bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pengakuan Pendapatan Berdasarkan Psak 72 Terhadap Kualitas Laba Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia (BEI)
Authors: Maulana Jaka , Susanto Dinka Mutiafany
Published: July 2024

Kasus kecurangan pembuatan laporan keuangan tidak bisa di hindarkan. Banyak skandal akuntansi yang menunjukkan praktik penipuan untuk memanipulasi data keuangan terlebihnya dalam akun pendapatan di mana yang seharusnya belum bisa diakui tetapi sudah diakui, padahal harus sesuai dengan standar yang berlaku seperti PSAK. Jika pengakuan pendapatan yang tidak tepat, laporan laba rugi tidak akan mencerminkan kondisi keuangan yang sebenarnya, sehingga mengurangi kepercayaan dan validitas laporan keuangan tersebut. Dengan adanya PSAK 72 yang baru diterapkan, penelitian ini bertujuan ingin melihat apakah pengakuan pendapatan atas standar ini dapat mempengaruhi kualitas laba perusahaan. Dalam penelitian ini, hasil penelitian diharapkan dapat menjadi kriteria tambahan untuk penelitian serupa tentang pengaruh pengakuan pendapatan berdasarkan PSAK 72 terhadap kualitas laba di perusahaan-perusahaan yang tercatat di Bursa Efek Indonesia (BEI). Data yang diolah berasal dari 39 sampel Laporan Keuangan di BEI dan diolah dengan menggunakan IBM SPSS Statistic 25 dengan Uji Normalitas, Uji Product Moment, Uji Regresi Linear Sederhana, Analisis Regresi Linear Berganda, Analisis Koefisien Determinasi dan Uji t. Temuan utama menunjukkan bahwa hasil uji t yang diolah IBM SPSS Statistics 25 mendedikasikan adanya pengaruh negatif antara pengakuan pendapatan berdasarkan PSAK 72 terhadap kualitas laba perusahaan
Fake News Detection and Classification with Recurrent Neural Network Based Deep Learning Approaches
Authors: Çetiner Halit
Published: July 2024

Events happening in the world are transmitted to the end user through the news channel. The information transmitted from the news is generally considered to be accurate. However, there may be errors or lies in the information that circulates on the news channels. At the same time, this news has an impact on serious environments, such as the economy. In social networks where data sharing is increasing, news data is piling up uncontrollably. In these data piles, there is real information as well as different information that is not real commercial, political, or sales-orientated. False information and data expand faster as a result of sharing false information by users. This news directly affects users, causing erroneous transactions, misinformation, or financial loss. For the stated reasons, automatic fake news classification systems are proposed in this article by combining natural language processing with Recurrent Neural Network (RNN) based deep learning methods. The proposed systems were tested on a dataset containing 23,481 fake news and 21,417 real news using general performance metrics. As a result of the test processes, the proposed BiLSTM method provided 99,72% accuracy, while the proposed GRU method accessed 97,50% accuracy.
Bir Çimento Fabrikasında Aydınlatma, Termal Konfor ve Titreşim Maruziyetinin Değerlendirilmesi
Authors: Delice Hatice Rumeysa , Koçbulut Fikret
Published: July 2024

Fiziksel çevre, insanın yaşadığı ortamın sıcaklık, soğukluk, titreşim, gürültü, alçaklık, yükseklik ve nem gibi etmenlerin oluşturduğu fiziksel ve kimyasal özellikleri ile iş güvenliği açısından öne çıkar. Hem işçi sağlığı ve güvenliği (İSG) açısından hem de işletmelerde istenen verimliliğin sağlanabilmesi için çalışma ortamı koşullarının önemi çok fazladır. Çalışanlar, kendilerini rahat hissettikleri koşullarda verimli çalışabilir. Kötü çalışma koşulları olan işyerlerindeki yetersiz havalandırma, aydınlatma, ısıtma gibi fiziksel koşulların uygunsuzluğu, iş güvenliğinin olmaması çalışan bireylerin sağlığını olumsuz yönde etkiler ve verimin düşmesine sebep olur. Bu nedenle, çevre koşullarının fiziksel açıdan çalışanların hayat fonksiyonlarını tehdit etmeyen, sıkıntı ve rahatsızlığa yol açmayan, ısı, havalandırma, gürültü, nem, titreşim aydınlatma vb. konularla ilgili sorunlardan arındırılmış olması gerekir. Bu çalışmada bir çimento fabrikasında İş Sağlığı ve Güvenliği açısından önemli bir konu olan fiziksel risk etmenlerinden; aydınlatma, termal konfor ve titreşim parametrelerinin ölçümleri ve değerlendirmesi yapılmıştır. Çalışma sonucunda fiziksel risk etmenleri için alınabilecek çözüm önerilerine değinilmiştir. Çalışma birinci yazarın Cumhuriyet Üniversitesi Fen Bilimleri Enstitüsü, İş Sağlığı ve Güvenliği anabilim dalında hazırlanan Yüksek Lisans tezinden türetilmiştir.
Effect of Microencapsulated Goat Clarified Butter on Free Fatty Acids and Physicochemical Properties in Cow Butter Production
Authors: Albayrak Karaoğlu Aslı
Published: July 2024

In the study, goat clarified butter was encapsulated using a concentric nozzle and the microencapsulation process. The cow creams were mixed with encapsulated goat clarified butter in various quantities and left for a week. The study looked at the physical and chemical qualities, as well as the levels of free fatty acids and α-tocopherol, of cow butters that had different amounts of goat ghee microcapsules added to them. % Lactic acid, acid value, Polenske number, and α-tocopherol of cow butter all went up significantly when encapsulated goat butter was added (p
Rare earth mineralization in ores of the Gurvunur apatite-magnetite deposit (Ozerny ore cluster, Western Transbaikalia)
Authors: Izvekova Aleksandra , Damdinov Bulat , Rampilov Mikhail
Published: July 2024

The Gurvunur apatite-magnetite deposit is located within the Ozerny ore cluster in Wes-tern Transbaikalia. A peculiarity of this object is the presence of rare-earth mineralization in the ores. The main REE concentrator minerals include monazite, allanite, apatite, and epidote. One of the main concentrators of REE is apatite, where the content of REE sum reaches 2.6 wt. %. The REE are mainly represented by light lanthanides, with La up to 1.8 wt. % and Ce up to 2.08 wt. % predominating. Monazite- (Ce) is formed in the process of apatite refining, leading to the monazite fine-grained dissemination and veinlets occurring. Epidote is found in nests and vein-like formations of skarn aggregates. The mineral mainly contains light lanthanides (La up to 5.11 wt. %, Ce up to 2.47 wt. %) and forms gradual transitions to allanite that, in its turn, is also found in the form of isolated segregations or as a part of aggregates of epidote-allanite composition. Light lanthanides with Ce up to 14.35 wt. % and La up to 9.16 wt. % pre-dominate in the allanite composition. The study of the mineral composition and distribution of REE in ores and minerals allows us to conclude that rare-earth mineralization in the ores of the Gurvunur apatite-magnetite deposit was formed as a result of skarning of the carbonate-bearing volcanogenic-sedimentary rocks, and the source of rare-earth mineralization was granodiorites of the Vitimkan intrusive suite.
The Changes We Need: Contribution of Personalized Learning in the Development of New Theoretical Model for Education
Authors: Ding Feng , Santos Joseline M. , Borja II Ruben E.
Published: July 2024

Purpose: The main purpose of this study is to explore how may the contribution of the personalized learning assessed as basis for the development of the new theoretical model in universities in Guangdong, China. Method: The study utilized a mixed-method approach to research using Explanatory Sequential Design (Two-Phase). In this type of research, the researcher collects an initial quantitative data collection, and analyzes the data to build up on a second, qualitative phase. This procedure helps explain the quantitative results through a qualitative dimension. Result and Conclusion: The study found that the level of presentation of personalized learning practices among Chinese university students is not ideal. Classroom instructors are not sufficiently prepared to implement personalized learning among students, and university administrators also lack adequate preparation for motivating and leading the development and implementation of personalized learning. However, Chinese university students, teachers, and administrators all hold a positive attitude towards personalized learning. They recognize the significance of personalized learning for student development and the reforms in education for the new era. They would actively promote relevant practices. The study synthesized the perceptions of students, teachers, and administrators and developed a new theoretical model to enhance the universities’ practices of personalized learning. Research implications: The study highlights the importance of bridging the gap between positive attitudes towards personalized learning and the actual implementation of these practices, emphasizing the need for strategic interventions and support mechanisms to ensure successful integration into university settings. Originality/ Value: The study focused on the Chinese university context, its identification of implementation gaps, its recognition of positive attitudes towards personalized learning despite challenges, and its development of a new theoretical model to enhance personalized learning practices. These aspects contribute to the advancement of knowledge and understanding in the field of personalized learning within the context of Chinese higher education.
Desempeño reproductivo de hembras bovinas utilizadas unicamente como receptoras en un programa de transferencia de embriones en el trópico cálido-subhúmedo
Authors: Lammoglia-Villagómez Miguel Ángel , Martínez de la Cruz Caín , Sánchez-Montes Daniel Sokani , Avalos-Rosario Ivan Isaías , Chagoya-Fuentes Jorge Luis
Published: July 2024

La producción de embriones bovinos se ha incrementado exponencialmente en los ultimos años. El número de gestaciones depende de múltiples factores siendo el manejo reproductivo de las receptoras uno de los más importantes. El objetivo fue evaluar el desempeño reproductivo de vacas F1 cebú x suizo europeo utilizadas unicamente para receptoras en un programa de transferencia de embriones. La investigación se realizó en una unidad de producción pecuaria (UPP) en el municipio de Tamiahua, Veracruz. El estudio fue retrospectivo (Abril 2009-Noviembre 2023) y se utilizo la información de 116 receptoras. Los embriones y ovocitos fueron colectados de las donadoras Brahman de la UPP y los embriones fueron producidos in vitro por la empresa ABS en Torreón, Coahuila. El análisis estadístico se realizo utilizando el programa STATISTICA 7. El primer parto fue a los 42.2±9.1 meses de edad. Posteriormente las receptoras tuvieron parámetros reproductivos similares (P>0.05) en los diferentes partos con una media de 1.58±0.80 servicios por concepción (SPC), 193.3±122.5 días abiertos (DA) y 16.0±5.4 meses de intervalo entre partos (IEP) con un total de 4.0±1.6 partos y una estancia en la UPP de 7.9.±1.9 años. El porcentaje de desecho incrementó significativamente (P<0.05) en receptoras de 4 y 5 partos (46.2%) comparado con las de tres y menos partos (6.2%). En conclusión, el desempeño reproductivo de hembras bovinas utilizadas unicamente como receptoras en un programa de transferencia de embriones en el trópico cálido-subhúmedo fue satisfactorio y tuvieron un promedio de 4.0±1.6 partos durante 7.9.±1.9 años. El porcentaje de desecho de receptoras de más de 4 y 5 partos incrementó significativamente comparado con las de tres o menos partos.
USO INDISCRIMINADO DE ANTIBIÓTICOS E POSSÍVEIS RISCOS DE RESISTÊNCIA
Authors: Murad de Almeida João Victor , Daudt Pereira Letícia , Machado Ferreira Millena , Cordeiro Vieira Vitor , Silva Araújo Carneiro Peixoto Wagner
Published: July 2024

A resistência bacteriana aos antibióticos é um dos maiores desafios enfrentados pela medicina moderna. O surgimento e a disseminação de bactérias resistentes comprometem a eficácia dos tratamentos disponíveis, aumentando a morbidade e a mortalidade associadas a infecções bacterianas. O presente estudo tem como objetivo investigar as práticas de prescrição de antibióticos e sua relação com o desenvolvimento de resistência bacteriana. A pesquisa busca mapear os padrões de uso de antimicrobianos, identificar os fatores que contribuem para o uso inadequado e avaliar o impacto dessa prática na saúde pública. Diante da análise dos estudos dispostos nesta revisão, observou-se que a resistência bacteriana representa um desafio significativo para a saúde pública global. Reconhece-se que a principal causa identificada é o uso irracional de antimicrobianos, exacerbado pela automedicação e prescrição inadequada. Os mecanismos de resistência são diversos e complexos, destacando a necessidade urgente de novas estratégias terapêuticas e de políticas eficazes de controle de infecções.
Smart Recognition and Authentication based on Haar Cascade Classifier and Visual Cryptography
Authors: Bose Saikat , Arjariya Tripti , Goswami Anirban
Published: July 2024

The algorithm with an E-verification method is proposed that combines automated facial recognition technology with digital media and later it combines aspects of secret data exchange and visual cryptography. A face detection technique based on Internet of Things (IoT) selects features using the Principal Component Analysis (PCA) algorithm and the Haar cascade classifier. The selected face serving as a cover follows two level Discrete Haar Wavelet Transform. The shares generated from digital signature and fingerprint are diffused into the converted coefficients. Furthermore, the imperceptibility of the additional noise is increased by a bit-level noise reduction technique. Authenticity is confirmed by regenerating a message digest at the receiving end, and the extraction process operates in complete blindness. The approach is suitable for smart card design and may be used as an automatic recognition system in a real-world setting. Performance comparisons show a notable improvement over other approaches that are comparable. Additionally, the technique is effective against some related attacks.
An Optimized Framework Based on Data Exploration and Dynamic Ensemble-Based Models for Breast Cancer Prediction
Authors: Alsabry Ayman , Qasem Hamzah Ali Abdulrahman , Algabri Malek , Ahsan Amin Mohamed , Mosleh Mogeeb A. A. , Hanash F. E.
Published: July 2024

Breast cancer (BC) is a major global health concern. Detecting BC at an early stage gives more treatment options and can help avoid more aggressive treatments. The use of machine learning (ML) in BC prediction offers significant potential for improving the accuracy and speed of diagnosis, personalizing treatment, and identifying high-risk patients.  However, there are significant challenges associated with the use of ML, including the need for high-quality data and more flexible models with optimal parameters to achieve high efficiency. In this paper, we propose an optimized framework based on multi-stage data exploration. This framework is designed to provide a comprehensive approach to data exploration, ensuring that the data is well-prepared for ML. In addition, the framework includes dynamic ensemble-based classifiers, which combine multiple independent classifiers to improve accuracy and mitigate the risk of overfitting in conjunction with the cross-validation techniques. These classifiers are optimized using Bayesian hyperparameter tuning, which involves selecting the optimal values for the various hyperparameters of the model. This approach can significantly improve the prediction accuracy of the resulting model. The study evaluates the framework using the publicly available Wisconsin Diagnostic Breast Cancer (WDBC) dataset and compares our results with other state-of-the-art models. The experimental results show that the best result is 100% for accuracy and recall with hyperparameters of (Ensemble Method = AdaBoost, Number of learners = 322, learning rate = 0.9350, and the Maximum number of splits = 1). The highest performance has been achieved with the proposed framework compared with the other models in terms of accuracy (mean = 99.35%, best = 100%, worst = 98.7%, and Standard Deviation = 0.325). The framework can potentially improve the accuracy and efficiency of BC prediction, ultimately leading to better outcomes for patients.
Advancements in Understanding and Managing Deep Vein Thrombosis: A Contemporary Perspective
Authors: Khan Mohd Maruf , Begum Mehmooda , Anees Arif , Mishra Akanksha
Published: July 2024

Deep vein thrombosis (DVT) refers to the formation of blood clots within the deep veins, typically affecting those in the pelvis or lower extremities, including the calf, femoral, and popliteal veins. DVT poses a significant global healthcare challenge due to its potential to cause life-threatening complications like pulmonary embolism. Recent years have seen substantial progress in comprehending the pathophysiology of DVT and in enhancing strategies for its prevention and management. This review article presents a contemporary viewpoint on the progress made in understanding and addressing DVT, focusing on advancements in epidemiology, risk factors, diagnosis, treatment, and preventive measures.
Menstrual cycle disorders: a correlation with genetic alterations
Authors: Mishra Shrishti , Verma Arti , Tiwari Archita , Mishra Bharat
Published: July 2024

The menstrual cycle is considered the fifth vital sign among women. The pituitary, thyroid, pancreas, adrenal, and ovaries are endocrine glands that play a crucial role in governing the menstrual cycle. Endocrine ailments trigger periods of menstruation disturbances throughout a woman's reproductive life. The duration and volume of menstrual bleeding can serve as indicators of endocrine problems. Oligomenorrhea, which refers to monthly periods longer than 35 days, is the most prevalent menstrual disruption observed in endocrine illnesses such as thyrotoxicosis, hypothyroidism, polycystic ovarian syndrome, Cushing's syndrome, and diabetes, based on the existing evidence. The intricate endocrine pathways are crucial in regulating a woman's menstrual cycle.. Menstrual Irregularities are caused due to eating disorders, extreme weight loss or too much exercising, Polycystic ovary syndrome (PCOS), Premature ovarian failure, Pelvic inflammatory disease (PID) and Pregnancy or breast-feeding. Mensesare affected by various factors like junk food, obesity, skipping breakfast lack of physical activity etc. PCOS, Diabetes, Hyperprolactinemia, Hypothyroidism, Thyrotoxicosis, and Cushing’s syndrome are some menstrual disorders which occur due to genetic alterations. All these disorders can be primarily treated by Nutritional Considerations and herbal treatments. In order to achieve a regular menstrual cycle and overcome these diseases, nutritional supplements and lifestyle modifications must be prioritized.
An Empirical Study on Vicarious Liability in Medical Negligence
Authors: Mythili Bhoobalan  , MRS. U. Ragavee
Published: July 2024

Vicarious liability is a legal principle that holds an employer or principal accountable for the wrongful actions of their employees or agents while acting within the scope of their duties. In the realm of healthcare, the doctrine of vicarious liability plays a significant role in cases of medical negligence, where patients seek compensation for harm caused by healthcare professionals. The term “medical negligence” is an omnibus one, which has come in vogue to refer to wrongful actions or omissions of professionals in the field of medicine, in pursuit of their profession, while dealing with patients. It is not a term defined or referred to anywhere in any of the enacted Indian laws. A basic knowledge of how judicial forums deal with the cases relating to medical negligence is of absolute necessity for doctors. The need for such knowledge is more now than before in light of higher premium being placed by the Indian forums on the value of human life and suffering, and perhaps rightly so. Indian society has been witnessing the growing awareness regarding the rights of patients. This abstract presents a comprehensive analysis of vicarious liability concerning medical negligence. It delves into the underlying principles, case precedents, and factors influencing the application of this doctrine in the healthcare context. The objective is to provide a clear understanding of the legal implications for healthcare institutions and professionals in such scenarios. Negligence in the medical field is now more careless and we can observe the significant failure. Medical negligence occurs due to not ensuring a standard of care that must be provided. Liability of the hospital as an employer for negligent act. The method used here is empirical research. The final observation from this research is that the medical negligence occurs due to negligence of hospitals and authorities
PROPUESTA DE VALOR, FACTOR CLAVE PARA EL ÉXITO DE LOS EMPRENDIMIENTOS
Authors: Mora Aristega Julio Ernesto , García León Erika Paola , Ley Leiva Nelly Victoria
Published: July 2024

Una propuesta es uno de los elementos claves del posicionamiento de una empresa, es una herramienta esencial para enfocarse en lo que más importa y servirá de base para las campañas de marketing y argumentos de venta, además es la carta de presentación ante los clientes. Una buena propuesta debe destacar lo que hace diferente a una empresa o servicios de los competidores, pero siempre debe centrarse en cómo los clientes definen el valor.  La propuesta de valor es definida también como un punto de inflexión entre la estrategia empresarial y la estrategia de marca, sin embargo, muchas empresas suelen mezclar ambas dimensiones y terminan adoptando una propuesta demasiado vaga o general, o incluso olvidándose de tener una; en este trabajo se muestran las características que deben tener, las consideraciones a tener en cuenta previo a la generación de una propuesta de valor para los clientes, además de los elementos necesarios durante el desarrollo de la misma; considerando el mercado, la experiencia, el producto o servicio y las alternativas y diferencias que existen entre nuestro producto y la competencia.
AUDITORÍA
Authors: Borbones S. Víctor , Martínez González Clímaco
Published: July 2024

Esta investigación va dirigida a los colaboradores de la Oficina de Fiscalización de Prestaciones Económicas, para facilitar la revisión de los expedientes de indemnizaciones por vejez.  Es un modelo de trabajo para los fiscalizadores, permitiendo una mejora continua en el desarrollo de sus labores cotidianas y de igual manera indujo al personal que rota o llega nuevo, en el desarrollo de sus labores. Se utilizó un cuestionario, como instrumento de aplicación metodológica para obtener la información requerida de la unidad de Fiscalización para conocer el procedimiento existente. Entre los resultados esperados sugirió un fuerte apoyo para la implementación de un modelo a seguir de fiscalización para unificar criterios, facilitar trámite de verificación y refrendo.
The approximators about, at least and nearly as interpersonal devices in nineteenth-century women’s instructive texts
Authors: Quintana Toledo Elena
Published: July 2024

This paper aims at describing how about, at least and nearly are used in the nineteenth-century subcorpus of the Corpus of Women’s Instructive Texts in English, which gathers instructional texts exclusively written by women. While still retaining their approximative sense, about, at least and nearly have a large potential to build and maintain writer-reader interpersonal relationships. The most frequent collocational patterns have been firstly identified by using corpus tools to later analyse the major pragmatic functions of specific examples following Zhang’s (2015) framework for elastic language. Findings reveal that collocations with numerical expressions are common to about, at least and nearly while other patterns only emerge with about and nearly. It also seems that pattern and function are tightly interwoven. In general, the approximators surveyed here fulfill a variety of interpersonal functions, most notably, just-right elastic, rapport elastic, mitigating elastic, self-protection elastic, and intensifying elastic.
Facets, a többdimenziós mérés eszköze
Authors: Dávid Gergely András
Published: July 2024

Az itt bemutatott Facets szoftver (Linacre, 2024) lehetőséget teremt az idegennyelv-tudás komplex, több dimenziós mérésére és – tágabb értelemben – a mérés-értékeléshez közvetett módon kapcsolódó, vagy akár nem kapcsolódó projektek eszközeinek, hatástényezőinek vizsgálatára, az érvényesítés (validálás) céljával. A Facets megvalósítja a kommunikatív nyelvtudás összetett, többdimenziós mérésének feladatát, ahogy azt Morrow, Canale és Swain és mások elképzelték: a bevett tényezők, dimenziók mint a feladat nehézsége és az értékelők szigora mellett további dimenziók azonosítására és értékelésére is van lehetőség. Viszonylag kis létszámú adatcsomagok feldolgozására is alkalmas, adott eljárás követése esetén, ami szélesíti a lehetséges felhasználók körét az oktatási rendszeren belül és kívül.
Szótárdidaktika a közoktatásban. Idegen nyelvet oktató tanárok szótárhasználati szokásai és a szótárhasználat oktatásának gyakorlata – egy kvantitatív kutatás eredményei
Authors: P. Márkus Katalin
Published: July 2024

Jelen tanulmány egy hosszabb tanulmánysorozat lezárásának tekinthető, amelyben igyekeztem speciális igényekre szabott szótárak, valamint segédanyagok (például tanulószótárak, szótárhasználati munkafüzetek) oktatásba történő beépítésének lehetőségeit bemutatni. Zárásként egy felmérés eredményét közölve, gyakorló tanárok szótárhasználati és szótárdidaktikához fűződő kapcsolatát igyekszem ismertetni. Jelen felmérés a szótárhasználat intézményi keretek között történő oktatásába ad bepillantást, rávilágítva azokra a területekre, ahol a nyelvtanulás során előkerülnek a szótárak. Az alábbi kutatás eredményei árnyaltabban határozzák meg a jövőbeli fejlesztendő területeket, egyben irányt szabnak az új tanulási módszereknek.
LINC00847 drives pancreatic cancer progression by targeting the miR-455-3p/HDAC4 axis
Authors: Hao Shunxin , Yao Zhi , Liu Yifeng
Published: July 2024

Introduction

Pancreatic cancer (PC) is a common malignant tumor of the digestive system, posing a serious threat to the life of patients. This study aims to investigate the role of LINC00847 and the LINC00847/miR-455-3p/HDAC4 mechanism in PC progression.

Material and methods

The RNA levels of LINC00847, miR-455-3p and HDAC4 were determined by RT-qPCR. HDAC4 protein level was assessed by western blotting. Colony formation and CCK-8 assays were employed to test the proliferation of PC cells. Transwell and scratch assays were conducted to evaluate the cell invasive and migratory abilities, respectively. The effect of LINC00847 silencing on PC cells in vivo was verified using a mouse xenograft model. The correlation among LINC00847, miR-455-3p and HDAC4 was ascertained by dual-luciferase reporter (DLR) assay and Pearson’s correlation analysis.

Results

The result showed that LINC00847 mainly localized in the cytoplasm was upregulated in PC cells and tissues. Downregulating LINC00847 hindered migration, proliferation, and invasion of PC cells in vitro. Moreover, it also suppressed tumor growth in an in vivo xenograft model. LINC00847 was found to directly target miR-455-3p. miR-455-3p overexpression inhibited cell proliferation and invasion. In addition, HDAC4 was confirmed to be a target gene of miR-455-3p, and HDAC4 overexpression overturned the impact of LINC00847 knockdown on PC cell progression.

Conclusions

Our findings reveal that LINC00847 potentially plays a key role in the carcinogenesis of PC progression. This effect may be mediated via regulating the miR-455-3p/HDAC4 axis. This study provides insights into the intricate molecular mechanisms underlying PC and opens avenues for potential therapeutic interventions.
Women suffering from systemic lupus erythematosus are characterized by low blood levels of α-dicarbonyl compounds
Authors: Nowak Agnieszka , Przywara-Chowaniec Brygida , Damasiewicz-Bodzek Aleksandra , Janoszka Beata , Szumska Magdalena , Waligóra Sławomir , Tyrpień-Golder Krystyna
Published: July 2024

Introduction

Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease, often characterised by severe course and unclear etiopathogenesis. The reaction of protein glycoxidation, also known as glycation, may be linked to etiopathogenesis of SLE. Advanced glycation end-products (AGEs) exhibit cytotoxic properties, affect cellular signalling, impair functions of extracellular proteins, and may act as neoepitopes. Glucosone (GS), glyoxal (GO), and methylglyoxal (MGO) are examples of α-dicarbonyl compounds (α-DCs) partaking in glycoxidation. The study aimed to evaluate concentrations of these three compounds in blood serum of SLE patients, and to compare the results with healthy individuals.

Material and methods

31 women suffering from SLE and 26 healthy individuals were included in the study. High-performance liquid chromatography with fluorescence detection was applied to evaluate concentrations of α-DCs in their serum samples. Correlations between the results and parameters such as disease duration time, age, glomerular filtration rate (GFR), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and creatinine were analysed.

Results

The SLE patients exhibited lower concentrations of glucosone, glyoxal, and methylglyoxal than the control group. Analysis of correlations showed a difference between the examined groups.

Conclusions

In women suffering from SLE the course of α-DCs metabolism is altered. SLE patients are characterised by low serum levels of α-DCs. We hypothesise that either hindered proteasomal degradation or fast consumption of α-DCs in oxidative conditions may cause the observed low concentration of these compounds.
Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction
Authors: Banjac Katarina , Obradovic MIlan , Zafirovic Sonja , Isenovic Esma R.
Published: July 2024

Introduction

Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption.

Methods

Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α1 subunit of sodium/potassium-adenosine triphosphates (Na+/K+-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured.

Results

The results indicate that IGF-1 decreased Beclin-1’s association with Na+/K+-ATPase (p < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (p < 0.05), and decreased AMPK phosphorylation (p < 0.01) in rats’ hearts.

Conclusions

The new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality.
Acute renal failure caused by Sjögren’s syndrome and rheumatoid arthritis overlap syndrome
Authors: Ran Lei , Zhang Ya-pu , Guo Li , Wang Zhi-min , Zhang Jian-min
Published: July 2024

Introduction

Sjögren’s syndrome (SS) and rheumatoid arthritis (RA) are two chronic autoimmune diseases. To date, there have been few reports on the overlap between SS and RA in China, especially regarding correlated acute renal failure cases.

Material and methods

To provide a reference for our clinical peers, this article presents the case report of an elderly female patient who was diagnosed with acute renal failure caused by SS and RA overlap syndrome.

Results

We also provide a relevant analysis of SS and RA overlap syndrome treatment.

Conclusions

We also provide a relevant analysis of SS and RA overlap syndrome treatment.
Bifacial Photovoltaic yield Simulation as a Function of the Albedo
Authors: Grommes Eva-Maria
Published: July 2024

Die Bifacial-Photovoltaik-(PV-)Technologie markiert einen bedeutenden Fortschritt im Bereich der Solarenergie. In der vorgelegten Dissertation wird mit BifacialSimu ein innovatives, ganzheitliches Open-Source-Simulationstool für die Energiesystemsimulation von bifazialen Photovoltaik-Systemen präsentiert. Dieses Tool unterscheidet sich signifikant von existierenden Methoden durch die Integration eines umfassenden Analyseansatzes, der die Albedo berücksichtigt und spezialisierte Lösungsstrategien für diverse Anwendungsgebiete, einschließlich agrarwirtschaftlicher PV-Installationen, bietet. Dadurch leistet die Dissertation einen bedeutenden Fortschritt in der photovoltaischen Forschung und Praxis, indem sie den Zugang zu fortgeschrittenen Simulationswerkzeugen demokratisiert und die Effizienzsteigerung sowie Optimierung bifazialer PV-Systeme unterstützt. Index 1 Introduction 1 1.1 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2 Research objectives and approach . . . . . . . . . . . . . . . . . . . . . . . . 3 1.3 Dissertation outline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2 State of the...
Industrial Anomaly Detection with Normalizing Flows
Authors: Rudolph Marco
Published: July 2024

This thesis addresses deep learning-based methods for automatic anomaly detection in an industrial context. It involves image- or sensor-based detection of defects in the production process that can affect the quality of products. Automating this task provides a reliable and cost-effective alternative to humans, who perform this task manually by sighting. Since this setup has special requirements such as detecting previously unknown defects that traditional approaches cannot fulfill, this paper presents anomaly detection methods that learn without any examples of anomalies and include only normal data in the training process. Most of our proposed methods address the problem from a statistical perspective. Based on a deep-learning-based density estimation of the normal data, it is assumed that anomalies are considered unlikely according to the modeled distribution. The density estimation is performed by socalled Normalizing Flows, which, in contrast to conventional neural networks, can model a formally valid probability distribution due to their bijective mapping. Moreover, due to their flexibility, Normalizing Flows allow modeling of more complex distributions in contrast to tradit...
Leveraging an African-Centered Language Model (LLM) for Dismantling White Supremacy: The Case of “SMOKY”
Authors: Bussaja Janga
Published: July 2024

The system outlined in this proposal exists in a conceptual phase, awaiting the necessary resources for implementation. The theoretical framework presented herein lays the foundation for the development and deployment of 'Smoky,' an innovative artificial intelligence system designed to confront systemic racism. Grounded in African-centered scholarship and equipped with sophisticated monitoring capabilities, 'Smoky' stands as a pioneering endeavor in the realm of leveraging technology for social equity. This scholarly exploration delves into the conceptualization, development, and potential applications of 'Smoky' as a formidable asset in the ongoing struggle against racial injustice. As with any transformative idea, securing funding and support is paramount to transitioning from theory to tangible action. This paper serves as a call to philanthropists and potential collaborators to join in the realization of this vision, contributing to the advancement of technology-driven solutions for social justice.
AGING MANAGEMENT WITH THE USE OF EXOSOMES, PRP/PRF WITH ALBUMIN GEL (PLASMA GEL) AND ASSOCIATED TECHNIQUES IN OROFACIAL HARMONIZATION TREATMENT
Authors: Maso Adelaide
Published: July 2024

Aging, it is a physiological process that involves a progressive decline in the function of the organs, with loss of homeostasis and increased likelihood of disease disease and death. This account focuses on the classic perspectives on the biogenesis of exosomes, and age-related associated changes. Due to its ability to transmit biological information between cells, this work also discusses the interaction of mesenchymal cell exosomes, as a potent adjuvant in the treatment of association of orofacial harmonization techniques. The demand for aesthetic and rejuvenating treatments is increasing in society, thus, each day, the demand for orofacial harmonization increases exponentially in order to slow aging. Orofacial harmonization is a set of procedures performed by the dentist, which aims at the aesthetic and functional balance of the face. Exosomes are membranous extracellular vesicles ranging from 30 to 200 nm in diameter. Exosomes has been found to be secreted by most cell types, including immune cells (B cells, T cells, mastocytes, dendritic cells), neuronal cells, epithelial cells, endothelial cells, embryonic cells, cancer cells and cells mesenchymal trunk (mscs). The search for youth and perfect skin is a natural desire for the human being. And in this way, collagen biostimulation stands out as a safe and effective option to rejuvenate the skin, fighting the signs of aging and promoting a firmer, toned and radiant appearance. Research in exosomes therapies continues to prosper. Subsequent data on indications, dose response, safety, effectiveness and ability to combine therapy with exosomes as a “skin primer” for biostimulation techniques, such as calcium hydroxylapatite (CAHA), platelet rich plaketers (PRP) and fibrin matrix Platelet plasma, (PRFM) is growing rapidly.
Being AND Becoming a Wise Leader
Authors: Kessler Eric H.
Published: July 2024

Despite the burgeoning literature around leadership there is a lack of theoretical integration as well as practical inconsistencies in terms of how its insights relate to actually a) being a leader and b) becoming a leader. Utilizing a wisdom-based template offers a path to synergistically combine academic models so to gain a holistic understanding of its higher-order mega-competencies – foundational, multidimensional and context specific leadership tools – and its subsequent meta-heuristics – capacities for matching appropriate leadership identities, roles, and behaviors to address dominant leadership challenges. As such, and specifically by focusing on ideas seeded from the foundational work of Plato’s Republic, this type of perspective represents a potentially useful approach for reconciling seemingly divergent approaches and advance how we might think about the leadership role and its intersection with transcendent ideas of reason, emotion, value, spirit, connection, and success.
The impact of climate change on the development of agriculture in agro-ecological zones of the Republic of the Niger
Authors: Dedova Elvira ,   Hydraulic Engineering and Land Reclamation Center named after A.N. Kostyakov, Yasine Abdou Barke , Shabanov Rustam , Dedova Alena ,   State University of Land Use Planning,   Hydraulic Engineering and Land Reclamation Center named after A.N. Kostyakov,   State University of Land Use Planning
Published: July 2024

Climate change poses a significant threat to the ecosystems and biodiversity of the Niger Republic, especially given the critical role of vegetation cover in maintaining the resilience of local ecosystems. This study analyzed the impact of climate change on vegetation in Niger using geoinformation systems and remote sensing technologies. The main research method was the analysis of satellite data from MODIS, Landsat and Sentinel, as well as the use of climate data from the NASA POWER Data Access Viewer portal. The results showed a significant increase in average annual temperatures and a decrease in precipitation in various climatic zones of the country, which negatively affects the state of vegetation and agriculture. NDVI analysis revealed degradation of vegetation cover in the northern and eastern regions of the country, indicating the need to develop adaptation strategies and sustainable management of natural resources. Keywords: REPUBLIC OF THE NIGER, GEOINFORMATION ANALYSIS, REMOTE SENSING OF THE EARTH, GEOINFORMATION SYSTEMS, VEGETATION COVER, AGRICULTURE, ATMOSPHERIC PRECIPITATION
Sorghum is an alternative grain crop in meat and poultry farming
Authors: Sazonova Irina ,   RosNIISK Rossorgo, Erohina Anna , Bychkova Vera , Svetlov Vladislav ,   Vavilov University,   RosNIISK Rossorgo
Published: July 2024

Realization of the genetic potential of farm animals and poultry is possible only with the use of complete diets. Along with the traditional plant components of feed, alternative agricultural crops that are capable of high yields in adverse environmental conditions, such as drought and salinity, are of great help in forage production and at the same time have a high nutritional value. The article presents the results of studies on the use of grain sorghum as a component of combined feed for broiler chickens in the conditions of the Saratov region. In experimental feeds, sorghum was replaced by cereals ‒ barley and wheat, which are traditional components for feed mixtures. After a preliminary study of the biochemical composition of the feed components, prototype feed samples were compiled, in which the nutritional value was determined by the main indicators - protein, fat, fiber, ash, BEV, the exchange energy was calculated and the fractional composition of the protein was studied - albumins, globulins, glutelins, prolamins. After analyzing the combination of all indicators of the feed value of the studied compound feeds, sample N 3 was selected, in which grain sorghum was used instead of barley, with optimal characteristics, and recommended for further use. Keywords: SORGHUM, COMPOUND FEED, BROILER CHICKENS, METABOLIC ENERGY, FEED VALUE, PROTEIN, PROTEIN FRACTIONS
Теоретичні аспекти проблеми готовності педагогів до формування у старшокласниць усвідомленого материнства
Authors: Багінська Алевтина
Published: July 2024

У статті визначено критерії і показники, схарактеризовано орієнтовні рівні готовності педагогів до формування у дівчат-старшокласниць усвідомленого материнства.
Digital media as a tool for developing foreign language communicative competence in the field of higher education
Authors: Kapysheva Gulnar , Ismailova Gainigul , Kozhakhmetova Dinara
Published: July 2024

This article examines the role of digital media in the development of students ' foreign language communicative competence in higher education. The research is based on the analysis of modern technologies and techniques used for teaching foreign languages, as well as on the practical experience of teachers and students.
Обов’язки доказування у нотаріальному провадженні
Authors: Баранкова Вікторія
Published: July 2024

Статтю присвячено дослідженню особливостей обов’язків доказування у нотаріальному процесі. Виходячи з особливостей процесу доказування, що зумовлюються предметом нотаріальної діяльності, який становлять безспірні документи, права та факти і, як наслідок, відсутністю спору про право чи про факт, а також засад змагальності у нотаріальному процесі, обґрунтовується існування властивих саме нотаріальному процесу правил доказування, зокрема, й формування обов’язків доказування у суб’єктів нотаріальних процесуальних правовідносин стосовно різних елементів процесу доказування, серед яких виділено вказівку на факти, визначення доказів, подання (витребування) доказів, дослідження доказів, оцінку доказів. Висновується, що термін «обов’язки доказування» не збігається за змістом із терміном «обов’язки щодо подання доказів». Доводиться, що носіями обов’язків доказування у нотаріальному процесі є нотаріус (нотаріальний орган) та заінтересовані особи - учасники вчинюваної нотаріальної дії; кожен елемент процесу доказування характеризується різним суб’єктним складом і різними за змістом діями учасників нотаріальної дії, якими реалізуються належні їм процесуальні права та обов’язки; нотаріус є суб’єктом доказування стосовно практично всіх елементів процесу доказування, за винятком подання доказів; невиконання обов’язків доказування тягне за собою своєрідні правові санкції, що є різними для нотаріуса та для заінтересованих учасників нотаріальної дії. Визначаються наслідки невиконання обов’язків доказування у нотаріальній справі, що є різними для нотаріуса та заінтересованих осіб.
Диспластичні зміни тканини молочних залоз у хворих з обтяжливим онкологічним анамнезом
Authors: Кебало Дмитро , Званцева Еліна , Погоріла Тетяна
Published: July 2024

Зміни в тканинах молочної залози у жінок з обтяжливим онкологічним анамнезом по прямій лінії з появою атипових змін в клітинах вогнищ підлягають хірургічному лікуванню з гістологічною експрес діагностикою.
Деякі аспекти сучасного фотокаталізу
Authors: Козьма Антон
Published: July 2024

Фотокаталіз є одним із найбільш перспективних напрямків сучасного каталізу. На поверхні твердих переважно неорганічних зразків під дією сонячного випромінювання органічні речовини зазнають каталітичних перетворень. Поверхня комерційного фотокаталізатора титан диоксиду TiO2, опромінена ультрафіолетовим світлом, здатна повністю окиснювати більшість органічних сполук. Такий ефект успішно використовується при очищенні води та повітря, в самоочисних стеклах і дзеркалах. Огляд низки новітніх публікацій показав, що високу фотокаталітичну активність також демонструють численні оксидні, халькогенідні, нітридні, карбонвмісні та складні композитні зразки. За їх допомогою у природних водоймах можна дезактивувати антибіотики амоксицилін та тетрациклін, вони сприяють деградації забруднюючих барвників, дозволяють розщеплювати воду та інші гідроген-оксигенвмісні речовини й генерувати «зелений» водень ‒ різновид екологічно безпечного пального, можуть використовуватись для перетворення тривіальних речовин (вуглекислого газу, водяної пари, лігніну) на цінні продукти (спирти, альдегіди, органічні кислоти) тощо.
Methodology for conducting farmer training
Authors: Duneva Emiliya
Published: July 2024

The article attempts to design a methodology for training professional farmers in smart agriculture as an overview and digital tools. The set of the study is to outline and analyze the new techniques of agricultural process management. The findings of the study and research can help create a methodology for training farmers in the country and the country on digitization and smart agriculture.
Воднева енергетика в Україні: перспективи та її виклики
Authors: Боднарчук Анастасія
Published: July 2024

У статті розглядаються перспективи та виклики розвитку водневої енергетики в Україні у контексті заміщення російських енергоресурсів та підвищення енергетичної незалежності. Розкрито історію розвитку водневої енергетики у світі, її переваги та деякі технології виробництва водню. Аналізуються потенціал України для виробництва та експорту водню до Європейського Союзу, а також можливості переобладнання національної газотранспортної системи для транспортування водню. Окрема увага приділяється ролі наукових досліджень й освіти у підготовці кваліфікованих фахівців цієї сфери. Висновується, що воднева енергетика може стати важливим чинником енергетичної безпеки та економічного зростання України.