene glycol dimethacrylate, and 2-hydroxyethyl methacrylate, which are functional monomers, cross-linkers, and hydrophilicity enabling agents, respectively. Several methods, including scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle (CA) analyses, were used to characterize the nanofilms. Using coumaphos-imprinted SPR (CIP-SPR) and non-imprinted SPR (NIP-SPR) nanosensor chips, the kinetic evaluations of coumaphos sensing were investigated. The created CIP-SPR nanosensor demonstrated high selectivity to the coumaphos molecule compared to similar competitor molecules, including diazinon, pirimiphos-methyl, pyridaphenthion, phosalone, N-2,4(dimethylphenyl) formamide, 2,4-dimethylaniline, dimethoate, and phosmet. Additionally, there is a magnificent linear relationship for the concentration range of 0.1–250 ppb, with a low limit of detection (LOD) and limit of quantification (LOQ) of 0.001 and 0.003 ppb, respectively, and a high imprinting factor (I.F.4.4) for coumaphos. The Langmuir adsorption model is the best appropriate thermodynamic approach for the nanosensor. Intraday trials were performed three times with five repetitions to statistically evaluate the CIP-SPR nanosensor’s reusability. Reusability investigations for the two weeks of interday analyses also indicated the three-dimensional stability of the CIP-SPR nanosensor. The remarkable reusability and reproducibility of the procedure are indicated by an RSD% result of less than 1.5. Therefore, it has been determined that the generated CIP-SPR nanosensors are highly selective, rapidly responsive, simple to use, reusable, and sensitive for coumaphos detection in an aqueous solution. An amino acid, which was used to detect coumaphos, included a CIP-SPR nanosensor manufactured without complicated coupling methods and labelling processes. Liquid chromatography with tandem mass spectrometry (LC/MS-MS) studies was performed for the validation studies of the SPR.
A Model Linking Compressive Strength and Porosity in Ternary System: Metakaolin, Limestone, Cement
Authors: Gonnon Pascal , Lootens Didier
Published: March 2023

The replacement of traditional cement with high clinker content should be achieved quickly to lower the carbon footprint of mortar and concrete. Cement is responsible for about 70% of the carbon footprint of cementitious materials. Current research suggests that the use of limestone and metakaolin or calcined clay could replace the current four gigatons of clinker produced. Here, binary systems composed of limestone/cement and metakaolin/cement are first studied to determine the individual impact of fine limestone and diverse fine metakaolins on the flow and compressive strength of the material. The flow properties are correlated with the surface areas of clinker and metakaolin and are almost independent of the limestone content. A model based on a linear relationship between compressive strength and porosity is used to estimate the reactivity of cement, limestone and metakaolin. An excellent correlation is obtained with the two binary systems and confirmed with the ternary systems using the same reactivity factors. The presented model allows the determination of the impact of each of the three components on compressive strength development. Limestone and metakaolin accelerate the hydration of clinker, leading to higher early strength, proportionally to their surface area. The reactivity of metakaolin is also found to be directly related to its mean size or surface area.
Composition and Biological Properties of Blanched Skin and Blanch Water Belonging to Three Sicilian Almond Cultivars
Authors: Ingegneri Mariarosaria , Smeriglio Antonella , Rando Rossana , Gervasi Teresa , Tamburello Maria Pia , Ginestra Giovanna , La Camera Erminia , Pennisi Rosamaria , Sciortino Maria Teresa , Mandalari Giuseppina , Trombetta Domenico
Published: March 2023

The almond industry produces, by bleaching and stripping, two by-products: blanched skin (BS) and blanch water (BW). The aim of this study was to investigate the nutritional and polyphenolic profile, as well as the antioxidant, antimicrobial, antiviral, and potential prebiotic effects of BS and BW from three different Sicilian cultivars. The total phenols and flavonoids contents were ≥1.72 and ≥0.56 g gallic acid equivalents and ≥0.52 and ≥0.18 g rutin equivalents/100 g dry extract (DE) in BS and BW, respectively. The antioxidant activity, evaluated by 2,2-diphenyl-1-picrylhydrazyl scavenging ability, trolox equivalent antioxidant capacity, ferric-reducing antioxidant power, and oxygen radical absorbance capacity, was ≥3.07 and ≥0.83 g trolox equivalent/100 g DE in BS and BW, respectively. Isorhamnetin-3-O-glucoside was the most abundant flavonoid detected in both by-products. No antimicrobial effect was recorded, whereas BS samples exerted antiviral activity against herpes simplex virus 1 (EC50 160.96 μg/mL). BS also showed high fibre (≥52.67%) and protein (≥10.99) contents and low fat (≤15.35%) and sugars (≤5.55%), making it nutritionally interesting. The present study proved that the cultivar is not a discriminating factor in determining the chemical and biological properties of BS and BW.
Low-Grade Inflammation and Ultra-Processed Foods Consumption: A Review
Authors: Tristan Asensi Marta , Napoletano Antonia , Sofi Francesco , Dinu Monica
Published: March 2023

Low-grade inflammation alters the homeostasis of the organism and favors the onset of many chronic diseases. The global growth in the prevalence of noncommunicable diseases in recent years has been accompanied by an increase in the consumption of ultra-processed foods (UPF). Known to be hyperpalatable, economic and ready-to-eat, increased consumption of UPF has already been recognized as a risk factor for several chronic diseases. Different research groups have tried to investigate whether UPF consumption could promote low-grade inflammation and thus favor the development of noncommunicable diseases. Current evidence highlights the adverse health effects of UPF characteristics, not only due to the nutrients provided by a diet rich in UPF, but also due to the non-nutritive components present in UPF and the effect they may have on gut health. This review aims to summarize the available evidence on the possible relationship between excessive UPF consumption and modulation of low-grade inflammation, as potential promoters of chronic disease.
Curcumin Confers Anti-Inflammatory Effects in Adults Who Recovered from COVID-19 and Were Subsequently Vaccinated: A Randomized Controlled Trial
Authors: Fessler Samantha N. , Chang Yung , Liu Li , Johnston Carol S.
Published: March 2023

COVID-19 infection and vaccination offer disparate levels of defense against reinfection and breakthrough infection. This study was designed to examine the effects of curcumin supplementation, specifically HydroCurc (CURC), versus placebo (CON) on circulating inflammatory biomarkers in adults who had previously been diagnosed with COVID-19 and subsequently received a primary series of monovalent vaccine doses. This study was conducted between June 2021 and May 2022. Participants were randomized to receive CURC (500 mg) or CON capsules twice daily for four weeks. Blood sampling was completed at baseline and week-4 and analyzed for biomarkers. Linear regression was utilized to examine the between-group differences in post-trial inflammatory biomarker levels, adjusting for baseline and covariates including age, sex, race/ethnicity, and interval between COVID-19 diagnosis and trial enrollment. The sample (n = 31) was 71% female (Age 27.6 ± 10.4 y). The CURC group exhibited significantly lower post-trial concentrations of proinflammatory IL-6 (β = −0.52, 95%CI: −1.03, −0.014, p = 0.046) and MCP-1 (β = −0.12, 95%CI: −0.23, −0.015, p = 0.027) compared to CON, adjusting for baseline and covariates. Curcumin intake confers anti-inflammatory activity and may be a promising prophylactic nutraceutical strategy for COVID-19. These results suggest that 4 weeks of curcumin supplementation resulted in significantly lower concentrations of proinflammatory cytokines in adults who recovered from COVID-19 infection and were subsequently vaccinated.
Maternal Intake of Polyunsaturated Fatty Acids in Autism Spectrum Etiology and Its Relation to the Gut Microbiota: What Do We Know?
Authors: Rodrigues Elisana Lima , Figueiredo Priscila Silva , Marcelino Gabriela , de Cássia Avellaneda Guimarães Rita , Pott Arnildo , Santana Lidiani Figueiredo , Hiane Priscila Aiko , do Nascimento Valter Aragão , Bogo Danielle , de Cássia Freitas Karine
Published: March 2023

Maternal food habits and gut microbiota composition have potential effects on fetal neurodevelopment, impacting Autism Spectrum Disorder (ASD). Our research aims to outline the relationship that ingestion of polyunsaturated fatty acids (PUFAs) and the composition of maternal gut microbiota have with the possible development of ASD in offspring. We suggest that genetic factors could be related to the different conversions between unsaturated fatty acids according to sex and, mainly, the impact of the pregnancy diet on the higher or lower risk of neurological impairments. The proportion of the phyla Firmicutes/Bacteroidetes is high with an increased consumption of linoleic acid (LA, n-6 PUFA), which is associated with maternal intestinal dysbiosis and consequently starts the inflammatory process, harming myelinization. In contrast, the consumption of α-linolenic acid (ALA, n-3 PUFA) tends to re-establish the balance of the maternal microbiota with anti-inflammatory action. Moreover, human observational studies showed a strong correlation between the consumption of n-3 PUFA, mainly above 340 g of fish per week, with beneficial effects on infant neurodevelopment. Therefore, we suggest that the proper intake of foods rich in n-3 PUFAs and their supplementation during pregnancy until lactation has an impact on reducing the development of ASD. Controlled studies with n-3 PUFA supplementation are still necessary to verify the ideal dose and the best form of administration.
Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring
Authors: Hurley Lauren , Jauhal Jesse , Ille Sharadyn , Pull Kasey , Malysheva Olga V. , Jadavji Nafisa M.
Published: March 2023

Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment. However, the impact of maternal dietary deficiencies on offspring stroke outcomes later in life remains undefined. The aim of this study was to investigate the role of maternal dietary deficiencies in folic acid and choline on ischemic stroke outcomes in middle-aged offspring. Female mice were maintained on either a control or deficient diet prior to and during pregnancy and lactation. At 10 months of age ischemic stroke was induced in male and female offspring. Stroke outcome was assessed by measuring motor function and brain tissue. There was no difference in offspring motor function; however, sex differences were present. In brain tissue, maternal dietary deficiency increased ischemic damage volume and offspring from deficient mothers had reduced neurodegeneration and neuroinflammation within the ischemic region. Furthermore, there were changes in plasma 1C metabolites as a result of maternal diet and sex. Our data indicate that maternal dietary deficiencies do not impact offspring behavior after ischemic stroke but do play a role in brain histology and one-carbon metabolite levels in plasma. Additionally, this study demonstrates that the sex of mice plays an important role in stroke outcomes.
Meroterpenoids from Gongolaria abies-marina against Kinetoplastids: In Vitro Activity and Programmed Cell Death Study
Authors: Nicolás-Hernández Desirée San , Rodríguez-Expósito Rubén L. , López-Arencibia Atteneri , Bethencourt-Estrella Carlos J. , Sifaoui Ines , Salazar-Villatoro Lizbeth , Omaña-Molina Maritza , Fernández José J. , Díaz-Marrero Ana R. , Piñero José E. , Lorenzo-Morales Jacob
Published: March 2023

Leishmaniasis and Chagas disease affect millions of people worldwide. The available treatments against these parasitic diseases are limited and display multiple undesired effects. The brown alga belonging to the genus Gongolaria has been previously reported as a source of compounds with different biological activities. In a recent study from our group, Gongolaria abies-marine was proven to present antiamebic activity. Hence, this brown alga could be a promising source of interesting molecules for the development of new antiprotozoal drugs. In this study, four meroterpenoids were isolated and purified from a dichloromethane/ethyl acetate crude extract through a bioguided fractionation process targeting kinetoplastids. Moreover, the in vitro activity and toxicity were evaluated, and the induction of programmed cell death was checked in the most active and less toxic compounds, namely gongolarone B (2), 6Z-1′-methoxyamentadione (3) and 1′-methoxyamentadione (4). These meroterpenoids triggered mitochondrial malfunction, oxidative stress, chromatin condensation and alterations of the tubulin network. Furthermore, a transmission electron microscopy (TEM) image analysis showed that meroterpenoids (2–4) induced the formation of autophagy vacuoles and ER and Golgi complex disorganization. The obtained results demonstrated that the mechanisms of action at the cellular level of these compounds were able to induce autophagy as well as an apoptosis-like process in the treated parasites.
Rifampicin Enhanced Carbapenem Activity with Improved Antibacterial Effects and Eradicates Established Acinetobacter baumannii Biofilms
Authors: Nwabor Lois Chinwe , Chukamnerd Arnon , Nwabor Ozioma Forstinus , Pomwised Rattanaruji , Voravuthikunchai Supayang P. , Chusri Sarunyou
Published: March 2023

Biofilm-mediated infections are critical to public health and a leading cause of resistance among pathogens, amounting to a prolonged hospital stay and increased mortality rate in the intensive care unit. In this study, the antibacterial and antibiofilm activities of rifampicin or carbapenem monotherapies were compared with rifampicin and carbapenem combination therapies against rifampicin-resistant and carbapenem-resistant Acinetobacter baumannii isolates. Among 29 CRAB isolates, 24/29 (83%) were resistant to rifampicin, with MIC values between 2–256 µg/mL. Checkerboard assays disclosed that combination therapies at FICIs between 1/8 and 1/4 improved the activity of carbapenems at subinhibitory concentrations. Time-kill kinetics indicated a 2- to 4-log reduction at 1/2 MIC rifampicin + 1/4 MIC carbapenem and 1/4 MIC rifampicin + 1/4 MIC carbapenem against the isolates, with the MIC values ranging from 2–8 µg/mL. The MTT assay revealed a dose-dependent decrease of the cell viability of established bacterial biofilm at 4 MIC rifampicin + 2 MIC carbapenems, with a percentage reduction of 44–75%, compared with monotherapies at 16 MIC. Scanning electron microscopy further confirmed bacterial cell membrane disruption, suggesting a synergism between carbapenem and rifampicin against a representative isolate. The findings demonstrated that the combination of rifampicin with carbapenems could improve antibacterial activities and eradicate established Acinetobacter baumannii biofilm.
Block Copolymer Micelles Encapsulating Au(III) Bis(Dithiolene) Complexes as Promising Nanostructures with Antiplasmodial Activity
Authors: Santos Joana F. , Azevedo Raquel , Prudêncio Miguel , Marques Fernanda , Le Gal Yann , Lorcy Dominique , Fernandes Célia
Published: March 2023

Block copolymer micelles (BCMs) can be used to improve the solubility of lipophilic drugs and increase their circulation half-life. Hence, BCMs assembled from MePEG-b-PCL were evaluated as drug delivery systems of gold(III) bis(dithiolene) complexes (herein AuS and AuSe) to be employed as antiplasmodial drugs. These complexes exhibited remarkable antiplasmodial activity against liver stages of the Plasmodium berghei parasite, and low toxicity in a model of zebrafish embryos. To improve the complexes’ solubility, BCMs were loaded with AuS, AuSe, and the reference drug primaquine (PQ). PQ-BCMs (Dh = 50.9 ± 2.8 nm), AuSe-BCMs (Dh = 87.1 ± 9.7 nm), and AuS-BCMs (Dh = 72.8 ± 3.1 nm) were obtained with a loading efficiency of 82.5%, 55.5%, and 77.4%, respectively. HPLC analysis and UV–Vis spectrophotometry showed that the compounds did not suffer degradation after encapsulation in BCMs. In vitro release studies suggest that AuS/AuSe-BCMs present a more controlled release compared with PQ-loaded BCMs. The antiplasmodial hepatic activity of the drugs was assessed in vitro and results indicate that both complexes present higher inhibitory activity than PQ, although encapsulated AuS and AuSe presented lower activity than their non-encapsulated counterparts. Nevertheless, these results suggest that the use of BCMs as delivery vehicles for lipophilic metallodrugs, particularly AuS and AuSe, could enable the controlled release of complexes and improve their biocompatibility, constituting a promising alternative to conventional antimalarial treatments.