bluuebunny/crossref_metadata_2025 huggingface dataset:
Ouro e lágrimas de Maria Moura: uma heroína contemporânea no sertão do século XIX
Authors: Moretzsohn Patrícia Coelho
Published: March 2021

Quais seriam as características de uma heroína de folhetim do século XXI? O folhetim do século XIX trouxe para o papel muitas das estratégias do melodrama teatral, surgido na França após a Revolução Francesa. Por meio do romance, ou da novela de folhetim, o melodrama dá o salto final necessário para ser identificado com os meios de comunicação de massa. O surgimento da novela de folhetim foi um fator determinante na evolução do melodrama e o antecedente mais remoto de uma das articulações básicas do desenvolvimento da indústria cinematográfica: o valor do produto segundo a demanda do mercado. Ao longo da História, melodrama e folhetim confundiram-se para assumir as mais diversas formas segundo a tecnologia vigente em cada época. Hoje, sua residência mais natural parece ser a televisão, mas será que nada mudou em sua estrutura? Maria Moura, personagem de romance de Rachel de Queiroz e de minissérie televisiva, traz um novo arquétipo para o folhetim: o da matriarca, e talvez aponte para novas características do que seria uma heroína contemporânea.
The trade-off between chain performance and fragility considering coordination strategies of agri-food chains: a South African egg chain’s case study
Authors: Setene Letlama , du P.S. Jordaan Daniel
Published: March 2021

The mainstream strategy in the coordination of agri-food chains has traditionally focused more on the enhancement of chain performance by adopting lean and highly integrated strategies. These strategies are premised on the principle that governance structures are the result of tactics that economize on transaction costs in exchanges in chains. Due to existing interdependencies between chain players such strategies expose these chains to detrimentally disruptive uncertainty. This paper adopted a heuristic stress-testing approach to measure the fragility of South African egg value chain and performed a comparative fragility analysis of two coordination approaches in the egg chain. Additionally, the analysis of results indicated that the egg chain strategy with high levels of interdependencies between its chain players as significantly fragile. Precisely, the difference between the chain strategies was associated with a variety of differences at the factor and chain player levels that led up to a higher overall chain fragility of the chain with higher levels of interdependency. Inevitably, the paper propositions that there is a trade-off between chain performance and fragility. The results of the study affirmed that there is a trade-off between chain performance and fragility which needs to be balanced.
What links neuroscience to agricultural economics? A review of neuroscientific methods literature in agricultural economic research and marketing
Authors: Schukat Sirkka , Diekmann Marie , Heise Heinke
Published: March 2021

Research into consumer behavior is confronted with a multitude of challenges and special features. These become apparent in economic decision-making situations in which actual behavior deviates massively from rational explanatory models, such as the model of homo economicus, or when discrepancies are observed between statements made by individuals and their actions. As a common intersection between the economic and the neurosciences, neuroeconomics investigates human decision-making behavior from a neuroscientific perspective. The focus is particularly on explaining these antagonisms of human behavior and deriving motives. With the help of this potentially expandable knowledge, it is possible to subtly influence individual purchasing decisions at the neural level and to predict consumer behavior at the market level. In agricultural economics, for example in the field of food marketing, neuroeconomics could contribute to more reflective purchasing decisions and thus counteract global health challenges such as obesity. To date, no research has been conducted into the extent to which neuroeconomics has already been applied in agricultural scientific research. The objectives of the article are to provide an aggregated basic knowledge in the field of neuroeconomics, taking into account the applied methods as well as a literary overview of previous research in the context of agricultural economics. The article addresses all those interested in getting an overview of what neuroeconomics entails and how it is already being applied in agricultural research without any prior neuroscience background.
Efficacy of hemoadsorption using HA330-II perfusion column in secondary HLH patients: two cases report and literature review.
Authors: Gao Qian , Zhao Chun , Wang Yujuan , Wang Wei , Yin Yi , Xin Xiaowei , Wang Xiaoru , Jin Youpeng
Published: March 2021

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a severe and
potentially lethal disorder characterized by overwhelming immune
activation and inflammation. Several blood purification methods have
been reported to be successfully practiced as adjuvant therapy for
hypercytokinamia complicated with HLH. We firstly reported two cases of
secondary HLH children received hemoadsorption therapy with HA330-II
perfusion cartridge combined with CVVHDF. The marked decrease in IL-6
plasma levels and stabilization of organ function were observed after
treatment, which proved the efficiency of HA330-II perfusion column.
Keywords: hemoadsorption, blood purification, Hemophagocytic
lymphohistiocytosis, pediatric
The importance of social values in the prioritization of research: a quantitative example and generalizations
Authors: Falcy Matt
Published: March 2021

1. Identifying critical uncertainties about ecological systems can help
prioritize research efforts intended to inform management decisions.
However, exclusively focusing on the ecological system neglects the
objectives of natural resource managers and the associated social values
tied to risks and rewards of actions. 2. I demonstrate how to prioritize
research efforts for a harvested population by applying expected value
of perfect information (EVPI) analysis to a matrix projection model of
steelhead (Oncorhynchus mykiss) and an explicit utility function that
models risk/reward objectives. Research priorities identified by EVPI
diverge from priorities identified by matrix elasticity analyses that
ignore utility. The degree of divergence depends on uncertainty in
population vital rates and the particular form of the utility function
used to represent risk/reward of harvest. 3. Synthesis and applications.
EVPI analysis that includes perceived utility of different outcomes
should be used by managers seeking to optimize monitoring and research
spending. Collaboration between applied ecologists and social scientists
that quantitatively measure peoples’ values is needed in many structured
decision making processes.
Surgical removal of an exceedingly rare papillary fibroelastoma of the aortic wall causing unstable angina
Authors: Masiello Paolo , Catalano Angelo , Mastrogiovanni Generoso , Eusebio Geppina , Roberto Anna Maria De , Chivasso Pierpaolo , Ciancia Giuseppe , Iesu Ivana , Triggiani Donato , Iesu Severino
Published: March 2021

Papillary fibroelastomes are rare benign neoformations usually
originating from the valvular endocardium, presenting with cerebral
ischemia and/or myocardial infarction due to embolization from the mass.
We report an exceedingly rare case of aortic wall papillary
fibroelastoma simulating unstable angina, diagnosed with
trans-thoracic/trans-esophageal echocardiography and CT scan and
surgically successfully removed
Specific High-sensitivity Multiple-probe-assisted DNA Capture and Amplification Technology for Direct Detection of African Swine Fever Virus without DNA Extraction
Authors: Wang Huicong , Pian Hongru , Fan Lihua , Li Jian , Yang Jifei , Zheng Zhi
Published: March 2021

African Swine Fever (ASF) is one of the most devastating infectious
diseases affecting domestic pigs and wild boar. The grave socio-economic
impact of African Swine Fever infection at a global level makes
large-scale rapid and robust diagnosis a critical step towards effective
control. However, the nucleic acid purification required in most
molecular detection methods is time- and labor-intensive, prone to
nucleic acid loss or contamination, and impractical for massive active
screening or for use in resource-limited areas. Here we describe
multiple-probe-assisted DNA capture and amplification technology
(MADCAT) - a novel sensitive, simple, and reliable method for detecting
ASFV directly from whole blood or other complex matrices. Through the
unique DNA capture method which specifically capture only the target DNA
onto the well for subsequent amplification, MADCAT abandons the
complicated extraction protocol and achieves ultrafast and
high-throughput detection. The sample-to-result time for 96 samples is
about 100 min, as compared with the 3 - 4 h time of the standard real
time qPCR method. The limit of detection (LOD) is 0.5 copies/μL and is
10 times more sensitive than an OIE-recommended qPCR assay when testing
serially diluted whole blood samples. The assay is 100% specific
against other common swine pathogens. In clinical diagnosis of 48 field
samples, all 22 positive samples were correctly identified with lower Ct
values than OIE-recommended qPCR, confirming its high diagnostic
sensitivity (100%). Owing to its high-throughput, specific
high-sensitivity, and cost-efficient features, MADCAT shows great
potential for future use in clinical ASFV active screening.
What contributes the most to the breast cancer patients’ quality of life during the therapy - clinical factors, functional and affective state or social support?
Authors: Novakov Ivana , Popovic-Petrovic Svetlana , Ilincic-Zlatar Sonja , Tatic Milanka , Sevo Mirjana
Published: March 2021

Background/Aim. As significant advances in cancer treatment have occurred over the past decades, the crucial questions in oncology nowadays are not related only to the treatment of the illness but also to the quality of life (QOL) of patients. The aim of our study was to explore which set of determinants (clinical, functional, affective, or social) has the greatest impact on explaining QOL in women who live with the diagnosis of breast cancer. Methods. The research was conducted on 64 women (with a mean age of 58.36 ? 11.30) while undergoing radiation therapy at the Oncology Institute of Vojvodina, Serbia. Quality of Life Instrument ? Breast Cancer Patient Version (QOL-BC) questionnaire was used for evaluation of physical, psychological, social, spiritual, and general well-being, the Upper Extremity Functional Index (UEFI) was applied for the assessment of the upper extremity function, the Depression, Anxiety, and Stress Scale-21 Items (DASS-21) was used for measuring symptoms of depression, anxiety, and stress, the Medical Outcomes Survey, Social Support Survey (MOS-SSS) served for evaluation of social support; demographic and clinical data of patients were also collected. Results. Analysis of Variance (ANOVA) with repeated measures [F(2.03, 127.80) = 20.24, p < 0.001] showed that in our sample, physical QOL was significantly better from all other domains, while social QOL was significantly lower from both physical and psychological aspect. A hierarchical regression analysis [F(8, 55) = 7.16, p < 0.001, R2 = 0.51] showed that patients who received adjuvant chemotherapy and experienced high levels of stress and poor social support usually had diminished general QOL. Introduction of affective-related variables [?R2 = 0.16, p(?F) < 0.01] and social support [?R2 = 0.05, p(?F) < 0.05] led to a significant increase in proportion of explained variance over and above the clinical and functional variables. Conclusion. Our results indicate that psychological and social resources are more important in predicting QOL compared to clinical and functional factors. At the same time, the social, psychological, and spiritual well-being of patients is significantly worse compared to the physical QOL, meaning that there is still much left to be done regarding the progress from a purely somatic to a holistic approach in the treatment of breast cancer.
The use of a single pass albumin dialysis for the management of liver failure
Authors: Azasevac Tijana , Knezevic Violeta , Celic Dejan , Ljubicic Bojana , Lakic Tanja , Mitic Igor
Published: March 2021

Introduction. A single pass albumin dialysis (SPAD) is a form of extracorporeal liver support system for removing albumin-bound toxins and water-soluble substances that accumulate in liver failure (LF). Case report. We presented three patients hospitalized for LF and treated using the SPAD at the University Clinical Center of Vojvodina, Serbia, from 2018 to 2019. Two of the patients presented with acute LF and one with acute-on-chronic LF. A total of 6 SPAD sessions were performed on each patient, resulting in decreased serum bilirubin and bile acid levels and hepatic encephalopathy grade. On discharge from the hospital, the liver function was improved in all the patients. Conclusion. SPAD removes the hepatotoxic substances without improvement of synthetic liver function. It represents a supportive treatment for LF patients who do not respond to the standard of care, offering a longer time for bridging to organ transplantation or spontaneous recovery of the liver function.
The role of c-MYC expression in the diagnostic and clinical confirmation of radiation-induced angiosarcoma
Authors: Jovanovic Luka , Filipovic Predrag , Dedovic-Stojakovic Jelena , Milovanovic Zorka , Labudovic-Borovic Milica , Tanasijevic Jasminka , Petrasinovic Predrag , Marinkovic Tamara , Plesinac-Karapandzic Vesna
Published: March 2021

Introduction. Angiosarcomas (ASs) arising from vascular tissue, account for 3.3% of all sarcomas and have a poor prognosis. Radiation-induced AS is a rare late complication of radiotherapy (RT) treatment and is characterized by a gene expression profile such as amplification of the MYC oncogene, by which we can distinguish primary from secondary induced tumor. Case report. For a 77-year-old female patient with early-stage endometrial adenocarcinoma, a radical hysterectomy with bilateral salpingo-oophorectomy was initially done. According to pathological risk factors, the postoperative external beam conformal RT (CRT) of the pelvis was administered with concomitant brachytherapy. Six years after the treatment, on the anterior abdominal wall, in the region of the postoperative irradiation field and surgical scar, an infiltrative AS of the skin and subcutaneous adipose tissue was histologically confirmed. The patient received six cycles of mono-adriamycin chemotherapy with verified partial regression. Additional immunohistochemical analysis (IHC) of c-MYC, Ki67, and CD34 expression showed a high proliferative index (Ki67 around 60%) and c-MYC positivity indicating the molecular pattern of radiation-induced AS. Furthermore, the high proliferative index could explain the positive response to chemotherapy. Conclusion. The novel postoperative RT techniques provide better survival and local control in risk-endometrial cancer groups with a decrease in irradiation complications. These patients with longer survival are at a higher risk of developing radiation-induced tumors as late side-effects of RT. When assessing the probability of radiation-induced AS, IHC analysis of c-MYC expression could distinguish secondary from other AS if Cahan?s criteria are fulfilled.
Correlation of neuropsychological indicators of child development with speech: Empirical research underpinning the National Children’s Health Prevention Programme
Authors: Otasevic Jadranka , Vukasinovic-Radojicic Zorica , Otasevic Bozidar
Published: March 2021

Background/Aim. Psychophysiological disorders and speech pathology is one of the priority public health problems in the Republic of Serbia. A child?s growth and development proceed in a particular sequence and course, depending on individual physiological capacities, quality of neuromuscular structures, and stimuli, which can be significantly affected by the environment. The development of speech from birth to the adult age is a result of the interaction of neurocognitive factors that contribute to the gradual attainment of phonological presentation and motor control abilities. The aim of the study was to examine the connection between manipulative manual dexterity, oral praxis, and lateralization with the development and speech in children and their potential for the development of prevention programs. Methods. The sample included 60 children from Belgrade of both sexes, aged between 5.5 and 7 years. Of these, 30 made up the experimental group ? children with deviations in speech development (articulation disorders), and 30 made up the control group ? typically developing children from the general population. The instruments used were the Manipulative Manual Dexterity Test (Lafayette), Oral Praxis Test, and part of the Test for assessing lateralization (auditory, visual, and functional). Results. The hand grip development level was statistically significantly different between the experimental and the control group (?2 = 21.40, df = 3, p < 0.01). The presence of associated involuntary movements statistically significantly differed between the experimental and the control group examinees (?2 = 10.58, df = 1, p < 0.01). Oral praxis statistically significantly differed between the experimental and the control group (t = 2.01, p < 0.05). Visual laterality statistically significantly differed (?2 = 7.56, p < 0.05) between the observed groups. When all predictors were taken into account, significant contribution to the explanation of the existence of speech pathology (articulation disorders) was given by the variables: Visual lateralization [odd ratio (OR) = 0.38; 95% confidence interval (CI) = 0.179?0.832; p = 0.015] and the level of hand grip development (OR = 0.23; 95% CI = 0.082?0.699; p = 0.009). Conclusion. The hand grip development level and visual laterality are worse in children with speech (articulation) impairment and developmental deviations. These indicators of child development should be used as a guide in designing the national programs for developmental assessment and prevention in the child healthcare system.
Myo-Inositol, Probiotics, and Micronutrient Supplementation From Preconception for Glycemia in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial
Authors: Godfrey Keith M , Barton Sheila J , El-Heis Sarah , Kenealy Timothy , Nield Heidi , Baker Philip N , Chong Yap Seng , Cutfield Wayne , Chan Shiao-Yng , Group NiPPeR Study
Published: March 2021

Objective: Better
preconception metabolic and nutritional health are hypothesized to promote
gestational normoglycemia and reduce preterm birth, but evidence supporting
improved outcomes with nutritional supplementation starting preconception is
limited.

Research Design
and Methods: Double-blind randomized controlled
trial recruited from the community 1729 UK, Singapore and New Zealand women
aged 18-38 years planning conception. We investigated if a nutritional
formulation containing
myo-inositol, probiotics and multiple micronutrients (intervention), compared
with a standard micronutrient supplement (control), taken preconception and
throughout pregnancy, could improve pregnancy outcomes. The primary
outcome was combined fasting, 1-hour and 2-hour post-load glycemia (28 weeks’
gestation oral
glucose tolerance test).

Results: Between
2015-2017, participants were randomized to control (n=859) or intervention
(n=870); 585 conceived within 1-year and completed the primary outcome (295
intervention, 290 control). In an intention-to-treat analysis adjusting for site, ethnicity and preconception glycemia
with pre-specified p<0.017 for multiplicity, there were no differences in
gestational fasting, 1-hour and 2-hour glycemia between groups (β [95%CI] loge mmol/L intervention versus control: -0·004 [-0·018, 0·011], 0·025 [-0·014, 0·064],
0·040 [0·004, 0·077], respectively). Between the intervention
and control groups there were no
significant differences in gestational diabetes (24·8% versus 22·6%, adjusted risk ratio aRR=1·22 [0·92, 1·62]), birthweight (adjusted β=0·05kg [-0·03, 0·13]), or gestational age at birth (mean 39.3 versus
39.2 weeks, adjusted β=0·20 [-0·06,
0·46]), but there were fewer preterm births (5·8% versus 9·2%, aRR=0·43 [0·22, 0·82]) adjusting for pre-specified
covariates.

Conclusions: Supplementation with
myo-inositol, probiotics and micronutrients preconception and in pregnancy did
not lower gestational glycemia, but did reduce preterm birth.
Scientific literacy changes the world. Science education recommendations.
Authors: The Committee for Public Information (TJNK)
Published: March 2021

Information processing skills are becoming all the more significant as traditional authorities of knowledge are challenged by media hubbub and false and misleading information. Critical thinking and the ability to interpret information flows and distinguish between relevant and irrelevant information are increasingly important civic competences.

Competent, critically thinking citizens build their lives and the society around them on reliable information. In addition to media literacy, we need scientific literacy.

Scientific literacy relies on science education. In Finland, science education is carried out by various actors from early childhood education to higher education, from nationwide networks to rural school science clubs, and from scientific societies to science journalists and non-fiction writers. Science education involves diverse activities and audiences, but they all share the same goal: to offer high-quality, lifelong science education.

The purpose of these science education recommendations is to provide a shared starting point and source of inspiration for all those engaged in science, learning and education. They can be summarised in five principles:

• Science education is accessible• Science education is broad-based• Science education enables participation• Science education is collective• Science education is inspiring and rewarding.

We also offer tips and ideas to provoke thought to support the implementation of these recommendations.

These science education recommendations have been drawn up by actors in the field and are meant for other actors in the field. The recommendations are the result of a project titled ‘An inquiry and recommendations to support scientific education (Selvitystyö ja suosituksia tiedekasvatuksen tueksi) jointly conducted by the Federation of Finnish Learned Societies and the Committee for Public Information and funded by the Ministry of Education and Culture. The project involved dozens of experts from the fields of education, training, research, arts and museums, scientific societies and liberal adult education.

Due to the coronavirus pandemic, our collaborative activities mainly took place online in 2020. Inevitably, the transfer into the virtual world and other changes in practices will also be manifested in the ways in which we carry out science education and science communication. We would like to warmly thank all the actors in the field of science education and the representativesof scientific societies who participated in our online workshops and contributed to the writing of these recommendations!
STUDY ON GC-MS PROFILE OF FUELS PRODUCED FROM PLASTIC WASTE CONVERSION VIA THREE-CONDENSER PYROLYSIS REACTOR
Authors: Bahri Syaiful , Ambarwati Yuli , Martin Yul , Marlina Lina , Waluyo Sri
Published: March 2021

The problem of plastic waste is very flourished in the current era of modern life.  In this study, a three-condenser pyrolysis reactor was applied to obtain fuels in the form of oil#1, oil#2, and oil#3 from plastic waste. Gas Chromatography-Mass Spectroscopy (GC-MS) technique was carried out to analyze the fuel for profiling study.  Characterization using GC-MS indicated the domination of hydrocarbon compounds was found oil#1.  The existence of hydrocarbon compounds from oil#2 and oil#3 was displayed by chromatogram and MS database from Library Wiley 7.LIB.  Meanwhile, alcohol, ether, and fatty acid were detected from oil#1 based on the chromatogram and MS database.  Therefore, the samples were categorized as fuel.  The result of this study corresponded to the concept of pyrolysis and be able to be implemented as an alternative energy source. Keywords: fuel, GC-MS profile, plastic waste, three-condenser pyrolysis reactor
APLIKASI LEAN SIX-SIGMA UNTUK MENGURANGI PEMBOROSAN DI BAGIAN PACKAGING SEMEN
Authors: Astuti Reni Dwi , Lathifurahman Lathifurahman
Published: March 2021

Hasil observasi di PT. Holcim Indonesia Tbk, pabrik Cilacap, didapati banyaknya pemborosan di bagian pengepakan semen, termasuk banyaknya produk cacat kemasan, sehingga banyak semen tercecer dan harus mengulangi proses pengepakan. Penelitian ini dilakukan untuk mengidentifikasi pemborosan selama proses pengepakan menggunakan  pendekatan lean manufacturing dengan value stream mapping. Sementara tingkat kualitas dianalisis dengan metode six-sigma. Penyebab kecacatan produk dianalisis dengan fish-bone diagram. Failure Mode and Effect Analysis (FMEA) digunakan untuk merancang ususlan perbaikan. Pemborosan yang teridentifikasi meliputi : transportation, motion, waiting, over processing, dan defect. Usulan perbaikan untuk mengurangi pemborosan yaitu dengan penggabungan stasiun penimbangan dan stasiun pemeriksaan, sehingga memberikan estimasi peningkatan  process cycle effisiensi  dari 39,1% menjadi 46,69. Sedangkan upaya untuk mengurangi cacat produk dilakukan dengan perawatan preventif mesin packer.
Pengaruh Pemberian ASI, Imunisasi, MP-ASI, Penyakit Ibu dan Anak terhadap Kejadian Stunting pada Balita
Authors: Rayhana Rayhana , Amalia Chairun Nisaa
Published: March 2021

Latar Belakang: kekurangan asupan gizi sejak lahir sampai balita dapat menyebabkan permasalahan kesehatan pada balita yaitu pertumbuhan tinggi badan yang tidak optimal (stunting). Pertumbuhan tinggi badan yang terhambat pada saat balita akan berakibat pada tingkat kecerdasan otak setelah dewasa. Tujuan: mengetahui faktor dominan yang mempengaruhi kejadian stunting pada balita di Puskesmas Cimuning Bekasi. Metode: penelitian menggunakan desain cross-sectional dilakukan di Puskesmas Cimuning Bekasi pada bulan Oktober-November 2019. Sampel diambil dengan teknik total sampling sebanyak 100 ibu-anak. Stunting diukur dengan antropometri menggunakan indikator tinggi badan menurut umur (TB/U). Variabel independen (pemberian ASI, imunisasi, MP-ASI, penyakit ibu dan anak) diukur menggunakan kuesioner. Analisis data menggunakan regresi logistik ganda. Hasil: kejadian stunting dialami oleh sebanyak 30,0% balita. Faktor dominan yang mempengaruhi kejadian stunting pada balita adalah pemberian ASI eksklusif. Kesimpulan: promosi pemberian ASI eksklusif harus diterapkan disetiap fasilitas kesehatan dan media sosial agar informasi tersebut sampai ke masyarakat luas sehingga dapat menurunkan angka kejadian stunting pada balita.
Revisión de los métodos de medición del rendimiento académico en los estudiantes universitarios
Authors: Acosta Jimenez Juan Carlos , Baldiris Navarro Ildelfonso
Published: March 2021

Las Instituciones de Educación Superior, son empresas que brindan servicios educativos, ofreciendo programas académicos a nivel tecnológico, universitario, de formación continua y posgrados, diseñados para atender necesidades sentidas del sector social y productivo, mediante un proceso integral. En el desarrollo del presente escrito, se realizó una revisión descriptiva sobre los distintos métodos estadísticos usados para determinar las causas que han generado el problema de deserción escolar y el bajo rendimiento académico de los estudiantes, lo cual proporciona al lector una puesta al día sobre conceptos y herramientas de gran interés, para establecer acciones de precaución y mejora continua en los procesos académicos de enseñanza aprendizaje.
Dimensiones estratégicas para el fortalecimiento de la responsabilidad social empresarial en Pymes del sector de la construcción en Colombia
Authors: Morelos Gómez José , García Díaz Hernando José , Prada Sánchez Mayra
Published: March 2021

Este artículo presenta una revisión de las dimensiones estratégicas para el fortalecimiento de políticas de responsabilidad social empresarial (RSE) en las Pymes del sector de la construcción en Colombia. La investigación fue de tipo descriptivo y explicativo, en la cual se aplicó instrumento estructurado in Situ a 45 Pymes seleccionadas del sector, para conocer el cumplimiento de lineamientos establecidos en la norma GTC-180, para los años 2017 y 2018. Como resultado, se encontró que aun cuando las empresas de estudio incluyen los conceptos de RSE en su organización, no califican y aplican todos los elementos valorados, respecto a los estándares establecidos por las instituciones que velan por el cumplimiento de los lineamientos de responsabilidad social establecidos.
APRENDIZAJE CONECTADO EN REDES SOCIALES
Authors: Santoveña Casal Sonia , López Susana Regina
Published: March 2021

En el marco del proyecto Análisis de pedagogías digitales: Comunicación, Redes Sociales y nuevas narrativas (CoReN) se ponen en marcha distintas propuestas pedagógicas digitales. En este artículo se presentan los resultados obtenidos en el desarrollo de un modelo de aprendizaje conectado en redes sociales. Se llevan a cabo varios debates académicos en Twitter en el marco de distintas asignaturas. Posteriormente, se evalúan los resultados obtenidos a través del desarrollo de diferentes grupos de discusión realizados con los estudiantes. El análisis de datos es cualitativo, basado en el análisis de contenido de los grupos de discusión. Los resultados indican que los estudiantes valoran muy positivamente la puesta en marcha de propuestas innovadoras en los estudios oficiales. Se concluye que la participación de carácter académico a través de Twitter ha mejorado el proceso comunicación e interacción y también el aprendizaje de los estudiantes.
Achievement goal orientations and perceived physical competence profiles in adolescent physical activity
Authors: Nicolosi Simona , Ortega Ruiz Rosario , Benitez Sillero Juan de Dios
Published: March 2021

The objective of this study was to analyze the relationships between achievement goals and perceived physical competence in a sample of 4493 adolescents between 12 and 18 years of age (M=14.92, SD=2.08). A cluster analysis was performed to (1) identify cluster profiles of the adolescents based on their goal orientations and perceived physical competence, and (2) assess whether clusters differed in gender, age, and participation in physical activity. Three stable clusters reflecting different achievement goals and perceived physical competence profiles were identified: high, moderate, and low task orientation and perceived competence. Differences were found in genders, age, and physical activity frequency. The discussion focuses on the implications for educators, physical education teachers, and coaches and provides information for possible strategies to foster physical activity in adolescents.
Prevalencia del sexting en adultos jóvenes universitarios: motivación y percepción del riesgo
Authors: Monsalve Lorente Laura , García Tort Enrique
Published: March 2021

El sexting es un fenómeno en auge entre adolescentes y adultos jóvenes que consiste en enviar mensajes y/o archivos de carácter sexual a través de los smartphones y las redes sociales. Si bien no existe un claro consenso en su conceptualización, una mala gestión del sexting puede derivar en una serie de peligros como el cyberbullying o la sextorsión. El sexting es un fenómeno clave a la hora de diseñar programas de educativos sexuales en adultos jóvenes El presente estudio tiene como objetivo averiguar el grado de prevalencia del sexting en población adulta joven universitaria. Para ello se administró una serie de instrumentos a 288 estudiantes de entre 18 y 25 años de la Universitat de València, provenientes de los grados en Pedagogía, Maestro en Educación Infantil y Maestro en Educación Primaria. Los resultados indican una sexting es una práctica poco frecuente en el día a día de los adultos jóvenes, aunque el 39,2% declara haberlo practicado en alguna ocasión. A su vez, señalan como la valoración moral y la percepción del riesgo son dos factores relacionados con la frecuencia en la práctica de sexting.  Aquellos sujetos que realizan una valoración moral negativa son menos propensos a realizar sexting y más propensos a valorar dicha práctica como riesgosa. Por otro lado, se hallaron otra serie de resultados que respaldan las aportaciones de la literatura científica, como la no diferencia entre hombres y mujeres respecto a la frecuencia o la mayor frecuencia en sujetos no heterosexuales respecto a los sujetos heterosexuales.
Organic Semiconductors as Photoanodes for Solar-driven Photoelectrochemical Fuel Production
Authors: Sekar Arvindh , Sivula Kevin
Published: March 2021

The direct conversion of solar energy into chemical fuels, such as hydrogen, via photoelectrochemical (PEC) water splitting requires the efficient oxidation of water at a photoanode. While transition metal oxides have shown a significant success as photoanodes, their intrinsic
limitations make them the bottleneck of PEC water splitting. Recently, initial research reports suggest that organic semiconductors (OSCs) could be possible alternative photoanode materials in both dye-sensitized and thin film photoelectrode configurations. Herein we review the progress to
date, with a focus on the major issues faced by OSCs: stability and low photocurrent density in aqueous photoelectrochemical conditions. An outlook to the future of OSCs in photoelectrochemistry is also given.
Inhibition Mechanism of SARS-CoV-2 Main Protease with Ketone-Based Inhibitors Unveiled by Multiscale Simulations
Authors: Ramos-Guzmán Carlos A. , Ruiz-Pernía J. Javier , Tuñón Iñaki
Published: March 2021

We present the results of combined classical and QM/MM simulations for the inhibition of SARS-CoV-2 3CL protease by a recently proposed ketone-based covalent inhibitor, PF-00835231, that is under clinical trial. In the noncovalent complex formed after binding into the active site the carbonyl group of this inhibitor is accommodated into the oxyanion hole formed by the NH main chain groups of residues 143 to 145. The P1-P3 groups of the inhibitor establish similar interaction with the enzyme to those of equivalent groups in the natural peptide substrate, while the hydroxymethyl moiety of the inhibitor partly mimics the interactions established by the P1’ group of the peptide in the active site. Regarding the formation of the covalent complex, the reaction is initiated after the proton transfer from Cys145 to His41. Formation of the covalent hemithioacetal complex takes place by means of the nucleophilic attack of the Sg atom of Cys145 on the electron deficient carbonyl carbon atom and a proton transfer from the catalytic His41 to the carbonyl oxygen atom mediated by the hydroxyl group. Our findings can be used as a guide to propose modifications of the inhibitor in order to increase its affinity by the 3CL protease.
The interplay between bi-modal molecular weight distribution in polystyrene and humidity induces self-assembly of biomimetic micropillars/honeycomb morphology in the thin polymer film
Authors: Łojkowski Maciej , Chlanda Adrian , Choińska Emilia , Swieszkowski Wojciech
Published: March 2021

Segregation of polymer chains of different molecular weights is a well-known process. A traditional experimental approach of studying phase segregation in thin films composed of polymer blends with identical chemical compositions but different molecular weights was focused on functionalisation of chemical group or modification of end-group. In this study, however, a different approach was proposed. Polystyrene with bimodal molecular weight distribution, but no additional chemical modification was used. The films were prepared by spin-coating and the segregation between polystyrene phases was investigated by force spectroscopy. The solubility of bimodal polystyrene was explored. At the right molecular weight distribution and soluted in Methyl Ethyl Ketone, the phase segregation occurred. Introduction of moist airflow induced the separation of the lower molecular weight into micropillars and the heavier fraction self-organized into a honeycomb. As a result, an easy, fast, and effective method of obtaining micropillar/honeycomb morphologies was demonstrated. The mechanism of formation of such structures was explained.
On the Acid Sites of Phosphorous Modified Zeosils
Authors: Kumar Gaurav , Ren Limin , Pang Yutong , Li Xinyu , Chen Han , Gulbinski Jason , Dauenhauer Paul , Tsapatsis Michael , Abdelrahman Omar
Published: March 2021

The acid sites of phosphorus-containing zeosils were probed through a combination of solid acid characterization, density functional theory calculations, and kinetic interrogations, establishing their weakly Brønsted acidic character. Due to the disparity in acid-site strength, P-zeosils catalyzed the probe chemistry of isopropanol dehydration slower than aluminosilicate zeolites by an order of magnitude on an active site basis. Propene selectivity during isopropanol dehydration remained 20-30% higher than that of aluminosilicates, illustrating the distinct nature of the weakly acidic phosphorus active sites that favored unimolecular dehydration routes. Regardless of the confining siliceous environment, the nature of phosphorous active sites was unchanged, indicated by identical apparent uni- and bi-molecular dehydration energy barriers. Kinetic isotope experiments with deuterated isopropanol feeds implicated an E2-type elimination to propene formation on phosphorus-containing materials. Comparison of KIEs between phosphorus-containing zeosils and aluminosilicates pointed to an unchanged isopropanol dehydration mechanism, with changes in apparent energetic barriers attributed to weaker binding on phosphorous-active sites that lead to a relatively destabilized alcohol dimer adsorbate. Both ex-situ alkylamine Hofmann elimination and in-situ pyridine titration characterization methods exhibited phosphorous acid site counts dependent on probe molecules identity and/or concentration, underpinning the limitations of extending common characterization techniques for Brønsted-acid catalysis to weakly acidic materials.
Operando SAXS Study of a Pt/C Fuel Cell Catalyst with an X-ray Laboratory Source
Authors: Schröder Johanna , Quinson Jonathan , Kirkensgaard Jacob J. K. , Arenz Matthias
Published: March 2021

Small angle X-ray scattering (SAXS) is a powerful technique to investigate the degradation of catalyst materials. Ideally such investigations are performed operando, i.e., during a catalytic reaction. An example of operando measurements is to observe the degradation of fuel cell catalysts during an accelerated stress test (AST). Fuel cell catalysts consist of Pt or Pt alloy nanoparticles (NPs) supported on a high surface area carbon. A key challenge of operando SAXS measurements is a proper background subtraction of the carbon support to extract the information of the size distribution of the Pt NPs as a function of the AST treatment. Typically, such operando studies require the use of synchrotron facilities. The background measurement can then be performed by anomalous SAXS (aSAXS) or in a grazing incidence con-figuration. In this work we present a proof-of-concept study demonstrating the use of a laboratory X-ray diffractometer for operando SAXS. Data acquisition of operando SAXS with a laboratory X-ray diffractometer is desirable due to the general challenging and limited accessibility of synchrotron facilities. They become even more crucial under the ongoing and foreseen restrictions related to the COVID-19 pandemic. Although, it is not the aim to completely replace synchrotron-based studies, it is shown that the background subtraction can be achieved by a simple experimental consideration in the setup that can ultimately facilitate operando SAXS measurements at a synchrotron facility.
Microwave-assisted Automated Glycan Assembly
Authors: Danglad Flores José , Leichnitz Sabrina , Sletten Eric T. , Joseph A. Abragam , Bienert Klaus , Seeberger Peter H.
Published: March 2021

Automated synthesis of DNA, RNA, and peptides provides quickly and reliably important tools for biomedical research. Automated glycan assembly (AGA) is significantly more challenging as highly branched carbohydrates require strict regio- and stereocontrol during synthesis. A new AGA synthesizer enables rapid temperature adjustment from -40 °C to +100 °C to control glycosylations at low temperature and accelerates capping, protecting group removal, and glycan modifications by using elevated temperatures. Thereby, the temporary protecting group portfolio is extended from two to four orthogonal groups that give rise to oligosaccharides with up to four branches. In addition, sulfated glycans and unprotected glycans can be prepared. The new design reduces the typical coupling cycles from 100 min to 60 min while expanding the range of accessible glycans. The instrument drastically shorten and generalizes the synthesis of carbohydrates for use in biomedical and material science.
Taking Advantage of Ortho- and Peri-Substitution to Design Original 9-Membered P,O,Si-Heterocycles
Authors: Delouche Thomas , Caytan Elsa , Quinton Cassandre , Roisnel Thierry , Cordier Marie , Dorcet Vincent , Hissler Muriel , Bouit Pierre-Antoine
Published: March 2021

A family of 9 cyclic phosphine-disiloxane featuring peri-substituted naphthyl(Nap)/acenaphthyl(Ace) scaffolds have been prepared and fully characterized including X-ray structure, which allows a detailed structural analysis. This straightforward synthesis takes advantage of both ortho- and peri-substitution of Nap/Ace-substituted phosphine oxides. The synthetic method allows diversifying the polyaromatic platform (Nap and Ace) as well as the Si substituents (Me and Ph). Despite a strong steric congestion, the P-atom remains reactive toward oxidation or coordination. In particular, Au(I) complex could be prepared. All the compounds display absorption/luminescence in the UV-Vis range. Surprisingly, the P-trivalent derivatives display unexpected luminescence in the green in solid-state.
Janus Luminogens with Bended Intramolecular Charge Transfer: Towards Molecular Transistor and Brain Imaging
Authors: WU Qian , Liu Junkai , Li Youmei , Lee Michelle Mei Suet , hu lianrui , Zhou Panwang , Wang Dong , Tang Ben Zhong
Published: March 2021

The ingenious construction of electron donor-acceptor (D-A) system has been proven to be the major trend for novel advanced-performance optoelectronic materials. However, the related development is undiversified and become stereotyped in recent years, and the explorationsof new architecture with both prominentoptoelectronic property and innovatively coined optoelectronic mechanism are appealing yet significantly challenging tasks. We herein exploit a series of novel Janus luminogens, namely TAOs, with unique charge separation in asimple five-membered mesoionic ring.TAOs having low molecular weight present efficient aggregation-induced red/near-infrared emission with up to 21.5% of fluorescence quantum yield. A new mechanism termed as bended intramolecular charge transfer (BICT) is proposed to understand the fluorescence behavior. It is experimentally demonstrated that TAOs exhibit great potential for the use as molecular transistor, and can be efficiently utilized in brain imaging straightforwardly through intravenous postinjection.
PORTABLE PKL POWERED LANTERN
Authors: Ohiduzzaman Md. , Sultana Rajia , Khatun Rajada , Akter Shirin , Khan K.A.
Published: March 2021

It has been designed and developed the portable PKL (Pathor Kuchi Leaf) lantern for practical utilization for smart grid where grid electricity is absent. The PKL converter has been made with an insulated box and electrodes. The electrolytes were prepared by PKL extract. It was found that the portable lanterns were appropriate for PKL electric system. It is found that PKL Powered Lantern has been working well. The novelty of this research work shows that this type of work is very new one in the world. It can be used instead of solar PV sometimes. There are some advantages of this PKL systems compare to SPV (Solar Photo Voltaic) System. This PKL system can be used equally both for the rainy and night time. Whereas SPV system is not possible to use at the rainy and night time.
IEnhancer-ECNN: Identifying enhancers and their strength using ensembles of convolutional neural networks
Authors: Nguyen QH , Nguyen-Vo TH , Le NQK , Do TTT , Rahardja S , Nguyen Binh
Published: March 2021

© 2019 The Author(s). Background: Enhancers are non-coding DNA fragments which are crucial in gene regulation (e.g. transcription and translation). Having high locational variation and free scattering in 98% of non-encoding genomes, enhancer identification is, therefore, more complicated than other genetic factors. To address this biological issue, several in silico studies have been done to identify and classify enhancer sequences among a myriad of DNA sequences using computational advances. Although recent studies have come up with improved performance, shortfalls in these learning models still remain. To overcome limitations of existing learning models, we introduce iEnhancer-ECNN, an efficient prediction framework using one-hot encoding and k-mers for data transformation and ensembles of convolutional neural networks for model construction, to identify enhancers and classify their strength. The benchmark dataset from Liu et al.'s study was used to develop and evaluate the ensemble models. A comparative analysis between iEnhancer-ECNN and existing state-of-the-art methods was done to fairly assess the model performance. Results: Our experimental results demonstrates that iEnhancer-ECNN has better performance compared to other state-of-the-art methods using the same dataset. The accuracy of the ensemble model for enhancer identification (layer 1) and enhancer classification (layer 2) are 0.769 and 0.678, respectively. Compared to other related studies, improvements in the Area Under the Receiver Operating Characteristic Curve (AUC), sensitivity, and Matthews's correlation coefficient (MCC) of our models are remarkable, especially for the model of layer 2 with about 11.0%, 46.5%, and 65.0%, respectively. Conclusions: iEnhancer-ECNN outperforms other previously proposed methods with significant improvement in most of the evaluation metrics. Strong growths in the MCC of both layers are highly meaningful in assuring the stability of our models.
The Investigation of the Relationship between the Ethical Leadership Behavior of School Administrators and Social Capital Levels of Teachers: : The Case of Adana Province
Authors: KAYA Oğuz , YAŞAR Mehmet
Published: March 2021

Bu araştırmanın temel amacı, okul yöneticilerinin etik liderlik davranışları ile öğretmenlerin sosyal sermaye düzeylerinin karşılaştırılarak incelenmesidir. Araştırma modeli olarak ilişkisel tarama yöntemi kullanılmıştır. Araştırmanın
hedef evrenini, Adana ili merkez ilçelerinde bulunan 114 resmi ortaöğretim kurumunda 2015-2016 eğitim-öğretim yılında görev yapan 6371 öğretmen oluşturmuştur. Araştırmanın örneklemi ise basit seçkisiz örneklem yöntemiyle seçilen
59 okuldan 1196 öğretmenden oluşmuştur. Araştırmanın verileri, Yılmaz (2005) tarafından geliştirilen “Etik Liderlik Ölçeği” (ELÖ) ve Ekinci (2008) tarafından geliştirilen “Sosyal Sermaye Ölçeği” (SSÖ) ile toplanmıştır. Verilerin
analizinde etik liderlik ve sosyal sermaye değişkenleri arasındaki ilişki için korelasyon ve regresyon analizleri uygulanmıştır. Regresyon analizi sonucunda (B=0.62; p<0.05), açıklanan varyans olarak sosyal sermaye değişkenindeki
değişkenliğin %47 sini etik liderlik değişkeni ile açıklanabileceğini söyleyebiliriz (∆R2=0.47; p<0.05). Yöneticilerin etik liderlik davranış düzeyleri ile öğretmenlerin sosyal sermaye düzeyleri arasında “pozitif” yönde ve “orta”
düzeyde anlamlı bir ilişki olduğu; yöneticilerin etik liderlik davranışlarının öğretmenlerin sosyal sermaye düzeylerini anlamlı bir şekilde yordadığı, sosyal sermaye düzeyindeki değişkenliğin %47’sini etik liderliğin; aynı şekilde
etik liderlik düzeyindeki değişkenliğin de %47’sini sosyal sermaye değişkeninin açıkladığı söylenebilir. Araştırma bulguları ışığında okul yöneticilerine önerilerde bulunulmuştur.