bluuebunny/crossref_metadata_2025 huggingface dataset:
RecJ3/4-aRNase J form a Ubl-associated nuclease complex functioning in survival against DNA damage in
Haloferax volcanii
Authors: Jia Huiyong , Dantuluri Swathi , Margulies Shae , Smith Victoria , Lever Rebecca , Allers Thorsten , Koh Jin , Chen Sixue , Maupin-Furlow Julie A.
Published: July 2023

Nucleases are strictly regulated and often localized in the cell to avoid the uncontrolled degradation of DNA and RNA. Here, a new type of nuclease complex, composed of RecJ3, RecJ4, and aRNase J, was identified through its ATP-dependent association with the ubiquitin-like SAMP1 and AAA-ATPase Cdc48a. The complex was discovered in
Haloferax volcanii
, an archaeon lacking an RNA exosome. Genetic analysis revealed aRNase J to be essential and RecJ3, RecJ4, and Cdc48a to function in the recovery from DNA damage including genotoxic agents that generate double-strand breaks. The RecJ3:RecJ4:aRNase J complex (isolated in 2:2:1 stoichiometry) functioned primarily as a 3′−5′ exonuclease in hydrolyzing RNA and ssDNA, with the mechanism non-processive for ssDNA. aRNase J could also be purified as a homodimer that catalyzed endoribonuclease activity and, thus, was not restricted to the 5′−3′ exonuclease activity typical of aRNase J homologs. Moreover, RecJ3 and RecJ4 could be purified as a 560-kDa subcomplex in equimolar subunit ratio with nuclease activities mirroring the full RecJ3/4-aRNase J complex. These findings prompted reconstitution assays that suggested RecJ3/4 could suppress, alter, and/or outcompete the nuclease activities of aRNase J. Based on the phenotypic results, this control mechanism of aRNase J by RecJ3/4 is not necessary for cell growth but instead appears important for DNA repair.

IMPORTANCE

Nucleases are critical for various cellular processes including DNA replication and repair. Here, a dynamic type of nuclease complex is newly identifiedidentifiedidentifiedin the archaeon
Haloferax volcanii
, which is missing the canonical RNA exosome. The complex, composed of RecJ3, RecJ4, and aRNase J, functions primarily as a 3′−5′ exonuclease and was discovered through its ATP-dependent association with the ubiquitin-like SAMP1 and Cdc48a. aRNase J alone forms a homodimer that has endonuclease function and, thus, is not restricted to 5′−3′ exonuclease activity typical of other aRNase J enzymes. RecJ3/4 appears to suppress, alter, and/or outcompete the nuclease activities of aRNase J. While aRNase J is essential for growth, RecJ3/4, Cdc48a, and SAMPs are important for recovery against DNA damage. These biological distinctions may correlate with the regulated nuclease activity of aRNase J in the RecJ3/4-aRNaseJ complex.
Genome characteristics of the
optrA
-positive
Clostridium perfringens
strain QHY-2 carrying a novel plasmid type
Authors: Wu Ke , Li Zhe , Fang Mingjin , Yuan Yuan , Fox Edward M. , Liu Yingqiu , Li Ruichao , Bai Li , Zhang Wen , Zhang Wei-Min , Yang Qi , Chang Lingling , Li Pu , Wang Xinglong , Wang Juan , Yang Zengqi
Published: July 2023

Clostridium perfringens
is a bacterial species of importance to both public and animal health. The gene
optrA
is the first gene that confers resistance to the tedizolid, a last-resort antimicrobial agent in human medicine. Herein, we whole-genome sequenced and analyzed one
optrA
-positive
C. perfringens
strain QHY-2 from Tibetan sheep in Qinghai province and identified one
optrA
plasmid pQHY-2. The plasmid shared similar structure with the
optrA
-positive plasmids p2C45 and p21-D-5b previously identified in
C. perfringens
, demonstrating the potential horizontal transmission of the
optrA
plasmids among
C. perfringens
strains. Annotation of the
optrA
-positive plasmids showed
optrA
and
erm
(A) located on a segment flanked by IS element IS
1216E
, and
fexA
,
optrA,
and
erm
(A) located on a segment flanked by IS element IS
Vlu1
, which revealed the possible dissemination mechanism. Additionally, a Tn
6218
-like transposon carrying
aac(6′)-aph(2″
) and
erm
(B) was also detected on pQHY-2, demonstrating the transposition of Tn
6218
and spread of antibiotic resistance among
Clostridium
bacteria. Molecular analysis indicated the
optrA
-positive plasmids belonged to a plasmid type distinct from the pCW3-like plasmids, pCP13-like plasmids, or pIP404-like plasmids. Further structure analysis showed they might be formed by inserting segments into plasmid pCPCPI53k-r1_1, which coexist with two pCW3-like plasmids and one pCP13-like plasmid in
C. perfringens
strain CPI 53k-r1 isolated from a healthy human in Finland.

IMPORTANCE

Antimicrobial resistance is now a global concern posing threats to food safety and public health. The pCW3-like plasmids can encode several main toxin genes and three antibiotic resistance genes (ARGs), including
tetA
(P),
tetB
(P), and
erm
(B), which used to be considered as the main carrier of ARGs in
Clostridium perfringens
. In this study, we found the
optrA
plasmids, which belonged to a novel plasmid type, could also harbor many other ARGs, indicating this type of plasmid might be the potential repository of ARGs in
C. perfringens
. Additionally, this type of plasmid could coexist with the pCW3-like plasmids and pCP13-like plasmids that encoded toxin genes associated with gastrointestinal diseases, which showed the potential threat to public health.
Comparative Lysine Acetylome Analysis of Y. pestis YfiQ/CobB Mutants Reveals that Acetylation of SlyA Lys73 Significantly Promotes Biofilm Formation of Y. pestis
Authors: Tan Yafang , Liu Wanbing , Chen Yuling , Zhou Yazhou , Song Kai , Cao Shiyang , Zhang Yuan , Song Yajun , Deng Haiteng , Yang Ruifu , Du Zongmin
Published: July 2023

Yersinia pestis
is the etiological agent of plague, historically responsible for three global pandemics. The 2017 plague epidemic in Madagascar was a reminder that
Y. pestis
remains a real threat in many parts of the world.
Combining Genome Surveillance and Metadata To Characterize the Diversity of Staphylococcus aureus Circulating in an Italian Hospital over a 9-Year Period
Authors: Postiglione U. , Batisti Biffignandi G. , Corbella M. , Merla C. , Olivieri E. , Petazzoni G. , Feil E. J. , Bandi C. , Cambieri P. , Gaiarsa S. , Brilli M. , Sassera D.
Published: July 2023

Genome sequencing is an important tool in clinical microbiology, as it allows in-depth characterization of isolates of interest and can propel genome-based surveillance studies. Such studies can benefit from
ad hoc
methods of sample selection to capture the genomic diversity present in a data set.
Characterization of
In Vitro
Resistance to Linezolid in Mycobacterium abscessus
Authors: Negatu Dereje A. , Aragaw Wassihun Wedajo , Dartois Véronique , Dick Thomas
Published: July 2023

The protein synthesis inhibitor linezolid is used for the treatment of lung disease caused by
Mycobacterium abscessus
. However, many strains of the bacterium show poor susceptibility to the antibiotic.
High-Cadence Observations of Magnetic Field Dynamics and Photospheric Emission Sources in the Eruptive Near-the-Limb X4.9 Solar Flare on 25 February, 2014: Evidences for Two-Stage Magnetic Reconnection during the Impulsive Phase
Authors: Sharykin I. N. , Zimovets I. V. , Radivon A. V.
Published: July 2023

Abstract—

We present an analysis of the pre-limb eruptive X4.9 solar flare on February 25, 2014, by means of which we confirm a hypothesis of the two-stage energy release corresponding to two magnetic reconnection regimes in the flare impulsive phase. This flare is selected, firstly, because of its morphological peculiarities suggesting the presence of the two energy release stages. Secondly, the flare was very suitably located near the solar limb and it was well-observed by many instruments. We performed an analysis of multiwavelength observational data of this flare region to find a connection between changes of the photospheric magnetic field, morphology of hard and soft X-ray sources, dynamics of the photospheric optical emission sources, metric radio bursts, and kinematics of an eruptive structure. The simultaneous usage of the line-of-sight and vector Helioseismic Magnetic Imager (HMI) magnetograms allowed us to trace magnetic field changes during the flare impulsive phase with high temporal resolution. HMI filtergrams allowed to trace displacement of the photospheric emission sources, associated with the magnetic reconnection, with very high temporal resolution up to 2 s. Using all observational results, we argue that the found flare stages are characterized by the following magnetic reconnection regimes. The first stage is predominantly characterized by the three-dimensional zipping reconnection in the strong sheared magnetic field assuming the tether-cutting geometry. The second stage corresponds to the so-called “standard” model of eruptive flares with the quasi-two-dimensional reconnection below the eruptive flux-rope. All observational peculiarities of these two stages are discussed in details.
Method to Reveal and Investigate Almost 2D Fermi Surfaces in Layered Conductors: Universal Resistivity in a Parallel Magnetic Field
Authors: Lebed A. G.
Published: July 2023

We suggested an original method to investigate the Fermi surfaces (FSs) in the quasi-two-dimensional conductors some time ago [A.G. Lebed and N.N. Bagmet, Phys. Rev. B 55, R8654 (1997)]. It was based on a consideration of a perpendicular conductivity in quasi-two-dimensional metals in parallel magnetic fields in the framework of the Boltzmann kinetic equation, where it was shown that the conductivity was independent on impurities. In this paper, we demonstrate that the above mentioned result is much more general than the kinetic equation and can be obtained even in a fully quantum mechanical case. We suggest to investigate this possible phenomenon in the quasi-two-dimensional organic, high-$${{T}_{c}}$$, and some others superconductors in a metallic phase to judge if the Fermi liquid picture is valid for them or not. If the Fermi liquid picture is valid, then study of the perpendicular resistivity in the rotated parallel magnetic field allows to extract important information about the two-dimensional Fermi surfaces.
Burden of serious harms from diagnostic error in the USA
Authors: Newman-Toker David E , Nassery Najlla , Schaffer Adam C , Yu-Moe Chihwen Winnie , Clemens Gwendolyn D , Wang Zheyu , Zhu Yuxin , Saber Tehrani Ali S. , Fanai Mehdi , Hassoon Ahmed , Siegal Dana
Published: July 2023

Background

Diagnostic errors cause substantial preventable harms worldwide, but rigorous estimates for total burden are lacking. We previously estimated diagnostic error and serious harm rates for key dangerous diseases in major disease categories and validated plausible ranges using clinical experts.

Objective

We sought to estimate the annual US burden of serious misdiagnosis-related harms (permanent morbidity, mortality) by combining prior results with rigorous estimates of disease incidence.

Methods

Cross-sectional analysis of US-based nationally representative observational data. We estimated annual incident vascular events and infections from 21.5 million (M) sampled US hospital discharges (2012–2014). Annual new cancers were taken from US-based registries (2014). Years were selected for coding consistency with prior literature. Disease-specific incidences for 15 major vascular events, infections and cancers (‘Big Three’ categories) were multiplied by literature-based rates to derive diagnostic errors and serious harms. We calculated uncertainty estimates using Monte Carlo simulations. Validity checks included sensitivity analyses and comparison with prior published estimates.

Results

Annual US incidence was 6.0 M vascular events, 6.2 M infections and 1.5 M cancers. Per ‘Big Three’ dangerous disease case, weighted mean error and serious harm rates were 11.1% and 4.4%, respectively. Extrapolating to all diseases (including non-‘Big Three’ dangerous disease categories), we estimated total serious harms annually in the USA to be 795 000 (plausible range 598 000–1 023 000). Sensitivity analyses using more conservative assumptions estimated 549 000 serious harms. Results were compatible with setting-specific serious harm estimates from inpatient, emergency department and ambulatory care. The 15 dangerous diseases accounted for 50.7% of total serious harms and the top 5 (stroke, sepsis, pneumonia, venous thromboembolism and lung cancer) accounted for 38.7%.

Conclusion

An estimated 795 000 Americans become permanently disabled or die annually across care settings because dangerous diseases are misdiagnosed. Just 15 diseases account for about half of all serious harms, so the problem may be more tractable than previously imagined.
Simulating polymer drag reduction using a modified mixing length in zero pressure gradient
Authors: White Joshua J. , Holloway A.G.L. , Jeans T.L.
Published: July 2023

It is known that a small concentration of polymer introduced to the boundary layer can produce a significant drag reduction for liquid flows. This effect has been extensively studied for internal flow and polymer injection in external flow. More recently, select external flow research has focused on drag reduction for ships where polymer is introduced by ablation of surface coatings. The present article introduces a simple yet effective model for simulating polymers in the boundary layer. That is a step toward a practical methodology for simulating the effect of ablative polymer paint. For the case of zero pressure gradient boundary layers, measured polymer drag reduction can be closely reproduced, to less than 10% error, by modifying the empirical von Kármán and van Driest constants in the simple mixing length turbulence model. Potential avenues for implementation in standard commercially available computational fluid dynamics solvers are explored.
Computer-Aided Classification of Cell Lung Cancer Via PET/CT Images Using Convolutional Neural Network
Authors: El Hamdi Dhekra , Elouedi Ines , Slim Ihsen
Published: July 2023

Lung cancer is the leading cause of cancer-related death worldwide. Therefore, early diagnosis remains essential to allow access to appropriate curative treatment strategies. This paper presents a novel approach to assess the ability of Positron Emission Tomography/Computed Tomography (PET/CT) images for the classification of lung cancer in association with artificial intelligence techniques. We have built, in this work, a multi output Convolutional Neural Network (CNN) as a tool to assist the staging of patients with lung cancer. The TNM staging system as well as histologic subtypes classification were adopted as a reference. The VGG 16 network is applied to the PET/CT images to extract the most relevant features from images. The obtained features are then transmitted to a three-branch classifier to specify Nodal (N), Tumor (T) and histologic subtypes classification. Experimental results demonstrated that our CNN model achieves good results in TN staging and histology classification. The proposed architecture classified the tumor size with a high accuracy of 0.94 and the area under the curve (AUC) of 0.97 when tested on the Lung-PET-CT-Dx dataset. It also has yielded high performance for N staging with an accuracy of 0.98. Besides, our approach has achieved better accuracy than state-of-the-art methods in histologic classification.
Exceptional Points and Exponential Sensitivity for Periodically Driven Lindblad Equations
Authors: Larson Jonas , Qvarfort Sofia
Published: July 2023

In this contribution to the memorial issue of Göran Lindblad, we investigate the periodically driven Lindblad equation for a two-level system. We analyze the system using both adiabatic diagonalization and numerical simulations of the time-evolution, as well as Floquet theory. Adiabatic diagonalization reveals the presence of exceptional points in the system, which depend on the system parameters. We show how the presence of these exceptional points affects the system evolution, leading to a rapid dephasing at these points and a staircase-like loss of coherence. This phenomenon can be experimentally observed by measuring, for example, the population inversion. We also observe that the presence of exceptional points seems to be related to which underlying Lie algebra the system supports. In the Floquet analysis, we map the time-dependent Liouvillian to a non-Hermitian Floquet Hamiltonian and analyze its spectrum. For weak decay rates, we find a Wannier-Stark ladder spectrum accompanied by corresponding Stark-localized eigenstates. For larger decay rates, the ladders begin to dissolve, and new, less localized states emerge. Additionally, their eigenvalues are exponentially sensitive to perturbations, similar to the skin effect found in certain non-Hermitian Hamiltonians.
An Enterprise View for Artificial Intelligence Capability and Governance: A System Dynamics Approach
Authors: Luna-Reyes Luis F. , Harrison Teresa M.
Published: July 2023

The government “enterprise” consists of a complex set of organizations with a multitude of goals and values, serving an equally diverse group of constituents. Because of this complexity, governing technology and data to support artificial intelligence (AI) capability has proven to be a difficult task that—according to experts—requires a systems perspective in its design and implementation. In this article, we take a conceptual approach to respond to this call from experts by providing working definitions of both enterprise data governance and a systems approach to management. Using these working definitions and data from municipal governments in Mexico, we develop a system dynamics model to explore some potential tradeoffs in the process of developing an enterprise view of information systems and data to create capability to develop AI applications in government. Simulation experiments suggest that an emphasis on governance of IT may create a strong foundation for the development of AI capability.
Global Health Interventions: The Military, the Magic Bullet, the Deterministic Model—and Intervention Otherwise
Authors: Yates-Doerr Emily , Carruth Lauren , Lasco Gideon , García-Meza Rosario
Published: July 2023

“Intervention” is central to global health, but the significance and effects of how intervention is practiced are often taken for granted. This review takes interventions into health and medicine as subjects for ethnographic inquiry. We highlight three lines of anthropological contributions: studies of global health interventions that serve imperial and military objectives, studies of “magic bullet” interventions arising from laboratory science, and studies of interventions based on deterministic modeling techniques. We then outline examples of “intervention otherwise,” in which people build relations of solidarity and care through global health programming, design interventions to be interactive and adaptable, and use data and modeling to support health justice. Whereas many global health interventions reproduce Western power hierarchies, intervention otherwise draws attention to alternative forms of knowledge, action, and expertise. Our analysis of lively and multivalent practices of intervention has implications for debates about the im/possibility of decolonizing global health.
Mechanism of Electrochemically Assisted Friction and Wear Behavior of GaN in KMnO4 Slurry
Authors: Zheng Qiongbin , Pan Jisheng , Zhou Rui , Zhuo Zhijia , Yan Qiusheng
Published: July 2023

Electrochemically assisted friction and wear behavior of gallium nitride (GaN) in a KMnO4 slurry was investigated to optimize the composition of the chemical mechanical polishing (CMP) slurry, and the material removal effect of GaN was visually evaluated by using the coefficient of friction (COF) curve and wear area. The results showed that the surface oxidation of GaN was effectively enhanced by KMnO4 and electrochemical assistance. The average COF and wear area of GaN increased with stronger oxidation of the environmental media, which improved the removal of the GaN surface material. Under acidic conditions, the oxidation of KMnO4 for GaN surface was significantly stronger than that under neutral and alkaline conditions, and the GaN surface was effectively oxidized and corroded when the initial mass fraction of KMnO4 was 5 wt%. When the chemical and mechanical actions reached a synergistic effect, the oxide layer generated on the GaN surface was immediately removed by the Si3N4 ball and SiO2 abrasive, which led to a large increase in material removal rate (MMR); the COF curve tended to stabilize, and the average COF increased. The experimental results of the electrochemically assisted CMP of GaN were consistent with the friction and wear test results.
Supplementary Table S1 from Cancer Epidemiology in the Northeastern United States (2013-2017)
Authors: Rees Judy R , Weiss Julie E , Gunn Christine M , Carlos Heather A , Dragnev Nathalie C , Supattapone Emma Y , Tosteson Anna N.A. , Kraft Sally A , Vahdat Linda T , Peacock Janet L
Published: July 2023

Data Quality criteria at 24 months, by state and diagnosis year, 2013-2017
Supplementary Video 2B from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Video 2B shows representative images of a Sulfasalazine-treated spheroid. Scale bar: 200 µm, number at top left: days post-implantation.
Data from Cancer Epidemiology in the Northeastern United States (2013–2017)
Authors: Rees Judy R. , Weiss Julie E. , Gunn Christine M. , Carlos Heather A. , Dragnev Nathalie C. , Supattapone Emma Y. , Tosteson Anna N.A. , Kraft Sally A. , Vahdat Linda T. , Peacock Janet L.
Published: July 2023

We tested the hypotheses that adult cancer incidence and mortality in the Northeast region and in Northern New England (NNE) were different than the rest of the United States, and described other related cancer metrics and risk factor prevalence. Using national, publicly available cancer registry data, we compared cancer incidence and mortality in the Northeast region with the United States and NNE with the United States overall and by race/ethnicity, using age-standardized cancer incidence and rate ratios (RR). Compared with the United States, age-adjusted cancer incidence in adults of all races combined was higher in the Northeast (RR, 1.07; 95% confidence interval [CI] 1.07–1.08) and in NNE (RR 1.06; CI 1.05–1.07). However compared with the United States, mortality was lower in the Northeast (RR, 0.98; CI 0.98–0.98) but higher in NNE (RR, 1.05; CI 1.03–1.06). Mortality in NNE was higher than the United States for cancers of the brain (RR, 1.16; CI 1.07–1.26), uterus (RR, 1.32; CI 1.14–1.52), esophagus (RR, 1.36; CI 1.26–1.47), lung (RR, 1.12; CI 1.09–1.15), bladder (RR, 1.23; CI 1.14–1.33), and melanoma (RR, 1.13; CI 1.01–1.27). Significantly higher overall cancer incidence was seen in the Northeast than the United States in all race/ethnicity subgroups except Native American/Alaska Natives (RR, 0.68; CI 0.64–0.72).

In conclusion, NNE has higher cancer incidence and mortality than the United States, a pattern that contrasts with the Northeast region, which has lower cancer mortality overall than the United States despite higher incidence.
Significance:
These findings highlight the need to identify the causes of higher cancer incidence in the Northeast and the excess cancer mortality in NNE.
Targeted Single-cell Isolation of Spontaneously Escaping Live Melanoma Cells for Comparative Transcriptomics
Authors: Tearle Jacqueline L.E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Solid cancer cells escape the primary tumor mass by transitioning from an epithelial-like state to an invasive migratory state. As they escape, metastatic cancer cells employ interchangeable modes of invasion, transitioning between fibroblast-like mesenchymal movement to amoeboid migration, where cells display a rounded morphology and navigate the extracellular matrix in a protease-independent manner. However, the gene transcripts that orchestrate the switch between epithelial, mesenchymal, and amoeboid states remain incompletely mapped, mainly due to a lack of methodologies that allow the direct comparison of the transcriptomes of spontaneously invasive cancer cells in distinct migratory states. Here, we report a novel single-cell isolation technique that provides detailed three-dimensional data on melanoma growth and invasion, and enables the isolation of live, spontaneously invasive cancer cells with distinct morphologies and invasion parameters. Via the expression of a photoconvertible fluorescent protein, compact epithelial-like cells at the periphery of a melanoma mass, elongated cells in the process of leaving the mass, and rounded amoeboid cells invading away from the mass were tagged, isolated, and subjected to single-cell RNA sequencing. A total of 462 differentially expressed genes were identified, from which two candidate proteins were selected for further pharmacologic perturbation, yielding striking effects on tumor escape and invasion, in line with the predictions from the transcriptomics data. This work describes a novel, adaptable, and readily implementable method for the analysis of the earliest phases of tumor escape and metastasis, and its application to the identification of genes underpinning the invasiveness of malignant melanoma.

Significance:

This work describes a readily implementable method that allows for the isolation of individual live tumor cells of interest for downstream analyses, and provides the single-cell transcriptomes of melanoma cells at distinct invasive states, both of which open avenues for in-depth investigations into the transcriptional regulation of the earliest phases of metastasis.
Gilda de Mello e Souza e a filosofia autoral no Brasil
Authors: Ramos Silvana de Souza
Published: July 2023

O presente artigo se organiza a partir de questões que procuram circunscrever o problema da autoria filosófica no Brasil. Procuro salientar que esse tema se aguça após o movimento da Primavera das Filósofas, impulsionado pelas discussões levantadas por diversas pesquisadoras durante o XVII Encontro Nacional da Anpof (Associação Nacional de Pós-Graduação em Filosofia), realizado em Aracaju, de 17 a 21 de outubro de 2016. Nesse evento, Carolina Araújo fez uma pergunta crucial à comunidade filosófica: quantas filósofas? Hoje, em meio à persistente efervescência dos debates feministas na área, as questões relativas à filosofia brasileira permitem-me trazer à luz a relevância do pensamento original de Gilda de Mello e Souza.
A trajetória de uma filósofa: Maria das Graças de Souza
Authors: Freitas Jacira de , Aranovich Patrícia Fontoura
Published: July 2023

O percurso acadêmico da Profa. Dra. Maria das Graças de Souza é aqui apresentado sob duas formulações que se entrelaçam: uma discussão sobre seus textos teóricos e a apresentação de suas atividades, no decorrer da carreira acadêmica. A primeira parte, intitulada: “O percurso intelectual: a articulação entre História, Política e ação política”, escrita por Jacira de Freitas, discute as ideias essenciais da produção teórica da filósofa, e defende a hipótese de que nela se reflete um pensamento que articula a História, a Política e a ação política, evidenciando a preocupação em conciliar a teoria e a prática, algo que reaparece em sua atuação como professora, mas se exprime sobretudo no âmbito de seus estudos. A segunda parte do texto, intitulada “A trajetória de uma professora”, escrita por Patrícia Aranovich, debruça-se sobre as atividades desenvolvidas como professora do Departamento de Filosofia da USP, e em suas interações com os Grupos de Estudo e Grupos de Pesquisa em todo o país, assim como com seus orientandos, alunos, amigos e colegas.
A ciência que sonha e o verso que investiga: o filosofar erótico de Olgária Matos
Authors: Bretas Aléxia
Published: July 2023

Olgária Chain Féres Matos é professora titular aposentada pelo Departamento de Filosofia da Universidade de São Paulo e professora titular no Departamento de Filosofia da Universidade Federal de São Paulo. Sua trajetória tem início em fins dos anos 1960, quando ingressa como estudante na Faculdade de Filosofia, Ciências e Letras da Universidade de São Paulo, então situada à rua Maria Antonia. Rousseau, Marcuse, Adorno, Derrida e principalmente Walter Benjamin são algumas de suas referências filosóficas mais importantes, a partir das quais a filósofa compõe uma constelação de ideias animadas pelo afeto e pelo erótico. Tendo a utopia como bússola, o desvio como método e a astúcia como guia, seu esforço constantemente renovado é o de iluminar os clássicos com a potência do efêmero e o brilho questionador do extemporâneo.
A condição epistêmica para a responsabilidade moral como uma forma de manutenção de estruturas de opressão
Authors: Marques Beatriz Sorrentino
Published: July 2023

Ao pensar as condições de adequação para a responsabilização moral, Michelle Ciurria não discute se o agente tem controle da ação. Ela propõe que a vítima seja trazida para o centro da discussão e questiona até mesmo a ideia de que a ignorância moral do agente impede a atribuição de culpa em alguns casos. Esse desafio à condição epistêmica pode dar origem a objeções. Por isso, proponho explicar por que essa condição não é importante se levarmos a proposta de Ciurria a sério, e como a influência dos esquemas de gênero na sensação de agência ajuda a mostrar isso.
O século XVII e o debate contra a misoginia: história, violência e resistência
Authors: Lacerda Tessa Moura
Published: July 2023

Trata-se de refletir sobre o apagamento do nome das filósofas na narrativa canônica da Filosofia do século XVII. Essa opressão de gênero faz parte de um conjunto mais amplo de opressões derivadas da organização do capitalismo naquele momento. A chamada “querela das mulheres” (querelle des femmes), debate entre feministas e misóginos iniciado no século XV, mas reforçado no XVII, evidencia as opressões de gênero, mas deve ser posto em relação com a violência colonial que caracterizou o século XVII. A resistência contra essas violências pode ser justamente uma filosofia da violência, tal como pensada pela filósofa Elsa Dorlin.
A lembrança que trago de Gilda, uma entrevista com Marilena Chaui
Authors: Chaui Marilena , Ramos Silvana de Souza
Published: July 2023

Entrevista de Marilena Chaui conce­dida a Silvana de Souza Ramos, no dia 08 de setembro de 2022, nas dependências do Instituto de Estudos Brasileiros (IEB/USP), instituição que abriga o Fundo Gilda de Mello e Souza.
Sobre a Natureza Humana
Authors: Lucânia Aesara de , Araújo Carolina
Published: July 2023

Tradução de Sobre a Natureza Humana, um texto em dialeto dórico transmitido unicamente por Estobeu (Eclogarum, I. 49.27) e atribuído a Aesara de Lucânia, pitagórico.
The Predictive Role of Hematological Parameters in Hypertension
Authors: Meng Xiangzhu , Sun Hong , Tu Xiaowen , Li Wei
Published: July 2023

Hypertension (HT) is a common chronic disease that often causes target-organ damage and severe complications, contributing to cardiovascular morbidity and mortality worldwide. Accumulating evidence suggests that inflammation plays a prominent role in the initiation and progression of HT. Multiple inflammatory biomarkers have been proposed to predict HT. Several new hematological parameters can reflect the inflammatory response and platelet activation. The major advantage of hematological parameters over conventional inflammatory markers is that they are relatively inexpensive and easily obtained from routine blood tests. Numerous studies have investigated several hematological parameters for their utility as predictive biomarkers for the diagnosis and prognosis of HT. Among them, the neutrophil to lymphocyte ratio (NLR), monocyte to high density lipoprotein cholesterol ratio (MHR), red cell distribution width (RDW), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and systemic immune-inflammation index (SII) have recently received attention. We searched PubMed and Embase databases (up to September 18, 2022) to assess the relationships between hematological parameters and HT. This review discusses the diagnostic and prognostic value of these hematological parameters in HT, providing an important basis for early screening, risk stratification, and optimal management of hypertensive patients.
“Now I Must Go”: Uncovering the Relationship Between Masculinity and Structural Vulnerability in Young African Men's Stories of Forced Migration
Authors: Palillo Marco
Published: July 2023

Drawing on personal narratives collected from Sub-Saharan African international protection holders and seekers in Sicily, this article aims to advance understanding of the gender-specific processes prompting young men to migrate toward Europe. Focusing on the diverse experiences of (or threat of) violence that prompted participants to migrate, I argue that masculinity can be seen as a mediating factor between the individual and structural levels, producing a set of structural vulnerabilities to male-on-male violence both in the public sphere and in private spaces like the familial context. Here, vulnerability should be understood as positionality, indicating participants’ placement within context-specific masculine hierarchies along the lines of age, migration status, and race. Accordingly, this article interprets the Central Mediterranean migration route as a highly masculinized migration arena, where the social reproduction of vulnerable male mobilities stemming from the hierarchical organization of masculinities is located on a continuum across different migration phases.
Finance interrupted: Social impact bonds, spatial politics, and the limits of financial innovation in the social sector
Authors: Williams James W
Published: July 2023

An enduring legacy of the 2007–2009 financial crisis is the growth of “social” and “impact” investing, markets dedicated to the use of financial capital to achieve social good. This paper examines one key manifestation of these markets: the social impact bond, a financial device which uses private capital to fund social programs. While social impact bond (SIBs) have been viewed as a testament to the power of finance and the “financialization” of the social sector, the paper instead highlights the struggles and limits of the SIB enterprise. Informed by a multi-year study of SIBs in Canada, the USA, and UK, and the theoretical lens of the social studies of assetization combined with an ecological approach, these struggles are conceived in terms of the challenge of operationalizing SIBs’ financial imaginary and managing the gaps between finance and the social sector as distinct ecologies. Particular emphasis is placed on three valuation devices—liquidity, risk, and rigor—which are central to this effort. Rather than “hinges” connecting these worlds, these devices have emerged as points of conflict, revealing a distinctly spatial politics which helps to explain the limits not only of SIBs but also other forms of financialization at the frontiers of (social) finance.
Examining ideology and agency within intensive motherhood literature
Authors: Autret Maya , van Eeden-Moorefield Brad , Lee Soyoung , Khaw Lyndal
Published: July 2023

In exploring why American mothers spend more time on care work compared to prior decades while increasingly engaging in paid work, Hays (1997) attributed women's actions to intensive motherhood (IM) ideology. Hays also asserted that women purposedly adhere to IM to resist an increasingly neoliberal market-based society by dedicating time and effort to nurturing children and family life. Here, we undertake a content analysis to take stock of IM literature's evolution in recent decades. Specifically, we examine scholars’ treatment of how women adhere to IM, and why and whether women do so in resistance to neoliberalism. We found that while scholars consistently cite and echo Hays (1997) on how women adhere to IM, most depart from Hays (1997) by positing women adhere to live up to an ideal of being a perfect mother due to the pervasive nature of IM. We also found many scholars focus on the possibility of resisting IM ideology itself rather than Hays’s (1997) perspective that women employ the ideology to resist neoliberalism. These findings raise questions about how women's agency manifests in the IM context, and concerns about embedded assumptions that limit our understanding of women's realities. Implications are discussed.
Dynamics of Trade Agreements, Trade and Investment in South, Southeast and East Asia
Authors: Manocha Rinku
Published: July 2023

South, Southeast and East (S, SE and E) Asian economies comprise a number of emerging economies that are significantly contributing to the world market. Asian economies are coming up with strong policy frameworks to strengthen trade and investment. Simultaneously, Asian economies (S, SE and E regions) are strategically negotiating a number of vital intra-regional as well as extra-regional trade agreements (RTAs) with an intent to not only boost trade but also to provide an environment for investors to stimulate foreign direct investment (FDI) flows. The study examined the trends and dynamics of regional integration, trade and investment in the said Asian region. The trend for RTAs indicates that economies in S, SE and E Asian regions have negotiated a significant number of bilateral and plurilateral trade agreements. Moreover, export values of three significant RTAs (Association of Southeast Asian Nations [ASEAN], Asia Pacific Trade Agreement [APTA], and South Asian Association for Regional Cooperation [SAARC] trading bloc) in the region suggest that export performance of ASEAN and APTA vis-à-vis intra-bloc and the world at large has been far better than the SAARC trading bloc. The dynamics of trade and investment suggest that East Asian economies are contributing a significant percentage to world trade and investment, and Southeast Asian economies are slowly improving trade and investment trends. However, Southern Asian economies need to revisit and revamp existing trade and investment policies to gear up trade and investment flows.
A Systematic Review with Bibliometric Analysis on Human Resource Information System (HRIS) with Reference to Service Sector
Authors: Boro Moneswari , Sharma L. S.
Published: July 2023

The human resource information system (HRIS) has played a significant role in promoting effective organisational learning, increased productivity, and sustainability during a time of demanding and evolving human resource management practices, as well as the development of information technology. This study combines a bibliometric analysis and a systematic literature review (SLR) to examine the topic. The systematic review was conducted in a methodical manner, involving the collection of available materials and their evaluation based on established criteria. The study focuses on articles published between 2001 and 2021, specifically from the Scopus database. To identify relevant articles, specific keywords such as ‘hris’, ‘hrms’, ‘human resource information system’ and ‘human resource management system’ were used. A total of 57 articles were included for further study based on predetermined inclusion and exclusion criteria. The purpose of this review-based work is to provide a qualitative understanding of the overall evolutionary trend, knowledge structure and literature gaps related to HRIS. It also suggests potential areas for future research, with a particular emphasis on the service sector, utilising open-source software. The findings highlight the benefits of implementing HRIS in the service sector and offer a comprehensive overview of the advancements and diversification of publications and research in this field. Additionally, the study provides scholars and practitioners with valuable insights to implement HRIS in various sustainable sectors.
“Strategic Application of Anatomical Subunit Approximation Technique for Correction of Complete Unilateral Cleft lip”
Authors: Moon Jeehyun , Bae Juyoung , Lim So Young
Published: July 2023

Objective

To discuss advantages, disadvantages and strategical application of anatomical subunit approximation technique in complete unilateral cleft lip repair.

Design

Analysis of consecutive 28 cases.

Setting

A single surgeon experience at a university hospital.

Patients

Among 77 patients who underwent cleft lip repair between May 5, 2019 and June 30, 2021, 28 patients with complete unilateral cleft lip who received cheiloplasty by author's technique.

Main Outcome Measures

Surgical outcomes were assessed by frontal view medical photographs obtained postoperatively at follow-up visits.

Results

The average length difference between cleft and noncleft sides was <10% for transverse lip length and philtral height. Nostril sill height demonstrated about twenty percent of difference with much variable results. Although the one sample t-test revealed that differences exist between the cleft and noncleft side, they were within an acceptable range.

Conclusions

Understanding the strengths and limitations of anatomical subunit approximation technique enabled strategic application in complete unilateral cleft lip repair. Satisfactory outcomes were achieved not only regarding the scar placement but also regarding the symmetry of the lips and augmentation of nasal sill.
Tomographic Evaluation of the Upper Cervical Spine in Patients with Cleft lip and Palate and Class III Malocclusion
Authors: Dias Ricardo Correa da Costa , Marzano Rodrigues Maria Noel , Trindade-Suedam Ivy Kiemle , Trindade Sergio Henrique Kiemle
Published: July 2023

Objective

To perform a morphometric analysis of the upper cervical spine (UCS) by means of cone-beam computed tomography (CBCT) for the diagnosis of malformations or craniocervical instabilities in patients with cleft lip and palate (CLP) and class III malocclusion.

Materials and Methods

A total of 72 CBCTs from adult patients (48 male and 24 female) with Angle Class III malocclusion were divided into three groups: 1) Unilateral cleft lip and palate (UCLP) (n = 29; male = 65.5%; age = 24, 2 ± 4.2 years); 2) Bilateral cleft lip and palate (BCLP) (n = 18; male = 83.3%; age = 26.4 ± 6.0 years); 3) Control group (CON) (n = 25; male = 56.0%; age = 27.8 ± 9.3 years). The version 11.7 of the Dolphin® software (Chatsworth, California, USA) was used to evaluate the morphometric measurements and anomalies of the UCS. Data were analyzed by descriptive and inferential statistics (p ≤ 0.05).

Results

For the UCLP, BCLP and CON groups, respectively, the measures were: atlantodental interval (2.1 ± 0.5; 2.1 ± 0.4; 2.0 ± 0.3 mm), basion-opisthion (35.9 ± 3.2; 36.4 ± 3.0; 34.7 ± 1.9 mm), hyoid-C3 (34.5 ± 3.7; 34.5 ± 5.2; 35.3 ± 4.5 mm), and hyoid-sella (108.1 ± 9.8; 111.3 ± 9.2; 109.7 ± 10 mm); clivus-canal angle (152.3 ± 13; 150.3 ± 10; 150.7 ± 10°) and Torg-Pavlov index (1.0 ± 0.2; 1.0 ± 0.1; 1.1 ± 0.2). Potentially unstable anomalies and malformations were more prevalent in the UCLP group (34,4%).

Conclusion

Subjects with UCLP presented compressive or unstable anomalies on upper cervical spine, more frequently than controls and BCLP, despite the lack of statistically significant differences among groups. Future studies could increase the safety of patients and healthcare professionals specialized in craniofacial anomalies.
Erotic Feelings Towards Patients in the Psychotherapy Session: Investigating Their Relationship With the Characteristics of the Therapist, the Patient, and the Treatment
Authors: Stefana Alberto , Youngstrom Eric A.
Published: July 2023

Experiencing erotic feelings towards a patient is a fairly common occurrence, not pathological per se, during phases of psychotherapy. This study aims to analyze associations between, on the one hand, the presence in therapists of romantic attraction (RA), sexual attraction (SA), or flirting behavior (FB) toward patients and, on the other hand, a series of characteristics of therapist, patient, and treatment. Between April and June 2022, 547 psychotherapists completed an online survey investigating their affective and behavioral responses toward their most recently treated patient. Compared to female therapists, males showed significantly higher prevalence of SA alone ( p < .001) or in combination with RA ( p < .01), FB ( p < .01), or both ( p < .05). Multivariate adjusted regression models showed that RA was associated with patient age ≤40 years (OR:39.49 for age 18–29; OR:28.44 for age 30–39), male sex (OR:10.40), and diagnosis of mood disorder (OR:14.08). Furthermore, RA was associated with intense countertransference feelings of tenderness towards the patient (OR:79.77) and hostility towards significant figures in their life (OR: 77.93). SA was associated with the therapist’s male sex/gender (OR: 16.14), psychoanalytic orientation (OR:13.34), post-license experience ≤20 years (OR:6.12 for 1–9 years; OR:6.08 for 10–19 years). Lastly, FB was associated with the therapist’s male sex/gender (OR:16.94).
Disability Dates as Microgenre: 1990s Sitcoms and Backlash to the Americans with Disabilities Act
Authors: Ellcessor Elizabeth
Published: July 2023

This article performs a historical corrective, documenting representations of disability in popular U.S. television sitcoms of the 1990s. While these shows did not center disability, they often featured strikingly similar episodic narratives involving disability, using the framework of romantic dates with a main character. This article analyzes these episodes as a microgenre, referred to as “disability dates.” This microgenre represents a fleeting subgenre of the sitcom that used similar strategies to represent disability and to reproduce popular discourses that opposed or undermined the Americans with Disabilities Act (1990).
The case for and Against Doing Virtual Photovoice
Authors: Oliffe John L. , Gao Nina , Kelly Mary T. , Fernandez Calvin C. , Salavati Hooman , Sha Matthew , Seidler Zac E. , Rice Simon M.
Published: July 2023

Photovoice offers creative participatory action methods for conveying community strengths and challenges with the goal of addressing health inequities. Accelerated by COVID-19 restrictions, photovoice has increasingly become virtual, and this shift has given rise to new considerations including navigating online recruitment and data collection, e-participatory action trends and working with multi-site large qualitative data sets. Within these contexts, the current article discusses the case for and against virtual photovoice, drawing from a large study comprising 110 men’s experiences of, and perspectives about, equitable and sustainable intimate partner relationships. The findings are shared across three themes. The first theme, e-Efficiencies and concessions contrasts increased recruitment reach and data collection cost-savings with vulnerabilities to phishing and challenges for working with participants’ wide-ranging internet literacies and practices. Theme two, Participatory action changed, chronicles the participants’ varied relationships to photography including sourcing third-party and archived photographs. Revealed also were privacy concerns whereby some participants opted for audio only interviews and/or restricted the use of their photographs. The third theme, Reckoning breadth and depth in a large dataset, discusses emergent study design considerations including analytics for interpreting and contextually representing large multi-site projects that are made possible through virtual photovoice. While technological advances and COVID-19 have forged photovoice virtually, the case for and against this trend reveals complex considerations that will likely manifest a continuum of approaches ranging virtual, hybrid and in-person models. In summary, we suggest that integral to weighing the case for and against virtual photovoice researchers will need to thoughtfully adapt to changing technologies, as well as potential post COVID-19 tilts for returning to in-person.